bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disentangling entangled mobilities: reflections on forms of knowledge production within migration studies
Authors: Wyss Anna , Dahinden Janine 
Published: August 2022

AbstractEuropean migration studies have been criticised for having certain epistemological and theoretical underpinnings that reproduce hegemonic structures, especially the ‘national order of things’ and colonial legacies. In this article, we propose the concept of ‘entangled mobilities’ to address some of these challenges. Entangled mobilities as a theoretical lens enables us to study specific global and transnational processes, the ways in which they are historically and locally situated, and how they materialise in individual mobilities of differently positioned actors within an unequal political global economy. This lens helps us simultaneously overcome nationality- and ethnicity-centred epistemologies, confront colonial aphasia, and be sensitive to the multiple inequalities and mobility regimes within which human mobilities evolve. Furthermore, the prism of entangled mobilities provides an ideal methodological departure point from which to systematically examine how human mobilities are intertwined and interdependent and to reveal how they are embedded in and shaped by asymmetric, historically evolved power structures. We propose three pragmatic entry points for mobilising the concept: in specific places, in terms of the intersections and interdependencies of different mobile people, and in the context of the biographical trajectories of individuals. Finally, we invite scholars from other fields, such as policy research, to innovatively adapt this approach to gain alternative knowledge and address inequalities.
Use of remimazolam in living donor liver transplantation: a case report
Authors: Matsumoto Tsuguhiro , Sakurai Kotaro , Takahashi Kazuyo , Kawamoto Shuji 
Published: August 2022

Abstract
Background
Remimazolam is an intravenous ultra-short-acting benzodiazepine with the benefit of hemodynamic stability, including blood pressure and pulse rate. We report a case in which remimazolam was used in living donor liver transplantation with stable hemodynamics.

Case presentation
A 19-year-old woman underwent living donor liver transplantation due to end-stage liver disease, which is associated with a hyperdynamic state and hemodynamic instability. The patient’s sister had a history of malignant hyperthermia, so we chose total intravenous anesthesia with remimazolam. Intraoperative bleeding of seven liters occurred, but she had mild intraoperative blood pressure changes, and continuous catecholamine administration was not necessary. The patient had no memories or discomfort during the surgery.

Conclusions
We maintained stable hemodynamics using remimazolam for anesthetic management of a patient undergoing a liver transplantation, which is characterized by a hyperdynamic state and circulatory instability.
Occurrence and anti-microbial susceptibility pattern of extended spectrum beta-lactamase producing Enterobacteriaceae in governmental hospitals wastewater in Addis Ababa, Ethiopia
Authors: Kebede Alehegn Amare , Bedada Tesfaye Legesse , Teklu Dejenie Shiferaw , Beyene Degefu , Tullu Kassu Desta 
Published: August 2022

Abstract
Background
Worldwide, come out and dissemination of extended-spectrum beta-lactamases (ESBLs) producing Enterobacteriaceae has been warning the efficacy of antibiotics to treat an infection. Hospital wastewaters were a reservoir of such kind of resistant bacteria. Currently, the predominant antibiotics used for the treatment of hospitalized patients infected by Gram-negative bacteria are the β-lactam antibiotics. Therefore, it is an important source to investigate the magnitude of ESBLs producing bacteria and their antimicrobial susceptibility pattern. This study aimed to determine the occurrence of ESBLs producing Enterobacteriaceae (ESBLs-pE) and their antibiotic susceptibility pattern in wastewater released from five governmental hospitals in Addis Ababa, Ethiopia.

Methods
A cross-sectional study was conducted from April 1 to May 31, 2020. A total of 100 wastewaters were collected from five governmental hospitals in Addis Ababa using a grap-sampling technique. All Enterobacteriaceae were screened for ESBLs production using cefotaxime and ceftazidime as per 29th CLSI guideline. Each screen positive for ESBLs production was confirmed by the combination disk method (CDT) and their antibiotic susceptibility pattern was done using the Kirby–Bauer disk diffusion method on Muller Hinton agar (MHA). Data were entered and summarized using SPSS version 20 software.

Results
Of all Enterobacteriaceae, 48.3% were confirmed ESBLs-pE. The highest ratio of ESBLs-PE was observed in the adult ward (66.7%) and laundry unit effluent (58.8%). The highest ESBL producers were E. coli (21.8%) and K. pneumoniae (4.8%). The most elevated resistance level of ESBL producers were observed to cefotaxime (95.8%) and amoxicillin/clavunalate (93%). 64% of tested Enterobacteriaceae isolates were multi drug resistant (MDR).

Conclusions
Higher magnitude of MDR and ESBLs-pE were present in the hospital wastewater. The majority of them were in the adult ward and laundry unit effluents. The most frequent ESBLs-pE was among E.coli and K. pneumoniae. Hence, Consistent infection prevention and control procedures should be in practice at each ward/unit.
Importance of appropriate genome information for the design of mating type primers in black and yellow morel populations
Authors: Cravero Melissa , Robinson Aaron J. , Hilpisch Patrick , Chain Patrick S. , Bindschedler Saskia , Junier Pilar 
Published: August 2022

AbstractMorels are highly prized edible fungi where sexual reproduction is essential for fruiting-body production. As a result, a comprehensive understanding of their sexual reproduction is of great interest. Central to this is the identification of the reproductive strategies used by morels. Sexual reproduction in fungi is controlled by mating-type (MAT) genes and morels are thought to be mainly heterothallic with two idiomorphs, MAT1-1 and MAT1-2. Genomic sequencing of black (Elata clade) and yellow (Esculenta clade) morel species has led to the development of PCR primers designed to amplify genes from the two idiomorphs for rapid genotyping of isolates from these two clades. To evaluate the design and theoretical performance of these primers we performed a thorough bioinformatic investigation, including the detection of the MAT region in publicly available Morchella genomes and in-silico PCR analyses. All examined genomes, including those used for primer design, appeared to be heterothallic. This indicates an inherent fault in the original primer design which utilized a single Morchella genome, as the use of two genomes with complementary mating types would be required to design accurate primers for both idiomorphs. Furthermore, potential off-targets were identified for some of the previously published primer sets, but verification was challenging due to lack of adequate genomic information and detailed methodologies for primer design. Examinations of the black morel specific primer pairs (MAT11L/R and MAT22L/R) indicated the MAT22 primers would correctly target and amplify the MAT1-2 idiomorph, but the MAT11 primers appear to be capable of amplifying incorrect off-targets within the genome. The yellow morel primer pairs (EMAT1-1 L/R and EMAT1-2 L/R) appear to have reporting errors, as the published primer sequences are dissimilar with reported amplicon sequences and the EMAT1-2 primers appear to amplify the RNA polymerase II subunit (RPB2) gene. The lack of the reference genome used in primer design and descriptive methodology made it challenging to fully assess the apparent issues with the primers for this clade. In conclusion, additional work is still required for the generation of reliable primers to investigate mating types in morels and to assess their performance on different clades and across multiple geographical regions.
Early versus late onset depression: sociodemographic and clinical characteristics
Authors: Sayed Taher Abdelraheem , Mahmoud Osama Abd Alreheem , Hadad Saber 
Published: August 2022

Abstract
Background
Late-onset depression is different from early-onset depression in its sociodemographic and clinical characteristics and risk factors. This study aimed to demonstrate the differences in sociodemographic characteristics as well as clinical presentation between late-onset depression (after the age of 60 years) and early-onset depression (before the age of 45 years) and to determine the sociodemographic risk factors for late onset depression. Fifty-five patients between 18 and 45 years of age (group 1) and 55 patients aged 60 years and above (group 2) diagnosed for the first time with major depressive disorder were compared regarding sociodemographic and clinical characteristics. They were recruited from the psychiatric clinic at Sohag University Hospital. All participants were subjected to a Structured Clinical Interview for DSM-IV (SCID-IV), sociodemographic data form, Beck Depression Inventory-Second Edition (BDI-II), and Apathy Evaluation Scale (AES).

Results
The patients in group 2 were more commonly single (29%), employed (74.54%), living in rural areas (56.36%), and had high school education (41.81%). While the patients in group 2 were more commonly widows (18.18%), unemployed (61.81%), had less than high school education (47.27%), and had chronic diseases (78.81%). Significant risk factors for late onset depression are being widow, unemployed, having low socioeconomic status, and having a chronic medical disease. Patients with late-onset depression were more commonly presented with apathy, cognitive impairment, and somatic symptoms, as well as sleep disturbance (mean±SD 57±6, 70.9%, 61.81%, and 81.81%, respectively) than early-onset depression (mean±SD 49± 4, 47.27%, 36.36%, and 70.9%, respectively).

Conclusions
Cases with late onset depression are featured by being unemployed, widow, having low socioeconomic status and low educational level, suffering from a chronic medical condition and living in an urban area. In late onset depression, somatic symptoms, apathy, sleep disturbances, as well as cognitive impairment are prevalent presenting symptoms.
Correlation of miR-31 and miR-373 expression with KRAS mutations and its impact on prognosis in colorectal cancer
Authors: Ashoori Hasan , Kamian Shaghayegh , Vahidian Farnaz , Ghamarchehreh Mohammad Ebrahim 
Published: August 2022

Abstract
Introduction
Colorectal cancers (CRC) are among the most common cancers. There are different modalities for treatment including chemotherapy, surgery, and radiotherapy. There are some mutations in cancers which can assist in the treatment and better prognosis of patients. In this study, two molecular markers (miR-31 and miR-373) were involved in the pathogenesis of CRC and their association with histopathological features was investigated. As well, the prognostic value of these molecular markers was investigated in CRC patients with or without common KRAS mutations.

Methods
Paraffin blocks of tissue samples from 150 patients who underwent colon surgery between 2018 and 2020 were prepared by the Pathology Department of Imam Hossein Hospital (Tehran, Iran). After DNA and RNA isolation, gene expression of miR-31 and miR-373 was determined using probe-based quantitative real-time polymerase chain reaction (qRT-PCR). Mutations of KRAS were surveyed using conventional PCR and agarose gel electrophoresis.

Results
The mean age of the patients was 57.2 ± 13.4 years. KRAS codon 12 and 13 mutations were positive in 31 (20.6%) and 22 (14.6%) cases, respectively. The results showed that KRAS common mutations occurred in 32.6% of Iranian CRC patients. The expression levels of miR-31 and miR-373 increased in CRC patients with KRAS mutations in comparison with patients without these mutations.

Conclusion
Considering the role of miR-31 and miR-373 in CRC tumor progression, it seems that the CRC patients bearing KRAS mutations have a poorer prognosis respective to patients without KRAS mutations.
Quality and Safety With Technological Advancements in Radiotherapy: An Overview and Journey Narrative From a Low- and Middle-Income Country Institution
Authors: Manjali Jifmi Jose , Krishnatry Rahul , Palta Jatinder R. , Agarwal J.P. 
Published: August 2022

PURPOSE To present an overview of quality and safety in radiotherapy from the context of low- and middle-income countries on the basis of a recently conducted annual meeting of our institution and our experience of implementing an error management system at our center. METHODS The minutes of recently concluded annual Evidence-Based Medicine (EBM-2021) meeting on the basis of technology in radiation oncology were reviewed. The session on quality and safety, which had international experts as speakers, was reviewed. Along with this, we reviewed the literature for preventive and reactive measures proposed to manage errors including error reporting and learning systems (ILSs). Concise summary for the same was prepared for this article. RESULTS We also reviewed the journey of development of our institutional ILS and present here a summary of achievements, challenges, and future vision. CONCLUSION Preventive and reactive measures must be followed to achieve high-quality and safe radiotherapy. Despite resource constraints, a successful ILS program can be developed in a low- and middle-income country center by first understanding the patterns of error and developing one that suits the working ecosystem.
Paternally inherited H3K27me3 affects chromatin accessibility in mouse embryos produced by round spermatid injection
Authors: Sakamoto Mizuki , Ito Daiyu , Inoue Rei , Wakayama Sayaka , Kikuchi Yasuyuki , Yang Li , Hayashi Erika , Emura Rina , Shiura Hirosuke , Kohda Takashi , Namekawa Satoshi H. , Ishiuchi Takashi , Wakayama Teruhiko , Ooga Masatoshi 
Published: August 2022

ABSTRACT
Round spermatid injection (ROSI) results in a lower birth rate than intracytoplasmic sperm injection, which has hampered its clinical application. Inefficient development of ROSI embryos has been attributed to epigenetic abnormalities. However, the chromatin-based mechanism that underpins the low birth rate in ROSI remains to be determined. Here, we show that a repressive histone mark, H3K27me3, persists from mouse round spermatids into zygotes in ROSI and that round spermatid-derived H3K27me3 is associated with less accessible chromatin and impaired gene expression in ROSI embryos. These loci are initially marked by H3K27me3 but undergo histone modification remodelling in spermiogenesis, resulting in reduced H3K27me3 in normal spermatozoa. Therefore, the absence of epigenetic remodelling, presumably mediated by histone turnover during spermiogenesis, leads to dysregulation of chromatin accessibility and transcription in ROSI embryos. Thus, our results unveil a molecular logic, in which chromatin states in round spermatids impinge on chromatin accessibility and transcription in ROSI embryos, highlighting the importance of epigenetic remodelling during spermiogenesis in successful reproduction.
Case studies 1–3: leg ulcers
Authors: Tickle Joy 
Published: August 2022

Case studies are presented here by a tissue viability nurse consultant and an advanced podiatrist demonstrating the use of ChloraSolv in clinical practice. The first set of cases is from a community setting, where the tissue viability nurse and district nurse successfully used the product to fully debride hard-to-heal leg ulcers in patients who mostly had been unable to tolerate other forms of debridement. The second set illustrates its use in a podiatry clinic, where the gel removed dry, adherent slough. ‘These case studies show that ChloraSolv can be used by any health professional to achieve a clean wound bed’
Pharmacotherapeutics of aprepitant and pregabalin in neuropathic pain and refractory pruritus in a patient diagnosed with a cutaneous T-cell lymphoma
Authors: Keenan Michelle 
Published: August 2022

Background/AimsPalliative care nurse specialists are required to have a high level of knowledge and expertise in the management of complex symptoms. As a result of patient complexity, clinicians are often faced with advising on multiple drug regimes. This often requires clinical nurse specialists to have knowledge of pharmacotherapeutics to ensure safe and rational prescribing. In the form of a case study, the author has critically discussed the use of aprepitant and pregabalin in the management of neuropathic pain and refractory pruritus in a patient diagnosed with a cutaneous T cell lymphoma. These drugs are not routinely prescribed together and therefore the author has explored potential pharmacokinetic interactions.Case presentationThe case presented a 49-year-old lady with an advanced metastatic cutaneous T-cell lymphoma with failed remission despite extensive oncological treatment. She was referrd to the to hospital specialist palliative care team for treatment of refractory pruritus and neuropathic pain.ConclusionAprepitant is considered an effective anti-pruritic agent that is normally well tolerated; however, careful consideration must be taken because of extensive drug interactions. Caution is also required in patients with hepatic impairment. Pregabalin is often used in specialist palliative care for the management of neuropathic pain because of its efficacy and ease of titration. Caution must be taken in prescribing in patients with renal impairment. As pregabalin is not bound to plasma proteins nor metabolised by the liver, the risk of pharmacokinetic interaction with aprepitant is minimal. As both drugs cross the blood brain-barrier, clinicians must monitor for adverse central nervous system activity. This case study highlights the importance of pharmacotherapeutics in ensuring safe and rational prescribing, with the need to continue to integrate this knowledge into future practice as nurse prescribers.
Design, fabrication, and testing of an all-metal ultra-compact telescope
Authors: Zhao Zhi-Cheng , Chen Xin-Hua , Shen Wei-Min 
Published: August 2022

The design, fabrication, and testing of an all-metal four-mirror telescope for high-resolution remote sensing is presented in this paper. The system works in the visible (VIS) band and is designed with a focal length of 1406 mm, an aperture of 200 mm, and a full field of view (FOV) of 1.32°. The mechanical structure is designed to realize the snap-together alignment. The primary mirror (M1) and tertiary mirror (M3) are designed as a co-substrate element to simplify the fabrication and alignment. The telescope’s weight is 3.5 kg, and the volume is just

φ

230

×

220

m
m

3

. Metallic mirrors are fabricated with single-point diamond turning, and post-polishing is used to correct the mirror’s surface form deviation and remove turning tool marks effectively. After polishing, the RMS value of the mirror surface form deviation of the final mirror can reach

0.02

λ

at

λ
=

632.8

n
m

, and the surface roughness Ra value is about 1.83 nm. Benefiting from the all-metal mechanical design, the alignment process of the telescope is fast and accurate. The interferometric wavefront, modulation transfer function, and focal length of the telescope are measured, and the results demonstrated that it achieves the near-diffraction-limited imaging performance.
Delay-aware and resource-efficient service function chain mapping in inter-datacenter elastic optical networks
Authors: Zhu Min , Gu Jiahua , Shen Tianyu , Zhang Jiao , Gu Pingping 
Published: August 2022

Network function virtualization (NFV) is emerging as a promising paradigm for network architectures. By migrating network functions from dedicated hardware appliances to software instances running in a virtualized environment, NFV promises to offer a more flexible way to deploy and manage service function chains (SFCs). When deploying these SFCs to users, the network operators require not only the user’s demands (e.g., end-to-end delay) to be satisfied, but require the cost of SFC mapping to be minimized (e.g., resource consumption). To fulfill these two goals, in this paper, we have investigated how to realize the delay-aware and resource-efficient SFC mapping in inter-datacenter elastic optical networks. We first formulate an integer linear programming (ILP) model to solve the problem exactly. The main optimization goal in the ILP model is to jointly minimize resource consumption and end-to-end delay to achieve optimal virtual network function placement. Then, a delay-aware and load-balancing mapping algorithm (DALB-MA) is proposed to obtain a near-optimal solution in a reasonable amount of time. Finally, we evaluate the proposed ILP model and heuristic algorithms via extensive simulations. The results indicate that the proposed ILP model and the DALB-MA outperform the benchmarks in terms of block rate, average cost, number of CPUs used, maximum frequency slot index, and delay margin gain.
Investigation on the determinant of upconversion luminescence efficiency and temperature measurement sensitivity based on AWO4 (Ba, Sr, Ca, and Mg): Er3+/Yb3+ microcrystals
Authors: Liu Hang , Zheng Xingke , Wang Pengcheng , Wang Haiyan , Zhang Yuhong 
Published: August 2022

In this work, a comparative study of the upconversion (UC) luminescence properties of

E
r

3
+

−

Y
b

3
+

-co-doped

A
W
O

4

(

A

=

B
a

, Sr, and Ca) scheelite phosphors and

E
r

3
+

−

Y
b

3
+

-co-doped

M
g
W
O

4

wolframite phosphors is reported. Under 980 nm excitation, all the samples emit green and red emissions. The

E
r

3
+

−

Y
b

3
+

-doped

M
g
W
O

4

phosphor has a higher UC emission intensity. Furthermore, the optical temperature sensing properties in

E
r

3
+

−

Y
b

3
+

-co-doped

A
W
O

4

(

A

=

B
a

, Sr, Ca, and Mg) phosphor samples are investigated. The relative sensitivity (

S

r

) based on thermally coupled levels (TCLs) increases gradually with an increase in matrix phonon energy. The absolute sensitivity (

S

a

) values of the samples are accurately predicted by the chemical bonding parameter (

f

c

). The results of the correlation between the UC luminescence properties and the microscopic crystal structure, and the relationship of the temperature sensitivity and the host parameters, provide us with a guiding insight for the selection of a host material with ideal temperature measurement capability.