bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract P034: Tumor-targeted interleukin-12 and Entinostat combination therapy improves cancer survival by reprogramming the tumor immune cell landscape
Authors: Hicks Kristin C. , Chariou Paul L. , Ozawa Yohei , Minnar Christine M. , Knudson Karin M. , Meyer Thomas J. , Bian Jing , Cam Margaret , Schlom Jeffrey , Gameiro Sofia R. 
Published: January 2022

Abstract
Clinical benefit remains elusive for most patients with poorly inflamed carcinomas treated with immune checkpoint blockade. Converting the tumor microenvironment into a functionally inflamed immune hub would increase clinical benefit. By using comprehensive single-cell transcriptome, proteome, and immune cell analysis, we demonstrate here that Entinostat, a class I histone deacetylase inhibitor, facilitates accumulation of the necrosis-targeted recombinant murine immune-cytokine, NHS-rmIL12, in experimental mouse colon carcinomas and poorly immunogenic breast tumor in which the therapy was curative. Combination therapy reprogrammed the tumor innate and adaptive immune milieu to an inflamed landscape, where the concerted action of highly functional CD8+ T cells and activated neutrophils drove a dramatic macrophage M1-like polarization leading to complete tumor eradication in 41.7%-100% of cases. Biomarker signature of favourable overall survival in multiple human tumor types showed close resemblance to the immune pattern generated by Entinostat/NHS-rmIL12 combination therapy. Collectively, these findings provide a rationale for combining NHS-IL12 with Entinostat in the clinical setting.
Citation Format: Kristin C. Hicks, Paul L. Chariou, Yohei Ozawa, Christine M. Minnar, Karin M. Knudson, Thomas J. Meyer, Jing Bian, Margaret Cam, Jeffrey Schlom, Sofia R. Gameiro. Tumor-targeted interleukin-12 and Entinostat combination therapy improves cancer survival by reprogramming the tumor immune cell landscape [abstract]. In: Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy; 2021 Oct 5-6. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(1 Suppl):Abstract nr P034.
Abstract P047: Inactivation of IFN signaling drive immunosuppressive MDSC function and can be therapeutically targeted
Authors: Sanseviero Emilio , Alicea-Torres Kevin , Nefedova Yulia , Fuchs Serge Y. , Gabrilovich Dmitry I. 
Published: January 2022

Abstract
Myeloid-derived suppressor cells (MDSC) are pathologically activated neutrophils and monocytes with potent immune suppressive activity that promote tumor progression and impair the efficacy of anti-tumor therapeutics. Herein we show that type I interferons (IFN1) receptor dampen immune suppressive activity of MDSC. Downregulation of the IFNAR1 is found in MDSC from cancer patients and mouse tumor models. Downregulation of IFNAR1 depends on the activation of the p38 protein kinase and is required for activation of the immune suppressive phenotype moreover genetic stabilization of IFNAR1 in tumor bearing mice reduces suppressive activity of MDSC and promote antitumor effect. Stabilizing IFNAR1 using inhibitor of p38 combined with the interferon induction therapy elicits a robust anti-tumor effect that is completely dependent on IFNAR1 expression on MDSC. Thus, inhibition of MDSC immune suppressive function can be exploited therapeutically.
Citation Format: Emilio Sanseviero, Kevin Alicea-Torres, Yulia Nefedova, Serge Y. Fuchs, Dmitry I. Gabrilovich. Inactivation of IFN signaling drive immunosuppressive MDSC function and can be therapeutically targeted [abstract]. In: Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy; 2021 Oct 5-6. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(1 Suppl):Abstract nr P047.
Abstract P063: Tumor cell-derived lactic acid inhibit anti-tumor immunity in the immune checkpoint blockade resistant tumor
Authors: Oh Wonkyung , Kim Alyssa Min Jung , Sun Ruoxuan , Lim Seung-Oe 
Published: January 2022

Abstract
Immune checkpoint blockade therapy targeting the PD-1/PD-L1 axis, one of the most promising cancer immunotherapies, has shown remarkable clinical impact in multiple cancer types. Despite the recent success of PD-1/PD-L1 blockade therapy, acquired resistance, emerging as late relapses or recurrences, has been reported in the long-term follow-up of clinical trials. However, the resistance mechanisms of PD-1/PD-L1 blockade therapy are still unclear. Here we found that tumor cell-derived lactate rendered the immunosuppressive tumor microenvironment in the PD-1/PD-L1 blockade resistant tumors. Interestingly, increased lactate in the PD-1/PD-L1 blockade resistant tumors enhanced PD-1/PD-L1 interaction. Furthermore, combining a PD-L1-antibody-drug conjugate (ADC) with AZD3965, a MCT inhibitor eradicated the resistant tumor cells synergistically in 4T1 syngeneic murine models. Together, our results suggest a new combination treatment strategy to improve the therapeutic efficacy of immune checkpoint blockade therapies.
Citation Format: Wonkyung Oh, Alyssa Min Jung Kim, Ruoxuan Sun, Seung-Oe Lim. Tumor cell-derived lactic acid inhibit anti-tumor immunity in the immune checkpoint blockade resistant tumor [abstract]. In: Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy; 2021 Oct 5-6. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(1 Suppl):Abstract nr P063.
Abstract PR02: The co-expression of VISTA and TIGIT on cytotoxic T cells defines subpopulation with altered immunometabolism
Authors: Gilmour Cassandra , Yoo Seong-Keun (Steve) , Chan Timothy , Wang Lily 
Published: January 2022

Abstract
Cancer immunotherapies, specifically checkpoint blockade therapies, are extremely successful at treating subpopulations of specific cancers long term. The idea is to disrupt the negative regulation of T cells and restore cytotoxic abilities allowing killing of the cancer cells and formation of memory T cells. This provides immunity that has the potential to last a lifetime against recurring cancer. One major limitation to checkpoint blockade is that it is has limited response rate, one theory as to why this is the case, is that there are multiple non-redundant pathways of regulation of T cell activation. In response to the heterogeneous and suppressive tumor microenvironment, the T cell may present many immune checkpoint proteins simultaneously. Thus, it is important to study the immune checkpoint proteins in context of one another with the goal of developing combinatorial therapies. Here we present the co-expression of two immune checkpoint proteins and how their co-expression results in altered metabolism in cytotoxic T cells. V-domain Immunoglobulin Suppressor of T-cell Activation (VISTA) is a protein with many roles that are still largely undefined across a variety of immune cells in which it is expressed. T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) is a bi-directional receptor that has been reported to have a suppressive intrinsic T cell role when probed with agonistic antibody, the mechanism is yet to be defined. Our data suggest that VISTA and TIGIT are co-expressed in varying amounts across a variety of murine and human cancers and that this co-expression may contribute to an altered metabolic phenotype. Our results give insight to the contribution of multiple checkpoint proteins to the state of the cytotoxic T cell and declare the importance of studying these proteins in context of one another. This data reaffirm the need to study non-redundant pathways of T cell suppression with the goal of developing inhibitors that are more broadly applicable to restore anti-tumor immunity and increase patient survival.
Citation Format: Cassandra Gilmour, Seong-Keun (Steve) Yoo, Timothy Chan, Lily Wang. The co-expression of VISTA and TIGIT on cytotoxic T cells defines subpopulation with altered immunometabolism [abstract]. In: Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy; 2021 Oct 5-6. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(1 Suppl):Abstract nr PR02.
Auto tuning of frequency on wireless power transfer for an electric vehicle
Authors: Yamaguchi Kazuya , Iida Kenichi 
Published: January 2022

<p>In these days, electric vehicles are enthusiastically researched as a countermeasure to air pollution, although these do not have practicality compared to gasoline-powered vehicles. The aim of this study is to transport energy wirelessly and efficiently to an electric vehicle. To accomplish this, we focused on frequency of an alternating current (AC) power supply, and suggested a method which determined the value of it constantly. In particular, a wireless power transfer circuit and a lithium-ion battery in an electric vehicle were expressed with an equivalent circuit, and efficiency of energy transfer was calculated. Furthermore, the optimal frequency which maximizes efficiency was found, and the behavior of voltage was demonstrated on a secondary circuit. Finally, we could obtain the larger electromotive force at the secondary inductor than an input voltage.</p>
An efficient design of 45-nm CMOS low-noise charge sensitive amplifier for wireless receivers
Authors: Almalkawi Islam T. , Al-Bqerat Ashraf H. , Itradat Awni , Al-Karaki Jamal N. 
Published: January 2022

<p>Amplifiers are widely used in signal receiving circuits, such as antennas, medical imaging, wireless devices and many other applications. However, one of the most challenging problems when building an amplifier circuit is the noise, since it affects the quality of the intended received signal in most wireless applications. Therefore, a preamplifier is usually placed close to the main sensor to reduce the effects of interferences and to amplify the received signal without degrading the signal-to-noise ratio. Although different designs have been optimized and tested in the literature, all of them are using larger than 100 nm technologies which have led to a modest performance in terms of equivalent noise charge (ENC), gain, power consumption, and response time. In contrast, we consider in this paper a new amplifier design technology trend and move towards sub 100 nm to enhance its performance. In this work, we use a pre-well-known design of a preamplifier circuit and rebuild it using 45 nm CMOS technology, which is made for the first time in such circuits. Performance evaluation shows that our proposed scaling technology, compared with other scaling technology, extremely reduces ENC of the circuit by more than 95%. The noise spectral density and time resolution are also reduced by 25% and 95% respectively. In addition, power consumption is decreased due to the reduced channel length by 90%. As a result, all of those enhancements make our proposed circuit more suitable for medical and wireless devices.</p>
Juicios de la gente corriente acerca del gobierno de Allende: resultados de una encuesta panel aplicada en 1972 y 1973
Authors: Mac-Clure Oscar , Lamadrid Silvia , Conejeros José Daniel 
Published: January 2022

Se estudian los juicios de los individuos acerca del período del gobierno del Presidente Allende en Chile, particularmente la crisis que se agudizó en los años 1972 y 1973, que precedió al golpe militar de septiembre de 1973 y la instauración de una dictadura. Se enfatiza en la perspectiva de las personas corrientes, en base a inéditos datos de una encuesta panel aplicada durante el período por un equipo de investigadores encabezados por Eduardo Hamuy, uno de los fundadores de la sociología en Chile. Se sigue a las mismas personas entre el momento previo a la agudización dela crisis y luego cuando ésta ya había madurado, distinguiendo a los encuestados según su posición con respecto al apoyo al Presidente. La evolución de la opinión de las personas encuestadas amplía el conocimiento sobre el período a nivel microsocial en la sociedad chilena. A partir de los individuos encuestados, se analizan aspectos claves relacionados con género, clase social, identidad política y opinión sobre los principales problemas del país.
Observing observers in social systems theory.: an interview with Hans-Georg Moeller
Authors: Minhoto Laurindo Dias , Amato Lucas Fucci , Barros Marco Antonio Loschiavo Leme de 
Published: January 2022

On November 4th, 2019, Hans-Georg Moeller delivered a presentation on systems theory at the Law School of the University of São Paulo and was interviewed about Niklas Luhmann’s theory of society, with emphasis on issues such as law, politics, and the history of philosophy. Professor Moeller is the author of important books such as Luhmann explained: From souls to systems (Moeller, 2006) and The radical Luhmann (Moeller, 2011), the latter also translated to Japanese and Italian. He also works on Chinese philosophy and is currently Full Professor at the Department of Philosophy and Religious Studies in the Faculty of Arts and Humanities of the University of Macau, China. Throughout the interview, professor Moeller situated Luhmann in the philosophical tradition of German idealism and presented the shift to second-order observation as a crucial aspect of contemporary society, in religion and politics, science, economy and law. The interview was conducted partly in writing and partly in the form of a recorded and transcribed debate.
Split distribution, biogeography and morphological and genetic diversity of the Iberobathynellini Tribe in the family Parabathynellidae (Crustacea, Malacostraca, Bathynellacea)
Authors: Camacho Ana Isabel , Mas-Peinado Paloma , López-Estrada E. Karen , Dorda Beatriz A. , Rey Isabel 
Published: January 2022

Abstract
The “Iberobathynella group”, or Iberobathynellini tribe, is a complex of six genera consisting of 33 nominal species and several cryptic species with an amphiatlantic distribution (in Europe, North Africa and North America). A modern systematic revision of this group of subterranean crustaceans is presented here. A phylogenetic and biogeographic study using morphological and molecular data (mitocondrial coi and nuclear 18S) was carried out and allowed to a) re-evaluate the taxonomic status and validity of previously erected subtribes, genera and subgenera that show congruence in the data; b) assess whether the identified mitochondrial lineages represent cryptic species; c) provide a plausible phylogenetic hypothesis for the relationships within Iberobathynellini and with the other two genera of the family Parabathynellidae that inhabit North America and Europe (Montanabathynella and Parabathynella, respectively); d) propose a plausible temporal and historical framework (paleobiogeographic scenario) for the diversification and evolution of the Iberobathynellini tribe based on the current distribution of morphotypes and their estimated times of divergence. Our results show that in parabathynellids, molecular and morphological divergences are not always congruent. Subtribe and subgenus are invalid categories so they must be eliminated. Paraiberobathynella genus needs to be revisited. The molecular dating results support the early divergence of the Iberobathynellini Tribe (Upper Cretaceous, around 78 Mya) and the vicariance by plate tectonics as main factor to explain the amphi-Atlantic distribution shown by this ancient subterranean crustacean group. Since there are species morphologically very similar to I. magna and I. imuniensis, but genetically different, we can ensure the existence of at least three cryptic species. Texanobathynella is undoubtedly a valid genus distinct from Iberobathynella. Montanabathynella and Parabathynella are two well-differentiated genera closely related to the Iberobathynellini tribe.
Evaluation of GPROF V05 Precipitation Retrievals under Different Cloud Regimes
Authors: Tan Jackson , Cho Nayeong , Oreopoulos Lazaros , Kirstetter Pierre 
Published: January 2022

AbstractPrecipitation retrievals from passive microwave satellite observations form the basis of many widely used precipitation products, but the performance of the retrievals depends on numerous factors such as surface type and precipitation variability. Previous evaluation efforts have identified bias dependence on precipitation regime, which may reflect the influence on retrievals of recurring factors. In this study, the concept of a regime-based evaluation of precipitation from the Goddard Profiling (GPROF) algorithm is extended to cloud regimes. Specifically, GPROF V05 precipitation retrievals under four different cloud regimes are evaluated against ground radars over the United States. GPROF is generally able to accurately retrieve the precipitation associated with both organized convection and less organized storms, which collectively produce a substantial fraction of global precipitation. However, precipitation from stratocumulus systems is underestimated over land and overestimated over water. Similarly, precipitation associated with trade cumulus environments is underestimated over land, while biases over water depend on the sensor’s channel configuration. By extending the evaluation to more sensors and suppressed environments, these results complement insights previously obtained from precipitation regimes, thus demonstrating the potential of cloud regimes in categorizing the global atmosphere into discrete systems.
Naples Prognostic Score to Predict Postoperative Complications After Colectomy for Diverticulitis
Authors: Russell Benjamin , Zager Yaniv , Mullin Gillie , Cohen Matan , Dan Assaf , Nevler Avinoam , Gutman Mordechai , Horesh Nir 
Published: January 2022

Background The Naples Prognostic Score (NPS) has proven efficacy as a prognostic tool for postoperative outcomes in patients undergoing surgery for neoplastic diseases. However, the role of the NPS score in inflammatory surgical diseases has not yet been studied. We aimed to evaluate NPS predictive value in patients undergoing colectomy due to diverticulitis. Methods A single-center retrospective study including all patients who underwent colectomy for diverticulitis between July 2008 and March 2020 was established. Patients' demographics, clinical and surgical data were recorded and analyzed. Patients were scored on a scale of 0-4 and received one point for preoperation albumin <4 g/dL, cholesterol ≤180 mg/dL, Neutrophil to Lymphocyte Ratio >2.96, and Lymphocyte to Monocyte ≤4.44. Results Out of 3292 patients admitted because of diverticulitis during the study period, 159 patients (4.83%) underwent colectomy. Of those patients, fifty patients were eligible for NPS analysis. 35 patients (70%) were females with a mean age of 62.81 ± 14.51. Thirty-two (64%) patients underwent an elective operation. The postoperative complications rate was 36% (N = 18). The mortality rate was 6% (N = 3). ROC showed a strong association between the NPS and mortality (area = .88, P = .03) and wound infection (area = .78, P = .01). In patients who underwent urgent surgery, there was an association between NPS and re-operation ( P = .04). There was a correlation between NPS and Clavien-Dindo score (Spearman’s coefficient = .284, P = .045). Conclusions/Discussion The Naples prognostic score is an effective tool for predicting postoperative complications in patients undergoing colectomy for diverticulitis. It may assist the surgeon in deciding on extent of the operation for diverticulitis and in elective cases also on timing.
In-Hospital Costs Associated With an Expanded Endonasal Approach to Anterior Skull Base Tumors
Authors: Parasher Arjun K. , Lerner David K. , Glicksman Jordan T. , Lin Theodore , Miranda Stephen P. , Ebesutani Darren , Kohanski Michael , Lee John Y. K. , Storm Phillip B. , O’Malley Bert W. , Yosher Daniel , Palmer James N. , Grady Sean , Adappa Nithin D. 
Published: January 2022

Objective: To determine in-hospital costs associated with performing an EEA to anterior skull base pathology and to identify drivers of cost variability for patients undergoing endoscopic anterior skull base surgery. Methods: All endoscopic anterior skull base surgeries performed over a period from January 1st, 2015 to October 24th, 2017 were evaluated. The electronic medical record was reviewed for patient factors, tumor characteristics, and cost variables associated with each hospital stay and univariate analysis was performed using Stata software. Results: An EEA was associated with an average total in-hospital cost of $44 545. Compared to patients undergoing a transsphenoidal approach to pituitary tumor resection, EEA patients incurred higher in-hospital costs across all variables including a total cost increase of $15 921 (95% confidence interval $5720-26 122, P = .002). Univariate analysis of all endoscopic anterior skull base surgery patients showed a cost increase of $30 616 associated with post-operative cerebrospinal fluid (CSF) leak ($10 420-50 811, P = .004), $14 610 with post-operative diabetes insipidus (DI) ($4610-24 609, P = .004), and $11 522 with African-American patients relative to Caucasian patients ($3049-19 995, P = .008). Conclusions: Patients who undergo endoscopic EEA for resection of anterior skull base tumors typically incur greater in-hospital costs than patients undergoing a standard TSA. Post-operative complications such as CSF leak and DI, as well as ethnicity, are significant drivers of cost-variability.
Graduating Otolaryngology Residents’ Ideal Practice Expectations: A Longitudinal Analysis
Authors: Miller Robert H. , Gurgel Richard K. , McCrary Hilary C. 
Published: January 2022

ObjectivePrior literature has indicated that the number of trained otolaryngologists required to meet the need of our growing population may be insufficient. Therefore, identifying trends in the subspecialty composition of future otolaryngology practices will elucidate workforce needs.Study DesignOne‐page anonymous questionnaire.SettingThe survey was completed by examinees at the conclusion of their American Board of Otolaryngology–Head and Neck Surgery oral examination from 2011 to 2019.MethodsData included age, gender, fellowship, practice type, and ideal future practice components.ResultsA total of 2286 examinees were included: 58.1% were male and 57.2% completed a fellowship. Ideal practice specialties included general otolaryngology (19%), rhinology (15%), head and neck (13%), and pediatrics (11%). General and pediatric otolaryngology had a negative correlation over time (r = −0.81, P =. 01, and r = −0.75, P =. 03, respectively). An overall 45% of graduates reported 1 ideal practice area (r = 0.61, P =. 10), with a statistically significant decline in the number of ideal practice areas over time (r = −0.79, P =. 018). Men more commonly reported allergy, head and neck, otology, rhinology, and sleep medicine as part of their ideal practice (P <. 05), while women more commonly reported pediatric otolaryngology (P <. 05). There was a higher mean number of ideal practice areas among men than women (2.58 vs 2.1, P <. 001).ConclusionThere is a growing trend for more specialized otolaryngology practices. The data demonstrate a decline in considering general and pediatrics otolaryngology as part of practices, which portends a gap in access to comprehensive otolaryngology in the future.