bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurse practitioner integration: Conceptual development to enhance application in policy and research
Authors: Porat-Dahlerbruch Joshua , Poghosyan Lusine , Blumenthal Nancy , Ratz Shoshana , Ellen Moriah E. 
Published: July 2022

ABSTRACT

Background:
Nurse practitioners (NPs) have been introduced across the world to improve care quality and solve provider shortages. Realizing these benefits relies on their successful integration into health care systems. Although NP integration has been discussed extensively, the concept is defined inconsistently. Literature, therefore, cannot be synthesized to create policy recommendations for management and policymakers to plan for and advance NP integration.

Objectives:
To describe and define NP integration and enhance its applicability in research and policy.

Data Sources:
A modified Walker and Avant concept analysis was used to develop a conceptual model of NP integration. Data were extracted and synthesized from 78 sources referencing the concept.

Conclusions:
Nurse practitioner integration was operationally defined as the multilevel process of incorporating NPs into the health care system so that NPs can practice to their full scope, education, and training and contribute to patient, system, and population needs. The attributes of NP integration are: 1) achievable goal; 2) process; 3) introduction of the role; 4) incorporation into organizational care models; 5) challenging traditional ideologies; 6) ability to function; 7) provide high-quality care; and 8) improve outcomes, sustainability, and health system transformation. Seventeen facilitators/barriers affecting NP integration were identified. Three health care system levels at which integration occurs were identified—macro, meso, and micro.

Implications for Practice:
Findings will inform managers, policymakers, and stakeholders about NP integration to aid in planning and policy development. Results can be used to inform research on barriers and facilitators to NP integration.
From Mushrooms to Myolysis
Authors: Suleiman Mariella , Basu Arnabh , Belal Sameen , Jacob Theresa 
Published: July 2022

Abstract
The involvement of certain recreational drugs, namely, hallucinogens, in the development of hyperactive syndromes is well known, but not well studied. In this report, we expand on this relationship by documenting the development of substance-induced psychosis in a young patient who used a large amount of psilocybin and developed symptoms of a first psychotic and manic episode, complicated by violent behavior and rhabdomyolysis. We further evaluate the association between psilocybin use and rhabdomyolysis and explore this understudied phenomenon and differentiate it from the diagnoses of other hyperactive syndromes seen in psychiatry. This case exemplifies the need for increased vigilance in psilocybin microdosing therapy and for physicians to be mindful of how each patient responds to its use to prevent life-threatening hyperactive syndromes in its wake.
Relationships Between Multiple Dimensions of Insight and Neurocognition, Metacognition, and Social Cognition
Authors: Gan Jun , Fu Hong , Zhu Xiongzhao 
Published: July 2022

Abstract
Insight is a complex and multidimensional concept, and has a complex relationship with cognition. A meta-analysis of 102 studies of 9396 patients was conducted to determine the magnitude of the relationship between insight and neurocognition, higher-order cognition in multiple mental disorders. Insight has been found moderately related to higher-order cognition, but only weakly related to neurocognition. The different relationship has been found between the dimensions of insight and higher-order cognition. Almost none of the correlational coefficients of insight and cognitive domains were found to differ significantly among the different diagnostic groups. In conclusion, insight may be essentially related to higher-order cognition, but not to neurocognition. The orientation and expression of different dimensions of insight might be different, and the relationship of insight and cognition might not be explained by specific diagnosis.
Fibroids and Fertility: A Comparison of Myomectomy and Uterine Artery Embolization on Fertility and Reproductive Outcomes
Authors: Zanolli Nicole C. , Bishop Katherine C. , Kuller Jeffrey A. , Price Thomas M. , Harris Benjamin S. 
Published: July 2022

Importance
Leiomyomata, or fibroids, are a common gynecological problem affecting many women of reproductive age. Historically, myomectomy is offered to women with symptomatic fibroids who desire to preserve fertility. More recently, uterine artery embolization (UAE) has been explored as another fertility-sparing option.

Objective
This review aims to provide an in-depth summary of the effects on fertility and reproductive outcomes following myomectomy and UAE for the treatment of symptomatic fibroids.

Evidence Acquisition
Articles were obtained from PubMed using search terms myomectomy, uterine artery embolization, and fertility, as well as American Society of Reproductive Medicine practice committee reports. References from identified sources were searched to allow for thorough review.

Results
While myomectomy and UAE are both fertility-sparing options for women with fibroids, reproductive outcomes following myomectomy are superior to UAE with higher rates of clinical pregnancy and live births and lower rates of spontaneous abortion, abnormal placentation, preterm labor, and malpresentation.

Conclusions
Myomectomy should be offered to women with symptomatic submucosal or cavity-distorting fibroids who have a strong desire for a future pregnancy. For women who are not appropriate surgical candidates, UAE can be offered, although detrimental effects on future fertility should be disclosed.

Relevance
A thorough understanding of the efficacy of both myomectomy and UAE, as well as their impact on future fertility, allows for improved counseling when deciding the optimal intervention for women with fibroids who desire future fertility.

Target Audience
Obstetricians and gynecologists, family physicians

Learning Objectives
After completing this activity, the learner should be better able to describe the pathophysiology and clinical presentation of fibroids, with an emphasis on their impact on fertility; compare the indications, procedural techniques, and outcomes following myomectomy and UAE; and explain fertility and pregnancy outcomes following both myomectomy and UAE.
Biofilm Production by Uropathogens in Postmenopausal Women With Recurrent and Isolated Urinary Tract Infection
Authors: Falk Kerac N. , Satola Sarah W. , Chassagne François , Northington Gina M. , Quave Cassandra L. 
Published: July 2022

(Abstracted from Female Pelvic Med Reconstr Surg 2022;28:e127–e132)
With 50% to 70% of women reporting a urinary tract infection (UTI) at some point in their lives, the diagnosis and treatment of this condition are common. Recurrent UTI occurs in approximately 20% to 30% of women, and estimated annual total health care costs of UTIs reside around $2.3 billion.
Implementation of a Revised Classification for Intrapartum Fetal Heart Rate Monitoring and Association to Birth Outcome: A National Cohort Study
Authors: Jonsson Maria , Söderling Jonas , Ladfors Lars , Nordström Lennart , Nilsson Marianne , Algovik Michael , Norman Mikael , Holzmann Malin 
Published: July 2022

(Abstracted from Acta Obstet Gynecol Scand 2022;101:183–192)
Electronic fetal monitoring (EFM) is an important tool for detecting fetal hypoxia before the development of adverse neonatal outcomes. Although EFM is highly sensitive, it also has low specificity.
Can Hysterosalpingo-Foam Sonography Replace Hysterosalpingography as First-Choice Tubal Patency Test? A Randomized Non-inferiority Trial
Authors: van Welie Nienke , van Rijswijk Joukje , Dreyer Kim , van Hooff Machiel H. A. , de Bruin Jan Peter , Verhoeve Harold R. , Mol Femke , van Baal Wilhelmina M. , Traas Maaike A. F. , van Peperstraten Arno M. , Manger Arentje P. , Gianotten Judith , de Koning Cornelia H. , Koning Aafke M. H. , Bayram Neriman , van der Ham David P. , Vrouenraets Francisca P. J. M. , Kalafusova Michaela , van de Laar Bob I. G. , Kaijser Jeroen , Lambeek Arjon F. , Meijer Wouter J. , Broekmans Frank J. M. , Valkenburg Olivier , van der Voet Lucy F. , van Disseldorp Jeroen , Lambers Marieke J. , Tros Rachel , Lambalk Cornelis B. , Stoker Jaap , van Wely Madelon , Bossuyt Patrick M. M. , Mol Ben Willem J. , Mijatovic Velja 
Published: July 2022

(Abstracted from Hum Reprod 2022;37:969–979)
A main cause of female infertility is tubal pathology, with 11% to 30% of cases resulting from previous surgery, infections (such as sexually transmitted diseases), or endometriosis. Hysterosalpingography (HSG) is considered as the first choice for a tubal patency test during fertility workup, but the more patient-friendly hysterosalpingo-contrast sonography option has also been introduced.
Factors Affecting Optic Nerve Damage in Le Fort III Osteotomy: A Retrospective Study
Authors: Noto Mariko , Sakahara Daisuke , Sakamoto Yoshiaki , Imai Keisuke 
Published: July 2022

The causes of visual impairment following Le Fort osteotomy for syndromic craniosynostosis have not been completely elucidated. The authors investigated the potential causes and means of prevention of optic nerve damage, with particular emphasis on intraoperative blood transfusion volume and operating time.
This retrospective study evaluated patients who underwent Le Fort III osteotomy for syndromic craniosynostosis between 2000 and 2020. Data on pupillary reflex, pupil size, operating time, blood transfusion, age at time of surgery, sex, and syndrome type were obtained from medical records. Univariate analysis and multivariate analysis with the level of statistical significance set at P<0.05.
For the 86 patients included, the mean values of operating time, amount of blood transfusion based on body weight, amount of blood transfusion per body weight per hour, and age were 6.0 hours (range: 3.5–12.3 h), 30.5 mL/kg (range: 0–322 mL/kg), 5.14 mL/kg/h (range: 0–35.7 mL/kg/h), and 10.0 years (range: 4–38 y), respectively. Crouzon, Apert, and Pfeiffer syndromes were observed in 49, 29, and 8 patients, respectively. Abnormal pupillary findings were observed in 27 patients of whom 25 showed no abnormalities in subsequent visual function and 2 developed blindness. Abnormal pupillary findings correlated with the amount of blood transfused per body weight (P=0.0082) and amount of blood transfused per body weight per hour (P=0.0052).
As demonstrated in this study, increased intraoperative bleeding and amount of blood transfused were associated with optic nerve damage, particularly during acute bleeding. Prompt inspection of the pupils following surgery is therefore warranted.
Predicting Changes in Cephalic Index Following Spring-mediated Cranioplasty for Nonsyndromic Sagittal Craniosynostosis: A Stepwise and Machine Learning Algorithm Approach
Authors: Villavisanis Dillan F. , Shakir Sameer , Zhao Chao , Cho Daniel Y. , Barrero Carlos , Blum Jessica D. , Swanson Jordan W. , Bartlett Scott P. , Tucker Alexander M. , Taylor Jesse A. 
Published: July 2022

Background:
Spring-mediated cranioplasty (SMC) is an increasingly utilized technique to treat patients with nonsyndromic sagittal craniosynostosis, but variables impacting outcomes are incompletely understood. The purpose of this study was to determine variables most predictive of outcomes following SMC, primarily changes in cephalic index (CI).

Methods:
Patients with nonsyndromic sagittal craniosynostosis undergoing SMC at our institution between 2014 and 2021 were included. Cephalic index was measured from patient computed tomography scans, x-rays, or by caliper-based methods. Parietal bone thickness was determined from patient preoperative computed tomography. Stepwise multiple regression analysis, least absolute shrinkage and selection operator, and random forest machine learning methods were used to determine variables most predictive of changes in CI.

Results:
One hundred twenty-four patients were included. Stepwise multiple regression analysis identified duration of spring placement (P=0.007), anterior spring force (P=0.034), and anterior spring length (P=0.043) as statistically significant predictors for changes in CI. Least absolute shrinkage and selection operator analysis identified maximum spring force (β=0.035), anterior spring length (β=0.005), posterior spring length (β=0.004), and duration of spring placement (β=0.0008) as the most predictive variables for changes in CI. Random forest machine learning identified variables with greatest increase in mean squared error as maximum spring force (0.0101), anterior spring length (0.0090), and posterior spring length (0.0056).

Conclusions:
Maximum and total spring forces, anterior and posterior spring lengths, and duration of spring placement were the most predictive variables for changes in CI following SMC. Age at surgery and other demographic variables were inferior predictors in these models.
Evaluation of experiences and attitudes of patients towards patient portal enabled access to their health information or medical records – A Qualitative Study
Authors: Kuppanda Preksha Machaiya , Jenkins Judy 
Published: July 2022

AbstractThe demand for patient centred care and patient engagement in their healthcare has driven patient portal introduction. The widespread adoption and use of patient portals, however, has been a rather slow process in the United Kingdom (UK). Hence, a limited number of studies have explored patient perceptions and experiences of general portal use which forms a foundation for successful implementation of a portal. This study, therefore, focuses on the experiences and attitudes of patients regarding use of patient portals and access to their health information. It further explores various factors perceived by patients that may influence portal use and uptake. These patient experiences were gathered through semi-structured interviews of 13 participants and the data collected was subjected to analysis using the grounded theory approach. The overall findings from this study highlights positive patient perceptions of portal use. Nevertheless, it demonstrates various areas of improvement essential to ensure successful implementation and acceptance of patient portals in the future.Authors summaryPatient portals have become a globally popular tool used in the healthcare sector due to its potential to increase patient engagement which is considered essential to provide patient centred care. Similarly, the use of patient portals in the UK has increased, with different providers making this service available to patients. Patients are the key target users of patient portals, however, there is limited research that focuses on understanding patients’ perspective of using a patient portal and accessing their health information. The majority of the existing studies have either evaluated providers or healthcare professionals’ perspective of patient portal implementation or explored patient experiences of using patient portal tailored to cater individuals with specific health conditions. Therefore, our aim was to explore patients’ perception of patient portals and their experiences of accessing their health information or medical records through one. Our research has captured various factors that has influenced portal use among patients and the impact of health information access on patients and their care process. Additionally, it has identified scope for future development and discussed factors that could potentially improve patient portal implementation and drive portal use and uptake among patients.
Acceptability, willingness to use and preferred distribution models of oral-based HIV self-testing kits among key and priority populations enrolled in HIV pre-exposure prophylaxis clinics in central Uganda. A mixed-methods cross-sectional study
Authors: Junior Matovu John Bosco , Mayega Roy William , Nalubega Sylivia , Byakika-Tusiime Jayne 
Published: July 2022

AbstractKey Populations (KPs) and Priority Populations (PPs) taking Pre-Exposure Prophylaxis (PrEP) for HIV prevention require routine HIV testing every after three months. HIV self-testing could be an alternative testing approach for these population categories. We assessed the acceptability of oral-based HIV Self-Testing (HIVST) among Key and priority Populations taking PrEP in central Uganda. A mixed methods cross-sectional study was conducted on 367 key and priority populations attending Pre-Exposure Prophylaxis clinics in central Uganda, from May to August 2018. KPs and PPs were introduced to the Oraquick HIV self-testing kit as an option for HIV testing during their routine visit to the PrEP clinic. A demonstration of how to perform HIV self-testing was conducted using an Oraquick demonstration video and leaflet inserts after which, respondents were asked to choose between HIVST and the conventional facility blood-based HIV testing. Those willing to use the oral kit were asked to voluntarily consent, were provided with an Oraquick HIVST kit and were assisted to perform the test. Quantitative data were presented as proportions for each outcome variable. Thematic analysis was performed to explore factors that promote and inhibit HIVST. HIV self-testing acceptability; defined as the proportion of those who performed an HIVST test among those approached was 99.5% (365/367). Using an oral fluid-based kit “Oraquick” was reported to be free of pain, convenient, easy to use and time saving hence preferred over other HIV testing modalities. A multimodal approach to distributing HIV self-testing kits was suggested by respondents. Oral-based HIV self-testing is highly acceptable among key and priority populations taking Pre-Exposure Prophylaxis and can be adopted as an alternative to the conventional routine three monthly facility-based provider dependent HIV screening. Kits’ distribution may employ several models. Majority of key populations would afford the kits at a cost of not more than 1.4USD if not provided free of charge.
Health related quality of life of oral cancer patients who receive radiotherapy with or without chemotherapy in a tertiary referral centre in Sri Lanka- A prospective study
Authors: Kosgallana Shamini , Jayasekara Prasanna , Abeysinghe Prasad , Lalloo Ratilal 
Published: July 2022

AbstractPurposeTo assess the health-related quality of life (HRQOL) of oral cancer patients who receive radiotherapy (RT) with or without chemotherapy and the changes in HRQOL.Patients and MethodsA prospective study was conducted among oral cancer patients who receive RT with or without chemotherapy. Two European Organization for the Research and Treatment of Cancer Quality of Life Questionnaires: EORTC QLQ-C30 and EORTC QLQ-H&N35, were used to assess HRQOL before RT, during the last week of RT and three months after RT. High scores of symptom domains and items indicate low HRQOL and wise versa for functional and ‘Global health status’ domains.ResultsNinety oral cancer patients were included. The majority of the sample were males (88%) and 68% were aged 50-69. The median scores of all the domains and items in EORTC QLQ-H&N35 and symptom domains and items in EORTC QLQ-C30 were higher during the last week of RT compared to the baseline. The functional domains of EORTC QLQ-C30 showed the highest median values (100.0) at baseline but much less values (<66.7) during last week of RT. Except for ‘Appetite loss’ item, all the symptom domains and items scores were lower at three months after RT than the median scores during last week of RT. Statistically significant differences were observed in almost all the changes in HRQOL between three-time frames (p<0.05).ConclusionsHRQOL of oral cancer patients declined due to RT from baseline to the last week of RT and improved three months after RT from last week of RT but had not returned to the baseline level.
Nutrition and exercise diabetes knowledge and practices of family members of patients in rural areas of Limpopo Province, South Africa
Authors: Mphasha Mabitsela , Skaal Linda , Mothiba Tebogo 
Published: July 2022

AbstractFamily Members (FMs) offers basic assistance with meals and exercise, both of which are critical in diabetes control. Support from family has been linked to better outcomes. Family support, on the other hand, might lead to poor diabetes outcomes, especially when FMs lack information. Patients’ outcomes can be influenced by established family practices. As a result, the goal of this study is to determine diabetes FMs’ knowledge and practices in the areas of nutrition and exercise. On 200 FMs selected via convenient sampling from rural clinics in Senwabarwana, Limpopo Province, a quantitative approach and cross-sectional descriptive design were used. Close-ended questionnaires were used to collect data, which were then analyzed using Statistical Package for Social Sciences Software v27.0 and descriptive and inferential statistical analysis. Only 31% of participants had great overall knowledge, according to the findings, and only 9% had good practice. Over half of the participants (53%) believe that overweight diabetes patients should skip meals in order to lose weight, and 3.5% and 19%, respectively, are familiar with exercise prescriptions and glucose measurements. Only 35,5% of people eat breakfast every day, whereas the overwhelming majority (87,5%) exercise. The findings of this study show that patient’s FMs need to enhance their diet and exercise diabetes care knowledge and practices. To reduce diabetes prevalence and its detrimental impact on patients’ diabetes treatment, a combined strategy of community-based awareness campaigns and a family-centered approach is proposed, as well as behavior change intervention.
Optimal frequency of perinatal retinal waves is essential for the precise wiring of visual axons in non-image forming nuclei
Authors: Negueruela Santiago , Morenilla-Palao Cruz , Sala Salvador , Herrera Macarena , Coca Yaiza , López-Cascales Maria Teresa , Ordoño Patricia , Florez-Paz Danny , Gomis Ana , Herrera Eloísa 
Published: July 2022

ABSTRACTThe development of the visual system is an intricate and multi-step process involving the precise connection of retinal ganglion cell (RGC) axon terminals with their corresponding neurons in the visual nuclei of the brain. Upon reaching primary image-forming nuclei (IFN), such as the superior colliculus and the lateral geniculate nucleus, RGC axons undergo extensive arborization that refines over the first few postnatal weeks. The molecular mechanisms driving this activity-dependent remodeling process, which is influenced by spontaneous activity in the developing retina, are still not well understood. In this study, by manipulating the activity of RGCs in mice and analyzing their transcriptomic profiles before eye opening, we have identified gene programs involved in activity-dependent refinement. Furthermore, while RGC axons also target non-image forming nuclei (NIFN), the impact of spontaneous retinal activity on the development of these accessory nuclei, has not yet been elucidated. The analysis of visual terminals from mice with altered retinal activity revealed that spontaneous retinal waves occurring prior to visual experience also play a role in shaping the connectivity of the non-image forming circuit. Overall, these findings contribute to a deeper understanding of the mechanisms governing activity-dependent axon refinement during the establishment of the visual circuit.