bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutational profiles of ovarian cancer in Chinese patients reveal potential therapeutic targets and prognostic markers
Authors: Lyu Tianjiao , Jiang Yahui , Ma Jinyan , Zhu Chongying , Shen Lifei , Sheng Yuhong , Liu Hua , Feng Weiwei 
Published: May 2022

Abstract
Background: Ovarian cancer (OC) is a common and lethal gynaecologic malignancy. The prognosis of OC is variable among different patients treated with standard of care therapies. Herein, we described the mutational profiles of OC to identify underlying therapeutic targets and prognostic markers.Methods: The study was performed on 38 Chinese patients with high-grade serous ovarian cancer (HGSOC). Most patients (86.8%) had advanced disease (stage III-IV). Tissue samples were subjected to capture-based targeted sequencing using a panel consisting of 520 cancer-related genes. Mutational profiles, including gene mutations and copy number variations (CNVs), were evaluated in each patient. Homologous recombination deficiency (HRD) status was also assessed. Analysis of the mutational profile with platinum-sensitivity, progression-free survival (PFS) and platinum-free interval (PFI) was performed.Results: Germline BRCA1 and BRCA2 mutations were identified in 5 (13%) and 2 (5%) patients, respectively. Somatic genetic alterations were mainly identified in TP53 (97%), BRCA1 (24%), RB1 (21%), FGF23 (21%), CCND2 (18%), RECQL4 (18%) and NF1 (16%). CNVs were comprehensively distributed in 242 genes, with 76% (29/38) of patients harbouring at least one CNV. In addition to BRCA1, somatic genetic alterations were also present in other homologous recombination repair (HRR) genes, including CDK12 (5%), BRCA2 (3%), ATM (3%), BRIP1 (3%), CHEK1 (3%) and FANCI (3%). In total, 22 of 38 (58%) patients had genetic alterations in the HRR pathway. The prognosis analysis indicated that BRCA1/2 mutations were significantly associated with improved PFI (p<0.05) and marginally associated with improved PFS (p=0.05). Patients with R0 resection found positive HRD showing a significant association with better PFI (p<0.05) and a marginal association with better PFS (p=0.06). In patients with NF1 mutation, improved PFS and PFI were observed. However, the difference was not ideal (PFS, p=0.06, PFI, p=0.084). Platinum-sensitivity was significantly associated with BRCA1/2 mutations (p<0.01). Conclusions: In OC patients, genetic mutations frequently occurred in both HRR and non-HRR genes. CNVs are widely present in many genes and patients. Mutational profiling also identified a number of potential therapeutic targets and prognostic markers at the molecular level that could contribute to the personalised treatment and management of OC.
Prevalence of depression and its correlation with anxiety, headache and sleep disorders amongst medical staff in South China
Authors: Lu Guangshuang , Xiao Shaobo , He Jiaji , Xie Wei , Ge Wei , Meng Fanchao , Yang Ying , Yu Shengyuan , Liu Ruozhuo 
Published: May 2022

Abstract
Background: Our previous studies reported the prevalence of primary headache and risk factors among medical staff in South China. The aim of this cross-sectional survey was to learn more about the prevalence of depression in medical staff and its risk factors, as well as to investigate the association between depression, anxiety, headache, and sleep disorders.Methods: Stratified random cluster sampling was used to select medical staff from various departments in four hospitals in Sanya City. Based on previously study, the Self-rating Depression Scale（SDS）, Self-rating Anxiety Scale (SAS), Pittsburgh Sleep Quality Index (PSQI) were used to quantitatively score the depression, anxiety and sleep disorders. Non-parametric Spearman correlation analysis and regression analysis were performed on the factors affecting the occurrence and severity of depression. Results: Among 645 medical staff, 548 (85%) responded. The 1-year prevalence of depression was 42.7% and the prevalence of depression combined with anxiety, headache and sleep disorders was 23%, 27% and 34.5%. The prevalence of depression in females, nurses, unmarried or single group, and rotating-shift population was significantly higher than that in males(48.3% vs 27.1%, OR=2.512), doctors(55.2% vs 26.7%, OR=3.388), married group(50.5% vs 35.8%, OR=1.900), and day-shift population(35.2% vs 7.5%, OR=1.719). The occurrence of depression was correlated with anxiety, sleep disorder, headache and migraine, with anxiety being the most significant (Spearman Rho = 0.531). The SDS was significantly correlated with SAS and PSQI (Spearman Rho = 0.801, 0.503), and also related to the presence of headache and migraine (Spearman Rho = 0.228, 0.159). Multivariate logistic regression indicated that nurse occupation and anxiety were risk factors for depression, while grades of anxiety, sleep disorders and nurse occupation were risk factors for depression degree in multiple linear regression.Conclusion: The prevalence of depression in medical staff is higher than that in the general population especially among females, nurse occupation, unmarried people and rotating-shift population. Depression is associated with anxiety, sleep disorders, headache and migraine. Anxiety and nurse occupation are risk factors for depression. This study might provide a reference for the promotion of occupational health among medical staff.
Gender differences in willingness for childbirth, fertility knowledge, and value of motherhood or fatherhood and their associations among college students in South Korea
Authors: KIM Hae Won , KIM Seo Yun 
Published: May 2022

Abstract
Background
South Korea is a country with a very low fertility rate and there is a tendency for young adults to postpone marriage and childbirth, which affects adverse pregnancy outcomes. It is important for young adults to predict and prepare in advance for future fertility-related issues, especially by identifying their willingness and thoughts about childbirth for both women and men. This study aimed to investigate gender differences in willingness for childbirth, fertility knowledge, and the value of motherhood or fatherhood among college students in South Korea and to explore the factors influencing willingness for childbirth.
Methods
This was a cross sectional study among 286 unmarried college students who were recruited through a campus email and online communities for college student conducted from June 20, 2021 to July 19, 2021. The data were analyzed using the chi-square test and t-test to identify gender differences in general characteristics, willingness for childbirth, fertility knowledge, and value of motherhood of fatherhood. The factors influencing willingness for childbirth were examined using multiple logistic regression.
Results
Female students showed lower willingness for future childbirth than male students (χ2 = 26.85, p < .001). Women valued motherhood significantly less than men valued fatherhood (t = 6.34, p < .001). Women had a lower fertility knowledge score than men (t = 2.53 p = .012). The value of motherhood or fatherhood was an important influencing factor in both male and female college students (AOR = 8.57, 95% CI = 3.79–19.41 and AOR = 10.42, 95% CI = 3.65–29.80, respectively), whereas the monthly allowance was also an important influencing factor in female students (AOR = 1.02, 95% CI = 1.01–1.03).
Conclusions
The findings indicate the future direction to develop effective interventions considering gender differences which will promote healthy pregnancy and childbirth in the future for informed reproductive decision-making for college students.
A Mathematical Model for the Quantification of Pulmonary and Intrapulmonary Arteriovenous Anastomoses Blood Flow
Authors: Vanni Rosalba 
Published: May 2022

Abstract

Objectives: To develop a model for the calculation of pulmonary blood flow (Q̇p) and blood flow through intrapulmonary arteriovenous anastomoses (Q̇IPAVA) under multiple physiological conditions.Methods: A mathematical model was developed into which many experimental physiological parameters were input. Data were obtained simultaneously from arterial blood gases, metabolic measures, and noninvasive measures of cardiac output (Q̇t) in young and healthy men.Results: It was possible to precisely calculate Q̇p and Q̇IPAVA at rest and at moderate (50% of VO2max) and heavy exercise (≥ 90% of VO2max) in both normoxia (FIO2 = 0.2093) and acute hypoxia (FIO2 = 0.125).In normoxia under heavy exercise, Q̇p decreased slightly (97.56% of Q̇t), and Q̇IPAVA represented 2.44% of Q̇t.Instead, in hypoxia at heavy exercise, Q̇p decreased significantly (85.25% of Q̇t), and Q̇IPAVA increased significantly (14.75% of Q̇t), equal to Q̇IPAVA of 3.48 L/min.It was possible to demonstrate a negative contribution of Q̇IPAVA directly to pulmonary gas exchange efficiency.Furthermore, the model immediately identifies incorrect Q̇t measurements.Conclusions: This new mathematical model is precise in calculating Q̇p and Q̇IPAVA.The required data are obtained through noninvasive instruments, which are easy to use and widespread in all hospitals. Q̇p differs significantly from Q̇t under some physiological conditions. The application of this model in the medical field is expected to enable further advancements in scientific research and clinical practice.
Clinical Expression, Prognosis and Immune Infiltration of SUV39H1 in Diffuse Large B-cell Lymphoma
Authors: Zhang Yue , Wen Qing , Lei Ya-Xin , Ge Jing-Jing , Kong Xiao-Shuang , Wang Wen-Hua , Wang Ze-Yuan , Hou Hu-Ting , Qian Si-Yu , Tang Canwei , Wu Shao-Xuan , Wang Guan-Nan , Li Wen-Cai , Zhang Ming-Zhi , Zhang Xu-Dong , Chen Qing-Jiang 
Published: May 2022

Abstract
Epigenetic regulation plays a crucial part in the oncogenesis and treatment of diffuse large B-cell lymphoma (DLBCL). The H3K9me3-specific histone methyltransferase SUV39H1 is a significantly epigenetic gene that promotes the progression of a variety of malignancies. However, the roles of SUV39H1 in DLBCL remain unclear. By retrieving Oncomine, GEPIA, CCLE, UALCAN, and TCGA databases, we observed that the expression of SUV39H1 was higher in DLBCL tissues than in normal and other cancer tissues. Combined with immunohistochemical validation assay, we analysed clinical characteristics of DLBCL patients. The results showed that high expression of SUV39H1 was closely associated with age over 50 years old (P=0.014) and low albumin level (P=0.015). In the prognostic analyses, DLBCL patients in GEPIA database showed that the high SUV39H1 expression group had a lower disease-free survival (DFS) rate than the low SUV39H1 expression group (P=0.035). Finally, we discovered that expressions of CD86+ and CD163+ macrophages have high correlations with SUV39H1+ in DLBCL tissues(with P=0.037 and P=0.045,respectively). SUV39H1-associated macrophages may downregulate T lymphocyte subsets, especially Treg cells in DLBCL(P=0.003). In summary, SUV39H1 might be not only a potential target for the epigenetic therapy and immunotherapy of DLBCL, but also a clinical indicator for doctors to evaluate the trend of disease development.
Scars from protected zero modes and beyond in $U(1)$ quantum link and quantum dimer models
Authors: Biswas Saptarshi , Banerjee Debasish , Sen Arnab 
Published: May 2022

We demonstrate the presence of anomalous high-energy eigenstates, or
many-body scars, in U(1)U(1)
quantum link and quantum dimer models on square and rectangular
lattices. In particular, we consider the paradigmatic Rokhsar-Kivelson
Hamiltonian H=\mathcal{O}_{\mathrm{kin}} + \lambda \mathcal{O}_{\mathrm{pot}}H=𝒪kin+λ𝒪pot
where \mathcal{O}_{\mathrm{pot}}𝒪pot
(\mathcal{O}_{\mathrm{kin}}𝒪kin)
is defined as a sum of terms on elementary plaquettes that are diagonal
(off-diagonal) in the computational basis. Both these interacting models
possess an exponentially large number of mid-spectrum zero modes in
system size at \lambda=0λ=0
that are protected by an index theorem preventing any mixing with the
nonzero modes at this coupling. We classify different types of scars for
|\lambda| \lesssim \mathcal{O}(1)|λ|≲𝒪(1)
both at zero and finite winding number sectors complementing and
significantly generalizing our previous work [Banerjee and Sen, Phys.
Rev. Lett. 126, 220601 (2021)]. The scars at finite
\lambdaλ
show a rich variety with those that are composed solely from the zero
modes of \mathcal{O}_{\mathrm{kin}}𝒪kin,
those that contain an admixture of both the zero and the nonzero modes
of \mathcal{O}_{\mathrm{kin}}𝒪kin,
and finally those composed solely from the nonzero modes of
\mathcal{O}_{\mathrm{kin}}𝒪kin.
These scars have tell-tale energies such as (non-zero) integers and
irrationals like \pm \sqrt{2}±2
at \lambda=0λ=0
or n_1 \lambda \pm n_2n1λ±n2
at \lambda \neq 0λ≠0
where both n_1, n_2n1,n2
are integers. We give analytic expressions for certain ``lego scars’’
for the quantum dimer model on rectangular lattices where one of the
linear dimensions can be made arbitrarily large, with the building
blocks (legos) being composed of emergent singlets and other more
complicated entangled structures.
The Effect of Dissemination Pathways on Uptake and Relative Costs for a Transdiagnostic, Self-guided Internet Intervention for Reducing Depression, Anxiety, and Suicidal Ideation: Comparative Implementation Study
Authors: Batterham Philip J , Gulliver Amelia , Kurz Ella , Farrer Louise M , Vis Christiaan , Schuurmans Josien , Calear Alison L 
Published: May 2022

Background
Self-guided web-based programs are effective; however, inadequate implementation of these programs limits their potential to provide effective and low-cost treatment for common mental health problems at scale. There is a lack of research examining optimal methods for the dissemination of web-based programs in the community.

Objective
This study aimed to compare the uptake, reach, relative costs, and adherence associated with 3 community-based pathways for delivering a low-intensity web-based transdiagnostic mental health program. The 3 dissemination pathways were social media advertising, advertising in general practice, and advertising in pharmacies.

Methods
Participants were recruited on the web, from general practices, or from community pharmacies; completed a screener for psychological distress; and were offered the 4-week FitMindKit program—a 12-module psychotherapeutic intervention. Uptake was defined as the number of participants who enrolled in the web-based program; reach was defined as the rate of uptake per exposure; and costs were calculated based on staff time, equipment, and advertising. Adherence was assessed as the number of modules of FitMindKit completed by the participants.

Results
Uptake comprised 1014 participants who were recruited through the 3 dissemination pathways: on the web (991/1014, 97.73%), in general practice (16/1014, 1.58%), and in pharmacy (7/1014, 0.69%). Reach was highest for social media: 1 in every 50 people exposed to web-based advertising took up the intervention compared with 1 in every 441 in general practitioner clinics and 1 in every 1708 in pharmacies. The dissemination cost was US $4.87 per user on social media, US $557 per user for general practitioner clinics, and US $1272 per user for pharmacy dissemination. No significant differences in adherence were observed between the conditions, whereas all pathways showed an underrepresentation of men and linguistic diversity.

Conclusions
The web-based dissemination pathway was the most efficient and cost-effective for delivering a self-guided internet-based mental health program to people in the community. More research is needed to identify how best to engage men and those with culturally diverse backgrounds in web-based interventions.

Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN12618001688279; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=376113
Dapagliflozin and Kidney Outcomes in Hospitalized Patients with COVID-19 Infection
Authors: Heerspink Hiddo J.L. , Furtado Remo H.M. , Berwanger Otavio , Koch Gary G. , Martinez Felipe , Mukhtar Omar , Verma Subodh , Gasparyan Samvel B. , Tang Fengming , Windsor Sheryl L. , de Souza-Dantas Vicente Cés , del Sueldo Mildren , Frankel Robert , Javaheri Ali , Maldonado Rafael A. , Morse Caryn , Mota-Gomes Marco , Shemin Douglas , Silva Osvaldo Lourenço , Tognon Alexandre Pereira , Twahirwa Marcel , Buenconsejo Joan , Esterline Russell , Oscarsson Jan , Ambery Philip , Langkilde Anna Maria , Kosiborod Mikhail N. 
Published: May 2022

Background and objectives
Patients who were hospitalized with coronavirus disease 2019 (COVID-19) infection are at high risk of AKI and KRT, especially in the presence of CKD. The Dapagliflozin in Respiratory Failure in Patients with COVID-19 (DARE-19) trial showed that in patients hospitalized with COVID-19, treatment with dapagliflozin versus placebo resulted in numerically fewer participants who experienced organ failure or death, although these differences were not statistically significant. We performed a secondary analysis of the DARE-19 trial to determine the efficacy and safety of dapagliflozin on kidney outcomes in the overall population and in prespecified subgroups of participants defined by baseline eGFR.

Design, setting, participants, & measurements
The DARE-19 trial randomized 1250 patients who were hospitalized (231 [18%] had eGFR <60 ml/min per 1.73 m2) with COVID-19 and cardiometabolic risk factors to dapagliflozin or placebo. Dual primary outcomes (time to new or worsened organ dysfunction or death, and a hierarchical composite end point of recovery [change in clinical status by day 30]), and the key secondary kidney outcome (composite of AKI, KRT, or death), and safety were assessed in participants with baseline eGFR <60 and ≥60 ml/min per 1.73 m2.

Results
The effect of dapagliflozin versus placebo on the primary prevention outcome (hazard ratio, 0.80; 95% confidence interval, 0.58 to 1.10), primary recovery outcome (win ratio, 1.09; 95% confidence interval, 0.97 to 1.22), and the composite kidney outcome (hazard ratio, 0.74; 95% confidence interval, 0.50 to 1.07) were consistent across eGFR subgroups (P for interaction: 0.98, 0.67, and 0.44, respectively). The effects of dapagliflozin on AKI were also similar in participants with eGFR <60 ml/min per 1.73 m2 (hazard ratio, 0.71; 95% confidence interval, 0.29 to 1.77) and ≥60 ml/min per 1.73 m2 (hazard ratio, 0.69; 95% confidence interval, 0.37 to 1.29). Dapagliflozin was well tolerated in participants with eGFR <60 and ≥60 ml/min per 1.73 m2.

Conclusions
The effects of dapagliflozin on primary and secondary outcomes in hospitalized participants with COVID-19 were consistent in those with eGFR below/above 60 ml/min per 1.73 m2. Dapagliflozin was well tolerated and did not increase the risk of AKI in participants with eGFR below or above 60 ml/min per 1.73 m2.
Interest and Enthusiasm in Learning English as a foreign Language in a Senior High School in Bangka Belitung Islands, Indonesia and How Both Relate to English Achievement
Authors: Yusriyah Hukama Rizky , Eryansyah Eryansyah , Kurniawan Dedi 
Published: May 2022

Interest and enthusiasm are internal factors known to an extent to have an influence toward learning in general. This study aims at checking these three variables relationship: interest, enthusiasm, and English achievement. It was conducted in Sungai Liat Regency, Bangka Belitung Islands, Indonesia, in a state senior high school which provided 70 students to be the sample of this study from the population of 183 students in the school. The instruments used were: Interest and Enthusiasm Questionnaire and Students’ English score documentation. The data collected using the questionnaire were divided into two parts: interest and enthusiasm. Both data were analyzed using Pearson Product Moment Correlation Coefficient to see the association of interest toward enthusiasm. Furthermore, data from each one of the two variables and combined data from both variables were also analyzed using Pearson Product Moment Correlation Coefficient to find out how both variables as relate toward English achievement. The results show that interest in learning English had a strong significant association toward enthusiasm (r(70)=.77, p=0.00). Furthermore, both interest and enthusiasm had a significant association toward English achievement (respectively: r(70)=.40, p=0.001; r(70)=.24, p=0.046). Moreover, the combination of both interest and enthusiasm also showed a strong association toward English achievement (r(70)=.343, p=0.004). This study also provided some implications and recommendations for further research.
Effect of Distance to Train Station and Mobile Coverage on Land Value: A Case of Tax Valuation in Oreamuno, Costa Rica
Authors: Molina Javier Paniagua , Gómez Sergio Ulate , Thompson Johanna Solórzano , Navarro David Barboza 
Published: May 2022

Abstract
In Costa Rica, a land tax valuation model provided by the Technical Standardization Body (ONT) of the Ministry of Finance is used. This model considers homogeneous areas that include properties with similar characteristics and review factors that have not been recently updated. The objective of this article is to determine the effect of the distance to the train station and mobile coverage on the value of land in Oreamuno, Costa Rica, as a proposal to be included in the mass valuation model of the ONT. A multiple regression econometric model was used to establish the functional relationship between the value of the property and its characteristics, through the Ordinary Least Squares (OLS) method, using 10 variables applied to 200 references initially. The results allow demonstrating that other variables such as “Distance to the train station” and “Mobile coverage” are representative for determining the value of properties, in addition to those commonly used by the ONT model. The research allows concluding that the land valuation models should be updated periodically and should include variables related to improvements in technology and access roads, since these increase the market value of properties and improve the social development of localities in study.
Assessing the risks in food processing to a healthy living environment
Authors: Mijanović Krsto 
Published: May 2022

Abstract
One of the most important environmental factors, which affects the environment of a healthy life is diet. About 75% of new diseases that have occurred since 2000 in the population of Bosnia and Herzegovina have come from animals or products of animal origin. So-called zoonoses are diseases that can be transmitted from animals to humans most often through food. In addition to zoonoses, contamination of soil, water, air and plants also affects, to a large extent, directly or indirectly the environment of a healthy life. Soil, air, water and plants can be contaminated with pollutants such as heavy metals in the soil or dangerous substances that produce certain types of mushrooms, all of which are transferred in many ways to food production processes. The research define the characteristics of a healthy living environment complemented with healthy food, then explain and demonstrate, on appropriate examples, what are the hazards or hazardous places in food production and show how to reduce the likelihood of their occurrence using the standard and applicable regulations.