bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alpelisib and fulvestrant in PIK3CA-mutated hormone receptor-positive HER2-negative advanced breast cancer included in the French early access program
Authors: ROUFAI Diana BELLO , Goncalves Anthony , Rouge Thibault De La Motte , akla sarra , grenier julien , Gligorov Joseph , Saghatchian Mahasti , bailleux caroline , simon hélène , desmoulins isabelle , tharin zoe , Renaud Emmanuelle , Bertho Marion , Benderra Marc-Antoine , Delaloge Suzette , Robert lucie , Cottu Paul , Pierga Jean-Yves , loirat delphine , Bertucci Anthony , renouf Benjamin , Bidard Francois-Clement , Lerebours Florence 
Published: October 2022

Abstract
Background
SOLAR-1 and BYLIEVE trials documented the efficacy of the PI3K-inhibitor alpelisib in pre-treated PIK3CA-mutant, hormone receptor-positive, HER2-negative (HR+/HER2-) advanced breast cancer (ABC) patients. We report here real-life data of patients prospectively registered in the French alpelisib early access program (EAP).
Patients and methods:
The French EAP was opened to PIK3CA-mutant HR+/HER2- ABC patients treated with alpelisib and fulvestrant, managed per standard of care. Primary endpoint was PFS by local investigators using RECIST1.1.
Results
Eleven centers provided individual data on 233 consecutive patients. Patients had received a median number of 4 (range: 1–16) prior systemic treatments for ABC, including CDK4/6 inhibitor, chemotherapy, fulvestrant and everolimus in 227 (97.4%), 180 (77.3%), 175 (75.1%) and 131 (56.2%) patients, respectively. After a median follow-up of 7.1 months and 168 events, median PFS was 5.3 months (95%CI, 4.7-6.0). Among 186 evaluable patients, CBR at 6 months was 45.3% (95%CI, 37.8–52.8). In multivariable analysis, characteristics significantly associated with a shorter PFS were age < 60 years (HR = 1.5, 95%CI = 1.1–2.1), > 5 lines of prior treatments (HR = 1.4, 95%CI = 1.0–2.0) and the C420R PI3KCA mutation (HR = 4.1, 95%CI = 1.3–13.6). Most frequent grade 3/4 adverse events (AEs) were hyperglycemia, rash, fatigue and diarrhea occurring in 11.6, 9.9, 4.3 and 3% of patients, respectively. N = 91 (39.1%) patients discontinued alpelisib due to AEs.
Discussion
To our knowledge, this is the largest real-life assessment of alpelisib efficacy. Despite heavy pre-treatments, patients derived a clinically relevant benefit from alpelisib and fulvestrant. PFS was not overtly impaired by a prior use of either everolimus or fulvestrant. No new safety signal was found.
FTRTA: Fault Tolerance and Reliable Transmissions Algorithm for IoT
Authors: Vanani Mohsen Mozafari , Dehkordi Pouya Khosravian 
Published: October 2022

Abstract
Features such as severe resource limitations, wireless communication media, network variable topology along with other IoT constraints, have led to increased faults and needs for fault tolerance guarantee in order to network correct performance. Accordingly, many studies have tried to improve this basic field by focusing on different techniques. But past methods are inefficient in stability guarantee and data exchange accuracy with the occurrence of error. In this paper, a method called FTRTA based on the development of RPL protocol and data distribution techniques has been introduced. Distribution techniques are effective in improving the balance of the network traffic load and fault tolerance. FTRTA has designed based on this technique and three operational steps. In the first step, the situation of network nodes is evaluated and analyzed in the same way as in the process of sending DIO messages. In the second step, the network communication graph is formed. Finally in the third step, data transmission is based on distribution technique with the aim of ensuring fault tolerance. The results of simulation using the Cooja software indicate high FTRTA performance in improving factors such as data delivery ratio and network throughput compared to similar studies.
Alfvénic electron acceleration at Jupiter revealed by drifting radio bursts
Authors: Zarka Philippe , Mauduit Emilie , Lamy Laurent 
Published: October 2022

Abstract
The galilean moon Io is known to interact electrodynamically with Jupiter's magnetic field and ionosphere via Alfvén waves [1], producing electromagnetic signatures detectable remotely such as decameter-wave radio emissions generated along the Io Flux Tube (IFT) and UV aurora at the IFT footprints prolongated by a 'tail' emission. These emissions are thought to be produced by electrons having been energized by Alfvénic acceleration [2-4]. Indirect signatures of this acceleration process are the transverse magnetic fluctuations [5-7] and the broadband electron energy spectra [6, 8] observed in situ in the IFT and more generally in Jupiter's auroral regions [9]. A more direct signature is provided by remote measurements of the discrete, fast-drifting, quasi-periodic decameter radio bursts (so-called S-bursts) identified to date only in relation with the Io-Jupiter interaction [10]. S-bursts generation by Alfvén waves has been thoroughly modelled, from electron acceleration to radio emission growth rate [2, 11]. The S-bursts discreteness and quasi-periodicity were correctly reproduced, whereas their time-frequency drift results from the adiabatic motion of accelerated electrons along the IFT. Here, we present the first detection of decameter S-bursts related to the Ganymede-Jupiter interaction and to the main Jovian aurora, revealing the ubiquitous character of Alfvénic electron acceleration in Jupiter's high-latitude regions. We estimate the Alfvén wave periods and the accelerated electrons energy in each case. Two populations of accelerated electrons are found to co-exist, with different energies (a few keV and a few hundred eV).
Relationship of mechanical and electrical dispersion and coronary artery disease in patients on renal replacement therapy
Authors: Stefanovic Milica , Stankovic Ivan , Jemcov Tamara , Gnjidic Nadezda Zec , Maksimovic Aleksandra , Markovic Marko , Milicevic Jovana Kusic , Vidakovic Radosav , Neskovic Aleksandar N. 
Published: October 2022

Abstract
Introduction:

Since coronary artery disease (CAD) is the leading cause of death in patients on renal replacement therapy (RRT), detection of asymptomatic CAD before the impairment of left ventricular (LV) systolic function is of great clinical importance.

Aim

To investigate the relationship between electrical and mechanical dispersion and CAD in angina free RRT patients with preserved LV ejection fraction (LVEF).

Material and methods

A total of 78 patients (mean age 59 ± 13 years, 54% male), with LVEF ≥ 50% were included in this prospective study. Electrical dispersion was defined as the difference between the longest and shortest corrected QT interval. The duration of mechanical contraction was determined by myocardial strain analysis. Mechanical dispersion was defined as the standard deviation of mechanical contraction durations of all LV segments (MD_SD) or the difference between the longest and shortest duration of mechanical contraction (MD_delta). A coronary calcium score using cardiac computed tomography was assessed in a subgroup of 20 patients without known CAD.

Results

Documented CAD was present in 14% of study patients. There was no significant correlation between electrical and mechanical dispersion (p > 0.05). In contrast to electrical dispersion, mechanical dispersion was independently associated with CAD (odds ratio 1.05, 95% confidence interval 1.01–1.09, p = 0.010). In patients without documented CAD, MD_delta was strongly correlated with total coronary calcium score (r = 0.57; p = 0.01), while QTc dispersion was not.

Conclusion

Electrical and mechanical dispersion are not correlated in dialysis patients. Unlike electrical dispersion, mechanical dispersion is associated with both documented CAD and silent coronary atherosclerosis in patients with end stage renal failure on RRT.
Comparison of systemic morphine, nalbuphine, and epidural analgesia on acute and chronic postoperative pain in laparoscopic colorectal surgery: A randomized controlled trial
Authors: Jiang Yan , Liang Xiao-Long , Sun Shu-Fang , Liu Hong-Liang 
Published: October 2022

Abstract
Purpose
Postoperative pain and complications are still common after colorectal surgery, and pain can put patients in a stressful condition and precipitate complications. Thus, sufficient postoperative analgesia is essential for patient recovery. This study aimed to compare the efficacy of various postoperative analgesic strategies in laparoscopic colorectal surgery.
Patients and methods:
One hundred patients undergoing laparoscopic colorectal cancer surgery were recruited, and 69 patients were eventually included and randomly divided into three groups: patient-controlled epidural analgesia (PCEA) with ropivacaine (Group R, n = 23), patient-controlled intravenous analgesia (PCIA) with morphine (Group M, n = 23) or nalbuphine (Group N, n = 23). Pain at rest (PAR), movement-evoked pain (MEP), stress hormone and complications during the 72 hours after surgery, and chronic postsurgical pain (CPSP) at 3 months and 6 months were recorded.
Results
There was no significant difference in PAR among the 3 groups, whereas patients in Group N had a higher intensity of MEP than those in Group R during the 72 hours after surgery (P < 0.05). There was no significant difference in CPSP at 6 months among the 3 groups (P > 0.05), but the incidence of CPSP at 3 months was higher in Group N (P = 0.01, vs Group R), and CPSP at 3 months was closely correlated with MEP (P < 0.05). There were no significant differences in cortisol and adrenocorticotropic hormone levels among the 3 groups (P > 0.05). The incidences of pruritus and postoperative nausea and vomiting (PONV) were found to be significantly higher in Group M than in the other two groups (P < 0.05). The time to the first flatus after surgery was shorter in Group R than in Group M or Group N (P < 0.05).
Conclusion
PCEA is the first choice for postoperative analgesia in laparoscopic colorectal surgery. Regarding the similar analgesic effect between morphine and nalbuphine, and the higher side effects from morphine, PCIA with nalbuphine might be a better choice in patients who have contraindications for PCEA or with a history of or a high risk for PONV or pruritus.
Trial registration:
This study was registered at http://www.chictr.org.cn/usercenter.aspx (registration No: ChiCTR-INR-17011092) on April 8, 2017.
Biofeedback Towards Machine Learning Driven Self-guided Virtual Reality Exposure Therapy Based on Arousal State Detection from Multimodal Data
Authors: Rahman M Arifur , Brown David J , Mahmud Mufti , Shopland Nicholas , Haym Nadja , Sumich Alexander , Turabee Zakia Batool , Standen Brad , Downes David , Xing Yangang , Thomas Carolyn , Haddick Sean , Premkumar Preethi , Nastase Simona , Lewis James , Harris Matthew 
Published: October 2022

Abstract
Virtual-reality exposure therapy (VRET) is a novel intervention technique that allows individuals to experience anxiety-evoking stimuli in a safe environment, recognise specific triggers and gradually increase their exposure to perceived threats. Public-speaking anxiety (PSA) is a prevalent form of social anxiety, characterised by stressful arousal and anxiety generated when presenting to an audience. In self-guided VRET, participants can gradually increase their tolerance to exposure and reduce anxiety-induced arousal and PSA over time. However, creating such a VR environment and determining physiological indices of anxiety-induced arousal or distress is an open challenge. Environment modelling, character creation and animation, psychological state determination and the use of machine learning models for anxiety or stress detection are equally important, and multi-disciplinary expertise is required.In this work, we have explored a series of machine learning models with publicly available data sets (using electroencephalogram and heart rate variability) to predict arousal states. If we can detect anxiety-induced arousal, we can trigger calming activities to allow individuals to cope with and overcome distress. Here, we discuss the means of effective selection of machine learning models and parameters in arousal detection. We propose a pipeline to overcome the model selection problem with different parameter settings in the context of Virtual Reality Exposure Therapy. This pipeline can be extended to other domains of interest where arousal detection is crucial. Finally, we have implemented a biofeedback framework for VRET where we successfully provided feedback as a form of heart rate and brain laterality index from our acquired multimodal data for psychological intervention to overcome anxiety.
Fibrinogen Is an Independent Preoperative Predictor of Hospital Length of Stay Among Patients Undergoing Coronary Artery Bypass Grafting
Authors: Huang Chunsheng , Zhang WenYuan , Chen Xiaofei , Xu Xia , Qiu Jun , Pan Zhihao 
Published: October 2022

Abstract
Objective：This study aims to examine the impact of preoperative fibrinogen concentration on the short-term outcomes and length of postoperative hospital stay (LOPS) of patients undergoing Coronary Artery Bypass Grafting (CABG).
Methods：Between January 2010 and June 2022, a retrospective analysis comprised 936 patients who sequentially received isolated, primary off-pump or on-pump CABG. The preoperative fibrinogen concentration, baseline index, intraoperative data, ICU stay duration, and LOPS were documented. The prime endpoint was LOPS. Evaluation of the link between preoperative fibrinogen concentration and LOPS was accomplished through the use of univariate as well as multiple linear regression.
Results: Preoperative low fibrinogen concentration (B= -0.072, P= 0.03), male gender (B = 0.066, P =0.04), and elevated K concentration (B = -0.078, P =0.01) were associated with prolonged LOPS. preoperative fibrinogen concentration (B= -0.073, P= 0.03) and plateletcrit (PCT) (B= -0.121, P＜ 0.01) were also related with the volume of postoperative bleeding.
Conclusions: Fibrinogen is an independent preoperative predictor of both the LOPS and the volume of bleeding that occurs after CABG. Patients whose preoperative fibrinogen concentration was low experienced a greater loss of blood and a longer LOPS. A greater preoperative K concentration and male gender were associated with a longer LOPS.
SGK1 affects bovine adipocyte proliferation and differentiation via regulation of the PI3K/Akt signaling pathway
Authors: Lei Zhaoxiong , Pan Cuili , Wei Dawei , Cai Bei , Tang Lin , Wang Shuzhe , Ma Yanfen , Ma Yun 
Published: October 2022

Abstract
Objectives: Serum/glucocorticoid-inducible kinase 1 (SGK1) gene encodes a serine/threonine protein kinase that plays an essential role in cellular stress response and regulation of multiple metabolic processes. However, its role in bovine adipogenesis remains unknown. In this study, we aimed to clarify the role of SGK1 on bovine preadipocyte differentiation.
Materials and Methods: Preadipocytes were induced to differentiation to detect the temporal expression pattern of SGK1. Heart, liver, lung, spleen, kidney, muscle and fat tissues were collected to detect its tissue expression profile. Recombinant adenovirus and the lentivirus were packaged for overexpression and knockdown. Oil Red O staining, quantitative real-time PCR, Western blot analysis, Yeast two-hybrid assay, and RNA-seq were performed to study the regulatory mechanism of SGK1.
Results: SGK1 showed significantly higher expression in adipose and revealed significantly induced expression in differentiated adipocytes. Furthermore, overexpression of SGK1 greatly promoted adipogenesis and inhibited proliferation, which could be shown by the remarkable increasement of lipid droplet, and the expression levels of adipogenic marker genes and cell cycle-related genes. Inversely, its knockdown inhibited adipogenesis and facilitated proliferation. Mechanistically, SGK1 regulates the phosphorylation and expression of two critical genes located in the downstream of PI3K/Akt signaling pathway, FOXO1/FOXO3, thus promoting adipogenesis and inhibiting proliferation in cattle.
Conclusions: SGK1 is required for bovinepreadipocyte proliferation and differentiation, which contributes to a better understanding of fat deposition in cattle.
The risk of irritable bowel syndrome in patients with metabolic syndrome：a population-based, 5-year follow-up cohort study
Authors: Wang Zhiyuan , Feng Yan , Shi Tian , Gao Feng 
Published: October 2022

Abstract
Purpose
Few studies have reported the associations between metabolic syndrome (MetS) and irritable bowel syndrome (IBS). The purpose of this study was to investigate the incidence of IBS in patients with MetS during a 5-year follow-up period and to evaluate potential risk of IBS.
Methods
A retrospective cohort study was conducted, and 5104 subjects who underwent physical examination in the People's Hospital of Xinjiang Uygur Autonomous Region in October 2014 were randomly selected and divided into MetS group, pre-metabolic syndrome (Pre-MetS) group and healthy control (HC) group. The clinical datas and the incidence of IBS were recorded and analyzed.
Results
In total, 663 subjects were diagnosed with IBS. The 5-year cumulative incidence rate of IBS was 20.7% and 16.6% for MetS and Pre-MetS group, respectively, which was significantly higher than that of HC group (7.1%, log-rank < .001). In the univariate analysis, the indicators associated with IBS were larger waist circumference, hypertriglyceridemia, animal food-predominant form, anxiety and depression. After stepwise adjustment for multiple factors, the hazard ratio of IBS were 2.665 (95%CI 1.992–3.565) and 3.372 (95%CI 2.177–5.223) for MetS and Pre-MetS group, respectively. In the MetS components, there may be predictive value for the development of IBS when waist circumference is 86.5 cm and triglyceride (TG) is 307.5 mg/dL.
Conclusions
The risk of IBS was significantly increased in both MetS and Pre-MetS patients during 5-year follow-up, suggesting that MetS status, especially larger waist circumference and higher TG, may be potential risk factors for IBS.
Study of Environmental and Familial Risk Factors for Autism Spectrum Disorder in Syria
Authors: Al-Manasfi Anas , Al-Hariri Nour Al-Din , Latifa yousif 
Published: October 2022

Abstract
Background:
Autism spectrum disorder (ASD) is a complex developmental condition involving persistent challenges with social communication, restricted interests, and repetitive behavior. While autism is considered a lifelong disorder, the degree of impairment in functioning because of these challenges varies between individuals with autism. (1)
Design:
A Cross-Sectional Study conducted in Syria.
Methods:
The study sample included 374 children diagnosed with autism spectrum disorder, collected from centers in Syria, they were divided into two groups, the first group is the patient group (271) children, representing 72.5% of the study sample, while the second group is the control group (103) patients, or 27.5% of the study sample.
Results:
After studying environmental and family risk factors for autism spectrum disorder on a sample of 374 children, 271 with autism, 103 without, the results were the following: There is a statistically significant relationship between the incidence of autism spectrum disorder, and the gender of the child, the season of the child's birth, Consanguinity between the parents, the child's arrangement in the family, the gestational age at birth, the occurrence of problems at birth, and the father's smoking.
FoxO3 Regulates the Progress and Development of Aging and
Aging-Related Diseases
Authors: Chang Zao-Shang , He Zhi-Ming , Xia Jing-Bo 
Published: October 2022

Abstract:
Aging is an inevitable risk factor for many diseases, including cardiovascular
diseases, neurodegenerative diseases, cancer, and diabetes. Investigation into the
molecular mechanisms involved in aging and longevity will benefit the treatment of
age-dependent diseases and the development of preventative medicine for agingrelated
diseases. Current evidence has revealed that FoxO3, encoding the transcription
factor (FoxO)3, a key transcription factor that integrates different stimuli in the
intrinsic and extrinsic pathways and is involved in cell differentiation, protein homeostasis,
stress resistance and stem cell status, plays a regulatory role in longevity and in
age-related diseases. However, the precise mechanisms by which the FoxO3 transcription
factor modulates aging and promotes longevity have been unclear until now.
Here, we provide a brief overview of the mechanisms by which FoxO3 mediates signaling
in pathways involved in aging and aging-related diseases, as well as the current
knowledge on the role of the FoxO3 transcription factor in the human lifespan and its
clinical prospects. Ultimately, we conclude that FoxO3 signaling pathways, including
upstream and downstream molecules, may be underlying therapeutic targets in aging
and age-related diseases.
Pharmacological and Physiological Correlates of the Bidirectional Fear
Phenotype of the Carioca Rats and Other Bidirectionally Selected Lines
Authors: Lages Yury V. , Balthazar Laura , Krahe Thomas. E. , Landeira-Fernandez J. 
Published: October 2022

Abstract:
The Carioca rat lines originated from the selective bidirectional breeding of mates displaying
extreme defense responses to contextual conditioned fear. After three generations, two distinct
populations could be distinguished: the Carioca High- and Low-conditioned Freezing rats, CHF, and
CLF, respectively. Later studies identified strong anxiety-like behaviors in the CHF line, while indications
of impulsivity and hyperactivity were prominent in the CLF animals. The present review details
the physiological and pharmacological-related findings obtained from these lines. The results discussed
here point towards a dysfunctional fear circuitry in CHF rats, including alterations in key brain
structures and the serotoninergic system. Moreover, data from these animals highlight important alterations
in the stress-processing machinery and its associated systems, such as energy metabolism and
antioxidative defense. Finally, evidence of an alteration in the dopaminergic pathway in CLF rats is
also debated. Thus, accumulating data gathered over the years, place the Carioca lines as significant
animal models for the study of psychiatric disorders, especially fear-related ones like anxiety.
Modelo de función de transferencia para pronosticar el precio del huevo blanco, 2000 – 2017
Authors: Luis-Rojas Samuel , García-Sánchez Roberto Carlos , García-Mata Roberto , Arana- Coronado Oscar Antonio , González-Estrada Adrián 
Published: October 2022

El huevo es una de las fuentes de proteína más accesible y con disponibilidad amplia en el mercado. El objetivo de este trabajo fue desarrollar un modelo de series de tiempo para pronosticar los precios nominales mensuales de huevo blanco pagados al productor en México (PPHBP) mediante modelos de función de transferencia (MFT) y evaluar su relación con los precios promedios rurales del sorgo (PPSRG). Los parámetros y las predicciones se estimaron con el método de máxima verosimilitud y fueron estadísticamente apropiadas y significativas. El mejor MFT que representó el comportamiento de los PPHBP fue el de dos coeficientes autorregresivos, tres de media móvil, dos grados de denominador â€œrâ€, un grado de numerador â€œsâ€ y un coeficiente â€œbâ€. Se encontró que el PPSRG impacta un mes después en los PPHBP, disminuyendo la varianza original del PPHBP de 0.01036 a 0.009771 con el modelo de transferencia. El MFT genera mejores pronósticos de los PPHBP que el modelo SARIMA, debido a que el primero, toma en cuenta la evolución temporal del PPSRG logrando estimaciones más cercanas a la realidad, útiles para planificar y tomar decisiones en el sector avícola a corto y mediano plazo.