bluuebunny/crossref_metadata_2025_split huggingface dataset:
Work from Home: Bane for Instructors in Higher Education Institutes During Lockdown
Authors: Tabassum Farhana 
Published: March 2022

Every aspect of life has been saved by virtual reality since spring 2020 when the corona virus epidemic began to affect people's lives; the virtual world has intervened and rescued the globe in every sphere of life. Throughout the world, shopping, pleasure, employment, and education had gone online. COVID-19's global expansion has had a profound effect on education at all levels. Many people turned to technology in an attempt to maintain the teaching and learning process during the closure of schools and institutions. The COVID-19 outbreak has made working from home a reality for many. Remote working poses a new set of challenges and complications. Despite the fact that many people are now forced to work from home, it appears as though the majority of people are content with the trend and wish to continue working virtually at least part-time for the remainder of their lives.
However, the habit of working remotely presents a series of challenges that, if not properly addressed, can have a negative impact on the productivity and performance of the instructors. A wide range of issues was highlighted in the published research, but the most significant obstacles, such as an increased workload and a lack of physical activity, have a direct impact on the instructors' physical and emotional well-being. As a result, these issues are worth discussing in this editorial.
During the lockdown, instructors' workloads have continued to rise, putting a strain on their capacity to perform at their best as teachers and parents. They put in a lot of effort to assist their students with technical concerns, time management, and even filling the vacuum in the communication system by addressing students' questions about the issues of newly launched e-learning platforms. The workload nearly doubled, and they had to remain alert from morning to evening and even on weekends to continue the teaching and learning system without disruption.
As a result of the social distancing measures, people will have far fewer opportunities to engage in physical workouts, particularly if activities such as walking, cycling, and engaging in leisure activities (such as jogging in the park and going to the gym) are prohibited. Additionally, these strenuous measures make it significantly easier to remain sedentary at home for extended periods of time. The implications of this physical inactivity are predicted to be seen in a range of sectors, including health and social care, as well as teachers' mental health worldwide. While these social distancing strategies are important and vital in the modern era, our bodies and brains still require physical activity and the myriad benefits it delivers. Physical activity enhances immune function, decreases inflammation, and alleviates symptoms associated with chronic diseases. Additionally, physical activity is a good stress management method because it alleviates symptoms of anxiety and despair.
From 5-Azapyrimidine Chemistry to Thiadiazoles
Authors: Krečmerová Marcela 
Published: March 2022

The review is devoted to 5-aza- and 6-azapyrimidine nucleosides with emphasis on antileukemic agents 5‑azacytidine and 2′-deoxy-5-azacytidine (decitabine), mechanism of their action as inhibitors of DNA methylations in tumour suppressor genes and current trends in the search for their stabilized analogues. A significant contribution to 5-azacytosine chemistry is synthesis of 5-aza­cytosine acyclic nucleosides phosphonates and their prodrugs, identified as potent and selective anti-DNA viral agents. Application of 5-amino-1,2,4-thiadiazol-3-(2H)-one moiety to acyclic nucleoside analogues was inspired by hypothesis that this heterocyclic base could work as a cytosine mimic and, moreover, the reactive N-S bond could be able to attack strong nucleophiles such as the cysteine thiol group of enzymes (similarly as 5‑azacytosine). A series of prepared 1,2,4-thiadiazole derivatives provided several inhibitors of Cathepsin K and glycogen synthase kinase 3β effective in the low micromolar range.
Effect of in series and in parallel flow heater configuration of solar heat system for industrial processes
Authors: Ghabour Rajab , Korzenszky Péter 
Published: March 2022

The boiler is an enclosed vessel that transfers the energy from fuel combustion or electricity into hot water or steam. Then, this hot water or pressurized steam is used for transferring the heat to a certain heat process. Usually, the required hot water or steam keeps on varying throughout the day which also may be implied on the daily or monthly load. Therefore, several configurations of connecting the boiler into the solar heating system ensure the temperature of the final output. The boiler can be connected in series or parallel to improve the efficiency of the overall process as well as to reduce the running costs. This paper presents a simulation study of a solar heating system for industrial processes. Two flow-heater system configurations are designed for covering the heat demand of a pasteurising factory existing in Budapest, Hungary. The configuration “A” consists of a solar heating system for hot water preparation using in series flow heater configuration. While configuration “B” consists of the same solar system but with a parallel flow heater configuration. These system configurations are modelled using T*sol software for evaluating the system performance under the Hungarian climate from five different aspects: required collector area, glycol ratio, volume flow rate, relative tank capacity, and tank height-to-diameter ratio. According to the optimum design parameters, in series configuration is better than parallel by 3.14% at 45 m² collector area, 0.45% at 25% glycol ratio, 0.42% at 50 l/h · m² volume flow rate, 2.05% at 50 l/m² relative tank capacity, and 0.42% at 1.8 tank height-to-diameter ratio respectively. The results show that in series configuration is better in terms of solar fractions than parallel configuration from all five aspects.
WEB-BASED MANAGEMENT OF GOODS DEMAND APPLICATIONS IN THE NUSANTARA FRACTION OF THE OFFICE OF THE DPRD NORTH SUMATRA
Authors: Fitriani Fitriani  , Suhardi Suhardi 
Published: March 2022

The Nusantara Faction is a combination of several parties, namely the United Development Party (PPP), Perindo Party and the National Awakening Party (PKB) which are in charge of running the government. The Nusantara Faction is in the government office of the North Sumatra Province Regional House of Representatives (DPRD-SU). In order to carry out their duties smoothly, the Nusantara Faction requires work goods and equipment. The system for managing demand for goods in the Nusantara Faction is still carried out conventionally, namely data for managing demand for goods still uses paper. The current system still has a shortage of inputting data for managing demand for goods, causing quite a long time. The goal to be achieved is to make it easier for staff who work in the Nusantara Faction in carrying out and managing requests for goods in the Nusantara Faction can be run online. So it is necessary to have a web-based goods demand management application which is expected to be able to overcome the problems that occur in the Nusantara Faction. With this application, it can make it easier to input data for managing demand for goods and provide solutions to overcome problems during the process of inputting data for managing demand for goods.
Financial Impact of the Surgical Treatment of Infection on the Practice of Orthopedic Trauma
Authors: Flinn Daniel , Gurnea Taylor , Althausen Peter 
Published: March 2022

Objectives: The treatment of bone, muscle, and joint infections has been under the purview of orthopedic surgeons for years. As care has become more specialized, orthopedic surgeons are offloading infection cases to services such as general surgery or podiatry. Orthopedics as a field has already yielded portions of spine to neurosurgery, recovery to physiatrists, and foot and ankle to podiatry. The purpose of this study was to report the financial impact of infection treatment on our group practice at a busy community Level II trauma center.
Design: Retrospective Economic Review
Setting: Level II Trauma Center
Patients/Participants: All patients receiving orthopedic surgical intervention at our facility from January 1, 2018 to December 31, 2018.
Intervention: Surgical treatment of bone, muscle and joint infections.
Main Outcome Measurements: Surgical Volume, Relative Value Units, Physician Charges, Physician Collections and Payer Mix
Results: The surgical treatment of infections including irrigation and debridement, wound closure and amputations amounted to 908 out of 3700 total cases. This included 11,405 total RVUs, 5,771 work RVUs, $2,056,677 in charges and $407,479 in collections over the 2018 calendar year. This was 16.8% of total RVUs, 19% of all charges, and 15% of collections for the orthopedic trauma service. The payer mix for these patients was less favorable with a collection rate of 20% compared to a 25% average for all surgical cases.
Conclusions: The treatment of orthopedic infections represents a large proportion of surgical volume for orthopedic surgeons covering hospital call. Relinquishing control of these patients will result in significant financial loss as well as a decrease in our ability to control the episode of care and patient access in the changing healthcare environment.
Level of Evidence: Therapeutic Level III
Orthopaedic Business is the Focus of 3.4% of Articles in Top General Orthopaedic Journals.
Authors: Thomas Nicholas , Sandler Alexis , Fernandez Isaac , Simson Joshua , Tihista Mikel , Wells Matthew , Childs Benjamin 
Published: March 2022

Objectives: The purpose of this study is to compare the proportion of business articles in top general orthopaedic journals.
Design: Review.
Intervention: Categorize all articles from general orthopaedic journals with top four H-Index.
Main outcome measurement: Articles categorized as payer analysis (PA), cost analysis (CA), value-based practice (VBP), Management and human resources (HR), practice efficiency (PE) and the business of scholarship (SC).
Results and conclusions: JBJS, B&JJ, CORR, and JAAOS were identified as top orthopaedic journals. All had some level of business scholarship with an average of 3.4% of articles dedicated to business, ranging from 2 to 7%. Of business-related articles 27% of articles were cost analysis, 25% focused on practice efficiency, 22% on Value based practices, 16% payer analysis, 7% business of scholarship and 4% on human resources. The lack of scholarship regarding human resources represents a significant opportunity for improvement as a profession.
Level of Evidence: IV; Review
Keywords: Business, management, human resources, cost, value, efficiency.
(J Ortho Business 2021; 2:9-12)
The New Fire
Authors: Buchanan Ben , Imbrie Andrew 
Published: March 2022

AI is revolutionizing the world. Here's how democracies can come out on top.
Artificial intelligence is revolutionizing the modern world. It is ubiquitous—in our homes and offices, in the present and most certainly in the future. Today, we encounter AI as our distant ancestors once encountered fire. If we manage AI well, it will become a force for good, lighting the way to many transformative inventions. If we deploy it thoughtlessly, it will advance beyond our control. If we wield it for destruction, it will fan the flames of a new kind of war, one that holds democracy in the balance. As AI policy experts Ben Buchanan and Andrew Imbrie show in The New Fire, few choices are more urgent—or more fascinating—than how we harness this technology and for what purpose.
The new fire has three sparks: data, algorithms, and computing power. These components fuel viral disinformation campaigns, new hacking tools, and military weapons that once seemed like science fiction. To autocrats, AI offers the prospect of centralized control at home and asymmetric advantages in combat. It is easy to assume that democracies, bound by ethical constraints and disjointed in their approach, will be unable to keep up. But such a dystopia is hardly preordained. Combining an incisive understanding of technology with shrewd geopolitical analysis, Buchanan and Imbrie show how AI can work for democracy. With the right approach, technology need not favor tyranny.
Gut microbiota induces high platelet response in patients with ST segment elevation myocardial infarction after ticagrelor treatment
Authors: Zhang Xi , Zhang Xiaolin , Tong Fangnian , Cai Yi , Zhang Yujie , Song Haixu , Tian Xiaoxiang , Yan Chenghui , Han Yaling 
Published: March 2022

Background:Ticagrelor is a first-line drug for the treatment of acute ST elevation myocardial infarction (STEMI). However, approximately 20% STEMI patients taking ticagrelor exhibited a delayed response and the mechanism was still unclear.Methods:To explore the mechanism of the poor response of ticagrelor in post-percutaneous coronary intervention (PCI) patients, we enrolled 65 high platelet reactivity (HPR) patients and 90 controls (normal platelet reactivity [NPR]). Pharmacokinetic assessment result showed that the plasma concentrations of ticagrelor and its metabolism production, AR-C124910XX, were lower in HPR patients than controls. Further single nucloetide polymorphism (SNP) analysis identified that there is no difference in ATP binding cassette subfamily B member 1 (ABCB1) gene expression between the NPR group and the HPR group. Metagenomic and metabolomic analyses of fecal samples showed that HPR patients had higher microbial richness and diversity. Transplantation of the gut microbiota from HPR donors to microbiota-depleted mice obviously decreased plasma concentration of ticagrelor.Results:Our findings highlight that gut microbiota dysbiosis may be an important mechanism for the ticagrelor of HPR in patients with STEMI and support that modify gut microbiota is a potential therapeutic option for STEMI.Conclusions:Our findings highlight that gut microbiota dysbiosis may be an important mechanism for the ticagrelor of HPR in patients with ST elevation myocardial infarction (STEMI) and support that modify gut microbiota is a potential therapeutic option for STEMIFunding:NSFC 82170297 and 82070300 from the National Natural Science Foundation of China.
Associations between the rs5498 (A > G) and rs281432 (C > G) polymorphisms of the ICAM1 gene and atherosclerotic cardiovascular disease risk, including hypercholesterolemia
Authors: Wechjakwen Naruemon , Aroonnual Amornrat , Prangthip Pattaneeya , Soonthornworasiri Ngamphol , Phienluphon Pornpimol Panprathip , Lainampetch Jirayu , Kwanbunjan Karunee 
Published: March 2022

Background
Atherosclerotic cardiovascular disease (ASCVD) originates from complex risk factors, including age, gender, dyslipidemia, obesity, race, genetic and genetic variation. ICAM1 gene polymorphisms are a significant risk factor for ASCVD. However, the impact of the rs5498 and rs281432 polymorphisms on the prevalence of hypercholesterolemia (HCL) has not been reported. Therefore, we determine the relationships between single nucleotide polymorphisms (SNPs), including rs5498 and rs281432 on Intercellular adhesion molecule 1 gene (ICAM1) and ASCVD susceptibility in patients with HCL.

Methods
The clinical characteristics of 278 participants were assessed, and classified to groups having HCL and without HCL. ICAM1 SNPs genotyping was performed by DNA sequencing, and ICAM1 expression was measured using real-time PCR.

Results
Positive dominant model rs5498 participants had twice the risk of HCL (95% confidence interval (CI): [1.24–3.23], P = 0.005). The frequency of the G allele in rs5498 was 1.69 times higher in participants with HCL than in controls (95% CI [1.15–2.47], P = 0.007). Participants with the rs5498 AG or GG variants and high ICAM1 mRNA expression (≥3.12) had 2.49 times the risk (95% CI [1.42–4.38], P = 0.001), and those with a high LDL-C concentration (≥3.36 mmol/L) had 2.09 times the risk (95% CI [1.19–3.66], P = 0.010) of developing ASCVD compared with those with low ICAM1 mRNA and LDL-C levels. Interestingly, participants carrying the rs5498 AG or GG variants who had tachycardia (resting heart rates (RHRs) >100 beats/min) had a 5.02-times higher risk than those with a lower RHR (95% CI [1.35–18.63], P = 0.016).

Conclusions
It may consider the G allele in ICAM1 rs5498 is associated with a higher risk of ASCVD in Thai people with HCL, and is also positively associated with ICAM1 mRNA expression, LDL-C concentration, and RHR.
Effect of individualized weight management intervention on excessive gestational weight gain and perinatal outcomes: a randomized controlled trial
Authors: Xu Mei-Yan , Guo Yan-Jun , Zhang Li-Juan , Lu Qing-Bin 
Published: March 2022

It is unclear whether weight management is still effective for pregnant women with excessive weight gain in the second or third trimester in China. This study adopted individualized weight management intervention for pregnant women with abnormal weight gain in the second or third trimester, to analyze the effect of intervention by observing the gestational weight gain and perinatal outcomes. This randomized controlled trial was performed at Aerospace Center Hospital. The obstetrician determined whether the pregnant women gained too much weight in the second or third trimester according to the Institute of Medicine guidelines, and randomly divided the pregnant women who gained too much weight in the second or third trimester into the intervention group or the control group according to the inclusion and exclusion criteria. The pregnant women in the intervention group and in the control group all received routine prenatal examination and diet nutrition education by the doctors in the Department of Obstetrics and Gynecology. The intervention group underwent individualized weight management, including individualized diet, exercise, psychological assessment, cognitive intervention and continuous communication, the whole process is tracked and managed by professional nutritionists. The obstetrician collected the prenatal examination data and pregnancy outcome data of all enrolled pregnant women. The primary outcome measure was weight gain during pregnancy. A generalized linear model and a logistic regression model were used to compare the outcomes between the two groups. In total, 348 pregnant women participated in this study with 203 in the intervention group and 145 in the control group. The whole gestational weight gain in the intervention group (15.8 ± 5.4 Kg) was lower than that in the control group (17.5 ± 3.6 Kg; adjusted β = − 1.644; 95% CI [−2.660–−0.627]; P = 0.002). The percent of pregnant women with excessive weight gainbefore delivery was 54.2% (110/203) in the intervention group, which was lower than 69.7% (101/145) in the control group (adjusted RR = 0.468; 95% CI [0.284–0.769] P = 0.003). The pregnant women given the individualized weight management intervention from the second to the third trimester experienced less weight gain than that from the third trimester (15.5 ± 5.6 Kg vs. 16.2 ± 5.2 Kg), but without significant difference (P = 0.338). Lower rates of GDM, preeclampsia and gestational hypertension, higher rates of fetal distress and puerperal infection were observed in the intervention group than in the control group (all P < 0.05). Individualized weight management during the second or third trimesters is still beneficial for pregnant women who gain excessive weight and can decrease the associated adverse outcomes.
Impact of COVID 19 Pandemic on Learning Experiences of Teachers-in– Training: Case of Second Year Student Teachers
Authors: Chifamba Constance 
Published: March 2022

This study was qualitative descriptive case study. The main aim of the study was to assess the impact of COVID 19 Pandemic on the learning experiences of second year student teachers on teaching practice during the COVID 19 Pandemic. Seven student teachers from a class of 55 were purposively sampled and interviewed. Semi-structured interviews were used. Data collected was transcribed and coded . Inductive thematic analysis was used to analyse the data. Results indicate that there were both negative and positive impacts on the student teachers learning experiences due to the COVID 19 Pandemic. The major negative impacts were the disruption of the teaching practice sequence to the extent that they could not thoroughly master some of the competencies due to the limited contact time with the school pupils and mentors during the prolonged lock down, Some of the student teachers indicated that to some extent, there was also negative effect on their mental health and social life as they were continually under stress due to the unpredictableness of the outcomes of the pandemic. This resulted in learning gaps. On the other hand there were positive side of the COVID 19 Pandemic. The shift to blended learning and integration of technology in the assessment of teaching practice was a major advancement in the teacher training profession. In addition, the students developed resilience and a spirit of solidarity which gave them a sense of belonging and caring for each other during hard times.
An Appraisal of Bacteriological Profile and Antibiogram Patterns among Elderly with Urinary–Tract-Infection: A Retrospective Study
Authors: Ehimen Ferguson Ayemere , Akpan Iboro Samuel 
Published: March 2022

Background: A urinary tract infection (UTI) is an infection that can affect any portion of the urinary system (kidneys, ureters, bladder, and urethra). It's worth noting that the majority of UTIs affect the lower urinary tract. This infection has been identified as the most frequent bacterial illnesses, accounting for a significant portion of the workload in microbiological diagnostic laboratories.
UTIs account for 15.5 percent of hospitalizations in individuals over the age of 65, and it has been reported as one of the most common types of infection among the elderly, particularly those in institutionalized care.
Objectives: Our aim was to retrospectively appraise and evaluate the bacteriological profile and antibiogram patterns in elderly adults visiting our private healthcare center.
Methods: The retrospective survey was conducted on elderly patients who visited the hospital within the period of three years (October 2018- October 2021). Questionnaire designed was used to collect data from the Health Information Management unit of the hospital and these information were analyzed using SPSS 20 package with a level of significant set at p-value of < 0.05.
Results: Females made up over 70% of the study participants, while men made up 30.2 percent. A substantial percentage of the elderly (53.8%) between the ages of 60 and 65 had E. coli growth as the cause of their UTI. More than a third (33.3 percent) of the elderly between the ages of 60 and 80 had Staphylococcus and Proteus as the cause of their UTI. The majority of the elderly patients' samples showed Staphylococcus Aureus and E Coli growth, with E coli growth reported in 33.3 percent and 66.7 percent of male and female participants, respectively, and Staph. aureus growth reported in 22.2 percent and 77.8% of male and female participants' urine cultures, accordingly. The majority of the bacteria grown were susceptible to Quinolones and Ceftriazone combination medicine (Ceftriazone + Tazobactan for E. coli and Ceftriazone + Tazobactam/ Sulbactam for Staphylococcus aureus), however common hospital antibiotics such as Ceftriazone, Augmentin, Amoxicillin, Cefixime, and cefuroxime were not sensitive to the urine cultured germs.
Conclusion: The rate of UTI in the elderly was relatively high, and antibiotic resistance to routinely administered medicines was surprising. The findings of this study have bolstered the need for comprehensive national control programs to combat antibiotic resistance, as well as the establishment of Geriatric clinics and geriatric public care programs across Nigeria's private and public health institutions, whose responsibility it is to raise awareness about the dangers of UTI and to develop robust treatment plans for the elderly.