bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefits of High-Dose Vitamin C in Patients with Sepsis
Authors: Mahen Mawin , Hasan Nabila , Maria Suzy 
Published: November 2022

In sepsis, there is an increase in oxidative stress which plays important role in further physiological derangement. Due to its potent antioxidant effect, vitamin C has been proposed as a potential adjunct treatment in patients with sepsis. This study aims to evaluate the benefits of vitamin C administration in patients with sepsis. A systematic search was conducted using electronic databases PubMed, Scopus, ProQuest, and Cochrane with keywords combination of vitamin C/ascorbic acid and sepsis/septic. The limits of the search included English language, human subjects, and adults. To limit the confounding effect, only studies with vitamin C monotherapy were considered for inclusion. Seven relevant studies comprising five clinical trials and two retrospective studies were included in this paper for critical appraisal. Most studies found some clinical benefits with the use of vitamin C in patients with sepsis compared to placebo, such as a reduction in SOFA score and mortality. However, these favourable outcomes were not consistent in all studies. In conclusion, vitamin C is a promising adjunct treatment option in patients with sepsis, however further large, optimized multicenter trials are needed to definitively confirm its benefits.
Keywords: vitamin C, ascorbic acid, sepsis, septic shock.

Manfaat Vitamin C Dosis Tinggi untuk Pasien Sepsis
Abstrak
Kondisi sepsis menyebabkan peningkatan stres oksidatif yang berperan penting dalam menyebabkan gangguan fisiologis lebih lanjut. Karena memiliki efek antioksidan yang kuat, vitamin C telah diusulkan sebagai terapi adjuvan yang menjanjikan pada pasien sepsis. Penelitian ini bertujuan untuk mengevaluasi manfaat pemberian vitamin C pada pasien sepsis. Pencarian sistematis dilakukan menggunakan database elektronik PubMed, Scopus, ProQuest, dan Cochrane dengan kombinasi kata kunci vitamin C/asam askorbat dan sepsis/ septik. Batas pencarian yaitu bahasa Inggris, subjek manusia, dan usia dewasa. Untuk membatasi efek perancu, hanya studi yang menggunakan monoterapi vitamin C yang dipertimbangkan untuk dimasukkan. Tujuh studi relevan yang terdiri dari lima uji klinis dan dua studi retrospektif dimasukkan dalam tulisan ini untuk telaah kritis. Sebagian besar studi mendapatkan manfaat klinis penggunaan vitamin C pada pasien sepsis dibandingkan dengan plasebo, misalnya penurunan skor SOFA dan angka mortalitas, namun hasil positif ini tidak konsisten dalam semua penelitian. Sebagai kesimpulan, vitamin C adalah pilihan terapi adjuvan yang menjanjikan pada pasien sepsis, namun butuh penelitian multisenter yang lebih besar dan optimal untuk memastikan manfaatnya secara definitif.
Kata kunci: vitamin C, asam askorbat, sepsis, syok sepsis
Interaction Analysis in Nurseries
Authors: Klein Ágnes , Tancz Tünde 
Published: November 2022

Abstract

Introduction:
The present research aimed to review the qualitative aspects of communication between children and their caregivers. We focused on the presence of quality indicators, on the strategies we encounter in influencing language acquisition in the interaction between children and early childhood educators.

Methods:
We examined the diversity, awareness and efficiency with which educators use communication tools and techniques in various preschool education situations for children under 3 years of age. In the empirical survey of day-care interactions a questionnaire was based on the evaluation and observation of questionnaire responses.

Results:
The emotional and motivational basis of language acquisition is formed by the toddler’s social inclinations and attachment needs, as well as social inclinations, with his environment playing a prominent role in changing these processes.

Discussion:
These interactions provide a framework for language acquisition, where in the classic case language acquisition is not guided, but takes place through everyday situations, through participation in authentic communication situations. The axiom is that language skills develop in language use.

Limitations:
The questionnaire was validly completed by 60 people. The data collection concentrated on the region of southern and northern Transdanubia in Hungary. Although not in national terms, this offers the opportunity to evaluate and reflect on the situation at the regional level.

Conclusions:
The professional communication and competent language development activity of educators’ results from the interplay of scientific-theoretical knowledge, implicit empirical knowledge, competence-oriented procedures
Phenotypic diversity and path analysis of seed yield in Bambara groundnut grown in rain forest agroecological zone
Authors: Adeniji Olawale Taiwo , Adekoya Modinat , Olosunde Busayo , Ekanem Ukobong , Iseghohi Innocent , Badmus Adenike 
Published: November 2022

Abstract
Bambara groundnut is a reliable source of carbohydrates and protein in rainforest agroecology, but limited research had been done and few varieties commercialised. The magnitude of phenotypic variability, character association, and contribution of characters to seed yield were investigated among 50 accessions received from IITA, Nigeria. Field evaluation took place during the 2017 – 18 cropping seasons. The accessions were allocated to experimental plots using a Randomised Complete Block Design with three replicates. Data were collected on phenological, agronomic, and seed yield characters. The main effect showed significant (p ≤ 0.05) differences for phenological, vegetative, and reproductive characters. The year effect influenced agronomic and seed yield characters while accessions by year interaction were insignificant for all characters. The stepwise discriminant analysis identified three redundant characters. The leaflet length and width, canopy spread, leaf/plant, seeds/plant, and seed weight showed high discriminatory ability and are efficient for morphological characterisation and conservation. Hybridisation between accessions dispersed in quadrants 1, 2, and 4 may evolve early and medium maturity types with improved seed yield and biomass. The number of seeds/plant and pods/plant are indices for seed yield. The contribution of pods/plant to seed yield was masked by canopy spread, peduncle length, and pod width indicating competition for photo-assimilates. TVSu 17, TVSu 277, TVSu 271, and TVSu 278 are donor parents for earliness. TVSu 261 performed best for seed yield and yield component characters. Hybridisation among TVSu 261, TVSu 587, TVSu 275, and TVSu 17 will evolve medium maturing and high seed-yielding varieties for further evaluation.
Civic Education for Sustainable Development of UNESCO – Decade 2005–2014
Authors: Brunold Andreas , Ohlmeier Bernhard 
Published: November 2022

Abstract
The aim of the research and investigation methodology was based on an expert survey, using questionnaires translated into German, English, French, Spanish and Portuguese languages. The experts, interviewed in this study as part of the international community, represent institutions or organizations, that are involved in educational policy or in university research and teaching contexts with the topics and content as well as the implementation of ESD. The answers of the experts provide a different and wide range of variations in assessments of the implementation of the UN Decade and its characteristics of democratic potential and support. This shows that the potential democratic influences can always be assessed much more positively through sustainable development than that of actual democratic changes, particularly in reference to good governance, to the basic and human rights, to the protection of minorities, to civil society participation and to the separation of powers and the rule of law.
How Can I Maintain my Own Identity Within a Crowd? Suggestions From Totalitarian Experiences
Authors: Franzenburg Geert 
Published: November 2022

Abstract
How can the individual preserve his identity within a crowd? How can he/she counter the threats and the temptations of the mass phenomenon? In the following, these questions are answered, correctly based on two contrasting and complementary situations and approaches: on the one hand, the beginnings of the Soviet Union in the 1920s as manifested in everyday life in Moscow (journalistic-systemic view). On the other hand, on biographies of NSDAP members in Germany in the 1920s (biographical approach). The theoretical background provides philosophical treatises from this period (Elias Canetti, José Ortega y Gasset, and Karl Jaspers). Because the situations characterize starting points of totalitarian system (Sowjet-Union/Nazi-Regime), they allow transformations into current and future experiences of collective and group pressure in private and business life, where people experience similar challenges and temptations that are more elementary.
“I believe in video!” An Interpretative Phenomenological Analysis of Video as an Educational Resource
Authors: Østereng Dag Øivind 
Published: November 2022

Abstract
Elevkanalen is a web-based digital educational resource containing videos, animations, pictures, learning paths, texts, quizzes, and many features that meet the Norwegian authorities’ requirements for adapted and inclusive learning issued by The Norwegian Directorate for Education and Training (UDIR). The interest of this paper is to examine how the editors of Elevkanalen comprehend video as an educational resource and accordingly contribute to a discussion of professional assessment and didactical utilisation of video in teaching and learning. The protagonists of video-based learning are generally not reluctant to advocate the benefits of using video in education. Nevertheless, in order to be beneficial, it is reasonable to suppose that a deliberate and professional didactical utilisation is required. Video-based learning is at the centre of this study, and the ICAP theory is applied to critically assess video as a learning resource. Moreover, this is discussed in relation to perspectives on education for sustainable development
The Overly Sensitive Nature of Aged Family Inmates as a Socio-Cultural Barrier to Combat Covid-19
Authors: Javed Muniza , Fatima Fizza 
Published: November 2022

Abstract
Human history is full of evidence showing a larger number of human and animal populations got affected by infectious diseases, viruses, and bacteria. Like previous life-threatening pandemics, coronavirus appeared to be a deadly virus in 2019 and declared as pandemic in 2020 by WHO. As per Global Reports, senior citizens have been most vulnerable to the corona virus attacks. This paper explores the experiences of family members dealing with elderly at home in the midst of the Covid-19 outbreak and how they managed them keeping in view their mindset on disease and socio-cultural constraints. For this purpose, qualitative research methods were adopted. 20 participants were selected for the in-depth interviews through purposive sampling. Following themes generated as a result of the data analysis: stubborn and rigid behavior of elderly, emotionally complex reactions, socio-cultural barriers, and traditional approach to the disease. Findings depicted the most common social cultural barriers in dealing with the difficult nature of elderly people are family ties, religious norms, respect, and empathy towards elderly people. Further, research findings highlighted major sentiments of older adults comprise attachment towards their grandchildren, feeling of insecurity, feeling of getting stigmatized, considering themselves as a virus spreader and feeling of being left out. It was found that older adults felt stigmatized, lonely, left out and considered SOPs (Standard Operating Procedures) as imposed remedial steps. Overall, it was found that at older age people express more anxiety and fear towards loneliness. Findings will help in sensitizing policy makers to design awareness sessions, religious and other home-based social activities for elderly people to combat stress related to loneliness in older age.
Graph based anomaly detection in human action video sequence
Authors: Kavimandan Pranoti Shrikant , Kapoor Rajiv , Yadav Kalpana 
Published: November 2022

Abstract
In our paper, we have proposed to use graphs to detect anomaly in human action video. Although the detection of anomaly is a widely researched topic, but very few researchers have detected anomaly in action video using graphs. in our proposed method we have represented the smaller section (sub-section) of our input video as a graph where vertices of the graph are the space time interest points in the sub-section video and the association between the space time interest points exists. Thus, graphs for each sub section are created to look for a repeated substructure. We believe most of the actions inherently are repeated in nature. Thus, we have tried to capture the repetitive sub-structure of the action represented as a graph and used this repetitive sub-structure to compress the graph. If the compressed graph has few elements that have not been compressed, we suspect them as anomaly. But the threshold value takes care not to make the proposed method very much sensitive towards the few uncompressed elements. Our proposed method has been implemented on locally created “extended KTH” and “extended Weizmann” datasets with good accuracy score. The proposed method can also be extended for few more applications such as training athletes and taking elderly care.
Some Practical Aspects of Thinking and Decision Making
Authors: Rehman Sharaf N. 
Published: November 2022

Abstract
This paper explores the relationship between thinking and decision-making. In the first part, the paper analyzes the process of thinking from three aspects – language, psychology, and behavior. It then proceeds to investigate the implications of different kinds of thinking ondecision-making. The final section of the paper raises some questions and concerns about the role of the scientific method in making decisions under conditions of uncertainty. The author offers specific examples from the book publishing business and the movie industry.
Treatment of diabetic ketoacidosis with subcutaneous regular insulin in a non-ICU setting is effective and economical: A single-center experience
Authors: Ayyavoo Ahila , Ravikulan Abhimati , Palany Raghupathy 
Published: November 2022

Background:
The mainstay of treatment for diabetic ketoacidosis (DKA) is the correction of dehydration and hyperglycemia with intravenous fluids and intravenous insulin (IVI). Subcutaneous insulin (SCI) has been tried in a few centers in patients with DKA if the blood pH is >7. In general, IVI is preferred over SCI or intramuscular insulin as its onset is rapid and the dose can be titrated based on patient’s varying blood glucose (BG) levels. However, IVI is associated with higher cost of hospitalizations and resource requirements. Thus, SCI could be an alternative to IVI infusion for DKA to reduce these costs and distress, in children during times of resource constraint such as the COVID-19 pandemic and in other resource-limited settings.

Objective:
The objective of the study was to compare the cost and efficacy of SCI therapy versus IVI infusion in the treatment of DKA.

Materials and methods:
A retrospective and cohort study was conducted among children aged 1–15 years admitted with DKA from 2013 to 2014 and treated with IVI and in 2017 treated with SCI at a tertiary hospital. One cohort was treated with IV infusion of regular insulin in intensive care units (ICU) and another cohort was treated with SC regular insulin in pediatric general wards. The main outcomes measured were the overall cost of hospitalization and hours to improvement in the child’s health. The data were analyzed with independent samples t-test with SPSS software.

Results:
Forty-eight patients admitted with 50 episodes of DKA were analyzed. Baseline characteristics of the two groups were similar in age, sex, BG, serum sodium, and HbA1C levels. The proportion of girls to boys was 13:8 (IV insulin group) and 20:9 (SC insulin group); the daily dose of insulin on day 1 of treatment was 1.2:1 unit/kg/day in IVI: SCI groups. The lowest recorded pH was 6.822 (range 6.822–7.154) and 6.831(range 6.831–7.292) in the IVI and SCI groups. The mean pH was 7.00 ± 0.10 and 7.1 ± 0.12, respectively, in IVI and SCI groups (P = 0.02). Episodes of DKA treated with IVI and SCI groups were 21 and 29, respectively. 23% of patients had severe DKA, 52% had moderate DKA, and 25% had mild DKA. The mean time for improvement in the IVI group was 34.95 ± 14.05 h and 17.23 ± 9.85 h in the SCI group (P = 0.001), respectively. The average cost of hospitalization was Rs. 53712 ± 18813 for IVI therapy and Rs. 14369 ± 5768 for SCI (P = 0.000). There were no major complications in the SCI group compared to the IVI group.

Conclusion:
DKA was managed effectively in general wards with SCI therapy with pH not being a limiting factor. Earlier studies have used SCI only in patients with a pH of >7. Therapy with SCI was cost-effective and would be useful in resource-poor settings.
STRUCTURAL PECULIARITIES OF DNA-DPS CLUSTERS AT DIFFERENT CONCENTRATIONS OF 4-HEXYLRESORCINOL
Authors: Tereshkina K. , Loiko N. , Tereshkin E. , Kovalenko V. , Generalova A. , Krupyanskii Y. 
Published: November 2022

The formation of complexes and crystals of bacterial nucleoid DNA inside bacterial cells in response to adverse external influences is of great interest both in biophysics and structural biology, and in various fields of industry. The main role in the condensation and crystallization of DNA in bacteria under stressful conditions (starvation, temperature, oxidative, and other types of stress) is played by DNA-binding proteins DPS. In this work, the dynamic behavior and structure of Escherichia coli DPS protein complexes in solution with short-chain DNA (25 base pairs) are studied using classical molecular dynamics in the all-atom approximation with a change in the concentration of the phenolic lipid 4-hexylresorcinol, which is a chemical analog of bacterial anabiosis inducers. The effect of changing the concentration of
4-hexylresorcinol from 0 to 50, 100 and 500 molecules on the DNA-DPS complex is being studied. By searching for the linear interaction energy, data were obtained on the free energies of DNA-protein binding without and in the presence of 4-hexylresorcinol. It has been shown that high concentrations of
4-hexylresorcinol promote the formation of DNA complexes with DPS. To identify the features of the dynamic behavior of DNA and protein, the principal component analysis was carried out. The spatial and energy characteristics of the complexes was obtained.
ANALISIS MANAJEMEN KOMUNIKASI KRISIS PT RAJAWALI NUSANTARA INDONESIA (PERSERO) DALAM MEMPERTAHANKAN CITRA PERUSAHAAN
Authors: Maulida Rizkia Putri 
Published: November 2022

PT Rajawali Nusantara Indonesia (Persero) merupakan Badan Usaha Milik Negara (BUMN) yang bergerak pada bidang Agro Industri yang memiliki 11 anak perusahaan satu diantaranya sedang mengalami krisis, krisis yang terjadi akibat adanya Sengketa Lahan Petani Tebu yang disebabkan oleh faktor oknum yang tidak bertanggung jawab.
Tujuan penelitian ini adalah untuk mengetahui penyelesaian krisis pada kasus Sengketa Lahan Petani Tebu dengan menganalisis Manajemen komunikasi krisis meliputi, faktor penyebab terjadinya krisis, bagaimana upaya penanggulangan krisis, penyelesaian krisis. Teori yang digunakan dalam penelitian ini adalah teori Public Relations issue & Crisis Management dari Kriyantono (2015) dalam bukunya meliputi Pra krisis, Krisis, Pasca krisis, Sumber dan jenis krisis, Strategi Komunikasi Krisis: Begin it at once penelitian ini menggunakan metode Kualitatif dan metode deskriptif dengan teknik pengumpulan data yang dilakukan adalah wawancara, observasi, dan dokumentasi. Wawancara dilakukan melalui zoom meeting dengan satu key informan yaitu executive vice president dan satu informan merupakan Staff Corporate Communications kemuadian menggunakan dua triangulasi sumber, informan tersebut merupakan orang yang terkait dengan permasalahan kasus tersebut dan juga informan lainnya.
Setelah penelitian ini dilaksanakan ada beberapa hasil penelitian menunjukan Manajemen komunikasi krisis tersebut dibagi menjadi 3 tahap yaitu Pra krisis, Krisis, Pasca krisis, Sumber dan jenis krisis. Pada tahapan persiapan atau Pra krisis dilakukannya analisis seputar issue yang berkembang dan untuk memitigasi krisisnya dilakukan mapping pra krisis korporasi hingga mapping Manajemen risiko, salah satu upaya pencegahan dengan dibuatnya program kemitraa, dan termasuk dilakukannya pelatihan krisis komunikasi pada korporasi, selanjutnya tahapan Krisis menerapkan crisis communications kepada RNI pusat, Pemerintah daerah, dan menjalankan media relations. Kemudian pada tahapan Pasca krisis berfokus pada pemulihan citra yang dilakukan dengan menggunakan strategi communications yang melibatkan dengan publikasi positif terkait dengan corporate actions dan CSR korporasi.

Kata kunci : Manajemen komunikasi krisis, Public Relations
Role of Magnetic Resonance Cholangiopancreatography in the Evaluation of Obstructive Jaundice
Authors: Karki S. , Phuyal A. , Poudel R. C. , Bhandari A. , Dahal M. R. 
Published: November 2022

Background Magnetic Resonance Cholangiopancreatography is a reliable and highly sensitive imaging modality in the diagnosis of Obstructive jaundice.
Objective To evaluate the diagnostic accuracy of Magnetic Resonance Cholangiopancreatography as compared to Endoscopic Retrograde Cholangiopancreatography.
Method A prospective, analytical study was conducted in the Department of Radiodiagnosis and Imaging at Dhulikhel Hospital between October 2018 and December 2020. Altogether 100 patients of all ages with obstructive jaundice undergoing Magnetic Resonance Cholangiopancreatography and Endoscopic Retrograde Cholangiopancreatography were included. The causes of obstructive jaundice as identified by Magnetic Resonance Cholangiopancreatography were compared to that of Endoscopic Retrograde Cholangiopancreatography considering Endoscopic Retrograde Cholangiopancreatography as gold standard for the diagnosis.
Result Magnetic Resonance Cholangiopancreatography revealed choledocholithiasis in 60 (60%) patients, benign stricture – 14(14%), malignant stricture-11(11%), periampullary carcinoma in 8(8%) and normal study in 4(4%) patients. Endoscopic Retrograde Cholangiopancreatography showed choledocholithiasis in 59(59%) patients, strictures (benign in 13%, malignant in 10%), ascariasis in 3(3%) and normal findings in 5(5%) patients. The sensitivity, specificity, positive predictive value and negative predictive value of Magnetic Resonance Cholangiopancreatography in detecting choledocholithiasis were 96.6%, 92.3%, 95%, and 95%. The same values for benign strictures were 92.3%, 97.7%, 85.7% and 98.9%, whereas those for malignant strictures were 90.9%, 98.8%, 90.9% and 98.8%. All values were 100% for peri-ampullary carcinoma and ascariasis. Hence, Magnetic Resonance Cholangiopancreatography showed good accuracy for detecting causes of obstructive jaundice (p < 0.05) as compared to Endoscopic Retrograde Cholangiopancreatography.
Conclusion Magnetic Resonance Cholangiopancreatography is an accurate, non-invasive technique in evaluation of obstructive jaundice and offers similar diagnostic value compared to Endoscopic Retrograde Cholangiopancreatography.