bluuebunny/crossref_metadata_2025_split huggingface dataset:
Terrestrial records of deglaciation events during terminations V and IV in the central Apennines (Italy) and insights on deglacial mechanisms
Authors: Marra F. , Pereira A. , Jicha B. , Nomade S. , Biddittu I. , Florindo F. , Muttoni G. , Niespolo E. M. , Renne P. R. , Scao V. 
Published: November 2022

Abstract40Ar/39Ar geochronology constraints to aggradational phases and grain size variations show that the two large gravel beds occurring in the sedimentary filling of the Liri fluvial-lacustrine basin (central Italy) recorded the occurrence of deglaciation events synchronous within uncertainties with global meltwater pulses at ca. 450 and 350 ka. In particular, we find a precise match between the ages of gravel deposition and the occurrence of moderate sea-level rise events which anticipate those more marked during the glacial termination V and IV in the Red Sea relative sea level curve, as already verified by data from the Tiber River catchment basin. Such correspondence suggests that gravel deposition is facilitated by melting of Apennine mountain range glaciers, which provide the water transport energy and a surplus of clastic input to the rivers draining the mountain regions and flowing into the Tyrrhenian Sea. Therefore, the thick gravel beds intercalated in the sedimentary filling of the catchment basins of the major rivers in central Italy may be regarded as an equivalent proxy of large deglaciation events, similar to the ice-rafted debris in northern Atlantic. Consistent with this hypothesis, we also show the close correspondence between the occurrence of particularly mild (warmer) minima of the mean summer insolation at 65° N and these early aggradational phases, as well as with other anomalous early sea-level rises occurring c. 750 ka and 540 ka at the onset of glacial termination VIII and VI, and 40 ka at the onset of the so-called Heinrich events.
Spectroscopic characterization and in vitro studies of biological activity of bradykinin derivatives
Authors: Proniewicz Edyta , Burnat Grzegorz , Domin Helena , Iłowska Emilia , Roman Adam , Prahl Adam 
Published: November 2022

AbstractEleven multiple analogs of bradykinin—a peptide that is a natural ligand of B1 and B2 receptors but does not bind or activate the B1 receptor unless Arg9 is removed from the sequence by the action of carboxypeptidase N—were synthesized. Their biological activity was examined on T-REx cell lines expressing B1 or B2 receptors using the intracellular IP1 assay. The mRNA expression of B1R and B2R in the lysate of tumor cell lines, e.g., U87-MG (human astrocytoma), SHP-77 (human small cell lung cancer), and H4 (human brain glioma), was determined. For five B1R antagonists, adsorption at the liquid/solid interface (Au nanoparticles (AuNPs) served as the solid surface) was discussed in terms of the vibrations of molecular fragments (structural factors) responsible for the biological properties of these analogs.
Trace minerals source in calf starters interacts with birth weights to affect growth performance
Authors: Mousavi-Haghshenas M. A. , Hashemzadeh F. , Ghorbani G. R. , Ghasemi E. , Rafiee H. , Ghaffari M. H. 
Published: November 2022

AbstractThe present study was conducted to investigate the effects of partial replacement of inorganic minerals (IM) with trace minerals in advance chelate components form in starter diets for calves of different birth weights on performance, health, and behavior of Holstein calves. Fifty-two calves were assigned to 1 of 4 treatments in a 2 × 2 factorial arrangement with two mineral sources (IM or advanced chelated minerals (ACMS)) and two birth weights (low or normal birth weight; LBW or NBW). Calves were weaned on d 56 and remained until d 71 of the study. Results showed that NBW calves had higher feed intake, withers and hip height, larger heart girth and lower fecal score than LBW calves throughout the study. Calves receiving ACMS tended to have higher feed intake, larger hip width, lower eye and nose scores, and lower rectal temperature throughout the study than IM calves. In addition, ACMS calves had larger abdominal girths at d 56 of the study compared to IM calves. Interactions between birth weights and mineral sources for preweaning average daily gain (ADG) and weaning and final BW showed that ACMS supplementation improved ADG and BW in LBW calves. Non-nutritive oral behavior was lower in ACMS calves compared to IM calves during all periods. Overall, ACMS feeding decreased non-nutritive oral behavior and improved calf health status during the study. In addition, feeding ACMS to dairy calves with LBW increased their ADG to a similar extent as to NBW calves, suggesting an improvement in their efficiency.
Highly efficient ultra-broad beam silicon nanophotonic antenna based on near-field phase engineering
Authors: Khajavi Shahrzad , Melati Daniele , Cheben Pavel , Schmid Jens H. , Ramos Carlos A. Alonso , Ye Winnie N. 
Published: November 2022

AbstractOptical antennas are a fundamental element in optical phased arrays (OPA) and free-space optical interconnects. An outstanding challenge in optical antenna design lies in achieving high radiation efficiency, ultra-compact footprint and broad radiation angle simultaneously, as required for dense 2D OPAs with a broad steering range. Here, we demonstrate a fundamentally new concept of a nanophotonic antenna based on near-field phase-engineering. By introducing a specific near-field phase factor in the Fraunhofer transformation, the far-field beam is widened beyond the diffraction limit for a given aperture size. We use transversally interleaved subwavelength grating nanostructures to control the near-field phase. A Bragg reflector is used at the end of the grating to increase both the efficiency and the far-field beam width. The antenna has a compact footprint of 3.1 µm × 1.75 µm and an ultra-broad far-field beam width of 52° and 62° in the longitudinal and transversal direction, respectively, while the radiation efficiency reaches 82% after incorporating a bottom reflector to further improve the directionality. This unprecedented design performance is achieved with a single-etch grating nanostructure in a 300-nm SOI platform.
Exercise preconditioning improves electrocardiographic signs of myocardial ischemic/hypoxic injury and malignant arrhythmias occurring after exhaustive exercise in rats
Authors: Guo Yuan-Pan , Pan Shan-Shan 
Published: November 2022

AbstractExercise preconditioning (EP) has a good myocardial protective effect. This study explored whether EP improves electrocardiographic (ECG) signs of myocardial ischemic/hypoxic injury and the occurrence of malignant arrhythmia after exhaustive exercise. A total of 120 male SD rats were randomly divided into the control group (group C), early exercise preconditioning group (group EEP), late exercise preconditioning group (group LEP), exhaustive exercise group (group EE), early exercise preconditioning + exhaustive exercise group (group EEP + EE) and late exercise preconditioning + exhaustive exercise group (group LEP + EE). Changes in heart rate (HR), ST segment, T wave and QT corrected (QTc) intervals on ECG; hematoxylin-basic fuchsin-picric acid (HBFP) staining; and cTnI levels were used to study myocardial injury and the protective effect of EP. Compared with those in group C, the levels of plasma markers of myocardial injury, HBFP staining and ECG in group EE were significantly increased (P < 0.05). Compared with those in group EE, the levels of plasma markers of myocardial injury, HBFP staining and ECG in group EEP + EE and group LEP + EE were significantly decreased (P < 0.05). The results suggested that EP improved ECG signs of myocardial ischemic/hypoxic injury and malignant arrhythmias that occur after exhaustive exercise. The ST segment and T wave could also serve as indexes for evaluating exhaustive exercise-induced myocardial ischemia/hypoxia.
The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6
Authors: Barnes Jonathan E. , Lund-Andersen Peik K. , Patel Jagdish Suresh , Ytreberg F. Marty 
Published: November 2022

AbstractSARS-CoV-2 is the pathogen responsible for COVID-19 that has claimed over six million lives as of July 2022. The severity of COVID-19 motivates a need to understand how it could evolve to escape potential treatments and to find ways to strengthen existing treatments. Here, we used the molecular modeling methods MD + FoldX and PyRosetta to study the SARS-CoV-2 spike receptor binding domain (S-RBD) bound to two neutralizing antibodies, B38 and CB6 and generated lists of antibody escape and antibody strengthening mutations. Our resulting watchlist contains potential antibody escape mutations against B38/CB6 and consists of 211/186 mutations across 35/22 S-RBD sites. Some of these mutations have been identified in previous studies as being significant in human populations (e.g., N501Y). The list of potential antibody strengthening mutations that are predicted to improve binding of B38/CB6 to S-RBD consists of 116/45 mutations across 29/13 sites. These mutations could be used to improve the therapeutic value of these antibodies.
Organ perfusion during partial REBOA in haemorrhagic shock: dynamic 4D-CT analyses in swine
Authors: Matsumura Yosuke , Higashi Akiko , Izawa Yoshimitsu , Hishikawa Shuji 
Published: November 2022

AbstractResuscitative endovascular balloon occlusion of the aorta (REBOA) increases proximal blood pressure while inducing distal ischemia of visceral organs. The evaluation of distal ischemia severity during REBOA is a prerequisite for safe resuscitation of haemorrhagic shock patients with REBOA. We evaluated changes in blood flow and organ perfusion due to the degree of occlusion using dynamic 4D-computed tomography (CT). We compared the results with those of a previous study on euvolemic status. Delayed enhancement of the inferior vena cava (IVC) without retrograde flow was observed in the 4D-volume rendering images in the high-degree occlusion. The time-density curve (TDC) of the liver parenchyma (liver perfusion) and superior mesenteric vein (SMV) demonstrated a decreased peak density and a delayed peak in high-degree occlusion. The change rate of the area under the TDC of the liver and SMV decreased linearly as the degree of occlusion increased (PV, Y = −1.071*X + 106.8, r2 = 0.972, P = 0.0003; liver, Y = −1.050*X + 101.8, r2 = 0.933, P = 0.0017; SMV, Y = −0.985*X + 100.3, r2 = 0.952, P = 0.0009). Dynamic 4D-CT revealed less severe IVC congestion during P-REBOA in haemorrhagic shock than in euvolemia. Analyses of TDC of the liver and SMV revealed a linear change in organ perfusion, regardless of intravascular volume.
The effect of work area on work alienation among China’s grassroots judicial administrators
Authors: Liu Nian , Zhang Meiling , Feng Boya 
Published: November 2022

AbstractWork alienation refers to mental self-separation from work, and it is an integral reflection of workers and their work. Few studies have explored the association between work area and work alienation among grassroots judicial administrators. A stratified sampling method was used to collect data from 288 grassroots judicial administrators in Guangzhou to measure the overall status quo and work alienation in this group. This study found that the current grassroots judicial administrative team has a reasonable structure, high professional quality, and rich grassroots work experience, but a high level of work intensity (Mean = .667) and a lack of autonomy (Mean = .757) are prominent. Work area (unstandardized regression coefficient, B = .917) is significantly related to work alienation when controlling for sociodemographic and work characteristic variables: the closer the work area is to the city centre areas, the higher the level of work alienation. In addition, education level also has a significant effect on work alienation: the lower the individual education level is, the stronger the work alienation. The discussion focuses on the knowledge needs in grassroots judicial administrative work and the importance of the external working environment, and further research implications are proposed.
Instant quantification of sugars in milk tablets using near-infrared spectroscopy and chemometric tools
Authors: Thanavanich Chanat , Phuangsaijai Nutthatida , Thiraphatchotiphum Chanidapha , Theanjumpol Parichat , Kittiwachana Sila 
Published: November 2022

AbstractMilk tablets are a popular dairy product in many Asian countries. This research aimed to develop an instant and rapid method for determining sucrose and lactose contents in milk tablets using near-infrared (NIR) spectroscopy. For the quantitative analysis, a training set composed of laboratory-scale milk samples was generated based on a central composite design (CCD) and used to establish partial least squares (PLS) regression for the predictions of sucrose and lactose contents resulting in R2 values of 0.9749 and 0.9987 with the corresponding root mean square error of calibration (RMSEC) values of 1.69 and 0.35. However, the physical difference between the laboratory-scale powder and the final product milk tablet samples resulted in spectral deviations that dramatically affected the predictive performance of the PLS models. Therefore, calibration transfer methods called direct standardization (DS) and piecewise direct standardization (PDS) were used to adjust the NIR spectra from the real milk tablet samples before the quantitative prediction. Using high-performance liquid chromatography (HPLC) as a reference method, the developed NIR-chemometric model could be used to instantly predict the sugar contents in real milk tablets by producing root mean square error of prediction (RMSEP) values for sucrose and lactose of 5.04 and 4.22 with Q2 values of 0.7973 and 0.9411, respectively, after the PDS transformation.
Sleep quality of patients with papillary thyroid carcinoma: a prospective longitudinal study with 5-year follow-up
Authors: Koo Dae Lim , Park Yangmi , Nam Hyunwoo , Chai Young Jun 
Published: November 2022

AbstractWe evaluated the pre- and postoperative sleep quality of patients with newly diagnosed papillary thyroid carcinoma (PTC) who underwent thyroid surgery, and investigated the factors associated with persistent poor sleep quality. The Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale, and Stanford sleepiness scale were used to estimate sleep quality and daytime sleepiness. Face-to-face surveys were conducted preoperatively, and 1, 4, and 10 months after thyroid surgery. The PSQI was administered during a telephone interview about after 5 years after surgery. Forty-six patients (mean age 47.3 ± 10.1 years) with PTC (11 males, 35 females) were included in this study. Twenty-one participants underwent lobectomy and 25 underwent total thyroidectomy. Preoperatively, 35 (76.1%) patients showed poor sleep quality. PSQI scores at postoperative 1, 4, and 10 months were significantly lower than preoperative scores (p < 0.001). Postoperative 5-year PSQI scores decreased significantly compared to the preoperative scores (p < 0.001). Patients newly diagnosed with PTC suffered from sleep disturbance before and after surgery for at least 10 months, recovering to a comparable rate of sleep disturbance with the general population by 5 years after surgery. Higher preoperative PSQI score was at risk for prolonged poor sleep quality in patients with PTC.
RETRACTED ARTICLE: Second-order convergence analysis for Hall effect and electromagnetic force on ternary nanofluid flowing via rotating disk
Authors: Shahzad Faisal , Jamshed Wasim , El Din Sayed M. , Shamshuddin Md. , Ibrahim Rabha W. , Raizah Zehba , Adnan  
Published: November 2022

AbstractThe purpose of this research was to estimate the thermal characteristics of tri-HNFs by investigating the impacts of ternary nanoparticles on heat transfer (HT) and fluid flow. The employment of flow-describing equations in the presence of thermal radiation, heat dissipation, and Hall current has been examined. Aluminum oxide (Al2O3), copper oxide (CuO), silver (Ag), and water (H2O) nanomolecules make up the ternary HNFs under study. The physical situation was modelled using boundary layer analysis, which generates partial differential equations for a variety of essential physical factors (PDEs). Assuming that a spinning disk is what causes the flow; the rheology of the flow is enlarged and calculated in a rotating frame. Before determining the solution, the produced PDEs were transformed into matching ODEs using the second order convergent technique (SOCT) also known as Keller Box method. Due to an increase in the implicated influencing elements, several significant physical effects have been observed and documented. For resembling the resolution of nonlinear system issues come across in rolling fluid and other computational physics fields.
A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors
Authors: Li Ruiqi , Mei Shuchong , Ding Qiang , Wang Qingming , Yu Li , Zi Fuming 
Published: November 2022

AbstractMore and more evidence show that HK2 is closely related to tumors. But no pan-cancer analysis is available. This paper aimed to explore the potential roles of HK2 across thirty-three tumors based on the datasets of the cancer genome Atlas (TCGA) and gene expression omnibus. HK2 is highly expressed in most tumors and related to the progression of some tumors. HK2 expression was associated with the infiltration of T follicular helper cells for the TCGA tumors of uveal melanoma, breast invasive carcinoma (BRCA), breast invasive carcinoma-luminalA (BRCA-LumA), head and neck squamous cell carcinoma (HNSC), head and neck squamous cell carcinoma with HPV positive (HNSC-HPV+), and cancer-associated fibroblasts for the tumors of brain lower grade glioma and stomach adenocarcinoma. Our first pan-cancer study offers a relatively comprehensive understanding of the roles of HK2 in different tumors.
Screening and health education practices related to cardiovascular risk factors among adults: results of a households survey in Sousse, Tunisia
Authors: Zammit Nawel , Belgacem Waad Ben , Ghammam Rim , Fredj Sihem Ben , Krifa Rim , Ouertani Mohamed , Maatouk Amani , Maatoug Jihene , Ghannem Hassen 
Published: November 2022

AbstractIn Tunisia, despite the implementation of national strategies to prevent some of cardiovascular risk factors, these diseases still represent the leading cause of death. The current study aimed to determine the prevalence of cardiovascular risk factors and assess the screening and health education practices related to these factors among the adults of Sousse (Tunisia). A cross-sectional study was conducted in 1000 households in Sousse, Tunisia. To collect data, a team of trained medical doctors administered by interview a pre-tested questionnaire and performed blood pressure and anthropometric measures at the participants’ homes. In total, 1977 adults participated in the study. Their mean age was 39.8 (± 13.8) years. The Females/Males sex ratio was 1.5. Weight excess and lack of physical activity were found in 65.4% and 60.7% of participants. Screening for obesity and android obesity were reported by 36.6% and 5.7% of health services users. Advices from a healthcare professional to practice the recommended physical activity and eat healthily were reported by less than a third of these latter. Screening and health education practices related to cardiovascular risk factors should be reinforced in the Tunisian healthcare facilities. The implementation of multisectoral actions is necessary at the national level in order to obtain an environment that promotes a healthy lifestyle.
Maternal and child FUT2 and FUT3 status demonstrate relationship with gut health, body composition and growth of children in Bangladesh
Authors: Gazi Md. Amran , Fahim Shah Mohammad , Hasan Md. Mehedi , Hossaini Farzana , Alam Md. Ashraful , Hossain Md. Shabab , Hossain Md. Daluwar , Das Subhasish , Haque Rashidul , Mahfuz Mustafa , Ahmed Tahmeed 
Published: November 2022

AbstractFucosyltransferase 2 (FUT2) and 3 (FUT3) may influence host biological functions. We aim to assess the relationship between maternal and child FUT2 (Secretor) and FUT3 (Lewis) status with growth, body composition, gut health and histologic features in Bangladeshi children. We conducted a case–control study where secretor and Lewis status were ascertained from saliva samples of 408 mother–child dyads. Upper-arm fat area estimate (UFE) and total upper arm area (TUA) were found higher among children of Lewis negative mothers (p = 0.01 and p = 0.07, respectively). Changes in UFE after nutrition intervention were significantly greater among Lewis positive children than those of negative for Lewis (p = 0.05). Significant differences were observed for child UFE based on secretor and Lewis status of the mothers (p = 0.04). Lewis positive children had greater changes in WAZ (p = 0.07) and WLZ (p = 0.02) than Lewis negative children at the end of nutrition intervention. Fecal Reg1B was elevated in secretor positive children compared to their counterparts (p = 0.03). Lewis negative children had higher concentrations of MPO compared to Lewis positive children (p = 0.08). We also observed a higher frequency of subtotal villous atrophy among secretor negative and Lewis positive children (p = 0.09 and p = 0.01, respectively) than those of their counterparts. The findings provide insights for further studies to elucidate causal influences.
Infrared nanospectroscopic imaging of DNA molecules on mica surface
Authors: Custovic Irma , Pocholle Nicolas , Bourillot Eric , Lesniewska Eric , Piétrement Olivier 
Published: November 2022

AbstractSignificant efforts have been done in last two decades to develop nanoscale spectroscopy techniques owning to their great potential for single-molecule structural detection and in addition, to resolve open questions in heterogeneous biological systems, such as protein–DNA complexes. Applying IR-AFM technique has become a powerful leverage for obtaining simultaneous absorption spectra with a nanoscale spatial resolution for studied proteins, however the AFM-IR investigation of DNA molecules on surface, as a benchmark for a nucleoprotein complexes nanocharacterization, has remained elusive. Herein, we demonstrate methodological approach for acquisition of AFM-IR mapping modalities with corresponding absorption spectra based on two different DNA deposition protocols on spermidine and Ni2+ pretreated mica surface. The nanoscale IR absorbance of distinctly formed DNA morphologies on mica are demonstrated through series of AFM-IR absorption maps with corresponding IR spectrum. Our results thus demonstrate the sensitivity of AFM-IR nanospectroscopy for a nucleic acid research with an open potential to be employed in further investigation of nucleoprotein complexes.