bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep problems in rheumatoid arthritis over 12 years from diagnosis: results from the Swedish EIRA study
Authors: Lyne Lauren , Åkerstedt Torbjörn , Alfredsson Lars , Lehtonen Tiina , Saevarsdottir Saedis , Klareskog Lars , Westerlind Helga 
Published: January 2022

ObjectiveMost studies of rheumatoid arthritis (RA) and sleep have focused on established RA. We here investigate sleep quality and sleep duration in patients with newly diagnosed RA and during 1–12 years after diagnosis.MethodsData were collected on sleep 1–12 years after diagnosis from patients diagnosed 1998–2018 in the Swedish study Epidemiological Investigation of RA. Six sleep domains (sleep problems, non-restorative sleep, insomnia, insufficient sleep, sleep quality perceived as poor and sleep considered a health problem); a global sleep score and time spent in bed were estimated. Using logistic regression, ORs were calculated for each sleep outcome by disease duration. We explored whether pain (low (Visual Analogue Scale=0–20 mm, reference), intermediate=21–70, high=71–100) or functional impairment (Health Assessment Questionnaire>1.0) was associated with problems.ResultsWe had sleep data on 4131 observations (n=3265 individuals). Problems with ≥1 sleep domain (global sleep score) was reported in 1578 observations (38%) and increased with disease duration (OR 1.04, 95% CI 1.02 to 1.07). Median time in bed was 8 hours (Q1-Q3: 7.5–9.0). High-grade pain increased the likelihood of sleep problems ~3–9 fold, and increased functional impairment ~4–8 fold.ConclusionIn this cohort of newly diagnosed patients with RA with access to the current treatment from diagnosis, we did not find any major problems with sleep, and existing sleep problems related mainly to pain and reduced function. Treatment of sleep problems in RA should be guided towards treating the underlying problem causing the sleep disturbance.
Immunogenicity of BNT162b2 mRNA SARS-CoV-2 vaccine in patients with psoriatic arthritis on TNF inhibitors
Authors: Venerito Vincenzo , Stefanizzi Pasquale , Fornaro Marco , Cacciapaglia Fabio , Tafuri Silvio , Perniola Simone , Iannone Florenzo , Lopalco Giuseppe 
Published: January 2022

BackgroundScanty data on the immunogenicity of the BNT162b2 vaccine in patients with psoriatic arthritis (PsA) on Tumor Necrosis Factor inhibitors (TNFi) have been published.ObjectiveTo investigate the humoral response to BNT162b2 vaccination patients with PsA on TNFi, comparing immunogenicity with healthy controls.MethodsForty patients with classified PsA on TNFi undergoing vaccination with the BNT162b2 mRNA SARS-CoV-2 vaccine (BioNTech/Pfizer) were enrolled. Fifteen days after the second shot, serum IgG levels against SARS-CoV-2 (Abbott ARCHITECT i2000SR, positivity cut-off 50 AU/mL) were assayed in all patients. Clinimetrics and treatment data were gathered. TNFi treatment was not discontinued throughout the whole period, whereas methotrexate (MTX) was discontinued for 1 week after each shot in those on combination therapy. Sera from healthcare professionals were considered as healthy controls for 1:1 propensity score matching; any of them was taking medication.Student’s t-test and logistic regression were used for investigating differences in immunogenicity between groups and predictors of antibody response.ResultsClinical Disease Activity Index did not change before and after vaccination (7.06±5.23 to 7.10±5.27, p=0.92).Patients with PsA achieved a positive anti-SARS-CoV-2 IgG level with a mean (±SD) of 13794.44±15 815.42 AU/mL. Although lower, the antibody level was not significantly different from matched controls (19227.4±11.8460.45 AU/mL, p=0.08). In the overall sample, those on MTX (12/80, 15%) had a trend toward lower immune response (p=0.07); glucocorticoid therapy (11/80, 13.8%) predicted lower antibody levels (p=0.04).ConclusionsContinuing TNFi in patients with PsA throughout the vaccination did not hamper immunogenicity.
Immune responses to mRNA vaccines against SARS-CoV-2 in patients with immune-mediated inflammatory rheumatic diseases
Authors: Sieiro Santos Cristiana , Calleja Antolin Sara , Moriano Morales Clara , Garcia Herrero Juan , Diez Alvarez Elvira , Ramos Ortega Fernando , Ruiz de Morales Jose G 
Published: January 2022

BackgroundPatients with immune-mediated rheumatic diseases (IMRDs) are commonly treated with immunosuppressors and prone to infections. Recently introduced mRNA SARS-CoV-2 vaccines have demonstrated extraordinary efficacy across all ages. Immunosuppressed patients were excluded from phase III trials with SARS-CoV-2 mRNA vaccines.AimsTo fully characterise B-cell and T-cell immune responses elicited by mRNA SARS-CoV-2 vaccines in patients with rheumatic diseases under immunotherapies, and to identify which drugs reduce vaccine’s immunogenicity.MethodsHumoral, CD4 and CD8 immune responses were investigated in 100 naïve patients with SARS-CoV-2 with selected rheumatic diseases under immunosuppression after a two-dose regimen of SARS-CoV-2 mRNA vaccine. Responses were compared with age, gender and disease-matched patients with IMRD not receiving immunosuppressors and with healthy controls.ResultsPatients with IMRD showed decreased seroconversion rates (80% vs 100%, p=0.03) and cellular immune responses (75% vs 100%, p=0.02). Patients on methotrexate achieved seroconversion in 62% of cases and cellular responses in 80% of cases. Abatacept decreased humoral and cellular responses. Rituximab (31% responders) and belimumab (50% responders) showed impaired humoral responses, but cellular responses were often preserved. Antibody titres were reduced with mycophenolate and azathioprine but preserved with leflunomide and anticytokines.ConclusionsPatients with IMRD exhibit impaired SARS-CoV-2 vaccine immunogenicity, variably reduced with immunosuppressors. Among commonly used therapies, abatacept and B-cell depleting therapies show deleterious effects, while anticytokines preserved immunogenicity. The effects of cumulative methotrexate and glucocorticoid doses on immunogenicity should be considered. Humoral and cellular responses are weakly correlated, but CD4 and CD8 tightly correlate. Seroconversion alone might not reflect the vaccine’s immunogenicity.
Vessel inflammation and morphological changes in patients with large vessel vasculitis: a retrospective study
Authors: Besutti Giulia , Muratore Francesco , Mancuso Pamela , Ferrari Marco , Galli Elena , Spaggiari Lucia , Monelli Filippo , Casali Massimiliano , Versari Annibale , Boiardi Luigi , Marvisi Chiara , Ligabue Guido , Pattacini Pierpaolo , Giorgi Rossi Paolo , Salvarani Carlo 
Published: January 2022

ObjectiveThe aim was to identify any association between imaging signs of vessel wall inflammation (positron emission tomography–CT (PET-CT) score and CT/MR wall thickening) and synchronous and subsequent vascular damage (stenoses/dilations) in patients with large vessel vasculitis (LVV).MethodsConsecutive patients with LVV referred to a tertiary centre in 2007–2020 with baseline PET-CT and morphological imaging (CT/MR angiography) performed within 3 months were included. All available PET-CT and CT/MR scans were reviewed to assess PET-CT uptake (4-point semi-quantitative score), wall thickening, stenoses and dilations for 15 vascular segments. The associations of baseline PET score and CT/MR wall thickening with synchronous and incident stenoses/dilations at CT/MR performed 6–30 months from baseline were evaluated in per-segment and per-patient analyses. Respective areas under the receiver operating characteristic curve (AUC) were calculated.ResultsWe included 100 patients with LVV (median age: 48 years, 22% males). Baseline PET score and wall thickening were strongly associated (Cuzick non-parametric test for trend across order groups (NPtrend) <0.001). The association with synchronous stenoses/dilations was weak for PET score (NPtrend=0.01) and strong for wall thickening (p<0.001). In per-patient analyses, sensitivity/specificity for ≥1 synchronous stenoses/dilations were 44%/67% for PET score ≥2 and 66.7%/60.5% for wall thickening. Subsequent CTs/MRs were available in 28 patients, with seven incident stenoses/dilations. Baseline PET score was strongly associated with incident stenoses/dilations (p=0.001), while baseline wall thickening was not (p=0.708), with AUCs for incident stenoses/dilations of 0.80 for PET score and 0.52 for wall thickening.ConclusionPET score and wall thickening are strongly associated, but only baseline PET score is a good predictor of incident vessel wall damage in LVV.
The Roles of RNA Helicases in DNA Damage Repair and Tumorigenesis Reveal Precision Therapeutic Strategies
Authors: Xie Jinru , Wen Ming , Zhang Jiao , Wang Zheng , Wang Meng , Qiu Yanfang , Zhao Wenchao , Zhu Fang , Yao Mianfeng , Rong Zhuoxian , Hu Wenfeng , Pei Qian , Sun Xiaoxiang , Li Jinchen , Mao Zhiyong , Sun Lun-Quan , Tan Rong 
Published: January 2022

Abstract

DEAD-box RNA helicases belong to a large group of RNA-processing factors and play vital roles unwinding RNA helices and in ribosomal RNA biogenesis. Emerging evidence indicates that RNA helicases are associated with genome stability, yet the mechanisms behind this association remain poorly understood. In this study, we performed a comprehensive analysis of RNA helicases using multiplatform proteogenomic databases. More than 50% (28/49) of detected RNA helicases were highly expressed in multiple tumor tissues, and more than 60% (17/28) of tumor-associated members were directly involved in DNA damage repair (DDR). Analysis of repair dynamics revealed that these RNA helicases are engaged in an extensively broad range of DDR pathways. Among these factors is DDX21, which was prominently upregulated in colorectal cancer. The high expression of DDX21 gave rise to frequent chromosome exchange and increased genome fragmentation. Mechanistically, aberrantly high expression of DDX21 triggered inappropriate repair processes by delaying homologous recombination repair and increasing replication stress, leading to genome instability and tumorigenesis. Treatment with distinct chemotherapeutic drugs caused higher lethality to cancer cells with genome fragility induced by DDX21, providing a perspective for treatment of tumors with high DDX21 expression. This study revealed the role of RNA helicases in DNA damage and their associations with cancer, which could expand therapeutic strategies and improve precision treatments for cancer patients with high expression of RNA helicases.

Significance:
The involvement of the majority of tumor-associated RNA helicases in the DNA damage repair process suggests a new mechanism of tumorigenesis and offers potential alternative therapeutic strategies for cancer.
Impact of Hypertensive Disorders of Pregnancy on the Risk of Stroke Stratified by Subtypes and Follow-Up Time
Authors: Hung Shih-Kai , Lee Moon-Sing , Lin Hon-Yi , Chen Liang-Cheng , Chuang Chi-Jou , Chew Chia-Hui , Yu Ben-Hui , Yang Hsuan-Ju , Hsu Feng-Chun , Chiou Wen-Yen 
Published: January 2022

Background and Purpose:
Hypertensive disorders of pregnancy (HDP) comprise 4 subtypes. Previous studies have not investigated the relationship between stroke risk, different HDP subtypes, and follow-up time, which was the purpose of this study.

Methods:
Data of 17 588 women aged 18 to 45 years who had a history of HDP in Taiwan from 2000 to 2017 was retrospectively reviewed. After matching with confounders, 13 617 HDP women and 54 468 non-HDP women were recruited.

Results:

HDP women had an adjusted hazard ratio (aHR) of 1.71 (95% CI, 1.46−2.00) for stroke, and 1.60 (1.35−1.89) and 2.98 (2.13−4.18) for ischemic and hemorrhagic stroke, respectively (
P
<0.001 for all). The overall stroke risk in the HDP group was still 2.04 times 10 to 15 years after childbirth (1.47−2.83,
P
<0.001). Although the risks of both ischemic and hemorrhagic stroke persisted, their risk time trends were different. The risk of ischemic stroke reached peak during 1 to 3 years after childbirth with an aHR of 2.14 (1.36–3.38), while hemorrhagic stroke risk gradually increased and had an aHR of 4.64 (2.47−8.73) after 10 to 15 years of childbirth (both
P
<0.001). Among the 4 HDP subtypes, chronic hypertension with superimposed preeclampsia had the highest stroke risk (aHR=3.86, 1.91−7.82,
P
<0.001), followed by preeclampsia–eclampsia (aHR=2.00, 1.63−2.45,
P
<0.001), and gestational hypertension (aHR=1.68, 1.13−2.52,
P
<0.05); chronic preexisting hypertension had the lowest stroke risk (aHR=1.27, 0.97−1.68,
P
>0.05). Furthermore, multiple HDP combined with preeclampsia had aHR of 5.48 (1.14−26.42,
P
<0.05).

Conclusions:
The effect of HDP on the risk of future stroke persisted for up to 17 years, both for ischemic and hemorrhagic strokes. The presence of multiple HDP and preeclampsia further increase the stroke risk.
The Power of the Written Word in Manichaeism
Authors: Moiseeva Evgenia 
Published: January 2022

Abstract
The prominent role books and the act of writing played in the life of the Manichaean Church distinguishes Manichaeism even among other “religions of the book.” This article tackles the question whether the primacy of writing was established by Mani himself or resulted from a development that occurred within the first generations of Mani’s followers. The analysis of the extant fragments of Mani’s own works and early Manichaean texts such as the work of Baraies preserved in the Cologne Mani Codex and the Kephalaia indicate that Mani’s superiority as a writing prophet and the ritual meaning of writing most likely were not part of Mani’s original teaching. Rather, they resulted from the efforts of Manichaean theologians who sought to demonstrate the exceptional status of Mani’s revelation and prophetic mission based on his writings. The Prologue to the Kephalaia of the Teacher played a significant role in this development and contributed extensively to the ritualization of writing in Manichaeism.
Constitutio in actu? Eliezer Dileon’s Letter to the Minsk Kahal, 1817
Authors: Guesnet François 
Published: January 2022

Abstract
A letter by the army contractor Eliezer Dileon to the community board of Minsk relating his audience with Tsar Alexander I of Russia in January 1817 sheds light on the significance of the performative dimension of Jewish intercession. In the perception of the intercessor, due to the personal encounter between the sovereign ruler and himself, the Jews in Russia constitute part of the political and societal fabric of the Empire, it sees them as ‘a people.’ The letter is one of the very few documents describing and confirming the symbolic meaning of an encounter between a monarch and a Jewish intercessor. It reflects on the reciprocal nature of negotiations between the state and the Jewish minority, the limitations in concrete outcomes notwithstanding.
Mucosal Bridge Reconstruction: A Novel Approach for the Vocal Fold Mucosal Bridge
Authors: Başer Engin , Denizoğlu İsmail İlter 
Published: January 2022

Introduction: Mucosal Bridges (MBs) are defined as benign connective tissue abnormalities of unclear etiology that extend over the free surface of the vocal fold, are attached to the front and back of the vocal fold but are not attached to its free surface, and are histologically covered by stratified squamous epithelium. In order to overcome these drawbacks, we aimed to retrospectively evaluate and present the preoperative and postoperative results of patients with MB, who were applied the method we call “Mucosal Bridge Reconstruction” (MBR), which we apply as suturing rather than resection of the MB. Methods: Between January 2016 and February 2020, 5 patients who applied to the voice clinic due to dysphonia and were diagnosed with MB via laryngostroboscopic examination and direct laryngoscopy under general anesthesia were included in the study. Dr Speech software was used for acoustic analysis; mean fundamental frequency (fo), jitter %, shimmer %, and noise to harmonic ratio (NHR) were objectively measured and recorded. Voice Handicap Index-10 (VHI-10) was used for positive self-reporting of the severity of vocal symptoms. GRBAS scale (G: Grade, R: Roughness, B: Breathiness, A: Asthenia, and S: Strain) was also used (by the same clinician) for clinic subjective evaluation. Results: Patient age ranged from 33 to 55 years and mean patient age was 42 years. Mean duration of symptoms was 22 months (range 16-30). Mean postoperative follow-up time was 14 months (range 6-24). Unilateral MB was observed in all patients (2 left, 3 right). There was a significant improvement in objective and subjective assessment methods in all our patients after surgery. Conclusions: According to the results of our few patients, MBR offers a physiological and anatomical approach to the treatment of patients with MB. The outcomes of delicate microlaryngeal surgery are promising.
Declining Women Work Participation in Rural India: Trends, Causes and Policy Implications
Authors: Mamgain Rajendra P. , Khan Khalid 
Published: January 2022

One of the major policy concerns in recent years has been decline in the number of women workers in the Indian labour market. The ‘education’ and ‘income’ effect hypotheses for such decline are generally advocated. Such analyses, however, are limited in their focus. This study attempts to fill up this gap by exclusively focusing on rural women. Using the National Sample Survey Organisation (NSSO) data for the years 2004–2005 and 2011–2012 and Periodic Labour Force Survey data for the year 2017–2018, it observes a widespread decline in rural women’s work participation rates (WPRs) across their different social groups, income strata and states in the country albeit at a significantly varying rate. While the major decline in women WPRs in the age-group, 15–24 years has been in favour of education, it has been largely in favour of ‘domestic works’ in the other age-groups. The major decline in women workforce is observed in case of those as not-literates, ‘unpaid family labour’ in agriculture and ‘casual wage labour’ both in farm and non-farm sectors. This is largely due to contraction in self-employment and casual wage works both in farm and non-farm sectors, more so during recent period. This study finds a positive impact of rising household income on women’s WPRs. While education emerges as a significant predictor of women joining workforce, its iteration with their social groups shows differing impact of similar level of education on different caste groups. It offers inputs for policy measures to be aimed at providing decent livelihoods in rural areas in a big scale, with strong focus on reducing caste and gender disparities. JEL Codes: E24, J16, J21, J18
Gender, Life Domains, and Intimate Partner Violence Perpetration: A Partial Test of Agnew’s General Theory of Crime and Delinquency
Authors: Ngo Fawn T. , Zavala Egbert , Piquero Alex R. 
Published: January 2022

Objectives We assess the proposed mechanisms outlined in Agnew’s General Theory of Crime and Delinquency about gender differences in crime and deviance (gender differences are due to differences between males and females in their standing on the life domains or differences in the effect of the life domains on the phenomenon among males and females) in accounting for sex differences in intimate partner violence (IPV) among a sample of young adults. Methods Drawing data from the International Dating Violence Study (IDVS) and employing the negative binomial regression method, we examined the effects of six self-domains, four family domains, one school/work domain, and one peer domain measures on IPV. Results Although males reported a higher frequency across all five life domains compared to females, the number of life domain variables that were significantly related to IPV among females was greater than the number among males. Further, the effects of the life domain variables on IPV were different for males and females with the peer variable (criminal peers) exhibiting the greatest effect on IPV among males and the self-domain (anger issues) demonstrating the greatest effect on IPV among females. Conclusions Agnew’s theory is well suited to assess sex differences in IPV.
Self-Esteem Moderates the Relationship Between Secure Attachment and Internalizing and Externalizing Problems in Preadolescence
Authors: Irvine Taylor J. , Aults Christopher D. , Menon Meenakshi 
Published: January 2022

This longitudinal study examined the interactive effects of secure attachment and self-esteem on change in internalizing and externalizing problems in a sample of preadolescents. 407 youth ( Mage = 11.1 years) completed measures of self-esteem, secure attachment style, and peer nomination inventories tapping internalizing and externalizing problems at the beginning of the fourth and fifth grades. Results suggest that internalizing and externalizing problems may be reduced for securely attached youth with high self-esteem. Implications for future research are examined, along with a discussion on clinical applications of studies involving interaction effects.
Premature rejection in science: The case of the Younger Dryas Impact Hypothesis
Authors: Powell James Lawrence 
Published: January 2022

The progress of science has sometimes been unjustifiably delayed by the premature rejection of a hypothesis for which substantial evidence existed and which later achieved consensus. Continental drift, meteorite impact cratering, and anthropogenic global warming are examples from the first half of the twentieth century. This article presents evidence that the Younger Dryas Impact Hypothesis (YDIH) is a twenty-first century case. The hypothesis proposes that the airburst or impact of a comet ∼12,850 years ago caused the ensuing ∼1200-year-long Younger Dryas (YD) cool period and contributed to the extinction of the Pleistocene megafauna in the Western Hemisphere and the disappearance of the Clovis Paleo-Indian culture. Soon after publication, a few scientists reported that they were unable to replicate the critical evidence and the scientific community at large came to reject the hypothesis. By today, however, many independent studies have reproduced that evidence at dozens of YD sites. This article examines why scientists so readily accepted the early false claims of irreproducibility and what lessons the premature rejection of the YDIH holds for science.
Childhood Disadvantage and Adult Functional Status: Do Early-Life Exposures Jeopardize Healthy Aging?
Authors: Morton Patricia M. 
Published: January 2022

Objectives To examine whether childhood disadvantage is associated with later-life functional status and identify mediating factors. Methods Unique and additive effects of five childhood domains on functional status were assessed at baseline (2006) and over time (2006–2016) in a sample of 13,894 adults from the Health and Retirement Study (>50 years). Adult health behaviors and socioeconomic status (SES) were tested as mediators. Results Respondents exposed to multiple childhood disadvantages (OR = .694) as well as low childhood SES (OR = .615), chronic diseases (OR = .694), impairments (OR = .599), and risky adolescent behaviors (OR = .608) were less likely to be free of functional disability by baseline. Over time, these unique and additive effects of childhood disadvantage increased the hazard odds of eventually developing functional disability (e.g., additive effect: hOR = 1.261). Adult health behaviors and SES mediated some of these effects. Discussion Given the enduring effects of childhood disadvantage, policies to promote healthy aging should reduce exposure to childhood disadvantage.