bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pleural plaques and risk of lung cancer in workers formerly occupationally exposed to asbestos: extension of follow-up
Authors: Gallet Justine , Laurent François , Paris Christophe , Clin Bénédicte , Gislard Antoine , Thaon Isabelle , Chammings Soizick , Gramond Celine , Ogier Guy , Ferretti Gilbert , Andujar Pascal , Brochard Patrick , Delva Fleur , Pairon Jean-Claude , Lacourt Aude 
Published: August 2022

BackgroundOccupational asbestos exposure is associated with pleural plaques (PP), a benign disease often seen as a marker of past exposure to asbestos and lung cancer. The association between these two diseases has not been formally proved, the aim of this study was to evaluate this association in the asbestos-related disease cohort (ARDCO) cohort.MethodsARDCO is a French multicentric cohort including workers formerly occupationally exposed to asbestos from 2003 to 2005. CT scan was performed to diagnose PP with double reading and lung cancer (incidence and mortality) was followed through health insurance data and death certificates. Cox models were used to estimate the association between PP and lung cancer adjusting for occupational asbestos exposure (represented by cumulative exposure index, time since first exposure and time since last exposure) and smoking status.ResultsA total of 176 cases (of 5050 subjects) and 88 deaths (of 4938 subjects) of lung cancer were recorded. Smoking status was identified as an effect modifier. Lung cancer incidence and mortality were significantly associated with PP only in non-smokers, respectively, HR=3.13 (95% CI 1.04 to 9.35) and HR=16.83 (95% CI 1.87 to 151.24) after adjustment for age, occupational asbestos exposure and smoking status.ConclusionsARDCO study was the first to study this association considering equal asbestos exposure, and more specifically, our study is the first to test smoking as an effect modifier, so comparison with scientific literature is difficult. Our results seem to consolidate the hypothesis that PP may be an independent risk factor for lung cancer but they must be interpreted with caution.
Unveiling hidden physics at the LHC
Authors: Fischer Oliver , Mellado Bruce , Antusch Stefan , Bagnaschi Emanuele , Banerjee Shankha , Beck Geoff , Belfatto Benedetta , Bellis Matthew , Berezhiani Zurab , Blanke Monika , Capdevila Bernat , Cheung Kingman , Crivellin Andreas , Desai Nishita , Dev Bhupal , Godbole Rohini , Han Tao , Harris Philip , Hoferichter Martin , Kirk Matthew , Kulkarni Suchita , Lange Clemens , Lassila-Perini Kati , Liu Zhen , Mahmoudi Farvah , Manzari Claudio Andrea , Marzocca David , Mukhopadhyaya Biswarup , Pich Antonio , Ruan Xifeng , Schnell Luc , Thaler Jesse , Westhoff Susanne 
Published: August 2022

AbstractThe field of particle physics is at the crossroads. The discovery of a Higgs-like boson completed the Standard Model (SM), but the lacking observation of convincing resonances Beyond the SM (BSM) offers no guidance for the future of particle physics. On the other hand, the motivation for New Physics has not diminished and is, in fact, reinforced by several striking anomalous results in many experiments. Here we summarise the status of the most significant anomalies, including the most recent results for the flavour anomalies, the multi-lepton anomalies at the LHC, the Higgs-like excess at around 96 GeV, and anomalies in neutrino physics, astrophysics, cosmology, and cosmic rays. While the LHC promises up to 4 $$\hbox {ab}^{-1}$$

ab

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of integrated luminosity and far-reaching physics programmes to unveil BSM physics, we consider the possibility that the latter could be tested with present data, but that systemic shortcomings of the experiments and their search strategies may preclude their discovery for several reasons, including: final states consisting in soft particles only, associated production processes, QCD-like final states, close-by SM resonances, and SUSY scenarios where no missing energy is produced. New search strategies could help to unveil the hidden BSM signatures, devised by making use of the CERN open data as a new testing ground. We discuss the CERN open data with its policies, challenges, and potential usefulness for the community. We showcase the example of the CMS collaboration, which is the only collaboration regularly releasing some of its data. We find it important to stress that individuals using public data for their own research does not imply competition with experimental efforts, but rather provides unique opportunities to give guidance for further BSM searches by the collaborations. Wide access to open data is paramount to fully exploit the LHCs potential.
Palaeomagnetic evidence for the age of the Stornoway Formation
Authors: Storetvedt K. M. , Steel R. J. 
Published: August 2022

Synopsis
A palaeomagnetic study of material from the lowermost and most fine-grained layers of the Stornoway sediments suggests a late Permian-Triassic age for this formation. This supports recent suggestions that the Stornoway Formation may be an onshore representative of the many deep Mesozoic basins recently discovered in surrounding coastal waters.
IL6 and CCL18 Mediate Cross-talk between VHL-Deficient Kidney Cells and Macrophages during Development of Renal Cell Carcinoma
Authors: Nguyen Thi-Ngoc , Nguyen-Tran Hieu-Huy , Chen Chen-Yun , Hsu Tien 
Published: August 2022

Abstract

Loss of the von Hippel–Lindau (VHL) tumor suppressor gene function accounts for 70% to 80% of all clear-cell renal cell carcinoma (ccRCC) cases, the most prevalent form of RCC. Accumulating evidence has indicated that ccRCC arises from sites of chronic inflammation, yet how ccRCC tumor cells interact with immune components of the microenvironment has not been fully elucidated. In this study, we used unbiased proteomic and genomic analyses on components of the tumor microenvironment under different conditions, identifying the molecular and cellular mechanisms that underlie the cross-talk between VHL-deficient kidney tubule cells and macrophages. In vitro and in a Vhlh conditional knockout mouse model, VHL-deficient noncancerous kidney epithelial cells, representing the early stage of ccRCC initiation, secreted IL6 that induced macrophage infiltration and polarization toward the protumorigenic M2 phenotype. Activated human macrophages secreted CCL18 and TGFβ1 to stimulate epithelial-to-mesenchymal transition (EMT) of the kidney tubule cells. Treatment with IL6-neutralizing antibody rescued inflammatory, proliferative, and EMT phenotypes of kidney epithelial cells in Vhlh conditional knockout mice. Furthermore, in a human ccRCC xenograft model, exogenous human primary or cultured macrophages significantly promoted primary tumor growth and metastasis in a CCL18-dependent manner. These findings identify specific factors involved in reciprocal cross-talk between tumor cells and immune components in the microenvironment, thus providing an avenue for early intervention in ccRCC.

Significance:
The identification of VHL-deficient kidney tubule cell cross-talk with macrophages regulated by IL6 and CCL18 reveals potential targets for the prevention and treatment of ccRCC.
Investigating Morphologic Correlates of Driver Gene Mutation Heterogeneity via Deep Learning
Authors: Song Andrew H. , Williamson Drew F.K. , Mahmood Faisal 
Published: August 2022

AbstractDespite the crucial role of phenotypic and genetic intratumoral heterogeneity in understanding and predicting clinical outcomes for patients with cancer, computational pathology studies have yet to make substantial steps in this area. The major limiting factor has been the bulk gene–sequencing practice that results in loss of spatial information of gene status, making the study of intratumoral heterogeneity difficult. In this issue of Cancer Research, Acosta and colleagues used deep learning to study if localized gene mutation status can be predicted from localized tumor morphology for clear cell renal cell carcinoma. The algorithm was developed using curated sets of matched hematoxylin and eosin and IHC images, which represent spatially resolved morphology and genotype, respectively. This study confirms the existence of a strong link between morphology and underlying genetics on a regional level, paving the way for further investigations into intratumoral heterogeneity.See related article by Acosta et al., p. 2792
A Druggable Rheostat for Ewing Sarcoma?
Authors: Weiss Kurt R. , Bailey Kelly M. 
Published: August 2022

SummaryThe posterior HOXD enhancer is an EWSR1::FLI1-dependent regulator of HOXD13 expression in Ewing sarcoma. HOXD13 expression promotes a mesenchymal cell state. Through antagonistic transcriptional programs, EWSR1::FLI1 and HOXD13 serve as master regulators of Ewing cell plasticity. Targeting Ewing cells as they exist in/transition between mesenchymal states is a priority.See related article by Apfelbaum et al., p. 4466
Negócio jurídico das regras processuais e a Fazenda Pública
Authors: Soares Daniela Costa , Altoé Maria Izabel Pereira de Azevedo 
Published: August 2022

O Novo Código Processual Civil de 2015 passou a prever, no seu artigo 190 “uma cláusula geral negocial” que permite que as partes adequem o procedimento à luz do caso concreto naqueles processos que admitem autocomposição. A limitação da clausula geral negocial aos processos que admitam autocomposição gerou o entendimento inicial de que seria vedada a sua realização pela Fazenda Pública em Juízo. O presente artigo pretende avaliar a possibilidade de realização de transação processual por entes públicos e as limitações aplicáveis em face das regras fundamentais do processo nos negócios jurídicos em geral, bem como a possibilidade de realização do mencionado instituto nas lides dos entes públicos e as restrições impostas pelo regime jurídico diferenciado da administração pública, da indisponibilidade do interesse público e das prerrogativas processuais da Fazenda Pública.
Redescriptions of the type specimens of synonymous nominal taxa of sea snakes (Serpentes: Elapidae: Hydrophis, Laticauda) at the Zoological Survey of India
Authors: MONDAL SONIA , GANESH S.R. , SETHY P.G.S. , RAGHUNATHAN C. , RAHA SUJOY , SARKAR SAGNIK 
Published: July 2022

We redescribe and illustrate the type specimens of ten taxa of sea snakes of the genera Hydrophis Latreille in Sonnini & Latreille, 1801 and Laticauda Laurenti, 1768 in the collections of the Zoological Survey of India. The specimens comprise holotypes and syntypes of ten synonymous nominal taxa that represent seven valid nominal taxa. We here clarify that one specimen ZSI 8278 is a syntype of Hydrophis dayanus Stoliczka, 1872, not holotype as previously stated. In one case, four holotypes of four nominal taxa are synonyms of the same taxon—Hydrophis cyanocinctus Daudin, 1803. Many of these type specimens are herein first depicted in photographs in a publication.
„Oby mój język potrafił opiewać Twoje słowa” (Ps 119 [118],172) – z badań nad leksykalną wariantywnością psałterzowych redakcji cerkiewnosłowiańskich. O przekładzie gr. συνάγω, ἐπισυνάγω i συλλέγω
Authors: Szulc Arleta 
Published: August 2022

“Let my tongue make songs in praise of Your word” (Ps 119 [118]:172) – From the Research on the Lexical Variety of Church Slavonic Psalter Redactions: On Translation of the Greek συνάγω, ἐπισυνάγω and συλλέγω This article is another report from the ongoing comparative lexical analyses of manuscripts representing separate Church Slavonic Psalter redactions. It is focused on quantitative and qualitative characterisation of the (Old) Church Slavonic equivalents of the Greek verbs συνάγω, ἐπισυνάγω and συλλέγω which occur in the Psalters under comparison. The study offers an interpretation of the observed similarities and differences among the Psalters regarding the choice of vocabulary in focus. It also considers the Hebrew verbs corresponding to the analysed (O)CS and Greek equivalents. Observations made in the article include illustrative examples. „Oby mój język potrafił opiewać Twoje słowa” (Ps 119 [118], 172) – z badań nad leksykalną wariantywnością psałterzowych redakcji cerkiewnosłowiańskich. O przekładzie gr. συνάγω, ἐπισυνάγω i συλλέγω Artykuł jest kolejną relacją z sukcesywnie prowadzonych analiz porównawczych słownictwa zawartego w rękopisach reprezentujących poszczególne cerkiewnosłowiańskie redakcje psałterzowe. Koncentruje się na ilościowej i jakościowej charakterystyce (s)cs. ekwiwalentów greckich czasowników συνάγω, ἐπισυνάγω i συλλέγω obecnych w porównywanych psałterzach. Podaje interpretację zaobserwowanych podobieństw i różnic między nimi w doborze rozpatrywanego słownictwa. Uwagę zwraca również na hebrajskie odpowiedniki analizowanych ekwiwalentów (staro-)cerkiewnosłowiańsko-greckich. Komentarze artykułu dopełnia odpowiedni materiał ilustracyjny.
Spatiotemporal Reconstruction of Antarctic Near-Surface Air Temperature from MODIS Observations
Authors: Zhang Xueying , Dong Xu , Zeng Jing , Hou Shugui , Smeets Paul C. J. P. , Reijmer Carleen H. , Wang Yetang 
Published: August 2022

Abstract
MODIS (Moderate Resolution Imaging Spectroradiometer) land surface temperature measurements in combination with in situ air temperature records from 119 meteorological stations are used to reconstruct a monthly near-surface air temperature product over the Antarctic Ice Sheet (AIS) by means of a neural network model. The product is generated on a regular grid of 0.05° × 0.05°, spanning from 2001 to 2018. Comparison with independent in situ air temperature measurements shows low uncertainty, with a mean bias of 0.09°C, a mean absolute error of 2.23°C, and a correlation coefficient of 97%. Furthermore, the performance of the reconstruction is better than ERA5 (the fifth-generation ECMWF reanalysis model) against in situ measurements. For the 2001–18 period, the MODIS-based near-surface air temperature product yields annual warming in the East Antarctica, but cooling in the Antarctic Peninsula and West Antarctica. However, they are not statistically significant. This product can also be used to investigate the impact of the Southern Hemisphere annual mode (SAM) on year-to-year variability of air temperature. The enhanced positive phase of SAM in recent decades in austral summer has a cooling effect on East and West Antarctica. In addition, the dataset has the potential application for climate model validation and data assimilation due to the independence of the input of a numerical weather prediction model.
Seasonal Propagation Characteristics from Meteorological to Hydrological Drought and Their Dynamics in the Headstreams of the Tarim River Basin
Authors: Wang Zhixia , Huang Shengzhi , Huang Qiang , Duan Weili , Leng Guoyong , Guo Yi , Zheng Xudong , Nie Mingqiu , Han Zhiming , Dong Haixia , Peng Jian 
Published: August 2022

Abstract
In the propagation from meteorological to hydrological drought, there are time-lag and step-abrupt effects, quantified in terms of propagation time and threshold, which play an important role in hydrological drought early warning. However, seasonal drought propagation time and threshold and their dynamics as well as the corresponding driving mechanism remain unknown in a changing environment. To this end, the standardized precipitation index (SPI) and standardized runoff index (SRI) were used respectively to characterize meteorological and hydrological droughts and to determine the optimal propagation time. Then, a seasonal drought propagation framework based on Bayesian network was proposed for calculating the drought propagation threshold with SPI. Finally, the seasonal dynamics and preliminary attribution of propagation characteristics were investigated based on the random forest model and correlation analysis. The results show that 1) relatively short propagation time (less than 9 months) and large propagation threshold (from −3.18 to −1.19) can be observed in the Toxkan River basins (subbasin II), especially for spring, showing low drought resistance; 2) drought propagation time shows an extended trend in most seasons, while the drought propagation threshold displays an increasing trend in autumn and winter in the Aksu River basin (subbasins I–II), and the opposite characteristics in the Hotan and Yarkant River basins (subbasins III–V); and 3) the impacts of precipitation, temperature, potential evapotranspiration, and soil moisture on drought propagation dynamics are inconsistent across subbasins and seasons, noting that reservoirs serve as a buffer to regulate the propagation from meteorological to hydrological droughts. The findings of this study can provide scientific guidelines for watershed hydrological drought early warning and risk management.

Significance Statement
The aim of this study is to better understand how the delayed and step-abrupt effects of propagation from meteorological drought to hydrological drought can be characterized through propagation time and threshold. These response indicators determine the resistance of a catchment to hydrological droughts and meteorological droughts. They can help water resources management agencies to mitigate hydrological droughts by taking measures such as water storage, increasing revenue, and reducing expenditure. The findings of this study can provide scientific guidelines for watershed hydrological drought early warning and risk management.
The Origin and Fate of Antarctic Intermediate Water in the Southern Ocean
Authors: Li Zhi , Groeskamp Sjoerd , Cerovečki Ivana , England Matthew H. 
Published: August 2022

Abstract
Using observationally based hydrographic and eddy diffusivity datasets, a volume budget analysis is performed to identify the main mechanisms governing the spatial and seasonal variability of Antarctic Intermediate Water (AAIW) within the density range γn = (27.25–27.7) kg m−3 in the Southern Ocean. The subduction rates and water mass transformation rates by mesoscale and small-scale turbulent mixing are estimated. First, Ekman pumping upwells the dense variety of AAIW into the mixed layer south of the Polar Front, which can be advected northward by Ekman transport into the subduction regions of lighter-variety AAIW and Subantarctic Mode Water (SAMW). The subduction of light AAIW occurs mainly by lateral advection in the southeast Pacific and Drake Passage as well as eddy-induced flow between the Subantarctic and Polar Fronts. The circumpolar-integrated total subduction yields from −5 to 19 Sv (1 Sv ≡ 106 m3 s−1) of AAIW volume loss. Second, the diapycnal transport from subducted SAMW into the AAIW layer is predominantly by mesoscale mixing (2–13 Sv) near the Subantarctic Front and vertical mixing in the South Pacific, while AAIW is further replenished by transformation from Upper Circumpolar Deep Water by vertical mixing (1–10 Sv). Last, 3–14 Sv of AAIW are exported out of the Southern Ocean. Our results suggest that the distribution of AAIW is set by its formation due to subduction and mixing, and its circulation eastward along the ACC and northward into the subtropical gyres. The volume budget analysis reveals strong seasonal variability in the rate of subduction, vertical mixing, and volume transport driving volume change within the AAIW layer. The nonzero volume budget residual suggests that more observations are needed to better constrain the estimate of geostrophic flow and mesoscale and small-scale mixing diffusivities.
Analytical and Residual Bootstrap Methods for Parameter Uncertainty Assessment in Tidal Analysis with Temporally Correlated Noise
Authors: Innocenti Silvia , Matte Pascal , Fortin Vincent , Bernier Natacha 
Published: August 2022

Abstract
Reconstructing tidal signals is indispensable for verifying altimetry products, forecasting water levels, and evaluating long-term trends. Uncertainties in the estimated tidal parameters must be carefully assessed to adequately select the relevant tidal constituents and evaluate the accuracy of the reconstructed water levels. Customary harmonic analysis uses ordinary least squares (OLS) regressions for their simplicity. However, the OLS may lead to incorrect estimations of the regression coefficient uncertainty due to the neglect of the residual autocorrelation. This study introduces two residual resamplings (moving-block and semiparametric bootstraps) for estimating the variability of tidal regression parameters and shows that they are powerful methods to assess the effects of regression errors with nontrivial autocorrelation structures. A Monte Carlo experiment compares their performance to four analytical procedures selected from those provided by the RT_Tide, UTide, and NS_Tide packages and the robustfit.m MATLAB function. In the Monte Carlo experiment, an iteratively reweighted least squares (IRLS) regression is used to estimate the tidal parameters for hourly simulations of one-dimensional water levels. Generally, robustfit.m and the considered RT_Tide method overestimate the tidal amplitude variability, while the selected UTide and NS_Tide approaches underestimate it. After some substantial methodological corrections the selected NS_Tide method shows adequate performance. As a result, estimating the regression variance–covariance with the considered RT_Tide, UTide, and NS_Tide methods may lead to the erroneous selection of constituents and underestimation of water level uncertainty, compromising the validity of their results in some applications.

Significance Statement
At many locations, the production of reliable water level predictions for marine navigation, emergency response, and adaptation to extreme weather relies on the precise modeling of tides. However, the complicated interaction between tides, weather, and other climatological processes may generate large uncertainties in tidal predictions. In this study, we investigate how different statistical methods may lead to different quantification of tidal model uncertainty when using data with completely known properties (e.g., knowing the tidal signal, as well as the amount and structure of noise). The main finding is that most commonly used statistical methods may estimate incorrectly the uncertainty in tidal parameters and predictions. This inconsistency is due to some specific simplifying assumptions underlying the analysis and may be reduced using statistical techniques based on data resampling.
Prognostic Impact of Lymphocyte-to-C-Reactive Protein Ratio in Patients Who Underwent Surgical Resection for Pancreatic Cancer
Authors: Iseda Norifumi , Iguchi Tomohiro , Hirose Kosuke , Itoh Shinji , Honboh Takuya , Sadanaga Noriaki , Matsuura Hiroshi 
Published: August 2022

Background Increasing evidence indicates that increased systemic inflammation is correlated with poorer cancer-specific survival in various cancer types. This study aimed to evaluate the prognostic value of various combinations of inflammatory factors in patients who underwent surgical resection for pancreatic cancer (PC). Methods We retrospectively analyzed 97 consecutive patients with PC who underwent pancreatectomy. We assessed the predictive impact for recurrence using a combination of 5 inflammatory markers and focused on the lymphocyte-C-reactive protein ratio (LCR) to elucidate its prognostic and predictive value for recurrence-free survival (RFS) and overall survival (OS) in univariate and multivariate analyses using the Cox proportional hazards model. Results Low preoperative LCR was correlated with low serum hemoglobin, low serum albumin concentration, high frequency of microscopic vascular invasion, and high frequency of microscopic perineural invasion. The low LCR group had significantly worse RFS and OS. Lower preoperative LCR was an independent predictor of shorter RFS and OS in this cohort. Discussion Preoperative LCR is a novel and convenient prognostic marker for patients with PC. Patients with low LCR may require more favorable intensive therapy.