bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecocriticism, Theology, and the Environment in Haviva Pedaya’s The Eye of the Cat
Authors: Hacohen-Bick Tafat 
Published: February 2022

Abstract
Haviva Pedaya’s book The Eye of the Cat presents an innovative theology of ecology, yet in correspondence with traditional Jewish-Kabbalistic sources. I discuss Pedaya’s ecopoetic reading of these sources, as well as her own midrashim in this regard. Pedaya raises questions regarding the place of man in the world; political questions regarding center and periphery; urbanization and nature; construction and destruction. These questions arise via the book’s unique poetic expression. Pedaya offers a theology of waste, addressing the place of garbage in the human sphere through the Kabbalistic idiom regarding the collection of qlipoth (“husks” ‮קליפות,‬‎). The Kabbalistic project of collecting the qlipoth, which previously functioned in the context of an esoteric and mostly secretive symbolic system, now takes on a different meaning in light of the real “husks” that demand to be collected and reused.
Evaluation of sorghum genotypes for their reaction to major grain molds and mycotoxin-producing fungi in two climates of Ethiopia
Authors: Taye Wondimeneh , Dejene Mashilla , Ayalew Amare , Chala Alemayehu 
Published: February 2022

Abstract
Use of resistant genotype is considered to be the most feasible means to mitigate sorghum grain damage by grain mold in a climate favourable for fungal invasion and subsequent mycotoxin contamination. Field-based experiments were conducted at Babile and Haramaya for two consecutive cropping seasons to evaluate 20 sorghum genotypes for their reaction to grain molds as well as aflatoxin and fumonisin contamination. Aspergillus flavus and Fusarium verticillioides with spore concentrations of 106 ml-1 were inoculated by spraying into the inflorescence, when the anther emerged from approximately 50–70% of the spikelets. Mycotoxin analysis was done using enzyme-linked immunosorbent assay (ELISA). The results revealed that the sorghum genotypes evaluated for their reactions to A. flavus and F. verticillioides inoculation had significantly different responses. Variety Melkam was identified as a susceptible genotype to F. verticillioides and variety Birhan was found resistant to both fungal species. Variety Long Muyera was the most susceptible to both toxigenic fungi. Long Muyera was contaminated with aflatoxin B1 and total fumonisin above the maximum tolerable limit of 10 µg kg-1 and 2000 µg kg-1, respectively. Though the sorghum genotype Birhan was resistant to A. flavus, its aflatoxin B1 contamination was relatively high. In this study, it was recognized that none of the tested sorghum genotypes exhibited possession of multiple resistance to the inoculated toxigenic fungi. Therefore, it is commendable to select and use genotypes, which are resistant to specific toxigenic fungi for a particular location, where the problem exists.
Experiencing and Learning through Story and Educational Drama: A Workshop Example
Authors: Eriksson Stig A. 
Published: February 2022

Abstract
The article introduces the field of educational drama to new readers by outlining foundational concepts and source literature, and some historical roots. Using the well-known folk tale of Hansel and Gretel (Brothers Grimm) as point of departure, the article describes a practical workshop example – with a rationale of the suggested activities.
Detoxification vs non-detoxification before starting an anti-CGRP monoclonal antibody in medication overuse headache
Authors: Pensato Umberto , Baraldi Carlo , Favoni Valentina , Mascarella Davide , Matteo Eleonora , Andrini Giorgia , Cainazzo Maria Michela , Cortelli Pietro , Pierangeli Giulia , Guerzoni Simona , Cevoli Sabina 
Published: February 2022

Background Medication overuse headache significantly contributes to the chronification process and treatment refractoriness of migraine. Currently, abrupt discontinuation of the overused medication still represents the best management strategy for these patients, challenging public health system resources. Methods In this prospective study, chronic migraine and medication overuse headache sufferers with at least 28 days of analgesic consumption per month were included. Assessment of efficacy outcomes at three months were compared among patients who underwent in-hospital abrupt discontinuation of overused acute medication (YES-DETOX group) and patients who did not (NO-DETOX group) before starting an anti-CGRP monoclonal antibody. Results Of 401 patients who received either erenumab or galcanezumab, 28% (n = 111) satisfied inclusion criteria (YES-DETOX n = 28; NO-DETOX n = 83). After three months of treatment, 59% (n = 65; 47/83 YES-DETOX; 18/28 NO-DETOX) patients reverted from medication overuse headache and 51% (n = 57; 42/83 YES-DETOX; 15/28 NO-DEOTX) achieved ≥50% reduction in monthly headache days; yet no statistical differences were observed between the two groups (p = 0.4788 and p = 0.8393, respectively). Monthly consumption of pain medication was the only baseline prognostic factor in multivariate analysis in the overall cohort (p = 0.016). Conclusion Our results support the emerging evidence that anti-CGRP monoclonal antibodies may be effective in medication overuse headache patients irrespective of detoxification, yet further studies are needed to draw definitive conclusions.
Broadening the spectrum of the neurological complications in systemic lupus erythematosus: A patient with meningoradiculitis
Authors: Matthys Arthur , Megdiche Imen , Bardel Benjamin , Remy Philipe , Limal Nicolas , Planté-Bordeneuve Violaine , Gendre Thierry 
Published: February 2022

Background Neurological complications of systemic lupus erythematosus (SLE) are wide and may rarely involve the peripheral nervous system. However, no case of meningoradiculitis has been well-detailed. Methods We report a patient with lupus-associated meningoradiculitis. Results A 57-year-old woman had SLE without neurological involvement, treated with hydroxychloroquine, methotrexate, and prednisone for 10 years. Six months after the drug discontinuation for SLE, she acutely developed gait instability, paresthesia, and neuropathic pain of the four limbs. The neurological examination and nerve conduction studies were consistent with radiculopathies. Cerebrospinal fluid (CSF) analysis showed lymphocytic meningitis. The spinal magnetic resonance imaging (MRI) revealed thickening and an enhancement of the lumbosacral roots consistent with meningoradiculitis. The extensive investigations did not argue for a differential diagnosis of SLE. The patient dramatically improved upon corticosteroids. At the last follow-up, the patient still reported mild paresthesia but the clinical examination, the CSF, and the spinal MRI were normal. Conclusion This well-detailed case of meningoradiculitis broadens the spectrum of neurological complications in SLE. Early recognition of such complications might lead to efficient immunotherapy.
ComPsych communication skills training: Applicability of simulated patients in psychiatry communication skills training
Authors: Ditton-Phare Philippa , Sandhu Harsimrat , Kelly Brian , Loughland Carmel 
Published: February 2022

Objective Communication skills training (CST) programs within postgraduate psychiatry training are rare. ComPsych CST utilises simulated patients (SPs) for trainees to practice communication skills for discussing severe mental illness with patients and their families/carers. This study examined the applicability of using SPs in a psychiatry-specific CST. Methods A total of 41 postgraduate psychiatry trainees attended at least one of four modules of training in their cohort year and completed a questionnaire after each module presenting eight questions rating the use of SPs and ratings of course deliverables. Results Overall, trainees rated contact with SPs very highly across all modules, with a mean rating of 9.11 out of 10 (SD = 0.97). Trainees agreed that SPs appeared authentic, that their reactions showed they listened to the trainee. Conclusions Trainees valued training with SPs, providing evidence that using SPs for psychiatry-specific CST is feasible. Despite subjectivity, this is valuable to course providers as it highlights benefits perceived by trainees to be useful and provides further evidence for the program’s feasibility and utility.
An Opportunity for Improvement: Evaluation of Diabetes Technology Education Among Adult Endocrinology Training Programs
Authors: Fantasia Kathryn L. , Demers Lindsay B. , Steenkamp Devin W. , Modzelewski Katherine L. 
Published: February 2022

Background: Despite increases in continuous glucose monitor (CGM) and insulin pump use in adults with diabetes, there is room for expansion. Technology adoption may be influenced by the training environment and fellowship education. However, little is known about adult endocrinology trainee comfort with, understanding of, or methods by which trainees receive education about diabetes technology. Methods: Mixed methods, sequential explanatory evaluation using survey and semi-structured interviews of endocrinology trainees and fellowship leadership in Accreditation Council for Graduate Medical Education (ACGME)-accredited adult endocrinology fellowship programs to assess trainee and leadership comfort with, perceived knowledge of, and current methods for diabetes technology education. Results: Seventy-seven respondents completed the survey. The majority of training programs have curricula for training on insulin pumps (74%) and CGM (75.3%); 52% of fellows felt curricula are adequate. First- and second-year fellows were more comfortable with CGM than insulin pump use. Only half of third-year fellows felt comfortable with starting insulin pump therapy or recommending insulin dose adjustments based on CGM rate of change arrows. Qualitative interviews identified the importance of both direct instruction and experiential learning in diabetes technology education. Conclusions: Almost half of trainees feel that curricula for learning to use and manage insulin pumps and CGM are inadequate and feel uncomfortable with critical aspects of technology use, demonstrating the need for increased attention to trainee education in the use of diabetes technology. Based on a better understanding of current and preferred methods for instruction, this study provides direction for future development of initiatives to improve fellow education in this field.
Lateral Ulnar Collateral Ligament Reconstruction for Posterolateral Rotatory Instability After Failed Common Extensor Origin Release: Outcomes at Minimum 2-Year Follow-up
Authors: Schneider Marco M. , Müller Konstantin , Hollinger Boris , Nietschke Rainer , Zimmerer Alexander , Ries Christian , Burkhart Klaus J. 
Published: February 2022

Background: In patients with chronic lateral epicondylitis who have failed nonoperative treatment, open or percutaneous release of the common extensor origin (CEO) without subsequent reconstruction tends to result in good clinical outcomes. However, surgery can lead to iatrogenic injuries of the lateral collateral ligamentous complex, causing posterolateral rotatory instability (PLRI). Purpose: To determine the clinical outcomes of lateral ulnar collateral ligament (LUCL) reconstruction using a triceps tendon graft after failed open CEO surgery. Study Design: Case series; Level of evidence, 4. Methods: A total of 103, patients underwent revision surgery at a single institution because of PLRI after failed open release of the CEO (Hohmann procedure) between January 2007 and October 2016. The primary surgery had been performed at other institutions in all cases. Of these patients, 72 were available for follow-up (49 by clinical examination, 23 by telephone interview). Standardized clinical examination; Mayo Elbow Performance Score (MEPS); 11-item version of the Disabilities of the Arm, Shoulder and Hand Score (QuickDASH); subjective elbow value (SEV); and patient satisfaction were assessed at least 2 years after LUCL reconstruction. Results: The mean age of patients in the study was 46.9 years (range, 21-74 years), and the mean follow-up was 2.8 years after revision surgery. The mean MEPS was 78.9, and the mean QuickDASH score reached 20.4. The mean SEV was 78.6%, and 75% of the patients rated the surgery as good to excellent. Complications were detected in 14% of the patients, and 9 needed revision surgery, primarily owing to graft failure with recurrent instability (n = 5). Conclusion: LUCL reconstruction in patients with PLRI after release of the CEO can restore elbow stability and achieve high patient satisfaction. However, outcome scores and revision rates in this cohort were inferior to published outcomes of primary LUCL reconstruction for treatment of noniatrogenic or traumatic PLRI.
A randomized comparison of loss of resistance versus loss of resistance plus electrical stimulation: effect on success of thoracic epidural placement
Authors: Dobson Sean Wayne , Weller Robert Stephen , Edwards Christopher , Turner James David , Jaffe Jonathan Douglas , Reynolds Jon Wellington , Henshaw Daryl Steven 
Published: February 2022

Abstract
Background
Loss of resistance (LOR) for epidural catheter placement has been utilized for almost a century. LOR is a subjective endpoint associated with a high failure rate. Nerve stimulation (NS) has been described as an objective method for confirming placement of an epidural catheter. We hypothesized that the addition of NS to LOR would improve the success of epidural catheter placement.

Methods
One-hundred patients were randomized to thoracic epidural analgesia (TEA) utilizing LOR-alone or loss of resistance plus nerve stimulation (LOR + NS). The primary endpoint was rate of success, defined as loss of sensation following test dose. Secondary endpoints included performance time. An intention-to-treat analysis was planned, but a per-protocol analysis was performed to investigate the success rate when stimulation was achieved.

Results
In the intention-to-treat analysis there was no difference in success rates (90% vs 82% [LOR + NS vs LOR-alone]; P = 0.39). The procedural time increased in the LOR + NS group (33.9 ± 12.8 vs 24.0 ± 8.0 min; P < 0.001). The per-protocol analysis found a statistically higher success rate for the LOR + NS group compared to the LOR-alone group (98% vs. 82%; P = 0.017) when only patients in whom stimulation was achieved were included.

Conclusions
Addition of NS technique did not statistically improve the success rate for epidural placement when analyzed in an intention-to-treat format and was associated with a longer procedural time. In a per-protocol analysis a statistically higher success rate for patients in whom stimulation was obtained highlights the potential benefit of adding NS to LOR.

Trial registration
ClinicalTrials.gov identifier NCT03087604 on 3/22/2017; Institutional Review Board Wake Forest School of Medicine IRB00039522, Food and Drug Administration Investigational Device Exemption: G160273.
Effects of Kinesio taping on forearm supination/pronation performance fatigability
Authors: Hsiao Chih-Kun , Tsai Yi-Jung , Lu Chih-Wei , Hsiung Jen-Chou , Hsiao Hao-Yuan , Chen Yung-Chuan , Tu Yuan-Kun 
Published: February 2022

Abstract
Background
Repetitive exertion in supination/pronation could increase the risk of forearm diseases due to fatigue. Kinesio taping (KT) is a physical therapy technique that decreases muscle tone and musculoskeletal disorders (MSDs) risk. Many assumptions about taping have been made and several studies have considered the taping applications; however, the effect of KT on strength and fatigue of the forearm supination/pronation remains unclear. The purpose of this study was to evaluate the effect of KT on forearm performance fatigability.

Methods
A screwing test was constructed to measure the forearm force loss and screwing efficiency during repetitive supination/pronation. Data from 18 healthy adults who underwent both KT and no taping (NT) sessions were used to investigate the forearm strength change in terms of grip force (GF), driving torque (DT), and push force (PF). The maximal isometric forces before and after the screwing test and force decreasing rate (efficiency) during screwing were evaluated to assess the performance fatigability in KT and NT conditions.

Results
A statistically significant force loss (FL) in maximal isometric GF (p = 0.039) and maximal isometric DT (p = 0.044); however, no significant difference was observed in maximal isometric PF (p = 0.426) between NT and KT. KT provides greater screwing efficiency than NT.

Conclusions
KT could not improve FL in the maximal muscle strength of the forearm in healthy subjects. KT on the forearm was associated with a lesser decline in DT efficiency than NT, implying that KT could decrease the loss rate of muscle strength and delay the development of fatigue; however, the KT did not yield improvements in PF while performing screwing tasks.
Humility in medical practice: a qualitative study of peer-nominated excellent clinicians
Authors: Wadhwa Anupma , Mahant Sanjay 
Published: February 2022

Abstract
Background
Humility has recently been conceptualized as a positive, multifaceted attribute in fields outside of medicine, such as psychology and philosophy. In medicine, there has been limited study into the nature of humility and its role in clinical practice. We sought to develop a deeper understanding of humility in medical practice through the lived-experiences of peer-nominated excellent clinicians.

Methods
We conducted a qualitative study with secondary analysis of transcripts from individual open ended, semi-structured interviews of 13 peer nominated physicians [7 (54%) female] at an academic centre. Using constant comparative analysis, the transcripts were analyzed for instances where humility was discussed as it related to clinical practice.

Results
Participants perceived humility to be an important driver for excellence in clinical practice. This was further explained using two overarching themes: an inward, intellectual perspective and an outward, social perspective. The physician’s inward perspective was their view of their abilities and limits, their self-confidence, and their intellectual openness and adaptability to the limitations and evolving nature of knowledge in medicine. Their outward perspective was an understanding and appreciation for the larger system in which they worked, an openness to others, and valuing patients’ experience. Through these perspectives, humility positively influenced clinical care, learning and curiosity, motivation in the care of others, and relationships with team members and patients.

Conclusions
Humility in medicine is a rich, multifaceted construct that was perceived to be a driver for excellence in medical practice by peer-nominated excellent clinicians. Humility was seen as an active force in formulating and calibrating a clinician’s perspective of self and of others, and as such, positively influencing clinical practice. These findings will help inform a discourse in medical education and faculty development about the important role of humility in medical practice.
Synthesis of aromatic lactone analogues of Lipoxin A4
Authors: Ismael Aya , Zeeshan Muhammad , Hansen Jørn H. 
Published: February 2022

AbstractObjectiveSynthesis of novel aromatic Lipoxin A4 lactone analogues.ResultsNovelpara-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12–13% yields, employing 2-deoxy-d-ribose as a chiral pool starting material and the classicalE-selective Wittig olefination.
CRISPR single base editing, neuronal disease modelling and functional genomics for genetic variant analysis: pipeline validation using Kleefstra syndrome EHMT1 haploinsufficiency
Authors: Fear Vanessa S. , Forbes Catherine A. , Anderson Denise , Rauschert Sebastian , Syn Genevieve , Shaw Nicole , Jamieson Sarra , Ward Michelle , Baynam Gareth , Lassmann Timo 
Published: February 2022

AbstractBackgroundOver 400 million people worldwide are living with a rare disease. Next Generation Sequencing (NGS) identifies potential disease causative genetic variants. However, many are identified as variants of uncertain significance (VUS) and require functional laboratory validation to determine pathogenicity, and this creates major diagnostic delays.MethodsIn this study we test a rapid genetic variant assessment pipeline using CRISPR homology directed repair to introduce single nucleotide variants into inducible pluripotent stem cells (iPSCs), followed by neuronal disease modelling, and functional genomics on amplicon and RNA sequencing, to determine cellular changes to support patient diagnosis and identify disease mechanism.ResultsAs proof-of-principle, we investigated anEHMT1(Euchromatin histone methyltransferase 1; EHMT1 c.3430C > T; p.Gln1144*) genetic variant pathogenic for Kleefstra syndrome and determined changes in gene expression during neuronal progenitor cell differentiation. This pipeline rapidly identified Kleefstra syndrome in genetic variant cells compared to healthy cells, and revealed novel findings potentially implicating the key transcription factors REST and SP1 in disease pathogenesis.ConclusionThe study pipeline is a rapid, robust method for genetic variant assessment that will support rare diseases patient diagnosis. The results also provide valuable information on genome wide perturbations key to disease mechanism that can be targeted for drug treatments.
Patient and provider perspectives on self-administered electronic substance use and mental health screening in HIV primary care
Authors: Lea Alexandra N. , Altschuler Andrea , Leibowitz Amy S. , Levine-Hall Tory , McNeely Jennifer , Silverberg Michael J. , Satre Derek D. 
Published: February 2022

Abstract
Background
Substance use disorders, depression and anxiety disproportionately affect people with HIV (PWH) and lead to increased morbidity and mortality. Routine screening can help address these problems but is underutilized. This study sought to describe patient and provider perspectives on the acceptability and usefulness of systematic electronic, self-administered screening for tobacco, alcohol, other substance use, and mental health symptoms among patients in HIV primary care.

Methods
Screening used validated instruments delivered pre-appointment by both secure messaging and clinic-based tablets, with results integrated into the electronic health record (EHR). Qualitative analysis of semi-structured interviews with 9 HIV primary care providers and 12 patients in the 3 largest HIV primary care clinics in the Kaiser Permanente Northern California health system who participated in a clinical trial evaluating computerized screening and behavioral interventions was conducted. Interviews were audio-recorded and transcribed. A thematic approach was utilized for coding and analysis of interview data using a combination of deductive and inductive methods.

Results
Four key themes were identified: (1) perceived clinical benefit of systematic, electronic screening and EHR integration for providers and patients; (2) usefulness of having multiple methods of questionnaire completion; (3) importance of the patient–provider relationship to facilitate completion and accurate reporting; and (4) barriers, include privacy and confidentiality concerns about reporting sensitive information, particularly about substance use, and potential burden from repeated screenings.

Conclusions
Findings suggest that electronic, self-administered substance use and mental health screening is acceptable to patients and may have clinical utility to providers. While offering different methods of screening completion can capture a wider range of patients, a strong patient–provider relationship is a key factor in overcoming barriers and ensuring accurate patient responses. Further investigation into facilitators, barriers, and utility of electronic screening for PWH and other high-priority patient populations is indicated.
Trial registration ClinicalTrials.gov, NCT03217058. Registered 13 July 2017, https://clinicaltrials.gov/ct2/show/NCT03217058