bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paul's Escape from Damascus (2 Cor 11.32–3) and the corona muralis
Authors: Pawlak Matthew 
Published: March 2022

AbstractIt has been often suggested that Paul's escape from Damascus (2 Cor 11.32–3) alludes to the corona muralis, a Roman military award originally given to the first soldier to surmount the enemy wall during a siege. This article evaluates this hypothesis, employing an extensive range of ancient references to the corona muralis to determine where relevant passages from Second Corinthians (10.3–5; 11.30–3) may signal an allusion to the corona muralis.
Robert Johnson and spectral timbre: what we hear, what we construct
Authors: Simon Julia 
Published: March 2022

AbstractThe myth of the deal with the devil at the crossroads frames the reception of Robert Johnson's corpus, particularly lyrics that directly or indirectly reference otherworldly forces. Setting aside the myth, I analyse the uncanny sonic qualities in his performances that evoke a spectral presence. A close examination of vocal and guitar timbre that considers harmonic resonance, chimera effect and other ‘eerie’ qualities of the music breaks down musical elements other than lyrics that evoke the myth of supernatural power. Humming, mumbling and talking, corner loading, falsetto, simultaneous rhythm and lead, among other acoustic effects, contribute to a complex soundscape with spectral resonances. Taking a lead from Johnson's mentor Ike Zimmerman and his fondness for practising in the cemetery, my analysis of timbral quality informed by Freud's concept of the uncanny seeks to explore what we hear, how it is produced and the origin that we construct for the sounds.
Is Pitcairnia halophila really a halophyte? Evidence from a germination and growth experiment
Authors: Zotz Gerhard , Rodriguez Quiel Calixto 
Published: March 2022

AbstractMany bromeliads occur in habitats that are potentially affected by salt. Pitcairnia halophila is a particularly interesting case in this context due to its growing sites in the spray zone of coastal cliffs in Central America. We conducted an experimental/observational study that explored the physiological and ecological basis of the occurrence of this species. Germination of P. halophila was as affected by increasing salinity as that of congeneric species from other natural growing sites, but seedling growth was less impaired in comparison and remained positive even at exposure to half-strength seawater. Interestingly, in situ plant nutrient concentrations documented over an entire growing season suggest that this capacity to tolerate salt stress is not tested at the natural growing site – Na+ concentrations were consistently low in leaves and shoots and comparable to those of seedlings watered with distilled water in the laboratory. We conclude that P. halophila shows the physiological ability to deal with medium levels of salinity, but ecological conditions at the humid tropical growing site allow these plants to avoid salt stress entirely in spite of the close proximity to the sea.
New ways of analyzing complementizer drop in Montréal French: Exploration of cognitive factors
Authors: Liang Yiming , Amsili Pascal , Burnett Heather 
Published: March 2022

AbstractIn this paper, we return to the well-studied yet still puzzling phenomenon of complementizer omission in a large spoken corpus of Quebec French, with the help of modern computational methods for annotation and mixed effects logistic regression models. Supporting previous work, our study reveals that complementizerqueomission is conditioned by social factors and grammatical factors; however, we also find thatqueomission is conditioned by cognitive factors such as information density. Our paper thus illustrates an important way in which older variationist corpora can continue to be valuable resources for studying fine-grained patterns of variation, particularly in their cognitive aspects.
Mary Anne Warren and the Boundaries of the Moral Community
Authors: Furlan Timothy 
Published: March 2022

AbstractIn her important and well-known discussion “On the Moral and Legal Status of Abortion,” Mary Anne Warren regrets that “it is not possible to produce a satisfactory defense of a woman’s right to obtain an abortion without showing that the fetus is not a human being, in the morally relevant sense.” Unlike some more cautious philosophers, Warren thinks that we can definitively demonstrate that the fetus is not a person. In this paper, Warren’s argument is critically examined with a focus especially on the question of the foundation and the boundaries of the moral community. The fundamental thesis of the paper is that Warren’s approach is flawed for at least four reasons: (1) that being a person is not as obviously central to having full moral rights as Warren assumes, (2) that her exclusivism regarding moral status has dubious moral consequences independent of the abortion issue, (3) that it is not clear that a fetus is not a person, even on Warren’s own criteria, and (4) her criteria for personhood are themselves suspect.
The Uncommon Ethics of the Medical Profession: A Response to My Critics
Authors: Rhodes Rosamond 
Published: March 2022

AbstractIn responding to my critics, James Childress, Tom Beauchamp, Soren Holm, and Ruth Macklin, I reprise my arguments for medical ethics being an uncommon morality. I also elaborate on points that required further clarification. I explain the role of trust and trustworthiness in the creation of a profession. I also describe my views on the relationship of the medical profession to the society in which medicine is practiced. Finally, I defend my claim that medical ethics “is constructed by medical professionals for medical professionals” by describing the profession’s unique vantage point for regulating and policing the profession’s uncommon powers and privileges.
‘They must either be informed or they will be cominformed’: Covert propaganda, political literacy, and cold war knowledge production in the Loyal African Brothers series
Authors: LoBue Adam 
Published: March 2022

AbstractThis article analyzes and narrates the history of a clandestine propaganda project known as the Loyal African Brothers series. At the height of the Cold War, African leaders of public opinion received unsolicited leaflets from a group styled the Freedom for Africa Movement (FFAM). Addressed to ‘our Loyal African Brothers,’ the leaflets decried Communist penetration of Africa by connecting topical regional and global events with local histories meant to resonate with an African readership. Unknown to the recipients was that the leaflets were in reality a fabrication of the British Foreign Office’s clandestine propaganda arm, the Information Research Department. Examining the content and distribution of the series, this article uses newly declassified documents to situate Loyal African Brothers within a global ecosystem of Cold War propaganda, decolonization, and print culture. In doing so, it positions Africa as a key battleground in the cultural front of the Global Cold War.
Phosphorus Supply Increases Nitrogen Transformation Rates and Retention in Soil: A Global Meta‐Analysis
Authors: Wang Ruzhen , Bicharanloo Bahareh , Hou Enqing , Jiang Yong , Dijkstra Feike A. 
Published: March 2022

AbstractInteractions between nitrogen (N) and phosphorus (P) are important for plant growth and ecosystem carbon (C) sequestration. While effects of N supply on P dynamics have been much studied, much less is known about the opposite (P‐effect on N). We conducted a meta‐analysis by compiling a total of 1,734 individual experimental observations from 116 peer‐reviewed publications to assess P‐addition effects on soil N dynamics. Globally, P additions increased the soil total nitrogen (TN) pool, potentially as a result of enhanced plant and microbial immobilization and reduced N losses, with a stronger effect detected under longer duration of P addition (≥5 yr). A coupled increase in soil organic C with TN signifies the fundamental role of exogenous P supply in enhancing soil C sequestration. Phosphorus addition accelerated some of the soil N cycling processes including gross N mineralization, gross nitrification, and denitrification, with the effect sizes varying among ecosystem types and increasing with P addition rates. Our results indicate the fundamental role of P in affecting soil N pools and processes, and highlight the efficacy of P supply in sequestering soil C and mitigating global C emission.
Mid‐Pleistocene to Recent Crustal Extension in the Inner Graben of the Northern Kenya Rift
Authors: Riedl S. , Melnick D. , Njue L. , Sudo M. , Strecker M. R. 
Published: March 2022

AbstractMagmatic continental rifts often constitute nascent plate boundaries, yet long‐term extension rates and transient rate changes associated with these early stages of continental breakup remain difficult to determine. Here, we derive a time‐averaged minimum extension rate for the inner graben of the Northern Kenya Rift (NKR) of the East African Rift System for the last 0.5 m.y. We use the TanDEM‐X science digital elevation model to evaluate fault‐scarp geometries and determine fault throws across the volcano‐tectonic axis of the inner graben of the NKR. Along rift‐perpendicular profiles, amounts of cumulative extension are determined, and by integrating four new 40Ar/39Ar radiometric dates for the Silali volcano into the existing geochronology of the faulted volcanic units, time‐averaged extension rates are calculated. This study reveals that in the inner graben of the NKR, the long‐term extension rate based on mid‐Pleistocene to recent brittle deformation has minimum values of 1.0–1.6 mm yr−1, locally with values up to 2.0 mm yr−1. A comparison with the decadal, geodetically determined extension rate reveals that at least 65% of the extension must be accommodated within a narrow, 20‐km‐wide zone of the inner rift. In light of virtually inactive border faults of the NKR, we show that extension is focused in the region of the active volcano‐tectonic axis in the inner graben, thus highlighting the maturing of continental rifting in the NKR.
Performance of State‐of‐the‐Art C3S European Seasonal Climate Forecast Models for Mean and Extreme Precipitation Over Africa
Authors: Gebrechorkos S. H. , Pan M. , Beck H. E. , Sheffield J. 
Published: March 2022

AbstractSeasonal hydrological forecasts at high spatial and temporal resolution can help manage water resources and mitigate impacts of extreme events but are dependent on skillful and operational seasonal forecasts from climate models. In this study, we evaluate precipitation forecasts from five operational climate models with a potential to drive hydrological forecasts: European Centre for Medium‐Range Weather Forecasts (ECMWF), UK Met Office (UK‐Met), Météo France, Deutscher Wetterdienst, and Centro Euro‐Mediterraneo sui Cambiamenti Climatici. The Multi‐Source Weighted‐Ensemble Precipitation is used as a reference data set to evaluate the model skill. The performance of individual models is evaluated on daily, weekly, monthly, seasonal, and climatological periods, and for selected target months, lead‐times and drought events, and compared to unweighted and skill‐weighted multi‐model ensemble mean forecast. For all models, the lead 1‐month forecast can replicate the climatological mean, monthly mean, and monthly anomaly precipitation, although much of this skill originates from the first week of the forecast. The skill drops rapidly for lead 2‐month and longer and is highest in drier regions and seasons. The forecast skill of monthly meteorological drought events at lead 1‐month is modest. All models represent the monthly variation in the length of wet and dry spell days at lead 1‐month, but the skill is weak for heavy and very heavy precipitation days. ECMWF is found to be the most skillful model, followed by the UK‐Met, although the multi‐model weighted average provides the highest performance compared to individual models and the un‐weighted multi‐model mean.
Integrated multi-month dispensing of antihypertensive and antiretroviral therapy to sustain hypertension and HIV control
Authors: Kimera Isaac Derickk , Namugenyi Christabellah , Schwartz Jeremy I. , Musimbaggo Douglas Joseph , Ssenyonjo Rebecca , Atukunda Praise , Mutungi Gerald , Mugabe Frank , Ambangira Fortunate , Mbuliro Mary , Katwesigye Rodgers , Neupane Dinesh , Ssinabulya Isaac , Semitala Fred Collins , Delles Christian , Muddu Martin 
Published: March 2022

AbstractMulti-month dispensing (MMD) is a patient-centered approach in which stable patients receive medicine refills of three months or more. In this pre-post longitudinal study, we determined hypertension and HIV treatment outcomes in a cohort of hypertensive PLHIV at baseline and 12 months of receiving integrated MMD. At each clinical encounter, one healthcare provider attended to both hypertension and HIV needs of each patient in an HIV clinic. Among the 1,082 patients who received MMD, the mean age was 51 (SD = 9) years and 677 (63%) were female. At the start of MMD, 1,071(98.9%) patients had achieved HIV viral suppression, and 767 (73.5%) had achieved hypertension control. Mean blood pressure reduced from 135/87 (SD = 15.6/15.2) mmHg at the start of MMD to 132/86 (SD = 15.2/10.5) mmHg at 12 months (p < 0.0001). Hypertension control improved from 73.5% to 78.5% (p = 0.01) without a significant difference in the proportion of patients with HIV viral suppression at baseline and at 12 months, 98.9% vs 99.0% (p = 0.65). Patients who received MMD with elevated systolic blood pressure at baseline were less likely to have controlled blood pressure at 12 months (OR-0.9, 95% CI, 0.90,0.92). Overall, 1,043 (96.4%) patients were retained at 12 months. Integrated MMD for stable hypertensive PLHIV improved hypertension control and sustained optimal HIV viral suppression and retention of patients in care. Therefore, it is feasible to provide integrated MMD for both hypertension and HIV treatment and achieve dual control in the setting of sub-Saharan Africa.
Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer
Authors: Jiang Huimin , Wei Huimin , Wang Hang , Wang Zhaoyang , Li Jianjun , Ou Yang , Xiao Xuechun , Wang Wenhao , Chang Antao , Sun Wei , Zhao Li , Yang Shuang 
Published: March 2022

AbstractAerobic glycolysis (the Warburg effect) has been demonstrated to facilitate tumor progression by producing lactate, which has important roles as a proinflammatory and immunosuppressive mediator. However, how aerobic glycolysis is directly regulated is largely unknown. Here, we show that ectopic Zeb1 directly increases the transcriptional expression of HK2, PFKP, and PKM2, which are glycolytic rate-determining enzymes, thus promoting the Warburg effect and breast cancer proliferation, migration, and chemoresistance in vitro and in vivo. In addition, Zeb1 exerts its biological effects to induce glycolytic activity in response to hypoxia via the PI3K/Akt/HIF-1α signaling axis, which contributes to fostering an immunosuppressive tumor microenvironment (TME). Mechanistically, breast cancer cells with ectopic Zeb1 expression produce lactate in the acidic tumor milieu to induce the alternatively activated (M2) macrophage phenotype through stimulation of the PKA/CREB signaling pathway. Clinically, the expression of Zeb1 is positively correlated with dysregulation of aerobic glycolysis, accumulation of M2-like tumor-associated macrophages (TAMs) and a poor prognosis in breast cancer patients. In conclusion, these findings identify a Zeb1-dependent mechanism as a driver of breast cancer progression that acts by stimulating tumor–macrophage interplay, which could be a viable therapeutic target for the treatment of advanced human cancers.
Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation
Authors: Fester Niclas , Zielonka Elisabeth , Goldmann Jakob , Frombach Ann-Sophie , Müller-Kuller Uta , Gutfreund Niklas , Riegel Kristina , Smits Jos G. A. , Schleiff Enrico , Rajalingam Krishnaraj , Zhou Huiqing , Simm Stefan , Dötsch Volker 
Published: March 2022

AbstractSpecialized surveillance mechanisms are essential to maintain the genetic integrity of germ cells, which are not only the source of all somatic cells but also of the germ cells of the next generation. DNA damage and chromosomal aberrations are, therefore, not only detrimental for the individual but affect the entire species. In oocytes, the surveillance of the structural integrity of the DNA is maintained by the p53 family member TAp63α. The TAp63α protein is highly expressed in a closed and inactive state and gets activated to the open conformation upon the detection of DNA damage, in particular DNA double-strand breaks. To understand the cellular response to DNA damage that leads to the TAp63α triggered oocyte death we have investigated the RNA transcriptome of oocytes following irradiation at different time points. The analysis shows enhanced expression of pro-apoptotic and typical p53 target genes such as CDKn1a or Mdm2, concomitant with the activation of TAp63α. While DNA repair genes are not upregulated, inflammation-related genes become transcribed when apoptosis is initiated by activation of STAT transcription factors. Furthermore, comparison with the transcriptional profile of the ΔNp63α isoform from other studies shows only a minimal overlap, suggesting distinct regulatory programs of different p63 isoforms.
Chameleon-inspired multifunctional plasmonic nanoplatforms for biosensing applications
Authors: Ziai Yasamin , Petronella Francesca , Rinoldi Chiara , Nakielski Paweł , Zakrzewska Anna , Kowalewski Tomasz A. , Augustyniak Weronika , Li Xiaoran , Calogero Antonella , Sabała Izabela , Ding Bin , De Sio Luciano , Pierini Filippo 
Published: March 2022

AbstractOne of the most fascinating areas in the field of smart biopolymers is biomolecule sensing. Accordingly, multifunctional biomimetic, biocompatible, and stimuli-responsive materials based on hydrogels have attracted much interest. Within this framework, the design of nanostructured materials that do not require any external energy source is beneficial for developing a platform for sensing glucose in body fluids. In this article, we report the realization and application of an innovative platform consisting of two outer layers of a nanocomposite plasmonic hydrogel plus one inner layer of electrospun mat fabricated by electrospinning, where the outer layers exploit photoinitiated free radical polymerization, obtaining a compact and stable device. Inspired by the exceptional features of chameleon skin, plasmonic silver nanocubes are embedded into a poly(N-isopropylacrylamide)-based hydrogel network to obtain enhanced thermoresponsive and antibacterial properties. The introduction of an electrospun mat creates a compatible environment for the homogeneous hydrogel coating while imparting excellent mechanical and structural properties to the final system. Chemical, morphological, and optical characterizations were performed to investigate the structure of the layers and the multifunctional platform. The synergetic effect of the nanostructured system’s photothermal responsivity and antibacterial properties was evaluated. The sensing features associated with the optical properties of silver nanocubes revealed that the proposed multifunctional system is a promising candidate for glucose-sensing applications.
COVID-19, Green Deal and recovery plan permanently change emissions and prices in EU ETS Phase IV
Authors: Bruninx Kenneth , Ovaere Marten 
Published: March 2022

AbstractThe EU emissions trading system’s (ETS) invalidation rule implies that shocks and overlapping policies can change cumulative carbon emissions. This paper explains these mechanisms and simulates the effect of COVID-19, the European Green Deal, and the recovery stimulus package on cumulative EU ETS emissions and allowance prices. Our results indicate that the negative demand shock of the pandemic should have a limited effect on allowance prices and rather translates into lower cumulative carbon emissions. Aligning EU ETS with the 2030 reduction target of −55% might increase allowance prices to 45–94 €/ton CO2 today and reduce cumulative carbon emissions to 14.2–18.3 GtCO2 compared to 23.5–33.1 GtCO2 under a −40% 2030 reduction target. Our results crucially depend on when the waterbed will be sealed again, which is an endogenous market outcome, driven by the EU ETS design, shocks and overlapping climate policies such as the recovery plan.
Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche
Authors: Patel Akshay , Wu Yicong , Han Xiaofei , Su Yijun , Maugel Tim , Shroff Hari , Roy Sougata 
Published: March 2022

AbstractAsymmetric signaling and organization in the stem-cell niche determine stem-cell fates. Here, we investigate the basis of asymmetric signaling and stem-cell organization using theDrosophilawing-disc that creates an adult muscle progenitor (AMP) niche. We show that AMPs extend polarized cytonemes to contact the disc epithelial junctions and adhere themselves to the disc/niche. Niche-adhering cytonemes localize FGF-receptor to selectively adhere to the FGF-producing disc and receive FGFs in a contact-dependent manner. Activation of FGF signaling in AMPs, in turn, reinforces disc-specific cytoneme polarity/adhesion, which maintains their disc-proximal positions. Loss of cytoneme-mediated adhesion promotes AMPs to lose niche occupancy and FGF signaling, occupy a disc-distal position, and acquire morphological hallmarks of differentiation. Niche-specific AMP organization and diversification patterns are determined by localized expression and presentation patterns of two different FGFs in the wing-disc and their polarized target-specific distribution through niche-adhering cytonemes. Thus, cytonemes are essential for asymmetric signaling and niche-specific AMP organization.