bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic, morphological, and biochemical analyses of a multi-metal resistant but multi-drug susceptible strain of Bordetella petrii from hospital soil
Authors: Halder Urmi , Biswas Raju , Kabiraj Ashutosh , Deora Rajendar , Let Moitri , Roy Rajendra Kr , Chitikineni Annapurna , Majhi Krishnendu , Sarkar Shrabana , Dutta Bhramar , Laha Anubhab , Datta Arunava , Khan Dibyendu , Varshney Rajeev K. , Saha Dipnarayan , Chattopadhyay Saswati , Bandopadhyay Rajib 
Published: May 2022

AbstractContamination of soil by antibiotics and heavy metals originating from hospital facilities has emerged as a major cause for the development of resistant microbes. We collected soil samples surrounding a hospital effluent and measured the resistance of bacterial isolates against multiple antibiotics and heavy metals. One strain BMCSI 3 was found to be sensitive to all tested antibiotics. However, it was resistant to many heavy metals and metalloids like cadmium, chromium, copper, mercury, arsenic, and others. This strain was motile and potentially spore-forming. Whole-genome shotgun assembly of BMCSI 3 produced 4.95 Mb genome with 4,638 protein-coding genes. The taxonomic and phylogenetic analysis revealed it, to be a Bordetella petrii strain. Multiple genomic islands carrying mobile genetic elements; coding for heavy metal resistant genes, response regulators or transcription factors, transporters, and multi-drug efflux pumps were identified from the genome. A comparative genomic analysis of BMCSI 3 with annotated genomes of other free-living B. petrii revealed the presence of multiple transposable elements and several genes involved in stress response and metabolism. This study provides insights into how genomic reorganization and plasticity results in evolution of heavy metals resistance by acquiring genes from its natural environment.
Controlling resistive switching behavior in the solution processed SiO2-x device by the insertion of TiO2 nanoparticles
Authors: Kwon Sera , Kim Min-Jung , Lim Dong-Hyeok , Jeong Kwangsik , Chung Kwun-Bum 
Published: May 2022

AbstractThe resistive switching behavior of the solution processed SiOx device was investigated by inserting TiO2 nanoparticles (NPs). Compared to the pristine SiOx device, the TiO2 NPs inserted SiOx (SiOx@TiO2 NPs) device achieves outstanding switching characteristics, namely a higher ratio of SET/RESET, lower operating voltages, improved cycle-to-cycle variability, faster switching speed, and multiple-RESET states. Density functional theory calculation (DFT) and circuit breaker simulation (CB) were used to detail the origin of the outstanding switching characteristic of the SiOx@TiO2 NPs. The improvement in resistive switching is mainly based on the difference in formation/rupture of the conductive path in the SiO2 and SiO2@TiO2 NPs devices. In particular, the reduction of resistance and lower switching voltage of TiO2 NPs control the formation and rupture of the conductive path to achieve more abrupt switching between SET/RESET with higher on/off ratio. This method of combined DFT calculation and CB offers a promising approach for high-performance non-volatile memory applications.
Functionalized electrospun nanofibers for high efficiency removal of particulate matter
Authors: Senthil Rethinam , Sumathi Vijayan , Tamilselvi Alagumuthu , Kavukcu Serdar Batıkan , Aruni A. Wilson 
Published: May 2022

AbstractIn recent years, introducing electrospun airfilters to enhance the removal of PM2.5 and PM10–2.5 has received much interest. In this study, a novel poly-(vinyl) alcohol (PVA)/carbon nanoparticle (CNP)/tea leaf extract (TLE), functionalized nanofibrous air filter (FNA) was fabricated using an electrospinning method. Novelty of the unique work in the blending of CNP and TLE, first of its kind, for the preparation of FNA. Polysaccharide crosslinked FNA has a carbon complex with two monosaccharide units to produce the intrinsic properties of the PM2.5 and PM10–2.5 removal efficiency. The FNA had promising traits of UV protection. The prepared FNA was characterized using physicochemical, mechanical, antimicrobial activity, etc., in addition to its PM2.5 and PM10–2.5 removal efficiency. Pore size and distribution study using the capillary flow porometry method has proved the structure of FNA. FNA exhibited excellent low pressure drop (110 Pa), which are promising characteristics for air purification. FNA from PVA: CNP: TLE exhibited high PM2.5 and PM10–2.5 removal efficiencies of 99.25% and 99.29%, respectively. Hence, the study proved.
Geographic and socioeconomic inequalities in the survival of children under-five in Nigeria
Authors: Okoli Chijioke Ifeanyi , Hajizadeh Mohammad , Rahman Mohammad Mafizur , Khanam Rasheda 
Published: May 2022

AbstractDespite a substantial decline in child mortality globally, the high rate of under-five mortality in Nigeria is still one of the main public health concerns. This study investigates inequalities in geographic and socioeconomic factors influencing survival time of children under-five in Nigeria. This is a retrospective cross-sectional quantitative study design that used the latest Nigeria Demographic Health Survey (2018). Kaplan–Meier survival estimates, Log-rank test statistics, and the Cox proportional hazards were used to assess the geographic and socioeconomic differences in the survival of children under-five in Nigeria. The Kaplan–Meier survival estimates show most under-five mortality occur within 12 months after birth with the poorest families most at risk of under-five mortality while the richest families are the least affected across the geographic zones and household wealth index quintiles. The Cox proportional hazard regression model results indicate that children born to fathers with no formal education (HR: 1.360; 95% CI 1.133–1.631), primary education (HR: 1.279; 95% CI 1.056–1.550) and secondary education (HR: 1.204; 95% CI 1.020–1.421) had higher risk of under-five mortality compared to children born to fathers with tertiary education. Moreover, under-five mortality was higher in children born to mothers’ age ≤ 19 at first birth (HR: 1.144; 95% CI 1.041–1.258). Of the six geopolitical zones, children born to mothers living in the North-West region of Nigeria had 63.4% (HR 1.634; 95% CI 1.238–2.156) higher risk of under-five mortality than children born to mothers in the South West region of Nigeria. There is a need to focus intervention on the critical survival time of 12 months after birth for the under-five mortality reduction. Increased formal education and target interventions in geopolitical zones especially the North West, North East and North Central are vital towards achieving reduction of under-five mortality in Nigeria.
Absence of increased genomic variants in the cyanobacterium Chroococcidiopsis exposed to Mars-like conditions outside the space station
Authors: Napoli Alessandro , Micheletti Diego , Pindo Massimo , Larger Simone , Cestaro Alessandro , de Vera Jean-Pierre , Billi Daniela 
Published: May 2022

AbstractDespite the increasing interest in using microbial-based technologies to support human space exploration, many unknowns remain not only on bioprocesses but also on microbial survivability and genetic stability under non-Earth conditions. Here the desert cyanobacterium Chroococcidiopsis sp. CCMEE 029 was investigated for robustness of the repair capability of DNA lesions accumulated under Mars-like conditions (UV radiation and atmosphere) simulated in low Earth orbit using the EXPOSE-R2 facility installed outside the International Space Station. Genomic alterations were determined in a space-derivate of Chroococcidiopsis sp. CCMEE 029 obtained upon reactivation on Earth of the space-exposed cells. Comparative analysis of whole-genome sequences showed no increased variant numbers in the space-derivate compared to triplicates of the reference strain maintained on the ground. This result advanced cyanobacteria-based technologies to support human space exploration.
Impact of the image alignment over frequency for the VLBI Global Observing System
Authors: Xu Ming H. , Savolainen Tuomas , Anderson James M. , Kareinen Niko , Zubko Nataliya , Lunz Susanne , Schuh Harald 
Published: May 2022

Aims.The VLBI Global Observing System (VGOS), which is the next generation of geodetic very long baseline interferometry (VLBI), observes simultaneously in four frequency bands in the range 3.0-10.7 GHz (expected to be extended to 14 GHz). Because source structure changes with frequency, we aim to study the source position estimates from the observations of this new VLBI system.Methods.Based on an ideal point source model, simulations are run to determine the relation between the source positions as determined by VGOS observations and the locations of the radio emission in the four bands.Results.We obtained the source positions as determined by VGOS observations as a function of the source positions in the four frequency bands for both group and phase delays. The results reveal that if the location of the radio emission in one band is offset with respect to that in the other bands, the VGOS position estimates can be shifted by a larger amount (up to more than three times that offset), possibly in the opposite direction.Conclusions.The VGOS source positions will be highly variable with time and imprecise as to the locations of the radio emission in the four bands if the effects of source structure are not modeled. The image alignment over frequency is essential for modeling these effects, which is the only way to mitigate the impact of such frequency-dependent radio emission on the resulting VGOS source positions.
The Gaia EDR3 view of Johnson-Kron-Cousins standard stars: the curated Landolt and Stetson collections
Authors: Pancino E. , Marrese P. M. , Marinoni S. , Sanna N. , Turchi A. , Tsantaki M. , Rainer M. , Altavilla G. , Monelli M. , Monaco L. 
Published: May 2022

Context. In the era of large surveys and space missions, it is necessary to rely on large samples of well-characterized stars for inter-calibrating and comparing measurements from different surveys and catalogues. Among the most employed photometric systems, the Johnson-Kron-Cousins has been used for decades and for a large amount of important datasets.
Aims. Our goal is to profit from the Gaia EDR3 data, Gaia official cross-match algorithm, and Gaia-derived literature catalogues, to provide a well-characterized and clean sample of secondary standards in the Johnson-Kron-Cousins system, as well as a set of transformations between the main photometric systems and the Johnson-Kron-Cousins one.
Methods. Using Gaia as a reference, as well as data from reddening maps, spectroscopic surveys, and variable stars monitoring surveys, we curated and characterized the widely used Landolt and Stetson collections of more than 200 000 secondary standards, employing classical as well as machine learning techniques. In particular, our atmospheric parameters agree significantly better with spectroscopic ones, compared to other machine learning catalogues. We also cross-matched the curated collections with the major photometric surveys to provide a comprehensive set of reliable measurements in the most widely adopted photometric systems.
Results. We provide a curated catalogue of secondary standards in the Johnson-Kron-Cousins system that are well-measured and as free as possible from variable and multiple sources. We characterize the collection in terms of astrophysical parameters, distance, reddening, and radial velocity. We provide a table with the magnitudes of the secondary standards in the most widely used photometric systems (ugriz, grizy, Gaia, HIPPARCOS, Tycho, 2MASS). We finally provide a set of 167 polynomial transformations, valid for dwarfs and giants, metal-poor and metal-rich stars, to transform UBVRI magnitudes in the above photometric systems and vice-versa.
Therapieentwicklungen bei der Alzheimer-Krankheit
Authors: Grimmer Timo 
Published: May 2022

ZusammenfassungDie Entwicklung neuer Therapien zur Behandlung der Alzheimer-Krankheit ist ein
Fokus der weltweiten Arzneimittelforschung. Es wird an potenteren Therapien zur
symptomatischen Behandlung, insbesondere zur Behandlung von
Verhaltensstörungen, aber auch an Medikamenten, die in die
Pathophysiologie der Erkrankung eingreifen, geforscht, mit dem Ziel, das
Voranschreiten der Alzheimer-Krankheit aufzuhalten oder zumindest zu
verlangsamen. Dazu verlagert sich der Schwerpunkt der Identifikation von
Menschen mit Alzheimer-Krankheit in Stadien der Prä-Demenz wie das der
leichten kognitiven Störung (Mild Cognitive Impairment, MCI oder nahezu
gleichbedeutend beginnende Alzheimer-Demenz: prodromal AD) oder gar in
asymptomatische Stadien. Bisher ermutigendste Ergebnisse liegen für den
Ansatz der passiven Immunisierung mittels monoklonaler Antikörper gegen
Aβ42 vor. Bisher gelang es nicht, mit mehreren abgeschlossenen
zulassungsrelevanten Studien statistisch signifikante Unterschiede auf den
primären Zielparametern zu demonstrieren. Der Antikörper gegen
Amyloid Aducanumab erhielt, basierend auf der Reduktion von Amyloid, eine
vorläufige Zulassung mit Auflagen in den USA; das Zulassungsverfahren
für Europa ist noch im Gange. Die gegenwärtigen
pharmakologischen Ansätze zur Behandlung der Alzheimer-Krankheit bieten
einen begrenzten symptomatischen Nutzen. Bisher ist noch keine
verlaufsverzögernde Behandlung gegen die Alzheimer-Krankheit in
Deutschland auf dem Markt. Daher ist zu empfehlen, Patienten, insbesondere in
prä-dementiellen Stadien oder im Stadium der beginnenden
Alzheimer-Demenz, eine Teilnahme an klinischen Studien zu empfehlen, um die
Entwicklung von neuen und besser wirksamen Medikamenten zur Behandlung der
Alzheimer-Krankheit, die dann vielen Patienten zu Gute kommen können, zu
beschleunigen.
Large-scale and high-depth three dimensional scanning measurement system and algorithm optimization
Authors: Zhang Fan , Li ZhenYang , Zhang Liansheng , Cheng Rongjun , Huang Qiangxian , Li Ruijun , Wang Chaoqun 
Published: May 2022

Tapping scanning mode is an important method for measuring surface topography at the nanometer scale. It is widely used because it can eliminate lateral force and reduce damage to the tested sample. Research on three dimensional (3D) scanning technology with a large range and high depth-to-width ratio has important practical significance and engineering application value because the current scanning probe microscope has the limitations of small measurement ranges and weak Z-direction measurement ability. The high-frequency resonance of the quartz tuning fork, combined with the tungsten stylus, is used in this paper. It has the ability to measure the surface profile of the microdevice with a large aspect ratio. The proposed 3D scanning measurement system has realized a microstructure measurement with a depth of ∼58 µm. The entire measuring range is 400 × 400 × 400 µm3, and the vertical resolution reaches 0.28 nm. The system can accurately obtain the 3D surface topography of the microfluidic biochip. In addition, a sliding window algorithm (SWA) based on errors in the scanning process and low scanning efficiency is proposed. Compared with the point-by-line scanning algorithm, the proposed SWA reduces the mean value of the squared residuals of the 3D profile by 7.70%, thereby verifying the feasibility of the algorithm. The 3D scanning measurement system and the algorithm in the tap mode provide an important reference for the 3D topography measurement of microstructures with large aspect ratios.
Cardiac sympathetic-vagal activity initiates a functional brain–body response to emotional arousal
Authors: Candia-Rivera Diego , Catrambone Vincenzo , Thayer Julian F. , Gentili Claudio , Valenza Gaetano 
Published: May 2022

Significance
We investigate the temporal dynamics of brain and cardiac activities in healthy subjects who underwent an emotional elicitation through videos. We demonstrate that, within the first few seconds, emotional stimuli modulate heartbeat activity, which in turn stimulates an emotion intensity (arousal)–specific cortical response. The emotional processing is then sustained by a bidirectional brain–heart interplay, where the perceived arousal level modulates the amplitude of ascending heart-to-brain neural information flow. These findings may constitute fundamental knowledge linking neurophysiology and psychiatric disorders, including the link between depressive symptoms and cardiovascular disorders.
Modified climbing fiber/Purkinje cell synaptic connectivity in the cerebellum of the neonatal phencyclidine model of schizophrenia
Authors: Veleanu Maxime , Urrieta-Chávez Beetsi , Sigoillot Séverine M. , Paul Maëla A. , Usardi Alessia , Iyer Keerthana , Delagrange Marine , Doyle Joseph P. , Heintz Nathaniel , Bécamel Carine , Selimi Fekrije 
Published: May 2022

SignificanceSynaptogenesis and neural network remodeling are at their maximum during the perinatal period of human brain development. Perturbations of this highly sensitive stage might underlie the etiology of neurodevelopmental disorders. Subchronic neonatal administration of phencyclidine, a drug of abuse, has been used to model schizophrenia in rodents. In this model, we found specific long-term synaptic changes in Purkinje cells and transient gene expression changes in the cerebellum. While transient increased neuronal activity in the cerebellum, induced using chemogenetics, reproduces some phencyclidine-induced molecular changes, it is insufficient to reproduce the long-term synaptic effects. Our results show the complex mechanism of action of phencyclidine on the development of neuronal connectivity and further highlight the potential contribution of cerebellar defects in psychiatric diseases.
Translingual practices and national identity mediated in the semiotized digital spaces
Authors: Sultana Shaila 
Published: May 2022

Abstract
Considering the contradictions in the structured and static approaches to the nation and national identity observed world-wide and fluid trans- approaches to language in applied linguistics and sociolinguistics, the paper explores how national identity is constructed and sustained nowadays, specifically in digital spaces both discursively and non-discursively. Based on the notion of ‘practice’ by Theodore Schatzki (2002), the paper focuses on the translingual practices in relation to national issues and events in Bangladesh drawn from digital spaces through a virtual ethnography. The findings in this paper show that translingual practices and national identity may apparently seem fluid in digital spaces. However, actors nurture beliefs, values, and ideologies in their translingual practices with reference to a territory-based notion of nation, religion, and national identity. Their discursive construction of nation and national identity also seems entangled with a non-discursive bundle of activities and symbolic and material artefacts within material arrangements of spaces. Verbal violence and terrorism accentuating nationalism get immediacy and are concretized in materially mediated semiotized spaces. With an immediate focus on spatial dynamics, while acknowledging the ethos of the post-structuralist approach to language, the paper, hence, indicates the necessity of transgressing the ‘logocentrism’ in language and identity research in applied linguistics and contributing to the recent development in the post-humanist applied linguistics.
Effects of a single impurity in a Luttinger liquid with spin–orbit coupling
Authors: Bahovadinov M S , Matveenko S I 
Published: May 2022

Abstract
In quasi-1D conducting nanowires spin–orbit coupling destructs spin–charge separation, intrinsic to Tomonaga–Luttinger liquid (TLL). We study renormalization of a single scattering impurity in a such liquid. Performing bosonization of low-energy excitations and exploiting perturbative renormalization analysis we extend the phase portrait in K

σ
− K

ρ
space, obtained previously for TLL with decoupled spin–charge channels.
Emergent O(4) symmetry at an one-dimensional deconfined quantum tricritical point
Authors: Xi Ning , Yu Rong 
Published: May 2022

Abstract
We show an O(4) symmetry emerges at a deconfined quantum tricritical point of a valence bond solid (VBS) and two ferromagnetic phases in an S = 1/2 frustrated spin chain by combining analytical analysis and numerical calculations with the time evolution of infinite matrix product states. With this symmetry, the valence-bond solid and the three magnetic order parameters form an O(4) pseudovector in the infrared limit, and can continuously rotate into each other. We numerically determine the location of the quantum tricritical point and study the scaling of the correlation functions of the O(4) vector components and associated conserved currents. The critical behaviors of these correlation functions are all in accord with field theoretical results. The emergent O(4) symmetry at the tricritical point is justified by the integer value of the scaling dimension of the emergent Noether conserved currents. Our findings not only give direct evidence of such a high emergent symmetry at an one-dimensional VBS to magnetic transition but also shed light on exploring emergent symmetries in higher dimensions.
C22 SYNCOPE UNIT AND REMOTE CONTROL IN THE ERA OF COVID–19 PANDEMIC: EXPERIENCE OF A SINGLE CENTER
Authors: Ferrieri A , Dentico A , Epicoco G , Carretta F , D‘Agostino C , Carretta D 
Published: May 2022

Abstract

Introduction
During the pandemic, many Syncope Units were closed due to inclusion of them and staff in Covid departments. In our experience, in order to meet the numerous requests of patients suffering from syncope, the care strategy was chosen to carry out all outpatient procedures within a single access. The use of this protocol made it possible to satisfy user requests, breaking down all barriers, including the fear of Covid–19.

Materials and Methods
The procedural process used in this period at our O.U. was: initial evaluation, execution of Active Stand Test, carotid sinus massage and implantation of loop recorder in a single access. Immediately after implantation, the patient was equipped with remote monitoring. Patients without events were followed only remotely and underwent telephone follow–up approximately every 3 months to update the center on their general state of health and any symptoms. In patients with events, the individual events were examined by the cardiologist and, by telephone follow–up, the presence of symptoms was assessed, correlating the recorded event with the reported symptom. These were subsequently summoned to the clinic.

Results
With this operating model in the years 2020/2021 we managed 53 patients in the Syncope Unit. Of these, 5 underwent PM implantation for loop recorder’s remote monitoring of the paroxysmal AVB, and one patient, for the detection of major ventricular arrhythmias, was protected with Life Vest pending completion of cardiological screening. The remaining patients, thanks to the remote control, are constantly followed at home and monitored with periodic telephone follow–up.

Conclusions
In line with the literature, also in our ER there was a notable reduction in accesses for syncope. Our operating model was virtuous as it served to decongest the ER and the wards, concentrating all patients with syncope in our Syncope Unit and also reducing the number of tests necessary to arrive at an etiological diagnosis of syncope. The Covid–19 pandemic has accelerated the transformation process of the Syncope Unit which is no longer just an elective place for the diagnosis of syncope, but also a fundamental reference for the remote control of ICM wearers.