bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salidroside rescues barium chloride-induced skeletal muscle injury
Authors: Shen Yuntian , Li Ming , Xie Huimin , Wang Lingbin , Liu Hua , Wang Wei , Ji Yanan , Yu Miaomei , Shen Hongmei , Zhou Songlin 
Published: September 2022

Abstract
Skeletal muscle, as an important part of the human body, participates in a variety of body functions. The imbalance of homeostasis in skeletal muscle may be closely related to skeletal muscle growth or atrophy of skeletal muscle and the decrease of muscle function. Salidroside (Sal) is a bioactive component extracted from Rhodiola rosea. It has various pharmacological properties, including antioxidant, anti-aging and anti-fatigue properties. However, there are few studies about the effect of Sal on skeletal muscle injury induced by Barium chloride (BaCl2), which damages muscle fibers by depolarizing sarcolemmal and cause Ca2+ overload and membrane rupture. Sal significantly inhibited and reversed the decrease in cross-sectional area and diameter of muscle fibers induced by BaCl2 with HE staining, and increased the expression of myogenic differentiation 1 (MyOD1). Additionally, Sal administration enhances the regeneration potential of satellite cells and accelerates the regenerative process. In other words, Sal shows some degree of protective effects on chemical skeletal muscle injuries.
Furosemide exacerbated the impairment of renal function, oxygenation and medullary damage in a rat model of renal ischemia/reperfusion induced AKI.
Authors: Dilken Olcay , Ince Can , Kapucu Aysegul , Heeman Paul M. , Ergin Bülent 
Published: September 2022

Abstract
Background: Perioperative Acute Kidney Injury (AKI) caused by Ischemia-Reperfusion (IR) is a significant contributor to mortality and morbidity after major surgery. Furosemide is commonly used in postoperative patients to promote diuresis and reduce tissue edema. However, its effects on renal microcirculation, oxygenation and function after AKI are poorly understood. Herein, we investigated the effects of furosemide in rats subjected to IR insult.
Methods: 24 Wistar albino rats were divided into 4 groups, with 6 in each; Sham-operated Control (C), Control + Furosemide (C+F), ischemia/reperfusion (IR), and IR+F. After induction of anaesthesia (BL), supra-aortic occlusion was applied to IR and IR+F groups for 45 minutes followed by ongoing reperfusion for 15 minutes (T1) and 2 hours(T2). Furosemide infusion was initiated simultaneously in the intervention groups after ischemia. Renal blood flow (RBF), vascular resistance (RVR), oxygen delivery (DO2ren) and consumption (VO2ren), sodium reabsorption (TNa+), oxygen utilization efficiency (VO2/TNa+), cortical (CμO2) and medullar (MμO2) microvascular oxygen pressures, urine output (UO) and creatinine clearance (Ccr) were measured. Biomarkers of inflammation, oxidative and nitrosative stress were measured and kidneys were harvested for histological analysis.
Results: IR significantly decreased RBF, mainly by increasing RVR, which was exacerbated in the IR+F group at T2 (2198 vs 4223 dyne/s/cm5, p<0.05). CμO2 (61.65±6.8 vs 86.02±6.67 mmHg) and MμO2 (51.18±4.16 vs 68.79±4.98 mmHg, p<0.05) were both reduced after IR and did not improve by Furosemide. Moreover, VO2/TNa+ deteriorated in the IR+F compared to IR (78,5±63% vs IR+F:422,5±707% compared to BL values, p=0,07) suggesting a possible harm. Ccr did not change and plasma creatinine increased significantly in IR+F. Histopathology revealed widespread damage both in the cortex and medulla in IR+F and C+F groups.
Conclusion: Renal oxygen delivery, medullar and cortical oxygenation and oxygen utilization all declined by furosemide administration after IR insult. Our study suggests that furosemide may cause additional structural and functional impairment to the kidney following ischemic injury and should be used with caution.
Recovering, correcting and reconstructing precipitation data affected by gaps and irregular readings: the Padua series from 1812 to 1864
Authors: Valle Antonio della , Camuffo Dario , Becherini Francesca , Zanini Valeria 
Published: September 2022

Abstract
The aim of this work is to reconstruct the 1812-1864 period of the Padua precipitation series, affected by some biases, e.g. missing readings and cumulative values, as in this period the observers did not follow a precise protocol: the measurements were not taken at specific hours of the day, it may happen that the raingauge was read after some days, cumulating rain, or even the precipitation was not recorded at all. Therefore, the daily amount and the frequency reported in the Log are not homogeneous with other periods, and need correction. The correction methodology has been based on the daily weather notes written in the Log in parallel to the readings. Taking advantage of the periods in which both weather observations and instrumental readings were regularly taken, the terms used to describe the precipitation type and intensity have been classified, analyzed statistically, calibrated, and transformed into numerical values. The weather notes allowed to distribute the cumulative amounts collected during some consecutive rainy days into the likely precipitation occurred in every single rainy day. In the case of missing readings, but in the presence of weather notes, the missing amounts have been estimated using the relationships found between precipitation types and amounts. Finally, the recovery of additional contemporary documents made it possible to fill some gaps of this period.
Gravitational folding of surface tension regions originates bio quantum path duality that quantizes Newtonian parameter value-driving inertia into parameter repetitiveness memory equivalent bio-inertia
Authors: Lai Yi Yu 
Published: September 2022

Abstract
Note: Please see pdf for full abstract with equations.
Inversion energy is defined as parameter-against-gravity-internal-fluctuation, quantizing time is internal fluctuation invariance conjugation of it inside a non-isolated environment. Newtonian Three Laws are modified as, first law: cosx = sinx = ; second law: + ; third law: Wavelength = L, frequency = n . Bio-systems are topological spaces that are capable of processing input objects into gravitational inversion energy for entropy-control by repetitiveness memory, the capability of equivalent procured inversion energy with memorized trigonometric curve repetitiveness is bio-inertia. Evolution is a process of accumulating trigonometric curve folding equivalent capacity inside space. Conventional Schrödinger equation has only quantized energy but still hasn’t quantized time thus inducing quantum collapse. We then conjugate inversion energy with quantizing time for lifespan. Originating from gravitational folding of surface tension regions, bio quantum path duality establishes in vivo cross folded-surface tension region-flow at diverse levels to drive evolution. Biofunctions from growth to consciousness revive from the elastic quantum duality that follows three modified laws.
Impact of Body Mass Index on Clinical Outcomes after Robotic Cardiac Surgery in Da Vinci: is There an Obesity Paradox?
Authors: Wu Wenjun , Ding Renzhong , Chen Jianming , Yuan Ye , Song Yi , Yan Manrong , Hu Yijie 
Published: September 2022

Abstract
Objective：To analyze the safety and efficacy of Da Vinci robotic cardiac surgery, to investigate the effect of body mass index (BMI) on postoperative clinical outcomes, and to explore the postoperative obesity paradox.
Methods：The data of 146 patients who underwent cardiac surgery under Da Vinci robotic cardiopulmonary bypass (CPB) from July 2016 to June 2022 in Daping Hospital of Army Medical University were retrospectively analyzed, and their demographic data and related clinical data were statistically analyzed. The mean age was (42.88±13.01) years, 55 (37.67%) were male and 91 (62.33%) were female. Patients were divided into 3 groups according to preoperative BMI: lean group (BMI<18.5 kg/m2; n=17; 11.64%), normal group (18.5 kg/m2≤BMI<23.9 kg/m2; n=81; 55.48%), and overweight and obese group (BMI≥24 kg/m2; n=48; 32.88%). Multivariate analysis was performed to compare clinical outcomes across BMI groups.
Results：Preoperative data in different BMI groups showed that there were statistically significant differences in gender, height, weight, body surface area (BSA), diabetes, left atrial anteroposterior diameter (LAD), triglyceride (TG), high-density lipoprotein (HDL), and lymphocyte count (LY) (all P<0.05). Postoperative clinical outcomes showed that the risk of cardiac surgery-associated acute kidney injury (CSA-AKI) was significantly increased in the overweight and obese groups (P=0.021), and further multivariate binary logistic regression analysis suggested that preoperative TG (OR 1.772, 95%CI 1.068-2.942,P=0.027) and operation time ≥ 300 min (OR 3.823, 95%CI 1.098-13.308,P=0.035) were independent risk factors for postoperative CSA-AKI.
Conclusion：Overweight and obese cardiac surgery is prone to CSA-AKI, which does not support the obesity paradox; preoperative TG and operation time≥300 min are independent risk factors for postoperative CSA-AKI.
Forewarning model of Glacial Lake Outburst Disaster in Southeast Tibet
Authors: Gao Jia , Du Jun , Ma Peng fei 
Published: September 2022

Abstract
The southeast region of Tibet was a frequent area of glacial lake outburst disasters, and disaster warning was an important means of disaster prevention and reduction. Based on remote sensing images and historical data, 21 Glacial Lakes in southeast Tibet were selected as samples for risk analysis. The probability model of glacial Lake Outburst in southeast Tibet is established by using the method of logistic regression for 8 selected prediction indexes. By calculating the sensitivity and specificity of the model, the probability of identifying the galcial Lake outburst event is 60% , and the identification degree of the galcial lake outburst is 86% . The AUC index area is obviously larger than 0.5, which indicates that logistic regression prediction plays a certain role in southeast Tibet. The probability equation of the model shows that the area of the Glacial Lake, the distance of the Glacial Lake from the glacier, the slope of the glacier, the slope of the glacier tongue and the slope of the water behind the dam are in direct proportion to the probability of the Glacial Lake Bursting, the more likely it is that the glacical lake will outburst, which is consistent with the observed facts.
Water Quality Assessment of Lake Burullus, Egypt, utilizing Statistical and GIS Modeling as Environmental Hydrology Applications
Authors: Mohsen Ahmed , Zeidan Bakenaz , Elshemy Mohamed 
Published: September 2022

Abstract
GIS is a very powerful tool for analyzing huge amount of data and connecting them with the geography, moreover recently there is great advancement in the field. The main objective of this study is to assess the water quality (WQ) and trophic status (TS) conditions of Lake Burullus, Egypt, using statistical modeling (PCA/FA & CA), WQ index (L-WQI) and trophic status index (Carlson TSI & TRIX) approaches, in addition to using GIS tools for building models able to automatically calculate the various indices and producing color coded maps for the lake. The results indicated that PCA/FA grouped the twenty-four WQ parameters into nine principal components explaining 72.6% of the total variance, domestic and agriculture pollution were dominant. CA divided the twelve sampling stations into most and least polluted groups. The lake WQ was classified as a “Very Poor”, according to L-WQI. Moreover, the results of the Carlson TSI and TRIX indices were coincided and classified the eutrophication levels in the lake as “Hyper-Eutrophic” and “Elevated Trophic”, respectively. Based on the results of this study, Lake Burullus needs urgent plans for recovering its WQ. Pre-treatment for its drains effluents and implementing of a periodical WQ monitoring program are highly recommended.
Impact of Behcet’s Disease on the Periodontitis and Gingivitis- A Case-Control Study
Authors: Orduyilmaz Fikriye , Ozmeric Nurdan , Elgun Serenay , Gürbüz Sühan , Kucuk Hamit , Bitik Berivan , Tufan Abdurrahman , Göker Berna 
Published: September 2022

AbstractObjective Behcet’s disease (BD) is a chronic ‘autoinflammatory’ disorder, characterized by the triad of oral and genital apthous ulcerations and iritis. We hypothesized that BD patients might have different immunological responses towards bacterial inflammation in their periodontal tissues due to their disease status, as well as medical treatment and this immunological differences might lead to clinical consequences. Materials and Methods Forty BD patients with gingivitis (BG) or periodontitis (BP) and 47 systemically healthy patients with either gingivitis (HG) or periodontitis (HP) were studied. Periodontal status was recorded with routine clinical indexes. Gingival crevicular fluid (GCF) and saliva samples were obtained. Nitric oxide (NO), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) levels were analyzed using colorimetric assay, EIA and ELISA. Current BD symptoms and medications usage were recorded. Results Mean probing pocket depths and clinical attachment levels were significantly lower in BG compared to HG subjects. Moreover, mean salivary IL-1β, TNF-α levels were elevated, and mean NO levels were decreased in BG compared to HG patients (p < 0.05 for IL-1β, TNF-α, p < 0.001 for NO). In contrast, mean NO levels in GCF were higher in BP group than in HP group (p < 0.01). While the BD patients with and without vascular involvement were compared, the salivary NO level was lower in patients with vascular involvement (p < 0.001). Conclusions Our results suggest that BD might have profound effects on the pathogenetic mechanisms of the gingivitis and periodontitis. Clinical Relevance The chronic inflammatory nature of both diseases, Behçet and periodontal disease, and the close relationship of proinflammatory cytokines with both disease activities suggested that there may be a bidirectional interaction between them.
Impact of COVID19 on clinical outcomes in hepatocellular carcinoma:A multicentre cohort study
Authors: De Souza Shuell , de Long Jeffery Kahol , Perone Ylenia , Shetty Shishir , Qurashi Maria , Jones Robert , Yip Vincent , Ross Paul , Bettinger Dominic , Reeves Helen , Geh Daniel , Sharma Rohini , Temperely Laura , Orr James , Banerjee Abhirup , Sturm Lukas , Shah Tahir , Allen Benjamin 
Published: September 2022

Abstract
Introduction:
The COVID-19 pandemic has caused severe disruption of healthcare services worldwide and interrupted patients’ access to essential services. During the first lockdown, many healthcare services were shut to all but emergencies. In this study, we aimed to determine the immediate and long-term indirect impact of COVID-19 health services utilisation on hepatocellular cancer (HCC) outcomes.
Methods
A prospective cohort study was conducted from March 1, 2020, until June 30, 2020 correlating to the first wave of the COVID-19 pandemic. Patients were enrolled from tertiary hospitals in the UK and Germany with dedicated HCC management services. All patients with current or past HCC who were discussed at a multidisciplinary meeting (MDM) were identified. Any delay to treatment (DTT) and the effect on survival at 1 year were reported.
Results
The median time to receipt of therapy following MDM discussion was 49 days. Patients with Barcelona Clinic Liver Cancer (BCLC) stages-A/B disease were more likely to experience DTT. Significant delays across all treatments for HCC were observed but delay was most marked for those undergoing curative therapies. Even though severe delays were observed in curative HCC treatments, this did not translate in reduced survival in patients.
Conclusion
Interruption of routine healthcare services because of the COVID-19 pandemic caused severe delays in HCC treatment. However, DTT did not translate to reduced survival. Longer follow is important given the delay to therapy in those receiving curative therapy.
The Economic Value of the Ecosystem Services of Wetlands in the Nile Basin: the Case of Lower Baro in Ethiopia and South Sudan
Authors: Tadesse Jemal A. , Mulatu Dawit W. , Yohannes Tinebeb , Akwany Leonard O. 
Published: September 2022

Abstract
South Sudan and Ethiopia, despite possessing many wetlands – some even having international importance, there has been limited attempts to value the ecosystem and biodiversity services of the wetlands. However, such valuation exercises are vital to promote knowledge-based decision making and the proper management of the wetlands. The Lower Baro wetlands systems is one of the wetlands in the Nile Basin located in both countries and among the wetlands with limited availability of literature; let alone valuation studies. This study is, hence, aimed at filling this gap and applied the Ecosystem Services Valuation Database (ESVD) to estimate the values of the ecosystem services since it was difficult to access the study area. The land use land cover map of the area was extracted using Remote Sensing and GIS tools. Considering 2020 as a base year, the annual economic value of the wetlands’ ecosystem services was estimated at above $660 million. More than half of these benefits emanate from the provisioning services while regulating and cultural services contribute about 22.5 percent each. The biodiversity services stood the least with less than half a percentage contribution. The findings reveal that the ESVD database is a good source of information for valuing wetlands in data scarce regions. Since the regulating and biodiversity services have a public good character, which may not be the immediate reasons for the conservation of the wetlands, actors from local to international levels should play their part in designing mechanisms for duly compensating local communities for these services.
Sulforaphane attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation
Authors: Shao Fang , Xie Yewen , Ding Jun , Pan Jie , Sun Xiao , Xia Lei , Qi Chunjian , Wang Shizhong , Zhu Dawei 
Published: September 2022

Abstract
Background
Sulforaphane (SFN) is a compound derived from cruciferous plants. It has received considerable attention in recent years due to its effectiveness in cancer prevention and anti-inflammatory properties. The purpose of this study was to evaluate the antitumor potential of sulforaphane on CAC through the establishment of a mouse model with AOM/DSS.
Methods
First, an AOM/DSS and DSS-induced model were established and administered SFN for 10 weeks, and then the severity of colitis-associated colon cancer was examined macroscopically and histologically. Subsequently, immune cells and cytokines in TME were quantified. Finally, the influence of sulforaphane was also investigated using different colon cell lines.
Results
We found that sulforaphane treatment decreased tumor volume, myeloid-derived suppressor cells (MDSC) expansion, the expression of the proinflammatory cytokine IL1β, and the level of IL-10 in serum. Also, it enhanced the antitumor activities of CD8 + T cells and significantly reduced tumorigenesis as induced by AOM/DSS. Sulforaphane also attenuated intestinal inflammation in DSS-treated mice. In vitro, sulforaphane reduced viability, blocked colon cancer cells in G2/M phase, enhanced the expression of Nrf-2 and HO-1, and increased intracellular reactive oxygen species (ROS) levels in colon cancer cells.
Conclusion
This work demonstrates that sulforaphane suppresses carcinogenesis-associated intestinal inflammation and prevents AOM/DSS-induced intestinal tumorigenesis and progression. These results call for further studies on sulforaphane as a natural agent for the prevention or treatment of colorectal cancer.
Coherent control of an ultrabright single spin in hexagonal boron nitride at room temperature
Authors: Guo Nai-Jie , Li Song , Yang Yuan-Ze , Zeng Xiao-Dong , Yu Shang , Meng Yu , Li Zhi-Peng , Wang Zhao-An , Xie Lin-ke , Ge Rong-Chun , Wang Jun-Feng , Li Qiang , Xu Jin-Shi , Liu Wei , Wang Yi-Tao , Tang Jian-Shun , Gali Adam , Li Chuan-Feng , Guo Guangcan 
Published: September 2022

Abstract
Hexagonal boron nitride (hBN) exhibits as the remarkable two-dimensional (2D) material to host solid-state spins, which has the great potential to be used in quantum information including quantum network. In this application, both the optical and spin properties are curcial for single spins, however, which nevertheless are not discovered simultaneously for hBN spins yet, e.g., the negatively charged boron-vacancy defect can be coherently controlled but is not isolated due to weak optical properties, and single-defect ODMR is detected but not shown to be coherently controllable. Here, we realize an efficient method to array and isolate the single defects of hBN and find a new spin defect. This single defect emits antibunching photons with ultrahigh emission rate reaching 25MHz (corrected) and Debye-Waller factor of 0.8, and possesses the optically-controllable spin (with narrow optically-detected-magnetic-resonance linewidth) indicated by significant Rabi-oscillation and Hahn-echo experiment at room temperature. First principles calculations indicate that complexes of carbon and oxygen dopants may be the origin of the single spin defects. The probability to find optically-detectable spins by our method is 85%, which gets 21-fold enhancement compared to the traditional methods. This provides the possibility to further address the spins that can be optically-controlled, since they only take 10.5% out of the optically-detectable spins.
Esophagectomy is possible with TAP! Avoid the epidural: A retrospective cohort review
Authors: Mitchell Will , Roser Thomas , Heard Jessica , Logarajah Shankar , Ok John , Jay John , Osman Houssam , Jeyarajah D. Rohan 
Published: September 2022

Abstract
Background: Esophagectomy traditionally has high levels of perioperative morbidity and mortality due to the surgical techniques and case complexity. While thoracic epidural analgesia (TEA) is considered first-line for postoperative analgesia after esophagectomy, there can be complications related to its sympathectomy and mobility impairment. Additionally, it has been shown that postoperative outcomes are improved with early extubation following esophagectomy. Our aim is to describe the impact of transversus abdominus plane (TAP) blocks on extubation rates following esophagectomy when uncoupled from TEA.
Methods: This is a retrospective study of 42 patients who underwent trans-hiatal esophagectomy between 2019 and 2022 who received a TAP block in the absence of TEA. The primary outcomes of interest were the rates of extubation within the operating room (OR) and reintubation. Secondary outcomes included: intensive care unit (ICU) and hospital length of stay (LOS), opioid pain medication use, time to enteral diet, reported postoperative pain scores, development of anastomotic leak, and 30-day readmission.
Results: The mean age at operation was 63 years and 97.6% of patients were represented by American Society of Anesthesia (ASA) physical status class III or IV. 35 (83.3%) patients immediately extubated postoperatively. Nine patients (21.4%) underwent reintubation during their hospital course. Only six patients (14%) required vasopressors postoperatively. The median LOS was five days in the ICU and 10 days in the hospital. TAP block alone was found to be equivalent to TAP with additional regional blocks (TAP+) on the basis of immediate extubation, reintubation, ICU and hospital LOS, and reported postoperative pain.
Conclusion: The results of this study demonstrate TAP blocks do provide comparable rates of successful immediate extubation and reintubation to TEA with fewer hypotensive complications after trans-hiatal esophagectomy. This was shown despite the elevated comorbidity burden of this study’s population. Additionally, TAP blocks maintained similar reported pain control scores to TEA literature.Overall, this study supports the use of TAP blocks as the primary analgesia in patients undergoing trans-hiatal esophagectomy over TEA.
Trial Registration: This study includes participants who were retrospectively registered. IRB# 037.HPB.2018.R