bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the prevalence of disordered eating in a cohort of young Australians presenting for mental health care at a headspace centre: results from a cross-sectional clinical survey study
Authors: Burton Amy Leigh , Hamilton Blake , Iorfino Frank , La Monica Haley M , Scott Elizabeth M , Hickie Ian B 
Published: August 2022

ObjectivesThe aim of this study was to determine the prevalence of disordered eating in young people attending a headspace centre, an enhanced primary care centre providing early intervention services for mental health disorders for young people aged 12–25 years, in metropolitan Sydney.DesignCross-sectional assessment of disordered eating symptoms and behaviours.SettingAn enhanced primary care youth mental health service in inner urban Sydney, Australia.ParticipantsA sequential cohort of 530 young people aged 14–26 years presenting to headspace Camperdown for support with mental health concerns.Outcome measuresParticipants completed a series of questionnaires online which included items assessing the presence of eating disorder symptoms and behaviours.ResultsOver one-third of young people aged 14–26 years presenting to headspace Camperdown in a 22-month period reported symptoms of disordered eating. Of these, 32% endorsed overeating behaviours, 25% endorsed dietary restriction and 8% reported purging behaviours. In total, 44% reported engaging in one of more of these behaviours on a regular basis. Almost half reported experiencing significant shape and weight concerns. Eating disorder behaviours were particularly prevalent among female and gender-diverse participants (48% of females and 46% of gender-diverse participants compared with 35% of males) and overall scores across all of the eating disorder and body image items assessed were significantly higher for female participants compared with males.ConclusionsDisordered eating behaviours and symptoms are common among those presenting to youth mental health primary care services. Proactive screening for these behaviours presents opportunities for early detection and specific interventions.Trial registration numberACTRN12618001676202; Results.
Using historical cardiac troponins to identify patients at a high risk of myocardial infarction
Authors: Roos Andreas , Edgren Gustaf 
Published: August 2022

ObjectiveMany patients who present with chest pain have previous measurements of high-sensitivity cardiac troponin T (hs-cTnT). The clinical usefulness of incorporating these measurements in identifying patients who are at a high risk of myocardial infarction (MI) is unknown. We investigated if the relative change between a historical hs-cTnT and the admission hs-cTnT could improve early identification of patients with a high risk of MI.MethodsWe included all patients presenting with chest pain to seven different emergency departments (EDs) in Sweden from December 2009 to December 2016, who had at least one hs-cTnT measurement at the presentation and at least one available prior measurement. We used logistic regression to investigate the diagnostic performance of using various combinations of current and historical hs-cTnT measurements in diagnosing MI within 30 days.ResultsA total of 27 809 visits were included, among whom 2686 (9.7%) had an MI within 30 days. A cut-off value for historical hs-cTnT-adjusted admission hs-cTnT with similar specificity (91.2%) as an admission hs-cTnT of ≥52 ng/L identified 4% more MIs (43% vs 39%) and had a higher positive predictive value, 42.6% (95% CI, 41.0% to 44.3%) vs 38.9% (95% CI 37.4% to 40.4%), as well as a higher positive likelihood ratio, 6.95 (95% CI 6.69 to 7.22) vs 5.95 (95% CI 5.73 to 6.18). Among patients with an admission hs-cTnT of <52 ng/L who were classified as high-risk patients when incorporating past hs-cTnT measurements, 28% suffered an MI.ConclusionsHistorical hs-cTnT levels can be used with admission hs-cTnT to improve early risk stratification of MI in the ED.
Rationale and design of a randomised trial of intravenous iron in patients with heart failure
Authors: Kalra Paul R , Cleland John GF , Petrie Mark C , Ahmed Fozia Z , Foley Paul WX , Kalra Philip A , Lang Ninian N , Lane Rebecca E , Macdougall Iain C , Pellicori Pierpaolo , Pope Michael T B , Robertson Michele , Squire Iain B , Thomson Elizabeth A , Ford Ian 
Published: August 2022

ObjectivesFor patients with a reduced left ventricular ejection fraction (LVEF) heart failure with reduced ejection fraction (HFrEF) and iron deficiency, administration of intravenous iron improves symptoms, exercise capacity and may in the following 12 months, reduce hospitalisations for heart failure. The Effectiveness ofIntravenous irontreatment versus standard care in patients with heart failure and iron deficiency (IRONMAN) trial evaluated whether the benefits of intravenous iron persist in the longer term and impact on morbidity and mortality.MethodsIRONMAN is a prospective, randomised, open-label, blinded endpoint (PROBE) event-driven trial. Patients aged ≥18 years with HFrEF (LVEF ≤45%) and evidence of iron deficiency (ferritin <100 µg/L and/or TSAT <20%) were enrolled if they had either a current or recent hospitalisation for heart failure or elevated plasma concentrations of a natriuretic peptide. Participants were randomised to receive, or not to receive, intravenous ferric derisomaltose in addition to guideline-recommended therapy for HFrEF. Every 4 months, intravenous iron was administered if either ferritin was <100 µg/L or, provided ferritin was ≤400 µg/L, TSAT was <25%. The primary endpoint is a composite of total hospitalisations for heart failure and cardiovascular death. Hospitalisation and deaths due to infection are safety endpoints.ResultsTrial recruitment was completed across 70 UK hospital sites in October 2021. Participants were followed until the end of March 2022. We plan to report the results by November 2022.ConclusionsIRONMAN will determine whether repeated doses of intravenous ferric derisomaltose are beneficial and safe for the long-term treatment of a broad range of patients with HFrEF and iron deficiency.Trial registration numberNCT02642562.
Shadows and thin accretion disk images of the $$\gamma $$-metric
Authors: Shaikh Rajibul , Paul Suvankar , Banerjee Pritam , Sarkar Tapobrata 
Published: August 2022

AbstractThe $$\gamma $$
γ
-metric is a static, axially-symmetric singular solution of the vacuum Einstein’s equations without an event horizon. This is a two-parameter family of solutions, generic values of one of which (called $$\gamma $$
γ
) measure the deviation from spherical symmetry. We show that this can serve as a black hole mimicker, consistent with current observations. To this end, we first study the shadow cast by this geometry, in order to constrain the $$\gamma $$
γ
-metric from observations. We find that for $$\gamma < 1/2$$

γ
<
1
/
2

, there are, in principle, no shadows cast. On the other hand, shadows cast for all values of $$\gamma \ge 1/2$$

γ
≥
1
/
2

are consistent with observations of M$$87^*$$

87
∗

by the Event Horizon Telescope. We also study images of thin accretion disks in the $$\gamma $$
γ
-metric background. In situations where the $$\gamma $$
γ
-metric possesses light rings, these qualitatively mimic Schwarzschild black holes with the same ADM mass, while in the absence of such rings, they are drastically different from the black hole case.
HANDS ACTIVITY LEVEL AND UPPER EXTREMITY WORK-RELATED MUSCULOSKELETAL DISORDERS IN FEMALE CARPET WEAVERS: A MATCHED CASE-CONTROL STUDY
Authors: Jalali Mahdi , Fazeli Seyyed Poorya , Ebrahemzadih Mehrzad , Zakeri Hamid Reza , Rahimimoghadam Somayeh , Mojiri Samane Abd 
Published: August 2022

Introduction: Carpet weaving is one of the most common occupations in Iran. Studies have shown that the majority of workers in these industries are women and these people are exposed to high occupational risks such as musculoskeletal disorders (MSDs). This study aimed to evaluate the hands activity level and upper extremity work-related musculoskeletal disorders (UEWMSDs) symptoms in female carpet weavers (FCWs). Methods: This case-control observational study was performed on 150 FCWs of a carpet weaving workshop as a case group and 150 office staff as a control group. In order to assess the risk factors for UEWMSDs, the Hand Activity Level-Threshold Limit Value (HAL-TLV) method was used. The Cornell Musculoskeletal Discomfort Questionnaire (CMDQ) was used to assess the prevalence of UEWMSDs symptoms in the past year. Data were analyzed using SPSS-V 24. Results: The mean final scores of the HAL_TLV for the case and control groups were 1.04 and 0.15, respectively. The results of the statistical analysis showed a statistical significant difference between the mean of HAL, NPF, and HAL_TLV variables in case and control groups ([Formula: see text] [Formula: see text] 0.001). Also, the results showed a statistical significant difference between the mean scores of the incidence of discomfort in the Shoulder, Forearm, and Wrist areas in the case and control groups ([Formula: see text] [Formula: see text] 0.001). Conclusion: The results of this study show the effect of increasing the level of hand activity on UEWMSDs symptoms. To reduce the level of hand activity and UEWMSDs symptoms in FCWs, there should be increased focus on work time, work speed, and the use of ergonomic, lightweight hand tools.
Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation of p53 Function
Authors: Macha Shawn J. , Koneru Balakrishna , Burrow Trevor A. , Zhu Charles , Savitski Dzmitry , Rahman Rakhshanda L. , Ronaghan Catherine A. , Nance Jonas , McCoy Kristyn , Eslinger Cody , Reynolds C. Patrick 
Published: August 2022

Abstract

A subset of cancers across multiple histologies with predominantly poor outcomes use the alternative lengthening of telomeres (ALT) mechanism to maintain telomere length, which can be identified with robust biomarkers. ALT has been reported to be prevalent in high-risk neuroblastoma and certain sarcomas, and ALT cancers are a major clinical challenge that lack targeted therapeutic approaches. Here, we found ALT in a variety of pediatric and adult cancer histologies, including carcinomas. Patient-derived ALT cancer cell lines from neuroblastomas, sarcomas, and carcinomas were hypersensitive to the p53 reactivator eprenetapopt (APR-246) relative to telomerase-positive (TA+) models. Constitutive telomere damage signaling in ALT cells activated ataxia-telangiectasia mutated (ATM) kinase to phosphorylate p53, which resulted in selective ALT sensitivity to APR-246. Treatment with APR-246 combined with irinotecan achieved complete responses in mice xenografted with ALT neuroblastoma, rhabdomyosarcoma, and breast cancer and delayed tumor growth in ALT colon cancer xenografts, while the combination had limited efficacy in TA+ tumor models. A large number of adult and pediatric cancers present with the ALT phenotype, which confers a uniquely high sensitivity to reactivation of p53. These data support clinical evaluation of a combinatorial approach using APR-246 and irinotecan in ALT patients with cancer.

Significance:
This work demonstrates that constitutive activation of ATM in chemotherapy-refractory ALT cancer cells renders them hypersensitive to reactivation of p53 function by APR-246, indicating a potential strategy to overcome therapeutic resistance.
The application of phosphor Sr4La(PO4)3O:Ce3+,Tb3+,Mn2+ on the white-LEDs: luminescence and power transmission characteristics
Authors: Nguyen Thi My Hanh , Xuan Le Phan 
Published: August 2022

<span lang="EN-GB">Using a high temperature solid-state technique, various phosphors Sr<sub>4</sub>La(PO<sub>4</sub>)<sub>3</sub>O:Ce<sup>3+</sup>, Tb<sup>3+</sup>,Mn<sup>2+</sup> (SLPO:Ce,Tb,Mn) were produced. In Sr<sub>4</sub>La(PO<sub>4</sub>)<sub>3</sub>O, the luminescence characteristics, thermal stability, and energy conversion between Ce<sup>3+ </sup>and Tb<sup>3+</sup>-Mn<sup>2+ </sup>have been thoroughly studied. The sensitizer Ce<sup>3+</sup> particles inclusion could considerably improve the feeble Tb<sup>3+</sup> green radiation and Mn<sup>2+</sup> red radiation via energy transfer. By adjusting the scale of Ce<sup>3+</sup>/Tb<sup>3+</sup> over Ce<sup>3+</sup>/Mn<sup>2+</sup> atoms, the color of the emission may be changed. White light was produced in the Sr<sub>4</sub>La(PO<sub>4</sub>)<sub>3</sub>O:0.12Ce<sup>3+</sup>,0.3Mn<sup>2+</sup> specimen with chromatism coordinates of (0.3326, 0.3298), showing that the phosphors SLPO:Ce,Tb,Mn possess promising application on WLEDs. The conclusion is supported by Mie-scattering theory and Lambert-Beer's law.</span>
Synthesis and photoluminescence properties in white light-emitting diodes of oxynitride green phosphor Ba3Si6O12N2
Authors: Nguyen Thi Dieu An , Xuan Le Phan 
Published: August 2022

<span>Utilizing boron-coated Eu<sub>2</sub>O<sub>3</sub>, highly effective Ba<sub>3</sub>Si<sub>6</sub>O<sub>12</sub>N<sub>2</sub> green-emitting phosphors were made using a gas reduction nitridation technique under flowing NH<sub>3</sub> gas. We found that the synthesized phosphor is a pure phase of Ba<sub>3</sub>Si<sub>6</sub>O<sub>12</sub>N<sub>2</sub> based on X-ray diffraction patterns. By modifying an alumina boat crystallized, the Ba<sub>3</sub>Si<sub>6</sub>O<sub>12</sub>N<sub>2</sub> green-emitting phosphors from the result were considerably better and had higher emission intensity. Under stimulation at 405 nm, the radiation spectra revealed a typical wide green radiation band attributable to the 4f<sup>6</sup>5d → 4f<sup>7</sup> electronic transfer of Eu<sup>2+</sup> ions. Generally, the green-emitting Ba<sub>3</sub>Si<sub>6</sub>O<sub>12</sub>N<sub>2</sub> phosphors that were created by that method with boron-coated Eu<sub>2</sub>O<sub>3</sub> is a potential phosphor-transformed diodes which emit white illumination white light emitting diodes(pc-WLEDs') element.</span>
A Ppreliminary study on the intelligent model of k-nearest neighbor for agarwood oil quality grading
Authors: Huzir Siti Mariatul Hazwa Mohd , Mahabob Noratikah Zawani , Amidon Aqib Fawwaz Mohd , Ismail Nurlaila , Yusoff Zakiah Mohd , Taib Mohd Nasir 
Published: August 2022

Essential <span>oils extracted from trees has various usages like perfumes, incense, aromatherapy and traditional medicine which increase their popularity in global market. In Malaysia, the recognition system for identifying the essential oil quality still does not reach its standard since mostly graded by using human sensory evaluation. However, previous researchers discovered new modern techniques to present the quality of essential oils by analyse the chemical compounds. Agarwood essential oil had been chosen for the proposed integrated intelligent models with the implementation of k-nearest neighbor (k-NN) due to the high demand and an expensive natural raw world resource. k-NN with Euclidean distance metrics had better performance in terms of its confusion matrix, sensitivity, precision accuracy and specificity. This paper presents an overview of essential oils as well as their previous analysis technique. The review on k-NN is done to prove the technique is compatible for future research studies based on its performance.</span>
Development of a mobile expert system for the diagnosis on motorcycle damage using forward chaining algorithm
Authors: Fitri Naryanto Rizqi , Delimayanti Mera Kartika , Kriswanto Kriswanto , Musyono Ari Dwi Nur Indriawan , Sukoco Imam , Aditya Mohamad Naufal 
Published: August 2022

Indonesia is an <span>ASEAN country with the most motorcycle users, where one-third of its population own motorcycles. The automatic motorcycle is the most widely used type due to its agility and fuel-efficient abilities. Sudden motorcycle damage could hamper the users' activities. However, most of these users do not know the reason for the damage. This paper presents the development of expert system for diagnosing the damage of motorcycle using forward chaining method. This system was implemented in mobile application. Through a mobile application, a solution for these users can be obtained. This application immediately discovers the damaged location and repair process. Furthermore, it acts as the first solution before motorcycle repair is carried out in a shop. In this study, the forward chaining method was implemented. It is based on a pattern-matching algorithm whose primary objective is to match facts (input data) with appropriate rules from the rule base. Various test results showed that the diagnostic application used for automatic motorcycle damages 100% worked.</span>
Puzzle optimization algorithm with capsule networks based Telugu character recognition model
Authors: Siva Phaniram Josyula , Babu Reddy Mukkamalla 
Published: August 2022

Recently, <span>Telugu character recognition (TCR) becomes a hot research topic because of drastic increase in technological advancements such as multimedia, and smartphones. Though numerous works have been concentrated on offline TCR models, it is still needed to develop automated and intelligent online TCR models. This paper presents a novel puzzle optimization algorithm with capsule networks-based Telugu character recognition (POACN-TCR) model. The presented POACN-TCR model intends to effectively identify and recognize distinct Telugu characters online. To accomplish this, the POACN-TCR model primarily undergoes pre-processing in different ways such as normalization, smoothing, and interpolation. In addition, the POACN-TCR model designs an effective capsule network (CapsNet) model to generate feature vectors and hyperparameter optimization takes place using puzzle optimization algorithm (POA). Finally, the C4.5 decision tree classifier is utilized for the effectual recognition of Telugu characters. The utilization of POA for hyperparameter optimization of the CapsNet model helps in achieving improved recognition performance. For ensuring the enhanced outcomes of the POACN-TCR model, a wide-ranging experimental analysis is performed and the outcomes pointed out the betterment of the POACN-TCR model on the recent approaches.</span>
Association of Blood Pressure–Related Increase in Vascular Stiffness on Other Measures of Target Organ Damage in Youth
Authors: Haley Jessica E. , Woodly Shalayna A. , Daniels Stephen R. , Falkner Bonita , Ferguson Michael A. , Flynn Joseph T. , Hanevold Coral D. , Hooper Stephen R. , Ingelfinger Julie R. , Khoury Philip R. , Lande Marc B. , Martin Lisa J. , Meyers Kevin E. , Mitsnefes Mark , Becker Richard C. , Rosner Bernard A. , Samuels Joshua , Tran Andrew H. , Urbina Elaine M. 
Published: August 2022

Background:
Hypertension-related increased arterial stiffness predicts development of target organ damage (TOD) and cardiovascular disease. We hypothesized that blood pressure (BP)–related increased arterial stiffness is present in youth with elevated BP and is associated with TOD.

Methods:
Participants were stratified by systolic BP into low-
(systolic BP <75th percentile, n=155), mid- (systolic BP ≥80th and <90th percentile, n=88), and high-risk BP categories (≥90th percentile, n=139), based on age-, sex- and height-specific pediatric BP cut points. Clinic BP, 24-hour ambulatory BP monitoring, anthropometrics, and laboratory data were obtained. Arterial stiffness measures included carotid-femoral pulse wave velocity and aortic stiffness. Left ventricular mass index, left ventricular systolic and diastolic function, and urine albumin/creatinine were collected. ANOVA with Bonferroni correction was used to evaluate differences in cardiovascular risk factors, pulse wave velocity, and cardiac function across groups. General linear models were used to examine factors associated with arterial stiffness and to determine whether arterial stiffness is associated with TOD after accounting for BP.

Results:
Pulse wave velocity increased across groups. Aortic distensibility, distensibility coefficient, and compliance were greater in low than in the mid or high group. Significant determinants of arterial stiffness were sex, age, adiposity, BP, and LDL (low-density lipoprotein) cholesterol. Pulse wave velocity and aortic compliance were significantly associated with TOD (systolic and diastolic cardiac function and urine albumin/creatinine ratio) after controlling for BP.

Conclusions:
Higher arterial stiffness is associated with elevated BP and TOD in youth emphasizing the need for primary prevention of cardiovascular disease.
Increased Risk of Preeclampsia in Women With a Genetic Predisposition to Elevated Blood Pressure
Authors: Kivioja Anna , Toivonen Elli , Tyrmi Jaakko , Ruotsalainen Sanni , Ripatti Samuli , Huhtala Heini , Jääskeläinen Tiina , Heinonen Seppo , Kajantie Eero , Kere Juha , Kivinen Katja , Pouta Anneli , Saarela Tanja , Laivuori Hannele 
Published: August 2022

Background:
Preeclampsia causes significant maternal and perinatal morbidity. Genetic factors seem to affect the onset of the disease. We aimed to investigate whether the polygenic risk score for blood pressure (BP; BP-PRS) is associated with preeclampsia, its subtypes, and BP values during pregnancy.

Methods:
The analyses were performed in the FINNPEC study (Finnish Genetics of Pre-Eclampsia Consortium) cohort of 1514 preeclamptic and 983 control women. In a case-control setting, the data were divided into percentiles to compare women with high BP-PRS (HBP-PRS; >95th percentile) or low BP-PRS (≤5th percentile) to others. Furthermore, to evaluate the effect of BP-PRS on BP, we studied 3 cohorts: women with preeclampsia, hypertensive controls, and normotensive controls.

Results:

BP values were higher in women with HBP-PRS throughout the pregnancy. Preeclampsia was more common in women with HBP-PRS compared with others (71.8% and 60.1%, respectively;
P
=0.009), and women with low BP-PRS presented with preeclampsia less frequently than others (44.8% and 61.5%, respectively;
P
<0.001). HBP-PRS was associated with an increased risk for preeclampsia (odds ratio, 1.7 [95% CI, 1.1–2.5]). Furthermore, women with HBP-PRS presented with recurrent preeclampsia and preeclampsia with severe features more often.

Conclusions:
Our results suggest that HBP-PRS is associated with an increased risk of preeclampsia, recurrent preeclampsia, and preeclampsia with severe features. Furthermore, women with HBP-PRS present higher BP values during pregnancy. The results strengthen the evidence pointing toward the role of genetic variants associated with BP regulation in the etiology of preeclampsia, especially its more severe forms.