bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arterial stiffness and blood pressure increase in pediatric kidney transplant recipients
Authors: Sugianto Rizky Indrameikha , Ostendorf Karen , Bauer Elena , von der Born Jeannine , Oh Jun , Kemper Markus J. , Buescher Rainer , Schmidt Bernhard M. W. , Memaran Nima , Melk Anette 
Published: September 2022

Abstract

Background
Pulse wave velocity (PWV) is a measure of arterial stiffness. We investigated PWV and blood pressure (BP) to determine to what extent BP changes contribute to arterial stiffness, and secondly, to identify influencing factors on BP in children after kidney transplantation.

Methods
Seventy children ≥ 2.5 years post-transplantation with at least two PWV measurements were included. Changes of systolic (Δ SBP) and diastolic BP (Δ DBP) were classified into “stable/decreasing,” “1–10 mmHg increase,” and “ > 10 mmHg increase.” Linear mixed modeling for PWV z-score (PWVz) adjusted either for Δ SBP or Δ DBP was performed. An extended dataset with monthly entries of BP, immunosuppression, and creatinine was obtained in 35 participants over a median of 74 months to perform linear mixed modeling for SBP and DBP.

Results
PWVz increased with a rate of 0.11/year (95% CI 0.054 to 0.16). Compared to participants with stable BP, those with 1–10-mmHg SBP and DBP increase showed a higher PWVz of 0.59 (95% CI 0.046 to 1.13) and 0.86 (95% CI 0.43 to 1.30), respectively. A > 10-mmHg BP increase was associated with an even higher PWVz (SBP β = 0.78, 95% CI 0.22 to 1.34; DBP β = 1.37, 95% CI 0.80 to 1.94). Female sex and participants with lower eGFR showed higher PWVz.
In the extended analysis, DBP was positively associated with cyclosporin A and everolimus trough levels.

Conclusions
A higher increase of PWV is seen in patients with greater BP increase, with higher cyclosporin A and everolimus trough levels associated with higher BP. This emphasizes the role of BP as a modifiable risk factor for the improvement of cardiovascular outcome after transplantation.

Graphical abstract
Impact of environmental factors on heat-associated mortalities in an urban desert region
Authors: Braun Rachel A. , Hondula David M. , Fraser Matthew P. 
Published: September 2022

Abstract
The troubling trend of rising heat-associated mortalities in an urban desert region (Maricopa County, AZ, USA) has motivated us to explore the extent to which environmental factors may contribute to increased heat-health risks. Summertime data from 2010 to 2019 were used to construct a suite of models for daily heat-associated mortalities. The best-performing full model included the following predictors, ordered from strongest to weakest influence: daily average air temperature, average of previous 5 days daily average air temperature, year, day of year, average of previous 5 days daily average dew point temperature, average of previous 5 days daily average PM2.5, and daily average PM10. This full model exhibited a 5.39% reduction in mean absolute error in daily heat-associated mortalities as compared to the best-performing model that included only air temperature as an environmental predictor. The extent to which issued and modeled excessive heat warnings (from both the temperature only and full models) corresponded with heat-associated mortalities was also examined. Model hindcasts for 2020 and 2021 showed that the models were able to capture the high number of heat-associated mortalities in 2020, but greatly undercounted the highest yet observed number of heat-associated mortalities in 2021. Results from this study lend insights into environmental factors corresponding to an increased number of heat-associated mortalities and can be used for informing strategies towards reducing heat-health risks. However, as the best-performing model was unable to fully capture the observed number of heat-associated mortalities, continued scrutiny of both environmental and non-environmental factors affecting these observations is needed.
Functional outcomes, extent of resection, and bright/vague fluorescence interface in resection of glioblastomas involving the motor pathways assisted by 5-ALA
Authors: Muscas Giovanni , Orlandini Simone , Bonaudo Camilla , Dardo Maddalena , Esposito Alice , Campagnaro Luca , Carrai Riccardo , Fainardi Enrico , Ciccarino Pietro , Della Puppa Alessandro 
Published: September 2022

Abstract
Background
5-Aminolevulinic acid (5-ALA) fluorescence can maximize perirolandic glioblastoma (GBM) resection with low rates of postoperative sequelae. Our purpose was to present the outcomes of our experience and compare them with other literature reports to investigate the potential influence of different intraoperative monitoring strategies and to evaluate the role of intraoperative data on neurological and radiological outcomes in our series.

Methods
We retrospectively analyzed our prospectively collected database of GBM involving the motor pathways. Each patient underwent tumor exeresis with intraoperative 5-ALA fluorescence visualization. Our monitoring strategy was based on direct stimulation (DS), combined with cortical or transcranial MEPs. The radiological outcome was evaluated with CRET vs. residual tumor, and the neurological outcome as improved, unchanged, or worsened. We also performed a literature review to compare our results with state-of-the-art on the subject.

Results
Sixty-five patients were included. CRET was 63.1%, permanent postoperative impairment was 1.5%, and DS’s lowest motor threshold was 5 mA. In the literature, CRET was 25–73%, permanent postoperative impairment 3–16%, and DS lowest motor threshold was 1–3 mA. Our monitoring strategy identified a motor pathway in 60% of cases in faint fluorescent tissue, and its location in bright/faint fluorescence was predictive of CRET (p < 0.001). A preoperative motor deficit was associated with a worse clinical outcome (p < 0.001). Resection of bright fluorescent tissue was stopped in 26%, and fluorescence type of residual tumor was associated with higher CRET grades (p < 0.001).

Conclusions
Based on the data presented and the current literature, distinct monitoring strategies can achieve different onco-functional outcomes in 5-ALA-guided resection of a glioblastoma (GBM) motor pathway. Intraoperatively, functional and fluorescence data close to a bright/vague interface could be helpful to predict onco-functional outcomes.
The effect of repeated testing on judgement bias in domestic dogs (Canis familiaris)
Authors: Wilson Clara , Hall Nathan , Aviles-Rosa Edgar O. , Campbell Kerry , Arnott Gareth , Reeve Catherine 
Published: September 2022

AbstractJudgement bias paradigms are increasingly being used as a measure of affective state in dogs. Approach to an ambiguous stimulus is commonly used as a measure of affect, however, this may also be influenced by learning. This study directly measured the impact of learning on a commonly used judgement bias paradigm in the absence of an affective state manipulation. Dogs (N = 15) were tested on a judgement bias task across five sessions. The dogs’ latency to approach a bowl placed in one of three ambiguous locations between non-baited (negative) and baited (positive) locations was measured. Results show that session number had a significant effect on the dogs’ latencies to reach the ambiguous bowl locations, with post-hoc tests revealing that dogs were significantly slower to approach the locations as the number of sessions increased. Session number also had a significant effect on the number of times the dogs did not approach the bowl within 30 s of being released, with the number of no approaches generally increasing across sessions. When dog identity was included as a fixed effect, a significant effect on latency to approach was found, suggesting that some dogs were consistently faster than others across sessions. To assess whether the paradigm produced repeatable results, Intraclass Correlation Coefficients were used. A low degree of reliability was found between latencies to approach each bowl position across sessions. This study demonstrates that dogs learned that the ambiguous locations were not rewarded with repeated exposures, and that this impacted their responses. We conclude that this judgement bias paradigm may require further consideration if applied across multiple exposures and that repeated results should be interpreted with caution as they are likely impacted by learning.
Risk factors for postoperative seizures in patients with chronic subdural haematomas
Authors: Kramer Andreas , Degenhartt Xenia , Gutenberg Angelika , Ringel Florian 
Published: September 2022

AbstractPostoperative seizures are a frequently occurring yet not well-understood complication in patients undergoing surgical treatment of chronic subdural haematomas (cSDHs). Therefore, we investigated surgical and non-surgical risk factors that are commonly considered causal in provoking epileptic seizures, paying special attention to the intracranial course of the subdural drain (SDD) and the configuration of the haematoma. Data of patients with a cSDH, that were treated at our neurosurgical department between 2008 and 2014 were analysed. Patients suffering from severe pre-existing conditions and those who have been treated conservatively were excluded. Epidemiologic data as well as relevant clinical data were collected. Pre- and postoperative CT scans were analysed regarding morpho- and volumetric parameters. In order to objectify the influence of the SDD, its intracranial course and localisation (entering angle as well as the angle between drain and brain surface) were measured. For statistical analysis, univariate and multiple logistic regression models as well as Fisher’s exact test were used. Two hundred eleven consecutive patients have been included. Mean age was 75.6 years, and 69% were male. Nineteen (9%) patients suffered from postsurgical seizures. Membranes within the haematoma were present in 81.5%. Pre- to postoperative haematoma reduction was significant (mean of difference − 12.76 mm/ − 9.47 mm in coronal/axial CT planes,p = 0.001/ < 0.001). In 77.9%, SDD showed cortical contact with eloquent regions and had an unfavourable course in 30 cases (14.2%). Surgical complications consisted of cortical bleeding in 2.5%, fresh subdural haematoma in 33.5% and wound infections in 1.4% of patients. Neither in univariate nor in multiple regression analyses any of the following independent variates was significantly correlated with postsurgical seizures: pre-existing epilepsy, alcohol abuse, right-sided haematomas, localization and thickness of haematoma, presence of septations, SDD-localization and to-brain angle, subdural air, and electrolyte levels. Instead, in multiple regression analyses, we found the risk of postsurgical seizures to be significantly correlated and increased with left-sided cSDH treated via craniotomy (p = 0.03) and an unfavourable course of the SDD in left-sided cSDH (p = 0.033). Burr hole trepanation should be preferred over craniotomy and care must be taken when placing a SDD to avoid irritating cortical tissue. The configuration of the haematoma does not appear to affect the postoperative seizure rate.
Mehr Anreize, weniger Sanktionen: Vorschlag für eine Reform der Grundsicherung
Authors: Breyer Friedrich 
Published: September 2022

ZusammenfassungDie Bundesregierung will das System der Grundsicherung für Arbeitsfähige radikal reformieren. Neben der Abschaffung des Vermittlungsvorrangs und der Stärkung der Qualifizierung will sie vor allem die Zuverdienstmöglichkeiten für Hilfeempfänger:innen verbessern. Fachleute zerbrechen sich schon lange den Kopf, wie die prohibitiv hohen Transferentzugsraten, also die Anrechnung von Markteinkommen auf den Transfer, auf ein erträgliches Maß gesenkt werden können, ohne dass das System zu teuer wird. Eine Lösung könnte in einer Variante des „Workfare“-Modells liegen, die aus einer Absenkung des Sockeltransfers und einer Arbeitsplatzgarantie des Staates besteht, sodass jeder Arbeitsfähige zur Deckung seines Grundbedarfs durch Arbeit beiträgt.
Umbruch bei der Eisenbahn in Deutschland?
Authors: Böttger Christian 
Published: September 2022

ZusammenfassungDie Politik hat der Eisenbahn eine wichtige Rolle bei der Senkung der Emissionen zugedacht. Aktuell zeigt sich allerdings, dass die DB AG als wichtigstes Unternehmen der Branche in Schwierigkeiten steckt. Die Zuverlässigkeit des Netzes sinkt dramatisch, sichtbar an abnehmender Pünktlichkeit und rückgestauten Güterzügen. Zugleich ist die wirtschaftliche Lage kritisch. Verkehrsminister V. Wissing hat Ende Juni 2022 angekündigt, die DB AG künftig stärker zu beaufsichtigen. Daraufhin trat der Aufsichtsratsvorsitzende, M. Odenwald, zurück. Die Probleme des Sektors und Lösungsansätze werden diskutiert.
Kohleausstieg 2030 unter neuen Vorzeichen
Authors: Egerer Jonas , Grimm Veronika , Lang Lukas M. , Pfefferer Ulrike 
Published: September 2022

ZusammenfassungDer russische Angriff auf die Ukraine und die Abhängigkeit der deutschen Energiewirtschaft von russischem Gas führen aktuell zu einer sehr angespannten Versorgungssituation, die sich im kommenden Winter noch verschärfen könnte. Auch mittelfristig dürfte der Importpreis für Erdgas deutlich oberhalb der historischen Werte liegen, wenn Europa sich von Russland unabhängig aufstellt. Diese Entwicklungen erfordern eine Neubewertung der deutschen Energiepolitik, unter anderem für die Energiewende im Stromsektor.
Factors Associated with Short and Long Term Mobility and HIV Risk of Women Living in Fishing Communities Around Lake Victoria in Kenya, Tanzania, and Uganda: A Cross Sectional Survey
Authors: Bahemuka Ubaldo M. , Okimat Paul , Webb Emily L. , Seeley Janet , Ssetaala Ali , Okech Brenda , Oketch Bertha , Kibengo Freddie M. , Okello Elialilia , Kwena Zachary , Kuteesa Monica O. , Price Matt A. , Kaleebu Pontiano , Grosskurth Heiner , Fast Pat ,   LVCHR
Published: September 2022

AbstractMobility is linked to negative HIV care continuum outcomes. We sought to understand factors associated with short and long term mobility among women in fishing communities in Kenya, Tanzania, and Uganda. From 2018 through 2019 we conducted a cross-sectional survey of women aged 15 years and above, randomly selected from a census of six fishing villages, around Lake Victoria. Data collected included: demographics, risky sexual behaviour on the most recent trip, and travel behaviour in the previous 4 months. Mobility was recorded as any overnight trip outside the participant’s village. A two-level multinomial logistic regression model was used to determine the associated factors. A total of 901 participants were enrolled, of whom 645 (71.6%) reported travelling (53.4%; short and 18.2% long term trips). Five factors were associated with long term travel: age, travel purpose, frequency of travel, sexual behaviour while travelling, and destination. Trips made by women aged 46–75 years were less likely to be long term. Long term trips were more common if the trip was to visit, rather than to trade, and more common for women who reported one or two trips rather than three or more trips. Women who made long term trips were more likely to engage in unprotected sex while on a trip. Women who travelled to a regional town/district or another town/district were more likely to take long term trips. The factors associated with travel duration among women living in fishing communities could inform planning of future health care interventions in these communities.
Two Types of Refutation in Philosophical Argumentation
Authors: Dutilh Novaes Catarina 
Published: September 2022

AbstractIn this paper, I highlight the significance of practices of refutation in philosophical inquiry, that is, practices of showing that a claim, person or theory is wrong. I present and contrast two prominent approaches to philosophical refutation: refutation in ancient Greek dialectic (elenchus), in its Socratic variant as described in Plato’s dialogues, and as described in Aristotle’s logical texts; and the practice of providing counterexamples to putative definitions familiar from twentieth century analytic philosophy, focusing on the so-called Gettier problem. Moreover, I discuss Lakatos’ method of proofs and refutations, as it offers insightful observations on the dynamics between arguments, refutations, and counterexamples. Overall, I argue that dialectic, in particular in its Socratic variant, is especially suitable for the philosophical purpose of questioning the obvious, as it invites reflection on one’s own doxastic commitments and on the tensions and inconsistencies within one’s set of beliefs. By contrast, the counterexample-based approach to philosophical refutation can give rise to philosophical theorizing that is overly focused on hairsplitting disputes, thus becoming alienated from the relevant human experiences. Insofar as philosophical inquiry treads the fine line between questioning the obvious while still seeking to say something significant about human experiences, perhaps a certain amount of what Lakatos describes as ‘monster-barring’—a rejection of overly fanciful, artificial putative counterexamples—has its place in philosophical argumentation.
Compiling CNNs with Cain: focal-plane processing for robot navigation
Authors: Stow Edward , Ahsan Abrar , Li Yingying , Babaei Ali , Murai Riku , Saeedi Sajad , Kelly Paul H. J. 
Published: September 2022

AbstractFocal-plane Sensor-processors (FPSPs) are a camera technology that enables low power, high frame rate computation in the image sensor itself, making them suitable for edge computation. To fit into the sensor array, FPSPs are highly resource-constrained, with limited instruction set and few registers - which makes developing complex algorithms difficult. In this work, we present Cain, a compiler for convolutional filters that targets SCAMP-5, a general-purpose FPSP. Cain generates code to evaluate multiple convolutional kernels at the same time. It generates code that avoids the need for hardware multipliers, while orchestrating the exploitation of common sub-terms—leading to a large reduction in instruction count compared to both straightforward and prior optimized approaches. We demonstrate the capability enabled by Cain on SCAMP-5 with robotic navigation for near-sensor high-speed and low-power computation, by using Cain to implement a neural network on the focal plane.
Dual HER2 blockade with pertuzumab (P) and trastuzumab (T) in patients with HER2-positive metastatic breast cancer (mBC) relapsing after adjuvant treatment with T: results from a German non-interventional study (NIS) HELENA (NCT01777958)
Authors: Thill Marc , Wimberger Pauline , Grafe Andrea , Klare Peter , Luedtke-Heckenkamp Kerstin , Reichert Dietmar , Zaiss Matthias , Ziegler-Löhr Katja , Eckl Tanja , Schneeweiss Andreas 
Published: September 2022

Abstract
Purpose
NIS HELENA documented outcomes in clinical routine practice of first-line therapy with P plus T and docetaxel (D) of patients with advanced HER2-positive BC and prior (neo)adjuvant T.

Methods
Between 06/2013 through 07/2016, 126 patients (in-label use of P at study start = full analysis set, FAS) in 81 German study sites were included. Intense documentation period was limited to 28 treatment cycles. Maximum follow-up (FU) was 24 months (mos). Safety was assessed in the safety set (SAF = eligible patients with at least one dose of P, n = 132). Median progression-free survival (PFS) was the main parameter of interest.

Results
Mean age of FAS patients was 55.1 [30.7–80.2] years, 81.7% (95.2%) were < 65 (75) years of age. 51.6% of the FAS patients were hormone receptor-positive (HR+), 91.3% had distant, 73.0% visceral, and 18.3% non-visceral metastases. Median disease-free interval was 40.2 [6.6–95.9] mos. Effectiveness (FAS): Median PFS was 18.8 [15.1; 24.2] mos. Overall response rate was 64.3% (55.6; 72.1). Median overall survival was 55.9 mos [41.2, not reached]. Safety (SAF): 93.9% of patients had an adverse event (AE), 32.6% a serious AE (SAE). AEs related to P occurred in 53.8% of SAF, SAEs related to P in 13.6%. Diarrhea was the most frequently reported related (S)AE. There were 8 (6.1%) patients with a fatal AE.

Conclusion
Based on the outcomes from NIS HELENA, results of dual blockade with P+T in patients relapsing after (neo)adjuvant T as reported from the CLEOPATRA study (NCT01777958) can be transferred to routine clinical practice. No new safety signals were detected.
Fullfield and extrafoveal visual evoked potentials in healthy eyes: reference data for a curved OLED display
Authors: Baumgarten Sabine , Hoberg Tabea , Lohmann Tibor , Mazinani Babac , Walter Peter , Koutsonas Antonis 
Published: September 2022

Abstract
Purpose
Visual evoked potentials (VEP) present an important diagnostic tool in various ophthalmologic and neurologic diseases. Quantitative response data varied among patients but are also dependent on the recording and stimulating equipment. We established VEP reference values for our setting which was recently modified by using a curved OLED display as visual stimulator. Distinction is made between fullfield (FF) and extrafoveal (EF) conduction, and the effect of sex, age and lens status was determined.

Methods
This prospective cross-sectional study included 162 healthy eyes of 162 test persons older than 10 years. A fullfield pattern-reversal visual evoked potential (FF-PR-VEP) with two stimulus sizes (ss) (20.4′ and 1.4°) as well as an extrafoveal pattern onset–offset VEP (EF-P-ON/OFF-VEP) (ss 1.4° and 2.8°) was derived in accordance with the International Society for Clinical Electrophysiology of Vision guidelines. Amplitudes and latencies were recorded, and the mean values as well as standard deviations were calculated. Age- and sex-dependent influences and the difference between phakic and pseudophakic eyes were examined. A subanalysis of EF-P-ON/OFF-VEP and fullfield pattern onset–offset VEP (FF-P-ON/OFF-VEP) was performed. A 55-inch curved OLED display (LG55EC930V, LG Electronics Inc., Seoul, South Korea) was used as visual stimulator.

Results
Mean P100 latency of the FF-PR-VEP was 103.81 ± 7.77 ms (ss 20.4′) and 102.58 ± 7.26 ms (ss 1.4°), and mean C2 latency of the EF-P-ON/OFF-VEP was 102.95 ± 11.84 ms (ss 1.4°) and 113.58 ± 9.87 ms (ss 2.8°). For all stimulation settings (FF-PR-VEP, EF-P-ON/OFF-VEP), a significant effect of age with longer latencies and smaller amplitudes in older subjects and higher amplitudes in women was observed. We saw no significant difference in latency or amplitude between phakic and pseudophakic eyes and between EF-P-ON/OFF-VEP and FF-P-ON/OFF-VEP.

Conclusions
A curved OLED visual stimulator is well suited to obtain VEP response curves with a reasonable interindividual variability. We found significant effects of age and gender in our responses but no effect of the lens status. EF-P-ON/OFF-VEP tends to show smaller amplitudes.
Job Prestige and Mobile Dating Success: A Field Experiment
Authors: Neyt Brecht , Baert Stijn , Vynckier Jana 
Published: September 2022

AbstractResearch using data on offline couple formation has confirmed predictions from evolutionary psychology that women (not men) attach value to the earnings potential of a potential partner. In this study, we examine whether the partner preferences with respect to earnings potential survive in an online context with fewer search and social frictions. We did this by means of a field experiment on the popular mobile dating app Tinder. Thirty-two fictitious Tinder profiles that randomly differed in job status and job prestige were evaluated by 4800 other, real Tinder users. We find that both men and women do not use job status or job prestige as a determinant of whom to show initial interest in on Tinder. However, we do find evidence that, after this initial phase, men less frequently start a conversation with women when those women are unemployed. Still, also then men do not care about the particular job prestige of employed women.