bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANGPTL4 Regulates Psoriasis via Modulating Hyperproliferation and Inflammation of Keratinocytes
Authors: Zuo Yuyue , Dai Lei , Li Li , Huang Yuqiong , Liu Xinxin , Liu Xin , Duan Xiaoru , Jiang Su , Deng Guo-Min , Chen Hongxiang 
Published: July 2022

Background: Psoriasis is characterized by keratinocyte proliferation and massive inflammatory leukocytes infiltration, affecting 0.14%–1.99% of the world’s population. Our aim was to identify novel potential therapeutic strategies for psoriasis.Methods: Weighted gene co-expression network analysis (WGCNA) was performed to identify gene modules that were closely related to psoriasis based on the GSE30999 dataset, which contained expression data from 85 patients with moderate-to-severe psoriasis. Then, angiopoietin-like 4 (ANGPTL4), one of the most related hub genes, was selected for in vitro and in vivo functional assays. In our experiments, imiquimod (IMQ)-induced psoriasiform dermatitis in mice and human keratinocytes (HaCaT) cells were used to study the potential roles and mechanisms of ANGPTL4 in psoriasis.Results: WGCNA analysis revealed the turquoise module was most correlated with psoriasis, and ANGPTL4 is one of the most related hub genes that significantly upregulated in psoriasis lesions compared with non-lesional skin. Consistent with the bioinformatic analysis, the expression of ANGPTL4 was significantly upregulated in IMQ-induced psoriasiform skin of mice. Exogenous recombinant ANGPLT4 protein treatment could promote the proliferation and induce the expression of inflammatory cytokines in HaCaTs, whereas silencing of ANGPTL4 effectively inhibited these effects. Then we demonstrated that recombinant ANGPTL4 protein exacerbated psoriasiform inflammation and epidermal hyperproliferation in vivo. Mechanismly, extracellular signal-regulated kinase 1/2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3) pathways were involved in ANGPTL4-mediated regulation of proliferation and inflammation.Conclusion: We found ANGPTL4 was significantly increased in IMQ-induced psoriasiform skin of mice. ANGPTL4 could promote keratinocyte proliferation and inflammatory response via ERK1/2 and STAT3 dependent signaling pathways in psoriasis.
Population Pharmacokinetics and Dosing Regimen of Lithium in Chinese Patients With Bipolar Disorder
Authors: Jin Zi-bin , Wu Zhuo , Cui Yi-fan , Liu Xue-peng , Liang Hong-bo , You Jia-yong , Wang Chen-yu 
Published: July 2022

Background: Lithium is an effective medication approved for the treatment of bipolar disorder (BD). It has a narrow therapeutic index (TI) and requires therapeutic drug monitoring. This study aimed to conduct a population pharmacokinetics (PPK) analysis of lithium and investigate the appropriateness of the dosing regimen according to different patient characteristics.Methods: A total of 476 lithium concentrations from 268 patients with bipolar disorder were analyzed using nonlinear mixed-effects modeling. Monte Carlo simulations were employed to investigate the influence of covariates, such as weight, creatinine clearance, and daily doses of lithium concentrations, and to determine the individualized dosing regimens for patients.Results: Lithium PK was described by a one-compartment model with first-order absorption and elimination processes. The typical estimated apparent clearance was 0.909 L/h−1 with 16.4% between-subject variability in the 62 kg patients with 116 ml/min creatinine clearance and 600 mg daily doses. To achieve a target trough concentration (0.4–0.8 mmol/L) in the maintenance phase, the regimen of 500 mg than 750 mg daily dose was recommended for patients with renal insufficiency and weighing 100 kg.Conclusion: A PPK model for lithium was developed to determine the influence of patient characteristics on lithium pharmacokinetics. Weight, creatinine clearance, and total daily dose of lithium can affect the drug’s clearance. These results demonstrate the nonlinear renal excretion of lithium; hence, dosage adjustments are recommended for patients with renal insufficiency.
Hepatitis B Virus Reactivation and Mycobacterial Infections Associated With Ustekinumab: A Retrospective Study of an International Pharmacovigilance Database
Authors: Wang Jingjing , Geng Xiaozhen , Zhang Xin , Xiao Yanfeng , Wang Wenjun 
Published: July 2022

Background: Reports were recently published on hepatitis B virus reactivation (HBVr), tuberculosis (TB), and atypical mycobacterial infection (AMI) in patients with ustekinumab treatment. However, the literature is limited to case reports and series. The study was aimed to investigate their relationships by using an extensive population-based database.Methods: Using the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database, we collected all cases of HBVr, TB, and AMI between 1 January 2009 and 30 September 2021, for ustekinumab and other drugs. Disproportionality was analyzed using the reporting odds ratio (ROR), which was considered significant when the lower limit of the 95% confidence interval (95% CI) was &gt;1.Results: Of the 18,760,438 adverse cases reported to FAERS for all drugs, 56,581 cases had been exposed to ustekinumab. Adverse events of HBVr, TB, and AMI were reported in 21, 210, and 20 cases, respectively. The ROR for HBVr with ustekinumab was 2.33 (95% CI, 1.52–3.58), for TB was 5.09 (95% CI, 4.44–5.84), and for AMI was 2.09 (95% CI, 1.35–3.24). In the ustekinumab exposure group, no death occurred in patients with HBVr, but one patient experienced life-threatening liver failure. For those with TB, 24 cases experienced hospitalization and 2 deaths occurred. No death occurred in patients with AMI but eight experienced hospitalization.Conclusion: We identified positive signals between ustekinumab exposure and HBVr, TB, and AMI in FAERS. Although these complications are rare, clinicians using ustekinumab should be aware of the risks.
Exercise-Induced Atrial Remodeling in Female Amateur Marathon Runners Assessed by Three-Dimensional and Speckle Tracking Echocardiography
Authors: Lasocka Zofia , Lewicka-Potocka Zuzanna , Faran Anna , Daniłowicz-Szymanowicz Ludmiła , Nowak Radosław , Kaufmann Damian , Kaleta-Duss Anna , Kalinowski Leszek , Raczak Grzegorz , Lewicka Ewa , Dąbrowska-Kugacka Alicja 
Published: July 2022

Endurance athletes have an increased risk of atrial remodeling and atrial arrhythmias. However, data regarding atrial adaptation to physical exercise in non-elite athletes are limited. Even less is known about atrial performance in women. We aimed to elucidate exercise-induced changes in atrial morphology and function in female amateur marathon runners using three-dimensional (3D) echocardiography and two-dimensional (2D) speckle tracking echocardiography (STE). The study group consisted of 27 female (40 ± 7 years) amateur athletes. Right (RA) and left atrial (LA) measures were assessed three times: 2–3 weeks before the marathon (stage 1), immediately after the run (stage 2), and 2 weeks after the competition (stage 3). Directly after the marathon, a remarkable RA dilatation, as assessed by RA maximal volume (RAVmax, 31.3 ± 6.8 vs. 35.0 ± 7.0 ml/m2; p = 0.008), with concomitant increase in RA contractile function [RA active emptying fraction (RA active EF), 27.7 ± 8.6 vs. 35.0 ± 12.1%; p = 0.014; RA peak atrial contraction strain (RA PACS) 13.8 ± 1.8 vs. 15.6 ± 2.5%; p = 0.016] was noticed. There were no significant changes in LA volumes between stages, while LA active EF (34.3 ± 6.4 vs. 39.4 ± 8.6%; p = 0.020), along with LA PACS (12.8 ± 2.1 vs. 14.9 ± 2.7%; p = 0.002), increased post race. After the race, an increase in right ventricular (RV) dimensions (RV end-diastolic volume index, 48.8 ± 11.0 vs. 60.0 ± 11.1 ml/m2; p = 0.001) and a decrease in RV function (RV ejection fraction, 54.9 ± 6.3 vs. 49.1 ± 6.3%; p = 0.006) were observed. The magnitude of post-race RV dilatation was correlated with peak RA longitudinal strain deterioration (r = −0.56, p = 0.032). The measured parameters did not differ between stages 1 and 3. In female amateur athletes, apart from RV enlargement and dysfunction, marathon running promotes transient biatrial remodeling, with more pronounced changes in the RA. Post-race RA dilatation and increment of the active contraction force of both atria are observed. However, RA reservoir function diminishes in those with post-race RV dilation.
Quality Assessment of the Clinical Practice Guidelines of Ostomy Care Based on the AGREE II Instrument
Authors: Li Xiaoyu , Yuan Qiao , Geng Liangrong , Chen Zhiqi , Zhang Rui , Guo Liqun , Yue Shujin 
Published: July 2022

ObjectivesTo assess the quality of clinical practice guidelines (CPGs) of ostomy care, and to analyze the status quo and challenges of guideline development.MethodsCPGs of ostomy care were systematically searched in relevant guideline websites and electronic databases, including PubMed, ProQuest, Web of Science, CNKI, VIP, WANFANG, and SinoMed, from January 1, 2012, to November 24, 2021. Two appraisers used the Appraisal of Guidelines for Research and Evaluation, 2nd edition (AGREE II) instrument to assess the quality of the included CPGs independently and objectively. The consistency of assessment was calculated using intraclass correlation coefficients (ICC).ResultsA total of 5 CPGs relevant to ostomy care were assessed by AGREE II and the general quality of them was good. There were two CPGs of grade A and three CPGs of grade B. The domain scope and purpose (87.78%) had the highest scores, followed by the clarity of presentation (87.22%), the rigor of development (69.17%), stakeholder involvement (68.33%), and editorial independence (65.00%), and the lowest was applicability (55.42%). The overall assessment score was 5.40. All the ICCs for the AGREE II appraisal conducted by the two appraisers were &gt;0.75.ConclusionsThe five CPGs of ostomy care have the potential to be adopted in clinical practice. However, they still have some room for improvement, especially in the applicability domain. The development of ostomy care CPGs should follow the evidence-based progress and methodology of guideline formulation specifications while considering the effects of the CPGs and the practical issues.
Characteristics of Hospital Workers Using a Wellbeing Center Implemented During the COVID-19 Pandemic to Prevent the Emotional Impacts of the Crisis
Authors: d'Ussel Marguerite , Adam Frédéric , Fels Audrey , Chatellier Gilles , Philippart François 
Published: July 2022

IntroductionThe COVID-19 pandemic has posed an unprecedented challenge worldwide for healthcare workers (HCWs) and other hospital employees. Disruptions in work and personal life may have led to mental health problems. To prevent or limit the severity of such issues, a local initiative has been implemented in a French hospital: a dedicated lounge, also called “Bulle” (literally bubble and meaning safe space) has been created to provide a quiet caring environment and health support. Other similar wellbeing centers have been implemented in other countries, but very little data are available on their practical effectiveness. The purpose of our study was to assess what type of hospital workers have frequented the Bulle and to describe their psychological state in terms of anxiety, depression, and post-traumatic stress disorder (PTSD) just after the first wave, compared to those who had not come to the Bulle.MethodsFrom 15 July to 1 October 2020, a cross-sectional survey was conducted among all workers, collecting demographic information, professional data (experience and satisfaction), emotional experience during the first wave of COVID-19, and psychological specificities, including a history of burnout or symptoms of anxiety, depression, and PTSD. We asked them if they had accessed the Bulle or not.ResultsA total of 675 employees (out of 2,408; 28.0%) fully completed the survey. Approximately 199 respondents (29%) reported having accessed the Bulle during the first wave of the pandemic. Significant symptoms of anxiety, depression, and PTSD were reported by, respectively, 41, 20, and 14% of the participants. Logistic regression analysis showed no relationship between the use of the Bulle and the prevalence of later psychological symptoms. However, employees who benefit from the solicitation of the psychological support team in their hospital unit were secondarily more prone to come to the Bulle [odds ratio (OR), 2.24; 95% confidence interval (95% CI): 1.09; 4.59].ConclusionAnxiety, depression, and PTSD were common after the first part of the COVID-19 pandemic, and the attendance in quiet and wellbeing spaces seemed easier with direct internal proactive intervention by psychological teams.
Surgical Management of Hirschsprung's Disease: A Comparative Study Between Conventional Laparoscopic Surgery, Transumbilical Single-Site Laparoscopic Surgery, and Robotic Surgery
Authors: Li Wei , Lin Minghui , Hu Hai , Sun Quanfeng , Su Cheng , Wang Congjun , Li Yanqiang , Li Yong , Chen Jiabo , Luo Yige 
Published: July 2022

BackgroundHirschsprung's disease (HD) is a commonly digestive malformation in children that usually requires surgery. This study aims to evaluate the short-term efficacy of conventional laparoscopic surgery (CLS), transumbilical single-hole laparoscopic surgery (TU-LESS), and robotic surgery (RS) in the treatment of Hirschsprung's disease.Methods90 patients with Hirschsprung's disease undergone laparoscopic surgery at our center between 2015 and 2019, divided into three groups (group CLS, TU-LESS and RS), were retrospectively analysed.ResultsCLS and TU-LESS group showed no significant difference in operation duration (P &gt; 0.05) but shorter operation duration than the RS group (P &lt; 0.05). RS group had highest overall SCAR scores, while TU-LESS group had the lowest one (P &lt; 0.05). Other parameters such as operative blood loss, hospital stays, recovery time of digestive function, postoperative complications had no significant difference among the three groups (P &gt; 0.05).ConclusionThe three surgical methods for HD revealed similar efficacy, where TU-LESS and CLS spent less time than RS; TU-LESS led to the most aesthetic effect, followed by CLS and RS.
Implementasi Metode Perhitungan Aktuaria Program Dana Pensiun Menggunakan Flask
Authors: Izzati Muthia Dishanur , Kartikasari Mujiati Dwi 
Published: July 2022

The pension fund program is a program that seeks future planning by providing pension benefits to participants. The vital thing that becomes a concern in the pension fund program is the actuarial cost method. There are two categories for actuarial cost methods, which are Accrued Benefit-Cost Method and Projected Benefit-Cost Method. The normal contribution characteristic of the Projected Benefit-Cost Method is more stable than the Accrued Benefit-Cost Method, so it is better to use it from the participants’ perspective. This study discusses the use of the Projected Benefit-Cost Method by calculating normal contributions and actuarial liabilities from the methods included in it, which are Attained Age Normal, Entry Age Normal, and Individual Level Premium. Based on the calculation results, the Entry Age Normal and Individual Level Premium methods have a smaller final value of normal contribution payments and have a larger actuarial liability than the Attained Age Normal. Thus, of the three methods included in the Projected Benefit-Cost Method, the Entry Age Normal and Individual Level Premium methods are better used from the perspective of participants. For the calculation of pension funding using the Attained Age Normal, Entry Age Normal, and Individual Level Premium methods to be widely implemented by the public, this study created an application website using flask, which can be accessed at https://perhitunganaktuariadapen.herokuapp.com/.
Metode Reversible Self-Dual untuk Konstruksi Kode DNA atas Lapangan Hingga GF(4)
Authors: Butar-Butar Juli Loisiana , Bukit Misa Br. 
Published: July 2022

The DNA molecule chain consists of two complementary strands composed of a sequence of four nucleotide bases, namely adenine (A), cytosine (C), guanine (G) and thymine (T). DNA code is a set of codewords with a fixed length of the alphabet {A, C, T, G}. DNA coding is one application of coding theory over a finite field. The set {A, C, T, G} is identified as finite field GF(4) = {0, 1, w, w2} with w2 + w + 1 = 0. The reversible self-dual (RSD) code over the finite field GF(4) is a code whose dual is itself and the reverse of each codeword contained in the code. This study aims to obtain an algorithm to construct a DNA code derived from the RSD C code on the field to GF(4) which is called the Reversible Self-Dual Method. The aspects studied include the characteristics that form the basis properties of the theory in compiling the DNA code algorithm over the RSD code over GF(4). The compiled algorithm is a DNA code construction method of codeword length even that conforms to the Hamming distance constraint, reverse-complement constraint, and GC-content constraint. The input of the algorithm is a generator matrix of RSD code C with a minimum distance of d and the output is a DNA code that satisfies these three constraints.
Bilangan Invers Dominasi Total Pada Triangular Snake Graph, Line Triangular Snake Graph, dan Shadow Triangular Snake Graph
Authors: Nurhamzah Nurhamzah , Kusumastuti Nilamsari , Fran Fransiskus 
Published: July 2022

Let G = (V(G), E(G)) be a connected graph, where V(G) is the set of vertices and E(G) is the set of edges. The set Dt(G) is called the total domination set in G if every vertex v 2 V(G) is adjacent to at least one vertex in Dt (G). Furthermore, Dt(G) must satisfy the property N(Dt ) = V(G), where N(Dt) is an open neighbourhood set of Dt(G). Suppose that Dt(G) is the total domination set with minimum cardinality. If V(G) - Dt(G) contains a total domination set Dt-1(G), then Dt-1(G) is the inverse set of total domination relative to the total domination set Dt (G). The inverse’s number of the total domination set denotes the minimum cardinality of the inverse set of total domination. This number is denoted by gt-1 (G). This article discusses the inverse’s number of total domination of the triangular snake graph (Tn), line triangular snake graph (L (Tn)), and shadow triangular snake graph (D2 (Tn)). Graph Tn is a graph obtained from the path graph (Pn) by replacing each side of the path with a cycle graph (C3). Graph L (Tn) is a graph where the vertex set in L(Tn) is the edge set on Tn, or V(L(Tn)) = E(Tn). Graph D2 (Tn) is a graph obtained by combining two copies of a graph Tn, namely Tn0 and T00n. This research shows that the graph Tn does not have an inverse of domination total, gt-1 (L (Tn)) = n for n = 4, 6, 8, gt-1 (L (Tn)) = n - 1 for n = 3, 5, 7, or n ≥ 9 with n 2 N, and gt-1 (D2 (Tn)) = b23nc for n ≥ 3 with n 2 N.
Changes in Platelet Aggregation in Patients with Localized Scleroderma
Authors: Порошина Л.А. , Бакалец Н.Ф. 
Published: July 2022

Обследованы 63 пациента с ограниченной склеродермией (59 женщин и 4 мужчины), которые находились на стационарном лечении в Гомельском областном клиническом кожно-венерологическом диспансере. При оценке данных агрегатограммы были установлены как снижение, так и повышение агрегации тромбоцитов. Выявлено, что у пациентов, страдающих ограниченной склеродермией, преобладала гипоагрегация тромбоцитов с укорочением времени агрегации. Скорость агрегации тромбоцитов у большинства пациентов соответствовала нормальным значениям. Выявленный факт требует дальнейшего изучения.
63 patients with limited scleroderma, 59 women and 4 men, who were hospitalized in the Gomel Regional Clinical Dermatovenerologic Dispensary, were examined. When evaluating the aggregogram data, both a decrease and an increase in platelet aggregation were revealed. It was revealed that in patients suffering from limited scleroderma, platelet hypoaggregation with a shortening of the aggregation time predominated. The rate of platelet aggregation in most patients corresponded to normal values. The revealed fact requires further study.
Factors Related to the Implementation of Patient Safety Targets (SKP) on Nurses Privat Hospital X in Yogyakarta
Authors: Hastuti Siti kurnia widi , Yunita Vera 
Published: July 2022

Latar Belakang : Keselamatan pasien (patient safety) merupakan kondisi medis yang intens ke seluruh dunia. Akhir-akhir ini, negara-negara telah memahami pentingnya keamanan pasien.
Tujuan Penelitian : Mengetahui faktor–faktor yang berhubungan dengan implementasi sasaran keselamatan pasien pada perawat rumah sakit X di Yogyakarta.
Metode Penelitian: jenis penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif dengan pendekatan crosv-secftional., karena cross-sectional paling cocok untuk penelitian ini. Tehnik sampling yang digunakan yaitu proportionet random ampling dengan sampel sebanyak 74 orang. Dan analisis yang digunakan adalah univariate dan bivariate pengolahan data denga chi-square.
Hasil Penelitian: sebanyak 51 perawat (68,9%) memiliki tingkat pengetahuan baik dimana hassil ufji statistic menunjufkkan nfilai p-value sebesfar 0,001 (p value< 0,05) yang artinya Ho ditolak yaitu ada hubungan antara pengetahuan dengan implementasi sasaran keselamatan pasien, sebanyak 42 perawat (56,8%) memiliki sikap baik dimana hasil uji statistic menunjukkan nilai p value sebesar 0,032 (p value< 0,05) yang artinya Ho ditolak yaitu ada hubungan antara sikap dengan implementasi sasaran keselamatan pasien, dan lama kerja perawat >3 tahun sebanyak 49 perawat (66,2%) dimana hasil uji statistic menunjukkan nilai p value sebesar 0,004 (p value<0,05) yang artinya Ho ditolak yaitu ada hubungan antara lama kerja dengan implementasi sasaran keselamatan pasien rumah sakit swasta X di Yogyakarta.
Kesimpuulan: Ada hubungan antara pengetahuan dengan implementasi sasaran keselamatan pasien, ada hubungan antara sikap dengan implementasi sasaran keselmatan pasien, ada hubungan antara lama kerja dengan implementasi sasaran keselamatan pasien di RS Swasta X di Yogyakarta.
Phubbing en los adolescentes un comportamiento que afecta la interacción social. Una revisión sistemática
Authors: Guzmán-Brand Víctor , Gelvez-García Laura 
Published: July 2022

Introducción: Los dispositivos electrónicos como los smartphones han cambiado la forma de relacionarnos, nos atrapan en un bucle interminable lleno de actividades en razón a plataformas, aplicaciones y actualizaciones que absorben lo mejor del ser humano, su habilidad de comunicación. Objetivo: Conocer las características del phubbing en los adolescentes siendo un comportamiento que afecta la interacción social. Metodología: Se emplea una revisión sistemática en razón a las directrices de la declaración PRISMA 2020 de fuentes primarias de información, explorando las bases de datos y motores de búsqueda. Resultados: El uso desmedido de los smartphone y redes sociales propician el fenómeno social del phubbing. Además, condiciona como necesidad la utilización del equipo electrónico en ambientes de relación comunicativa. Conclusiones: El phubbing es un comportamiento que lleva a los adolescentes al empleo excesivo del smartphone en contextos de vinculación comunicativa es así como, esta conducta se focaliza en desentenderse de las personas en un ambiente social por estar conectado al teléfono.