bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foxi3 Suppresses Signaling Center Fate and is Necessary for the Early Development of Mouse Teeth
Authors: Mogollón Isabel , Kangasniemi Niko , Moustakas-Verho Jacqueline Emmanuel , Ahtiainen Laura 
Published: July 2022

AbstractTooth morphogenesis is regulated by ectodermal-mesenchymal interactions which are controlled by reiteratively used, evolutionarily conserved pathways. How these signals translate into different cellular behaviors is beginning to be understood. Embryonic cell behaviors are regulated by signaling centers that define organ position, size, and shape. The recently identified initiation knots (IKs) and the well-known enamel knots (EK) are tooth epithelial signaling centers that drive proliferation of the neighboring cells and are involved at different stages of morphogenesis, from the early epithelial thickening to the final formation of shape. Signaling center cell fate and maintenance can be regulated by numerous factors. Here, we studied the early stages of murine incisor and molar epithelial morphogenesis and overcame the previous shortage of early-stage mutant models to functionally manipulate the initiation processes of tooth morphogenesis. We achieved the early conditional knock down of the forkhead-box transcription factor Foxi3 during tooth initiation and used imaging approaches to explore cellular and molecular disease mechanisms, specifically those related to signaling center dysfunction in tooth dysplasia. We show that early deficiency of Foxi3 in incisors and molars frequently arrests growth at bud stage, whereas later knockdown of Foxi3 affects tooth downgrowth and shape. Cell-level analyses revealed a decrease in epithelial proliferation and the ectopic appearance of cells with hallmarks of signaling centers: quiescent cell state and canonical Wnt activity. However, the distribution of these cells was wider all over the tooth buds with abnormal decrease of apoptosis. We postulate that, depending on Foxi3 expression levels, the bud cells shift commitment into signaling center fate, ultimately leading to growth arrest or growth/shape changes, implicating Foxi3 as a regulator of cell fates between the signaling centers and proliferating bud cells.
A highly multiplexed assay to monitor pathogenicity, fungicide resistance and gene flow in the fungal wheat pathogenZymoseptoria tritici
Authors: Bellah Hadjer , Gazeau Gwilherm , Gélisse Sandrine , Amezrou Reda , Marcel Thierry C. , Croll Daniel 
Published: July 2022

AbstractCrop pathogens pose severe risks to global food production due to the rapid rise of resistance to pesticides and host resistance breakdowns. Predicting future risks requires monitoring tools to identify changes in the genetic composition of pathogen populations. Here we report the design of a microfluidics-based amplicon sequencing assay to multiplex 798 loci targeting virulence and fungicide resistance genes, and randomly selected genome-wide markers for the fungal pathogenZymoseptoria tritici. The fungus causes one of the most devastating diseases on wheat showing rapid adaptation to fungicides and host resistance. We optimized the primer design by integrating polymorphism data from 632 genomes of the same species. To test the performance of the assay, we genotyped 192 samples in two replicates. Analysis of the short-read sequence data generated by the assay showed a fairly stable success rate across samples to amplify a large number of loci. The performance was consistent between samples originating from pure genomic DNA as well as material extracted directly from infected wheat leaves. In samples with mixed genotypes, we found that the assay recovers variations in allele frequencies. We also explored the potential of the amplicon assay to recover transposable element insertion polymorphism relevant for fungicide resistance. As a proof-of-concept, we show that the assay recovers the pathogen population structure across French wheat fields. Genomic monitoring of crop pathogens contributes to more sustainable crop protection and yields.
Auditor characteristics and the financial reporting quality: the moderating role of the client business strategy
Authors: Soroushyar Afsaneh 
Published: July 2022

PurposeThis study examines whether and how a client's business strategy can affect the relationship between auditor characteristics and financial reporting quality.Design/methodology/approachIn this study, auditor industry specialization and tenure were used as proxies for auditor characteristics. The client business strategy was measured using the resource allocation index method. Finally, discretionary accruals are used to assess financial reporting quality. This study includes 1,450 firm-year observations and 145 companies listed on the Tehran Stock Exchange (TSE) over a ten-year period from 2011 to 2020. The research hypotheses were analyzed using a multivariate regression model and panel data.FindingsThe results show that auditor industry specialization increases financial reporting quality. This relationship improves when the client's business strategy deviates from the industry–normal strategy. The research findings state that auditor tenure has a positive association with financial reporting quality, and this relationship is strengthened when the company's business strategy deviates from the normal industry strategy.Practical implicationsThe findings of this study provide important evidence for investors, firm management, and auditing firms. Investors must consider the auditor characteristics when selecting companies listed on the TSE. Managers of Iranian companies are advised to consider the auditor's characteristics when choosing an audit firm to increase financial reporting quality. Audit firms should evaluate their business strategies in audit planning to increase the quality of financial reporting.Originality/valueTo the best of the authors’ knowledge, this is the first empirical study to examine the relationship between auditor characteristics and the financial reporting quality in the emerging capital market by considering the clients' business strategy.
Digitalization in corporate communications: understanding the emergence and consequences of CommTech and digital infrastructure
Authors: Brockhaus Jana , Buhmann Alexander , Zerfass Ansgar 
Published: July 2022

PurposeThis article studies the digitalization of corporate communications and the emergence of communication technology (CommTech). The authors show communicators' expectations regarding digitalization, gauge the current level of digitalization across communication departments and agencies and examine the effectiveness of strategic approaches to manage digitalization.Design/methodology/approachThe authors conceptualize the phenomenon of CommTech and propose a framework for studying CommTech's emergence and consequences by combining (1) recent theorizing on digitalization in corporate communications, (2) the concept of digital maturity from information systems research and (3) a socio-technical approach to analyze the development of work systems. The authors apply this framework in a quantitative study (n = 2,664) among communication practitioners from 46 countries.FindingsWhile digitalization of both communication activities and the underlying support infrastructure is seen as critically important among communicators, a large fraction of communication departments and agencies are still assessed as digitally immature. Further, data reveal the relevance of different (technology, tasks, structure and people) dimensions of digitalization strategies and the influence of such strategies on the digital maturity of communications.Practical implicationsThe framework and empirical instruments developed in this study help practitioners to uncover and evaluate the level of digital maturity of communication departments and agencies. This allows to identify current challenges and future opportunities for improvement.Originality/valueThe authors propose a concise definition for the much-debated concept of CommTech and develop a new theoretical framework for understanding CommTech's emergence and consequences in the profession. This empirical work constitutes the first large-scale study on the digital maturity of communication departments and agencies.
Parallel-in-space-and-time finite-element analysis of electric machines using time step overlapping in a massively parallel computing environment
Authors: Takahashi Yasuhito , Fujiwara Koji , Iwashita Takeshi 
Published: July 2022

Purpose
This study aims to enhance the parallel performance of a parallel-in-space-and-time (PinST) finite-element method (FEM) using time step overlapping. The effectiveness of the developed method is clarified in a magnet eddy-current loss analysis of a practical interior permanent magnet synchronous motor (IPMSM) using a massively parallel computing environment.

Design/methodology/approach
The developed PinST FEM is a combination of the domain decomposition method as a parallel-in-space (PinS) method and a parallel time-periodic explicit error correction (PTP-EEC) method, which is one of the parallel-in-time (PinT) approaches. The parallel performance of the PinST FEM is further improved by overlapping the time steps with different processes in the PTP-EEC method.

Findings
By applying the overlapping PTP-EEC method, the convergence of the transient solution to its steady state can be accelerated drastically. Consequently, the good parallel performance of the PinST FEM is achieved in magnetic field analyses of the practical IPMSM using a massively parallel computing environment, in which over 10,000 processes are used.

Originality/value
In this study, the PinST FEM based on time step overlapping is newly developed and its effectiveness is demonstrated in a massively parallel computing environment, in which using either the PinS or PinT method alone cannot achieve sufficient parallel performance. This finding implies a new direction of parallel computing approaches for electromagnetic field computation.
Drivers of digital supply chain transformation in SMEs and large enterprises – a case of COVID-19 disruption risk
Authors: Ngo Vu Minh , Pham Hiep Cong , Nguyen Huan Huu 
Published: July 2022

PurposeDigital transformation in supply chains (SCs) has emerged as one of the most effective ways to minimize SC disruption risks. Given the unprecedented impact of the COVID-19 pandemic on global SCs, this study aims to identify and provide empirical evidence about the drivers of digital SC transformation, considering the interactivity between environmental dynamism, technology, and organizational capabilities during the pandemic era.Design/methodology/approachUsing partial least squares structural equation modeling (PLS-SEM), this study examines 923 firms in Vietnam to ascertain the drivers of digital SC transformation between small- and medium-sized enterprises (SMEs) and large enterprises, based on the technology–organization–environment (TOE) as an overarching framework.FindingsThis study finds that greater digital SC transformation adoption could be achieved under the interactivity between the TOE components of firms' technological competencies, learning capabilities, and disruptions in socioeconomic environments due to the COVID-19 pandemic. Moreover, a multigroup analysis shows that the drivers of digital SC transformation differ between SMEs and large enterprises. SMEs were found to be more motivated by the COVID-19 disruption risk when adopting digital SC models.Originality/valueThis study represents an original and novel contribution from Vietnam as an emerging market to the literature on the impact of COVID-19 on the global value chain. Apart from the unique dataset at the firm level, the analysis of interactions between external and internal drivers of digital SC transformation could provide crucial managerial implications for SMEs to survive major disruptions, such as those caused by the COVID-19 pandemic.
“Managing the “new normal”: the future of operations and supply chain management in unprecedented times”
Authors: Alexander Anthony , Blome Constantin , Schleper Martin C. , Roscoe Samuel 
Published: July 2022

PurposeThe purpose of this article is to discuss the theme of managing operations and supply chains in the so-called “new normal”. It reflects the themes emerging from recent research and how these might be conceptualized.Design/methodology/approachThe article reviews research presented at the EurOMA 2021 conference and eight papers subsequently developed into full journal papers. It considers conceptual themes contained in these papers and how they reflect recent turbulent events in the external business environment.FindingsThe article notes the themes of resilience in relation to the Covid-19 pandemic, environmental sustainability, especially climate change and the Sustainable Development Goals, and the significance of digital technologies. Additional themes relating to inter-organizational relationships, complexity and manager cognition are also considered. In order to provide useful insights for future disruptions, general concepts on epistemology and responsiveness are described.Originality/valueThe article discusses general principles across cutting-edge research in operations and supply chain management, to support improved performance to add economic and social value.
Relationship between ecosystem innovation and performance measurement models
Authors: da Silva Deoclécio Junior Cardoso , Lopes Luis Felipe Dias , Santos Costa Vieira da Silva Luciana , da Silva Wesley Vieira , Teixeira Clarissa Stefani , Veiga Claudimar 
Published: July 2022

PurposeThis study examines the relationship between the innovation ecosystem and performance measurement models. Although the innovation ecosystem and measurement models are widely recognized, the existing literature lacks a comprehensive understanding of the relationship between the proposed themes. Furthermore, it does not reveal how studies can be grouped to propose a thematic typology of the relationship.Design/methodology/approachThe authors present a systematic literature review conducted in the Web of Science and Scopus databases, from a textual corpus that aided the proposition of the typology that aims to provide answers regarding the addressed themes.FindingsThe results of this review are based on a total of sixty peer-reviewed articles from the innovation ecosystem literature and performance measurement models between 1995 and 2020. The results make several contributions to the literature. First, by integrating evidence from empirical studies, the authors identified a typology formed by three classes: (1) ecosystem agents (2) analytical focus and (3) structured measurement tools. Second, the authors verified the relationship between the themes and discovered the existence of gaps to be filled, with the proposition of three drivers. Third, the authors presented a comprehensive mapping of field studies with a descriptive analysis of the textual corpus.Originality/valueThe results of the research provide important implications for researchers, managers and policy makers. Furthermore, the authors suggest directions for future research, including the need to examine the performance of the entire innovation ecosystem, integrating the different agents that exist for performance measurement.
Defining online to offline (O2O): a systematic approach to defining an emerging business model
Authors: Lee Philip Tin Yun , E Feiyu , Chau Michael 
Published: July 2022

PurposeA new business model online to offline (O2O) has emerged in recent years. Similar to many new models at an early stage, O2O has inconsistent definitions which not only inhibit its adoption but also poorly differentiate O2O from other existing business models. To resolve the two issues, the authors propose an approach of definition development.Design/methodology/approachTo show the usefulness of the approach, the authors demonstrate the differences among O2O and other business models with the use of the distinctive definition and thereby evaluate adoption of O2O from a practical perspective and identify research directions from a theoretical perspective based on the differences.FindingsThe authors' proposed approach of definition development integrates the work of Tatarkiewicz (1980) and Nickerson et al. (2013). The approach generates a distinctive definition of O2O with important analytical dimensions which help decision-making of adoption of O2O.Originality/valueThe paper aims to make several contributions. First, on theoretical contribution, the authors confine the scope of O2O studies and facilitate accumulation of more coherent knowledge of O2O. The authors help O2O evolve from a “buzz word” of successful stories in real businesses to a more serious concept from an academic perspective. Second, from a practical perspective, the authors' definition provides business executives with critical evaluative dimensions for gauging the adoption of O2O. Lastly, from a methodological perspective, the proposed approach can be used in future to define an emerging concept in real life businesses.
Dividend payout decisions under uncertainty: the ownership influence in the early days of the COVID-19 pandemic in Finland
Authors: Lindén Andreas , Lehner Othmar M. , Losbichler Heimo , Martikainen Minna 
Published: July 2022

PurposeThis paper examines whether ownership type has a moderating influence on dividend payouts during the COVID-19 pandemic crisis with respect to changes in profits. Future uncertainties because of the pandemic will result in a perceived need for liquidity within the company, but retaining cash may be risky for shareholders who could look for less risky alternatives. The dividend payout strategy is thus even more closely related to the overall type concentration and strategy of the owners during the crisis.Design/methodology/approachThe effects are explored and tested on early data from 2019 to 2020 of Finnish companies using ANCOVA while controlling for profitability and sector variables.FindingsA significant effect on dividend payout during the COVID crisis was found when the companies are dominantly held by individual owners validating early suggestions on such an influence. Therefore, this study contributes further to the academic debates on the influence of ownership concentration in times of crises. This study lists certain sectors which experience diminished profits during such a crisis which pinpoints sector separation in future discussions.Research limitations/implicationsThis study explores early data from a specific context in the Nordic countries. However, it does so out of purpose as explained in the paper.Practical implicationsOwnership type and concentration matters when it comes to dividend payout decisions under uncertainty with regard to changes in profit. Investors need to accept these behavioural insights into their decisions.Originality/valueThis study examines the signalling effect of dividends by analysing how actual or anticipated change in profitability due to a crisis is reflected by owners and leads to dividend payout decisions under uncertainty.
Behavioral and institutional performance management theories are popular. Here is why we need to add a relational perspective
Authors: Kroll Alexander 
Published: July 2022

PurposeRecently, Modell (2022) and James et al. (2020) provided reviews of the performance management literature that subscribe to an institutional or behavioral perspective, respectively. This article draws attention to an alternative theoretical approach – the relational perspective.Design/methodology/approachThe article is based on a review of different literature.FindingsDecision-making in public organizations becomes more participatory or distributed, and service provision is increasingly collaborative. In line with these trends in public administration practice, performance management theory needs to be updated and principal-agent assumptions expanded. A relational perspective could provide such an update. This perspective emphasizes the group as the unit of analysis and the importance of collaborative routines to select, define, and use performance practices and metrics. The perspective also draws attention to the role of networks, social processes, and negotiations within teams, as well as group dynamics in decision-making.Originality/valueThe article outlines avenues for future relational research on performance management efforts, with the intention to encourage more empirical work in this area. The article also theorizes about promising connections between the relational, institutional, and behavioral perspectives, specifically linking a relational research agenda to propositions made by Modell (2022).
Impact of brand community supportive climates on consumer-to-consumer helping behavior
Authors: Liao Junyun , Wang Wei , Du Peng , Filieri Raffaele 
Published: July 2022

PurposeThis paper aims to explore whether or not and how brand community supportive climates (information- versus emotion-supportive climates) have an impact on consumer-to-consumer helping behavior.Design/methodology/approachA survey of users of cell phone brand communities was conducted, and data from 413 participants were used to validate the hypotheses of this study.FindingsResults indicated that emotion- and information-supportive climates enhance consumer-to-consumer helping behavior through consumer–community relationships (i.e. brand community identification and brand community commitment).Research limitations/implicationsTo enhance the external validity of this research, future studies could investigate other settings (e.g. social media-based brand communities and brands of other product types) in countries with different religious beliefs.Practical implicationsMarketers should create an environment where consumers feel informationally and emotionally supported within the brand community, thereby enabling the former to enhance their relationships with their brand communities and ultimately increase consumers' helping behavior.Originality/valueBy dividing the supportive climate into two parts, the current study enriched the literature on community climate. Moreover, the authors complemented and expanded the literature on consumer helping behavior.