bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal sensitivity during mealtime and free play: Differences and explanatory factors
Authors: van Vliet Merel S. , Mesman Judi , Schultink Janneke M. , Vereijken Carel M. J. L. , Martens Vanessa E. G. , van der Veek Shelley M. C. 
Published: March 2022

AbstractMealtime is a parent–toddler interaction that occurs multiple times a day. This study examined whether observed maternal sensitivity differed between a mealtime and free‐play setting, aiming to explain differences between the two situations by studying moderating effects of children's eating behavior. The sample consisted of 103 first‐time mothers and their 18‐month‐old children. Maternal sensitivity was assessed by coding videotaped interactions of free‐play sessions and mealtimes, using the Ainsworth Sensitivity Scale (range 1–9). Additionally, child eating behavior during the meal was coded and also assessed through the Child Eating Behavior Questionnaire—Toddlers. First, a small but significant amount of stability was found between sensitivity during mealtime and sensitivity during play (r = 0.24). Second, mothers were more sensitive during free play (mean = 7.11) than during mealtime (mean = 6.52). Third, observed child eating behavior was related to maternal sensitivity during mealtime, with more food enjoyment being associated with higher levels of sensitivity, and more challenging child behavior with lower levels of sensitivity. Finally, when children showed a high degree of challenging behavior during the meal, there was more discrepancy between sensitivity during mealtime and free play. Our results highlight the importance of taking context into account when observing parental sensitivity.
A plant mannose-binding lectin and fluconazole: Key targets combination against Candida albicans
Authors: Del Rio Marianela , Radicioni Melisa B. , Mello Érica O. , Ribeiro Suzanna F. F. , Taveira Gabriel B. , Carvalho André O. , de la Canal Laura , Gomes Valdirene M. , Regente Mariana 
Published: March 2022

Aims
This study aimed to evaluate the combined effect of a mannose-binding lectin Helja with fluconazole (FLC) on Candida albicans and to get insights about the joint action mechanism.

Methods and Results
The fungal growth was assessed following the optical density at 630 nm. Fungal cell morphology and nucleus integrity were analysed by flow cytometry and confocal laser scanning microscopy using Calcofluor White (CFW) and 4′,6-diamidino-2-phenylindole (DAPI) staining respectively. The basis of Helja + FLC action on cell wall and plasma membrane was analysed using perturbing agents. The Helja + FLC combination exhibited an inhibitory effect of fungal growth about three times greater than the sum of both compounds separately and inhibited fungal morphological plasticity, an important virulence attribute associated with drug resistance. Cells treated with Helja + FLC showed morphological changes, nucleus disintegration and formation of multimera structures, leading to cell collapse.

Conclusions
Our findings indicate that the Helja + FLC combination exhibited a potent antifungal activity based on their simultaneous action on different microbial cell targets.

Significance and Impact of Study
The combination of a natural protein with conventional drugs might be helpful for the design of effective therapeutic strategies against Candida, contributing to minimize the development of drug resistance and host cell toxicity.
Psychological bases of anti‐immigration attitudes among populist voters
Authors: Pellegrini Valerio , Salvati Marco , De Cristofaro Valeria , Giacomantonio Mauro , Leone Luigi 
Published: March 2022

AbstractThe ascent of populism has been linked with economic and cultural disruptions of modernization. From this perspective, it could be implied that factors such as psychological insecurity and uncertainty are key in making voters gravitate toward the populist narrative. The present research aimed at highlighting the psychological determinants that uncertainties deriving from modernization processes may activate in populist voters. Specifically, we focused on immigration in Italy, investigating whether and how support for different populist parties relates to development of negative attitudes toward immigrants. Two samples of Italian adults (total N = 1655), who voted in the Italian general elections of March 4, 2018 took part in the research. Multigroup path analysis showed that assumption of anti‐immigration stances through the joint mediating role of Dangerous World Belief and Right‐Wing Authoritarianism was shared by different groups of populist voters. However, different populist voters differed in the strength of the path passing through Competitive Jungle World Belief and Social Dominance Orientation. Results underline the relevance of social worldviews and ideological attitudes in shaping the attitudes of the Italian populist electorate.
Financial versus strategic bidders and underpricing as an acquisition motive
Authors: Salva Carolina , Zhang Xiqian 
Published: March 2022

AbstractWe examine the difference between financial and strategic bidders in exploiting target underpricing. To isolate underpricing from other sources of acquisition gain, we estimate the target revaluation of bids that fail to be completed. We document larger revaluations for targets of financial bidders, precisely private equity bidders than for those of strategic bidders when targets are most likely to be underpriced, that is, when they are small. This differential effect between financial and strategic bidders in target revaluation is robust after controlling for differential sorting into deal failure, future takeover activity and anticipated operational changes and therefore indicates that it is greater target underpricing before bid announcements that financial bidders reveal to the market than strategic bidders do. This suggests that financial bidders and private equity firms attempting to buy smaller firms are more likely associated with underpriced targets than strategic bidders.
A millennium of climatic and floristic dynamics in the Eastern Cordillera of the Colombian Andes
Authors: Correa‐Metrio Alex , Escobar Jaime , Bird Broxton W. , Caballero‐Rodríguez Dayenari , Steinman Byron A. , Rodríguez‐Zorro Paula A. , Curtis Jason 
Published: March 2022

AbstractAimThe transition from the Medieval Climate Anomaly (MCA, 950–1250 CE) to the Little Ice Age (LIA, 1350–1800 CE) is the largest pre‐industrial climate shift within the last two millennia, offering an opportunity to study how vegetation responds to rapid climate change. We analysed a sedimentary record from the Colombian Andes to reconstruct regional vegetation dynamics during this time interval, identify the modern environmental distribution of taxa present in the fossil record and provide a reference for modern regional temperature change.LocationLake Tota, Eastern Cordillera, Colombian Andes.TaxonAngiosperm and Gymnosperms.MethodsA sediment core was analysed for organic geochemistry and pollen to reconstruct environmental and vegetation variability between 800 and 1800 CE. Modern occurrences of individuals of the genera found in the fossil record were used to model the distribution of taxa across gradients of mean annual temperature and precipitation. These models were used to reconstruct temperature and precipitation across time and evaluate the probability of occurrence of taxa from the fossil record across the contemporary landscape.ResultsReconstructed regional vegetation dynamics were highly coupled with global temperature patterns. Reconstructed climate showed that conditions were warm and dry during the MCA, and cold and relatively wet during the LIA, although quantitative estimations might have been amplified by human disturbances. Rates of temperature change during the MCA‐LIA transition were substantially lower than those calculated for the last two decades. Vegetation turnover between 800 and 1800 CE resembled those expressed through a transect extending ~30 km southeast from the lake.Main conclusionsAround lake Tota, modern rates of temperature change have no precedent within the last two millennia. The modern environmental affinities of taxa involved in vegetation turnover during the MCA‐LIA transition point to the importance of landscape diversity and connectivity for rapid vegetation response to climate change.
Radiofrequency ablation using a novel insulated‐tip ablation catheter can create uniform lesions comparable in size to conventional irrigated ablation catheters while using a fraction of the energy and irrigation
Authors: Aryana Arash , Irastorza Ramiro M. , Berjano Enrique , Cohen Richard J. , Kraus Jeffrey , Haghighi‐Mood Ali , Reddy Vivek Y. , d'Avila André 
Published: March 2022

AbstractIntroductionDuring radiofrequency ablation (RFA) using conventional RFA catheters (RFC), ~90% of the energy dissipates into the bloodstream/surrounding tissue. We hypothesized that a novel insulated‐tip ablation catheter (SMT) capable of blocking the radiofrequency path may focus most of the energy into the targeted tissue while utilizing reduced power and irrigation.MethodsThis study evaluated the outcomes of RFA using SMT versus an RFC in silico, ex vivo, and in vivo. Radiofrequency applications were delivered over porcine myocardium (ex vivo) and porcine thigh muscle preparations superfused with heparinized blood (in vivo). Altogether, 274 radiofrequency applications were delivered using SMT (4–15 W, 2 or 20 ml/min) and 74 applications using RFC (30 W, 30 ml/min).ResultsRFA using SMT proved capable of directing 66.8% of the radiofrequency energy into the targeted tissue. Accordingly, low power–low irrigation RFA using SMT (8–12 W, 2 ml/min) yielded lesion sizes comparable with RFC, whereas high power–high irrigation (15 W, 20 ml/min) RFA with SMT yielded lesions larger than RFC (p < .05). Although SMT was associated with greater impedance drops ex vivo and in vivo, ablation using RFC was associated with increased charring/steam pop/tissue cavitation (p < .05). Lastly, lesions created with SMT were more homogeneous than RFC (p < .001).ConclusionLow power–low irrigation (8–12 W, 2 ml/min) RFA using the novel SMT ablation catheter can create more uniform, but comparable‐sized lesions as RFC with reduced charring/steam pop/tissue cavitation. High power–high irrigation (15 W, 20 ml/min) RFA with SMT yields lesions larger than RFC.
Vein of Marshall alcohol ablation for dormant pulmonary vein conduction: A case report
Authors: Janga Chaitra , Madhavan Malini , Siontis Konstantinos C. , Killu Ammar M. 
Published: March 2022

AbstractWe report a case of alcohol ablation into a vein of Marshall for recurrent dormant conduction into the pulmonary veins with adenosine testing in a patient where two prior ablation attempts failed to isolate the left vein.
On the profitability of interfirm bundling in oligopolies
Authors: Kim Sang‐Hyun , Hahn Jong‐Hee 
Published: March 2022

AbstractThis paper examines the profitability of interfirm bundling among independent single‐good producers in a two‐dimensional Hotelling framework. We show that interfirm bundling tends to relax price competition by preventing consumers from mixing and matching (i.e., making it difficult to switch brands) and therefore is more profitable than separate sales, provided that firms are sufficiently symmetric. Hence, firms have mutual incentives to offer their products as a bundle or to make exclusive dealing arrangements. This result sheds new light on the competitive effect of bundling in oligopolies that have been neglected in the literature.
miR‐144‐3p/miR‐451a promotes lymphovascular invasion through repression of PTEN/p19 in rectal neuroendocrine tumors
Authors: Murayama Noriaki , Okamoto Koichi , Nakagawa Tadahiko , Miyoshi Jinsei , Nishida Kensei , Kawaguchi Tomoyuki , Kagemoto Kaizo , Kitamura Shinji , Ma Beibei , Miyamoto Hiroshi , Muguruma Naoki , Yano Mitsuyasu , Tsuneyama Koichi , Fujimori Takahiro , Sato Yasushi , Takayama Tetsuji 
Published: March 2022

AbstractBackground and AimAlthough rectal neuroendocrine tumor (NET‐G1) have potential metastatic capability, even among small tumors, no predictive biomarker for invasion and metastasis has been reported. We analyzed microRNA (miRNA) expression profiles in rectal NET‐G1 tissues with and without lymphovascular invasion (LVI). Moreover, we then investigated their target genes to clarify the mechanism of invasion/metastasis in NET‐G1.MethodsmiRNA array analysis was performed using seven rectal NET‐G1 tissues with LVI and seven without LVI. miRNA expression was confirmed by quantitative real‐time PCR. A NET cell line H727 was transfected with miRNA mimic or target gene small interfering RNA, and migration and invasion assays were performed.ResultsThe expression levels of miR‐144‐3p and miR‐451a were significantly higher in NET‐G1 with LVI versus without LVI, as determined by miRNA array analysis and RT‐qPCR. A significant correlation was observed between miR‐144‐3p and miR‐451a expression levels, strongly suggesting miR144/451 cluster overexpression in NET‐G1 with LVI. Bioinformatic analysis of target genes revealed that miR‐144‐3p and miR‐451a directly interact with PTEN and p19 mRNA, respectively. Immunohistochemistry revealed significantly lower expression of PTEN and p19 in NET‐G1 tissues with LVI than in those without LVI. The miR‐144‐3p and miR‐451a mimic significantly increased cell migration/invasion capability, respectively. Knockdown of PTEN and p19 induced significant augmentation of cell invasion and migration capability, respectively.ConclusionsOur data suggest that overexpression of miR‐144/miR‐451 cluster promotes LVI via repression of PTEN and p19 in rectal NET‐G1 cells. miR‐144/451 cluster may be a novel biomarker for predicting invasion/metastasis in rectal NET‐G1.
Comparison of safety and short‐term outcomes between endoscopic and laparoscopic resections of gastric gastrointestinal stromal tumors with a diameter of 2–5 cm
Authors: Liu Yan‐Bo , Liu Xin‐Yang , Fang Yong , Chen Tian‐Yin , Hu Jian‐Wei , Chen Wei‐Feng , Li Quan‐Lin , Cai Ming‐Yan , Qin Wen‐Zheng , Xu Xiao‐Yue , Wu Linfeng , Zhang Yi‐Qun , Zhou Ping‐Hong 
Published: March 2022

AbstractBackground and AimDevelopments of endoscopic techniques brought the possibility of endoscopic resection for gastrointestinal stromal tumors (GISTs) of larger sizes. We aim to compare safety and short‐term outcomes between endoscopic and laparoscopic resections of gastric GISTs with a diameter of 2–5 cm.MethodsThis is a single‐center, retrospective cohort study. The clinical data, perioperative conditions, and the adverse events of patients who underwent endoscopic or laparoscopic resection for gastric GIST of 2–5 cm in Zhongshan Hospital, Fudan University, from January 2016 to December 2020 were retrospectively reviewed.ResultsA total of 346 patients were reviewed; 12 patients who failed to accomplish the planned procedure were excluded; 182 underwent laparoscopic resection; and 152 underwent endoscopic resection. Significant differences exist in the tumor size between the laparoscopic group (3.43 ± 0.86 cm) and the endoscopic group (2.78 ± 0.73 cm) (P < 0.01). Compared with laparoscopic resection, endoscopic resection was associated with faster recovery (P < 0.01), shorter hospital stays (P < 0.01), and lower cost (P < 0.01). The incidence of Clavien–Dindo grade II–V adverse events in the endoscopic group (3/152) was significantly lower than that in the laparoscopic group (12/182) (P = 0.04). After a propensity score matching analysis, the endoscopic group showed similar incidences of complications with the laparoscopic group, while the advantages over laparoscopic resection in postoperative hospital stay, time to first oral intake, and hospitalization expenses remained significant (P < 0.01).ConclusionsEndoscopic resection is a safe and cost‐effective method for 2–5 cm of gastric GISTs compared with laparoscopic resection.
Implementation of a telehealth videoconference to improve hospital‐to‐skilled nursing care transitions: Preliminary data
Authors: Bellantoni Julia , Clark Elspeth , Wilson Jonathan , Pendergast Jane , Pavon Juliessa M. , White Heidi K. , Malone Deanna , Knechtle William , Jolly Graham Aubrey 
Published: March 2022

AbstractBackgroundTransition‐related patient safety errors are high among patients discharged from hospitals to skilled nursing facilities (SNFs), and interventions are needed to improve communication between hospitals and SNF providers. Our objective was to describe the implementation of a pilot telehealth videoconference program modeled after Extension for Community Health Outcomes‐Care Transitions and examine patient safety errors and readmissions.MethodsA multidisciplinary telehealth videoconference program was implemented at two academic hospitals for patients discharged to participating SNFs. Process measures, patient safety errors, and hospital readmissions were evaluated retrospectively for patients discussed at weekly conferences between July 2019–January 2020. Results were mapped to the constructs of the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE‐AIM) model. Descriptive statistics were reported for the conference process measures, patient and index hospitalization characteristics, and patient safety errors. The primary clinical outcome was all‐cause 30‐day readmissions. An intention‐to‐treat (ITT) analysis was conducted using logistic regression models fit to compare the probability of 30‐day hospital readmission in patients discharged to participating SNFs across 7 months prior to after telehealth project implementation.ResultsThere were 263 patients (67% of eligible patients) discussed during 26 telehealth videoconferences. Mean discussion time per patient was 7.7 min and median prep time per patient was 24.2 min for the hospital pharmacist and 10.3 min for the hospital clinician. A total of 327 patient safety errors were uncovered, mostly related to communication (54%) and medications (43%). Differences in slopes (program period vs. pre‐implementation) of the probability of readmission across the two time periods were not statistically significant (OR 0.95, [95% CI 0.75, 1.19]).ConclusionsA pilot care innovations telehealth videoconference between hospital‐based and SNF provider teams was successfully implemented within a large health system and enhanced care transitions by optimizing error‐prone transitions. Future work is needed to understand process flow within nursing homes and its impact on clinical outcomes.
Regional analysis of aluminum and steel flows into the American automotive industry
Authors: Hua Nate P. , Kelly Jarod C. , Lewis Geoffrey M. , Keoleian Gregory A. 
Published: March 2022

AbstractAluminum and steel represent the two most dominant metals in light‐duty vehicles, yet the flows of these materials into the American automotive industry have not been well characterized. This study proposes and implements a method for analyzing the flow of these metals into the automotive industry. We create a framework for performing regionally linked, sector‐specific material flow analyses and use this framework to trace flows of aluminum and steel entering the American automotive industry, focusing on flows downstream from raw material production. We show that automotive aluminum sheet and extrusions are sourced primarily from the NPCC (23%), SERC (20%), MRO (18%), and RFC (13%) North American Electric Reliability Corporation (NERC) regions, and a spatially unresolved local region within the United States and Canada (18%). We determine that primary aluminum is largely from Canada (70%), nearly all from Quebec (69%). Further upstream, alumina and bauxite originate mostly from Brazil, Australia, and Jamaica. We also show that finished automotive steel is sourced primarily from the RFC (63%) and SERC (20%) regions. The crude steel supply similarly originates mainly from the RFC (69%) and SERC (7%) regions. Upstream raw materials including coke, coking coal, iron ore, lime, and steel scrap are primarily sourced from the United States with only direct reduced iron and pig iron used in electric arc furnace steel production coming mostly from outside the United States. The framework developed here allows for increased spatial resolution of material flows, which can be used to develop more specific life cycle impact factors for life cycle assessments.
Path model on decision‐making ability of clinical nurses
Authors: Park Minsook , Gu Minkyung , Sok Sohyune 
Published: March 2022

AbstractAims and objectivesTo identify and examine the relationship between the factors influencing the decision‐making ability of clinical nurses in hospitals, South Korea, and to establish a model, to verify the fit and the effect.BackgroundClinical nurses are exposed to environments and situations where they make continuous decisions according to the need of direct treatment and nursing.DesignThis study used a cross‐sectional descriptive design, relation prediction modelling and adheres to the STROBE guidelines.MethodsThe model construction was based on the information processing theory by Hansen and Thomas (Nursing Research, 17, 436, 1968). The model consists of 5 exogenous variables (expertise, critical thinking disposition, knowledge‐sharing behaviour, nursing work environment, and decision‐making stress) and 3 endogenous variables (analytic‐systematic decision‐making type, intuitive‐interpretive decision‐making type and decision‐making ability). Participants were 274 clinical nurses, who were working at two hospitals in Seoul, South Korea. The data was analysed using SPSS WIN 18.0 and AMOS 20.0 program. Path analysis to verify the hypothetical model was used, and the fit was evaluated byχ2/df, GFI, AGFI, NFI, CFI and RMSEA. Data were collected from March to May 2017.ResultsThe fit index of the modified path model wasχ2/df= 2.25, GFI = .972, AGFI = .929, NFI = .967, CFI = .981 and RMSEA = .068. The analytic‐systematic decision‐making type had the greatest direct effect on the clinical nurses’ decision‐making ability, which is the final outcome variable, followed by significant direct and indirect effects on critical thinking disposition.ConclusionThis study suggests that the clinical nurses’ decision‐making ability in hospitals were leadingly influenced by analytic‐systematic decision‐making type and critical thinking disposition.Relevance to clinical practiceIn the nursing practice, nurses need to pay attention the analytic‐systematic decision‐making type and critical thinking disposition for improving decision‐making ability of clinical nurses in hospitals.