bluuebunny/crossref_metadata_2025_split huggingface dataset:
To facilitate a fair bioeconomy transition, stronger regional‐level linkages are needed
Authors: Andersen Mikael S. , Christensen Lotte D. , Donner‐Amnell Jakob , Eikeland Per O. , Hedeler Barbara , Hildingsson Roger , Johansson Bengt , Khan Jamil , Kronsell Annica , Inderberg Tor H. J. , Nielsen Helle Ø. , Pizzol Massimo , Sairinen Rauno , Skjærseth Jon B. , Söderholm Patrik , Teräväinen Tuula , Thomsen Marianne 
Published: March 2022

AbstractThe great hopes in Brussels that a circular bioeconomy will help bridge the growing divide between urban and rural areas and allow the hinterlands to prosper from ‘green growth’ are addressed in this article, which reflects on insights from three Nordic case studies of brown, green and blue biomass use at different levels of technology readiness. A closer examination of the forward, backward, fiscal and final demand linkages at regional level from increased biomass utilization, from eastern Finland and northern Sweden to Jutland and North Atlantic islands, suggests that linkages are and will remain relatively weak, predominantly dashing the expectations. As suppliers and exporters of natural resources, disadvantaged regions may all too easily get locked into a ‘staples trap’, where the value creation evaporates owing in part to the steep start‐up costs and the associated boom‐and‐bust cycles, which place them in a weak position vis‐à‐vis the resource manufacturers and consumers. To make the prospects of development, employment and prosperity in the hinterlands materialize, measures are needed to strengthen the regional‐level economic linkages. Regional‐level revolving funds based on benefit‐sharing instruments related to natural resources can be used to bolster economic development, as reflected in such schemes present in both China and Canada. We call for further research into whether and how such approaches can be replicated successfully by channeling revenues from biomass cultivation to regional‐scale revolving funds, with mandates to strengthen long‐term economic linkages and prosperity within the hinterlands. © 2022 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd
Incision‐free, coronally advanced flap with subepithelial connective tissue graft placed by the molar or canine access (MOCA) technique: 13 case series
Authors: Kashani Hooshang , Vora Manali V. , Kuraji Ryutaro , Fathi‐Kelly Hoorshad , Nguyen Trung , Tamraz Beniel , Tran Christine , Kapila Yvonne L. 
Published: March 2022

AbstractIntroductionRoot coverage procedures are not always predictable, and outcomes depend on several factors. This technique provides a predictable alternative to managing facial gingival recessions.Case SeriesA new grafting technique is introduced that requires no incisions at the recipient site, thereby preserving the integrity of the local blood supply to optimize the healing process. The graft is placed through the gingival sulcus via a molar or canine access (MOCA) approach, and there is minimal tension on the coronally advanced flap through use of suspension sutures. Thirteen non‐smoking patients, between the ages of 27 and 57, with Cairo RT1 facial recession were studied, with a follow‐up period of 1–60 weeks. This paper explains the step‐by‐step technique and highlights 13 cases.ConclusionComplete root coverage was achieved in all 13 cases, although one case showed initial altered healing. While MOCA is technique sensitive, it provides optimal root coverage results. With no incisions at the recipient site, there is no uneven texture or scar formation, and healing proceeds with minimal interruption.Why is this case series new information?

MOCA is a unique approach to introduce grafts into non‐incised sites of recession that can be one, two, or three teeth away at molars or canines.
Non‐incised approach minimizes interruption to blood supply.
Coronally advanced flaps are secured in place with composite‐fastened suspension sutures for tension‐free flap closure.
What are the keys to successful management of these cases?

Good quality and quantity of connective tissue graft
Early diagnosis and treatment of recession
Expert surgical technique
What are the key limitations to the success of these cases?

The quality of the donor site is variable among patients.
A technique‐sensitive approach
Advanced recession might warrant a second surgery.
Cytomorphologic features of thyroid nodules harboring thyroid adenoma‐associated fusion: A single institutional review of 11 cases
Authors: Roberts James W. , Lubin Daniel J. , Shi Qiuying , Viswanathan Kartik 
Published: March 2022

AbstractBackgroundThyroid adenoma‐associated (THADA) fusions are being identified more frequently with increased preoperative molecular testing on indeterminate thyroid fine‐needle aspirates (FNA). However, data on cytomorphologic features of THADA‐fusion thyroid lesions are limited. We examined cytomorphologic features of a THADA‐fusion thyroid FNA cohort with clinical, radiologic, and histologic data.MethodsOur THADA fusion FNA cohort included 11 specimens from 11 patients with a mean age and F:M ratio of 56.5 years and 2.7:1, respectively. Ten cases had FNA slides available for review and five cases had histopathology. Air‐dried Diff‐Quik and alcohol‐fixed Papanicolaou smears, and formalin‐fixed cell blocks were reviewed and findings were correlated with the matched resection, when available. Clinical and radiologic data were obtained from the medical record.ResultsTHADA fusion thyroid lesions were hypoechoic or isoechoic (80%), solid (80%) with well‐demarcated margins (100%) on ultrasound. Notable cytomorphologic features include crowded or prominent microfollicular groups (100%), scant colloid (91%), and mild nuclear atypia with nuclear grooves (100%), insignificant nuclear pleomorphism (100%), and without intranuclear pseudoinclusions (100%). All cases were classified as either atypia of undetermined significance (91%) or suspicious for follicular neoplasm (9%). Five resected cases were all low‐risk lesions (benign and malignant) with no evidence of recurrence in the limited available follow‐up.ConclusionTHADA‐fusion thyroid FNAs show a crowded or prominent microfollicular pattern with mild nuclear atypia and without intranuclear pseudoinclusions, which overlaps with the cytomorphology of other RAS‐like thyroid lesions. In our cohort, resected THADA lesions were low risk on histologic analysis.
Maternal deprivation affects goat kids’ social behavior before and after weaning
Authors: Toinon Claire , Waiblinger Susanne , Rault Jean‐Loup 
Published: March 2022

AbstractMaternal deprivation has been shown to disrupt the development of neonates. Nevertheless, separating the young animals from their dams soon after birth is a common practice in dairy farming. We investigated the effects of maternal deprivation on goat kids’ (Capra hircus) social behavior and social ontogeny before and after weaning. Twenty female kids were raised together with their dams (DR kids) and other lactating goats and kids, whereas 20 female kids were separated from their dams 3 days after birth and artificially reared together (AR kids). At weaning, each treatment group was split in half and moved into two new pens where they were mixed with the other treatment group. Social behaviors were recorded before and after weaning. Before weaning, AR kids were observed performing more play‐fighting, racing, stepping on each other, and standing in contact with each other than DR kids, but AR allogroomed less and spent less time resting alone than DR kids. After weaning and mixing of the treatments, DR kids initiated more and received less agonistic interactions than AR kids, but this difference reduced across the 5 weeks of observations as AR kids appeared to progressively change their social behavior after interacting with DR kids.
Extreme low‐flow effects on riverine fauna: A perspective on methodological assessments
Authors: White James C. , Aspin Thomas W. H. , Picken Jessica Louise , Ledger Mark E. , Wilby Robert L. , Wood Paul J. 
Published: March 2022

AbstractRiver flow regimes face increasing pressure from human activities including water resource management operations and climate change. Consequently, extreme hydrological events are becoming more severe and commonplace, and there is a pressing need to understand and manage their ecological effects. Extreme low flows (ELFs)—those displaying significantly greater magnitudes and durations than typical low‐flow conditions—are being increasingly experienced globally. Fish and macroinvertebrate responses to ELFs have been more widely researched relative to other organism groups in riverine environments, although such studies have employed variable methodological techniques. In this perspective piece, we identify field‐based assessments and controlled experiments as two key research paradigms used to examine riverine faunal responses to ELFs. Field‐based assessments are often explorative and can benefit from utilising large‐scale and long‐term datasets. Alternatively, controlled experiments typically employ more hypothesis‐driven approaches and can establish strong cause and effect linkages through high replication and control over potentially confounding parameters. Each paradigm clearly possesses their respective strengths, which we highlight and discuss how these could be better harnessed to optimise scientific advancements. To date, studies examining faunal responses to ELFs in these two research paradigms have largely been undertaken in parallel. Here, we argue that future research should seek to develop closer synergies to optimise the quality and quantity of evidence to better understand riverine faunal responses to ELFs. Such scientific advances are of paramount importance given the vulnerability of riverine fauna, and the ecosystems they comprise, to a new era of ELFs in many global regions.
Adsorption of ionomer and ionic liquid on model Pt catalysts for polymer electrolyte fuel cells
Authors: Kodama Kensaku , Motobayashi Kenta 
Published: March 2022

AbstractThe adsorption of the perfluoro‐sulfonic acid polymer of Nafion and ionic liquid (IL) of 1‐butyl‐3‐methylimidazolium bis(trifluoromethanesulfonyl)imide on the surface of Pt was investigated via voltammetric analyses, using stepped Pt single‐crystal electrodes with (111) terraces and (110) steps, and surface‐enhanced infrared absorption spectroscopy (SEIRAS) analyses using a Pt polycrystalline electrode. Sulfonate anion in Nafion was adsorbed on the stepped Pt single‐crystal electrodes and suppressed the oxygen reduction reaction (ORR) activity by more than 50%, regardless of the terrace width. The IL molecules were preferentially adsorbed on the step sites through a simple IL coating procedure. The SEIRAS analysis indicated that the IL molecules were stable on the Pt surface throughout potential cycles, where the anionic moieties were in contact with the Pt surface and reoriented depending on the potential. The IL modification prior to Nafion coating mitigated ionomer adsorption on the Pt surface. However, the mitigation effect was not reflected in the ORR activity because water production led to IL desorption during the ORR activity measurement. Accordingly, IL modification is a promising method for improving the performance of Pt catalysts in polymer electrolyte fuel cells; however, further studies to prevent the leaching of IL are required for practical applications of this approach.
Examining the consumer view of refreshing perception, relevant fruits, vegetables, soft drinks, and beers, and consumer age and gender segmentations
Authors: Ramirez Jessica L. , Hampton Amy , Du Xiaofen 
Published: March 2022

AbstractConsumer perspective of refreshing perception is underexplored, despite it being an emotional attribute to describe foods, beverages, hygiene products, and household items. An online survey (N = 1518) was designed to collect consumer insight into the importance of refreshing, the definition and factors related to it, and the identification of refreshing fruits, vegetables, and drinks. Nearly all participants (99.8%) cited that they have had the need to consume a food or beverage to feel refreshed, and 76.3% cited that they need this at least once per day. The factors most associated with refreshing were thirst‐quenching (84.1%), temperature (86.2%), and cooling taste (86.0%). Water (86.6%), watermelons (80.8%), and cucumbers (83.5%) were the beverages/foods most frequently specified as refreshing. A second survey (N = 1050) examined refreshing perception specifically related to beer consumption and associated flavor. Beer was rated highly refreshing by 75.5% of participants, affirming its refreshing reputation. Refreshing perceived from beer was most associated with cool temperature (95.4%), flavor of the beer (88.6%), lightened mood (87.1%), and thirst‐quenching (49.0%). Beers with crisp/clean flavors (87.3%) and citrus flavors (35.7%–51.7%) were most frequently specified as refreshing. There were no gender differences in the definition of refreshing and associated thirst‐quenching and cold, although age differences in defining beer refreshing were significant (p ≤ .05). There were significant gender and age differences in types of refreshing vegetables, soft drinks, beer flavors, and varieties. The study provided consumer insight into refreshing perception and the gained knowledge could be used in new product design.
Case study on an integrated interoperable metadata model for geoscience information resources
Authors: Han Sooyeon , Han JongGyu 
Published: March 2022

AbstractAn integrated metadata schema was created to promote interoperability and to characterize historically collected geoscience data. The metadata standard describes the steps taken to develop a switching‐across methodology that allows geoscience metadata standards (ISO 19115, CSDGM, ANZLIC and INSPIRE) to communicate with one another. We also demonstrated a real example of one of the switching‐across that was created. A representative metadata schema was created using items from harmonization standards that might be optimally mapped. Semantic interoperability allows users to access equivalent classes across several metadata standards in a uniform and consistent rule. It also tries to provide fundamental aspects that might characterize acquisition information to enhance data reuse and current metadata standards for data preservation and distribution.
Circulating microRNAs as predictive biomarkers of coronary artery diseases in type 2 diabetes patients
Authors: Mahjoob Golnoosh , Ahmadi Yasin , Fatima rajani Huda , khanbabaei Nafiseh , Abolhasani Sakhavat 
Published: March 2022

AbstractBackgroundType 2 diabetes mellitus (T2DM) is an increasing metabolic disorder mostly resulting from unhealthy lifestyles. T2DM patients are prone to develop heart conditions such as coronary artery disease (CAD) which is a major cause of death in the world. Most clinical symptoms emerge at the advanced stages of CAD; therefore, establishing new biomarkers detectable in the early stages of the disease is crucial to enhance the efficiency of treatment. Recently, a significant body of evidence has shown alteration in miRNA levels associate with dysregulated gene expression occurring in T2DM and CAD, highlighting significance of circulating miRNAs in early detection of CAD arising from T2DM. Therefore, it seems crucial to establish a link between the miRNAs prognosing value and development of CAD in T2DM.AimThis study provides an overview on the alterations of the circulatory miRNAs in T2DM and various CADs and consider the potentials of miRNAs as biomarkers prognosing CADs in T2DM patients.Materials and MethodsLiterature search was conducted for miRNAs involved in development of T2DM and CAD using the following key words: “miRNAs”, “Biomarker”, “Diabetes Mellitus Type 2 (T2DM)”, “coronary artery diseases (CAD)”. Articles written in the English language.ResultThere has been shown a rise in miR‐375, miR‐9, miR‐30a‐5p, miR‐150, miR‐9, miR‐29a, miR‐30d, miR‐34a, miR‐124a, miR‐146a, miR‐27a, and miR‐320a in T2DM; whereas, miR‐126, miR‐21, miR‐103, miR‐28‐3p, miR‐15a, miR‐145, miR‐375, miR‐223 have been shown to decrease. In addition to T2DM, some miRNAs such as mirR‐1, miR‐122, miR‐132, and miR‐133 play a part in development of subclinical aortic atherosclerosis associated with metabolic syndrome. Some miRNAs increase in both T2DM and CAD such as miR‐1, miR‐132, miR‐133, and miR‐373‐3‐p. More interestingly, some of these miRNAs such as miR‐92a elevate years before emerging CAD in T2DM.Conclusiondysregulation of miRNAs plays outstanding roles in development of T2DM and CAD. Also, elevation of some miRNAs such as miR‐92a in T2DM patients can efficiently prognose development of CAD in these patients, so these miRNAs can be used as biomarkers in this regard.
Correlation between dental enamel chemical composition and bracket debonding, comparing adhesive systems through a scanning electron microscope
Authors: Rodríguez‐Chávez Jacqueline Adelina , Arenas‐Alatorre Jesús Ángel , Flores‐Ruiz Hugo M. , Aguilar‐Pérez Fernando Javier , Flores‐Ledesma Abigailt , Moreno‐Vargas Yoshamin Abnoba , Pesqueira‐Melgarejo Roberto 
Published: March 2022

AbstractLiterature reports indicate that during bracket removal there can be enamel damage. We compare the shear bond strength (SBS) and tooth enamel loss of four adhesive systems and identify the Ca/P ratio. Then a total of 20 premolars were divided into four groups of five each. After prophylaxis, photographs were taken at 35× with a scanning electron microscope (SEM) and analyzed with X‐ray spectroscopy (EDS) at 250×. Brackets were bonded with Transbond™ MIP(G1), Transbond™ PLUS SEP(G2), Enlight(G3) and Stylus®(G4) adhesives, 24 h after were debonded with a Instron universal testing machine at 1 mm/min. All the brackets were photographed with the SEM. The amount of lost enamel was measured with AutoCad. All the results were measured with a significance level p < .05. The SBS general average at debonding was 7.94 ± 2.26 MPa, meanwhile the SBS for G1, G2, G3 and G4 was 9.38 ± 1.46, 6.28 ± 0.69, 9.08 ± 2.45 and 7.04 ± 2.64 MPa respectively. 90% of the samples had no enamel loss, 10% had enamel loss. Only two samples in G1 presented an enamel loss area of 0.34mm2 and 0.80mm2 respectively. From EDS analysis, the Ca/P ratio was 1.6 ± 0.05, 1.61 ± 0.03, 1.64 ± 0.83 and 1.59 ± 0.07 for G1, G2, G3 and G4 respectively; no statistically significant differences were found. We conclude that no association was found between the Ca/P ratio and enamel damage when brackets are removed.Highlights
Where enamel is lost, we observe fractures, steps, horizontal and vertical enamel loss.
There is a loss of tooth enamel from 0.34 to 0.80 mm2 with Transbond PLUS SEP.
Structural loss of enamel is almost inevitable during the separation of the bracket.
A national study of the mental health status of Asian international students in the United States
Authors: Xiong Yiying , Pillay Yegan 
Published: March 2022

AbstractThis study compared the mental health status of Asian international students (AIS) in the United States with American students and other international students by analyzing 4 years of data (2011–2014) from the American College Health Association‐National College Health Assessment. No significant differences were found in the ***AIS’ psychological distress, but their self‐reported self‐harm ideation and behavior were higher than the other two groups. Predictors of psychological distress were analyzed and implications for stakeholders are offered.
Artificial intelligence to detect abnormal heart rhythm from scanned electrocardiogram tracings
Authors: Bridge Joshua , Fu Lu , Lin Weidong , Xue Yumei , Lip Gregory Y. H. , Zheng Yalin 
Published: March 2022

AbstractBackgroundElectrocardiogram (ECG) interpretation is an integral part of the clinical ECG workflow; however, this process is often time‐consuming and labor‐intensive. We aim to develop a rapid, inexpensive means to detect abnormal ECGs using artificial intelligence (AI) from scanned ECG printouts.MethodsThe study included 1172 12‐lead ECG scans performed in 1172 individuals from a community in Guangzhou, China; 878 (74.9%) were diagnosed with sinus rhythm, and the remaining 294 (25.1%) with abnormal rhythms. A deep learning model consisting of a convolutional neural network based on InceptionV3 and a fully connected layer followed by a GEV activation was trained to classify scanned tracings as either normal or abnormal.ResultsIn a hold‐out testing set, the model achieved a area under curve (AUC), sensitivity, specificity, PPV, and NPV of 0.932 (95% confidence interval [CI]: 0.890, 0.976), 0.816 (95% CI: 0.657, 0.923), 0.993 (95% CI: 0.959, 1.0), 0.969 (95% CI: 0.838, 0.999), and 0.950 (95% CI: 0.90, 0.980) respectively, when using a probability threshold of 0.5. When compared with a physiological expert, these results show comparable performance with a statistically significant increase in specificity and a non‐significant decrease in sensitivity at the 95% level.ConclusionsWe have developed a rapid, inexpensive, accurate means to detect abnormal ECGs using AI. Easy and accurate identification of such “abnormal” ECGs could allow the mass automated review of ECGs in community settings where abnormal ones could be flagged using AI for detailed clinical review by healthcare professionals.
A prospective, randomized, single‐blind study comparing coblation and monopolar extracapsular tonsillectomy
Authors: Lou Zhengcai , Lou Zihan , Lv Tian , Chen Zhengnong 
Published: March 2022

AbstractObjectiveThe aim of this study was to compare intraoperative blood loss, postoperative pain, post‐tonsillectomy hemorrhage (PTH), and medical costs associated with extracapsular tonsillectomy between coblation and monopolar electrocautery in children.Materials and methodsThis study included 293 patients aged 6–15 years planned to undergo extracapsular tonsillectomy. Data on estimated blood loss, postoperative pain score, operation time, PTH, and the cost of disposable equipment were collected.ResultsCoblation extracapsular tonsillectomy was associated with significantly lower mean pain scores than monopolar technique on postoperative days 1 (p <.001) and 2 (p = 0.02). However, the pain score was similar between the groups at all other time points. The monopolar group had a significantly shorter operation time compared to the coblation group (11.09 ± 7.53 vs. 17.12 ± 4.29 min, p <.001). Intraoperative estimated blood loss was not significantly different between the groups (p = .43).The cost of extracapsular tonsillectomy was significantly lower in the monopolar compared to the coblation group (US$ 28.18 vs. US$ 430.48, p <.001). PTH occurred in 17 patients (5.80%) and required a second surgery. Secondary PTH occurred in 6.16% (9/146) and 0.68% (1/147) of patients in the coblation and monopolar groups, respectively (p <.001). The PTH was significantly higher in the tonsillitis compared to in the tonsillar hypertrophy (12.37% vs. 2.55%, p = .002), However, the difference of PTH was not significant among mean pain scores subgroups. Of the 17 patients with PTH, the lower pole, middle portion, and upper pole were involved in 15 (88.24%), 2 (11.76%), and 0 cases, respectively.ConclusionsCoblation and novel monopolar electrocautery extracapsular tonsillectomy are associated with similar postoperative pain scores except on postoperative days 1 and 2. However, monopolar technique offers significant advantages over coblation method with less operative time, decreased secondary PTH, and cost.Level of Evidence: NA.