bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of a molten iron scheduling problem with uncertain processing time using variable neighborhood search algorithm
Authors: Liu Linyu , Chang Zhiqi , Song Shiji 
Published: May 2022

AbstractPunctuality of the steel-making scheduling is important to save steel production costs, but the processing time of the pretreatment process, which connects the iron- and steel-making stages, is usually uncertain. This paper presents a distributionally robust iron-steel allocation (DRISA) model to obtain a robust scheduling plan, where the distribution of the pretreatment time vector is assumed to belong to an ambiguity set which contains all the distributions with given first and second moments. This model aims to minimize the production objective by determining the iron-steel allocation and the completion time of each charge, while the constraints should hold with a certain probability under the worst-case distribution. To solve problems in large-scale efficiently, a variable neighborhood algorithm is developed to obtain a near-optimal solution in a short time. Experiments based on actual production data demonstrate its efficiency. Results also show the robustness of the DRISA model, i.e., the adjustment and delay of the robust schedule derived from the DRISA model are less than the nominal one.
Effects of the application of different improved materials on reclaimed soil structure and maize yield of Hollow Village in Loess Area
Authors: Liu Zhe , Zhang Yang , Sun Zenghui , Sun Yingying , Wang Huanyuan , Zhang Ruiqing 
Published: May 2022

AbstractIn order to solve the soil problem of poor structure and low fertility after the abandoned homestead reclamation of Hollow Village in Loess Area and to improve the quality of the reclaimed soil in Hollow Village, a five-year field experiment was conducted here. In this experiment, the following seven treatments were applied: no modified material (CK), maturing agent (TM), fly ash (TF), organic fertilizer (TO), maturing agent + fly ash (TMF), maturing agent + organic fertilizer (TMO) and fly ash + organic fertilizer (TFO), and the effects of different improved materials on soil properties and crop yield were studied. The results showed that: soil organic matter (SOM) and total nitrogen contents increased significantly after the application of different improved materials, which promoted the cementation and aggregation of water-stable microaggregates (< 0.25 mm), and the water-stable macroaggregates showed an increasing trend. In the 0–0.15 m soil layer, the proportion of water-stable macroaggregates under TM, TF, TO, TMF, TMO, and TFO treatment increased by 328.2%, 130.0%, 87.8%, 81.1%, 36.7%, and 12.2% compared with CK, respectively. Meanwhile, TF, TO, TMF, TMO, TFO treatments significantly increased the mean weight diameter (MWD) and geometric mean diameter (GMD) values, reduced soil bulk density, the stable aggregate index (ELT) and fractal dimension (D) values (P < 0.05), and the stability of soil structure and the capacity of soil moisture retention has been significantly improved. The SOM content had a significant positive correlation with MWD, GMD, and > 2 mm water-stable aggregates and a significant negative correlation with the ELT, D, and water-stable microaggregates. In particular, the organic–inorganic coupling treatment of TFO showed the highest SOM content, soil moisture content, water-stable macroaggregates and maize yield, which was the most appropriate amendment for improving the reclaimed soil structure and fertility of Hollow Village in Loess Area.
Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism
Authors: Espinosa-Salinas Isabel , Colmenarejo Gonzalo , Fernández-Díaz Cristina M. , Gómez de Cedrón Marta , Martinez J. Alfredo , Reglero Guillermo , Ramírez de Molina Ana 
Published: May 2022

AbstractThe pandemic burden caused by the SARS-CoV-2 coronavirus constitutes a global public health emergency. Increasing understanding about predisposing factors to infection and severity is now a priority. Genetic, metabolic, and environmental factors can play a crucial role in the course and clinical outcome of COVID-19. We aimed to investigate the putative relationship between genetic factors associated to obesity, metabolism and lifestyle, and the presence and severity of SARS-CoV-2 infection. A total of 249 volunteers (178 women and 71 men, with mean and ± SD age of 49 ± 11 years) characterized for dietary, lifestyle habits and anthropometry, were studied for presence and severity of COVID-19 infection, and genotyped for 26 genetic variants related to obesity, lipid profile, inflammation, and biorhythm patterns. A statistically significant association was found concerning a protective effect of APOE rs7412 against SARS-CoV-2 infection (p = 0.039; OR 0.216; CI 0.084, 0.557) after correction for multiple comparisons. This protective effect was also ascribed to the APOɛ2 allele (p = 0.001; OR 0.207; CI 0.0796, 0.538). The genetic variant rs7412 resulting in ApoE2, genetic determinant of lipid and lipoprotein levels, could play a significant role protecting against SARS-CoV-2 infection.
Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish
Authors: Shibata Takeaki , Kawana Hiroki , Nishino Yuri , Ito Yoshiko , Sato Hiroyasu , Onishi Hirofumi , Kano Kuniyuki , Inoue Asuka , Taketomi Yoshitaka , Murakami Makoto , Kofuji Satoshi , Nishina Hiroshi , Miyazawa Atsuo , Kono Nozomu , Aoki Junken 
Published: May 2022

AbstractPhospholipids in the membrane consist of diverse pairs of fatty acids bound to a glycerol backbone. The biological significance of the diversity, however, remains mostly unclear. Part of this diversity is due to lysophospholipid acyltransferases (LPLATs), which introduce a fatty acid into lysophospholipids. The human genome has 14 LPLATs and most of them are highly conserved in vertebrates. Here, we analyzed the function of one of these enzymes, lysophosphatidylglycerol acyltransferase 1 (Lpgat1), in zebrafish. We found that the reproduction of heterozygous (lpgat1+/−) male mutants was abnormal. Crosses between heterozygous males and wild-type females produced many eggs with no obvious cleavage, whereas eggs produced by crosses between heterozygous females and wild-type males cleaved normally. Consistent with this, spermatozoa from heterozygous males had reduced motility and abnormal morphology. We also found that the occurrence of lpgat1 homozygous (lpgat1−/−) mutants was far lower than expected. In addition, downregulation of lpgat1 by morpholino antisense oligonucleotides resulted in severe developmental defects. Lipidomic analysis revealed that selective phospholipid species with stearic acid and docosahexaenoic acid were reduced in homozygous larvae and spermatozoa from heterozygotes. These results suggest that the specific phospholipid molecular species produced by Lpgat1 have an essential role in sperm fertilization and in embryonic development.
Gap coupled symmetric split ring resonator based near zero index ENG metamaterial for gain improvement of monopole antenna
Authors: Moniruzzaman Md. , Islam Mohammad Tariqul , Samsuzzaman Md. , M M. Salaheldeen , Sahar Norsuzlin Mohd , Al-Bawri Samir Salem , Almalki Sami H. A. , Alsaif Haitham , Islam Md. Shabiul 
Published: May 2022

AbstractIn this article, a symmetric split ring resonator (SRR) based metamaterial (MTM) is presented that exhibits three resonances of transmission coefficient (S21) covering S, C, and X-bands with epsilon negative (ENG) and near zero index properties. The proposed MTM is designed on an FR4 substrate with the copper resonator at one side formed with two square rings and one circular split ring. The two square rings are coupled together around the split gap of the outer ring, whereas two split semicircles are also coupled together near the split gaps. Thus, gap coupled symmetric SRR is formed, which helps to obtain resonances at 2.78 GHz, 7.7 GHz and 10.16 GHz with desired properties of the MTM unit cell. The MTM unit cell's symmetric nature helps reduce the mutual coupling effect among the array elements. Thus, different array of unit cells provides a similar response to the unit cell compared with numerical simulation performed in CST microwave studio and validated by measurement. The equivalent circuit is modelled for the proposed MTM unit cell in Advanced Design System (ADS) software, and circuit validation is accomplished by comparing S21 obtained in ADS with the same of CST. The effective medium ratio (EMR) of 10.7 indicates the compactness of the proposed MTM. A test antenna is designed to observe the effect of the MTM over it. Numerical analysis shows that the proposed MTM have an impact on the antenna when it is used as the superstrate and helps to increase the gain of the antenna by 95% with increased directivity. Thus, compact size, high EMR, negative permittivity, near zero permeability and refractive index makes this MTM suitable for S, C and X band applications, especially for antenna gain with directivity enhancement.
A systems approach discovers the role and characteristics of seven LysR type transcription factors in Escherichia coli
Authors: Rodionova Irina A. , Gao Ye , Monk Jonathan , Hefner Ying , Wong Nicholas , Szubin Richard , Lim Hyun Gyu , Rodionov Dmitry A. , Zhang Zhongge , Saier Milton H. , Palsson Bernhard O. 
Published: May 2022

AbstractAlthoughEscherichia coliK-12 strains represent perhaps the best known model bacteria, we do not know the identity or functions of all of their transcription factors (TFs). It is now possible to systematically discover the physiological function of TFs inE. coliBW25113 using a set of synergistic methods; including ChIP-exo, growth phenotyping, conserved gene clustering, and transcriptome analysis. Among 47 LysR-type TFs (LTFs) found on theE. coliK-12 genome, many regulate nitrogen source utilization or amino acid metabolism. However, 19 LTFs remain unknown. In this study, we elucidated the regulation of seven of these 19 LTFs: YbdO, YbeF, YcaN, YbhD, YgfI, YiaU, YneJ. We show that: (1) YbdO (tentatively re-named CitR) regulation has an effect on bacterial growth at low pH with citrate supplementation. CitR is a repressor of theybdNMoperon and is implicated in the regulation of citrate lyase genes (citCDEFG); (2) YgfI (tentatively re-named DhfA) activates thedhaKLMoperon that encodes the phosphotransferase system, DhfA is involved in formate, glycerol and dihydroxyacetone utilization; (3) YiaU (tentatively re-named LpsR) regulates theyiaTgene encoding an outer membrane protein, andwaaPSBOJYZUoperon is also important in determining cell density at the stationary phase and resistance to oxacillin microaerobically; (4) YneJ, re-named here as PtrR, directly regulates the expression of the succinate-semialdehyde dehydrogenase, Sad (also known as YneI), and is a predicted regulator offnrS(a small RNA molecule).PtrR is important for bacterial growth in the presence ofl-glutamate and putrescine as nitrogen/energy sources; and (5) YbhD and YcaN regulate adjacent y-genes on the genome. We have thus established the functions for four LTFs and identified the target genes for three LTFs.
Identification of an elusive spliceogenic MYBPC3 variant in an otherwise genotype-negative hypertrophic cardiomyopathy pedigree
Authors: Torrado Mario , Maneiro Emilia , Lamounier Junior Arsonval , Fernández-Burriel Miguel , Sánchez Giralt Sara , Martínez-Carapeto Ana , Cazón Laura , Santiago Elisa , Ochoa Juan Pablo , McKenna William J. , Santomé Luis , Monserrat Lorenzo 
Published: May 2022

AbstractThe finding of a genotype-negative hypertrophic cardiomyopathy (HCM) pedigree with several affected members indicating a familial origin of the disease has driven this study to discover causative gene variants. Genetic testing of the proband and subsequent family screening revealed the presence of a rare variant in the MYBPC3 gene, c.3331−26T>G in intron 30, with evidence supporting cosegregation with the disease in the family. An analysis of potential splice-altering activity using several splicing algorithms consistently yielded low scores. Minigene expression analysis at the mRNA and protein levels revealed that c.3331−26T>G is a spliceogenic variant with major splice-altering activity leading to undetectable levels of properly spliced transcripts or the corresponding protein. Minigene and patient mRNA analyses indicated that this variant induces complete and partial retention of intron 30, which was expected to lead to haploinsufficiency in carrier patients. As most spliceogenic MYBPC3 variants, c.3331−26T>G appears to be non-recurrent, since it was identified in only two additional unrelated probands in our large HCM cohort. In fact, the frequency analysis of 46 known splice-altering MYBPC3 intronic nucleotide substitutions in our HCM cohort revealed 9 recurrent and 16 non-recurrent variants present in a few probands (≤ 4), while 21 were not detected. The identification of non-recurrent elusive MYBPC3 spliceogenic variants that escape detection by in silico algorithms represents a challenge for genetic diagnosis of HCM and contributes to solving a fraction of genotype-negative HCM cases.
Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion
Authors: Martchenko Alexandre , Biancolin Andrew D. , Martchenko Sarah E. , Brubaker Patricia L. 
Published: May 2022

AbstractThe incretin hormone glucagon-like peptide-1 (GLP-1) is secreted by the intestinal L cell in response to nutrient intake. However, GLP-1 secretion also follows a circadian rhythm which is disrupted by the saturated fatty acid palmitate in vitro and high-fat diet (HFD) feeding in vivo. The flavonoid nobiletin is a clock enhancer which improves metabolic homeostasis. Therefore, the aim of this study was to elucidate whether and how nobiletin mitigates the negative effects of palmitate and HFD-feeding on rhythmic GLP-1 release. Pre-treatment of murine GLUTag L cells with palmitate dampened the GLP-1 secretory response at the normal peak of secretion, while nobiletin co-treatment restored GLP-1 secretion and upregulated the ‘metabolic pathway’ transcriptome. Mice fed a HFD also lost their GLP-1 secretory rhythm in association with markedly increased GLP-1 levels and upregulation of L cell transcriptional pathways related to ‘sensing’ and ‘transducing’ cellular stimuli at the normal peak of GLP-1 release. Nobiletin co-administration reduced GLP-1 levels to more physiological levels and upregulated L cell ‘oxidative metabolism’ transcriptional pathways. Furthermore, nobiletin improved colonic microbial 16S rRNA gene diversity and reduced the levels of Proteobacteria in HFD-fed mice. Collectively, this study establishes that nobiletin improves the normal rhythm in GLP-1 secretion following fat-induced disruption.
Persistence versus dynamical seasonal forecasts of cereal crop yields
Authors: Bento Virgílio A. , Russo Ana , Dutra Emanuel , Ribeiro Andreia F. S. , Gouveia Célia M. , Trigo Ricardo M. 
Published: May 2022

AbstractClimate change is expected to have impacts on the balance of global food trade networks and food security. Thus, seasonal forecasts of precipitation and temperature are an essential tool for stakeholders to make timely choices regarding the strategies required to maximize their expected cereal yield outcomes. The availability of state-of-the-art seasonal forecasts such as the European Centre for Medium-Range Weather Forecasts (ECMWF) system 5 (SEAS5) may be an asset to help decision making. However, uncertainties and reduced skill may hamper the use of seasonal forecasts in several applications. Hence, in this work, we aim to understand the added value of such dynamical forecasts when compared to persistent anomalies of climate conditions used to predict the production of wheat and barley yields. With that in mind, empirical models relating annual wheat and barley yields in Spain to monthly values of precipitation and temperature are developed by taking advantage of ECMWF ERA5 reanalysis. Then, dynamical and persistence forecasts are issued at different lead times, and the skill of the subsequent forecasted yield is verified through probabilistic metrics. The results presented in this study demonstrate two different outcomes: (1) wheat and barley yield anomaly forecasts (dynamical and persistent) start to gain skill later in the season (typically from April onwards); and (2) the added value of using the SEAS5 forecast as an alternative to persistence ranges from 6 to 16%, with better results in the southern Spanish regions.
Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice
Authors: Jiang Zhou , Wang Juan , Imai Denise , Snider Tim , Klug Jenna , Mangalindan Ruby , Morton John , Zhu Lida , Salmon Adam B. , Wezeman Jackson , Hu Jiayi , Menon Vinal , Marka Nicholas , Neidernhofer Laura , Ladiges Warren 
Published: May 2022

AbstractPharmaceutical intervention of aging requires targeting multiple pathways, thus there is rationale to test combinations of drugs targeting different but overlapping processes. In order to determine if combining drugs shown to extend lifespan and healthy aging in mice would have greater impact than any individual drug, a cocktail diet containing 14 ppm rapamycin, 1000 ppm acarbose, and 1000 ppm phenylbutyrate was fed to 20-month-old C57BL/6 and HET3 4-way cross mice of both sexes for three months. Mice treated with the cocktail showed a sex and strain-dependent phenotype consistent with healthy aging including decreased body fat, improved cognition, increased strength and endurance, and decreased age-related pathology compared to mice treated with individual drugs or control. The severity of age-related lesions in heart, lungs, liver, and kidney was consistently decreased in mice treated with the cocktail compared to mice treated with individual drugs or control, suggesting an interactive advantage of the three drugs. This study shows that a combination of three drugs, each previously shown to enhance lifespan and health span in mice, is able to delay aging phenotypes in middle-aged mice more effectively than any individual drug in the cocktail over a 3-month treatment period.
Increased proinflammatory cytokines in tears correspond with conjunctival SARS-CoV-2 positivity in symptomatic COVID-19 patients
Authors: Niedźwiedź Anna , Kawa Miłosz , Pius-Sadowska Ewa , Kuligowska Agnieszka , Ziontkowska Alicja , Wrzałek Dawid , Wiącek Marta P. , Parczewski Miłosz , Ossowski Andrzej , Zielińska Grażyna , Safranow Krzysztof , Kozłowski Krzysztof , Machaliński Bogusław , Machalińska Anna 
Published: May 2022

AbstractTear fluid cytokine levels may serve as biomarkers of innate immune system response against SARS-CoV-2 infection. Therefore, our aim was to analyze panel of selected inflammatory cytokines in tears of COVID-19 patients in relation to presence of SARS-CoV-2 viral load in conjunctival secretions. In this study concentrations of TNF-α, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 p70, GM-CSF, and IFN-γ were determined by a magnetic bead assay in tear film collected from 232 symptomatic COVID-19 patients. SARS-CoV-2 ocular infection was confirmed based on positive conjunctival swab-based RT-PCR testing. Viral RNA in conjunctival sac was detected in 21 patients (9%). No relation between presence and the duration of ophthalmic symptoms and SARS-CoV-2 infection detected in conjunctival secretions was found. The tear film concentrations of IFN-γ, TNF-α, IL-5, IL-8 and GM-CSF were found to be significantly greater among patients with positive conjunctival swab results as compared to the group negative for SARS-CoV-2 in conjunctival sac. Our current data depict a group of inflammatory mediators in human tears, which may play a significant role in ocular pathology of SARS-CoV-2 conjunctival infection.
Machine learning-based prediction of relapse in rheumatoid arthritis patients using data on ultrasound examination and blood test
Authors: Matsuo Hidemasa , Kamada Mayumi , Imamura Akari , Shimizu Madoka , Inagaki Maiko , Tsuji Yuko , Hashimoto Motomu , Tanaka Masao , Ito Hiromu , Fujii Yasutomo 
Published: May 2022

AbstractRecent effective therapies enable most rheumatoid arthritis (RA) patients to achieve remission; however, some patients experience relapse. We aimed to predict relapse in RA patients through machine learning (ML) using data on ultrasound (US) examination and blood test. Overall, 210 patients with RA in remission at baseline were dichotomized into remission (n = 150) and relapse (n = 60) based on the disease activity at 2-year follow-up. Three ML classifiers [Logistic Regression, Random Forest, and extreme gradient boosting (XGBoost)] and data on 73 features (14 US examination data, 54 blood test data, and five data on patient information) at baseline were used for predicting relapse. The best performance was obtained using the XGBoost classifier (area under the receiver operator characteristic curve (AUC) = 0.747), compared with Random Forest and Logistic Regression (AUC = 0.719 and 0.701, respectively). In the XGBoost classifier prediction, ten important features, including wrist/metatarsophalangeal superb microvascular imaging scores, were selected using the recursive feature elimination method. The performance was superior to that predicted by researcher-selected features, which are conventional prognostic markers. These results suggest that ML can provide an accurate prediction of relapse in RA patients, and the use of predictive algorithms may facilitate personalized treatment options.
Electron liquid state in the spin-$$\frac{1}{2}$$ anisotropic Kondo lattice
Authors: Karnaukhov Igor N. 
Published: May 2022

AbstractIn the framework of the mean field approach, we provide analytical and numerical solution of the spin-$$\frac{1}{2}$$

1
2

anisotropic Kondo lattice for arbitrary dimension at half filling. Nontrivial solution for the amplitude of the field opens a gap in the fermion spectrum of an electron liquid in which local moments on the lattice sites are realized. The ground state in the insulator state is determined by a static $${\mathbb {Z}}_2$$

Z
2

field of local moments, which forms the lattice with a double cell, conduction electrons move in this field. Due to hybridization between electron states a large Fermi surface is formed in the Kondo lattice. A gap in the quasi-particle spectrum is calculated depending on the magnitudes of exchange integrals for the simple lattices with different dimension. The proposed approach is also valid for describing the Kondo lattice with weak anisotropy of the exchange interaction, which makes it possible to study the behavior of the spin-$$\frac{1}{2}$$

1
2

Kondo lattice with an isotropic exchange interaction.
Allergic rhinitis is associated with thromboembolic disease in pregnancy
Authors: Wu Chia-Ta , Tsao Chien-Han , Chen Kuan-Ting , Lee Yu-Tzu , Ku Min-Sho 
Published: May 2022

AbstractFinding the risk factors for thromboembolic (TE) disease and preventing its development in pregnant women is important. Allergic rhinitis (AR) is a common chronic disease. We aim to find if AR is a risk factor. From 2004 to 2011, 55,057 pregnant women were recruited from a Taiwan database. They were grouped into AR and non-AR groups. The rate of TE and venous complications during pregnancy and 60 days after childbirth were compared between non-AR and the AR group. Those with AR diagnosed both before and after childbirth, meaning AR was not changed during pregnancy, the rates of TE (OR 2.64) and venous complications (OR 1.35) were higher compared to non-AR subjects. In those who underwent cesarean delivery, the rate was also higher in group 3 (OR 4.14). Those with AR before childbirth, without after, meaning AR was well controlled during pregnancy, the rate of TE was not higher than that of the non-AR subjects. Pregnant women with AR have an increased rate of TE. An increased rate of venous complications in these subjects might explain the increase in TE. If AR is well controlled during pregnancy, the rate of TE does not appear to increase.