bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxychloroquine ameliorates DSS-induced colitis by inhibiting M1 macrophage polarization through NF-κB/NLRP3 signaling pathway
Authors: jiang jingyue , Wang Di , Wang Shu , Ye Ziping , Mao Xiaqiong , Zhao XiaoJing , Zhang Hongjie 
Published: October 2022

Abstract
Background and Aims: Polarization of macrophages to the M1 or M2 phenotype is critical for the development and occurrence of inflammation and disease. An increased proportion of M1-type macrophages has been observed in inflammatory bowel disease (IBD). Macrophage-targeted hydroxychloroquine (HCQ) nanotherapeutics are highly effective treatments for autoimmune diseases. HCQ has been widely used in the treatment of autoimmune diseases because of its anti-inflammatory and immunomodulatory properties. We investigated the potential effect of HCQ on dextran sulphate sodium salt (DSS)-induced colitis as well as the underlying potential mechanism.
Methods: C57BL/6 mice were randomly divided into three groups: control, DSS, or DSS + HCQ. The mRNA expressions of cytokines in M1 macrophages were measured using quantitative RT-PCR. The proportion of F4/80+CD86+ (M1) macrophages was measured by flow cytometry. Bone marrow-derived macrophages (BMDMs) were isolated and stimulated with LPS/IFN-γ to induce M1 macrophages. The levels of NF-κB p65, phospho-p65, NLRP3, ASC, and caspase-1 in the macrophages were detected by western blotting.
Results: HCQ ameliorates DSS-induced colitis as evidenced by improved colon shortening, reduced disease activity index (DAI), and decreased histopathological scores. Furthermore, HCQ decreased the expressions of M1-related cytokines and significantly decreased the percentage of F4/80+CD86+ (M1) subsets in colonic lamina propria cells in DSS-induced colitis mice. Moreover, HCQ significantly repressed M1 polarisation. HCQ can decrease the phosphorylation of NF-κB and the expressions of NLRP3, ASC, and caspase-1 in M1 macrophages. Blocking the NF-κB signaling pathway downregulated NLRP3 inflammasomes, and reduced the number of F4/80+CD86+ M1 macrophages.
Conclusions: HCQ attenuated colonic inflammation by inhibiting M1 macrophage polarization through the NF-κB/ NLRP3signaling pathway.
Correlation of the salivary cortisol levels in women with functional hypothalamic amenorrhea and healthy women: A pilot study.
Authors: Koukoubanis Konstantinos , Stefanaki Katerina , Kalampalikis Andreas , Michala Lina 
Published: October 2022

Abstract
Purpose: The aim of this study was to investigate the aberrations of cortisol secretion, measured by salivary cortisol in women with FHA.
Methods The study, an observational study, was performed in a gynecological outpatient clinic of a university hospital in Greece, between July 2019 and March 2021. The study included 12 (twelve) patients with diagnosed FHA and 12 (twelve) women of comparative demographics, with a normal menstrual cycle who were used as controls.
Results: 24 women were included in the study. Women with FHA had significantly higher levels of morning salivary cortisol (21.81 ± 5.63 nmol/l vs 12.76 ± 3.64 nmol/l; P <0.0001) when compared to normal controls. Measurements in the afternoon and midnight were not significantly different. There was a negative correlation between morning salivary cortisol levels and ΒΜΙ (rho: -0.53, p = 0.009), while there was a positive correlation between morning salivary cortisol levels and disordered eating habits (rho: 0.53, p = 0.00) and a positive correlation between morning salivary cortisol levels and reported stress levels (rho: 0.47, p = 0.02).
Conclusion: Cortisol levels were raised in women with FHA, suggesting increased stress levels. This was particularly obvious the measurement of salivary cortisol levels could be a promising research tool and be used as a potential biomarker of recovery of menses. In addition, it could be used as a tool for the management of the disease and follow-up of patients suffering from functional hypothalamic amenorrhea. Further studies should be conducted to indicate and clarify the specific salivary cortisol levels associated with the occurrence of the disease or recovery of menses.
Quantification of the ecophysiological advantages of mycorrhiza-maize symbiosis: A promising approach for sustainable food production systems
Authors: Jahan Mohsen , Nassiri-Mahallati Mehdi 
Published: October 2022

Abstract
Purpose
Plant-Soil – “Arbuscular Mycorrhizal Fungi (AMF)” system dynamics are driven by complex arrays of simultaneous cause-effect relationships. Understanding this complexity requires high sophisticated analytical tools and methods such as Structural Equation Modeling (SEM). There has been no practical solution to determine plant-fungus coexistence efficacy. Therefore, the objective of this study is to find a multidisciplinary method to determine the contribution of AMF in coexistence with maize plant.
Methods
Confirmatory factor analysis divided the variables into two groups. On the ecophysiological basis, SEM was employed to above- and belowground relationships in corn-mycorrhizae fields. A SEM model was formulated including the path for cause-effect processes of capture and utilization of resources. The model was satisfactorily calibrated and validated.
Results
Applying multiple regression revealed that variables including leaf area index, stem diameter, dry matter, SPAD readings, plant height, canopy temperature have had the most causal effect to forming corn yield under field condition of inoculation by AMF. RMSEA = 0.14 and normalized chi-square = 1.97 indicated the model competence. The direct advantages of AMF symbiosis make an increase of 35 percent in resources capture (radiation and from the soil) by association.
Conclusions
These results could be used to manage crop producing systems according to ecological guidelines and environmentally sound operations. We recommend SEM as a crop-soil-AMF system quantifying tool for analyzing treatment effects also for complex arrays of management objectives. The method can employ to determine the efficacy of crop-AMF coexistence which in turn reveal related advantageous may resulted in widespread applying AMF in agroecosystems.
Increasing phosphorus fertilizer value of recycled iron phosphates in strong P-fixing soils by prolonged flooding and organic matter addition
Authors: Saracanlao Rochelle Joie , Ryckel Hannah , Everaert Maarten , Verbeeck Mieke , Smolders Erik 
Published: October 2022

Abstract

Iron (Fe) minerals are commonly used to remove phosphorus (P) from waste streams, producing P-loaded Fe(III) oxides or Fe(II)P minerals (e.g. vivianite). These minerals may be used as fertilizers to enhance P circularity if solubilized in soil. Here, we tested the P fertilizer value of recycled iron phosphates (FePs) in a pot trial and in an incubation experiment, hypothesizing that P release from FePs is possible under Fe(III) reducing conditions. First, a pot trial was set up with rice (Oryza sativa) in all combinations of soil flooding or not, three P-deficient soils (acid, neutral, calcareous) and six FePs (three Fe(III) and three Fe(II)phosphates) referenced to triple superphosphate (TSP) or zero amendments. Shoot P uptake responded to TSP applications in all treatments but only marginally to FePs. The redox potential did not decrease below 200 mV by flooding for a brief period during the pot trial. A longer incubation experiment (60 days) was performed which included a treatment of glutamate addition to stimulate reductive conditions and P availability was assessed with CaCl2 extraction of soils. Glutamate addition and/or longer incubation lowered soil redox potential to <-100 mV. On the longer term, Fe(III) minerals released P and adequate P was reached in the calcareous soil and in the neutral soil amended with Fe(III)P-sludge. It can be concluded that prolonged soil flooding and organic matter (OM) addition can enhance the P fertilizer efficiency of FePs. Additional treatments showed that application of FeP in powder form may enhance P availability.
Early drain removal after live liver donor hepatectomy is safe - A randomized control trial
Authors: Durairaj Parthiban , Pamecha Viniyendra , Mohapatra Nihar , Patil Nilesh , Sindhwani Gaurav 
Published: October 2022

Abstract

INTRODUCTION: The aim of current study was to assess safety of early drain removal after live donor hepatectomy (LDH).
METHODS: 108 consecutive donors who met the inclusion criteria, were randomized to Early Drain Removal (EDR – post operative day (POD) 3 - if serous and the drain bilirubin level was less than 3 times of serum bilirubin - “3x3” rule) and Routine Drain Removal (RDR – drain output serous and less than 100ml). Primary outcome was to compare the safety. Secondary outcomes was to compare the post-operative morbidity.
RESULTS: Pre-operative, intra-operative and postoperative parameters except for timing of drain removal were comparable. EDR was feasible in 46 out of 54 donors (85.14%) and none required re-intervention after EDR. There was significantly better pain relief with EDR (p=0.00). Overall complications, pulmonary complications, and hospital stay were comparableon intention-to-treat analysis. However, pulmonary complications (EDR - 1.9% Vs RDR -16.3% P= 0.030), overall complications (18.8% Vs 36.3%, P= 0.043) and hospital stay (8 Vs 9, P= 0.014) were more in RDR group on per treatment analysis. Bile leaks were seen in three donors (3.7% in EDR group Vs RDR 1.9% in P=0.558), none of them required endobiliary interventions. Re-Exploration for intestinal obstruction was required for 3 donors in RDR (0% vs 5.7%; p-0.079).
CONCLUSION: EDR by “3x3” rule after LDH is safe and associated with significantly better pain relief. On per treatment analysis, EDR was associated with significantly less hospital stay, pulmonary and overall complications.
Clinical Trial Registry: Clinical Trials.gov - NCT04504487.
Heteroscedastic-embedded Ensemble for Imbalanced Massive Data Classification
Authors: Li Hong , Peng Ge , Wang Jia , Xu Xinggui , Qian Kun 
Published: October 2022

Abstract

The imbalanced learning methods aim to learn the unbiased models from massive class-imbalanced datasets. However, due to the uncertainty of data distributions affected by noise and borderline samples, the models based on heuristic assumptions or meta learning often suffer from the lack of stability and practicability for real-world classification tasks which often uses the skewed dataset of low-quality. In order to effectively cope with these issues, in this work, we propose a novel heteroscedastic-embedded ensemble (HEE) for imbalanced massive data classification. We first design an effective task sensing strategy with data-dependent heteroscedastic to adaptively guide the sampler’s focus on informative samples, which makes the learning method much more robust for noisy data. Then, similar to the learning style of human beings, i.e., easy to difficult, the HEE framework gradually builds a strong ensemble classifier through interactions between harmonizing data resampling and model-training. The simulation results and analysis on both synthetic and real-world tasks demonstrate the effectiveness, robustness, and transferability of the proposed method.
The clinical symptoms in post COVID condition among Syrian population
Authors: alshami Sara , mohammad Yousser 
Published: October 2022

Abstract
Background: Post-Covid case is a single condition that occurs in people with a confirmed or probable history of infection with the Coronavirus, usually three months after the onset of symptoms of infection with the Coronavirus, with symptoms persisting for at least two months, and that cannot be explained by an alternative diagnosis.
Following up on patients who have recovered from COVID-19 has shown that one or more symptoms persist in a significant proportion of people, even weeks or months after COVID-19. Newly onset symptoms may be following initial recovery from acute COVID-19 infection or persistent from acute COVID-19 infection. Symptoms may recur or regress over time.
Aim of the study: Since there are no previous studies on Post-Covid Syndrome in Syria, we conducted this study to evaluate clinical symptoms in Post-Covid Syndrome among Syrian population.
This will be the first study in Syria about post-Covid syndrome.
Method: We designed this observational cross-sectional study to collect self-reported information using an on-line questionnaire. We used a list of 18 possible symptoms, Fatigue Assessment Scale (FAS), the modified Medical Research Council (mMRC) dyspnea scale, cough symptom score (CSS) in the questionnaire to assess the symptoms in post COVID condition.
Result: We found that only 34.4% of our population have no symptoms while the others suffered from symptoms in context of post COVID condition. 25% did not suffer from any kind of fatigue. 55% experienced various degrees of dyspnea. 33% had different degrees of cough and 37% experienced various degrees of chest pain.
Conclusion: It is noted that the post-Covid condition is relatively widespread, which requires the attention of the health care system, as it constitutes a burden on the quality of life of individuals and a negative impact on society.
Continuous generation of single-copy MosTI insertions in C. elegans from a multiplex mix.
Authors: Mouridi Sonia El , Frøkjær-Jensen Christian 
Published: October 2022

Abstract

Precise expression of transgenes in C. elegans can be used to understand gene regulation, control cells, or as a starting point for genetic screens. Inserting single-copy transgenes into well-defined safe-harbor locations is useful when consistent expression levels are required (e.g., to compare expression from different transgenes) or when expression is desired in germ cells. Here, we describe a detailed protocol for the simultaneous injection of several different plasmids ("multiplex mix"). Heat-shock inducible Cas9 expression allows the insertion of single-copy transgenes from the multiplex mix using Modular Safe-harbor Transgene Insertion (MosTI). The protocol allows the generation of many different transgene inserts over several generations from a single injection. In principle, the method can be used to screen a collection of plasmids for a desirable property, such as expression in a particular tissue. Only a few extra-chromosomal strains are required, which makes the protocol particularly appropriate for researchers with limited experience with C. elegans micro-injection.
Stepwise efficiency assessment in a competitive scenario using DEA for ratios: service level benchmark
Authors: Gidion Dickson K. , Karia Adam O. , Nyangi Magori J. , Mwamila Tulinave B. , Senkondo William , Mmasi Doglas B. , Alphayo Stephano M. , Khoveyni Mohammad 
Published: October 2022

Abstract
Urban water utility (UWU) regulation has been a potential practice in the water industry for years. This is because UWUs operate in an environment without competitors, and regulating them in a competitive scenario under sunshine regulation helps UWUs simulate the best management strategies. During efficiency assessment, the selection of the best, intermediate and least performing UWUs involves averaging scores of many efficiency assessment criteria analysed separately. This study expands a UWU efficiency assessment based on attaining service-level-benchmark and agreed target-level criteria using network data envelopment analysis (NDEA) for ratios. The assessment shows that the average of efficiencies of the two criteria identify a UWU with the best and worst performance in selected key indicators.
Retracted: Synthesis characterization of Zn-based MOF and their application in degradation of water contaminants
Authors: Jasim Saade Abdalkareem , Amin Hawraz Ibrahim M. , Rajabizadeh Ahmad , Nobre Marcos Augusto Lima , Borhani Fariba , Jalil Abduladheem Turki , Saleh Marwan Mahmood , Kadhim Mustafa M. , Khatami Mehrdad 
Published: October 2022

AbstractWater Science & Technology issues a formal retraction in relation to the above article by Saade Abdalkareem Jasim et al. The publisher issues this retraction for the following reasons. Following publication, concerns were raised regarding potential citation manipulation in this article, due to a large number of inappropriate references. The journal did not receive a satisfactory response to these concerns and during the investigation additional concerns were raised about the authorship of the article, including the authors' contributions. The Editors-in-Chief therefore no longer have confidence in the reliability of the findings presented.
ANÁLISE VISUAL DO MOBILIÁRIO URBANO INFANTIL
Authors: Azevêdo Viviane , Veloso Isis 
Published: October 2022

Espaços livres qualificados que satisfazem as necessidades de seus usuários influenciam positivamente o bem-estar dos indivíduos e, a longo prazo, contribuem com a sua qualidade de vida. De maneira oposta, aqueles que não atendem às preferências de seus utilizadores afetam negativamente o comportamento humano, influindo para a não utilização destes, e tornando-os subutilizados. Nesse contexto, a pesquisa tem como objetivo investigar as relações de uso e apropriação dos usuários (crianças e seus acompanhantes) pelo espaço livre e mobiliário destinado ao público infantil de um parque urbano localizado na cidade de Campina Grande-PB. Para a compreensão desses elementos, o trabalho foi dividido em duas etapas, a primeira etapa corresponde à análise visual urbana através da aplicação das ferramentas de visão serial, mapa mental e mapa psicogeográfico. A segunda etapa corresponde à análise visual do design através de ferramentas de categorias funcionais, de comunicação e investigação. Os resultados da pesquisa apontam que apesar dos problemas identificados, relacionados ao déficit de mobiliários urbanos, interferência externa e interna de adultos, preferência por horários, composição visual desordenada e qualificação superficial, existe apropriação efetiva e satisfatória dos espaços e mobiliários urbanos infantis. Conclui-se, portanto, que o Parque da Criança promove aos seus utilizadores oportunidades de lazer e recreação infantil no âmbito dos espaços livres públicos urbanos e que os mobiliários que os constituem atuam diretamente como atrativos, estimulando a vivência da cidade.
OFICINA DE PROJETOS DE INTERVENÇÕES NO PATRIMÔNIO
Authors: Veloso Maísa , Do Nascimento José Clewton 
Published: October 2022

Este artigo apresenta e discute uma experiência didática no âmbito do ensino de projeto de intervenções no patrimônio edificado, desenvolvida sob a forma de uma oficina semi-intensiva, nos meses de junho e julho de 2022, no Programa de Pós-graduação Profissional em Arquitetura, Projeto e Meio Ambiente (PPAPMA) da Universidade Federal do Rio Grande do Norte (UFRN). A oficina foi coordenada pelos professores autores deste texto e contou com a participação de uma doutoranda e de cinco mestrandos profissionais, citados oportunamente. A área de intervenção foi uma fração do bairro da Ribeira, no centro histórico da cidade de Natal/RN, inserida na poligonal do tombamento federal definida pelo IPHAN. Como produtos, foram propostos um masterplan para a área e três projetos de intervenção na preexistência, em dois edif´ícios de valor patrimonial e um lote semi-ocupado por uma edificação descaracterizada. A experiência atestou o significativo potencial didático-pedagógico da modalidade “Oficina de Projeto”, como ambiência favorável à reflexão crítica e à criatividade projetual, em caráter complementar ao atelier de projeto convencional, no âmbito da formação profissional continuada em Arquitetura e Urbanismo.
Estilos de apego adulto y regulación emocional en población de Quito, Ecuador
Authors: Díaz-Mosquera Elena , Merlyn Sacoto Marie-France , Latorre Vaca Grace 
Published: October 2022

El objetivo de este estudio fue explorar la asociación entre estilos de apego adulto y regulación emocional. Participaron 290 estudiantes de 18 a 25 años (M = 21.18; DE = 2.86), procedentes de varias carreras universitarias de dos instituciones de educación superior de Quito (Ecuador), seleccionados por agrupamiento casual. Para la medición se utilizaron dos instrumentos. El primero fue la escala Experiences in Close Relationships-Revised (ECR-R), validada en el contexto ecuatoriano, con la que se evaluó el tipo de apego en las relaciones de pareja. El segundo instrumento fue la escala Difficulties in Emotion Regulation Scale (DERS), en su versión original traducida al castellano, empleada para evaluar dificultades en regulación emocional. Los resultados demostraron que el apego seguro se presenta en mayor porcentaje en las participantes mujeres (60 %), que no existen diferencias por sexo en los indicadores de regulación emocional (p > .05) y que, en la población estudiada, hay una asociación entre estilos inseguros de apego adulto y desregulación emocional (p < .05). Se concluye que los modelos positivos de sí mismo y de los demás, así como los niveles bajos de ansiedad y evitación, presentes en el estilo de apego seguro, constituyen factores protectores que contribuyen a la regulación emocional.
Evaluation of the Patentability of Medicines based on plants produced in Cameroon: Case of Yaounde
Authors: Aude Périne Minyem Ngombi Afuh , Kevin Ekeme , Saurelle Maniepi , Vanessa Charlotte Soppo Lobe , Martin Nyangono Ndongo , Jeanne Mauricette Mbole Mvondo , Chimène Benga , Nga Nnanga 
Published: October 2022

Objective: Assess the patentability of medicines based on plants produced in Cameroon.
Materials and Methods: An analytical study, conducted at the Library of the Faculty of Medicine and Biomedical Sciences of the University of Yaoundé I and the Directorate of Pharmacy, Drug and Laboratories (DPML) from November 2021 to June 2022. We conducted a consecutive and non-exhaustive sampling that allowed us to identify 51 drugs and evaluate 16 of them. After that, we proceeded to assess the patentability of our samples exclusively on the criteria of novelty, inventive ability and industrial application.
Results: With regard to patentability, we obtained a patentability percentage of 75%, which shows that the potential for innovation in traditional medicine is enormous.
Conclusion: Cameroon has a rich plant heritage with high therapeutic potential, which it is important to develop. The patent, provides researchers guaranteed and solutions for the protection and enhancement of their inventions.
Formulation and Evaluation of Pluronic -Lecithin Organogel Containing Natural Moisturizing Agent for Xerosis
Authors: Trivedi Rashmi , Samrit Shraddha , Amgaokar Yogesh , Supe Urvashi , Umekar Milind , Wadher Kamlesh 
Published: October 2022

Xerosis is a common skin condition as well as a key aspect of a number of diseases associated to hereditary and acquired conditions. The objective of this study was to formulate and evaluate the pluronic lecithin organogel containing natural moisturizing agents for topical application. Different formulations of pluronic lecithin organogels were prepared by using Pluronic F127, Lecithin, Vitamin E, Aloe vera, water, sorbic acid, and potassium sorbate. The gel containing different quantities of Polaxomer, soya lecithin and polyvinyl alcohol were characterized for their mechanical properties and moisturizing capabilities.The pH of the formulations was 6.89- 7.19 reflecting no risk of skin irritation. Pluronic enhances the stability of organogel by increasing the viscosity. The polymeric films, which were produced, were thin, flexible, resistant, and suitable for application on limbs and feet. Studies showed that the film was intact for longer period of time. The results obtained showed that the polymeric films formed from organogel containing vitamin E and Aloe vera could be an innovative therapeutic approach for enhancing the moisturization of skin.
Keywords: Organogel, film forming gel, dry skin, Aloe vera, Vitamin E, soya lecithin, Pluronic F127