bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of pretreatment serum albumin−globulin ratio in urothelial carcinoma: A systematic review and meta-analysis
Authors: Xia Zhongyou , Fu Xueqin , Li Jinze , Wu Ji , Niu Chao , Xu Yulai , Wang Hao , Yuan Xinzhu , Tang Lingtong 
Published: August 2022

ObjectiveTo evaluate whether pretreatment albumin−globulin ratio (AGR) can be used as a biomarker for predicting the prognosis of patients with urothelial carcinoma (UC).MethodsWe systematically searched PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Google Scholar and Cochrane Library; the search time was up to May 2022. Stata 16.0 was used for data processing and statistical analysis.ResultsWe identified 12 studies with 5,727 patients from 317 unique citations during the meta-analysis. Our results suggested that a low AGR before treatment was significantly associated with poor overall survival (OS) [hazard ratio (HR) = 1.99, 95% confidence interval (CI) = 1.45-2.75, P &lt; 0.001], cancer-specific survival (CSS) [HR=2.01, 95% CI = 1.50-2.69, P &lt; 0.001] and recurrence-free survival (RFS) [HR=1.39, 95% CI = 1.12-1.72, P = 0.002]. Furthermore, we defined different subgroups according to ethnicity, cancer type, cut-off value, sample size and stage. Similar prognostic outcomes for OS and CSS were observed in most subgroups. However, for subgroup of stage, the low pretreatment AGR only predicted the poor survival of patients with non-metastatic UC.ConclusionOur meta-analysis revealed that the AGR before treatment could be used as a predictive biomarker to indicate the prognosis of UC patients during clinical practice, especially in patients with non-metastatic UC.
Discharge against medical advice among infants with 24–31 weeks’ gestation admitted to Chinese neonatal intensive care units: A multicenter cohort study
Authors: Xiu Wenlong , Bai Ruimiao , Gu Xinyue , Jiang Siyuan , Zhang Baoquan , Ding Ya , Wang Yanchen , Liu Ling , Sun Jianhua , Cao Yun , Zhou Wenhao , Lee Shoo K. , Li Zhankui , Yang Changyi 
Published: August 2022

BackgroundPrevious studies demonstrated high rates of discharge against medical advice (DAMA) among very preterm infants (VPIs) in China.ObjectivesThe aim of this study was to investigate the concurrent incidence, variation, and predictors of DAMA, along with the effect of DAMA on mortality of VPIs in China using data from the Chinese Neonatal Network (CHNN).MethodsAll infants born at 24–31 completed weeks’ gestation and admitted to 57 CHNN neonatal intensive care units (NICUs) in 2019 were included for this cohort study, excluding infants with major congenital anomalies. Patient information was prospectively collected using the CHNN database. Multivariable log-linear regression analysis was used to assess the association of perinatal factors and DAMA.ResultsA total of 9,442 infants born at 24–31 completed weeks’ gestation and admitted to 57 CHNN participating sites in 2019 were included in the study. Overall, 1,341 infants (14.2%) were discharged against medical advice. Rates of DAMA decreased with increasing gestational age (GA), and infants with lower GA were discharged earlier. DAMA infants had significantly higher rates of necrotizing enterocolitis, severe brain impairment, and bronchopulmonary dysplasia than non-DAMA infants. A total of 58.2% DAMA infants were predicted to die after discharge. The attributable risk percentage of mortality among DAMA infants was 92.4%. Younger maternal age, lower gestational age, small for gestational age, and Apgar score ≤3 at 5 min were independently associated with an increased risk of DAMA, while infants with antenatal steroids were less likely to be DAMA.ConclusionThe rate of DAMA in preterm infants between 24 and 31 weeks’ gestation remained high in China with a significant impact on the mortality rates. Continuous efforts to reduce DAMA would result in substantial improvement of outcomes for VPIs in China.
Case report: A fatal outcome from co-infection of COVID-19 and dengue in the western region of Jeddah, Saudi Arabia
Authors: Al-Nazawi Ashwaq M. , Al-Zahrani Ali A. , Qadir Anjum , Alghamdi Rana , Tambo Ernest , Alsahafi Abdullah 
Published: August 2022

IntroductionCo-infection of coronavirus disease 2019 (COVID-19) and dengue may coexist, as both viruses share similar laboratory and clinical features, making diagnosis and treatment challenging for health care professionals to prescribe, negatively impacting patient prognosis, and outcomes.Results and discussionsBoth cases were positive for PCR and X-ray laboratory investigation at clinical examination, confirming COVID-19 and dengue co-infection, admission, and better management in referral hospitals are presented and discussed. The timeline provides detailed cases of situational analysis and the medical actions taken, as well as the outcomes.ConclusionBoth co-infection cases' (patients) health conditions had a poor prognosis and diagnosis and ended with undesired outcomes. Scaling up dual mosquito-vector linked viral diseases surveillance in understanding the transmission dynamics, early diagnosis, and the timely and safe monitoring of case management in clinical and hospital settings nationwide is paramount in curbing preventable co-infections and mortality.
Resensitization of Fosfomycin-Resistant Escherichia coli Using the CRISPR System
Authors: Walflor Haniel Siqueira Mortagua , Lucena Aline Rodrigues Castro , Tuon Felipe Francisco , Medeiros Lia Carolina Soares , Faoro Helisson 
Published: August 2022

Antimicrobial resistance is a public health burden with worldwide impacts and was recently identified as one of the major causes of death in 2019. Fosfomycin is an antibiotic commonly used to treat urinary tract infections, and resistance to it in Enterobacteriaceae is mainly due to the metalloenzyme FosA3 encoded by the fosA3 gene. In this work, we adapted a CRISPR-Cas9 system named pRE-FOSA3 to restore the sensitivity of a fosA3+ Escherichia coli strain. The fosA3+ E. coli strain was generated by transforming synthetic fosA3 into a nonpathogenic E. coli TOP10. To mediate the fosA3 disruption, two guide RNAs (gRNAs) were selected that used conserved regions within the fosA3 sequence of more than 700 fosA3+ E. coli isolates, and the resensitization plasmid pRE-FOSA3 was assembled by cloning the gRNA into pCas9. gRNA_195 exhibited 100% efficiency in resensitizing the bacteria to fosfomycin. Additionally, the edited strain lost the ampicillin resistance encoded in the same plasmid containing the synthetic fosA3 gene, despite not being the CRISPR-Cas9 target, indicating plasmid clearance. The in vitro analysis presented here points to a path that can be explored to assist the development of effective alternative methods of treatment against fosA3+ bacteria.
Fertility control impact of the aerial parts Ferula tingitana L. via alteration of hypothalamic-pituitary-gonadal axis responses of female Wistar rats
Authors: El Sayed Abeer M. , El ghwaji Waleed , Youseif Zeinab M. , El-Deeb Kadriya S. , ElSayed Aly M. 
Published: August 2022

Ferula tingitana L. has been reported for abortive and\or menstruation inducing properties. However, its contraceptive effect has never been deliberately evaluated. Furthermore, no inclusive chemical profiling of its extract was recorded. Many Ferula species were known for their effects on the oestrogenic rhythm. During our drug discovery from natural sources F. tingitana L. growing in Libya was selected for evaluation of its contraceptive effect. To evaluate the hormonal effects and bioactive molecules of F.tingitana ethanol extract of aerial parts (EtOH) using in vivo experimental model. Adult female albino rats were divided equally into 4 groups (n=6). One group received distilled water for 14days, 2nd ,3rd and 4th groups received orally the tested extract at a daily dose of 100, 200 and 300 mgkg-1 b.wt. for 14 days, respectively. The administration lasted for 14 days (2 weeks) at 9 A.M. Rats body and uterus weight were measured. They fasted overnight and then anaesthetized through a diethylether exposure and blood samples were collected through the ocular puncture. Blood was centrifuged to obtain clear sera for hormonal assay. The serum was subjected by ELISA method for assessment of follicle stimulating hormone (FSH), luteinizing hormone(LH), estradiol(E2)and progesterone (P4) levels. Biochemical estimations of total cholesterol (TC), triglycerlide(TG) and glucose(Glu) level were measured. GC/MS of the lipoidal profile along with HPLC analysis of the phenolic contents were carried out. EtOH and its successive soluble fractions were subjected for chromatographic analysis. The results displayed significant decrease in levels of FSH, LH, E2 and P4 of adult female Wistar rats. Significant decline in biochemical serum level of TC, TG and Glu were observed. Sesquiterpene daucol, linolenic acid, caffeic acid and hesperidin were the main identified phytoconstituents. CC of EtOH afforded 5 compounds were identified as β-sitosterol 1, colladonin 2, scopoletin 3, caffeic acid 4, 1-(3,4-dihydroxycinnamoyl) cyclopentane-2`,3`-diol 5. It was concluded that sesquiterpene coumarins as the significant phytoconstituents of EtOH may revealing adverse effect on the menstruation, ovulation of follicles and consequently may impair fertility. EtOH evidenced a hypoglycemic and hypocholesterolemic effects.
Current Global Warming Prevention in Islamic Perspective: Research Review
Authors: Abdul manan Abdul manan cheema , Kamran Dr.Malik , Shaikh Dr.Muhammad Ali 
Published: August 2022

Global warming is global issue in modern times.Global warming and climate change have affected the entire world. It is essential to take preventive measures to reduce heat wave and temperature of Earth for protection of human life animal life and plant life. Islamic ecological instructions can play an important role to eradicate current global warming. Deforestation is main cause of global warming.Trees are natural sources of oxygen and cooling in the atmosphere .Trees play a key role in maintaining natural ecological balance of planet Earth.The plants and trees provide humane life with fresh, clean and cool oxygen to breath. Heat wave in recent times must be controlled by planting as many trees as possible.30 percent area of Pakistan was covered with forest and green trees in 1947 but gradually it has shrunk to 5 percent in these days. Deforestation has increased imbalance, disorder, global warming, climate change, air pollution and other many more ecological and biological issues. Every person is hardly motivated to plant new trees more and more in Islamic teachings. This article explores Islamic teachings, preventive measures for global warming prevention.
PENGARUH KECANGGIHAN TEKNOLOGI INFORMASI, KEMAMPUAN TEKNIK PESONAL DAN PENGALAMAN KERJA TERHADAP EFEKTIVITAS PENGGUNAAN SISTEM INFORMASI AKUNTANSI (STUDI KASUS PADA SICEPAT EKSPRES INDONESIA)
Authors: Bukhori Muslim Ahmad , Yani Novi Akmal , Permatasari Maulina Dyah 
Published: August 2022

Penelitian ini bertujuan untuk mengetahui pengaruh kecanggihan teknologi informasi, kemampuan teknik personal dan pengalaman kerja terhadap efektivitas sistem informasi akuntansi. Lokasi penelitian ini dilakukan di SiCepat Ekspres Indonesia. Sampel dalam penelitian ini terdiri atas 107 karyawan pengguna sistem informasi akuntansi yang dipilih dengan teknik simple random sampling dari populasi seluruh karyawan Departemen Finance SiCepat Ekspres Indonesia. Data diperoleh melalui survey dengan menggunakan kuesioner dan dianalisis dengan metode analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa secara parsial, kecanggihan teknologi informasi berpengaruh positif dan signifikan terhadap efektivitas sistem informasi akuntansi, kemampuan teknik personal berpengaruh positif dan signifikan terhadap efektivitas sistem informasi akuntansi, pengalaman kerja tidak berpengaruh terhadap efektivitas sistem informasi akuntansi. Secara simultan kecanggihan teknologi informasi, kemampuan teknik personal, dan pengalaman kerja berpengaruh terhadap efektivitas penggunaan sistem informasi akuntansi.
Benefits of SEL in a Foreign Language and Exam Preparation Class
Authors: Hashimoto Natasha 
Published: August 2022

This paper describes the classroom context and challenges that led me to include social-emotional learning (SEL) in my teaching in the English as a foreign language learning context in a Japanese university. I discuss specific strategies and activities I utilized in an online course with a group of English language majors and share some, largely positive, outcomes of the approach. The SEL practices are known to include strategies that allow learners to increase their social awareness and self-awareness, participate in responsible decision making, self-manage, and manage their relationships with others. However, unlike in typically implemented school-wide SEL curricula and programs (CASEL, n.d.; Elias et al., 1997), the approach I utilized meant introducing only a handful of activities and strategies in the classroom. Nevertheless, the findings show that most students found the strategies beneficial.
本稿は、私が日本の大学で英語を教える際に、社会性と情動の学習方法（SEL）を取り入れるに至った背景と課題について述べる。また、英語専攻の大学生を対象としたオンラインコースで私が活用した具体的な戦略とアクティビティについて述べ、そのアプローチによるいくつかの、主に肯定的な結果について共有する。SELの実践には、学習者が社会性や自己認識力を高め、責任ある意思決定に参加し、自己管理し、他者との関係を管理するための戦略が含まれている。基本的に、SELプログラムは全校規模で実施されるもの（CASEL, n.d.; Elias et al., 1997）であるが、今回はそのうち一部の活動や戦略のみを教室で導入した。それにもかかわらずほとんどの学生が当該ストラテジーを有益だと感じていることがわかった。
The Evolution of Lyα Emitter Line Widths from z = 5.7 to z = 6.6
Authors: Songaila A. , Barger A. J. , Cowie L. L. , Hu E. M. , Taylor A. J. 
Published: August 2022

Abstract
Recent evidence suggests that high-redshift Lyα emitting galaxies (LAEs) with

log
L
(
Ly
α
)
>
43.5

erg

s

−
1

, referred to as ultraluminous LAEs (ULLAEs), may show less evolution than lower-luminosity LAEs in the redshift range z = 5.7–6.6. Here we explore the redshift evolution of the velocity widths of the Lyα emission lines in LAEs over this redshift interval. We use new wide-field, narrowband observations from Subaru/Hyper Suprime-Cam to provide a sample of 24 z = 6.6 and 12 z = 5.7 LAEs with

log
L
(
Ly
α
)
>
43

erg

s

−
1

, all of which have follow-up spectroscopy from Keck/DEIMOS. Combining with archival lower-luminosity data, we find a significant narrowing of the Lyα lines in LAEs at

log
L
(
Ly
α
)
<
43.25

erg

s

−
1

—somewhat lower than the usual ULLAE definition—at z = 6.6 relative to those at z = 5.7, but we do not see this in higher-luminosity LAEs. As we move to higher redshifts, the increasing neutrality of the intergalactic medium should increase the scattering of the Lyα lines, making them narrower. The absence of this effect in the higher-luminosity LAEs suggests they may lie in more highly ionized regions, self-shielding from the scattering effects of the intergalactic medium.
Analysis of the Content of Escherichia Coli in Public Bathing Pools Before and After Using Visitors
Authors: Nasrullah Nasrullah , Syahrizal Syahrizal , Kartini Kartini 
Published: August 2022

BACKGROUND: Escherichia coli is a bacterium that commonly causes diarrhea almost all over the world. E. coli can grow well on almost all media commonly used to isolate enteric bacteria. E. coli bacteria are organisms that generally live in the human digestive tract. E. coli bacteria are commonly found in polluted swimming pools, causing its users.

AIM: The aim of this study was to determine the difference in E. coli content in swimming pool water in public baths.

METHODS: The method in this study uses a descriptive survey method. The research location is at the Poltekkes Laboratory of the Ministry of Health, Aceh, October to December 2021. Sampling is at one of the natural attractions used for public baths in the Aceh Besar area. The subject of this research is swimming pool water in public baths for children as much as 5 points of 5 L/point, and adults 5 points of 5 L/point; all water taken is 50 L.

RESULTS: The results showed that before visitors bathed in the swimming pool, the number of E. coli colonies had a minimal average (12.1) with a deviation of 4.977. The distribution of the number of E. coli colonies after 9 h was used by visitors, which had an average E. coli colony of 190.9 with a deviation of 30.490 MPN, who received that the intervention also showed that the number of E. coli colonies after 9 h was very high, with an average of 159.4 and a deviation of 32.898 MPN.

CONCLUSION: There is a difference in the average content of E. coli before and after using public baths by visitors. The number of users of public baths affects the number of microorganisms in the water, such as E. coli and Enterococci.
Physical Rehabilitation Therapy for Long COVID-19 Patient with Respiratory Sequelae: A Systematic Review
Authors: Prabawa I Made Yoga , Silakarma Dedi , Prabawa I Putu Yuda , Manuaba Ida Bagus Amertha Putra 
Published: August 2022

Background. Coronavirus disease 19 (COVID-19) infection has been a global pandemic since late 2019. Clinical manifestation ranges from mild to severe. Even though most COVID-19 patients recover fully from the disease, approximately 5–10% experience prolonged symptoms for several months following the acute COVID-19 phase, defined as long COVID-19 syndrome. Rehabilitation therapy is needed for them to overcome their symptoms and improve their functional capacity. This systematic review aims to discuss rehabilitation therapy for a patient with long COVID-19 syndrome. Method. A systematic review using PubMed and Google Scholar was conducted based on PRISMA guidelines. Inclusion criteria were study about rehabilitation therapy for long COVID-19 patients. Exclusion criteria were letters to the editor, editorial or commentary reports, and studies not available in full-text and not in English or Bahasa. Result. Nine studies are included in this systematic review consisting of two consensus statements or recommendations, one cohort retrospective study, two case studies or case reports, one review and three experimental studies. The recommended rehabilitation program pathway using a three-tier model depends on the severity of the disease. Several rehabilitation exercises for long COVID patients include cardiorespiratory rehabilitation, breathing exercise, therapeutic exercise, and even traditional Chinese fitness models such as Liuzijue exercise. Conclusion. Rehabilitation therapy exercise helps to improve the patient's breathing effort, improving dyspnea and muscle strength. Keywords: long COVID-19 syndrome, physical rehabilitation, post-COVID-19 infection, rehabilitation therapy
Le colbertisme d’hier et d’aujourd’hui
Authors: Méreaux Jean-Paul , Seiffert Marc-Daniel 
Published: August 2022

Du 17 e siècle au 21 e siècle, le colbertisme a connu des hauts et des bas. C’est lui qui, depuis la Libération, a inspiré le capitalisme à la française. Or, à partir des années 1970, s’est imposé un capitalisme de plus en plus libéral. Conséquence de cette nouvelle politique, notre pays a connu la désindustrialisation la plus forte de l’Europe continentale. Ceux qui s’inquiétaient de la perte de notre souveraineté économique n’ont pas été écoutés jusqu’à ce que pandémie et guerre en Ukraine confirment ces craintes. La crise sanitaire a montré les limites de l’approche libérale et mis en évidence la dépendance de la France dans de nombreux secteurs. Dans le cadre des débats actuels sur une nouvelle politique économique, les principes du colbertisme peuvent-ils être une source d’inspiration ?
Abnormal Longitudinal Strain Reduction of Basal Left Ventricular Segments in Patients Recovered of COVID-19
Authors: Cotella Juan I. , Hasbani Javier , Hasbani Eduardo , Prado Aldo 
Published: August 2022

Background:
The Severe acute respiratory syndrome coronavirus 2, is the pathogen that causes COVID-19. Cardiovascular (CV) involvement during this infection, has been related to adverse outcomes. Interestingly, some patients may remain symptomatic beyond the first 14 days of disease diagnosis. Although a particular reduction on left ventricular (LV) global longitudinal strain (GLS) in basal segments has been recently described in patients hospitalized with diagnosis of COVID-19, the correlation of these findings with the persistence of symptoms has not been determined.

Objectives:
The objective of this study is to describe echocardiographic findings in patients recovered from COVID-19 and to determine its association with persistent dyspnea.

Methods:
Seventy-six patients were analyzed. Forty-six were asymptomatic (group N°1) and 30 referred persistent dyspnea at the time of examination (group N°2), and a cohort of 25 healthy individuals was included as a control group. Total LV GLS, average basal LV GLS, and average mid-apical LV GLS were assessed. Basal-mid-apical index (BMAI) was calculated. A difference in BMAI bigger than 15% between both groups was stablished as cutoff point.

Results:
Nonsignificative differences on standard echocardiographic measurements were found between the analyzed groups. When compared to the control group, there was nonsignificative reduction on basal LV GLS values in patients with persistent dyspnea. However, BMAI values were bigger than 15% in 70% of patients from group N°2 but in none of the patients from the control group (= 0.0002).

Conclusions:
This new index allowed to identify an abnormal relation in LV GLS values between basal and medium-apical segments among patients recovered from COVID-19 and persistent dyspnea.
Effect of Coronavirus Disease-2019 Infection on Left Atrial Functions
Authors: Ergül Elif , Özyildiz Ali Gökhan , Emlek Nadir , Özyildiz Afag , Duman Hakan , Çetin Mustafa 
Published: August 2022

Objective:
Left atrial (LA) dysfunction is a crucial risk factor for cardiovascular events, and various pathologies may affect LA function. Coronavirus disease-2019 (COVID-19) is an ongoing global pandemic causing morbidity and mortality. In the present study, we aimed to evaluate LA functions in patients who recovered from COVID-19.

Methods:
Sixty consecutive patients recovered from COVID-19 and 60 healthy individuals as a control group were included in the study. Blood samples and echocardiography measurements were obtained from each subject. The two groups were compared in terms of demographic and echocardiographic characteristics.

Results:
In the COVİD-19 group, LA maximum volume (LAVmax) (P = 0.040), LA pre-A volume (LAVpre-A) (P = 0.014), and LA active emptying fraction (P = 0.027) were higher, while LA passive emptying fraction (P = 0.035) was lower. In addition, left ventricular ejection fraction (P = 0.006) and isovolumetric relaxation time (P = 0.008) were decreased in this group. Although LA volume index was higher in the COVID-19 group, it does not reach statistical significance.

Conclusion:
LA functions may be impaired in patients recovered from COVID-19 infection.
An Adolescent with Ileum Herniation Through Foramen of Winslow
Authors: Huang Y , Qin L , Wu L , Huang Q 
Published: August 2022

Background:Herniation through foramen of Winslow is a relatively rare group of hernias characterized by protrusion of the abdominal contents into the lesser sac. To our knowledge, this is the youngest and the only reported case related to adolescents in the last five years.Case Presentation:A 15-year-old male patient presented to our emergency department after experiencing 4 hours of acute dull upper abdominal pain. We diagnosed the patient with herniation through foramen of Winslow by computed tomography (CT) and other complementary diagnostic methods. After a 3-trocar laparoscopic procedure, the hernia was successfully repositioned and no bowel resection was required. The patient was discharged on the fourth postoperative day without complications. He was no recurrence six months after operation.Conclusions:Through the review of the literature, it is clear that herniation through foramen of Winslow (HFW) is a more challenging condition to diagnose preoperatively, which can be achieved with the help of complementary diagnostics especially CT. As a category of diseases with a very low postoperative recurrence rate, clinical experience tells us that only three-trocar laparoscopic surgery can successfully return HFW.