bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foundational Needs of Forecasters for Probabilistic Winter Forecasting
Authors: Tripp Daniel D. , Trujillo-Falcón Joseph E. , Klockow-McClain Kim E. , Reeves Heather D. , Berry Kodi L. , Waldstreicher Jeff S. , Nelson James A. 
Published: October 2022

Abstract
This study explores forecaster perceptions of emerging needs for probabilistic forecasting of winter weather hazards through a nationwide survey disseminated to National Weather Service (NWS) forecasters. Questions addressed four relevant thematic areas: 1) messaging timelines for specific hazards, 2) modeling needs, 3) current preparedness to interpret and communicate probabilistic winter information, and 4) winter forecasting tools. The results suggest that winter hazards are messaged on varying time scales that sometimes do not match the needs of stakeholders. Most participants responded favorably to the idea of incorporating new hazard-specific regional ensemble guidance to fill gaps in the winter forecasting process. Forecasters provided recommendations for ensemble run length and output frequencies that would be needed to capture individual winter hazards. Qualitatively, forecasters expressed more difficulties communicating, rather than interpreting, probabilistic winter hazard information. Differences in training and the need for social-science-driven practices were identified as a few of the drivers limiting forecasters’ ability to provide strategic winter messaging. In the future, forecasters are looking for new winter tools to address forecasting difficulties, enhance stakeholder partnerships, and also be useful to the local community. On the regional scale, an ensemble system could potentially accommodate these needs and provide specialized guidance on timing and sensitive/high-impact winter events.

Significance Statement
Probabilistic information gives forecasters the ability to see a range of potential outcomes so that they can know how much confidence to place in the forecast. In this study, we surveyed forecasters so that we can understand how the research community can support probabilistic forecasting in winter. We found that forecasters want new technologies that help them understand hard forecast situations, improve their communication skills, and that are useful to their local communities. Most forecasters feel comfortable interpreting probabilistic information, but sometimes are not sure how to communicate it to the public. We asked forecasters to share their recommendations for new weather models and tools and we provide an overview of how the research community can support probabilistic winter forecasting efforts.
Low socioeconomic status was associated with a higher mortality risk in multiple sclerosis
Authors: Calocer Floriane , Ng Huah Shin , Zhu Feng , Zhao Yinshan , Dejardin Olivier , Leray Emmanuelle , Defer Gilles , Evans Charity , Fisk John D , Marrie Ruth Ann , Tremlett Helen 
Published: October 2022

Background: The relationship between socioeconomic status (SES) and mortality among persons with multiple sclerosis (PwMS) is poorly understood. Objective: To investigate the association between SES and mortality risk in PwMS. Methods: From health-administrative data, we identified 12,126 incident MS cases with a first demyelinating event (MS ‘onset’) occurring between 1994 and 2017. Cox proportional hazard model assessed the association between socioeconomic status quintiles (SES-Qs) at MS onset and all-cause mortality. Results: Lower SES-Qs were associated with higher mortality risk; adjusted hazard ratios: SES-Q1 (most deprived) =1.61 (95% confidence interval (CI) = 1.36–1.91); SES-Q2 = 1.26 (95% CI = 1.05–1.50); SES-Q3 = 1.22 (95% CI = 1.02–1.46); SES-Q4 = 1.13 (95% CI = 0.94–1.35) versus SES-Q5 (least deprived). Conclusion: A lower SES was associated with higher mortality risk in PwMS.
Insights into proton pump inhibitor-induced photosensitivity: An observational study in a tertiary photobiology service
Authors: Butt Sanaa , McMullan Alexandra , Dawe Robert , Ibbotson Sally 
Published: October 2022

Background: Proton pump inhibitors (PPIs) are extensively prescribed but may cause photosensitivity and drug-induced lupus erythematosus (DILE), which can be overlooked as the drug may have been taken for years prior to presentation. Methods: We reviewed the clinical and investigation findings of patients diagnosed with PPI-induced photosensitivity, diagnosed through the Scottish Photobiology Service. Results: We report 11 patients with median age of onset 61-years and mean duration of PPI ingestion of 5-years [DILE ( n = 6), phototoxicity ( n = 3) and drug-induced solar urticaria through a lupus mechanism ( n = 2)]. Five had Anti-Ro antibodies (three also ANA positive). Predominantly UVA and visible light photosensitivity was observed on phototesting. Discussion: PPIs are a reversible cause of photosensitivity and DILE. Time to onset from drug initiation to symptoms can be prolonged, so clinicians should have a high index of suspicion in those taking PPIs. Most are diagnosed through clinical assessment and lupus serology, with phototesting indicated if there is diagnostic uncertainty.
Can Lumbopelvic Parameters Be Used to Predict Thoracic Kyphosis at all Ages? A National Cross-Sectional Study
Authors: Solla Federico , Ilharreborde Brice , Blondel Benjamin , Prost Solène , Bauduin Eloïse , Laouissat Féthi , Riouallon Guillaume , Wolff Stéphane , Challier Vincent , Obeid Ibrahim , Boissière Louis , Ferrero Emmanuelle , Lamas Vincent , Le Huec Jean-Charles , Bourret Stéphane , Faddoul Joe , Abi Lahoud Georges Naïm , Fière Vincent , Kerckhove Michiel Vande , Lebhar Jonathan , Giorgi Hadrien , Faure Aymeric , Sauleau Erik A. , Pesenti Sébastien , Charles Yann Philippe ,   The French Spine Surgery Society (SFCR)
Published: October 2022

Study design National cross-sectional study. Objective Thoracic kyphosis (TK) is related to sagittal parameters as pelvic tilt (PT), lumbar lordosis (LL) and pelvic incidence (PI). The equation TK = 2 (PT+LL–PI) was validated for adolescents. The purpose of this study was to investigate if this equation correctly predicts TK regardless of age. Methods Sagittal alignment parameters were assessed on full spine radiographs of 2599 individuals without spine pathology (1488 females, 1111 males). Calculated TK (CTK) = 2 (PT+LL–PI) and measured TK (MTK) were compared by calculating the gap and using a linear regression between both parameters. Subgroup analyses were performed for gender, age, TK groups (≤20°, 21°-40°, 41°-60°, >60°), and PI groups (<45°, 45°-60°, >60°). Results Average values in the total population were: MTK 45.0°, CTK 36.9°. Average TK gap was 8.1°, 5.2° in females (intercept 11.7, slope .61) and 11.9° in males (intercept 7.1, slope .58). The mean gap was 3.6° for 15-34 years, 5.7° under 15 years and it increased progressively after 35 years with a maximum of 19.9° over 80 years. The gap also increased with the amount of MTK: -3.5° for TK<20° up to 17.3° for TK >60°. Differences in gaps were minor between PI groups. The intercept was smallest and slopes >.6 for PI <45° and TK ≤20°. Conclusion The formula TK=2 (PT+LL-PI) yielded moderate accuracy for adolescents and young adults, but did not fit for over 35 years and under 15. The amount and variance in TK increased in elderly subjects, which made the formula less accurate.
The Effect of Cervical and Lumbar Decompression Surgery for Spinal Stenosis on Erectile Dysfunction
Authors: Wottrich Stephanie , Kha Stephanie , Thompson Nicolas , Bakar Dara , Yee Philina , Melillo Albert , Nash Christopher , Healy Andrew T. , Steinmetz Michael , Mroz Thomas 
Published: October 2022

Study design Observational study. Objectives To evaluate the prevalence of erectile dysfunction and evaluate the effects of decompressive surgery on erectile dysfunction in cervical spinal stenosis and lumbar canal stenosis patients. Methods This observational, prospective analysis enrolled patients aged 18-80 with cervical spinal stenosis and/or lumbar canal stenosis that underwent respective decompressive surgery. The IIEF-5 questionnaire was administered preoperatively, and at 6- and 12-months postoperatively to assess erectile dysfunction severity. The EPIC database was queried to determine any postoperative complications and document prominent erectile dysfunction risk factors. Results Of 79 patients included in the analysis, 42 (53.2%) completed the IIEF-5 at 6 months, and 62 (78.5%) completed it at 12 months. Eighteen had cervical stenosis only, 54 had lumbar stenosis only, and 7 had both. 72% (18/25) of cervical stenosis patients and 83.6% (51/61) of lumbar stenosis patients had erectile dysfunction preoperatively according to IIEF-5 responses. The average preoperative IIEF-5 score indicated significant presence of erectile dysfunction for both the cervical and lumbar stenosis groups. No significant differences were identified in IIEF-5 score deltas from pre- to both postoperative periods. The presence of erectile dysfunction in both the cervical and lumbar stenosis groups was not significantly associated with the presence of any documented risk factors. Conclusions Our results suggest no significant improvement in overall erectile function postoperatively for patients with preoperative erectile dysfunction. This is important to address during patient counseling for decompression surgery candidates with cervical spinal stenosis and/or lumbar canal stenosis to manage expectations.
Application of supported Cu–Ru catalysts for the removal of trace olefins in aromatics
Authors: Liang Xiao , Liu Naiwang , Shi Li , Meng Xuan 
Published: October 2022

AbstractExploring reliable hydrogenation catalysts to remove trace olefins in aromatic hydrocarbons through hydrogenation is an important topic. In this paper, a bimetallic Cu–Ru/montmorillonite (Cu–Ru/M) catalyst was prepared using a step-by-step impregnation method, and the effects of bimetallic catalysts on removing olefins were assessed. The catalysts were characterized using X-ray diffraction, Brunauer–Emmett–Teller specific surface area, inductively coupled plasma atomic emission spectrometry, high-resolution transmission electron microscopy and temperature-programmed reduction of H2. The results show that there is a strong interaction between Cu and Ru on the Cu–Ru/M catalyst, which improves the dispersion of the metals on the surface of the support M. The hydrogen spillover phenomenon of Cu–Ru/M enhances its activity and adsorption capacity for hydrogen species. The catalytic performance test confirmed that the bimetallic catalyst has significantly greater activity and stability. The optimal loadings are 5% copper and 1% ruthenium, and the performance of this catalyst is comparable to those of noble-metal Pt/M catalysts.
Establishment and evaluation of a prediction model for acute gastrointestinal injury in patients with prolonged disorder of consciousness
Authors: Fu Wenpei , Hu Zhihang , Zhou Xiaomei , Chen Liang , Wang Mei , Zhu Yingying , Qi Yinliang 
Published: October 2022

AbstractObjectiveTo establish a prediction model for acute gastrointestinal injury (AGI) in patients with prolonged disorder of consciousness (pDOC) and to evaluate and apply the prediction model. MethodsThe clinical data of 165 patients with pDOC admitted to the hyperbaric oxygen department from January 2021 to December 2021 were retrospectively reviewed, and the patients were divided into an AGI group (n = 91) and an N-AGI group (n = 74) according to whether AGI occurred. A prediction model was built by fitting multiple independent influencing factors through logistic regression. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the model, the Hosmer–Lemeshow (H–L) test was used to evaluate the goodness-of-fit of the model, and the ROC curve and calibration curve were drawn to evaluate the predictive performance. A nomogram was plotted to visualize the prediction model.ResultsAccording to the multivariate logistic regression analysis results, the prediction model was finally constructed with the CRS-R score, DAO, PCT, ALB, and I-FABP, and a nomogram was generated. The area under the ROC curve (AUC) of the prediction model was 0.931, the sensitivity was 83.5%, and the specificity was 93.2%. The data were divided into 5 groups for the H–L test (χ2 = 2.54,P = 0.468 > 0.05) and into 10 groups for the H–L test (χ2 = 9.98,P = 0.267 > 0.05). A calibration curve was drawn based on the test results, indicating that the prediction model has a good goodness-of-fit and good prediction stability.ConclusionThe prediction model for AGI in pDOC patients constructed in this study can be used in clinical practice and is helpful to predict the occurrence of AGI in pDOC patients.
Preliminary study of confocal laser endomicroscopy for in vitro specimens of the endometrium
Authors: Wen Jia , Yang Xi , Ye Guiying , Chen Rui , Feng Yu , Liao Qinping 
Published: October 2022

Abstract
Background
This study observed and described the morphological characteristics of the endometrium of the resected uterus using confocal laser endomicroscopy. This included benign endometrium, non-atypical endometrial hyperplasia, atypical endometrial hyperplasia, and endometrial carcinoma, thereby laying a foundation for finding the precise localization and resection of endometrial lesions, given the feasibility of confocal laser endomicroscopy-assisted hysteroscopy.

Methods
This prospective study included 32 patients who underwent hysterectomy. We used confocal laser endomicroscopy to observe the endometrium of resected uteruses and described the characteristics of endometrium in different states by comparing histopathological findings (primary objects). The secondary objects of observation were the myometrium, endocervical canal, and surface of the external os of the cervix.

Results
A total of 32 patients who underwent hysterectomy for different diseases were included: 9 with endometrial carcinoma (5 with endometrioid carcinoma, 1 with endometrial serous carcinoma, 2 with clear cell carcinoma, and 1 with carcinosarcoma), 2 with atypical endometrial hyperplasia, 9 with benign diseases, 7 with cervical cancer, and 5 with ovarian cancer and borderline tumor. The dynamic images of the endometrium were observed and recorded using probe-based confocal laser endomicroscopy (pCLE). Considering histopathology as the gold standard, the diagnostic concordance rate of pCLE was 96.9% in patients with endometrial carcinoma and precancerous lesions and 100% in patients with endometrial carcinoma.

Conclusion
Confocal laser endomicroscopy provides real-time high-resolution images of the benign endometrium and endometrial lesions. Compared with histopathology, confocal laser endomicroscopy has high diagnostic accuracy and may become an auxiliary examination tool for hysteroscopy, as it is useful for early identification of endometrial lesions, real-time diagnosis of tumor, and detection of tumor boundaries for complete tumor resection. These findings can lay a foundation for the feasible use of fertility-sparing local excision of tumor lesions by hysteroscopy.
Economic impact of implementing prescription of single-inhaler triple therapies versus current multiple-inhaler triple therapies for COPD in the Apulia Region
Authors: Resta Emanuela , Scioscia Giulia , Lacedonia Donato , Quarato Carla Maria Irene , Panza Francesco , Resta Onofrio , Lepore Giorgia , Buonamico Enrico , Di Lecce Valentina , Carpagnano Giovanna Elisiana , Barbaro Maria Pia Foschino , Rossi Noemi 
Published: October 2022

Abstract
Background
The most impacting direct costs associated to COPD for the National Health Systems (NHS) are those related to accesses to the emergency room and hospital admissions, due to the onset of one or more COPD exacerbations. At the same time, severe COPD treatment, that often require a combination of medicaments, represents a substantial economic burden for the National Health Systems (NHS). This study aimed to evaluate the potential saving deriving from the implementation in the prescription of the two currently available single-inhaler triple therapies (SITTs) versus the currently used multiple-inhaler triple therapies (MITTs) in an eligible COPD population residing in the Apulia Region.

Methods
A budget impact model was developed hypothesizing the progressive replacement of the different MITTs on the reference market (Scenario A) with the pre-established SITTs, assuming a degree of penetration of 30%, 50% and 100% (Scenario B). Drug costs were based on prices published on the Official Gazette and therapy durations were based on prescribing information over the year 2019 (IQVIA™ prescription dataset).

Results
Our analysis showed that the extemporaneous MITT with the highest prevalence on the reference market was the inhaled corticosteroids/long-acting β2-agonists (ICS/LABA) combination plus a long-acting muscarinic antagonists (LAMA). This association of medicaments was paradoxically also the one associated to the highest expense value. The expanded use of a pre-established ICS/LAMA/LABA SITT was associated to a significant economic saving, ranging from a minimum of -€ 1,108,814 (SITT use: 30%) to a maximum of -€ 3,658,950 (SITT use: 100%). The cheapest pre-established SITT contained the fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) combination.

Conclusion
A pre-fixed ICS/LAMA/LABA SITT is cost-saving, compared to the different currently used extemporaneous MITTs. Clinicians should consider the potential benefits of finding less expensive regimens while maintaining adequate efficacy in the prescriptive decision making process of COPD patients.
Optimal control for a chemotaxis–haptotaxis model in two space dimensions
Authors: Tang Hui , Yuan Yunfei 
Published: October 2022

AbstractThis paper deals with a chemotaxis–haptotaxis model which described the process of cancer invasion on the macroscopic scale. We first explore the global-in-time existence and uniqueness of a strong solution. For a class of cost functionals, we prove first-order necessary optimality conditions for the corresponding optimal control problem and establish the existence of Lagrange multipliers. Finally, we derive some extra regularity for the Lagrange multiplier.
Personalizing Activity Recommendations for Individuals with Type 2 Diabetes
Authors: Knaga Julie , Buresh Robert 
Published: October 2022

Apply It!
By reading this article, fitness professionals who work with novice exercisers with type 2 diabetes mellitus (T2DM) will be able to:
• individualize recommendations for activity timing, reducing sedentary time, and modes of exercise to maximize blood sugar control for clients with T2DM;
• summarize the benefits and limitations of step tracking on blood sugar control for individuals with T2DM.
Modal Sosial sebagai Sarana Meningkatkan Rasa Percaya Diri bagi Narapidana untuk Kembali Berbaur dengan Masyarkat
Authors: Aisharahma Hanum , Irhandayani Ana 
Published: October 2022

Modal sosial merupakan kemampuan yang diperlukan dan kemudian dikembangkan oleh individu atau kelompok sebagai modal untuk berosialisasi dengan masyarakat. Maka dari itu, sebagai seseorang yang akan kembali bermasyarakat, modal sosial dibutuhkan juga oleh narapidana. Perpustakaan sebagai salah satu sarana pendukung di Lembaga Pemasyarakatan Kelas I Semarang pun turut berperan dalam memberikan modal sosial bagi narapidana. Modal sosial yang menjadi dasar utama dalam penelitian ini adalah modal sosial menurut Coleman yang terdiri dari 3 pilar, yaitu kepercayaan, informasi, dan norma. Penelitian ini bertujuan untuk mengetahui bagaimana peran yang dilakukan perpustakaan lembaga pemasyarakatan dalam memberikan modal sosial bagi narapidana, khususnya di Lembaga Pemasyarakatan Kelas I Semarang. Dalam melaksanakan penelitian ini, digunakan metode penelitian kualitatif dan teknik pengambilan data menggunakan wawancara dan observasi semi terstruktur. Pemilihan informan dilakukan dengan teknik purposive sampling. Kemudian data yang telah terkumpul dianalisis dengan teknik analisis data menurut Miles & Huberman, yaitu reduksi data, penyajian data, dan penarikan kesimpulan atau verifikasi. Berdasarkan hasil analisis data, didapatkan hasil bahwa perpustakaan di Lembaga Pemasyarakatan Kelas I Semarang merupakan sarana pendukung proses pembinaan narapidana. Sebagai sarana pendukung proses pembinaan tersebut, perpustakaan lembaga pemasyarakatan berperan sebagai sarana pendidikan, sarana informasi, dan sarana rekreasi. Sedangkan peran perpustakaan dalam memberikan modal sosial yang berupa kepercayaan, informasi, dan norma bagi narapidana, diberikan melalui berbagai koleksi bahan bacaan yang disediakan di Perpustakaan Lembaga Pemasyarakatan Kelas I Semarang.
Pasang Surut Kesenian Kesenian Emprak Jepara 1950-2020
Authors: Alamsyah Alamsyah , Maziyah Siti 
Published: October 2022

Jepara mempunyai berbagai kesenian lokal yang salah satunya adalah emprak. Kesenian ini berada di bagian utara Kabupaten Jepara yaitu di Kecamatan Bangsri dan Pakisaji. Bentuk kesenian seperti teater ini memadukan antara cerita, instrumentalia Jawa dan tembang. Keberadaan kesenian emprak dapat dilacak dari cerita lisan masyarakat yang percaya bahwa keberadaan kesenian ini diperkirakan pada masa Wali Songo. Kesenian emprak dipandang sebagai bentuk akulturasi antara budaya lokal dengan budaya luar Jepara serta menjadi salah satu media dakwah. Dalam perkembangannya, kesenian ini mengalami pasang surut. Pada 1950-1999, emprak berkembang pesat. Perkembangan tersebut ditandai dengan adanya berbagai inovasi, baik dalam bentuk tarian, kostum, mengakomodir tambahan peralatan, dan mengkombinasi pementasan dengan organ dan lagu dangdut. Melalui kreativitas tersebut, emprak menjadi populer dan banyak melakukan pementasan di masyarakat Jepara. Pada periode tersebut, emprak mengalami masa keemasan. Memasuki tahun 2000-an, emprak mulai mengalami penurunan. Hal ini disebabkan adanya persaingan pementasan hiburan seperti organ tunggal, hadirnya banyak televisi swasta, dan kompetisi dengan kesenian tradisional yang lain. Pada saat itu, hiburan organ tunggal ini sangat disukai oleh msayarakat dengan biaya yang jauh lebih murah bila dibandingkan dengan biaya pementasan emprak. Kesulitan yang lain adalah kesenian ini masih tergantung pada pelaku seni yang sudah senior. Regenerasi belum berjalan dengan baik. Pada tahun 2020 ini dipandang sebagai puncak kemunduran kesenian emprak. Hal ini disebabkan adanya pandemi Covid 19 yang melarang pementasan. Akibatnya para pemain kesenian lebih memfokuskan pada profesi yang lain untuk memenuhi kebutuhan hidup sehari-hari.