bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-clinical investigation of astatine-211-parthanatine for high-risk neuroblastoma
Authors: Makvandi Mehran , Samanta Minu , Martorano Paul , Lee Hwan , Gitto Sarah B. , Patel Khushbu , Groff David , Pogoriler Jennifer , Martinez Daniel , Riad Aladdin , Dabagian Hannah , Zaleski Michael , Taghvaee Tara , Xu Kuiying , Lee Ji Youn , Hou Catherine , Farrel Alvin , Batra Vandana , Carlin Sean D. , Powell Daniel J. , Mach Robert H. , Pryma Daniel A. , Maris John M. 
Published: November 2022

AbstractAstatine-211-parthanatine ([211At]PTT) is an alpha-emitting radiopharmaceutical therapeutic that targets poly(adenosine-diphosphate-ribose) polymerase 1 (PARP1) in cancer cells. High-risk neuroblastomas exhibit among the highest PARP1 expression across solid tumors. In this study, we evaluated the efficacy of [211At]PTT using 11 patient-derived xenograft (PDX) mouse models of high-risk neuroblastoma, and assessed hematological and marrow toxicity in a CB57/BL6 healthy mouse model. We observed broad efficacy in PDX models treated with [211At]PTT at the maximum tolerated dose (MTD 36 MBq/kg/fraction x4) administered as a fractionated regimen. For the MTD, complete tumor response was observed in 81.8% (18 of 22) of tumors and the median event free survival was 72 days with 30% (6/20) of mice showing no measurable tumor >95 days. Reversible hematological and marrow toxicity was observed 72 hours post-treatment at the MTD, however full recovery was evident by 4 weeks post-therapy. These data support clinical development of [211At]PTT for high-risk neuroblastoma.
Influence of a mass transfer stability criterion on double white dwarf populations
Authors: Zhenwei Li , Xuefei Chen , Hongwei Ge , Hai-Liang Chen , Zhanwen Han 
Published: November 2022

Context. Mass transfer stability is a key issue in studies of binary evolution. Critical mass ratios for dynamically stable mass transfer have been analyzed on the basis of an adiabatic mass loss model, finding that the donor stars on the giant branches tend to be more stable than that based on the composite polytropic stellar model. Double white dwarfs (DWDs) are of great importance in many fields and their properties would be significantly affected under the new mass transfer stability criterion.
Aims. We seek to investigate the influence of mass transfer stability on the formation and properties of DWD populations and discuss the implications in supernova Type Ia (SN Ia) and gravitational wave (GW) sources.
Methods. We performed a series of binary population synthesis, adopting the critical mass ratios from the adiabatic mass loss model (i.e., Ge’s model) and that of the composite polytropic model, respectively. In each simulation, 5 × 106 binaries were included and evolved from zero-age main sequence to the end of their evolution and the DWDs were gradually obtained.
Results. For Ge’s model, most of the DWDs are produced from the stable non-conservative Roche lobe (RL) overflow, along with a common-envelope (CE) ejection channel (RL+CE channel), regardless of the CE ejection efficiency, αCE. Conversely, the results of the polytropic model strongly depend on the adopted value of αCE. We find DWDs produced from the RL+CE channel have comparable WD masses and the mass ratio distribution peaks at around 1. Based on the magnitude-limited sample of DWDs, the space densities for the detectable DWDs and those with extremely low-mass WD (ELM WD) companions in Ge’s model is: 1347 kpc−3 and 473 kpc−3, respectively, which is close to what has been shown in observations. On the other hand, the polytropic model overpredicts space density of DWDs by a factor of about 2−3. We also find that the results of DWD merger rate distribution per Galaxy in Ge’s model reproduce the observations better than that of the polytropic model, and the merger rate of DWDs with ELM WD companions in the Galaxy is about 1.8 × 10−3 yr−1 in Ge’s model. This result is comparable to the observation estimation of 2 × 10−3 yr−1. The findings from Ge’s model predict a Galactic SN Ia rate of ∼6 × 10−3 yr−1 from DWDs, supporting observations of (5.4 ± 1.2)×10−3 yr−1. For the fiducial model of αCE = 1, the number of detectable GW sources in the polytropic model is larger than that in Ge’s model by about 35%.
Conclusions. We confirm that mass transfer stability plays an important role in the formation and properties of DWD populations as well as in the progenitors of SNe Ia and detectable GW sources. The results of Ge’s model support the observational DWD merger rate distribution per Galaxy and the space density of DWDs in the Galaxy.
Tuberkulose im Erwachsenenalter
Authors: Schaberg Tom , Brinkmann Folke , Feiterna-Sperling Cornelia , Geerdes-Fenge Hilte , Hartmann Pia , Häcker Brit , Hauer Barbara , Haas Walter , Heyckendorf Jan , Lange Christoph , Maurer Florian P. , Nienhaus Albert , Otto-Knapp Ralf , Priwitzer Martin , Richter Elvira , Salzer Helmut J.F. , Schoch Otto , Schönfeld Nicolas , Stahlmann Ralf , Bauer Torsten 
Published: November 2022

ZusammenfassungDie Tuberkulose ist in Deutschland eine seltene, überwiegend gut behandelbare Erkrankung. Weltweit ist sie eine der häufigsten Infektionserkrankungen mit ca. 10 Millionen Neuerkrankungen/Jahr. Auch bei einer niedrigen Inzidenz in Deutschland bleibt Tuberkulose insbesondere aufgrund der internationalen Entwicklungen und Migrationsbewegungen eine wichtige Differenzialdiagnose. In Deutschland besteht, aufgrund der niedrigen Prävalenz der Erkrankung und der damit verbundenen abnehmenden klinischen Erfahrung, ein Informationsbedarf zu allen Aspekten der Tuberkulose und ihrer Kontrolle. Diese Leitlinie umfasst die mikrobiologische Diagnostik, die Grundprinzipien der Standardtherapie, die Behandlung verschiedener Organmanifestationen, den Umgang mit typischen unerwünschten Arzneimittelwirkungen, die Besonderheiten in der Diagnostik und Therapie resistenter Tuberkulose sowie die Behandlung bei TB-HIV-Koinfektion. Sie geht darüber hinaus auf Versorgungsaspekte und gesetzliche Regelungen wie auch auf die Diagnosestellung und präventive Therapie einer latenten tuberkulösen Infektion ein. Es wird ausgeführt, wann es der Behandlung durch spezialisierte Zentren bedarf.Die Aktualisierung der S2k-Leitlinie „Tuberkulose im Erwachsenenalter“ soll allen in der Tuberkuloseversorgung Tätigen als Richtschnur für die Prävention, die Diagnose und die Therapie der Tuberkulose dienen und helfen, den heutigen Herausforderungen im Umgang mit Tuberkulose in Deutschland gewachsen zu sein.
Ein Schritt ins Dunkle: Pilotstudie zu Prävalenz, situativem
Kontext und Folgen sexualisierter Gewalt gegen Kinder und Jugendliche in
Deutschland
Authors: Hoell Andreas , Kourmpeli Eirini , Dölling Dieter , Horten Barbara , Meyer-Lindenberg Andreas , Dreßing Harald 
Published: November 2022

Zusammenfassung
Ziel der Studie war die Erfassung des Ausmaßes sexualisierter
Gewalt gegen Kinder und Jugendliche, der unterschiedlichen Tatkontexte und
Folgen sexualisierter Gewalt.
Methodik Es wurde eine Zufallsstichprobe aus einer städtischen
Bevölkerung (18–69 Jahre) erhoben, die zum aktuellen
Wohlbefinden, zu Hilfsangeboten für Kinder und Jugendliche bei
sexualisierter Gewalt und zu Erfahrungen mit sexualisierter Gewalt im Kindes-
und Jugendalter mittels einer Hybridumfrage befragt wurden.
Ergebnisse Der Rücklauf betrug n=159 (17,3%). Es
gaben 18,2% an, mindestens einmal in der Kindheit oder Jugend Opfer
sexualisierter Gewalt geworden zu sein. Davon berichteten 34,5% zum
ersten Mal von diesen Ereignissen. Das psychische Wohlbefinden war in der Gruppe
der von sexualisierter Gewalt Betroffenen signifikant geringer. Die Kenntnis zu
Hilfsangeboten war bei allen Teilnehmenden eher gering.
Schlussfolgerung Die gewählte Methode ließe sich im Rahmen
einer bundesweiten repräsentativen Befragung anwenden, um Einblicke in
das Dunkelfeld der sexualisierten Gewalt zu geben.
Agents Used for Nerve Blocks and Neurolysis
Authors: Wu Richard , Majdalany Bill S. , Lilly Meghan , Prologo J. David , Kokabi Nima 
Published: November 2022

AbstractThe recognition of pain and the treatments used for it are vital for all practitioners. Many types of pain can be treated in a locoregional fashion, which has significant implications not just for any individual patient but for society as a whole. These treatments are most effective when performed in a minimally invasive, image-guided fashion. Interventional radiologists should play a central role in providing these lifestyle-limiting treatments. This article describes the medications most typically used for spinal and extra-axial treatments in the management of patients in pain.
Nononcologic Embolization
Authors: De la Garza-Ramos Cynthia , Salei Aliaksei , Caridi Theresa M. 
Published: November 2022

AbstractThe scope of conditions managed by embolization, which was initially used for the treatment of hemorrhage and vascular malformations, is constantly expanding. Apart from oncologic indications, embolization is used to treat a wide range of benign pathology, including uterine fibroids and benign prostatic hyperplasia. While various particulate embolic agents are successfully used for benign embolization, there is growing evidence that unique properties of these may result in different outcomes. This article reviews available evidence comparing various particles used for uterine fibroid embolization and prostate artery embolization. In addition, we provide an overview of periprocedural pharmacology and protocols facilitating same-day discharge for these interventions.
Antibiotics Tubes and Lines
Authors: Khurana Navpreet , Salei Aliaksei , Gunn Andrew J. , Huang Junjian 
Published: November 2022

AbstractAntibiotic prophylaxis in interventional radiology (IR) is widely used; however, such practice is based on data from the surgical literature. Although published guidelines can help determine the need for prophylactic antibiotic use in the patient undergoing percutaneous procedures, local practice patterns often dictate when such medications are given. In this article, the current state of periprocedural antibiotic use in commonly performed IR procedures (i.e., tube and catheter placements) is presented.
Correcting Coagulopathy for Image-Guided Procedures
Authors: Novelli Paula M. , Tublin Joshua M. , Orons Philip D. 
Published: November 2022

AbstractPatients with acquired coagulopathy often require percutaneous image-guided invasive procedures for urgent control of hemorrhage or for elective procedures. Routine preprocedural evaluation of coagulopathy previously focused on absolute prothrombin time, partial thromboplastin time, international normalized ratio, and platelet count values. Now viscoelastic testing and greater understanding of patient- and drug-specific changes in coagulation profiles can yield better coagulation profile data. More specific reversal agents and profiles combine for less generalized and more titrated transfusion or correction algorithms. This article reviews procedural and patient-specific factors for defining both hemorrhagic risk and correction strategies.
Reading
Authors: Elgort Irina 
Published: November 2022

Abstract
What is involved in skilled reading and learning to read in a second language (L2), compared with the first language (L1)? Answers to this question can shape our thinking about what needs to be taught and investigated in instructed second language acquisition of reading by learners already literate in their L1s. Reading comprehension is a complex cognitive task that is notoriously difficult to define and measure (Nation & Waring, 2019), and building on relevant research paradigms and methods from adjacent fields offers a way to address this complexity. In this chapter, I consider interdisciplinary methodological approaches used to study reading that ISLAR researchers can adopt and adapt in investigating learning to read and reading to learn in an additional language. The chapter concludes with a detailed look at selected studies exemplifying the use of such research methods and advice for future L2 reading researchers.
Speaking
Authors: Kuiken Folkert , Vedder Ineke 
Published: November 2022

Abstract
This chapter focuses on the assessment of oral performance in a second language (L2), viewed from the perspective of task-based language assessment and instructed second language acquisition. The notion of L2 proficiency, as presented in the Common European Framework of References (Council of Europe, 2001), rests on two pillars that have to be taken into account when measuring L2 speaking: (1) the linguistic dimension, referring to the complexity, accuracy, and fluency (CAF) of the speaker’s utterances; and (2) the communicative dimension, concerning the appropriateness and effectiveness of the message to be conveyed, labeled functional adequacy (FA). Whereas the majority of studies on the assessment of learner performance have focused on CAF, little attention has been devoted to the functional aspects of L2 performance. The rationale underlying the present chapter is that assessing L2 speaking is impossible without considering both CAF and FA (henceforth, CAFFA) and the mutual relationship between the two constructs. It is argued that L2 speaking should not only be assessed by measures along the CAF-triad but also in terms of FA. The chapter discusses the theoretical underpinnings and applicability of a rating scale for FA (Kuiken & Vedder, 2017, 2018).
Some grammatical features of Faifi Arabic with a focus on emphatic fricatives
Authors: Alfaifi Abdullah , Davis Stuart 
Published: November 2022

Abstract
After overviewing some unusual features of Faifi Arabic, the present study investigates the distribution of emphatic fricatives in a subvariety of Faifi Arabic (FA) focusing on their unique realizations. First, we observe that the emphatic /sˤ/, which is cognate with Classical Arabic /sˤ/, is typically realized as [st] in FA. Second, FA emphatic fricative /ðˤ/ is affected by a process of root-initial devoicing, whether it is cognate with Classical Arabic /ðˤ/ or /dˤ/. When root-initial /ðˤ/ is cognate with Classical Arabic /ðˤ/ and low vowels occur in the first two syllables, the emphatic devoices, resulting in the surface allophone [θˤ]; if a high vowel is present, the emphatic also depharyngealizes, resulting in [θ]. When FA root-initial /ðˤ/ is cognate with Classical Arabic /dˤ/, it typically surfaces as labiodental fricative [f]; otherwise, it is realized as [ðˤ].
Phraseological complexity in EFL learners’ spoken production across proficiency levels
Authors: Paquot Magali , Gablasova Dana , Brezina Vaclav , Naets Hubert 
Published: November 2022

Abstract
This study explores phraseological complexity in English as a Foreign Language (EFL) learners’ spoken production across proficiency levels in the Trinity Lancaster Corpus. Phraseological diversity and sophistication are operationalized as root type-token ratios and median mutual information scores of verb + object co-occurrences respectively. Results draw a complex picture of phraseological complexity in EFL learners’ oral performance, with phraseological diversity increasing on the whole and phraseological sophistication decreasing significantly from B1 to B2. These findings can at least partly be explained by the fact that, unlike EFL learners at B1, EFL learners at B2 and above repeat fewer combinations and use more specific vocabulary, which sometimes leads to less idiomatic combinations that should nevertheless be considered as traces of qualitative development.
Persistent errors in spoken English among Taiwanese and Czech learners at CEFR B2 and C1
Authors: Gráf Tomáš , Huang Lan-Lanfen 
Published: November 2022

Abstract
The study provides empirical evidence illustrating the development of grammatical accuracy in spoken learner English from CEFR’s B2 to C1 levels of accuracy. It uses the CEFR-rated and error-tagged Taiwanese and Czech sub-corpora of LINDSEI containing altogether 54 B2 and 36 C1 speakers. The analysis of the 5,120 identified errors revealed a threefold increase in accuracy at the C1 level. However, some errors which might be labelled persistent were identified, namely errors in some aspects of the use of articles and errors in the use of some verb tenses. The study contributes to the discussion of criterial features for proficiency levels.
Accuracy, syntactic complexity and task type at play in examination writing
Authors: Lyashevskaya Olga , Vinogradova Olga , Scherbakova Anna 
Published: November 2022

Abstract
This chapter explores the association between syntactic complexity and syntactic accuracy in essays written by Russian learners of English in reply to two examination task types: a description of graphical material (Task 1) and an opinion essay (Task 2). A Poisson regression model served to predict the number of syntactic errors. Two syntactic complexity parameters were statistically significant in predicting syntactic accuracy in both tasks: the numbers of sentences and adverbial clauses. Three more parameters predicted the accuracy in Task 1 only: maximum depth of syntactic trees, and the numbers of adjective + noun and noun + infinitive constructions. Six parameters were related to syntactic accuracy in Task 2: the numbers of all clauses, of tokens and of T- units; the average length of sentence; and the numbers of coordinated and of participle + noun constructions.
Exploring the use of repeats in learners’ native and interlanguage production
Authors: Larsson Aas Hege , Rørvik Sylvi 
Published: November 2022

Abstract
This chapter investigates repeats in native language (L1) Norwegian and interlanguage (IL) English, with the aim of exploring interlanguage fluency variations and the potential existence of individual speaking styles across both L1 and IL production. We manually identified and categorized repeats in six interviews from the (forthcoming) Norwegian component of the LINDSEI corpus (Gilquin et al. 2010) and interviews with the same speakers in their L1. Our results show that repeats occur more frequently in the IL, but there is also evidence of individual variation in speaking styles. We conclude by suggesting some pedagogical implications of our results as related to the teaching and assessment of fluency behavior, emphasizing individual cross-linguistic behavior in the face of processing difficulties.
On the application of the Mitscherlich-Baule equation to fertiliser response data
Authors: Dhanoa M.S. , Sanderson R. , Cardenas L.M. , Shepherd A. , Chadwick D.R. , Powell C.D. , Ellis J.L. , López S. , France J. 
Published: November 2022

Abstract
The application of the Mitscherlich-Baule equation to fertiliser response data from an extant experiment conducted in New Zealand is further investigated. An estimate of the relevant soil nutrient is obtained as a function of the fitted parameter values using a full model. Estimates of the Baule units are given. These also depend on the fitted parameters. Additionally, predicted estimates of asymptotes are compared with their fitted estimates. Thus, our primary purpose is to describe additional facets of using a Mitscherlich response function to fit crop yield data. We believe the extra results obtained enhance the value of crop growth experiments.
Key comparison BIPM.RI(I)-K2 of the air-kerma standards of the ARPANSA, Australia, and the BIPM in low-energy x-rays
Authors: Burns D T , Kessler C , Butler D , Shoyookhi S , Hanlon M 
Published: November 2022

Main text
A key comparison has been made between the air-kerma standards of the ARPANSA, Australia, and the BIPM in the low-energy x ray range. The results show the standards to agree at the level of the expanded uncertainty of the comparison of 9 parts in 103 (22 parts in 103 at 10 kV). The results are analysed and presented in terms of degrees of equivalence, suitable for entry in the BIPM key comparison database.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
APMP.M.H-S5 final report of the supplementary comparison of Brinell hardness
Authors: Pakkratoke Montree , Sasom Nitiwat , Hattori Koichiro , Tak Nae Hyung 
Published: November 2022

Main text
This report purposed the results of supplementary comparison of Brinell hardness, APMP.M.H-S5, among three National Metrology Institutes (NIMT, NMIJ/AIST and KRISS). The comparison was carried out during April 2018 to July 2019 in order to determine the capability of the primary Brinell hardness standard, including standard conditions, of each participant, to confirm the accuracy of Brinell hardness scale HBW 10/500 and HBW 10/3000 measurement declared by each participant, which includes the effect of each participant's primary indenter, and determine the degrees of equivalence of hardness scale measurement in the range 45HBW to 550HBW. The pilot institute was the National Institute of Metrology (Thailand), NIMT. There were 2 different types of artifacts for the comparison. The first set was the set of Brinell hardness comparison: hardness measurement. The second set is a set of diameter length comparison: diameter length measurement.
The measurement results of each participant were used to compute the degree of equivalence in comparison reference value (CRV) and the uncertainty of this deviation at a 95% level of confidence. The En number was calculated to express the equivalence between the measurements of participants as well.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Dipole responses in γ−soft 124–134Xe in the spectroscopic energy region
Authors: Quliyev H , Guliyev E , Kuliev A A 
Published: November 2022

Abstract
This study aimed to systematically investigate the low-lying dipole states of even–even 124–134Xe isotopes using the quasiparticle random phase approximation method. Where in all the studied xenon isotopes, electric and magnetic dipole responses were clearly predicted. The calculations predict mainly a scissors mode, while the strength of weakly deformed 132, 134Xe was small compared to moderately deformed 124–130Xe isotopes, where electric dipole excitations make their own contributions as well. The obtained results are consistent with the available experimental data. Since it was not possible to experimentally determine the parity of dipole states here through a comparison of our results with the experiment, we investigated the role of electric and magnetic dipole excitations in forming the spectrum. After comparing the obtained results with the experimentally derived ones, the natures of several observed spin- and parity-unknown excitations were determined.