bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new strategy to minimize humidity influences on acoustic wave ultraviolet sensors using ZnO nanowires wrapped with hydrophobic silica nanoparticles
Authors: Guo Yihao , Zhou Jian , Ji Zhangbin , Liu Yanghui , Cao Rongtao , Zhuo Fengling , Tan Kaitao , Duan Huigao , Fu Yongqing 
Published: November 2022

AbstractSurface acoustic wave (SAW) technology has been widely developed for ultraviolet (UV) detection due to its advantages of miniaturization, portability, potential to be integrated with microelectronics, and passive/wireless capabilities. To enhance UV sensitivity, nanowires (NWs), such as ZnO, are often applied to enhance SAW-based UV detection due to their highly porous and interconnected 3D network structures and good UV sensitivity. However, ZnO NWs are normally hydrophilic, and thus, changes in environmental parameters such as humidity will significantly influence the detection precision and sensitivity of SAW-based UV sensors. To solve this issue, in this work, we proposed a new strategy using ZnO NWs wrapped with hydrophobic silica nanoparticles as the effective sensing layer. Analysis of the distribution and chemical bonds of these hydrophobic silica nanoparticles showed that numerous C-F bonds (which are hydrophobic) were found on the surface of the sensitive layer, which effectively blocked the adsorption of water molecules onto the ZnO NWs. This new sensing layer design minimizes the influence of humidity on the ZnO NW-based UV sensor within the relative humidity range of 10–70%. The sensor showed a UV sensitivity of 9.53 ppm (mW/cm2)−1, with high linearity (R2value of 0.99904), small hysteresis (<1.65%) and good repeatability. This work solves the long-term dilemma of ZnO NW-based sensors, which are often sensitive to humidity changes.
Emergence of changing Central-Pacific and Eastern-Pacific El Niño-Southern Oscillation in a warming climate
Authors: Geng Tao , Cai Wenju , Wu Lixin , Santoso Agus , Wang Guojian , Jing Zhao , Gan Bolan , Yang Yun , Li Shujun , Wang Shengpeng , Chen Zhaohui , McPhaden Michael J. 
Published: November 2022

AbstractEl Niño-Southern Oscillation (ENSO) features strong warm events in the eastern equatorial Pacific (EP), or mild warm and strong cold events in the central Pacific (CP), with distinct impacts on global climates. Under transient greenhouse warming, models project increased sea surface temperature (SST) variability of both ENSO regimes, but the timing of emergence out of internal variability remains unknown for either regime. Here we find increased EP-ENSO SST variability emerging by around 2030 ± 6, more than a decade earlier than that of CP-ENSO, and approximately four decades earlier than that previously suggested without separating the two regimes. The earlier EP-ENSO emergence results from a stronger increase in EP-ENSO rainfall response, which boosts the signal of increased SST variability, and is enhanced by ENSO non-linear atmospheric feedback. Thus, increased ENSO SST variability under greenhouse warming is likely to emerge first in the eastern than central Pacific, and decades earlier than previously anticipated.
Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination
Authors: de Koff Emma M. , van Baarle Debbie , van Houten Marlies A. , Reyman Marta , Berbers Guy A. M. , van den Ham Femke , Chu Mei Ling J. N. , Sanders Elisabeth A. M. , Bogaert Debby , Fuentes Susana 
Published: November 2022

AbstractThe gut microbiota in early life, when critical immune maturation takes place, may influence the immunogenicity of childhood vaccinations. Here we assess the association between mode of delivery, gut microbiota development in the first year of life, and mucosal antigen-specific antibody responses against pneumococcal vaccination in 101 infants at age 12 months and against meningococcal vaccination in 66 infants at age 18 months. Birth by vaginal delivery is associated with higher antibody responses against both vaccines. Relative abundances of vaginal birth-associated Bifidobacterium and Escherichia coli in the first weeks of life are positively associated with anti-pneumococcal antibody responses, and relative abundance of E. coli in the same period is also positively associated with anti-meningococcal antibody responses. In this study, we show that mode of delivery-induced microbiota profiles of the gut are associated with subsequent antibody responses to routine childhood vaccines.
Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice
Authors: Ashhurst Anneliese S. , Johansen Matt D. , Maxwell Joshua W. C. , Stockdale Skye , Ashley Caroline L. , Aggarwal Anupriya , Siddiquee Rezwan , Miemczyk Stefan , Nguyen Duc H. , Mackay Joel P. , Counoupas Claudio , Byrne Scott N. , Turville Stuart , Steain Megan , Triccas James A. , Hansbro Philip M. , Payne Richard J. , Britton Warwick J. 
Published: November 2022

AbstractCurrent vaccines against SARS-CoV-2 substantially reduce mortality, but protection against infection is less effective. Enhancing immunity in the respiratory tract, via mucosal vaccination, may provide protection against infection and minimise viral spread. Here, we report testing of a subunit vaccine in mice, consisting of SARS-CoV-2 Spike protein with a TLR2-stimulating adjuvant (Pam2Cys), delivered to mice parenterally or mucosally. Both routes of vaccination induce substantial neutralising antibody (nAb) titres, however, mucosal vaccination uniquely generates anti-Spike IgA, increases nAb in the serum and airways, and increases lung CD4+ T-cell responses. TLR2 is expressed by respiratory epithelia and immune cells. Using TLR2 deficient chimeric mice, we determine that TLR2 expression in either compartment facilitates early innate responses to mucosal vaccination. By contrast, TLR2 on hematopoietic cells is essential for optimal lung-localised, antigen-specific responses. In K18-hACE2 mice, vaccination provides complete protection against disease and sterilising lung immunity against SARS-CoV-2, with a short-term non-specific protective effect from mucosal Pam2Cys alone. These data support mucosal vaccination as a strategy to improve protection in the respiratory tract against SARS-CoV-2 and other respiratory viruses.
Cycles of Andean mountain building archived in the Amazon Fan
Authors: Mason Cody C. , Romans Brian W. , Patterson Molly O. , Stockli Daniel F. , Fildani Andrea 
Published: November 2022

AbstractCordilleran orogenic systems have complex, polycyclic magmatic and deformation histories, and the timescales and mechanisms of episodic orogenesis are still debated. Here, we show that detrital zircons (DZs) in terrigenous sediment from the late Pleistocene Amazon Fan, found at the terminus of the continent-scale Amazon River-fan system, record multiple, distinct modes of U-Pb crystallization ages and U-Th/He (ZHe) cooling ages that correlate to known South American magmatic and tectonic events. The youngest ZHe ages delineate two recent phases of Andean orogenesis; one in the Late Cretaceous – Paleogene, and another in the Miocene. Frequency analyses of the deep-time Phanerozoic record of DZ U-Pb and ZHe ages demonstrate a strong 72 Myr period in magmatic events, and 92 Myr and 57 Myr periods in crustal cooling. We interpret these results as evidence of changes in upper and lower plate coupling, associated with multiple episodes of magmatism and crustal deformation along the subduction-dominated western margin of South America.
Structure of the reduced microsporidian proteasome bound by PI31-like peptides in dormant spores
Authors: Jespersen Nathan , Ehrenbolger Kai , Winiger Rahel R. , Svedberg Dennis , Vossbrinck Charles R. , Barandun Jonas 
Published: November 2022

AbstractProteasomes play an essential role in the life cycle of intracellular pathogens with extracellular stages by ensuring proteostasis in environments with limited resources. In microsporidia, divergent parasites with extraordinarily streamlined genomes, the proteasome complexity and structure are unknown, which limits our understanding of how these unique pathogens adapt and compact essential eukaryotic complexes. We present cryo-electron microscopy structures of the microsporidian 20S and 26S proteasome isolated from dormant or germinated Vairimorpha necatrix spores. The discovery of PI31-like peptides, known to inhibit proteasome activity, bound simultaneously to all six active sites within the central cavity of the dormant spore proteasome, suggests reduced activity in the environmental stage. In contrast, the absence of the PI31-like peptides and the existence of 26S particles post-germination in the presence of ATP indicates that proteasomes are reactivated in nutrient-rich conditions. Structural and phylogenetic analyses reveal that microsporidian proteasomes have undergone extensive reductive evolution, lost at least two regulatory proteins, and compacted nearly every subunit. The highly derived structure of the microsporidian proteasome, and the minimized version of PI31 presented here, reinforce the feasibility of the development of specific inhibitors and provide insight into the unique evolution and biology of these medically and economically important pathogens.
Lithium hexamethyldisilazide as electrolyte additive for efficient cycling of high-voltage non-aqueous lithium metal batteries
Authors: Zhang Danfeng , Liu Ming , Ma Jiabin , Yang Ke , Chen Zhen , Li Kaikai , Zhang Chen , Wei Yinping , Zhou Min , Wang Peng , He Yuanbiao , Lv Wei , Yang Quan-Hong , Kang Feiyu , He Yan-Bing 
Published: November 2022

AbstractHigh-voltage lithium metal batteries suffer from poor cycling stability caused by the detrimental effect on the cathode of the water moisture present in the non-aqueous liquid electrolyte solution, especially at high operating temperatures (e.g., ≥60 °C). To circumvent this issue, here we report lithium hexamethyldisilazide (LiHMDS) as an electrolyte additive. We demonstrate that the addition of a 0.6 wt% of LiHMDS in a typical fluorine-containing carbonate-based non-aqueous electrolyte solution enables a stable Li||LiNi0.8Co0.1Mn0.1O2 (NCM811) coin cell operation up to 1000 or 500 cycles applying a high cut-off cell voltage of 4.5 V in the 25 °C−60 °C temperature range. The LiHMDS acts as a scavenger for hydrofluoric acid and water and facilitates the formation of an (electro)chemical robust cathode|electrolyte interphase (CEI). The LiHMDS-derived CEI prevents the Ni dissolution of NCM811, mitigates the irreversible phase transformation from layered structure to rock-salt phase and suppresses the side reactions with the electrolyte solution.
Anti-Ad26 humoral immunity does not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination
Authors: Byazrova Maria G. , Astakhova Ekaterina A. , Minnegalieva Aygul R. , Sukhova Maria M. , Mikhailov Artem A. , Prilipov Alexey G. , Gorchakov Andrey A. , Filatov Alexander V. 
Published: November 2022

AbstractReplication-incompetent adenoviral vectors have been extensively used as a platform for vaccine design, with at least four anti-COVID-19 vaccines authorized to date. These vaccines elicit neutralizing antibody responses directed against SARS-CoV-2 Spike protein and confer significant level of protection against SARS-CoV-2 infection. Immunization with adenovirus-vectored vaccines is known to be accompanied by the production of anti-vector antibodies, which may translate into reduced efficacy of booster or repeated rounds of revaccination. Here, we used blood samples from patients who received an adenovirus-based Gam-COVID-Vac vaccine to address the question of whether anti-vector antibodies may influence the magnitude of SARS-CoV-2-specific humoral response after booster vaccination. We observed that rAd26-based prime vaccination with Gam-COVID-Vac induced the development of Ad26-neutralizing antibodies, which persisted in circulation for at least 9 months. Our analysis further indicates that high pre-boost Ad26 neutralizing antibody titers do not appear to affect the humoral immunogenicity of the Gam-COVID-Vac boost. The titers of anti-SARS-CoV-2 RBD IgGs and antibodies, which neutralized both the wild type and the circulating variants of concern of SARS-CoV-2 such as Delta and Omicron, were independent of the pre-boost levels of Ad26-neutralizing antibodies. Thus, our results support the development of repeated immunization schedule with adenovirus-based COVID-19 vaccines.
Synthetic control of the surface area in nickel cobalt oxide for glucose detection via additive-assisted wet chemical method
Authors: Jang Kyu-bong , Park Kyoung Ryeol , Mo Chan Bin , Kim Seongtak , Jeon Jaeeun , Lim Sung-chul , Ahn Chisung , Han HyukSu , Kim Dongju , Lee Seung Hwan , Kim Kang Min , Mhin Sungwook 
Published: November 2022

AbstractWe investigated the effect of specific surface area on the electrochemical properties of NiCo2O4 (NCO) for glucose detection. NCO nanomaterials with controlled specific surface areas were prepared by additive-assisted hydrothermal synthesis, and self-assembled nanostructures with urchin-, pine-needle-, tremella-, and flower-like morphologies were obtained. The novelty of this method is the systematic control of chemical reaction routes assisted by the addition of different additives during synthesis, which results in the spontaneous formation of various morphologies without any difference in the crystal structure and chemical states of the constituent elements. Such morphological control of NCO nanomaterials leads to considerable changes in the electrochemical performance for glucose detection. Combined with materials characterization, the relationship between the specific surface area and the electrochemical performance is discussed for glucose detection. This work can provide scientific insights for tailoring the surface area of nanostructures, which determines their functionality for potential applications in glucose biosensors.
Lithology and disturbance drive cavefish and cave crayfish occurrence in the Ozark Highlands ecoregion
Authors: Mouser Joshua B. , Brewer Shannon K. , Niemiller Matthew L. , Mollenhauer Robert , Van Den Bussche Ronald A. 
Published: November 2022

AbstractDiverse communities of groundwater-dwelling organisms (i.e., stygobionts) are important for human wellbeing; however, we lack an understanding of the factors driving their distributions, making it difficult to protect many at-risk species. Therefore, our study objective was to determine the landscape factors related to the occurrence of cavefishes and cave crayfishes in the Ozark Highlands ecoregion, USA. We sampled cavefishes and cave crayfishes at 61 sampling units using both visual and environmental DNA surveys. We then modeled occurrence probability in relation to lithology and human disturbance while accounting for imperfect detection. Our results indicated that occurrence probability of cave crayfishes was negatively associated with human disturbance, whereas there was a weak positive relationship between cavefish occurrence and disturbance. Both cavefishes and cave crayfishes were more likely to occur in limestone rather than dolostone lithology. Our results indicate structuring factors are related to the distribution of these taxa, but with human disturbance as a prevalent modifier of distributions for cave crayfishes. Limiting human alteration near karst features may be warranted to promote the persistence of some stygobionts. Moreover, our results indicate current sampling efforts are inadequate to detect cryptic species; therefore, expanding sampling may be needed to develop effective conservation actions.
Mutagenesis alters sperm swimming velocity in Astyanax cave fish
Authors: Borowsky Richard , Chen Haining 
Published: November 2022

AbstractWe investigated the hypothesis that intra ejaculate sperm competition screens against the transmission of deleterious alleles, including new mutants, from male parent to offspring. Recent investigations have established that sperm haploid genotypes can have major effects on sperm traits such as cellular robustness, longevity, and fertilization success. However, there is no evidence that new mutations can meaningfully affect sperm phenotypes. We tested this directly by comparing sperm from mutagenized and non-mutagenized control males in Astyanax fish. We used N-ethyl-N-nitrosourea (ENU) to induce single base substitutions in spermatogonial stem cells. We looked at swimming velocity, an important factor contributing to fertilization success, and flagellar length. Variability in swimming velocity was significantly higher in sperm from mutagenized males than in control sperm, reflecting their increased allelic diversity. In contrast, flagellar length, which is fixed during diploid stages of spermatogenesis, was unaffected by ENU treatment. We briefly discuss the implications of intra-ejaculate screening for maintenance of anisogamy and for outcomes of assisted reproductive technology.
Longitudinal impact of COVID-19 pandemic on mental health of children in the ABCD study cohort
Authors: Hamatani Sayo , Hiraoka Daiki , Makita Kai , Tomoda Akemi , Mizuno Yoshifumi 
Published: November 2022

AbstractA large longitudinal study on the impact of the COVID-19 pandemic on mental health in children is limited. This large-scale longitudinal observational study examines the pandemic’s effects on children’s mental health while considering the effects of parental care styles. The Adolescent Brain Cognitive Development Study is a large-scale, longitudinal multicenter study in the United States. Of the 11,875 children aged 9–12 years in its database, 4702 subjects were selected for this study. The child behavior checklist and parental monitoring questionnaire (PMQ) were used to assess children’s mental health and parental support styles, respectively. Data collected before and during the pandemic were compared. Withdrawn/depressed and attention problems significantly worsened during compared to before the COVID-19 pandemic (p < 0.001, withdrawn/depressed; 53.4 ± 5.7 to 53.7 ± 5.9, attention problems; 53.4 ± 5.4 to 53.6 ± 5.6). However, the T scores are in the normal range both before and during the crisis. Simple slope analysis found withdrawn/depressed problems and aggressive behavior worsened when the PMQ was 1 SD below the mean, and rule-breaking behavior was improved when the PMQ was 1 SD above the mean. While the COVID-19 pandemic exacerbated children’s depressive symptoms and attention issues, the effects may be minor. Additionally, parental involvement serve as a protective factor for the child’s mental health even during the pandemic.
Restricted cafeteria feeding and treadmill exercise improved body composition, metabolic profile and exploratory behavior in obese male rats
Authors: Alvarez-Monell Adam , Subias-Gusils Alex , Mariné-Casadó Roger , Belda Xavier , Gagliano Humberto , Pozo Oscar J. , Boqué Noemí , Caimari Antoni , Armario Antonio , Solanas Montserrat , Escorihuela Rosa M. 
Published: November 2022

AbstractThe aim of this study was to evaluate, in male Long-Evans rats, whether a restricted-cafeteria diet (CAFR), based on a 30% calorie restriction vs continuous ad libitum cafeteria (CAF) fed animals, administered alone or in combination with moderate treadmill exercise (12 m/min, 35 min, 5 days/week for 8 weeks), was able to ameliorate obesity and the associated risk factors induced by CAF feeding for 18 weeks and to examine the changes in circadian locomotor activity, hypothalamic–pituitary–adrenal (HPA) axis functionality, and stress response elicited by this dietary pattern. In addition to the expected increase in body weight and adiposity, and the development of metabolic dysregulations compatible with Metabolic Syndrome, CAF intake resulted in a sedentary profile assessed by the home-cage activity test, reduced baseline HPA axis activity through decreased corticosterone levels, and boosted exploratory behavior. Both CAFR alone and in combination with exercise reduced abdominal adiposity and hypercholesterolemia compared to CAF. Exercise increased baseline locomotor activity in the home-cage in all dietary groups, boosted exploratory behavior in STD and CAF, partially decreased anxiety-like behavior in CAF and CAFR, but did not affect HPA axis-related parameters.
The placebo effect shortens movement time in goal-directed movements
Authors: Fiorio Mirta , Villa-Sánchez Bernardo , Rossignati Filippo , Emadi Andani Mehran 
Published: November 2022

AbstractThe placebo effect is a powerful psychobiological phenomenon whereby a positive outcome follows the administration of an inert treatment thought to be effective. Growing evidence shows that the placebo effect extends beyond the healing context, affecting also motor performance. Here we explored the placebo effect on the control of goal-directed movement, a fundamental function in many daily activities. Twenty-four healthy volunteers performed upper-limb movements toward a target at different indexes of difficulty in two conditions: in the placebo condition, an electrical device (inert) was applied to the right forearm together with verbal information about its positive effects in improving movement precision; in the control condition, the same device was applied along with verbal information about its neutral effects on performance. Interestingly, we found shorter movement time in the placebo compared to the control condition. Moreover, subjective perception of fatigability was reduced in the placebo compared to the control condition. These findings indicate that the placebo effect can improve the execution of goal-directed movements, thus adding new evidence to the placebo effect in the motor domain. This study could inspire future applications to improve upper-limb movements or in clinical settings for patients with motor deficits.
Protective effect of Tisochrysis lutea on dry eye syndrome via NF-κB inhibition
Authors: Hong Sung-Chul , Yu Hyung Seok , Kim Jin-Woo , Lee Eun Ha , Pan Cheol-Ho , Hong Kwang Won , Kim Jin-Chul 
Published: November 2022

AbstractDry eye syndrome (DES) affects the cornea, causes pain and hypersensitivity to light. Although inflammation and endoplasmic reticulum stress are known to be involved, the detailed mechanisms remain unknown. DES is characterized by a decrease in corneal thickness, tear volume, and lacrimal gland size, and damage to corneal cells. Tisochrysis lutea is a microalga that has been shown to reduce immune factors. Therefore, we hypothesized that T. lutea could ameliorate DES. We investigated the role of T. lutea in scopolamine-induced DES in BALB/c mice. Oral administration of T. lutea increased corneal thickness, tear volume, and size of the corneal cells, and reduced damage to the corneal cells. Furthermore, treatment of ARPE-19 human retinal pigmented epithelial cells with T. lutea reduced expression of the inflammatory factor, NF-κB, MAPK, and AKT. T. lutea may be used therapeutically to reduce the symptoms of DES.