bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is important for people with type 2 diabetes? A focus group study to identify relevant aspects for Patient-Reported Outcome Measures in diabetes care
Authors: Abdel-Rahman Nura , Manor Orly , Valinsky Liora , Mosenzon Ofri , Calderon-Margalit Ronit , Roberman Sveta 
Published: November 2022

Background
Patient-Reported Outcome Measures (PROMs) aim to evaluate the quality of care based on the perspectives of patients rather than clinical indicators. Qualitative research is needed to identify these perspectives in people with type 2 diabetes.

Objective
To identify, for the first time in Israel, aspects valuable for people with type 2 diabetes that can be relevant for PROMs in diabetes care.

Methods
A qualitative study included three focus groups totalling 19 people with type 2 diabetes. Inclusion criteria were: (1)type 2 diabetes, (2)diabetes duration of at least six months, and (3)adults aged 45–80 years. Purposive sampling enabled recruitment of heterogeneous participants. Also, two experts’ panels with healthcare providers involved in diabetes care (n = 23) were conducted to provide triangulation of information (more testimony about what is valuable for people with type 2 diabetes). Discussions were recorded, transcribed and thematically analysed.

Results
Four domains were deemed valuable for people with type 2 diabetes: (1)challenges of living with diabetes, including reduced physical function, healthy lifestyle struggles, sexual dysfunction, and financial burden, (2)mental health issues, including depression, distress, anxiety, frustration, and loneliness, (3)self-management ability, including management of lifestyle modifications and treatment, knowledge about the disease and treatment, and (4)patient-clinician relationships, including the devotion of clinicians, trust in clinicians and treatment, shared decision-making, and multidisciplinary care under one roof. Experts favour using PROMs in diabetes routine care and even acknowledged their necessity to improve the treatment process. However, only some of the domains raised by people with type 2 diabetes were identified by the experts.

Conclusions
There are content gaps between perspectives of people with type 2 diabetes and their healthcare providers. PROMs are essential in addressing issues largely not addressed in routine diabetes care. We recommend that researchers and healthcare providers, who intend to utilize PROMs for diabetes care, consider the aforementioned domains.
Predictors of sputum culture conversion time among MDR/RR TB patients on treatment in a low-income setting
Authors: Meshesha Meiraf Daniel 
Published: November 2022

Objective
This study aimed to assess the time to first culture conversion and its predictors among MDR/RR-TB cases enrolled in Dilchora Hospital.

Method
A retrospective cohort study was conducted among MDR/RR TB cases enrolled between January 2014 and December 2018. SPSS version 26 was used for analysis. Reports are presented using percentages and frequency. Independent predictors of time-to-culture conversion were identified using multivariate Cox proportional hazard regression. Adjusted and crude hazard ratio with 95% CI was used. P-value< 0.05 declared statistical significance.

Result
A total of 145 MDR/RR TB cases were included. The median time to culture conversion was at 2 months. Higher baseline hemoglobin [AHR:1.101(1.02–1.19)] and having a non-cavitary lesion on chest x-ray[AHR:1.803(1.15–2.83)] predicted a higher likelihood of early culture conversion. Resistance to at least one first-line anti-TB drug in addition to rifampicin was associated with a lower hazard of early culture conversion as compared to only rifampicin resistance[AHR: 0.577(0.37–0.91)].

Conclusion & recommendation
A baseline hemoglobin level, chest x-ray finding of cavitation and resistance to rifampicin, and at least one additional drug predicted the time to culture conversion. A closer treatment monitoring and follow-up should be emphasized for those presenting with lower baseline hemoglobin, more drug resistance, and cavitation on chest x-ray.
PENGEMBANGAN MODEL PERSEDIAAN ECONOMIC ORDER QUANTITY MULTI ITEM DENGAN MEMPERTIMBANGKAN FAKTOR KADALUARSA, ALL UNIT DISCOUNT, DAN KENDALA KAPASITAS
Authors: Silitonga Roland Y. H. , Julieta Celia Esterina 
Published: November 2022

Jenis usaha produk konsumsi seperti minimarket biasanya menjual beberapa jenis produk dengan volume yang rendah dan memiliki fluktuasi permintaan yang cenderung kecil. Terdapat tiga hal yang perlu diperhatikan dalam mengendalikan persediaan pada minimarket, yaitu kemungkinan untuk mendapatkan potongan harga jika membeli bahan makanan dalam jumlah besar, barang konsumsi yang dapat kadaluarsa,, serta adanya keterbatasan kapasitas yang dimiliki. Tujuan dari penelitian ini adalah mengembangkan model persediaan economic order quantity multi item dengan mempertimbangkan faktor kadaluarsa, all unit discount, dan kendala kapasitas. Pengembangan model dilakukan dengan cara mengembangkan model persediaan economic order quantity multi item dengan mempertimbangkan kadaluarsa dan all unit discount dari model terdahulu, lalu dilanjutkan dengan mengembangkan faktor kendala kapasitas menggunakan persamaan proporsi permintaan produk. Model yang telah dikembangkan akan diuji coba dengan melakukan perubahan pada nilai parameter model untuk melihat sensitivitasnya. Dari hasil analisis sensitivitas yang telah dilakukan, ditemukan bahwa total biaya persediaan sensitif terhadap harga beli satuan barang. Sedangkan, waktu pemesanan sensitif terhadap perubahan kapasitas gudang. Abstract[Development of Economic Order Quantity Multi Item Inventory Model by Considering Perishable Factor, All Unit Discount, and Capacity Constraint] Types of consumer product businesses such as minimarkets usually sell several types of products with low volumes and tend to have small fluctuations in demand. There are three things that need to be considered in controlling inventory at minimarkets, namely the possibility of getting a discount if you buy food in bulk, consumer goods that can expire, and the limited capacity they have. The purpose of this study is to develop a multi-item economic order quantity inventory model by considering expiration factors, all unit discounts, and capacity constraints. Model development is carried out by developing a multi-item economic order quantity inventory model by considering expiration and all unit discounts from the previous model, then proceeding to develop a capacity constraint factor using the product demand proportion equation. The developed model will be tested by making changes to the model parameter values to see its sensitivity. From the results of the sensitivity analysis that has been carried out, it was found that the total cost of inventory is sensitive to the unit purchase price of goods. Meanwhile, the time of ordering is sensitive to changes in warehouse capacity.Keywords: economic order quantity; multi item; perishable; all unit discount; capacity constraint.
Program Začít spolu jako inovace měnící tvář českého školství
Authors: Poche Kargerová Jana , Seberová Alena , Váňová Krejčová Věra 
Published: November 2022

Cílem diskusního příspěvku je analyticky reflektovat vývoj a zejména přínos vzdělávacího programu Začít spolu na poli inovací preprimárního a primárního vzdělávání v České republice. Záměrem je nejen popsat konkrétní kvalitativní změny, které program vnesl a vnáší do každodenní pedagogické praxe škol, ale rovněž zachytit dopady implementace programu Začít spolu na širší terén kurikulární reformy a kvality učitelské profese.
Immunology of Modern Society Humans [IMSH]
Authors: Shnawa Ibrahim M. S. 
Published: November 2022

Humans lives in modern society are subjected to an array of factors that impacts the cellularity and functionality of their immune systems. These IMSH factors were ensemble as; Global changes, liberal spread of mental influencing drugs, war warfare ,terrorism ,environmental mutagens and carcinogens as well as environmental allergens .So they are being at risk for both enhancing or dampening effects on their immune systems. Workers have been documenting four main categories of targeted human immune system living at risk of modern society .The IMSH categories are; intravenous drug users, intensive care patients, tumor patients , war warfare and terrorism. The intravenous drug users have shown increase in their humoral B cell immune responses through the elevation of B cell counts and activities and increase in activation markers of T cell subsets. Intensive care patients were mainly showing functionality of cellular immunity like that of ageing immune cells. Tumor patients, however, were found expressing diversity and compositional heterogeneity of immune cell type reaching 33 subsets and marked functional alterations. Tumor microenvironment have shown at least six dominant pan-cancer-classes of dominant immune cells as compared to normal human subjects immune cellularity. Biological warfare and bioterrorism insults were being accompanied by emergence and re-emergence of unfamiliar agent pathogenicity ,seasonality and marked host susceptibility to the terrorism agent necessary need for individual therapy and management ,as well as for pre and post exposure mass vaccination .Each IMSH category have expressed shared and distinctive features. The unified functional insight to the immune systems of human living in modern society is that formed cellular elements of these immune systems behave to different insults in different ways and different elements reacts differently to the same insult.
Death Inequality During the First Year of Life in Morocco: A Macro Level Analysis
Authors: LOUDGHIRI Khadija , BAKASS Fatima , FAZOUANE Abdesselam 
Published: November 2022

Disparities in child mortality are a reality in Morocco. These disparities coexist with inequalities in: (i) the availability of primary health care (PHCs); (ii) the socioeconomic status of the population as reflected by the prevalence of various forms of poverty; as well as (iii) fertility levels (TFRs) and the status of women in literacy and employment rates. Despite its limitations, this research provides a macro-level understanding of the link between infant mortality and a range of aggregates (political, economic, social and demographic).The metadata collected in the 2014 census (RGPH-2014) RGPH-2014 was used to construct a provincial proxy indicator of infant mortality by area of residence.This is considered as a dependent variable that we have tried to explain by the above-mentioned indicators. This is considered as a dependent variable that we have tried to explain by the above-mentioned indicators. The latter indicators reflect the socio-economic conditions prevailing in each of the provinces by area of residence. In addition, they give information on the availability of basic health services and on the woman's status. A key finding is that the level of current fertility as measured by the TFR negatively affects child survival. With a statistically significant regression coefficient of 2.912 (Pvalue =0.000), it can be argued that high fertility increases the risk of infant mortality. In turn, the prevalence of overall poverty also has a statistically significant effect on infant survival (β= -0.213 with a pvalue =0.029).
Assessment of drought tolerance indices in faba bean genotypes under different irrigation regimes
Authors: Abdelhaleim Manal S. , Rahimi Mehdi , Okasha Salah A. 
Published: November 2022

Abstract
Drought stress has devastating impacts on faba bean production, particularly with the current abrupt climate changes in arid environments. Hence, it is essential to identify drought-tolerant genotypes. The present study aimed at assessing six faba bean genotypes under three irrigation levels during two winter successive growing seasons (2018/2019 and 2019/2020). The applied irrigation levels were well-watered (every 4 days (D1), moderate drought every 8 days (D2), and severe drought 12 days (D3)) regimes. The analysis of variance exhibited highly significant differences among genotypes, irrigation treatments, and their interactions for all studied traits, except the number of pods plant−1 in the first season. Yield traits of all assessed genotypes decreased significantly with increasing drought stress. Otherwise, proline content (Pro) increased significantly with increasing drought stress. The genotypes Giza.843, Nubaria.2, and Nubaria.3 recorded the highest values of plant height, number of branches/plant, pods/plant, pods weight/plant, 100 seed weight, seed yield/plant, and seed yield/kg under drought stress. Similarly, the highest Pro was displayed by Giza.843 and Nubaria.3 under drought stress in both seasons. Furthermore, Giza.843, Nubaria.2, and Nubaria.3 genotypes had the highest values for most tolerant indices. Accordingly, these genotypes could be exploited in developing drought-tolerant and high-yielding faba bean genotypes in arid environments through breeding programs.
Aquaporin-8 overexpression is involved in vascular structure and function changes in placentas of gestational diabetes mellitus patients
Authors: Shan Yanxing , Cui Jiawen , Kang Xinyi , Tang Weichun , Lu Yiling , Gao Ying , Chen Liping 
Published: November 2022

Abstract
To study the role and mechanism of aquaporin-8 (AQP8) in placental vascular development in gestational diabetes mellitus (GDM), hematoxylin–eosin staining and immunohistochemistry were utilized to analyze the histopathological changes in placentas in GDM patients. Transwell, CCK-8, and tube formation assays were performed to examine cell migration, proliferation, and tube formation. AQP8, vascular cell adhesion molecule 1 (VCAM-1), tumor necrosis factor alpha (TNF)-α, and vascular endothelial growth factor (VEGF)-A expression levels were investigated. Relative to the control group, the placentas in the GDM group showed morphological changes, the number of microvessels in the placental villi arterioles was significantly higher, and the area of microvessels in the arterioles of placental villi was significantly lower. The expression levels of VCAM-1, TNF-α, VEGF-A, and AQP8 in the GDM placentas and human umbilical vein endothelial cells (HUVECs) stimulated by high glucose were significantly higher than those in the control group, and AQP8 was located in placental endothelial cells. Overexpression of glucose and AQP8 inhibited tube formation, migration, and proliferation in HUVECs. High glucose levels can induce dysfunction in vascular endothelial cells and lead to pathological changes in the placental vascular structure in GDM. AQP8 overexpression in placental GDM can inhibit endothelial cell behavior, cause endothelial cell dysfunction, and further participate in the occurrence and development of GDM placental vascular lesions.
Archaeological culture, document texts, and the construction of early Wu Yue history
Authors: Xu Lianggao 
Published: November 2022

Abstract
The current study first systematically traces the archaeological cultures of southeast China (the Wu Yue region) during the Western Zhou, from the perspective of material culture remains, sources, regional variants, and social conditions revealed from the archaeological evidence. It then analyzes the plurality of interpretations of bronze inscriptions and the nature of documentary records concerning the emergence of the Wu and Yue states and their early history. The author points out that a regional archaeological culture with unique characteristics, showing great cultural affinity with the Wu Yue culture during the late Eastern Zhou period (771–475 BCE) had existed in southeast China during Western Zhou (1045–771 BCE). However, the emergence of Wu and Yue states and their early history recorded in historical texts have not been confirmed by any archaeological discoveries in the form of material cultures, bronze inscriptions, or documentary texts. Assertions of direct connections between related archaeological cultures and early Wu and Yue states lack persuasiveness. Considering this, the author proposes new insights into the textuality of documentary records, the relation between archaeology and historical texts, as well as the essence of historiography.
2021 年度华语研究综述
Authors: 月丽 卢 
Published: November 2022

Abstract
In 2021, Huayu study has been expanded and deepened at the ontology and application levels, and has achieved fruitful results. The former shows that the situation of more synchronic research and less diachronic research has improved. While the synchronic research has increased steadily, a lot of diachronic research has been added; the latter has carried out a series of researches on important topics such as Chinese teaching and Huayu planning. On the whole, the research content is more abundant, the scope is expanded, and the perspectives tend to be diversified. However, this year’s Huayu studies are still relatively weak in some aspects, such as Huayu theoretical construction and empirical research. In addition, the construction and application of Huayu corpus have begun to receive great attention, which may become the future trend of Huayu study.
“Brown hare never goes underground”: the exception that proves the rule
Authors: Pecorella Stefano , Mori Emiliano 
Published: November 2022

AbstractAmongst leporids, rabbits use underground warrens as resting and reproductive sites, whereas hares usually rests in soil depressions in woodlands or scrublands, providing them with cover and protection from predators. In this short communication, we reported for the first time the use of badger burrows as resting sites of the European brown hareLepus europaeusin North-Eastern Italy. Underground dens may provide hares with the best cover from daylight and protection from both predators and bad weather conditions.
Erector spinae plane blocks for day-case medical thoracoscopy: a pilot clinical study
Authors: McPherson Jamie , Halvey Edward , Aujayeb Avinash 
Published: November 2022

AbstractObjectivesErector spinae plane (ESP) blocks are a regional anaesthetic technique used for pain relief in thoracic procedures. Our centre has recently begun using ESP blocks pre-medical thoracoscopy for analgesia.MethodsNine patients undergoing MT from September 2021 to February 2022 were included. Opioid use and depth of required sedation was recorded. Pre and post pain scores and at home were recorded by interview and review of charts. A functional pain questionnaire was administered via telephone.ResultsAverage greatest depth of sedation using propofol was 1.92 (standard error of mean [SEM] 0.27), with remifentanil 2.52 (SEM 0.46). 78% required oral analgesia on day 0 post discharge. 55% required oral analgesia on post-op day 1. Patients used an average of 3.33 mg oral morphine (SEM 2.35) in hospital, and 3 mg (SEM 2) on post-op day 1. Periprocedural pain scores were 0.66 (SEM 0.27). Pain scores in recovery were 1.56 (SEM 0.76). Pain scores 3–12 h post discharge were 3.56 (SEM 0.7), while pain scores on post-op day 1 were significantly higher at 5.56 (SEM 0.90) (Figure 1). Functional pain scoring showed patients doing activities of daily living well with a good ability to breathe and cough. All felt that their pain was well controlled on the day of the procedure and at home. No complications were reported.ConclusionsESP blocks provide good analgesia. Pain scores showed significant analgesic effect lasting several hours. The project showed pain outcomes and patient acceptability were good for the use of regional anaesthesia.
Effect of the manufacturing process on the equivalency qualification of glass fiber reinforced polymer
Authors: Kim Dong-Chul , Choi Jeoung Sik , Shin Hyo-Soon , Jung InKyun , Heo Young Woo 
Published: November 2022

Abstract
Glass Fiber Reinforced Polymer (GFRP) is widely used as aerospace material requiring high specific strength, specific stiffness, and excellent mechanical and chemical properties. To apply the already approved composite materials to other processes, an equivalency test that compares the mechanical properties of the composite materials based on the database is required. For the successful completion of the equivalency test, it is important to control the factors affecting the mechanical properties. The resin content and density of the specimens are manufactured differently according to the process. The effect of these factors on the change of mechanical properties required for equivalency qualification has not been sufficiently reported. In this study, an equivalency test was performed on the GFRP applied to the aircraft radome based on the procedure of the equivalency test and acceptance test proposed by the National Center for Advanced Materials Performance. The causes of problems occurring between equivalency tests were analyzed. It was confirmed that the resin content, density, and voids of the specimen affect the mechanical properties. As the resin content decreases, the density and voids were controlled, and it was confirmed that the average strength and modulus increase by 13.12 and 6.78%, respectively. The equivalency qualification was completed by applying an improved process in which these factors were controlled.
Extracellular vesicles from seminal plasma to improve fertilizing capacity of bulls
Authors: Lange-Consiglio Anna , Capra Emanuele , Monferini Noemi , Canesi Simone , Bosi Giampaolo , Cretich Marina , Frigerio Roberto , Galbiati Valentina , Bertuzzo Federica , Cobalchini Francesco , Cremonesi Fausto , Gasparrini Bianca 
Published: November 2022

Extracellular vesicles (EVs) contained in seminal plasma, vehicle RNA, proteins, and other molecules able to influence the biological function of sperm. The aim of this study was to improve the fertilizing capacity of male gametes of low-fertility bulls using EVs isolated by ultracentrifugation from the seminal plasma of a bull of proven fertility. After a dose–response curve study, 10×106 sperm of low-fertility bulls were co-incubated for 1 h with 400×106 EVs/mL. In addition, it has been verified that the incorporation of EVs, which takes place in the sperm midpiece, is maintained for 5 h and even after cryopreservation. Subsequently, the spermatozoa of low-fertility bulls, with EVs incorporated, were used for the in vitro production of embryos. The rate of blastocyst at seventh day yield in vitro, with the use of sperm with EVs incorporated, increased by about twice the yield obtained with the same sperm in the absence of EVs: bulls having an average embryonic yield of 6.41 ± 1.48%, 10.32 ± 4.34%, and 10.92 ± 0.95% improved their yield to 21.21 ± 1.99%, 22.17 ± 6.09%, and 19.99 ± 5.78%, respectively (P < 0.05). These encouraging results suggest that it might be possible to keep breeding bulls with poor fertility. Further studies will be needed to evaluate the in vivo fertility of sperm treated with EVs and understand how the content of EVs is involve in the sperm–vesicle interaction and in the improved sperm performance.

Lay summary
Sperm can fertilize eggs after they mature as they move through the tube in the testes. As they move, the sperm communicate with the lining of the tubes, thanks to small sacs which are made by the tube itself. These sacs contain many molecules that may play a part in the mechanisms that help sperm fertilize eggs. In veterinary medicine, as with humans, there are fertile and less-fertile individuals. It is possible that the sacs of the semen from a bull which is known to be fertile are different to those from a bull with low fertility. For this reason, sacs from bulls with proven fertility were mixed with sperm from the less-fertile bulls to test in the laboratory how the sperm was able to fertilize eggs and produce embryos. The results show that, in the laboratory, the number of embryos produced is doubled. This suggests it would be possible to improve the fertility of people who are less fertile.