bluuebunny/crossref_metadata_2025_split huggingface dataset:
N/C Interactions Are Dispensable for Normal In Vivo Functioning of the Androgen Receptor in Male Mice
Authors: El Kharraz Sarah , Dubois Vanessa , Launonen Kaisa-Mari , Helminen Laura , Palvimo Jorma J , Libert Claude , Smeets Elien , Moris Lisa , Eerlings Roy , Vanderschueren Dirk , Helsen Christine , Claessens Frank 
Published: July 2022

Abstract
The androgen receptor (AR) plays a central role in the development and maintenance of the male phenotype. The binding of androgens to the receptor induces interactions between the carboxyterminal ligand-binding domain and the highly conserved 23FQNLF27 motif in the aminoterminal domain. The role of these so-called N/C interactions in AR functioning is debated. In vitro assays show that mutating the AR in the 23FQNLF27 motif (called ARNoC) attenuates the AR transactivation of reporter genes, has no effect on ligand binding, but does affect protein-protein interactions with several AR coregulators. To test the in vivo relevance of the N/C interaction, we analyzed the consequences of the genomic introduction of the ARNoC mutation in mice. Surprisingly, the ARNoC/Y mice show a normal male development, with unaffected male anogenital distance and normal accessory sex glands, male circulating androgen levels, body composition, and fertility. The responsiveness of androgen target genes in kidney, prostate, and testes was also unaffected. We thus conclude that the N/C interactions in the AR are not essential for the development of a male phenotype under normal physiological conditions.
Public knowledge of blood cancers
Authors: Gieniec Weronika , Gucwa Magdalena , Galus Adrian , Jurkiewicz Beata 
Published: July 2022

Introduction. Blood cancers are a group of conditions that develop in the bone marrow and/or lymphatic system and include cancers of the hematopoietic system and cancers of the lymphatic system. The key test for blood cancers diagnosing is complete blood count.
The aim of the study was to assess the level of public knowledge about blood cancers and their treatment. The study was conducted in March 2022 by a diagnostic survey method using a proprietary survey questionnaire made available online via Google Forms. The analysis included 311 correctly completed questionnaires.
Results and conclusions. The respondents' level of knowledge about blood cancers and their treatment methods is very low. Nearly half of the respondents perform blood counts too infrequently (every two years or less often). Those with any knowledge of blood cancers (defined as minimal in the knowledge test) performed a blood count every six months, and not less often than once a year. Nearly 1/3 of the respondents do not want to donate bone marrow because they are afraid of the procedure. Of those registered or those who attempted registration, most presented a level of knowledge defined as minimal. The vast majority of respondents would like to see more events to promote blood cancer awareness.
Adolescent idiopathic scoliosis
Authors: Marya Shivan , Tambe Anant D. , Millner Peter A. , Tsirikos Athanasios I. 
Published: July 2022

Adolescent idiopathic scoliosis (AIS), defined by an age at presentation of 11 to 18 years, has a prevalence of 0.47% and accounts for approximately 90% of all cases of idiopathic scoliosis. Despite decades of research, the exact aetiology of AIS remains unknown. It is becoming evident that it is the result of a complex interplay of genetic, internal, and environmental factors. It has been hypothesized that genetic variants act as the initial trigger that allow epigenetic factors to propagate AIS, which could also explain the wide phenotypic variation in the presentation of the disorder. A better understanding of the underlying aetiological mechanisms could help to establish the diagnosis earlier and allow a more accurate prediction of deformity progression. This, in turn, would prompt imaging and therapeutic intervention at the appropriate time, thereby achieving the best clinical outcome for this group of patients. Cite this article: Bone Joint J 2022;104-B(8):915–921.
Epidemiology and characteristics of femoral periprosthetic fractures
Authors:   The COMPOSE Study Team
Published: July 2022

AimsThe aim of this study was to describe the demographic details of patients who sustain a femoral periprosthetic fracture (PPF), the epidemiology of PPFs, PPF characteristics, and the predictors of PPF types in the UK population.MethodsThis is a multicentre retrospective cohort study including adult patients presenting to hospital with a new PPF between 1 January 2018 and 31 December 2018. Data collected included: patient characteristics, comorbidities, anticoagulant use, social circumstances, level of mobility, fracture characteristics, Unified Classification System (UCS) type, and details of the original implant. Descriptive analysis by fracture location was performed, and predictors of PPF type were assessed using mixed-effects logistic regression models.ResultsIn total, 720 femoral PPFs from 27 NHS sites were included. PPF patients were typically elderly (mean 79.9 years (SD 10.6)), female (n = 455; 63.2%), had at least one comorbidity (n = 670; 93.1%), and were reliant on walking aids or bed-/chair-bound prior to admission (n = 419; 61.7%). The study population included 539 (74.9%) hip PPFs, 151 (21.0%) knee PPFs, and 30 (4.2%) dividing type PPFs. For hip (n = 407; 75.5%) and knee (n = 88; 58.3%) arthroplasty UCS B type fractures were most common. Overall, 556 (86.2%) were treated in the presenting hospital and 89 (13.8%) required transfer for treatment. Female sex was the only significant predictor of fracture type (A/B1/C type versus B2/B3) for femoral hip PPFs (odds ratio 0.61 (95% confidence interval 0.41 to 0.91); p = 0.014). Sex, residence type, primary versus revision implant PPF, implant fixation, and time between arthroplasty and PPF were not found to predict fracture type for hip PPFs.ConclusionThis multicentre analysis describes patient and injury factors for patients presenting with femoral PPFs to centres across the UK. These patients are generally elderly and frail, comparable to those sustaining a hip fracture. These data can be useful in planning future services and clinical trials. Cite this article: Bone Joint J 2022;104-B(8):987–996 .
Absorbable versus nonabsorbable sutures for the Krackow suture repair of acute Achilles tendon rupture: a prospective randomized controlled trial
Authors: Park Young H. , Kim Woon , Choi Jung W. , Kim Hak J. 
Published: July 2022

Aims Although absorbable sutures for the repair of acute Achilles tendon rupture (ATR) have been attracting attention, the rationale for their use remains insufficient. This study prospectively compared the outcomes of absorbable and nonabsorbable sutures for the repair of acute ATR. Methods A total of 40 patients were randomly assigned to either braided absorbable polyglactin suture or braided nonabsorbable polyethylene terephthalate suture groups. ATR was then repaired using the Krackow suture method. At three and six months after surgery, the isokinetic muscle strength of ankle plantar flexion was measured using a computer-based Cybex dynamometer. At six and 12 months after surgery, patient-reported outcomes were measured using the Achilles tendon Total Rupture Score (ATRS), visual analogue scale for pain (VAS pain), and EuroQoL five-dimension health questionnaire (EQ-5D). Results Overall, 37 patients completed 12 months of follow-up. No difference was observed between the two groups in terms of isokinetic plantar flexion strength, ATRS, VAS pain, or EQ-5D. No re-rupture was observed in either group. Conclusion The use of absorbable sutures for the repair of acute ATR was not inferior to that of nonabsorbable sutures. This finding suggests that absorbable sutures can be considered for the repair of acute ATRs. Cite this article: Bone Joint J 2022;104-B(8):938–945.
One-year outcome of surgery compared with immobilization in a cast for adults with an undisplaced or minimally displaced scaphoid fracture
Authors: Johnson Nick A. , Fairhurst Caroline , Brealey Stephen D. , Cook Elizabeth , Stirling Euan , Costa Matt , Divall Pip , Hodgson Stephen , Rangan Amar , Dias Joseph J. 
Published: July 2022

Aims There has been an increasing use of early operative fixation for scaphoid fractures, despite uncertain evidence. We conducted a meta-analysis to evaluate up-to-date evidence from randomized controlled trials (RCTs), comparing the effectiveness of the operative and nonoperative treatment of undisplaced and minimally displaced (≤ 2 mm displacement) scaphoid fractures. Methods A systematic review of seven databases was performed from the dates of their inception until the end of March 2021 to identify eligible RCTs. Reference lists of the included studies were screened. No language restrictions were applied. The primary outcome was the patient-reported outcome measure of wrist function at 12 months after injury. A meta-analysis was performed for function, pain, range of motion, grip strength, and union. Complications were reported narratively. Results Seven RCTs were included. There was no significant difference in function between the groups at 12 months (Hedges’ g 0.15 (95% confidence interval -0.02 to 0.32); p = 0.082). The complication rate was higher in the operative group and involved more serious complications. Conclusion We found no difference in functional outcome at 12 months for fractures of the waist of the scaphoid with ≤ 2 mm displacement treated operatively or nonoperatively. The complication rate was higher with operative treatment. Cite this article: Bone Joint J 2022;104-B(8):953–962.
A new prognostic nomogram for heterotopic ossification formation after elbow trauma
Authors: Sun Ziyang , Liu Weixuan , Liu Hang , Li Juehong , Hu Yuehao , Tu Bing , Wang Wei , Fan Cunyi 
Published: July 2022

Aims Heterotopic ossification (HO) is a common complication after elbow trauma and can cause severe upper limb disability. Although multiple prognostic factors have been reported to be associated with the development of post-traumatic HO, no model has yet been able to combine these predictors more succinctly to convey prognostic information and medical measures to patients. Therefore, this study aimed to identify prognostic factors leading to the formation of HO after surgery for elbow trauma, and to establish and validate a nomogram to predict the probability of HO formation in such particular injuries. Methods This multicentre case-control study comprised 200 patients with post-traumatic elbow HO and 229 patients who had elbow trauma but without HO formation between July 2019 and December 2020. Features possibly associated with HO formation were obtained. The least absolute shrinkage and selection operator regression model was used to optimize feature selection. Multivariable logistic regression analysis was applied to build the new nomogram: the Shanghai post-Traumatic Elbow Heterotopic Ossification Prediction model (STEHOP). STEHOP was validated by concordance index (C-index) and calibration plot. Internal validation was conducted using bootstrapping validation. Results Male sex, obesity, open wound, dislocations, late definitive surgical treatment, and lack of use of non-steroidal anti-inflammatory drugs were identified as adverse predictors and incorporated to construct the STEHOP model. It displayed good discrimination with a C-index of 0.80 (95% confidence interval 0.75 to 0.84). A high C-index value of 0.77 could still be reached in the internal validation. The calibration plot showed good agreement between nomogram prediction and observed outcomes. Conclusion The newly developed STEHOP model is a valid and convenient instrument to predict HO formation after surgery for elbow trauma. It could assist clinicians in counselling patients regarding treatment expectations and therapeutic choices. Cite this article: Bone Joint J 2022;104-B(8):963–971.
Exploring food and physical activities between grandparents and their grandchildren. Explorando comidas y actividades físicas entre abuelos y sus nietos.
Authors: Castañeda-García Pedro Javier , Luis-Díaz Aryana , González-Rodríguez Jandir , Gutiérrez-Barroso Josué 
Published: July 2022

Abstract. Given the growing influence of grandparents on their grandchildren’s upbringing, this study analyzes two key health variables shared by these two generations: diet and physical activity. Interviews were conducted with 114 Spanish grandparents with no physical or cognitive limitations. Questions covered sociodemographic characteristics, the types of foods they serve their grandchildren, and the physical activities that they share with them. The foods were categorized by glycemic index according to whether they were more or less likely to favor overweight and obesity, and the physical activities were categorized as dynamic/sedentary and outdoor/indoor. The data were analyzed using Student’s t-test for independent samples and ANOVAS. The results showed that some of the grandparents’ sociodemographic variables—age, educational level, health status, time spent with grandchildren, and distance from their grandchildren—were significantly correlated with the types of foods served and physical activities shared. Grandchildren’s food consumption and level of physical activity can be directly influenced by their grandparents. Family interventions should take into account the fact that certain sociodemographic variables in grandparents may favor either more or less healthy dietary habits and physical behavior. Resumen. Ante la creciente influencia de los abuelos en la crianza de los nietos, en este trabajo se analiza dos variables de salud claves compartidas entre ellos: la alimentación y la actividad física. Se entrevistó a 114 abuelos españoles, sin limitaciones físicas ni cognitivas, y se les preguntó por sus características sociodemográficas, las comidas que proporcionan a sus nietos y las actividades físicas compartidas. Los alimentos correspondían a índices glucémicos que favorecen más el sobrepeso y la obesidad, y lo contrario; y las actividades físicas dinámicas y sedentarias, de exterior e interior. Los datos se analizaron con la prueba t de Student para muestras independientes y con ANOVAS. Los resultados mostraron que algunas variables sociodemográficas de los abuelos como la edad, el nivel educativo, la salud, las horas juntos y la distancia con sus nietos están relacionadas significativamente tanto con los tipos de comida como la actividad física que comparten. Como conclusión, la comida y las actividades físicas de los nietos pueden estar influidas directamente por sus abuelos. Cualquier intervención familiar debería tener en cuenta que ciertas características sociodemográficas de los abuelos podrían favorecer tanto unos tipos de conducta alimentaria y física más saludables, como todo lo contrario.
Factores Psicológicos implicados en la adherencia de personas con alto riesgo de Diabetes Mellitus tipo 2
Authors: Anarte Ortiz María Teresa , Varela Moreno Esperanza 
Published: July 2022

Introducción: Aunque la relación entre factores psicosociales y la adherencia al tratamiento en personas con Diabetes Mellitus Tipo 2 (DM2) ha sido estudiada, no se conocen estudios que analicen éstos factores en el marco de la aplicación de un programa preventivo para personas con alto riesgo de DM2 (ARDM2). El objetivo de este estudio es analizar si existe un perfil psicosocial diferente entre los participantes a un programa de hábitos de vida saludables con ARDM2 en función de su adherencia al mismo, para lo cual se ha realizado una evaluación psicológica exhaustiva, principal novedad que aporta el estudio. Materiales y métodos: El estudio se realizó en una muestra de 173 pacientes con prediabetes que participan en un programa preventivo en hábitos de vida saludable. Las variables psicosociales fueron evaluadas utilizando varias herramientas psicológicas: SCID-1, BDI-II, STAI, COPE, DQOL, MOS-SSS y Apgar. Resultados: El 86,1% de la muestra siguió las recomendaciones de dieta o ejercicio y se clasificaron como adherentes, mientras que el 13,9% no siguieron ninguna y fueron clasificados como no adherentes. Se encontraron diferencias significativas en sintomatología depresiva, ansiedad-estado, calidad de vida y estrategias de afrontamiento entre los dos grupos (adherentes / no adherentes). No se encontraron diferencias significativas en el apoyo social/familiar percibido. Discusión: Estos resultados proporcionan la primera evidencia empírica sobre la utilización de una amplia batería de instrumentos de evaluación psicológica aplicados en un programa preventivo para personas con ARDM2 obteniéndose perfiles diferentes en función de su adherencia al mismo.
Evidencias de Validez de la versión Argentina del Cuestionario de Salud del Paciente -9 (CSP-9).
Authors: Matrángolo Gisela Maricel , Azzollini Susana , Simkin Hugo 
Published: July 2022

El objetivo del presente trabajo es presentar las evidencias de Validez del Patient Health Questionnaire- 9 (PQH.9) para adultos argentinos. El pqh-9 cuenta con 9 items que permiten evaluar sintomatología de Trastorno Depresivo Mayor. En el contexto local, la PQH-9 muestra propiedades psicométricas adecuadas: Indicadores de confiabilidad ω .835 y α .857 y apropiados índices de ajuste, RMSEA: .053, CFI .99. Así también se evaluó la validez externa. presentando un r: .49 y .63 en las distintas dimensiones, del Cuestionario Internacional de Trauma (CTI) que evalua Trastorno de Estrés Postraumático y Estrés Postraumático complejo. Estos resultados proporcionarían indicios de validez externa. Se concluye que la PQH-9 presenta propiedades psicométricas adecuadas para su uso en población argentina.
Antike Zivilgesellschaft. Ein Plädoyer für die Adaption eines Begriffs der Gegenwart
Authors: Pfeilschifter Rene 
Published: July 2022

Zusammenfassung
Zivilgesellschaft ist derjenige Bereich der öffentlichen Sphäre, der jenseits der Familie und diesseits des Staates liegt und vom Güteraustausch des Marktes abgrenzbar ist. Im Diskurs der Gegenwart ist der Begriff hochgradig aufgeladen im Sinne einer politischen Zielsetzung für ein liberal-demokratisches Projekt und eine bessere Gesellschaft. Das mindert den wissenschaftlichen Wert eines an sich für die historische Gesellschaftsbeschreibung nützlichen Modells. Diesen Nutzen zeigt der Aufsatz am Beispiel der Vereine und informellen Gruppen in der römischen Kaiserzeit der ersten beiden nachchristlichen Jahrhunderte auf. Für vormoderne Kulturen vermutet die Forschung meist nicht einmal die Existenz zivilgesellschaftlicher Gruppen. Tatsächlich aber erlaubt das Konzept eine präzise Analyse der Agency gerade der nichtelitären Schichten. Neben den vertikalen Verbindungen, wie sie etwa in der Patronage oder dem Akzeptanzhabitus zum Ausdruck kommen, werden in den lokalen, selbstregelnden Gruppen die horizontalen Bindungskräfte antiker Gesellschaften sichtbar. Die Argumentation des Aufsatzes mündet in den Vorschlag einer normativen Reduktion von „Zivilgesellschaft“: auf Toleranz der gesellschaftlichen Akteure untereinander, auf ein Bemühen um gewaltfreie Konfliktlösung, auf Gemeinsinnigkeit und prinzipielle Anerkennung einer nicht unbedingt demokratischen, aber auch nicht repressiven staatlichen Ordnung. Zusammen mit einer stärkeren Berücksichtigung der urbanen Situierung zivilgesellschaftlicher Gruppen erleichtert ein solchermaßen neugefasstes Konzept den mit historischer Tiefe arbeitenden Disziplinen den transepochalen, interkulturellen Vergleich und erlaubt eine Anwendung auf nichtwestliche Gesellschaften der Gegenwart und der Vergangenheit.
Industriepolitik und transnationale Kooperation. Die Subventionierung des Airbus-Projekts in der Bundesrepublik und Großbritannien
Authors: Ahrens Ralf 
Published: July 2022

Zusammenfassung
Der Beitrag untersucht die staatliche Unterstützung des Airbus-Projekts in Großbritannien und der Bundesrepublik von den 1960er bis zu den 1980er Jahren. Mit dem Passagierflugzeugbau wird eine „Zukunftsindustrie“ in den Blick genommen, die im Strukturwandel dieser Jahrzehnte technologie- und beschäftigungspolitische Hoffnungen auf sich zog und gleichzeitig hochgradig subventionsabhängig war. Nach einer kurzen Erörterung der Trends und Grenzen eines quantitativen Vergleichs werden Formen, Umfang und Motive der finanziellen Förderung der verschiedenen Airbus-Modelle im diachronen Vergleich verfolgt. In beiden Ländern zeigen sich dabei deutliche Kontinuitäten über die verschiedenen Regierungswechsel hinweg und vielfach ähnliche Motivlagen. Die dennoch signifikant höhere Subventionsbereitschaft der bundesdeutschen Regierungen lässt sich, so das Ergebnis, nicht allein aus den nationalen Koordinierungsweisen der Industriepolitik erklären, die sich wiederum verschiedenen „Varieties of Capitalism“ zuordnen lassen. Hinzu kamen unterschiedliche Branchenstrukturen und spezifische außenpolitische Konstellationen.
The Influence of Entrepreneurial Activity's Innovation on Job Creation
Authors: Al-Alawi Abrar Mohammed , Alkindi Kawther Salim , Al-Shukaili Abdullah , Ahmed Essia Ries 
Published: July 2022

The purpose of this study is to explore the influence of innovation in the total early entrepreneurial business activities (TEA) (i.e. nascent and new entrepreneurs) on job creation in the Sultanate of Oman. In other words, the objective of this research is to examine the extent to which current innovation types in entrepreneurial activities have an impact on creating jobs. The TEA innovation will be measured by the ability of the enterprise to adopt new technology and the ability to create new products or services in the market. Based on the existing empirical studies, a conceptual model has been developed accordingly. To achieve the research objective, this study applied the data collected from national Omanis at the individual level using the Global Entrepreneurship Monitor (GEM) data 2020 to test the stated hypotheses. The sample of this study consist of 2000 Omani households who are involved in business entrepreneurial activities. Using structural equation modeling in PLS (SEM-PLS). The results revealed that the innovation in nascent and new entrepreneurs affects the level of created jobs in the Sultanate of Oman. The findings also demonstrate nascent and new entrepreneurs’ innovativeness ability to create jobs reflected significantly on both current and expected creation of jobs.
The Influence of Financial Behaviour on Financial Risk Tolerance In Investment Decision: A Conceptual Paper
Authors: Bunyamin Mubarokah , Abdul Wahab Norwazli 
Published: July 2022

There is a growing stream of research to seek for a solution to improve financial risk tolerance (FRT) in investment decisions, which is most likely conducted from financial institutions and was revealed that there are varieties of factors contribute to this aspect. The literature demonstrated that FRT is considered as the powerful factor that encourages investors’ intentions towards investments. Study shows that the FRT can be improved through positive financial behaviour. Hence it is essential to explore financial behaviour and FRT influences in investment decision from studies around the world and Malaysian market. Therefore, this wide discussion will benefit financial practitioners and institutions in financial practices. In addition, this study surely contribute some additional insights towards existing literature.