bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-dimensional mismatch and barriers for promoting PrEP among men who have sex with men in China: a cross sectional survey from the Demand-side
Authors: Guan Yuan , Qi Tangkai , Huang Wei , Zhang Renfang , Chen Jun , Liu Li , Shen Yinzhong , Zhu Han , Tang Qi , Lu Hongzhou 
Published: June 2022

Abstract
Men who have sex with men (MSM) is a key population for preventing HIV in China, yet Pre-Exposure Prophylaxis (PrEP) is not widely accepted in this population. An online questionnaire survey was conducted from December 2018 to January 2019. Among 1915 MSM from 34 geographical regions of China, 512 (26.7%) versus 1617 (84.4%) had an objective or subjective need of PrEP, respectively. One hundred and six (5.5%) reported affordability and only 23 (1.2%) had ever taken it. A wide disconnect exists among the objective need, willingness, affordability and uptake of PrEP. Age, living alone and occupation were associated with the objective needs. Education, occupation, sexual behavior were associated with the willingness. Age, income, sexual behavior were associated with actual usage. Cost was the most prevalent barrier, accounting for 78.22% of individuals who needed and wished for PrEP but finally failed to receive it. The findings might facilitate optimizing future allocation of resources to better promote PrEP in Chinese MSM.
Secondary organic aerosol formation from mixed volatile organic compounds: Effect of RO2 chemistry and precursor concentration
Authors: He Hong , Chen Tianzeng , Zhang Peng , Chu Biwu , Ma Qingxin , Ge Yanli , Liu Jun 
Published: June 2022

Abstract
Secondary organic aerosol (SOA) plays a significant role in contributing to atmospheric fine particles, as well as in global air quality and climate. However, the current understanding of the atmospheric formation of SOA and its simulation is still highly uncertain due to the complexity of its precursor VOCs. In our study, SOA formation in different mixed VOC scenarios was investigated using a 30 m3 indoor smog chamber. By comparing SOA formation in individual VOC scenarios, it was found that SOA formation from anthropogenic VOCs (AVOCs) can be positively (+ 83.9%) affected by coexisting AVOCs, while inhibited (-51.4%) by the presence of isoprene, via the OH scavenging effect. The cross-reactions of peroxyl radical (RO2) generated from different AVOCs were proved to be the main contributor (up to 39.0%) to SOA formation, highlighting the importance of RO2 + RʹO2 reactions in mixed VOC scenarios. Meanwhile, the formation of gas-phase organic intermediates of different volatility categories from the RO2 reactions was also affected by the precursor concentration, and a higher SOA yield was found at lower precursor concentrations due to the larger contribution of intermediates with lower volatility. Our study provides new insights into SOA formation by considering the interactions between intermediate products from mixed VOCs.
Pd on cyclotriphosphazen-hexa imine decorated boehmite as an efficient catalyst for hydrogenation of nitro arenes under mild reaction condition
Authors: Sadjadi Samahe , Abedian-Dehaghani Neda , Heravi Majid 
Published: June 2022

Abstract
Cyclotriphosphazen-hexa imine ligand was prepared through successive reactions of phosphonitrilchloride trimer with 4-hydroxybenzaldehyde and (3-aminopropyl) triethoxy silane. The as-prepared ligand was then covalently grafted on boehmite to furnish an efficient support for immobilization of Pd nanoparticles and synthesis of a novel heterogeneous catalyst for hydrogenation of nitro arenes. The catalytic tests revealed that the catalyst had excellent catalytic activity for hydrogenation of various nitro arenes with different steric and electronic features under mild reaction condition in aqueous media. Noteworthy, the catalyst was highly selective and in the substrates with ketone or aldehyde functionalities, reduction of nitro group was only observed. The catalyst was also recyclable and only slight loss of activity was detected after each recycling run. Hot filtration test also approved true heterogeneous nature of catalysis.
WITHDRAWN: The Effects of Mask Usage During the COVID-19 Pandemic on Temporomandibular Joint
Authors: Akturk Ezgi Sunal , Aydin Ilke , Seker Elif Dilara 
Published: June 2022

Abstract
Objectives: To evaluate possible temporomandibular joint disorder (TMD) symptoms that may occur due to mask use in dentists during the COVID-19 pandemic period and reveal the potentially effective factors.Materials and Methods: An online questionnaire, consisting of three parts, was sent to dentists and clinical dental students. The first part included questions for sociodemographic information. In the second part, questions were asked to evaluate stress levels, TMD symptoms, and treatment of TMD if any for before (T0) and during the pandemic (T1). In the last part, professional mask choice, mask-related parafunctional movements, and breathing pattern while wearing a mask were evaluated.Results: TMD symptoms and stress level were found significantly higher at T1. An increase in mouth breathing and mask-related parafunctional movements was reported during the use of N95 masks compared to daily life in dentists whose professional mask selection was N95 respirator. The change in TMJ pain and muscle pain at rest between the T0 and T1 was higher in those whose professional mask choice was N95 respirators than those who chose to wear one surgical mask. Conclusion: The increase in mouth breathing and mask-related parafunctional movements during the use of N95 respirators may cause an increase in TMD.Clinical Relevance: During the use of N95 respirator masks, an increase in mouth breathing and mask-related parafunctional movements can be observed. It should be considered that this situation may cause an increase in the TMD symptoms.
Synthesis of porous titanium heterostructure MOF for the photocatalytic degradation of amoxicillin from wastewater
Authors: Dhivya Egambaram , Magadevan Deviga , Mundari Noor Danish Ahrar , Mishra Trilochan , Aman Noor 
Published: June 2022

Abstract
Antibiotic usage for medical treatment and its production has drastically increased its concentration level in the aquatic environment. Amoxicillin is a well-known bacterial antibiotic used widely in the world. The heterostructured MOF HMF-2 is synthesized by integrating MIL-125 and NH2-MIL-125 via the refluxing method. The physicochemical properties of all synthesized MOFs were studied using XRD, FE-SEM, FT-IR, N2 physisorption, UV-Vis (DRS), XPS, and PL. XRD indicates synthesized MOFs having intense peaks exhibiting crystallinity and framework nature. BET surface area of MIL-125, NH2-MIL-125, and HMF-2 are found to be 986, 1267, and 1102 m²/g respectively indicating their microporous nature. NH2-MIL-125 integrated with MIL-125 decreases the bandgap of HMF-2 thereby extending its visible light absorption. The visible light degradation of Amoxicillin in an aqueous solution is studied with MIL-125, NH2-MIL-125, and HMF-2 for a period of 1 to 7 days. HMF-2 is found to show better activity in comparison with the individual MOFs because of more efficient charge separation. This study intends to give new directions for the sustainable degradation of antibiotics from wastewater.
Central nervous system effects of TAK-653, an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole receptor (AMPAR) positive allosteric modulator in healthy volunteers
Authors: Dijkstra Francis , O'Donnell Patricio , Klaassen Erica , Buhl Derek , Asgharnejad Mahnaz , Rosen Laura , Zuiker Rob , Gerven Joop van , Jacobs Gabriel 
Published: June 2022

Abstract
TAK-653 is a novel AMPA receptor positive allosteric modulator in clinical development for the treatment of major depressive disorder (MDD). This study aimed to measure the functional pharmacodynamic central nervous system (CNS) effects of TAK-653. A randomised, double-blind, placebo-controlled, three-way crossover (placebo, TAK-653 0.5 mg and 6 mg) study with 24 healthy volunteers was performed. NeuroCart tests consisting of body sway (BS), saccadic peak velocity (SPV), smooth pursuit eye movements (SP), adaptive tracking (AT), Bowdle and Bond and Lader Visual Analogue Scales (B-VAS and BL-VAS) and Stroop test were performed pre-dose and 3.5 and 4 hours post-dose. Data were analysed using a mixed model analysis of covariance with baseline as covariate. It was found that TAK-653 did not affect BS and subjective drug effects as measured by B-VAS and BL-VAS at either dose level. TAK-653 0.5 mg increased SPV (degrees/second) (19.49 [5.98, 32.99], P = 0.02) and affected Stroop difference in reaction time between correct congruent and correct incongruent answers and number of correct responses in incongruent trials (22.0 [4.0, 40.0], P = 0.05 and − 0.3 [− 0.5, − 0.1], P = 0.02, respectively). TAK-653 6 mg improved AT (%) (1.68 [0.51, 2.84], P = 0.02) and increased SPV (degrees/second) (15.40 [1.91, 28.90], P = 0.06) and SP (%) (2.32 [0.37, 4.27], P = 0.05). Based on these findings it can be concluded that TAK-653 demonstrated a psychostimulant-like pharmacodynamic profile on the NeuroCart consistent with previously reported increase of cortical excitability following Transcranial Magnetic Stimulation (TMS) of the human motor cortex.
Anti-EGF nanobodies enhance the antitumoral effect of osimertinib and overcome resistance in non-small cell lung cancer (NSCLC) cellular models
Authors: Guardiola Salvador , Sánchez-Navarro Macarena , Rosell Rafael , Giralt Ernest , Codony-Servat Jordi 
Published: June 2022

Abstract
Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is effective against the EGFR T790M mutation in patients with advanced non-small-cell lung cancer (NSCLC). However, acquired resistance appears invariably due to several mechanisms. The strategy of using EGF-targeted nanobodies (Nbs) to block the initial step of the EGFR pathway constitutes a new research area. Nbs offer several advantages compared to traditional mAbs, such as their reduced size, increased stability and tissue penetration, which provide key advantages for targeting soluble tumoral growth factors. In this study we investigated the efficacy of anti-EGF Nbs to reduce Osimertinib resistance. Two anti-EGF Nbs, generated in our laboratory, were shown to inhibit cell viability and colony formation in PC9 and PC9-derived osimertinib-resistant cell lines. The combination of these Nbs with osimertinib improved the antitumoral efficacy of this EGFR-TKI in cell viability and colony formation experiments. In a mechanistic study of the EGFR pathway, the combination treatment dampened the activation of downstream proteins such as Akt and Erk1/2 MAP kinases. In addition, it increased cellular apoptosis and decreased the expression of Hes1, a cancer stem cell marker involved in metastasis and osimertinib resistance. We conclude that the addition of anti-EGF nanobodies enhances the antitumoral properties of osimertinib, thus representing a potentially effective strategy for NSCLC patients.
Insights into the health status of the general population living near an electroplating industry zone: metal elevation and renal impairment
Authors: Xu Peiwei , Lai Shiming , Wu Lizhi , Chen Weizhong , Chen Yuan , Xu Dandan , Xiang Jie , Cheng Ping , Chen Zhijian , Wang Xiaofeng , Tang Jun , Lou Xiaoming 
Published: June 2022

Abstract
To evaluate the body burdens of metals and metalloids associated with renal dysfunction in residents living near electroplating industries, a cross-sectional study was conducted in 2016 in Zhejiang Province, China. We recruited 236 subjects and performed physical examinations; determined the blood and urinary levels of arsenic (As), cadmium (Cd), chromium (Cr), manganese (Mn), nickel (Ni), lead (Pb), antimony (Sb), and selenium (Se) by an inductively coupled plasma mass spectrometer (ICP-MS); and measured three renal impairment biomarkers, namely Nacetyl-β-D-glucosaminidase (NAG), retinol binding protein (RBP), and β2-microglobulin (BMG). The proportion of abnormal nasal symptoms in the exposure group (10.1%) was much higher than in the control group (0; p < 0.05). Both the blood and urinary levels of As, Cd, and Se in the exposure group were significantly higher than the levels in the control group (p < 0.05). The blood levels of Mn and Pb, as well as the urinary levels of Cr and Ni, in the exposure group were significantly higher compared to the control group (p < 0.05). The exposure group demonstrated higher levels of NAG, RBP, and BMG compared to the control group (0.51 vs. 0.14 mg/g creatinine, 12.79 vs. 9.26 IU/ g creatinine, 1.39 vs. 0.78 mg/g creatinine, respectively; p < 0.05). Urinary BMG was positively correlated with urinary Cd levels (r = 0.223, p < 0.05), while urinary RBP was correlated with blood Cd levels (r = 0.151, p < 0.05) and urinary Cd, Cr, Ni, and Se levels (r = 0.220, 0.303, 0.162, and 0.306, respectively; p < 0.05). In conclusion, our study indicated that residents living in the vicinity of electroplating industries were bearing high body burdens of certain metals and metalloids associated with nonnegligible renal dysfunction.
Physiological and statistical aspects of immunoregulatory and antioxidant properties of tryptophan
Authors: Pajouhanfar Hadi , Ghazaghi Mahmoud , Mehri Mehran 
Published: June 2022

Abstract
Tryptophan (Trp) is the third or fourth limiting amino acid for the most poultry species fed on corn-soybean meal-diets, playing an important role in the profile of the blood biochemical variables, humoral immunity, and antioxidant capacity. A dose-response assay was carried out to investigate the effects of graded levels of dietary Trp on blood variables, immunity and meat quality in quail chicks during the last two weeks of growing period. A total of 420, 21-day-old quail chicks were randomly distributed across the seven experimental groups (i.e., 2.12, 2.25, 2.38, 2.51, 2.64, 2.77, and 2.90 g Trp /kg of diet) with 4 pen replicates of 15 birds each. Blood variables including uric acid (UA), albumin (ALB), and triglycerides (TG) responded inversely to increasing dietary Trp (P < 0.001). Blood concentration of aspartate aminotransferase (AST), relative weight of bursa of Fabricius (BF), immunoglobulin G (IgG), water holding capacity (WHC), and antigen production against the sheep red blood cells (SRBC) increased with increases in dietary Trp (P < 0.001). In contrast, the concentration of malondialdehyde (MDA) and drip loss in meat samples decreased with increasing dietary Trp (P < 0.001). The best models for determination of optimal dietary Trp were selected based on a statistical merit called model accuracy index (δ). The optimal amounts of dietary Trp for optimizing ALP, UA, total protein (TP), TG, SRBC, IgG, BF, drip loss, WHC, and MDA were estimated at 2.347, 2.371, 2,372, 2.485, 2,691, 2.738, 2.306, 2.359, 2.247, and 2.500 g/kg of diet, respectively. Principal component analysis showed that UA, TG, IgG, and drip loss had the higher association with dietary Trp compared to the rest responses. Taking into account of high δ and eigenvalues for fitted bird responses, the more reliable estimation of optimal Trp for optimization of studied responses in quail chicks would be 2.738 g Trp/kg of diet, which was significantly higher than that recommended for the quail performance.
A call for culture-centred care: Is continuity of care possible if culture remains an appendix in the mainstream health care system for Aboriginal families [across the first 1000 days] in South Australia?
Authors: Sivertsen Nina , Deverix Janiene , Gregoric Carolyn , Grant Julian 
Published: June 2022

Abstract
Background:Aboriginal women and their infants experience significant disadvantage in health outcomes compared to their non-Aboriginal counterparts. Access to timely, effective, and appropriate maternal and child health care can contribute to reducing these existing health disparities. This research sought to explore factors that contribute to continuity of care for Aboriginal women and their infants living in metropolitan South Australia. This paper reports on the perspectives of health care workers in mainstream health services from the antenatal period to the end of an infants’ second birthday. It explores health workers’ perspectives of what contributes to positive care experiences and satisfaction with care provided to Aboriginal women and their infants in mainstream health.Methods: Eight focus groups were held with 52 health professionals. Participants included Aboriginal Cultural Consultants (n=7), Aboriginal Maternal Infant Care Workers (n=3), Midwives (n=3) and Child and Family Nurses(n=39). Data was inductively coded and thematically analysed.Results: Three key themes emerged: the system takes priority, culture is not central in approaches to care, and ‘we’ve got to be allowed to do it in a different way’. Conclusions: This research highlights a lack of continuity of care for Aboriginal families accessing mainstream health services from the antenatal period through to an infants’ first 1000 days of life. This research has implications for communities, and it calls for strategies to enhance continuity, and healthcare services to provide appropriate and culturally safe care. Findings will inform and guide future changes to improve continuity of care for Aboriginal families and infants in the first 1000 days.
Assessment of Lung Ventilation and Perfusion of Premature Infants with Bronchopulmonary Dysplasia at 1.5 Tesla Using Phase-Resolved Functional Lung (PREFUL) Magnetic Resonance Imaging (MRI) in the NICU
Authors: Dyke Jonathan P , Voskrebenzev Andreas , Blatt Lauren K , Vogel-Claussen Jens , Grimm Robert , Worgall Stefan , Perlman Jeffrey M , Kovanlikaya Arzu 
Published: June 2022

Abstract
Background: The most common complication of preterm birth is bronchopulmonary dysplasia (BPD), widely referred to as the chronic lung disease of prematurity. All current definitions rely on characterizing the disease based on respiratory support level, and do not provide full understanding of the underlying cardiopulmonary pathophysiology.Objective: To evaluate a rapid functional lung imaging technique in premature infants in the Neonatal Intensive Care Unit (NICU) to quantitate pulmonary ventilation and perfusion using 1.5 Tesla Magnetic Resonance Imaging (MRI).Methods: We conducted a prospective MRI study of 12 premature infants in the NICU using the phase resolved lung (PREFUL) MRI technique to calculate pulmonary ventilation and perfusion parameters in preterm infants with and without bronchopulmonary dysplasia (BPD) Grade 0/1 (n=6) and Grade 2/3 (n=6).Results: The exclusive ventilation defect percentage (VDP%) showed a significant increase in premature infants with Grade 2/3 BPD vs. Grade 0/1 BPD [15.0% vs. 7.0%, p=0.008]. The total VDP% also showed a significant increase between groups [16.0% vs. 8.0%, p=0.013]. No significant perfusion defect percentages (QDP%) were found between groups. Conclusion: PREFUL lung MRI is feasible for assessment of ventilation and perfusion defect percentages in preterm infants in the NICU and shows regional variation in localized lung function in this vulnerable population.
Can aivo Intervention with Artificial Intelligence Alleviate Medical Trauma in Children?
Authors: Tanaka Kyoko , Hayakawa Maoko , Noda Chihiro , Nakamura Akio , Akiyama Chieko 
Published: June 2022

Abstract
Background: Procedures and actions such as injections and immobilization cause distress to children. In the pediatric field, there is a need for interventions and support to alleviate the pain and distress caused by such medical procedures. In recent years, the introduction of robots as a means of distraction has begun to be attempted. Methods: In this study, we conducted a non-randomized controlled trial to examine the effect of intervention using ‘aibo’, a dog-like robot which has artificial intelligence (AI), to promote distraction in children after vaccination. Children between the ages of 3 and 12 years old eligible for the Japanese encephalitis vaccine, and their caregivers were assigned to intervention group or control group. Then, children evaluated their pain and children’s behavior were observed by observer. The mean values of Faces pain rating scale scores and observer pain scale scores were compared between groups using an unpaired t-test.Results: Fifty-seven children (32 in the intervention group) participated in the study. Results of a t-test with the control group showed that the intervention group using aibo had significantly less pain following the post-vaccination intervention than the control group using stuffed dog (Face Scale, t(55) = 2.582, p = .0125; Behavioral Observation Scale, t(55) = 2.772, p = .00759). The results support the hypothesis that the aibo intervention group will be less distressed and able to calm down more quickly after vaccination than the control group. Conclusion: Interactive communicative play intervention by an artificially intelligent aibo before and after painful and frightening medical procedures may alleviate fear and anxiety and prevent medical trauma in children.
Shaking Table Experiment of Human Comfort under Blasting Vibration and Engineering Application
Authors: Zhang Jikui , Jiang Nan , Zhou Chuanbo , Zhao Ke , zhu Bin 
Published: June 2022

Abstract
To reasonably assess the impact of blasting disturbance on personnel in the adjacent area and to protect the safety and physical and mental health of personnel, it is the key to construct a human comfort evaluation system under the impact of blasting vibration. In view of the uncertainty of human subjective feelings in the existing evaluation system of human comfort under the influence of blasting vibration, the human vibration response experiment is carried out by simulating blasting vibration through a shaking table, and the quantitative relationship between blasting vibration parameters, ECG indicators, and human subjective feelings is analyzed by combining with human ECG indicators to construct the evaluation system of human comfort under the influence of blasting vibration. At the same time, the evaluation system is applied to the actual project with Wuhan Metro Line 5 as the engineering background by combining numerical calculation methods. The results show that: the vertical direction is the main vibration direction affecting human comfort, and the impact of vibration on the human body is related to the main vibration sensation parts of the human body, and the degree of impact gradually increases when the main vibration sensation parts moves up from the feet to the head; There is a quantitative relationship between the decreased ratio of human ECG index RMSSD and blasting vibration parameters as well as human subjective feelings, when the decrease ratio of human RMSSD is greater than 0.28, the extent to which the human feels the degree of annoyance cannot be ignored, and the vibration velocity and frequency (0.7cm/s, 80Hz) in the vertical direction of the ground surface at this time can be used as the control threshold of blasting works in the adjacent densely populated areas; When the distance from the blasting center is less than 62.57m, the physical and mental health of tourists in the Yellow Crane Tower scenic spot will be greatly affected, it is recommended that the maximum explosive charge in the single delay of the subway tunnel blasting excavation does not exceed 0.32kg.