bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting an evolutionarily conserved “E-L-L” motif in spike protein to identify a small molecule fusion inhibitor against SARS-CoV-2
Authors: Jana Indrani Das , Bhattacharya Prabuddha , Mayilsamy Karthick , Banerjee Saptarshi , Bhattacharje Gourab , Das Sayan , Aditya Seemanti , Ghosh Anandita , McGill Andrew R , Srikrishnan Syamanthak , Das Amit Kumar , Basak Amit , Mohapatra Shyam S , Chandran Bala , Bhimsaria Devesh , Mohapatra Subhra , Roy Arunava , Mondal Arindam 
Published: October 2022

Abstract
As newer variants of SARS-CoV-2 continue to pose major threats to global human health and economy, identifying novel druggable antiviral targets is the key toward sustenance. Here, we identify an evolutionarily conserved “Ex3Lx6L” (“E-L-L”) motif present within the HR2 domain of all human and nonhuman coronavirus spike (S) proteins that play a crucial role in stabilizing its postfusion six-helix bundle (6-HB) structure and thus, fusion-mediated viral entry. Mutations within this motif reduce the fusogenicity of the S protein without affecting its stability or membrane localization. We found that posaconazole, an FDA-approved drug, binds to this “E-L-L” motif and impedes the formation of 6-HB, thus effectively inhibiting SARS-CoV-2 infection in cells. While posaconazole exhibits high efficacy in blocking S protein-mediated viral entry, mutations within the “E-L-L” motif rendered the protein completely resistant to the drug, establishing its specificity toward this motif. Our data demonstrate that posaconazole restricts early stages of infection through specific inhibition of membrane fusion and viral genome release into the host cell and is equally effective toward all major variants of concerns of SARS-CoV-2, including Beta, Kappa, Delta, and Omicron. Together, we show that this conserved essential “E-L-L” motif is an ideal target for the development of prophylactic and therapeutic interventions against SARS-CoV-2.
COVID-19 vaccination in systemic lupus erythematosus: a systematic review of its effectiveness, immunogenicity, flares and acceptance
Authors: Tan Shaun Ye Song , Yee Aaron Mingyang , Sim Jackie Jia Lin , Lim Cynthia Ciwei 
Published: October 2022

Abstract

Objectives
COVID-19 infection is associated with significant morbidity in systemic lupus erythematosus but is potentially preventable by vaccination, although the impact of the myriad vaccines among SLE patients is not established. We aimed to assess the effectiveness, efficacy, acceptance and safety of COVID-19 vaccination in SLE.

Methods
We performed a systematic review of PubMed, EMBASE, CENTRAL, and Scopus publications until 8 June 2022 without language, publication year or publication status restrictions. Reports with fewer than 5 patients or incomplete information on study outcomes were excluded. Risk of bias was assessed, and results reported according to the PRISMA 2020 guidelines.

Results
We identified 32 studies (34 reports) comprising 8269 individuals with SLE. Post-vaccine COVID-19 infections ranged from 0 to 17% in 6 studies (5065 patients), while humoral and cellular immunogenicity was evaluated in 17 studies (976 patients) and 5 studies (112 patients), respectively. The pooled seropositivity rate was 81.1% (95% CI: 72.6, 88.5%, I2 = 85%, P &lt; 0.01), with significant heterogeneity and higher rates for mRNA vaccines compared with non-mRNA vaccines. Adverse events and specifically lupus flares were examined in 20 studies (3853 patients) and 13 studies (2989 patients), respectively. Severe adverse events and moderate to severe lupus flares were infrequent. The pooled vaccine acceptance rate was 67.0% (95% CI: 45.2, 85.6%, I2=98%, P &lt; 0.01) from 8 studies (1348 patients), with greater acceptance in older patients.

Conclusion
Among SLE patients, post-vaccine COVID-19 infections, severe flares, and adverse events were infrequent, while pooled seropositivity and acceptance were high, with significant heterogeneity. These results may inform shared decision-making on vaccination during the ongoing COVID-19 pandemic.

Trial registration
PROSPERO, https://www.crd.york.ac.uk/PROSPERO/, CRD42021233366.
CFD-CSD method for rotor aeroelastic analysis with free wake model
Authors: Wang Siwen , Cheng Qiyou 
Published: October 2022

Purpose
Computational fluid dynamics (CFD)/computational structural dynamics (CSD) coupling analysis is an important method in the research of helicopter aeroelasticity due to its high precision. However, this method still suffers from some problems, such as wake dissipation and large computational cost. In this study, a new coupling method and a new air load correction method that combine the free wake model with the CFD/CSD method are proposed to maintain computational efficiency whilst solving the wake dissipation problem of the prior coupling methods.

Design/methodology/approach
A new coupling method and a new air load correction method that combine the free wake model with the CFD/CSD method are proposed. With the introduction of the free wake model, the CFD solver can adopt two-order accuracy schemes and fewer aerodynamic grids, thus maintaining computational efficiency whilst solving the wake dissipation problem of the prior coupling methods.

Findings
Compared with the predictions of the prior methods and flight test data, those of the proposed method are more accurate and closer to the test data. The difference between the two methods in high-speed forward flight is minimal.

Research limitations/implications
Because of the chosen research approach, the research results may lack generalisability. Therefore, researchers are encouraged to test the proposed method further.

Originality/value
In this paper, a CFD/CSD/free wake coupling method is proposed to improve the computational accuracy of the traditional CFD/CSD coupled method and ensure the computational efficiency.
Exploring consumer behavior and attitudes toward healthy food in Slovakia
Authors: Predanócyová Kristína , Šedík Peter , Horská Elena 
Published: October 2022

PurposeThe aim of this paper is to study attitudes and perception of Slovak consumers toward healthy food in terms of consumption, as well as to identify key factors during the purchasing process.Design/methodology/approachAn online questionnaire survey was conducted using snowball sampling method in Slovakia (n = 1,138 respondents) between March and May 2021. By applying categorical principal component analysis, five latent factors were identified. Moreover, non-parametric tests (Chi-square test for independence, Kruskal–WallisHtest) were carried out to study differences between age cohorts.FindingsResults showed that Slovak consumers mostly perceived as very healthy the following food categories: fruit, vegetables, honey, juices made of fruit and vegetables, fish meat or cereals, nuts and seeds. Moreover, research has identified five latent factors, which consumers mostly consider during purchase of healthy food as follows: price-marketing factor, information and composition factor, authenticity factor, quality factor and factor of motivation.Originality/valueResearch paper gives an important insight about consumer behavior and perception toward healthy food in Slovakia. Results provide valuable information for producers in terms of marketing and communication strategies. In addition, provided information can be used by policymakers for improving food policy to foster public health in the society.
Does external assurance stimulate higher CSR performance in subsequent periods? The moderating effect of governance and firm visibility
Authors: Uyar Ali , Elmassri Moataz , Kuzey Cemil , Karaman Abdullah S. 
Published: October 2022

PurposeDrawing on legitimacy theory, this study aims to investigate whether the benefits of the external assurance process pass beyond the current period and help firms improve corporate social responsibility (CSR) performance in the subsequent periods. Furthermore, the authors examine whether corporate governance (CG) and firm visibility moderate the relationship between assurance and CSR performance.Design/methodology/approachThe authors retrieved data from Thomson Reuters from 2002 to 2019 and executed a fixed-effects (FE) panel regression analysis. The country-level sample distribution includes 63 countries with 4,625 unique firms and 29,054 data points within these countries. The authors run several robustness tests using an alternative subsample, instrumental variable regression analysis, country-industry-year FE regression analysis, excluding the financial sector and including additional control variables and regression analysis based on propensity score matching.FindingsThe findings indicate that external assurance helps firms achieve greater CSR performance in the current period and the subsequent two periods following external assurance. However, external assurance exerts its strongest positive impact on CSR performance in the current period, and its influence extends, albeit at a weaker level, to the following two periods. Furthermore, the first moderation analysis reveals that governance structure helps firms translate the assurance process into the greater social performance but does not help to achieve higher environmental performance. The second moderation analysis reveals that firm visibility/size positively moderates between the assurance process and governance and social performance but not between the assurance process and environmental performance.Originality/valueDespite the concurrent association between CSR performance and assurance being examined before, the lag-lead relationship is the novelty of the study to highlight the long-term effect of assurance on CSR performance. Besides, although the direct effect of both CG practices and firm visibility on CSR performance and the external assurance process has been investigated before, the authors extend the literature by examining the moderating effect of CG practices and firm visibility on the external assurance and CSR performance relationship. This provides a better explanation of the extent to which the effect of external assurance on CSR performance is constructed and conditioned by CG practices and firm visibility, thereby drawing attention to contingencies’ role in firms’ practices.
The relationship between distinctive capabilities system, learning orientation, leadership and performance
Authors: Arraya Marco 
Published: October 2022

PurposeThis paper conceptualised the distinctive capabilities system and tested its relationship between small and medium enterprise (SME) non-financial and financial performance, encompassing leadership and learning orientation as mediators, moderators and moderators’ mediators.Design/methodology/approachThe research design is exploratory, quantitative and cross-sectional. The study employed partial least squares path modelling for testing the direct, mediation and moderation effects, and, for testing moderated mediation, the author adopted PROCESS analysis. Before testing the hypotheses, a confirmatory factor analysis procedure was applied to the measurement model validity test.FindingsOur empirical findings confirm that (1) learning orientation has a positive and significant implication as a moderator between the distinctive capabilities system and SME performance; (2) the distinctive capabilities system has a significant relationship with leadership and learning orientation, and leadership has a significant relationship with learning orientation and (3) the distinctive capabilities system has no direct impact on performance. These findings suggest that, by nature, the distinctive capabilities system has an indirect impact on SME performance, which must be understood as a consequence of living “far-from-equilibrium” and being forced to learn and adapt to come up with better market configurations.Originality/valueThis study intends to contribute to the existing literature in three ways: (1) it proposes the distinctive capabilities system definition; (2) it highlights the system’s features and benefits that make it a core construct for SMEs surviving and thriving and (3) it shows the causal relationship between the leadership capability and learning orientation and the distinctive capabilities system and performance.
Observing, spanning and shifting boundaries: working with data in non-clinical practice
Authors: Sukovic Suzana , Eisner Jamaica , Duncanson Kerith 
Published: October 2022

Purpose
Effective use of data across public health organisations (PHOs) is essential for the provision of health services. While health technology and data use in clinical practice have been investigated, interactions with data in non-clinical practice have been largely neglected. The purpose of this paper is to consider what constitutes data, and how people in non-clinical roles in a PHO interact with data in their practice.

Design/methodology/approach
This mixed methods study involved a qualitative exploration of how employees of a large PHO interact with data in their non-clinical work roles. A quantitative survey was administered to complement insights gained through qualitative investigation.

Findings
Organisational boundaries emerged as a defining issue in interactions with data. The results explain how data work happens through observing, spanning and shifting of boundaries. The paper identifies five key issues that shape data work in relation to boundaries. Boundary objects and processes are considered, as well as the roles of boundary spanners and shifters.

Research limitations/implications
The study was conducted in a large Australian PHO, which is not completely representative of the unique contexts of similar organisations. The study has implications for research in information and organisational studies, opening fields of inquiry for further investigation.

Practical implications
Effective systems-wide data use can improve health service efficiencies and outcomes. There are also implications for the provision of services by other health and public sectors.

Originality/value
The study contributes to closing a significant research gap in understanding interactions with data in the workplace, particularly in non-clinical roles in health. Research analysis connects concepts of knowledge boundaries, boundary spanning and boundary objects with insights into information behaviours in the health workplace. Boundary processes emerge as an important concept to understand interactions with data. The result is a novel typology of interactions with data in relation to organisational boundaries.
Knowledge sharing through empowering leadership: the roles of psychological empowerment and learning goal orientation
Authors: Khatoon Areela , Rehman Saif Ur , Islam Talat , Ashraf Yasir 
Published: October 2022

Purpose
Knowledge sharing has become necessary for organizations as it is a source of competitive advantage. Therefore, this study aims to investigate how empowering leadership through psychological empowerment encourages employees’ knowledge-sharing (KS) behavior. This study further explores the moderating role of learning goal orientation (LGO) between psychological empowerment and KS behavior.

Design/methodology/approach
This study collected data from 423 employees working in manufacturing and service organizations in two waves on convenience basis to tackle common method variance. The data were analyzed through structural equation modeling.

Findings
The results revealed that empowering leadership helps employees modify their KS behavior both directly and indirectly in the presence of psychological empowerment. Moreover, individuals high in LGO are more likely to involve in KS behavior when psychologically empowered.

Research limitations/implications
This study used a cross-sectional design and suggests management focus on their working environment to enhance knowledge sharing among employees, which is possible through empowering leaders. The study further suggests management not ignore individual attributes during recruitment.

Originality/value
Drawing upon job characteristics model and social exchange theory, this study explores the mediating role of psychological empowerment between empowering leadership and KS behavior and the moderating role of LGO on the association between psychological empowerment and KS behavior.
Climate change framing in the communication of CSR policies: the Secil Group example
Authors: Melchiades Soares Andréia 
Published: October 2022

PurposeThe cement industry's environmental implications place climate change at the centre of sector organisations' corporate social responsibility (CSR) policies, such as the Secil Group. The organisation's CSR policies definition, narrative framing and communication are fundamental, as they can affect its reputation. This article aims to highlight the climate change framing in the Secil Group sustainability report (SR) narrative.Design/methodology/approachThe framing theory is applied to analyse the international and sectoral climate change regulatory measures and the Secil Group SR. Document analysis is used to characterise Secil SR as a communication tool. Qualitative content analysis is used to highlight how Secil and the international and sectoral regulatory measures on climate change frame their narrative and compare each other.FindingsThe international and sectoral regulatory measures on climate change and the Secil's SR broadly frame climate change, using ethical, efficiency and effectiveness, communication and relations and law and regulation framings. The Secil's Group SR also highlights the financial frame, exposing the challenge of reconciling economic with collective interests. There is room for researchers to explore the concepts of CSR, sustainability and environment, social and governance (ESG) through the lens of complementarity.Originality/valueThis study shows that the Wehmeier and Raaz (2012) model, created to study transparency, can be applied to other communication studies. This paper explores a case study and, for this reason, is not generalisable. Although, the method and theoretical framework can be applied to any organisation.
Health communication for behavior change: evolution of a marketing framework
Authors: Arora Sonal , Sagar Mahim 
Published: October 2022

PurposeThis study aims to present a novel framework of “communication-led behavioral intention” in an effort to aid in the process of planning and coordinating social marketing campaigns on difficult subjects that go against social conventions, including the proper postnatal nutrition practices.Design/methodology/approachThe study followed a quasi-experimental research design. Health communications (public service announcements) were shown to the women aged 18–65 years and responses were collected using a quantitative questionnaire. Structural equation modeling with exploratory and confirmatory factor analyses was used to investigate the linkage between the factors that influence breastfeeding outcomes.FindingsA strong positive impact of contextual communication was confirmed empirically on the behavioral intention to follow and recommend exclusive breastfeeding. Three communication-specific factors – “content quality,” “message clarity” and “belief in message” – were found to play a pivotal role in inducing the “behavioral intention.” These relationships were found to be mediated by “empathy” which is an emotional state experienced out of the respondent’s ability to sense the thoughts and feelings of the characters in the communication.Originality/valueThis study is one of the few attempts on measuring breastfeeding outcomes using theoretical constructs. The framework suggested in the study has a lot of potential in assisting practitioners and researchers to develop effective interventions on complex topics that challenge social norms. Further, this paper offers important insights on the women with limited decision-making capacity on breastfeeding and child care.
The effect of cigarette and e‐cigarette taxes on prescriptions for smoking cessation medications
Authors: Maclean Johanna Catherine , Khan Tamkeen , Tsipas Stavros , Pesko Michael F. 
Published: October 2022

AbstractObjectiveTo test the effect of cigarette and e‐cigarette taxes on prescriptions for smoking cessation medications.Data SourceSymphony Health, IDV all‐payer prescription claims data for the United States over the period 2009–2017. Prescription fills for smoking cessation products were provided at the patient's age, patient's sex, brand/generic, payment type, year, and quarter levels.Study DesignWe study the effect of state‐level cigarette and e‐cigarette tax rates on prescriptions for smoking cessation medications using two‐way fixed effect modified difference‐in‐differences regressions. We also use a multiperiod difference‐in‐differences estimator robust to bias from dynamic and heterogeneous treatment effects with a staggered policy rollout.Data Collection/Extraction MethodsWe use fills for Chantix, Zyban, and their generics, as well as Food and Drug Administration‐approved nicotine replacement therapies that are paid for by insurance.Principal FindingsWe observe no statistically significant change in prescription fills following an increase in the e‐cigarette tax rate, though we are unable to rule out potentially large effects. However, following a $1.00 increase in the cigarette tax rate, we observe a 1052 increase in prescription fills per 100,000 adults (95% CI: 57, 2046; 4.2% increase). The effect of cigarette taxes on prescription fills was particularly large for 18–34 year‐olds.ConclusionsOur findings suggest that, during a period when e‐cigarettes are widely available, cigarette tax increases remain effective in increasing use of these medications, but e‐cigarette taxes do not increase use of these medications.
Rho 1 participates in parasitoid wasp eggs maturation and host cellular immunity inhibition
Authors: Wang Ruijuan , Lin Zhe , Zhou Lizhen , Chen Caihua , Yu Xianhao , Zhang Junjie , Zou Zhen , Lu Zhiqiang 
Published: October 2022

AbstractEndoparasitoid wasps introduce venom into their host insects during the egg‐laying stage. Venom proteins play various roles in the host physiology, development, immunity, and behavior manipulation and regulation. In this study, we identified a venom protein, MmRho1, a small guanine nucleotide‐binding protein derived from ovary in the endoparasitoid waspMicroplitis mediatorand found that knockdown of its expression by RNA interference caused down‐regulation of vitellogenin and juvenile hormone, egg production, and cocoons formation in the female wasps. We demonstrated that MmRho1 entered the cotton bollworm's (host) hemocytes and suppressed cellular immune responses after parasitism using immunofluorescence staining. Furthermore, wasp MmRho1 interacted with the cotton bollworm's actin cytoskeleton rearrangement regulator diaphanous by yeast 2‐hybrid and glutathione s‐transferase pull‐down. In conclusion, this study indicates that MmRho1 plays dual roles in wasp development and the suppression of the host insect cellular immune responses.