bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grounded Normative Theory and Intersectional Differences
Authors: Behl Natasha 
Published: January 2022

Abstract
This article focuses on the promise of grounded normative theory in Luis Cabrera’s The Humble Cosmopolitan. The article celebrates Cabrera’s use of grounded normative theory as a way to center the lived experience of politically marginalized groups while also being attentive to the politics of knowledge production. My concern is not with the methodology itself; rather, it is with Cabrera’s partial use of it. I ask, how might the analysis of the book change if the author considered different intellectual histories of citizenship rooted in feminist and critical approaches? How might the theoretical assumptions and justifications of the book change if the author challenged his own assumptions, especially as they relate to the epistemic authority of Dalit women?
Safety of Cochlear Implantation in Children 12 Months or Younger: Systematic Review and Meta‐analysis
Authors: Sbeih Firas , Bouzaher Malek H. , Appachi Swathi , Schwartz Seth , Cohen Michael S. , Carvalho Daniela , Yoon Patricia , Liu Yi‐Chun Carol , Anne Samantha 
Published: January 2022

ObjectiveTo systematically review the literature to determine safety of cochlear implantation in pediatric patients 12 months and younger.Data SourceOvid MEDLINE, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched from inception to March 20, 2021.Review MethodsStudies that involved patients 12 months and younger with report of intraoperative or postoperative complication outcomes were included. Studies selected were reviewed for complications, explants, readmissions, and prolonged hospitalizations. Two independent reviewers screened all studies that were selected for the systematic review and meta‐analysis. All studies included were assessed for quality and risk of bias.ResultsThe literature search yielded 269 studies, of which 53 studies underwent full‐text screening, and 18 studies were selected for the systematic review and meta‐analysis. A total of 449 patients and 625 cochlear implants were assessed. Across all included studies, major complications were noted in 3.1% of patients (95% CI, 0.8‐7.1) and 2.3% of cochlear implantations (95% CI, 0.6‐5.2), whereas minor complications were noted in 2.4% of patients (95% CI, 0.4‐6.0) and 1.8% of cochlear implantations (95% CI, 0.4‐4.3). There were no anesthetic complications reported across all included studies.ConclusionThe results of this systematic review and meta‐analysis suggest that cochlear implantation in patients 12 months and younger is safe with similar rates of complications to older cohorts.
Transcriptomic analysis of the maize inbred line Chang7-2 and a large-grain mutant tc19
Authors: Zhang Yanrong , Jiao Fuchao , Li Jun , Pei Yuhe , Zhao Meiai , Song Xiyun , Guo Xinmei 
Published: January 2022

Abstract
Backgrounds
Grain size is a key factor in crop yield that gradually develops after pollination. However, few studies have reported gene expression patterns in maize grain development using large-grain mutants. To investigate the developmental mechanisms of grain size, we analyzed a large-grain mutant, named tc19, at the morphological and transcriptome level at five stages corresponding to days after pollination (DAP).

Results
After maturation, the grain length, width, and thickness in tc19 were greater than that in Chang7-2 (control) and increased by 3.57, 8.80, and 3.88%, respectively. Further analysis showed that grain width and 100-kernel weight in tc19 was lower than in Chang7-2 at 14 and 21 DAP, but greater than that in Chang7-2 at 28 DAP, indicating that 21 to 28 DAP was the critical stage for kernel width and weight development. For all five stages, the concentrations of auxin and brassinosteroids were significantly higher in tc19 than in Chang7-2. Gibberellin was higher at 7, 14, and 21 DAP, and cytokinin was higher at 21 and 35 DAP, in tc19 than in Chang7-2. Through transcriptome analysis at 14, 21, and 28 DAP, we identified 2987, 2647 and 3209 differentially expressed genes (DEGs) between tc19 and Chang7-2. By using KEGG analysis, 556, 500 and 633 DEGs at 14, 21 and 28 DAP were pathway annotated, respectively, 77 of them are related to plant hormone signal transduction pathway. ARF3, AO2, DWF4 and XTH are higher expressed in tc19 than that in Chang7-2.

Conclusions
We found some DEGs in maize grain development by using Chang7-2 and a large-grain mutant tc19. These DEGs have potential application value in improving maize performance.
Environmental spreading of clinically relevant carbapenem-resistant gram-negative bacilli: the occurrence of blaKPC-or-NDM strains relates to local hospital activities
Authors: Pereira Alex Leite , de Oliveira Pâmela Maria , Faria-Junior Célio , Alves Everton Giovanni , de Castro e Caldo Lima Glaura Regina , da Costa Lamounier Thaís Alves , Haddad Rodrigo , de Araújo Wildo Navegantes 
Published: January 2022

Abstract
Background
Aquatic matrices impacted by sewage may shelter carbapenem-resistant (CR) Gram-negative bacilli (GNB) harboring resistance genes of public health concern. In this study, sewage treatment plants (STPs) servicing well-defined catchment areas were surveyed for the presence of CR-GNB bearing carbapenemase genes (blaKPC or blaNDM).

Results
A total of 325 CR-GNB were recovered from raw (RS) and treated (TS) sewage samples as well as from water body spots upstream (UW) and downstream (DW) from STPs. Klebsiella-Enterobacter (KE) group amounted to 116 isolates (35.7%). CR-KE isolates were recovered from TS, DW (35.7%) and RS samples (44.2%) (p = 0.001); but not from UW samples. KE isolates represented 65.8% of all blaKPC or blaNDM positive strains. The frequency of blaKPC-or-NDM strains was positively associated with the occurrence of district hospitals located near STPs, as well as with the number of hospitalizations and of sewer connections serviced by the STPs. blaKPC-or-NDM strains were recovered from ST samples in 7 out of 14 STPs, including four tertiary-level STPs; and from 6 out of 13 DW spots whose RS samples also had blaKPC-or-NDM strains.

Conclusions
Clinically relevant GNB bearing blaKPC-or-NDM resist sewage treatments and spread into environmental aquatic matrices mainly from STPs impacted by hospital activities.
Telerehabilitation of acute musculoskeletal multi-disorders: prospective, single-arm, interventional study
Authors: Costa Fabíola , Janela Dora , Molinos Maria , Lains Jorge , Francisco Gerard E. , Bento Virgílio , Dias Correia Fernando 
Published: January 2022

Abstract
Background
Acute musculoskeletal (MSK) pain is very common and associated with impaired productivity and high economic burden. Access to timely and personalized, evidence-based care is key to improve outcomes while reducing healthcare expenditure. Digital interventions can facilitate access and ensure care scalability.

Objective
Present the feasibility and results of a fully remote digital care program (DCP) for acute MSK conditions affecting several body areas.

Methods
Interventional single-arm study of individuals applying for digital care programs for acute MSK pain. Primary outcome was the mean change between baseline and end-of-program in self-reported Numerical Pain Rating Scale (NPRS) score and secondary outcomes were change in analgesic consumption, intention to undergo surgery, anxiety (GAD-7), depression (PHQ-9), fear-avoidance beliefs (FABQ-PA), work productivity (WPAI-GH) and engagement.

Results
Three hundred forty-three patients started the program, of which 300 (87.5%) completed the program. Latent growth curve analysis (LGCA) revealed that changes in NPRS between baseline and end-of-program were both statistically (p < 0.001) and clinically significant: 64.3% reduction (mean − 2.9 points). Marked improvements were also noted in all secondary outcomes: 82% reduction in medication intake, 63% reduction in surgery intent, 40% in fear-avoidance beliefs, 54% in anxiety, 58% in depression and 79% recovery in overall productivity. All outcomes had steeper improvements in the first 4 weeks, which paralleled higher engagement in this period (3.6 vs 3.2 overall weekly sessions, p < 0.001). Mean patient satisfaction score was 8.7/10 (SD 1.26).

Strengths and limitations
This is the first longitudinal study demonstrating the feasibility of a DCP for patients with acute MSK conditions involving several body areas. Major strengths of this study are the large sample size, the wide range of MSK conditions studied, the breadth of outcomes measured, and the very high retention rate and adherence level. The major limitation regards to the absence of a control group.

Conclusions
We observed very high completion and engagement rates, as well as clinically relevant changes in all health-related outcomes and productivity recovery. We believe this DCP holds great potential in the delivery of effective and scalable MSK care.

Trial registration
NCT, NCT04092946. Registered 17/09/2019;
Development of a blended emergent research training program for clinical nurses (part 1)
Authors: Chen Qirong , Li Zeen , Tang Siyuan , Zhou Chuyi , Castro Aimee R. , Jiang Shan , Huang Chongmei , Xiao Jinnan 
Published: January 2022

Abstract
Background
Nursing research training is important for improving the nursing research competencies of clinical nurses. Rigorous development of such training programs is crucial for ensuring the effectiveness of these research training programs. Therefore, the objectives of this study are: (1) to rigorously develop a blended emergent research training program for clinical nurses based on a needs assessment and related theoretical framework; and (2) to describe and discuss the uses and advantages of the ADDIE model (Analysis, Design, Development, Implementation, Evaluation) in the instructional design and potential benefits of the blended emergent teaching method.

Methods
This intervention development study was conducted in 2017, using a mixed-methods design. A theoretical framework of blended emergent teaching was constructed to provide theoretical guidance for the training program development. Nominal group technique was used to identify learners’ common needs and priorities. The ADDIE model (Analysis, Design, Development, Implementation, Evaluation) was followed to develop the research training program for clinical nurses based on the limitations of current nursing research training programs, the needs of clinical nurses, and the theoretical foundation of blended emergent teaching.

Results
Following the ADDIE model, a blended emergent research training program for clinical nurses to improve nursing research competence was developed based on the needs of clinical nurses and the theoretical framework of blended emergent teaching.

Conclusions
This study indicates that nominal group technique is an effective way to identify learners’ common needs and priorities, and that the ADDIE model is a valuable process model to guide the development of a blended emergent training program. Blended emergent teaching is a promising methodology for improving trainees’ learning initiative and educational outcomes. More empirical studies are needed to further evaluate blended emergent teaching to promote the development of related theories and practice in nursing education.
Determining levels of nurse burnout during the COVID-19 pandemic and Lebanon’s political and financial collapse
Authors: Clinton Michael , Bou-Karroum Karen , Doumit Myrna Abdullah , Richa Nathalie , Alameddine Mohamad 
Published: January 2022

Abstract
Background
The COVID-19 pandemic compounded political and financial pressures on the nursing workforce in Lebanon. The government resigned in October 2019 in response to the popular uprising that called for an end to corruption and economic mismanagement 5 months before the first COVID-19 case appeared in the country. The continuing crises and the added stress of COVID-19 has increased the risk of occupational burnout and turnover in the nursing workforce. Therefore, valid and reliable measurement is imperative to determine burnout levels, prioritize intervention, and inform evidence-based workforce policy and practice. The primary aim of the study was to delineate burnout levels and cut-points in a national sample of nurses to inform workforce policies and prioritize interventions.

Methods
Multidimensional and unidimensional Rasch analyses of burnout data collected from a national convenience sample of 457 hospital nurses 9–12 months after Lebanon’s political and economic collapse began. The data were collected in July–October 2020.

Results
Multidimensional Rasch analysis confirmed that the Copenhagen Burnout Inventory has three highly correlated unidimensional scales that measure personal burnout, work-related burnout, and client-related burnout. Except for a ceiling effect of ~ 2%, the three scales have excellent measurement properties. For each scale, Rasch rating scale analysis confirmed five statistically different nurse burnout levels. The mean personal burnout scores and work-related burnout scores (50.24, 51.11 respectively) were not higher than those reported in the international literature. However, the mean client-related burnout score of 50.3 was higher than reported for other countries. Compared with a baseline study conducted at the beginning of Lebanon’s political and economic crises, only client-related burnout scores were higher p. <.01.

Conclusions
The CBI scales are reliable and valid measures for monitoring nurse burnout in crises torn countries. Stakeholders can use the CBI scales to monitor nurse burnout and prioritize burnout interventions. Urgent action is needed to reduce levels of client-related burnout in Lebanon’s nursing workforce.
IgE is associated with exacerbations and lung function decline in COPD
Authors: Lommatzsch Marek , Speer Timotheus , Herr Christian , Jörres Rudolf A. , Watz Henrik , Müller Achim , Welte Tobias , Vogelmeier Claus F. , Bals Robert ,   for the COSYCONET study group
Published: January 2022

Abstract
Background
Both allergen-specific IgE and total IgE in serum play a major role in asthma. However, the role of IgE in chronic obstructive pulmonary disease (COPD) is poorly understood. It was the aim of this study to systematically analyze the relationship between serum IgE levels and disease characteristics in large COPD cohorts.

Methods
COSYCONET is a comprehensively characterized cohort of patients with COPD: total IgE and IgE specific to common aeroallergens were measured in serum of 2280 patients, and related to clinical characteristics of the patients. WISDOM is another large COPD population (2477 patients): this database contains the information whether total IgE in serum was elevated (≥ 100 IU/l) or normal in patients with COPD.

Results
Both in COSYCONET and WISDOM, total IgE was elevated (≥ 100 IU/l) in > 30% of the patients, higher in men than in women, and higher in currently than in not currently smoking men. In COSYCONET, total IgE was elevated in patients with a history of asthma and/or allergies. Men with at least one exacerbation in the last 12 months (50.6% of all men in COSYCONET) had higher median total IgE (71.3 IU/l) than men without exacerbations (48.3 IU/l): this difference was also observed in the subgroups of not currently smoking men and of men without a history of asthma. Surprisingly, a history of exacerbations did not impact on total IgE in women with COPD. Patients in the highest tertiles of total IgE (> 91.5 IU/ml, adjusted OR: 1.62, 95% CI 1.12–2.34) or allergen-specific IgE (> 0.19 IU/ml, adjusted OR: 2.15, 95% CI 1.32–3.51) were at risk of lung function decline (adjusted by: age, gender, body mass index, initial lung function, smoking status, history of asthma, history of allergy).

Conclusion
These data suggest that IgE may play a role in specific COPD subgroups. Clinical trials using antibodies targeting the IgE pathway (such as omalizumab), especially in men with recurrent exacerbations and elevated serum IgE, could elucidate potential therapeutic implications of our observations.
Explanatory models of post-traumatic stress disorder (PTSD) and depression among Afghan refugees in Norway
Authors: Brea Larios Dixie , Sandal Gro Mjeldheim , Guribye Eugene , Markova Valeria , Sam David Lackland 
Published: January 2022

Abstract
Background
The current situation in Afghanistan makes it likely that we are facing a new wave of Afghan refugees, warranting more knowledge about how to deal with mental health problems among them. This study aims to gain more knowledge on Explanatory Models (EM) of depression and post-traumatic stress disorders (PTSD) among Afghan refugees resettled in Norway.

Methods
We conducted six gender-separated, semi-structured focusgroup interviews based on vignettes with Afghan refugees (total N = 27). The vignettes described a fictional character with symptoms of either depression or PTSD symptoms in line with DSM-5 and ICD-10 criteria.

Results
The findings showed that EM varied with gender, age, generation, and migration stories. Participants suggested different potential causes, risk factors, and ways of managing symptoms of depression and PTSD depending on the context (e.g., in Norway vs. Afghanistan). In describing the causes of the depression/PTSD in the vignettes, females tended to emphasize domestic problems and gender issues while males focused more on acculturation challenges. The younger males discussed mostly traumatic experiences before and during flight as possible causes.

Conclusion
The practice of condensing a single set of EMs within a group may not only be analytically challenging in a time-pressed clinical setting but also misleading. Rather, we advocate asking empathic questions and roughly mapping individual refugee patients’ perceptions on causes and treatment as a better starting point for building trusting relationships and inviting patients to share and put into practice their expertise about their own lives.
Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate
Authors: Fan Yuan , Fu Yunxing , Zhou Yuhang , Liu Yu , Hao Baocheng , Shang Ruofeng 
Published: January 2022

Abstract
Background
Py-mulin is a new pleuromutilin derivative with potent antibacterial activities in vitro and in vivo, suggesting this compound may lead to a promising antibacterial drug after further development. The present study is aimed to evaluate the acute and subacute oral toxicity, and the genotoxicity with the standard Ames test according to standard protocols.

Methods
Acute oral toxicity of Py-mulin was determined using Kunming mice. The 28-day repeated dose oral toxicity study in SD rats was performed according to OECD guideline No. 407. The bacterial reverse mutation (Ames test) was carried out using four Salmonella typhimurium (S. typhimurium) strains TA97, TA98, TA100 and TA1535 with and without S9 metabolic activation.

Results
The LD50 values in acute oral toxicity were 2973 mg/kg (female mice) and 3891 mg/kg (male mice) calculated by the Bliss method. In subacute toxicity study, 50 mg/kg Py-mulin did not induce any abnormality in body weight, food consumption, clinical sign, hematology, clinical chemistry, organ weight, and histopathology in all of the treatment groups. However, high doses of Py-mulin (100 and 300 mg/kg) displayed slightly hepatotoxicity to female rats. Furthermore, Py-mulin did not significantly increase the number of revertant colonies of four standard S. typhimurium strains with the doses of 0.16–1000 μg/plate in the Ames study.

Conclusions
Based on our findings, our study provides some information for the safety profile of Py-mulin.
3D technologies for intangible cultural heritage preservation—literature review for selected databases
Authors: Skublewska-Paszkowska Maria , Milosz Marek , Powroznik Pawel , Lukasik Edyta 
Published: January 2022

Abstract
Conservation of cultural heritage is nowadays a very important aspect of our lives. Thanks to such legacy we gain knowledge about our ancestors, methods of production and ways of their life. The rapid development of 3D technology allows for more and more faithful reflection of this area of life. The rich cultural heritage, both tangible and intangible, can be preserved for future generations due to the use of advanced 3d technologies. They provide the means of documenting, recovering and presenting items of cultural heritage. Not only buildings or monuments are taken into account. An important aspect of our culture is intangible cultural heritage (ICH), including acting, crafting or storytelling, passed down from generation to generation. Due to the rapid development of civilisation and the migration of people, this type of culture is often forgotten. That is why the preservation of ICH is an important element of today world. The main aim of this study, on the basis of the gathered papers, is to identify: (1) the general state of use of 3D digital technologies in ICH; (2) the topics and themes discussed; (3) the technologies used in the study; (4) locations of research centres conducting such studies; and (5) the types of research carried out. The methodology consists of the following main steps: defining study questions, searching query development, selection of publications in Scopus, Web of Knowledge and IEEE Xplore, finally the study execution and the analysis of the obtained results. The results show that for ICH the most often used technologies are: 3D visualisation, 3D modelling, Augmented Reality, Virtual Reality and motion capture systems.
Evolution of the geological structure and mechanical properties due to the collision of multiple basement topographic highs in a forearc accretionary wedge: insights from numerical simulations
Authors: Miyakawa Ayumu , Noda Atsushi , Koge Hiroaki 
Published: January 2022

AbstractWe propose a conceptual geological model for the collision of multiple basement topographic highs (BTHs; e.g., seamounts, ridges, and horsts) with a forearc accretionary wedge. Even though there are many BTHs on an oceanic plate, there are few examples of modeling the collision of multiple BTHs. We conducted numerical simulations using the discrete element method to examine the effects of three BTH collisions with forearcs. The typical geological structure associated with a BTH collision was reproduced during the collision of the first BTH, and multiple BTH collisions create a cycle of formation of BTH collisional structures. Each BTH forces the basal décollement to move up to the roof décollement, and the roof décollement becomes inactive after the passage of the BTH, and then the décollement moves down to the base. As the active décollement position changes, the sequences of underthrust sediments and uplifted imbricate thrusts are sandwiched between the décollements and incorporated into the wedge. At a low horizontal compressive stress, a “shadow zone” is formed behind (i.e., seaward of) the BTH. When the next BTH collides, the horizontal compressive stress increases and tectonic compaction progresses, which reduce the porosity in the underthrust sediments. Heterogeneous evolution of the geological and porosity structure can generate a distinctive pore pressure pattern. The underthrust sediments retain fluid in the “shadow” of the BTH. Under the strong horizontal compressive stresses associated with the next BTH collision, pore pressure increases along with a rapid reduction of porosity in the underthrust sediments. The distinctive structural features observed in our model are comparable to the large faults in the Kumano transect of the Nankai Trough, Japan, where a splay fault branches from the plate boundary and there are old and active décollements. A low-velocity and high-pore-pressure zone is located at the bottom of the accretionary wedge and in front (i.e., landward) of the subducting ridge in the Kumano transect. This suggests that strong horizontal compressive stresses associated with the current BTH collision has increased the pore pressure within the underthrust sediments associated with previous BTHs.