bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Does Aging Affect Social Attention? A Test of Competing Theories Using Multilevel Meta-Analysis
Authors: McKay Kate T , Talipski Louisa A , Grainger Sarah A , Alister Manikya , Henry Julie D 
Published: March 2022

Abstract

Objectives
The present study provides a meta-analytic assessment of how gaze-cued attention—a core social-cognitive process—is influenced by normal adult aging.

Methods
A multilevel meta-analysis of standardized mean changes was conducted on gaze-cueing effects. Age effects were quantified as standardized mean differences in gaze-cueing effect sizes between young and older adult samples.

Results
We identified 82 gaze-cueing effects (k = 26, N = 919 participants). Of these, 37 were associated with young adults (k = 12, n = 438) and 45 with older adults (k = 14, n = 481). Relative to younger adults, older adults had a reduced gaze-cueing effect overall, g = −0.59, with this age effect greater when the cues were predictive, g = −3.24, rather than nonpredictive, g = −0.78.

Discussion
These results provide the clearest evidence to date that adult aging is associated with a reduction in gaze-cued attention. The results also speak to potential mechanisms of this age effect. In line with cognitive decline models of aging, it was demonstrated that when gaze cues were predictive, only younger adults seem to benefit, suggesting that older adults exhibit a particularly reduced capacity to use gaze cues volitionally.
MiR-29a regulates cardiomyocyte apoptosis by targeting Bak1 in diabetic cardiomyopathy
Authors: Wang Xiaoyan , Zhang Zhitao , Wang Mei 
Published: March 2022

Abstract
This study sought to investigate the association between microRNA-29a (miR-29a) and cardiomyocyte apoptosis in diabetic cardiomyopathy (DCM). DCM rat model was established by treating rats with streptozotocin (STZ), followed by injection of NC or miR-29a-3p mimics into the myocardium of rats. High glucose (HG)-treated H9c2 cells were transfected with NC and miR-29a-3p mimics. DCM rats presented elevated levels of blood glucose, HbA1c, blood pressure, urine output, decreased body weight and cardiac contractile function after modeling. MiR-29a was lowly expressed in STZ-treated rats and HG-treated H9c2 cells. Upregulation of miR-29a improved cardiac structure and function and attenuated, alleviated myocardial histological abnormalities and fibrosis and lowered cardiomyocyte apoptosis in DCM rats. Meanwhile, HG promoted H9c2 cell apoptosis, while miR-29a overexpression attenuated the function of HG. Compared with control group, the protein expression of Bax, cleaved-caspase3 and Bak1 in DCM and HG groups were significantly upregulated, and the expression of Bcl-2 and Mcl-1 was downregulated, while miR-29a overexpression exerted opposite effect. Bioinformatics prediction method and western blot revealed that miR-29a directly targeted Bak1 and downregulated Bak1 expression. Overall, miR-29a regulated STZ- and HG-induced cardiomyocyte apoptosis by targeting Bak1, providing a novel understanding of the pathogenesis of DCM.
Trapping of Crucifer-Feeding Flea Beetles (Phyllotreta spp.) (Coleoptera: Chrysomelidae) With Pheromones and Plant Kairomones
Authors: Weber Donald C , Konstantinov Alexander S , Khrimian Ashot , Bier Alexander D , Lubenow Lesley A , Knodel Janet J , Haber Ariela I , Wallingford Anna K , Mason James A C , Kuhar Thomas P 
Published: March 2022

Abstract
Flea beetles (Coleoptera: Chrysomelidae) of the genus Phyllotreta are major pests of cole crops, canola, and related crops in the mustard family (Brassicaceae). Adults may damage seedlings or larger crop plants, impairing crop growth, rendering crops unmarketable, or killing seedlings outright. The two major North American crucifer pest species, Phyllotreta striolata (F.) and Phyllotreta cruciferae (Goeze), have male-produced pheromones attractive to both female and male adults. We tested the racemic synthetic pheromones, himachaladiene and hydroxyhimachalanone, as well as the host-plant-produced allyl isothiocyanate, alone and in combination, with experimental trapping in Maryland, Virginia, and North Dakota, using clear and yellow sticky traps and the ground-based ‘rocket’ trap (modified from boll weevil trap). Phyllotreta striolata was consistently attracted to the hydroxyketone, and captures were often enhanced by allyl isothiocyanate (AITC), but its response to pheromones, AITC, and trap color were variable from state to state. Phyllotreta cruciferae was strongly attracted to AITC, but its response to pheromone components varied by state, and this species was found rarely at the Maryland site. Phyllotreta bipustulata (F.) was attracted to the diene component, a new finding for this species. Several other genera of flea beetles were captured, some showing response to the semiochemicals and/or color. Results will be helpful in monitoring and possibly population suppression; however, further research is necessary to develop more efficient syntheses, optimal lure loadings, combinations, and controlled release methods.
Arthroscopic hip surgery offers better early patient-reported outcome measures than targeted physiotherapy programs for the treatment of femoroacetabular impingement syndrome: a systematic review and meta-analysis of randomized controlled trials
Authors: Mahmoud Samer S S , Takla Amir , Meyer Denny , Griffin Damian , O’Donnell John 
Published: March 2022

ABSTRACT
Targeted physiotherapy programs (TPP), and surgery, using either open surgical hip dislocation or hip arthroscopy (HA), are the treatment modalities available for femoroacetabular impingement syndrome (FAIS). Randomized controlled trials have recently been performed to compare these treatment options. This review was performed to provide a focused synthesis of the available evidence regarding the relative value of treatment options. A systematic search was performed of Medline, Embase, Cochrane Library and ClinicalTrials.gov databases. Inclusion criteria were randomized controlled trials comparing treatment methods. The Cochrane Risk of Bias assessment tool (RoB2) was used to assess the selected studies. A meta-analysis was performed between homogenous studies. Four trials were identified including 749 patients (392 males). The mean ages of the cohorts ranged between 30.1 and 36.2 years old. Three hundred thirty-five patients underwent HA by 46 surgeons among all trials. Fifty-two patients crossed over from the TPP to the HA group. One of the trials was found to have a high risk of bias, while the other three were between low risk and some concerns. The iHOT-33 was the most commonly used patient-reported outcome measure followed by the HOS ADL and EQ-5D-5L. Others scores were also identified. Scores from two trials could be pooled together for meta-analysis. Apart from SF-12 and GRC, all other scores have shown significantly better outcomes with HA in comparison to TPP at 8- and 12-months follow-up points. HA offers better patient-reported outcomes than TPP for management of FAIS at 8- and 12-months follow-up.
Rare case of ruptured muscular ventricular septal aneurysm due to silent myocardial ischemia in adult
Authors: Kawahira Toshihiro , Miyashita Fumihiro , Suzuki Tomoaki 
Published: March 2022

AbstractInterventricular septal aneurysm of muscular type is uncommon in adult, to say nothing of membranous type. Acute or subacute left-to-right shunt (LR shunt) in a ventricular septum is mostly critical and usually shows severe symptoms. Therefore, ruptured muscular ventricular septal aneurysm (VSA) with LR shunt of unknown onset in adult is highly rare. A 70-year-old man was suffered from mild dyspnea and chest oppression. A muscular VSA was detected at the center of the ventricular septum and LR shunt of unknown onset in it had induced congestive heart failure. The sandwich patch technique through a right ventricular approach was simultaneously performed with coronary artery bypass grafting and the postoperative course was uneventful. In addition, concomitant myocardial biopsy of VSA wall during the surgery could reveal histopathologic evidence of acute or subacute myocardial infarction with old myocardial infarction as silent myocardial ischemia.
The Charlemont Library, the Sotheby Warehouse Fire of 1865, and the Vexed Provenance of British Library MS Egerton 1994
Authors: Freeman Arthur , Freeman Janet Ing 
Published: March 2022

Abstract
This article discusses the book collection of James Caulfeild (1728–1799), first earl of Charlemont in the Irish peerage, with particular reference to his holdings of early English drama and poetry. After the death of Charlemont’s son the library was consigned to Sotheby’s for anonymous sale in July 1865, but was in large part destroyed in the Sotheby warehouse fire of 19 June. The second part of the article explores the provenance of one surviving item, a volume of fifteen manuscript plays composed over four or five decades before 1644, now British Library, MS Egerton 1994. It is among the most interesting survivals known from the slender corpus of pre-Restoration English stage documents. Charlemont’s principal London agent for early English books, the Shakespeare editor Edmond Malone (1741–1812), has long been viewed as the source of the volume. The history of this speculation is traced and disproved.
Guest Editors’ Introduction—Visionary Praxis: Paule Marshall’s, Ntozake Shange’s, and Toni Morrison’s Foresight concerning Sick Violence and Violent Sickness
Authors: Brooks Robin , Yates-Richard Meina 
Published: March 2022

Abstract
This introduction provides an overview of the special issue that focuses on the interconnections of Black women’s literary studies with the crises of COVID-19 and ongoing anti-Black violence. More specifically, it considers how the work of three renowned writers, Paule Marshall, Ntozake Shange, and Toni Morrison—which collectively spans over fifty years—offers models for how to reimagine our current circumstances and create more just futures in our national and global communities. The essay identifies and expounds on the overarching question of the special issue: how does the work of Marshall, Shange, and Morrison speak to contemporary affairs and concerns? By engaging this question, this collection of essays offers new insights about these women’s writing in particular and expands the corpus of scholarship on Black women’s writing in general. In the aftermath of the passing of these writers, a collective reappraisal of their oeuvres is a timely and fitting tribute, as each of their bodies of work reveals that they long have engaged concerns about Black people’s encounters with systemic barriers that have laid the foundation for the current twinned crises of anti-Black violence and the disproportionate impact of COVID-19.
The mitogenome of the sunken wood limpetNotocrater youngi: insights into mitogenome evolution in Lepetellida (Gastropoda: Vetigastropoda)
Authors: Uribe Juan E , Sei Makiri , Harasewych M G 
Published: March 2022

ABSTRACTThe complete mitochondrial genome of the pseudococculinid limpet Notocrater youngi was determined using Illumina sequencing and found to be a double-stranded circular molecule 15,915 bp in length. It contains the usual 13 protein-coding genes, 2 ribosomal RNA genes and 22 transfer RNA genes, although with a gene order that differs from those of all other presently known Vetigastropoda, and that is derived within Lepetellida. Phylogenetic analyses based on amino acid sequences join the three pseudococculinid species in a clade and confirm the well-supported clade Scissurelloidea + (Lepetelloidea + Lepetodriloidea) but not a monophyletic Lepetellida as currently understood. Patterns of gene order rearrangements are concordant with these findings.
Apparently Imperfect: On the Analytical Issues of the IAC
Authors: Zhang Xieyi (Abby) 
Published: March 2022

AbstractThis article examines the analytical nuances of the imperfect authentic cadence (IAC). Whereas the cadential hierarchy currently in use in most North American textbooks suggests in no uncertain terms that it is stronger than the half cadence (HC) and weaker than the perfect authentic cadence (PAC), its appearances in the musical literature have often been far more nuanced, as illustrated by the frequency with which the IAC functions in a manner that contradicts the standard theoretical formulation. The IAC’s ability to engage with these alternative functions results in a range of cadential strengths, giving rise to possibilities for ambiguities, reinterpretations, and conflicts that in turn may set the stage for fascinating expressive and narrative twists.
Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease
Authors: Jobbins Andrew M , Haberman Nejc , Artigas Natalia , Amourda Christopher , Paterson Helen A B , Yu Sijia , Blackford Samuel J I , Montoya Alex , Dore Marian , Wang Yi-Fang , Sardini Alessandro , Cebola Inês , Zuber Johannes , Rashid Sheikh Tamir , Lenhard Boris , Vernia Santiago 
Published: March 2022

Abstract
Pre-mRNA processing is an essential mechanism for the generation of mature mRNA and the regulation of gene expression in eukaryotic cells. While defects in pre-mRNA processing have been implicated in a number of diseases their involvement in metabolic pathologies is still unclear. Here, we show that both alternative splicing and alternative polyadenylation, two major steps in pre-mRNA processing, are significantly altered in non-alcoholic fatty liver disease (NAFLD). Moreover, we find that Serine and Arginine Rich Splicing Factor 10 (SRSF10) binding is enriched adjacent to consensus polyadenylation motifs and its expression is significantly decreased in NAFLD, suggesting a role mediating pre-mRNA dysregulation in this condition. Consistently, inactivation of SRSF10 in mouse and human hepatocytes in vitro, and in mouse liver in vivo, was found to dysregulate polyadenylation of key metabolic genes such as peroxisome proliferator-activated receptor alpha (PPARA) and exacerbate diet-induced metabolic dysfunction. Collectively our work implicates dysregulated pre-mRNA polyadenylation in obesity-induced liver disease and uncovers a novel role for SRSF10 in this process.
Molecular basis for human mitochondrial tRNA m3C modification by alternatively spliced METTL8
Authors: Huang Meng-Han , Peng Gui-Xin , Mao Xue-Ling , Wang Jin-Tao , Zhou Jing-Bo , Zhang Jian-Hui , Chen Meirong , Wang En-Duo , Zhou Xiao-Long 
Published: March 2022

Abstract
METTL8 has recently been identified as the methyltransferase catalyzing 3-methylcytidine biogenesis at position 32 (m3C32) of mitochondrial tRNAs. METTL8 also potentially participates in mRNA methylation and R-loop biogenesis. How METTL8 plays multiple roles in distinct cell compartments and catalyzes mitochondrial tRNA m3C formation remain unclear. Here, we discovered that alternative mRNA splicing generated several isoforms of METTL8. One isoform (METTL8-Iso1) was targeted to mitochondria via an N-terminal pre-sequence, while another one (METTL8-Iso4) mainly localized to the nucleolus. METTL8-Iso1-mediated m3C32 modification of human mitochondrial tRNAThr (hmtRNAThr) was not reliant on t6A modification at A37 (t6A37), while that of hmtRNASer(UCN) critically depended on i6A modification at A37 (i6A37). We clarified the hmtRNAThr substrate recognition mechanism, which was obviously different from that of hmtRNASer(UCN), in terms of requiring a G35 determinant. Moreover, SARS2 (mitochondrial seryl-tRNA synthetase) interacted with METTL8-Iso1 in an RNA-independent manner and modestly accelerated m3C modification activity. We further elucidated how nonsubstrate tRNAs in human mitochondria were efficiently discriminated by METTL8-Iso1. In summary, our results established the expression pattern of METTL8, clarified the molecular basis for m3C32 modification by METTL8-Iso1 and provided the rationale for the involvement of METTL8 in tRNA modification, mRNA methylation or R-loop biogenesis.
Human TDP1, APE1 and TREX1 repair 3′-DNA–peptide/protein cross-links arising from abasic sites in vitro
Authors: Wei Xiaoying , Wang Zhishuo , Hinson Caroline , Yang Kun 
Published: March 2022

Abstract
Histones and many other proteins react with abundant endogenous DNA lesions, apurinic/apyrimidinic (abasic, AP) sites and/or 3′-phospho-α,β-unsaturated aldehyde (3′-PUA), to form unstable but long-lived Schiff base DNA–protein cross-links at 3′-DNA termini (3′-PUA–protein DPCs). Poly (ADP-ribose) polymerase 1 (PARP1) cross-links to the AP site in a similar manner but the Schiff base is reduced by PARP1’s intrinsic redox capacity, yielding a stable 3′-PUA–PARP1 DPC. Eradicating these DPCs is critical for maintaining the genome integrity because 3′-hydroxyl is required for DNA synthesis and ligation. But how they are repaired is not well understood. Herein, we chemically synthesized 3′-PUA-aminooxylysine-peptide adducts that closely resemble the proteolytic 3′-PUA–protein DPCs, and found that they can be repaired by human tyrosyl-DNA phosphodiesterase 1 (TDP1), AP endonuclease 1 (APE1) and three-prime repair exonuclease 1 (TREX1). We characterized these novel repair pathways by measuring the kinetic constants and determining the effect of cross-linked peptide length, flanking DNA structure, and the opposite nucleobase. We further found that these nucleases can directly repair 3′-PUA–histone DPCs, but not 3′-PUA–PARP1 DPCs unless proteolysis occurs initially. Collectively, we demonstrated that in vitro 3′-PUA–protein DPCs can be repaired by TDP1, APE1, and TREX1 following proteolysis, but the proteolysis is not absolutely required for smaller DPCs.
Substantial transition to clean household energy mix in rural China
Authors: Shen Guofeng , Xiong Rui , Tian Yanlin , Luo Zhihan , Jiangtulu Bahabaike , Meng Wenjun , Du Wei , Meng Jing , Chen Yuanchen , Xue Bing , Wang Bin , Duan Yonghong , Duo Jia , Fan Fenggui , Huang Lei , Ju Tianzhen , Liu Fenggui , Li Shunxin , Liu Xianli , Li Yungui , Wang Mu , Nan Ying , Pan Bo , Pan Yanfang , Wang Lizhi , Zeng Eddy , Zhan Chao , Chen Yilin , Shen Huizhong , Cheng Hefa , Tao Shu 
Published: March 2022

Abstract
The household energy mix has significant impacts on human health and climate, as it contributes greatly to many health- and climate-relevant air pollutants. Compared to the well-established urban energy statistical system, the rural household energy statistical system is incomplete and is often associated with high biases. Via a nationwide investigation, this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector, while electricity comprised ∼20%. Stacking (the use of multiple sources of energy) is significant, and the average number of energy types was 2.8 per household. Compared to 2012, the consumption of biomass and coals in 2017 decreased by 45% and 12%, respectively, while the gas consumption amount increased by 204%. Increased gas and decreased coal consumptions were mainly in cooking, while decreased biomass was in both cooking (41%) and heating (59%). The time-sharing fraction of electricity and gases (E&G) for daily cooking grew, reaching 69% in 2017, but for space heating, traditional solid fuels were still dominant, with the national average shared fraction of E&G being only 20%. The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030, particularly in less-developed rural and mountainous areas. In some non-typical heating zones, the increased share of E&G for heating was significant and largely driven by income growth, but in typical heating zones, the time-sharing fraction was &lt;5% and was not significantly increased, except in areas with policy intervention. The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition. Higher income, higher education, younger age, less energy/stove stacking and smaller family size positively impacted the clean energy transition.
Does the evidence support a relationship between higher levels of nut consumption, lower risk of depression, and better mood state in the general population? A systematic review
Authors: Fernández-Rodríguez Rubén , Jiménez-López Estela , Garrido-Miguel Miriam , Martínez-Ortega Isabel A , Martínez-Vizcaíno Vicente , Mesas Arthur Eumann 
Published: March 2022

Abstract

Context
Dietary patterns play a key role in mental health, depression, and mood state. However, the evidence concerning specific foods highly recommended for mental health, such as nuts, has not yet been synthesized.

Objective
The objective of this review was to synthesize the evidence for a relationship between higher levels of nut consumption, lower risk of depression, and better mood state in the general population.

Data Sources
The MEDLINE, Scopus, Cochrane Central, Web of Science, and PsycInfo databases were systematically searched from each database’s inception to March 2021.

Data Extraction
Randomized clinical trials (RCTs) and observational studies exploring the association between nut consumption, level of depression, and mood state in the general population were included. The quality of the studies was measured through the Joanna Briggs Institute tool (cross-sectional studies), the NIH Quality Assessment Tool (cohort studies), and the Cochrane Risk-of-Bias tool (RCTs). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed.

Data Analysis
A total of 10 studies involving 66 418 individuals were included, of which 3 were cross-sectional, 3 were cohort studies, and 4 were RCTs. In studies concerned with depression (n = 6 studies), a higher level of nut consumption was associated with a lower risk of depression in 2 cross-sectional studies and 1 cohort study, while a similar but nonsignificant association was found in another cohort and in two RCTs. In studies concerned with mood state (n = 4), 1 cohort study reported an association between higher nut consumption and significant improvement in mood state, whereas (nonsignificant) associations between higher nut consumption and increased negative feelings were reported in a cross-sectional study and two RCTs.

Conclusion
Despite the small number of studies and the limitations related to them, such as reverse causation bias, overall, the available literature suggests that higher nut consumption could be associated with a lower risk of depression, fewer depressive symptoms, and better mood state in the general population.

Systematic Review Registration
PROSPERO registration no. CRD42021241070.