bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of threshold value of protective level of class G antibodies to SARS-COV‑2 in late phase of immune response in COVID‑19 convalescents
Authors: Alkhutova N. A. , Kovyazina N. A. , Davydova D. I. , Aleksanin S. S. , Rybnikov V. Yu. 
Published: April 2022

Determining the effectiveness and duration of humoral immunity to SARS-CoV‑2 is of great importance for the management tactics and forecasting of the COVID‑19 pandemic. However, it is important to understand that the high concentration of antibodies, which is characteristic of an acute immune response (including after vaccination), will not persist in its late stage of “memory”. The level of antibodies at the end of the acute phase of the immune response inevitably decreases, and then, having reached a certain limit, it stabilizes in most people.The purpose of this study is to substantiate the threshold value of the “protective” level of antibodies to SARS-CoV‑2 when using the SARS-CoV‑2- IgG-ELISA-BEST reagent system of Vector-Best JSC, Novosibirsk, Russia.The results of our study confirmed that 6–10 and even 18 months after the COVID‑19 disease and 6 months after vaccination, the antibody level positivity index (IP) remained relatively constant and comparable. Taking into account the risks of adverse reactions and complications caused by excessive immunization with repeated administration of the vaccine against a background of high antibody levels, it is advisable to focus on the average value of the level of antibodies of the late phase of the immune response, taking this level as the threshold value of “protective” immunity. The data obtained by us together with the results of foreign authors suggest that both infection with SARS-CoV‑2 and vaccination, in most cases, lead to the formation of long-term humoral immunity, which corresponds to the range of concentration of SARS-CoV‑2-IgG equal to IP=7,77 ± 1,64 or 102,63 ± 29,31 BAU / ml.
Evaluation of effectiveness of humoral immune response after vaccination with ‘CoviVaс’
Authors: Kazakov S. P. , Reshetnyak D. V. , Davydova N. V. , Putkov S. B. 
Published: April 2022

Determining the efficiency of the principal means of specific immunoprophylaxis in forming thepost-vaccinal immunity against the new coronavirus infection (СOVID‑19) is a very important and topical problem. Solving it involves the evaluation of the efficiency and choosing the laboratory diagnostics technique for an adequate estimation of the nature and the level of thepost-vaccinal immune response (PIR).Research objectives. Evaluating efficiency of the humoral PIR involving theproduction of specific antibodies in patients vaccinated with ‘CoviVac’using quantitative andsemi-quantitative test systems developed by Russian and international companies.Material and methods. The level of antibodies matching the principal known antigens of the SARS-CoV‑2 virus was measured. The probes were taken in a group of 103 persons 22–30 days after vaccination. The techniques used were the principal immunochemical ones (enzymelinkedimmunosorbent assay (ELISA) and chemiluminescent microparticle immunoassay (CMIA)). The nature and the level of the PIR in terms of these antibodies’ production was studied, and the adequacy of the diagnostic techniques applied was evaluated, wherefore the result convergence was studied, and the techniques’ cross-sensitivity and specificity were determined.Results. Insufficient level of PIR in terms of producing antibodies against SARS-CoV‑2 after vaccination with‘CoviVac’was established. The levels of antibodies were found to be not highenough to ensure a reliable immunity against the Covid‑19. However, a highdegree of correlation between the results of different quantitative techniques for measuring theantibodies matching the S-protein and its BRD of the SARS-CoV‑2 virus was determined. Arather high convergence of the results of the quantitative and semi-quantitative techniques usedfor studying this type of antibodies was found.Conclusions. The PR upon the vaccination with the ‘CoviVac’ is characterized by insufficientintensity level in terms of forming the long-living IgG antibodies with surface antigens of SARS-CoV‑2. In particular, the antibody count, which is generally considered capable of ensuringreliable protection, was not reached. Efficiency of the immunochemical testsystems used in this study is high enough and can provide an adequate estimate of the PIR after the vaccination with ‘CoviVac’ .
Biomarkers of non-specific inflammation and atherosclerosis of carotid arteries in obstructive sleep apnea syndrome
Authors: Polonskiy E. L. , Zybina N. N. , Tikhomirova O. V. , Lomova I. P. 
Published: April 2022

Purpose of study. Identification of significant laboratory markers for the development of atherosclerosis (AS) of the carotid arteries (CA) in patients with obstructive sleep apnea syndrome (OSAS).Materials and methods. 152 male patients were examined, 84 of whom, according to polysomnography (PSG), were diagnosed with OSAS. Diagnosis of AS CA was performed by triplex scanning. The complex of laboratory studies included the assessment of lipid metabolism, the concentration of highly sensitive C-reactive protein (hsCRP), interleukin‑1β (IL‑1β), interleukin‑6 (IL‑6) and interleukin‑10 (IL‑10) in blood serum.Results. In patients with OSAS, a statistically significant increase in the complex of proatherogenic factors was found: hsCRP, pro-inflammatory cytokines, ratio of apoproteins and atherogenic coefficient compared with patients without OSAS despite the absence of differences in the severity of atherosclerotic lesions of the carotid arteries in these groupsConclusion. The development of OSAS is associated with severe lipid metabolism disorders and activation of nonspecific inflammation, which determines an increased risk of atherosclerosis in this group of patients.
Horned Melon Pulp, Peel, and Seed: New Insight into Phytochemical and Biological Properties
Authors: Šovljanski Olja , Šeregelj Vanja , Pezo Lato , Tumbas Šaponjac Vesna , Vulić Jelena , Cvanić Teodora , Markov Siniša , Ćetković Gordana , Čanadanović-Brunet Jasna 
Published: April 2022

Artificial neural intelligence was established for the estimation, prediction, and optimization of many agricultural and food processes to enable enhanced and balanced utilization of fresh and processed fruits. The predictive capabilities of artificial neural networks (ANNs) are evaluated to estimate the phytochemical composition and the antioxidant and antimicrobial activity of horned melon (Cucumis metuliferus) pulp, peel, and seed. Using multiobjective optimization, the main goals were successively achieved through analysis of antimicrobial potential against sensitive microorganisms for peel (Bacillus cereus, Pseudomonas aeruginosa, Aspergillus brasiliensis, and Penicillium aurantiogriseum), pulp (Salmonella enterica subsp. enterica serotype Typhimurium), and seed samples (Saccharomyces cerevisiae and Candida albicans), and its connection with phytochemical and nutritional composition and antioxidant activity. The highly potent extracts were obtained from peels which represent a waste part with strong antioxidant and antifungal capacity. Briefly, the calculated inhibition zone minimums for sensitive microorganisms were 25.3–30.7 mm, while the optimal results achieved with carotenoids, phenolics, vitamin C, proteins, lipids, DPPH, ABTS, and RP were: 332.01 mg β-car/100 g, 1923.52 mg GAE/100 g, 928.15 mg/100 g, 5.73 g/100 g, 2.3 g/100 g, 226.56 μmol TE/100 g, 8042.55 μmol TE/100 g, and 7526.36 μmol TE/100 g, respectively. These results imply the possibility of using horned melon peel extract as an antioxidant and antifungal agent for food safety and quality.
Psychometric Validation of the Internet Gaming Disorder-20 Test among Ecuadorian Teenagers and Young People
Authors: Andrade Livia I. , Viñán-Ludeña Marlon Santiago , Alvarado Julio 
Published: April 2022

Excessive internet gaming in high prevalence is a very common problem that has been increasing in recent years, especially in teenagers and university students. However, there is a lack of psychometric evaluation for Internet Gaming Disorder in the Latin American context, particularly in Ecuador. This paper aims to examine the psychometric properties of the Spanish version of the Internet Gaming Disorder test (IGD-20 test) in university and high school students (n=2931, Mage=15.99, 57.22% male and 42.51% female). The validation process was performed using one, two, five and six factors taking into account the Spanish, Chinese, Korean, Arabic and Turkish contexts. After checking the models proposed to date, the best fit model was the one with a single factor. Using two samples according to gender (male, female), the invariance has been confirmed with an excellent internal consistency. All, α=0.94; Male, α=0.93; Female, α=0.93). Furthermore, we performed correlation analyses between the IGD-20 Test and socio-demographic variables, and finally, the IGD-20 Test applied to Ecuadorian teenagers and young people demonstrated good psychometric properties.
Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer Based on Functional Assessment and NIRS Analysis
Authors: Durán-Gómez Noelia , López-Jurado Casimiro Fermín , Nadal-Delgado Marta , Pérez-Civantos Demetrio , Guerrero-Martín Jorge , Cáceres Macarena C. 
Published: April 2022

Background: Chemotherapy-related cognitive impairment (CRCI), or “chemobrain,” isdefined as a phenomenon of cognitive deficits in cancer patients after chemotherapy and is characterized by deficits in areas of cognition, including memory, attention, speed of processing, and executive function, which seriously affect quality of life. The purpose of this study is to investigate the impact of CRCI in breast cancer (BC) patients in chemotherapy treatment (CT+) or not (CT−) and to analyze their relationship with detectable objective changes in cerebral activity during the execution of a phonological and semantic verbal fluency task (PVF and SVF). Methods: An observational, cross-sectional study was carried out at Badajoz University Hospital (Spain). A total of 180 women with BC were included. We used Cognitive Scale (FACT-Cog) for neuropsychological subjective assessment, obtaining scores of perceived cognitive impairment (PCI), and near-infrared spectroscopy system (NIRS) for neuropsychological objective assessment during a verbal fluency task (PVF and SVF), determining alterations in the prefrontal cortex (PFC) assessed as changes in regional saturation index (rSO2). Results: A total of 41.7% percent of the patients in the sample had PCI. CT+ was significantly associated with a worse impact in PCI (X¯ = 50.60 ± 15.64 vs. X¯ = 55.01 ± 12.10; p = 0.005). Average rSO2 decreased significantly in CT+ (X¯ = 63.30 ± 8.02 vs. X¯ = 67.98 ± 7.80; p < 0.001), and BC patients showed a significant decrease in PVF and SVF on average (X¯ = 41.99 ± 9.52 vs. X¯ = 47.03 ± 9.31, and X¯ = 33.43 ± 11.0 vs. X¯ = 36.14 ± 10.68, respectively; p < 0.001). Conclusions: Our findings suggest that cognitive impairments in the domain of executive functioning exist among patients with BC who received CT. The results corroborate the hypothesis that CT is an important factor in cognitive impairment in patients with BC, which has been demonstrated by both subjective (PCI) and objective (PVF, SVF, and rSO2) neuropsychological measures. The combination of doxorubicin, cyclophosphamide, and docetaxel induce cognitive impairment.
Staphylococcus warneri: brief literature review / Staphylococcus warneri: breve revisão da literatura
Authors: Karam Bruna Ribeiro Sued , Ribeiro Paula Marcele Afonso Pereira 
Published: April 2022

Coagulase-negative Staphylococcus warneri is an opportunistic pathogen that is capable of causing several infections, especially in patients with indwelling medical devices. Antimicrobial resistance is a global challenge for the treatment of infections caused by staphylococci. The most important virulence factor of CoNS is the biofilm-producing ability. This brief literature review discusses aspects of the antimicrobial resistance and virulence factors of the Staphylococcus warneri. Literature about the Staphylococcus warneri listed in PubMed between 2011 and 2021 was reviewed. Staphylococcus warneri is a part of the normal flora of the skin, especially the nares, head, legs, and arms. The importance of S. warneri as a modern-day pathogen is growing, as it has established itself as a successful nosocomial pathogen. S. warneri isolates from these infections are generally resistant to beta-lactam antimicrobial agents. The virulence of S. warneri have been suggested to be multifactorial, including adhesins, enzymes, extracellular toxins, capsule, iron uptake systems, virulence regulators and to adhere to produce biofilm, invade and destroy epithelial cells. The pathogenetic mechanisms of infections their mechanisms of bacterial persistence and evasion of the host’s immune system have not yet been clearly elucidated. Only with deeper studies, which will allow a more comprehensive understanding of its physiological characteristics, will it be possible to design effective strategies against S. warneri.
Pengaruh Kepemimpinan dan Lingkungan Kerja terhadap Kinerja melalui Komitmen sebagai Variabel Intervening
Authors: Mainita Mainita 
Published: April 2022

Penelitian ini bertujuan untuk mengetahui pengaruh kepemimpinan dan lingkungan kerja terhadap kinerja melalui komitmen sebagai variabel intervening pada Satpol PP Pasaman Barat. Metode yang digunakan adalah analisis regresi linier berganda dan analisis jalur, dengan mengedarkan kuesioner sebanyak 68 responden. Hasil penelitian menunjukkan bahwa kepemimpinan dan lingkungan kerja berpengaruh positif dan signifikan terhadap komitmen pada Satpol PP Pasaman Barat. Kepemimpinan, lingkungan kerja, dan komitmen juga memiliki pengaruh yang positif dan signifikan terhadap kinerja Satpol PP Pasaman Barat. Komitmen memediasi pengaruh kepemimpinan terhadap kinerja, dibuktikan dengan nilai pengaruh langsung lebih kecil dari nilai pengaruh tidak langsung. Komitmen memediasi pengaruh lingkungan kerja terhadap kinerja, dibuktikan dengan nilai pengaruh langsung lebih kecil dari nilai pengaruh tidak langsung. Penelitian ini menyarankan kepada Satpol PP Pasaman Barat untuk lebih meningkatkan komitmen, kepemimpinan dan lingkungan kerja sehingga diharapkan kinerja pegawai meningkat.
Penyalahgunaan Kuasa Imamat Dalam Kasus Sexual Abuse
Authors: Renda Martinus , Bilung Ronalius , Kabalesy Yoseph , Hegemur Johanes , Tinambunan Edison R. L. 
Published: April 2022

Abstract
This study focuses on the actions of the priesthood by priests related to the prevalence of sexual abuse cases among the clergy. The disgraceful acts committed by the priests have become a disgrace that the Church has to endure to this day. The church as a continuation of Christ's mission in the world feels the need to reorganize and reorganize by taking a firm stance in resolving the current struggle. To maintain her holiness, the Church first takes a stance of refusing and will not allow the clergy to continue to create sin in her body. Through its leaders, the Church continues to seek to voice that priests should take the path of repentance and return to the essence of priestly life which has united it with the priesthood of Christ. In addition, the Church lovingly welcomes and accepts those who have been victims of sexual abuse by priests. The Church hopes that they will continue to love the Church and believe that the Church is a home that protects and protects them from all crimes and inhumane treatment. As a form of feeling, the Church will continue to stand for justice and respect the rights and dignity of life for victims of sexual harassment, providing assistance, assistance, and healing service to rediscover the meaning of life that is valuable and worthy.
Keywords: priesthood power, sexual harassment, ministerial priesthood, pastoral.
Abstrak
Studi ini menaruh perhatian pada tindakan penyalahgunaan kuasa imamat yang dilakukan oleh para imam terkait dengan merebaknya kasus sexual abuse dikalangan kaum klerus. Tindakan tidak terpuji yang dilakukan oleh para imam telah menjadi aib yang harus ditanggung oleh Gereja hingga saat ini. Gereja sebagai kelanjutan dari misi Kristus di tengah dunia merasa perlu untuk membenah dan menata dirinya kembali dengan mengambil suatu sikap tegas dalam menyelesaikan pergulatan yang tengah terjadi. Demi menjaga kekudusannya, Gereja pertama-tama mengambil suatu sikap untuk menolak dan tidak akan pernah membiarkan kaum klerus terus menerus menciptakan dosa di dalam tubuhnya. Melalui para pemimpinnya Gereja terus berupaya menyuarakan agar para imam mengambil jalan tobat dan kembali kepada hakikat hidup imamat yang telah mempersatukannya dengan imamat Kristus. Di samping itu Gereja dengan penuh cinta menyambut dan menerima mereka yang telah menjadi korban sexual abuse yang dilakukan oleh para imam. Gereja berharap mereka tetap mencintai Gereja dan percaya bahwa Gereja menjadi rumah yang akan menjaga dan melindungi mereka dari segala kejahatan dan perlakuan yang tidak berprikemanusiaan. Sebagai bentuk rasa tanggungjawabnya, Gereja akan terus berdiri di atas keadilan dan menghormati hak serta martabat hidup para korban sexual abuse, memberikan pendampingan, pertolongan serta tindakan penyembuhan sehingga menemukan kembali makna hidup yang berharga dan bernilai.

Kata kunci: kuasa imamat, sexual abuse, imamat ministerial, pastoral.
Menggagas Fusi Horison Dalam Hermeneutika Hans Georg Gadamer Sebagai Model Saling Memahami Bagi Dialog Antarbudaya Dengan Relevansi Pada Pancasila Sebagai Landasan Dialogis Filosofis
Authors: Prasetyono Emanuel 
Published: April 2022

ABSTRACT
Fusion of horizons is the encounter between horizon of the past and of the present in the projection to the future. It takes place in all kind of understanding which is influenced by historically effected consciousness. In the realm of individual activity, fusion of horizons is characterized by formative and existential aspect as continual learning on how to be rooted in one’s own history and culture. Formatively, fusion of horizons leads to build one’s own character to be man of dialogue which is capable of adapting himself with his cultural environment. In the realm of social life, fusion of horizons deals with dialogue in the atmosphere of each other understanding culturally. Practically, dialogue is the formative praxis which enables those who involve in it to understand each other the relationship among themselves and their culture. The concept of the fusion of horizons has the role of bridging different views through hermeneutical and dialogical approach which is based on the process of pursuing meaning and the transformation of prejudices. As the result, the horizons of those who involve in a dialogue will be transformed richly and largely.

ABSTRAK
Fusi horison adalah perjumpaan antara horison masa lampau dan horison masa kini yang terjadi dalam seluruh aktivitas memahami yang dipengaruhi oleh sejarah pengaruh atas dasar dampak-dampak historis dari masa lalu dan proyeksi ke arah masa depan. Dalam ranah individual, fusi horison bersifat formatif dan eksistensial sebagai sarana pembelajaran secara terus-menerus untuk berakar pada sejarah dan jati diri budaya sendiri. Proyeksinya terarah kepada pembentukan karakter diri sebagai sosok manusia yang berdialog dan mampu beradaptasi dengan lingkungan di sekitarnya. Dalam ranah sosial, fusi horison mewujud dalam aktivitas saling memahami dalam dialog. Praksis berdialog adalah bagian dari formasi manusia untuk mengenal dengan baik hubungan-hubungan antara dirinya, sesamanya, dan kebudayaannya. Konsep fusi horison menjembatani horison-horison yang berbeda melalui pendekatan dialogis-hermeneutik atas dasar proses pencarian makna-makna dan transformasi prasangka-prasangka. Hasil dari proses fusi horison adalah transformasi horison ke dalam jangkauan pandangan yang lebih luas.
Kata Kunci: Budaya, Dampak Historis, Dialog, Fusi Horison, Prasangka, Saling Memahami.
History and Jurisprudence of the Maqāṣid
Authors: Kamali Mohammad Hashim 
Published: April 2022

This article, which was originally delivered as a keynote address at the AJIS symposium on “Theory and Uses of Maqāṣid al-Sharī‘a” in May 2021, begins with a review of the Qur’an and Sunna on the maqāṣid, followed by a similar review of the history of maqāṣid and salient contributors to its jurisprudence, while drawing attention to its prolonged marginalization in legal theory. The recent revival of maqāṣid in the latter part of the twentieth century is reviewed next, followed by a note on the special appeal of the maqāṣid, the end of their historical neglect, and a great deal of renewed interest by contemporary Muslim scholars. The relationship of uṣūl al-fiqh to maqāṣid has also been the subject of renewed interest, as to whether it is one of continued domination or one of complementarity between them. Then follows a section on the classification of maqāṣid, how they are appraised and prioritized in relationship to one another; and a review of methodological indicators that can help withthe appraisal and ranking of the maqāṣid and their application to new issues. The article concludes with an account of ijtihād maqāṣidi and its application to contemporary issues.
The Effectiveness of Anger Management Training in Reducing Bullying Behavior among School-Age Children
Authors: Tryastuti Dini 
Published: April 2022

Introduction: Bullying is frequently violent behavior by an individual or group against a weak individual. Bullying behavior may have a negative effect on both a bully and a victim. The Incident of bullying has increased. Therefore it needs to get serious attention. Anger management training was one intervention for decreasing bullying behavior. The prior intervention rarely used anger management that included calming techniques, cognitive restructuring, and assertiveness (Communication Technique). Objective: This study aimed to examine the effect of anger management training in reducing bullying behavior in school-age children in Cimanggis Depok City. Method: The design of this study was a quasi-experiment pre-posttest with a control group. The study sample consisted of 80 elementary school students who have experienced bullying others, the intervention group had 40 respondents, and the control group had 40 respondents. The sample of the study was selected by random sampling technique. Result: The result showed that anger management training effectively reduced bullying behavior in school-age children (p 0,001). Recommendation: It was recommended to use anger management training in reducing bullying behavior among school-age children