bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel weight optimized dynamic conformal arcs with TrueBeam™ Linac for very small tumors (≤1 cc) with single isocenter of multiple brain metastases (2≤, ≥4) in stereotactic radiosurgery: A comparison with volumetric modulated arc therapy
Authors: Sağlam Yücel 
Published: July 2022

ABSTRACT

Introduction:
We evaluated whether improved increase delivery efficiency of weight optimized dynamic conformal arc (WO-DCA) therapy in comparison to volumetric modulated arc therapy (VMAT) with single isocenter for SRS treatment of very small volume and multiple brain metastases (BMs).

Materials and Methods:
20 patients having a less than 1 cc volume and 2≤, ≥4 of multiple BMs, redesigned for 20 Gy in 1 fraction using WO-DCA and VMAT techniques with double full coplanar and three partial noncoplanar arcs. Plan qualities were compared using tumor coverage, conformity index (CI), gradient index (GI), V4Gy, V10Gy, and V12Gy volumes of brain, monitor units (MUs), and percent of quality assurance pass rate (QA%).

Results:
Both techniques satisfied clinical requirements in coverage and CI. VMAT had a significantly higher MU and mean GI than WO-DCA (for MUs; 2330 vs. 1991; P < 0.001, and for GI; 4.72 vs. 3.39; P < 0.001). WO-DCA was found significantly lower V4Gy (171.11 vs. 232.80 cm3, P < 0.001), V10Gy (25.82 vs. 29.71 cm3, P < 0.05), and V12Gy (14.35 vs. 17.28 cm3, P < 0.05) volumes than VMAT. WO-DCA was associated with markedly increase QA pass rates for all plans (97.65% vs. 92.64%, P < 0.001).

Conclusions:
WO-DCA may be the first choice compared to the VMAT in reducing the dose in the brain and minimizing small-field dosimetric errors for very small SRS treatment of brain metastases in the range of ≤ 1 cc and 2≤, ≥4.
Usefulness of palliative radiotherapy in reducing the frequency of red blood cell transfusion in patients with malignant tumor bleeding
Authors: Katano Atsuto , Yamashita Hideomi 
Published: July 2022

ABSTRACT

Objective:
We aimed to evaluate the usefulness of palliative radiotherapy in reducing the frequency of red blood cell (RBC) transfusions in patients with malignant tumor bleeding as a quantitative value to evaluate the hemostatic effect.

Materials and Methods:
In this study, we conducted a retrospective review of patients visiting our department between June 2013 and April 2021. All patients underwent RBC transfusions for 30 days before the initiation of radiotherapy. We determined the overall survival (OS) time and RBC transfusion-free (RBCTF) time using statistical tests.

Results:
In total, 21 patients were enrolled in our study, including 13 women and 8 men; the median patient age was 63 years (range: 32–82 years). After radiotherapy, 19 of the 21 patients had a decreased frequency of requirement for RBC transfusion compared to that before radiotherapy. Fourteen patients had achieved an RBCTF state 1 month after radiotherapy. The estimated 1-year OS and RBCTF rates were 36.3% (95% confidence interval [CI]: 14.2%) and 66.7% (95% CI: 42.5%–42.5%), respectively.

Conclusion:
The present study revealed a reduction in RBC transfusion after palliative radiotherapy in patients with malignant tumor bleeding. We believe that reducing the frequency of blood transfusions in patients with terminal conditions would have significant clinical benefits.
Immunotherapy in cancer patients with chronic hepatitis C viral infection
Authors: Zakurdaeva Kristina , Tsimafeyeu Ilya 
Published: July 2022

ABSTRACT
Disease management in challenging patient population with cancer and concomitant serious conditions presents an unmet clinical need. The major gap is the lack of data from properly designed trials that could support clinical decisions. Despite many advances in the fields of oncology, immunology, and infectious diseases, chronic viral infections in cancer patients remain to some extent terra incognita. Therefore, many patients lose the opportunity to receive the most advanced therapy, and physicians are compelled to make treatment decisions without sufficient evidence. In this review, we discuss the utility of immunotherapy in patients with chronic hepatitis C viral infection. Limited data from several studies and case reports support the hypothesis that immune checkpoint inhibitors can be used safely and effectively in this patient population. Available results warrant further investigation of immunotherapy in infected patients. Taking into account the current state of our knowledge, expanding clinical trial eligibility should be considered by investigators and sponsors to allow patient access to novel therapies and better matching of clinical research to the real-world population.
Coexisting ovarian serous cystadenoma with fibroma: A very unusual combination
Authors: Balhara Kirti , Mallya Varuna , Khurana Nita , Tempe Anjali 
Published: July 2022

ABSTRACT
Surface epithelial neoplasms are the most common ovarian tumors, constituting around 60% of all ovarian malignancies. They are classified as benign, borderline, and malignant. Ovarian cystadenomas are common benign epithelial neoplasms which carry an excellent prognosis. Ovarian thecoma-fibroma groups are uncommon sex cord-stromal neoplasms, constituting 1.0%–4.0% of all ovarian tumors. Most of them are benign and often found in postmenopausal patients. Combination tumors in the ovary are known. The most common combination is mucinous cystadenoma which occurs in association with Brenner tumor, mature cystic teratoma, Sertoli-Leydig cell tumor, or even a serous cystadenoma. A combination of surface epithelial and thecoma-fibroma group is very rarely encountered. A case of one such combination of serous cystadenoma and fibroma of the ovary is being presented here in a postmenopausal woman.
Approach to the Current Rational Use of Antibiotics among the Albanian Dentist Community
Authors: Kleva Shpati , Elona Kongo , Edit Xhajanka , Anis Thodhorjani , Neada Hysenaj , Suida Kuka 
Published: July 2022

Rising antibiotic use is a serious threat to the success of therapy in dentistry for bacterial resistance and side effects to the patients. The dentist community in Albania prescribing too many antibiotics. This survey assesses the mode of antibiotic use among Albanian dentists, with appropriate dosage and regimen, and antibiotic stewardship and their knowledge of relevant guidelines.

Material and Methods:
This survey study was conducted among 180 Albanian dentists. The questionnaire was distributed through e-mail addresses found in the database of the Faculty of Dental Medicine, University of Medicine of Tirana. We assessed 180 dentists out of which 154 (85.56%) completed the entire questionnaire.

Results:
There were 24,870 prescriptions in adult patients from 154 dentists for a period of six months with an average of 1,243 prescriptions per week. The most used antibiotics were fixed combinations of amoxicillin–clavulanic acid (67.43%) and azithromycin (39.3%) for allergic patients to beta-lactams. The results for antibiotic stewardship were incorrect in 37.01% of total providers, and gastrointestinal disorders were reported as side effects.

Conclusion:
This survey conducted among Albanian dentists shows a different trend of using antibiotics than in other countries. To tackle the current antibiotic resistance, dentists must be an important part of the antimicrobial stewardship program of the Public Health Institution in Albania to change individual behavior.
Scoping Review of Six Retrospective Studies
Authors: Sadeq Adel , Elnour Asim Ahmed , Farah Farah Hamad , Ramadan Azza , Don Judit , Fathelrahman Ahmed Ibrahim , Alkaabi Maisoun , Baraka Mohammed , Abubakar Abubakar B. , Suliman Sasha Mohammed Elamin , Al Amoodi Abdulla , Khidir IsraaYousif , Al Kubaisi Khalid Awad , Al Mazroui Nadia 
Published: July 2022

Background:
It would be rational to describe the pattern of the clinical characteristics of the survivors and the nonsurvivors during the critical intensive-infection era of coronavirus disease 2019 (COVID-19). The explicit objective of the current scoping review was to delineate the predictive risk factors associated with case fatality rate (CFR).

Methods:
Six retrospective studies of subjects infected with COVID-19 published between December 1, 2020, and March 30, 2020, describing nonsurvivors in Wuhan/Hubei, China, were identified.

Results:
There were 1769 subjects with a mean age of 52 years, and 65.9% were male. The highest comorbidity reported was cardiovascular diseases at 22.2% (393/1769). The overall number of cases admitted to the intensive care unit was 228 (12.9%). The reported overall CFR was 7.7% (136/1769), with the highest at 28.2% (54/191), and the lowest at 1.4% (15/1099). The mean duration of onset until death for nonsurvivors was 15.3 days.

Conclusion:
We have found that older age, male gender, the longer duration from onset till death (days), development of acute respiratory distress syndrome/shock, preexisting diabetes, and preexisting cardiovascular diseases were the major risk factors associated with high CFR.
Fornix deepening reconstruction in conjunctivochalasis surgery
Authors: Cheng Anny M. S. , Mead Olivia G. , Tighe Sean , Tseng Scheffer C. G. 
Published: July 2022

PURPOSE:
To assess the extent of inferior fornix shortening in conjunctivochalasis (CCh) and to evaluate whether fornix deepening reconstruction can restore the fornix tear reservoir in patients with CCh.

MATERIALS AND METHODS:
This was a retrospective review of five patients (3 unilateral and 2 bilateral eyes, total 7 eyes) with CCh who underwent fornix deepening reconstruction with conjunctival recession and amniotic membrane transplantation. Postsurgical outcome measures included changes in fornix depth with correlation to basal tear volumes, symptoms, corneal staining, and conjunctival inflammation.

RESULTS:
For the three patients with unilateral surgery, both the fornix depth (8.3 ± 1.5 mm) and wetting length (9.3 ± 8.5 mm) of the operative eyes were less than the fellow eyes (10.3 ± 1.5 mm and 10.3 ± 8.5 mm, respectively). At 5.3 ± 2.7 months (range 1.7–8.7) postoperatively, the fornix depth increased significantly by 2.0 ± 1.1 mm (P = 0.02). Deepening of the fornix depth was accompanied by overwhelming symptomatic relief (91.5%) that could be subdivided into complete relief (87.5%) and partial relief (4%) of symptoms, with blurred vision being the most notably relieved symptom (P = 0.03). Furthermore, superficial punctate keratitis and conjunctival inflammation were significantly improved at follow-up (P = 0.008 and 0.05, respectively).

CONCLUSION:
Deepening of the fornix to restore the tear reservoir is an important surgical objective that may change the tear hydrodynamic state to provide a stable tear film and improve outcomes in CCh.
O Empowerment na doença cónica: revisão integrativa da literatura
Authors: Luz Elisabete Lamy da , Bastos Fernanda dos Santos , Vieira Margarida Maria Silva 
Published: July 2022

A intencionalidade da intervenção de Enfermagem na doença crónica é capacitar a pessoa a tomar decisões informadas e gerir a sua doença crónica. O Empowerment poderá ser um dos resultados desejáveis no processo de autogestão da doença crónica. Com o intuito de aprofundar a problemática optou-se por elaborar a revisão integrativa da literatura. Objetivo: Caracterizar e sintetizar a produção científica relativamente ao conceito de Empowerment e sua aplicação às situações crónicas de saúde no período de 2007-2013, no cuidado de Enfermagem. Metodologia: Revisão integrativa da literatura. Resultados: Identificação de 27 artigos que corresponderam aos critérios previamente estabelecidos, os mesmos caracterizam o Empowerment , no contexto da doença crónica, como sendo um processo, um resultado e uma intervenção educativa participativa. Conclusões: A evidência científica nesta área aponta para a necessidade de desenvolver e aprofundar o conhecimento da mesma, sobretudo da sua aplicação à Enfermagem, como disciplina, profissão e área do conhecimento. A avaliação do Empowerment como resultado permite identificar estratégias e intervenções de Enfermagem inovadoras que contribuam para a capacitação em saúde.
Efecto fisiológico de la aplicación postparto de dos diferentes dosis de ácido acetilsalicílico en vacas de doble propósito en Tuxpan, Veracruz
Authors: Lammoglia-Villagómez Miguel Ángel , Chagoya-Fuentes Jorge Luis , González-Vargas Baldemar , Sánchez-Montes Daniel Sokani , López Castro Rubén Dario 
Published: July 2022

Se determinó el efecto de dos dosis de ácido acetilsalicílico (AAS), en la producción de leche (PL), concentración de glucosa (CG) en sangre y días a primer servicio (DPS) en vacas sanas de doble propósito. Se seleccionaron al azar 30 vacas y se dividieron en tres grupos de 10 individuos cada uno: Control sin tratamiento (C); grupo dosis alta (DA; 7 g/24 hrs/VO) y grupo dosis baja (DB; 5 g/24 hrs/VO). Posterior a su aplicación se monitorearon los siguientes indicadores: Temperatura Rectal (TR), Condición Corporal (CC; escala del 1–5); Mastitis Subclínica (MS), metritis (M), CG, DPS y PL. El análisis estadístico se realizó utilizando el modelo ANOVA. Los resultados indicaron que las vacas con DA tuvieron mayor (P<0.05) PL, seguidas por las DB y con menor producción las del grupo C (8.2±0.45; 6.6±0.43 y 5.6±0.43 kg, respectivamente). Las vacas DB tuvieron mayores CG (P<0.05) que las DA y C (37.94±2.65; 33.5±2.65 y 34.0±2.65 mg/dl, respectivamente). Adicionalmente, las vacas con DB perdieron (P<0.05) menos CC que las demas. Por el contrario, la TR, los DPS y el número de casos de M, fueron similares (P>0.05). Finalmente, las vacas con DA presentaron menos MS (P < 0.05), seguidas por DB y las control. En conclusión, el tratamiento con la DA de AAS durante tres días consecutivos al parto mejoró la producción de leche y redujo el número de casos de MS, comparado con la DB y C, pero no redujo las vacas con M o los DPS.
Pengaruh Kartu Pintar Ibu Terhadap Kewaspadaan Ibu Pada Anak Diare Masa Pandemi Covid-19 di Lubuklinggau
Authors: Wijaya Sapondra , Dwi Ari Wibowo Wahyu , Susmini Susmini 
Published: July 2022

Background: The spread of Covid-19 during a pandemic is a problem that is of the utmost concern. One of the activities that are at risk of being infected with Covid-19 is going out of the house and visiting health facilities which are the most frequently done. One of the groups who are susceptible to disease are children. Many diseases that often occur in children, including diarrhea. When a child has diarrhea, mother will take the child to a health facility, even though there are the prone place to Covid-19 transmission. Therefore, there is a need for socialization about mother’s vigilance of diarrhea in children at home, so that mothers can make the best decisions for their children.
Purpose: The purpose of this study was to determine the effect of the Mother's Smart Card, which is a simplification of the MTBS book, on maternal vigilance in the management of children with diarrhea in the pre-hospital phase.
Methods: This study used a quasi-experimental design with a pre and post-test approach with purposive sampling technique on 30 mothers. Mother's vigilance is measured by the way the mother behaves and the mother's accuracy in making decisions when the child has diarrhea. The measurement uses a questionnaire
Results: The results of data analysis using paired t-test showed that there was a significant effect of the Mother's Smart Card on maternal alertness in the management of children with diarrhea at home with a p value of 0.000.
Conclusion: This means that the Mother's Smart Card can increase mother's vigilance in the management of pre-hospital child diarrhea. With this result, it is hoped that the Smart Mother Card can be a reference in increasing mother’s vigilance, and minimizing treatment at inappropriate health facilities that can put the risk of Covid-19 transmission at risk.
Un enfoque bibliométrico a los procedimientos gráficos como método de investigación
Authors: López-Chao Vicente , Amado Antonio , Miotto Bruscato Underléa 
Published: July 2022

Este artículo profundiza en el papel de la Expresión Gráfica Arquitectónica como disciplina científica, por lo que su objetivo consiste en examinar la aceptación de procedimientos de análisis gráficos en arquitectura como método científico. Para ello, se analizan 318 publicaciones del personal docente e investigador del área EGA en escuelas de arquitectura de universidades públicas. Éstas se analizan según su contenido, presencia en la revista EGA, tipología de aportación gráfica y método de investigación gráfico, así como la relación entre las mismas. Las conclusiones más importantes demuestran una amplia aceptación del método gráfico como herramienta de análisis científico en publicaciones diferentes a la revista EGA.
Influence of Electron Mediator on Microbiologically Influenced Corrosion Behavior of 2024 Aluminum Alloy
Authors: Ding Qingmiao , Liu Ruiyang , Cui Yanyu , Yan Qun , Li Xiaoman 
Published: July 2022

In microbiologically influenced corrosion (MIC) caused by sulfate-reducing bacteria (SRB), extracellular electron transfer (EET) between metals and microorganisms affects the metal corrosion process. In this work, the effect of the electron mediator riboflavin on the EET-MIC behavior of 2024 aluminum alloy (AA2024) was investigated by electrochemical methods, surface analysis techniques, focused ion beam, scanning electron microscopy, and x-ray photoelectron spectroscopy techniques. The results showed that the electron mediator was significantly able to accelerate SRB attack against AA2024. SRB utilized to consume H+ to accelerate its own metabolism and promoted the corrosion of AA2024, resulting in the formation of corrosion product AlOOH and Al(OH)3. The addition of electron mediator riboflavin increased the electron transfer efficiency and affected the reaction rate constant to accelerate the corrosion rate of aluminum alloy. The addition of 10 ppm riboflavin led to denser corrosion product biofilms on the surface of the aluminum alloy, which accelerated the formation of NaAlO2. Cl− diffused into the film layer through the pores of the surface of the aluminum alloy and was adsorbed into the film layer to induce pitting corrosion on the surface of the aluminum alloy. A large amount of SRB was attached, which resulted in an increasing pit depth on the surface of the aluminum alloy. Riboflavin accelerated the electron transfer process from the surface of the aluminum alloy across the cell wall to the cytoplasm, which led to serious corrosion of the aluminum alloy. The distribution of SRB in biofilm and the longitudinal distribution of bacteria in the process of pitting corrosion showed that the addition of electron mediators increased the depth of pits in aluminum alloys. Bacteria in the pitting area gathered at the bottom of the biofilm, and the pits were rich in Ca, P, and other elements.
Associations between muscular strength and vertical jumping performance in adolescent male football players
Authors: França Cíntia , Marques Adilson , Ihle Andreas , Nuno João , Campos Pedro , Gonçalves Frederica , Martins João , Gouveia Élvio R. 
Published: July 2022

PurposeThis study aimed to investigate the associations between muscular strength tests and vertical jumping performance (countermovement jump [CMJ] and squat jump [SJ]) in adolescent male football players, while controlling for important predictors such as chronological age and body composition.MethodsThe sample involved 161 male footballers (mean age: 15.8 ± 1.7 years) from the under-19, under-17, and under-15 age groups. Body fat percentage (BF%) was calculated with Slaughter equations. Muscular strength assessment included handgrip strength and push-up and sit-up tests. Vertical jumping was examined through CMJ and SJ. Pearson correlations and hierarchical regression analyses were run to analyse the data.ResultsAll muscular strength tests showed significant correlations with CMJ and SJ. Handgrip strength was the most substantial predictor for CMJ (<i>r</i> = 0.43, <i>p</i> < 0.01) and SJ (<i>r</i> = 0.44, <i>p</i> < 0.01). However, regression models identified sit-ups (CMJ: β = 0.15, <i>p</i> < 0.01, <i>R<sup>2</sup></i> = 0.23; SJ: β = 0.16, <i>p</i> < 0.01, <i>R<sup>2</sup></i> = 0.27) and push-ups (CMJ: β = 0.13, <i>p</i> < 0.01; SJ: β = 0.15, <i>p</i> < 0.01) as significant predictors after controlling for chronological age, body mass, and BF%. In contrast, BF% remained a significant predictor of jumping performance (CMJ: β = –0.43, <i>p</i> < 0.01, <i>R<sup>2</sup></i> = –0.39; SJ: β = –0.52, <i>p</i> < 0.01, <i>R<sup>2</sup></i> = –0.52) in the whole hierarchical regression model.ConclusionsThis study reinforces the importance of players’ overall physical development, including healthy diet habits, to enhance jumping performance.
Types of extremist activity and problems of resocialization of extremists in the penitentiary system of the Russian Federation
Authors: Оганесян С.С. 
Published: July 2022

В статье рассматриваются виды экстремистской деятельности, перечисленные в законодательных актах Российской Федерации, а также данные в них определения экстремизма и терроризма, которые имеют существенное значение для уголовно-исполнительной системы, специфика каждого из реально существующих в жизни современных социумов разновидностей экстремизма. Отмечается, что к решению проблем, связанных с ресоциализацией экстремистов и террористов, представляющих самые различные направления, необходим системный подход,и одним заключением в тюрьму эту проблему не решить. Необходимо разработать систему психолого-педагогических мер по ресоциализации таких осужденных с учетом специфики той разновидности экстремизма и терроризма, приверженцами которых они являются.
The article discusses the type of extremist activity listed in the legislative acts of Russian Federation, also definitions of extremism and terrorism, which have great importance for penal system, as well as the specifics of each of the varieties of extremism that really exist in the life of modern society. It is noted that a systematic approach is needed to solve the problems associated with the resocialization of extremists and terrorists. But this problem cannot be solved by an imprisonment. It’s necessary to develop a system of psychological and pedagogical measures for the resocialization of such convicts, taking into the specifics of the variety of extremism and terrorism to which they are adherented.