bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of the Revision Hip Complexity Classification using a modified Delphi technique
Authors: Leong Justin W. Y. , Singhal Rohit , Whitehouse Michael R. , Howell Jonathan R. , Hamer Andrew , Khanduja Vikas , Board Tim N. ,   on behalf of the BHS RHCC expert panel.
Published: May 2022

Aims The aim of this modified Delphi process was to create a structured Revision Hip Complexity Classification (RHCC) which can be used as a tool to help direct multidisciplinary team (MDT) discussions of complex cases in local or regional revision networks. Methods The RHCC was developed with the help of a steering group and an invitation through the British Hip Society (BHS) to members to apply, forming an expert panel of 35. We ran a mixed-method modified Delphi process (three rounds of questionnaires and one virtual meeting). Round 1 consisted of identifying the factors that govern the decision-making and complexities, with weighting given to factors considered most important by experts. Participants were asked to identify classification systems where relevant. Rounds 2 and 3 focused on grouping each factor into H1, H2, or H3, creating a hierarchy of complexity. This was followed by a virtual meeting in an attempt to achieve consensus on the factors which had not achieved consensus in preceding rounds. Results The expert group achieved strong consensus in 32 out of 36 factors following the Delphi process. The RHCC used the existing Paprosky (acetabulum and femur), Unified Classification System, and American Society of Anesthesiologists (ASA) classification systems. Patients with ASA grade III/IV are recognized with a qualifier of an asterisk added to the final classification. The classification has good intraobserver and interobserver reliability with Kappa values of 0.88 to 0.92 and 0.77 to 0.85, respectively. Conclusion The RHCC has been developed through a modified Delphi technique. RHCC will provide a framework to allow discussion of complex cases as part of a local or regional hip revision MDT. We believe that adoption of the RHCC will provide a comprehensive and reproducible method to describe each patient’s case with regard to surgical complexity, in addition to medical comorbidities that may influence their management. Cite this article: Bone Jt Open 2022;3(5):423–431.
Transcatheter Aortic Valve Implantation (TAVI) versus Surgical Aortic Valve Replacement: A Retrospective Analysis from a Tertiary Care Hospital
Authors: Khan Muhammad Ammad , Alam Ghanwa 
Published: May 2022

Since Pakistan is adapting to the technological advancements in the procedure, and shifting to TAVI, more studies are required to evaluate the safe and efficacy of the procedure. The data on the topic is scarce, and our study will aim to fill in the literature gap.
Furthermore, by looking at the burden of cardiac diseases, a policy implementation could be put in place to guide prevention and treatment in the country. We aim to evaluate the efficacy of TAVI procedure and decide whether its a sustainable, cost effective enough of an option when compared to standard open heart surgery in the setting of low and middle income country
C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis Patients
Authors: Amira Elsabagh Abdou , Heba Abd-Elwahab Selim , Amany Mohamed Mohyeldin , Marwa Ahmed Hany 
Published: May 2022

Objective: the albumin to fibrinogen ratio (AFR) and the C-reactive protein (CRP) to albumin ratio (CAR) have been proposed as markers of systemic inflammation. The goal of this study was to differentiate rheumatoid arthritis (RA) patients from healthy people and to study the association between AFR/CAR and DAS28 in RA.Patients and methods. A case control study including 30 RA patients and 30 healthy controls was performed. Fibrinogen, albumin, CRP and erythrocyte sedimentation rate (ESR) were measured. We calculated CAR and AFR in each group and compared them. Correlations of AFR, and CAR with disease activity were examined. Receiver operation characteristic (ROC) curves of AFR and CAR were also used to detect cutoffs for disease activity assessment.Results and discussion. CAR was higher while AFR was lower in RA patients than in control group. ROC curve analyses showed that CAR can be used to detect disease activity of RA at cut off 2.66 with sensitivity 81.3% and specificity 64.3% with an area under the curve (AUC) 0.78. So, CAR was a fair parameter to discriminate disease activity among RA patients. AFR has AUC 0.62, sensitivity 87.5% and specificity 42.9% at cutoff value 5.96. So, in our group AFR was a poor indicator to discriminate disease activity among RA patients.Conclusion. AFR and CAR have been recently proposed as inflammatory markers for assessment of disease activity in RA. AFR and CAR are simple, and inexpensive biomarkers, they also can be rapidly evaluated. CAR was found to be a fair parameter to depict disease activity in RA patients. AFR poorly depicted RA activity.
Results of an open multicenter non-interventional study of clinical efficacy and tolerability of etoricoxib in osteoarthritis and nonspecific back pain with additional evaluation of the effect of the drug on the «central» manifestations of pain
Authors: Karateev A. E. , Polishchuk E. Yu. , Filatova E. S. , Amirdzhanova V. N. , Nesterenko V. A. , Potapova A. S. , Glukhova S. I. , Lila A. M. , Sarapulova A. V. , Mukhin A. A. , Lyusina O. S. , Levasheva L. A. , Kryukova E. V. , Klein D. K. , Kichai N. V. , Kabalyk M. A. , Dobrokhotova N. E. , Grabovetskaya Yu. Yu. , Blagodareva L. A. , Zonova E. V. , Zwinger S. M. , Popov P. P. 
Published: May 2022

The formation of chronic musculoskeletal pain (MSP) is a multifactorial process, in its pathogenesis mechanism of central sensitization (CS) plays an important role.Objective: to evaluate the effectiveness of etoricoxib at a dose of 60 mg per day in diseases accompanied by moderate/severe chronic MPS, with an additional analysis of the effect of this drug on the manifestations of CS.Patients and methods. An open observational study, 790 patients (71.6% women, mean age 54.5±13.0 years) with osteoarthritis and chronic nonspecific back pain received etoricoxib 60 mg/day for 2 weeks. The dynamics of pain, dysfunction, fatigue, sleep disturbances, general health assessment (GHA) on a numerical rating scale (NRS 0–10), as well as signs of CS according to part A of the CSI questionnaire were assessed.Results and discussion. After 2 weeks, the intensity of pain during movement, at rest and at night decreased on average by 58.8±24.1, 69.7±32.6 and 70.1±32.8% respectively; functional insufficiency by 58.2±22.5%, fatigue by 52.2±25.8%, GHA by 50.0±22.6%, sleep improvement by 54.3±25.8% was observed (p<0.001 for all parameters). There was a decrease in the CSI value by an average of 33.1±14.5% (p<0.001), as well as a decrease in the number of patients with highly probable CS (CSI ≥40) from 35.3 to 10.3% (p<0.001). No serious drug-related complications were recorded. The overall frequency of adverse reactions was 5.9%, with dyspepsia and hypertension being the most common.Conclusion. Etoricoxib is an effective and relatively safe treatment for chronic MSP. It reduces the severity of CS, one of the central mechanisms of the pathogenesis of chronic MSP.
Use of telemedicine consultations in rheumatology during the COVID-19 pandemic
Authors: Teplyakova O. V. , Morozova A. A. 
Published: May 2022

Objective: to study the practice of organizing and conducting telemedicine consultations (TMC) of a rheumatological profile, their effectiveness and the main problems that arise during the implementation of this technique.Patients and methods. From June 2020 to December 2021, 102 rheumatological TMCs were performed at the «New Hospital» Medical Association in Yekaterinburg. Patients aged 18–82 years applied for TMC after a face-to-face examination and for the purpose of «pre-consultation». TMC included the following steps: familiarizing the doctor with previous medical reports and the results of examinations; video conference; preparation of final medical report. The Aibolit service and the «Medkarta» platform were used. After TMC, a survey of doctors and patients was conducted to identify the positive and negative aspects of this technique.Results and discussion. Most of the patients who applied for TMC suffered from diseases that required regular monitoring of disease activity (rheumatoid arthritis, psoriatic arthritis, systemic connective tissue diseases), as well as fibromyalgia. Leading reasons for seeking medical advice: exacerbation of the disease or new symptoms onset, the need for laboratory and instrumental monitoring and correction of therapy. The vast majority of patients (90.2%) received answers to all questions and 9.8% – to most of the questions. Doctors had technical problems in 34 (33.3%) cases, including 11 (10.8%) cases when they had to switch to another method of communication.Conclusion. TMK is a promising technique that can be useful and convenient for patients both now, during the COVID-19 pandemic, and in the future. Its main unresolved problems are the recognition of parity between TMK and face-to-face consultations and the improvement of technical conditions.
Organ changes after SARS-CoV-2 infection in a patient with systemic sclerosis according to autopsy
Authors: Vorobeva O. V. , Romanova L. P. 
Published: May 2022

The article presents a description of a clinical case with a fatal outcome due to SARS-CoV-2 coronavirus-induced bilateral viral pneumonia with areas of pneumofibrosis, complicated by acute respiratory failure. The presence of systemic sclerosis in this patient aggravated the course of the disease and became one of the causes of death. Autopsy revealed signs of bilateral pneumonia with lesions in both lungs and areas of pneumofibrosis.Histological examination revealed alveoli with rupture of interalveolar septa, areas of atelectasis, serous-purulent exudate with desquamated alveolocytes, places with organization of exudate, zones of pneumofibrosis. Scleroderma cardiosclerosis, linear necrosis of cardiomyocytes were present in the heart. There were signs of multiple organ failure – pulmonary edema, cerebral edema.
Vaccination in persons with systemic lupus erythematosus: the current state of the problem
Authors: Belov B. S. , Popkova T. V. , Tarasova G. M. , Muravieva N. V. 
Published: May 2022

Vaccination plays an important role in the prevention of infectious diseases in patients with immunoinflammatory diseases. When vaccinating patients with systemic lupus erythematosus (SLE), as with other immunoinflammatory rheumatic diseases, its safety is of great importance, including mitigating the risks of the primary disease or the development of new autoimmune phenomena. Many practitioners continue to consider autoimmune diseases as a contraindication for vaccination due to the perceived possibility of their exacerbation and reduced vaccine effectiveness during active immunosuppressive therapy.The lecture presents current data on the immunogenicity, efficacy and safety of vaccines against a number of infections caused by influenza viruses, hepatitis B, Herpes zoster, human papilloma viruses, COVID-19 and pneumococcus in patients with SLE. It has been shown that the benefits of vaccination in patients with SLE significantly outweigh the risk of adverse events or exacerbations of the disease. At the same time, it was noted that the problem of vaccination of such patients requires further study.
Analysis of the mechanisms of development of neurorheumatological consequences of COVID-19 and the possibility of their pharmacological correction
Authors: Sarvilina I. V. , Lila A. M. , Gromova O. A. , Torshin I. Yu. , Shavlovskaya O. A. , Taskina E. A. 
Published: May 2022

We present the review of clinical and experimental studies on the pathogenesis of neurorheumatological complications (NRC) in COVID-19. The influence of systemic hyperinflammation caused by impaired innate immunity on the functioning of the neurovascular endothelium and the bloodbrain barrier, activation of signaling pathways of innate immunity and parainfectious autoimmunity in the central nervous system were analyzed.Hyperinflammation has been shown to contribute to the development of NRC in COVID-19. The potential therapeutic efficacy of drugs, including those based on chondroitin sulfate, which can be used for the prevention and treatment of NRC in COVID-19, is considered.
Diagnostic value of cone beam computed tomography in complex and compound odontomas: a systematic review and open classification matrix
Authors: Dubron Kathia , Gurniak Anna , Gurniak Eliza , Politis Constantinus , Olszewski Raphael 
Published: May 2022

Objective: Firstly, this review aims to analyse the recent literature about three-dimensional (3D) diagnostic imaging in complex and compound odontomas and compare it to two-dimensional (2D) imaging. Panoramic radiographs help to
evaluate the vertical position of odontomas, and occlusal radiographs are used to evaluate the proximity to adjacent teeth. However, cone beam computed tomography (CBCT) can offer volumetric images, and therefore, a more accurate three-dimensional analysis. Secondly, this research aims to construct an open classification matrix for complex and compound odontomas for dentomaxillofacial CBCT radiology protocols based on a systematic literature review.
Material and methods: Two systematic literature searches were conducted in PubMed (Medline), on 2 February 2022 concerning classification systems, and on 5 February 2022 concerning CBCT images.
Results: In total, these searches revealed 391 papers by reviewing the databases mentioned above. Six articles were selected for inclusion on classification of odontomas and 13 articles were found on CBCT imaging. Consequently, the
construction of an open classification matrix for compound and complex odontomas for dentomaxillofacial CBCT radiology protocols was performed using these 19 articles.
Conclusions: CBCT offers a more precise position and accurate diagnosis of complex and compound odontomas compared to 2D imaging. Consequently, it enhances the detailed view of the site (multiple or unique), location (intraosseous, partially or completely extragnathic), size, extension (bony expansion, thinning or perforation cortical bone), density and type (denticulo type, particle type, denticulo-particle type, denticulo-amorphous type, amorphous tissue), relationship (with the crown or root of the definitive tooth), adjacent teeth resorption (deciduous or definitive), adjacent teeth (retention or impaction), and distance with adjacent structures (inferior alveolar nerve, sinus maxillaris), as well as adequate surgical planning. Moreover, this research presents an open classification matrix for the most complete description of compound and complex odontomas when analysing CBCT imaging.
Pengaruh Buangan Limbah Tambak Terhadap Kelimpahan Perition pada Daun Lamun Enhalus acoroides di Teluk Awur dan Pulau Panjang, Jepara
Authors: Asih Melinda Sri , Widianingsih Widianingsih , Riniatsih Ita 
Published: May 2022

Perifiton merupakan sekelompok organisme yang hidup menempel pada permukaan tumbuhan air yang terendam, tidak menembus substrat, diam atau bergerak di permukaan substrat. Perifiton yang menempel pada daun lamun berperan sebagai faktor penunjang produktivitas primer pada ekosistem lamun, namun apabila kelimpahan perifiton terus meningkat maka akan menghambat pertumbuhan lamun karena lamun akan tertekan dan tidak dapat melakukan fotosintesis dengan baik. Penelitian ini bertujuan untuk mengetahui perbedaan pengaruh buangan limbah tambak terhadap kelimpahan perifiton yang menempel pada daun lamun Enhalus acoroides di Perairan Pantai Teluk Awur dan yang tidak ada buangan limbah tambak di Pulau Panjang, Jepara. Penelitian ini menggunakan Metode Line Transek Kuadran. Pengambilan sampel perifiton dilakukan dengan menggunakan metode sapuan dan pengamatan perifiton dilakukan dengan menggunakan metode sensus dengan bantuan Sedgwick-Rafter. Kelimpahan perifiton di Stasiun 1 dan Stasiun 2 berturut-turut 127,51 ind/cm2 dan 86,25 ind/cm2. Kelimpahan tertinggi ditemukan pada Stasiun 1 karena memiliki pengaruh buangan limbah tambak udang yang ditemukan 3 kelas dan terdiri dari 18 genus, sedangkan pada Stasiun 2 ditemukan 2 kelas yang terdiri dari 13 genus. Kelas perifiton yang mendominasi adalah Bacillariophyceae karena kelas ini dapat bertahan dalam kondisi lingkungan yang tidak stabil. Periphyton is a group of organisms that live attached to the surface of submerged aquatic plants, do not penetrate the substrate, remain stationary or move on the surface of the substrate. Periphyton attached to seagrass leaves acts as a primary productivity supporting factor in the seagrass ecosystem, but if the abundance of periphyton continues to increase it will inhibit seagrass growth because the seagrass will be depressed and unable to perform photosynthesis properly. This study aims to determine the effect of pond waste disposal on the abundance of Enhalus acoroides seagrass periphyton in the waters of Teluk Awur and Panjang Islands, Jepara. This study used the Quadrant Line Transect Method. Periphyton sampling was carried out using the sweeping method and periphyton observations were carried out using the census method with the aid of a Sedgwick-Rafter. The abundance of periphyton at Station 1 and Station 2 is 127.51ind / cm2 and 86.25 ind / cm2, respectively. The highest abundance was found at Station 1 because it influenced shrimp pond waste disposal which was found in 3 classes consisting of 16 genera. The dominating class of periphyton is Bacillariophyceae because this class can survive in unstable environmental conditions.
Optimasi Substrat Dan Pemilihan Co-Substrat Media Kultur Yang Sesuai Terhadap Pertumbuhan Dan Aktivitas Protease Ektraseluler Bakteri Bacillus Firmus Dari Perairan Nusa Lembongan Bali, Indonesia
Authors: Zainuddin Muhammad , Pringgenies Delianis , Radjasa Ocky Karna , Haeruddin Haeruddin , Sabdaningsih Aninditia , Herawati Vivi Endar 
Published: May 2022

Udang merupakan sumber protein hewani yang banyak diminati masyarakat karena citarasa enak dan bergizi. Udang merupakan komoditas perikanan ekspor. Upaya pemenuhan kebutuhan ekspor udang saat ini telah dilakukan budidaya intensif. Budidaya intensif telah terjadi pemberian pakan yang berlebih sehingga terbentuk limbah organik di dasar tambak. Limbah pakan mengakibatkan terbentuknya senyawa nitrit dan amoniak yang toksik bagi udang. Komponen utama limbah ini adalah protein. Protein harus di dekomposisi menjadi asam amino oleh bakteri proteolitik. Salah satu bakteri yang memiliki aktivitas proteolitik adalah bakteri Bacillus Firmus dari simbion sponge Chalinula Pseudomolitba. Tujuan penelitian adalah melakukan optimasi substrat dan pemilihan co-substrat media kultur yang sesuai terhadap pertumbuhan dan aktivitas protease ektraseluler Bacillus Firmus. Penelitian menggunakan metode eksperimen laboratoris. Penelitian terdiri dari uji optimasi substrat, pemilihan Co-substrat C dan N. Hasil penelitian menunjukkan bahwa bakteri Bacillus firmus memiliki laju pertumbuah dan aktivitas protease terbaik pada media kultur dengan subtrat susu skim 1% dengan nilai 0,110 c/jamdan 12,566 c IU/ml. Sumber C terbaik adalah glukosa dengan nilai 0,124 c/jamdan 16,094 cIU/ml. Sumber N terbaik adalah amonium nitrat dengan nilai sebesar 0,137 c/jamdan 19,046 c IU/ml. Shrimp is a source of protein and have good taste. Shrimp is an export commodity. Shrimp cultivation is developing to be intensive. Intensive cultivation uses large amounts of feed. not all of the feed is eaten. leftover feed becomes waste. Feed waste produces nitrite and ammonia. Ammonia is toxic. Feed waste must be cleaned. Decomposition process by proteolytic bacteria. Bacillus Firmus is a proteolytic bacterium from the symbiont sponge Chalinula Pseudomolitba. The research aims to optimize the substrate and select the co-substrate. The study used a laboratory experimental method. The research consisted of a substrate optimization test, selection of Co-substrate C and N. The results showed that Bacillus Firmus had the best growth rate and protease activity on 1% skimmed milk substrate with values of 0.110 c/hour and 12,566 c IU/ml. The best source of C is glucose with a value of 0.124 c/hour and 16,094 c IU/ml. The best source of N as ammonium nitrate with values of 0.137 c/hour and 19,046 c IU/ml.
Penggunaan Citra Satelit Sentinel-2A untuk Mengevaluasi Perubahan Garis Pantai Semarang Jawa Tengah
Authors: Zaidan Rafif Rizki , Suryono Chrisna Adhi , Pratikto Ibnu 
Published: May 2022

Kota Semarang merupakan kota pesisir yang rentan akan pengaruh dari alam dengan kondisi fisik yang berpasir dan berlumpur, topografi yang landai dan adanya banyak kegiatan manusia. Hal tersebut membuat Kota Semarang mengalami perubahan garis pantai yang dinamis dari tahun ke tahun, oleh karena itu perlu dilakukan penelitian secara kontinu untuk memantau perubahan garis pantai yang terjadi. Tujuan dari penelitian ini adalah mengetahui perubahan garis pantai yang terjadi di Kota Semarang menggunakan citra satelit Sentinel-2A. Metode dalam penelitian ini adalah dengan mengaplikasikan penginderaan jauh yang dilanjutkan dengan perhitungan statistik Digital Shoreline Analysis System (DSAS) pada aplikasi penginderaan jauh dan pengolahan data sekunder angin, gelombang dan arus. Hasil penelitian menunjukkan bahwa dalam kurun waktu 2016-2021, garis pantai Kota Semarang mengalami perubahan berupa abrasi seluas 186.34 ha dan akresi sebesar 43.62 ha, dimana abrasi mendominasi perubahan dengan persentase 81%, sementara akresi yang terjadi hanya 19%. Rata-rata jarak dan laju perubahan yang terjadi masing-masing sebesar -32.78 meter dan -6.47 meter/tahun yang menunjukkan perubahan garis pantai berupa abrasi. Secara keseluruhan, pada periode 2016 hingga 2021 Kota Semarang cenderung mengalami pengurangan daratan atau abrasi. The city of Semarang is a coastal city that is vulnerable to the influence of nature with physical conditions of sandy and muddy beach, low topography and the presence of many human activities. This made the city of Semarang experience dynamic coastline changes from year to year, therefore it is necessary to conduct continuous research to monitor changes in coastline that occur. The purpose of this study was to determine changes in the coastline that occurred in the city of Semarang using Sentinel-2A satellite imagery. The method in this study is applying satellite imagery from remote sensing technology followed by statistical calculations using Digital Shoreline Analysis System (DSAS) on remote sensing application and the processing of wind, wave and current as secondary data. The results showed that in the 2016-2021 period, the coastline of Semarang City experienced changes in the form of 186.34 ha of abrasion and 43.62 ha of accretion, where abrasion dominated the change with a percentage of 81%, with accretion of only 19%. The average distance and rate of change that occur are -32.78 meters and -6.47 meters/year, respectively, indicating changes in the coastline in the form of abrasion. Overall, in the period 2016 to 2021, Semarang City tends to experience land reduction or abrasion.