bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innate triggering and antiviral effector functions of Activin A
Authors: Al-Hourani Kinda , Ramamurthy Narayan , Marchi Emanuele , Eichinger Ruth , Li Lian , Fabris Paolo , Drakesmith Alexander Hal , Klenerman Paul 
Published: August 2022

Background: First-line defence against viral infection is contingent upon rapid detection of conserved viral structural and genomic motifs by pattern recognition receptors, followed by activation of the type I IFN response and establishment of an antiviral state. Novel antiviral functions of bone morphogenetic protein and related activin cytokines, acting in conjunction with, and independently of, type I IFN, have recently been described. How these antiviral effects are mediated and triggered by viral infection has not been defined. Methods: Microarray and RNAseq data from hepatoma-derived cell lines stimulated with Activin A in vitro were interrogated both by pathway analysis and for evidence of IFN-stimulated gene induction. Liver tissue obtained from patients with chronic HCV were examined by real-time quantitative polymerase chain reaction (RT-qPCR) for evidence of Activin A induction. Activin expression by peripheral blood mononuclear cells exposed to nucleic acid analogues was quantified by RT-qCR, whereas induction dynamics in acute infection was investigated in in vitro Sendai virus infection and a murine influenza A. Results: Transcriptomic analyses delineated strikingly congruent patterns of gene regulation in hepatocytes stimulated with recombinant Activin A and IFNα in vitro. Activin A mRNA, encoded by INHBA, is induced upon activation of RIG-I, MDA5 and TLR7/8 viral nucleic acid sensors in vitro, across multiple cell lines and in human peripheral blood mononuclear cells. In vivo, imurine influenza A also upregulated Inhba mRNA in the lung; this local upregulation of Inhba is retained in MAVS knockout mice, indicating roles for non-RIG-I-like receptors in its induction. Activin induction and signalling were also detectable in patients with chronic viral hepatitis. Conclusions: These data suggest Activin A is triggered in parallel with type I IFN responses and can trigger related antiviral effector functions, with implications for the development of targeted antiviral therapies and revealing novel facets of Activin biology.
School and community driven dengue vector control and monitoring in Myanmar: Study protocol for a cluster randomized controlled trial
Authors: Overgaard Hans J. , Linn Nay Yi Yi , Kyaw Aye Mon Mon , Braack Leo , Win Tin Myo , Bastien Sheri , Vande Velde Fiona , Echaubard Pierre , Zaw Win , Mukaka Mavuto , Maude Richard 
Published: August 2022

Background. Dengue is the most common and widespread mosquito-borne arboviral disease globally estimated to cause >390 million infections and >20,000 deaths annually. There are no effective vaccines or preventive drugs. Control of dengue transmission relies primarily on mosquito vector control. Although most vector control methods currently used by national dengue control programs may temporarily reduce mosquito populations, there is little evidence that they affect transmission. There is an urgent need for innovative, participatory, effective, and locally adapted approaches for sustainable vector control and monitoring in which students can be particularly relevant contributors and to demonstrate a clear link between vector reduction and dengue transmission reduction, using tools that are inexpensive and easy to use by local communities in a sustainable manner. Methods. Here we describe a cluster randomized controlled trial to be conducted in 46 school catchment areas in two townships in Yangon, Myanmar. The outcome measures are dengue cases confirmed by rapid diagnostic test in the townships, dengue incidence in schools, entomological indices, knowledge, attitudes and practice, behavior, and engagement. Conclusions. The trial involves middle school students that positions them to become actors in dengue knowledge transfer to their communities and take a leadership role in the delivery of vector control interventions and monitoring methods. Following this rationale, we believe that students can become change agents of decentralized vector surveillance and sustainable disease control in line with recent new paradigms in integrated and participatory vector surveillance and control. This provides an opportunity to operationalize transdisciplinary research towards sustainable health development. Due to the COVID-19 pandemic and political instability in Myanmar the project has been terminated by the donor, but the protocol will be helpful for potential future implementation of the project in Myanmar and/or elsewhere. Registration: This trial was registered in the ISRCTN Registry on 31 May 2022 (https://doi.org/10.1186/ISRCTN78254298).
A Review on Energy-Sustainable Design and Operation of Greenhouses for Plant/Crop Production in Cold Regions
Authors: Wei Anni , Chen Yuxiang 
Published: August 2022

HighlightsIn cold regions, the immense energy consumption for space heating of greenhouses is a significant problem.Energy-efficient measures have been presented for conventional and nonconventional design aspects.Renewable resources have considerable potential to be used in greenhouses.Abstract. The energy consumption of greenhouses in cold regions, especially for space heating, is immense and therefore economically unbearable. The main objective of this article is to provide a comprehensive review of state-of-the-art energy-saving strategies for the design and operation of greenhouses in cold regions. The review covers conventional functions (lighting, air quality and temperature control, and irrigation), nonconventional functions (thermal insulation, thermal energy storage, and utilization of ground-source and renewable energy), and numerical modelling of the energy-performance of greenhouses. For each of these topics, pertinent plant science is provided and performance assessments are presented. The findings from this review conclude that hybrid lighting (LED with high-pressure sodium lamps) and proper scheduling result in the best combination of energy efficiency and plant yield. However, further studies are still required in this field. Keywords: Cold regions, Energy-efficiency, Greenhouse, Sustainability.
The Effects of Crosswind Speed on the Droplet Deposition Distribution of Thrush 510G Aircraft
Authors: Liu Qi , Lan Yubin , Wang Guobin , Zhu Hang , Chen Shengde 
Published: August 2022

HighlightsThe penetration ability of droplet in the crop canopy was in a negative correlation with wind speed.The high wind speed was conducive to the deposition of droplet on the crop canopy in the deposition area.The smaller the wind speed was, the more uniform the distribution of droplets became, and the worse the uniformity of droplet penetration.Abstract. Large plant protection fixed-wing aircrafts are widely used for crop spraying in Northeast China, because their working efficiency matches farm size. However, the spray droplet deposition and drift associated with manned fixed-wing aircraft has not been fully understood in China. The objectives of this study were to quantify effects of the small gradient crosswind speeds of 1.10, 0.83, and 0.58 m/s on the distribution and drift of droplets on soybean in the field. Water-sensitive paper (WSP) was used to collect the droplets on the upper canopy and lower parts of the plant. The results showed that the percentage of droplet deposition (the percentage of droplet deposition on the lower layer to that on the canopy of soybean plant) negatively correlated with the crosswind speeds. The crosswind speed had a significant influence on the deposition of droplets on the canopy and penetration performance. When the crosswind speed was 1.10 m/s, the deposition of droplet on the canopy was maximum and the average value of droplet penetration percentage was minimum, which was 6.11 µL and 50.6%, respectively. The average volume median diameters (VMD or DV0.5s) from all in-swath WSPs of three treatments were all smaller than that of droplet spectrum. The variation coefficients of droplet density in three treatments were 46.8%, 39.6%,and 34.1%, respectively, which indicated that the smaller the wind speed was, the more uniform the distribution of droplets became. The results revealed the influence of crosswind speed on the droplet distribution of large fixed-wing aircraft, which was of great significance to improve the operation. Keywords: Droplets distribution, Penetration, Uniformity performance, Wind speed.
Being a Vocational Teacher in Sweden: Navigating the Regime of Competence for Vocational Teachers
Authors: Antera Sofia 
Published: August 2022

Context: Vocational teachers are called to constantly meet the upcoming needs in social and working life. In Sweden, the high demand for vocational teachers has led to their recruitment in the early stages of vocational teacher studies or even before teacher training. Entering this new community of practice, vocational teachers cross boundaries between their previous occupation and their teaching job, mediating the introduction of competence between them. In this context, the study explores vocational teachers' competence through their own perceptions, addressing important competence areas, as well as how competence is understood. Approach: The study employs a socio-cultural perspective on learning. Communities of practice establish their regime of competence, a set of principles and expectations that recognise membership. To be competent is translated as understanding the shared enterprise of the community, being capable and allowed to engage in it and, thus, interact with the other members and with the available resources. Hence, what is expected by members to know and to be is defined by the regime of competence and, hence, by the community. Comprised of 14 semi-structured interviews with vocational teachers in different vocational disciplines, employed both in upper secondary and adult education schools, the study adopts a qualitative research strategy. The research material was analysed thematically. Findings: According to findings, important competence comprise of up-to-date vocational competence supporting the performance of vocational teaching, but also interpersonal competence, including good communication and the construction of a close relationship with the students. The student-teacher relationship serves as the basis to match students with their work placement, facilitating higher work-based training quality. Moreover, maintaining a continuous development attitude and openness to critique are crucial for teachers. Finally, teachers approach competence focusing on its relationship to action and performance, while also referring to its situated nature. Therefore, to be competent is understood differently in different practices (teaching and occupational), highlighting the importance of understanding the uniqueness and duality within the regime of competence of vocational teaching. Conclusion: Teachers have described the importance of competence which was not developed during teacher training. Instead, important competences were often developed in the previous profession or informal teaching activities. Vocational teachers seem to value and utilise their previous occupational worker identities to a high extent. This should be considered when teacher training or in-service training is designed to support individuals in developing their (new) teacher identity.
Design of a free-form off-axis three-mirror optical system with a low f-number based on the same substrate
Authors: Sun Yuanhe , Sun Yuanqi , Chen Xiaoyu , Wang Fang , Yan Xin , Zhang Xuenan , Cheng Tonglei 
Published: August 2022

In this paper, we design a free-form off-axis three-mirror optical system with a low

f

-number and compact structure, which can be used as an infrared reflection imager. The initial structure is calculated from the near-axis optical transfer matrix based on third-order aberration theory. Particular constraints are designed to install all mirrors on the same substrate for simultaneous milling, which reduces the processing difficulty and effectively avoids errors caused by component assembly. Zernike free-form surfaces are introduced to correct aberrations. This optical system has a field of view of

5

∘

×

5

∘

and an

f

-number of 1.82; the modulation transfer function of the system is higher than 0.6 at 30 lp/mm. The results of the tolerance assignment of the system were verified by the Monte Carlo method, and the machining tolerance is reasonable and easy to achieve. This design not only improves the optical performance of the system but also enhances the feasibility of manufacturing.
Income differences in COVID-19 incidence and severity in Finland among people with foreign and native background: A population-based cohort study of individuals nested within households
Authors: Saarinen Sanni , Moustgaard Heta , Remes Hanna , Sallinen Riikka , Martikainen Pekka 
Published: August 2022

Background
Although intrahousehold transmission is a key source of Coronavirus Disease 2019 (COVID-19) infections, studies to date have not analysed socioeconomic risk factors on the household level or household clustering of severe COVID-19. We quantify household income differences and household clustering of COVID-19 incidence and severity.

Methods and findings
We used register-based cohort data with individual-level linkage across various administrative registers for the total Finnish population living in working-age private households (N = 4,315,342). Incident COVID-19 cases (N = 38,467) were identified from the National Infectious Diseases Register from 1 July 2020 to 22 February 2021. Severe cases (N = 625) were defined as having at least 3 consecutive days of inpatient care with a COVID-19 diagnosis and identified from the Care Register for Health Care between 1 July 2020 and 31 December 2020. We used 2-level logistic regression with individuals nested within households to estimate COVID-19 incidence and case severity among those infected.
Adjusted for age, sex, and regional characteristics, the incidence of COVID-19 was higher (odds ratio [OR] 1.67, 95% CI 1.58 to 1.77, p < 0.001, 28.4% of infections) among individuals in the lowest household income quintile than among those in the highest quintile (18.9%). The difference attenuated (OR 1.23, 1.16 to 1.30, p < 0.001) when controlling for foreign background but not when controlling for other household-level risk factors. In fact, we found a clear income gradient in incidence only among people with foreign background but none among those with native background. The odds of severe illness among those infected were also higher in the lowest income quintile (OR 1.97, 1.52 to 2.56, p < 0.001, 28.0% versus 21.6% in the highest quintile), but this difference was fully attenuated (OR 1.08, 0.77 to 1.52, p = 0.64) when controlling for other individual-level risk factors—comorbidities, occupational status, and foreign background. Both incidence and severity were strongly clustered within households: Around 77% of the variation in incidence and 20% in severity were attributable to differences between households. The main limitation of our study was that the test uptake for COVID-19 may have differed between population subgroups.

Conclusions
Low household income appears to be a strong risk factor for both COVID-19 incidence and case severity, but the income differences are largely driven by having foreign background. The strong household clustering of incidence and severity highlights the importance of household context in the prevention and mitigation of COVID-19 outcomes.
Out of pocket payments and access to NCD medication in two regions in Albania
Authors: Gabrani Jonila , Schindler Christian , Wyss Kaspar 
Published: August 2022

Objective
The financial burden from noncommunicable diseases (NCDs) is a threat worldwide, alleviated only when good social protection schemes are in place. Albeit the Government in Albania has committed to Universal Healthcare Coverage (UHC), Out-of-Pockets (OOPs) persist. Through this study, we aimed to assess the OOPs related to consultations, diagnostic tests, and medicine prescriptions as self-reported by people suffering from NCDs.

Methods
A household survey was conducted in two regions of Albania. The present analysis includes respondents who suffered from chronic health conditions and consulted a health care provider within the last 8 weeks (n = 898). Mixed logistic regression models with random intercepts at the level of communities were employed in order to assess the association of OOPs with age, gender, urban vs. rural residency, health insurance, marital status, barriers experienced, type of chronic condition(s) and region.

Results
Of those who consulted a provider, 95% also received a drug prescription. Among them, 94% were able to obtain all the drugs prescribed. Out-of-pocket payments occurred throughout the NCD treatment process; specifically, for consultation (36%), diagnostic tests (33%), and drugs purchased (88%). Drug expenditures accounted for 62% of all household expenditures. Respondents with health insurance were less likely to pay for consultation and drugs. The elderly (patients above 60 years old) were less likely to pay for consultations and tests. Those who lived in urban areas were less likely to pay for drugs and consultations. Patients encountering any form of barrier when seeking care had increased odds of OOPs for consultations (OR; 2.25 95%-CI; 1.57; 3.23) and tests (OR; 1.71 95%-CI; 1.19; 2.45).

Conclusion
Out-of-pocket payments by NCD patients principally made up through the purchase of prescribed drugs, remain important. Tackling the high costs of drugs will be important to accelerate the UHC agenda. Here, it is important to raise the population’s awareness on patients’ knowledge of their entitlements to health insurance, and on the current health reforms.
Co-occurrence of non-communicable disease risk factors and its determinants among school-going adolescents of Kathmandu Metropolitan City
Authors: Tandon Kalpana , Adhikari Nabin , Adhikari Bikram , Pradhan Pranil Man Singh 
Published: August 2022

Background
Adolescence is a critical transition in human growth and adolescents tend to engage in various risky behaviors which are likely to continue into adulthood. Co-occurrence of non-communicable disease risk factors has the potential to increase risks of chronic disease comorbidity and increased mortality in later life. Behavioral risk factors are adopted due to changes in lifestyle and adolescents are more prone to acquire them. This study aimed to determine the prevalence and associated factors of co-occurrence of non-communicable disease risk factors among school-going adolescents of Kathmandu Metropolitan City.

Methods
We conducted a cross-sectional study among school-going adolescents of Kathmandu Metropolitan City in January/February 2020. We used stratified random sampling to select 1108 adolescents studying in 9, 10, 11, and 12 grades. We used Global Schools Health Survey tools to collect data. We entered data in EpiData 3.1 and exported it into Statistical Package for Social Science (SPSS) version 20 for statistical analysis. We estimated prevalence of NCDs risk factors and co-occurrence of risk factors. We applied multivariate multinomial logistic regression analysis adjusting for age, gender, ethnicity, religion, education, type of school, and parental education to determine factors associated with co-occurrence of NCDs risk factors.

Results
The prevalence of physical inactivity, unhealthy diet, harmful use of alcohol and tobacco among school-going adolescents were 72.3% (95%CI: 69.6–74.9), 41.1% (95%CI: 38.2–44.0), 14.8% (95%CI: 12.8–17.0) and 7.8% (95%CI:6.3–9.5) respectively. The adolescent with co-occurrence of two or more risk factors was 40.7% (95%CI: 37.8–43.7). The school-going adolescents who were in higher age group (AOR = 1.72, 95% CI- 1.06, 2.77), Hindus (AOR = 1.78, 95% CI-1.09, 2.89), other than Brahmin/Chhetri by ethnicity (AOR = 2.11, 95% CI-1.39, 2.22) and with lower education level of mothers (AOR = 2.40, 95% CI- 1.46,3.98) were more likely to have co-occurrence of NCDs risk factors after adjusting for all socio-demographic variables.

Conclusion
The co-occurrence of non-communicable disease risk factors was high among school going adolescents and was associated with age, religion, ethnicity and mother’s education. Integrated and comprehensive interventional programs should be developed by concerned authorities.
Falls in older patients: characteristics depending on functional status
Authors: Khovasova N. O. , Naumov A. V. , Tkacheva O. N. , Moroz V. I. 
Published: August 2022

Background: Falls and frailty are associated geriatric syndromes. Knowing the features of falls in patients with different functional status will make it possible to personalize the fall prevention and reduce the progression of frailty.Aim: To characterise falls in older depending on geriatric status (robust, prefrailty and frailty).Materials and methods: Included 1002 patients (77,5±8,2) hospitalized in the geriatric department. The frailty was screened on the scale «Age Not Interference». With the score 1–2, frailty was not diagnosed. With the score 3 or more, comprehensive geriatric assessment was carried out and 2 more groups were allocated: with prefrailty (n=199, 19.9%) and with frailty (n=482,48.1%). All patients found out the fact of falls during the year, if there was, they were characterized by falls. To analyze the effect of falls on functional status, it was evaluated in patients with frailty and falls and frailty without falls.Results: With increasing severity of geriatric status, the prevalence of falls increased, reaching 57% in patients with frailty. 63.7% previously noted falls, 44.7% formed a fear of falls. One in 10 falls resulted in a serious consequence, which caused hospitalization. The risk of falls increased depending on geriatric deficiency: patients with frailty at high risk were 2 times greater compared to robust patients. The findings demonstrate that patients with frailty undergoing falls compared to patients without falls.In patients with frailty and falls, compared to patients without falls, despite younger age and lower comorbidity, functional status was worse. They had a significantly lower score on the MNA, higher score on the PHQ-9 and anxiety score, and performed the chair stand longer. Multivariate analysis showed that a reduction in the sum of the SPPB by 0.35 and the PHQ-9 scale by 0.77, an increase in SARC-F by 0.68 and a time of performance of the chair stand by 3.39 seconds is associated with a fall in older people with frailty adjusted for age and comorbidity.Conclusion: Frailty is a conditionally reversible syndrome, and falls is often prevented. Considering the identified features of falls in patients with reduced functioning will allow individualizing the fall prevention plan.