bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurogenomic landscape associated with status-dependent cooperative behavior
Authors: Bolton Peri E. , Ryder T. Brandt , Dakin Roslyn , Houtz Jennifer L. , Moore Ignacio T. , Balakrishnan Christopher N. , Horton Brent M. 
Published: October 2022

AbstractThe neurogenomic mechanisms mediating male-male reproductive cooperative behaviors are unknown. We leveraged extensive transcriptomic and behavioral data on a neotropical bird (Pipra filicauda) that perform cooperative courtship displays to understand these mechanisms. Cooperative display is modulated by testosterone, it promotes cooperation in non-territorial birds, but suppresses cooperation in territory holders. We sought to understand the neurogenomic underpinnings of these three related traits: social status, cooperative behavior, and testosterone phenotype. To do this, we profiled gene expression in 10 brain nuclei spanning the social decision-making network (SDMN), and two key endocrine tissues that regulate social behavior. We associated gene expression with each bird’s behavioral and endocrine profile derived from three years of repeated measures taken from free-living birds in the Ecuadorian Amazon. We found distinct landscapes of constitutive gene expression were associated with social status, testosterone phenotype, and cooperation, reflecting the modular organization and engagement of neuroendocrine tissues. Sex-steroid and neuropeptide signaling appeared to be important in mediating status-specific relationships between testosterone and cooperation, suggesting shared regulatory mechanisms with male aggressive and sexual behaviors. We also identified differentially regulated genes involved in cellular activity and synaptic potentiation, suggesting multiple mechanisms underpin these genomic states. Finally, we identified SDMN-wide gene expression differences between territorial and floater males that could form the basis of “status-specific” neurophysiological phenotypes, potentially mediated by testosterone and growth hormone. Overall, our findings provide new, systems-level insights into the mechanisms of cooperative behavior and suggest that differences in neurogenomic state are the basis for individual differences in social behavior.
Emergency hematopoiesis proceeds without contribution of hematopoietic stem cells
Authors: Munz Clara M. , Dressel Nicole , Chen Minyi , Grinenko Tatyana , Roers Axel , Gerbaulet Alexander 
Published: October 2022

SummaryHematopoietic stem cells (HSCs) are the ultimate source of blood and immune cells. Under homeostatic conditions, these cells are considered a quiescent reserve population. However, it is not clear to what extent HSCs participate in emergency responses. Herein, we use fate mapping and proliferation tracking mouse models, which cumulatively record HSC activity in situ. We observed no direct contribution of HSCs to mature blood cell regeneration in response to common hematopoietic emergencies, including inflammation or blood loss. Innate immune training, in which HSCs were proposed to store and integrate information on previous infections, did not alter HSC activity upon secondary exposure. Only severe myeloablation resulted in a robust increase of HSC contribution. Our data demonstrates that HSCs do not directly participate in the regeneration of mature blood cells and therefore do not represent a reserve population to compensate for physiological hematopoietic perturbations.
CasTuner: a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression
Authors: Noviello Gemma , Gjaltema Rutger A. F. , Schulz Edda G. 
Published: October 2022

AbstractCertain cellular processes are dose-dependent, requiring a specific quantity of gene products or a defined stoichiometry between them. This is exemplified by haploinsufficiency or by the need for dosage compensation for X-linked genes between the sexes in many species. Understanding dosage-sensitive processes requires the ability to perturb endogenous gene products in a quantitative manner. Here we present CasTuner, a CRISPR-based toolkit that allows analog tuning of endogenous gene expression. In the CasTuner system, activity of Cas-derived repressors is controlled through a FKBP12F36Vdegron domain and can thereby be quantitatively tuned by titrating the small molecule degrader dTAG-13. The toolkit can be applied at the transcriptional level, using the histone deacetylase hHDAC4 fused to dCas9, or at the post-transcriptional level, using the RNA-targeting CasRx. To optimise efficiency, inducibility and homogeneity of repression we target a fluorescently tagged endogenous gene,Esrrb, in mouse embryonic stem cells. Through flow cytometry, we show that CasTuner allows analog tuning of the target gene in a homogeneous manner across cells, as opposed to the widely used KRAB repressor domain, which exhibits a digital mode of action. We quantify repression and derepression dynamics for CasTuner and use it to measure dose-response curves between the pluripotency factor NANOG and several of its target genes, providing evidence for target-specific dose dependencies. CasTuner thus provides an easy-to-implement tool to perturb gene expression in an inducible, tunable and reversible manner and will be useful to study dose-responsive processes within their physiological context.
Reciprocal inflammatory signaling in an ex-vivo explant model for neurofibromatosis type 1-related cutaneous neurofibromas
Authors: Grit Jamie , Turner Lisa , Essenburg Curt , Dischinger Patrick , Shurlow Nate , Pate Matt , Graveel Carrie , Steensma Matt 
Published: October 2022

AbstractCutaneous neurofibromas (CNF) are benign tumors that occur in the dermis of individuals with neurofibromatosis type 1 (NF), an inherited tumor predisposition syndrome. CNFs cause disfigurement, pain, burning, and itching, resulting in reduced quality of life in NF patients. However, due to their benign nature there are few in vitro or in vivo models of CNFs, which has limited the research of CNF biology and drug discovery efforts. To address this, we developed a patient derived explant (PDE) ex vivo culture model of CNF tumors and normal skin from NF patients. CNF PDEs remain viable in culture for over 9 days and recapitulate the cellular composition and molecular signaling of CNFs. We identified reciprocal inflammatory signaling in CNF PDEs, in which tumors rely on either prostaglandin or leukotriene mediated signaling pathways. Ex vivo glucocorticoid treatment reduced expression of pro-inflammatory genes, confirming CNF PDEs are a useful model for mechanistic studies and preclinical drug testing.
Untangling the relationship between work pressure and emotions in social media: a quantitative empirical study of construction industry
Authors: Liao Liping , Wu Zhijiang 
Published: October 2022

PurposeThe booming social media attracts construction professionals (CPs) to express emotions caused by work pressure (WP) through online behaviors. Previous works focus on the analysis of WP and emotions but do not adequately consider how WP can be reflected through online emotions. Thus, this study aims to attempt to explore the quantitative relationship between online emotional intensity and WP.Design/methodology/approachThis study developed a linguistic-sticker (LS) model to quantitatively evaluate the sentiment intensity of posts published on social media. Moreover, the authors designed two econometric models of ordinary least squares regression and negative binomial regression to test the hypothesis.FindingsThe research found that posts with stronger negative sentiment (or positive sentiment) indicate that CPs face higher (or lower) WP. Besides, there is a negative bias between the sentiment intensity of posts and the comment quantity.Practical implicationsThe positive correlation between sentiment intensity of posts and WP has been confirmed, which indicates that construction managers should pay more attention to CPs' behavior on social media, and take a more direct way to analyze work-related online behavior (e.g. posting, commenting). The dynamic monitoring of emotion-related posts also provides a direct basis for the management team to learn about CP's pressure status and propose measures to reduce their negative emotions. Furthermore, the emotional posts published by CPs on social media provide a direct basis for team managers to obtain their psychological state.Originality/valueThe research contributes to incorporating CPs' emotions into the LS model and to providing information systems artifacts and new findings on the analysis of WP and online emotions.
Limited usefulness of firm-provided cybersecurity information in institutional investors’ investment analysis
Authors: Fortin Anne , Héroux Sylvie 
Published: October 2022

Purpose
The purpose of this study is to examine how financial analysts deal with cybersecurity information in their investment analysis process and whether they find cybersecurity disclosures in companies’ financial reports useful.

Design/methodology/approach
Investment managers/financial analysts and chief information security officers (CISOs) at seven institutional investors were interviewed.

Findings
Not all financial analysts consider cybersecurity risk in their investment analyses. Those who do look at company strategy, how the company integrates cybersecurity into its processes and whether it has certified its cybersecurity information. The financial analysts use this qualitative information to adjust the results of their quantitative analysis. They do not find boilerplate or cursory cybersecurity information in financial reports to be useful. In fact, they view it as unreliable and prefer drawing on other information sources to assess the company’s cybersecurity risk.

Practical implications
The results of this study highlight to securities regulators that reported cybersecurity information is of limited usefulness. Regulators are challenged to revisit their disclosure requirements. Companies wishing to improve the usefulness of their cybersecurity information should provide more company-specific information.

Originality/value
To the best of the authors’ knowledge, this study is the first to look at financial analysts’ perception of cybersecurity-related information. It complements findings from prior market studies by adding new insights into the way influential market participants deal with this information in their investment analysis process.
An exploratory investigation of technology-assisted dining experiences from the consumer perspective
Authors: Gu Qiushi , Li Minglong , Huang Songshan (Sam) 
Published: October 2022

Purpose
The use of modern technologies in restaurants has become a trend. For food and beverage services, embracing new technologies helps solve the dilemmas of increasing labor costs and the high level of staff turnover in the industry. However, knowledge regarding how consumers perceive and evaluate technology-assisted dining experiences (TADEs) is limited. This study aims to conceptualize and operationalize TADEs while considering increasing technological applications in restaurants.

Design/methodology/approach
This study conducted in-depth interviews with 71 restaurant consumers in Nanjing and Wuhan, China. Following the interviews, this study carried out a survey and identified the factor structure of TADEs.

Findings
The in-depth interviews identified 26 attributes of TADEs. An analysis of the survey data identified four important aspects (with 21 items) of TADEs, namely, novelty and fashion, convenience, high efficiency and restrictions and possible risks.

Practical implications
Hospitality managers can implement the suggested measures for dining service design and technology management to improve the experiences of customers.

Originality/value
These findings have theoretical implications for the new phenomenon of technology-integrated dining, the application of technology and consumer management in the catering industry.
Supervisor incivility and turnover intention of the employees in the hospitality industry of China
Authors: Yin Jie , Ji Yingchao , Ni Yensen 
Published: October 2022

Purpose
As supervisor incivility and its negative effect may impact employees’ psychological health and even the sustainable development of hospitality enterprises, this study aims to explore the channels through which it affects employee turnover intention in China’s hospitality industry and suggest possible mitigation measures.

Design/methodology/approach
This study adopted exploratory factor analysis, measurement model analysis and the mediation and moderation model and used SPSS and PROCESS for the analysis.

Findings
This study found that the impact of supervisor incivility on the employees’ turnover intention would be through employees’ ego depletion and revealed that organizational support would alleviate such a negative effect. However, organizational support might not mitigate the impact of supervisor incivility on the employees’ ego depletion, which is inconsistent with previous studies. This study inferred that organizational support might be somewhat related to organizational pressure, thereby enhancing the impact of supervisor incivility on the employees’ ego depletion.

Research limitations/implications
This study not only enriches incivility literature but also suggests new insights into the mixed role of organizational support.

Originality/value
Unlike previous studies that mainly focused on workplace pressure from colleagues or customers, this study broadens our understanding of the employees’ turnover intention affected by supervisors’ workplace incivility and the mixed role of organizational support.
Psychosocial indicators of suicidal ideation among acid attack survivors
Authors: Asif Shakeela , Khan Soulat , Butt Tayyab Ali , Mehmood Anisa , Zulfiqar Aimen , Mubashar Tahira 
Published: October 2022

Purpose
This study aims to probe the relationship of facial disfigurement, stigmatization, burdensome, hopelessness and suicidal ideation in acid attack survivors and to scrutinize the mediating role of perceived burdensome and hopelessness in connection between facial disfigurement, social stigmatization and suicidal ideation among acid attack survivors.

Design/methodology/approach
Data was collected from Holy Family Hospital which is located in Rawalpindi, Pakistan, Acid Survivors Foundation and social media sites. Purposive sampling technique was used to collect the sample. Sample comprised of N = 74 acid attack survivors. English version of discrimination and stigma scale, interpersonal needs questionnaire perceived burdensome scale, suicidal ideation attributes scale, Beck hopelessness scale and observer-rated facial disfigurement scale were used for the assessment. Statistical analysis includes correlation and mediation analysis through process macro.

Findings
Results indicated significant positive relationship between facial disfigurements, unfair treatment, stopping self and perceived burdensome with suicidal ideation, whereas overcoming stigma, hopelessness and positive treatment present a negative relationship with suicidal ideation. Results of the current study also showed that burdensome and hopelessness appear as significant mediator in association between facial disfigurement, social discrimination and suicidal ideation. This study provides the awareness about how by decreasing the hopelessness and perceived burdensome and resolving social stigmatization can minimize suicidal ideation and risks accompanying it.

Originality/value
This research covers a topic that violates human rights, it is a topic that never gets old and people are still facing its effects.
Modified invasive weed optimization-based path exploration for mobile robot
Authors: Dhal Ipsit Kumar , Kumar Saroj , Parhi Dayal R. 
Published: October 2022

PurposeThis study aims to modify a nature-based numerical method named the invasive weed optimization (IWO) method for mobile robot path planning in various complex environments.Design/methodology/approachThe existing IWO method is quick in converging to a feasible solution but in a complex environment; it takes more time as well as computational resources. So, in this paper, the computational part of this artificial intelligence technique is modified with the help of recently developed evolution algorithms like particle swarm optimization, genetic algorithm, etc. Some conditional logic statements were used while doing sensor-based mapping for exploring complex paths. Implementation of sensor-based exploration, mathematical IWO method and prioritizing them for better efficiency made this modified IWO method take complex dynamic decisions.FindingsThe proposed modified IWO is better for dynamic obstacle avoidance and navigating a long complex map. The deviation of results in simulation and experiments is less than 5.5%, which validates a good agreement between simulation and real-time testing platforms.Originality/valueAs per a deep literature review, it has found that the proposed approach has not been implemented on the Khepera-III robot for smooth motion planning. Here a dynamic obstacle mapping feature is implemented. A method to selectively distribute seeds instead of a random normal distribution is also implemented in this work. The modified version of IWO is coded in MATLAB and simulated through V-Rep simulation software. The integration of sensors was done through logical conditioning. The simulation results are validated using real-time experiments.
Logistics 4.0 in warehousing: a conceptual framework of influencing factors, benefits and barriers
Authors: Perotti Sara , Bastidas Santacruz Roman Felipe , Bremer Peik , Beer Jakob Emanuel 
Published: October 2022

PurposeIn the last decade, the Industry 4.0 paradigm had started to rapidly expand to the logistics domain. However, Logistics 4.0 is still in an early adoption stage: some areas such as warehousing are still exploring its applicability, and the technological implementation of this paradigm can become fuzzy. This paper addresses this gap by examining the relationship among influencing factors, barriers, and benefits of Logistics 4.0 technologies in warehousing contexts.Design/methodology/approachStarting from a Systematic Literature Review (SLR) approach with 56 examined documents published in scientific journals or conference proceedings, a conceptual framework for Logistics 4.0 in warehousing is proposed. The framework encompasses multiple aspects related to the potential adopter’s decision-making process.FindingsInfluencing factors toward adoption, achievable benefits, and possible hurdles or criticalities have been extensively analyzed and structured into a consistent picture. Company’s digital awareness and readiness result in a major influencing factor, whereas barriers and criticalities are mostly technological, safety and security, and economic in nature. Warehousing process optimization is the key benefit identified.Originality/valueThis paper addresses a major gap since most of the research has focused on specific facets, or adopted the technology providers’ perspective, whereas little has been explored in warehousing from the adopters’ view. The main novelty and value lie in providing both academics and practitioners with a thorough view of multiple facets to be considered when approaching Logistics 4.0 in logistics facilities.
Cross-actor pallet exchange platform for collaboration in circular supply chains
Authors: Lehner Roland , Elbert Ralf 
Published: October 2022

PurposePallets ensure efficient processes in logistics and are exchanged between the different actors, while passing through various supply chains several times. In common practice, the exchange is often not directly carried out on site, e.g. due to a lack of time, so that additional trips and new pallet purchases become necessary. To reduce these negative effects, a digital cross-actor platform is designed, and its potential is investigated.Design/methodology/approachThe authors developed an agent-based simulation model with mathematical optimization. Using experience from practitioners, as well as real-world datasets which were analyzed, the authors ensure a realistic model of the pallet exchange system in Germany.FindingsThe authors demonstrated that, with the help of this platform concept, transport routes can be shortened, debts and receivables can partly be equaled out through balancing, and the quantity of pallets in the overall system can be reduced.Research limitations/implicationsThe results are not directly transferable to pallet exchange systems in other countries without considering their general settings.Practical implicationsDigital networking increases the efficiency of the existing pallet exchange system. Even small collaborations prove to be reasonable.Originality/valueThe authors developed new mechanisms for a digital pallet exchange platform, which takes on the role of a central planning instance, in addition to recording pallet receivables and debts. It enables the planning of the commodity flow of empty pallets, which are transported by the forwarders on regular routes, and distributed between the platform participants.
A multi-tier approach to supply chain collaboration: implications of shopper solutions
Authors: Newman Christopher , Gligor David , Cho Yoon-Na 
Published: October 2022

PurposeThe authors explored the impact of a popular supply chain collaboration initiative – the shopper solution – on both retailers and manufacturers, as well as on the shopper.Design/methodology/approachThe authors conducted a quasi-experimental field study, an experimental online study and an experimental behavioral lab study.FindingsOverall, results revealed that shopper solutions increase the quantity and breadth of displayed products sold, along with sales totals. Shoppers also expressed higher willingness-to-pay (WTP) for products displayed in solutions. Shoppers positively (negatively) attributed the presence (absence) of solutions more strongly to retailers than to manufacturers due to perceived differences in manufacturers' concern for shoppers. Specifically, shoppers expressed higher (lower) word-of-mouth (WOM) and loyalty intentions toward retailers than manufacturers when solutions were (not) provided.Originality/valueThe authors provide a more holistic view of supply chain collaboration by showing how different chain members (retailers vs manufacturers) can experience disparate benefits from collaboration. The authors explain this within the context of shopper solutions by demonstrating that differences in perceived concern for shoppers underlies these effects. Thus, findings suggest that shopper marketing initiatives, such as solutions, are not always “win-win-win” outcomes for retailers, manufacturers and shoppers as intended. Overall, this is the first research to assess the implications of shopper solutions for retailers, manufacturers and shoppers, alike.