bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of micro‐nano bubble aerated irrigation and levels of nitrogen fertilizer on nitrogen accumulation and metabolism in super rice
Authors: Xiao Wei‐hua , Liao Qiong , Fu Jian‐jun , Liu Yan‐ni , Zhang Cui‐ping , Zhang Wen‐ping 
Published: November 2022

AbstractMicro‐nano bubble aerated irrigation (MNBI) is an innovative technology that generates nano‐diameter bubbles in irrigation water via a micro‐nano bubble device. In this study, pot experiments with three different nitrogen level treatments under conventional irrigation and MNBI were conducted to investigate the effects of MNBI and nitrogen application levels on rice yield, nitrogen accumulation and utilization. The results showed that MNBI promoted rice yields by increasing the seed setting rate compared to conventional irrigation, and nitrogen accumulation was positively correlated with nitrogen application but significantly increased by MNBI due to the increased root growth and activity. Furthermore, the activity of key enzymes involved in nitrogen metabolism, nitrate reductase and glutamine synthetase, significantly increased under MNBI at a nitrogen level of 225 kg ha−1. In conclusion, with the elevation of nitrogen application, MNBI improved rice yields and nitrogen accumulation and utilization, indicating that nitrogen and MNBI synergistically enhanced rice yields. Thus, the results provide the basis for efficient and high‐yielding super rice cultivation.
Similarly low blood metal ion levels at 10‐years follow‐up of total hip arthroplasties with Oxinium, CoCrMo, and stainless steel femoral heads. Data from a randomized clinical trial
Authors: Høl Paul Johan , Hallan Geir , Furnes Ove , Fenstad Anne Marie , Indrekvam Kari , Kadar Thomas 
Published: November 2022

AbstractThe use of inert head materials such as ceramic heads has been proposed as a method of reducing wear and corrosion products from the articulating surfaces in total hip arthroplasty, as well as from the stem‐head taper connection. The aim of the present study was to compare the blood metal ion levels in patients with Oxinium and CoCrMo modular femoral heads, as well as monoblock stainless steel Charnley prostheses at 10 years postoperatively. The 150 patients with osteoarthritis of the hip joint included in a randomized clinical trial were grouped according to femoral head material. One group (n = 30) had received the Charnley monoblock stainless steel stem (DePuy, UK). The other patients (n = 120) received a Spectron EF CoCrMo stem with either a 28 mm CoCrMo or Oxinium modular head (Smith & Nephew, USA). After 10 years, 38 patients had withdrawn, 19 deceased, 7 revised due to aseptic loosening and 5 revised due to infection. The 81 patients with median age of 79 years (70–91) were available for whole blood metal ion analysis. The levels of Co, Cr, Ni and Zr in the blood were generally low with all the head materials (medians <0.3 micrograms/L) and no statistical difference between the groups were found (p = .2–.8). Based on the low blood metal ion values in our study groups, no indication of severe trunnion corrosion in patients with CoCrMo heads was observed, neither was there any beneficial reduction in metal ion exposure with the Oxinium femoral heads.
Which is the best time to perform balloon valvuloplasty in critically fetal aortic stenosis: Prenatally or after birth?
Authors: Rizzo Giuseppe , Pietrolucci Maria Elena , Mappa Ilenia 
Published: November 2022

AbstractFetal aortic valvuloplasty may prevent the progression of severe fetal aortic stenosis to hypoplastic left heart syndrome at birth. Since it is an high risk procedure a careful selection of fetuses that can benefit from the prenatal treatment instead of waiting for postnatal intervention.
Pyrolysis‐induced phosphorus transformations for biosolids from diverse sources
Authors: Freitas Andressa Morato , Nair Vimala D. , Harris Willie G. , Mosquera‐Losada Maria Rosa , Ferreiro‐Domínguez Nuria 
Published: November 2022

AbstractBiosolids have been long used as a soil amendment to promote nutrient recovery. The readily releasable forms of nutrients present in this biowaste, such as phosphorus (P), along with their over application, can be detrimental to the environment, causing eutrophication. Pyrolysis, the thermal decomposition of organic materials at elevated temperature and low oxygen, seems to be a promising strategy to lower P release from biowastes such as biosolids. We pyrolyzed biosolids from various treatments and locations (Florida and Illinois; Galicia, Spain; and São Paulo, Brazil) to convert to biochar. Our objectives were (a) to use solid‐state assessments, such as X‐ray diffraction and scanning electron microscopy, and chemical assessments, such as water‐soluble P (WSP), pH, Mehlich 3‐extractable P (M3‐P), total P (TP), and total Kjeldahl nitrogen, to evaluate changes caused by the conversion and (b) to compare P leaching potentials of biosolids and their corresponding biochars on two soils with varying P retention capacities. Pairwise comparisons indicated that biochar conversion significantly increased TP in the final material, but the absolute WSP decreased. However, M3‐P remained the same after conversion to biochar. Cumulative P leached as a fraction of TP was greater for biosolids than their corresponding biochars. Two soils with contrasting P retention capacities predictably differed in P leaching behaviors as amended with biosolids and biochars. Differences suggest that future research could evaluate the efficacy of using mixtures of biosolids and biochar for a given soil to maintain soil fertility while reducing environmental P loss risk.
MiR‐33‐5p alleviates spinal cord injury in rats and protects PC12 cells from lipopolysaccharide‐induced apoptosis
Authors: Li Zhe , Rong Yan‐Long , Zhang Yuan‐Shi 
Published: November 2022

AbstractMicroRNAs (miRNAs) exert critical effects in spinal cord injury (SCI). The miR‐33‐5p level is found to be lower in rats with SCI compared with that in control (untreated) and sham‐operated (laminectomy but no contusion) rats. Therefore, we investigated the biological functions of miR‐33‐5p and related mechanisms in SCI pathogenesis and development. An in vivo SCI model and a lipopolysaccharide (LPS)‐induced cell model of SCI were established. A downregulated level of miR‐33‐5p in experimental SCI and in LPS‐treated PC12 cells was revealed by reverse transcriptase‐quantitative polymerase chain reaction (RT‐qPCR). MiR‐33‐5p upregulation alleviated the leakage of the blood–spinal cord barrier (BSCB) induced by SCI and improved the neurological functions of SCI rats, as evidenced by the Basso, Beattie, and Bresnahan (BBB) scores and Evans blue staining. The regulatory relationship between miR‐33‐5p and Rps6kb1 was verified by luciferase reporter assays, which demonstrated that miR‐33‐5p bound to the Rps6kb1 3′UTR. Moreover, as MTT assays and flow cytometry showed, the suppressive effects of miR‐33‐5p upregulation on cell apoptosis were attenuated by Rps6kb1 upregulation. In conclusion, miR‐33‐5p ameliorates SCI in rats and inhibits the LPS‐induced apoptosis of PC12 cells.
The role of the multidisciplinary team in the management of psoriatic arthritis
Authors: Jadon Deepak R. , Helliwell Philip S. 
Published: November 2022

AbstractPsoriatic arthritis (PsA) has a heterogenous clinical phenotype with manifestations in a number of different organs and systems. Whilst PsA is typified by enthesitis, synovitis and psoriasis (skin and nail); innate and adaptive immune system dysfunction often results in concomitant conditions. These include inflammatory bowel disease, uveitis, metabolic syndrome, metabolic bone disease and mental health issues. All of which have the potential to impact on quality of life, daily function, employment, family life and social activities. Through a collection of clinical vignettes, we describe the importance of multi‐disciplinary and multi‐speciality involvement in the care of people with PsA.
Carbon Nanotubes‐Based Nanofluidic Devices: Fabrication, Property and Application
Authors: Zhou Haoyang , Li Weiqi , Yu Ping 
Published: November 2022

AbstractWith the rapid development of nanofluidics, more and more unexpected behaviors and bizarre properties have been discovered, which brings more possibility to solve the water and energy problem. Carbon nanotubes (CNTs) with nanoscale diameter and ultrasmooth hydrophobic surface provide strong confinement and unusual water‐carbon couple which lead to many exotic properties, such as flow enhancement, strong ion exclusion, ultrafast proton transport and phase transition. This article reviews the recent progresses of CNT‐based nanofluidic devices in fabrication, property, and applications. Moreover, challenges and opportunities of the CNT‐based nanofluidic devices are discussed.
Preparation of Three‐Dimensional Porous Graphene by Hydrothermal and Chemical Reduction with Ascorbic Acid and its Electrochemical Properties
Authors: Liu Hui , Sun Baiqing , Zhu Peiyuan , Liu Chenyu , Zhang Gaimei , Wang Dongdong , Song Xiaoli , Shi Jiazi , Yang Yonggang , Lu Jiandong 
Published: November 2022

AbstractThree‐dimensional porous graphene (3D‐PG) has attracted much attention due to its excellent electrochemical performance. Chemical reduction is one of common methods for preparing porous graphene. In order to develop a green and facile method for preparing three‐dimensional porous graphene, in this paper, 3D‐PG was fabricated by reduction of graphene oxide (GO) with ascorbic acid (AA) as reductant in hydrothermal condition based on non‐toxic, non‐flammable and mild reducing performance of ascorbic acid. It was found that the size and distribution of pores could be controlled by the reduction time and the concentration of AA in the solution. The pore sizes in R0, R1 and R2 were in the range of 0.5–1 μm, 1–1.5 μm, and 1.5–3 μm, respectively. It was found that the average pore size and volume increased along with the amount of reductants. Under optimal conditions – a reaction time of 20 h and a ratio of GO to AA=1 : 1 – the CV area of the so‐obtained sample R1‐20 at 100 mV was 0.06 and the specific capacitance of the 3D‐PG electrode reaches 153.5 F ⋅ g−1, which is suitable for use in supercapacitors.
Screening and Identification of Natural Product‐Like Compounds as Potential Antibacterial Agents Targeting FemC of Staphylococcus aureus: An in‐Silico Approach
Authors: Dalal Vikram , Kumari Reena 
Published: November 2022

AbstractFemC is a methicillin resistance factor and regulates the synthesis of peptidoglycan in Staphylococcus aureus. Here, a set of natural product‐like compounds from Enamine and Selleckchem databases were screened at the active site of validated FemC model. Molecules that had interactions and good binding energies with protein were filtered by pharmacokinetic and ADMET properties. Molecular docking and molecular dynamics (MD) analysis displayed the identified molecules had stable and static interactions with FemC to form stable FemC‐inhibitor(s) complexes. Molecular Mechanics/Poisson‐Boltzmann Surface Area (MMPBSA) confirmed that identified molecules interacted with S15, M16, S17, R31, R43, Q47, K48, and R49 of FemC and resulted in the formation of lower energy complexes. The current study, hereby, reported the four (S4958 Glycocholic acid, SP‐146, Hupehenine, and Limonin) potent natural product‐like compounds that are required to be validated and may be further utilized to develop novel scaffolds for antimicrobials against S. aureus.
Photocatalytic Production of Oxygen by Nitrogen Doped Graphene Oxide Nanospheres: Synthesized via Bottom‐Up Approach Using Dibenzopyrrole
Authors: Verma Amit Kumar , Tripathi Prerna , Alam Zahoor , Mishra Shiva Kant , Ray Biswajit , Sinha A. S. K. , Singh Shikha 
Published: November 2022

AbstractIn this article, we present the formation of nitrogen (N) doped graphene oxide nanospheres (N‐GONs) and investigate their applicability for photocatalytic water splitting. We chose a simple “bottom‐up” method for synthesizing N‐GONs. Dibenzopyrrole as a basic structural unit was used for constructing N‐GONs. Nitration is an intermediate step, subsequent hydrothermal treatment of nitro derivatives imparted oxygen functionalities, which was well proved via CHNS and XPS analysis. ∼14 % and 39 % of nitrogen and oxygen were present inside N‐GONs. The average size of N‐GONs is in‐between 30–80 nm. N‐GONs typically have a band gap of nearly 2.61 eV. The valance and the conduction bands alignments of N‐GONs w.r.t to standard hydrogen electrode were evaluated through UPS and XPS studies. The alignments were found to be well suited for H2O splitting applications. N‐GONs have n‐type semiconductor features and a charge carrier density of 1.12×1022 cm−3. While studying photocatalytic dissociation of water we identified oxygen as the only product. Significantly, 1 g of N‐GONs produced ∼1.3 mmol of oxygen over the course of 1 h. These backgrounds clearly suggest the possibilities of ongoing oxygen reduction and oxygen evolution reactions simultaneously. No‐significant traces of H2O2 were observed which suggested immediate H2O2 disproportionation to O2 and H2O on N‐GONs. The proposed photocatalytic activity of N‐GONs is also confirmed by RRDE method for ORR catalysis.
Design, Synthesis, and In Vitro Mitotic Evaluation of 3‐Amino‐Isoquinolinones as Anticancer Agents
Authors: Abrams Jason N. 
Published: November 2022

AbstractIn this study, a series of N‐(3‐amino‐1‐oxo‐2(1H)‐isoquinolinyl)benzamides and butyramides were designed and synthesized, and several of them showed mitotic therapeutic activity against renal and breast tumors. The most effective compounds were N‐(3‐amino‐1‐oxo‐2(1H)‐isoquinolinyl)benzamides bearing an electron‐withdrawing group on their benzamide moieties. N,N‐Carbonyldiimidazole promotes cross‐coupling between 2‐(cyanomethyl)benzoic acids and commercial acyl hydrazides, followed by intramolecular cyclization to afford these compounds via a two‐stage protocol. This process is enhanced through addition of imidazole ⋅ HCl which serves as a catalyst for the production of the acyl imidazole/imidazolium intermediate through the first stage. Gentle overnight heating at 60 °C after the addition of the acyl hydrazide during the second stage affords a final product that either precipitates from the solution or forms as a pure compound upon addition of a small amount of water.
Dihydrotanshinone I: A Target for STAT3 in the Therapy of Tamoxifen‐Resistant Breast Cancer
Authors: Wo Guanqun , Zhu Zhen , Fang Zheng , Chen Xi , Liang Mingxing , Wang Yalin , Shao Xinyi , Shen Hongyu , Tang Jin‐Hai 
Published: November 2022

AbstractBreast cancer is the most prevalent tumour in women. Over two‐thirds of breast cancers are estrogen receptor (ER)‐positive breast cancers. These breast cancer patients are prone to tamoxifen resistance during breast cancer treatment. There is still a lack of effective clinical treatment for tamoxifen‐resistant breast cancer. Dihydrotanshinone I (DHTS) promotes various types of apoptosis in tumour cells. Our network pharmacology study revealed that DHTS has a strong binding capacity to STAT3. Tamoxifen‐resistant breast cancers are often accompanied by STAT3 activation. However, there are no reports of DHTS for tamoxifen‐resistant breast cancer. Subsequent in vitro experiments also confirmed that DHTS promoted apoptosis in MCF‐7‐TamR cells, down‐regulated the performance of STAT3, pSTAT3, and BCL‐2, and activated the production of apoptosis‐associated PARP1 and cleaved caspase3. This process could be rescued by overexpression of BCL‐2 downstream of STAT3 and was not rescued by either the cytokine EGF or the cytokine PDGF, which promote STAT3 phosphorylation. We hypothesized that DHTS targeting STAT3 promotes apoptosis in MCF‐7‐TamR cells, mainly by affecting STAT3 phosphorylation. Our research approach described above may provide new ideas for the treatment of tamoxifen‐resistant breast cancer.
Induced Crystallization‐Controllable Nanoarchitectonics of 3D‐Ordered Hierarchical Macroporous Co@N‐Doped Carbon Frameworks for Enhanced Microwave Absorption
Authors: He Peng , Ma Wenjun , Xu Jian , Wei Jie , Liu Xiaoyun , Zuo Peiyuan , Cui Zhong‐Kai , Zhuang Qixin 
Published: November 2022

AbstractThe construction of ordered hierarchical porous structures in metal–organic frameworks (MOFs) and their derivatives is highly promising to meet the low‐density and high‐performance demands of microwave absorption materials. However, traditional methods based on sacrificial templates or corrosive agents inevitably suffer from the collapse of the microporous framework and the accumulation of nanoparticles during the carbonization transformation, resulting in the deteriorating impedance match, which greatly limits the incident and attenuation of microwaves. Herein, an induced crystallization and controllable nanoarchitectonics strategy is employed to replace traditional growing‐etching methods and successfully synthesize carbonized 3D‐ordered macroporous Co@N‐doped carbon (3DOM Co@NDC) based on the 3D‐ordered template. The obtained 3D‐ordered macroporous structure ensures the stable growth of hybrid carbon frameworks and CoC nanoparticles without collapse, preserves abundant interfaces for both the incident and attenuation performance, so as to significantly improve the impedance matching and absorption properties compared to conventional MOFs derivatives. The minimum reflection loss of 3DOM Co@NDC is −57.36 dB at the thickness of 1.9 mm, and the effective bandwidth is 7.36 GHz at 1.6 mm. Moreover, the innovative strategy to prepare 3D‐ordered hierarchical macroporous structures opens up a new avenue for advanced MOFs‐derived absorbers with excellent performance.
Effect in Physical, Thermo‐Mechanical Properties, and In Vitro Starch Digestibility of Extruded and Microwave‐Expanded Snacks—Mixture of Blue Corn, Black Bean, and Chard: An Optimization Study
Authors: Neder‐Suárez David , Lardizábal‐Gutiérrez Daniel , Meléndez‐Pizarro Carmen Oralia , Tabio‐García Danger , Zazueta‐Morales José de Jesús , Rodríguez‐Roque María Janeth , Hernández‐Ochoa León Raúl , Delgado‐Nieblas Carlos Iván , Quintero‐Ramos Armando 
Published: November 2022

AbstractA mixture of blue corn, black bean, and chard with a moisture content (MC) of 22.3–35.7% is extruded at different extrusion temperatures (ET) (102—142 °C) using screw speeds (SP) of 96–172 rpm, and the extruded mixtures are subsequently expanded using microwave radiation to produce third‐generation (3G) snacks. The degree of starch gelatinization (DG); in vitro starch digestibility (SD); specific mechanical energy (SME); physical properties: radial expansion (RE), flexural modulus (Ef), and bulk density (BD); and rheological properties: storage modulus (G′) and loss modulus (G″) are evaluated and optimized. In addition, X‐ray and microstructure analyses are studied to correlate the chemical and structural changes. The SP and MC affect most variables in the unexpanded snack (UETS) and microwave‐expanded snacks (MWES). Increased MC results in UETS with low SD, DG, rheological properties, and mechanical resistance. An increase in SP at low MC results in MWES with high RE, low BD, and Ef while an increase in MC lowers SD. Micrographs and X‐ray diffraction spectra reveals that the extrusion results in a V‐type starch crystalline structure. The optimal conditions (24% MC, 133 rpm, and 122 °C) result in good expansion and moderate SD, DG, and SME products.
Cover Image
Authors: Yang Dingding , Zhao Yan , Nie Binbin , An Leiting , Wan Xiangdong , Wang Yazhou , Wang Wenting , Cai Guohong , Wu Shengxi 
Published: November 2022

The cover image is based on the Advanced Review Progress in magnetic resonance imaging of autism model mice brain by Dingding Yang et al., https://doi.org/10.1002/wcs.1616.
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Introduction: In the Pursuit of Human Flourishing
Authors: Las Heras Mireia , Grau-Grau Marc , Rofcanin Yasin 
Published: November 2022

AbstractThe study of the good life or Eudaimoniahas been a central concern for academics and philosophers, as well as for many people, at least since Aristotelian times. This responds to the common experience that we all seek happiness. Today, we are witnessing a new paradoxical boom. The pursuit of happiness seems to permeate everything (i.e., books, media, organizations, talks), without reducing, or in some cases even increasing, the numbers of suicides, depression, and similar pathological consequences of anxiety and stress.
Travel Literature as an Example of Human Flourishing
Authors: Pérez-Martínez Ángel 
Published: November 2022

AbstractTravel Literature can be a way of approaching eudaimonia and an interdisciplinary meeting point. When travelling, the individual is exposed to a multiple encounter experience. On the other hand, travelling is an intergenerational experience, and it will be increasingly so. From this perspective, it is possible to enrich studies by focusing on tourism and globalization, but also on relationships with technology. It is also possible, from this angle, to open new ways of developing new narratives that deepen in the encounter with oneself, with other cultures and that define new values in an ethics of human flourishing. The attempt to synthetize Travel Literature, an “elusive genre”, does not only contribute to sort out a tenuous typology, but also evidences the need to keep thinking about two fundamental dimensions of human existence; the dimension of circumstance, and the dimension of imagination.
Antoni Gaudí in Human Flourishing
Authors: Tarragona i Clarasó Josep Maria 
Published: November 2022

AbstractThe great architect Antoni Gaudí i Cornet (1852–1926) is one of the shining lights of humanity on its path to social and individual perfection.Through his works, his life, and his teaching to his disciples and collaborators, we can easily describe a real form of human flourishing. Millions of people from every corner of the world are interested in the works of Gaudí and the positive impact it has on humanity.In this chapter, first we discuss human flourishing in the life and the teachings to his disciples of Gaudí, how Antoni Gaudí achieved his own flourishing; secondly, we indagate about how his art works are contributing to the flourishing of millions of human beings and, finally, we illustrate our opinions with three examples of Gaudí’s works which demonstrate to others ways to flourish themselves.
An Affective Neuroscience Perspective on Psychological Flourishing: How the Brain Believes that Things Are Going Well
Authors: Waugh Christian E. 
Published: November 2022

AbstractTo establish a “neuroscience of flourishing” one must first boil down its definition to only feature psychological concepts and then build a definition based on what the brain does. The “trait” perspective treats flourishing as a trait of the person that is reflected by forms of brain structure and/or patterns of neural functioning. The “behavioral” perspective emphasizes the brain as doing the behaviors that flourishing people do. I spend more time fleshing out the “belief” perspective, which is the brain’s representions of ‘having flourishing. In particular, the ventromedial prefrontal cortex (vmPFC) forms these flourishing beliefs by generating positive evaluations of life circumstances (e.g., life satisfaction), the self (e.g., self-esteem), relationships (e.g., relationship satisfaction), and goal progress (e.g., purpose). This “belief” neuroscientific perspective on flourishing is parsimonious, helps explain the overlapping yet distinct features of hedonic and eudaimonic flourishing, and forms the basis for neurologically constrained psychological models of flourishing.