bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart Mechanoluminescent Phosphors: A Review of Strontium‐Aluminate‐Based Materials, Properties, and Their Advanced Application Technologies
Authors: Huang Zefeng , Chen Bing , Ren Biyun , Tu Dong , Wang Zhaofeng , Wang Chunfeng , Zheng Yuantian , Li Xu , Wang Dong , Ren Zhanbing , Qu Sicen , Chen Zhuyang , Xu Chen , Fu Yu , Peng Dengfeng 
Published: November 2022

AbstractMechanoluminescence, a smart luminescence phenomenon in which light energy is directly produced by a mechanical force, has recently received significant attention because of its important applications in fields such as visible strain sensing and structural health monitoring. Up to present, hundreds of inorganic and organic mechanoluminescent smart materials have been discovered and studied. Among them, strontium‐aluminate‐based materials are an important class of inorganic mechanoluminescent materials for fundamental research and practical applications attributed to their extremely low force/pressure threshold of mechanoluminescence, efficient photoluminescence, persistent afterglow, and a relatively low synthesis cost. This paper presents a systematic and comprehensive review of strontium‐aluminate‐based luminescent materials’ mechanoluminescence phenomena, mechanisms, material synthesis techniques, and related applications. Besides of summarizing the early and the latest research on this material system, an outlook is provided on its environmental, energy issue and future applications in smart wearable devices, advanced energy‐saving lighting and displays.
Harvesting PdH Employing Pd Nano Icosahedrons via High Pressure
Authors: Shi Kun , Huo Zihao , Liang Tianxiao , Sui Yongming , Liu Chuang , Shu Haiyun , Wang Lin , Duan Defang , Zou Bo 
Published: November 2022

AbstractPalladium hydrides (PdHx) have important applications in hydrogen storage, catalysis, and superconductivity. Because of the unique electron subshell structure of Pd, quenching PdHx materials with more than 0.706 hydrogen stoichiometry remains challenging. Here, the 1:1 stoichiometric PdH ( is successfully synthesized using Pd nano icosahedrons as a starting material via high‐pressure cold‐forging at 0.2 GPa. The synthetic initial pressure is reduced by at least one order of magnitude relative to the bulk Pd precursors. Furthermore, PdH is quenched at ambient conditions after being laser heated ≈2000 K under ≈30 GPa. Corresponding ab initio calculations demonstrate that the high potential barrier of the facets (111) restricts hydrogen atoms' diffusion, preventing hydrogen atoms from combining to generate H2. This study paves the way for the high‐pressure synthesis of metal hydrides with promising potential applications.
High Energy Storage Density in Nd(Zn2/3Nb1/3)O3‐Doped BiFeO3–BaTiO3 Ceramics
Authors: Li Wen‐Yi , Zhou Di , Li Da , Guo Yan , Zhao Wei‐Chen , Pang Li‐Xia , Sun Shi‐Kuan 
Published: November 2022

AbstractLead‐free ceramics with high recoverable energy density (Wrec) and energy storage efficiency (η) are attractive for advanced pulsed power capacitors to enable greater miniaturization and integration. In this work, a series of perovskite structured (1‐x)(Bi0.6Ba0.4)(Fe0.6Ti0.4)O3−xNd(Zn2/3Nb1/3)O3 (BF‐BT‐NZN) ceramics with high energy storage density through the solid‐state reaction method are successfully prepared, and the breakdown strength (Eb) and energy storage density are further improved by a membrane rolling process. The highest energy densities of the 0.94(BF‐BT)−0.06NZN ceramics are Wrec ≈ 5.6 J cm−3 and η ≈ 82.9%, which are due to the enhanced breakdown field intensity (BDS ≈ 400 kV cm−1) and the maximum polarization (Pmax≈ 38 µC cm−2). These results indicate that (1−x)(Bi0.6Ba0.4) (Fe0.6Ti0.4)O3−xNd(Zn2/3Nb1/3)O3 ceramics are high‐efficiency lead‐free materials for potential application in high‐energy‐storage capacitors.
The developmental trajectories of the behavioral phenotype and neuropsychiatric functioning in Cornelia de Lange and Rubinstein Taybi syndromes: A longitudinal study
Authors: Ajmone Paola Francesca , Giani Ludovica , Allegri Beatrice , Michelini Giovanni , Dall'Ara Francesca , Rigamonti Claudia , Monti Federico , Vizziello Paola Giovanna , Selicorni Angelo , Milani Donatella , Scaini Simona , Costantino Antonella 
Published: November 2022

AbstractSeveral changes in the behavioral phenotype arise with the growth of children affected by Cornelia de Lange Syndrome (CdLS) and Rubinstein‐Taybi Syndrome (RSTS). However, previous research relied on a cross‐sectional study design turning into age‐related comparisons of different syndromic cohorts to explore age‐dependent changes. We aim to outline the variating pathways of the neuropsychiatric functioning across the lifespan in CdLS and RSTS, through the setting up of a longitudinal study design. The sample included 14 patients with CdLS and 15 with RSTS. The assessments were carried out in two different timepoints. Our findings highlight that the cognitive profile of CdLS is subjected to a worsening trend with decreasing Intellectual Quotient (IQ) scores from T0 to T1, whereas RSTS shows a stable IQ over time. Patients affected by RSTS show greater improvements compared to CdLS in communication, daily living skills, social abilities, and motor skills across the lifespan. Both syndromes report an upward trend in behavioral and emotional difficulties even if CdLS exhibit a significant and major deterioration compared to individuals with RSTS. Being aware of the early dysfunctional patterns which might pave the way for later neuropsychiatric impairments is the first step for planning preventive interventions.
Flexible strain sensors with high sensitivity and large working range prepared from biaxially stretched carbon nanotubes/polyolefin elastomer nanocomposites
Authors: Xiang Dong , Chen Xiaoyu , Li Jiayi , Wu Yuanpeng , Zhao Chunxia , Li Hui , Li Zhenyu , Wang Li , Wang Ping , Li Yuntao , Wang Junjie 
Published: November 2022

AbstractFlexible strain sensors are a new generation of flexible and stretchable electronic devices that attracted increasing attention due to their practical applications in many fields. However, maintaining a wide detectable strain range while improving the sensitivity of flexible strain sensors remains challenging. In this study, flexible strain sensors with a large working range based on biaxially stretched carbon nanotubes (CNTs)/polyolefin elastomer (POE) nanocomposites were fabricated. Biaxial stretching was demonstrated to enhance the uniform dispersion and orientation of CNTs, thereby improving the performance of sensors. The optimal stretching ratios (SRs) of nanocomposites were investigated and the data revealed an increment in the sensitivity of sensors with SRs, while the working range first increased after biaxial stretching and decreased at higher SRs. Compared to the 9 wt% CNT/POE‐1.0 sensor with a gauge factor (GF) value of 2.37 and a detectable range of 0.5%–230%, the CNT/POE‐2.0 sensor exhibited an enhanced sensitivity (GF = 3935.12) coupled with a wider detectable range (0.5%–710%) and better stability. Besides, CNT/POE‐2.0 sensor also achieved the monitoring of head movements, mouth opening, facial expression, and physiological signals, showing a potential for use in wearable electronic products.
Synthesis and biological evaluation of new quinoline‐4‐carboxylic acid‐chalcone hybrids as dihydroorotate dehydrogenase inhibitors
Authors: Petrović Milena M. , Roschger Cornelia , Lang Kevin , Zierer Andreas , Mladenović Milan , Trifunović Snežana , Mandić Boris , Joksović Milan D. 
Published: November 2022

AbstractFourteen novel quinoline‐4‐carboxylic acid‐chalcone hybrids were obtained via Claisen–Schmidt condensation and evaluated as potential human dihydroorotate dehydrogenase (hDHODH) inhibitors. The ketone precursor 2 was synthesized by the Pfitzinger reaction and used for further derivatization at position 3 of the quinoline ring for the first time. Six compounds showed better hDHODH inhibitory activity than the reference drug leflunomide, with IC50 values ranging from 0.12 to 0.58 μM. The bioactive conformations of the compounds within hDHODH were resolved by means of molecular docking, revealing their tendency to occupy the narrow tunnel of hDHODH within the N‐terminus and to prevent ubiquinone as the second cofactor from easily approaching the flavin mononucleotide as a cofactor for the redox reaction within the redox site. The results of the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay revealed that 4d and 4h demonstrated the highest cytotoxic activity against the A375 cell line, with IC50 values of 5.0 and 6.8 µM, respectively. The lipophilicity of the synthesized hybrids was obtained experimentally and expressed as logD7.4 values at physiologicalpH while the solubility assay was conducted to define physicochemical characteristics influencing the ADMET properties.
Recent updates on 1,2,3‐, 1,2,4‐, and 1,3,5‐triazine hybrids (2017–present): The anticancer activity, structure–activity relationships, and mechanisms of action
Authors: Dong Gaoli , Jiang Yingchun , Zhang Feng , Zhu Fengyun , Liu Junna , Xu Zhi 
Published: November 2022

AbstractCancer is one of the leading causes of death across the world, and the prevalence and mortality rates of cancer will continue to grow. Chemotherapeutics play a critical role in cancer therapy, but drug resistance and side effects are major hurdles to effective treatment, evoking an immediate need for the discovery of new anticancer agents. Triazines including 1,2,3‐, 1,2,4‐, and 1,3,5‐triazine have occupied a propitious place in drug design and development due to their excellent pharmacological profiles. Mechanistically, triazine derivatives could interfere with various signaling pathways to induce cancer cell death. Hence, triazine derivatives possess potential in vitro and in vivo efficacy against diverse cancers. In particular, triazine hybrids are able to overcome drug resistance and reduce side effects. Moreover, several triazine hybrids such as brivanib (indole‐containing pyrrolo[2,1‐f][1,2,4]triazine), gedatolisib (1,3,5‐triazine‐urea hybrid), and enasidenib (1,3,5‐triazine‐pyridine hybrid) have already been available in the market. Accordingly, triazine hybrids are useful scaffolds for the discovery of novel anticancer chemotherapeutics. This review focuses on the anticancer activity of 1,2,3‐, 1,2,4‐, and 1,3,5‐triazine hybrids, together with the structure–activity relationships and mechanisms of action developed from 2017 to the present. The enriched structure–activity relationships may be useful for further rational drug development of triazine hybrids as potential clinical candidates.
Event‐triggered synchronization for stochastic delayed neural networks: Passivity and passification case
Authors: Vadivel R. , Hammachukiattikul P. , Zhu Quanxin , Gunasekaran Nallappan 
Published: November 2022

AbstractThis article investigates the event‐triggered synchronization problem of stochastic neural networks under passivity and passification cases. For saving communication resources, an event‐triggered approach is engaged in the design of synchronization for the delayed stochastic neural networks. To decrease network trouble, an event‐triggered scheme is suggested between the sampler and communication network. A nonfragile event‐triggered controller is intended to guarantee the finite‐time stability of the subsequent closed‐loop system. By applying the Lyapunov–Krasovkii functional (LKF) and the novel integral inequalities, a stability criteria for an interval‐time varying delay error system ensure the designed controller can fulfill the necessities of passivity and passification performance. The desired control gain and event‐triggered parameters are then found based on the linear matrix inequalities (LMIs). Finally, illustrative examples are given to show the benefits and validity of the desired control law.
Prenatal epigenetic factors are predisposing for neurodevelopmental disorders—Considering placenta as a model
Authors: Durbagula Srividhya , Korlimarla Aruna , Ravikumar Gayatri , Valiya Parambath Snijesh , Kaku Sowmyashree Mayur , Visweswariah Ashok Mysore 
Published: November 2022

AbstractThe heterogeneous characteristics of neurodevelopmental disorders (NDDs) have resulted in varied perspectives on their causation. The biology behind the phenotypic heterogeneity in NDDs is not yet well‐defined, but a strong genetic basis has become well accepted as causal for NDDs. Alongside this, there is growing focus on epigenetic mechanisms. The evidence mounting for in‐utero origins of NDDs has promoted research focused on epigenetic mechanisms that impact genes that program early brain development. Considering that placenta is a vital organ, this review emphasizes the prenatal factors and their effects on epigenetic changes influencing the normal functioning of the placenta, and factors mediating pathology in the developing fetus. Overall, it is an attempt to bring focus on the hypothesis that “Prenatal epigenetic factors in the placenta could be predisposing to NDDs (with special interest on autism spectrum disorders).” This review finds growing evidence for epigenetic modifications in the placenta that affect glucocorticoid, nutrient, and immune signaling pathways, eventually impacting fetal brain development. This evidence largely comes from animal models. Given the multicellular nature of placenta, we conclude that, there is a need for placental research focused on employing single‐cell approaches and genome‐wide methylation profiles to bring insights into specific molecular pathways in the placenta that regulate early brain development.
Older patients with COVID‐19 and neuropsychiatric conditions: A study of risk factors for mortality
Authors: Nguyen‐Michel Vi‐Huong , Houot Marion , Delorme Cécile , Sangaré Aude , Gales Ana , Frazzini Valerio , Hanin Aurélie , Aissani Djamal , Trân Thanh , Oquendo Bruno , Ketz Flora , Lafuente‐Lafuente Carmelo , Oasi Christel , Kinugawa Kiyoka , Ouvrard Gaëlle , Ursu Renata , Degos Bertrand , Rohaut Benjamin , Demeret Sophie , Lambrecq Virginie , Navarro Vincent , Fournier Emmanuel , Corvol Jean‐Christophe , Borden Alaina 
Published: November 2022

AbstractBackgroundLittle is known about risk factors for mortality in older patients with COVID‐19 and neuropsychiatric conditions.MethodsWe conducted a multicentric retrospective observational study at Assistance Publique‐Hôpitaux de Paris. We selected inpatients aged 70 years or older, with COVID‐19 and preexisting neuropsychiatric comorbidities and/or new neuropsychiatric manifestations. We examined demographics, comorbidities, functional status, and presentation including neuropsychiatric symptoms and disorders, as well as paraclinical data. Cox survival analysis was conducted to determine risk factors for mortality at 40 days after the first symptoms of COVID‐19.ResultsOut of 191 patients included (median age 80 [interquartile range 74–87]), 135 (71%) had neuropsychiatric comorbidities including cognitive impairment (39%), cerebrovascular disease (22%), Parkinsonism (6%), and brain tumors (6%). A total of 152 (79%) patients presented new‐onset neuropsychiatric manifestations including sensory symptoms (6%), motor deficit (11%), behavioral (18%) and cognitive (23%) disturbances, gait impairment (11%), and impaired consciousness (18%). The mortality rate at 40 days was 19.4%. A history of brain tumor or Parkinsonism or the occurrence of impaired consciousness were neurological factors associated with a higher risk of mortality. A lower Activities of Daily Living score (hazard ratio [HR] 0.69, 95% confidence interval [CI] 0.58–0.82), a neutrophil‐to‐lymphocyte ratio ≥ 9.9 (HR 5.69, 95% CI 2.69–12.0), and thrombocytopenia (HR 5.70, 95% CI 2.75–11.8) independently increased the risk of mortality (all p < .001).ConclusionUnderstanding mortality risk factors in older inpatients with COVID‐19 and neuropsychiatric conditions may be helpful to neurologists and geriatricians who manage these patients in clinical practice.
Unique shape variations of hind and midfoot bones in flatfoot subjects—A statistical shape modeling approach
Authors: Fallon Verbruggen Ferdia , Killen Bryce A , Burssens Arne , Boey Hannelore , Vander Sloten Jos , Jonkers Ilse 
Published: November 2022

AbstractFlatfoot deformity is a prevalent hind‐ and midfoot disorder. Given its complexity, single‐plane radiological measurements omit case‐specific joint interaction and bone shape variations. Three‐dimensional medical imaging assessment using statistical shape models provides a complete approach in characterizing bone shape variations unique to flatfoot condition. This study used statistical shape models to define specific bone shape variations of the subtalar, talonavicular, and calcaneocuboid joints that characterize flatfoot deformity, that differentiate them from healthy controls. Bones of the aforementioned joints were segmented from computed tomography scans of 40 feet. The three‐dimensional hindfoot alignment angle categorized the population into 18 flatfoot subjects (≥7° valgus) and 22 controls. Statistical shape models for each joint were defined using the entire study cohort. For each joint, an average weighted shape parameter was calculated for each mode of variation, and then compared between flatfoot and controls. Significance was set at p < 0.05, with values between 0.05 ≤ p < 0.1 considered trending towards significance. The flatfoot population showed a more adducted talar head, inferiorly inclined talar neck, and posteriorly orientated medial subtalar articulation compare to controls, coupled with more navicular eversion, shallower navicular cup, and more prominent navicular tuberosity. The calcaneocuboid joint presented trends of a more adducted calcaneus, more abducted cuboid, narrower calcaneal roof, and less prominent cuboid beak compared to controls. Statistical shape model analysis identified unique shape variations which may enhance understanding and computer‐aided models of the intricacies of flatfoot, leading to better diagnosis and, ultimately, surgical treatment.
Regulation of DNA‐PK activity promotes the progression of TNBC via enhancing the immunosuppressive function of myeloid‐derived suppressor cells
Authors: Han Jiawen , Wan Minjie , Ma Zhanchuan , Yi Huanfa 
Published: November 2022

AbstractBackgroundDNA‐dependent protein kinase (DNA‐PK) is engaged in DNA damage repair and is significantly expressed in triple negative breast cancer (TNBC). Inhibiting DNA‐PK to reduce DNA damage repair provides a possibility of tumor treatment. NU7441, a DNA‐PK inhibitor, can regulate the function and differentiation of CD4+T cells and effectively enhance immunogenicity of monocyte‐derived dendritic cells. However, the effect of NU7441 on the tumor progression activity of immunosuppressive myeloid‐derived suppressor cells (MDSCs) in TNBC remains unclear.ResultsIn this study, we found that NU7441 alone significantly increased tumor growth in 4 T1 (a mouse TNBC cell line) tumor‐bearing mice. Bioinformatics analysis showed that DNA‐PK and functional markers of MDSCs (iNOS, Arg1, and IDO) tended to coexist in breast cancer patients. The mutations of these genes were significantly correlated with lower survival in breast cancer patients. Moreover, NU7441 significantly decreased the percentage of MDSCs in peripheral blood mononuclear cells (PBMCs), spleen and tumor, but enhanced the immunosuppressive function of splenic MDSCs. Furthermore, NU7441 increased MDSCs' DNA‐PK and pDNA‐PK protein levels in PBMCs and in the spleen and increased DNA‐PK mRNA expression and expression of MDSCs functional markers in splenic MDSCs from tumor‐bearing mice. NU7441 combined with gemcitabine reduced tumor volume, which may be because gemcitabine eliminated the remaining MDSCs with enhanced immunosuppressive ability.ConclusionsThese findings highlight that the regulation of DNA‐PK activity by NU7441 promotes TNBC progression via enhancing the immunosuppressive function of MDSCs. Moreover, NU7441 combined with gemcitabine offers an efficient therapeutic approach for TNBC and merits deeper investigation.
Regorafenib with or without a programmed cell death protein 1 antibody as third‐line treatment for microsatellite stable metastatic colorectal cancer
Authors: He Wen‐Zhuo , Wang Lei , Yin Chen‐Xi , Yi Jia‐Hong , Jin Ya‐Nan , Jiang Chang , Guo Gui‐Fang , Xia Liang‐Ping 
Published: November 2022

AbstractBackgroundAlthough the use of regorafenib plus nivolumab demonstrates promising outcomes in patients with refractory microsatellite stable (MSS) metastatic colorectal cancer (mCRC), this effect has not been substantiated in other studies. Moreover, a comparison between the outcomes of regorafenib and programmed cell death protein 1 (PD‐1) antibody combination therapy and regorafenib monotherapy remains unexplored. In this study, we aimed to assess whether regorafenib and PD‐1 antibody combination therapy is superior to regorafenib monotherapy as a third‐line treatment for MSS mCRC.MethodsPatients with MSS mCRC who received regorafenib and PD‐1 antibody or regorafenib monotherapy as third‐line treatment were eligible for inclusion.ResultsIn total, 179 patients were enrolled, of which 84 were administered regorafenib combined with a PD‐1 antibody and 95 were administered regorafenib monotherapy. Patients administered regorafenib combined with a PD‐1 antibody had similar progression‐free survival (PFS) as those on regorafenib monotherapy (median PFS was 2.4 months and 1.9 months, respectively, p = 0.086). The administration of regorafenib combined with a PD‐1 antibody resulted in significantly longer PFS than that seen with regorafenib monotherapy in both male (5.2 months vs. 2.4 months, p = 0.001) and female (3.9 months vs. 1.8 months, p = 0.037) patients without liver metastasis. Female patients with liver metastasis who were administered regorafenib combined with a PD‐1 antibody had shorter PFS than those administered regorafenib monotherapy (1.8 months vs. 2.0 months, p = 0.030).ConclusionLiver metastasis and sex are predictors of survival benefit following the addition of a PD‐1 antibody to regorafenib in patients with MSS mCRC.