bluuebunny/crossref_metadata_2025_split huggingface dataset:
Receptive vocabulary knowledge in L2 learners of Spanish: The role of high‐frequency words
Authors: Robles‐García Pablo 
Published: May 2022

The ChallengeU.S. university students enroll in 2 years of language courses before advancing to linguistics, literature, and culture courses. However, do students have the basic vocabulary needed to transition to advanced courses? This article answers this question by examining 943 L2 Spanish students' knowledge of high‐frequency words at different proficiency levels.
Captive Christmas: Unwrapping the third space
Authors: Munn Melissa , Sanjenko Bethany 
Published: May 2022

AbstractEvery year, millions of people spend Christmas behind bars, yet very little scholarship examines the carceral Christmas. This research attempts to add to the literature by using over 70 years of prisoners’ writings to describe how this holiday season is physically and psychologically experienced by convicts. Drawing on third space scholarship, we argue that prisoners use the manifestations of the holiday season to temporarily ‘escape’ the carceral milieu. More specifically, we contend that the dominant discourses, while not completely refuted, become redefined and reconstituted during the celebratory period. The typical binaries found within the prison (free/captive, inside/outside, keeper/kept), are blurred as a more liminal space emerges. Ultimately, this new imagined space provides a mechanism through which prisoners survive a carceral Christmas.
Rheological, texture and in vitro digestibility properties on steamed rice bread modified by ultrafine grinding and high pressure homogenization on rice‐okara slurry
Authors: Tang Zhongyue , Fan Jin , Yang Jintao , Liu Lu , He Laping , Zhang Wei , Zeng Xuefeng , Qin Likang 
Published: May 2022

SummaryIn this study, the ultrafine grinding (UG) and high pressure homogenization (HPH) treated slurry on the particle size and rheological property of slurry, texture, in vitro starch digestibility, and multiscale structure of steamed rice bread (SRB) were investigated. Then, it was found that the average particle size of slurry treated by UG and HPH reduced from 84.6 to 38.6 μm and 22.6 μm, respectively. The rheological properties results demonstrated that G′ resulted in higher values than G″, and that the values of G′, G″ and tan δ of slurry decreased obviously after UG and HPH treatment. Obviously, the hardness and viscidity of SRB made by UG and HPH were lower, while the elasticity and specific volume were higher. The determination of in vitro starch digestibility revealed that UG treated on slurry accelerated the starch hydrolysis rate of SRB, resulting in an increase in the pGI from 76.17 to 79.36, while HPH treatment reduced the pGI from 76.17 to 73.49. Furthermore, XRD and FTIR demonstrated that both UG and HPH increased the intermolecular hydrogen bonds, and both treatments also assisted in starch arrangement for increasing the ordered crystallization of starch, which may contribute to the increasing amylose content.
Evaluation of the composition and quality of watermelon and mango juices fermented by Levilactobacillus brevis, Lacticaseibacillus casei and Pediococcus pentosaceus and subsequent simulated digestion and storage
Authors: Mandha Juliana , Shumoy Habtu , Matemu Athanasia O. , Raes Katleen 
Published: May 2022

SummaryThis study evaluated the composition of watermelon and mango juices fermented by Levilactobacillus (L.) brevis, Lacticaseibacillus (La.) casei and Pediococcus (P.) pentosaceus and subsequently simulated in vitro digestion and storage (4°C for 35 days). After fermentation (24 h), the microorganisms grew (~9 log CFU mL−1) and fermented watermelon (FWJ) and mango juice (FMJ) became more red and yellow, respectively. DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) and ABTS (2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid)) free radical scavenging capacities significantly increased in L. brevis and La. casei FMJ. After in vitro digestion, all the strains except La. casei in FMJ significantly decreased (P < 0.05), and P. pentosaceus survival was 2.4 and 4.5 times higher in FWJ and FMJ, respectively, than as pure culture. After storage, cell counts remained above 7 log CFU mL−1, and no changes in quality attributes, total phenolic content and antioxidant capacity were recorded in P. pentosaceus FMJ. Thus, watermelon and mango are suitable matrices for lactic acid bacteria.
Risk and protective factors for a salutogenic sense of health in adolescents with Moyamoya disease
Authors: Oh Won‐Oak , Shim Kyu Won , Yeom In‐Sun , Park Il Tae , Heo Yoo Jin , Han Jihee 
Published: May 2022

AbstractPurposeTo identify the risk and protective factors affecting a salutogenic sense of health in adolescents with Moyamoya disease based on Antonovsky's salutogenesis theory.MethodsThis study used a qualitative descriptive design. We interviewed adolescents diagnosed with Moyamoya disease and their parents and experts with experience in treating them from 4 July 2019 to 10 October 2019. Data analysis was performed according to the process of deductive content analysis based on Antonovsky's salutogenesis theory.ResultsThis study identified risk and protective factors affecting a salutogenic sense of health in adolescents with Moyamoya disease. Risk factors were closely related to problems with friends, parent relationships and academic work. Protective factors were identified as emotional support through interpersonal relationships, positive attitudes to the disease situation, ability to understand and predict patterns of symptoms, increasing strength to resolve the state of tension and developing available resources.ConclusionThe factors affecting a salutogenic sense of health in adolescents were identified reflecting on the characteristics of the developmental stage of adolescents and the symptoms and situations that are unique to adolescents. It is important for adolescents with Moyamoya disease to recognize available resources and use them appropriately to successfully manage the state of tension caused by stress.
Association between hyperglycaemia in pregnancy and growth of offspring in early childhood: The PANDORA study
Authors: Titmuss Angela , Longmore Danielle K. , Barzi Federica , Barr Elizabeth L. M. , Webster Vanya , Wood Anna , Simmonds Alison , Brown Alex D. H. , Connors Christine , Boyle Jacqueline A. , Oats Jeremy , McIntyre H. David , Shaw Jonathan E. , Craig Maria E. , Maple‐Brown Louise J. ,   the PANDORA Study Research Team
Published: May 2022

SummaryBackgroundFew studies have assessed whether children exposed to in utero hyperglycaemia experience different growth trajectories compared to unexposed children.ObjectivesTo assess association of type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) with early childhood weight, length/height and body mass index (BMI) trajectories, and with timing and magnitude of peak BMI in infancy.MethodsPANDORA is a birth cohort recruited from an Australian hyperglycaemia in pregnancy register, and women with normoglycaemia recruited from the community. Offspring growth measures were obtained from health records over a median follow‐up of 3.0 years (interquartile range 1.9–4.0). This analysis included children born to Aboriginal mothers with in utero normoglycaemia (n = 95), GDM (n = 228) or T2D (n = 131). Growth trajectories (weight, length/height and BMI) were estimated using linear mixed models with cubic spline functions of child age.ResultsAfter adjustment for maternal factors (age, BMI, parity, smoking, and socioeconomic measures) and child factors (age, gestational age at birth, and sex), children born to mothers with T2D or GDM had lower weight, length/height and BMI trajectories in infancy than children born to mothers with normoglycaemia, but similar weight and BMI by completion of follow‐up. Children exposed to T2D had lower mean peak BMI 17.6 kg/m2 (95% confidence interval [CI] 17.3–18.0) than children exposed to normoglycaemia (18.6 kg/m2 [18.1–18.9]) (p = 0.001).ConclusionsMaternal hyperglycaemia was associated with differences in early childhood growth trajectories after adjustment for maternal BMI. Exploration of associations between in utero hyperglycaemia exposure and growth trajectories into later childhood is required.
Computational drug repositioning using similarity constrained weight regularization matrix factorization: A case of COVID‐19
Authors: Xu Junlin , Meng Yajie , Peng Lihong , Cai Lijun , Tang Xianfang , Liang Yuebin , Tian Geng , Yang Jialiang 
Published: May 2022

AbstractAmid the COVID‐19 crisis, we put sizeable efforts to collect a high number of experimentally validated drug–virus association entries from literature by text mining and built a human drug–virus association database. To the best of our knowledge, it is the largest publicly available drug–virus database so far. Next, we develop a novel weight regularization matrix factorization approach, termed WRMF, for in silico drug repurposing by integrating three networks: the known drug–virus association network, the drug–drug chemical structure similarity network, and the virus–virus genomic sequencing similarity network. Specifically, WRMF adds a weight to each training sample for reducing the influence of negative samples (i.e. the drug–virus association is unassociated). A comparison on the curated drug–virus database shows that WRMF performs better than a few state‐of‐the‐art methods. In addition, we selected the other two different public datasets (i.e. Cdataset and HMDD V2.0) to assess WRMF's performance. The case study also demonstrated the accuracy and reliability of WRMF to infer potential drugs for the novel virus. In summary, we offer a useful tool including a novel drug–virus association database and a powerful method WRMF to repurpose potential drugs for new viruses.
C‐reactive protein perturbs alveolar bone homeostasis: An experimental study of periodontitis and diabetes in the rat
Authors: Zhou Mengjiao , Xu Xiaohui , Li Jie , Zhou Jie , He Yao , Chen Ziqi , Liu Shan , Chen Duanjing , Li Han , Li Guangyue , Huang Jiao , Yang Gangyi , Zhang Tingwei , Song Jinlin 
Published: May 2022

AbstractAimTo explore the role of C‐reactive protein (CRP) in periodontitis and diabetes and its mechanism in alveolar bone homeostasis.Materials and MethodsIn vivo, normal, and Crp knockout (KO) rats were randomly divided into control, diabetes, periodontitis, and diabetes and periodontitis groups, respectively. The diabetes model was established using a high‐fat diet combined with streptozotocin injection. The periodontitis model was established by ligature combined with lipopolysaccharide (LPS) injection. Alveolar bones were analysed using micro‐computed tomography, histology, and immunohistochemistry. In vitro, human periodontal ligament cells (hPDLCs) were treated with LPS and high glucose. CRP knockdown lentivirus or CRP overexpression adenovirus combined with a PI3K/AKT signalling inhibitor or agonist were used to explore the regulatory mechanism of CRP in osteogenesis and osteoclastogenesis of hPDLCs, as evidenced by alkaline phosphatase staining, Western blot, and quantitative polymerase chain reaction.ResultsIn periodontitis and diabetes, CRP KO decreased the alveolar bone loss and the expression levels of osteoclastogenic markers, while increasing the expression levels of osteogenic markers. CRP constrained osteogenesis while promoting the osteoclastogenesis of hPDLCs via PI3K/AKT signalling under high glucose and pro‐inflammatory conditions.ConclusionsCRP inhibits osteogenesis and promotes osteoclastogenesis via PI3K/AKT signalling under diabetic and pro‐inflammatory conditions, thus perturbing alveolar bone homeostasis.
A vitronectin‐derived peptide prevents and restores alveolar bone loss by modulating bone re‐modelling and expression of RANKL and IL‐17A
Authors: Lee Junbeom , Min Hong Ki , Park Cho Yeon , Kang Hyun Ki , Jung Sung Youn , Min Byung‐Moo 
Published: May 2022

AbstractAimThis study investigated whether a vitronectin‐derived peptide (VnP‐16) prevents and/or reverses alveolar bone resorption induced by ligature‐induced periodontitis in rodents and identified the underlying mechanism.Materials and MethodsWe evaluated the effects of VnP‐16 on osteogenic differentiation in human periodontal ligament cells (hPDLCs), lipopolysaccharide‐induced inflammatory responses in gingival fibroblasts, and immune response in T lymphocytes. Ligature‐induced periodontitis was induced by ligating the bilateral mandibular first molars for 14 days in rats and for 7 days in mice (n = 10/group). VnP‐16 (100 μg/10 μl) was applied topically into the gingival sulcus of rats via intra‐sulcular injection, whereas the peptide (50 μg/5 μl) was administered directly into the gingiva of mice via intra‐gingival injection. To evaluate the preventive and therapeutic effects of VnP‐16, micro‐computed tomography analysis and histological staining were then performed.ResultsVnP‐16 promoted osteogenic differentiation of periodontal ligament cells and inhibited the production of lipopolysaccharide‐induced inflammatory mediators in gingival fibroblasts. Concomitantly, VnP‐16 modulated the host immune response by reducing the number of receptor activator of NF‐κB ligand (RANKL)‐expressing lipopolysaccharide‐stimulated CD4+ and CD8+ T cells, and by suppressing RANKL and interleukin (IL)‐17A production. Furthermore, local administration of VnP‐16 in rats and mice significantly prevented and reversed alveolar bone loss induced by ligature‐induced periodontitis. VnP‐16 enhanced osteoblastogenesis and simultaneously inhibited osteoclastogenesis and suppressed RANKL and IL‐17A expression in vivo.ConclusionsOur findings suggest that VnP‐16 acts as a potent therapeutic agent for preventing and treating periodontitis by regulating bone re‐modelling and immune and inflammatory responses.
Association of Medicare bundled payment model with joint replacement care for people with dementia
Authors: Kim Hyunjee , Juarez Cesar A. , Meath Thomas H. A. , Quiñones Ana R. , Teno Joan M. 
Published: May 2022

AbstractBackgroundWe examined whether the Comprehensive Care for Joint Replacement (CJR) model was associated with changes in the receipt of joint replacement among people with Alzheimer's disease and related dementias (ADRD) as well as spending, health service use, and postsurgical outcomes among people with ADRD who underwent a joint replacement surgery.MethodsRetrospective cohort study using 2013–2017 Medicare claims and Minimum Data Set. We used a difference‐in‐differences analysis to compare people with ADRD residing in CJR‐participating treatment areas versus nonparticipating control areas on the receipt of joint replacement, episode spending during the index hospitalization and subsequent 90‐day post‐discharge period, discharges to an institutional post‐acute care setting, and readmissions within 90 days of hospital discharge.ResultsOur sample included 3,361,950 Medicare enrollees with ADRD (2,156,995 women [64%]; mean [SD] age, 83 [8.0] years; 2,646,405 white [78%], 344,478 black [10%], 224,010 Hispanic [7%]). The receipt of replacement among people with ADRD changed similarly between CJR‐participating treatment and control areas after CJR model was implemented, suggesting no association of CJR model with the receipt of replacement. Among people with ADRD who received joint replacement, the CJR model was associated with a $1029 decrease in spending per episode (95% confidence interval [CI] −$1577, −$481, p < 0.001), a 1.62 percentage point decrease in discharges to an institutional post‐acute care setting (95% CI −3.17, −0.07, p = 0.04), but no changes in 90‐day readmission (95% CI −2.68, 0.00, p = 0.051).ConclusionsDespite concerns that the CJR model could hinder people with ADRD from receiving joint replacement, the receipt of joint replacement did not change among people with ADRD under CJR. The CJR model was associated with decreased spending for people with ADRD who received joint replacements, driven by reduced discharges to an institutional post‐acute care setting, without any changes in 90‐day readmission.
Effect of global warming on dermatology practice: The increase in cases of cutaneous larva migrans in the eastern Black Sea region of Turkey
Authors: Can İlkay , Yürekli Aslan 
Published: May 2022

AbstractObjectiveCutaneous larva migrans (CLM) is a parasitic disease seen in people in contact with soil in tropical countries. Almost all cases reported in regions without a tropical climate have a history of travel to a tropical region.AimIn our study, we aimed to investigate the effect of climate change on CLM cases and the demographic characteristics of these cases. For this purpose, the climate information of the period in which we determined the case series and the characteristics of the patients were investigated.Material and MethodThe study was designed retrospectively. Patient files and pre‐ and post‐treatment photographic archives were reviewed retrospectively. In addition, the region's weather history over the last 50 years was examined.ResultsThe records of patients diagnosed with CLM in 2018 were reviewed retrospectively. In total, 22 cases were detected. The common feature of all cases was that they worked as tea pickers. After examining the weather conditions of the period when the cases were commonly reported, it was determined that there was a sharp temperature increase compared with previous years.ConclusionDue to climate change, an increase in the number of CLM cases is observed in non‐tropical regions. Since it is considered a disease‐specific to tropical regions, the diagnosis may be overlooked in cases outside these regions. However, CLM should be kept in mind as a diagnostic possibility by clinicians practicing in non‐tropical regions as well, especially when treating patients who work with soil, such as tea harvesters.
Presidential Address: Corporate Finance and Reality
Authors: GRAHAM JOHN R. 
Published: May 2022

ABSTRACTThis paper uses surveys to document CFO perspectives on corporate planning, investment, capital structure, payout, and shareholder versus stakeholder focus. Comparing policy decisions today to those 20 years ago, I find that companies employ decision rules that are conservative, sticky, and geared to time the market; rely on internal forecasts that are miscalibrated and considered reliable only two years ahead; and emphasize corporate objectives that focus increasingly on stakeholders and revenues. These practice of corporate finance themes can discipline academic models toward better explaining outcomes. Models of satisficing decision‐making or costly managerial biases align with many of the themes.
Lighting, signing, showing: The circulability of Pink Dot's counterpublic discourse in Singapore
Authors: Pak Vincent 
Published: May 2022

AbstractPink Dot, a homegrown LGBTQ activist group based in Singapore, has been treated as a social movement since its inauguration in 2009, and they organise an annual event to advocate for LGBTQ individuals. In 2020, due to the coronavirus pandemic, the twelfth edition of the event (PD12) took place online as a livestream on YouTube. The highlight of PD12 was the unveiling of a ‘digital pink dot’ via a virtual map of Singapore, where the permeability of its discourse in virtual and physical spaces became much more apparent in comparison with previous physical iterations of the event. Approaching the data with counterpublic and citizenship theory, I outline the circulability of discourse as the key feature of a counterpublic, and argue that PD12 achieves this in two ways: (i) the semiotic fragmentation of its physical signs and online discourse; and (ii) the deployment of intertextual elements in a drag performance.
Three‐dimensional and catheter‐based intracardiac echocardiographic characterization of the interatrial septum in 2 horses with suspicion of a patent foramen ovale
Authors: Vernemmen Ingrid , Paulussen Ellen , Dauvillier Julie , Decloedt Annelies , van Loon Gunther 
Published: May 2022

AbstractThis case report describes the 2‐dimensional transthoracic (2D‐TTE), 3‐dimensional transthoracic (3D‐TTE) and intracardiac echocardiographic (ICE) characterization of the fossa ovalis region in 2 horses. The first case was presented for poor performance and showed an anechoic zone in the interatrial septum on 2D‐TTE. Based on 3D‐TTE a deepened fossa ovalis could be identified and using ICE the presence of an interatrial shunt could be excluded. The second case was referred for a cardiac murmur and the presence of turbulent flow in and around the interatrial septum on 2D‐TTE color flow Doppler. The complementary use of 2D‐TTE, 3D‐TTE, and ICE allowed detailed characterization of a patent foramen ovale, with evidence of a left‐to‐right shunt in a dorsocranial to ventrocaudal direction with limited hemodynamic implications. These 2 cases underline the feasibility of 3D‐TTE and ICE in horses and especially show the added value of ICE in a clinical setting.
Incidence and outcomes of thromboembolic and bleeding events in patients with liver cirrhosis in the USA
Authors: Huang Xiaoquan , Abougergi Marwan S. , Sun Chenyu , Murphy Dermot , Sondhi Vikram , Chen Bing , Zheng Xin , Chen Shiyao , Wang Yichen 
Published: May 2022

AbstractBackground & aimsUnderstanding the epidemiology of bleeding and thromboembolism (clotting) in liver cirrhosis provides important data for future studies and policymaking; however, head‐to‐head comparisons of bleeding and clotting remain limited.MethodsThis is a populational retrospective cohort study using the US National Readmission Database of 2018 to compare the incidence and outcomes of bleeding and clotting events in patients with liver cirrhosis. The primary outcomes were the 11‐month incidence proportion of bleeding and clotting events.ResultsOf 1 304 815 participants, 26 569 had liver cirrhosis (45.0% women, mean age 57.2 [SD, 12.7] years). During the 11‐month follow‐up, in patients with cirrhosis, for bleeding and clotting events, the incidence proportions was 15.3% and 6.6%; the risk‐standardized all‐cause mortality rates were 2.4% and 1.0%; the rates of intensive care intervention were 4.1% and 1.9%; the rates of rehabilitation transfer were .2% and .2%; the cumulative length of stays were 45 100 and 23 566 days; total hospital costs were 147 and 84 million US dollars; total hospital charges were 620 and 365 million US dollars. Compared to non‐cirrhosis, liver cirrhosis was associated with higher rates of bleeding (adjusted hazard ratio, 3.02 [95% CI, 2.85–3.20]) and portal vein thrombosis (PVT) (18.46 [14.86–22.92]), and slightly lower risks of other non‐PVT venous thromboembolic events (.82 [.75–.89]).ConclusionsBleeding is more common than thromboembolism in patients with liver cirrhosis, causes higher morbidity, mortality and resource utilization. Liver cirrhosis is an independent risk factor for bleeding and PVT, but not non‐PVT thromboembolism including venous thromboembolism, acute myocardial infarction and ischemic stroke.