bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community engagement, greening, and violent crime: A test of the greening hypothesis and Busy Streets
Authors: Gong Catherine H. , Bushman Gregory , Hohl Bernadette C. , Kondo Michelle C. , Carter Patrick M. , Cunningham Rebecca M. , Rupp Laney A. , Grodzinski Alison , Branas Charles C. , Vagi Kevin J. , Zimmerman Marc A. 
Published: October 2022

AbstractResearchers have documented that vacant lot greening can reduce community‐level crime and violence. Busy Streets Theory (BST) suggests that residents who are involved in the greening process can help to improve physical environments and build social connections that deter crime and violence. Yet few researchers have explored how community engagement in the greening process may affect crime and violence outcomes. We applied BST to test the effects of community‐engaged vacant lot greening compared to vacant lots that received either professional mowing or no treatment, on the density of violent crime around study lots. Using mixed effects regression models, we analyzed trends in violent crime density over the summer months from 2016 to 2018 at 2102 street segments in Youngstown, OH. These street segments fell within 150 meters of an intervention parcel that was classified as one of three conditions: community‐engaged maintenance, professional mowing, or no treatment (control). We found that street segments in areas receiving community‐engaged maintenance or professional mowing experienced greater declines in violent crime density than street segments in areas receiving no treatment, and more decline occurred in the community‐engaged condition compared to the professional mow condition. Our findings support BST and suggest that community‐engaged greening of vacant lots in postindustrial cities with a concentrated vacancy can reduce crime and violence.
Substrate Induced Movement of the Metal Cofactor between Active and Resting State
Authors: Marsden Stefan R. , Wijma Hein J. , Mohr Michael K. F. , Justo Inês , Hagedoorn Peter‐Leon , Laustsen Jesper , Jeffries Cy M. , Svergun Dmitri , Mestrom Luuk , McMillan Duncan G. G. , Bento Isabel , Hanefeld Ulf 
Published: October 2022

AbstractRegulation of enzyme activity is vital for living organisms. In metalloenzymes, far‐reaching rearrangements of the protein scaffold are generally required to tune the metal cofactor's properties by allosteric regulation. Here structural analysis of hydroxyketoacid aldolase from Sphingomonas wittichii RW1 (SwHKA) revealed a dynamic movement of the metal cofactor between two coordination spheres without protein scaffold rearrangements. In its resting state configuration (M2+R), the metal constitutes an integral part of the dimer interface within the overall hexameric assembly, but sterical constraints do not allow for substrate binding. Conversely, a second coordination sphere constitutes the catalytically active state (M2+A) at 2.4 Å distance. Bidentate coordination of a ketoacid substrate to M2+A affords the overall lowest energy complex, which drives the transition from M2+R to M2+A. While not described earlier, this type of regulation may be widespread and largely overlooked due to low occupancy of some of its states in protein crystal structures.
Oxidative stability of high oleic palm and hazelnut skin oil blends
Authors: Akpinar Merve , Bauer Estrada Katherine , Tekin Aziz , Quintanilla‐Carvajal Maria Ximena , Gumus‐Bonacina Cansu Ekin 
Published: October 2022

AbstractHigh oleic palm oil (HOPO) with high oleic and palmitic acid contents is a new vegetable oil that needs to find further use in food applications, while hazelnut skin oil (HSO) with high oleic acid content is a by‐product of hazelnut oil production and have no commercial value. The aim of the study was to obtain new oil blends for new food formulations with high oxidative stability and low (or reasonable) saturated fatty acid content using HOPO and HSO. For this aim, they were blended in the proportions of 0 to 100% (wt/wt), and fatty acid and tocol compositions, induction period and storage stability of the blends were evaluated. Tocotrienols (560.94 mg/kg) constitute the majority of the tocol content of HOPO, while tocopherols (437.69 mg/kg) were the major tocols of HSO. HOPO has a higher saturated fatty acid composition and lower monounsaturated fatty acids content than HSO. In general, it was determined that increasing the HSO ratio in oil blends reduced their oxidative stabilities, which is most likely because HSO is richer in total unsaturated fatty acids (91.8%) than HOPO (68.4%). In addition, tocotrienols are known to be stronger antioxidants than tocopherols. Although HOPO is rich in γ‐tocotrienol, which has a strong antioxidant activity, it also has some disadvantages such as having a high price and containing significant levels of saturated fatty acids (mainly palmitic acid). The optimum blend ratio was then determined as 50% HOPO:50% HSO considering oxidative stability and fatty acid compositions.
Additional evidence for the vascular disruption defect hypothesis in a novel case of brainstem disconnection syndrome
Authors: Vekemans Marie‐Aricie , Maurice Paul , Lachtar Mohamed , Blondiaux Eléonore , Jouannic Jean‐Marie , Burglen Lydie , Rodriguez Diana , Garel Catherine , Valence Stéphanie 
Published: October 2022

AbstractIntroductionBrainstem disconnection syndrome is a rare and severe disease resulting from a midbrain–hindbrain segmental defect. Clinical signs include a severe neurological impairment, an early death (usually during the first year of life), and pathognomonic postnatal brain imaging features. Two major hypotheses are proposed to explain the etiopathogenesis of this syndrome, namely an inborn error of morphogenesis or a vascular disruption defect.Case Report and Literature ReviewHere we report on prenatal (ultrasound; fetal MRI) and postnatal (MRI) neuroimaging findings observed in a full‐term female newborn with a brainstem disconnection syndrome. The prenatal and postnatal findings point toward an early fetal vascular disruption defect as the pregnancy was marked by three episodes of hospitalization resulting from a very severe maternal dehydration. The first episode took place as early as the 18th week of gestation. Our clinical follow‐up at 1 year age is well in line with the findings observed in 13 other cases reported in the literature. Interestingly, among these 13 cases, a vascular disruption defect was suggested in 8 patients and confirmed by autopsy in at least 2 cases.ConclusionIn the present report, we bring objective evidence for the antenatal cause of a brainstem disconnection syndrome resulting from a vascular disruption defect occurring in the context of a severe maternal dehydration. In particular, our neuroimaging findings observed during pregnancy and after birth illustrate the prenatal occurrence of this vascular disruption defect.
Recent Developments with Icetexane Natural Products
Authors: Naeini Ali Amiri , Ziegelmeier Alexandre A. , Chain William J. 
Published: October 2022

AbstractIcetexane diterpenoids are a diverse family of natural products sourced from several species of terrestrial plants. Icetexanes exhibit a broad array of biological activities and together with their complex 6‐7‐6 tricyclic scaffolds, they have piqued the interest of synthetic organic chemists, natural products chemists, and biological investigators over the past four decades and were reviewed 13 years ago. This review summarizes icetexane natural products isolated since 2009, provides an overview of new synthetic approaches to the icetexane problem, and proposes an additional classification of icetexanes based on novel structures that are unlike previously isolated materials.
Protective role of the dandelion extract against the blood–liver axis, cell membranes, and anemia disorder in sodium benzoate‐exposed rats
Authors: Suljević Damir , Mitrašinović‐Brulić Maja , Dervišević Amela , Fočak Muhamed 
Published: October 2022

AbstractSodium benzoate (SB) as an additive in various food products prevents the growth of microbes. Although SB is considered safe, many studies have reported adverse effects. The aim of this study was to investigate the effect of dandelion extract on cell damage and hematological and biochemical disorders induced by SB in male albino rats. Different doses of SB (200 and 600 mg/kg) and ethanolic dandelion root extract (D) (40 mg/kg) were used in a 2‐week treatment of rats. Rat mortality and a higher frequency of behavioral alterations such as apathy, anxiety, and aggression have been reported at a higher dose of SB. Changes in urine pH, proteinuria, nitrituria, and bilirubinemia caused by SB were regulated by adding dandelion extract. Analysis of specific serum and urine parameters, as well as microscopic analysis of hepatocytes, showed liver and kidney failure. Anemia associated with hemolytic disorder due to erythrocyte impaired the presence of acanthocytes, and decreased values of erythrocyte blood count, hemoglobin concentration, average red blood cell size, hemoglobin amount per red blood cell, and mean corpuscular hemoglobin concentration were caused by SB treatment. As a dietary supplement, dandelion extract can be useful in the prevention of SB‐induced liver and kidney injury, and also a remedy against induced anemia, neutropenia, thrombocytopenia, hyperproteinemia, hyperglycemia, and reduction of inflammatory responses.
Plant‐based Basic Carbocatalyst for Lactone Ring‐Opening Polymerization and Isosorbide Transesterification with High Efficiency
Authors: Al‐Naji Majd , Brandi Francesco , Kumru Baris , Antonietti Markus 
Published: October 2022

AbstractBasic carbocatalyst made of simple natural precursors using environmentally friendly processes are eagerly required for a wide range of chemical processes. This work is devoted to a carbocatalyst with base functionality from soybean flour as a nitrogen‐rich carbon source. This metal‐free basic carbocatalyst showed a density of basic sites of 0.165 mmol g−1as quantified via CO2‐TPD. The activity of the prepared basic carbons was successfully confirmed in two industrially important base‐catalyzed reactions of green chemistry, namely, ring‐opening polymerization (ROP) of ϵ‐caprolactone and transesterification of isosorbide with dimethyl carbonate. Utilizing the prepared basic carbon in the ROP reaction of ϵ‐caprolactone, gave a white polymer with high molecular weight (Mw=30000 g mol−1), which is comparable to industrial products. Moreover, a yield of 79 % of isosorbide bismethyl carbonate was obtained using the prepared basic carbon in isosorbide transesterification with dimethyl carbonate at 493 K for 6 hours.
Constructing Netlike Nanosheets of ZnO/BiOCl with Heterojunction as Robust Material for Electrochemical Amine Detection
Authors: Ahmed Maruf , Zhao Ruihua , Xing Tian , Du Jianping 
Published: October 2022

AbstractThe electrochemical sensing is a potential method for detection of trace toxic substance. Herein, the heterojunction of netlike ZnO/BiOCl nanosheets was constructed for the enhanced electrochemical detection of ammonia. Cyclic voltammetry and linear sweep voltammetry were used to investigate the electrochemical performance. The results show that the ZnO/BiOCl‐modified electrode exhibits higher sensitivity towards ammonia compared with the ZnO and BiOCl‐based electrodes, which is ascribed to band structure and fast electron transfer. The high response of 11.8 μA mM−1 and a low detection limit (LOD) of 0.25 μM are achieved. In addition, the ZnO/BiOCl material exhibits high selectivity, repeatability and stability. The better linear relationship between concentration and current (R2=0.99) is significant for quantitative detection of ammonia, implying that netlike ZnO/BiOCl nanosheets can serve as electrochemical sensing platform for detecting toxic substance. This research provides a strategy for fabricating two‐dimensional netlike materials and regulating heterojunctions used for electrochemical application.
A Thermally Activated Delayed Fluorescence Emitter Investigated by Time‐Resolved Near‐Infrared Spectroscopy
Authors: Haselbach Wiebke , Kaminski Jeremy M. , Kloeters Laura N. , Müller Thomas J. J. , Weingart Oliver , Marian Christel M. , Gilch Peter , Nogueira de Faria Barbara E. 
Published: October 2022

AbstractEmitters for organic light‐emitting diodes (OLEDs) based on thermally activated delayed fluorescence (TADF) require small singlet (S1)‐triplet (T1) energy gaps as well as fast intersystem crossing (ISC) transitions. These transitions can be mediated by vibronic mixing with higher excited states Snand Tn(n=2, 3, 4, …). For a prototypical TADF emitter consisting of a triarylamine and a dicyanobenzene moiety (TAA‐DCN) it is shown that these higher states can be located energetically by time‐resolved near‐infrared (NIR) spectroscopy.
Tannery Effluents: Current Practices, Environmental Consequences, Human Health Risks, and Treatment Options
Authors: Singh Kavita , Kumari Madhu , Prasad Kumar Suranjit 
Published: October 2022

AbstractThe tannery industry influences the gross domestic product/economic activity of any country, but the uncontrolled release of tannery effluents causes environmental degradation and increases health risks to human. The reason for the toxicity of tannery effluents is the presence of high concentrations of organic and inorganic chemicals used in the production of leather goods. Untreated or partially treated effluents discharged into surface water results in an increase in both chemical and biological oxygen demand as well as in an increase in the levels of total suspended solids, dissolved solids, and toxic metals in environmental bodies, especially in soil, water bodies, and water sediments. Various treatment techniques, such as physicochemical, biological, and advanced oxidation methods, which include chemical precipitation, electrocoagulation, aerobic or anaerobic treatment, wetland construction, and Fenton, electro‐Fenton, and photo‐Fenton processes are also described. This review also discusses the technical appropriateness and economic feasibility of reducing the effluent pollution load and solid waste emanating from the tannery industry. Considering the enhanced health risks in the tannery waste treatment and management regime, some green and advanced technologies should be explored. A sustainable green technology that avoids the use of toxic chemicals in the tanning process is seen well for ecological health.
Incidence, characteristics, and management of central nervous system metastases in patients with inflammatory breast cancer
Authors: Warren Laura E.G. , Niman Samuel M. , Remolano Marie C. , Landry Jean M. , Nakhlis Faina , Bellon Jennifer R. , Aizer Ayal A. , Lin Nancy U. , Tolaney Sara M. , Regan Meredith M. , Overmoyer Beth A. , Lynce Filipa 
Published: October 2022

BackgroundPatients with inflammatory breast cancer (IBC) have a high risk of central nervous system metastasis (mCNS). The purpose of this study was to quantify the incidence of and identify risk factors for mCNS in patients with IBC.MethodsThe authors retrospectively reviewed patients diagnosed with IBC between 1997 and 2019. mCNS‐free survival time was defined as the date from the diagnosis of IBC to the date of diagnosis of mCNS or the date of death, whichever occurred first. A competing risks hazard model was used to evaluate risk factors for mCNS.ResultsA total of 531 patients were identified; 372 patients with stage III and 159 patients with de novo stage IV disease. During the study, there were a total of 124 patients who had mCNS. The 1‐, 2‐, and 5‐year incidence of mCNS was 5%, 9%, and 18% in stage III patients (median follow‐up: 5.6 years) and 17%, 30%, and 42% in stage IV patients (1.8 years). Multivariate analysis identified triple‐negative tumor subtype as a significant risk factor for mCNS for stage III patients. For patients diagnosed with metastatic disease, visceral metastasis as first metastatic site, triple‐negative subtype, and younger age at diagnosis of metastases were risk factors for mCNS.ConclusionsPatients with IBC, particularly those with triple‐negative IBC, visceral metastasis, and those at a younger age at diagnosis of metastatic disease, are at significant risk of developing mCNS. Further investigation into prevention of mCNS and whether early detection of mCNS is associated with improved IBC patient outcomes is warranted.
Dynamic modulations of sphingolipids and glycerophospholipids in COVID‐19
Authors: Kurano Makoto , Okamoto Koh , Jubishi Daisuke , Hashimoto Hideki , Sakai Eri , Saigusa Daisuke , Kano Kuniyuki , Aoki Junken , Harada Sohei , Okugawa Shu , Doi Kent , Moriya Kyoji , Yatomi Yutaka 
Published: October 2022

AbstractBackgroundA heterogeneous clinical phenotype is a characteristic of coronavirus disease 2019 (COVID‐19). Therefore, investigating biomarkers associated with disease severity is important for understanding the mechanisms responsible for this heterogeneity and for developing novel agents to prevent critical conditions. This study aimed to elucidate the modulations of sphingolipids and glycerophospholipids, which have been shown to possess potent biological properties.MethodsWe measured the serum sphingolipid and glycerophospholipid levels in a total of 887 samples from 215 COVID‐19 subjects, plus 115 control subjects without infectious diseases and 109 subjects with infectious diseases other than COVID‐19.ResultsWe observed the dynamic modulations of sphingolipids and glycerophospholipids in the serum of COVID‐19 subjects, depending on the time course and severity. The elevation of C16:0 ceramide and lysophosphatidylinositol and decreases in C18:1 ceramide, dihydrosphingosine, lysophosphatidylglycerol, phosphatidylglycerol and phosphatidylinositol were specific to COVID‐19. Regarding the association with maximum severity, phosphatidylinositol and phosphatidylcholine species with long unsaturated acyl chains were negatively associated, while lysophosphatidylethanolamine and phosphatidylethanolamine were positively associated with maximum severity during the early phase. Lysophosphatidylcholine and phosphatidylcholine had strong negative correlations with CRP, while phosphatidylethanolamine had strong positive ones. C16:0 ceramide, lysophosphatidylcholine, phosphatidylcholine and phosphatidylethanolamine species with long unsaturated acyl chains had negative correlations with D‐dimer, while phosphatidylethanolamine species with short acyl chains and phosphatidylinositol had positive ones. Several species of phosphatidylcholine, phosphatidylethanolamine and sphingomyelin might serve as better biomarkers for predicting severe COVID‐19 during the early phase than CRP and D‐dimer. Compared with the lipid modulations seen in mice treated with lipopolysaccharide, tissue factor, or histone, the lipid modulations observed in severe COVID‐19 were most akin to those in mice administered lipopolysaccharide.ConclusionA better understanding of the disturbances in sphingolipids and glycerophospholipids observed in this study will prompt further investigation to develop laboratory testing for predicting maximum severity and/or novel agents to suppress the aggravation of COVID‐19.
Early versus delayed interventions for necrotizing pancreatitis: A systematic review and meta‐analysis
Authors: Nakai Yousuke , Shiomi Hideyuki , Hamada Tsuyoshi , Ota Shogo , Takenaka Mamoru , Iwashita Takuji , Sato Tatsuya , Saito Tomotaka , Masuda Atsuhiro , Matsubara Saburo , Iwata Keisuke , Mukai Tsuyoshi , Isayama Hiroyuki , Yasuda Ichiro 
Published: October 2022

AbstractObjectivesInterventions for necrotizing pancreatitis are generally postponed until 4 weeks after the onset of acute pancreatitis, but there remains controversy about whether we should always wait >4 weeks or can intervene early when necessary. This meta‐analysis was conducted to evaluate treatment outcomes of necrotizing pancreatitis according to the cut‐off defined in the revised Atlanta classification (≤4 vs. >4 weeks).MethodsUsing PubMed, Web of Science, and the Cochrane database, we identified clinical studies published until March 2022 with data comparing outcomes of early and delayed interventions of necrotizing pancreatitis. We pooled data on adverse events, mortality, technical and clinical success rates, and needs for necrosectomy and open surgery, using the random‐effects model.ResultsWe identified 11 retrospective studies, including 775 patients with early interventions and 725 patients with delayed interventions. Patients with early interventions tended to be complicated by organ failure. The rate of adverse events was comparable (OR 1.41, 95% CI 0.66–3.01; p = 0.38) but the rate of mortality was significantly higher (OR 1.70, 95% CI 1.21–2.40; p < 0.01) in early interventions. Technical success rates were similarly high but clinical success rates tended to be low (OR 0.39, 95% CI 0.15–1.00; p = 0.05) in early interventions, though not statistically significant. Pooled ORs for necrosectomy and open surgery were 2.14 and 1.23, respectively.ConclusionsEarly interventions for necrotizing pancreatitis were associated with higher mortality rates and did not reduce adverse events or improve clinical success. However, our results should be confirmed in prospective studies.
Small mammals from the Caatinga: A dataset for the Brazilian semiarid biome
Authors: da Costa‐Pinto Anna Ludmilla , Bovendorp Ricardo S. , Bocchiglieri Adriana , Caccavo Aldo , Delciellos Ana Cláudia , Malhado Ana Cláudia , de Almeida Ana Karolina Rodrigues , Braga Caryne , Loretto Diogo , Câmara Edeltrudes Maria Valadares Calaça , Menezes Fernando Heberson , Guilhon Gabby , Paise Gabriela , Sobral Gisela , Varjão Iardley Cícero Gomes , Ferreira Jéssica Viviane Amorim , da Silva Oliveira Leandro , Geise Lena , Pereira Luiz Cezar Machado , Corrêa Matheus Rocha Jorge , Nicola Patricia Avello , Guedes Patricia Gonçalves , Becker Rafael Gustavo , Barreto Rebeca Mascarenhas Fonseca , da Silva Shirley Seixas Pereira , Orsini Vinicius Santana , Ladle Richard James 
Published: October 2022

AbstractThe Caatinga is an exclusively Brazilian biome, and is the largest and most biodiverse Seasonal Tropical Dry Forest in the world. Despite that, the mammalian fauna, especially small mammals, is the least studied of all Brazilian biomes. In order to fill gaps and provide detailed information on small mammals (Didelphimorphia, Rodentia) in the Caatinga biome, we compiled reliable records focusing on richness, composition and some biometric data. These records came from mammal collections, papers, theses, books, and unpublished data, prioritizing records with vouchers housed in scientific collections. We compiled a total of 3133 records from 816 locations, resulting in a richness of 47 native species (12 marsupials and 35 rodents, plus three exotic rodents, Rattus rattus, Rattus norvegicus, and Mus musculus). This dataset includes records of three new species for the biome and its transition zone: the rodents Calomys mattevii, Holochilus oxe, and Nectomys squamipes. Of the total number of records, 1808 (57.71%) are from consulting activities, 95 (3.03%) are from zoonoses studies and 104 (3.32%) are from the National Plague Service (SNP). All nine Brazilian states with territory in the Caatinga have sampling data for small mammals, but the number of records and localities are unevenly distributed, with the state of Rio Grande do Norte having the lowest number of records and locations sampled. Our dataset is the first of its kind for the Caatinga biome and has considerable potential value for studies of habitat use, landscape ecology, macroecology, biogeography, and conservation. There are no copyright restrictions on the data. Please cite this data paper when the data are used in publications. We also request that researchers and teachers inform us of how they are using the data.