bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disseminated rhinosporidiosis masquerading as soft tissue round cell tumour diagnosed by fine needle aspiration cytology
Authors: Balasubramaniam Vidhya Vikashini , Ramamoorthi Subhashini , Nadeem Naadia , Sekar Mithraa Devi , Gochhait Debasis , Siddaraju Neelaiah 
Published: September 2022

AbstractRhinosporidium seeberi belongs to the eukaryotic class Mesomycetozoea and causes chronic granulomatous lesions known as rhinosporidiosis. Rhinosporidiosis frequently involves the nasal cavity and nasopharynx through transepithelial invasion. Atypical presentations of this disease at other body sites have been reported, including the subcutis, visceral organs, bones, and genitals. Only a few cases of cutaneous and subcutaneous involvement have been reported to date. This chronic granulomatous condition is known for its recurrence following autoinoculation unless the correct diagnosis and appropriate treatment are given. We describe a case of an immunocompetent adult who had undergone fine needle aspiration cytology (FNAC) of mass‐like swellings in the right thigh and right calf at another healthcare centre and had been diagnosed with a small round blue cell tumour. FNAC at our centre confirmed a rare case of rhinosporidiosis that was clinically mimicking a soft tissue neoplasm of the lower extremity, and the erroneous interpretation of the prior cytology studies had resulted in misinterpretation of the individually dispersed pathogenic organisms as individual malignant cells. FNAC of rhinosporidiosis can lead to early diagnosis and prompt treatment of this pathogen when it presents at unanticipated body sites.
The Virus, the Dollar, and the Global Order: The COVID‐19 Crisis in Comparative Perspective
Authors: Hung Ho‐fung 
Published: September 2022

ABSTRACTIn 2003, the SARS pandemic led to a framework of global public health governance which was characterized by cooperation between the USA and China, and China's increasing influence in the World Health Organization. In the wake of the global financial crisis of 2008, major economies of the world, above all the USA, established the standard of aggressive fiscal and monetary expansion to mitigate any major crisis of the global economy. The effectiveness of such expansions in bringing global economic recovery without fuelling out‐of‐control inflation hinged on the deepening of US–China economic integration. These global health and economic governance frameworks, which emerged from two previous crises, conditioned the global response to the COVID‐19 pandemic in 2020. Ironically, the COVID‐19 crisis and the global responses to it undermined the legitimacy of the global public health governing institutions and further aggravated US–China rivalry, which had started before the pandemic. On the other hand, the crisis sustained economic integration between the two countries, despite the US–China trade war that began on the eve of the pandemic. This contradictory geopolitical and geo‐economic fallout of the COVID‐19 crisis will bring more uncertainty and instability to the global order in the wake of the pandemic.
Gene activation of metazoan Fox transcription factors at the onset of metamorphosis in the marine demosponge Amphimedon queenslandica
Authors: Yuan Huifang , Hatleberg William L. , Degnan Bernard M. , Degnan Sandie M. 
Published: September 2022

AbstractTranscription factors encoded by the Forkhead (Fox) gene family have diverse, sometimes conserved, regulatory roles in eumetazoan development, immunity, and physiology. Although this gene family includes members that predate the origin of the animal kingdom, the majority of metazoan Fox genes evolved after the divergence of animals and choanoflagellates. Here, we characterize the composition, structure, and expression of Fox genes in the marine demosponge Amphimedon queenslandica to better understand the origin and evolution of this family. The Fox gene repertoire in A. queenslandica appears to be similar to the ancestral metazoan Fox gene family. All 17 A. queenslandica Fox genes are differentially expressed during development and in adult cell types. Remarkably, eight of these, all of which appear to be metazoan‐specific, are induced within just 1 h of larval settlement and commencement of metamorphosis. Gene co‐expression analyses suggest that these eight Fox genes regulate developmental and physiological processes similar to their roles in other animals. These findings are consistent with Fox genes playing deeply ancestral roles in animal development and physiology, including in response to changes in the external environment.
Survival of individuals with cerebral palsy in Victoria, Australia: A longitudinal cohort study spanning four decades
Authors: Hinwood Gina L. , Loftus Hayley , Shepherd Daisy A. , Guzys Angela , Reddihough Dinah S. , Reid Susan M. 
Published: September 2022

AbstractAimTo provide an updated description of the rates, trends, and predictors of mortality of individuals with cerebral palsy (CP), born in the Australian state of Victoria between 1970 and 2012.MethodData were extracted for 4807 individuals (2091 females; 2716 males). The probability of survival to 30th June 2017 was calculated using the Kaplan–Meier method. Mortality rates were calculated per 1000 person‐years using age strata and compared with population mortality rates to produce mortality ratios. Cox proportional hazards regression was used to calculate hazard ratios for selected demographic and clinical characteristics and to estimate the effect of birth epoch on 15‐year survival.ResultsThere were 666 recorded deaths. Compared to the general population, mortality was higher for all persons with CP and highest for children aged 1 to 15 years (45–62 times). We observed 35% improvement in the probability of survival to 15 years for births in the 2000s relative to the 1970s (hazard ratio 0.65, 95% confidence interval [CI] 0.49, 0.86), but only 4% improvement for the subgroup with complex CP (hazard ratio 0.96, 95% CI 0.69, 1.33).InterpretationThe observed improvements in survival for those born in the 2000s is likely related predominantly to a proportional reduction in complex CP within the cohort.What this paper adds

Length of survival improved for Australians with cerebral palsy (CP) born this millennium.
Improved survival was mainly because of a proportional reduction in complex CP.
A small improvement in length of survival was seen for children with complex CP.
Delayed effects of neonatal immune activation on brain neurochemistry and hypothalamic–pituitary–adrenal axis functioning
Authors: Khantakova Julia N. , Bondar Natalia P. , Sapronova Anna A. , Reshetnikov Vasiliy V. 
Published: September 2022

AbstractDuring the postnatal period, the brain is highly sensitive to stress and inflammation, which are hazardous to normal growth and development. There is increasing evidence that inflammatory processes in the early postnatal period increase the risk of psychopathologies and cognitive impairment later in life. On the other hand, there are few studies on the ability of infectious agents to cause long‐term neuroinflammation, leading to changes in the hypothalamic–pituitary–adrenal axis functioning and an imbalance in the neurotransmitter system. In this review, we examine short‐ and long‐term effects of neonatal‐induced inflammation in rodents on glutamatergic, GABAergic and monoaminergic systems and on hypothalamic–pituitary–adrenal axis activity.
SMAD3 interacts with vitamin D receptor and affects vitamin D‐mediated oxidative stress to ameliorate cerebral ischaemia–reperfusion injury
Authors: Yu Hang , Xie Yuxiang , Dai Mingming , Pan Yuxiang , Xie Chengzhi 
Published: September 2022

AbstractCerebral ischaemia/reperfusion (I/R) injury is caused by blood flow restoration after an ischaemic insult, and effective treatments targeting I/R injury are still insufficient. Oxidative stress plays a critical role in the pathogenesis of cerebral I/R injury. This study investigated whether vitamin D receptor (VDR) could inhibit oxidative stress caused by cerebral I/R injury and explored the detailed mechanism. VDR was highly expressed in brain tissues of mice with cerebral I/R injury. Pretreatment with the active vitamin D calcitriol and synthetic vitamin D analogue paricalcitol (PC) reduced autophagy and apoptosis, improved neurological deficits and decreased infarct size in mice after cerebral I/R. Calcitriol or PC upregulated VDR expression to prevent cerebral I/R injury by affecting oxidative stress. Silencing of VDR reversed the protective effects of calcitriol or PC on brain tissues in mice with cerebral I/R. The bioinformatics analysis revealed that VDR interacted with SMAD family member 3 (SMAD3). It was validated through the chromatin immunoprecipitation assay that SMAD3 can bind to the VDR promoter and VDR can bind to the SMAD3 promoter. Collectively, these findings provide evidence that reciprocal activation between SMAD3 and VDR transcription factors defines vitamin D‐mediated oxidative stress to prevent cerebral I/R injury.
Ecumenical Theological Education in the Context of World Christianity
Authors: von Sinner Rudolf 
Published: September 2022

AbstractTheological education is facing a number of advances and setbacks. Among the advances are the globalization and transformation of Christianity, the evolution of communication tools, and the striving for formal theological education by groups that customarily shunned it as well as a generalized awareness for the contextuality of theological education. Setbacks can be seen in the reconfessionalization of theological education in many parts of the world and the end of significant ecumenical initiatives as well as the continuous difficulty of guaranteeing sustainability both to models of theological education and to the institutions that offer them. Mindful of these trends, this article seeks to provide a panoramic analysis of theological education in the context of an ever‐growing diversity of Christianity and to offer reflections and proposals on what is needed for a sustainable ecumenical and contextual theological education today.
Reconciliation with the Cosmos and Being New Creation
Authors: Anandan Chrisida Nithyakalyani 
Published: September 2022

AbstractAgainst the background of global issues such as climate change and the COVID‐19 pandemic and their effects on marginalized and oppressed communities, this article undertakes an ecological reading of 2 Corinthians 5:16‐21 in which justice, transformation, and participation play a key role for Paul. Such an ecological reading is also relevant in initiatives for education and ecumenical formation. Ecology and ecumenism are closely connected. With the realization that all human beings, creation, the earth, and earth communities are part of the renewed creation made out of reconciliation, the need to come together as churches, denominations, and faith communities becomes obvious. Ecumenical formation is a process of education and learning, and, at the same time, education is also the result of being ecumenical. It becomes directly relevant and connected to ecological justice. Education for self and for communities is an essential part of the churches’ ministry and responsibility to care for creation.
Christ’s Love (Re)moves Borders
Authors: Nalwamba Kuzipa 
Published: September 2022

AbstractA Global Ecumenical Theological Institute (GETI) was first held under that name in conjunction with the 10th Assembly of the World Council of Churches (WCC) in Busan, South Korea, in 2013, bringing together around 200 university‐level students and seminarians from churches around the world. It followed an earlier Ecumenical Congress held parallel to the WCC’s 9th Assembly at Porto Alegre, Brazil, in 2006, and was followed by a further GETI at the 2018 Conference on World Mission and Evangelism. This article presents the next instalment of GETI, being held in 2022 in conjunction with the WCC’s 11th Assembly in Karlsruhe, Germany. It situates GETI within the broader ecumenical historical trajectory, vision, and strategy for ecumenical formation and education, presenting it as a transformative pedagogical project that is grounded in ecumenical encounter and dialogue, what Paulo Freire has termed an epistemological relationship. The article further explores the theological rationale of the GETI 2022 theme, “Christ’s love (re)moves borders,” which is a derivative of the WCC’s assembly theme, “Christ’s love moves the world to reconciliation and unity.” In that regard, the theme locates GETI 2022 within the wider discourse of the WCC’s 11th Assembly. Finally, the article outlines the six thematic tracks of GETI 2022 in terms of how each explicates the theme and generates avenues for encounter and dialogue among participants in epistemological relationship. It concludes by underlining the value of nurturing critical awareness of, and reflection on, global issues as an act of passing on ecumenical memory to a new generation.
Despite Crises and Turmoil – High Time for Change
Authors: Weber Max 
Published: September 2022

AbstractIn August–September 2022, the WCC will gather in Karlsruhe, Germany, for its 11th Assembly around the theme “Christ’s love moves the world to reconciliation and unity.” In conjunction with the assembly, the Global Ecumenical Theological Institute (GETI) will bring together about 100 participants aged between 21 and 39 years to explore the theme “Christ’s love (re)moves borders.” Against the background of the GETI theme, this article explores some of the most pressing local and global issues. Based on these impressions, the author sets out his personal hopes and expectations for the GETI study programme and the WCC assembly in Karlsruhe.
Nucleosome disruption by 5‐bromodeoxyuridine leads to senescence
Authors: Guerrero Ana 
Published: September 2022

5‐Bromodeoxyuridine (BrdU) exposure leads to senescence, but the mechanistic details remain elusive. In this issue, En A et al. unveil a role of the HBR domain in histone H2B as a potential mediator of the effects of BrdU both in yeast and in human cells.Comment on: https://doi.org/10.1111/febs.16584
Fish processing waste: a novel source of non‐conventional functional proteins
Authors: Rana Sudha , Singh Arashdeep , Surasani Vijay Kumar Reddy , Kapoor Swati , Desai Ajay , Kumar Siddhnath 
Published: September 2022

SummaryFish waste has now become one of the serious problems worldwide, and its disposal without proper management could result in serious environmental pollution and nutrient loss. These wastes contain several biological and nutritional compounds, if recovered has a lot of promise. With the recent technological developments, many bioactive and functional compounds can be recovered from these wastes. The vast quantity of bioactive chemicals found in seafood processing by‐products has prompted the development of valorisation strategies for their extraction. The future of fish processing waste for reuse and bioconversion is bright with the right mindset and achieve progress in the future. Proteins have advanced significantly in recent years, piquing the interest of many academics around the world. Therefore, fish proteins can be extracted from the fish waste and can be further utilised for human and animal purposes in form of protein isolate, hydrolysate, gelatin, collagen, silage and fish meal.
mTORC1‐GLUT1‐mediated glucose metabolism drives hyperactivation of B cells in primary Sjogren's syndrome
Authors: Luo Xuan , Wu Xunyao , Wang Anqi , Chen Yingying , Peng Yu , Deng Chuiwen , Zhao Lidan , Yang Huaxia , Zhou Jiaxin , Peng Linyi , Wu Qingjun , Li Mengtao , Zhao Yan , Zeng Xiaofeng , Zhang Wen , Fei Yunyun 
Published: September 2022

AbstractPrimary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by B cell hyperactivation and hypergrammaglobulinemia. Currently, the role of metabolic pathways in the B cells of pSS patients is poorly defined. Here, we showed that upon cytosine phosphate‐guanine (CpG)/sCD40L/IL‐4 stimulation, B cells proportionally increased glycolysis and oxygen consumption, and compared with B cells from healthy controls (HCs), B cells from pSS patients exhibited higher glycolysis capacity and maximal oxidative respiration (OXPHOS). We also found that glucose transporter 1 (GLUT1) expression in B cells from pSS patients was significantly higher than that in B cells from HCs. Treatment with 2‐deoxy‐d‐glucose (2‐DG) inhibited the activation of B cells in pSS patients. Both 2‐DG and Metformin inhibited the proliferation, formation of plasma/plasmablasts and decreased the IgG and IgM levels in the supernatants of B cells from pSS patients. Furthermore, inhibition of mTORC1 by rapamycin had an effect similar to that of 2‐DG, suppressing B cell activation, proliferation and antibody production. Taken together, we demonstrated that B cells from pSS patients are more metabolically active than those from HCs and suggested that the mTORC1‐GLUT1 glycolysis pathways were the major drivers of B cell hyperactivation and autoantibody production in pSS patients.
Integrated long‐term care partnerships between government social care and health agencies in Brazil: The Belo Horizonte model
Authors: Lloyd‐Sherlock Peter , Giacomin Karla , de Carvalho Poliana Fialho , de Sousa Quesia Nayrane Ferreira 
Published: September 2022

AbstractThe article sets out key elements of the policy agenda for enhanced integration between health and social care for older people in high‐income countries and demonstrates its wider relevance to low‐ and middle‐income countries (LMICs). The article then explores the context for this agenda in Brazil, including growing demand for long‐term care (LTC) and current institutional arrangements. It goes on to discuss a case study project of partnering for LTC between local social assistance and health agencies in the Brazilian city of Belo Horizonte. It identifies challenges and potential benefits of this partnership model, offering policy insights for LTC policy in Brazil and other countries.
European Development Co‐operation via Technical Assistance: An Outside‐in Perspective
Authors: Shyrokykh Karina 
Published: September 2022

AbstractExisting research typically sees European Union (EU) development co‐operation as one of its tools for influencing third countries. By contrast, in focusing on technical assistance as a part of EU development co‐operation, this article examines third countries' influence on this co‐operation. The article builds on unique data on the EU's technical assistance to third countries and third countries' requests for technical assistance from the largest EU technical assistance instrument – the Technical Assistance and Information Exchange. The findings demonstrate that third countries are selective in the assistance that they request and that via such requests third countries can influence the extent of technical co‐operation with the EU. The article provides a novel outside‐in perspective on the EU's development co‐operation and contributes to our understanding of how the EU's technical assistance functions.
In Quest for Discursive Legitimation of Ongoing Policy Processes: Constructing Brexit as a Success Story
Authors: Brusenbauch Meislová Monika 
Published: September 2022

AbstractThe article brings together insights from the literatures on policy process, policy legitimation and legitimacy discourse to shed new light on the temporal structure of discursive legitimation of policy processes. It argues that in order to satisfy complex demands on their legitimacy, ongoing policy processes are legitimated not only by referring to the current state of affairs (status quo legitimation), but also by legitimating the future (status ad quem legitimation) and delegitimating the past (status quo ante delegitimation). Presenting an original typology of three distinct temporal regimes of policy process legitimation, this inquiry explores its validity on the empirical case of Brexit. Combining qualitative content analysis and the discourse‐historical approach (DHA) to discourse studies, the article elucidates how exactly Brexit was officially legitimated within the three temporal regimes by the UK Conservative government in 2021 – that is, during the first year of ‘full’ Brexit.
The stamp technique for direct restoration in a ICDAS 4 carious lesion: A 4‐year follow‐up
Authors: Vertuan Mariele , Mosquim Victor , Guimarães Genine Moreira de Freitas , Obeid Alyssa Teixeira , Bombonatti Juliana Fraga Soares , Ishikiriama Sergio Kiyoshi , Furuse Adilson Yoshio 
Published: September 2022

AbstractObjectiveThis case report described the use of a stamping technique associated with a bulk fill composite to restore an ICDAS 4 carious lesion on a posterior tooth. The 4‐year follow‐up is also presented.Clinical ConsiderationsA 32‐year‐old patient presented a carious lesion on tooth 36 with an underlying dark shadow at the dentin seen from the noncavitated enamel occlusal surface, which was compatible with an ICDAS 4 carious lesion. The lesion was radiographically detected and the caries disease was treated with dietary and hygiene habits orientations. Before accessing the lesion and selectively removing the carious tissue, an occlusal stamp was made by applying a flowable resin composite to copy the anatomy of the noncavitated enamel surface. The cavity was restored using a bulk fill resin composite (Opus Bulk Fill, FGM) with 4‐mm‐thick increments. Before curing the last increment, a Teflon band was adapted at the uncured bulk fill composite surface and the occlusal stamp made with the flowable composite was pressed against it to reproduce the natural characteristics and initial occlusal anatomy. The top surface was light‐activated for 40 s. After 4 years, small wear could be seen in the restoration, but still within clinically acceptable levels.ConclusionThe occlusal stamp technique allows reproduction of the natural anatomy of teeth affected by ICDAS 4 carious lesions with good clinical longevity over 4 years.Clinical SignificanceThis case report presents the use of the stamp technique to restore a tooth affected by an ICDAS 4 lesion, in which a carious process reached the dentin and the enamel anatomy was still preserved. The bulk fill resin composite associated with the occlusal stamp was chosen to quickly restore the cavity with clinical predictability. Bulk fill composites allow the insertion of up to 4‐mm‐thick increments and offer lower shrinkage stress, good clinical longevity and a less time‐consuming procedure in cases of posterior teeth, especially if associated with the stamp technique.