bluuebunny/crossref_metadata_2025_split huggingface dataset:
A scalable and real-time system for disease prediction using big data processing
Authors: ED-DAOUDY Abderrahmane , Maalmi Khalil , ouaazizi Aziza El 
Published: April 2022

Abstract
The growing chronic diseases patients and the centralization of medical resources cause significant economic impact resulting in hospital visits, hospital readmission, and other healthcare costs. This paper proposes a scalable, big data, real-time health status prediction and analytical system to filter, manage, process, predict and store streaming health data. The proposed system uses Twitter as data source, Apache Kafka as ingestion tool, Apache Spark as computing engine, Apache Cassandra as storage engine and Apache Zeppelin as analytical tool. Proposed Spark Parallel Random Forest (SPRF) is used as data classifier. The idea is to use Twitter as a communication channel to transmit data generated by IoT medical devices to a system to perform analytics in a real-time fashion, using streaming. Thus, Twitter users tweet attributes related to health, Kafka streaming receives all desired tweets attributes and ingest them to Spark streaming. Here, a machine learning algorithm model is applied to predict health status and send back a response message through Kafka. The result will be saved into distributed database for historical data analysis and visualization. The system has been tested with a Heart disease dataset from UCI. RF classification performances are compared to other machine learning classifiers of Apache Spark MLlib library. To test the system scalability, a comparative study between execution time of RF on Spark environment and on WEKA for both training and application stages. The results show significant better performances of Spark cluster in terms of scalability and computing times.
The association between iron deficiency anemia at infancy and attention deficit hyperactivity disorder
Authors: Yackobovitch-Gavan Michal , Ben-Hefer Daniel , Meyerovitch Joseph 
Published: April 2022

Abstract
Purpose: To examine the association between iron deficiency anemia (IDA) at age 9-18 months and attention deficit/ hyperactivity disorder (ADHD) during childhood.Methods: This case-control study included all the children insured by Clalit Health Services, aged 9-18 months between June 1, 2004 and December 30, 2013 (aged 6-18 years at data collection) with documented hemoglobin (Hb) and mean cell volume levels (MCV). The analysis comprised 19,467 children diagnosed with ADHD based on medical documentation of at least two consecutive stimulant prescriptions. The control group comprised 39,004 children without a record of receiving any prescriptions for ADHD. IDA was defined as Hb<10.5gr/dl and 60fl<MCV<75fl. Moderate anemia was defined as Hb<10gr/dl. The prevalence of IDA was compared by Pearson Chi-Square test and by logistic regression, adjusted to age, sex, cultural background and socioeconomic status.Results: IDA prevalence was 0.6% lower in the ADHD than the control group: n=667 (3.4%) vs. n=1,541 (4.0%) (P=0.002), adjusted OR=0.863 (95%CI: 0.816–0.910). The prevalence of moderate ID anemia (Hb<10gr/dl) was similar in the ADHD and the control groups (0.9% vs. 1.0%, P=0.149) (adjusted OR=0.877; 95%CI: 0.725–1.047). Hb at age 9-18 months was clinically similar in the ADHD and control groups (11.965±0.880 and 11.921±0.889 gr/dl, respectively); however, this difference was statistically significant (P<0.001), apparently due to the large sample size. Conclusions: IDA in infants 9-18 months old was not found to be associated with an increased risk of ADHD during childhood. Other etiological factors for ADHD, such as genetics and environmental factors should be further studied.
Spectrum-effect relationship between GC-MS fingerprints and antidepressant-like effect of Schisandra chinensis (Turcz.) Baill. essential oil
Authors: Tan Liang , Yang Yunfang , Peng Jing , Zhang Yue , Wu Bo , He Bosai , Jia Ying , Yan Tingxu 
Published: April 2022

Abstract
The present study aimed to evaluate the antidepressant-like effect of essential oils from Schisandra chinensis (Turcz.) Baill. (SEO) and its possible mechanisms of SEO. Behavioral despair mouse model in vivo and H2O2-induced PC12 cells model in vitro were employed. And the potential effective components were identified by the spectrum-effect relationships analysis. SEO significantly decreased the immobility time in the forced swimming test and tail suspension test, which indicated a promising antidepressant-like effect of SEO in depressed mice. The decreased levels of SOD, GSH, and CAT, and increased levels of MDA were significantly reversed by SEO treatment, which showed good antioxidant activities both in vitro and in vivo. Besides, SEO significantly promoted the nuclear translocation of Nrf2 and the expression of HO-1 in depressed mice and H2O2-induced PC12 cells. The histopathological examination results showed a potential neuronal protective effect of SEO in the hippocampus and cortex. Furthermore, the upregulation of PI3K/AKT/GSK3β signaling was observed after SEO treatment. Additionally, based on the spectrum-effect relationship analysis, 9 peaks were identified positively correlated with the antioxidant activity of SEO. These results suggested that SEO upregulated the PI3K/AKT/GSK3β signaling, and then promoted Nrf2/HO-1 pathway to improve the oxidative stress status and exerted the antidepressant-like effects.
Multinomial classification to predict the most effective adjuvant combination therapies for breast cancer patients
Authors: ERTEL Merouane , AMALI Said , Faddouli Nour-eddine El 
Published: April 2022

Abstract
Accurately predicting effective treatment methods based on personalized tumor genetic profiles is a major goal of precision cancer medicine. Because people with breast cancer at comparable stages respond differently to treatment, it is essential to gain insight into the variables that influence treatment success. This study presents a supervised multinomial logistic regression model for predicting the best adjuvant therapy for breast cancer patients to lower the probability of metastatic recurrence. This model will assist health professionals (physicians) in making judgments about which medicinal regimens to suggest to patients. In addition, this article presents a comparison of several multinomial machine learning methods (Logistic Regression (LR), Naive Bayes (NB), Random Forest (RF), Decision Tree (DT), Support Vector Machine (SVM), and Neural Network (ANN)). The results reveal that the Random Forest classifier is more effective in terms of adjuvant therapy combination prediction accuracy.
Long term effects of crop rotation and fertilization on crop yield stability in southeast China
Authors: Zhang Licheng , Yuan Jie , Zhang Mingqing , Zhang Yongchun , Wang Liming , LI Juan 
Published: April 2022

Abstract
The objective of this study was to determine the effects of different fertilization programs and crop rotations on crop yield stability. A 9 y field experiment was conducted from 2013 to 2021 to evaluate the effects of combinations of two annual crop rotations and two methods of applying fertilizer on crop yield stability. Crop rotations were kidney bean–mustard–rice (P-B-O) and kidney bean–mustard–cowpea (P-B-V) each year. Fertilization methods were recommended fertilization (RF) and conventional fertilization (CF). The indexes Wi2 (Wricke ecovalance), coefficient of variation (CV), and sustainable yield index (SYI) were used to quantify the long term effects of crop rotation and fertilization on crop yield stability, and a yield change trend model was used to predict future production. For fertilization program RF, average kidney bean and mustard yields in rotation P-B-O increased respectively by 7.47% and 19.37% over P-B-V in the 9 years of the project. For CF, average kidney bean and mustard yields for P-B-O increased respectively by 14.99% and 18.33% over P-B-V. Wi2 indexes of kidney bean and mustard for P-B-O (respectively 116 and 956) were significantly less than for P-B-V (respectively 147.87 and 1259.67). SYI for kidney beans and mustard in P-B-O (respectively 0.63 and 0.57) were significantly greater than for P-B-V (respectively 0.50 and 0.42). The trends of crop average yields for RF and CF show that the average yield trends of kidney bean in P-B-O (respectively 32.41 and 32.34) were greater than in P-B-V (respectively 29.56 and 27.45). The trends of average yields of mustard for RF and CF in P-B-O (respectively 64.18 and 60.87) were greater than in P-B-V ( respectively 51.74 and 51.87). The preceding results led to the conclusion that long term annual P-B-O rotation combined with RF has a considerable advantage in increasing yield and maintaining yield stability, thus establishing the sustainability of this crop system.
Comprehensive characterization of flavonoid derivatives in young leaves of core-collected soybean (Glycine max L.) cultivars based on high-resolution mass spectrometry
Authors: Lee Suji , Kim Heon-Woong , Lee So-Jeong , Kwon Ryeong Ha , Na Hyemin , Kim Ju Hyung , Choi Yu-Mi , Yoon Hyemyeong , Kim Yong-Suk , Wee Chi-Do , Yoo Seon Mi , Lee Sang Hoon 
Published: April 2022

Abstract
Most previous studies have been focused on isoflavone profile with biological activities from soybean seed and its related products. However, in the present study, eighty-three flavonoid derivatives (55 flavonols, 9 flavones and 19 isoflavones) were comprehensively identified and quantified from young leaves of 21 core-collected soybean cultivars based on ultra-performance liquid chromatography-diode array detector with quadrupole time of flight/mass spectrometry (UPLC-DAD-QToF/MS). Among total content (342.5-992.7 mg/100 g, dry weight) of 83 derivatives found in these soybean leaves (SLs), the abundant flavonols (83.6%, 275.1–854.0) were primarily composed of 26 di- and 23 tri- glycosides combined to the aglycones (K, kaempferol; Q, quercetin; I, isorhamnetin), and distributed in the order of K, Q and I. Particularly, K-rich SLs (yellow coated seed), Nongrim 51 (breeding line) and YJ208-1 (landrace) contained mainly kaempferol 3-O-(2"-O-glucosyl-6"-O-rhamnosyl)galactoside and 3-O-(2",6"-di-O-rhamnosyl)galactoside, and were expected to be superior cultivars by their higher flavonoids. Besides, the new tri-I-glycosides (soyanins Ⅰ~Ⅴ) were presented as predominant components in Junyeorikong (landrace, black). Thus, these detailed profiles will support breeding of superior varieties with excellent biological activities as well as relationship with seed anthocyanins production, and suggest that the SLs can be considered as a valuable edible resource due to their rich flavonoids.
How Experienced Wound Care Nurses Conceptualize What to Do in Pressure Injury Management
Authors: Lee Ye-Na , Chang Sung Ok 
Published: April 2022

Abstract
Background: Conceptual understanding of the perceptions that wound care nurses use to determine how to manage pressure injuries (PI) may provide information for improving their PI care competency. The aim of this study is to explore and describe the way wound care nurses experience and perceive PI management. Methods: A qualitative, phenomenographic approach was used in this study. Semi-structured interviews were used for data collection with twenty wound care nurses. The eight steps of qualitative data analysis for a phenomenographic study were employed to develop an understanding of participants’ experience of pressure injury management.Results: The analysis resulted in an assessment domain and an intervention domain, each containing three descriptive categories based on five identified conceptions. The categories were as follows: ”comparison”, “consideration”, and “monitoring” in assessment, and “creation”, “conversation” and “judgement” in intervention.Conclusions: This study has created a framework for understanding PI management based on practical knowledge. These findings could potentially be applied to improve nurse PI care competency and patient safety.
An Improved Algorithm Based on Game Theory to Detecting Overlapping Community
Authors: Mei WanTing , Zhang Sheng , Liu Rui 
Published: April 2022

Abstract
Aiming at the problem that the community discovery algorithms based on game theory have the disadvantage of node update strategy sequence and the complexity of node strategy space, an improved algorithm for overlapping community discovery based on game theory is proposed, which regards the formation of communities as the game of nodes in the network. First, get the initial community of the node through a label propagation algorithm, and get the set of bridge nodes; then, sort these nodes from large to small according to the aggregation of the nodes, choose to join the community, convert the community, and leave the community strategy to improve own profit; when all nodes participating in the game cannot increase their profit by changing strategies, the algorithm ends; finally, experiments and analysis on artificially generated networks and real-world networks have proved the feasibility of the algorithm, and it is comparable to other similar compared with the algorithm, the algorithm proposed in this paper effectively reduces the running time and improves the accuracy.
Effects of postoperative delirium on parents’ illness uncertainty and quality of life in children after ventricular septal defect repair
Authors: Huang Jiang-shan , Chen Yu-kun , lin Shi-hao , Lin Wen-hao , Chen Qiang , Zheng Yi-Rong 
Published: April 2022

Abstract
Objective
The purpose of this study was to investigate the illness uncertainty and quality of life of parents of children with postoperative delirium.
Methods
178 patients were enrolled and assigned to POD (n = 77) and no-POD (n = 101) based on evaluation of delirium. Delirium was assessed by a CPAD. Chinese version of the Parents' Perception of Uncertainty Scale (PPUS) was used to evaluate the Parents' illness uncertainty. Quality of life was assessed with the SF-36 scale at discharge and third postoperation months.
Results
In terms of clinical data, there were no significant differences in gender and size of ventricular septal defect between the two groups, but significant differences in age, operation time, CPB time, mechanical ventilation time and ICU time between the two groups. In terms of the illness uncertainty scores, there are statistically significant differences between the two groups on ambiguity, lack of clarity, lack of information and unpredictability. In terms of the parents' quality of life, at discharge, there were no significant differences in PH, SF, RP, BP, and GH between the POD group and the no-POD group. There was no statistical significance in PH, SF, RP, BP, GH and RE at third postoperation months. In terms of the relationship between Parents' illness uncertainty and quality of life, there was a negative correlation between illness uncertainty and quality of life in POD and no-POD group.
Conclusion
Parents of children with delirium after ventricular septal defect repair had significantly higher levels of illness uncertainty than parents of children without delirium. Moreover, the higher the illness uncertainty, the worse the quality of life.
Clinical and sociodemographic determinants of disease-specific health-related quality of life in long-term breast cancer survivors
Authors: Doege Daniela , Thong Melissa S.Y. , Koch-Gallenkamp Lena , Bertram Heike , Eberle Andrea , Holleczek Bernd , Nennecke Alice , Pritzkuleit Ron , Waldmann Annika , Zeissig Sylke R. , Brenner Hermann , Arndt Volker 
Published: April 2022

Abstract
Purpose: It is important to monitor disease-specific health-related quality of life (HRQoL) in breast cancer (BC) survivors to identify potential unmet supportive care needs. However, previous studies were characterized by small samples of mostly short-term survivors and were limited to certain age ranges, stages and/or treatments.Methods: We used data from 3045 long-term BC survivors (5-15 years post-diagnosis) recruited in a German multi-regional population-based study. We assessed disease-specific HRQoL with the EORTC QLQ-BR23, scoring from 0-100. Differences in functioning and symptoms according to age at survey, self-reported treatments, stage, and disease status (disease-free vs. active disease) were assessed with multiple regression. Active disease was defined as any self-report of recurrence, metastasis or second primary cancer after the index cancer.Results: Older BC survivors reported a higher body image and a better future perspective, but lower sexual functioning. Survivors aged 30-49 years who had breast-conserving therapy or mastectomy with breast reconstruction reported a better body image compared to those who had mastectomy only. We also found differences in symptoms according to treatments in some age groups. Stage at diagnosis was not associated with HRQoL overall and in most age subgroups. Disease-free BC survivors aged 30-79 years reported a better future perspective and less systemic therapy side effects than those with active disease.Conclusion: Several treatment-associated symptoms and functioning detriments were found 5-15 years after diagnosis. The results emphasize the need of a comprehensive, individualized survivorship care, recognizing differential needs of long-term BC survivors according to age, treatment modalities, and disease status.
Impacts of shrub encroachment on soil quality in the native Monte rangelands of Southwestern Buenos Aires, Argentina
Authors: Ambrosino Mariela Lis , Torres Yanina , Lucero Cinthia Tamara , Lorda Graciela Susana , Ithurrart Leticia Soledad , Martínez Juan Manuel , Armando Lorena Vanesa , Garayalde Antonio , Busso Carlos Alberto 
Published: April 2022

Abstract
Purpose
Shrub encroachment has been associated with changes in the spatio-temporal distribution of soil nutrient and vegetation. We determined the effect of shrub cover on chemical and biochemical indicators of soil quality (SQ) in a semiarid Monte rangeland of Argentina.
Methods
In spring 2017 and 2018, 6 paddocks were selected and 10 m transects were placed in an area with (Sh) and without shrubs (WSh). Within each transect, composite soil samples (0–10 cm depth; n = 6) were taken from sites with bare ground-litter (BL), grass (G) and shrub (S) cover. Soil samples were analyzed to determine chemical and biochemical parameters associated with the efficient use of water, nutrients, functionality and activity of microbial communities.
Results
When these indicators were evaluated individually, Sh-G and Sh-S sites presented high values of soil organic matter (SOM), soil organic nitrogen (SON), particulate organic matter (POM) and cellulase activity (CA); the shrub effect was not consistent for the other parameters related to nitrogen and phosphorus cycle. In multivariate analysis, values of POM, SON, CA and anaerobic nitrogen were positively correlated between them in both years; Sh-G and WSh-G sites were associated with different SQ parameters, and BL soils of Sh and WSh transects behaved similarly.
Conclusions
We demonstrated that shrubs do not have a negative effect on SQ. Moreover, in the context of appropriate grazing management and moderate shrub cover presence of woody species has a beneficial effect on POM, SON and CA with direct impacts on organic matter decomposition, nutrient availability and microbial activity.
Prognostic value of functional SMAD4 localization in extrahepatic bile duct cancer
Authors: Takayama Hirotoshi , Kobayashi Shogo , Gotoh Kunihito , Sasaki Kazuki , Iwagami Yoshifumi , Yamada Daisaku , Tomimaru Yoshito , Akita Hirofumi , Asaoka Tadafumi , Noda Takehiro , Wada Hiroshi , Takahashi Hidenori , Tanemura Masahiro , Doki Yuichiro , Eguchi Hidetoshi 
Published: April 2022

Abstract
Background. SMAD4 is a key mediator of TGFβ signaling and one of the mutated genes in extrahepatic bile duct cancer (eBDC). SMAD4 has dual functions, in carcinogenesis via silencing and in tumor invasion/metastasis via signaling, depending on tumor stage. We investigated the localization of functional SMAD4 (e.g., invasion or metastasis) and its association with chemo-radiation therapy. Methods. We performed SMAD4 immunostaining on 98 resected eBDC specimens and evaluated the presence of the functional form of nuclear SMAD4 at the central lesion, invasion front, and metastatic lymph node. We also examined the influence on chemotherapy after recurrence (n=33) and neoadjuvant chemo-radiation therapy (NAC-RT, n=21) and the prognostic value of using retrospective data. Results. In 73 patients without NAC-RT, 8.2% had loss of SMAD4 expression and 23.3% had heterogeneous expression. Patients without SMAD4 expression at any site had significantly poorer overall survival (OS) than other patients (P=0.014). Expression of SMAD4 at the invasion front was related to survival (recurrence-free survival [RFS] P=0.033; OS P=0.047), and no SMAD4 expression at the metastatic lymph node was related to poorer OS (P=0.011). The patients who had high SMAD4 expression had poorer prognosis after recurrence (RFS P=0.011; OS P=0.056). At the residual cancer in the resected specimen, SMAD4 was highly expressed after NAC-RT (P=0.039). Conclusions. Loss of SMAD4 protein expression was a poor prognostic factor in resectable eBDC. However, the intensity of functional SMAD4 in eBDC is a marker of resistance to chemotherapy and malignant potential at advanced stages.
How to reduce fear, risk, and uncertainty in scientific knowledge? Risk communication of endocrine-disrupting chemicals: surveying the general public perceptions and knowledge
Authors: Lee Yong Jin , Lim Young Wook 
Published: April 2022

Abstract
Endocrine-disrupting chemicals (EDCs) pose a threat to both human health and environment. Since the exact definitions and management systems of EDCs differ between countries and organizations, it is necessary to establish a system for evaluating the basic information and disseminating it appropriately. This study aimed to assess the risk communication of EDCs among the Korean public through a nationwide survey of their perceptions and general knowledge regarding the topic.The survey was conducted on 2000 Korean individuals, including vulnerable populations. The questionnaire included questions on quality of life, general awareness, risk perception, exposure awareness, and health.The findings revealed that the general public had poor awareness of the main components of EDCs and the risks associated with exposure to EDCs. In relation to EDCs, the public’s perceptions of risks were influenced by certain variables such as dangerousness, spontaneity, controllability, fear, familiarity, scientific knowledge, and personal knowledge.Based on these results, this study revealed that it is necessary to establish a harmonized management system for effective risk communication of EDCs.