bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of interstitial pneumonia with autoimmune features and idiopathic pulmonary fibrosis are enhanced by involvement of matrix metalloproteinases levels and clinical diagnosis
Authors: Liu Mingtao , Xue Mingshan , Zhang Teng , Lin Runpei , Guo Baojun , Chen Youpeng , Cheng Zhangkai J. , Sun Baoqing 
Published: October 2022

AbstractBackgroundHigher detection of interstitial pneumonia with autoimmune features (IPAF), and idiopathic pulmonary fibrosis (IPF), has significant diagnostic and therapeutic implications. Some matrix metalloproteinases (MMPs) have become reliable diagnostic biomarkers in IPAF and IPF in previous studies, yet relevant reliability remains to be recognized.Materials and MethodsIn this study, 36 ILDs patients, including 31 IPAF patients (Mean ± SD, 50.20 ± 5.10 years; 16 [51.6%] females) and five IPF patients (Mean ± SD, 61.20 ± 6.73 years; one [20.0%] females) were retrospectively enrolled. Serial serum samples were collected from patients with IPAF and IPF between January 2019 and December 2020. Notably, Serum MMPs levels were measured by U‐PLEX Biomarker Group 1(Human) Multiplex Assays (MSD, USA).ResultsA combination of MMPs and combinatorial biomarkers was strongly associated with clinical subjects in this study (AUC, 0.597 for Stability vs. Improvement and 0.756 for Stability vs. Exacerbation). Importantly, the AUC of MMP‐12 reaches 0.730 (p < 0.05, Stability AUC vs. Improvement AUC) while MMP‐13 reaches 0.741 (p < 0.05, Stability AUC vs. Exacerbation AUC) showed better performance than other MMPs in two comparisons.ConclusionsClinical risk factors and MMPs are strongly associated with either stratification of the disease of progression of IPAF or in two IPAF and IPF independent cohorts. To our knowledge, this is the first to illustrate that MMP‐12 and MMP‐13 may be expected to become typical promising biomarkers in Improvement – IPAF and Exacerbation – IPAF, respectively.
Socioeconomic status and access to psychotherapy
Authors: Niemeyer Helen , Knaevelsrud Christine 
Published: October 2022

AbstractObjectiveIndividuals with low socioeconomic status (SES) have significantly higher prevalence rates of mental disorders than those with higher SES, but are less likely to receive treatment. Studies from the United States show that individuals with higher SES are more likely to be offered a therapy place than those with low SES. In Germany, where the public health care system is without financial barriers, studies on access to treatment are lacking.MethodThe present study investigated whether the SES of persons seeking psychotherapeutic help in Germany influences psychotherapists' decision to provide access to treatment. For this purpose, 504 licensed outpatient psychological psychotherapists participated in an online study, in which they read a series of case vignettes and rated how likely they would be to offer treatment in each case. SES was operationalized by occupation and language use. Additionally, we investigated whether treatment offers were affected by the disorder and the gender of the help seeker, the therapists' socioeconomic background, and other characteristics in interaction with SES. Bonferroni‐corrected multifactorial repeated measures analysis of variances (ANOVAs) and mixed ANOVAs were calculated.ResultsHelp seekers with low SES were 4.1% less likely to be offered treatment than those with moderate to high SES (F (1, 503) = 115.64; p = 0.000; η² =  0.187). The influence of SES on the probability of a therapy place offer varied significantly depending on the patient's disorder (p = 0.000): SES had a greater effect for bulimia than for depression and social anxiety disorder. Overall, the effect was small (η² = 0.026). No significant interaction between the gender of potential clients and SES was found (p = 0.062). The influence of SES on treatment accessibility varied depending on the therapeutic method for which the therapist was licensed and on the social status of the district in which the therapist's practice was located. The therapist's socioeconomic background (parental SES) did not interact with the potential client's SES.ConclusionTherapist biases contributing to unequal access to treatment for individuals with low SES and other characteristics can aggravate mental health care disparities. Even though the effects we found were relatively modest, awareness of the association between SES and offers of therapy places might help practitioners to reflect on their own selection practices.
The JMJD6/HURP axis promotes cell migration via NF‐κB‐dependent centrosome repositioning and Cdc42‐mediated Golgi repositioning
Authors: Huang Yun‐Ru Jaoying , Chiu Shao‐Chih , Tseng Jeng‐Sen , Chen Jo‐Mei Maureen , Wei Tong‐You Wade , Chu Chen‐Yu , Kao Hsu‐Ting Eric , Yang Chieh‐Yun Oprah , Shih Yong‐Chun Erin , Yang Tsung‐Ying , Chiu Kun‐Yuan , Teng Chieh‐Lin Jerry , Yu Chang‐Tze Ricky 
Published: October 2022

AbstractGolgi apparatus (GA) and centrosome reposition toward cell leading end during directional cell migration in a coupling way, thereby determining cell polarity by transporting essential factors to the proximal plasma membrane. The study provides mechanistic insights into how GA repositioning (GR) is regulated, and how GR and centrosome repositioning (CR) are coupled. Our previous published works reveals that PRMT5 methylates HURP at R122 and the HURP m122 inhibits GR and cell migration by stabilizing GA‐associated acetyl‐tubulin and then rigidifying GA. The current study further shows that the demethylase JMJD6‐guided demethylation of HURP at R122 promotes GR and cell migration. The HURP methylation mimicking mutant 122 F blocks JMJD6‐induced GR and cell migration, suggesting JMJD6 relays GR stimulating signal to HURP. Mechanistic studies reveal that the HURP methylation deficiency mutant 122 K promotes GR through NF‐κB‐induced CR and subsequently CR‐dependent Cdc42 upregulation, where Cdc42 couples CR to GR. Taken together, HURP methylation statuses provide a unique opportunity to understand how GR is regulated, and the GA intrinsic mechanism controlling Golgi rigidity and the GA extrinsic mechanism involving NF‐κB‐CR‐Cdc42 cascade collectively dictate GR.
An evaluation with shear wave elastography of kidney elasticity in patients with familial Mediterranean fever
Authors: Kayalı Alperen , Öztürk Keleş Fatma , Seyfettin Ayça , Dirican Emre , Çelik Muhammed Murat 
Published: October 2022

AbstractPurposeTo investigate the changes in kidney elasticity in patients with familial Mediterranean fever using the non‐invasive diagnostic method of shear wave elastography (SWE).MethodsThe kidney elasticity of 35 FMF patients and 23 healthy control subjects was evaluated with SWE. The relationships were evaluated of the SWE values with eGFR, microproteinuria, FMF severity score, number of attacks per month, and colchicine doses of the FMF patients.ResultsThe kidney stiffness and velocity values of the FMF patients were found to be higher than those of the control group (p < 0.001). A negative correlation was found between the renal stiffness and velocity values and the colchicine dose (r = −0.48, p = 0.004, and r = −0.50, p = 0.003, respectively).ConclusionThe results of the current study demonstrated that the SWE values of the FMF patients were significantly higher than those of the control group. SWE can be used as an alternative method in the follow up of FMF patients. In addition, a negative correlation was determined between the colchicine dose and renal stiffness. This suggests that SWE values could be used in the adjustments of colchicine doses. However, there is a need for further studies with greater numbers of patients to support this hypothesis.
Introducing dental students to complete denture treatment in times of COVID‐19: Students’ responses
Authors: Bak Sun‐Yung , Saglik Berna , Inglehart Marita R. 
Published: October 2022

AbstractObjectivesThe COVID‐19 pandemic required changes in the complete denture courses to comply with lock‐in and social distancing requirements. The objectives were to assess (a) dental students’ interest in a required complete denture course and the prosthodontics specialty, (b) how much time students spent on studying background, lab, and clinical content, and (c) how difficult and helpful course components were. Additionally, open‐ended responses concerning what the students liked and what they wanted to have changed were analyzed as well.MethodsAfter this “complete denture” course, 81 of 109 students responded to a web‐based survey with questions about course content and design. This hybrid course consisted of weekly asynchronous virtual lectures, in‐person simulated laboratory (sim lab) exercises, and synchronous virtual workshops.ResultsExactly 53.7% were much/very much interested in this course, with nobody considering prosthodontics as their specialty. The students studied on average of 79.61 minutes for 1 hour (of background‐related lecture, 69.92 minutes for a lab‐based lecture, and 77.00 minutes for a clinical‐content lecture (p < 0.001). They evaluated clinical content as most difficult, lab content as less difficult, and background material as least difficult (3‐point scale with 1 = not at all difficult: means = 1.90/1.85/1.80; p < 0.001). They rated background lectures as least helpful, clinical material as more helpful, and lab content as most helpful (5‐point scale with 1 = most helpful: means = 2.33/2.67/2.96; p < 0.001). Open‐ended answers showed exceptionally positive responses for content and pedagogy of sim lab and clinical content.ConclusionsGaining a better understanding of students’ responses to hybrid “complete denture” courses is critical for optimally teaching this material in times of COVID‐19.
Microscopic visualization of the antibiofilm potential of essential oils against Staphylococcus aureus and Klebsiella pneumoniae
Authors: Sarwar Warda , Ali Qurban , Ahmed Safia 
Published: October 2022

AbstractBiofilms are known to pose great risks in clinical settings, drinking water systems, and food industries as they show considerable resistance to various environmental stresses. This study investigates the antibiofilm potential of different essential oils against the test organisms Staphylococcus aureus (ATCC 25923) and Klebsiella pneumoniae (ATCC 13883). Moreover, different stages of biofilm formation were also assessed using light microscopic assays. For determining the antibiofilm activity, a total of five essential oils namely cinnamon (Cinnamomum Verum), tea tree (Melaleuca alternifolia), lavender (Lavandula), peppermint (Mentha piperita), and lemongrass (Cymbopogon citratus) were tested for their ability to inhibit the initial attachment of microbial cells as well as the eradication of mature biofilm using the microtitre plate assay. For both the test strains (S. aureus and K. pneumoniae) the concentration of 30 μl/100 μl of cinnamon oil exhibited the highest antibiofilm activity followed by the activity of peppermint oil at the same concentration. These results were further validated by employing the light microscopy assay for observing the antibiofilm potential of cinnamon and peppermint essential oils.
Facility‐based HIV self‐testing strategies may substantially and cost‐effectively increase the number of men and youth tested for HIV in Malawi: results from an individual‐based mathematical model
Authors: Nichols Brooke E. , de Nooy Alexandra , Benade Mariet , Balakasi Kelvin , Mphande Misheck , Rao Gabriella , Claassen Cassidy W. , Khan Shaukat , Stillson Christian , Russell Colin A. , Doi Naoko , Dovel Kathryn 
Published: October 2022

AbstractIntroductionMalawi is rapidly closing the gap in achieving the UNAIDS 95‐95‐95 targets, with 90% of people living with HIV in Malawi aware of their status. As we approach epidemic control, interventions to improve coverage will become more costly. There is, therefore, an urgent need to identify innovative and low‐cost strategies to maintain and increase testing coverage without diverting resources from other HIV services. The objective of this study is to model different combinations of facility‐based HIV testing modalities and determine the most cost‐effective strategy to increase the proportion of men and youth testing for HIV.MethodsA data‐driven individual‐based model was parameterized with data from a community‐representative survey (socio‐demographic, health service utilization and HIV testing history) of men and youth in Malawi (data collected August 2019). In total, 79 different strategies for the implementation of HIV self‐testing (HIVST) and provider‐initiated‐testing‐and‐counselling at the outpatient department (OPD) were evaluated. Outcomes included percent of men/youth tested for HIV in a 12‐month period, cost‐effectiveness and human resource requirements. The testing yield was assumed to be constant across the scenarios.ResultsFacility‐based HIVST offered year‐round resulted in the greatest increase in the proportion of men and youth tested in the OPD (from 45% to 72%–83%), was considered cost‐saving for HIVST kit priced at $1.00, and generally reduced required personnel as compared to the status quo. At higher HIVST kit prices, and more relaxed eligibility criteria, all scenarios that considered year‐round HIVST in the OPD remained on the cost‐effectiveness frontier.ConclusionsFacility‐based HIVST is a cost‐effective strategy to increase the proportion of men/youth tested for HIV in Malawi and decreases the human resource requirements for HIV testing in the OPD—providing additional healthcare worker time for other priority healthcare activities.
Research on quality control methods for surface temperature observations via spatial correlation analysis
Authors: Xiong Xiong , Jiang Zhongbao , Tang Hongsheng , Zhang Yinchao , Ye Xiaoling 
Published: October 2022

AbstractThis article proposed a new quality control method (CS‐MSF) to identify potential outliers in the surface temperature observations. The CS‐MSF method employed cosine similarity and moving surface fitting to obtain the estimated value of the target station. For the regions with complex terrain and low weather station density, another quality control method (CE‐GBDT) was employed to compensate for the shortcomings of CS‐MSF. Compared to the spatial regression test method (SRT) and inverse distance weighting method (IDW), the results indicated that CS‐MSF outperformed SRT and IDW in all the cases. And CE‐GBDT was superior to the other methods for the regions with complex terrain and low weather station density. The comparison results led to the recommendation that the two proposed methods are effective quality control methods in identifying the seeded errors for the surface temperature observations.
Effects of the GABA(B) agonist baclofen on volitional swallowing in normal subjects
Authors: Hung Jui‐Sheng , Liang Shu‐Wei , Omari Taher , Wong Ming‐Wun , Lei Wei‐Yi , Yi Chih‐Hsun , Liu Tso‐Tsai , Lin Lin , Chen Chien‐Lin 
Published: October 2022

AbstractThe GABA(B) receptor agonist baclofen is known to suppress the rate of spontaneous swallowing but not pharyngeal muscle contraction. The extent to which baclofen may alter volitional swallowing is not currently known. We investigated the effects of baclofen in healthy subjects, hypothesizing that baclofen exposure would alter volume‐regulation and/or piecemeal deglutition behaviors during volitional swallowing attempts. Pharyngeal high‐resolution manometry impedance (P‐HRM‐I) protocol was used to assess swallowing function of 22 healthy adult volunteers (median 29 years) who were investigated on two occasions, receiving 40 mg baclofen (oral) 1 h before study, or placebo (randomized). Standard swallow function variables recommended by the pharyngeal HRM Working Group were derived for 5 ml, 10 ml, and 20 ml volumes of thin and extremely thick liquid challenges. Multiple swallow behaviors, comprising two swallows <5 s apart, were characterized. The spontaneous swallow rate was also determined. Baclofen exposure had no overall significant effect on swallow variables. Upper esophageal sphincter pressure was weaker during exposure to baclofen, during both the pre‐deglutitive and post‐deglutitive phases of the swallow (p < 0.05 during thick liquid swallows). Piecemeal swallows, where the bolus is separated in two potions, were significantly more common during 20 ml boluses (p = 0.002). Baclofen decreased the frequency of piecemeal deglutition overall. Baclofen has limited to no effect on volitional swallowing measures, however, does reduce the likelihood of initiation of piecemeal deglutition to large volume challenges.
The Quality of Otolaryngology‐ Head and Neck Surgery Literature over the Last Decade
Authors: Coulter Michael , Greene Howard , Miller Tanner , Brady Rebecca , Bennett Chandler , Johnson Christopher 
Published: October 2022

ObjectiveTo describe the changes in the quality of the Otolaryngology‐Head and Neck Surgery (OTOHNS) literature over the last decade, and compare it to other surgical‐based fields.MethodsBased on impact factors, the top eight clinical U.S. OTOHNS journals were selected, and articles were analyzed from 2020 (Oto 2020) and compared to 2010 (Oto 2010). This was done similarly for Neurosurgery, Orthopedic, Ophthalmology, and General Surgery journals in 2020 (non‐Oto). To limit bias and account for random variability, the first 10 research articles from each journal in each group were included. Data regarding the study type, level of evidence, use of confidence intervals, and funding source were collected.ResultsBased on an a priori power analysis, 160 articles were analyzed for Oto 2010 and Oto 2020. Compared to Oto 2020, Oto 2010 had more level 1 and 2 evidence (12 vs. 4; p = 0.032) and less reporting of confidence intervals (10 vs. 32; p < 0.001). Comparing the top 160 articles from 2020 from Non‐Oto and OTOHNS (Oto), Non‐Oto had more level 1 and 2 evidence (19 vs. 6; p = 0.0047), more randomized controlled trials (8 vs. 1; p = 0.016), and less reporting of confidence intervals (42 vs. 58; p = 0.009).ConclusionHigh quality studies remain relatively scarce in the OTOHNS literature. Although reporting of confidence intervals has improved over the last decade, aggregate levels of evidence and extramurally funded studies lag behind other surgical‐based fields. Better study design will provide stronger evidence basis, in hopes of improving clinical care.Level of EvidenceN/A Laryngoscope, 133:1853–1856, 2023
Multiple/Two‐Way Shape Memory Poly(urethane‐urea‐amide) Elastomers
Authors: Li Zhen , Mei Shuxiang , Luo Lu , Li Siyuan , Chen Xiaoyin , Zhang Yuancheng , Zhao Wei , Zhang Xiaomeng , Shi Ge , He Yanjie , Cui Zhe , Fu Peng , Pang Xinchang , Liu Minying 
Published: October 2022

AbstractMultiple and two‐way reversible shape memory polymers (M/2W‐SMPs) are highly promising for many fields due to large deformation, lightweight, strong recovery stress, and fast response rates. Herein, a semi‐crystalline block poly(urethane‐urea‐amide) elastomers (PUUAs) are prepared by the copolymerization of isocyanate‐terminated polyurethane (OPU) and amino‐terminated oligomeric polyamide‐1212 (OPA). PUUAs, composed of OPA as stationary phase and PTMEG as reversible phase, exhibit excellent rigidity, flexibility, and resilience, and cPUUA‐C7‐S25 exhibits the best tensile property with strength of 10.3 MPa and elongation at break of 360.2%. Besides, all the PUUAs possess two crystallization/melting temperatures and a glass transition temperature, which endow PUUAs with multiple and reversible two‐way shape memory effect (M/2W‐SME). Physically crosslinked PUUA‐C0‐S25 exhibits excellent dual and triple shape memory, and micro chemically crosslinked cPUUA‐C7‐S25 further shows quadruple shape memory behavior. Additionally, both PUUA‐C0‐S25 and cPUUA‐C7‐S25 have 2W‐SME. Intriguingly, cPUUA‐C7‐S25 can achieve a higher temperature (up to 165 °C) SME, which makes it suitable for more complex and changeable applications. Based on the advantages of M/2W‐SME, a temperature‐responsive application scenario where PUUAs can transform spontaneously among different shapes is designed. These unique M/2W‐SME and high‐temperature SME will enable the applications of high‐temperature sensors, actuators, and aerospace equipment.
Associations of mitochondrial DNA copy number with incident risks of gastrointestinal cancers: A prospective case–cohort study
Authors: Guan Xin , Li Mengying , Bai Yansen , Feng Yue , Li Guyanan , Wei Wei , Fu Ming , Li Hang , Wang Chenming , Jie Jiali , Meng Hua , Wu Xiulong , Deng Qilin , Li Fangqing , Yang Handong , Zhang Xiaomin , He Meian , Guo Huan 
Published: October 2022

AbstractEpidemiological investigations implied that mitochondrial DNA copy number (mtDNAcn) variations could trigger predisposition to multiple cancers, but evidence regarding gastrointestinal cancers (GICs) was still uncertain. We conducted a case‐cohort study within the prospective Dongfeng‐Tongji cohort, including incident cases of colorectal cancer (CRC, n = 278), gastric cancer (GC, n = 138), and esophageal cancer (EC, n = 72) as well as a random subcohort (n = 1173), who were followed up from baseline to the end of 2018. We determined baseline blood mtDNAcn and associations of mtDNAcn with the GICs risks were estimated by using weighted Cox proportional hazards models. Significant U‐shaped associations were observed between mtDNAcn and GICs risks. Compared to subjects within the second quartile (Q2) mtDNAcn subgroup, those within the 1st (Q1), 3rd (Q3), and 4th (Q4) quartile subgroups showed increased risks of CRC (hazard ratio [HR] [95% confidence interval, CI] = 2.27 [1.47–3.52], 1.65 [1.04–2.62], and 2.81 [1.85–4.28], respectively) and total GICs (HR [95%CI] = 1.84 [1.30–2.60], 1.47 [1.03–2.10], and 2.51 [1.82–3.47], respectively], and those within Q4 subgroup presented elevated GC and EC risks (HR [95% CI] = 2.16 [1.31–3.54] and 2.38 [1.13–5.02], respectively). Similar associations of mtDNAcn with CRC and total GICs risks remained in stratified analyzes by age, gender, smoking, and drinking status. This prospective case‐cohort study showed U‐shaped associations between mtDNAcn and GICs risks, but further research works are needed to uncover underlying biological mechanisms.
Research and analysis of voids in semiconductor laser diode packaging reflow soldering
Authors: Xu Peidong , Qian Yang , Wang Bin , Wang Yong , Yue Yuxin , Teng Yunjie , Wang Xiantao 
Published: October 2022

AbstractThe causes of voids in the soldering layer during vacuum reflow soldering of semiconductor laser devices are investigated, as are the movement and change laws of bubbles in the voids under different reflow chamber settings. An ultrasonic scanner is used to test and experiment with a series of 1064 nm wavelength semiconductor lasers. A technique for detecting the void rate based on the wavelength difference is proposed based on the association between the device wavelength, junction temperature, and voids. The average void rate error when comparing measured and calculated values is just 1.5%, demonstrating the validity of this estimation technique for defining the void rate of the device and providing a theoretical and practical reference to analyze the void rate of the device.