bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduktion
Authors: Haslund Helle , Wind Gitte 
Published: June 2022

I dette nummer af Tidsskrift for Forskning i Sygdom og Samfund sæ er vi fokus på børn; fra de for tidligt fødte til den unge som er på vej ind i et gryende vok- senliv. Hvordan børns sygdom påvirker hverdagsliv, mening, identitet, relationer og forældreskab, samt hvilken betydning det får i velfærdsstaten synes at hænge sammen med en stadig mere udbredt fortælling om barndom og ungdom som sårbare livsstadier, der afspejles i et velfærdsstatsligt fokus på det ́gode ́ børneliv. Vi undersøger i de e særnummer børns sundhed, sygdom og erfaringer - altså hvordan børns sygdom og sundhed de neres, optræder, forstås og håndteres af børnene selv og i samspil med forældre og omsorgspersoner, af sundhedsvæsenet og af det omkringliggende samfund. Vi har også fokus på børn som slægtninge – eller deres transformation til pårørende – og undersøger, hvad det betyder for børn at leve med en syg forælder. De sociale og institutionelle praksisser, der om- giver børns sundhed og sygdom, og de værdier og normer, der er på spil angående børns sygdom og sundhed, står centralt i de e særnummer.
Strontium Substituted Tricalcium Phosphate Bone Cement: Short and Long‐Term Time‐Resolved Studies and In Vitro Properties
Authors: Rau Julietta V. , Fadeeva Inna V. , Forysenkova Anna A. , Davydova Galina A. , Fosca Marco , Filippov Yaroslav Yu. , Antoniac Iulian V. , Antoniac Aurora , D'Arco Annalisa , Di Fabrizio Marta , Petrarca Massimo , Lupi Stefano , Di Menno Di Bucchianico Massimo , Yankova Viktoriya G. , Putlayev Valery I. , Cristea Mihai Bogdan 
Published: June 2022

AbstractDue to a significant influence of strontium (Sr) on bone regeneration, Sr substituted β‐tricalcium phosphate (Sr‐TCP) cement is prepared and investigated by short‐ and long‐term time‐resolved techniques. For short‐term investigations, energy‐dispersive X‐ray diffraction, infrared spectroscopy, and, for the first time, terahertz time‐domain spectroscopy techniques are applied. For long‐term time‐resolved studies, angular dispersive X‐ray diffraction, scanning electron microscopy, mechanical tests, and behavior in Ringer solution are carried out. After 45 min of the cement setting, the Sr‐TCP phase is no longer detectable. During this time period, an appearance and constant increase of the final brushite phase are registered. The compressive strength of the Sr‐TCP cement increases from 4.5 MPa after 2 h of setting and reaches maximum at 13.3 MPa after 21 d. After cement soaking for 21 d in Ringer solution, apatite final product, with an admixture of brushite and TCP phases is detected. The cytotoxicity aspects of the prepared cement are investigated using NCTC 3T3 fibroblast cell line, and the cytocompatibility—by human dental pulp mesenchymal stem cells. The obtained results allow to conclude that the developed Sr‐TCP cement is promising for biomedical applications for bone tissue.
Self‐Powered Intelligent Voice Navigation Tactile Pavement Based on High‐Output Hybrid Nanogenerator
Authors: Jiang Dongjie , Du Minxing , Qu Xuecheng , Gai Yansong , Sun Wei , Xue Jiangtao , Li Yusheng , Li Zhou , Wang Zhong Lin 
Published: June 2022

AbstractImproving the safety and usability of the blind movement is of great significance. The blind navigation system has always been the focus of attention. However, achieving an unconscious interaction and long‐term operation with high navigation accuracy is an urgent challenge. In this study, a distributed self‐powered intelligent voice navigation tactile pavement (SVP) based on a hybrid nanogenerator for blind navigation is reported. More than 4‐s effective output time is achieved under a single instantaneous pressure to the hybrid nanogenerator. The system is integrated with an inertial storage hybrid nanogenerator (ISNG), RF transmitter module, and voice broadcast module. It has the advantages of outstanding navigation accuracy, fatigue resistance (16 000 cycles), temperature stability (−50 to 50 °C), no required operation, and easy fabrication. The SVP may solve the difficulties of GPS navigation delay and lack of map information and realize the accurate identification and feedback of key locations, providing an effective and unconscious interaction navigation strategy for the blind. Integrating the hybrid nanogenerator under the road can provide an energy supply for the construction of the Internet of Things and smart city in the future.
Diastereoselective and Synergistic Gold‐Catalyzed Bispropargylation of Xanthones and Thioxanthones: An Access to Xanthene Derivatives
Authors: Fernández Sergio , Allegue Darío , Santamaría Javier , Ballesteros Alfredo 
Published: June 2022

AbstractA gold‐catalyzed bispropargylation of xanthone derivatives is described. The use of propargylsilanes permits to achieve a deoxygenative bispropargylation through a double catalytic addition of the corresponding allenylgold intermediate to the synergistically activated carbonyl moiety. This methodology works in a diastereoselective manner either with xanthone or thioxanthone derivatives. Monopropargylated xanthydrol silyl ethers were isolated as reaction intermediates and these species could be transformed into symmetrical and non‐symmetrical bispropargylated xanthenes. The formation of non‐symmetrical bispropargylated xanthenes could also be achieved through an one‐pot procedure. Finally, other interesting structures, such as propargylxanthylidenes, propargylxanthenes and bispropargylated xanthenes replacing the silicon moiety, were accessible following different one‐pot synthetic methodologies. In addition, bispropargylated xanthenes could perform a carbonylative [2+2+1] formal cycloaddition.magnified image
Composted tobacco waste increases the yield and organoleptic quality of leaf mustard
Authors: Nguyen Binh The , Dinh Duyen Hong , Hoang Nam Ba , Do Thang Trong , Milham Paul , Thi Hoang Dung , Cao Son Truong 
Published: June 2022

AbstractTobacco (Nicotiana tabacum) waste is produced in many countries and is phytotoxic due to the alkaloid content; in Vietnam the waste is usually burned causing air pollution. We composted tobacco waste with chicken manure in different proportions—1 t of waste ± accelerant (C1 and C2); 0.8 t of waste + 0.2 t of chicken manure ± accelerant (C3 and C4); and 0.7 t of waste + 0.3 t of chicken manure ± accelerant (C5 and C6)—for 30 d in covered heaps. Three mixtures containing the accelerant (C2, C4, and C6) reached temperatures of ∼55 °C, that 5s, hot enough to suppress disease and weeds. Composting decreased the alkaloid content from ∼6,000 to ∼200 mg kg−1, and C4 with a C/N ratio of 19:1, was used in a field trial. The compost treatments (0, 10, 15, and 20 t ha−1) were combined fertilizer with phosphorus (40 kg ha−1), nitrogen (60 kg ha−1) and potassium (90 kg ha−1) for leaf mustard (Brassica integrifolia). The yield increased from ∼17 to ∼29 t ha−1 with the amount of compost applied, and the nitrate concentration decreased concomitantly from ∼67 to ∼42 mg NO3–N kg−1 fresh weight, presumably due to ongoing composting (nitrogen drawdown). Organoleptic evaluation showed a preference for the crops grown with the compost amendments. Whether remains to be seen whether one‐off compost applications >20 t ha−1 and repeated, large applications provide additional, long‐term production benefits, or if the benefits may be outweighed by the accumulation of persistent, phytotoxic alkaloids.
Dynamic change of fecal microbiota and metabolomics in a polymicrobial murine sepsis model
Authors: Muratsu Arisa , Ikeda Mitsunori , Shimizu Kentaro , Kameoka Shoichiro , Motooka Daisuke , Nakamura Shota , Matsumoto Hisatake , Ogura Hiroshi , Shimazu Takeshi 
Published: June 2022

AimSepsis causes a systemic inflammatory reaction by destroying intestinal flora, which leads to a poor prognosis. In this study, we sought to clarify the characteristics of fecal flora and metabolites in a mouse model of sepsis by comprehensive metagenomic and metabolomic analysis.MethodsWe performed a cecal ligation and puncture model procedure to create a mild sepsis model. We collected fecal samples on day 0 (healthy condition) and days 1 and 7 after the cecal ligation and puncture to determine the microbiome and metabolites. We analyzed fecal flora using 16S rRNA gene sequencing and metabolites using capillary electrophoresis mass spectrometry with time‐of‐flight analysis.ResultsThe abundance of bacteria belonging to the family Enterobacteriaceae significantly increased, but that of order Clostridiales such as the families Lachnospiraceae and Ruminococcaceae decreased on day 1 after the cecal ligation and puncture compared with those before the cecal ligation and puncture. The family Enterobacteriaceae significantly decreased, but that of order Clostridiales such as the families Lachnospiraceae and Ruminococcaceae increased on day 7 compared with those on day 1 after the cecal ligation and puncture. In the fecal metabolome, 313 metabolites were identified. Particularly, essential amino acids such as valine and non‐essential amino acids such as glycine increased remarkably following injury. Betaine and trimethylamine also increased. In contrast, short‐chain fatty acids such as isovaleric acid, butyric acid, and propionic acid decreased.ConclusionThe fecal microbiota following injury showed that Enterobacteriaceae increased in acute phase, and Lachnospiraceae and Ruminococcaceae increased in subacute phase. The metabolites revealed an increase in essential amino acids and choline metabolites and a decrease in short‐chain fatty acids.
Data‐Driven Interpretable Descriptors for the Structure–Activity Relationship of Surface Lattice Oxygen on Doped Vanadium Oxides
Authors: Jiang Chenggong , Song Hongbo , Sun Guodong , Chang Xin , Zhen Shiyu , Wu Shican , Zhao Zhi‐Jian , Gong Jinlong 
Published: June 2022

AbstractUnderstanding the structure–activity relationship of surface lattice oxygen is critical but challenging to design efficient redox catalysts. This paper describes data‐driven redox activity descriptors on doped vanadium oxides combining density functional theory and interpretable machine learning. We corroborate that the p‐band center is the most crucial feature for the activity. Besides, some features from the coordination environment, including unoccupied d‐band center, s‐ and d‐band fillings, also play important roles in tuning the oxygen activity. Further analysis reveals that data‐driven descriptors could decode more information about electron transfer during the redox process. Based on the descriptors, we report that atomic Re‐ and W‐doping could inhibit over‐oxidation in the chemical looping oxidative dehydrogenation of propane, which is verified by subsequent experiments and calculations. This work sheds light on the structure–activity relationship of lattice oxygen for the rational design of redox catalysts.
Effect of Surface‐Adsorbed and Intercalated (Oxy)anions on the Oxygen Evolution Reaction
Authors: Hausmann J. Niklas , Menezes Prashanth W. 
Published: June 2022

AbstractAs the kinetically demanding oxygen evolution reaction (OER) is crucial for the decarbonization of our society, a wide range of (pre)catalysts with various non‐active‐site elements (e.g., Mo, S, Se, N, P, C, Si…) have been investigated. Thermodynamics dictate that these elements oxidize during industrial operation. The formed oxyanions are water soluble and thus predominantly leach in a reconstruction process. Nevertheless, recently, it was unveiled that these thermodynamically stable (oxy)anions can adsorb on the surface or intercalate in the interlayer space of the active catalyst. There, they tune the electronic properties of the active sites and can interact with the reaction intermediates, changing the OER kinetics and potentially breaking the persisting OER *OH/*OOH scaling relations. Thus, the addition of (oxy)anions to the electrolyte opens a new design dimension for OER catalysis and the herein discussed observations deepen the understanding of the role of anions in the OER.
Entropy‐Mediated Polymer–Cluster Interactions Enable Dramatic Thermal Stiffening Hydrogels for Mechanoadaptive Smart Fabrics
Authors: Wu Jia , Wu Baohu , Xiong Jiaqing , Sun Shengtong , Wu Peiyi 
Published: June 2022

AbstractThermal stiffening materials that are naturally soft but adaptively self‐strengthen upon heat are intriguing for load‐bearing and self‐protection applications at elevated temperatures. However, to simultaneously achieve high modulus change amplitude and high mechanical strength at the stiffened state remains challenging. Herein, entropy‐mediated polymer–mineral cluster interactions are exploited to afford thermal stiffening hydrogels with a record‐high storage modulus enhancement of 13 000 times covering a super wide regime from 1.3 kPa to 17 MPa. Such a dramatic thermal stiffening effect is ascribed to the transition from liquid‐liquid to solid–liquid phase separations, and at the molecular level, driven by enhanced polymer–cluster interactions. The hydrogel is further processed into sheath–core fibers and smart fabrics, which demonstrate self‐strengthening and self‐powered sensing properties by co‐weaving another liquid metal fiber as both the joule heater and triboelectric layer.
Cucurbituril‐Based Supramolecular Polymers for Biomedical Applications
Authors: Wang Ziyi , Sun Chen , Yang Kuikun , Chen Xiaoyuan , Wang Ruibing 
Published: June 2022

AbstractSupramolecular polymers (SPs) have attracted broad interest because of their intriguing features and functions. Host–guest interactions often impart tunable physicochemical properties, reversible hierarchical organization, and stimuli‐responsiveness to SPs for diverse biomedical applications. Characterized by strong but dynamic interactions with guest molecules, cucurbit[n]uril (CB[n]) has shown great potential as an important building block of various functional polymers for biomedical applications. In this Minireview, we summarize the most recent examples regarding the design, fabrication, and biomedical applications of CB[n]‐based supramolecular polymers (CSPs), which are categorized as noncovalent and covalent CSPs according to the interactions between the CB[n] and polymer backbones. The design principles of CSPs and their unique advantages for biomedical applications, as well as the developmental trends and future perspectives of this cross‐disciplinary area are also discussed.
Suppressing Non‐Radiative Relaxation through Single‐Atom Metal Modification for Enhanced Fluorescence Efficiency in Molybdenum Disulfide Quantum Dots
Authors: Li Chao‐Rui , Lei Yu‐Li , Li Hua , Ni Miao , Yang Dong‐Rui , Xie Xiao‐Yu , Wang Yuan‐Fan , Ma Hai‐Bo , Xu Wei‐Gao , Xia Xing‐Hua 
Published: June 2022

AbstractTo enhance the fluorescence efficiency of semiconductor nanocrystal quantum dots (QDs), strategies via enhancing photo‐absorption and eliminating non‐radiative relaxation have been proposed. In this study, we demonstrate that fluorescence efficiency of molybdenum disulfide quantum dots (MoS2 QDs) can be enhanced by single‐atom metal (Au, Ag, Pt, Cu) modification. Four‐fold enhancement of the fluorescence emission of MoS2 QDs is observed with single‐atom Au modification. The underlying mechanism is ascribed to the passivation of non‐radiative surface states owing to the new defect energy level of Au in the forbidden band that can trap excess electrons in n‐type MoS2, increasing the recombination probability of conduction band electrons with valence band holes of MoS2. Our results open an avenue for enhancing the fluorescence efficiency of QDs via the modification of atomically dispersed metals, and extend their scopes and potentials in a fundamental way for economic efficiency and stability of single‐atom metals.
N‐Substituted Arylidene‐3‐(Methylsulfonyl)‐2‐Oxoimidazolidine‐1‐Carbohydrazide as Cholinesterase Inhibitors: Design, Synthesis, and Molecular Docking Study
Authors: Tok Fatih , Sağlık Begüm Nurpelin , Özkay Yusuf , Kaplancıklı Zafer Asım , Koçyiğit‐Kaymakçıoğlu Bedia 
Published: June 2022

AbstractThe development of new enzyme inhibitors in degenerative brain diseases has gained more attention. Enzyme inhibitors play an effective role in controlling central nervous system diseases. For this purpose, a novel series of hydrazone derivatives containing imidazolidine ring aimed against Alzheimer's disease (AD), have been designed and synthesized. The acetylcholinesterase (AChE) enzyme inhibitory activity of these compounds was investigated. The structures of the compounds were determined by IR, 1H and 13C‐NMR and mass spectroscopic methods. Inhibition studies on the cholinesterase (ChE) enzymes and β‐amyloid plaque inhibition test of the compounds were performed. Based on the experimental results, compound 3j bearing dimethoxy substituent on the aromatic ring like donepezil exhibited the most AChE inhibitory activity with the IC50 values of 0.023±0.001 μM. Owing to obtained biological activity and molecular docking study results, it is thought that the most active compound 3j may play a role in both symptomatic and palliative treatment of AD.
Advances in the Key Metal‐Based Catalysts for Efficient Electrochemical Conversion of CO2
Authors: Darayen Jidsucha , Chailapakul Orawon , Praserthdam Piyasan , Panpranot Joongjai , Tungasmita Duangamol N. , Boonyongmaneerat Yuttanant 
Published: June 2022

AbstractThe electrochemical reduction process is one of the most promising approaches to both efficiently remove the important greenhouse gas CO2 and convert it to chemical products of high value. However, in addition to the configuration of electrochemical cells, electrocatalysts are main factors affecting key performances in electrochemical CO2 reduction reactions. Recently, studies have been conducted to investigate the roles of metal‐based electrocatalysts and improve their performances through alloying, oxidization, and microstructural modulations. This review comprehensively discusses and analyzes the developments made in such metal‐based electrocatalyst studies and presents the advancements of important metals for use in electrochemical CO2 reduction processes. The relationships between the electrodes' microstructure, chemistry, and efficiency in CO2 conversion are also compared and discussed.
Scutellarin‐mediated autophagy activates exosome release of rat nucleus pulposus cells by positively regulating Rab8a via the PI3K/PTEN/Akt pathway
Authors: Hu Shun‐Qi , Zou Yan‐Pei , Jiang Yun‐Qi , Zhang Qi‐Chen , Cheng Hong‐Xia , Wang Hui‐Ren , Li Xi‐Lei 
Published: June 2022

AbstractTo provide a basis for promising exosome‐based therapies against intervertebral disc degeneration (IDD), our present research aimed to identify a mechanism underlying the vesicle release from nucleus pulposus cells (NPCs). Scutellarin (SC) is a natural chemotherapeutic agent isolated from Erigeron breviscapus with a variety of biological activities. Here, we observed the significantly elevated autophagy levels in rat NPCs under the stimulation of SC, leading to a concomitant enhancement of intracellular vesicle release, which could be attributed to the inactivation of the phosphoinositide 3‐kinase (PI3K)/phosphatase and tensin homolog (PTEN)/protein kinase B (Akt) pathway. To ensure that exosome release was driven by SC via the autophagic pathway, we implemented gain‐of‐function and loss‐of‐function studies by additionally using insulin‐like growth factor‐1 (IGF‐1) and small‐interfering RNA of autophagy‐related gene 5 (ATG5), and the exosome secretion decreased in the case of attenuated autophagy. Evidently, the treatment with SC exerted the remarkable upregulation of Rab8a through the overexpression of ATG5. After the respective knockdown of ATG5 and Rab8a, the increased release of exosomes induced by SC was reversed, whereas the number of intracellular vesicles was restored. Overall, it can be concluded that SC contributes to the autophagy activation in NPCs by acting on the PI3K/PTEN/Akt pathway, which upregulates the expression of Rab8a and promotes the release of exosomes, inspiring novel therapeutic strategies in preventing IDD that might be fruitfully investigated.
Waste‐Derived Copper‐Lead Electrocatalysts for CO2 Reduction
Authors: Yang Shuang , An Hongyu , Anastasiadou Dimitra , Xu Wenjie , Wu Longfei , Wang Hui , de Ruiter Jim , Arnouts Sven , Figueiredo Marta C. , Bals Sara , Altantzis Thomas , van der Stam Ward , Weckhuysen Bert M. 
Published: June 2022

AbstractIt remains a real challenge to control the selectivity of the electrocatalytic CO2 reduction (eCO2R) reaction to valuable chemicals and fuels. Most of the electrocatalysts are made of non‐renewable metal resources, which hampers their large‐scale implementation. Here, we report the preparation of bimetallic copper‐lead (CuPb) electrocatalysts from industrial metallurgical waste. The metal ions were extracted from the metallurgical waste through simple chemical treatment with ammonium chloride, and CuxPby electrocatalysts with tunable compositions were fabricated through electrodeposition at varying cathodic potentials. X‐ray spectroscopy techniques showed that the pristine electrocatalysts consist of Cu0, Cu1+ and Pb2+ domains, and no evidence for alloy formation was found. We found a volcano‐shape relationship between eCO2R selectivity toward two electron products, such as CO, and the elemental ratio of Cu and Pb. A maximum Faradaic efficiency towards CO was found for Cu9.00Pb1.00, which was four times higher than that of pure Cu, under the same electrocatalytic conditions. In situ Raman spectroscopy revealed that the optimal amount of Pb effectively improved the reducibility of the pristine Cu1+ and Pb2+ domains to metallic Cu and Pb, which boosted the selectivity towards CO by synergistic effects. This work provides a framework of thinking to design and tune the selectivity of bimetallic electrocatalysts for CO2 reduction through valorization of metallurgical waste.
Proton Conduction at High Temperature in High‐Symmetry Hydrogen‐Bonded Molecular Crystals of RuIII Complexes with Six Imidazole‐Imidazolate Ligands
Authors: Tadokoro Makoto , Itoh Masaki , Nishimura Ryota , Sekiguchi Kensuke , Hoshino Norihisa , Kamebuchi Hajime , Miyazaki Jun , Kobayashi Fumiya , Mizuno Motohiro , Akutagawa Tomoyuki 
Published: June 2022

AbstractA new H‐bonded crystal [RuIII(Him)3(Im)3] with three imidazole (Him) and three imidazolate (Im−) groups was prepared to obtain a higher‐temperature proton conductor than a Nafion membrane with water driving. The crystal is constructed by complementary N−H⋅⋅⋅N H‐bonds between the RuIII complexes and has a rare Icy‐c* cubic network topology with a twofold interpenetration without crystal anisotropy. The crystals show a proton conductivity of 3.08×10−5 S cm−1 at 450 K and a faster conductivity than those formed by only HIms. The high proton conductivity is attributed to not only molecular rotations and hopping motions of HIm frameworks that are activated at ∼113 K, but also isotropic whole‐molecule rotation of [RuIII(Him)3(Im)3] at temperatures greater than 420 K. The latter rotation was confirmed by solid‐state 2H NMR spectroscopy; probable proton conduction routes were predicted and theoretically considered.
CO2 Separation by Imide/Imine Organic Cages
Authors: La Cognata Sonia , Mobili Riccardo , Milanese Chiara , Boiocchi Massimo , Gaboardi Mattia , Armentano Donatella , Jansen Johannes C. , Monteleone Marcello , Antonangelo Ariana R. , Carta Mariolino , Amendola Valeria 
Published: June 2022

AbstractTwo novel imide/imine‐based organic cages have been prepared and studied as materials for the selective separation of CO2 from N2 and CH4 under vacuum swing adsorption conditions. Gas adsorption on the new compounds showed selectivity for CO2 over N2 and CH4. The cages were also tested as fillers in mixed‐matrix membranes for gas separation. Dense and robust membranes were obtained by loading the cages in either Matrimid® or PEEK‐WC polymers. Improved gas‐transport properties and selectivity for CO2 were achieved compared to the neat polymer membranes.