bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between hyperthyroidism and adverse obstetric and neonatal outcomes: A study of a population database including almost 17,000 women with hyperthyroidism
Authors: Hizkiyahu Ranit , Badeghiesh Ahmad , Baghlaf Haitham , Dahan Michael H. 
Published: March 2022

AbstractObjectiveLarge population‐based studies on maternal hyperthyroidism's effect on antepartum, intrapartum, and neonatal complications are few. Most of these studies were small or did not evaluate a broad scope of possible complications. Therefore, a large population‐based cohort study was conducted to study the associations between maternal hyperthyroidism and pregnancy and perinatal complications.DesignThis is a retrospective population‐based cohort study utilizing data from the Healthcare Cost and Utilization Project‐Nationwide Inpatient Sample over 11 years from 2004 to 2014.Patients16,984 deliveries to women with hyperthyroidism and 9,079,804 deliveries to mothers who did not suffer of hyperthyroidism.MethodsA cohort of all deliveries between 2004 and 2014 inclusively was created. Within this group, all deliveries to women with hyperthyroidism were the study group (n = 16,984) and the remaining deliveries were categorized as nonhyperthyroidism births and comprised the reference group (n = 9,079,804). The main outcome measures were pregnancy and perinatal complications.ResultsMaternal hyperthyroidism was associated with several pregnancy and perinatal complications, including increased risks of gestational hypertension (adjusted odds ratio [aOR]: 1.236, 95% confidence interval [CI]: 1.045–1.462, p = .013) and preeclampsia (aOR: 1.190, 95% CI: 1.006–1.408, p = .042). These patients are more likely to experience preterm premature rupture of membranes (aOR: 1.322, 95% CI: 1.007–1.735, p = .044), preterm delivery (aOR: 1.287 95% CI: 1.132–1.465, p < .001), placental previa (aOR: 1.527, 95% CI: 1.082–2.155, p = .016), and suffer from venous thromboembolism (aOR: 2.894, 95% CI: 1.293–6.475, p = .010).As for neonatal outcomes, small for gestational age and stillbirth were more likely to occur in the offspring of women with hyperthyroidism (aOR: 1.688, 95% CI: 1.437–1.984, p < .001 and aOR: 1.647, 95% CI: 1.109–2.447, p = .013, respectively).ConclusionsWomen with hyperthyroidism are more likely to experience pregnancy, delivery, and neonatal complications. We found an association between hyperthyroidism and hypertensive disorders, preterm delivery, and intrauterine fetal death.
Declining trends in birth prevalence and severity of singletons with cerebral palsy of prenatal or perinatal origin in Australia: A population‐based observational study
Authors: Smithers‐Sheedy Hayley , Waight Emma , Goldsmith Shona , Reid Sue , Gibson Catherine , Watson Linda , Auld Megan , Badawi Nadia , Webb Annabel , Diviney Leanne , Mcintyre Sarah ,   the Australian Cerebral Palsy Register Group
Published: March 2022

AimTo investigate temporal trends in birth prevalence, disability severity, and motor type for singletons with prenatal or perinatally acquired cerebral palsy (CP).MethodNumerator data, number of children with CP born a singleton between 1995 and 2014, confirmed at 5 years of age, were drawn from three state registers with population‐level ascertainment. Birth prevalence estimates and 95% confidence intervals (CI) were calculated per 1000 singleton live births for the three states combined, overall, by gestational age group, by dichotomized disability severity, and spastic laterality. Poisson regression models were used to analyse trends. Using data from all eight registers, trends in the proportional distribution of CP subtypes overall and stratified by gestational age were examined.ResultsBirth prevalence of CP declined from 1.8 (95% CI 1.6–2.0) in 1995 to 1996 to 1.2 (95% CI 1.1–1.4) in 2013 to 2014 (average 5% per 2‐year epoch, p < 0.001). Declines in birth prevalence were observed across all gestational age groups with the largest decline in children born at <28 weeks (average 8% per epoch, p < 0.001). Prevalence of moderate‐severe disability declined for children born at <28 and ≥37 weeks (average 11% and 7% per epoch respectively, p < 0.001). The proportions of bilateral spastic CP declined (p < 0.001) at <28 weeks (p = 0.014) and ≥37 weeks (p < 0.001). The proportion of children with dyskinesia increased (28–31 weeks: p = 0.021, 32–36 weeks: p = 0.001, and ≥37 weeks: p < 0.001).InterpretationBirth prevalence of CP and moderate‐severe disability (<28 and ≥37 weeks) declined in Australian singletons between 1995 and 2014, reflecting changes in prenatal and perinatal care over time.What this paper adds

Declines in birth prevalence of prenatal or perinatally acquired cerebral palsy were observed for singletons born in Australia between 1995 and 2014.

These declines were evident across all gestational age groups.

Declines in birth prevalence of moderate‐severe disability were observed for children born at <28 weeks and ≥37 weeks.
Future of kidney imaging: Functional magnetic resonance imaging and kidney disease progression
Authors: Copur Sidar , Yavuz Furkan , Sag Alan A. , Tuttle Kathherine R. , Kanbay Mehmet 
Published: March 2022

AbstractIntroductionChronic kidney disease (CKD) which is a common cause of death has an increasing trend, but there is no established approach for predicting CKD progression yet. Functional magnetic resonance imaging (fMRI) studies such as blood oxygenation level‐dependent MRI (BOLD‐MRI), diffusion‐weighted MRI (DWI‐MRI), diffusion‐tensor MRI (DTI‐MRI) and arterial spin labelling MRI (ASL‐MRI) are rising methods for the assessment of kidney functions in native and transplanted kidneys as well as the estimation of CKD progression.MethodsSystematic literature review was performed through the Embase (Elsevier), Cochrane Central Register of Controlled Trials (Wiley), PubMed/Medline and Web of Science databases, and studies investigating the role of fMRI methods assessing kidney functions in native and transplanted kidneys, as well as the value of fMRI methods to predict CKD progression, were included. Working mechanisms, advantages and limitations of the fMRI modalities were reviewed, and three studies investigating the role of fMRI studies in kidney functions were analysed.Results and conclusionBOLD‐MRI signal was found to be inversely correlated with annual eGFR change, and DWI/ADC (apparent diffusion coefficient map) values were shown to be correlated with annual eGFR decline. fMRI methods which are currently used for other systems can be utilized to provide more detailed information about kidney functions, and doctors should be ready to interpret kidney MRIs.
Anticipatory anxiety of seizures is associated with ictal emotional distress and amygdala onset seizures
Authors: Tarrada Alexis , Aron Olivier , Vignal Jean‐Pierre , Ertan Deniz , Maillard Louis , Hingray Coraline 
Published: March 2022

AbstractObjectiveAnxiety disorders are a frequent psychiatric condition in patients with epilepsy. Anticipatory anxiety of seizures (AAS) is described as a daily persistent fear or excessive worry of having a seizure. AAS seems to be related to “subjective ictal anxiety” reported by patients. The current study aimed to assess the association between objective ictal features and the presence of AAS.MethodsNinety‐one patients with drug‐resistant focal epilepsy underwent a standardized psychiatric assessment, specific for epilepsy, and presurgical long‐term video‐electroencephalography (EEG) or stereo‐EEG (SEEG). We compared seizure semiology and epilepsy features of patients with AAS (n = 41) to those of patients without AAS (n = 50). We analyzed emotional and motor behavior ictal signs as well as ictal consciousness. We further assessed amygdala ictal involvement in seizures recorded with SEEG (n = 28).ResultsAAS was significantly associated with the presence of ictal emotional distress; negative emotional behavior (p < .01) and negative emotion were explicitly reported to the examiner during recording (p = .015), regardless of the ictal level of consciousness. Among the patients recorded with SEEG, we found a significant involvement of amygdala within the seizure onset zone (p < .01) for patients with AAS.SignificanceHigher risk of developing AAS is associated with seizures expressing negative emotional symptoms, independently of ictal consciousness level. Persistent interictal fear of seizures might be viewed as the consequence of a reinforcement of the emotional networks secondary to amygdala involvement in seizures of temporal origin. Physicians should screen for AAS not only to assess the impact of epilepsy on daily life, but also as an interictal biomarker of ictal semiology and emotional network involvement at seizure onset.
The model of Tibetan thangka sales under blockchain technology
Authors: Fang Yuan 
Published: March 2022

AbstractIn order to improve the reliability of Tibetan Thangka sales channels, this paper combines blockchain technology to construct an intelligent model that can be used for Tibetan Thangka sales. This paper uses cryptographic encryption technology to encrypt the uploaded data to prevent Thangka producers or logistics turnover parties from tampering with Thangka‐related information, and uses the timestamp in blockchain technology to realize the traceability of Thangka‐related information. In addition, this paper uses the timestamp technology in the blockchain system to generate a traceable, query and supervised blockchain, which runs through the whole process of thangka from planting to selling. Finally, a sales model of Tibet Thangka based on blockchain technology is designed, and system performance analysis is carried out through simulation experiments. The experimental research results verify that the designed sales model has a certain effect.
Seasonal variation in the coupling of microbial activity and leaf litter decomposition in a boreal stream network
Authors: Bastias Elliot , Sponseller Ryan A. , Bundschuh Mirco , Jonsson Micael 
Published: March 2022

Abstract

Most stream networks are characterised by spatial and temporal variability in the physico‐chemical conditions that regulate microbial processing of particulate organic matter. How these patterns control the turnover of particulate organic matter via altered activity of leaf‐associated microbes has rarely been studied in high‐latitude landscapes, particularly throughout long (i.e., up to 6 months) ice‐ and snow‐covered periods.

We investigated development of fungal biomass, enzyme activity, microbial respiration, and birch leaf litter decomposition from autumn to early summer in 11 nested streams in a boreal catchment that encompass a gradient in wetland (mire) cover.

We observed relatively low variability in decomposition rates across the network, despite differences in key physical and chemical variables (e.g. temperature, pH, and dissolved organic carbon [DOC] concentrations) over time and space.

Microbial enzymatic activity and respiration were positively related to leaf litter decomposition rates during early stages of decomposition (i.e., up to c. 30% loss of initial ash‐free dry mass). Thereafter, variation in microbial activity and respiration was decoupled from leaf litter mass loss, as enzymatic activity and respiration instead became positively related to DOC concentrations and upstream mire (wetland) cover among streams.

Our results suggest that leaf‐associated microbes increase their reliance on external sources of energy over time. This switch in resource use was more evident in streams with higher DOC concentration, which in boreal landscapes is largely determined by mire cover. Hence, variation in DOC concentration, linked to landscape configuration, or from intensified land use and climate change, could affect how different carbon sources are used by stream microbial communities, with consequences for overall carbon cycling in boreal headwaters.
Past climate cooling promoted global dispersal of amphipods from Tian Shan montane lakes to circumboreal lakes
Authors: Hou Zhonge , Jin Pengyu , Liu Hongguang , Qiao Huijie , Sket Boris , Cannizzaro Andrew G. , Berg David J. , Li Shuqiang 
Published: March 2022

AbstractClimate changes have substantial impacts on the geographic distribution of montane lakes and evolutionary dynamics of cold‐adapted species. Past climate cooling is hypothesized to have promoted the dispersal of cold‐adapted species via montane lakes, while future climate warming is thought to constrain their distributions. We test this hypothesis by using phylogeographic analysis and niche modeling of the Holarctic crustacean Gammarus lacustris with global sampling comprised of 567 sequenced individuals and 3180 occurrence records. We found that the species arose in Tian Shan in Central Asia and dispersed into montane lakes along the Alps, Himalayas, Tibet, East Asia, and the North American Rocky Mountain ranges, with accelerated diversification rates outside Tian Shan. Climatically suitable regions for geographic lineages of G. lacustris were larger during cooling periods (LGM), but smaller during warming periods (Mid‐Holocene). In the future (2070) scenario, potential distributions in the Himalayas, North Tibet, South Tibet and North America are predicted to expand, whereas ranges in East Asia, Europe and Tian Shan will decline. Our results suggest that Mid‐Miocene‐to‐Pleistocene continuous cooling promoted multiple independent dispersal events out of Tian Shan due to increased availability of montane lakes via “budding” of lineages. Montane lakes are conduits through which cold‐adapted amphipods globally dispersed, dominating circumboreal lakes. However, future climate warming is likely to force organisms to shift upward in altitude and northward in latitude, leading to a future change in local populations. These findings highlight the importance of conservation of montane lakes, especially in the context of climate change.
Effect of kinematics on the torque/force generation, surface characteristics, and shaping ability of a nickel‐titanium rotary glide path instrument: An ex vivo study
Authors: Kyaw Moe S. , Ebihara Arata , Maki Keiichiro , Kimura Shunsuke , Nakatsukasa Taro , Htun Pyae H. , Thu Myint , Omori Satoshi , Okiji Takashi 
Published: March 2022

AbstractAimTo evaluate the effect of various rotational motions on the torque/force generation, surface wear, and shaping ability of the ProGlider glide path instrument (Dentsply Sirona).MethodologyMesiobuccal and mesiolingual canals of mandibular molars were selected based on the canal volume, length, angle of curvature (25°–40°), and radius of curvature (4–8 mm) after micro‐computed tomographic scanning. The samples were randomly assigned to four groups (n = 13, each) according to movement kinematics [continuous rotation (CR; 300 rpm), optimum torque reverse motion (OTR; 180° forward and 90° reverse when torque >0.4 N cm), time‐dependent reciprocal motion (TmR; 180° forward and 90° reverse), and optimal glide path motion (OGP; a combination of 90° forward, 90° reverse, 90° forward, and 120° reverse)]. Instrumentation was performed with an automated root canal instrument and torque/force analysing device. Maximum torque/force values, canal volume changes, and canal‐centring ratios at 1, 3, 5, and 7 mm were evaluated. Surface defects (pits, grooves, microcracks, blunt cutting edges, and disruption of cutting edges) and spiral distortion on the ProGlider instrument were scored at the tip and 5 mm short of the tip before and after five consecutive uses with scanning electron microscopy. The Kruskal–Wallis test followed by Dunn's post‐test with Bonferroni correction and Wilcoxon signed‐rank test were used to analyse the data (α = 0.05).ResultsOptimal glide path motion generated significantly less clockwise torque and greater upward force than other groups (p < .05). OGP resulted in significantly fewer surface defects than CR (p < .05). In OGP and CR, the tip exhibited more surface defects than 5 mm short of the tip (p < .05). CR resulted in greater volume changes than OGP and TmR (p < .05) and greater centring ratios (i.e., more deviation) than OGP at 1 mm and OTR at 3 mm (p < .05).ConclusionsUnder laboratory conditions using the ProGlider instrument, OGP generated significantly less clockwise torque and greater upward force than the other rotatory motions. OGP generated fewer superficial defects than CR, and the three modes of reciprocal rotation better maintained the apical curvature of root canals than CR with the ProGlider instrument.
In vivo Lesion Index (LSI) validation in percutaneous radiofrequency catheter ablation
Authors: Themistoclakis Sakis , Calzolari Vittorio , De Mattia Luca , China Paolo , Dello Russo Antonio , Fassini Gaetano , Casella Michela , Caporaso Igor , Indiani Stefano , Addis Alessandro , Basso Cristina , Della Barbera Mila , Thiene Gaetano , Tondo Claudio 
Published: March 2022

AbstractIntroductionLesion Index (LSI) has been developed to predict lesion efficacy during radiofrequency (RF) catheter ablation. However, its value in predicting lesions size has still to be established. The aim of our study was to assess the lesions size reproducibility for prespecified values of LSI reached during RF delivery in an in vivo beating heart.MethodsAblation lesions were created with different values of LSI in seven domestic pigs by means of a contact force‐sensing catheter (TactiCathTM, Abbott). Lesions were identified during RF delivery by means of a three‐dimensional mapping system (EnSiteTMPrecision, Abbott) and measured after heart explantation. Histology was carried out after gross examination on the first three lesions to confirm the accuracy of the macroscopic evaluation.ResultsA total of 64 myocardial lesions were created. Thirty‐nine lesions were excluded from the analysis for the following reasons: histological confirmation of macroscopic lesion measurement (n = 3), transmurality (n = 24), unfavorable anatomic position (n = 10), not macroscopically identifiable (n = 2). In a final set of 25 nontransmural lesions, injury width and depth were, respectively, 4.6 ± 0.6 and 2.6 ± 0.8 mm for LSI = 4, 7.3 ± 0.8 and 4.7 ± 0.6 mm for LSI = 5, and 8.6 ± 1.2 and 7.2 ± 1.1 mm for LSI = 6. A strong linear correlation was observed between LSI and lesion width (r = .87,p < .00001) and depth (r = .89,p < .00001). Multiple linear regression analysis identified LSI as the only ablation parameter that significantly predicted lesion width (p < .001) and depth (p < .001).ConclusionIn our in vivo study, LSI proved highly predictive of lesion size and depth.
The first detection of betanodavirus reassortant genotype (RGNNV/SJNNV) isolated from gilthead sea bream (Sparus aurata) in the Turkish coastlines: The importance of screening and monitoring studies for identifying the source of the infection
Authors: Kaplan Murat , Pekmez Kemal , Cagirgan Abdurrahman Anil , Arslan Fatih , Özkan Buket , Kalaycı Gülnur 
Published: March 2022

AbstractViral nervous necrosis (VNN) is now endemic in the Mediterranean basin and the RGNNV genotype betanodavirus has caused frequent epidemics in European sea bass for a long time. Unexpected and increasing VNN epidemics have been reported in gilthead sea bream (GSB) farms in the last few years, from which the RGNNV/SJNNV genotype has been mostly isolated. The aim of this study was to perform a molecular characterization of the betanodavirus isolated from GSB (weighing 90–100 g) in a marine fish farm in the Aegean Sea and also, as an early warning exercise, to investigate the presence/absence of the virus in associated nearby farms (n:20) and in hatcheries (n:3). No virus was detected in any of the nearby farms or two hatcheries. However, in one hatchery, betanodavirus was detected in a 160‐day‐old GSB. The identified betanodavirus was genotyped as reassortant RGNNV/SJNNV and was phylogenetically related to the virus detected in the farm located in the Aegean sea. There have been multiple detections of the RGNNV genotype in Turkish coastal waters; however, the RGNNV/SJNNV genotype has been detected for the first time and it should be an early warning to focus attention on betanodaviruses in Turkish aquaculture.
Effects of nonthermal physical processing technologies on functional, structural properties and digestibility of food protein: A review
Authors: Pan Jiayin , Zhang Zhaoli , Mintah Benjamin Kumah , Xu Haining , Dabbour Mokhtar , Cheng Yu , Dai Chunhua , He Ronghai , Ma Haile 
Published: March 2022

AbstractThis review assesses the nonthermal physical processing technologies for protein modification. The review also discusses the structural, functional, and digestibility attributes of protein following nonthermal physical processing. Applications of ultrasonication, ultrahigh pressure, and pulsed electric field (PEF) can induce the conformational changes of protein via the creation of free radicals and/or larger/smaller protein molecules, damaging the primary, secondary, tertiary, and quaternary structure of protein, and thus influence the functional properties. Some key achievements in using nonthermal physical technologies to process protein‐rich foods include improved enzymatic hydrolysis, solubility, emulsification, foaming, gelatinization, digestion properties, and reduced allergenicity. Therefore, nonthermal physical technologies are useful methods to modify food protein structure and functionality for the food industry.Practical ApplicationThe demand for protein with desirable functional properties and nutritional value makes it imperative to find suitable processing technologies that could conserve or yield high quality proteins from both conventional and nonconventional sources. Since thermal processing (including microwave, radiofrequency heating, etc.) could possibly reduce the quality attributes of proteins, many researchers have focused their investigations on nonthermal physical processing to improve the functional properties of proteins. To this regard, this review discusses nonthermal techniques, including ultrasonication, high‐pressure processing, PEFs, cold plasma, and ultraviolet.
Extraction and modification of Achachairu's seed (Garcinia humilis) starch using high‐intensity low‐frequency ultrasound
Authors: Almeida Raphael Lucas Jacinto , Santos Newton Carlos , dos Santos Pereira Tamires , Monteiro Shênia Santos , da Silva Lucas Rodolfo Inácio , da Silva Eduardo Raphael , Alves Israel Luna , dos Santos Everaldo Silvino 
Published: March 2022

AbstractThis study aimed to evaluate the effect of ultrasound high‐intensity low‐frequency on the extraction and modification of the characteristics of the starch from achachairu seeds. The ultrasonic treatment was applied to the seeds and starch at the power of 300 W at 25.48 kW/m2 and 25 kHz, with different exposure times (T1‐10, T2‐30, and T3‐60 min). The modified starches (T1, T2, and T3) were characterized considering physical–chemical, physical, morphological, thermal, structural, and viscoamylographic properties. The starch shelf life was evaluated for absorption the water and oil and syneresis index over 35 days. The results revealed that ultrasound‐assisted extraction achieved higher yield (42.05%) and higher starch content (74.94 g/100 g) creating pores on the surface of the granules which reduced crystallinity by 16.92%. However, the crystal structure for sample A + V, after 60 min of exposure, was maintained. The clarity parameter of the starch paste decreased from 32.63% to 27.01% due to the exposure time. Starch (T3) presents greater stability in water absorption, oil and syneresis index (during storage) and is considered a thickening and emulsifying agent. Ultrasonic treatment can optimistically modify achachairu seed starch properties, making it a promising technology, both for starch extraction and modification.Practical applicationsUltrasound‐assisted starch processing can significantly alter the starch properties of achachairu seeds. In this work, new information about the extraction and modification of starch using ultrasound as pretreatment are obtained. Furthermore, the results indicate possibilities of increasing the commercial value of the starch from the seeds of achachairu, considering the range of uses of starches for food and nonfood purposes.