bluuebunny/crossref_metadata_2025_split huggingface dataset:
Filtering, editing, and cropping yield maps in a R environment with the package cleanRfield
Authors: Matcham Emma G. , Matias Filipe , Luck Brian D. , Conley Shawn P. 
Published: April 2022

AbstractCleaning yield monitor observations to remove erroneous points can improve the accuracy of yield estimates used for farm record keeping or on‐farm research data collection, but current practices are time‐intensive and cumbersome. cleanRfield is an open‐source R package to improve the efficiency of processing spatial agricultural data such as yield maps. Compared with current standard yield monitor data cleaning solutions, cleanRfield can read and interpret a broader range of input data formats. Other key features of cleanRfield include automatic field boundary delineation and batch processing of data from multiple fields. In this Scientific Note, we overview functions within the cleanRfield package and introduce an integrative pipeline to evaluate and visualize yield monitor data. The package is being distributed under the GNU General Public License 2, and a more detailed tutorial including downloading instructions is available at https://github.com/filipematias23/cleanRfield.
A NaHCO3 Promoted Three‐component Cyclization: Easy Access to Benzodisulfide Heterocycles
Authors: Zhou Yong‐Jun , Yang Kai , Fang Yong‐Gan , Luo Shi‐He , Chen Qi , Yu Shi‐Wei , Wang Zhao‐Yang 
Published: April 2022

AbstractA facile route for the synthesis of benzodisulfide heterocyclic compounds via a NaHCO3‐promoted three‐component reaction between 2‐halophenylacetic acids, elemental sulfur (S8) and amines under metal‐free conditions has been demonstrated. This transformation from available starting materials shows good functional group tolerance, and the target compounds can be derivatized for further application.
A population‐based study of homelessness, antisocial behaviour and violence victimisation among young adults in Victoria, Australia
Authors: Heerde Jessica A. , Bailey Jennifer A. , Patton George C. , Toumbourou John W. 
Published: April 2022

AbstractHomeless young adults are at increased risk for contact with the police and are overrepresented in the justice system. This study explored associations between homelessness, antisocial behaviour and violence victimisation using longitudinal panel data gathered through young adulthood. Data were drawn from a state representative population‐based sample of young adults from Victoria, Australia participating in the International Youth Development Study (IYDS; n = 2884, 54% female). Participants were surveyed at age 21 years, with follow‐up at ages 23 and 25 years. We examined changes in the prevalence of homelessness and tested hypothesised directional relationships between young adult homelessness, antisocial behaviour and violence victimisation using longitudinal cross‐lagged panel models. Multiple‐group modelling was used to test whether these relationships were moderated by gender. The prevalence of young adult homelessness was highest at age 21 (6.5%), declining at ages 23 (3.9%) and 25 years (2.5%). Results showed that young adult homelessness, antisocial behaviour and victimisation were related cross‐sectionally, but not longitudinally. Gender did not significantly moderate these associations. Findings suggest that the state of homelessness is associated with temporary vulnerability to potentially harmful and problematic situations involving antisocial behaviour and victimisation. These situations are likely to heighten risk for contact with the police and direct physical and psychological harm.
The Tris(pentafluorophenyl)methylium Cation: Isolation and Reactivity
Authors: Hoffmann Kurt F. , Battke David , Golz Paul , Rupf Susanne M. , Malischewski Moritz , Riedel Sebastian 
Published: April 2022

AbstractHerein, we present two different routes for the synthesis of the perfluorinated trityl cation, which allowed the handling of the free, uncoordinated species in organic solvents for the first time. The usage of the weakly coordinating anion [Al(OTeF5)4]− and its derivatives allows the characterization of this species by NMR spectroscopy and most importantly by single‐crystal X‐ray diffraction. The high hydride ion affinity of the cation is shown by hydrogen abstraction from isobutane. Furthermore, cyclic voltammetry reveals its oxidative potential which is supported by the reaction with tris(4‐bromophenyl)amine, giving rise to the formation of the ammoniumyl radical cation, also known as “magic blue”.
AS1411 conjugated magnetic‐based poly N‐isopropyl acrylamide nanoparticles for delivery of erlotinib to prostate cancer cells
Authors: Foroughi‐Nia Behrouz , Aghanejad Ayuob , Kadkhoda Jamileh , Barar Jaleh , Nosrati Hamed , Davaran Soudabeh 
Published: April 2022

AbstractThe present study expanded the magnetic pH‐dependent, and nucleolin receptor‐targeted nano‐drug delivery system consists of synthesized superparamagnetic iron oxide nanoparticles (SPIONs) and poly N‐isopropyl acrylamide (PNIPAM) with aptamer AS1411 to deliver the erlotinib (ERL) to prostate cancer (PC) cells. Their properties were characterized using different techniques. The encapsulation efficiency (EE) and drug loading (DL) were found to be about 34% and 85%, respectively. The characterization studies disclosed that formulated SPION‐PNIPAM/ERL@AS1411 nanoparticles (NPs) were spherical with an average particle size of 97.8 nm, polydispersity index (PDI) of 0.03, and the zeta potential of −2 mV. The flow cytometry and cell viability assay results disclosed that SPION‐PNIPAM/ERL@AS1411 NPs operated cancer cell death via the pH‐sensitive release of ERL. The conjugation of the AS1411 modified the cellular uptake of ERL as proved by cellular sensing fluorescence. Therefore, the present study revealed that the SPION‐PNIPAM/ERL@AS1411 NPs improved the treatment effect of ERL in PC via the nucleolin‐targeted drug release.
Synthesis of curcumin‐loaded shellac nanoparticles via co‐precipitation in a rotating packed bed for food engineering
Authors: Zou Yuanzuo , Wang Fen , Li Angran , Wang Jie‐Xin , Wang Dan , Chen Jian‐Feng 
Published: April 2022

AbstractPractical application of versatile nanomaterials to food engineering is desirable. In this study, highly encapsulated curcumin‐loaded shellac (Cur@Lac) nanoparticles are efficiently prepared via a rotating packed bed (RPB). In this modified co‐precipitation process, the morphology of Cur@Lac nanoparticles is systematically investigated under experimental parameters involving the high‐gravity level, the volume of antisolvent and the concentration of shellac. By virtue of the highly structured polymeric ester matrices of shellac and adequate supersaturation brought from RPB on a microscale, the obtained Cur@Lac nanoparticles with uniform size exhibit high encapsulation efficiency of over 96%. After 2 months of storage at room temperature, the aqueous Cur@Lac nanodispersions exhibit long‐term stability with no agglomeration or sedimentation, and the final retention rate of curcumin was over 85%. Colored drinks of fruit syrup (pH = 4.0), fruit soda (pH = 6.0), and soda water (pH = 8.3) are prepared by using the Cur@Lac as the colorant, which possessed orange‐yellow color. The nanocomposites of alkali‐sensitive indicators based on cellulose paper and gelatin film demonstrated in the work show promising application value for sensing of alkaline solution and gas of perishable food.
Novel pyrazolo[3,4‐b]pyridine derivatives: Synthesis, structure–activity relationship studies, and regulation of the AMPK/70S6K pathway
Authors: Guo Yating , Jiang Xiaoding , Chang Qi , Xiao Zhihong , Chen Zhuo , Jiang Dejian , Hu Gaoyun , Li Qianbin 
Published: April 2022

AbstractA series of novel pyrazolo[3,4‐b]pyridine derivatives were designed, synthesized, and biologically evaluated for anti‐lung cancer activity. Structure–activity relationship and AutoGPA models were constructed based on the in vitro antiproliferative potency of the compounds against a human lung adenocarcinoma cell line (A549). Compound 9d exhibits improved potency for A549 cell growth inhibition (3.06 ± 0.05 μM) compared with A‐769662 (45.29 ± 2.14 μM). Compound 9d can elevate the phosphorylation levels of adenosine monophosphate‐activated protein kinase (AMPK) and its substrate acetyl‐CoA carboxylase and reduce the level of phosphorylated ribosomal S6 kinase (p‐70S6K) at 1 μM, which is comparable to the activity of A‐769662 at 20 μM. 9d induced G2/M cell cycle arrest, which was rescued when co‐incubated with “Compound C,” a potent AMPK inhibitor. Taken together, compound 9d showed potential anti‐lung cancer activity via inducing cell cycle arrest by regulation of the AMPK/70S6K pathway in A549 cells, which could provide a new lead for the discovery of anti‐lung cancer agents.
Reduced Graphene Oxide (rGO)‐Supported and Pyrolytic Carbon (PC)‐Coated γ‐Fe2O3/PC‐rGO Composite Anode Material with Enhanced Li Storage Performance
Authors: Hao Chenran , Gao Tiange , Wang Jiulin , Yuan Anbao , Xu Jiaqiang 
Published: April 2022

AbstractAs a high‐capacity anode material for lithium ion batteries, γ‐Fe2O3 is a promising alternative to conventional graphite among multifarious transition metal oxides owing to its high theoretical specific capacity (1007 mAh g−1), abundant reserves, good safety and low cost. However, improving the electrical conductivity and overcoming the morphological damage caused by the severe volume expansion during cycling are still the tricky problems to be solved. Herein, a three‐dimensional heterostructure composite (γ‐Fe2O3/PC‐rGO60) was prepared by a facile solvothermal reaction followed by heat treatment in inert atmosphere. This composite material exhibits a reversible charge specific capacity of 1035 mAh g−1 at the current density of 0.1 A g−1. After 100 cycles at 0.2 A g−1, the capacity is increased from 966.2 to 1091.1 mAh g−1. Even cycled for 200 cycles at 1 A g−1, the capacity is only decreased from 751.4 to 670.6 mAh g−1, giving capacity retention of 89.3%. The rGO network supported flexible composite architecture is beneficial for accommodating the volume expansion of the γ‐Fe2O3 active material during the lithiation/delithiation process. Besides, the conductive rGO network and the in‐situ formed pyrolytic carbon (PC) can provide a smooth electron transmission path and a favorable lithium ion transport channel.
Atomic‐ and Molecular‐Level Modulation of Dispersed Active Sites for Electrocatalytic CO2Reduction
Authors: Juthathan Methasit , Chantarojsiri Teera , Tuntulani Thawatchai , Leeladee Pannee 
Published: April 2022

AbstractGlobal climate changes have been impacted by the excessive CO2emission, which exacerbates the environmental problems. Electrocatalytic CO2reduction (CO2RR) offers the solution for utilising CO2as feedstocks for value‐added products while potentially mitigating the negative effects. Owing to the extreme stability of CO2, selectivity and efficiency are crucial factors in the development of CO2RR electrocatalysts. Recently, single‐atom catalysts have emerged as potential electrocatalysts for CO2reduction. They generally comprise of atomically‐ and molecularly dispersed active sites over conductive supports, which enable atomic‐level and molecular‐level modulations. In this minireview, catalyst preparations, principle of modulations, and reaction mechanisms are summarised together with related recent advances. The atomic‐level modulations are first discussed, followed by the molecular‐level modulations. Finally, the current challenges and future opportunities are provided as guidance for further developments regarding the discussed topics.
Rich 1T‐MoS2 Nanoflowers Decorated on Reduced Graphene Oxide Nanosheet for Ultra‐Quick Zn2+ Storage
Authors: Long Fei , Shi Junjie , Zhang Qixiang , Liu Zunyu , Hou Yixin , Mao Ke , Liu Nishuang , Li Luying , Long Fei , Gao Yihua 
Published: April 2022

AbstractAqueous zinc‐ion batteries (AZIBs) with low cost and high safety are promising energy storage equipment for large‐scale grids. However, the further development of AZIBs is obstructed by finite usability of cathode materials. Recently, layered materials represented by MoS2 have attracted attentions because they can provide facile two‐dimensional (2D) channels for the diffusion of Zn2+, but low capacity and poor rate capability limit their applications. Herein, two classical layered materials are combined to form a stable heterostructure (MoS2‐rGO) by in‐situ growing metallic 1T‐MoS2 nanoflowers on reduced graphene oxide (rGO) to provide more 2D channels for electrons transfer and Zn2+ diffusion. The MoS2‐rGO heterostructure exhibits high specific capacity (303.10 mAh g−1 at 0.20 A g−1) and ultrahigh rate capability (102.70 mAh g−1 at 20.00 A g−1, i. e., capacity retention of 33.88 % for a 100‐fold increase in current density) in aqueous electrolyte. Furthermore, the quasi‐solid‐state aqueous zinc‐ion battery based on MoS2‐rGO heterostructure also shows high electrochemical performance at bending states and extreme temperature. This work provides an inspiration for construction of AZIBs with high‐performance layered cathode.
Implications of the genomic revolution for education research and policy
Authors: Morris Tim T. , von Hinke Stephanie , Pike Lindsey , Ingram Neil R. , Davey Smith George , Munafò Marcus R. , Davies Neil M. 
Published: April 2022

AbstractResearch at the intersection of social science and genomics, ‘sociogenomics’, is transforming our understanding of the interplay between genomics, individual outcomes and society. It has interesting and maybe unexpected implications for education research and policy. Here we review the growing sociogenomics literature and discuss its implications for educational researchers and policymakers. We cover key concepts and methods in genomic research into educational outcomes, how genomic data can be used to investigate social or environmental effects, the methodological strengths and limitations of genomic data relative to other observational social data, the role of intergenerational transmission and potential policy implications. The increasing availability of genomic data in studies can produce a wealth of new evidence for education research. This may provide opportunities for disentangling the environmental and genomic factors that influence educational outcomes and identifying potential mechanisms for intervention.
A hybrid boronate affinity probe for the selective detection of cis‐diol containing compounds in tea beverages
Authors: Liu Yunchun , Hua Liyun , Zhu Wanru , Liu Chen , You Hongrui , Chen Hongqi 
Published: April 2022

AbstractUiO‐66‐NH2 nanocomposite was post‐modified with 4‐mercaptophenylboronic acid (MPBA) by the method of in situ hybridization reaction. The hybrid boronate affinity material UiO‐NH2@P (TEPIC‐co‐MPBA) was characterized by scanning electron microscopy, X‐ray diffraction and Fourier‐transform infrared spectroscopy. The material was applied as fluorescent probe for the detection of cis‐diol containing compounds based on the boronate affinity mechanism, and exhibited high specific selectively. The proposed method exhibited good linearity for the detection of catechol in the range of 0.50 to 8.00 μg ml−1. The detection limit was 0.13 μg ml−1. The tactic was successfully applied to analyze the total polyphenols in tea beverages for catechol, and relative recovery was in 98.86–106.00%. Therefore, this work provided a promising strategy for the recognition of cis‐diol containing compounds.
Maturity levels of sustainable corporate entrepreneurship: The role of collaboration between a firm's corporate venture and corporate sustainability departments
Authors: Schönwälder Jeremy , Weber Anja 
Published: April 2022

AbstractTo shed light on how incumbent firms implement sustainable corporate entrepreneurship (SCE) processes, this study investigates how organizations connect sustainability and venture departments. Based on qualitative interviews with 14 experts from 12 multinational corporations headquartered in Germany, we identified five maturity levels of SCE with increasing cross‐functional collaboration: Non‐Existent, Occasional, Expert, Collaboration, and Strategic Collaboration. Using secondary interview data from seven multinational companies headquartered outside Germany, we find initial support for these collaboration types in an international context. Results indicate that a company's general approach to innovation is associated with its SCE maturity level: companies with dedicated entrepreneurship units are more likely to have a higher level of SCE focus. Furthermore, the likelihood of working on radical innovations for sustainability seems to increase as soon as venture experts collaborate with sustainability managers, which, in turn, increases the chances of initiating sustainability transitions.
The deep fascia and its role in chronic pain and pathological conditions: A review
Authors: Kondrup Flemming , Gaudreault Nathaly , Venne Gabriel 
Published: April 2022

AbstractThe deep fascia is a three‐dimensional continuum of connective tissue surrounding the bones, muscles, nerves and blood vessels throughout our body. Its importance in chronically debilitating conditions has recently been brought to light. This work investigates changes in these tissues in pathological settings. A state‐of‐the‐art review was conducted in PubMed and Google Scholar following a two‐stage process. A first search was performed to identify main types of deep fasciae. A second search was performed to identify studies considering a deep fascia, common pathologies of this deep fascia and the associated alterations in tissue anatomy. We find that five main deep fasciae pathologies are chronic low back pain, chronic neck pain, Dupuytren's disease, plantar fasciitis and iliotibial band syndrome. The corresponding fasciae are respectively the thoracolumbar fascia, the cervical fascia, the palmar fascia, the plantar fascia and the iliotibial tract. Pathological fascia is characterized by increased tissue stiffness along with alterations in myofibroblast activity and the extra‐cellular matrix, both in terms of collagen and Matrix Metalloproteases (MMP) levels. Innervation changes such as increased density and sensitization of nociceptive nerve fibers are observed. Additionally, markers of inflammation such as pro‐inflammatory cytokines and immune cells are documented. Pain originating from the deep fascia likely results from a combination of increased nerve density, sensitization and chronic nociceptive stimulation, whether physical or chemical. The pathological fascia is characterized by changes in innervation, immunology and tissue contracture. Further investigation is required to best benefit both research opportunities and patient care.
Anosmia following middle nasal concha resection: An anatomic and developmental review with clinical correlation
Authors: Bolger William E. , Lockett Elizabeth , Bolger Ian M. 
Published: April 2022

AbstractLosing the sense of smell can be associated with a significant decrease in quality of life. Fortunately, this occurs infrequently with modern paranasal sinus surgery that has stressed minimally invasive, tissue‐sparing principles. However, over time, more extensive surgical applications have emerged that incorporate increased tissue removal. Post‐operative period sequelae can occur, including anosmia. Understanding the potential implications of expanded tissue removal, such as middle nasal concha (turbinate) resection, is clinically important and is facilitated by an understanding of anatomy. Our understanding of anatomic nuances is enhanced through an appreciation of embryonic and fetal development. We herein review the developmental anatomy of the middle nasal concha of the ethmoid sinus and olfactory nerve area as it relates to middle nasal concha removal during endoscopic sinus surgery. We present images from our analysis of 12 embryonic and fetal specimens that highlight the important relationship between the middle nasal concha and olfactory nerves. We also review the clinical issues surrounding turbinate preservation versus resection and present a clinical correlation to underscore the uncommon but significant complication of anosmia following sinus surgery with middle nasal concha resection. We highlight knowledge gaps, discuss case selection and review surgical technique modifications for middle nasal concha surgery to reduce the chance of this complication in the future.
Impact of cirrhosis on long‐term survival outcomes of patients with intrahepatic cholangiocarcinoma
Authors: Wang Jian , Qiu Yiwen , Yang Yi , Shen Shu , Zhi Ming , Zhang Bo , Wang Wentao 
Published: April 2022

AbstractBackgroundThe correlation between cirrhosis and the long‐term oncological outcome in intrahepatic cholangiocarcinoma (ICC) is debatable, and this study aimed to explore the impact of cirrhosis on the long‐term prognosis of patients with ICC.MethodsA total of 398 ICC patients were identified in the Surveillance, Epidemiology, and End Results (SEER) database from 2000 to 2018. The diagnosis of cirrhosis was based on the Ishak fibrosis score provided by the SEER database. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) analysis were performed to minimize the potential confounders. Overall survival (OS) and cancer‐specific survival (CSS) were observed, and the Cox regression model was used to select potential factors that affect the prognosis of the patients with ICC.ResultsOf the included patients, there were 142 patients and 256 patients in the cirrhotic and noncirrhotic groups, respectively. Additionally, 299 of 398 patients (75.1%) died following a median follow‐up of 19 months (interquartile range [IQR], 7, 43). The OS and CSS indicated advantage trend in the noncirrhotic group than the cirrhotic group in either the original cohort (OS: 17 vs 12 months, p = 0.023; CSS: 26 vs 15 months, p = 0.004) or the PSM (OS: 17 vs 12 months, p = 0.52; CSS: 22 vs 14 months, p = 0.15) or IPTW (OS: 20 vs 13 months, p = 0.163; CSS: 22 vs 15 months, p = 0.059) cohorts. Subgroup analyses displayed that the prognosis of patients who experienced surgery for ICC in the noncirrhotic group was better than that of the cirrhotic group with regard to OS and CSS.ConclusionsCollectively, it seems that the noncirrhotic patients have similar relative OS but better CSS compared with that of the cirrhotic patients.
Window Approach for Simultaneous Root Fragment Removal and Implant Placement: Two Case Reports
Authors: Wu Yi‐Chu , Pellegrini Gretel G. , Garfinkel Leonard , Kang Philip 
Published: April 2022

IntroductionRoot fracture during extraction is not uncommon due to the presence of multiple and thin roots, which are often divergent and curved. The retained root fragments (RF) are usually radiographic incidental findings and often asymptomatic without associated pathology. However, careful and conservative surgical strategies for the removal of RF must be incorporated to allow for simultaneous implant placement and to avoid potential complications such as compromised osseointegration or retrograde peri‐implantitis. Conventional RF removal techniques may lead to a significant amount of bone removal, involving more trauma and a prolonged healing period.Case PresentationIn these two case reports, the Window Approach for Simultaneous Root Fragment Removal and Implant Placement (WASRIP) technique was used to extract RF in a minimally invasive fashion to preserve both the coronal and apical bone, which are critical components in providing mechanical stability for simultaneously placed implants. All implants presented in both cases showed adequate primary stability and successfully achieved osseointegration at a 3‐month follow‐up period.ConclusionThrough the buccal window, sufficient access was provided to remove RF atraumatically with maximal retention of surrounding bone that led to predictable implant placement.