bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimally Invasive Approaches Are Safe for Concomitant Mitral and Tricuspid Valve Surgery
Authors: Strobel Raymond J. , Hawkins Robert B. , Mehaffey J. Hunter , Rotar Evan P. , Yount Kenan W. , Teman Nicholas R. , Ailawadi Gorav 
Published: October 2022

Objective: The need for concomitant tricuspid surgery during mitral valve surgery is associated with higher operative risk. We hypothesized that concomitant tricuspid surgery through a minimally invasive thoracotomy (MICS) is associated with noninferior risk compared with a sternotomy. Methods: All patients undergoing mitral valve surgery at a single institution (2010 to 2020) were evaluated. After excluding endocarditis, emergent operations, and concomitant aortic valve or coronary artery bypass grafting procedures, patients were stratified by MICS versus sternotomy. Multivariable logistic regression assessed the risk-adjusted association between concomitant tricuspid valve procedure and Society of Thoracic Surgeons major morbidity or mortality. An interaction term evaluated the impact of approach on concomitant tricuspid surgery. Results: A total of 772 patients underwent mitral valve surgery, including 138 (17.9%) with concomitant tricuspid valve operation. Of the total cohort, 243 patients (31.5%) underwent the MICS approach. Concomitant tricuspid operation was performed in 104 sternotomy patients (19.7%) compared with 34 MICS patients (14.0%, P = 0.056). After risk adjustment, patients who underwent concomitant tricuspid valve surgery via sternotomy had nearly 2 times greater odds of morbidity and mortality relative to those undergoing isolated mitral surgery via sternotomy (adjOR = 1.86, P = 0.049), while patients who underwent concomitant tricuspid surgery via the MICS approach had no increased risk of the composite outcome (adjOR = 0.66, P = 0.543), relative to isolated mitral surgery via MICS approach. Conclusions: Concomitant tricuspid surgery at the time of mitral valve surgery carries additional risk in a broad patient population. A minimally invasive approach appears to be safe for selected patients requiring concomitant tricuspid valve surgery.
Smoking cessation prior to total shoulder arthroplasty: A systematic review of outcomes and complications
Authors: Kamma Sai A , Pathapati Rajeev K , Somerson Jeremy S 
Published: October 2022

Background We conducted a review of current literature to examine the effects of smoking and smoking cessation on shoulder arthroplasty surgery. Methods A literature search was performed using the search terms “shoulder arthroplasty AND [smoke OR smoking OR tobacco OR nicotine].” Studies included English-language clinical outcomes studies on anatomic total shoulder arthroplasty (TSA), reverse TSA, and partial shoulder arthroplasty with evidence levels 1 through 4. Descriptive statistics calculated in the included studies were used during the analysis. Categorical variables were reported as proportions, while continuous variables were reported as means with minimum to maximum absolute ranges. Results Twenty-four studies were included and analyzed. Following TSA, patients who quit smoking at least 1 month preoperatively had improved outcomes compared to current smokers. Current smokers had statistically significant higher pain scores or opioid use. Five studies found increased rates of revision surgery in smokers. Smokers were significantly ( p < 0.05) more likely to have increased rates of surgical, wound, superficial, and deep surgical site complications. Discussion Former smokers had lower complication rates and visual analog scale scores when compared to current users. A period of four weeks or more of preoperative smoking cessation is recommended. Level of Evidence Level III, Systematic Review.
Seeing Is Believing: Using Eye-Tracking Devices in Environmental Research
Authors: Lu Zhipeng , Pesarakli Homa 
Published: October 2022

Objectives: This article aims to provide methodological guidance for research that uses eye-tracking devices (ETDs) to study environment and behavior relationships. Background: Vision is an important human sense through which people acquire a large amount of environmental information. ETDs are tools for detecting eye/gaze behaviors, facilitating better understanding about how people collect visual information and how such information is related to emotions and psychological states. However, there is a lack of guidance for the application of ETDs to environment and behavior studies. Methods: A literature review was conducted on articles reporting empirical studies that used ETDs. The data were extracted and compiled, including information such as research questions, research design, types of ETDs, variables measured, types of physical environment (or visual stimuli), stimuli durations, data analysis methods, and so on. Results: Fifty articles were identified. The main research topics were related to urban and landscape environments, and architecture and interior spaces. Most of the research designs were experimental or quasi-experimental designs, with a few cross-sectional studies. The majority types of ETDs were screen-based ETDs, followed by mobile ETDs (glasses). Main variables were gaze fixations, fixation durations, and scan paths. Typical types of stimuli included images, videos, virtual reality, and real environments and/or objects. Conclusions: Guidance for eye-tracking research on environment and behavior was developed based on the literature review results, to provide direction for determining research questions, selecting appropriate research designs, establishing participant inclusion and/or excluding criteria, collecting and analyzing data, and interpreting research results.
Remote patient monitoring of central retinal function with MACUSTAT®: A multi-modal macular function scan
Authors: Chen Earnest , Mills Michael , Gallagher Tara , Ianchulev Sean , Habash Ranya , Gentile Ronald C ,   (The Macustat Study Group)
Published: October 2022

Introduction There is significant unmet need for patient-centric remote monitoring of visual function for chronic retinal diseases, as demonstrated by the COVID-19 pandemic. The Macustat® central retinal function scan is a novel cloud-based digital health application for remote monitoring. The aim of this study is to assess the efficacy of the Macustat® compared to traditional in-office retinal evaluations. Materials and methods Patients with underlying macular pathology underwent office-based retinal and visual acuity examinations and OCT macula imaging followed by remote tele-monitoring assessment with the Macustat. Central visual function was assessed with the multi-modal Macustat test using dynamic virtual Amsler grid testing, hyperacuity perimetry and visual acuity testing. The results were compared to the findings of the in-office comprehensive retina exam and OCT evaluation. Results The foveal acuity potential registered with the Macustat test showed high correlation with the office Snellen acuity potential 96% of eyes registered Macustat acuity within 0.2 LogMAR of office acuity measurement. In Wet AMD eyes with CNV pathology documented on OCT, the Macustat foveal function scan showed a corresponding abnormality in 89% of any CNV eyes and 100% of all visually significant CNV. In normal eyes without any visually significant edema or CNV, more than 92% showed corresponding normal retinal function scan. Conclusion The Macustat demonstrates high concordance with clinical findings using traditional diagnostic devices. Home monitoring with the Macustat® may offer complementary clinical utility as a telehealth tool for the assessment of visual acuity and macular function in patients at high risk for macular disease.
Increased future liver function after modified associating liver partition and portal vein ligation/embolization for staged hepatectomy
Authors: Maruyama Mitsunari , Yoshizako Takeshi , Yoshida Rika , Nakamura Megumi , Tajima Yoshitsugu , Kitagaki Hajime 
Published: October 2022

Background The increasing ratio of functional future liver remnant (functional %FLR) after modified associating liver partition and portal vein ligation/embolization for staged hepatectomy (modified-ALPPS) compared with portal vein embolization (PVE) has not been comprehensively evaluated. Purpose To compare the increasing ratio of functional %FLR between modified-ALPPS and PVE via technetium-99 m-galactosyl human serum albumin single-photon emission computed tomography (99mTc-GSA SPECT/CT) fusion imaging. Material and Methods Seven and six patients underwent modified-ALPPS (modified-ALPPS group) and PVE (PVE group) from 2015 to 2019. The functional %FLR on 99 mTc-GSA SPECT/CT fusion imaging was assessed before and 1 week (modified-ALPPS group) and 3 weeks (PVE group) after each procedure. The increasing ratio of functional %FLR (functional %FLR ratio) was calculated and compared between the two groups. Moreover, the hypertrophy ratio of future liver remnant volume (FLRV ratio) and atrophy ratio of embolized liver volume (.ELV ratio) were evaluated. Results The mean functional %FLR ratios of the modified-ALPPS group (1.47 ± 0.15) and the PVE group (1.49 ± 0.20) were comparable ( p > .05). The median FLRV ratio of modified-ALPPS group (1.48) was higher than that of the PVE group (1.16), the median ELV ratio of the PVE group (0.81) was lower than that of the modified-ALPPS group (0.94), and the results significantly differed between the two groups ( p < .05). Conclusion The increasing ratio of functional %FLR was comparable between modified-ALPPS and PVE. Compared with PVE, ALPPS was associated with a higher hypertrophy rate of the remnant liver but a lower atrophy rate of the embolized liver.
Users’ perceptions of the “My Medicine” mobile app usability
Authors: Irnawati  , Laksana Feri Febria , Hardini Deisy Sri , Lufianti Anita , Sulistyanto Benny Arief , Sansuwito Tukimin bin , Muliani Rizki , Hadiyanto Hendri , Lusiani Milawati , Hayati Sri , Amir Mayasyanti Dewi , Armayani  , Desriva Nia , Mulyani Sri , Anggraini Novita Ana , Ambarika Rahmania , Azizah Fidrotin , Maidartati  , Poddar Ruma 
Published: October 2022

Introduction: One of the causes of health problems is the use of drugs irrationally, which can result in therapy becoming less effective and inefficient. According to World Health Organization (WHO), more than 50% of the world’s drugs are prescribed and used improperly. People still lack information about drugs, how to use drugs and how to get drugs. My Medicine is a drug data information system, how to use drugs, and map locations of pharmacies that sell drugs. This study aims to evaluate the user perception of the use of my medicine. Materials and methods: The method in this study was a quantitative study with a cross-sectional approach. One hundred twenty respondents were included in this study involving communities in Pekalongan district by using univariate analysis. Results: The result was 82% of the respondents explained that the performance or interface user of the My Medicine App was very good and the language was easy to understand, 82% of the respondents said that the information on the My Medicine App is needed daily, 84% of the respondents said that My Medicine App easy to access from the mobile phone, 80% of the respondents explained the data provided in the My Medicine App was accurate and as what they are expected. Conclusion: The conclusion is My Medicine App has a very good performance, the language is easy to understand, the information is needed daily, the app is easy to access through a mobile phone. The data presented in the My Medicine Application is accurate, and by user expectations.
The Effects of Selected Mouthwashes on the Surface Microhardness of a Single-shade Universal Resin Composite: In Vitro Study
Authors: Al-Saud Loulwa M. , Alolyet Lina M. , Alenezi Dhayah S. 
Published: October 2022

Aim: To investigate the effects of selected alcohol-free mouthwashes with different formulations (zinc-hydroxyapatite, hydrogen peroxide, and sodium fluoride) on the surface microhardness of a single-shade universal resin composite. Materials and Methods: Forty disc-shaped specimens (8 × 2 mm) from the universal resin composite (Omnichroma®), and a nano-hybrid composite (Tetric® N-Ceram) were prepared. After polymerization, baseline surface microhardness values were recorded using Vickers microhardness tester. The samples from each material were randomly assigned to 4 groups ( n = 10) and immersed in 20 ml of the mouthwashes: Biorepair®, Listerine®, Colgate® Optic White, and distilled water (control). The samples were kept in the immersion solutions for 24 hours, and post-immersion microhardness values were recorded. Data were analyzed with one-way ANOVA and paired sample t-tests at p < .05. Results: Significant reduction in microhardness was observed in all resin composite groups after immersion in the mouthwashes compared to baseline values ( p < .0001). The highest microhardness reduction in Omnichroma® group was observed after immersion in Colgate® Optic White; and Tetric® N-Ceram group after immersion in Listerine® mouthwash. For both materials, the least reduction in microhardness was observed after immersion in Biorepair®. Microhardness values for Omnichroma were significantly higher than Tetric® N-Ceram ( p < .0001). However, Omnichroma exhibited a significantly greater reduction in microhardness after immersion in the tested mouthwashes. Conclusion: In vitro simulated use of the investigated mouthwashes negatively affected the surface microhardness of both tested resin composites. The observed effects were both mouthwash and material dependent.
How Can Resilience Create and Build Market Value?
Authors: Swaminathan Raj 
Published: October 2022

Resilience of an organization is increasingly being perceived as the key factor that enables businesses to bounce back from the inevitable ‘curved balls’ posed by big challenges such as economic, environmental and health impacts (as with the current pandemic), technological discontinuities, regulatory changes, geopolitical shocks, industry de-verticalization and dis-intermediation, sudden shifts in consumer tastes and many/new non-traditional competitors who undermine the disadvantages of incumbency. Organizational resilience defined: Key definitions in the classical literature specify it as a dynamic capability and ‘ability to effectively absorb, develop situation-specific responses to, and ultimately engage in transformative activities to capitalize on disruptive surprises that potentially threaten organization survival’ ( Lengnick-Hall et al., 2011 ). This article attempts to study how resilience can be built in organizations and how it generates market/customer value for businesses in the long haul.
Septoplasty Training During the COVID‐19 Era: Development and Validation of a Novel Low‐Cost Simulation Model
Authors: Rosenbaum Andrés , Faba Gabriel , Varas Julián , Andrade Tomás 
Published: October 2022

ObjectiveIn a context of increasingly limited surgical exposition, enhanced by the coronavirus disease 2019 (COVID‐19) pandemic context, the objective of this article is to explain the development of a novel low‐cost and simple replication animal‐based septoplasty training model for otolaryngology residents, to assess its face and construct validity, and to validate a specific rating scale for each task.Study DesignExperimental study.SettingSurgical simulation laboratory.MethodsSeptoplasty experts divided the procedure into key tasks. A simulator model to perform tasks was developed using pig ears to imitate human nasal septum cartilage, and a Specific Rating Scale was constructed. Trainees and faculty performed all tasks in the model. The participants were videotaped, and operative time, hand movements, and path length were recorded using a motion sensor device. Two blinded experts evaluated the videos with Global and Specific Rating Scales. All participants answered a satisfaction survey.ResultsFifteen subjects were recruited (7 trainees and 8 faculty). Significantly higher Global Rating Scale score, shorter operative time and path length, and fewer hand movements were observed in the faculty group. The satisfaction survey showed high applicability to a real scenario (mean score of 4.6 out of 5). Specific Rating Scale showed construct and concurrent validity and high reliability.ConclusionThis simulation model and its specific rating scale can be accurately used as a validated surgical assessment tool for endonasal septoplasty skills. Its low cost and simple replicability make it a potentially useful tool in any otolaryngology surgical training program.
Hotspots sequences of gyrA, gyrB, parC, and parE genes encoded for fluoroquinolones resistance from local Salmonella Typhi strains in Jakarta
Authors: Nathania Ignes , Nainggolan Ita M. , Yasmon Andi , Nusatia Angela Ch. M. , Tjoa Enty , Gunardi Wani D. , Moehario Lucky H. 
Published: October 2022

Abstract
Background
Infection of Salmonella enterica subsp. enterica serovar Typhi is the primary etiology of typhoid fever globally and is common in many developing countries, especially those with dense populations and poor environmental sanitation. Antibiotic fluoroquinolones were used for the treatment in the 1980s due to the resistance to the first-line antibiotics. However, many cases of treatment failure of fluoroquinolones in typhoidal patients have been reported from numerous countries in Asia, Europe, Africa, and America. Mutations in quinolone resistance determining regions (QRDR) genes, gyrA, gyrB, parC, and parE, are found in fluoroquinolone-resistant Salmonella Typhi. Contrast reports came from the S. Typhi isolates in Indonesia, mainly Jakarta and the surroundings, obtained from patients with typhoid fever, with good sensitivity to the fluoroquinolones, i.e., nalidixic acid, ciprofloxacin, moxifloxacin, and levofloxacin. The present study, therefore, aimed to identify the hotspot sequences of gyrA, gyrB, parC, and parE genes of the local S. Typhi strains based on their susceptibility to fluoroquinolones from patients with typhoid fever in Jakarta and its satellite cities.

Results
A total of 28 isolates were identified as S. Typhi. All isolates were susceptible to nalidixic acid, levofloxacin, and moxifloxacin. Twenty-seven isolates (96.4%) were susceptible to ciprofloxacin, with one isolate (3.6%) being intermediate. The hotspot sequences of gyrA, gyrB, parC, and parE genes from all isolates were identical to the fluoroquinolone-sensitive reference sequence Salmonella enterica subsp. enterica serovar Typhi Ty2 (NCBI GenBank AE014613.1), including the isolate with intermediate susceptibility. The mutation was not found, and amino acid deduced from all hotspots in susceptible and intermediate isolates showed no replacement in all reported codons.

Conclusions
This study showed that the local S. Typhi strains from Jakarta and surroundings were susceptible to fluoroquinolones (nalidixic acid, ciprofloxacin, levofloxacin, and moxifloxacin), and the hotspot sequences of the gyrA, gyrB, parC, and parE genes were all identical to the reference sequence. Thus, the hotspot sequences of the gyrA, gyrB, parC, and parE genes seemingly were conserved in Jakarta’s local S. Typhi strains and could be considered wild type. The phenotypic susceptibility was consistent with the genotypic characteristic without non-synonymous mutations associated with drug resistance.
A disease progression model estimating the benefit of tolvaptan on time to end-stage renal disease for patients with rapidly progressing autosomal dominant polycystic kidney disease
Authors: Mader Gregory , Mladsi Deirdre , Sanon Myrlene , Purser Molly , Barnett Christine L. , Oberdhan Dorothee , Watnick Terry , Seliger Stephen 
Published: October 2022

Abstract
Background
Tolvaptan was approved in the United States in 2018 for patients with autosomal dominant polycystic kidney disease (ADPKD) at risk of rapid progression as assessed in a 3-year phase 3 clinical trial (TEMPO 3:4). An extension study (TEMPO 4:4) showed continued delay in progression at 2 years, and a trial in patients with later-stage disease (REPRISE) provided confirmatory evidence of efficacy. Given the relatively shorter-term duration of the clinical trials, estimating the longer-term benefit associated with tolvaptan via extrapolation of the treatment effect is an important undertaking.

Methods
A model was developed to simulate a cohort of patients with ADPKD at risk of rapid progression and predict their long-term outcomes using an algorithm organized around the Mayo Risk Classification system, which has five subclasses (1A through 1E) based on estimated kidney growth rates. The model base-case population represents 1280 patients enrolled in TEMPO 3:4 beginning in chronic kidney disease (CKD) stages G1, G2, and G3 across Mayo subclasses 1C, 1D, and 1E. The algorithm was used to predict longer-term natural history health outcomes. The estimated treatment effect of tolvaptan from TEMPO 3:4 was applied to the natural history to predict the longer-term treatment benefit of tolvaptan. For the cohort, analyzed once reflecting natural history and once assuming treatment with tolvaptan, the model estimated lifetime progression through CKD stages, end-stage renal disease (ESRD), and death.

Results
When treated with tolvaptan, the model cohort was predicted to experience a 3.1-year delay of ESRD (95% confidence interval: 1.8 to 4.4), approximately a 23% improvement over the estimated 13.7 years for patients not receiving tolvaptan. Patients beginning tolvaptan treatment in CKD stages G1, G2, and G3 were predicted to experience estimated delays of ESRD, compared with patients not receiving tolvaptan, of 3.8 years (21% improvement), 3.0 years (24% improvement), and 2.1 years (28% improvement), respectively.

Conclusions
The model estimated that patients treated with tolvaptan versus no treatment spent more time in earlier CKD stages and had later onset of ESRD. Findings highlight the potential long-term value of early intervention with tolvaptan in patients at risk of rapid ADPKD progression.