bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: A prospective observational study
Authors: Wu You , Sun Yunwei , Wu Yiwei , Zhang Kecheng , Chen Yan 
Published: August 2022

Abstract
Objective
To explore the predictive value of ferroptosis-related (FR) biomarkers for diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).
Methods
This prospective observational study enrolled patients with T2DM at the Second Hospital of Jilin University between December 2021 and March 2022. DKD was measured by the urinary albumin to creatinine ratio (UACR). Receiver operator characteristic curve (ROC) analysis were performed to assess the predictive value of ferroptosis-related biomarkers for DKD.
Results
Finally, 118 patients (53.0 ± 12.2 years, 76 males) were enrolled, 52 of them without DKD (had normal proteinuria), while 66 with DKD (41 had microproteinuria, and 25 had massive proteinuria). FR biomarkers, including acyl-coa synthase long chain family member 4 (ACSL4), malondialdehyde (MDA), and reactive oxygen species (ROS) were significantly higher in the massive proteinuria group than in the other groups, while glutathione peroxidase 4 (GPX4) was significantly lower (all P < 0.05). The area under the ROC of the combination of GPX4, ACSL4, MDA, and ROS for predicting DKD was 0.804 (P < 0.001). Additionally, multivariate logistic regression analysis showed that the course of disease and ferritin levels were independent risk factors for massive proteinuria, while high serum iron, transferrin, and GPX4 levels were independent protective factors for massive proteinuria in patients with T2DM (all P < 0.05).
Conclusion
The GPX4, ACSL4, MDA, and ROS combination might have a good predictive value for DKD. Additionally, the course of disease, ferritin levels, serum iron, transferrin, GPX4 were independently associated with massive proteinuria.
A promising antibacterial wound dressing made of electrospun Poly (Glycerol Sebacate) / Gelatin with local delivery of Ascorbic Acid and Pantothenic Acid
Authors: Kermani Pariya Khaloo , Kharazi Anousheh Zargar 
Published: August 2022

Abstract
Wounds can be caused by cuts, burns, surgeries, illnesses or accidents. The wound healing process can be disrupted by improper treatment conditions. The use of wound dressings has been the best treatment for chronic wounds. In this study, first, Poly (Glycerol Sebacate) was synthesized; then Poly (Glycerol Sebacate)-gelatin copolymer wound dressing containing vitamin B5 was made by electrospinning method. The membrane was crosslinked in the EDC/NHS solution and then loaded with vitamin C. The results indicated passage of water vapor, hydrophilicity and water absorption in samples with vitamins were ideal for wound healing process and absorption exude at wound site. On the other site, the degradation process showed the wound dressing stable during 14 days. As the following, the vitamin C and vitamin B5 release demonstrated burst release during 1 and 6 hours, respectively. Antibacterial results showed the presence of vitamin B5 in PGS/gelatin wound dressing can prevent the gram-negative and gram-positive bacteria growth. According cell viability assay, Vitamin C enhanced cell adhesion and cell proliferation. Finally, the PGS/gelatin with vitamin C/ vitamin B5 wound dressing with ideal biological properties recommend as a suitable wound healing product.
Helicobacter pylori infection upregulates miR-135b-5p to stimulate gastric cancer cell proliferation and inhibit cell apoptosis through activated IL-6/STAT3 signaling
Authors: Fang Rui , Shao Linlin , Zhou Anni , Li Xiao , Zhao Guiping , Qiao Chen , Zhang Nan , Zhang Shutian , Li Peng 
Published: August 2022

Abstract
Background
Helicobacter pylori (H. pylori) infection is a strong pathogenic factor of gastric cancer (GC). The dysregulation of microRNAs (miRNAs) has been correlated with gastric tumorigenesis, but their role in H. pylori-induced GC remains inadequately evaluated.
Methods
In situ hybridization was performed for evaluation of miR-135b-5p expression in GC patients. MTS assay, EdU cell imaging assay, live cell imaging and flow cytometric analysis were achieved for functional assessment of miR-135b-5p. Quantitative real-time PCR, western blot, chromatin immunoprecipitation, luciferase reporter assay and immunohistochemistry were used for exploration of regulatory mechanism and identification of target gene.
Results
Our study indicated that miR-135b-5p expression was increased in GC patients, and overexpression of miR-135b-5p stimulated GC cells proliferation and inhibits cell apoptosis. Mechanistically, H. pylori infection increased miR-135b-5p expression through the activation of the IL-6/STAT3 signaling, and STAT3 regulates miR-135b-5p via binding to its promoter directly. Furthermore, miR-135b-5p promoted GC progression by interfering TXNIP 3’ untranslated region and suppressing its protein expression, thereby affecting AKT phosphorylation. Expression of TXNIP was decreased in GC patients, and low expression levels of TXNIP in human GC patients is correlated with poor survival.
Conclusions
Our findings revealed a mechanism that H. pylori infection stimulates upregulation of miR-135b-5p via IL-6/STAT3 signaling and promotes gastric carcinogenesis, which brings up a promising diagnostic biomarker and provides an insight into therapeutic strategies for H. pylori-associated GC.
Liquefaction resistance of partially saturated sands
Authors: Zeybek Abdülhakim 
Published: August 2022

Abstract
Partially saturated sands with occluded gas bubbles may occur naturally in the field or can be created artificially as a way of mitigating liquefaction effects. The gas bubbles in pore spaces significantly alter the bulk modulus of pore fluid and consequently affect the excess pore pressure generation and liquefaction behavior of sands. This study aims to investigate the main parameters influencing the liquefaction resistance of partially saturated sands containing occluded gas bubbles. It also adopts a simplified approach and proposes empirical relationships linking liquefaction resistance ratio to bulk modulus, maximum volumetric strain, and excess pore pressure ratio. Considering these objectives, a total of 60 stress-controlled dynamic triaxial tests were conducted. Nearly/fully saturated and partially saturated sand specimens, prepared using sodium percarbonate, were subjected to undrained cyclic loading with a loading frequency of 0.1 Hz. The loosely or densely packed sand specimens at different degrees of saturation (79-100%) were examined under different initial effective confining stresses (25-100 kPa) and back pressures (100-400 kPa). The analysis of the test results indicated that the liquefaction resistance of partially saturated sands constantly increases as the degree of saturation decreases, and this effect is more prominent under higher initial effective confining stresses and lower back pressures. The adopted method satisfactorily captures this trend, showing reasonable matches between the empirical predictions and experimentally observed results from this study and previous research.
Magnitude of Malaria and Associated Factors Among Febrile Patients Visiting Public Health Facilities in Olanchity Town, East Shewa, Central Ethiopia, 2022. Crosssectional Study Design.
Authors: Gudeta Yosef , Daniel Radiet , Aman Duret 
Published: August 2022

Abstract
Background: Mortality and Morbidity caused by malaria is a major public health problem in developing countries like Ethiopia. Despite efforts to reduce its impact on community, the disease is still a projecting health problem in Ethiopia. In the study area, there is no study done that indicated extent of malaria and predisposing factors related as far as our knowledge concerned. This study, therefore, was undertaken to assess the magnitude of malaria and associated factors among febrile patient visiting public health facilities in Olanchit Town.Objectives: to assess the magnitude of malaria and associated factors among febrile patients visiting public health facilities in Olanchit Town, East Shewa, Central Ethiopia.Methods: Institution based cross sectional study was conducted from April 1st - June 30th, 2022. Every other febrile patient from all patients visiting the health facilities during the data collection period were interviewed using structured interviewer administered questionnaire. The collected data was coded, edited and entered in to Epi-Info version 7.1 and analyzed SPSS version 24. Descriptive statistics was performed to describe the magnitudes of malaria. Multiple logistic regression analysis was conducted to identify associated factors at 95% confidence interval and P -value <0.05 was used as cut-off points to declare significance in the final model.Result: in the study 306 respondents were involved making response rate 100%. Among febrile cases visited public health 85 (27.8%), (95% CI;17.0, 26.1) were positive for malaria cases and P. Vivax 43 (14.1%) were dominant species followed by mixed 26 (8.5%) and more cases 47 (15.4%) were observed in male. Malaria infection were associated with Sex who are male in gender (AOR = 5.7; 95% CI. 2. 74 – 16.1; P= 0.021), Age (AOR =7.7, 95% CI; 2.191 – 27. 321, P= 0.007), family members ever contracted malaria in their life (AOR = 3.7; 95% CI 1.469, 7.108; P = value 0.004).Conclusion and Recommendation: malaria cases found in this report was high when compared with strategies being followed now by MOH. To lower the prevalence of malaria infection there should be strong community mobilizer and active case search which might contribute to elimination goal that targeted clearing new and existing cases.
Correlates of substance use in a large naturalistic cohort of young people with early and emerging psychosis
Authors: El-Hage D. , Gao C. X. , Bedi G. , Guerin A. , Francey S. , Stavely H. , Rickwood D. , Telford N. , McGorry P. , Thompson A. , Brown Ellie 
Published: August 2022

Abstract
Background: Substance use remains a barrier to recovery for young people accessing early intervention services for psychosis. While correlates of use have been explored in populations experiencing a First Episode of Psychosis (FEP), sample sizes have been small and less research assesses cohorts at Ultra-High Risk of psychosis (UHR). Methods: This study uses data from a naturalistic cohort including UHR and FEP participants (N= 1252) to elucidate clinical correlates of use in the past three months of any illicit substance, amphetamine-type stimulants (ATS), cannabis, and tobacco. Moreover network analysis of these substances and additionally alcohol, cocaine, hallucinogens, sedatives, inhalants, and opioids was completed. Results: Young people with FEP used substances at significantly higher rates than those at UHR. High confluence of use was seen between substances. In the FEP group, participants who had used any illicit substance, ATS, and/or tobacco had increased positive symptoms and decreased negative symptoms. Young people with FEP who used cannabis had increased positive symptoms. In the UHR group participants who had used any illicit substance, ATS, and/or cannabis in the past 3 months showed decreased negative symptoms compared to those who had not. Conclusion: A distinct clinical picture of more florid positive symptoms and alleviated negative symptoms seen in those who use substances in the FEP group appears muted in the UHR cohort. Treating young people at UHR in early intervention services represents an opportunity to address substance use early in order to improve outcomes, particularly in those who go on to experience FEP.
A Prognostic Risk Score Based on Genes related with m 7 G regulators for the Prognosis and Immunotherapy Response of Lung Adenocarcinoma
Authors: Xia Ning , Nie Xiuhong , Wang Hao , Zhang Lin , Chen Yu 
Published: August 2022

Abstract
Background: Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer and is significantly correlated with poor prognosis. N7-methylguanosine (m7G) modification plays an important role in occurrence, progression, and prognosis of cancer. The present study aimed to construct a prognostic risk model based on m7G-related genes for LUAD. Methods: In this study, we used data from TCGA-LUAD for the training cohort and GSE72049 and GSE31210 for the validation cohorts. Univariate Cox regression, Lasso regression analyses, and multivariate Cox regression analyses were conducted to construct an m7G-related genes risk model. We then applied multivariate Cox regression, Kaplan-Meier analysis, and Receiver operating characteristic (ROC) curves to evaluate the risk model. Finally, we analyzed the immune microenvironment and immunotherapy response with the risk score model in LUAD.Results: A novel prognostic risk model based on the four m7G-related genes (ANLN, KRT6A, NTSR1 and RHOV) was constructed. The multivariate Cox analysis showed that the prognostic risk model was an independent risk factor (HR 1.224, 95% CI 1.162-1.290, P＜0.001). Patients in the high-risk group showed an increased risk of mortality in training cohort(HR 2.04, 95%CI 1.49-2.79, P＜0.001) and validation cohorts(HR 2.46, 95%CI 1.7-3.56; HR 3.85, 95%CI 1.98-7.49). The 1, 3, and 5-year AUC value in TCGA was 0.755, 0.71, and 0.631, respectively; The 1, 3, and 5-year AUC value in GSE72049 was 0.709, 0.672, and 0.762, respectively; The 1, 3, and 5-year AUC value in GSE31210 was 0.715, 0.649, and 0.709, respectively. The high-risk patients were more likely to respond to immunotherapy than the low-risk group(P＜0.001).Conclusion: A novel prognostic risk model based on m7G-related genes was established in this study, which may predict clinical prognosis and immunotherapeutic responses in LUAD patients.
Analysis of macro and micronutrient contents and spatial distribution for assessment at regional-scale: Case study Vushtrria region (Kosovo)
Authors: Shehu Ilir 
Published: August 2022

Abstract
Soil fertility determines crop growth productivity and consequently affects quality and sustainability. Thirty composite samples were taken, most in intensive cultivation and some in uncultivated soil. For soil analysis, classic and instrumental methods were used. Micronutrients in soil were measured by the ICP-OES method. Assessing contents, relationships between macro and micronutrients, and spatial distribution, were used methods descriptive statistics, Pearson correlation, Arcgis pro map, clusters, and PCA analyses. The physicochemical properties and potassium levels reflect the balanced distribution. Nitrogen (N) and Phosphorus (P) were at depleted levels. The kriging interpolation patterns showed uniform distribution of macronutrients, small changes were presented in uncultivated soil. Iron (Fe) and copper (Cu) showed acceptable balances, Nickel (Ni), Molybdenum (Mo), and Zinc (Zn) showed increased values compared to the New Dutch list and SEPA, while Boron (B) and selenium (Se) were at low content. PCA analysis and Dendrograms reflected the grouping of variables in one component resulting in the same source. Correlation analysis displays significant relationships between the parameters which were related to the inorganic component of the soil. Is recommended to add fertilizers, and micronutrients for balancing based on good practices and continuous monitoring.
Predictive value of frailty assessment tools in patients undergoing surgery for gastrointestinal cancer
Authors: Zhang Huipin , Zhang Hailin , Zhou Xiaomin , Chen Guanjie , Zhou Qifan , Tang Jie , Zhu Ziye , Wang Wei 
Published: August 2022

Abstract
Purpose
We used three commonly used frailty assessment tools to investigate the current status of preoperative frailty and to analyse their predictive value for prognosis in patients undergoing surgery for gastrointestinal cancer.
Methods
This single-centre, observational, prospective cohort study was conducted at the Affiliated Lianyungang Hospital of Xuzhou Medical University from August 2021 to July 2022. A total of 229 patients aged ≥ 18 years who underwent surgery for gastrointestinal cancer were included in this study. We collected the patients’ baseline data and used the Comprehensive Geriatric Assessment (CGA), Fried Phenotype (FP), and the FRAIL scale to assess frailty. The outcome measures were the complications experienced by patients and increased hospital costs.
Results
The prevalence of frailty was assessed using the CGA, FP, and FRAIL scale which returned the results 65.9%, 47.6%, and 34.9%, respectively. Multivariate logistic analysis confirmed that CGA was independently associated with increased hospital costs (OR = 2.514, 95% CI [1.202–5.258]; p = 0.014), and none of the frailty assessment tools were associated with total complications.
Conclusions
CGA was an independent predictor of increased hospital costs in patients undergoing surgery for gastrointestinal cancer.
Prediction for surface roughness of the large-pitch internal thread based on homologous isomerism data
Authors: Li Zhe , Qin Xiaobo , Fu Xiangfu , Jiang Bin , Cong Weiqi , Zhang Quanjian 
Published: August 2022

Abstract
For the problem of difficulty in measuring the surface roughness of large-pitch internal threads, predictions are used instead of measurements, whereas the common predictions are not highly accurate and narrow in scope of use. In this paper, the homologous isomerism data of vibration signal were utilized to establish a predictive model, which predicted the surface roughness of large-pitch internal threads. The corresponding homologous isomerism data were acquired by turning the large-pitch internal thread, and the data were processed using Relief-F algorithm to obtain the weights, which are the effects of different features on surface roughness. Additionally, influenced by the structural characteristics of the workpiece with a large pitch and a small number of teeth, support vector machine (SVM) and RBF neural network, which are suitable for researches with small sample sizes, from the machine learning algorithm were used to establish the predictive model with the homologous isomerism data of vibration signal as the input parameters. Eventually, the SVM model with higher accuracy of prediction and better ability of generalization was more appropriate for the research of this paper through comparison and analysis. The SVM model was verified to have absolute errors within 0.05μm and relative errors within 4% for turning both left and right threaded surface, demonstrating that the predictive model could take the place of measuring the surface roughness in the mass production of large-pitch internal threads. The method proposed in this paper can also be extended to other parts for the prediction of surface roughness, especially those whose surface roughness are difficult to measure due to structural characteristics.
Drivers of sex differences in the South African adult tuberculosis incidence and mortality trends, 1990-2019
Authors: Kubjane Mmamapudi , Cornell Morna , Osman Muhammad , Boulle Andrew , Johnson Leigh 
Published: August 2022

Abstract
Males have higher tuberculosis incidence and mortality rates than females. This study aimed to assess how sex differences in tuberculosis incidence and mortality could be explained by sex differences in HIV, antiretroviral treatment (ART) uptake, smoking, alcohol abuse, undernutrition, diabetes, social contact rates, health-seeking patterns, and treatment discontinuation. We developed an age-sex-stratified dynamic tuberculosis transmission model and calibrated it to South African data. We estimated male-to-female (M:F) tuberculosis incidence and mortality ratios, the effect of the abovementioned factors on the M:F ratios and population attributable fractions (PAFs) for the tuberculosis risk factors. Between 1990 and 2019, M:F ratios for tuberculosis incidence and mortality remained above 1.0, reaching 1.70 and 1.65, respectively in 2019. In 2019, HIV contributed to more significant increases in tuberculosis incidence among females than males (54.5% vs 45.6%); however, females experienced more reductions due to ART than males (38.3% vs 17.5%). PAFs for tuberculosis incidence due to alcohol abuse, smoking, and undernutrition, in males, were 51.4%, 29.5%, and 16.1%, respectively, higher than in females (30.1%, 15.4%, and 10.7%, respectively); the PAF due to diabetes was higher in females than males (22.9% vs 17.5%). Lower health-seeking rates in males accounted for a 7% higher mortality rate in men. The higher burden of tuberculosis in men highlights the need to improve men’s access to routine screening and ensure earlier diagnosis. Sustained efforts in providing ART is critical in reducing HIV-associated tuberculosis. Additional interventions to reduce alcohol abuse and tobacco smoking are also needed.
Micro-Kernels for Portable and Efficient Matrix Multiplication in Deep Learning
Authors: Alaejos Guillermo , Castelló Adrián , Martínez Héctor , Alonso-Jordá Pedro , Igual Francisco D. , Quintana-Ortí Enrique S. 
Published: August 2022

Abstract
We demonstrate that it is possible to rapidly assemble an amplevariety of high performance micro-kernels for the general matrix multiplica-tion (gemm) using vector intrinsics to exploit the SIMD (single instruction,multiple data) units in current general-purpose processors. For the particulartype of applications arising in deep learning, our experiments expose that theintrinsics-based micro-kernels can deliver efficiency on par with or even higherthan the conventional, carefully tuned implementations of gemm in currentlinear algebra libraries for ARM-based processors equipped with 128-bit SIMDunits and, to a lower extent, in processors with 512-bit SIMD units.
Water-Soluble Supramolecular Polymers Driven by Naphthalene- Naphthalene Interaction
Authors: Xue Weijian , Li Huiqian , Zhang Ying , Liu Yang , Zhao Bing , Guo Xiangfeng 
Published: August 2022

Abstract
Supramolecular polymers play a pivotal role in scientific and technological fields because of their inherent recyclability and their self-healing and stimuli-responsive properties. A water-soluble C-shaped receptors based on glycoluril and naphthalene building blocks is reported. The complexation formed in water was confirmed by 1H NMR spectroscopy and NOESY technique. 1H NMR spectroscopy, fluorescence spectroscopy and DLS measurements provide strong evidence that compound 2 undergoes self-recognition that naphthalene moiety can bind into the bisnaphthalene cleft and head-to-tail host–guest complexation to form a new supramolecular polymers in water. SEM and AFM visualized that the complexation formed the cyclic structure. This kind of highly designable monomer structure has great possibility to construct novel supramolecular polymer materials. Graphic abstract