bluuebunny/crossref_metadata_2025_split huggingface dataset:
NVRAM as an Enabler to New Horizons in Graph Processing
Authors: Capelli Ludovic Anthony Richard , Brown Nicholas , Bull Jonathan Mark 
Published: July 2022

AbstractFrom the world wide web, to genomics, to traffic analysis, graphs are central to many scientific, engineering, and societal endeavours. Therefore an important question is what hardware technologies are most appropriate to invest in and use for processing graphs, whose sizes now frequently reach terabytes. Non-Volatile Random Access Memory (NVRAM) technology is an interesting candidate enabling organisations to extend the memory in their systems typically by an order of magnitude compared to Dynamic Read Access Memory (DRAM) alone. From a software perspective, it permits to store a much larger dataset within a single memory space and avoid the significant communication cost incurred when going off node. However, to obtain optimal performance one must consider carefully how best to integrate this technology with their code to cope with NVRAM esoteric properties such as asymmetric read/write performance or explicit coding for deeper memory hierarchies for instance. In this paper, we investigate the use of NVRAM in the context of shared memory graph processing via vertex-centric. We find that NVRAM enables the processing of exceptionally large graphs on a single node with good performance, price and power consumption. We also explore the techniques required to most appropriately exploit NVRAM for graph processing and, for the first time, demonstrate the ability to process a graph of 750 billion edges whilst staying within the memory of a single node. Whilst the vertex-centric graph processing methodology is our main focus, not least due to its popularity since introduced by Google over a decade ago, the lessons learnt in this paper apply more widely to graph processing in general.
Modeling of Ventilation’s Influence on Energy Consumption in Multi-cylinder Dryer Section Part1: Theoretical Model
Authors: Yin Yongjun , Liu Jiang , Wang Yang , Zhuo Yinru , Meng Yu 
Published: July 2022

AbstractVentilation system affects the water evaporation rate, energy consumption and the paper quality, which is considered as the largest optimization potential part of multi-cylinder dryer section. Energy consumption of drying system is divided into three parts: steam consumption of cylinders, steam consumption of air heaters, power consumption of blowers and exhaust fans. An energy consumption model of drying system integrating steam condensation system and ventilation system is constructed according to the control logic and process flow of the actual ventilation system, by combining the established models of each module and energy consumption indexes. It is the premise to realize the intelligent control of paper drying process. The research results perfects the mechanism of ventilation system for assisted drying, which can promote the improvement of the monitoring, and enable intelligent computing technology to play a greater role in optimizing drying operation and reducing drying energy consumption.
Vestibulodynia and the Vaginal Microbiome: A Case-Control Study
Authors: Panzarella Doreen A. , Peresleni Tatyana , Collier Jackie L. , Kocis Christina , Baker David A. 
Published: July 2022

ABSTRACT

Background
Recent studies of the vaginal microbiome have led to a better understanding of the microbiota and interactions with the host environment, however the role of the vaginal microbiome in vestibulodynia remains unclear.

Aim
This study aims to investigate and examine differences in the bacterial and fungal microbiome among patients with vestibulodynia and healthy controls.

Methods
A case-control study was conducted examining the vaginal microbiome of 29 patients with vestibulodynia and 26 controls through Stony Brook University Obstetrics and Gynecology ambulatory clinic. Exclusion criteria included a diagnosis of vaginal infection at the time of presentation, a prior diagnosis of vulvodynia or receipt of treatment, immunosuppression, and receipt of steroid or antibiotic therapy. Vaginal swab samples were obtained from participants. DNA was extracted and sent for diversity assay of 16S rRNA for prokaryotic species and internal transcribed spacers (ITS) for fungi. Demographic characteristics for both cases and controls were obtained through a retrospective chart review.

Outcome Measure
Principal component analysis (PCA) and linear discriminant analysis effect size (LefSe) were used to identify differences in relative abundance of operational taxonomic units (OTUs) for the vaginal microbiome between vestibulodynia patients and controls.

Results
Lactobacillus species were dominant amongst both cases and controls. PCA of 16S and ITS OTUs did not show significant differences in microbiome composition between vestibulodynia patients and controls. LefSe demonstrated higher abundance of Bifidobacterium longum, the Genus Sneathia, and the Family Leptotrichiaceae, in controls compared to vestibulodynia samples. For ITS, Aspergillus spp. was significantly more prevalent in controls than in vestibulodynia cases.

Clinical Implications
Additional studies are needed to further assess the clinical significance of these findings.

Strengths and Limitations
Strengths of this study include ITS amplicon sequence analysis for fungal species diversity. Limitations of this study include small sample size and lack of racial diversity.

Conclusions
Our study did not find significant differences in composition or diversity between the vaginal microbiomes of cases of vestibulodynia and controls; however, the data suggests differences in abundance of biota requiring further research for biological and clinical significance.
The relation of unrest-related distress with probable depression during and after widespread civil unrest
Authors: Tao Tiffany Junchen , Li Tsz Wai , Yim Sammi Sum Wai , Hou Wai Kai 
Published: July 2022

AbstractBackgroundThis study investigated whether subjective unrest-related distress was associated with probable depression during and after the 2019 anti-ELAB movement in Hong Kong.MethodsPopulation-representative data were collected from 7157 Hong Kong Chinese in four cross-sectional surveys (July 2019–July 2020). Logistic regression examined the association between subjective unrest-related distress and probable depression (PHQ-9 ⩾ 10), stratified by the number of conflicts/protests across the four timepoints.ResultsUnrest-related distress was positively associated with probable depression across different numbers of conflicts/protests.ConclusionUnrest-related distress is a core indicator of probable depression. Public health interventions should target at resolving the distress during seemingly peaceful period after unrest.
Late Palaeozoic tectonic evolution of the eastern Palaeo-Asian Ocean: new evidence from the early Permian arc magmatic suites in the Kulun region
Authors: Jing Yan , Ge Wen-chun , Yang Hao , Dong Yu , Ji Zheng , Bi Jun-hui , Zhou Hong-ying , Xing Dehe 
Published: July 2022

AbstractLate Palaeozoic igneous rock associations in response to subduction, accretion, and final closure of the eastern Palaeo-Asian Ocean play a significant role in understanding the geodynamic evolution of the southeastern Central Asian Orogenic Belt. Previous studies have identified a Permian arc magmatic belt associated with the southward-dipping subduction of the eastern Palaeo-Asian Ocean along the Solonker–Changchun suture zone. The genetic mechanism and associated geodynamic settings are of great importance in deciphering the evolution of the eastern Palaeo-Asian Ocean. This paper presents zircon U–Pb–Hf isotope and whole-rock geochemical analyses for a suite of magmatic rocks including the early Permian diorite porphyrites (ca. 281.0 Ma), andesites (ca. 276 Ma) and rhyolites (ca. 275 Ma) in the Kulun region. The diorite porphyrites and andesites have high SiO2and total alkali contents, and low MgO contents and Mg no. values, with enrichments in large ion lithophile elements and depletions in high-field-strength elements. These geochemical characteristics, together with low-Sr and high-Yb contents, a weak concave-upward shape of middle rare earth elements and negative Eu anomalies, suggest that these intermediate igneous rocks were generated by partial melting of amphibolitic lower crust at a crustal depth of 30–40 km. The rhyolites have heterogeneous isotopic compositions, withϵHf(t) values andTDM2ages of –20.8 to +0.5 and 3578∼1494 Ma, implying that they were likely derived from partial melting of a mixed source dominated by recycled ancient crust with minor juvenile crustal materials. The rhyolites show potassic affinity with relatively high K2O and very low Na2O, which was attributed to liquid immiscibility of felsic magma and subsequent limited fractional crystallization of plagioclase. The regional igneous associations, metamorphic events, and coeval sedimentary rocks along the Solonker–Changchun suture zone indicate that the early Permian igneous rocks were formed in an active continental arc environment in response to southward subduction of the eastern Palaeo-Asian Ocean.
Credit Default Swaps and Lender Incentives in Bank Debt Renegotiations
Authors: Chakraborty Indraneel , Chava Sudheer , Ganduri Rohan 
Published: July 2022

AbstractUsing a regression-discontinuity design and within lender–borrower variation, we analyze how credit default swaps (CDSs) affect bank incentives and borrower outcomes in renegotiations after covenant violations. While existing studies document an investment decline after covenant violations, we find that covenant-violating firms maintain their investment subsequent to the introduction of CDS trading. Moreover, after CDS introduction, covenant-violating firms are less likely to default. Our results suggest that in the private debt markets, CDSs discipline borrowers, while the empty creditor problem due to CDS is mitigated because of lenders’ reputation concerns and lower coordination frictions.
Molecular identification of trematode parasites infecting the freshwater snail Bithynia siamensis goniomphalos in Thailand
Authors: Pitaksakulrat O. , Sithithaworn P. , Kopolrat K.Y. , Kiatsopit N. , Saijuntha W. , Andrews R.H. , Petney T.N. , Blair D. 
Published: July 2022

Abstract
Digenetic trematodes are important parasites of humans and animals. They have complex life cycles and typically infect a gastropod as the first intermediate host. Bithynia siamensis goniomphalos, the first intermediate host of the liver fluke, Opisthorchis viverrini, harbours a wide variety of other trematode species. Morphological details of cercariae of 20 trematode taxa from B. s. goniomphalos, collected mainly in Thailand from 2009 to 2014, were provided in an earlier paper. Correct identification to the species or genus level based on morphology of these cercariae is generally not possible. Therefore, we used molecular data to improve identification and to investigate the diversity of the species of trematodes infecting B. s. goniomphalos. We were successful in extracting, amplifying and sequencing portions of the 28S ribosomal RNA (rRNA) gene for 19 of these 20 types of cercaria, and the internal transcribed spacer 2 region for 18 types. BLAST searches in GenBank and phylogenetic trees inferred from the 28S rRNA sequences identified members of at least nine superfamilies and 12 families. Only a few cercariae could be assigned confidently to genus or species on the basis of the sequence data. Matching sequence data from named adult trematodes will be required for definitive identification. There is clearly a great diversity of trematode species utilizing B. s. goniomphalos in Thailand.
A systematic review of relational-based therapies for the treatment of auditory hallucinations in patients with psychotic disorders
Authors: Dellazizzo Laura , Giguère Sabrina , Léveillé Nayla , Potvin Stéphane , Dumais Alexandre 
Published: July 2022

AbstractBackgroundAuditory hallucinations in patients with psychotic disorders may be very distressing. Unfortunately, a large proportion of individuals are resistant to pharmacological interventions and the gold-standard cognitive-behavioral therapy for psychosis offers at best modest effects. To improve therapeutic outcomes, several therapies have been created to establish a relationship between voice-hearers and their voices. With increasing literature, we conducted a systematic review of dialogical therapies and examined the evidence behind their efficacy.MethodsA systematic search was performed in PubMed, PsycINFO, Web of Science, and Google Scholar. Articles were included if they discussed the effects of dialogical interventions for patients with psychotic disorders.ResultsA total of 17 studies were included within this systematic review. Cumulative evidence from various therapies has shown that entering in a dialog with voices is beneficial to patients, even those who are resistant to current pharmacological treatments. Heightened benefits have been mainly observed with Relating Therapy and Avatar Therapy/Virtual Reality assisted Therapy, with evidence generally of moderate quality. Both these interventions have shown large to very large effects on voices and voice-related distress as well as moderate to large magnitude improvements on affective symptoms. Though, cognitive-behavioral therapy for command hallucinations and making sense of voices noted no improvements on voices.ConclusionsLiterature on relational-based interventions with a strong emphasis on the relational aspects of voice hearing has shown positive effects. Results suggest that these dialogical therapies might surpass the efficacy of current gold-standard approaches.
Southern Hemisphere Stratospheric Warmings and Coupling to the Mesosphere‐Lower Thermosphere
Authors: Vincent R. A. , Kovalam S. , Reid I. M. , Murphy D. J. , Klekociuk A. 
Published: July 2022

AbstractTwenty six years of medium frequency (MF) radar wind measurements made from 1994 to 2019 at Davis Station (68.6°S, 77.9°E) are used to study the mean response of the mesosphere‐lower thermosphere to stratospheric warmings in the Southern Hemisphere. Warming events were detected using Modern‐Era Retrospective Analysis for Research and Applications (MERRA2) data with a systematic search for reductions in the zonal‐mean circulation at 60°S and corresponding increases in polar temperatures. Some 37 events were identified, including the 2002 major warming and the large event of 2019, with an average of 1–2 warmings per year. At the 10 hPa level, the polar cap temperature increases ranged from 3 to 28 K, with a mean value of 12 K, while the zonal wind speed reductions varied between −6 and −43 ms−1, with a mean value of −15 ms−1. Peak values occurred near 40 km. Warmings occurred mainly between August and October, with a small peak in occurrence in April/May. The MF radar data showed an average reduction in the mesospheric eastward winds of about 5–7 ms−1 at heights near 75 km that occurred 3–4 days prior to the changes in the stratosphere. Warming events were driven by episodic intensifications in planetary wave amplitudes, with quasi‐stationary planetary scale waves (PW) 1 being especially important. PW Eliassen‐Palm flux divergences show a systematic behavior with time and height that is consistent with a poleward residual circulation and downwelling over the pole prior to the warming events and an equatorward flow and upwelling after the peak of the events.
The role of health-based food choice motives in explaining the relationship between lower socioeconomic position and higher BMI in UK and US adults
Authors: Robinson Eric , Jones Andrew , Marty Lucile 
Published: July 2022

Abstract
Background/Objectives
Lower socioeconomic position (SEP) is associated with increased risk of higher BMI and developing obesity. No research to date has directly examined whether SEP differences in health-based food choice motives or executive function explain why lower SEP is associated with higher BMI.

Subjects/Methods
We analysed observational data from large samples of UK (N = 4130) and US (N = 1898) adults which included measures of SEP (education level, household income and subjective social status) and self-reported BMI. Participants also completed validated self-report measures on the extent to which their day-to-day food choices were motivated by health and weight control, as well as completing computerized tasks measuring inhibitory control (Stroop task) and working memory (Digit span task).

Results
Across both UK and US adults, the relationship between indicators of lower SEP and higher BMI were consistently explained by participants from lower SEP backgrounds reporting being less motivated by health when making food choices, which accounted for 18–28% of the association between lower SEP and higher BMI. There was no evidence that measures of executive function explained associations between SEP and BMI or moderated relations between food choice motives and higher BMI.

Conclusions
SEP differences in health-based food choice motives may play an important role in explaining why lower SEP is associated with an increased risk of higher BMI.
Resistance evolution can disrupt antibiotic exposure protection through competitive exclusion of the protective species
Authors: Quinn Angus M , Bottery Michael J , Thompson Harry , Friman Ville-Petri 
Published: July 2022

Abstract
Antibiotic degrading bacteria can reduce the efficacy of drug treatments by providing antibiotic exposure protection to pathogens. While this has been demonstrated at the ecological timescale, it is unclear how exposure protection might alter and be affected by pathogen antibiotic resistance evolution. Here, we utilised a two-species model cystic fibrosis (CF) community where we evolved the bacterial pathogen Pseudomonas aeruginosa in a range of imipenem concentrations in the absence or presence of Stenotrophomonas maltophilia, which can detoxify the environment by hydrolysing β-lactam antibiotics. We found that P. aeruginosa quickly evolved resistance to imipenem via parallel loss of function mutations in the oprD porin gene. While the level of resistance did not differ between mono- and co-culture treatments, the presence of S. maltophilia increased the rate of imipenem resistance evolution in the four μg/ml imipenem concentration. Unexpectedly, imipenem resistance evolution coincided with the extinction of S. maltophilia due to increased production of pyocyanin, which was cytotoxic to S. maltophilia. Together, our results show that pathogen resistance evolution can disrupt antibiotic exposure protection due to competitive exclusion of the protective species. Such eco-evolutionary feedbacks may help explain changes in the relative abundance of bacterial species within CF communities despite intrinsic resistance to anti-pseudomonal drugs.
A descriptive cohort study of withdrawal from inhaled corticosteroids in COPD patients
Authors: Patel Smit , Dickinson Scott , Morris Kevin , Ashdown Helen F. , Chalmers James D. 
Published: July 2022

AbstractInhaled corticosteroid (ICS) therapy is widely prescribed without a history of exacerbations and consensus guidelines suggest withdrawal of ICS in these patients would reduce the risk of side effects and promote cost-effective prescribing. The study describes the prescribing behaviour in the United Kingdom (UK) in relation to ICS withdrawal and identifies clinical outcomes following withdrawal using primary and secondary care electronic health records between January 2012 and December 2017. Patients with a history ≥12 months’ exposure who withdrew ICS for ≥6 months were identified into two cohorts; those prescribed a long-acting bronchodilator maintenance therapy and those that were not prescribed any maintenance therapy. The duration of withdrawal, predictors of restarting ICS, and clinical outcomes were compared between both patient cohorts. Among 76,808 patients that had ≥1 prescription of ICS in the study period, 11,093 patients (14%) withdrew ICS therapy at least once during the study period. The median time without ICS was 9 months (IQR 7–14), with the majority (71%) receiving subsequent ICS prescriptions after withdrawal. Patients receiving maintenance therapy with a COPD review at withdrawal were 28% less likely to restart ICS (HR: 0.72, 95% CI 0.61, 0.85). Overall, 69% and 89% of patients that withdrew ICS had no recorded exacerbation event or COPD hospitalisation, respectively, during the withdrawal. This study provides evidence that most patients withdrawing from ICS do not experience COPD exacerbations and withdrawal success can be achieved by carefully planning routine COPD reviews whilst optimising the use of available maintenance therapies.
SANA: cross-species prediction of Gene Ontology GO annotations via topological network alignment
Authors: Wang Siyue , Atkinson Giles R. S. , Hayes Wayne B. 
Published: July 2022

AbstractTopological network alignment aims to align two networks node-wise in order to maximize the observed common connection (edge) topology between them. The topological alignment of two protein–protein interaction (PPI) networks should thus expose protein pairs with similar interaction partners allowing, for example, the prediction of common Gene Ontology (GO) terms. Unfortunately, no network alignment algorithm based on topology alone has been able to achieve this aim, though those that include sequence similarity have seen some success. We argue that this failure of topology alone is due to the sparsity and incompleteness of the PPI network data of almost all species, which provides the network topology with a small signal-to-noise ratio that is effectively swamped when sequence information is added to the mix. Here we show that the weak signal can be detected using multiple stochastic samples of “good” topological network alignments, which allows us to observe regions of the two networks that are robustly aligned across multiple samples. The resulting network alignment frequency (NAF) strongly correlates with GO-based Resnik semantic similarity and enables the first successful cross-species predictions of GO terms based on topology-only network alignments. Our best predictions have an AUPR of about 0.4, which is competitive with state-of-the-art algorithms, even when there is no observable sequence similarity and no known homology relationship. While our results provide only a “proof of concept” on existing network data, we hypothesize that predicting GO terms from topology-only network alignments will become increasingly practical as the volume and quality of PPI network data increase.