bluuebunny/crossref_metadata_2025_split huggingface dataset:
Control and complications of diabetes in urban primary care units in Thailand: a cross-sectional study
Authors: Puangpet Thanapat , Pongkunakorn Tanyaporn , Chulkarat Nahathai , Bunlangjit Chutikan , Surawit Apinya , Pinsawas Bonggochpass , Mongkolsucharitkul Pichanun , Mayurasakorn Korapat 
Published: March 2022

Abstract
Background: Primary health care system plays a central role in caring for persons with diabetes. Thai National Health Examination Survey (NHES) reports that only 40% of patients with type 2 diabetes mellitus (T2DM) achieve optimal glycemic control. We sought to evaluate the quality of diabetic care (QOC), prevalence of microvascular complications, and associated risk factors among T2DM patients treated at primary care units in urban areas in Thailand.Methods: A population-based, cross-sectional study of 488 T2DM patients aged over 35 years from 25 primary care units in Samutsakhon, Thailand was conducted during February 2018 to March 2019. Clinical targets of care (TOC) and processes of care (POC) were measured to evaluate QOC. Logistic regression models were applied to explore the association between risk factors and glycemic control.Results: 41.2% of women and 44.4% of men achieved hemoglobin A1C (A1C) < 53 mmol/mol, while 31.3% of women and 29.7% of men had poor glycemic control (A1C > 63 mmol/mol). 39 participants (8%) achieved all TOC and 318 participants (65.2%) achieved all POC. Significant risk factors for poor glycemic control included diabetes duration > 6 years (AOR = 1.83, 95% CI = 1.20-2.79), being overweight (AOR = 2.54, 95% CI = 1.58-4.08), obesity (AOR = 1.69, 95% CI = 1.00-2.86), triglycerides > 1.7 mmol/l (AOR= 1.68, 95% CI = 1.08-2.62), and low density lipoprotein-cholesterol (LDL-C) ≥ 2.6 mmol/l (AOR = 1.53, 95% CI = 1.00-2.35). Diabetic retinopathy was significantly related to obesity (AOR = 2.21, 95% CI = 1.00-4.86), over waist circumference (AOR = 2.23, 95% CI = 0.77-2.31), and diastolic blood pressure > 90 mmHg (AOR = 1.81, 95% CI = 1.48-1.96).Conclusion: Access to essential diabetic screening in primary care units is crucial to determine status of disease control and guide disease management. Duration of T2DM, high body mass index, triglyceride and LDL-C were independently associated with poor glycemic control. Obesity was highly associated with diabetes retinopathy. Effort should be taken seriously toward monitoring these factors and providing effective care.
Surgical treatment of uremic tumoral calcinosis: a case report and concise review of the literature
Authors: ZHENG Shi-wei , SUN Biao , LIU Chao , HU Xuefu 
Published: March 2022

Abstract
Uremic tumoral calcinosis (UTC) is a severe complication in patients undergoing maintenance hemodialysis.It is characterized by massive ectopic periarticular deposition of calcium–phosphorus compounds, especially around the weightbearing joints.We herein describe a 39-year-old uremic female on long-term continuous ambulatory hemodialysis for 8 years who developed UTC in the right gluteal region,featuring severe soreness and restriction of her right hip joint. She underwent incomplete surgical excision, showing typical tumoral calcinosis on histology, resolved the clinical symptoms.In addition, we conducted a pertinent literature search on PubMed,EBSCO, Ovid LWW and Springer database on the basis of the keywords “tumoral calcinosis”, without any time restriction, than we identified additional articles by reviewing the citations of published articles on the topic.We present a concise review on the etiology, pathogenesis, histological characteristics, diagnosis, available treatment options and overall systemic management of this particular disease based on the literature search.
Higher blood nicotine concentrations following smokeless tobacco (pituri) and cigarette use linked to adverse pregnancy outcomes for central Australian Aboriginal pregnancies
Authors: Ratsch Angela , Bogossian Fiona , Burmeister Elizabeth A , Ryu BoMi , Steadman Kathryn 
Published: March 2022

Abstract
Background: In central Australia, Aboriginal women use wild tobacco plants, Nicotiana spp. (locally known as pituri) as a chewed smokeless tobacco, with this use continuing throughout pregnancy and lactation. Our aim was to describe the biological concentrations of nicotine and metabolites in samples from mothers and neonates and examine the relationships to maternal self-reported tobacco use, maternal and neonatal outcomes.Methods: Central Australian Aboriginal mothers (and their neonates) who planned to birth at the Alice Springs Hospital (Northern Territory, Australia) provided biological samples: maternal blood, arterial and venous cord blood, amniotic fluid, maternal and neonatal urine, and breast milk. These were analysed for concentrations of nicotine and five metabolites.Results: A sample of 73 women were enrolled who self-reported: no-tobacco use (n=31), tobacco chewing (n=19), or smoking (n=23). Not all biological samples were obtained from all mothers and neonates. In those where samples were available, higher total concentrations of nicotine and metabolites were found in the maternal plasma, urine, breast milk, cord bloods and Day 1 neonatal urine of chewers compared with smokers and no-tobacco users. Tobacco-exposed mothers (chewers and smokers) with elevated blood glucose had higher nicotine and metabolite concentrations than tobacco-exposed mothers without elevated glucose, and this was associated with increased neonatal birthweight. Neonates exposed to higher maternal nicotine levels were more likely to be admitted to Special Care Nursery. By Day 3, urinary concentrations in tobacco-exposed neonates had reduced from Day 1, although these remained higher than concentrations from neonates in the no-tobacco group.Conclusions: This research provides the first evidence that maternal pituri chewing results in high nicotine concentrations in both the mother and neonate and that exposure may be associated with adverse maternal and neonatal outcomes similar to those from smoked tobacco use in pregnancy. Screening for the use of a broader range of tobacco and nicotine products during pregnancy would provide a more inclusive assessment and contribute to a more accurate determination of tobacco exposure. This knowledge will better inform maternal and foetal care, and direct attention to targeted cessation strategies that are appropriate to the tobacco and nicotine use profile of the population.Note to readers: In this research, the central Australian Aboriginal women chose the term ‘Aboriginal’ to refer to themselves, and ‘Indigenous’ to refer to the broader group of Australian First Peoples. That choice has been maintained in the reporting of the research findings.
Cost-effectiveness of colorectal screening in a European country. A comparison of five alternative screening strategies
Authors: Lopes Luís , Certo Manuela , Veiga Paula , Canena Jorge 
Published: March 2022

Abstract
BackgroundThe implementation of an organized screening strategy should include a cost-effectiveness analysis for the governments to take decisions that promote health and better allocate resources which does not happen most of the times. This study aimed to evaluate the most cost-effective strategy for CRC screening in a European Country.MethodsA cost-effectiveness (CE) probabilistic Markov model was developed to compare the costs and the quality-adjusted life expectancy of 50-year-old average-risk individuals submitted to five alternative screening strategies based on colonoscopy, computed tomography (CT) and FIT, as well as no screening. We calculated the costs from the perspective of a third payer (Portuguese National Health Service) and populated the model with data from published literature. Probability of being cost-effective was estimated for different thresholds of willingness-to-pay.ResultsColonoscopy 3/10 years is the most cost-effective strategy for colorectal screening in Portugal, with an estimated ICER of 802 €/ QALY when compared with colonoscopy every 10 years. The FIT and CT colonography based strategies are dominated by colonoscopy-based strategies. Biennial FIT, the strategy currently being used in Portugal, showed the smallest gains in life years gained (498.3 days) the smallest reduction in the incidence of CRC (-37%) and the smallest reduction in CRC mortality (-57%) between all the screening strategies. The findings were robust to probabilistic sensitivity analysis.ConclusionsColonoscopy based strategies offer the best value for the money in Portugal. Biennial FIT, the screening strategy in Portugal should be replaced by a colonoscopy-based strategy.
Synthesis and application of N_doped FeNi3/TiO2 nano-photocatalyst in advanced oxidation process to remove reactive red 195 dye from aqueous medium
Authors: Sahebdadzehi Z. , Khodadadi M. , Dorri H. 
Published: March 2022

Abstract
Dyes are one of the most dangerous chemical compounds in industrial wastewater, including textile wastewater. Reactive dyes have many applications in the textile industry. Nevertheless, due to the high solubility and stability of these dyes in water, the discharge of wastewater containing these dyes to receiving waters prevents the transmission of sunlight to aquatic environments and disrupts biological processes. The aim of this study was to synthesize N_doped FeNi3/TiO2 nano-photocatalyst and to investigate the removal efficiency of reactive red 195 dye from aqueous medium. In this study, the effect of important variables was investigated including initial concentration including pH (3-11), contact time (5 - 200 minutes), dye concentration (5 - 40 mg l-1), and nanocomposite dose (1 - 6 g l-1), in removal of reactive red 195 dye. The characteristics of the synthesized nanocomposites were also studied using BET, FTIR, FESEM, and VSM techniques. The results of this study revealed that increasing the contact time and decreasing the dye concentration enhanced the adsorption efficiency. The highest percentage of RR 195 dye adsorption was 82% after 90 minutes at the adsorbent concentration of 4 g l-1, pH=3 and the initial concentration of RR 195 of 5 mg l-1. Detection techniques also confirmed the synthesis of good quality synthesized nanocomposites. According to the results, the advanced oxidation process of N-doped FeNi3/Tio2 nano-photocatalyst had a high efficiency removal of reactive red 195 dye adsorption from aqueous medium. As a result, this method can be used effectively in the treatment of colored wastewater.
Predictors of Cord Blood Unit Cell Content in a Volume Unrestricted Large Series Collections: a Chance for a Fast and Cheap Multiparameter Selection Model
Authors: Fumarola Stefania , Lucarini Alessandra , Lucchetti Giovanna , Piroli Luana , Pierelli Luca 
Published: March 2022

Abstract
Background
Cord blood plays a very important role in stem cell transplantation and therapy, with an emerging implication also in regenerative medicine. The number of cells available in a single cord blood unit (CBU), in particular the CD34 + and total nucleated cell (TNC) content, influences the transplantation clinical outcome. We analysed a very large series of CBUs, collected for private banking without any specific volume restriction, to deeply investigate the best predictors of cord blood stem cells content.
Methods
Maternal and neonatal clinic laboratory data of a total 2583 UCBs were obtained from the InScientiaFides cord blood bank based in Republic of San Marino. Univariate and multivariate analysis were conducted to better interpret the data and to build a predictive model to select, the CBU with high CD34 + content.
Results
Our univariate analysis show that seasonality and the geographical area affect the quality of umbilical cord blood. Gestational age, babie’s gender and birth weight have a positive correlation with CB TNC content. The babie’s birth weight affect positively also CD34 + content and CBU volume while the cesarean delivery affect the CB volume only. Our predictive model, based on multivariate analysis, shows that male babie’s, gestational age lower to 39 weeks, cesarean delivery and CBUs with a content of TNC higher than 3,44x 108 (group A) have a significant higher CD34 + content than group B (female babie’s, gestational age higher than 39 weeks and vaginal delivery). The group A have a 37,5% of CBUs with a concentration of CD34 + > 2x106, while no CBUs with high concentration of CD34 + were detect in group B.
Conclusion
This study, conducted on a very large series of CBUs without any specific volume constraint, highlighted the prenatal and maternal factors that significantly influence the quality of the CBU collected. Specifically, it highlights that volume is not the best predictor of CD34 + CBU content; for this reason it cannot be taken into consideration alone for the analysis of the collected samples. Our final aim is to identify relevant factors, immediately available, that help to choice UCB with high CD34 + cell content, especially in simultaneous deliveries.
Multi-omic Characterization of Pediatric ARDS via Nasal Brushings
Authors: Williams James Garrett , Joshi Rashika , Haslam David , Yehya Nadir , Jones Rhonda L. , Paranjpe Aditi , Pujato Mario , Roskin Krishna M. , Lahni Patrick M. , Varisco Brian M. 
Published: March 2022

Abstract
RationaleWhile nasal brushing transcriptomics can identify disease subtypes in chronic pulmonary diseases, it is unknown whether this is true in pediatric ARDS (PARDS).ObjectivesDetermine whether nasal transcriptomics and methylomics can identify clinically meaningful PARDS subgroups that reflect important pathobiological processes.MethodsNasal brushings and serum were collected on days 1, 3, 7, and 14 from control and PARDS subjects from two centers. PARDS duration was the primary endpoint.Measurements and Main ResultsTwenty-four control and 39 PARDS subjects were enrolled. Two nasal methylation patterns were identified. Methyl Subgroup 1 had hypomethylation of cell adhesion genes and had only PARDS subjects. Methyl Subgroup 2 contained PARDS and control subjects with hypomethylation of cell metabolism genes. Neither methylation pattern had longer PARDS duration. Four transcriptomic patterns were identified with temporal patterns indicating injury, repair, and regeneration. Over time, both inflammatory (Subgroup B) and cell injury (Subgroup D) patterns transitioned to repair (Subgroup A) and eventually homeostasis (Subgroup C). Control specimens were largely Subgroup C. In comparison with 17 serum biomarkers, the nasal transcriptome was more predictive of prolonged PARDS. Initial Transcriptomic Subgroup B or D subjects had median PARDS duration of 8 days compared to 2 in A or C (p=0.02). For predicting PARDS duration ≥ 3 days, nasal transcriptomics was more sensitive and serum biomarkers more specific. ConclusionsPARDS nasal transcriptome may reflect distal lung injury, repair, and regeneration. A combined nasal PCR and serum biomarker assay could be useful for predictive and diagnostic enrichment.RegistrationClinicaltrials.gov NCT#03539783 May 29, 2018
Hydrogen gas alleviates Lipopolysaccharide-induced Acute Lung Injury and inhibits inflammatory response
Authors: Wei Youzhen , Yin Hongling , Feng Yajing , Duan Yi , Ma Shaolin , Guo Zhongliang 
Published: March 2022

Abstract
Background: The two main causes of body inflammation caused by lipopolysaccharide (LPS) -induced acute lung injury (ALI) are chronic inflammation and oxidant / antioxidant imbalances. Hydrogen (H2), a gaseous molecule without known toxicity, could react with hydroxyl radical to remove the reactive oxygen species (ROS). Both in vivo and vitro studies support the protective effect of hydrogen on injuries caused by oxidative stress and inflammations. Methods: In vivo study, mice were randomly divided into three groups: H2 control group, LPS group and LPS+H2 group. The mice were euthanized at the indicated time points and the specimens were collected. The 72h survival rates, cytokines contents, pathological changes, expression of Toll-like receptor 4(TLR4) and oxidative stress indicators were observed. In vitro study, according to different culture conditions, RAW 264.7 mouse macrophages were divided into the following groups: PBS group, LPS group and LPS+H2 group. The cell Viability, intracellular ROS, cytokines and expression of TLR4 and nuclear factor kappa-B (NF-κB) were observed. Results: In vivo, the 72h survival rate of hydrogen inhalation mice was increased to 80%, and H2 significantly lighten LPS-induced lung damages and decreased inflammatory cytokine release. Besides, H2 showed remarked anti-oxidative activity to reduce the MDA and NO contents in lung. In vitro, H2 down-regulated the levels of ROS, NO, TNF-α, IL-6 and IL-1β in LPS-stimulated macrophages. Second, H2 inhibited the expression of TLR4 and the activation of nuclear factor kappa-B (NF-κB). In summary, these findings supported that H2 attenuates LPS-induced inflammatory responses, which may be mediated by TLR4-NF-κB pathway.
Research on Temperature Control System of Capacitor Hot Press Based on Improved Particle Swarm Optimization
Authors: Wang Qiang , Zhang Feng 
Published: March 2022

Abstract
In the production of film capacitors, the temperature control of the capacitor hot press is very important. PID control algorithm is widely used in the capacitor hot press. However, traditional PID control algorithm often has difficulty setting parameters. It is not suitable for such a large hysteresis and nonlinear temperature control system. Through the research of traditional PID control algorithm, Particle Swarm Optimization (PSO) algorithm and fuzzy control algorithm, an improved particle swarm algorithm is proposed, and the Improved Particle Swarm Optimization (IPSO) algorithm is applied in the fuzzy PID temperature control system. The temperature control system is simulated by MATLAB. The research results show that the fuzzy PID temperature control system based on IPSO is superior to other temperature control system in terms of adjustment time, overshoot and anti-interference ability.
Current status of and barriers to liver cancer treatment in China: a questionnaire-based study from the perspective of doctors
Authors: Wei Qiaoxin , Zhou Haiyang , Hou Xinhui , Liu Xiaoping , Chen Sisi , Huang Xueying , Chen Yu , Liu Mei , Duan Zhongping 
Published: March 2022

Abstract
Background : Liver cancer is a severe public health problem worldwide, and it creates a relatively higher disease burden in China than in the Western world. Despite achieving notable progress in China, potential imbalances in some aspects of medical services for liver cancer may persist across different regions and hospitals. This warrants serious consideration of the actual status of and barriers to liver cancer treatment. We intended to explore the present status of and obstacles in liver cancer treatment.Methods: In February 2021, a national multicenter cross-sectional study was conducted among 1,500 doctors from 31 provinces of mainland China using a self-administered online questionnaire. All doctors completed the questionnaire about their general information, perspectives on the current status of liver cancer treatment, and expectations for future treatment. Chi-square and logistic regression analyses were performed to explore the differences caused by the regions, professional titles, and hospital levels of the doctors. Results: Treatment conditions, medications, and treatment strategies were inconsistent across different economic regions and hospitals of varied levels. With respect to obstacles in treatment, 76.59% of the doctors were unsatisfied with the current treatment for liver cancer. Important factors that influenced their satisfaction with the treatment for liver cancer included early diagnosis and the disclosure of true conditions to patients.Conclusions: There persists unevenness in the treatment of liver cancer in China, besides barriers to treatment. Researchers should pay attention to the detection and treatment of liver cancer and the propagation of novel progress among doctors in underdeveloped areas.
A modified pipe model improved the accuracy of crown biomass estimation in a larch (Larix olgensis) plantation forest in northeast China
Authors: Huang Chenyu , Chen Lu , Zhuang Liwen , Sang Weiguo 
Published: March 2022

Abstract
Pipe model theory has the potential to be widely applied in the estimation of tree allometry parameters, although it remains uncertain whether it can provide accurate estimation of the crown biomass of plantation forest. In this study, an improved pipe model was used for the first time to estimate the crown biomass of Larix olgensis plantations in northeast China. The results of linear regression analysis showed that crown biomass could be accurately estimated from the stem area at the crown base, which could be calculated using the tree height, crown base height, and stem area at breast height. Furthermore, covariance analysis was applied to analyze the differences in site-related factors that affect crown biomass. There was no significant difference between sites in the crown biomass of L. olgensis plantations in the research area, while the effect of tree age on crown biomass estimation should be considered. Our study showed that a modified pipe model could accurately estimate the crown biomass of larch plantations in northeast China, which has great significance for the determination of crown biomass in Chinese plantations using pipe model theory.
Anti-inflammatory effect of N-(trifluoromethylphenyl)-2-cyano-3-hydroxy-crotonic acid amide and Gluconic acid on Allergic Rhinitis and Asthma controlling
Authors: Liu Xing , Nasab Entezar Mehrabi , Athari Seyyed Shamsadin 
Published: March 2022

Abstract
Allergic rhinitis and asthma are main airway disease with a higher prevalence. Eosinophilic inflammation, airway hyper-responsiveness, mucus hyper-secretion, and reversible airflow obstruction are immunopathogenesis symptoms of rhinitis and asthma. Crotonic acid has bioactivity on the inflammation and Gluconic acid as chelator may protect crotonic acid activity in airway and with together may control allergic rhinitis and asthma. Allergic rhinitis and asthma mice were treated with crotonic and gluconic acid. At least, total IgE, histamine, IL-4, IL-5, and IL-13 levels were measured. In lung tissues, goblet cell hyperplasia, mucus hyper-secretion, and inflammation were evaluated.The level of IL-5, Goblet cell hyperplasia, perivascular and peribronchial inflammation were controlled by crotonic in asthma and allergic rhinitis groups. But total IgE, histamine, IL-4, IL-13 levels and Mucus hyper-secretion had no significant chenges between treated and non-treated asthma and rhinitis groups.Crotonic acid can control eosinophilic inflammation via harnessing of IL-5 and prevent goblet cell hyperplasia. When it was used with gluconic acid, had strong effect on control of allergic rhinis and asthma immunopathology.