bluuebunny/crossref_metadata_2025_split huggingface dataset:
Populations of highly variable X-ray sources in theXMM–Newtonslew survey
Authors: Li Dongyue , Starling R L C , Saxton R D , Pan Hai-Wu , Yuan Weimin 
Published: March 2022

ABSTRACTWe present the identifications of a flux-limited sample of highly variable X-ray sources on long time-scales from the second catalogue of the XMM–Newton SLew survey (XMMSL2). The carefully constructed sample, comprising 265 sources (2.5 per cent) selected from the XMMSL2 clean catalogue, displayed X-ray variability of a factor of more than 10 in 0.2–2 keV compared to the ROSAT All Sky Survey. Of the sample sources, 94.3 per cent are identified. The identification procedure follows a series of cross-matches with astronomical data bases and multiwavelength catalogues to refine the source position and identify counterparts to the X-ray sources. Assignment of source type utilizes a combination of indicators including counterparts offset, parallax measurement, spectral colours, X-ray luminosity, and light-curve behaviour. We identified 40 per cent of the variables with stars, 10 per cent with accreting binaries, and at least 30.4 per cent with active galactic nuclei. The rest of the variables are identified as galaxies. It is found that the mean effective temperatures of the highly variable stars are lower than those of less variable stars. Our sample of highly variable AGN tend to have lower black hole masses, redshifts, and marginally lower soft X-ray luminosities compared to the less variable ones, while no difference was found in the Eddington ratio distributions. Five flaring events are tidal disruption events published previously. This study has significantly increased the number of variable sources in XMMSL2 with identifications and provides greater insight on the nature of many o f the sources, enabling further studies of highly variable X-ray sources.
The Magellanic Edges Survey – III. Kinematics of the disturbed LMC outskirts
Authors: Cullinane L R , Mackey A D , Da Costa G S , Erkal D , Koposov S E , Belokurov V 
Published: March 2022

ABSTRACT
We explore the structural and kinematic properties of the outskirts of the Large Magellanic Cloud (LMC) using data from the Magellanic Edges Survey (MagES) and Gaia EDR3. Even at large galactocentric radii (8° &lt; R &lt; 11°), we find the north-eastern LMC disc is relatively unperturbed: its kinematics are consistent with a disc of inclination ∼36.5° and line-of-nodes position angle ∼145° east of north. In contrast, fields at similar radii in the southern and western disc are significantly perturbed from equilibrium, with non-zero radial and vertical velocities, and distances significantly in front of the disc plane implied by our north-eastern fields. We compare our observations to simple dynamical models of the Magellanic or Milky Way system which describe the LMC as a collection of tracer particles within a rigid potential, and the Small Magellanic Cloud (SMC) as a rigid Hernquist potential. A possible SMC crossing of the LMC disc plane ∼400 Myr ago, in combination with the LMC’s infall to the Milky Way potential, can qualitatively explain many of the perturbations in the outer disc. Additionally, we find the claw-like and arm-like structures south of the LMC have similar metallicities to the outer LMC disc ([Fe/H] ∼ −1), and are likely comprised of perturbed LMC disc material. The claw-like substructure is particularly disturbed, with out-of-plane velocities &gt;60 km s−1 and apparent counter-rotation relative to the LMC’s disc motion. More detailed N-body models are necessary to elucidate the origin of these southern features, potentially requiring repeated interactions with the SMC prior to ∼1 Gyr ago.
Lense–Thirring effect on accretion flow from counter-rotating tori
Authors: Pugliese D , Stuchlík Z 
Published: March 2022

ABSTRACT
We study the accretion flow from a counter-rotating torus orbiting a central Kerr black hole (BH). We characterize the flow properties at the turning point of the accreting matter flow from the orbiting torus, defined by the condition uϕ = 0 on the flow toroidal velocity. The counter-rotating accretion flow and jet-like flow turning point location along BH rotational axis is given. Some properties of the counter-rotating flow thickness and counter-rotating tori energetics are studied. The maximum amount of matter swallowed by the BH from the counter-rotating tori is determined by the background properties. The fast spinning BH energetics depends mostly on BH spin rather than on the properties of the counter-rotating fluids or the tori masses. The turning point is located in a narrow orbital corona (spherical shell), for photons and matter flow constituents, surrounding the BH stationary limit (outer ergosurface), depending on the BH spin–mass ratio and the fluid initial momentum only. The turning corona for jet-like flow has larger thickness, it is separated from the torus flow turning corona and it is closer to the BH stationary limit. Turning points of matter accreting from torus and from jets are independent explicitly of the details of the accretion and tori model. The turning corona could be observable due to an increase of flow luminosity and temperature. The corona is larger on the BH equatorial plane, where it is the farthest from the central attractor, and narrower on the BH poles.
Unnecessary Routine Use of Mycobacterial Cultures in Patients With Periprosthetic Joint Infections
Authors: Golden Marjorie , Moffarah Anne Spichler , Kerantzas Christopher , Rubin Lee , O’Bryan Jane 
Published: March 2022

Abstract
Accurate diagnosis ensures appropriate therapy of periprosthetic joint infection (PJI). Since mycobacterial PJI is rare, routine testing is inappropriate. We reviewed hip and knee PJI at our institution over 28 months. Mycobacterial cultures were routinely sent with rare positivity. Mycobacterial cultures should be sent only when there is clinical suspicion.
Contamination Rate of Cryopreserved Umbilical Cord Blood Is Inversely Correlated with Volume of Sample Collected and Is also Dependent on Delivery Mode
Authors: Reuther Susanne , Floegel Kathrin , Ceusters Gunther , Albertini Veronica , Baran Jakub , Dempke Wolfram 
Published: March 2022

AbstractCord blood (CB) collected at birth has become a valuable stem cell source for hematopoietic stem cell transplantation (HSCT). However, the collection of umbilical cord blood always bears a risk of microbiological contamination, both in vaginal birth and in cesarean section. A total of 10 054 umbilical cord stem cell samples were successfully cryopreserved between 2010 and 2020, of which 783 (8%) samples were tested positive for bacterial contamination. Umbilical CB with a volume of less than 60 mL showed a bacterial contamination rate of 12%, and above 60 mL volume a rate of 6% was found demonstrating an inverse relationship between sample volume and contamination rate (correlation coefficient r = −0.9). The contamination rate was associated with the mode of delivery and showed a significantly higher contamination rate of 9.7% when compared with cesarean deliveries (1.4%). The 10-year period consistently shows an average contamination rate between 4% and 6% per year. It is conceivable that the inverse relationship between volume and contamination rate might be related to thinner veins although no scientific evidence has been provided so far. The lower contamination rate in cesarean sections appears to be related to the sterile operating setting. Overall, the rate of bacterial contamination varies and depends on the type of birth, the way of delivery, and probably the experience of the staff.
Dry Eye Symptom Severity and Visual Field Reliability Metrics
Authors: Camp Andrew S. , Long Christopher P. , Galor Anat , Yamane Maya , Proudfoot James A. , Weinreb Robert N. 
Published: March 2022

Précis:
Tracking failure frequency (TFF) increases with dry eye symptom severity and in the left eye.

Purpose:
Symptoms of dry eye disease are commonly encountered in glaucoma patients and can be exacerbated by topical glaucoma medications. Dry eye disease may influence the reliability of visual field (VF) tests and impact the accurate interpretation of the results.

Patients and Methods:
Patients at the Veterans Administration Medical Center San Diego completed the 5-item Dry Eye Questionnaire before VF testing between December 2018 and February 2019. VF reliability metrics were recorded for each patient. Standard reliability metrics included fixation losses, false positive, and false negative rates. Gaze tracking (GT) metrics included percent of stimuli with gaze deviations between 1 and 2 degrees, 3 and 5 degrees, 6 degrees or greater, and percent of stimuli with tracking failure (TFF). The use of glaucoma medications and artificial tears was also recorded.

Results:
A total of 494 patients completed the 5-item Dry Eye Questionnaire and VF testing. There was no association between dry eye symptom severity and standard reliability metrics or most GT metrics. However, TFF increased as dry eye symptom severity increased (P=0.015). TFF was also greater in the left eye, which was tested second (P=0.012); no other reliability metrics were related to laterality. Patients were more likely to use artificial tears with increased dry eye symptom severity (P<0.001), but there was no relationship between symptom severity and glaucoma medication use.

Discussion:
Dry eye symptom severity may influence the acceptable range or threshold of TFF when using GT metrics to determine VF reliability. Likewise, the acceptable range or threshold for TFF may be different between eyes.
Clinical and Prognostic Role of Noninvasive Hemodynamic Assessment in Left Ventricular Assist Device Carriers
Authors: Pidello Stefano , Frea Simone , Attisani Matteo , Lodo Vittoria , Baronetto Andrea , Savi Lucia , Cingolani Marco , Rinaudo Andrea , Boffini Massimo , Rinaldi Mauro , De Ferrari Gaetano Maria 
Published: March 2022

Persistence of heart failure symptoms or suboptimal hemodynamic is a frequent condition in LVAD carriers, associated with adverse outcome. Invasive hemodynamic optimization was associated with a better outcome. Our group recently validated an echocardiographic protocol to noninvasively assess hemodynamics of LVAD patients. Aim of this prospective study was to investigate its utility in clinical practice and its prognostic role.
From February 2016 to February 2019 fifty-five LVAD carriers (HVAD/HM3 34/21; age 61 ± 10 years, 89% males; INTERMACS profile at LVAD implantation ≤3 68%). A two-phased protocol was performed. First, the patient underwent clinical evaluation. Second, an echo-Doppler blinded to clinical data was performed. Clinical and echo-Doppler evaluation both identified patients with “optimal hemodynamic profile” (normal left and right estimated atrial pressures) versus other profiles. clinical evaluation overestimated the presence of an optimal profile compared with echo-Doppler (83% vs. 59%). The presence of overt heart failure identified patients with the highest risk of adverse outcomes (death or hospitalization for HF at 6 months: HR 15, 95% CI, 5.5–39, P < 0.001). An optimal profile by echo-Doppler was associated with a better outcome among patients without overt heart failure (death or hospitalization for HF at 6 months: HR 0.08, 95% CI, 0.01.5–0.64, P < 0.02). After echo-Doppler, the clinician modified treatment in 46 cases (37%). Noninvasive evaluation of hemodynamics by echo-Doppler adds significant prognostic information in LVAD patients without overt HF and is a valuable tool to tailor treatment in the outpatient follow-up of LVAD carriers.
Visual abstract: http://links.lww.com/ASAIO/A783
Small Intestinal Bacterial Overgrowth in Children: Clinical Features and Treatment Response
Authors: Peinado Fabregat Maria Isabel , Gardner Rebecca M. , Hassan Maheen A. , Kapphahn Kristopher , Yeh Ann Ming 
Published: March 2022

Objectives:
To characterize the population of children diagnosed with small intestinal bacterial overgrowth (SIBO) based on breath test (BT), correlate symptomatology, and describe SIBO treatments and treatment efficacy.

Methods:
A retrospective cohort study of pediatric patients seen at Stanford Children’s Health Gastroenterology Clinics from 2012 to 2018 who had a positive BT, defined by a rise in hydrogen by ≥20 ppm, a baseline hydrogen level ≥20 ppm, or a methane value ≥10 ppm. The main outcome was symptom resolution, defined as complete or partial improvement after a course of treatment. Absolute standardized differences and Chi-square tests were used to assess associations.

Results:
From 98 children, 54 met inclusion and did not meet exclusion criteria (53.7% female). Lactulose substrate was used for 41 (75.9%) patients, whereas glucose was used for 13 (24.1%). Complete or partial resolution of symptoms was achieved in 13 of 16 (81.2%) patients who received probiotics with or without antibiotics versus 21 of 31 (67.7%) patients treated with antibiotics alone (P = 0.524). Metronidazole versus rifaximin versus other antibiotics showed no significant difference in symptom resolution (12 (63.2%), 13 (76.5%), 7 (77.8%), respectively, P = 0.601).

Conclusion:
Seventy-two percent of patients experienced at least partial symptom relief after treatment. We did not find a strong correlation between specific symptoms and analyte elevation. There was no difference in effectiveness between metronidazole and rifaximin to treat SIBO symptoms. Further research needs to be done to determine effective treatments for SIBO in pediatrics.
Sex and Racial/Ethnic Differences in Within-Stay Readmissions During Inpatient Rehabilitation Among Patients With Traumatic Brain Injury
Authors: Oyesanya Tolu O. , Cary Michael P. , Harris Walker Gabrielle , Yang Qing , Byom Lindsey , Prvu Bettger Janet 
Published: March 2022

Objective
The aim of the study was to determine the association of sex and race/ethnicity with acute hospital readmissions (“within-stay readmissions”) during inpatient rehabilitation facility care versus patients discharged home without a within-stay readmission among traumatic brain injury patients.

Design
The study used a secondary analysis (N = 210,440) of Uniform Data System for Medical Rehabilitation data using multiple logistic regression.

Results
Within-stay readmissions occurred for 11.79% of female and 11.77% of male traumatic brain injury patients. Sex-specific models identified insurance, comorbidities, and complications factored differently in likelihood of within-stay readmissions among female than male patients but association of all other factors were similar per group. Within-stay readmissions differences were more pronounced by race/ethnicity: White, 11.63%; Black, 11.32%; Hispanic/Latino, 9.78%; and other, 10.61%. Descriptive bivariate analysis identified racial/ethnic patients with within-stay readmissions had greater days from traumatic brain injury to inpatient rehabilitation facility admission (White, 17.66; Black, 21.70; Hispanic/Latino, 23.81; other, 20.66) and lower admission cognitive and motor function. Factors differed across models predicting within-stay readmissions for race/ethnic groups; age, admission motor and cognitive function, complications, and length of stay were consistent across groups.

Conclusions
This study demonstrates disparities by race/ethnicity for inpatient rehabilitation facility within-stay readmissions among traumatic brain injury patients and factors predictive of this potentially preventable outcome by sex and race/ethnicity. Findings could inform care planning and quality improvement efforts for TBI patients.
Rehabilitation for Total Knee Arthroplasty: A Systematic Review
Authors: Konnyu Kristin J. , Thoma Louise M. , Cao Wangnan , Aaron Roy K. , Panagiotou Orestis A. , Bhuma Monika Reddy , Adam Gaelen P. , Balk Ethan M. , Pinto Dan 
Published: March 2022

Abstract
We sought to determine the comparative benefit and harm of rehabilitation interventions for patients who have undergone elective, unilateral TKA for the treatment of primary osteoarthritis. We searched PubMed, Embase, The Cochrane Register of Clinical Trials, CINAHL, PsycINFO, Scopus, and ClinicalTrials.gov from January 1, 2005 through May 3, 2021. We included randomized controlled trials and adequately-adjusted nonrandomized comparative studies of rehabilitation programs reporting performance-based, patient-reported, or healthcare utilization outcomes. Three researchers extracted study data and assessed risk of bias, verified by an independent researcher. The team assessed strength of evidence (SoE). Evidence from 53 studies RCTs suggests, various rehabilitation programs after TKA may lead to comparable improvements in pain, ranged of motion and activities of daily living. Rehabilitation in the acute phase may lead to increased strength but result in similar strength when delivered in the post-acute phase. No studies reported evidence of risk of harms due to rehabilitation delivered in the acute period following TKA; risk of harms among various post-acute rehabilitation programs appears comparable. All findings were of low SOE. Evaluation of rehabilitation after TKA needs a systematic overhaul to sufficiently guide future practice or research including the use of standardized intervention components and core outcomes.
Tongue Coating in COVID-19 Patients: A Case-Control Study
Authors: Wang Zhi Chun , Cai Xi Hong , Chan Jeremy , Chan Yi Yi , Chen Xiaotong , Cheng Ching Wan , Huang Donghui , Lao Bei-ni , Liu Xu-sheng , Lu Aiping , Wang Huixian , Zhang Helen , Zhang Xuebin , Zhang Shi Ping 
Published: March 2022

AbstractIt has been suggested that COVID-19 patients have distinct tongue features, which may help to monitor the development of their condition. To determine if there was any specific tongue coating feature in COVID-19, this study investigated the difference in tongue coating between COVID-19 subjects and subjects with other acute inflammatory diseases characterized by fever. Tongue images taken with smartphones from three age-matched groups, namely, COVID group (n=92), non-COVID febrile group (n=92), and normal control group (n=92), were analyzed by two blinded raters according to a tongue coating scoring scheme, which assessed the levels of thick fur, slimy or greasy fur, discolored fur and composite index of tongue coating. Compared with control, significant increases in all coating indexes were found in the COVID group (P<0.001), as well as in the non-COVID febrile group (P<0.001). However, no difference was observed between COVID and non-COVID febrile groups for all coating indexes measured. In COVID-19 subjects, their scores of coating indexes had weak but significant correlations with certain inflammatory biomarkers, including WBC and neutrophil - lymphocyte ratio. It is concluded that COVID-19 subjects have pathological tongue coating patterns that are associated with inflammatory responses, and these coating patterns can help to indicate the direction of disease development.
3D Bioprinted perfusable and vascularized breast tumor model for dynamic screening of chemotherapeutics and CAR-T cells
Authors: Dey Madhuri , Kim Myong Hwan , Nagamine Momoka , Dogan Mikail , Kozhaya Lina , Unutmaz Derya , Ozbolat Ibrahim T. 
Published: March 2022

AbstractDespite substantial advancements in development of cancer treatments, lack of standardized and physiologically-relevant in vitro testing platforms limit the rapid and early screening of anti-cancer agents. A major barrier in this endeavor, is the complex interplay between the tumor microenvironment and host immune response and lack of predictive biomarkers for clinical benefit. To tackle this challenge, we have developed a dynamic-flow based three-dimensionally (3D) bioprinted vascularized breast tumor model, responding to chemo and immunotherapeutic treatments. Heterotypic tumor spheroids, comprising metastatic breast cancer cells (MDA-MB-231), human umbilical vein endothelial cells (HUVECs) and human dermal fibroblasts (HDFs), precisely bioprinted at pre-defined distances from a perfused vasculature, exhibited tumor angiogenesis and cancer invasion. Proximally bioprinted tumors (∼100 μm) exhibited enhanced capillary sprouting, anastomosis to perfused vasculature and increased cancer cell migration as compared to distally bioprinted spheroids (∼500 μm). Proximally bioprinted tumors treated with varying dosages of doxorubicin for 72 h enabled functional analysis of drug response, wherein, tumors portrayed a dose-dependent drug response behavior with ∼70% decrease in tumor volume for 1 μM dose. Additionally, a cell based immune therapy approach was explored by perfusing HER2-targeting chimeric antigen receptor (CAR) modified CD8+ T cells for 24 or 72 h through the central vasculature. Extensive CAR-T cell recruitment to the endothelium and substantial T cell activation and infiltration in the tumor site, resulted in ∼70% reduction in tumor growth for high CAR treatment densities, after 72 h of treatment. The presented 3D model paves the way for a robust, precisely fabricated and physiologically-relevant 3D tumor microenvironment platform for future translation of anti-cancer therapies to personalized medicine for cancer patients.One Sentence SummaryA physiologically-relevant 3D bioprinted perfusable vascularized tumor model capable of dynamic screening of chemo and immunotherapeutics.
Adversarial attacks and adversarial robustness in computational pathology
Authors: Laleh Narmin Ghaffari , Truhn Daniel , Veldhuizen Gregory Patrick , Han Tianyu , van Treeck Marko , Buelow Roman D. , Langer Rupert , Dislich Bastian , Boor Peter , Schulz Volkmar , Kather Jakob Nikolas 
Published: March 2022

AbstractArtificial Intelligence (AI) can support diagnostic workflows in oncology by aiding diagnosis and providing biomarkers. AI applications are therefore expected to evolve from academic prototypes to commercial products in the coming years. However, AI applications are vulnerable to adversarial attacks, such as malicious interference with test data aiming to cause misclassifications. Therefore, it is essential for the use of AI-based diagnostic devices to secure them against such attacks before widespread use. Unfortunately, no resistant systems exist in computational pathology so far.To address this problem, we investigate the susceptibility of convolutional neural networks (CNNs) to multiple types of white- and black-box attacks. We demonstrate that both attacks can easily confuse CNNs in clinically relevant pathology tasks and impair classification performance. Classical adversarially robust training and dual batch normalization (DBN) are possible mitigation strategies but require precise knowledge of the type of attack used in the inference.We demonstrate that vision transformers (ViTs) perform equally well compared to CNNs at baseline and are orders of magnitude more robust to different types of white-box and black-box attacks. At a mechanistic level, we show that this is associated with a more robust latent representation of clinically relevant categories in ViTs compared to CNNs.Our results are in line with previous theoretical studies. We show that ViTs are robust learners in computational pathology. This implies that large-scale rollout of AI models in computational pathology should rely on ViTs rather than CNN-based classifiers to provide inherent protection against adversaries.