bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature and extent of intellectual disability nursing research in Ireland: a scoping review to inform health and health service research
Authors: Doody Owen , Bailey Maria E , Hennessy Therese 
Published: October 2022

ObjectivesTo capture the extent and nature of intellectual disability nursing publications in Ireland.DesignScoping review using Arksey and O’Malley approach.Data sourcesSix databases (PsycINFO, CINAHL, Medline, Academic Search Complete, Scopus, Embase) were searched along with a web-based search of the eight academic institutions delivering intellectual disability nurse education in Ireland for publications indexed from the earliest available date to the 31 December 2020.Eligibility criteriaPublications by an academic, practitioner or student working in intellectual disability practice or education in Ireland relating to intellectual disability nursing, care or education.Data extraction and synthesisData pertaining to type of paper/design, authors (academic/professional/student), year, collaboration (national/international), topic/content area and title were extracted from each paper. Data were analysed by two authors using Colorafi and Evans content analysis steps where data was tabulated, and a narrative synthesis undertaken.ResultsThe reporting of the review is in line with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) and PRISMA extension for Scoping Reviews Checklist. Database and web-based searching resulting 245 articles meeting the criteria for this review. Through content analysis the 245 articles were mapped onto six themes: supporting inclusion, future planning, aspects of health, interventions, education, professional development and research, and personal and professional accounts of caring.ConclusionsThis review highlights the extent and nature of intellectual disability publications by academic, practitioner or student working in intellectual disability nursing in Ireland together with opportunities for future growth and development. From the findings it is apparent that there is an ongoing need for intellectual disability nurses to define their role across the full trajectory of health provision and to make visible their role in person-family centred support, inclusion, and contributions in health education, health promotion and health management.
Relationship between renal function and prognosis of Chinese proliferative diabetic retinopathy patients undergoing the first vitrectomy: protocol for a prospective cohort study
Authors: Lei Chunyan , Zhang Keren , Chang Tiancong , Ran Qibo , Zhang Meixia 
Published: October 2022

IntroductionChina has the largest number of adults with diabetes aged 20–79 years (116.4 million) in 2019. Due to the socioeconomic condition or a lack of awareness of diabetic complications, many adults with diabetes have proliferative diabetic retinopathy (PDR) or renal function impairment at their first visit to the clinic for a sudden loss of vision, and pars plana vitrectomy (PPV) is required for their treatment. Risk factors for the outcomes and complications of PPV surgery in PDR patients have been widely explored in many epidemiological studies and clinical trials. However, few prospective studies have analysed the association between renal function and surgical outcomes in PDR.Methods and analysisThis is a single-centre, prospective cohort study of PDR patients with type 2 diabetes mellitus who have definite indications for PPV surgery with or without renal function impairment. We will consecutively enrol PDR patients who meet the inclusion and exclusion criteria from November 2020 to December 2023. Each participant will be followed up for at least 6 months after surgery. Clinical data from medical records and vitreous fluid will be collected.Demographic characteristics and study outcomes will be summarised using descriptive statistics. The variation will be described and evaluated using the χ² test or Kruskal-Wallis test. Generalise additive mixed models will be used to explore the association between the renal profile and surgical outcomes including BCVA, and retinal and choroidal microvasculature/microstructure. Multivariate ordinal regression analysis will be used to detect the independent association between renal profile and BCVA changes, and smooth curve fitting will be employed to briefly present the tendency.Ethics and disseminationThe trial has received ethical approval from the West China Hospital of Sichuan University. Results of this trial will be disseminated through publication in peer-reviewed journals and presentations at local and international meetings.Trial registration numberChiCTR2000039698.
How to improve patient safety in fragile, conflict-affected and vulnerable settings: a Delphi study protocol
Authors: Shaw Alexandra , O"Brien Niki , Flott Kelsey , Leatherman Sheila , Durkin Michael , Darzi Ara , Neves Ana Luisa 
Published: October 2022

IntroductionThere is a high burden of adverse events and poor outcomes in fragile, conflict-affected and vulnerable (FCV) settings. To improve outcomes, there is a need to better identify which interventions can improve patient safety in these settings, as well as to develop strategies to optimise their implementation.ObjectiveThis study intends to generate a consensus on the most relevant patient safety interventions from experts with experience on FCV settings, including frontline clinicians and managers/administrators, non-governmental organisations, policymakers and researchers.Methods and analysisThe study uses an online Delphi research approach (eDelphi). Participants will include experts from a range of backgrounds, including those working in a variety of FCV settings. Participants will be established contacts known to the research team or recruited via snowball sampling, and will be asked to identify and rank the importance of a variety of patient safety interventions. Consensus will be defined as >70% of participants agreeing/strongly agreeing or disagreeing/strongly disagreeing with a statement. Data analysis will be completed in Microsoft Excel and NVivo. The primary outcome of the study will be a list of the most relevant and applicable patient safety interventions for FCV settings.Ethics and disseminationThe study has received approval from Imperial College London Ethics Committee (reference number 20IC665). Anonymous results will be made available to the public, academic organisations and policymakers.
Evaluation of the vestibular and ocular motor screening (VOMS) as a prognostic tool for protracted recovery following paediatric sports-related concussion
Authors: Knell Gregory , Caze Todd , Burkhart Scott O 
Published: October 2022

ObjectiveTo understand the relationship between initial vestibular and ocular motor screening (VOMS) and recovery time, and the utility of VOMS to screen for protracted recovery in youth/adolescent patients with sport-related concussion (SRC).MethodsParticipants (8–18 years) who were diagnosed with an SRC within 7 days of the injury were administered the VOMS test by certified medical personnel. Recovery time (days) and protracted recovery (>30 days) were the primary outcomes. Multivariable regression models were used to evaluate the association between VOMS symptom provocation and (1) recovery time (days) and (2) protracted recovery. Measures of VOMS validity, predictive ability and receiver operator curves were used to assess VOMS as a prognostic tool to accurately classify a normal/protracted recovery.ResultsAfter adjustment, any symptom provocation across all VOMS domains was associated (p<0.05) with greater recovery time, except the convergence test (p=0.08) in females. All VOMS test thresholds (≥1 to ≥10) in males and (≥1 to ≥5) in females were associated (p<0.05) with recovery time. However, the VOMS test performed poorly among males (receiver operating characteristic (ROC) area=0.66) and failed among females (ROC area=0.56) as a prognostic tool to identify those that will have a normal/protracted recovery.ConclusionIn this sample, overall, the VOMS test was associated with recovery time (days); however, the VOMS was not a valid stand-alone prognostic tool to identify a delayed recovery, but may be useful in combination with other concussion symptomology assessments. Future studies should confirm these findings in larger samples while taking into consideration other comorbid factors that may influence recovery time.
Immunostimulatory effects of targeted thorium-227 conjugates as single agent and in combination with anti-PD-L1 therapy
Authors: Lejeune Pascale , Cruciani Véronique , Berg-Larsen Axel , Schlicker Andreas , Mobergslien Anne , Bartnitzky Lisa , Berndt Sandra , Zitzmann-Kolbe Sabine , Kamfenkel Claudia , Stargard Stefan , Hammer Stefanie , Jørgensen Jennifer S , Jackerott Malene , Nielsen Carsten H , Schatz Christoph A , Hennekes Hartwig , Karlsson Jenny , Cuthbertson Alan S , Mumberg Dominik , Hagemann Urs B 
Published: October 2022

BackgroundTargeted thorium-227 conjugates (TTCs) are an emerging class of targeted alpha therapies (TATs). Their unique mode of action (MoA) is the induction of difficult-to-repair clustered DNA double-strand breaks. However, thus far, their effects on the immune system are largely unknown. Here, we investigated the immunostimulatory effects of the mesothelin-targeted thorium-227 conjugate (MSLN-TTC)in vitroandin vivoin monotherapy and in combination with an inhibitor of the immune checkpoint programmed death receptor ligand 1 (PD-L1) in immunocompetent mice.MethodsThe murine cell line MC38 was transfected with the human gene encoding for MSLN (hMSLN) to enable binding of the non-cross-reactive MSLN-TTC. The immunostimulatory effects of MSLN-TTC were studiedin vitroon human cancer cell lines and MC38-hMSLN cells. The efficacy and MoA of MSLN-TTC were studiedin vivoas monotherapy or in combination with anti-PD-L1 in MC38-hMSLN tumor-bearing immunocompetent C57BL/6 mice. Experiments were supported by RNA sequencing, flow cytometry, immunohistochemistry, mesoscale, and TaqMan PCR analyses to study the underlying immunostimulatory effects.In vivodepletion of CD8+ T cells and studies with Rag2/Il2Rg double knockout C57BL/6 mice were conducted to investigate the importance of immune cells to the efficacy of MSLN-TTC.ResultsMSLN-TTC treatment induced upregulation of DNA sensing pathway transcripts (IL-6,CCL20,CXCL10, and stimulator of interferon genes (STING)-related genes)in vitroas determined by RNASeq analysis. The results, including phospho-STING activation, were confirmed on the protein level. Danger-associated molecular pattern molecules were upregulated in parallel, leading to dendritic cell (DC) activationin vitro. MSLN-TTC showed strong antitumor activity (T:C 0.38, p<0.05) as a single agent in human MSLN-expressing MC38 tumor-bearing immunocompetent mice. Combining MSLN-TTC with anti-PD-L1 further enhanced the efficacy (T:C 0.08, p<0.001) as evidenced by the increased number of tumor-free surviving animals. MSLN-TTC monotherapy caused migration of CD103+ cDC1 DCs and infiltration of CD8+ T cells into tumors, which was enhanced on combination with anti-PD-L1. Intriguingly, CD8+ T-cell depletion decreased antitumor efficacy.ConclusionsThesein vitroandin vivodata on MSLN-TTC demonstrate that the MoA of TTCs involves activation of the immune system. The findings are of relevance for other targeted radiotherapies and may guide clinical combination strategies.
Proposed A2C2S2-VASc score for predicting atrial fibrillation development in patients with atrial flutter
Authors: Chen Yung-Lung , Wang Hui-Ting , Chen Huang-Chung , Liu Wen-Hao , Chong Shaur-Zheng , Hsueh Shu-Kai , Chung Chang-Ming , Lin Yu-Shen 
Published: October 2022

AimsThe clinical outcome and threshold of oral anticoagulation differs between patients with solitary atrial flutter (AFL) and those with AFL developing atrial fibrillation (AF) (AFL-DAF). We therefore investigated previously unevaluated predictors of AF development in patients with AFL, and also the predictive values of risk scores in predicting the occurrence of AF and ischaemic stroke.Methods and resultsParticipants were those diagnosed with AFL between 1 January 2001 and 31 December 2013. Patients were classified into solitary AFL and AFL-DAF groups during follow-up. Finally, 4101 patients with solitary AFL and 4101 patients with AFL-DAF were included after 1:1 propensity score matching with CHA2DS2-VASc scores and their components, AFL diagnosis year and other comorbidities. The group difference in the prevalence of ischaemic stroke/transient ischaemic attack (TIA) and congestive heart failure (CHF) was substantial, that of vascular disease was moderate, and that of diabetes and hypertension was negligible. Therefore, we reweighted the component of heart failure as 2 (the same with stroke/TIA) and vascular disease as 1 in the proposed A2C2S2-VASc score. The proposed A2C2S2-VASc and CHA2DS2-VASCscores showed patients with AFL who had higher delta scores and follow-up scores had higher risk of AF development. The delta score outperformed the follow-up score in both scoring systems in predicting ischaemic stroke.ConclusionThis study showed that new-onset CHF, stroke/TIA and vascular disease were predictors of AF development in patients with AFL. The dynamic score and changes in both CHA2DS2-VASCand the proposed A2C2S2-VASc score could predict the development of AF and ischaemic stroke.
Lessons learned from ECMO support in pediatric patients with D-transposition of the great arteries: preoperative, intraoperative and postoperative
Authors: Yang Lijun , Ye Lifen , Yu Jiangen , Li Jianhua , Zhang Zewei , Shu Qiang , Lin Ru 
Published: October 2022

BackgroundExtracorporeal membrane oxygenation (ECMO) support on D-transposition of the great arteries (D-TGA) carries formidable challenges.MethodsA retrospective study was performed on pediatric patients with D-TGA supported by ECMO from July 2007 to December 2019. This study summarized the clinical experience of ECMO support in pediatric patients with D-TGA preoperative, intraoperative, and postoperative.ResultsOverall, 16 children with D-TGA received ECMO support during this period. Two (2 of 16) were supported before cardiac surgery, 3 (3 of 16) were supported postoperatively in the intensive care unit, and 11 (11 of 16) failed to wean off cardiopulmonary bypass. Two cases of preoperative ECMO support for patients with D-TGA with an intact ventricular septum and restrictive atrial septum due to severe hypoxemia died. In this study, D-TGA with coronary artery malformation and other complicated deformities died (8 of 14), whereas uncomplicated D-TGA without coronary artery malformation all survived (6 of 14). The wean-off rate of ECMO patients supported in D-TGA was 62.5% (10 of 16), while the 30-day survival rate was 44% (7 of 16).ConclusionAlthough a promising ECMO weaning rate was obtained, 30-day survival of this population was frustrating, mainly attributed to the original anatomy of coronary arteries and the concomitant deformities.
Thermodynamics of Einstein-Aether black holes
Authors: Chan R. , da Silva M. F. A. , Satheeshkumar V. H. 
Published: October 2022

AbstractWe analyze several spherically symmetric exterior vacuum solutions allowed by the Einstein-Aether (EA) theory with a non-static aether and study the thermodynamics of their Killing and universal horizons. We show that there are five classes of solutions corresponding to different values of a combination of the free parameters, $$c_{2}$$

c
2

, $$c_{13}=c_1+c_3$$

c
13

=

c
1

+

c
3

and $$c_{14}=c_1+c_4$$

c
14

=

c
1

+

c
4

, which are: (A) $$c_2 \ne 0$$

c
2

≠
0

and $$c_{13} \ne 0$$

c
13

≠
0

and $$c_{14}=0$$

c
14

=
0

, (B) $$c_2 \ne 0$$

c
2

≠
0

and $$c_{13} = 0$$

c
13

=
0

and $$c_{14} = 0$$

c
14

=
0

, (C) $$c_2 = 0$$

c
2

=
0

and $$c_{13} \ne 0$$

c
13

≠
0

and $$c_{14} = 0$$

c
14

=
0

, (D) $$c_2 = 0$$

c
2

=
0

, $$c_{13} = 0$$

c
13

=
0

and $$c_{14} \ne 0$$

c
14

≠
0

, and (E) $$c_2 = - c_{13} \ne 0$$

c
2

=
-

c
13

≠
0

and $$c_{14} \ne 0$$

c
14

≠
0

. We present explicit analytical solutions for these five cases. All these cases have singularities at $$r=0$$

r
=
0

and are asymptotically flat spacetimes and possess both Killing and universal horizons with the universal horizons always being inside the Killing horizons. Finally, we compute the surface gravity, the temperature, the entropy and the first law of thermodynamics for the universal horizons.
Constraints on neutron–mirror-neutron oscillation from neutron star cooling
Authors: Goldman Itzhak , Mohapatra Rabindra N. , Nussinov Shmuel , Zhang Yongchao 
Published: October 2022

AbstractWe address a method of limiting neutron–mirror neutron mixing ($$\epsilon _{nn'}$$

ϵ

n

n
′

) by analyzing its effect on neutron star (NS) heating. This method employs observational bounds on the surface temperature of NSs to constrain $$\epsilon _{nn'}$$

ϵ

n

n
′

. It has been suggested that the bound obtained this way is so stringent that it would exclude any discovery of $$n-n'$$

n
-

n
′

oscillation in the currently planned terrestrial experiments at various laboratories. This conclusion motivated us to critically analyze this suggestion in more detail. In this note, we point out a very interesting new effect present in nearly exact mirror models, which can significantly affect this bound. The new element is that in nearly exact mirror models there is the mirror analog of $$\beta $$
β
decay, i.e. $$n' \rightarrow p' + e' + {\bar{\nu }}'_e$$

n
′

→

p
′

+

e
′

+

ν

¯

e
′

, which creates a cloud of mirror particles $$n'$$

n
′

, $$p'$$

p
′

, $$e'$$

e
′

, $$D'$$

D
′

and He$$'$$

′

inside the NS. The resulting $$e'$$

e
′

can “rob” the energy generated by the $$n \rightarrow n'$$

n
→

n
′

transition from the NS, via $$e-e'$$

e
-

e
′

scattering enabled by the presence of a (minute) millicharge in mirror particles. Such a tiny millicharge on mirror particles is highly likely in these models. This results in energy being emitted as unobserved mirror photons via fast mirror bremsstrahlung. whose effect is to relax the stringent bounds on $$\epsilon _{nn'}$$

ϵ

n

n
′

.
Tripling down on the W boson mass
Authors: Bahl Henning , Chiu Wen Han , Gao Christina , Wang Lian-Tao , Zhong Yi-Ming 
Published: October 2022

AbstractA new precision measurement of the W boson mass has been announced by the CDF collaboration, which strongly deviates from the Standard Model prediction. In this article, we study the implications of this measurement on the parameter space of the $$SU(2)_L$$

S
U

(
2
)

L

triplet extension (with hypercharge $$Y=1$$

Y
=
1

) of the Standard Model Higgs sector, focusing on a limit where the new triplet is approximate $${\mathbb {Z}}_2$$

Z
2

-odd while the SM is $${\mathbb {Z}}_2$$

Z
2

-even. We study the compatibility of the triplet spectrum preferred by the W boson mass measured by the CDF-II experiment with other electroweak precision observables and Higgs precision data. We comprehensively consider the signals of new Higgs states at the LHC and highlighted the promising search channels. In addition, we also investigate the cosmological implications of the case in which the lightest new Higgs particle is either late decaying or cosmologically stable.
On the energetic differences of avian cryptochromes 4 from selected species
Authors: Hanić Maja , Frederiksen Anders , Schuhmann Fabian , Solov’yov Ilia A. 
Published: October 2022

AbstractCryptochromes are a class of light-absorbing proteins that have been shown to be a part of the circadian rhythm of many animals but seem to play a central role for the magnetosensing of migratory birds. Following a documented difference in the sensitivity to an external magnetic field of cryptochrome 4a proteins from migratory and non-migratory birds, a detailed analysis of inter- and intra-protein energetics is called for. The present study relies on classical molecular dynamics simulations of cryptochrome 4a from five avian species to reveal if any of the cryptochromes feature peculiarities in their internal energetics. The five avian cryptochrome 4a proteins from pigeon, European robin, zebra finch, chicken, and Eurasian blackcap are found to be highly similar in respect of their intra-energetic behaviors, while some minor differences between the cryptochromes can be ascribed to the site of specific structural differences. Particular attention has been paid to account for the interaction of the protein with the solvent, and it has been revealed that the solvent could lead to significant stabilization of the chromophore flavin adenine dinucleotide inside of the cryptochrome 4a scaffold.
Studying the Impact of Data Disclosure Mechanism in Recommender Systems via Simulation
Authors: Chen Ziqian , Sun Fei , Tang Yifan , Chen Haokun , Gao Jinyang , Ding Bolin 
Published: October 2022

Recently, privacy issues in web services that rely on users’ personal data have raised great attention. Despite that recent regulations force companies to offer choices for each user to opt-in or opt-out of data disclosure, real-world applications usually only provide an “all or nothing” binary option for users to either disclose all their data or preserve all data with the cost of no personalized service.
In this article, we argue that such a binary mechanism is not optimal for both consumers and platforms. To study how different privacy mechanisms affect users’ decisions on information disclosure and how users’ decisions affect the platform’s revenue, we propose a privacy-aware recommendation framework that gives users fine control over their data. In this new framework, users can proactively control which data to disclose based on the tradeoff between anticipated privacy risks and potential utilities. Then we study the impact of different data disclosure mechanisms via simulation with reinforcement learning due to the high cost of real-world experiments. The results show that the platform mechanisms with finer split granularity and more unrestrained disclosure strategy can bring better results for both consumers and platforms than the “all or nothing” mechanism adopted by most real-world applications.