bluuebunny/crossref_metadata_2025_split huggingface dataset:
From individual responses to population effects: Integrating a decade of multidisciplinary research on blue whales and sonar
Authors: Pirotta E. , Booth C. G. , Calambokidis J. , Costa D. P. , Fahlbusch J. A. , Friedlaender A. S. , Goldbogen J. A. , Harwood J. , Hazen E. L. , New L. , Santora J. A. , Watwood S. L. , Wertman C. , Southall B. L. 
Published: April 2022

AbstractAs ecosystems transform under climate change and expanding human activities, multidisciplinary integration of empirical research, conceptual frameworks and modelling methods is required to predict, monitor and manage the cascading effects on wildlife populations. For example, exposure to anthropogenic noise can lead to changes in the behaviour and physiology of individual marine mammals, but management is complicated by uncertainties on the long‐term effects at a population level. We build on a decade of diverse efforts to demonstrate the strengths of integrating research on multiple stressors for assessing population‐level effects. Using the case study of blue whales exposed to military sonar in the eastern north Pacific, we model how behavioural responses and environmental effects induced by climate change affect female survival and reproductive success. Environmental changes were predicted to severely affect vital rates, while the current regime of sonar activities was not. Simulated disturbance had a stronger effect on reproductive success than adult survival, as predicted by life‐history theory. We show that information on prey resources is critical for robust predictions, as are data on baseline behavioural patterns, energy budgets, body condition and contextual responses to noise. These results will support effective management of the interactions between sonar operations and blue whales in the study area, while providing pragmatic guidance for future data collection to reduce key uncertainties. Our study provides important lessons for the successful integration of multidisciplinary research to inform the assessment of the effects of noise and other anthropogenic stressors on marine predator populations in the context of a changing environment.
Genomic analysis of 10 years of artificial selection in community‐based breeding programs in two Ethiopian indigenous sheep breeds
Authors: Rekik Emna , Ahbara Abulgasim M. , Abate Zelalem , Goshme Shenkute , Getachew Tesfaye , Haile Aynalem , Rischkowsky Barbara , Mwacharo Joram M. 
Published: April 2022

SummaryIn recent times, community‐based breeding programs (CBBPs) have been advocated as the best strategy for genetic improvement of local breeds in smallholder farms in developing countries. Since 2009, CBBPs have been implemented for Ethiopian Bonga and Menz sheep to improve growth rates resulting in significant genetic gains in 6‐month weights. With the hypothesis that selection could be impacting their genomes, we systematically screened for possible genome changes in the two breeds by analyzing 600K BeadChip genotype data of 151 individuals (with the highest breeding values for 6‐month weights) from CBBP flocks against 98 individuals from non‐CBBP flocks. We observed no differences in genetic diversity and demographic dynamics between CBBP and non‐CBBP flocks. Selection signature analysis employing ROH, logistic regression genome‐wide association study ,FST, XP‐EHH and iHS revealed 5 (Bonga) and 11 (Menz) overlapping regions under selection, that co‐localized with QTLs for production (body size/weight, growth, milk yield), meat/milk quality, and health/parasite resistance, suggesting that the decade‐long selection has likely started to impact their genomes. However, genome‐wide genetic differentiation between the CBBP and non‐CBBP flocks is not yet clearly evident.
Scrutinising the role of simvastatin in a patient of Pachyonychia Congenita with KRT6A gene mutation
Authors: Sharma Shruti , Dayal Surabhi , Aggarwal Kamal , Gowda V.M Varsha , Kaur Rupinder 
Published: April 2022

ABSTRACTA 25‐year‐old male patient presented with palmoplantar keratoderma, dystrophic nails, severe plantar pain and oral leukokeratosis since birth. On genetic analysis, a heterozygous KRT6A gene missense mutation (c.1381G > A, p.Glu461Lys in exon 7) was identified by next‐generation sequencing technology, consistent with pachyonychia congenita 6a. Oral simvastatin 40 mg was started once daily, and after 16 weeks of therapy, excellent improvement was noted in palmoplantar keratoderma and plantar pain. The maximum thickness of his foot callosity reduced by 4 mm on ultrasonography, and the Dermatology Life Quality Index score dropped significantly by eight points. These benefits may be attributed to inhibition of KRT6A gene expression, modulation of autophagy and mitophagy and Keap1‐Nrf2 signalling activation; the latter two mechanisms of statins previously undiscussed in the context of pachyonychia congenita. Simvastatin and other statins are pathogenesis‐targeted, disease‐modifying therapy in pachyonychia congenita, therefore qualifying as a promising treatment avenue and warranting further clinical trials.
Guidelines for the peri‐operative management of people with cardiac implantable electronic devices
Authors: Thomas H. , Plummer C. , Wright I. J. , Foley P. , Turley A. J. 
Published: April 2022

SummaryThis document provides practical guidance for the management of people with cardiac implantable electronic devices who are undergoing surgical intervention. Increasing numbers of people have cardiac device implants including pacemakers, implantable defibrillators and cardiac resynchronisation devices. During surgical procedures, exposure to electromagnetic interference may lead to inappropriate device function including withholding of pacing function or shock therapies. The guideline summarises key aspects of pre‐operative assessment protocols to ensure that all people have their device clearly identified and have had appropriate device follow‐up pre‐operatively. It outlines general measures which can minimise the risk of potentially problematic electromagnetic interference in the surgical environment. It also includes detailed guidance according to the type of device, whether individuals are dependent on the pacing function of the device and the nature of the procedure they are undergoing. People identified as being at significant risk of harmful procedure‐related inappropriate device function may require temporary alteration to the device programming. This may be carried out by a trained cardiac physiologist using a device programmer or, in some cases, can be achieved by clinical magnet application. Guidance on the safe use of magnets and emergency situations is included. Common diagnostic procedures and dental interventions are covered. The guidance aims to provide specific and pragmatic advice which can be applied to provide safe and streamlined care for people with cardiac implantable devices.
Rapid wide QRS tachycardia with an unknown cause
Authors: Hu Dalong , Li Jingxiu 
Published: April 2022

AbstractOne‐to‐one atrioventricular conduction during atrial flutter is one of the most severe life‐threatening arrhythmias and is hemodynamically perilous. Rapid wide QRS tachycardia often not only occurs in patients with ventricular tachycardia but is also found in supraventricular tachycardia/atrial flutter with preexistent QRS prolongation, supraventricular tachycardia/atrial flutter with QRS prolongation caused by an IC antiarrhythmic drug, and supraventricular tachycardia/atrial flutter with preexcitation. Furthermore, atrial flutter with 1:1 AVC via an accessory pathway is an uncommon presentation of Wolff‐Parkinson–White syndrome. We present a case of atrial flutter with 1:1 rapid AVC in the presence of Wolff–Parkinson–White syndrome. Physicians should be familiar with the rapid wide QRS complex ECG pattern associated with AFL with 1:1 AVC via an accessory pathway. Establishing the definitive diagnosis is essential for selecting an appropriate treatment strategy for improving outcomes.
Getting a grip in the middle of chaos: Preparing for preterm parenthood during a high‐risk pregnancy – Parental experiences and needs
Authors: Ruhe Kiki , van den Hoogen Agnes , Bröring‐Starre Tinka , Wielenga Joke M. , van Weissenbruch Mirjam M. 
Published: April 2022

AbstractAimAdmitting an infant to a neonatal intensive care unit (NICU) is stressful for parents. A great source of stress is the loss of their desired parental role. This study explores parents’ experiences and needs during a high‐risk pregnancy in preparation for their role as parents of a preterm infant.MethodsAn exploratory qualitative study was conducted among parents with a preterm infant admitted to two level‐III NICUs in the Netherlands. A thematic analysis was performed.ResultsNineteen interviews were conducted with parents of preterm infants (26–34 weeks gestational age). Getting a grip in the middle of chaos was identified as the central theme. In the pre‐admission phase, coping with potential preterm parenthood was a theme, with coping strategies as subthemes that changed over time from avoidance to being ready to parent a preterm infant. The theme envisioning the NICU emerged in the NICU admission phase, with subthemes preterm care journey and opportunities for involvement fostering parental empowerment.ConclusionTiming and content of information about a parental role in the NICU should be tailored to the individual expectant parent. A customisable intervention bundle may provide a vision of the NICU and the parents’ active role in care.
Letter: association between COVID‐19 and inflammatory bowel disease
Authors: Chen Hui‐Yuan , Wang Shiow‐Ing , Chang Renin , Wei James Cheng‐Chung 
Published: April 2022

LINKED CONTENTThis article is linked to Hadi et al. papers. To view these articles, visit https://publons.com/publon/10.1111/apt.16730 https://doi.org/10.1111/apt.16900
Editorial: the importance of utilising gastrointestinal ultrasound via transperineal approach in ulcerative colitis—an accurate early predictor of response to treatment
Authors: Ardalan Zaid S. , Friedman Antony B. 
Published: April 2022

LINKED CONTENTThis article is linked to Sagami et al papers. To view these articles, visit https://doi.org/10.1111/apt.16817 and https://doi.org/10.1111/apt.16895
Letter: COVID‐19 outcomes and anti‐TNF treatments—comprehensive evidence matters
Authors: Hung Cheng‐Hsien , Yang Tsung‐Yuan , Wei James Cheng‐Chung 
Published: April 2022

LINKED CONTENTThis article is linked to Kokkotis et al papers. To view these articles, visit https://doi.org/10.1111/apt.16717 and https://doi.org/10.1111/apt.16904
Editorial: shedding new light on extraintestinal manifestations in inflammatory bowel disease
Authors: Guillo Lucas , Peyrin‐Biroulet Laurent , Danese Silvio 
Published: April 2022

LINKED CONTENTThis article is linked to Falloon et al papers. To view these articles, visit https://doi.org/10.1111/apt.16853 and https://doi.org/10.1111/apt.16907
Editorial: screening for hepatocellular carcinoma in NAFLD—towards abbreviated MRI alternative in patients with obesity?
Authors: Lebossé Fanny , Caussy Cyrielle 
Published: April 2022

LINKED CONTENTThis article is linked to Huang et al papers. To view these articles, visit https://doi.org/10.1111/apt.16844 and https://doi.org/10.1111/apt.16908
Editorial: the importance of utilising gastrointestinal ultrasound via transperineal approach in ulcerative colitis—an accurate early predictor of response to treatment. Authors' reply
Authors: Sagami Shintaro , Kobayashi Taku 
Published: April 2022

LINKED CONTENTThis article is linked to Sagami et al papers. To view these articles, visit https://doi.org/10.1111/apt.16817 and https://doi.org/10.1111/apt.16868
Editorial: Lyon consensus metrics—towards personalised diagnosis of non‐erosive reflux disease
Authors: Sawada Akinari , Gyawali C. Prakash 
Published: April 2022

LINKED CONTENTThis article is linked to Frazzoni et al papers. To view these articles, visit https://doi.org/10.1111/apt.16838 and https://doi.org/10.1111/apt.16911
Letter: association between COVID‐19 and inflammatory bowel disease—Authors' reply
Authors: Hadi Yousaf , Kochhar Gursimran S. 
Published: April 2022

LINKED CONTENTThis article is linked to Hadi et al papers. To view these articles, visit https://doi.org/10.1111/apt.16730 and https://doi.org/10.1111/apt.16814
Editorial: shedding new light on extraintestinal manifestations in inflammatory bowel disease—authors’ reply
Authors: Falloon Katherine , Cohen Benjamin , Rieder Florian 
Published: April 2022

LINKED CONTENTThis article is linked to Falloon et al papers. To view these articles, visit https://doi.org/10.1111/apt.16853 and https://doi.org/10.1111/apt.16882
Editorial: risky business. What do sufferers' perceptions of risk from interventions for irritable bowel syndrome really mean?
Authors: Quigley Eamonn M. M. 
Published: April 2022

LINKED CONTENTThis article is linked to Goodoory et al papers. To view these articles, visit https://doi.org/10.1111/apt.16816 and https://doi.org/10.1111/apt.16917
Editorial: Lyon consensus metrics—towards personalised diagnosis of non‐erosive reflux disease: Authors' reply
Authors: Frazzoni Marzio , Frazzoni Leonardo , Ribolsi Mentore , De Bortoli Nicola , Savarino Edoardo 
Published: April 2022

LINKED CONTENTThis article is linked to Frazzoni et al papers. To view these articles, visit https://doi.org/10.1111/apt.16838 and https://doi.org/10.1111/apt.16899
Editorial: risky business. What do sufferers' perceptions of risk from interventions for IBS really mean? Authors' reply
Authors: Goodoory Vivek C. , Ng Cho Ee , Black Christopher J. , Ford Alexander C. 
Published: April 2022

LINKED CONTENTThis article is linked to Goodoory et al papers. To view these articles, visit https://doi.org/10.1111/apt.16816 and https://doi.org/10.1111/apt.16909
Model-Based Clustering of High-Dimensional Longitudinal Data via Regularization
Authors: Yang Luoying , Wu Tong Tong 
Published: April 2022

AbstractWe propose a model-based clustering method for high-dimensional longitudinal data via regularization in this paper. This study was motivated by the Trial of Activity in Adolescent Girls (TAAG), which aimed to examine multilevel factors related to the change of physical activity by following up a cohort of 783 girls over 10 years from adolescence to early adulthood. Our goal is to identify the intrinsic grouping of subjects with similar patterns of physical activity trajectories and the most relevant predictors within each group. The previous analyses conducted clustering and variable selection in two steps, while our new method can perform the tasks simultaneously. Within each cluster, a linear mixed-effects model (LMM) is fitted with a doubly penalized likelihood to induce sparsity for parameter estimation and effect selection. The large-sample joint properties are established, allowing the dimensions of both fixed and random effects to increase at an exponential rate of the sample size, with a general class of penalty functions. Assuming subjects are drawn from a Gaussian mixture distribution, model effects and cluster labels are estimated via a coordinate descent algorithm nested inside the Expectation-Maximization (EM) algorithm. Bayesian Information Criterion (BIC) is used to determine the optimal number of clusters and the values of tuning parameters. Our numerical studies show that the new method has satisfactory performance and is able to accommodate complex data with multilevel and/or longitudinal effects.
Initial evaluation of a therapist‐supported online cognitive therapy self‐help for patients with taboo obsessions
Authors: Olofsdotter Lauri Klara , Aspvall Kristina , Bagøien Hustad Ingvill , Malmqvist Karin , Serlachius Eva , Mataix‐Cols David , Rück Christian , Ivanov Volen , Andersson Erik 
Published: April 2022

AbstractObjectivesThe current study evaluated the feasibility of an internet‐delivered cognitive therapy (I‐CT) in a self‐help format with minimal therapist support for patients with obsessive–compulsive disorder (OCD) with primary taboo obsessions. Specifically, the aims were to investigate (1) whether participants were able to grasp and apply the internet‐delivered cognitive framework to their own situation; (2) whether they had clinically meaningful reductions of OCD symptom severity; and (3) whether reduced negative appraisals (hypothesized mechanism of change in CT) preceded reductions in OCD symptom severity.MethodNineteen OCD patients with primary taboo obsessions, recruited from an OCD clinic or self‐referrals, received the I‐CT intervention for 10 weeks. I‐CT did not contain any systematic exposure or response prevention.ResultsAdherence and engagement with the intervention was high. Most participants (n = 13, 68%) understood and successfully applied the cognitive model to their own situation. Within‐group analyses showed large reductions in OCD symptom severity at post‐treatment (bootstrapped within group d = 1.67 [95% CI; 0.67 to 2.66]) measured with the Yale–Brown Obsessive–Compulsive Scale. The gains were maintained at the 6‐month follow‐up. Post‐hoc analyses revealed that the large reductions in OCD symptom severity were driven by the participants who understood the cognitive model. Reductions in negative appraisals predicted subsequent reductions in OCD symptom severity during treatment.ConclusionIt is possible to adapt a purely cognitive intervention to a digital guided self‐help format and to achieve both cognitive change and meaningful symptom reduction. The results require confirmation in a randomized clinical trial.
Efficacy comparison of oxcarbazepine and levetiracetam monotherapy among patients with newly diagnosed focal epilepsy in China: A multicenter, open‐label, randomized study
Authors: Zhu Haoyue , Deng Xuejun , Feng Li , Lian Yajun , Han Xiong , Guo Zhenli , Gou Yulan , Du Yuanmin , Xie Longshan , Yao Dongai , Liu Yonghong , Wu Qiang , Lan Song , Liu Kaisheng , Zhan Peiyan , Wang Xiahong , Dang Jingxia , Hou Yunqi , Chen Keqiang , Zhu Yulan , Shi Yuliang , Yu Yunli , Xiao Bo , Zhu Suiqiang , Meng Hongmei 
Published: April 2022

AbstractAimsThis multicenter, open‐label, randomized study (Registration No. ChiCTR‐OCH‐14004528) aimed to compare the efficacy and effects of oxcarbazepine (OXC) with levetiracetam (LEV) as monotherapies on patient quality of life and mental health for patients with newly diagnosed focal epilepsy from China.MethodsPatients with newly diagnosed focal epilepsy who had experienced 2 or more unprovoked seizures at greater than a 24‐h interval during the previous year were recruited. Participants were randomly assigned to the OXC group or LEV group. Efficacy, safety, quality of life, and mental health were evaluated over 12‐week and 24‐week periods.ResultsIn total, we recruited 271 newly diagnosed patients from 23 centers. Forty‐four patients were excluded before treatment for reasons. The rate of seizure freedom of OXC was significantly superior to that of LEV at 12 weeks and 24 weeks (p < 0.05). The quality of life (except for the seizure worry subsection) and anxiety scale scores also showed significant differences from before to after treatment in the OXC and LEV groups.ConclusionsOXC monotherapy may be more effective than LEV monotherapy in patients with newly diagnosed focal epilepsy. Both OXC and LEV could improve the quality of life and anxiety state in adult patients with focal epilepsy.
When is it safe for the liver donor to be discharged home and prevent unnecessary re‐hospitalizations? – A systematic review of the literature and expert panel recommendations
Authors: Mazzola Alessandra , Pittau Gabriella , Hong Suk Kyun , Chinnakotla Srinath , Tautenhahn Hans‐Michael , Maluf Daniel G. , Settmacher Utz , Spiro Michael , Raptis Dimitri Aristotle , Jafarian Ali , Cherqui Daniel ,   the ERAS4OLT.org Working Group
Published: April 2022

AbstractBackgroundFew data are available on discharge criteria after living liver donation (LLD).ObjectivesTo identify the features for fit for discharge checklist after LLD to prevent unnecessary re‐hospitalizations and to provide international expert recommendations.Data sourcesOvid MEDLINE, Embase, Scopus, Google Scholar, and Cochrane Central.MethodsSystematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel. The critical outcomes included were complications rates and liver function (defined by elevated bilirubin and INR) (CRD42021260725).ResultsTotal 57/1710 studies were included in qualitative analysis and 28/57 on the final analysis. No randomized controlled trials were identified. The complications rate was reported in 20/28 studies and ranged from 7.8% to 71.2%. Post hepatectomy liver function was reported in 13 studies. The Quality of Evidence (QoE) was Low and Very‐Low for complications rate and liver function test, respectively.ConclusionsMonitoring and prevention of donor complications should be crucial in decision making of discharge. Pain and diet control, removal of all drains and catheters, deep venous thrombosis prophylaxis, and use routine imaging (CT scan or liver ultrasound) before discharge should be included as fit for discharge checklist (QoE; Low | GRADE of recommendation; Strong). Transient Impaired liver function (defined by elevated bilirubin and INR), a prognostic marker of outcome after liver resection, usually occurs after donor right hepatectomy and should be monitored. Improving trends for bilirubin and INR value should be observed by day 5 post hepatectomy and be included in the fit for discharge checklist. (QoE; Very‐Low | GRADE; Strong).
The optimal use of chlormethine gel for mycosis fungoides: An expert consensus from Germany, Austria and Switzerland (DACH region)
Authors: Assaf Chalid , Booken Nina , Dippel Edgar , Guenova Emmanuella , Jonak Constanze , Klemke Claus‐Detlev , Nicolay Jan P. , Schlaak Max , Wobser Marion , Trautinger Franz 
Published: April 2022

SummaryBackgroundIn Europe chlormethine gel is licensed for the management of patients with mycosis fungoides of all stages. However, the optimal regimen regarding frequency and dosing as well as combination and maintenance therapy is not well established.MethodsTen experts experienced in research and management of cutaneous T‐cell lymphomas from Germany, Austria, and Switzerland (DACH region) were asked in written form to report on indication for chlormethine gel, frequency of use, monitoring, concomitant therapies, adverse effects, combination therapies in later stages of the disease, maintenance therapy, and adherence to this therapy for mycosis fungoides. The structured answers were discussed in a consensus conference and recommendations were developed.ResultsEssential for therapy with chlormethine gel is an individualized and symptom‐oriented management. Because of the lack of systemic resorption of topically administered chlormethine gel, systemic adverse events are unlikely. An allergic or irritative‐toxic contact dermatitis is common but manageable with adaptation of the regimen, interruption of administration, and symptom‐specific supportive measurements. A step‐up initial approach with application of chlormethine gel every other day is associated with a better tolerability, especially if it is alternated with topical corticosteroids.ConclusionsThe use of chlormethine gel in the management of mycosis fungoides is often limited by a concomitant contact dermatitis. An adequate therapeutic regimen and the management of adverse effects can preclude an unnecessary withdrawal of therapy so that more patients can benefit from this treatment option.