bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive language processing in young autistic children
Authors: Prescott Kathryn E. , Mathée‐Scott Janine , Reuter Tracy , Edwards Jan , Saffran Jenny , Ellis Weismer Susan 
Published: February 2022

AbstractRecent theories propose that domain‐general deficits in prediction (i.e., the ability to anticipate upcoming information) underlie the behavioral characteristics associated with autism spectrum disorder (ASD). If these theories are correct, autistic children might be expected to demonstrate difficulties on linguistic tasks that rely on predictive processing. Previous research has largely focused on older autistic children and adolescents with average language and cognition. The present study used an eye‐gaze task to evaluate predictive language processing among 3‐ to 4‐year‐old autistic children (n = 34) and 1.5‐ to 3‐year‐old, language‐matched neurotypical (NT) children (n = 34). Children viewed images (e.g., a cake and a ball) and heard sentences with informative verbs (e.g., Eat the cake) or neutral verbs (e.g., Find the cake). Analyses of children's looking behaviors indicated that young autistic children, like their language‐matched NT peers, engaged in predictive language processing. Regression results revealed a significant effect of diagnostic group, when statistically controlling for age differences. The NT group displayed larger difference scores between the informative and neutral verb conditions (in looks to target nouns) compared to the ASD group. Receptive language measures were predictive of looking behavior across time for both groups, such that children with stronger language skills were more efficient in making use of informative verbs to process upcoming information. Taken together, these results suggest that young autistic children can engage in predictive processing though further research is warranted to explore the developmental trajectory relative to NT development.Lay SummaryThis study found that 3‐ to 4‐year‐old autistic children and younger, language‐matched neurotypical (NT) children both used verbs to predict upcoming nouns in sentences like “Eat the cake.” For both autistic and NT children, those with stronger language skills were able to predict upcoming nouns more quickly.
Towards Understanding the Corrosion Behavior of Zinc‐Metal Anode in Aqueous Systems: From Fundamentals to Strategies
Authors: Li Qian , Han Lishun , Luo Qun , Liu Xiaoyu , Yi Jin 
Published: February 2022

AbstractOwing to the properties of cost‐efficient, high‐energy density and environmental friendliness, rechargeable aqueous zinc‐metal batteries (RAZMBs) are promising candidates for the next generation metal‐based batteries in large‐scale energy storage systems. However, the practical applications of RAZMBs are severely limited due to the presence of inevitable side reactions referring to zinc corrosion and hydrogen evolution reaction (HER) occurring at the electrode‐electrolyte interface. The uninterrupted interfacial side reactions at the expense of continuous capacity fading and reduced reversibility of zinc are required to give more attention to mitigate them. Given the above concerns, in this review, the fundamental principles of corrosion thermodynamics and kinetics of zinc electrodes in aqueous media are elucidated. Furthermore, the recent optimization strategies targeting enhanced stability of zinc electrodes are reviewed including electrolyte additives, zinc alloying, electrodeposited Zn and coating treatments. Finally, considering the current main research orientations, some perspectives are provided to facilitate the development of future applications of zinc anodes.
Impact of early palliative care according to baseline symptom severity: Secondary analysis of a cluster‐randomized controlled trial in patients with advanced cancer
Authors: Rodin Rebecca , Swami Nadia , Pope Ashley , Hui David , Hannon Breffni , Le Lisa W. , Zimmermann Camilla 
Published: February 2022

AbstractBackgroundEarly palliative care (EPC) improves the quality of life but may not be feasible for all patients with advanced cancer. Symptom screening has been suggested to triage patients for EPC, but scant evidence exists for this practice.MethodsWe conducted a subgroup analysis of a cluster‐randomized controlled trial of EPC vs. standard oncology care according to patients' baseline symptom scores (high [>23] vs. low [≤23] Edmonton Symptom Assessment System Distress Score [ESAS SDS]). A linear mixed‐effects model was used to account for correlation within clusters, adjusting for the baseline outcome score and all covariates in the original trial.ResultsAmong the 461 participants, baseline symptom scores were high in 229 patients (127 intervention, 102 control) and low in 232 (101 intervention and 131 control). Among those with high baseline symptoms, there was improved quality of life in the EPC arm compared to controls at 4 months (adjusted difference in primary outcome of FACIT‐Sp change score [95% CI], 8.7 [2.8 to 14.5], p = 0.01; adjusted difference in QUAL‐E, 4.2 [0.9–7.5], p = 0.02); there was also improved satisfaction with care (6.9 [3.8–9.9], p = 0.001) and clinician‐patient interactions (−1.7 [−3.4 to −0.1], p = 0.04), but no significant difference in ESAS SDS (−5.6 [−12.7 to 1.4], p = 0.11). In the low baseline symptom group, there were no significant differences between arms for any outcomes.ConclusionEPC improved quality of life, satisfaction with care, and clinician‐patient interactions only in those with high baseline symptoms. Symptom severity may be an appropriate criterion to trigger early referrals to palliative care.
Effortless online shopping? How online shopping contexts prime heuristic processing
Authors: Niza Braga João , Jacinto Sofia 
Published: February 2022

AbstractOnline shopping is often motivated by the opportunity to save resources due to its high convenience and accessibility. We thus propose that online‐shopping contexts can prime low effort processing, which increase heuristic decisions, when compared with offline contexts. Four experimental studies test this hypothesis. Study 1 shows that consumers expect to spend fewer resources in online than in offline shopping decisions. Studies 2 to 4 show that priming an online (vs. offline) shopping context increases reliance on heuristic cues in probability judgments (Study 2) and in product choices (Studies 3 and 4). Results further show that systematic processing of relevant nonheuristic information is reduced after priming online‐shopping contexts and suggest that resource‐saving expectations associated to online‐shopping mediate attitudes toward systematic‐options. This research brings novel and important contributions by investigating the role of online shopping contexts on the activation of resource‐saving expectations and on the use heuristic cues in consumer decisions. Limits and implications are discussed.
Variation in Compositions and Biological Activities of Essential Oils from Four Citrus Species: Citrus limon, Citrus sinensis, Citrus paradisi, and Citrus reticulata
Authors: Li Chunlian , Cai Qiuyang , Wu Xianyi , Tan Zekai , Huang Shiyuan , Wei Chuqi , Zhang Weicheng , Chen Zhuoyu , Zhang Lanyue , Xiang Hongping 
Published: February 2022

AbstractSpecies of the genus Citrus are cultivated in many regions of China and are widely used for medicinal purposes. In the present study, essential oils (EOs) were extracted from four different Citrus species using steam distillation. The chemical components of these four essential oils were separated using gas chromatography‐mass spectrometry, and 52 compounds were confirmed. D‐limonene was found to be the most abundant compound. All four essential oils demonstrated varied but remarkable radical scavenging capacity (IC50; 0.77–13.9 %). Citrus paradisi essential oil exhibited excellent antioxidant activity. Compared to ibuprofen, topical application of the four Citrus spp. essential oils significantly inhibited ear edema formation in mice. Furthermore, essential oils from the four Citrus species reduced the expression levels of interleukin‐6 (IL‐6), cyclooxygenase‐2 (COX‐2) and nuclear transcription factor kappa B p65 (NF‐κB) to different degrees. The cytotoxicity of the four essential oils on BV2 microglial cells was determined using the MTT assay (IC50; 321.37–1558.87 μg/mL), wherein Citrus limon essential oil showed the lowest cytotoxicity. The essential oils of Citrus limon, Citrus reticulata, and Citrus paradisi had an inhibitory effect on the lung cancer cell lines H1299 by inducing a G0/G1 cell cycle arrest. Cluster and principal component analyses were used to determine the relationship among the Citrus species. These results suggest that the four Citrus essential oils have potential for use as active ingredients in functional foods or cosmeceutical products.
USP25 inhibits DNA damage by stabilizing BARD1 protein in a house dust mite‐induced asthmatic model in vitro and in vivo
Authors: Gan Cong , Wang Ye , Zhao Qian , Kong Mi , Chen Jinnan , Zhang Wanying , Tan Lingxiao , Tian Man 
Published: February 2022

AbstractHouse dust mites (HDM) can cause DNA double‐strand breaks in the lungs of asthmatic patients. However, the molecular mechanisms driving DNA damage and repair in HDM‐induced asthma are yet to be elucidated. Thus, in this study, HDM treatment was applied to BEAS‐2B cells and mice to mimic the pathological process of asthma in vitro and in vivo, respectively. γ‐H2AX foci and expression were measured by immunofluorescence staining and western blot, respectively. The levels of interleukin (IL)‐4, IL‐6, IL‐13, and tumour necrosis factor α (TNFα) were measured using enzyme‐linked immunoassay. The expression of USP25 and BARD1 was measured by reverse transcription quantitative PCR and western blot. Co‐immunoprecipitation and ubiquitination assays were employed to detect the relationship between USP25 and BARD1. As per the results, it was found that the deubiquitylating enzyme USP25 repressed HDM‐induced DNA damage and the production of proinflammatory cytokines, including TNF‐α, IL‐4, IL‐8, and IL‐13, in BEAS‐2B cells; in contrast, the depletion of USP25 led to the opposite effects. USP25‐mediated inhibition of DNA damage and inflammation was facilitated by the stabilizing protein BARD1, which is a tumor suppressor that principally functions by promoting DNA repair and replication in BEAS‐2B cells. Furthermore, USP25 was found to robustly augment BARD1 protein abundance and prevent HDM‐induced DNA damage and inflammation in vivo. Taken together, these results suggest a novel mechanism contributing to DNA damage and repair in HDM‐induced asthma and that selectively modulating this pathway could lead to a novel therapeutic approach for controlling and managing asthma due to HDM exposure.
PMM2‐CDG and nephrotic syndrome: A case report
Authors: Banderali Giuseppe , Salvatici Elisabetta , Rovelli Valentina , Jaeken Jaak 
Published: February 2022

AbstractCongenital disorders of glycosylation (CDG) are a group of rare metabolic diseases, characterized by a defect in the protein glycosylation process. Enzymes involved in this metabolic mechanism have ubiquitous distribution; thus, their alteration can cause systemic involvement and considerable phenotypic variability. Nephrotic syndrome (NS) is a clinical condition characterized by edema, hypoalbuminemia, hyperlipidemia, and proteinuria. We hereby report the case of a girl with central hypotonia, epilepsy, and severe psychomotor delay diagnosed with phosphomannomutase 2 deficiency (PMM2‐CDG) after presenting with nephrotic syndrome at age 4 years.
REAL‐world clinical effectiveness of ivacaftor therapy in the first 24 months in two infants with cystic fibrosis and different gating mutations—A case report
Authors: Fuchs Teresa , Appelt Dorothea , Niedermayr Katharina , Ellemunter Helmut 
Published: February 2022

AbstractThis study summarizes efficacy of ivacaftor treatment in 2 infants in a real‐world setting. A distinct decline of sweat chloride and lung clearance index plus increase in fecal elastase was seen. The results underline the early and sustainable effect and give cause for discussing whether a reduction in standard cystic fibrosis therapy is possible.
Cutaneous diphtheria complicated oncologic reconstruction surgery in osteosarcoma
Authors: Abdolkarimi Babak , Amanati Ali , Bahoush Mehdiabadi Gholamreza 
Published: February 2022

AbstractDiphtheria is an uncommon bacterial infection of the upper respiratory tract. We described a surgical site infection in a young adolescent female on maintenance chemotherapy. Corynebacterium diphtheriae was recovered from the wound, and she was treated with antibiotics and antitoxin. Cutaneous diphtheria should be considered in immunocompromised patients receiving chemotherapy.
Clinical response in metastatic castration‐resistant prostate cancer (mCRPC) cases treated with supra‐physiological doses of testosterone: Bipolar androgen therapy
Authors: Hoshi Senji , Bilim Vladimir , Hoshi Kiyotsugu , Nakagawa Takuya , Sato Sadanobu , Sakagami Rie , Konno Masato , Kudo Takashi , Numahata Kenji , Sasagawa Isoji 
Published: February 2022

AbstractAndrogen deprivation therapy is a standard of care for metastatic prostate cancer. A paradoxical approach utilizing high doses of testosterone in castration‐resistant prostate cancer patients demonstrated clinical responses. Here, we report on four heavily pretreated Japanese patients (including one patient on hemodialysis) successfully treated with supra‐physiological doses of testosterone.
Utilization of Silver Silicate for the Formation of Highly Dispersed Silver on Silica Catalysts
Authors: Keijzer Petra H. , de Jongh Petra E. , de Jong Krijn P. 
Published: February 2022

AbstractSupported silver catalysts with small and uniform particle sizes are promising for selective hydrogenation or oxidation reactions. However, during catalyst preparation, transport of the silver precursors often leads to large silver particles, especially at higher silver loadings. In this paper, the use of silver silicate as an intermediate for the preparation of silica‐supported silver nanoparticles is reported. Supported silver silicate was prepared by reacting silver nitrate with silica. Subsequently, the silver silicate was reduced to prepare supported silver nanoparticles of ∼2 nm in size at a loading of 15 wt% Ag. The utilization of silver silicate limited the transport of silver species during precursor decomposition, resulting in silver nanoparticles 20 times smaller than those formed by direct reduction of a supported silver nitrate precursor. The catalysts were applied in carbon monoxide oxidation, which confirmed the high dispersion as well as the excellent stability of the supported silver nanoparticles thus prepared.
Solidified and Immobilized Heteropolyacids for the Valorization of Lignocellulose
Authors: Hombach Lea , Simitsis Natalia , Vossen Jeroen Thomas , Vorholt Andreas J. , Beine Anna Katharina 
Published: February 2022

AbstractHeteropolyacids have been identified as promising for catalyzing the reaction types, hydration and dehydration, which play an important role in the valorization of lignocellulose. Not only do they possess adaptable Brønsted acidity, but they also show a redox multi functionality. To increase the industrial applicability of this promising class of catalysts and to enable recycling, many different approaches for immobilization (such as multiphasic catalysis or grafting) and solidification (such as salt formation) have been pursued in recent years. This review summarizes these efforts and highlights the studied acid‐catalyzed lignocellulose conversions, trends and current challenges.
Elucidating Ru Distribution State of Ru‐Promoted Pr2Sn2O7 Pyrochlore and its Effect on the Catalytic Performance for Toluene Deep Oxidation
Authors: Liu Jianjun , Zeng Lanling , Xu Xianglan , Xu Junwei , Fang Xiuzhong , Bian Yijun , Wang Xiang 
Published: February 2022

AbstractTo obtain applicable catalysts for toluene combustion, Ru‐promoted Pr2Sn2O7 has been prepared with impregnation (Ru/Pr2Sn2O7) and hydrothermal method (Ru−Pr2Sn2O7). For the two Ru/Pr2Sn2O7 catalysts, Ru scatters on the surface of Pr2Sn2O7 as both metallic Ru and RuO2. In contrast, for the two Ru−Pr2Sn2O7 catalysts, Ru is substituted into Pr2Sn2O7 lattice as Ru4+. The distribution states of Ru affect significantly the active surface oxygen amount and the toluene adsorption capacity, which are the two major reasons influencing the reactivity. On Ru/Pr2Sn2O7, a greater quantity of active oxygen sites can be formed than on Ru−Pr2Sn2O7. Furthermore, the presence of surface Ru0 facilitates also toluene adsorption. As a consequence, the intrinsic activity of the two Ru/Pr2Sn2O7 catalysts are much higher than the two Ru−Pr2Sn2O7 catalysts. It is concluded that supporting Ru on Pr2Sn2O7 surface is a better way than doping Ru into its lattice to fabricate more active and applicable catalysts.
Refractories from fire to fire
Authors: Rigaud Michel , Poirier Jacques 
Published: February 2022

AbstractA brief description of the evolution of the making and usage of crucible and heat containing linings to the development of today eco‐designed refractories materials is offered to illustrate the gigantic steps the refractory constituency has accomplished. Eco for Ecological, Economical, Eco‐Energetical. That is fire to FIRE.To prolong Professor T. Planje's vision, the research and education needs are to be secured. This will require unified efforts of all stakeholders of our brotherhood. A brief description of FIRE's role for such a purpose is hence recalled, insisting on the implementation of the conception, design, implementation, organization approach to support the refractory industry needs for young innovators.
Investigating a Boronate‐Affinity‐Guided Acylation Reaction for Labelling Native Antibodies
Authors: Adak Avijit K. , Huang Kuan‐Ting , Liao Chien‐Yu , Lee Yuan‐Jung , Kuo Wen‐Hua , Huo Yi‐Ren , Li Pei‐Jhen , Chen Yi‐Ju , Chen Bo‐Shiun , Chen Yu‐Ju , Chu Hwang Kuo , Wayne Chang Wun‐Shang , Lin Chun‐Cheng 
Published: February 2022

AbstractThe excellent molecular recognition capabilities of monoclonal antibodies (mAbs) have opened up exciting opportunities for biotherapeutic discovery. Taking advantage of the full potential of this tool necessitates affinity ligands capable of conjugating directly with small molecules to a defined degree of biorthogonality, especially when modifying natural Abs. Herein, a bioorthogonal boronate‐affinity‐based Ab ligand featuring a 4‐(dimethylamino)pyridine and an S‐aryl thioester to label full‐length Abs is reported. The photoactivatable linker in the acyl donor facilitated purification of azide‐labelled Ab (N3‐Ab) was quantitatively cleaved upon brief exposure to UV light while retaining the original Ab activity. Click reactions enabled the precise addition of biotin, a fluorophore, and a pharmacological agent to the purified N3‐Abs. The resulting immunoconjugate showed selectivity against targeted cells. Bioorthogonal traceless design and reagentless purification allow this strategy to be a powerful tool to engineer native antibodies amenable to therapeutic intervention.
Capture of Gaseous Iodine in Isoreticular Zirconium‐Based UiO‐n Metal‐Organic Frameworks: Influence of Amino Functionalization, DFT Calculations, Raman and EPR Spectroscopic Investigation
Authors: Leloire Maeva , Walshe Catherine , Devaux Philippe , Giovine Raynald , Duval Sylvain , Bousquet Till , Chibani Siwar , Paul Jean‐Francois , Moissette Alain , Vezin Hervé , Nerisson Philippe , Cantrel Laurent , Volkringer Christophe , Loiseau Thierry 
Published: February 2022

AbstractA series of Zr‐based UiO‐n MOF materials (n=66, 67, 68) have been studied for iodine capture. Gaseous iodine adsorption was collected kinetically from a home‐made set‐up allowing the continuous measurement of iodine content trapped within UiO‐n compounds, with organic functionalities (−H, −CH3, −Cl, −Br, −(OH)2, −NO2, −NH2, (−NH2)2, −CH2 NH2) by in‐situ UV‐Vis spectroscopy. This study emphasizes the role of the amino groups attached to the aromatic rings of the ligands connecting the {Zr6O4(OH)4} brick. In particular, the preferential interaction of iodine with lone‐pair groups, such as amino functions, has been experimentally observed and is also based on DFT calculations. Indeed, higher iodine contents were systematically measured for amino‐functionalized UiO‐66 or UiO‐67, compared to the pristine material (up to 1211 mg/g for UiO‐67‐(NH2)2). However, DFT calculations revealed the highest computed interaction energies for alkylamine groups (−CH2NH2) in UiO‐67 (−128.5 kJ/mol for the octahedral cavity), and pointed out the influence of this specific functionality compared with that of an aromatic amine. The encapsulation of iodine within the pore system of UiO‐n materials and their amino‐derivatives has been analyzed by UV‐Vis and Raman spectroscopy. We showed that a systematic conversion of molecular iodine (I2) species into anionic I− ones, stabilized as I−⋅⋅⋅I2 or I3− complexes within the MOF cavities, occurs when I2@UiO‐n samples are left in ambient light.
Helical Chiral N‐Heterocyclic Carbene Ligands in Enantioselective Gold Catalysis
Authors: Pallova Lenka , Abella Laura , Jean Marion , Vanthuyne Nicolas , Barthes Cécile , Vendier Laure , Autschbach Jochen , Crassous Jeanne , Bastin Stéphanie , César Vincent 
Published: February 2022

AbstractThe first chiral helicene‐NHC gold(I) complexes efficient in enantioselective catalysis were prepared. The L‐shaped chiral ligand is composed of an imidazo[1,5‐a]pyridin‐3‐ylidene (IPy) scaffold laterally substituted by a configurationally stable [5]‐helicenoid unit. The chiral information was introduced in a key post‐functionalization step of a NHC‐gold(I) complex bearing a symmetrical anionic fluoreno[5]helicene substituent, leading to a racemic mixture of complexes featuring three correlated elements of chirality, namely central, axial and helical chirality. After HPLC enantiomeric resolution, X‐ray crystallography and theoretical calculations enabled structural and stereochemical characterization of these configurationally stable NHC‐gold(I) complexes. The high potential in asymmetric catalysis is demonstrated in the benchmark cycloisomerization of N‐tethered 1,6‐enynes with up to 95 : 5 er.
A porosity model for medical image segmentation of vessels
Authors: Goodarzi Ardakani Vahid , Gambaruto Alberto M. , Silva Goncalo , Pereira Ricardo 
Published: February 2022

AbstractA physics‐based medical image segmentation method is developed. Specifically, the image greyscale intensity is used to infer the voxel partial volumes and subsequently formulate a porous medium analogy. The method involves first translating the medical image volumetric data into a three‐dimensional computational domain of a porous material. A velocity field is then obtained from numerical simulations of incompressible fluid flow in the porous material, and finally a velocity iso‐surface provides the surface description of the target object. The approach is tested on CT images of eight patient‐specific cases, where cerebral aneurysms, nasal cavities (NC), and an aortic arch (AA) are the objects of interest. In the aneurysm cases, the results are compared against constant greyscale thresholding and manual segmentation. The manual segmentations of the aneurysms are validated by a clinical practitioner. Only a qualitative comparison is available for the NC, and the AA geometries. The results show that the proposed method is effective and capable of extracting the target object in a noisy domain. A sensitivity study is carried out to verify the method's performance with respect to modelling or user choices. The segmentation by the proposed method is also evaluated by performing computational fluid dynamics simulation, including a near‐wall flow analysis, to ensure that the segmented geometry and the resulting computed solution are representative and meaningful.