bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reactive sintering principle and compressive properties of porous AZ91 magnesium alloy foams produced by powder metallurgy approach
Authors: Agbedor S.O. , Yang D. , Chen J. , Saleh B. , Seidu S.O. , Qiu C. , Jiang J. , Ma A. 
Published: February 2022

AbstractPorous magnesium alloy foams have gained tremendous interest from scientists because of their super lightweight, unique mechanical and physical properties. Despite numerous studies suggesting these advanced materials for structural and functional applications, their manufacturing processes remain poorly understood. In this paper, the porous Mg‐9 wt. %Al‐1 wt. % Zn alloy foam was prepared through the reactive sintering principle (i. e. the element metal powder reaction principle) by using the powder metallurgical method that is combined with a pore‐making agent. The chemical and phase compositions of the cell wall microstructure were investigated by X‐ray diffraction and scanning electron microscope equipped with energy dispersive spectrometer. The compressive properties of the foams were evaluated by quasi‐static compression testing. The results of the analysis reveal that low‐temperature sintering can produce qualitative magnesium alloy foams with good mechanical properties by taking advantage of the intermetallic/or intermediate compounds which are formed in the cell wall through metal elements powder diffusion and reaction. Particularly, the foam samples sintered at 380 °C for 12 h gave the best compressive properties owing to the alloy intermetallic contents and the relative density of the foams.
Maternal Isocaloric High‐Fat Diet Induces Liver Mitochondria Maladaptations and Homeostatic Disturbances Intensifying Mitochondria Damage in Response to Fructose Intake in Adult Male Rat Offspring
Authors: Souza Aline F. P. , Woyames Juliana , Miranda Rosiane A. , Oliveira Lorraine S. , Caetano Bruna , Martins Isabela L. , Souza Manuella S. , Andrade Cherley B. V. , Bento‐Bernardes Thais , Bloise Flavia F. , Fortunato Rodrigo S. , Trevenzoli Isis H. , Souza Luana L. , Pazos‐Moura Carmen C. 
Published: February 2022

ScopePerinatal maternal obesity and excessive fructose consumption have been associated with liver metabolic diseases. The study investigates whether moderate maternal high‐fat diet affects the liver mitochondria responses to fructose intake in adult offspring.Methods and ResultsWistar female rats have received a standard diet (mSTD) or high‐fat diet (mHFD) (9% and 28.6% fat, respectively), before mating until the end of lactation. Male offspring were fed standard diet from weaning to adulthood and received water or fructose‐drinking water (15%) from 120 to 150 days old. Fructose induces liver mitochondrial ultrastructural alterations with higher intensity in mHFD offspring, accompanied by reduced autophagy markers. Isolated mitochondria respirometry shows unaltered ATP‐coupled oxygen consumption with increased Atp5f1b mRNA only in mHFD offspring. Fructose increases basal respiration and encoding complex I‐III mRNA, only in mSTD offspring. Uncoupled respiration is lower in mHFD mitochondria that are unable to exhibit fructose‐induced increase Ucp2 mRNA. Fructose decreases antioxidative defense markers, increases unfolded protein response and insulin resistance only in mHFD offspring without fructose‐induced hepatic lipid accumulation.ConclusionMitochondrial dysfunction and homeostatic disturbances in response to fructose are early events evidencing the higher risk of fructose damage in the liver of adult offspring from dams fed an isocaloric moderate high‐fat diet.
Brief assessment of cognitive function in myotonic dystrophy: Multicenter longitudinal study using computer‐assisted evaluation
Authors: Deutsch Gayle K. , Hagerman Katharine A. , Sampson Jacinda , Dent Gersham , Dekdebrun Jeanne , Parker Dana M. , Thornton Charles A. , Heatwole Chad R. , Subramony Sub H. , Mankodi Ami K. , Ashizawa Tetsuo , Statland Jeffrey M. , Arnold W. David , Moxley Richard T. , Day John W. ,   Myotonic Dystrophy Clinical Research Network
Published: February 2022

AbstractIntroduction/AimsMyotonic dystrophy type 1 (DM1) is known to affect cognitive function, but the best methods to assess central nervous system involvement in multicenter studies have not been determined. In this study our primary aim was to evaluate the potential of computerized cognitive tests to assess cognition in DM1.MethodsWe conducted a prospective, longitudinal, observational study of 113 adults with DM1 at six sites. Psychomotor speed, attention, working memory, and executive functioning were assessed at baseline, 3 months, and 12 months using computerized cognitive tests. Results were compared with assessments of muscle function and patient reported outcomes (PROs), including the Myotonic Dystrophy Health Index (MDHI) and the 5‐dimension EuroQol (EQ‐5D‐5L) questionnaire.ResultsBased on intraclass correlation coefficients, computerized cognitive tests had moderate to good reliability for psychomotor speed (0.76), attention (0.82), working memory speed (0.79), working memory accuracy (0.65), and executive functioning (0.87). Performance at baseline was lowest for working memory accuracy (P < .0001). Executive function performance improved from baseline to 3 months (P < .0001), without further changes over 1 year. There was a moderate correlation between poorer executive function and larger CTG repeat size (r = −0.433). There were some weak associations between PROs and cognitive performance.DiscussionComputerized tests of cognition are feasible in multicenter studies of DM1. Poor performance was exhibited in working memory, which may be a useful variable in clinical trials. Learning effects may have contributed to the improvement in executive functioning. The relationship between PROs and cognitive impairment in DM1 requires further study.
Synthesis of Cu nanoparticles in a chitosan entrapped copolymer matrix for photocatalytic reduction of textile dye and column adsorption of heavy metal ions from water
Authors: Bhangi Bidyut Kumar , Ray Samit Kumar 
Published: February 2022

AbstractPolymer metal nano‐composites (PMNC) were synthesized by integrating different weight percentage of chitosan (CS), N,N′‐methylenebisacrylamide (MBA) crosslinked poly(acrylic acid‐co‐hydroxyethyl methacrylate) copolymer and Cu nanoparticles (CuNPs). CuNPs were generated in situ during polymerization by reducing CuSO4.5H2O with ascorbic acid. The presence of the CuNPs in the polymer network, functionality, crystallinity, morphology, size distribution of the CuNPs, elemental composition, thermal characteristics, network parameters, pH sensitivity, and strength of the composites was evaluated. The CuNP‐loaded PMNC4 composite prepared with 10:1 acrylic acid : hydroxyethyl methacrylate molar ratio, 1 wt% each of initiator and MBA crosslinker and 4 wt% CS showed a photodegradation efficiency of 64% in 5 h for 50 mg/L methyl violet dye in water. The same polymer showed a rejection of 91.45% and a mass transfer coefficient of 4.14 × 10−5 cm/s for continuous adsorption of 20 mg/L Pb(II) ion in water in a fixed bed of height 22 mm for an inflow rate of 30 ml/min.
Embedding equity into school mental health theory, research, and practice: An introduction to the special issue series
Authors: Exner‐Cortens Deinera , Gaias Larissa , Splett Joni W. , Jones Janine , Walker Whitney 
Published: February 2022

AbstractIn this article, we present an introduction and overview for a two‐part special issue series focused on embedding equity into school mental health through theory, research, and practice. The papers in Part 1 of the special issue series cover critical topics for advancing equitable school mental health, including the centering of community and youth perspectives; a focus on reducing disproportionality in discipline practices; and details on equity‐focused interventions. In Part 2, papers focus on integrating race and racial equity into school mental health frameworks; integrating a racial equity lens into trauma‐informed school practices; addressing outcomes that have disproportionate impacts on youth of color; and exploring domains of injustice and oppression beyond racial inequity. We hope that the topics discussed in this special issue series move us towards providing equitable and just school mental health services for all children and youth.
Plasma‐water‐based nitrogen fixation: Status, mechanisms, and opportunities
Authors: Huang Zhongzheng , Xiao Ao , Liu Dawei , Lu Xinpei , Ostrikov Kostya (Ken) 
Published: February 2022

AbstractNitrogen‐based crop fertilizers are the most important industrial chemicals supporting the global food supply. Plasma‐water‐based nitrogen fixation (PWBNF) provides a clean, sustainable, and flexible alternative, which is amenable for decentralized, small‐to‐medium‐scale production systems. This process is based on the targeted activation of N2 or air molecules by plasmas. Plasma can interact with water molecules, water droplets, and water layers through the plasma physical and chemical mechanisms. This review summarizes the current state of the art of PWBNF and provides insights into the effective mechanisms for the synthesis of NH3, NO2− and NO3− in highly reactive plasma environments. The opportunities and challenges for this plasma‐enabled approach are identified to guide the development of sustainable nitrogen fixation technology.
Short‐term effect and effect on rate of lung function decline after surgery for neuromuscular or syndromic scoliosis
Authors: Veldhoen Esther S. , de Vries Anneloes , Schlosser Tom P. C. , Kruyt Moyo C. , van Eijk Ruben P. A. , Tersmette Joyce M. , Hulzebos Erik H. , van der Pol Ludo W. , Wösten‐van Asperen Roelie M. , van der Ent Cornelis K. 
Published: February 2022

AbstractIntroductionUnderstanding the impact of scoliosis surgery on lung function is important for counseling patients about risks and benefits of surgery. We prospectively compared the trends in lung function test (LFT) results before and after scoliosis surgery in children with neuromuscular diseases or dysmorphic syndromes. We hypothesized a stabilization.MethodsWe prospectively included children with neuromuscular or syndromic scoliosis able to perform LFTs. We studied (forced) vital capacity ([F]VC), ratio of forced expiratory volume in 1 s (FEV1) and FVC, and peak expiratory flow (PEF). Preoperative LFT results were compared with results 3–4 months after surgery. The mean monthly change in LFT results up to 2 years after surgery was compared with the preoperative natural history using linear mixed‐effects models.ResultsWe included 43 patients. No significant change was observed in absolute values of (F)VC, FEV1/FVC, and PEF before and after surgery. In 23 neuromuscular patients median standardized VC, FVC, and PEF decreased significantly after surgery from 43% to 33%, 42% to 31%, and 51% to 40%, respectively. In 20 syndromic patients, median FVC decreased from 68% to 65%. The monthly rate of change in FVC did not change significantly in both groups with a mean difference of 0.18% (95% CI: −0.27, −0.61) and −0.44% (95% CI: −1.05, 0.16).ConclusionNo stabilization of lung function 3–4 months after scoliosis surgery was observed in children with neuromuscular and syndromic scoliosis with restrictive lung function disease. The effect on the rate of lung function decline remains inconclusive.
Translation of the quality of life questionnaire for primary ciliary dyskinesia (QOL‐PCD) into Hebrew: The Israeli experience
Authors: Amirav Israel , Shoshan Noa B. , Behan Laura , Bar‐Yoseph Ronen , Lavie Moran 
Published: February 2022

AbstractBackgroundPatients with primary ciliary dyskinesia (PCD) have chronic morbidities affecting their quality of life (QOL). Health‐related QOL (HRQOL) has been recognized as an important tool for assessing the burden of PCD on patients and their families. A PCD‐specific HRQOL questionnaire (QOL‐PCD) was developed and validated for the English‐speaking populations. Still, it has not yet been translated into Hebrew or adapted for Israeli PCD patients.MethodsThis describes our translation of the original English version of QOL‐PCD into a Hebrew version. The process involved forward translation by independent translators, construction of a consensus version, back‐translation into the original English version, analysis by the expert committee, and a pretest. The pretest was administered to 20 participants with PCD (the patients and the parents of minor patients) to assess the feasibility and practicality of the tool. Scale and item indices (scale‐level content validity index [S‐CVI] and item‐level content validity index [I‐CVI]) were calculated for content validity.ResultsAll study participants understood the final Hebrew version that the expert committee had approved with no difficulty. The instrument had satisfactory (>0.80) content validity, with S‐CVI indexes of 0.99 for the adult version, 0.86 for the parental version, 0.95 for the adolescent version, and 1.00 for the child version.ConclusionThe English version of a QOL‐PCD was translated into Hebrew and adapted in Israel. This translation is a valid instrument to assess HRQOL in Hebrew‐speaking patients with PCD and their family members. It may be helpful for PCD patient management and research in Israel.
Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes
Authors: Okuyama Shota , Mine Akari , Nakamura Teppei , Ohasi Yusuke , Seto Mayuko , Tada Masako 
Published: February 2022

AbstractCYP2D6 and CYP3A4, which are members of the cytochrome P450 superfamily of metabolic enzymes, play major roles in the metabolism of commonly available drugs. CYP3A4 is involved in the metabolism of 50% of drugs on the market, whereas CYP2D6 is involved in the metabolism of 25% of them. CYP2D6 exhibits a high degree of polymorphic nature in the human population, causing individual differences in CYP2D6 expression and enzymatic activity. Therefore, accurate prediction of drug metabolism and toxicity require a human adult hepatocyte cell model that mimics individual responses in the average population. HepaRG cells, a human hepatocellular carcinoma cell line, is the only cell line that can differentiate into hepatocyte‐like cells with high expression of CYP3A4 but poor expression of CYP2D6. To solve this problem, we developed transgenic HepaRG cell clones expressing either full‐length or spliced CYP2D6 at various levels with an easy monitoring system for CYP2D6 expression in living cells under a fluorescent microscope. As CYP2D6 mRNA, protein, and fluorescence intensity were closely correlated among transgenic HepaRG clones, fluorescence levels will provide a simple tool for quality assurance of CYP2D6‐expressing HepaRG cells. Thus, the package of transgenic HepaRG cell clones expressing CYP2D6 at various levels will provide an improved hepatocyte model that reflects the average or individual reactions in the human population for in vitro studies of drug metabolism and toxicity involving CYP2D6 and CYP3A4.
Network pharmacology reveals potential functional components and underlying molecular mechanisms of Andrographis paniculata in esophageal cancer treatment
Authors: Cheung Man Kit , Yue Grace Gar‐Lee , Gomes Adele Joyce , Wong Eric Chun‐Wai , Lee Julia Kin‐Ming , Kwok Frankie Hin‐Fai , Chiu Philip Wai‐Yan , Lau Clara Bik‐San 
Published: February 2022

AbstractAntitumor and antimetastatic effects of the medicinal herb Andrographis paniculata (AP) in esophageal cancer (EC) have been previously reported. In this study, we aimed to uncover the potential functional components and the underlying molecular mechanisms of AP in EC treatment using network pharmacology and experimental validation. Twenty‐two potential active AP compounds against EC were revealed, including the antitumor/antiinflammatory compounds panicolin, moslosooflavone, and deoxyandrographiside. Epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3), RAC‐alpha serine/threonine‐protein kinase (AKT1), prostaglandin‐endoperoxide synthase 2 (PTGS2), chemokine (C‐X‐C motif) ligand 8 (CXCL8), phosphatidylinositol 4,5‐bisphosphate 3‐kinase subunit alpha (PIK3CA), and toll‐like receptor 4 (TLR4) were most highly ranked among the predicted targets of AP in EC treatment and may play important roles in the anti‐EC effects of AP. KEGG pathway analysis revealed the enrichment of multiple cancer‐related pathways and signaling pathways. Quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) and western blotting validation showed that overnight treatment with 850.3 μg/ml of AP water extract significantly reduced the mRNA expressions of EGFR and AKT in human EC‐109 cells. The presence of panicolin and moslosooflavone in the AP water extract samples were confirmed using LC‐MS against reference standards. This study has comprehensively revealed for the first time the potential functional components of AP in EC and explored the underlying molecular mechanisms. Future studies should characterize the potential pharmacological properties of the other highly ranked yet understudied compounds in AP detected.
The novel oral gonadotropin‐releasing hormone receptor antagonist relugolix is a new option for controlled ovarian stimulation cycles
Authors: Komiya Shinnosuke , Tsuzuki‐Nakao Tomoko , Asai Yoshiko , Inoue Tomoko , Morimoto Yoshiharu , Okada Hidetaka 
Published: February 2022

AbstractPurposeRelugolix is an oral gonadotropin‐releasing hormone antagonist (GnRHant), which was first introduced in 2019. This study investigated the effects of the conventional injectable GnRHant formulation and this new oral GnRHant formulation on controlled ovarian stimulation (COS) cycles.MethodsRelugolix was administered in 126 cycles and conventional GnRHant injection was administered in 658 cycles (controls). The follicle stimulation was performed by an antagonist method, and for final oocyte maturation, recombinant human chorionic gonadotropin (rHCG), or gonadotropin‐releasing hormone agonist (GnRHa), or both (dual trigger) were selected. The number of retrieved oocytes was counted and then they were evaluated for subsequent development up to cleavage stage.ResultsThe number of retrieved oocytes which was the primary outcome of this research was affected by the combination of GnRHant type and the final oocyte maturation agent. The combination of relugolix and a GnRHa trigger showed a significantly lower number of retrieved oocytes (p < 0.001) than the other combinations.ConclusionsRelugolix is a new option for COS cycles, but should be carefully combined with the final maturation agent.Clinical trial approvalThis study was conducted after approval by the Medical Corporation Sankeikai Institutional Ethics Committee (approval number: 2019‐34).
Catalyst‐Free Synthesis of Thioethers through C−N Bond Cleavage of Aminonaphthol/Aminophenol Derivatives
Authors: Suresh Pavithira , Kumari Subramaniyan Prasanna , Krishnan Keerthana , Ganesan Subramaniapillai Selva 
Published: February 2022

AbstractReadily available aminonaphthol/aminophenol derivatives were converted to the corresponding thioethers under catalyst‐free reaction conditions. Environmentally benign aqueous medium was utilized for the transformation of aminonaphthol derivatives to the corresponding thioethers under aerobic reaction conditions. Saturated brine solution was identified as a suitable medium for the synthesis of thioethers from aminophenol derivatives. Control experiments revealed that the nature of leaving group and reaction atmosphere plays a vital role in determining the yield of the products.
Recent Advances in Metal Catalyzed C−H Functionalization with a Wide Range of Directing Groups
Authors: Ahmad Muhammad Siddique , Meguellati Kamel 
Published: February 2022

AbstractC−H bond functionalization is an emerging field with various pharmaceuticals, agrochemicals and dye chemistry applications. We have explored the use of C−H bond functionalization with catalytic metals and various remote/directing groups such as pyridine, pyrimidine, 8‐aminoquinoline or n‐quinoline, 2‐isopropylpyridine, oxazoline,2‐aminopyridine‐1‐oxide, N‐(2‐(methylthio)phenyl), 2‐methoxyiminoacetyl, 2‐amino‐3‐fluoro‐N,N‐dimethylbenzamide, 2‐dimethylaminoethylamine, N‐(2‐aminophenyl)‐acetamide, 5‐methylisoxazole‐3‐carboxamide, oligopeptide, β‐carboline amide, N‐tosylethylenediamine, acetohydrazide, β‐alanine, 3‐amino‐2‐benzylpropanoic acid and 2‐(methylsulfinyl)aniline with metacycles sides. Moreover, these metals employed (Pd, Rh, Ru, Mn, Ni, Fe, Cu or Co) in these reactions have relevant good catalytic properties and can catalyze a wide range of chemical reactions such as cyanations, arylations, alkenylations, allylations, alkylations and alkynylations with a wide range of removable auxiliary were reviewed. Importantly, functionalization of β‐C(sp3)−H, ortho‐(sp2)−H carbonyl compounds, γ‐C(sp3)−H arylation and γ‐C(sp2)−H of amines, amino esters and alkyl acetal are summarized in this review.
Discovery of 2‐Amino‐4H‐1, 3, 4‐thiadiazine‐5(6H)‐one Derivatives and Their In Vitro Antitumor Investigation
Authors: Mohammed Faten Zahran , Rizzk Youstina William , El‐Deen Ibrahim Mohey , Gad Emad M. , El Behery Mohammed , Mahdy Ahmed R. E. 
Published: February 2022

AbstractNovel 2‐Amino‐4H‐1,3,4‐thiadiazine‐5‐(6H)‐one derivatives 3–6 were designed, synthesized, and assessed for their anticancer effects on MCF‐7 and A549 cell lines. The cytotoxicity screening found several active compounds. Meanwhile, compound 5 b exhibited the strongest cytotoxic activity compared to Doxorubicin (DOX). Furthermore, DNA flow cytometry investigation over MCF‐7 cells indicated that compound 5 b demonstrated arrest at G1/S stages of the cell cycle and induction of apoptosis by rising pre‐G1 stage. In addition, the underlying mechanistic studies of compound 5b′s proapoptotic activities revealed that they induced the elevation of P53 and the BAX/BCL‐2 ratio expression that led to a rise in active Caspase 3/7 levels and triggered apoptosis. Finally, Compound 5 b displayed a significant dual topoisomerase IIβ enzyme and β‐tubulin polymerization inhibition.
A New Lipid‐Droplets‐Targeted Fluorescence Probe with Dual‐Reactive Sites for Specific Detection of ClO− in Living Cells
Authors: Li Zhao , Yang Yuan , Yin Pei , Yang Zengming , Zhang Bo , Zhang Shengjun , Han Bingyang , Lv Jiawei , Dong Fenghao , Ma Hengchang 
Published: February 2022

AbstractLipid droplets (LDs) are organelles composed of a lipid core surrounded by a phospholipid monolayer, plays an important role in a variety of physiological processes as well as diseases. In this work, TPAs‐SCH3‐2CN with an enhanced electron D‐π‐A system, is synthesized, which makes itself as an orange emission compound (Em=590 nm) and also have high polarity. It is verified that TPAs‐SCH3‐2CN is an excellent LDs‐targeted probe, and it also sensitive to the ClO− detection in vitro and in cells. Impressively, due to the high lipophilicity, TPAs‐SCH3‐2CN is able to stain the yolk lipids in zebrafish, exhibiting the potential for monitoring lipid transport and metabolism processes.