bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired Lower Limb Proprioception in Spinocerebellar Ataxia Type 3 and Its Affected Factors
Authors: Liu Xia-Hua , Wang Zhi-Yong , Li Ying , Xu Hao-Ling , Sikandar Arif , Ni Jun , Gan Shi-Rui 
Published: February 2022

BackgroundSpinocerebellar ataxia type 3 (SCA3) is one of the most common hereditary neurodegenerative diseases. Postural control dysfunction is the main symptom of SCA3, and the proprioceptive system is a critical sensory component of postural control. Accordingly, proprioception quantification assessment is necessary in monitoring the progression of SCA3.ObjectiveWe aimed to quantitatively assess lower limb proprioception and investigate the relationship between proprioception and clinical characteristics in patients with SCA3.MethodsA total of 80 patients with SCA3 and 62 health controls were recruited, and their lower limb proprioception was measured using the Pro-kin system. Clinical characteristics of the SCA3 patients were collected. Multivariable linear regression was used to investigate potential affected factors for lower limb proprioception.ResultsWe found that the patients with SCA3 experience poorer lower limb proprioception characterized by significant impairment in the average trace error (ATE) and time to carry out the test time execution (TTE) compared to controls (P &lt; 0.05). Moreover, there were significant differences in TTE between the right and left lower limbs (P &lt; 0.05) of the patients. Regression analyses revealed that increasing age at onset (AAO) predicts poorer lower limb proprioception for both ATE (β = 2.006, P = 0.027) and TTE (β = 1.712, P = 0.043) and increasing disease duration predicts poorer lower limb proprioception for ATE (β = 0.874, P = 0.044). AAO (β = 0.328, P = 0.019) along with the expanded alleles (β = 0.565, P = 0.000) could affect the severity of ataxia. By contrast, ATE (β = 0.036, P = 0.800) and TTE (β = −0.025, P = 0.862) showed no significant predictors.ConclusionsLower limb proprioception in patients with SCA3 is significantly impaired when compared to healthy controls. Increasing AAO and disease duration are related to impaired lower limb proprioception.
Nutritional Status and Dietary Intake of School-Age Children and Early Adolescents: Systematic Review in a Developing Country and Lessons for the Global Perspective
Authors: Khan Durray Shahwar A. , Das Jai K. , Zareen Shagufta , Lassi Zohra S. , Salman Afsah , Raashid Muhammad , Dero Aftab A. , Khanzada Aijaz , Bhutta Zulfiqar A. 
Published: February 2022

BackgroundThe prevalence of double burden of malnutrition (DBM) is high in low- and middle-income countries (LMICs). Data on malnutrition trends is present for children &lt;5 years of age, however the data for school-going children and adolescents aged 5–15 years is scarce.ObjectiveThis systematic review presents the pooled prevalence of nutritional status and dietary intake among school-going children and adolescents (5–15 years of age) in an LMIC of Pakistan and the perspective for broader global nutrition in this age group.MethodsAn electronic search of databases was run on Pubmed and Medline (via Ovid) along with gray literature and archives of local scientific journals till 2nd January 2021. Studies meeting the eligibility criteria were included and relevant data were extracted, and a pooled proportional analysis was performed.ResultsA total of 51 studies including 62,148 children of 5–15 years met the inclusion criteria, of which 30 studies reported on anthropometric indices alone, eight on dietary intake patterns while 13 reported both. All of the included studies had a cross-sectional study design. There were 20 studies from the province of Punjab, 15 from Sindh, eight from Khyber Pakhtoonkhwa, two from Balochistan, and three from multiple cities across Pakistan. The pooled proportional analysis showed that the proportion of underweight children and adolescents was 25.1% (95% CI 17.3–33.7%); stunting 23% (95% CI 11.8–36.7%); wasting 24% (95% CI 15.2–34%); thinness 12.5% (95% CI 9.4–16.1%); overweight 11.4% (95% CI 7.2–16.3%); and obesity 6.9% (95% CI 3–12%). A relatively high intake of carbohydrates, soft drinks, and sweets/chocolates; and a low intake of protein-rich foods, fruits, and vegetables, compared to the recommended daily allowance (RDA), was reported.ConclusionThe limited data suggests the presence of DBM amongst children aged 5–15 years and also identified that dietary intake patterns are not meeting the recommended allowance. This review highlights the gaps and the need for larger, well-designed studies for this age group with the representation of different contexts and the need for similar studies in various LMICs, so that appropriate actions be deliberated and appropriate programs should be designed focusing on this vital population.
Prognostic Nomogram for Rectal Cancer Patients With Tumor Deposits
Authors: Zhong Xiaohong , Wang Lei , Shao Lingdong , Zhang Xueqing , Hong Liang , Chen Gang , Wu Junxin 
Published: February 2022

AimTumor deposits (TDs) are an aggressive hallmark of rectal cancer, but their prognostic value has not been addressed in current staging systems. This study aimed to construct and validate a prognostic nomogram for rectal cancer patients with TDs.MethodsA total of 1,388 stage III–IV rectal cancer patients who underwent radical surgical resection from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed to identify the clinical value of TDs. TD-positive rectal cancer patients in the SEER database were used as the training set to construct a prognostic model, which was validated by Fujian Cancer Hospital. Three models were constructed to predict the prognosis of rectal cancer patients with TDs, including the least absolute shrinkage and selection operator regression (LASSO, model 1), backward stepwise regression (BSR, model 2), and LASSO followed by BSR (model 3). A nomogram was established among the three models.ResultsIn the entire cohort, TD was also identified as an independent risk factor for overall survival (OS), even after adjusting for baseline factors, stage, other risk factors, treatments, and all the included variables in this study (all P &lt; 0.05). Among patients with TDs, model 3 exhibited a higher C-index and area under the curves (AUCs) at 3, 4, and 5 years compared with the American Joint Committee on Cancer staging system both in the training and validation sets (all P &lt; 0.05). The nomogram obtained from model 3 showed good consistency based on the calibration curves and excellent clinical applicability by the decision curve analysis curves. In addition, patients were divided into two subgroups with apparently different OS according to the current nomogram (both P &lt; 0.05), and only patients in the high-risk subgroup were found to benefit from postoperative radiotherapy (P &lt; 0.05).ConclusionWe identified a novel nomogram that could not only predict the prognosis of rectal cancer patients with TDs but also provide reliable evidence for clinical decision-making.
Chinese Version of the mHealth App Usability Questionnaire: Cross-Cultural Adaptation and Validation
Authors: Zhao Shuqing , Cao Yingjuan , Cao Heng , Liu Kao , Lv Xiaoyan , Zhang Jinxin , Li Yuxin , Davidson Patricia M. 
Published: February 2022

BackgroundMobile health (mHealth) apps have shown the advantages of improving medication compliance, saving time required for diagnosis and treatment, reducing medical expenses, etc. The World Health Organization (WHO) has recommended that mHealth apps should be evaluated prior to their implementation to ensure their accuracy in data analysis.ObjectiveThis study aimed to translate the patient version of the interactive mHealth app usability questionnaire (MAUQ) into Chinese, and to conduct cross-cultural adaptation and reliability and validity tests.MethodsThe Brislin’s translation model was used in this study. The cross-cultural adaptation was performed according to experts’ comments and the results of prediction test. The convenience sampling method was utilized to investigate 346 patients who used the “Good Doctor” (“Good Doctor” is the most popular mHealth app in China), and the reliability and validity of the questionnaire were evaluated as well.ResultsAfter translation and cross-cultural adaptation, there were a total of 21 items and 3 dimensions: usability and satisfaction (8 items), system information arrangement (6 items), and efficiency (7 items). The content validity index was determined to be 0.952, indicating that the 21 items used to evaluate the usability of the Chinese version of the MAUQ were well correlated. The Cronbach’s α coefficient of the total questionnaire was 0.912, which revealed that the questionnaire had a high internal consistency. The values of test-retest reliability and split-half reliability of the Chinese version of the MAUQ were 0.869 and 0.701, respectively, representing that the questionnaire had a good stability.ConclusionThe translated questionnaire has good reliability and validity in the context of Chinese culture, and it could be used as a usability testing tool for the patient version of interactive mHealth apps.
Feet/Footwear-Related Fall Risk Screening Tool for Older Adults: Development and Content Validation
Authors: Wingood Mariana , Peterson Elizabeth , Neville Christopher , Vincenzo Jennifer L. 
Published: February 2022

Background and PurposeScreening for feet- and footwear-related influences on fall risk is an important component of multifactorial fall risk screenings, yet few evidence-based tools are available for this purpose. We developed the Screening Tool for Feet/Footwear-Related Influences on Fall Risk to support interprofessional health care providers in their efforts to screen for feet/footwear-related influences on fall risk among community-dwelling older adults identified at risk for falling.Materials and MethodsThe study consisted of two phases. During Phase 1, results of a systematic review of lower-limb factors associated with balance and falls informed tool development. The tool's initial draft was evaluated by an external group of nine interprofessional content experts. After incorporating changes recommended by Phase 1 participants, Phase 2 was initiated. During Phase 2, eight new interprofessional experts (19.3 average years of experience) completed the three rounds of a modified Delphi study.ResultsPhase 1 experts recommended modifying eight items and rated the tool's clarity, appeal and clinical feasibility as 81.2/100, 79.1/100, and 76.1/100, respectively. Phase 2 participants suggested combining items with similar recommended actions, adding a question about orthoses, and increasing the specificity of nine items. The refinements resulted in a 20-item screening tool. Each item was approved by the Phase 2 participants with &gt; 80% agreement after two rounds of consensus voting, reflecting the tool's high face and content validity.ConclusionThe new screening tool has high face and content validity and supports identification of feet- and footwear-related influences on fall risk among community-dwelling older adults. The tool can be used by interprofessional healthcare providers completing a multifactorial fall risk screening on community-dwelling adults identified as being at risk for falling.
Endoscopic vs. Microscopic Transsphenoidal Surgery for the Treatment of Pituitary Adenoma: A Meta-Analysis
Authors: Chen Jia , Liu Hongyan , Man Siliang , Liu Geng , Li Quan , Zuo Qingyao , Huo Lili , Li Wei , Deng Wei 
Published: February 2022

PurposeCurrently, endoscopic transsphenoidal surgery (ETS) and microscopic transsphenoidal surgery (MTS) are commonly applied treatments for patients with pituitary adenomas. This meta-analysis was conducted to evaluate the efficacy and safety of ETS and MTS for these patients.MethodsA computer search of Pubmed, Embase, Cochrane library, Web of Science, and Google Scholar databases was conducted for studies investigating ETS and MTS for patients with pituitary adenomas. The deadline is March 01, 2021. RevMan5.1 software was used to complete this meta-analysis after literature screening, data extraction, and literature quality evaluation.ResultsA total of 37 studies including 5,591 patients were included. There was no significant difference in gross tumor removal (GTR) and hormone-excess secretion remission (HES remission) between two groups [RR = 1.10, 95% CI (0.99–1.22), P = 0.07; RR = 1.09, 95% CI (1.00–1.20), P = 0.05]. ETS was associated with lower incidence of diabetes insipidus (DI) [RR = 0.71, 95% CI (0.58–0.87), P = 0.0008], hypothyroidism [RR = 0.64, 95% CI (0.47–0.89), P = 0.007], and septal perforation [RR = 0.32, 95% CI (0.13–0.79), P = 0.01] than those with MTS.ConclusionThis meta-analysis indicated that ETS cannot significantly improve GTR and HES remission. However, ETS could reduce the incidence of DI, hypothyroidism, and septal perforation without increasing the rate of other complications.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/#myprospero, identifier: CRD42021241217.
Uterine Artery Embolization on Serum β-HCG Levels, Fertility Function and Clinical Efficacy in Patients With Cesarean Uterine Scar Pregnancy
Authors: Zhu Wenyang , Zhang Xiaofang , Liu Chang , Liu Yang , Xu Wei 
Published: February 2022

ObjectiveTo analyze the therapeutic effect of uterine artery embolisation (UAE) in patients with cesarean section pregnancy (CSP) delivered by cesarean section and the effect on serum human chorionic gonadotrophin (β-HCG) levels and reproductive function.MethodsIn total 142 patients with CSP, The control group (n = 71) received Methotrexate (MTX) with ultrasound monitoring after admission and the research group (n = 71) was treated with UAE on basic of the control group. The two groups were compared in terms of treatment outcome, intraoperative bleeding, bed activity, vaginal bleeding and length of hospital stay, and serum follicle stimulating hormone (FSH), oestradiol (E2), luteinising hormone (LH) and β-HCG levels at 1 month postoperatively. The clinical symptoms (normalization of β-HCG and return of menstruation) and clinical outcomes (normal pregnancy, recurrent scar pregnancy) were compared between the two groups, as well as the occurrence of post-operative complications in both groups.ResultsCompared with the control group, the research group had a higher overall near-term effective rate, a lower recurrence rate of CSP in pregnancy, and a lower complication rate (P &lt; 0.05); meanwhile, the time to get out of bed, postoperative vaginal bleeding, length of hospital stay, normalization of serum β-HCG, and return to menstruation were shorter in the research group than in the control group (P &lt; 0.05); In addition, serum FSH, E2, LH and β-HCG levels improved better in the research group compared with the control group 1 month after surgery (P &lt; 0.05).ConclusionThe treatment of CSP patients with UAE can reduce the amount of intraoperative bleeding and the duration of vaginal bleeding, promote the improvement of patients' clinical symptoms, have less impact on the disruption of patients' sex hormone balance, reduce patients' surgical risks to a greater extent, preserve patients' normal fertility, and have better application.
Factores relacionados al transporte y logística pre-sacrificio bovino que generan impacto sobre la calidad de la carne y pérdidas económicas
Authors: Zambrano Garay Wilmer Humberto , Martínez Cepeda Galo Ernesto , García Ávila George Alexander , Zambrano Villacís Juan José 
Published: February 2022

El presente estudio tuvo como objetivo analizar algunos factores relacionados al transporte de bovinos previo al sacrificio, aportando datos relacionados al bienestar animal de los vacunos del Ecuador, y su impacto económico. Las variables dependientes fueron número de hematomas, decomiso de carne y pérdidas económicas; frente a variables independientes relacionadas a la mezcla de categorías, tipo de categoría, sexo, tipo de cama usada en el transporte y tiempo de viaje, al cual fueron sometidos los animales. Se evidenció que las hembras, específicamente las vacas y vaconas, fueron la categoría más afectada al ser sometidas a las variables de estudio; en contraposición, no se encontró evidencia de que los tiempos prolongados de viaje sean factores predisponentes de lesiones.

Palabras clave: bienestar animal; calidad de la carne; ganado bovino; transporte de animales.
Caída del paciente adulto mayor hospitalizado
Authors: Fuentes Méndez Alicia 
Published: February 2022

Las caídas en pacientes adultos mayores durante su estadía hospitalaria, son un hecho real que constituye un problema de salud, por su repercusión tanto a nivel personal como en costos institucionales, siendo la convergencia de distintos factores que las favorecen. El reconocer una caída es fundamental para poder instaurar oportunamente medidas destinadas a prevenirlas, así como para disminuir el daño secundario que pudiera alterar la rehabilitación del paciente. Objetivo. Proponer un protocolo de atención de enfermería para contribuir a prevenir la caída del adulto mayor durante su estadía hospitalaria. Materiales y Métodos: Se aplicaron las técnicas de la encuesta, entrevista y revisión de historiales clínicos, con la finalidad de conocer factores de riesgo que causan la caída y la percepsión sobre la atención resivida por el profesional al paciente durante su estadía hospitalaria. Resultados. La revisión de historiales clínicos evidenció el 10% de caídas, la encuesta aplicada reveló el 40% de factores extrínsecos, el 60% factores intrinsecos presentes y latentes en el hospital que ocacionan la caída, a la entrevista a pacientes adultos mayores manifiestan que por la sobrecarga de actividades y demanda de pacientes el profesional de enfermería no coadyuva con las necesidades de salud que ellos requieren, se sientes solos y abandonados. Conclusiones: Los resultados obtenidos de la investigación, fueron el camino para plantear una propuesta, sustentada en un modelo teórico que fundamenta e idealiza al proceso de atención de enfermería con sus componentes, para luego concretizar en un protocolo como documento normativo sustentado en la premisa del cuidado con calidad.
Efektivitas Penyuluhan Berbasis Whatsapp Terhadap Pengetahuan dan Praktek SADARI Saat Pandemi Corona
Authors: Fauziah Ani Nur , Maesaroh Siti , Suparti Sri 
Published: February 2022

SADARI atau pemeriksaan payudara sendiri (Breast Self-Examination / BSE) adalah pilihan cara pencegahan kanker payudara yang baik dilakukan, khususnya mulai usia 20-an. SADARI rutin memainkan peran besar dalam menemukan benjolan kanker payudara. Banyak mitos yang mengatakan bahwa kanker payudara lebih sering menyerang wanita yang sudah berusia di atas 30 tahun, tetapi kini banyak wanita pada usia remaja sudah menderita kanker payudara. Berdasarkan laporan WHO, pada tahun 2011 jumlah wanita khususnya remaja penderita kanker payudara mencapai 1.150.000 orang, 700.000 diantaranya tinggal di negara berkembangtermasuk Indonesia.Pengetahuan masyarakat yang kurang tentang kanker payudara membuat pencegahan dan penanganan secara dini mengalami kesulitan, apalagi disaat pandemi Corona memerlukan aplikasi media sosial untuk mendukungnya diantaranya adalah whatsapp. Penelitian ini bertujuan untuk mengetahui efektifitas penyuluhan kesehatan SADARI berbasis Whatsapp terhadap pengetahuan dan praktek SADARI saat pandemi Corona. Jenis penelitian adalah analitik dengan pendekatan waktu cross sectional. Subyek penelitian adalah mahasiswi Prodi S1 Farmasi STIKES Mamba’ul Ulum Surakarta sejumlah 37 orang. Selanjutnya analisis data menggunakan uji Uji -t berpasangan (peried t-test) dengan bantuan Program SPSS.Hasil penelitian menunjukkan bahwa penyuluhan kesehatan SADARI berbasis Hasil penelitian menunjukkan bahwa penyuluhan kesehatan SADARI berbasis aplikasi whatsapp efektif dalam peningkatan pengetahuan dan praktek SADARI saat pandemi Corona nilai ρ = 0.000
Integration of silicon nanowire bridges in microtrenches with perpendicular bottom-up growth promoted by surface nanoholes
Authors: Uesugi Akio , Nishiyori Shusuke , Nakagami Tatsuya , Sugano Koji , Isono Yoshitada 
Published: February 2022

Abstract
An integration method of silicon nanowires (SiNWs) bridges in microtrenches was demonstrated combining a local arrangement of catalyst Au nanoparticles by two-step UV lithography, and a vapor–liquid–solid (VLS) bottom-up growth with perpendicularity promotion by surface nanoholes with metal-assisted chemical etching. Au nanoparticles with a diameter of 60 nm were arranged on one-side walls of 10 µm wide microtrenches, with two types of area sizes to evaluate the influence on the yield of SiNWs bridges reaching opposite sidewalls. A four-hour VLS process at 500 °C produced perpendicular SiNWs bridges in the microtrenches, and a higher yield was obtained with a narrow-area arrangement: a 30.7% ratio of densities of SiNWs bridges to Au nanoparticles, and a 2.1/µm2 density in the arrangement area. Fewer SiNWs showed initial oblique growth there, and most of the bridges had a linear morphology. The yield of SiNWs bridges was discussed focusing on depth positions in microtrenches and the depths of surface nanoholes.
Unsupervised recycled FPGA detection using exhaustive nearest neighbor residual analysis
Authors: Isaka Yuya , Shintani Michihiro , Inoue Michiko 
Published: February 2022

Abstract
Measuring and analyzing aging-induced delay degradation of ring oscillators (ROs) is an effective method to detect recycled field-programmable gate arrays (FPGAs). However, detection methods of conventional recycled FPGAs detection methods assume the existence of known fresh FPGAs (KFFs) as training data for machine-learning-based classification, which is an unrealistic assumption. In this paper, we propose an unsupervised recycled FPGA detection method, where little information on KFF is available. In the proposed method, estimated frequency is calculated from neighboring ROs, and then the residual frequency between the measured and estimated frequencies is used for the detection. Because of the systematic component of process variation, the frequencies of neighboring ROs should be similar when the target FPGA is fresh. Therefore, if the residual is high, the target FPGA is determined as recycled. Experiments using 25 commercial FPGAs under various aging scenarios demonstrate that the proposed method successfully distinguishes between recycled and fresh FPGAs.
Large coercivity of 13 kOe in L10-ordered CoPt on Si/SiO2 substrates by hydrogen annealing
Authors: Toyama Ryo , Kawachi Shiro , Yamaura Jun-ichi , Murakami Youichi , Hosono Hideo , Majima Yutaka 
Published: February 2022

Abstract

L10-ordered CoPt with a large coercivity (H
c) of 13 kOe was demonstrated on Si/SiO2 substrates by hydrogen annealing. Equiatomic 11.2 nm thick (Co/Pt)4 multilayer thin films were fabricated by electron-beam evaporation and were annealed at 500 °C–900 °C for 10–90 min under an Ar/H2 mixed gas atmosphere. The annealing temperature and time dependences of the crystal structures, magnetic properties, and surface morphologies of the films were systematically analyzed based on the experimental results obtained from grazing incidence X-ray diffraction (GI-XRD), vibrating sample magnetometer, and scanning electron microscope, respectively. Hydrogen annealing effectively promoted the out-of-plane c-axis orientation of L10-ordered CoPt compared to the vacuum annealing according to the GI-XRD patterns. A maximum H
c of 13.3 kOe was obtained in L10-ordered CoPt with angular-outlined isolated grains by hydrogen annealing at 800 °C for 60 min, where the c-axis of L10-ordered CoPt was randomly distributed.