bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cellular senescence preserves viral genome maintenance
Authors: Pham Alexander M , Ortiz Luz E , Lukacher Aron E , Kwun Hyun Jin 
Published: July 2022

AbstractSenescent cells accumulate in the host during the aging process and are associated with age-related pathogenesis, including cancer. Although persistent senescence seems to contribute to many aspects of cellular pathways and homeostasis, the role of senescence in virus-induced human cancer is not well understood. Merkel cell carcinoma (MCC) is an aggressive skin cancer induced by a life-long human infection of Merkel cell polyomavirus (MCPyV). Here, we show that MCPyV large T (LT) antigen expression in human skin fibroblasts causes a novel nucleolar stress response followed by p21-dependent senescence and senescence-associated secretory phenotypes (SASPs) which are required for MCPyV genome maintenance. The senolytic, navitoclax, treatment resulted in decreased senescence and MCPyV genome levels, suggesting a potential therapeutic for MCC prevention. Our results uncover the mechanism of a host stress response regulating human polyomavirus genome maintenance in viral persistency, which may lead to the targeted intervention for MCC.
A proteomic screen of Ty1 integrase partners identifies the protein kinase CK2 as a regulator of Ty1 retrotransposition
Authors: Barkova Anastasia , Adhya Indranil , Conesa Christine , Asif-Laidin Amna , Bonnet Amandine , Rabut Elise , Chagneau Carine , Lesage Pascale , Acker Joël 
Published: July 2022

AbstractBackgroundTransposable elements are ubiquitous and play a fundamental role in shaping genomes during evolution. Since excessive transposition can be mutagenic, mechanisms exist in the cells to keep these mobile elements under control. Although many cellular factors regulating the mobility of the retrovirus-like transposon Ty1 inSaccharomyces cerevisiaehave been identified in genetic screens, only very few of them interact physically with Ty1 integrase (IN).ResultsHere, we perform a proteomic screen to establish Ty1 IN interactome. Among the 265 potential interacting partners, we focus our study on the conserved CK2 kinase. We confirm the interaction between IN and CK2, demonstrate that IN is a substrate of CK2in vitroand identify the modified residues. We find that Ty1 IN is phosphorylatedin vivoand that these modifications are dependent in part on CK2. No significant change in Ty1 retromobility could be observed when we introduce phospho-ablative mutations that prevent IN phosphorylation by CK2in vitro. However, the absence of CK2 holoenzyme results in a strong stimulation of Ty1 retrotransposition, characterized by an increase in Ty1 mRNA and protein levels and a high accumulation of cDNA.ConclusionOur study highlights an important role of CK2 in the regulation of Ty1 retrotransposition. We provide the first evidence that Ty1 IN is post-translationally modifiedin vivo, as observed for retroviral INs, and demonstrate that CK2 strongly represses Ty1 mobility by inhibiting Ty1 transcription. The proteomic approach enabled the identification of many new Ty1 IN interacting partners, whose potential role in the control of Ty1 mobility will be interesting to study.
The temperature dimension of emotions
Authors: Bruno Pascal , Melnyk Valentyna , Murray Kyle B. 
Published: July 2022

Purpose
The literature to-date has focused on dimensions of emotions based on emotions’ affective state (captured by valence, arousal and dominance, PAD). However, it has ignored that emotional reactions also depend on emotions’ functionality in serving to solve recurrent adaptive problems related to survival and reproduction. Evolutionary psychology suggests that relationships with others are the key that helps individuals reach both goals. The purpose of this paper is to conceptualize, measure and validate the temperature dimension of emotions that underlies such human relationships, as suggested by frequent verbalization of emotional states via temperature-related terms (“cold fear” and “warm love”).

Design/methodology/approach
Across three studies (nStudy1a = 71; nStudy1b = 33; and nStudy2 = 317) based on samples from two countries (Germany and the USA) and using two different methods (semantic and visual), the temperature dimension of emotions is conceptualized and measured. Across a wide spectrum of emotions, factor analyses uncover temperature as an emotional dimension distinct from PAD and assess the dimension’s face, discriminant, convergent, nomological and criterion validity.

Findings
Emotional temperature is a bipolar dimension of an affective state that underlies human relationships, ranging from cold to warm, such that social closeness is linked to emotional warmth and social distance to emotional coldness. Emotional temperature is uncovered as a dimension distinct from PAD, that is, it is correlated with but separate from PAD.

Research limitations/implications
In this research, a portfolio of 17 basic emotions relevant in everyday consumption contexts was examined. Future research could further refine the emotional temperature dimension by analyzing more complex emotions and their position on the temperature map. In general, this paper sets the stage for additional work examining emotional temperature and its effects on consumer behavior.

Practical implications
The results have strategic implications for marketers on which emotions to select for campaigns, depending on factors like the climate or season.

Social implications
This research provides a better foundation upon which to understand the effect of emotions that invoke warmth or coldness.

Originality/value
To the best of the authors’ knowledge, this research is the first to conceptualize, measure and comprehensively validate the temperature dimension of emotions.
Universities’ built heritage as a means to diversify urban tourist destinations’ cultural supply: the case of the University of Porto
Authors: Leão Maria Teresa Gomes , Brandão Filipa Aguiar 
Published: July 2022

Purpose
This study aims to illustrate the potential of the many centuries-old universities buildings, in European cities, in a historical, architectural, aesthetic and symbolic dimension to diversify and differentiate urban tourist destinations supply.

Design/methodology/approach
This is a qualitative study supported by the analysis of public and classified documents, for which the main source is based on webography, and by conducting interviews.

Findings
The deficit of cultural tours, in the dimension of built heritage, is identified as one of the weaknesses of the city of Porto, as tourist destination, to be overcome. The interviewees are unanimous in recognizing the cultural, architectural and aesthetic impact of the historic buildings of the University of Porto, and most of them strongly agree with the integration of this legacy into the tourist offer of the city. The strategic sense of the heritage is emphasized, because of its location in charismatic areas of the city. The practice of effective networking, however, falls short of what is required to achieve ambitious and consistent objectives.

Research limitations/implications
The practice of effective networking, however, falls short of what is required to achieve ambitious and consistent objectives.

Originality/value
Emphasis is placed on the cities’ built heritage as a type of heritage that defines their uniqueness. The dissemination of cultural itineraries, which allows tourists and the community itself a broader and deeper cultural knowledge, contributes to the effective understanding of historic cities’ tourism. Given the scarcity of studies on the relationship between historic university buildings and tourism, the relevance of research focuses on highlighting the contribution of these cultural elements, through a network-based dynamic, to urban tourism destinations’ attractiveness. In particular, the University of Porto's potential for the integration of structured tourism products that contribute to the diversification and differentiation of the city of Porto as a destination is illustrated.
Sustainability performance at stake during COVID-19 pandemic? Evidence from Sharia-compliant companies in emerging markets
Authors: Hambali Ahmad , Adhariani Desi 
Published: July 2022

Purpose
This study aims to analyse whether Sharia-compliant companies have better sustainability performance, especially in the midst of the COVID-19 pandemic. The pandemic context is worth investigating as there is a concern that companies will reduce their sustainability activities to focus more on economic recovery, thereby leading to lower sustainability performance.

Design/methodology/approach
This study uses data from companies listed on Indonesian and Malaysian stock exchanges. These two countries have experienced rapid developments in Islamic finance and possess similar criteria in assigning the Sharia compliance label to a company. The data on sustainability performance and its three dimensions (environmental, social and governance) were gathered from Refinitiv (Thomson Reuters) and analysed using panel data regression.

Findings
The results show that Sharia-compliant companies had a higher sustainability performance in all research periods, but not during the COVID-19 pandemic. This implies that the pandemic has not triggered a need for Sharia-compliant companies to improve their sustainability performance. The results can be interpreted that sustainability performance is not only at stake during the COVID-19 pandemic but it can also indicate a “business-as-usual” approach applied by companies regardless of the Sharia-compliant label.

Originality/value
Sustainability performance has been intensively investigated in prior research, but how it is related to the current health crisis and Sharia compliance has been scantily studied and becomes the originality of this research.
An institutional approach on the effects of diversification type
Authors: Krug Juliano , Falaster Christian 
Published: July 2022

PurposeIn this study, the authors argue that there is more than meets the eye on the effects over postacquisition performance and diversification. This study aims to propose that the conditions that allow higher returns are dependent on the institutional context. The authors suggest that diversification strategies differ in their impact on postacquisition performance when moderated by the institutional inefficiencies of economies.Design/methodology/approachThis research is based on a quantitative approach. The authors statistically test the hypotheses based on multiple regression analysis.FindingsResults show a negative moderating effect of the institutional inefficiencies of the target country on the relationship between the diversification decisions of the firm and its postacquisition performance. So that Latin American firms that perform Cross-border acquisitions with higher degrees of diversification are related to worse performance. However, the degree of institutional inefficiencies negatively moderates this relation, attenuating the negative effects of diversification over performance.Originality/valueAlthough past research has shown that economies with high institutional inefficiencies can benefit from higher levels of diversification, no study has considered the impact of the institutional inefficiencies when discussing many economies, to authors’ acknowledgment. The authors provide evidence that, in the case of Latin American firms, diversification reduces performance; however, the degree of institutional inefficiencies negatively moderates this relation.
Social shopping at Goel Stores: forging ahead through the use of social media
Authors: Shukre Anagha , Verma Naresh 
Published: July 2022

Research methodology
The case study is based on field research and also on secondary data. A primary survey is included in the case study. Simple frequency and factor analysis as statistical tools have been used.

Case overview/synopsis
Family businesses, like that of Kiran Rai’s, owning a local Mom and Pop store in an emerging city were faced with a serious problem of sustaining their businesses. These family businesses countered immense competition from: their own types, i.e. from other local Mom and Pop stores within the same cities; online stores; and the organised stores.The choice of the customers to buy goods from the neighbourhood shops has remained largely as an age-old tradition in the households. With the millennials and the Generation Z (Gen Z) exposed to an array of brands, can they become the first choice of young customers for shopping for all kinds of products and varieties? Can the local Mom and Pop stores spread their wings across the young generations, particularly the Millennials and Gen Z through inexpensive social media channels? What are their growth options? How can the social media serve this purpose? The case uses the social cognition theory and the use gratification theory to throw light on the new concept of Social Shopping.

Complexity academic level
The case is meant to be discussed in courses like Fundamentals of Marketing, Digital Marketing and Retail Marketing in a 90-min session in the Post Graduate as well as in the Working Executives’ Management programmes. The case analysis will expose the students to the use of social media and its benefits to the small businesses. The students will also be able to analyse and understand the different types of Online Consumers’ Shopping Personalities. This would enable them to strategize for different stages in the decision-making processes.
Industrial tail exposure risk and asset price: Evidence from US REITs
Authors: Song Jeongseop , Liow Kim Hiang 
Published: July 2022

AbstractIn this study, we investigate the impact of industry‐based tail dependence risk on the cross‐section of stock returns. To this end, we propose a novel tail risk dependence measure (industrial tail exposure risk [ITER]), which captures the tail risk exposure of individual stocks to multiple industries. Using US equity real estate investment trusts (REITs) data from 1993 to 2020, we document that stocks in the highest ITER portfolio outperform stocks in the lowest ITER portfolio by 8.40% per annum. This positive return spread is significant even after controlling for well‐known firm characteristics. The return premium of ITER is stronger for small, value, and highly levered stocks and is substantially high during recession periods. Finally, the effects of ITER are cross‐sectionally more associated with REITs that have greater degrees of the following factors: bivariate tail exposure risks of major industries, exposure to local industry tail risk, geographical concentration, and ownership of home‐biased investors. Overall, our results suggest that REIT investors are indeed averse to tail risks that are associated with various sectors.
Conjunctive use of synchrotron X‐ray diffraction and Rietveld refinement in Fe‐oxide clays for forensic applications
Authors: Testoni Samara Alves , Prandel Luis Valerio , Melo Vander Freitas , Dawson Lorna Anne , da Silva Salvador Fábio Augusto 
Published: July 2022

AbstractSoils have distinctive chemical, physical, mineralogical and biological properties, which make it possible to differentiate them in different environments and also to test for an association of a particular questioned item with a crime scene. Mineral compositions and structures in the soil clay fraction can reflect a distinct characteristic when analyzed by powerful techniques. In this way, the aim of this study was to compare the discriminative power of Fe‐oxides concentrated clay samples from the same soil class with and without differences in parent material when analyzed using the Rietveld method and two sources of X‐ray diffraction: conventional and high‐resolution synchrotron radiations. Clay samples were Fe concentrated (kaolinite and gibbsite removal) to clarify mineralogical composition of 12 samples from three simulated crime scenes, developed under claystone and granite. By Rietveld refinement, detailed crystallographic data were obtained to discriminate samples according their provenance. By synchrotron radiation, mineral data demonstrated the power of quantitative (crystallite size and minerals contents) and qualitative (identification of majoritarian and accessory minerals) analysis by Rietveld refinement, which provides well‐resolved data able to discriminate samples from different and same geology. The techniques can be applied in other criminal investigations given their potential of discrimination.
Chlorella unsaturated fatty acids suppress high‐fat diet‐induced obesity in C57/BL6J mice
Authors: Yang Yang , Ge Shenhan , Chen Qingyan , Lin Shaoling , Zeng Shaoxiao , Tan Bee K. , Hu Jiamiao 
Published: July 2022

AbstractChlorella has been identified as a rich source of unsaturated fatty acids. Since the antiobesity effects of unsaturated fatty acids have been well documented; therefore, we explored the antiobesity actions of chlorella unsaturated fatty acids (C.UFAs) in the current study. The obtained results demonstrated C.UFAs, which contain abundant linoleic acid, could retard body weight gain (reducing body weigh by 13.93% after 16 weeks of treatment), improve blood glucose (19.29% lower) and lipid profile (23.45% lower in TG, 8.76% lower in TC) compared to high‐fat diet‐fed C57BL/6J mice. The possible underlying mechanisms might involve reducing hepatic lipid accumulation via down‐regulation of lipogenic genes (PPARγ, C/EBPα, LPL, aP2, FAS, and SREBP‐1c) and up‐regulation of lipolytic gene (adiponectin). We also demonstrate C.UFAs could reduce HFD‐induced adipocyte hypertrophy via activation of AMPK signaling pathway in adipose tissue and liver. In summary, our study highlights the potential of C.UFAs as a functional food for obesity management.Practical ApplicationChlorella has already been commercialized as a functional food antiobesity function. In the current study, the unsaturated fatty acids isolated from chlorella were found to exert beneficial effects on hyperglycemia, hyperlipidemia, hepatic steatosis, and adipocyte hypertrophy in high‐fat diet‐fed mice. This may provide theoretical foundation for developing novel chlorella‐based functional foods.
Dynamic 18F‐FDG PET/CT can predict the major pathological response to neoadjuvant immunotherapy in non‐small cell lung cancer
Authors: Chen Zhi‐Yong , Fu Rui , Tan Xiao‐Yue , Yan Li‐Xu , Tang Wen‐Fang , Qiu Zhen‐Bin , Qi Yi‐Fan , Li Yu‐Fa , Hou Qing‐Yi , Wu Yi‐Long , Zhong Wen‐Zhao , Jiang Ben‐Yuan 
Published: July 2022

AbstractMajor pathological response (MPR) is a potential surrogate for overall survival. We determined whether the dynamic changes in 18F‐labeled fluoro‐2‐deoxyglucose positron emission tomography/computed tomography (18F‐FDG PET/CT) were associated with MPR in patients receiving neoadjuvant immunotherapy. Forty‐four patients with stage II–III non‐small cell lung cancer (NSCLC) who received neoadjuvant immunotherapy and radical surgery were enrolled. Moreover, 18F‐FDG PET/CT scans were performed at baseline and within 1 week before surgery to evaluate the disease. All histological sections were reviewed to assess MPR. The detailed clinical features of the patients were analyzed. The reliability of the clinical variables was assessed in differentiating between MPR and non‐MPR using logistic regression. Receiver‐operating characteristic (ROC) curve analysis identified the SUVmax changes threshold most associated with MPR. Most of the patients were pathologically diagnosed with squamous cell carcinoma and received anti‐PD‐1 antibodies plus chemotherapy. The immunotherapy regimens included nivolumab, pembrolizumab, and camrelizumab. MPR was observed in more than half of lesions. Tumors with MPR had a higher decrease in the longest dimension on dynamic PET/CT than those without MPR. Furthermore, the decline in SUVmax was significantly different between MPR and non‐MPR diseases, and MPR lesions had a prominent mean reduction in SUVmax. SUVmax reduction was independently associated with MPR in the multivariate regression. On ROC analysis, the threshold of SUVmax decrease in 60% was associated with MPR. Dynamic changes in SUVmax were associated with MPR. The tumors with MPR showed a greater PET/CT response than those without MPR. A SUVmax decrease of more than 60% is more likely to result in an MPR after receiving neoadjuvant immunotherapy.
Non‐small cell lung cancer with tumor proportion score > 90% could increase the risk of severe immune‐related adverse events in first‐line treatments with immune checkpoint inhibitors: A retrospective single‐center study
Authors: Akazawa Yuki , Yoshikawa Aki , Kanazu Masaki , Yano Yukihiro , Yamaguchi Toshihiko , Mori Masahide 
Published: July 2022

AbstractBackgroundSince 2015, immune checkpoint inhibitors have been a clinical treatment strategy for patients with advanced or recurrent non‐small cell lung cancer (NSCLC). However, the relationship between immune‐related adverse event (irAE) risk factors and patient clinical characteristics is unclear. This study aimed to evaluate the relationship between irAE risk and the clinical characteristics of patients with NSCLC.MethodsWe included patients with advanced or recurrent NSCLC with known programmed death‐ligand 1 expression levels treated with immune checkpoint inhibitors. We retrospectively examined the medical records of 260 patients with NSCLC (March 2016–November 2020) and analyzed the relationship between the patient clinical characteristics and irAEs.ResultsOur retrospective analysis revealed that tumor proportion score (TPS) ≥ 90% and adenocarcinoma histology were independent risk factors for irAEs (odds ratio: 3.750 95% confidence interval [CI]: 1.58–8.89 and 0.424 95% CI: 0.19–0.97, respectively) in first‐line treatment. However, in patients receiving second‐ or later‐line treatments, no clinical characteristics were identified as risk factors for irAEs. Furthermore, no difference was observed in the response rates to first‐line treatments between the TPS ≥ 90% and TPS < 90% groups (74% vs. 71%, p = 0.83). In later‐line treatments, the TPS ≥ 90% group had a better response rate than the TPS < 90% group (55% vs. 17%, p < 0.05). However, no significant differences in overall survival were observed in either of the groups.ConclusionsTPS ≥ 90% and adenocarcinoma histology were independent risk factors for irAEs in previously untreated patients with advanced or recurrent NSCLC. Therefore, patients at high risk of irAEs require additional monitoring.