bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal combined anteversion range for obtaining a wider range of motion without prosthetic impingement after total hip arthroplasty: a three-dimensional analysis study
Authors: Hidaka Ryo , Matsuda Kenta , Nakamura Masaki , Nakamura Shigeru , Kawano Hirotaka 
Published: April 2022

Abstract
Background
Obtaining a larger theoretical range of motion (ROM) is crucial to avoid prosthetic impingement after total hip arthroplasty (THA); however, no reports have examined the permissible range values of combined anteversion (CA) satisfying targeted ROM without prosthetic impingement. This retrospective study aimed to evaluate the possible postoperative CA extent that would allow meeting target ROM criteria according to Yoshimine’s theory using computed tomography (CT)-based three-dimensional motion analysis after THA.

Methods
This study included 114 patients (133 hips) who underwent cementless primary THA using a CT-based navigation system and implants (oscillation angle ≥ 135°). Implant positions were determined using Yoshimine's CA formula. Postoperative evaluation was conducted using a three-dimensional templating software for CT data. The postoperative Yoshimine’s and Widmer’s CA was calculated, and the difference between the target and postoperative values was defined as the error of Yoshimine’s CA and Widmer’s CA. Prosthetic ROM was assessed by Yoshimine’s stringent criteria for activities of daily living. Based on fulfilling these criteria, all patients were divided into the ROM (+) and ROM (−) groups. Evaluation items were compared between the two groups.

Results
There were 111 and 22 hips in the ROM (+) and ROM (−) groups, respectively. A significant difference was noted in the absolute error of Yoshimine’s and Widmer’s CA between the two groups. Using receiver operating characteristic analysis, threshold values of 6.0 (higher values indicate greater disability; sensitivity 90.9%, specificity 72.1%) for the absolute Yoshimine’s CA difference (area under the curve [AUC] 0.87, P < 0.01) and 6.9 (higher values indicate greater disability; sensitivity 68.2%, specificity 88.3%) for the absolute Widmer’s CA difference (AUC 0.83, P < 0.01) were predictors in the ROM (−) group.

Conclusions
The target range of Yoshimine’s CA (90.8° ± 6.0°) and Widmer’s CA values (37.3° ± 6.9°) was crucial in implant orientation for obtaining theoretical ROM without prosthetic impingement after THA.
Long noncoding RNA PVT1 promotes chondrocyte extracellular matrix degradation by acting as a sponge for miR-140 in IL-1β-stimulated chondrocytes
Authors: Yao Nan , Peng Sha , Wu Huai , Liu Wengang , Cai Dake , Huang Dane 
Published: April 2022

Abstract
Background
Osteoarthritis (OA) is a common degenerative joint disease, and chondrocyte extracellular matrix (ECM) degradation is one vital pathological feature of OA. Long noncoding RNA (lncRNA), a new kind of gene regulator, plays an important role in pathogenesis of many diseases like OA. Recent studies have confirmed that lncRNA plasmacytoma variant translocation 1 (PVT1) expression was upregulated in OA patients; however, its effect on ECM degradation remained unknown.

Methods
Cartilage tissue samples were obtained from 6 OA patients admitted in Guangdong Second Traditional Chinese Medicine Hospital. Chondrocytes were isolated and cultured from the collected cartilage tissue. Plasmid construction, RNA interference, cell transfection, fluorescence in situ hybridization (FISH), and pull-down assay were carried out during the research.

Results
In this study, PVT1 expression was significantly increased in chondrocytes stimulated by interleukin-1β (IL-1β). In addition, inhibition of PVT1 significantly downregulated the increased expressions of ADAM metallopeptidase with thrombospondin type 1 motif-5 (ADAMTS-5) and matrix metalloproteinase-13 (MMP-13) induced by IL-1β. Further investigation revealed that PVT1 was an endogenous sponge RNA, which directly bound to miR-140 and inhibited miR-140 expression.

Conclusion
To sum up, this study showed that PVT1 promoted expressions of ADAMTS-5 and MMP-13 as a competing endogenous RNA (ceRNA) of miR-140 in OA, which eventually led to aggravation of ECM degradation, thus providing a new and promising strategy for the treatment of OA.
Effectiveness of self-efficacy-enhancing interventions on rehabilitation following total hip replacement: a randomized controlled trial with six-month follow-up
Authors: Meng Ya , Deng Bo , Liang Xiaoyu , Li Jiangzhen , Li Liuyi , Ou Jinxia , Yu Shuping , Tan Xingxian , Chen Yumei , Zhang Meifen 
Published: April 2022

Abstract
Background
As the world’s population ages, hip replacement, a routine treatment for arthritis, has become more common. However, after surgery, rehabilitation has some limited effectiveness with postoperative complications and persistent impairments. This study aimed to explore the effect of a self-efficacy-enhancing intervention program following hip replacement on patients’ rehabilitation outcomes (self-efficacy, functional exercise compliance, hip function, activity and social participation, anxiety and depression, and quality of life).

Methods
A prospective randomized controlled trial with a repeated-measures, two-group design was conducted in a grade A general hospital in Guangdong Province, China. A total of 150 participants with a unilateral total hip replacement were recruited via convenience sampling. Participants were randomly assigned to either the self-efficacy enhancing intervention group (n = 76) or the control group (n = 74). The intervention encompassed a face-to-face education before discharge and four telephone-based follow-ups in six months after surgery. Researchers collected baseline data on one to three days after surgery, and outcomes data were collected one, three, and six months after surgery.

Results
Average age (deviation) in intervention and control group were 58 (10.32) and 59 (10.82), respectively. After six months, intervention group scored 86.83 ± 5.89 in rehabilitation self-efficacy, significantly higher than control group (72.16 ± 6.52, t = -10.820, p < 0.001) and their hip function has turned to “excellent” (90.52 ± 4.03), while that of the latter was limited to a “middle” level (78.47 ± 7.57). Statistically significant differences were found in secondary outcomes (p < 0.001). The advantage of intervention in improving quality of life was seen in the long term rather than in the early postoperative period.

Conclusions
The self-efficacy-enhancing intervention performed by nurses induced better exercise compliance and physical, psychological, and social functions after hip replacement compared with routine care. We recommend such interventions to be combined with routine care soon after hip replacement. Further research should focus on the social participation of patients with hip replacement.
Trial registration Retrospectively registered at Chinese Clinical Trial Registry (31/01/2020, No. ChiCTR2000029422, http://www.chictr.org.cn/index.aspx).
The role of TBK1 in cancer pathogenesis and anticancer immunity
Authors: Runde Austin P. , Mack Ryan , S.J. Peter Breslin , Zhang Jiwang 
Published: April 2022

AbstractThe TANK-binding kinase 1 (TBK1) is a serine/threonine kinase belonging to the non-canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by pathogen-associated molecular patterns (PAMPs), inflammatory cytokines, and oncogenic kinases, including activated K-RAS/N-RAS mutants. TBK1 primarily mediates IRF3/7 activation and NF-κB signaling to regulate inflammatory cytokine production and the activation of innate immunity. TBK1 is also involved in the regulation of several other cellular activities, including autophagy, mitochondrial metabolism, and cellular proliferation. AlthoughTBK1mutations have not been reported in human cancers, aberrant TBK1 activation has been implicated in the oncogenesis of several types of cancer, including leukemia and solid tumors withKRAS-activating mutations. As such, TBK1 has been proposed to be a feasible target for pharmacological treatment of these types of cancer. Studies suggest that TBK1 inhibition suppresses cancer development not only by directly suppressing the proliferation and survival of cancer cells but also by activating antitumor T-cell immunity. Several small molecule inhibitors of TBK1 have been identified and interrogated. However, to this point, only momelotinib (MMB)/CYT387 has been evaluated as a cancer therapy in clinical trials, while amlexanox (AMX) has been evaluated clinically for treatment of type II diabetes, nonalcoholic fatty liver disease, and obesity. In this review, we summarize advances in research into TBK1 signaling pathways and regulation, as well as recent studies on TBK1 in cancer pathogenesis. We also discuss the potential molecular mechanisms of targeting TBK1 for cancer treatment. We hope that our effort can help to stimulate the development of novel strategies for targeting TBK1 signaling in future approaches to cancer therapy.
CovidVisualized: Visualized compilation of international updated models’ estimates of COVID-19 pandemic at global and country levels
Authors: Pourmalek Farshad 
Published: April 2022

Abstract
Objectives
To identify international and periodically updated models of the COVID-19 epidemic, compile and visualize their estimation results at the global, regional, and country levels, and periodically update the compilations. This compilation can serve as an early warning mechanism for countries about future surges in cases and deaths. When one or more models predict an increase in daily cases or infections and deaths in the next one to three months, technical advisors to the national and subnational decision-makers can consider this early alarm for assessment and suggestion of augmentation of preventive measures and interventions.

Data description
Five international and periodically updated models of the COVID-19 pandemic were identified, created by: (1) Massachusetts Institute of Technology, Cambridge, (2) Institute for Health Metrics and Evaluation, Seattle, (3) Imperial College, London, (4) Los Alamos National Laboratories, Los Alamos, and (5) University of Southern California, Los Angeles. Estimates of these five identified models were gathered, combined, and graphed at global and two country levels. Canada and Iran were chosen as countries with and without subnational estimates, respectively. Compilations of results are periodically updated. Three Github repositories were created that contain the codes and results, i.e., “CovidVisualizedGlobal” for the global and regional levels, “CovidVisualizedCountry” for a country with subnational estimates–Canada, and “covir2” for a country without subnational estimates–Iran.
Breast MRI during pregnancy and lactation: clinical challenges and technical advances
Authors: Nissan Noam , Bauer Ethan , Moss Massasa Efi Efraim , Sklair-Levy Miri 
Published: April 2022

AbstractThe breast experiences substantial changes in morphology and function during pregnancy and lactation which affects its imaging properties and may reduce the visibility of a concurrent pathological process. The high incidence of benign gestational-related entities may further add complexity to the clinical and radiological evaluation of the breast during the period. Consequently, pregnancy-associated breast cancer (PABC) is often a delayed diagnosis and carries a poor prognosis. This state-of-the-art pictorial review illustrates how despite currently being underutilized, technical advances and new clinical evidence support the use of unenhanced breast MRI during pregnancy and both unenhanced and dynamic-contrast enhanced (DCE) during lactation, to serve as effective supplementary modalities in the diagnostic work-up of PABC.
A contact problem for a piezoelectric actuator on an elasto-plastic obstacle
Authors: Krejčí Pavel , Petrov Adrien 
Published: April 2022

AbstractA problem of motion of a piezoelectric actuator in contact with an elasto-plastic obstacle is reformulated as a PDE in one spatial dimension with hysteresis in the bulk and on the contact boundary. The model is shown to dissipate energy in agreement with the principles of thermodynamics. The main result includes existence, uniqueness, and continuous data dependence of solutions.
Inhibiting nuclear factor erythroid 2 related factor 2-mediated autophagy in bovine mammary epithelial cells induces oxidative stress in response to exogenous fatty acids
Authors: Chang Renxu , Sun Xudong , Jia Hongdou , Xu Qiushi , Dong Zhihao , Tang Yan , Luo Shengbin , Jiang Qianming , Loor Juan J. , Xu Chuang 
Published: April 2022

Abstract
Background
In early lactation, bovine mammary epithelial cells undergo serious metabolic challenges and oxidative stress both of which could be alleviated by activation of autophagy. Nuclear factor erythroid 2 related factor 2 (NFE2L2), a master regulator of cellular redox homeostasis, plays an important role in the regulation of autophagy and oxidative stress. Thus, the objective of this study was to investigate the role of NFE2L2-mediated autophagy on oxidative stress of bovine mammary epithelial cells in response to exogenous free fatty acids (FFA).

Results
Exogenous FFA induced linear and quadratic decreases in activities of glutathione peroxidase (GSH-Px), catalase (CAT), and superoxide dismutase (SOD), and increases in the contents of reactive oxygen species (ROS) and malondialdehyde (MDA). Protein abundance of LC3-phosphatidylethanolamine conjugate (LC3-II) and the number of autophagosomes and autolysosomes decreased in a dose-dependent manner, while protein abundance of p62 increased in cells challenged with FFA. Activation of autophagy via pre-treatment with Rap attenuated the FFA-induced ROS accumulation. Importantly, FFA inhibited protein abundance of NFE2L2 and the translocation of NFE2L2 into the nucleus. Knockdown of NFE2L2 by siRNA decreased protein abundance of LC3-II, while it increased protein abundance of p62. Furthermore, sulforaphane (SFN) pre-treatment attenuated the FFA-induced oxidative stress by activating NFE2L2-mediated autophagy.

Conclusions
The data suggested that NFE2L2-mediated autophagy is an important antioxidant mechanism in bovine mammary epithelial cells experiencing increased FFA loads.
Predicting and remembering the behaviors of social targets: how prediction accuracy affects episodic memory
Authors: Udeogu Onyinye J. , Frankenstein Andrea N. , Sklenar Allison M. , Urban Levy Pauline , Leshikar Eric D. 
Published: April 2022

AbstractBackgroundDecades of research has investigated the relationship between memory and future thinking. Although some of this work has shown that memory forms the basis of making predictions about the future, less work has investigated how the outcome of those predictions (whether consistent or inconsistent with what one predicts) is later remembered. Limited past works suggests that memory for outcomes that are consistent with what one predicts are better remembered that predictions that are inconsistent. To advance understanding of the relationship between episodic memory and future thinking, the current investigation examines how the outcome of predictions affects memory after the predicted events takes place.MethodsIn this experiment, participants first learned trait information about social targets. Then, participants imagined scenarios involving targets and the self (i.e., the participant) and made predictions about which behaviors targets would perform based on the trait information associated with targets participants learned earlier. Participants were then told the behaviors the targets actually performed (i.e., prediction outcome), which was eitherconsistentorinconsistentwith predictions, before then taking a memory test for prediction outcomes (what the social target actually did).ResultsResults showed memory for prediction-consistent outcomes was better than for prediction-inconsistent outcomes, suggesting people exhibit enhanced memory for events that are in line with predictions based on existing contents of memory (e.g., what one knows; schemas), which is in line with the limited past work in this domain.ConclusionOverall, finding better memory for prediction-consistent outcomes may reflect an adaptive function in memory, where people show enhanced memory for episodes when they play out as predicted, and aligned with the current contents of memory.
Congenital agenesis of lumbo-sacral pedicles with associated anomalies: case report with an emphasis on the use of O-arm, navigation in the management with literature review
Authors: Dave Bharat , Degulmadi Devanand , Krishnan Ajay , Mayi Shivanand , Rai RaviRanjan , Raj Aditya , Meena Umesh 
Published: April 2022

Abstract
Background
Congenital spinal pedicle agenesis is rare. The majority of cases are asymptomatic. Few present with either low back pain or radiculopathy. Pedicle screw insertion may pose difficulties in view of abnormal anatomy.

Case presentation
Between Jan 2005 and March 2021, all the data were retrospectively reviewed for the cases operated for congenital anomalies. Three such cases were operated. Case 1 had bilateral agenesis of L5 vertebra with an ectopic kidney in right iliac fossa, absent uterus, absent ovaries and vaginal atresia. Case 2 had absent S1 pedicle with conjoint left L5 nerve root. Case 3 had hypoplastic left L5 pedicle, contained disc herniation, facetal arthropathy. Pedicle screws were placed using O-arm and navigation.

Conclusion
Pedicle agenesis increases the difficulty in pedicle screw fixation and fusion. Anomalous facet and conjoint nerve root need to be looked for intraoperatively. Use of O-arm and CT navigation is of great help in getting safe and accurate anchor points for screw placement avoiding neurological injury.
Effects of ground bamboo application on weed suppression and rice production: a 3-year paddy field experiment
Authors: Lailati Masfiro , Shang Yichen , Huynh Thien Quang , Ito Koji , Katsumi Naoya , Mizuuchi Yumiko , Ino Masaya , Takashima Tadao , Usio Nisikawa 
Published: April 2022

Abstract
Background
In light of the dramatic expansion of Japan’s bamboo forests, it is necessary to develop a strategy for the effective use of bamboo biomass resources. In this study, we tested the effects of ground bamboo as an organic mulching material or soil conditioner during a 3-year, agrochemical-free rice cultivation period.

Methods
We performed field experiments in 16 experimental paddy fields and established five treatments with three or four replicates each: control, manual weeding, low-volume ground bamboo application (0.5 kg m−2), medium-volume ground bamboo application (1.0 kg m−2), and high-volume ground bamboo application (2.0 kg m−2).

Results
We observed no suppression of aquatic weeds with the ground bamboo treatments. Nevertheless, in the first year, rice yields were 1.7–1.8 times greater in the medium- and high-volume ground bamboo treatments than in the controls. In the second and third years, rice yields did not differ among treatments. During the 3-year period, mean rice yields dropped dramatically to around 20%. Simple linear regression analyses indicated that rice yields were positively associated with available phosphate, and negatively associated with the silicic acid content of post-experiment paddy soils after the second and third years of cultivation. Multiple linear regression analyses indicated that available phosphate and silicic acid were important variables explaining rice yields. Application of ground bamboo did not appear to reduce external rice grain quality.

Conclusions
Application of ground bamboo may enhance the production of high-quality rice, particularly when soil phosphorus is not deficient.
Improving the Explanation of Electoral Behavior Through a Combination of Historical and Local Context – The Case of the AfD’s Results at the Federal Election in Germany in 2017
Authors: Jäckle Sebastian 
Published: April 2022

AbstractThe purpose of this article is to examine the extent to which an approach that takes into account the historical and spatial context of an election can contribute to a better understanding of electoral dynamics in general. It applies this approach to the analysis of the results of the populist radical right party “Alternative for Germany” (AfD) at the 2017 federal election in Germany. Making use of a newly compiled dataset at the municipality level in Germany, local context will first be included in a direct way, measured by distances from the municipalities to relevant geographical markers that can be associated with a long-term or a short-term historical legacy. These spatial points include former Nazi concentration camps (main camps as well as relevant sub-camps) in order to test for the long-term legacy, first reception facilities for refugees during the so-called “refugee crisis” (2015–16) as markers of one of the most incisive developments of the recent past in Germany. Additionally, the distance to the Eastern border is tested, as this variable has proven to be relevant in the context of earlier studies on the AfD. Second, actively modeling spatial non-stationarity using Geographically Weighted Regression (GWR) in an exploratory manner shows that most effects on the strength of the AfD at the municipality level (from modernization loser theory to the contact hypothesis) vary significantly and considerably in terms of strength throughout Germany.
Urban sprawl and expansion of road networks and its impacts on the environment using sensor and socio-economic data: Macta watershed, western Algeria
Authors: Hamza Mohammed Belkebir , Abbassia Ayache , Mohammed Benyahia 
Published: April 2022

Urban sprawl and the road networks have profoundly modified the space of the Macta watershed in western Algeria. The fragmentation of the landscape within this territory is gradually changing in order to meet different socio-economic needs. Damage to natural environments caused by pollution, business development, management of agricultural land and spatial modification of the morphology of urban constructions are remarkable. Our research is part of a complex study of the rate of evolution of urban sprawl and road networks expansion from 1987 to 2018; to better understand the issues of human activities and their impacts on the environment. The methodology adopted consists of using Landsat and Google-Pro images. Their capabilities enable us to trace the influence of human activities in time and space on the environment. The results obtained show a weak trend in urban sprawl during the period 1987/1998, while it reaches significant levels in the years 2010 and 2018. The distribution of the surface area occupied by towns and cities during this study period shows a concentration of the population in the major provinces. In addition, the extension of the East-West motorway shows a weak trend in 2018. The lengths of the roads built are significant and show a 50 % growth rate. The digital analysis using sensor data has an important advantage in detecting the evolution and progression of the spaces occupied by urbanization and road networks in the Macta watershed over 31 years, which has been marked by intense demographic growth.