bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indigenous agriculture at the beginning of the twenty-first century: the Guaraní Mbyás minority conserves ethnoknowledge and agrobiodiversity within the remnants of the Brazilian Atlantic Forest
Authors: Fernandes Lucas Mazzero , Visscher Anna Maria , do Couto Hilton Thadeu Zarato , Marcusso Gabriel Mendes , Righi Ciro Abbud 
Published: October 2022

AbstractSwidden agricultural practices reflect a great deal of Indigenous and traditional ethnobotanical knowledge; however, such system and livelihoods are in decline worldwide and tend to disappear. This study aimed to survey the main characteristics of land use and agrobiodiversity of the swidden culture practiced by the Guaraní, in Serra do Mar (São Paulo state, Southeast Brazil). We likewise studied the socioeconomic and cultural characteristics of the Guaraní, focusing specifically on their ethnobotanical knowledge, to help conserve traditional agricultural practices in the deep tropics. A total of eighteen ethnobotanical surveys were carried out on 18 production units (10 × 10 m) in the cultivation phase after combustion took place. All species of agricultural use were indicated by the smallholders and identified to species level. Semi-structured interviews based on the design and diagnosis method World Agroforestry Centre (ICRAF) were carried out in either Portuguese or the native language with 48 smallholders in the village. Main topics discussed were the history of each sampled plot, socio-economic aspects of the production units, aspects of agricultural management to characterize the level of intensification, and forms of managing vegetation and criteria for making decisions about the maintenance of wild species in the agricultural plots. The ethnobotanical survey showed 65 varieties of plants for agricultural use, totaling 39 species, they are used for cultural-ritualistic, ecological, food, economic, medicinal, and ornamental aspects. Main crops found were corn (Zea mays), potato (Solanum tuberosum) and peanut (Arachis hypogaea). Fire is vital for Guarani’s agricultural practices. Fields are small and occupy just 0.25% of the indigenous land. The Guaraní’s traditional agroforest systems are independent of external inputs and are important for conservation of seeds and agrobiodiversity. There are three factors that maintain the dynamics of Guarani’s agricultural systems, namely: religiosity, the network of kinships and the existence of legal owned territories. Swidden and slash and mulch systems are part of the maintenance of the cultural autonomy of the Guaraní, providing them with a way to obtain financial and food resources directly and indirectly from the biome in a sustainable way. Hence, protecting this ethnoecology guarantees the cultural, physical, and social existence of the Guaraní and likewise helps to conserve the remnants of the Atlantic Forest hotspot.
Cancer survival differentials for Aboriginal and Torres Strait Islander peoples in Queensland: the impact of remoteness
Authors: Cramb S. M. , Whop L. J. , Garvey G. , Baade P. D. 
Published: October 2022

Abstract
Purpose
In Australia, Aboriginal and Torres Strait Islander peoples (First Nations population) often have low overall cancer survival, as do all residents of geographically remote areas. This study aimed to quantify the survival disparity between First Nations and other Queenslanders for 12 common cancer types by remoteness areas.

Methods
For all Queensland residents aged 20–89 years diagnosed with a primary invasive cancer during 1997–2016, we ran flexible parametric survival models incorporating age, First Nations status, sex, diagnosis time period, area-level socioeconomic status, remoteness categories and where appropriate, broad cancer type. Three survival measures were predicted: cause-specific survival, survival differences and the comparative survival ratio, each standardised to First Nations peoples’ covariate distributions.

Results
The standardised five-year cause-specific cancer survival was 60% for urban First Nations and 65% for other Queenslanders, while remote residents were 54% (First Nations) and 58% (other). The absolute survival differential between First Nations and other Queenslanders was often similar, regardless of remoteness of residence. The greatest absolute difference in five-year standardised cancer survival was for head and neck cancers, followed by cervical cancer.
The five-year comparative survival ratio (First Nations: other Queenslanders) for urban cancer patients was 0.91 (95% CI 0.90–0.93), similar to outer regional, inner regional and remote areas. The greatest comparative survival differential was for oesophageal cancer.

Conclusion
First Nations’ survival inequalities are largely independent of geographical remoteness. It remains a priority to determine the contribution of other potential factors such as the availability of culturally acceptable diagnostic, management and/or support services.
Molecular and crystal structures of cellulose in severely deteriorated archaeological wood
Authors: Guo Juan , Chen Jiabao , Meng Qiulu , Ploszczanski Leon , Liu Jian’an , Luo Rupeng , Jin Tao , Siedlaczek Philipp , Lichtenegger Helga C. , Yin Yafang , Rennhofer Harald 
Published: October 2022

AbstractPreservation and conservation of archaeological wooden artifacts is extremely challenging due to a lack of knowledge about the hierarchical structure of preserved cellulose. Herein we report on the comparative analysis of eight archaeological and four recent wood samples from three archaeological sites in China by a variety of methods, including micro-morphology, Fourier Transform Infrared Spectrum, X-ray scattering, chromatographic analysis of wood sugars, and solid state 13C CP/MAS NMR. Results show that deterioration on the microscale is clearly related to a fragmentation of both the cellulose crystallite structure and the cellulose microfibrils. Slightly deteriorated archaeological wood features cellulose crystallites and microfibrils, comparable to non-degraded recent wood, whereas severely deteriorated wood shows higher porosity of the wood cell wall, fragmented cellulose aggregates instead of fibrils and nearly no crystallinity. Alterations in molecular structures resulted in advanced degradation of both amorphous and crystalline cellulose domains. Only a small amount of cellulose was preserved. The data allows to assume highly fragmented but still partially crystalline cellulose lamellas.

Graphical abstract
Cohort profile: the Food Chain Plus (FoCus) cohort
Authors: Geisler Corinna , Schlicht Kristina , Knappe Carina , Rohmann Nathalie , Hartmann Katharina , Türk Kathrin , Settgast Ute , Schulte Dominik M. , Demetrowitsch Tobias , Jensen-Kroll Julia , Pisarevskaja Alina , Brix Fynn , Gruber Bärbel , Rimbach Gerald , Döring Frank , Rosenstiel Philip , Franke Andre , Schreiber Stefan , Henning Christian H. C. A. , Lieb Wolfgang , Nöthlings Ute , Schwarz Karin , Laudes Matthias 
Published: October 2022

AbstractThe Food Chain Plus (FoCus) cohort was launched in 2011 for population-based research related to metabolic inflammation. To characterize this novel pathology in a comprehensive manner, data collection included multiple omics layers such as phenomics, microbiomics, metabolomics, genomics, and metagenomics as well as nutrition profiling, taste perception phenotyping and social network analysis. The cohort was set-up to represent a Northern German population of the Kiel region. Two-step recruitment included the randomised enrolment of participants via residents’ registration offices and via the Obesity Outpatient Centre of the University Medical Center Schleswig–Holstein (UKSH). Hence, both a population- and metabolic inflammation- based cohort was created. In total, 1795 individuals were analysed at baseline. Baseline data collection took place between 2011 and 2014, including 63% females and 37% males with an age range of 18–83 years. The median age of all participants was 52.0 years [IQR: 42.5; 63.0 years] and the median baseline BMI in the study population was 27.7 kg/m2 [IQR: 23.7; 35.9 kg/m2]. In the baseline cohort, 14.1% of participants had type 2 diabetes mellitus, which was more prevalent in the subjects of the metabolic inflammation group (MIG; 31.8%). Follow-up for the assessment of disease progression, as well as the onset of new diseases with changes in subject’s phenotype, diet or lifestyle factors is planned every 5 years. The first follow-up period was finished in 2020 and included 820 subjects.
Media’s portrayal of large predators in Norway from the protection by law in the 1970’s till today: an insight into local and national newspapers
Authors: Sponberg Vilde Bech , Mathiesen Kristin E. 
Published: October 2022

AbstractIn the late century of 1800 till mid-1900s, large predators were eradicated worldwide, and bounties were commonly used to get rid of the predators. In the twentieth century the policy changed, and predators became protected by law. The “return” of the predators has resulted in negative human–wildlife interactions and an increase in social conflicts. Media plays a key role in most social conflicts, as positive portrayals can lead to an increased willingness to conserve the species, as opposed to negative portrayals. We have looked at how Norwegian newspapers portray the large predators from when they were protected by law in the 1970’s till today. Our results show that wolves represent the most articles, and the positive mentioning of wolves has decreased, while for bears this has increased. Local newspapers contained more negative portrayals than national newspapers, and changes in wolf establishment, predator management or politics impact on the number of articles. As our findings indicate that negative experiences with predators, in particular in local areas, associate with negative articles in the local newspapers, we believe this could contribute to negative attitudes towards predators among those who are readers of the local newspapers. This is yet to be studied in more detail and would be recommended to better understand the role of media in human–wildlife conflicts.
Development of a new critical size defect model in the paranasal sinus and first approach for defect reconstruction—An in vivo maxillary bone defect study in sheep
Authors: Rothweiler R. , Kuhn S. , Stark T. , Heinemann S. , Hoess A. , Fuessinger M. A. , Brandenburg L. S. , Roelz R. , Metzger M. C. , Hubbe U. 
Published: October 2022

AbstractFractures of the paranasal sinuses often require surgical intervention. Persisting bone defects lead to permanent visible deformities of the facial contours. Bone substitutes for reconstruction of defects with simultaneous induction of new bone formation are not commercially available for the paranasal sinus. New materials are urgently needed and have to be tested in their future area of application. For this purpose critical size defect models for the paranasal sinus have to be developed. A ≥2.4 cm large bilateral circular defect was created in the anterior wall of the maxillary sinus in six sheep via an extraoral approach. The defect was filled with two types of an osteoconductive titanium scaffold (empty scaffold vs. scaffold filled with a calcium phosphate bone cement paste) or covered with a titanium mesh either. Sheep were euthanized after four months. All animals performed well, no postoperative complications occured. Meshes and scaffolds were safely covered with soft tissue at the end of the study. The initial defect size of ≥2.4 cm only shrunk minimally during the investigation period confirming a critical size defect. No ingrowth of bone into any of the scaffolds was observed. The anterior wall of the maxillary sinus is a region with low complication rate for performing critical size defect experiments in sheep. We recommend this region for experiments with future scaffold materials whose intended use is not only limited to the paranasal sinus, as the defect is challenging even for bone graft substitutes with proven osteoconductivity.
Predicting the flammability of epoxy resins from their structure and small-scale test results using an artificial neural network model
Authors: Pomázi Ákos , Toldy Andrea 
Published: October 2022

AbstractDeveloping optimal flame retardant polymer compositions that meet all aspects of a given application is energy and cost-intensive. To reduce the number of measurements, we developed an artificial neural network-based system to predict the flammability of polymers from small-scale test data and structural properties. The system can predict ignition time, peak and total heat release, and mass residue after the burning of reference and flame retarded epoxy resins. Total heat release was predicted most accurately, followed by the peak heat release rate. We ranked the input parameters according to their impact on the output parameters using a sensitivity analysis. This ranking allowed us to establish a relationship between the input and output parameters taking into account their physical content.
Identification of phytochemical as a dual inhibitor of PI3K and mTOR: a structure-based computational approach
Authors: Kumar B. Harish , Manandhar Suman , Choudhary Sneha Sunil , Priya Keerthi , Gujaran Tanvi V. , Mehta Chetan Hasmukh , Nayak Usha Yogendra , Pai K. Sreedhara Ranganath 
Published: October 2022

AbstractBreast cancer is a common form of cancer that affects both men and women. One of the most common types of genomic flaws in cancer is the aberrations in the PI3K/AKT/mTOR pathway. The benefit of dual targeting PI3K as well as mTOR is that the kinase-positive feedback loops are more effectively inhibited. Therefore, in the current study, structure-based models like molecular docking, MM-GBSA, Qikprop, induced fit docking, simulated molecular dynamics (MD), and thermal MM-GBSA were used to identify the phytochemicals from the zinc 15 database, which may inhibit PI3K and mTOR. After docking the phytochemicals with PI3K (PDB 4FA6), ten ligands based on the docking score were selected, among which salvianolic acid C had the highest docking score. Hence, salvianolic acid A was also docked. All the ligands taken showed a binding energy of greater than − 30 kcal/mol. The predicted ADME showed that the ligands have druggable properties. By performing MD of the top five ligands and salvianolic acid A, it was found that ZINC000059728582, ZINC000257545754, ZINC000253532301, and salvianolic acid A form a stable complex with PI3K protein, among which ZINC000014690026 showed interaction with Val 882 for more than 89% of the time. Salvianolic acid A is already proven to suppress tumor growth in acute myeloid leukemia by inhibiting PI3K/AKT pathway, but the exact protein target is unknown. Therefore, the present study identifies new molecules and provides evidence for salvianolic acid A for dual inhibition. Further experiments must be performed both in vitro and in vivo to support the predictions of these computational tools.
Graphical abstract
Overview Article Astrocytes as Initiators of Epilepsy
Authors: Henning Lukas , Unichenko Petr , Bedner Peter , Steinhäuser Christian , Henneberger Christian 
Published: October 2022

AbstractAstrocytes play a dual role in the brain. On the one hand, they are active signaling partners of neurons and can for instance control synaptic transmission and its plasticity. On the other hand, they fulfill various homeostatic functions such as clearance of glutamate and K+ released from neurons. The latter is for instance important for limiting neuronal excitability. Therefore, an impairment or failure of glutamate and K+ clearance will lead to increased neuronal excitability, which could trigger or aggravate brain diseases such as epilepsy, in which neuronal hyperexcitability plays a role. Experimental data indicate that astrocytes could have such a causal role in epilepsy, but the role of astrocytes as initiators of epilepsy and the relevant mechanisms are under debate. In this overview, we will discuss the potential mechanisms with focus on K+ clearance, glutamate uptake and homoeostasis and related mechanisms, and the evidence for their causative role in epilepsy.
Robotic transanal excision of rectal lesions: expert perspective and literature review
Authors: Watanaskul Sarah , Schwab Marisa E. , Chern Hueylan , Varma Madhulika , Sarin Ankit 
Published: October 2022

AbstractTransanal excision of benign lesions, moderately or well-differentiated rectal T1 adenocarcinomas is typically completed via transanal endoscopic microsurgery (TEM) or laparoscopic transanal minimally invasive surgery (TAMIS). Robotic platforms provide ergonomic comfort in an enclosed space, enhanced range of motion, and superior 3D visualization. This study sought to perform a literature review of robotic TAMIS (R-TAMIS) and provide expert commentary on the technique. A Pubmed literature search was performed. Study design, robot type, indication, techniques compared, surgical margins, conversion, complications, operative time, estimated blood loss, patient positioning, and defect closure were collected from included articles. Expert opinion on pre-operative planning, technical details, and possible pitfalls was provided, with an accompanying video. Twelve articles published between 2013 and 2022 were included. Five were case reports, three case series, two prospective cohort studies, one retrospective cohort study, and one Phase II trial. The Da Vinci Si (n = 3), Xi (n = 2), single port (n = 3) and flex robotic system (n = 2) were used. Five studies reported negative surgical margins, one reported positive margins, and six did not comment. Operating room time ranged from 45 to 552 min and EBL ranged from 0 to 100 mL. Patient positioning varied based on lesion location but included supine, prone, modified lithotomy, and prone jackknife positions. 11/12 studies reported defect closure, most commonly with V-Loc absorbable suture. We recommend pre-operative MRI abdomen/pelvis, digital rectal exam, and rigid proctoscopy; prone jackknife patient positioning to avoid collisions with robotic arms; and defect closure of full-thickness excisions with backhanded running V-Loc suture.
A Scoping Review of the Literature On Prosodic Elements Related to Emotional Speech in Human-Robot Interaction
Authors: Gasteiger Norina , Lim JongYoon , Hellou Mehdi , MacDonald Bruce A. , Ahn Ho Seok 
Published: October 2022

AbstractBackgroundSentiment expression and detection are crucial for effective and empathetic human-robot interaction. Previous work in this field often focuses on non-verbal emotion expression, such as facial expressions and gestures. Less is known about which specific prosodic speech elements are required in human-robot interaction. Our research question was: what prosodic elements are related to emotional speech in human-computer/robot interaction?MethodsThe scoping review was conducted in alignment with the Arksey and O’Malley methods. Literature was identified from the SCOPUS, IEEE Xplore, ACM Digital Library and PsycINFO databases in May 2021. After screening and de-duplication, data were extracted into an Excel coding sheet and summarised.ResultsThirteen papers, published from 2012 to 2020 were included in the review. The most commonly used prosodic elements were tone/pitch (n = 8), loudness/volume (n = 6) speech speed (n = 4) and pauses (n = 3). Non-linguistic vocalisations (n = 1) were less frequently used. The prosodic elements were generally effective in helping to convey or detect emotion, but were less effective for negative sentiment (e.g., anger, fear, frustration, sadness and disgust).DiscussionFuture research should explore the effectiveness of commonly used prosodic elements (tone, loudness, speed and pauses) in emotional speech, using larger sample sizes and real-life interaction scenarios. The success of prosody in conveying negative sentiment to humans may be improved with additional non-verbal cues (e.g., coloured light or motion). More research is needed to determine how these may be combined with prosody and which combination is most effective in human-robot affective interaction.
Frailty and risk of hospitalization from COVID-19 infection among older adults: evidence from the Dutch Lifelines COVID-19 Cohort study
Authors: Zhu Yinjie , Sealy Martine J. , Jager-Wittenaar Harriët , Mierau Jochen O. , Bakker Stephan J. L. , Navis Gerjan J. ,   Lifelines Corona Research Initiative, Boezen H. Marike , Mierau Jochen O. , Franke H. Lude , Dekens Jackie , Deelen Patrick , Lanting Pauline , Vonk Judith M. , Nolte Ilja , Ori Anil P. S. , Claringbould Annique , Boulogne Floranne , Dijkema Marjolein X. L. , Wiersma Henry H. , Warmerdam Robert , Jankipersadsing Soesma A. , van Blokland Irene , de Bock Geertruida H. , Rosmalen Judith G. M. , Wijmenga Cisca 
Published: October 2022

Abstract
Background
Frailty is associated with COVID-19 severity in clinical settings. No general population-based studies on the association between actual frailty status and COVID-19 hospitalization are available.

Aims
To investigate the association between frailty and the risk of COVID-19 hospitalization once infected.

Methods
440 older adults who participated in the Lifelines COVID-19 Cohort study in the Northern Netherlands and reported positive COVID-19 testing results (54.2% women, age 70 ± 4 years in 2021) were included in the analyses. COVID-19 hospitalization status was self-reported. The Groningen Frailty Indicator (GFI) was derived from 15 self-reported questionnaire items related to daily activities, health problems, and psychosocial functioning, with a score ≥ 4 indicating frailty. Both frailty and COVID-19 hospitalization were assessed in the same period. Poisson regression models with robust standard errors were used to analyze the associations between frailty and COVID-19 hospitalization.

Results
Of 440 older adults included, 42 were hospitalized because of COVID-19 infection. After adjusting for sociodemographic and lifestyle factors, a higher risk of COVID-19 hospitalization was observed for frail individuals (risk ratio (RR) [95% CI] 1.97 [1.06–3.67]) compared to those classified as non-frail.

Discussion
Frailty was positively associated with COVID-19 hospitalization once infected, independent of sociodemographic and lifestyle factors. Future research on frailty and COVID-19 should consider biomarkers of aging and frailty to understand the pathophysiological mechanisms and manifestations between frailty and COVID-19 outcomes.

Conclusions
Frailty was positively associated with the risk of hospitalization among older adults that were infected with COVID-19. Public health strategies for frailty prevention in older adults need to be advocated, as it is helpful to reduce the burden of the healthcare system, particularly during a pandemic like COVID-19.
The Repertoires of Religious Nationalism: The Case of İsmet Özel
Authors: Yıldız Tunahan , Çengel Esra 
Published: October 2022

AbstractThis article problematizes the study of religious nationalism, which lacks conceptual, religious, and nationalist “seriousness.” These problems of “seriousness” obscure the nature of religious nationalism as they overstretch and do not do justice to the concepts of religious nationalism, religion, and nationalism, respectively. Seeking for the nature of and a path to religious nationalism, it is suggested that the later writings of İsmet Özel, a well-known poet and public intellectual in Turkey, make an emblematic case for a religious type of nationalism, demonstrating not only religious seriousness with his Islamist ideology but also a central orientation to the nation through his exclusive focus on Turkishness and Turkey. In so doing, this article introduces a wide range of categories to specify the ways in which religious nationalism is operationalized and to measure the patterns of religious nationalism in an attempt to overcome the problems of “seriousness.” It identifies and examines six main patterns in Özel’s thinking and shows their interactions: religio-national identity, exceptionalism, religious territoriality, civilizational othering, sectarianism, and anti-secularism.