bluuebunny/crossref_metadata_2025_split huggingface dataset:
Puppets Pulling Back: Drawing Out Wael Shawky's Histories
Authors: Taylor Damian 
Published: March 2022

Abstract
Recounting the first four Crusades using an evolving cast of marionettes, Wael Shawky's Cabaret Crusades trilogy is widely interpreted as exploring the construction of history. Close attention to the puppet performances, however, suggests that far more is at play than literalizing how the players on life's stage are caught up in history and swept along by external forces. For example, the identity of puppet and puppeteer is frequently destabilized, an instability achieved as much through the possibilities of video as within the material exchanges of puppet and puppeteer. The essay investigates several questions: What questions are posed regarding the interactions of human agency and matter when the marionette becomes the marionettist through the mediation of video? How might this push up against the more obvious histories that Shawky interrogates? And, ultimately, how does this revised form of representation transform understandings of that which the puppet has long represented—the very condition of the human?
Analysing Russian Reaction to 2021 U.S. Capitol Riots
Authors: Slutskiy Pavel , Gavra Dmitrii 
Published: March 2022

On January 6, 2021, the United States Capitol in Washington, D.C. was attacked by a mob of supporters of President Donald Trump. More than 70 countries and international organisations expressed their concerns over the 2021 United States Capitol attack and condemned the violence. While governments around the world have expressed outrage and sadness over rioting that engulfed the U.S. Capitol, some media (for example, VOA) reported that ‘Russia took a different view -- namely, vindication with a bit of gloating’ under the headline ‘As US Reels From Capitol Violence, Russia Enjoys the Show’. What was Russia’s reaction to the events in Washington? Russian high-ranking politicians responses to the U.S. Capitol rioters were widely quoted in English-speaking media. But the angle offered for foreign audiences did not always coincide with the media narrative developed for domestic consumption. This paper examines media interpretation of the U.S. riots which was offered by the Russian media for Russian-speaking audiences. The paper follows the discourse of pro-Kremlin media during the period of 1 month after the protests began, analysing discursive frames which represented different interpretations of the events, particularly within the context of comparing the suppression of opposition protests in Russia with the prosecution of the U.S. Capitol rioters.
Economic Burden Associated With Nasal Polyposis Recurrence Among Commercially Insured Patients in the United States
Authors: Zhdanava Maryia , Ndife Briana , Pilon Dominic , Rossi Carmine , Vermette-Laforme Maude , Lefebvre Patrick , Suh Jeffrey D. 
Published: March 2022

AbstractObjectiveTo compare health care resource utilization (HRU) and costs among commercially insured patients with nasal polyposis (NP) with and without recurrence after endoscopic sinus surgery (ESS).Study DesignRetrospective matched cohort study.SettingAdults with initial ESS or an NP excision after a new NP diagnosis were identified in Optum’s Clinformatics Data Mart Database (October 1, 2014–December 31, 2019).MethodsThe index date was the date of NP recurrence, identified with a claims‐based algorithm for the recurrent cohort, or a random date for the nonrecurrent cohort. Patients in both cohorts were matched 1:1 on baseline characteristics (12 months preindex) via propensity scores and exact matching factors. Annual HRU and costs (2019 US$) were compared between the matched cohorts at 12 months postindex.ResultsNP recurrence was identified among 3343 of 16,693 patients with initial ESS; after matching, each cohort comprised 1574 patients (median age, 54 years; 40% female) with similar baseline health care costs (recurrent, $34,420; nonrecurrent, $33,737). At 12 months postindex, the recurrent cohort had higher HRU, including 36% and 51% more outpatient and emergency department visits, respectively (all P < .01). Mean health care costs were $9676 higher in the recurrent cohort ($24,039) relative to the nonrecurrent cohort ($14,363, P < .01). The mean cost difference between cohorts was driven by $8211 in additional outpatient costs, as well as $6062 in additional NP‐related outpatient costs, in the recurrent cohort (all P < .01).ConclusionNP recurrence is associated with a substantial economic burden, which appears to be driven by outpatient services.
Early detect left ventricular subclinical myocardial dysfunction in patients with systemic lupus erythematosus by a left ventricular pressure-strain loop
Authors: Zhong Xiao-Fang , Chen Li-Xin , Liu Li-Xiong , Peng Gui-Juan , Luo Shu-Yu , Liu Dong-Sheng , Xu Jin-Feng , Liu Ying-Ying 
Published: March 2022

Objective Noninvasive myocardial work (MW) is a new technology which is based on strain after considering the load influence on myocardial deformation. We aimed to investigate the feasibility of quantitatively assessing left ventricular myocardial work (LVMW) in patients with systemic lupus erythematosus (SLE) using a left ventricular pressure-strain loop (LVPSL). Methods 76 patients with SLE were included in the study (A), further divided into two subgroups according to the presence of lupus nephritis (LN). Global longitudinal strain (GLS), peak strain dispersion (PSD), global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE) were obtained. Results 1: Patients with SLE demonstrated a significantly reduced GWE and GLS compared with control group, GWW and PSD were increased, above changes were more pronounced in patients with LN. There was no significant difference in GWI and GCW. 2: Receiver operating characteristic (ROC) analysis demonstrated that GWE was the most powerful tool for detecting myocardial insufficiency early in SLE patients, and the area under the curve (AUC) was 0.804, and was superior to GLS (AUC = 0.707). GWE remains the best indicator of subclinical myocardial injury in patients with LN. The AUC was 0.910, and the best cutoff point was 96.5% (sensitivity 83.3%, specificity 73.3%). Conclusions LVPSL can be used to noninvasively assess changes in MW in patients with SLE. Noninvasive GWE is a more sensitive index than GLS to detect subclinical myocardial injury early in SLE patients. This is a potential valuable clinical tool to assist in the early-find myocardial damage.
Gender Disparities Among Craniofacial Surgeons
Authors: Lala Brittany M , Salvador Trina M , Wang Fei , Shah Jinesh , Ricci Joseph A 
Published: March 2022

To delineate career differences between genders of practicing plastic surgeons who have completed craniofacial fellowship given the known disparities in surgeons’ professional and personal lives and an already lengthy residency training, there is concern that less women may commit to further fellowship training. Craniofacial fellowship programs were contacted to identify graduates and an internet search was attempted where information was not available. Surgeon profiles and literature databases were used to obtain practice demographics and publications. Accredited fellowships were identified through the American Society of Craniofacial Surgeons directory. Program responses along with internet searches identified 201 graduates from 26 programs, of which 132 (66%) were men and 69 (34%) were women. On average, male graduates had 7.1 years in practice versus 6.6 years for females graduates ( P = .176). There were significant differences between average number of publications (24.7 publications for males vs 14.1 for females, P = .009) and academic practice (46% males vs 64% females, P = .018). A similar percentage of males and females held leadership positions (13% males vs 16%, P = .552). Despite similar years in practice, men had significantly higher publications while women were significantly more likely to practice in an academic setting. Females are increasing their representation in academia and leadership within the craniofacial community. However, efforts must still be directed at increasing exposure to craniofacial surgery and supporting research and leadership pursuits earlier on during their careers.
The Current Landscape of Oral Squamous Cell Carcinoma: A Comprehensive Analysis from ClinicalTrials.gov
Authors: Zou Zhaolei , Li Bin , Wen Shuqiong , Lin Dongjia , Hu Qiannan , Wang Zhi , Fang Juan 
Published: March 2022

Objective A better understanding of the current characteristics of clinical trials in oral squamous cell carcinoma (OSCC) is important to improve trial design and identify neglected areas of research. The objective is to summarize the current characteristics and publication status of OSCC trials registered on ClinicalTrials.gov. Methods The ClinicalTrials.gov database was searched on November 9, 2020, for trials containing the term “oral squamous cell carcinoma”. We assessed the characteristics of the included trials and searched the publication status of the primary completed trials by using PubMed and Google Scholar. Results Our search identified 325 studies for analysis, including 279 interventional (85.8%) and 46 observational (14.2%) studies. Interventional studies were mostly single-group (50.9%), single-center (57.0%), non-randomized (59.1%), open-label (81.4%), and early-phase (70.6%) trials. The vast majority of the studies (82.8%) focused on the treatment of OSCC. Chemotherapy (36.8%) was the most common treatment, followed by targeted therapy (15.2%) and immunotherapy (15.2%). Furthermore, 58.9% of the primary completed interventional studies were published by January 8, 2021, and the median time to publication was 48.0 months. Studies registered before this study began (HR = 1.69, 95% CI = 1.02–2.80, P = .040) and in phases 1/2 or 2 (HR = 2.10, 95% CI = 1.09–4.06, P = .026) were associated with an improved likelihood of publication. Conclusions OSCC clinical trials usually have small sample size and are open-label and non-randomized studies. Advanced OSCC and immunotherapy-oriented therapy are becoming the focus of current trials. Researchers should perform standardized registration and publish their results in a timely manner.
Health professionals’ practice to care cytotoxic drug handling and associated factors: The case of university of gondar specialized hospital
Authors: Simegn Wudneh , Dagnew Baye , Dagne Henok 
Published: March 2022

Background Health care professionals are potential to be in contact with cytotoxic drugs during their daily work activ­ities. The study aimed to assess the practice of health professionals to care for cytotoxic drugs and associated factors in the University of Gondar Specialized Hospital. Methods Cross-sectional study design was employed. EPI Info 7 was used for data entry and then exported into SPSS 20 for statistical analysis. Frequencies and mean with standard deviation were computed. Logistic regression had been performed to find out associated factors. Crude’ and adjusted Odds’ ratio with 95% uncertainty interval was done. Variables with a p < 0.05 were declared as significant factors for practice of cytotoxic drug handling. Results The study used four-hundred and twelve health professionals took part in the study with 97.4% response rate. The mean age of study participants was 29.9 years ranging from 20–60 years and twenty (53.4%) participants were males. One hundred and fifty-five (37.6%) health professionals had good cytotoxic drug handling practice. Attending an average of 4–9 patients per day (AOR = 2.12, 95% CI: 1.05, 4.22), Medium work stress (AOR = 2.01, 95% CI: 1.04, 3.90), availability of cytotoxic drug handling manual (AOR = 2.51: 95% CI: 1.22, 5.12), and good knowledge (AOR = 4.09, 95% CI: 2.35, 7.11) were significantly associated with cytotoxic drug handling practice. Conclusion The practice of cytotoxic drug handling care was low. It demands the engagement of the health sector to avert such inadequate practice and has to focus on delivering knowledge and logistics for the practice of cytotoxic drug handling.
Non-arteritic anterior ischemic optic neuropathy after uneventful delivery in a healthy woman
Authors: Montolío-Marzo Santiago , Gallego-Pinazo Roberto , Dolz-Marco Rosa , Lanzagorta-Aresti Aitor , Pérez-López Marta 
Published: March 2022

Introduction Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of optic nerve swelling and optic neuropathy in adults over 50 years of age. It has been rarely reported during pregnancy, mostly related to systemic and ocular predisposing conditions. Case Report We report the case of a 44 years-old healthy female with no previous remarkable clinical history. She had in vitro fertilisation treatment to get pregnant. 18 days after uneventful cesarean section she referred sudden painless vision loss in her right eye (RE), denser inferiorly, with concurrent optic disc edema and relative afferent pupillary defect. Steroid intravenous treatment during the acute episode showed no improvement. Our patient showed normal magnetic resonance imaging (MRI), blood test, autoimmune disease biomarkers, infectious serology and inflammatory markers. She was diagnosed of RE NAION. After one year follow-up visual field defect remains stable. Conclusion As far as we know this is the first report of NAION after in vitro fertilisation, uneventful pregnancy and cesarean section showing no systemic or ocular risk factors other than a small cup to disc ratio. Hemodynamic and hormonal changes during late pregnancy and uneventful cesarean section can trigger an episode of NAION in a healthy young woman.
Study of vitamin D penetration in the human aqueous after topical administration
Authors: Lorusso Massimo , Micelli Ferrari Luisa , Cicinelli Maria Vittoria , Ciani Saba , Ceci Edmondo 
Published: March 2022

Purpose this study was designed to measure the concentration of Vitamin D in the aqueous and to investigate if its topical application can increase quantities in aqueous humor. Methods 29 patients scheduled for cataract surgery were divided into two groups. Group 1 was used as a control group, in group 2 patients were instructed to instill one drop of vitamin D eye drops three times daily 10 days before surgery .Aqueous humor was collected with a 30-gauge needle immediately before surgery. Vitamin D concentrations were analyzed by liquid chromatography tandem mass spectrometry. Results Aqueous humor (AH) samples in both groups had small but detectable vitamin D levels. In the AH concentrations of vitamin D were, respectively, 2.1ng/mL 土0.4 in group 1 and 2.1ng/mL土0.3 in group 2(P = 0.9). Conclusion Our study confirmed the presence of vitamin D in AH. No significant difference of vitamin D concentration in AH was observed between the treatment and control group.
Last chance to travel or safety first? The influence of exposure to natural hazards and coping capacities on tourism consumption
Authors: Nguyen Canh P 
Published: March 2022

The literature shows that natural disasters adversely affect international (arrivals) tourism. However, there seems to have been a lack of consideration of the dynamics of domestic and outbound (departure) tourism consumption in respect of natural hazards. To address this gap, this study uses a unique dataset of exposure to natural hazards and coping capacities for a global sample of 145 economies from 2011 to 2019 to examine the influence on domestic, outbound and total tourism spending. Exposure appears to have inverted U-shaped relationships with domestic and total tourism spending, and a U-shaped relationship with outbound spending. Coping capacities, in contrast, have U-shaped relationships with domestic and total tourism spending, with an inverted U-shaped relationship with outbound spending. Lastly, the analyses for four income groups and seven regions show some heteroscedasticity. The findings suggest that governments should build coping capacities for the recovery of tourism after disaster events. JEL codes: Z32, Z38, Q01, Q54
Src-related thrombocytopenia: a fine line between a megakaryocyte dysfunction and an immune-mediated disease
Authors: Palma-Barqueros Verónica , Revilla Nuria , Zaninetti Carlo , Galera Ana María , Sánchez-Fuentes Ana , Zámora-Cánovas Ana , Bohdan Natalia , Padilla José , Marín-Quilez Ana , Rodriguez-Alen Agustín , Fuster José Luis , Greinacher Andreas , Vicente Vicente , Bastida José María , Rivera José , Lozano María Luisa 
Published: March 2022

AbstractSrc-related thrombocytopenia (SRC-RT) is a rare autosomal dominant, inherited platelet disorder resulting from the p.E527K heterozygous germline gain-of-function variant of Src. To date, genetic diagnosis of the disease has only been reported in 7 patients from 3 unrelated families. The clinical features ranged from isolated thrombocytopenia to complex syndromic manifestations characterized by thrombocytopenia, bleeding, myelofibrosis, splenomegaly, and bone disease. We report a new 3-generation kindred with the Src p.E527K variant. Patients presented with rather variable platelet counts (38-139 × 109/L), mildly impaired platelet function, &gt;15% immature platelet fraction, and with a significant proportion of large-giant platelets. Four adults from the family were diagnosed with immune thrombocytopenia (ITP) and underwent splenectomy, achieving sustained platelet counts &gt;75 × 109/L for several years; increases in platelet counts were also observed after corticosteroid therapy. Four of 7 Src p.E527K variant carriers showed immune defects and recurrent infections. In addition, a range of neurological symptoms, from specific language impairment to epilepsy, was seen in some family members. Patient platelets exhibited constitutive Src, Bruton tyrosine kinase, and phospholipase Cγ2 activation, and after stimulating CD19 cells by crosslinking surface immunoglobulin M, phosphorylated extracellular signal-regulated kinase (ERK) was significantly increased in B cells from individuals carrying the Src p.E527K substitution. In summary, in addition to causing impaired platelet production, SRC-RT may associate immune dysregulation and increased platelet consumption. In families in whom several members are responsive to ITP-directed therapies, an underlying Src p.E527K variant should be excluded.
Effect of additional cytogenetic abnormalities on survival in arsenic trioxide-treated acute promyelocytic leukemia
Authors: Epstein-Peterson Zachary D. , Derkach Andriy , Geyer Susan , Mrózek Krzysztof , Kohlschmidt Jessica , Park Jae H. , Rajeeve Sridevi , Stein Eytan M. , Zhang Yanming , Iland Harry , Campbell Lynda J. , Larson Richard A. , Poiré Xavier , Powell Bayard L. , Stock Wendy , Stone Richard M. , Tallman Martin S. 
Published: March 2022

AbstractFrontline arsenic trioxide (ATO)–based treatment regimens achieve high rates of long-term relapse-free survival in treating acute promyelocytic leukemia (APL) and form the current standard of care. Refining prognostic estimates for newly diagnosed patients treated with ATO-containing regimens remains important in continuing to improve outcomes and identify patients who achieve suboptimal outcomes. We performed a pooled analysis of exclusively ATO-treated patients at a single academic institution and from the ALLG APML4 and Alliance C9710 studies to determine the prognostic importance of additional cytogenetic abnormalities and/or complex karyotype. We demonstrated inferior event-free survival for patients harboring complex karyotype (hazard ratio [HR], 3.74; 95% confidence interval [CI], 1.63-8.56; P = .002), but not for patients harboring additional cytogenetic abnormalities (HR, 2.13; 95% CI, 0.78-5.82; P = .142). These data support a role for full karyotypic analysis of all patients with APL and indicate a need for novel treatment strategies to overcome the adverse effect of APL harboring complex karyotype.
Developing a dynamic simulation model to support the nationwide implementation of whole genome sequencing in lung cancer
Authors: van de Ven Michiel , IJzerman Maarten , Retèl Valesca , van Harten Wim , Koffijberg Hendrik 
Published: March 2022

Abstract
Background
This study shows how dynamic simulation modeling can be applied in the context of the nationwide implementation of Whole Genome Sequencing (WGS) for non-small cell lung cancer (NSCLC) to inform organizational decisions regarding the use of complex and disruptive health technologies and how these decisions affect their potential value.

Methods
Using the case of the nationwide implementation of WGS into clinical practice in lung cancer in the Dutch healthcare system, we developed a simulation model to show that including service delivery features across the diagnostic pathway can provide essential insight into the affordability and accessibility of care at the systems level. The model was implemented as a hybrid Agent-Based Model and Discrete-Event Simulation model in AnyLogic and included 78 hospital agents, 7 molecular tumor board agents, 1 WGS facility agent, and 5313 patient agents each year in simulation time.

Results
The model included patient and provider heterogeneity, including referral patterns, capacity constraints, and diagnostic workflows. Patient preference and adoption by healthcare professionals were also modeled. The model was used to analyze a scenario in which only academic hospitals have implemented WGS. To prevent delays in the diagnostic pathway, the capacity to sequence at least 1600 biopsies yearly should be present. There is a two-fold increase in mean diagnostic pathway duration between no patients referred or all patients referred for further diagnostics.

Conclusions
The systems model can complement conventional health economic evaluations to investigate how the organization of the workflow can influence the actual use and impact of WGS. Insufficient capacity to provide WGS and referral patterns can substantially impact the duration of the diagnostic pathway and thus should be considered in the implementation of WGS.
Clinical characteristics and risk factors of Aeromonas bloodstream infections in patients with hematological diseases
Authors: Xu Chunhui , Lin Qingsong , Zhao Yuanqi , Zhu Guoqing , Jiang Erlie , Li Shangzhu , Mi Yingchang , Zheng Yizhou , Zhang Fengkui , Zhu Xiaofan , Xiao Zhijian , Han Mingzhe , Wang Jianxiang , Feng Sizhou 
Published: March 2022

Abstract
Background
To analyze the clinical features, risk factors and outcomes of Aeromonas bloodstream infections (BSIs) in patients with hematological diseases to establish an effective optimal therapy against it.

Methods
A retrospective study was performed by reviewing medical records of patients admitted to a tertiary blood disease hospital in China. Patients with hematological diseases who suffered from Aeromonas bacteremia during January 2002 to December 2020 were enrolled in this study.

Results
A total of 63 patients who developed Aeromonas bacteremia were enrolled in the study, and 91.9% of patients were neutropenic at the onset of BSIs. The major complications were skin and soft tissue infection (SSTI) (22.2%), followed by gastroenteritis (19.0%) and pneumonia (14.3%). High carbapenem resistance rates (70.8% for imipenem, 71.4% for meropenem) were note among the cases. Furthermore, Aeromonas strains isolated from five individuals developed resistance to quinolone, β-lactams and tigecycline during the therapy. The 30-day mortality rate was 15.9%, while bacteremia with SSTI showed a much worse prognosis, with 50.0% (7/14) of the patients dying within 30 days of initiating the therapy. In the multivariate analysis, SSTI (OR = 28.72; 95% CI, 1.50–551.30; P = 0.026) and shock (OR = 47.58; 95% CI,1.06–2126.80; P = 0.046) were independent risk factors for mortality.

Conclusions
Aeromonas bacteremia usually occurred in patients with neutropenic status, and patients with SSTIs were more likely to show a worse prognosis. Carbapenems should be avoided in patients with Aeromonas BSIs and SSTIs given high resistance rate.