bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive significance of circulating tumor DNA against patients with T790M- positive EGFR-mutant NSCLC receiving osimertinib
Authors: Yamaguchi Ou , Kasahara Norimitsu , Soda Hiroshi , Imai Hisao , Naruse Ichiro , Yamaguchi Hiroyuki , Itai Miki , Taguchi Kohei , Uchida Megumi , Sunaga Noriaki , Maeno Toshiaki , Minato Koichi , Tomono Hiromi , Ogawara Daiki , Mukae Hiroshi , Miura Yu , Shiono Ayako , Mouri Atsuto , Kagamu Hiroshi , Kaira Kyoichi 
Published: April 2022

Abstract
Background: Circulating tumor DNA (ctDNA) provides molecular information on tumor heterogeneity. Data regarding the predictive significance of ctDNA after first-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are limited. Thus, this study analyzed ctDNA during osimertinib administration as a second-line or greater setting to examine the association between EGFR mutation levels and clinical outcomes in patients with advanced non-small cell lung cancer (NSCLC).Methods: Forty patients with EGFR T790M-positive NSCLC receiving osimertinib after prior EGFR-TKI treatment were enrolled. Plasma samples were obtained at osimertinib pretreatment, after 1 month of treatment, and at the time of progressive disease (PD). ctDNA analysis was performed using digital polymerase chain reaction.Results: The detection rate of copy numbers of exon 19 deletion, L858R, and T790M in plasma samples was significantly lower 1 month after osimertinib treatment than at pretreatment and significantly higher at PD than at 1 month, whereas that of C797S was significantly higher at PD than at 1 month. There was no statistically significant difference in the copy numbers of exon 19 deletion, L858R, T790M, and C797S between complete response or partial response and stable disease or PD.T790M detection at PD after osimertinib initiation was a significant independent prognostic factor for predicting worse prognosis, and the presence of major EGFR mutations at pretreatment and PD was closely associated with shorter survival after osimertinib initiation.Conclusion: Molecular testing based on ctDNA is useful for predicting outcomes of osimertinib treatment in T790M-positive NSCLC after previous EGFR-TKI treatment.
Quantum coherence of a circularly accelerated atom in a spacetime with a reflecting boundary
Authors: Zhang Wanhe , Liu Xiaobao , Yang Tingli , Zhu Kun 
Published: April 2022

Abstract
We investigate, in the paradigm of open quantum systems, the dynamics of quantum coherence of a circularly accelerated atom coupled to a bath of vacuum fluctuating massless scalar field in a spacetime with a reflecting boundary. The master equation that governs the system evolution is derived. It is found that the quantum coherence diminishes to zero with increasing centripetal acceleration and evolution time in the case without a boundary. However, the presence of a boundary will modify the quantum fluctuations of the scalar field, which results in the enhancement of quantum coherence near the boundary compared with that for the unbounded case. Particularly, when the atom is very close to the boundary, although the atom still interacts with the environment, it behaves as if it were a closed system as a consequence of the presence of the boundary, and the quantum coherence can be shielded from the effect of the vacuum fluctuating scalar field.PACS numbers: 03.65.Yz, 03.67.Mn, 03.65.Ta
Relationship between the Glucose to Lymphocyte Ratio and 30-day mortality in acute myocardial infarction patients: An analysis from the MIMIC-IV Database
Authors: Luo Li , Qin Zuoan , Duan Xiangjie , Zhou Quan , Ge Liangqing 
Published: April 2022

Abstract
Aim：To investigate the association between the glucose to lymphocyte ratio (GLR) and 30-day mortality in acute myocardial infarction (AMI) patients. Methods：A retrospective cohort analysis. Two thousand nine hundred and eleven AMI patients were enrolled using the Medical Information Mart for Intensive Care (MIMIC)-IV database. The patients were divided into four groups according to their GLR quantiles. The primary outcome was 30-day mortality. Multivariate Cox proportional risk regression models were used to examine the association between GLR and 30-day mortality. The non-linear relationship between GLR and 30-day mortality was confirmed using a Cox proportional risk regression model fitted by cubic spline function and smooth curve fitting. Results：Of the 2,911 participants, 426 (14.63%) died. The generalized additive model (GAM) showed that the relationship between admission GLR levels and 30-day mortality among AMI patients was non-linear (hazard ratio [HR] 1.01, 95% confidence interval [CI] 1.00–1.02, p = 0.0134). In addition,adjusted multivariable Cox regression analysis confirmed that the admission GLR levels of 3.60-6.06 was independently associated with decreased mortality compared to GLR levels of 0.60–3.59 (HR 1.49, 95% CI 1.02–2.18, p = 0.0409), GLR levels of 6.07–11.03 (HR 1.56, 95% CI 1.07–2.26, p = 0.0203), and GLR levels of 11.04-97.55 (HR 1.69, 95% CI 1.17–2.42, p = 0.0047). A two-piecewise regression model was used to obtain a threshold inflection point value of 4.66. The HR and the 95% CI on the left inflection point were 1.33 and 1.07–1.65, respectively, (p = 0.0116); on the right inflection point, they were 1.01 and 1.01–1.02, respectively, (p = 0.2630). Conclusions：The relationship between the GLR and 30-day mortality was nonlinear in AMI patients. The GLR was positively related with 30-day mortality when the GLR was less than 4.66.
Evaluation of the Experience With the Use of Telemedicine in a Home Dialysis Program - a Qualitative and Quantitative Study
Authors: Monteiro Alexandra , Luciana Motta , Scofano Raquel 
Published: April 2022

Abstract
Introduction: Assisted home hemodialysis is a therapeutic modality for patients diagnosed with End-Stage Renal Disease who require dialysis replacement therapy and have concomitant health limitations that prevent them from attending a satellite dialysis unit or performing their own treatment.Objective: The main objective of this study was evaluated whether telemedicine, through telemonitoring, can improve the ongoing relationship between the doctor, the nurse and the patient.Method: This prospective longitudinal, qualitative and quantitative study analyzes the impact of telemedicine through an evaluation of the experiences of patients and nurses. During the study, we performed remote monitoring weekly 6 months.Results: A total of 17 patients and 12 nurses were included. We observed that the patients and nurses had positive experiences with telemonitoring and highlighted feelings of being care and improved confidence, although they indicated that telemonitoring does not replace face-to-face visits.Conclusion: Telemonitoring is a useful tool to increase satisfaction with and confidence in home hemodialysis.
Acceptance of COVID 19 vaccine among sub-Sahara African (SSA): a comparative study of residents and diaspora dwellers
Authors: Miner Chundung Asabe , Timothy Chikasirimobi G , Mashige Khathutshelo Percy , Osuagwu Uchechukwu Levi , Envuladu Esther Awazzi , Amiebenomo Onyekachukwu Mary-Anne , Charwe Deborah Donald , Goson Piwuna Christopher , Ekpenyong Bernadine N , Abu Emmanuel Kwasi , Langsi Raymond , Oloruntoba Richard , Ishaya Tanko , Ovenseri-Ogbomo Godwin , Agho Kingsley E 
Published: April 2022

Abstract
Background: The COVID-19 vaccines are being rolled out across all the Sub-Saharan Africa (SSA) countries, with countries setting targets for achieving full vaccination rates. The aim of this study was to compare the uptake of, resistance and hesitancy to the COVID-19 vaccine between SSA locally residents and in the diaspora. Methods: This was a cross-sectional study conducted using a web and paper-based questionnaire to obtain relevant information on COVID-19 vaccine acceptance. The survey items included questions on demography, uptake and planned acceptance or non-acceptance of the COVID-19 vaccines among SSAs. Multinomial logistic regression was used to determine probabilities of outcomes for factors associated with COVID-19 vaccination resistance and hesitancy among SSA respondents residing within and outside Africa. Results: Uptake of COVID-19 vaccines varied among the local (14.2%) and diaspora (25.3%) residents. There was more resistance to COVID-19 vaccine among locals (68.1%) and across the sociodemographic variables of sex [adjusted Relative Risk (ARR) =0.73, 95% CI; 0.58 – 0.93], primary/less [ARR =0.22, 95% CI; 0.12 – 0.40] and bachelor’s degree [ARR =0.58, 95% CI; 0.43 – 0.77] educational levels, occupation [ARR =0.32, 95% CI; 0.25 - 0.40] and working status [ARR =1.40, 95%CI; 1.06 - 1.84]. COVID-19 vaccine hesitancy was almost similar between locals and diasporas (17.7% and 17.8% respectively) significant only among healthcare workers [ARR =0.46, 95% CI; 0.16 – 1.35] in the diaspora after adjusting for the variables. Similarly, knowledge and perception of COVID-19 vaccine among locals were substantial, but only perception was remarkable to resistance [ARR =0.86, 95% CI; 0.82 – 0.90] and hesitancy [ARR =0.85, 95% CI; 0.80 – 0.90] of the vaccine. Conclusions: Differences exist in the factors that influence COVID-19 vaccine acceptance between local SSA residents and those in the diaspora. Knowledge about COVID-19 vaccines affects the uptake, resistance, and hesitancy to the COVID-19 vaccine. Information campaigns focusing on the efficacy and safety of vaccines could lead to improved acceptance of COVID-19 vaccines.
Free-Standing Activated Carbon Made from Melamine- Impregnated Paper
Authors: Zhang Yaokun , Lin Xiuyi , Hu Chuanshuang , Yun Hong 
Published: April 2022

Abstract
Aiming at the high value-added utilization of waste scraps of Melamine impregnated paper, also known as “melamine” paper, is a plain base paper or printing decorative paper impregnated with amino resin (melamine formaldehyde resin and urea formaldehyde resin) and dried to a certain extent, with a certain resin content and volatile content of the adhesive paper, after hot pressing can be bonded with each other or with artificial board substrate., this study adopts high temperature pyrolysis method to carbonize the waste impregnated paper to prepare melamine impregnated paper-based activated carbon. The effects of different carbonization temperatures and NaOH/C on the properties of activated carbon materials were studied. When the carbonization temperature is 400℃ and the ratio of alkali to carbon is 2:1, the highest removal rate of methylene blue (MB) by activated carbon is 99.45%, and the specific surface area reaches 608.548 m2/g. Langmuir isotherm, Freundlich isotherm models were used to fit the experimental dye adsorption data, with the Langmuir providing the best fit. This activated carbon adsorbent based on melamine impregnated paper is shown to be highly promising for water decontamination applications.
Augmented Reality indoor tracking using Placenote
Authors: Shewail Ashraf S. , Elsayed Neven A. M. , Zayed Hala H. 
Published: April 2022

Abstract
Recently, augmented reality technology became more stable and integrated into our daytime applications. Augmented reality adds virtual content to enrich physical environments. Augmented reality uses tracking techniques to capture environments features. The tracking is classified into two types: outdoor and indoor tracking. Currently, outdoor tracking becomes popular for outdoor navigation applications using GPS. However, GPS has low performance in indoor tracking due to the imprecision of GPS satellite signals. The deficiencies in the signals make it difficult to navigate through malls, hospitals, museums, and airports. Indoor tracking provides a solution for vast, complex indoor environments navigation. Nowadays, most indoor applications rely on predefined two- and three-dimensional maps of buildings to direct users to their destinations. Our paper presents an indoor tracking model that combines placenote technology with cloud computing technology and A* navigation algorithm. Our model enables users to select a destination without predefined maps, and at the same time, it can calculate the shortest path. Experiments demonstrate that our suggested model achieves an average accuracy about 99 percent within a 7–10 cm error bound in scenarios involving different distance paths. At the same time, the experiments show that all users reach their destinations successfully. The error of the proposed model is significantly lower than the errors reported in the literature for research conducted with markerless technology and tested in similar area sizes.
Effect of hyperbaric oxygen pretreatment on lower body negative pressure endurance of pilots with poor acceleration endurance
Authors: Ma Mengyu , Liu Hongjin , Fu Zhaojun , Liu Qiming , Liu Qiyang , Sun Nannan 
Published: April 2022

Abstract
Background
Aiming at the problem of pilots with poor acceleration endurance, the effects of hyperbaric oxygen pretreatment (HBOP) on improving the lower body negative pressure endurance and centrifuge acceleration endurance of pilots with poor acceleration endurance were investigated.
Methods
Thirty pilots with poor acceleration endurance were subjected to multiple hyperbaric oxygen chambers and 3 oxygen exposures. The lower body negative pressure endurance, centrifuge acceleration endurance, blood pressure (BP), heart rate (HR),blood lactic acid (BLA), hydrogen ion concentration, partial pressure of carbon dioxide (PCO2), partial pressure of oxygen (PO2) and adrenal corticotropic hormone (ACTH) were measured before and after HBOP.
Results
The cumulative stress index increased after HBOP compared with before HBOP (P < 0.05), that is, lower body negative pressure endurance increased. 30 people underwent centrifuge reexamination, and the passing rate of 4.0 G 10 s reached 93.3%. After HBOP, diastolic blood pressure increased, heart rate slowed, lactic acid, hydrogen ion concentration, carbon dioxide partial pressure decreased, oxygen partial pressure increased compared with HBOP, and the changes were significant (P < 0.05)
Conclusion
HBOP can improve the lower body negative pressure endurance and centrifuge acceleration endurance of pilots with poor acceleration endurance.
Generation of corrected hiPSC clones from a Cornelia de Lange Syndrome (CdLS) patient through CRISPR-Cas based technology
Authors: Umbach Alessandro , Maule Giulia , Kheir Eyemen , Cutarelli Alessandro , Foglia Marika , Guarrera Luca , Fava Luca , Conti Luciano , Garattini Enrico , Terao Mineko , Cereseto Anna 
Published: April 2022

Abstract
BackgroundCornelia de Lange syndrome (CdLS) is a rare multisystem genetic disorder which is caused by genetic defects involving the Nipped-B-like protein (NIPBL) gene in the majority of clinical cases (60-70%). Currently, there are no specific cures available for CdLS and clinical management is needed for life. Disease models are highly needed to find a cure. Among therapeutic possibilities are genome editing strategies based on CRISPR-Cas technology. MethodsWe tested CRISPR-Cas technologies including most recent base- and prime editors which introduce modifications without DNA cleavages and compared with sequence substitution approaches through homology directed (HDR) induced by Cas9 nuclease activity. The HDR method that was found more efficient was applied to repair a CdLS-causing mutation in the NIPBL gene. We generated isogenic corrected clones from human induced pluripotent stem cells (hiPSCs) obtained from a CdLS patient carrying the c.5483G>A mutation in the NIPBL gene. ResultsWe discovered that the most efficient method to repair the NIPBL gene is HDR mediated by CRISPR-Cas and induced with a compound (NU7441) inhibiting non-homologous end joining (NHEJ) repair. This sequence repair method allowed us to generate isogenic wild-type hiPSCs clones with regular karyotype and preserved pluripotency. ConclusionsWith this study we generated a CdLS cellular model which will facilitate the investigation of the disease molecular determinants and the identification of therapeutic targets. In particular the hiPSCs cellular models offer the paramount advantage to study the tissue differentiation stages which are altered in the CdLS clinical development. Importantly, the hiPSCs that we have generated are isogenic thus providing the most controlled experimental set up between wild-type and mutated conditions. Finally, the efficient and precise gene replacement strategy developed in this study can be extended to the modification of other genomic loci to produce hiPSCs preserving staminal properties.
Pan-Cancer Prognostic, Immunity, Stemness, and Anticancer Drug Sensitivity Characterization of Pyroptosis Related Genes in Human Cancers
Authors: Wang Zhi-Na , Ma Hong-Ming , Chen Zi-yi , Chen Jia-Wen , Yang Xu-wen , Zhang Nan , Meng Fanjie 
Published: April 2022

Abstract
Pyroptosis related to inflammation has an important role for tumor initiation, progression and metastasis. Our studies described pyroptosis at the pan-cancer level through the tumor immune microenvironment, survival, stemness score, and anticancer drug sensitivity. We evaluate the differential expression of pyroptosis related genes using the Wilcox test of normal human tissues from the Genotype-Tissue Expression project (GTEX), and human cancer tissues from the Cancer Genome Atlas (TCGA). The R packages were used to identify survival analyses of pyroptosis related genes in 33 TCGA cancer types. The correlation between pyroptosis related genes expression and tumor microenvironment, tumor stem cell score, and anticancer drug sensitivity was determined through the Spearman correlation test and Pearson correlation test. The functional enrichment of pyroptosis related genes was investigated using Genes and Genomes (KEGG) and Gene Ontology (GO) analysis. In 18 TCGA cancer types and adjacent normal tissues, the 27 pyroptosis related genes were naturally different. According to correlation analysis, the association between the expression of 27 pyroptosis related genes and the tumor microenvironment revealed that the higher the expression of pyroptosis related genes, the greater the degree of tumor microenvironment. Anticancer drug sensitivity research revealed a favorable connection between anticancer medications and pyroptosis related genes expression such as ELANE, IL18 and CHMP4A (p < 0.05). We studied the association between the immune microenvironment and pyroptosis. The 27 pyroptosis related genes were significantly different in immune subtypes C1 (wound healing), C3 (inflammatory), C2 (IFN-gamma dominant), C5 (immunological quiet), C4 (lymphocyte deficient), and C6 (TGF-beta dominant), as shown in a pan-cancer immune subtype study (p < 0.05). Our research sheds light on the important function that pyroptosis related genes perform in the tumor immune microenvironment, stemness score, and anticancer treatment sensitivity in various cancers. This research was permitted by the Research Ethics Committee of the Emergency General Hospital (No. K202110).
Evaluation complaints of palpitations in patients with Fibromyalgia Syndrome
Authors: GÜNLÜ Serhat , AKTAN Adem 
Published: April 2022

Abstract
Objective
To research the effect of Fibromyalgia Syndrome (FMS) on the cardiac conduction system and evaluate the feasibility of ECG parameters in estimating arrhythmia development with 24-hour ambulatory Holter ECG monitoring.
Method
ECG was taken for all participants of the study. ECG parameters were measured. 24-hour ambulatory Holter ECG monitoring was made and analyzed.
Result
90 patients with FMS and 70 controls were enrolled in the study. The average age of the patient group was 38.3 ± 6.3 years, and the female patient population (73.3%) was almost three times the number of male patients (p = 0.032). In terms of clinical features such as age (p = 0.301), height (p = 0.789), weight (p = 0.628), and body mass index (BMI) (p = 0.770), there was no significant difference between the study and control groups. There was no significant difference between the groups in terms of heart rate (p = 0.800), systolic blood pressure (p = 0.394), and dyslipidemia (p = 0.133). In terms of routine blood tests, there was no significant difference between the study and control groups (p > 0.05). In the comparison of ECG parameters, Pmax, QTd, and QTcd were statistically significant in the study group compared to the control group (p < 0.05). In terms of Pmin and Pdis, there was no significant difference between the two groups (p > 0.05). There was no significant relationship between the study group and the control group in terms of 24-hour Holter ECG recording results (p = 0.182).
Conclusion
Although FM patients complain of palpitations, the outcomes of the study showed that the risk of arrhythmias was not increased.
Nature Inspired Method for Noninvasive Fetal ECG Extraction
Authors: Raj Akshaya , Brablik Jindrich , Kahankova Radana , Jaros Rene , Barnova Katerina , Snasel Vaclav , Mirjalili Seyedali , Martinek Radek 
Published: April 2022

Abstract
This paper introduces a novel algorithm for effective and accurate extraction of non-invasive fetal Electrocardiogram (NI-fECG). In NI-fECG based monitoring, the useful signal is measured along with other signals generated by the pregnant women’s body, especially maternal electro-cardiogram (mECG). These signals are more distinct in magnitude and overlap in time and frequency domains, making the fECG extraction extremely challenging. The proposed extraction method combines the Grey wolf algorithm (GWO) with Sequential Analysis (SA). This innovative combination, forming the GWO-SA method, optimises the parameters required to create a template that matches the mECG, which leads to an accurate elimination of the said signal from the input composite signal. The extraction system was tested on two databases consisting of real signals, namely, Labour and Pregnancy. The results show that the proposed method extracts the fetal ECG signal with an outstanding efficacy. The efficacy of the results was evaluated based on accurate detection of the fQRS complexes. The parameters used to evaluate are as follows: accuracy (ACC), sensitivity (SE), positive predictive value (PPV), and F1 score. Due to the stochastic nature of the GWO algorithm, ten individual runs were performed for each record in the two databases to assure stability as well as repeatability. Using these parameters, for the Labour dataset, we achieved an average ACC of 94.60%, F1 of 96.82%, SE of 97.49%, and PPV of 98.96%. For the Pregnancy database, we achieved an average ACC of 95.66%, F1 of 97.44%, SE of 98.07%, and PPV of 97.44%.
Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea
Authors: Marin-Oto Marta , Sanz-Rubio David , Santamaría-Martos Fernando , Benitez Ivan , Simon Ana L. , Forner Marta , Cubero Pablo , Gil Ana , Sanchez-de-laTorre Manuel , Barbe Ferran , Marin José M. 
Published: April 2022

Abstract
Background. Hypoxia can reduce the levels of soluble receptor for advanced glycation end-products (sRAGE), a new anti-inflammatory biomarker of COPD. We assessed sRAGE in patients with hypoxia-related diseases such as COPD, OSA and OSA-COPD overlap.Methods. Plasma levels of sRAGE were measured in 317 subjects at baseline (57 heathy nonsmokers [HNS], 84 healthy smokers [HS], 79 OSA, 62 COPD and 35 OSA-COPD overlap patients) and in 294 subjects after one year of follow-up (50 HNS, 74 HS, 77 OSA, 60 COPD and 33 overlap).Results. After adjusting for age, sex, smoking status and body mass index, sRAGE levels showed a reduction in OSA (-12.5%, p = 0.005), COPD (-14.8%, p < 0.001) and OSA-COPD overlap (-12,3%, p = 0.02) compared with HNS. There were no differences when comparing sRAGE plasma levels between overlap patients and those with OSA or COPD alone. At follow-up, sRAGE levels did not change significantly in healthy subjects, COPD and OSA or OSA-COPD overlap nontreated with continuous positive airway pressure (CPAP). Moreover, in patients with OSA and OSA-COPD overlap who were treated with CPAP, sRAGE increased significantly.Conclusions. The levels of sRAGE are reduced in COPD and OSA. Treatment with CPAP significantly ameliorated sRAGE levels in patients with OSA who also had COPD.