bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral side effects of locally delivered nicotine replacement therapy: A meta‐analysis of randomized controlled trials
Authors: Sivaramakrishnan Gowri , Alsobaiei Muneera , Sridharan Kannan 
Published: April 2022

AbstractBackgroundNicotine replacement therapy is the first choice pharmacotherapy for smoking cessation. Oral side effects caused due to NRT lead to discontinuation of treatment. The objective of this meta‐analysis was to look for the certainty of evidence on the number of patients that reported oral side effects due to the use of NRT.MethodEligible studies were selected and data extraction was carried out independently into a pre‐tested data extraction form. Risk of bias was assessed using Cochrane Tool. The heterogeneity between the studies was assessed using Chi‐square and I2 tests. Mean difference and Odds ratio at 95% confidence interval were the effect estimates. GRADE working group approach was used to assess the quality of evidence.ResultsTwenty‐eight studies were included with moderate to low risk of bias. The pooled estimates revealed a statistically significant number of patients developed mouth or throat irritation (2.54 [1.23, 5.25]), or oral soreness (2.22 [1.40, 3.55]) or gastric reflux or vomiting (1.97 [1.34, 2.90]) due to NRT.ConclusionIt is important to understand that significant implications are caused due to NRT, on oral health. All patients on NRT must adhere to their regular dentist visits and must check their oral mucosa before initiating NRT.
Woringer‐Koloppdisease (localized pagetoid reticulosis): a systematic review
Authors: Osto Muhammad , Afify Omar , Musa Arif , Ahmed Uddin , Rehman Rafey , Mehregan Darius 
Published: April 2022

AbstractObjectiveWoringer‐Kolopp disease (WKD), also known as localized pagetoid reticulosis, is a rare variant of mycosis fungoides as described by the World Health Organization‐European Organization for Research and Treatment of Cancer (WHO‐EORTC) classification system for cutaneous lymphomas. Our objective was to conduct a comprehensive review that describes and evaluates patient demographics, clinical presentation, immunohistochemical findings, management, and outcomes of WKD.MethodsThe databases PubMed, Embase, and Cochrane Library were searched for relevant literature. Patient demographics, imaging, treatments, and other clinical characteristics were obtained. The literature search was conducted on December 7, 2020. Studies were included if they contained primary data related to WKD. Non‐pertinent studies, non‐English studies, non‐human studies, review articles, or studies with insufficient case information were excluded. The quality of the included studies and the risk of bias were evaluated using the Grades of Recommendation, Assessment, Development, and Evaluation Group (GRADE) criteria (2016), Oxford Centre for Evidence‐Based Medicine: Levels of Evidence (OCEBM) (March 2009), and the Methodological Index for Non‐Randomized Studies (MINORS) criteria (2003).ResultsA total of 84 studies with 143 patients met the inclusion criteria for this study. The most common chief complaint was an asymptomatic, slow‐growing, and erythematous plaque. The average time from initial skin eruption to presentation was 97.6 months. Histologically, 128 cases of WKD displayed epidermotropism (97.7%). Various therapies, including radiotherapy, surgery, and local chemotherapy, were used. In total, 92 (78.6%) cases had complete remission and 11 (9.4%) cases recurred.ConclusionsWKD is a rare cutaneous T‐cell lymphoma that often presents as a single plaque on the extremities with an indolent course and a favorable prognosis. However, it is often misdiagnosed, leading to delays in treatment. The diagnosis of WKD involves clinical appraisal, a biopsy of suspicious lesions, and immunohistochemistry. Monotherapy appears to be preferred compared to combination therapy for WKD with radiotherapy demonstrating among the highest cure rates and lowest recurrence. Future retrospective and prospective studies are needed to accurately determine the epidemiology, prognosis, and effective treatments for WKD. Limitations include a possibility of missed studies, heterogeneity in reporting methods, publication, and selection bias.
Comorbid diseases of hidradenitis suppurativa: a 15‐year population‐based study in Olmsted County, Minnesota, USA
Authors: Sokumbi Olayemi , Hodge David O. , Ederaine Sophia A. , Alavi Afsaneh , Alikhan Ali 
Published: April 2022

AbstractBackgroundLike other chronic, inflammatory skin disorders, hidradenitis suppurativa (HS) is increasingly recognized to be associated with various medical disorders.ObjectiveUsing the Rochester Epidemiology Project (REP), we sought to conduct the first American population‐based study examining the association between HS and various comorbid conditions.MethodsFrom the REP database, we identified patients diagnosed with HS from 2003 through 2018 who were residents of Olmsted County, Minnesota, USA, along with age‐ and gender‐matched controls. The frequency of a wide variety of comorbid conditions was compared between the groups.ResultsA total of 1160 patients with HS were identified during the study period. Compared with age‐ and gender‐matched controls, patients with HS had a significantly higher frequency of several medical conditions, including depression, anxiety, hyperlipidemia, acne conglobata, dissecting cellulitis, pilonidal cysts, polycystic ovary syndrome, diabetes, chronic kidney disease, psoriasis, atopic dermatitis, obesity, and disordered substance use, among others.LimitationsOur study was limited by its retrospective design.ConclusionsProviders caring for patients with HS should consider these results, along with those of similar studies, and obtain a thorough history, comprehensive physical examination, and, potentially, laboratory testing and referral to other specialists.
Early childhood caries sequelae and relapse rates in an Australian public dental hospital
Authors: Tsai Carrie , Li Ang , Brown Sophie , Deveridge Caitlin , El Gana Rania , Kucera Alice , Irving Michelle , Kumar Harleen 
Published: April 2022

AbstractBackgroundEarly childhood caries (ECC) remains one of the most prevalent childhood diseases in Australia, disproportionately affecting disadvantaged populations.AimTo investigate the ECC experience including risk factors, incidence of caries, pain and infection as well as relapse rates of caries and secondary dental general anaesthesia (GA).DesignA retrospective cohort study included dental records of children with ECC, aged <72 months at an Australian public dental hospital paediatric dentistry department from 2013 to 2015 (n = 102). Dental caries, pain, infection, referral patterns, demographic and caries risk factor data were recorded for 24 months. Descriptive statistics were used for patient characteristics and clinical data, and Kaplan–Meier curves and parametric exponential survival models for time‐to‐event series.ResultsThe study population demonstrated higher‐than‐national average dmft and disease progression at baseline. Major risk factors for the development of caries, pain and infection were daily consumption of sweetened beverages, poor oral hygiene, residing in lower socio‐economic areas, older age and being male. Rates of caries relapse and new referral for secondary treatment under general anaesthesia were relatively high.ConclusionA high degree of ECC progression and recurrence in this population indicates a need for a more comprehensive approach to ECC addressing multilevel root causes and systemic risk factors.
Clinical and socioeconomic burden of rhinoviruses/enteroviruses in the community
Authors: Halabi Katia Camille , Stockwell Melissa S. , Alba Luis , Vargas Celibell , Reed Carrie , Saiman Lisa ,   The Mobile Surveillance for Acute Respiratory Infection/Influenza‐like Illness in the Community (MoSAIC) Study Team
Published: April 2022

AbstractBackgroundThe epidemiology, clinical features, and socioeconomic burden associated with detection of rhinoviruses (RV)/enteroviruses (EV) from individuals in the community with acute respiratory infections (ARIs) are not fully understood.MethodsTo assess the clinical and socioeconomic burden associated with RV/EV, a secondary analysis of data collected during a prospective, community‐based ARI surveillance study was performed. From December 2012 to September 2017, adult and pediatric participants with ARIs had nasopharyngeal specimens obtained and tested by multiplex polymerase chain reaction assay. Characteristics and socioeconomic burden including missed school or work and/or antibiotic use among participants who did and did not seek medical care and among participants with and without co‐detection of another respiratory pathogen with RV/EV were compared.ResultsThroughout the study period, RV/EV was detected in 54.7% (885/1617) of ARIs with a respiratory pathogen detected. Most ARI episodes associated with RV/EV occurred in females (59.1%) and children ≤17 years old (64.2%). Those ≤17 years were more likely to seek medical care. Compared to those not seeking medical care (n = 686), those seeking medical care (n = 199) had a longer duration of illness (5 vs. 7 days) and were more likely to miss work/school (16.4% vs. 47.7%) and/or use antibiotics (3.6% vs. 34.2%). Co‐detection occurred in 8% of ARIs of which 81% occurred in children. Co‐detection was not associated with longer illness, more missed work/or school, or antibiotic use.ConclusionNon‐medically attended and medically attended ARIs associated with RV/EV resulted in clinical and socioeconomic burden, regardless of co‐detection of other respiratory pathogens.
Should I “check my emotions at the door” or express how I feel? Role of emotion regulation versus expression of male leaders speaking out against sexism in the workplace
Authors: Warren Meg A. , Sekhon Tejvir , Winkelman Katie M. , Waldrop Rachael J. 
Published: April 2022

AbstractAs witnesses to workplace sexism, male leaders have the opportunity to leverage both their relative social privilege as men and authority as leaders to enact allyship. However, allyship is fraught. Expression of indignation may be viewed by observers as unprofessional, yet a muted response may lead observers to question their motives for allyship. Further, allyship that does not hit the mark may have a ripple effect on observers' perceptions of the leader‐ally, victim, transgressor, and organization. Thus, the present research (1) examined whether emotion expression during allyship influences observers' motive inferences of the leader‐ally, (2) examined whether emotion expression influences favorability of the leader‐ally, and (3) explored how a leader‐ally's emotional (or not) allyship behavior influences observers' perceptions of the victim, transgressor, and organization. Study 1 (n = 298) showed that prejudice confrontation accompanied by anger or sadness (vs. not) is associated with intrinsic motive inferences of the leader‐ally, and anger is seen as more appropriate and sincere when confronting prejudice. Study 2 (n = 112) showed that the leader‐ally was viewed as more favorable when prejudice confrontation was accompanied by anger (vs. not) because the leader‐ally was perceived as more sincere. Finally, qualitative data from thought‐listings across both studies showed that leader‐allies' anger expression was associated with greater calls for accountability of the transgressor and more positive impressions of the organization. However, anger expression also wrought highly polarized responses toward the victim, consisting of both support and victim‐blaming. Thus, authentic but measured emotion expression during confrontation is recommended.
The complex rostral morphology and the endoskeleton ossification process of two adult samples of Xiphias gladius (Xiphiidae)
Authors: Pazzaglia Ugo E. , Reguzzoni Marcella , Saroglia Marco , Manconi Renata , Zarattini Guido , Raspanti Mario 
Published: April 2022

AbstractThe authors studied the morphology of the upper and lower jaws, vertebrae and dorsal‐fin rays of the teleost fish Xiphias gladius to analyse the skeletal architecture and ossification pattern. The analogies and differences among these segments were investigated to identify a common morphogenetic denominator of the bone tissue osteogenesis and modeling. The large fat glands in the proximal upper jaw and their relationship to the underlying cartilage (absent in the lower jaw) suggested that there is a mechanism that explains rostral overgrowth in the Xiphiidae and Istiophoriidae families. Thus far, the compact structure of the distal rostrum has been interpreted as being the result of remodeling. Nonetheless, no evidence of cutting cones, scalloped outer border of osteons and sequence of bright–dark bands in polarized light was observed in this study, suggesting a primary osteon texture formed by compacting of collagen matrix and mineral deposition in the fat stroma lacunae of the bone, but without being oriented in layers of the collagen fibrils. A similar histology also characterizes the circular structures present in the other examined segments of the skeleton. The early phases of fibrillogenesis carried out by fibroblast‐like cells occurred farther from the already‐calcified bone surface inside the fat stroma lacunae. The fibrillar matrix was compacted and underwent mineral deposition near the previously calcified bone surface. This pattern of collagen matrix synthesis and calcification was different from that of mammalian osteoblasts, especially concerning the ability to build a lacuno‐canalicular system among cells. Necrosis or apoptosis of the latter and refilling of the empty lacunae by mineral deposits might explain the anosteocytic bone formation.
GmPIN1‐mediated auxin asymmetry regulates leaf petiole angle and plant architecture in soybean
Authors: Zhang Zhongqin , Gao Le , Ke Meiyu , Gao Zhen , Tu Tianli , Huang Laimei , Chen Jiaomei , Guan Yuefeng , Huang Xi , Chen Xu 
Published: April 2022

ABSTRACTCrop breeding during the Green Revolution resulted in high yields largely due to the creation of plants with semi‐dwarf architectures that could tolerate high‐density planting. Although semi‐dwarf varieties have been developed in rice, wheat and maize, none was reported in soybean (Glycine max), and few genes controlling plant architecture have been characterized in soybean. Here, we demonstrate that the auxin efflux transporter PINFORMED1 (GmPIN1), which determines polar auxin transport, regulates the leaf petiole angle in soybean. CRISPR‐Cas9‐induced Gmpin1abc and Gmpin1bc multiple mutants displayed a compact architecture with a smaller petiole angle than wild‐type plants. GmPIN1 transcripts and auxin were distributed asymmetrically in the petiole base, with high levels of GmPIN1a/c transcript and auxin in the lower cells, which resulted in asymmetric cell expansion. By contrast, the (iso)flavonoid content was greater in the upper petiole cells than in the lower cells. Our results suggest that (iso)flavonoids inhibit GmPIN1a/c expression to regulate the petiole angle. Overall, our study demonstrates that a signal cascade that integrates (iso)flavonoid biosynthesis, GmPIN1a/c expression, auxin accumulation, and cell expansion in an asymmetric manner creates a desirable petiole curvature in soybean. This study provides a genetic resource for improving soybean plant architecture.
Good ingredients from foods to vegan cosmetics after COVID‐19 pandemic
Authors: Lee Jinkyung , Kwon Ki Han 
Published: April 2022

AbstractBackgroundNew changes are taking place in the beauty and cosmetology market due to changes in daily life due to coronavirus disease‐19 (COVID‐19) and environmental alteration caused by the spread of live commerce.PurposeThis study technically investigated the future value and direction of vegan cosmetics from food to cosmetics by focusing on good ingredients after COVID‐19 pandemic and changing the needs of consumers in the beauty and cosmetics industry.MethodsThis review paper is a critical literature review, and a narrative review approach has been used for this study. A total of 300–400 references were selected using representative journal search websites such as PubMed, Google Scholar, Scopus, RISS, and ResearchGate, which a total of 45 papers were selected in the final stage based on 2009 to 2022.ResultAs environmental problems increased after the COVID‐19 pandemic, we tried to understand the needs of consumers for vegan cosmetics, which are good ingredients and good cosmetics. Therefore, this narrative review clearly shows the need for beauty and cosmetics industry consumers to pursue good consumption due to the global COVID‐19 pandemic.ConclusionAccordingly, this literature review will need to identify consumer needs for vegan cosmetics that started from vegan foods and develop the applications for the development of customized inner beauty products, customized vegan inner beauty products and/or customized vegan cosmetics using customized cosmetics. This is expected to be used as important marketing materials for the global vegan cosmetics market that confirms new changes in the cosmetics market.
The Discursive and Practical Influence of Spirituality on Civic Engagement
Authors: Steensland Brian , King David P. , Duffy Barbara J. 
Published: April 2022

AbstractReligion has long been recognized as promoting civic engagement. Recent declines in organized religion and growing interest in spirituality raise the question of whether spirituality might also promote civic engagement. Using data from a new nationally representative survey, we assess the independent and joint influence of spirituality and religion on civic life. We find that 40% of respondents perceive spirituality as influencing their civic engagement. Spirituality's influence typically appears in tandem with religion, but when spirituality and religion are distinct, the influence of spirituality is greater and more prevalent. Using two distinct measures, we assess the influence of spirituality on civic engagementat both discursive and practical levels. We find positive associations for both. Spirituality is both a conscious influence and tacit resource in civic life. We close by briefly outlining an agenda for better understanding socially engaged spirituality.
Oral administration of Lactobacillus paracasei N1115 on neonatal mice prevents the intestinal inflammation in adulthood
Authors: Xun Y. , Yan F. , Zhu H. , Feng L. , Zhang D. , Xue Y. , He F. , Wang S. 
Published: April 2022

Abstract
Colonization and development of gut microbiota during early life stage plays a key regulatory role in the establishment of the host–microbial relationship, which was conducive to progressing host immunity and maintaining health throughout the adulthood life span. This study was aimed to evaluate the protective effect from inflammatory bowel disease (IBD) in adulthood based on the early intervention of Lactobacillus paracasei N1115 (LP N1115). LP N1115 treatment was carried out during 2 weeks in postnatal mice. Then the dextran sodium sulphate (DSS)-induced colitis model mice were established in adulthood, and the status of intestinal tissues was detected. Results showed the decreased severity of intestinal tissue injury, cell apoptosis, and proinflammatory cytokines expression in DSS-induced model with LP N1115 early intervention. Therefore, the intake of LP N1115 in neonatal mice has played a long-term healthy role in the prevention of intestinal injury and inflammation in adulthood.
Endophytic fungi isolated from plants present in a mine tailing facility show a differential growth response to lead
Authors: Parada R. , Mendoza L. , Cotoras M. , Ortiz C. 
Published: April 2022

Abstract
Plants growing in metal-polluted sites can be a source of micro-organisms suitable for bio-assisted phytoremediation strategies. In this work, three endophytic fungi from the roots of Poa stuckertii and Poa pratensis, two grasses that naturally colonize a Lead-Zinc tailing storage facility in Southern Chile, were isolated and identified. The leachate of the tailing sands showed a Pb content of 1·36 ± 0·71 ppm, and a pH of 7·3. By amplifying the ITS1/ITS4 region of fungal ribosomal DNA, the isolates were identified as Bjerkandera sp., Microdochium sp. and Sarocladium sp. When the growth media was supplemented with 50 ppm of Pb at pH 4·5, Microdochium sp. showed an 80% decrease in the biomass, but the biomass production of Bjerkandera sp. and Sarocladium sp. was not affected by the same treatment. The accumulation of Pb in Microdochium sp. increased as a function of the concentration of the metal in the growth media, between 48·3 and 241·3 μmol l−1. We showed that two Poaceae plants growing on a Lead-Zinc tailing storage facility are a source of endophyte fungi and that Pb had a differential effect on the growth of the isolated fungi independent of the plant of origin.
Participation in sociolinguistic research
Authors: Bodó Csanád , Barabás Blanka , Fazakas Noémi , Gáspár Judit , Jani‐Demetriou Bernadett , Laihonen Petteri , Lajos Veronika , Szabó Gergely 
Published: April 2022

AbstractInvolving speakers in research on their linguistic practices has been at the core of sociolinguistics since the inception of the field. In contrast to social sciences, however, sociolinguists have rarely addressed the issues surrounding the participation of those involvedandengaged in the research process. This paper aims at reviewing the state of the art and outlining critical dimensions and aspects with relation to participation. We explore previous studies and study designs with the help of the following questions: Who has been involved? How and with what impact have stakeholders participated in different strands of sociolinguistic research? Current developments are presented and reviewed with particular reference to language expertise of those outside academia, as manifested in everyday talk about language, and the link between the production of this knowledge and social inequalities. We point out that the interconnectedness of everyday language expertise and social (in)equality can only be interpreted in highly localised contexts, whose diverse understandings and conceptualisations provide and, at the same time, limit the possibilities of social transformation.