bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of ursolic acid niosomes with chitosan coating for prevention of liver damage in mice induced by n-nitrosodiethylamine
Authors: Miatmoko Andang , Faradisa Amelia Anneke , Jauhari Achmad Aziz , Hariawan Berlian Sarasitha , Cahyani Devy Maulidya , Plumeriastuti Hani , Sari Retno , Hendradi Esti 
Published: December 2022

AbstractUrsolic acid (UA) is a pentacyclic triterpene carboxylic acid which produces various effects, including anti-cancer, hepatoprotective, antioxidant and anti-inflammatory. However, UA demonstrates poor water solubility and permeability. Niosomes have been reported to improve the bioavailability of low water-soluble drugs. This study aimed to investigate the protective action of UA-niosomes with chitosan layers against liver damage induced by N-Nitrosodiethylamine (NDEA). UA niosomes were prepared using a thin layer hydration method, with chitosan being added by vortexing the mixtures. For the induction of liver damage, the mice were administered NDEA intraperitoneally (25 mg/kgBW). They were given niosomes orally (11 mg UA/kgBW) seven and three days prior to NDEA induction and subsequently once a week with NDEA induction for four weeks. The results showed that chitosan layers increased the particle sizes, PDI, and ζ-potentials of UA niosomes. UA niosomes with chitosan coating reduced the SGOT and SGPT level. The histopathological evaluation of liver tissue showed an improvement with reduced bile duct inflammation and decreasing pleomorphism and enlargement of hepatocyte cell nuclei in UA niosomes with the chitosan coating treated group. It can be concluded that UA niosomes with chitosan coating improved the efficacy of preventive UA therapy in liver-damaged mice induced with NDEA.
Intraglandular mesenchymal stem cell treatment induces changes in the salivary proteome of irradiated patients
Authors: Lynggaard Charlotte Duch , Jersie-Christensen Rosa , Juhl Morten , Jensen Siri Beier , Grønhøj Christian , Melchiors Jacob , Jacobsen Søren , Møller-Hansen Michael , Herly Mikkel , Ekblond Annette , Kastrup Jens , Fischer-Nielsen Anne , Belstrøm Daniel , von Buchwald Christian 
Published: December 2022

Abstract
Background
Hyposalivation and xerostomia (dry mouth), are the leading site-effects to treatment of head and neck cancer. Currently, there are no effective therapies to alleviate radiation-induced hyposalivation. Adipose tissue-derived mesenchymal stem/stromal cells (AT-MSCs) have shown potential for restoring salivary gland function. However, the mode of action is unknown. The purpose of the present study was therefore to characterize the effect of AT-MSC therapy on the salivary proteome in previously irradiated head and neck cancer patients.

Methods
Whole saliva was collected from patients with radiation-induced salivary gland hypofunction (n = 8) at baseline, and 120 days after AT-MSC treatment, and from healthy controls (n = 10). The salivary proteome was characterized with mass spectrometry based proteomics, and data was compared within the AT-MSC group (baseline versus day 120) and between AT-MSC group and healthy controls. Significance levels between groups were determined by using double-sided t-test, and visualized by means of principal component analysis, volcano plots and cluster analysis.

Results
Here we show that 140 human proteins are significantly differentially expressed in saliva from patients with radiation-induced hypofunction versus healthy controls. AT-MSC treatment induce a significant impact on the salivary proteome, as 99 proteins are differentially expressed at baseline vs. 120 days after treatment. However, AT-MSC treatment does not restore healthy conditions, as 212 proteins are significantly differentially expressed in saliva 120 days after AT-MSCs treatment, as compared to healthy controls.

Conclusion
The results indicate an increase in proteins related to tissue regeneration in AT-MSCs treated patients. Our study demonstrates the impact of AT-MSCs on the salivary proteome, thereby providing insight into the potential mode of action of this novel treatment approach.
Compact Ka‐band conical beam filtenna
Authors: Shi‐Shan Qi , Keren Zhu , Wen Wu 
Published: December 2022

AbstractA compact conical beam antenna composed by a filtering power divider (FPD) and circular open waveguide is presented. In order to reduce insertion loss in Ka‐band, the five‐way radial power divider and the cascaded filters are constructed using metallic waveguides. The filter is based on the principle of the magnetic field inversion characteristics of higher‐order mode resonances, using TE101 and TE102 over‐mode bypass coupling to create a pair of transmission zeros around the passband. A more compact folded structure is obtained by placing adjacent cavities back‐to‐back. Finally, TM01 mode on the circular aperture is excited by the output of the FPD, realising a conical beam radiation pattern. This proposed antenna works at the central frequency of 35 GHz, the maximum elevation angle of θ = 20° and the measured gain of 7.83 dBi have been achieved. The results shows that the impedance bandwidth is 6.29%, from 33.85 to 36.05 GHz. In terms of miniaturisation, the size of the entire antenna is 3.85λ02.51λ0.
Non‐local low‐rank constraint‐based self‐consistent PMRI reconstruction using eigenvector maps
Authors: Duan Jizhong , Pan Ting , Liu Yu , Wang Junfeng 
Published: December 2022

AbstractEigenvector‐based SPIRiT (ESPIRiT) can estimate multiple sets of coil sensitivity maps from the calibration matrix constructed from the auto‐calibration data. Recently, the L1 norm and total variation were combined with the ESPIRiT model to improve the reconstruction quality of magnetic resonance (MR) images. To further improve the reconstruction performance, the non‐local low‐rank regularisation term is incorporated into the ESPIRiT model (NLR‐ESPIRiT) is proposed. The proposed NLR‐ESPIRiT model takes full advantage of the non‐local self‐similarity features of MR images. The resulting optimisation problem can be transformed into a gradient problem and a denoising problem with low‐rank constraints using the operator splitting technique. The weighted nuclear norm (WNN) is applied as a surrogate of the rank. Then the denoising subproblem with the WNN can be effectively solved by using the alternating direction method of multipliers technique. For practical applications, a parameter‐selecting method is proposed to obtain almost optimal parameters for the same kind of MR images. Simulation experiments on in vivo data sets demonstrate that the proposed NLR‐ESPIRiT outperforms all competing traditional model‐based algorithms in terms of three objective metrics and visual comparison.
Large Interferometer For Exoplanets (LIFE)
Authors: Hansen Jonah T. , Ireland Michael J. , Laugier Romain ,   the LIFE Collaboration
Published: December 2022

Context. In the fourth paper in this series, we identified that a pentagonal arrangement of five telescopes, using a kernel-nulling beam combiner, shows notable advantages for some important performance metrics for a space-based mid-infrared nulling interferometer over several other considered configurations for the detection of Earth-like exoplanets around solar-type stars.
Aims. We aim to produce a physical implementation of a kernel-nulling beam combiner for such a configuration, as well as a discussion of systematic and stochastic errors associated with the instrument.
Methods. We developed a mathematical framework around a nulling beam combiner, and then used it along with a space interferometry simulator to identify the effects of systematic uncertainties.
Results. We find that errors in the beam combiner optics, systematic phase errors and the root-mean-squared (RMS) fringe tracking errors result in instrument-limited performance at ~4–7 μm, and zodiacal light limited at ≳10 μm. Assuming a beam splitter reflectance error of |ΔR| = 5% and phase shift error of Δϕ = 3°, we find that the fringe tracking RMS error should be kept to less than 3 nm in order to be photon limited, and the systematic piston error be less than 0.5 nm to be appropriately sensitive to planets with a contrast of 1 × 10−7 over a 4–19 μm bandpass. We also identify that the beam combiner design, with the inclusion of a well-positioned shutter, provides an ability to produce robust kernel observables even if one or two collecting telescopes were to fail. The resulting four-telescope combiner, when put into an X-array formation, results in a transmission map with a relative signal-to-noise ratio equivalent to 80% of a fully functioning X-array combiner.
Conclusions. The advantage in sensitivity and planet yield of the Kernel-5 nulling architecture, along with an inbuilt contingency option for a failed collector telescope, leads us to recommend this architecture be adopted for further study for the LIFE mission.
Vom Problem zur Befreiung
Authors: Ennenbach Matthias 
Published: December 2022

SummaryImmer mehr Menschen öffnen sich für die östliche Philosophie und Spiritualität und wünschen sich die Aufnahme dieses universellen Bezuges und entsprechender Methoden in die psychotherapeutische Behandlung. Die buddhistische Psychotherapie geht davon aus, dass Probleme sehr stark durch unseren Verstand mitgestaltet werden, und nutzt – im Anschluss an die allen Verfahren gemeinsame Ich-Konsolidierung – die Erfahrung vom Bewusstheit und Heilsein als Motor der Selbstwirksamkeit und Befreiung. Während Körper- und Atemübungen eine Konsolidierung und Erdung bewirken, decken Methoden wie Vertiefungsmeditationen Egoanteile auf, die anschließend aufgelöst werden können.
„Ich bin nicht verrückt“
Authors: Ennenbach Matthias 
Published: December 2022

SummaryDie buddhistische Psychotherapie betrachtet Leiden nicht als Störung, sondern als Normalität, die sich annehmen und gestalten lässt – und nutzt dazu die Stufen Selbststeuerung, Egoanalyse und Problembewältigung. Im Behandlungsbeispiel leidet der Patient unter starken Angstzuständen, unter anderem in öffentlichen Verkehrsmitteln, und instabiler Hypertonie, was sich durch eine problemorientierte Psychotherapie in der Vergangenheit noch verstärkte. Im Rahmen der Behandlung erlernte der Patient Akzeptanz, Selbstwirksamkeit, Selbstbetrachtung, Atem- und Körperübungen sowie neue Gestaltungsmöglichkeiten – und überwand damit seine Hilflosigkeit.
„Eine zutiefst positive Grundhaltung“
Authors: Cicekten Alphan 
Published: December 2022

SummaryReinhard Textor hat sich als Behandelnder und Ausbildender unter anderem auf die humanistische Psychologie spezialisiert. Welche Potenziale birgt diese für den Einzelnen, aber auch für die Gesellschaft? Wie kann sie sich weiterentwickeln und den Menschen der heutigen Zeit dort abholen, wo er steht? Und weshalb lohnt sich der humanistische Blick auf den Heilpraktikerberuf und seinen Platz in der Gesellschaft?
Karl nervt
Authors: Franke Ulrike 
Published: December 2022

SummaryTheraplay® ist eine körpernahe Spieltherapie und bietet unter anderem beruhigende Rituale und anregende Spiele für das kindliche Nervensystem. Eine wichtige Ausgangsfrage der Theraplay-Begründerin Ann Jernberg ist: Was braucht das Kind, damit es ihm gut geht und es sich entwickeln kann? Anhand des Fallberichts demonstriert die Autorin, wie dem Kind Sicherheit vermittelt und es achtsam und spielerisch an die Beziehung und die therapeutische Situation herangeführt wird.
Allergologie und die Herausforderungen im aktuellen Zeitgeschehen
Authors: Tratzmiller Sabine , Klemke Claus-Detlev 
Published: December 2022

ZusammenfassungDie Versorgung allergologischer Patienten ist ein klinischer Schwerpunkt der Karlsruher
Hautklinik. Der diagnostische Fokus lag in der Vergangenheit im Nachweis von
Typ-IV-Sensibilisierungen. Jedoch ist aufgrund einer zunehmenden Nachfrage die Diagnostik von
Hymenopterengiftallergien immer mehr in den Vordergrund getreten.Die direkten Auswirkungen des aktuellen Zeitgeschehens auf die allergologische Tätigkeit
in der Karlsruher Klinik wurden aktuell im Hinblick auf die Abklärung einer potenziellen
Allergie auf einen COVID-19-Impfstoff noch spürbarer.
Geschichte der Karlsruher Hautklinik
Authors: Spahn Pascal , Klemke Claus-Detlev 
Published: December 2022

ZusammenfassungDie Geschichte der Karlsruher Hautklinik zeichnet sich bereits mit der Eröffnung eines Spitals 1788 am heutigen Lidelplatz ab. Initial eingegliedert in die zwei großen medizinischen Disziplinen Innere Medizin und Chirurgie, entwickelte sich 1907 eine eigenständige Abteilung für Haut- und Geschlechtskranke sowie nach Ende der Besatzungszeit eine eigene Hautklinik. Unter den erfahrenen Klinikdirektoren konnte die Zahl an behandelten dermatologischen Patienten stets erhöht werden und den Anforderungen einer modernen, wissenschaftlichen Klinik begegnet werden. Mit der Zertifizierung 2017 als Hauttumorzentrum hat die Klinik ihren onkologischen Schwerpunkt, neben der Behandlung konservativer Dermatosen, unterstrichen und wird sich auch in naher Zukunft durch einen geplanten Umzug in modernisierte Räumlichkeiten im Zentrum des Klinikums weiterentwickeln.
Diagnose Krebs: Wenn Ärzte schwer erkranken
Authors: Apondo Sandra , Bein Thomas , Schönhofer Bernd 
Published: December 2022

ZUSAMMENFASSUNGVordergründig betrachtet sind wir Ärzte gesunde Helfer, die Patienten kranke Hilfsbedürftige. Wir tragen den weißen Kittel, sie das Flügelhemd. Einige von uns sind selbst Patienten und wir alle haben schon kranke Ärzte behandelt. Was passiert, wenn Ärzte schwer erkranken? Wir drei krebskranke Ärzte berichten über unseren Perspektivwechsel. Unsere Erfahrungen ermöglichen uns, vom Ende her zu denken, und prägen nachhaltig unseren Blick auf die moderne Medizin.
Wieder im Hier und Jetzt
Authors: Tilmann Psych Savina 
Published: December 2022

SummaryDysregulierte Zustände wie Dissoziation, Panik und Gedankenkreisen sind nicht zwingend an psychische Störungen geknüpft, sondern in einem gewissen Umfang menschliche Normalität. Der Bodyscan, die bewusste Veränderung der Körperhaltung, der Gedankenstopp oder die 5-4-3-2-1-Methode sind bewährte Entspannungs- beziehungsweise Stabilisierungsübungen. Menschen mit dauerhaft dysreguliertem Nervensystem profitieren von Übungen, die den Vagusnerv ansprechen. „Normale“ Entspannungsbemühungen können hier sogar paradox wirken.
Ein machtvolles Werkzeug
Authors: Tilmann Psych Savina 
Published: December 2022

SummaryEin achtsamer Umgang mit Sprache in Form von adäquater Wortwahl, weichem Sprachklang etc. ist im therapeutischen oder beraterischen Kontext unerlässlich. Das Modell der Stufen des Zuhörens kann therapeutisch und beratend Arbeitenden dabei helfen, ihren Zuhör-Stil zu reflektieren und gegebenenfalls eine noch konstruktivere Haltung einzunehmen. Das 4-Ohren-Modell beschreibt menschliche Kommunikation auf 4 Ebenen (Sach-Ohr, Apell-Ohr, Beziehungsohr, Selbsterfahrungsohr) und bietet Übungen zur Differenzierung dieser.
The Mini-TRH Test
Authors: Spoov Johan 
Published: December 2022

AbstractThyrotropin-releasing hormone (TRH), at doses lower than those needed to
stimulate prolactin secretion directly, can almost completely antagonize
dopamine inhibition of prolactin release. In normal men, prolactin increases
15 min following an i. v. bolus of 12.5 µg TRH
(the mini-TRH test), but not the maximal prolactin response to TRH or basal
prolactin, positively correlated with prolactin response to haloperidol and
negatively with 24-h urinary excretion of homovanillic acid (HVA). These results
suggest that the mini-TRH test is a better estimate of dopamine inhibition of
prolactin release than the maximal prolactin response or basal prolactin level.
A recent neuroimaging study suggested that in schizophrenia, there is a widely
distributed defect in extrastriatal dopamine release, but the patients were not
in the most acute phase of psychosis. The evidence is reviewed that this defect
extends to tuberoinfundibular dopamine (TIDA) and which symptoms are associated
with the test. In patients with acute nonaffective psychosis, the mini-TRH test
positively correlated with nonparanoid delusions and memory dysfunction,
indicating decreased dopamine transmission in association with these symptoms.
In patients with acute drug-naïve first-episode schizophrenia, the
mini-TRH test negatively correlated with negative disorganization symptoms and
with basal prolactin. The latter correlation suggests the contribution of
factors related to maximal prolactin stimulation by TRH; therefore, an
alternative dose of 6.25 μg TRH could be used for the mini-TRH
test in first-episode patients, allowed by increased sensitivity of the present
prolactin tests. Future studies are needed to investigate whether the mini-TRH
test could help in finding the optimal antipsychotic medication.
Rh(II)-Catalyzed Ring Expansion of Cyclopropyl N-Tosylhydrazones to 1-Substituted Cyclobutenes
Authors: Huo Jingfeng , Wang Jianbo , Ouyang Wenbai 
Published: December 2022

AbstractCyclobutenes are highly useful synthetic intermediates as well as important motifs in functional molecules. Herein, we report a straightforward access toward monosubstituted cyclobutenes from cyclopropyl N-tosylhydrazone. 1,2-Aryl or -alkyl shift of the Rh(II) carbene intermediate plays the key role in this transformation.
Photoredox-Catalysis-Enabled Ring-Opening Functionalization of Aryl Cyclopropanes
Authors: Feng Chao , Li Zhi-Qiang , Zhang Chi 
Published: December 2022

AbstractCyclopropanes have long been recognized as privileged synthons in organic synthesis, providing access to 1,3-difunctionalized scaffolds. However, the synthetic potential of aryl cyclopropanes, one of the most important subclasses of cyclopropanes, is far less explored. Recently, we uncovered a visible-light-promoted strategy for the ring-opening functionalization of a series of aryl cyclopropanes through open-shell intermediates. By leveraging the activation of an aryl radical cation derived from an oxidative single-electron transfer, the C–C bond of the cyclopropane is weakened and cleaves upon a regio- and stereoselective nucleophilic attack with an exogenous nucleophile to provide a benzyl radical that can be readily elaborated to diverse functionalities.1	Introduction2	Core Concept of Our Design3	Photoredox-Catalyzed Oxoamination of Aryl Cyclopropanes4	Photoredox-Catalyzed Hydroheterofunctionalization of Aryl Cyclopropanes5	Photoredox-Catalyzed Fluoroallylation of gem-Difluorocyclopropanes6	Conclusion
Awake Cranioplasty in a Patient with Rheumatic Heart Disease: A Novel Approach
Authors: Depuru Aparna , Bhatia Nidhi , Bhagat Hemant , Singh Apinderpreet 
Published: December 2022

AbstractCranioplasty is a surgical procedure that restores the normal anatomy following craniectomy. Restoring the skull bone ensures protection and normalizes the physiology as well as the cerebrospinal fluid dynamics. This surgical procedure usually requires administration of general anesthesia for retrieving the bone placed in the abdominal region and thereafter placing it in the cranium. We report the anesthetic management of a high-risk case who had severe mitral stenosis and was scheduled for cranioplasty. The anesthetic management of a patient with rheumatic heart disease, with severe mitral stenosis, posted for cranioplasty, is extremely challenging. The presence of cardiac pathology necessitates the need to balance patient's hemodynamics in accordance with the cardiac grid and tests the limits of the anesthesiologist's preparedness. We describe our experience of conduct of this case in regional anesthesia using scalp block on the defect site with an oblique transverse abdominis plane block for abdominal bone retrieval.
Supralabial Site: An Alternative Site for Bispectral Index Monitoring: A Cross-sectional Study
Authors: Dubey Jitendra K. , Goel Nitesh , Chawla Rajiv , Gupta Manish , Bhardwaj Manoj 
Published: December 2022

Abstract
Background Bi-spectral index (BIS) has been traditionally used to monitor the depth of anesthesia, with the forehead being the usual site for electrode placement. When the manufacturer-recommended site is itself an operative field or the placement interferes with the surgery, the search for an alternative position of electrode placement is warranted. In our endeavor to do so, we conducted this study to compare BIS scores derived from frontal and supralabial electrode placement.
Methods A cross-sectional study was conducted on a group of 50 patients using two BIS Quatro sensors attached to the frontal and supralabial regions of each patient and connected to two different sets of monitors. BIS values, electromyography (EMG) values, and signal quality index (SQI) were noted from both sites every 15 min during the maintenance phase of anesthesia. Collected data were analyzed using the Bland–Altman analysis.
Results Data analysis of BIS values showed negative bias at most time points with a minimum negative bias of 0.2 with a limit of agreement of −3.67/3.27 and a maximum negative bias of 1.14 with a limit of agreement of −7.61/5.33. The overall 95% limit of agreement for pooled BIS data ranged from −6.63 to 6.1.
Conclusion BIS sensor placement at the supralabial site can be used as an alternative to the frontal placement in scenarios where the frontal position is the surgical site or is inaccessible during the maintenance of general anesthesia as in neurosurgery with particular emphasis on skin preparation and proper positioning of BIS electrodes to improve the signal quality.
Use of Telemedicine in Evaluation of Pediatric Surgical Patients in COVID-19 Time
Authors: Rai Rahul Kumar , Pandey Anand , Gupta Archika , Singh Gurmeet , Rawat Jiledar 
Published: December 2022

Objective
The word “telemedicine” literally translates to “healing at a distance.” In the current scenario of the coronavirus disease 2019 (COVID-19) pandemic and shut outpatient department, the patients are facing difficulty in consultation. This article evaluated the use of telemedicine in the management of pediatric surgical patients.

Materials and Methods
In this observational cohort study, from April 2020 to August 2020, all patients who took advice on phone/WhatsApp were assessed for addressing their complaints. The data was collected and analyzed.

Result
A total of 307 patients were provided consultation via telecommunication. The male to female ratio was 2.3:1. Fifty-six (18.2%) patients called on an emergency basis, while the remaining 251 (81.8%) patients called for nonemergency or routine problems. Of these, attendants of 25 (8.14%) patients were not able to state the situation adequately. They were called to the department. Of these, 11 (3.5% of total) patients were admitted. One-hundred and eighty-three (59.6%) patients were in the department's follow-up, while the remaining 124 (40.4%) were new patients. The attendants of 296 (96.4%) patients were satisfied by using this modality of consultation.

Conclusion
In the current scenario, telecommunication may help us to avoid unnecessary travel to the hospital. It may be helpful to deal with minor clinical complaints and evaluating for an emergency.
Ileocolic Anastomoses
Authors: Gleason Lauren , Gunnells Drew 
Published: December 2022

AbstractIleocolic anastomoses are commonly performed by surgeons in both open and minimally invasive settings and can be created by using many different techniques and configurations. Here the authors review both current literature and the author's preference for creation of ileocolic anastomoses in the setting of malignancy, inflammatory bowel disease, and colonic inertia. The authors also review evidence surrounding adjuncts to creation of anastomoses such as use of indocyanine green and closing mesenteric defects. While many techniques of anastomotic creation have adapted with new evidence and technologies, several key principles still provide the foundation for current practice.