bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Study on the Wave Effect on Maneuvering Hydrodynamic Derivatives
Authors: Ma Chengqian , Ma Ning , Gu Xiechong 
Published: July 2022

Abstract
For maneuverability in waves, all the current theoretical methods rely on an unverified hypothesis that the hydrodynamic derivatives in waves are consistent with those in calm water. Many scholars attribute the errors between the predicted motions using the theoretical methods and the experimental motions to this irrational hypothesis. To explore the rationality of the hypothesis and improve the theoretical methods, the planar motion mechanism tests of KVLCC2 in calm water and regular head waves were carried out in the towing tank. Different components of the hull forces are obtained by the fast Fourier transform technique. Then, maneuvering hydrodynamic derivatives in calm water and head waves are calculated to assess the wave effect on them quantitatively. The results reveal that the wave effect on Yv′, Nr′ and the high-order derivatives are obvious, and the influence on Nr′ and Yv′ is small. This finding sheds light on the error of the earlier hypothesis and is conducive to the improvement of potential flow methods in the future.
A Simplified Model for Numerical Investigation of Bump-Type Foil Bearings Based on Contact Nonlinearity
Authors: Zhang Yan , Xiao Shuhong 
Published: July 2022

Abstract
The paper introduces a simplified structural model for the numerical investigation of bump-type foil bearings. This analytical model is based on an efficient nonlinear contact procedure with consideration of friction, small deformations, and elasticity. The bump foil is modeled with a truss structure, while the top foil uses two-dimensional (2D) beam elements. In this present model, the normal and tangential contact forces between the bump foil and the bearing sleeve and between the foils are dealt with the penalty method. Even for a simple loading, the contact state might change between separation, stick, and slip. To avoid convergence problems caused by discontinuity, the regularized smooth friction model is used instead of the Coulomb friction model. In addition, due to contact problems that depend on time are accompanied by nonlinear evolution, the solution of the system equation using the incremental iterative method and the Newton–Raphson method is presented. The deflection of the top foil is added to the film controlled by the Reynolds equation (RE) to obtain the air pressure distribution. The theoretical predictions of the rotor push-pull tests agree well with results from the literature, which verifies the validity of the model. Using this present model, the quasi-static behaviors of the foil structure are mainly discussed, and parametric studies concerning environmental pressure and radial clearance are also conducted.
New faunistical data on oribatid mites from the Maldives, with description of a new species of Aeroppia (Acari, Oribatida, Oppiidae) and a key to known species of the genus
Authors: Ermilov Sergey G. , Joharchi Omid 
Published: July 2022

This paper presents a list of 24 species of 24 genera and 14 families of soil-inhabiting oribatid mites (Oribatida) in Republic of Maldives. Aeroppia maldivesensis sp. nov. (Oppiidae) is described on the basis of adults. An identification key to all known species of the genus Aeroppia is provided.
Supplemental Material: Structure, chronology, kinematics, and geodynamics of tectonic extension in the greater Catalina metamorphic core complex, southeastern Arizona, USA
Authors: Spencer J.E. , al. et 
Published: July 2022

<p>Item S1: Mylonitic lineation and foliation data. Item S2: Summary of geochronologic dates and sources. Item S3: New U-Pb geochronologic data. </p>
A randomised trial comparing weaning from CPAP alone with weaning using heated humidified high flow nasal cannula in very preterm infants: the CHiPS study
Authors: Clements Joanne , Christensen Pernille M , Meyer Michael 
Published: July 2022

ObjectiveTo determine whether weaning from nasal continuous positive airway pressure (nCPAP) using heated humidified high flow nasal cannula (nHF) was non-inferior to weaning using nCPAP alone in relation to time on respiratory support.Study designSingle-centre, non-inferiority, randomised controlled trial.SettingNeonatal Intensive Care Unit, Middlemore Hospital, Auckland, New Zealand.Patients120 preterm infants, <30 weeks’ gestation at birth, stable on nCPAP for at least 48 hours.InterventionsInfants underwent stratified randomisation to nHF 6 L/min or bubble CPAP 6 cm water. In both groups, stepwise weaning of their respiratory support over 96 hours according to a strict weaning protocol was carried out.Main outcome measuresTime on respiratory support from randomisation to 72 hours off respiratory support or 36 weeks’ postmenstrual age. The non-inferiority threshold was set at 15%.Results59 infants were randomised to weaning using nHF and 61 using nCPAP. The groups were well balanced in regards to baseline demographics. The restricted mean duration of respiratory support following randomisation for the nCPAP group, using per-protocol analysis was 401 hours (upper boundary, mean plus 0.15, was 461 hours) and 375 hours in the nHF group (upper 95% CI 413 hours). nHF weaning was, therefore, non-inferior to nCPAP weaning at the non-inferiority threshold. There was no significant difference in time to discharge.ConclusionFor infants ready to wean from nCPAP, the CHiPS study found that nHF was non-inferior to discontinuing nCPAP at 5 cm water.Trial registration numberAustralia and New Zealand Clinical Trials Registry (ACTRN12615000077561).
Temporal trends and differences of SARS-CoV-2-specific antibody responses in symptomatic and asymptomatic subjects: a longitudinal study from Umbria in Italy
Authors: Abraha Iosief , Eusebi Paolo , Germani Antonella , Pasquarelli Erica , Pascolini Sofia , Antonietti Rossana , Argenti Sandro , Fioravanti Alessandra , Martini Elisa , Aristei Luana , Mancinelli Paola , Ottaviani Maria Letizia , Roselli Martina , Barzacca Milena , Belardinelli Erika , Micheli Marta 
Published: July 2022

ObjectivesDynamics of antibody responses following SARS-CoV-2 infection are controversial in terms of immunity and persistence. We aimed to assess longitudinally the trend of antibody serological titres, their correlation with clinical severity as well as clinical reinfection during a follow-up.DesignLongitudinal cohort, 12 months follow-up study.SettingUSL Umbria 2.ParticipantsConsecutive subjects aged 15–75 who were discharged with the diagnosis of Sars-Cov-2 from the hospitals of the AUSL Umbria 2, or resulted positive to a PCR test for SARS-CoV-2 infection with or without symptoms were recruited. SARS-CoV-2 serological testing for antibodies targeting the Nucleocapside and Spike proteins were determined.ResultsOf 184 eligible subjects, 149 were available for evaluation: 17 were classified as oligo/asymptomatic, 107 as symptomatic, 25 as hospital admitted. Participants differed in terms of signs and symptoms as well as treatment. Overall there was a significant difference in terms of antibody titres between groups (anti-S: p<0.00; anti-N: p=0.019). Median anti-S titres in the symptomatic and hospital admitted participants were significantly higher compared with the oligo/asymptomatic participants. During follow-up, the median titre of anti-S antibodies did not show significant variations (p=0.500) and the difference within groups remained constant overtime. Subjects that showed an anti-S titre above the threshold of 12 U/mL were 88.7% at first visit and 88.2% at last follow-up. Anti-N values were higher in the hospital admitted participants compared with the other two groups. Anti-N titre reduced constantly overtime (p<0.001) and across the three groups of participants. The percentage of the subjects with serological titre above threshold (<1.4 U/mL) decreased from 74.5%% to 29.2% (p<0.001). None of the participants developed clinically evident reinfection.ConclusionAnti-N and anti-S correlate well with clinical severity. While anti-N declines overtime, anti-S antibodies persist for at least 1 year.
Active case detection and treatment of malaria in pregnancy using LAMP technology (LAMPREG): a pragmatic randomised diagnostic outcomes trial—study protocol
Authors: Gebresenbet Rediet Fikru , Kamaliddin Claire , Bekele Zelalem Mekonnen , Teferi Mekonnen , Tegegne Banchamlak , Yewhalaw Delenasaw , Bayih Abebe Genetu , Pillai Dylan R 
Published: July 2022

IntroductionMalaria is one of the major public health problems in sub-Saharan Africa. It contributes significantly to maternal and fetal morbidity and mortality in affected countries. This study aims to evaluate the impact of enhanced case detection using molecular testing called loop-mediated isothermal amplification (LAMP) on birth outcomes in a prospective study design.Methods and analysisA pragmatic randomised diagnostic outcomes trial will be conducted in several health institutes in different Ethiopian regions. Women (n=2583) in their first and second trimesters of pregnancy will be included in the study and individually randomised to the standard of care or enhanced case detection arms, and followed until delivery. Enrolment will encompass the malaria peak transmission seasons. In the standard of care arm, a venous blood sample will be collected for malaria diagnosis only in symptomatic patients. In contrast, in the intervention arm, mothers will be tested by a commercially available Conformité Européene (CE)-approved LAMP malaria test, microscopy and rapid diagnostic test for malaria regardless of their symptoms at each antenatal care visit. The primary outcome of the study is to measure birth weight.Ethics and disseminationThe study was approved by the following ethical research boards: Armauer Hansen Research Institute/ALERT Ethics Review Committee (FORM AF-10-015.1, Protocol number PO/05/20), the Ethiopia Ministry of Science and Higher Education National Research Ethics Review Committee (approval SRA/11.7/7115/20), the Ethiopia Food and Drug Administration (approval 02/25/33/I), UCalgary Conjoint Health Research Ethics Board (REB21-0234). The study results will be shared with the institutions and stakeholders such as the Ethiopia Ministry of Health, the Foundation for Innovative Diagnostics, WHO’s Multilateral initiative on Malaria - Tropical Diseases Research (TDR-MIM), Roll Back Malaria and the Malaria in Pregnancy Consortium. The study results will also be published in peer-reviewed journals and presented at international conferences.Trial registration numberNCT03754322.
Deep learning for automatic brain tumour segmentation on MRI: evaluation of recommended reporting criteria via a reproduction and replication study
Authors: Gryska Emilia , Björkman-Burtscher Isabella , Jakola Asgeir Store , Dunås Tora , Schneiderman Justin , Heckemann Rolf A 
Published: July 2022

ObjectivesTo determine the reproducibility and replicability of studies that develop and validate segmentation methods for brain tumours on MRI and that follow established reproducibility criteria; and to evaluate whether the reporting guidelines are sufficient.MethodsTwo eligible validation studies of distinct deep learning (DL) methods were identified. We implemented the methods using published information and retraced the reported validation steps. We evaluated to what extent the description of the methods enabled reproduction of the results. We further attempted to replicate reported findings on a clinical set of images acquired at our institute consisting of high-grade and low-grade glioma (HGG, LGG), and meningioma (MNG) cases.ResultsWe successfully reproduced one of the two tumour segmentation methods. Insufficient description of the preprocessing pipeline and our inability to replicate the pipeline resulted in failure to reproduce the second method. The replication of the first method showed promising results in terms of Dice similarity coefficient (DSC) and sensitivity (Sen) on HGG cases (DSC=0.77, Sen=0.88) and LGG cases (DSC=0.73, Sen=0.83), however, poorer performance was observed for MNG cases (DSC=0.61, Sen=0.71). Preprocessing errors were identified that contributed to low quantitative scores in some cases.ConclusionsEstablished reproducibility criteria do not sufficiently emphasise description of the preprocessing pipeline. Discrepancies in preprocessing as a result of insufficient reporting are likely to influence segmentation outcomes and hinder clinical utilisation. A detailed description of the whole processing chain, including preprocessing, is thus necessary to obtain stronger evidence of the generalisability of DL-based brain tumour segmentation methods and to facilitate translation of the methods into clinical practice.
Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study
Authors: Cao Guiying , Long Hai , Liang Yuedong , Liu Jue , Xie Xiaoxin , Fu Yanhua , He Juan , Song Su , Liu Siqi , Zhang Manna , Wu Yu , Wang Yaping , Du Min , Jing Wenzhan , Yuan Jie , Liu Min 
Published: July 2022

ObjectivesTo estimate anaemia prevalence and the associated factors among hospitalised people living with HIV (PLHIV) receiving antiretroviral therapy (ART).DesignA cross-sectional study.SettingPLHIV receiving ART and hospitalised in a specialised hospital for infectious disease in Guizhou Province, Southwest China, between 1 January 2018 and 31 March 2021.ParticipantsA total of 6959 hospitalised PLHIV aged ≥18 years and receiving ART were included in this study.Primary and secondary outcome measuresAnaemia was diagnosed as a haemoglobin concentration <120 g/L for non-pregnant females and <130 g/L for males. Mild, moderate and severe anaemia were diagnosed as below the gender‐specific lower limit of normal but ≥110 g/L, 80–110 g/L and <80 g/L, respectively.ResultsThe prevalence of anaemia was 27.5%, and that of mild, moderate and severe anaemia was 9.2%, 12.2% and 6.1%, respectively. Results from multivariate logistic regression showed that females had increased odds of anaemia (adjusted OR (aOR)=1.60, 95% CI: 1.42 to 1.81) compared with males. Widowed or divorced inpatients (anaemia: aOR=1.26, 95% CI: 1.08 to 1.47; severe anaemia: aOR=1.52, 95% CI: 1.16 to 1.97) and thrombocytopenia inpatients (anaemia: aOR=4.25, 95% CI: 3.54 to 5.10; severe anaemia: aOR=4.16, 95% CI: 3.24 to 5.35) had increased odds of anaemia and severe anaemia compared with their counterparts. Hepatitis C was associated with increased odds of severe anaemia (aOR=1.80, 95% CI: 1.11 to 2.92).ConclusionsAnaemia was prevalent among hospitalised PLHIV. Female sex, those widowed or divorced, and thrombocytopenia were associated with increased odds of anaemia, and those widowed or divorced, thrombocytopenia and hepatitis C were associated with increased odds of severe anaemia. Determination of anaemia predictors, early detection and timely management of anaemia are crucial to prevent anaemia progression.
Development of hypertensive complications in oocyte donation pregnancy: protocol for a systematic review and individual participant data meta-analysis (DONOR IPD)
Authors: van Bentem Kim , van der Hoorn Marie-Louise , van Lith Jan , le Cessie Saskia , Lashley Eileen 
Published: July 2022

IntroductionThe assisted reproductive technique of oocyte donation (OD) is comparable to in vitro fertilisation (IVF), with the distinction of using a donated oocyte and thus involving two women. Compared with IVF and naturally conceived (NC) pregnancies, OD pregnancies have a higher risk for pregnancy complications as pregnancy-induced hypertension (PIH) and pre-eclampsia (PE). Various covariates among women pregnant by OD, however, also contribute to an increased risk for developing hypertensive complications. Therefore, we will conduct the DONation of Oocytes in Reproduction individual participant data (DONOR IPD) meta-analysis to determine the risk for the development of hypertensive complications in OD pregnancy, in comparison to autologous oocyte pregnancy (non-donor IVF/intracytoplasmic sperm injection (ICSI) and NC pregnancy). The DONOR IPD meta-analysis will provide an opportunity to adjust for confounders and perform subgroup analyses. Furthermore, IPD will be used to externally validate a prediction model for the development of PE in OD pregnancy.Methods and analysisA systematic literature search will be performed to search for studies that included women pregnant by OD, and documented on hypertensive complications in OD pregnancy. The authors from each study will be asked to collaborate and share IPD. Using the pseudoanonymised combined IPD, we will perform statistical analyses with one-stage and two-stage approaches, subgroup analyses and possibly time-to-event analyses to investigate the risk of developing hypertensive complications in OD pregnancy. Furthermore, we will formally assess a prediction model on its performance in an external validation with the use of IPD.Ethics and disseminationEthical approval and individual patient consent will not be required in most cases since this IPD meta-analysis will use existing pseudoanonymised data from cohort studies. Results will be disseminated through peer-reviewed journals and international conferences.PROSPERO registration numberCRD42021267908.
Cohort profile: the Liyang cohort study on chronic diseases and risk factors monitoring in China (Liyang Study)
Authors: Zhou Liang , Hu Wei , Liu Siyuan , Qiao Yanan , He Dingliu , Xiong Shuting , Peng Liuming , Cao Lei , Wu Ying , Sun Na , Han Qiang , Chu Jiadong , Chen Xuanli , Li Tongxing , Feng Zhaolong , He Qida , Ke Chaofu , Shen Yueping 
Published: July 2022

PurposeThe Liyang cohort study on chronic diseases and risk factors monitoring in China (Liyang Study) is a prospective population-based study which aims to investigate and identify the determinants of the most prevalent chronic non-communicable diseases (NCDs) and to evaluate the impact of demographic characteristics, lifestyle, dietary habits, cognition, disability and NCDs on the health-related quality of life.ParticipantsBetween March 2019 and June 2020, 10 056 individuals aged ≥18 years were administered a baseline survey through a multistage cluster random sampling in Liyang City, southern Jiangsu Province, China.Findings to dateThe Liyang Study included detailed sociodemographic, anthropometric and health-related behaviour, common NCDs and blood sample information. Moreover, the study gathered a series of data on specific scales including the activities of daily living, instrumental activities of daily living, abbreviated mental test, Food Frequency Questionnaire and EuroQol 5-Dimensions 5-Levels Scale. Of the 10 056 participants, 52.92% (n=5322) were female and 92.26% (n=9278) came from rural areas. The mean age was 49.9±16.2 years. Men were more likely to have a higher level of education, annual income and a paid job than women (p<0.05). The top three overall most prevalent NCDs in the study were hypertension (18.06%, n=1815), digestive diseases (7.88%, n=791), and arthritis or rheumatism (5.28%, n=530). Women had a significantly higher prevalence of diabetes (5.46%, n=290 vs 4.42%, n=209, p=0.016) and arthritis (6.04%, n=321 vs 4.42%, n=209, p<0.001) than men, while the opposite was true for chronic lung diseases such as chronic obstructive pulmonary disease (1.37%, n=65 vs 0.92%, n=49, p=0.032) and chronic hepatic diseases (0.80%, n=38 vs 0.47%, n=25, p=0.035).Future plansThe current study will give valuable insights into the association between sociodemographic factors, health-related behaviour, diet, cognition, disability and genetic factors and the most prevalent NCDs among local community residents. Starting from 2022, a follow-up survey will be conducted every 3 years to further explore the causal relationship between the above factors and NCDs.
Predictors of mortality after atrial correction of transposition of the great arteries
Authors: Antonová Petra , Rohn Vilem , Chaloupecky Vaclav , Simkova Iveta , Kaldararova Monika , Zeman Jan , Popelova Jana , Havova Mariia , Janousek Jan 
Published: July 2022

ObjectivesTo determine the long-term and transplantation-free survival of all patients after atrial correction of transposition of the great arteries (TGA) in the Czech and Slovak republics, including its preoperative and perioperative determinants.MethodsRetrospective analysis of all 454 consecutive patients after atrial correction of TGA was performed. Of these, 126 (27.8%) were female, median age at operation was 7.4 months (Q1 5.3; Q3 13.3) and 164 (36.1%) underwent the Mustard procedure. The relationships between age, weight, the complexity of TGA, operative technique, additional surgical procedures, immediate postoperative presence of tricuspid regurgitation and revision procedures during follow-up to major composite outcome, as such defined as long-term and transplantation-free survival, were tested.ResultsEarly 30-day mortality did not differ between the Mustard (9.76%) and Senning (8.97%) cohorts (p=0.866). The long-term and transplantation-free survival, which differed between the Mustard and Senning cohorts in favour of the Senning procedure (HR 0.43; 95% CI 0.21 to 0.87), was shorter in complex TGA (HR 2.4; 95% CI 1.59 to 3.78) and in complex surgical interventions (HR 3.51; 95% CI 2.31 to 5.56). The immediate presence of at least moderate tricuspid regurgitation after correction was associated with a shorter long-term and transplantation-free survival in the univariate but not in the multivariable model.ConclusionsThe lower long-term survival of patients after an atrial switch operation of TGA in the Czech and Slovak republics is associated with greater complexity of TGA, complex surgical interventions and application of the the Mustard operative procedure.