bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between colors, color preferences, and emotions among Japanese students: From elementary school to university
Authors: Baniani Mahshid 
Published: January 2022

AbstractThe purpose of this study is to identify whether young children can associate colors with emotion, and if there are any changes across development. For this purpose, a study consisting of three tasks (questionnaire regarding color preferences, color‐emotion matching task, and color assessment task) was designed, and was conducted among four age groups of elementary school aged 7–12 (M = 8.11), junior high school aged 13–15 (M = 14.1), high school aged 16–18 (M = 17.1), and university students aged 19–23 (M = 20.1). In total, 172 subjects participated in this study. Red and blue hues were most favorite colors across all age groups. However, gold was the most favorite color among elementary school students (p < 0.05). White was the most popular color for the bedroom (p < 0.01), followed by light blue. In the color‐emotion matching task, elementary school students associated all the negative emotions with black (p < 0.01). In addition, elementary school students used a greater number of color varieties for the emotions compared to other participants, and the number of color varieties decreased as the subjects grow older. From the color assessment task, it was observed that elementary school students are the only participants who assessed all the colors with all the feelings of very unhappy/unhappy, neutral, and happy/very happy (p < 0.05). The results further suggested that junior high, high school, and university students seem to agree more on color assessments and the results are quite similar across these age groups. In sum, it was concluded that children do associate colors with emotion. Moreover, the changes across development were observed in all the three tasks.
Cryosectioning
Authors: Ross Mark A. , Kohut Lauryn , Loughran Patricia A. 
Published: January 2022

AbstractThe protocols presented here describe steps for cryosectioning tissue samples to be used in light microscopy methodologies including histochemistry, enzyme immunohistochemistry, and immunofluorescence. © 2022 Wiley Periodicals LLC.Basic Protocol 1: Cryosectioning
Identification of rare cell populations in autofluorescence lifetime image data
Authors: Cardona Elizabeth N. , Walsh Alex J. 
Published: January 2022

AbstractDrug‐resistant cells and anti‐inflammatory immune cells within tumor masses contribute to tumor aggression, invasion, and worse patient outcomes. These cells can be a small proportion (<10%) of the total cell population of the tumor. Due to their small quantity, the identification of rare cells is challenging with traditional assays. Single cell analysis of autofluorescence images provides a live‐cell assay to quantify cellular heterogeneity. Fluorescence intensities and lifetimes of the metabolic coenzymes reduced nicotinamide adenine dinucleotide and oxidized flavin adenine dinucleotide allow quantification of cellular metabolism and provide features for classification of cells with different metabolic phenotypes. In this study, Gaussian distribution modeling and machine learning classification algorithms are used for the identification of rare cells within simulated autofluorescence lifetime image data of a large tumor comprised of tumor cells and T cells. A Random Forest machine learning algorithm achieved an overall accuracy of 95% for the identification of cell type from the simulated optical metabolic imaging data of a heterogeneous tumor of 20,000 cells consisting of 70% drug responsive breast cancer cells, 5% drug resistant breast cancer cells, 20% quiescent T cells and 5% activated T cells. High resolution imaging methods combined with single‐cell quantitative analyses allows identification and quantification of rare populations of cells within heterogeneous cultures
An energy efficient resource allocation and transmit antenna selection scheme in mm‐wave using massive multiple‐input multiple‐output technology
Authors: Singh Charanjeet , Kishoreraja Parasuram Chandrasekaran 
Published: January 2022

SummaryThe massive multiple‐input multiple‐output (MIMO) improves the reliability of transmission and capacity of the channel. Resource allocation (RA) and transmit antenna selection (TAS) can minimize the complexity in implementation and hardware costs. In this research, both the RA and the TAS of wireless communication in millimeter‐wave (mm‐wave) with massive MIMO technology are considered. Two different solutions are developed for this research such as the deep learning method for efficient resource allocation process and optimization algorithm for TAS process. Here, the RA process is done with the help of attention‐based capsule auto‐encoder (ACAE) architecture which allocates the radio resources like power, space, time and frequency to all the available users in the system. Further, battle royale optimization (BRO) algorithm is utilized to select an efficient antenna from multiple antennas at BS. This optimization algorithm optimally selects an efficient antenna so that, user equipment (UEs) can create high quality links and achieves a reduced power consumption rate of the whole architecture. The overall system performance depends on the selection of optimal antenna which in terms enhances spectral efficiency (SE), energy efficiency (EE), reliability, and diversity gain of MIMO technology. In this way, both RA and optimal antenna selection schemes are performed to maximize the overall performance of wireless communication with massive MIMO technology for 5G wireless communication applications. The implementation of the proposed methodology is evaluated on MATLAB. Finally, the efficiency of the developed method is improved with respect to the capacity, EE, and SE.
Adaptive equivalent consumption minimization strategy for hybrid electric ship
Authors: Gao Diju , Jiang Haoyang , Shi Weifeng , Wang Tianzhen , Wang Yide 
Published: January 2022

AbstractIn recent years, with the development of battery technology, hybrid electric ship (HES), as a promising solution to reduce the fuel consumption and emissions, has become a research hotspot. However, frequent use of the battery will accelerate the aging of the battery, and the replacement of scrapped battery will increase the cost of the ship. Therefore, it is necessary to consider delaying battery aging into the energy control strategy of HES. The equivalent consumption minimization strategy (ECMS) is a feasible energy control strategy because it can be implemented in real time. However, under the condition of uncertain initial state of charge (SOC) of the battery, ECMS cannot effectively reduce the fuel consumption unless the equivalent factor (EF) is optimized in real time. In this paper, an adaptive equivalent consumption minimization strategy (A‐ECMS) is proposed, which extracts the global optimal EF trajectory from the dynamic programming (DP) solution and uses the back propagation (BP) neural network to adjust the EF in real time. A trade‐off between the fuel consumption and battery aging is made in the cost function by introducing a weight coefficient. Finally, the effectiveness and the adaptability of the proposed strategy are verified in MATLAB.
Selection of superior genotypes of Indian jujube (Ziziphus mauritiana Lamk.) as revealed by fruit‐related traits
Authors: Mirheidari Farhad , Khadivi Ali , Saeidifar Abdolvahid , Moradi Younes 
Published: January 2022

AbstractThe nutritional and medicinal benefits of Ziziphus mauritiana Lamk. have led to its attention. Here, morphological and pomological diversity of this species was investigated. Most of the characters recorded showed considerable differences among the genotypes studied. The range of ripening data was from mid‐February to mid‐March. Fruit weight ranged between 15.68 and 33.62 g with an average of 24.17. Strong diversity was observed among the genotypes in terms of fruit skin ground color, ranging from light green to orange. There were significant correlations between some characters especially between the traits related to fruit size. Principal component analysis (PCA) classified the traits into 12 main components, justifying 75.07% of the total variance. The studied genotypes were grouped into two main clusters, indicating strong diversity among them. The present information might be used to choose the genotypes with the desired traits. Twenty‐one genotypes were promising because of high values of fruit weight, fruit taste, fruit skin color, and fruit quality, and thus, they can be recommended for direct cultivation and also to be used in breeding programs. The genotypes with superior traits can be further used for improvement through selection and hybridization to get desired traits.
Ceramic‐based dielectric metamaterials
Authors: Luo Weijia , Yan Sen , Zhou Ji 
Published: January 2022

AbstractDielectric metamaterials based on ceramics have attracted considerable interest in the past few years owing to their low dielectric loss, simple structure, excellent multifield tunability, and good environmental adaptability. They are considered to be promising alternative to metal‐based metamaterials and can lead to a new strategy for the development of passive devices. In this review, the recent progress of ceramic‐based dielectric metamaterials in electromagnetic applications, energy applications, non‐Hermitian systems, and natural materials with near‐zero or negative refraction are summarized. The design principle and mechanism, as well as manufacturing technologies, are also introduced, and the current development trend of ceramic‐based dielectric metamaterials are proposed.
Quantifying the absolute number of cancer deaths that would be avoided if cancers were diagnosed prior to progressing to distant metastasis, New South Wales, Australia 1985‐2014
Authors: Yu Xue Qin , Dasgupta Paramita , Baade Peter 
Published: January 2022

AbstractOur study measures the impact of diagnosing cancers early before they metastasise on reducing the burden of cancer death. A cohort of 716 501 people aged 15 to 89 years diagnosed with a solid cancer in New South Wales, Australia, during 1985 to 2014 were followed‐up to December 2015. Crude probabilities of cancer death by stage at diagnosis were calculated for all solid cancers combined and five individual cancers using flexible parametric relative survival models. These probabilities were used to estimate the number of avoided cancer deaths within 10 years of diagnosis in three 10‐year diagnostic periods if all cases with known distant stage were instead diagnosed at an earlier stage. Cancers are known to be diagnosed at distant stage composed ~16% of all solid cancers diagnosed during 2005 to 2014. Assuming all these cases were instead diagnosed at regional stage, an annual average of 2064 cancer deaths would have been potentially avoided within 10 years of diagnosis. This equated to ~21% of modelled observed deaths. Alternatively, if half of all known distant cases diagnosed during 2005 to 2014 were diagnosed as regional and half as localised, the average number of deaths avoided per year would increase to 2677 (~28%). Estimates varied by diagnostic period, sex and cancer type, reflecting both the different stage distributions for the cancer types, and the respective survival differences between cancer stages. While prevention is the most effective pillar of cancer control, these findings quantify the potential benefits of diagnosing all cancer types when they are less advanced to reduce the burden of cancer mortality.
Risk of malignancy in patients with inflammatory bowel disease: A population‐based cohort study from China
Authors: Zhang Huimin , Zhang Mengmeng , Chen Xuanfu , Guo Mingyue , Zhou Runing , Lv Hong , Li Yue , Tan Bei , Li Ji , Xu Hui , Zheng Weiyang , Yang Hong , Qian Jiaming 
Published: January 2022

AbstractCarcinogenesis is one of the major complications for patients with inflammatory bowel disease (IBD) and causes poor prognosis. We aimed to describe cancer incidence in the Chinese IBD cohort compared to general population‐based cancer registration data and further explore associated risk factors for cancer occurrence in IBD patients. IBD inpatients from January 1998 to January 2018 in Peking Union Medical College Hospital (PUMCH) were included in our study. Patients were followed‐up from the date of IBD diagnosis until either the date of first cancer diagnosis or January 2019. Standardized incidence ratios (SIRs) of overall cancer and site‐specific cancers were calculated. A total of 869 Ulcerative Colitis (UC) and 516 Crohn's disease (CD) patients were finally included with median follow‐up time of 7 and 5 years, respectively. Fifty‐three cases developed malignancies. After standardization by age and gender, SIR of total cancer occurrence in IBD patients was 1.77 (95% CI, 1.33‐2.32). As for UC, digestive cancers (SIR 3.75; 95% CI, 2.29‐5.80), thyroid cancer (SIR 10.34; 95% CI, 4.72‐19.64) and hematological malignancies (SIR 6.25; 95% CI, 1.68‐16.00) had the highest incidence, which were prominent in young and middle‐aged patients. Use of steroids, immunosuppressants or infliximab did not present higher risk of malignancies in UC patients. There was no significant difference in cancer risk between CD patients and general population. In conclusion, the increased risks of multiple cancers are particularly prominent in Chinese UC patients and these findings can provide more targeted guidance for cancer monitoring in Chinese IBD patients.
Ciliary IFT88 Protects Coordinated Adolescent Growth Plate Ossification From Disruptive Physiological Mechanical Forces
Authors: Coveney Clarissa R , Samvelyan Hasmik J , Miotla-Zarebska Jadwiga , Carnegie Josephine , Chang Emer , Corrin C Jonty , Coveney Trystan , Stott Bryony , Parisi Ida , Duarte Claudia , Vincent Tonia L , Staines Katherine A , Wann Angus KT 
Published: January 2022

ABSTRACT
Compared with our understanding of endochondral ossification, much less is known about the coordinated arrest of growth defined by the narrowing and fusion of the cartilaginous growth plate. Throughout the musculoskeletal system, appropriate cell and tissue responses to mechanical force delineate morphogenesis and ensure lifelong health. It remains unclear how mechanical cues are integrated into many biological programs, including those coordinating the ossification of the adolescent growth plate at the cessation of growth. Primary cilia are microtubule-based organelles tuning a range of cell activities, including signaling cascades activated or modulated by extracellular biophysical cues. Cilia have been proposed to directly facilitate cell mechanotransduction. To explore the influence of primary cilia in the mouse adolescent limb, we conditionally targeted the ciliary gene Intraflagellar transport protein 88 (Ift88fl/fl) in the juvenile and adolescent skeleton using a cartilage-specific, inducible Cre (AggrecanCreERT2 Ift88fl/fl). Deletion of IFT88 in cartilage, which reduced ciliation in the growth plate, disrupted chondrocyte differentiation, cartilage resorption, and mineralization. These effects were largely restricted to peripheral tibial regions beneath the load-bearing compartments of the knee. These regions were typified by an enlarged population of hypertrophic chondrocytes. Although normal patterns of hedgehog signaling were maintained, targeting IFT88 inhibited hypertrophic chondrocyte VEGF expression and downstream vascular recruitment, osteoclastic activity, and the replacement of cartilage with bone. In control mice, increases to physiological loading also impair ossification in the peripheral growth plate, mimicking the effects of IFT88 deletion. Limb immobilization inhibited changes to VEGF expression and epiphyseal morphology in Ift88cKO mice, indicating the effects of depletion of IFT88 in the adolescent growth plate are mechano-dependent. We propose that during this pivotal phase in adolescent skeletal maturation, ciliary IFT88 protects uniform, coordinated ossification of the growth plate from an otherwise disruptive heterogeneity of physiological mechanical forces. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Saturated and Unsaturated Bone Marrow Lipids Have Distinct Effects on Bone Density and Fracture Risk in Older Adults
Authors: Woods Gina N. , Ewing Susan K. , Schafer Anne L. , Gudnason Vilmundur , Sigurdsson Sigurdur , Lang Thomas , Hue Trisha F. , Kado Deborah M. , Vittinghoff Eric , Rosen Clifford , Li Xiaojuan , Schwartz Ann V. 
Published: January 2022

ABSTRACT
Greater bone marrow adiposity (BMAT) is associated with lower bone mineral density (BMD) and vertebral fractures; less is known about BMAT composition and bone. We studied BMAT composition and bone outcomes in 465 participants from the Age Gene/Environment Susceptibility (AGES)-Reykjavik study. BMAT saturation and unsaturation, measured with magnetic resonance spectroscopy, were defined as the ratio of saturated (1.3 ppm peak) or unsaturated (5.3 ppm peak) lipid to total marrow contents, respectively. At baseline and follow-up visits, spine and hip BMD were assessed with quantitative computed tomography (QCT) and dual-energy X-ray absorptiometry (DXA) and vertebral fractures were identified with DXA. Incident clinical fractures were identified through medical records for up to 8.8 years of follow-up. Associations between BMAT composition and BMD, bone loss, and fractures were evaluated in adjusted regression models. At baseline, mean ± standard deviation (SD) participant age was 81.7 ± 4.3 years, mean BMAT unsaturation was 3.5% ± 1.0%, and mean saturation was 46.3% ± 7.2% in the full cohort (47.7% women). Each SD increase in BMAT saturation was associated with lower trabecular BMD: −23.6% (spine) and −13.0% (total hip) (all p &lt; 0.0001). Conversely, BMAT unsaturation (per SD increase) was associated with higher trabecular BMD: +17.5% (spine) and +11.5% (total hip) (all p &lt; 0.001). BMAT saturation (per SD increase) was associated with greater risk for prevalent (odds ratio [OR] 1.46; 95% confidence interval [CI], 1.11–1.92) and incident (OR 1.55; 95% CI, 1.03–2.34) vertebral fracture. BMAT unsaturation (per SD increase) was associated with lower risk for incident vertebral fracture (OR 0.58; 95% CI, 0.38–0.89). In gender stratified analyses, BMAT saturation and unsaturation had opposite associations with incident clinical fracture among men. In general, saturated marrow lipids were associated with worse skeletal outcomes, whereas unsaturated lipids were associated with better outcomes. We recommend that future studies of marrow fat and skeletal health report measurements of saturated and unsaturated marrow lipids, rather than total marrow fat content alone. © 2022 American Society for Bone and Mineral Research (ASBMR).
Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID‐19 patients
Authors: Jha Prakash , Singh Prithvi , Arora Shweta , Sultan Armiya , Nayek Arnab , Ponnusamy Kalaiarasan , Syed Mansoor Ali , Dohare Ravins , Chopra Madhu 
Published: January 2022

AbstractCOVID‐19 is a sneaking deadly disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The rapid increase in the number of infected patients worldwide enhances the exigency for medicines. However, precise therapeutic drugs are not available for COVID‐19; thus, exhaustive research is critically required to unscramble the pathogenic tools and probable therapeutic targets for the development of effective therapy. This study utilizes a chemogenomics strategy, including computational tools for the identification of viral‐associated differentially expressed genes (DEGs), and molecular docking of potential chemical compounds available in antiviral, anticancer, and natural product‐based libraries against these DEGs. We scrutinized the messenger RNA expression profile of SARS‐CoV‐2 patients, publicly available on the National Center for Biotechnology Information–Gene Expression Omnibus database, stratified them into different groups based on the severity of infection, superseded by identification of overlapping mild and severe infectious (MSI)‐DEGs. The profoundly expressed MSI‐DEGs were then subjected to trait‐linked weighted co‐expression network construction and hub module detection. The hub module MSI‐DEGs were then exposed to enrichment (gene ontology + pathway) and protein–protein interaction network analyses where Rho guanine nucleotide exchange factor 1 (ARHGEF1) gene conjectured in all groups and could be a probable target of therapy. Finally, we used the molecular docking and molecular dynamics method to identify inherent hits against the ARHGEF1 gene from antiviral, anticancer, and natural product‐based libraries. Although the study has an identified significant association of the ARHGEF1 gene in COVID19; and probable compounds targeting it, using in silico methods, these targets need to be validated by both in vitro and in vivo methods to effectively determine their therapeutic efficacy against the devastating virus.
Career motivation and satisfaction of dental hygiene students in associate versus bachelor degree programs: A national survey
Authors: Rabeeah Zainulabdeen , Carreno Jocelid G. , Kinney Janet S. , Inglehart Marita R. 
Published: January 2022

AbstractObjectivesEntry‐level dental hygiene programs give associate (AD) and bachelor degrees (BD). The objectives were to compare how AD versus BD students differ in career‐related role models and information sources, career motivations, and satisfaction and to explore the relationships between career motivations and satisfaction.MethodsTwo hundred seventy‐one students in AD and 269 students in BD programs responded to a survey.ResultsAD students were older than BD students (26.71/23.6; p < 0.001). Both groups were most likely to name a nurse/dental hygienist (37.6%/37.3%) as role models in their families, were likely to have shadowed a dental hygienist (77.6%/75.0%), and had talked to a health professional (27.7%/23.7%) prior to program application. BD students decided earlier to become dental hygienists (17.20/19.97 years; p < 0.001) and were less likely to have been dental assistants before than AD students (28.3%/36.9%; p = 0.034). Both groups agreed strongly that they wanted to become dental hygienists to help patients (5‐point scale with 5 = agree strongly: 4.88/4.86), make a difference in the life of patients (4.88/4.86) and because it is a flexible career (4.83/4.80). Open‐ended responses showed that 62.4% of AD students compared to 35.3% of BD students choose their career because of lifestyle considerations (p < 0.001), while 47.2% of BD students versus 38.0% of AD students wanted to work in the healthcare field (p < 0.001). Both groups had high job satisfaction (3‐point scale: 2.94/2.97). For AD students, job satisfaction correlated with wanting to help patients (r = 0.49; p < 0.01) and with making a difference in the life of patients (r = 0.52; p < 0.001). For BD students, wanting to work in a team (r = 0.34; p < 0.001) and having a dentist in the family (r = 0.32; p < 0.001) correlated with job satisfaction.ConclusionsDental hygiene students in AD versus BD programs differ in the factors that are associated with job satisfaction. Dental hygiene educators can utilize these findings when recruiting future students. The findings related to motivational determinants of job satisfaction can guide educational efforts.