bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of clinoptilolite on heavy metal levels in milk, proinflammatory cytokine responses (IL-1β and IL-6) and oxidative stress in dairy cows
Authors: Kurtdede Efe , Kurtdede Arif , Yasa Duru Sibel , Duru Özkan , Kara Erdal , Aluç Yaşar , Kaya Ufuk 
Published: November 2022

AbstractThe effects of clinoptilolite on milk copper (Cu), lead (Pb), zinc (Zn), cadmium (Cd) and iron (Fe) concentrations, proinflammatory cytokine responses, oxidative stress status, whole blood cell counts and liver and kidney functions were investigated in dairy cows exhibiting no signs of any kind of toxicity. Clinoptilolite was added to the feed at a dose of 200 mg kg−1 body weight in the clinoptilolite-treated group (n = 14), but was not added to the feed in the control group (n = 7). In the milk samples (n = 21) collected before the experiment, the Cu, Pb, Zn, Cd and Fe values were 0.021 ± 0.020, 0.104 ± 0.01, 3.42 ± 0.32, <0.000, 0.56 ± 0.34 ppm, respectively. At the end of the experiment (30th day), among the elements measured in milk samples collected from the clinoptilolite-treated group, only the Pb value (0.076 ± 0.01) was lower than the 0-day value of the clinoptilolite-treated group (0.104 ± 0.01) and the 30th-day value of the control group (0.105 ± 0.01) was found to be statistically lower. Changes determined at the end of clinoptilolite application in serum superoxide dismutase (SOD), malondialdehyde (MDA), albumin, glucose, urea and urine creatinine/urine total protein (uCr/uTP) values, which were interpreted as the effect of lead exposure before the trial, were evaluated as the positive effect of clinoptilolite. It was concluded that the addition of clinoptilolite to the feed in dairy cows caused a significant decrease in the amount of Pb in milk, and positive changes in the parameters related to oxidative stress in serum and in parameters related to renal function.
Na+/K+-ATPase and bone morphogenetic protein-2 expressions in parenchymal and microenvironmental cells of canine mammary tumours
Authors: Ozmen Ozlem 
Published: November 2022

AbstractThe most common canine tumour is mammary tumour, which resembles breast cancer in humans. Microenvironment is a crucial factor in the formation of breast cancers. In order to distinguish between benign and malignant canine mammary tumours, this study looked at the immunohistochemical expression of Na+/K+-ATPase and bone morphogenetic protein-2 (BMP-2) in tumour and microenvironmental cells. The aim of this study was to evaluate the expression of Na+/K+-ATPase and BMP-2 in canine mammary tumours and their relationship with malignancy. In this investigation, 10 normal breast tissues were used as controls, and 28 benign and 46 malignant mammary tumours were taken from the archives of the Department of Pathology. The findings showed that malignant tumours expressed more Na+/K+-ATPase and BMP-2 than did normal breast tissue. Both markers had a negative or slight expression in benign tumours, whereas they considerably increased in malignant tumours. Both tumour parenchymal and microenvironmental cells in malignancies expressed Na+/K+-ATPase and BMP-2. Na+/K+-ATPase expression was observed to be more prominent in cells when compared to BMP-2. These findings also suggest that Na+/K+-ATPase and BMP-2 could be employed in the future to help diagnose canine and possibly human breast cancers earlier or as possible targets for treatment.
New device for taking nine-directional ocular photographs: “9Gaze” application
Authors: Goseki Toshiaki , Kunimi Keiko , Shioya Naoko , Iijima Yuka , Sebe Manami , Hosoya Karin , Fukaya Kyo 
Published: November 2022

This study compared the time required to produce nine-directional ocular photographs using the conventional method to that using the newly devised 9Gaze application. In total, 20 healthy adults, 10 adult patients with strabismus, and 10 pediatric patients with amblyopia or strabismus had their ocular photographs taken using a digital camera with PowerPoint 2010, and with an iPad, and iPod touch with 9Gaze. Photographs of 10 healthy patients were taken by orthoptists with <1 year of experience, and the other participants had theirs taken by those with >1 year of experience. The required time was compared between the three devices in all patients and the two orthoptist groups in 20 healthy adults (>1 year and <1 year of experience). The required times were significantly different between the devices: 515.5 ± 187.0 sec with the digital camera, 117.4 ± 17.8 sec with the iPad, and 76.3 ± 14.1 sec with the iPod touch. The required time with the digital camera was significantly different between the two orthoptist groups (404.7 ± 150.8 vs. 626.3 ± 154.2 sec, P=0.007). The use of the 9Gaze application shortened the recording time required. Furthermore, 9Gaze can be used without considering the years of experience of the examiner.
A meta-analysis on the effect of expertise on eye movements during music reading
Authors: Perra Joris , Latimier Alice , Poulin-Charronnat Bénédicte , Baccino Thierry , Drai-Zerbib Véronique 
Published: November 2022

The current meta-analysis was conducted on 12 studies comparing the eye movements of expert versus non-expert musicians and attempted to determine which eye movement measures are expertise dependent during music reading. The total dataset of 61 comparisons was divided into four subsets, each concerning one eye-movement variable (i.e., fixation duration, number of fixations, saccade amplitude, and gaze duration). We used a variance estimation method to aggregate the effect sizes. The results support the robust finding of reduced fixation duration in expert musicians (Subset 1, g = -0.72). Due to low statistical power because of limited effect sizes, the results on the number of fixations, saccade amplitude, and gaze duration were not reliable. We conducted meta-regression analyses to determine potential moderators of the effect of expertise on eye movements (i.e., definition of experimental groups, type of musical task performed, type of musical material used or tempo control). Moderator analyses did not yield any reliable results. The need for consistency in the experimental methodology is discussed.
*The first two authors equally contributed to the first authorship
Valoración de servicios ambientales por captura de CO2 en un ecosistema de bosque seco tropical en el municipio de El Carmen de Bolívar, Colombia
Authors: Zuluaga Zuluaga Liliana , Castro Escobar Edisson Stiven 
Published: November 2022

Este trabajo de investigación analiza la estructura del ecosistema de bosque seco tropical en siete segmentos estudiados en el municipio de El Carmen de Bolívar, Colombia. Se tiene como objetivo estimar la captura de carbono en el compartimiento fustal, para luego calcular el valor monetario de los servicios ambientales de almacenamiento de CO2. La valoración se realizó utilizando una base de datos construida a partir de un muestreo de árboles por transectos; esto permitió establecer los tipos de especies, densidad, altura comercial y el diámetro a la altura del pecho de la madera. Finalmente se calculó mediante estas variables, el stock de biomasa aérea a través de tres modelos de estimación alométrica. En los resultados se evidencian impactos de origen antropogénico en el bosque, aunque aún hay un número importante de especies nativas; sin embargo estas son principalmente caducifolias, lo que reduce el stock de captura de CO2 debido a los ciclos de defoliación natural. A pesar de esto el ecosistema es un sumidero importante de carbono.
The impact of heavy periods on women with a bleeding disorder
Authors: Sugg Nicola , Morgan Debra 
Published: November 2022

Abstract

Background
Women with a bleeding disorder (WBD), including those diagnosed as a carrier, often have heavy periods associated with prolonged bleeding and pain. This survey sought to describe the impact of this substantial burden on daily living and the personal cost of managing heavy periods.

Methods
An online survey was promoted to women who identify as having a bleeding disorder via the social media of The Haemophilia Society in January and February 2020. The survey included 20 questions about personal data, symptoms and the practicalities of living with a bleeding disorder.

Results
A total of 181 responses were received, of which 151 were complete questionnaires. Of these, 58% of respondents were aged 18–45 and 136 identified as having a bleeding disorder, mostly haemophilia or von Willebrand disease. Thirteen (10%) had been diagnosed as a haemophilia carrier and a further four women were probable carriers. Prolonged or painful periods were reported by the majority of respondents; the median duration of bleeding was 7 days (range 2–42). Thirty-six per cent took time off work or study as a result and 42% reported a negative impact on social life. Eighteen women (13%) reported having to use a combination of sanitary protection products to manage their bleeding. Women diagnosed as a carrier reported morbidity comparable with that of women with a diagnosed bleeding disorder and reported greater use of combinations of sanitary protection.

Conclusion
WBD experience a high prevalence of heavy bleeding and prolonged, painful periods despite using appropriate symptomatic treatment. The impact of heavy periods on women diagnosed as a being a carrier is comparable with that experienced by women with a diagnosed bleeding disorder, but as they are not always clinically recognised they may lack access to care and support.
Youth perspectives on community health in Nunavik: a community-engaged photovoice project
Authors: Pawlowski Madeleine , Riva Mylene , Fletcher Christopher , Lyonnais Marie-Claude , Arsenault-Hudon David 
Published: November 2022

Abstract
Objective
The overall objective of this study was to elicit understandings of community health among Inuit youth aged 12–18 in the region of Nunavik, northern Quebec, through identifying community conditions supporting health from their perspective and exploring how they conceptualize a healthy community.

Methods
In January and February 2020, 51 secondary students from three communities participated in a 1-week participatory photovoice activity during regular class time. Youth participated in three different sessions dedicated to the ethics of taking photographs, taking photos in the community, and group discussions of photographs. Discussions were analyzed via thematic analysis and validated with the youth in the fall of 2020.

Results
Twelve key community conditions supporting health were identified: family, food, culture, language, sense of community belonging, land, housing, services, community, connection, caring and somewhere to go. The youth understood a healthy community to be a place where “nothing was broken” and where community conditions supporting health could be visualized like the rocks in an inuksuk, a stone cairn used by Inuit for wayfinding on the tundra landscape. Participants chose the human form of inuksuk which has become widespread in northern and southern Canadian popular culture.

Conclusion
Findings from this study serve to confirm and strengthen existing models of Inuit health while also raising fresh perspectives and concepts relevant to the younger generation. Images and words of the youth identified in this study may be important in designing effective health promotion strategies that are accessible and relevant to younger generations, thus responding to an important research, programmatic and policy gap.
First experience of total body irradiation in conditioning regimes for allogenic hematopoietic stem cells transplantation in children with acute lymphoblastic leukemia in Saint Petersburg
Authors: Dinikina Yu. V. , Mikhailov A. V. , Rusina M. A. , Smirnova A. Yu. , Vorob’ov N. A. , Kataev N. A. , Kubasov A. V. 
Published: November 2022

Background. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment method of refractory and recurrent forms of acute leukemia in children, while the question of choosing a conditioning regimen in order to achieve the best treatment results remains debatable. Conditioning based on total body irradiation (TbI) was confirmed to be most effective in some trials, but there are still issues of overcoming early and late toxicity, as well as difficulties in planning and routing patients.Aim. To share the experience of interdisciplinary patient management during the conditioning period with TbI inclusion in Saint petersburg, to evaluate the feasibility, toxicity and effectiveness of the method.Materials and methods. patients undergoing allo-HSCT for high risk acute lymphoblastic leukemia conditioned either with TbI (n = 12) or chemotherapy (n = 10) were included. Medical data were retrospectively analyzed with an assessment of the following transplant outcomes: HSCT-associated toxicity, the frequency and severity of infectious complications, graft versus host disease, as well as overall and event-free survival rates. we have evaluated radiotherapy plans in order to assess the compliance of radiation exposure with acceptable values for critical organs.Results. All patients with acute lymphoblastic leukemia in both groups received appropriate myeloablative conditioning. According to the study results, despite the lack of significance, we obtained differences in HSCT-associated mortality (8.3 and 30 %; p = 0.151), 2-years overall and event-free survival (66 ± 13.6 and 36 ± 16.1 %; p = 0.122) in group with TbI and HdCT respectively. It should be noted that there was a trend towards a decrease of toxic reactions frequency in case of TbI-containing regimens; however we didn’t reveal any significant differences in the number of infectious complications during post-transplant period. The median follow-up was 24.2 months and there were no signs of delayed toxicity.Conclusion. TbI-based conditioning was well tolerated with a low incidence of early and delayed toxicity, better overall and event-free survival. based on feasibility of TbI in Saint petersburg hospitals it is possible to recommend the method in routine practice, taking into account clinical indications.
Role of simple ultrasonography rules in preoperative prediction of malignancy of adnexal masses
Authors: Jindal Shaleen Kedarchand , Kulkarni Sayali 
Published: November 2022

Ovarian cancers account to malignancy in pre-menopausal women and post-menopausal women to about 24% and 60% respectively. This makes screening of ovarian cancers and adnexal masses an important part in diagnosis and management of these patients, as they also majorly form a reason for infertility in reproductive age group other than morbidity and mortality in all women. The limited availability of literature on the screening modalities and their definite role in diagnosing malignancy makes it difficult for gynecologists to diagnose the malignancy preoperatively. Ultrasonographic evaluation is considered as one of reliable and accurate diagnostic tool for the diagnosis of the ovarian cancers, so this study on utility of USG rules can help in preoperative screening of malignancy, and prediction of Malignancy helps in planning the management which avoid repeat surgery and morbidity.This study attempts to identify a method for early and accurate diagnosis to provide appropriate treatment for the said diagnosis.An observational comparative study was done and all gynecological patients attending IPD at SAMC and PGI with adnexal masses were evaluated for adnexal masses based on history, clinical examination, USG findings and routine preoperative investigations. Her pre operative diagnosis was co-related with histopathological report. After proper data collection, data was organized and analyzed with the application of Pearson chi-square test and associations were studied among the ultrasound findings and the final histopathological finding using p-value.Among the above said variables assessed by Pearson chi square test they were found to be significantly associated with each other having high p values. So we can predict the risk of malignancy early by using Simple Ultrasonographic Rules as a diagnostic tool and accordingly earlier diagnosis can be made possible by this, thereby preventing both morbidities and mortalities in patient presenting with adnexal masses.
High risk pregnancies and implications of color Doppler
Authors: Vangani Veena , Vangani Mahendra , Vangani Bhavya 
Published: November 2022

The aim of this study is High risk pregnancies & implications of color Doppler. Total 100 were selected with purposive sampling technique, (50 cases) study group of high risk pregnancy taken into the study & compared with an equal number of women with normal pregnancy without complication. In our study we found, maximum cases in age group of 24-34 i.e. 49% in group A whereas in group B 43% in more than 34 age group. 41% normal in group A whereas 27% in group B. C-section 79% in group a & 21% in group B. Emergency caesarean section was uncommon in subjects with normal Doppler USG than those of with abnormal Doppler USG and also from group B.In high risk women like pre eclampsia, diabetes & IUGR. Color Doppler flow velocimetry done repeatedly can predict address foetal events with a great degree of accuracy. Results obtained in study where clinically & statistically significant. Every tertiary hospital should routinely make use of facility for the assessment of fetal wellbeing in high risk cases & ensure a better perinatal outcome.Color Doppler can be used as most effective for fetal surveillance in high risk pregnancy cases. Most importantly it helps in guiding early intervention and outcome.
Fetomaternal outcomes of emergency obstetric hysterectomy in a tertiary care teaching hospital in eastern India: A prospective study
Authors: Ghosh Abantika , Mandal Suchita , Gharami Somasree , Show Pritilata 
Published: November 2022

To evaluate frequency, indications, demographic characters and the fetomaternal outcomes of emergency obstetric hysterectomy in a tertiary care teaching hospital in Eastern India. Prospective, unicentric study. Records of all cases undergoing emergency obstetric hysterectomy in the emergency operation theatre of department of obstetrics and gynecology during the study period were analyzed as per required variables and data was processed to evaluate the results.: A total 22 obstetric hysterectomies were carried out during the study period, 7 (31.81%) cases following vaginal delivery and 15 (68.18%) cases during or following caesaren section. The incidence of obstetric hysterectomy was 0.63 per thousand deliveries. The mean age of the subjects was 26.81 ± 1.11 years. Placenta accreta spectrum was the most frequent indication for obstetric hysterectomy (36.36%). Hypotension requiring the use of vasopressors (77.27%) was the commonest complication faced by the subjects. Mortality rate amongst the subjects was 9.09%. Fetal outcomes were varied. 68.18% of the newborns were healthy. The mortality rate among the newborns was 9.09%.
Bimodal approach for a case of cervical ectopic pregnancy
Authors: Kumari Moturi Veera Durga , Shanthi Nalli , Rajachander Niranjani 
Published: November 2022

Ectopic pregnancy though rare can be a life threatening obstetric emergency without prompt diagnosis and treatment, can lead to significant mortality and morbidity. Incidence of Cervical ectopic pregnancy is &#60;1%. The only viable option was hysterectomy in the past. However, at present various uterine conservative methods are available and can be life saving and drastically decreases the morbidity associated.28yrs G3P1L1A1 at 12 weeks 6 days of gestation with previous LSCS with previous history of Dilation & Evacuation came with USG report showing cervical ectopic pregnancy. Managed initially with 2doses of systemic methotrexate, in view of persistent complaints of spotting pervaginum patient underwent endocervical curettage.Early diagnosis and treatment of cervical ectopic pregnancy with combined approach can effectively reduce the chances of life threatening hemorrhage.
Anamoly scan: A mandatory screening tool
Authors: Maini Manvi , Maan Monika , Kathpalia Sukesh 
Published: November 2022

: Congenital anomalies can be due to various reasons. Some of these can significantly affect the viability of the fetus, some may impair quality of life subsequent to delivery and some may not have any significant effect. It is necessary to determine presence of congenital anomalies in-utero for better maternal and neonatal outcomes.: To determine presence of congenital anomalies in mothers visiting antenatal clinics by conducting a second trimester anomaly scan.: The study evaluated 2000 mothers visiting antenatal care in D. Y Patil Medical College and Hospital in Pune. A second trimester anomaly scan was conducted between 18-20 weeks of gestation in all the patients.: The rate of fetal anomalies noted were 0.8% (16/2000 cases). 13 congenital anomalies were incompatible for viability of the fetus and hence were terminated. 3 congenital anomalies were minor in nature and hence continuation of pregnancy was advised. 2 mothers who were unbooked during antenatal period, delivered anomalous babies and were as well included in the evaluation.: A second trimester anomaly scan should be made mandatory to identify any malformation in the growing fetus as we still have an option to terminate the pregnancy and save the family from the future setback. Also, with the advent of fetal medicine we can identify and treat the fetus in utero which might reduce the future complications.
To determine the role of Anterior segment optical coherence topography (AS-OCT) pre- operatively to detect pre-existing weakness of the posterior capsule in patient of posterior polar cataract (PPC) effecting outcomes during phacoemulsification
Authors: Kumar Santosh , Singh Dhanishankar , Singh Vinod Kumar , Saini Sanchita , Rana Jagriti , Singh Arti 
Published: November 2022

To determine the role of anterior segment optical coherence topography (AS-OCT) pre- operatively to detect pre-existing weakness of the posterior capsule in patient of posterior polar cataract (PPC) effecting outcomes during phacoemulsification.A prospective observational study was done in 26 eyes with clinically diagnosed PPC who underwent phacoemulsification between November 2018 to December 2019. AS-OCT was done preoperatively to detect pre existing dehiscence of posterior capsule in patient of PPC. The images obtained by AS-OCT were divided into either intact or dehiscent. Integrity of posterior capsule was also observed during operation by surgeon.In 26 eyes, dehiscence of posterior capsule was detected in 4 eyes (15.4%) by AS-OCT pre operatively, of posterior capsule in 3 eyes (11.5%) and intact posterior capsule in 23 eyes (88.5%). Rupture of posterior capsule occurred in 4 eyes during phacoemulsification. 3 out of 4 eyes who had rupture, had dehiscence of posterior capsule that was noted by AS-OCT and also intraoperatively while 1 eye was detected to have intact posterior capsule. The sensitivity of AS-OCT was 75% for detecting posterior capsule dehiscence and specificity was 95.65%.: AS-OCT can be used preoperatively to identify posterior polar cataract that are at risk of posterior capsule rupture. This provides preoperative information to surgeon and helps in proper counselling of patients about the prognosis.