bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food intolerances in children and adolescents in Switzerland
Authors: Légeret Corinne , Lohmann Clarissa , Furlano Raoul I. , Köhler Henrik 
Published: December 2022

Abstract
Adverse food reactions have become an important health concern in pediatrics. There are discrepancies between diagnosed and self-reported food allergies and intolerances, leading to food avoidance with possible psychological and nutritional implications in the latter. There is no data available so far on the number of children and adolescents, who reduce or completely avoid certain foods in their diet. The aim of this study was to determine the prevalence of children and adolescents in the Northwest of Switzerland, who omit foods from their diet because of a self-reported intolerance, as well as the prevalence of children and adolescents who eliminate well-tolerated foods for presumed health reasons. This is a cross-sectional study conducted in the Children’s hospitals of Aarau and Basel (Switzerland) and in 4 pediatric private practices. A total of 2036 children and adolescents (54% male and 46% female) between 1 month and 18 years (mean age: 7.4 years) were included, of which 316 (16%) participants reported to avoid foods due to intolerance. Lactose intolerance is the most frequent one. In 55% of all cases, no medical tests had been performed to confirm such an intolerance. Avoiding tolerated foods for presumed health reasons was stated by 251 (12%) participants. Conclusions: Clinicians should be aware of the high frequency of food avoidance in the pediatric population due to true intolerance, functional diseases, or due to lifestyle reasons. Milk is the most avoided food and half of the affected patients avoid foods without guidance by professional dieticians, therefore risking possible negative impacts on their physical and mental health. Pediatricians should perform further investigations or advise nutritional guidance if an avoidance of foods or specific diets occurs.

What is Known:• The prevalence of food intolerances in children and adolescents is unknown.• Eating behavior in children is influenced by the consumption of social media.

What is New:• Based on this large cross-sectional study, it was shown that 16% of children and adolescents avoid foods, half of them without any medical advice.• Food avoidance is common among this Swiss cohort of children because of different reasons: lifestyle habits, functional diseases, true intolerances with possible consequences such as micronutrient deficiencies if not properly monitored.
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in patients with peritoneal surface malignancies (PSM): a prospective single-center registry study
Authors: Jansen-Winkeln B. , Eberth J. , Moulla Y. , Mehdorn M. , Niebisch S. , Schierle K. , Bläker H. , Lordick F. , Gockel I. , Thieme R. 
Published: December 2022

Abstract
Purpose
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new, palliative approach for patients with peritoneal surface malignancies (PSMs). Its main goals are to control symptoms and ascites. For this experimental procedure, treatment efficacy and patient safety need to be closely monitored.

Methods
We performed a prospective registry study for patients with PSMs. Cisplatin (C) (7.5 mg/m2 body surface) and doxorubicin (D) (1.5 mg/m2) were administered laparoscopically via PIPAC.

Results
Between November 2015 and June 2020, we recorded data from 108 patients and 230 scheduled procedures. Tumor burden, patient fitness, quality of life, operating time and in-hospital stay remained stable over consecutive procedures. We recorded 21 non-access situations and 14 intraoperative complications (11 intestinal injuries, and three aspirations while inducing anesthesia). Three or more previous abdominal surgeries or cytoreductive surgery (CRS) with intraperitoneal hyperthermic chemoperfusion (HIPEC) were risk factors for non-access and intestinal injuries (χ2, p ≤ 0.01). Five Grade IV and three Grade V postoperative complications according to the Clavien–Dindo Classification (CDC) occurred. Median overall survival was 264 days (interquartile range 108–586). Therapies were primarily discontinued because of death (34%), progressive (26%), or regressive (16%) disease.

Conclusion
PIPAC is effective in stabilizing PSMs and retaining quality of life in selected patients. Earlier abdominal surgeries and CRS with HIPEC should be considered when determining the indication for PIPAC. Randomized controlled studies are needed to evaluate PIPAC’s therapeutic benefits compared to systemic chemotherapy (sCHT) alone.

Trial registration
NCT03100708 (April 2017).
‘It made me feel part of the team, having my homework to do’ — women and specialist nurse experiences of remote follow-up after ovarian cancer treatment: a qualitative interview study
Authors: Kennedy Fiona , Shearsmith Leanne , Holmes Marie , Velikova Galina 
Published: December 2022

Abstract
Purpose
Ovarian cancer patients require monitoring for relapse post-treatment, and alternative follow-up pathways are increasing, which require in-depth exploration to ensure acceptability and inform implementation. This study aimed to explore women and specialist nurses’ experiences of participating in a feasibility study of an electronic patient-reported outcome (ePRO) follow-up pathway after ovarian cancer treatment.

Methods
The feasibility study incorporated an ePRO questionnaire, blood test and telephone consultation with a specialist nurse, instead of face-to-face hospital visits. All women and the nurses involved were invited to take part in nested semi-structured interviews. Interviews were recorded and transcripts analysed using framework analysis.

Results
Twenty interviews were conducted (16 out of 24 women who took part in the feasibility study and all 4 nurses). Four themes were identified: (1) readiness and motivators, (2) practicalities and logistics, (3) personal impact and (4) future role. An overarching theme highlighted how women strived to seek reassurance and gain confidence. Most women and nurses were positive about the ePRO pathway and would happily continue using it.

Conclusion
This work provides invaluable insight into the experiences of women on remote ePRO follow-up post-treatment. Important logistic and implementation issues were identified, which should inform future large-scale work to introduce and evaluate remote ePRO methods in cancer follow-up. This work highlights the key factors influencing women’s readiness and acceptability of an ePRO pathway, and how services should be carefully designed to ensure patients feel reassured and confident post-treatment. Furthermore, it highlights that flexibility and patient preference should be considered in remote service delivery.

Trial registration
ClinicalTrials.gov ID: NCT02847715 (first registered 19 May 2016).
High-field/High-frequency EPR Spectroscopy in Protein Research: Principles and Examples
Authors: Möbius Klaus , Savitsky Anton 
Published: December 2022

AbstractDuring the last decades, the combined efforts of biologists, chemists, and physicists in developing high-field/high-frequency EPR techniques and applying them to functional proteins have demonstrated that this type of magnetic resonance spectroscopy is particularly powerful for characterizing the structure and dynamics of stable and transient states of proteins in action on biologically relevant time scales ranging from nanoseconds to hours. The review article describes how high-field EPR methodology, in conjunction with site-specific isotope and spin-labeling strategies, is capable of providing new insights into fundamental biological processes. Specifically, we discuss the theoretical and instrumental background of continuous-wave and pulse high-field EPR and the multiple-resonance extensions EDNMR, ENDOR, TRIPLE, ESEEM, PELDOR, and RIDME. Some emphasis is placed on a balanced description of both the historical spadework and the achieved performance of advanced EPR at 95 GHz and 360 GHz. This culminates in a coherent treatment of state-of-the-art research of high-field EPR in terms of both instrumentation development and application to representative protein complexes such as cofactor binding sites in photosynthesis.
Säuglings‑, Kinder- und Jugendlichen- (SKJ) Psychotherapien während der Covid-19 Pandemie: Ergebnisse einer Studie unter psychodynamischen Psychotherapeut*innen in Österreich
Authors: Fiala-Baumann Brigitte , Ploner Helga , Witzmann Dominik , Jesser Andrea 
Published: December 2022

Zusammenfassung
Fragestellung
Diese explorative Studie untersucht die Situation der Säuglings‑, Kinder- und Jugendlichen- (SKJ) Psychotherapien während der Covid-19 Pandemie in Österreich.

Methodik
23 psychodynamisch arbeitende Psychotherapeut*innen nahmen an einer Online-Umfrage teil, die quantitative und qualitative Daten generierte. Offene Fragen zu subjektiv wahrgenommenen Veränderungen wurden mithilfe der qualitativen Inhaltsanalyse ausgewertet.

Ergebnisse
Insgesamt sank die Anzahl an Psychotherapien insbesondere bei den Säuglings- und Kleinkind-Psychotherapien. Die Zahl der Kinder und Jugendlichen-Psychotherapien nahm zunächst ab, stieg nach dem ersten Lockdown aber an. Große Nachfrage wurde zuletzt vor allem bei Jugendlichenpsychotherapien wahrgenommen. Anpassungsleistungen an sich ändernde Bedingungen und Settings erforderten große Flexibilität der Psychotherapeut*innen, die mit Fortschreiten der Pandemie zunehmend an ihre Belastungsgrenzen kamen. Befragte beobachteten eine Zunahme an Symptomen sowie einen gestiegenen Bedarf an Eltern- und Vernetzungsarbeit mit Institutionen.

Schlussfolgerungen
Tele-Psychotherapie kann vor allem mit jüngeren Kindern Präsenztherapie nicht ersetzen. Ergebnisse deuten auf eine Unterversorgung dieser Zielgruppe hin. Dies, sowie die beobachtete Zunahme an Symptomen bei älteren Kindern und Jugendlichen, ist gesellschaftspolitisch und gesundheitsökonomisch ein großes Thema und erfordert dringend einen weiteren Ausbau der Versorgungsnetzwerke.
Electroconvulsive therapy in children and adolescents: results from a population‑based study utilising the Swedish National Quality Register
Authors: Rask Olof , Nordenskjöld Axel , Johansson Björn Axel , Movahed Rad Pouya 
Published: December 2022

AbstractElectroconvulsive therapy (ECT) is effective and safe for adults with severe depression, but less studied in adolescents. Here, we examined the indications, prevalence, practice, response and remission rates, and side effects in young people treated with ECT in Sweden. We also examined the usage of ECT in the transition to adult psychiatry. Using data from national patient registers and the Swedish National Quality Register for ECT (Q-ECT), we identified patients aged up to 19 years treated with ECT over a 5-year study period. Response and remission rates were analysed using the Clinical Global Impression (7-point scale)-Improvement (CGI-I) and Severity (CGI-S). A total of 118 individuals were identified, of which 105 were also enrolled in the Q-ECT. The most common indication for ECT was depression (68%; n = 80). Adolescents aged < 18 years were more severely ill before treatment than those aged 18 years (P < 0.01). Three of the hospitals in Sweden treated the majority of adolescents < 18 years old. The median number of sessions in each ECT series was seven. Unilateral placement of the electrodes was the most common (88%; n = 99). Fifty-seven percent (n = 54) of the patients responded (CGI-I, 1–2) to the treatment; remission (CGI-S, 1–2) was achieved by 32% (n = 30). Psychotic symptoms were associated with a higher response rate in patients with depression (P = 0.038). A deterioration of memory compared to pre-treatment was reported in six patients. ECT was associated with high response and remission rates in adolescents with severe psychiatric disorders after non-response to medication.
Hessian averaging in stochastic Newton methods achieves superlinear convergence
Authors: Na Sen , Dereziński Michał , Mahoney Michael W. 
Published: December 2022

AbstractWe consider minimizing a smooth and strongly convex objective function using a stochastic Newton method. At each iteration, the algorithm is given an oracle access to a stochastic estimate of the Hessian matrix. The oracle model includes popular algorithms such as Subsampled Newton and Newton Sketch, which can efficiently construct stochastic Hessian estimates for many tasks, e.g., training machine learning models. Despite using second-order information, these existing methods do not exhibit superlinear convergence, unless the stochastic noise is gradually reduced to zero during the iteration, which would lead to a computational blow-up in the per-iteration cost. We propose to address this limitation with Hessian averaging: instead of using the most recent Hessian estimate, our algorithm maintains an average of all the past estimates. This reduces the stochastic noise while avoiding the computational blow-up. We show that this scheme exhibits local Q-superlinear convergence with a non-asymptotic rate of $$(\varUpsilon \sqrt{\log (t)/t}\,)^{t}$$

(
Υ

log
(
t
)
/
t

)

t

, where $$\varUpsilon $$
Υ
is proportional to the level of stochastic noise in the Hessian oracle. A potential drawback of this (uniform averaging) approach is that the averaged estimates contain Hessian information from the global phase of the method, i.e., before the iterates converge to a local neighborhood. This leads to a distortion that may substantially delay the superlinear convergence until long after the local neighborhood is reached. To address this drawback, we study a number of weighted averaging schemes that assign larger weights to recent Hessians, so that the superlinear convergence arises sooner, albeit with a slightly slower rate. Remarkably, we show that there exists a universal weighted averaging scheme that transitions to local convergence at an optimal stage, and still exhibits a superlinear convergence rate nearly (up to a logarithmic factor) matching that of uniform Hessian averaging.
Insect netting: effect of mesh size and shape on exclusion of some fruit pests and natural enemies under laboratory and orchard conditions
Authors: Chouinard G. , Pelletier F. , Larose M. , Knoch S. , Pouchet C. , Dumont M.-J. , Tavares J. R. 
Published: December 2022

AbstractTo improve exclusion systems for fruit trees, insect nets of various types were evaluated for their permeability to different beneficial and pest species, under laboratory and field conditions. Pests studied were the apple maggot, Rhagoletis pomonella (Diptera: Tephritidae) and the spotted wing drosophila, Drosophila suzukii (Diptera: Drosophilidae). Beneficials were Aphidoletes aphidimyza (Diptera: Cecidomyiidae), Aphidius matricariae (Hymenoptera: Braconidae) and Aphelinus abdominalis (Hymenoptera: Aphelinidae). Mesh nets with five different apertures (square, rectangle, triangle, rhombus and hexagon) and six different sizes (from 0.4 to 2.8 mm) were 3D-printed from strands of polylactic acid and tested in the laboratory along with two commercially available nets made of polyethylene. The physical and behavioral characteristics of the six studied species affected their ability to cross the nets. For an equal size (open area), the intrusion rate was generally greater through the square- and/or hexagonal-shaped meshes. Rectangular-shaped apertures totally excluded the apple maggot in both laboratory and field trials, provided their shortest side did not exceed 1.9 mm. For the spotted wing drosophila, a maximum of 1.0 mm was similarly required for exclusion in the laboratory. The shape factor (length/width ratio) of the apertures appeared to affect net selectivity. Field trials confirmed that more aphid predators and leafroller parasitoids colonized trees covered with larger mesh nets (2.3 × 3.4 mm), while still excluding the apple maggot. Thus, for a similar aperture size (area), an elongated rectangular-shaped mesh appears to facilitate access for beneficials, while continuing to provide effective protection against apple pests.
The consequences of debris flows in Brazil: a historical analysis based on recorded events in the last 100 years
Authors: Cabral Victor , Reis Fábio , Veloso Vinicius , Correa Claudia , Kuhn Caiubi , Zarfl Christiane 
Published: December 2022

AbstractThis study aims at providing an overview of the socioeconomic consequences that debris-flow events have caused in Brazil, positioning the country in the international scenario and identifying areas where targeted actions are necessary. The analysis is conducted by calculating the debris-flow mortality rate (MR) and by using the so-called F-N plots (frequency of events that have caused N or more fatalities vs. the number of fatalities), based on a compilation of debris-flow-related disasters from 1920 to 2021. In total, 45 debris-flow events were documented in the considered period, responsible for 5771 fatalities and more than 5.5 billion USD in economic losses. The Serra do Mar Mountain Range is the main site of reported debris-flow occurrences (64.5%), followed by Serra da Mantiqueira (13.3%), and Serra Geral (13.3%). Southeast Brazil (SEB) is the region most affected by debris-flow events, due to the highest population density and the development of several cities in hilly areas, such as Petrópolis (Rio de Janeiro state) and Cubatão (São Paulo state). The debris-flow MR of SEB is higher than any other region in Brazil, pushing the national debris-flow MR upwards, and the F-N curve of SEB consolidates the region as the one with the highest risk to the phenomenon, indicating a higher probability of fatal events. The F-N plots further show that debris-flow events in Brazil represent a higher societal risk than in countries such as China, Japan and Italy. While there are differences in country size and the scale effect should be considered, these results highlight the urgent need for investments in disaster prevention and preparedness programs.
On the fractal properties of cosmic rays and Sun dynamics cross-correlations
Authors: Sierra-Porta D. 
Published: December 2022

AbstractWe investigate the cosmic rays and ten physical parameters of heliosphere behavior considering the scaling features of their temporal evolution. Our analysis start with the cosmic rays measurements by a neutron monitor station located in Moscow, as well sunspot, Ap index, Na/Np, Alfven mach number, DST index, Kp index, Plasma beta ($\beta $
β
), Proton temperature, $F_{10.7}$

F
10.7

index and Field magnitude $|B|$
|
B
|
(Interplanetary Magnetic Field, IMF), for the period 1976 to early 2020. Each of these datasets was analyzed by using the Multifractal Detrended Fluctuation Analysis and Multifractal Detrended Cross-Correlation Analysis in order to investigate intrinsic properties, like self-similarity and the spectrum of singularities. The main result obtained is that the cosmic rays time series as well the 10 heliospheric parameters exhibit positive long-range correlations with multifractal behavior.
The Happiness that Qualifies Nonduality: Jñāna, Bhakti, and Sukha in Rāmānuja’s Vedārthasaṃgraha
Authors: Ram-Prasad Chakravarthi 
Published: December 2022

AbstractThe great eleventh-century figure, Rāmānuja, belonged to the Śrīvaiṣṇava community that worshiped the divine as Viṣṇu-with-Śrī, the Lord-and-Consort. But he also embarked on a project to develop an interpretation of the first-century Vedāntasūtra, which presented the supposedly core teachings of the major Upaniṣads, traditionally the last segment of the sacred corpus of the Vedas. Rāmānuja sought to reconcile the devotional commitments of Śrīvaiṣṇavism—which was built on the human yearning for the divine that was incomprehensibly Other while graciously accessible—with the conceptual demands of the Vedānta in which a profound identity between the individual self (ātman) and the impersonal, ultimate explanatory principle (brahman) was taught. This reconciliation of difference and identity came to be called “Qualified Nondualism.” In his earliest work, the Vedārthasaṃgraha, one of the ways Rāmānuja points to reconciliation is through identifying a single state of consciousness as both cognition of nonduality (the Vedāntic project) and the emotionally valent experience of happiness (the supreme expression of the human encounter with the divine). It does not seem that he systematically pursues this conception of how a state can be both cognitive and affective, and such an analysis will require independent philosophical analysis. Thus, this article argues that if a state of consciousness were indeed both cognitive and affective in this way, we would have a full explanation for how the devotional approach of a human being to Viṣṇu-with-Śrī can also be the self’s realization of identity with brahman.
Perceived tax audit aggressiveness, tax control frameworks and tax planning: an empirical analysis
Authors: Blaufus Kay , Reineke Jakob , Trenn Ilko 
Published: December 2022

AbstractThis paper examines whether a perceived increase in tax audit aggressiveness is associated with lower tax planning effort and a higher quality of internal tax control frameworks. Using survey data on corporate tax functions from approximately 200 firms from different countries, contrary to expectations, we find that neither internal nor external resources devoted to tax planning are lower for firms that perceive an increase in tax audit aggressiveness. Nevertheless, for these firms, we find a positive association with the quality of their tax control framework and their investments in the reputation management and communication skills of their tax department staff. In line with this, we find that an increase in perceived audit aggressiveness is directly (indirectly) associated with an increase in resources allocated to the tax function “controversy and audit defense” (“risk management and governance”). In addition, our results show a positive relationship between the quality of the tax control framework and the need for comprehensive improvements in human capital and internal processes, suggesting that the tax control framework affects the firms' perceptions of their tax capabilities and drives organizational changes. Overall, these findings are in line with the rationale that an increase in audit aggressiveness changes the costs of compliance errors such that firms improve the quality of their tax control framework to reduce future errors. In contrast, it remains unclear whether tax audit aggressiveness actually changes tax planning behavior, as we find no negative association with the firms' investment in tax planning.
Working from home and management controls
Authors: Flassak Konstantin , Haag Julia , Hofmann Christian , Lechner Christopher , Schwaiger Nina , Zacherl Rafael 
Published: December 2022

AbstractThe Covid-19 pandemic and the corresponding shift toward working from home (WFH) amplifies control problems within organizations and poses severe challenges for management control as employees’ tasks are difficult to observe under WFH conditions. We examine the association between WFH and action controls. Based on a survey among employees in a large international corporation, we find that under WFH conditions the organization more intensively uses standardization and planning participation. We also examine the association between WFH and employee outcomes. The findings suggest that WFH is associated with more time employees spend in meetings and a higher job focus. Overall, the study adds to the literature by exploring the association between WFH and the use of management controls in organizations.