bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptation of a Problem-solving Program (Friendship Bench) to Treat Common Mental Disorders Among People Living With HIV and AIDS and on Methadone Maintenance Treatment in Vietnam: Formative Study
Authors: Tran Ha V , Nong Ha T T , Tran Thuy T T , Filipowicz Teresa R , Landrum Kelsey R , Pence Brian W , Le Giang M , Nguyen Minh X , Chibanda Dixon , Verhey Ruth , Go Vivian F , Ho Hien T , Gaynes Bradley N 
Published: June 2022

Background
The prevalence of common mental disorders (CMDs) among people living with HIV and people who inject drugs is high worldwide and in Vietnam. However, few evidence-informed CMD programs for people living with HIV who inject drugs have been adapted for use in Vietnam. We adapted the Friendship Bench (FB), a problem-solving therapy (PST)–based program that was successfully implemented among patients with CMDs in primary health settings in Zimbabwe and Malawi for use among people living with HIV on methadone maintenance treatment (MMT) with CMDs in Hanoi, Vietnam.

Objective
This study aimed to describe the adaptation process with a detailed presentation of 4 phases from the third (adaptation) to the sixth (integration) of the Assessment-Decision-Adaptation-Production-Topical Experts-Integration-Training-Testing (ADAPT-ITT) framework.

Methods
The adaptation phase followed a qualitative study design to explore symptoms of CMDs, facilitators, and barriers to conducting FB for people living with HIV on MMT in Vietnam, and patient, provider, and caretaker concerns about FB. In the production phase, we revised the original program manual and developed illustrated PST cases. In the topical expert and integration phases, 2 investigators (BNG and BWP) and 3 subject matter experts (RV, DC, and GML) reviewed the manual, with reviewer comments incorporated in the final, revised manual to be used in the training. The draft program will be used in the training and testing phases.

Results
The study was methodologically aligned with the ADAPT-ITT goals as we chose a proven, effective program for adaptation. Insights from the adaptation phase addressed the who, where, when, and how of FB program implementation in the MMT clinics. The ADAPT-ITT framework guided the appropriate adaptation of the program manual while maintaining the core components of the PST of the original program throughout counseling techniques in all program sessions. The deliverable of this study was an adapted FB manual to be used for training and piloting to make a final program manual.

Conclusions
This study successfully illustrated the process of operationalizing the ADAPT-ITT framework to adapt a mental health program in Vietnam. This study selected and culturally adapted an evidence-informed PST program to improve CMDs among people living with HIV on MMT in Vietnam. This adapted program has the potential to effectively address CMDs among people living with HIV on MMT in Vietnam.

Trial Registration
ClinicalTrials.gov NCT04790201; https://clinicaltrials.gov/ct2/show/NCT04790201
Dopamine negatively regulates insulin secretion through activation of D1-D2 receptor heteromer
Authors: Uefune Fumiya , Aonishi Toru , Kitaguchi Tetsuya , Takahashi Harumi , Seino Susumu , Sakano Daisuke , Kume Shoen 
Published: June 2022

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<p>There is increasing evidence that dopamine (DA) functions as a negative regulator of glucose-stimulated insulin secretion (GSIS); however, the underlying molecular mechanism remains unknown. Using total internal reflection fluorescence microscopy, we monitored insulin granule exocytosis in primary islet cells to dissect the effect of DA. We found that D1 receptor antagonists rescued the DA-mediated inhibition of glucose-stimulated calcium (Ca2+) flux, thereby suggesting a role of D1 in the DA-mediated inhibition of insulin secretion. Overexpression of D2 but not D1 alone exerted an inhibitory and toxic effect that abolished the glucose-stimulated Ca2+ influx and insulin secretion in beta-cells. Proximity ligation and western blot assays revealed that D1 and D2 form heteromers in beta-cells. Treatment with a D1-D2 heteromer agonist, SKF83959, transiently inhibited glucose-induced Ca2+ influx and insulin granule exocytosis. Co-expression of D1 and D2 enabled beta-cells to bypass the toxic effect of D2 overexpression. DA transiently inhibited glucose-stimulated Ca2+ flux and insulin exocytosis by activating the D1-D2 heteromer. We conclude that D1 protects beta-cells from the harmful effects of DA by modulating D2 signaling. The finding will contribute to our understanding of the DA signaling in regulating insulin secretion and improve methods for preventing and treating diabetes.</p>
Carbonyl Post-Translational Modification Associated with Early Onset Type 1 Diabetes Autoimmunity
Authors: Yang Mei-Ling , Connolly Sean E. , Gee Renelle , Lam TuKiet T. , Kanyo Jean , Peng Jian , Guyer Perrin , Syed Farooq , Tse Hubert M. , Clarke Steven G. , Clarke Catherine F. , James Eddie A. , Speake Cate , Evans-Molina Carmella , Arvan Peter , Herold Kevan C. , Wen Li , Mamula Mark J. 
Published: June 2022

<p>Inflammation and oxidative stress in pancreatic islets amplify the appearance of various post-translational modifications (PTMs) to self-proteins. Herein, we identified a select group of carbonylated islet proteins arising before the onset of hyperglycemia in non-obese diabetic mice. Of interest, we identified carbonyl modification of the prolyl-4-hydroxylase beta subunit (P4Hb) that is responsible for proinsulin folding and trafficking as an autoantigen in both human and murine type 1 diabetes. We found the carbonylated P4Hb is amplified in stressed islets coincident with decreased glucose-stimulated insulin secretion and altered proinsulin to insulin ratios. Autoantibodies against P4Hb were detected in prediabetic NOD mice and in early human type 1 diabetes prior to the onset of anti-insulin autoimmunity. Moreover, we identify autoreactive CD4+ T cell responses toward carbonyl-P4Hb epitopes in the circulation of patients with type 1 diabetes. Our studies provide mechanistic insight into the pathways of proinsulin metabolism and in creating autoantigenic forms of insulin in type 1 diabetes. </p>
STRUKTUR DAN FUNGSI GORDANG LIMA DALAM KEBUDAYAAN MASAYARAKAT MANDAILING DI PAKANTAN KABUPATEN MANDAILING NATAL: KONTINUITAS DAN PERUBAHAN
Authors: Lubis Mahda Reni , Tarigan Kumalo , Suroso Panji 
Published: June 2022

Tujuan penelitian ini adalah untuk mengetahui struktur, fungsi dan kontiunitas pada kesenian Gordang Lima di Pakantan. Penelitian ini mengkaji struktur, dan melihat kontiunitas dan perubahan Gordang Lima. Teori yang dipakai untuk mengupas permasalahan dalam penelitian ini adalah teori struktur bentuk musik, fungsi musik, kontinuitas dan perubahan. Hasil dari penelitian ini adalah struktur bentuk musik pada Gordang Lima versi baru dan versi lama, sarune gordang lima versi baru penggunaan nada dasar yang digunakan adalah D = do mengikuti nada dasar mayor melodi sarune. Sedangkan nada dasar sarune versi lama ada pada As = do. Kedua, penggunaan gordang lima pada masyarakat Mandailing memiliki beberapa fungsi selain dari ritual memaggil roh, yaitu antara lain: Kedua kontinuitas dan perubahan yang terjadi dalam ritual paturun sibaso pada masyarakat Mandailing dalam bentuk musik, instrumen, dan pertunjukkan akan berlangsung sampai masa yang tidak diketahui melihat sejauh mana masyarakat menilai bahwa ritual ini penting atau tidak pentingnya dilakukan. Hal-hal yang mengalami keberlanjutan sampai sakarang adalah alat musik yang dipakai dan bentuk ritem pada gordang jangat dan patolu.
Technology and quality of phyto-candies from Japanese kelp
Authors: Dement'eva Natal'ya , Boytsova Tatiana 
Published: June 2022

The developed technology of producing phyto-candies from Japanese kelp provides the high organoleptic characteristics, nutritional and biological values of the products. The phyto-candy formulations contain 60% kelp, 14% honey, dried fruits (apricots, prunes, dates, mangoes). Preliminary kelp heat treatment, including threefold short-term kelp boiling sessions at 85-95 °C, provides a dense but not rigid kelp structure. Adding 2% of citric acid at the second boiling session helps to remove the pronounced taste and smell of algae. Under processing kelp slightly loses moisture. It has been found that fresh kelp contains 94.5% of water before treatment; after treatment the amount
of water in it is 90.6-91.3%. In pretreatment kelp slightly loses the mineral substances, the amount of which after processing makes 1.31%. Under heat treatment the amount of mannitol in luminaria decreases almost twice, nevertheless 7.74% of mannitol remains. Adding a citric acid to the boiling water during kelp processing causes the increase
of alginic acids in it. In the fresh kelp the alginic acid content was 27.44%, and after processing - 33.87%. The relative biological value of phyto-candies produced from Japanese kelp varies within 70.8-78.2% depending on the formulation. The maximum increase in Tetrahymena pyriformis infusoria and a higher relative biological value were observed in phyto-candies prepared according to the formulations including dried apricots and prunes. When storing phyto-sweets from Japanese kelp at 0-6 °C and humidity of 75% during 9 months, the number of mesophilic aerobic and facultative anaerobic microorganisms did not exceed the maximum permissible norms and varied within 0.1 ∙ 101 CFU/g at the beginning of storage - 4.9 ∙ 104 CFU/g at the end of the storage period. Bacteria of the E. coli group, S. aureus, mold, or yeast were not detected.
Liraglutyd – jak osiągnąć cele terapeutyczne – miesiąc, rok czy terapia przewlekła?
Authors: Walczak Marta 
Published: June 2022

Podstawową zasadą leczenia choroby otyłościowej jest leczenie kompleksowe. Cele terapii powinny być indywidualnie dobierane do pacjenta i zależeć przede wszystkim od chorób współistniejących oraz ewentualnie występujących powikłań. Analogicznie do innych chorób przewlekłych, m.in.: nadciśnienia tętniczego, cukrzycy typu 2, przewlekłych zespołów wieńcowych, strategia leczenia choroby otyłościowej powinna obejmować metody niefarmakologiczne, farmakoterapię oraz, w razie braku skuteczności, leczenie operacyjne. Rekomendowany czas trwania farmakoterapii wynosi min. 12 miesięcy. Liraglutyd działa centralnie na neurony proopiomelanokortyny (POMC)/CART, zwiększając uczucie sytości oraz zmniejszając głód, z przejściowym efektem zmniejszającym opróżnianie żołądka, dzięki czemu kontroluje łaknienie.
Spośród wielu korzystnych cech liraglutydu do udokumentowanych i szczególnie ważnych z klinicznego punktu widzenia zalicza się: pozytywny wpływ na zaburzenia gospodarki węglowodanowej, działanie kardioprotekcyjne na zmniejszenie ryzyka zgonu z przyczyn sercowo-naczyniowych, zawału lub udaru niezakończonego zgonem oraz zmniejszenie ciśnienia skurczowego u osób z nieprawidłową glikemią bądź bez niej w stosunku do placebo.
Przypadki kliniczne pacjentów leczonych tadalafilem oraz solifenacyną
Authors: Sapilak Bartosz J. 
Published: June 2022

W artykule przedstawiono zasady terapii dwoma lekami urologicznymi – tadalafilem i solifenacyną. Zaprezentowano również przypadki kliniczne omawiające ich praktyczne zastosowanie. Pierwszy wykorzystywany jest głównie w leczeniu zaburzeń wzwodu i przerostu prostaty, drugi w terapii naglącego nietrzymania moczu, częstomoczu i parcia naglącego. Działanie tadalafilu opiera się na selektywnej i odwracalnej inhibicji specyficznej fosfodiesterazy cGMP typu 5. Zahamowanie aktywności enzymu przez tadalafil prowadzi do hamowania rozpadu i nasilenia działania cGMP w ciałach jamistych prącia, co przedłuża relaksację mięśni gładkich i powoduje napływ krwi do tkanek członka, a tym samym pomaga uzyskać i utrzymać wzwód. W tym wskazaniu lek stosujemy doraźnie, nie częściej niż 1–2 razy w tygodniu. W terapii łagodnego przerostu stercza leczenie opiera się na mniejszych dawkach tadalafilu, ale przyjmowanych codziennie.
Rozpoznanie zespołu pęcherza nadreaktywnego wymaga przede wszystkim zebrania wywiadu lekarskiego, wykonanie badania urodynamicznego nie jest konieczne. W terapii stosujemy leki antycholinergiczne, jednym z nich jest solifenacyna. Lek charakteryzuje wysokie powinowactwo do znajdujących się w pęcherzu i cewce moczowej receptorów muskarynowych M3 i M, cecha ta leży u podłoża dobrej tolerancji solifenacyny przez chorych. Rozpoznanie i leczenie obu omawianych zaburzeń leży w kompetencjach lekarzy rodzinnych, mają oni pełne prawo do diagnozowania problemu, ustalenia rozpoznania i inicjacji adekwatnej terapii.
Clinicopathological findings in and prognostic factors for domestic rabbits with liver lobe torsion: 82 cases (2010–2020)
Authors: Ozawa Sarah M. , Graham Jennifer E. , Guzman David Sanchez-Migallon , Tucker Samuel M. , Petritz Olivia A. , Sullivan Patrick , Robertson James B. , Hawkins Michelle G. 
Published: June 2022

Abstract

OBJECTIVE
To document clinicopathologic findings in domestic rabbits with liver lobe torsion and identify prognostic factors.

ANIMALS
82 rabbits.

PROCEDURE
Medical records of 4 institutions were reviewed to identify rabbits with an antemortem diagnosis of liver lobe torsion that were examined between 2010 and 2020.

RESULTS
The prevalence of liver lobe torsion was 0.7% (82/11,402). In all 82 rabbits, the diagnosis was made by means of abdominal ultrasonography. Fifty (60.1%) rabbits underwent liver lobectomy, 23 (28%) received medical treatment alone, and 9 (10.9%) were euthanized or died on presentation. Overall, 32 (39%) rabbits died within 7 days of initial presentation and 50 (61%) survived. Seven-day survival rate did not differ significantly between medical treatment alone and surgical treatment. However, median survival time following medical treatment (530 days) was shorter than that following surgical treatment (1,452 days). Six of 14 rabbits had evidence of systemic inflammatory disease on necropsy. Rabbits with right liver lobe torsion were less likely to survive for 7 days than were those with caudate torsions (P = 0.046; OR, 3.27; 95% CI, 1.04 to 11.3). Rabbits with moderate to severe anemia were less likely to survive for 7 days than were rabbits that were not anemic or had mild anemia (P = 0.006; OR, 4.41; 95% CI, 1.55 to 12.51). Other factors associated with a decreased 7-day survival rate were high heart rate at admission (P = 0.013) and additional days without defecation after admission (P < 0.001). Use of tramadol was associated with an increased survival rate (P = 0.018).

CLINICAL RELEVANCE
The prognosis for rabbits with liver lobe torsions was more guarded than previously described. Rabbits that underwent liver lobectomy had a longer median survival time than did rabbits that only received medical treatment.
Effect of pasteurization on melatonin concentration in human breast milk
Authors: Chrustek Agnieszka , Sinkiewicz-Darol Elena , Lampka Magdalena , Olszewska-Słonina Dorota , Sperkowska Beata , Linowiecka Kinga 
Published: June 2022

Abstract

Introduction
Women who have problems with lactation can use human milk banks. Mainly this human milk is provided to premature babies and sick newborns. Human milk is the most suitable food for newborns and infants, recommended by WHO (World Health Organization). Human milk has anti-inflammatory, anti-infective, and anti-allergic properties, and also works for immunomodulation. Melatonin has a special, underestimated importance in the composition of breast milk. It is a hormone that has many body functions and, for several decades, its antioxidant potential has been increasingly talked about.
The aim of the study was to examine the effect of Holder pasteurization on melatonin concentration in human milk.

Materials and Methods
18 samples of human milk from donors from the human milk bank were used for the analysis. Melatonin concentration before and after pasteurization was determined by ELISA. In addition, the nutritional content composition of milk was analyzed using MIRIS Human Milk Analyzer and correlations examined.

Results
Melatonin concentration in human milk before pasteurization was 0.65–26.24 pg/mL (Me=9.58, IQR=12.72), while after pasteurization 0.80–29.58 pg/mL (Me=9.98, IQR=11.26). There was a positive correlation between melatonin concentration before and after pasteurization (r=0.797, p<0.001).

Conclusions
The Holder pasteurization process does not affect the concentration of melatonin in milk samples, which may be a recommendation for human milk banks.
GRZYBY ENDOFITYCZNE W ROLI POTENCJALNYCH PRODUCENTÓW ZWIĄZKÓW PRZECIWNOWOTWOROWYCH
Authors: Getinger-Panek Agnieszka , Bednarek Ilona 
Published: June 2022

Streszczenie
Główną rolę w chemioterapii raka od ponad 50 lat, stanowią leki pochodzące w większości ze źródeł naturalnych. Przeciwko licznym dolegliwościom od stuleci rośliny służyły jako źródło związków bioaktywnych. Jednak to nie same rośliny, a mikroorganizmy z nimi związane oferują materiał i produkty o wysokim potencjale terapeutycznym. Endofity to organizmy, które kolonizują wewnętrzne tkanki roślin bez wywoływania objawów chorobowych. Stanowią endosymbiotyczną grupę drobnoustrojów, będących źródłem nowatorskich produktów naturalnych do wykorzystania we współczesnym przemyśle, rolnictwie oraz medycynie wykazując potencjalne właś ciwości terapeutyczne, w tym przeciwnowotworowe oraz przeciwdrobnoustrojowe, a także przeciwzapalne i antyoksydacyjne. Grzyby endofityczne stanowią bogate źródło bioaktywnych metabolitów, którymi można manipulować w celu uzyskania pożądanych, nowych analogów wykorzystywanych w chemioterapii, w tym: taksol, kamptotecyna, podofilotoksyna, winblastyna, winkrystyna, cytochalazyny i szereg innych. W tym przeglądzie podano przykłady produkcji związków przeciwnowotworowych przez grzyby endofityczne opublikowane od 2015 roku.
Possibilities of geoinformational analysis for assessment of the state and directions of development of geodetic support of the territory of Ukraine
Authors: Bespalko Ruslan , Kazimir Ivan , Hutsul Taras 
Published: June 2022

Abstract
Topographic, geodetic and cartographic activities are one of the main activities for the effective development of the economy, science of strengthening national security and defense. It is a set of management, production, scientific and educational activities for the storage and communication to users of geodetic and cartographic information and data. The article considers one of the segments of this activity – the state of geodetic support of the territory of Ukraine and its assessment according to official data on the possibility of creating topographic maps and plans of scale 1:25 000 – 1:2000 in compliance with applicable regulations. To carry out the assessment, around the points of the State Geodetic Network of Ukraine (DGM) buffer zones of radii of circles of standard sizes were constructed, zoning of the territory with Thissen-Voronoi polygons and covering of the territory in the form of a hexagonal grid were done by means of ArcGIS. The results of the current assessment as of 2022 conducted by three methods are summarized in the table in terms of oblasts of Ukraine. The data obtained are compared to the previous assessment conducted five years ago. Changes in the state of geodetic support have been identified and their objective reasons explained. The advantages and disadvantages of each of the proposed methods of geoinformation analysis of the assessment of the state of geodetic support of the territories are given. It is established that the combination of different methods will allow to use the existing points of DGM with greater efficiency and to substantiate the priority places for further development of the network. The complex of scientific and applied works related to the modernization of the state geodetic network will allow to quickly and locally develop a network based on satellite and computer technologies and create and present digital cartographic information at the modern scientific and technical level in accordance with current needs.
Removal of Cd, Cu, Ni, and Pb from Nanoscale Zero-Valent Iron Amended Soil Using 0.1 M Acetic Acid Solution
Authors: Danila Vaidotas , Januševičius Tomas 
Published: June 2022

Abstract
The purpose of the study was to evaluate the possibility of removing heavy metal cations from single-metal spiked soil samples, which were pretreated with nanoscale zero-valent iron (nZVI) particles. Sandy soil was artificially contaminated with copper (Cu), cadmium (Cd), nickel (Ni), and lead (Pb). Contaminated soil samples were amended with different doses of nZVI (0.35, 0.70 and 1.05 %). A sequential extraction method was used to determine the fractionation of heavy metal cations in the control and nZVI amended soil samples. A solution of 0.1 M acetic acid (pH 3.0) was used to investigate the removal of heavy metals from control and nZVI-amended soil samples. The results showed that nZVI reduced the amount of metals in the exchangeable form and increased the proportion of these metals associated with amorphous iron (Fe) oxides. The results also showed that the removal efficiencies of heavy metals increased with increasing nZVI dose, that is, from 46.9 %, 5.77 %, 33.5 %, and 2.70 % to 55.9 %, 12.3 %, 46.2 %, and 3.79 % for Cd, Cu, Ni, and Pb, respectively. The study indicated that the application of nZVI in soil could be beneficial for subsequent removal of heavy metals from soil using 0.1 M acetic acid solution.
TEKNOLOGI MESIN PRODUKSI GULA JAHE BAGI INDUSTRI RUMAH TANGGA JAHE INSTAN â€MERAPI MANTAPâ€ DI DUSUN KINAHREJO YOGYAKARTA
Authors: Ngatirah Ngatirah , Dewi Christina wahyu Ari 
Published: June 2022

Program Kemitraan Masyarakat (PKM) dilaksanakan dengan mitra industri rumah tangga (IRT) Jahe Instan â€œMerapi Mantap" di Dusun Kinahrejo, Umbulharjo, Cangkringan, Sleman. Salah satu permasalahan yang dihadapi mitra adalah kapasitas produksiÂ gula jahe yang relatif rendah dan belum bisa memenuhi permintaan pasar, proses produksi masih secara manual dengan peralatan sederhana. Tujuan PKM ini adalah membuat rancang bangun dan pelatihan penggunaan mesin produksi gula jahe bagi IRT Jahe Instan â€œMerapi Mantap" sehingga kapasitas an efisiensi produksi dapat ditingkatkan. Metode yang dilakukan adalah perancangan dan pembuatan peralatan Mesin Produksi gula jahe (wajan berpengaduk dan cetakan untuk produk Kristal) serta pelatihan penggunaan mesin produksi. Hasil kegiatan PKM ini adalah adanya introduksi mesin pembuat gula jahe proses produksi gula jahe dengan kapasitas 50 kg/jam untuk sekali proses serta alat pencetak gula jahe Kristal. Dampak kegiatan ini adalah adanya peningkatan kapasitas produksi gula jahe dan gula kristal dari rata 50 kg/minggu menjadi minimal 100 kg/minggu ( meningkat minimal 2 kali lipat) disertai dengan efisiensi tenaga dan waktu dalam mengolah gula jahe dan gula Kristal yang tadinya 50 kg-100 kg/minggu dilaksanakan dengan 10 kali proses dengan waktu 2-3 hari menjadi 1 hari proses. Bentuk gula jahe yang tadinya tidak beraturan menjadi berbentuk bulat dengan berat yang seragam. Kesimpulan program PKM ini adalah terdapat peningkatan pemahaman dan ketrampilan mitra dalam penggunaan peralatan produksi gula jahe. Mutu gula jahe yang tadinya tidak beeraturan menjadi seragam. penggunaan mesin produksi gula jahe dapat meningkatkan efisiensi dan kapasitas produksi gula jahe