bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beta blockers in HF, reduced EF And Increased HR
Authors: S A Arya Babu , John Ajo 
Published: December 2022

Care for cardiac patient has been revolutionized throughout the past decades. Despite its initiated safety concerns, beta blockers are now one of the most used and safer drugs for the ailment of heart failure. These have proved not only effective for heart failure but also for many other conditions such as migraine headaches, breast cancer to reduce the mortality etc.
Keywords: beta blockers, heart failure with reduced ejection fraction, heart rate
Insulin initiation in Type 2 diabetes mellitus outpatients – data from the multicentre evaluation of type 2 diabetes mellitus outpatients on insulin therapy in Nigeria (METOIN study)
Authors: Nkpozi Marcellinus O , Bozimo GE , Ubani BC , Owolabi FA , Akhidue K , Ezeude CM , Ogbonna SU 
Published: December 2022

People living with type 2 diabetes mellitus (T2DM) have relative insulin deficiency and, therefore, have options to insulin therapy. To be on insulin alone or in combination with other therapies in type 2 DM outpatients is a choice made personalized for each patient. Published literature on the insulin initiation patterns among T2DM outpatients in Nigeria is scanty. The objective of this study, therefore, is to bridge this gap in knowledge. This was a prospective cross sectional study conducted in five tertiary health facilities in Nigeria in which consenting type 2 DM outpatients on insulin therapy alone or in combination with other therapies and who meet the inclusion criteria for the study were recruited. Relevant data relating to insulin use initiation by the patients were analyzed using Statistical Package for Social Sciences (SPSS) version 23.0 software. A total of 268 outpatients living with type 2 DM on insulin therapy, made up of 116 (43.3%) male and 152 (56.7%) females participated in the study. Only 55 (20.5%) of the patients started insulin at onset of diagnosis of T2DM while 46 (17.2%) of the patients started insulin therapy after 5 years of living with T2DM. The duration of living with DM before insulin initiation and the patient's highest level of education were not statistically significant. Insulin initiation was delayed several months to years after diagnosis of T2DM by predominantly endocrinologists in tertiary health facilities but it was initiated in 19 (7.1%) of the T2DM outpatients by primary care physicians (GPs) in peripheral hospitals. It is recommended that diabetes education be intensified for T2DM patients to appreciate the key role of insulin therapy in diabetes care.
Keywords: insulin initiation, type 2 diabetes mellitus outpatients, Nigeria.
Modes ietekme 18. gadsimta otrās puses un 19. gadsimta sākuma Vidzemes sieviešu tradicionālajā apģērbā: krāsu aspekts
Authors: Karlsone Anete 
Published: December 2022

Raksts sniedz ieskatu 18. gadsimta Vidzemes sieviešu tradicionālā apģērba vēstures pētniecībā, pievēršot uzmanību augšslāņu modē aktuālo krāsu izmantojumam arī zemnieku apģērbā. Analizējot 18. gadsimta beigu zemnieku apģērba zīmējumus, kā arī 18.–20. gadsimta rakstītos avotus, mēģināts skaidrot melnu, vienkrāsainu sieviešu svārku jeb brunču un dzeltenu priekšautu valkāšanas tradīciju Vidzemē, tās izplatības hronoloģisko un teritoriālo ietvaru, kā arī šo krāsu iegūšanas tehnoloģiju un saikni ar modes ietekmēm. Veiktie pētījumi apliecina, ka laikā no 18. gadsimta 60. gadiem līdz 19. gadsimta 20. gadu beigām plašā Vidzemes apvidū pie goda tērpa likti dzelteni priekšauti. Tie valkāti kopā ar melniem, vienkrāsainiem brunčiem, kuru teritoriālā un hronoloģiskā izplatība bijusi plašāka nekā minētajiem priekšautiem. Pētāmajā laika periodā Vidzemes zemnieku apģērbā augstāko aprindu modes ietekme izpaudās kā noteiktu krāsu izmantojums, kas nenoliedz arī citu laikmetīgās modes iezīmju pastāvēšanu. Dzeltenā un melnā krāsa saistāma ar atšķirīgiem modes stilu strāvojumiem, no kuriem zemnieciskajā vidē tika pārņemtas atsevišķas to vizuālās izpausmes. Krāsošanas eksperimenti pierādīja augstu ticamības pakāpi rakstītajos avotos minētajām ziņām par konkrētiem 18. gadsimtā lietotajiem krāsaugiem un no tiem iegūstamajiem krāsu toņiem. Vienkrāsainie melnie Vidzemes sieviešu svārki un dzeltenie priekšauti ir uzskatāmi par atbilstošiem minētā laika perioda tradicionālajam zemnieku goda tērpam, lai arī šie priekšmeti līdz mūsdienām nav saglabājušies.
Efficacy and safety of intermittent fasting in people with insulin-treated type 2 diabetes (INTERFAST-2) - a randomized controlled trial
Authors: Obermayer Anna-Maria , J. Tripolt Norbert , Pferschy Peter N. , Kojzar Harald , Aziz Faisal , Müller Alexander , Schauer Markus , Oulhaj Abderrahim , Aberer Felix , Sourij Caren , Habisch Hansjörg , Madl Tobias , Pieber Thomas , Obermayer-Pietsch Barbara , Stadlbauer Vanessa , Sourij Harald 
Published: December 2022

<p> </p>
<p>Objective</p>
<p>To investigate the safety and feasibility of three non-consecutive days of intermittent fasting (IF) per week over 12 weeks in participants with insulin-treated type 2 diabetes. </p>
<p>Research Design and Methods</p>
<p>46 people were randomized to an IF or control group. Dietary counselling and continuous glucose monitoring was provided. Co-primary endpoints were the change in HbA1c from baseline to 12 weeks and a composite endpoint (weight reduction ≥2% and insulin dose reduction ≥10% and HbA1c reduction ≥3mmol/mol).</p>
<p>Results</p>
<p>The IF group showed a significant HbA1c reduction (-7.3±12.0 mmol/mol) compared to the control group (0.1±6.1 mmol/mol) over 12 weeks (p=0.012). The co-primary endpoint was achieved by eight people in the IF and none in the control group (p<0.001). No severe hypoglycemia occurred.</p>
<p>Conclusions</p>
<p>IF is a safe and feasible dietary option to ameliorate glycemic control while reducing total daily insulin dose and body weight in insulin-treated people with type 2 diabetes.</p>
The article is devoted to the study of the peculiarities of legal regulation of relations in the field of provision of rehabilitation services to participants in hostilities in connection with the full-scale invasion of the Russian Federation on the terri
Authors: Kozolys A. 
Published: December 2022

The article is devoted to the study of the peculiarities of legal regulation of relations in the field of provision of rehabilitation services to participants in hostilities in connection with the full-scale invasion of the Russian Federation on the territory of Ukraine. It has been established that relations for the provision of rehabilitation services, focused on determining non-property goods - life and health, arise on the basis of a contract for the provision of rehabilitation services (a contract for medical care of the population), and therefore have a civil law nature. The author's definition of the concept of "civil relations in the field of provision of rehabilitation services to combatants" has been formulated.
The division of civil relations for the provision of rehabilitation services to participants in hostilities was carried out on the basis of both general classification criteria, specific for the differentiation of civil-legal relations, and special criteria taking into account the peculiarities of the studied legal relations, including the specifics of their subject composition.
The author established that the field of health care, in particular the segment of provision of rehabilitation services, is in a permanent state of transformation, and the implementation of medical reform in this field requires significant joint efforts on the part of the domestic legislator, as well as representatives of the legal scientific community. Attention is drawn to the fact that, despite the existence of a number of regulatory and legal documents in Ukraine, which determine the basic principles for creating legal, socio-economic, and organizational conditions in the field of implementation of rehabilitation measures, the normalization of relations related to the provision of rehabilitation services to combatants remains outside the attention of the legislator actions as a result of the military aggression of the Russian Federation against Ukraine. It has been established that the effective implementation of the right to health care by the specified subjects presupposes a primary need for proper legal regulation of civil legal relations in the field of rehabilitation services, and a modern approach to the rehabilitation of combatants should be based on both state support and scientific reasonable concept.
Some issues of legal regulation of the termination of the right to use housing
Authors: Yurkevych Yu. , Maikut Kh. 
Published: December 2022

The article has been devoted to the consideration of problematic aspects of the legal regulation of the termination of the right to use housing. It has been found that the legal regulation of the termination of the right to use housing is carried out by the norms of housing and civil law. Special attention has been drawn to the fact that the Housing Code of Ukraine, despite the legislative changes made to it, does not correspond in content to modern social realities in the conditions of harmonization of the legislation of Ukraine with the law of the European Union. Despite this, it is still used in law enforcement, which often gives rise to numerous collisions and problematic situations.
It has been established that the precedent practice of the Supreme Court, as the highest court in the judicial system of Ukraine, one of the tasks of which, according to the Law of Ukraine "On the Judicial System and the Status of Judges", is to ensure the stability and unity of judicial practice, as well as the uniform application of legal norms by courts of various specializations in the order and manner determined by the procedural law, in the researched sphere of relations is quite diverse.
The necessity of completely updating the housing legislation of Ukraine and bringing it to modern realities has been proved. It has been established that until this issue is unambiguously and clearly settled by the domestic legislator, in eviction cases, everything will depend on the specific factual circumstances, taking into account the person in respect of whom the issue of termination of the right to use residential premises is being decided. Also the attention has been drawn to the fact that the Civil Code of Ukraine is a codified act of legislation adopted later in time, therefore in modern realities the temporal conflict should be resolved precisely in favor of the norms of the Civil Code of Ukraine.
Taking into account the legally guaranteed principle of inviolability of property rights, the property owner has the right to demand the removal of obstacles in exercising the right to use and dispose of his property. Therefore, in the opinion of the authors, it is precisely based on such principles that the issue of terminating the right to use housing that is in private ownership should be regulated.
The principle of humanism as a prerequisite for the content of individual categories of human rights
Authors: Bielova M. , Martselyak M. 
Published: December 2022

It is determined that human and civil rights are the most important institution, which has been developed not only in constitutional law, but also in the theory of law and in other sectoral legislation. In the second half of the XX century, this institution came to the fore, both domestically and internationally. The Institute of Human and Civil Rights and Freedoms is one of the most significant results of the legal development of society, from ancient times to the present day, when human rights have become an essential attribute of a democratic state governed by the rule of law. The modern approach with the declared principles of democracy is somewhat outdated and the whole world needs to rethink the acquired and find new approaches to understanding equality, justice, protection, etc.
The necessary stability of the concept of protection of human and civil rights and freedoms is achieved by relying on a system of principles tested by science and practice. The viability and progressiveness of this concept is formed through a combination of legal, moral, traditional, and other socio-regulatory norms. Taking into account such an approach will prevent legal negativity from becoming a dominant phenomenon of the legal system, restrain the onslaught of legal nihilism and indifference.
It is indicated that the principles are a kind of indicators that demonstrate the degree of development of the law itself, starting points that show the vector of legal regulation. Of course, the principles of law should reflect and express the basic values on which the law is focused, to carry the basis of «ideal» law. The purpose of legal principles is to ensure the ideological unity of lawmaking, law enforcement and law and order in general. They permeate the entire legal system of society, focusing its development on universal, most valuable ideals: democracy, justice, equality, humanism, individual freedom, etc.
Definitely, humanism, as a legal category, is a worldview that considers man as a higher, self-sufficient and self-aware value. Humanism expresses the attitude to man in at least two ways: Thus, humanism is a certain moral requirement for human behavior, ie a certain category of moral awareness of man of the highest social value in the state.
Neutrophil-lymphocyte ratio as a predictor of outcome following traumatic brain injury: Systematic review and meta-analysis
Authors: Mishra Rakesh Kumar , Galwankar Sagar , Gerber Joel , Jain Anuj , Yunus Md. , Cincu Rafael , Moscote-Salazar Luis Rafael , Quiñones-Ossa Gabriel Alexander , Agrawal Amit 
Published: December 2022

Objectives:
The neutrophil-to-lymphocyte ratio (NLR) is a simple and routinely performed hematological parameter; however, studies on NLR as a prognostic tool in traumatic brain injury (TBI) have yielded contradictory results.

Materials and Methods:
This systematic review and meta-analysis was conducted according to the Preferred Reporting Items in the Systematic Review and Meta-Analysis guidelines 2020. Electronic databases of PubMed, Cochrane Library, Web of Science, and Scopus were searched. The population consisted of TBI patients in the absence of moderate and severe extracranial injury. Day 1 NLR was taken for the analysis. The outcomes evaluated were mortality and the Glasgow Outcome Scale (GOS). No restrictions were placed on the language, year and country of publication, and duration of follow-up. Animal studies were excluded from the study. Studies, where inadequate data were reported for the outcomes, were included in the qualitative synthesis but excluded from the quantitative synthesis. Study quality was evaluated using the Newcastle-Ottawa scale (NOS). The risk of bias was estimated using the Cochrane RoBANS risk of bias tool.

Results:
We retrieved 7213 citations using the search strategy and 2097 citations were excluded based on the screening of the title and abstract. Full text was retrieved for 40 articles and subjected to the eligibility criteria, of which 28 were excluded from the study. Twelve studies were eligible for the synthesis of the systematic review while seven studies qualified for the meta-analysis. The median score of the articles was 8/9 as per NOS. The risk of selection bias was low in all the studies while the risk of detection bias was high in all except one study. Ten studies were conducted on adult patients, while two studies reported pediatric TBI. A meta-analysis for GOS showed that high NLR predicted unfavorable outcomes at ≥6 months with a mean difference of −5.18 (95% confidence interval: −10.04, −0.32); P = 0.04; heterogeneity (I2), being 98%. The effect estimates for NLR and mortality were a mean difference of −3.22 (95% confidence interval: −7.12, 0.68), P = 0.11, and an I2 of 85%. Meta-analysis for Area under the curve (AUC) receiver operating characteristic of the included studies showed good predictive power of NLR in predicting outcomes following TBI with AUC 0.706 (95% CI: 0.582–0.829).

Conclusion:
A higher admission NLR predicts an increased mortality risk and unfavorable outcomes following TBI. However, future research will likely address the existing gaps.
POTENSI PENINGKATAN KUALITAS LAYANAN KERETA REL LISTRIK SOLO-JOGJA BERBASIS POLA MOBILITAS KOMUTER
Authors: Chindyana Anita , Romadlon Fauzan , Ananda Ridho 
Published: December 2022

Abstract

One type of transportation that is already available for commuters in Solo and Yogyakarta is the Solo-Jogja Electric Rail Train, which has been operating in February 2021. One of the important things that must be considered by the Electric Rail Train service provider is the quality of service for commuter. This study aims to measure the potential for improving the service of the Solo-Jogja Electric Rail Train, which is measured using 5 variables, namely reliability, comfort, service, vehicle access, and safety. The method used is quanti-tative method and ANOVA statistical test. This study shows that the demographic factor of commuters has a significance with the service variable. The demographic factors are domicile, private vehicle ownership, station distance from home, and the income of travelers. Based on the mobility pattern of the commuters, it can be seen that there is an imbalance in the availability of facilities at large stations and at small stations, which makes travelers prefer to depart from large stations. In addition, the lack of integration between transportation modes at the station is an obstacle for commuters who live in suburban areas. Therefore, additional services are needed to facilitate commuters, especially for those who live in suburban areas.

Keywords: transportation; Electric Rail Train; commuter; station; mobility pattern

Abstrak

Suatu jenis transportasi yang telah tersedia bagi pelaku perjalanan komuter di Solo dan Yogyakarta adalah Kereta Rel Listrik Solo-Jogja, yang mulai beroperasi pada bulan Februari 2021. Salah satu hal penting yang harus diperhatikan oleh penyedia layanan Kereta Rel Listrik tersebut adalah kualitas pelayanan bagi pelaku perjalanan komuter. Penelitian ini bertujuan untuk mengukur potensi peningkatan pelayanan Kereta Rel Listrik Solo-Jogja, yang diukur dengan menggunakan 5 variabel, yaitu reliability, comfort, service, vehicle access, dan safety. Metode yang digunakan adalah metode kuantitatif dan uji statistika ANOVA. Studi ini menunjukkan bahwa faktor demografi pelaku perjalanan komuter memiliki signifikansi dengan variabel pelayanan. Faktor demografi tersebut adalah domisili, kepemilikan kendaraan pribadi, jarak stasiun dari rumah, dan penghasilan pelaku perjalanan. Berdasarkan pola mobilitas pelaku perjalanan komuter, terlihat adanya ketimpangan keter-sediaan fasilitas di stasiun besar dengan di stasiun kecil, yang membuat pelaku perjalanan lebih memilih kebe-rangkatan dari stasiun besar. Selain itu, belum adanya keterpaduan antarmoda transportasi di stasiun menjadi kendala bagi pelaku perjalanan komuter yang berdomisili di daerah pinggiran kota. Karena itu, diperlukan layanan tambahan guna memfasilitasi perjalanan komuter, terutama bagi yang berdomisili di daerah pinggiran kota.

Kata-kata kunci: transportasi; Kereta Rel Listrik; perjalanan komuter; stasiun; pola mobilitas
PENGARUH JENIS PERMUKAAN DAN KONDISI JALAN TERHADAP TINGKAT KECELAKAAN LALU LINTAS DI KOTA BATU
Authors: Kurniawati Risa Amalia , Salsabila Tasyania Izzah , Hawa Putri Nur , Deffinika Ifan 
Published: December 2022

Abstract

The level of traffic accidents that occurs in Indonesia is relatively very high, so the World Health Organization has determined that traffic accidents are the third largest cause of death in Indonesia. Places that are prone to traffic accidents are scattered in areas in Indonesia, one of which is in Batu City. Batu City is a city located in East Java Province, which has a high traffic volume. This is due to the large number of road users who pass through the streets in Batu City, where the roads connect districts and cities. The large number of road users who pass through Batu City has an impact on road damage in Batu City, which has the potential to cause traffic accidents. The factors of the type of road surface and the condition of the damaged road are thought to affect the level of traffic accidents that occur. This study examines the relationship between the type of road surface and the condition of the damaged road with the level of traffic accidents in Batu City. The method used is literature study and the data utilized is secondary data. Data analysis was done using multiple linear regression method. This study shows that the type of road surface and damaged road conditions have a significant effect on the level of traffic accidents that occur in Batu City.

Keywords: traffic accident; traffic; roads; road surface; damaged roads

Abstrak

Tingkat kecelakaan lalu lintas yang terjadi di Indonesia relatif sangat tinggi, sehingga World Health Organization menetapkan bahwa kecelakaan lalu lintas menjadi penyebab kematian terbesar urutan ketiga di Indonesia. Tempat-tempat yang rawan kecelakaan lalu lintas tersebar di daerah-daerah di Indonesia, yang salah satunya adalah di Kota Batu. Kota Batu merupakan sebuah kota yang terletak di Provinsi Jawa Timur, yang mempunyai volume lalu lintas yang tinggi. Hal ini disebabkan karena banyaknya pengguna jalan yang melewati jalan-jalan di Kota Batu, yang mana jalan-jalan tersebut menghubungkan antarkabupaten dan antarkota. Banyaknya pengguna jalan yang melewati Kota Batu berdampak pada rusaknya jalan di Kota Batu, yang berpotensi menyebabkan kecelakaan lalu lintas. Faktor-faktor jenis permukaan jalan dan kondisi jalan yang rusak diduga memengaruhi tingkat kecelakaan lalu lintas yang terjadi. Pada studi ini dikaji hubungan antara jenis permukaan jalan dan kondisi jalan yang rusak dengan tingkat kecelakaan lalu lintas di Kota Batu. Metode yang digunakan adalah studi literatur dan data yang digunakan adalah data sekunder. Analisis data dikerjakan dengan menggunakan metode regresi linier berganda. Studi ini menunjukkan bahwa jenis permu-kaan jalan dan kondisi jalan yang rusak berpengaruh signifikan terhadap tingkat kecelakaan lalu lintas yang terjadi di Kota Batu.

Kata-kata kunci: kecelakaan lalu lintas; lalu lintas; jalan; permukaan jalan; jalan rusak
IMPLEMENTASI PEMBERIAN INFORMASI TENTANG DATA PASIEN PENDERITA COVID-19 TERHADAP PUBLIK DI PUSKESMAS DEMAK III BERDASARKAN UNDANG-UNDANG NOMOR 29 TAHUN 2004 TENTANG PRAKTIK KEDOKTERAN
Authors: Widhiastuti Retno , Mulyani Tri , Sihotang Amri Panahatan 
Published: December 2022

<p>Puskesmas Demak III salah satu bentuk pelayanan Publik dalam bidang pelayanan kesehatan termasuk covid-19.Dalam penelitian ini peneliti berusaha mengangkat permasalahan bagaimana implementasi pemberian informasi tentang data pasien penderita Covid-19 terhadap publik di Puskesmas Demak III berdasarkan Undang-Undang Nomor 29 Tahun 2004 tentang Praktik Kedokteran, kendala dalam implementasi dan upaya mengatasinya. Penelitian ini menggunakan metode yuridis sosiologi, dengan spesifikasi penelitian deskriftif analitik dan metode analisa menggunakan analisa secara kualitatif. Dari hasil penelitian menunjukan bahwa implemantasi pemberian informasi data pasien Covid-19 ke Publik selama masa pandemi dilaksanakan berdasarkan SOP yang dibuat oleh Kepala Puskesmas berpedoman pada Undang-Undang Nomor 29 Tahun 2004 tentang Praktik Kedokteran, Undang-Undang Nomor 14 tahun 2008 Keterbukaan Informasi Publik, Undang-Undang Nomor 36 tahun2009 tentang Kesehatan dan Undang-Undang Nomor 44 tahun 2009 tentang Rumah Sakit.Untuk kendalanya ada 2 hal yaitu: pertama, tumpang tindihnya peraturan perundang-undangan, dalam hal ini dapat diupayakan dengan cara menyusun SOP; kedua, kurangnya SDM, diupayakan dengan cara membuat SK Pelimpahan Tugas dan mengusulkan tenaga dokter umum.</p><p> </p>