bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of post-treatment on local mechanical properties of additively manufactured impellers made of maraging steel
Authors: Raghavan Srinivasan , Dzugan Jan , Rzepa Sylwia , Podany Pavel , Soh Norman , Hao Lim Jia , Khan Niaz 
Published: September 2022

Purpose
This study aims to investigate the effect of the wall thickness, deposition orientation and two different post-processing methods on the local mechanical properties and microstructure of additively manufactured parts made of maraging steel. In order to examine the local properties of the build, miniaturized testing specimens were employed. Before application of small-sized specimens, their performance was verified.

Design/methodology/approach
The investigation was composed of two stages. As first, the part thickness, specimen size and orientation were studied on a laser-powder bed fusion (L-PBF) platform with deposited walls of various thicknesses made of maraging steel. Subsequently, the influence of different heat-treatment methods was investigated on the final product, i.e. impellers. The miniaturized and standard tensile tests were performed to investigate the local mechanical properties. The porosity, microstructures and fracture surfaces were analysed by X-ray-computed tomography, X-ray diffraction and scanning electron microscopy with electron backscatter diffraction.

Findings
The results revealed good agreement between the values provided by miniaturized and standard specimens. The thinnest parts produced had the largest pores and the highest scatter of elongation values. In these cases, also the sub-contour porosity was observed. Part thickness affected pores’ size and results repeatability but not total porosity. The two-step heat-treatment (solutionizing and age-hardening) exhibited the highest yield and ultimate tensile strength.

Practical implications
The microstructure and local mechanical properties were studied on L-PBF platform with deposited walls of various thicknesses. Subsequently, a detailed analysis was conducted on real components (impellers) made of maraging steel, commonly used in tooling, automotive and aerospace industries.

Originality/value
The broadly understood quality of manufactured parts is crucial for their reliable and long-lasting operation. The findings presented in the manuscript allow the readers better understanding of the connection between deposition parameters, post-processing, microstructure and mechanical performance of additive manufacturing-processed parts.
Tourism seasonality in small island developing states: evidence from Cyprus
Authors: Berjozkina Galina 
Published: September 2022

PurposeThis paper adopts a thematic approach to a review of the literature relating to seasonality in small island developing states.Design/methodology/approachThe paper uses a qualitative approach by retrieving data from academic sources and official public documents from the Government of Cyprus. Thematic analysis is employed to provide information in relation to the numerical aspects of seasonality through statistics and the steps taken by official tourism authorities to alleviate seasonality.FindingsThe findings reveal a significant seasonality problem in Cyprus, especially in the high season months and stagnation during the low season months in winter. This causes problems at the national economic level and results in unemployment. However, in recent years, the government has been trying to tackle the problem by rebranding the destination for all seasons, offering a broad spectrum of varied activities, such as niche, special interest, and cultural tourism.Originality/valueThe paper offers a review-based perspective on seasonality in small island developing states and discusses the merits of developing all-year-round tourism.
Russian Sanctions and the Banking Sector
Authors: Girardone Claudia 
Published: September 2022

AbstractWestern allies have imposed restrictive measures on Russian banks and threatened harsher sanctions on the finance sector since the annexation of Crimea in 2014. However, this did not impede sanctioned banks reporting record profits, nor deter Russia from invading Ukraine on 24 February 2022. Although the sanctions’ full effectiveness remains in question, the impact of Russia's invasion of Ukraine has not only caused a retreat of foreign banks from mainland Russia, but also ended the international ambitions of the largest Russian banks in Europe and beyond.
Real Men Don't Eat Quiche: Queer Food and Gendered Nationalism in the Late Twentieth‐Century USA
Authors: Cleves Rachel Hope 
Published: September 2022

AbstractMore than simply an international bestseller, Bruce Feirstein's satirical guidebook to masculinity, Real Men Don't Eat Quiche (1982), became a ubiquitous catchphrase of the 1980s. The title's success drew on a long tradition of gendered food nationalism in Anglo‐American culture that associated French cuisine with effete masculinity. During the 1970s, quiche in particular was seen as a quintessentially queer dish, served at brunch spots frequented by gay men. Through analysis of Feirstein's text, as well as the writings of James Beard, Craig Claiborne and others food journalists, this article examines how sexuality, gender, food and nationalism intersected in the late twentieth‐century Anglosphere.
Correlations of switch/sucrose nonfermentable complex mutations with clinical outcomes in advanced non–small cell lung cancer
Authors: Chang Geyun , Li Weihua , Bai Hua , Duan Jianchun , Wang Zhijie , Du Xinyang , Yu Ruofei , Wang Yaxi , Wang Minghao , Zhu Yixiang , Zhang Xue , Li Li , Wan Rui , Wang Jie 
Published: September 2022

AbstractBackgroundThe switch/sucrose nonfermentable complex mutations (SWI/SNF‐mut) are common in non–small cell lung cancer (NSCLC). However, the association of SWI/SNF‐mut with the clinical outcomes of immune checkpoint inhibitors (ICIs), particularly of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs), has not been established.MethodsWe retrospectively collected data of patients at Cancer Hospital Chinese Academy of Medical Sciences. Patients with advanced NSCLC who received programmed cell death protein‐1 or programmed cell death ligand 1 (PD‐[L]1) inhibitors were included in cohort 1 and those with EGFR mutations (EGFR‐mutant) received EGFR‐TKIs monotherapy were included in cohort 2. Two reported Memorial Sloan‐Kettering Cancer Center (MSKCC) cohorts received immunotherapy alone used as the validation for cohort 1. We analyzed the relationship between SWI/SNF alterations and clinical outcomes in each cohort.ResultsIn total, 1162 patients were included, of which 230 patients (19.8%) were identified as SWI/SNF‐mut with the most common genetic alterations being ARID1A (33.4%) and SMARCA4 (28.3%). In cohort 1 (n = 146), patients with co‐mutations of SWI/SNF and Kirsten rat sarcoma oncogene (KRAS) (SWI/SNFmutKRASmut, n = 18) had significantly prolonged progression‐free survival (PFS) (8.6 m vs. 1.9 m; hazard ratio [HR], 0.31; 95% confidence intervals [CI], 0.11–0.83; p = 0.032) to PD‐(L)1 inhibitors monotherapy, which was consistent with the MSKCC cohorts (not reach [NR] vs. 6.3 m; HR, 0.36, 95% CI, 0.15–0.82; p = 0.016). In cohort 2 (n = 205), ARID1A‐mut (n = 16) was associated with improved PFS after EGFR‐TKIs (20.6 m vs. 11.2 m; HR, 0.47, 95% CI, 0.27–0.94; p = 0.023).ConclusionsIn advanced NSCLC, patients with SWI/SNFmutKRASmut seem to benefit more from ICIs. Furthermore, ARID1A‐mut may provide a protective effect to EGFR‐TKIs in EGFR‐mutant patients. However, this is a retrospective single‐institution analysis that requires further validation by large prospective studies.
Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China
Authors: Xu Chunwei , Si Lu , Wang Wenxian , Li Ziming , Song Zhengbo , Wang Qian , Liu Aijun , Yu Jinpu , Fang Wenfeng , Zhong Wenzhao , Wang Zhijie , Zhang Yongchang , Liu Jingjing , Zhang Shirong , Cai Xiuyu , Liu Anwen , Li Wen , Zhan Ping , Liu Hongbing , Lv Tangfeng , Miao Liyun , Min Lingfeng , Chen Yu , Yuan Jingping , Wang Feng , Jiang Zhansheng , Lin Gen , Pu Xingxiang , Lin Rongbo , Liu Weifeng , Rao Chuangzhou , Lv Dongqing , Yu Zongyang , Lei Lei , Li Xiaoyan , Tang Chuanhao , Zhou Chengzhi , Zhang Junping , Xue Junli , Guo Hui , Chu Qian , Meng Rui , Wu Jingxun , Zhang Rui , Hu Xiao , Zhou Jin , Zhu Zhengfei , Li Yongheng , Qiu Hong , Xia Fan , Lu Yuanyuan , Chen Xiaofeng , Ge Rui , Dai Enyong , Han Yu , Pan Weiwei , Luo Jiancheng , Jia Hongtao , Dong Xiaowei , Pang Fei , Wang Kai , Wang Liping , Zhu Youcai , Xie Yanru , Lin Xinqin , Cai Jing , Wei Jia , Lan Fen , Feng Huijing , Wang Lin , Du Yingying , Yao Wang , Shi Xuefei , Niu Xiaomin , Yuan Dongmei , Yao Yanwen , Huang Jianhui , Zhang Yinbin , Sun Pingli , Wang Hong , Ye Mingxiang , Wang Dong , Wang Zhaofeng , Wan Bing , Lv Donglai , Wei Qing , Kang Jin , Zhang Jiatao , Zhang Chao , Yu Genhua , Ou Juanjuan , Shi Lin , Li Zhongwu , Liu Zhefeng , Liu Jing , Yang Nong , Wu Lin , Wang Huijuan , Jin Gu , Yang Liu , Wang Guansong , Fang Meiyu , Fang Yong , Li Yuan , Wang Xiaojia , Zhang Yiping , Ma Shenglin , Wang Biyun , Zhang Xiaotian , Song Yong , Lu Yuanzhi 
Published: September 2022

AbstractGene fusions can drive tumor development for multiple types of cancer. Currently, many drugs targeting gene fusions are being approved for clinical application. At present, tyrosine receptor kinase (TRK) inhibitors targeting neurotrophic tyrosine receptor kinase (NTRK) gene fusions are among the first “tumor agnostic” drugs approved for pan‐cancer use. Representative TRK inhibitors, including larotrectinib and entrectinib, have shown high efficacy for many types of cancer. At the same time, several second‐generation drugs designed to overcome first‐generation drug resistance are undergoing clinical development. Due to the rarity of NTRK gene fusions in common cancer types and technical issues regarding the complexity of fusion patterns, effectively screening patients for TRK inhibitor treatment in routine clinical practice is challenging. Different detection methods including immunohistochemistry, fluorescence in situ hybridization, reverse transcription‐polymerase chain reaction, and (DNA and/or RNA‐based) next‐generation sequencing have pros and cons. As such, recommending suitable tests for individual patients and ensuring the quality of tests is essential. Moreover, at present, there is a lack of systematic review for the clinical efficacy and development status of first‐ and second‐generation TRK inhibitors. To resolve the above issues, our expert group has reached a consensus regarding the diagnosis and treatment of NTRK gene fusion solid tumors, aiming to standardize clinical practice with the goal of benefiting patients with NTRK gene fusions treated with TRK inhibitors.
Integrated spatial models foster complementarity between monitoring programmes in producing large‐scale bottlenose dolphin indicators
Authors: Lauret V. , Labach H. , Turek D. , Laran S. , Gimenez O. 
Published: September 2022

AbstractOver the last decades, large‐scale ecological projects have emerged that require collecting ecological data over broad spatial and temporal coverage. Yet, obtaining relevant information about large‐scale population dynamics from a single monitoring programme is challenging, and often several sources of data, possibly heterogeneous, need to be integrated. In this context, integrated models combine multiple data types into a single analysis to quantify the population dynamics of a targeted population. When working at large geographical scales, integrated spatial models have the potential to produce spatialized ecological estimates that would be difficult to obtain if data were analysed separately. In this study, we illustrate how spatial integrated modelling offers a relevant framework for conducting ecological inference at large scales. Focusing on the Mediterranean bottlenose dolphins (Tursiops truncatus), we combined 21,464 km of photo‐identification boat surveys collecting spatial capture–recapture data with 24,624 km of aerial line transect following a distance sampling protocol. We analysed spatial capture–recapture data together with distance sampling data to estimate the abundance and density of bottlenose dolphins. We compared the performances of the distance sampling model and the spatial capture–recapture model fitted independently to our integrated spatial model. The outputs of our spatial integrated models inform bottlenose dolphin ecological status in the French Mediterranean Sea and provide ecological indicators that are required for regional‐scale ecological assessments like the EU Marine Strategy Framework Directive. We argue that integrated spatial models are widely applicable and relevant to conservation research and biodiversity assessment at large spatial scales.
Market Responses to Private and Public Targets: The Role of Goodwill Valuation*
Authors: Kwon Shin Hyoung , Wang Irene Guannan 
Published: September 2022

AbstractInvestors overprice goodwill value acquired from a private target during a merger and acquisition (M&A) announcement. However, the overpricing of goodwill is corrected in the years following the deal's completion. Our results show that investors predict the decreasing value of goodwill and promptly adjust their pricing regardless of goodwill impairment. The differential market reactions to goodwill between private and public targets are economically significant. The pricing on goodwill obtained from a private target is 47% higher around the announcements and 44% (33%) lower one (two) year(s) after the M&A completion than that from the public target.
Development and internal validation of a model for postoperative morbidity in adults undergoing major elective colorectal surgery: the peri‐operative quality improvement programme (PQIP) colorectal risk model
Authors: Bedford J. , Martin P. , Crowe S. , Wagstaff D. , Santos C. , Singleton G. , Baumber R. , Vindrola‐Padros C. , Vohra R. , Swart M. , Oliver C. M. , Dorey J. , Leeman I. , Moonesinghe S. R. ,   for the peri‐operative quality improvement programme (PQIP) collaborative
Published: September 2022

SummaryOver 1.5 million major surgical procedures take place in the UK NHS each year and approximately 25% of patients develop at least one complication. The most widely used risk‐adjustment model for postoperative morbidity in the UK is the physiological and operative severity score for the enumeration of mortality and morbidity. However, this model was derived more than 30 years ago and now overestimates the risk of morbidity. In addition, contemporary definitions of some model predictors are markedly different compared with when the tool was developed. A second model used in clinical practice is the American College of Surgeons National Surgical Quality Improvement Programme risk model; this provides a risk estimate for a range of postoperative complications. This model, widely used in North America, is not open source and therefore cannot be applied to patient populations in other settings. Data from a prospective multicentre clinical dataset of 118 NHS hospitals (the peri‐operative quality improvement programme) were used to develop a bespoke risk‐adjustment model for postoperative morbidity. Patients aged ≥ 18 years who underwent colorectal surgery were eligible for inclusion. Postoperative morbidity was defined using the postoperative morbidity survey at postoperative day 7. Thirty‐one candidate variables were considered for inclusion in the model. Death or morbidity occurred by postoperative day 7 in 3098 out of 11,646 patients (26.6%). Twelve variables were incorporated into the final model, including (among others): Rockwood clinical frailty scale; body mass index; and index of multiple deprivation quintile. The C‐statistic was 0.672 (95%CI 0.660–0.684), with a bootstrap optimism corrected C‐statistic of 0.666 at internal validation. The model demonstrated good calibration across the range of morbidity estimates with a mean slope gradient of predicted risk of 0.959 (95%CI 0.894–1.024) with an index‐corrected intercept of −0.038 (95%CI −0.112–0.036) at internal validation. Our model provides parsimonious case‐mix adjustment to quantify risk of morbidity on postoperative day 7 for a UK population of patients undergoing major colorectal surgery. Despite the C‐statistic of < 0.7, our model outperformed existing risk‐models in widespread use. We therefore recommend application in case‐mix adjustment, where incorporation into a continuous monitoring tool such as the variable life adjusted display or exponentially‐weighted moving average‐chart could support high‐level monitoring and quality improvement of risk‐adjusted outcome at the population level.
Linear and circular stapled gastrojejunal anastomoses in Roux‐en‐Y gastric bypass: stomal diameter at onset and at long‐term follow‐up
Authors: Campanello Magnus , Lindskog Stefan , Zilling Thomas 
Published: September 2022

AbstractBackgroundIn the laparoscopic Roux‐en‐Y gastric bypass procedure, the gastrojejunal stoma is constructed with either a circular (CSD) or a linear stapling device (LSD). The diameter of the stoma following stapling with the 21 mm CSD is expected to be approximately 12 mm (diameter of the anvil). Measuring the stoma diameter after linear stapling is a little more complex since the remaining opening in the linear anastomosis is closed by hand. The aim of this prospective randomized study was to follow up on changes in the diameter of gastrojejunal stomata after laparoscopic Roux‐en‐Y gastric bypass using either a CSD or an LSD between that at construction and at a long‐term follow‐up of 12–72 months later.MethodsTwenty patients were randomly assigned to gastrojejunostomy with either a 21 mm CSD or a 45 mm LSD. Directly after completion of the surgery, the diameter of the gastrojejunal stoma was measured using a Fogarty occlusion catheter and again at follow‐up 12–72 months later.ResultsFive patients were lost for follow‐up, and 15 patients remained. The mean diameter of the CSD stomata at construction was 19.3 ± 5.3 mm (mean ± SD) and increased to 26.4 ± 6.6 mm at follow‐up after a mean of 46 months (P = 0.02). The corresponding figures for the LSD stomata were 26.2 ± 4.1 mm, increasing to 32.7 ± 3.0 mm also after a mean follow‐up of 46 months (P = 0.03).ConclusionsThe mean diameter of the circular stapled gastrojejunostomy stomata at construction was 20 mm, that is, considerably larger than the 12 mm expected. After a mean of 5 years, the mean diameter had increased by 37%. The mean diameter of the linear stapled stomata increased by 25%.
Reversal of Hartmann's procedure: timelines, preoperative investigations and early outcomes. A single Australian institution's ten‐year experience
Authors: Suthakaran Reshi , Faragher Ian G. , Yeung Justin M. C. 
Published: September 2022

AbstractBackgroundReal‐world data on outcomes following Hartmann's reversal is necessary to help optimize the patient experience. We have explored the timing between the index operation and its reversal; what investigations were carried out prior to this, and the associated short‐term outcomes.MethodsA retrospective study of all patients who underwent Hartmann's reversal from 2010 to 2020 within a tertiary referral centre in Melbourne, Australia. One hundred from a total of 406 (25%) who underwent an emergency Hartmann's procedure had a subsequent reversal. Complete patient data was available for 83 of these patients.ResultsThe average patient age was 60 years, and the median time for reversal was 14.0 (IQR 10–23) months. Seventy‐nine of 83 (95%) reversals had a preoperative endoscopic evaluation of both their rectal stump and a complete colonoscopy. Stoma stenosis (n = 2), patient refusal (n = 1) and emergency reversal (n = 1) were cited reasons for not undergoing preoperative endoscopic evaluation. A third (n = 28, 34%) had a computed tomography prior to reversal; the majority was due to their underlying cancer surveillance (n = 21, 75%). Reversal was associated with a morbidity rate of 47% (n = 39). Surgical site infections (SSIs) (n = 21, 25%) were the most common type of complications encountered, with the majority being superficial (n = 15, 71%). SSIs were associated with steroid use (5/21 versus 4/62, p = 0.03) and greater hospital length of stay (6 versus 10 days, p = 0.03).ConclusionOnly a quarter of emergency Hartmann's procedures within our institution were reversed. A significant proportion developed postoperative complications. Surgical site infection was the most common morbidity.
Technical insights to multivisceral resections using the da Vinci Xi
Authors: Ngu James Chi‐Yong , Shannon Nicholas Brian , Eu Ernest Wencong , Lee Lip Seng , Tan Siong San , Lim Sey Kiat Terence , Ng Foo Cheong , Chiow Adrian Kah Heng 
Published: September 2022

AbstractBackgroundThere have been few reports on the feasibility and safety of robotic multivisceral surgeries. The da Vinci Xi boasts significant upgrades that improve its applicability in combined resections. We report our early experience of multivisceral, multi‐quadrant resections with the Xi system.MethodsBetween May 2015 and August 2019, 13 multivisceral resections were performed. Patient demographics, procedural data, and perioperative outcomes were evaluated.ResultsThe procedures were completed at a median operative time of 290 (range, 210–535) minutes. The median postoperative length of hospital stay was 3.5 (range, 2–7) days. There was one case of readmission for anastomotic leak, but no positioning injuries, external robot arm collisions or issues arising from trocar position. There were no cases of perioperative mortality.ConclusionMultivisceral resections can be safely accomplished using the Xi. Further studies are necessary to ascertain whether there are benefits of the robotic approach over conventional laparoscopy in these complex cases.
Wearable and implantable artificial kidney devices for end‐stage kidney disease treatment: Current status and review
Authors: Groth Thomas , Stegmayr Bernd G. , Ash Stephen R. , Kuchinka Janna , Wieringa Fokko P. , Fissell William H. , Roy Shuvo 
Published: September 2022

AbstractBackgroundChronic kidney disease (CKD) is a major cause of early death worldwide. By 2030, 14.5 million people will have end‐stage kidney disease (ESKD, or CKD stage 5), yet only 5.4 million will receive kidney replacement therapy (KRT) due to economic, social, and political factors. Even for those who are offered KRT by various means of dialysis, the life expectancy remains far too low.ObservationResearchers from different fields of artificial organs collaborate to overcome the challenges of creating products such as Wearable and/or Implantable Artificial Kidneys capable of providing long‐term effective physiologic kidney functions such as removal of uremic toxins, electrolyte homeostasis, and fluid regulation. A focus should be to develop easily accessible, safe, and inexpensive KRT options that enable a good quality of life and will also be available for patients in less‐developed regions of the world.ConclusionsHence, it is required to discuss some of the limits and burdens of transplantation and different techniques of dialysis, including those performed at home. Furthermore, hurdles must be considered and overcome to develop wearable and implantable artificial kidney devices that can help to improve the quality of life and life expectancy of patients with CKD.