bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel CineECG to identify disease onset and progression in pathogenic plakophilin-2 mutation carriers
Authors: Boonstra MJ , Kloosterman M , Asselbergs FW , Van Dam PM , Loh P 
Published: May 2022

Abstract

Funding Acknowledgements
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Dutch Heart Foundation

Introduction
Arrhythmogenic cardiomyopathy (ACM) is a heterogeneous progressive disease. Identification of patients at risk for malignant ventricular arrhythmias is challenging, making extensive cardiac follow-up necessary. CineECG provides insight in the average cardiac pathway of cardiac electrical activity. In previous studies, CineECG proved useful to detect disease progression.

Objective
Evaluate the applicability of CineECG to monitor disease progression in plakophilin-2 (PKP2) pathogenic mutation carriers.

Methods
To compute the CineECG, a 3D heart/torso model and 12 lead ECG is used. From 68 PKP2 pathogenic mutation carriers, all raw ECGs were extracted from the patient database. In pathogenic mutation carriers with definite ACM, the ECG ±2 years before (ECG1), at (ECG2) and ±2 years after (ECG3) diagnosis were selected. In pathogenic mutation carriers without definite ACM, the most recent ECG (ECG2) and the ECG ±2 years before (ECG1) were selected. CineECGs were computed for the QRS complex and the distance between CineECG location at end QRS was determined per subject for subsequent CineECGs.

Results
In 53 pathogenic mutation carriers ≥2 ECGs were available. 33 pathogenic mutation carriers were diagnosed with definite ACM of whom 4 had an ECG before, at and after diagnosis. Average distance between CineECG location at end QRS was 7.8±6.8 mm. In pathogenic mutation carriers with definite ACM, CineECG before and at diagnosis (figure, example 1&2) were different whereas CineECG at and after diagnosis did not always change. In pathogenic mutation carriers without definite ACM, in 14/19 changes in CineECG were observed (figure, example 3), whereas in the others (figure, example 4) not.

Conclusion
Our preliminary results show that CineECG provides additional insight in the changes of cardiac activation in ACM patients and may enable detection of disease progression. Further analysis will also include cardiac repolarization.
Combined pulmonary vein isolation and cavotricuspid isthmus ablation shows no benefit in recurrence of atrial fibrillation
Authors: Jacinto S , Silva Cunha P , Portugal G , Valente B , Coutinho Cruz M , Lousinha A , Bras P , Delgado AS , Bras M , Paulo M , Guerra C , Teixeira AR , Lacerda Teixeira B , Martins Oliveira M 
Published: May 2022

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Pulmonary vein isolation (PVI) is the mainstay of catheter ablation (CA) for atrial fibrillation (AF). Strategies have been proposed to improve the success rate of CA, such as prophylactic cavotricuspid isthmus (CTI) ablation. Despite some studies providing no, or limited, incremental benefit of CTI ablation in patients with AF, it is still frequently performed worldwide.

Purpose
The aim of this study is to examine whether CTI ablation, combined with PVI, is associated with improvement in recurrence of AF, compared with PVI alone in AF patients with or without atrial flutter (AFL).

Methods
We conducted a retrospective analysis of CA for AF performed at a tertiary center between September 2004 and December 2020. The procedures were divided in two groups: "PVI alone" and "PVI plus CTI ablation". Demographic, clinical, and procedure related data was retrieved. Atrial fibrillation recurrence rate at one year was analyzed for both groups and compared using logistic regression.

Results
A total of 453 procedures were analyzed: PVI alone (n=378; 83.4%) and PVI with CTI ablation (n=75; 16.6%). In the PVI alone group, 12.9% of the patients had concomitant typical AFL and in the PVI plus CTI ablation, 45.8% had typical AFL. Mean age was 57.3±12.1 years, with 63.6% male patients. At one year, AF recurrence rate was higher in the combined PVI with CTI ablation group (30.4%; n=21), compared with the PVI alone group (28.4%; n=97), with no statistical difference between the two groups (Odds Ratio [OD] 1.10; 95% confidence interval [CI] 0.62-1.94; p=0.73). In the subgroup analysis, there was no difference in recurrence between patients with AF without AFL (OR: 1.9; 95% CI: 0.39-9.36; p=0.43), and in patients with AF with concomitant AFL (OR: 10.0; 95% CI: 0.9-110.3; p=0.06).

Conclusion
In AF patients, irrespective of the presence of typical AFL, additional CTI ablation, compared with PVI alone, was not associated with improvement in recurrence of AF.
Zero-fluoroscopy catheter ablation in pregnant women: outcomes and prognosis
Authors: Abdrakhmanov A , Ainabekova B , Nuralinov O , Bakytzhanuly A , Smagulova A 
Published: May 2022

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Arrhythmias are common in pregnant. Catheter ablation is effective treatment in cases of drug refractory arrhythmias. However, data are scarce on outcomes and prognosis of catheter ablation in this population of patient.

Purpose
To define the cohort of pregnant undergoing for catheter ablation for arrhythmias, characterize obstetric and neonatal outcomes and prognosis.

Methods
This single-center, prospective study included all catheter ablation procedures for arrhythmias performed in pregnant from January 2015 until December 2019. Primary outcome was recurrence of arrhythmia. Baseline clinical characteristics, complication rates, obstetric and neonatal outcomes were also evaluated.

Results
In total, we included 48 patients (aged 27.04±4.32 years, mean gestation age 21.8±4.22 weeks), indicated for catheter ablation due to drug refractory arrhythmias. The most common arrhythmia was atrioventricular nodal reentrant tachycardia (n=20; 41.7%). Ablation of accessory pathways performed in 16 cases (33.3%): in left free wall (n=8), in right free wall (n=7), posteroseptal (n=1). In 3 cases was observed combination of accessory pathways with slow conduction ways. Ablation of the right ventricular outflow tract was performed in 9 cases (18.7%) of ventricular tachycardia. In all cases catheter ablation was performed successfully without fluoroscopy. One patient developed an ileofemoral thrombosis. No other complication after ablation was noted. Pregnancy course was benign in all cases without termination. Premature birth was in 2 cases at 35 and 36 weeks of gestation. Full-term pregnancy was in the majority. Preeclampsia developed in 2 pregnant women. In 75% of pregnancy was vaginal delivery, in 25% - Cesarean section. Fetal birth weight was 3226.34±623,1 grams, 5 minute Apgar was 8,92±1,8. There were 48 live births without maternal and fetal mortality. During 1 year follow-up there was no arrhythmia recurrence.

Conclusions
Non-fluoroscopic catheter ablation of arrhythmias in pregnant women is effective treatment options, with a high success rate, low rates of complication, favorable outcomes and prognosis.
Effect of a proactive esophageal cooling device on procedure length - a multicenter comparison of persistent and paroxysmal atrial fibrillation
Authors: Joseph C , Francisco G , Ruppert A , Willms D , Metzl M , Fisher W , Nazari J , Ro A , Zagrodzky J , Zagrodzky W , Sherman J , Bailey S , Athill C 
Published: May 2022

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
During left atrial ablation for the treatment of atrial fibrillation (AF), effective esophageal protection is essential for reducing or preventing thermal injury. Traditional methods include luminal esophageal temperature (LET) monitoring that lead to frequent pauses in the procedure when temperature alarms alert operators to dangerous temperature levels. While there have been recent studies that demonstrate an association between active esophageal cooling and a reduction in procedure duration regardless of AF type, these retrospective studies have been conducted at single or joint centers which may lead to confounding from other time-saving variables that have changed over time.

Purpose
Consequently, we sought to perform a large-scale multicenter comparison to better elucidate the association between procedure length and the use of active cooling in patients with persistent and paroxysmal atrial fibrillation.

Methods
In this study, we collected data from three large hospital centers, one hospital-maintained registry, one physician-maintained registry, and one through EHR data review and aggregated in groups separated by AF type as well as whether the patients received active cooling or LET monitoring. We then compared median procedure durations in each group.

Results
There were a total of 753 patients included in this study. Of the 360 patients with paroxysmal AF, 179 received active esophageal cooling while 181 underwent LET monitoring. In the persistent AF group with 393 patients, 157 received active esophageal cooling and 236 underwent LET monitoring. Among patients with paroxysmal AF, the median mean procedure duration was 137 minutes in the LET monitored group, and 90 minutes in the actively cooled group with an overall reduction of 47 minutes (P&lt;.001). In patients with persistent AF, the median procedure duration was 148 minutes in the LET monitored group and 94 minutes in the actively cooled group with an overall reduction of 54 minutes (P&lt;.001). The relative reduction as a percent of total procedure time was 34%, and 36%, for paroxysmal and persistent AF cases, respectively.

Conclusion
In this large multicenter review, there is a significant reduction in procedure length when using active esophageal cooling, regardless of AF type.
Is it possible to predict mortality and recurrence of VT afterablation? PAINESD risk score applicability vs new predictors
Authors: Martins AM , Silverio Antonio P , Couto Pereira S , Brito J , Valente Silva B , Alves Da Silva P , Garcia AB , Simoes De Oliveira C , Nunes Ferreira A , Lima Da Silva G , Carpinteiro L , Cortez-Dias N , Pinto FJ , De Sousa J 
Published: May 2022

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Catheter ablation (CA) prevents ventricular tachycardia (VT) recurrences in patients (pts) with structural heart disease (SHD), and might have a favorable outcome, but is associated with severe short-term complications. Identification of pts at high risk of periprocedural acute haemodynamic decompensation has important implications at procedural planning.
The PAINESD risk score is a promising tool to predict VT ablation procedure-related mortality.

Aim
To evaluate the accuracy of the PAINESD risk score to predict short-term mortality after structural VT ablation and to compare it with other conventional clinical predictors.

Methods
Prospective, observational, single-centre study of consecutive pts with SHD (ischemic or nonischemic), referred for VT-CA. High-density substrate maps were collected, through endocardial, epicardial or combined endo-epicardial approaches according to clinical data and operator preference. The primary endpoint was 30-day mortality or hemodynamic decompensation. Univariate Cox regression analysis was used to identify relevant clinical predictors and to compare them with the PAINESD risk score. Multivariable Cox proportional hazards regression models were used to estimate predictors of 30-day mortality.

Results
A total of 102 pts with SHD referred for VT ablation were evaluated(mean age: 67±11 years, 94% male, 78.4% in NYHA class I-II; mean LVEF was 34±11%). The baseline PAINESD risk score was 12.39±5.8, 19.6% at low risk, 36.3% at intermediate risk and 27.5% at high risk of adverse events. Overall 30-day mortality was 4.9%. The PAINESD did not predict 30-days mortality or hemodynamic decompensation (p= 0.93). Indeed, a non- significant trend to higher short and long-term mortality was noticed in high-risk score pts – Figure 1. On univariate analysis age&gt;65 years (p=0.019), LVEF &lt;35% (p=0.049), body mass index&lt;28kg/m2 (p=0.019), CKD (p=0.001) and previous VT ablation (p=0.022) were prognostic predictors. On multivariate analysis, only LVEF&lt;35% (HR2.225; CI95% 1.004-4-774,p=0.038) and CKD (HR 3.35; CI95%: 1.31-8.51, p=0.011) were independent predictors of short-term prognosis.

Conclusions
In our population, LVEF&lt;35% and CKD were the strongest predictors of short-term mortality. PAINESD risk score was not accurate in predicting adverse events. New score systems must be derived for prognostic stratification in this population, incorporating the reduction on the actual short-term event rates after VT ablation.
Rapid mode in novel generation visually guided laser balloon system: feasibility, safety, and impact on procedural outcomes
Authors: Martignani C , Ziacchi M , Statuto G , Spadotto A , Angeletti A , Massaro G , Bartoli L , Orlandi M , Diemberger I , Ginex S , Provasi F , Grassini D , Galie N , Biffi M 
Published: May 2022

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Laser balloon (LB) systems are increasingly used for pulmonary vein isolation (PVI) in catheter ablation of atrial fibrillation (AF). The novel generation of the visually guided LB system includes a rapid mode (RM) feature, which potentially allows a continuous circumferential lesion for PVI. Nevertheless, data on its practicability and on its impact on procedural outcomes are lacking.

Purpose
To analyse the applicability of RM and its effect on procedural and fluoroscopic time in a cohort of patients who underwent catheter ablation of AF using a LB system.

Methods
Between September 2020 and December 2021, we prospectively included all consecutive patients who underwent PVI with LB at our centre. All the procedures were performed by the same two operators. For each pulmonary vein (PV), we firstly attempted to obtain a complete circumferential lesion at 13 W using the RM. If its application was not possible or incomplete, we performed additional single lesions at 5.5, 8.5 or 13 W to achieve complete visual PVI. Finally, we calculated the percentage of singular and total circumferential lesions made with RM for every procedure and evaluated its influence on procedural outcomes.

Results
75 patients were enrolled. We identified and successfully isolated 289 PVs, with mean procedural and fluoroscopic time of 171±51 and 38±15 min, respectively. Use of RM for more than 70% of the circumferential lesion was possible in 185 veins (64%), while we obtained complete isolation using only RM in 90 veins (31%). Reasons for interruption of RM were unfavourable anatomy, imperfect visualization of the ostium of the PV and presence of blood between the balloon and the anatomic substrate. For each vein, we observed a significantly shorter ablation (13±8 vs 23±12 min, p&lt;0.001) and fluoroscopic time (3±3 vs 5±4 min, p&lt;0.01) if &gt;70% of the circumferential lesion was made through RM. Further, total procedural (157 ±52 vs 192±42 min, p&lt;0.01), ablation (53±17 vs 88±27, p &gt;0.001) and fluoroscopic time (30±15 vs 36.9±14 min, p 0.025) were significantly shorter if more than 70% of total circumferential lesion was achieved through rapid mode. There were five pinhole balloon ruptures during application of RM. No major complication occurred.

Conclusions
RM is a novel feature in the latest generation of LB system. In our cohort, it showed good applicability and safety, while significantly reducing procedural times. Further studies are needed to understand its possible impact on clinical outcomes.
Quantifying the variability of bipolar voltage amplitude with sensing angle in residual conduction isthmuses in atrial scar
Authors: Merino JL , Kim S , Relan J , Castrejon Castrejon S , Sanroman M , Escobar Cervantes C , Martinez Cossiani M , Carton A 
Published: May 2022

Abstract

Funding Acknowledgements
Type of funding sources: Private company. Main funding source(s): Abbott

Background
The angle between the activation wavefront and bipole may conceal the conduction isthmus in conventional bipolar voltage mapping, but the extent of variability of electrogram (EGM) voltage amplitude with directional changes has not been quantified.

Purpose
Using a well-defined model of discrete atrial conduction, we sought to use Omnipolar Technology (OT) to assess variability of voltage amplitude as a function of sensing angle, in sites of residual conduction and scar tissue.

Methods
During redo pulmonary vein isolation (PVI) procedures, baseline voltage maps were acquired during coronary sinus pacing (500 ms) using a rectangular 16-pole catheter (HD Grid). During retrospective analysis with OT research software, all EGM’s ≤1 cm radius from the site of PVI were classified as GAP (vs No-GAP; Panel A) The variability of voltage amplitude (OT-ΔV) with sensing angle (θ) was computed as the difference between the maximum and minimum voltages (OT-Vmax - OT-Vmin), in both GAP and No-GAP subregions (Panels A & B).

Results
23 GAP sites were identified in 12 of 15 consecutive patients studied. 3464 EGM’s (1386 GAP vs 2078 No-GAP) were analyzed. Global mean OT-ΔV was 0.46±0.80 mV. GAP regions showed significantly (P&lt;0.0001) higher OT-ΔV as compared with No-GAP regions (0.80±1.03 mV vs 0.24±0.47 mV respectively; Panel C) The mean Δθ angle for OT-ΔV was similar in both GAP and No-GAP regions (88.6±11.3° vs 88.0±13.6°, P=0.1; Panel D).

Conclusion
The variability of voltage amplitude as a function of bipole orientation can be significant, especially in GAP regions (0.80±1.03 mV). (2) OT-ΔV holds promise for identification of residual conduction within atrial scar tissue.
Early local impedance drop during pulmonary vein isolation using a novel contact force sensing catheter is associated with acute lesion efficacy
Authors: Perge P , Sallo Z , Piros K , Nagy VK , Osztheimer I , Merkely B , Geller L , Szegedi N 
Published: May 2022

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
The predictive role of adequate local impedance drop in lesion formation using a novel contact force sensing ablation catheter for pulmonary vein isolation was recently described. The purpose of our pilot study was to assess the temporal characteristics of local impedance drop and its correlation with acute lesion efficacy.

Methods
Point-by-point radiofrequency pulmonary vein isolation was performed with 50 W energy setup in power-controlled mode. The efficacy of applications was assessed by pacing along the circular ablation line. We considered the lesions successful if loss of capture was achieved. Local impedance, contact force and catheter position data of the applications with 10 msec resolution was analysed. The local impedance of successful and unsuccessful applications was compared at baseline and 2, 4, 6, 8 and 10 sec time points, respectively. We characterized the local impedance for each time point with the mean of the 5 impedance value closest in time.

Results
184 applications were analysed, 167 were successful and 17 were unsuccessful. There was no difference in mean contact force (p=0.142) and contact force range (p=0.606) between successful and unsuccessful applications. The baseline local impedance was significantly lower in the unsuccessful group (p&lt;0.0001), while successful applications had significantly larger local impedance drop at the 2 (p=0.0006), 4 (p&lt;0.0001), 6 (p=0.0066), 8 (p=0.016) and 10 sec (p=0.0106) time points compared with the unsuccessful group. Local impedance did not change significantly over time in case of unsuccessful applications (p=0.192), while it decreased significantly in case of successful applications (p&lt;0.0001).

Conclusion
Early rapid drop of the local impedance may predict effective lesion formation, while slowly changing or unchanged local impedance is associated with unsuccessful applications. In case of a slow local impedance drop during the first 6 seconds of radiofrequency application, it might be reasonable to stop the application and start a new one after catheter repositioning.
Untargeted toxicology in sudden cardiac arrest victims
Authors: Stampe NK , Glinge C , Rasmussen BS , Bhardwaj P , Linnet K , Jabbari R , Hassager C , Kjaergaard J , Tfelt-Hansen J , Winkel BG 
Published: May 2022

Abstract

Funding Acknowledgements
Type of funding sources: Public grant(s) – EU funding. Main funding source(s): European Union’s Horizon 2020 research and innovation programme to J.T.-H under acronym ESCAPE-NET

Background
Sudden cardiac arrest (SCA) is a major public health challenge and is associated with poor outcomes. Many drugs are known to increase risk of arrythmias and ultimately sudden cardiac death. To our knowledge an untargeted toxicological analysis has not previously been performed in an initially resuscitated SCA cohort.

Purpose
We aimed to determine the qualitative and quantitative drug composition present in SCA patients by using forensic toxicological analytical chemistry of all illicit, non-prescription and prescribed drugs, and further investigate whether these drugs are in therapeutic levels or overdosed and to correlate the clinical findings with the toxicology results.

Methods
We performed a prospective single-tertiary-center study and included all SCA victims (aged 18-90 years) admitted to our cardiac intensive care unit, between February 2019 to November 2019 (Figure 1). Traumatic and overt overdose related SCA were not included in the study. Drugs used during resuscitation and administered prior to sample collection were identified in each patient and excluded.

Results
We prospectively identified 85 all-cause SCA patients with a median age of 60 years (IQR: 53-71) and male predominance (80%). The majority had a shockable rhythm as first rhythm (95%). The major cause of cardiac arrest was acute and chronic ischemia (56/77, 66%), followed by cardiomyopathy (9/77, 12%), idiopathic ventricular fibrillation (8/77, 10%), bradycardia (2/77, 2.6%), primary arrhythmia (1/77, 1.3%), other (1/77, 1.3%). The remaining 8 patients (9.4%) died prior to diagnosis.
A positive toxicology was identified in 67 patients (79%) with a total of 218 detected drugs. The most frequent drugs were mild analgesics (32/85, 38%), beta-blockers (21/85, 25%) and ACE-inhibitors/ARB (20/85, 24%). A total of 9 (11%) patients had one or more potentially abusable drugs detected, with the most common being opioid agonists in 5 patients (Figure 2). Importantly, all drugs were found at sub-therapeutic or therapeutic concentrations. None had overdose concentrations. Moreover, polypharmacy was common and a median of 2 drugs (IQR: 1-4) were detected (excluding caffeine that was detected in 83 patients).

Conclusion
We found that the majority had drugs detected, and polypharmacy is displayed in a considerable proportion. Potentially abusive drugs were encountered in 11%. However, we did not identify any occult overdose related cardiac arrests among all resuscitated SCA patients. In our setting, toxicological screening in cardiac arrest patients who is not obviously overdosed is excessive.