bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual Impacts of a Glycan Shield on the Envelope Glycoprotein B of HSV-1: Evasion from Human Antibodies In Vivo and Neurovirulence
Authors: Fukui Ayano , Maruzuru Yuhei , Ohno Shiho , Nobe Moeka , Iwata Shuji , Takeshima Kosuke , Koyanagi Naoto , Kato Akihisa , Kitazume Shinobu , Yamaguchi Yoshiki , Kawaguchi Yasushi 
Published: December 2022

ABSTRACTIdentification of the mechanisms of viral evasion from human antibodies is crucial both for understanding viral pathogenesis and for designing effective vaccines. However, the in vivo efficacy of the mechanisms of viral evasion from human antibodies has not been well documented. Here we show in cell cultures that an N-glycan shield on the HSV-1 envelope glycoprotein B (gB) mediated evasion from neutralization and antibody-dependent cellular cytotoxicity due to pooled γ-globulins derived from human blood. We also demonstrated that the presence of human γ-globulins in mice and HSV-1 immunity induced by viral infection in mice significantly reduced the replication of a mutant virus lacking the glycosylation site in a peripheral organ but had little effect on the replication of its repaired virus. These results suggest that the glycan shield on the HSV-1 envelope gB mediated evasion from human antibodies in vivo and from HSV-1 immunity induced by viral infection in vivo. Notably, we also found that the glycan shield on HSV-1 gB was significant for HSV-1 neurovirulence and replication in the central nervous system (CNS) of naïve mice. Thus, we have identified a critical glycan shield on HSV-1 gB that has dual impacts, namely evasion from human antibodies in vivo and viral neurovirulence.IMPORTANCEHSV-1 establishes lifelong latent and recurrent infections in humans. To produce recurrent infections that contribute to transmission of the virus to new human host(s), the virus must be able to evade the antibodies persisting in latently infected individuals. Here we show that an N-glycan shield on the envelope glycoprotein B of HSV-1 mediates evasion from pooled γ-globulins derived from human blood both in cell cultures and mice. Notably, the N-glycan shield was also significant for HSV-1 neurovirulence in naïve mice. Considering the clinical features of HSV-1 infection, these results suggest that the glycan shield not only facilitates recurrent HSV-1 infections in latently infected humans by evading antibodies, but is also important for HSV-1 pathogenesis during the initial infection.
A Photonic Resonator Interferometric Scattering Microscope for Label-free Detection of Nanometer-Scale Objects with Digital Precision in Point-of-Use Environments
Authors: Liu Leyang , Tibbs Joseph , Li Nantao , Bacon Amanda , Shepherd Skye , Lee Hankeun , Chauhan Neha , Demirci Utkan , Wang Xing , Cunningham Brian T. 
Published: December 2022

AbstractLabel-free detection and digital counting of nanometer-scaled objects such as nanoparticles, viruses, extracellular vesicles, and protein molecules enable a wide range of applications in cancer diagnostics, pathogen detection, and life science research. The contrast of interferometric scattering microscopy is amplified through a photonic crystal surface, upon which scattered light from an object combines with illumination from a monochromatic plane wave source. The use of a photonic crystal substrate for interference scattering microscopy results in reduced requirements for high-intensity lasers or oil-immersion objectives, thus opening a pathway toward instruments that are more suitable for environments outside the optics laboratory. Here, we report the design, implementation, and characterization of a compact Photonic Resonator Interferometric Scattering Microscope (PRISM) designed for point-of-use environments and applications. The instrument incorporates two innovative elements that facilitate operation on a desktop in ordinary laboratory environments by users that do not have optics expertise. First, because scattering microscopes are extremely sensitive to vibration, we incorporated an inexpensive but effective solution of suspending the instrument’s main components from a rigid metal framework using elastic bands, resulting in an average of 28.7 dBV reduction in vibration amplitude compared to an office desk. Second, an automated focusing module based on the principle of total internal reflection maintains the stability of image contrast over time and spatial position, facilitating automated data collection. In this work, we characterize the system’s performance by measuring the contrast from gold nanoparticles with diameters in the 10-40 nm range and by observing various biological analytes, including HIV virus, SARS-CoV-2 virus, exosomes, and ferritin protein.
Impact of athlete performance and brand social value on product involvement: a mediation role of celebrity endorsement in social media
Authors: Jiang Nan , Khong Kok Wei , Gan Jen Ling , Turner Jason James , Teng ShaSha , Xavier Jesrina Ann 
Published: December 2022

PurposeNowadays, star athletes are global brand personalities. The increased popularity of the professional sport has contributed to elevating exceptional athletes to international star status. This empirical study aims to assess the impact of athlete performance and brand social value on product involvement with the mediation effect of celebrity athlete endorsement.Design/methodology/approachA quantitative survey was conducted with 399 Chinese participants. PLS-SEM is adopted to examine the associated paths and the mediating effect of celebrity endorsement.FindingsThe results demonstrate the significant impact of athlete performance and brand social value on product involvement. Celebrity endorsement partially mediates the effects of athlete performance and brand social value on product involvement.Originality/valueThis study extends understanding of celebrity athlete endorsement and provides insight into the strategic implications for Chinese social media-based marketing initiatives in the context of the recent Olympic Game in Tokyo 2021.
Effectiveness of environmental claims in preventing food waste: exploring consumer perspectives toward suboptimal food
Authors: Chang Hsiu-Hua 
Published: December 2022

PurposeSince a significant source of food waste on the consumer end is the reluctance to purchase or consume imperfect products, it is vital for businesses to learn how to affiliate their products with social and ecological causes. This study explores whether firms' communication of suboptimal food information to reduce food waste affects consumer perceptions and behaviors based on social exchange theory.Design/methodology/approachA factorial between-subjects experiment designed with 4 (environmental claims) × 3 (suboptimal food) is used to design 12 scenarios. The measurement scales of variables are adapted from the literature. ANCOVA and structural equation modelling (SEM) analyses were performed to test study hypotheses using a total of 745 valid samples collected via a web-based questionnaire after testing manipulation checks, reliability and validity.FindingsAmong the four types of environmental claims, product orientation and environmental fact claims improve consumers' attitudes, ethical judgments and purchase intentions toward suboptimal food. The effect of ethical judgments on purchase intention is higher than that of attitudes. Additionally, purchase intention is a vital predictor of sustainable consumption and plays a significant mediating role between the variables.Originality/valueThe findings of this study address gaps in the literature, which lacks investigations into the effects of communication information about suboptimal food on consumer attitudes and behaviors. Unlike traditional questionnaires using scale items to measure independent variables, the quasi-experimental design with stimulus materials used in this study can reveal the varied effects of different environmental claims.
The MNE as the “crown of creation”?: a commentary on mainstream theories of multinational enterprises
Authors: Forsgren Mats , Yamin Mo 
Published: December 2022

Purpose
The purpose of this paper is twofold: to analyse what theories assume about multinational enterprises (MNEs) when they claim these are superior and to discuss possible explanations for why MNE superiority seems to be dominant in the international business (IB) research field.

Design/methodology/approach
A common theme in mainstream IB theories is that multinational enterprises (MNEs) are superior in terms of cost efficiency and innovativeness compared with other types of organizations. A closer look at transaction cost economics (TCE)/internalization theory, evolutionary theory and dynamic capability theory reveal a bias toward MNE supremacy because of how MNEs are conceptualized as firms and therefore fail to explain the essence of “multinational advantage”. These revelations and the strong dependence on the benevolence to provide unbiased data means that MNE supremacy posited by mainstream IB theories is as much a rationalized myth as an empirical fact.

Findings
Although mainstream theories differ when it comes to the building blocks that constitute MNE supremacy, they have one attribute in common: they are silent as to why MNEs are superior compared with, for example, domestic firms or other types of economic agents. Irrespective of whether the focus is the strength of the hierarchy, the skill of managers or a common identity, nothing in the theories tells us that these factors are more pronounced in MNEs than in other types of economic actors.

Originality/value
The paper deals with the issue of multinational advantage. It claims that mainstream theories of MNEs tend to assume, explicitly or implicitly, that MNEs are superior in terms of cost efficiency and innovativeness compared with other types of economic agents. The analysis demonstrates that this tendency is a consequence of how MNEs are conceptualized as firms in the different theories as well as of the strong dependence in IB research on the benevolence of MNEs to provide unbiased data. It is concluded that MNE supremacy posited by mainstream IB theories is as much a rationalized myth as an empirical fact.
Assessing the value of supply chain management in the humanitarian context – An evidence-based research approach
Authors: Stumpf Jonas , Besiou Maria , Wakolbinger Tina 
Published: December 2022

PurposeThe research objective is to study the relevance of supply chain management in the humanitarian context, analyze supply chain expenditures and identify major cost-saving potentials and future research directions.Design/methodology/approachOur research design integrates exploratory and inductive research approaches that are based on existing literature, discussions with supply chain leaders and extensive financial data collected through field studies.FindingsSupply chain management is increasingly considered as a critical success factor for humanitarian operations and amounts on average to around 75% of the total response cost. Based on our findings, humanitarian supply chains bear tremendous potential for further improvements to provide more assistance with limited resources available.Research limitations/implicationsIn particular, humanitarian supply chains in conflict situations and procurement processes offer potential for impactful and relevant research. Whilst our study focuses on international organizations, future research should give more attention to supply chain cost structures of local actors to reveal further untapped potential.Practical implicationsOur findings equipped supply chain leaders with fact-based evidence of the value of supply chain management and supported them in strategic meetings with their executive management and donors. Furthermore, we identified major cost-saving potentials.Social implicationsFor researchers (and practitioners), our findings serve as motivation to intensify their efforts in studying and enhancing supply chain management in the humanitarian context.Originality/valueThis paper fulfils an identified need to study and provide empirical evidence of the value of supply chain management in the humanitarian context.
From servant to survivor: multimodal public service media narratives and restaurant industry identity during the COVID-19 pandemic
Authors: Nyqvist Frida , Lundgren-Henriksson Eva-Lena 
Published: December 2022

PurposeThe purpose of this research is to explore how an industry is represented in multimodal public media narratives and to explore how this representation subsequently affects the formation of public sense-giving space during a persisting crisis, such as a pandemic. The question asked is: how do the use of multimodality by public service media dynamically shape representations of industry identity during a persisting crisis?Design/methodology/approachThis study made use of a multimodal approach. The verbal and visual media text on the restaurant industry during the COVID-19 pandemic that were published in Finland by the public service media distributor Yle were studied. Data published between March 2020 and March 2022 were analysed. The data consisted of 236 verbal texts, including 263 visuals.FindingsThree narratives were identified– victim, servant and survivor – that construct power relations and depict the identity of the restaurant industry differently. It was argued that multimodal media narratives hold three meaning making functions: sentimentalizing, juxtaposing and nuancing industry characteristics. It was also argued that multimodal public service media narratives have wider implications in possibly shaping the future attractiveness of the industry and organizational members' understanding of their identity.Originality/valueThis research contributes to sensemaking literature in that it explores the role of power – explicitly or implicitly constructed through media narratives during crisis. Furthermore, this research contributes to sensemaking literature in that it shows how narratives take shape multimodally during a continuous crisis, and how this impacts the construction of industry identity.
Responsible innovation assessment tools: a systematic review and research agenda
Authors: Guimarães Cristina , Amorim Vasco , Almeida Fernando 
Published: December 2022

PurposeResponsible innovation assessment tools (RIATs) are key instruments that can help organizations, associations and individuals measure responsible innovation. Accordingly, this study aims to review the current status of research on responsible innovation and, in particular, of studies that either present the relevance of RIATs or provide empirical evidence of their adoption.Design/methodology/approachA systematic literature review is conducted to identify and review how RIATs are being addressed in academic research and the applications that are proposed. A systematic process is implemented using the Web of Science and Scopus bibliographic databases, aiming not only to summarize existing studies, but also to include a perspective on gaps and future research.FindingsA total of 119 publications were identified and included in the review process. The study identifies that RIATs have attracted growing interest from the scientific community, with a greater predominance of studies involving qualitative and mixed methods. A well-balanced mix of conceptual and exploratory studies is also registered, with a greater predominance of analysis of RIATs application domains in the past years, with greater incidence in the finance, water, energy, construction, manufacturing and health sectors.Originality/valueThis study is pioneering in identifying 16 dimensions and 60 sub-dimensions for measuring responsible innovation. It also suggests the need to include multidimensional perspectives and individuals with interdisciplinary competencies in this process.
Updated analysis of nivolumab and ipilimumab combination therapy in Japanese patients with advanced melanoma
Authors: Takahashi Akira , Namikawa Kenjiro , Ogata Dai , Jinnai Shunichi , Nakano Eiji , Yamazaki Naoya 
Published: December 2022

AbstractThe efficacy and safety of nivolumab and ipilimumab (N + I) combination therapy for Japanese patients with advanced unresectable melanoma was re‐evaluated in clinical practice. One hundred Japanese patients with advanced melanoma were included. The overall response rate was 24%; complete response (CR), 6%; partial response, 18%. The response rates were 33.3% in the systemic therapy‐naïve and 15.4% in the prior‐treatment groups, and 16.1% for patients who were treated with first‐line anti‐programmed death 1 antibody monotherapy followed by second‐line N + I therapy after progression of the disease. The response rate for cutaneous melanoma was 32.7%, and 47.8% in the naïve group. Response rates for non‐acral, acral, and mucosal melanoma were 34.9%, 25%, and 16.7%, respectively. The median progression‐free survival (PFS) for all patients was 3.25 months (6.5 and 2.5 months in the naïve and prior‐treatment groups, respectively). Median overall survival (OS) was 14.5 months (25.25 and 7.5 months in the naïve and prior‐treatment groups, respectively). There were no significant differences in PFS or OS for patients with non‐acral, acral, or mucosal melanoma. The 3‐year PFS and OS were both 100% in patients who achieved CR with combination therapy. Adverse events occurred in 89% and were grade three or higher in 56% of cases. Although direct comparisons cannot be made due to different patient backgrounds, N + I combination therapy in Japanese patients in clinical practice tended to be inferior when compared to global study and non‐Asian patients in clinical practice. The highest response rate was in the cutaneous melanoma therapy‐naïve group. The best tumor response was associated with survival outcome, and the PFS and OS were good in cases where CR was obtained. The proportion of grade three and four adverse events was as high as that in the global study.
Complicity: Methodologies of power, politics and the ethics of knowledge production
Authors: Hollin Gregory , Williams Ros 
Published: December 2022

AbstractIn this collection we develop the concept of “complicity” as a means to understand how medical sociologists might be allied in unexpected or uncomfortable ways with dominant structures of power. After giving examples of complicity from our own research, we introduce existing scholarship on complicity, describing it as a concept that comes coupled with a sense of responsibility and that is related to, yet distinct from, a range of other terms including reflexivity, collusion, guilt, and shame. We also discuss how complicity has been described to occur at the level of the institution, within theoretical frameworks, and during mundane moments that we face on a day‐to‐day basis. Building on this review, we hypothesise that medical sociology – where access to fieldsites is often hard won, where “researching up” in medical and scientific institutions is common, and where our own work frequently concerns matters central to medical institutions themselves – is a discipline wherein mundane complicity is likely. Following this gathering exercise, we introduce the interventions that comprise this collection: interventions from a diversity of sociologists of health and illness who, perhaps for the first time in written form, account for how complicities of various kinds came to shape their work and how, with varying levels of success, they have sought redress. We close by offering some insight into the process of developing this collection, celebrating its successes while also acknowledging that many gaps and complicities remain.
Exploring the feasibility of smartglass facilitated remote supervision in the emergency department: A simulation study
Authors: McTavish Arthur , Larsen Peter , Rogan Alice , Carlin Emma , Lynch Matthew , Peckler Brad 
Published: December 2022

AbstractObjectiveSmartglasses are a wearable computer technology that has potential to facilitate remote supervision to junior doctors working in different clinical settings. The present study aimed to explore the feasibility of smartglass technology to enable remote supervision of junior clinicians by senior clinicians during emergency simulation scenarios.MethodsThis was a feasibility simulation study using high‐fidelity mannequins and standardised patients. Trainee interns (TIs) and supervising clinicians (SCs) were invited to participate in two scenarios: a trauma case and a stroke case. There was a pre‐sim questionnaire. The TI wore the smartglasses in a simulated ED bay and performed patient assessment and management. Remote supervision was provided by the SC via a livestream on a remote computer. Upon completion, participants completed a survey regarding their experience comprising of Likert scale and free‐text questions.ResultsFifteen TIs and 19 SCs participated. In general feedback from TIs and SCs was positive. TIs were able to identify and treat the key diagnostic problems set during the scenarios. Free‐text survey responses provided specific feedback about what did and did not work when using the glasses.ConclusionThe present study demonstrates that smartglasses facilitated remote assistance has promise as an emergent technology and warrants further investigation in simulated and non‐simulated environments.
Prevalence of type 1 and type 2 diabetes in children and adolescents in Germany from 2002 to 2020: A study based on electronic health record data from the DPV registry
Authors: Stahl‐Pehe Anna , Kamrath Clemens , Prinz Nicole , Kapellen Thomas , Menzel Ulrike , Kordonouri Olga , Schwab K. Otfried , Bechtold‐Dalla Pozza Susanne , Rosenbauer Joachim , Holl Reinhard W. 
Published: December 2022

AbstractBackgroundTo provide estimates of the nationwide prevalence of type 1 diabetes (T1D) and type 2 diabetes (T2D) in individuals younger than 20 years of age in Germany from 2002 to 2020 and to identify trends.MethodsData were obtained from the electronic health record “Diabetes Prospective Follow‐up Registry (DPV)” specific to diabetes care. Prevalence was estimated based on prevalent cases at the end of each year for the years 2002, 2008, 2014, and 2020 per 100 000 persons assuming a Poisson distribution and directly age‐ and/or sex‐standardized to the population in 2020. Individuals younger than 20 years of age with a clinical diagnosis of T1D or 10–19‐year‐olds with T2D were eligible for inclusion in the study.ResultsThe standardized T1D prevalence per 100 000 persons was 138.9 (95% CI: 137.1; 140.6) in 2002 and 245.6 (243.1; 248.0) in 2020. The standardized T2D prevalence per 100 000 persons was 3.4 (3.1; 3.8) in 2002 and 10.8 (10.1; 11.5) in 2020. The annual percent change (APC) in prevalence declined over the three periods 2002–2008/2008–2014/2014–2020 (T1D: 6.3% [3.6%; 9.0%]/3.1% [0.7%; 5.5%]/0.5% [−1.7%; 2.85], T2D: 12.3% [5.3%; 20.8%]/4.7% [−0.6%; 10.3%]/3.0% [−1.8%; 8.0%]). From 2014 to 2020, the highest APCs were observed among 15–19‐year‐olds (T1D: 2.5% [1.3%; 3.6%], T2D: 3.4% [−0.5%; 7.5%]).ConclusionsThe increase in diabetes prevalence has slowed, but medical care should be prepared for an increase in adolescents with diabetes.