bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dialysis Care for US Military Veterans in Puerto Rico during the 2017 Atlantic Hurricane Season
Authors: Lukowsky Lilia R. , Dobalian Aram , Kalantar-Zadeh Kamyar , Der-Martirosian Claudia 
Published: May 2022

Abstract

Objectives:
Patients with end stage kidney disease (ESKD) are at higher risk for increased mortality and morbidity due to disaster-related disruptions to care. We examine effects of Hurricanes Irma and Maria on access to dialysis care for US Department of Veterans Affairs (VA) ESKD patients in Puerto Rico.

Methods:
A retrospective, longitudinal cohort study was conducted among VA patients with at least 1 dialysis-related encounter between September 6, 2016, and September 5, 2018. The annual number of dialysis encounters, visits to an emergency department (ED), and the number of deaths pre- and post-hurricanes were compared. A random effects logistic regression model for correlated binary outcomes was fitted for predictors of mortality. Chi-square tests were for differences between pre- and post-hurricane visits.

Results:
The number of ED visits increased in post-hurricane period (1172 [5.7%] to 1195 [6.6%]; P < 0.001). ESKD-related ED visits increased from 200 (0.9%) to 227 (1.3%) (P < 0.05). Increase in mortality was associated with age (OR = 1.66; CI: 1.23-2.17), heart failure (OR = 2.07; CI: 1.26-3.40), chronic pulmonary disease (OR = 3.26; CI: 1.28-8.28), and sepsis (OR = 3.16; CI: 1.89-5.29).

Conclusions:
There was an increase in dialysis services at the San Juan VA Medical Center post-Irma/Maria, and access to dialysis care at the non-VA clinics was limited. The role of VA dialysis centers in providing care during disasters warrants further investigation.
The incidence of significant pathology in patients presenting with benign-appearing unilateral nasal polyps
Authors: Edafe O , Weight G , Morsy M , Mirza S 
Published: May 2022

AbstractObjectiveThe presentation of unilateral nasal polyps traditionally necessitates histological evaluation for a neoplasm. This study sought to determine the rates of significant pathology in patients presenting with benign-appearing unilateral nasal polyps, to inform practice.MethodAll patients who underwent nasal polypectomy for benign-appearing unilateral nasal polyps over a 13-year period were included.ResultsA total of 77 patients were included. On histology, 60 cases (77.9 per cent) were found to be inflammatory polyps. Thirteen cases were neoplastic, of which 11 (14.3 per cent) were benign and 2 (2.6 per cent) were malignant neoplasms. The following significant pathologies were found: Schneiderian papillomas, in 10 cases (13.0 per cent); neurofibroma, in 1 case (1.3 per cent); adenoid cystic carcinoma, in 1 case (1.3 per cent); and malignant melanoma, in 1 case (1.3 per cent).ConclusionOur data support routine histological assessment for all unilateral nasal polyps. Malignancy is rare (2.6 per cent) in patients presenting with benign-appearing unilateral nasal polyps. In elderly, unfit patients with minimal symptoms, initial conservative management may be reasonable.
A lifespan perspective on depression in the postpartum period in a racially and socioeconomically diverse sample of young mothers
Authors: Hipwell Alison E. , Tung Irene , Krafty Robert T. , Leong Audrey W. , Spada Meredith , Vaccaro Hope , Homitsky Sarah C. , Moses-Kolko Eydie , Keenan Kate 
Published: May 2022

AbstractBackgroundConsistent evidence from retrospective reports and case registry studies indicates that a history of depression is a major risk factor for depression in the peripartum period. However, longitudinal studies with racially and socioeconomically diverse samples of young mothers are lacking, and little is known about developmental patterns of depression across the lifespan that can inform preventive interventions.MethodsYoung primiparous mothers (n = 399, 13–25 years, 81% Black) were recruited from a population-based prospective study that began in childhood. Women reported on depression symptoms for at least 3 years prior to their pregnancy, during pregnancy, and at 4 months postpartum. Linear regression models were used to estimate change in pre-pregnancy depression severity and to evaluate associations between patterns of lifetime history and postpartum depression symptoms.ResultsResults revealed high levels of continuity in depression from pregnancy to postpartum, and across multiple years pre-pregnancy to postpartum. Overall, depression severity leading up to pregnancy decreased over time, but patterns of worsening or improving symptoms were not associated with depression severity in the postpartum period. Instead, area under the pre-pregnancy trajectory curve, representing cumulative lifetime depression burden, was uniquely associated with postpartum depression after adjusting for prenatal depression severity.ConclusionsDepression in the postpartum period should be considered within a lifespan perspective of risk that accumulates before conception. Clinical screening and early interventions are needed in adolescence and young adulthood to prevent the onset and persistence of depressive symptoms that could have long-term implications for peripartum health.
Caring trajectories and health in mid-life
Authors: Evandrou Maria , Falkingham Jane , Gómez-León Madelin , Vlachantoni Athina 
Published: May 2022

AbstractPrevious research has found varied effects of informal care provision on the carer's health status. Few studies have, however, examined this relationship dynamically. This paper is the first to analyse trajectories of care among men and women in mid-life and their impact on health outcomes using a nationally representative prospective cohort study. Data from three waves of the United Kingdom (UK) National Child Development Study (N = 7,465), when the respondents were aged 46, 50 and 55, are used to derive care trajectories capturing the dynamics of care provision and its intensity. Logistic regression investigates the impact of caring between the ages of 46 and 55 on the carers' report of depression and poor health at age 55. At age 46, 9 per cent of men and 16 per cent of women provided some level of informal care; rising to 60 per cent for both genders at ages 50 and 55. Just 7 per cent of women and 4 per cent of men provided care at all observation points, with the most common trajectory being ‘starting to care’ at ages 50 or 55. New carers experienced a lower risk of depression at age 55, reflecting that they may not have experienced the caring role long enough to have an adverse impact on their wellbeing. The findings highlight that the majority of individuals with surviving parents experience caring at some point during mid-life, underlining the need for further longitudinal research to better understand the complex relationships between care-giving and health for different groups of cares.
Precision comparison of two 3-DoF translational parallel manipulators based on the orientation errors due to joint clearances
Authors: Chouaibi Y. , Chebbi A.H. , Affi Z. , Romdhane L. 
Published: May 2022

AbstractThis paper presents a comparative study of two translational parallel manipulators (TPMs) with three Degrees of Freedom (3-DOF) based on the orientation errors due to joint clearances. In fact, the kinematic and static models of the manipulators have been used to determine the analytical model of the orientation errors. Then, the maximum and the sensitivity of the orientation errors have been considered as criteria to compare the precision of the DELTA and the RAF manipulators. The maximum orientation error is determined by solving an optimization problem of the previous analytical model. The sensitivity of the orientation errors is divided into two types: one related to the sensitivity of the orientation errors to the geometric parameters and another one related to the sensitivity of the orientation error to the joint clearances. The results show that the RAF robot precision is more sensitive to the joint clearances than the DELTA one. However, this advantage of the DELTA is limited to a portion of the workspace, which is free from singular configurations.
Environnement résidentiel et vieillissement en santé : le rôle de l’activité physique et de la participation sociale
Authors: Patte Marion , Chaix Basile , Gerber Philippe , Klein Olivier , Perchoux Camille , Vallée Julie 
Published: May 2022

RésuméLe vieillissement démographique est un des défis majeurs du 21e siècle. Il pose directement la question du « vieillissement en santé », un processus aidant les personnes âgées à rester en bonne santé et indépendantes le plus longtemps possible. L’influence des facteurs environnementaux sur ce processus peut varier selon les individus et leurs comportements. L’enchevêtrement de ces facteurs représente un défi autant théorique que méthodologique. Cet article a pour objectifs i) de quantifier les associations entre l’environnement physique et social du quartier des personnes âgées et leur vieillissement en santé et ii) d’examiner si leur activité physique et leur participation sociale jouent un rôle de médiation dans ces associations. Si certaines caractéristiques du quartier relatives à la réputation, l’accès aux services, et la cohésion sociale sont associées au vieillissement en santé, il existe un soutien limité à l’idée que les comportements tiennent un rôle d’intermédiaire dans cette relation.
The Role of Freshwater Forcing on Surface Predictability in the Gulf of Mexico
Authors: Sun Daoxun , Bracco Annalisa , Liu Guangpeng 
Published: May 2022

AbstractThe potential predictability of fields at the ocean surface in the northern Gulf of Mexico (GoM) is investigated through five ensembles of regional ocean simulations between 2014 and 2016. The ensembles explore two horizontal resolutions and different representations of the riverine inflow, and focus on the interactions between the Loop Current system (LCS) and the riverine system. The potential predictability of the surface fields is high when simulated by an ocean‐only model forced by appropriate atmospheric forcing and boundary conditions, and the ensembles simulate similar LCS behavior up to 5 months. The ensemble spread provides a mean to quantify the potential predictability. The ensembles confirm that LCS‐riverine interactions are modulated by the LC mesoscale variability. The relationship is two‐ways, with the LCS being influenced by—And not only influencing—The freshwater plume. Whenever the freshwater flux is strong, the northward extension of the LCS is constrained by the intensified salinity fronts. This influence is slightly stronger if the riverine inflow is simulated in an active fashion with a meridional velocity component proportional to the flux. Sea surface temperature (SST) and salinity (SSS) predictability have opposite seasonality in their signal, with the SST (SSS) being more predictable in summer (winter). Partially resolving submesoscale instabilities and improving the realism of the riverine fluxes’ representation causes the spread to increase, especially in SST. When increasing resolution, the spread increases also for surface vorticity due to feedbacks between the mesoscale and submesoscale circulations. The intraseasonal and interannual signal in vorticity is however similar among ensembles.
Effects of Cloud Microphysics on the Universal Performance of Neural Network Radiation Scheme
Authors: Song Hwan‐Jin , Kim Park Sa 
Published: May 2022

AbstractUnderstanding the effect of cloud microphysical changes on the stability of radiation emulator is essential in an operational weather forecasting model with frequent updates. This study examined the effect of 15 microphysics schemes on a radiation emulator for real and ideal cases. In the real case, although the forecast errors against the control run increased with varying microphysics schemes to the trained scheme, the forecast error of 2‐m temperature was rather improved by 0.9%–5.4% when compared with observations. The radiation emulator for the real case was applied to an ideal squall‐line simulation to test its universal application, resulting in increase of 8.6%–41.3% more forecast errors in heating rates and fluxes for 14 microphysics schemes more than the trained scheme. These errors could be reduced by 26.5%–50.4% with the use of a compound parameterization. Therefore, the stability and accuracy of radiation emulator on microphysics changes was confirmed.
Hydroacoustic Travel Time Variations as a Proxy for Passive Deep‐Ocean Thermometry—A Cookbook
Authors: Smets P. S. M. , Weemstra C. , Evers L. G. 
Published: May 2022

AbstractWe report on the extraction of deep ocean travel time variations from time‐lapse cross‐correlations between a hydrophone station and a three‐component broadband seismometer. The signals we cross‐correlate in this study result from repeated activity by the Monowai seamount, one of the most active submarine volcanoes of the Tonga‐Kermadec ridge. In particular, we introduce a specific workflow to exploit repetitive hydroacoustic underwater source activity, which we detail to such an extent that it serves as an example (or “cookbook”). For this reason, we have made the source code publicly available. The workflow proposed in this study (a) overcomes differences in instrument sensitivity and sample rates, (b) involves the selection of eligible cross‐correlations based on a source activity criterium as well as slowness analysis, and (c) extracts the travel time variations in distinct frequency bands. In our case, the two frequency bands are 3–6 and 6–12 Hz. We find that the estimated travel time variations in both frequency bands consist of a complex periodic pattern superimposed on a robust linear trend. This linear trend is decreasing, which we attribute to increasing water temperatures along the propagation path of the hydroacoustic signals.
Stage IV colon cancer patients without DENND2D expression benefit more from neoadjuvant chemotherapy
Authors: Ma Wen-juan , Chen Yukun , Peng Jian-hong , Tang Chaoming , Zhang Ling , Liu Min , Hu Shanshan , Xu Haineng , Tan Hua , Gu Yangkui , Pan Zhi-zhong , Chen Gong , Zhou Zhong-guo , Zhang Rong-xin 
Published: May 2022

AbstractAccording to the EPOC study, chemotherapy could improve 5-year disease-free survival of stage IV colon cancer patients by 8.1%. However, more molecular biomarkers are required to identify patients who need neoadjuvant chemotherapy. DENND2D expression was evaluated by immunohistochemistry in 181 stage IV colon cancer patients. The prognosis was better for patients with DENND2D expression than patients without DENND2D expression (5-year overall survival [OS]: 42% vs. 12%, p = 0.038; 5-year disease-free survival: 20% vs. 10%, p = 0.001). Subgroup analysis of the DENND2D-negative group showed that patients treated with neoadjuvant chemotherapy achieved longer OS than patients without neoadjuvant chemotherapy (RR = 0.179; 95% CI = 0.054–0.598; p = 0.003). DENND2D suppressed CRC proliferation in vitro and in vivo. Downregulation of DENND2D also promoted metastasis to distant organs in vivo. Mechanistically, DENND2D suppressed the MAPK pathway in CRC. Colon cancer patients who were DENND2D negative always showed a worse prognosis and were more likely to benefit from neoadjuvant chemotherapy. DENND2D may be a new prognostic factor and a predictor of the need for neoadjuvant chemotherapy in stage IV colon cancer.
Neurotransmitter phenotype switching by spinal excitatory interneurons regulates locomotor recovery after spinal cord injury
Authors: Bertels Hannah , Vicente-Ortiz Guillem , El Kanbi Khadija , Takeoka Aya 
Published: May 2022

AbstractSevere spinal cord injury in adults leads to irreversible paralysis below the lesion. However, adult rodents that received a complete thoracic lesion just after birth demonstrate proficient hindlimb locomotion without input from the brain. How the spinal cord achieves such striking plasticity remains unknown. In this study, we found that adult spinal cord injury prompts neurotransmitter switching of spatially defined excitatory interneurons to an inhibitory phenotype, promoting inhibition at synapses contacting motor neurons. In contrast, neonatal spinal cord injury maintains the excitatory phenotype of glutamatergic interneurons and causes synaptic sprouting to facilitate excitation. Furthermore, genetic manipulation to mimic the inhibitory phenotype observed in excitatory interneurons after adult spinal cord injury abrogates autonomous locomotor functionality in neonatally injured mice. In comparison, attenuating this inhibitory phenotype improves locomotor capacity after adult injury. Together, these data demonstrate that neurotransmitter phenotype of defined excitatory interneurons steers locomotor recovery after spinal cord injury.
PlantMWpIDB: a database for the molecular weight and isoelectric points of the plant proteomes
Authors: Mohanta Tapan Kumar , Kamran Muhammad Shahzad , Omar Muhammad , Anwar Waheed , Choi Gyu Sang 
Published: May 2022

AbstractThe molecular weight and isoelectric point of the proteins are very important parameters that control their subcellular localization and subsequent function. Although the genome sequence data of the plant kingdom improved enormously, the proteomic details have been poorly elaborated. Therefore, we have calculated the molecular weight and isoelectric point of the plant proteins and reported them in this database. A database, PlantMWpIDB, containing protein data from 342 plant proteomes was created to provide information on plant proteomes for hypothesis formulation in basic research and for biotechnological applications. The Molecular weight and isoelectric point (pI) are important molecular parameters of proteins that are useful when conducting protein studies involving 2D gel electrophoresis, liquid chromatography-mass spectrometry, and X-ray protein crystallography. PlantMWpIDB provides an easy-to-use and efficient interface for search options and generates a summary of basic protein parameters. The database represents a virtual 2D proteome map of plants, and the molecular weight and pI of a protein can be obtained by searching on the name of a protein, a keyword, or by a list of accession numbers. The PlantMWpIDB database also allows one to query protein sequences. The database can be found in the following link https://plantmwpidb.com/. The individual 2D virtual proteome map of the plant kingdom will enable us to understand the proteome diversity between different species. Further, the molecular weight and isoelectric point of individual proteins can enable us to understand their functional significance in different species.
Application of direct peptide reactivity assay for assessing the skin sensitization potential of essential oils
Authors: Omeragic Elma , Dedic Mirza , Elezovic Alisa , Becic Ervina , Imamovic Belma , Kladar Nebojsa , Niksic Haris 
Published: May 2022

AbstractPlant-derived products are frequently found as ingredients in cosmetics. However, the current data show non-neglectable skin sensitizing potential of these preparations suggesting an urgent need for data regarding their health safety profile. The aim of this study was to assess the skin sensitization potential of commercial essential oils by selected Lamiaceae species (Lavandula angustifolia, Melissa officinalis, Mentha longifolia, Thymus vulgaris, Salvia officinalis, and Rosmarinus officinalis) using a chemistry-based Direct Peptide Reactivity Assay (DPRA) in order to predict their potential allergic properties. In the DPRA assay, nucleophile-containing synthetic peptides (cysteine peptide and lysine peptide) were incubated with the test substance for 24 h. Depletion of the peptide in the reaction mixture was measured by high-pressure liquid chromatography (HPLC) using UV detection and the average peptide depletion data for cysteine and lysine was then calculated. Menthae longifoliae aetheroleum showed no or minimal reactivity with 4.48% cysteine depletion, Rosmarini aetheroleum and Salviae aetheroleum showed low reactivity with the 12.79% and 15.34% of cysteine depletion, respectively, while the other analyzed essential oils showed moderate reactivity with the cysteine depletion between 23.21 and 48.43%. According to DPRA predictive analysis, only Menthae longifoliae aetheroleum can be classified as negative, while all other essential oils may be classified as positive, thus having the potential to cause skin sensitization.
Irisin protects cardiomyocytes against hypoxia/reoxygenation injury via attenuating AMPK mediated endoplasmic reticulum stress
Authors: Yue Rongchuan , Lv Mingming , Lan Meide , Zheng Zaiyong , Tan Xin , Zhao Xuemei , Zhang Yulong , Pu Jun , Xu Lei , Hu Houxiang 
Published: May 2022

AbstractEndoplasmic reticulum (ER) stress plays a central role in myocardial ischemia/reperfusion (I/R) injury. Irisin has been reported to have protective properties in ischemia disease. In this study, we aimed at investigating whether irisin could alleviate myocardial I/R injury by ER stress attenuation. The in vitro model of hypoxia/reoxygenation (H/R) was established, which resembles I/R in vivo. Cell viability and apoptosis were estimated. Expressions of cleaved caspase-3, cytochrome c, GRP78, pAMPK, CHOP, and eIF2α were assessed by western blot. Our results revealed that pre-treatment with irisin significantly decreased cytochrome c release from mitochondria and caspase-3 activation caused by H/R. Irsin also reduced apoptosis and increased cell viability. These effects were abolished by AMPK inhibitor compound C pre-treatment. Also, GRP78 and CHOP expressions were up-regulated in the H/R group compared to the control group; however, irisin attenuated their expression. The pAMPK level was significantly decreased compared to the control, and this effect could be partly reversed by metformin pre-treatment. These results suggest that ER stress is associated with cell viability decreasing and cardiomyocytes apoptosis induced by H/R. Irisin could efficiently protect cardiomyocytes from H/R-injury via attenuating ER stress and ER stress-induced apoptosis.
Multicommodity routing optimization for engineering networks
Authors: Lonardi Alessandro , Putti Mario , De Bacco Caterina 
Published: May 2022

AbstractOptimizing passengers routes is crucial to design efficient transportation networks. Recent results show that optimal transport provides an efficient alternative to standard optimization methods. However, it is not yet clear if this formalism has empirical validity on engineering networks. We address this issue by considering different response functions—quantities determining the interaction between passengers—in the dynamics implementing the optimal transport formulation. Particularly, we couple passengers’ fluxes by taking their sum or the sum of their squares. The first choice naturally reflects edges occupancy in transportation networks, however the second guarantees convergence to an optimal configuration of flows. Both modeling choices are applied to the Paris metro. We measure the extent of traffic bottlenecks and infrastructure resilience to node removal, showing that the two settings are equivalent in the congested transport regime, but different in the branched one. In the latter, the two formulations differ on how fluxes are distributed, with one function favoring routes consolidation, thus potentially being prone to generate traffic overload. Additionally, we compare our method to Dijkstra’s algorithm to show its capacity to efficiently recover shortest-path-like graphs. Finally, we observe that optimal transport networks lie in the Pareto front drawn by the energy dissipated by passengers, and the cost to build the infrastructure.