bluuebunny/crossref_metadata_2025_split huggingface dataset:
A proposed hybrid root cause analysis technique for medical quality control of gynecological endoscopy–a cross-sectional study on China
Authors: Zheng Hui , Lin Yanying , Yi Huan , Zheng Xiangqin 
Published: April 2022

Abstract
Objective To find out the key factors affecting the medical quality of gynecological endoscopy, and clarify the characteristics and intensity of the factors. To explore the feasibility of the application of new analytical tools in medical quality control.Methods This cross-sectional study was conducted in the eighth Session of The Quality Control Committee of Gynecological Endoscopy of Fujian Province, China in January 2022. Twenty-three gynecological endoscopy quality control experts who attended the conference filled in the questionnaire on site. Using the new analysis model constructed by total interpretative structure model (TISM) and cause and effect diagram (CED), 20 potential factors of gynecological endoscopy medical quality were analyzed to find the core factors affecting medical quality.Result Among the 20 potential factors affecting the medical quality of gynecological endoscopy, 9 factors with strong influence were screened out. Lack of quality control personnel, lack of regular personnel assessment and training, insufficient support of relevant departments and lack of beds are the high-level driving factors affecting the medical quality of gynecological endoscopy. Inadequate management of surgical grading, improper authorization of operation, insufficient personnel experience and insufficient hospital quality control supervision are the factors of medium-level connection. The high-level driving factors have the most significant impact on medical quality, which needs to be paid more attention, followed by the medium-level connecting factors.Conclusion The TISM-CED model is an effective tool to trace the core factors and clarify the characteristics and order of factors, which can be applied to medical quality control.
LncRNA-ADAM11 regulates the vascular endothelial cell senescence and promotes the development of intracranial aneurysm via MiR-223-3p/NLRP3 pathway
Authors: Zhen Yong , Yan Ke , Zhou Xinzhi , He Liang , Song Bingwei , He Jiawei , Hu Kai , Shen Linhai 
Published: April 2022

Abstract
Intracranial aneurysms (IAs) are the localized dilatations of intracranial arteries because of the weaknesses of the endothelial layer. It causes subarachnoid hemorrhage (SAH), which accounted for 80% of total SAH and has 50% fatality rate. Cell senescence, especially endothelial cells senescence, is closely related to the occurrence of vascular diseases. However, the relationship of endothelial cell senescence and IAs have not well defined. It is reported that circulating exosomes and exosomes-derived lncRNAs involved in the process of various diseases. LncRNAs expression aberrant in serum and IAs tissues from IA patients has been confirmed. However, the relationship of serum exosomes-derived lncRNAs and endothelial cell senescence in IAs has unclearly. Therefore, the current study aims to investigate the roles and underlying mechanisms of circulating exosomes-derived lncRNA in the senescent endothelial cells of IAs. In this study, we used ligation operation to construct IA rats. We also isolated and cultured endothelial cells from rat’s ACA/OA bifurcation. The blood pressure was detected to confirm the IA rats construction. HE staining and SA-β-gal staining was used to detect the pathologic of aneurysm and cell senescence. The expression of senescence marker genes and NLRP3 inflammasome-related genes was detected by western blot. ELISA was used to detect the expression levels of inflammatory factor. Immunofluorescence was used to confirm the cell type of senescence. Differential expression lncRNAs were identified by RNA sequencing in exosomes from clinical samples. Exosomes-derived lncRNA function was confirmed through co-culture and overexpression or knockdown lncRNA. Luciferase reporter assay and RIP assay confirmed the target binding of miRNA and lncRNA. Rescue experiments were performed to confirm lncRNA-miRNA-mRNA mechanism in endothelial cell senescence. The present study found that NLRP3 involved in the process of endothelial cell senescence in IAs. Exosomes from IA patient’s peripheral blood promoted endothelial cells senescence through transferring lncRNA ADAM11. In mechanism, lncADAM11 promoted endothelial cells senescence through competing bind to miR-223-3p and further promoting the expression of NLRP3. In conclusion, circulating exosomes-derived lncRNA ADAM11 regulated the senescence of vascular endothelial cells and promoted the development of IA via miR-223-3p/NLRP3 axis.
Analysis and Comparison of Coarray Based Sparse Arrays
Authors: Epcacan Erdal , Ciloglu Tolga 
Published: April 2022

Abstract
The study of sparse linear arrays has started in the 1960’s and remains a hot topic. Since then, the problem has been approached in a variety of ways, and many different optimization algorithms have been used to design sparse arrays. In the early years of sparse array research, in addition to other methods that involve array pattern related measures, the problem had been handled in terms of the coarray structure. Such methods do not directly involve pattern-based objectives, and in some cases, they have closed-form structures; we call these methods as coarray based methods. Nowadays, coar-ray based methods are attracting considerable attention again. In this paper, the analysis and comparison of the most commonly known ones of those arrays are conducted. Moreover, the necessity and the success of those arrays are discussed by chasing answers to two questions with simulation results. First, while keeping the number of sensors fixed what is the optimum layout? Secondly , while keeping the aperture fixed what is the optimum number of sensors to be used?
Cylindromatosis suppression enhances rheumatoid arthritis fibroblast-like synoviocyte-induced osteoclastogenesis and bone resorption by promoting nuclear factor-κB and c-Jun N-terminal kinase activation
Authors: Zhou Jing-jing 
Published: April 2022

Abstract
Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease. Cylindromatosis (CYLD) is a tumor suppressor that negatively regulates nuclear factor-κB (NF-κB) activation. We aimed to investigate both the effect and mechanism of CYLD-dependent RA-fibroblast-like synoviocyte (FLS)-induced osteoclastogenesis and bone resorption. Results: (1) The CYLD mRNA of peripheral blood mononuclear cell (PBMC）was significantly downregulated in the RA group compared with that in the healthy control group. (2) Co-culture with RA-FLSs induced PBMC osteoclastogenesis and bone resorption. The mRNA and protein levels of CYLD, TRAP, c-fos, CTSK, CALCR, MMP-9, and NFATc1 were increased in osteoclast precursors and osteoclasts. (3) RANKL-induced CYLD expression during osteoclastogenesis was shown to be NF-κB-dependent. (4) Downregulation of CYLD expression in PBMCs could in turn significantly increase the number of osteoclasts, enhance the resorption lacunae area on bone slices, and exaggerate TRAP activity, when compared with that of the negative control. CYLD suppression could significantly increase the mRNA and protein levels of TRAP, c-fos, CTSK, CALCR, MMP-9, and NFATc1, as well as the phosphorylation of NF-κB and c-Jun N-terminal kinase (JNK) in PBMCs and osteoclasts. Conclusions: Our results highlight CYLD as a negative regulator of RA-FLS-induced osteoclastogenesis and bone resorption.
An intuitive picture of the Casimir effect
Authors: Hodgson Daniel , Burgess Christopher , Altaie M , Beige Almut , Purdy Robert 
Published: April 2022

Abstract
The Casimir effect, which predicts the emergence of an attractive force between two parallel, highly reflecting plates in vacuum, plays a vital role in various fields of physics, from quantum field theory and cosmology to nanophotonics and condensed matter physics. Nevertheless, Casimir forces still lack an intuitive explanation and current derivations rely on regularisation procedures to remove infinities. Starting from special relativity and treating space and time coordinates equivalently, this paper overcomes no-go theorems of quantum electrodynamics and obtains a local relativistic quantum description of the electromagnetic field in free space. When extended to cavities, our approach can be used to calculate Casimir forces directly in position space without the introduction of cut-off frequencies.
Dimensions of Morphological Integration
Authors: Bookstein Fred L. 
Published: April 2022

Abstract
Over several generations of evolutionary and developmental biologists, ever since Olson and Miller's pioneering work of the 1950's, the concept of “morphological integration” as applied to Gaussian representations N (μ, Σ) of morphometric data has been a focus equally of methodological innovation and methodological perplexity. Reanalysis of a century-old example from Sewall Wright shows how some fallacies of distance analysis by correlations can be avoided by careful matching of the distance rosters involved to a different multivariate approach, factor analysis. I reinterpret his example by restoring the information (means and variances) ignored by the correlation matrix, while confirming what Wright called “special size factors” by a different technique, inspection of the concentration matrix Σ-1. In geometric morphometrics (GMM), data accrue instead as Cartesian coordinates of labelled points; nevertheless, just as in the Wright example, statistical manipulations do better when they reconsider the normalizations that went into the generation of those coordinates. Here information about both μ and Σ, the means and the variances/covariances, can be preserved via the Boas coordinates (Procrustes shape coordinates without the size adjustment) that protect the role of size per se as an essential explanatory factor while permitting the analyst to acknowledge the realities of animal anatomy and its trajectories over time or size in the course of an analysis. A descriptive quantity for this purpose is suggested, the correlation of vectorized μ against the first eigenvector of Σ for the Boas coordinates. The paper reanalyzes two GMM data sets from this point of view. In one, the classic Vilmann rodent neurocranial growth data, a description of integration can be aligned with the purposes of evolutionary and developmental biology by a graphical exegesis based mainly in the loadings of the first Boas principal component. There results a multiplicity of morphometric patterns, some homogeneous and others characterized by gradients. In the other, a Vienna data set comprising human midsagittal skull sections mostly sampled along curves, a further integrated feature emerges, thickening of the calvaria, that requires a reparametrization and a modified thin plate spline graphic distinct from the digitized configurations per se. This new GMM protocol fxulfills the original thrust of Olson and Miller's (1951) “ρF-groups,” the alignment of statistical and biological explanatory guidance, while respecting the enormously greater tange of morphological descriptors afforded by well-designed landmark/semilandmark configurations.
A Comprehensive Summary on the Enhancement of Characteristics of Reinforced Concrete by Employing Polypropylene Materials
Authors: J Anto , M Bhuvaneshwari 
Published: April 2022

Abstract
The scientific community is currently confronted with critical problems in providing a healthy world for future generations. The study for sustainable plastic recycling methods is difficult for a variety of purposes. Indeed, during the previous century, the widespread usage of plastic materials has resulted in vast amounts of long-lasting waste that has remained largely unaddressed by effective collection and disposal policies. Packaging materials are responsible for the majority of this waste which also includes polypropylene materials. However, environmental concerns imposed a new trend in the previous decade that brought this topic under the microscope, as seen by the growing number of linked publications. For the recycling of polymeric plastic materials, several chemical and mechanical methodologies have been proposed. Due to the low ultimate tensile strain of concrete, plastic waste fibre materials have been used in concrete in recent times as the reinforced concrete components often function with cracks during the serviceability phase. The bonding strength and stress variation during flexure are investigated, and also the toughening effect of a hybrid combination of steel and polypropylene fibres on high-strength concrete. Polypropylene's compressive and tensile strength, good dielectric characteristics, and acid and alkali resistance have all been explored in various studies. Hence this most promising recycled polypropylene fibre (PPF) needs focus to be investigated in the construction industry.
A rare left ventricular cardiac myxoma mimicking fibroma: A case report
Authors: Xia Liang-Yan , Zhu Hong-Ling , Li Rong-Hang , Pan Xiao-Hua , Liu Bo , Xu Jing 
Published: April 2022

Abstract
Background: In most cases, it is not difficult to differentiate common left ventricular (LV) cardiac myxomas from fibromas because they are different disease entities and have different imaging findings. Herein, we present a case of a tumor with histological characteristics of a LV cardiac myxoma even though its imaging and macroscopical views were similar to that of fibroma.Case presentation: A 65-year-old woman was admitted to the hospital with chest tightness and palpitations which persisted for 2 years. Transthoracic echocardiogram (TTE) and transesophageal echocardiography (TEE) revealed a 23 mm × 8 mm, polyp-like-shaped, homogeneous, firm, solitary, mobile and solitary LV mass, which protruded into the left atrium during systole, resulting in mild mitral regurgitation. LV contrast-enhanced echocardiography revealed that there was little contrast agent filling in the LV mass. To further clarify the nature of the mass, non-enhanced and contrast-enhanced coronary computed tomography (CT) angiograms showed a 19 mm × 8 mm relatively homogeneous low density with punctate calcifications mass and no significant enhancement. Thus, we preoperatively diagnosed her condition as a LV fibroma and performed excision of the tumor under cardiopulmonary by-pass by using port-access approach through right mini-thoracotomy. The postoperative pathological diagnosis of the tumor was in fact a LV myxoma.Conclusions: LV cardiac myxomas mimicking fibroma makes diagnosis difficult, and pathology is the gold standard for the diagnosis of myxoma. Complete surgical resection is the first choice to treat LV myxomas.
Probability wave is a real wave, a double helix electrical field carried by the charged elementary particle and the nuclei
Authors: Chen Sennian 
Published: April 2022

Abstract
Steven Weinberg, one of the founders of the Standard Model of Physics, asked years ago [1]: is the wave function of quantum mechanics real, or is it just used by scientists to calculate? We try to find the answer. We study the general solution of the Schrödinger equation mathematically. We will prove that for satisfying the Schrödinger equation, the particle should possess a helical structure of mass density. Then we will prove further that (i) charged elementary particles and atomic nucleus fall into two categories: they have charge or, but different directions of charges helices, like right-handed electron and left-handed electron etc. (ii) Charge (or) distributes double helically on the particle side boundary. It generates and carries a double helix external electric field with the same velocity. (iii) This E-wave will be proved is just the de Broglie wave. (iv) Its function is particle’s state function in quantum mechanics. (v) Charged particle itself and the de Broglie E-wave it carries form a particle-wave hybrid structure. The E -wave exhibits all the possible states and probabilities; as for the particle itself it can take only one basis state randomly, such as at an eigen state in the atom and molecular or at a point on the interference pattern. (vi) The orbital motion of an electron in the lower energy layers of atom and molecule does not radiate EM energy to collapse into the nucleus. (vii) Self-interference of the hybrid structure can better explain the single particle double-slit interference
Effect of mammography screening on long-term survival of breast cancer patients: Results from the National Cancer Screening Program in Korea
Authors: Luu Xuan Quy , Lee Kyeongmin , Jun Jae Kwan , Suh Mina , Jung Kyu-Won , Choi Kui Son 
Published: April 2022

Abstract
BackgroundBreast cancer (BC) is the most commonly diagnosed cancer type globally with the geo-ethnic differences in BC epidemiology. Therefore, many countries have adopted national cancer screening programs to reduce the burden of BC. Currently, the Korean National Cancer Screening Program provides biannual mammography screening for women aged ≥40 years. However, there were limited Asian studies investigating the effect of mammography screening, especially study with the long-term follow-up. Our study investigated the effect of mammography on the long-term survival of BC patients aged 40 years or older according to the screening history and duration since screening. MethodsThe study cohort was organized from three nationwide databases of the Korean National Cancer Screening Program, the Korean Central Cancer Registry, and death certificates. We included 24,387 women diagnosed with invasive cancer or ductal carcinoma in situ in 2008 and 2009 and followed up until December 31, 2019. The Kaplan–Meier analysis and the log-rank test were used to compare the survival of the subgroups. Cox proportional-hazards regression was used to investigate the effect of BC screening on mortality.ResultsOverall, 20,916/24,387 patients (85.8%) were alive at the end of the follow-up period (median: 10.5 years). The long-term survival rate was significantly lower in the never-screened group (80.3%) than in the screened group (88.9%) (P<0.001). The survival rate ranged from only 22.4% in patients with distant stage to 96.4% in DCIS patients. A 35% BC mortality reduction (hazard ratio [HR]=0.65, 95% confidence interval [CI]=0.60–0.70) from screening was observed. Subgroup analysis based on cancer stage showed reductions of 62%, 36%, and 24% for subgroups of localized stage, regional stage, and distant stage, respectively. Women aged 40–49 years received the least benefit from BC screening (HR=0.71, 95% CI=0.62–0.81).ConclusionsMammography screening was effective in reducing the risk of BC-specific death in Asian women across all cancer stages. However, this effect was relatively small among women in their 40s, suggesting that more detailed and specialized screening strategies are needed.
Impact of COVID-19 Pandemic on Singapore’s Aviation Industry
Authors: Rangaswamy Easwaramoorthy , Hoe Winston Hoo Kian , Nawaz Nishad 
Published: April 2022

Abstract
COVID-19, a global pandemic, is proving a significant threat to various sectors globally, including the aviation industry. There has been limited research on the Singapore aviation industry, their responses and preparedness and the impact of COVID-19 during and post-pandemic. With such a gap in the literature, this study aims at understanding the impact that the pandemic has specifically on Singapore’s aviation industry both current and in the future while focusing on the existing mitigation measures. A survey questionnaire was used to collect quantifiable data from airport and non-airport workers to analyse various attributes, such as the perception of mitigation and air travel demand. The results concluded that attitudes towards pandemic and mitigation measures significantly led to better expectations of air travel recovery. It is to be noted that beyond domestic and global attitudes, rebound of international travel essentially relies on borders to be opened and multiple countries’ collaboration and coordination.
Using an Explicit Query and a Topic Model for Scientific Article Recommendation
Authors: smail Boussaadi 
Published: April 2022

Abstract
The search for relevant scientific articles is a crucial step in a scientific research project. However, the considerable number of articles published and uploaded online in digital databases (such as google scholar, semantic scholar, etc.) makes this task tedious and negatively impacts the researcher's productivity. This article proposes a new method of recommending scientific articles, taking advantage of content-based filtering. The challenge is to target the relevant information to meet the researcher's needs regardless of his research's domain. Our recommendation method has based on a semantic exploration using the latent factors. Our goal is to achieve an optimal topic model, which will serve as the basis for the recommendation process. Experiences confirm our performance expectations by showing relevance and objectivity in the results.
Clinical Utility and Correlates of Cerebrospinal Fluid 14-3-3 Protein in the Evaluation of Rapid Progressive Dementia
Authors: Kong Yu , Chen Zhongyun , Liu Li , Chu Min , Cui Yue , Xie Kexin , Zhang Jing , Wu Li-yong 
Published: April 2022

Abstract
Background
The 14-3-3 protein in cerebrospinal fluid (CSF) is a suitable marker for the differential diagnosis of patients with rapidly progressive dementia (RPD) suspected of Creutzfeldt-Jakob disease (CJD). However, the CSF 14-3-3 protein has also been detected in various non-prion-related RPD. Our objective was to investigate the general distribution of RPD with positive 14-3-3 result and to evaluate the association between CSF 14-3-3 protein and the clinical features, auxiliary examination and prognosis in patients with RPD.
Methods
A total of 317 patients with RPD were enrolled in this study and followed-up for at least 2 years. The clinical, auxiliary examination and prognostic data were collected. The CSF 14-3-3 test was performed for all patients, and the distribution of various diseases with a positive 14-3-3 result was analyzed. The patients were divided into the CJD and non-prion RPD groups, and the association of CSF 14-3-3 with clinical features, auxiliary examination and prognosis were tested in both groups.
Results
The 14-3-3 protein test was positive in a broad spectrum of diseases with RPD, and the most frequent diagnosis was CJD, followed by non-prion disorders like autoimmune encephalitis and neurodegenerative disease. In the CJD group, the positive rate was 50.3%, and CSF 14-3-3 protein was associated with shorter survival (p = 0.031), advanced stage (p = 0.018), and visual (p = 0.045) and cerebellar dysfunction (p = 0.025). In the non-prion RPD group, the positive rate was 23.3%, and 14-3-3 protein was more common in the older patients (p = 0.028) and those presenting myoclonus (p = 0.008).
Conclusions
The clinical characteristics of patients with positive 14-3-3 test differed significantly from those with the negative result in both the CJD and non-prion RPD groups. In the non-prion RPD group, CSF 14-3-3 protein was more common in patients with myoclonus.