bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular and morphological characterization of Digenea (Rhodomelaceae, Rhodophyta) in the Mexican Atlantic
Authors: Vilchis Martha Isabel , Hernández Oscar E. , Sentíes Abel , Dreckmann Kurt M. , Núñez Resendiz María Luisa , Ortegón-Aznar Ileana 
Published: October 2022

Abstract

Digenea is a widely distributed genus in the Mexican Atlantic, and until a few years ago the only morphospecies D. simplex was recorded. Recent molecular research on this species from a locality in the Mexican Caribbean revealed the new species D. mexicana, whose morphological similarity with specimens from Gulf of Mexico suggests that its distribution range could extend to this area. The aim of this work was to characterize the molecular and morphological characters of Digenea specimens from different sites in the Mexican Atlantic, to confirm this hypothesis and even reveal the presence of new species or records for the country. Our phylogenetic analysis of COI-5P and rbcL markers revealed a new record of D. arenahauriens in Mexico and confirm the presence of D. mexicana in the southern Gulf of Mexico. The species delimitation methods showed potential new species for Australia, Japan, and Brazil. The true D. simplex was not recorded molecularly for Mexico. Morphological comparisons indicated an overlap among most of the species of the genus. Future studies about molecular and morphological characterization of Digenea specimens from around the world could help to clarify the problem of specific delimitation, and even reveal new species for the genus.
Painting, Interpretation, Education: Tables of Knowledge in theImaginesof Philostratus the Athenian
Authors: Bakke Jørgen 
Published: October 2022

AbstractThis article shows how the descriptions of paintings (Imagines) by the ancient Greek author Philostratus (third century AD) can be viewed as pedagogical tools in the introduction to higher education. Philostratus presented his descriptions in the context of a tour in a picture gallery for young students. In the study presented here, the pedagogical context is taken seriously. With the means of three examples, the study shows how Philostratus uses his descriptions to guide his students into the interpretation of paintings, agriculture, and astronomy. Rather than simply present exemplary rhetorical descriptions of paintings as one would expect a rhetorical teacher to do, Philostratus uses paintings as pedagogical working tables where students can view simplified versions of complex fields of knowledge, an approach that is not unlike the visual presentation of introductory knowledge on old-fashioned cardboard wallcharts in modern schools.
Development of a new rotating photocatalytic reactor for the degradation of hazardous pollutants
Authors: Zelić Ivana Elizabeta , Tomašić Vesna , Gomzi Zoran 
Published: October 2022

Abstract
The aim of this study was to develop a new rotating photocatalytic reactor operating in recirculation mode with light sources placed outside the photoreactor vessel. The photoreactor with cylindrical geometry was equipped with four artificial lamps used to simulate solar irradiation (2.4% UVB and 12% UVA; 300–700 nm). The photocatalyst was immobilized on abrasive material used as a support and placed on the central (inner) photoreactor tube, which was connected to a power-driven shaft that allowed rotation at a desired speed. A suitable modification of the commercial TiO2 P25 photocatalyst was carried out to reduce its band gap energy and electron-hole recombination and to extend the visible light response range of TiO2. The main task of this research was to apply the basic principles of process intensification methodology, i.e. to explore the influence of rotational hydrodynamics, which allows good access of reactants to the photocatalyst surface, good irradiation of the photocatalytic surface and reduction of mass transfer resistance, leading to increased process efficiency. The homemade photoreactor was used for the photocatalytic degradation of one of the major types of neonicotinoid insecticides, acetamiprid. The influence of various working conditions, such as initial solution pH, rotation speed, recirculation flow rate and initial concentration of acetamiprid on the photocatalytic degradation process was investigated. The optimum degradation conditions were found at a recirculation flow rate of 200 cm3 min−1 and a rotation speed of 200 rpm, indicating that the mass transfer process strongly contributes to the photocatalytic degradation rate at the conditions used in this study. The results obtained during the photocatalytic degradation of acetamiprid in a rotating photoreactor were compared with those obtained under similar operating conditions in a flat-plate photoreactor, and the corresponding conclusions were drawn based on the performed kinetic analysis.
Relating agent prominence to discourse prominence: DO-clefts in German
Authors: Primus Beatrice , Kretzschmar Franziska , von Heusinger Klaus , Himmelmann Nikolaus P. 
Published: October 2022

Abstract
The article investigates the hypothesis that prominence phenomena on different levels of linguistic structure are systematically related to each other. More specifically, it is hypothesized that prominence relations in morphosyntax reflect, and contribute to, prominence management in discourse. This hypothesis is empirically based on the phenomenon of agentivity clines, i.e. the observation that the relevance of agentivity features such as volition or sentience is variable across different constructions. While some constructions, including German DO-clefts, show a strong preference for highly agentive verbs, other constructions, including German basic active constructions, have no particular requirements regarding the agentivity of the verb, except that at least one agentivity feature should be present. Our hypothesis predicts that this variable relevance of agentivity features is related to the discourse constraints on the felicitous use of a given construction, which in turn, of course, requires an explicit statement of such constraints. We propose an original account of the discourse constraints on DO-clefts in German using the ‘Question Under Discussion’ framework. Here, we hypothesize that DO-clefts render prominent one implicit question from a set of alternative questions available at a particular point in the developing discourse. This then yields a prominent question-answer pair that changes the thematic structure of the discourse. We conclude with some observations on the possibility of relating morphosyntactic prominence (high agentivity) to discourse prominence (making a Question Under Discussion prominent by way of clefting).
The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients
Authors: Su Li-ping , Ji Min , Liu Li , Sang Wei , Xue Jing , Wang Bo , Pu Hong-Wei , Zhang Wei 
Published: October 2022

Abstract

ASAP3 is involved in a variety of biological activities, including cancer progression in humans. In adult glioma, we explore the effects of ASAP3 and NOTCH3 and their relationships on prognosis. The Oncomine, TIMER, and Gene Expression Profiling Interactive Analysis databases were used to investigate ASAP3 expression. Immunohistochemistry was used to assess the levels of ASAP3 and NOTCH3 expressions. The effects of ASAP3 and NOTCH3 on prognosis were assessed using survival analysis. The results revealed that the amount of ASAP3 mRNA in gliomas was much higher than in normal tissue (P < 0.01). Glioma patients with high ASAP3 mRNA expression had a worse overall survival and progression-free survival. ASAP3 overexpression is directly associated with the NOTCH signaling system. Immunohistochemistry revealed that ASAP3 and NOTCH3 were overexpressed in glioblastomas (GBMs). ASAP3 expression was associated with age, recurrence, tumor resection, postoperative chemoradiotherapy, World Health Organization (WHO) grade, and Ki-67 expression. ASAP3 expression was related to the isocitrate dehydrogenase-1 mutation in low-grade glioma. Gender, local recurrence, tumor resection, postoperative radio-chemotherapy, WHO grade, recurrence, and ATRX expression were all associated with NOTCH3 expression. ASAP3 was shown to be positively associated with NOTCH3 (r = 0.337, P = 0.000). Therefore, ASAP3 and NOTCH3 as oncogene factors have the potential to be prognostic biomarkers and therapeutic targets in adult glioma.
Phaedrus und Martial: Zur Interaktion von Versfabel und Epigrammatik
Authors: Neger Margot 
Published: October 2022

AbstractThe influence of Phaedrus the fabulist on Martial the epigrammatist has long been neglected by scholarship. Quite recently scholars have started to pay more attention to Phaedrus’ literary techniques and allusive art, thus also paving the way for a reassessment of the role which Phaedrus played as a model for Martial. This paper examines the question to what extent the Flavian epigrammatist was inspired by Phaedrus’ literary techniques and argues that Phaedrus served as an important link in the process of the reception of Neoteric and Augustan poetry. Although there are not many thematic parallels between Phaedrus and Martial, the later poet seems to have been inspired considerably by Phaedrus’ metapoetic techniques. Furthermore, the paper also investigates the epigrammatic potential of Phaedrus’ own poems, a potential which seems to have made the fabulist especially attractive as a model for Martial.
Directional dependence of the plasmonic gain and nonreciprocity in drift-current biased graphene
Authors: Morgado Tiago A. , Silveirinha Mário G. 
Published: October 2022

Abstract
Here, we investigate the nonreciprocal propagation and amplification of surface plasmons in drift-current biased graphene, using both Galilean and relativistic-type Doppler shift transformations of the graphene’s conductivity. Consistent with previous studies, both conductivity models predict strongly nonreciprocal propagation of surface plasmons due to the drag effect caused by the drifting electrons. In particular, the Galilean Doppler shift model leads to stronger spectral asymmetries in the plasmon dispersion with regimes of unidirectional propagation. Remarkably, it is shown that both conductivity models predict regimes of nonreciprocal plasmon amplification in a wide angular sector of in-plane directions when the drift-current biased graphene sheet is coupled to a plasmonic substrate (namely, SiC), with the plasmon amplification rate being substantially higher for the relativistic Doppler shift model.
Fish Processing in the Iron Gates Region During the Transitional and Early Neolithic Period: An Integrated Approach
Authors: Petrović Anđa , Lemorini Cristina , Cesaro Stella Nunziante , Živaljević Ivana 
Published: October 2022

Abstract
It is well known that many Mesolithic and Early Neolithic sites were uncovered during the past century in the Iron Gates region of the North-Central Balkans. The application of diverse analyses on the bioarchaeological remains and artefacts raised many questions, but also offered new ideas about the Mesolithic–Neolithic transitional period in the Middle and Lower course of the Danube. Communities in the Iron Gates consumed fish and exploited the riverbank in prehistory. The stable isotope analyses are implying that these human groups fed on aquatic resources in some periods more than others. Fish remains were also found in settlements, and based on fish-related imagery on sculpted boulders and other artefacts, the bond between the people, river, and the ecosystem was compelling. The idea of this article is to present the possible ways of fish processing at Lepenski Vir using chipped stone tools. Three integrated methodologies, with high levels of interpretation, were applied: use-wear, residue, and archaeozoological analyses. Use-wear and residue analyses were performed on both archaeological and experimental chipped stone tools. The results are considered together with the traces of butchery observed on archaeological samples of fish bones, creating a more coherent picture of the everyday habits of the Iron Gates populations.
Columnar Lesions in Barrel Cortex Persistently Degrade Object Location Discrimination Performance
Authors: Ryan Lauren , Laughton Maya , Sun-Yan Andrew , Costello Samantha , Pancholi Ravi , Peron Simon 
Published: October 2022

AbstractPrimary sensory cortices display functional topography, suggesting that even small cortical volumes may underpin perception of specific stimuli. Traditional loss-of-function approaches have a relatively large radius of effect (>1 mm), and few studies track recovery following loss-of-function perturbations. Consequently, the behavioral necessity of smaller cortical volumes remains unclear. In the mouse primary vibrissal somatosensory cortex (vS1), “barrels” with a radius of ∼150 μm receive input predominantly from a single whisker, partitioning vS1 into a topographic map of well defined columns. Here, we train animals implanted with a cranial window over vS1 to perform single-whisker perceptual tasks. We then use high-power laser exposure centered on the barrel representing the spared whisker to produce lesions with a typical volume of one to two barrels. These columnar-scale lesions impair performance in an object location discrimination task for multiple days without disrupting vibrissal kinematics. Animals with degraded location discrimination performance can immediately perform a whisker touch detection task with high accuracy. Animals trainedde novoon both simple and complex whisker touch detection tasks showed no permanent behavioral deficits following columnar-scale lesions. Thus, columnar-scale lesions permanently degrade performance in object location discrimination tasks.
A Role for Thalamic Projection GABAergic Neurons in Circadian Responses to Light
Authors: Brock Olivier , Gelegen Cigdem , Sully Peter , Salgarella Irene , Jager Polona , Menage Lucy , Mehta Ishita , Jęczmień-Łazur Jagoda , Djama Deyl , Strother Lauren , Coculla Angelica , Vernon Anthony C. , Brickley Stephen , Holland Philip , Cooke Samuel F. , Delogu Alessio 
Published: October 2022

The thalamus is an important hub for sensory information and participates in sensory perception, regulation of attention, arousal and sleep. These functions are executed primarily by glutamatergic thalamocortical neurons that extend axons to the cortex and initiate cortico-thalamocortical connectional loops. However, the thalamus also contains projection GABAergic neurons that do not extend axons toward the cortex. Here, we have harnessed recent insight into the development of the intergeniculate leaflet (IGL) and the ventral lateral geniculate nucleus (LGv) to specifically target and manipulate thalamic projection GABAergic neurons in female and male mice. Our results show that thalamic GABAergic neurons of the IGL and LGv receive retinal input from diverse classes of retinal ganglion cells (RGCs) but not from the M1 intrinsically photosensitive retinal ganglion cell (ipRGC) type. We describe the synergistic role of the photoreceptor melanopsin and the thalamic neurons of the IGL/LGv in circadian entrainment to dim light. We identify a requirement for the thalamic IGL/LGv neurons in the rapid changes in vigilance states associated with circadian light transitions.SIGNIFICANCE STATEMENTThe intergeniculate leaflet (IGL) and ventral lateral geniculate nucleus (LGv) are part of the extended circadian system and mediate some nonimage-forming visual functions. Here, we show that each of these structures has a thalamic (dorsal) as well as prethalamic (ventral) developmental origin. We map the retinal input to thalamus-derived cells in the IGL/LGv complex and discover that while RGC input is dominant, this is not likely to originate from M1ipRGCs. We implicate thalamic cells in the IGL/LGv in vigilance state transitions at circadian light changes and in overt behavioral entrainment to dim light, the latter exacerbated by concomitant loss of melanopsin expression.
A Common Neural Account for Social and Nonsocial Decisions
Authors: Arabadzhiyska Desislava H. , Garrod Oliver G.B. , Fouragnan Elsa , De Luca Emanuele , Schyns Philippe G. , Philiastides Marios G. 
Published: October 2022

To date, social and nonsocial decisions have been studied largely in isolation. Consequently, the extent to which social and nonsocial forms of decision uncertainty are integrated using shared neurocomputational resources remains elusive. Here, we address this question using simultaneous electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) in healthy human participants (young adults of both sexes) and a task in which decision evidence in social and nonsocial contexts varies along comparable scales. First, we identify time-resolved build-up of activity in the EEG, akin to a process of evidence accumulation (EA), across both contexts. We then use the endogenous trial-by-trial variability in the slopes of these accumulating signals to construct parametric fMRI predictors. We show that a region of the posterior-medial frontal cortex (pMFC) uniquely explains trial-wise variability in the process of evidence accumulation in both social and nonsocial contexts. We further demonstrate a task-dependent coupling between the pMFC and regions of the human valuation system in dorso-medial and ventro-medial prefrontal cortex across both contexts. Finally, we report domain-specific representations in regions known to encode the early decision evidence for each context. These results are suggestive of a domain-general decision-making architecture, whereupon domain-specific information is likely converted into a “common currency” in medial prefrontal cortex and accumulated for the decision in the pMFC.SIGNIFICANCE STATEMENTLittle work has directly compared social-versus-nonsocial decisions to investigate whether they share common neurocomputational origins. Here, using combined electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) and computational modeling, we offer a detailed spatiotemporal account of the neural underpinnings of social and nonsocial decisions. Specifically, we identify a comparable mechanism of temporal evidence integration driving both decisions and localize this integration process in posterior-medial frontal cortex (pMFC). We further demonstrate task-dependent coupling between the pMFC and regions of the human valuation system across both contexts. Finally, we report domain-specific representations in regions encoding the early, domain-specific, decision evidence. These results suggest a domain-general decision-making architecture, whereupon domain-specific information is converted into a common representation in the valuation system and integrated for the decision in the pMFC.
Seeing Social: A Neural Signature for Conscious Perception of Social Interactions
Authors: Varrier Rekha S. , Finn Emily S. 
Published: October 2022

Social information is some of the most ambiguous content we encounter in our daily lives, yet in experimental contexts, percepts of social interactions—that is, whether an interaction is present and if so, the nature of that interaction—are often dichotomized as correct or incorrect based on experimenter-assigned labels. Here, we investigated the behavioral and neural correlates of subjective (or conscious) social perception using data from the Human Connectome Project in which participants (n= 1049; 486 men, 562 women) viewed animations of geometric shapes during fMRI and indicated whether they perceived a social interaction or random motion. Critically, rather than experimenter-assigned labels, we used observers' own reports of “Social” or “Non-social” to classify percepts and characterize brain activity, including leveraging a particularly ambiguous animation perceived as “Social” by some but “Non-social” by others to control for visual input. Behaviorally, observers were biased toward perceiving information as social (vs non-social); and neurally, observer reports (compared with experimenter labels) explained more variance in activity across much of the brain. Using “Unsure” reports, we identified several regions that responded parametrically to perceived socialness. Neural responses to social versus non-social content diverged early in time and in the cortical hierarchy. Finally, individuals with higher internalizing trait scores showed both a higher response bias toward “Social” and an inverse relationship with activity in default mode and visual association areas while scanning for social information. Findings underscore the subjective nature of social perception and the importance of using observer reports to study percepts of social interactions.SIGNIFICANCE STATEMENTSimple animations involving two or more geometric shapes have been used as a gold standard to understand social cognition and impairments therein. Yet, experimenter-assigned labels of what is social versus non-social are frequently used as a ground truth, despite the fact that percepts of such ambiguous social stimuli are highly subjective. Here, we used behavioral and fMRI data from a large sample of neurotypical individuals to show that participants' responses reveal subtle behavioral biases, help us study neural responses to social content more precisely, and covary with internalizing trait scores. Our findings underscore the subjective nature of social perception and the importance of considering observer reports in studying behavioral and neural dynamics of social perception.
The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type‐III effector
Authors: Yu Gang , Derkacheva Maria , Rufian Jose S , Brillada Carla , Kowarschik Kathrin , Jiang Shushu , Derbyshire Paul , Ma Miaomiao , DeFalco Thomas A , Morcillo Rafael J L , Stransfeld Lena , Wei Yali , Zhou Jian‐Min , Menke Frank L H , Trujillo Marco , Zipfel Cyril , Macho Alberto P 
Published: October 2022

AbstractPlant immunity is tightly controlled by a complex and dynamic regulatory network, which ensures optimal activation upon detection of potential pathogens. Accordingly, each component of this network is a potential target for manipulation by pathogens. Here, we report that RipAC, a type III‐secreted effector from the bacterial pathogen Ralstonia solanacearum, targets the plant E3 ubiquitin ligase PUB4 to inhibit pattern‐triggered immunity (PTI). PUB4 plays a positive role in PTI by regulating the homeostasis of the central immune kinase BIK1. Before PAMP perception, PUB4 promotes the degradation of non‐activated BIK1, while after PAMP perception, PUB4 contributes to the accumulation of activated BIK1. RipAC leads to BIK1 degradation, which correlates with its PTI‐inhibitory activity. RipAC causes a reduction in pathogen‐associated molecular pattern (PAMP)‐induced PUB4 accumulation and phosphorylation. Our results shed light on the role played by PUB4 in immune regulation, and illustrate an indirect targeting of the immune signalling hub BIK1 by a bacterial effector.