bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competition between form-related words in bilingual sentence reading: Effects of language proficiency
Authors: Pélissier Maud , Haugland Dag , Handeland Bjørn , Urland Beatrice Zitong , Wetterlin Allison , Wheeldon Linda , Frisson Steven 
Published: October 2022

AbstractSentence reading involves constant competition between lexical candidates. Previous research with monolinguals has shown that the neighbours of a read word are inhibited, making their retrieval as a subsequent target more difficult, but the duration of this interference may depend on reading skills. In this study, we examined neighbour priming effects in sentence reading among proficient Norwegian–English bilinguals reading in their L2. We investigated the effects of the distance between prime and target (short vs. long) and the nature of the overlap between the two words (beginning or end), and related these to differences in individual cognitive skills. Our results replicated the inhibition effects found in monolinguals, albeit slightly delayed. Interference between form-related words was affected by the L2 reading skills and, crucially, by the phonological decoding abilities of the bilingual reader. We discuss the results in light of competition models of bilingual reading as well as episodic memory accounts.
Evaluation of the Plasticity of Novel Regulatory Cells—Telocytes—in the Gonad of the Male Chinese Soft-Shelled Turtle (Pelodiscus sinensis) Associated with Seasonal Reproductive Activity
Authors: Meng Xiangfei , Ding Baitao , Zhu Zhaoxuan , Ma Qianhui , Wang Qi , Feng Yongchao , Liu Yue , Wang Jia , Yang Ping 
Published: October 2022

Abstract
Telocyte (TC)—a new type of interstitial cell with long telopodes, can form cellular junctions with various tissues or cells to participate in the regulation of multitudes of physiological activities and diseases. This study aimed to characterize the morphology, molecular features, and potential functions of hormone regulation in Chinese soft-shelled turtle (Pelodiscus sinensis) testis TCs at different reproductive stages by histological evaluation, immunohistochemistry (IHC), immunofluorescence (IF), and transmission electron microscopy. During hibernation, TCs were widely distributed in the interstitial tissue. In contrast, during reproductive activity, TCs were noted to be in close proximity with peritubular myoid cells surrounding the seminiferous tubule. Moreover, formed cell–cell junctions were observed between TCs and PTMs. The results of IHC and IF showed that the immunophenotype of testicular TCs in hibernating Chinese soft-shelled turtles is CD34+Vimentin−, while the reproductive telopodes (Tps) show low expression of vimentin. The androgen receptor is expressed in Tps of TCs of testis during hibernation. Our results showed also that TCs in seasonal breeding animals regulate the activity of neighboring cells by releasing extracellular microvesicles (EXMVs), thus influencing the activity of spermatogenesis and steroidogenesis. Consideration of our novel and interesting results indicate that the whole area warrants further research.
From invisibility to positive legal protection: The drafting of Article 11 of the Convention on the Rights of Persons with Disabilities
Authors: Begg Andrew 
Published: October 2022

AbstractInitial drafts of the Convention on the Rights of Persons with Disabilities (CRPD) did not include any significant reference to the obligations of States to protect their citizens with disabilities during armed conflict or other emergency situations; international documents dealing with disability up until that point had not considered persons with disabilities as rights holders during armed conflict either. But early in the negotiations for the CRPD, disabled persons’ organizations made it clear that they wanted to see the protections of the Convention extend to times of risk, emergency and armed conflict.This study focuses on Article 11 of the CRPD. The negotiating history of Article 11 demonstrates that although there were some disagreements over the scope of the article, support for a clear statement of States’ obligations during armed conflict and other emergencies was broad-based and came from all regions.
Relational legal pluralism and Indigenous legal orders in Canada
Authors: McKerracher Kelty 
Published: October 2022

AbstractThe survival and resurgence of Indigenous legal orders and constitutional traditions in Canada, as elsewhere, disrupt the normative hegemony of the liberal state and articulate a constitutionalism that accounts for a plurality of laws. How can state and non-state legal orders interact across vastly different normative worlds? How can their interaction address the colonial power imbalance and what role should recognition play in this relationship? This article draws on the work of Ralf Michaels on relational legal pluralism and Aaron Mills on Anishinaabe constitutionalism to explore how a legally plural society must embrace Michaels’ challenge of constitutive external recognition: the idea that legal orders mutually constitute each other through recognition without interfering with each other’s factual status as law. External recognition is consistent with strong legal pluralism and is distinct from recognition within the multicultural liberal state, a form of weak legal pluralism and continued colonialism. Mills’ discussion of treaty, rather than contract, as a foundation for shared political community assists in imagining a constitutionalism with/in Canada in which distinct legal orders can mutually constitute each other without domination. Linkage norms may help to establish reciprocal relations among state law and Indigenous legal orders, and the enactment of such ‘tertiary rules of recognition’ from within Indigenous legal orders may itself shift the balance of power.
Recent Changes of Phytoplankton Bloom Phenology in the Northern High‐Latitude Oceans (2003–2020)
Authors: Zhao Haipeng , Matsuoka Atsushi , Manizza Manfredi , Winter Amos 
Published: October 2022

AbstractEighteen years (2003–2020) of data on remotely‐sensed ocean color in high northern latitudes show a significant increase (0.56% yr−1) in double blooms of phytoplankton. Starting in 2015 the rate of increase rose to 1.10% yr−1. Double blooms have become especially prevalent in regions north of 50°N in the North Atlantic, Gulf of Alaska and southern Chukchi Sea. Our correlation analysis suggests that double bloom occurrences are dependent on latitude and seasonal changes in both sea surface temperature (SST) and mixed layer depth (MLD), particularly in the subpolar North Pacific (SNP) and polar oceans (65°–75°N), although we cannot attribute the increased double blooms to specific causes. Single blooms indicated by Chlorophyll a (Chl a) dominate in subpolar‐polar waters and occur close to the timing of the Particulate Inorganic Carbon (PIC) peak (i.e., June–August). In the SNP single bloom, Chl a peaks occur earlier than PIC peaks. This interval was shorter during 2016–2020, which is associated with warming anomalies. In the southern part of the Chukchi Sea, however, we found that PIC peaks occur earlier than Chl a peaks, suggesting a potentially different succession pattern between calcifiers and other functional groups. We speculate that in the near future double blooms of phytoplankton will become a prevalent feature in high‐latitude oceans with concurrent changes in the timing of blooms and seasonal phytoplankton succession in the surface ocean due to climate change.
The 2021 Mw 7.3 East Cape Earthquake: Triggered Rupture in Complex Faulting Revealed by Multi‐Array Back‐Projections
Authors: Xie Y. , Meng L. , Zhou T. , Xu L. , Bao H. , Chu R. 
Published: October 2022

AbstractOn 04 March 2021 the Mw 7.3 East Cape, New Zealand earthquake occurred at the southern end of the Kermadec Trench. The United States Geological Survey W‐phase solution shows an unexpected focal mechanism compared to historical earthquakes. We combine earthquake back‐projections of 4 arrays to image the kinematic process of the Mw 7.3 earthquake. Our results reveal a bilateral rupture predominantly propagating upward at a slow speed of 1 km/s and a triggered rupture at ∼10 km, corresponding to the deep reverse faulting event at 70 km and a triggered shallow normal faulting event (∼20 km) resolved by previous subevent and finite fault inversions. The epicenter and a group of aftershocks are deeper than the bottom of the slab according to a regional tomography model. Such deep failure is possibly enabled by a delaminating lower crust of the Hikurangi plateau.
Using CMIP6 Models to Assess the Significance of the Observed Trend in the Atlantic Meridional Overturning Circulation
Authors: Kelson R. L. , Straub D. N. , Dufour C. O. 
Published: October 2022

AbstractObservations from the RAPID array at 26.5°N suggest a weakening in the Atlantic meridional overturning circulation between 2004 and 2020. The shortness of this time series raises the question of whether this weakening should be thought of as natural variability or as related to climate change. To estimate natural variability, preindustrial control runs of the Coupled Model Intercomparison Project Phase 6 are used and the observed weakening is found to fall within the distribution of naturally occurring trends. These trends result from model variability on periods longer than the observational window, and variation between models at these frequencies is especially pronounced. Finally, adding noise to inflate model variability also inflates model trends; however, the effect on trends is sensitive only to the low frequency portion of the noise spectrum.
Detrainment Dominates CCN Concentrations Around Non‐Precipitating Convective Clouds Over the Amazon
Authors: Braga Ramon C. , Rosenfeld Daniel , Andreae Meinrat O. , Pöhlker Christopher , Pöschl Ulrich , Voigt Christiane , Weinzierl Bernadett , Wendisch Manfred , Pöhlker Mira L. , Harrison Daniel 
Published: October 2022

AbstractWe investigated the relationship between the number concentration of cloud droplets (Nd) in ice‐free convective clouds and of particles large enough to act as cloud condensation nuclei (CCN) measured at the lateral boundaries of cloud elements. The data were collected during the ACRIDICON‐CHUVA aircraft campaign over the Amazon Basin. The results indicate that the CCN particles at the lateral cloud boundaries are dominated by detrainment from the cloud. The CCN concentrations detrained from non‐precipitating convective clouds are smaller compared to below cloud bases. The detrained CCN particles from precipitating cloud volumes have relatively larger sizes, but lower concentrations. Our findings indicate that CCN particles ingested from below cloud bases are activated into cloud droplets, which evaporate at the lateral boundaries and above cloud base and release the CCN again to ambient cloud‐free air, after some cloud processing. These results support the hypothesis that the CCN around the cloud are cloud‐processed.
Microphysical Differences in the Concentric Eyewalls of Typhoon Lekima (2019)
Authors: Bao Xuwei , Zhang Shuai , Liang Yan 
Published: October 2022

AbstractUsing polarimetric radar observations, different microphysical characteristics were found in the asymmetric concentric eyewalls of Typhoon Lekima (2019). In addition to the differential reflectivity (ZDR) column, a typical size‐sorting radar signature was evident in the upright inner eyewall: a cyclonically upwind offset of the ZDR maximum relative to the horizontal reflectivity (ZH) and specific differential phase (KDP) maxima. In contrast, the large values of ZDR were located above the melting layer along the upper edge of the more tilted outer eyewall and did not extend downward to form a ZDR column. In the cyclonic direction, moreover, the large values of the three polarimetric variables in the outer eyewall almost overlapped, without the cyclonic offset of typical size‐sorting radar signature. Thus, more active warm‐cloud (cold‐cloud) processes dominate in the outer (inner) eyewall, particularly for the production of large drops, closely associated with the intrinsic dynamical structure of the concentric eyewalls.
Geophysical Evidence for Magmatism Southwest of the Brothers Islands, Northern Red Sea (Offshore Quseir, Egypt)
Authors: Ali Moamen , Ligi Marco , Ceriani Andrea , Bouchaala Fateh , Bosworth William , Decarlis Alessandro 
Published: October 2022

AbstractThe Red Sea formed as a consequence of Cenozoic rifting between the African and Arabian plates. While continuous oceanic spreading is active in the southern and central sectors, in the northern Red Sea, exposure of oceanic crust is limited to a few along‐axis isolated deeps. However, several off‐axis magmatic edifices have been recognized in this sector, their description in terms of relative age and architectural features remains vague. One of these, offshore Quseir corresponding to a kilometer‐size structural high, was studied in detail using 3D industrial seismic data. This structure is interpreted as due to the coalescence of different volcanic edifices developed on the footwall of a major rift‐related normal fault. Magnetic and gravity data and forward modeling suggest a volcanic nature of the substratum underlying the morphological relief. A similar volcanic origin is proposed for other neighboring basement hills that show a similar magnetic signal. Relationships with the imaged seismo‐stratigraphic sequences point to a Pleistocene age for the magmatic event. Arabian alkali‐basalts, at the same latitude as Quseir, show ages comparable to those inferred for the volcano edifice studied, suggesting a similar geotectonic context. In western Arabian plate, large alkali‐lava fields (Harrats) developed along rift‐related faults since the early stages of the Red Sea rift (Late Oligocene). They display a significant northward rejuvenation trend that may be explained by the progressive propagation of the Afar mantle plume.
SWAT_DA: Sequential Multivariate Data Assimilation‐Oriented Modification of SWAT
Authors: Bayat Mehrad , Alizadeh Hosein , Mojaradi Barat 
Published: October 2022

AbstractMultivariate data assimilation (DA), a novel way to couple big data with land surface models, was extensively employed in forecasting‐reanalyzing systems (FRSs), for example, ECMWF and GLDAS. Meanwhile, most (distributed) hydrological models, like soil and water assessment tool (SWAT), have not been equipped with straightforward ways to link to DA algorithms. Therefore, it is one of the main barriers to utilizing such hydrological models in FRSs. This paper deals with multivariate DA into SWAT (DA‐SWAT), which is complicated since the original model does not provide full access to the models' initial conditions (ICs) at the hydrologic response unit (HRU) scale. The preceding DA‐SWAT works commonly used an integrated approach in which the DA and SWAT codes were implemented in the same programming environment. We discuss how this approach complicates and prevents the application of DA‐SWAT in multivariate, multimodel, and multisensor systems. Accordingly, we proposed a new approach for DA‐SWAT by which SWAT can be perfectly linked with any DA algorithm of interest coded in any desired programming environment. Our framework utilizes input/output text files to access ICs and to link DA with SWAT. Moreover, we designed some univariate and multivariate scenarios for assimilating in situ streamflow measurement and MODIS's snow cover fraction (SCF) data, which has not yet been focused on in the SWAT calibration context. Results show that compared to the univariate assimilation of streamflow (SCF), the multivariate assimilation mitigates the equifinality problem and more accurately estimates SCF (streamflow) by improving NS and PBIAS measures with the differences of 0.4 (0.86), 12% (64%), respectively.
A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer
Authors: Kim Mijeong , Singh Manjot , Lee Bum-Kyu , Hibbs Moira , Richardson Kirsty , Ellies Lesley , Wintle Larissa , Stuart Lisa M. , Wang Jenny Y. , Voon Dominic C. , Blancafort Pilar , Wang Jianlong , Kim Jonghwan , Leedman Peter J. , Woo Andrew J. 
Published: October 2022

AbstractThe MYC proto-oncogene (MYC) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease progression and poor prognosis. In this study, we identified zinc finger transcription factor 148 (ZNF148, also called Zfp148 and ZBP-89) as a direct target of MYC. ZNF148 suppressed cell proliferation and migration and was transcriptionally repressed by MYC in breast cancer. Depletion of ZNF148 by short hairpin RNA (shRNA) and CRISPR/Cas9 increased triple-negative breast cancer (TNBC) cell proliferation and migration. Global transcriptome and chromatin occupancy analyses of ZNF148 revealed a central role in inhibiting cancer cell de-differentiation and migration. Mechanistically, we identified the Inhibitor of DNA binding 1 and 3 (ID1, ID3), drivers of cancer stemness and plasticity, as previously uncharacterized targets of transcriptional repression by ZNF148. Silencing of ZNF148 increased the stemness and tumorigenicity in TNBC cells. These findings uncover a previously unknown tumor suppressor role for ZNF148, and a transcriptional regulatory circuitry encompassing MYC, ZNF148, and ID1/3 in driving cancer stem cell traits in aggressive breast cancer.
Utilizing ferrorestorable polarization in energy-storage ceramic capacitors
Authors: Matsuo Hiroki , Utsunomiya Masashi , Noguchi Yuji 
Published: October 2022

AbstractA self-powered system with a long lifetime would represent an opportunity in the development of a next-generation, standalone Internet of Things. Ceramic capacitors are promising candidates for energy storage components because of their stability and fast charge/discharge capabilities. However, even the energy density of state-of-the-art capacitors needs to be increased markedly for this application. Improving the breakdown electric field represents a potential solution, but operations at such high fields relying on unchanged dielectric permittivity sacrifice the lifetime of the capacitor to some degree. Here, we report ferrorestorable polarization engineering capable of more than doubling the effective permittivity. Our experiments and ab initio calculations demonstrate that a defect dipole composed of Cu3+ and oxygen vacancy in a prototypical ferroelectric BaTiO3 ceramic is coupled with spontaneous polarization. The resultant ferrorestorable polarization delivers an extraordinarily large effective relative permittivity, beyond 7000, with a high energy efficiency up to 89%. Our work paves the way to realizing efficient ceramic capacitors for self-powered applications.
Assembling defined DNA nanostructures with anticancer drugs: a metformin/DNA complex nanoplatform with a synergistic antitumor effect for KRAS-mutated lung cancer therapy
Authors: Qian Hang , Wang Dong , He Binfeng , Liu Qian , Xu Yu , Wu Di , Chen Chunfa , Zhang Wen , Leong David Tai , Wang Guansong 
Published: October 2022

AbstractHerein, a strategy is proposed to simultaneously deliver the small-molecule drug metformin and siRNA with self-assembled DNA nanostructures. The biomedical application of DNA nanostructures is highly promising but still in its infancy. DNA nanostructures as drug delivery vehicles are conventionally synthesized in a magnesium-containing buffer. We propose using an anticancer drug to assemble DNA nanostructures and deliver them with siRNA for synergistic anticancer therapy. The metformin cargo induces DNA self-assembly into well-defined, uniform nanostructures, producing a drug–DNA nanocomplex with multiple functionalities for cancer therapy. Both tile-based and DNA origami structures can be assembled with metformin. The as-prepared metformin/DNA nanocomplex showed high structural and thermal stability and enzymatic resistance in physiological settings. The metformin in the nanocomplex and the KRASG12C siRNA exerted a strong, synergistic antitumor effect against KRAS-mutated non-small cell lung cancer (NSCLC) both in vitro and in vivo by suppressing the RAS/AKT/mTOR and AMPK/AKT/mTOR signaling pathways. The current study suggests that the assembly of complex DNA nanomaterials with carefully chosen small molecules is key to endowing DNA nanostructures with new functionalities and subsequently expanding their applications in multidisciplinary research fields.
Characteristics and treatment response of polypoidal choroidal vasculopathy in highly myopic eyes
Authors: Huang Wei-Lun , Hsia Yun , Wang Shih-Wen , Hung Kuo-Chi , Huang Chien-Jung , Chen Muh-Shy , Ho Tzyy-Chang 
Published: October 2022

Abstract
Background
To compare the characteristics and treatment responses of polypoidal choroidal vasculopathy (PCV) between highly myopic and non-highly myopic eyes.

Methods
This retrospective cohort study included patients diagnosed with PCV at the clinic of National Taiwan University Hospital between 2013 and 2019. The diseased eyes were grouped per refractive error and axial length at diagnosis. Imaging data were used to retrieve the PCV characteristics, and electronic medical records were used to retrieve the treatment responses.

Results
Among 116 eyes with PCV, 11 eyes of 10 patients were highly myopic; seven of these patients were women. All highly myopic eyes showed a thin subfoveal choroid, while three eyes had a pachychoroid phenotype with significant focal choroidal thickening. After treatment with either intravitreal anti-vascular endothelial growth factor (VEGF) injections, photodynamic therapy (PDT), or both, best-corrected visual acuity was better in the high-myopia group at 1 year. Visual acuity at presentation and the presence of feeder vessels were found to be predictors of the visual outcome.

Conclusions
In this study we reported, to the best of our knowledge, the largest cohort of PCV in highly myopic eyes to date. Female predominance, lower incidence of subretinal haemorrhage, and a thin choroid with a focal pachychoroid phenotype were found to characterise PCV in highly myopic eyes. Visual acuity transiently improved after either anti-VEGF monotherapy or combination therapy with PDT.
Practical implementation of a q4–q16 aflibercept treat-and-extend pathway for the treatment of neovascular age-related macular degeneration: Updated guidance from a UK expert panel
Authors: Bailey Clare , Cackett Peter , Kotagiri Ajay , Mahmood Sajjad , Minos Evangelos , Narendran Nirodhini , Patwardhan Ashish , Sim Dawn A. , Morgan-Warren Peter , O’Neil Carolyn , Straw Katie 
Published: October 2022

Abstract
Objectives
This report, based on guidance from a panel of UK retina specialists, introduces a revised intravitreal aflibercept (IVT-AFL) treat-and-extend (T&E) pathway for the treatment of neovascular age-related macular degeneration (nAMD). The T&E pathway incorporates the updated IVT-AFL label (April 2021) allowing flexible treatment intervals of 4 weeks to 16 weeks, after three initiation doses and a further dose after 8 weeks. Practical guidance is provided on the clinical implementation of the revised pathway, with the aim of supporting clinical decision-making to benefit patients and addressing capacity issues in nAMD services.

Methods
Three structured round-table meetings of UK retina specialists were held online on 19 May, 16 June and 13 October 2021. These meetings were organised and funded by Bayer.

Results
The authors revised the previously published consensus pathway to reflect the changes to the IVT-AFL label and developed guidelines for the implementation of the pathway in UK clinical practice. The guidelines include topics such as recommendations for extending patients with 2- or 4-week adjustments, extending patients to 16-week treatment intervals, managing fellow eye involvement, and reducing treatment intervals for patients with particularly active disease.

Conclusions
The revised IVT-AFL T&E nAMD pathway offers guidance to clinicians seeking to increase the dosing flexibility of IVT-AFL, with 4- to 16-week treatment intervals, in line with the updated IVT-AFL label, to meet the continually evolving demands of nAMD service provision.