bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulatory changes of local produced prostaglandins in corpus luteum after experimentally induced luteolysis in the cow
Authors: Berisha Bajram , Thaqi Granit , Rodler Daniela , Schams Dieter , Sinowatz Fred , Pfaffl Michael W. 
Published: February 2022

AbstractThe objective of the study was to evaluate the expression patterns of prostaglandin F2alpha (PGF), prostaglandin E2 (PGE), PGF receptor (FP), PGE receptors (EP2 and EP4), prostaglandin‐endoperoxide synthase 2 (PTGS2) and prostaglandin synthases (PGFS and PGES) in corpora lutea (CL) during experimentally induced luteolysis in cow. The Fleckvieh cows in the mid‐luteal phase (days 8–12, control group) were injected with cloprostenol (PGF analogue), and CL were collected by transvaginal ovariectomy before (days 8–12, control group) and at 0.5, 2, 4, 12, 24, 48 and 64 h after PGF application (n = 5 per group). The mRNA expression was determined by RT‐qPCR, the hormone concentrations by enzyme immunoassay and localization by immunohistochemistry. PTGS2 gene expression increased significantly 2 h after PGF application, followed by continuous and significant downregulation afterwards. The PGF tissue concentration increased significantly just after PGF injection and again during structural luteolysis (after 12 h), whereas PGE concentration significantly decreased during structural luteolysis. The FP receptor mRNA decreased significantly at 2 h and again at 12 h after PGF. In contrast, EP4 receptor mRNA increased significantly just after the PGF application (0.5 h). The immunostaining of PGES and PTGS2 on day 15–17 shows numerous positive luteal cells, followed by lower activity afterwards on day 18 (luteolysis). In conclusion, the changes of examined prostaglandin family members in CL tissue after PGF application may be key components of the local mechanisms regulating the cascade of actions leading to functional and subsequent structural luteolysis in the bovine ovary.
Managing advanced prostate cancer in the Asia Pacific region: “Real‐world” application of Advanced Prostate Cancer Consensus Conference 2019 statements
Authors: Chiong Edmund , Murphy Declan G. , Buchan Nicholas C. , Chua Melvin L. K. , Hakim Lukman , Hamid Agus Rizal , Hong Sung K. , Horvath Lisa G. , Kanesvaran Ravi , Khochikar Makarand , Letran Jason , Lojanapiwat Bannakij , Malek Rohan , Ng Anthony C. F. , Vinh Nguyễn Tuấn , Pang See‐Tong , Poon Darren M. C. , Ong Teng Aik , Saad Marniza , Schubach Kathryn , Shiroki Ryoichi , Türkeri Levent , Williams Scott , Wong Alvin , Ye Dingwei ,   ANZUP Cancer Trials Group, Davis Ian D. 
Published: February 2022

AbstractAimThe second Asia‐Pacific Advanced Prostate Cancer Consensus Conference (APAC APCCC 2020) gathered insights into the real‐world application in the Asia‐Pacific (APAC) region of consensus statements from the 3rd Advanced Prostate Cancer Consensus Conference (APCCC 2019).MethodsThe 4‐h our virtual meeting in October 2020 brought together 26 experts from 14 APAC countries to discuss APCCC 2019 recommendations. Presentations were prerecorded and viewed prior to the meeting. A postmeeting survey gathered views on current practice.ResultsThe meeting and survey highlighted several developments since APAC APCCC 2018. Increased access and use in the region of PSMA PET/CT imaging is providing additional diagnostic and staging information for advanced prostate cancer and influencing local and systemic therapy choices. Awareness of oligometastatic disease, although not clearly defined, is increasing. Novel androgen receptor pathway antagonists are expanding treatment options. Cost and access to contemporary treatments and technologies continue to be a significant factor influencing therapeutic decisions in the region. With treatment options increasing, multidisciplinary treatment planning, shared decision making, and informed choice remain critical. A discussion on the COVID‐19 pandemic highlighted challenges for diagnosis, treatment, and clinical trials and new service delivery models that will continue beyond the pandemic.ConclusionAPAC‐specific prostate cancer research and data are important to ensure that treatment guidelines and recommendations reflect local populations and resources. Facilitated approaches to collaboration across the region such as that achieved through APAC APCCC meetings continue to be a valuable mechanism to ensure the relevance of consensus guidelines within the region.
Hemodynamic assessment and risk classification for successful weaning of Impella in patients with cardiogenic shock
Authors: Ikeda Yuki , Ishii Shunsuke , Maemura Kenji , Oki Takumi , Yazaki Mayu , Fujita Teppei , Iida Yuichiro , Kinoshita Daisuke , Sato Nobuhiro , Ako Junya 
Published: February 2022

AbstractBackgroundClinical predictors for successful weaning of patients from Impella heart pump have not been clarified. We aimed to elucidate the relationship between pulmonary artery catheter (PAC) parameters at the time of Impella weaning and subsequent outcomes.MethodsWe enrolled consecutive patients who had received Impella for cardiogenic shock. PAC data were collected immediately before Impella weaning. Patients were classified as non‐survivors if they died or required any mechanical circulatory support reintroduction within 30 days of weaning.ResultsOf 81 patients enrolled, 61 underwent Impella weaning. Of these, 16 were non‐survivors. Predictive indicators of non‐survival were high pulmonary artery wedge pressure (PAWP; hazard ratio [HR] per 5 mm Hg 1.97, 95% CI 1.35–2.80; p < 0.001), high mean pulmonary artery pressure (MPAP; HR per 5 mm Hg 1.90, 1.38–2.58; p < 0.001), and low cardiac power output (CPO; HR per 0.1 Watts 0.71, 0.52–0.92; p = 0.006). Cutoff values of PAWP 20 mm Hg, MPAP 22 mm Hg, and CPO 0.59 Watts showed strong associations with 30‐day non‐survival risk (low risk 8% in patients with low PAWP and high CPO or 4% in patients with low MPAP and high CPO; high risk 100% in patients with high PAWP and low CPO or 82% in patients with high MPAP and low CPO).ConclusionsPAWP or MPAP higher than the cutoff with CPO below the cutoff at Impella weaning were associated with worse outcomes. We proposed a risk classification model for successful Impella weaning using PAC.
Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation
Authors: Du Junyan , Kageyama Shun‐Ichiro , Yamashita Riu , Hirata Hidenari , Hakozaki Yumi , Okumura Masayuki , Motegi Atsushi , Hojo Hidehiro , Nakamura Masaki , Hirano Yasuhiro , Sunakawa Hironori , Minamide Tatsunori , Kotani Daisuke , Tanaka Kosuke , Yano Tomonori , Kojima Takashi , Ohashi Akihiro , Tsuchihara Katsuya , Akimoto Tetsuo 
Published: February 2022

AbstractRadiotherapy (RT) combined with immune checkpoint inhibitors has recently produced outstanding results and is expected to be adaptable for various cancers. However, the precise molecular mechanism by which immune reactions are induced by fractionated RT is still controversial. We aimed to investigate the mechanism of the immune response regarding multifractionated, long‐term radiation, which is most often combined with immunotherapy. Two human esophageal cancer cell lines, KYSE‐450 and OE‐21, were irradiated by fractionated irradiation (FIR) daily at a dose of 3 Gy in 5 d/wk for 2 weeks. Western blot analysis and RNA sequencing identified type I interferon (IFN) and the stimulator of IFN genes (STING) pathway as candidates that regulate immune response by FIR. We inhibited STING, IFNAR1, STAT1, and IFN regulatory factor 1 (IRF1) and investigated the effects on the immune response in cancer cells and the invasion of surrounding immune cells. We herein revealed type I IFN‐dependent immune reactions and the positive feedback of STING, IRF1, and phosphorylated STAT1 induced by FIR. Knocking out STING, IFNAR1, STAT1, and IRF1 resulted in a poorer immunological response than that in WT cells. The STING‐KO KYSE‐450 cell line showed significantly less invasion of PBMCs than the WT cell line under FIR. In the analysis of STING‐KO cells and migrated PBMCs, we confirmed the occurrence of STING‐dependent immune activation under FIR. In conclusion, we identified that the STING‐IFNAR1‐STAT1‐IRF1 axis regulates immune reactions in cancer cells triggered by FIR and that the STING pathway also contributes to immune cell invasion of cancer cells.
Clinical question: How to manage symptoms of hypogonadism in patients after androgen abuse?
Authors: Botman Esmée , Smit Diederik L. , de Ronde Willem 
Published: February 2022

AbstractAndrogen abuse is relatively common amongst young (amateur) bodybuilders. After cessation, the hypothalamic‐pituitary‐gonadal (HPG) axis—which has been suppressed by the androgens—needs time to recover. The endogenous testosterone production often recovers within 3 months, however, prolonged or permanent post‐androgen abuse hypogonadism (PPAAH) has been described. There is no widely accepted definition nor is its pathogenesis completely elucidated. To date it is a subject of debate whether PPAAH is a separate entity, reflecting irreversible damage to essential components of the HPG axis inflicted by long‐term exposure to high doses of androgens. Alternately, it may be the result of longer than expected suppressive effects of androgen depots, undisclosed ongoing androgen abuse or undiagnosed unrelated disorders. Due to the lack of scientific evidence, the management of PPAAH is challenging. By combining clinical experience with evidence from the recent literature, a suggested outline of the management of androgen‐abuse‐induced hypogonadism are given.
‘Because I'm a kid …’: The struggle for recognition of children and young people involved in child and family social work
Authors: Mitchell Mary 
Published: February 2022

AbstractChildren's participation in decision‐making remains a key focus of social work practice. Yet the protection and participation of children in our society remains a setting of tension for children, families and practitioners. Drawing on evidence from a retrospective qualitative study on Family Group Conferencing, this paper uses the lens of recognition theory to highlight the experiences of young people more broadly in the social work system. The study found social workers' attitudes affected children and young people's capacity to be ‘partners’ in decision‐making. Feelings of misrecognition can create barriers for how children and young people perceive and interact with social work professionals. While small, this study sheds light on the experiences of young people's struggles for recognition when involved in the social work system. Further research is needed on this topic to fully understand the implications of (mis)recognition in social work practice.
A multiscale cell‐based model of tumor growth for chemotherapy assessment and tumor‐targeted therapy through a 3D computational approach
Authors: Jafari Nivlouei Sahar , Soltani Madjid , Shirani Ebrahim , Salimpour Mohammad Reza , Travasso Rui , Carvalho João 
Published: February 2022

AbstractObjectivesComputational modeling of biological systems is a powerful tool to clarify diverse processes contributing to cancer. The aim is to clarify the complex biochemical and mechanical interactions between cells, the relevance of intracellular signaling pathways in tumor progression and related events to the cancer treatments, which are largely ignored in previous studies.Materials and MethodsA three‐dimensional multiscale cell‐based model is developed, covering multiple time and spatial scales, including intracellular, cellular, and extracellular processes. The model generates a realistic representation of the processes involved from an implementation of the signaling transduction network.ResultsConsidering a benign tumor development, results are in good agreement with the experimental ones, which identify three different phases in tumor growth. Simulating tumor vascular growth, results predict a highly vascularized tumor morphology in a lobulated form, a consequence of cells' motile behavior. A novel systematic study of chemotherapy intervention, in combination with targeted therapy, is presented to address the capability of the model to evaluate typical clinical protocols. The model also performs a dose comparison study in order to optimize treatment efficacy and surveys the effect of chemotherapy initiation delays and different regimens.ConclusionsResults not only provide detailed insights into tumor progression, but also support suggestions for clinical implementation. This is a major step toward the goal of predicting the effects of not only traditional chemotherapy but also tumor‐targeted therapies.
Villain or scapegoat? Elephants and academic achievement of pupils and schools in Trans Mara District, Kenya
Authors: Nyumba Tobias Ochieng , Leader‐Williams Nigel 
Published: February 2022

AbstractImproving human capital through quality education remains a global and national priority, particularly for developing countries. Academic performance is the standard indicator of a successful acquisition of the knowledge, skills, and attitudes for improving human capital. However, recent data, particularly in wildlife areas shows that pupils often perform poorly on academic tests in low‐income countries. This study aims to determine the impact of elephants on academic performance in Trans Mara District, Kenya. We use data from 137 schools and 749 pupils who wrote the Kenya Certificate of Primary Education between 2010 and 2014, and 15 key informants. We used descriptive statistics to analyze and interpret our data. Results show that locating a school outside the elephant range positively contributed to higher mean scores compared to ethnicity, pupil–teacher ratio and gender. Whereas day facilities only strongly contributed to lower scores compared to examination entry, age of the pupil, and ethnicity. The study places elephants on both ends of the villain‐scapegoat continuum since their presence alone does not make a major contribution to poor academic performance in the Trans Mara District. We recommend providing cheaper and accessible transport to pupils, expanding both day and boarding facilities, establishing additional schools closer to pupils within elephant range to reduce the distances to school. These initiatives must be linked to the conservation of elephants as a suit of direct incentives for coexisting with elephants.
Delivery of an online psychosocial recovery program during COVID‐19: A survey of young people attending a youth mental health service
Authors: Somaiya Janaki , Thompson Andrew , O'Donoghue Brian , Brown Ellie 
Published: February 2022

AbstractAimsThe COVID‐19 pandemic forced the rapid move of mental health services to being delivered online. This included the delivery of a psychosocial recovery program (PRP) delivered in youth mental health services in Melbourne, Australia which consists of groups that address functional recovery. At the time, there was limited evidence about how this switch in service provision would be received by service users or what impact the pandemic was having on their mental health.MethodsYoung people engaged with the PRP between March and May 2020 were sent a link to complete an online survey that was co‐developed by young people and clinicians. Attendance data at groups were extracted as a proximal measure of feasibility and acceptability.ResultsA total of 44 young people undertook the survey with the domains of wellbeing most impacted by lockdown being work/study, motivation and social connection. Groups provided online were generally well attended during lockdown, particularly those that had a focus on therapeutic content. Young people indicated little preference for continuing to attend groups run purely online when restrictions eased, with many expressing a preference for these to be offered face‐to‐face or in a combined format.ConclusionsThese findings suggest that implementation of online psychosocial groups during periods of lockdown is both feasible and acceptable. Whilst young people found accessing groups online to be of benefit at the time, they felt that continued substitution of face‐to‐face groups would not necessarily be preferable and clinical services should consider these preferences in their long‐term service delivery.
Catholicity and Conciliarity as Challenges for Christian Churches Today
Authors: Chalamet Christophe 
Published: February 2022

AbstractTeaching ecumenism in the context of global Christianity raises the question of how to approach the themes of “catholicity” and “conciliarity.” This article addresses some of the challenges and possible paths in relation to this topic. At a time when universalism is often (and rightly) denounced, can or should there be room for a sense of the church’s universality or catholicity? Or is universality always an instrument in the service of hegemonic (mostly Western) quests for domination? The paper seeks to show how universality entails a mutual, ongoing dialogue in which all parties involved may set the agenda and contribute. This connects to conciliarity or synodality, a much‐discussed theme in Roman Catholicism, in the Orthodox world, and among Protestant churches worldwide. The article presents some of the challenges the churches have been and are facing as they seek to become more authentically synodal churches.
Is Ecumenism Even Possible in the Context of World Christianity?
Authors: De La Torre Miguel A. 
Published: February 2022

AbstractEcumenism is difficult to achieve because Eurochristianity dominates the discourse, thus masking its complicity with oppression. Those from the global South who adopt the white Jesus of the colonizers become complicit with their own oppression. For ecumenism to occur, the decolonization of the minds of those on the margins must first take place by rejecting Eurochristianity and interpreting their faith through their own indigenous symbols. This process may require ecumenical conversations within the global South apart from the global North. And for whites to eventually join the ecumenical discourse, they must first crucify their whiteness and bow their knees to the Jesus of the oppressed.
Being Roman Catholic Today in a Worldwide Context
Authors: Sattler Dorothea 
Published: February 2022

AbstractTaking the example of the Roman Catholic Church, this article focuses on the role in the formation of ecumenical consciousness of acquiring knowledge about the current reform processes in confessional communities other than one’s own. It begins with an account of current reform efforts in the Roman Catholic Church, keeping in mind the ecumenical context. It then goes on to recall how, according to the Second Vatican Council, the catholicity of the one church of Jesus Christ is not identical with the institutional shape of the Roman Catholic Church. The article concludes with a set of theses that consider the significance for ecumenical formation and education of how we perceive developments in confessions other than our own.
New Ecumenism in a Discriminatively Divided World
Authors: Kim Un‐Hey 
Published: February 2022

AbstractThis article explores the idea of a new ecumenism as the basis for teaching ecumenism more relevantly and emphatically in the reality of the COVID‐19 pandemic. This new ecumenism is about the symbiosis of the divine family, not simply the unity of the Christian family or the solidarity of the human family. This requires a paradigm shift toward seeking a path with all beings and creatures on Earth in accordance with the will of God – who still works faithfully for the ultimate salvation. Not only are humans created by God, but our fellow creatures are all also partners for salvation. Ecumenism needs to be about sympoiesis, making‐life‐with‐other beings, especially in the Anthropocene epoch, when people are divided not just by race, nation, gender, and class, but also by anthropocentric ways of life. What is needed is not just an eco‐friendly ecumenism but a sympoietic ecumenism, through which we treat every being on this planet as part of our extended family.
Teaching Ecumenism in the Context of World Christianity
Authors: Sinn Simone 
Published: February 2022

AbstractThe conference “Teaching Ecumenism in the Context of World Christianity,” held in June 2021, was an initiative of the Ecumenical Institute at Bossey together with related programme units in the World Council of Churches. This article offers background to this initiative by sketching historical developments in the field of teaching ecumenism and by outlining creative synergies and tensions that have emerged in relation to academic scholarship in the area of World Christianity. By bringing together colleagues teaching in the areas of ecumenical studies, World Christianity, and related fields, the conference aimed to enter more deeply into conversations around epistemologies and methodologies, where participatory approaches engage discourses like global‐versus‐local and unity‐versus‐diversity in a critical and constructive way.
Evaluation of physicochemical properties and microbial counts of raw and cooked low‐fat patties added with eggplant powder prepared with different drying methods
Authors: br Sembring Hanna Seprina , Chin Koo Bok 
Published: February 2022

SummaryEffects of different drying methods and different addition levels of eggplant (EP) on product quality of low‐fat patties (LFPs) were investigated during storage. EP was dried in an oven dryer at 60 °C or a freeze dryer at −50 °C. LFPs were prepared by replacing with 1.5% soy protein isolate (SPI). Six treatments were used in this study: (1) control (CTL), without addition of EP; (2) reference (REF), 0.1% ascorbic acid; (3) O1, 0.25% oven‐dried (OD) EP; (4) O2, 0.5% ODEP; (5) F1, 0.25% freeze‐dried (FD) EP; and (6) F2, 0.5% FDEP. Redness (a*) and lightness (L*) values in LFPs added with EP were lower than those of others (p < 0.05) and decreased with increasing storage time. Yellowness (b*) values of cooked patties were increased during storage time (p < 0.05), with control having the highest value. The addition of EP or ascorbic acid into LFPs lowered microbial counts than control (p < 0.05). Thiobarbituric acid reactive substances (TBARS) was increased during storage, with REF having the lowest value, and patties added with EP had lower TBARS values than control during storage. Volatile basic nitrogen (VBN, mg%) contents of all patties also increased during storage time with O2 and F2 having lower values than control. Therefore, EP might have potential as a natural antioxidant in meat products during storage.
Investigation of the antioxidation capacity of gallic acid and its alkyl esters with different chain lengths for dried oyster during ambient storage
Authors: Zhao Man‐Tong , Liu Zhong‐Yuan , Zhao Guan‐Hua , Li De‐Yang , Xia Guang‐Hua , Yin Fa‐Wen , Zhou Da‐Yong 
Published: February 2022

SummaryThe antioxidant capacity of gallic acid (GA) and its fatty alkyl esters such as butyl gallate, octyl gallate (OG), lauryl gallate and hexadecyl gallate in freeze‐dried oyster was investigated. During ambient storage, the significant increase of peroxide value and thiobarbituric acid value together with the decline for docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) contents indicated the occurrence of lipid autoxidation in freeze‐dried oysters. Meanwhile, the oxidative degradation of glycerol phosphocholine (GPC), glycerol phosphoethanolamine (GPE) and triacylglycerols (TAG) molecular species carrying DHA or EPA in oyster ranked as: TAG > GPE > GPC. GA and its alkyl esters could effectively be prevented dried oyster lipid from oxidation. Among them, OG stood out as the most effective individual. This work implied that the chain lengths of GA alkyl esters affect their antioxidant ability for dried oysters, which provides the information for selecting eligible antioxidants to enhance the oxidative stability of freeze‐dried seafood.