bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of sleep duration with neurocognitive development in the first 2 years of life
Authors: Cao Shuting , Liu Juan , Li Yuanyuan , Xu Shunqing , Xia Wei 
Published: January 2022

SummaryThe effect of sleep duration on neurocognitive development in infants and toddlers remains unclear. We aimed to investigate the relationship between sleep duration and neurocognitive development in infancy. Based on a prospective birth cohort, 2220 mother–infant pairs were enrolled in Wuhan, China, between January 2014 and October 2017. Sleep duration was evaluated at 1, 6, 12 and 24 months via parent‐report questionnaires. To assess the children’s neurocognitive development at 2 years old, the Bayley Scales of Infant Development of China Revision was used to assess the Mental Development Index (MDI) and Psychomotor Development Index (PDI). A group‐based semiparametric mixture model was used to estimate the developmental trajectories of the total, nighttime and daytime sleep duration. The associations of sleep duration at each age and sleep duration trajectories with Mental Development Index scores and Psychomotor Development Index scores were analysed using generalized linear models. Daytime sleep duration (≥ 10.0 hr) at 1 month was associated with lower Mental Development Index scores (β = −3.55, 95% confidence interval: −6.02, −1.08) and lower Psychomotor Development Index scores (β = −2.87, 95% confidence interval: −4.94, −0.81). Nighttime sleep duration (≤ 7.0 hr) at 6 months was associated with lower Mental Development Index scores (β = −7.02, 95% confidence interval: −11.02, −3.01). Daytime sleep duration (> 4 hr) and nighttime sleep duration (< 8 hr) at 12 months were associated with lower Mental Development Index scores (β = −9.17, 95% confidence interval: −15.35, −2.98) and lower Psychomotor Development Index scores (β = −8.14, 95% confidence interval: −13.56, −2.71), respectively. In further sleep duration trajectories analyses, lower Mental Development Index scores were significantly associated with the “decreased and then increased nighttime sleepers” trajectory (β = −4.39, 95% confidence interval: −8.02, −0.76), and “long and decreased daytime sleepers” trajectory (β = −2.44, 95% confidence interval: −4.58, −0.30). These results showed that short nighttime sleep duration and long daytime sleep duration in infancy were detrimental to children’s neurocognitive development.
Molecular ecology of a shallow water shrimp, Acetes sibogae sibogae Hansen 1919: Evidence for strongly limited gene flow across the western Pacific
Authors: Hardianto Eko , Fukuchi Jun , Hanamura Yukio , Wijayanti Diah Permata , Sabdono Agus , Imai Hideyuki 
Published: January 2022

AbstractThe shallow water shrimp Acetes sibogae sibogae is an ecological and economically important organism in the Asian region. We assessed the genetic diversity and population structure of this species based on samples obtained from eight sites in Japan, the Philippines and Indonesia. Nucleotide sequence analyses were performed based on PCR‐amplified mitochondrial DNA fragments comprising the control region and part of the 12S rRNA gene. In total, 656 bp nucleotide sequences were obtained from 377 individuals. The results show a low haplotype diversity value in shrimp from the Kokuba‐gawa River (0.5) in Japan and intermediate values (0.79–0.99) in other populations. While nucleotide diversity estimates in all sampled localities were lower (0.17%–0.86%) than those reported in other crustaceans, analysis of molecular variance revealed significant genetic differentiation (p < .001) among all sites. Furthermore, the mean fixation index estimate was very high (FST: 0.27), indicating that dispersal potential among sites was low and gene flow, therefore, was restricted. The mismatch distribution of pairwise differences between haplotypes indicated that A. s. sibogae did not fit a sudden population expansion model. Overall, the present study indicates that wild stocks of A. s. sibogae on Okinawa‐jima Island and the Philippine and Indonesian Archipelagos should be assigned high importance for conservation management of this species because adapted genotypes have significant evolutionary potential during environmental changes.[Correction added on 5th February 2022, after first online publication: Values have been corrected in the Abstract section.]
Microbiomes associated with cultures of Gambierdiscus australes and Ostreopsis cf. ovata, two epibenthic dinoflagellates from the NE Atlantic Ocean (Las Palmas, Gran Canaria)
Authors: Denaro Renata , Crisafi Francesca , Smedile Francesco , Soprano Vittorio , Rossi Rachele , Zingone Adriana , Acosta Felix , Giacobbe Maria Grazia 
Published: January 2022

AbstractOur study focuses on bacterial communities associated with two benthic, epiphytic dinoflagellates, Gambierdiscus australes and Ostreopsis cf. ovata, isolated from coastal waters of Las Palmas, Gran Canaria, and grown in clonal cultures. The goal was to characterize the stable bacterial consortia found within the phycosphere of each dinoflagellate species and establish into which functional group they fell. High‐throughput sequencing (HTS) results highlighted a higher bacterial diversity in O. ovata compared with G. australes. Alphaproteobacteria dominated in both dinoflagellates with Marivita and Labrenzia as the most represented OTUs in Ostreopsis and Gambierdiscus, respectively, and Thalassospira and Oceanicaulis well represented in both species. Based on SIMPER analyses, Labrenzia and the Phycispherales SM1A02, dominant in Gambierdiscus and Ostreopsis, respectively, accounted for the most significant difference between the two microbiomes. The microbiomes described here differed from those described for the same dinoflagellate species in other studies, which could depend on differences in environmental conditions, macroalgal substrate, and/or growth stage or bloom phase of the microalgal hosts. The distinct bacterial communities associated with the two potentially toxic dinoflagellates, isolated from the same site and sampling event and cultivated under the same conditions, suggest different modalities of interaction and interexchange between bacteria and their hosts.
Gene drives for vertebrate pest control: Realistic spatial modelling of eradication probabilities and times for island mouse populations
Authors: Birand Aysegul , Cassey Phillip , Ross Joshua V. , Russell James C. , Thomas Paul , Prowse Thomas A. A. 
Published: January 2022

AbstractInvasive alien species continue to threaten global biodiversity. CRISPR‐based gene drives, which can theoretically spread through populations despite imparting a fitness cost, could be used to suppress or eradicate pest populations. We develop an individual‐based, spatially explicit, stochastic model to simulate the ability of CRISPR‐based homing and X chromosome shredding drives to eradicate populations of invasive house mice (Mus muculus) from islands. Using the model, we explore the interactive effect of the efficiency of the drive constructs and the spatial ecology of the target population on the outcome of a gene‐drive release. We also consider the impact of polyandrous mating and sperm competition, which could compromise the efficacy of some gene‐drive strategies. Our results show that both drive strategies could be used to eradicate large populations of mice. Whereas parameters related to drive efficiency and demography strongly influence drive performance, we find that sperm competition following polyandrous mating is unlikely to impact the outcome of an eradication effort substantially. Assumptions regarding the spatial ecology of mice influenced the probability of and time required for eradication, with short‐range dispersal capacities and limited mate‐search areas producing ‘chase’ dynamics across the island characterized by cycles of local extinction and recolonization by mice. We also show that highly efficient drives are not always optimal, when dispersal and mate‐search capabilities are low. Rapid local population suppression around the introduction sites can cause loss of the gene drive before it can spread to the entire island. We conclude that, although the design of efficient gene drives is undoubtedly critical, accurate data on the spatial ecology of target species are critical for predicting the result of a gene‐drive release.
SxsA, a novel surface protein mediating cell aggregation and adhesive biofilm formation of Staphylococcus xylosus
Authors: Schiffer Carolin J. , Schaudinn Christoph , Ehrmann Matthias A. , Vogel Rudi F. 
Published: January 2022

AbstractBiofilm formation of staphylococci has been an emerging field of research for many years. However, the underlying molecular mechanisms are still not fully understood and vary widely between species and strains. The aim of this study was to identify new effectors impacting biofilm formation of two Staphylococcus xylosus strains. We identified a novel surface protein conferring cell aggregation, adherence to abiotic surfaces, and biofilm formation. The S. xylosus surface protein A (SxsA) is a large protein occurring in variable sizes. It lacks sequence similarity to other staphylococcal surface proteins but shows similar structural domain organization and functional features. Upon deletion of sxsA, adherence of S. xylosus strain TMW 2.1523 to abiotic surfaces was completely abolished and significantly reduced in TMW 2.1023. Macro‐ and microscopic aggregation assays further showed that TMW 2.1523 sxsA mutants exhibit reduced cell aggregation compared with the wildtype. Comparative genomic analysis revealed that sxsA is part of the core genome of S. xylosus, Staphylococcus paraxylosus, and Staphylococcus nepalensis and additionally encoded in a small group of Staphylococcus cohnii and Staphylococcus saprophyticus strains. This study provides insights into protein‐mediated biofilm formation of S. xylosus and identifies a new cell wall‐associated protein influencing cell aggregation and biofilm formation.
TAPPing into the potential of inducible tau/APP transgenic mice
Authors: Xu Guilian , Ulm Brittany S. , Howard John , Fromholt Susan E. , Lu Qing , Lee Brian Benedict , Walker Ariel , Borchelt David R. , Lewis Jada 
Published: January 2022

AbstractAimsOur understanding of the pathological interactions between amyloidosis and tauopathy in Alzheimer's disease is incomplete. We sought to determine if the relative timing of the amyloidosis and tauopathy is critical for amyloid‐enhanced tauopathy.MethodsWe crossed an inducible tauopathy model with two β‐amyloid models utilising the doxycycline‐repressible transgenic system to modulate timing and duration of human tau expression in the context of amyloidosis and then assessed tauopathy, amyloidosis and gliosis.ResultsWe combined inducible rTg4510 tau with APPswe/PS1dE9 [Line 85 (L85)] mice to examine the interactions between Aβ and tauopathy at different stages of amyloidosis. When we initially suppressed mutant human tau expression for 14–15 months and subsequently induced tau expression for 6 months, severe amyloidosis with robust tauopathy resulted in rTg4510/L85 but not rTg4510 mice. When we suppressed mutant tau for 7 months before inducing expression for a subsequent 6 months in another cohort of rTg4510/L85 and rTg4510 mice, only rTg4510/L85 mice displayed robust tauopathy. Lastly, we crossed rTg4510 mice to tet‐regulated APPswe/ind [Line 107 (L107)] mice, using doxycycline to initially suppress both transgenes for 1 month before inducing expression for 5 months to model early amyloidosis. In contrast to rTg4510, rTg4510/L107 mice rapidly developed amyloidosis, accompanied by robust tauopathy.ConclusionsThese data suggest that tau misfolding is exacerbated by both newly forming Aβ deposits in younger brain and mature deposits in older brains. Refined use and repurposing of these models provide new tools to explore the intersection of ageing, amyloid and tauopathy and to test interventions to disrupt the amyloid cascade.
How effective and how expensive are interventions to reduce sedentary behavior? An umbrella review and meta‐analysis
Authors: Lam Kevin , Baurecht Hansjörg , Pahmeier Kathrin , Niemann Anja , Romberg Carolin , Biermann‐Stallwitz Janine , Neusser Silke , Wasem Jürgen , Mugler Nida , Welker Christine , Leitzmann Michael , Jochem Carmen 
Published: January 2022

SummaryA reduction in sedentary behavior (SB) can contribute to the prevention of chronic diseases. This is the first umbrella review that summarizes the effectiveness and monetary costs of different types of interventions to reduce SB across all age groups and populations in different settings. We comprehensively searched seven databases for systematic reviews and meta‐analyses and conducted an umbrella review of the effects of interventions to reduce SB. Additionally, we performed a meta‐analysis of primary studies included in the umbrella review. Furthermore, we analyzed health economic aspects of interventions to reduce SB. We included 40 systematic reviews in our umbrella review, with 136 primary studies suitable for further meta‐analyses. We found that interventions targeting the physical environment reduce SB most effectively in the majority of populations and settings. Workplace interventions reduced SB by −89.83 min/day (95% CI −124.58 to −55.09; p ≤ 0.0001). Twenty‐two of 169 primary studies (13.0%) contained health economic information. The intervention costs per participant ranged from €0 to €3587. Our findings demonstrate that physical environment interventions most effectively reduce SB in a majority of populations and settings. Health economic information was reported in few studies and was mostly restricted to acquisition costs.
Photoprotection by clothing: A review
Authors: Boothby‐Shoemaker Wyatt T. , Mohammad Tasneem F. , Ozog David M. , Lim Henry W. 
Published: January 2022

AbstractClothing is recognized by leading health agencies as a primary method to protect against the harmful effects of photodamage caused by ultraviolet (UV) radiation and visible light. The photoprotective capacity of clothing is commonly measured as the ultraviolet protective factor (UPF). While the technology driving photoprotective clothing has been well‐established, there continues to be efforts to discover new materials to improve the UPF of clothing. Here, we show increased Google searches for photoprotective clothing over the last decade, suggesting a high level of public interest in photoprotective clothing. In addition, we investigate the frequency of UPF‐graded photoprotective clothing sold by large retail stores featured inFortune1000. We review factors that alter the UPF of clothing and describe emerging textile technologies used to increase clothing's photoprotective capacity. Finally, we compare how photoprotective clothing is regulated among different countries, the importance of photoprotective clothing in occupational health, and research in visible light and clothing photoprotection.
Reframing the politics of natural resource governance in Africa: Insights from the local content legislation process in Ghana
Authors: Ayanoore Ishmael , Hickey Sam 
Published: January 2022

AbstractNew oil‐producing countries in Sub‐Saharan Africa have moved rapidly to adopt local content legislation to ensure that locally owned firms benefit from natural resource finds. Current research into this move frames local content development in Africa as existing on a continuum between elite projects to accumulate rents and build a domestic capitalist class. This article problematizes such accounts through an in‐depth case study of Ghana. By deploying an adapted “political settlements” framework that incorporates the role of ideas as well as transnational agency, we show that elite commitment to local content reforms is driven by the broader politics of regime survival and paradigmatic ideas rather than political economy factors alone.Related ArticlesAnuar, Amalina, and Aninda Dewayanti. 2021. “Trust in the Process: Renewable Energy Governance in Malaysia and Indonesia.” Politics & Policy 49(3): 740–70. https://doi.org/10.1111/polp.12409Khodr, Hiba, and Isabella Ruble. 2013. “Energy Policies and Domestic Politics in the MENA Region in the Aftermath of the Arab Upheavals: The Cases of Lebanon, Libya, and KSA.” Politics & Policy 41(5): 656–89. https://doi.org/10.1111/polp.12033Osman, Antwi‐Boateng, and Mamudu Abunga Akudugu. 2020. “Golden Migrants: The Rise and Impact of Illegal Chinese Small‐Scale Mining in Ghana.” Politics & Policy 48(1): 135–67. https://doi.org/10.1111/polp.12342
Value Creation in the Public Service Ecosystem: An Integrative Framework
Authors: Osborne Stephen P. , Powell Madeline , Cui Tie , Strokosch Kirsty 
Published: January 2022

AbstractThis article develops the concept of the “public service ecosystem” across four levels—the institutional, service, individual, and beliefs levels. It does this by integrating service management and marketing theory with public administration and management theory. Consequently, it explores both the dimensions of value and value creation within the public service ecosystem at each level, and the interactions and inter‐relationships across these levels. It concludes with the key implications for public administration and management theory and pactice.
End‐of‐life palliative home care for children with cancer: A qualitative study on parents’ experiences
Authors: Hansson Helena , Björk Maria , Santacroce Sheila Judge , Raunkiær Mette 
Published: January 2022

AbstractBackgroundThere is insufficient knowledge available about the impact of paediatric palliative care at home on meeting family needs and ensuring the highest quality of care for the dying child. The aim of this study was to elucidate parents’ experiences of how and why home‐based paediatric palliative care impacted the entire family during their child's final phase of life.MethodsThe study used a qualitative design. Semi‐structured interviews were conducted with the bereaved parents of children who had received palliative care at home from a paediatric cancer hospital department programme that was based on collaboration with community nurses and the paediatric palliative care service. The interviews were transcribed verbatim, and qualitative content analysis was applied. The Ecocultural theory was used to explain the findings.ResultsThree main themes emerged: (1) involvement enabling a sense of control and coping, (2) sustaining participation in everyday family life routines and (3) making room for presence and comfort during and after the end‐of‐life trajectory.ConclusionEnd‐of‐life palliative care at home can enable parents and other family members to maintain a sense of control, presence and semblance of everyday life. It contributes to managing and alleviating the burden and distress during the last phase of the child's life and during bereavement. We suggest that healthcare professionals support family members in participation and daily life routines and activities during a child's EOL care, as it affects the well‐being of the entire family.
Disease mechanisms in Sjögren’s syndrome: What do we know?
Authors: Jonsson Roland 
Published: January 2022

AbstractWhy should we explore and study disease mechanisms? This is particularly important when we are dealing with complex pathogenesis without a direct causal agent, for example, syndromes with multiple organ involvements. Sjögren's syndrome is definitely such an entity. Also, there are a number of reasons for such studies such as disclosing the aetiology, to identify biomarkers for diagnosis and assessment of the disease process and monitor response to treatment, to determine targets for treatment, to define critical items in classification criteria, amongst others. Samples available for the study of disease mechanisms in Sjögren's syndrome have included serum (autoantibodies, cytokines), DNA (gene profiling, GWAS), cells (phenotypes/flow cytometry, proportion of cells/CyTOF), tissue (focal inflammation, germinal centres, mass cytometry), and saliva (proteomics, biochemistry, mucosal immunity). An original explanatory concept for the pathogenesis of Sjögren's syndrome proposed a specific and self‐perpetuating immune‐mediated loss of exocrine tissue as the principal cause of glandular hypofunction. This hypothesis however falls short of accommodating several Sjögren's syndrome‐related phenomena and experimental findings. Today, the emergence of advanced bio‐analytical platforms has further enabled the identification of central pathogenic processes and potential biomarkers. The purpose of this minor review is to highlight a selection of previous but also recent and novel aspects on the disease mechanisms in Sjögren's syndrome.
Transgender‐based disparities in suicidality: A population‐based study of key predictions from four theoretical models
Authors: Bränström Richard , Stormbom Isabella , Bergendal Morgan , Pachankis John E. 
Published: January 2022

AbstractIntroductionNumerous studies have reported a high prevalence of suicidality among transgender individuals. Yet few studies have reported results from population‐based samples, leaving open questions about the generalizability of existing findings. Factors proposed to explain transgender individuals’ elevated risk of suicidality derive from several theoretical models (i.e., clinical model, interpersonal model, minority stress model, and societal integration model). These models identify both general risk factors (e.g., mental health risks and interpersonal risks) assumed to be elevated among transgender individuals because of transgender individuals’ exposure to stigma‐related disadvantage and the stigma‐specific risks themselves (e.g., minority stressors such as discrimination). This is one of the first population‐based studies to examine differences in suicidality between transgender and cisgender individuals and theoretically derived factors potentially explaining such differences.MethodsA sample of 533 transgender and 104,757 cisgender individuals (age 16–84) was analyzed.ResultsCompared to cisgender individuals, transgender individuals were at a substantially higher risk of reporting both lifetime and past 12‐month suicidality. Several factors partially mediated the increased risk of suicidality among transgender compared to cisgender individuals, including depressive symptoms, lack of social support, and exposure to discrimination.ConclusionsThis study suggests that transgender people experience multiple psychosocial health threats and calls for interventions to reduce these threats.
Trajectories of suicidal ideation following separation from military service: Overall trends and group differences
Authors: Hoffmire Claire A. , Borowski Shelby , Griffin Brandon J. , Maguen Shira , Vogt Dawne 
Published: January 2022

AbstractBackgroundAlthough the transition out of military service is a high‐risk time for suicidal ideation (SI), a paucity of research examines the development of SI during this transition process and veteran subgroups at risk for SI as they readjust to civilian life.MethodsA population‐based, longitudinal post‐9/11 veteran cohort reported SI frequency at 3, 9, 15, 21, and 27 months post‐separation using the Patient Health Questionnaire‐9. We identified distinct trajectories of SI over time (i.e., classes) using latent class growth analysis and examined demographic and military service predictors of class membership overall and by gender using multinomial logistic regression.ResultsFour SI trajectories that were similar across genders were identified: resilient (90.1%), delayed onset (5.0%), remitting (2.7%), and chronic (2.2%). Younger age, minority race/ethnicity, medical and other (vs. honorable) separation types, and Veterans Health Administration service utilization were associated with increased odds of assignment to a higher‐risk trajectory (delayed onset, remitting, and/or chronic vs. resilient), whereas continued service in the National Guard/Reserves and officer rank was associated with lower odds of assignment to a higher‐risk trajectory.ConclusionsFindings regarding veterans at greatest risk for SI following military separation can inform targeted assessment and early intervention efforts.