bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cefepime-induced Neurotoxicity: A Retrospective Cohort Study in a
South-Indian Tertiary Healthcare Facility
Authors: Miraj Sonal Sekhar , Alijani Erfan , Kurian Shilia Jacob , Rao Mahadev , Saravu Kavitha 
Published: March 2022

Background:
Cefepime is a fourth-generation cephalosporin with a broad spectrum
coverage and anti-pseudomonal activity. The safety profile of cefepime was relatively favourable
until neurotoxicity was first reported in 1999. Despite cefepime-induced neurotoxicity (CIN), it
continues to be a principal part of parenteral treatment for various infections.

Objective:
The study aimed to determine the incidence and risk factors for CIN compared to other
antibiotics.

Methods:
A retrospective cohort study was conducted involving 738 patients over eight months in
Kasturba Medical College and Hospital, Manipal, India. Patients with cefepime were selected as
study cohort (SC; n= 496), and other antibiotics were included in the reference cohort (RC;
n=242).

Results:
The results showed that 53 (10.7%) patients developed neurotoxicity in the SC, whereas
12 (5%) patients in the RC. A significant association was found between neurotoxicity and
cefepime use (X2 =6.641; p=0.01). SC has a 2.29 times increased risk of neurotoxicity than RC
(OR: 2.29; 95% CI: 1.2-4.38). Risk estimation showed that renal failure patients had a 5.5 times
higher risk for CIN than non-renal failure patients (OR: 5.5; 95% CI: 2.98 - 10.17). CIN symptoms
were disorientation (38.5%), loss of consciousness (23.1%), drowsiness (18.5%), etc. The calculated
number needed to harm (NNH) for cefepime was 17.2.

Conclusions:
The study found a higher incidence of CIN compared to other antibiotics-induced
neurotoxicity and a harmful association between cefepime use and CIN development. Besides, renal
failure is a risk factor for CIN. Therefore, the study warrants the use of cefepime, where no
other alternatives are available.
Parameter Sensitivity Analysis of the Democratic Behavior of Swarm
Robots
Authors: Hanne Thomas , Hugli Andreas , Pereira Marco A. G. , Dornberger Rolf 
Published: March 2022

Aims:
The purpose of this studyis to determine under what conditions, such as noise and malfunction, successful consensus achievement in swarmrobotics is possible

Background:
Swarm robots can be used to solve exploration problems, such as the best-of-n problem.
Consensus achievement plays a crucial role as the swarm must collectively agree on a solution. This
task can be even more challenging considering noise and malfunctioning or rogue agents.

Objective:
This study aims to determine how robust the consensus achievement algorithm is against
noise and rogue agents, considering the effect of adding memory to the agents and further parameter
tuning.

Methods:
We implement a baseline based on the democratic honeybees algorithm and investigate the
performance and robustness of the consensus achievement during a number of computational
experiments. In particular, the number of agents in the swarm, the number of iterations, the number of
positions an agent can visit per iteration, the number of neighbors an agent shares its best option with,
and the majority threshold defining the majority based on a fraction of agents in the swarm, and the
minimum number of iterations to achieve consensus are investigated regarding their impact.

Results:
For better performance, memory has been implemented so that each agent remembers and
retains their previous highest quality score if no one better has been found in the current exploration
phase. We show that the algorithm is viable and offers robustness in the considered scenarios when
memory is added. In particular, we establish a baseline for the democratic honeybees algorithm and
ascertain adequate parameter values to ensure the algorithm's best performance. The algorithm is
sufficiently robust against noise, and to an extent, against rogue agents. Furthermore, parameter tuning
also proved to help the swarm explore very large search spaces

Conclusion:
The consensus algorithm appears sufficiently effective under adverse conditions such as
noise and rogue agents, especially when countermeasures are considered

Other:
Further scenarios such as specific communication topologies could be investigated in future
research.
Comparing SF-36 Scores Collected Through Web-Based Questionnaire Self-completions and Telephone Interviews: An Ancillary Study of the SENTIPAT Multicenter Randomized Controlled Trial
Authors: Açma Ayşe , Carrat Fabrice , Hejblum Gilles 
Published: March 2022

Background
The 36-Item Short Form Health Survey (SF-36) is a popular questionnaire for measuring the self-perception of quality of life in a given population of interest. Processing the answers of a participant comprises the calculation of 10 scores corresponding to 8 scales measuring several aspects of perceived health and 2 summary components (physical and mental). Surprisingly, no study has compared score values issued from a telephone interview versus those from an internet-based questionnaire self-completion.

Objective
This study aims to compare the SF-36 score values issued from a telephone interview versus those from an internet-based questionnaire self-completion.

Methods
Patients with an internet connection and returning home after hospital discharge were enrolled in the SENTIPAT multicenter randomized trial on the day of discharge. They were randomized to either self-completing a set of questionnaires using a dedicated website (internet group) or providing answers to the same questionnaires administered during a telephone interview (telephone group). This ancillary study of the trial compared SF-36 data related to the posthospitalization period in these 2 groups. To anticipate the potential unbalanced characteristics of the responders in the 2 groups, the impact of the mode of administration of the questionnaire on score differences was investigated using a matched sample of individuals originating from the internet and telephone groups (1:1 ratio), in which the matching procedure was based on a propensity score approach. SF-36 scores observed in the internet and telephone groups were compared using the Wilcoxon-Mann-Whitney test, and the score differences between the 2 groups were also examined according to Cohen effect size.

Results
Overall, 29.2% (245/840) and 75% (630/840) of SF-36 questionnaires were completed in the internet and telephone groups, respectively (P<.001). Globally, the score differences between groups before matching were similar to those observed in the matched sample. Mean scores observed in the telephone group were all above the corresponding values observed in the internet group. After matching, score differences in 6 out of the 8 SF-36 scales were statistically significant, with a mean difference greater than 5 for 4 scales and an associated mild effect size ranging from 0.22 to 0.29, and with a mean difference near this threshold for 2 other scales (4.57 and 4.56) and a low corresponding effect size (0.18 and 0.16, respectively).

Conclusions
The telephone mode of administration of SF-36 involved an interviewer effect, increasing SF-36 scores. Questionnaire self-completion via the internet should be preferred, and surveys combining various administration methods should be avoided.

Trial Registration
ClinicalTrials.gov NCT01769261; https://www.clinicaltrials.gov/ct2/show/record/NCT01769261
TAILORING OF SOLUBILITY OF IBUPROFEN IN THE PRESENCE OF HYDROPHILIC EXCIPIENTS IN WATER-ETHANOL MIXTURES BY CRYSTALLIZATION METHOD
Authors: AFROSE AFRINA , T. WHITE EDWARD , RASHID MD ABDUR , HOWES TONY , ALHAMHOOM YAHYA 
Published: March 2022

Objective: The objective of this study was to determine the effect of some commonly used pharmaceutical excipients on the solubility of Ibuprofen (Ibu) in a co-solvent consisting of water (W) and ethanol (E).
Methods: The Ibu solubility studies were carried out by dissolving the drug to equilibrium into aqueous ethanol solvents at a fixed temperature. The temperature of the water bath was kept constant (±0.1 °C of the desired temperatures 10, 25 and 40 °C). The solubility of Ibu was measured by using UV spectrophotometry.
Results: The low solubility (~ 50 ppm) of Ibu without excipients in water (zero ethanol) was observed. However, Ibu solubility was increased near exponentially with excipient containing co-solvent system. The maximum solubility of Ibu (1726 ppm) was occurred in a co-solvent containing 1.52% leucine, 5.22% mannitol, 0.25% HPMC, 1.55% Pl F127 and 10.75% w/w ethanol. The phase separation between 34% and 63% w/w E/(E+W) was observed at 40 °C. The individual effect of Pl F127 on enhancing the Ibu solubility was significant.
Conclusion: The individual addition of leucine, mannitol and HPMC has limited impact on the solubility of Ibu. However, the effect of combining these excipients together on Ibu solubility is significantly high.
METODE DAKWAH PENCERAMAH DI KOMUNITAS â€œYUK NGAJIâ€ SOLO
Authors: Aula Latif Ghufron , Abas Zainul 
Published: March 2022

The existence of technological developments,Â in the end,Â makes all information easily accessible. Likewise with the youth lifestyle, one of which is in the city of Surakarta, whether it refers to the proper use of technology according to the times, or vice versa, falling into a wrong path. This is a challenge for the â€œYuk Ngajiâ€ community to direct youthÂ towards positive and beneficial things. This study aims to describe the daâ€™wah method by preachersÂ in the â€œYuk Ngajiâ€ Community to encourage youth hijrahÂ in Surakarta. The method used in this study was a qualitative descriptive method by describing phenomena in the field through data collection and Instagram social media. The data collection technique was carried out through observations, interviews, and documentation. This study foundÂ that the daâ€™wah method by preachers in "Yuk Ngaji" Community to encourage youth hijrahÂ in Surakarta was byÂ usingÂ bill hikmah and mauidhah hasanah. The da'wah method carried out by the preachersÂ using the bil hikmah method was carried out by identifying the conditions of the da'wah target, making the study interesting and making comfortable for youthÂ congregations to follow. Furthermore, the mauidhah hasanahÂ daâ€™wah method was carried out through preachersÂ who deliver the material subtly so that it can move the hearts of the youthÂ to be able to practice it in everyday life.
NEWSCASTING: KONSEP DAN PERKEMBANGANNYA DI ERA 4.0
Authors: Restendy Mochammad Sinung , Munawaroh Eka , Daud Bagastitan , Perdana Rizki Okta , Wihandani Mahera Army , Istanti Sintia 
Published: March 2022

NewscastingÂ merupakan aktivitas seorang newscaster/penyiar berita. Fungsi dan tujuan utama dari kegiatan newscastingÂ adalah penyampaian sebuah informasi berupa berita kepada audiens. Dalam kegiatan newscasting, seorang newscasterÂ harus menguasai teknik-teknik dalam menyampaikan berita, tujuannya agar informasi yang ingin disampaikan dapat diterima dengan baik oleh audiens. Teknik-teknik yang harus diperhatikanÂ adalahÂ intonasi, artikulasi, volume dan tekanan suara. Seiring dengan perkembangan teknologi, kegiatan newscastingÂ menjadi lebih efektif dan efisien. Kegiatan newscastingÂ dapat memanfaatkan alat dan juga platform-platformÂ baru yang bermunculan. Tetapi, banyaknya platformÂ yang bermunculan dan kemajuan alat dan teknologi yang ada, tidak serta merta membuat newscastingÂ di era ini menjadi lebih mudah. Salah satu masalah yang dihadapi di Indonesia untuk proses digitalisasi siaran termasuk kegiatan newscastingÂ adalah masalah pemerataan pembangunan teknologi di Indonesia.
Pengaruh Komitmen Birokrasi dan Total Quality Management Terhadap Kualitas Pelayanan Ijin Usaha Industri (Suatu Usaha Meningkatkan Investor di Medan Sumatra Utara)
Authors: Revida Erika 
Published: March 2022

The fundamental problems in this research were the less of quality of industrial permit services: inefficient,Â ineffective, irresponsive, and unfair. The cost of services were expensive, inappropriate with standard andÂ also length bureaucracy enchain which must pass by, so that require bureaucracy commitment and TotalÂ Quality Management. The purposes of this research were to study and analyse the influence of BureaucracyÂ Commitment Towards Total Quality Management, Bureaucracy Commitment Towards Quality of IndustrialÂ Permit Â Service, Â Total Â Quality Â Management Â Towards Â Quality Â of Industrial Â Permit Â Service, Â BureaucracyÂ Commitment and Total Quality Management jointly Towards Towards quality of Industrial Permit Service inÂ Medan North Sumatera. Research method which is used in this research is survey. Sampling technique isÂ proportional random sampling. Technique of data analyse used is path analysis. Before using path analysis,Â data must be change into interval scale by Method of successive interval. Test of validity instrument usedÂ by Â correlation Â of Â Pearson Â and Â test Â of Â reliability Â used Â by Coefficient Â of Â Cronbach. Â Data Â are Â used Â in Â thisÂ research are quantitative and qualitative. The Results of this research show that Bureaucracy CommitmentÂ has positive influence on Total Quality Management, Bureaucracy Commitment has positive influence onÂ Quality of Industrial Permit Service, Total Quality Management has positive influence on Quality of IndustrialÂ Permit Service, Bureaucracy Commitment and Total Quality Management jointly have positive influence onÂ Quality of Industrial Permit Service in Medan North Sumatera.
Cooperativas de Trabajo y la Dificultad de Alcanzar la Autogestión Horizontal
Authors: Henry Maria Laura , Neffa Julio Cesar 
Published: March 2022

Este artículo se propone examinar el surgimiento de una fábrica recuperada por sus trabajadores, cómo se convirtió en una cooperativa de trabajo y su modo de funcionamiento actual, con el objetivo de identificar los alcances y límites de la autogestión.
El caso en estudio es una cooperativa productora de papel, ubicada en la ciudad de La Plata en Argentina. En medio de la crisis económica de 2001, la empresa quebró y los trabajadores la ocuparon para no perder sus puestos de trabajo y continuar con la producción. De esta manera, se convirtió en una empresa bajo la propiedad de sus trabajadores que comenzó a funcionar como una cooperativa.
Los resultados presentados se basan en datos recopilados con diferentes técnicas: entrevistas en profundidad, observación participante, revisión documental (reportajes, artículos de prensa, videos, etc.) y una encuesta aplicada a toda la población de trabajadores de la cooperativa. Los datos recolectados nos permitieron conocer la historia de la cooperativa, analizar los cambios en el proceso laboral y, especialmente, identificar la división social y técnica del trabajo, así como las relaciones laborales existentes.
En la parte central de nuestro artículo desarrollamos una serie de aspectos que consideramos que han sido un obstáculo para que en la cooperativa pudiese desplegarse todo el potencial de la autogestión. Al respecto, examinamos primero en qué sentido la autogestión emergió como una estrategia de tipo defensiva para conservar los puestos de trabajo y no fue un fin en sí mismo. En segundo término, mostramos por qué en la cooperativa bajo análisis hubo una difusión limitada de los principios de la autogestión y del cooperativismo. Esto impidió que surgiese una nueva cultura laboral, relaciones de trabajo basadas en la colaboración y la confianza, y una nueva visión sobre el proceso productivo en la cual todos los trabajadores se sintieran comprometidos en participar activamente en la toma de decisiones. En tercer lugar, describimos la existencia de una fragmentación al interior del colectivo de trabajadores, basada en la distancia generacional y en valores sobre el trabajo diferenciales, lo cual ha obstaculizado la consolidación de un colectivo de trabajadores comprometido con objetivos (productivos y sociales) compartidos. Por último, explicamos en qué sentido los determinantes técnicos y tecnológicos, así como el entorno económico más amplio han limitado la expansión de la autogestión en la fábrica bajo estudio.
Evaluation of the accuracy of three-dimensionally printed patient-specific guides for transsphenoidal hypophysectomy in small-breed dogs
Authors: Roh Yoonho , Kim Daehyun , Jeong Seongmok , Lee Haebeom 
Published: March 2022

Abstract

OBJECTIVE
To assess the accuracy of transsphenoidal hypophysectomy using 3-D printed patient-specific guides (3D-PSGs) in small-breed dogs.

ANIMALS
Heads obtained from the cadavers of 19 small-breed dogs (ex vivo portion of study) and 3 healthy adult (3 to 4 years) purpose-bred Beagles with a median body weight of 9.2 kg.

PROCEDURES
In the ex vivo study, CT images of the cadavers were collected. The position, width, and length of the pituitary fossa and the pilot hole (insertion angle and place) were measured. Using PSGs, 19 pilot holes were made for the pituitary gland fossa, and CT was performed to assess the position accuracy. In the in vivo study, 3 surgical windows from the pilot holes were made using PSGs. Repeated CT and MRI were performed to evaluate the safeness and effectiveness of PSGs, followed by necropsy.

RESULTS
In the ex vivo study, the median (interquartile range) difference between the pre- and postoperative insertion angles was 2° (0° to 3.5°) and the median deviation of the pilot hole was 0.46 mm (0 to 1.58 mm). In the in vivo study, the surrounding structures were not damaged, and favorable outcomes were evident in terms of the shape, size, and position of the surgical window.

CLINICAL RELEVANCE
3D-PSGs provided a safe and effective surgical window for transsphenoidal hypophysectomy. Our findings emphasized the applicability of PSGs in brain surgery, in terms of accuracy and effectiveness.
Hubungan Antara Self Control Dengan Nomophobia pada Mahasiswi Fakultas Psikologi Universitas Kristen Satya Wacana
Authors: Sapulete Citra Wira , Ambarwati Krismi Diah 
Published: March 2022

Penelitian ini merupakan penelitian kuantitatif dengan jenis penelitian korelasional. Tujuan dari penelitian adalah untuk melihat hubungan antara self control dengan nomophobia pada mahasisiwi Fakultas Psikologi Universitas Kristen Satya Wacana. Adapun hipotesis penelitian yang diajukan dalam penelitian ini, yakni ada hubungan yang negatif dan signifikan antara self control dengan nomophobia pada mahasiswi Universitas Kristen Satya Wacana. Total partisipan dalam penelitian ini sebanyak 213 mahasisiwi dengan menggunakan teknik sampling purposive. Pengumpulan data dilakukan dengan cara penyebaran kuesioner secara online melalui google form. Terdapat dua alat ukur yang digunakan dalam penelitian ini, yaitu Self Control Scale (SCS) yang dibuat oleh Tangney, Baumeister Boone (2004) dengan skor reliabilitas sebesar 0,839. Selain itu ada Nomophobia Questionnaire (NMP-Q) yang dibuat oleh Yildirim (2014) dengan skor reliabilitas sebesar 0,924. Hasil yang diperoleh dari penelitian ini adalah terdapat hubungan negatif dan signifikan antara self control dan nomophobia (rxy= -0,372; 0,00 p0,05). Dengan demikian, bahwa hipotesis dalam penelitian ini diterima..
Psychology of Breastfeeding: From Self Narration to Digital Technology
Authors: Murty Ade Iva , Anjani Safira Binar 
Published: March 2022

Background: Breastfeeding has been a very precious source for the development of infants and children. Generally, most of the studies about breastfeeding come from a medical knowledge point of view. However, the process of sustaining exclusive breastfeeding is not an easy task for a mother. As breastfeeding involves a mother's decision-making process, the study explores how mothers live in a megapolitan area, preserving exclusive breastfeeding until baby 6 months old and partially continued up to 2 years old. Psychology emphasizes individual (psychological) and macro factors which have a significant role in enabling exclusive breastfeeding. Methodology: The study methodology was qualitative with case study type. Methods of data collection were an in-depth interview and on-the-spot interview observation. We have interviewed 4 participants. All of them are urban mothers (women live in megapolitan areas of Jakarta Greater Area or JABODETABEK). Age ranges from 20 to 40 years old, with at least an experience of exclusive breastfeeding and the child’s age currently not more than 12 years old. 2 out of 4 participants are working mothers, who have to strive every day between domestic and work domain.Result: All 4 research subjects are typically kind of “pejuang ASI” (breastfeeding warrior), a term used for representing a maternal woman who fights hard to breastfeed, as the best nutrition for a baby. It was shown that psychological processes of preserving exclusive breastfeeding of an urban mother significantly reflect the role of self-narration around the perception of breastfeeding as part of “natural mother” schema and how digital technology helps a mother to get more support and solve breastfeeding and baby’s problems.Conclusion: First Mother’s schema about breastfeeding and attachment to the baby are important to motivate her to maintain exclusive breastfeeding. we need to know how her schema about breastfeeding and her attachment to the baby. Second, it is important to identify her skills and knowledge on using digital technology diligently, for a more productive and comfortable process of delivering the best nutrition for the baby.
MOTIVASI KEPEMIMPINAN DALAM LEMBAGA PENDIDIKAN
Authors: Mubiarto Akhli Nur , Syarifuddin Syarifuddin 
Published: March 2022

Abstrak: Motivasi dalam lembaga pendidikan sangat penting, karena setiap personil atau anggota pegawai pasti memerlukan suatu motivasi, baik dari dalam diri pribadi maupun dari orang lain, untuk itu apabila seseorang sudah terdorong atau termotivasi maka kinerja seseorang itu akan meningkat sehingga dapat mencapai sebuah tujuan. Motivasi diperlukan karena dengan motivasi ini diharapkan setiap orang dapat bekerja keras dan bersemangat untuk mencapai produktivitas kerja yang tinggi. Tujuan dalam kajian ini untuk mengetahui motivasi kepemimpinan dalam lembaga pendidikan serta hubungan antar kepemimpinan terhadap lembaga pendidikan. Penelitian ini menggunakan metode deskritif kualitatif dengan pendekatan studi pustaka dengan mengumpumpulkan berbagai referensi. Secara umum kepemimpinan dapat dipahami sebagai pemimpin yang mampu mengarahkan, membina atau mengatur, menuntun dan juga menunjukkan ataupun mempengaruhi. Serta lembaga pendidikan adalah suatu wadah yang berguna untuk membina manusia, membawa kearah masa depan yang lebih baik. Kepemimpinan dalam lembaga pendidikan dapat disebut sebagai seseorang yang memegang otoritas yang menentukan perkembangan lembaga pendidikan. Sebagai pemimpin pendidikan yang profesional seorang pemimpin dituntut mampu melakukan perubahan yang bersifat pengembangan dan penyempurnaan.Kata Kunci: Motivasi, Kepemimpinan, dan Lembaga Pendidikan Abstract: Motivation in educational institutions is very important, because every personnel or employee member definitely needs a motivation, both from within himself and from others, for that if someone is already motivated or motivated, that person's performance will increase so that he can achieve a goal. Motivation is needed because with this motivation it is expected that everyone can work hard and be enthusiastic to achieve high work productivity. The purpose of this study is to determine the motivation of leadership in educational institutions and the relationship between leadership and educational institutions. This study uses a qualitative descriptive method with a literature study approach by collecting various references. In general, leadership can be understood as a leader who is able to direct, foster or regulate, guide and also show or influence. And educational institutions are a useful forum for fostering human beings, leading to a better future. Leadership in educational institutions can be referred to as someone who holds the authority that determines the development of educational institutions. As a professional educational leader, a leader is required to be able to make changes that are developmental and perfect.Keywords: Motivation, Leadership, and Educational Institutions