bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brinzolamide- and latanoprost-loaded nano lipid carrier prevents synergistic retinal damage in glaucoma
Authors: Chen Liping , Wu Ruixin 
Published: May 2022

Glaucoma is a common eye disease and a major cause of blindness. We designed brinzolamide (Brla)- and latanoprost (Ltp)-loaded nano-lipoidal carriers (NLCs) for glaucoma treatment. Brla and Ltp-loaded NLCs were designed and characterized by assessing the zeta potential, polydispersity index, X-ray diffraction and scanning electron microscopy images, and particle size. Drug release was assessed by in vitro and ex vivo methods to determine transcorneal permeation, ocular irritation, and cell viability. Moreover, Brla- and Ltp-loaded NLCs were assessed in terms of the management of raised intraocular pressure (IOP). The size of Brla- and Ltp-loaded NLCs was <200 nm, the drug entrapment efficiency was 97.5%, and the zeta potential was 35.33 mv. The transcorneal permeation levels of Blra and Ltp after 8 h were 50.5% and 49.4%, respectively; after 24 h, they were 81.4% and 84.2%, respectively. However, NLCs are not cytotoxic. Moreover, Brla+Ltp-treated NLCs effectively reduced IOP in glaucoma patients. Therefore, Brla+Ltp-loaded NLCs showed promising effects against glaucoma.
Integrated design approaches with photovoltaic panel and solar collectors in building envelope
Authors: Kaya Gevher Nesibe , Beyhan Figen 
Published: May 2022

Resources are running out and the use of fossil resources, which threaten the future of life due to the negative environmental effects, and the limitations and cost increases caused by dependence on energy production have made energy efficiency the main priority of the world countries. In this context, efforts to obtain energy from alternative energy sources have gained momentum within the framework of the targets of safe energy supply and energy independence, as well as energy conservation. The use of solar energy has come to the fore among these studies with its accessibility, affordable cost and environmental effects. With the increasing tendency towards net zero energy buildings in the design of buildings, which have a large share in terms of energy consumption, approaches of "the buildings can meet the energy they need with the help of solar energy" have been developed. In this context, the aim of the study is to examine the integrated design principles and application methods of photovoltaic panels (PV) and solar collectors, which have found much more place in building envelope designs in recent years. First of all, PVs and solar collectors, defined as active solar systems, were examined in terms of system components, applicability and efficiency, then the design approaches of building integrated photovoltaic panels (BIPV) and building integrated solar collectors (BIST) were investigated detailed. Their advantages and disadvantages have been identified for the applications of these systems in buildings. Finally, the integrated design approach has been evaluated over the sample buildings. In the results, the potentials and importance of BIPV-BIST technologies in the context of energy efficiency were discussed, taking into account the integrated design approaches.

Keywords: Renewable, integrated design, BIPV, BIST, energy efficiency
A new approach using artificial neural network and support vector machine models to predict the permeate flux of a rotating disk membrane
Authors: Ladeg Soufyane , Laidi Maamar , Moussaoui Mohamed , Moulai-Mostefa Nadji 
Published: May 2022

Abstract
The modeling of the permeate flux of a rotating disk membrane (RDM) filtration was investigated in this paper. Two computational intelligence techniques namely artificial neural networks (ANN) and support vector machine (SVM) were employed to model the permeate flux based on seven input variables including time of filtration, concentration of the feed fluid, transmembrane pressure, rotating velocity, dynamic velocity of the feed fluid, pore diameter of the membrane and, density of the feed fluid. The best-fit model was selected through the trial-error method and the two statistical parameters including the coefficient of determination (R²) and the average absolute relative deviation (AARD) between experimental and predicted data. The results obtained showed that the optimized ANN model can predict the permeate flux with R² = 0.999 and AARD% = 2.245 versus the SVM model with R² = 0.996 and AARD% = 4.09. Furthermore, the ANN model showed a high ability to predict the permeate flux in comparison with the SVM approach. The applicability domain of the ANN model was conducted to identify the outliers of the database and, the sensibility analysis of inputs on the output was employed for the determination of the relevant input variables.
The effect of vitamin D on sexual function: A systematic review
Authors: Banaei Mojdeh , Ghasemi Vida , Roozbeh Nasibeh , Mohammadsouri Behzad , Darsareh Fatemeh , Mehrnoush Vahid , Shahri Leila Mohamad-Khani , Darooneh Tayebeh 
Published: May 2022

Abstract
Background and Aim: Sexual function is one of the important aspects of human health and quality of life that is affected by various factors. Recently, some evidence reported the relationship between hypovitaminosis and sexual dysfunction, and some studies show the effect of vitamin D supplementation on sexual function. The aim of this study was to evaluate the effect of vitamin D on sexual function in both men and women. Methods: This systematic review study assessed all clinical trial articles found in search databases (Cochrane, PubMed / Medline, Embase via Ovid, ProQuest, Scopus, and WOS) without language restriction, until 24/01/2022. Article extraction was performed using the Endnote X8.2 software and duplicate titles were excluded. After screening the titles and abstracts, the two researchers independently conducted quality assessments of studies using the Cochran's risk of bias tool and RevMan 5.4 software. Then, the data were extracted by three authors independently using a researcher-made form. Results: This systematic review, included 8 final articles with a total sample size of 464 (including 217 women and 247 men). Four studies evaluated the effect of vitamin D on male sexual function and 4 studies evaluated the effect of vitamin D on female sexual function. Vitamin D supplementation has been shown in studies to improve both men’s and women’s sexual function. Conclusion: In general, the current study's findings show that vitamin D supplementation had a significant positive effect on both men and women's sexual function. More research in larger and more diverse populations, however, is required to establish the definitive causal relationship and the importance of measuring and prescribing vitamin D in the protocol for the diagnosis and treatment of sexual disorders.
Pelvic floor muscle strength, urinary incontinence and quality of life in women with Multiple Sclerosis
Authors: Afshari Poorandokht , Abedi Parvin , Majdinasab Nastaran , Tafakh Samaneh , Haghighizadeh Mohammadhossein 
Published: May 2022

Abstract
Background: Multiple sclerosis (MS) is a disabling autoimmune disease that mostly affects females. This study aimed to evaluate the relationship of pelvic muscle strength with urinary problems and quality of life. Methods: In this cross-sectional study, 87 women with MS were recruited. A demographic questionnaire, the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF), and Quality of Life Questionnaire (QOL-SF-36) were used to collect the data. The strengths of perineal muscle were measured using a perineometer. Data analyzed using Pearson correlation test, and multiple linear regression tests. Results: Pelvic muscle strength had a positive correlation with all domains of quality of life except for pain and role limitations due to emotional problems. Urinary incontinence had a reverse significant correlation with all domains of quality of life except for pain. A one-unit increase in the quality of physical life brought about a .15-unit increase in the strength of pelvic floor muscles (P =.035). A one-year increase in length of marriage or length of disease caused the strength of the pelvic floor muscles to decrease by.24 units and .509 units, respectively (P < .05). Conclusion: There is a relationship between pelvic muscle strength, urinary incontinence, and quality of life in female patients with multiple sclerosis. Length of marriage and length of MS disease were inversely related to the strength of the pelvic floor muscles. Health providers are recommended to educate MS patients about the importance of pelvic muscle strength.
A stress-induced cilium-to-PML-NB route drives senescence initiation
Authors: Hu Jinghua , Ma Xiaoyu , Zhang Yingyi , Zhang Yuanyuan , Zhang Xu , Huang Yan , He Kai , Chen Chuan , Hao Jielu , Zhao Debiao , LeBrasseur Nathan , Kirkland James , Chini Eduardo , Wei Qing , Ling Kun 
Published: May 2022

Abstract
Cellular senescence contributes to tissue homeostasis and age-related pathologies. However, how senescence is initiated in damaged cells remains vague. Here, we discover that irreparable stresses induce transient biogenesis of cilia, which are used by stressed cells to directly communicate with the promyelocytic leukemia nuclear bodies (PML-NBs), the validated stress signaling hub, to initiate senescence responses. Mechanistically, a ciliary ARL13B-ARL3 GTPase cascade negatively regulates the association of transition fiber protein FBF1 and SUMO-conjugating enzyme UBC9. Irreparable stresses downregulate the ciliary ARLs to release UBC9, which SUMOylates FBF1 at the ciliary base. SUMOylated FBF1 then translocates to PML-NBs to promote PML-NB-dependent senescence initiation. Remarkably, Fbf1 suppression effectively subdues global senescence burden and prevents associated health-span decline in irradiation-treated mice. Collectively, our findings assign primary cilia a central role in inducing senescence program and identify them as promising targets to dampen senescence-associated detrimental damage in future senotherapy strategies.
Analysis of seismic damage of a highway bridge during the 2021 Ms 7.4 earthquake in Maduo County, China
Authors: Ding Wanpeng , Wu Zhijian , Zhan Beilei , Liu Jian 
Published: May 2022

Abstract
On May 22, 2021, a 7.4 magnitude earthquake struck Maduo County (34.59°N, 98.34°E), Qinghai Province, China, with a focal depth of 17 km. The earthquake occurred near the northern boundary of the Bayan Har block. Two highway bridges, including the Yematan bridge, collapsed. Based on the analysis of the seismic damage characteristics of the Yematan bridge, a finite element model of a three-span simply supported girder bridge was established. Nonlinear analyses were performed using the bedrock wave at the bridge site during the earthquake and the seismic safety evaluation wave of the bridge as inputs to analyze the causes of seismic damage to the bridge. The results show that the large beam displacement owing to the velocity pulse and the low-frequency components of the ground motion are the main causes of the damage to the bridge.
Two-dimensional modeling of flooding in Fragoso River floodplain with tidal influence in Olinda city (Brazil)
Authors: Rodrigues Arivânia Bandeira , CABRAL JAIME 
Published: May 2022

Abstract
Population growth and consequent changes in land use associated with climate change have proved that traditional drainage methods are inefficient. As a result, the need for new techniques has emerged, such as flood simulations for risk and danger assessment using two-dimensional resolutions of flood wave propagation for flooding problems in urban areas. Thus, the present work sought to evaluate structural measures and their effects on floods in a case study in Olinda city in response to different rainfall events in Fragoso River Basin, Pernambuco State (Brazil). This region has a disordered urbanization process associated with a vulnerable drainage system. Several scenarios were evaluated to obtain the floodable areas and hazard indicator maps, with simulations before and after the construction of the Fragoso channel. PCSWMM and HEC-RAS software were used to perform hydrological and two-dimensional hydrodynamic modeling. For land use characterization, MapBiomas data were applied. Lidar technology project with laser terrain survey (the so-called Pernambuco Tridimensional - PE3D) was used for geomorphology data. Simulation results were satisfactory for a better understanding of the flooding area. Comparing simulations before and after Fragoso channel completion, a reduction in the total flooded area was obtained, but the flooding problems will persist. Results of this study can contribute to informing risk assessments and support decision-making regarding flooding in estuarine plains.
Hydrochemical indices as a proxy for assessing land-use impacts on water resources: A sustainable management perspective and case study of Can Tho City, Vietnam
Authors: Duc Nguyen Hong , Kumar Pankaj , Lan Pham Phuong , Kurniawan Tonni Agustiono , Khedher Khaled Mohamed , Kharrazi Ali , Saito Osamu , Avtar Ram 
Published: May 2022

Abstract
Can Tho City is experiencing water stress driven by rapid global changes. This study assesses the spatiotemporal variation in surface water quality (SWQ) through a multivariate statistical approach to provide evidence-based scientific information supporting sustainable water resource management and to contribute to achieving the city’s sustainable development goals (SDGs). The complex SWQ dataset with 14 monthly-measured parameters at 73 sampling sites throughout the city were collected and analyzed. The obtained results indicated that average concentrations of biochemical oxygen demand (BOD), chemical oxygen demand (COD), dissolved oxygen (DO), total coliform (TC), turbidity, total suspended solids (TSS), and phosphate (PO43−) exceeded the permissible national levels. Spatially, cluster analysis (CA) was divided the city’s river basin into three different zones (mixed urban-industrial, agricultural, and mixed urban-rural zones). The key sources of SWQ pollution in these three zones were individually identified by principal component/factor analysis (PCA/FA), which were mainly related to domestic wastewater, industrial effluents, farming runoff, soil erosion, upstream sediment flows, and severe droughts. Discriminant analysis (DA) also explored that COD, DO, turbidity, nitrate (NO3−), and PO43− were the key parameters discriminating SWQ in the city among seasons and land-use zones. The temporally-analyzed results from Weighted Arithmetic Water Quality Index (WAWQI) estimation revealed the deterioration of SWQ conditions, whereby, the total polluted monitoring sites of the city, increased from 29% in 2013 to 51% in 2019. The key drivers accused of this deterioration were the expansion in built-up and industrial land areas, farming runoff, and droughts.
Utilization of carbide slag in autoclaved aerated concrete preparation
Authors: Luo Kai , Peng Ke , Li Jun , Lu Zhongyuan , Jiang Jun 
Published: May 2022

Abstract
Lime is one of the main raw materials necessary for the production of autoclaved aerated concrete (AAC). The preparation of lime through calcining limestone directly/indirectly emits large amount of CO2 due to the limestone decomposition and energy consumption. In this study, AAC was proposed by using modified carbide slag (MCS) instead of lime, which can effectively utilize solid wastes and reduce the CO2 emission. Results showed in the first two hours of hydration, the heat release rate of MCS was higher than that of lime, and the cumulative hydration heat of lime and MCS within 30 h is 206.1 J/g and 204.3 J/g, respectively. MCS can not only improve the fluidity of slurry, but also enhance the gas-foaming rate. Cumulative pore volume increased with the increase of MCS content in AAC. Tobermorite, quartz, katoite, anhydrite and calcite are the main minerals in AAC. With the increase of MCS content, the density and strength of AAC decrease and the thermal insulation performance increase. When the MCS content is 100%, the AAC density is 594 kg/m3, the compressive strength is 3.6 MPa and the thermal conductivity is 0.141 W·m− 1·K− 1, meets B06 A3.5 in Chinese standard GB 11968 − 2019.
Differentially Private Knowledge Transfer for Federated Learning
Authors: Qi Tao , Wu Fangzhao , Wu Chuhan , Huang Yongfeng , Xie Xing 
Published: May 2022

Abstract
Extracting useful knowledge from big data is important for machine learning. When data is privacy-sensitive and cannot be directly collected, federated learning is a promising option that extracts knowledge from decentralized data by learning and exchanging model parameters, rather than raw data. However, model parameters may encode not only non-private knowledge but also private information of local data, thereby transferring knowledge via model parameters is not privacy-secure. Here, we present a novel knowledge transfer method named PrivateKT, which uses actively selected small public data to transfer high-quality knowledge in federated learning with privacy guarantees. We verify PrivateKT on three different datasets, and results show that PrivateKT can maximally reduce 84% of the performance gap between centralized learning and existing federated learning methods under strict differential privacy restrictions. PrivateKT provides a potential direction to effective and privacy-preserving knowledge transfer in machine intelligent systems.
Cost-effectiveness analysis of Ultra-hypofractionated radiotherapy and conventionally fractionated radiotherapy for intermediate-to-high-risk localized prostate cancer
Authors: He Jiaoxue , Wang Qingfeng , Hu Qiancheng , Li Changlin 
Published: May 2022

Abstract
Background: Radiotherapy is an effective curative treatment option for intermediate-to-high-risk localized prostate cancer. Given that no significant difference was observed in survival and toxicities, we evaluated the cost-effectiveness of ultra-hypofractionated radiotherapy and conventionally fractionated radiotherapy for intermediate-to-high-risk localized prostate cancer from the Chinese payer perspective.Methods: We developed a Markov model with a 15-year time horizon to compare the cost and effectiveness of ultra-hypofractionated radiotherapy with those of conventionally fractionated radiotherapy for localized intermediate-to-high-risk prostate cancer. Outcomes were measured in quality-adjusted life-years (QALYs), incremental cost-effectiveness ratio (ICER), and willingness-to-pay (WTP). Univariable and probability sensitivity analyses were performed to evaluate the robustness of the Markov model.Results: Based on the results of our Markov model, the conventionally fractionated radiotherapy yielded 2.32 QALYs compared with 2.14 QALYs in the ultra-hypofractionated radiotherapy in China. The cost of ultra-hypofractionated radiotherapy was found to be decreased by about 14% folds ($4251.04) in comparison to that of conventionally fractionated radiotherapy. The ICER of conventionally fractionated radiotherapy vs the ultra-hypofractionated radiotherapy was $23,616.89 per QALY in China. The most sensitive parameters were the ultra-hypofractionated radiotherapy utility of failure-free survival (FFS) with grade two or worse urinary toxicity and discount rate per annum. The cost effectiveness acceptability curve showed that conventionally fractionated radiotherapy had a 57.7% probability of being cost-effective at the Chinese WTP threshold.Conclusion: The ultra-hypofractionated radiotherapy was not a cost-effective strategy compared with conventionally fractionated radiotherapy in patients with localized intermediate-to-high-risk prostate cancer from the perspective of the Chinese payers. However, steep reductions in the grade two or worse urinary toxicity of the ultra-hypofractionated radiotherapy could alter the results.
Soil quality decay rate and plant traits in green manure following monocropping farming systems at tropical conditions
Authors: Nascimento Gislaine dos Santos , Souza Tancredo , Silva Lucas Jónatan Rodrigues da , Laurindo Lídia Klestadt , Barros Izabelle Cristine , Santos Djail , Freitas Helena , de Sousa José Paulo 
Published: May 2022

Abstract
Aims
Soil quality index shed light on soil health and its capacity to sustain high primary production. It also can assist decision-making in farming systems by integrating this valuable product into soil management planning. However, the currently existing models are based on rather local data, and thus, there is a lack of predictive tools to monitor soil quality.
Methods
We characterized soil chemical properties, and plant biomass production during 6 years in field conditions at a tropical soil.
Results
Our findings suggest that: 1) a consecutive green manure practice without any input of fertilizers after 6 years reduced soil quality in tropical savanna climate conditions; and 2) there are three groups of green manure considering soil quality reduction, G1 (low soil quality reduction) that comprises C. ochroleuca and N. wightii, G2 (medium soil quality reduction) that comprises B. decumbens, P. glaucum, and C. juncea, and G3 (high soil quality reduction) that comprises M. pruriens, C. ensiformis, C. spectabilis, D. lablab, and S. aterrimum.
Conclusions
This study highlights the importance to consider predictive models as a tool to be used in soil management. Our study also provides a deeper view about the use of green manure, and the importance to avoid the use of green manure with traits that decrease soil quality.
Empirical Evidence from OECD and BRICS Countries on the Impact of Investor Behavior on Renewable Energy Deployment
Authors: Ata Nurcan Kilinc , Dolmatov Ilya A. 
Published: May 2022

Abstract
The importance of employing Renewable Energy (RE) sources has recently expanded significantly, particularly in light of growing worries about climate change issues and rising fossil-fuel prices constituting a substantial threat to the country's economies. However, there has been very little examination of RE deployment from the perspective of investors to date. For this reason, determining the most successful investor behavior in the deployment of RE is critical. In terms of the establishment of a conceptual framework, the current paper provides a systematic and quantitative measure to compare the implications of variables in OECD and BRICS countries. This study employs a variety of panel regression procedures such as panel unit test, fixed and random effects model, generalized method of moments (GMM), and robustness check to investigate the determinants of RE investment in OECD and BRICS nations through a panel data study from 2000 to 2020. Economic growth, RE policy, and R&D spending all have a statistically significant and positive association with RE capacity, according to the GMM data. RE investment, on the other hand, is inversely related to energy, electricity use, and carbon emissions (CO2). Strong regulatory (policy, R&D) perception is significant in RE investment.