bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of female age with outcome of IVF in a low‐resource setting
Authors: Adebayo Francis O. , Ameh Nkeiruka , Adesiyun Adebiyi G. , Ekele Bissallah A. , Wada Ibrahim 
Published: November 2022

AbstractObjectiveTo determine the effect of female age on pregnancy outcome after in vitro fertilization/embryo transfer (IVF‐ET).MethodsA prospective study was conducted involving 266 women who had IVF‐ET at Nisa Fertility and Genetic Center, Abuja, Nigeria. All eligible consenting women were recruited to the study. The main outcome measure was clinical pregnancy. Data were analyzed using IBM SPSS Statistics version 25. P < 0.05 at 95% confidence intervals was taken as significant.ResultsA total of 266 patients were recruited and included in the study; 104 pregnancies were recorded, giving an overall pregnancy rate of 39.1%. The age range of the patient was 26–43 years (mean age 33.9 ± 2.41 years) while the mean number of embryo transfers per patient was 2.2. The clinical pregnancy rate for women aged below 30 years was 69.4% while the pregnancy rate for patients aged 30–34 years, 35–39 years, and 40–43 years was 52.6%, 24.7%, and 9.4%, respectively (P < 0.0001).ConclusionThe study found that the success rate of IVF‐ET decreases significantly in women aged over 34 years. Women should be counseled about the age‐related risk of infertility and referred to a fertility center as early as possible.
Multimodal magnetic resonance imaging for Alzheimer's disease diagnosis using hybrid features extraction and ensemble support vector machines
Authors: Houria Latifa , Belkhamsa Noureddine , Cherfa Assia , Cherfa Yazid 
Published: November 2022

AbstractMagnetic resonance imaging (MRI) is increasingly used in the diagnosis of Alzheimer's disease (AD) in order to identify abnormalities in the brain. Indeed, cortical atrophy, a powerful biomarker for AD, can be detected using structural MRI (sMRI), but it cannot detect impairment in the integrity of the white matter (WM) preceding cortical atrophy. The early detection of these changes is made possible by the novel MRI modality known as diffusion tensor imaging (DTI). In this study, we integrate DTI and sMRI as complementary imaging modalities for the early detection of AD in order to create an effective computer‐assisted diagnosis tool. The fused Bag‐of‐Features (BoF) with Speeded‐Up Robust Features (SURF) and modified AlexNet convolutional neural network (CNN) are utilized to extract local and deep features. This is applied to DTI scalar metrics (fractional anisotropy and diffusivity metric) and segmented gray matter images from T1‐weighted MRI images. Then, the classification of local unimodal and deep multimodal features is first performed using support vector machine (SVM) classifiers. Then, the majority voting technique is adopted to predict the final decision from the ensemble SVMs. The study is directed toward the classification of AD versus mild cognitive impairment (MCI) versus cognitively normal (CN) subjects. Our proposed method achieved an accuracy of 98.42% and demonstrated the robustness of multimodality imaging fusion.
Schwann Cells Contribute to Alveolar Bone Regeneration by Promoting Cell Proliferation
Authors: Zhang Xiaohan , Xiong Qiuchan , Lin Weimin , Wang Qian , Zhang Danting , Xu Ruoshi , Zhou Xinyi , Zhang Shiwen , Peng Lin , Yuan Quan 
Published: November 2022

ABSTRACTThe plasticity of Schwann cells (SCs) following nerve injury is a critical feature in the regeneration of peripheral nerves as well as surrounding tissues. Here, we show a pivotal role of Schwann cell-derived cells in alveolar bone regeneration through the specific ablation of proteolipid protein 1 (Plp)-expressing cells and the transplantation of teased nerve fibers and associated cells. With inducible Plp specific genetic tracing, we observe that Plp+ cells migrate into wounded alveolar defect and dedifferentiate into repair SCs. Notably, these cells barely transdifferentiate into osteogenic cell lineage in both SCs tracing model and transplant model, but secret factors to enhance the proliferation of alveolar skeletal stem cells (aSSCs). As to the mechanism, this effect is associated with the upregulation of extracellular matrix (ECM) receptors and receptor tyrosine kinases (RTKs) signaling and the downstream extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway and the phosphoinositide 3-kinase–protein kinase B (PI3K-Akt) pathway. Collectively, our data demonstrate that SCs dedifferentiate after neighboring alveolar bone injury and contribute to bone regeneration mainly by a paracrine function. © 2022 American Society for Bone and Mineral Research (ASBMR).
Myocardial work—A new tool for early detection of rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone chemotherapy induced‐cardiotoxicity in hematological patients
Authors: Mihalcea Diana , Memis Hayat , Balinisteanu Anca , Vladareanu Ana‐Maria , Mihaila Sorina , Vinereanu Dragos 
Published: November 2022

AbstractBackgroundRituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (RCHOP) chemotherapy in non‐Hodgkin's lymphoma (NHL) has risk of cardiotoxicity.PurposeTo determine the role of myocardial work and biomarkers in subclinical diagnosis and prediction of cardiotoxicity.MethodsThe 130 NHL patients (52 ± 9 years, 62% men) scheduled for RCHOP, with LVEF>50%, were evaluated at baseline, after third cycle and chemotherapy completion for 3D LVEF, 2D myocardial deformation (longitudinal, radial, circumferential strain ‐ LS, RS, CS) and myocardial work (global constructive work, waste work, work index and work efficiency ‐ GCW, GWW, GWI, GWE). NT‐pro‐BNP and troponin I were determined.ResultsAfter chemotherapy ended, 37 patients (28%) (group I) developed asymptomatic cardiotoxicity (8 mild form, 25 moderate form, 4 severe form); 93 patients (group II) did not. After third cycle, all patients had decreased LS, CS, RS, GCW, GWI, GWE and increased GWW, persistent after chemotherapy completion, with significant changes in group I. After third cycle, GWE and GCW were the best independent predictors for LVEF reduction; GWE decrease with>5% after third cycle predicted cardiotoxicity after chemotherapy completed (91% sensitivity, 94% specificity).ConclusionsIn NHL, myocardial work can diagnose subclinical cardiotoxicity and predict LVEF decline. These parameters should be used for sensitive evaluation of myocardial function during chemotherapy.
Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen
Authors: Al Nabhani Ibrahim , Andrews Claire , Sibai Jad , Atenafu Eshetu , Young Taylor , Chan Steven M. , Gupta Vikas , Maze Dawn , Schimmer Aaron D. , Schuh Andre C. , Yee Karen , Sibai Hassan 
Published: November 2022

AbstractPEG‐asparaginase is used as a treatment for Philadelphia‐negative acute lymphoblastic leukemia. In pediatric studies, triglycerides (TGs) were affected more by PEG‐asparaginase than by native L‐asparaginase (10.0% vs. 5.5%). We conducted a retrospective study to determine the safety of re‐challenging adult patients with PEG‐asparaginase after experiencing an episode of severe hypertriglyceridemia (>1000 mg/dl or 11.4 mmol/L). The incidence of hypertriglyceridemia associated with PEG‐asparaginase in adult patients was high (67.5%). Therefore, checking TGs at baseline and monitoring levels while receiving PEG‐asparaginase need to be considered and studied in prospective studies. However, in patients with hypertriglyceridemia not complicated by acute pancreatitis, re‐challenging is safe once TG levels normalize.
Whey‐based polymeric films for food packaging applications: a review of recent trends
Authors: Rosseto Marieli , Rigueto Cesar Vinicius Toniciolli , Alessandretti Ingridy , de Oliveira Rafaela , Raber Wohlmuth Daniela Alexia , Loss Raquel Aparecida , Dettmer Aline , Richards Neila Silvia Pereira dos Santos 
Published: November 2022

AbstractThe food industry is always looking for new strategies to extend the shelf life of food. In recent years, the focus has been on edible films and coatings. These play an essential role in the quality, safety, transport, storage, and display of a wide variety of fresh and processed foods and contribute to environmental sustainability. In this sense, this study aimed to carry out a bibliometric analysis and literature review on the production of whey‐based films for application in food packaging. Whey‐based films have different characteristics when compared to other biopolymers, such as antimicrobial and immunomodulatory capacity. A wide variety of compounds were found that can be incorporated into whey films, aiming to overcome their limitations related to high solubility and low mechanical properties. These compounds range from plasticizing agents, secondary biomacromolecules added to balance the polymer matrix (gelatin, starch, chitosan), and bioactive agents (essential oils, pigments extracted from plants, and other antimicrobial agents). The most cited foods as application matrix were meat (fish, chicken, ham, and beef), in addition to different types of cheese. Edible and biodegradable films have the potential to replace synthetic polymers, combining social, environmental, and economic aspects. The biggest challenge on a large scale is the stability of physical, chemical, and biological properties during application. © 2022 Society of Chemical Industry.
Identification of nine novel variants across PAX3, SOX10, EDNRB, and MITF genes in Waardenburg syndrome with next‐generation sequencing
Authors: Lee Chen‐Yu , Lo Ming‐Yu , Chen You‐Mei , Lin Pei‐Hsuan , Hsu Chuan‐Jen , Chen Pei‐Lung , Wu Chen‐Chi , Hsu Jacob Shujui 
Published: November 2022

AbstractBackgroundWaardenburg syndrome (WS) is a hereditary, genetically heterogeneous disorder characterized by variable presentations of sensorineural hearing impairment and pigmentation anomalies. This study aimed to investigate the clinical features of WS in detail and determine the genetic causes of patients with clinically suspected WS.MethodsA total of 24 patients from 21 Han‐Taiwanese families were enrolled and underwent comprehensive physical and audiological examinations. We applied targeted next‐generation sequencing (NGS) to investigate the potential causative variants in these patients and further validated the candidate variants through Sanger sequencing.ResultsWe identified 19 causative variants of WS in our cohort. Of these variants, nine were novel and discovered in PAX3, SOX10, EDNRB, and MITF genes, including missense, nonsense, deletion, and splice site variants. Several patients presented with skeletal deformities, hypotonia, megacolon, and neurological disorders that were rarely seen in WS.ConclusionThis study revealed highly phenotypic variability in Taiwanese WS patients and demonstrated that targeted NGS allowed us to clarify the genetic diagnosis and extend the genetic variant spectrum of WS.
Experimentally Validated Novel Factor XIIa Inhibitors Identified by Docking and Quantum Chemical Post‐processing
Authors: Ilin Ivan , Podoplelova Nadezhda , Sulimov Alexey , Kutov Danil , Tashchilova Anna , Panteleev Mikhail , Shikhaliev Khidmet , Krysin Mikhail , Stolpovskaya Nadezhda , Potapov Andrey , Sulimov Vladimir 
Published: November 2022

AbstractAntithrombotic agents based on factor XIIa inhibitors can become a new class of drugs to manage conditions associated with thrombosis. Herein, we report identification of two novel classes of factor XIIa inhibitors. The first one is triazolopyrimidine derivatives designed on the basis of the literature aminotriazole hit and identified using virtual screening of the focused library. The second class is a spirocyclic furo[3,4‐c]pyrrole derivatives identified by virtual screening of a large chemical library of drug‐like compounds performed in a previous study but confirmed in vitro here. In both cases, the prediction of inhibitory activity is based on the score of the SOL docking program, which uses the MMFF94 force field to calculate the binding energy. For the best ligands selected in virtual screening of the large chemical library, postprocessing with the PM7 semiempirical quantum‐chemical method was used to calculate the enthalpy of protein‐ligand binding to prioritize 16 compounds for testing in enzymatic assay, and one of them demonstrated micromolar activity. For triazolopyrimidine library, 21 compounds were prioritized for the testing based on docking scores, and visual inspection of docking poses. Of these, 4 compounds showed inhibition of factor XIIa at 30 μM.
Exploring the factors relating to academic resilience among students with socioeconomic disadvantages: Factors from individual, school, and family domains
Authors: Cui Tianxue , Kam Chester Chun Seng , Cheng Emily Hongzhen , Liu Qimeng 
Published: November 2022

AbstractThis study aimed to explore factors related to academic success (resilience) for students with socioeconomic disadvantages (SED) from the individual, school, and family domains. We also compared such factors with the results for students with socioeconomic advantages (SEA). A sample of 1767 eighth‐graders (851 students with SEA and 916 students with SED) from a city in northern China completed the questionnaires online. We found that (a) the common factors related to academic success for students with SED and SEA are high educational expectations, intrinsic motivation, positive parent−child relationships, and schools with high socioeconomic status; and (b) the unique factors for students with SED (but not SEA) are appropriate parental involvement with more concern in daily life but less concern in study and close peer relationships. Findings highlight social support as a protective factor against academic failure, especially among students from low‐income families.
The shift in the laminar‐to‐turbulent transition flow mode in atmospheric pressure plasma jet
Authors: Mohamed Abdel‐Aleam H. , Fadhlalmawla Sahar A. , Almarashi Jamal Q. M. 
Published: November 2022

AbstractNonthermal equilibrium atmospheric pressure plasma jet gained great interest due to its multidisciplinary applications. This work is focused on studying the characteristics of an argon atmospheric pressure plasma jet and the laminar‐to‐turbulent flow mode transition. By increasing the applied voltage from 10 to 25 kV, the plasma can run in four operational modes depending on the number of current pulses per half a cycle of the applied voltage. The plasma jet gas temperature increases from 310 to 370 K and the laminar‐to‐turbulent transition value shifts toward lower flow rate values from 3.75 to 2.6 slpm as a result of increasing the applied voltage. A clear border between the laminar and the turbulent regions has been resolved at different applied voltages and flow rates at a fixed applied frequency of 24 kHz.
Carbon allocation in cassava is affected by water deficit and potassium application – A 13C‐CO2 pulse labelling assessment
Authors: Van Laere Jonas , Willemen Annemie , De Bauw Pieterjan , Hood‐Nowotny Rebecca , Merckx Roel , Dercon Gerd 
Published: November 2022

RationaleCassava production faces challenges in a changing climate. Pulse labelling cassava with 13C‐CO2 has the potential to elucidate carbon allocation mechanisms of cassava under drought stress and with potassium application. Understanding these mechanisms could guide efforts to mitigate effects of drought in cassava cropping systems.MethodsForty‐eight cassava plants received a nutrient solution high or low in potassium. Water deficit was imposed on half of the plants at bulk root initiation stage, after which they were labelled for 8 h with 13C‐CO2 in a 15 m3 growth chamber. Plants were harvested 8 h, 9 days and 24 days after labelling, and separated into leaves, stems and roots. δ13C values of the different parts were measured using an isotope ratio mass spectrometer, from which 13C excess was calculated.ResultsWater deficit decreased transpiration (P < 0.001) and increased carbon respiration (P < 0.05). Potassium application increased assimilate distribution to the roots (P < 0.05) at 9 days after labelling, more strongly for plants under water deficit. The opposite was found at 24 days (P < 0.05) with the legacy of water deficit additionally increasing assimilate distribution to roots (P < 0.05). Youngest, fully expanded leaves contained up to 47% of initial 13C excess at 24 days after labelling.ConclusionsPulse labelling proved to be successful in shedding light on carbon allocation in relation to water and potassium availability. This technique, once adapted to field conditions, could further be used to improve fertilizer recommendations or change agronomic practices to cope with plant stress.
Using Construction‐Integration Theory to Interpret Reading Comprehension Instruction for Students with Autism Spectrum Disorder: A Systematic Review and Meta‐Analysis
Authors: Zhang Shuai , Prykanowski Debra A. , Koppenhaver David A. 
Published: November 2022

AbstractMore than 800,000 students with autism spectrum disorder (ASD) are served in U.S. public schools, a number that has increased annually for almost 20 years since Individuals with Disabilities Education Act (IDEA) included ASD as an eligibility category. These students often experience widespread and persistent reading comprehension challenges. A systematic review and meta‐analysis, anchored in a construction‐integration model of reading comprehension, was undertaken to examine single‐subject research design (SSRD) and group design studies aimed at remediating reading comprehension challenges in students with ASD. Reading comprehension instruction was operationalized by surface, textbase, and situation model levels. Random effect modeling with robust standard error estimations suggested small yet statistically significant intervention effects. Situation model‐level interventions demonstrated the highest intervention effects in group design studies. Across designs, retelling and curriculum‐based question‐answering measures demonstrated larger effect sizes than cloze and norm‐referenced measures. Methodological quality analysis suggested that few individual SSRD and group studies had high design quality with large intervention effects. We concluded that reading comprehension instruction focused on the situation model level should be prioritized for students with ASD, and future studies should reduce bias in designing intervention studies.
Evaluation of Catalytic Performance of Hierarchical Zeolites in Friedel‐Crafts Fixed‐bed Alkylation
Authors: Leng Kunyue , Ren Yu , Wang Wei , Wang Ruisi , Gao Kaiye , Li Xiaolin 
Published: November 2022

AbstractFriedel‐Crafts alkylation is one of the most important catalytic reactions in organic chemistry. Recently, hierarchical zeolites have exhibited superior catalytic performance in such liquid‐phase batch reactions. However, for practical application, it is of significance to evaluate their catalytic performance in Friedel‐Crafts fixed‐bed alkylation. In this work, we prepare hierarchical zeolites by post‐treatment, of which the structures are confirmed by XRD patterns and N2 adsorption‐ desorption tests. Then, a fixed‐bed reactor is employed to investigate their catalytic performance in series of benzylation reactions. The results indicate that hierarchical zeolites have superior anti‐deactivation ability in the benzylation reactions, especially when react with p‐xylene or mesitylene, the BA conversion maintained nearly 100 % in 300 min, much better than that of micropore zeolites. These results suggest that hierarchical zeolites have a potential industrial application for Friedel‐Crafts fixed‐bed alkylation than conventional zeolites.
Direct Sulfonylation of Alkenes with Sulfonyl Chlorides Employing Visible Light Photocatalyst
Authors: Hosseini‐Sarvari Mona , Keshavarz Kimia 
Published: November 2022

AbstractDirect synthesis of vinyl sulfones from alkenes and sulfonyl chlorides through a visible‐light‐induced photocatalytic approach has been developed. According to our research, nano Cu2O/TiO2 was well‐established in photocatalytic processes and now it was shown to be more efficient in the mentioned reaction and also opened up new routes for photocatalysis reactions. Moreover, the semiconductors and their composites such as nano Cu2O/TiO2 surpassed commonly used ruthenium, iridium, or organic dye‐based photocatalysts, because of their economic efficiency and high efficiency in absorbing visible light. In the present study, nano Cu2O/TiO2 as a photocatalyst proceeded with the reaction at room temperature under white LED illumination and air atmosphere. High eco‐sustainability, low cost, and ease of operation are all essential characteristics of the created method.
Bubbles Templated Interconnected Porous Metallic Materials: Synthesis, Surface Modification, and their Electrocatalytic Applications for Water Splitting and Alcohols Oxidation
Authors: Arshad Farhan , Tahir Aleena , Haq Tanveer Ul , Munir Akhtar , Hussain Irshad , Sher Falak 
Published: November 2022

AbstractPorous metallic foams play a vital role in a diverse range of applications including electrocatalysis, electrochemical sensing, energy conversion and storage systems. Recently, template‐free electrochemical deposition or dynamic bubbles templating techniques have been very useful to precisely control the nanostructured metallic architecture without using any additional organic or inorganic template. Dynamic hydrogen/oxygen bubbles template electrodeposited metallic foams give micro/nano porosity with controlled pores size, pores channels and surface decorated nanoparticles. In this review, we describe the uniqueness of bubble‐templating electrochemical deposition techniques, their detailed implementation towards the synthesis of novel nanostructured metallic foam, and the progress made in the field of hydrogen bubbles, oxygen bubbles, and their derived templating approaches for the development of advanced nanometallic foam and their future prospective. Some modifications of porous metallic foams by galvanic replacement, chemical/electrochemical dealloying process, annealing and decoration of metallic and non‐metallic composites on the porous metallic foam are also summarized. Moreover, the role of porous metallic foam in electrochemical water splitting and alcohol oxidation reaction by offering a short diffusion pathway and concluding remarks about the recent development and future perspective of porous foam in the frontiers of surface structure are also critically reviewed.
Fly‐Ash‐Based Hierarchical MCM‐41 Molecular Sieve as an Efficient Adsorbent for Methylene Blue Removal from Wastewater over a Wide pH
Authors: Zhang Huabing , Gan Simeng , Sun Houxiang , Yang Haiyan , Xie Sicai 
Published: November 2022

AbstractThe development of cost‐effective adsorbents with high sorption capacity and excellent renewability over a wide range of pH is essential for removal of toxic methylene blue (MB) from wastewater. The micro‐mesoporous MCM‐41 molecular sieve (M–MCM‐41) was prepared by coal fly ash (CFA). The low temperature N2 physical adsorption reveals that the prepared M–MCM‐41 has hierarchically micro‐mesoporous structure with high surface area (909.5 m2⋅g−1). As a result, M–MCM‐41 possesses superior adsorption presentation towards MB with prominently high sorption capacity of 574.7 mg⋅g−1, and rapid sorption rate of 0.29 g⋅mg−1⋅h −1 (13 fold that of CFA). Surprisingly, 95 % of the incipient adsorption capacity remains well after five cycles. More importantly, the M–MCM‐41 maintains almost the same maximum sorption capacity in the pH range of 5–9, which is close to the wastewater discharge standard (6∼9) without excessive pH adjustment. The adsorption kinetics and equilibrium data fit well with pseudo‐second‐order model and the Langmuir isotherm model, respectively. And the thermodynamic investigations show that the adsorption behavior is spontaneous and exothermic. The M–MCM‐41 has well‐defined micro‐mesoporous porosity and could be used as an effective adsorbent to remove MB from wastewater. This work provides a new sight for the solid waste resource utilization, which is beneficial to the development of recycling economy.