bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Commissural Calcification on Clinical Outcomes of Percutaneous Mitral Valvuloplasty
Authors: Mazaherinia Homa , Hamidabad Negin Mahmoudi , Rostambeigi Saman , Kelsey Anita M. , Alizadehasl Azin , Sadeghpour Anita , Harandi Seyed Taha Hosseini , Farnoud Khashayar , Panahi Parsa 
Published: September 2022

Abstract
Background Percutaneous mitral valvuloplasty (PMV) is a safe and widely used treatment in patients with symptomatic rheumatic mitral stenosis. This study aimed to evaluate short-term and mid-term outcomes of PMV in patients with severe mitral stenosis and the effect of commissural calcifications on the outcomes.
Methods Medical records of 961 patients after PMV were reviewed. All patients were evaluated using transthoracic echocardiography before and after 24 hours. Patients were divided into three subgroups based on their Wilkins score (group I: score ≤8, group II: score 9-10, and group III: score 11-12). Also, patients were divided into two subgroups based on the presence or absence of commissural calcification. Patients were evaluated before PMV, 24 hours after the procedure and were followed for 6 and 24 months to evaluate the short-term and mid-term outcomes. The echocardiographic measures (mitral valve area, indexed mitral valve index, mitral valve mean gradient, and pulmonary artery systolic pressure) were compared after PMV, and at 6 months and 24 month follow-ups. Main clinical outcomes (moderate and severe mitral regurgitation and restenosis) were compared between patients with and without commissural calcifications.
Results:Mean age of the patients was 46.6 ± 12.2, and 81.7 % of patients (n=785) were females. Groups I, II, and III (based on Wilkins score) consisted of 353 (36.7%), 559 (58.1%), and 49 (5%) patients, respectively. Mitral valve area (MVA) and indexed MVA increased significantly in all three groups; in both short-term and mid-term follow-ups (p<0.0001). The rate of mitral valve restenosis was significantly higher in groups II and III compared to group I (P=0.0001), but the rate of significant mitral regurgitation (MR) (defined as >moderate MR) did not differ statistically between the three groups. Commissural calcification was present in 190 patients (19.77%). Restenosis was significantly higher in the presence of commissural calcification (p<0.0001). Also, the occurrence of significant MR was significantly higher in patients with commissural calcification (P=0.03).
Conclusion Both Wilkins score and presence of commissural calcification are associated with a higher incidence of mitral valve restenosis. While there is no strong association between higher Wilkins scores and higher rates of significant mitral regurgitation, commissural calcification is associated with a higher rate of severe mitral regurgitation.
Biosynthesis MgO and ZnO nanoparticles using chitosan extracted from Pimelia Payraudi Latreille for antibacterial applications
Authors: Amor Ilham Ben , Hemmami Hadia , Laouini Salah Eddine , Temam Hachemi Ben , Zaoui Hamza , Barhoum Ahmed 
Published: September 2022

Abstract
Chitosan (CS) is one of the most abundant biopolymers in nature, with superior properties including biocompatibility, biodegradability, lack of toxicity, antimicrobial activity, acceleration of wound healing, and stimulation of the immune system. In this study, chitosan was extracted from the exoskeletons of the beetle (Pimelia Payraudi Latreille) and then used for the biosynthesis of MgO NPs and ZnO NPs. The extracted chitosan exhibited excellent physicochemical properties, including high extraction yield (39%), high degree of deacetylation (90%), low ash content (1%), high fat-binding capacity (366%), and odd crystallinity index (51%). The MgO NPs and ZnO NPs exhibited spherical morphology with crystallite sizes of 17 nm and 29 nm, particle sizes of about 20-70 nm and 30-60 nm, and bandgap energy of 4.43 and 3.34 eV, respectively. Antibacterial assays showed that the extracted chitosan showed high antibacterial activity against Gram-(+/-) bacteria, while ZnO NPs showed much stronger antibacterial activity against Gram-(+) bacteria than against Gram(-) bacteria. For MgO NPs, the antibacterial activity against Gram-(+) bacteria was lower than that against Gram-(-) bacteria. The results suggest that the synthesized MgO NPs and ZnO NPs are excellent antibacterial agents for therapeutic applications.
Research progress on the mechanism of interleukin-1β on epiphyseal plate chondrocytes
Authors: Tong Ziyuan , Yang Xu , Li Jianjun 
Published: September 2022

Abstract

Epiphyses plate injury is one of the common problems in pediatric orthopedic surgeons. Interleukin-1β(IL-1β)-mediated inflammatory response is a major concern after clinical treatment of fractures and is bivalent in the growth and development of the epiphyses plate. As an extremely important inflammatory factor, IL-1β participates in the pathological development of a variety of bone and joint diseases by deeply affecting the molecular transcription level of chondrocytes and endocrine metabolism, and currently, there are few studies on epiphyses plate chondrocytes. Therefore, this review aims to illustrate the mechanism of IL-1β on chondrocytes and epiphyses plate chondrocytes, to shed light on theoretical grounds for clinical treatment and profound research of children epiphyses plate injury in the future.
The Exploration of Remote Simulation Strategies for the Acquisition of Psychomotor Skills in Surgery: a Pilot Randomized Controlled Trial
Authors: Guérard-Poirier Natasha , Meloche-Dumas Léamarie , Beniey Michèle , Torres Andrei , Kapralos Bill , Dhane Malek , Mercier Frédéric , Younan Rami , Dubrowski Adam , Patocskai Erica 
Published: September 2022

Abstract
Background
Progress in remote educational strategies was fueled by the advent of the COVID-19 pandemic. This pilot RCT explored the efficacy of a decentralized model of simulation based on principles of observational and peer-to-peer learning for the acquisition of surgical skills.
Methods
Sixty medical students from the University of Montreal learned the running subcuticular suture in four different conditions: 1) Control group 2) Self-learning 3) Peer-learning 4) Peer-learning with expert feedback. The control group learned with error-free videos, while the others, through videos illustrating strategic sub-optimal performances to be identified and discussed by students. Performance on a simulator at the end of the learning period, was assessed by an expert using a global rating scale (GRS) and checklist (CL).
Results
Students engaging in peer-to-peer learning strategies outperformed students who learned alone. The presence of an expert, and passive vs active observational learning strategies did not impact performance.
Conclusion
This study supports the efficacy of a remote learning strategy and demonstrates how collaborative discourse optimizes the students’ acquisition of surgical skills. These remote simulation strategies create the potential for implantation in future medical curriculum design.
Trial Registration: NCT04425499
Mesenchymal chondrosarcoma showing a sustained response to cabozantinib: A case report
Authors: Blum Veronika , Andrei Vanghelita , Ameline Baptiste , Hofer Silvia , Fuchs Bruno , Strobel Klaus , Allemann Anna , Bode Beata , Baumhoer Daniel 
Published: September 2022

Abstract
Background: Mesenchymal chondrosarcoma is a rare and aggressive sarcoma subtype with high risk for distant metastases and poor prognosis. Currently NCCN- and ESMO-Guidelines recommend using Ewing sarcoma protocols as standard treatment. Nevertheless, in localised disease overall 5-year survival rates are below 50% whereas in metastatic spread median progression-free survival rates of 5 months can be expected. Here we present a patient with metastatic osseous spread of mesenchymal chondrosarcoma that showed a sustained clinical improvement and a good partial response on imaging over a period of one year when treated with the multi-tyrosine kinase inhibitor cabozantinib as the sole systemic treatment.
Case presentation: Tissue samples from the primary tumour and three different metastases were subjected to methylation and copy number analysis, as well as DNA and RNA sequencing. The copy number profiles of both the primary and metastases revealed aneuploidy of chromosome 12, and a low-level copy number gain of MYC. Of note, all metastases showed homozygous loss at 9p21.3 harboring CDKN2a (p16) that was not present in the primary tumour. The Oncomine Comprehensive Panel v3 performed in one of the metastases did not reveal any point mutation within 135 cancer genes (including RB1­).
Conclusion and discussion: The sustained response to cabozantinib in the case presented here is most likely explained through inhibition of a complex interplay between VEGFR, PDGFR, PI3K-AKT- and Notch signalling pathways.
Numerical effect of seismic force on a medium arch dam
Authors: Khatib Milad , Loutfi Melissa , Hamdan Hani , Arairo Wahib 
Published: September 2022

Abstract
The dam is considered a huge structure that has multiple purposes in the life of a human. The most important role of a dam is the production of electricity, and the storage of a huge quantity of water. Therefore, it is very important to be vigilant in the studies made for it. Lebanon has indeed been designated as a seismicity country. However, the number of dams is increasing due to several natural consideration. Mseilha dam is an executed medium arch dam, which faced several problems during and after construction. The initial problem that faced a dam is the seismic force. This natural force is very dangerous for any structure, especially for a dam. It could increase the existing concrete stresses. These stresses will cause the development of cracks all along the dam. Once the concrete shows cracks, its resistance will decrease, and it will become more vulnerable to external effects. Several studies were made to fortify it and make it resistant to seismic force. To show the major effect of this force, two methods ‘pseudo-static’ and ‘response spectrum’ were applied to a medium arch dam. Therefore, to evaluate the performance of these two methods, the dam is modelled using finite element software. The obtained results show the importance of using the appropriate model in the design of such dams without taking the appropriate model.
Stable isotope composition in precipitation and groundwater of Shwan Sub-Basin, Kirkuk governorate, northeast of Iraq
Authors: Al-Gburi Hind Fadhil , Al-Tawash Balsam Salim , Al–Tamimi Omer Sabah , Schüth Christoph 
Published: September 2022

Abstract
Stable isotope composition of δ2H and δ18O was investigated in the water resources of the Shwan sub-Basin northeast of Iraq. The study objects conceived the possible factors that affect the stable isotopes’ composition in precipitation additionally to achieve information concerning recharge processes and estimate the groundwater recharge sources. In this study, four precipitation samples were collected at the study area for the 2020–2021 hydrological year. Thirty-two groundwater samples and one surface water sample from Lesser Zab River (LZR) were collected during the same period for two sampling seasons. The results of observed meteorological data show a very small amount of precipitation for the sampling year. This year is considered a dry hydrological year with total annual precipitation of 100.62 mm compared with the previous 40 hydrological years with total annual precipitation of 325.43 mm. The isotopic composition in precipitation was highly varied as it primarily depends on environmental conditions. The depleted values are recognized with the increasing precipitation amount, whereas the enriched values were the most affected by evaporation. Back trajectory analysis revealed that stable isotopes in precipitation are primarily influenced by air masses and moisture sources. The sources of the trajectory that came from the Mediterranean Sea, Arabian Gulf and the Red Sea would lead to variations in the values of precipitation stable isotope. Stable isotope values in groundwater showed that the samples for both periods are located between the East Mediterranean water line (EMWL) and global meteoric water line (GMWL) close to the local meteoric water line (LMWL) indicating that the groundwater recharge is mainly through precipitation. Groundwater recharges by an indirect recharge mechanism from the LZR, based on stable isotope similarity between depleted stable isotopes in groundwater and river water. The estimated groundwater recharge based on weighted oxygen isotopes is about 9.2% of annual rainfall infers that the recharge during the sampling year was very low. The low recharge value experiences dry weather conditions from low precipitation amounts besides increasing evaporation during the current study.
An Algorithm Recommendation for Management of Allergic Rhinitis in the
United Arab Emirates: A Consensus Statement from an Expert Panel
Authors: Mahboub Bassam , El-Hefny Yousef , Al-Fraihat Ayman , Persaud Ricardo , Juratli Abdul , Tadros Faheem , Aljassim Abdul , Hantzakos Anastasios , Hoffmann Bernard , Alabdali Khairullah , Elmesallamy Khalid , Shkoukani Mahdi , Mohamed Taher , Alrakhawy Mohamed 
Published: September 2022

Background:
Allergic rhinitis (AR) is a common chronic health problem in the United Arab Emirates (UAE). Achieving adequate symptom control is pivotal to successful AR management, which may be attained following a stepwise treatment algorithm. Despite the availability of several guideline recommendations for the best management of AR, morbidity remains high in patients with AR, with treatment goals being far from the reach.

Objective:
The objective of this consensus statement was to discuss the currently available knowledge on the treatment of AR and to provide an expert opinion on the use of MP-AzeFlu (azelastine HCl, AZE; 137 µg per spray) and INCS (fluticasone propionate, FP; 50 µg per spray) for the effective management of AR in the UAE.

Methods:
A consensus meet involving 13 otorhinolaryngologists and one pulmonologist was held in Dubai, UAE, to discuss the current understanding on the treatment and management of AR.

Results:
The panel advised to start AR pharmacotherapy with antihistamines (AH), leukotriene receptor antagonist (LTRA), INCS or MP-AzeFlu based on the visual analogue scale (VAS) score. In mild intermittent AR (VAS score <5/10), AH or LTRA is recommended as first-line therapy. However, in case of VAS score ≥5/10 or persistent AR, and treatment failure with AHs alone, INCS or MP-AzeFlu is recommended followed by reassessment for 7 days to confirm a step-up or step-down down therapy. Patients non-responsive to therapy were advised to step-up with MP-AzeFlu.

Conclusion:
The panel advocated a combination of intranasal second-generation AH and INCS in a single device (Dymista®) as first-line therapy for the management of AR. The algorithm provided herein can be applied in most healthcare settings by following a step-up or step-down strategy based on the VAS scores for AR control in the UAE.
Assessing the Racial and Socioeconomic Disparities in Postpartum Depression Using Population-Level Hospital Discharge Data: Longitudinal Retrospective Study
Authors: Liu Star , Ding Xiyu , Belouali Anas , Bai Haibin , Raja Kanimozhi , Kharrazi Hadi 
Published: September 2022

Background
In the United States, >3.6 million deliveries occur annually. Among them, up to 20% (approximately 700,000) of women experience postpartum depression (PPD) according to the Centers for Disease Control and Prevention. Absence of accurate reporting and diagnosis has made phenotyping of patients with PPD difficult. Existing literature has shown that factors such as race, socioeconomic status, and history of substance abuse are associated with the differential risks of PPD. However, limited research has considered differential temporal associations with the outcome.

Objective
This study aimed to estimate the disparities in the risk of PPD and time to diagnosis for patients of different racial and socioeconomic backgrounds.

Methods
This is a longitudinal retrospective study using the statewide hospital discharge data from Maryland. We identified 160,066 individuals who had a hospital delivery from 2017 to 2019. We applied logistic regression and Cox regression to study the risk of PPD across racial and socioeconomic strata. Multinomial regression was used to estimate the risk of PPD at different postpartum stages.

Results
The cumulative incidence of PPD diagnosis was highest for White patients (8779/65,028, 13.5%) and lowest for Asian and Pacific Islander patients (248/10,760, 2.3%). Compared with White patients, PPD diagnosis was less likely to occur for Black patients (odds ratio [OR] 0.31, 95% CI 0.30-0.33), Asian or Pacific Islander patients (OR 0.17, 95% CI 0.15-0.19), and Hispanic patients (OR 0.21, 95% CI 0.19-0.22). Similar findings were observed from the Cox regression analysis. Multinomial regression showed that compared with White patients, Black patients (relative risk 2.12, 95% CI 1.73-2.60) and Asian and Pacific Islander patients (relative risk 2.48, 95% CI 1.46-4.21) were more likely to be diagnosed with PPD after 8 weeks of delivery.

Conclusions
Compared with White patients, PPD diagnosis is less likely to occur in individuals of other races. We found disparate timing in PPD diagnosis across different racial groups and socioeconomic backgrounds. Our findings serve to enhance intervention strategies and policies for phenotyping patients at the highest risk of PPD and to highlight needs in data quality to support future work on racial disparities in PPD.
18 O enrichment of sucrose and photosynthetic and non-photosynthetic leaf water in a C 3 grass -- atmospheric drivers and physiological relations
Authors: Cabrera Juan C. Baca , Hirl Regina T. , Zhu Jianjun , Schäufele Rudi , Ogée Jérôme , Schnyder Hans 
Published: September 2022

The O enrichment (Δ O) of leaf
water affects the Δ O of photosynthetic products
such as sucrose, generating an isotopic archive of plant function and
past climate. However, uncertainty remains regarding how leaf water
compartmentation between photosynthetic and non-photosynthetic tissue
affects the relationship between Δ O of bulk leaf
water (Δ O ) and leaf sucrose (Δ
O ). We grew Lolium
perenne (a C grass) in mesocosm-scale, replicated
experiments with daytime relative humidity (RH 50 or 75%) and CO
level (200, 400 or 800 μmol mol )
as factors, and determined Δ O , Δ
O and morpho-physiological
leaf parameters, including transpiration ( E), stomatal conductance ( g) and mesophyll conductance to CO (
g). The Δ O of
photosynthetic medium water (Δ O
) was estimated from Δ O
and the equilibrium fractionation between water
and carbonyl groups (ε ). Δ O
was well predicted by theoretical estimates of leaf
water at the evaporative site (Δ O
) with adjustments that correlated with gas exchange
parameters ( g or total conductance to CO
). Isotopic mass balance and published work indicated
that non-photosynthetic tissue water was a large fraction
(~0.62) of bulk leaf water. Δ O
was a poor proxy for Δ O
, mainly due to opposite Δ O
responses of non-photosynthetic tissue water (Δ O
) relative to Δ O
, driven by atmospheric conditions.
EFEKTIVITAS TEPUNG PISANG BERLIN (Musa acuminata) MENTAH TERHADAP KADAR HDL (High Density Lipoprotein) TIKUS DISLIPIDEMIA
Authors: Subekti Qorina Alif Firdausy , Damayati Ratih Putri , Agustin Firda , Febriyatna Ayu 
Published: September 2022

Dislipidemia merupakan kelainan metabolisme lipid yang ditandai dengan peningkatan ataupun penurunan kadar fraksi lipid di dalam plasma. Salah satu tanda yang terjadi pada penderita dislipidemia yaitu penurunan kadar HDL(High Density Lipoprotein). HDL biasa dikenal sebagai kolesterol baik yang mana akan membawa kolesterol dari sel dan jaringan ke dalam hati. Pati resisten dan flavonoid berperan dalam meningkatkan kadar HDL. Tepung pisang berlin mentah yang mengandung pati resisten dan flavonoid. Tujuan penelitian ini adalah untuk mengetahui pengaruh berbagai dosis dalam meningkatkan kadar HDL tikus wistar dislipidemia. Jenis penelitian ini adalah true-experimental dengan pre test - post test with control group design. Penelitian ini menggunakan 30 ekor tikus wistar jantan usia 2-3 bulan dengan berat badan 150-200 gram. Tikus dibagi menjadi lima kelompok (K-, K+, P1 0,144g/ekor/hari, P2 0,288g/ekor/hari, dan P3 0,576g/ekor/hari). Kadar HDL diperiksa dengan metode Presipitasi. Data dianalisis menggunakan uji One Way Anova untuk uji beda antar kelompok dan Paired T-Test untuk uji beda sebelum dan setelah perlakuan masing-masing kelompok. Hasil penelitian menunjukkan tidak ada nilai signifikan antara semua kelompok sebelum diberikannya perlakuan, tidak ada perbedaan yang signifikan antara kelompok sesudah perlakuan (p=0,512). Terdapat nilai signifikan pada kelompok (K-), (K+), (P1), (P3) tetapi tidak terdapat perbedaan yang signifikan pada sebelum dan setelah pemberian pada kelompok P2, tidak terdapat perbedaan yang signifikan selisih sebelum dan sesudah pemberian tepung pisang berlin. Kesimpulan dari penelitian ini bahwa pemberian tepung pisang berlin mentah tidak berpengaruh terhadap peningkatan HDL pada tikus dislipidemia. Kata Kunci: Dislipidemia, HDL, pati resisten, tepung pisang berlin mentah.
Lonely in the socio-cultural dimension: variation in research
Authors: Korkiya E. D. 
Published: September 2022

The author in this article raises the topical issue of loneliness. The focus on this phenomenon is linked to the instability and uncertainty of the current sociocultural situation in a rapidly globalizing world. The changes that are taking place in the political, social, cultural and economic spheres of a State, as well as in the world as a whole, have an impact on the structure of interpersonal communication and identity.The author points out that in the 20th century the phenomenon of loneliness is seen through the lens of "extreme situation", in both atheistic and religious existentialism. And in religious existentialism, the loneliness of man in the "extreme situation" is a prerequisite for understanding God as a transcensency, whereas in atheistic terms, the attempt to realize leads to the conclusion of the absurdity of human existence and entails the isolation of man, feeling alone. The article shows that today’s realities make it imperative for the individual to mobilize all resources in order to develop adaptive capacities corresponding to a constantly evolving world. But not everyone is capable of accepting previously unfamiliar living conditions. There are many who feel the pain of losing the ties that were important to them, who feel the agony of not being able to acquire new ones, even though they are urgently needed. The text defines a single person as a subject of communication who experiences difficulties in social interaction. The author also shows that loneliness affects an individual in the following way: it can both distort a person’s perception of social action and have a positive effect on the individual, contributing to serious spiritual development.The author concludes that loneliness, being a key point of dissatisfaction with oneself and oneself (the position in society), can be an impulse for the need to analyse internal experiences, to understand life’s problems and eventually to understand its place in the world.