bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and molecular characterization of Xeroderma pigmentosum in Moroccan population: a case series of 40 patients
Authors: Abbassi Meriame , Sayel Hanane , Senhaji Nadia , Trhanint Said , Bay Bay Hanane , Bouguenouch Laila , Mernisi Fatima Zahra 
Published: November 2022

Abstract
Background
Xeroderma pigmentosum (XP) is a rare autosomal recessive skin disorder characterized by hyperpigmentation, premature skin aging, ocular and cutaneous photosensitivity with increased risk of skin tumors. XP is caused by mutations in DNA repair genes that protect cells from UV-induced DNA damage. The current study aims to investigate, on clinical and genetic basis, Moroccan XP patients. We explored by direct sequencing the involvement of the prevalent XPA and XPC genes mutations: nonsense mutation (c.682C>T, p.Arg228X) and a two-base-pair (2 bp) deletion (c.1643 1644delTG or p.Val548Ala fsX25), respectively, in 40 index cases from 37 unrelated families in Moroccan population.

Results
Early skin and ocular manifestations were detected with high rate of malignancy. Cutaneous lesions progressed to malignant skin tumor in 70% of cases. Ocular tumors were also observed in 11 patients including BCC in eight cases, SCC in three cases and melanoma in four cases. Among the 40 patients, there were 20 homozygous cases for the 2 bp deletion in the XPC gene and 9 homozygous cases carrying the nonsense XPA mutation.

Conclusion
These findings obtained in the present study revealed that the XPC gene mutation (c.1643 1644delTG, p.Val548AlafsX25) is the major cause of Xeroderma pigmentosum in our population. The c.682C>T (p.Arg228X) mutation is relatively associated with moderate phenotype in XP group A Moroccan families. This result will also contribute to improving the molecular diagnosis of XP disease and will have a significant impact on improving the care of Moroccan patients and their relatives.
Reporting unit context data to stakeholders in long-term care: a practical approach
Authors: Cranley Lisa A. , Lo T K T , Weeks Lori E. , Hoben Matthias , Ginsburg Liane R. , Doupe Malcolm , Anderson Ruth A. , Wagg Adrian , Boström Anne-Marie , Estabrooks Carole A. , Norton Peter G. 
Published: November 2022

Abstract
Background
The importance of reporting research evidence to stakeholders in ways that balance complexity and usability is well-documented. However, guidance for how to accomplish this is less clear. We describe a method of developing and visualising dimension-specific scores for organisational context (context rank method). We explore perspectives of leaders in long-term care nursing homes (NHs) on two methods for reporting organisational context data: context rank method and our traditionally presented binary method—more/less favourable context.

Methods
We used a multimethod design. First, we used survey data from 4065 healthcare aides on 290 care units from 91 NHs to calculate quartiles for each of the 10 Alberta Context Tool (ACT) dimension scores, aggregated at the care unit level based on the overall sample distribution of these scores. This ordinal variable was then summed across ACT scores. Context rank scores were assessed for associations with outcomes for NH staff and for quality of care (healthcare aides’ instrumental and conceptual research use, job satisfaction, rushed care, care left undone) using regression analyses. Second, we used a qualitative descriptive approach to elicit NH leaders’ perspectives on whether the methods were understandable, meaningful, relevant, and useful. With 16 leaders, we conducted focus groups between December 2017 and June 2018: one in Nova Scotia, one in Prince Edward Island, and one in Ontario, Canada. Data were analysed using content analysis.

Results
Composite scores generated using the context rank method had positive associations with healthcare aides’ instrumental research use (p < .0067) and conceptual research use and job satisfaction (p < .0001). Associations were negative between context rank summary scores and rushed care and care left undone (p < .0001). Overall, leaders indicated that data presented by both methods had value. They liked the binary method as a starting point but appreciated the greater level of detail in the context rank method.

Conclusions
We recommend careful selection of either the binary or context rank method based on purpose and audience. If a simple, high-level overview is the goal, the binary method has value. If improvement is the goal, the context rank method will give leaders more actionable details.
Machine learning for prediction of wind effects on behavior of a historic truss bridge
Authors: Wang Jun , Kim Yail J. , Kimes Lexi 
Published: November 2022

AbstractThis paper presents the behavior of a 102-year-old truss bridge under wind loading. To examine the wind-related responses of the historical bridge, state-of-the-art and traditional modeling methodologies are employed: a machine learning approach called random forest and three-dimensional finite element analysis. Upon training and validating these modeling methods using experimental data collected from the field, member-level forces and stresses are predicted in tandem with wind speeds inferred by Weibull distributions. The intensities of the in-situ wind are dominated by the location of sampling, and the degree of partial fixities at the supports of the truss system is found to be insignificant. Compared with quadrantal pressure distributions, uniform pressure distributions better represent the characteristics of wind-induced loadings. The magnitude of stress in the truss members is enveloped by the stress range in line with the occurrence probabilities of the characterized wind speed between 40% and 60%. The uneven wind distributions cause asymmetric displacements at the supports.
Effect of the COVID-19 Pandemic on Place of Death Among Medicaid and Commercially Insured Patients With Cancer in Washington State
Authors: Panattoni Laura E. , McDermott Cara L. , Li Li , Sun Qin , Fedorenko Catherine R. , Sanchez Hayley A. , Kreizenbeck Karma L. , Shankaran Veena , Ramsey Scott D. 
Published: November 2022

PURPOSE The COVID-19 pandemic–related disruptions in health care delivery might have affected end-of-life care in patients with cancer. We examined changes in place of death and hospice support for Medicaid and commercially insured patients during the pandemic. PATIENTS AND METHODS We linked Washington State cancer registry records with claims from Medicaid and two commercial insurers for patients with solid tumor age 18-64 years. The study included 322 Medicaid and 162 commercial patients who died between March 2017 and June 2019 (pre–COVID-19), along with 90 Medicaid and 47 commercial patients who died between March and June 2020 (COVID-19). Place of death was categorized as hospital, hospice (home or nonhospital facility), and home without hospice. Place of death was compared using adjusted multinomial logistic regressions stratified by payer and time period (pre–COVID-19 v COVID-19). The clinical and sociodemographic factors associated with dying at home without hospice were examined, and adjusted marginal effects (ME) are reported. RESULTS In the adjusted pre–COVID-19 analysis, Medicaid patients were more likely than commercially insured patients to die in hospital (48% v 36%; adjusted ME, 11%; P = .02). In the pre–COVID-19/COVID-19 analysis, Medicaid patients' place of death shifted from hospital (48% v 32%; ME, −16%; P < .01) to home without hospice (19.9% v 38.0%; ME, 16.5%; P < .01). However, there were no statistically significant changes pre–COVID-19/COVID-19 for commercial patients. As a result, during COVID-19, Medicaid patients were more likely than commercial patients to die at home without hospice (38% v 22%; ME, 16%; P = .04) as were male versus female patients (ME, 16%; P < .01). CONCLUSION The pandemic might have disproportionately worsened the end-of-life experience for Medicaid enrollees with cancer. Attention should be paid to societal and health system factors that decrease access to care for Medicaid patients.
Utility of Multimodality Approach Including Systemic FGF23 Venous Sampling in Localizing Phosphaturic Mesenchymal Tumors
Authors: Kato Hajime , Koga Minae , Kinoshita Yuka , Hidaka Naoko , Hoshino Yoshitomo , Takashi Yuichi , Arai Makoto , Kobayashi Hiroshi , Katsura Masaki , Nakamoto Yuji , Makise Naohiro , Ushiku Tetsuo , Hoshi Kazuto , Nangaku Masaomi , Makita Noriko , Fukumoto Seiji , Ito Nobuaki 
Published: November 2022

Abstract

Context
Tumor-induced osteomalacia (TIO) is one of the most common forms of acquired fibroblast growth factor 23 (FGF23)-related hypophosphatemia and is usually caused by phosphaturic mesenchymal tumors (PMTs). Although the complete resection of PMTs can cure TIO, preoperative localization of tumors by standard imaging modalities is often challenging. In addition to 18F-fluoro-2-deoxy-D-glucose positron emission tomography–computed tomography (FDG-PET) and 111In-pentetreotide scintigraphy (SRS), systemic FGF23 venous sampling (FGF23VS) has been used to help localize PMTs in specialized institutions.

Objective
This study aimed to evaluate the diagnostic performance of each imaging test and their combinations in localizing PMTs.

Methods
In an observational retrospective study of patients with adult-onset FGF23-related osteomalacia who underwent all 3 imaging studies (FDG-PET, SRS, and FGF23VS), the rate of successful preoperative localization of the tumors was evaluated only in the patients with pathological diagnoses of PMTs, considering the possibility that pathogenesis of patients without identified tumors might be due to other causes such as late-onset hereditary FGF23-related hypophosphatemia.

Results
A total of 30 Japanese patients with TIO (median age, 60 years [range, 28-87 years]; 10 women [33.3%]) were included in the study. The success rate of preoperative localization for each test and combinations of 2 or 3 tests among 18 patients with PMTs was as follows: 72% (FDG-PET), 72% (SRS), 94% (FGF23VS), 89% (FDG-PET, SRS), 100% (FDG-PET, FGF23VS), 94% (SRS, FGF23VS), and 100% (FDG-PET, SRS, and FGF23VS).

Conclusion
We observed the highest localization rate of PMTs in patients with identified PMTs with the combination of FDG-PET and FGF23VS.
Influence of different treatment methods of Left Colic Artery on postoperative rehabilitation of patients undergoing Laparoscopic Radical Resection of Rectal Cancer
Authors: Ding Chuang , Kong Lingyong , Zhang Ming , Chen Yan 
Published: November 2022

Objective: To investigate the effect of different treatment methods of the left colic artery (LCA) on postoperative rehabilitation of patients undergoing laparoscopic radical resection of rectal cancer.
Methods: Retrospective analysis was performed on 70 patients undergoing laparoscopic radical resection of rectal cancer who were admitted to The Affiliated Suqian Hospital of Xuzhou Medical University from January, 2020 to December, 2022 were selected and divided into two groups according to different treatment methods of LCA. The preservation group (LCA group) (n=34 cases) and the non-preservation group (NLCA group) (n=36 cases). Both groups were treated with laparoscopic radical resection of rectal cancer. IMA was preserved in the LCA group, but not in the NLCA group. The efficacy indicators, surgical treatment and rehabilitation-related indicators, gastrointestinal hormone indicators (motilin (MTL), gastrin (GAS)), and postoperative complications risk were compared between the two groups before and after surgery.
Results: No statistically significant difference was observed between the two groups in terms of efficacy indicators (total number of lymph nodes dissected and number of lymph nodes at the root of the IMA), operation time, intraoperative blood loss, and postoperative drainage tube placement time (p>0.05). However, postoperative anal flatus and hospital stay in the LCA group were considerably shorter than those in the NLCA group (p<0.05). Postoperatively, the levels of MTL and GAS in the two groups were significantly decreased, and the LCA group decreased slightly compared with the NLCA group (p<0.05). Moreover, the incidence of complications in the LCA group (5.88%) was significantly lower than that in the NLCA group (27.78%) (p<0.05).
Conclusion: Preservation of LCA and no-preservation of LCA in laparoscopic radical resection of rectal cancer are comparable in terms of therapeutic effect, and the surgery with preservation of LCA is worthy of clinical promotion due to its various benefits such as less impact on gastrointestinal hormone indicators, lower risk of complications, and faster postoperative recovery.
doi: https://doi.org/10.12669/pjms.39.1.6366
How to cite this: Ding C, Kong L, Zhang M, Chen Y. Influence of different treatment methods of Left Colic Artery on postoperative rehabilitation of patients undergoing Laparoscopic Radical Resection of Rectal Cancer. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.6366
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Inglämnlagare - a tool for restructuring Swedish site data for statistical analysis
Authors: Löwenborg Daniel , Antomonov Filipp 
Published: November 2022

Background: This paper presents a new software tool, Inglämnlagare, developed to be open-source, that restructures information about ancient remains in Sweden for analysis. The background is a new version of the ancient sites database, the Historic Environment Record, curated by the Swedish National Heritage Board, that was launched in 2018 with a new database model that structures the information differently compared to previous versions. Methods: The program, written in Python programming language, has multicore support in order to improve performance for large files and uses regular expressions to extract information about individual features of composite sites. Such features, together with their summed amount, are written as new individual fields to a comma-separated value file. The program is delivered as a source script file that can be executed in any Python environment. Use cases: As an example of use, a case study of exploring graves of rectangular shape found within Sweden is provided. The use case also describes the different steps involved in preparing the data in QGIS to run the program, as well as some methods to efficiently analyse and visualize the output. Conclusions: Inglämnlagare will make more information from the Swedish record of ancient sites accessible for research and can be used to explore different content of the record more efficiently than previously possible. While the tool is written specifically for this dataset it also provides an example of how open-source tools can be used for data wrangling making information designed for a specific purpose, such as online dissemination, appropriate for analysis.
Evaluation of clinical, histology, TNF-α, and collagen expressions on oral ulcer in rats after treatment with areca nut and chrysanthemum oral gel
Authors: Meutia Sari Liza , Mubarak Zaki , Keumala Sari Dina 
Published: November 2022

Background: Areca nut (Areca catechu Linn.) is the seed of the fruit of the oriental palm that is commonly used among Southeast Asian communities. Chrysanthemum (Dendrathema grandiflora) is a flowering plant originating from East Asia and dominantly grows in China. Both of these plants have strong antioxidant activities. To investigate the mechanism of their wound healing activities, we prepared areca nut and chrysanthemum polyethylene oral gel and performed several in vivo assays using Sprague–Dawley rats. Methods: Sprague–Dawley rats were divided into six groups: Negative control group (rats with base gel treatment), positive control group (rats treated with triamcinolone acetonide), F1 (treatment with 20% areca nut:80% chrysanthemum), F2 (treatment with 50% areca nut:50% chrysanthemum), F3 (treatment with 80% areca nut:20% chrysanthemum), and normal group (without ulcer and treatment). Traumatic ulcers were performed on the buccal mucosa of all experimental animals that received topical oral gel and triamcinolone acetonide twice a day for seven days. The clinical and histological characteristics were analyzed and scored. Results: During the six days, the ulcerated area receded linearly over time and was completely cicatrized in F2, F3, and the positive control group (Dependent t-test, p<0.05). There were significant increases in body weight in F2 and positive control groups. There were no significant differences between groups in histology examination (Kruskal Wallis test, p<0.05). The moderate score of TNF-α levels was seen in F2 and positive control groups (ANOVA/Tukey test, p<0.05). In the collagenases assay, a high concentration of areca nut (F3) induced the abundance of collagen during the ulcer healing process. Conclusions: The combination of areca nut and chrysanthemum extract in the oral gel can optimize the healing of traumatic oral ulcers in Sprague-Dawley rats through the increase of TNF-α and collagen deposition.
A short-term prospective study to evaluate the clinical performance of endosseous zirconia implants
Authors: Hegde Rakshith , Dubey Mridu , Shetty Manoj 
Published: November 2022

Background: Endosseous zirconia implants have been established as an alternative to conventional titanium implants, especially in the aesthetic zone. This pilot study aimed to evaluate the outcome of rehabilitation with zirconia implants, in a subset of the Indian population, involving varying clinical scenarios. Methods: A total of 10 one-piece zirconia implants were placed in seven patients requiring rehabilitation of missing teeth. The survival rate and marginal bone levels were evaluated at six months and 12 months following implant placement. Results: Five implants were placed in the maxilla and five in the mandible, including well-healed sites, extraction sockets, a single cantilever in the lower anterior region, and a full-arch rehabilitation. During the observation period, two early implant failures were noted resulting in a survival rate of 80%. Mean marginal bone loss of 0.73mm was seen one year following implant placement, with maximum bone loss occurring in the first six months. Conclusion: The results of this study encourage the use of endosseous zirconia implants in diverse clinical scenarios with careful case selection. However, long-term studies are needed to further validate these findings.
The “Rotten” matter in A Farewell to Arms: An Ecological Gothic reading
Authors: Ng Lay Sion 
Published: November 2022

This article uncovers the gothic tropes manifest in the “rotten” food, human bodies, landscapes, and rain in Ernest Hemingway’s A Farewell to Arms through an eco-gothic perspective. It demonstrates how the rotten food, the disjointed bodies, the broken landscapes, and the gothic rain can be viewed in the novel as counter-narratives against the narratives of war, the military, and modern medicine. The first part of this article suggests interpreting war as a form of cannibalism by exploring the representations of rotten food and the connection between eating and killing. Next, the author focuses on how the body is fragmented both metaphorically and literally by the discourse of war, the military, and medical science. The third part uncovers the non-anthropocentric consciousness embedded within the protagonist’s narrative, followed by the gothicizing and romanticization of nature in the fourth section. Here, the protagonist’s linking of the human body to the natural landscape, the descriptions of the gothic rain, and the romanticized snow—all these, as the author argues, can be interpreted as a collective resistance against industrial, anthropocentric warfare.
The influence of magnesium preparations on the change in metabolism in the modeling of toxic nephropathy in animals
Authors: Pavliuk N. , Badiuk N. 
Published: November 2022

In an experiment on 39 white Wistar rats of autobred breeding, the authors modeled toxic nephropathy and assessed the possibility of correcting damage using magnesium-containing preparations - 5% Bischofite solution and «Donat Mg». The work was carried out in accordance with the regulatory documents of the European Union and Ukraine.
The results of the studies showed that in addition to damage to the structure of the kidneys: wrinkling of capillary glomeruli, expansion of the Bowman space, destruction of part of the convoluted tubules; there is a violation of metabolic processes in the form of: an increase in the total blood protein, a redistribution of the proportion of different proteins in its composition, a decrease and imbalance of ATPases; increase in fasting amount of glucose; activation of lipid peroxidation and inactivation of AOD (catalase); decrease in magnesium levels in the blood. The use of magnesium-containing preparations by animals - a 5% solution of bischofite or «Donat Mg» had a unidirectional positive effect on the condition of the experimental animals. The structure of the kidneys improved, because. there were fewer wrinkled glomeruli, there were no lymphocytes between the capillaries, visually less damaged tubules were recorded; the interstitial layers did not differ from the norm; in terms of metabolism, there was a closeness of the total protein and the nomenclature of its components to the control, less changes in the activity of ATPases; LPO/AOZ systems; changes in fasting glucose, similarity of Mg+2 content to control data.
The authors believe that the intake of exogenous Mg+2 has a positive effect on the state of redox processes in the cells of the body, which helps to maintain the body's resistance at a higher level and prevents severe kidney damage.
Celiac disease - a review on recent advances in characteristics, diagnostic and treatments
Authors: Artykiewicz Klaudia , Czarkowski Marcin , Gorczyca Kamila , Grodkiewicz Maria , Kozieł Paweł , Krzysiek Urszula , Podgórska Klaudia , Puła Aleksandra , Słupczyńska Aleksandra , Urbaś Weronika 
Published: November 2022

Introduction and purpose:
Celiac disease occurs in 1% of the general population. However, many cases remain unrecognized.
The disease is a chronic immune-mediated disorder triggered by the ingestion of gluten that appears in individuals with genetic susceptibility. Celiac disease can develop in paediatric patients as well as adults.
The purpose of this review is to analyze the newest information on the characteristics, diagnosis and treatment of patients with celiac disease.
Material and methods:
This review was based on available data collected in the PubMed database and published between 2015 and 2022. The research was done by looking through keywords such as: “celiac disease”, “Gluten-Free Diet”, “diagnosis” and “treatment”.
Results:
The diagnosis of celiac disease is most often delayed due to the broad spectrum of presentations. Screening of at-risk individuals is important to progress the diagnosis.
It is additionally crucial to raise clinicians' attention to non-specific parenteral symptoms that may indicate celiac disease. The majority of the symptoms arise from nutritional deficiencies caused by intestinal malabsorption. According to scientific reports, the most common deficiencies of people with celiac disease are iron, folic acid, vitamin B12, fat-soluble vitamins and a calcium.
Conclusions:
Recent years have seen the emergence of research into new therapeutic options, but their efficacy and safety still need to be evaluated more thoroughly. Strict adherence to a gluten-free diet by patients is still the only treatment option at present.
Celiac disease, due to the constant increase in knowledge about its pathogenesis, diagnosis and treatment is an important material for further research.