bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic Abnormalities in Association with Clinical Neonatal Seizures in an Indian Tertiary Care Centre
Authors: Y. Ramesh Bhat , PD Sandeep 
Published: October 2022

AbstractMetabolic disturbances frequently occur in neonatal seizures either as an underlying cause or as an associated abnormality. A prompt recognition of metabolic abnormalities and early therapy are necessary to avoid poor neurological outcome. Neonates with clinical seizures were enrolled in the study. Diagnostic evaluation included complete blood count, sepsis screen, and estimation of blood glucose, serum sodium, calcium and magnesium before instituting any specific treatment. Metabolic abnormalities were considered as isolated when hypoxic ischemic encephalopathy (HIE), sepsis, intracranial hemorrhage, and polycythemia were ruled out. Among 80 newborns with clinical seizures, one metabolic abnormality was detected in 46 (57.5%) newborns. The commonest metabolic abnormality observed was hypoglycemia, noted in 22/80 (27.5%) newborns. Hypocalcemia was the second common abnormality, noted in 10/80 (12.5%) newborns. Isolated metabolic abnormalities were observed in 23.8% (19/80) of newborns with seizures. Associated morbidities with seizures included HIE in 21 (26.3%) and sepsis in 28 (35%). Hypoglycemia was the commonest isolated metabolic abnormality (12.5%). Metabolic abnormalities co-existed with HIE in nine out of 21 neonates and with sepsis in eight out of 28 neonates. Hypoglycemia was the common abnormality associated with both the conditions. Inborn errors of metabolism constituted 8.8% of the cohort studied (7 of 80 patients). A metabolic abnormality was detected in more than 50% neonates with clinical seizures enrolled in our study. Metabolic abnormality also co-exists in neonates with HIE as well as sepsis-related seizures.
Temperature tunable electromagnetically induced transparency in terahertz metasurface fabricated on ferroelectric platform
Authors: Devi Koijam Monika , Jana Arun , Rane Shreeya , Roy Choudhury Palash , Roy Chowdhury Dibakar 
Published: October 2022

Abstract
The integration of active materials in terahertz (THz) metasurfaces is pivotal for the realization of functional device applications in diverse fields like sensing, imaging, communication, etc. In this context, ferroelectric materials endowed with tunable electro-optic properties have recently emerged as a novel candidate for achieving actively tuned THz metasurfaces. Here, we experimentally investigate temperature tuning of electromagnetically induced transparency (EIT) effects in a THz metasurface based on ferroelectric barium titanate (BaTiO3 (BTO)) thin film. We characterize tunable dielectric properties of the BTO thin film under variable temperatures (25 °C–100 °C) at THz frequencies by utilizing THz-time domain spectroscopy technique. Based on this aspect, we design a THz metasurface capable of displaying the EIT effect. THz transmissions through the metasurface sample are then probed for different applied temperatures. The EIT features undergo frequency shifts along with amplitude modulations owing to the temperature induced variations of the dielectric properties of the BTO thin film. A total red shift ∼27 GHz in EIT resonance dip is observed experimentally as the temperature increases from 25 °C to 100 °C. Therefore, we demonstrate utilities of ferroelectric platform toward the development of temperature tunable EIT metasurfaces.
Reversible exchange bias in epitaxial V2O3/Ni hybrid magnetic heterostructures
Authors: Ignatova K , Thorsteinsson E B , Jósteinsson B A , Strandqvist N , Vantaraki C , Kapaklis V , Devishvili A , Pálsson G K , Arnalds U B 
Published: October 2022

Abstract
In this work we present a temperature and angular dependent study of the structural and magnetic properties in highly crystalline V2O3/Ni/Zr magnetic heterostructure films. Our investigation focuses on the coupling between the ferromagnetic Ni layer and V2O3 layer which undergoes an antiferromagnetic/paramagnetic phase transition coupled to the structural phase transition of the material at around 150 K. Structural investigations using x-ray diffraction reveal highly crystalline films of a quality which has previously not been reported in the literature. The Ni layers display an absence of in-plane magnetic anisotropy owing to the highly textured (1 1 1) layering of the Ni films on the underlying V2O3(0 0 0 1) oriented layer. During the transition we observe a strain related enhancement of the coercivity and the onset of a weak exchange bias for cooling under an external magnetic field. Heating the films to above the transition temperature, the exchange bias in the Ni is removed and can be reversed upon subsequent cooling under an inverted external magnetic field. Using temperature dependent polarized neutron reflectometry we investigate the film structure at the interface, capturing the magnetic and nuclear profiles.
Tumor microenvironment and redox dual stimuli-responsive polymeric nanoparticles for the effective cisplatin-based cancer chemotherapy
Authors: Jia Yi-Yang , Huan Meng-Lei , Wang Wei , Jia Zhou-Yan , Wan Yu-Hang , Zhou Si-Yuan , Zhang Bang-Le 
Published: October 2022

Abstract
The serious side effects of cisplatin hindered its clinical application and the nanotechnology might be the potential strategy to address the limitation. However, rapid clearance in the blood circulation and ineffective controlled drug release from nanocarriers hamper the therapeutic efficacy of the nano-delivery system. We constructed a tumor microenvironment and redox dual stimuli-responsive nano-delivery system PEG-c-(BPEI-SS-Pt) by cross-linking the disulfide-containing polymeric conjugate BPEI-SS-Pt with the dialdehyde group-modified PEG2000 via Schiff base. After optimized the cross-linking time, 72 h was selected to get the nano-delivery system. 1H NMR and drug release assays showed that under the acidic tumor microenvironment (pH 6.5–6.8), the Schiff base can be broken and detached the PEG cross-linked outer shells, displaying the capability to release the drugs with a sequential pH- and redox-responsive manner. Moreover, PEG-c-(BPEI-SS-Pt) showed more effective anti-tumor therapeutic efficacy in vivo with no significant side effects when compared with the drug of cisplatin used in the clinic. This strategy highlights a promising platform with the dual stimuli-responsive profile to achieve better therapeutic efficacy and minor side effects for platinum-based chemotherapy.
3D homogenization of the T-A formulation for the analysis of coils with complex geometries
Authors: Vargas-Llanos Carlos Roberto , Huber Felix , Riva Nicolò , Zhang Min , Grilli Francesco 
Published: October 2022

Abstract
The modeling and analysis of superconducting coils is an essential task in the design stage of most devices based on high-temperature superconductors (HTS). These calculations allow verifying basic estimations and assumptions, proposing improvements, and computing quantities that are not easy to calculate with an analytical approach. For instance, the estimation of losses in HTS is fundamental during the design stage since losses can strongly influence the cooling system requirements and operating temperature. Typically, 2D finite element analysis is used to calculate AC losses in HTS, due to the lack of analytical solutions that can accurately represent complex operating conditions, such as AC transport current and AC external applied magnetic field in coils. These 2D models are usually a representation of an infinitely long arrangement. Therefore, they cannot be used to analyze end effects and complex 3D configurations. In this publication, we use the homogenization of the T-A formulation in 3D for the analysis of superconducting coils with complex geometries where a 2D approach cannot provide accurate analyses and verification of assumptions. The modeling methodology allows an easier implementation in commercial software (COMSOL Multiphysics) in comparison with the currently available 3D H homogenization, despite the complexity of the geometry. This methodology is first validated with a racetrack coil (benchmark case) by comparing the results with the well-established H formulation. Then, the electromagnetic behavior of coils with more complex geometries is analyzed.
SPECULOOS Northern Observatory: Searching for Red Worlds in the Northern Skies
Authors: Burdanov Artem Y. , Wit Julien de , Gillon Michaël , Rebolo Rafael , Sebastian Daniel , Alonso Roi , Sohy Sandrine , Niraula Prajwal , Garcia Lionel , Barkaoui Khalid , Chinchilla Patricia , Ducrot Elsa , Murray Catriona A. , Pedersen Peter P. , Jehin Emmanuël , McCormac James , Zúñiga-Fernández Sebastián 
Published: October 2022

Abstract
SPECULOOS is a ground-based transit survey consisting of six identical 1 m robotic telescopes. The immediate goal of the project is to detect temperate terrestrial planets transiting nearby ultracool dwarfs (late M-dwarf stars and brown dwarfs), which could be amenable for atmospheric research with the next generation of telescopes. Here, we report the developments of the northern counterpart of the project—SPECULOOS Northern Observatory, and present its performance during the first three years of operations from mid-2019 to mid-2022. Currently, the observatory consists of one telescope, which is named Artemis. The Artemis telescope demonstrates remarkable photometric precision, allowing it to be ready to detect new transiting terrestrial exoplanets around ultracool dwarfs. Over the period of the first three years after the installation, we observed 96 objects from the SPECULOOS target list for 6000 hr with a typical photometric precision of 0.5%, and reaching a precision of 0.2% for relatively bright non-variable targets with a typical exposure time of 25 s. Our weather downtime (clouds, high wind speed, high humidity, precipitation and/or high concentration of dust particles in the air) over the period of three years was 30% of overall night time. Our actual downtime is 40% because of additional time loss associated with technical problems.
Dependence of the tidal deformability of neutron stars on the nuclear equation of state*
Authors: Xie 谢 Wen-Jie 文杰 , Chen 陈 Jian-Ling 建玲 , Ma 马 Zi-Wei 紫微 , Guo 郭 Jun-Hua 俊华 , Zhu 祝 Long 龙 
Published: October 2022

Abstract
Within the Bayesian framework, using an explicitly isospin-dependent parametric equation of state (EOS) for the core of neutron stars (NSs), we studied how the NS EOS behaves when we confront it with the tidal deformabilities

of canonical NSs with different error and different lower boundaries, and with the tidal deformabilities of massive NSs. We found that it does not significantly improve the constraints on the NS EOS but has a weak effect on narrowing down the slope parameter of the symmetry energy by decreasing the measurement errors of

. Both the isospin-dependent and isospin-independent parts of the NS EOS were significantly constrained and raised as the tidal deformabilities of massive NSs were adopted in the calculations, especially in high-density regions. We also found that

is more competent to limit the curvature parameter than the slope parameter of the symmetry energy, whereas the opposite occurs for the radius of canonical NSs

. The tidal deformability of an NS with two times the solar mass

is more sensitive to skewness than the curvature parameter of the symmetry energy, and

and

have no correlation with the former.
Study on the effect of focal position change on the expansion velocity and propagation mechanism of plasma generated by millisecond pulsed laser-induced fused silica
Authors: WANG Lixue , CAI Jixing 
Published: October 2022

Abstract
In this work, by controlling the positional relationship between the target and the focal point, the surface damage, shock wave phenomenon and propagation mechanism involved in the plasma generation of fused silica by millisecond pulsed laser irradiation at different focal positions were studied. Laser energy is an important experimental variable. The dynamic process of plasma was detected by optical shadow method, and the influence of surface film damage on plasma propagation and the propagation mechanism at different focal positions were discussed. The study found that the plasma induced by the pulsed laser at the focus position within 0–20 μs exploded, the micro-droplets formed around 20 μs. At the same time, a shock wave is formed by the compressed air, the micro-droplets are compressed under the action of the shock wave recoil pressure, and the micro-droplets channel phenomenon is observed in the micro-droplets. The peak velocities of plasma and combustion wave appear earlier in the pre-focus position than in the post-focus position. This research provides a reference for the field of laser processing using fused silica as the substrate.
An updated overview of experimental and computational approaches to identify non-canonical DNA/RNA structures with emphasis on G-quadruplexes and R-loops
Authors: Shi Xiaohui , Teng Huajing , Sun Zhongsheng 
Published: October 2022

Abstract
Multiple types of non-canonical nucleic acid structures play essential roles in DNA recombination and replication, transcription, and genomic instability and have been associated with several human diseases. Thus, an increasing number of experimental and bioinformatics methods have been developed to identify these structures. To date, most reviews have focused on the features of non-canonical DNA/RNA structure formation, experimental approaches to mapping these structures, and the association of these structures with diseases. In addition, two reviews of computational algorithms for the prediction of non-canonical nucleic acid structures have been published. One of these reviews focused only on computational approaches for G4 detection until 2020. The other mainly summarized the computational tools for predicting cruciform, H-DNA and Z-DNA, in which the algorithms discussed were published before 2012. Since then, several experimental and computational methods have been developed. However, a systematic review including the conformation, sequencing mapping methods and computational prediction strategies for these structures has not yet been published. The purpose of this review is to provide an updated overview of conformation, current sequencing technologies and computational identification methods for non-canonical nucleic acid structures, as well as their strengths and weaknesses. We expect that this review will aid in understanding how these structures are characterised and how they contribute to related biological processes and diseases.
Evolutionary aspects of the parasitoid life strategy, with a particular emphasis on fly–spider interactions
Authors: Sýkora Jakub , Barták Miroslav , Heneberg Petr , Korenko Stanislav 
Published: October 2022

AbstractParasitoids are significant ecological elements of terrestrial food webs and have evolved within seven insect orders. Interestingly, however, associations with spiders as hosts have evolved only in two insect orders, Diptera and Hymenoptera. Here, we summarize various aspects of host utilization by dipteran flies with an emphasis on associations with spiders. Our synthesis reveals that spider flies (family Acroceridae) have evolved a unique life strategy among all the parasitoid taxa associated with spiders, in which koinobiont small-headed flies utilize an indirect oviposition strategy. This indirect oviposition in spider flies is inherited from Nemestrinimorpha ancestors which appeared in the Late Triassic and is characterized by the evolution of planidial larvae. Further, we discuss the advantages and disadvantages of indirect oviposition in spider flies. On the one hand, indirect oviposition allows the fly to avoid contact/wrestling with spider hosts. On the other hand, larval survival is low because the planidium must actively seek out and infect a suitable host individually. The risk of failure to find a suitable spider host is offset by the fly’s extremely high fecundity.
Impact of cumulative complications on 1-year treatment-related healthcare costs in patients with colorectal peritoneal metastases undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
Authors: van der Zant Femke A , Kooijman Bob J L , Hentzen Judith E K R , Helfrich Wijnand , Ploeg Emily M , van Ginkel Robert J , van Leeuwen Barbara L , Been Lukas B , Klaase Joost M , Hemmer Patrick H J , van der Hilst Christian S , Kruijff Schelto 
Published: October 2022

Abstract

Background
The aim of this study was to evaluate the impact of all minor and major complications on treatment-related healthcare costs in patients who undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of colorectal peritoneal metastases (PMs).

Method
Patients with histologically proven colorectal PMs who underwent CRS + HIPEC from March 2006 to October 2019 in a tertiary referral centre were retrospectively identified from a prospectively maintained database. Patients were divided into six subgroups according to the severity of the complications, which were scored using the comprehensive complication index (CCI) (CCI 0–9.9, CCI 10–19.9, CCI 20–29.9, CCI 30–39.9, CCI 40–49.9, and CCI 50 or higher). Treatment-related healthcare costs up to 1 year after CRS + HIPEC were obtained from the financial department. Differences in costs and survival outcomes were compared using the chi-squared test and Kruskal–Wallis H test.

Results
A total of 142 patients were included (CCI 0–9.9, 53 patients; CCI 10–19.9, 0 patients; CCI 20–29.9, 45 patients; CCI 30–39.9, 14 patients; CCI 40–49, 9 patients; and CCI 50 or higher, 21 patients). Median (interquartile range) treatment-related healthcare costs increased significantly and exponentially for the CCI 30–39, CCI 40–49, and CCI 50 or higher groups (€48 993 (€44 262–€84 805); €57 167 (€43 047–€67 591); and €82 219 (€55 487–€145 314) respectively) compared with those for the CCI 0–9.9 and CCI 20–29.9 groups (€33 856 (€24 433–€40 779) and €40 621 (€31 501–€58 761) respectively, P &lt; 0.010).

Conclusion
Treatment-related healthcare costs increase exponentially as more complications develop among patients who undergo CRS + HIPEC for the treatment of colorectal PMs. Anastomotic leakages after CRS + HIPEC lead to an increase of 295 per cent of treatment-related healthcare costs.
Precise motor rhythmicity relies on motor network responsivity
Authors: Uehara Kazumasa , Togo Hiroki , Hanakawa Takashi 
Published: October 2022

AbstractRhythmic movements are the building blocks of human behavior. However, given that rhythmic movements are achieved through complex interactions between neural modules, it remains difficult to clarify how the central nervous system controls motor rhythmicity. Here, using a novel tempo-precision trade-off paradigm, we first modeled interindividual behavioral differences in tempo-dependent rhythmicity for various external tempi. We identified 2 behavioral extremes: conventional and paradoxical tempo-precision trade-off types. We then explored the neural substrates of these behavioral differences using task and resting-state functional magnetic resonance imaging. We found that the responsibility of interhemispheric motor network connectivity to tempi was a key to the behavioral repertoire. In the paradoxical trade-off type, interhemispheric connectivity was low at baseline but increased in response to increasing tempo; in the conventional trade-off type, strong baseline connectivity was coupled with low responsivity. These findings suggest that tunable interhemispheric connectivity underlies tempo-dependent rhythmicity control.
Effect of Malaria and Malaria Chemoprevention Regimens in Pregnancy and Childhood on Neurodevelopmental and Behavioral Outcomes in Children at 12, 24, and 36 Months: A Randomized Clinical Trial
Authors: Bangirana Paul , Conroy Andrea L , Opoka Robert O , Semrud-Clikeman Margaret , Jang Jeong H , Apayi Claire , Kakuru Abel , Muhindo Mary K , Georgieff Michael K , Dorsey Grant M , Kamya Moses R , Havlir Diane , John Chandy C 
Published: October 2022

Abstract

Background
Malaria in pregnancy has been associated with worse cognitive outcomes in children, but its association with behavioral outcomes and the effectiveness of malaria chemoprevention on child neurodevelopment are not well characterized.

Methods
To determine if more effective malaria chemoprevention in mothers and their children results in better neurodevelopment, 305 pregnant women were randomly assigned to 3 doses of sulfadoxine-pyrimethamine, 3 doses of dihydroartemisinin-piperaquine (DP), or monthly DP during pregnancy, and their 293 children were assigned to DP every 3 months or monthly DP from 2 to 24 months of age. Cognition, language, and motor function were assessed at 12, 24. and 36 months of age, and attention, memory, behavior, and executive function were assessed at 24 and 36 months of age.

Results
Children of mothers with versus without malaria in pregnancy had worse scores on cognitive, behavioral, and executive function outcomes at 24 months. Clinical malaria in children within the first 12 months was similarly associated with poorer scores in behavior and executive function at 24 months, language at 24 and 36 months, and motor function scores at 36 months. However, more effective malaria chemoprevention in the mothers and children was not associated with better outcomes.

Conclusions
Malaria in pregnancy was associated with worse cognitive, behavioral, and executive function scores in affected children, but more effective malaria chemoprevention measures did not result in better outcomes. Malaria chemoprevention prior to and early in gestation and with even higher efficacy in mothers and children may be required to prevent neurodevelopmental impairment in children.
Clinical Trials Registration. NCT02557425.
A contiguous de novo genome assembly of sugar beet EL10 (Beta vulgaris L.)
Authors: McGrath J Mitchell , Funk Andrew , Galewski Paul , Ou Shujun , Townsend Belinda , Davenport Karen , Daligault Hajnalka , Johnson Shannon , Lee Joyce , Hastie Alex , Darracq Aude , Willems Glenda , Barnes Steve , Liachko Ivan , Sullivan Shawn , Koren Sergey , Phillippy Adam , Wang Jie , Liu Tiffany , Pulman Jane , Childs Kevin , Shu Shengqiang , Yocum Anastasia , Fermin Damian , Mutasa-Göttgens Effie , Stevanato Piergiorgio , Taguchi Kazunori , Naegele Rachel , Dorn Kevin M 
Published: October 2022

Abstract
A contiguous assembly of the inbred ‘EL10’ sugar beet (Beta vulgaris ssp. vulgaris) genome was constructed using PacBio long-read sequencing, BioNano optical mapping, Hi-C scaffolding, and Illumina short-read error correction. The EL10.1 assembly was 540 Mb, of which 96.2% was contained in nine chromosome-sized pseudomolecules with lengths from 52 to 65 Mb, and 31 contigs with a median size of 282 kb that remained unassembled. Gene annotation incorporating RNA-seq data and curated sequences via the MAKER annotation pipeline generated 24,255 gene models. Results indicated that the EL10.1 genome assembly is a contiguous genome assembly highly congruent with the published sugar beet reference genome. Gross duplicate gene analyses of EL10.1 revealed little large-scale intra-genome duplication. Reduced gene copy number for well-annotated gene families relative to other core eudicots was observed, especially for transcription factors. Variation in genome size in B. vulgaris was investigated by flow cytometry among 50 individuals producing estimates from 633 to 875 Mb/1C. Read-depth mapping with short-read whole-genome sequences from other sugar beet germplasm suggested that relatively few regions of the sugar beet genome appeared associated with high-copy number variation.