bluuebunny/crossref_metadata_2025_split huggingface dataset:
Henri Vieuxtemps, Anton Rubinstein. Duo Concertant for Violin and Piano on Themes from G. Meyerbeer’s “Le Prophète”. Autograph from the Saint Petersburg Conservatory Collection
Authors: Миллер Л.А. , Сомов В.А. 
Published: November 2022

Статья посвящена совместному сочинению двух знаменитых музыкантов — А. Вьётана и А. Г. Рубинштейна, двойной автограф которого, хранящийся в Научно-исследовательском Отделе рукописей Научной музыкальной библиотеки Санкт-Петербургской государственной консерватории имени Н. А. Римского-Корсакова, был ранее неизвестен исследователям. Рассматривается история создания, исполнений, а также ставших уже библиографической редкостью первых изданий Дуэта в России и за рубежом. Затрагиваются вопросы взаимоотношений Вьётана и А. Рубинштейна, их контакты с Дж. Мейербером, российскими и европейскими издательскими фирмами (М. Бернард, «Сыновья Шотта», «Рикорди»). Привлечение документальных источников позволяет уточнить и дополнить новыми сведениями уже известные факты биографий выдающихся музыкантов. Публикация приурочена к 160-летию основанной А. Г. Рубинштейном Санкт-Петербургской консерватории.
The article is devoted to the collaboration of two famous musicians — Henri Vieuxtemps and Anton Rubinstein, whose double autograph, kept in the Research Department of Manuscripts of the Library of the Saint Petersburg Rimsky-Korsakov State Conservatory, was previously unknown to researchers. The authors discuss the history of creation, dedication, performances, as well as the first editions of the Duet in Russia and abroad, which have already become a bibliographic rarity. The article also covers history of mutual relations of the musicians, their contacts with J. Meyerbeer, Russian and foreign publishing companies (M. Bernard, “Sons of Schott”, “Ricordi”). The documentary sources allow us to clarify the already known facts of the biographies of the musicians and supplement them with new information. The publication is time to the 160th anniversary of the Saint Petersburg Conservatory founded by Anton Rubinstein.
Flattening and Unflattening
Authors: Meer Julia 
Published: November 2022

In my paper I undertake basic research on comics and knowledge transfer by comparing scientific comics with other forms of visualization in (the history of) science. In doing so, I elaborate the central characteristics of comics in reference to current research, and relate them to philosophical theories of images by arguing that the specific materiality of the images in general, and in comics in particular, has received too little attention so far. The central thesis is that materiality is decisive for images not only to illustrate scientific theories but to become knowledge-generating media themselves.
Double sequential external defibrillation versus standard defibrillation in refractory ventricular fibrillation: A systematic review and meta-analysis
Authors: Li Yongkai , He Xiaojing , Li Zhuanyun , Li Dandan , Yuan Xin , Yang Jianzhong 
Published: November 2022

IntroductionDouble sequential external defibrillation (DSED) in cardiopulmonary resuscitation has shown different results in comparison with standard defibrillation in the treatment of refractory ventricular fibrillation (RVF). This review aims to compare the advantages of DSED with standard defibrillation in the treatment of refractory ventricular fibrillation.Materials and methodsPubMed, Embase, Web of Science, and Cochrane Library were searched from inception to May 1, 2022. Studies included adult patients who developed RVF. The study used random-effects and fixed-effects models for meta-analysis, which was reported by risk ratio (RR) with 95% confidence interval (CI), mean difference (MD), or standardized mean difference (SMD). The risk of bias in individual studies was assessed using the Robins-I tool for observational studies and the Cochrane Risk of Bias 2 (ROB-2) tool for clinical trials. Primary outcomes included the termination of RVF, prehospital return of spontaneous circulation (ROSC), survival to hospital admission, survival to hospital discharge, and good neurological recovery. Secondary outcomes included age, total defibrillation attempts, emergency medical system arrival time, and dose of epinephrine and amiodarone used.ResultsIn this systematic review and meta-analysis, 10 studies containing 1347 patients with available data on treatment outcomes were included. The pooled estimate was (RR 1.03, 95% CI, 0.89 to 1.19; Z = 0.42, P = 0.678 &gt; 0.05) for Termination of RVF, (RR 0.84, 95% CI, 0.63 to 1.11; Z = 1.23, P = 0.219 &gt; 0.05) for ROSC, (RR 0.86, 95% CI, 0.69 to 1.06; Z = 1.4, P = 0.162 &gt; 0.05) for survival to hospital admission, (RR 0.77, 95%CI, 0.52 to 1.15; Z = 1.26, P = 0.206 &gt; 0.05) for survival to hospital discharge, (RR 0.65, 95%CI, 0.35 to 1.22; Z = 1.33, P = 0.184 &gt; 0.05) for good neurologic recovery, (MD −1.01, 95%CI, −3.07 to 1.06; Z = 0.96, P = 0.34 &gt; 0.05) for age, (MD 2.27, 95%CI, 1.80 to 2.73; Z = 9.50, P = 0.001 &lt; 0.05) for total defibrillation attempts, (MD 1.10, 95%CI, −0.45 to 66; Z = 1.39, P = 0.16 &gt; 0.05) for emergency medical system arrival time, (SMD 0.34, 95%CI, 0.17 to 0.50; Z = 4.04, P = 0.001 &lt; 0.05) for epinephrine, and (SMD −0.30, 95%CI, −0.65 to −0.05; Z = 1.66, P = 0.1 &gt; 0.05) for amiodarone.ConclusionWe discovered no differences between DSED and standard defibrillation in termination of RVF, prehospital return of spontaneous circulation, survival to hospital admission, survival to hospital discharge, good neurological outcome, emergency medical system arrival time, and amiodarone doses in patients with RVF. There were some differences in the number of defibrillations and epinephrine doses utilized during resuscitation.Systematic review registration[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=329354], identifier [CRD42022329354].
Diverse cooling effects of green space on urban heat island in tropical megacities
Authors: Li Chunbo , Lu Linlin , Fu Zongtang , Sun Ranhao , Pan Luyang , Han Liying , Guo Huadong , Li Qingting 
Published: November 2022

Cities in tropical regions are experiencing high heat risks by overlaying the urban heat island (UHI) effect. Urban green space (UGS) can provide local cooling effect and reduce UHI. However, there still lack a comprehensive exploration of the characteristics of UHI and cooling effect of UGS due to high cloud coverage and limited number of available remote sensing observations. In this study, the enhanced spatial and temporal adaptive reflectance data fusion method was employed to develop an enhanced land surface temperature data in winter seasons in three tropical megacities, Dhaka, Kolkata, and Bangkok. The spatiotemporal variations of surface urban heat island (SUHI) were explored from 2000 to 2020 with a 5-years interval. The optimal size of UGS associated with its cooling effects was assessed by using the threshold value of efficiency (TVoE). The relationship between the intensity and range of urban cooling island (UCI) and four landscape metrics of green space patches, total area (P_Area), shape index (P_SI), normalized difference vegetation index (P_NDVI), and land surface temperature (P_LST), were analyzed. The results show that the average SUHI intensity increased by 0.98°C, 1.42°C, and 0.73°C in Dhaka, Kolkata, and Bangkok, respectively, from 2000 to 2020. The maximum intensity of UCI ranges from 4.83°C in Bangkok to 8.07°C in Kolkata, and the maximum range of UCI varies from 300 m in Bangkok to 420 m in Kolkata. The optimal size of green space is 0.37 ha, 0.77 ha, and 0.42 ha in Dhaka, Kolkata, and Bangkok, respectively. The P_NDVI and P_Area had significant positive effects on UCI intensity and range, while the background temperature had significant negative effects. With higher background temperature, the optimal patch size of UGS is larger. This study provides useful information for developing effective heat mitigation and adaptation strategies to enhance climate resilience in tropical cities.
Loss of GABA co-transmission from cholinergic neurons impairs behaviors related to hippocampal, striatal, and medial prefrontal cortex functions
Authors: Goral R. Oliver , Harper Kathryn M. , Bernstein Briana J. , Fry Sydney A. , Lamb Patricia W. , Moy Sheryl S. , Cushman Jesse D. , Yakel Jerrel L. 
Published: November 2022

Introduction: Altered signaling or function of acetylcholine (ACh) has been reported in various neurological diseases, including Alzheimer’s disease, Tourette syndrome, epilepsy among others. Many neurons that release ACh also co-transmit the neurotransmitter gamma-aminobutyrate (GABA) at synapses in the hippocampus, striatum, substantia nigra, and medial prefrontal cortex (mPFC). Although ACh transmission is crucial for higher brain functions such as learning and memory, the role of co-transmitted GABA from ACh neurons in brain function remains unknown. Thus, the overarching goal of this study was to investigate how a systemic loss of GABA co-transmission from ACh neurons affected the behavioral performance of mice.Methods: To do this, we used a conditional knock-out mouse of the vesicular GABA transporter (vGAT) crossed with the ChAT-Cre driver line to selectively ablate GABA co-transmission at ACh synapses. In a comprehensive series of standardized behavioral assays, we compared Cre-negative control mice with Cre-positive vGAT knock-out mice of both sexes.Results: Loss of GABA co-transmission from ACh neurons did not disrupt the animal’s sociability, motor skills or sensation. However, in the absence of GABA co-transmission, we found significant alterations in social, spatial and fear memory as well as a reduced reliance on striatum-dependent response strategies in a T-maze. In addition, male conditional knockout (CKO) mice showed increased locomotion.Discussion: Taken together, the loss of GABA co-transmission leads to deficits in higher brain functions and behaviors. Therefore, we propose that ACh/GABA co-transmission modulates neural circuitry involved in the affected behaviors.
Interventions for zoster-associated pain: A retrospective study based on the clinical database
Authors: Chen Lu , Li Jun , Liu Hui , Yang Pingliang , Zuo Yunxia , Ye Ling 
Published: November 2022

BackgroundHerpes zoster (HZ)-associated pain can lead to severe pain and reduced quality of life. Exploring effective treatment and the risk factors of zoster-associated pain has become important.MethodsInterventions including nerve block, radiofrequency, and thermocoagulation were used for zoster-associated pain. The data of 131 patients with HZ and 230 patients with postherpetic neuralgia (PHN) were collected at baseline, 2 weeks, 3, 6, and 12 months after the intervention. Visual analog scale (VAS) and Brief Pain Inventory (BPI) scores at different time points were analyzed by two-way repeated measures ANOVA with Group as the between-subject variable (different pain durations and areas), Time as the within-subject variable (baseline, 2 weeks, 3 months, 6 months, and 12 months), and Group × Time as the two-way interaction. Besides, the effective rate, adverse effects, and medication were also recorded. The risk factors of PHN were analyzed by logistic regression.ResultsA total of 25 (19.08%) patients with HZ continued to have pain in the initially affected area after 3 months. The VAS scores and the BPI quality of life scores of patients with HZ-associated pain were significantly reduced from baseline to 2 weeks, 3, 6, and 12 months after the interventions. There was no significant difference in VAS and BPI scores in different pain areas and pain durations. No significant Group × Time interaction was observed. Age, diabetes mellitus, and immune-related diseases were risk factors of PHN.ConclusionInterventions could significantly improve the pain degree and life quality of patients with zoster-associated pain, and the positive effect of intervention did not change with pain duration and area. Advanced age, diabetes, and immune-related diseases are risk factors of PHN.
Iron metabolism patterns in non-anemic patients with myasthenia gravis: A cross-sectional and follow-up study
Authors: Li Ke , Hou Li'an , Tan Ying , Huang Yangyu , Shi Jiayu , Han Jianhua , Yan Jingwen , Guan Yuzhou 
Published: November 2022

Background and purposeIron metabolism in myasthenia gravis (MG) and factors associated with it are explored by few published studies. Therefore, this study aimed to compare iron metabolism patterns between patients with MG and healthy individuals as well as between the same group of patients before and after immunotherapy, and to identify predictors of iron metabolism disorders in MG.Materials and methodsFor this study, 105 patients and healthy individuals were included at baseline, after which paired parametric and non-parametric tests were adopted to compare their iron metabolism patterns, and multivariate binary logistic regression was used to identify predictors of iron metabolism disorders. Patients with MG were then followed up for 12 ± 3 months to explore alterations in their iron metabolism patterns after starting immunotherapy with the help of paired tests.ResultsNon-anemic immunotherapy-naive patients with MG had significantly lower serum iron (SI) and transferrin saturation (TS) levels than healthy individuals. Premenopausal female was significantly associated with SI &lt; 65 μg/dL and iron deficiency in these patients. However, iron metabolism parameters did not significantly alter after around 12 months of immunotherapy in patients with MG.ConclusionIron inadequacy was present in patients with MG, particularly premenopausal female patients, and it would hardly improve after immunotherapy. Given the significant role of iron in human body, it should be given more attention in patients with MG.
Remote programming for subthalamic deep brain stimulation in Parkinson's disease
Authors: Chen Si , Xu Shu-jun , Li Wei-guo , Chen Teng , Li Chao , Xu Shuo , Yang Ning , Liu Yi-ming 
Published: November 2022

IntroductionDeep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective for the treatment of Parkinson's disease (PD). Moreover, remote programming is widely used in Mainland China. This necessitates evaluating the ability of remote programming to achieve the ideal postoperative effect. Therefore, we aimed to retrospectively evaluate the effects of different programming modes on the effectiveness of STN-DBS 12 months postoperatively in patients with PD.MethodsClinical data were collected retrospectively, before and 12 months after surgery, in 83 patients with PD. Based on the programming modes voluntarily selected by the patients during 12 months postoperatively, they were divided into three groups, namely remote programming alone, hospital programming alone, and hospital + remote programming. We compared the programming data and the effects of different programming methods on STN-DBS-related improvements 12 months postoperatively among these groups. Furthermore, we analyzed STN-DBS-related improvements at 12 months postoperatively in 76 patients.ResultsThe effectiveness of STN-DBS was not influenced by the three programming modes. The postoperative Movement Disorder Society Unified Parkinson's Disease Rating Scale scores did not reveal statistically significant differences between the remote alone and hospital alone programming groups, except for motor examination. The postoperative decline in the levodopa equivalent daily dose was most apparent in the hospital programming alone group. The programming frequency of the hospital + remote programming group was considerably higher than that of the remaining groups. Seventy-six patients with PD displayed good STN-DBS surgical efficacy.ConclusionProgramming modes do not influence the short-term efficacy of STN-DBS, and remote programming can yield a satisfactory surgical effect.
Twenty-four-hour time-use composition and cognitive function in older adults: cross-sectional findings of the ACTIVate study
Authors: Mellow Maddison L. , Dumuid Dorothea , Wade Alexandra T. , Stanford Ty , Olds Timothy S. , Karayanidis Frini , Hunter Montana , Keage Hannah A. D. , Dorrian Jillian , Goldsworthy Mitchell R. , Smith Ashleigh E. 
Published: November 2022

IntroductionPhysical activity, sedentary behaviour and sleep are associated with cognitive function in older adults. However, these behaviours are not independent, but instead make up exclusive and exhaustive components of the 24-h day. Few studies have investigated associations between 24-h time-use composition and cognitive function in older adults. Of these, none have considered how the quality of sleep, or the context of physical activity and sedentary behaviour may impact these relationships. This study aims to understand how 24-h time-use composition is associated with cognitive function across a range of domains in healthy older adults, and whether the level of recreational physical activity, amount of television (TV) watching, or the quality of sleep impact these potential associations.Methods384 healthy older adults (age 65.5 ± 3.0 years, 68% female, 63% non-smokers, mean education = 16.5 ± 3.2 years) participated in this study across two Australian sites (Adelaide, n = 207; Newcastle, n = 177). Twenty-four-hour time-use composition was captured using triaxial accelerometry, measured continuously across 7 days. Total time spent watching TV per day was used to capture the context of sedentary behaviours, whilst total time spent in recreational physical activity was used to capture the context of physical activity (i.e., recreational accumulation of physical activity vs. other contexts). Sleep quality was measured using a single item extracted from the Pittsburgh Sleep Quality Index. Cognitive function was measured using a global cognition index (Addenbrooke’s Cognitive Examination III) and four cognitive domain composite scores (derived from five tests of the Cambridge Neuropsychological Test Automated Battery: Paired Associates Learning; One Touch Stockings of Cambridge; Multitasking; Reaction Time; Verbal Recognition Memory). Pairwise correlations were used to describe independent relationships between time use variables and cognitive outcomes. Then, compositional data analysis regression methods were used to quantify associations between cognition and 24-h time-use composition.ResultsAfter adjusting for covariates and false discovery rate there were no significant associations between time-use composition and global cognition, long-term memory, short-term memory, executive function, or processing speed outcomes, and no significant interactions between TV watching time, recreational physical activity engagement or sleep quality and time-use composition for any cognitive outcomes.DiscussionThe findings highlight the importance of considering all activities across the 24-h day against cognitive function in older adults. Future studies should consider investigating these relationships longitudinally to uncover temporal effects.
The effect of ketamine on cognition, anxiety, and social functioning in adults with psychiatric disorders: A systematic review and meta-analysis
Authors: Marchi Mattia , Magarini Federica Maria , Galli Giacomo , Mordenti Federico , Travascio Antonio , Uberti Daniele , De Micheli Edoardo , Pingani Luca , Ferrari Silvia , Galeazzi Gian Maria 
Published: November 2022

BackgroundIt has been shown that ketamine can improve suicidality and depression. Evidence for other dimensions of psychopathology is lacking. We undertook a systematic review to investigate the effect of ketamine on cognition, anxiety, quality of life, and social functioning in adults with psychiatric disorders.MethodsPubMed (Medline), Scopus, PsycINFO, and EMBASE were searched up to April 2022. Randomized controlled trials (RCTs) on ketamine [or its S (+) enantiomer] reporting data on cognition, anxiety, quality of life, social functioning in adults with psychiatric disorders were included. Standardized mean difference (SMD) was used for summarizing continuous outcomes.ResultsTwenty-two reports were included in the final selection, of which 20, corresponding to 1,298 participants, were included in the quantitative synthesis. Affective disorders were the predominant diagnostic category. Median follow-up time was 21 days. The evidence was rated moderate to very low. In most trials, ketamine was administered intravenously or as adjuvant to electro-convulsant therapy (ECT). Only 2 trials of intranasal esketamine were identified. The effect of ketamine on depression was confirmed (SMD: −0.61 [95% CI: −1.06; −0.16]). Furthermore, by pooling results of 6 RCTs, ketamine may be effective in reducing anxiety symptoms (SMD: −0.42 [95% CI: −0.84; 0.003]), particularly when administered not within ECT (5 trials; SMD: −0.58 [95% CI: −1.07; −0.09]). However, there was moderate heterogeneity of results. Patients treated with ketamine also had an improvement in social functioning (SMD: −0.31 [95% CI: −0.52; −0.10]), although the estimate was based only on 2 studies. No difference to comparators was found with respect to cognition and quality of life.ConclusionAlongside the antidepressant effect, ketamine may also improve anxiety and social functioning in adults with affective disorders.
A double-blinded, randomized controlled clinical trial of hydrogen inhalation therapy for idiopathic sudden sensorineural hearing loss
Authors: Okada Masahiro , Ogawa Hideo , Takagi Taro , Nishihara Eriko , Yoshida Tadashi , Hyodo Jun , Shinomori Yusuke , Honda Nobumitsu , Fujiwara Takashi , Teraoka Masato , Yamada Hiroyuki , Hirano Shin-ichi , Hato Naohito 
Published: November 2022

BackgroundHydrogen (H2) has been reported to be effective in reducing hearing loss due to several causes in animal studies. However, no study has examined the effectiveness of H2 in treating hearing loss in humans. Thus, we investigated whether H2 is effective for the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL).Materials and methodsWe conducted a double-blind randomized controlled trial at six hospitals between June 2019 and March 2022. The study protocol and trial registration have been published in the Japan Registry of Clinical Trials (jRCT, No. jRCTs06119004). We randomly assigned patients with ISSNHL to receive either H2 (H2 group) or air as a placebo (control group) through inhalation combined with the administration of systemic glucocorticoids and prostaglandin E1. The primary outcome was the hearing threshold and changes in hearing threshold 3 months after therapy. In contrast, the secondary outcomes included the proportion of patients with a good prognosis (complete recovery or marked improvement).ResultsSixty-five patients with ISSNHL (31 and 34 in the H2 and control groups, respectively) were included in this study. The hearing threshold 3 months after treatment was not significantly different between the groups; 39.0 decibels (dB) (95% confidence interval [CI]: 28.7–49.3) and 49.5 dB (95% CI: 40.3–58.7) in the H2 and control groups, respectively. In contrast, the changes in hearing threshold 3 months after treatment was 32.7 dB (95% CI: 24.2–41.3) and 24.2 dB (95% CI: 18.1–30.3) in the H2 and control groups, respectively. Consequently, the changes in hearing threshold were significantly better in the H2 group than in the control group (P = 0.048). However, no adverse effects due to the inhalation of H2 gas have been reported.ConclusionThis is the first study to investigate the efficacy of H2 for the treatment of ISSNHL in humans. The results suggest that H2 therapy may be effective for ISSNHL treatment.Clinical trial registration[https://jrct.niph.go.jp/re/reports/detail/10442], identifier [jRCTs06119004].