bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EFFECTS OF EXTRACTS OF ATRACTYLODES MACROCEPHALA KOIDZ COMBINED WITH TRANSCUTANEOUS ELECTRICALACUPOINT STIMULATION IN TREATING THE OVARIECTOMIZED FEMALE RATS
Authors: Weng Qing , Cao Zhu-Feng , Yu Yan-Wen , Lv Xiang-Lin , Qu Fan , Zhou Jue 
Published: May 2022

Background: The present study was to explore the effects of the extracts of Atractylodes macrocephala Koidz (EAMK) combined
with transcutaneous electrical acupoint stimulation (TEAS) on the ovariectomized female rats.
Materials and Methods: Forty female Sprague-Dawley rats were randomly divided into four groups: sham-operation, model, livial
and EAMK+TEAS groups (n=10 in each group). After the individual treatments for 8 weeks ended, the serum levels of estradiol
(E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), osteocalcin and interleukin-6 (IL-6) were measured with
commercial enzyme-linked immunosorbent assay.
Results: We found that in the sham-operation group, the serum E2 and osteocalcin levels were significantly higher, and the serum
levels of FSH, LH and IL-6 were markedly lower than those of other groups (P0.05), however, the serum FSH and IL-6 levels of
EAMK+TEAS group were significantly lower than those of the livial group (P
INFLUENCE OF SULFUR FUMIGATION ON VOLATILE OIL CONSTITUENTS OF CODONOPSIS RADIX (DANGSHEN) BY GC-MS METHOD
Authors: Ma Xiao-qing , Li Su-mei , Chan Chi Leung , Su Tao , Cheng Brian Chi-Yan , Li Wei-dong , Fun Fong David Wang , Yu Zhi-ling 
Published: May 2022

Background: Sulfur fumigation is a kind of the processing methods of Chinese medicinal herbs. It can kill contaminated/parasitical microbes and insects on the herbs and to bleach the herbs. Codonopsis Radix, dried roots of Codonopsis pilosula (Dangshen in Chinese), is one of the herbs commonly processed by sulfur fumigation. This study reports the influence of sulfur fumigation on the chemical constituents of volatile oils of Dangshen.
Methods: The volatile oils of air-dried or fumigated Dangshen samples were extracted by water-steam distillation and separated by GC capillary column chromatography. The components in individual volatile oil samples were identified and quantitatively determined by GC-MS.
Results: The results showed that forty-five compounds were separated and identified from the volatile oils of Dangshen samples. The contents of 2-octyn-1-ol, phenylethyl alcohol, paeonol and cedrenol in sulfur fumigated Dangshen were much lower than in air-dried Dangshen. On the contrary, the contents of α-lonone, sativene, thujopsene, tetradecanoic acid and methyl cis-9,10-epoxystearate were increased by sulfur fumigation.
Conclusions: Sulfur fumigation caused significant changes on the volatile oil constituents of Dangshen samples. Further explorations are necessary to investigate how these chemical changes occurred and whether these changes would affect the efficacy and safety of Dangshen.
Key words: Sulfur fumigation; volatile oil; Dangshen; Codonopsis pilosula; GC-MS
ASSOCIATION OF MTHFR A1298C POLYMORPHISMWITH BREAST CANCER AND/OR OVARIAN CANCER RISK: AN UPDATED META-ANALYSIS
Authors: Liu Wei , Li Yi , Li Rui , Han Xiao , Ma Ying , Liu Bin , Kong Xiangzhen 
Published: May 2022

Background: Recent years have witnessed the discovery of similar gene variations between breast cancer and ovarian cancer, inherited breast
and ovarian cancer in particular. A large number of case-control studies have been conducted to explore the association of
Methylenetetrahydrofolate Reductase (MTHFR) A1298C polymorphism with breast cancer and/or ovarian cancer risk. However, the results are
still inconsistent and inconclusive. Consequently, we performed a meta-analysis to evaluate the association between MTHFR A1298C
polymorphism and breast, ovarian cancer risk.
Materials and Methods: A comprehensive retrieval was conducted in the electronic database of PubMed, Web of Science and Chinese National
Knowledge Infrastructure (CNKI) until June 2015 to identify eligible studies. A total of 35 studies which examined the association of MTHFR
A1298C polymorphism with breast cancer and/or ovarian cancer were identified. The pooled odds ratios (ORs) with 95 % confidence intervals
(CIs) were used to assess the effect of gene polymorphism. And allele model, homozygous model, co-dominant model, dominant model,
recessive model were applied.
Result: In the overall analysis, significantly increased breast cancer and/or ovarian cancer risk was found (for allele model A VS C OR = 1.05,
CI: 1.02-1.08, P = 4×10-3; for homozygous model AA VS CC OR = 1.11, CI: 1.03-1.19, P = 5×10-3; for recessive model (AC +AA) VS CC: OR
= 1.10, CI: 1.03-1.18, P = 7×10-3).
Conclusion: In the subgroup analysis, significantly increased breast cancer risk was identified among Caucasians. MTHFR A1298C
polymorphism might contribute to an increased risk of breast cancer and/or ovarian cancer susceptibility. In addition, MTHFR A1298C
polymorphism had a significant association with breast cancer in Caucasians.
ANTI-NOCICEPTIVE EFFECT OF AGRIMONIA EUPATORIA EXTRACT ON A CISPLATIN-INDUCED NEUROPATHIC MODEL
Authors: Lee Keyong Ho , Rhee Ki-Hyeong 
Published: May 2022

Background: Natural products including Agrimonia eupatoria are considered an incomparable source of molecular diversity that has led to the medicines, especially for pain treatment. To investigate the antinociception of Agrimonia eupatoria, we examined its activity in a rat model of cisplatin neuropathy.
Materials and Methods: Male Sprague-Dawley rats received intraperitoneal (i.p.) cisplatin twice a week at a dose of 2 mg/kg (cumulative dose, 20 mg/kg) for 4 weeks. Before each injection, 2 ml of sterile saline solution was given subcutaneously to prevent renal damage via hyperhydration. The mice were treated with gabapetin as a positive control drug with a 100mg/kg intraperitoneal injection. A. eupatoria extract of 200mg/kg was solved in saline and then treated by oral administration.
Results: The mice treated with A. eupatoria showed lower withdrawal duration in the pin-prick and plantar tests, and a higher withdrawal threshold in the paw-withdrawal threshold test as compared to control animals in a cisplatin-induced neuropathic model. In the case of cold-allodynia, A. eupatoria treatment increased paw-withdrawal duration in a chemical test. A. eupatoria showed a more outstanding effect than gabapentin in all used tests for preventing cisplatin-induced nerve injury for 4 weeks.
Conclusions: Our results suggest that A. eupatoria extract showed an antinociceptive effect in the pin-prick test, plantar test, and paw-withdrawal threshold test using a cisplatin-induced neuropathic rat model.
Ajaran Kepemimpinan Jawa dalam Serat Nitisruti dan Relevansinya dengan Pendidikan
Authors: Fahmi Izzuddin Rijal 
Published: May 2022

AbstractOne result of culture is literature. As a cultural heritage, old literature can also reveal information about past cultural outcomes through classical texts that can be read in relics in the form of writing or texts. In Java, manuscripts that are still in the form of handscript text or that have been in the form of copies are referred to as serat. The contents of the Javanese script (serat) mostly contain teachings (piwulang), so it is called a didactic literature. The teachings contained in the Javanese text range from Islamic mysticism esoterism (Sufism) to leadership ethics. One of the Javanese texts containing the teachings of leadership is Serat Nitisruti. This research’s goals are: (1) to identify the Serat Nitisruti, and (2) to analyze the Javanese leadership didactic in Serat Nitisruti and its relevance to Islamic education. Using the philological method consisting of: (1) manuscript inventory, (2) manuscript description, (3) text edits, (4) text translation, and (5) content analysis. AbstrakSalah satu hasil dari budaya adalah karya sastra. Sebagai warisan kebudayaan, sastra lama juga dapat mengungkapkan informasi tentang hasil budaya pada masa lampau melalui teks klasik yang dapat dibaca dalam peninggalan-peninggalan yang berupa tulisan atau naskah. Di Jawa, naskah yang masih berupa teks tulisan tangan atau yang sudah dalam bentuk salinan disebut sebagai serat. Isi dari naskah Jawa (serat) itu sebagian besar memuat ajaran (piwulang), sehingga disebut naskah didaktik (didactic literature). Ajaran-ajaran yang dimuat dalam naskah Jawa terentang mulai dari esoterisme mistik Islam (tasawuf) hingga etika-moralitas kepemimpinan. Salah satu naskah Jawa yang memuat ajaran kepemimpinan adalah Serat Nitisruti. Penelitian ini bertujuan untuk: (1) mengidentifikasi naskah Serat Nitisruti, dan (2) menganalisis ajaran kepemimpinan Jawa dalam Serat Nitisruti dan relevansinya dengan pendidikan Islam. Menggunakan metode filologi yang terdiri dari: (1) inventarisasi naskah, (2) deskripsi naskah, (3) suntingan teks, (4) terjemahan teks, dan (5) analisis isi.
Perubahan Kurikulum di Madrasah Aliyah Negeri 2 Ponorogo Sebagai Upaya Peningkatan Kualitas Lembaga Pendidikan Islam
Authors: Ahmadi Ahmadi , Chairiyah Yayah , Baqi Safiruddin Al 
Published: May 2022

AbstractQuality education today is an essential necessity in human life. The purposes of this research are to describe how the dynamics of curriculum goes on. It used a qualitative descriptive approach. The instruments of collecting data are observation, interview, and document. The data must be analyzed by the following cycles: reduction, display and verification. It showed that; curriculum religious teacher training is different with the curriculum of Islamic High School. The implementation of the curriculum has to improve some knowledge and policy continuously, especially, to master the curriculum component system supported to the vision. Those are; setting up teachers and education staffs with the standards of educational, structuring teachers to teach according to their field of study, and involving them in any kinds of training and curriculum development policy. It faces several obstacles lacking of curriculum development experiences and theories, educational personnel should contribute more than before in curriculum development.Key words; Curriculum, education system, Islamic education, madrasah. AbstrakPendidikan yang berkualitas merupakan keperluan esensi yang amat penting dalam kehidupan manusia masa sekarang. Penelitian ini bertujuan untuk mengkonstruk bagaimana dinamika kurikulum berlangsung. Penelitian menggunakan pendekatan studi kasus. Gambaran fakta data diperoleh melalui teknik pengamatan, wawancara, dan dokumen. Data dianalisa dengan siklus; reduksi, pemaparan dan simpulan. Hasil riset menunjukan; kurikulum Pendidikan Guru Agama berbeda dengan Madrasah Aliyah, implementasi kurikulum madrasah meningkatkan pengetahuan dan komponen kurikulum yang mendukung terhadap visi. Proses tahapan tersebut; menyiapkan guru dan staff perkantoran yang sesuai dengan kualifikasi pendidikan, guru mengajar sesuai dengan bidangnya, mengikutsertakan mereka dalam kebijakan program pelatihan dan pengembangan kurikulum. Implementasi menghadapi beberapa kendala; kurang pengalaman dalam pengembangan dan pengasaan teori, pelaksana kurikulum seharusnya dapat berkonstribusi lebih dalam pengembangannya.
Technology Focus: Natural Gas Processing and Handling (April 2022)
Authors: Wilson Adam 
Published: May 2022

Natural gas has two faces. On one side, it is an important part of the energy-transformation toolkit. On the other side, it is a potent greenhouse gas. Technology can bring the two sides together.
The three papers selected for this Tech Focus feature describe technologies that can make natural gas safer to move and store.
The first paper, OTC 30655, describes an effort to eliminate flaring during offloading from a floating liquefied natural gas facility (FLNG) and an LNG carrier. Managing the balance of fuel gas and boiled-off gas between the FLNG and the carrier is vital to maintaining equilibrium and eliminating flaring. The paper looks at carriers with spherical tanks and presents a process study to identify potential causes of flaring during offtake and corrections that could eliminate it without capital modifications.
The second paper, OTC 30871, considers the benefits of barges over ship-type LNG carriers. Ship-type LNG carriers are designed to operate offshore over fields, which does not necessarily provide optimal opportunity for monetization. The paper argues that near-shore barges holding liquefaction facilities linked to the rest of the system elsewhere could be a more-viable gas-monetization concept.
The third paper, SPE 204787, describes a characterization and monitoring approach for underground gas storage. The approach involves close integration of subsurface understanding with the optimization of surface facilities. It also addresses sustainable operations through an asset-integrity-management plan.
To learn more about the advancement of technology in the natural gas space, check out the suggested additional reading and visit the OnePetro online library.
Recommended additional reading at OnePetro: www.onepetro.org.
IPTC 19783 - Hybrid System—An Emerging Solution to Sour Gas Treatment by Siddharth Parekh, Schlumberger
SPE 202984 - Sour Gas Has a Sweeter Future—Bulk H2S Removal Using Polymeric Cellulose Triacetate-Based Membranes by Pinkesh Sanghani, Schlumberger, et al.
SPE 208134 - Inventory Verification in Underground Gas Storage Rebuilt From Depleted Gas Reservoir: A Case Study From China by Lina Song, PetroChina, et al.
SPE 207956 - Unconventional Waste and Flare Gas Recovery System in New Circular Economy by Mohamed Ahmed Soliman, Saudi Aramco, et al.
Study Summarizes 20 Years of Horizontal Multistage Completions
Authors: Carpenter Chris 
Published: May 2022

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 207698, “Twenty Years of Horizontal Multistage Completions: A Summary of Industry Evolution in Unconventional and Conventional Plays,” by Alberto Casero, SPE, BP. The paper has not been peer reviewed.
The innovative idea behind the shale gas revolution was the combination of horizontal well drilling and hydraulic fracturing, which allowed for an increase in the surface area available for hydrocarbon flow and overcame the slow, shallow hydrocarbon release from the source rock. To achieve the high number of hydraulic fractures needed for economical production, different execution techniques evolved in what became known as horizontal multistage fracturing (HMSF) completions. The complete paper covers the most-common types of HMSF completion systems and includes a section about the use of these completions in conventional plays. This synopsis focuses on HMSF use in unconventionals.

Well Architecture as a Function of Location and Reservoir Properties
As hydraulic fracturing and horizontal wells became popular, many preconceptions associated with hydraulic fracturing had to be reimagined. The concept of stimulated reservoir volume (SRV) was introduced; contacting as much rock as possible was the new priority of hydraulic fracturing, while more-conventional fracturing concepts such as fracture conductivity and planar fractures became secondary or irrelevant.
Fracture-production interference and fracture complexity became an aim rather than representing a risk. Very high fracture count and reduced well spacing became a necessity, and, inevitably, a mass-production approach had to be applied rather than an individual fit-for-purpose design for each well or fracture. These changes brought a substantial shift in primary well-construction costs, with completion costs in many cases surpassing the drilling cost by a factor of 40–50%.
Multistage fracturing with complex and developed fracture networks or SRV, which is at the basis of unconventional developments, requires a robust infrastructure and resource availability to allow easily moving large amounts of proppant (typically natural sands) and water. This can be challenging for remote locations.
When permeability decreases, cased and perforated completions with hydraulic fracturing or acid stimulations become the norm. When permeability decreases even further, multistage fractures and horizontal wells are applied; finally, in ultratight gas and shale gas, horizontal multistage fracturing represents the only option.
Iterative Ensemble Kalman Smoother Applied to History-Matching Coalbed Methane Wells
Authors: Carpenter Chris 
Published: May 2022

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper URTEC 208291, “Introducing Iterative Ensemble Kalman Smoother to History-Matching Horizontal Coalbed Methane Wells,” by Rubakumar Sankararaj, SPE, and Sylvain Ducroux, SPE, Resoptima, and Dan Kuznetsov, SPE, Arrow Energy, et al. The paper has not been peer reviewed.
This study presents the iterative ensemble Kalman smoother applied to a low-permeability coalbed methane (CBM) field in Australia. All wells in the studied reservoir are completed with an artificial lift system and permanent downhole gauges. A forecast study was conducted to validate the history-matched ensemble. The results showed a good match of 12 months of the new production data not used in history matching, which highlights the robust prediction capabilities of the approach.

Geology of the Study Area
Because of its strategic geologic and geographic situation in Queensland State, the Bowen-Surat area constitutes one of the more economically significant sedimentary provinces of the Australian mainland and one of the world’s major coal and coal-seam-gas-producing regions.
This study considers the Q seam from the Late Permian. Although its thickness varies in the basin because of merging and splitting, it is continuous locally, with an approximate thickness of 5–6 m.
A Novel Signature to Predict Thyroid Cancer Prognosis and Immune Landscape Using Immune-Related LncRNA Pairs
Authors: SONG BO , Teng Weiping , Tian Lijun , Zhang Fan , Lin Zheyu , Gong Boshen , Liu Tingting 
Published: May 2022

Abstract
Background
Thyroid cancer (TC) is the most common endocrine malignancy worldwide. The incidence of TC is high and increasing worldwide due to continuous improvements in diagnostic technology. Therefore, determining accurate prognostic predictions to stratify TC patients is important.
Results
Raw data were downloaded from the TCGA database, and pairwise comparisons were applied to identify differentially expressed immune-related lncRNA (DEirlncRNA) pairs. We identified 14 DEirlncRNA pairs through univariate Cox regression analysis and a modified Lasso algorithm Lasso regression as the novel predictive signature. We further used qRT-PCR analysis to validate the expression levels of irlncRNA in the model. The results were consistent with the bioinformatics results obtained by the TCGA dataset. Next, TC patients were assigned to high- and low-risk groups based on the optimal cutoff score of the model for the 1-year ROC curve. The high-risk group had a significantly poorer prognosis than the low-risk group. Cox regression analysis revealed that this immune-related signature can predict prognosis independently and reliably for TC. With the CIBERSORT algorithm, we found an association between the signature and immune cell infiltration. Additionally, several immune checkpoint inhibitor (ICI)-related molecules, such as PD-1 and PD-L1, showed a negative correlation with the high-risk group. We further found that some commonly used small-molecule inhibitors, such as sunitinib, were related to this new signature.
Conclusions
We constructed a prognostic immune-related lncRNA signature that can predict TC patient survival without considering the technical bias of different platforms, and this signature also sheds light on TC’s overall prognosis and novel clinical treatments, such as ICB therapy and small molecular inhibitors.
Establishment of a finite element model of supination-external rotation ankle joint injury and analysis of mechanical changes in the posterior malleolar surface
Authors: Zhang Xin , Xie Pinliang , Shao Weirong , Xu Ming , Xu Xiaoping , Yin Yong , Fei Lan 
Published: May 2022

Abstract
Background By establishing a three-dimensional finite element model of supination and external rotation ankle injury, the stress characteristics of the posterior ankle joint surface can be obtained, and complete analysis of the corresponding stress on the lateral ankle can be conducted.Methods Thin-layer computed tomography (CT) images of normal ankle joints in the supination and external rotation nonweight-bearing states were selected, a three-dimensional data model of each ankle joint, including the ligament, was established, and whether different stages of injury coexisted with lateral ankle fracture was analysed by the finite element method. A load was applied to examine different ankle joint stress values and pressure distributions on the surface of the posterior ankle joint.Results When a load was applied, the maximum stress was located at the point of attachment of the anterior tibiofibular ligament to the tibia. When the anterior tibiofibular ligament was removed and the lateral malleolus was intact, the maximum stress (271.2 MPa) was located at the attachment point of the posterior tibiofibular ligament to the tibia, and the maximum pressure of the posterior ankle joint surface was 2.626 MPa. When a lateral malleolar fracture was present and the same load was applied, the maximum stress (82 MPa) was located on the fibular fracture surface, and the maximum pressure of the posterior ankle joint surface was 7.787 MPa. The posterior tibiofibular ligament was then removed completely from the lateral malleolus, upon which the maximum stress (132.7 MPa) was located at the point of attachment of the posterior tibiofibular ligament to the fibula and the maximum pressure of the posterior ankle joint surface was 4.505 MPa. When a lateral malleolar fracture was present, the maximum stress (82.72 MPa) was located on the fibular fracture surface, and the maximum pressure of the posterior ankle joint surface was 8.022 MPa.Conclusion This study shows that reconstruction of the lateral malleolus in supination-external rotation ankle injury significantly affects the stress distribution at the posterior malleolar joint surface. When reconstruction of the lateral malleolus is complete, the pressure distribution of the posterior malleolar joint surface can be significantly reduced. The disappearance of pressure concentration helps reduce the stresses associated with posterior ankle fracture. At this time, the rotational stress imposed by posterior ankle fracture is significantly higher than the vertical stress; the former should be the focus of clinician attention to ensure optimal healing.
The role of preserved bowel and mesentery fixation in apple-peel intestinal atresia
Authors: han jinbao , Hao Zenghui , Wang Long , Yao Ting , Fan Wei , Zhao Zheng , huang liuming , xu zhilin 
Published: May 2022

Abstract
Objective
This study explored the feasibility of mesoplasty with end-to-side anastomosis in the treatment of different apple-peel mesenteric defects with high jejunal atresia.
Methods
A retrospective analysis was performed on 42 premature infants admitted to the hospital between 2014 and 2021. Prenatal ultrasound scans revealed bowel dilatation. The patients experienced vomiting after birth and produced white or no meconium. Plain radiography showed double or triple bubble signs and the patients underwent emergency laparotomies. High jejunal atresia with different apple-peel atresia appearance was discovered intraoperatively, involving mobilization of the ileocecal region. Patients received end-to-side anastomosis between the enlarged blind pouch and atresic bowel, as well as mesoplasty. A jejunal feeding tube was placed trans-nasally. Patients were discharged after achieving full enteral feeding.
Results
Three patients died and 39 survived. The discharged patients were followed up for 12 months, and none showed post-operative complications such as intestinal obstruction, malnutrition, or chronic diarrhea. All surviving patients reached the expected height and weight for children of the same age.
Conclusion
For cases of high jejunal atresia with apple-peel intestinal atresia, mesoplasty is a good option to avoid postoperative volvulus.