bluuebunny/crossref_metadata_2025_split huggingface dataset:
The long-term impact of coaching in an executive MBA program
Authors: Fulmore Julia A. , Olson Jude , LaCoste Linda 
Published: September 2022

Purpose
The purpose of this qualitative study is to conduct an exploratory investigation of the impact and sustainability of coaching on career and leadership development of students and later, alumni, in an Executive Master of Business Administration (EMBA) program.

Design/methodology/approach
The sample for this qualitative study consisted of 14 alumni of an EMBA program at a private university in the Southwestern US who graduated between January 2012 and May 2019. Eleven alumni participated in the focus groups, and three alumni participated in personal interviews.

Findings
The open coding of the data resulted in three emergent themes (personal development by overcoming personal deficiencies, coaching translates to learning about leadership and coaching motivates sustained change) that confirmed the positive long-term effect of coaching as part of an EMBA program.

Practical implications
By participating in an executive coaching engagement, the EMBA students learned a development process that they could repeat for themselves after graduation and transfer to others. In addition, the EMBA students were able to leverage knowledge gained from the coaching experience for the development of others.

Originality/value
While the positive impacts of coaching are well-documented, its long-term impact on EMBA students/alumni has not yet been studied. This study builds on other evaluative studies to identify the benefits of executive coaching.
An empirical analysis of facilitators and barriers to the hybrid work model: a cross-cultural and multi-theoretical approach
Authors: Sampat Brinda , Raj Sahil , Behl Abhishek , Schöbel Sofia 
Published: September 2022

PurposeThis paper examines the influence of facilitators and barriers on employees’ preference to work in a hybrid model. The study uses the theoretical lens of stimulus-organism-response (SOR) and dual factor theory (DFT). It examines the influence of health consciousness (stimulus), facilitators (e.g. work flexibility, work–life balance and team building) (organism) and barriers (e.g. pandemic and travel stressor and role overload [organism] on employees’ preference to work in a hybrid model) (response). Further, it tests the moderating influence of organizational culture.Design/methodology/approachA questionnaire survey was conducted among employees in India, Sri Lanka and Germany, obtaining 281 usable questionnaires. Structural equation modeling (SEM) using Warp PLS 7.0 was used as the analytical technique to examine the model fit and test hypotheses.FindingsThe findings reveal that health consciousness is essential in enhancing facilitators and motivating employees to prefer a hybrid working model. The study’s findings also prove the positive influence of work flexibility, work–life balance and team building as facilitators. The results suggest that pandemic and travel stressors inhibit employees’ preference for working in a hybrid model.Research limitations/implicationsThe study is based on a cross-sectional research design to generalise the findings. Future researchers can utilize longitudinal design to decipher the variation in response over time. The study has developed a model combining SOR with DFT; the authors suggest that future researchers use other theories in combination with SOR, like self-determination theory (SDT), to decipher the influence of intrinsic and extrinsic motivation of employees in the context of the hybrid working model.Practical implicationsThis study identifies the need for open communication with the employees to overcome their concerns regarding the hybrid working model. The study also suggests that human resource (HR) managers need to prioritize the task that needs to be accomplished from the office versus working from home. The authors recommend various measures, like water cooler breaks and a buddy system, to motivate employees to work in a hybrid model.Originality/valueThis study is among the first studies focused on the hybrid working model. The current study adds to the limited literature on the facilitators and barriers of working in a hybrid work model.
Mismeasurement and efficiency estimates: Evidence from smallholder survey data in Africa
Authors: Abay Kibrom A. , Wossen Tesfamicheal , Chamberlin Jordan 
Published: September 2022

AbstractSmallholder agriculture in sub‐Saharan Africa is commonly characterised by high levels of technical inefficiency. However, much of this characterisation relies on self‐reported input and production data, which are prone to systematic measurement error. We show theoretically that non‐classical measurement error introduces multiple identification challenges and sources of bias in estimating smallholders' technical inefficiency. We then empirically examine the implications of measurement error for the estimation of technical inefficiency using smallholder farm survey data from Ethiopia, Malawi, Nigeria and Tanzania. We find that measurement error in agricultural input and production data leads to a substantial upward bias in technical inefficiency estimates (by up to 85% for some farmers). Our results suggest that existing estimates of technical efficiency in sub‐Saharan Africa may be severe underestimates of smallholders' actual efficiency and what is commonly attributed to farmer inefficiency may be an artefact of mismeasurement in agricultural data. Our results raise questions about the received wisdom on African smallholders' production efficiency and prior estimates of the productivity of agricultural inputs. Improving the measurement of agricultural data can improve our understanding of smallholders' production efficiencies and improve the targeting of productivity‐enhancing technologies.
Lung adenocarcinoma coexisting with diffuse idiopathic pulmonary neuroendocrine cell hyperplasia manifesting as multiple pulmonary nodules: A case report
Authors: Inomata Sho , Matsumura Yuki , Kobayashi Yasuyuki , Yamaguchi Hikaru , Watanabe Masayuki , Ozaki Yuki , Muto Satoshi , Okabe Naoyuki , Shio Yutaka , Suzuki Hiroyuki 
Published: September 2022

AbstractDiffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH), a rare condition, is characterized by pathological proliferation of neuroendocrine cells. Some of them are localized to the airway mucosa, and others locally infiltrate to form tumorlets and nodules. Here, we present a patient with lung adenocarcinoma accompanied by DIPNECH, making the latter difficult to distinguish from multiple pulmonary metastases. The patient, a 72‐year‐old Japanese woman, was diagnosed as having stage IVA lung adenocarcinoma because she had multiple nodules in both lungs. Mutation of epidermal growth factor receptor gene having been found in the primary tumor, treatment with osimertinib was started. This resulted in shrinkage of the primary tumor, but not the multiple pulmonary nodules. To determine whether these lung nodules were indeed lung metastases, we performed right upper lobectomy with lymphadenectomy and wedge resection of the right lower lobe. On pathological examination, the primary tumor was diagnosed as invasive adenocarcinoma, whereas the multiple pulmonary nodules were diagnosed as DIPNECH manifesting as tumorlets. Therefore, the final diagnosis was stage IA1 lung adenocarcinoma accompanied by DINPECH. The patient had no recurrences 1 year after the operation without any additional treatment. This is a rare case of lung adenocarcinoma accompanied by DIPNECH presenting as multiple pulmonary nodules. DIPNECH should be included in the differential diagnosis of multiple pulmonary nodules.
Dysfunctional regulation of pivotal and key inflammatory pathways in infertile Indian women with genital tuberculosis
Authors: Parikh Firuza R. , Panpalia Madhavi , Mehta Trupti , Agarwal Sapna , Khandeparker Meenal , Chettiar Shiva Shankaran , Patel Alpesh , Jhala Devendrasinh D. , Chettiar Venkatlaxmi , Parikh Swapneil 
Published: September 2022

AbstractProblemDiagnosis of female genital tuberculosis (FGTB) remains elusive due to the paucibacillary nature of the disease. We evaluated if analysis of inflammatory pathways of endometrial tissue could establish a better diagnosis of FGTB.Method of StudyOne hundred and four infertile women suspected of having GTB or having been treated for GTB in the past, underwent endometrial biopsies for diagnosis and Gene Inflammatory Pathways analysis at our center between 2018–2020. Diagnosis of FGTB was based on acid‐fast bacilli culture, immunocytochemistry, nested‐polymerase chain reaction, histopathological examination, TB GeneXpert, or combinations thereof. Gene expression profiles were also analyzed.ResultsBased on diagnostic tests of 104 women, 44 (42%) were considered TB‐positive, 35 (34%) TB‐negative, and 25 (24%) TB‐negative after TB treatment in the past. Inflammatory pathways were significantly upregulated in TB‐positive women versus TB‐negative (41% vs. 6%; p = .0005), and in women who were TB‐negative after TB treatment in the past versus TB‐negative (never treated for TB in the past) (38% vs. 6%; p = .0037). Two‐hundred seventy‐one genes were upregulated, and 61 genes were downregulated in TB‐positive women versus those who were TB‐negative. Differentially expressed genes were mapped to various interlinked inflammatory signaling pathways, including mitogen‐activated protein kinase (MAPK), Natural Killer (NK) cells, nuclear factor kappa‐B (NF‐kB), tumor necrosis factor (TNF), and Toll‐like receptors (TLR) signaling.ConclusionsInflammatory pathways and gene expression profiles add to the diagnostic tools to identify TB‐positive women at an early stage. The results from this study are still experimental and large multi‐centric studies are suggested before their recommendation in routine clinical practice.
Prostaglandin E receptor 2 mediates the inducible effects of prostaglandin E2 on expression of growth factors and enzymes in cattle endometrial epithelial cells and explants
Authors: Zhang Shuangyi , Li Qianru , Mao Wei , Zhao Jiamin , Gong Zhiguo , Liu Bo , Cao Jinshan 
Published: September 2022

AbstractProstaglandin E2 (PGE2) is able to induce the expression of several growth factors and enzymes in cattle endometria. However, the specific type of PGE2 receptors which mediates this effect is not fully clear. In this study, the role of prostaglandin E receptor 2 (PTGER2) in PGE2‐mediated induction of growth factors and enzymes expression in cattle endometrial explants and epithelial cells were investigated. PTGER2 was blocked by a PTGER2 antagonist, AH6809, before PGE2 treatment, then the mRNA and protein expression levels of several growth factors and enzymes were compared with that in PGE2 alone treatment group by real‐time RT‐PCR and Western blotting analysis in endometrial epithelial cells and explants. Results indicated that PGE2 significantly increased the mRNA and protein levels of these growth factors and enzymes, while the rates of increment in the expression of these growth factors and enzymes were inhibited by AH6809. In addition, a PTGER2 agonist, butaprost, significantly increased the expression levels of these growth factors and enzymes, and the effect could be blocked by AH6809. In conclusion, PTGER2 was found to be one dominant receptor mediating the inducible effects of PGE2 on the expression of these growth factors and enzymes in cattle endometrial explants and epithelial cells.
The theoretical and practical arguments against the unilateral withdrawal of life‐sustaining treatment during crisis standards of care: Does the Knobe effect apply to unilateral withdrawal?
Authors: Maldonado Fabien , Gill Michael B. 
Published: September 2022

AbstractSome argue that it is ethically justifiable to unilaterally withdraw life‐sustaining treatment during crisis standards of care without the patient's consent in order to reallocate it to another patient with a better chance of survival. This justification has been supported by two lines of argument: the equivalence thesis and the rule of the double effect. We argue that there are theoretical issues with the first and practical ones with the second, as supported by an experiment aimed at exploring whether the Knobe effect, which affects the folk concept of intention, applies to situations of unilateral withdrawal. Fifty‐two critical care physicians from one university were asked to ascribe intention in two hypothetical scenarios A and B in which outcomes differ—the patient from whom life‐sustaining treatment is withdrawn dies in scenario A but survives in scenario B—but the intention, to save the other patient regardless of the outcome of the other, is the same. The survey was administered via a web‐based survey and all answers were anonymous. A paired proportion test was used to compare responses to both questions. All 52 surveyed individuals responded in scenario A and 30 (57.7%) ascribed intention when outcomes were unfavorable, whereas 50 responded in scenario B and 8 (16%) ascribed intention when outcomes were favorable, a difference that was statistically significant (p < 0.001). There are theoretical and practical issues with the arguments proposed to justify the unilateral withdrawal of life‐sustaining treatment based on the equivalence thesis and the rule of double effect.
Change-Plane Analysis for Subgroup Detection with a Continuous Treatment
Authors: Jin Peng , Lu Wenbin , Chen Yu , Liu Mengling 
Published: September 2022

Abstract
Detecting and characterizing subgroups with differential effects of a binary treatment has been widely studied and led to improvements in patient outcomes and population risk management. Under the setting of a continuous treatment, however, such investigations remain scarce. We propose a semiparametric change-plane model and consequently a doubly robust test statistic for assessing the existence of two subgroups with differential treatment effects under a continuous treatment. The proposed testing procedure is valid when either the baseline function for the covariate effects or the generalized propensity score function for the continuous treatment is correctly specified. The asymptotic distributions of the test statistic under the null and local alternative hypotheses are established. When the null hypothesis of no subgroup is rejected, the change-plane parameters that define the subgroups can be estimated. This paper provides a unified framework of the change-plane method to handle various types of outcomes, including the exponential family of distributions and time-to-event outcomes. Additional extensions with nonparametric estimation approaches are also provided. We evaluate the performance of our proposed methods through extensive simulation studies under various scenarios. An application to the Health Effects of Arsenic Longitudinal Study with a continuous environmental exposure of arsenic is presented.
Role of T CD4+ cells, macrophages, C‐low threshold mechanoreceptors and spinal Cav3.2 channels in inflammation and related pain‐like symptoms in murine inflammatory models
Authors: Picard Elodie , Kerckhove Nicolas , François Amaury , Boudieu Ludivine , Billard Elisabeth , Carvalho Frédéric Antonio , Bogard Gemma , Gosset Philippe , Bourdier Justine , Aissouni Youssef , Bourinet Emmanuel , Eschalier Alain , Daulhac Laurence , Mallet Christophe 
Published: September 2022

Background and PurposeT‐type calcium channels, mainly the Cav3.2 subtype, are important contributors to the nociceptive signalling pathway. We investigated their involvement in inflammation and related pain‐like symptoms.Experimental ApproachThe involvement of Cav3.2 and T‐type channels was investigated using genetic and pharmacological inhibition to assess mechanical allodynia/hyperalgesia and oedema development in two murine inflammatory pain models. The location of Cav3.2 channels involved in pain‐like symptoms was studied in mice with Cav3.2 knocked out in C‐low threshold mechanoreceptors (C‐LTMR) and the use of ABT‐639, a peripherally restricted T‐type channel inhibitor. The anti‐oedema effect of Cav3.2 channel inhibition was investigated in chimeric mice with immune cells deleted for Cav3.2. Lymphocytes and macrophages from either green fluorescent protein‐targeted Cav3.2 or KO mice were used to determine the expression of Cav3.2 protein and the functional status of the cells.Key ResultsCav3.2 channels contributed to the development of pain‐like symptoms and oedema in the two murine inflammatory pain models. Our results provided evidence of the involvement of Cav3.2 channels located on C‐LTMRs and spinal cord in inflammatory pain. Cav3.2 channels located in T cells and macrophages contribute to the inflammatory process.Conclusion and ImplicationsCav3.2 channels play crucial roles in inflammation and related pain, implying that targeting of Cav3.2 channels with pharmacological agents could be an attractive and readily evaluable strategy in clinical trials, to relieve chronic inflammatory pain in patients.
Common strategies in empirically supported psychological interventions for alcohol use disorders: A meta‐review
Authors: Nadkarni Abhijit , Massazza Alessandro , Guda Rahul , Fernandes Luanna T. , Garg Ankur , Jolly Mehak , Andersen Lena S. , Bhatia Urvita , Bogdanov Sergiy , Roberts Bayard , Tol Wietse A. , Velleman Richard , Moore Quincy , Fuhr Daniela 
Published: September 2022

AbstractIssuesDespite the large number of effective psychological interventions for alcohol use disorders (AUD), there is still a lack of clarity concerning the strategies that make these interventions effective.ApproachThe overall goal of this review was to identify, examine and synthesise the information about common strategies from evidence‐based psychological interventions for AUDs by conducting a review of systematic reviews, that is, a meta‐review. We isolated the relevant primary studies from eligible systematic reviews and extracted information about the interventions from these studies to understand the strategies used. Analysis was restricted to narrative summaries.Key FindingsThirteen reviews were eligible for inclusion in our meta‐review. Of these, eight demonstrated the effectiveness of a range of psychological interventions—behavioural couples therapy, cognitive behaviour therapy combined with motivational interviewing, brief interventions, contingency management, psychotherapy plus brief interventions, Alcoholics Anonymous and 12‐step treatment programs, family‐therapy or family‐involved treatment, and community reinforcement approach. The most commonly used component strategies in effective interventions for AUDs included assessment, personalised feedback, motivational interviewing, goal setting, setting and review of homework, problem solving skills and relapse prevention/management.ImplicationsEvidence about commonly used strategies in evidence‐based psychological interventions for AUDs offer the possibility of creating menu‐driven interventions that can be tailored to respond to individual client needs and preferences in different contexts.
Value premium and macroeconomic variables
Authors: Beccalli Elena , Doninelli Nicola , Orsini Cesare 
Published: September 2022

AbstractThis paper investigates the effect of macroeconomic expectations on the value premium. We introduce a two‐pass estimation procedure to extrapolate the impact of investors' macroexpectations on the firm fundamental value of Rhodes‐Kropf, Robinson, and Viswanathan. We find that the level and slope of the term structure affect valuation, revealing a heavily industry‐dependent effect. The portfolios sorted on metrics orthogonal to macroeconomic variables show a clear association between the misvaluation component of value premium and size risk. By removing the influence of the macroeconomic conditions and size, we separate the portion of the value premium that rewards macroeconomic expectations.
Elevated levels of sCD48 are inversely correlated with markers of disease activity in bullous pemphigoid
Authors: Treco Emma , Huan Eunice , Varzavand Afshin , Fairley Janet A. , Messingham Kelly N. 
Published: September 2022

AbstractsCD48 is elevated in diseases characterized by IgE and eosinophilia. Thus, serum levels sCD48 were evaluated in relation to clinical characteristics of Bullous pemphigoid (BP) patients. sCD48 levels were determined by ELISA in sera from 26 patients with classic BP and 26 healthy controls. Disease severity scores, differential blood counts, and circulating autoantibody levels were obtained. A correlation analysis was performed to establish relationships between sCD48 and clinical and laboratory markers of disease severity. Overall, circulating levels of sCD48 were significantly elevated in BP patients; however, when stratified based on disease severity, patients with mild–moderate disease had higher levels of sCD48 than those with severe disease. A Spearman's correlation analysis identified an inverse relationship between sCD48 and disease activity, serum BP180 IgE and peripheral eosinophil numbers. Further studies are needed to determine the pathologic relevance of these findings.
Preservice Spanish teachers analyze a nonexemplary lesson: Critical reflection in teacher preparation
Authors: Edstrom Anne 
Published: September 2022

The ChallengePreservice teachers' personal experiences as learners often shape their pedagogical beliefs. (1) How do preservice teachers evaluate a lesson that does not reflect best practices (as described by the World‐Readiness Standards) at the beginning and at the end of a methods course? (2) How do they describe changes in their perceptions?
Oxidative stability and in vitro release behaviour of microencapsulated Antarctic krill oil and fish oil: the effect of lipid class composition
Authors: Fu Jing‐jing , Fu Dong‐wen , Zhang Guang‐yao , Zhang Zhi‐hui , Shao Zhen‐wen , Ma Zhen‐hua , Tang Yue , Zhou Da‐yong , Song Liang 
Published: September 2022

SummaryAntarctic krill oil (AKO) and fish oil (FO) were microencapsulated by a pilot‐scale spray dryer in this study. The effect of lipid class compositions on the encapsulation properties of the obtained microcapsules was investigated. The particle size distribution of both microcapsules ranged from 29.23 ± 2.20 to 36.79 ± 3.45 μm, and the moisture content and water activity (aw) also indicated that both AKO and FO microcapsules were suitable for long‐term storage. Interestingly, differences in lipid composition affected the microstructure of the microcapsules formed, thereby affecting their oxidative stability and digestive behaviour. Compared with FO microcapsules, the surface microstructure of PLs‐enriched microcapsules (AKO microcapsules) was smoother, endowing it better oxidative stability and higher DHA (72.13 ± 2.32% vs. 63.08 ± 2.98%) and EPA (75.94 ± 1.43% vs. 68.26 ± 2.98%) bioaccessibility. These findings may have important implications for the development of microcapsules formulated with different lipid classes in the food industry.