bluuebunny/crossref_metadata_2025_split huggingface dataset:
The protective effects of Xuebijing injection on intestinal injuries of mice exposed to irradiation
Authors: Dong Yinping , Zhang YuanYang , Wang Xinyue , Li Wenxuan , Zhang Junling , Lu Lu , Dong Hui , Fan Saijun , Meng Aimin , Li Deguan 
Published: November 2022

AbstractBackgroundGastrointestinal (GI) injury is one of the most common side effects of radiotherapy. However, there is no ideal therapy method except for symptomatic treatment in the clinic. Xuebijing (XBJ) is a traditional Chinese medicine, used to treat sepsis by injection. In this study, the protective effects of XBJ on radiation‐induced intestinal injury (RIII) and its mechanism were explored.MethodsThe effect of XBJ on survival of irradiated C57BL/6 mice was monitored. Histological changes including the number of crypts and the length of villi were evaluated by H&E. The expression of Lgr5+ intestinal stem cells (ISCs), Ki67+ cells, villin and lysozymes were examined by immunohistochemistry. The expression of cytokines in the intestinal crypt was detected by RT‐PCR. DNA damage and apoptosis rates in the small intestine were also evaluated by immunofluorescence.ResultsIn the present study, XBJ improved the survival rate of the mice after 8.0 and 9.0 Gy total body irradiation (TBI). XBJ attenuated structural damage of the small intestine, maintained regenerative ability and promoted proliferation and differentiation of crypt cells, decreased apoptosis rate and reduced DNA damage in the intestine. Elevation of IL‐6 and TNF‐α was limited, but IL‐1, TNF‐𝛽 and IL‐10 levels were increased in XBJ‐treated group after irradiation. The expression of Bax and p53 were decreased after XBJ treatment.ConclusionsTaken together, XBJ provides a protective effect on RIII by inhibiting inflammation and blocking p53‐related apoptosis pathway.
Fine Pore‐Structure Engineering by Ligand Conformational Control of Naphthalene Diimide‐Based Semiconducting Porous Coordination Polymers for Efficient Chemiresistive Gas Sensing
Authors: Xue Ziqian , Zheng Jia‐Jia , Nishiyama Yusuke , Yao Ming‐Shui , Aoyama Yoshitaka , Fan Zeyu , Wang Ping , Kajiwara Takashi , Kubota Yoshiki , Horike Satoshi , Otake Ken‐ichi , Kitagawa Susumu 
Published: November 2022

AbstractExploring new porous coordination polymers (PCPs) that have tunable structure and conductivity is attractive but remains challenging. Herein, fine pore structure engineering by ligand conformation control of naphthalene diimide (NDI)‐based semiconducting PCPs with π stacking‐dependent conductivity tunability is achieved. The π stacking distances and ligand conformation in these isoreticular PCPs were modulated by employing metal centers with different coordination geometries. As a result, three conjugated PCPs (Co−pyNDI, Ni−pyNDI, and Zn−pyNDI) with varying pore structure and conductivity were obtained. Their crystal structures were determined by three‐dimensional electron diffraction. The through‐space charge transfer and tunable pore structure in these PCPs result in modulated selectivity and sensitivity in gas sensing. Zn−pyNDI can serve as a room‐temperature operable chemiresistive sensor selective to acetone.
NMR and DFT Studies with a Doubly Labelled15N/6LiS‐Trifluoromethyl Sulfoximine Reveal Why a Directedortho‐Lithiation Requires an Excess ofn‐BuLi
Authors: Hédouin Matthieu , Barthelemy Anne‐Laure , Vanthuyne Nicolas , Besrour Hend , Maddaluno Jacques , Magnier Emmanuel , Oulyadi Hassan 
Published: November 2022

AbstractThis work shows why it is imperious to use an excess of butyllithium for a directedortho‐lithiation of a trifluoromethyl sulfoximine. The analysis of mixtures ofn‐BuLi and sulfoximine1in THF‐d8using {1H,6Li,13C,15N,19F} NMR experiments at low temperatures reveal that a first deprotonation occurs that leads to dimeric and tetrameric N‐lithiated sulfoximine (93 : 7). Using an excessn‐BuLi (5 equivalents), the second deprotonation on theortho‐position of the aromatic occurs. Six species were observed and characterized on the way. It includes three aggregates involving a sulfoximine: i) a [dilithiated sulfoximine/(n‐BuLi)] dimer solvated by four molecules of THF (Agg2, 39 %); ii) a [dilithiated sulfoximine/(n‐BuLi)3] tetramer solvated by six molecules of THF (Agg3, 39 %); iii) a [dilithiated sulfoximine/(n‐BuOLi)3] tetramer solvated by four molecules of THF (Agg1, 22 %). A DFT study afforded optimized solvated structures for all these aggregates, fully consistent with the NMR data.
Toward Precise Antitumoral Photodynamic Therapy Using a Dual Receptor‐Mediated Bioorthogonal Activation Approach
Authors: Chu Jacky C. H. , Wong Clarence T. T. , Ng Dennis K. P. 
Published: November 2022

AbstractTargeted delivery and specific activation of photosensitizers can greatly improve the treatment outcome of photodynamic therapy. To this end, we report herein a novel dual receptor‐mediated bioorthogonal activation approach to enhance the tumor specificity of the photodynamic action. It involves the targeted delivery of a biotinylated boron dipyrromethene (BODIPY)‐based photosensitizer, which is quenched in the native form by the attached 1,2,4,5‐tetrazine unit, and an epidermal growth factor receptor (EGFR)‐targeting cyclic peptide conjugated with a bicycle[6.1.0]non‐4‐yne moiety. Only for cancer cells that overexpress both the biotin receptor and EGFR, the two components can be internalized preferentially where they undergo an inverse electron‐demand Diels–Alder reaction, leading to restoration of the photodynamic activity of the BODIPY core. By using a range of cell lines with different expression levels of these two receptors, we have demonstrated that this stepwise “deliver‐and‐click” approach can confine the photodynamic action on a specific type of cancer cells.
A Highly Compatible Phototrophic Community for Carbon‐Negative Biosynthesis
Authors: Li Chaofeng , Wang Ruoyu , Wang Jiawei , Liu Liangxu , Li Hengrun , Zheng Haotian , Ni Jun 
Published: November 2022

AbstractCO2 sequestration engineering is promising for carbon‐negative biosynthesis, and artificial communities can solve more complex problems than monocultures. However, obtaining an ideal photosynthetic community is still a great challenge. Herein, we describe the development of a highly compatible photosynthetic community (HCPC) by integrating a sucrose‐producing CO2 sequestration module and a super‐coupled module. The cyanobacteria CO2 sequestration module was obtained using stepwise metabolic engineering and then coupled with the efficient sucrose utilization module Vibrio natriegens. Integrated omics analysis indicated that enhanced photosynthetic electron transport and extracellular vesicles promote intercellular communication. Additionally, the HCPC was used to channel CO2 into valuable chemicals, enabling the overall release of −22.27 to −606.59 kgCO2e kg−1 in the end products. This novel light‐driven community could facilitate circular economic implementation in the future.
A Combined XPS and Computational Study of the Chemical Reduction of BMP‐TFSI by Lithium
Authors: Forster‐Tonigold K. , Buchner F. , Bansmann J. , Behm R. J. , Groß A. 
Published: November 2022

AbstractInvited for this month's cover picture is the work of Prof. Groß’ and Prof. Behm's groups at the Helmholtz Institute Ulm (HIU) Electrochemical Energy Storage and Ulm University. The cover picture shows the model study on the chemical reactions of the ionic liquid BMP‐TFSI with Li atoms. The combined study of XPS experiments and DFT calculations identified various initial products in the solid‐electrolyte interphase formation. Read the full text of the Research Article at 10.1002/batt.202200307.
Nanostructured material‐based optical and electrochemical detection of amoxicillin antibiotic
Authors: Imran Mohd , Ahmed Shahzad , Abdullah Ahmad Zuhairi , Hakami Jabir , Chaudhary Anis Ahmad , Rudayni Hassan Ahmad , Khan Salah‐Ud‐Din , Khan Afzal , Basher Nosiba Suliman 
Published: November 2022

AbstractThe penicillin derivative amoxicillin (AMX) plays an important role in treating various types of infections caused by bacteria. However, excessive use of AMX may have negative health effects. Therefore, it is of utmost importance to detect and quantify the AMX in pharmaceutical drugs, biological fluids, and environmental samples with high sensitivity. Therefore, this review article provides valuable and up‐to‐date information on nanostructured material‐based optical and electrochemical sensors to detect AMX in various biological and chemical samples. The role of using different nanostructured materials on the performance of important optical sensors such as colorimetric sensors, fluorescence sensors, surface‐enhanced Raman scattering sensors, chemiluminescence/electroluminescence sensors, optical immunosensors, optical fibre‐based sensors, and several important electrochemical sensors based on different electrode types have been discussed. Moreover, nanocomposites, polymer, and MXenes‐based electrochemical sensors have also been discussed, in which such materials are being used to further enhance the sensitivity of these sensors. Furthermore, nanocomposite‐based photo‐electrochemical sensors and the market availability of biosensors including AMX have also been discussed briefly. Finally, the conclusion, challenges, and future perspectives of the above‐mentioned sensing techniques for AMX detection are presented.
Modeling an immune response to influenza A virus infection in alveolar epithelial cells
Authors: Miller Marissa L. , Brown Deborah M. , Wysocki Tadeusz A. 
Published: November 2022

AbstractInfluenza A viruses (IAV) have been the cause of several influenza pandemics in history and are a significant threat for the next global pandemic. Hospitalized influenza patients often have excess interferon production and a dysregulated immune response to the IAV infection. Obtaining a better understanding of the mechanisms of IAV infection that induce these harmful effects would help drug developers and health professionals create more effective treatments for IAV infection and improve patient outcomes. IAV stimulates viral sensors and receptors expressed by alveolar epithelial cells, like RIG‐I and toll‐like receptor 3 (TLR3). These two pathways coordinate with one another to induce expression of type III interferons to combat the infection. Presented here is a queuing theory‐based model of these pathways that was designed to analyze the timing and amount of interferons produced in response to IAV single stranded RNA and double‐stranded RNA detection. The model accurately represents biological data showing the necessary coordination of the RIG‐I and TLR3 pathways for effective interferon production. This model can serve as the framework for future studies of IAV infection and identify new targets for potential treatments.
Peptoid‐Peptide Hybrid Analogs of the Enterococcus faecalis Fsr Auto‐Inducing Peptide (AIP) Reveal Crucial Structure‐Activity Relationships
Authors: McBrayer Dominic N. , Ghosh Uttam , Lella Muralikrishna , Cameron Crissey D. , Tal‐Gan Yftah 
Published: November 2022

AbstractAs multidrug‐resistant bacteria become a more pressing risk to human health, alternate approaches to treating bacterial infections are being increasingly investigated. Enterococcus faecalis is an opportunistic pathogen responsible for a large percentage of secondary enterococci infections. Its pathogenicity has been shown to be largely dependent on a cell‐density communication mechanism, termed quorum sensing. In this study, we conducted a systematic investigation of the lactone‐containing macrocyclic signaling peptide used by E. faecalis for Fsr‐mediated communication, termed gelatinase biosynthesis activating pheromone (GBAP). Specifically, through a combination of the on‐resin sub‐monomer and solution phase peptoid building block synthesis approaches, we successfully synthesized a library of peptoid‐peptide hybrid analogs of GBAP and determined the biological effects associated with the introduction of the peptoid (N‐alkyl glycine derivative) modifications. Within the macrocycle region of the peptide, as have been seen with other modifications, the F7 site was unusually tolerant toward peptoid modification, compared with other macrocyclic sites. Interestingly, within the exocyclic tail, peptoid modification at the N2 site completely abolished activity, a first for a single tail modification.
Fat mass and obesity‐associated protein alleviates Aβ1–40 induced retinal pigment epithelial cells degeneration via PKA/CREB signaling pathway
Authors: Hu Yifan , Chen Jieqiong , Wang Yuwei , Sun Junran , Huang Peirong , Feng Jingyang , Liu Te , Sun Xiaodong 
Published: November 2022

AbstractAmyloid‐β (Aβ) is thought to be a critical pathologic factor of retinal pigment epithelium (RPE) degeneration in age‐related macular degeneration (AMD). Aβ induces inflammatory responses in RPE cells and recent studies demonstrate the N6‐methyladenosine (m6A) regulatory role in RPE cell inflammation. m6A is a reversible epigenetic posttranslational modification, but its relationship with Aβ‐induced RPE degeneration is yet to be thoroughly investigated. The present study explored the role and mechanism of m6A in Aβ‐induced RPE degeneration model. This model was induced via intravitreally injecting oligomeric Aβ and the morphology of its retina was analyzed. One of m6A demethylases, the fat mass and obesity‐associated (FTO) gene expression, was assessed. An m6A‐messenger RNA (mRNA) epitranscriptomic microarray was employed for further bioinformatic analyses. It was confirmed that Aβ induced FTO upregulation within the RPE. Hypopigmentation alterations and structural disorganization were observed in Aβ‐treated eyes, and inhibition of FTO exacerbated retinal degeneration and RPE impairment. Moreover, the m6A‐mRNA epitranscriptomic microarray suggested that protein kinase A (PKA) was a target of FTO, and the PKA/cyclic AMP‐responsive element binding (CREB) signaling pathway was involved in Aβ‐induced RPE degeneration. m6A‐RNA binding protein immunoprecipitation confirmed that FTO demethylated PKA within the RPE cells of Aβ‐treated eyes. Altered expression of PKA and its downstream targets (CREB and brain‐derived neurotrophic factor) was confirmed by quantitative reverse‐transcription polymerase chain reaction and Western blot analyses. Hence, this study's findings shed light on FTO‐mediated m6A modification in Aβ‐induced RPE degeneration and indicate potential therapeutic targets for AMD.
Nobiletin and xanthohumol counteract the TNFα‐mediated activation of endothelial cells through the inhibition of the NF‐κB signaling pathway
Authors: Corrado Chiara , Barreca Maria Magdalena , Raimondo Stefania , Diana Patrizia , Pepe Giacomo , Basilicata Maria Giovanna , Conigliaro Alice , Alessandro Riccardo 
Published: November 2022

AbstractAngiogenesis, a process characterized by the formation of new blood vessels from pre‐existing ones, is a crucial step in tumor growth and dissemination. Given the ability of tumors to interfere with multiple or different molecular pathways to promote angiogenesis, there is an increasing need to therapeutically block tumor progression by targeting multiple antiangiogenic pathways. Natural polyphenols present health‐protective properties, which are likely attributed to their ability to activate multiple pathways involved in inflammation, carcinogenesis, and angiogenesis. Recently, increased attention has been addressed to the ability of flavonoids, the most abundant polyphenols in the diet, to prevent cancer by suppressing angiogenesis. Here we investigate the mechanisms by which xanthohumol (the major prenylated flavonoid of the hop plant Humulus lupulus L.) and nobiletin (flavonoid from red‐orange Citrus sinensis) can modulate the effects of Tumor Necrosis Factor‐α (TNF‐α) on human umbilical vein endothelial cells (HUVEC). The results reported in this paper show that xanthohumol and nobiletin pretreatment of HUVEC inhibits the effects induced by TNF‐α on cell migration, invasion capability, and colon cancer cell adhesion on the endothelial monolayer. Moreover, the pretreatment reduces metalloproteinases and adhesion molecules' expression. Finally, our results highlight that xanthohumol and nobiletin can counteract the effects of TNF‐α on angiogenesis and invasiveness, mainly through Vascular Endothelial Growth Factor and NF‐κB pathways. Since angiogenesis plays an important pathological role in the progression of several diseases, our findings may provide clues for developing xanthohumol and nobiletin as therapeutic agents against angiogenesis‐associated diseases.
Agranulocytosis in systemic lupus erythematosus: A case report
Authors: Frikha Olfa , Ben Salah Raida , Mefteh Ansar , Frikha Faten , Snoussi Mouna , Marzouk Sameh , Bahloul Zouhir 
Published: November 2022

AbstractAgranulocytosis is a rare acute condition characterized by severe a < gft (neutropenia in which the neutrophils count is less than 100/mm3. It can be classified into two categories, inherited, and acquired. Acquired agranulocytosis is not commonly caused by auto‐immune diseases such as systemic lupus erythematosus (SLE). We report a case of a patient suffering from agranulocytosis related to SLE at disease onset, associated with other rare disease involvements.
Gastric volvulus: An uncommon and life threatening cause of acute gastric dilatation in a young male: A case report
Authors: Bhatta Naveen Chandra , Kathayat Karisma , Dahal Sampada , Shrivastava Bijay , Shakya Niliza , Shrestha Asish , Nepal Bikash , Sthapit Rakesh 
Published: November 2022

AbstractGastric volvulus leading to acute gastric dilatation is a surgical emergency that should be considered as a differential in patients who present to the emergency department with severe epigastric pain and evidence of gastric outlet obstruction. This condition requires a high index of suspicion that enables early diagnosis and treatment.
Complicated jejunal diverticulitis: A case report and review of literature
Authors: Scheese Daniel , Alwatari Yahya , Khan Jamal , Slaughter Ashley 
Published: November 2022

AbstractJejunal diverticulitis is an uncommon pathology wherein a delay in diagnosis can lead to significant morbidity and mortality. We report a case of such diverticula requiring operative management, after patient failed non‐operative management, likely due to advanced jejunal inflammation from a delay in diagnosis and subsequent management.
Clinical whole‐exome sequencing analysis reveals a novel missense COL11A1 mutation resulting in an 18‐week Iranian male aborted fetus with Fibrochondrogenesis 1: A case report
Authors: Mirtavoos‐Mahyari Hanifeh , Ajami Sanaz , Mehrtash Amirhosein , Marashiyan Seyedeh Mahya , Bahreini Farbod , Sheikhy Kambiz , Ghanbari Sogol , Ardeshirdavani Amin 
Published: November 2022

AbstractFibrochondrogenesis 1, an autosomal recessive syndrome, is a rare disease that causes short‐limbed skeletal dysplasia. Mutations in the gene encoding the α1 chain of type XI collagen (COL11A1) are seen to be the main cause of this disease. We present an 18‐week Iranian male aborted fetus with Fibrochondrogenesis 1 from consanguineous parents. Whole‐exome sequencing revealed a novel missense variant from G to A in exon 45 of 68 in the COL11A1 gene (NM_080629.2: c.3440G > A, [p.G1147E, g.103404625]). The mutation was confirmed by Sanger sequencing and further, MutationTaster predicted this variant to be disease‐causing. Bioinformatic analysis suggests that this variant is highly conserved in both nucleotide and protein levels, suggesting that it has an important function in the proper role of COL11A1 protein. In silico analysis suggests that this mutation alters the COL11A1 protein structure through a Glycine to Glutamic acid substitution.
Acquired childhood aphasia as a consequence of COVID‐19 and its differential diagnosis from speech–language pathologist perspective: A case study
Authors: Fameen Ridha , K. Rinsha Pravin , S. Pooja , V. Rashmi , Bhattarai Biraj , B. P. Abhishek 
Published: November 2022

AbstractIt is essential to be more vigilant in understanding impact of COVID‐19 on children's speech and language skills. As studies in these lines are very sparse, it is imperative to profile these children and derive accurate diagnosis. Accurate diagnosis aids Speech‐Language Pathologists (SLPs) to render speech and Language therapy systematically.
Lithium Dependent Electrochemistry of p‐Type Nanocrystalline CuCrO2 Films
Authors: Chown Amanda L. , Yeasmin Humaira , Paudel Rajendra , Comes Ryan B. , Farnum Byron H. 
Published: November 2022

AbstractCuCrO2 nanocrystals were synthesized and fabricated into mesoporous thin films to study their electrochemical properties, where a strong [Li+] dependence was observed. An anodic shift in the Cu2+/+ redox potential was observed with increased [Li+] in the electrolyte, in addition to the growth of a new redox feature at E1/2=−0.43 V vs Fc+/0. This new feature was attributed to Cu2+/+ redox chemistry accompanied by Li+ occupation in copper vacancy surface defects. The equilibrium constant and maximum charge for Li+ occupation were determined to be K=0.057 M−1 and 15.5 mC, respectively. The maximum charge was close to the expected value of 11 mC based on the measured concentration of copper vacancies. The pronounced Li+ dependent electrochemistry suggests that CuCrO2 behaves similarly to cathodes in Li‐ion batteries. Thus, chronopotentiometry experiments revealed a 7.8 mA h g−1 charge capacity at cycle 2 and increasing cycling efficiency from 83 to 91 % over 10 cycles. However, a pronounced decrease in charge capacity was observed with increased cycles, attributed to a loss in lithium‐coupled electrochemistry. These studies add to our understanding of surface defects in p‐type oxides and their effect on hole recombination in solar cell devices.
Highly soluble organic nitrate additives for practical lithium metal batteries
Authors: Wang Zhe , Hou Li‐Peng , Li Zheng , Liang Jia‐Lin , Zhou Ming‐Yue , Zhao Chen‐Zi , Zeng Xiaoyuan , Li Bo‐Quan , Chen Aibing , Zhang Xue‐Qiang , Dong Peng , Zhang Yingjie , Huang Jia‐Qi , Zhang Qiang 
Published: November 2022

AbstractThe stability of lithium metal anodes essentially dictates the lifespan of high‐energy‐density lithium metal batteries. Lithium nitrate (LiNO3) is widely recognized as an effective additive to stabilize lithium metal anodes by forming LiNxOy‐containing solid electrolyte interphase (SEI). However, its poor solubility in electrolytes, especially ester electrolytes, hinders its applications in lithium metal batteries. Herein, an organic nitrate, isosorbide nitrate (ISDN), is proposed to replace LiNO3. ISDN has a high solubility of 3.3 M in ester electrolytes due to the introduction of organic segments in the molecule. The decomposition of ISDN generates LiNxOy‐rich SEI, enabling uniform lithium deposition. The lifespan of lithium metal batteries with ISDN significantly increases from 80 to 155 cycles under demanding conditions. Furthermore, a lithium metal pouch cell of 439 Wh kg−1 delivers 50 cycles. This work opens a new avenue to develop additives by molecular modifications for practical lithium metal batteries.