bluuebunny/crossref_metadata_2025_split huggingface dataset:
VIRMA Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Upregulation of E2F7 in an m6A-Dependent Manner
Authors: Zheng Zi-Qi , Huang Zhuo-Hui , Liang Ye-Lin , Zheng Wei-Hong , Xu Cheng , Li Zhi-Xuan , Liu Na , Yang Pan-Yang , Li Ying-Qin , Ma Jun , Sun Ying , Tang Ling-Long , Wei Denghui 
Published: September 2022

Abstract
The N6-methyladenosine (m6A) modification possesses new and essential roles in tumor initiation and progression by regulating mRNA biology. However, the role of aberrant m6A regulation in nasopharyngeal carcinoma (NPC) remains unclear. Here, through comprehensive analyses of NPC cohorts from the GEO database (GES12452, GSE12349, and GSE61218) and our internal cohort, we identified that VIRMA, an m6A writer, is significantly upregulated in NPC and plays an essential role in tumorigenesis and metastasis of NPC, both in vitro and in vivo. High VIRMA expression served as a prognostic biomarker and was associated with poor outcomes in patients with NPC. Mechanistically, VIRMA mediated the m6A methylation of E2F7 3′-UTR, then IGF2BP2 bound and maintained the stability of E2F7 mRNA. An integrative high-throughput sequencing approach revealed that E2F7 drives a unique transcriptome distinct from the classical E2F family in NPC, which functioned as an oncogenic transcriptional activator. E2F7 cooperated with CBFB-recruited RUNX1 in a non-canonical manner to transactivate ITGA2, ITGA5, and NTRK1, strengthening Akt signaling-induced tumor-promoting effect. These results together demonstrate the role of VIRMA as an m6A writer that modulates E2F7 expression to control the transcription program of NPC, unveiling an m6A modulator that is essential for NPC tumorigenesis and metastasis.
Identification of a novel ESR1 mutation in a Chinese PCOS woman with estrogen insensitivity in IVF treatment
Authors: Liu Faying , Tian Lifeng , Tan Jun , Li Zengming , Qin Haiyan , Xu Dingfei , Huang Zhihui , Wu Xingwu , Chen Ge , Wu Qiongfang , Zou Yang 
Published: September 2022

Abstract
Background: Polycystic ovary syndrome (PCOS) is a complex reproductive disorder, affecting approximately 5-10% of women of reproductive age. The complexity of the disease is contributed by genetic, lifestyle and environmental factors. Previous studies emphasized the important roles of estrogen receptors played in the pathogenesis of PCOS.Objective: To assess the possible pathogenic factors of a PCOS sample exhibited estrogen insensitivity during HRT treatment via whole exon sequencing (WES).Methods: Genome sequencing and variant filtering via WES was performed in the patient with PCOS. DNA extraction from 364 unrelated female controls without PCOS was followed by PCR amplification, Sanger sequencing and sequence alignment. Result(s): During controlled ovarian hyperstimulation (COH) regime in IVF cycle, the sample had a markedly prolonged ovarian stimulation period due to poor response to Gn and an elevated serum FSH. A novel ESR1 mutation leading to the replacement of a highly conserved alanine by threonine at the 207th residue was identified in this sample, via whole exome sequencing (WES) analysis. This novel variant was neither identified in 364 unrelated female controls without PCOS, nor in the EXAC and 1,000 genome project.Conclusion(s): We identified a novel heterozygous ESR1 mutation in a Han Chinese PCOS sample exhibiting clinical signs of estrogen insensitivity, for the first time. This study may disclose some new clues for the IVF therapy, especially for those samples who exhibited estrogen insensitivity in IVF cycle.
Effects of wall topology on statistics of cube-roughened wall turbulence
Authors: Li Shilong , Zhou Zhideng , Chen Danyang , Yuan Xianxu , Guo Qilong , Yang Xiaolei 
Published: September 2022

Abstract
In this work, we carried out roughness-resolved direct numerical simulations of cube-roughened turbulent channel flows to investigate the effects of aligned and staggered arrangements, element spacings, and element orientations on the statistics of rough-wall turbulence. The results show that the equivalent sandgrain roughness, Reynolds stresses and dispersive stresses are all affected by element spacings and arrangements, but in different ways depending on the cube orientations. Placing the roughness elements in a staggered way in general increases the equivalent sandgrain roughness, unless when the element-element interaction is insignificant for the cube orientation with wakes of short length. As for the Reynolds normal stresses and the streamwise component of the dispersive stresses (both are normalized by the total friction velocity), placing the cube elements in a staggered way decreases their maximal values when compared with the aligned arrangements. As for the effects of element spacing on the equivalent sandgrain roughness and the maximums of the Reynolds normal stresses, similar trends are observed for different element orientations and arrangements when increasing the element spacing l/r (where r is the cube width) from 2.0 to 2.8. When further increasing the element spacing l/r from 2.8 to 3.5, however, different trends are observed for different element orientations. As for the dispersive stresses, greater maximal values of their streamwise components are observed for larger element spacing for all the considered cube-roughened surfaces. For the turbulence statistics in the wake of the cube element, certain similarities are observed for different element spacings.
Geometric Kinematics for Urban Growth: A Theoretical Vector Field Framework
Authors: Kachroo Pushkin , Bhatia Samarth Y. , Patil Gopal R. 
Published: September 2022

Abstract
This paper presents a new approach and framework for the study of spatio-temporal geometric kinematics for urban growth built on deriving a vector field from the evolution of the shape as an inverse problem for the kinematics. Once we can compute the vector field, then the reason for the growth coming from socioeconomic and other factors can be related to the sources of the fields. This can make this concept very useful from a practical point of view. This paper presents the kinematic evolution of the shape that is derived by solving the inverse evolution problem using computational geometry. The solution of the problem allows for interpolation as well as extrapolation of the evolution. The paper developed the theory and algorithm for the evolution computational geometry and also shows how then various urban growth driving factors can be connected to the evolution parameters. We implemented the new algorithm and framework on a study area from Mumbai Metropolitan Region (MMR) in India where we had data available from three different years using remote sensing for the region growth as well as for urban growth factors from various sources. We solved the inverse computational geometry problem as well as built a relationship between the growth factors and growth rate using regression as demonstration of the concept.
Applications for mixed Chen-Lee-Liu derivative nonlinear Schrödinger equation in water wave flumes and optical fibers
Authors: Seadawy Aly R. , Ahmed Sarfaraz , Rizvi T. R. , Nazar Kashif 
Published: September 2022

Abstract
In this work, by applying the symbolic computation with ansatz functions approach and logarithmic transformation , we investigate the analytical rational solitons of the mixed Chen-Lee-Liu derivative nonlinear Schrödinger (MCLLNLS)-equation. We acquire two categories of M-shaped rational solutions and their dynamics are revealed in figures by choosing the proper vales of concerned parameters. Moreover two types of interaction of M-shaped rational solutions with kink wave are computed. Furthermore we evaluate multiwaves solutions, Homoclinic breather, kink cross-rational solutions and periodic cross-rational solutions for governing model. We also investigate the stability property of attained solutions and present in the form of table.
Hydrothermal converting quinonimine dye into pyrrolic-N for sustainable activated carbon regeneration
Authors: Wang Xiaonuan , Qian Yajie , Chen Hong , Li Xiang , Zhang Ai , Chen Changyu , He Yueling , Xue Gang 
Published: September 2022

Abstract

Activated carbon (AC) adsorption is a prevalent method for printing and dyeing wastewater (PDW) treatment, but restricted by adsorption active site depletion. The regeneration by thermal desorption or chemical oxidation is liable to destroy carbon structure as well as consume carbon composition, leading to few service cycles. Herein, we establish a sustainable hydrothermal regeneration for methylene blue (MB) exhausted AC. The absorbed MB was converted to its pyrrolic-N-containing hydrochar attached on regenerated AC, supporting 11 adsorption-regeneration cycles caused by the property shift from physical to chemical adsorption. Meanwhile, pyrrolic-N could reduce Cr(VI) to Cr(III) over a wide pH range of 3.0-9.0 via direct electron donation, and enabled recycling final regenerated AC once more. This approach is tailored to the dyes with the same quinonimine group as MB. So, the carbon capture for the simultaneous removal of dye and Cr(VI) in PDW can be implemented, while providing a novel green methodology to fabricate pyrrolic-N-loaded carbon material.
Tomato Transplant Research Workshop Held in Georgia
Authors: Jaworski C. A. , McCarter S. M. , Webb R. E. 
Published: September 2022

Abstract
The Fourth Annual Tomato Transplant Research Workshop was held at the Georgia Coastal Plain Experiment Station, Tifton, Georgia, on December 1, 1966. The 52 participants came from 11 states and the District of Columbia, and represented various areas of research, production (canning industry and transplant growers), extension, regulatory, and administration. The research participants included horticulturists, plant physiologists, geneticists, plant pathologists, nematologists, soil scientists, and agricultural engineers. The main topics discussed during the workshop were disease and nematode control, and management practices needed to facilitate mechanization of the transplant harvest.
Mineral Composition of Turfgrasses
Authors: Butler J. D. , Hodges T. K. 
Published: September 2022

Abstract
The mineral composition of grasses commonly used for turf has received little study. This is especially so for the micronutrient elements. Some data are available for grasses grown under pasture conditions (7), however, most of these grasses and their method of culture are quite different from turfgrasses. The paucity of information on turfgrasses prompted this survey of the mineral composition of several grasses commonly used for ornamental purposes. The grasses studied were grown in the field under a maintenance program typical of that used for turfgrasses. The results should be of value for future comparisons where nutrient toxicities, deficiencies or imbalances are suspected.
Stereoscan Electron Microscope1: A Useful Tool for Studying Plant Tissues2
Authors: Simons Roy K. 
Published: September 2022

Abstract
Evaluation of plant tissues with anatomical diversity has been a long, tedious process by the conventional methods for anatomical research. Severe treatment by chemicals and heat often destroy or distort the specimen to a point where it is rendered useless. Size and number of specimens to be evaluated has also been a limiting factor for processing in anatomical studies
A Rapid Method for Preparation of Plant Material for Paraffin Embedding1
Authors: Halfacre R. G. , Walton A. M. , Osborne J. C. 
Published: September 2022

Abstract
The standard method of preparing plant material by hand for histological study takes several days (1,2). A procedure is described herein which reduces processing time to 17 hours or less and provides tissues which are completely dehydrated and infiltrated. Up to 100 samples can be prepared within this time period. The method requires a minimum expenditure of time without sacrificing cytological detail.
Vegetable Seed Industry and Government Cooperation in Research in the USA
Authors: Boswell Victor R. 
Published: September 2022

Abstract
We believe it is vital that the scientists of our public research agencies really know and understand at first hand the problems of the seed and vegetable industries they are called upon to serve. We need to visit our seedsmen on their home grounds, and learn of their troubles, their successes, ideas, and practices. It is no less important for our seedsmen to know us, how we work, what we think, and what we can do—or cannot do—in their field of interest. Such mutual understandings have led, over the years, to some highly effective and satisfying cooperative relationships between our government agencies and our vegetable seed industry. Our respective backgrounds and experiences complement each other. We have developed a mutual trust and an appreciation of our interdependence in accomplishing our respective objectives. We, in government, know that industry know-how and collaboration have contributed enormously to the success of our ultimate objectives in research. And we trust that the benefits are mutual.
Withholding Phosphorus as a Conservation Measure for Vegetable Plants
Authors: Kohl Harry C. , Nelson R. L. 
Published: September 2022

Abstract
Two experiments were conducted to test the hypothesis that plants in the vegetative state would not succumb as rapidly to low light intensities if they had no phosphorous available as the resulting restriction in growth would permit stored photosynthate to be available for plant maintenance. The first used Peperomia obtusifolia ‘Variegata’ as the test plant. The rooted cuttings were received on December 22, 1965, and potted in propagator’s sand. They were grown in sand cultures to the surface of which a mineral nutrient solution was applied daily with the leachate allowed to drain away. The mineral nutrient solution contained in millimoles per liter, 5, 6, 1, and 1 of Ca(NO3)2, KNO3, KH2PO4, and Mg-SO4, respectively. Two ppm of Fe were added as a chelate (Fe 138) and trace elements were added as usual for a solution culture according to the recipe of Hoagland.
What Accreditation Has Meant to Landscape Architecture
Authors: Osmundson Theodore 
Published: September 2022

Abstract
Eight years ago I became a member of the Committee on Education of the American Society of Landscape Architects which is the accreditating body for the profession of landscape architecture. I served on that Committee for four years and went on a number of accrediting visits to various schools of landscape architecture. During the last four years I have engaged in other activities for the Society, but one of the most important was the study of the Committee on Education itself with a view toward improving its functions and to relieve some of the criticisms which were coming from various schools throughout the country. So I am quite familiar with accreditation in this field and am extremely interested in it. I feel that this is one of the most important activities in which the AS LA is involved today — the improvement of education.
Effect of Cytokinins on Apple Shoot Development from Axillary Buds
Authors: Williams Max W. , Stahly E. A. 
Published: September 2022

Abstract
Cytokinins applied to axillary buds of apple shoots overcame apical dominance. Axillary buds on actively growing apple shoots produced spurs and lateral branches when treated with cytokinins. Buds on shoots that had not received sufficient chilling to break rest were also induced to grow with cytokinins.
The Effect of Depth of Planting on the Survival, Yield, and Spread of the Common Lowbush Blueberry Vacciniiim angnstifolium Ait1
Authors: Aalders Lewis E. , Hall Ivan V. 
Published: September 2022

Abstract
One-year old lowbush blueberryplants from 6 clonal lines were set in the field in May, 1964 at 3 planting depths: shallow (top of pot level with soil), medium (approximately 7 cm deeper than shallow), and deep (approximately 14 cm deeper than shallow). The shallow plants heaved an average of 2.19 cm the first winter, but there was no mortality due to desiccation injury as experienced in previous work. Plants at the medium and deep planting depths heaved very little. Forty-four of 72 plants at the deepest planting depth died as a result of burying. The shallow and medium plants had the greatest spread 2 years after planting, but suffered the most from burn pruning. The deep set plants had the greatest growth increment during the third and fourth years after planting, and as a result, the medium and deep plantings had the greatest spread after 4 years. The shallow and medium plants had the greatest fruit yield in 1965, but in 1967, the medium and deep plants had the greatest fruit yield. It is concluded that the medium planting depth is the most satisfactory of the 3 depths at which to set lowbush blueberries.
Photoperiod, Indolebutyric Acid, and Type of Cutting Wood as Factors in the Rooting of Rabbiteye Blueberry (Vacamum asbei Reade), cv. Woodward1
Authors: Couvillon G. A. , Pokorny F. A. 
Published: September 2022

Abstract
The rabbiteye blueberry, V. ashei, is planted to a limited extent in the Southeast, although it is adapted to an area extending from Virginia to Texas. The difficulty in propagating the species is one factor limiting the planting of improved selections (1). Many factors are known to influence root initiation and development in cuttings of rabbiteve, lowbush, and highbush blueberry species (2,4,5,7,8,9,10), but the effect of extended photoperiods on the rooting of the rabbiteye species is lacking. This study was conducted in 1963 and 1964 to investigate the effect of photoperiod and IBA on the rooting of cuttings of the rabbiteye blueberry, ‘Woodard’.
A Simple Technique for Identification of Floral Development in Tulipa sp1
Authors: De Hertogh A. A. , Aung Louis H. 
Published: September 2022

Abstract
It has been demonstrated that flower induction and differentiation in the tulip occurs long before flowering takes place in the spring (1, 2). In the Northern Hemisphere, the initiation of floral primordia begins soon after the bulbs are harvested from the fields in late June or early July and normally, differentiation of the floral parts is completed by late August or early September. By determining the effect of various post-harvest storage temperatures on the development of the floral parts, Luyten et al. (2) showed that the optimal temperature range for flower initiation and development is 17 to 20°C. During the course of these studies, it was observed that the apical meristem passed through seven well-defined phases of development. They were designated by use of the Roman numerals I through VII. Later, Beyer (3) reclassified these stages using alphabetical letters and subscripts selected to correspond to the morphological stages of development e.g. “P1” to indicate the first outer whorl of perianth. Beyer’s “G” stage is comparable to Blaauw’s stage VII (Figure 1). The two designations have been used interchangeably in the literature.
Influence of Sodium in Mist Water on Rooting of Chrysanthemums
Authors: Paul J. L. , Leiser A. T. 
Published: September 2022

Abstract
An aspect of mist propagation which may be important in rooting cuttings is the quality of water used in misting. This may be particularly important in arid regions where many waters contain significant concentrations of salts. Although waters have been classified (1) for general irrigation purposes on the basis of total salts, sodium rating, boron concentration, etc., the propagator sometimes overlooks these properties of his mist water.
Characteristics and Propagation of Rootstocks for Deciduous Fruits in the North Central Region, 1966-67
Authors: Simons R. K. , Carlson R. F. 
Published: September 2022

Abstract
The North Central Regional Committee “Stock Scion Relationships in Horticultural Plants” (NC 78) undertook, in 1966-67, a survey of rootstock production of deciduous fruits. The committee representative from each state ! contacted the nurserymen of his own state1. These data have been compiled for the purpose of implementing and coordinating future research concerning the problems of stock-scion relationships such as incompatibilities and failure of anticipated tree and fruit responses under different climatic and environmental conditions.
The Challenging Situation in Developing Superior Fruit Cultivars
Authors: Spangelo Lloyd P. S. 
Published: September 2022

Abstract
It is apparent that many regard fruit crops like the apple, peach, pear, raspberry and strawberry as luxury crops, their value being largely that of providing variety rather than the basic dietary needs. In a period when emphasis is placed on the need for greater production of the basic foods, surely we must be concerned about, and be certain that, our research objectives are realistic.
Collecting Wild Fruits in the U.S.S.R.
Authors: Brooks Howard J. 
Published: September 2022

Abstract
Under the auspices of the Agreement Between the United States of America and the Union of Soviet Socialist Republics on Exchanges in the Scientific, Technical, Educational, Cultural, and Other Fields in 1966-67, I collected wild fruits in the Union of Soviet Socialist Republics in the summer of 1967. I travelled with Dr. Willis Skrdla, Research Agronomist, U.S. Regional Plant Introduction Station, Ames, Iowa, who collected seed of legume and forage crops. We arrived in Moscow August 15 and departed October 1.
Vernalization in Easter Lilies ?
Authors: Langhans R. W. , Weiler T. C. 
Published: September 2022

Abstract
Since Derek Smith (23) in 1963 used the term vernalization to describe the cold storage requirement of Easter lilies, the appropriateness of the term periodically has been questioned. Even among those who now accept this terminology, differences of opinion have arisen in interpretation of past and current experimental results. It is with this in mind we wish to clarify our reasons for enthusiastically accepting the vernalization concept for Easter lilies.
Use of Benzimidazoles for Control of Fungi in Peel Cultures of Citrus Fruits1
Authors: Oberbacher M. F. , Brown G. Eldon 
Published: September 2022

Abstract
Growth of fungi from the surface of excised peel taken from Florida citrus fruit interfered with controlled studies on pigment changes of the flavedo. Control of these fungi was not achieved even though whole fruits were dipped in various concentrations of sodium hypochlorite before removing discs of peel for incubation in culture on a defined medium (5). Normally, the presence of fungal growth was evident on all discs of excised peel after 3 to 5 days incubation at 30°C. Development of a technique to control these fungi was necessary to allow longer incubation of discs to observe pigment changes.
Effect of Growth Regulators on Time of Flowering of a Photoperiodic Sensitive Field Bean (Phaseolus vulgaris L.)
Authors: Coyne Dermot P. 
Published: September 2022

Abstract
The effect of CCC, B-9 and Gibberellin A-7 on time of flowering and the node of the first flower of the short-day Great Northern Nebraska No. 1 sel. 27 dry bean line under short and long photoperiods was investigated in the greenhouse. CCC was the only chemical which promoted early flowering under long photoperiods. Under long photoperiods, B-9 caused the first flower to open at higher nodes. The possible usefulness of these findings is discussed.
Control of Vegetative and Reproductive Development in Seed Plants1
Authors: Sachs R. M. , Hackett W. P. 
Published: September 2022

Abstract
Although for an entire plant, vegetative and reproductive development may proceed concurrently, at each shoot apical meristem a transition occurs from leaf production to bract or sepal production at the time of flower initiation. Subsequent stages of reproductive development are equally differentiated from that of vegetative development. Hence, vegetative and reproductive development represent alternative courses of differentiation of apical meristematic tissues.