bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPORTÂNCIA DA ATIVAÇÃO DO SISTEMA COMPLEMENTO PARA A RESPOSTA IMUNOLÓGICA
Authors: Santos Leticia brito dos 
Published: July 2022

Introdução: Além das defesas das células do sistema imune inato, o nosso organismo conta com o sistema complemento com o propósito de potencializar a resposta imunológica, composto por proteínas produzidas pelas células hepáticas. Essas proteínas denominadas como prefixo C variando de 1 a 9, quando ativadas em cascata são capazes de iniciar uma resposta inflamatória e causar a morte do patógeno. Objetivo: Abordar os principais mecanismos de ativação do sistema complemento, e sua importância na defesa imunológica. Metodologia: Foi utilizado a metodologia descritiva e explicativa, visando compreender a fisiologia do sistema complemento. Resultado: Existem três vias de ativação do sistema complemento: a via clássica, depende da ligação do complexo C1 qrs com anticorpos que se ligam a microrganismos, se tornando um componente humoral da imunidade adaptativa, já a via alternativa atua sem a interação antígeno anticorpo ,iniciada com a molécula c3b, é deflagrada quando proteínas são ativadas em superfícies microbianas, por último a via lectina, é iniciada com a lectina ligadora de manose liga-se aos carboidratos de microrganismos. Esse sistema cumpre três passos: a opsonização: a porção C3b recobre o antígeno deixando-o marcados para serem fagocitados pelas células com receptores próprios. Inflamação: os fragmentos proteolíticos C5 e C3, recrutam leucócitos e proteínas plasmáticas gerando inflamação. Lise celular: A ativação da cascata culmina um complexo proteico polimérico na membrana microbiana ocasionando lise celular. Além dessas proteínas proteolíticas, outras proteínas estão envolvidas na defesa imune contra infecção, como a proteína c reativa que se liga a fosforicolina dos microrganismos opsonizando-os para serem fagocitados e também podendo ativar proteínas da via clássica, considerando um dos principais marcadores clínicos de infecção da fase aguda. Conclusão: Portanto, a ativação do sistema complemento é de extrema importância pois apesar do reconhecimento de patógenos ser um mecanismo de resposta inata, também participa da imunidade humoral adaptativa para exterminar o agente invasor.
FASES DA LEUCEMIA MIELÓIDE CRÔNICA PARA AUXÍLIO DE UM DIAGNÓSTICO PRECOCE.
Authors: Jesus Dyessica kerolaine Oliveira de , MARTINELLI ARIELLA , SOUZA CAMILA DE , CAMPOS CÁSSIA CALIXTO DE 
Published: July 2022

Introdução: A leucemia mielóide crônica (LMC) se dá pela presença de uma numerosa quantidade de células da linhagem mielóide presente no sangue e na medula, e geralmente se manifesta em adultos entre 40 a 60 anos. Está leucemia é comumente desenvolvida por uma anormalidade genética devido a translocação entre os cromossomos 9 e 22, desenvolvendo um cromossomo conhecido como Philadelphia (Ph+). Contudo, pode-se também existir pacientes com Philadelphia negativo (Ph-). A LMC pode ser apresentada em fase crônica, acelerada e crise blástica que é a pior das fases. Objetivo: Este trabalho propõe disseminar o conhecimento sobre as fases da doença de maneira a traçar pontos estratégico para um diagnóstico precoce. Metodologia: Este trabalho trata-se de Revisão literária Narrativa, na qual trás uma analise critica pessoal do autor sobre o tema e NÃO se aplica critérios de elegibilidade. As fontes para pesquisa foram site da OMS, Scielo e Google acadêmico utilizando palavra como Leucemia e leucemia Mielóide Crônica dos últimos 5 anos. Resultados: A LMC tem desenvolvimento lento e pode levar a redução de qualidade de vida do paciente e até mesmo ao óbito se não diagnosticado e tratada corretamente. Existem 3 fases distintas nesta doença: A Fase crônica: a qual acontece a proliferação clonal maciça das células; a fase acelerada: a qual o clone perde sua capacidade de diferenciação celular e a fase blástica: que é a mais agressiva na qual o perfil celular é totalmente imaturo no paciente. O diagnóstico da doença poderia ser realizado em fases iniciais através do hemograma e confirmação com exames citogenéticos. Contudo, é necessário que o profissional esteja atento e tenha conhecimento sobre a fisiopatologia e as fases da doença. Conclusão: É de extrema importância que os profissionais da área da Analises Clinicas em Hematologia entendam os mecanismos fisiopatológicos das patologias envolvidas nas células sanguíneas e dominem os exames para que possam saber interpreta-los de maneira sensitiva a quaisquer alterações, por menor que seja, e inicie um start investigativo nestes profissionais que leve ao auxilio do diagnóstico correto e precoce das doenças.
A INFLUÊNCIA DOS GLICOCORTICOIDES NO RESULTADO DE EXAMES LABORATORIAIS.
Authors: CUNHA EDNA MARIA SILVA DA , ABREU FERNANDA  VERDINI GUIMARÃES , HEINEN RENATA CORRÊA 
Published: July 2022

Introdução: Os glicocorticoides são anti-inflamatórios esteroidais que são utilizados em episódios agudos de inflamação e em doenças autoimunes, com o intuito de reduzir a resposta imunológica. O uso desta classe de medicamentos está relacionado a uma série de alterações metabólicas no organismo, podendo interferir nos níveis de glicose, lipídios e eletrólitos no sangue e na urina, deste modo, eles podem provocar alterações durante a realização de exames bioquímicos. Objetivos: Este trabalho apresentou como objetivo a realização de uma revisão bibliográfica sobre os possíveis erros em resultados de exames laboratoriais mediante ao uso de glicocorticoides pelo paciente. Metodologia: Este é um estudo de revisão bibliográfica, onde foram utilizados sites de busca, como PUBMED e SCIELO, através das palavras-chave: glicocorticoides, efeitos adversos dos glicocorticoides, alterações bioquímicas provocadas por glicocorticoides. Resultados: Mediante ao apanhado de informações obtidas neste estudo, foi possível observar que uso de glicocorticoides pode promover alteração no quantitativo de células sanguíneas como leucócitos, plaquetas e hemácias além de interferências nos níveis de hemoglobina e hematócritos. Também foi notado a possibilidade de aumento nos níveis séricos de glicose e sódio e redução nos níveis séricos de potássio e de cálcio. Sobre o perfil lipídico, os glicocorticoides podem provocar aumento nos níveis séricos de colesterol total, LDL- C e triglicerídeos. Conclusão: Concluiu-se então que é importante saber se o paciente que irá ser submetido a um exame laboratorial está fazendo uso de glicocorticoides, uma vez que estes medicamentos podem alterar o resultado de diversos exames, gerando equívocos em diagnósticos. Portanto, faz-se necessária a educação continuada sobre as interferências de medicamentos nos exames laboratoriais, destacando a importância da fase pré-analítica, onde o paciente deve passar por uma série de questionamentos sobre hábitos diários que possam prejudicar a análise final.
The impact of aerosol fluorescence on long-term water vapor monitoring by Raman lidar and evaluation of a potential correction method
Authors: Chouza Fernando , Leblanc Thierry , Brewer Mark , Wang Patrick , Martucci Giovanni , Haefele Alexander , Vérèmes Hélène , Duflot Valentin , Payen Guillaume , Keckhut Philippe 
Published: July 2022

Abstract. The impact of aerosol fluorescence on the measurement of water vapor by UV (355 nm emission) Raman lidar in the upper troposphere and
lower stratosphere (UTLS) is investigated using the long-term records of
three high-performance Raman lidars contributing to the Network for the
Detection of Atmospheric Composition Change (NDACC). Comparisons with
co-located radiosondes and aerosol backscatter profiles indicate that
laser-induced aerosol fluorescence in smoke layers injected into the
stratosphere by pyrocumulus events can introduce very large and chronic wet
biases above 15 km, thus impacting on the ability of these systems to
accurately estimate long-term water vapor trends in the UTLS. In order to mitigate the fluorescence contamination, a correction method
based on the addition of an aerosol fluorescence channel was developed and
tested on the water vapor Raman lidar TMWAL located at the JPL Table Mountain Facility in California. The results of this experiment, conducted
between 27 August and 4 November 2021 and involving 22 co-located lidar and
radiosonde profiles, suggest that the proposed correction method is able to
effectively reduce the fluorescence-induced wet bias. After correction, the average difference between the lidar and co-located radiosonde water vapor measurements was reduced to 5 %, consistent with the difference observed during periods of negligible aerosol fluorescence interference. The present results provide confidence that after a correction is applied,
long-term water vapor trends can be reasonably well estimated in the upper
troposphere, but they also call for further refinements or use of
alternate Raman lidar approaches (e.g., 308 nm or 532 nm emission) to
confidently detect long-term trends in the lower stratosphere. These
findings may have important implications for NDACC's water vapor measurement strategy in the years to come.
Advance prediction of coastal groundwater levels with temporal convolutional network
Authors: Zhang Xiaoying , Dong Fan , Chen Guangquan , Dai Zhenxue 
Published: July 2022

Abstract. Prediction of groundwater level is of immense importance and challenges for the coastal aquifer management with rapidly increasing climatic change. With the development of artificial intelligence, the data driven models have been widely adopted in predicting hydrological processes. However, due to the limitation of network framework and construction, they are mostly adopted to produce only one-time step in advance. Here, a TCN-based model is developed to predict groundwater level variations with different leading periods in a coastal aquifer. The historical precipitation and tidal level data are incorporated as input data. The first hourly-monitored ten-month data were used for model training and testing, and the data of the following three months were predicted with 24, 72, 18 and 360 time steps in advance. For one-step prediction of the two wells, the calculated R2 are higher than 0.999 in the prediction stage. The performance is meanwhile compared with a powerful network in the field of time-series prediction, long short-term memory (LSTM) recurrent network. The corresponding R2 of the LSTM-based model are 0.996 and 0.998. While the RMSE values of TCN-based model are less than that of LSTM-based model with shorter running times. For the advanced prediction, the model accuracy greatly decreases with the increase of advancing period from 1-day to 3-, 7- and 15-days. Overall, the TCN- and LSTM-based models show great ability to learn complex patterns in advance using historical data within the time series. Considering the simulation accuracy and efficiency, the TCN-based model outperforms the LSTM-based model and has been proved to be a valid localized groundwater prediction tool in the subsurface environment.
IMPLEMENTASI PENILAIAN BERBASIS KELAS DALAM PEMBELAJARAN IPA BERBASIS INQUIRI DI SMP NEGERI 4 MUARA BUNGO
Authors: Fitri Elda 
Published: July 2022

Penelitian ini bertujuan untuk meningkatan kompetensi dasar siswa pada mata pelajaran IPA pada pokok bahasan gerak benda dan makhluk hidup di lingkungan sekitar melalui implementasi penilaian berbasis kelas dalam pembelajaran IPA berbasis inquiri. Jenis penelitian ini adalah penelitian tindakan kelas, yang terdiri dari dua siklus. Masing-masing siklus terdiri dari empat tahapan, yaitu rencana tindakan, pelaksanaan tindakan, observasi/evaluasi, dan refleksi. Penelitian ini dilaksanakan di kelas VIII.5 SMP Negeri 4 Muara Bungo dengan melibatkan 30 orang siswa tahun pelajaran 2021/2022. Data tentang kompetensi kognitif siswa dikumpulkan dengan metode tes, data tentang kompetensi afektif siswa dikumpulkan dengan metode observasi, data tentang kompetensi psikomotor siswa dikumpulkan dengan metode observasi. Selanjutnya data dianalisis secara deskriptif. Temuan penelitian ini menunjukkan bahwa (1) terjadi peningkatan kompetensi kognitif siswa dari nilai rata-rata 69,80 dengan ketuntasan belajar klasikal 53,85% pada siklus I menjadi nilai rata-rata 77,40 dengan ketuntasan belajar klasikal 87,18% pada siklus II, (2) terjadi peningkatan kompetensi afektif siswa dari nilai rata-rata 80,30 dengan kategori baik pada siklus I menjadi nilai rata-rata 84,90 dengan kategori sangat baik pada siklus II, dan (3) terjadi peningkatan kompetensi psikomotor siswa dari nilai rata-rata 66,40 dengan kategori cukup pada siklus I menjadi nilai rata-rata 77,18 dengan kategori baik pada siklus II.
Features of gestational period and perinatal outcomes in women with insulin resistance
Authors: Bаymatova Z. K. , Oripova Sh. N. , Mulkamonova L. N. , Talbova N. S. , Kurbanova P. Z. 
Published: July 2022

Aim. To study the course of pregnancy and perinatal outcomes in women with insulin resistance. Material and methods. A retrospective and prospective study of 102 women and their newborns who were born in the State Institution “Research Institute of Obstetrics, Gynecology, and Perinatology” for the period 2017-2019 was conducted. All pregnant women were divided into 3 groups according to the level of insulin resistance index (NOMA index). Group I - 42 pregnant women with developmental risk factors for diabetes with an insulin resistance index above 2.84. Group II consisted of 30 subjects with a NOMA index below 2.21, and Group III (n = 30) consisted of healthy pregnant women with a physiological course of pregnancy and labor. Results. Newborns born to women with a NOMA index above 2.84 (pathological insulin resistance) have a high incidence of perinatal complications: central nervous system defects, various degrees of asphyxia, hypotrophy, and immaturity. Conclusion. Insulin resistance in general affects pregnancy and has a negative impact on the course of pregnancy, causing a high incidence of complications such as threatened miscarriage, preeclampsia, chronic placental insufficiency and affecting perinatal outcomes.
Relaparotomy and repeated minimally invasive interventions in hepatobiliary surgery
Authors: Makhmadov F. I. , Sadulloev D. N. , Murodov A. I. , Ashurov A. S. , Safarov F. Sh. , Najmudinov F. N. 
Published: July 2022

Aim. To improve the immediate results of surgical treatment of injuries, and diseases of the liver and biliary tract through the rational use of minimally invasive technologies. Material and methods. Over the past 18 years, 6548 surgical interventions on the liver and biliary tract were performed. Postoperative intra-abdominal complications were observed in 643 (9.8 %) patients. At the same time, in 420 (6.4 %) cases, various options for repeated surgical interventions were used. Results. In 46 (23.4 %) cases, patients of the main group underwent laparoscopic cholecystectomy with endoscopic papillosphincterotomy (n = 10). In 5 (2.5 %) cases, percutaneous transhepatic cholangiography was performed to stop obstructive jaundice. Traditional surgical interventions with the formation of various variants of biliodegistic anastomoses were performed in 103 (52.5 %) patients. Postoperative complications in the main group were 23.0 %, and mortality was 9.6 %, while in the control group of patients, these figures were 36.0% and 19.3%, respectively. Conclusion. In the treatment of early postoperative intra-abdominal complications after surgical interventions on the liver and biliary tract, minimally invasive technology per indication is certainly considered the method of choice.
Features of hormonal function of the placenta in women with insulin resistance
Authors: Oripova Sh. N. 
Published: July 2022

Aim. To study the features of the hormonal function of the placenta in women with insulin resistance. Material and methods. To study the hormonal function of the placenta of women with insulin resistance, 86 pregnant women in the third trimester of pregnancy were tested for the insulin resistance index (HOMA index), and the level of hormones in the blood. Group I of women (main) consisted of 30 pregnant women with risk factors for diabetes mellitus with an IRI above 2,84. Group II included 26 women of the same group, but with an IRI below 2,84. Group III (control) – 30 healthy women. Results and discussion. With insulin resistance, the average level of hormones such as progesterone, placental lactogen, estradiol decreases, which indicates an unfavorable course of pregnancy and perinatal outcomes as a result of such a complication as placental insufficiency. Conclusion. The study of the features of the development of placental insufficiency under the influence of various risk factors will allow for timely prevention and treatment of this pathology, which will improve perinatal outcomes in women with insulin resistance. IR contributes to the metabolic needs of the fetus and is the result of circulating placental hormones.
Evaluation of some of chemical and physical properties and some nutrients in the soils and water of Bahr al-Najaf Depression-Iraq
Authors: Mutlag Nihad Habeeb , Hatimi Ibtihal. A. R Al 
Published: July 2022

This study was conducted in the laboratories of the Department of Environmental Sciences - College of Science - University of Kufa, with the aim of measuring the chemical and physical properties of soil and water in the Bahr Al-Najaf depression. Samples were collected in October 2021 from three different sites with three replicates for each site. The results showed that the water in all sites were alkaline, with the highest value for site 2 of third replicate which pH reach 10.5, while the lowest value was for site 1 ,pH was 9.6.The electrical conductivity was the highest in the first and third site that reach 9.76 ms/cm,while the lower in site 2 which was 8.68 ms/cm. .The temperature was within the average (28_25) Celsius. The results also showed an increasing in salinity in sites 1 and 3 by 7.3 mg / l, and decreasing in the concentration of salts that was observed at site 2 of 5.5 mg / l. This study found a decrease in the nutrient concentrations in the water samples of Bahr Al-Najaf, where the highest concentration of NO3 was 0.86 US/l, and the highest concentration of PO4 was 0.248 mg/l.
CVS-Aetna Merger: Benefiting Consumers’ Health, If Not Their Pocketbooks
Authors: Gallori Catherine 
Published: July 2022

In October 2018, the Justice Department gave preliminary approval for the merger of CVS Heath, a multi-billion dollar pharmacy company, and Aetna, one of the nation’s largest health insurers, two giants in a field that is rapidly consolidating.1 Both companies maintain that the merger will reduce costs and inefficiencies, but outside groups have concerns about its anticompetitive nature: the Justice Department went so far as to require that Aetna divest all of its Medicare Part D (prescription drug) plans before it would approve the merger.[1] What does this mean for us, as health care consumers? The merger does align the objectives of CVS Health and Aetna with increasing patient health, most notably in creating incentives to reach Aetna customers before their health necessitates a visit to the hospital or another high cost site of care. However, the increased concentration in the pharmacy benefit management (PBM) industry and the anticompetitive effects of vertical integration in the health care industry could wipe out any cost savings for Aetna customers, and could even increase health care spending for consumers as a whole. So, even though the merger could actually benefit Aetna customers’ health, our pocketbooks might not appreciate it.
Food Stamp Policy is Failing. Here’s Why.
Authors: Plevyak Sajen 
Published: July 2022

Nearly 12% of Americans struggle to put food on the table.1 The Supplemental Nutrition Assistance Program (SNAP), formerly referred to as food stamps, has played a significant role in reducing hunger and the effects of inequality in America. In 2017, SNAP provided aid to 42 million Americans, with ⅔ of the beneficiaries being elderly, caring for children, or being disabled.2,3,4 The program has been threatened by Republican members of Congress whose plan would put millions of Americans in a state of food scarcity by mandating stricter work hour requirements . This initiative is misguided since an expansion of the program, rather than a reduction, is needed to improve the nation’s health, economy and efficiency of tax-payer spending . This article will dive deeper into the comparison between current policy and the ideal expansion, explaining how the latter is necessary for many in the working class to survive.
Pembuatan Jamu Herbal Serbuk Jahe Sebagai Obat Alternatif Diabetes Mellitus Pada Masyarakat Di Desa Lakomea
Authors: Mauliyana Andin , Mulyani Sri , Sailendra La Ode , Adamsyah Muhammad Ikhsan , Kurniawati Rezki , Jabar Firasnita , Ramadhan Arif Lam 
Published: July 2022

Diabetes Melitus adalah kondisi kronis yang terjadi ketika kadar glukosa darah meningkat karena tubuh tidak dapat menghasilkan dengan cukup atau karena tidak ada insulin atau insulin yang dihasilkan tidak dapat berfungsi dengan baik. WHO (2020) melaporkan bahwa Diabetes pada usia dewasa muda merupakan penyebab utama ke-7 DALY di Indonesia, terhitung 632,2 per 100.000 penduduk. Dibandingkan dengan orang tanpa diabetes, pasien dengan diabetes tipe 2 berusia 20-40 tahun memiliki harapan hidup 14 tahun lebih rendah pada pria dan 16 tahun lebih rendah pada wanita. Provinsi Sulawesi Tenggara didapatkan 2.436 kasus berdasarkan profil dinas kesehatan Sulawesi tenggara adalah banyak . Data penyakit DM yang dirawat di RSUD Kota Kendari mengalami fluktuasi. Penyakit DM tahun 2017 sebanyak 223 pasien, tahun 2018 sebanyak 190 pasien. Desa Lakomea memiliki jumlah penduduk 520 jiwa tahun 2021. Dengan jumlah Kepala Keluarga yakni berjumlah 150 KK Yang Terbagi Atas 3 Dusun. Puskesmas Anggalomoare merupakan salah satu Puskesmas di Kabupaten Konawe. Data Puskesmas Anggalomoare, penyakit Diabetes Melitus masuk kedalam Sepuluh besar penyakit Utama Yang banyak Diderita Oleh Masyarakat Desa Lakomea. Berdasarkan data diatas maka pengusul melakukan pengabdian kepada masyarakat tentang penyakit Diabetes Melitus di Desa Lakomea Kecamatan Anggalomoare Kabupaten Konawe. Untuk mencegah terjadinya komplikasi pada penderita diabetes di perlukan peran perawat. Adapun peran perawat yang dilakukan antara lain pada upaya promotif dan preventif yang sangat efektif untuk mencegah terjadinya Diabetes salah satunya dengan tindakan penyuluhan, yang bertujuan untuk mengetahui serta memahami resiko dari penyakit diabetes. Selain itu juga agar penderita diabetes mendapatkan edukasi tentang nutrisi yang baik, cara minum obat atau suntik insulin, menerapkan ilmu yang diberikan dalam kehidupan sehari-hari, mengetahui kadar gula darahnya dengan perilaku cek kesehatan secara berkala, serta mendapatkan konsultasi kesehatan dari tenaga medis