bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: A prediction model for a concentrating solar thermoelectric generator using artificial neural networks and extreme learning machines
Authors: Maduabuchi Chika , Al-Dahidi Sameer , Alnami Hashim , Alsuwian Turki 
Published: August 2022

Abstract
The current numerical simulation tools used to optimize the performance of concentrating solar thermoelectric generators are extremely time consuming, and consequently require expensive computational energies. Furthermore, they are incapable of considering the effects of diverse real-life operating conditions on the performance of the system. Additionally, they sometimes neglect temperature dependency in the thermoelectric semiconductors and base their studies on just unicouple thermoelectric cells to avoid the further complexity of the numerical computation. These factors limit the flexibility of optimization studies that can be conducted on solar thermoelectrics; hence, limiting the insights that can be drawn to design high performing solar thermoelectric generators. This work is the first of its kind to introduce artificial neural networks and extreme learning machines as a substitute to these numerical methods to accelerate and ease the design process of solar thermoelectric generators. The data generation process is conducted using a 3-dimensional numerical model developed in ANSYS numerical solver and the optimized parameters include the high-temperature material content, semiconductor height and area, concentrated solar irradiance, cooling film coefficient, wind speed, and ambient temperature – on the system performance. A full-scale customized thermoelectric module comprising 127 thermocouples is designed and integrated in an optical concentrator for solar power generation while considering temperature dependency in all thermoelectric materials. Results depict that the geometry and operating condition optimization improved the system power and efficiency by 42.02% and 82.23%, respectively. Furthermore, the artificial neural network had the highest regression of 95.82% with the least mean squared error of 2.71 \(\times\) 10− 5 in learning the numerical-generated data set while performing 389 and 203 times faster than the numerical method in forecasting the system power and efficiency, respectively. Finally, methods of manufacturing the optimized thermoelectric module using 3-dimensional printing are discussed.
Efficient purification and characterization of high-purity phycoerythrin 545 from Rhodomonas sp.
Authors: Pu Yang , Dong Shuo , Li Min , Dong Kai , Zhao Huawei , Tang Zhihong , Li Wenjun 
Published: August 2022

Abstract
Cryptomonad phycoerythrin 545 is an important type of phycobiliprotein in basic research and technological innovations. Herein, we report a minimalistic hydrophobic chromatography method for its purification. High purity was achieved, with a purity ratio (A545/A280) of 13.66 and a recovery ratio of 78.63%. Following SDS-PAGE, Coomassie Brilliant Blue staining and Zn2+-enhanced UV fluorescence autoradiography revealed three bands at 9 kDa, 10 kDa, and 20 kDa, corresponding to α1, α2 and β subunits. Multiple spectral characteristics were analysed to ensure that optical activity was consistent with that of the natural protein. Absorption and fluorescence spectroscopies of purified phycoerythrin 545 displayed a strong absorption peak at 545 nm and a shoulder peak at 564 nm, and a fluorescence emission peak of at 587 nm, which confirmed unchanged energy transfer properties, and structural and functional integrity was verified by circular dichroism spectroscopy. Compared with published purification methods, this new purification protocol replaces two-step ammonium sulphate fractionation, dialysis, and size exclusion chromatography with a single chromatography step, thereby reducing the cost of large-scale kilogram-level commercial production.
Impairment of electron transport chain and induction of apoptosis by chrysin nanoparticles targeting succinate-ubiquinone oxidoreductase in pancreatic and lung cancer cells
Authors: Ragab Eman M. , Gamal Doaa M El , Mohamed Tarek M. , Khamis Abeer A. 
Published: August 2022

Abstract
Background: Flavonoids may help ameliorate the incidence of the major causes of tumor-related mortality, such as pancreatic ductal adenocarcinoma (PDAC) and lung cancer, that are predicted to steadily increase between 2020 to 2030. Here we compared the effect of chrysin and chrysin nanoparticles (CCNPs) with 5-fluorouracil (5-FLU) on the activity and expression of mitochondrial complex II (CII) to induce apoptosis in pancreatic (PANC-1) and lung (A549) cancer cells.Methods: The binding affinity of chrysin to succinate dehydrogenase (SDH) was studied using molecular docking. CCNPs were synthesized and characterized, and the IC50 was evaluated in normal, PANC-1, and A549 cell lines using the MTT assay. The effect of chrysin and CCNPs on CΙΙ activity, superoxide dismutase activity, and mitochondria swelling were evaluated. Apoptosis was assessed using flow cytometry, and expression of the C and D subunits of SDH, sirtuin-3 (SIRT-3), and hypoxia-inducible factor (HIF-1α) was evaluated using RT-qPCR.Results: The IC50 of CII subunit C and D binding to chrysin was determined and used to evaluate the effectiveness of treatment on the activity of SDH with ubiquinone oxidoreductase. Enzyme activity was significantly decreased (chrysin < CCNPs < 5-FLU and CCNPs < chrysin < 5-FLU, respectively), which was confirmed by the significant decrease of expression of SDH C and D, SIRT-3, and HIF-1α mRNA (CCNPs < chrysin < 5-FLU). There was also a significant increase in the apoptotic effects (CCNPs > chrysin > 5-FLU) in both PANC-1 and A549 cells and a significant increase in mitochondria swelling (CCNPs < chrysin < 5-FLU and CCNPs > chrysin > 5-FLU, respectively) than that in non-cancerous cells.Conclusion: Treatment with CCNPs improved the effect of chrysin on succinate-ubiquinone oxidoreductase activity and expression and therefore has potential as a more efficient formulation than chemotherapy to prevent metastasis and angiogenesis by targeting HIF-1α in PDAC and lung cancer.
Comprehensive Analysis of Prognosis and Immune Function of CD70-CD27 Signaling Axis in Pan-Cancer
Authors: Kong Fanhua , Xiong Yan , Ye Qifa 
Published: August 2022

Abstract
The immune checkpoint molecule CD70 and its receptor CD27 constitute the signal transduction axis, which is abnormally expressed in many solid tumors and is crucial for T cell co-stimulation and immune escape. Tumor cells regulate the expression of CD27 by expressing CD70 in tumor microenvironment and promote immune escape.The discovery of the immunosuppressive effect of the CD70-CD27 signaling axis on tumor cells introduces a new anti-tumor immunotherapy - CD70. Although current research evidence suggests a link between CD70 and tumors, no pan-cancer analysis is available. Using the Cancer Genome Atlas and Gene Expression Omnibus datasets, we first explored the potential carcinogenic role of the CD70-CD27 signaling axis in human malignancies. CD70 expression is up-regulated in most cancers and has an obvious correlation with the prognosis of tumor patients. The expression of CD70 and CD27 is associated with the level of regulatory T cells (Tregs) infiltration. In addition, T cell receptor signaling pathways, PI3K-Akt, NF-κB, and TNF signaling pathways are also involved in CD70-mediated immune escape. CD70 mainly regulates tumor immune escape by regulating T cell-mediated tumor killing, while Tregs may be its main T cell subset. Our first pan-cancer study provides a relatively comprehensive understanding of the carcinogenic role of the CD70-CD27 signaling axis in different tumors.
Convolutional neural network quantification of Gleason pattern 4 and association with biochemical recurrence in intermediate grade prostate tumors
Authors: Chen Yalei , Loveless Ian , Nakai Tiffany , Newaz Rehnuma , Abdollah Firas , Rogers Craig , Hassan Oudai , Chitale Dhananjay , Arora Kanika , Williamson Sean , Gupta Nilesh , Rybicki Benjamin , Sadasivan Sudha , Levin Albert 
Published: August 2022

Abstract

Differential classification of prostate cancer (CaP) grade group (GG) 2 and 3 tumors remains challenging, likely due to the subjective quantification of percentage of Gleason pattern 4 (%GP4). Artificial intelligence assessment of %GP4 may improve its accuracy and reproducibility and provide information for prognosis prediction. To investigate this potential, a convolutional neural network (CNN) model was trained to objectively identify and quantify Gleason pattern (GP) 3 and 4 areas, estimate %GP4, and assess whether CNN-assessed %GP4 is associated with biochemical recurrence (BCR) risk in intermediate risk GG 2 and 3 tumors. The study was conducted in a radical prostatectomy cohort (1999–2012) of African American men from the Henry Ford Health System (Detroit, Michigan). A CNN model that could discriminate four tissue types (stroma, benign glands, GP3 glands, and GP4 glands) was developed using histopathologic images containing GG 1 (n = 45) and 4 (n = 20) tumor foci. The CNN model was applied to GG 2 (n = 153) and 3 (n = 62) for %GP4 estimation, and Cox proportional hazard modeling was used to assess the association of %GP4 and BCR, accounting for other clinicopathologic features including GG. The CNN model achieved an overall accuracy of 86% in distinguishing the four tissue types. Further, CNN-assessed %GP4 was significantly higher in GG 3 compared with GG 2 tumors (p = 7.2*10− 11). %GP4 was associated with an increased risk of BCR (adjusted HR = 1.09 per 10% increase in %GP4, p = 0.010) in GG 2 and 3 tumors. Within GG 2 tumors specifically, %GP4 was more strongly associated with BCR (adjusted HR = 1.12, p = 0.006). Our findings demonstrate the feasibility of CNN-assessed %GP4 estimation, which is associated with BCR risk. This objective approach could be added to the standard pathological assessment for patients with GG 2 and 3 tumors and act as a surrogate for specialist genitourinary pathologist evaluation when such consultation is not available.
On real center singularities of complex vector fields on surfaces
Authors: SCARDUA BRUNO , Leon Victor 
Published: August 2022

Abstract
One of the various versions of the classical Lyapunov-Poincaré center theorem states that a nondegenerate real analytic center type planar vector field singularity admits an analytic first integral. In a more proof of this result, R. Moussu establishes important connection between this result and the theory of singularities of holomorphic foliations (\cite{moussu}). In this paper we consider generalizations for two main frameworks: (i) planar real analytic vector fields with ``many'' periodic orbits near the singularity and (ii) germs of holomorphic foliations having a suitable singularity in dimension two.
In this paper we prove versions of Poincar\'e-Lyapunov center theorem, including for the case of holomorphic vector fields. We also give some applications, hinting that there is much more to be explored in this framework.
Re-thinking on land degradation and its impacts on livelihoods of the farmers in Kanungu District, Uganda
Authors: Turyasingura Benson , Ayiga Natal , Benzougagh Brahim 
Published: August 2022

Abstract
Land degradation has made it difficult for people to make a living in Uganda, one of the world's poorest nations. Land degradation in Uganda poses a severe danger to rural populations' ability to support themselves. The primary natural resource used by humans for economic, social, infrastructure, and other human endeavors is land. Land resources are so crucial in determining rural livelihoods, and the absence of sustainable land management techniques results in land degradation. This study looked at the Kanungu district in southwestern Uganda in order to examine the relationship between land degradation and rural populations' ability to support themselves. Additionally, the factors that affect households in the study area's ability to diversify their sources of income are covered. The objective of this paper is to provide an in-depth understanding of the causes of land degradation and its impacts on livelihoods, as well as possible solutions to the impacts of land degradation in Kanungu district. To achieve these objectives, the study used a cross-sectional research approach, where the information gathered reflects the state of affairs at a specific time, making it possible to gather insightful information quickly. Since a cross-sectional survey allows for the gathering of data using a range of techniques, a mixed method was used in this study, combining quantitative and qualitative techniques. As a result, the study findings proved that there was a significant positive relationship between the effects of land degradation and the livelihoods of farmers (p 0.01, r =.530**) in Kanungu District, which suggests that adoption of new seed varieties which can withstand harsh climatic conditions, strengthening agricultural reforms, and agroforestry would improve the livelihoods of local farmers to improve their savings and production of quality crop products. Therefore, the alternative hypothesis was therefore accepted and it was concluded that "There is a significant relationship between land degradation and the livelihoods of farmers in Kanungu District." Hence, it can be concluded that land degradation significantly affects the livelihoods of farmers. It is also concluded that a majority of the participants agree that deforestation causes land degradation.
COVİD-19 PANDEMİ SÜRECİNDE ENGELLİ ÇOCUKLARIN FONKSİYONELLİĞİ İLE EBEVEYNLERİN ETKİLENİMLERİ ARASINDAKİ İLİŞKİ
Authors: ŞEN Güliz , AYTAR Aydan 
Published: August 2022

Amaç: Bu çalışmanın amacı Covid-19 pandemi sürecinde engelli çocukların fonksiyonelliği ile ebeveynlerin etkilenimleri arasındaki ilişkiyi araştırmaktı.
Yöntem: Çalışmaya 4-12 yaş arasında 84 engelli çocuk ve 84 anne olmak üzere toplam 168 kişi dahil edildi. Engelli çocuklar için Pediatrik Özürlülük Değerlendirmesi Envanteri (PÖDE) ve Kaba Motor Fonksiyon Sınıflandırma Sistemi (KMFSS) kullanıldı. Annelere Zarit Bakım Verme Yükü Ölçeği (ZBVYÖ), Yorgunluk Şiddet Ölçeği (YŞÖ) ve kas-iskelet sistemi rahatsızlıklarını sorgulamak için İskandinav Kas İskelet Sistemi Sorgusu (İKİSS) uygulandı.
Sonuçlar: Bakım yükü puanı ile PÖDE toplam puanı, kendine bakım ve mobilite puanları arasında herhangi bir ilişki görülmedi (p>0,05). Bakım yükü puanı ile sosyal fonksiyon puanı arasında ise orta düzeyde negatif yönde (r=-0,306; p0,05). Bakım yükü puanı ile yorgunluk şiddet puanı arasında ilişki tespit edilmedi (p>0,05). Ebeveynlerin son 12 ay süresince sadece bel bölgesindeki ağrı olağan işlerini yapmayı engelledi. Son 12 ay süresince kas iskelet sistemi ağrısından yakınan ebeveynlerde en çok ağrıyan vücut bölümleri bel, boyun, omuz, sırt, diz bölgesinde olduğu tespit edildi.
Tartışma: Covid-19 pandemi sürecinde engelli çocukların fonksiyonelliği ile ebeveynlerinin etkilenimleri arasında bir ilişki olmadığı bulundu.
PENGEMBANGAN SISTEM KOMUNIKASI AUGMENTATIF DAN ALTERNATIF PADA NOTASI DALAM PEMBELAJARAN MUSIK ANAK AUTIS
Authors: Erlani Lalan , Bachtiar Ishak Gerard , Taboer Arif 
Published: August 2022

Program layanan pembelajaran musik bagi anak autis dalam implementasinya masih banyak kendala dalam komunikasi antara guru dan siswa. Penelitian menunjukkan sebesar 50% anak dengan spektrum autistik tidak akan mengembangkan kemampuan bicara yang memadai untuk memenuhi kebutuhan komunikasinya. Sehingga alat komunikasi seperti Augmentative and Alternative Communication (AAC) menjadi diperlukan. Penelitian ini bertujuan menemukan penggunaan yang tepat Augmentative and Alternative Communication (AAC) pada notasi yang tepat dalam pembelajaran musik bagi anak autis yaitu bagaimana pengembangan sistem AAC dalam pembelajaran musik serta dampaknya pada kemampuan musik bagi anak autis. Mixed Method Research sebagai pendekatan dengan kualitatif deskriptif untuk mengeksplore data dalam menemukan ketepatan sistem AAC dan Single Subject Research untuk menganalisis perubahan kemampuan subjek. Tejuannya (1) Penggunaan AAC untuk pengembangan pada notasi musik anak autis adalah pengembangan kartu AAC berbasis asesmen yang dikelompokan berdasarkan materi, (2) Analisis dampak pengembangan yang berdampak signifikan terhadap penggunaan AAC pada notasi pembelajaran musik bagi anak autis yang ditunjukan pada perubahan kemampuan musik materi notasi, dinamika dan tempo dengan mendukung fungsi komunikasi pada pembelajaran. Penelitian ini dapat menjadi pertimbangan mendasar dalam pengembangan sistem AAC selanjutnya
KEBIASAAN MAKAN PAGI PADA ANAK USIA SD DAN HUBUNGANNYA DENGAN TINGKAT KESEHATAN DAN PRESTASI BELAJAR
Authors: Sukiniarti Sukiniarti 
Published: August 2022

Makanan sehari-hari yang dipilih dengan baik akan memberikan semua zat yang diperlukan oleh tubuh untuk hidup sehat. Khususnya untuk anak usia sekolah dasar yang dikategorikan masih dalam taraf perkembangan dan pertumbuhan, maka makan pagi sangat diperlukan untuk menunjang aktivitasnya. R.E.Kleinman (2013), mengatakan bahwa anak yang tidak sarapan pagi cenderung tidak konsentrasi dalam belajar. Tujuan penelitian ini untuk mengidentifikasi: (1) seberapa banyak anak usia SD membiasakan makan pagi sebelum berangkat sekolah. (2) penyebab anak usia SD tidak makan pagi sebelum berangkat sekolah. (3) hubungan makan pagi dengan tingkat kesehatan dan prestasi belajar anak usia SD. Metode yang digunakan metode kuantitatif. Informasi pengambilan data digali melalui survai, dokumentasi dan wawancara. Hasil penelitian menunjukkan:(1) 89,66% anak setiap pagi selalu makan pagi sebelum berangkat sekolah. (2) 43,11% anak usia SD kelas 2 tidak makan pagi sebelum berangkat sekolah dikarenakan bangun kesiangan. (3) Hubungan antara makan pagi dengan tingkat kesehatan dan prestasi belajar anak SD kelas 2 di wilayah Kelurahan Pondok Benda tidak begitu erat, dikarenakan adanya faktor genetik.
HUBUNGAN ANTARA ASPEK DALAM MOTIVASI BELAJAR DENGAN HASIL BELAJAR KOGNITIF BIOLOGI SISWA KELAS XI SMA NEGERI 8 BATAM
Authors: Nurhaty Destaria Sudirman , Sari Purnama , Notowinarto Notowinarto 
Published: August 2022

Penelitian ini menggunakan pendekatan korelasial antar subjek dengan menggunakan teknik purposive sampling yaitu 109 siswa kelas XI sebagai responden. Hasil penelitian menunjukkan, bahwa: (1) tidak ada hubungan antara motivasi belajar intrinstik dengan hasil belajar kognitif biologi; hubungan tidak normal (nilai Lhitung 0.0358 < Ltabel 0.0850); hubungan tidak signifikan (Fhitung 0.755 < Ftabel 1.5); nilai persamaan Y= 79.60 + 0.035 X1; nilai koefisien korelasi (r1y) = 0,076 (7,6%); nilai koefisien determinasi (KD/R12y) = 0,0057 (0.57%) dan thit (0,78) < ttabel (1,98) tak berbeda; (2) tidak ada hubungan antara motivasi belajar ekstrinstik dengan hasil belajar kognitif biologi; hubungan tidak normal (nilai Lhitung 0.0562 < Ltabel 0.0850; hubungan tidak signifikan (Fhitung - 0.0036 < Ftabel 3.08; nilai persamaan Y= 83,52 + 0.0078 X2; nilai koefisien korelasi (r1y) = 0,025 (2,5%); nilai koefisien determinasi (KD/R12y) = 0,000625 (0.063%) dan thit (-0,25) < ttabel (1,98) tak berbeda; dan (3) tidak ada hubungan antara motivasi belajar intristik maupun ekstrinstik dengan hasil belajar kognitif biologi; nilai persamaan Y= 80,23 + 0.034 X1 + 0.0068 X2 ; nilai koefisien korelasi (r12y) = 0,078 (7,8%); Nilai koefisien determinasi (KD/R122y) = 0,0061 (0.61%) dan thit (0,809) < ttabel (1,98) tak berbeda; Hipotesis H0 diterima menolak Hi
THE EUROPEAN COMMUNITY CONTRADICTORY EXTERNAL BEHAVIOUR: THE PROMOTION OF INTEGRATION IN LATIN AMERICA IN THE LATE 1980s
Authors: Dongo Sueiro Mayte Anais 
Published: August 2022

The necessity of a policy towards the Latin American region was being discussed within the European Community (EC) in the 1980s. Within this debate, two relevant discourses can be traced. One highlighted the relevance of a Latin American interlocutor, which led to the EC and the Rio Group meetings in 1987. The other was against the opening of an interregional dialogue on the Latin American debt. These discourses had contradictory outcomes for the Latin-American interstate cooperation. One, improved it due to the recognition of a regional group; the other, disregarded the attempt to have a common Latin-American voice.El contradictorio comportamiento externo de la Comunidad Europea: la promoción de la integración latinoamericana a finales de los ochentaEn los ochenta, se discutía en la Comunidad Europea (CE) la necesidad de una política hacia la región latinoamericana. En ese debate, dos discursos pueden ser identificados. Uno hacía hincapié en la relevancia de un interlocutor, que llevó a las reuniones entre la CE y el Río Grupo en 1987. El otro discurso mostraba la oposición respecto a abrir un diálogo interregional sobre la deuda. Estos discursos tuvieron resultados contradictorios para la cooperación interestatal latinoamericana. Uno la mejoró debido al reconocimiento que se le dio a un grupo regional; el otro, ignoró el intento de tener una voz común latinoamericana.
Arte como experiência em uma Abordagem Triangular ou sobre o ensino de pintura em zigue zague
Authors: Lampert Jociele , Ruiz Raony Robson 
Published: August 2022

O presente artigo objetiva articular os conceitos da Abordagem Triangular da autora brasileira Ana Mae Barbosa com o de Arte como experiência do filósofo americano John Dewey, para analisar a prática docente como investigação realizada pelo/a artista professor/a pesquisador/a no contexto do ensino de pintura. Para tanto desenvolvemos partindo dos autores citados, uma pesquisa experimental que tenciona a prática docente e a prática artística, constituindo-se de metáforas e desafios, em meio ao zigue e zague na Abordagem Triangular.
La sustentabilidad desde la percepción de estudiantes: caso Preparatoria 47 de Texca, Guerrero
Authors: Brito Carmona Rosa María , Rodríguez Alviso Columba , Aparicio López José Luis , Beltrán Rosas Juana 
Published: August 2022

El objetivo de esta investigación fue evaluar la percepción de la sustentabilidad en estudiantes de una preparatoria ubicada en Texca, Guerrero. La metodología fue cuantitativa; se empleó la técnica de la encuesta mediante la opción de respuesta en escala de Likert a 79 participantes (34 hombres y 45 mujeres). El alcance fue exploratorio por ser un fenómeno poco estudiado. Los hallazgos más destacados muestran que, en la dimensión ambiental, 71 % de los estudiantes tiene conocimientos y actitudes favorables hacia el cuidado del medio ambiente; en la social, 72 % está muy satisfecho con el desempeño de sus docentes y las condiciones de equipamiento de las instalaciones escolares, aun y cuando consideran que se requieren mejores condiciones físicas para la realización de sus actividades; en el área económica, 61 % está de acuerdo con el pago de los aranceles institucionales, pero les gustaría saber cómo y en qué se invierten los recursos cobrados. Este estudio concluye con el reconocimiento de una adecuada percepción de los temas ambientales y de la sustentabilidad por parte de los docentes y estudiantes del nivel medio en una comunidad rural; sin embargo, también se reconoce que es necesario continuar con el desarrollo de procesos de capacitación con los docentes.