bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Evolving Approach to Breast Cancer Screening and Treatment in Canada: Implications for Primary Care Providers
Authors: Arthur Greydon , Yong-Hing Charlotte J. , LeVasseur Nathalie 
Published: January 2025

Nearly 30,000 Canadians are diagnosed with breast cancer annually, and while its mortality has decreased by over 55% since the 1970s due to modernized screening technologies and advances in systemic therapy, 5,500 Canadians are estimated to die of the disease every year. Primary care providers are critical through all steps of a patient’s breast cancer journey, from facilitating routine screening, to identifying breast cancer risk factors, ensuring expedient referrals, and recognizing acute or chronic treatment toxicities and their impact on overall physical and psychological health.
The Spectrum of Management for Psoriasis: From the Known to New Alternatives
Authors: Rao Jaggi 
Published: January 2025

Psoriasis is a chronic, immune-mediated systemic condition characterized by inflammatory changes that may involve the skin and joints. It is relatively common, with a prevalence rate of 2–4% in North America, and a global prevalence rate of up to 11.4%. Years ago, affected patients may have ranged in age from 18–39 to 50–69 due to bimodal distribution. While initially thought to be a dermatologic disease, it is now a recognized multisystem condition with a genetic predisposition. The complex pathophysiology is thought to originate from dysregulation between the innate and adaptive immune systems. T-lymphocytes, dendritic cells, cytokines such as interleukin (IL) 23, IL-17, and tumor necrosis factor (TNF) have all been implicated in and contribute to the inflammatory sequelae. The chronicity and pathogenesis of disease may predispose patients to significant functional impairments, associated comorbidities such as metabolic syndrome and cardiovascular disease, and diminished quality of life. This has prompted novel approaches to management with the introduction of biologics and small molecule therapies that address the underlying immune dysregulation.
There are multiple clinical manifestations including plaque psoriasis, guttate psoriasis, erythrodermic psoriasis, and pustular psoriasis. Among the most common is plaque psoriasis which typically presents as symmetrically distributed, well demarcated, erythematous, scaly plaques or patches that may be pruritic. Common sites of involvement include the extensor surfaces of the elbows, knees, the trunk, gluteal cleft, and scalp. Guttate psoriasis is typically preceded by upper respiratory infections and represents approximately 2% of all cases of psoriasis. It involves several small (<1 cm) confetti-like papules and plaques. A severe, although uncommon form is erythrodermic psoriasis which results in widely distributed erythema, scales and exfoliation of a large surface area of the skin. Due to the widespread loss of the epidermal, dermal barrier and associated risk of fluid loss, electrolyte disturbances and infection, it is considered a dermatologic emergency. Pustular psoriasis is also an uncommon, potentially severe, clinical variant, with possible complications secondary to acute widespread erythema and development of multiple pustules.
Update on Insomnia for Primary Care
Authors: Khullar Atul , Swainson Jennifer 
Published: January 2025

Insomnia is a common clinical issue with varying definitions depending on the source. The DSM-V defines insomnia disorder as one or more of: difficulty initiating sleep, maintaining sleep, or early morning wakening with an inability to fall back asleep.
These problems occur despite adequate time allowed for sleep (7 hours), cause dysfunction, and are not attributed to another disorder. The DSM-V then classifies insomnia as either episodic (at least 1 month but less than 3 months), persistent (lasting 3 months or more) and recurrent (2 or more episodes within a year), and considers potential contributing comorbidities.
According to the International Classification of Sleep Disorders (ICSD-3) classification system, symptoms must occur at least 3 times per week, and insomnia is categorized as either short term or chronic. Short-term insomnia disorder in this paradigm (ICSD-3) occurs when the sleep problems have lasted more than 1 but less than 3 months, while chronic insomnia disorder occurs when symptoms persist for more than 3 months.
Adult ADHD: What It Is and How to Assess and Treat It
Authors: Martin Lawrence 
Published: January 2025

4.4% of the adult population, and is also prevalent in 10% of those with depressive or anxiety disorders and in 20% of those with chronic low mood. Among patients referred for treatment-resistant depression, one in three may have undiagnosed ADHD. Overall, ADHD is poorly understood, significantly undertreated, and a common reason for poor response to treatment in mood and anxiety disorders.
ADHD is not a consequence of poor parenting, indulged laziness, or excessive consumption of sugar or food dyes. It is a neurodevelopmental disorder, a “hardwiring” problem, marked by delayed maturation of the Prefrontal Cortex and allied subcortical regions that constitute the “adult” brain.
When we are young, we have limited self-control: we take what we want, say what we think, get excited, cry, and live in the moment. As our brains mature, we learn to control our behaviours, manage our emotional reactions, prioritize tasks, plan, and follow through on those plans. In individuals with ADHD, this maturation is delayed and too often remains incomplete.
Estrategias para fortalecer el turismo rural de la parroquia Zumbahua, cantón Pujilí
Authors: Ugsha Tipán Sonia Maribel , Calvopiña León César Enrique 
Published: January 2025

El presente artículo se sustentó en una investigación que tuvo como objetivo: fortalecer el turismo rural de la parroquia Zumbahua, cantón Pujilí, mediante estrategias alternativa. Se realizó un análisis descriptivo que incluyó técnicas e instrumentos específicos para recopilar los datos necesarios y alcanzar los resultados esperados, se realiza investigaciones de campo y se aplica encuesta. Los datos obtenidos fueron tabulados para su análisis y permitieron arribar a las siguientes conclusiones: Zumbahua tiene un alto potencial para el turismo rural debido a sus atractivos naturales y culturales, especialmente la Laguna de Quilotoa. Los turistas muestran interés en visitar la zona y en general tienen una buena experiencia. La infraestructura turística se percibe como deficiente. Se necesitan mejoras en las vías de acceso, la señalización y la disponibilidad de servicios básicos para que la experiencia del turista sea más satisfactoria. La calidad de los servicios turísticos también necesita mejorar. Capacitar a los prestadores de servicios en atención al cliente, idiomas y gestión empresarial puede contribuir a una mejor experiencia para los visitantes. El turismo tiene un impacto mixto en la comunidad. Si bien genera beneficios económicos y empleo, también existen preocupaciones sobre el aumento del costo de vida, la pérdida de identidad cultural y el impacto ambiental. Es necesario fortalecer la gestión del turismo en Zumbahua con un plan de desarrollo turístico, la promoción de la participación comunitaria y la búsqueda de financiamiento para proyectos turísticos e implementar prácticas de turismo responsable que protejan el medio ambiente y la cultura local.
Diseño de un sistema de Gestión de inocuidad basado en la norma FSSC 22000 (FOOD SAFETY SYSTEM CERTIFICATION) V5.0 para la empresa Lactalis del Ecuador S.A.
Authors: Núñez Orozco Marcia Yolanda , Saigua Maigua Myriam Elizabeth , López Salazar Jesús Ramón , Altamirano Calderón Carmita del Pilar 
Published: January 2025

La presente investigación tuvo como objetivo Diseñar un sistema de gestión de Inocuidad basado en la norma FSSC 22000 (FOOD SAFETY SYSTEM CERTIFICATION) V5.0. para la empresa Lactalis del Ecuador S.A. El enfoque metodológico que se adoptó incluyó varias fases. Primero se organizaron los requisitos previos para las operaciones, incluido el diseño de edificios, el control de alergias y el control de plagas ect. Posterior se implementó el Plan HACCP de acuerdo con la norma FSSC 22000 V5.0, tomando en cuenta ciertos productos lácteos como mantequilla, yogurt, queso crema, leche entera y leche descremada. Para combatir el fraude alimentario, se creó simultáneamente un Programa de Gestión de la Defensa Alimentaria. Los resultados fueron dignos de mención. La auditoría obtuvo una puntuación de 128 puntos, considerándose el 55,50% de conformidades y el 44,50% de no conformidades. Se implementaron programas de seguridad alimentaria para optimizar la gestión de riesgos y la reducción de peligros en todo el proceso de fabricación. La ejecución de los programas tuvo éxito, como lo demuestran los hallazgos, tanto en términos de seguridad alimentaria como de cumplimiento normativo. Para garantizar la eficacia a largo plazo, se sugirió realizar capacitación del personal, esfuerzos de mejora continua y evaluación continua de los procedimientos antifraude. Gracias a esta iniciativa, LACTALIS DEL ECUADOR se ha consolidado como pionero en el sector de productos lácteos, demostrando una fuerte dedicación a la calidad y avances continuos en seguridad alimentaria.
Aplicación de softwares y plataformas digitales para el diagnóstico automotriz preciso; aprovechando el análisis de datos del fabricante
Authors: Vilema Chuiza Fabián Eduardo , Castelo Quinde Silvia Valeria 
Published: January 2025

La evolución de la industria automotriz, trae consigo el incremento de sistemas electrónicos en el automóvil, permitiendo que el proceso de diagnóstico sea más complejo y tome un cambio drástico viendo la necesidad de aplicar herramientas computacionales que permitan reducir las etapas en el diagnóstico electrónico. El presente estudio tiene como objetivo principal analizar la eficiencia del diagnóstico automotriz aplicando plataformas digitales del fabricante en específico, las mismas que permitan direccionar el análisis de los DTC que se localicen durante la etapa de experimentación del vehículo en estudio, considerando que las plataformas de diagnóstico automotriz propias del fabricante ofrecen, análisis de diagramas eléctricos, manuales de reparación, procesos de reprogramaciones para las ECU además de identificar los procesos de averías en donde se aprecian datos exactos que permitan conocer cada uno de los procesos establecidos para los casos en donde la electrónica del automóvil presenta defectos teniendo como consecuencia el funcionamiento fuera de rango del sistema afectado. Para el caso de estudio se procede con la extracción de códigos de avería en un vehículo MHEV de marca KIA, modelo STONIC del año 2024, el cual presenta fallos en la carga de la batería de baja tensión, siendo necesario aplicar los procesos establecidos por el fabricante en su plataforma digital. El método científico aplicado es del tipo cuantitativo con enfoque no experimental considerando que se tomara muestras de información de la unidad de control electrónica de la batería de alta tensión del vehículo pueda entregar bajo estados de fallo y funcionamiento ideal.
PENGEMBANGAN E-MODUL BERBASIS STEM UNTUK MENINGKATKAN KREATIVITAS SISWA DALAM MENGATASI LEARNING LOSS PADA PELAJARAAN MATEMATIKA
Authors: I Komang Sukendra  
Published: January 2025

Kehadiran berbagai fenomena, perubahan kurikulum, metode ajar, dan hal-hal lainnya dapat menyebabkan ketidakstabilan dalam dunia pendidikan. Pada akhirnya, dinamika yang tidak stabil tersebut menyebabkan terjadinya learning loss sehingga perlu carikan solusinya untuk meningkatkan kreativitas belajar siswa. Penelitian ini bertujuan mengembangkan e-modul berbasis STEM yang berkualitas. Jenis penelitian ini adalah penelitian pengembangan dengan model Plomp yang terdiri atas fase investigasi awal, fase desain, fase realisasi/konstruksi, fase tes, evaluasi, revisi, dan fase implementasi. Subjek penelitian siswa kelas XI SMA Negeri 7 Denpasar tahun pelajaran 2021/2022. Kevalidan materi e-modul dinilai oleh ahli materi dan ahli media menggunakan lembar evaluasi dan diuji dengan tabulasi silang Gregory. Hasil evaluasi yang diperoleh menunjukkan bahwa e-modul memenuhi syarat validitas. Hasil uji kepraktisan menunjukkan skor rata-rata nilai kepraktisan oleh siswa sebesar 0,84, dan skor rata-rata nilai kepraktisan oleh guru sebesar 0,85 lebih dari 0,76 berada pada kriteria sangat baik. Keefektifan e-modul dievaluasi dengan memberikan tes hasil belajar matematika siswa dan dianalisis berdasarkan nilai ketuntasan klasikal dan e-modul dinyatakan sudah efektif. Simpulan yang diperoleh e-modul berbasis STEM yang dikembangkan sudah memenuhi unsur validitas, kepraktisan, dan keefektifan serta dapat digunakan dalam pembelajaran matematika materi program linier.
PERSFEKTIF EKONOMI DAN SOSIAL KONSUMEN TERHADAP DAYA BELI BERAS MERAH DAN BERAS PUTIH DI PASAR BAYONGBONG KABUPATEN GARUT
Authors: Nugraha Ade , Sudirman  , Septian Yugi Sadrah , Murwenie Ira 
Published: January 2025

Tujuan penelitian ini untuk membandingkan daya beli beras merah dan beras putih di pasar Bayongbong, Kabupaten Garut. Berdasarkan, perspektif ekonomi dan sosial konsumen. Dapat ditinjau konsumsi beras merah menunjukkan tren peningkatan, seiring dengan kesadaran masyarakat akan pentingnya pola makan sehat. Penelitian ini menggunakan pendekatan kuanitatif untuk mengetahui seberapa besar daya beli konsumen berdasarkan perspektif ekonomi dan social konsumen terhadap kedua jenis beras tersebut, dengan fokus pada aspek ekonomi (harga dan daya beli) serta sosial (kesadaran kesehatan). Hasil penelitian menunjukkan diketahui harga beras merah mampu mempengaruhi daya beli konsumen sebesar 88,0% ) dan beras putih sebesar 83,0% ( ) Artinya, keputusan konsumen dalam membeli beras merah dan beras putih dipengaruhi oleh fluktuasi harga namun didasarkan pada perspektif ekonomi dan social konsumen.
Pengaruh Kualitas Produk Dan Potongan Harga Terhadap Loyalitas Pelanggan: Studi Korelasional Pada Ms Glow Indramayu Store
Authors: Cantika Putri Ayu , Senjaya Aan Juhana , Rizkiyah Tiara Fitri 
Published: January 2025

Kosmetik sudah menjadi kebutuhan bagi seorang wanita untuk mempercantik dirinya, agar dapat tampil cantik dan menarik dengan melakukan perawatan-perawatan menggunakan skincare atau produk kecantikan untuk mendapatkan penampilan yang lebih sempurna. Produk kosmetik sedang marak dipasaran, semakin marak beredar maka semakin banyak pula pesaingnya, untuk itu perusahaan harus mampu memperhatikan dan memberikan produk sesuai dengan yang diinginkan dan dibutuhkan oleh konsumen ataupun pelanggannya. Tujuan penelitian ini untuk menganalisis Pengaruh Kualitas Produk dan Potongan Harga Terhadap Loyalitas Pelanggan pada MS Glow Indramayu Store. Metode yang digunakan dalam penelitian ini menggunakan metode penelitian hubungan (asosiatif research) atau korelasional dengan menggunakan pendekatan kuantitatif. Jumlah sampel pada penelitian ini sebesar 100 pelanggan MS Glow Indramayu Store. Dengan pengumpulan data menggunakan kuesioner. Teknik analisis data menggunakan analisis regresi berganda, korelasi, koefisien determinasi, dan sumbangan relatif antara variabel bebas dengan variabel terikat baik secara sendiri-sendiri maupun bersama. Perhitungan menggunakan alat bantu Software SPSS versi 25. Hasil penelitian menunjukan bahwa terdapat pengaruh Kualitas Produk terhadap Loyalitas Pelanggan secara signifikan, Variansi Kualitas Produk dapat menjelaskan Variansi Loyalitas Pelanggan sebesar 6,4%; terdapat pengaruh Potongan Harga terhadap Loyalitas Pelanggan secara signifikan, Variansi Potongan Harga dapat menjelaskan Variansi Loyalitas Pelanggan sebesar 24,4%; terdapat pengaruh secara bersama-sama Kualitas Produk dan Potongan Harga terhadap Loyalitas Pelanggan secara signifikan, Variansi Kualitas Produk dan Potongan Harga dapat menjelaskan Variansi Loyalitas Pelanggan sebesar 34,2%. Untuk memperbaiki Loyalitas Pelanggan, maka perlu mempertimbangkan dan meningkatkan kembali kualitas produk dan potongan harga.
"ANALISIS GAYA BAHASA SARKASME DALAM KANAL YOUTUBE TRETAN UNIVERSE DENGAN JUDUL EKSLUSIF DEBAT CAPRES "
Authors: Achmad Ferryan Mirza Putra  , Mardiningsih  , Sugianti  
Published: January 2025

Penelitian dengan judul "Analisis Gaya Bahasa Sarkasme Dalam Kanal Youtube Tretan Universe Dengan Judul “Ekslusif Debat Capres” " bertujuan untuk mendeskripsikan bentuk dan makna gaya bahasa sarkasme. Penelitian ini merupakan jenis penelitian deskriptif kualitatif. Data dalam penelitian ini adalah tuturan yang mengandung gaya bahasa sarkasme pada video Channel youtube Tretan Universe dengan judul “Ekslusif Debat Capres”. Sumber data pada penelitian ini adalah video platform youtube dengan judul “Ekslusif Debat Capres”. Berdasarkan fokus penelitian yang ada maka metode pengumpulan data pada penelitian ini menggunakan teknik simak dan catat. Metode yang digunakan pada tahap analisis data adalah teknik induktif, teknik kategorisasi, dan teknik sintesis data. Sedangkan untuk instrumen penelitian peneliti menggunakan tabel pengumpulan data. Pada penelitian ini peneliti menemukan bentuk dan makna gaya bahasa sarkasme diantaranya, sarkasme bentuk penolakan, sarkasme bentuk penyampaian larangan, sarkasme bentuk penyampaian informasi, sarkasme bentuk penyampaian penegasan, sarkasme bentuk penyampaian pendapat, sarkasme bentuk penyampaian perintah, sarkasme bentuk penyampaian pertanyaan, sarkasme bentuk penyampaian persamaan, dan sarkasme bentuk penyampaian perbandingan. Pada penelitian ini, bentuk gaya sarkasme paling banyak ditemukan adalah bentuk penyampaian pendapat. Adapun jenis perubahan makna yang ditemukan pada data diantaranya makna total, makna penghalusan, dan makna pengkasaran. Penelitian ini diharapkan dapat digunakan dalam dunia pembelajaran terutama pada bidang Pendidikan Bahasa dan Sastra Indonesia.
XRD and FTIR characterisation of historical green pigments and their lead-based glazes
Authors: Gražėnaitė Eglė , Kiuberis Jonas , Beganskienė Aldona , Senvaitienė Jūratė , Kareiva Aivaras 
Published: January 2025

In this study, the applicability of X-ray powder diffraction (XRD) analysis and Fourier transform infrared (FTIR) spectroscopy to investigate historical green pigments and their glazes was evaluated. In order to verify the ability to detect pigments in their glazes of the above techniques, the XRD and FTIR analyses were performed on the model samples. The investigation was pursued on nine pigments (Kremer Pigmente): malachite, verdigris, cobalt green, cobalt bottle green, chrome oxide green, Egyptian green, Victorian green, Florentine green and green jasper. The same pigments together with lead oxide and silica were used to prepare lead-based glazes. The results revealed that the XRD analysis is a useful tool for qualitative determination of the composition of glazes, although in some cases other analytical techniques should be involved. However, FTIR spectroscopy in the high wavenumber range (4 000–600 cm–1) does not give reliable results in the determination of green pigments in glazes.
Sol–gel synthesis of calcium nanomaterial for paper conservation
Authors: Darčanova Olga , Beganskienė Aldona , Kareiva Aivaras 
Published: January 2025

Nanoparticles of calcium oxide (100 nm), prepared using the sol–gel citrate method, were sonicated for 20 min in water and used for paper deacidification treatment via the Barrow method. For comparison, deacidification was also performed using bulky calcium hydroxide.Also tested as reagents, were mixtures of the two previously mentioned reagents with the addition of 0.1% gelatin, as well as Bookkeeper alkali material. After thermal accelerated aging at 90 °C for 512 h, all paper samples were investigated by scanning electron microscopy (SEM), infrared (FTIR) and absorbance (UV/Vis) spectroscopy. pH, alkaline reserve (AR), paper sorption and strength properties were determined. The highest value of AR and pH was provided by the calcium nanoparticles treated with gelatin. After artificial aging, the gelatin-treated bulky, nano-sized calcium hydroxide and Bookkeeper alkali material demonstrated an equal decrease in AR and pH. Added gelatin increased the binding of alkali material to paper. Also, measurement of paper strength showed that gelatin treated paper even after aging can resist higher force before breaking. At the same time addition of 0.1% of gelatin did not change paper sorption properties. FTIR and UV/Vis spectra analysis after the artificial aging process confirmed the positive effect of nano-sized calcium hydroxide.
Purification and characterization of polyhydroxybutyrate produced from thermophilic Geobacillus sp. AY 946034 strain
Authors: Giedraitytė Gražina , Kalėdienė Lilija 
Published: January 2025

Thermophilic Geobacillus sp. AY 946034 strain was found to accumulate poly-3-hydroxybutyrate (PHB). The highest PHB percent yield was found under phosphorous limiting conditions (68.9% of cell dry weight), using glucose as the sole carbon source. Higher values of enzyme (ketothiolase, CoA reductase and PHA synthetase) activities of thermophilic strain indicated that bacteria use the classical pathway of PHB biosynthesis when are cultured on glucose as the sole carbon source.The characterization of biopolymer was carried out using FT-IR, DSC and capillary viscosity methods. The FT-IR analysis of the purified polymer revealed similarities in the spectra of the microbial and standard PHB at 2 983, 2 935, 1 722, 1 456, 1 278 and 1 053 cm–1 wave numbers. The thermal analysis showed the accumulated PHB to be semi-crystalline polymer (42%), having a thermal degradation temperature of 280 °C, melting temperature of 168.8 °C and apparent melting enthalpy of 62.98 Jg–1 . Molecular weight of the polymer was found to be 556 kDa.
Polycondensation of hydroxyl-group containing aliphatic diamines and dibromides yielding highly branched poly(2-hydroxypropylene imines)
Authors: Bočkuvienė Alma , Vareikis Aušvydas , Makuška Ričardas 
Published: January 2025

Highly branched poly(2-hydroxypropylene imines) (PHPI) were synthesized by polycondensation of 1,3-diamino-2-propanol and 1,3-dibromo-2-propanol in several polar protic and aprotic solvents.Kinetics of polycondensation was studied using solution calorimetry and conductometric titration, and PHPI were characterized by SEC, 1H and 13C NMR spectroscopy, and DSC. PHPI with the highest degree of branching were synthesized in DMF, while those with the lowest degree in methanol. Independent of the degree of branching, PHPI were not crosslinked and well soluble in aqueous solutions. Presumptive mechanism of branching during polycondensation of aliphatic diamines and dibromides in polar protic and aprotic solvents is presented.
Adsorption of potassium ions on natural zeolite: kinetic and equilibrium studies
Authors: Jaskūnas Andrius , Subačius Benas , Šlinkštienė Rasa 
Published: January 2025

Experimental data show that the adsorption of potassium on clinoptilolite after 7-hour relatively fast start eventually becomes diffusion-controlled and slows down. The rate and capacity of adsorption does not depend on the type of solution used – KNO3 or KCl, but favours higher temperatures. It was found that potassium adsorption is similar to chemisorption and this assumption was confirmed by both equilibrium and kinetic modeling. The applicability of Langmuir and Dubinin–Radushkevich models indicated a non-uniform nature of the clinoptilolite surface and suggested the formation of an adsorbate monolayer, which was used to calculate the clinoptilolite active surface area. The kinetic modeling showed that the pseudo-second order kinetic model was the most suitable for the obtained experimental data, which once more confirmed the chemical nature of potassium adsorption. Despite diffusion-limited potassium adsorption, the release of potassium proceeds at much higher rate in the presence of counter ions and equilibrium can be reached about 10 times faster.