bluuebunny/crossref_metadata_2025_split huggingface dataset:
FATORES DE PATOGENICIDADE DE Yersinia enterocolitica
Authors: Rosin da Silva Júlia , Rodrigues Silveira Débora , Dias Timm Cláudio 
Published: October 2022

Yersinia enterocolitica é um patógeno causador de Doenças Transmitidas por Alimentos (DTA) envolvido em casos de toxi-infecções alimentares em humanos. Os sinais clínicos relacionados a yersiniose resultam em gastroenterite aguda, que cursa com febre, dor abdominal e diarreia. Y. enterocolitica apresenta seis diferentes biotipos (1A, 1B, 2, 3, 4 e 5). O biotipo 1B é considerado altamente patogênico, enquanto os biotipos 2 e 5 possuem patogenicidade baixa a moderada. Y. enterocolitica também pode ser classificada sorologicamente em mais de 70 sorotipos. Para ocorrer a infecção por essa bactéria é necessária a presença do gene ail, bem como do gene inv. O gene ail está relacionado à adesão e invasão de células do hospedeiro, já o gene inv é o principal gene envolvido na invasão dessas células. O presente estudo teve como objetivo realizar uma revisão de literatura a fim de sintetizar o conhecimento disponível a respeito dos fatores de patogenicidade de Y. enterocolitica, tendo em vista a importância deste gênero bacteriano na saúde pública.
Penguatan Literasi Sains Siswa MI/SD melalui Pengembangan E-Modul dengan Instrumen Asesmen berbasis Higher Order Thingking Skills
Authors: Herianingtyas Nur Luthfi Rizqa 
Published: October 2022

Tujuan dari penelitian ini adalah untuk mendeskripsikan pengembangan E-modul Literasi dan Numerasi dengan Instrumen Asesmen Higher Order Thingking Skills untuk Siswa MI/SD. Penelitian ini menggunakan pendekatan pengembangan dengan metode Research and Development (R & D). Teknik pengumpulan data yang digunakan dalam penelitian ini adalah wawancara dan angket untuk mendapatkan informasi terkait kebutuhan di lapangan terhadap e-modul literasi sains. Data kualitatif yang diperoleh dari hasil wawancara dan angket dianalisis menggunakan teknik interactive analysis. Pengembangan E-Modul literasi sains dengan instrumen asesmen berbasis Higher Order Thingking Skills dikembangkan melalui tahapan: (1) Research and Information Collecting, mengkaji kebutuhan di lapangan guru madrasah khususnya guru kelas V (lima). (2) Planning, Perencanaan pengembangan produk dilakukan oleh peneliti dengan membuat kerangka modul, pemilihan media website yang akan digunakan, serta pengembangan asemen HOTS (3) Develop Preliminary Product, pada tahap ini dikembangkan e-modul literasi sains bagian modul meliputi bagian awal, bagian isi, bagian akhir.
Drill Intensity and Head Impact Exposure in Adolescent Football
Authors: Kercher Kyle A. , Steinfeldt Jesse A. , Macy Jonathan T. , Seo Dong-Chul , Kawata Keisuke 
Published: October 2022

BACKGROUND AND OBJECTIVESThe objective of this study was to examine head-impact exposure by intensity level and position group, and to test the hypothesis that there would be an increase in cumulative head-impact exposure between drill intensities after controlling for duration in each level with air recording the lowest frequency and magnitude and live recording the highest: air &lt; bags &lt; control &lt; thud &lt; live.METHODSWe conducted a prospective, multisite study in 1 season with players from 3 high school football teams (n = 74). Each player wore a sensor-installed mouthguard, which monitored head-impact frequency, peak linear acceleration (PLA), and peak rotational acceleration (PRA). Practice drills and games were categorized by level of contact.RESULTSA total of 7312 impacts were recorded with a median of 67 (interquartile range:128) impacts per player. After controlling for duration, increases in head-impact outcomes by level of contact were observed (air &lt; bags = control &lt; thud = live). Live drills had higher cumulative head-impact frequency (45.4 ± 53.0 hits) and magnitude (PLA: 766.3 ± 932.9 g; PRA: 48.9 ± 61.3 kilorad/s2) per player than other levels (P &lt; .0001). In comparison, air drills had the lowest cumulative frequency (4.2 ± 6.9 hits) and magnitude (PLA: 68.0 ± 121.6 g; PRA: 6.4 ± 13.2 kilorad/s2).CONCLUSIONSThese data support the levels-of-contact system as a practical approach to limiting head-impact exposure in tackle football. Our findings are clinically important, because data have begun to suggest the relationship between chronic head-impact exposure and decline in brain health. Since head-impact exposure was influenced by levels of contact, regulation of the duration of certain drill intensities (eg, thud, live) may associate with reduced head-impact exposure in high school football.
The first occurrence of the family Homotomidae (Hemiptera: Psylloidea) and Homotoma ficus (Linnaeus, 1758) in Hungary
Authors: Fazekas Imre , Kontschán Jenő , Ripka Géza 
Published: October 2022

AbstractThe first author observed Homotoma ficus (Linnaeus, 1758) larvae on several street and garden fig trees in the city of Pécs in southern Hungary at the end of May 2022. In the first week of June 2022, imagoes were already flying. This is the first observation of this species in Hungary, together with the first report of the family Homotomidae. A diagnosis and illustrations of adults and larvae in Hungary with 21 figures are given.
AGR fuel corrosion: SIMFUEL-based method development in preparation for electrochemical studies of real spent AGR nuclear fuel electrode
Authors: Huang Yifeng , Boxall Colin , Hambley David , Wilbraham Richard 
Published: October 2022

AbstractElectrochemical corrosion of lower-activity spent fuel simulants, SIMFUELs, has been investigated in support of on-going analogous studies of a real AGR spent nuclear fuel electrode. Two electrode coupling methods have been investigated, to study the coupling of a sample of 25 GWd/tU SIMFUEL pellet to a sample of 20/25/Nb AGR cladding to replicate the real AGR fuel electrode setup. Method-1 involves coupling of individual standalone electrodes, while Method-2 involves coupling of the cladding and SIMFUEL within the same electrode. For both coupling methods, open circuit potentials and linear sweep voltammetry measurements were conducted in electrolyte solutions containing 30 μmol/m3 NaCl, dosed with NaOH to pH 8, 11.4 and 12.5. Resultant data were compared with single-component studies of SIMFUEL and cladding electrodes. Method-1 presents inconsistent electrochemical behaviour which we attribute to pitting/crevice corrosion effects on the cladding, whereas Method-2 shows a consistent behaviour that most resembles that of the SIMFUEL component.
Graphical abstract
Tierra. Mención / Mention
Authors: Farje Alcides , Gutiérrez María-Eugenia , Hurtado Ana , Pineño Esperanza , Rodríguez Rafael 
Published: October 2022

En la tierra se moldea un cuenco que se derrama por la pendiente. Es la disposición natural en el terreno para la reunión en torno a una persona. La base del cuenco es lugar para una comunicación más íntima y recogida con Dios. La doble piel protege del exterior sin perder la sensación de amplitud a cielo abierto. Mantiene· la luz natural de forma tamizada. Delimita el espacio para ser punto de estancia, no plano de movimiento
El cuenco se abre al paisaje a través del altar. Allí nace una galería adyacente a la iglesia que conecta con la- sacristía y las dependencias del edificio anejo. Ar pie de la iglesia queda el complejo residencial. las habitaciones frente al paisaje, comunicadas por un espacio cavernoso de luz indirecta.
TRANSITION TO SUSTAINABILITY: AN EMPIRICAL ANALYSIS OF FACTORS MOTIVATING INDUSTRIAL COMPANIES TO IMPLEMENT ESG PRACTICES
Authors: Lisovsky A. L. 
Published: October 2022

Currently, more and more companies follow the principles of sustainable development and implement ESG practices in corporate strategies. At the same time, a number of Russian companies experience barriers to implementing ESG practices and do not have the necessary competencies to build work on the implementation of sustainable development practices. In this context, it is important to understand the factors contributing to the implementation of ESG practices in Russian industrial companies.The research presented in the article is based on the data of a survey of 167 industrial companies. The results obtained allow us to speak about a variety of factors influencing the implementation of environmental, social and managerial initiatives. Thus, new technologies, consumer expectations, companies’ work on international markets, and regulatory requirements are the key factors in the implementation of environmental practices by industrial companies. Costs of current operations, the presence of a division and/or manager responsible for achieving sustainability goals, investment attractiveness, profitability of operations and operational efficiency improvements are drivers for the introduction of social practices by industrial companies. The implementation of management practices is most influenced by the factors of having units responsible for achieving sustainability goals, consumer expectations, companies’ performance in international markets, investment attractiveness and costs of current operations.The results of the study lead to conclusions about the need to create specialized units responsible for the implementation of sustainable development goals, to introduce new technologies, to pay attention to employee development and their social security in order to successfully achieve sustainable development goals.
KEY INDICATORS OF INNOVATION PERFORMANCE: PERCEPTION OF SIGNIFICANCE AND PRACTICAL APPLICATION
Authors: Trachuk A. V. , Linder N. V. 
Published: October 2022

This paper is devoted to the study of the correlation between the perceived significance of indicators of innovation activity and their actual use at enterprises of the Russian manufacturing industry. A sample of 132 manufacturing enterprises in Russia was used for the analysis. It was found that the recognition of the significance and the actual use of financial and non-financial indicators varies significantly depending on the affiliation of companies to a particular innovation regime: radical innovators, technological innovators, effective producers, creators of value innovations and imitators. Three key performance indicators (KPIs) reflecting the company's focus on the introduction of technological innovations (the share of modern equipment in the company's technology park (taking into account the technological features of industries); the average time to adapt the acquired innovative product, days; the share of implemented patents from the total number of patents received by the organization) were recognized as important managers of companies belonging to technological and radical innovators (74.5, 76.9, 78.1%, respectively). Three key performance indicators reflecting customer orientation (the number of new categories of products or services introduced in the reporting year; the share of products certified according to international standards in the total production of the company; the percentage of innovative expenditures on the modernization of existing products/processes/business models in relation to the total innovative expenditures on products/processes/business models) were recognized as important companies classified as effective producers and creators of value innovations (83.4, 81.9, 76.8%, respectively).But at the same time, the study showed that the most commonly used indicators are sales growth from new products (88.7%); the share of patents implemented (74.3%); total R&D expenses per 1 thousand dollars of revenue in the current reporting period (89.2%). In summary, conclusions are drawn about the actual application of key performance indicators of innovation activity by companies.
THE CONSUMER BEHAVIOR AND THE FORMATION OF VALUE IN THE RUSSIAN MARKET OF WINE PRODUCTS
Authors: Khachatryan A. A. 
Published: October 2022

The purpose of this article is to analyze consumer behavior and the formation of value proposition in the market of wine products. The analysis of sales of wine products, as well as the analysis of preferences in the choice of alcoholic beverages in Russia has been carried out. The analysis was based on a survey of 372 Russian consumers of wine products, as well as 47 wine companies from six Russian regions. The survey showed that the most valuable characteristics for wine producers and consumers are the following: taste and price, price-quality ratio, aesthetics (design and packaging), composition, brand, possibility to taste and country of production. At the same time, it is possible to distinguish a number of different features between the value for consumers and the formation of the value proposition wine companies and consumers distinguish. The results of this study were the conclusions that wine producers should consider in the formation of the value proposition: the appearance of packaging, product disclosure, discounts and promotions.
The role of sugammadex in endovascular interventions on cerebral vessels
Authors: Prasolov N. V. , Shulutko E. M. , Vasiliev A. E. , Gitelson D. G. 
Published: October 2022

Highlights. The article discusses the features of general anesthesia in patients with cerebrovascular diseases using the relaxant binding agent sugammadex.Aim. To evaluate the effectiveness of sugammadex in endovascular management of cerebrovascular diseases.Methods. The study included 57 patients who underwent endovascular treatment of cerebrovascular disease under general anesthesia. The experimental group included 29 patients who were injected with sugammadex - a selective relaxant binding agent for reversal of neuromuscular block induced by rocuronium. The comparison group included 28 patients who did not undergo decurarization (n = 13), or it was performed with neostigmine (n = 15). Acceleromyography was used to monitor the state of neuromuscular function.Result. Onset of action and duration of action of rocuronium at a dose of 0.9 mg/kg did not differ between the groups. The neuromuscular recovery time was 2.14 [1.67; 2.59] minutes after administration of sugammadex, compared with spontaneous 35.8 [31.5; 40.4] minutes and neostigmine-induced 22.1 [16.8; 27.3] minutes (p<0.001). No adverse or allergic reactions were noted after administration of the relaxant binding agent.Conclusion. Using a specific antidote sugammadex to eliminate the effect of rocuronium helps to restore neuromuscular function within 2–3 minutes and assess the neurological status of patients immediately after the endovascular treatment of cerebrovascular disease.
Non-invasive methods of <i>in vivo</i> functioning analysis of the “TiAra” stentless valve prosthesis
Authors: Onishchenko P. S. , Klyshnikov K. Yu. , Ovcharenko E. A. , Stasev A. N. , Kokov A. N. , Brel N. K. , Yevtushenko A. V. , Barbarash L. S. 
Published: October 2022

Highlights. Non-invasive method for the assessment of the mobility and deformation of the wire element of the bioprosthesis in the cardiac cycle based on the developed mathematical algorithm is presented. Numerical analysis of the behavior of the wire element of the “TiAra” bioprosthesis is shown for the first time. The developed method can be used for other medical devices as well.Aim. To develop a method for non-invasive assessment of the mobility and deformation of the wire element of the aortic heart valve bioprosthesis in the cardiac cycle based on mathematical processing of visual medical data.Methods. Multidetector computed tomography data of patient P. (male, 66 years old), who received the “TiAra” aortic bioprosthesis (NeoCor CJSC, Kemerovo), were used for the study. Using the built-in tools in the Mimics Medical Image Processing Software (Materialize, Belgium), based on the radio density, 5 stages of movement of the wire element of the bioprosthesis were reconstructed in the form of 3D-models. The differences between the models, characterizing deformation in the cardiac cycle, were quantitatively assessed using a proprietary Matlab algorithm (The MathWorks, USA), calculating the distance between similar points. Moreover, obtained data on displacements was used in the numerical study of the stress-strain state of a 3D-model of the wire element by the finite element method in the Abaqus/CAE software (Dassault Systèmes SE, France).Results. The proposed method for assessing the mobility of the wire element made it possible to quantitatively evaluate the biomechanics of the “TiAra” stentless bioprosthesis based on multidetector computed tomography, a non-invasive clinical tool. The movements that the bioprosthesis undergoes during the cardiac cycle (the maximum value is 2.04 mm in the radial direction) are comparable to the movement of the aortic root of a healthy patient. The results of the numerical modeling of the stress state of the wire element did not indicate high amplitudes (peak value – 564 MPa) that would be capable of causing critical damage to the wire. It allows us to confirm the clinical safety of the bioprosthesis in real conditions like asymmetric and uneven loads. Moreover, deformations observed in the bioprosthesis are similar in the amplitude to the displacements of the aortic root described in the literature, which highlights the main feature of the bioprosthesis – ensuring the physiological biomechanics throughout the cardiac cycle.Conclusion. The presented method of qualitative computer assessment of the movement of the wire element of heart valve prosthesis using the “TiAra” bioprosthesis as an example demonstrates its validity as a tool for studying prosthesis functioning.
Impact of <i>CYP2C19</i> gene polymorphisms on clinical outcomes in patients with myocardial infarction during 12-month follow-up
Authors: Grazhdankin I. O. , Baystrukov V. I. , Kretov E. I. , Prokhorikhin A. A. , Chernyavsky A. M. 
Published: October 2022

Highlights. CYP2C19 gene polymorphisms in patients with acute myocardial infarction are common in clinical practice. The article assesses the role of genetic predisposition in the development of ischemic and hemorrhagic events during dual antiplatelet therapy (aspirin and clopidogrel) within the first 12 months after revascularization for acute myocardial infarction.Aim. To evaluate the impact of CYP2C19 gene *1, *2, *3, *17 alleles polymorphism on 12-month clinical outcomes in patients who underwent coronary revascularization due to acute myocardial infarction and took clopidogrel.Methods. 363 patients with acute myocardial infarction undergoing percutaneous coronary intervention were enrolled in the prospectively study in 2010–2012. CYP2C19 gene *1, *2, *3, *17 alleles polymorphism analysis was performed in all study participants. Dual antiplatelet therapy, consisting of aspirin and clopidogrel, was prescribed for 12 months. The follow-up period was 12 months, the incidence of cardiovascular death, non-fatal myocardial infarction, stroke and bleeding was assessed.Results. 12 months after inclusion in the study, the incidence of composite endpoint (defined as cardiovascular death, non-fatal myocardial infarction and stroke) was observed in 18 patients (7% [5%; 11%]; 95% CI) with wild-type CYP2C19 gene and in 12 patients (11% [6%; 18%]; 95% CI) with lost-of-function *2+*3 alleles, with no statistical difference (OR = 1.6 [0.7; 3.6], 95% CI; p = 0.301). Presence of any LOF-alleles did not predict composite endpoint events (OR = 1.56 [0.71; 3.34], 95% CI, p<0.253). Multivariable logistic regression analysis revealed that CYP2C19*2 homozygotes have higher risk of composite endpoint (OR = 6.34, 95% CI [1.57; 22.23], p<0.005) and myocardial infarction (OR = 5.45, 95% CI [1.14; 19.97], p<0.016) compared to *2 heterozygotes and wild-type carriers. 14 patients had major bleedings, required blood transfusion or hospitalization. Patient’s age, increase in creatinine level and gain-of-function (GOF) CYP2C19*17 homozygotic carriage were identified as the predictors of major bleeding during follow-up period.Conclusion. In this study CYP2C19 LOF alleles polymorphism except the CYP2C19*2 homozygotic carriage demonstrated no impact on the incidence of ischemic events during 12-month follow-up in patients with acute MI who underwent successful revascularization. CYP2C19*17 homozygotes demonstrated increased risk of major bleeding only in young individuals with elevated blood creatinine levels.
Endovascular treatments for ischemic stroke
Authors: Malaev D. U. , Grachev N. I. , Redkin D. A. 
Published: October 2022

Highlights. Mechanical thrombectomy is the “gold standard” treatment of patients with large-vessel occlusions. Five randomized trials conducted in 2015 made a significant contribution to the development and introduction of mechanical thrombectomy into clinical practice. The DAWN and DEFUSE-3 trials have provided new insights into the pathophysiology of ischemic stroke and ensured the advancement in the therapeutic field.Abstract. Stroke is one of the leading causes of death and disability worldwide. The general strategy for the treatment of ischemic stroke is aimed at restoring blood flow to the ischemic regions of the brain. Intravenous thrombolysis has been the treatment for acute ischemic stroke since 1996. However, since 2015, as a result of 5 randomized trials, endovascular mechanical thrombectomy has become the gold standard for the treatment of patients with large cerebral artery occlusion. The DAWN and DEFUSE 3 trials have provided new insights into the pathophysiology of ischemic stroke, shifting the paradigm from “time = brain” to “collaterals = brain”. In this article, the authors will consider development of endovascular devices, modern mechanical thrombectomy techniques, and directions for further research of endovascular treatment for ischemic stroke.