bluuebunny/crossref_metadata_2025_split huggingface dataset:
MODERN TECHNOLOGIES OF HYDROGEN GENERATION AND ACCUMULATION. ANALYTIC OVERVIEW OF THEORETICAL AND PRACTICAL EXPERIENCE
Authors: Boichenko S. , Shkilniuk I. , Tselishchev О. , Matviyi І. , Tarasiuk О. , Jaworski Artur , Wos Pawel 
Published: June 2022

The article discusses the competitiveness of alternative fuels and technologies in the rapidly growing segment of passenger vehicles and aviation, which globally consumes more than 70% of the fuel spent on passenger transportation and about 45% in total on transport. The emergence of new technologies in personal vehicles (electric vehicles, hydrogen cars with fuel cell, biofuels, natural gas, etc.) makes us look at the prospects for the development of this segment in a new way. On the basis of this approach, an assessment of the methods of hydrogen production was carried out. Hydrogen production by steam conversion of methane, water electrolysis and biochemical production methods were compared in this article.
Hydrogen is not a source of energy, but it is a mean of converting other energy sources into chemical energy in the form of accumulative pure hydrogen, which can be used subsequently during its oxigenation. In fact, a tank or other hydrogen storage device is technically similar to a battery or gas tank, and therefore it is necessary to compare not only the efficiency, but also other parameters. Hydrogen needs to be produced and converted to produce final energy, and both require energy.
The advantages of hydrogen as a universal energy carrier are determined by environmental purity, flexibility and efficiency of energy conversion processes with its participation. Technologies of large-scale hydrogen production are quite well mastered and have an almost unlimited raw material base.
The importance of hydrogen production technologies is determined by the high calority of hydrogen combustion and the possibility of reducing greenhouse gas emissions, since ordinary water is the combustion product.
The article provides a comparative analysis of methods of hydrogen storage in liquid and gaseous states, carbon structures and hydride of metals
The Isotope Composition, Nature, and Main Mechanisms of Formation of Different Types and Subtypes of Salt Lakes in Transbaikalia
Authors: Borzenko S.V. , Zamana L.V. , Posokhov V.F. 
Published: June 2022

Abstract
—More than a hundred lakes, groundwater, rivers, and precipitation of their catchments have been studied in Transbaikalia. The chemical composition of natural waters and the mineral composition of rocks and lacustrine bottom sediments have been analyzed. The isotope composition of waters, the isotope ratios in dissolved and deposited carbonates and in bacterial mats, and the content of heavy oxygen in the aluminosilicate fraction of bottom sediments and rocks in catchments have been determined. It is shown that all secondary minerals inherit the oxygen isotope composition of water, but their oxygen is isotopically much heavier than the water oxygen, because the water–rock interaction leads to the fractionation of oxygen and the transition of its heavy isotope into secondary carbonates and aluminosilicates. Bacterial mats using oxygen of carbon dioxide ions for their vital activity are also enriched in its heavy isotope. We have established that the water of soda lakes, being less saline than other lake waters, is more enriched in heavy oxygen isotope. Mineral analysis of lacustrine bottom sediments and material from sedimentation traps revealed chemogenic carbonates and secondary aluminosilicates. The performed thermodynamic calculations confirm their possible formation in lakes. It is shown that the lake water is in equilibrium not only with carbonates, clays, and hydromica but also with zeolites, and the most alkaline and mineralized water is in equilibrium with albite. The bottom sediments of soda lakes have a greater portion of clays and carbonates than those of fresh, chloride, and sulfate waters. The enrichment of salt lake waters with heavy isotopes is due not only to evaporation but also to the water–rock interaction. The contribution of aluminosilicate hydrolysis to oxygen fractionation is confirmed by the direct dependence of the “oxygen shift” value on pH, whose value is determined by the degree of the above interaction. We have established that the diversity of the chemical and isotope compositions of lake waters is due to their multifactorial formation related to the different degrees of lake water evaporation, the different mineralization of organic matter, and the different duration of the interaction of lake waters and groundwater with rocks.
The Ambiguous "Internal Carotid Artery" - Ultrasound Diagnosis of One Case of Congenital Absence of the Internal Carotid Artery
Authors: Zhong Gang , Ning Jing , Long Xiangdang , Xie Juanjuan , Ao Kun , Liu Fang , Huang Mengyi , Zhuo Yu , Li Qiaorong , Wen Qiongli , Di Qiuyi 
Published: June 2022

Abstract
Background: Congenital absence of the internal carotid artery (ICA) is a very rare congenital anomaly of the ICA. Most reports in the literature are of individual cases, and most were diagnosed by computed tomographic angiography (CTA) or digital subtraction angiography (DSA). There are few reports on the diagnosis of congenital absence of the ICA by carotid Doppler ultrasound (CDUS). Case presentation: A 61-year-old male patient who was admitted to the hospital because of dizziness and showed no abnormality on CDUS conducted at another hospital. CDUS conducted at our hospital found maldevelopment of the right common carotid artery (RCCA) with normal a blood flow velocity and spectrum. A high-resistance frequency spectrum could be detected in the “ICA” that continued directly from the RCCA, and two adjacent small blood vessel branches were also observed. Superficial temporal artery tap and tracing of the courses of the small blood vessels confirmed that the RCCA directly continued to the external carotid artery (ECA). The final diagnosis was congenital absence of the ICA, which was confirmed during the clipping of an anterior communicating artery (ACoA) aneurysm.Conclusion: CDUS, as a noninvasive and rapid screening tool for cervical vascular diseases, offers a new approach for the diagnosis of congenital absence of the ICA.
Immune Checkpoint Inhibitor Induced Vitiligo in Non-Melanoma Patients: Characterization and Management
Authors: Lo Jonathan , Hanania Hannah , Keiser Monika , Patel Anisha 
Published: June 2022

Abstract
Immune checkpoint inhibitors (ICIs) are being used to treat a growing variety of metastatic cancers. With this increased cancer heterogeneity, there is increased patient diversity. Vitiligo is one of the earliest cutaneous adverse events (CAEs) reported with this class of medications and can have a significant psychosocial and quality of life impact on patients, in particular skin of color patients. Although ICI-associated vitiligo is a known CAE, little has been reported about the course, prognosis, and management of this disease. This single-institution, retrospective study of 151 consecutive patients with ICI-induced vitiligo was conducted using the natural language processing and the electronic medical record. Results highlight the various cancer types associated with immune checkpoint inhibitor-induced vitiligo. Our cohort had mostly melanoma patients (132, 87.4%), with the most prevalent race overall being Caucasians (108, 71.5%). Our cohort of 19 (12.6%) non-melanoma patients, however, definitively challenges the previously held notion that ICI-induced vitiligo is limited to melanoma patients. Specifically, ICI-induced vitiligo in patients with angiosarcoma, Hodgkin’s lymphoma, and mycosis fungoides were not previously reported in the literature. We noted that non-melanoma patients had a statistically significant difference (p = 0.005) in median time to onset of vitiligo compared to melanoma patients with 382 days versus 209 days, respectively. Vitiligo outcomes in our cohort showed 117 patients (78%) had stable disease, while 26 (17.3%) worsened and 7 (4.7%) improved. This supports vitiligo as a predominantly non-progressive CAE. Further, potential management options including successful repigmentation with standard of care narrowband ultraviolet light B and topical corticosteroid therapy are anecdotally demonstrated in three patients. This study emphasizes the potential impact of this disease on the growing population of patients at risk of ICI-induced vitiligo as well as the potential for effective treatment.
Application of pedicled greater omentum flap tamponade combined with laparoscopic fenestration in diaphragmatic hepatic cyst
Authors: Wu Zujian , Chen Yun , Jin Ye , Liu Changfeng , Liu Yusu , Zhang Bing 
Published: June 2022

Abstract
Objective To investigate the efficacy and clinical application advantage of omental tamponade with vascular pedicle combined with Laparoscopic fenestration for the treatment of diaphragmatic hepatic cyst. Methods A total of 56 patients with diaphragmatic hepatic cysts underwent laparoscopic surgery in a single tertiary academic medical center from January 2010 to October 2020, including 21 patients (non-omental group) underwent laparoscopic fenestration of liver cysts, and 36 patients underwent laparoscopic liver cyst fenestration combined with vascular pedicle omentum tamponade (omental group). The general conditions and follow-up results of the two groups were compared and annalyzed.Results The operation time of the omental group was longer than that of the non-omental group (P = 1.358E-4). There was no significant difference in postoperative complications, postoperative laboratory values, hospital stay and hospital costs (P＞0.05). In the omental group, recurrence occurred in 1 of 35 patients (4.65%) who were followeded up 12 months after surgery. In the non-omental group , of the 21 patients followed, 8 patients (38.10%) recurred 12 months after surgery, and 3 patients (14.28%) recurred 6 months after surgery.Conclusion It is an effective method to prevent the recurrence of diaphragmatic hepatic cyst after laparoscopic fenestration by packing the cyst with vascularized omentum.
Adherence to combined exercise and dietary intervention in patients with gastrointestinal cancer undergoing neo-adjuvant therapy: an open-label, pilot, randomized controlled trial.
Authors: Velho Sónia Denise Ferreira , Moço Sara , Capitão Carolina , Branco Mariana , Costa Luísa , Rodrigues Sílvia , Abreu Claudia , Pires Filipa , Sousa Pedro , Agostinho Lisa , Cruz Rita , Clemente Susana , Borges Ana , Lopes Fábio , Godinho João , Faria Ana , Teixeira José Alberto , Coelho José Luís Passos , Maio Rui , Baracos Vickie E , Cravo Marilia Lopes 
Published: June 2022

Abstract
BackgroundTo assess adherence of gastrointestinal cancer patients to a Combined Exercise and Dietary Intervention (CEDI) during neo-adjuvant chemotherapy.MethodsParallel randomized controlled, open label, pilot trial. A table from a web based randomization system was used to allocate treatments. 46 patients were screened at diagnosis of esophageal, gastric, pancreatic and rectal cancer from June 2018 to November 2019 at a teaching hospital in Loures, 39 were randomized. A planned interim analysis was performed and results are herein presented. Patients were randomized to receive either 8 week individualized CEDI, with moderate aerobic and resistance training, dietary counseling and oral nutritional supplements or standard care. Follow up was conducted after neo-adjuvant treatment. Main outcome measures were adherence to CEDI, change in weight, body composition and functional status. Adherence to CEDI was analyzed with an intention to treat approach, other outcome measures were analyzed with a per protocol approach. Data analysis was conducted with Chi-square test or Fisher exact test and t-test or Mann Whitney U test. Effect size was computed with Cohen’s d for t tests and r for Mann-Whitney U tests. Paired-samples t test or Wilcoxon Signed Rank Test were used to analyze longitudinal data.Results39 patients (CEDI n = 19 or control n = 20) were randomized and included in the intention to treat analysis (29 (74.3%) male, median age 63.5 (Interquartile Range (IQR):11.75)). 32 patients completed follow up. 13/19 (68.4%) were fully adherent to CEDI. CEDI patients maintained weight (Effect size (EF):0.457; 95% Confidence Interval (95%CI): [0.44,0.46]), waist circumference (EF:-0.56, 95%CI: [-1.08, -0.034]), had a lower skeletal muscle loss (EF:-0.79; [-1.77;0.18]) and improved 6 minute walking test distance (EF:-1.51; 95%CI: [-2.57;-0.44]) and quality of life function score (EF:0.45; 95%CI:[0.43,0.45]). There were 4 serious adverse events, 3 in theintervention and 1 in the control arm but none related to the intervention.ConclusionsCEDI is feasible and patients are willing to participate even under neo-adjuvant chemoradiotherapy, resulting in potential nutritional and functional benefits.Trial registrationTrial registry: www.clinicaltrials.gov; Identifier: NCT05237921, 14-2-22, retrospectively registered, https://www.clinicaltrials.gov/ct2/results?cond=&term=NCT05237921&cntry=&state=&city=&dist=
TSGA10, a new player in regulating autophagy and apoptosis
Authors: Rezazadeh Davood , Ranjbarnejad Fatemeh , Mansouri Kamran , Mostafaie Ali , Barzegari Ebrahim , Modarressi Mohammad Hossein 
Published: June 2022

Abstract
Testis specific gene antigen 10 (TSGA10) overexpression could inhibit angiogenesis and tumor cell proliferation, migration and invasion through inhibiting HIF-1α. The exact role of TSGA10 in autophagy and apoptosis is not clear. Present study was conducted to investigate the potential effects of TSGA10 overexpression on regulation of autophagy and apoptosis. To do so, TSGA10-containing vector (pcDNA3.1-TSGA10 vector) was designed for stable and transient transfections in HeLa cells, and clonal selection was applied. Expression of autophagy and apoptosis-related genes was assessed by real-time RT-PCR in TSGA10-overexpressing cells compared with HeLa cells transfected by empty vector. Rate of autophagy and cell viability were assessed by acridine orange and MTT assays, respectively. Our findings showed that overexpression of TSGA10 would induce autophagy under normoxic and hypoxic conditions in the presence or absence of autophagy inducers. Expression levels of autophagy and apoptosis-related genes increased significantly in TSGA10-overexpressing cells compared with control cells. In addition, HeLa cells overexpressing TSGA-10 exhibited lower expression of BCL-2 and survival rates in comparison with control cells. Molecular docking results showed that interaction between TSGA10 and BCL-2 could inhibit anti-apoptotic activity of BCL-2. According to our findings, TSGA10 overexpression has a main role in regulating autophagy and apoptosis through inhibition of BCL-2. Therefore, TSGA10 could be considered as a new regulator of autophagy and apoptosis in future studies.
AHP-Entropy-WASPAS Technique for Performance Evaluation of Agricultural Surface Water Distribution Systems Based on Water-Food-Energy Nexus
Authors: Bayat Fatemeh , Roozbahani Abbas , Shahdany Seied Mehdy Hashemy 
Published: June 2022

Abstract
This study aimed to quantitatively evaluate the performance of practical alternatives in modernization projects of surface water distribution systems in irrigation networks based on the water-food-energy nexus using the AHP-Entropy-WASPAS technique. Three methods of improved manual operation, decentralized automatic operation, and centralized automatic operation were developed under normal and water shortage operation scenarios and modeling the current status of water distribution in the main canal of the Isfahan Rudasht irrigation network as a case study. Water-based indicators (i.e., surface water delivery, surface water productivity, and surface water economic productivity), energy-based indicators (i.e., energy consumption, energy productivity, and economic energy productivity), and food-based indicators (i.e., food productivity and food economic productivity) were used to develop the nexus evaluation framework. The results showed that the average values of the water-food-energy nexus index in the manual operation method were estimated at 0.49 and 0.16 under normal and water shortage operation scenarios, respectively. These average values were estimated at 0.53 and 0.17 under normal and water shortage operation scenarios, respectively, by improving the method to the improved manual operation method. The decentralized automatic operation method improved these average values to 0.82 and 0.39 under normal and water shortage operation scenarios. Finally, using the centralized automatic operation method, these average values were 0.94 and 0.35 under normal and water shortage operation scenarios. Since the downstream secondary off-takes of the irrigation network receive no water even by upgrading the surface water distribution system to the decentralized automatic operation method under the water shortage operation scenario, it can be said that the performance of the centralized automatic operation method is more efficient than the decentralized automatic operation method due to the fair and uniform distribution of water in both normal and water shortage operation scenarios.
Comparing critically-ill ARDS patients with versus without COVID-19: Prospective analysis of 690 patients
Authors: Algethamy Haifa M , Aboudeif Mohammed M , Alhandi Moatz O , Majrashi Fahd Y , Hakami Shrooq H , Jan. Midhat A , Kabli Hanan A , Alhomrani Mohammed H , White Kevin P. 
Published: June 2022

Abstract
BACKGROUND
Few studies have directly and prospectively compared ICU patients with acute respiratory distress syndrome (1) caused by COVID-19 versus other causes, almost all previously-published studies retrospective and employing historical non-COVID cases. This study aimed to identify patient characteristics and predictors of mortality associated with COVID-related ARDS.
METHODS
We performed a Prospective cohort study. Consecutive ARDS patients with versus without confirmed COVID-19 admitted to a single ICU of a major tertiary-care hospital from March-December 2020 were included. Data were collected and both bivariate and multivariable analysis performed on COVID-19 status, demographics; morphometrics; comorbidities; presenting symptoms; admission general health status (APACHE-II); respiratory and laboratory tests at admission, within 24 hours of admission, and pre-intubation; treatments administered; and outcomes. Data capture was almost 100%.
RESULTS
Numerous clinical differences were detected between n = 160 patients with versus n = 530 patients without COVID-19. Most notably, COVID-19 patients were generally older and heavier, much more frequently presented with fevers/chills, dyspnoea, cough, anosmia/ageusia, and sore throat — and had worse outcomes, including over a two-fold rate of mortality and five-fold rate of survivors requiring prolonged supplemental oxygen. The presenting symptom dyad of fevers and/or chills and dyspnoea was 93.0% sensitive and 63.4% specific for COVID-related ARDS. A baseline APACHE-II Score ≥ 17 and requiring mechanical ventilation was 94.4% sensitive and 70.5% specific for mortality. All 37 COVID patients with an APACHE-II score > 30 died, versus survival among non-COVID patients with APACHE-II scores up to 40.
CONCLUSION
In one of the first large studies to directly compare contemporary populations of COVID-19 and non-COVID ICU patients with ARDS, employing multi-variable analysis, numerous differences in patient characteristics, presentation, and outcomes were detected.
The Clinical Characteristic and Management of patients with nocardiosis in a tertiary hospital in China
Authors: Liu Peilin , Wang Zhiqian , Jian Zijuan , Liu Xuan , Li Yanming , Yan Qun , Zhong Baiyun , Liang Xianghui , Liu Wenen 
Published: June 2022

Abstract
Background
Nocardiosis is an uncommon opportunistic bacterial infection caused by Nocardia spp., and its incidence has increased significantly in recent years. This study aimed to summarize the clinical characteristics and management of nocardiosis to provide a reference for clinical diagnosis and treatment.
Methods
This retrospective study was conducted based on the medical records of nocardiosis patients between January 2015 and December 2021 in a tertiary hospital in China.
Results
Overall, 44 patients with nocardiosis were included in this analysis including 26 males and 18 females with a mean age of 50.4 ± 13.2 years. Connective tissue disease (CTD) was the most common underlying disease (16/44). Twenty-six patients were given immunosuppressive therapy. The most frequent infection sites were the lungs (17/44) and skin and soft tissue (8/44). Common symptoms included cough (23/44), expectoration (18/44), fever (15/44), and subcutaneous abscesses (15/44). Average microbiology laboratory detection time was 4.8 days. Twenty-nine patients were managed only with antimicrobial treatment, and 14 patients received both antimicrobial and surgical therapies. Trimethoprim-sulfamethoxazole (TMP-SMX) was the most commonly used antibiotic (31/44). Thirty-five patients were cured or improved, 6 patients were discharged from the hospital due to poor prognosis, and 1 patient died.
Conclusion
Clinicians should be alert to immunocompromised patients, especially those with CTD, and tend to pulmonary or cutaneous infections. Smear microscopic examination and prolonged culture time may aid Nocardia identification. Patients with nocardiosis can be treated with antimicrobials or surgical therapy. TMP-SMX remains the mainstay treatment, and its early and prompt use may improve nocardiosis outcome.
Friction and Pore-Fluid Pressure Conditions in Faults Controlling Earthquake Rupture Dynamics
Authors: Tsuda Kenichi , Hirono Tetsuro 
Published: June 2022

Abstract
Although direct recovery of frictional features of fault rocks through drilling projects and multiple experimental analyses such as the Japan Trench Fast Drilling Project (JFAST) and the Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE) been recently performed, the conditions of rupture propagation to levels of friction and pore-fluid pressure remains uncertain. In order to try to invest such issues, we performed dynamic rupture simulations based on experimental friction datasets measured in fault rocks on the Nankai Trough that was ruptured during the 1944 Mw8.0 Tonankai earthquake. A steady-state friction triggered large slip (about 30 m) near the trench, whereas a high friction suppressed the rupture. The environmental condition in which the pore-fluid pressure was nearly equal to the lithostatic stress decreased the slip about 25 m in case of low friction. However, in case of high friction with negative stress drop, the slip reached about 20 m because the low shear strength did not arrest the inertial motion of rupture propagation. Such differences in fault-rock properties and fluid conditions may fundamentally influence on the complexity and the variability of rupture propagation