bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using practice facilitation to improve alcohol-related care in primary care: a mixed-methods pilot study protocol
Authors: Bachrach Rachel L. , Chinman Matthew , Rodriguez Keri L. , Mor Maria K. , Kraemer Kevin L. , Garfunkel Cécile E. , Williams Emily C. 
Published: March 2022

Abstract
Background
Alcohol use is a significant risk factor for disability and death in U.S. adults, and approximately one out of every six Veterans seen in primary care (PC) report unhealthy alcohol use. Unhealthy alcohol use is associated with increased risk for poor medical outcomes, substantial societal costs, and death, including suicide. Based on substantial evidence from randomized controlled trials and the U.S. Preventive Services Task Force, VA/DoD clinical guidelines stipulate that all Veterans screening positive for unhealthy alcohol use should receive evidence-based alcohol care in PC, including brief counseling interventions (BI) and additional treatment (e.g., pharmacotherapy) for those with alcohol use disorders (AUD). The VA pioneered implementing alcohol screening and BI in PC, yet substantial implementation gaps remain. To improve alcohol-related care, this study will conduct a pilot study to assess whether a multi-faceted evidence-based implementation strategy—practice facilitation—has the potential to improve PC-based alcohol-related care at a single VA clinic.

Methods
We will first recruit and conduct qualitative interviews with Veterans with unhealthy alcohol use (n = 20–25) and PC stakeholders (N = 10–15) to understand barriers and facilitators to high-quality alcohol care and use results to refine and hone the multifaceted practice facilitation intervention. Qualitative interviews, analysis, and refinement of the intervention will be guided by the Consolidated Framework for Implementation Research (CFIR). Focus groups with a small sample of PC providers and staff (n = 5–7) will be used to further refine the practice facilitation intervention and assess its acceptability and feasibility. The refined practice facilitation intervention will then be offered in the PC clinic to assess implementation (e.g., reach) and effectiveness (reduced drinking) outcomes based on the RE-AIM framework.

Discussion
This research directly addresses one of the largest public health crises of our time, as alcohol kills more people than opioids and is associated with increased risk of suicide. If successful, this pilot may generate an intervention with far-reaching effects on adverse outcomes experienced by Veterans with unhealthy alcohol use, including increased access to care and suicide prevention.
Trial registration Clinicaltrials.gov identifier: NCT04565899; Date of registration: 9/25/2020
Precise activity measurements of medical radionuclides using an ionization chamber: a case study with Terbium-161
Authors: Juget Frédéric , Talip Zeynep , Nedjadi Youcef , Durán M. Teresa , Grundler Pascal V. , Zeevaart Jan Rijn , van der Meulen Nicholas P. , Bailat Claude 
Published: March 2022

Abstract
Background
161Tb draws an increasing interest in nuclear medicine for therapeutic applications. More than 99% of the emitted gamma and X-rays of 161Tb have an energy below 100 keV. Consequently, precise activity measurement of 161Tb becomes inaccurate with radionuclide dose calibrators when using inappropriate containers or calibration factors to account for the attenuation of this low energy radiation. To evaluate the ionization chamber response, the sample activity must be well known. This can be performed using standards traceable to the Système International de Référence, which is briefly described as well as the method to standardize the radionuclides.

Methods
In this study, the response of an ionization chamber using different container types and volumes was assessed using 161Tb. The containers were filled with a standardized activity solution of 161Tb and measured with a dedicated ionization chamber, providing an accurate response. The results were compared with standardized solutions of high-energy gamma-emitting radionuclides such as 137Cs, 60Co, 133Ba and 57Co.

Results
For the glass vial type with an irregular glass thickness, the 161Tb measurements gave a deviation of 4.5% between two vials of the same type. The other glass vial types have a much more regular thickness and no discrepancy was observed in the response of the ionization chamber for these type of vials. Measurements with a plastic Eppendorf tube showed stable response, with greater sensitivity than the glass vials.

Conclusion
Ionization chamber measurements for low-energy gamma emitters (< 100 keV), show deviation depending on the container type used. Therefore, a careful selection of the container type must be done for activity assessment of 161Tb using radionuclide dose calibrators. In conclusion, it was highlighted that appropriate calibration factors must be used for each container geometry when measuring 161Tb and, more generally, for low-energy gamma emitters.
Conversion surgery for undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a case report
Authors: Igarashi Yosuke , Gocho Takeshi , Taniai Tomohiko , Uwagawa Tadashi , Hamura Ryoga , Shirai Yoshihiro , Yasuda Jungo , Haruki Koichiro , Furukawa Kenei , Ikegami Toru 
Published: March 2022

Abstract
Background
Undifferentiated carcinoma with osteoclast-like giant cells (UCOGCs) is a rare subtype of pancreatic cancer (PC), and its clinicopathological characteristics are still unclear. Herein, we report a case of initially unresectable UCOGC that was successfully resected after FOLFIRINOX therapy.

Case presentation
A 63-year-old man was referred to us for evaluation of a pancreatic mass detected by computed tomography (CT) during a medical checkup. Computed tomography showed a 7.5-cm tumor located in the pancreatic head and body, which involved the common hepatic artery (CHA), gastroduodenal artery (GDA), and main portal vein (PV) with tumor thrombus. UCOGC was suspected by endoscopic ultrasonography-guided fine needle aspiration, and the patient was diagnosed with unresectable locally advanced pancreatic cancer. After ten cycles of FOLFIRINOX, the tumor size decreased to 3 cm and the tumor thrombus in the main portal trunk had disappeared in the follow-up CT scan. However, the patient experienced severe adverse drug reactions, including neutropenia and liver dysfunction. Therefore, we performed pancreatoduodenectomy with portal vein resection. The pathological diagnosis was UCOGC with a negative tumor margin. He was treated with FOLFIRINOX, and remains recurrence-free for 6 months after surgery.

Conclusions
We experienced a case undergoing conversion surgery for unresectable UCOGC, which resulted in R0 resection. FOLFIRINOX could be a possible regimen to achieve conversion surgery for UCOGC.
Efficacy of non-obstructive aortic angioscopy for detecting a thoracic aortic graft rupture: a case report
Authors: Yamana Fumio , Maeda Koichi , Hamanaka Yuma , Kodani Noriko , Domae Keitaro , Hata Masatoshi , Higuchi Yoshiharu , Shirakawa Yukitoshi , Masai Takafumi 
Published: March 2022

Abstract
Background
Non-anastomotic thoracic aortic graft rupture is extremely rare and difficult to diagnose. Non-obstructive general angioscopy can help monitor the aortic intima and detect the locations of abnormal findings, while aortic angioscopy can detect vulnerable plaques in the aorta, which are difficult to visualize using conventional diagnostic methods. Herein, we report the case of a patient with non-anastomotic thoracic aortic graft rupture diagnosed using non-obstructive aortic angioscopy.

Case presentation
An 85-year-old man who had undergone total arch replacement 5 years prior complained of chest pain. Emergent contrast-enhanced computed tomography (CT) revealed an intra-mediastinal hematoma around the vascular graft of the ascending aorta and angiography revealed pooling of contrast medium on the dorsal side of the vascular graft. We suspected extravasation of the thoracic vascular graft. Aortic angioscopic examination revealed a red vascular graft defect that matched extravasation at the contralateral level of the prosthetic left common carotid artery branch. Subsequently, non-anastomotic thoracic aortic graft rupture was diagnosed. The patient underwent a two-debranching thoracic endovascular aortic repair (Zone 0) with a right subclavian artery-left common carotid artery-left subclavian artery bypass. Postoperative angiography revealed disappearance of the extravasation from the graft rupture site, patent grafted vessels with flow, and no endoleak. Follow-up CT at 6 months postoperatively showed no extravasation.

Conclusions
To our knowledge, this is the first report of non-anastomotic thoracic aortic graft rupture detected using non-obstructive aortic angioscopy. Aortic angioscopy can help establish a definitive diagnosis in patients with aortic graft rupture.
Sensing Technology for Assessing Motor Behavior in Ballet: A Systematic Review
Authors: Quadrado Virginia , Moreira Margarida , Ferreira Hugo , Passos Pedro 
Published: March 2022

AbstractBackgroundHuman performance in classical ballet is a research field of growing interest in the past decades. Technology used to acquire data in human movement sciences has evolved, and is specifically being applied to evaluate ballet movements to better understand dancers’ profiles. We aimed to systematically review sensing technologies that were used to extract data from dancers, in order to improve knowledge regarding the performance of ballet movements through quantification.MethodsPubMed, MEDLINE, EMBASE, and Web of Science databases were accessed through 2020. All studies that used motor control tools to evaluate classical ballet movements, and possible comparisons to other types of dance and sports movements were selected. Pertinent data were filled into a customized table, and risk of bias was carefully analyzed.ResultsEighty studies were included. The majority were regarding classical ballet and with pre-professional dancers. Forty-four studies (55%) used two or more types of technology to collect data, showing that motion capture technique, force plates, electromyography, and inertial sensors are the most frequent ways to evaluate ballet movements.DiscussionResearch to evaluate ballet movements varies greatly considering study design and specific intervention characteristics. Combining two or more types of technology may increase data reliability and optimize the characterization of ballet movements. A lack of studies addressing muscle–brain interaction in dancers were observed, and given the potential of novel insights, further studies in this field are warranted. Finally, using quantitative tools opens the perspective of defining what is considered an elite dancer.
Periodic hypersomnolence in a young female patient: a case report and literature review
Authors: Alemohammad Zahra Banafsheh , Jamshidi Sajedeh , Najafi Arezu 
Published: March 2022

Abstract
Background
Kleine–Levin syndrome (KLS) is a disease with periodic hypersomnolence accompanied by abnormal behavior with a rare prevalence in female.

Case presentation
Here, we report a young lady with chief complaint of hypersomnolence for 6 years of visits and any history of sleep attack, sleep paralysis, and cataplexy. Polysomnography was performed for the patient. The respiratory disturbance index was normal. In MSLT the patient had two SOREMs with mean sleep latency of 7 min. She was diagnosed as Kleine–Levin syndrome as the sleepiness symptoms had a periodic pattern without other characteristics of central hypersomnolence disorders. The patient did not report behavioral characteristics of KLS reported in previous literature. She improved spontaneously after a while in follow-ups without any further treatment.

Conclusions
Although KLS is reported rarely in female gender and there are previous defined behavioral symptoms for this syndrome, periodic pattern of sleepiness should raise this diagnosis after exclusion of other hypersomnolence causes.
A comparative study between ultrasound-guided ilioingunial/iliohypogastric nerve block versus transverse abdominis plane block in patients undergoing oblique inguinal hernia repair
Authors: Elwany Ahmed Fathi , Mohamed Sohair Abass , EL-Fatah Amr Mohamed Abd , El-sayed Nasser El-sayed , Samir Ghada Mohamed 
Published: March 2022

Abstract
Background
Combined ilioinguinal-iliohypogastric (IIN/IHN) block and transverse abdominis plane (TAP) block are used under ultrasound (USG) visualization for postoperative pain control in patients undergoing inguinal hernia repair surgery. This study compares USG-guided TAP versus IIN/IHN block for post-operative analgesia efficacy in adults undergoing inguinal hernia surgery, among 100 patients randomized into group A received TAP block by using levobupivacaine 0.5% 25 ml and group B received IIN+IHN blocks by using levobupivacaine 0.5% 10 ml before induction of general anesthesia.

Results
The mean duration (in minutes) to require rescue analgesia was found to be 1003.2 ± 99.6 (min) in group A and 1317 ± 69 (min) in group B. In a comparison of these two values the difference in the meantime to rescue analgesic requirement was statistically significant (p < 0.001).

Conclusions
USG-guided IIN/IHN block delays the need for rescue analgesia and reduces the postoperative analgesic requirement compared to USG-guided TAP block.
Bacterial communities in the gastrointestinal tract segments of helminth-resistant and helminth-susceptible sheep
Authors: Paz Erwin A. , Chua Eng Guan , Hassan Shamshad Ul , Greeff Johan C. , Palmer Dieter G. , Liu Shimin , Lamichhane Binit , Sepúlveda Néstor , Liu Junhua , Tay Chin Yen , Martin Graeme B. 
Published: March 2022

Abstract
Background
Helminth parasitism is a world-wide problem in livestock industries, with major impacts on health, welfare and productivity. The role of the gut microbiota in host-helminth interactions in ruminants has been extensively examined and the present study added to this body of knowledge by assessing the effects of resistance and susceptibility to helminth infection in the gastro-intestinal tract (GIT). Australian Sheep Breeding Values (ASBVs) for faecal egg count (FEC) were used to select the 10 highly helminth-susceptible (High-FEC) and 10 highly helminth-resistant (Low-FEC) sheep. FEC status was confirmed during the experiment. Using samples from the faeces and the lumen of the rumen, abomasum, duodenum, jejunum, ileum, caecum, and colon, DNA was extracted and used for 16 rRNA gene amplicon sequencing.

Results
The most frequent genera identified along the GIT were Eubacterium, Oscillibacter, and Ruminococcus. Intersectoral-specialization zones were identified along the GIT, with the duodenum displaying major differences between the High-FEC and Low-FEC animals in values for alpha and beta diversity. After taking all samples into account and adjusting for GIT segment, the High-FEC and Low-FEC sheep differed significantly for four genera Butyrivibrio, Mycoplasma, Lachnoclostridium and Succiniclasticum. In the duodenum, the abundances of Aminipila, Lachnoclostridium and Mogibacterium differed significantly between the High-FEC and Low-FEC sheep. In the ileum, on the other hand, the genus Mycoplasma was significantly depleted in the Low-FEC group.

Conclusions
The gastro-intestinal microbial profile varies widely between helminth-resistant and helminth-susceptible sheep. Each GIT section appears to support a particular bacterial composition leading to inter-sectoral differences among the various microbial communities. The microbial populations were most rich and diverse in the duodenum of helminth-resistant sheep, comprising bacterial genera that generally ferment carbohydrates. This observation suggests that helminth-resistant sheep can reorganize the duodenal microbiome taxa which may restrict the development of parasites.
The life-cycle assessment of greenhouse gas emissions and life-cycle costs of e-waste management in Thailand
Authors: Mangmeechai Aweewan 
Published: March 2022

AbstractThere is no clear direction in the management of electrical and electronic waste products (e-waste), as there are no regulations on ways to do so. This research attempts to understand the trade-off between the economic value and the environmental effects of the current disposal of e-waste to find ways to optimize waste management, focusing on cellphones, television cathode ray tubes, desktop computers, and air conditioners. A life cycle greenhouse gas and life cycle costs were conducted. Under the e-waste management status quo, most household e-waste is kept in houses because owners do not know where to discard it. In addition, informal sectors, such as domestic farmers or workers, have been actively involved in collecting and dismantling e-waste for more than a decade, leading to poor management standards for both health and the environment. Without e-waste management regulations, informal dismantlers of products gain slight profits by collecting and selling parts and discarding all non-recyclable waste in municipal garbage dumps. The current practice actually adds greenhouse gas to the atmosphere mainly due to improper logistics management and discarding of refrigerants. The logistics are inefficient because the dismantling communities and recycling locations are far apart. Most e-waste is generated, and most recycling industries are located in the central region (the richest areas), while the dismantling communities are located in the northeastern region (the poorest areas). Furthermore, the life cycle of greenhouse gas and the life cycle costs of e-waste are affected by transportation, and not all e-waste parts can be recycled within the country. High-tech mineral extraction cannot be practiced in the country, and thus, circuit boards and batteries are exported for recycling. To promote a circular economy, e-waste management regulations should be implemented, the costs of proper e-waste management should be internalized, and a full recycling industry should be established in the country.
Principle and performance of BDSBAS and PPP-B2b of BDS-3
Authors: Yang Yuanxi , Ding Qun , Gao Weiguang , Li Jinlong , Xu Yangyin , Sun Bijiao 
Published: March 2022

AbstractWithin the framework of differential augmentation, this paper introduces the basic technical framework and performance of the BeiDou Global Navigation Satellite System (BDS-3) Satellite-Based Augmentation System (BDSBAS), including orbit products, satellite clock offset products, ionosphere and its integrity performance. The basic principle of BDS-3 Precise Point Positioning (PPP-B2b) is expounded, the similarities and differences between the PPP service provided by BDS-3 and International Global Navigation Satellite System (GNSS) Service (IGS) are discussed, and the limitations of PPP-B2b are analyzed. Since both the BDSBAS and PPP-B2b utilize a ground monitoring station network to determine the satellite orbits and clock offset corrections, and broadcast differential corrections through the three Geostationary Orbit (GEO) satellites of BDS-3, the feasibility of the co-construction of BDSBAS and PPP-B2b is analyzed, strategies for the infrastructure sharing and correction broadcasting are presented, and the influences of BDSBAS correction broadcasting strategy adjustment are evaluated. In addition, it assesses the possibility of broadcasting differential corrections through the Inclined Geosynchronous Orbit (IGSO) satellites of BDS-3, and the feasibility of augmenting satellite navigation with Low Earth Orbit (LEO) satellites.
A study of nasal epithelial cell gene expression in a sample of mild to severe asthmatic children and healthy controls
Authors: Behairy Ola Galal Ali , Mohammad Osama Ibrahim , Salim Rabab F. , Sobeih Ahmad Ata 
Published: March 2022

Abstract
Background
Airway epithelium contributes to the natural history of bronchial asthma through the production of various cytokines and chemokines. The purpose of this study was to assess nasal epithelial cell genes (TMEM178, FKBP5, CLCA1, SERPINB2 and periostin) in childhood asthma and their utility in predicting asthma severity, and atopic status. Seventy asthmatic children were included and further subdivided into mild, moderate and severe persistent asthma together with 30 apparently healthy children as a control group. All children were subjected to medical history taking, clinical examination. Nasal epithelial samples were collected for detection of epithelial cell genes (TMEM178, FKBP5, CLCA1, SERPINB2 and periostin) by real-time PCR.

Results
TMEM178 showed significant down-regulation in asthmatic children and its expression levels decreased significantly with the progression of asthma severity. CLCA1, SERPINB2 and periostin showed statistically significant up-regulation in asthmatic children, whereas FKBP5 was increased in asthmatic children but with non-significant up-regulation when compared with the control group. Regarding atopic status, relative gene expression levels of CLCA1, SERPINB2 and periostin were significantly up-regulated in atopic asthma.

Conclusion
Our findings suggest the role of nasal airways epithelial cells in predicting asthma severity and atopic status, as TMEM178 expression gained attention as a predictor of asthma severity. CLCA1, SERPINB2 and periostin expression were up-regulated not only in asthmatic children, but also in atopic asthma.
Momordica charantia nanoparticles potentiate insulin release and modulate antioxidant gene expression in pancreas of diabetic rats
Authors: Elekofehinti Olusola Olalekan 
Published: March 2022

Abstract
Background
Green synthesis of nanoparticles with medicinal plants has inherent potential in the management of diabetes mellitus. This study synthesized Momordica charantia nanoparticles using silver nitrate to investigate the antidiabetic properties of this extract and the synthesized nanoparticles in vivo.

Results
The M. charantia nanoparticles used were synthesized biologically under ambient conditions from methanolic leaf extract of M. charantia using 1 mM concentration of aqueous silver nitrate and characterized using spectroscopic methods, FTIR and scanning electron microscopy. In vivo, the antidiabetic activity of M. charantia nanoparticle was assessed in streptozotocin-induced (65 mg/kg) rats. Rats were treated with M. charantia nanoparticle (50 mg/kg), aqueous leaf extract (100 mg/kg) metformin (100 mg/kg) and silver nitrate nanoparticle (10 mg/kg) for 21 days. Following treatment, rats were killed for biochemical analysis. Also, reverse transcript-polymerase chain reaction analyses of Takeda-G-protein-receptor-5, glucagon-like peptide-1, Insulin, superoxide dismutase, catalase and Nuclear factor-erythroid factor 2-related factor 2 (NRF2) - were carried out in the pancreas. A significant reduction in blood sugar levels was noted in rats treated with M. charantia nanoparticles. A reduction (p < 0.05) of pancreas alanine transaminase, aspartate aminotransferase and alkaline phosphatase was observed when compared with diabetic untreated rats. M. charantia nanoparticles significantly increase the antioxidant enzymes in diabetic rats when compared with diabetic untreated rats. The decrease in the level of triglyceride, cholesterol and low-density lipoprotein was observed when compared with diabetic control rats and also a significant increase in the expression of Takeda-G-protein-receptor-5, glucagon-like peptide-1, insulin, superoxide dismutase, catalase and NFE2-related factor 2 genes was observed when compared with diabetic untreated rats.

Conclusions
Momordica charantia nanoparticles exhibited potential antidiabetic activity in the rat model of diabetes and thus may serve as a therapeutic agent that could be developed for medical applications in the future.