bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease
Authors: Kozhevnikova M. V. , Krivova A. V. , Korobkova E. O. , Ageev A. A. , Shestakova K. M. , Moskaleva N. E. , Appolonova S. A. , Privalova E. V. , Belenkov Yu. N. 
Published: December 2022

Aim To compare serum concentrations of tryptophane (Trp) and its metabolites in subjects with no cardiovascular disease (CVD) and patients with СVD, including arterial hypertension (AH) and ischemic heart disease (IHD).Material and methods This study included 131 participants; 58 participants (11 of them with documented peripheral atherosclerosis) were included into the AH group, 46 participants were included into the IHD group, and 27 participants with no signs of CVD were included into the control group. Plasma concentrations of Trp and its metabolites were measured by high-performance liquid chromatography in combination with a triple quadrupole analyzer.Results Comparison of the three study groups revealed significant differences in concentrations of Trp (р=0.029), kynurenine (p<0.001), kynurenine/Trp ratio (p<0.001), quinolinic acid (р=0.007), kynurenic acid (р=0.003), serotonin (p<0.001), and 5‑hydroxyindoleacetic acid (5‑HIAA) (р=0.011). When the AH group was subdivided into subgroups without and with documented peripheral atherosclerosis, the intergroup differences remained for concentrations of kynurenine, kynurenine/Trp ratio, quinolinic acid, kynurenic acid, serotonin, and 5‑HIAA. Also, correlations were found between concentrations of Trp metabolites and laboratory and instrumental data, primarily inflammatory markers. Conclusion Analysis of serum concentrations of Trp and its metabolites in CVD patients showed increases in kynurenine, kynurenine/Trp ratio, quinolinic acid, kynurenic acid, and 5‑HIAA along with decreases in concentrations of Trp and serotonin in the groups of AH, AH with documented peripheral atherosclerosis, and IHD.
Pola Pendidikan Karakter Santri di Pondok Pesantren Hikmatusysyarief NW Salut
Authors: Yuslih Muhammad , Hafiz Abdul 
Published: December 2022

This study aims to determine the pattern of character education for students at the Islamic boarding school Hikmatusysyarief NW Salut. This research is included in the type of descriptive qualitative research. The data collection was carried out in three ways: observation techniques, interviews, and documentation. Data analysis follows the Miles-Huberman stage: data reduction, data display, and drawing conclusions or verification. The study results show that the patterns and methods of character education at the Islamic boarding school Hikmatusysyarief NW Salut include them. First, the khalaf pattern, from this khalaf pattern formed the character of students who are creative, fond of reading, honest, peace-loving, communicative, and democratic. The second is the boarding school (dormitory) pattern; from this pattern, the students' character is formed who are religious, honest, tolerant, communicative, care for the environment, care for the social, and love peace. Then the third pattern is the semi-military pattern. This pattern forms the character of students who are responsible, disciplined, independent, and hardworking. The pattern used is completely under the control of the Hikmatusysyarief Islamic boarding school assistants for almost 24 hours. The application of this pattern is intended so that after they graduate, they can live within the norms that have been agreed upon by the community where they live, as well as in the world of work.
Keywords: Pattern, Character Education, Islamic Boarding School, Hikmatusysyarief Islamic Boarding School
Penelitian ini bertujuan untuk mengetahui pola pendidikan karakter santri di pondok pesantren Hikmatusysyarief NW Salut. Penelitian ini termasuk ke dalam jenis penelitian kualitatif deskriptif. Adapun pengumpulan data dilakukan dengan tiga cara yaitu teknik observasi, wawancara, dan dokumentasi. Sementara analisis data mengikuti tahap Miles-Hubermen yaitu reduksi data, kemudian display data, dan yang terakhir penarikan kesimpulan atau verifikasi. Dari hasil penelitian menunjukkan bahwa pola dan metode pendidikan karakter dipondok pesantren Hikmatusysyarief NW Salut diantaranya. Pertama, adalah pola khalaf, dari pola khalaf ini terbentuk karakter santri yang kreatif, gemar membaca, jujur cinta damai, komunikatif, dan demokratis. Yang kedua pola boarding school (asrama), dari pola ini terbentuk karakter santri yang religius, jujur, toleran, komunikatif, peduli lingkungan, peduli sosial dan cinta damai. Kemudian pola yang ketiga adalah pola semi militer dari pola ini terbentuk karakter santri yang bertanggung jawab, disiplin, mandiri, dan pekerja keras. Pola yang digunakan ini sepenuhnya dalam kendali para asatiz ponpes Hikmatusysyarief hampir selama 24 jam. Tentu penerapan pola ini, dimaksudkan agar setelah mereka lulus dapat hidup dalam norma-norma yang telah disepakati oleh masyarakat tempat tinggalnya, serta di dunia kerja.
PENANGGULANGAN ORIENTASI LGBT PADA ANAK USIA BALIGH
Authors: Iin Yuniarni  , Derysmono Derysmono 
Published: December 2022

The Citayam Fashion Week (CFW) event in July 2022, -led by amateur teenagers-, suddenly became virtual in cyberspace. The massive emergence of the lifetrend of young groups of lesbian, gay, bisexual and transgender or popularly referred to as LGBT on the event of CFW, rekindled diverse polemics in the social realities of society at large. Although since 2001 when the Netherlands first until now almost 30 other countries have consciously officially legalized the LGBT movement, the LGBT phenomenon which is categorized as a form of deviation of sexual orientation, in fact LGBT is still a long discourse and has not ended either among academics, practitioners or the wider community. The arguments are manifold; starting from the change in LGBT status from the master book of psychology (DSM) Diagnostic and Statistical Manual of Mental Disorder, namely from the category of sexual deviance orientation to the category of orientation that seems natural and commonplace, to the arguments of the Holy books including the Qur'an with postulates whose verses are clear and well established.
This research applies an analytical descriptive qualitative methodology, based on the Qur'ani of psychology using nomatic techniques, to find prevention from the orientation of LGBT towards children at young age . The results reveal the phenomenon of LGBT psychiatry and the impact of LGBT life trends on “baligh” age in the contemporary digital age. This study offers 4 continuums of the Qur'ani cognitive adjustment models, namely: 1. To strengthen moral education and applied theory of cognition husn al-Zahn/positive attribution, 2. To strengthen family resilience, 3. To choose a good social environment, 4. To synergy between the government, the legislator and the formation of law against LGBT.
IMPLIKASI POLA ASUH ORANGTUA TERHADAP KECERDASAN EMOSIONAL ANAK USIA DINI DI TK PGRI 1 CAMPLONG SAMPANG
Authors: Astuti Ria , Rofi'ah  
Published: December 2022

Penelitian ini bertujuan untuk mendeskripsikan implikasi pola asuh orangtua terhadap kecerdasan emosional anak usia dini. Jenis penelitian ini adalah kualitiatif deskriptif dengan Teknik pengumpulan data wawancara, observasi, dan dokumentasi. Sumber data dalam penelitian ini adalah orang tua TK PGRI 1 Taddan Camplong Kabupaten Sampang, anak usia dini, kepala sekolah serta Guru TK. Teknik analisis data menggunakan reduksi data, display data, serta verifikasi data. Sedangkan teknik pengecekan datanya melalui perpanjangan keikutsertaan, ketekunan pengamatan, triangulasi. Hasil penelitian menunjukkan bahwa orangtua berperan penting dalam mendidik atau mengasuh anak. Pola asuh yang diterapkan orangtua terhadap anaknya di TK ini adalah: demokratis, orang tua yang berambisi, orang tua yang membandingkan anaknya dengan anak lain, dan orang tua yang otoriter. Implikasi pola asuh orangtua terhadap kecerdasan emosional anak usia dini, meliputi: Cenderung tidak ramah dan pemalu, kurang pengendalian diri terhadap emosionalnya, kurang empati, sulit beradaptasi dengan orang lain, kurang percaya diri, dan penakut.
THE EFFECTIVENESS OF UNIVERSAL HEALTH PROGRAM SOCIALIZATION BY BPJS KESEHATAN TO THE COMMUNITY OF MATARAM CITY
Authors: Windy Tria Widyantari , Muchammadun  , Andri Kurniawan  
Published: December 2022

Factors that cause the lack of interest of the public to use BPJS services are assumptions that it is useless to use BPJS if it is not used, let alone having to register a family. The case is that the underprivileged community becomes twice-minded and burdensome to them. This research uses qualitative research. The data collection method used is an interview, observation, and documentation, while the analysis method used is interactive model analysis. The results showed that the socialization of BPJS Kesehatan is very important for the community. However, BPJS Kesehatan in Mataram city its programs in several sub-districts and the lack of socialization makes people not know about the importance of BPJS Kesehatan. The conclusion of the study shows that BPJS Kesehatan has not been optimal in conducting socialization which makes some people say that BPJS socialization is not effective.
KONTRIBUSI SYAIKH NURUDDIN AR-RANIRY SEBAGAI QADLI DI KERAJAAN ACEH DARUSSALAM ABAD KE-17 M
Authors: Imawan Dzulkifli Hadi 
Published: December 2022

Studi ini menjelaskan kontribusi Syaikh Nuruddin al-Raniry sebagai hakim di Kerajaan Aceh Darussalam Abad ke-17. Jabatan hakim di Kerajaan Aceh Darussalam pada abad ke-17 M merupakan jabatan tinggi yang disebut sebagai qadli malikul adil. Diantara ulama yang memiliki kontribusi besar dalam peradilan saat itu adalah Syaikh Nuruddin al-Raniri. Oleh karena itulah, studi ini bertujuan untuk menelusuri kontribusi Syaikh Nuruddin ar-Raniry dalam membumikan hukum Islam lewat karyanya As-Shirath al-Mustaqim. Metode penelitian menggunakan kajian pustaka; studi diskriptif kualitatif dengan analisis-historis untuk menemukan data-data tentang kontribusi Syaikh Nuruddin ar-Raniry. Hasil kajian ini menjelaskan bahwa Syaikh Nuruddin ar-Raniry sebagai hakim berkontribusi besar dalam membumikan hukum Islam madzhab Syafi’idan mendorong literasi fikih Islam di Nusantara.

This study explains the contribution of Shaykh Nuruddin al-Raniry as a judge in the 17th Century Kingdom of Aceh Darussalam. The position of judge in the Kingdom of Aceh Darussalam in the 17th century AD was a high position called qadli malikul just. Among the scholars who had a major contribution to the judiciary at that time was Shaykh Nuruddin al-Raniri.Therefore, this study aims to explore the contribution of Shaykh Nuruddin ar-Raniry in grounding Islamic law through his work As-Shirath al-Mustaqim. The research method uses literature review; qualitative descriptive study with historical analysis to find data about the contribution of Shaykh Nuruddin ar-Raniry. The results of this study explain that Shaykh Nuruddin ar-Raniry as a judge contributed greatly in grounding the Islamic law of the Syafi’imadhhab and encouraging Islamic fiqh literacy in the archipelago.
PEMBERIAN GELAR PENGHORMATAN PENGAGENG DAN ABDI DALEM KASUNANAN SURAKARTA HADININGRAT DALAM PERSPEKTIF SOSIOLOGI
Authors: Malik Muhammad , Muhammad Akbar Terbangsyah  , M. Muslich KS  
Published: December 2022

Karaton Surakarta Hadinigrat Hadinigrat merupakan salah satu kerajaan yang masih berdiri hingga saat ini meskipun tidak memiliki kekuasaan dalam mengatur tata pemerintah seperti dahulu dikarenakan telah ditetapkan oleh pemerintah Indonesia sebagai sebuah simbol budaya berdasarkan Undang-undang No 32 tahun 2004 tentang pembentukan daerah dan Kawasan khusus. Walaupun telah ditetapkan demikian, kegiatan budaya terus dilakukan oleh karaton kasunanan Surakarta demi menjaga warisan budaya yang telah ditinggalkan oleh para pendahulu untuk tetap dilestarikan dari masa ke masa dengan bantuan para abdi dalem. Tak hanya keturunan raja, para abdi dalem juga memiliki nama-nama khusus yang diberikan oleh karaton kasunanan Surakarta hadinigrat sebagai sebuah simbol dan bentuk penghormatan kepada mereka yang disebut dengan istilah gelar penghormatan. Penelitian ini merupakan studi lapangan dengan pendekatan sosiologis dan menggunakan data primer yang diperoleh dari hasil wawancara. Data hasil wawancara tersebut akan dianalisis kemudian di deskripsikan dengan cermat sesuai dengan data yang telah didapatkan. Hasil dari penelitian ini Pertama, Karaton Surakarta Hadinigrat pada masa sekarang hanya berperang sebagai pemangku kebudayaan. Salah satu budaya yang masih lestari di karaton adalah pemberian gelar penghormatan. Gelar ini diberikan dalam sebuah acara resmi (psiowanan) wisudan bertempat di Bangsal Samarakanta. Kedua, bagi masyarakat modern pemberian gelar tentu tidak memiliki fungsi lebih apabila itu digunakan dalam keseharian sebagai warga negara Indonesia. Ia akan memiliki nilai dan kehormatannya dalam sebuah tempat yang sesuai, yakni negara-negara kerajaan. Hal ini mempertimbangkan historis dari pada Karaton Surakarta Hadinigrat.
An Empirical Study to Evaluate the Impact of Mindfulness on Helpdesk Employees
Authors: Jiménez Beatriz Bernárdez , Navarrete Ignacio Panach , Maestre Jose Antonio Parejo , Toro Amador Durán , Juzgado Natalia Juristo , Ruiz-Cortés Antonio 
Published: December 2022

Abstract
Purpose: The practice of mindfulness aims to improve concentration and attention, which has proven useful in knowledge-intensive and stressful work environments like technological companies. This article aims to find empirical evidence on the positive effect of the practice of mindfulness on a sample of 56 helpdesk employees working for a consulting and information technology company (Accenture) with respect to: i) their attention awareness; ii) a set ofkey performance indicators (KPIs); and iii) the perceived benefits of mindfulness.
Method: Of the 56 recruited employees, 29 worked as managers, and 27 worked as agents answering phone calls to solve software issues of the main information system of the Andalusian Health Service, a public organization withmore than 115,000 employees. The treatment was applied to 26 subjects, while the other 30 subjects were the control group. For all subjects, their attention awareness was measured using the MAAS scale.
Results: Both helpdesk managers and agents significantly improved their attention awareness with respectto the control group. Regarding organizational KPIs, in general, no evidence of significant differences between groups was detected, apart from the fact that the number of phone calls answered was significantly lower in the mindfulness group, probably due to a longer call duration caused by a deliberate better attention to the customer, but without degrading any other KPI. Results yield relevant benefits perceived by most employees after practicing mindfulness.
Conclusions: We confirm that the practice of mindfulness improves attention awareness and benefits the working and personal life of helpdesk employees. However, further research is needed to identify a clear impact on productivity.
Chromatographic separation of tiropramide hydrochloride and its degradation products along with their structural characterization using LC-QTOF-MS/MS and NMR
Authors: Tidke Manik , Golla Vijaya Madhyanapu , Kushwah Bhoopendra Singh , Naik Dhanavath Dattu , Samanthula Gananadhamu 
Published: December 2022

Abstract
Tiropramide HCl, an antispasmodic drug is subjected to various stress conditions (hydrolytic, oxidative, photolytic and thermal) as per ICH guidelines. The drug is widely used as an antispasmodic agent but there were no comprehensive degradation studies reported on it. Hence, forced degradation studies of tiropramide HCl were carried out to establish the degradation profile and the storage conditions to maintain its quality attributes during the shelf life and usage. A selective HPLC method was developed to separate the drug as well as all of its degradation products using Agilent C18 (250×4.6 mm; 5 µm) column. The mobile phase of 10mM ammonium formate at pH 3.6 (solvent A) and methanol (solvent B) with gradient elution at a flow rate of 1.00 mL/min was used. Tiropramide was susceptible to acidic, basic hydrolytic exposure and oxidative stress conditions in the solution. This drug was found to be stable in neutral, thermal and photolytic conditions in both solution and solid-state. Five degradation products were detected under different stress conditions. The mass spectrometric fragmentation pattern of tiropramide and its degradation products was extensively studied using LC-Q-TOF-MS/MS for their structural characterization. The position of the oxygen atom in the N-oxide degradation product was confirmed by NMR studies. The knowledge gained by these studies was used to predict drug degradation profiles which is helpful in the development of the dosage form.
Contribution of remote sensing to wildfire trend and dynamic analysis in two of Ghana’s ecological zones: Guinea-savanna and Forest-savanna mosaic
Authors: DAHAN Kueshi Sémanou , KASEI Raymond Abudu , Husseini Rikiatu 
Published: December 2022

Abstract

Background Two of Ghana’s ecological zones—Guinea-savanna zone (GSZ) and Forest-savanna mosaic zone (FSZ)—are practically homologous in terms of structure and floristic composition, with some differences. The various sub-ecosystems that make up these areas are being depleted and losing their natural values due to various threats. There is little understanding about the fire trends in these areas due to lack of data and poor accessibility to existing fire statistics. This study aimed to contribute to the understanding of the trends of area burned and active fire in the Guinea-savanna and Forest-savanna mosaic zones in order to inform policy-makers about sustainable management options. We used the Moderate Resolution Imaging Spectroradiometer (MODIS) daily active fire (MDC14ML) and burned-area (MCD64A1) products to characterize the fire regime in terms of seasonality, intensity, density, a burned area, frequency, and the trends during the study period of 2001 to 2021.
Results This study indicated that fire activity started in October and peaked in December (GSZ) and January (FSZ). The mean proportion burned was approximately 39.95% or a burnt area of 2659.31 km2 (FSZ) and 60.05% or a burnt area of 3996.63 km2 (GSZ), while the frequency was approximately 42.87% or 1759.95 of active fires (FSZ) and 57.13% or 2345.26 of active fires (GSZ). In the year 2018 GSZ recorded the largest burned area (19 811.2 km2 or an average of 825.5 km2) with 4719 active points detected whereas the FSZ recorded its greatest burned area in 2015 (8727.4 km2) with 5587 active points recorded, which represents an average of 363.6 km2 of area burned of the total area burned (2001-2021). In addition, it was found that specific times of the day (1000 hours to 1420 hours) recorded the majority of burned areas.
Conclusions In conclusion, the trend is decreasing for the area burned, and increasing for the number of fires. This study demonstrated the relevance of remote sensing to describe spatial and temporal patterns of fire occurrence in Ghana and highlighted the need for fire control and fuel management by the policies and institutions (e.i: Ghana National Fire and Rescue Service) in these important and vulnerable zones (GSZ and FSZ), especially in the Forest-Savannah zone, which is increasingly affected by the disasters of wildfires and records more and more of active fires than GSZ. Therefore, rigorous continuous monitoring is essential in collaboration with organizations fighting for the conservation of natural resources in the field is strongly recommended.
Evaluation of Peripheral Nerve Injury According to the Severity of Damage Using 18F-FDG PET/MRI in a Rat Model of Sciatic Nerve Injury
Authors: Park Jong Yeol , Lee Mi Jee , Kim Hyung Jun , Nam Jung Woo 
Published: December 2022

Abstract
Reports suggest a high incidence of nerve injuries, and diverse methods, such as two-point discrimination and the pin prick test, have been attempted to evaluate the severity of nerve damage. However, these tests rely on subjective sensations and may not accurately represent the damaged area. A previous experiment revealed that 18F‑FDG positron emission tomography/magnetic resonance imaging (PET/MRI) detect peripheral nerve damage. This study aimed to assess peripheral nerve damage according to severities of damage using 18F-FDG PET/MRI in a rat sciatic nerve. Eighteen rats were divided into three groups: 30-second (G1), 2-minute (G2), and 5-minute (G3) crushing injury groups. The severity of nerve damage was measured in the third week after the crushing injury using three methods: revised withdrawal threshold (RevWT)), standardized uptake values ratio on PET/MRI (SUVR), and immunohistochemistry (intensity ratio (IntR)). There were significant differences between G1 and G3 in both SUVR and IntR. There were no significant differences in both SUVR and IntR between G2 and G3 and no significant differences in RevWT among the three groups. There was a significant difference in SUVR but no significant difference in IntR between G1 and G2. Although PET/MRI did not show results consistent with the immunohistochemistry in all respects, this study demonstrated that the severity of nerve damage as assessed by PET/MRI increased with a longer crushing time. PET/MRI showed potential as an objective diagnostic tool in this peripheral nerve injury model. If research is supplemented through further experiments, PET/MRI can be used as an effective diagnostic modality.
The Effect of Using Cooperative Learning in L2 Writing Class: a Quasi-Experimental Study
Authors: Abtew Asafew Kelebu 
Published: December 2022

Abstract
The study endeavored (1) to assess the effect of using cooperative learning on EFL students’ over all writing performance (2) to assess which writing aspect (fluency, accuracy or complexity) was developed as a result of cooperative learning. Nine grade 9 students (453 students) were the total population. The researcher selected 2 section students using the purposive sampling technique. To label the control and experimental groups, simple lottery sampling was used. The treatment was given for11weeks (two hours per week). Data was gathered using a writing test. T-test (both independent and paired samples T-test) was employed as a statistical tool of analysis. The result of the study showed that the experimental group of students overall writing post-test result was greater than their pre-test result and that of the control group’s post-test results. In addition, their post-test mean score was greater than their pre-test means scores, and that of the control group’s post-test results in fluency and accuracy but not in complexity. Finally, it was concluded that using the cooperative learning method is better to improve EFL students’ overall writing performance. Judicious and cautious employment of cooperative learning during writing was suggested as a pedagogical implication.