bluuebunny/crossref_metadata_2025_split huggingface dataset:
La cohérence dans les productions écrites des élèves en classe de langue étrangère (niveau B)
Authors: Zając Jolanta 
Published: May 2022

La production écrite est une de ces compétences qu’il est nécessaire de développer de manière particulièrement soignée et planifiée lors d’un cours de langue. Elle se forme avec beaucoup de peine et peut causer des déceptions et même une sorte de démotivation pour l’étude de la langue. Traditionnellement, l’écrit est considéré comme étant « difficile » à maîtriser, exigeant des connaissances qui ne sont pas accessibles à tout le monde ; peut-être même faudrait-il parler d’un certain « don » pour l’écriture faut duquel il serait inutile de se lancer dans cette aventure, car tout pourrait s’enseigner sauf ceci. Certes, apprendre à écrire, ou plutôt à communiquer par écrit n’est pas une évidence ni en langue maternelle ni, encore moins, en langue étrangère. Ce canal de communication pose des problèmes et impose des solutions mais ne laisse pas ceux qui désirent s’en servir sans aucune aide ni appui.
Pour ce faire, d’un côté apparaît la nécessité de connaître à fond les spécificités de la production écrite, en ayant recours aux informations fournies par la linguistique textuelle, par les sciences cognitives, par la génologie et, de l’autre, il s’agit d’examiner les possibilités de leur opérationnalisation en classe de langue.
Présentation
Authors: Singy Pascal , Bourquin Céline , Weber Orest 
Published: May 2022

COMME NOUS LE RAPPELLE le contenu d’un article paru dans le dernier numéro du Journal of Sociolinguistics, la communication entre cliniciens et patients est encore loin de se réaliser toujours et partout dans le plein respect de ce qu’il est convenu d’appeler la dignité des personnes. Certes, la question de la dignité des personnes interroge plusieurs aspects de la relation thérapeutique. Le fait de comprendre et d’être entendu constitue à l’évidence l’un d’entre eux. De ce point de vue, une part importante de la population migrante et allophone apparaît clairement désavantagée. On pense particulièrement aux migrants primo-arrivants qui fréquentent de manière importante – du moins en Europe et en Amérique du Nord – les structures de santé. Une fréquentation qui s’explique pour une large part par la situation de vulnérabilité que peuvent, par exemple, engendrer un statut administratif précaire, de faibles ressources socioéconomiques et des traumatismes vécus dans le pays d’origine.
Dans le monde médical, comme ailleurs, la réussite des échanges verbaux suppose un partage, d’une part, des codes communicationnels utilisés dans ces échanges et, d’autre part, d’un certain nombre d’implicites culturels permettant de décrypter correctement le sens plein de tel ou tel message. La notion de « barrière linguistique » est souvent convoquée pour rendre compte des situations de nonpartage ou de partage très limité de ces codes et implicites. Cependant, cette notion et les réalités qu’elle devrait recouvrir apparaissent encore trop peu problématisées.
Entre clinicien et patient : ce que la barrière linguistique empêche, ce qu’elle permet
Authors: Guerrero Omar 
Published: May 2022

LES « BARRIERES LINGUISTIQUES », FIL CONDUCTEUR du présent volume, se trouvent au cœur de la clinique du Centre de soins Primo Levi, à Paris. Son équipe est pluridisciplinaire : des médecins généralistes, des psychologues cliniciens qui sont psychanalystes, un assistant social, une juriste, une accueillante et une kinésithérapeute qui interviennent auprès des mêmes patients, articulant le savoir-faire de chaque spécialité avec les autres dans une visée thérapeutique.
Les patients accueillis au Centre de soins sont des personnes victimes de la torture et de la violence politique, ils les ont subies dans leurs pays d’origine. De ce fait, le traumatisme est souvent le déclencheur de la demande de soins, même s’il laisse la place à d’autres problématiques qui apparaissent plus tard, dans le déroulement du suivi. Il est important pour nous de souligner qu’il s’agit de « personnes victimes » et non pas « victimes », c’est l’un des piliers éthiques de notre travail : nous préférons utiliser « victimes » comme un adjectif, pour ne pas réduire ces personnes à un statut qui ne fut que ponctuel, qui ne les définit pas essentiellement. Certaines langues latines différencient d’ailleurs pour le verbe « être » ce qu’il en est de l’essence et ce qui concerne un état. En traitant ce statut de « victimes » comme un état, les cliniciens du Centre Primo Levi reconnaissent à ces personnes l’humanité que les bourreaux tentèrent de nier.
Dans ce contexte, un tiers des patients suivis au Centre ne peuvent pas s’exprimer en français. Certains intervenants parlent les langues locales des pays concernés, ou bien des langues tierces, comme l’anglais, qui permettent une relation thérapeutique « classique », à deux. Mais un quart des personnes qui consultent ne trouvent pas un clinicien qui parle leur langue ou une langue commune. C’est alors que nous faisons appel à des interprètes professionnels.
Quels sont alors les enjeux lorsque la traduction fait intervenir un tiers, incarné par l’interprète, dans l’intimité duelle de la relation thérapeutique ?
Présentation
Authors: Velmezova Ekaterina 
Published: May 2022

L’étude de l’histoire et de l’épistémologie des idées linguistiques constitue l’un des centres du travail de recherche actuellement mené par les linguistes de la partie slave de la Section de langues et civilisations slaves et de l’Asie du Sud de l’Université de Lausanne. Instaurée chez les slavistes lausannois par le professeur Patrick Sériot, cette direction de travail se poursuit toujours après son départ à la retraite en 2014.
En travaillant principalement sur l’histoire et l’épistémologie des sciences du langage en Europe centrale et orientale, nous collaborons avec des collègues qui étudient l’histoire de la linguistique dans d’autres régions et dans d’autres «traditions académiques»; ainsi, durant ces dernières années, de nombreux collègues historiens des idées linguistiques se sont arrêtés à Lausanne pour participer à nos colloques, à nos écoles doctorales, à nos cours et séminaires, ainsi que pour proposer leur expertise sur les travaux de nos étudiants et de nos doctorants ou pour discuter de projets de collaboration. La plupart des textes réunis dans ce recueil sont précisément les travaux présentés lors de ces rencontres
O góralach Kaukazu wybranych uwag kilka (1914-1924)
Authors: Lityński Adam 
Published: May 2022

Imperium Rosyjskie opanowało Kaukaz Północny w XIX wieku. Osiedlano tam głównie Kozaków. Miejscowa ludność wyznawała islam, co zbliżało ją do Persji oraz Imperium Osmańskiego. Po rewolucji 1917 r. w Rosji Kaukaz Północny był terenem walk sił „białych”, „czerwonych” oraz ludności miejscowej z Kozakami. Ostatecznie zwyciężyli bolszewicy i włączyli ten obszar do ZSRR.
Features of postoperative hearing function changes in patients with cerebellopontine angle and intratemporal tumors other than vestibular schwannomas
Authors: Ichimasu Norio , Kohno Michihiro , Nakajima Nobuyuki , Sakamoto Hiroki , Matsushima Ken , Yoshino Masanori , Tsukahara Kiyoaki 
Published: May 2022

OBJECTIVE
Tumors around the cerebellopontine angle (CPA) and temporal bone can potentially affect hearing function. In patients with such tumors other than vestibular schwannomas (VSs), auditory tests were investigated before and after surgery to characterize the auditory effect of each tumor and to determine prognostic factors.

METHODS
A total of 378 patients were retrospectively evaluated for hearing functions before and after surgery. These 378 patients included 168 with CPA meningioma, 40 with trigeminal schwannoma (TS), 55 with facial nerve schwannoma (FNS), 64 with jugular foramen schwannoma (JFS), and 51 with CPA epidermoid cyst (EPD).

RESULTS
Preoperative hearing loss was observed in 124 (33%) of the 378 patients. Of these 124 patients, 38 (31%) experienced postoperative hearing improvement. Postoperative hearing deterioration occurred in 67 (18%) of the 378 patients. The prognostic factors for postoperative hearing improvement were younger age and the retrocochlear type of preoperative hearing disturbance. Tumor extension into the internal auditory canal was correlated with preoperative hearing loss and postoperative hearing deterioration. Preoperative hearing loss was observed in patients with FNS (51%), JFS (42%), and MGM (37%), and postoperative hearing improvement was observed in patients with JFS (41%), MGM (31%), and FNS (21%). Postoperative hearing deterioration was observed in patients with FNS (27%), MGM (23%), and EPD (16%).

CONCLUSIONS
According to the results of this study in patients with CPA and intratemporal tumors other than VS, preoperative retrocochlear hearing disturbance was found to be a prognostic factor for hearing improvement after surgery. Among the tumor types, JFS and MGM had a particularly favorable hearing prognosis. The translabyrinthine approach and cochlear nerve section should be avoided for these tumors, regardless of the patient’s preoperative hearing level.
Synthesis, characterization of dialkylated erythrosin B derivatives and their utility as a propitious anti-microbial agent
Authors: Sandhu Navjot , Singh Atul Pratap , Pandey Satish K , Ghule Vikas D. , Tittal Ram Kumar , Yadav Rajesh Kumar , Shrivastava Rahul 
Published: May 2022

The development of small molecule based drugs as an antimicrobial agent is an important area of research nowadays. In the present work, two new molecular entities based on dialkylated erythrosin B has been synthesized via Arbuzov type of rearrangement using dialkyl sulphite as a reagent in the presence of Et3N. Ethyl and methyl based dialkylated derivatives of erythrosin B were characterized using 1H NMR, 13C NMR and HRMS data. Keeping in mind the biological safety of erythrosin B, synthesized derivatives were checked for their antimicrobial activity against the microbial strains Escherichia coli (E.coli). The two were found to be effective against the E. coli with the antimicrobial activity similar to that of Ampicillin. Further, the trend of antimicrobial activity has been supported by DFT data analysis and it was observed that compound, B with low HOMO (–5.93 eV) and LUMO (–3.11 eV) energies is a better antimicrobial agent than compound A.
Effect of Concomitant Use of Analgesics on Prognosis in Patients Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis
Authors: Mao Ziyang , Jia Xiaohui , Jiang Panpan , Wang Qinyang , Zhang Yajuan , Li Yanlin , Fu Xiaolan , Jiao Min , Jiang Lili , Liu Zhiyan , Guo Hui 
Published: May 2022

BackgroundDrug–drug interactions (DDIs) pose new challenges beyond traditional pharmacodynamics in the context of optimizing the treatment options with immune checkpoint inhibitors (ICIs). To alleviate cancer-related pain, analgesics are of absolute vital importance as chronic medications used by cancer patients. However, the possible outcome of ICI treatment concomitant with analgesics remains unclear.MethodsOriginal articles describing the possible influence of analgesics use on ICI treatment published before December 1, 2021 were retrieved from PubMed, Embase, and the Cochrane Library. Odds ratio (OR) with 95% confidence interval (CI) for objective response rate (ORR), hazard ratio (HR) with 95% CI for progression-free survival (PFS), and overall survival (OS) were calculated using the random-effects or fixed-effects model, and heterogeneity was assessed using the χ2-based Q-test. Publication bias was examined by funnel plot analysis.ResultsA total of 11 studies involving 4,404 patients were included. The pooled OR showed that opioid use decreased the response of opioid users to ICIs compared to non-opioid users (OR = 0.49, 95% CI = 0.37–0.65, p &lt; 0.001). Compared to patients who did not receive opioids, opioid users had an increased risk of progression and mortality (HR = 1.61, 95% CI = 1.37–1.89, p &lt; 0.001; HR = 1.67, 95% CI =1.30–2.14, p &lt; 0.001, respectively). Furthermore, the concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) was not significantly associated with differences in ORR, PFS, and OS in patients treated with ICIs (OR = 1.40, 95% CI = 0.84–2.32, p = 0.190; HR = 0.90, 95% CI = 0.77–1.06, p = 0.186; HR = 0.90, 95% CI = 0.71–1.14, p = 0.384, respectively).ConclusionThe concomitant use of opioids during ICI treatment has an adverse effect on patient prognosis, while the use of NSAIDs is not significantly associated with the prognosis in patients treated with ICIs.
Association of Inflammatory Cytokines With Non-Alcoholic Fatty Liver Disease
Authors: Duan Yamei , Pan Xiongfeng , Luo Jiayou , Xiao Xiang , Li Jingya , Bestman Prince L. , Luo Miyang 
Published: May 2022

BackgroundInflammatory cytokines have been considered to be significant factors contributing to the development and progression of non-alcoholic fatty liver disease (NAFLD). However, the role of inflammatory cytokines in NAFLD remains inconclusive.ObjectiveThis study aimed to evaluate the association between inflammatory cytokines and NAFLD.MethodsPubMed, Web of Science, the Cochrane Library, and EMBASE databases were searched until 31 December 2021 to identify eligible studies that reported the association of inflammatory cytokine with NAFLD and its subtypes. We pooled odds ratios (ORs) and hazard risk (HRs) with 95% confidence intervals (CIs) and conducted heterogeneity tests. Sensitivity analysis and analysis for publication bias were also carried out.ResultsThe search in the databases identified 51 relevant studies that investigated the association between 19 different inflammatory cytokines and NAFLD based on 36,074 patients and 47,052 controls. The results of the meta-analysis showed significant associations for C-reactive protein (CRP), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and intercellular adhesion molecule-1 (ICAM-1) with NAFLD (ORs of 1.41, 1.08, 1.50, 1.15 and 2.17, respectively). In contrast, we observed non-significant associations for interferon-γ (IFN-γ), insulin-like growth factor (IGF-II), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-7 (IL-7), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-12 (IL-12), monocyte chemoattractant protein-1(MCP-1), and transforming growth factor-β (TGF-β) with NAFLD. Our results also showed that CRP, IL-1β, and TNF-α were significantly associated with non-alcoholic steatohepatitis (NASH) and hepatic fibrosis.ConclusionsOur results indicated that increased CRP, IL‐1β, IL-6, TNF‐α, and ICAM-1 concentrations were significantly associated with increased risks of NAFLD. These inflammatory mediators may serve as biomarkers for NAFLD subjects and expect to provide new insights into the aetiology of NAFLD as well as early diagnosis and intervention.
Median Effective Analgesic Concentration of Ropivacaine in Ultrasound-Guided Interscalene Brachial Plexus Block as a Postoperative Analgesia for Proximal Humerus Fracture: A Prospective Double-Blind Up-Down Concentration-Finding Study
Authors: Liu Yang , Xu Cheng , Wang Chengyu , Gu Fei , Chen Rui , Lu Jie 
Published: May 2022

BackgroundThe innervation of the proximal humerus fracture is complicated and unclear. The use of interscalene nerve block has been effective as postoperative analgesia for patients, but the optimal concentration of usage is unknown.MethodThis study was conducted on 30 patients with ASA I or II, who were planning to undergo a proximal humerus fracture operation. A dosage of 10 ml Ropivacaine was administered for the interscalene brachial plexus block (ISBPB) as determined using the up-and-down sequential method. The initial concentration of Ropivacaine in the first patient to receive ISBPB was 0.3%. After a successful or unsuccessful postoperative analgesia, the concentration of local anesthetic was decreased or increased, respectively, by 0.05% in the next patient. We defined successful postoperative analgesia as a visual analog scale (VAS) score of &lt; 4 at rest, within the initial 8 h after ISBPB. The analytic techniques of linear, linear-logarithmic, exponential regressions, and centered isotonic regression were used to determine the EC50 of Ropivacaine, and the residual standard errors were calculated for the comparison of “goodness of fit.”ResultsThe concentration of Ropivacaine ranged from 0.1 to 0.35%. The EC50 (95% confidence interval) from 4 different statistical approaches (linear, linear-logarithmic, exponential regressions, and centered isotonic regression) were 0.222% (0.198%, 0.335%), 0.233% (0.215%, 0.453%), 0.223% (0.202%, 0.436%), and 0.232%, respectively. Among all the 4 models, the linear regression had the least residual standard error (0.1676).ConclusionThe EC50 from the four statistical models for 10 ml Ropivacaine in ultrasound-guided ISBPB for postoperative analgesia was distributed in a narrow range of 0.222–0.233%.Trial Registrationwww.chictr.org.cn/; registration number: ChiCTR2100047231.
Integrating Chronic Obstructive Pulmonary Disease Treatment With 8-Week Tai Chi Chuan Practice: An Exploration of Mind-Body Intervention and Neural Mechanism
Authors: Shen Haoran , Chen Li-Zhen , Hu Zhuoer , Yao Xiaoyan , Yang Tao , Zhang Lan , Tu Qiang , Li Guangxi , Wei Gao-Xia 
Published: May 2022

ObjectiveThis study aims to explore the effect of integrating routine treatment with Tai Chi Chuan (TCC) intervention on the clinical symptom of patients with Chronic Obstructive Pulmonary Disease (COPD) from clinical and neurological perspectives.MethodsTwenty patients with COPD were recruited for regular treatment combined with 8-week TCC rehabilitative practice. Clinical symptoms were evaluated by Chronic Obstructive Pulmonary Symptom Assessment Scale (CAT) and Modified Dyspnea Scale (mMRC) at baseline and after treatment. Resting-state MRI scan was also performed with multiline T2-weighted echo-planar imaging (EPI) to acquire their functional images before and after the treatment. TCC rehabilitation involved a total of 8 weeks of practice with 90 min per session, three times a week.ResultsAfter an 8-week integration routine treatment with TCC practice, the patient’s clinical symptoms improved significantly. Imaging analysis showed that COPD patients exhibited decreased Degree of Centrality (DC) in the right inferior frontal gyrus (IFG), right middle frontal gyrus, bilateral cingulate cortex, bilateral precuneus, and right precentral gyrus. Moreover, correlation analysis found that the decreased DC in the right IFG was positively correlated with the CAT improvements.ConclusionThe routine treatment involving TCC rehabilitation practice could improve the clinical symptoms of patients with COPD. The right IFG might be a key brain region to contribute to the neural mechanism underlying integrative intervention on the clinical symptoms in COPD. These findings provide neurological evidence for treating COPD rehabilitation practice with mind-body practice based on Chinese culture to some extent, which also advances the understanding of the efficacy of TCC as the adjuvant technology from a neuroscience perspective.Clinical Trial Registration:[http://www.chictr.org.cn/showproj.aspx?proj=45189], identifier [ChiCTR1900028335].
Neurophysiological Effects of the Anterior Cingulate Cortex on the Exacerbation of Crohn’s Disease: A Combined fMRI-MRS Study
Authors: Kong Ning , Gao Chen , Zhang Fan , Zhang Meng , Yue Juan , Lv Kun , Zhang Qi , Fan Yihong , Lv Bin , Zang Yufeng , Xu Maosheng 
Published: May 2022

BackgroundCrohn’s disease (CD) is characterized by repetitive phases of remission and exacerbation, the quality of life of patients with CD is strongly influenced by disease activity, as patients in the active phase experience significantly worse symptoms. To investigate the underlying mechanism of how the course of CD is exacerbated based on the bi-directionality of the brain-gut axis (BGA), we conducted a multi-modality neuroimaging study that combined resting-state functional magnetic resonance imaging (rs-fMRI) with proton magnetic resonance spectroscopy (MRS) to detect abnormalities in the anterior cingulate cortex (ACC).Materials and MethodsClinical scales including Visual Analog Scale (VAS) and Hospital Anxiety and Depression Scale (HADS) were used to evaluate the degree of abdominal pain and mood state of participants. We made a comparison between CD patients in the active phase, the remission phase and healthy controls (HCs), not only employed the innovative wavelet-transform to analyze the amplitude of low frequency fluctuation (ALFF) but also compared the sensitivity of wavelet-transform and the traditional fast Fourier transform (FFT). Brain metabolites such as glutamate (Glu), myo-inositol (mIns) and gamma-aminobutyric acid (GABA) were also detected. Then correlation analysis was made to see whether changes in the ACC correlated with CD’s clinical symptoms.ResultsCD patients in the active phase showed higher VAS scores (p = 0.025), the scores of anxiety and depression were also higher (all p &lt; 0.05). Wavelet-transform is slightly more sensitive in the current research. Patients in the active phase exhibited higher ALFF in the left ACC and the left superior frontal gyrus, medial (SFGmed). Patients in the active phase showed increased Glu levels in the ACC than patients in the remission phase or HCs (p = 0.039 and 0.034 respectively) and lower levels of mIns than HCs (p = 0.036). There was a positive correlation between mWavelet-ALFF values of the ACC and HADS-depression scores in CD patients (r = 0.462, p = 0.006). Besides, concentrations of Glu positively correlated with mWavelet-ALFF in the ACC in all participants (r = 0.367, p = 0.006).ConclusionAbnormal spontaneous activity and metabolic levels in the ACC were detected in CD patients in the active phase along with severer abdominal pain and worse mood state, these may contribute to the exacerbation of CD. Therefore, the ACC might be a potential neural alternative for managing the exacerbation of CD.
Leukocytes and Neutrophil–Lymphocyte Ratio as Indicators of Insulin Resistance in Overweight/Obese School-Children
Authors: Rodríguez-Rodríguez Elena , Salas-González M. Dolores , Ortega Rosa M. , López-Sobaler Ana M. 
Published: May 2022

Background and AimsInflammation in overweight/obesity may condition the development of insulin resistance (IR). New markers of inflammation and systemic inflammation, such as leukocyte and platelet counts, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), could be used as indicators of IR. The aim of the present study was to investigate the relationship between these markers and IR in overweight/obese children.Materials and MethodsA total of 1,035 schoolchildren were studied (398 overweight/obese). Anthropometric, hematological and biochemical measurements were collected. Inflammation was considered to be present when the values of leukocytes, platelets, NLR, PLR and MLR were ≥p75 for each sex. IR was defined as HOMA-IR &gt;3.16.ResultsIn overweight/obese schoolchildren, leukocytes were higher in both boys and girls, and platelets and NLR were higher in boys with IR than in boys with insulin sensitivity. An association between leucocytes and NLR values (≥p75) and IR was found in the entire population [2.911 (1.328–6.381); p = 0.008 and 2.660 (1.185–5.968); p = 0.018, respectively] and in boys [9.255 (1.896–45.168); p = 0.006 and 6.996 (1.377–35.544); p = 0.019, respectively].ConclusionElevated white blood cell values and elevated NLR in overweight/obese children, and particularly in boys, could be indicators of the presence of IR in these subjects and should be considered when predicting possible complications, such as type II diabetes mellitus.