bluuebunny/crossref_metadata_2025_split huggingface dataset:
Možnosti určování vročení standardních gramofonových desek z diskotéky R. A. Dvorského ve sbírce Národního muzea – Českého muzea hudby s pomocí diskografických zdrojů
Authors: Studničný Michal 
Published: November 2022

Účel – Cílem předkládaného odborného článku je nastínění základních postupů při katalogizaci standardních gramofonových desek, a to zejména v souvislosti s řešením problematiky vročení. Datace nahrávek je jedním z podstatných (a povinných) kroků pro správnou identifikaci a tím i katalogizaci zvukových dokumentů ve fondech paměťových institucí v ČR. U některých typů zvukových dokumentů, jako jsou např. i historické gramofonové desky, naráží však samotný postup při určování datace na mnohá úskalí. Způsoby řešení problematiky vročení a jejich aplikace v katalogizační praxi budou v textu představeny na vzorku z vybrané části sbírky fonotéky Národního muzea – Českého muzea hudby (dále jen NM-ČMH), konkrétně pak osobní diskotéky významné osobnosti populární hudby první poloviny 20. století, R. A. Dvorského. Design/metodologie/přístup – Na základě představení možností určování datace z etiket standardních gramofonových desek, a při užití různých typů specializovaných zdrojů (historických katalogů, diskografií, elektronických databází, specializovaných příruček atd.) byla dle pravidel RDA minimálního záznamu a ve formátu MARC 21 katalogizována sbírka standardních gramofonových desek ze sbírky diskotéky R. A. Dvorského. V textu jsou představeny vybrané příklady využití různých typů zdrojů a následného zápisu vročení do katalogizační systému. Výsledky – Zamýšlenými výsledky jsou: 1) aplikace specializovaných zdrojů při vročení standardních gramofonových desek a 2) ukázka modelových příkladů katalogizace standardních gramofonových dese ze sbírek Národního muzea – Českého muzea hudby dle pravidel RDA ve formátu MARC 21. Originalita/hodnota – Hlavním přínosem článku je ukázka popisu a katalogizace standardních gramofonových desek ze sbírek Národního muzea – Českého muzea hudby dle minimálního záznamu a pravidel RDA ve formátu MARC 21 na modelových příkladech vybraných gramofonových desek z diskotéky R. A. Dvorského. Dalším přínosem je přehled aplikace několika druhu pomocných zdrojů, které jsou klíčové při určení datace standardních gramofonových desek. Takové typy zdrojů mohou sloužit katalogizátorům a dokumentátorům paměťových institucí jako pomůcka při katalogizaci, rekatalogizaci a evidenci fondů a sbírek standardních gramofonových desek. Lze tak retrospektivně nahrávky datovat, což doplňuje nedostatečný popis zvukového nosiče např. při různých projektech. Klíčová slova: katalogizace, zvukové dokumenty, standardní gramofonová deska, vročení, diskografie, katalogy, databáze, Rudolf Antonín Dvorský
Determination of Genotoxic Impurities N-nitrosamine's in Efavirenz Drug Substance Using Rp-Hplc Technique
Authors: Sravanthi A. Devi , Bharath P. , Kiranmayi P. , Ramachandran D. 
Published: November 2022

Aim: The main purpose of the research is to develop a effective, sensitive, economical and simple reverse phase HPLC method for the determination of genotoxic N-Nitrosamine's impurities in Efavirenz drug substance.
Study Design: HPLC based quantification studies
Place and Duration of Study: Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh between April 2022 and August 2022.
Methodology: Determination of genotoxic N-Nitrosamine's in Efavirenz drug substance. N-Nitrosamine's impurities were determined by RP-HPLC method using Zorbax SB C18 (150x4.6mm, 3.5µ) column as stationary phase. Column temperature maintained 25°C, injection volume 20 µL, flow rate 1.0 mL/min and sample cooler temperature 5°C and run time was 15 minutes. The mixture of 0.1% formic acid buffer and methanol in the ratio of 50:950 (v/v) was used as mobile phase. wavelength 240 nm. respectively.
Results: There is no interference of blank at N-Nitrosamine's impurities peaks. The elution order and the retention times of impurities and Efavirenz obtained from individual standard preparations and mixed standard preparations are comparable.
The limit of detection (LOD) and limit of quantitation (LOQ) for NDMA 0.03 & 0.09 µg/mL, NDEA 0.02 & 0.06 µg/mL and NDIPA 0.03 & 0.09 µg/mL respectively.
The linearity results for N-Nitrosamine's impurities in the specified concentration range are found satisfactory, with a correlation coefficient greater than 0.99.Calibration curve was plotted and correlation co-efficient for impurities found to be 1.000, 1.000 and 1.000 respectively.
The accuracy studies were shown as %recovery for N-Nitrosamine's impurities at specification level. The limit of % recovered shown is in the range of 80 and 120% and the results obtained were found to be within the limits. Hence the method was found to be accurate.
The technique has been validated in accordance with ICH rules, and all validation parameters meet the acceptance criteria of the ICH Q2 specification.
Conclusion: According to ICH guidelines, an RP-HPLC method that can assess genotoxic Nitrosoamines in Efavirenz at trace level concentration has been established. The method's specificity, precision, linearity, and accuracy ensured its efficacy. As a result, the technique is appropriate for the goals it was designed to achieve and can be successfully used for release testing of efavirenz into the market.
Daily Low-Dose Aspirin and Risk of Serious Falls and Fractures in Healthy Older People
Authors: Barker Anna L. , Morello Renata , Thao Le Thi Phuong , Seeman Ego , Ward Stephanie A. , Sanders Kerrie M. , Cumming Robert G. , Pasco Julie A. , Ebeling Peter R. , Woods Robyn L. , Wolfe Rory , Khosla Sundeep , Hussain Sultana Monira , Ronaldson Kathlyn , Newman Anne B. , Williamson Jeff D. , McNeil John J. 
Published: November 2022

ImportanceFalls and fractures are frequent and deleterious to the health of older people. Aspirin has been reported to reduce bone fragility and slow bone loss.ObjectiveTo determine if daily low-dose aspirin (100 mg) reduces the risk of fractures or serious falls (fall-related hospital presentations) in healthy older men and women.Design, Setting, and ParticipantsThis substudy of a double-blind, randomized, placebo-controlled trial studied older adult men and women in 16 major sites across southeastern Australia. The ASPREE-FRACTURE substudy was conducted as part of the Australian component of the ASPREE trial. Between 2010 and 2014 healthy (free of cardiovascular disease, dementia or physical disability), community-dwelling volunteers aged 70 years or older were recruited to participate in the ASPREE trial. Potentially eligible participants were identified by medical practitioners and trial personnel and were then sent a letter of invitation to participate. Interested participants were screened for suitability. Eligible participants with medical practitioner authorization and adherent to a 4-week run-in medication trial were randomized. Data were analyzed from October 17, 2019, to August 31, 2022.InterventionsParticipants in the intervention group received a daily dose of oral 100 mg enteric-coated (low-dose) aspirin. The control group received a daily identical enteric-coated placebo tablet.Main Outcomes and MeasuresThe primary outcome of ASPREE-FRACTURE was the occurrence of any fracture. The secondary outcome was serious fall resulting in hospital presentation.ResultsIn total, 16 703 people with a median (IQR) age of 74 (72-78) years were recruited, and 9179 (55.0%) were women. There were 8322 intervention participants and 8381 control participants included in the primary and secondary outcome analysis of 2865 fractures and 1688 serious falls over the median follow-up of 4.6 years. While there was no difference in the risk of first fracture between the intervention and control participants (hazard ratio, 0.97; 95% CI, 0.87-1.06; P = .50), aspirin was associated with a higher risk of serious falls (total falls 884 vs 804; incidence rate ratio, 1.17; 95% CI, 1.03-1.33; P = .01). Results remained unchanged in analyses that adjusted for covariates known to influence fracture and fall risk.Conclusions and RelevanceIn this substudy of a randomized clinical trial, the failure of low-dose aspirin to reduce the risk of fractures while increasing the risk of serious falls adds to evidence that this agent provides little favorable benefit in a healthy, White older adult population.Trial RegistrationThis substudy is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12615000347561).
Identification of novel meQTLs strongly associated with rheumatoid arthritis by large‐scale epigenome‐wide analysis
Authors: Tang Guoping , Sun Chen , Lv Hongchao , Zhang Mingming , Jiang Yongshuai , Xu Jing 
Published: November 2022

Rheumatoid arthritis (RA) is highly heritable, and previous studies have suggested that genetic variation may affect susceptibility to RA by altering epigenetic modifications (e.g. DNA methylation). Here we examined how genetic variation influences DNA methylation (DNAm) in RA by integrating individual genetic variation and DNAm data. Epigenome‐wide meQTL (methylation quantitative trait loci) analysis was performed on 354 RA patients and 335 controls, scanning 30,101,744 relationships between 62 SNPs and 485,512 DNA methylation sites. Two regulatory relationship pairs (FDR < 0.05) showed very strong associations with RA risk. One was rs10796216‐cg00475509, and the DNAm decreased by 0.0168 per addition of allele rs10796216‐A. The other was rs6546473‐cg13358873, for which a 0.0365 reduction of DNAm at cg13358873 was observed for each addition of allele rs6546473‐A, and lower DNAm was found to be significantly associated with RA risk (P = 2.0407e‐28). Moreover, both pairs of meQTL showed a strong regulatory relationship only in RA samples, so they can be subsequently considered as risk markers for RA. In conclusion, our integrated analysis of genetic and epigenetic variation suggests that genetic variation may affect the risk of RA by regulating DNA methylation levels. Alterations of DNAm at cg00475509 and cg13358873 loci conferred by rs10796216‐A and rs6546473‐A allele may suggest a potential risk for RA. Our results deepen our understanding of the genetic and epigenetic mechanisms of RA and provide novel associations that can be further investigated in future studies.
Mimicking tracing actions enhances young children's mathematical learning
Authors: Smyrnis Eleni , Ginns Paul , Bobis Janette 
Published: November 2022

AbstractLearning mathematical concepts and procedures typically requires extended cognitive effort, presenting a challenge for many children. People can make tracing actions with the index finger, as well as mimic another's movements, with little or no conscious effort. From the perspective of cognitive load theory, such biologically primary actions may facilitate learning biologically secondary concepts and skills requiring extensive cognitive effort, such as mathematics. The present study investigated effects on learning processes and outcomes of students mimicking a teacher's tracing actions from the perspective of an evolutionarily informed cognitive load theory. One hundred and thirteen Grade Two children learned about number lines, either observing a teacher tracing out elements of worked examples with her index finger, or mimicking the teacher's tracing actions with their own index finger. In accord with hypotheses, results indicated enhanced performance due to mimicking on cognitive load, motivation, and post‐test performance. Directions for future research are discussed.
Controllable Modulation of Efficient Phosphorescence Through Dynamic Metal‐Ligand Coordination for Reversible Anti‐Counterfeiting Printing of Thermal Development
Authors: Dai Wenbo , Li Gengchen , Zhang Yongfeng , Ren Yue , Lei Yunxiang , Shi Jianbing , Tong Bin , Cai Zhengxu , Dong Yuping 
Published: November 2022

AbstractDynamically tunable room‐temperature phosphorescence (RTP) organic materials have attracted considerable attention in recent years due to their great potential over a wide variety of advanced applications. However, the precise regulation of the intersystem crossing (ISC) process for efficient RTP materials with dynamically modulated properties in a rigid environment is challenging. Herein, an effective strategy for RTP material preparation with controllably regulated properties is developed via the construction of dynamic metal‐ligand coordination in a host‐guest doped system. The coordination interaction promotes ISC and phosphorescence emission of the guest, thus allowing the modulation of the photophysical properties of doped materials by changing the doping ratio and Zn2+ counterions. By taking advantage of the reversible metal‐ligand coordination interaction, the coordination‐activated, and dissociation‐deactivated RTP is dynamically manipulated. With the unique Zn2+‐responsible RTP enhancement materials, the anti‐counterfeiting applications of thermal development, and color inversion have been constructed for inkjet printing of high‐resolution patterns with high reversibility for many write/erase cycles. The results show that dynamic metal‐ligand coordination strategy is a promising approach for achieving efficient RTP materials with controllably modulated properties.
Self‐Assembled Integrative Nutrient Carrier Platform Containing Green Tea Catechin for Short Bowel Syndrome Treatment
Authors: Zhou Zhengming , Li Ke , Shi Lei , Wang Yunfeng , He Yunxiang , Hu Wen , Guo Junling 
Published: November 2022

AbstractExtensive resection of the small intestine leads to the development of short bowel syndrome (SBS), which reduces the effective absorptive surface area of the intestine and predisposes patients to emaciation, malnutrition, and other severe symptoms. Herein, green tea catechin (−)‐epigallocatechin gallate (EGCG) and ferrous ions (Fe2+) are utilized to construct a nutrient carrier platform that self‐assembles with nutrients to form phenolic‐based nutrient complexes (PNCs). PNCs effectively prolong the residence and absorption time of nutrients in the intestine. Further this platform is applied to integrate full nutrient formula, an enteral nutrition (EN) preparation containing a range of full nutrient components. In an SBS rat model, the prepared phenolic‐based integrative nutrient complexes (PINCs) enhance nutritional status, improve anemia and immune function, as well as facilitate the growth of remaining intestinal villi and crypts, and maintain the integrity of the intestinal barrier. In addition, PINCs enable the modulation of gut microbial dysbiosis, enrich the abundance of beneficial bacteria, and have no toxic effects after the long‐term ingestion. These results provide a proof of principle for the use of polyphenol‐based nanocomplexes as EN preparation, offering a feasible strategy for both nutritional support and therapeutic perspectives for SBS treatment.
Janus Microdroplets with Tunable Self‐Recoverable and Switchable Reflective Structural Colors
Authors: Liu Mingzhu , Fu Jiemin , Yang Shengsong , Wang Yuchen , Jin Lishuai , Nah So Hee , Gao Yuchong , Ning Yifan , Murray Christopher B. , Yang Shu 
Published: November 2022

AbstractMicrodroplets made from chiral liquid crystals (CLCs) can display reflective structural colors. However, the small area of reflection and their isotropic shape limit their performance. Here, Janus microdroplets are synthesized through phase separation between CLCs and silicone oil. The as‐synthesized Janus microdroplets show primary structural colors with ≈14 times larger area compared to their spherical counterparts at a specific orientation; the orientation and thus the colored/transparent states can be switched by applying a magnetic field. The color of the Janus microdroplets can be tuned ranging from red to violet by varying the concentration of the chiral dopant in the CLC phase. Due to the density difference between the two phases, the Janus microdroplets prefer to orientate the silicone oil side up vertically, enabling the self‐recoverable structural color after distortion. The Janus microdroplets can be dispersed in aqueous media to track the configuration and speed of magnetic objects. They can also be patterned as multiplexed labels for data encryption. The magnetic field‐responsive Janus CLC microdroplets presented here offer new insights to generate and switch reflective colors with high color saturation. It also paves the way for broader applications of CLCs, including anti‐counterfeiting, data encryption, display, and untethered speed sensors.
Efficient Combination of Surface Texturing and Functional Coating for Very Low Secondary Electron Yield Surfaces and Rough Nonevaporable Getter Films
Authors: Himmerlich Marcel , Zanin Danilo A. , Taborelli Mauro , Granadeiro Costa Angelo Rafael , Costa Pinto Pedro , Lain Amador Lucia , Vollenberg Wilhelmus , Baris Adrienn , Garcia‐Tabares Valdivieso Elisa , Perez Fontenla Ana Teresa , Wackerow Stefan , Abdolvand Amin 
Published: November 2022

AbstractThe formation of a fissured copper surface by picosecond pulsed laser irradiation is combined with functional coatings consisting of Ti and amorphous carbon layers or a Ti–Zr–V compound film to fabricate surfaces with the maximum of the secondary electron yield being as low as 0.4. By structural and spectroscopic analysis of the formed surfaces it is demonstrated that both coatings enclose the nanostructures generated by redeposition of metal structures from the laser‐induced plasma plume, keeping the initial topography intact. This allows an efficient elimination of secondary electron emission by combining the benefits from structural surface modification and adaption of electronic surface properties to efficiently dissipate the energy of impinging electrons. Thermal activation tests of the Ti–Zr–V nonevaporable getter films revealed that for films on nanostructured substrates, which have a much higher effective surface, a slight diminution of surface activation occurs at 160 and 200 °C, while this effect is completely compensated when heating up to 250 °C indicating promising pumping capabilities. Both examples highlight the benefits from combining 3D substrate patterning with classical 2D deposition technologies.
Exosomes Derived from miR‐195‐5p Transfected Bone Marrow Mesenchymal Stem Cells Alleviate Pelvic Floor Dysfunction in Rats
Authors: Chen Ying , Wan Sheng , Zhou Chenchen , Gu Shengyi , Zhou Tianfan , Yao Liping , Pei Jindan , Hua Xiaolin 
Published: November 2022

AbstractBone marrow‐derived mesenchymal stem cells (BMSCs) can alleviate pelvic floor dysfunction (PFD) in rats. Whether exosomes derived from miR‐195‐5p transfected BMSCs can alleviate PFD is investigated. The rat vaginal distention model is constructed to mimic PFD. miR‐195‐5p is transfected into BMSCs, and exosomes derived from miR‐195‐5p transfected BMSCs are injected into PFD rats via caudal veins. Luciferase reporter assay is performed to confirm the direct interaction between SMAD7 3′‐UTR and miR‐195‐5p mimics. Void volume, bladder void pressure, leak point pressure, and peak bladder pressure are used to evaluate urodynamic function. It is found that miR‐195‐5p directly targets Smad7 and regulates the relative Smad7 expression in rat BMSCs. Exosomes derived from miR‐195‐5p transfected BMSCs can improve urodynamic function than exosomes derived from BMSCs. On the other hand, exosomes derived from miR‐195‐5p transfected BMSCs inhibit the expressions of Smad7 but promote the expressions of elastin in PFD rats with diminished expression of MMP2 and MMP9. This study demonstrates that exosomes derived from miR‐195‐5p genetically engineered BMSCs can target the Tgf‐β/Smad7 pathway to repair connective tissues and restore damaged urodynamic function in PFD rats.
Examining the influence of group diversity on the functioning of community‐based participatory research partnerships: A mixed methods study
Authors: Chandanabhumma P. Paul , Fàbregues Sergi , Oetzel John , Duran Bonnie , Ford Chandra 
Published: November 2022

AbstractPublic health has endorsed the use of community‐based participatory research (CBPR) to address health inequities involving diverse and marginalized communities. However, few studies have examined how group diversity among members of CBPR partnerships influenced how well the partnerships achieve their goals of addressing health inequities through equitable collaboration. We conducted secondary, convergent, mixed methods analysis to (1) evaluate the association between group diversity and participatory decision‐making within CBPR partnerships, and (2) identify the perceived characteristics, benefits, and challenges of group diversity within CBPR partnerships. Using data from a cross‐site study of federally funded CBPR partnerships, we analyzed and integrated data from surveys of 163 partnerships (n = 448 partners) and seven in‐depth case study interviews (n = 55 partners). Quantitatively, none of the measured characteristics of group diversity was associated with participatory decision‐making within the partnerships. Qualitatively, we found that partnerships mainly benefited from membership differences in functional characteristics (e.g., skillset) but faced challenges from membership differences in sociocultural characteristics (e.g., gender and race). The integrated findings suggest the need to further understand how emergent group characteristics and how practices that engage in group diversity contribute to collective functioning of the partnerships. Attention to this area can help promote health equity achievements of CBPR partnerships.
Water‐soluble Self‐assembled {Pd84}Ac Polyoxopalladate Nano‐wheel as a Supramolecular Host
Authors: Sinclair Zoë L. , Bell Nicola L. , Bame Jessica R. , Long De‐Liang , Cronin Leroy 
Published: November 2022

AbstractPolyoxopalladates (POPs) are a class of self‐assembling palladium‐oxide clusters that span a variety of sizes, shapes and compositions. The largest of this family, {Pd84}Ac, is constructed from 14 building units of {Pd6} and lined on the inner and outer torus by 28 acetate ligands. Due to its high water solubility, large hydrophobic cavity and distinct 1H NMR fingerprint {Pd84}Ac is an ideal molecule for exploring supramolecular behaviour with small organic molecules in aqueous media. Molecular visualisation studies highlighted potential binding sites between {Pd84}Ac and these species. Nuclear Magnetic Resonance (NMR) techniques, including 1H NMR, 1H Diffusion Ordered Spectroscopy (DOSY) and Nuclear Overhauser Spectroscopy (NOESY), were employed to study the supramolecular chemistry of this system. Here, we provide conclusive evidence that {Pd84}Ac forms a 1 : 7 host‐guest complex with benzyl viologen (BV2+) in aqueous solution.
Kombination von Deep Eutectic Solvents mit TEMPO‐basierten Polymerelektroden: Einfluss des Molaren Verhältnisses auf das Elektrodenverhalten**
Authors: Uhl Matthias , Geng Tanja , Schuster Philipp A. , Schick Benjamin W. , Kruck Matthias , Fuoss Alexander , Kuehne Alexander J. C. , Jacob Timo 
Published: November 2022

AbstractVollorganische Batterien auf Grundlage redoxaktiver Polymere versprechen eine Alternative zu Lithium‐Ionen‐Batterien für die nachhaltige Energiespeicherung zu werden. Polymere tragen bisher als Elektroden oder als feste Elektrolyte zum Ziel einer rein organischen Zelle bei. Hier ersetzen wir den Elektrolyten durch ein Deep Eutectic Solvent (DES), das aus Natriumbis(trifluormethansulfonyl)imid (NaTFSI) und N‐Methylacetamid (NMA) besteht, und verwenden Poly(2,2,6,6‐tetramethylpiperidin‐1‐yl‐oxylmethacrylat) (PTMA) als Kathode. Von der erfolgreichen Kombination eines DES mit einer Polymerelektrode wird hier zum ersten Mal berichtet. Die elektrochemische Stabilität von PTMA‐Elektroden im DES ist beim eutektischen Stoffmengenverhältnis von 1 : 6 mit herkömmlichen Batterieelektrolyten vergleichbar. Viskosere Elektrolyte mit höherer Salzkonzentration können das Zykeln bei hohen Raten behindern. Eine niedrigere Salzkonzentration führt zu sinkenden Kapazitäten und schnellerer Zersetzung. Die eutektische Mischung von 1 : 6 ist am besten geeignet, um hohe Stabilität und moderate Viskosität zu vereinen.