bluuebunny/crossref_metadata_2025_split huggingface dataset:
The landscape and ecological framework as a territorial basis for stable development in Russia’s agricultural regions
Authors: Chibilеv A. A. 
Published: July 2022

Forming a landscape‐ecological framework is an urgent task supporting the adoption of a strategy for the progress of specially protected natural territories in Russia by 2030. According to the author, the strategy does not fully reflect the specifics of the development of the network of territorial nature protection objects in the agricultural regions of the country.Aim Substantiate proposals for optimizing the network of protected areas.Materials and Methods. Methods of cartographic analysis of schemes of physical and geographical zoning, generalisation of the results of expedition research, assessment of the representativeness of the existing network of protected areas and a comparative assessment of the most valuable landscape and natural biotic plots were used in the paper.Results. As a result of this study a complex of new and promising sites has been identified for inclusion in the landscape and ecological framework, which can constitute the natural reserve fund of the regions as clusters. The study covers steppe and forest‐steppe landscapes of southern European and Asian Russia. The problem has been considered in the context of subjects relating to physical and geographical zoning. Proposals for the modernisation and expansion of the network of objects included in the landscape and ecological framework were compiled based on expedition studies, combined with quantitative and qualitative indicators of natural diversity.Conclusions There is a need to modernise the existing network and to create new nature reserves based, among other things, on as‐yetunrealised projects for the creation of reserves.
Air pollution: A threat to health tourism development in the Islamic Republic of Iran (case study: Ilam city)
Authors: Hosseini S. S. , Taghvaei M. , Seidaiy E. S. , Gholami Y. , Ataev Z. V. 
Published: July 2022

Aim. Considering the high capability of Ilam province in the development of health tourism as indicated in its active border crossings with Iraq and the response to the recent epidemic, it was deemed necessary to identify the risks of air pollution on the health of tourists.Materials and Methods. During 2008‐2018, data on five primary air pollutants during 2008‐2018 were identified by literature research and by referring to the relevant monitoring organizations. Data analysis was performed by the Full permutation polygon synthetic indicator model, while Excel and MATLAB software were used to display data.Results. The findings of the study revealed that despite the application of the Land Use Planning Document, average suspended particulate matter of less than 10 microns ranked second after sulphur dioxide (SO2), in terms of the contribution to air pollution and instability in Ilam City during the 11 years in question (excluding 2008 and 2009).Conclusions. The link between air pollution and the development of health tourism on the one hand and the emergence of an epidemic on the other has recently necessitated a new concept of health, tourism and welfare in relation to the environment with the aim of achieving a healthy environment for visiting tourists.
Specific features of accumulation of heavy metals in the body of mollusks (Molluska: Limacidae) of the southern slope of the Aragats mountain range
Authors: Hovhannisyan V. S. , Arutyunova L. D. , Mirumyan L. S. , Magomedova M. Z. , Magomedova P. D. , Poghosyan T. E. 
Published: July 2022

Aim. The aim of this work is the study of the specifics of accumulation of heavy metals in the body of gastropod mollusks ‐ slugs (Molluska: Limacidae) on the southern slope of the Aragats mountain range, namely, conducting a quantitative analysis of heavy metals in the soil of different points of the Aragats mountain range and in the body of slugs (Vitrinoides monticola armeniaca; Deroceras caucasicum; Limax flavus), as well as the principles of biogenic migration of heavy metals according to the soil– plant–animal system (slugs) and determining the role of slugs in this migration in terrestrial ecosystems.Material and Methods. Slugs collected from different points of the southern slope of the Aragats mountain range served as material for this study. The content of heavy metals (Cu, Zn, Pb, Ca, Mo) in the body of the mollusks was determined by the Atomic Absorption Spectrophotometry method: AAS extraction & ISO‐8288. The features of the biological accumulation of heavy metals in the body of mollusks were also determined.Results. Gastropod mollusks (Molluska: Limacidae) actively accumulate heavy metals (especially Cu, Zn, Ca) in their bodies and play a certain role in their transfer through food chains. Slugs, living in upper soil horizons (mesofauna) and under stones and plant litter, actively respond to the slightest changes in the environment and are perspective objects allowing the detection of deviations in the functioning of soils and the natural complex as a whole.Conclusion. Slugs living in the soil are an important link of the biogenic migration of heavy metals. An inverse relationship was revealed between the total and removable number of heavy metals in migration through the system: soil–plant–organism.
Evaluation of seed germination and growth activity of plants of Dianthus awaricus Khar. in the conditions of inner mountain Dagestan
Authors: Osmanov R. M. , Guseynova Z. A. , Alibegova A. N. 
Published: July 2022

Aim. Study of the growth dynamics of Dianthus awaricus plants in field experimental conditions and of laboratory germination of seeds obtained in the introduction experiment.Material and Methods. Samples of D. awaricus seeds collected in natural populations along the altitudinal ecocline from 820 to 1,720 m above sea level served as the material for the study. To study the field germination and growth dynamics of the plants, D. awaricus seeds were sown at two experimental bases of the Mountain Botanical Garden (at 1,100 and 1,750 m above sea level). Evaluation of laboratory germination was carried out using seeds collected at the Tsudakhar base.Results. Comparative characteristics of the average values of the shoot length and the number of lateral branches of the studied samples showed that the differences between the populations are significant. The monthly increase in D. awaricus plants of different accessions also differs. Monthly variability of the shoot length of D. awaricus in the tested accessions is at a high level, the expressivity of which, apparently, is significantly affected by a complex of environmental factors. A study of the germination of D. awaricus seeds showed that it is higher under laboratory conditions than under experimental field conditions. The highest percentage of seed germination was observed in the “Gunib” sample: 64.0% in the laboratory and 28.6% in the field at the Tsudakhar base.Conclusions. Differences were noted in growth dynamics in the studied samples of D. awaricus studied, apparently due to a complex of abiotic and biotic environmental factors. For the “Tsudakhar” samples the experimental conditions and place of collection of seed material were identical but for the other two samples they were different from their natural habitat. The low field germination of D. awaricus seeds is probably due to the negative impact of winter drought and adverse weather conditions in the spring.
Herbaceous Riparian Ecotonal Species along the Dzücha River, Kohima, Nagaland and Their Ethnomedicinal Uses
Authors: Keretsu Khrielietuo , Singh Maibam Romeo , Temjen Wati 
Published: July 2022

Background: Riparian vegetation maintains the river ecosystem. This vegetation acts as a filter for the water body. The vegetation also hosts naturally rich flora which the tribal people utilize as traditional herbal drug. With the increase in anthropogenic disturbance, there is a need to document and inventory this rich bioresource. Methods: Vegetation analysis of the Dzücha River was conducted by line transect quadrat method and the diversity Indices were recorded. Ethnobotanical information on the traditional use of the various plants was collected via oral interviews with the indigenous inhabitants. Result: A total of 31 species belonging to 15 families were recorded from the study site. Species diversity (Shannon-Wiener Index) = 2.775, Species richness (Margalef’s Index) = 4.163, Species evenness (Pielou’s Evenness) = 0.808 and Species dominance (Simpson’s Index) = 0.101, were reported. Maximum IVI (38.45) value was recorded for Ageratina riparia. 11 herbaceous species in the study site were utilized as ethno medicinal items. Such traditional knowledge of medicinal plant species is crucial for the development of novel drugs.
Meningkatkan Aktivitas dan Hasil Belajar Fisika Siswa Menggunakan Media CD Program Dengan Pendekatan Tutorial Di SMP
Authors: Yuversa Edi , T Bahari , Hendri Menza 
Published: July 2022

Upaya untuk memperbaiki kualitas pembelajaran dikelas adalah suatu kewajiban bai guru sebagai salah satu usaha untuk mewujudkan tujuan pendidikan nasional di Indonesia. Telah dilakukan peneltian dengan menggunakan metode Penelitian Tindakan Kelas (Classroom Action Research) pada 32 orang siswa dengan tujuan untuk mengetahui penigkatan aktivitas dan hasil belajar fisika siswa dengan menggunakan media CD Program melalui pendekatan tutorial.Berdasarkan hasil penelitian disimpulkan bahwa pembelajaran dengan menggunakan media CD Program melalui pendekatan tutorial pada mata pelajaran fisika kelas VIIIc SMP Negeri 7 Muaro Jambi dapat meningkatkan aktivitas dan hasil belajar siswaalam proses pembelajaran jika dilihat dari 3 siklus pembelajaran yang dilakukan. Siklus pertama diperoleh nilai rata-rata 5,08, pada siklus kedua diperoleh nilai rata-rata 6,25 dan pada siklus ketiga diperoleh nilai rata-rata 6,59 dengan peningkatan persentase keberhasilan masing-masing sebesar 31,3%, 53,13%, dan 78,12%.
ERRORS IN THERMAL IMAGERS TEMPERATURE RESOLUTION DETERMINING
Authors: Kolobrodov Valentine , Mykytenko Volodymyr , Tymchik Gregory , Kolobrodov Mykyta , Sokol Bohdan 
Published: July 2022

Thermal imaging methods of environmental observation are often accompanied by the need to quantify the temperature distribution on the object’s surfaces. In such cases, the accuracy of modeling the information conversion processes that occur in thermal imaging systems is essential. All questions concerning the determination of thermal imagers temperature resolution are important. Experimental methods for determining temperature resolution in this sense are quite unambiguous and well-established in practice. And calculation methods are still being refined and are of interest to the scientific community.
The article is devoted to the development of practical methods for calculating the thermal imagers temperature resolution. Such methods must be on the hand one accurate enough, and on the other hand - simple enough to be used in design organizations. The definition of the calculations error is also considered. The calculation model is based on the concept of equivalent noise temperature difference NETD as the most general characteristic of energy transformations in thermal imaging observations. The definition of NETD is based on the use of the thermal imager signal transmission function. A simplified version of the calculation method and an example of determining the temperature resolution for a thermal imager with a microbolometric matrix detector are presented. Such thermal imagers currently occupy a significant part of the market and the calculation of the characteristics of the device with a standard specification may be of interest to specialists. The influence of some elements of the mathematical information transformations model on the temperature resolution is shown. For example, as the background temperature increases, the temperature resolution decreases. The analysis of the proposed calculation model allowed us to outline ways to improve (reduce) temperature resolution. A feature of the developed methods is the possibility of their use for different thermal imaging systems, for example, for polarizing thermal imagers.
Social Movement and Mental Health of South Korean Women Sexual Violence Survivors, 2012–2019
Authors: Kim Chungah , Nielsen Andrew , Teo Celine , Chum Antony 
Published: July 2022

Objectives. To examine whether the #MeToo movement influenced depressive symptoms among women in South Korea with a history of experiencing sexual violence. Methods. We used data from a nationally representative sample (n = 4429) of women 19 to 50 years of age who participated in the Korean Longitudinal Survey of Women and Families between 2012 and 2019. A difference-in-differences model was used to estimate within-person changes in depressive symptoms attributable to the #MeToo movement across women with and without a history of experiencing sexual violence. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression Scale (CESD). Results. After adjustment for potential confounders, the #MeToo movement led to a 1.64 decrease in CESD scores among women with a history of experiencing sexual violence relative to women without such a history. Conclusions. Our findings suggest that the #MeToo movement in Korea led to reduced depressive symptoms among women with a history of experiencing sexual violence. Public Health Implications. Despite the progress of the #MeToo movement, there are still judicial and institutional problems that can revictimize sexual violence survivors. Further policy changes will likely improve the mental health of survivors. (Am J Public Health. 2022;112(9):1337–1345. https://doi.org/10.2105/AJPH.2022.306945 )
Working memory dysfunction in fibromyalgia is associated with genotypes of the catechol- O-methyltransferase gene: An event-related potential study
Authors: Ferrera David , Gómez-Equer Francisco , Peláez Irene , Barjola Paloma , Fernandes-Magalhaes Roberto , Carpio Alberto , De Lahoz María E. , Martín-Buro María Carmen , Mercado Francisco 
Published: July 2022

Abstract

Recent findings have associated different COMT genotypes with working memory capacity in patients with fibromyalgia. Although it is thought that the COMT gene may influence neural correlates (P2 and P3 ERP components) underlying working memory impairment in this chronic pain syndrome, it has not yet been explored. Therefore, the aim of the present research was to investigate the potential effect of the COMT gene in fibromyalgia patients on ERP working memory indices (P2 and P3 components). For this purpose, 102 participants (51 patients and 51 healthy control participants) took part in the experiment. Event-related potentials and behavioural responses were recorded while participants performed a spatial n-back task. Participants had to decide if the stimulus coincided or not in the same location as the one presented one (1-back condition) or two (2-back condition) trials before. Genotypes of the COMT gene were determined through a saliva sample from all participants. Present results significantly showed lower working memory performance (p < 0.05) in patients with fibromyalgia as compared to control participants (higher rate of errors and slower reaction times). At neural level, we found that patients exhibited enhanced frontocentral and parieto-occipital P2 amplitudes compared to control participants (p < 0.05). Interestingly, we also observed that only fibromyalgia patients carrying the Val/Val genotype of the COMT gene showed higher frontocentral P2 amplitudes than control participants (p < 0.05). Current results (behavioural outcomes and P2 amplitudes) confirmed the presence of an alteration in working memory functioning in fibromyalgia. The enhancement of frontocentral P2 could be reflecting that these patients would manifest an inefficient way of activating executive attention processes, in carriers of the Val/Val genotype of COMT. To our knowledge, the present findings are the first linking neural indices of working memory dysfunctions and COMT genotypes in fibromyalgia. Applying a subgroup of patient’s strategy based on this genetic marker could be useful to establish more tailored therapeutical approaches.
Learning experiences of first year graduate entry nursing students: a longitudinal case study
Authors: Winnington Rhona , Shannon Kay , Turner Rosemary , Jarden Rebecca , McClunie-Trust Patricia , Jones Virginia , Merrick Eamon , Donaldson Andrea , Macdiarmid Rachel 
Published: July 2022

Abstract
Background: Graduate entry nursing programmes provide students with an accelerated pathway to becoming a registered nurse. Motivations for study, together with commonly shared characteristics of students enrolling in such programmes is becoming well documented, however, their experiences of studying for a professional qualification in this manner is less understood. As a means of maintaining the relevance of these fast-tracked programmes in the future, an understanding of graduate entry nursing students’ experiences of academic teaching and clinical placements is imperative. Objective: To explore the academic and clinical experiences of students enrolled in the first year of a graduate entry nursing programme.Methods: A longitudinal case study approach was taken based on Yin. Here we report the experiences of nine students enrolled in a graduate entry nursing programme during 2020. Semi-structured interviews were used for data collection and analysed using Braun and Clarke’s thematic analysis. Findings: Three overarching themes were developed - affirmation nursing was the correct career choice, reflections on expectations of a graduate entry nursing programme and the reality of nursing when exposed to clinical placements. Conclusion: This study highlights the experiences of first year graduate entry nursing students, with many experiencing affirmation that their altruistic career visions came to fruition. The findings indicate that many students are flexible and adaptable in their approach to study as a means of meeting the challenges of the programme, all of which are key characteristics for a registered nurse; with the maturing of emotional intelligence providing preparation for their second year of study.
Randomized clinical trial with fractional CO2 laser and Clobetasol in the treatment of Vulvar Lichen Sclerosus: A clinic study of feasibility
Authors: Salgado Hakayna , Drumond Denise , Pannain Gabriel , Costa Louise Gracielle e , Sampaio Fernanda , Leite Isabel 
Published: July 2022

Abstract
Objectives: The main objective of the study was to describe and compare the feasibility of using fractional CO2 laser to the usual treatment with Clobetasol. Randomized clinical trial brought together 20 women from a Brazilian university hospital, 9 of them were submitted to Clobetasol treatment and 11 to laser therapy. Sociodemographic data were obtained and quality of life parameters, vulvar anatomy, self-perception and histopathological analysis of vulvar biopsies were evaluated. Evaluations were made before the beginning of the treatment, during its implementation, right after its completion (3 months), and 12 months after. The SPSS 14.0 program was used, obtaining descriptive measurements. The level of significance adopted was 5%. Results: The clinical/anatomical characteristics of the vulva did not differ between the treatment groups, as much before as after its performance. There was no statistically significant difference between the treatments performed regarding the impact on the life quality of the patients. A higher satisfaction degree with the treatment was obtained with the patients in the Laser group in the third month of evaluation. Laser therapy also revealed a higher occurrence of telangiectasia after treatment completion. Fractional CO2 laser has proven to be well accepted and is a promising therapeutic option.
An AGS-associated mutation in ADAR1 catalytic domain causes early-onset and MDA5- dependent encephalopathy with IFN pathway activation in the brain
Authors: Guo Xinfeng , Steinman Richard A. , Sheng Yi , Chao Guodong , Wiley Clayton A. , Wang Qingde 
Published: July 2022

Abstract
Background:Aicardi-Goutières syndrome (AGS) is a severe autoimmune disease characterized by inflammatory encephalopathy with an elevated Type 1 interferon-stimulated gene (ISG) expression signature in the brain. It is featured by early-onset encephalopathy and progressive loss of intellectual abilities and motor control. Gene mutations in 7 protein-coding genes were found to be associated with AGS. However, the causative role of these mutations in the early-onset neuropathogenesis has not been demonstrated in animal models, and the mechanism of neurodegeneration of AGS remains ambiguous.Methods:Via CRISPR/Cas-9 technology, we established a mutant mouse model in which a genetic mutation found in AGS patients at the ADAR1 coding gene loci was introduced into mouse genome. A mouse model carrying double gene mutations encoding ADAR1 and MDA-5 was prepared through breeding strategy. Phenotype, gene expression, RNA sequencing, innate immune pathway activation, and pathologic studies including RNA in situ hybridization (ISH) and immunohistochemistry (IHC) were used for characterization of the mouse models to determine the disease mechanisms.Results:We established a mouse model bearing a mutation in the catalytic domain of ADAR1, the D1113H mutation found in AGS patients. With this mouse model, we demonstrated a causative role of this mutation for the early-onset brain injuries in AGS and determined the signaling pathway underlying the neuropathogenesis. First, this mutation altered RNA editing profile in neural transcripts and led to robust IFN stimulated gene (ISG) expression in the brain. By in situ hybridization, the brain of mutant mice showed an unusual multifocal increased expression of ISGs that was cell-type dependent. An early onset astrocytosis and microgliosis, and later stage calcification in the deep white matter areas were observed in the mutant mice. Brain ISG activation and neuroglial reaction were completely prevented in the D1113H ADAR1 mutant mice by blocking RNA-sensing through deletion of the cytosolic RNA receptor MDA-5.Conclusions:The D1113H ADAR1 mutation causes RNA editing alteration in the brain, activating MDA5-dependent RNA sensing pathway activation and ISG expression, leading to the early-onset brain pathogenesis of AGS.