bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theranostics and Nanoparticular Approaches for the Treatment of Oral Squamous Cell Carcinoma
Authors: Bhattacharya Sankha 
Published: May 2022

Abstract:Oral squamous cell carcinoma (OSCC), one of the most common types of oral cancer, is a significant cause of morbidity and mortality worldwide. OSCC is typically treated with a multidisciplinary approach that includes surgery, chemotherapy, and radiation after a definitive oral cancer diagnosis. Conventional chemotherapy drugs, on the other hand, maybe ineffective and have a variety of side effects. Many techniques for treating and diagnosing various types of oral cancer have been proven and approved, while others are currently being researched in clinical trials. This mini review aimed to explain the current preclinical status of nano-based techniques for diagnosing and treating OSCC successfully. This mini compilation also highlights new theranostics approaches for treating squamous cell carcinoma (OSCC). Cancer biomarker detection has also been improved thanks to nanotechnology, which has made it faster and more sensitive. Various nanoparticles have been used as innovation drivers to overcome these constraints and enhance in-situ drug delivery.
Pyrrolopyridine and Isoindole as Potential Anticonvulsant Agents: Design,
Synthesis, and Pharmacological Evaluation
Authors: Davood Asghar , Taghizad Sepideh , Behbahaninia Khadijeh , Jahromy Mahsa Hadipour 
Published: May 2022

Background and Objective:
Phthalimide, as the rigid form of ameltolide, exhibits a phenytoin-like profile of drug-receptor interaction and is active in the MES model and inactive in the PTZ model as an anti-epileptic agent. In this research, based on the isosteric replacement, we reported the design, preparation, and antiepileptic activity of 13 new analogs of pyrrolopyridine and isoindole.

Methods:
The designed compounds were prepared by condensing 3, 4-pyridine dicarboxylic anhy-dride, or 4-fluorophthalic anhydride with different aryl amines. MES and PTZ-induced seizure models were utilized to evaluate the antiepileptic effect of the prepared ligands.

Results:
It was found that the prepared ligands have significantly affected both tonic and clonic sei-zures. In tonic seizures, the prepared compounds decreased mortality to a significant extent, and in clonic seizures, they significantly showed better frequency and latency. Compounds 9, 12, and 13 were the most potent ligands than phenytoin.

Conclusion:
It is concluded that the best distance between two aryl parts is two bonds, and the sub-stitution of the nitro group at the meta position of the phenyl ring is better than the para position. Our research group has investigated this concept for designing newer compounds with better anti-convulsant activity.
The Racial Differences in Impact and Knowledge of COVID-19
Among Patients with Psychiatric Illnesses
Authors: Jin Jeff Wang , Nishikawa Millie , Ho Tiffany , Manohar Roja , Sanches Marsal , Cavalcanti Stefanie , Wu Hanjing 
Published: May 2022

Introduction:
COVID-19 pandemic has been associated with increased rates of depression,
anxiety, and suicidal ideation. Individuals with mental illnesses are disproportionately
affected by additional complex health issues. This study aims to examine the knowledge and
impact of COVID-19 among patients with mental disorders at the Harris County Psychiatric
Center (HCPC).

Methods:
A retrospective review of surveys was conducted for patients with mental illness at
HCPC. Participants were surveyed on demographics, COVID-19 knowledge, and COVID-19
healthcare impact. The data were analyzed with SPSS 20 for Windows at a 0.05 significance
level.

Results:
A total of 46 patients were included in the study. We found that the patient population
with mental disorders has different methods of obtaining information regarding COVID-19 and
practices varying safety measures. To be precise, more women (52.2%) than men (21.7%)
learned about COVID-19 through family and friends (p=0.032). More Hispanic (21.4%) compared
to non-Hispanic (0%) patients learned about COVID-19 through resources from the
World Health Organization (WHO) (p=0.032). Fewer African American (AA) patients avoided
contact with people who were sick (39% vs. 81%) Caucasian (p=0.01) and (100%)
Asian/Native American/Pacific Islander [ANAPI] patients (p=0.04). We found more non-
Hispanic (50.0%) vs. Hispanic (7.1%) patients reported that their personal time (time outside of
work) was unchanged by COVID-19 (p=0.007). More Hispanic (57.1%) vs. non-Hispanic
(17.9%) patients reported increased time with family members (p=0.009). Compared to Hispanic
patients, more non-Hispanic patients reported unchanged difficulty scheduling appointments
(46.4% vs. 7.1%) (p=0.015), obtaining prescription (71.4% vs. 35.7%) (p=0.045), and
finding housing placement (53.6% vs. 21.4%) (p=0.047). Furthermore, more Caucasian compared
to AA patients reported more changes in how they feel (35.7% vs. 76.2%) (p=0.033),
anxiety (52.6% vs. 0%) (p=0.002), stress (47.4% vs. 7.7%) (p=0.024), and sadness (30% vs.
0%) (p=0.031). Finally, more ANAPI (67%) compared to AA patients (0%) reported increased
anxiety (p=0.025).

Conclusion:
Our findings suggest that African American patients report less knowledge of
COVID-19 prevention and less impact on their mental health by the pandemic compared to
other racial groups. Our findings suggest that African American patients may have limited
knowledge of COVID-19 prevention compared to other races, Caucasian and Asian/Native
American/Pacific Islander patients may have increased mood changes, and Hispanic patients
may be experiencing more healthcare inequality amidst the pandemic. However, further investigation
of the impending ramifications of the pandemic is warranted.
Photovoltaic Performance of Si and SiGe Surfaces Sonochemically Activated
in Dichloromethane
Authors: Korotchenkov Oleg , Shmid Volodymyr , Podolian Artem , Nadtochiy Andriy , Semen'ko Mykhailo 
Published: May 2022

Aims:
To activate Si and SiGe surfaces by employing the sonochemical treatment at different operating frequencies in dichloromethane to improve the surface photovoltage signal.

Background:
To produce integrated electronic devices, one needs to achieve low surface and interface trap densities. In this respect, placing a passivating thin layer on Si and Ge surfaces, which saturates the electronic levels of traps and therefore affects the carrier recombination velocities at the surface, is of great interest.

Objective:
To demonstrate that the effectiveness of the treatment of Si and SiGe surfaces depends on the ultrasonic frequency used.

Methods:
Photovoltaic transients, electron microscopy, EDX spectroscopy.

Result:
The surface photovoltage (SPV) decay curves can be divided into rapid (τ_1) and slow (τ_2) components. The sonication effect on the SPV is different for the treatment done at about 25 and 400 kHz. The SPV signal in Si gradually increases with increasing lower-frequency sonication time, whereas the SPV enhancement on SiGe is somewhat smaller. Increasing the sonication time increases the amplitude of the τ_2 component in Si. In SiGe, the lower-frequency sonication quenches the τ_2 component yielding a nearly single-exponential decay form. This trend is even more pronounced at the higher-frequency sonication.

Conclusion:
The sonochemical treatments greatly intensify the formation of CxHy–Si and CxHy–Ge bonds on Si and Si1-xGex surfaces, resulting in increased SPV signals and prolonged SPV decay times. These results demonstrate that sonochemical treatment is a more effective technique to obtain stable highly passivated Si and Si1-xGex surfaces in comparison with wet chemical treatments in hydrocarbon solutions.
A KNN Algorithm Based Predictive Model for Heart Disease Progression
Authors: Jaffrin Lijetha C. , Srikanth G. Umarani 
Published: May 2022

Background:
Disease diagnosis was a vital responsibility in healthcare. Machine learning classification methods would considerably improve the healthcare industry by providing a quick diagnosis of disease. Thus, time could be saved for doctors. Nearly 17.9 million people expire due to heart disease every year.

Objectives:
World Health Organization predicted that rate of death might increase by 24.5 million in 2030. Since heart illness was the major cause of death in comparison with other diseases today, it was the most challenging disease to diagnose.

Methods:
One of the reasons for death due to heart disease was due to the fact that risks were not identified in the earlier stage. Earlier diagnosis of disease was very much important. Machine Learning algorithms were used for predicting the prognosis of disease.

Results:
Here K-NN algorithm was used to predict the presence of heart disease in an individual. Thus, patients were classified as either positive or negative for heart disease and this model enhanced medical care and reduced the cost. This gave us significant knowledge that helps us to predict the patients with heart disease.

Conclusion:
The Python sci-kit library was used to implement this in Anaconda Navigator's Spyder Integrated Development Environment. Experiments revealed that technique worked well and was more accurate than before.
Heliodorus’ <i>Aethiopica</i>: A New Patristic Context
Authors: Krauss Katherine 
Published: May 2022

This article argues that reading Heliodorus’ Aethiopica alongside post-Nicene Patristic texts sheds new light on its place within the multifaceted religious world of Late Antiquity. Through an analysis of three discrete test cases, this article brings to light the complexities of the Aethiopica’s incorporation of ideas which are prominent in contemporary Christian thought. In so doing, it presents new evidence for the fourth-century context in which Heliodorus produced his work.
Microinjertación de naranja Valencia y lima Tahití
Authors: Suárez Isidro E. , Álvarez Correa Cristian , Lopez Diaz Claudia 
Published: May 2022

Para determinar la viabilidad de microinjertación en plantas de naranja Valencia y lima Tahití como un método de propagación masiva de plantas, diferentes pasos del proceso de microinjertación fueron evaluados. Las semillas de mandarina Cleopatra fueron establecidas in vitro en medio semisólido MS (Murashige y Skoog) con, o sin, GA3, para evaluar su efecto en el porcentaje y el tiempo de germinación, las plantas de naranja Valencia y lima Tahití fueron tratadas con 1 mg l-1 BAP o podadas manualmente para evaluar el efecto sobre la producción de brotes vegetativos, y el efecto de tres posiciones del ápice meristemático en la superficie del patrón decapitado, en el centro, en un lado y en un corte inclinado, sobre el porcentaje de éxito fue evaluado. Las repeticiones de todos los experimentos fueron distribuidas con un diseño completamente al azar, los datos de brotes vegetativos fueron analizados con ANAVA y los promedios separados con la prueba de Tukey. Los resultados evidenciaron que el GA3 no afectó el porcentaje y tiempo de germinación y la poda incrementó estadísticamente el número de brotes vegetativos. Los porcentajes de éxito de microinjertos de naranja Valencia (28%) y lima Tahití (14%) son consistentes con los resultados de otros estudios para recuperar plantas libres de enfermedades; sin embargo, para propagación masiva, se recomienda en futuros estudios considerar la evaluación de condiciones in vitro como aumento en la concentración de sacarosa, adaptación in vitro de los ápices meristemáticos y adición de auxina, entre otros.
From Guardianism to Postmodernism: Historiography and the Interpretation of Canadian Political Culture
Authors: Pearce Colin D. 
Published: May 2022

This article seeks to go some way toward shedding light on a certain dimension of Canadian intellectual history, specifically that dimension wherein the changing theoretical approaches to the phenomenon of Canadian political culture is the core subject matter. Canadian political culture will be defined here as that collation of ideas, principles, thoughts and opinions which foster the establishment and continuation of a set of political structures and institutions which are liberal democratic at their foundations. With this as a guiding definition the article examines the “paradigm shifts” in the study of English Canadian political culture that have taken place from the days of “The Makers of Canada,” through the ascendancy of the “Fragment Thesis,” to the more contemporary postmodernism of the “Liberal Order Framework.” The foundational assumption of the article is that debate and discussion about the Canadian experience in such fields as political philosophy, intellectual history, party ideology, constitutional structure, legislative procedure, executive power, judicial authority and local governance will tend to be shaped by the historiographical paradigm which has been most successful in making itself the accepted “orthodoxy” in the academic and intellectual circles of the period.
Expanding Social Justice: Exploring Connections Between Immigration and Indigeneity
Authors: Thomas Brian 
Published: May 2022

Most discussions of group--‐differentiated disadvantage seek to explain its covert and overt nature through the experiences of dominant groups and their relations to subordinate groups. This is a vertical approach to social injustice. Instead of taking this approach, I take a horizontal approach that seeks to determine whether there are logics that produce disadvantage that are invisible to the vertical understandings of socially constructed group--‐ differentiated disadvantage. To this end, I critically consider the relationships between disadvantaged groups by reflecting on the experiences of Black Canadians and Canadian Aboriginals. Their experiences reveal the underbelly of Canadian multiculturalism and of discourses of membership and belonging. I explore the ways in which these groups have potentially complex and conflicting modes of injustice that elicit potentially conflicting and complex prescriptions. Recognizing this has the potential to facilitate a finer--‐grained sensitivity to the description and potential amelioration of group--‐differentiated disadvantage and to problematize discourses of membership and belonging in their instantiation in current Canadian practices, norms, and governing arrangements.
Clinical features and upper airway symptoms in association with severity and outcome in patients with COVID-19
Authors: Hadi Furaq Hussain , Kadhim Iman Jabbar , Deli Falah Abdulhasan 
Published: May 2022

Objectives: To assess the relationship between the early occurrence of upper respiratory tract symptoms and the severity of SARS-COV-2 infection.Methods: A cohort observational study had been conducted on a total of 140 patients [60 mild, 40 moderate, 40 severe], diagnosed with SARS-CoV-2 between 4th of August and 31 of October 2020. Patients diagnosed by PCR or chest CT scan or both of them. A full history was taken from the patients and data including the age of the patient, gender, occupation, residence, height, weight, history of previous comorbidities {cardiovascular, Diabetes mellitus, Hypertension, chronic respiratory disease, chronic renal disease, malignancy, and other diseases}. Smoking and alcoholic history were also taken, clinical features {loss of smell/taste, sore throat, rhinorrhea, fever, cough, shortness of breath, headache, fatigue, myalgia, arthralgia, diarrhea, and vomiting} and temperature, SPO2, investigations, the need for respiratory support {O2, non-invasive ventilation, invasive ventilation} and any complications developed during illness.
Results: Mean age of the patients was 51(range:17-82) Males were dominant; (57.1%) with male to female ratio of 1.33 to one, out of the 140 COVID-19 patients, 63 (45%) had upper respiratory symptoms. Regarding biomarkers of severity only S.LDH was significantly lower in cases who did have compared to those who did not have upper respiratory symptoms, 1.3 ± 1.4 vs. 1.7 ± 1.3, respectively. The mean SPO2% was significantly higher in patients with upper respiratory symptoms compared to those without. Percent of Pulmonary damage was significantly lower in patients with upper Respiratory symptom compared to those without. Mortalities were significantly lower in patients with upper respiratory symptoms compared to those without; among the 113 patients with upper respiratory symptom compared only 7(6.2%) died compared to 7 out of 27 (25.9%) patients with no upper respiratory symptom.Conclusion: Early occurrence of upper respiratory tract symptoms predicts less severe form of the disease.
Teoría del lugar central: caso centro agrícola cantonal de Pastaza - Ecuador
Authors: Nuñez Alexis Alexander Núñez , Ruales Edgar Fabián Ruales , Almeida Luis Anderson Argothy , Guamán Jaime Fernando Andrade 
Published: May 2022

El presente trabajo busca determinar la relación entre la ubicación de los puestos con el nivel de ventas de los comerciantes del Centro Agrícola Cantonal de Pastaza basándose en la Teoría del Lugar Central. Para ello, primero se realizó una actualización de la base de datos de los comerciantes del Centro Agrícola, los puestos desocupados y vendedores que no asisten al mercado, mediante la técnica de observación de campo. Posteriormente, se elaboró una encuesta a 174 comerciantes para conocer la situación actual de los puestos y con estos datos de fuente primaria se aplicó un modelo econométrico ANOVA para evaluar la significancia estadística de la relación a determinar. Los resultados de la observación de campo demuestran que el 31% de los puestos que posee el mercado se encuentran desocupados. Además, se observó que las variables “bueno” y “malo” son significativas al 1%, 5% y 10% y el modelo es estadísticamente significativo dado su valor p de Fisher de 3,35E-07. Se concluye que existe relación entre la ubicación de los puestos y el nivel de ventas el cual se contempla dentro de la Teoría del Lugar Central.
Japón en el 2022. La pandemia, las olimpiadas y la sombra de Shinzo Abe
Authors: Román Zavala Alfredo 
Published: May 2022

Como quedó asentado en el reporte del Anuario Asia Pacífico de 2020, Yoshihide Suga fue elegido como primer ministro de Japón, sucediendo a Shinzo Abe. Suga llegó para garantizar la estabilidad y la continuidad en el gobierno y la política. En septiembre de 2020, Suga sucedió a Abe con cuatro desafíos importantes: mantener bajo control el brote de covid- 19, encarrilar la economía y llevar a cabo los Juegos Olímpicos y Paralímpicos de 2020. Suga heredó, como cuarto punto, la intensificación del conflicto entre Estados Unidos y China. En pocas palabras, Suga comenzó su administración con toda una serie de problemas que se fueron agravando paulatinamente y que, al final, terminaron avasallándolo a él y forzando reacciones de distinta índole en el plano de la política y de la sociedad. Esos cuatro desafíos se relatan con minuciosidad en el contexto japonés de 2022.
Assessing the diversification risk of a single equity market: evidence from the largest European stock indexes
Authors: Nuhiu Artor , Aliu Florin , Peci Bedri 
Published: May 2022

Abstract
Diversification of financial securities is considered a substantial element of portfolio risk. In this context, the construction of an optimal portfolio is an ongoing concern for portfolio managers. This study measures the risk–reward tradeoffs linked to the stock indexes of Germany, Spain, Italy, France, and England. First, the stock indexes are analyzed as individual portfolios and later compared to the hypothetical common equity index. The results show diversification benefits gained from a hypothetical common European stock market. Individual stock prices and trade volumes are collected weekly from January 1, 2008 to December 31, 2018. The results indicate that, on average, the most well-diversified equity indexes are IBEX35, FTSE MIB, and FTSE100. In contrast, DAX, MDAX, and CAC40 on average tend to be less diversified. The diversification risk for DAX, MDAX, and CAC40 decreases from joining a common hypothetical stock market, while for FTSE100, FTSE MIB, and IBEX it increases.
Current Perspectives on Development of Industry 4.0 in Logistics of Machinery and Equipment Industry in Slovakia
Authors: Richnák Patrik 
Published: May 2022

Abstract
The aim of the paper was to evaluate the current situation of Industry 4.0 in logistics in the machinery and equipment industry in Slovakia. The intention of the paper was to fill a research gap in the form of identification and analysis of the studied issue in the selected industry in Slovakia. The identification and analysis of the subject issue were conducted in 57 enterprises in the machinery and equipment industry in Slovakia. The results of the investigated issues were interpreted through descriptive and inferential statistics. The research instrument was a questionnaire, which involved a construction of several types of questions. The results of the testing showed that enterprises with different numbers of employees perceive, implement and use Industry 4.0 technologies in logistics. Also, based on the statistical hypothesis testing, it was confirmed that big data and the Internet of Things are the most used of the Industry 4.0 technologies in the selected logistics processes. The connection between Industry 4.0 and Logistics 4.0 will be an increasingly dominant theme as the Fourth Industrial Revolution represents a change that almost every enterprise in the world is going through or will go through.
Analisis Peraturan Penggunaan QRIS Sebagai Kanal Pembayaran Pada Praktik UMKM Dalam Rangka Mendorong Perkembangan Ekonomi Digital
Authors: Tobing Gabriella Junita , Abubakar Lastuti , Handayani Tri 
Published: May 2022

Abstract

The purpose of this study is to analyze the Regulation of the Use of QRIS as an innovation of Bank Indonesia in the payment system and to know its Policy Implementation in business development or MSME activities as an effort to accelerate the development of the digital economy. The research method used is normative juridical research method as well as legal history, with descriptive analytical specifications. Data collection from this study is assisted by the method of document study and interview which is then analyzed qualitatively. Based on the results of this study, it was obtained that the implementation of QRIS based on existing regulations through PADG has not been optimal and comprehensive, then further regulations are needed to regulate the problem of digital economic innovation that can reach QRIS users to even the smallest sectors, such as PBI. Thus, MSMEs can help play a role in creating inclusive finance so as to encourage the development of the digital economy in Indonesia.

Abstrak

Tujuan penelitian ini adalah untuk menganalisis Peraturan dari Penggunaan QRIS sebagai inovasi Bank Indonesia dalam sistem pembayaran serta mengetahui Implementasi Kebijakannya dalam pengembangan bisnis atau kegiatan UMKM sebagai upaya percepatan perkembangan ekonomi digital. Metode penelitian yang digunakan adalah metode penelitian yuridis normatif serta sejarah hukum, dengan spesifikasi deskriptif analitis. Pengumpulan data dari penelitian ini dibantu dengan metode studi dokumen serta wawancara yang kemudian dianalisis secara kualitatif. Berdasarkan hasil penelitian ini, diperoleh bahwa Pelaksanaan QRIS berdasarkan peraturan yang ada melalui PADG belum optimal dan komprehensif, maka dibutuhkan peraturan lebih lanjut untuk mengatur permasalahan inovasi ekonomi digital yang dapat menjangkau pengguna QRIS sampai ke sektor yang terkecil sekalipun, layaknya PBI. Dengan demikian UMKM dapat membantu berperan mendorong perkembangan ekonomi digital di Indonesia.