bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial reporting, debt covenants and convertible debts
Authors: Lau Chee Kwong 
Published: December 2022

PurposeThis study proposes an alternative perspective on why firms issue convertible debt, to supplement the largely theoretical motives identified in the existing literature. It hypothesises that the separate presentation of convertible debt into its equity and liability components has economic consequences and advantage that explain why firms issue convertible over non-convertible debt, consistent with the debt covenant hypothesis. The purpose of this paper is to address the proposed perspective and hypothesis.Design/methodology/approachData on convertible debt, gearing (debt assets and debt equity), debt issuance and retirement, etc. were collected for a sample of 1,104 firms listed on Bursa Malaysia. Regression analyses were then used to assess the hypotheses on how gearing affects the use of convertible debt and the impacts of its use on changes in gearing over the financing cycle.FindingsFirms with higher gearing, and possibly those close to violating debt covenants, are more likely to issue convertible than non-convertible debt. In addition, the use of convertible rather than non-convertible debt both reduces the increase in gearing when debts are issued and leads to a larger decrease in gearing during debt retirements via conversion.Practical implicationsThese effects on gearing provide firms with additional financial flexibility and enhance firms' capacity to borrow more from other sources, a lower-debt advantage.Originality/valueThis study demonstrates the informational role of financial reporting in addressing the stewardship emphasis, as part of the decision usefulness objective of financial reporting in the Conceptual Framework for Financial Reporting.
Disentangling the roles of academic major and gender in determining entrepreneurial intentions among students
Authors: Polin Brian A. 
Published: December 2022

PurposeThe purpose of this research is to compare the levels of EI of male and female students, EI among students of three different academic faculties: business, engineering and nursing and the degree of change in their EI over the course of study. Additionally, the authors set out to isolate and quantify the effects of gender and field of study, independent of each other.Design/methodology/approachThis empirical research is based on a survey of >750 undergraduate college students, in which participants answered a host of Likert-scale questions concerning perceptions of risk, self-efficacy, career path and entrepreneurial intent (EI). The survey also contained a number of demographic questions, including academic field (major) and year of study.FindingsBusiness students express the highest levels of EI, followed by engineering students and nursing students respectively. Regardless of discipline, students become no more or less entrepreneurial over their years of study. Overall, males were found to be significantly more entrepreneurial than females. However, a comparison of males and females within a given faculty yielded almost no differences in EI between the genders.Originality/valueThese findings suggest that students self-select into fields of study based on traits, personalities and interests. It is these same factors that regulate one's EI and not their gender or field of study. Others have analyzed the effects of gender and field of study, the authors isolated the two and analyzed each independently.
Determinants of maternal healthcare-seeking behaviours in Ghana
Authors: Bawuah Alex , Ampaw Samuel 
Published: December 2022

PurposeThis paper aims to explore the determinants of maternal healthcare services (MHS) utilisation in Ghana.Design/methodology/approachIn this paper, logit and negative binomial regressions were used to model data from a recent nationally representative survey (the 2017 Ghana Maternal Health Survey). The analysis is observational, without causal implications. The authors measure MHS utilisation by four indicators: antenatal care (ANC) use, the number of ANC clinic visits, choice of health facility delivery and postnatal care (PNC) use.FindingsAge, parity, education, marital status, wealth, residence and health facilities concentration proved to be significant predictors of MHS use in Ghana. Specifically, older, married and educated women; women of lower parity; those living in urban areas and women from wealthier households were more likely to use MHS. The authors also find that health facilities and personnel predicted higher MHS use. Lastly, women with frequent stillbirths had higher MHS use.Practical implicationsThe results for health facilities and personnel suggest that increasing the supply of health centres and workers may enhance MHS use. The authors conclude that women of lower socio-economic status have worse MHS use, meaning empowering such women might increase such women's MHS use.Originality/valueExisting data suggest falling MHS use in Ghana. Yet, the extant works are based on relatively old data or lack external validity (besides using limited MHS indicators). This paper provides recent and generalisable evidence for public health policies. Additionally, this paper tests the statistical significance of some supply-side factors that have yet to be emphasised in the literature.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-03-2022-0199.
Corporate social responsibility and trade credit: the role of textual features
Authors: Ma Baojun , He Jingxia , Yuan Hui , Zhang Jian , Zhang Chi 
Published: December 2022

Purpose Corporate social responsibility (CSR) is significant in the financial market. Despite plenty of existing research on CSR, few studies have quantified the fine-grained aspects of CSR and examined how diverse CSR aspects are associated with firms' trade credit. Based on the released CSR reports, this paper strives to measure the CSR fulfillment of firms and examine the relationships between CSR and trade credit in terms of textual features presented in these reports.Design/methodology/approach This research proposes a natural language processing-based framework to extract the overall readability and the sentiment of fine-grained aspects from CSR reports, which can signal the performance of firms' CSR in diverse aspects. Furthermore, this paper explores how the textual features are associated with trade credit through partial dependence plots (PDPs), and PDPs can generate both linear and nonlinear relationships.Findings The study’s results reveal that the overall readability of the reports is positively associated with trade credit, while the performance of the fine-grained CSR aspects mentioned in the CSR reports matters differently. The performance of the environment has a positive impact on trade credit; the performance of creditors, suppliers and information disclosure, shows a U-shaped influence on trade credit; while the performance of the government and customers is negatively associated with trade credit.Originality/value This study expands the scope of research on CSR and trade credit by investigating fine-grained aspects covered in CSR reports. It also offers some managerial implications in the allocation of CSR resources and the presentation of CSR reports.
Boosting Foreign Investment: The Role of Certification of Corporate Governance
Authors: BONETTI PIETRO , ORMAZABAL GAIZKA 
Published: December 2022

ABSTRACTThis paper studies the economic consequences of certification of corporate governance practices. For identification, we exploit a recent cross‐country initiative by a coalition of key institutions in Southeast Asia; the periodic publication of a “Top List” of companies in the region selected based on an independent assessment of corporate governance practices. Our results suggest that being included in the list induces an increase in foreign investment and changes in corporate governance practices. The announcement of the Top List elicits a positive stock market response among constituents and is followed by higher accounting performance. Overall, the evidence suggests that the certification of governance practices is a meaningful tool to boost foreign investment.
Enhancement of γ‐aminobutyric acid content in shells of passion fruit (Passiflora edulis) under anoxic vacuum conditions
Authors: Chen Juo‐Yu , Shyu Yuan‐Tay , Wu Sz‐Jie 
Published: December 2022

AbstractPassiflora edulis, commonly known as passion fruit, is a popular all‐weather fruit eaten fresh or processed. Its shells, which currently are mostly discarded as waste and hurt the environment, account for more than half of the passion fruit. The shells contain gamma‐aminobutyric acid (GABA) which is the main inhibitory neurotransmitter and has many proven medical values such as antidepressant, anti‐anxiety, etc. Many studies have shown that GABA production in plants can be significantly increased by reverse stress. Taking Tainong 1 as a typical passion fruit cultivar, this study explored the optimal anoxic vacuum treatment for increasing the GABA content of passion fruit shells. The content increased to 2139.25 ± 26.69 mg/100 g on day 4 of chill storage after vacuum packing (63.68% higher than the control). The activities of glutamate decarboxylase (GAD) and diamine oxidase (DAO) were significantly higher in the vacuum‐treated group than in the control group after 4 days of vacuum‐chill storage. On day 5 of vacuum‐chill storage, the activities of all measured enzymes decreased except for the increase of GABA transaminase (GABA‐T), which was accompanied by a decrease in GABA content. Vacuum treatment and subsequent chill storage increased the content of GABA, thereby increasing functional value of passion fruit shells.
Experimental model of micronodular thymic neoplasm with lymphoid stroma
Authors: Niwa Riko , Hanamatsu Yuki , Kito Yusuke , Saigo Chiemi , Takeuchi Tamotsu 
Published: December 2022

AbstractBackgroundMicronodular thymic neoplasm with lymphoid stroma (MNT), a subtype of thymic tumor, is histopathologically characterized by micronodular thymic epithelial cell nests with lymphoid stroma. Despite the distinct histopathology of MNT, its pathogenesis remains unclear.MethodsIn this study, we aimed to examine a thymic tumor harboring thymic epithelial and lymphoid cells in a nonobese diabetic/severe combined immunodeficiency mouse.ResultsThe excised tumor cells were cultured in vitro and comprised epithelial tumor cells and lymphoid cells. During a three‐dimensional cell culture, the epithelial tumor cells formed micronodular cell nests surrounded by lymphoid stroma. Notably, the lymphoid cells underwent apoptosis when they were separated from the epithelial tumor cells. Cutaneous transplantation of the cultured epithelial cells with splenocytes from BALB/c mice led to tumor formation, and these cells demonstrated a histopathology similar to that of human MNT in a nonobese diabetic/severe combined immunodeficiency mouse.ConclusionGiven its overlapping features with human MNT, the transplanted tumor could serve as an experimental model of this disease.
Effect of three different photosensitizers in photodynamic therapy on bond strength of a calcium silicate‐based sealer to radicular dentin
Authors: Küden Cihan , Karakaş Seda Nur 
Published: December 2022

AbstractTo evaluate the effect of the photodynamic therapy (PDT) using with different photosensitizers on the bond strength of BioRoot RCS (BR) to radicular dentin by comparing with AH Plus (AH). The shaped root canals of 80 human mandibular premolars were divided into four groups based on the final disinfection protocol: NaOCl/EDTA, PDT with methylene Blue (MB), PDT with curcumin (CUR) and PDT with toluidine blue O (TBO) (n = 20). Each group was randomly divided into two subgroups (n = 10), according to the endodontic sealer used for obturation (n = 10). The test of push‐out bond strength (PBS) was performed using an universal test machine. The data were analysed using ANOVA, Tukey post‐hoc, and independent sample t‐test (α = 0.05). MB‐BR group showed the highest PBS at the cervical level (p < 0.05). The selection of the photosensitizer in PDT influenced adhesion of root canal sealers to radicular dentin.
Knowledge sharing on online platforms within organisations: An interactionist perspective on generalised exchange
Authors: Yoshikawa Katsuhiko , Wu Chia‐Huei , Lee Hyun‐Jung 
Published: December 2022

AbstractOrganisations are increasingly introducing online platforms to facilitate knowledge sharing among employees across organisational boundaries. Nonetheless, individuals do not always share knowledge on such platforms. This study aims to identify the factors that can motivate individuals to share knowledge on an online platform drawing on social exchange theory and the idea of generalised exchange, a form of social exchange identified on online knowledge‐sharing platforms in previous studies. Specifically, we propose that individuals are more likely to share knowledge on online platforms when they have requests from an employee with whom they have worked in the same office in the past but do not currently work in the same office location (i.e. past‐collocation history), have high levels of generalised exchange orientation, and need to use a wide variety of knowledge to complete their jobs (i.e. knowledge variety). Using a longitudinal dataset spanning 6 months among 100 users on an in‐house online platform of a professional service firm, we find support for the three‐way interaction hypothesis in a three‐level analysis. We discuss implications on knowledge sharing on in‐house online platforms.
City building knowledge from neighbourhoods in Asia Pacific
Authors: Padawangi Rita , Ho K. C. , Yun Hae Young , Rabé Paul 
Published: December 2022

AbstractNeighbourhoods are places of social encounters on a daily basis, but they are getting insufficient attention from policy makers and urban studies in conceptualising the city. While the city is often the unit of analysis and boundaries of data collection, social constructions of the city are mostly from neighbourhoods. By shifting the analysis to the neighbourhood scale, we are moving scholarship and research on two fronts. First, we need to think about city building knowledge at a pedagogical and methodological level. Second, we want to examine processes and amenity creation at the neighbourhood scale and make visible the ways these add to city politics, economy, and culture. Articles in this special issue contribute to urban scholarship in the following ways: (i) neighbourhood as a method of urban studies; (ii) understanding urban politics and government; (iii) the role of urban informality and small businesses; and (iv) the role of traditional neighbourhood institutions in the social life of the city. Neighbourhoods can be poorly resourced and inward‐looking, but in many cases localised interests, relationships and organisations are capable of collective action, networking beyond their localities, and inspiring its residents with aspirations of the city's future directions.
Lidocaine alleviates inflammation and pruritus in atopic dermatitis by blocking different population of sensory neurons
Authors: Sun Pei‐Yi , Li Hua‐Guo , Xu Qian‐Yue , Zhang Zhen , Chen Jia‐Wen , Shen Yi‐Hang , Qi Xin , Lu Jian‐Fei , Tan Yi‐Dong , Wang Xiao‐Xiao , Li Chun‐Xiao , Yang Meng‐Ying , Ma Yu‐Zhi , Lu Ying , Xu Tian‐Le , Shen Jin‐Wen , Li Wei‐Guang , Guo Yi‐Feng , Yao Zhi‐Rong 
Published: December 2022

AbstractBackground and PurposeAtopic dermatitis is a common chronic pruritic inflammatory disease of the skin involving neuro‐immune communication. Neuronal mechanism‐based therapeutic treatments remain lacking. We investigated the efficacy of intravenous lidocaine therapy on atopic dermatitis and the underlying neuro‐immune mechanism.Experimental ApproachPharmacological intervention, immunofluorescence, RNA‐sequencing, genetic modification and immunoassay were performed to dissect the neuro‐immune basis of itch and inflammation in atopic dermatitis‐like mouse model and in patients.Key ResultsLidocaine alleviated skin lesions and itch in both atopic dermatitis patients and calcipotriol (MC903)‐induced atopic dermatitis model by blocking subpopulation of sensory neurons. QX‐314, a charged NaV blocker that enters through pathologically activated large‐pore ion channels and selectivity inhibits a subpopulation of sensory neurons, has the same effects as lidocaine in atopic dermatitis model. Genetic silencing NaV1.8‐expressing sensory neurons was sufficient to restrict cutaneous inflammation and itch in the atopic dermatitis model. However, pharmacological blockade of TRPV1‐positive nociceptors only abolished persistent itch but did not affect skin inflammation in the atopic dermatitis model, indicating a difference between sensory neuronal modulation of skin inflammation and itch. Inhibition of activity‐dependent release of calcitonin gene‐related peptide (CGRP) from sensory neurons by lidocaine largely accounts for the therapeutic effect of lidocaine in the atopic dermatitis model.Conclusion and ImplicationsNaV1.8+ sensory neurons play a critical role in pathogenesis of atopic dermatitis and lidocaine is a potential anti‐inflammatory and anti‐pruritic agent for atopic dermatitis. A dissociable difference for sensory neuronal modulation of skin inflammation and itch contributes to further understanding of pathogenesis in atopic dermatitis.
Special AT‐rich sequence binding protein 1 promotes multidrug resistance in gastric cancer by regulation of Ezrin to alter subcellular localization of ATP‐binding cassette transporters
Authors: Luo Jiajun , Yuan Jingwen , Yang Yu , Jiang Yue , Yan Junfeng , Tong Qiang 
Published: December 2022

AbstractMultidrug resistance is a primary factor in the poor response to chemotherapy and subsequent death in gastric cancer patients. However, the molecular mechanisms involved remain unclear. In this study, the high expression of special AT‐rich sequence binding protein 1 (SATB1) in gastric cancer was found to be associated with reduced sensitivity to various chemotherapy drugs. Our results demonstrate that SATB1 can promote chemotherapy resistance in gastric cancer in vitro and in vivo. SATB1 exerts its effect by enhancing the activity of multiple ATP‐binding cassette (ABC) transporters (P‐glycoprotein, multidrug resistance‐associated protein, and breast cancer resistance protein) in gastric cancer cell lines. We also found that SATB1 affects ABC transporters by altering the subcellular localization of the ABC transporter rather than its expression. Subsequently, we confirmed that Ezrin binds to various ABC transporters and affects their subcellular localization. In addition, we found that SATB1 can also bind to the Ezrin promoter and regulate its expression. In the present study, we elucidate the mechanism of SATB1‐mediated multidrug resistance in gastric cancer, providing a basis for SATB1 as a potential target for reversal of resistance.
Comparison of 4‐ or 6‐implant supported immediate full‐arch fixed prostheses: A retrospective cohort study of 217 patients followed up for 3–13 years
Authors: Zhang Yan , Li Sha , Di Ping , Zhang Yu , Wu Aozhou , Lin Ye 
Published: December 2022

AbstractPurposeChoosing four or six implants to support immediate full‐arch fixed prostheses (FAFPs) is still controversial worldwide. This study aims to analyze and compare the long‐term results of All‐on‐4 and All‐on‐6.Materials and MethodsThis retrospective cohort study enrolled 217 patients rehabilitated with 1222 implants supporting 271 FAFPs, including 202 prostheses supported by 4 implants (All‐on‐4 group) and 69 prostheses supported by 6 implants (All‐on‐6 group), and followed up for 3–13 years. Implant survival, prosthesis survival, complications, and implant marginal bone loss (MBL) were evaluated and compared between two groups. Patient characteristics including age, gender, jaw, opposite dentition condition, smoking habit, bruxism, bone quantity and quality, cantilever length (CL), prosthesis material, and oral hygiene were analyzed to assess their influence on the clinical results of the two groups. Six surgeons and three prosthodontists who performed FAFPs more than 5 years were invited for questionnaires, to assess patient‐ and clinician‐related influences on implant number.ResultIn general, All‐on‐4 group indicated no significant difference with All‐on‐6 group in the implant survival (implant‐level: hazard ratio [HR] = 1.0 [95% confidence interval (CI): 0.8–1.2], P = 0.96; prosthesis‐level: HR = 0.8 [95% CI: 0.3–1.8], P = 0.54), prosthesis survival (odds ratio [OR] = 0.8 [95% CI: 0.3–2.8], P = 0.56), biological complications (OR = 0.9 [95% CI: 0.5–1.8], P = 0.78), technical complications of provisional prosthesis (OR = 1.3 [95% CI: 0.7–2.3], P = 0.42), technical complications of definitive prosthesis (OR = 1.1 [95% CI: 0.6–2.2], P = 0.33) and the 1st, 5th, and 10th year MBL (P = 0.65, P = 0.28, P = 0.14). However, for specific covariates, including elderly patients, opposing natural/fixed dentition, smoking, bruxism, long CL, low bone density, and all acrylic provisional prostheses, All‐on‐6 was more predictable in some clinical measurements than All‐on‐4. The implant prosthodontists and the medium‐experienced clinicians showed significant preference for All‐on‐6 (P < 0.05).ConclusionBased on this study, the long‐term clinical results showed no significant difference between All‐on‐4 and All‐on‐6 groups in general. However, for some specific characteristics, All‐on‐6 seemed to be more predictable in some clinical measurements than All‐on‐4. For the clinicians' decision‐making, medium‐experienced clinicians and the implant prosthodontists showed significant preference for All‐on‐6.
Chemokine receptor 7 mediates miRNA‐182 to regulate cerebral ischemia/reperfusion injury in rats
Authors: Wang Qi , Xu Sifan , Wang Bin , Qin Yu , Ji Yachen , Yang Qian , Xu Yang , Zhou Zhiming 
Published: December 2022

AbstractAimsChemokine receptor 7 (CXCR7) exerts protective effects on the brain. MicroRNAs (miRNAs) are involved in cerebral ischemia/reperfusion (I/R) injury, but their involvement in CXCR7‐mediated brain protection is unknown. In this study, we investigated the role of miRNAs in CXCR7‐mediated brain protection.MethodsCXCR7 levels in peripheral blood samples from patients with acute ischemic stroke (AIS) and ischemic penumbra area brain tissues from middle cerebral artery occlusion (MCAO) rats after recanalization were measured. An miRNA microarray analysis was performed to examine the expression of miRNAs caused by CXCR7 knockdown in ischemic penumbra area brain tissue in middle cerebral artery occlusion–reperfusion rats and to predict corresponding downstream target genes. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed the most enriched pathways. A dual‐luciferase reporter assay confirmed the direct regulation of miR‐182 on the target gene TCF7L2. The correlation between TCF7L2 and CXCR7/miR‐182 was verified using rescue assays.ResultsCXCR7 expression was upregulated in MCAO rats and mechanical thrombectomy patients with AIS compared to that in controls. The motor and sensory functions of MCAO rats with CXCR7 knockdown further decreased, and the infarct volume and cerebral edema increased. miRNA microarray data showed that seven miRNAs were differentially expressed after shRNA‐CXCR7 treatment. The dual‐luciferase reporter assay confirmed that miR‐182 directly targeted the TCF7L2 gene. Rescue assays confirmed that TCF7L2 is downstream of CXCR7/miR‐182. KEGG pathway analysis showed that the Hippo pathway may be a key pathway in CXCR7 upregulation and plays a role in protecting the brain after interventional surgery. Animal experiments have shown that CXCR7‐mediated cerebral I/R injury promotes the phosphorylation of key molecules YAP and TAZ in the Hippo pathway.ConclusionCXCR7 protects against cerebral I/R injury, possibly via the miR‐182/TCF7L2/Hippo pathway. These results indicate that CXCR7 affects cerebral ischemia–reperfusion injury through miRNA regulation and downstream pathways.