bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monetary Policy, Inflation Outlook, and Recession Probabilities
Authors: Vazquez-Grande Francisco , Ajello Andrea , Benzoni Luca , Schwinn Makena , Timmer Yannick 
Published: July 2022

An inverted yield curve—defined as an episode in which long-maturity Treasury yields fall below their short-maturity counterparts—is a powerful near-term predictor of recessions. While most previous studies focus on the predictive power of the spread between long- and short-maturity Treasury yields, Engstrom and Sharpe (2019) have recently shown that a measure of the nominal near-term forward spread (NTFS), given by the difference between the six-quarter-ahead forward Treasury yield and the current three-month Treasury bill rate, dominates long-term spreads as a leading indicator of economic activity.
Potential risk factors of atrial fibrillation recurrence after cryoballoon ablation
Authors: Novikov I. A. , Novikov P. S. , Mironov N. U. , Layovich L. Yu. , Malkina T. A. , Shariya M. A. , Sokolov S. F. , Maykov E. B. 
Published: July 2022

Aim To identify risk factors for recurrence of atrial fibrillation (AF) following cryoballoon ablation (CBA).Material and methods This prospective study included patients with paroxysmal AF who had undergone CBA (141 patients, median age 60 years, 3% men). The evaluation prior to CBA included clinical instrumental parameters (electrocardiography (ECG), 24-h ECG monitoring, echocardiography, contrast-enhanced cardiac multispiral computed tomography). Also, possible intraoperative indexes that could affect the CBA effectivity, were evaluated. The postoperative follow-up duration was 12 months. Effectivity was assessed during in-person visits at 3, 6, and 12 months, when questioning of patients and 24-h ECG monitoring were performed. CBA was considered ineffective if the patient had recurrences of any atrial tachyarrhythmia longer than 30 sec after the end of the 3-month “blind” period.Results During the 12-month follow-up, recurrences of atrial tachyarrhythmia were observed in 46 (32.6 %) patients. Patients with ineffective CBA more frequently had AF during the first 3 months (71.7 % vs. 11.6 %; р<0.001). Such patients had a history of multiple ineffective treatments with antiarrhythmic drugs (AAD), common pulmonary venous (PV) collector (41.3 % vs. 20.0 %; р=0.008), and stroke/recurrent ischemic attacks (15.2 % vs. 5.2 %; р=0.047). Multifactorial regression analysis showed that the factors of AF recurrence included common PV collector (relative risk (RR) 2.35; 95 % confidence interval (CI) 1.29–4.25; р=0.005), multiple ineffective AADs (RR 1.42; 95 % CI 1.08–1.86; р=0.011), and early AF recurrence (RR 7.57; 95 % CI 3.84–14.90; р<0.001).Conclusion Common PV collector and multiple ineffective AADs are risk factors of ineffective CBA. Early recurrences during the first 3 postoperative months are a significant risk factor of long-term AF recurrences.
Correlations between vessel stiffness and biomarkers of senescent cell in elderly patients
Authors: Sorokina A. G. , Efimenko A. Yu. , Grigorieva O. A. , Novoseletskaya E. S. , Basalova N. A. , Aleksandrushkina N. A. , Vigovskiy M. A. , Kirillova K. I. , Strazhesko I. D. , Orlov A. V. , Balatskiy A. V. , Samokhodskaya L. М. , Danilova N. V. , Dychkova U. D. , Akopyan A. A. , Kakotkin V. V. , Asratyan D. A. , Akopyan Z. A. , Orlova Ya. A. 
Published: July 2022

Aim To study the association between vascular wall stiffness and known markers for accumulation of senescent cells in blood, cells, and tissues of old patients.Material and methods This study included male and female patients aged 65 years and older who were referred to an elective surgical intervention, that included a surgical incision in the area of the anterior abdominal wall or large joints and met the inclusion and exclusion criteria. For all patients, traditional cardiovascular (CV) risk factors and arterial wall stiffness (pulse wave velocity, PWV) were evaluated. Also, biomaterials (peripheral blood, skin, subcutaneous adipose tissue) were collected during the surgery and were used for isolation of several cell types and subsequent histological analysis to determine various markers of senescent cells.Results The study included 80 patients aged 65 to 90 years. The correlation analysis identified the most significant indexes that reflected the accumulation of senescent cells at the systemic, tissue, and cellular levels (r>0.3, р<0.05) and showed positive and negative correlations with PWV. The following blood plasma factors were selected as the markers of ageing: insulin-like growth factor 1 (IGF-1), fibroblast growth factor 21 (FGF-21), and vascular endothelium adhesion molecule 1 (VCAM-1). A significant negative correlation between PWV and IGF-1 concentration was found. Among the tissue markers, P16INK, the key marker for tissue accumulation of senescent cells, predictably showed a positive correlation (r=0.394, p<0.05). A medium-strength correlation with parameters of the 96-h increment of mesenchymal stromal cells and fibroblasts and a weak correlation with IL-6 as a SASP (specific senescent-associated secretory phenotype) were noted. Results of the multifactorial linear regression analysis showed that the blood plasma marker, VCAM-1, and the cell marker, 96-h increment of fibroblasts, were associated with PWV regardless of the patient’s age.Conclusion Stiffness of great arteries as measured by PWV significantly correlates with a number of plasma, tissue, and cellular markers for accumulation of senescent cells. This fact suggests PWV as a candidate for inclusion in the panel of parameters for evaluation and monitoring of the biological age during the senolytic therapy.
Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: systematic review and meta-analysis
Authors: Mareev V. Yu. , Mareev Yu. V. , Begrambekova Yu. L. 
Published: July 2022

Aim The aim of the study was evaluation of the effect of the coenzyme Q10 (Q10) treatment on all-cause and cardiovascular mortality of patients with chronic heart failure (CHF). Q-10 increases the electron transfer in the mitochondrial respiratory chain and exerts anti-inflammatory and antioxidant effects. These effects improve the endothelial function and reduce afterload, which facilitates the heart pumping function. Patients with reduced left ventricular (LV) ejection fraction (EF) (CHFrEF) have low Q10.Material and methods Criteria of inclusion in the meta-analysis: 1) placebo-controlled studies; 2) enrollment of at least 100 patients; 3) publications after 2010, which implies an optimal basic therapy for CHF; 4) duration of at least 6 months; 5) reported cardiovascular and/or all-cause mortality; 6) using sufficient doses of Q10 (>100 mg/day). The search was performed in CENTRAL, MEDLINE, Embase, Web of Science, E-library, and ClinicalTrials.gov databases. All-cause mortality was the primary efficacy endpoint in this systematic review and the meta-analysis. The secondary endpoint was cardiovascular mortality. Meta-analysis was performed according to the Mantel-Haenszel methods. The Cochrane criterion (I2) was used for evaluation of statistical heterogeneity. The random effects model was used at I2≥50 %, whereas the fixed effects model was used at I2<50.Results Analysis of studies published from 01.01.2011 to 01.12.2021 identified 357 publications, 23 of which corresponded to the study topic, but only 6 (providing results of four randomized clinical trials, RCT) completely met the predefined criteria. The final analysis included results of managing 1139 patients (586 received Q10 and 553 received placebo). Risk of all-cause death was analyzed by data of four RCTs (1139 patients). The decrease in the risk associated with the Q10 treatment was 36 % (OR=0.64, 95 % CI 0.48–0.87, р=0.004). The heterogeneity of studies was low (Chi2=0.84; p=0.84; I2=0 %). Risk of cardiovascular mortality was analyzed by data of two RCTs (863 patients). The decrease in the risk associated with the Q10 treatment was significant, 55% (OR=0.45, 95 % CI: 0.32–0.64, р=0.00001). In this case, the data heterogeneity was also low (Chi2=0.41; p=0.52; I2=0 %).Conclusion The meta-analysis confirmed the beneficial effect of coenzyme Q10 on the prognosis of patients with CHFrEF receiving the recommended basic therapy.
Federal guidelines on diagnosis and treatment of chronic obstructive pulmonary disease
Authors: Chuchalin A. G. , Avdeev S. N. , Aisanov Z. R. , Belevskiy A. S. , Leshchenko I. V. , Ovcharenko S. I. , Shmelev E. I. 
Published: July 2022

Currently, chronic obstructive pulmonary disease (COPD) is a global health issue and one of the leading causes of death in the world. COPD therapy includes pharmacological and non-pharmacological approaches that can significantly improve clinical symptoms and reduce frequency of exacerbations of the disease.Methodology. The target audience of these clinical recommendations are therapists, general practitioners, and pulmonologists. Each thesis-recommendation about diagnostic and therapeutic procedures was graded according to the scales of classes of recommendations from 1 to 5 and the A, B, C scale of the levels of evidence. The clinical recommendations also contain comments and explanations to the theses together with algorithms for the diagnosis and treatment of COPD.Conclusion. The presented clinical guidelines cover the latest information about the etiology and pathogenesis, clinical manifestations, diagnosis, treatment, and prevention of chronic obstructive pulmonary disease. These guidelines were approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation in 2021.
A cross-sectional study to analysis perception of threat COVID 19 among doctors, nursing staff and medical technicians working at tertiary care canter during COVID-19 pandemic
Authors: Chouhan Vijay , Chaturvedi Manish , Narayan Parmar , Sharma Rahul 
Published: July 2022

Front line healthcare workers are the primary section in contact with patients and are an important source of exposure to the infected cases in the healthcare settings, thus expected to be at a high risk of infections. Lack of knowledge for a new disease’ infection, or pandemic among health care personnel may result in form of delayed treatment and rapid spirit of infection. : The study amid to find out the perfection of health care providers about COVID-19 the objectives of our study are to identify the perceived levels of stress and anxiety in the confined population to determine the experiences and psychosocial problems health care providers and to provide health education messages while taking part in the study. This is a cross-sectional study conducted on 100 frontline health care workers that include Doctors, nurses, and clinical technicians in all departments who work in Covid dedicated hospital and covid dedicated health care center at government medical college Ratlam. The survey instrument constituted a Semi-structured pre-tested 27-close ended questionnaire. The 27-item questionnaire was divided into two sections (1) baseline sociodemographic information (20 items) (2) perceptions of the threat of COVID-19 (7 items 5 statements/5-point Likert scales. In this study total of 118 health care providers/workers (HCWs) participated, 100 of whom completed the study questionnaire including 16 females and 84 men. The age of participants ranges from 20-to 50 years. After analysis of a total of seven-factor for perception to covid, we found that health care workers experienced different levels of psychological stress and anxiety. Government higher authority and policymakers should keep point in their mind that pandemics/outbreaks lead to stress, anxiety and depression among health care workers hence policymakers will need to develop a well-integrated administrative and psychological response to the occupational along with psychological challenges that are caused by future pandemic/outbreaks of this nature, to maintain better patient wellbeing.
A study to observe the effectiveness of 10 days of Yoga program on reaction time and student’s perception of the introduction of Yoga training in the MBBS course curriculum
Authors: Goothy Sai Sailesh Kumar , Choudhary Anita , Rathore Siddharth , Mahadik Vijay Khanderao 
Published: July 2022

Yoga was introduced to the MBBS curriculum on 12 June 2022. There is a need to obtain the perceptions of the students about this introduction of yoga training in their curriculum.The present study was undertaken to observe the effectiveness of 10 days of the Yoga program on reaction time and to obtain the perceptions of first-year MBBS students about the introduction of Yoga training in the MBBS course curriculum. A total of 150 first-year MBBS students studying at R.D. Gardi Medical College were part of the study after obtaining the voluntary, written, informed consent. Willing participants who practiced yoga for 10 days as per the protocol of NMC were recruited in the present study. The common protocol for Yoga was prepared by the Morarji Desai Institute of Yoga under the Ministry of Ayush. Auditory reaction time for high and low pitch sounds, and visual reaction time for red and green light were recorded using the RT apparatus for research manufactured by Anand Agencies, Pune. Both right-hand and left-hand responses were recorded. A standard questionnaire was used to record the perceptions of the students about the introduction of Yoga training in the MBBS course curriculum. Both auditory and visual reaction times were decreased followed by the yoga program. The majority of the students agreed that yoga offers multiple beneficial effects. The majority of the students agreed that yoga practice has many psychological benefits. The majority of the students agreed that the overall effect of yoga was much beneficial. The majority of the students reported that major barriers were lack of motivation and lack of time for yoga. The majority of students agreed positively that the inclusion of yoga in the curriculum was beneficial to them.The present study results explained that there was a decrease in the reaction time followed by yoga practice. The majority of students invited the move by the apex body incorporating Yoga in the curriculum.
Comparing and analysing working memory and its adjustments with classical instrumental background music in adolescents of diverse ethical origin – An RCT
Authors: Herlekar Shantala Shripad 
Published: July 2022

Students use variety of music while studying. The aim was to analyse effect of instrumental, background music on working memory in medical students of Indian and Malaysian origin.Age and gender matched 120 1st-year MBBS students (60 Indian and 60 Malaysian), were randomised into music and control groups equally. Music used was non vocal flute, raga malkauns. After 5 min of music/rest, working memory was assessed using Rey-Ostherrieth-complex-figure-test (ROCF). After another concentration task(SDMT) and a gap of 25min, recall of figure was assessed. Copy and recall figures were scored for 36 points.(significant p value&#60;0.05).There was no statistical difference between copy and recall score of ROCF when compared between music and control group of both ethnicities (p=0.223). Malaysian students performed significantly better in copy and recall score compared to Indian students.Instrumental music does not seem to influence working memory, but it does not hamper it too. As a diverse population, Malaysian students are bestowed with efficient working memory than Indian students. Music has no differential influence on the working memory of the two ethnic groups. Students can be advised to use instrumental music, preferably of raga Malkauns, in background while studying which will not hamper their retention.
Novel innervation of accessory slip of lateral head of gastrocnemius muscle
Authors: Muthiyan Gayatri , Kasat Payal Arvind , Tarnekar Aaditya , Sontakke Bharat , Deshmukh Vishwajit , Arivalagan Arunkumar 
Published: July 2022

The two heads of the gastrocnemius muscle, as well as the plantaris and soleus muscles, forms the superficial muscular group in the posterior compartment of the leg. The incidental occurrence of accessory slip of the lateral head of the gastrocnemius muscle in the right lower limb, innervated by a twig from the common peroneal nerve, is described in this report. We identified an anomalous 8 cm long muscle in the right popliteal fossa during standard academic dissection of a male corpse at the Department of Anatomy. It was attached to the lateral side of the femur's popliteal surface proximally and joined the lateral head of the gastrocnemius distally. In the left lower limb, no similar variation was observed.
The effect of short peptides on the growth and yield of soybeans
Authors: Aseeva T. A. , Khavinson V. Kh. , Mironova E. S., , Ryzhak G. A. , Selezneva N. A., , Fedorova T. N. 
Published: July 2022

Aim. Study of the effect of short di‐ and tetrapeptides (AB‐0, AE‐0) on the growth, development and productivity of Batya soybean varieties.Material and Methods. Biologically active dipeptide AB‐0 and tetrapeptide AE‐0 were used. Field studies were carried out on meadow‐brown podzolized gley heavy loamy soil. One month before planting, soybean seeds were treated with dipeptide/tetrapeptide of concentrations of 0.01 g/l or 0.001 g/l. Hand‐tended and industrial‐level research was carried out.Results. The use of dipeptide AB‐0 in a hand‐tended study had a positive effect on the growth processes of soybeans of the Batya variety compared to the control. The use of tetrapeptide AE‐0 in a hand‐tended study increased the weight of plants by 7.3‐67.0 g and plant height by 3.0‐9.0 cm compared to the control. The use of dipeptide AB‐0 and tetrapeptide AE‐0 increased the yield of soybeans by a maximum of 81.2‐83.7% compared to the control. The use of peptides AB‐0 and AE‐0 in an industrial‐level experiment increased the yield by 30.5% and 18.4%, respectively, compared with the control.Conclusion. The short peptides AB‐0 and AE‐0 studied had an impact on the growth, development and productivity of Batya soybean varieties. They can be classified as plant growth regulators.
The role of ROH in the etiopathogenesis of complex diseases
Authors: Omarova D. K. , Adieva A. A. , Bulaeva K. B. , Guseynova N. O. , Amirkhanova I. V. , Dzhamalova S. A. 
Published: July 2022

Aim. To carry out a comparative analysis of the main directions of genetic studies of complex (chronic) human neuropsychiatric diseases and to determine the prospects for their genomic studies.Discussion. Complex diseases account for more than 90% of the total human pathology and are the main cause of premature death and disability. One of the most urgent and severe categories of complex diseases, both for the patients themselves and for society, are endogenous mental illnesses, in particular, schizophrenia, mental retardation and autism spectrum disorders. Despite the fact that genetic and epidemiological studies show high heritability rates (up to 70‐80%), the identification of predisposition genes remains a challenge. Studies in recent decades have contributed to understanding the genetic mechanisms of the pathogenesis of such diseases and have significantly advanced our understanding in terms of identifying risk loci, possible mechanisms for the transmission of genetic risk, and the involvement in the pathogenesis of such diseases of not one but of a large number of genes that provide many variants of gene expression. However, the mapping of genes that control such clinical phenotypes and mutations in them that cause pathogenesis remains largely unknown.Conclusion. The finding of the same gene changes in neuropsychiatric complex diseases suggests that the genes involved converge in biochemical pathways and may be caused by a complex interplay of genetic and environmental factors characterized by genetic heterogeneity, which is often associated with clinical heterogeneity, incomplete penetrance and phenocopies. This is of great importance for the development of gene therapy through the identification of drug targets for the treatment of these disorders.
Materials on the Lepidoptera fauna of the Dagestan Republic (Northeastern Caucasus, Russia): spring aspect. Families Coleophoridae, Pterophoridae, Pyralidae, Crambidae, Drepanidae, Geometridae, Sphingidae, Saturniidae, Notodontidae, Erebidae & Noctuidae
Authors: Yakovlev R. V. , Teymurov A. A. , Kurbanova N. S. , Anikin V. V. , Matov A. Yu. , Morozov P. S. , Naydenov A. E. , Spitsyn V. M. , Streltsov A. N. , Ustjuzhanin P. Ya. 
Published: July 2022

Aim. To clarify the spring aspect of the faunistic composition of Lepidoptera insects in the Republic of Dagestan as one of the most poorly studied regions of the European part of Russia.Materials and Methods. The collection of material was carried out in six localities of the Republic of Dagestan at light sources and with a butterfly net. The material was determined using modern guides.Results. We have determined 210 species of the families: Coleophoridae, Pterophoridae, Pyralidae, Crambidae, Drepanidae, Geometridae, Sphingidae, Saturniidae, Notodontidae, Erebidae and Noctuidae. Thirteen species are indicated for the fauna of Eastern Caucasus for the first time: Trypostela machinopis (Meyrick, 1936), Multicoloria vibicigerella (Zeller, 1839), Casignetella ancistron (Falkovitsh, 1976) (Coleophoridae), Gymnancyla gilvella (Ragonot, 1887) (Pyralidae), Hypena obesalis (Treitschke, 1829) (Erebidae), Clostera pigra (Hüfnagel, 1766) (Notodontidae), Cleora cinctaria ([Denis & Schiffermüller], 1775), Chlorissa pretiosaria (Staudinger, 1887), Acasis viretata (Hübner, [1799]), Earophila badiata ([Denis & Schiffermüller], 1775), Pareulype berberata ([Denis & Schiffermüller], 1775), Eupithecia assimilata (Doubleday, 1856) and Eupithecia intricata (Zetterstedt, 1839) (Geometridae).Conclusion. It seems very perspective to study the entomofauna of the Republic of Dagestan, especially in non‐standard periods: in spring and autumn.
The scale of seasonal migrations in the urban part of the Great Tit population in the southeast of the West Siberian plain
Authors: Frolov I. G. 
Published: July 2022

Aim. This research aims to study the Great Tit breeding density, depending on the distance from preferred wintering sites with all other things being equal.Material and Methods. 36 route counts were carried out in 22 locations ranging up to 95 km away from the preferred wintering sites. The data was collected in the same weather and climatic zone. The route counts were carried out in the wintering season (January) and in the breeding season (16 April – 15 May) in 2014‐2018. To consider the influence of small settlements, where a smaller number of tits spends winter in comparison with a large city, sample sites were characterized by the population of people living within a radius of 25 km around the sample site.Results. Most Great Tits prefer to minimise the distance from their wintering sites to their nesting sites. The most preferred distance of seasonal movement is 10‐20 km from a large city, the main wintering place for this species.Conclusions. The density of the Great Tit population during the nesting period increases exponentially with the proximity of wintering sites. When more than 20 km from wintering sites, the density of the species during the nesting period does not change reliably. The maximum immanent density during the nesting period is achieved in places of favourable wintering of the species, that is, in a metropolis with agglomeration.