bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of mid-season coach turnover on running match performance and match outcome in professional soccer players
Authors: Radzimiński Łukasz , Padrón-Cabo Alexis , Modric Toni , Andrzejewski Marcin , Versic Sime , Chmura Paweł , Sekulic Damir , Konefał Marek 
Published: June 2022

AbstractThe aim of this research was to examine the physical match performance and match outcome before and after coach turnover in professional soccer teams compared with a control group containing coaches working continuously for 3 consecutive seasons. Analysed data included 325 performances of teams led by dismissed coaches (DC), 313 of teams led by new coaches (NC), and 580 of teams led by unchanged coaches (UnC). Variables, such as average number of collected points, total distance (TD), total distance per minute (TD/min), high-speed running (HSR), sprinting and number of high-intensity runs (NHIR), were analysed in the last 15 games of DC and 15 matches of NC. These periods were divided into 3 blocks out of 5 matches (5-match blocks). NC collected a significantly higher number of points than DC (p = 0.015), whereas average points collected by UNC were significantly greater than DC (p < 0.001 and NC (p = 0.012). TD and TD/min for DC were significantly lower (p < 0.001) compared with both NC and UnC, whereas significant differences in HSR (p = 0.003) and NHIR (p = 0.03) were identified between DC and NC. The current study reported that mid-season coach turnover may result in short-term improvement in team results and physical match performance. However, this effect disappears after a period of approximately 5 games.
Genetic relationships and genome selection signatures between soybean cultivars from Brazil and United States after decades of breeding
Authors: Maldonado dos Santos João Vitor , Sant’Ana Gustavo Cesar , Wysmierski Philip Traldi , Todeschini Matheus Henrique , Garcia Alexandre , Meda Anderson Rotter 
Published: June 2022

AbstractSoybean is one of the most important crops worldwide. Brazil and the United States (US) are the world’s two biggest producers of this legume. The increase of publicly available DNA sequencing data as well as high-density genotyping data of multiple soybean germplasms has made it possible to understand the genetic relationships and identify genomics regions that underwent selection pressure during soy domestication and breeding. In this study, we analyzed the genetic relationships between Brazilian (N = 235) and US soybean cultivars (N = 675) released in different decades and screened for genomic signatures between Brazilian and US cultivars. The population structure analysis demonstrated that the Brazilian germplasm has a narrower genetic base than the US germplasm. The US cultivars were grouped according to maturity groups, while Brazilian cultivars were separated according to decade of release. We found 73 SNPs that differentiate Brazilian and US soybean germplasm. Maturity-associated SNPs showed high allelic frequency differences between Brazilian and US accessions. Other important loci were identified separating cultivars released before and after 1996 in Brazil. Our data showed important genomic regions under selection during decades of soybean breeding in Brazil and the US that should be targeted to adapt lines from different origins in these countries.
Relationship between orthostatic hypotension and recurrence of benign paroxysmal positional vertigo
Authors: Kim Moon Jung , Rhim Gu il 
Published: June 2022

AbstractBlood pressure is maintained by a combined mechanism of the baroreceptor reflex and the vestibulosympathetic reflex. This study is intended to verify the hypothesis that the orthostatic hypotension (OH) seen when benign paroxysmal positional vertigo (BPPV) occurred may act as a factor that affects the recurrence of BPPV. The subjects of present study were selected from among 239 patients diagnosed with idiopathic BPPV. The average age of the group with OH was 59.3 years, and the age of the group without OH was 50.3 years, with a statistically significant difference (P = 0.013). It was shown that drug-taking increased the risk of OH occurrence by 4.08 times (C.I for exp(B): 1.20–13.77) compared to the group that did not take drugs. It was shown that the risk of recurrence of BPPV was significantly reduced in the no recurrence group compared to the multiple recurrence group when there was no OH (p = 0.000; aOR 0.0000002). Also, the risk of recurrence was significantly reduced in the no recurrence group compared to the multiple recurrence group when there was no drug-taking (p = 0.000 aOR 0.0000001). This study is the first study that studied the effect of OH on the recurrence of BPPV and showed the possibility that OH could partially influence the recurrence of BPPV.
Deletions on 9p21 are associated with worse outcomes after anti-PD-1/PD-L1 monotherapy but not chemoimmunotherapy
Authors: Ebot Ericka M. , Duncan Daniel L. , Tolba Khaled , Fabrizio David , Frampton Garrett M. , Comment Leah A. , Albacker Lee A. 
Published: June 2022

AbstractNCCN guidelines for first-line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) patients without targetable driver alterations includes either immunotherapy alone or in combination with chemotherapy. In this study, we investigated genomic predictors of survival after immunotherapy to guide this treatment decision. Cox proportional hazards regression was used to identify genomic correlates of survival in a cohort of EGFR/ALK-, non-squamous NSCLC patients treated with first-line pembrolizumab monotherapy (mono-IO) or pembrolizumab in combination with carboplatin/cisplatin and pemetrexed (chemo-IO) within a real-world clinico-genomic database. The effect of deletions on 9p21 was further evaluated in five additional tumor types. Among mono-IO treated non-squamous NSCLC patients, tumors with 9p21.3 gene deletions (CDKN2A, CDKN2B, MTAP) were associated with worse survival compared to the corresponding deletion-negative tumors (CDKN2A deletion HR = 1.8, P = 0.001). However, this association was not observed among chemo-IO treated patients (CDKN2A deletion HR = 1.1, P = 0.4). This finding remained after adjusting for clinical and genomic features including TMB and PD-L1. Deletions at 9p21.3 were not associated with differences in TMB, PD-L1, or tumor inflammation. Due to the high incidence of 9p21.3 deletions across tumor types, we performed a pan-cancer analysis and found CDKN2A deletion-positive tumors had worse survival following first-line immunotherapy treatment in multiple tumor types (HR = 1.4, P < 0.001). These results indicate deletions at 9p21.3 are a putative negative predictor of clinical benefit from first-line immune checkpoint inhibitors and may have utility in choosing between mono-IO vs chemo-IO regimens in NSCLC.
Exploration of sub-bandgap states in 2D halide perovskite single-crystal photodetector
Authors: Choi Eunyoung , Zhang Yurou , Soufiani Arman Mahboubi , Lee Minwoo , Webster Richard F. , Pollard Michael E. , Reece Peter J. , Lee Wonjong , Seidel Jan , Lim Jongchul , Yun Jung-Ho , Yun Jae Sung 
Published: June 2022

AbstractGreater stability of low-dimensional halide perovskites as opposed to their three-dimensional counterparts, alongside their high extinction coefficient and thus excellent emission properties, have made them popular candidates for optoelectronic applications. Topological edges are found in two-dimensional perovskites that show distinct electronic properties. In this work, using Kelvin Probe Force Microscopy, performed on butylammonium lead bromide (BA2PbBr4) single crystals with optical bandgap of ~413 nm, we elucidate the electronic response of the edges and their potential impact on photodetector devices. We show that the charge-carriers are accumulated at the edges, increasing with the edge height. Wavelength-dependent surface photovoltage (SPV) measurements reveal that multiple sub-bandgap states exist in BA2PbBr4. As the edge height increases, the SPV amplitude at the edges reduces slightly more as compared to the adjacent regions, known as terraces, indicating relatively less reduction in band-bending at the surface due possibly to increased de-population of electrons from sub-bandgap states in the upper bandgap half. The existence of sub-bandgap states is further confirmed by the observation of below-bandgap emission (absorption) peaks characterised by spectral photoluminescence and photothermal deflection spectroscopy measurements. Finally, we fabricated a photodetector using a millimetre size BA2PbBr4 single crystal. Noticeable broadband photodetection response was observed in the sub-bandgap regions under green and red illumination, which is attributed to the existence of sub-bandgap states. Our observations suggest edge-height dependence of charge-carrier behaviour in BA2PbBr4 single crystals, a potential pathway that can be exploited for efficient broadband photodetector fabrication.
Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit
Authors: Molina-Granada David , González-Vioque Emiliano , Dibley Marris G. , Cabrera-Pérez Raquel , Vallbona-Garcia Antoni , Torres-Torronteras Javier , Sazanov Leonid A. , Ryan Michael T. , Cámara Yolanda , Martí Ramon 
Published: June 2022

AbstractImbalanced mitochondrial dNTP pools are known players in the pathogenesis of multiple human diseases. Here we show that, even under physiological conditions, dGTP is largely overrepresented among other dNTPs in mitochondria of mouse tissues and human cultured cells. In addition, a vast majority of mitochondrial dGTP is tightly bound to NDUFA10, an accessory subunit of complex I of the mitochondrial respiratory chain. NDUFA10 shares a deoxyribonucleoside kinase (dNK) domain with deoxyribonucleoside kinases in the nucleotide salvage pathway, though no specific function beyond stabilizing the complex I holoenzyme has been described for this subunit. We mutated the dNK domain of NDUFA10 in human HEK-293T cells while preserving complex I assembly and activity. The NDUFA10E160A/R161Ashows reduced dGTP binding capacity in vitro and leads to a 50% reduction in mitochondrial dGTP content, proving that most dGTP is directly bound to the dNK domain of NDUFA10. This interaction may represent a hitherto unknown mechanism regulating mitochondrial dNTP availability and linking oxidative metabolism to DNA maintenance.
Gain-switching in CsPbBr3 microwire lasers
Authors: Tian Jiao , Weng Guoen , Liu Yuejun , Chen Shengjie , Cao Fuyi , Zhao Chunhu , Hu Xiaobo , Luo Xianjia , Chu Junhao , Akiyama Hidefumi , Chen Shaoqiang 
Published: June 2022

AbstractAll-inorganic perovskite microwire lasers, which have intrinsic high material gain and short cavity, especially favor the generation of ultrashort optical pulses via gain switching for various potential applications. Particularly, the ultrashort gain-switched pulses may extend perovskite microwires to previously inaccessible areas, such as ultrafast switches, and chipscale microcombs pumping souces in photonic integrated circuits. Here, we show 13.6-ps ultrashort single-mode green pulses from the gain-switched CsPbBr3 microwire lasers under femtosecond optical pumping. The gain-switching dynamics is experimentally investigated by a streak camera system. The excitation fluence dependences of pulse width, delay time and rise time of the output pulses show good agreements with the rate equation simulations with taking gain nonlinearities and carrier recombination ABC model into account. Our results reveal that perovskite microwire lasers have potential for ultrashort pulse generation, while the low transient saturated gain, which may result from the high transient carrier temperature under femtosecond pumping is a significant limitation for further pulse shortening.
Very massive star winds as sources of the short-lived radioactive isotope 26Al
Authors: Martinet Sébastien , Meynet Georges , Nandal Devesh , Ekström Sylvia , Georgy Cyril , Haemmerlé Lionel , Hirschi Raphael , Yusof Norhasliza , Gounelle Matthieu , Dwarkadas Vikram 
Published: June 2022

Context. The 26Al short-lived radioactive nuclide is the source of the observed galactic diffuse γ-ray emission at 1.8 MeV. While different sources of 26Al have been explored, such as asymptotic giant branch stars, massive stellar winds, and supernovae, the contribution of very massive stars has not been studied so far.
Aims. We study the contribution of the stellar wind of very massive stars, here, stars with initial masses between 150 and 300 M⊙, to the enrichment in 26Al of the galactic interstellar medium.
Methods. We studied the production of 26Al by studying rotating and non-rotating very massive stellar models with initial masses between 150 and 300 M⊙ for metallicities Z = 0.006, 0.014, and 0.020. We compared this result to a simple Milky Way model and took the metallicity and the star formation rate gradients into account.
Results. We obtain that very massive stars in the Z = 0.006 − 0.020 metallicity range might be very significant contributors to the 26Al enrichment of the interstellar medium. Typically, the contribution of the winds of massive stars to the total quantity of 26Al in the Galaxy increases by 150% when very massive stars are considered.
Conclusions. Despite their rarity, very massive stars might be important contributors to 26Al and might overall be very important actors for nucleosynthesis in the Galaxy.
Unravelling UBC 274: A morphological, kinematical, and chemical analysis of a disrupting open cluster
Authors: Casamiquela L. , Olivares J. , Tarricq Y. , Ferrone S. , Soubiran C. , Jofré P. , di Matteo P. , Espinoza-Rojas F. , Castro-Ginard A. , de Brito Silva D. , Chanamé J. 
Published: June 2022

Context.Open clusters in the process of disruption help to understand the formation and evolution of the Galactic disk. The wealth and homogeneity ofGaiadata have led to the discovery of several open clusters with signs of disruption. Detailed chemical information for these clusters is essential in order to study the timescales and interplay between the star formation process and cluster disruption.Aims.We perform a morphological, kinematic, and chemical analysis of the disrupting cluster UBC 274 (2.5 Gyr,d = 1778 pc), to study its global properties.Methods.We use HDBSCAN to obtain a new membership list up to 50 pc from its centre and up to magnitudeG = 19 usingGaiaEDR3 data. We use high-resolution and high signal-to-noise spectra to obtain atmospheric parameters of six giants and sub-giants, and individual abundances of 18 chemical species.Results.The cluster has a highly eccentric (0.93) component, tilted ∼10 deg with respect to the plane of the Galaxy, which is morphologically compatible with the results of a test-particle simulation of a disrupting cluster. Our abundance analysis shows that the cluster has a sub-solar metallicity of [Fe/H] = −0.08 ± 0.02. Its chemical pattern is compatible with that of Ruprecht 147, of similar age but located closer to the Sun, with the remarkable exception of neutron-capture elements, which present an overabundance of [n/Fe] ∼ 0.1.Conclusions.The cluster’s elongated morphology is associated with the internal part of its tidal tail, following the expected dynamical process of disruption. We find a significant sign of mass segregation, where the most massive stars appear 1.5 times more concentrated than other stars. The cluster’s overabundance of neutron-capture elements can be related to the metallicity dependence of the neutron-capture yields due to the secondary nature of these elements, predicted by some models. UBC 274 presents a high chemical homogeneity at the level of 0.03 dex in the sampled region of its tidal tails.
Resuscitation of Term Compromised and Asphyctic Newborns: Better with Intact Umbilical Cord?
Authors: Ott Friederike , Kribs Angela , Stelzl Patrick , Kyvernitakis Ioannis , Ehlen Michael , Schmidtke Susanne , Rawnaq-Möllers Tamina , Rath Werner , Berger Richard , Maul Holger 
Published: June 2022

AbstractThe authors hypothesize that particularly severely compromised and asphyctic term infants in need of resuscitation may benefit from delayed umbilical cord clamping (after several minutes).
Although evidence is sparse, the underlying pathophysiological mechanisms support this assumption. For this review the authors have analyzed the available research. Based on these data they
conclude that it may be unfavorable to immediately clamp the cord of asphyctic newborns (e.g., after shoulder dystocia) although recommended in current guidelines to provide quick
neonatological support. Compression of the umbilical cord or thorax obstructs venous flow to the fetus more than arterial flow to the placenta. The fetus is consequently cut off from a
supply of oxygenated, venous blood. This may cause not only hypoxemia and consecutive hypoxia during delivery but possibly also hypovolemia. Immediate cord clamping may aggravate the
situation of the already compromised newborn, particularly if the cord is cut before the lungs are ventilated. By contrast, delayed cord clamping leads to fetoplacental transfusion of
oxygenated venous blood, which may buffer an existing acidosis. Furthermore, it may enhance blood volume by up to 20%, leading to higher levels of various blood components, such as red and
white blood cells, thrombocytes, mesenchymal stem cells, immunoglobulins, and iron. In addition, the resulting increase in pulmonary perfusion may compensate for an existing hypoxemia or
hypoxia. Early cord clamping before lung perfusion reduces the preload of the left ventricle and hinders the establishment of sufficient circulation. Animal models and clinical trials
support this opinion. The authors raise the question whether it would be better to resuscitate compromised newborns with intact umbilical cords. Obstetric and neonatal teams need to work
even closer together to improve neonatal outcomes.
Interdisziplinäres Teamtraining
Authors: Klotzsch Anne-Katrin 
Published: June 2022

Simulationsbasiertes Üben für kritische Notfälle in der
GeburtshilfeNotfälle in der Geburtshilfe führen bei den
betroffenen Eltern und dem Neugeborenen meist zu einer starken physischen und
psychischen Belastung. Neben der Beachtung von Leitlinien und effektiven
Handlungsalgorithmen eignet sich vor allem das Simulationstraining, um die
Notfälle primär zu vermeiden und/oder einen unvorhersehbaren
Notfall optimal zu versorgen.
Der Genius von NRF2
Authors: Barring Robert , Gröber Uwe 
Published: June 2022

ZusammenfassungNuclear factor erythroid-2-related factor 2 (NRF2) ist ein Transkriptionsfaktor,
der über 500 Gene im humanen Genom reguliert. Durch Aktivierung von
Antioxidant-Response-Element-Genen im Zellkern werden Zellschutz- und
Entgiftungseffekte ausgelöst. NRF2 schützt u. a. vor
oxidativem/nitrosativem Stress, Silent Inflammation und
Mitochondriopathie. Positive Effekte sind z. B. bei Herz-, Autoimmun-
und neurodegenerativen Erkrankungen, aber auch bei Sepsis und chronischer
Virusaktivierung zu beobachten. NRF2-aktivierende Substanzen wie Karotinoide,
langkettige ω-3-Fettsäuren und sekundäre Pflanzenstoffe
finden sich in mediterraner und Okinawa-Ernährung. Der Einsatz von
Konzentraten in Kapselform führte bei Patient*innen zur
Besserung der klinischen Symptomatik und von Laborwerten.
Arthroscopic Hemitrapezectomy and Suspension with Mini TightRope for the Treatment of Rhizarthrosis: Outcome in patients in stages Eaton-Littler 2 to 3
Authors: Jorquera René , Orellana Pablo , Melibosky Francisco , Paz Eduardo , Liendo Rodrigo , Azócar Camila 
Published: June 2022

Abstract
Introduction Rhizarthrosis is a common cause of pain and impaired function of the hand. Most patients present an excellent response to the conservative treatment, although a small percentage requires a surgical procedure due to the persistence of symptoms. Different surgical procedures have been described; however, there is still no consensus in the literature regarding the superiority of one technique over the others.
Objective To evaluate the clinical and radiological results of patients with a diagnosis of rhizarthrosis in stages 2 to 3 of the Eaton-Littler classification, submitted to arthroscopic hemitrapezectomy and suspension with Mini TightRope (Arthrex, Naples, FL, US).
Materials and methods We conducted a retrospective evaluation of the clinical and radiological results of patients operated on through the technique proposed in Clínica INDISA, in Santiago, Chile, between 2017 and 2019. The pre- and postsurgical assessments were performed using the visual analog scale (VAS) for pain, the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, and the Kapandji score. The state of the articular cartilage was also evaluated intraoperatively according to the Badia classification.
Results A total of 12 patients (3 men and 9 women) met the inclusion criteria. Their mean age was 56 years, the mean duration of the follow-up was of 21 months. There were 7 patients in stage 2 and 5 in stage 3 according to the Eaton-Littler classification. Intraoperatively, there were 6 patients in stage II and 6 in stage III of the Badia classification. The mean preoperative score on the Kapandji index was of 3.6, and the mean postoperative score was of 9. The mean preoperative score on the VAS was of 8.8, and the mean postoperative score was of 1.2. The mean preoperative score on the DASH was of 33.3, and the mean postoperative score was of 4.7.
Conclusion Arthroscopic and suspension hemitrapezectomy with Mini TightRope for the treatment of stage 2-3 rhizarthrosis is a minimally-invasive, reproducible technique, effective in reducing pain and improving function, with sustained effects on the short and middle terms (6 to 36 months).
Acrometastases to the Hand and Wrist: A Series of 9 Cases and Review of the Literature
Authors: Valverde-Vilamala D. , Sala-Pujals A. , Cebamanos J. , Dominguez-Font E. 
Published: June 2022

Abstract
Introduction Acrometastases are extremely rare in the hand, with a prevalence of around 0.1% according to the literature. They are normally associated with advanced tumor stages, especially in lung cancer. The present article shows the experience of our center in the management and treatment of these pathologies.
Materials and Methods We report a series of 9 cases treated between 1992 and 2020 in the hand and wrist. Data regarding the primary tumor, the target organ, and survival are analyzed. A review of the cases of acrometastasis reported in the literature is also carried out, emphasizing in how many of then the acral lesion was the first sign of an unknown tumor.
Results Acrometastases predominantly affect male patients aged around 60 years, and the primary tumor that is the cause in most cases is lung cancer, with a very low survival rate after the diagnosis (of approximately 8 months).
Discussion and Conclusions In cases of acral lesion of non-traumatic origin, acrometastases should be considered, especially in patients who have a known primary tumor. In the present series, there were three cases in which the acrometastases were the first sign of a tumor in the patient, and in one of them it was initially treated as whitlow. In the literature, in approximately 50% of the cases, acrometastases are the first sign of the presence of a tumor.Once diagnosed, multidisciplinary medicosurgical treatment is essential to improve the patient's function and pain as much as possible.
Rehabilitation in Triangular Fibrocartilage Complex Injuries: Treatment Algorithm
Authors: Lerma Eva Guisasola , Garcia Francisco Javier Lucas , Caraballo Alberto Márquez , Royo David Santosjuanes 
Published: June 2022

AbstractInjuries to the triangular fibrocartilage complex (TFCC) can lead to instability of the distal radioulnar joint (DRUJ). In fact, they are the most frequent cause of it. But, in other cases, depending on the type of injury, the DRUJ remains stable. This will condition different types of treatments, from conservative management to the different options of surgical treatment. Since a controversy persists regarding the management of these lesions, our purpose is to disclose the foundations of the rehabilitation treatment and propose an algorithm of treatment according to the different types of injuries and their repairs.