bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence of diabetes distress and its association with glycaemia in young people living with insulin‐requiring‐diabetes in a regional centre in Australia
Authors: Stapleton Ciara , Watkins Elizabeth , Hare Matthew J L , Timms Francesca , Wood Anna J , Titmuss Angela 
Published: October 2022

AimEmotional responses, such as feeling overwhelmed with diabetes‐related treatment, burnt‐out and anxiety, are known as ‘diabetes distress’. This study aimed to determine diabetes distress among children, adolescents and parents/carers managing insulin‐requiring diabetes in a regional Australian setting, and to assess association with glycaemia.MethodsAll children, adolescents and their parents/carers attending a regional hospital outpatient diabetes clinic between March 2018 and June 2019 were invited to complete a validated child, adolescent or parent/carer diabetes distress questionnaire. Demographics and time‐matched clinical data were obtained from hospital records. A cross‐sectional analysis was performed.ResultsA total of 43 young people and 30 parents/carers completed a diabetes distress questionnaire during the study period. Diabetes distress was common, with 63% of young people and 67% of parents/carers nominating at least one serious concern. After adjustment for potential confounding factors, higher glycaemia (HbA1c%) was associated with higher distress scores among both young people (ß 6.2, 95% confidence interval (CI): 3.2–9.2, P < 0.001) and carers/parents (ß 5.6, 95% CI:1.5–9.8, P < 0.001). Diabetes distress did not differ by child age, duration of diagnosis or mode of insulin administration. For children, adolescents and carers, ‘serious concerns’ most commonly related to the impact of diabetes upon family and peer relationships.ConclusionsDiabetes distress was common and associated with sub‐optimal glycaemia. Routine screening for diabetes distress should be considered in paediatric services. Development of strategies to minimise diabetes distress for youth and families is required.
Phenytoin induces connective tissue growth factor (CTGF/CCN2) production through NADPH oxidase 4‐mediated latent TGFβ1 activation in human gingiva fibroblasts: Suppression by curcumin
Authors: Deng Yi‐Ting , Wu King‐Jean , Kuo Mark Yen‐Ping 
Published: October 2022

AbstractObjective and BackgroundGingival overgrowth (GO) is a common side effect of some drugs such as anticonvulsants, immunosuppressant, and calcium channel blockers. Among them, the antiepileptic agent phenytoin is the most common agent related to this condition due to its high incidence. Transforming growth factor β (TGFβ) importantly contributes to the pathogenesis of GO. Connective tissue growth factor (CTGF or CCN2) is a key mediator of tissue fibrosis and is positively associated with the degree of fibrosis in GO. We previously showed that Src, c‐jun N‐terminal kinase, and Smad3 mediate TGFβ1‐induced CCN2 protein expression in human gingival fibroblasts (HGFs). This study investigates whether phenytoin can induce CCN2 synthesis through activated latent TGFβ in HGFs and its mechanisms.MethodsCCN2 synthesis, latent TGFβ1 activation, and cellular reactive oxygen species (ROS) generation in HGFs were studied using western blot analysis, a TGFβ1 Emax® ImmunoAssay System, and 2′,7′‐dichlorodihydrofluorescein diacetate (an oxidation‐sensitive fluorescent probe), respectively.ResultsPhenytoin significantly stimulated CCN2 synthesis, latent TGFβ1 activation, and ROS generation in HGFs. Addition of an TGFβ‐neutralizing antibody, TGFβ receptor kinase inhibitor SB431542, and Smad3 inhibitor SIS3 completely inhibited phenytoin‐induced CCN2 synthesis. General antioxidant N‐acetylcysteine, NADPH oxidase (NOX) inhibitor diphenylene iodonium, and specific NOX4 inhibitor plumbagin almost completely suppressed phenytoin‐induced total cellular ROS and latent TGFβ1 activation. Curcumin dose‐dependently decreased phenytoin‐induced TGFβ1 activation and CCN2 synthesis in HGFs.ConclusionsOur findings indicated that NOX4‐derived ROS play pivotal roles in phenytoin‐induced latent TGFβ1 activation. Molecular targeting the phenytoin/NOX4/ROS/TGFβ1 pathway may provide promising strategies for the prevention and treatment of GO. Curcumin‐inhibited phenytoin‐induced CCN2 synthesis is caused by the suppression of latent TGFβ1 activation.
Exosome‐associated microRNA‐375 induces cell proliferation by regulating IGFBP4 upon hepatitis C virus infection
Authors: Pradhan Aunji , Shivaprasad Shwetha , Dey Shuchismita , Goel Amit , Aggarwal Rakesh , Das Saumitra 
Published: October 2022

AbstractHepatitis C virus (HCV) infection is one of the most common causes of liver cancer. HCV infection causes chronic disease followed by cirrhosis, which often leads to hepatocellular carcinoma (HCC). In this study, we investigated the roles of exosome‐associated miRNAs in HCV‐induced disease pathology. Small RNA sequencing was performed to identify miRNAs that are differentially regulated in exosomes isolated from patient sera at two different stages of HCV infection: cirrhosis and hepatocellular carcinoma. Among the differentially expressed miRNAs, miR‐375 was found to be significantly upregulated in exosomes isolated from patients with cirrhosis and HCC. A similar upregulation was observed in intracellular and extracellular/exosomal levels of miR‐375 in HCV‐JFH1 infected Huh7.5 cells. The depletion of miR‐375 in infected cells inhibited HCV‐induced cell migration and proliferation, suggesting a supportive role for miR‐375 in HCV pathogenesis. miR‐375, secreted through exosomes derived from HCV‐infected cells, could also be transferred to naïve Huh7.5 cells, resulting in an increase in cell proliferation and migration in the recipient cells. Furthermore, we identified Insulin growth factor binding protein 4 (IGFBP4), a gene involved in cell growth and malignancy, as a novel target of miR‐375. Our results demonstrate the critical involvement of exosome‐associated miR‐375 in HCV‐induced disease progression.
Daily screen time, sleep pattern, and probable sleep bruxism in children: A cross‐sectional study
Authors: Amaral Cássia Cardozo , Fernandez Matheus dos Santos , Jansen Karen , da Silva Ricardo Azevedo , Boscato Noéli , Goettems Marília Leão 
Published: October 2022

AbstractObjectiveThis study aimed to evaluate the prevalence of probable sleep bruxism (SB) in children aged 7–8 years and its association with sleep pattern and the time spent using devices with a screen.Material and MethodsA cross‐sectional study was conducted with children from Pelotas, Brazil (n = 556). Parents/caregivers were interviewed and provided demographic/socioeconomic information, children's daily screen time, nighttime tooth grinding or clenching, sleep duration and answered the Biological Rhythms Interview for Assessment in Neuropsychiatry for Kids (BRIAN‐K‐sleep domain). Probable SB was determined based on a positive clinical inspection with/without a positive parental/caregiver's reports of tooth clenching or grinding. Hierarchical Poisson regression was performed.ResultsThe prevalence of probable SB was 15.83% (n = 88). There was no difference in the probable SB prevalence according to the daily screen time (p = 0.744), and low family socioeconomic status was associated with higher SB prevalence (Prevalence Ratio [PR] = 1.95; 95% Confidence Interval [95% CI]: 1.21–3.17; p = 0.006). Higher scores in the sleep domain of the BRIAN‐K scale were associated with probable SB [PR = 1.07; 95% CI: 1.01–1.30; p = 0.013].ConclusionsDifficulties in maintaining sleep and low family socioeconomic status were associated with probable SB in schoolchildren, while screen time spent using devices with a screen was not associated.
Selectivity of polyclonal repertoire of anti‐microbial IgA and its subclasses in saliva and serum in humans
Authors: Nikodijević Slavomir , Blagojević Veljko , Ćuruvija Ivana , Kosanović Dejana , Djukić Tamara , Djordjević Brižita , Ilić Vesna , Minić Rajna 
Published: October 2022

AbstractIncreased interest in microbiota calls for the thorough analysis of antibody reactivity to different microorganisms. As salivary IgA represents the first line of defence against microorganisms contacting mucosal surfaces, we explored the binding and specificity of salivary IgA by testing the binding of purified, FITC‐labelled salivary IgA to different microorganisms in flow cytometry and conclude that this kind of analysis enables the differentiation of species/strains with high IgA binding capacity, which should be corroborated on a larger sample size. Further we compare, with in‐house ELISA, the binding of polyclonal salivary IgA with the binding of polyclonal serum IgA from the same individuals to whole microbial cells and to purified microbial components. High correlations were obtained in total salivary IgA binding to Lactobacillus rhamnosus and Escherichia coli, very distant bacterial species, as well as to isolated bacterial components (r = .70–.97). The binding of total salivary IgA resembled the binding of both salivary IgA1 and IgA2, with IgA2 predominating. For serum polyclonal IgA repertoire, substantially higher specificity was obtained. Serum IgA binding to E. coli correlated best with serum IgA binding to lipopolysaccharide (r = .86), and serum IgA against L. rhamnosus correlated best with the anti‐peptidoglycan IgA levels (r = .88). We have also detected that total serum IgA response is governed by either IgA1 or IgA2 response, depending on the nature of the antigen/s. We conclude that steady state salivary IgA repertoire, unlike serum IgA repertoire, consists of polyreactive antibodies with innate specificity, questioning its capacity to select resident microbiota.
Housing affordability, market interventions, and policy platforms in the 2022 Ontario provincial election
Authors: Dantzler Prentiss A. ,   Urban Policy Collective
Published: October 2022

AbstractSince the Great Recession, many cities around the world have undergone extreme demographic changes as people and capital resettle into urban areas. This has resulted in issues of gentrification and displacement forcing many governments to address growing concerns of housing insecurity. Housing policy is a function of political ideologies and social conditions drawing from market‐based housing supply (MBHS) solutions or demand‐side interventions (DSI) to alleviate housing cost burdens. Yet, debates on their effectiveness have often undermined their ability to grow to scale leaving many households in precarious housing situations. This paper focuses on the 2022 Ontario provincial election to uncover how Canadian political parties frame housing insecurity and their policy platforms. This paper finds all political parties promote the MBHS framework, yet various degrees of the DSI framework. Embedded within this variation are questions of federalism with responsibility shifting between provincial and municipal governments. The findings reveal while different forms of neoliberal ideology inform the policy platforms of political parties, federalism plays a significant role in framing the level and scale of government involvement.
RESPONSE TO THE COMPATIBILITY OF EVOLUTION AND DESIGN
Authors: Sollereder Bethany N. 
Published: October 2022

AbstractThe first half of this article offers two possibilities of how the argument Kojonen makes might be vulnerable to other new developments in evolutionary science and psychology—potential broadsides that might threaten to sink the salvaged ship of design once again. Work on the development of life suggests that life is a simplification of surrounding environmental information, and therefore life does not generate new information. Second, the psychology of pareidolia suggests we find design as a bias of our information processing, rather than observing something that exists. The second half of the article offers a critique of how the metaphors we use to describe God and the world shape our approaches to solving theological and philosophical questions (particularly theodicy). I offer some organic metaphors in place of the usual mechanistic metaphors to think about how the design argument could be reformulated.
Characterization of Basin of Attraction for An Attractor in A Discrete Prey-Predator Sea Turtle-Human Interaction Model using Stability Index Approach
Authors: Mohd Lutfi Mohd Tirmizi , Mohd Roslan Ummu Atiqah , Ghane Fatemeh Helen , Embong Ahmad Fadillah 
Published: October 2022

Drastic declines of the number of sea turtles have become a global issue since decades ago. This is due to overexploitation through human activities in various ways, such as poaching and trapping in the fishing nets, consuming their eggs and meat, other than being threatened by pollution, habitat destruction and many more. Therefore, it is our interest to investigate this issue through mathematical modelling. For that purpose, a discrete model of interaction between sea turtles and humans is proposed in this paper. The objective of this paper is to determine sustainability of sea turtle population in the future. In order to achieve this, an approach called the stability index, has been implemented on the basin of attraction of an attractor in the model proposed for different values of consumption rate The results show that the stability indices vary from down to positive values as increases. Biologically, index means that the sea turtles will survive, while positive index means that riddled basin has occurred in which it is predicted that the sea turtles might extinct or not depending on the initial population existing in a habitat. Moreover, the time series have also been plotted for different values of The patterns show that for a low the sea turtles will survive in the next 10 years while when is high, the sea turtle will extinct in less than two years. Thus, the results of this model could significantly be used to urge humans to stop exploiting these unique creatures and start appreciating their existence in the ecosystem.
Experimental Investigation into Liquid and Solid Separation by an Industrial Mesh-Vane-Type Separator on Natural Gas at 4–5 MPa, Different Liquid Loadings and Gas Flows
Authors: Botros K.K. , Chan N. , Geerligs J. , Leong K. , Hickey B. , Gong I. 
Published: October 2022

AbstractInline vertical separators are commonly employed in natural gas transmission facilities (e.g., receipt stations) to filter liquid contaminants such as compressor oil, glycol, and free water from the gas stream. Manufacturers of these separators have claimed liquid removal efficiencies of 98–99% for droplet sizes ≥ 8 μm. However, these contaminants have been found invariably in piping systems downstream of these separators, suggesting inadequate separator performance. Currently, there is a lack of ability to verify manufacturer claims due to difficulties in quantifying liquid contaminants and droplet characteristics. The potential consequences of having such contaminants include lower gas quality, impaired gas metering accuracy, corrosion and damage to equipment/instrumentation, and adverse impacts on industrial and residential end users. This paper presents performance testing of a mesh-vane-type vertical separator conducted on high pressure, pipeline quality, natural gas in the range of 4–5 MPa and flow velocity in the range of 1.3–13 m/s in the DN150 separator inlet (hence turndown ratio of 10:1). Four different spray nozzles were used to inject and atomize industrial compressor oil with a liquid-to-gas mass loading ratio of 0.06–1.8%. Test results revealed that the average bulk efficiency separation performance for this separator is approximately 90.34%. This was found to be independent of the liquid-to-gas mass loading ratio. The effective Souders–Brown K-factor was found to be 0.15 m/s. This is below literature published data in the range of 0.27–0.3 m/s for horizontal flow, vane-pack-type separators. Liquid separation tests were also conducted following the injection of solid glass beads. Liquid separation efficiency decreased by approximately 9%, following the injection of 7 kg of industrial glass beads over a period of approximately 4 h. This was attributed to accumulation of solids in the vane pack.
A Data-Driven Proxy Modeling Approach Adapted to Well Placement Optimization Problem
Authors: Amiri Kolajoobi Rasool , Emami Niri Mohammad , Amini Shahram , Haghshenas Yousof 
Published: October 2022

Abstract
Well placement optimization (WPO) plays an essential role in field management and economy. However, it entails massive computational time and demand since hundreds, even thousands, simulation runs are needed. Different types of proxy models have been utilized to address this issue. Among different proxy models, data-driven proxies are preferred as they can determine the combined effect of several parameters without suffering from the type and the number of modeling parameters. This article aims to develop a data-driven proxy model in an artificial intelligence framework adapted to the WPO problem. This proxy estimates and compares the oil recovery for different well configurations. Our contribution is building a dynamic proxy by training a sequence of static proxies in a time-dependent manner to make more benefit from the modeling capability of artificial neural networks (ANNs). The workflow comprises preparing a learning database using experimental design techniques, finding the significant parameters by searching the parameter space, training and validating a series of ANNs to obtain the desired field response, and conducting a blind test to ensure the model performance and generality. This proxy is then coupled with the genetic algorithm to find an optimal well configuration in a test case. Verifying the results obtained by our proxy with those of a commercial simulator shows that the objectives of constructing this proxy for WPO are successfully achieved.
Screening of Medicinal Compounds in Blood by Atmospheric Pressure Laser Plasma Ionization Mass Spectrometry
Authors: Kravets K. Yu. , Timakova S. I. , Grechnikov A. A. , Borodkov A. S. , Laptinskaya P. K. , Kuzmin V. S. , Simanovsky Ya. O. 
Published: October 2022

Abstract
We proposed a procedure for screening drug compounds by high-resolution mass spectrometry with atmospheric pressure laser plasma ionization (APLPI). The analytical performance of the method was studied on examples of five medicinal compounds: Lidocaine, Bendazole, Papaverine, Chloropyramine, and Carbamazepine. Calibration dependences were obtained in the analysis of model solutions and blood samples; sensitivity coefficients were determined. The relative standard deviation of the results is in the range 20–27%. The APLPI technique can detect promptly and reliably the studied medicinal compounds at concentrations 0.5–6 ng/mL in a sample. The sensitivity of APLPI exceeds that of atmospheric pressure electrospray ionization by 4–16 times.
Importance of Delayed Reperfusions in Patients With Incomplete Thrombectomy
Authors: Mujanovic Adnan , Jungi Noel , Kurmann Christoph C. , Dobrocky Tomas , Meinel Thomas R. , Almiri William , Grunder Lorenz , Beyeler Morin , Lang Matthias F. , Jung Simon , Klail Tomas , Hoffmann Angelika , Seiffge David J. , Heldner Mirjam R. , Pilgram-Pastor Sara , Mordasini Pasquale , Arnold Marcel , Piechowiak Eike I. , Gralla Jan , Fischer Urs , Kaesmacher Johannes 
Published: October 2022

Background:
There is paucity of data regarding the effects of delayed reperfusion (DR) on clinical outcomes in patients with incomplete reperfusion following mechanical thrombectomy. We hypothesized that DR has a strong association with clinical outcome in patients with incomplete reperfusion after mechanical thrombectomy (expanded Thrombolysis in Cerebral Infarction, 2a–2c).

Methods:
Single-institution’s stroke registry retrospective analysis of patients admitted from February 2015 to December 2020. DR was defined as the absence of any perfusion delay on ≈24-hour contrast-enhanced follow-up perfusion imaging, whereas persistent perfusion deficit denotes a perfusion delay corresponding to the catheter angiographic deficit directly after the intervention. The association of perfusion outcome (DR versus persistent perfusion deficit) with the occurrence of new infarcts and 90-day functional independence (modified Rankin Scale score 0–2) was evaluated using logistic regression analyses. Comparison of predictive accuracy was evaluated by calculating area under the curve for models with and without perfusion outcome.

Results:

In 566 patients (mean age 74, 49.6% female), new infarcts in the incomplete reperfusion areas were less common in DR versus persistent perfusion deficit patients (small punctiform: 17.1% versus 25%, large confluent: 7.9% versus 63.2%;
P
=0.001). After adjustment for confounders, DR was a strong predictor of functional independence (adjusted odds ratio, 2.37 [95% CI 1.34–4.23]). There was a significant improvement in predictive accuracy of functional independence when perfusion outcome was added to expanded Thrombolysis in Cerebral Infarction alone (area under the curve 0.57 versus 0.62,
P
=0.01).

Conclusions:
Occurrence of DR is closely associated with tissue outcome and functional independence. DR may be an independent prognostic parameter, suggesting it as a potential outcome surrogate for medical rescue therapies.
La maison du diacre Fatḥī
Authors: Fathi Jean 
Published: October 2022

Résumé
Aux XVIIIe et XIXe siècles, la maison du diacre Amīršāh Fatḥī de Diyarbakır se trouvait à l’épicentre des événements concernant la communauté ancienne-syrienne d’héritage syriaque dans l’Empire ottoman, ayant un mot à dire dans l’élection des patriarches à Mardin et les tentatives d’union entre l’Église syrienne-orthodoxe d’Antioche et l’Église catholique. Les Cogias Fatḥī dérivaient leur autorité des moyens générés par leur maison de négoce, qui participait dans les années 1700 au commerce international entre la Perse, les territoires ottomans et l’Europe. Leur histoire est contée à partir d’une vingtaine d’archives en Orient et Occident.
Qannūbīn Monastery and the Religious Soundscape of the Maronites in the 16th and 17th Century
Authors: Rodriguez Suarez Alex 
Published: October 2022

Abstract
This article discusses the religious soundscape of the Maronites in the 16th and the 17th century as reflected in Western travel accounts that report the use of church bells at Qannūbīn Monastery in Lebanon, the residence of the Maronite patriarch. Bell ringing for religious purposes was actually forbidden in the Ottoman Empire. The Christian communities of the Levant employed a wooden instrument, the semantron, to call the faithful to service. Qannūbīn was an exception. Information provided by pilgrims and travelers sheds light on some of the reasons behind the use of bell ringing in this remote religious foundation. Moreover, I argue that the use of bells at Qannūbīn was related to the close contacts between the Maronite clergy and the Pope of Rome. The former wanted to be in communion with the Roman Church. The use of bell ringing at the patriarchal residence assisted to project a Catholic image by means of sound.
Προοικονομία in Melito
Authors: Clarke Kevin M. 
Published: October 2022

Abstract
Melito’s presupposition that Israel should have been able to recognize the Christ has drawn him much criticism. This essay explores the identity of Melito’s Israel and the rhetorical trope that Melito employs: censure of Israel. Melito’s understanding of the continuity between the “old” and “new” remains underexplored in the significance of its claim. Melito has a profound insight in his interpretative key for the relationship of the old covenant with respect to the new, namely that God made prior arrangements (προοικονοµία) for Christ’s sufferings in the Old Testament. Finally, the essay will examine Melito’s οἰκονοµία. In short, the προοικονοµία provides an early Christian account to describe the manner in which the mysteries of the life of Christ (οἰκονοµία) could be hidden beforehand (προ-) by God in the life and history of the people of Israel and made manifest in the Easter celebration. Melito therefore develops a truly mystagogical exegesis.