bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily intake of Citrus jabara fruit peel powder (Japanese Patent No. 5,323,127) improves allergy-like symptoms: A randomized double-blind parallel-group comparative study
Authors: Azuma Seisho , Murakami Yoshinobu , Taniguchi Masahiko , Baba Kimiye , Mima Toru , Nakamura Kiyoshi 
Published: December 2021

Citrus jabara (CJ) is a rare citrus fruit that used to grow naturally only in the southern part of the Kii Peninsula in Japan. Human intervention studies with oral intake of CJ fruit have shown its anti-allergic effects, but the testing method was a pre-post comparison study. In this study, we conducted a randomized, double-blind, parallel-group interventional study to evaluate the volume-dependent effects of oral intake of CJ fruit peel powder (Japanese Patent No. 5,323,127) on nasal and eye allergy-like symptoms. Ninety healthy adults were allocated to three groups and given test foods containing 1,000, 500, and 0 mg of CJ peel powder, with one packet per day for 4 weeks. After excluding those who dropped out or deviated from the study protocol, 73 were included in the efficacy analysis and 86 in the safety analysis. The high-dose group (1,000 mg/day) was significantly lower than the placebo group in the scores of “nasal and eye symptoms” at week 4, and “blocked nose” at weeks 2 and 4 in the evaluation of question I of Japanese Rhino-conjunctivitis Quality of Life Questionnaire (JRQLQ No. 1). The changes in scores (difference from the pre-observation period) on the Nasal and Eye Symptom Questionnaire showed a dose-dependent reduction in rhinorrhea. In the safety evaluation, there were no significant differences in examinations of physiology, hematology, and blood biochemistry between the groups, and no adverse events attributable to the test foods were observed. These results suggest that intake of CJ peel powder can alleviate allergy-like symptoms.
A fast and effective protocol for obtaining genetically diverse stevia (Stevia rebaudiana Bertoni) regenerants through indirect organogenesis
Authors: Dyduch-Siemińska Magdalena 
Published: December 2021

Plant regeneration through indirect organogenesis allows obtaining genetic variability that can be used in the creation of new cultivars. The study presents a fast and effective protocol of one-step preparation of stevia (Stevia rebaudiana Bertoni) regenerants. To obtain callus tissue and shoot regeneration, leaves and nodal segments were used as primary explants, which were placed on MS (Murashige and Skoog) medium supplemented with plant growth regulators (PGRs): NAA (1-naphthaleneacetic acid – 2.0 mg·dm–3, BA (6-benzylaminopurine – 4.0 mg·dm–3), 2,4‑D (2,4-dichlorophenoxyacetic – 2.0 mg·dm–3). Callus tissue was formed on both types of explants, however, only those derived from nodal segments were proliferating. An average of 3.92 shoots per explant were obtained from leaf explants on the applied medium after 6 weeks of culture. The analysis of the morphogenetic capacity of the obtained regenerants was carried out on MS medium supplemented with PGRs – kinetin (0.25 mg·dm–3), BA (0.5 mg·dm–3). The evaluation of the mean number of shoots, mean shoot length (cm), and the mean number of nodes per shoot indicated phenotypic variability of regenerants. The use of RAPD (randomly amplified polymorphic DNA) markers confirmed the differences also at the DNA level. The proposed one-step indirect organogenesis regeneration protocol induced somaclonal variation of Stevia rebaudiana Bertoni and the obtained regenerants, after selection, could be used in the breeding of this species.
Genetic polymorphism of interleukin-12β (rs7709212) in chronic and aggressive periodontitis in a group of the Bengali population of India
Authors: Das Avishek , Pal Ashit , Bagchi Somen 
Published: December 2021

Objectives:
The genetic basis of periodontitis was demonstrated by formal genetic studies which were focused on a range of various candidate genes selected for their roles in the immune system like genes of the interleukins (IL). Bone proresorptive cytokines such as IL-1 and tumor necrosis factor-α are primarily regulated by a network of other T-cell derived cytokines, including IL-12 family. Specific objective of this study was to find out any association between IL-12β 3΄ untranslated region (UTR) (rs7709212) gene polymorphism and chronic as well as aggressive periodontitis (AgP) in Bengali population of West Bengal, India.

Materials and Methods:
A total of 88 Bengali participants of both sexes were recruited and were divided into three groups: Group A (chronic periodontitis [CP] group), Group B (AgP group), and Group C (healthy control). DNA extraction from collected peripheral venous blood was performed by phenol chloroform method and ethanol precipitation. Genotyping of extracted DNA samples was carried out for locus IL-12β 3΄UTR (rs7709212) by real time-polymerase chain reaction. Association between genotypes and cases was examined by the odds ratio with 95% confidence interval and chi-square analysis using R statistical software. Statistical significance was defined as P < 0.05.

Results:
On analysis of the minor allele frequencies of total periodontitis cases and control, the results were found to be statistically significant with the P = 0.03045.

Conclusion:
The present study suggested a strong association of single nucleotide polymorphism of IL-12β (rs7709212) with total periodontitis cases (both CP and AgP) in the present study cohort.
Identifikasi Senyawa Asam Lemak Volatil dari Air Limbah Industri Minyak Kelapa Sawit untuk Produksi Polihidroksialkanoat oleh Ralstonia eutropha JMP 134
Authors: Aznury Martha , Setiadi Tjandra 
Published: December 2021

Identification of Volatile Fatty Acids from Palm Oil Mill Effluent for Polyhydroxyalkanoate Production by Ralstonia eutropha JMP 134 Abstract Polyhydroxyalkanoate (PHA) is a bioplastic which is derived from bacterial fermentation. In this study, PHA is produced by utilizing Ralstonia eutropha JMP 134 and volatile fatty acids (VFA) from palm oil industrial wastewater as a precursor. The aim of this research is to study the effect of carbon source, addition time, and VFA concentration on PHA production by fermentation using Ralstonia eutropha JMP 134 in batch. PHA and dry cell weight (DCW) concentrations obtained by adding VFA from palm oil industrial wastewater in batches at 20 and 40 hours were 0.014 g/L.hour, 2.76 g/L and 3.66 g/L, respectively. The results also showed that the time of adding VFA greatly affected cell growth, with the best addition time being after the 20th hour. Keywords: palm oil industrial wastewater, polyhydroxyalkanoate (PHA), batch, Ralstonia eutropha JMP 134, volatile fatty acids (VFA) Abstrak Polihidroksialkanoat (PHA) adalah bioplastik yang diproses melalui proses fermentasi dengan mikroba. Pada penelitian ini, PHA diproduksi dengan menggunakan Ralstonia eutropha JMP 134 dan memanfaatkan asam lemak volatil (ALV) dari air limbah industri minyak kelapa sawit sebagai prekursor. Penelitian ditujukan mempelajari pengaruh sumber karbon, waktu penambahan, dan konsentrasi ALV terhadap poduksi PHA yang difermentasi menggunakan Ralstonia eutropha JMP 134 secara batch. Konsentrasi PHA dan berat kering sel (BKS) yang diperoleh pada penambahan ALV dari air limbah industri kelapa sawit secara batch pada jam ke-20 dan 40 masing-masing bernilai 0,014 g/L.jam, 2,76 g/L dan 3,66 g/L. Hasil penelitian memperlihatkan pula bahwa waktu penambahan ALV sangat mempengaruhi pertumbuhan sel, dengan waktu penambahan yang terbaik adalah setelah pada jam ke-20. Kata kunci: air limbah industri minyak kelapa sawit, polihidroksialkanoat (PHA), batch, Ralstonia eutropha JMP 134, asam lemak volatil (ALV)
PROBLEMATIKA DAN DINAMIKA PERBANKAN SYARIAH DI ERA GLOBALISASI
Authors: Nugraha Triyan Putra Zulfadli , Thamrin Husni 
Published: December 2021

Penelitian ini bertujuan untuk menganalisa faktor eksternal dan internal yang mempengaruhi perkembangan perbankan syariah di Indonesia. Dalam membahas problematika dan dinamika perbankan syariah di era globalisasi ini penulis menggunakan jenis dan sumber data yang didapat dari riset perpustakaan (library research) dengan mengadopsi pemikiran dan pendapat para ahli yang memiliki keterkaitan secara langsung atau tidak langsung dengan topik yang sedang dibahas. Perbankan syariah lahir untuk menjadi alternatif bagi masyarakat yang menginginkan bertransaksi dengan sistem syariah, ada beberapa faktor yang menjadi keunggulan bank syariah jika dibandingkan dengan bank konvensional yakni : menyertakan nilai-nilai ketuhanan dalam setiap transaksi, adanya keterikatan emosional secara religi antara bank dan nasabah, adanya keadilan dalam bagi hasil simpanan dan pembiayaan. Akan tetapi disisi lain mereka dihadapkan pada problematika yang membuat mereka sulit untuk berkembang. Faktor keterbatasan kemampuan SDM, minimnya sosialisasi dan edukasi kepada masyarakat, kurangnya pemahaman dan animo umat serta keterbatasan layanan terhadap pelanggan menjadi penghambat bagi bank syariah. Agar tetap eksis dan berkembang, bank syariah harus mampu menerobos dominasi bank konvensional dengan kekuatan korelasi antara pemerintah, institusi pendidikan serta inovasi dari pihak bank syariah itu sendiri. Bank syariah juga dituntut untuk lebih adaptif dan inovatif terhadap kebutuhan pangsa pasar.
Microvascular decompression for trigeminal neuralgia, long-term follow-up results and assessment of possible prognostic factors: a single-center retrospective cross-sectional cohort study
Authors: Naboichenko Andrii G. , Fedirko Volodymyr O. , Yehorov Mykola V. , Lisianyi Oleksandr M. , Onishchenko Petro M. , Tsiurupa Dmytro M. , Shust Vasyl V. , Lisianyi Andrii O. 
Published: December 2021

Aim: Prognostic factors detection and analysis of long-term results of microvascular decompression for trigeminal neuralgia.
Materials and methods. 161 cases of trigeminal neuralgia (TN) treatment by MVD technique without preliminary invasive interventions within 10 years were analyzed. Two blocks of information were designed which included objective case data (8 factors) and patient satisfaction survey (5 questions). Follow-up minimal cut-off was 1 year (median 5.8 years). The primary end point is the proportion of pain free patients and BNI (Barrow Neurological Institute) score at last follow-up. The secondary end point is the assessment of possible risk factors of treatment failure: symptoms duration, decompression type, affected nerve branches, neurovascular conflict visible on MRI, different indications for surgery. Logit-regression analysis was carried out. Significance level was set at p<0,01.
Results. Among the studied factors as predictors for pain recurrence all but one failed to reach significance threshold. Conflict on MRI (p=0,231), involved nerve branches (p=0,340), indications for surgery (p=0,659), number of involved vessels (p=0,834), achieved decompression type (p=0,157), venous compression (p=0,143), gender (p=0,150), affected side (p=0,934) did not reach the significance level. For symptoms duration p=0,0012.
Conclusions. As a result of multifactorial analysis of study results, the only significant prognostic factor for treatment failure (pain recurrence or worsening of obtained result) was symptoms duration at the time of surgery.
IDENTITAS SOSIAL DAN KEARIFAN LOKAL PADA KUMPULAN CERPEN CELURIT HUJAN PANAS KARYA ZAINUL MUTTAQIN [Social Identity and Local Wisdom in The Collection of Short Stories Celurit Hujan Panas By Zainul Muttaqin]
Authors: Wardianto Bayu Suta 
Published: December 2021

Social society and socio-culture cannot be separated from each other. Therefore, literature was born as a product of society and culture. From these literary works, literary teaching materials with social and cultural background can be made. This study explains the social identity and local wisdom contained in the collection of Celurit Hujan Panas short stories by Zainul Muttaqin. In this study, the method used is the quality desriptive method. The data used comes from quotes on a collection of short stories of Celurit Hujan Panas. This research used listening and note-taking techniques. Research data analysis started from presenting the data, reducing the data, and analyzing conclusions. The results of this study show that the social identity contained in the story are namely (1) social structure, (2) social behavior, and (3) ontological definitions. Moreover, the values of local wisdom contained in the story are (1) culture, (2) beliefs, and (3) social values. Sosial masyarakat dan sosial budaya tidak bisa dipisahkan satu sama lain. Karena itulah, sastra lahir sebagai produk dari sosial dan budaya. Dari karya sastra tersebut, dapat dibuat bahan ajar sastra berlatar sosial dan budaya. Penelitian ini menjelaskan tentang identitas sosial dan kearifan lokal yang terkandung dalam kumpulan cerpen Celurit Hujan Panas karya Zainul Muttaqin. Metode yang digunakan dalam penelitian ini yaitu metode deksriptif kualititatif. Data yang digunakan berasal dari kutipan pada kumpulan cerpen Celurit Hujan Panas. Penelitian menggunakan teknik simak dan catat. Analisis data penelitian dimulai dari menyajikan data, mereduksi data, dan kesimpulan analisis. Penelitian ini menunjukkan hasil bahwa identitas sosial yang terkandung yaitu (1) struktur sosial, (2) tingkah laku sosial, dan (3) definisi ontologis. Nilai kearifan lokal yang terkandung adalah (1) nilai budaya, (2) kepercayaan, dan (3) nilai sosial.
Paisagem cultural e políticas públicas do Patrimônio Mundial no Brasil (2012-2019)
Authors: Civale Leonardo , Martins Walkiria Maria Freitas 
Published: December 2021

O conceito de paisagem cultural, historicamente associado Ã ciência geográfica, foi interpretado como uma tipologia do Patrimônio Mundial e incorporado pelo Comitê da UNESCO em 1992. O artigo objetiva a compreensão deste conceito e das tipologias dele derivadas e operadas pela UNESCO, nos dois casos ocorridos no Brasil: “Rio de Janeiro: paisagens cariocas entre o mar e a montanha” e “Conjunto Moderno da Pampulha”. Após a análise dos dossiês de candidatura ao título de Patrimônio Mundial foi possível identificar os usos da memória e as construções narrativas derivados da confluência do conceito de paisagem cultural e das políticas públicas dos campos do patrimônio brasileiro e mundial. O resultado são os discursos que consagraram esses dois sítios brasileiros como paisagens culturais excepcionais, mundialmente reconhecidas.
Entrevista a Milton Santos, una mirada a los 70 (25 años después)
Authors: Almeida Nilo Américo Lima , Oliveira Faria Marcelo 
Published: December 2021

ENTREVISTA A MILTON SANTOS: una mirada a los 70, 25 años después.
Por Marcelo Faria & Nilo Américo Lima.Revisión del idioma español: Juan S. Galvis Motoa (UNILA)PRESENTACIÓN:
Por iniciativa de la publicación AGB INFORMA (encarte especial de la Sección AGB São Paulo - Asociación de Geógrafos Brasileños), fuimos, Marcelo Faria (entonces socio de AGB-SP, geógrafo y profesor, y yo, Nilo Américo R. Lima de Almeida, entonces Socio de AGB-SP, geógrafo e investigador del Laboratorio de Geografía Política y Ordenamiento Territorial Ambiental del Dep. de Geografía / USP), enlistados para la tarea de entrevistar al prof. Milton Santos, con motivo del 70 cumpleaños de este profesor.Hubo, además de la edad representativa, un fuerte contexto de expresión intelectual de Milton Santos asociado a la expresividad del pensamiento geográfico.
Aproximadamente un año y medio antes, Milton Santos había sido galardonado, por unanimidad, con el Premio Vautrin Lud (1994), considerado el “Premio Nobel de Geografía Mundial”, por primera vez otorgado a un intelectual del hemisferio sur. Los Premios internacionales de geografía a intelectuales del hemisferio sur son muy raros.
En 1996, Milton Santos recibiría la mayoría de los títulos de Doctor Honoris Causa de su carrera. Y más tarde, en 1997, también sería galardonado con el 39º Premio Jabuti do Brasil al mejor libro de ciencias humanas con "La naturaleza del espacio: técnica tiempo razón emoción", también publicado en 1996.
La obra de Milton Santos alcanzó una cúspide global al abordar el concepto de espacio geográfico, pero sobre todo como Instancia Social (al igual que las dimensiones de Política, Economía, Cultura y Tiempo). El espacio geográfico encuentra en Milton Santos la definición de “un conjunto inseparable de sistemas de objeto y acción”, y la dimensión humana de la “fuerza del lugar”, al enfrentar la globalización como una fábula y globalización perversa, en la búsqueda de “ una otra globalización ”.
La propuesta de republicar este material viene con la fuerza de esta contextualización, pero también por la gran oportunidad de ponerlo a disposición en español latinoamericano y por la tecnología de digitalización, ya que solo había una rareza de material impreso en 1996. Es importante recordar que no existe más la plataforma periodística llamada AGB-INFORMA.
Ciertamente, el lector encontrará un debate actual y relevante en estas líneas y reflexiones. Para ofrecer al lector una colaboración en el sistema de búsqueda de intereses, Intercalamos , entre las preguntas y las respuestas, los temas tratados en cada bloque de preguntas.
What is the experience of registered nurses in assessing people with severe mental illness for metabolic syndrome?
Authors: Crawford Ruth , Peini Sisilia Finau , Schutz Teramira Christine 
Published: December 2021

Introduction: Metabolic Syndrome is a prevalent condition in New Zealand and worldwide, affecting adult populations, especially those who are in long-term antipsychotic medications for severe mental illness. Registered nurses play a crucial role in improving the health of this population.
Methods: Five registered nurses with at least two years of working experience in the mental health settings participated in this qualitative, exploratory study, underpinned by the Kakala Research Framework. Semi-structured face-to-face interviews with the participants were undertaken to gather research data and thematic analysis was used to find common themes.
Findings: Registered nurses in mental health services are experiencing clinical and professional enablers as well as professional, organisational and systematic barriers in assessing people with severe mental illness for metabolic syndrome.
Conclusion: Skilled registered nurses in mental health services are required to take the responsibility for providing a “one-stop-shop” for people with metabolic syndrome.
Alcohol Advertising in Pacific Islands Countries and Territories: A Scoping Review
Authors: Ikiua Monleigh , Nosa Vili 
Published: December 2021

Introduction: Alcohol has become embedded into the cultural, economic, and social fabric of Pacific Island Countries and Territories (PICT); however, it continues to be a neglected health issue for many PICT. This scoping literature review explores current alcohol advertising policies in each PICT.
Methods: This review utilises the 'Preferred Reporting Items for Systematic Review and Meta-Analyses for Scoping reviews' to identify literature on alcohol advertising policies. Twenty-five sources, ranging from 1963 to 2020, form the final data synthesis.
Findings: The results of this review reveal that not all PICT have alcohol advertising restrictions in place. Health warning labels as a means of deterring alcohol use are also inconsistent across PICT but aid in consumer decisions. A notable concern in alcohol advertising is the use of culture as a marketing ploy.
Conclusion: This review provides essential information on alcohol advertising in PICT. Nine PICT enforce some form of alcohol advertising prohibition, and ten do not. In countries with alcohol advertising, drinking behaviours vary, demonstrating a need for further research on the implementation efforts of current policies. In countries with no alcohol advertising, alcohol use is normalised and portrayed as unproblematic. The use of health warning labels is also not consistent amongst PICT. The use of culture as a marketing ploy is unacceptable as it belittles culture and is disrespectful to leaders. Understanding the alcohol advertising restrictions that work in each PICT can help decrease alcohol consumption and the harms associated with its misuse across all PICT.
Keywords: Alcohol, Advertising, Pacific.
ISOLATION OF LIVE CELLS FROM DIFFERENT MICE TISSUES UP TO NINE DAYS AFTER DEATH
Authors: Majdič Gregor , Voga Metka , Pleterski Ana 
Published: December 2021

Some limited reports suggest that cells can survive in the cadavers for much longer than it was previously thought. In our study we explored how time after death, tissue type (muscle, brain and adipose tissue), storage temperature of cadavers (4 °C or at room temperature) and form of tissue storage (stored as cadavers or tissue pieces in phosphate buffered saline) affect the success of harvesting live cells from mice after death. Cells were isolated from dead tissues and grown in standard conditions. Some cells were used for RNA extraction and RT² Profiler™ PCR Array for cell lineage identification was performed to establish which lineages the cells obtained from post mortem tissues belong to. Results of our study showed that viable cells can be regularly isolated from muscle and brain tissue 3 days post mortem and with difficulty up to 6 days post mortem. Viable cells from brain tissue can be isolated up to 9 days post mortem. No cells were isolated from adipose tissue except immediately after death. In all instances viable cells were isolated only when tissues were stored at 4 °C. Tissue storage did not affect cell isolation. Isolated cells were progenitors from different germ layers. Our results show that live cells could be obtained from mouse cadavers several days after death.

IZOLACIJA ŽIVIH CELIC IZ RAZLIČNIH TKIV MIŠI DO DEVET DNI PO SMRTI
Izvleček: Nekatere raziskave kažejo, da je preživetje celic v truplih precej daljše, kot je bilo znano do sedaj. V naši raziskavi smo proučevali, kako na uspešnost izolacije živih celic po smrti miši vplivajo različen čas izolacije po smrti, vrsta tkiva (mišično, možgansko in maščobno), temperatura shranjevanja trupel ter oblika shranjenega tkiva (kot koščki tkiv ali kot celi kadavri). Izolacija in gojenje celic iz tkiv mrtvih miši sta potekali pod standardnimi pogoji. Da bi ugotovili, katerim celičnim linijam pripadajo izolirane celice, je bil del celic uporabljen za izolacijo RNK in nadaljno uporabo v sistemu identifikacije izvornih celičnih linij z verižno reakcijo s polimerazo v realnem času. Rezultati naše raziskave so pokazali, da je žive celice mogoče izolirati iz mišičnega in možganskega tkiva 3 dni po smrti, pogojno tudi do 6 dni po smrti. Iz možganskega tkiva je bilo žive celice mogoče izolirati tudi do 9 dni po smrti. Iz maščobnega tkiva je bilo celice mogoče izolirati zgolj takoj po smrti, ne pa tudi v kasnejših časovnih intervalih. V vseh primerih so bile celice izolirane samo v primeru shranjevanja tkiv pri 4°C. Oblika shranjenega tkiva na izolacijo celic ni vplivala. Izolirane celice so pripadale različnim zarodnim plastem. Rezultati raziskave so pokazali, da je žive celice iz mišjih trupel mogoče izolirati tudi več dni po smrti.
Ključne besede: miš; truplo; matične celice; možgansko tkivo; mišično tkivo; maščobno tkivo