bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Angiomyomatous Hamartoma of the Lymph Node
Authors: Short Emma , Burke Nadine , Cotton David , Clague Gavin , Soukias Jean-Marc , Dojcinov Stefan 
Published: January 2022

Abstract
Angiomyomatous hamartoma (AMH) of the lymph node is a rare, hamartomatous lesion which typically occurs in the inguinal and femoral regions. Although benign, it can clinically and radiologically cause a suspicion of malignancy. Due to its rarity, pathological diagnosis, particularly on small needle biopsies, may be challenging. We present the case of a 67-year-old male with AMH, with a summary of the published cases and discussion of the differential diagnoses.
Metaphor identification in cybersecurity texts: a lightweight linguistic approach
Authors: Hilton Kelsey , Siami Namin Akbar , Jones Keith S. 
Published: January 2022

AbstractThe use of metaphor in cybersecurity discourse has become a topic of interest because of its ability to aid communication about abstract security concepts. In this paper, we borrow from existing metaphor identification algorithms and general theories to create a lightweight metaphor identification algorithm, which uses only one external source of knowledge. The algorithm also introduces a real time corpus builder for extracting collocates; this is, identifying words that appear together more frequently than chance. We implement several variations of the introduced algorithm and empirically evaluate the output using the TroFi dataset, a de facto evaluation dataset in metaphor research. We find first, contrary to our expectation, that adding word sense disambiguation to our metaphor identification algorithm decreases its performance. Second, we find, that our lightweight algorithms perform comparably to their existing, more complex, counterparts. Finally, we present the results of several case studies to observe the utility of the algorithm for future research in linguistic metaphor identification in text related to cybersecurity texts and threats.
Excited state dynamics of Zn–salophen complexes
Authors: O’Keeffe Patrick , Catone Daniele , Turchini Stefano , Paladini Alessandra , Dalla Cort Antonella , Bodo Enrico , Piccirillo Susanna 
Published: January 2022

AbstractZn–salophen complexes are a promising class of fluorescent chemosensors for nucleotides and nucleic acids. We have investigated, by means of steady state UV–Vis, ultrafast transient absorption, fluorescence emission and time dependent density functional theory (TD-DFT) the behavior of the excited states of a salicylidene tetradentate Schiff base (Sal), its Zn(II) coordination compound (Zn–Sal) and the effect of the interaction between Zn–Sal and adenosine diphosphate (ADP). TD-DFT shows that the deactivation of the excited state of Sal occurs through torsional motion, due to its rotatable bonds and twistable angles. Complexation with Zn(II) causes rigidity so that the geometry changes in the excited states with respect to the ground state structure are minimal. By addition of ADP to a freshly prepared Zn–Sal ethanol solution, a longer relaxation constant, in comparison to Zn–Sal, was measured, indicative of the interaction between Zn–Sal and ADP. After a few days, the Zn–Sal–ADP solution displayed the same static and dynamic behavior of a solution containing only the Sal ligand, demonstrating that the coordination of the ADP anion to Zn(II)leads to the demetallation of the Sal ligand. Fluorescence measurements also revealed an enhanced fluorescence at 375 nm following the addition of ADP to the solution, caused by the presence of 2,3-diamino naphthalene that is formed by demetallation and partial decomposition of the Sal ligand. The efficient fluorescence of this species at 375 nm could be selectively detected and used as a probe for the detection of ADP in solution.
Graphical abstract
Traffic conflict reduction based on distributed stochastic task allocation
Authors: Öreg Zs. , Shin H.-S. , Tsourdos A. 
Published: January 2022

AbstractThe aim of this paper is to provide preliminary results on a traffic coordination framework based on stochastic task allocation. General trends and the predicted advent of personal aerial vehicles increase traffic rapidly, but current air traffic management methods admittedly cannot scale appropriately. A hierarchical system is proposed to overcome the problem, the middle layer of which is elaborated in this paper. This layer aims to enable stochastic control of traffic behaviour using a single parameter, which is achieved by applying distributed stochastic task allocation. The task allocation algorithm is used to allocate speeds to vehicles in a scalable way. By regulating the speed distribution of vehicles the conflict rates remain manageable. Multi-agent simulation results show that it is possible to control ensemble dynamics and together with that traffic safety and throughput via a single parameter. Using transient simulations the dynamic performance of the system is analysed. It is shown that the traffic conflict reduction problem can be transformed into a control design problem. The performance of a simple controller is also evaluated. It was shown that by applying the controller, quicker transients can be achieved for the mean speed of the system.
Single-cell sequencing and its applications in bladder cancer
Authors: Wei Wang , Rong Yuan , Sanhe Liu , Chunxiu Yang , Thokerunga Erick , Cui Diansheng , Wang Fubing 
Published: January 2022

Abstract
Bladder cancer is the most common malignant tumour of the urinary system that is characterised by significant intra-tumoural heterogeneity. While large-scale sequencing projects have provided a preliminary understanding of tumour heterogeneity, these findings are based on the average signals obtained from the pooled populations of diverse cells. Recent advances in single-cell sequencing (SCS) technologies have been critical in this regard, opening up new ways of understanding the nuanced tumour biology by identifying distinct cellular subpopulations, dissecting the tumour microenvironment, and characterizing cellular genomic mutations. By integrating these novel insights, SCS technologies are expected to make powerful and meaningful changes to the current diagnosis and treatment of bladder cancer through the identification and usage of novel biomarkers as well as targeted therapeutics. SCS can discriminate complex heterogeneity in a large population of tumour cells and determine the key molecular properties that influence clinical outcomes. Here, we review the advances in single-cell technologies and discuss their applications in cancer research and clinical practice, with a specific focus on bladder cancer.
Directional Kronecker algebra for -actions
Authors: LIU CHUNLIN , XU LEIYE 
Published: January 2022

AbstractIn this paper, directional sequence entropy and directional Kronecker algebra for
$\mathbb {Z}^q$
-systems are introduced. The relation between sequence entropy and directional sequence entropy are established. Meanwhile, directional discrete spectrum systems and directional null systems are defined. It is shown that a
$\mathbb {Z}^q$
-system has directional discrete spectrum if and only if it is directional null. Moreover, it turns out that a
$\mathbb {Z}^q$
-system has directional discrete spectrum along q linearly independent directions if and only if it has discrete spectrum.
New approach to weighted topological entropy and pressure
Authors: TSUKAMOTO MASAKI 
Published: January 2022

AbstractMotivated by fractal geometry of self-affine carpets and sponges, Feng and Huang [J. Math. Pures Appl.106(9) (2016), 411–452] introduced weighted topological entropy and pressure for factor maps between dynamical systems, and proved variational principles for them. We introduce a new approach to this theory. Our new definitions of weighted topological entropy and pressure are very different from the original definitions of Feng and Huang. The equivalence of the two definitions seems highly non-trivial. Their equivalence can be seen as a generalization of the dimension formula for the Bedford–McMullen carpet in purely topological terms.
The effects of citrus flavonoids and their metabolites on immune-mediated intestinal barrier disruption using an in vitro co-culture model
Authors: Stevens Yala , de Bie Tessa , Pinheiro Iris , Elizalde Montserrat , Masclee Ad , Jonkers Daisy 
Published: January 2022

AbstractHesperidin and naringin are citrus flavonoids with known anti-oxidative and anti-inflammatory properties. Evidence from previous studies indicates that both these compounds and the metabolites that are formed during intestinal metabolism are able to exert beneficial effects on intestinal barrier function and inflammation. However, so far, studies investigating the relative contributions of the various compounds are lacking. Therefore, we assessed the effect of citrus flavonoids and their intestinal metabolites on immune-mediated barrier disruption in an in vitro co-culture model. Caco-2 cell monolayers were placed in co-culture with phorbol 12-myristate 13-acetate-stimulated THP-1-Blue™ NF-κB cells for 30 h. At baseline, the citrus flavonoids and their metabolites were added to the apical compartment (50 or 100 µM per compound). After 24 h, THP-1 cells were incubated with lipopolysaccharide (LPS) in the basolateral compartment for 6 h. Incubation with citrus flavonoids and their metabolites did not induce changes in transepithelial electrical resistance, fluorescein isothiocyanate–dextran 4 kDa permeation or gene expression of barrier-related genes for any of the compounds tested. After LPS stimulation, NF-κB activity was significantly inhibited by all compounds (100 µM) except for one metabolite (all P ≤ 0·03). LPS-induced production of the cytokines IL-8, TNF-α and IL-6 was inhibited by most compounds (all P < 0·05). However, levels of IL-1β were increased, which may contribute to the lack of an improved barrier effect. Overall, these results suggest that citrus flavonoids may decrease intestinal inflammation via reduction of NF-κB activity and that the parent compounds and their metabolites formed during intestinal metabolism are able to exert comparable effects.
Can individual fatty acids be used as functional biomarkers of dairy fat consumption in relation to cardiometabolic health? A narrative review
Authors: Sellem Laury , Jackson Kim G. , Paper Laura , Givens Ian D. , Lovegrove Julie A. 
Published: January 2022

AbstractIn epidemiological studies, dairy food consumption has been associated with minimal effect or decreased risk of some cardiometabolic diseases (CMD). However, current methods of dietary assessment do not provide objective and accurate measures of food intakes. Thus, the identification of valid and reliable biomarkers of dairy product intake is an important challenge to best determine the relationship between dairy consumption and health status. This review investigated potential biomarkers of dairy fat consumption, such as odd-chain, trans- and branched-chain fatty acids (FA), which may improve the assessment of full-fat dairy product consumption. Overall, the current use of serum/plasma FA as biomarkers of dairy fat consumption is mostly based on observational evidence, with a lack of well-controlled, dose–response intervention studies to accurately assess the strength of the relationship. Circulating odd-chain SFA and trans-palmitoleic acid are increasingly studied in relation to CMD risk and seem to be consistently associated with a reduced risk of type 2 diabetes in prospective cohort studies. However, associations with CVD are less clear. Overall, adding less studied FA such as vaccenic and phytanic acids to the current available evidence may provide a more complete assessment of dairy fat intake and minimise potential confounding from endogenous synthesis. Finally, the current evidence base on the direct effect of dairy fatty acids on established biomarkers of CMD risk (e.g. fasting lipid profiles and markers of glycaemic control) mostly derives from cross-sectional, animal andin vitrostudies and should be strengthened by well-controlled human intervention studies.
The effects of sex, nation, ethnicity, age and self-reported pubertal development on participant-measured right-left 2D:4D (Dr-l) in the BBC internet study
Authors: Manning J.T. , Fink B. , Mason L. , Kasielska-Trojan A. , Trivers R. 
Published: January 2022

AbstractDigit ratio (2D:4D) – a proxy for prenatal sex steroids – shows sex, nationality and ethnic differences and is linked to pubertal onset. It is unclear whether right-left 2D:4D (Dr-l) also correlates with prenatal sex steroids, as evidence of these differences has been less conclusive. The present study examined the effects of sex, nation, ethnicity, age and self-reported pubertal development (i.e. the rate of physical development and age at menarche [females] or first shave [males]) on Dr-l in a large online study (the BBC internet study). Digit lengths were self-measured in 201,865 adults (110,955 males) and the sample of nations included 41 countries. Participants reported the self-perceived rate of physical pubertal development on a five-point scale (from very slow to very fast) and provided information on the age at menarche or first shave. Adult (>17 years) males had lower Dr-l than females with weak effect size across 41 nations (males-females; d = −.065, p < .0001). There were sex and ethnicity effects on Dr-l across seven ethnic groups with males < females and lower Dr-l in Whites and Middle/Near Eastern participants compared to Asian, Black and Chinese respondents. Considering age effects, the authors focused on participants >12 years; there were stable sex differences and a weak positive effect of age on Dr-l. Dr-l showed a positive relationship with the rate of physical development and a negative relationship with age at menarche or first shave. Relationships were present in males and females with stronger effects in the latter. It is concluded that Dr-l shows a weak sex difference (males < females) independent of nation, ethnicity and age, and suggest that Dr-l is a proxy for prenatal sex steroids.
How many growing vestibular schwannomas tend to stop growing without any treatment?
Authors: Donghun K , Crowther J A , Taylor W A S , Locke R , Kontorinis G 
Published: January 2022

AbstractObjectiveTo determine the long-term, spontaneous growth arrest rates in a large cohort of vestibular schwannoma patients.MethodsThis paper describes a retrospective case series of 735 vestibular schwannoma patients organised into four groups: group A patients showed tumour growth which then stopped without any treatment; group B patients showed tumour growth which continued, but were managed conservatively; group C patients had a growing vestibular schwannoma and received active treatment; and group D patients had a stable, non-growing vestibular schwannoma. Demographics, tumour size and vestibular schwannoma growth rate (mm/month) were recorded.ResultsA total of 288 patients (39.2 per cent) had growing vestibular schwannomas. Of the patients, 103 (35.8 per cent) were managed conservatively, with 52 patients (50.5 per cent of the conservative management group, 18 per cent of the total growing vestibular schwannoma group) showing growth arrest, which occurred on average at four years following the diagnosis. Eighty-two per cent of vestibular schwannomas stopped growing within five years. Only differences between age (p = 0.016) and vestibular schwannoma size (p = 0.0008) were significant.ConclusionApproximately 20 per cent of growing vestibular schwannomas spontaneously stop growing, predominantly within the first five years; this is important for long-term management.
Systematic review and meta-analysis of the diagnostic effectiveness of positron emission tomography-computed tomography versus magnetic resonance imaging in the post-treatment surveillance of head and neck squamous cell carcinoma
Authors: Zhu Y , McLaren O , Hardman J , Evans J , Williams R 
Published: January 2022

AbstractObjectiveThere is currently no consensus on the ideal protocol of imaging for post-treatment surveillance of head and neck squamous cell carcinoma. This study aimed to consolidate existing evidence on the diagnostic effectiveness of positron emission tomography-computed tomography versus magnetic resonance imaging.MethodSystematic electronic searches were conducted using Medline, Embase and Cochrane Library (updated February 2021) to identify studies directly comparing positron emission tomography-computed tomography and magnetic resonance imaging scans for detecting locoregional recurrence or residual disease for post-treatment surveillance.ResultsSearches identified 3164 unique records, with three studies included for meta-analysis, comprising 176 patients. The weighted pooled estimates of sensitivity and specificity for scans performed three to six months post-curative treatment were: positron emission tomography-computed tomography, 0.68 (95 per cent confidence interval, 0.49–0.84) and 0.89 (95 per cent confidence interval, 0.84–0.93); magnetic resonance imaging, 0.72 (95 per cent confidence interval, 0.54–0.88) and 0.85 (95 per cent confidence interval, 0.79–0.89), respectively.ConclusionExisting studies do not provide evidence for superiority of either positron emission tomography-computed tomography or magnetic resonance imaging in detecting locoregional recurrence or residual disease following curative treatment of head and neck squamous cell carcinoma.
Acquiring the language of instruction: Effect of home language experience
Authors: Shorbagi Sadek Hefni , Dias Martins Claudia , Bialystok Ellen 
Published: January 2022

AbstractThe study followed 6-year-old children in Canadian French Immersion for three years to investigate the effect of home language background on acquisition of French, the language of schooling. None of the children knew French before beginning the program. French proficiency was indicated by French vocabulary and verbal fluency tasks. A language background questionnaire was used to (a) assign children to monolingual or bilingual groups and (b) provide a continuous score for degree of bilingual experience. Categorical analyses showed bilingual children had smaller English vocabulary than monolingual children when they entered the program. For French vocabulary, categorical comparisons revealed no language group differences in the first two years but higher French scores for bilingual children in the third year. In contrast, analyses of the continuous scores revealed a relation between more bilingual experience and higher French vocabulary throughout. Similarly, categorical analyses of verbal fluency results indicated no significant language group differences for either semantic or phonological fluency, but continuous analyses of semantic fluency showed an association between more bilingual experience and better outcomes in each year. These results suggest that language experience impacts progress in learning the language of schooling and that different analytic approaches reveal different aspects of the pattern.
Fifty shades of deservingness: an analysis of state-level variation and effect of social constructions on policy outcomes
Authors: Kreitzer Rebecca J. , Maltby Elizabeth A. , Smith Candis Watts 
Published: January 2022

AbstractA patchwork of policies exists across the United States. While citizens’ policy preferences in domains such as the criminal legal system, gun regulations/rights, immigration, and welfare are informed by their political predispositions, they are also shaped by the extent to which policy targets are viewed as deserving. This article centres the idea that collective evaluations matter in policymaking, and it ascertains whether subnational levels of deservingness evaluations of several target groups differ across space to illuminate the link between these judgements and state policy design. We leverage original survey data and multilevel regression and poststratification to create state-level estimates of deservingness evaluations. The analyses elucidate the heterogeneity in state-level deservingness evaluations of several politically relevant groups, and they pinpoint a link between these social reputations and policy design. The article also delivers a useful methodological tool and measures for scholars of state policy design to employ in future research.
THE BRAZILIAN ECONOMY DURING THE OLD REGIME CRISIS (1750-1807)
Authors: Carrara Angelo Alves , Menz Maximiliano Mac , Melo Felipe Souza , Dominguez Rodrigo da Costa 
Published: January 2022

ABSTRACTWhile some authors defend the existence of a widespread economic crisis in Brazil during the 18th century, motivated by the fall in the extraction of precious metals, others suggest that the colonial economy maintained a positive performance thanks to the growth of its domestic market. The main goal of this article is to challenge these two explanations, showing that different rhythms of development characterised Brazil's economy in each of its regions. We show that between the 1750s and 1790s, the Amazon region (Maranhão and Pará) experienced uninterrupted growth. Despite some fluctuations, Bahia and Pernambuco showed a tendency towards growth while the centre-south (Rio de Janeiro and Minas Gerais) suffered an economic contraction. We conclude that there was a stagnation in the added value of exports from all regions, whilst simultaneous growth for all territories occurred only after 1790.
Useful charlatans: Giovanni Succi and Stefano Merlatti’s fasting contest in Paris, 1886
Authors: Nieto-Galan Agustí 
Published: January 2022

ArgumentThis paper analyzes the public fasts of two Italian “hunger artists,” Giovanni Succi and Stefano Merlatti, in Paris in 1886, and their ability to forego eating for a long period (thirty and fifty days respectively). Some contemporary witnesses described them as clever frauds, but others considered them to be interesting physiological anomalies. Controversies about their fasts entered academic circles, but they also spread throughout the urban public at different levels. First, Succi and Merlatti steered medical debates among physicians on the “scientific” explanations of the limits of human resistance to inanition, and acted as ideal mediators for doctors’ professional interests. Second, they became useful tools for science popularizers in their attempt to gain authority in drawing the boundaries between “orthodox” and “heterodox” knowledge. Finally, in the 1880s, Succi and Merlatti’s contest, the controversy around the liquids they ingested, and their scientific supervision by medical doctors, all reinforced their own professional status as itinerant fasters in a golden decade for that kind of endeavor. For all those reasons, Succi and Merlatti can be viewed as useful, epistemologically-active charlatans.