bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbe-assisted crop improvement: a sustainable weapon to restore holobiont functionality and resilience
Authors: Marco Sandrini , Loredana Moffa , Riccardo Velasco , Raffaella Balestrini , Walter Chitarra , Luca Nerva 
Published: July 2022

AbstractIn the past years, breeding programs have been mainly addressed on pushing the commercial features, forgetting important traits, such as those related to environmental stress resilience, that are instead present in wild relatives. Among the traits neglected by breeding processes, the ability to recruit beneficial microorganisms that recently is receiving a growing attention due to its potentiality. In this context, this review will provide a spotlight on critical issues of the anthropocentric point of view that, until now, has characterized the selection of elite plant genotypes. Its effects on the plant-microbiome interactions, and the possibility to develop novel strategies mediated by the exploitation of beneficial root-microbe interactions, will be discussed. More sustainable microbial-assisted strategies might in fact foster the green revolution and the achievement of a more sustainable agriculture in a climatic change scenario.
HsfA1a confers pollen thermotolerance through upregulating antioxidant capacity, protein repair, and degradation in Solanum lycopersicum L.
Authors: Xie Dong-Ling , Huang Hua-Min , Zhou Can-Yu , Liu Chen-Xu , Kanwar Mukesh Kumar , Qi Zhen-Yu , Zhou Jie 
Published: July 2022

Abstract
The heat shock transcription factors (Hsfs) play critical roles in plant responses to abiotic stresses. However, the mechanism of Hsfs in the regulation of pollen thermotolerance and their specific biological functions and signaling remain unclear. Herein, we demonstrate that HsfA1a played a key role in tomato pollen thermotolerance. Pollen thermotolerance was reduced in hsfA1a mutants but was increased by hsfA1a overexpression, based on pollen viability and germination. Analyzing the whole transcriptome by RNA-seq data, we found that HsfA1a mainly regulated the genes involved in oxidative stress protection, protein homeostasis regulation and protein modification, as well as the response to biological stress in anthers under heat stress. The accumulation of reactive oxygen species in anthers was enhanced in hsfA1a mutants but decreased in HsfA1a-overexpressing lines. Furthermore, HsfA1a bound to the promoter region of genes involved in redox regulation (Cu/Zn-SOD, GST8, and MDAR1), protein repair (HSP17.6A, HSP70-2, HSP90-2, and HSP101) and degradation (UBP5, UBP18, RPN10a, and ATG10) and regulated the expression of these genes in tomato anthers under heat stress. Our findings suggest that HsfA1a maintains pollen thermotolerance and cellular homeostasis by enhancing antioxidant capacity and protein repair and degradation, ultimately improving pollen viability and fertility.
Environmental and anthropogenic driven transitions in the demersal ecosystem of Cantabrian Sea
Authors: Polo J , Punzón A , Vasilakopoulos P , Somavilla R , Hidalgo M 
Published: July 2022

Abstract
In the framework of global human-induced change, marine communities’ often respond to changing conditions abruptly reorganizing into new equilibria. These shifts are difficult to predict and often imply irreversible adjustments due to hysteresis. Unraveling the role of the forces leading regime shifts is a major challenge. We explored the temporal evolution of 63 fish species representing the Cantabrian bentho-demersal community in response to environmental changes and fishing pressure in the period 1983–2018, using survey data. Via multivariate analysis and non-additive modeling of a community index and the system's main stressors, two decadal-scale regimes were revealed, suggesting a non-linear response of the community to its environment. The Integrated Resilience Assessment framework elucidated the response mechanism to the candidate stressors and allowed quantifying resilience dynamics. The decline in fishing pressure in the 1990s was associated with a gradual transition of the system, while further decline during the 2000s eroded the resilience of the system towards changes in its stressors, leading to a discontinuous response expressed as an abrupt, possibly irreversible shift in the 2010s. Given the teleconnected character of marine ecosystems, this regional study endorses the scientific effort for actions facing the dynamic impacts of climate change on exploited marine ecosystems.
How Effective Is Private Dispute Resolution? Evidence From Ireland
Authors: Roche William K 
Published: July 2022

Abstract
This article examines the effectiveness of private dispute resolution arrangements (PDRAs) established voluntarily by employers and unions in private- and public-sector firms and agencies in Ireland. PDRAs comprise three-person panels or sole adjudicators and combine binding or non-binding adjudication with internal mediation. PDRAs seek to rewrite the established rules and conventions governing dispute resolution within workplaces and to change the ways in which internal dispute resolution is aligned with external dispute resolution by state agencies. The majority of the eleven PDRAs examined are shown to be effective. One is described as ‘semi-dormant’ and two are shown to be less effective. Variations in the effectiveness of PDRAs are attributed to features of the internal and external contexts of the firms and agencies in which they have been established: the persistence of significant commercial and industrial relations challenges; the absence of disjunctures in organisations or industrial relations; the presence of champions; and the effects of industrial relations legacies. The paper contributes to the literature by systematically accounting for variations in the effectiveness of adjudication and arbitrations arrangements and concludes by considering whether the incidence of PDRAs is likely to continue rising.
Current clinical practice in antibiotic treatment of Staphylococcus aureus bacteraemia: results from a survey in five European countries
Authors: Buis D T P , Prins J M , Betica-Radic L , de Boer M G J , Ekkelenkamp M , Kofteridis D , Peiffer-Smadja N , Schouten J , Spernovasilis N , Tattevin P , ten Oever J , Sigaloff K C E 
Published: July 2022

Abstract

Objectives
To determine clinical practice variation and identify knowledge gaps in antibiotic treatment of Staphylococcus aureus bacteraemia (SAB).

Methods
A web-based survey with questions addressing antibiotic treatment of SAB was distributed through the ESGAP network among infectious disease specialists, clinical microbiologists and internists in Croatia, France, Greece, the Netherlands and the UK between July 2021 and November 2021.

Results
A total number of 1687 respondents opened the survey link, of whom 677 (40%) answered at least one question. For MSSA and MRSA bacteraemia, 98% and 94% preferred initial monotherapy, respectively. In patients with SAB and non-removable infected prosthetic material, between 80% and 90% would use rifampicin as part of the treatment. For bone and joint infections, 65%–77% of respondents would consider oral step-down therapy, but for endovascular infections only 12%–32% would. Respondents recommended widely varying treatment durations for SAB with different foci of infection. Overall, 48% stated they used 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG-PET/CT) to guide antibiotic treatment duration. Persistent bacteraemia was the only risk factor for complicated SAB that would prompt a majority to extend treatment from 2 to 4–6 weeks.

Conclusions
This survey in five European countries shows considerable clinical practice variation between and within countries in the antibiotic management of SAB, in particular regarding oral step-down therapy, choice of oral antibiotic agents, treatment duration and use of 18F-FDG-PET/CT. Physicians use varying criteria for treatment decisions, as evidence from clinical trials is often lacking. These areas of practice variation could be used to prioritize future studies for further improvement of SAB care.
Optimization of antimicrobial dosing in patients with acute kidney injury: a single-centre observational study
Authors: Hughes Stephen , Heard Katie L , Mughal Nabeela , Moore Luke S P 
Published: July 2022

Abstract

Background
Acute kidney injury (AKI) is a potential complication of systemic infection. Optimizing antimicrobial dosing in this dynamic state can be challenging with sub- or supra-therapeutic dosing risking treatment failure or toxicity, respectively. Locally, unadjusted renal dosing for the first 48 h of infection is recommended.

Objectives
To determine the outcomes associated with this dosing strategy.

Methods
A retrospective cohort analysis was undertaken in patients treated for Gram-negative bacteraemia with concurrent non-filtration dependent AKI from a single-centre NHS acute hospital (April 2016–March 2020). Patient demographics, microbiology data, antimicrobial treatment and patient outcome (in-hospital mortality and kidney function) were analysed.

Results
In total, 647 episodes of Gram-negative bacteraemia (608 patients) were included; 305/608 (50.2%) were male with median age 71 years (range 18–100). AKI was present in 235/647 (36.3%); 78/647 (12.1%) and 45/647 (7.0%) having Kidney Disease Improving Global Outcomes-defined injury (stage 2) or failure (stage 3), respectively. In-hospital 30 day mortality was 25/352 (7.1%), 14/112 (12.5%), 26/123 (21.1%) and 11/60(18.3%) in patients with normal renal function, AKI stage 1, AKI stage ≥2 and established chronic kidney disease, respectively. Recovery of renal function at Day 21 or discharge was present in 105/106 surviving patients presenting with AKI stage ≥2. Time to recovery of AKI was similar in patients receiving full, low or no aminoglycoside (3 versus 4 versus 3 days, P = 0.612) and those receiving full- and low-dose β-lactam (3 versus 5 days, P = 0.077).

Conclusions
There is a high burden of AKI in patients with Gram-negative bacteraemia. Dose adjustments of β-lactams may not be necessary in the first 48 h of infection-induced AKI and single-dose aminoglycosides may be considered for early empirical coverage.
Automation of crane control for block lifting based on deep reinforcement learning
Authors: Chun Do-Hyun , Roh Myung-Il , Lee Hye-Won 
Published: July 2022

Abstract
In shipyards, blocks are controlled by connecting the crane and block with wires during block erection. During block lifting, if a block is not carefully controlled, it will cause damage. Block lifting using crane operation is performed by controlling the number of wires, hooks, and equalizers. Consequently, predicting stable block lifting is difficult. In this study, we proposed a control method to determine static equilibrium. Initially, an algorithm for finding the initial equilibrium state of the block (IES algorithm) was proposed, followed by deep reinforcement learning (DRL)-based method for block lifting. The position, orientation, angular velocity of the block, and hoisting speed of the wires were applied as the DRL state. The control input of the crane was calculated by deriving the hoisting speed of the wires. To verify the proposed method, comparative studies on the application of the IES algorithm were carried out, and further block movement was compared. Conclusively, the proposed method effectively increased block lifting safety.
The Complexities of Comparative Climate Constitutionalism
Authors: Ghaleigh Navraj Singh , Setzer Joana , Welikala Asanga 
Published: July 2022

Abstract
Climate constitutionalism is a relatively novel legal field that has nonetheless adopted a very distinct character. Picking up on the classical liberal tack, it is marked by a distrust of state power as it relates to climate action or inaction. This is a venerable approach. In his 1967 classic, MJC Vile recounts that the ‘great theme of the advocates of constitutionalism [had been] the frank acknowledgement of the role of government in society, linked with the determination to bring that government under control and to place limits on the exercise of its power’. This mode of distrust has been ported to the climate constitutionalism literature and in particular its focus on adjudication of constitutional rights provisions for climate purposes. This, we argue, is but one aspect of climate constitutionalism that no longer speaks to the needs of the world when we think about the relationship between climate change, the doctrines and institutions of comparative constitutional law, and the underpinning theory of constitutionalism for this relationship. The institutional dimension of the constitutional management of climate change must go beyond courts and rights to processes and institutions in the two political branches of the state. The normative theory of climate constitutionalism—why should climate change be a constitutional subject on a global scale?—should address itself to the matter of how that question can be answered from a wider and more pluralistic set of normative standpoints than simply only liberalism. In other words, how can climate constitutionalism be normatively justified beyond, although not against, liberalism?
Counting when, who and how
Authors: MacDonald Isobel 
Published: July 2022

Abstract
This paper critically examines the possibilities of using the British Museum’s collection database as a research tool to examine acquisition history. It publishes initial findings from the author’s research into the history of the collection through a quantitative analysis of collection data. Rather than focusing on individual collectors, collections or areas of the collection, it takes a high-level comprehensive view of the current body of material, across time, departments and material. The paper asks three questions of the database: when did objects enter the museum’s collection, from whom and how? Through a numerical analysis, acquisition patterns are revealed which both challenge and augment our understanding of the history of the collection.
Acute appendicitis in the context of De Garengeot hernia: a case report
Authors: Shellman Zachary , Worku Dawit , Kulkarni Nikhil 
Published: July 2022

Abstract
De Garengeot hernia is a rare type of hernia so called when the vermiform appendix is found within the hernia sac of a femoral hernia. For the appendix to be inflamed is yet more uncommon. We present the case of a 61-year-old man who presented with a painful right groin lump. Computed tomography imaging reported an inguinal hernia containing a non-inflamed appendix however, intraoperative findings confirmed a femoral hernia containing an appendix with a necrotic tip. As such, these cases prove a diagnostic challenge as not only are the clinical findings illusive, but the radiological findings are often misleading. Diagnosis is often intraoperative and case reports such as this are useful in highlighting this challenging pathology.
A stubborn nasogastric tube: self-knotting of a nasogastric tube
Authors: Tsandiraki Justin , Tendai Joylene , Likiliwike Arnold D , Moirana Ezekiel N , Msuya David , Tarmohamed Murad 
Published: July 2022

Abstract
Nasogastric tubes (NGT) are widely used and generally harmless as such, complications are uncommon. NGT knotting is one such complication. We report a 45-month-old female with spontaneously knotted NGT that was identified and safely removed without complications. NGT knotting detection needs a high index of suspicion; if not detected and managed in a proper way, it may lead to severe complications. We discuss this case to raise awareness of this complication and how to minimize the likelihood of it happening and improve patient outcome.
Cross-correlation between Planck CMB lensing potential and galaxy catalogues from HELP
Authors: Saraf Chandra Shekhar , Bielewicz P , Chodorowski M 
Published: July 2022

ABSTRACT
We present the study of cross-correlation between Cosmic Microwave Background (CMB) gravitational lensing potential map released by the Planck collaboration and photometric redshift galaxy catalogues from the Herschel Extragalactic Legacy Project (HELP), divided into four sky patches: NGP, Herschel Stripe-82, and two halves of SGP field, covering in total ∼660 deg2 of the sky. We estimate the galaxy linear bias parameter, b0, from joint analysis of cross-power spectrum and galaxy autopower spectrum using Maximum Likelihood Estimation technique to obtain values ranging from 0.70 ± 0.01 for SGP Part-2 to 1.02 ± 0.02 for SGP Part-1 field. We also estimate the amplitude of cross-correlation and find the values spanning from 0.67 ± 0.18 for SGP Part-2 to 0.80 ± 0.23 for SGP Part-1 field, respectively. For NGP and SGP Part-1 fields, the amplitude is consistent with the expected value for the standard cosmological model within $\sim 1\, \sigma$, while for Herschel Stripe-82 and SGP Part-2, we find the amplitude to be smaller than expected with $\sim 1.5\, \sigma$ and $\sim 2\, \sigma$ deviation, respectively. We perform several tests on various systematic errors to study the reason for the deviation, however, value of the amplitude turns out to be robust with respect to these errors. The only significant change in the amplitude is observed when we replace the minimum-variance CMB lensing map, used in the baseline analysis, by the lensing map derived from the CMB temperature map with deprojected thermal Sunyaev–Zeldovich signal.
Emergence of a new H i 21-cm absorption component at z ∼ 1.1726 towards the γ-ray blazar PKS 2355-106
Authors: Srianand Raghunathan , Gupta Neeraj , Petitjean Patrick , Momjian Emmanuel , Balashev Sergei A , Combes Françoise , Chen Hsiao-Wen , Krogager Jens-Kristian , Noterdaeme Pasquier , Rahmani Hadi , Baker Andrew J , Emig Kimberly L , Józsa Gyula I G , Kloeckner Hans-Rainer , Moodley Kavilan 
Published: July 2022

ABSTRACT
We report the emergence of a new H i 21-cm absorption at zabs = 1.172 635 in the damped Lyα absorber (DLA) towards the γ-ray blazar PKS 2355-106 (zem∼1.639) using science verification observations (2020 June) from the MeerKAT Absorption Line Survey (MALS). Since 2006, this DLA is known to show a narrow H i 21-cm absorption at zabs = 1.173019 coinciding with a distinct metal absorption-line component. We do not detect significant H i 21-cm optical depth variations from this known H i component. A high-resolution optical spectrum (2010 August) shows a distinct Mg i absorption at the redshift of the new H i 21-cm absorber. However, this component is not evident in the profiles of singly ionized species. We measure the metallicity ([Zn/H] = −(0.77 ± 0.11) and [Si/H]= −(0.96 ± 0.11)) and depletion ([Fe/Zn] = −(0.63 ± 0.16)) for the full system. Using the apparent column density profiles of Si ii, Fe ii, and Mg i, we show that the depletion and the N(Mg i)/N(Si ii) column density ratio systematically vary across the velocity range. The region with high depletion tends to have a slightly larger N(Mg i)/N(Si ii) ratio. The two H i 21-cm absorbers belong to this velocity range. The emergence of zabs = 1.172 635 can be understood if there is a large optical depth gradient over a length-scale of ∼0.35 pc. However, the gas producing the zabs = 1.173 019 component must be nearly uniform over the same scale. Systematic uncertainties introduced by the absorption-line variability has to be accounted for in experiments measuring the variations of fundamental constants and cosmic acceleration even when the radio emission is apparently compact as in PKS 2355-106.
Quasar cosmology: dark energy evolution and spatial curvature
Authors: Bargiacchi G , Benetti M , Capozziello S , Lusso E , Risaliti G , Signorini M 
Published: July 2022

ABSTRACT
We analyse some open debates in cosmology in light of the most updated quasar (QSO) sample, covering a wide redshift range up to $\mathit{ z}$ ∼ 7.5, combined with type Ia supernovae (SNe) and baryon acoustic oscillations (BAOs). Indeed, extending the cosmological analyses with high-redshift data is key to distinguishing between different cosmological models that are degenerate at low redshifts, and allowing better constraints on a possible dark energy (DE) evolution. Also, we discuss combinations of BAO, SNe, and QSO data to understand their compatibility and implications for extensions of the standard cosmological model. Specifically, we consider a flat and non-flat ΛCDM cosmology, a flat and non-flat DE model with a constant DE equation of state parameter (w), and four flat DE models with variable w, namely the Chevallier–Polarski–Linder and Jassal–Bagla–Padmanabhan models, and an ‘exponential’, and Barboza–Alcaniz parametrizations. We find that a joint analysis of QSO+SNe with BAO is only possible in the context of a flat Universe. Indeed BAO confirms the flatness condition assuming a curved geometry, whilst SNe + QSO show evidence of a closed space. We also find ΩM,0 = 0.3 in all data sets assuming a flat ΛCDM model. Yet, all the other models show a statistically significant deviation at 2-3 σ with the combined SNe + SO + BAO data set. In the models where DE density evolves with time, SNe + QSO + BAO data always prefer ΩM,0 &gt; 0.3, w0 &lt; −1 and wa &gt; 0. This DE phantom behaviour is mainly driven by SNe + QSO, while BAO are closer to the flat ΛCDM model.
LyC escape from sphinx galaxies in the Epoch of Reionization
Authors: Rosdahl Joakim , Blaizot Jérémy , Katz Harley , Kimm Taysun , Garel Thibault , Haehnelt Martin , Keating Laura C , Martin-Alvarez Sergio , Michel-Dansac Léo , Ocvirk Pierre 
Published: July 2022

ABSTRACT
We measure escape fractions, fesc, of ionizing radiation from galaxies in the sphinx suite of cosmological radiation-hydrodynamical simulations of reionization, resolving haloes with $M_{\rm vir}\gtrsim 7.5 \times 10^7 \ {\rm {M}_{\odot }}$ with a minimum cell width of ≈10 pc. Our new and largest 20 co-moving Mpc wide volume contains tens of thousands of star-forming galaxies with halo masses up to a few times 1011 M⊙. The simulated galaxies agree well with observational constraints of the ultraviolet (UV) luminosity function in the Epoch of Reionization. The escape fraction fluctuates strongly in individual galaxies over time-scales of a few Myr, due to its regulation by supernova and radiation feedback, and at any given time a tiny fraction of star-forming galaxies emits a large fraction of the ionizing radiation escaping into the intergalactic medium. Statistically, fesc peaks in intermediate-mass, intermediate-brightness, and low-metallicity galaxies (M* ≈ 107 M⊙, M1500 ≈ −17, Z ≲ 5 × 10−3 Z⊙), dropping strongly for lower and higher masses, brighter and dimmer galaxies, and more metal-rich galaxies. The escape fraction correlates positively with both the short-term and long-term specific star formation rate. According to sphinx, galaxies too dim to be yet observed, with ${M_{1500}}\gtrsim -17$, provide about 55 per cent of the photons contributing to reionization. The global averaged fesc naturally decreases with decreasing redshift, as predicted by UV background models and low-redshift observations. This evolution is driven by decreasing specific star formation rates over cosmic time.