bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amino Alcohols as Potential Antibiotic and Antifungal Leads
Authors: Baker Jennifer R. , Cossar Peter J. , Blaskovich Mark A. T. , Elliott Alysha G. , Zuegg Johannes , Cooper Matthew A. , Lewis Peter J. , McCluskey Adam 
Published: March 2022

Five focused compound libraries (forty-nine compounds), based on prior studies in our laboratory were synthesized and screened for antibiotic and anti-fungal activity against S. aureus, E. coli, K. pneumoniae, P. aeruginosa, A. baumannii, C. albicans and C. neoformans. Low levels of activity, at the initial screening concentration of 32 μg/mL, were noted with analogues of (Z)-2-(3,4-dichlorophenyl)-3-phenylacrylonitriles which made up the first two focused libraries produced. The most promising analogues possessing additional substituents on the terminal aromatic ring of the synthesised acrylonitriles. Modifications of the terminal aromatic moiety were explored through epoxide installation flowed by flow chemistry mediated ring opening aminolysis with discreet sets of amines to the corresponding amino alcohols. Three new focused libraries were developed from substituted anilines, cyclic amines, and phenyl linked heterocyclic amines. The aniline-based compounds were inactive against the bacterial and fungal lines screened. The introduction of a cyclic, such as piperidine, piperazine, or morpholine, showed >50% inhibition when evaluated at 32 μg/mL compound concentration against methicillin-resistant Staphylococcus aureus. Examination of the terminal aromatic substituent via oxirane aminolysis allowed for the synthesis of three new focused libraries of afforded amino alcohols. Aromatic substituted piperidine or piperazine switched library activity from antibacterial to anti-fungal activity with ((Z)-2-(3,4-dichlorophenyl)-3-(4-(2-hydroxy-3-(4-methylpiperazin-1-yl)propoxy)phenyl)acrylonitrile), ((Z)-2-(3,4-dichlorophenyl)-3-(4-(2-hydroxy-3-(4-(4-hydroxyphenyl)piperazin-1-yl)propoxy)-phenyl)acrylonitrile) and ((Z)-3-(4-(3-(4-cyclohexylpiperazin-1-yl)-2-hydroxypropoxy)-phenyl)-2-(3,4-dichlorophenyl)-acrylonitrile) showing >95% inhibition of Cryptococcus neoformans var. grubii H99 growth at 32 μg/mL. While (Z)-3-(4-(3-(cyclohexylamino)-2-hydroxypropoxy)phenyl)-2-(3,4-dichlorophenyl)-acrylonitrile, (S,Z)-2-(3,4-dichlorophenyl)-3-(4-(2-hydroxy-3-(piperidin-1-yl)propoxy)phenyl)acrylonitrile, (R,Z)-2-(3,4-dichlorophenyl)-3-(4-(2-hydroxy-3-(piperidin-1-yl)propoxy)phenyl)acrylonitrile, (Z)-2-(3,4-dichlorophenyl)-3-(4-(2-hydroxy-3-(D-11-piperidin-1-yl)propoxy)phenyl)-acrylonitrile, and (Z)-3-(4-(3-(4-cyclohexylpiperazin-1-yl)-2-hydroxypropoxy)-phenyl)-2-(3,4-dichlorophenyl)-acrylonitrile 32 μg/mL against Staphylococcus aureus.
Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial
Authors: Dorward Jienchi , Yu Ly-Mee , Hayward Gail , Saville Benjamin R , Gbinigie Oghenekome , Van Hecke Oliver , Ogburn Emma , Evans Philip H , Thomas Nicholas PB , Patel Mahendra G , Richards Duncan , Berry Nicholas , Detry Michelle A , Saunders Christina , Fitzgerald Mark , Harris Victoria , Shanyinde Milensu , de Lusignan Simon , Andersson Monique I , Butler Christopher C , Hobbs FD Richard 
Published: March 2022

BackgroundColchicine has been proposed as a COVID-19 treatment.AimTo determine whether colchicine reduces time to recovery and COVID-19-related admissions to hospital and/or deaths among people in the community.Design and settingProspective, multicentre, open-label, multi-arm, randomised, controlled, adaptive platform trial (PRINCIPLE).MethodAdults aged ≥65 years or ≥18 years with comorbidities or shortness of breath, and unwell for ≤14 days with suspected COVID-19 in the community, were randomised to usual care, usual care plus colchicine (500 µg daily for 14 days), or usual care plus other interventions. The co-primary endpoints were time to first self-reported recovery and admission to hospital/death related to COVID-19, within 28 days, analysed using Bayesian models.ResultsThe trial opened on 2 April 2020. Randomisation to colchicine started on 4 March 2021 and stopped on 26 May 2021 because the prespecified time to recovery futility criterion was met. The primary analysis model included 2755 participants who were SARS-CoV-2 positive, randomised to colchicine (n = 156), usual care (n = 1145), and other treatments (n = 1454). Time to first self-reported recovery was similar in the colchicine group compared with usual care with an estimated hazard ratio of 0.92 (95% credible interval (CrI) = 0.72 to 1.16) and an estimated increase of 1.4 days in median time to self-reported recovery for colchicine versus usual care. The probability of meaningful benefit in time to recovery was very low at 1.8%. COVID-19-related admissions to hospital/deaths were similar in the colchicine group versus usual care, with an estimated odds ratio of 0.76 (95% CrI = 0.28 to 1.89) and an estimated difference of −0.4% (95% CrI = −2.7 to 2.4).ConclusionColchicine did not improve time to recovery in people at higher risk of complications with COVID-19 in the community.
Highly disordered VO2 films: appearance of electronic glass transition and potential for device-level overheat protection
Authors: Wei Guodong , Fan Xiaofei , Xiong Yiang , Lv Chen , Li Shen , Lin Xiaoyang 
Published: March 2022

Abstract
In this work, the phase transition of a highly disordered amorphous VO2 film is studied. It is found that the electronic transport behavior follows the Arrhenius or Vogel–Tammann–Fulcher model, showing different thermal sensitivity under different thicknesses. Based on it, the concept of a prototype device with overheating protection capability is demonstrated. The results, reflecting the relationship between phase transition and structural disorder, open up a unique pathway to understand the metal insulator transition in strongly correlated electronic systems and to its functionality in electronic devices.
Penggunaan Media Game Berbasis Internet Pada Pelajaran IPS Menggunakan Aplikasi Quizizz
Authors: Syarifuddin Syarifuddin , Madian Madian 
Published: March 2022

<p><em>Aktivitas dalam pembelajaran terhadap siswa sekarang sudah kebanyakan memakai Handphone, semata adanya sekarang terhadap penyakit virus COVID-19 sudah terjadi mendunia serta Indonesia termasuk juga, siswa sekarang memakai handphone serta diperhatikan oleh orang tua siswa. Oleh itu handphone sangat bermanfaat dalam mengevaluasi pembelajaran yang dapat digunakan siswa, ada juga sesi baik dan buruknya. Jadi sangat diperlukan media untuk membuat anak-anak tidak bosan dalam pembelajaran. Quizizz adalah suatu aplikasi untuk evaluasi pembelajaran berupa game yang menyenangkan bisa main bersamaan. Kegunaan media Quizizz sangat diharapkan agar siswa tidak bosan dalam pembelajaran. Metodologi yang pakai adalah (R&amp;D) adapun langkahnya memakai model ADDIE, dan aplikasi yang digunakan adalah quizizz. Dari hasil yang didapat berbentuk nilai suatu kepantasan media game memakai quizizz yang pantas digunakan, karena akan terbantu nya guru dalam mengevaluasi pembelajaran melalui handphone.</em></p>
Implementasi Pembelajaran Qur’an Di Masa Pandemi Covid-19 Di Madrasah Ibtidayah Darussalim Bati Bati
Authors: Kumala Sari , Anshari Muhammad Iqbal , Sayemah Sayemah 
Published: March 2022

<p>Pada penelitian ini dengan bertujuan memahami Implmentasi Pembelajaran Qur’an di masa Pandemi Covid-19 di Madrasah Ibtidayah Darussalim Bati Bati serta mendeskripsikan apa saja Faktor yang mempengaruhi Implementasi Pembelajaran Qur’an di masa Pandemi Covid-19 di Madrasah Ibtidayah Darussalim Bati Bati. Penelitian ini memakai Kualittatif deskriptif dengan pendekatan Study kasus subjek Pembelajaran Qur’an, Koordinator Pembelajaran Al-Qur’an, Kepala Sekolah dan Wali kelas. Data yang dikumpulkan hal ini melewati hasil Observasi, Wawancara dan Dokumentasi, kemudian analisis data yang dipakai reduksi data,display, dan penarikan kesimpulan. Peneliti memakai trianggulassi sumber untuk mendapatkan keabsahan data. Berlandaskan hasil penelitian bisa disimpulkan maka Implementasi pembelajaran Qur’an di masa pandemi Covid-19 di MI Darussalim Bati-Bati dilakukan dengan beberapa kali perubahan 1) Perencanaan pembelajaran Qur’an di masa pandemi covid-19 dimulai dari perencanaan pembelajaran I online, perencanaan pembelajaran II online dan tatap muka dan perencanaan pembelajaran III tatap muka 2) Pelaksanaan pembelajaran Qur’an di masa pandemi covid-19 ada tiga kali pelaksanaan yaitu pelaksanaan I dilakukan dengan online, pelaksanaan pembelajaran II dilakukan dengan Online dan tatap muka 1 minggu sekali dan pelaksanaan pembelajaran dilakukan III dilakukan dengan Tatap muka, 3) Evaluasi pembelajaran Qur’an di masa pandemi covid-19 dilakukan evaluasi pembelajaran I dilakukan dengan evaluasi Pembelajaran online melewati pengiriman Video/rekaman suara, evaluasi pembelajaran II evalusi pembelajaran Qur’an dilakukan dengan online dan tatap muka dengan cara tatap muka atau hadir ke sekolah dan evaluasi III dilakukan dengan tatap muka. Yang mempengaruhi Implementasi Pembelajaran Qur’an di masa pandemi Covid-19 di MI Darussalim Bati-Bati yaitu:1) kebijakan dari pemerintah 2) Jaringan yang buruk 3) tanggapan dari guru 4) tanggapan dari orang tua siswa.</p>
Graph Based Deep Learning for Spatial Reuse Optimization in Dense WLAN Deployments
Authors: Azeez Stephen , Henna Shagufta 
Published: March 2022

<p>The IEEE 802.11ax standard is designed to provide high-efficiency WLAN operating in dense deployment, with a focus on increasing robustness and uplink transmission. IEEE 802.11ax aims to deliver self-configuration and self-adaptation capabilities for interference management techniques in dense deployments, to improve overall network conditions. The IEEE 802.11ax medium strives to intelligently use network allocation vectors (NAV), which block simultaneous transmission of neighboring co-existing access points from transmitting for a set period of time. Given an acceptable collision probability, this collision avoidance strategy tends to degrade network throughput and increase transmission delays since the medium is never completely exploited. In this paper, we propose affinityGNN, a graph neural network approach to actively optimize network co-existence transmission in a dense scenario. We introduce direct-affinityGNN which considers direct communications between IEEE802.11ax-compliant wireless systems and in contrast, skip-affinityGNN, which considers communication between IEEE802.11ax and Legacy devises by aggregating neural messages from direct and skip (two-hop) communicating neighbors in the dense wireless network deployment. Extensive experimental results not only show the superior performance of our proposed model over the state-of-the-art, but also demonstrate its potentially good interpretability and robustness for wireless network structure.</p>
Isolation and statistical optimization of rhodanese (a thiosulphate sulphur transferase) production potential of Klebsiella oxytoca JCM 1665 using response surface methodology
Authors: Itakorode Babamotemi Oluwasola , Okonji Raphael Emuebie 
Published: March 2022

Microorganisms are increasingly being used in cyanide bioremediation. Several organisms have been reported to thrive in cyanide contaminated wastewater due to their ability to produce cyanide detoxifying enzymes. However, to improve the production efficiency of these enzymes combinations of process variables need to be optimized. In this study, Klebsiella oxytoca JCM 1665 was isolated from industrial wastewater, identified by sequencing its 16S rRNA gene and subjected to rhodanese production using submerged fermentation. The conditions for production were optimized using response surface methodology (RSM). Central composite design was employed to evaluate the effects of three production parameters – peptone (1 – 5 %), KCN (0.1 – 0.5 %), and time of incubation (1 – 24 h). Second-order polynomial model was used to predict the response. Rhodanese activity in the experiments varied from 0.05 to 7.5 RU.mg-1. Under the optimum conditions of 4.35 % peptone, 0.4 % KCN and incubation time of 13 hr., the value for rhodanese yield was 7.810 U.mL-1. The R2 value for the model was 0.9925 (R2 = 0.9925). Also, the experimental values are in accordance with those predicted, indicating the suitability of the employed model and the success of RSM in optimizing the production conditions.
Method for Stability Analysis of a Wooden Coupling Bar under Dynamic Loading
Authors: Савин С. Ю. , Федорова Н. В. 
Published: March 2022

Постановка задачи . Целью исследования являлось развитие расчетной модели составных стержневых элементов из древесины при внецентренном сжатии для случая особого предельного состояния, а также разработка методики расчетного анализа таких конструкций с учетом нелинейного характера их деформирования (конструктивной, геометрической и физической нелинейности). Результаты. Построены аналитические выражения для вычисления жесткости приведенных по касательным модулям деформаций поперечных сечений цельного внецентренно сжатого элемента, эквивалентного элементу составного сечения с равномерно распределенными по длине связями сдвига и жесткими поперечными связями. Предложена методика и алгоритм расчета устойчивости деформированного состояния составных деревянных внецентренно сжатых стержневых элементов несущей системы здания при внезапном динамическом догружении, вызванном структурными изменениями в конструктивной системе. Выводы. Предложенная расчетная модель внецентренно сжатого составного стержня и алгоритм ее реализации применительно к расчету устойчивости деформированного состояния позволяют выполнять оценку сопротивления прогрессирующему обрушению деревянных конструкций зданий и сооружений при деградации сдвиговой жесткости их поперечных сечений.
Statement of the problem. The aim of the study was to develop a computational model of composite bar elements made of wood under eccentric compression for the case of a special limiting state as well as to develop a methodology for computational analysis of such structures taking into account the nonlinear nature of their deformation (geometric and physical nonlinearity). Results. In this work, analytical expressions are constructed for calculating the stiffness of the shear moduli of the cross sections of a solid eccentrically compressed element equivalent to an element of a composite section with shear links and rigid cross links evenly distributed along the length. A method for calculating the stability of the deformed state of composite wood eccentrically compressed rod elements of the load-bearing system of a building under sudden dynamic loading is proposed. Conclusions. The proposed calculation model of an eccentrically compressed composite bar and the algorithm for stability analysis allow one to assess the resistance to the progressive collapse of wooden members of buildings and structures with the degradation of the shear stiffness of their cross sections.
Selection of the Parameters of Piles Testing Using the Principles of the Wave Impact Theory
Authors: Целищев Г. А. , Золотозубов Д. Г. 
Published: March 2022

Постановка задачи. Рассматривается вопрос испытания свай методом, использующим волновую теорию удара и корреляции волновых характеристик с результатами статических испытаний. Динамические методы испытаний дешевле и быстрее, однако имеют меньшую точность по сравнению со статическими. В данном случае рассматривается ситуация, при которой на площадке уже проведен ряд статических испытаний, а дальнейший контроль несущей способности свай планируется осуществлять с помощью волновых методов. Предлагается коррелировать коэффициент демпфирования грунта исходя из данных статических испытаний. Результаты. По результатам исследования предложены методика и алгоритм корреляции данных волновых испытаний свай с результатами статических испытаний через подбор коэффициента демпфирования грунта, который при стандартном расчете является табличным эмпирическим коэффициентом. Выводы. Предложенный метод корреляции коэффициента демпфирования позволяет получить более точные данные о несущей способности свай по сравнению с использованием табличных значений. Данный подход применим только при наличии классической кривой распределения усилий во время волновых испытаний.
Statement of the problem. Consideration should be given to testing piles by a method using wave theory of impact and correlation of wave characteristics with static test results. Dynamic test methods are cheaper and faster, but less accurate than static ones. In this case, a situation is considered in which a number of static tests have already been carried out on site, and further control of the load-bearing capacity of the piles is planned to be carried out using wave methods. It is proposed to correlate the soil damping coefficient based on the data of static tests. Results. Based on the results of the study, a method and an algorithm for the correlation of data from wave tests of piles with static tests are proposed through the selection of the soil damping coefficient, which, in a standard calculation, is a tabular empirical coefficient. Conclusions. The proposed method for the correlation of the damping coefficient makes it possible to obtain more accurate data on the load-bearing capacity of piles in comparison with the use of tabular values. This approach is applicable only when there is a classical force distribution curve during wave tests.
Theoretical and Experimental Investigations of Pressure Loss Determination in Filter Elements of Coarse and Fine Gas Purification When Placed in One Body
Authors: Хомутов А. О. , Бирюков А. В. , Усачев А. П. , Куцыгина О. А. 
Published: March 2022

Постановка задачи. Надежная эксплуатация современных высокоточных систем редуцирования и управления потоками газа, расположенных в шкафных, блочных и капитальных газораспределительных пунктах, требует использования двухступенчатых цилиндрических установок для очистки газа, содержащих фильтры предварительной и тонкой очистки. Актуальной задачей является создание и научное обоснование применения экономически эффективных двухступенчатых устройств по очистке природного газа, размещаемых в газораспределительных пунктах, а также разработка аналитических методов расчета для определения потерь давления в фильтрующих элементах двухступенчатых цилиндрических установок и сроков их регенерации. Результаты. Приводится теоретическое и экспериментальное определение потерь давления в зависимости от степени засорения многослойного фильтрующего элемента механическими примесями. Выводы. Получены аналитические уравнения по определению потерь давления, отличающиеся от известных решений тем, что эффект засорения механическими примесями в многослойном фильтрующем полотне впервые представлен в виде суммы потерь давления на ряде чистых калиброванных сеток, расположенных одна за другой, с размерами ячеек каждой последующей сетки меньше, чем предыдущей.
Statement of the problem. Reliable operation of modern high-precision gas flow reduction and control systems located in cabinet, block and capital gas distribution points calls for the use of two-stage cylindrical gas purification plants containing preliminary and fine filters. An urgent task is the design and scientific justification for the use of cost-effective two-stage natural gas purification devices located at gas distribution points, as well as the development of analytical calculation methods for identifying pressure losses in the filter elements of two-stage cylindrical installations and the timing of their regeneration. Results. Theoretical and experimental identification of pressure losses depending on the degree of clogging of a multilayer filter element with mechanical impurities is provided. Conclusions. Analytical equations for determining pressure losses are obtained which differ from the known solutions in that the effect of clogging with mechanical impurities in a multilayer filter cloth is first presented as the sum of pressure losses on a number of clean calibrated grids located one after another, with the cell sizes of each subsequent grid less than the previous one.
Assessment of Physical and Mechanical Properties of Road Cement Concrete Prepared on Magnetic Water
Authors: Носов С. В. , Болдырева М. А. 
Published: March 2022

Постановка задачи. В последние годы в развитых странах растет спрос на строительство дорог и автомагистралей с жесткими дорожными одеждами, обеспечивающими удовлетворительную восприимчивость к повышающимся динамическим нагрузкам со стороны транспортных средств. Для дорожных цементобетонов открытым и актуальным остается вопрос эффективного и упрощенного применения операции омагничивания воды затворения цемента путем использования установок микроволнового излучения. При этом необходимо в первую очередь оценить изменчивость прочностных свойств цементобетона и подвижности цементобетонной смеси на омагниченной воде. Результаты. Исследованы показатели прочности дорожного цементобетона и подвижности цементобетонной смеси при использовании в процессе ее изготовления омагниченной воды посредством применения установки микроволнового излучения. В качестве исследуемых факторов были выбраны мощность электромагнитного излучения и время его воздействия при омагничивании воды. Применение теории математического планирования эксперимента позволило получить соответствующие закономерности в виде уравнений регрессии. Выводы. Применение омагниченной воды при производстве цементобетонной смеси показало проявление положительного эффекта в рамках обеспечения повышенной прочности дорожного цементобетона. При этом уменьшение ее подвижности требует пересмотра технологических режимов укладки и последующего уплотнения.
Statement of the problem. In recent years, in all civilized and highly developed countries, there has been a growing demand for the construction of roads and highways with rigid pavements that provide a satisfactory susceptibility to increasing dynamic loads from vehicles. For road cement concrete, the issue of effective and simplified application of the operation of magnetizing cement mixing water by using microwave radiation units remains relevant and urgent. In this case, it is necessary, first of all, to assess the variability of the strength properties of cement concrete and the mobility of the cement concrete mix on magnetized water. Results. The indicators of the strength of road cement concrete and the mobility of the cement concrete mixture when using in the process of its manufacture magnetized water through the use of a microwave radiation installation have been investigated. The studied factors were the power of electromagnetic radiation and the time of its exposure during the magnetization of water. The application of the theory of mathematical planning of the experiment made it possible to obtain the corresponding regularities in the form of regression equations. Conclusions. The use of magnetized water in the production of cement concrete mixture has shown a positive effect in terms of ensuring increased strength of road cement concrete. At the same time, a decrease in its mobility requires a revision of the technological modes of laying and subsequent compaction.