bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visual Identity Emping Jagung Yahya Barokah Sebagai Identitas Usaha
Authors: Pratiwi Arin Enggar , Irsyada Abdulloh Eizzi 
Published: July 2022

Corn Emping Yahya Barokah is a business founded by the Pardi family. He owns a shop at Jalan Simpang Teluk Bayur No.12 RT.04 / RW.08. Pardi admits that he has been working with SMEs for corn-processed snacks since 16 years ago. In the production process, corn is soaked in lime, then washed, dried in the sun, and boiled half cooked. After that, the corn grains are removed and ground to make flat marning. As for the blooming merning, the corn is not ground. The corn marning production process takes up to five days from corn to snack food.The research method used is observation, namely direct observation to the destination location and conducting interviews with the business owner of Emping Corn Yahya Barokah then supported by literature studies sourced from books and journals. The process of designing logos, GSM books, packaging, X-Banners and Merchandise starts from Pre-production covering production, post-production, distribution and testing of product effectiveness through the media of a target audience questionnaire.After the validation test was carried out through questionnaires that were distributed randomly, it showed that the re-branding I made about Yahya Barokah's Corn Chips Industry was included in the appropriate category with an assessment from 30 respondents. Thus, the re-branding has succeeded in subtly influencing the audience and at the same time becoming a promotional medium for Yahya Barokah's Corn Chips Industry.
Keywords: Visual Identity, Media, Promotion, Corn Chips.
Buku Bergambar “Self Healing” Sebagai Media Edukasi Untuk Remaja Pasuruan
Authors: Saputra Teguh Adi , Hendrawan Faldi 
Published: July 2022

Pasuruan is an area that has many talented young people. As an area with a lot of potential for the younger generation, Pasuruan is very concerned about education on their mental health. However, the development of awareness of self-healing is quite slow due to the influence of some social environments that pay less attention to mental health and mental wounds. Another factor is the lack of educational media regarding self-healing. Therefore, it is necessary to make some kind of illustration for educational media in the form of picture books, so that teenagers know that mental wounds can be healed by self-healing. The research method used in conducting this research is observation, namely making direct observations to the intended location and conducting interviews with resource persons. Then supported by literature study sourced from books and journals. The design process for making this picture book starts from the Pre-Production stage which includes the script and rough layout. For the Production process is the character visualization process, coloring, editing process. And for the Post-Production process is the process of finishing, publishing and testing. The test was carried out through a media questionnaire which was distributed to 30 respondents of late teens to find out how well they understood this book. The results of the questionnaire show that this book can be understood well. Thus, this self-healing picture book is appropriate to be used as an educational medium for teenagers.
Keywords : Ilustrated book, media education, caracter cisualisation, self healing.
La mirada en El amante del teatro y el artilugio de la intertextualidad
Authors:   Universidad de Quintana Roo, Reyes Velázquez Amparo 
Published: July 2022

El objetivo de este trabajo es abordar la temática de la mirada en el relato El amante del teatro, pero además, en este cuento, que atisba recovecos de otros planos de la ficción narrativa, resulta necesario esbozar un guiño del universo intertextual que subyace. Así pues, El amante del teatro, por tratarse de un relato fantástico, los estudios de Tzvetan Todorov resultan imprescindibles para el marco teórico.	El amante del teatro es la historia fantasmagórica que borra los límites entre la realidad y la fantasía, donde la literatura nos crea una realidad distinta a la nuestra, extraordinariamente mejor, basta, inimaginable… como ha señalado Mario Vargas Llosa.
Docencia, didáctica y principios bioéticos para la enseñanza de la filosofía
Authors:   Universidad Autónoma de Chiapas, Ruiz-Rincón Diana Lizbeth 
Published: July 2022

El presente artículo tiene como objetivo abonar a las reflexiones en torno a la docencia, la didáctica y la enseñanza de la filosofía, desde una mirada bioética. De esta manera, la idea central de este texto se articula a través de cuatro apartados; en primer lugar, se integran una serie de notas en torno a la noción de docencia, acepción situada como actividad-activa en un modelo de educación centrada en el docente. En un segundo momento de nuestra exposición, ubicaremos a la didáctica como una actividad-pasiva en el seno de la vida áulica centrada en el estudiante como mero receptor; permitiéndonos con ello pensar a la enseñanza de la filosofía además de como práctica dialéctica de carácter dialógico, como enmarcada en principios bioéticos.	Lo anterior obedece a una preocupación genuina por repensar a la enseñanza de la filosofía más allá de una mera actividad formadora, sino como una serie de compromisos que nos instalan en una actividad propiamente humana y a la que hay siempre que retomar, con nuevas y provocadoras interrogantes y posiciones. En este sentido, el marco bioético, nos permitirá entretejer pluridisciplinarmente, al ser humano en una violencia contra sí mismo para incluir en la reflexión ética de su modo de relacionarse con el medio ambiente.
Violencia contra la mujer en el barrio Ciudad Alegría de la ciudad de Loja
Authors: Ayala Erráez Alexandra Luzmila , Rivera Costales José Alberto , Tapia Segarra Jenny Irlanda 
Published: July 2022

La violencia contra la mujer se transformó en un problema social y de salud, por lo tanto, diferentes acciones se realizan para tratar de detener este fenómeno, sin embargo, no ha sido posible en su lugar Ecuador reporta cifras alarmantes de violencia, por tal razón, se realiza esta investigación cuyo objetivo es prevenir la violencia contra las mujeres en el barrio Ciudad Alegría de la ciudad de Loja, mediante la propuesta de un Programa de Trabajo Social que concientice a las familias de este sector sobre la importancia del reconocimiento de sus derechos con la finalidad de generar una convivencia libre de violencia. El estudio de corte cuantitativo se basa en la aplicación de encuestas a 344 mujeres del barrio Ciudad Alegría de la ciudad de Loja, las mismas que analizadas estadísticamente demuestran que prevalece la violencia psicológica en un 55.52%, aunque no se registra que exista violencia sexual en la muestra obtenida, pero este resultado no concuerda con el tipo de valoración que dan a su ambiente familiar, por lo cual, el trato que recibe la mujer dentro de su hogar es considerado como una rutina o parte de su diario vivir. Según los resultados las mujeres son conscientes de ser víctimas de violencia (99,42%), pero lo soportan y permiten que el abuso de poder por parte del hombre y desigualdad entre hombres y mujeres siga creciendo y se difunda, acciones fomentadas desde el núcleo familiar, por reacciones negativas de familiares y vergüenza a la sociedad. Adicionalmente, las principales características de violencia contra la mujer son la reiteración de epítetos que menoscaban la dignidad, menosprecio y desvalorización al generar consecuencias notables como el estrés, la ansiedad y la desconfianza hacia las demás personas.
Scrabble Game: Boosting Vocabulary Mastery of English Foreign Language (EFL) Students
Authors: Tuti Tuti , Ilinawati Ilinawati 
Published: July 2022

The background of this research is the lack of student participation and involvement in learning English in the classroom especially for vocabulary learning. This is caused by the lack of students’ motivation, laziness and less understanding of students in mastering vocabulary. The purpose of this research is to describe the students’ participation and the students’ improvement in vocabulary after applying scrabble games. The method used in this research was Classroom Action Research (CAR). The data collection technique of this research are observation, interview, and measurement. The tools of data collection technique are observation sheet, interview guideline, and test. The researchers applied Classroom Action Research (CAR) where the data divided into two kinds of descriptions; they were Qualitative and quantitative. The researchers obtained the data from cycle one and cycle two and then described it into qualitative and quantitative description. From data the analysis, it showed that there was a significant improvement in the students' participation and students vocabulary mastery. It can be seen from qualitative and quantitative data. From qualitative data, the students’ participations were increased from the first cycle into two cycle. Meanwhile, from quantitative data, the result of the test improved significantly from both cycles. It could be concluded that the scrabble game technique improved students’ vocabulary mastery.
FACTORS RELATED TO WORK ACCIDENTS ON WASTE MANAGEMENT WORKERS (CASE STUDY IN FINAL PROCESSING PLACE : PECUK INDRAMAYU DISTRICT AND GUNUNG SANTRI CIREBON DISTRICT) IN 2020
Authors: Nurhayati Mei 
Published: July 2022

The role of waste management personnel who work every day to overcome the dangers of environmental pollution due to waste, these workers are at risk of work accidents. The aim is to find out the factors related to work accidents in waste management personnel. Using cross sectional and focus group discussion. The total sampling is 33 respondents. Workers who have an accident will be treated with First Aid in Accidents, even the Environmental Service will follow up. Variables related to work accidents are working hours (ρ=0.023), age (ρ=0.005), fatigue (ρ=0.027). Working hours variable with regression coefficient value = 0.061, age variable with regression coefficient value = 0.020. First Aid in Accidents at work still does not meet the requirements, and workers also do not use complete Personal Protective Equipment. Variable hours of work, age, fatigue associated with work accidents. There is no dominant factor associated with work accidents. It is necessary to hold an Occupational Health and Safety program. Keyword: Work Accident Factors, Waste Management Personnel, Final Processing Place.
Comparisons of Metastatic Patterns, Survival Outcomes and Tumor Immune Microenvironment Between Young and Non-Young Breast Cancer Patients
Authors: Sun Hengwen , Huang Wei , Ji Fei , Pan Yi , Yang Lu 
Published: July 2022

Background: Metastases are the main cause of breast cancer-related deaths. Breast cancer has a more aggressive phenotype and less favorable prognosis in young females than in older females. In this study, we aimed to compare the metastatic patterns, survival outcomes and tumor immune microenvironment of young and non-young breast cancer patients.Methods: Patients with a diagnosis of breast cancer were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015. The significance of young age (≤40 years) in the metastatic profile and prognosis of breast cancer was investigated. The transciptome expression data were acquired from The Cancer Genome Atlas (TCGA) database. And the differentially expressed genes (DEGs) and primarily enriched function pathways were identified by comparing between young and non-young breast cancer samples, and tumor immune infiltrating cell types in the tumor microenvironment were compared.Results: A total of 281,829 female breast cancer patients were included in SEER: 18,331 young (6.5%) and 263,498 non-young (93.5%) women. The metastatic rates of bone, liver and distant lymph nodes (DLNs) in the young cohort were significantly higher than those in the non-young cohort. The most frequent two-site metastatic combination was bone and liver (0.61%) in the young cohort, whereas it was bone and lung (0.32%) in the non-young cohort. Breast cancer-specific survival (BCSS) was significantly shortened among those in the young cohort compared with those in the non-young cohort (p &lt; 0.001). Young age was associated with significantly shorter BCSS only among patients with HR+/HER2- tumors (p &lt; 0.001). The enriched biological pathways based on DEGs between two cohorts were related to the regulation of immune response and several metabolic processes. M2 macrophages were significantly abundant in non-young breast cancer than young breast cancer.Conclusion: Young and non-young breast cancer patients present with different metastatic patterns. Young age is a negative prognostic factor, particularly for HR+/HER2- breast cancer. The differences in metastatic patterns between young and non-young cohorts should be taken into account in the clinical management of metastatic breast cancer. The young breast cancer patients may gain better response to immunotherapy due to immune activated TME than non-young breast cancer.
Conceptual DFT, QTAIM, and Molecular Docking Approaches to Characterize the T-Type Calcium Channel Blocker Anandamide
Authors: Rangel-Galván Maricruz , Castro María Eugenia , Perez-Aguilar Jose Manuel , Caballero Norma A. , Melendez Francisco J. 
Published: July 2022

The anandamide is a relevant ligand due to its capacity of interacting with several proteins, including the T-type calcium channels, which play an important role in neuropathic pain and depression disorders. Hence, a detailed characterization of the chemical properties and conformational stability of anandamide may provide valuable information to understand its behavior in a biological context. Herein, conceptual DFT and QTAIM analyses were performed to theoretically characterize the chemical reactivity properties and the structural stability of conformations of anandamide, using the BP86/cc-pVTZ level of theory. Global reactivity description, based on conceptual DFT, indicates that the hardness increases and the electrophilicity index decreases for both, the hairpin and U-shape conformers relative to the extended conformers. Also, an increase in the chemical potential value and a decrease in the electronegativity and the electrophilicity index is observed in the ethanolamide open ring conformers in comparison with the corresponding closed ring structures. In addition, regarding the characterization of local reactivity descriptors, the maximum values of the Fukui and Parr functions indicate that the most probable location for a nucleophilic attack is either the hydroxyl oxygen located in the ethanolamide closed ring conformers or the carbonyl oxygen present in the open ring conformers. The most probable location for an electrophilic attack is in the alkyl double bond region in all anandamide conformers. According to the QTAIM results, the intramolecular hydrogen bond formation stabilizing the structure of anandamide has interaction energy values for the closed ring conformations of 12.33–12.46 kcal mol−1, indicating a strong interaction. Lastly, molecular docking calculations determined that a region in the pore, denominate as pore-blocking, is a probable site for the interaction of anandamide with the human Cav3.2 isoform of the T-type calcium channel family. The pore-blocking site contains hydrophobic residues where the non-polar part in the final alkyl region of anandamide established mainly alkyl-alkyl interactions, while the polar part (the ethanolamide group) interacts with the polar residue S900. The information based on conceptual DFT presented may aid in the design of drugs with similar chemical characteristics as those identified in anandamide so as to bind anandamide-interacting proteins, including the T-type calcium channels.
Performance of a Mid-Infrared Sensor for Simultaneous Trace Detection of Atmospheric CO and N2O Based on PSO-KELM
Authors: Li Guolin , Zhang Zecheng , Zhang Xuena , Wu Yunhui , Ma Kun , Jiao Yue , Zhao Hao , Song Yimeng , Liu Yajing , Zhai Shenqiang 
Published: July 2022

In this article, a field deployable sensor was developed using a self-developed 4.58-µm continuous wave quantum cascade laser (CW-QCL) for the simultaneous detection of carbon monoxide (CO) and nitrous oxide (N2O), both of which have strong fundamental absorption bands in this waveband. The sensor is based on tunable diode laser absorption spectroscopy (TDLAS) technology, which combined a multi-pass gas cell (MPGC) with a 41 m optical path length to achieve high-precision detection. Meanwhile, the particle swarm optimization-kernel extreme learning machine (PSO-KELM) algorithm was applied for CO and N2O concentration prediction. In addition, the self-designed board-level QCL driver circuit and harmonic signal demodulation circuit reduce the sensor cost and size. A series of validation experiments were conducted to verify the sensor performance, and experiments showed that the concentration prediction results of the PSO-KELM algorithm are better than those of the commonly used back propagation (BP) neural networks and partial least regression (PLS), with the smallest root mean square error (RMSE) and linear correlation coefficient closest to 1, which improves the detection precision of the sensor. The limit of detection (LoD) was assessed to be 0.25 parts per billion (ppb) for CO and 0.27 ppb for N2O at the averaging time of 24 and 38 s. Field deployment of the sensor was reported for simultaneous detection of CO and N2O in the air.
Different Impacts on the Heart After COVID-19 Infection and Vaccination: Insights From Cardiovascular Magnetic Resonance
Authors: Gröschel Jan , Bhoyroo Yashraj , Blaszczyk Edyta , Trauzeddel Ralf Felix , Viezzer Darian , Saad Hadil , Fenski Maximilian , Schulz-Menger Jeanette 
Published: July 2022

IntroductionMyocarditis-like findings after COVID-19 (coronavirus disease 2019) infection and vaccination were reported by applying cardiovascular magnetic resonance (CMR). These results are very heterogenous and dependent on several factors such as hospital admission or outpatient treatment, timing of CMR, and symptomatic load. This retrospective study aimed to identify differences in myocardial damage in patients with persistent symptoms both after COVID-19 infection and vaccine by applying CMR.Materials and MethodsThis study entails a retrospective analysis of consecutive patients referred for CMR between August 2020 and November 2021 with persistent symptoms after COVID-19 infection or vaccination. Patients were compared to healthy controls (HC). All patients underwent a CMR examination in a 1.5-T scanner with a scan protocol including: cine imaging for biventricular function and strain assessment using feature tracking, T2 mapping for the quantification of edema, and T1 mapping for diffuse fibrosis and late gadolinium enhancement (LGE) for the detection and quantification of focal fibrosis. Patients were divided into a subacute COVID-19 (sCov) group with symptoms lasting &lt; 12 weeks, post-COVID-19 (pCov) group with symptoms &gt; 12 weeks, and patients after COVID-19 vaccination (CovVac).ResultsA total of 162 patients were recruited of whom 141 were included for analysis. The median age in years (interquartile range (IQR)) of the entire cohort was 45 (37–56) which included 83 women and 58 men. Subgroups were as follows (total patients per subgroup, median age in years (IQR), main gender): 34 sCov, 43 (37–52), 19 women; 63 pCov, 52 (39–58), 43 women; 44 CovVac, 43 (32–56), 23 men; 44 HC (41 (28–52), 24 women). The biventricular function was preserved and revealed no differences between the groups. No active inflammation was detected by T2 mapping. Global T1 values were higher in pCov in comparison with HC (median (IQR) in ms: pCov 1002ms (981–1023) vs. HC 987ms (963–1009; p = 0.005) with other parings revealing no differences. In 49/141 (34.6%) of patients, focal fibrosis was detectable with the majority having a non-ischemic pattern (43/141; 30.4%; patients) with the subgroups after infection having more often a subepicardial pattern compared with CovVac (total (% of group): sCov: 7/34(21%); pCov 13/63(21%); CovVac 2/44(5%); p = 0.04).ConclusionPatients after COVID-19 infection showed more focal fibrosis in comparison with patients after COVID-19 vaccination without alterations in the biventricular function.
High Prevalence of Common Human Viruses in Thyroid Tissue
Authors: Weider Therese , Genoni Angelo , Broccolo Francesco , Paulsen Trond H. , Dahl-Jørgensen Knut , Toniolo Antonio , Hammerstad Sara Salehi 
Published: July 2022

IntroductionEvidence points to viral infections as possible triggers of autoimmune thyroid disease (AITD), but little is known about the prevalence of common viruses in the thyroid gland. Using a novel approach based on virus enrichment in multiple cell lines followed by detection of the viral genome and visualization of viral proteins, we investigated the presence of multiple human viruses in thyroid tissue from AITD patients and controls.MethodsThyroid tissue was collected by core needle biopsy or during thyroid surgery from 35 patients with AITD (20 Graves’ disease and 15 Hashimoto’s thyroiditis). Eighteen thyroid tissue specimens from patients undergoing neck surgery for reasons other than thyroid autoimmunity served as controls. Specimens were tested for the presence of ten different viruses. Enteroviruses and human herpesvirus 6 were enriched in cell culture before detection by PCR and immunofluorescence, while the remaining viruses were detected by PCR of biopsied tissue.ResultsForty of 53 cases (75%) carried an infectious virus. Notably, 43% of all cases had a single virus, whereas 32% were coinfected by two or more virus types. An enterovirus was found in 27/53 cases (51%), human herpesvirus 6 in 16/53 cases (30%) and parvovirus B19 in 12/53 cases (22%). Epstein-Barr virus and cytomegalovirus were found in a few cases only. Of five gastroenteric virus groups examined, only one was detected in a single specimen. Virus distribution was not statistically different between AITD cases and controls.ConclusionCommon human viruses are highly prevalent in the thyroid gland. This is the first study in which multiple viral agents have been explored in thyroid. It remains to be established whether the detected viruses represent causal agents, possible cofactors or simple bystanders.