bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visible‐Light‐Driven One‐Pot Synthesis of Benzimidazoles, Benzothiazoles, and Quinazolinones Catalyzed by Scalable and Reusable Ba‐Doped CoMoO4 Nanoparticles Under Air Atmosphere
Authors: Abinaya Ramanjulu , Elavarasan Selvaraj , Binish B. , Mani Rahulan K. , Balasubramanian Kalpattu K. , Manokaran Kamaraj , Varathan Elumalai , Baskar Baburaj 
Published: December 2022

AbstractHerein we report a simple and efficient oxidative coupling of various aryl methyl amines with diverse coupling partners, such as o‐phenylenediamine (benzene‐1,2‐diamine), 2‐aminobenzenethiol and 2‐aminobenzamide, to synthesize the corresponding heterocycles using scalable and reusable heterogeneous catalysts under visible light irradiation. A systematic investigation led to the synthesis of benzimidazoles, benzothiazoles and quinazolinones under air atmosphere in very good to excellent yields. The strategy is atom economical and found to be tolerance towards different functional groups, and wide range of substrate scope. Furthermore, the methodology was demonstrated for its suitability on scale up and reusability. The density functional theory (DFT) calculations and the analysis of band structures of pristine and Ba doped CoMoO4 systems showed that the doping of Ba in place of Co improved the catalytic performance of the system.
Orphan crops: A genetic treasure trove for hunting stress tolerance genes
Authors: Kumar Brijesh , Singh Anil Kumar , Bahuguna Rajeev Nayan , Pareek Ashwani , Singla‐Pareek Sneh L. 
Published: December 2022

AbstractOrphan crops, also known as minor crops, smart foods, and superfoods, have attracted great attention recently because of their unique ability to grow in resource‐poor marginal lands, and under harsh environmental conditions without any intensive agricultural care. These crops possess inherent tolerance against different abiotic stresses such as drought, salinity, cold, and heat. Recent advancements in genomic resources and high‐throughput phenotyping platforms have provided opportunities to explore the untapped potential of orphan crops to identify novel gene source(s) and mechanism(s) for developing abiotic stress‐tolerant crops. Moreover, genomics‐assisted investigations into the various physiological and molecular mechanism(s) could provide useful insights into stress tolerance mechanisms in these plants. Nevertheless, translating the hidden power of the tolerant gene pools from the orphan crops into major staple crops for enhancing their stress tolerance while maintaining yield is a challenging task. The contemporary tools of genomics can be used to unravel the secret of stress tolerance in orphan crops and employ these untapped genes for tailoring stress‐tolerant crop varieties to ensure global food security in the era of climate change.
Clear cell mesotheliomas with inactivating VHL mutations and near‐haploid genomic features
Authors: Michal Michael , Kravtsov Oleksandr , Ross Jeffrey S. , Skanderová Daniela , Martínek Petr , Mosaieby Elaheh , Mata Douglas A. , Williams Erik A. , Hung Yin P. 
Published: December 2022

AbstractClear cell mesothelioma is uncommon and shows predominance of clear cells with resemblance to clear cell carcinomas. Clinicopathologic and molecular descriptions of clear cell mesothelioma remained limited. In this study, we identified an index patient with clear cell mesothelioma, confirmed by immunohistochemical and ultrastructural studies. Targeted next‐generation sequencing revealed the presence of an inactivating VHL mutation. We then systematically searched for VHL‐mutant mesotheliomas in a comprehensive genomic profiling database of 1532 mesotheliomas. Collectively, we identified a cohort of four VHL‐mutant clear cell mesotheliomas, including three peritoneal and one pleural tumors from three females and one male, with age range of 47–68 (median 63) years. Histologically, each tumor showed a microcystic to tubulopapillary architecture with prominent clear cells. By next‐generation DNA sequencing, each of the four clear cell mesotheliomas harbored inactivating VHL mutations, while lacking other alterations typical of mesotheliomas such as BAP1, NF2, SETD2, CDKN2A, CDKN2B, TP53, and PTEN. By using low‐pass whole genome sequencing on the index case and targeted next‐generation sequencing on the remaining three cases, we identified extensive loss of heterozygosity throughout the genome but consistently sparing chromosomes 5, 7, and 20, characteristic of genomic near‐haploidization. In summary, clear cell mesotheliomas were characterized by inactivating VHL mutations and genomic near‐haploidization and appeared to represent a distinct clinicopathologic and molecular category of mesotheliomas. Our findings implicate VHL in the pathogenesis of a subset of mesotheliomas, particularly those with clear cell morphology.
Impact of depth of invasion on local recurrence in R0 resected node‐negative oral tongue squamous cell carcinoma
Authors: Dang Rushil R. , Kim Jaegak , Qureshi Muhammad M. , Fazeli Shoreh Roghayeh , Zhao Qing , Noonan Vikki L. , Sundararajan Devaki , Salama Andrew , Truong Minh Tam 
Published: December 2022

AbstractBackgroundThis study evaluates the impact of depth of invasion (DOI) on local recurrence (LR) in node‐negative oral tongue squamous cell carcinoma (SCC).MethodsFifty‐one patients were retrospectively reviewed from an institutional database. Patients were evaluated for local control (LC). Cox‐proportional hazards modeling was used to calculate hazard ratios.ResultsThere were 84.3% T1/2 and 15.7% T3/4 classification tumors. The 3‐year overall survival rate was 97.9%. Local failure rate was 5.7% with a 3‐year LC of 93.6%. On Univariate analysis, increased hazard of LR was noted with each unit increase in DOI (HR 1.40, 95% CI 1.07–1.83, p = 0.014). Age, sex, T classification, margins ≥5 mm, lymphovascular invasion (LVI) and perineural invasion (PNI), and adjuvant treatment were not associated with LR. On Multivariate analysis, adjusting for age and adjuvant treatment, results for DOI remained significant (aHR 1.46, 95% CI 1.08–1.98, p = 0.013).ConclusionOn evaluation of our institutional dataset increasing DOI was associated with increased hazard of local recurrence with oral tongue SCC.
Lenalidomide treatment for recurrent adult T‐cell leukemia/lymphoma after allogeneic hematopoietic cell transplantation
Authors: Tanaka Takashi , Inamoto Yoshihiro , Ito Ayumu , Watanabe Mizuki , Takeda Wataru , Aoki Jun , Kim Sung‐Won , Fukuda Takahiro 
Published: December 2022

AbstractPatients with recurrent adult T‐cell leukemia/lymphoma (ATL) after allogeneic hematopoietic cell transplantation (allo‐HCT) have a dismal prognosis. We retrospectively evaluated the safety and efficacy of lenalidomide (LEN) in 11 consecutive patients with recurrent ATL after allo‐HCT. The median time from allo‐HCT to ATL recurrence was 111 days (range, 20–1476), and that from allo‐HCT to the initiation of LEN was 162 days (range, 43–1560). The median initial daily dose of LEN was 10 mg (range, 5–25), and the median duration of LEN treatment was 37 days (range, 3–1078). Three patients (27%) achieved complete response and two (18%) achieved partial response (PR). The rates of complete or PR according to the involved site were 57% for skin and 50% for nodal or extranodal lesions. With a median follow‐up of 1033 days (range, 601–1465) among survivors, the 1‐year probability of overall survival (OS) after ATL recurrence was 55%. Grade ≥3 toxicities included cytopenia (n = 4), superficial vein thrombosis (n = 1), and deep vein thrombosis (n = 1). Graft‐versus‐host disease (GVHD) newly developed in five patients (45%) and worsened in four patients (36%). The median duration from the initiation of LEN to GVHD onset or worsening was 5 days (range, 1–9). GVHD was manageable in all patients. Seven patients received mogamulizumab (MOG) for recurrent ATL before LEN treatment. The overall response rates to LEN were 57% in patients who had previously received MOG and 25% in those who had not. The 1‐year probabilities of OS after recurrent ATL were 71% in patients who had previously received MOG and 25% in those who had not. Although cytopenia and GVHD are common among patients with recurrent ATL after allo‐HCT, LEN may improve survival. Administering MOG before LEN may augment treatment efficacy in the allo‐HCT population.
‘When my mummy and daddy aren't looking at me when I do my maths she helps me’; Children can be taught to create imaginary companions: An exploratory study
Authors: Davis Paige E. , King Nigel , Meins Elizabeth , Fernyhough Charles 
Published: December 2022

AbstractSpontaneous imaginary companion (SIC) creation in childhood is a typical imaginative play behaviour associated with advanced sociocognitive skills; however, the direction of causality has not been established. To investigate this experimentally, researchers must determine whether children can create, on request, qualitatively equivalent imaginary companions (ICs) to those created spontaneously. We examined whether children could create ICs, and how these compared to SICs. Nine elementary school children were encouraged to create ICs in a 3‐month intervention. Accounts of elicited ICs were compared with an age‐matched sample of interviewees with SICs. Seven children maintained ICs for 6 months post intervention. Template analysis of IC interviews found four themes: Realistic Play, Multifaceted IC Mind, Utility of the IC, and Elicited IC Across Time. Analysis suggests elicited and SICs were similar in nature and utility, although intervention ICs tended to have animal rather than human appearances. Findings support the argument that children can be encouraged to create ICs similar to SICs.
Short-term hydromorphological and ecological responses of using woody structures for river restoration in a tailing-impacted tropical river
Authors: Furley Tatiana H. , Calado Sabrina Loise M. , Mendes Lucas B. , Chagas Katia R. , Andrade Douglas P. , Covre Barbiero Danielle , Alves Carlos Bernardo M. , Ivo Diógenis Belo Pedro , Ribeiro-Filho Paulo S. M. , Niencheski Luis Felipe H. 
Published: December 2022

Abstract
Gualaxo do Norte River (GNR), in southeastern Brazil, was impacted by iron ore tailings from the Fundão Dam rupture (November 2015). The deposition of tailings on the riverbed has changed the hydrogeomorphological characteristics of the GNR, resulting in a decrease in the diversity of physical habitats and ecological biodiversity. As part of the process of restoration and management of this damaged ecosystem, the river restoration project ReNaturalize was implemented to restructure the geomorphological characteristics and the physical habitat and to enhance the reestablishment of biota, mainly for macroinvertebrates and fishes. For this goal, 203 wooden structures, such as tree trunks, branches, and grass were installed in two sections of GNR (T6R and T7R), totaling 1.8 km long. The effectiveness of the project was evaluated by an assessment that followed a before and after and control and impacted (BACI) design. Upstream of each Restored reach there is a Control and a Reference reach. Four campaigns were carried out, two before and two after the restoration process. After 14 months of the woody installation, an increase in hydraulic retention in the restored reaches was observed (T6R—20.2%; T7R—63.5%), when compared with the Control reaches, which favored the accumulation of sediments (T6R—388 metric tons; T7R—396 metric tons). This enhanced the formation of natural tailings barriers and promoted the enrichment of substrate types (T6R—39.2%; T7R—43%). The benthic macroinvertebrate community showed an increase in the total abundance (T6—110%), including the most sensitive groups (T6R—124%; T7R—124%). For fish, the increase was up to 81.38% with hand nets capture, indicating the recruitment of juveniles, and the abundance and the biomass of some species were also higher (up to 100%) than the Control reaches. The results indicated that the Restored reach is already qualitatively and quantitatively better than the Control reach and similar to the Reference reach, indicating the success of the study. Integr Environ Assess Manag 2023;19:648–662. © 2022 SETAC
Longitudinal changes in term and preterm infant night wakings: The role of caregiver anxious‐depression
Authors: Lobermeier Michelle , Hicks Amanda , Staples Angela D. , Huth‐Bocks Alissa C. , Warschausky Seth , Taylor H. Gerry , Lukomski Angela , Brooks Judi , Lajiness‐O'Neill Renée 
Published: December 2022

AbstractChanges in infant night waking during the first year of life are associated with individual (e.g., prematurity) and family (e.g., caregiver psychopathology) factors. This study examined the association between infant night waking and caregiver anxious‐depressive symptoms during the first year of life in preterm and term infants. We considered between‐person differences and within‐person changes in caregiver anxious‐depressive symptoms in relation to changes in infant night waking from 2‐ to 9‐months. Racially (30.0% Black, 60.4% White, 9.5% multiracial/other) and socioeconomically (40.0% below median household income) diverse caregivers (N = 445) of full term (n = 258) and preterm (n = 187) infants were recruited from hospitals and clinics in two midwestern states. Caregivers completed measures of anxious‐depression and their infant's night waking at four sampling periods (2‐, 4‐, 6‐, and 9‐months). Infant night wakings declined from 2‐ to 9‐months. Between‐person differences were observed, such that caregivers with higher average anxious‐depressive symptoms or infants born full term reported more night wakings. Within‐person effects of caregiver anxious‐depressive symptoms were not significant. Caregiver anxious‐depression is closely associated with infant night wakings. By considering a caregiver's average severity of anxious‐depression, healthcare providers can more effectively plan infant sleep interventions. If caregiver anxious‐depressive symptoms are ameliorated, night wakings may also decrease.
Investigation of biological activities of various 1,2,3‐triazole compounds: Their effects on cholinesterase enzymes, determination of antioxidant capacity and antimicrobial activity
Authors: Almaz Züleyha 
Published: December 2022

Abstract1,2,3‐triazoles are pharmaceutically significant compounds that have attracted recent interest from medicinal chemists because of their important biological activities. Addressed herein, some 1,2,3‐triazoles were synthesized to investigate the inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, antioxidant capacity, and antimicrobial effect. The antioxidant profile of 1,2,3‐triazoles determined by varied bioanalytical antioxidant methods, including 2,2′‐azino‐bis (3‐ethylbenzthiazoline‐6‐sulfonic acid) (ABTS.+), 1,1‐diphenyl‐2‐picrylhydrazil (DPPH·), cupric ion (Cu2+) and ferric ion (Fe3+) ascorbic acid, butylated hydroxyanisole (BHA), and butylated hydroxytoluene (BHT) were used as the standard compounds. In addition, the antibacterial and antifungal activities of these compounds were investigated against seven bacteria and three fungal species using the hollow agar method. As a result of these studies, it was determined that compound 4 showed the best antimicrobial activity and antioxidant activity close to the standards. Inhibitory effects and kinetic studies of these molecules on cholinesterase enzymes were performed. According to the results obtained, compound 4 showed stronger AChE inhibition and compound 3 stronger BChE inhibition compared to other compounds. In kinetic studies, it was found that AChE showed noncompetitive inhibition by compound 4, and BChE showed competitive inhibition by compound 3.
Cancer detection during the COVID‐19 pandemic—Experiences in primary care and recommendations for the future
Authors: Siepman Van den Berg Marinde F. R. , Grant Matthew , van Erp Nicole , van Gils Carla H. , Muris Jean , Brandenbarg Daan , van Asselt Kristel M. , de Wit Niek J. , Helsper Charles W. ,   COVID and Cancer‐NL Consortium
Published: December 2022

AbstractBackgroundTo describe general practitioners (GPs) experiences with the impact COVID‐19 on the duration of cancer detection.MethodsCross‐sectional survey study among Dutch GPs.ResultsFifty‐eight GPs participated. During the first wave, COVID‐19‐related delays were experienced by 88%, 52%, and 67% of GPs in the contact‐seeking, primary care, and referral phases, respectively. GPs reported delays due to telehealth consultations, longer waiting times and patient's concerns of COVID infections and overburdening GPs.ConclusionsThe majority of GPs experienced delays in cancer diagnostic processes during the beginning of the COVID pandemic, which was most prominent in the timeliness in which patients sought GP care.
The natural killer cell‐associated rs9916629‐C allele is a novel genetic risk factor for fatal COVID‐19
Authors: Vietzen Hannes , Furlano Philippe L. , Traugott Marianna , Totschnig David , Hoepler Wolfgang , Strassl Robert , Zoufaly Alexander , Puchhammer‐Stöckl Elisabeth 
Published: December 2022

AbstractThe severity of COVID‐19 is associated with individual genetic host factors. Among these, genetic polymorphisms affecting natural killer (NK) cell responses, as variations in the HLA‐E‐ (HLA‐E*0101/0103), FcγRIIIa‐ (FcγRIIIa‐158‐F/V), and NKG2C‐ (KLRC2wt/del) receptor, were associated with severe COVID‐19. Recently, the rs9916629‐C/T genetic polymorphism was identified that indirectly shape the human NK cell repertoire towards highly pro‐inflammatory CD56bright NK cells. We investigated whether the rs9916629‐C/T variants alone and in comparison to the other risk factors are associated with a fatal course of COVID‐19. We included 1042 hospitalized surviving and 159 nonsurviving COVID‐19 patients as well as 1000 healthy controls. rs9916629‐C/T variants were genotyped by TaqMan assays and were compared between the groups. The patients' age, comorbidities, HLA‐E*0101/0103, FcγRIIIa‐158‐F/V, and KLRC2wt/del variants were also determined. The presence of the rs9916629‐C allele was a risk factor for severe and fatal COVID‐19 (p < 0.0001), independent of the patients' age or comorbidities. Fatal COVID‐19 was more frequent in younger patients (<69.85 years) carrying the FcγRIIIa‐158‐V/V (p < 0.006) and in older patients expressing the KLRC2del variant (p < 0.003). Thus, patients with the rs9916629‐C allele have a significantly increased risk for fatal COVID‐19 and identification of the genetic variants may be used as prognostic marker for hospitalized COVID‐19 patients.
Site formation processes at Cenjiawan (Nihewan Basin, North China): a case study on the structure of the Early Pleistocene archaeological record in lakeshore environments
Authors: DONGDONG  , PEI SHUWEN , XIE FEI , DE LA TORRE IGNACIO , DING XIN , YE ZHI 
Published: December 2022

ABSTRACTLakeshore environments offer an excellent opportunity to explore how early humans adapted to changing landscapes and environments. The Nihewan fluvio‐lacustrine sequence in North China contains one of the densest concentrations of Early Pleistocene Palaeolithic sites outside of Africa. Among these, the Cenjiawan site, dated at 1.1 Ma, draws attention due to the large number of stone tool refits. We present here Cenjiawan's sedimentary context, artefact spatial patterns, size distribution and taphonomic features, which are complemented by an experimental programme to better understand archaeological debitage size patterns, thus enabling a detailed analysis of formation processes at the site. The Cenjiawan assemblage is also interpreted in the light of its geographical and geological context, where a synsedimentary fault induced a minor topographic relief across the lacustrine lakeshore. This resulted in a shallow‐water setting in the down‐thrown hanging wall of the fault compartment, and a fluvial environment in the uplifted footwall. Our results indicate that Cenjiawan, situated in the hanging wall of the fault, underwent minimal disturbance, constituting a remarkable example of optimal preservation of archaeological assemblages in Early Pleistocene lakeshore environments.
TheCONSENSYSapproach: An instrument to supportCONtextual SENsitivityinSYStematicreviews
Authors: Bengough Theresa , Sommer Isolde , Hannes Karin 
Published: December 2022

AbstractContextual factors such as cultural values and traditions impact on implementation processes of healthcare interventions. It is one of the reasons why local stakeholders may decide to role out a programme differently from how it has originally been developed or described in scientific literature. This can result in different but most likely more context‐specific outcomes. Systematic reviews are considered important in answering what works, for whom and in which circumstances. They often include a section on implications for policymakers and practitioners, in which they discuss relevant options to engage with. Implementation sections are coloured by the cultural background, theoretical and disciplinary perspective of the reviewers formulating them. They do not necessarily consider local contexts in which the evidence needs to be applied, hence the recommendations may be too general to be useful. When policy makers and practitioners implement systematic review findings the evidence presented needs to be translated to their local context. We propose CONSENSYS, an instrument that facilitates the transfer from review evidence into practice. CONSENSYS contains 52 contextual factors categorised as either of ecological and socio‐cultural relevance or pitched as influencing actor. CONSENSYS is relevant for reviewers because it supports them in structuring and formulating context‐sensitive implications sections. It may also guide end‐users of systematic reviews in translating review evidence for use in local policies and practices. CONSENSYS is the first rigorously developed instrument that focusses on implications for policy and practice sections in systematic reviews.
Mixed cropping with duck co‐culture: an agroecological system to improve grain quality and farm profitability
Authors: Li Meijuan , Li Ronghua , Zhang Jiaen , Liu Shiwei , Hei Zewen , Wang Qi 
Published: December 2022

AbstractBACKGROUNDPrevious studies found that mixed cropping combined with duck co‐culture (MCDC) system could improve the efficiency of grain production and positively affect soil nutrient contents. However, the effects on grain quality, and profitable income have not been evaluated yet. In this study, a field experiment with four combinations of different rice varieties and ducks was conducted during both the early and late rice growing seasons.RESULTSThe field survey demonstrated that MCDC system significantly decreased the grain appearance of chalky rice rate and the chalkiness degree with an average of 56.82%, and 54.28%, respectively. Leaf SPAD value, photosynthetic rate, and aboveground dry weight were all improved in the MCDC and mixed‐cropping systems, relative to the mono‐cropping system. The net income obtained from the mono‐cropping, mixed cropping (no ducks), and MCDC (with ducks) systems (from grain and ducks' meat) was 581.2 USD ha−1 yr−1, 1001.8 USD ha−1 yr−1, and 5242.1 USD ha−1 yr−1 in both growing seasons, respectively.CONCLUSIONPlanting genetically diverse rice varieties and co‐culture with ducks increased rice growth rates, productivity and grain quality. The MCDC system would provide more ecological and economic benefits compared with the conventional mono‐cropping system. © 2022 Society of Chemical Industry.