bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upregulation of Beta 1 and Arachidonic Acid Metabolizing Enzymes in the
Mouse Hearts and Kidneys after Sub Chronic Administration of Rofecoxib
Authors: Jarrar Yazun , Askar Noor , Gharaibeh Munir , Alqudah Mohammad 
Published: April 2022

Background:
An imbalance in the levels of arachidonic acid (ARA) metabolites in cardiovascular
disorders and drug-induced cardiotoxicity have been previously described.

Aims:
This study aimed to investigate the influence of cyclooxygenase-2 (COX-2) selective inhibitors on
the gene expression of ARA-metabolizing genes and beta1 gene in the hearts and kidneys of experimental
mice.

Methods:
Thirty-five balb/c mice were divided into five groups with seven mice per group. The groups
were then given two distinct types of COX-2 selective inhibitors, rofecoxib and celecoxib, in two different
doses equivalent to those used in human treatment for 30 days. The mRNA expression of beta1, ace2, and
ARA-metabolizing genes, coxs, lipoxygenases (aloxs), and cytochrome p450 (cyp450s) in mice heart and
kidneys were assessed. Genes were analyzed using real-time polymerase chain reaction analysis. In addition,
rofecoxib-induced histological alterations were examined.

Results:
It was found that only the high dose of rofecoxib (5 mg/kg) caused toxicological alterations, a
finding that was indicated by a significant increase (P < 0.05) in the relative weight of the mouse hearts
and increase in the ventricle wall thickness as observed through pathohistological examination. This increase
was associated with a significant increase in the mRNA expression level of the beta1 receptor in
both the heart and kidneys of the mice (53- and 12-fold, respectively). The expression of both cox1 and
2 genes was increased 4-fold in the kidneys. In addition, the expression of the alox12 gene increased
significantly (by 67-fold in the heart and by 21-fold in the kidney), while alox15 gene expression was
upregulated in the heart by 8-fold and 5-fold in the kidney. The genes responsible for synthesizing 20-
Hydroxyeicosatetraenoic acid (cyp4a12 and cyp1a1) were significantly upregulated (P < 0.05) in the
hearts of high-dose rofecoxib-treated mice by 7- and 17 -fold, respectively. In addition, the expression of
epoxyeicosatrienoic acid-synthesizing genes, cyp2c29 and cyp2j5, was increased significantly (P < 0.05)
in the hearts of high-dose rofecoxib-treated mice by 4- and 16-fold, respectively.

Conclusion:
Rofecoxib caused upregulation of the mRNA expression of the beta 1 gene in association
with increased expression of ARA-metabolizing genes in mouse hearts and kidneys. These findings may
help us understand the molecular cardiotoxic mechanism of rofecoxib.
Mechanical Energy Harvesting System from the Human Arm Movement
for Continuous Blood Pressure Measurement
Authors: Lifi Houda , Alaoui-Belghiti Amine , Lifi Mohamed , Khrissi Salam , Nossir Naima , Tabbai Yassine , Benjellοun Mohammed 
Published: April 2022

Background:
In this article, an approach to harvesting electrical energy from a mechanically
excited piezoelectric element has been described. Three PMN-xPT compositions were used with x
taking the values of 0.31, 0.33, and 0.35 in order to study the most important properties of piezoelectric
PMN-PT in energy harvesting.

Objectives:
This study uses a detailed analysis of three Relaxer (1-x)PMN-xPT ceramic compositions,
emphasizing the influence of content on piezoelectric, dielectric, and electromechanical characteristics.

Methods:
Prototypes have been made and characterized, validating these energy thresholds. From this
comparative analysis of the three compositions, it was found that PMN-35PT has the highest recoverable
energy density. On the other hand, the pressure change in the radial artery was calculated using
the pressure sensitivity of the sensor and systolic and diastolic characteristic points in the pressure
pulse wave (PPW).

Results:
The results show that piezoelectric, dielectric, and electromechanical properties are all directly
associated with chemical composition and that the examined ceramics outperform their PZT counterparts,
making them very suitable for energy harvester systems and sensing device applications.
Therefore, the structure developed is an external patch of 5x3cm², placed on the arm and able to recover
3.46 mW for PMN-35PT during human walking.

Conclusion:
Results indicate that the suggested method demonstrated reliable accuracy of systolic
blood pressure (SBP). The technology has the potential to be used for long-term continuous blood
pressure monitoring. The piezoelectric sensor was placed on the skin above the radial artery and
measured for 10 sec to obtain the continuous pressure waveform.
Pathogenic Roles of m6A Modification in Viral Infection and Virus-driven Carcinogenesis
Authors: Wang Jia-Feng , Cai Wei , Qiu Fen-Sheng , Yu Chen-Huan 
Published: April 2022

Abstract:
N6-methyladenosine (m6A) is a prevalent modification of RNA in eukaryotes,
bacteria, and viruses. It is highly conserved and can affect the structure, localization, and
biology functions of RNA. In recent years, multiple m6A methylation sites have been identified
in the viral RNA genome and transcripts of DNA viruses. This modification occurs commonly
during the primary infection and is dynamically regulated by a methyltransferase (writers),
demethylase (eraser) and m6A-binding proteins (readers) within the host cells. The abnormal
m6A modification not only affects the replication of pathogenic viruses and host immune
response but also contributes to the pathogenesis of virus-induced cancers. In this review, we
highlight recent advances on the mechanism of m6A modification on viral replication, host
immune response and carcinogenesis to provide a novel insight for epigenetic prevention of
viral infection and virus-driven carcinogenesis.
Veterinary house officer perceptions of dimensions of well-being during postgraduate training
Authors: McPhetridge Jourdan B. , Scharf Valery F. , Dickson Rachel , Thieman Kelley M. , Oblak Michelle L. , Regier Penny J. , Skinner Owen T. , Tinga Selena , Townsend Katy L. , Wallace Mandy L. , Walton Rebecca , Marks Steven L. , Nelson Laura 
Published: April 2022

Abstract

OBJECTIVE
To describe veterinary house officers’ perceptions of dimensions of well-being during postgraduate training and to identify potential areas for targeted intervention.

SAMPLE
303 house officers.

PROCEDURES
A 62-item questionnaire was generated by use of an online platform and sent to house officers at participating institutions in October 2020. Responses were analyzed for trends and associations between selected variables.

RESULTS
239 residents, 45 rotating interns, and 19 specialty interns responded to the survey. The majority of house officers felt that their training program negatively interfered with their exercise habits, diet, and social engagement. House officers reported engaging in exercise significantly less during times of clinical responsibility, averaging 1.6 exercise sessions/wk (SD ± 0.8) on clinical duty and 2.4 exercise sessions/wk (SD ± 0.9) when not on clinical duty (P < 0.001). Ninety-four percent of respondents reported experiencing some degree of anxiety regarding their physical health, and 95% of house officers reported feeling some degree of anxiety regarding their current financial situation. Overall, 47% reported that their work-life balance was unsustainable for > 1 year; there was no association between specialty and sustainability of work-life balance. Most house officers were satisfied with their current training program, level of clinical responsibility, and mentorship.

CLINICAL RELEVANCE
Veterinary house officers demonstrated a poor balance between the demands of postgraduate training and maintenance of personal health. Thoughtful interventions are needed to support the well-being of veterinary house officers.
Endoscope-controlled extended supraorbital keyhole approach through a modified eyebrow incision for a large dural-based solitary fibrous tumor of the frontal convexity: A technical note
Authors: Azab Waleed , Najibullah Mustafa , Waheed Ghada 
Published: April 2022

Background:
The extended supraorbital approach through a modified eyebrow incision is a minimally invasive approach that has been recently described. It entails a lateral extension of the skin incision beyond the lateral end of the eyebrow and allows exposure of the proximal sylvian fissure with a superior degree of surgical freedom in the middle fossa and the parasellar region. In this technical note, we describe an endoscope-controlled extended supraorbital keyhole approach with modified eyebrow incision for excision of a large dural-based solitary fibrous tumor of the left frontal convexity.

Methods:
An endoscope-controlled extended supraorbital keyhole approach with modified eyebrow incision was performed to excise a large extra-axial mass attached to the dura of the left frontal convexity and extends from the superior temporal line up to the midline in a 34-year-old male patient presented with 1-year history of headache, dizziness, and blurred vision.

Results:
The patient had an uneventful postoperative course with gross total excision of the lesion and satisfying cosmetic appearance. Histopathological examination revealed a Grade 1 solitary fibrous tumor.

Conclusion:
We demonstrated the feasibility of the endoscope-controlled extended supraorbital keyhole approach through a modified eyebrow incision for excision of tumors that abut the inner table of the frontal calvarial bone, extend highly above the skull base level, or extend medially reaching the midline. The approach is very versatile and allows a great exposure for a category of lesions deemed not perfectly suitable for the classic supraorbital keyhole approach.
Truncal dystonia with isolated middle cerebral artery ischemia: A case report of revascularization therapy for dystonia
Authors: Matsumoto Shinichi , Yamamoto Yuki , Fujita Koji , Miyamoto Ryosuke , Koizumi Hidetaka , Tateishi Akihiro , Yamada Naoaki , Izumi Yuishin 
Published: April 2022

Background:
Dystonia is a rare movement disorder with some cases being difficult to treat. Although dystonia can occur as a symptom of moyamoya disease, few studies have reported truncal dystonia occurring with middle cerebral artery (MCA) stenosis. Here, we report a case of truncal dystonia with MCA occlusion.

Case Description:
The patient was a 48-year-old female clerical worker who lived alone. An abnormal cervical posture initially appeared 7 years before (right flexion). Symptoms improved with medication and botulinum toxin injection. Five years before this report, her symptoms worsened, so the dose of oral medication was increased and botulinum treatment was performed, but the symptoms did not improve. The patient showed decreased cerebral blood flow (CBF) in the cortical areas but not in the basal ganglia. We performed superficial temporal artery-MCA bypass surgery because we believed that the dystonia was due to right MCA stenosis. The patient’s symptoms improved immediately after surgery, except for her mild cervical backbend. Seven months after the surgery, the patient’s involuntary movements showed further improvement, and symptoms have not worsened even after 2 years.

Conclusion:
Revascularization therapy improved CBF and truncal dystonia and could be a viable treatment option for dystonia with ischemia in the MCA region. Extensive cerebral ischemia can result in cortical inhibition loss or over-adapted cerebral plasticity and cause dystonia. Revascularization therapy may be useful for patients with dystonia and decreased CBF in the MCA region.
Remote bifrontal epidural hematoma following hemispheric glioma resection. A rare life-threatening postoperative complication
Authors: Akhaddar Ali , Bellasri Salah , Belhadj Ayoub , Baallal Hassan 
Published: April 2022

Background:
Postoperative acute epidural hematoma (EDH) is a well-known serious complication that usually occurs at the operated site after cranial surgery. However, epidural bleeding, distant from the site of the previous craniotomy, is relatively rare and may sometimes cause significant neurological morbidity or even mortality. We report such a case.

Case Description:
A 35-year-old woman, previously healthy, was operated on for a left temporo-parieto-fronto-insular anaplastic astrocytoma. Between 2 and 4 h after the surgery, the patient had trouble waking-up following the general anesthesia. Emergent computed tomography (CT) scan revealed an acute bifrontal EDH away from the initial surgical field. The patient underwent an immediate reoperation, a decompressive bifrontal craniotomy, and the evacuation of the hematoma. Despite the neurologic improvement, she died 24 days after the surgery due to severe sepsis caused by pulmonary infection with pseudomonas aeruginosa.

Conclusion:
The pathophysiology of postoperative remote EDH is poorly understood, although various hypotheses have been suggested including the loss of tamponade effect, the vasomotor mechanisms, and the coagulopathy. As seen in the present case report, we suspected that the intensive use of perioperative mannitol may also promote this complication. In the early postoperative period, every patient with neurological deterioration should have a rapid cranial CT-scan because early detection and removal of postoperative acute EDH can be life-saving.
Periosteum-induced ossification effect in skull defect through interleukin-8 and NF-κB pathway: An experimental study with Oryctolagus cuniculus rabbits
Authors: Apriawan Tedy , Widjiati Widjiati , Utomo Dwikora Novembri , Fauzi Asra Al , Subagio Eko Agus , Utomo Budi , Islam Andi Asadul , Bajamal Abdul Hafid , Sudiana I. Ketut 
Published: April 2022

Background:
The purpose of this study was to analyze the response of inflammatory cytokines interleukin-8 (IL-8) and NF-κB to the closure of skull defect with periosteum as a scaffolding material in bone healing used after surgery.

Methods:
Thirty Oryctolagus cuniculus rabbits underwent a craniotomy to create a 20 mm diameter round defect in the parietal bones. The parietal bones were returned to its place and stabilized by an internal plate fixation. The defects were either left empty or implanted with periosteum. At 6 weeks, the specimens were euthanized and examined.

Results:
Histological examination showed a more well-developed formation of woven bone in the periosteum group. Immunohistochemical examinations showed that the use of periosteum in the closure of skull defects reduced the NF-κB and IL-8 response which affected the ossification process.

Conclusion:
The experiment showed that the use of periosteum was linked with IL-8 and NF-κB downregulation toward ossification effects at any point throughout the trial. Periosteum usage might be beneficial as a scaffolding material in bone healing for autograft cranioplasty in animal model and could be applied to clinical practice.
Intracranial ancient schwannoma originating from vestibular nerve: A case report and review of the literature
Authors: Tsuchiya Takahiro , Miyawaki Satoru , Shinya Yuki , Teranishi Yu , Tomioka Arisa , Yamazawa Sho , Shin Masahito , Saito Nobuhito 
Published: April 2022

Background:
Ancient schwannoma (AS) is a subtype of schwannoma with degenerative features, which often progresses slowly over a long period of time. Intracranial AS is a rare benign tumor and there are no detailed reports of AS originating from the vestibular nerve.

Case Description:
Herein, we present the case of a patient with the right vestibular schwannoma with multiple meningiomas and review three previous cases of intracranial AS. Near-total resection was performed for vestibular schwannoma and the pathological findings were AS (World Health Organization Grade I). Five months postoperatively, gamma knife radiosurgery was performed for a recurrent lesion of the right vestibular schwannoma in the internal auditory meatus. Although AS is known to be a benign pathology, there are cases of rapid growth and early recurrence, as the one presented here. The high Ki-67 index (up to 5%) and the presence of cysts may be related to the rapid progression of intracranial AS.

Conclusion:
Therefore, careful follow-up is necessary even if adequate removal is achieved. In addition to pathological studies, the genetic background of intracranial AS warrants future investigations. Further accumulation of cases is necessary to clarify the clinical features of intracranial AS.
Implications and limitations of magnetic resonance perfusion imaging with 1.5-Tesla pulsed arterial spin labeling in detecting ictal hyperperfusion during non-convulsive status epileptics
Authors: Goto Katsuhiro , Shimogawa Takafumi , Mukae Nobutaka , Shono Tadahisa , Fujiki Fujio , Tanaka Atsuo , Sakata Ayumi , Shigeto Hiroshi , Yoshimoto Koji , Morioka Takato 
Published: April 2022

Background:
Recent our reports showed that 3-T pseudocontinuous arterial spin labeling (3-T pCASL) magnetic resonance perfusion imaging with dual post labeling delay (PLD) of 1.5 and 2.5 s clearly demonstrated the hemodynamics of ictal hyperperfusion associated with non-convulsive status epilepticus (NCSE). We aimed to examine the utility of 1.5-T pulsed arterial spin labeling (1.5-T PASL), which is more widely available for daily clinical use, for detecting ictal hyperperfusion.

Methods:
We retrospectively analyzed the findings of 1.5-T PASL with dual PLD of 1.5 s and 2.0 s in six patients and compared the findings with ictal electroencephalographic (EEG) findings.

Results:
In patients 1 and 2, we observed the repeated occurrence of ictal discharges (RID) on EEG. In patient 1, with PLDs of 1.5 s and 2.0 s, ictal ASL hyperperfusion was observed at the site that matched the RID localization. In patient 2, the RID amplitude was extremely low, with no ictal ASL hyperperfusion. In patient 3 with lateralized periodic discharges (LPD), we observed ictal ASL hyperperfusion at the site of maximal LPD amplitude, which was apparent at a PLD of 2.0 s but not 1.5 sec. Among three patients with rhythmic delta activity (RDA) of frequencies <2.5 Hz (Patients 4–6), we observed obvious and slight increases in ASL signals in patients 4 and 5 with NCSE, respectively. However, there was no apparent change in ASL signals in patient 6 with possible NCSE.

Conclusion:
The detection of ictal hyperperfusion on 1.5-T PASL might depend on the electrophysiological intensity of the epileptic ictus, which seemed to be more prominent on 1.5-T PASL than on 3-T pCASL. The 1.5-T PASL with dual PLDs showed the hemodynamics of ictal hyperperfusion in patients with RID and LPD. However, it may not be visualized in patients with extremely low amplitude RID or RDA (frequencies <2.5 Hz).
Implementasi Keputusan Bupati Rokan Hulu Nomor 250 Tahun 2011 Tentang Pembentukan Tim Sekretariat Tim Intensifikasi Pajak Bumi Dan Bangunan Di Kabupaten Rokan Hulu
Authors: Armiati  , Nurman  
Published: April 2022

Sesuai dengan Undang-Undang Nomor 12 Tahun 1994 tentang Pajak Bumi dan Bangunan, dimana pada pasal 3 ayat (2) Pajak Bumi dan Bangunan adalah Pajak Negara yang sebagian besar penerimaannya merupakan pendapatan daerah dan berdasarkan Keputusan Menteri Keuangan Republik Indonesia Nomor 1007/KMK.04/1985 Tentang Pelimpahan Kewenangan Penagihan Pajak Bumi dan Bangunan kepada Gubernur Kepala Daerah Tingkat I dan /atau Bupati / Walikota Kepala Daerah Tingkat II. Permasalahan dirumuskan dalam pertanyaan penelitian: “Bagaimana Implementasi Keputusan Bupati Rokan Hulu Nomor 250 Tahun 2011 Tentang Pembentukan Tim dan Sekretariat Tim Intensifikasi Pajak Bumi Dan Bangunan?”Penulis mencoba menjawabnya melalui penelitian dengan menggunakan metode deskriptif kualitatif. Dari hasil penelitian dapat disimpulkan bahwa Dalam implementasi Pembentukan Tim dan Sekretariat Tim Intensifikasi Pajak Bumi Dan Bangunan ini dapat disimpulkan: 1) Ukuran dan tujuan kebijakan belum dapat tercapai sesuai dengan target, 2) Sumber-sumber Kebijakan sudah berjalan sesuai dengan ketentuan peraturan perundang-undangan yang berlaku, 3) Aspek Ciri-ciri sifat badan/instansi pelaksana belum secara baik terlaksana dimana KPP Pratama Bangkinang belum mampu memberikan pelayanan khususnya terhadap pemuktahiran data pajak, 4) Komunikasi antar KPP Pratama Bangkinang dan aparat pemerintah kabupaten Rokan Hulu tidak berjalan dengan baik hal ini disebabkan luasnya wilayah kerja KPP Pratama Bangkinang. 5) Sikap aparat pelaksana yang harus ditingkatkan dengan mengadakan pelatihan dan pemotivasian agar setiap staf dapat melaksanakan kegiatan secara optimal sesuai dengan peran, tugas dan tanggungjawabnya. 6) Tingginya pengaruh aspek sosial, ekonomi dan politik dalam implementassinya.. Pelaksanaan sistem perpajakan ini dalam implementasinya belum terlaksana secara optimal.
The Effectiveness of Lactobacillus plantarum Administration in Patients with Atopic Dermatitis
Authors: Izzati Ismatu Aghni Fatwa , Pramuningtyas Ratih , Bestari Rochmadina Suci , Nurhayani Nurhayani 
Published: April 2022

Background: Atopic dermatitis is a chronic and residual inflammatory skin disease with increased prevalence in every year. The medications that are often given can cause serious side effects if it given in the long-term. The treatment of Lactobacillus plantarum is expected to be safer long-term treatment option for patient with atopic dermatitis.Objective: The objective is to determine the effectiveness treatment of Lactobacillus plantarum in patients with atopic dermatitis.Method: The research design was a Systematic Review with a qualitative approach using meta-synthesis analysis type. The search was conducted on 3 databases: PubMed, Science Direct, and Google Scholar. Result: Total articles obtained were 239 with 16 duplicate data. 211 articles were included in the exclusion criteria and 5 articles were interventions with combination probiotics. So there are 7 articles included in the research with clinical trials, open trials, pilot studies, and 4 research using the randomized controlled trial Double Blind design. All results showed improvement in symptoms with the SCORAD index or Skindex-16. Several studies also measured IgE, IL-4, IL-10, IL-13, IL-17, the percentage of Th1, Th2, Treg, TGF-β, IFN-γ and obtained different results. Conclusion: Treatment of Lactobacillus plantarum in patients with atopic dermatitis is effective to reducing symptoms and as an immunomodulator.