bluuebunny/crossref_metadata_2025_split huggingface dataset:
SNHG10/miR‐141‐3p/WTAP axis promotes osteosarcoma proliferation and migration
Authors: Ge Jiejie , Liu Meng , Zhang Yuchao , Xie Linsen , Shi Zhisong , Wang Guanghui 
Published: March 2022

AbstractLncRNAs have been suggested to participate in the growth and metastasis of cancer through a variety of molecular mechanisms. Recently, SNHG10, a newly discovered lncRNA, is reported to play a role of an oncogene in osteosarcoma (OS) genesis. Nonetheless, the mechanism underlying OS remains unclear. The present work found that SNHG10 expression increased within OS cells and tissues, while suppressing its expression decreased OS cell proliferation, migration, invasion, but increased their apoptosis. As for the mechanism, we confirmed that SNHG10 could bind to miR‐141‐3p, while the latter could bind to WTAP. SNHG10 upregulated WTAP through decreasing miR‐141‐3p expression. More importantly, SNHG10 deletion remarkably reduced proliferation, migration, and invasion of cells, but accelerated their apoptosis. However, when cells were subjected to miR‐141‐3p inhibitor cotransfection or overexpressed WTAP, these effects were partially recovered. In summary, this study suggested that the expression of SNHG10 markedly elevated within OS, and the SNHG10/miR‐141‐3p/WTAP axis facilitated OS progression.
Preparation, characterization and catalytic application of Zn‐based metal–organic framework catalyst for synthesis of 3,3‐(arylmethylene)bis‐1H‐indole derivatives
Authors: Rathod Vaishali N , Pawar Ganesh T , Gaikwad Suresh T , Lande Machhindra K 
Published: March 2022

AbstractBACKGROUNDA mesoporous zinc‐based pyridine‐2,5‐dicarboxylate metal–organic framework (Zn‐based MOF) catalyst was prepared by a solvothermal method. The catalytic potency of Zn‐based MOF for the one‐pot synthesis of 3,3‐(arylmethylene)bis‐1H‐indole derivatives was investigated.RESULTSVarious analytical techniques were used to characterize the physicochemical structure of Zn‐based MOF catalyst, including powder X‐ray diffraction, thermogravimetric analysis, scanning electron microscopy–energy‐dispersive X‐ray analysis, Fourier transform infrared spectroscopy and Brunauer–Emmett–Teller surface area analysis. Zn‐based MOF was then employed as a catalyst for the catalytic one‐pot transfer synthesis of 3,3‐(arylmethylene)bis‐1H‐indole derivatives. Optimizations of Zn‐based MOF catalyst in terms of effect of solvent and reaction time were investigated.CONCLUSIONSZn‐based MOF catalyst was synthesized by solvothermal treatment, characterized and used as a Lewis acid catalyst for the synthesis of biologically active 3,3′‐(arymethylene)bis‐1H‐indole derivatives. The catalyst offers notable benefits such as reusability of catalytic character, easy separation, nontoxicity, large pore size and providing excellent yield of 3,3′‐phenylmethylene‐1H‐indole derivatives. Zn‐based MOF was confirmed as containing tetragonal phase with large pore diameter, morphology looking like a spherical core and exhibiting no significance loss of catalytic performance when used in organic synthesis for three to four reaction runs. Thereby Zn‐based MOF was evidenced as showing excellent catalytic activity. © 2022 Society of Chemical Industry (SCI).
Comparison of Multiparametric and Fast MRI Protocols in Detecting Clinically Significant Prostate Cancer and a Detailed Cost Analysis
Authors: Alver Kadir Han , Yagci Ahmet Baki , Utebey Ayse Ruksan , Turk Nilay Sen , Ufuk Furkan 
Published: March 2022

BackgroundDue to the long acquisition time and high cost of multiparametric magnetic resonance imaging (mpMRI), biparametric and, more recently, fast prostate magnetic resonance imaging (fpMRI) protocols have been described. However, there is insufficient data about the diagnostic performance and cost of fpMRI.PurposeTo compare the diagnostic performances and cost analysis of fpMRI and mpMRI in clinically significant prostate cancer (csPCA).Study TypeRetrospective.PopulationA total of 103 patients (63 had csPCA) with a mean age of 66.83 (± 7.22) years were included.Field Strength/SequenceA 1.5‐T; T1‐ and T2‐weighted turbo spin‐echo imaging (T1WI and T2WI), echo‐planar diffusion‐weighted images, and dynamic contrast‐enhanced T1W imaging.AssessmentThree readers independently evaluated the fpMRI and mpMRI images in different sessions blinded to all patient information. Diagnostic performances of fpMRI and mpMRI were evaluated. Kappa coefficient (κ) was used to determine the interreader and intrareader agreement. A detailed cost analysis was performed for each protocol.Statistical TestsReceiver operating characteristics analysis, area under the curve (AUC), and κ test were used. Diagnostic performance parameters were also calculated.ResultsOf the 63 malignant index lesions (csPCA), 53/63 of those (84.1%) originated from the peripheral zone and 10/63 lesions (15.9%) originated from the transition zone. The AUC values for fpMRI were 0.878 for reader 1, 0.937 for reader 2, and 0.855 for reader 3. For mpMRI, the AUC values were 0.893 for reader 1, 0.94 for reader 2, and 0.862 for reader 3. Inter and intrareader agreements were moderate to substantial (κ range, 0.5–0.79). The total cost per examination was calculated as €12.39 and €30.10 for fpMRI and mpMRI, respectively.Data ConclusionsFast MRI protocol has similar diagnostic performance with mpMRI in detecting csPCA, and fpMRI can be considered an alternative protocol that could create a lower financial burden on health‐care systems.Level of Evidence4Technical Efficacy Stage6
Evaluation of the ASPEN guidelines for refeeding syndrome among hospitalized patients receiving enteral nutrition: A retrospective cohort study
Authors: Adika Edem , Jia Rongqing , Li Jianhua , Seres David , Freedberg Daniel E. 
Published: March 2022

AbstractBackgroundUntil recently, refeeding syndrome (RFS) has lacked standardized diagnostic criteria. This study sought to (1) determine whether RFS, as operationalized in the 2020 American Society for Parenteral and Enteral Nutrition (ASPEN) guideline definition, is associated with adverse clinical outcomes and (2) identify key risk factors for RFS.MethodsIn this retrospective cohort study, adults hospitalized from 2015 to 2019 were included if they were ordered for enteral feeding during hospitalization. Data were collected for up to 30 days, and RFS was operationalized as per the ASPEN 2020 guidelines as a ≥10% (corresponding to mild RFS), ≥25% (moderate), and ≥50% (severe) decline in prefeeding serum phosphorus, magnesium, or potassium. The mortality associated with RFS was assessed, and risk factors for RFS were identified using multivariable logistic regression modeling.ResultsOf 3854 participants, 3480 (90%) developed mild RFS. Thirty‐day mortality was higher in those without mild RFS (24%) than in those with mild RFS (18%) (P < 0.01). When RFS was reoperationalized as a 50% decline in electrolytes, 25% of patients developed RFS with a 20% 30‐day mortality. Risk factors for development of RFS included renal failure, elevated creatinine, and low platelets; additionally, prefeeding serum phosphorus level was strongly associated with development of RFS (adjusted odds ratio, 6.09; 95% confidence interval, 4.95–7.49 for those in the highest tertile of prefeeding phosphorus compared with the lowest).ConclusionThe ASPEN operationalization of RFS as a decline in baseline electrolyte values was not associated with death. Prefeeding serum phosphorus level strongly predicted severe RFS.
Assessment of the degree of degradation of sloping cropland in a typical black soil region
Authors: Zhang Shouhao , Sun Lei , Jamshidi Abdul Hakim , Niu Yong , Fan Zhaofei , Zhang Hongda , Liu Xia 
Published: March 2022

AbstractEvaluation of the degree of sloping cropland degradation in black soil regions of China is essential for the sustainable use of sloping cropland. However, the existing methods used to evaluate sloping cropland degradation are mostly based on point or management levels, and information at the regional scale is lacking. In this paper, we employed bibliometrics and frequency analysis to identify high‐frequency indicators to construct a total index set (TIS) for evaluating the degree of sloping cropland degradation. Soil measurement data from sloping cropland in typical black soil regions in Northeast China were used to construct a minimum data set (MDS). The TIS included 10 indexes: A‐horizon thickness, clay content, organic matter content, pH, slope gradient, ridge‐slope angle, gully density, bulk density, large water‐stable aggregate content, and cation exchange capacity. The first six of these were included in the MDS. Undegraded soil, mildly degraded soil, moderately degraded soil, severely degraded soil, and extremely severe degradation soil accounted for 11.6%, 28.7%, 34.1%, 22.9%, and 2.7% of investigated sampling plots, respectively. Ridge‐slope angle and slope gradient were the main factors affecting soil degradation. Soil degradation was mainly presented as worsening soil physicochemical characteristics and soil acidification. The significant positive correlation between ridge‐slope angle and soil degradation degree might indicate that the contour tillage management, which is usually adopted when slope gradient is steep, would lead to severer degradation level than the downslope tillage applied commonly where slope is gentle.
Meta‐analysis and traditional systematic literature reviews—What, why, when, where, and how?
Authors: Paul Justin , Barari Mojtaba 
Published: March 2022

AbstractMeta‐analysis is a research method for systematically combining and synthesizing findings from multiple quantitative studies in a research domain. Despite its importance, most literature evaluating meta‐analyses are based on data analysis and statistical discussions. This paper takes a holistic view, comparing meta‐analyses to traditional systematic literature reviews. We described steps of the meta‐analytic process including question definition, data collection, data analysis, and reporting results. For each step, we explain the primary purpose, the tasks required of the meta‐analyst, and recommendations for best practice. Finally, we discuss recent developments in meta‐analytic techniques, which increase its effectiveness in business research.
An update on nanoparticle usage in breast cancer imaging
Authors: Waller Joseph , DeStefano Kyle , Chiu Barbara , Jang Isabel , Cole Yonesha , Agyemang Charles , Miao Tyler , Shah Jaffer , Martin Clarissa , Umair Muhammad 
Published: March 2022

AbstractIntroductionThe objective of this literature review is to highlight both the recent promises of Nanoparticles (NPs) for breast imaging and potential solutions to the challenges that arise with using different types of NPs.MethodsWe searched for key terms on PubMed including NPs, MRI, CT, and contrast agent (CA). We selected 57 articles published from 2012 to 2020 and discussed NP such as nanocarriers, titanium oxide tubes, and carbon nanotubes, as well as gold, gold‐silver alloy, silver, magnetic, gadolinium dicarbide, allochroic, and calcium phosphate.ResultsWhile early studies on NPs investigated their ability to target breast cancer stem cells, as well as enable the visualization of metastasis and deliver therapeutic agents with minimal toxicity, newer particles demonstrate a greater multifunctionality of NPs than previously thought. In this review, we use existing research to demonstrate the surprisingly broad range of applications of NPs with regards to breast cancer and imaging, which includes activating immune cells, identifying protein signatures for early‐stage breast cancer, and ablating tumors through a laser irradiation‐triggered photothermal effect.ConclusionWith the multifunctionality of NPs in mind and the challenges associated with imaging breast tissue, specifically mammographically dense breast tissue, the current knowledge of NPs should be reviewed for potential use in mammograms.
An integrative review of the use of the concept of reassurance in clinical practice
Authors: Akyirem Samuel , Salifu Yakubu , Bayuo Jonathan , Duodu Precious Adade , Bossman Irene Fosuhemaa , Abboah‐Offei Mary 
Published: March 2022

AbstractAimTo synthesize evidence on the concept of reassurance in nursing practice.DesignIntegrative review.Review MethodPubMed, OVID MEDLINE, CINAHL and PsycINFO were searched from their inception to the 30 May 2020. The search results were screened. We assessed the quality of primary studies using the Mixed Method Appraisal Tool. Included studies were analysed using narrative synthesis. The review protocol was pre‐registered (PROSPERO‐CRD42020186962).ResultsThirty‐two papers out of the 2,771 search results met our inclusion criteria. The synthesis of evidence generated three intricate themes, namely “antecedents of reassurance,” “defining attributes of reassurance” and “outcomes of reassurance.” Emotional distress was the main antecedent of reassurance. The three sub‐themes identified under defining attributes of reassurance include self‐awareness, emotional connectedness and verbal and non‐verbal techniques. Ultimately, reposing the confidence of patients and their families in healthcare professionals and the care delivery process to enable them to overcome their challenges constitutes the outcomes of reassurance.
Evaluating peripheral intravascular catheter insertion, maintenance and removal practices in small hospitals using a standardized audit tool
Authors: Hoskins Alex , Worth Leon J , Malloy Michael J , Smith Mary , Atkins Sue , Bennett Noleen 
Published: March 2022

AbstractAimThe aim of this study was to evaluate clinical practice about peripheral intravenous catheter (PIVC) insertion, maintenance and removal in a cohort of Victorian hospitals.DesignA standardized PIVC audit tool was developed, and results from point prevalent surveys were conducted.MethodsHospitalized patients requiring a PIVC insertion were eligible for audit. Audit data submitted between 2015 and 2019 were extracted for the current study.Results3566 PIVC insertions in 15 Victorian public hospitals were evaluated. 57.6% of PIVCs were inserted in wards, 18.7% in operating theatres and 11.6% in Emergency Departments (ED). 45.2% were inserted by nurses and 38.2% by medical staff. The preferred site for insertion was the dorsum of the hand and forearm (58.8%). 22.6% did not report a visual infusion phlebitis score at least daily, and 48% did not document a daily dressing assessment. Reasons for PIVC removal included no longer required (63%) and phlebitis (4.8%). No bloodstream infections were reported.
Testing Function Focused Care for Acute Care using the Evidence Integration Triangle: Protocol description
Authors: Resnick Barbara , Boltz Marie , Galik Elizabeth , Kuzmik Ashley , Ellis Jeanette , Wells Chris , Zhu Shijun 
Published: March 2022

AbstractThis manuscript provides the protocol for a National Institute of Aging‐funded cluster randomized clinical trial that focuses on helping nurses in acute care to engage patients with dementia in physical activity while hospitalized using an approach referred to as function‐focused care. Physical activity is defined as bodily movement produced by skeletal muscles resulting in the expenditure of energy and includes functional tasks such as bathing and dressing, leisure activity, ambulation, and moderate and vigorous intensity physical activity such as dancing, bike riding, or walking upstairs. The development of Function Focused Care for Acute Care (FFC‐AC) was based on the Social Ecological Model and Social Cognitive Theory and includes four steps: (1) Environment and Policy Assessments; (2) Education; (3) Establishing Patient Goals; and (4) Mentoring and Motivating of Staff (all levels of nursing staff), Patients, and Families. Function‐focused care activities include motivating older patients to participate in bed mobility; personal care activities such as bathing, dressing, ambulating as they are able; and other types of physical activities. The integration of the intervention among the nurses on the units is guided by the Evidence Integration Triangle (EIT), which includes the participation of a stakeholder team and practical outcome measures. The intervention is therefore referred to as FFC‐AC‐EIT. In addition to describing the protocol developed to test the effectiveness and feasibility of FFC‐AC‐EIT, a description of ways to overcome some of the barriers and challenges that can be encountered with this study is provided.
Registration of ‘Ahring’ little bluestem
Authors: Springer Tim L. , Carr Brandon 
Published: March 2022

Abstract‘Ahring’ (Reg. no. CV‐16, PI 699123) little bluestem [Schizachyrium scoparium (Michx.) Nash] was selected for greater 7‐d seed germination at low water potential and superior field emergence. Two cycles of recurrent selection were used to develop Ahring from germplasm UO‐2. Cycle 1 consisted of germinating 3,500 open‐pollinated pure seed of germplasm UO‐2 (designated UO‐2 C0) in water of −0.8 MPa potential for 7 d. All spikelets that germinated in 7 d (∼250) were selected to create population UO‐2 C1. Cycle 2 selection was identical to Cycle 1 selection except that population UO‐2 C1 was used to create population UO‐2 C2. The 7‐d laboratory seed germination of Ahring was 17% higher than UO‐2 C0 in deionized water. Sixty days after planting, field emergence of Ahring (35%) was greater than either population UO‐2 C1 (32%) or UO‐2 C0 (22.0%) or the cultivars ‘Cimarron’ (32%) or ‘Aldous’ (27%). Thus, recurrent selection for increased seed germination in a negative water potential resulted in a little bluestem population capable of greater field emergence. Ahring little bluestem is useful for wildlife habitat, grazing, soil stabilization, water conservation, renewable energy, and horticultural landscapes in the south‐central and southern Great Plains of the United States. Ahring was cooperatively released by the USDA‐ARS and the USDA‐NRCS.
Organic fertilization regimes suppress fungal plant pathogens through modulating the resident bacterial and protistan communities
Authors: Sun Anqi , Jiao Xiaoyan , Ren Peixin , Yu Danting , Li Fangfang , Chen Qing‐Lin , Bi Li , He Ji‐Zheng , Hu Hang‐Wei 
Published: March 2022

AbstractIntroductionFungal plant pathogens are an emerging threat to economically important crop production worldwide and a significant risk to global food security. However, we have limited knowledge of how agricultural management practices drive the emergence and spread of pathogens within crop microbiomes and the underlying ecological mechanisms.Materials and MethodsWe characterized the profiles of potential fungal plant pathogens, as well as bacterial and protistan communities, in sorghum phyllosphere, root endosphere, and rhizosphere and bulk soils collected from a long‐term experiment with multiple inorganic and organic fertilization regimes.ResultsWe found contrasting patterns of fungal plant pathogens across the four sorghum–soil compartments and that organic fertilization regime significantly reduced the diversity and proportions of fungal plant pathogens in rhizosphere and bulk soils. We further found that the changes in fungal plant pathogens were driven more by resident bacterial and protistan communities than by soil physicochemical parameters. There was a significantly negative relationship between the diversity of fungal plant pathogens in the rhizosphere and bulk soils with sorghum yield and protein contents. Structural equation modeling revealed that long‐term organic fertilization regimes contributed to the suppression of fungal plant pathogens mainly through modulating the resident bacterial and protistan communities.ConclusionThese findings advance our understanding of the responses of fungal plant pathogens in crop microbiomes to fertilization regimes, with implications for more targeted strategies to manage the impacts of fungal pathogens on plant health and economic losses.
Identification of alpha‐Synuclein Disaggregator from Camellia sp. Insight of Molecular Docking and Molecular Dynamics Simulations
Authors: Vats Sheetal , Kondabala Rajesh , Saxena Sanjai 
Published: March 2022

AbstractMisfolded protein formation and aggregation are the central hallmarks for various neurodegenerative disorders. When it comes to Parkinson's disease (PD), alpha‐synuclein (α‐syn) is the culprit protein. The presence of α‐syn protein in lewy bodies and lewy neurites confirmed its presence in the occurrence of PD. The protein is natively present in the soluble monomeric forms, but certain factors such as oxidative stress convert the structure into insoluble oligomeric formats. This study focuses on the inhibitory effects of various antioxidant compounds on α‐syn oligomerization. We had collected the list of compounds present in the Camellia sp. plant. Using a computational approach, we found the potential interaction sites between the antioxidant compounds and α‐syn using a computational approach. Molecular docking and simulation studies suggest that the compound Theaflavin‐3‐3‐digallate shows best interactions with −7.1 kcal/mol and can reduce the alpha‐sheet structure of α‐syn structure to loop region.
Epoxy Vitrimer Based on Temperature‐Responsive Pure Organic Room Temperature Phosphorescent Materials
Authors: Wu Peng , Lou Lingyun , Xu Tianqi , Zhao Jianming , Hai Mingtan , Wang Dong , Cao Hui , He Wanli , Yang Zhou 
Published: March 2022

AbstractPure organic room temperature phosphorescent (RTP) materials are introduced to polymer matrices in recent researches for their attractive properties like mechanical character, low cost, facile fabrication and so on. Besides, polymers are considered to provide a rigid environment for phosphors to reduce nonradiative pathways and achieve efficient RTP emission. Vitrimers are new thermosetting polymers with dynamic covalent bond networks and temperature‐depended topology structure changes. Herein we report a rational design strategy for tailoring intermolecular interactions to enhance room temperature phosphorescence from purely organic materials in amorphous vitrimer matrices at ambient conditions. Unlike conventional polymer‐based phosphorescent materials, vitrimer matrices show not only rigid environment and optical transparency but thermal dynamic characteristics. A temperature‐responsive phosphorescent system of small phosphor DTPA‐CZ and vitrimer matrices is obtained, with a phosphorescence lifetime of 1.025 s and a photoluminescence efficiency up to 78.7 %.
Using Multi‐Level Correlation Information to Identify Amyloidogenic Peptides
Authors: Zou Hongliang , Zhan Chun 
Published: March 2022

AbstractIn recent years, more and more researchers draw their attention on exploring the characteristics of peptides. This study focused on identifying amyloidogenic peptides, since prior works reported that amyloidogenic peptides may keep a close relationship with neurodegenerative disease. To investigate this issue, we collected peptide sequences from Pep424 dataset. Fifty classes of physicochemical (PC) properties were employed to encode samples. Then, Pearson's correlation coefficient (PCC) was used to capture the correlation information among distinct PC properties. After that, we adopted the least absolute shrinkage and selection operator (LASSO) algorithm to select these most discriminative features. Next, these selected features were fed into support vector machine (SVM) for identifying amyloidogenic peptides. An accuracy of 89.62 % was obtained in jackknife test. A significant improvement was achieved by the proposed method, as compared with the state‐of‐the‐art predictors. It means that our method is effective and competitive in exploring amyloidogenic peptides field. We provide the dataset and Matlab codes for academic use, which can be available at https://figshare.com/articles/online resource/iAMY/17371877.