bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optoelectronic properties of C 66 H 54 Br 6 N 6 O 12 supramolecular nanotube by DFT studies
Authors: Aliabad H. A. Rahnamaye , Vahidi H. 
Published: June 2022

Abstract
In this work, the structural and optoelectronic properties of C66H54Br6N6O12 nanotubes, which is in the triclinic phase, have been studied by the Perdew- Burke- Ernzrhof Generalized Gradient Approximation (PBE- GGA). The semi metallic behaviors and the flat bands are observed in the band structure with 2.06 eV band gap. From the optical spectra, this nanotube is birefringence with Plasmon energies of 23.41, 23.36 and 23.55 eV at x, y and z direction, respectively. Cauchy coefficients have been obtained in the wavelength range of 550 to 850 nm. The results show that this nanotube cab be used in the optoelectronic devices like metallic carbon nanotube and glasses.
Intratumoral Heterogeneity of CRC Revealed by Single-Cell Transcriptome Analysis, which Results in Poor Prognosis Clinical Outcomes
Authors: Lu Tianyu , Liu Shiying , Tao Quyuan , Xu Zewen , Zhao Tingxiu , Jin He , Zhu Shuang , Han Xue , Luo Jianfeng , Zhong Jiamin , Chen Xin-lin , Li Haiwen , Wang Yumei 
Published: June 2022

Abstract
Background: Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. Its pathogenesis is complex and involves abnormalities of malignant cells and tumor microenvironment (TME). The characteristics of malignant cells and TME based on single cells are unknown. This study aimed to deeply understand the intratumoral heterogeneity of CRC, and to identify cell subclusters associated with poor prognosis.Methods: scRNA-seq analyses of the CRC patients were performed. Cell subclusters of TME (immune cells and stromal cells) and malignant cells were identified. Immune Checkpoint analysis, functional enrichment analysis, SCENIC analysis, pseudotime trajectory analysis and intercellular signal communication analysis were utilized to explore the characteristics of intratumoral heterogeneity. The correlation of cell subclusters and the prognosis of CRC patients were explored using the transcriptome sequencing data of CRC from The Cancer Genome Atlas (TCGA) database.Results: A total of 11 major cell types and 18 cell subclusters were identified. Malignant cells exhibited abnormal metabolic patterns, in which the leptin signaling pathway was downregulated and the arachidonic acid metabolic pathway was upregulated. Macrophages exhibited M2 polarization. TREM2 and SPP1 genes were highly expressed in tumor-associated macrophages (TAMs). CD8+ T cells tend to be exhausted. Based on the fraction of each cell cluster, TAMs, exhausted CD8+ T cells and myo-cancer-associated fibroblasts (mCAFs) were associated with a poor prognosis. The patients from the TCGA COAD-READ were divided into 3 groups. The patients in Group 2, which showed a higher proportion of exhausted CD8+ T cells, had a poor prognosis. Conlusions: There were heterogeneity in malignant cells and TME of CRC. TAMs, exhausted CD8+ T cells and mCAFs were closely related to the poor prognosis of CRC.
Experimental research on the physical and mechanical properties and freeze-thaw resistant performance of rice straw-mortar composite materials
Authors: Zhao Rongfei , Qin Yan , Yi Xinyan , Zhang Huaqian , Gao Wei 
Published: June 2022

Abstract
Straw has relatively high tensile strength, as a kind of aggregate, combined with cement, gypsum and other bonding materials, which can improve the strength of the benchmark materials and control the initiation and propagation of microcracks. The physical and mechanical properties of straw-mortar composite materials are determined by the property of straw itself, the bonding capacity of matrix materials, the environment and other factors. In this study, three-factor and three-level regression analysis experiment was carried out by using Design-Expert software to obtain the optimal physical and mechanical properties and mix ratio of rice straw-mortar composite materials. The highest compressive strength, dry density and the lowest water absorption rate of rice straw-mortar composite materials were 3.06 MPa, 1.340 g·cm-3 and 20.8%, respectively, and the corresponding gypsum content, straw length, and straw content were 15%, 20 mm, and 15%, respectively. After 15 times freeze-thaw (F-T) between − 20 ℃ and 20 ℃, the strength loss rate, mass loss rate and water absorption rate of rice straw-mortar composites produced in different conditions varied from 32.2–47.3%, from 2.1–4.5%, and from 22.6–42.2%, respectively. The above experimental results indicated that the rice straw-mortar composite materials could meet the actual using demand of self-bearing wall whether to experience F-T, which laid a certain foundation for the popularization and application of rice straw-mortar composite materials in non-bearing wall.
First description of foetus of giant manta ray foetus Mobula birostris (Walbaum 1792) from Kochi, Kerala, Southwest India (North East Arabian Sea)
Authors: NAIR REKHA , Nair Vishnu , kts Sunil , km vishnupriya , at Sangeetha , S Pakirimuthu 
Published: June 2022

Abstract
Giant Manta Ray is assessed as Vulnerable by IUCN and has a very low reproductive capacity. India is also one of the major manta fishing countries; however, commerce in gill plates is not well documented. With information of these gentle giants scanty in literature, record of morphological and morphometric data pertaining to Mobula foetus from this region is very important. The disc length (DL) of the foetus recorded in Kochi was only 30 mm and the foetus already had pigmentation patterns in the ventral portion of the cephalic horn and displayed the presence of an umbilical attachment. The presence of the gravid female is not a solitary event and there are many such cases which may have gone unnoticed. Together with our recent findings, and previous records, this data reinforces the importance of the west coast as potential reproduction grounds for M. birostris. This information is crucial for the establishment and progression of conservation measures for this migratory species.
Comparison of time-varying recurrence patterns in breast cancer patients with different molecular subtypes treated from 2008 to 2012 and from 2013 to 2016: a single-center retrospective study
Authors: Zhou Xu-jie , Sang Yu-ting , Chen Jia-jian , Mo Miao , Hou Jian-jing , Yang Ben-long , Wu Jiong 
Published: June 2022

Abstract
Purpose: To compare the time-varying recurrence patterns of different molecular subtypes of breast cancer in the contemporary era with those in the past era. Methods: This retrospective study included 14627 consecutive invasive breast cancer patients who underwent surgery from 2008 to 2016 at Fudan University Shanghai Cancer Center. We defined the period from 2013 to 2016 as the contemporary era and that from 2008 to 2012 as the past era. Five subtypes were defined according to the immunohistochemistry results. Emphasis was made on the changing patterns of recurrence for patients with different molecular subtypes changed between the two treatment eras. Kaplan–Meier survival curves were generated, and the hazard function was used to estimate the annual recurrence hazard. Results: By the end of follow-up (median, 68.1 months), 1429 patients (9.77%) experienced recurrence and metastasis. The annual recurrence risks of the entire population and each molecular type in 2013-2016 were reduced compared with those in 2008-2012. Luminal A and triple-negative patients in 2013-2016 showed a significantly lower recurrence hazard curve than those in 2008-2012. The recurrence hazard curve of luminal B (HER2-) and HER2+ subtypes was lower in 2013-2016 than in 2008-2012. The recurrence risk of the luminal B (HER2+) subtype was reduced substantially during 2013-2016, showing a delay of two years.Conclusion: With early detection of disease recurrence and improved treatment strategies, the recurrence patterns of different molecular subtypes of breast cancer have changed. The time-varying recurrence patterns observed during the contemporary era are significant for treatment decision-making and clinical trial planning.
3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering
Authors: N’Gatta Kanga Marius , Belaid Habib , Assanvo Edja Florentin , Kajdan Marilyn , Masquelez Nathalie , Boa David , Cavaillès Vincent , Bechelany Mikhael , Salameh Chrystelle 
Published: June 2022

Abstract
Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties. Herein, we fabricated using fused deposition modelling (FDM) technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii (FT). Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm. Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%). The mineralization process of printed scaffolds using simulated body fluid was validated and nucleation of hydroxyapatite confirmed. Additionally, cytocompatibility tests revealed that PLA and PLA/CNC scaffolds are non-toxic and compatible with bone cells. Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
Effect of age and prior COVID-19 on BBIBP-CorV (Sinopharm) vaccination- induced antibody responses in a region with high seroprevalence
Authors: Hasan Zahra , Masood Kiran Iqbal , Qaiser Shama , Khan Erum , Hussain Areeba , Ghous Zara , Khan Unab , Hassan Imran , Yameen Maliha , Memon Haris Ali , Ali Shiza , Balouch Sadaf , Nasir Muhammad Imran , Qazi Muhammad Farrukh , Veldhoen Marc , Simas J Pedro , Bhutta Zulfiqar A , Mahmood Syed Faisal , Hussain Rabia , Ghias Kulsoom 
Published: June 2022

Abstract
Introduction
Sinopharm (BBIBP-CorV) inactivated virus vaccination for COVID-19 has been administered widely in Pakistan. We investigated the dynamics of BBIBP-CorV -induced antibody responses over a 24 week period in a region with a high seroprevalence.
Methods
Study subjects (n = 312) were followed up over a 24-week period between May and August 2021. Sera were tested for IgG antibodies to spike and the receptor binding domain (RBD).
Results
Study subjects were 62% female. Twenty-two percent had a prior history of COVID-19. At 4-, 8- 16- and 24-weeks post-vaccination, the rate of IgG antibodies positive to spike was 57%, 87%, 66% and 90% of individuals, compared with to RBD which was 48%, 62%, 68% and 85% of subjects, respectively,. IgG to spike and RBD showed a positive correlation at each interval (rho > 0.6, p < 0.0001). Seropositivity to both spike and RBD was reduced in those aged 50 years and over for up until 16 weeks post-vaccination (p < 0.05). Individuals with prior COVID-19 infection showed greater antibody responses for up to 16 weeks post-vaccination (p < 0.05). SARS-CoV-2 infections were observed with a mean interval of 16 weeks post-vaccination. Antibody responses did not wane for up to 6 months post-vaccination.
Conclusions
Sinopharm vaccination-induced antibody responses were negatively impacted by age and positively impacted by prior COVID-19 for 16 weeks after vaccination. Importantly, we did not find waning of IgG antibodies to RBD over the study period. Maintenance of antibodies may be the result of continued community exposure and boosting with COVID-19 vaccination.
Early prediction of prostate cancer risk in younger men using polygenic risk scores and electronic health records
Authors: Varma Amita , Maharjan Jenish , Garikipati Anurag , Hurtado Myrna , Shokouhi Sepideh , Mao Qingqing 
Published: June 2022

Abstract
Background
Prostate cancer (PCa) screening is not routinely conducted in men 55 and younger, although this age group accounts for more than 10% of cases. Polygenic risk scores (PRSs) and patient data applied towards early prediction of PCa may lead to earlier interventions and increased survival. We have developed machine learning models to predict PCa risk in men 55 and under using PRSs combined with patient data.
Methods
We conducted a retrospective study on 91,106 male patients aged 35 to 55 using the UK Biobank database. Five gradient boosting models were developed and validated utilizing routine screening data, PRSs, additional clinical data, or combinations of the three.
Results
Combinations of PRSs and patient data outperformed models that utilized PRS or patient data only, and the highest performing models achieved an area under the receiver operating characteristic curve of 0.788. Our models demonstrated a substantially lower false positive rate (35.4%) in comparison to standard screening using prostate specific antigen (60–67%).
Conclusion
This study provides the first preliminary evidence for the use of PRSs with patient data in a machine learning algorithm for PCa risk prediction in men 55 and under for whom screening is not standard practice.
Effect of Atriplex halimus extract as a biostimulant on physiological and biochemical regulation in faba bean plants.
Authors: ENNOURY Abdelhamid , roussi zoulfa , nhhala Nada , zouaoui Zakia , kabach Imad , Krid Azzouz , kchikich Anass , Nhiri Mohamed 
Published: June 2022

Abstract
This study investigated the effect of Atriplex halimus extract on faba bean plants (Vicia faba). Three different concentrations (0.1% 0.25%, and 0.5%) of Atriplex halimus extract were applied. The obtained results indicated that the tested extract had a positive effect on several physiological and biochemical parameters of the tested plants, which led to enhancing their growth. A significant (p < 0.05) increase in plant metabolites and photosynthetic pigments content was observed in the treated plants. Furthermore, Atriplex halimus extract significantly improved the activities of enzymes involved in the activation of the carbon-nitrogen enzymatic system; including, phosphoenolpyruvate carboxylase (EC 4.1.1.31), isocitrate dehydrogenase (EC 1.1.1.42), Glutamine Synthase (EC 6.3.1.2) glutathione-S-transferase (EC 2.5.1.18), glutathione reductase (EC 1.8.1.7). This effect was more pronounced in plants treated with 0.25% of Atriplex halimus extract. Altogether, our results suggest that the application of the tested extract could be used as a promising plant growth biostimulant to improve faba bean plants’ growth and yield.
Relevance of ABC Transporters in Drug Development
Authors: Nwabufo Chukwunonso K. 
Published: June 2022

Abstract:
ATP-binding cassette (ABC) transporters play a critical role in protecting vital organs such as the brain
and placenta against xenobiotics, as well as in modulating the pharmacological and toxicological profile of several
drug candidates by restricting their penetration through cellular and tissue barriers. This review paper describes the
structure and function of ABC transporters as well as the role of P-glycoprotein, multidrug resistance-associated
protein 2 and breast cancer resistance protein in the disposition of drugs. Furthermore, a review of the in vitro and
in vivo techniques for evaluating the interaction between drugs and ABC transporters is provided.
Neonatal and Maternal Outcomes of Insulin Detemir versus Neutral Protamine
Hagedorn for Diabetes Mellitus in Pregnancy
Authors: Bugazia Seif , Boshnaf Mohamed , Elbahnasawy Mohammad , Shehata Mostafa , Alqatati Fadel , Ragab Khaled Mohamed , Elsnhory Ahmed Bostamy , Elsayed Sarah Makram , Fathy Mustafa Ali , Nourelden Anas Zakarya 
Published: June 2022

Background and objectives:
Diabetes in pregnancy can lead to severe neonatal and maternal adverse events. Moreover, there is an increase in GDM prevalence. Therefore, we aimed to compare insulin detemir (IDet) with the neutral protamine Hagedorn (NPH) in diabetic pregnant women.

Methods:
We searched four electronic databases until August 2021: PubMed, Scopus, Web of Science, and Cochrane. We included randomized controlled studies that compared IDet with NPH in diabetic pregnant women. We extracted both maternal and neonatal outcomes, and used RevMan software to conduct the analysis.

Results:
A number of five studies were included. The analysis showed a significantly lower risk of hypoglycemic events during pregnancy in the IDet group than the NPH group [RR=0.6, 95% CI [0.43, 0.84], p=0.003], and a higher gestational age (GA) at delivery in the IDet group than the NPH group [MD= 0.28, 95% [0.02, 0.55], p=0.03]. On the other hand, the analysis revealed non-significant differences between IDet and NPH in terms of birth weight, congenital anomalies, neonatal hypoglycemia, preterm delivery, and others.

Conclusion:
Insulin detemir (IDet) was preferred over neutral protamine Hagedorn (NPH) in terms of showing lower rates of hypoglycemic events during pregnancy and a higher gestational age at delivery. Meanwhile, there were non-significant variations between them when it comes to neonatal outcomes, such as weight at birth, congenital anomalies, or neonatal hypoglycemia.
Introduction of Accurate Measurement of the Alveolar Bone Height in
Bone Grafting Area after Sinus Lift
Authors: Yu Yuehai , Xu Yan , Sun Jin , Xu Yao 
Published: June 2022

Background:
Sinus lift via the alveolar crest approach has been proven to solve inadequate
alveolar bone height perfectly in the posterior region of the maxilla. Nevertheless, the surgical area
cannot be directly observed, imaging methods are necessary to reveal whether the surgery has
achieved the expected results. Cone-Beam Computed Tomography (CBCT) images are usually taken
before surgery and at the completion of final pre-repair osseointegration and evaluate the effect of
maxillary sinus lift by measuring the alveolar bone height in the bone graft area. However, there is no
uniform and recognized method to accurately measure the alveolar bone height in the bone grafting
area before and after maxillary sinus lift. Therefore, the authors propose a simple, accurate, and reproducible
method for the measurement of alveolar bone height in maxillary sinus lift on CBCT, which
will be an innovation.

Methods:
30 implant cases (30 patients) were included in this study. The authors create a uniformed
measurement surface in the CBCT axial interface to ensure consistency at the completion of final prerepair
osseointegration and before surgery. Then changes in alveolar bone height in the bone grafting
area before and after sinus lift were measured on CBCT coronal and arch planes. Finally, for the purpose
of verification of repeatability, three dentists from our department were randomly selected to
measure and record the above CBCT data at three different time points.

Results:
The data showed that in the CBCT measurements of the three dentists, neither the coronal
plane nor the arch plane was statistically significant. (P > 0.05).

Conclusion:
This measurement method is simple, accurate and repeatable. It can be applied to measure
alveolar bone height in the bone grafting area before and after maxillary sinus lift.
Advanced Plasmonic Nanosensors for Monitoring of Environmental Pollutants
Authors: Denizli Adil , Çimen Duygu , Bereli Nilay 
Published: June 2022

Background:Water is polluted day by day with biological and chemical toxins that can pose a serious threat to human health, animals and ecosystems. The regular identification and monitoring of biological and chemical toxins in water resources is the first step of the preventive method. The devices used in traditional detection methods such as adsorption and chromatography combined with mass spectrometry are not easy to transport for analysis and involve laborious preliminary sample preparation steps. However, the developments in nanosensors prepared with nanomaterials provide solutions to these challenges. Nanomaterials such as gold nanoparticles, graphene and quantum dots are often preferred for the surface preparation of plasmonic nanosensors for the selective, sensitive and label-free detection of very low concentrations of pollutants in water.Methods:There are different plasmonic nanosensors such as electrochemical, colorimetry and optical sensors prepared using different nanomaterials for the determination of environmental pollutants. These different detection nanosensors also have many advantages and disadvantages. In this review, the use of different nanomaterials in different types of plasmonic nanosensors for the determination of environmental pollutants, their modification and their effects on performance in terms of signal enhancement will also be discussed.Results::When the studies in the literature are examined, although many articles have been published on the detection of pollutants in water, the number of publications specific to nanomaterial-based plasmonic nanosensors for detection is quite limited. In this review, we focused on the use of different nanomaterials in the preparation of nanosensor surfaces for the detection of environmental pollutants, and the preparation, optimization, experimental analysis and application areas of different plasmonic nanosensors made in the literature for detection methodsConclusion::Recent developments in plasmonic nanosensors, nanomaterials such as gold nanoparticles, graphene and quantum dots provide ultra-sensitive detection at the molecular level, leading to extraordinary developments. Nanomaterials have important plasmonic properties and are preferred for the selective, sensitive and label-free detection of very low water pollutant concentrations. In studies conducted in the literature, it has been observed that environmental pollutants such as toxin, bacteria, heavy metal ions, pesticides, especially in water, are determined and analyzed. In these review, it was observed that the sensitive and selective properties of nanomaterial-based nanosensors yielded results with low detection limits. The current review includes developments and application-oriented progress of nanomaterial-based plasmonic nanosensors, especially for the detection and quantification of various pollutants and environmental pollutants in water.