bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Simple Coupled Model of the Wind–Evaporation–SST Feedback with a Role for Stability
Authors: Karnauskas Kristopher B. 
Published: January 2022

Abstract
The wind–evaporation–SST (WES) feedback describes a coupled mechanism by which an anomalous meridional sea surface temperature (SST) gradient in the tropics evolves over time. As commonly posed, the (positive) WES feedback depends critically on the atmospheric response to SST anomalies being governed by a process akin to that argued by Lindzen and Nigam in 1987, and omits an alternative process by which SST anomalies modulate surface wind speed through vertical momentum mixing as proposed by Wallace et al. and Hayes et al. in 1989. A simple model is developed that captures the essential coupled dynamics of the WES feedback as commonly posed, while also allowing for momentum entrainment in response to evolving SST anomalies. The evolution of the coupled system depends strongly on which effects are enabled in the model. When both effects are accounted for in idealized cases near the equator, the initial anomalous meridional SST gradient grows over a time scale of a few months but is damped within one year. The sign and magnitude of the WES feedback depend on latitude within the tropics and exhibit hemispheric asymmetry. When constrained by realistic profiles of prevailing zonal wind, the model predicts that the WES feedback near the equator is stronger during boreal winter, while the domain over which it is positive is broader during boreal summer, and that low-frequency climate variability can also modulate the strength and structure of the WES feedback. These insights may aid in the interpretation of coupled climate behavior in observations and more complex models.

Significance Statement
Regional climate variability on time scales from months to decades, including El Niño, relies heavily on feedbacks between the atmosphere and the ocean in which some initial change in the environment is either amplified or damped over time. Several conceptual models for such feedbacks have been devised over the years to explain the coupled climate behavior seen in observations and computer simulations. A rather ubiquitous one is called the wind–evaporation–SST (WES) feedback, but the typical phrasing of it does not incorporate a potentially important influence of ocean temperature changes on the stability of the atmosphere above it. This study adds that effect to the WES feedback framework and examines climate variability through the lens of the augmented conceptual model.
BOREAL—A Fixed-Wing Unmanned Aerial System for the Measurement of Wind and Turbulence in the Atmospheric Boundary Layer
Authors: Alaoui-Sosse Sara , Durand Pierre , Medina Patrice , Pastor Philippe , Gavart Michel , Pizziol Sergio 
Published: January 2022

Abstract
An instrumentation package for wind and turbulence observations in the atmospheric boundary layer on an unmanned aerial vehicle (UAV) called BOREAL has been developed. BOREAL is a fixed-wing UAV built by BOREAL company, which weighs up to 25 kg (5 kg of payload) and has a wingspan of 4.2 m. With a light payload and optimal weather conditions, it has a flight endurance of 9 h. The instrumental payload was designed in order to measure every parameter required for the computation of the three wind components, at a rate of 100 s−1, which is fast enough to capture turbulence fluctuations: a GPS–inertial measurement unit (IMU) platform measures the three components of the groundspeed a well as the attitude angles; the airplane nose has been replaced by a five-hole probe in order to measure the angles of attack and sideslip, according to the so-called radome technique. This probe was calibrated using computational fluid dynamics (CFD) simulations and wind tunnel tests. The remaining instruments are a Pitot tube for static and dynamic pressure measurement and temperature/humidity sensors in dedicated housings. The optimal airspeed at which the vibrations are significantly reduced to an acceptable level was defined from qualification flights. With appropriate flight patterns, the reliability of the mean wind estimates, through self-consistency and comparison with observations performed at 60 m on an instrumented tower could be assessed. Promising first observations of turbulence up to frequencies around 10 Hz and corresponding to a spatial resolution to the order of 3 m are hereby presented.
Rare snake bite- A case report
Authors: Rathod Santosh Govind , Khan Afaq Ahmad , Geelani Sajad Ahmed , Roshan Reshma , Bhat Javid Rasool 
Published: January 2022

Snake bite is an acute life threating medical emergency and is included amonst neglected tropical diseases. 1 Every year in India 200,000 people bitten by snakes and >25% are fatal. 2 In Maharashtra, Konkan area, the green pit viper (Trimeresurus gramineus) is uncommon, though this snake has become more common. [ Figure 1 ]
BRCA1/BRCA2 mutation spectrum analysis in South Asia: a systematic review
Authors: Kharel Sanjeev , Shrestha Suraj , Yadav Siddhartha , Shakya Prafulla , Baidya Sujita , Hirachan Suzita 
Published: January 2022

Objective Breast cancer (BC) is the most common form of cancer among Asian females. Mutations in the BRCA1/ BRCA2 genes are often observed in BC cases and largely increase the lifetime risk of having BC. Because of the paucity of high-quality data on the molecular spectrum of BRCA mutations in South Asian populations, we aimed to explore these mutations among South Asian countries. Methods A systematic literature search was performed for the BRCA1 and BRCA2 gene mutation spectrum using electronic databases such as PubMed, EMBASE, and Google Scholar. Twenty studies were selected based on specific inclusion and exclusion criteria. Results The 185delAG (c.68_69del) mutation in exon 2 of BRCA1 was the most common recurrent mutation and founder mutation found. Various intronic variants, variants of unknown significance, large genomic rearrangements, and polymorphisms were also described in some studies. Conclusions The South Asian population has a wide variety of genetic mutations of BRCA1 and BRCA2 that differ according to countries and ethnicities. A stronger knowledge of various population-specific mutations in these cancer susceptibility genes can help provide efficient strategies for genetic testing.
Molecular mechanisms underlying the effect of diacerein on trichloroacetic acid–induced hepatic pre-neoplastic lesions in rats
Authors: Ibrahim Yasmine F , Refaie Marwa MM , Kamel Maha Y , Ahmed Sara M , Moussa Rabab A , Bayoumi Asmaa MA , Ibrahim Mohamed A 
Published: January 2022

Hepatocellular carcinoma (HCC) accounts for more than 5% of all human cancers. Diacerein (DIA), an interleukin (IL)-1β inhibitor, is used for the treatment of osteoarthritis. DIA is a potential anticancer drug acting on several protein targets in the process of apoptosis. The present study aimed to explore the molecular mechanisms underlying the effect of DIA in the treatment of trichloroacetic acid (TCA)–induced pre-neoplastic changes in rats. Rats were allocated into 5 groups and treated for 4 weeks. Group 1: control; received vehicle, Group 2: TCA group; received TCA (1 g/kg, orally for 5 days). Group 3: DIA-treated group; received TCA +DIA (50 mg/kg/day, orally, for 4 weeks). Group 4: positive control group; received TCA (1 g/kg, orally, for 5 days) + 5-fluorouracil (5-FU) (75 mg/kg) intraperitoneally (i.p.), for 4 weeks as a standard anticancer drug. Group 5: received TCA (1 g/kg, orally for 5 days) + DIA (50 mg/kg/day, orally, for 4 weeks) + 5-FU (75 mg/kg, i.p., for 4 weeks). Serum liver enzymes, oxidative stress parameters, inflammatory parameter (IL-1β), and angiogenesis marker vascular endothelial growth factor (VEGF) were assessed along with histopathological evaluation. An apoptotic marker as caspase-3 expression was measured by western blot analysis. Immunoexpression of proliferating cell nuclear antigen (PCNA) and hypoxia-inducible factor-1α (HIF-1α) was evaluated. Results and conclusion: The outcomes proved that at histological level, DIA ameliorated hepatic precancerous lesion via modulation of IL-1β–HIF-1α–VEGF pathway. Conclusion IL-1β mediates angiogenesis indirectly, as it has been shown to induce hypoxia-inducible factor-1α (HIF-1α) which upregulates VEGF.
Conceptualizing a Quantitative Measurement Suite to Evaluate Healthcare Teams
Authors: Paige John T. , Rogers Camille L. , Kerdolff Kathryn E. , Garbee Deborah D. , Bonanno Laura S. , Yu Qingzhao 
Published: January 2022

Background Current team assessment instruments in healthcare tend to involve rater-based evaluations that are susceptible to well-known biases. Recent advances in technology include portable devices to measure team-based activities. Consequently, the possibility exists to move away from rater-based assessments of team function by identifying quantitative measures to replace them. Aim This article aims to provide potential approaches to developing quantitative measurement suites involving large amounts of data to address the challenges of assessment presented by the complex nature of teamwork. Conclusion By addressing construct, measurement, and context components, we provide a practical approach to developing a suite to capture quantitative measurements that, through incorporation of social network analysis and aggregated other values, aligns with the Team Strategies & Tools to Enhance Performance and Patient SafetyTM (TeamSTEPPSTM) dimensions for fostering teamwork.
Facial Nerve Dysfunction After Mandibular Distraction Osteogenesis in Patients with Robin Sequence: A Systematic Review and Meta-Analysis
Authors: Kapoor Elina , Mantilla-Rivas Esperanza , Rana Md Sohel , Aivaz Marudeen , Duarte-Bateman Daniela , Escandón Joseph M. , Crowder Hannah R. , Manrique Monica , Rogers Gary F. , Oh Albert K. 
Published: January 2022

Objective Robin Sequence (RS), characterized by micrognathia, glossoptosis, and upper airway obstruction, is an increasingly recognized diagnosis. An effective surgical intervention is mandibular distraction osteogenesis (MDO). This study analyzes published evidence regarding facial nerve dysfunction (FND) associated with MDO. Design and Setting According to PRISMA guidelines, a systematic review was carried out with databases queried in June 2019 using MESH terms, or equivalent terms, as follows: “distraction osteogenesis” and “Robin Sequence”. A review of original Spanish and English articles, were included. Outcome measures included the prevalence of FND; the affected branches; the rate of permanent vs. transient FND; the use of an internal vs. external device; the daily distraction rate; and finally, the overall distraction length. Subsequently, a meta-analysis was conducted to collate results regarding the prevalence of FND and the factors associated with it. Results Of 239 unique studies identified, 19 studies with 729 patients met inclusion criteria; 52 patients developed FND after MDO. A random-effects meta-analysis yielded a pooled prevalence of FND of 6.40%, with moderately heterogeneous studies (I2 = 41%, τ2 = 0.006). Marginal mandibular nerve involvement was most commonly noted. Nine studies reported transient FND, six permanent, one both, and two unspecified. Internal distractors were used in 8 studies and external in 3 and both in 2. Distraction rate was 1.00 to 2.00 mm/day and total distraction length ranged from 13.00 to 22.3 mm. Sample size was the only parameter inversely associated with rate of FND (p = 0.04). Conclusion This analysis of FND associated with MDO for patients with RS demonstrates a lack of consistent documentation. MDO-associated FND does not appear to be uncommon, and permanent dysfunction can occur. This review underscores the importance of thorough documentation to elucidate the mechanism of FND.
Upper limb involuntary tremor reduction using cantilever beam TMDs
Authors: Gebai Sarah , Cumunel Gwendal , Hammoud Mohammad , Foret Gilles , Roze Emmanuel , Hainque Elodie 
Published: January 2022

Tuned mass dampers (TMDs) are proposed as a solution to reduce the involuntary tremor at the upper limb of a patient with postural tremor. The upper limb is modeled as a three-degrees-of-freedom rotating system in the vertical plane, with a flexion-extension motion at the joints. The measured extensor carpi radialis signal of a patient is used to excite the dynamic model. We propose a numerical methodology to optimize the parameters of the TMDs in the frequency domain combined with the response in the time domain. The objective function for the optimization of the dynamic problem is the maximum angular displacement of the wrist joint. The optimal stiffness and damping of the TMDs are obtained by satisfying the minimization of the selected objective function. The considered passive absorber is a cantilever beam–like TMD, whose length, beam cross-sectional diameter, and mass position reflect its stiffness for a chosen additional mass. A parametric study of the TMD is conducted to evaluate the effect of the TMD position along the hand segment, the number of TMDs, and the total mass of TMDs. The sensitivity of the TMD to a decrease of its modal damping ratio is studied to meet the range of stainless steel. TMDs are manufactured using stainless steel beams of the same length (9.1 cm) and cross-sectional diameter (0.79 mm), for which the mass (14.13 g) position is adjusted to match the optimal frequency. Three TMDs holding a mass of 14.13 g each cause 89% reduction in the wrist joint angular displacement.
Charles Bonnet syndrome as first manifestation of occipital infarction
Authors: Martínez-Sánchez Marta Isabel , Bolívar Gema 
Published: January 2022

Purpose To describe a case of Charles Bonnet syndrome as the first manifestation of occipital infarction in a patient with preserved visual acuity. Observations We report a 78-year-old man followed in our department with a two-month-long history of visual hallucinations based on the vision of flowers and fruits intermittently, being perceived as unreal images. Best-corrected visual acuity was stable in the follow-up time being 20/20 in the right eye and 20/25 in the left eye. Extraocular muscle function testing, pupillary reflexes, biomicroscopy, fundus and optical coherence tomography examinations did not reveal any interesting findings. In order to rule out occipital pathology, orbital-cerebral magnetic resonance imaging was performed, showing an image compatible with the chronic ischemic right occipital lesion. The patient was diagnosed with Charles Bonnet syndrome secondary to occipital infarction and neurology decided that no treatment was required. 24-2 and 10-2 visual field tests showed no remarkable alterations and Full-field 120 point screening test showed nonspecific peripheral defects. Hallucinations improved over the months, being described as not annoying and increasingly infrequent. Conclusions and Importance Charles Bonnet syndrome is a condition characterized by the presence of recurrent and complex visual hallucinations in patients with visual pathway pathologic defects. Visual acuity or visual field loss is not a requirement for diagnosis. Charles Bonnet syndrome should be suspected in all patients with non-disturbing visual hallucinations, even though they present good visual acuteness. It will be essential to perform complementary explorations to identify the underlying pathology that allows the starting of a correct treatment option.
Long-term outcomes in Primary congenital glaucoma, aniridia and anterior segment dysgenesis
Authors: Magan Tejal , Tanner Alexander , Fajardo-Sanchez Julia , Lim Kin Sheng , Goyal Saurabh , Rodrigues Ian , Amaya Luis , Trikha Sameer , Kulkarni Avinash , Hammond Christopher , Lascaratos Gerassimos , Yu-Wai-Man Cynthia 
Published: January 2022

Aim To determine the long-term outcomes of a cohort of complex patients with primary congenital glaucoma, aniridia and anterior segment dysgenesis. Methods Retrospective consecutive series between 1990–2021 in two UK tertiary centres: Guy's and St Thomas’ NHS Foundation Trust and King's College Hospital NHS Foundation Trust. We recorded the number and types of surgical and laser treatments along with preoperative and postoperative data, including intraocular pressures (IOP) and anti-glaucoma medications. Results A total of 41 eyes of 21 patients were included. Primary diagnoses were primary congenital glaucoma in 16 eyes (39.0%), aniridia in 14 eyes (34.2%), and anterior segment dysgenesis in 8 eyes (19.5%). Sixteen eyes (39.0%) had one or more glaucoma surgery or laser procedures for advanced glaucoma, and the long-term follow-up was 12.8 ± 3.6 years. There was a significant decrease in postoperative IOP (mmHg) at 3 months (16.5 ± 1.6; p = 0.0067), 6 months (18.7 ± 2.1; p = 0.0386), 12 months (18.6 ± 1.7; p = 0.0229), 3 years (14.7 ± 1.2; p = 0.0126), 5 years (15.5 ± 1.8; p = 0.0330) and 10 years (15.4 ± 2.3; p = 0.7780), compared to preoperatively (24.1 ± 2.6). Surgical success (complete and qualified) was 62.5%, 50.0%, 43.8%, 46.2%, 45.5% and 28.6% at 3 months, 6 months, 12 months, 3 years, 5 years and 10 years, respectively. There was no significant change in the number of anti-glaucoma drugs postoperatively ( p > 0.05). Four eyes (25.0%) had postoperative complications (hyphaema, hypotony) that resolved after conservative management. Conclusions Surgical management of these complex eyes with advanced glaucoma is challenging. Overall, the cohort had good surgical outcomes with a significant decrease in IOP by 36.1% after long-term follow-up.
Focal choroidal excavation associated with nonmelanocytic iris tumor
Authors: Montesel Andrea , Eandi Chiara M. , Zografos Leonidas 
Published: January 2022

Purpose To describe a unique unilateral association between an iris stromal tumor and a macular focal choroidal excavation. Case Description A 40-year old patient presented with a small iris tumor associated with a unilateral macular lesion disclosed during a routine ophthalmologic examination. The patient was asymptomatic and visual function was not affected. After clinical and instrumental evaluation, a diagnosis of nonmelanocytic undefined stromal tumor of the iris associated with macular focal choroidal excavation was made. The size and shape of the two lesions remained stable during a 7-year follow-up and the patient did not develop other signs. Conclusion The concurrent presence of a stromal iris tumor associated with focal choroidal excavation has never been reported. Further reports of this association are required in order to understand its exact pathogenesis.
Internal jugular to internal jugular vein bypass of symptomatic central vein obstruction
Authors: Carleton Jared , Chang Jason , (Richard) Pu Qinghua , Rhee Robert 
Published: January 2022

Introduction: Central venous obstruction (CVO) often arises among hemodialysis patients with upper extremity access due to a varying number of risk factors. While the true incidence of CVO in hemodialysis patients is unknown, it been reported in the range of 20%–40% in dialysis patients undergoing venograms. In the non-hemodialysis population, chronic central vein obstruction has a compensatory mechanism comprised of numerous collaterals along the chest wall, neck, and mediastinum. However, the presence of an AVF or AVG ipsilateral to a central venous stenosis or occlusion can overwhelm the collateral network due to the significantly elevated blood flow. This may result in severe and debilitating upper extremity and fascial swelling. While ligation results in almost instantaneous symptomatic relief, it does not address the patient’s underlying pathologic process and necessitates an additional access. As these patients continue to live longer, our strategies to manage these failing accesses are becoming increasingly complex. The goal of preserving existing access while correcting any symptoms is paramount. Previous case reports have documented various surgical options for preserving an existing access. Case presentation: Our patient is a 49-year-old female with hypertension and end-stage renal disease, on hemodialysis through a right arm arteriovenous (AV) fistula. She had a history of multiple AV fistulae creations in the past, all of which previously thrombosed. Several years after the creation of her most recent fistula, she developed severe throbbing headaches, right arm and facial swelling, right eye lacrimation, and blurry vision. AV fistula angiogram demonstrated right brachiocephalic vein chronic occlusion and endovascular revascularization through both trans-AVF and transfemoral approaches were attempted, but unsuccessful. Discussion: This case illustrates the success of the creation of an internal jugular-jugular vein bypass to maintain a right arm arteriovenous fistula, while at the same time, correcting the symptoms of a right brachiocephalic vein occlusion.
An exception to every rule; high velocity impact not always required for bilateral 1st rib fractures
Authors: Kutywayo Kudzayi H , Thekkudan Joyce , Tyson Nathan , Chowdhry Mohammed F 
Published: January 2022

Introduction First rib fractures are commonly reported in high velocity trauma. The neuromuscular sequelae that can ensue, not the physical disruption of the rib, necessitate thorough evaluation for such injuries. Methods We describe a case of a patient who sustained bilateral rib fractures following low-energy trauma.
Retrograde Recanalization of Occluded Radial Artery: A Single-Centre Experience and Literature Review
Authors: Shi Ganwei , Li Feng , Zhang Liuyan , Gong Chun , Xue Sheliang , Song Yanbin , Cai Gaojun 
Published: January 2022

Purpose: Radial artery occlusion (RAO) is one of the common complications after coronary intervention via the conventional radial artery approach. The purpose of the study was to explore the safety and feasibility of retrograde recanalization of the occluded radial artery via a distal radial artery (DRA) approach. Methods: Combined with the practice of our centre and a literature review, we summarized the procedure of retrograde recanalization of RAO, success rate, and complications. Results: A total of 14 of 15 patients with 15 pieces of occluded radial arteries were successfully recanalized via the DRA in our centre. In the 15 occluded vessels, 11 vessels (73.3%) had total occlusion and 4 vessels (26.7%) had functional occlusion. Four of 15 occluded vessels were acute occlusions. Two acute RAOs were only treated with aspiration via sheath, 11 RAOs with balloon angioplasty, and 2 RAOs with both, respectively. In 6 patients, cardiac catheterization was carried out via the DRA after recanalizing the RAO. A total of 10 studies reporting the results of recanalization of RAO via the DRA were systematically retrieved in the present study. In 3 case series, the number of cases was more than 5, and the success rate of recanalization was more than 85.7%. Two studies reported complications, including dissection in one case, hematoma in 2 cases, and pain in the forearm during angioplasty. Conclusions: Recanalization of the occluded radial artery via the DRA was safe and effective. When repeat cardiac catheterization was required, recanalization of the RAO and subsequent coronary angiography or intervention through the ipsilateral radial artery approach was feasible.