bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Hydration 1 Hour After Extubation Is Safe And Effective In Cardiac Surgery Patients: A Randomized Trial
Authors: Liang Ting , Li Sailan , Peng Yanchun , Chen Qi , Chen Liangwan , Lin Yanjuan 
Published: March 2022

Abstract
Background: Cardiac surgery patients are at a risk of postoperative nausea, vomiting, and aspiration pneumonia, but conventional 4–6-h fasting can exacerbate thirst. Early oral hydration is recommended, but the post-extubation time for intervention remains unclear. This study aimed to investigate the effects of early thirst management on thirst, the oral environment, gastrointestinal adverse reactions, and aspiration pneumonia in cardiac surgery patients.Methods: A total of 84 cardiac surgery patients were randomly divided into two groups for either conventional oral hydration or early oral hydration. The primary outcome was thirst intensity. The secondary outcomes were adverse gastrointestinal reactions (nausea and vomiting), aspiration pneumonia, unstimulated saliva flow rates, salivary pH, oral odor, oral mucosal moisture, and patients' satisfaction. At 1 h post-extubation, patients were evaluated for thirst intensity and intervention readiness. Patients who passed the evaluation were subjected to thirst management. Results: The patient demographic and clinical characteristics did not significantly vary between the groups. The scores for thirst (3.38 versus 8.24，F=306.21, P＜0.001), oral mucosa (2.03 versus 3.90, P＜0.001), halitosis (2.77 versus 3.76, P＜0.001) were significantly lower in the early oral hydration group than in the conventional oral hydration group. The early oral hydration group was associated with significantly higher salivary pH (6.44 versus 0, P＜0.001), unstimulated saliva flow rates (0.18 versus 0, P＜0.001) and patient satisfaction (4.28 versus 3.15, P＜0.001) than the conventional oral hydration group. Gastrointestinal adverse reactions did not significantly vary (7.70% versus 4.88%, P=0.60), and aspiration pneumonia was not observed in both groups.Conclusion: The early oral hydration significantly alleviated thirst, stabilized the oral environment without exacerbating gastrointestinal adverse reactions and aspiration pneumonia, and increased patient satisfaction.Trial registration: Chinese Clinical Trial Registry: ChiCTR2100049206. Registered 25 July 2021.
Associations between Diet History and Symptoms in Covid-19 Recovered People
Authors: sahloul ola , Sahlou Talaat M. 
Published: March 2022

Abstract
Most prior studies confirm that people who eat a balanced diet have stronger immunity. The current study aimed to identify the effect of the diet history of COVID-19 patients recovered from occurring symptoms and their severity. The study sample consisted of 346 people aged 20–65 years. The study includes (personal data and an electronic questionnaire for getting diet history and the kinds of symptoms). Then the study focused on four hardness symptoms (fever, body pain, cough, and dyspnea) to find a relationship between them and some immunity foods. In this study, we can conclude that:-Intake of some functional foods slightly affected the reduction of symptoms occurring in compared with those who did not eat any of these foods by using averages of their percent, which was 88.1% suffered from symptoms in the case of no intake of these foods, compared with symptoms in cases of little and intensive intake, which were 85.54% and 85.55%, respectively.
Assessing Community Perception on Climate Change and variability, Its Impacts and adaptation strategies in Anlemo woreda, Hadiya zone SNNPR
Authors: Ersino Alemu 
Published: March 2022

Abstract
The study assessed the rural community perception of climate change and variability, its impacts, and adaptation strategies in Anlemo woreda. The study was used purposive sampling techniques to select woreda and both kebeles. The sizes of the sample household respondents were 191 out of each, 30 participants were female-headed households. Both qualitative and quantitative methods of data collection and analysis were used. A time-series analysis was used to show the trend of temperature and rainfall. The researcher used the Coefficient of variation and percent of deviation to discern rainfall variability. The findings of the study showed that both maximum and the average temperature had increased, belg rainfall had decreased, whereas annual and Meher rainfall had increased and showed inter-annual and seasonal variation. The researchers also showed that the district is experiencing increasing land degradation, spatially soil erosion, nutrient depilation, and deforestation are perceived as impacts of climate variability. The results revealed that most of the people perceived long-term variability in the pattern of rainfall amount and distribution and an increasing trend and variability of temperature. Therefore, farmers are undertaking different adaptation and coping mechanisms. Providing training, increasing accessibility to infrastructure, the credit services market, and introducing new technologies are forwarded as recommendations.
Status of the health information system in Ireland and its fitness to support health system performance assessment: A multimethod assessment based on stakeholder involvement
Authors: Ivanković Damir , Jansen Tessa , Barbazza Erica , Fernandes Óscar Brito , Klazinga Niek , Kringos Dionne 
Published: March 2022

Abstract
Background
A major 10-year health reform, called Sláintecare, was launched in Ireland in 2017 with aims of improving health system performance, governance and accountability, while achieving universal health coverage. To support the implementation of the reform, the Irish Department of Health requested technical support from the European Union in developing a health system performance assessment (HSPA) framework. An external team of researchers was contracted to work in close collaboration with the Irish health authorities on the “Performance accountability for the Irish health system” project. Between September 2019 and March 2021, a pilot HSPA framework for Ireland was developed and officially launched in September 2021. Routinely collected health data are needed to populate indicators in the HSPA framework. Considering the pivotal role of data, in this scope, an assessment of the health information system (HIS) in Ireland and its fitness to support the implementation of an HSPA framework was conducted, involving a broad range of stakeholders.
Methods
Between May and November 2020, over 50 informants were engaged in key informant interviews and multi-stakeholder consultation workshops as part of the HIS assessment and the broader HSPA project. Descriptive themes and data availability heatmaps were derived from interview data using thematic analysis. Indicator “passports” for the HSPA framework were populated during stakeholder consultation workshops.
Results
The HIS in Ireland was able to provide administrative, survey and registry-based data for public sector acute care services, focusing on structure, process and output metrics. Significant data availability gaps, most notably from primary care, private hospitals and community care were reported, with little availability of electronic health record and people-reported data. Data on outcome metrics were mostly missing and so were data linkage possibilities. The COVID-19 pandemic emphasised the national HIS’s shortcomings but also capacity for rapid development and improvement.
Conclusions
Assessment of the HIS in Ireland contributed to the development of a national HSPA framework but also created a momentum to further strengthen data infrastructure and governance and work towards a more data-driven and person-centred health care system.
A Trust Region Based Local Bayesian Optimization without Exhausted Optimization of Acquisition Function
Authors: Li Qingxia , Fu Anbing , Wei Wenhong , Zhang Yuhui 
Published: March 2022

Abstract
Bayesian optimization (BO) is an effective optimization technique for solving expensive black-box problems. Even though BO has remarkable success, its drawbacks are also obvious. First, the time complexity of the Gaussian process inference is higher than O(n3), where n is the number of samples. Consequently, the running time of BO increases rapidly with the problem size. Second, due to the non-convexity and multimodality of the acquisition function, it costs a lot to achieve good results. To address the above problems, we develop a local Bayesian optimization algorithm based on the trust region idea (TRLBO). In TRLBO, two trust regions with dynamically changing sizes are used to enhance the algorithm’s exploitation ability, while at the same time retaining the exploration ability. Specifically, one trust region is used to reduce the number of samples in the Gaussian process. The other is used to restrict the solution space of the candidates. Furthermore, some theoretical results were provided to enlighten the efficiency of the proposed algorithm. Experimental results on both benchmark functions and real-world problems show that TRLBO compares favorably with the state-of-the-art algorithms.
Dynamic Explicit Analysis and Prediction of Compressive Damage effects
Authors: touolak benedicte touogam 
Published: March 2022

Abstract

In this paper, the nonlinear finite element analysis by ABAQUS was used to predict the behavior and ultimate capacity of shaft lining steel-concrete composite structures. The numerical data for designing the shaft lining structure in coal mines; the stress-strain response and damage of steel-concrete composites is deeply explore through finite element analysis and analytical methods. The present work studies the influence of thickness-diameter ratio on the shaft lining structures performance by focusing on the stress-strain characteristics, geometry imperfections, damage and deformations occurs inside the materials structure properties. The results from the finite element simulation agree very well with the experimental observations, especially with regard to load-deflection response, crack patterns at different load stages, failure modes and stress-strain mechanisms. All these indicate that the constitutive models used for shaft linings concrete by ABAQUS are able to capture compressive behavior and stress-strain response of the different Z1, Z2, Z3, Z4, Z5, Z6, Z7, Z8, and Z9 specimens.
Transcranial electrical stimulation effects on neurovascular coupling
Authors: Arora Yashika , Dutta Anirban 
Published: March 2022

Abstract
Transcranial electrical stimulation (tES) can exert cerebrovascular effects, but the mechanisms are unclear. Long-term (≥3min) transcranial direct current stimulation (tDCS) can also change the extracellular ion concentrations that can modulate neuronal excitability. An increase in interstitial K+ can modulate the neurovascular system's sensitivity via Kir channels in the astrocytes and the mural cells.To gain a mechanistic understanding of the tES effects on neurovascular coupling (NVC), we used a physiologically constrained multi-compartmental model (having nested pathways) for modal analysis to study the dynamic properties of the system for the output changes in blood vessel circumference and their natural frequencies in the frequency domain. Then, we used the open-source rsHRF toolbox and the functional magnetic resonance imaging (fMRI)-tDCS dataset to show the effects of anodal tDCS on hemodynamic response function (HRF) in the grey matter and at three regions of interest in the grey matter underlying anodal electrode (FC5), cathodal electrode (FP2), and an independent site remote from the electrodes (PZ). A canonical HRF model and a Finite Impulse Response (FIR) model captured the anodal tDCS effects on the temporal profile of the HRF. The modal analysis characterized the tES's vascular effects through neuronal and non-neuronal pathways, where stable modes were found for the smooth muscle cell compartment in the 0Hz-0.05Hz range.Our study showed tDCS onset effects on the neurovascular coupling (and HRF) for verum and sham tDCS conditions that were different from the no tDCS condition, which questions the validity of the placebo. Therefore, it is crucial to avoid fitting a common HRF for the whole brain, and disentangling the tES effect on the HRF is critical to the fMRI-tES studies. Future studies also need to address the trade-off between bias (in canonical HRF) and variance (in FIR HRF) that can be achieved by applying a mechanistic grey-box model.
Time-restricted eating to address cancer-related fatigue among cancer survivors: A single-arm pilot study
Authors: Kleckner Amber S. , Altman Brian J. , Reschke Jennifer E. , Kleckner Ian R. , Culakova Eva , Dunne Richard F. , Mustian Karen M. , Peppone Luke J. 
Published: March 2022

Abstract
Purpose
Cancer-related fatigue is a prevalent, debilitating condition that can persist for months or years after treatment. In a single-arm clinical trial, the feasibility and safety of a time-restricted eating (TRE) intervention were evaluated among cancer survivors, and initial estimates of within-person change in cancer-related fatigue were obtained.
Methods
Participants were 4–60 months post-cancer treatment, were experiencing fatigue (≥ 3 on a scale 0–10), and were not following TRE. TRE entailed limiting all food and beverages to a self-selected 10-h window for 14 days. Participants reported their eating window in a daily diary and completed the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), Brief Fatigue Inventory (BFI), and symptom inventory pre- and post-intervention.
Results
Participants (n = 39) were 61.5 ± 12.4 years old and 1.8 ± 1.3 years post-treatment; 89.7% had had breast cancer. The intervention was feasible in that 36/39 (92.3%) of participants completed all questionnaires and daily diaries. It was also safe with no severe adverse events or rapid weight loss (average loss of 1.1 ± 2.3 pounds, p = 0.008). Most adhered to TRE; 86.1% ate within a 10-h window at least 80% of the days, and the average eating window was 9.33 ± 1.05 h. Fatigue scores improved 5.3 ± 8.1 points on the FACIT-F fatigue subscale (p < 0.001, effect size [ES] = 0.55), 30.6 ± 35.9 points for the FACIT-F total score (p < 0.001, ES = 0.50), and − 1.0 ± 1.7 points on the BFI (p < 0.001, ES=-0.58).
Conclusion
A 10-h TRE intervention was feasible and safe among survivors, and fatigue improved with a moderate effect size after two weeks. This study supports evaluation of TRE in randomized controlled trials to address persistent cancer-related fatigue.
Trial registration:
This study was pre-registered at clinicaltrials.gov under number NCT04243512 in January 2020.
The inhibition of proliferation and invasion of human colon carcinoma cell line (Caco-2 cells) by cell-free supernatants from Lactobacillus Rhamnosus and Lactobacillus Acidophilus
Authors: Abroun Saeid , Shokati Ameneh , Soleimani& Masoud 
Published: March 2022

Abstract
Background: The epidemiological studies indicated that colorectal cancer is one of the most common types of cancer in the world and is considered a leading cause of cancer-related death. The present study aimed to investigate the inhibitory effect of lactobacillus acidophilus(PTCC 1643) supernatant (LAS) and lactobacillus rhamnosus (PTCC 1657)supernatant (LRS) on the growth and invasiveness of the human colon carcinoma cell line (Caco2) in-vitro. Methods: In this experimental study, the anti-proliferative activity and anti-invasion potential of LAS and LRS were determined by MTT and transwell chambers assays, respectively. The expression of mitochondrial membrane potential-9 (MMP-9) and matrix metalloproteinase-12 (MMP12) genes were analyzed by real-time PCR.Results: The results indicated that supernatants of these two lactobacilli had cytotoxic effects on Caco-2 cells at a concentration of 25% v/v and higher. Thus, the minimum concentrations (25% V/V) of supernatants were chosen for further experiments. LAS and LRS could significantly suppress the invasiveness of Caco-2 cells. Also, the expression of MMP12 was significantly increased in Caco-2 cells when treated with LAS, whereas LRS had no significant effect on the invasive capacity and the gene expression levels of MMP12. The expression of MMP-9 was statistically decreased in Caco2 cells treated with LAS and LRS (P<0.00001).Conclusion: In general, it was shown that LAS and LRS exert anti-cancer activity against the growth, invasion, and metastasis of Caco2 cells in-vitro. It seems that these two bacteria could be used as prophylactic and therapeutic agents for the prevention and treatment of colorectal cancer.
Paracelsus 10,000: A prospective cohort study based on the population of Salzburg, Austria. Rationale, objectives and study design
Authors: Frey Vanessa , Langthaler Patrick , Raphaelis Emanuel , Ring-Dimitriou Susanne , Kedenko Ludmilla , Aigner Elmar , Martinz Jennifer , Gostner Isabella , Bathke Arne , Fartacek Reinhold , Sungler Paul , Studnicka Michael , Haschke-Becher Elisabeth , Trinka Eugen , Iglseder Bernhard , Paulweber Bernhard 
Published: March 2022

Abstract
Background
Paracelsus 10,000 is a prospective cohort study with the objective to investigate the health status of the population in and around the city of Salzburg. The focus lies on common non-communicable diseases, mainly cardiovascular and cerebrovascular diseases, and their risk factors.
Methods
Inhabitants of the city of Salzburg and the surrounding were randomly selected and underwent a preventive medical checkup. The program included medical examinations, as well as inventories on mental disorders and lifestyle including nutrition and physical activity. From all study participants biological samples were stored in a biobank at -80°C enabling future investigations of biomarkers and utilization of the whole spectrum of multi-omics.
Results
Between the years 2013 and 2020, 10,062 participants, 5,187 women and 4,875 men aged between 23 and 77 years, were investigated in the study. Participants of the age group 50-59 years, making up 42.3% of the cohort were in the focus of the study. In this group, 2620 participants underwent an extended investigation program.
Conclusion
The Paracelsus 10,000 study has attained a unique position within the framework of Austrian epidemiological research with the potential to gain new insight into the role of interactions between genetic predisposition and lifestyle factors for disease development in the Salzburg population. This report describes rationale, objectives and design of the study and provides insight into the main characteristics of the study cohort.
Fast And Robust Imputation For Mirna Expression Data Using Constrained Least Squares
Authors: Webber James , Elias Kevin 
Published: March 2022

Abstract
High dimensional transcriptome profiling, whether through next generation sequencing techniques or high-throughput arrays, may result in scattered variables with missing data. Data imputation is a common strategy to maximize the inclusion of samples by using statistical techniques to fill in missing values. However, many data imputation methods are cumbersome and risk introduction of systematic bias. Here we present a new data imputation method using constrained least squares and algorithms from the inverse problems literature and present applications for this technique in miRNA expression analysis. The proposed technique is shown to offer an imputation orders of magnitude faster, with greater than or equal accuracy when compared to similar methods from the literature.
Diabetes Mellitus and Bell’s Palsy
Authors: Papanas Nikolaos , Stamatiou Iliana , Papachristou Stella 
Published: March 2022

Abstract:
The aim of the present brief review was to discuss Bell’s palsy (BP) in diabetes
mellitus (DM). The risk of BP is increased in DM. DM subjects with BP are more prone to
severe facial nerve degeneration. Further characteristics of BP in DM include a) infrequent
taste impairment; b) more frequent and more marked facial nerve subclinical electrophysiological
impairment; c) more frequent Blink reflex impairment; d) potentially concurrent distal
symmetrical sensorimotor polyneuropathy; e) more frequent alternating BP with recurrent episodes
affecting different sides of the face. Diagnosis of BP rests on clinical examination,
along with facial nerve electromyographic and electroneurographic evaluation. Management
of BP in DM includes physical therapy, corticosteroids, and antiviral agents. Finally, acupuncture,
low-level laser therapy, lipoprostaglandin E1, and stellate ganglion block are new
modalities with initially promising results.
Multifunctional Role of Phytochemicals Derived from Boerhaavia diffusa
L. in Human Health, Ailments, and Therapy
Authors: Das Sarita , Sahoo Biswa Mohan , Bhattamisra Subrat Kumar 
Published: March 2022

Background:
The whole plant of Boerhaavia diffusa L. (BD) has wide ethnomedicinal
and ethnopharmacological applications. It is a versatile medicinal herb with tremendous antioxidant
potential, used commonly in Asian and African countries for a variety of Ayurvedic formulations
as a “Rasayan” or Rejuvenator.

Objective:
This paper is aimed at providing an extensive study of the phytochemistry and pharmacology
of BD to support its ethnopharmacological uses and the effectiveness of different active
constituents present in BD. We believe that this paper will provide an insight into various trends
and advances for future studies on BD.

Methods:
All relevant information was collected from worldwide accepted search engines and
databases, i.e., Google, Pub Med, Elsevier, Science Direct and Web of Science, etc.

Results:
Based on the study conducted for this paper, it was found that BD is a rich source of
several phytochemicals that are extracted from its roots and aerial parts. Among them, secondary
metabolites such as alkaloids, phenolics, flavonoids, isoflavonoids, rotenoids, glycosides, steroids,
and lignans are the most important ones. The crude extract and the isolated phytochemicals are
reported to have impressive bioactivities such as immunomodulatory, hepatoprotective, renoprotective,
cardioprotective, antidiabetic, anti-inflammatory, antifertility, antioxidant, anticancer, and
antimicrobial properties.

Conclusion:
The immense therapeutic potential of BD has been explored in many experiments,
which validates its traditional uses. However, reports from clinical trials and the specific interaction
of isolated phytoconstituents with microbial toxins or molecular markers of pathogenesis are
meager. Therefore, further studies can be undertaken to elucidate the molecular cross-talk between
the major therapeutic components with pathological biomolecules.