bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathophysiological role of chemokine MIG/CXCL9 in the development of atopic dermatitis
Authors: Kibalina I. V. , Tsybikov N. N. , Fefelova E. V. , Sholokhov L. F. 
Published: May 2022

Background. In patients with atopic dermatitis, the persistence of microorganisms on the skin surface is high, which can enhance the expression of MIG/CXCL9, exacerbating inflammation and activating keratinocyte apoptosis, however, the dynamics of this chemokine in atopic dermatitis has not been studied.The aim. To study the concentration of chemokine MIG/CXCL9 in the dynamics of atopic dermatitis and determine its role in the pathogenesis of dermatosis.Materials and methods. The study included 80 patients aged 13 to 44 years with limited and widespread atopic dermatitis and 30 practically healthy volunteers. The therapy of patients, the collection of biological material were carried out in the Regional Dermatovenerologic Dispensary in Chita, laboratory tests were performed at the Chita State Medical Academy in the period from 2018 to 2020. The MIG/CXCL9 level was studied during exacerbation and remission of the disease in blood serum and skin exudate by flow cytofluorimetry using LEGENDplex Human Proinflammatory Chemokine Panel (BioLegend, USA). In healthy volunteers, skin exudate sampling was carried out by the “skin window” method. For statistical processing, the Microsoft Excel (Microsoft Corp., USA) application software package and SPSS Statistics 25.0 (IBM Corp., USA) were used.Results. The concentration of chemokine MIG/CXCL9 in the skin exudate is greater than in the blood serum. With a limited form of the disease in adolescents, the level of MIG/CXCL9 in the skin exudate is 8.1 times higher than the control values, with a common form – 9.3 times. In adults with advanced atopic dermatitis, the concentration of chemokine IL/CXCL9 in the skin exudate is 20.8 times higher than the values of the control group.Conclusion. In atopic dermatitis, the level of chemokine MIG/CXCL9 is higher in the cutaneous pathological process. In the pathogenesis of the disease, MIG/ CXCL9 inhibits collagen synthesis and promotes apoptosis of keratinocytes, followed by the formation of hyperreactivity of the skin, its dryness and peeling.
Аnalysis of the cytokine profile of blood serum and tumor supernatants in breast cancer
Authors: Gergenreter Yu. S. , Zakharova N. B. , Barulina M. A. , Maslyakov V. V. , Fedorov V. E. 
Published: May 2022

Background. A crucial role in the development of cancer is played by the tumor microenvironment (TM) – a microenvironment that is formed as a result of the interaction between the tumor tissue and macroorganism cells. The concentration of TM cytokines in the blood varies depending on the activity of the tumor and the presence of a metastatic process. It is advisable to study the existing mediator imbalance of TM, its characteristic features in the process of tumor development for the diagnosis and prognosis of the tumor process.The aim. To identify markers of tumor progression in the study of tissue and serum cytokines in women diagnosed with breast cancer.Materials and methods. The object of the study is blood serum cytokines and tumor supernatants (MCP-1, VEGF, TNF-α, IFN-γ, TGF-β1, G-CSF, GM-CSF). The study involved 80 patients with breast cancer aged 50–69 years and 26 practically healthy women aged 41 to 62 years. A standard examination of women was conducted; a cytokine profile study was conducted before the appointment of therapy. To study the cytokine profile at the tissue level, tumor biopsies (n = 30) and biopsies of unchanged breast tissue (n = 6) were incubated to determine the production of MCP-1, VEGF, TNF-α, IFN-γ, TGF-β1, G-CSF, GM-CSF.Results. There was a moderate positive correlation between the stage of the disease and the level of TGF-β1, MCP-1 blood serum, a weak one – with G-CSF. In the incubated tumor tissue, a high positive correlation of cytokines on the stage of the disease is observed in growth factors: VEGF (R = 0.79; p > 0.05) and TGF-β1 (R = 0.61; p > 0.05).Conclusion. The study revealed the characteristic features of the cytokine profile of blood serum and tumor tissue in breast cancer at local and widespread stages. The revealed differences in the level of cytokines should be used as additional diagnostic indicators of the degree of activity and prevalence of the tumor process.
Creative productivity of elderly scientists
Authors: Postavnev V. M. , Postavneva I. V. , Peskov V. P. , Dvoinin A. M. 
Published: May 2022

The article presents the results of studying the personality characteristics of elderly scientists who have maintained scientific productivity for a long time. The problem that has to be solved and has got a huge scientific and practical significance is to find the psychological preconditions for the peak achievements of scientists and to define the social and psychological factors that contribute to maintaining the high productivity of elderly scientists for a long time.The aim of the study is to determine the key personality traits of famous elderly scientists at the stages of their professional development.Research methods. The presented data were obtained using the research interview “Life Values and Life Path”, developed by V.S. Mukhina. Empirical material was collected in the course of interviewing famous Russian scientists of older age (from 65 to 94 years old), involved in research activities and making a significant contribution to the development of the humanities and technical sciences. When forming the sample, we followed the logic of V.S. Mukhina, who interviewed older scientists who are the founders and leaders of well-known scientific schools, who have a doctorate in science, the academic title of professor, membership in the academy of the Russian Academy of Sciences, Russian Academy of Medical Sciences or Russian Academy of Education and continue active scientific work. Data on the peak achievements of older scientists were taken from the scientometric databases of the Russian Science Citation Index and the Russian State Library.Results. The data representing the peak achievements of the elderly scientists were taken from the scientometric databases and interpreted according to the provisions of differential and acmeological analysis for professional activities of scientists. The analysis of interviews, autobiographical descriptions and peak achievements of the elderly scientists allowed to reveal that the peak achievement (acme) is the joint result of psychological preconditions (personal traits of scientists, physical conditions) and social conditions of professional activity (social status of a scientist, belonging to a scientific school, availability of organizational and financial resources). The several productive periods, which are called within the acmeology field as “micro-acme”, can be indicated in the scientific work of elderly scientists throughout the period of their scientific activity. At the same time, the peak achievements of scientists as a rule are spaced in time with an optimal combination of preconditions and conditions for scientific creativity.
Assessment of the quality of life of patients with achalasia of the cardia after videoendoscopic Heller cardiomyotomy with Dor fundoplication
Authors: Tseymakh E. A. , Gankov V. A. , Bagdasaryan G. I. , Andreasyan A. R. , Maslikova S. A. 
Published: May 2022

Background. The leading symptom of achalasia of cardia (AC) is dysphagia, along with other symptoms significantly affecting the quality of life of patients.The aim. Based on the results of questioning patients using special and general questionnaires and using special methods for studying the closing function of the cardia, to evaluate the quality of life of patients with stages 2–4 of AC after video-laparoscopic esophagocardiomyotomy according to Heller with anterior hemiasophagofundoplication according to Dor.Materials and methods. The basis of the work was the analysis of the results of esophagocardiomyotomy according to Heller with anterior hemiesophagofundoplication according to Dor in 106 patients with stages 2–4 of AC. The postoperative follow-up period averaged 2 ± 0.4 years. In the pre- and postoperative periods, the results of fluoroscopy of the esophagus and stomach, manometry of the esophagus and the esophageal-gastric junction were studied, and three questionnaires were used (Eckhardt scale, GIQLI questionnaire and SF-36).Results. Analysis of the data obtained showed that the clinical manifestations of the disease in the postoperative period decreased in all patients with stages 2–4 of AC, the results in patients with stage 2 were better than in patients with stages 3 and 4 (p < 0.05). The results of fluoroscopy of the esophagus and stomach, manometry of the esophagus and the esophagogastric junction showed improvement in the postoperative period in patients at all stages of the disease, the results of patients with stage 4 were worse compared with stages 2 and 3 (p < 0.05).Conclusion. Videoendoscopic esophagomyotomy according to Heller with anterior fundoplication according to Dor significantly reduces the severity of clinical manifestations of AC and improves the quality of life in patients with stages 2–4 of AC, as a result of which surgery should be recommended to patients already at stage 2 and organ-preserving surgery at stage 4 of the disease.
The recurrences of cervical cancer: Possibilities of molecular prediction
Authors: Ashrafyan L. A. , Belokrinitskaya T. E. , Sholokhov L. F. , Kayukova E. V. , Mudrov V. A. 
Published: May 2022

The incidence of recurrence of cervical cancer ranges from 10 to 40 %. The 5-year survival rate for patients with recurrent cervical cancer is about 5–15 % against the background of current drug therapy. Clinical and morphological characteristics of the tumor process are known, which are used as markers of an unfavorable prognosis for the development of cervical cancer recurrence. The search for molecular prognostic markers of the course of cervical cancer continues.The aim. To determine the level of immune cycle proteins in patients with cervical cancer 0–IV stages, depending on the occurrence of a relapse of the disease.Materials and research methods. A retrospective analysis of previously obtained results of a study on the local level of immune cycle proteins in patients with cervical cancer was performed. Three years after follow-up, 2 groups were formed: group 1 – patients treated for cervical cancer without signs of disease progression (n = 83); group 2 – patients with cervical cancer with local or systemic recurrence (n = 18). Used statistical methods: non-parametric methods of statistics using the Kruskal – Wallis test; ROC-analysis for significant values in order to calculate threshold values; determination of the quality of the identified predictive markers by calculating the sensitivity, specificity, accuracy.Results. Local initial threshold values have a predictive value for predicting the occurrence of cervical cancer recurrence: B7.2 < 10.7 pg/ml (Se = 0.87; Sp = 0.73; Ac = 0.76; AUC = 0.78), PD-L1 ≤ 5.1 pg/ml (Se = 0.87; Sp = 0.68; Ac = 0.71; AUC = 0.76), sCD27 ≥ 32.0 pg/ml (Se = 0.75; Sp = 0.78; Ac = 0.78; AUC = 0.75).Conclusion. Determination of local levels of B7.2, PD-L1, sCD27 in patients with cervical cancer before treatment can be used to predict the development of disease recurrence during 3 years of follow-up.
Comparison of quality of life in patients with primary postoperative and autoimmune hypothyreosis
Authors: Styazhkina S. N. , Chernyadeva E. V. , Chernyshova Т. E. , Surnina O. V. , Kolbina T. V. , Nabiullina Z. R. , Varlamova M. A. 
Published: May 2022

Background. Achieving a high level of quality of life is one of the priorities in the treatment of chronic diseases. Focusing on the quality of life, it is possible to optimally adjust the treatment plan for patients, influencing the link that suffers most in this pathology. Hypothyroidism is mainly formed as a result of surgery on the thyroid gland, or autoimmune thyroiditis, and at the same time is one of the most common endocrine diseases, is of great social importance due to the potentially adverse effect on most organs and systems, resulting in a decrease in quality of life.The aim. To analyze the impact of primary hypothyroidism (postoperative hypothyroidism and autoimmune thyroiditis) on the quality of life of patients.Materials and methods. During the study, a clinical, laboratory and psychological study of 78 women with uncompensated primary hypothyroidism was carried out: 40 women aged 32–76 years with postoperative hypothyroidism (main group) and 38 women aged 36–60 years with autoimmune thyroiditis (comparison group). The quality of life was judged by the indicators of the MOS SF-36 questionnaire.Conclusion. In the examined patients with primary hypothyroidism, an association between an increase in TSH levels and a decrease in all indicators of the quality of life was revealed. First, indicators of physical functioning, general health, role and emotional functioning worsened. The dependence of indicators on the MOS SF-36 scales with the age of patients, the duration of hypothyroidism, and the level of TSH was revealed. The quality of life in patients with postoperative hypothyroidism was significantly reduced compared to patients who had hypothyroidism due to autoimmune thyroiditis.
SUKU BANYAK BERNSTEIN DAN OPERATOR KANTOROVICH UNTUK BEBERAPA FUNGSI YANG TIDAK KONTINU
Authors: Gunadi Reinhart , Hakim Denny I. 
Published: May 2022

Teorema hampiran Weierstrass menyatakan bahwa setiap fungsi kontinu pada [0, 1] dapat dihampiri secara seragam oleh barisan suku banyak, salah satunya barisan suku banyakBernstein. Akan tetapi, kekonvergenan suku banyak Bernstein tidak dapat ditentukan secara umum untuk fungsi yang tidak kontinu. Oleh karena itu, hampiran untuk fungsi-fungsi yangtidak kontinu memerlukan perumuman dari suku banyak Bernstein, misalnya operator Kantorovich. Salah satu kelebihan operator Kantorovich adalah bahwa barisan suku banyak yangdibentuk oleh operator ini konvergen dalam ruang L1([0, 1]) untuk sebarang fungsi yang terintegralkan. Tujuan dari penelitian ini adalah memeriksa kekonvergenan barisan suku banyakBernstein dan operator Kantorovich untuk beberapa fungsi yang tidak kontinu seperti fungsi Dirichlet dan fungsi Thomae, khususnya kekonvergenan hampir di mana-mana dan dalamL1([0, 1]). Kedua mode kekonvergenan tersebut didemonstrasikan secara analitik dan numerik. Penelitian ini menunjukkan bahwa kekonvergenan barisan suku banyak Bernstein bergantung pada ketakkontinuan fungsi yang ditinjau. Fungsi yang tidak kontinu di mana-mana tidak konvergen dalam kedua mode kekonvergenan yang diperiksa, sementara fungsi yang kontinu hampir di mana-mana masih dapat konvergen. Di lain sisi, barisan suku banyak yang dibangun oleh operator Kantorovich senantiasa konvergen hampir di mana-mana dan dalam L1([0, 1]) untuk semua fungsi yang dikaji dalam penelitian ini .
DIMENSI METRIK LOKAL PADA GRAF FLOWER DAN GRAF GEAR KORONA GRAF LINTASAN
Authors: Ashim Salma Fauziyah , Kusmayadi Tri Atmojo , Martini Titin Sri 
Published: May 2022

Misal G merupakan graf terhubung dan sederhana dengan V (G) merupakan himpunan titik. Jarak dari dua titik u dan v pada graf G merupakan panjang lintasan terpendek diantara titik u dan titik v yang dinotasikan d(u, v). Himpunan W ⊂ V (G) dan v ∈ V (G). Jika W = {w1, w2, w3, ..., wn} maka representasi dari titik v terhadap W adalah n-pasang terurut, yaitu r(v|W ) = (d(v, w1), d(v, w2), d(v, w3), ..., d(v, wn)). Suatu himpunan W disebut sebagai himpunan pembeda lokal jika r(u|W ) ̸= r(v|W ) untuk setiap pasang titik u dan v yang saling bertetangga pada graf G. Jumlah anggota minimum dari himpunan pembeda lokal disebut basis metrik lokal dari graf G dan banyaknya anggota pada basis disebut dimensi metrik lokal dari graf G yang dinotasikan diml(G). Tujuan penelitian ini yaitu mampu menentukan dimensi metrik lokal pada graf flower d an g raf g ear k orona g raf l intasan. Diperoleh hasil penelitian bahwa dimensi metrik lokal pada graf flower yaitu diml(F l n) = 3 untuk n = 3, diml(F ln) = n − 2 untuk n ≥ 4. Sementara itu, dimensi metrik lokal pada graf gear korona graf lintasan yaitu diml(Gm ⊙ Pn) = 1 untuk m ≥ 3 dan n = 1, diml(Gm ⊙ Pn) = 2m + 1 untuk m ≥ 3 dan 2 ≤ n ≤ 5, diml(Gm ⊙ Pn) = (2m + 1)⌊n+2 ⌋ untuk m ≥ 3 dan n ≥ 6.
KOREPRESENTASI KOALJABAR F [G]
Authors: Hijriati Na’imah , Wijayanti Indah Emilia 
Published: May 2022

Abstrak. Diberikan grup berhingga G dan lapangan F . Aljabar grup F [G] merupakan suatu ring sekaligus merupakan ruang vektor atas F . Diketahui, jika ruang vektor V atas F merupakan modul atas aljabar grup F [G] maka selalu dapat dikonstruksi suatu representasi ring F [G] terhadap V , yakni suatu homomorfisma ring dari F [G] ke ring semua tranformasi linear pada V . Lebih lanjut, diketahui juga F [G] dan ring semua transformasi linear pada V merupakan koaljabar atas F . Berdasarkan hal ini, jika suatu ruang vektor atas F merupakan komodul atas F [G] maka muncul permasalahan apakah dapat dikonstruksi suatu homomorfisma koaljabar dari F [G] ke koajabar semua transformasi linear pada ruang vektor tersebut. Oleh karena itu, pada tulisan ini akan diberikan pengkonstruksian homomorfisma koajabar F [G] terhadap suatu ruang vektor atas F . Selanjutnya, homomorfisma koaljabar F [G] disebut korepresentasi koaljabar F [G] terhadap suatu ruang vektor atas F .
HUBUNGAN SIFAT BERSIH PADA RING, MODUL, KOMODUL DAN KOALJABAR
Authors: Puspita Nikken Prima , Wijayanti Indah Emilia , Surodjo Budi 
Published: May 2022

Diberikan ring komutatif R dengan elemen satuan. Ring R disebut bersih jika setiap elemennya dapat dinyatakan sebagai jumlahan elemen unit dan idempoten. Sebuah R-modul M disebut modul bersih jika ring endomorfisma dari M adalah ring bersih. Misalkan C adalah R-koaljabar yang bersifat koasosiatif dan kounital. Sebuah C-komodul M dikatakan bersih jika ring endomorfisma dari C-komodul M adalah ring bersih. Oleh karena setiap koaljabar merupakan komodul atas dirinya sendiri, koaljabar bersih didefinisikan sebagai kejadian khusus dari komodul bersih. Pada paper ini akan dilihat keterkaitan sifat bersih pada struktur ring, modul, koaljabar dan komodul.
KONTRAKSI PERTINGKATAN PADA PERTINGKATAN PAULI SL(N, C)
Authors: Saputra Reynald , Rachmaputri Gantina 
Published: May 2022

Abstrak. Aljabar Lie sl(n, C) merupakan salah satu jenis aljabar Lie klasik. Tujuan dari penelitian ini untuk melihat apa saja aljabar Lie lain yang dapat dihasilkan dari kontraksi pertingkatan aljabar Lie sl(n, C). Aljabar Lie yang diperoleh akan disebut sebagai solusi dari kontraksi pertingkatan. Secara khusus, akan ditinjau kasus pada nilai n = 3 dan pertingkatan yang ditinjau adalah pertingkatan Pauli. Pertingkatan Pauli pada sl(3, C) merupakan salah satu fine grading (pertingkatan yang terbaik) dari empat fine grading yang bisa dilakukan pada sl(3, C). Untuk kontraksi pertingkatan Pauli pada sl(3, C), terdapat 48 persamaan kontraksi yang dapat digunakan untuk memperoleh solusi dari kontraksi pertingkatan Pauli pada sl(3, C). Untuk menyelesaikan persamaan kontraksi tersebut, digunakan bantuan dari grup simetri pertingkatan Pauli sl(3, C). Di akhir, penulis memberikan sedikit hasil lain yaitu kasus ketika n = 2 dan n = 4 serta dekomposisi Levi pada kontraksi pertingkatan Pauli sl(3, C).
SEGITIGA TITIK CIRCUMCENTER PADA MODIFIKASI TEOREMA NAPOLEON
Authors: Hartati Yunisa Fadhilah , Mashadi Mashadi 
Published: May 2022

Tulisan ini membahas tentang segitiga titik circumcenter pada modifikasi teorema napoleon yaitu jika disetiap sisi bagian luar suatu segitiga asal dibangun masing-masing sebuah segitiga sama kaki dengan tingginya dua kali tinggi segitiga sama sisi. Titik-titik circumcenter dari tiga segitiga sama kaki bagian luar tersebut akan membentuk segitiga yang baru yang sesuai dengan segitiga asalnya. Artinya jika segitiga asalnya sama kaki, maka segitiga baru yang terbentuk juga merupakan segitiga sama kaki. Kemudian jika segitiga asalnya sama sisi, maka segitiga baru yang terbentuk juga merupakan segitiga sama sisi. Selanjutnya jika segitiga asalnya sembarang, maka segitiga baru yang terbentuk juga merupakan segitiga sembarang.
KAJIAN KEKUATAN Z-MODUL Q SEBAGAI INSPIRASI MUNCULNYA KONSEP DAN SIFAT DALAM TEORI MODUL
Authors: Wahyuni Sri , Anwar Yunita Septriana , Prabhadika I Putu Yudi 
Published: May 2022

Abstrak. Grup bilangan rasional (Q, +) sebagai modul atas daerah integral bilangan bulat (Z, +,˙) (Z-modul Q) merupakan contoh modul khusus yang mempunyai sifat-sifat yang unik yang sangat penting dalam munculnya konsep dan sifat dalam aljabar, khususnya dalam teori modul. Sifat yang sudah sangat dikenal adalah Z-modul Q merupakan modul torsi yang tidak bebas, dan lebih jauh modul Z-modul Q/Z merupakan modul torsi tak hingga. Dalam paper ini akan dipersentasikan hasil kajian Z-modul Q dalam kaitannya dengan struktur modul faktorisasi tunggal. Diperoleh bahwa Z-modul Q mempunyai sifat tidak memiliki elemen primitif yang kemudian berakibat dalam Z-modul Q tidak terdapat submodul siklik yang dibangun oleh suatu elemen primitif yang merupakan submodul murni. Selanjutnya akan dikaji peran Z-modul Q dalam kaitannya dengan konsep D-submodul fraksional dan konsep M -ideal fraksional dalam teori modul aritmatik. Lebih jauh akan dikaji sifat Z-modul Q dalam kaitannya dengan modul injektif dan modul miskin. Diperoleh sifat Z-modul Q mempunyai sifat keterbagian, keinjektifan, dan merupakan amplop injektif bagi setiap submodul Q. Sebagai ring, Q merupakan ring semisederhana dan Artinian sehingga setiap modul atas Q merupakan modul miskin.
Maintenance of potato varieties in <i>in vitro</i> and field collections of the Russian Potato Research Centre
Authors: Oves E. V. , Gaitova N. A. , Shishkina O. A. 
Published: May 2022

The main biological feature of potato varieties is vegetative reproduction. This mode of reproduction can be associated with problems due to the physiological ageing of the crop and the accumulation of specific pathogens causing reduced tuber yields. In order to avoid these problems, potato seed production widely uses modern biotechnological methods. The use of meristemic technologies allows preserving the identity of the biomaterial in the process of maintaining the potato collection in vitro, but even under these conditions there is a threat that modifications of individual economically valuable traits may get fixed. In potato varieties, such non-heritable deviations manifest themselves in the form of a shift in phenophases and the period of tubers ripening. The use of modern high-tech methods of varietal resources storage implemented on the basis of biotechnological approaches, makes it possible to maintain high quality of biomaterial. At the same time, mobility and practicality remain the main criteria for the effectiveness of different storage methods, depending on the extent to which they can be used in practice. In this review, the collection of varieties at Russian Potato Research Center is used as an example for considering the main stages of the formation and functioning of a modern Bank of Healthy Potato Varieties (BHPV), which supplies various regions of the Russian Federation with high-quality phytopathogen-free potato varieties.