bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in Prostate Cancer Transcriptomes by Age at Diagnosis: Are Primary Tumors from Older Men Inherently Different?
Authors: Zhou Charlie D. , Pettersson Andreas , Plym Anna , Tyekucheva Svitlana , Penney Kathryn L. , Sesso Howard D. , Kantoff Philip W. , Mucci Lorelei A. , Stopsack Konrad H. 
Published: September 2022

Abstract

Older age at diagnosis is consistently associated with worse clinical outcomes in prostate cancer. We sought to characterize gene expression profiles of prostate tumor tissue by age at diagnosis. We conducted a discovery analysis in The Cancer Genome Atlas prostate cancer dataset (n = 320; 29% of men &gt;65 years at diagnosis), using linear regressions of age at diagnosis and mRNA expression and adjusting for TMPRSS2:ERG fusion status and race. This analysis identified 13 age-related candidate genes at FDR &lt; 0.1, six of which were also found in an analysis additionally adjusted for Gleason score. We then validated the 13 age-related genes in a transcriptome study nested in the Health Professionals Follow-up Study and Physicians’ Health Study (n = 374; 53% of men &gt;65 years). Gene expression differences by age in the 13 candidate genes were directionally consistent, and age at diagnosis was weakly associated with the 13-gene score. However, the age-related genes were not consistently associated with risk of metastases and prostate cancer–specific death. Collectively, these findings argue against tumor genomic differences as a main explanation for age-related differences in prostate cancer prognosis.

Prevention Relevance:
Older age at diagnosis is consistently associated with worse clinical outcomes in prostate cancer. This study with independent discovery and validation sets and long-term follow-up suggests that prevention of lethal prostate cancer should focus on implementing appropriate screening, staging, and treatment among older men without expecting fundamentally different tumor biology.
BÍBLIA HEBRAICA: A ESTÉTICA COMO PONTE DOS DIÁLOGOS ENTRE O SAGRADO E O HUMANO
Authors: Almeida Davi Tichiriã Fèlix de 
Published: September 2022

RESUMOO objetivo deste trabalho é apresentar a Bíblia Hebraica sob o viés estético, focando-se nela como fenômeno artístico-literário criativo, inovador e, sobretudo renovador (CHWARTS), posto que ao ressignificar-se constantemente, seus contextos, fazem com que, dentro de seus limites como obra, ela se expanda e se flexibilize artisticamente, através do papel engajado de seus leitores como intérpretes e re-escritores (ADORNO e HORKHEIMER), sob a égide da “regra de fé e de prática”, contemporaneizando-a.Palavras-chave: Bíblia Hebraica, Hermenêutica, Estética, Literatura Hebraica
JUDAÍSMO REFORMISTA NO BRASIL: SOB O OLHAR DE CONVERTIDOS PELA SINAGOGA DA ARI DO RIO DE JANEIRO
Authors: Castro Michelle Gonçalves 
Published: September 2022

Pautando-me pelos dados colhidos em formulários enviados a um grupo de convertidos ao judaísmo (2006-2016) pela sinagoga da Associação Religiosa Israelita do Rio de Janeiro, pretendo apresentar as perspectivas daqueles que responderam ao formulário mencionado sobre o que é o Judaísmo Reformista brasileiro, assim como as características peculiares dessa corrente judaica dentro da sociedade brasileira, em comparação com o Reformismo em outros países da América Latina, além de EUA e Canadá, logicamente de acordo com a vivência de cada entrevistado.Palavras-chave: Judaísmo reformista, Modernidade, Identidade Judaica
Mulheres e o Holocausto. Narrativas de Sobreviventes Judias.
Authors: Souza Lilian Ferreira 
Published: September 2022

A partir do registro das narrativas orais sobre o Holocausto pretendemos analisar testemunhos que expressem as trajetórias das mulheres sobreviventes do nazismo. Como critério optamos pelas narrativas daquelas que passaram por campos de concentração e/ou de trabalho forçados, por guetos e/ou atuaram em frentes de resistência como partisans. O foco está nas histórias de vida daquelas que escolheram o Brasil como comunidade de destino pressionada pela política antissemita endossada pelo Terceiro Reich e países colaboracionistas que previam a “Solução Final” para o povo judeu. Assim os registros dos testemunhos têm como objetivo documentar estas narrativas redimensionadas à luz de documentos pessoais. Para nós - intermediários e interlocutores - esse exercício de reflexão ajudará a (re)pensar a sociedade que, ainda hoje, convive com novos genocídios.
Presença do Sublime na Consolação às Tribulações de Israel, de Samuel Usque
Authors: Schuartz Miriam Sílvia 
Published: September 2022

Este artigo busca introduzir o leitor no universo da obra Consolação às tribulações de Israel, de Samuel Usque, texto fundamental da literatura judaica em língua portuguesa e da Literatura Portuguesa do século XVI. Esta leitura está ancorada nos aspectos retóricos e poéticos que caracterizam o estilo sublime do texto usquiano.
A Mensagem do Profeta Isaías Referente à Campanha de Senaqueribe Contra Judá
Authors: Jesus Carolina Alvino Fortes de 
Published: September 2022

Este artigo analisa os capítulos 36 e 37 do livro de Isaías, trecho referente ao ataque do rei assírio Senaqueribe contra o Reino de Judá durante o reinado de Ezequias, em 701 A.E.C. Para isso, pretende-se esboçar o contexto histórico a partir do estudo das fontes extrabíblicas de natureza epigráfica – o relato da campanha de Senaqueribe contra Judá nos anais reais assírios –, iconográfica – o painel encontrado no palácio de Senaqueribe em Nínive, cujos entalhes narram o cerco e a conquista da cidade de Lachish, do reino de Judá, durante sua campanha militar – e arqueológica – as escavações na cidade de Lachish. Além disso, para ampliar o entendimento sobre a passagem de Isaías, conta-se com o auxílio das fontes bíblicas, encontradas, principalmente, no livro de Isaías e na narrativa sobre o acontecimento em II Reis.
O Estudo da Diferença de Ideologias Entre Gerações a Partir do Conto Yad Vashem
Authors: Wakrat Anath Czeresnia 
Published: September 2022

O conto “Yad Vashem”, do escritor israelense Aharon Megued, publicado em 1955, narra a história do avô Ziskind, originário da Ucrânia, que residia em Israel. Quando Ziskind soube que sua neta Raia estava grávida, pediu que ela desse para o filho que ia nascer o nome de Mêndele, caso fosse homem. A partir daí começa a discussão sobre a escolha de um nome típico da tradição europeia, defendido pelo avô ou um nome israelense, próprio de uma ideologia sionista, exigido pela neta. O conflito revela uma crise de identidade profunda entre o imigrante e seus descendentes que se resume no choque entre o antigo e o novo, num conflito geracional capaz de colocar em jogo o passado e o futuro de um povo.
David Reubeni e o Messianismo Judaico Português na Primeira Metade do Século XVI
Authors: Justiniano Silva Saulo Henrique 
Published: September 2022

O presente trabalho busca compreender o fenômeno messiânico judaico português na primeira metade do século XVI, bem como o desenvolvimento deste a partir da aparição de David Reubeni em Portugal, este que se apresentara como embaixador de um reino judeu na Arábia, fez com que muitos cristãos-novos acreditassem nele como sendo o Messias consolador, dando origem a uma onda de fervor messiânico no reino que será contido após a instauração do Tribunal do Santo Ofício. Palavras-chaves: Messianismo Judaico. Cristãos-Novos portugueses. David Reubeni.
O Aspecto Metafórico das Ampliações Lexicais Sofridas por Algumas Palavras da Língua Hebraica
Authors: Cruz Anna Cecília de Paula 
Published: September 2022

Este trabalho tem por objetivo apresentar, de forma concisa, as linhas gerais do projeto que venho desenvolvendo em nível de mestrado, Alguns aspectos metafóricos nas ampliações lexicais por ampliação semântica na língua hebraica. Minha proposta é demonstrar, por meio da perspectiva da semântica cognitiva, que algumas das ampliações lexicais sofridas no hebraico, por ampliação semântica, têm como base um processo cognitivo metafórico. De acordo com Lakoff e Johnson em “Metaphors we live by” (1980), nós pensamos e compreendemos o mundo por meio de metáforas. Assim, tentaremos demonstrar a tese destes autores, usando como exemplo as palavras hebraicas mekhdal (omissão, negligência), khassut (refúgio, patrocínio) e hitlahavut (inflamação, entusiasmo).
“Como Caíram os Valentes”: Uma Introdução ao Gênero Qinah
Authors: Moreira Jayme Alves 
Published: September 2022

A partir das passagens de 2 Samuel 1:17-27 e 3:32-34, este artigo propõe uma investigação do gênero qînāh[1] (“elegia”) no interior da Bíblia Hebraica, identificando os principais traços dele e comparando-o a gêneros próximos. O objetivo é compreender a função social desse gênero nos tempos bíblicos de forma a descobrir possíveis razões para a sua reduzida presença na Bíblia Hebraica. Finalmente, vai se constatar de que modo essas passagens tornam evidentes certos traços do personagem Davi, ao qual são atribuídos os textos, o que enriquecerá o entendimento dos relatos, contidos no livro de Samuel, que contam a sua ascensão ao trono e o seu reinado. [1] Todas as transliterações do hebraico foram retiradas do site < www.biblos.com >. Acesso em: 15/12/2011 às 17h.
Role of Inferior Vena Cava Dynamics for Estimating Right Atrial Pressure in Congenital Heart Disease
Authors: Egbe Alexander C. , Connolly Heidi M. , Pellikka Patricia A. , Anderson Jason H. , Miranda William R. 
Published: September 2022

Background:
Inferior vena cava (IVC) size and collapsibility (IVC dynamics) are used for estimating right atrial pressure (RAP). However, the diagnostic performance of the American Society of Echocardiography IVC criteria for estimating RAP in patients with congenital heart disease are unknown. The purpose of this study was to assess the role of IVC dynamics for estimating RAP in adults with congenital heart disease.

Methods:

We conducted a retrospective study of adults with congenital heart disease that underwent cardiac catheterization and echocardiogram at Mayo Clinic (2003–2019). IVC diameter was measured at inspiration (IVC
min
) and end-expiration (IVC
max
), and IVC collapsibility index (IVC
CI
) was calculated.

Results:

Based on 918 patients, we observed a good correlation between IVC
max
and invasive RAP (
r
=0.56,
P
<0.001); IVC
min
and RAP (
r
=0.58,
P
<0.001); and IVC
CI
(
r
=−0.72,
P
<0.001). There was excellent correlation between invasive RAP and estimated RAP using IVC
CI
(
r
=0.80,
P
<0.001). We observed that IVC
CI
<60% had superior diagnostic performance as compared with American Society of Echocardiography criteria (IVC
max
>2.1 cm, area under the curve difference 0.15,
P
<0.001; IVC
CI
<50%, area under the curve difference 0.09,
P
=0.008; combination of IVC
max
>2.1 cm; and IVC
CI
<50%, area under the curve difference 0.06,
P
=0.02). Estimated RAP >10 mm Hg based on IVC
CI
had comparable prognostic performance as invasive RAP but superior prognostic performance as the American Society of Echocardiography criteria.

Conclusions:

IVC
CI
<60% was the best criterion to identify patients with elevated RAP. IVC
CI
was comparable to invasively measured RAP in its relation to prognosis. Further studies are required to determine whether the use of IVC
CI
in clinical decision-making will improve clinical outcomes in this population.
Prevalence and Impact of Neoatherosclerosis on Clinical Outcomes After Percutaneous Treatment of Second-Generation Drug-Eluting Stent Restenosis
Authors: Chen Zhaoyang , Matsumura Mitsuaki , Mintz Gary S. , Noguchi Masahiko , Fujimura Tatsuhiro , Usui Eisuke , Seike Fumiyasu , Hu Xun , Jin Ge , Li Chenguang , Salem Hanan , Fall Khady N. , Shlofmitz Evan , Kirtane Ajay J. , Cao J. Jane , Moses Jeffrey W. , Ali Ziad A. , Jeremias Allen , Shlofmitz Richard A. , Maehara Akiko 
Published: September 2022

Background:
Clinical and morphological factors associated with lipidic versus calcified neoatherosclerosis within second-generation drug-eluting stents and the impact of lipidic versus calcified neoatherosclerosis on long-term outcomes after repeat intervention have not been well studied.

Methods:
A total of 512 patients undergoing optical coherence tomography before percutaneous coronary intervention for second-generation drug-eluting stents in-stent restenosis were included. Neoatherosclerosis was defined as lipidic or calcified neointimal hyperplasia in ≥3 consecutive frames or ruptured lipidic neointimal hyperplasia. The primary outcome was target lesion failure (cardiac death, target vessel myocardial infarction, definite stent thrombosis, or clinically driven target lesion revascularization).

Results:
The overall prevalence of neoatherosclerosis was 28.5% (146/512): 56.8% lipidic, 30.8% calcified, and 12.3% both lipidic and calcific. The prevalence increased as a function of time from stent implantation: 20% at 1 to 3 years, 30% at 3 to 7 years, and 75% >7 years. Renal insufficiency, poor lipid profile, and time from stent implantation were associated with lipidic neoatherosclerosis, whereas severe renal insufficiency, female sex, and time from stent implantation were associated with calcified neoatherosclerosis. Multivariable Cox regression revealed that female sex and lipidic neoatherosclerosis were associated with more target lesion failure, whereas stent age and final minimum lumen diameter after reintervention were related to lower target lesion failure. Calcified neoatherosclerosis was not related to adverse events after reintervention for in-stent restenosis given a large enough minimum lumen diameter was achieved.

Conclusions:
Lipidic but not calcified neoatherosclerosis was associated with poor subsequent outcomes after repeat revascularization if optimal stent expansion was achieved in lesions with calcified neoatherosclerosis.
Convictions and Penalties among Rescue and Non-rescue Nonhuman-Animal Hoarders
Authors: Willetts Marion C. 
Published: September 2022

Abstract
The overarching purpose of this pilot study was to compare the likelihood of conviction and the imposition of penalties in nonhuman-animal hoarding cases among those affiliated with established animal rescues and those not affiliated. A secondary purpose was to examine what additional characteristics of hoarders and hoarding cases are associated with conviction and penalties. Manifest content coding was conducted on the media reports and court dockets of a convenience sample of 84 animal hoarding cases. The affiliated did not significantly differ from the nonaffiliated with regard to the likelihood of conviction or the imposition of legal penalties upon conviction. A prior history of hoarding and the number of animals involved in a case influenced case outcomes in limited and inconsistent respects; however, a preponderance of nonsignificant findings suggests that much judicial discretion operates in the prosecution of animal hoarding cases.
Summit Diplomacy as Theatre of Sovereignty Contestation
Authors: Ku Minseon 
Published: September 2022

Summary
The recent revival in the interest in summitry in International Relations scholarship conceptualises it as an elite-centred or foreign policy-focused process targeting foreign governments and publics. This article makes a theoretical intervention on the effects of summitry by foregrounding publics as audiences of international politics who can exercise agency. Because summits are primarily elite-staged performances of Westphalian principles of state sovereignty, they generate a political space for audiences to publicly embrace or contest summitry performances and their meanings of sovereignty. They can do so by co-performing with or by counter-performing elitist summitry performances, which can generate narratives with potential to shape and alter domestic societies in the long run.
Werner Beierwaltes and the Yearning for Transcendence
Authors: Hedley Douglas 
Published: September 2022

Abstract
In this paper we explore some of the key themes in the thought of Werner Beierwaltes. He established a reputation as a scholar of Neoplatonism during a period of great renewal of Neoplatonic studies in the last century, and that esteem was justly deserved. Yet his work was motivated by the faith in Platonism as a living tradition and a resolute conviction that metaphysics is an ineluctable part of the philosophical vocation; and indeed he was irritated by jejune or simplistic critiques of metaphysics. Plotinus was at the centre of his scholarship, which explored the great themes of Neoplatonism through medieval, Renaissance and Idealistic philosophy into the contemporary context. Theology, aesthetics and the question of selfhood or subjectivity were recurrent topics in his writing. The discussion of these problems was fueled by a keen sense of the abiding significance of the Platonic tradition for the most puzzling and urgent intellectual questions.
Going Nuclear, but How? The Netherlands Army and Tactical Nuclear Warfare in Europe, 1953–1968
Authors: Sanders Daan , Hoffenaar Jan 
Published: September 2022

Abstract
In the historiography of nuclear arms in the Cold War the political and military strategic levels are dominant; little attention has been paid to the sub-strategic levels. This is understandable, because most archival material has been destroyed or is still classified. However, it is also remarkable because tactical nuclear weapons (tnw) were a crucial element in nato strategies and because all nato forces had to prepare, down to the lowest levels, to fight a war by nuclear means. Based on previously unused archives, this article analyses how the Dutch army, as an army of a small nato-member state, adapted step by step to the nuclearisation of land warfare in the period 1953 to 1968. Which role were the tnw s assigned in the war plans? But also, how realistic would these plans have been, given the influence of (inter)national political developments, moral and psychological aspects, and military-technical and military-tactical issues?
Engagement in and Interaction with Parliamentary Ecosystems
Authors: Fitsilis Fotis , Todd Bruce Philip 
Published: September 2022

Abstract
This is a report on the 15th Workshop of Parliamentary Scholars and Parliamentarians that took place over the weekend of 30–31 July 2022 in Wroxton, Oxfordshire, in the United Kingdom. Scores of scholars, practitioners, and Members of Parliament (mp s) from around the world gathered once again at the event’s remarkable venue, the Wroxton Abbey, for a two-day practical exchange on issues around parliamentary development and reforms. This time, the Workshop focussed on the state-of-play of and new concepts for strengthening public engagement in the democratic process. Moreover, the greater event constitutes a forum of international professional exchange between parliamentary practitioners and scholars and the sharing of best-practice, with the overall goal of promoting positive change and improvements to the efficiency, transparency, representation and therefore legitimacy of parliaments. The report captures the highlights, lessons-learned, and expectations from a memorable event that set the stage for further research and policy activities.
E-cigarette addiction and harm perception: Does initiation flavor choice matter?
Authors: Hung Man , Spencer Andrew , Hon Eric S. , Licari Frank W. , Cheever Val Joseph , Moffat Ryan , Goh Clarissa , Raymond Ben , Lipsky Martin S. 
Published: September 2022

Abstract
Introduction
The 21st century was marked by a dramatic increase in adolescent e-cigarette use in the United States (US). The popularity of non-traditional flavor types, including fruit and pastry, is thought to contribute toward growing product use nationally, leading to a variety of federal and state regulations limiting the use of non-traditional flavors in the US. The relationship between flavor type and increased adolescent use suggests a possible link between flavor use and addiction and harm perception. This study assessed if the flavor type used when initiating e-cigarette use predicted addiction and harm perceptions.

Methods
The study utilized data from the multi-wave youth Population Assessment of Tobacco Health Study. It explored the impact initiating e-cigarette use with traditional versus non-traditional flavor types among cigarette users on the outcome variables: e-cigarette addiction and harm perception. Both e-cigarette addiction and harm perception were measured using self-report, Likert scale questionnaires. Descriptive statistics characterized the study variables and linear regression analyses performed to test whether flavor initiation type is associated with addiction and harm perception.

Results
The study sample consisted of 1,043 youth (weighted N = 1,873,617) aged 12 to 17 years who reported at least one instance of e-cigarette use. After adjusting for age, age of onset, sex, race and annual household income there was no statistically significant difference in addiction levels between those initiating with traditional versus non-traditional flavors (p = 0.294). Similarly, traditional versus non-traditional flavor initiation did not show a statistically significant difference in adolescent e-cigarette harm perceptions (p = 0.601).

Conclusions
Traditionally flavored e-cigarette initiation produces similar risk for addiction and harm perceptions as non-traditionally flavored initiation. These findings suggest that banning non-traditional flavors alone may be ineffective in curbing e-cigarette addiction and harm perception. Additional research is needed to better understand which e-cigarette product characteristics and behaviors may be associated with greater addiction and reduced harm perceptions.