bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Jacobi capture origin of binaries with applications to the Earth-Moon system and black holes in galactic nuclei
Authors: Boekholt Tjarda C N , Rowan Connar , Kocsis Bence 
Published: December 2022

ABSTRACT
Close encounters between two bodies in a disc often result in a single orbital deflection. However, within their Jacobi volumes, where the gravitational forces between the two bodies and the central body become competitive, temporary captures with multiple close encounters become possible outcomes: a Jacobi capture. We perform three-body simulations in order to characterize the dynamics of Jacobi captures in the plane. We find that the phase space structure resembles a Cantor-like set with a fractal dimension of about 0.4. The lifetime distribution decreases exponentially, while the distribution of the closest separation follows a power law with index 0.5. In our first application, we consider the Jacobi capture of the Moon. We demonstrate that both tidal captures and giant impacts are possible outcomes. The impact speed is well approximated by a parabolic encounter, while the impact angles follow that of a uniform beam on a circular target. Jacobi captures at larger heliocentric distances are more likely to result in tidal captures. In our second application, we find that Jacobi captures with gravitational wave dissipation can result in the formation of binary black holes in galactic nuclei. The eccentricity distribution is approximately superthermal and includes both prograde and retrograde orientations. We conclude that dissipative Jacobi captures form an efficient channel for binary formation, which motivates further research into establishing the universality of Jacobi captures across multiple astrophysical scales.
Dust motion and possibility of dust growth in a growing circumstellar disk
Authors: Koga Shunta , Machida Masahiro N 
Published: December 2022

ABSTRACT
We calculate the evolution of a star-forming cloud core using a three-dimensional resistive magnetohydrodynamics simulation, treating dust grains as Lagrangian particles, to investigate the dust motion in the early star formation stage. We prepare six different-sized set of dust particles in the range ad = 0.01–$1000\, \mu$m, where ad is the dust grain size. In a gravitationally collapsing cloud, a circumstellar disk forms around a protostar and drives a protostellar outflow. Almost all the small dust grains (ad ≲ 10–$100\, \mu$m) initially distributed in the region θ0 ≲ 45° are ejected from the center by the outflow, where θ0 is the initial zenith angle relative to the rotation axis, whereas only a small number of the large dust grains ($a_{\rm d} \gtrsim 100\, \mu$m) distributed in the region are ejected. All other grains fall onto either the protostar or disk without being ejected by the outflow. Regardless of the dust grain size, the behavior of the dust motion is divided into two trends after dust particles settle into the circumstellar disk. The dust grains reaching the inner disk region from the upper envelope preferentially fall onto the protostar, while those reaching the outer disk region or disk outer edge from the envelope can survive without an inward radial drift. These surviving grains can induce dust growth. Thus, we expect that the outer disk regions could be a favored place of planet formation.
The Solar system test for the general modified gravity theories
Authors: Chan Man Ho , Lee Chak Man 
Published: December 2022

ABSTRACT
In the past few decades, various versions of modified gravity theories were proposed to mimic the effect of dark matter. Compared with the conventional Newtonian or relativistic dynamics, these theories contain some extra apparent force terms in the dynamical equations to replace the role of dark matter. Generally speaking, the extra apparent force terms usually scale with radius so that the effect would be significant only on large scale to explain the missing mass in galaxies or galaxy clusters. Nevertheless, the apparent effect may still be observable in small structures like the Solar system. In this paper, we derive analytic general formulae to represent the contribution of the precession angle of the planets in the Solar system due to the general modified gravity theories, in which the extra apparent force terms can be written in a power law of radius r or an exponential function in r. We have tested three popular modified gravity theories, the modified Newtonian dynamics (MOND), the emergent gravity (EG), and the modified gravity. In particular, based on the Solar system data, we have constrained the parameters involved for two popular general interpolating functions used in MOND. Our results can be generally applied to both of the modified inertia and modified gravity versions of MOND.
Moving groups across Galactocentric radius with Gaia DR3
Authors: Lucchini Scott , Pellett Emil , D’Onghia Elena , Aguerri J Alfonso L 
Published: December 2022

ABSTRACT
The kinematic plane of stars near the Sun has proven an indispensable tool for untangling the complexities of the structure of our Milky Way (MW). With ever improving data, numerous kinematic ‘moving groups’ of stars have been better characterized, and new ones continue to be discovered. Here we present an improved method for detecting these groups using MGwave, a new open-source 2D wavelet transformation code that we have developed. Our code implements similar techniques to previous wavelet software; however, we include a more robust significance methodology and also allow for the investigation of underdensities, which can eventually provide further information about the MW’s non-axisymmetric features. Applying MGwave to the latest data release from Gaia (DR3), we detect 47 groups of stars with coherent velocities. We reproduce the majority of the previously detected moving groups in addition to identifying three additional significant candidates: one within Arcturus, and two in regions without much substructure at low VR. Finally, we have followed these associations of stars beyond the Solar neighbourhood from Galactocentric radius of 6.5–10 kpc. Most detected groups are extended throughout radius indicating that they are streams of stars possibly due to non-axisymmetric features of the MW.
Combining photometry and astrometry to improve orbit retrieval of directly imaged exoplanets
Authors: Bruna Margaret , Cowan Nicolas B , Sheffler Julia , Haggard Hal M , Bourdon Audrey , Mâlin Mathilde 
Published: December 2022

ABSTRACT
Future missions like Roman, HabEx, and LUVOIR will directly image exoplanets in reflected light. While current near-infrared direct imaging searches are only sensitive to young, self-luminous planets whose brightness is independent of their orbital phase, reflected light direct imaging will reveal changes in planet brightness throughout an orbit due to phase variations. One of the first objectives will be determining the planet’s orbit via astrometry, the projected position of the planet with respect to its host star in the sky plane. We show that phase variations can significantly improve the accuracy and precision of orbital retrieval with two or three direct images. This would speed up the classification of exoplanets and improve the efficiency of subsequent spectroscopic characterization. We develop a forward model to generate synthetic observations of the 2D astrometry and the planet/star flux ratio. Synthetic data are fitted with Keplerian orbits and Henyey–Greenstein phase variations to retrieve orbital and phase parameters. For astrometric uncertainties of 0.01 au in projected separation and flux ratio uncertainties of 10−12, using photometry in orbit retrieval improves the accuracy of semimajor axis by 47 per cent for two epochs and 61 per cent for three epochs if the phase curves have a known shape, but unknown amplitude. In a realistic scenario where phase curve shape and amplitude are a priori unknown, photometry improves accuracy by 16 per cent for two epochs and 50 per cent for three epochs. In general, we find that if the planetary flux is measured to better than 10σ at multiple epochs, it usefully contributes to orbit retrieval.
The flat entropy profile at the outskirts of the Abell 2244 galaxy cluster
Authors: Andreon S , Moretti A , Böhringer H , Castagna F 
Published: December 2022

ABSTRACT
Entropy is an advantageous diagnostics to study the thermodynamic history of the intracluster plasma of galaxy clusters. We present the entropy profile of the Abell 2244 galaxy cluster derived both exclusively using X-ray data from the low-background Swift XRT telescope and using the Planck y data. The entropy profile derivation using X-rays only is robust at least to the virial radius because the cluster brightness is large compared to the X-ray background at low energies, the temperature is strongly bounded by the lack of cluster X-ray photons at energies kT &gt; 3 keV, and the XRT background is low, stable, and understood. In the observed solid angle, about one quadrant, the entropy radial profile deviates from a power law at the virial radius, mainly because of a sharp drop in the cluster temperature. This bending of the entropy profile is confirmed when X-ray spectral information is replaced by the Compton map. Clumping and non-thermal pressure support are insufficient to restore a power-law entropy profile because they are bound to be small by: (i) the agreement between mass estimates from different tracers (gas and galaxies), (ii) the agreement between entropy profile determinations based on combinations of observables with different sensitivities and systematics, and (iii) the low value of clumping as estimated using the azimuthal scatter and the gas fraction. Based on numerical simulations, ion–electron equilibration is also insufficient to restore a linear entropy profile. Therefore, the bending of the entropy profiles seems to be robustly derived and witnesses the theoretically predicted decrease in the inflow through the virial boundary.
Characterization of the spatial distribution of metals and profile of metalloprotein complexes in a mouse model of repetitive mild traumatic brain injury
Authors: Juan Sydney M A , Daglas Maria , Gunn Adam P , Lago Larissa , Adlard Paul A 
Published: December 2022

Abstract
Metal dyshomeostasis is a well-established consequence of neurodegenerative diseases and traumatic brain injury. While the significance of metals continues to be uncovered in many neurological disorders, their implication in repetitive mild traumatic brain injury remains uncharted. To address this gap, we characterized the spatial distribution of metal levels (iron, zinc, and copper) using laser ablation–inductively coupled plasma–mass spectrometry, the profile of metal-binding proteins via size exclusion chromatography–inductively coupled plasma–mass spectrometry and the expression of the major iron storing protein ferritin via western blotting. Using a mouse model of repetitive mild traumatic brain injury, 3-month-old male and female C57Bl6 mice received one or five impacts (48 h apart). At 1 month following 5× TBI (traumatic brain injury), iron and ferritin levels were significantly elevated in the contralateral cortex. There was a trend toward increased iron levels in the entire contralateral hemisphere and a reduction in contralateral cortical iron-binding proteins following 1× TBI. No major changes in zinc levels were seen in both hemispheres following 5× or 1× TBI, although there was a reduction in ipsilateral zinc-binding proteins following 5× TBI and a contralateral increase in zinc-binding proteins following 1× TBI. Copper levels were significantly increased in both hemispheres following 5× TBI, without changes in copper-binding proteins. This study shows for the first time that repetitive mild TBI (r-mTBI) leads to metal dyshomeostasis, highlighting its potential involvement in promoting neurodegeneration, which provides a rationale for examining the benefit of metal-targeting drugs, which have shown promising results in neurodegenerative conditions and single TBI, but have yet to be tested following r-mTBI.
Vitamin K supplementation and bone mineral density in dialysis: results of the double-blind, randomized, placebo-controlled RenaKvit trial
Authors: Levy-Schousboe Karin , Marckmann Peter , Frimodt-Møller Marie , Peters Christian D , Kjærgaard Krista D , Jensen Jens D , Strandhave Charlotte , Sandstrøm Hanne , Hitz Mette F , Langdahl Bente , Vestergaard Peter , Brasen Claus L , Schmedes Anne , Madsen Jonna S , Jørgensen Niklas R , Frøkjær Jens B , Frandsen Niels E , Petersen Inge , Hansen Ditte 
Published: December 2022

ABSTRACT

Background
Vitamin K deficiency is highly prevalent in patients on dialysis and may contribute to their low bone mineral density (BMD) and increased risk of fracture. This study investigated the effect of menaquinone-7 (MK-7) supplementation on BMD in patients on chronic dialysis.

Methods
In a multicentre, double-blind, placebo-controlled intervention trial, 123 patients on chronic dialysis were randomised to a daily oral supplement of either MK-7 360 µg or placebo for 2 years. BMD of the distal radius (1/3, mid, ultradistal and total), femoral neck, lumbar spine (L1–L4) and whole body was assessed by dual-energy X-ray absorptiometry. Serum levels of vitamin K1 and MK-7 and plasma levels of total osteocalcin, dephosphorylated-uncarboxylated matrix Gla protein and protein induced by vitamin K absence II were measured to assess vitamin K status.

Results
After 2 years, an accelerated BMD loss of the 1/3 distal radius was found with MK-7 supplementation {mean difference of changes relative to placebo −0.023 g/cm2 [95% confidence interval (CI) −0.039 to −0.008]}, whereas the decrease in lumbar spine BMD seen in the placebo group was prevented [mean difference of changes between groups 0.050 g/cm2 (95% CI 0.015–0.085)]. No significant effects were observed at the remaining skeletal sites. Vitamin K status strongly improved in MK-7-supplemented participants.

Conclusion
Compared with placebo, an accelerated BMD loss of the 1/3 distal radius was found after 2 years of MK-7 supplementation, whereas a decline in lumbar spine BMD was prevented. As such, MK-7 supplementation might modify BMD site-specifically in patients on dialysis. In aggregate, our findings do not support MK-7 supplementation to preserve bone in patients on dialysis.
SPDR-5 ESTABLISHMENT OF A CONTINUOUS CULTURE METHOD FOR MENINGIOMAS AND THE EFFECTS OF THE GREM2-BMP SIGNALLING PATHWAY ON PROLIFERATION AND ANGIOGENESIS
Authors: Yokogami Kiyotaka , Mizuguchi Asako , Watanabe Takashi , Matsumoto Fumitaka , Yamashita Shinji , Takeshima Hideo 
Published: December 2022

Abstract

Purpose
Meningiomas are closely related to osteogenesis, including calcification and hyperostosis at the site of attachment. Signaling pathways involved in tumor formation and extension of meningioma have not yet been elucidated. Treatment options include surgical removal and radiotherapy, but there are no reports of effective drug treatment. This is due to the difficulty of culturing non-malignant meningiomas, which has made basic experiments difficult. In this study, we established a continuous culture method for meningiomas and investigated the signaling pathways involved in meningioma growth.

Methods
67 consecutive cases of meningiomas treated in our department for three years from Apr, 2019 to March, 2022. Primary continuous culture was performed by modifying the conditional reprogramming (CR) method. Sixty-four cases were studied, excluding three cases in which culture was abandoned due to contamination. The mean age was 62.6 years, Grade 3 (6%), Grade 2 (14%) and Grade 1 (80%). These were used to observe morphology, proliferation and genetic analysis involved in angiogenesis.

Results
1) Sustained culture lasted an average of 150 days with no differences between Grades; 2) Inhibition of BMP signaling involved in osteogenesis suppressed cell proliferation regardless of Grade, and the IC50 of the inhibitor suggested the involvement of the receptor ALK3; 3) We identified GREM2 as upstream regulator of BMP signals 4) GREM2 is highly expressed in menigotherial meningiomas and immunostaining showed strong expression around whole and calcified areas. 5) GREM2 expression is negatively correlated with MIB-1 L.I., so overexpression of GREM2 in malignant meningioma cells decreased ID, which is involved in proliferation downstream of BMP signaling, and increased angiogenic factor VEGFA, which is involved in proliferation.

Conclusion
A method for the continuous culture of meningiomas was established. Using this experimental system, we identified the involvement of the GREM2-BMP signaling pathway in proliferation and angiogenesis in meningiomas as well as calcification.
GEN-13 PAIRED MUTATIONAL ANALYSIS IN SECONDARY NERVOUS SYSTEM LYMPHOMA AND PCNSL SYSTEMIC RELAPSE REVEALS DRIVER MUTATION CANDIDATES IN THE CENTRAL NERVOUS SYSTEM
Authors: Sasaki Nobuyoshi , Kume Satoshi , Tateishi Kensuke , Nakamura Taishi , Ibayashi Kenji , Yamagishi Yuki , Saito Kuniaki , Kobayashi Keiichi , Matsushita Yuko , Hibiya Yuko , Kitahara Mai , Suzuki Saki , Nagano Reiko , Yamashita Satoshi , Nakatomi Hirofumi , Shiokawa Yoshiaki , Ichimura Koichi , Nagane Motoo 
Published: December 2022

Abstract
Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non-Hodgkin lymphoma confined to the brain, eyes, and the spinal cord. The mechanism of central nervous system (CNS) tropism in PCNSL has not been fully elucidated. Diffuse large B cell lymphomas (DLBCLs) occasionally present with distant recurrence, which can involve inside and outside the CNS. Secondary central nervous system lymphomas (SCNSLs) are CNS relapse of systemic lymphoma. PCNSLs also rarely present with systemic relapse. We have previously reported in our study of whole exome sequencing that PCNSLs harbor frequent mutations in genes of B cell receptor pathway members and aberrant somatic hypermutation (aSHM) target genes. Although several genetic alterations were identified as more frequent in PCNSLs compared with systemic lymphomas, specific genetic alterations which serve as the driver for CNS tropism in PCNSLs has not been identified. In order to search for mutations which might serve as driver mutations in the CNS, we have performed targeted sequencing in paired samples from patients with recurrent lymphomas, either SCNSLs or PCNSL systemic relapses, using Ion Torrent multiplex PCR. Mutational profiles were compared between the primary and recurrent tumor. Six cases (four SCNSL cases and two PCNSL systemic relapse cases) were analyzed. Of note, in the SCNSL cases, several de novo mutations were enriched only among the recurrent CNS tumors. Among these mutations, BTG2 mutations were observed in 3/4 (75%), and B2M and KLHL14 mutations were observed in 2/4 (50%) cases. In the two PCNSL systemic relapse cases, KMT2D mutations were enriched only in the recurrent systemic tumors. It is suggested that these de novo mutations in the recurrent CNS tumors might serve as driver mutations in the CNS. Further analysis in larger cohorts, and functional studies are required in order to validate these findings.
ET-7 EVALUATION OF HYPOXIA-TARGETING RADIOPHARMACEUTICAL64CU-ATSM FOR PET MONITORING WITH LOCAL THERAPY IN HIGH-GRADE GLIOMA MODEL
Authors: Yoshii Yukie , Hihara Fukiko , Matsumoto Hiroki , Igarashi Chika , Tachibana Tomoko , Shinada Mitsuhiro , Ming-Rong Zhang , Oshima Akito , Sato Hidemitsu , Narita Yoshitaka , Kurihara Hiroaki , Yamamoto Tetsuya , Higashi Tatsuya , Tateishi Kensuke 
Published: December 2022

Abstract
World Health Organization (WHO)-defined central nervous system (CNS) grade 4 high-grade gliomas (HGGs) are highly aggressive brain cancers characterized by the presence of hypoxia within a rapidly-growing tumor mass. Due to invasion to the surrounding brain parenchyma, these tumors commonly recur locally, despite aggressive surgical resection, and new therapeutic approaches are required for local tumor control. Here, we show a positron emission tomography (PET) integrated local therapy (PETx), to target HGGs. This technique consists of a one-step local theranostic application, followed by PET monitoring, with a hypoxia-targeting radiopharmaceutical 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM). We examined the safety and therapeutic potential of 64Cu-ATSM PETx for HGG patient-derived xenograft (PDX) tumors, which recapitulated the parent tumor phenotype of high expression of hypoxia-inducible factor-1α and BNIP3, biomarkers of tissue hypoxia. Biodistribution, dosimetry, and toxicity studies of 64Cu-ATSM local administration determined the maximum tolerated dose (MTD) to be 3.7 MBq in mouse. PETx using the MTD dose of 64Cu-ATSM indicated high tumor penetration, distribution, and retention of 64Cu-ATSM in PDX tumors, as compared to sham-treated mice. The 64Cu-ATSM PETx promoted DNA double-strand breaks, followed by apoptosis in tumors, and extensively prolonged overall survival with tolerable systemic toxicity. These findings indicate the potential of 64Cu-ATSM PETx to induce high uptake in the hypoxic tumor microenvironment, and strong therapeutic effects in PDX models. These findings establish 64Cu-ATSM PETx as a potential novel theranostic approach to facilitate local control of WHO CNS grade 4 HGGs.
BOT-3 GENOME-WIDE ASSOCIATION STUDY OF INTRACRANIAL GERM CELL TUMORS: A COMMON DELETION ATBAK1 ATTENUATES THE ENHANCER ACTIVITY AND CONFERS RISK FOR THE BRAIN TUMORS IN CHILDREN ADOLESCENTS AND YOUNG ADULTS
Authors: Terashima Keita , Sonehara Kyuto , Kimura Yui , Nakano Yoshiko , Ozawa Tatsuya , Takahashi Meiko , Suzuki Ken , Fujii Takashi , Matsushita Yuko , Tomiyama Arata , Suzuki Tomonari , Yamaguchi Shigeru , Miwa Tomoru , Sasaki Hikaru , Kitagawa Masashi , Ohe Naoyuki , Fukai Junya , Ogiwara Hideki , Kawamura Atsufumi , Miyawaki Satoru , Matsuda Fumihiko , Kiyakawa Nobutaka , Ichimura Koichi , Nishikawa Ryo , Okada Yukinori 
Published: December 2022

Abstract
Intracranial germ cell tumors (IGCTs) are rare brain tumors that mainly occur in children, adolescents and young adults with a particularly high incidence in East Asian populations. The biological basis of these tumors is still largely unknown. We conduct a genome-wide association study (GWAS) of 133 patients with IGCTs and 762 controls of Japanese ancestry by using Infinium Asian Screening Array and other molecular biology methods. A common 4-bp deletion polymorphism in an enhancer adjacent to BAK1 is significantly associated with the disease risk (rs3831846; P = 2.4 × 10−9, odds ratio = 2.46 [95% CI: 1.83-3.31], minor allele frequency = 0.43). Rs3831846 is in strong linkage disequilibrium with a testicular GCTs susceptibility variant rs210138. Expression quantitative trait locus (eQTL) analysis using the GTEx dataset reveals that the risk allele of rs3831846 has a down-regulating effect on BAK1 expression in a wide range of tissues. Further in-vitro reporter assays reveal rs3831846 to be a functional variant attenuating the enhancer activity. BAK1 is a pro-apoptotic member of the BCL-2 family, thus our results suggested that the risk allele may contribute to IGCTs predisposition through down-regulating BAK1 expression. Risk alleles of testicular GCTs derived from the European GWAS show significant positive correlations in the effect sizes with the Japanese IGCTs GWAS (P = 1.3 × 10-4, Spearman’s ρ = 0.48). Of the 57 loci, 11 exhibit significant association with IGCTs and these loci were implicated in a broad range of biological pathways, including KIT/KITLG signaling, apoptosis regulation, and telomerase activity. The risk allele frequency of rs3831846 is higher in east Asia than Europe (0.49 vs. 0.20), which may provide a partial explanation for the ethnic difference in incidence. Nevertheless, our results suggest the shared genetic susceptibility of GCTs beyond ethnicity and primary sites.