bluuebunny/crossref_metadata_2025_split huggingface dataset:
2D image-based crack monitoring: an affordable, sufficient and non-invasive technique for the democratization of preventive conservation of listed buildings
Authors: Oliveros-Esco Jesús , Gracia-Villa Luis , López-Mesa Belinda 
Published: September 2022

Abstract
In order to democratize the preventive conservation of most listed buildings, we need to have an affordable tool that allows controlling their main vital signs. Complex and costly control installations, such as large digital data collection campaigns or 3D laser scanning, are not always possible. Methods for analogue data collection, such as comparators and callipers, are much more affordable and discreet but require the use of auxiliary lifting platforms for both installation and reading and control, hence resulting too invasive. In this paper we study techniques for digital indoor monitoring of cracks of listed masonry buildings. 2D image-based crack monitoring technique was found to be sufficient, affordable, traceable, and respectful with the use of the building. To verify its effectiveness, we performed laboratory tests and implement it in a real case study, a church in Zaragoza, Spain, currently undergoing a reparation process. The obtained results show that the proposed 2D image-based inspection technique provides measurements closer to the comparator, used as a reference, than the calliper, with a mean difference of 0.15 mm with respect to the reference, and a standard deviation of 0.17 mm, and its use can be up to 56% cheaper than the comparator. Therefore, the technique is easily generalizable to different heritage buildings.
The application of AI technologies in STEM education: a systematic review from 2011 to 2021
Authors: Xu Weiqi , Ouyang Fan 
Published: September 2022

Abstract
Background
The application of artificial intelligence (AI) in STEM education (AI-STEM), as an emerging field, is confronted with a challenge of integrating diverse AI techniques and complex educational elements to meet instructional and learning needs. To gain a comprehensive understanding of AI applications in STEM education, this study conducted a systematic review to examine 63 empirical AI-STEM research from 2011 to 2021, grounded upon a general system theory (GST) framework.

Results
The results examined the major elements in the AI-STEM system as well as the effects of AI in STEM education. Six categories of AI applications were summarized and the results further showed the distribution relationships of the AI categories with other elements (i.e., information, subject, medium, environment) in AI-STEM. Moreover, the review revealed the educational and technological effects of AI in STEM education.

Conclusions
The application of AI technology in STEM education is confronted with the challenge of integrating diverse AI techniques in the complex STEM educational system. Grounded upon a GST framework, this research reviewed the empirical AI-STEM studies from 2011 to 2021 and proposed educational, technological, and theoretical implications to apply AI techniques in STEM education. Overall, the potential of AI technology for enhancing STEM education is fertile ground to be further explored together with studies aimed at investigating the integration of technology and educational system.
Systematic review on the application of 3D-bioprinting technology in orthoregeneration: current achievements and open challenges
Authors: Pan Rachel L. , Martyniak Kari , Karimzadeh Makan , Gelikman David G. , DeVries Jonathan , Sutter Kelly , Coathup Melanie , Razavi Mehdi , Sawh-Martinez Rajendra , Kean Thomas J. 
Published: September 2022

AbstractBackgroundJoint degeneration and large or complex bone defects are a significant source of morbidity and diminished quality of life worldwide. There is an unmet need for a functional implant with near-native biomechanical properties. The potential for their generation using 3D bioprinting (3DBP)-based tissue engineering methods was assessed. We systematically reviewed the current state of 3DBP in orthoregeneration.MethodsThis review was performed using PubMed and Web of Science. Primary research articles reporting 3DBP of cartilage, bone, vasculature, and their osteochondral and vascular bone composites were considered. Full text English articles were analyzed.ResultsOver 1300 studies were retrieved, after removing duplicates, 1046 studies remained. After inclusion and exclusion criteria were applied, 114 articles were analyzed fully. Bioink material types and combinations were tallied. Cell types and testing methods were also analyzed. Nearly all papers determined the effect of 3DBP on cell survival. Bioink material physical characterization using gelation and rheology, and construct biomechanics were performed. In vitro testing methods assessed biochemistry, markers of extracellular matrix production and/or cell differentiation into respective lineages. In vivo proof-of-concept studies included full-thickness bone and joint defects as well as subcutaneous implantation in rodents followed by histological and µCT analyses to demonstrate implant growth and integration into surrounding native tissues.ConclusionsDespite its relative infancy, 3DBP is making an impact in joint and bone engineering. Several groups have demonstrated preclinical efficacy of mechanically robust constructs which integrate into articular joint defects in small animals. However, notable obstacles remain. Notably, researchers encountered pitfalls in scaling up constructs and establishing implant function and viability in long term animal models. Further, to translate from the laboratory to the clinic, standardized quality control metrics such as construct stiffness and graft integration metrics should be established with investigator consensus. While there is much work to be done, 3DBP implants have great potential to treat degenerative joint diseases and provide benefit to patients globally.
Antifungal activity of silver/silicon dioxide nanocomposite on the response of faba bean plants (Vicia faba L.) infected by Botrytis cinerea
Authors: Baka Zakaria A. , El-Zahed Mohamed M. 
Published: September 2022

AbstractSilicon (Si) and its nanomaterials could help plants cope with different negative effects of abiotic and/or biotic stresses. In this study, the antifungal role of silver/silicon dioxide nanocomposite (Ag/SiO2NC) biosynthesized using a free-cell supernatant ofEscherichia coliD8 was investigated for controlling the growth parameters and yield of faba bean (Vicia fabaL.) infected byBotrytis cinerea. This nanocomposite was characterized using UV–Vis spectroscopy, Fourier transform-infrared (FTIR), transmission electron microscopy (TEM), zeta analysis, and X-ray diffraction pattern (XRD). Positively charged Ag/SiO2NC (+ 31.0 mV) with spherical-shaped silver nanoparticles (AgNPs) showed strong in vitro antifungal activity with minimal inhibition concentration (MIC) value equal to 40 ppm. In vivo experiments revealed the good resistance of Ag/SiO2NC-treated plants against theB. cinereainfection due to the increase of total phenolic content, peroxidase, and polyphenol oxidase activity. The ultrastructure of Ag/SiO2NC-treated plants showed normal morphology of cells including cell membranes and ellipsoidal-shaped chloroplasts with big starch grains. The concentration of silver content in Ag/SiO2NC-treated plants was similar to the untreated control plant indicating the low realizability of AgNPs. All of these results are promising outcomes for the application of the biosynthesized Ag/SiO2NC as a safe and effective antifungal agent againstB. cinerea.Graphical Abstract
Comparative analysis of ECG records depending on body position in domestic swine (Sus scrofa domestica)
Authors: Kawicka Marta , Lewicki Maksymilian , Frydrychowski Piotr , Michałek Marcin , Noszczyk-Nowak Agnieszka 
Published: September 2022

Abstract
Background
Electrocardiography is a method widely applied in diagnosing abnormalities in the functioning of the heart muscle in veterinary medicine. It is a non-invasive and easy to perform test helpful in the general examination and a widely used patient monitoring method during anesthesia. Since the 1980s, pigs have become more and more popular companion animals. Moreover, the pig is a widely used model animal in biomedical research. Therefore, there is need to provide them with higher-quality veterinary services, also in emergency situations. It creates new challenges for veterinarians and the need to expand their knowledge of pigs’ treatment as pets. The aim of the planned experiment was to compare the ECG recordings made with two different body positions and determine if any differences occurred. Standard ECG in swine is performed under general anesthesia in the lying position on the left side, for this position of the body have been developed and reported standards in the literature. However, some procedures performed on swine require a different body position, for which there is less data in the literature.

Methods
The study was carried out on 29 Polish landrace pigs weighing in the range of 33–44 kg. The tests were performed under general anesthesia with the same protocol for each animal, placing the animals first lying down on their right side, and then on their backs. The anesthesia protocol included medetomidine, midazolam, ketamine, and propofol. During the examination, ECG records were performed and analyzed in a 12-lead system with software support.

Results
The results show significant differences in electrocardiogram recordings depending on the animal's body position. Those differences mainly concern the amplitude of the P wave and R wave in the recordings and are even more visible comparing the electrocardiograms of the same specimen. There are also some significant differences in the duration of intervals. Based on the obtained results, reference ranges for the right lateral and dorsal positions were developed.

Conclusion
In conclusion, the body position has a significant impact on the ECG recording in swine, therefore performing this examination, chosen normative value tables should be compatible with the position of the examined animal.
Functional, imaging, and respiratory evaluation (FIRE) of patients post-hospitalization for COVID-19: protocol for a pilot observational study
Authors: Mayer Kirby P. , Palakshappa Jessica A. , Peltan Ithan Daniel , Andrew James S. , Gundel Stephanie J. , Ringwood Nancy J. , Mckeehan Jeffrey , Hope Aluko A. , Rogers Angela J. , Biehl Michelle , Hayden Douglas L. , Caldwell Ellen , Mehkri Omar , Lynch David J. , Burham Ellen L. , Hough Catherine L. , Jolley Sarah E. ,   for the NHLBI PETAL Network
Published: September 2022

Abstract
Introduction
We describe a protocol for FIRE CORAL, an observational cohort study that examines the recovery from COVID-19 disease following acute hospitalization with an emphasis on functional, imaging, and respiratory evaluation.

Methods and analysis
FIRE CORAL is a multicenter prospective cohort study of participants recovering from COVID-19 disease with in-person follow-up for functional and pulmonary phenotyping conducted by the National Heart, Lung and Blood Institute (NHLBI) Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. FIRE CORAL will include a subset of participants enrolled in Biology and Longitudinal Epidemiology of PETAL COVID-19 Observational Study (BLUE CORAL), an NHLBI-funded prospective cohort study describing the clinical characteristics, treatments, biology, and outcomes of hospitalized patients with COVID-19 across the PETAL Network. FIRE CORAL consists of a battery of in-person assessments objectively measuring pulmonary function, abnormalities on lung imaging, physical functional status, and biospecimen analyses. Participants will attend and perform initial in-person testing at 3 to 9 months after hospitalization. The primary objective of the study is to determine the feasibility of longitudinal assessments investigating multiple domains of recovery from COVID-19. Secondarily, we will perform descriptive statistics, including the prevalence and characterization of abnormalities on pulmonary function, chest imaging, and functional status. We will also identify potential clinical and biologic factors that predict recovery or the occurrence of persistent impairment of pulmonary function, chest imaging, and functional status.

Ethics and dissemination
FIRE CORAL is approved via the Vanderbilt University central institutional review board (IRB) and via reliance agreement with the site IRBs. Results will be disseminated via the writing group for the protocol committee and reviewed by the PETAL Network publications committee prior to publication. Data obtained via the study will subsequently be made publicly available via NHLBI’s biorepository.

Strengths and limitations of the study
Strengths:

First US-based multicenter cohort of pulmonary and functional outcomes in patients previously hospitalized for COVID-19 infection

Longitudinal biospecimen measurement allowing for biologic phenotyping of abnormalities

Geographically diverse cohort allowing for a more generalizable understanding of post-COVID pulmonary sequela

Limitations:

Selected cohort given proximity to a participating center

Small cohort which may be underpowered to identify small changes in pulmonary function
An overview of Fintech applications to solve the puzzle of health care funding: state-of-the-art in medical crowdfunding
Authors: Grassi Laura , Fantaccini Simone 
Published: September 2022

AbstractCrowdfunding is emerging as an alternative form of funding for medical purposes, with capital being raised directly from a broader and more diverse audience of investors. In this paper, we have systematically researched and reviewed the literature on medical crowdfunding to determine how crowdfunding connects with the health care industry. The health care industry has been struggling to develop sustainable research and business models for economic systems and investors alike, especially in pharmaceuticals. The research results have revealed a wealth of evidence concerning the way crowdfunding is applied in real life. Patients and caregivers utilize web platform–based campaigns all over the world to fund their medical expenses, generally on a spot basis, using donation-based or even reward-based schemes, regardless of the health care system archetype (public, private insurance-based or hybrid). Academics have also focused on funding campaigns and the predictors of success (which range from social behaviour and environment to the basic demographics of the campaigners and their diseases) and on social and regulatory concerns, including heightened social inequality and stigma. While equity crowdfunding is disrupting the way many ventures/businesses seek capital in the market, our research indicates that there are no relevant or consistent data on the practice of medical equity crowdfunding in health care, apart from a few anecdotal cases.
Developing an online learner satisfaction framework in higher education through a systematic review of research
Authors: Martin Florence , Bolliger Doris U. 
Published: September 2022

AbstractSatisfaction is a critical aspect of student success in online education. In this systematic review, we examine 98 articles which studied various aspects of online learner satisfaction. We specifically analyzed publication patterns, context, research methodology, research instruments, and research themes and factors pertaining to online learner satisfaction research. Among these 98 studies, the journal Internet and Higher Education published the highest number of articles (n = 8), and the majority of studies were conducted in the United States (n = 37). Thirty five percent of the studies were conducted with undergraduate students. The majority of the studies (89%) was quantitative, 68% were descriptive, and 94% used surveys. Learner characteristics was the most examined theme, followed by engagement and course delivery. Program quality, assessment, and learner support were some of the themes that were least studied. In 46 studies researchers adopted or modified existing items or instruments to measure student satisfaction. The framework benefits both online learning practitioners and researchers.
Introductory evidence on data management and practice systems of forensic autopsies in sudden and unnatural deaths: a scoping review
Authors: Prahladh Salona , van Wyk Jacqueline 
Published: September 2022

Abstract
Background
The investigation into sudden unexpected and unnatural deaths supports criminal justice, aids in litigation, and provides important information for public health including surveillance, epidemiology, and prevention programs. The use of mortality data to convey trends can inform policy development and resource allocations. Hence, data practices/management systems in Forensic Medicine are critical. This study scoped literature and described the body of knowledge on data management and practice systems in Forensic Medicine.

Methods
Five steps of the methodological framework of Arksey and O’Malley guided this scoping review. A combination of keywords, Boolean terms, and Medical Subject Headings was used to search PubMed, EBSCOhost (CINAHL with full text and Health Sources), Cochrane Library, Scopus, Web of Science, Science Direct, WorldCat, and Google Scholar from the 18th to 24th of June 2020 and updated in November 2021 for peer review papers. This study included articles involving unnatural deaths, focused on data practice or data management systems, relating to Forensic Medicine, all study designs, and published in English. Screening and selection and data extraction were conducted by two reviews. Thematic analysis was conducted, and the results were reported using both quantitatively and qualitatively.

Results
Of the 23,059 articles, 16 met this study’s inclusion criteria. The included articles were published between 2008 and 2019. Eight of the 16 articles were published between 2017 and 2019. Most of the included studies were conducted in the USA (5) and Australia/New Zealand (4). Only two publications were from lower- and middle-income countries (Nigeria, Mexico), and the remaining 14 were from high-income countries (Italy, Denmark, USA, Australia, and New Zealand, Japan, Switzerland, Canada). The data management systems found in this study were as follows: Virtopsy, Canadian Coroner and Medical Examiner Database, Infant Injury Database, Fatal injury surveillance system, Medical Examiners and Coroners Alert System, National Violent Deaths Reporting System, AM/PM Database, Tokyo CDISC/ODM, and National Coronial Information System.

Conclusions
This study’s results revealed limited articles relating to data management and practice systems in Forensic Medicine, particularly in LMICs through literature indicating there is a prevalence of unnatural deaths in LMICs. This study, therefore, recommends research on data management and practice systems relating to forensic medicine in LMICs to inform policy decisions.
The diagnostic dilemma of congenital foot deformity in pediatrics: could adding ultrasound be problem solving?
Authors: Kamel Sara Mahmoud , Arafa Amr Said , Labeb Germeen Wagih , Abdelrahman Sherif Fathy 
Published: September 2022

Abstract
Background
Foot deformity is one of the most common congenital musculoskeletal anomalies in the pediatric age group. Accurate diagnosis can be sometimes impossible to be established clinically. In the assessment of foot abnormalities, radiology plays a crucial role. Lack of ossification of the tarsal bones renders plain radiographs of the foot as of little diagnostic value in this age group. MRI apart from its cost requires anesthesia and sedation. In contrast, ultrasonography allows for the imaging of cartilaginous structures. As a result, newborn foot abnormalities can be thoroughly assessed. The whole anatomy of the foot is evaluated using several scanning views. Additional planes may be needed to show the pathologic features of a specific deformity. The purpose of this study was to demonstrate the additive value of ultrasound to plain radiographs in the assessment of foot deformities in the pediatric age group.

Results
This case–control study was performed on sixty children, 30 of which were patients admitted from the pediatric orthopedic clinic, presenting with foot deformity, after being examined clinically. Antero-posterior and lateral radiographs of foot, tibiocalcaneal, antero-posterior talocalcaneal, and lateral talocalcaneal angles were measured. Sonographic examination was done in different projections of both feet, while the patient is lying supine with dynamic sonography. The sonographic parameters measured were as follows: medial malleolar–navicular distance and medial soft tissue thickness on medial projection, calcaneocuboid distance on lateral projection, talonavicular relation on dorsal projection, and tibiocalcaneal distance on posterior projection. There was a statistically significant difference between patients and controls in the medial malleolar–navicular distance and medial soft tissue thickness measured on the medial view, the calcaneocuboid distance recorded on the lateral view, and the tibiocalcaneal distance measured on the posterior view.

Conclusions
Ultrasonography has a growing and useful role as a complementary imaging modality in the evaluation and follow-up of pediatric patients with foot deformity.
Sinusoidal Organic Anion-Transporting Polypeptide 1B1/1B3 and Bile Canalicular Multidrug Resistance-Associated Protein 2 Play an Essential Role in the Hepatobiliary Disposition of a Synthetic Cyclic Dinucleotide (STING Agonist)
Authors: Sandoval Philip , Chuang Bei-Ching , Fallon John K. , Smith Philip C. , Chowdhury Swapan K. , Griffin Robert J. , Xia Cindy Q. , Iwasaki Shinji , Chothe Paresh P. 
Published: September 2022

AbstractThe liver is central to the elimination of many drugs from the body involving multiple processes and understanding of these processes is important to quantitively assess hepatic clearance of drugs. The synthetic STING (STimulator of INterferon Genes protein) agonist is a new class of drugs currently being evaluated in clinical trials as a potential anticancer therapy. In this study, we used ML00960317 (synthetic STING agonist) to investigate the hepatobiliary disposition of this novel molecular entity. A bile-duct cannulated (BDC) rat study indicated that biliary excretion is the major route of elimination for ML00960317 (84% of parent dose in bile). The human biliary clearance using in vitro sandwich cultured human hepatocyte model predicted significant biliary excretion of ML00960317 (biliary excretion index (BEI) of 47%). Moreover, the transport studies using transporter expressing cell lines, hepatocytes, and membrane vesicles indicated that ML00960317 is a robust substrate of OATP1B1, OATP1B3, and MRP2. Using relative expression factor approach, the combined contribution of OATP1B1 (fraction transported (ft) = 0.62) and OATP1B3 (ft = 0.31) was found to be 93% of the active uptake clearance of ML00960317 into the liver. Furthermore, OATP1B1 and OATP1B3-mediated uptake of ML00960317 was inhibited by rifampicin with IC50 of 6.5 and 2.3 μM, respectively indicating an in vivo DDI risk (R value of 1.5 and 2.5 for OATP1B1 and OATP1B3, respectively). These results highlighted an important role of OATP1B1, OATP1B3, and MRP2 in the hepatobiliary disposition of ML00960317. These pathways may act as rate-determining steps in the hepatic clearance of ML00960317 thus presenting clinical DDI risk.
Graphical Abstract