bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to make more people adopt healthy behaviors? Assessing health literacy, health promoting lifestyle and their association of community residents in Shenzhen, China
Authors: Zhang Lei , Liao Jia , Pan Xueyan , Liang Dongmei , Zeng Jinmei , Sun Mingwei , Luo Xiaowen , Ma Xingyu , Yin Mingjuan , Ni Jingdong 
Published: August 2022

IntroductionHealth literacy (HL) has been concerned a key factor for determining the use of health information and promoting health. The study aimed to explore the relationship between different health literacy types and health promoting lifestyle (HPL) in different health literacy population.MethodsThe survey analyzed a sample of 16,921 community residents in Shenzhen. The Chinese Citizen Health Literacy Questionnaire and health-promoting lifestyle profile II (HPLP- II) were used to assess health literacy and health promoting lifestyle.ResultsParticipants were divided into different populations based on the correlation between HL and HPL. The low-HL and medium-HL populations were judged to lack health literacy, and demographic characteristics were significantly different between different HPL levels in low-HL and medium-HL populations. There were 6 types of HL, and health information literacy (β = 0.08, P &lt; 0.001) and chronic disease literacy (β = 0.08, P &lt; 0.001) positively predicted HPL in the low-HL population. In the medium-HL population, the results of reward and punishment analysis showed that health information was a basic factor, chronic disease was performance factor, medical care was a motivating factor for HPL; there were 6 dimensions of HPL, and health responsibility (HR), stress management (SM) and physical activity (PA) were not significantly different in medium-HL population. The results of regression analysis showed that HR and PA had a great impact on HPL (HR: β = 0.193, PA: β =0.179, β for other dimensions was 0.186, 0.176, 0.171, 0.164), but the HR and PA standardized scores were lowest in the HPL dimensions (HR: 69.42, PA: 68.5, lower than other dimensions), so it may be HR and PA that cause HPL unchanged between groups in the medium-HL population.ConclusionsDifferent HL levels have different relationships with HPL, and different HL types have different effects on HPL. Shenzhen community residents need to improve their HL, and they have great potentials for further progress to improve the population health. Public health policy makers need to consider formulating different policies for people with different HL levels.
Evaluation of clinical knowledge and perceptions about the development of thyroid cancer—An observational study of healthcare undergraduates in Saudi Arabia
Authors: Syed Wajid , Samarkandi Osama A. , Alsadoun Ahmed , Harbi Mohammad K. Al , Al-Rawi Mahmood Basil A. 
Published: August 2022

Background and objectiveIn the healthcare context, healthcare personnel are available to help patients according to their requirements. However, having sufficient knowledge of many elements of diseases before graduation may have a good impact on clinical practices later in one's career. As a result, the purpose of this study was to assess the clinical knowledge and perceptions of healthcare students in Saudi Arabia about thyroid cancer (TC).MethodsA cross-sectional study was conducted in King Saud University from August 2021 to November 2021, using a validated self-reporting online survey. The data collection was carried out among senior healthcare students, including pharmacy, nursing, and medical students of both genders, who were Arabic speakers. The data were analyzed using the Statistical Package for the Social Sciences version 26 for Windows (SPSS).ResultsThere were 141 healthcare students who responded, with 46.8% (n = 66) being pharmacy students, 28.4% (n = 40) being nursing students, and 24.8% (n = 35) being medical students. Male participants made up the majority of them (52.5%). Lump or swelling in the neck was described as the most common early indicator of TC by 54.6% (n = 77), followed by difficulty in swallowing by 34.04% (n = 48), and pain in the neck by 24.8% (n = 35). Female participants accounted for 44.7% (n = 63) of those with thyroid dysfunction, according to the study. About 55.3% of the participants (n = 78), reported that they had sufficient knowledge about TC. The knowledge score differed significantly by gender; female participants (60.3%) (n = 47) were more knowledgeable than male participants (30.7%) (n = 31) (p = 0.049).ConclusionThis study depicts that half of the healthcare students thatwere knowledgeable about TC had positive perceptions about the causes of diseases. Furthermore, we also recommend arranging awareness programs for the students by the university officials to overcome the knowledge gap.
Cost-effectiveness analysis of camrelizumab plus chemotherapy as first-line treatment for advanced squamous NSCLC in China
Authors: Shao Taihang , Ren Yinan , Zhao Mingye , Tang Wenxi 
Published: August 2022

ObjectiveResults of CameL-sq has revealed the clinical benefits to patients with advanced squamous non-small-cell lung cancer (sq-NSCLC). This study aims to evaluate the cost-effectiveness of camrelizumab plus chemotherapy to treat sq-NSCLC from the perspective of the Chinese healthcare system.MethodsWe used a partitioned survival model with a lifetime horizon to evaluate the cost-effectiveness of camrelizumab plus chemotherapy vs. chemotherapy in treating sq-NSCLC. Baseline characteristics of patients and key clinical data were extracted from CameL-sq. Costs and utilities were collected from the open-access database and published literature. Costs, quality-adjusted life-years (QALYs), life-years gained, and incremental cost-effectiveness ratios (ICERs) were chosen as economic outcome indicators. We also performed a sensitivity analysis, subgroup analysis, and scenario analysis to verify the stability of the basic analysis results and explore the results under different scenarios.ResultsCombination therapy added 0.47 QALYS and 0.91 life-years with an incremental cost of $6,347.81 compared with chemotherapy, which had an ICER of $13,572 per QALY. The probabilistic sensitivity analysis indicated that camrelizumab plus chemotherapy had a 37.8% probability of cost-effectiveness at a willingness-to-pay threshold (WTP) of 1 time GDP per capital. When WTP was set as 3 times GDP per capital, combination therapy had significant cost-effectiveness. Deterministic sensitivity analysis showed that cost of the best supportive care was the factor with the greatest influence. The subgroup analysis found that combination therapy was associated with cost-effectiveness in several subgroups, namely, patients with disease stage IIIB/IIIC and with PD-L1 tumor proportion score ≤ 1%. Scenario analysis showed that ICER was positively correlated with the price of camrelizumab.ConclusionIn this economic evaluation, camrelizumab plus chemotherapy was unlikely to be cost-effective compared with chemotherapy in the first line therapy of sq-NSCLC from a perspective of the Chinese healthcare system. Reducing the price of camrelizumab and tailoring treatments based on individual patient factors might improve the cost-effectiveness. Our findings may provide evidence for clinicians in making optimal decisions in general clinical practice.
Prevalence of needle-stick injury among nursing students: A systematic review and meta-analysis
Authors: Xu Xu , Yin Yu , Wang Hao , Wang Fengxia 
Published: August 2022

IntroductionNeedle-stick injuries (NSI) are a serious threat to the health of healthcare workers, nurses, and nursing students, as they can expose them to infectious diseases. Different prevalence rates have been reported for this type of injury in different studies worldwide. Therefore, this study aimedto estimate the pooled prevalence of NSI among nursing students.MethodsThis study was conducted by searching for articles in Web of Science, PubMed, Scopus, Embase, and Google Scholar without time limitation using the following keywords: needle-stick, needle stick, sharp injury, and nursing student. The data were analyzed using the meta-analysis method and random-effects model. The quality of the articles was evaluated with Newcastle-Ottawa Quality Assessment Scale (NOS). The heterogeneity of the studies was examined using the I2 index, and the collected data were analyzed using the STATA Software Version 16.ResultsInitially, 1,134 articles were retrieved, of which 32 qualified articles were included in the analysis. Nursing students reported 35% of NSI (95% CI: 28–43%) and 63% (95% CI: 51–74%) did not report their needle-stick injuries. The highest prevalence was related to studies conducted in Asia (39.7%; 95% CI: 31.7–47.7%). There was no significant correlation among NSI prevalence and age of samples, and article year of publication.ConclusionA third of nursing students reported experiencing NSI. Consequently, occupational hazard prevention training and student support measures need to be considered.
Impact of alcohol-induced intestinal microbiota dysbiosis in a rodent model of Alzheimer’s disease
Authors: Frausto Dulce M. , Engen Phillip A. , Naqib Ankur , Jackson Aeja , Tran Laura , Green Stefan J. , Shaikh Maliha , Forsyth Christopher B. , Keshavarzian Ali , Voigt Robin M. 
Published: August 2022

Introduction: Alzheimer’s disease (AD) is a devastating neurodegenerative disorder. While genetics are important in the development of AD, environment and lifestyle are also important factors influencing AD. One such lifestyle factor is alcohol consumption. Unhealthy and excessive chronic alcohol consumption is associated with a greater risk of all types of dementia, especially AD. Alcohol consumption has numerous effects on the body, including alterations to the intestinal microbiota (dysbiosis) and intestinal barrier dysfunction (leakiness and intestinal hyperpermeability), with evidence indicating that inflammation resulting from dysbiosis and barrier dysfunction can promote neuroinflammation impacting brain structure and function.Objective: This study sought to determine the impact of alcohol-induced dysbiosis and barrier dysfunction on AD-like behavior and brain pathology using a transgenic rodent model of AD (3xTg-AD).Methods: Alcohol (20%) was administered to 3xTg-AD mice in the drinking water for 20 weeks. Intestinal (stool) microbiota, intestinal barrier permeability, systemic inflammation (IL-6), behavior, and AD pathology (phosphorylated tau and β-amyloid), and microglia were examined.Results: Alcohol consumption changed the intestinal microbiota community (dysbiosis) and increased intestinal barrier permeability in both control and 3xTg-AD mice (oral/urine sugar test and lipopolysaccharide-binding protein (LBP)). However, alcohol consumption did not influence serum IL-6, behavior, or β-amyloid, phosphorylated tau, or microglia in 3xTg-AD mice. Important differences in genotype and sex were noted.Conclusion: Alcohol-induced microbiota dysbiosis and intestinal barrier dysfunction did not exacerbate behavior or AD-like brain pathology in the 3xTg-AD mouse model of AD which could, in part, be the result of a lack of systemic inflammation.
High flow nasal cannula for patients undergoing bronchoscopy and gastrointestinal endoscopy: A systematic review and meta-analysis
Authors: Tao Yuan , Sun Mingyang , Miao Mengrong , Han Yaqian , Yang Yitian , Cong Xuhui , Zhang Jiaqiang 
Published: August 2022

BackgroundHigh flow nasal cannula is gaining increasingly used in patients undergoing endoscopic procedures. We undertook this systematic review and meta-analysis to determine whether high flow nasal cannula (HFNC) could effectively minimize the risk of hypoxemia as compared with conventional oxygen therapy (COT).MethodsWe performed a comprehensive search of Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, and Web of Science. Studies involving the application of HFNC during endoscopic procedures were identified.ResultsWe included 15 randomized controlled trials (7 bronchoscopy, 8 gastrointestinal endoscopy). Patients receiving HFNC during endoscopic procedures had a significantly lower risk of hypoxemia (defined as SpO2 &lt; 90%) versus COT group (risk ratio = 0.32; 95%CI (0.22–0.47), 13 studies, 4,093 patients, moderate-quality evidence, I2 = 48.82%, P &lt; 0.001). The lowest SpO2 was significantly higher in HFNC group (mean difference = 4.41; 95%CI (2.95–5.86), 9 studies, 1,449 patients, moderate-quality evidence, I2 = 81.17%, P &lt; 0.001) than those receiving COT. No significant difference was detected between groups in end-procedure partial pressure of CO2 (standard mean difference  =  −0.18; 95%CI (−0.52–0.15), 5 studies, 238 patients, moderate-quality evidence, I2 = 42.25%, P = 0.29). Patients receiving HFNC were associated a lower need for airway intervention (risk ratio = 0.45; 95%CI (0.24–0.84), 8 studies, 2,872 patients, moderate-quality evidence, I2 = 85.97%, P = 0.01) and less procedure interruption (risk ratio = 0.36; 95%CI (0.26–0.51), 6 studies, 1,562 patients, moderate-quality evidence, I2 = 0.00%, P &lt; 0.001). The overall intubation rate after endoscopy was 0.20% in both group, with no difference detected (risk ratio = 1.00; 95%CI (0.30–3.35), 7 studies, 2,943 patients, low-quality evidence, I2 = 0.00%, P = 1.00).ConclusionThis systematic review and meta-analysis found moderate to low evidence that the application of HFNC was associated with improved oxygenation, decreased need for airway intervention, and reduced procedure interruption in patients undergoing endoscopic procedures. Future larger sample and high-quality studies are warranted to confirm our result and further investigate the effectiveness of HFNC in patients at risk.
Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42022298032.
Combining the Water–Energy–Food and Food Waste–Food Loss–Food Security Nexuses to Reduce Resource Waste
Authors: Skawińska Eulalia , Zalewski Romuald I. 
Published: August 2022

The availability of water, energy and food plays a key role in meeting the basic needs of the world population and allowing them to achieve prosperity and supports the UN’s sustainable development goals (SDGs). These three fundamental resources are closely interrelated, with their deep interdependencies reflected in various concepts of the ‘water–energy–food nexus’ (W–E–F). One-third of the total food produced globally results in food loss and waste (FL and FW), which also means the waste of resources used for their production, mainly energy and water. We thus propose a fusion of the W–E–F nexus and the FS–FW–FL nexus to achieve a better correlation between food production and food consumption in order to avoid additional negative effects. We explore the research problem of how the availability of water, energy and food resources can be improved by reducing FW and FL. The objective of this paper is to present an overview of opportunities to reduce the negative effects of FWL. The review paper is based on a comprehensive analysis of the literature, exploration of various (basic and extended) W–E–F models and their linkages with SDG and the entirety of the food supply chain from field to table. In addition to a literature analysis, we applied comparative methods, modeling, visualization and basic indicators of descriptive statistics. Although the amount of literature on this topic is growing, we found that systematic knowledge is still scarce, with each new study putting forth yet more new solutions. Although the data in various studies show somewhat different results, we conclude that reducing FW and FL has a positive, harmonizing effect on the W–E–F nexus.
Yellow Twig (Nauclea orientalis) from Thailand: Strictosamide as the Key Alkaloid of This Plant Species
Authors: Songoen Weerasak , Brunmair Julia , Traxler Florian , Wieser Viktoria Chiara , Phanchai Witthawat , Pluempanupat Wanchai , Brecker Lothar , Schinnerl Johann 
Published: August 2022

Comprehensive phytochemical examination from different perspectives using preparative and analytical chromatographic techniques combined with spectroscopic/spectrometric methods of the so-called “yellow twig” Nauclea orientalis (L.) L. (Rubiaceae) led to the identification of 13 tryptamine-derived (=monoterpene-indole) alkaloids. The identified alkaloids comprise strictosamide and four of its glucosidic derivatives, three oxindole derivatives, and five yellow-colored angustine-type aglycones. Qualitative and quantitative HPLC analyses showed the enrichment of strictosamide in all studied organs. Based on these results, we performed metabolomic analyses of monoterpene-indole alkaloids and made a 1H NMR in vitro monitoring of enzymatic deglucosylation of strictosamide. A comparison of the stability of strictosamide and its enantiomer vincoside lactam by theoretical calculations was also performed revealing a slightly higher stability of vincoside lactam. Additionally, we conducted two different anti-feedant assays of strictosamide using larvae of the polyphageous moth Spodoptera littoralis Boisduval. The obtained results indicate that generally two different biosynthetic pathways are most likely responsible for the overall alkaloid composition in this plant. Strictosamide is the key compound in the broader pathway and most likely the source of the identified angustine-type aglycones, which may contribute significantly to the yellow color of the wood. Its cross-organ accumulation makes it likely that strictosamide is not only important as a reservoir for the further biosynthesis, but also acts in the plants’ defense strategy.
The Role of Community Colleges in Developing Creativity and Innovation Skills of Vocational Students ( The University College of Applied Science as a Case Study)
Authors: Abusamra Asmaa 
Published: August 2022

This study aims to identify the role of community colleges in developing innovation and creativity skills among the students who are enrolled in its vocational programs from their point of view according to the study variables of gender, age and province in the second semester of the academic year 2018/2019. Furthermore, it sheds lights upon the efforts paid by community colleges in order to develop the skills of innovation and creativity in their various vocational programs. In order to achieve the study purposes, the quantitative method is used and a questionnaire as a study tool has been developed, distributed among the study sample and analysed by (SPSS). The results indicate that the arithmetic average of all the questionnaire’s items reaches (3.98) and thus the relative weight is (79.65). This means that there is a great deal of agreement on the questionnaire in general. The study also showed that there are no statistically significant differences between the averages of the study sample responses in all areas of the questionnaire for the role of the University College of Applied Sciences in developing innovation and creativity skills for vocational students according to their views, which are attributed to the variables of the study with the exception of age and province .The study recommends the need to provide a range of physical and moral facilities in the vocational institution’s environment, which support the enhancement of the creativity and innovation growth of technical and academic staff, vocational curriculum and the management practices and policies
Professional social rating as an innovative tool for reducing losses in the water transport economy
Authors: Neustupova A. S. , Koniagina M. N. 
Published: August 2022

Aim. The presented study aims to analyze the statistics of water transport accidents to identify the most common cause of such accidents and to propose an innovative solution to this problem. Tasks. The authors investigate the frequency of water transport accidents in 2017–2021; systematize their causes and identify the most common ones; examine the statutory regulation and supervision of water transport; identify its drawbacks and propose an unconventional solution to the problem of regulation and supervision of water transport, which can be considered as innovative. Methods. This study uses general scientific methods of cognition: analysis, synthesis, generalization, visualization, and forecasting to analyze data on water transport accidents in 2017–2021, establish cause-and-effect relationships of accidents, and predict the dynamics of individual indicators. Results. Data on water transport accidents are grouped, the causes of accidents on river and sea vessels are ranked, and the vector of changes in the accident rate is predicted (adjusted for the COVID-19 coronavirus pandemic). The authors propose the idea of combating the main cause of most water accidents – the human factor. Conclusions. The human factor causes 74% of water transport accidents, and existing methods of supervision and control are not effective enough. Therefore, it is necessary to introduce a professional social rating for workers and employees in water transport and its infrastructure. This will make it easier for shipowners to hire personnel, improve control and supervisory procedures and investigation of incidents, and increase the motivation of personnel to perform their duties diligently, while also positively affecting the level of safety and economic efficiency of water transport enterprises and their infrastructure. This proposal seems appropriate in the context of the national project “Digital Economy”.
Transformation of the national medical services market: A review of the works of modern Russian authors
Authors: Elokhina L. N. 
Published: August 2022

Aim. The presented study aims to assess the current state and possible vectors of changes in the Russian medical services market by analyzing the results of secondary data of Russian researchers. Tasks. The authors analyze existing scientific and theoretical approaches to the problem under consideration; identify patterns in the development of the medical services market in Russia; determine regulatory mechanisms for the medical market. Methods. This study is based on multidisciplinarity, methods of related scientific disciplines, quantitative and qualitative tools. The diversity of research tools is due to the specifics of a particular subject area and its social necessity. Results. The structure of the medical services market, which includes related sectors associated with the development of pharmaceutics, medical equipment, and specialized software, poses a wide range of challenges for researchers. There is an ongoing discussion in the Russian scientific community about the mechanisms for the incentivization of such a market. The number of publications by Russian authors on this problem is growing. Conclusions. Competition in the medical services market is caused by the existence of public and private medicine (some researchers also distinguish the informal shadow sector). The emergence of competition has a positive effect on the quality of medical care and medical services, making it possible to enhance the prestige of the medical profession and the income of medical workers. However, there are also specific regional problems related to pricing in private medicine and compliance with quality standards. Other significant issues include overcoming the existing state paternalism and forming a new perception of medical services in general, which most consumers in Russia find difficult to accept.