bluuebunny/crossref_metadata_2025_split huggingface dataset:
Right coronary artery deformation and injury following tricuspid valve surgery
Authors: Gerçek Muhammed , Omran Hazem , Friedrichs Kai P. , Bleiziffer Sabine , Gummert Jan , Rudolph Volker , Deutsch Marcus A. , Rudolph Tanja K. 
Published: November 2022

BackgroundDue to its close anatomical proximity to the annular plane of the tricuspid valve (TV), the right coronary artery (RCA) is at risk of injury and distortion during surgical and interventional repair. Recently, reversible, non-flow limiting, purse-string like deformations of the RCA following percutaneous TV annuloplasty have been described. In contrast, there are only anecdotal reports on RCA deformation following conventional TV surgery.Materials and methodsA retrospective analysis of all patients undergoing TV surgery in our hospital between 2009 and 2019 was performed including all patients who received a post-operative coronary angiography (POCA). Angiographic footage was reviewed for RCA affections.ResultsA total of 1,383 patients underwent TV surgery (replacement and repair) for tricuspid regurgitation in our center. TV repair was performed in 1,248 (90.2%) patients and 135 (9.8%) patients underwent isolated TV surgery. Sixty-five patients (4.7%) underwent POCA within 48 h after surgery due to suspected myocardial ischemia, representing the final study population. Mean age was 70.3 ± 11.3 years, 56.3% were female. Mean EuroSCORE II was 9.8 ± 11.6%. Patients with the need for POCA due to suspected myocardial injury suffered from a higher mortality compared to event-free patients over the long-term follow up period (median 2.9 years) regardless of the observed coronary status. RCA affections were observed in 24 (36.9%) patients. A new RCA deformation without flow-impairment or vascular damage was found in 16 (24.6%) of the cases and was managed conservatively. There was no significantly worse outcome observed as compared to patients without RCA affections. Six (9.2%) patients showed an RCA deformation accompanied by subtotal occlusion. A complete RCA-occlusion was observed in 2 (3.1%) patients. Revascularization by percutaneous coronary intervention could be successfully performed in these patients. RCA deformation occurred exclusively after TV repair while no cases were observed after TV replacement.ConclusionRight coronary artery deformation without flow-limitation following surgical TV repair is a specific/typical phenomenon which might not impair patients’ outcome and could be managed conservatively in most of the cases. RCA injury indicating further interventional therapy is a rare complication of TV surgery. However, the need for immediate POCA in general appears to be associated with a worsened intermediate-term outcome.
A review of recent developments in low-frequency ultra-wideband microwave radiometry for studies of the cryosphere
Authors: Jezek K.C. , Johnson J.T. , Tsang L. , Brogioni M. , Macelloni G. , Aksoy M. , Kaleschke L. , Wang S. , Leduc-Leballeur M. , Yardim C. , Andrews M. , Xu H. , Demir O. , Tan S. , Miller J. 
Published: November 2022

Over the past decade, a series of airborne experiments in the Arctic and Antarctica explored microwave emission from sea ice and ice sheets at frequencies from 0.5 to 2 GHz. The experiments were motivated by the fact that lower frequencies penetrate deeper into a frozen surface, thus offering the possibility to measure physical temperatures at great depths in ice sheets and, subsequently, other unique geophysical observables including sea ice salinity. These experiments were made feasible by recent engineering advances in electronics, antenna design, and noise removal algorithms when operating outside of protected bands in the electromagnetic spectrum. These technical advances permit a new type of radiometer that not only operates at low frequency, but also obtains continuous spectral information over the band from 0.5 to 2 GHz. Spectral measurements facilitate an understanding of the physical processes controlling emission and also support the interpretation of results from single frequency instruments. This paper reviews the development of low-frequency, wide band radiometry and its application to cryosphere science over the past 10 years. The paper summarizes the engineering design of an airborne instrument and the associated algorithms to mitigate radio frequency interference. Theoretical models of emission built around the morphologic and electrical properties of cryospheric components are also described that identify the dominant physical processes contributing to emission spectra. New inversion techniques for geophysical parameter retrieval are summarized for both Arctic and Antarctic scenarios. Examples that illustrate how the measurements are used to inform on glaciological problems are presented. The paper concludes with a description of new instrument concepts that are foreseen to extend the technology into operation from space.
Knowledge atlas and emerging trends on ncRNAs of osteosarcoma: A bibliometric analysis
Authors: Wang Bo , Yang Chunhua , Zhou Chuqiao , Xiao Shipeng , Li Hui 
Published: November 2022

BackgroundOsteosarcoma is a common bone sarcoma that occurs in childhood and adolescence. Although research on non-coding RNAs (ncRNAs) of osteosarcoma has been developed rapidly in recent years, a specific bibliometric analysis on this topic has not yet been performed. The bibliometric analysis aims to summarize knowledge atlas, research hotspots, and emerging trends and to provide researchers with new perspectives in further studies.MethodsAll publications regarding ncRNAs of osteosarcoma published from 2000 to 2021 were retrieved from the Web of Science Core Collection. Quantitative indicators including the number of publications and citations, H-index, and journal citation reports were analyzed by using Excel 2019 and R software. VOSviewer and CiteSpace were used to analyze the cooperation among countries/institutions/journals/authors and the co-occurrence of keywords, keywords bursts, and references.ResultsA total of 3206 publications were extracted. A significant growth trend in the annual number of publications over the past 22 years is revealed (R2 = 0.999). The most prolific country and institution were China (2260) and Shanghai Jiao Tong University (134), respectively. Professors Wang W and Liu W contributed the most to this field. The keywords were stratified into six clusters: Cluster 1 (apoptosis and growth), Cluster 2 (cancer and progression), Cluster 3 (microRNAs and downregulation), Cluster 4 (genes and differentiation), Cluster 5 (expression and biological functions), and Cluster 6 (metastasis). The long non-coding RNAs and circular RNAs have been considered as an important research hotspot in the near future.ConclusionThis study offers a scientific perspective on ncRNAs of osteosarcoma and provides researchers with valuable information to understand the knowledge structure and to identify emerging trends in this field.
Long-term follow-up of surgical treatment of thyroid-associated orbitopathy restrictive strabismus
Authors: Savino Gustavo , Mattei Roberta , Salerni Annabella , Fossataro Claudia , Pafundi Pia Clara 
Published: November 2022

ObjectiveThyroid-associated orbitopathy (TAO) is the most frequent cause of extraocular muscle enlargement, with consecutive restrictive strabismus. The main muscles involved are inferior and medial rectus, resulting in horizontal esotropia and/or vertical strabismus. Surgery may either establish or improve binocular single vision. The aim of the present study is to describe long-term follow-up of patients who underwent horizontal or vertical TAO strabismus surgery.MethodsThis observational retrospective study included 29 patients suffering from either vertical or horizontal TAO strabismus and diplopia, of whom 11 underwent bilateral medial recti muscle recession (Group A) and 18 underwent unilateral inferior rectus muscle recession (Group B). The endpoint of the study was the assessment of changes in deviation angle and diplopia across four time points (baseline, 7 days, 6 months, and 24 months) in each group.ResultsIn Group A, the horizontal deviation angle significantly decreased 7 days after intervention (p &lt; 0.001), without modifications overtime. In Group B, both deviation angles in primary and down-gaze position significantly decreased from baseline, both 7 days after surgery (p &lt; 0.001) and at 6 months (p = 0.040). An overcorrection, with an inversion of vertical deviation angle, was observed across the different time points.ConclusionsHorizontal TAO strabismus correction leads to significant improvements of deviation angle and diplopia, with a stable undercorrection overtime. Inferior rectus recession leads to more unstable results, with a trend towards overcorrection limited to the first 6 months after surgery.
Thin endometrium is associated with higher risks of preterm birth and low birth weight after frozen single blastocyst transfer
Authors: Zheng Yu , Chen Biao , Dai Jun , Xu Bei , Ai Jihui , Jin Lei , Dong Xiyuan 
Published: November 2022

BackgroundIt has been demonstrated that a thin endometrium is associated with a lower chance of pregnancy, but there is a paucity of research into whether a thin endometrium adversely affects perinatal outcomes.MethodsThis was a retrospective cohort study on 10098 frozen cycles with single blastocyst transfer, resulting in 5505 singleton clinical pregnancies, and 4314 singleton live births. Patients were divided into a thin endometrium group (&lt;8 mm) and a normal endometrium group (≥8 mm). Multivariable logistic regression with restricted cubic splines, receiver operating characteristic curve, and multivariable linear model were used for statistical analysis.ResultsThe incidences of preterm birth (15.65 vs. 9.80%, aOR=1.69 [1.19-2.42]), low birth weight (8.40 vs. 4.10%, aOR=2.05 [1.27-3.30]) and gestational diabetes (6.87 vs. 4.17%, aOR=1.74 [1.05-2.90]) were all higher in the endometrial thickness (EMT) &lt;8 mm group. The miscarriage rate was higher in the EMT &lt;8 mm group than the EMT ≥8 mm group (27.91 vs. 20.39%, aOR=1.40 [1.10-1.79]).ConclusionA thin endometrium may be associated with a higher incidence of preterm birth, low birth weight, and miscarriage. Therefore, embryo transfer should be performed with caution in these patients, and postponing to a later cycle with a thicker endometrium should be considered.
An investigation into biochar, acid-modified biochar, and wood vinegar on the remediation of saline−alkali soil and the growth of strawberries
Authors: Pan Xin , Shi Mei , Chen Xichao , Kuang Shaoping , Ullah Habib , Lu Hongxiu , Riaz Luqman 
Published: November 2022

The salinization of several hundred million hectares of land poses a serious threat to global food security and biodiversity. Biochar and wood vinegar amendment has been suggested as a possible way to promote plant productivity and improve soil qualities, whereas less emphasis has been placed on the application of biochar in saline−alkaline soils to increase plant productivity. Herein, the single and composite application of sawdust biochar, wood vinegar, and acid-modified biochar on the restoration of coastal saline−alkali soil and plant growth of strawberry seedlings was investigated. Proximate and ultimate analyses and different characterization techniques such as FTIR and scanning electron microscopy were applied to study the physicochemical characteristics of raw and modified biochar. A pot experiment was conducted to explore the effects of different soil additives on soil properties and strawberry growth. Our results revealed that acid-modified biochar shows the most significant promoting effect on strawberry growth, which could increase the weight gain rate, root length, root specific surface area, and root volume of strawberry seedlings by 41.2%, 18.9%, 23.0%, and 34.7%, respectively. Moreover, the application of acid-modified biochar can effectively alleviate soil salinization by reducing soil pH (7.65) and CEC (19.5 cmol/kg). Furthermore, the addition of biochar can significantly improve the community structure of microorganisms (Proteobacteria) and increase the content of bacteria related to soil nutrient cycling (Pseudomonadaceae and Sphingomonadaceae). Preliminary findings from this study suggested that acid-modified biochar is a potentially effective means of preventing soil salinization and increasing economic crop yields.
Targeted metabolomics reveals fatty acid abundance adjustments as playing a crucial role in drought-stress response and post-drought recovery in wheat
Authors: Ullah Safi , Khan Mudassar Nawaz , Lodhi Sumaira Salahuddin , Ahmed Iftikhar , Tayyab Muhammad , Mehmood Tariq , Din Israr Ud , Khan Majid , Sohail Quahir , Akram Muhammad 
Published: November 2022

Drought stress is one of the abiotic stresses restricting plant development, reproductive growth, and survival. In the present study, the effect of drought stress and post-drought recovery for the selected local wheat cultivar, Atta Habib, was studied. Wheat was grown for 16 days followed by drought stress for 7 days and allowed to recover for 7 days after the removal of the drought stress. Same-aged untreated plants were also grown as a control. The effect of drought stress and post-drought recovery on morphology (root length, shoot length, root weight, and shoot weight), enzymatic activity, and fatty acid profile were analyzed. The results showed that shoot weight (93.1 mg), root weight (85.2 mg), and shoot length (11.1 cm) decreased in the stressed plants but increased steadily in the recovered plants compared to the same-aged control plants, while root length showed a higher increase (14.0 cm) during drought stress and tended to normalize during the recovery phase (13.4 cm). The ascorbate peroxidase activity increased in the stressed plants (5.44 unit/mg protein) compared to the control, while gradually normalizing in the recovery phase (5.41 unit/mg protein). Gas chromatography coupled mass spectrometric analysis revealed abundance changes in important fatty acids, such as palmitic acid, stearic acid, oleic acid, linoleic acid, and linolenic acid. Palmitic acid (39.1%) and oleic acid (2.11%) increased in the drought-stressed plants, while a reduction in linoleic acid (6.85%) and linolenic acid (51.18%) was observed compared to the same-aged control plants, i.e., palmitic (33.71%), oleic (0.95%), linoleic (7.52%), and linolenic acid (55.23%). The results suggest that wheat tries to recover in the post-drought stage by repairing oxidative damage through ascorbate peroxidase, and by adjusting fatty acid abundances under drought stress and during the post-drought phase in an effort to maintain membranes’ integrity and a suitable fat metabolism route, thus helping recovery. Targeted metabolomics may be further used to explore the role of other metabolites in the drought-stress response mechanism in wheat. Furthermore, this relatively little explored avenue of post-drought recovery needs more detailed studies involving multiple stress durations.
Analysis of signature genes and association with immune cells infiltration in pediatric septic shock
Authors: Fan Jiajie , Shi Shanshan , Qiu Yunxiang , Liu Mingnan , Shu Qiang 
Published: November 2022

BackgroundEarly diagnosis of septic shock in children is critical for prognosis. This study committed to investigate the signature genes and their connection with immune cells in pediatric septic shock.MethodsWe screened a dataset of children with septic shock from the GEO database and analyzed differentially expressed genes (DEGs). Functional enrichment analysis was performed for these DEGs. Weighted gene co-expression network analysis (WCGNA) was used to screen the key modules. Least absolute shrinkage and selection operator (LASSO) and random forest analysis were finally applied to identify the signature genes. Then gene set enrichment analysis (GSEA) was exerted to explore the signaling pathways related to the hub genes. And the immune cells infiltration was subsequently classified via using CIBERSORT.ResultsA total of 534 DEGs were screened from GSE26440. The data then was clustered into 17 modules via WGCNA, which MEgrey module was significantly related to pediatric septic shock (cor=−0.62, p&lt;0.0001). LASSO and random forest algorithms were applied to select the signature genes, containing UPP1, S100A9, KIF1B, S100A12, SLC26A8. The receiver operating characteristic curve (ROC) of these signature genes was 0.965, 0.977, 0.984, 0.991 and 0.989, respectively, which were verified in the external dataset from GSE13904. GSEA analysis showed these signature genes involve in positively correlated fructose and mannose metabolism and starch and sucrose metabolism signaling pathway. CIBERSORT suggested these signature genes may participate in immune cells infiltration.ConclusionUPP1, S100A9, KIF1B, S100A12, SLC26A8 emerge remarkable diagnostic performance in pediatric septic shock and involved in immune cells infiltration.
Overlapping-calibration of wide-swath altimeter baseline errors using two satellites formation flying design
Authors: Ma Chunyong , Wang Xuan , Gao Zhanwen , Li Zheng , Zhao Chaofang , Chen Ge 
Published: November 2022

The sea surface height (SSH) measured by future wide-swath altimetry satellites contains observation error due to baseline measurement, which is called SSH_Error_Baseline. It is a huge challenge for satellite engineering to maintain such high accuracies of the baseline roll and length in orbit to ensure that the SSH_Error_Baseline can be maintained below 1 cm. Therefore, how to effectively reduce the SSH_Error_Baseline is extremely important. In order to solve the existing problem, an innovative overlapping-calibration method is proposed based on two-satellite formation flight design with overlapping swath. In this study, the differences of SSH data observed by these two satellites in the overlapping area is so small that it can be ignored, and the SSH_Error_Baseline dominates the difference. Then, the baseline parameters of the two satellites can be well estimated by adopting an optimal inverse method. A total of 9 groups of observing system simulation experiments (OSSEs) have been carried out, and they respectively indicate different pessimistic theoretical scenarios of baseline measurement systems. According to the results, this design can effectively reduce the SSH_Error_Baseline in most scenarios. Regarding the advantage of this method, it can be applied to all along-track observation data without requiring the application of additional auxiliary data (i.e. model data, SSH derived from nadir altimetry). Therefore, when two wide-swath altimetry satellites are simultaneously designed, the formation flight scheme proposed in this paper is recommended, especially when the measurements of the baseline cannot meet the expected accuracies.
The effect of environmental factors on spatial-temporal variation of heterobranch sea slug community in northern Taiwan
Authors: Chan Ho Yeung , Chang Yen-Wei , Chen Li-Shu , Nishida Kazuki , Shao Yi Ta 
Published: November 2022

Sea slug (Subclass Heterobranchia) biodiversity is an important element of marine coral reef communities. However, due to their small size and cryptic behavior, few studies have examined their spatiotemporal variation. Taiwan is in the middle of East Asia Island Arcs, where it is one of the hotspots of sea slug diversity. Meanwhile, the northeast coast of this island lies within the subtropical monsoon region, where the climate shifts from a warm southwest monsoon (SW: May to Sep) to a cold northeast monsoon (NE: Oct to Apr). Between the monsoons, distinct temperatures and currents result in different community structures. To understand how those environmental factors (i.e., monsoon season, diel period and water depth) influence sea slug species richness and assemblages, we surveyed these invertebrates monthly at both night and day by diving in a marine protection area (CJ) and at a nearby non-protected site (MR) from May 2020 to Apr 2021. We showed that the species composition in our sampling area was highly consistent with what was found in Okinawa and Pescadores island, but less similar to those in southern Taiwan or Hong Kong. On the northeast coast of Taiwan, sea slug number and abundance were both higher in CJ than MR, but biodiversity (H’) and the species evenness indexJ’ was lower in CJ than MR. Additionally, cluster analysis indicated that the sea slug assemblages differed between the two sites. Monsoon season significantly influenced both species richness and species assemblages, with species richness during SW being significantly higher than in the NE monsoon and species assemblages also being distinct between these two seasons. Moreover, species richness increased with water depth (within the surveyed range of 0-25 m). Diel period did not exert a strong impact on sea slug biodiversity, except for species richness at CJ, where it was higher during the day than at night. Our study suggested that changing currents between the monsoon seasons could transport individuals originating from either the north or south of these island arcs. Furthermore, temperature and food sources may differ between seasons and depths, thereby influencing sea slug assemblages in this region.
Isotopic components and source analysis of inorganic nitrogen in coastal aerosols of the Yellow Sea
Authors: Zhang Ke , Liu Sumei , Wu Nian , Xu Wenqi 
Published: November 2022

The coastal atmospheric environment is one of the most complex environments on earth. It is shaped by terrestrial, marine, and atmospheric processes and acts as an external nutrient source for coastal waters. At present, there are few observations of inorganic nitrogen isotopes of China coastal aerosols, let alone the Yellow Sea. In this study, a weekly collection of total suspended particulate aerosols was conducted on the Qianliyan Island in 2018 for the measurements of inorganic nitrogen species (NO3− and NH4+) and their isotopic ratios (δ15N-NO3−, δ18O-NO3−, and δ15N-NH4+). At the Qianliyan Island, the average NO3− and NH4+ concentrations were 2.49 ± 2.12 and 3.33 ± 2.68 μg·m−3, respectively; the average δ15N-NO3−, δ18O-NO3−, and δ15N-NH4+ were 2.4‰ ± 5.7‰, 78.7‰ ± 8.0‰, and −2.6‰ ± 6.3‰, respectively. The major nitrate formation pathways were •OH oxidation and N2O5 hydrolysis paths, and the dominant sources of inorganic nitrogen aerosols were coal combustion (29% ± 7%), marine (19% ± 15%), and fertilizer (16% ± 13%). Aerosol δ15N-NO3− and δ18O-NO3− were obviously higher in winter and lower in summer; conversely, aerosol δ15N-NH4+ was slightly higher in summer and slightly lower in winter. The difference in nitrogen sources was considered to be the best explanation for the aerosol δ15N-NO3− and δ15N-NH4+ differences between summer and winter, of which coal combustion contributed the most. The seasonal difference in nitrate formation paths was considered to be the best explanation for the difference of Qianliyan aerosol nitrate δ18O-NO3− between summer and winter. Aerosol inorganic nitrogen deposition flux was estimated to be 3.4 nmol N·m−2·s−1, which induced less than 1% to marine primary production, and aerosol inorganic nitrogen deposition, compared with N2 fixation, contributed some 80% of δ15N-NO3− depression of the summer Yellow Sea thermocline.