bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usability testing of a wireless individual indicator system application: Monitoring exposure to outdoor air pollution among Malaysian Traffic Police
Authors: Mohamad Jamil Putri Anis Syahira , Karuppiah Karmegam , Mohammad Yusof Nur Athirah Diyana , Mohd Suadi Nata Dayana Hazwani , Abdul Aziz Nurhanim , How Vivien , Mohd Tamrin Shamsul Bahri , Naeni Hassan Sadeghi 
Published: May 2022

Objectives Designs for low-cost air monitors and associated performance data appear in many peer-reviewed articles; however, few manuscripts provide feedback from end user's experiences or comprehensive evaluation. The present study addresses the usability of the wireless outdoor individual exposure indicator system from the viewpoint of the Malaysian Traffic Police (end users). This study is one of the first to chronicle end user experiences for low-cost pollution sensing. Method The evaluation involved 12 target end users to assess the usability of a prototype for Malaysian Traffic Police to manage their exposure to outdoor air pollution. The test evaluation includes a pre-test, post-task and post-test questionnaire (Post-Study System Usability Questionnaire). The main components in this Post-Study System Usability Questionnaire are Overall satisfaction, System Usefulness, Information Quality and Interface Quality. Findings The results of the Post-Study System Usability Questionnaire indicated the mean score of the Overall satisfaction item (2.33), System Usefulness (2.25), Information Quality (2.36) and Interface Quality (2.17) on a scale of 1–10. Prototype users were satisfied with the system because the score is close to 1 on the Post-Study System Usability Questionnaire. Conclusions A user-friendly wireless outdoor individual exposure indicator system is now available for Malaysian Traffic Police. Users have stated that they are happy to use the system at work. However, in addition to more technological advances, practical implementation requires evidence supporting its efficacy, viability and effectiveness.
Influence of the Anteromedial Portal and Transtibial Drilling Technique on Femoral Tunnel Lengths in ACL Reconstruction: Results Using an MRI-Based Model
Authors: Dimitriou Dimitris , Cheng Rongshan , Yang Yangyang , Helmy Naeder , Tsai Tsung-Yuan 
Published: May 2022

Background: In anatomic anterior cruciate ligament (ACL) reconstruction, graft placement through the anteromedial (AM) portal technique requires more horizontal drilling of the femoral tunnel as compared with the transtibial (TT) technique, which may lead to a shorter femoral tunnel and affect graft-to-bone healing. The effect of coronal and sagittal femoral tunnel obliquity angle on femoral tunnel length has not been investigated. Purpose: To compare the length of the femoral tunnels created with the TT technique versus the AM portal technique at different coronal and sagittal obliquity angles using the native femoral ACL center as the starting point of the femoral tunnel. The authors also assessed sex-based differences in tunnel lengths. Study Design: Descriptive laboratory study. Methods: Magnetic resonance imaging scans of 95 knees with an ACL rupture (55 men, 40 women; mean age, 26 years [range, 16-45 years]) were used to create 3-dimensional models of the femur. The femoral tunnel was simulated on each model using the TT and AM portal techniques; for the latter, several coronal and sagittal obliquity angles were simulated (coronal, 30°, 45°, and 60°; sagittal, 45° and 60°), representing the 10:00, 10:30, and 11:00 clockface positions for the right knee. The length of the femoral tunnel was compared between the techniques and between male and female patients. Results: The mean ± SD femoral tunnel length with the TT technique was 40.0 ± 6.8 mm. A significantly shorter tunnel was created with the AM portal technique at 30° coronal/45° sagittal (35.5 ± 3.8 mm), whereas a longer tunnel was created at 60° coronal/60° sagittal (53.3 ± 5.3 mm; P < .05 for both). The femoral tunnel created with the AM portal technique at 45° coronal/45° sagittal (40.7 ± 4.8 mm) created a similar tunnel length as the TT technique. For all techniques, the femoral tunnel was significantly shorter in female patients than male patients. Conclusion: The coronal and sagittal obliquity angles of the femoral tunnel in ACL reconstruction can significantly affect its length. The femoral tunnel created with the AM portal technique at 45° coronal/45° sagittal was similar to that created with the TT technique. Clinical Relevance: Surgeons should be aware of the femoral tunnel shortening with lower coronal obliquity angles, especially in female patients.
Infraspinatus Muscle Fiber Moment Arms During Abduction: A Biomechanical Comparison of Values for Intact Rotator Cuff, Supraspinatus Tear, Superior Capsular Reconstruction, and Reverse Total Shoulder Arthroplasty
Authors: Barragan Echenique Diego M. , Dolan Martine T. , Koh Jason L. , Goldberg Benjamin A. , Amirouche Farid 
Published: May 2022

Background: Lines of action of the superior, middle, and inferior infraspinatus muscle fibers work together to produce moment arms that change throughout abduction in an intact shoulder, after a supraspinatus tear, and after superior capsular reconstruction (SCR) and reverse total shoulder arthroplasty (rTSA). Purpose: To use moment arm values to indicate the efficacy of SCR and rTSA to restore infraspinatus function during shoulder abduction. Study Design: Descriptive laboratory study. Methods: A total of 5 human cadaveric shoulders placed in a testing apparatus were each actively abducted (0°-90°) under the following 4 conditions: intact, complete supraspinatus tear, SCR, and rTSA. The 3-dimensional coordinates of points were tracked along the origin and insertion of the superior, middle, and inferior infraspinatus fibers during abduction. Moment arm values were calculated using the origin-insertion method to determine abduction contribution of infraspinatus fiber sections. Analysis of variance and post hoc Tukey testing were used to compare differences in moment arms between the 4 conditions and between fiber sections. Results: In the intact condition, the superior infraspinatus fibers had an abduction moment that decreased with elevation until shifting to adduction. Conversely, the middle and inferior fibers had an adduction moment that turned to abduction (mean moment arm values from 0° to 90°: inferior, from –5.9 to 19.4 mm; middle, from –4.7 to 15.9 mm; superior, from 5.6 to –5.1 mm; P < .05). After a supraspinatus tear, superior fibers lacked any torque, and inferior and middle fibers lost adduction potential (inferior, from 4.8 to 14.0 mm; middle, from –0.2 to 9.6 mm; superior, from 1.0 to 0.7 mm; P < .05). SCR restored the initial superior fiber abduction moment (5.6 mm at 0°; P < .05); middle and inferior fibers had some restoration but were weaker than intact fibers. Loss of abduction moment in all fibers was seen with rTSA (inferior, from –9.6 to –1.6 mm; middle, from –10.5 to –3.6 mm; superior, from –1.7 to –4.6 mm; P < .05). Conclusion: Infraspinatus fiber groups had different and inverse moment arms during scapular plane elevation. SCR most closely resembled the intact shoulder, whereas rTSA transformed the infraspinatus into an adductor. Clinical Relevance: These results support the efficacy of SCR at restoring biomechanical muscle function and suggest that the changes in moment arms for each fiber group be considered when choosing treatment modalities and rehabilitation protocols after rotator cuff tear.
Systematic Review of Operative vs Nonoperative Treatment of Displaced Intraarticular Calcaneal Fractures
Authors: Selim Amr , Ponugoti Nikhil , Chandrashekar Suresh 
Published: May 2022

Background: Management of displaced intraarticular calcaneus fractures can be operative or nonoperative. Several randomized and case-controlled trials have been recently conducted in order to reach a consensus. The purpose of this analysis is to provide recommendations for the management of these injuries based on the best available clinical evidence. Methods: An up-to-date search was conducted using predefined eligibility criteria. The Preferred Reporting Items for Systematic reviews and Meta-analysis (PRISMA) was followed. Randomized and prospective clinical trials were only included after agreement among all authors. Relevant literature was appraised for methodologic quality using the Cochrane collaboration tool for the randomized controlled trials (RCTs) and Newcastle Ottawa Score for the prospective trials. Outcome measures included American Orthopaedic Foot & Ankle Society ankle-hindfoot score, visual analog scale score, return to activity, complications, residual pain, and development of arthritis. RevMan, version 5.3.5 software, was used for data analysis. A P value of <.05 was considered statistically significant, and CIs were set at 95%. Results: A total of 13 studies and 1251 patients were included in our analysis. This involved 10 RCTs and 3 prospective clinical trials. Shoe fitting problems and failure to return to activity favored the operative group. No other studied variables showed clear superiority of a specific treatment approach. Conclusion: The best evidence available at this time favors an advantage to operative treatment. Patients should be informed that the clear differences are centered on comfort of shoe wear and return to desired activity level.Level of Evidence: Level II, meta-analysis of RCT and Prospective Cohort studies.
Mycobacterium tuberculosis-specific CD4 T-cell scoring discriminates tuberculosis infection from disease
Authors: Mantei Andrej , Meyer Tim , Schürmann Mariana , Beßler Christiane , Bias Harald , Krieger David , Bauer Torsten , Bacher Petra , Helmuth Johannes , Volk Hans-Dieter , Schürmann Dirk , Scheffold Alexander , Meisel Christian 
Published: May 2022

BackgroundRapid and reliable diagnostic work-up of tuberculosis (TB) remains a major healthcare goal. In particular, discrimination of TB infection from TB disease with currently available diagnostic tools is challenging and time consuming. This study aimed at establishing a standardised blood-based assay that rapidly and reliably discriminates TB infection from TB disease based on multiparameter analysis of TB antigen-reactive CD4+T-cells acting as sensors for TB stage-specific immune status.Methods157 HIV-negative subjects with suspected TB infection or TB disease were recruited from local tertiary care hospitals in Berlin (Germany). Peripheral blood mononuclear cells were analysed for CD4+T-cells reactive to theMycobacterium tuberculosisantigens purified protein derivative and early secretory antigenic target 6 kDa/culture filtrate protein 10. The activation state of TB antigen-reactive T-cells, identified by surface expression of CD154, was evaluated according to the expression profile of proliferation marker Ki-67 and activation markers CD38 and HLA-DR. Using data from 81 subjects with clinically confirmed TB infection (n=34) or culture-proven pulmonary or extrapulmonary TB disease (n=47), 12 parameters were derived from the expression profile and integrated into a scoring system.ResultsUsing the scoring system, our assay (TB-Flow Assay) allowed reliable discrimination of TB infection from both pulmonary and extrapulmonary TB disease with high sensitivity (90.9%) and specificity (93.3%) as was confirmed by Monte-Carlo cross-validation.ConclusionWith low time requirement, ease of sample collection, and high sensitivity and specificity both for pulmonary and extrapulmonary TB disease, we believe this novel standardised TB-Flow Assay will improve the work-up of patients with suspected TB disease, supporting rapid TB diagnosis and facilitating treatment decisions.
In silico ecotoxicity assessment of photoinduced imidacloprid degradation using HPLC–HRMS, QSAR and ecotoxicity equivalents
Authors: Voigt Melanie , Langerbein Victoria , Jaeger Martin 
Published: May 2022

Abstract
Background
Imidacloprid is among the most widely used insecticides and today is found in surface and ground water worldwide. It has been registered in the EU watchlist for monitoring. To prevent imidacloprid from entering water bodies, advanced oxidation processes (AOP) have been intensely researched. Photo-irradiation proved one of the most efficient methods to degrade and eliminate anthropogenic micropollutants from waters. The ecotoxicity assessment of photoinduced degradation and transformation products especially in the absence of reference standards is still heavily explored.

Results
In this study, UVA and UVC irradiation in combination with titanium dioxide P25 as photocatalyst were investigated for their degrading and eliminating effects and effectiveness on imidacloprid. Humic acid was used as natural organic matter additive. High-performance liquid chromatography coupled with high-resolution mass spectrometry allowed to identify and monitor imidacloprid and its degradation intermediates yielding seven new structures and concentration–time (c–t) profiles. The correlation of structures and the application of radical scavengers and photocatalyst helped distinguish between direct photoinduced and indirect hydroxyl radical-induced degradation mechanisms. The identification of hydroxylated products and intermediates indicated the indirect degradation pathway, which could be suppressed by addition of a radical scavenger. The absence of hydroxylated intermediates and fragments pointed towards the direct absorption-induced degradation. Two degradations products were traced back to the direct mechanism, whereas all other products followed the indirect mechanism. The ecotoxicity of the identified compounds was assessed by quantitative structure–activity relationship (QSAR) analysis. Most products were predicted as less ecotoxic. Ecotoxicity equivalents (ETEs) were introduced allowing a classified ranking of the products and an assessment of the overall hazardous potential of the irradiated solution at a given moment. Generally, the number of hydroxyl substituents was inversely correlated to ecotoxicity. From the c-t curves, time-dependent ETE profiles were established.

Conclusions
Structure elucidation and c-t profiles from liquid chromatography–high-resolution mass spectrometry allowed to distinguish between direct and indirect degradation mechanisms. Structure specific ecotoxicity assessment could be achieved through QSAR analysis. Ecotoxicity hazard was ranked based on ETEs. The time-dependent ETE profile proved suitable to reflect the effect of irradiation duration and allow to estimate the irradiation time required to eliminate ecotoxicity, which may be relevant for potential applications in wastewater treatment plants.
Assessment of a polygenic hazard score for the onset of pre-clinical Alzheimer’s disease
Authors: Vacher Michael , Doré Vincent , Porter Tenielle , Milicic Lidija , Villemagne Victor L. , Bourgeat Pierrick , Burnham Sam C. , Cox Timothy , Masters Colin L. , Rowe Christopher C. , Fripp Jurgen , Doecke James D. , Laws Simon M. 
Published: May 2022

Abstract

Background
With a growing number of loci associated with late-onset (sporadic) Alzheimer’s disease (AD), the polygenic contribution to AD is now well established. The development of polygenic risk score approaches have shown promising results for identifying individuals at higher risk of developing AD, thereby facilitating the development of preventative and therapeutic strategies. A polygenic hazard score (PHS) has been proposed to quantify age-specific genetic risk for AD. In this study, we assessed the predictive power and transferability of this PHS in an independent cohort, to support its clinical utility.

Results
Using genotype and imaging data from 780 individuals enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, we investigated associations between the PHS and several AD-related traits, including 1) cross-sectional Aβ-amyloid (Aβ) deposition, 2) longitudinal brain atrophy, 3) longitudinal cognitive decline, 4) age of onset. Except in the cognitive domain, we obtained results that were consistent with previously published findings. The PHS was associated with increased Aβ burden, faster regional brain atrophy and an earlier age of onset.

Conclusion
Overall, the results support the predictive power of a PHS, however, with only marginal improvement compared to apolipoprotein E alone.
Home blood pressure monitoring and adherence in patients with hypertension on primary prevention treatment: a survey of 1026 patients in general medicine in the Auvergne region
Authors: Trefond Jéromine , Hermet Lucie , Lambert Céline , Vaillant-Roussel Hélène , Pouchain Denis , Ménini Thibault , Pereira Bruno , Vorilhon Philippe 
Published: May 2022

Abstract
Background
Home blood pressure monitoring (HBPM) could improve blood pressure control through therapeutic adherence. The main objective of this study was to determine the link between HBPM used by hypertensive patients treated in primary care and their medication adherence.

Methods
Cross-sectional comparative study conducted in the Auvergne region from June to November 2016. Patients were recruited by general practitioners (GPs) selected at random. Adherence was evaluated according to the Girerd score.

Results
From a sample of eighty-two GPs including 1026 patients, 45% of patients reported owning an HBPM device. Among these, 18% knew the rule of 3 (3 measurements in the morning and 3 in the evening for 3 days) recommended by the French State Health Authority. There was no difference in adherence between patients using HBPM and those who did not. Patients with HBPM using the rule of 3 reported better adherence than patients without the device (p = 0.06), and those who did not perform self-measurements according to the rule of 3 (p = 0.01). Patients who used HBPM according to the rule of 3 were older (p = 0.006) and less smokers (p = 0.001) than the others. Their GPs were more often GP teachers (p < 0.001) who practiced in rural areas (p = 0.001).

Conclusion
The statistical link between medication adherence and HBPM for patients who apply the rule of 3, emphasizes the importance of the GP educating the patient on the proper use of HBPM.
A case of diverticulum of the appendiceal base resembling a submucosal tumor of the cecum under colonoscopy: a hitherto undescribed lesion
Authors: Kimura Toshihisa , Goi Takanori , Kidoguchi Yuki , Ohnishi Kenji , Togawa Tamotsu , Iida Atsushi , Sato Yasunori 
Published: May 2022

Abstract
Background
Diverticulosis of the appendix is an uncommon clinical entity, and a preoperative diagnosis is often difficult. Herein we report an unusual case of appendiceal diverticulosis.

Case presentation
A 72-year-old male was referred to our hospital to examine the cause of hematochezia. A colonoscopy study showed a protruding lesion resembling a submucosal tumor (SMT), approximately 20 mm in diameter, at the site around the appendiceal orifice of the cecum. An abdominal computed tomography and magnetic resonance imaging showed a cystic lesion at the appendiceal base. The lesion was clinically diagnosed as a cystic tumor of the appendix, but the possibility of a malignant tumor could not be excluded. Therefore, a laparoscopic ileocecal resection with lymph node dissection was performed. The pathological examination of the resected specimen revealed that the lesion was a diverticulum (pseudodiverticulum) occurring solitarily at the appendiceal base, in which the mucosal layer of the appendix was invaginated into the submucosa of the adjacent cecum, thus forming an SMT-like lesion.

Conclusion
To our knowledge, this is the first case report in the English literature showing that an appendiceal diverticulum can manifest as an SMT-like lesion in the cecum. This condition should be recognized as a differential diagnosis for such lesions.
Managing abusive experiences: a qualitative study among older adults in Sweden
Authors: Simmons Johanna , Wiklund Nicolina , Ludvigsson Mikael 
Published: May 2022

Abstract
Background
Elder abuse is prevalent, and is associated with poor health outcomes. How an older adult is affected by abusive experiences is dependent on myriad factors, including aspects of the abuse itself, other life circumstances, coping strategies, and what kind of help the older adults receive to manage the experience. In this study, we sought to investigate how older adults themselves describe how they manage abusive experiences. An increased understanding of this could help to tailor society’s response to older adults suffering from abuse.

Method
Participants (n = 30) were recruited from patients admitted to one acute geriatric and one acute internal medicine ward at a university hospital in Sweden. Patients over the age of 65 who reported experiences of elder abuse or who reported that they were still suffering from abuse that had occurred earlier in life were included. In-depth qualitative interviews were conducted, transcribed verbatim, and analyzed using qualitative content analysis.

Results
The analysis resulted in five themes, three pertaining to strategies used to manage abusive experiences (self-reliant coping, restoring dignity in relation to others, and needing formal and informal help) and two pertaining to the disclosure process (inner resistance to disclosure, and external barriers and facilitators for disclosure).

Conclusion
Older adults were found to use a combination of different strategies to manage abusive experiences. Some were self-reliant, but older adults often managed their experiences with the help of others. Health care professionals were generally in a position to facilitate disclosure, but some participants reported poor encounters with health care. The findings indicate a need to facilitate disclosure by, for example, training professionals on issues related to elder abuse and developing more easily navigated response systems that can respond to the complex needs of older adults trying to manage abusive experiences.