bluuebunny/crossref_metadata_2025_split huggingface dataset:
New understanding of multidrug efflux and permeation in antibiotic resistance, persistence, and heteroresistance
Authors: Manrique Pedro D. , López Cesar A. , Gnanakaran S. , Rybenkov Valentin V. , Zgurskaya Helen I. 
Published: November 2022

AbstractAntibiotics effective against Gram‐negative ESKAPE pathogens are a critical area of unmet need. Infections caused by these pathogens are not only difficult to treat but finding new therapies to overcome Gram‐negative resistance is also a challenge. There are not enough antibiotics in development that target the most dangerous pathogens and there are not enough novel drugs in the pipeline. The major obstacle in the antibiotic discovery pipeline is the lack of understanding of how to breach antibiotic permeability barriers of Gram‐negative pathogens. These barriers are created by active efflux pumps acting across both the inner and the outer membranes. Overproduction of efflux pumps alone or together with either modification of the outer membrane or antibiotic‐inactivating enzymes and target mutations contribute to clinical levels of antibiotics resistance. Recent efforts have generated significant advances in the rationalization of compound efflux and permeation across the cell envelopes of Gram‐negative pathogens. Combined with earlier studies and novel mathematical models, these efforts have led to a multilevel understanding of how antibiotics permeate these barriers and how multidrug efflux and permeation contribute to the development of antibiotic resistance and heteroresistance. Here, we discuss the new developments in this area.
Asymmetry of Posterior Condyles in Resection Plane and Axial Curvature for Total Knee Arthroplasty
Authors: Li Changzhao , Chen Jiarong , Yang Yiming , jin Yan , Wang Cong , Tsai Tsung‐Yuan , Li Pingyue 
Published: November 2022

ObjectiveUnderstanding the morphology of the distal femur is essential for improving bone‐implant match in total knee arthroplasty (TKA) and understanding the mechanisms behind knee kinematics. However, little is known about the asymmetry of the posterior condyles. Thus, this study aimed to thoroughly investigate asymmetries in sizes and shapes between the medial and lateral posterior condyles before and after femoral resections during TKA in osteoarthritic (OA) knees.MethodsThree‐dimensional femoral models of 74 OA knees were constructed using computed tomography images. The morphologic measurements of the posterior condyle pre‐ and post‐simulated osteotomy for TKA included the radii of the posterior condyles fitted to a circle on the sagittal and axial planes of the femoral coordinate system, the inclination angle of the articular surface and resected surface, and the width and height of the resected surface. Differences in the data were assessed using Student's t‐test, and correlations were evaluated using the Pearson product–moment correlation.ResultsThe radii of the medial posterior condyles fitted to the circle were, on average, 6 mm larger than those of the lateral condyles on the axial plane (p < 0.001) and 0.7 mm smaller than those of the lateral condyles on the sagittal plane (p = 0.046). The inclination angles of the medial and lateral posterior condyles on the axial plane were significantly different with both pre‐simulated and post‐simulated osteotomy, respectively (both p < 0.001). The resected plane of the lateral posterior condyles displaced opposite inclination directions between the distal and proximal portions. Neither heights or widths of the medial posterior condyles were significantly different from those of their lateral counterparts (both p > 0.107).ConclusionsThis study found asymmetrical inclination of the resected surface and coronal radii between the medial and lateral posterior condyles, which may relate to the posterolateral overhang of the lateral condyle after TKA and the progression of the knee OA. These findings provides valuable morphological information and may help improve the implant designs for TKA.
The Effect of Arthroscopic Extra‐Articular Entire Coracohumeral Ligament Release for Patients with Recalcitrant Frozen Shoulder
Authors: Li Dan‐mei , Zhang Chuan , Xiang Xian‐Xiang , Cheng Yong‐Feng , Zhang Lai‐Fu , Ma Kun 
Published: November 2022

ObjectiveThe thickened coracohumeral ligament (CHL) is an important part of the typical manifestations and magnetic resonance imaging of frozen shoulder. However, only a few clinical studies with limited cases on arthroscopic extra‐articular entire CHL release exist in the literature. This study was to evaluate the effect of arthroscopic extra‐articular entire CHL release for patients with recalcitrant frozen shoulder.MethodsFrom February 2014 to February 2020, 81 cases of recalcitrant frozen shoulder patients treated with surgery in a single‐center shoulder department and followed for more than 2 years were analyzed. Arthroscopic 360° capsular release was performed with intra‐articular partial release (IPR group) or additional extra‐articular entire release (IPR + EER group) of CHL. The same rehabilitation program was performed after surgery in both groups. Visual analogue scale (VAS) for pain, range of motion (ROM), and the Constant–Murley scoring system was evaluated before operation, at 3 months after operation, 6 months after operation, and the final follow‐up. T‐test, Mann–Whitney U‐test and chi‐squared test were used to compared data.ResultsThere were 39 patients in the IPR group, with an average follow‐up of 29.2 months. A total of Forty‐two patients in the IPR + EER group completed a mean follow‐up of 25.7 months. All incisions healed in stages. There were significant differences in Constant–Murley shoulder score, VAS score, and ROM before operation and at the final follow‐up in both groups (both P < 0.001). The VAS score of the IPR + EER group was lower than that of the IPR group at 3 months after surgery (P < 0.05), and 6 months after operation (P < 0.05). External rotation, internal rotation, and abduction of ROMs and Constant–Murley shoulder score were significantly greater in the IPR + EER group at 3 months (P < 0.001, P < 0.05, P < 0.001, P < 0.05, respectively) and 6 months after operation (P < 0.001, P < 0.05, P < 0.001, P < 0.05, respectively). At the last follow‐up, there was no significant difference in forward flexion, internal rotation, and abduction of ROMs, VAS, and the Constant–Murley shoulder score between the IPR and IPR + EER groups. The external rotation of the IPR + EER group was still greater than that of the IPR group at the last follow‐up (P < 0.001).ConclusionArthroscopic extra‐articular entire coracohumeral ligament release could solve early pain of shoulder joint, recover shoulder joint functions effectively, and achieve a satisfactory efficacy in the treatment of recalcitrant frozen shoulder.
Mental health mobile application self‐help for adolescents exhibiting psychological distress: A single case experimental design
Authors: Badesha Kiran , Wilde Sarah , Dawson David L. 
Published: November 2022

AbstractObjectivesThe present demand for child and adolescent mental health services exceeds the capacity for service provision. Greater research is required to understand the utility of accessible self‐help interventions, such as mobile apps. This study sought to investigate whether use of a mental health app, underpinned by CBT, led to changes in psychological distress amongst adolescents. Mechanisms of change were examined, specifically whether changes are attributable to cognitive strategies.DesignThis study utilised a multiple‐baseline single‐case experimental design, tracking variables across baseline and intervention phases. Surveys assessing participant experience were also administered.MethodsFive participants with moderate‐to‐severe levels of psychological distress engaged with a CBT‐based app over five weeks. Participants were recruited from both a well‐being service and the general population. Supplementary weekly calls to participants offered clarification of app content.ResultsA small overall effect of the intervention of psychological distress was evident; however, outcomes were dependent on the analysis conducted. The intervention appeared to promote an increase in use of adaptive cognitive strategies but not negative thinking styles. The CBT app did not promote changes in participant well‐being. Participant feedback highlighted practical challenges of utilising the app.ConclusionsThe clinical benefits of app‐based CBT were small, and a range of barriers to engagement were recognised. While further research is required, caution should be exercised in the interpretation of studies reporting on app effectiveness.
Neo‐Humean rationality and two types of principles
Authors: Strandberg Caj 
Published: November 2022

AbstractAccording to the received view in metaethics, a Neo‐Humean theory of rationality entails that there cannot be any objective moral reasons, i.e. moral reasons that are independent of actual desires. In this paper, I argue that there is a version of this theory that is compatible with the existence of objective moral reasons. The key is to distinguish between (i) the process of rational deliberation that starts off in an agent's actual desires, and (ii) the rational principle that an agent employs in such a process. I maintain that it is the latter which explains why it is rational for an agent to have a certain desire, not the former. As a result, there might be two types of principles. The second type of principle leaves room for objective moral reasons.
Migrationsland DDR? Recuperating the Histories of Non‐European Vertragsarbeiter*innen in the GDR and Beyond
Authors: Nenno Nancy P. 
Published: November 2022

AbstractThe current focus on diversity and inclusion amid calls to decolonize the German curriculum prompts us once again to examine what we understand to be “German” about German Studies. This article pursues this agenda by addressing a lacuna in our understanding and representation of migrants to Germany, specifically the presence, history, and legacies of labor migrants to East Germany. The first half of this article contextualizes the German Democratic Republic's (GDR) recruitment of foreign workers and examines key similarities and differences between the East and West German guest worker program models. This section focuses particularly on the labor migrants recruited from the Socialist Republic of Vietnam and the People's Republic of Mozambique – the largest cohorts of non‐European workers recruited by the GDR – and concludes with a brief overview of the long afterlife of the Vertragsarbeiter*innen through the Wende, reunification, and beyond. The second section offers a range of texts and assignments keyed to the Common European Framework of Reference for Languages (CEFR) guidelines for integrating the narratives of Vertragsarbeiter*innen into German language and Studies curricula. Recuperating the history of non‐European contract workers in East Germany serves to expand our conception of German Studies and to dismantle artificially exclusive boundaries, thereby working toward the deterritorialization of the discipline.
Heat Transfer and Friction in a Rectangular Channel With Varying Numbers of Walls Roughened With 90-Deg Transverse or 45-Deg V-Shaped Ribs
Authors: Alsaleem Sulaiman M. , Wright Lesley M. , Han Je-Chin 
Published: November 2022

Abstract
An experimental investigation was performed to measure the regionally averaged heat transfer distributions and friction factors for fully developed turbulent flow in a rectangular channel with a width-to-height aspect ratio (AR = 3). Data for transverse 90-deg and 45-deg V-shaped, carbon steel ribs placed on one, two, or four sides of the channel were reported for a Reynolds number range (Re = 5,000–60,000). The pitch-to-rib height ratio (P/e) was set at 10 while the rib height-to-channel hydraulic diameter (e/Dh) is 0.041. This corresponds to a roughness Reynolds number range (e+=25−500). For both rib configurations, results show the highest thermal performance was achieved in the channels with four-ribbed wall followed by the two and one-ribbed wall channels, respectively. Using the law of the wall similarity, friction roughness functions (R) and heat transfer roughness functions (G) were developed based on four-sided friction and heat transfer data. Moreover, friction and heat transfer data of similar rib designs were obtained from literature and correlated to the corresponding friction and heat transfer roughness functions. Covering a wide range of roughness Reynolds numbers, more robust heat transfer and friction correlations were developed which can be used by designers to accurately predict both heat transfer and friction in ribbed channels with different numbers of ribbed walls. Using these correlations, one can predict the measured friction and heat transfer data of this study with maximum errors of 9% and 7%, respectively.
Optimal Design of a Kinematically Redundant Planar Parallel Mechanism Based on Error Sensitivity and Workspace
Authors: Li Xiao , Qu Haibo , Li Guanming , Guo Sheng , Dong Guoqiang 
Published: November 2022

Abstract
In this paper, the dimensional optimization of a (2PRR)-R + 2RRR (P and R represent the prismatic and revolute joint, respectively, and the underline indicates that the joint is the actuator) kinematically redundant parallel mechanism is performed by taking the integrated error sensitivity index and workspace as the objectives. Based on the matrix method, a generalized method for error modeling of the planar three-degree-of-freedom (3-DOF) parallel mechanism is proposed. The process of the generalized error modeling method is explained, and the error model of the planar (2PRR)-R + 2RRR kinematically redundant parallel mechanism is established. Based on the proposed error model, the error sensitivity indices of different dimension types are calculated. In order to reduce the error sensitivity and expand the workspace, the elitist non-dominated sorting genetic algorithm (NSGA-II) is used for multi-objective optimization of the mechanism. The comparative analysis between the optimized and the non-optimized mechanism is carried out from three aspects: error sensitivity, distribution of low-error sensitivity area, and area of the workspace. The results show that the optimization algorithm not only expands the workspace of the mechanism but also effectively reduces the error sensitivity in the workspace.
Experimental Subsonic Flutter of a Linear Turbine Blade Cascade With Various Mode Shapes and Chordwise Torsion Axis Locations
Authors: Eret Petr , Tsymbalyuk Volodymyr 
Published: November 2022

Abstract
Axial flow turbomachinery is susceptible to self-excited vibrations known as flutter, primarily affecting high-aspect ratio rotor blades. Experimental studies of blade flutter are essential to understanding the phenomenon. The existing research has shown that the most critical factor in determining the aerodynamic stability of the blade is the mode shape. In this work, measurements of subsonic flutter of a linear turbine blade cascade with various mode shapes and torsion axis locations in a chordwise direction are carried out. The cascade consists of eight blades representing the reduced tip sections of the last stage blade of the steam turbine rotor, and central four flexibly mounted blades are forced to vibrate in pure bending and pure torsion modes and a combined motion. Both the traveling wave mode approach and the influence coefficient method are tested. The results show that the pure torsion mode is insensitive to increasing reduced frequency and is aerodynamically unstable for each positive angle of incidence tested, while pure bending and combined modes become less stable with the increased angle of incidence. In addition, high sensitivity of blade behavior to changes in torsion axis position and phase shift between bending and torsion motions is demonstrated.
Supplemental Material: Europium anomalies in detrital zircons record major transitions in Earth geodynamics at 2.5 Ga and 0.9 Ga
Authors: Triantafyllou Antoine , al. et 
Published: November 2022

<p>Additional figures, datasets with a compilation of detrital zircon data (U-Pb and trace element) and references; the detailed statistical treatment for zircon U-Pb and trace composition as well as the parameters and solid solution models used for thermodynamic modelling; and links to a GitHub repository that contains two Python codes built to perform bootstrap analysis and timeseries plotting on the zircon U-Pb and trace elements dataset. </p>
Prognostic factors for pleomorphic dermal sarcoma: analysis of 1911 cases from the SEER database
Authors: Perez Alexander N , Dashti Nooshin K , Cates Justin M M 
Published: November 2022

Prognostic factors for pleomorphic dermal sarcoma, a rare undifferentiated neoplasm of the skin, are poorly defined, and typical staging systems do not appear to be appropriate for these neoplasms. We; therefore, sought to identify prognostic factors for disease-specific survival and predictors of metastasis.Pleomorphic dermal sarcomas were identified in the Surveillance, Epidemiology and End Results database (N=1911). Multiple imputation was used to overcome inherent limitations in this dataset to assess prognostic factors using multivariable Cox proportional hazard stratified by (neo)adjuvant radiotherapy and logistic regression for presentation with metastasis.Age, tumour size and metastasis were independent prognostic factors for cutaneous sarcoma-specific survival. Only tumour size was associated with increased odds of presentation with metastasis, with tumours >4 cm at highest risk. Metastasis is the most important factor in determining outcomes, with age and size as lesser factors. Only tumour size is predictive of metastasis, with larger tumours at highest risk.
Comparative analyses of tumour immune microenvironment between collecting duct carcinoma and fumarate hydratase-deficient renal cell carcinoma
Authors: Kiyozawa Daisuke , Kohashi Kenichi , Takamatsu Dai , Umekita Shinya , Eto Masatoshi , Kinjo Mitsuru , Nishiyama Kenichi , Taguchi Kenichi , Oshiro Yumi , Kuboyama Yusuke , Oda Yoshinao 
Published: November 2022

AimsCollecting duct carcinoma (CDC) and fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) have similar histological morphologies and both show a poor prognosis. Programmed death ligand 1 (PD-L1) inhibitor has been approved for the treatment of RCC. However, tumour-infiltrating neutrophils stimulated by interleukin-8 (IL-8) interfere with PD-L1 inhibitors. Here, we retrospectively analysed PD-L1 and IL-8 expression, and examined its relationship with infiltrating immune cells.MethodsNine cases of CDC and seven cases of FH-deficient RCC were selected. We defined PD-L1 and IL-8 expression by the Tumour Proportion Score and Combined Positive Score (CPS). We counted the numbers of CD8+, CXCR2+, CD11b+, CD66b+and CD33+immune cells located in the tumour components.ResultsA number of CXCR2+(p=0.0058), CD11b+(p=0.0070) and CD66b+(p=0.0067) immune cells infiltrating into CDC were significantly higher than those infiltrating into FH-deficient RCC. In CDC, PD-L1 expression was correlated with a high density of CD8+lymphocytes (p=0.0389), but was not in FH-deficient RCC (p=0.6985). IL-8 CPS was significantly higher in CDC than in FH-deficient RCC (p=0.0069). In addition, among the CDC cases, IL-8 CPS showed significant positive correlations with CXCR2+, CD11b+and CD66b+immune cell densities (p=0.0250, p=0.0104 and p=0.0374, respectively), whereas FH-deficient RCC showed no significant correlations between IL-8 CPS and immune cell densities.ConclusionsOur results suggest the difference of each tumour microenvironment between CDC and FH-deficient RCC, and IL-8 is a potential therapeutic target for treating CDC, but not FH-deficient RCC.
New species and new distributional records of the hygropetric water scavenger beetle genus Ephydrolithus Girón & Short (Coleoptera: Hydrophilidae) from the Brazilian Shield
Authors: Alencar Janderson Batista R. , Serra Myllena Bastos , Short Andrew Edward Z. , Hamada Neusa 
Published: November 2022

The water scavenger beetle Ephydrolithus Girón and Short, 2019 contains five species, all occurring in the southeastern region of Brazil. In this paper, 5 new species are described from the Brazilian Shield, bringing the number of species in the genus to 10: Ephydrolithus bentoi sp. nov., Ephydrolithus cipo sp. nov., Ephydrolithus mucugensis sp. nov., Ephydrolithus serro sp. nov., and Ephydrolithus vivas sp. nov. New geographical records in the Brazilian Shield are provided for Ephydrolithus hamadae Girón and Short, 2019, Ephydrolithus spiculatus Girón and Short, 2019, and Ephydrolithus teli Girón and Short, 2019. Corroborating the previously described habitat for the genus, all new species are associated with hygropetric zones such as wet rocks, waterfalls, and seepages. An updated key to identify adults of Ephydrolithus is provided.
Stellar neutron capture reactions at low and high temperature
Authors: Rauscher Thomas 
Published: November 2022

AbstractThe determination of astrophysical reaction rates requires different approaches depending on the conditions in hydrostatic and explosive burning. The focus here is on astrophysical reaction rates for radiative neutron capture reactions. Relevant nucleosynthesis processes not only involve the s-process but also the i-, r- and $$\gamma $$
γ
-processes, which from the nuclear perspective mainly differ in the relative interaction energies of neutrons and nuclei, and in the nuclear level densities of the involved nuclei. Emphasis is put on the difference between reactions at low and high temperature. Possible complications in the prediction and measurement of these reaction rates are illustrated and the connection between theory and experiment is addressed.
Multiparticle production in proton–nucleus collisions beyond eikonal accuracy
Authors: Agostini Pedro , Altinoluk Tolga , Armesto Néstor , Dominguez Fabio , Milhano José Guilherme 
Published: November 2022

AbstractWe study the effects on multigluon production at mid-rapidity in the Color Glass Condensate of the non-eikonal corrections that stem from relaxing the shockwave approximation and giving the target a finite size. We extend previous works performed in the dilute-dilute approximation suitable for proton–proton collisions, to the dilute-dense one applicable to proton–nucleus. We employ the McLerran–Venugopalan model for the projectile averages. For the target averages, we use the Golec-Biernat–Wüsthoff model and restrict to the leading contributions in overlap area that allow a factorization of ensembles of Wilson lines into products of dipoles. We make the connection with the jet quenching formalism and compare with previous results in the literature, providing a parametrization of the so-called decorated dipoles. We show that the non-eikonal effects on single inclusive particle production, contrary to what happens in jet quenching, are only sizable, of a few percent, for modest energies $$\sqrt{s_{NN}}\le 100$$

s

NN

≤
100

GeV and central rapidities. On the other hand, we find that the effects on double inclusive gluon production are larger for the same kinematics. We show that, as found previously in the dilute-dilute situation, non-eikonal corrections break the accidental symmetry in the CGC, allowing for the existence of non-vanishing odd azimuthal harmonics.