bluuebunny/crossref_metadata_2025_split huggingface dataset:
Democratic and expert legitimacy: Science, politics and the public during the COVID-19 pandemic
Authors: Weingart Peter , van Schalkwyk François , Guenther Lars 
Published: January 2022

AbstractThe COVID-19 pandemic has provided an extraordinary test case for an analysis of the interrelations between policymakers and scientific experts faced with grave decisions and given the respective levels of trust they enjoy. The article provides a comparative analysis between three countries—Germany, the USA and South Africa (SA)—of the interrelation between the public’s perceptions of the threat posed by the pandemic, the trust in governments and in scientific experts formally organized to advise governments, and the acceptance of governments’ decisions to mitigate the pandemic. These scientific experts enjoyed a high degree of acceptance even when admitting uncertainty and the need for further research. Support for politicians also remained high in spite of the severity of the measures implemented and their increasingly evident departure from their experts’ advice. However, trust in politicians deteriorated as the pandemic progressed, most dramatically in the USA, less so in SA and Germany, due to the politicization of the pandemic. The analysis is limited to events during 2020.
Are there political cycles hidden inside collaborative innovation efficiency? An empirical study based on Chinese cities
Authors: Fan Fei , Zhang Xuerong , Wang Xueli 
Published: January 2022

AbstractShifting political interests of government officials stemming from the Provincial Party Congress (PPC) affects the efficiency of urban innovation. In this paper, intra-city collaborative innovation efficiency (CIE) and inter-city CIE were both analyzed. The intra-city CIE among 285 Chinese cities from 2004 to 2018 was estimated using network data envelopment analysis model, with a gravity model utilized to measure inter-city CIE. Based on a fixed-effect model, the relationship between estimated change in CIE and political cycle is revealed from the perspective of PPC. The study finds that across all cities, (1) cyclical fluctuations in CIE synchronize with the timing of PPC. The inter-city CIE is more sensitive to political cycles than that of intra-city. (2) The turnover effect of PPC cannot be equated with leadership transition alone at non-PPC years. Furthermore, heterogeneity analysis identified differential effects of features of government officials and cities on political cycles of urban CIE.
miR319a targeting of CsTCP10 plays an important role in defense against gray blight disease in tea plant (Camellia sinensis)
Authors: Liu Lu , Chen Hongrong , Zhu Junyan , Tao Linglng , Wei Chaoling 
Published: January 2022

Abstract
Gray blight disease occurs widely in major tea-producing areas and harms the leaves of tea trees, which affects the quality and yield of processed tea. According to an analysis of previous sequencing data, miR319a may be important in the resistance of tea plants to gray blight disease. In this study, based on 5′RLM-RACE, qRT-PCR, sODN, CIN and transient transformation experiments in tobacco, CsTCP10 and CsTCP4 were found to be cleaved by miR319a. qRT-PCR and northern blotting also revealed that the expression pattern of CsTCP10 in tea leaves was opposite to that of miR319a, while that of CsTCP4 displayed no similar change. Furthermore, a large amount of reactive oxygen species was found to accumulate in tea leaves in the antisense oligodeoxynucleotide experiment, while the expression of CsTCP10 was inhibited. These results suggest that CsTCP10 is a positive regulator of the resistance of tea plants to gray blight disease. Compared with the wild-type, the expression of AtTCP10 in transgenic Arabidopsis plants was downregulated. After infection with the pathogen, the transgenic plants were more severely damaged. Our results suggest that miR319a facilitates Pestalotiopsis infection by suppressing the expression of CsTCP10 in tea plants.
Normal-pressure hydrocephalus
Authors: Liang Kyle , Chebrolu Puja 
Published: January 2022

ABSTRACT
Normal-pressure hydrocephalus (NPH) is characterized by the clinical triad of dementia, gait instability, and urinary incontinence. The estimated annual incidence is 1.8 cases in 100,000 persons, making NPH a rare diagnosis and uncommon cause of dementia. NPH is a form of communicating hydrocephalus that can easily be missed in older adults with multiple comorbidities, so clinicians must exclude reversible causes of dementia before diagnosing irreversible causes such as Alzheimer disease.
Hairy Cell Leukemia Presenting as Presternal Soft Tissue Mass: A Case Report With Review of Literature
Authors: Murshed Khaled Abdelfattah , Fadul Afraa , Yassin Mohamed A. , Hilmi Feryal , Elsayed Ahmed Mounir , Al-Bozom Issam 
Published: January 2022

Abstract
Hairy cell leukemia (HCL) is an uncommon chronic lymphoproliferative disorder. Initial presentation frequently includes symptoms related to peripheral blood cytopenias. It can sometimes have atypical manifestations and can present at unusual sites. We report an unusual presentation of HCL as a presternal soft tissue mass in a 45-year-old man. His peripheral blood counts showed pancytopenia. There were no palpable lymph nodes or hepatosplenomegaly. CT-scan revealed a middle mediastinal mass with extension into the presternal soft tissue. Tissue core biopsy was taken and histopathologic findings confirmed the diagnosis of HCL. To our knowledge, this is the second reported case of HCL presenting as a presternal soft tissue mass. Although rare, HCL should be considered in the differential diagnosis of tumors involving extramedullary/extranodal sites including the soft tissue and bone, so the patient can get the utmost benefit for early diagnosis of a treatment responsive disease.
Chronic Myelomonocytic Leukemia in a Patient With a Germline Predisposition and Short Telomeres
Authors: Nageshwar Monika , Duong Vu H. , Koka Rima , Singh Zeba , Kallen Michael E. 
Published: January 2022

Abstract
Myeloid neoplasms with germline predisposition are an increasingly recognized category within the World Health Organization classification. Detection requires a high degree of suspicion, with mounting awareness of clinically silent phenotypes and heterogeneous presentations, challenging diagnostic and laboratory testing considerations, need for surveillance of disease progression, and unique concerns in donor selection for stem cell transplantation. We describe the case of a patient who presented as a teenager with thrombocytopenia and was later diagnosed with chronic myelomonocytic leukemia, with eventual transformation to acute myeloid leukemia, which has relapsed after stem cell transplantation. She was found to have short telomeres and a TERT mutation, in addition to numerous features suggestive of a germline predisposition syndrome. These findings have not been specifically associated with chronic myelomonocytic leukemia and raise interesting questions about the associations between myelodysplastic/myeloproliferative neoplasms, telomere biology disorders, and the roles of specific myeloid mutations as drivers of disease.
Implant-Based Reconstruction following Mastectomy in Patients Who Have Had a Previous Breast Augmentation: Lessons from the National Multicenter Implant Breast Reconstruction Evaluation Study
Authors: Baker Benjamin G. , Sewart Emma , Harvey James , Potter Shelley ,   On behalf of the Implant Breast Reconstruction Evaluation Study Steering Group and Breast Reconstruction Research Collaborative
Published: January 2022

Background:
Breast augmentation is the most commonly performed cosmetic procedure, and increasingly women in this group present with breast cancer or request risk-reducing surgery, but their optimal management is unclear. The authors explored the clinical and patient-reported outcomes of patients undergoing immediate implant-based breast reconstruction following previous augmentation and compared these with outcomes of patients who had not had cosmetic implants in the Implant Breast Reconstruction Evaluation (iBRA) Study.

Methods:
Patients undergoing immediate implant-based breast reconstruction were prospectively recruited from breast and plastic surgical units across the United Kingdom. Demographic, operative, and oncologic data, and information regarding complications within 3 postoperative months were collected. Patient-reported outcomes at 18 months were assessed using the BREAST-Q. The clinical and patient-reported outcomes of patients undergoing immediate implant-based breast reconstruction with and without previous breast augmentation were compared.

Results:
A total of 2108 women were included in the iBRA Study, of whom 49 had undergone a previous augmentation. Women in the augmentation group were younger (median age, 45 years versus 50 years; p = 0.01), had a lower body mass index (22.8 kg/m2 versus 24.9 kg/m2; p < 0.01), and had smaller tumors (15 mm versus 25 mm; p = 0.01) than patients without augmentation. No differences were seen in operative technique between the groups. Complications at 3 months were similar in both groups and there were no significant differences in patient-reported outcomes at 18 months.

Conclusions:
The clinical and patient-reported outcomes of patients undergoing immediate implant-based breast reconstruction following previous augmentation are consistent with those observed in the wider iBRA Study cohort, supporting the safety of this approach.
Clarifying the Anatomy of the Zygomatic Cutaneous Ligament: Its Application in Midface Rejuvenation
Authors: Duan Jing , Cong Li-Yao , Luo Cheng-En , Luo Sheng-Kang 
Published: January 2022

Background:
Anatomical knowledge of the zygomatic cutaneous ligament is crucial for rejuvenation of the anteromedial midface. However, there is a lack of satisfactory descriptions of the anatomy of the zygomatic cutaneous ligament, and the exact range and location are still controversial. The present study attempts to clarify the anatomy of the zygomatic cutaneous ligament to provide vital information for clinical operations.

Methods:
Facial dissection was performed on 36 cadaver hemifaces. The location of the zygomatic cutaneous ligament was investigated and recorded relative to the Frankfort horizontal line and several vertical reference lines. The relative relationship of the zygomatic cutaneous ligament with surrounding anatomical structures was also investigated.

Results:
The zygomatic cutaneous ligament is a septum-like osteocutaneous ligament originating from the periosteum of the maxilla and zygoma. The overall range of the zygomatic cutaneous ligament starts at the origin of the levator labii superioris and then extends laterally, following the curvature of the inferior bone margin. After merging with the ligamentous part at the origin of zygomaticus minor and zygomaticus major muscle (11.65 mm inferior to the horizontal line), it continues as the zygomatic retaining ligament on the zygomatic arch. The vertical distances between the zygomatic cutaneous ligament and horizontal line along the L1, L2, L3, L4, and L5 reference lines are 9.1, 19.5, 22.1, 21.7, and 18.7 mm, respectively.

Conclusion:
The anatomical data obtained in the present study regarding the location of the zygomatic cutaneous ligament might be valuable for understanding the appearance of the midcheek fold and be helpful for surgical procedures to rejuvenate the anteromedial midface.
Smooth versus Textured Implants and Their Association with the Frequency of Capsular Contracture in Primary Breast Augmentation
Authors: Filiciani Sandra , Siemienczuk Guillermo F. , Etcheverry Mariano G. 
Published: January 2022

Background:
Capsular contracture is the most frequent complication of breast implant augmentation. Although studies indicate that textured implants have a low incidence of contracture, they have been associated with anaplastic cell lymphoma, which influences the choice of surface. This study estimated and compared the annual capsular contracture rate of both smooth and textured implants in primary breast implants.

Methods:
Two hundred fifty-three patients (506 implants) were evaluated from January of 2017 to July of 2019; 42.2 percent of the implants were smooth and 57.8 percent were textured. The inframammary approach was used in the subfascial (55.3 percent) and submuscular (44.7 percent) pockets. The primary outcome was the appearance of capsular contracture (Baker grade II, III, and IV) within the first postoperative year.

Results:
Smooth implants had a higher capsular contracture rate at 1 year postoperatively compared with textured implants, although with borderline statistical significance (p = 0.06). Smooth surface breast implants in the subfascial plane had a 4-fold higher risk of contracture than those with a textured surface in the same plane (OR, 4.4; 95 percent confidence interval, 1.6 to 12.4). However, when placed in the submuscular plane, both textures had a similar contracture risk. The rate of contracture was similar after 2 years postoperatively (p = 0.21).

Conclusions:
Using the inframammary approach and a standardized technique, there were no significant differences in the incidence of capsular contracture between the smooth and textured implants. In the subfascial plane, the contracture rate with smooth implants was higher than with textured implants. However, in the submuscular plane, there was no difference between the surfaces.

CLINICAL QUESTION/LEVEL OF EVIDENCW:
Therapeutic, III.
Relationship between Preoperative Abdominal Wall Strength and Bulging at the Abdominal Free Flap Donor Site for Breast Reconstruction
Authors: Tokumoto Hideki , Akita Shinsuke , Kubota Yoshitaka , Mitsukawa Nobuyuki 
Published: January 2022

Background:
Abdominal bulging at the donor site of free abdominal flaps for breast reconstruction is a common postoperative complication. In addition to the thickness of abdominal muscles, the authors identified the rectus abdominis diastasis as an important factor that compromises abdominal wall strength. This study aimed to assess the relationship between preoperative abdominal wall strength and postoperative abdominal bulging.

Methods:
A total of 224 patients were enrolled in this study. Patient demographics, the rectus and lateral abdominis muscle thicknesses, and the rate of rectus abdominis diastasis were compared (with versus without bulging). Muscle thickness and rectus abdominis diastasis were investigated by preoperative computed tomography.

Results:
The group with bulging consisted of 32 patients (14.3 percent), whereas the group without bulging consisted of 192 patients. The group with bulging had a significantly higher gestational history rate. The thickness of the rectus abdominis muscle in the group with bulging was significantly thinner (median, 8.6 mm versus 10.5 mm; p < 0.001) and the rate of rectus abdominis diastasis was significantly higher (78.1 percent versus 32.3 percent; p < 0.001). There were no significant differences with respect to the thickness of the lateral abdominal muscle and the other factors (i.e., age, body mass index, history of laparotomy. and operative details).

Conclusions:
Because the diagnosis of abdominal bulging was based on severity, the rate may be high compared to that reported from previous studies. Because the factor of gestational history correlated to thickness of the rectus abdominis muscle and rectus abdominis diastasis, this factor influenced the occurrence of abdominal bulging. Patients with a thin rectus abdominis muscle and rectus abdominis diastasis were at higher risk of abdominal bulging.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Risk, III.
Life-long effects of malnutrition using semi-quantitative EEG analysis
Authors: Razzaq Fuleah A. , Reyes Ana Calzada , Tang Qin , Guo Yanbo , Liu Yujie , Galan-Garcia Lidice , Gallagher Anne , Virues-Alba Trinidad , Suarez-Murias Carlos , Rabinowitz A. Arielle , Miranda Ileana , Lagomasino Vivian Bernardo , Galler Janina R , Bringas-Vega Maria L. , Valdes-Sosa Pedro A. 
Published: January 2022

1ABSTRACTThe non-linear spatiotemporal features in the continuing EEG recordings could be helpful to infer the physio and pathological significance of early insults on the brain, such as early malnutrition and their long-term effects. A unique opportunity is opened with the Barbados Nutrition Study (BNS) dedicated to studying Protein-Energy Malnutrition (PEM) with two groups, children suffering an early PEM episode and their controls. We evaluated the resting-state EEG (N=108, PEM=46) in 1978, and we repeated the EEG (N=97, PEM=46) in 2018. We did a qualitative analysis of the EEG using a semi-quantitative scale (Grand Total EEG (GTE)) and an item response theory (IRT) approach to estimate a latent variable that is able to explain the subjacent neurophysiological status (NPS). Finally, we applied a mixed-effects model with a sensitivity index for ignorability to test differences between the controls and PEM groups while accounting for the missing data mechanisms (nlme (Pinheiro J. 2020) and the ISNI package in R(Xie et al., 2018). The fixed effects were group, age, gender, and socioeconomic status; the random effect was the variability inherent to each participant and evaluator.ResultsThe simple visual inspection of the 1978 EEG recordings detected 39 participants with abnormalities (28 PEM and 11 Controls; p<0.05); in 2018, a total of 63 participants showed abnormalities in the EEG recordings (35 PEM and 28 Controls; p<0.01)).The polytomous IRT analysis revealed that all items had been loaded well onto the latent factor, and the highest value of the Focal abnormality reached 0.97. The fixed effect of the groups (PEM vs. Control) was highly significant, with a p-value of 0 and the c index of 5.27. Age was also significant with a p-value of 0.0093 and the c index of 14.793, whereas Gender and SES were not significant. The contrasts at the two different time points (childhood (1978) mean age= 8.45, adulthood (2018) mean age=48.30) also showed highly significant differences between groups with a p-value of 0.
ConclusionsEEG abnormalities were seen in both PEM and control groups during the school years and later in middle adulthood, with a higher proportion of abnormalities in the previously malnourished BNS participants at both ages. The statistical significance of these differences was confirmed through a latent variable approach and a linear mixed-effect model, which discriminated successfully against the long-term effects of early malnutrition on the brain up to 50 years after the onset of malnutrition in the first year of life.
Effectiveness of Pfizer-BioNTech Vaccine Against COVID-19 Associated Hospitalizations among Lebanese Adults ≥75 years- Lebanon, April-May 2021
Authors: Farah Zeina , Haddad Nadine , Naja Hala Abou El , Saleh Majd , Mrad Pamela , Ghosn Nada 
Published: January 2022

AbstractIntroductionIn Lebanon, the nationwide vaccination against COVID-19 was launched in February-2021 using Pfizer-BioNTech vaccine and prioritizing elderly, persons with comorbidities and healthcare workers. Our study aims to estimate the post-introduction vaccine effectiveness (VE) of Pfizer-BioNTech in preventing COVID-19 hospitalization among ≥75 years in Lebanon.MethodsA case-control study design was used. Cases were Lebanese, ≥75 years and hospitalized with positive PCR result during April-May 2021. Cases were randomly selected from the COVID-19 database of the Epidemiological Surveillance Unit(ESU) at the Ministry of Public Health(MOPH). Each case was matched by age and locality to 2 controls. Controls were hospitalized, non-COVID-19 patients with negative PCR result, randomly selected from the MOPH hospital admission database. VE was calculated for fully and partially vaccinated, using multivariate conditional logistic regression analyses.Results345 cases and 814 controls were recruited. Half were females, with a mean age of 83 years. 14 cases(5%) and 143 controls(22%) were fully vaccinated. Bivariate analysis showed significant association with: gender, month of confirmation/admission, general health, chronic medical conditions, main income source and living arrangement. After adjusting for month of admission and gender, multivariate analysis yielded a VE of 82% (95%CI = 69%-90%) against COVID-19 associated hospitalization for those fully vaccinated and 53% (95%CI = 23%-71%) for those partially vaccinated (≥14 days of first or within 14 days of second dose).ConclusionsOur study showed that Pfizer-BioNTech vaccine is effective in reducing risk for COVID-19– associated hospitalization in Lebanese elderly(≥75 years). Additional studies are warranted to explore vaccine effectiveness in reducing hospitalization in younger age groups, as well as in reducing covid-19 infections.
The influence of sex steroid treatment on insular connectivity in gender dysphoria
Authors: Reed Murray B , Handschuh Patricia A , Klöbl Manfred , Konadu Melisande E , Kaufmann Ulrike , Hahn Andreas , Kranz Georg S , Spies Marie , Lanzenberger Rupert 
Published: January 2022

AbstractThe influence of sex hormones on brain function has been investigated in multiple neuroimaging studies. Sexually dimorphic characteristics were found for the insular cortex, though little is known about hormonal effects on sex-specific functional connectivity patterns and insular functions ranging from emotion regulation to interoception and higher-level cognition. Thus, better understanding of direct sex steroid effects on insular connectivity remains essential. Thereby, gender-dysphoric individuals receiving gender-affirming hormone therapy represent an interesting cohort to address this gap in available knowledge.To analyze the potential effect of sex steroids on insular connectivity at rest, 14 transgender women, 19 transgender men, 24 cisgender women, and 15 cisgender men were recruited. All participants underwent two magnetic resonance imaging sessions involving resting-state acquisitions separated by a median time period of 4.5 months. Between scans, transgender subjects received gender-affirming hormone therapy.A seed based functional connectivity analysis revealed a significant 2-way interaction effect of group-by-time between right insula, cingulum, left middle frontal gyrus and left angular gyrus. Post-hoc tests revealed an increase in connectivity for transgender women when compared to cisgender men. Furthermore, spectral dynamic causal modelling showed reduced effective connectivity from the posterior cingulum and left angular gyrus to the left middle frontal gyrus as well as from the right insula to the left middle frontal gyrus.These findings suggest a considerable influence of long-term estrogen administration and androgen suppression on brain networks implicated in interoception, own-body perception and higher-level cognition. Nevertheless, further studies are needed to shed light on the underlying mechanisms.
Significance of the RBD mutations in the SARS-CoV-2 Omicron: from spike opening to antibody escape and cell attachment
Authors: Hossen Md Lokman , Baral Prabin , Sharma Tej , Gerstman Bernard , Chapagain Prem 
Published: January 2022

AbstractWe computationally investigated the role of the Omicron RBD mutations on its structure and interactions with ACE2. Our results suggest that, compared to the WT and Delta, the mutations in the Omicron RBD facilitate a more efficient RBD opening and ACE2 attachment. These effects, combined with antibody evasion, may contribute to its dominance over Delta. While the Omicron RBD escapes most antibodies from prior infections, epitope analysis shows that it harbors sequences with significantly improved antigenicity compared to other variants, suggesting more potent Omicron-specific neutralizing antibodies.