bluuebunny/crossref_metadata_2025_split huggingface dataset:
mHealth intervention to improve quality of life in patients with chronic diseases during the COVID-19 crisis in Paraguay: A study protocol for a randomized controlled trial
Authors: Escrivá-Martínez Tamara , Vara Mª Dolores , Czeraniuk Nadia , Denis Matías , Núñez-Benjumea Francisco J. , Fernández-Luque Luis , Jiménez-Díaz Alba , Traver Vicente , Llull Juan José , Martínez-Millana Antonio , Garcés-Ferrer Jorge , Miragall Marta , Herrero Rocío , Enríquez Analía , Schaefer Verena , Cervera-Torres Sergio , Villasanti Cecilia , Cabral Carmen V. , Fernández Irene , Baños Rosa Mª 
Published: November 2022

Background
Patients with chronic disease represent an at-risk group in the face of the COVID-19 crisis as they need to regularly monitor their lifestyle and emotional management. Coping with the illness becomes a challenge due to supply problems and lack of access to health care facilities. It is expected these limitations, along with lockdown and social distancing measures, have affected the routine disease management of these patients, being more pronounced in low- and middle-income countries with a flawed health care system.

Objectives
The purpose of this study is to describe a protocol for a randomized controlled trial to test the efficacy of the Adhera® MejoraCare Digital Program, an mHealth intervention aimed at improving the quality of life of patients with chronic diseases during the COVID-19 outbreak in Paraguay.

Method
A two-arm randomized controlled trial will be carried out, with repeated measures (baseline, 1-month, 3-month, 6-month, and 12-month) under two conditions: Adhera® MejoraCare Digital Program or waiting list. The primary outcome is a change in the quality of life on the EuroQol 5-Dimensions 3-Levels Questionnaire (EQ-5D-3L). Other secondary outcomes, as the effect on anxiety and health empowerment, will be considered. All participants must be 18 years of age or older and meet the criteria for chronic disease. A total of 96 participants will be recruited (48 per arm).

Conclusions
It is expected that the Adhera® MejoraCare Digital Program will show significant improvements in quality of life and emotional distress compared to the waiting list condition. Additionally, it is hypothesized that this intervention will be positively evaluated by the participants in terms of usability and satisfaction. The findings will provide new insights into the viability and efficacy of mHealth solutions for chronic disease management in developing countries and in times of pandemic.

Trial registration
ClinicalTrials.gov NCT04659746.
Discussing spiritual health in primary care and the HOPE tool—A mixed methods survey of GP views
Authors: Whitehead Ishbel Orla , Jagger Carol , Hanratty Barbara 
Published: November 2022

Background
In the UK, the General Medical Council (GMC) and Royal College of General Practitioners (RCGP) require doctors to consider spiritual health in their consultations. There are documented barriers to discussion of spiritual health, and suggested tools to help overcome them.

Aim
To investigate how comfortable general practitioners (GPs) feel about discussing spiritual health in the consultation, and whether a structured tool (the HOPE tool) would be helpful.

Design and setting
A mixed-methods online survey completed by GPs in England.

Method
A mixed methods online survey of practicing GPs in England asked about current comfort with the topic of spiritual health and use of spiritual history-taking tools. The acceptability of the HOPE tool was investigated using patient vignettes drawn from clinical practice.

Results
177 GPs responded. 88 (49.71%) reported that they were comfortable asking patients about spiritual health. GPs felt most comfortable raising the topic after a patient cue (mean difference between pre and post cue 26%). The HOPE tool was viewed as acceptable to use with patients by 65% of participants, although its limitations were acknowledged. Qualitative data showed concerns about regulator (the GMC) and peer disapproval were major barriers to discussions, especially in the case of discordance between patient and doctor background.

Conclusion
Only half of GPs are comfortable discussing spiritual health. Dedicated training, using a structured approach, with regulatory approval, may help overcome barriers to GPs discussing spiritual health. Further research into the benefits, and risks, of discussion of spiritual health in the GP consultation is recommended.
Adherence trajectory as an on-treatment risk indicator among drug-resistant TB patients in the Philippines
Authors: Huddart Sophie , Geocaniga-Gaviola Donna Mae , Crowder Rebecca , Lim Alexander Rupert , Lopez Evanisa , Valdez Chelsea Lyn , Berger Christopher A. , Destura Raul , Kato-Maeda Midori , Cattamanchi Adithya , Garfin Anna Marie Celina 
Published: November 2022

Introduction
High levels of treatment adherence are critical for achieving optimal treatment outcomes among patients with tuberculosis (TB), especially for drug-resistant TB (DR TB). Current tools for identifying high-risk non-adherence are insufficient. Here, we apply trajectory analysis to characterize adherence behavior early in DR TB treatment and assess whether these patterns predict treatment outcomes.

Methods
We conducted a retrospective analysis of Philippines DR TB patients treated between 2013 and 2016. To identify unique patterns of adherence, we performed group-based trajectory modelling on adherence to the first 12 weeks of treatment. We estimated the association of adherence trajectory group with six-month and final treatment outcomes using univariable and multivariable logistic regression. We also estimated and compared the predictive accuracy of adherence trajectory group and a binary adherence threshold for treatment outcomes.

Results
Of 596 patients, 302 (50.7%) had multidrug resistant TB, 11 (1.8%) extremely drug-resistant (XDR) TB, and 283 (47.5%) pre-XDR TB. We identified three distinct adherence trajectories during the first 12 weeks of treatment: a high adherence group (n = 483), a moderate adherence group (n = 93) and a low adherence group (n = 20). Similar patterns were identified at 4 and 8 weeks. Being in the 12-week moderate or low adherence group was associated with unfavorable six-month (adjusted OR [aOR] 3.42, 95% CI 1.90–6.12) and final (aOR 2.71, 95% 1.73–4.30) treatment outcomes. Adherence trajectory group performed similarly to a binary threshold classification for the prediction of final treatment outcomes (65.9% vs. 65.4% correctly classified), but was more accurate for prediction of six-month treatment outcomes (79.4% vs. 60.0% correctly classified).

Conclusions
Adherence patterns are strongly predictive of DR TB treatment outcomes. Trajectory-based analyses represent an exciting avenue of research into TB patient adherence behavior seeking to inform interventions which rapidly identify and support patients with high-risk adherence patterns.
A multisite randomized controlled trial of an early palliative care intervention in children with advanced cancer: The PediQUEST Response Study Protocol
Authors: Dussel Veronica , Orellana Liliana , Holder Rachel , Porth Rachel , Avery Madeline , Wolfe Joanne 
Published: November 2022

Background
The Pediatric Quality of Life and Evaluation of Symptoms Technology Response to Pediatric Oncology Symptom Experience (PQ-Response) intervention aims to integrate specialized pediatric palliative care into the routine care of children, adolescents, and young adults (AYAs) with advanced cancer.

Aims
To evaluate whether PQ-Response, compared to usual care, improves patient’s health related quality of life (HRQoL) and symptom burden (aim 1), parent psychological distress and symptom-related stress (aim 2), and family and symptom treatment activation (aim 3).

Design
Multisite, randomized (1:1), controlled, un-blinded, effectiveness trial comparing PediQUEST Response (intervention) vs usual cancer care (control).

Setting
Five US large, tertiary level pediatric cancer centers.

Participants
Children (≥2 years old)/AYAs who receive care at any of the participating sites because of advanced cancer or any progressive/recurrent solid or brain tumor and are palliative care “naïve.” Target: 200 enrolled patient-parent dyads (minimum goal: 136 dyads randomized, N = 68/arm).

Interventions
PediQUEST Response: combines patient-mediated activation (weekly feedback of patient- and parent-reported symptoms and HRQoL to families and providers using the PediQUEST web system) with integration of the palliative care team. Usual Cancer Care: participants receive usual care, which can include palliative care consultation, and use PediQUEST web to answer surveys, with no feedback.

Methods
Following enrollment, patients (if ≥5 years) and one parent receive weekly PediQUEST-Surveys assessing HRQoL (Pediatric Quality of Life Inventory 4.0) and symptom burden (PediQUEST-Memorial Symptom Assessment Scale). After a 2-week run-in period, dyads who answer ≥2 PediQUEST surveys per participant (responders), are randomized (concealed allocation) and followed up for 16-weeks. Parents answer six additional surveys (parent outcomes).

Outcomes
Primary: mean patient HRQoL score over 16-weeks as reported by a) the parent; and b) the patient if ≥5 years-old. Secondary: patient’s symptom burden; parent’s anxiety, depressive symptoms, symptom-related stress; family activation; and symptom treatment activation.

Trial registration
ClinicalTrials.gov (NCT03408314) 1/24/18. https://clinicaltrials.gov/ct2/show/NCT03408314.
Clinical course and risk factors for sleep disturbance in patients with ischemic stroke
Authors: Tsai Hui-Ju , Wong Yi-Sin , Ong Cheung-Ter 
Published: November 2022

BackgroundStudies on insomnia in patients with ischemic stroke, particularly in the acute phase, are limited. The proportion of patients with sleep disturbance during the acute stroke period who are likely to develop insomnia in subacute and chronic stages of stroke is unknown. This study aimed to investigate the risk factors for sleep disturbance and the clinical course of the disease in patients with acute ischemic stroke.MethodsThis prospective observational study included patients diagnosed with ischemic stroke between July 1, 2020, and October 31, 2021. The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) for insomnia and the eight-item Athens Insomnia Scale (CAIS-8) were used to diagnose insomnia. Beck Depression Inventory (BDI) was applied to evaluate the mood of patients. Patient reported their sleeping conditions, before stroke onset and during the acute (within 7 days) and chronic (3 months after presentation) stroke periods.ResultsIn total, 195 patients with ischemic stroke were included in this study. Of these, 34.3% (67), 37.4% (73), and 29.7% (58) presented with sleep disturbance before stroke onset and during the acute and chronic stroke periods, respectively. Of the 128 patients without insomnia before stroke onset, 15.6% (20/128) presented with insomnia symptoms 3 months after stroke onset. Moreover, 13 (12.7%) of the 102 patients without sleep disturbance during the acute stroke period developed insomnia 3 months after stroke onset. Of the 67 patients with insomnia before stroke onset 29 (43.3%) did not develop the condition 3 months after stroke onset. A higher risk of sleep disturbance was associated with atrial fibrillation, hypertension, and mood disturbance in the acute stroke period, and a higher risk of insomnia was associated with low education and mood disturbance in the chronic stroke period.ConclusionThe prevalence rates of sleep disturbance before and during the acute and chronic stroke periods were 34.3%, 37.4%, and 29.7%, respectively. The incidence of stroke-related insomnia was 15.6%. Patients with insomnia before stroke may recover after the stroke. Atrial fibrillation, hypertension, and mood disturbance were associated with a higher risk of sleep disturbance in the acute stroke period, whereas low education and mood disturbance were associated with insomnia in the chronic stroke period.
The Comic Strip Art of Jack B. Yeats, Michael Connerty (2021)
Authors: Scully Richard 
Published: November 2022

Review of: The Comic Strip Art of Jack B. Yeats, Michael Connerty (2021)
Cham: Palgrave Macmillan, 300 pp.,
ISBN 978-3-03076-892-8; ISBN 978-3-03076-893-5 (eBook), US$120.50
The Impact of Mindfulness Meditation on Battered Women
Authors: Hebel Sofia 
Published: November 2022

Defined by numerous mental and physical constituents, health behavior change can be directly influenced by Mindfulness-Based Interventions (MBIs). Neurological and psychological evi- dence suggest positive correlations between yoga and meditation practice and decreased anxiety symptomatology by individuals of domestic violence. Regulatory processes, implemented via Mindfulness-Based Cognitive Therapy (MBSR), a mechanism implemented by yoga practice, engage neural networks for varying cognitive derivatives. Applications of learning and memory models correspond to neurological bases for chronic psychiatric conditions, namely PTSD, asso- ciated with domestic violence trauma. The following cross-sectional paper addresses the underly- ing cognitive and behavioral frameworks initiating improved emotional functioning and behavior change. The term battered women will be used interchangeably with individuals of domestic vio- lence, trauma survivors, and intimate partner violence (IPV) throughout.
Keywords:Mindfulness meditation (MM), mindfulness-based interventions (MBIs), memory, learning, neurological, battered women, intimate partner violence
Effect of saturation adsorption of paper strength additives on the performance of paper
Authors: Zhao Mengxiao , Robertsén Leif , Wågberg Lars , Pettersson Torbjörn 
Published: November 2022

AbstractThe use of paper dry strength additives is one of the methods for producing packaging boards with a lower grammage while maintaining mechanical properties. In the present work, papers were formed using dissolving grade kraft fibres, kraft fibres and carboxymethylated cellulose (CMC) modified kraft fibres (C-kraft fibres), with either cationic starch (CS), anionic polyacrylamide (APAM) or anionic polyelectrolyte complexes (PECs). Fibres and sheets were characterized to evaluate how the saturation adsorption of the different strength additives influences the properties of the treated fibres and the final handsheets. The tensile index of papers made from C-kraft fibres was the highest due to the highest adsorption capacity of strength additives. Moreover, the strength additives increased the tensile index by 33–84 %, while z-directional tensile strength was increased dramatically by 46–139 %. Bending stiffness was improved by 2.6–25 %, and the combination of CS and APAM or PECs resulted in a significant improvement in bending stiffness compared to the addition of CS alone. Importantly, the strength improvement did not sacrifice the density significantly. In summary, the knowledge gained from the current study expands the understanding of strength additives and their relationship with fibres of different surface charge and the overall paper properties.
Microwave-assisted sol–gel template-free synthesis and characterization of silica nanoparticles obtained from South African coal fly ash
Authors: Imoisili Patrick Ehi , Jen Tien-Chien 
Published: November 2022

Abstract
In this study, we prepared a silica nanoparticle from South African fly ash (SAFA), using a facile microwave (MW)-assisted sol–gel template free syntheses method. Prepared silica nanoparticles (SNPMW) were characterized using X-ray fluorescence (XRF) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX), transition electron microscope (TEM), Brunauer–Emmett–Teller (S
BET) surface area analysis, and ultraviolet visible diffuse reflection spectroscopy. XRF analysis suggests SAFA as fly ash class F. The XRD pattern reveals the structural composition of SAFA and the amorphous nature of extracted SNP, while the FTIR assay shows the presence of silanol and siloxane groups. SEM and TEM analyses revealed primary silica nanoparticles were roughly spherical with sizes of about <200 nm. EDX spectra confirm the presence of SiO2. The optical bandgap of SNPMW was established to be 4.67 eV. The application of SNPMW demonstrated that it can be used to remove Pb2+ from an aqueous solution. Test results show the optimum treatment time as 60 minutes, while removal efficiency increases from 66.76 to 96.64% as the pH rises from 3 to 5, but as the pH rises above 5, the efficiency decreases. The use of an MW-assisted sol–gel preparation method gave rise to an elevated reaction rate with minimal contamination and thinner particle size SNPMW, which was utilized for the removal of Pb2+ in an aqueous solution.
Soya bean derived activated carbon as an efficient adsorbent for capture of valuable heavy metals from waste aqueous solution
Authors: Masoud Ahmed M. , El-Zahhar Adel A. , El Naggar Ahmed M. A. , Zahran Asmaa I. , Al-Hazmi Gamil A. A. , Taha Mohamed H. 
Published: November 2022

Abstract
The removal of hazardous metal ions from liquid waste effluents is very important for water as well as environmental safety. In this regard, this article discusses in detail the U(VI) uptake from aquatic environment using biomass-based Soya Bean activated carbon (labeled as AC-SB). XRD, SEM, FTIR, Raman, and BET analysis were used to characterize the synthesized AC-SB sorbent. Batch-type experiments were used to investigate the effect of various parameters on adsorption efficiency, including pH, metal-ion concentration, temperature, and contact time. The sorption experimental data have been described well with pseudo-second-order kinetic mathematical equations. The equilibrium state of the uptake reaction was 120 min. The Langmuir isotherm model accurately described the equilibrium process which declares that the uranium sorption is a monolayer and homogeneous process. The sorption capacity of the prepared AC was 32.7 mg g−1. Thermodynamic analysis explore that the U(VI) uptake process is endothermic, feasible and spontenous process. The displayed results demonstrate that the prepared AC-SB sorbent could be used as the proper material for uranium sorption from real matrix samples.
Estudio técnico y económico de cuatro variedades de quinua en la región andina central colombiana
Authors: Guerrero Paola , Hurtado Salazar Alejandro , Ceballos Aguirre Nelson 
Published: November 2022

La quinua (Chenopodium quinoa Willd) al ser un cultivo de rápido retorno económico, con altos valores nutritivos y apetecido comercialmente, viene despertando el interés de los productores, pero todavía falta información sobre los costos de producción y su rentabilidad en los mercados nacionales, impidiendo una expansión del cultivo. El objetivo de este estudio fue estimar los costos de producción y rentabilidad de cuatro variedades de quinua en la región del eje cafetero, para el mercado agroindustrial, con el fin de dar un respaldo técnico en la toma de decisiones. El estudio se llevó a cabo en la Granja Tesorito, propiedad de la Universidad de Caldas, ubicada en el municipio de Manizales (Colombia). Las cuatro variedades fueron: Dorada de Bolivia, Amarilla de Marangani, Blanca dulce Soracá y Aurora dulce Nariño. El diseño experimental fue en bloques completos al azar (BCA) con cuatro repeticiones. Fue evaluado el rendimiento (t ha-1), estimados los costos de producción y calculados los indicadores económicos: relación beneficio costo (RB/C) y un análisis de sensibilidad. Por el modelo de análisis adoptado se puede inferir que las variedades Amarilla de Marangani, Blanca dulce Soracá y Dorada de Bolivia presentaron una alta relación beneficio costo con 1,99, 1,59 y 2,34 respectivamente; así, el cultivo de quinua es una actividad rentable, siendo considerada una buena alternativa para cultivo en la región.
MOHAÇ ÖNCESİ MACAR DIŞ POLİTİKASINDA HABSBURG ORYANTASYONU
Authors: ÇAPRAZ Hüseyin Şevket Çağatay 
Published: November 2022

Habsburg diplomasisi, Macaristan tarihinde Worms’taki İmparatorluk Meclisi [Reichstag] (1521) ile Mohaç yenilgisi (1526) arasında önemli rol oynamıştır. Çasar I. Maximilian’ın mirası bölündükten ve evlilik sözleşmeleri ile Habsburg idaresi ve Macaristan arasında sıkı bağlar tesis edildikten sonra realpolitik adımlar atan Ferdinand, Macaristan üzerindeki etkisini arttırmıştır. Neticede Macarların Mohaç Muharebesi’ni kaybetmesiyle birlikte Ferdinand Macar Krallık Tahtı için harekete geçmiştir.
Belirlenen çerçeve ile çalışmada, Osmanlı ilerlemesine karşı verilen mücadelelerde siyasî, iktisadî ve beşerî olarak Habsburg desteğine ihtiyaç duyan XVI. yüzyıl Macar idaresinin vaziyeti resmedilmeye çalışılmıştır. İlaveten Macar sarayının izlediği diplomatik yöntemlerin ve dış politikadaki destek arayışının gösterilmesi amaçlanmıştır.
Bu kapsamda Mohaç Muharebesi arifesinde, Macar Kralı II. Lajos’un özellikle Habsburg siyasetindeki ülkesini temsil yeteneğine yoğunlaşılmıştır. Ayrıca Macar sarayının taleplerine, böylece Budinli elçilerin faaliyetlerine değinilirken, Habsburg idaresinin Macar Krallığı’na dair aldığı kararlar ile Lehistan ve Vatikan’ın mevcut husustaki beklentileri vurgulanmıştır. Nihayet Macar Krallığı’na yapılacak yardımın şekline, boyutuna ve Budin’in çıkarlarına nasıl hizmet ettiğine ışık tutulmuştur. Bu vasıtalarla Türk tehdidine karşı şahsî birlik [Personalunion] çatısı altındaki Jagiellon Devlet Konfederasyonu’na gösterilen ilgi tespit edilmeye çalışılmıştır.
Prescription pattern during pregnancy in the tertiary care hospital of Kolar, India: A cross-sectional study
Authors: Asha B  , Sunitha T  
Published: November 2022

Pregnancy is associated with major physiological changes in the body. Recommendation to avoid all drugs during first trimester is an unrealistic situation, a benefit risk has to be analysed before prescribing, as management of various ailments during pregnancy is equally important. This study aimed to assess the pattern of drug prescription during pregnancy.Cross sectional study was conducted at tertiary care teaching hospital by department of Pharmacology and Obstetrics and Gynecology from December 2016 to 2018 after obtaining ethical clearance from Institutional Ethics Committee. The drug prescriptions given to the antenatal women were collected after obtaining verbal consent from them and entered in a predesigned proforma. Total of 615 prescriptions were collected. The most common category of medicine was minerals/vitamins 536(46.28%). Majority of the drugs were prescribed from category A 597(51.55%) and category B 398(34.36%). Most of the prescriptions contained two drugs per prescription 301(48.9%) followed by one drug per prescription 199(32.3%). WHO prescribing indicators were compared with the finding of current studies. The average number of drugs prescribed, injectables and anti microbial agents utilized were according to WHO standards. The most commonly prescribed drugs were vitamins and minerals followed by drugs used in vomiting. Category A and B drugs were prescribed to the maximum.
Eseje z “Guardiana”
Authors: Berkeley George 
Published: November 2022

SPIS TREŚCI:
Nota
Uwagi o Collinsa „Discourse on Free-thinking” (przełożyli Tomasz Kozłowski i Tomasz Sieczkowski)
Ograniczoność wolnomyślicieli (przełożył Hubert Żuchowski)
O krótkowzroczności umysłu (przełożył Tomasz Sieczkowski)