bluuebunny/crossref_metadata_2025_split huggingface dataset:
Far-field super-resolution ghost imaging with a deep neural network constraint
Authors: Wang Fei , Wang Chenglong , Chen Mingliang , Gong Wenlin , Zhang Yu , Han Shensheng , Situ Guohai 
Published: January 2022

AbstractGhost imaging (GI) facilitates image acquisition under low-light conditions by single-pixel measurements and thus has great potential in applications in various fields ranging from biomedical imaging to remote sensing. However, GI usually requires a large amount of single-pixel samplings in order to reconstruct a high-resolution image, imposing a practical limit for its applications. Here we propose a far-field super-resolution GI technique that incorporates the physical model for GI image formation into a deep neural network. The resulting hybrid neural network does not need to pre-train on any dataset, and allows the reconstruction of a far-field image with the resolution beyond the diffraction limit. Furthermore, the physical model imposes a constraint to the network output, making it effectively interpretable. We experimentally demonstrate the proposed GI technique by imaging a flying drone, and show that it outperforms some other widespread GI techniques in terms of both spatial resolution and sampling ratio. We believe that this study provides a new framework for GI, and paves a way for its practical applications.
Light People: Professor Byoungho Lee
Authors: Wang Hui , Yu Cun 
Published: January 2022

EditorialMajor developments were made recently in both VR (virtual reality) and AR (augmented reality) technologies, which became the focus of attention. In recent years, MR (mixed reality) technology has also emerged, and optical components play an irreplaceable role in these technologies.Professor Byoungho Lee, who graduated from the University of California at Berkeley and currently works at Seoul National University in South Korea, has been committed to the development of optical components used in VR and AR technologies. As a pioneer of optical electronics in Korea, he is involved in various well-known academic organizations in the optical field, such as the Optica, SPIE, and IEEE, as well as serving as the president of the Optical Society of Korea, leading the direction of the development of optical industry in Korea. As the ambassador of China-Korea Optoelectronics Exchange, Prof. Lee has also played an active role in Chinese optical events and activities. Over the years, he and the Journal Light: Science & Applications (LIGHT) have made progress together and have both made their names in the vast field of optoelectronics.So where did the story between Prof. Lee and the LIGHT journal begin? And what kind of link does the professor have with Changchun Institute of Optics, Fine Mechanics and Physics (CIOMP)? How did he become a pioneer in optoelectronics technology? These are the questions we are eager to ask Prof. Byoungho Lee.The future cannot be predicted, but it can be invented, said Dennis Gabor who had invented holography. The pace of human technological advancements has never stopped. Who is to say that we cannot take a virtual tour of the Palace Museum or explore the north and south poles in the future? Scientists like Prof. Lee are working hard to use technology to provide mankind with an intelligent lifestyle, and lead a new technological trend. I am sure we are all looking forward to it.
A flexible capacitive photoreceptor for the biomimetic retina
Authors: Vijjapu Mani Teja , Fouda Mohammed E. , Agambayev Agamyrat , Kang Chun Hong , Lin Chun-Ho , Ooi Boon S. , He Jr-Hau , Eltawil Ahmed M. , Salama Khaled N. 
Published: January 2022

AbstractNeuromorphic vision sensors have been extremely beneficial in developing energy-efficient intelligent systems for robotics and privacy-preserving security applications. There is a dire need for devices to mimic the retina’s photoreceptors that encode the light illumination into a sequence of spikes to develop such sensors. Herein, we develop a hybrid perovskite-based flexible photoreceptor whose capacitance changes proportionally to the light intensity mimicking the retina’s rod cells, paving the way for developing an efficient artificial retina network. The proposed device constitutes a hybrid nanocomposite of perovskites (methyl-ammonium lead bromide) and the ferroelectric terpolymer (polyvinylidene fluoride trifluoroethylene-chlorofluoroethylene). A metal-insulator-metal type capacitor with the prepared composite exhibits the unique and photosensitive capacitive behavior at various light intensities in the visible light spectrum. The proposed photoreceptor mimics the spectral sensitivity curve of human photopic vision. The hybrid nanocomposite is stable in ambient air for 129 weeks, with no observable degradation of the composite due to the encapsulation of hybrid perovskites in the hydrophobic polymer. The functionality of the proposed photoreceptor to recognize handwritten digits (MNIST) dataset using an unsupervised trained spiking neural network with 72.05% recognition accuracy is demonstrated. This demonstration proves the potential of the proposed sensor for neuromorphic vision applications.
Ultrafast imaging of terahertz electric waveforms using quantum dots
Authors: Heindl Moritz B. , Kirkwood Nicholas , Lauster Tobias , Lang Julia A. , Retsch Markus , Mulvaney Paul , Herink Georg 
Published: January 2022

AbstractMicroscopic electric fields govern the majority of elementary excitations in condensed matter and drive electronics at frequencies approaching the Terahertz (THz) regime. However, only few imaging schemes are able to resolve sub-wavelength fields in the THz range, such as scanning-probe techniques, electro-optic sampling, and ultrafast electron microscopy. Still, intrinsic constraints on sample geometry, acquisition speed and field strength limit their applicability. Here, we harness the quantum-confined Stark-effect to encode ultrafast electric near-fields into colloidal quantum dot luminescence. Our approach, termed Quantum-probe Field Microscopy (QFIM), combines far-field imaging of visible photons with phase-resolved sampling of electric waveforms. By capturing ultrafast movies, we spatio-temporally resolve a Terahertz resonance inside a bowtie antenna and unveil the propagation of a Terahertz waveguide excitation deeply in the sub-wavelength regime. The demonstrated QFIM approach is compatible with strong-field excitation and sub-micrometer resolution—introducing a direct route towards ultrafast field imaging of complex nanodevices in-operando.
Singleton exome sequencing of 90 fetuses with ultrasound anomalies revealing novel disease-causing variants and genotype–phenotype correlations
Authors: Smogavec Mateja , Gerykova Bujalkova Maria , Lehner Reinhard , Neesen Jürgen , Behunova Jana , Yerlikaya-Schatten Gülen , Reischer Theresa , Altmann Reinhard , Weis Denisa , Duba Hans-Christoph , Laccone Franco 
Published: January 2022

AbstractExome sequencing has been increasingly implemented in prenatal genetic testing for fetuses with morphological abnormalities but normal rapid aneuploidy detection and microarray analysis. We present a retrospective study of 90 fetuses with different abnormal ultrasound findings, in which we employed the singleton exome sequencing (sES; 75 fetuses) or to a lesser extent (15 fetuses) a multigene panel analysis of 6713 genes as a primary tool for the detection of monogenic diseases. The detection rate of pathogenic or likely pathogenic variants in this study was 34.4%. The highest diagnostic rate of 56% was in fetuses with multiple anomalies, followed by cases with skeletal or renal abnormalities (diagnostic rate of 50%, respectively). We report 20 novel disease-causing variants in different known disease-associated genes and new genotype–phenotype associations for the genes KMT2D, MN1, CDK10, and EXOC3L2. Based on our data, we postulate that sES of fetal index cases with a concurrent sampling of parental probes for targeted testing of the origin of detected fetal variants could be a suitable tool to obtain reliable and rapid prenatal results, particularly in situations where a trio analysis is not possible.
An update on long-acting therapies in chronic sight-threatening eye diseases of the posterior segment: AMD, DMO, RVO, uveitis and glaucoma
Authors: Ghanchi Faruque , Bourne Rupert , Downes Susan M. , Gale Richard , Rennie Christina , Tapply Ian , Sivaprasad Sobha 
Published: January 2022

AbstractIn the real-world setting, there is suboptimal compliance with treatments that require frequent administration and assessment visits. This undertreatment frequently has negative consequences in eye disease and carries a real risk to vision. For example, patients with glaucoma risk progression of visual loss even with a small number of missed doses, and patients with neovascular age-related degeneration (nAMD) who fail to attend a bi-monthly clinic appointment to receive an intravitreal anti-vascular endothelial growth factor (VEGF) drug injections may lose the initial vision gains in vision. Protracted regular treatment schedules represent a high burden not only for patients and families, but also healthcare professionals, systems, and ultimately society too. There has been a clear need for longer-acting therapies that reduce the frequency, and therefore the burden, of treatment interventions. Several longer-acting interventions for nAMD, diabetic macular oedema, retinal vein occlusion, uveitis and glaucoma have either been developed or are in late-phase development, some of which employ novel mechanisms of actions, and all of which of promise longer (≥3 month) treatment intervals. This review delivers an overview of anti-VEGF agents with longer durations of action, DARPins, bispecific anti-VEGF/Ang2 therapies, anti-PDGF and anti-integrin therapy, Rho-kinase inhibitors, the Port Delivery System, steroids, gene therapy for retina and uveitis, and for glaucoma, ROCK inhibitors, implants and plugs, and SLT laser and MIGS. The review also refers to the potential of artificial intelligence to tailor treatment efficacy with a resulting reduction in treatment burden.
Electrophysiological and fundoscopic detection of intracranial hypertension in craniosynostosis
Authors: Rufai Sohaib R. , Marmoy Oliver R. , Thompson Dorothy A. , van de Lande Lara S. , Breakey R. William , Bunce Catey , Panteli Vasiliki , Schwiebert Kemmy , Mohamed Shafquet , Proudlock Frank A. , Gottlob Irene , Dunaway David J. , Hayward Richard , Bowman Richard , Jeelani Noor ul Owase 
Published: January 2022

AbstractAimsTo assess the diagnostic accuracy of fundoscopy and visual evoked potentials (VEPs) in detecting intracranial hypertension (IH) in patients with craniosynostosis undergoing spring-assisted posterior vault expansion (sPVE).MethodsChildren with craniosynostosis undergoing sPVE and 48-hour intracranial pressure (ICP) monitoring were included in this single-centre, retrospective, diagnostic accuracy study. Data for ICP, fundoscopy and VEPs were analysed. Primary outcome measures were papilloedema on fundoscopy, VEP assessments and IH, defined as mean ICP > 20 mmHg. Diagnostic indices were calculated for fundoscopy and VEPs against IH. Secondary outcome measures included final visual outcomes.ResultsFundoscopic examinations were available for 35 children and isolated VEPs for 30 children, 22 of whom had at least three serial VEPs. Sensitivity was 32.1% for fundoscopy (95% confidence intervals [CI]: 15.9–52.4) and 58.3% for isolated VEPs (95% CI 36.6–77.9). Specificity for IH was 100% for fundoscopy (95% CI: 59.0–100) and 83.3% for isolated VEPs (95% CI: 35.9–99.6). Where longitudinal deterioration was suspected from some prVEPs but not corroborated by all, sensitivity increased to 70.6% (95% CI: 44.0–89.7), while specificity decreased to 60% (95% CI: 14.7–94.7). Where longitudinal deterioration was clinically significant, sensitivity decreased to 47.1% (23.0–72.2) and specificity increased to 100% (47.8–100). Median final BCVA was 0.24 logMAR (n = 36). UK driving standard BCVA was achieved by 26 patients (72.2%), defined as ≥0.30 logMAR in the better eye.ConclusionPapilloedema present on fundoscopy reliably indicated IH, but its absence did not exclude IH. VEP testing boosted sensitivity at the expense of specificity, depending on method of analysis.
Cancer in the Adolescent and Young Adults (AYA) and Children: A Comprehensive Analysis of the Epidemiology and Psychosocial Morbidity in the Indian Population
Authors: Guleria Bhupesh , Viswanath S. , Soneji Dharmesh , Kapoor Rajan , Guleria Prerna , Suresh P. , Kumar Manish , Patel Amol , Swamy Shivshankar 
Published: January 2022

Aims Adolescent and young adults (AYAs), children with cancer, and their guardians have unique psychosocial morbidities adversely effecting quality of life (QOL). This is measurable using patented tools. We analyzed epidemiological and clinicopathological patterns of solid organ cancers in this subgroup. We also assessed psychosocial morbidity and changes in QOL faced by them.Methods All patients aged 2 to 39 years, newly diagnosed with cancer from April 2017 to March 2019 were included. Clinical history, diagnosis, staging, treatment, outcomes, and follow-up were recorded. The National Comprehensive Cancer Network (NCCN) distress thermometer and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ C-30) were used to assess psychosocial morbidity of AYAs, children ≥ 12 years, and parents of children < 12 years. Pediatric Quality of Life Inventory (Peds QL) version 3.0 was used for children < 12 years. Data was analyzed using descriptive statistics.Results A total of 571 patients (512 AYAs, 59 children) were enrolled. Median age was 30 years with male predominance (58.1%). Most cases (98.6%) were absent from school or work. Carcinoma breast was the most common in females (29.3%) and non-Hodgkin lymphoma in males (12.6%). 91.06% had overall NCCN distress score ≥ 4. Also, 73.81 and 79.49% had “quite a bit” or “very much” responses on functional and symptom scales, respectively, in EORTC QLQ C-30 questionnaire. Peds QL version 3.0 revealed total score ranging from 276 to 523 for each patient.Conclusion AYAs and children with cancer are extremely vulnerable to psychological stress and morbidity. Use of well-established tools help in assessing their mental status and timely psychiatric referral can be initiated.
Cancer Scenario in Kashmir—A Study Conducted in a Tertiary Care Center, Srinagar, Kashmir, India
Authors: Waheed Dar Abdul , Sumaira Saba , Ahmad Lone Mushtaq , Ain Qurat Ul , Kuchay Sanaullah , Dar Nazir Ahmad 
Published: January 2022

Background Cancer can have profound social and economic consequences for the people in India, often leading to family impoverishment and societal inequity. Reported age-adjusted incidence rates for cancer are still quite low in the demographically young country. Slightly more than 1 million new cases of cancer are diagnosed every year in a population of 1.2 billion. It accounts for about 23 and 7% deaths in United States and India, respectively. The world's population is expected to be 7.5 billion by 2020 and approximations predict that about 15.0 million new cancer cases will be diagnosed, with deaths of about 12.0 million cancer patients. Early detection of cancers is a challenging task because clinical symptoms develop slowly.
Objective The aim of the present study was to analyze the cancer scenario in the Kashmir valley.
Materials and Methods This was a retrospective study. So, all patients were included who had histopathologically confirmed neoplasm registered at Regional Cancer Centre of Government Medical College Srinagar, Kashmir between 2015 and 2018. All the patient characteristics including age, sex, and anatomical site of the disease were studied in detail.
Results The number of cancer patients in 2015, 2016, 2017, and 2018 were 230, 239, 391, and 511, respectively, with a combined total of 1,371. Thus, it is clear from these figures that the number of cancer cases has increased gradually with time. Stomach cancer is the most common cancer in the Kashmir territory. In males the most common cancer is stomach cancer with 175 (12.8%) reported cases and in females the most common cancer is breast cancer with 151 (11%) reported cases. The male to female ratio was 1.4:1.
Conclusion A careful reading the reported cancer cases indicates an increased number of cancer patients every year in Indian-occupied Kashmir. Kashmir is a growing state in India playing a crucial role in the development of India and, hence, it needs special attention on this issue. A multidisciplinary approach to cancer treatment is essential and this has to be made available at all regional cancer centers. Cancer control is an area in which we need participation from all sectors of the society.
Novel Use of Dual Guiding Catheters Technique to Prevent Distal Embolization and Slow Flow during PCI of Coronary Stent Thrombosis
Authors: Trehan Vijay Kumar , Jain Gagan , Gupta Puneet 
Published: January 2022

AbstractDespite having an incidence of 0.5 to 2%, stent thrombosis has an in-hospital mortality of 15% and myocardial infarction (MI) incidence of 67%. Even with the usage of thrombus aspiration devices and microvasculature vasodilators such as nitroprusside, verapamil, adenosine, and Gp2b/3a inhibitors, the angiographic result of percutaneous coronary intervention of coronary stent thrombosis remains frequently suboptimal due to distal embolization and subsequent slow flow. We describe a novel use of dual guide catheter technique, where one guide acts as conduit for thrombus aspiration catheter and the other for distal placement of balloon trap to prevent distal embolization while managing a case of coronary stent thrombosis to improve the angiographic outcome in this scenario.
Reconstruction of the Distal Oblique Bundle for DRUJ Instability
Authors: Thomsen Niels O.B. , Björkman Anders 
Published: January 2022

Abstract
Background Treatment algorithm for disruption of the triangular fibrocartilage complex (TFCC) from the ulnar fovea includes direct TFCC repair, tendon reconstruction of the radioulnar ligaments, or a salvage procedure in cases with painful distal radioulnar joint (DRUJ) degeneration.
Case Description We describe our surgical technique for reconstruction of the distal oblique bundle (DOB), to attain DRUJ stability in a young man, after failed attempts of direct TFCC reinsertion and radioulnar ligament reconstruction with the Adams procedure.
Literature Review Reconstruction of the central band of the interosseous membrane is well recognized for Essex-Lopresti injuries that demonstrate longitudinal forearm instability. The role for reconstruction/reinforcement of the DOB to restore DRUJ stability after TFCC injury has not gained the same recognition and needs further clarification.
Clinical Relevance DOB reconstruction technique described is extra-articular and technically straightforward. We believe that the procedure could be considered for patients with an irreparable TFCC injury as a part of the treatment algorithm for younger patients, who otherwise would face a more extensive salvage procedure.
Visibility of Transcondylar Screw Fractures in Standard and Extended Scale Computed Tomography Images
Authors: Brash Robert , Labrador Jose , Holdsworth Andrew 
Published: January 2022

AbstractObjective Application of extended computed tomography scale (ECTS) reconstruction to diagnose metal implant failure has been described in a single case report. The purpose of this study was to compare the features and visibility of humeral transcondylar screw fractures in standard CT scale (SCTS) and ECTS images.Study Design Case series: CT images of dogs with fractured transcondylar screws were retrospectively reviewed and described in both SCTS and ECTS images.Results Five dogs with a total of six transcondylar screw failures (five right and one bilateral) were reviewed. All cases had an ongoing humeral intercondylar fissure with varying degrees of stress remodelling. The fracture was seen in all screws on ECTS images, however only in three implants on SCTS images. The measured fracture gap was larger in ECTS images in all cases (range: + 0.14 mm to + 0.28mm). The three smallest fracture gaps were not seen on SCTS images. A subtle hypoattenuating streak (artefact) was visible adjacent to the screw fracture in 5/6 of cases using SCTS images. All screw fractures occurred parallel and often slightly medial to the humeral intercondylar fissure.Conclusion Implant failure is only seen with larger fracture gaps in SCTS images, with 3/6 screw fractures not visible in SCTS compared with ECTS. A hypoattenuating streak extending perpendicular to the implant in SCTS images is suggestive of screw fracture even if this is not directly visible.
Hardwired to attack. Candidates’ personality traits and negative campaigning in three European countries
Authors: Nai Alessandro , Tresch Anke , Maier Jürgen 
Published: January 2022

AbstractA growing body of studies shows that the reasons for competing candidates to “go negative” on their opponents during elections—that is, attacking their opponents instead of promoting their own programs or ideas stem from strategic considerations. Yet, existing research has, at this stage, failed to assess whether candidates’ personality traits also play a role. In this article, we bridge the gap between existing work in political psychology and political communication and study to what extent the personality traits of competing candidates are linked with their use of negative campaigning strategies. We rely on candidate survey data for recent elections in three countries—Germany (2017), Switzerland (2019), and Finland (2019). The data includes self-reported measures for candidates’ “Big Five” personality traits (extraversion, agreeableness, conscientiousness, neuroticism, openness) and the the use of attacks towards their opponents during the campaign. Controlling for the usual suspects driving the use of negative campaigning we show that this latter is associated with low agreeableness and (marginally) with high extraversion and low conscientiousness. The role of personality for the focus of an attack (issue vs. character attacks) is somewhat less clear-cut. All in all, kinder and more stable candidates tend to go less negative; when they do, they tend to stay away from character-based attacks and somehow focus on issues.
Two Cases of Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections Caused by the Omicron Variant (B.1.1.529 Lineage) in International Travelers to Japan
Authors: Maruki Taketomo , Iwamoto Noriko , Kanda Kohei , Okumura Nobumasa , Yamada Gen , Ishikane Masahiro , Ujiie Mugen , Saito Masumichi , Fujimoto Tsuguto , Kageyama Tsutomu , Saito Tomoya , Saito Shinji , Suzuki Tadaki , Ohmagari Norio 
Published: January 2022

Abstract
In November 2021, the World Health Organization designated a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern, Omicron (PANGO lineage B.1.1.529). We report on the first 2 cases of breakthrough coronavirus disease 2019 (COVID-19) caused by Omicron in Japan among international travelers returning from the country with undetected infection. The spread of infection by Omicron were considered.