bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel method for low-cost and rapid preparation of nanoporous phenolic aerogels and its performance regulation mechanism
Authors: Zhang Yijun , Yuan Chengfan , Ding Jie , Zhuang Yingluo , Li Yan , Wang Cunku , Huang Zhixiong 
Published: November 2022

Abstract
The large-scale application of phenolic aerogel is limited by its complex and lengthy production process as well as its expensive cost. Herein a simultaneous drying-curing method for phenolic aerogels was designed based on the sol–gel process, and a series of phenolic aerogels with different hexamethylenetetramine (HMTA) contents were prepared. The material parameters such as microstructure, pore structure, mechanical properties, shrinkage, and density of the aerogel were characterized. The results show that compared with the conventional full-sealing method, the simultaneous drying-curing method shortens the preparation time of aerogels by nearly half and improves the safety of the preparation process. The prepared phenolic aerogels still maintain the nanoporous microscopic morphology. When the HMTA content is 1/6 of the phenolic mass, the linear shrinkage rates of the aerogels prepared by this method and the conventional full-sealing method are 9.8 and 9.4%, respectively. The densities are 0.25 and 0.22 g·cm−3, and the BET specific surface areas are 54.42 and 54.31 m2·g−1, and the compressive yield strengths are 1.76 and 1.16 MPa. At the same time, the thermal conductivity of the phenolic aerogels prepared by the simultaneous drying-curing method is less than 0.06 W·(m·K)–1 at room temperature. These results indicate that the properties of the aerogels prepared by the simultaneous drying-curing method are close to those prepared by the conventional method, which proves that this method has guiding significance for the large-scale, low-cost, and rapid production of nanoporous phenolic aerogels.
Aplikasi Insecta Crochet pada Knee Length Dress
Authors: Hidayah Arina , Marlina Marlina 
Published: November 2022

Karya tulis ini mengangkat bagaimana mengaplikasikan teknik crochet bentuk serangga pada knee length dress. Pengaplikasian bentuk serangga digunakan untuk menunjukkan bahwa Indonesia dengan kekayaan fauna terutama serangga masih menjadi perhatian sehingga masih relevan diaplikasikan pada busana yang masih diminati oleh banyak wanita. Tujuan penulisan untuk menggali kreativitas terhadap produk busana dengan menyatukan crochet dan busana dress dengan aplikasi crochet bertema insect. Metode yang digunakan dalam karya tulis ini adalah Problem based Learning (PBL) atau Pembelajaran Berbasis Masalah (PBM) adalah metode pengajaran yang bercirikan adanya permasalahan nyata sebagai konteks untuk belajar berfikir kritis dan keterampilan memecahkan masalah, dan memperoleh pengetahuan. Karya tulis ini menghasilkan proses kreatif pembuatan busana wanita berupa knee length dress dengan pengaplikasian insect crochet pada busana tersebut.
Lithuanian dabar̃ ‘now’ and the Baltic *-ā́-illative
Authors: Ostrowski Norbert 
Published: November 2022

Lithuanian dabar̃ ‘now’ comes from the illative of the continuative adverb dãbar ‘still, yet’; schematically: dãbar ‘still, yet’ → illative *dabar-ā́ > *dabarà > dabar̃ ‘now’. Change in accentuation visible in dãbar ‘still, yet’ vs. dabar̃ ‘now’ brings to mind a similar process in illative forms, e.g. acc.sg. *mìškan → ill.sg. *miškan-ā́ > dial. miškanà > ill.sg. miškañ. The primary illative *dabar- ā́ is preserved in the dialectal dabarõs ‘now’, which is traced back to a contraction of *dabar-à-es. The postposition *-es is a mark of the enclitic verb esti ‘is’. The shift of accent like between dãbar ‘still, yet’ and dial. dabarõs ‘now’ can also be observed in a few other adverbs, e.g. *pa gãli (cf. OLith. ik’ gâli ‘to the end’) → pagaliõs ‘in the end’.
From gaspaža to kundze: female honorifics in Latvian in the 16th–19th centuries
Authors: Vanags Pēteris 
Published: November 2022

This article focuses on those modern and historical Latvian words that, in addition to the main component of the meaning ‘adult woman’, also include the components of respect and/or social status, namely, gaspaža, madama, dāma, and kundze. The article discusses the emergence and change of use of these lexemes in the 16th–19th century with a special focus on the processes of the middle and second half of the 19th century.
In less than a century, the semantic field of the honorific female designations in the Latvian language has undergone significant changes. From one word gaspaža to four in the 1870s, but the most significant changes took place in the last twenty years of the century. In formal and neutral use, kundze and dāma were strengthened, each occupying a different part of the semantic field, competing synonymously only in the general sense of ‘honorable woman’, as well as in the function of address. However, even in this case, kundze is more often used in the context of the singular and dāma in the plural. In turn, lexemes gaspaža and madama have become characteristic of colloquial language and fiction; they often have an ironic or negative connotation.
Double chambered right ventricle with ruptured sinus of Valsalva: rare entity
Authors: Lalwani Jaya , Kumar Lokesh , . Rameshwar , M. Jagadeesan 
Published: November 2022

Valsalva sinus aneurysm (SVAs) and double-chambered right ventricle (DCRV) is an uncommon congenital heart defect and are usually associated with ventricular septal defect (VSD) in 50% to 60% of patient’s population. The current case report had documented a 59 years old hypertensive asymptomatic male with a known case of SVAs presented to our hospital following device closure for 6 months. On examination, the patient was diagnosed to have DCRV induced by SVAs prior to the closure along with other factors. However, to the best of our knowledge, this is the first case report on DCRV induced by SVAs in synergy with other associated multifactors and without VSD among the Indian population.
The patterns of head and neck tumours in Northern Ghana: a histopathological review in a tertiary referral hospital in Northern Ghana
Authors: Der Edmund M. , Antwi Kwadwo F. , Adjeso Theophilus J. K. 
Published: November 2022

<p class="abstract"><strong>Background:</strong> There is paucity of published data on head and neck tumours (HNTs) in Ghana, even the few studies available were conducted in the middle and southern belts of the country. The present study in northern Ghana, was conducted to study the histopathological characteristics of HNTs and offer recommendations.</p><p class="abstract"><strong>Methods:</strong> This retrospective study analysed HNTs for the past 10 years at the Tamale Teaching Hospital in northern Ghana. </p><p class="abstract"><strong>Results:</strong> There were 576 HNTs, with 66.0% benign and 34.0% malignant. The mean age (years) was 34.9±21.6. Females were commonly affected 53.6%. Benign tumours were diagnosed in relatively young patients with mean age of 29.6±19.2, compared to 44.9±22.6 for the malignant tumours. Patients commonly present late with HNTs. The common anatomical sites were: odontogenic and maxillofacial bone (18.4%), oral cavity and mobile tongue (18.1%), and hypopharynx and larynx (13.9%). The histopathological subtypes were: squamous papilloma (13.9%), squamous cell carcinoma (SCC) (12.8%), and salivary gland pleomorphic adenoma (9.4%). The common benign tumours were; squamous papilloma (21.1%), salivary glands pleomorphic adenoma (14.2%), and benign vascular tumours (13.9%). For malignant tumours the order was; SCC (37.8%), lymphoma (11.2%) and olfactory neuroblastoma (10.2%). A significant number of patients had no history of cigarette smoking (p&lt;0.0001).</p><p class="abstract"><strong>Conclusions:</strong> Benign tumours were the common neoplastic lesions within the head and neck region. HNTs were common in relatively young patients and in females. Benign tumours were diagnosed in relatively young patients compared to malignant tumours. Patient with malignant tumours presented early to health facilities, compared to those with benign tumours.</p>
Triple intervention in congenital wry neck: case report
Authors: Munjal Manish , Munjal Shubham , Arora Vineeta , Gill Karambir , Sharma Salony , Chawla Deeksha , Kaur Hardeep , Sandhu Loveleen , Sidhu Kanwarpreet , Pillai Anjana , Joshi Tanisha 
Published: November 2022

<p class="abstract">Wry neck or congenital muscular torticollis is consequent to shortened or contracted sternocleidomastoid muscle (SCM). A painless, retracted sternocleidomastoid muscle is the characteristic feature which results in tugging the neck towards affected side, and draws the shoulder upward and forces the chin in the opposite direction. The incidence is between 0.4 to 1.9%. A 17 years old lady with torticollis since childhood is being discussed in detail with the steps of surgical intervention; at three sites to attain a sternocleidomastoid release and resistance free neck and thus a free head movement. This was followed by application of cervical collar, active physiotherapy and postural exercises. The ignorance and improper advice during childhood had led to this marked deformity at adolescence.</p><p class="abstract"> </p>
Past Conditional Subjectivities: Enacting Relationships with the Non-Human in the Work of Ana Mendieta
Authors: Tedford Matthew Harrison 
Published: November 2022

Inspired by what literary scholar Lisa Lowe calls “the past conditional temporality”—or the “what could have been”—this paper examines how the work of 20th-century Cuban American performance artist Ana Mendieta challenges modernist ontologies that separate the human from the non-human, simultaneously calling on older ways of being and demonstrating that they never disappeared. Many argue that the ecological crises of the Anthropocene are in large part due to the proliferation of modernist worldviews that set humans apart from the non-human world. The rise of European rationalist philosophies in the early modern period played a central role in the proliferation of instrumentalist relationships between humans and the non-human world.
This paper explores how Mendieta’s Silueta and Rupestrian Sculptures series (from the 1970s and 1980s) resist the logic of European capitalism and colonialism, revealing that the relationships that rationalism sought to subdue have always existed, will continue to exist, and can proliferate. Symbolic communication is a key means of mediating and actualizing relationships between subjects, and so, if a non-instrumental relationship is possible between the human and non-human, visual art ought to be a possible means of enactment. Through Mendieta’s work, this paper considers the mechanisms by which this is possible. By considering meaning-making as a basis for life, the co-constitution of human/non-human subjectivities, and the inherent permeability of the category of the individual, this paper highlights counter-modernist visual art practices that are of special urgency in the age of the Anthropocene.
Study of urban sprawl using the built-up area extraction map and supervised classification Case Study Wilaya of Tizi-Ouzou, Algeria *
Authors: arab nabil amine 
Published: November 2022

Abstract
The objective of our study is to evaluate the phenomenon of urbanization in the wilaya of Tizi-Ouzou through two distinct methods, the first method is to generate a map of extraction of built-up areas (BAEMOLI) from the calculation of the index of normalized difference of the built-up NDBI OLI, the index of vegetation NDVI OLI and the modified index of normalized difference of the water MNDWI OLI, and the second method is to use the supervised classification has different period 1987, 2000, 2009, 2019 and 2021, we start with the first method in order to have a visual overview of the urban growth in the different regions of the wilaya of Tizi-Ouzou, and in knowledge of the limitations of the first method which certainly allows to have an approximate and global overview of the phenomenon to study something which is primordial to have a methodical approach of the phenomenon which rages in the wilaya and these regions, but which unfortunately does not make it possible to make the distinction between the bare grounds and the urban zones, thing which pushed us has used a second complementary method, that of the supervised classification in order to add a more detailed study by quantifying this urbanization, with figures and statistics which make it possible to analyze the phenomenon of urbanization with much more precision, and end up with explanations and interpretations drawn from past studies made on the six regions of the wilaya of Tizi-Ouzou
BMI across adulthood, COVID-19 and long COVID in two British birth cohorts
Authors: Staatz Charis Bridger , Bann David , Ploubidis George , Goodman Alissa , Silverwood Richard 
Published: November 2022

Abstract
Longer exposure to obesity, and thus a longer period in an inflamed state, may increase susceptibility to infectious diseases and worsen severity. Previous cross-sectional work finds higher BMI is related to worse COVID-19 outcomes, but less is known about associations with BMI across adulthood. To examine this, we used body mass index (BMI) collected through adulthood in the 1958 National Child Development Study (NCDS) and the 1970 British Cohort Study (BCS70). Participants were grouped by the age they were first overweight (> 25kg/m2) and obese (> 30kg/m2). Logistic regression was used to assess associations with COVID-19 (self-reported and serology-confirmed), severity (hospital admission and contact with health services) and long-COVID reported at ages 62 (NCDS) and 50 (BCS70). Longer exposure to obesity was associated with increased odds of adverse COVID-19 outcomes, but results were mixed and often underpowered. Those with early exposure to obesity were over twice as likely in NCDS (odds ratio (OR) 2.15, 95% confidence interval (CI): 1.17 to 4.00) and three times as likely in BCS70 (OR 3.01, 95% CI: 1.74 to 5.22) to have long COVID. In NCDS they were also over four times as likely to be admitted to hospital (OR 4.69, 95% CI: 1.64 to 13.39). Most associations were somewhat explained by contemporaneous BMI or reported health, diabetes or hypertension; however, the association with hospital admission in NCDS remained. An earlier age of obesity onset is related to COVID-19 outcomes in later life, providing evidence on the long-term impact of raised BMI on infectious disease outcomes in midlife.
Zyxin promotes hepatocellular carcinoma progression via activation the AKT/mTOR signaling pathway
Authors: Cai Tianying , Bai Junjie , Tan Peng , Huang Zhiwei , Liu Chen , Wu Ziming , Cheng Yonglang , Li Tongxi , Chen Yifan , Ruan Jian , Gao Lin , Du Yichao , Fu Wenguang 
Published: November 2022

Abstract
To investigate the regulatory effect and specific mechanism of the actin-interacting protein zyxin (ZYX) in hepatocellular carcinoma (HCC). HCC is one of the most common malignant tumors in the world which occurrence and development areregulated by multiple genes. We found that the expression of ZYX in HCC tissues was significantly higher than that in normal liver tissues. The results of cell proliferation assay, scratch test and transwell assay showed that high expression of ZYX promoted the proliferation, migration and invasion of hepatoma cell lines (PLC/PRF/5, HCCLM3), inhibiting the expression of ZYX reduced the proliferation, migration, and invasion of hepatoma cells(SK HEP-1, Huh-7). Further analysis found that the expression of cell cycle-related proteins, cell migration and invasion-related proteins were changed when the expression of ZYX changed. Xenograft models showed similar results. The AKT/mTOR signaling pathway is a classic pathway ofcancer development. We found that the phosphorylation level of AKT/mTOR protein was up-regulated with increasing ZYX expression and down-regulated with decreasing ZYX expression. While the addition of the AKT inhibitor MK2206 counteracted the proliferation, migration and invasion of HCC cells with increasing ZYX expression, the AKT activator SC79 also restored the proliferation, migration and invasion of HCC cells with decreasing ZYX expression. Therefore, we speculate that the expression of ZYX may promoting the progression of HCC by activating AKT/mTOR signaling pathway, thereby. This is also the first time to find the mechanism of ZYX in HCC, indicating that ZYX is a possible new target for HCC treatment.
A Case Report: Pulmonary Embolism (PE) in Hemodialysis Patients with Autogenous Arteriovenous Fistula (AVF) Occlusion during Ultrasonography
Authors: Zhu Xiaohua , Zhu Hong , Ding Zhihui , Yao Chunlei , Qian Houlong 
Published: November 2022

Abstract
Backgrounds: Symptomatic pulmonary embolism is rare and fatal. We report a case of a patient with fatal pulmonary embolism during ultrasonography examination of autogenous arteriovenous fistula.
Case presentation: We present the case of a 53-year-old woman with end-stage renal disease (ESRD). The left forearm arteriovenous fistula is the vascular access. After had maintenance hemodialysis for about 9 years, the patient developed an aneurysm behind the anastomosis. She visited the doctor after finding that the arteriovenous fistula tremor disappeared. During the ultrasound examination, the patient lost consciousness. Pulmonary embolism was confirmed by enhanced CT. The patient was improved after tracheal intubation and active anticoagulation therapy. The follow-up angiography showed arteriovenous fistula anastomotic stenosis, autologous arteriovenous reconstruction surgery was performed.
Conclusions: Symptomatic and fatal pulmonary embolism was rarely during ultrasonography examination of autogenous arteriovenous fistula. Therefore, clinicians should pay attention to this possibility to provide timely and appropriate treatment.
Identification of Myelodysplastic Syndrome Risk-related Genes and their Association with Immune Infiltration
Authors: Wang Wenqian , Fu Rong , Cui Daizheng , Yao Deyang , Wu Zhihua , Xie Wei , Li Chengyu , She Xinyi , Xin Hanchang , Song Xiaohang , Zeng Tiansheng , Ye Xu 
Published: November 2022

Abstract
Objective
Myelodysplastic syndrome (MDS) is a hematological malignancy. Recently, immune cells participate in the occurrence and progression of various tumors has revealed by many researches. In this study, we investigated the correlation between the expression levels of MDS risk-related genes and the ratio of tumor-infiltrating immune cells in CD34+ cells. Our research may provide some help for the basis of the pathogenesis of MDS and the prognosis analysis of patients.
Methods
This research was based on two microarray datasets GSE19429 and GSE58831. The differential expressed genes (DEGs) of low risk vs. high risk MDS were analyzed by GEO2R. The GO and KEGG pathways of DEGs were identified by enrichment analysis. Three risk-related genes were screened and identified by LASSO analysis and MCC algorithm. Then, the tumor immune cell infiltration of CD34+ cells in MDS patients were analyzed by CIBERSORT to define the differences in tumor immune cell infiltration between low-risk and high-risk MDS.
Results
We collected 179 transcriptomes and 159 transcriptomes from dataset GSE58831and GSE19429. We found that low-risk and high-risk MDS patients had significant differences in prognosis. Besides, 105 common DEGs was identified in both datasets, which were mainly enriched in malaria, African trypanosomiasis, transcriptional dysregulation in cancer, phagosome, and primary immunodeficiency in the KEGG pathway. Three risk-related genes were screened by LASSO analysis and MCC algorithm: CDC6, RRM2, HMMR. There was a significant difference in the prognosis between the high-risk group and the low-risk group differentiated by these 3 gene markers. In addition, Treg, mast cells, CD8+ T cells, Macrophage M2, Eosinophils and Neutrophils were also found significantly difference between low-risk and high-risk MDS in tumor immune cell infiltration (P < 0.05). Also, three risk-related genes and tumor immune cells were significantly correlated.
Conclusion
We screened out three risk-related genes in MDS. CDC6, HMMR and RRM2 are highly expressed in the low-risk group of MDS and low in the high-risk group, and the expression levels of the three genes are closely related to the infiltration of various immune cells. This conclusion has potential clinical prognostic value for MDS patients.
Transcription analysis of the THBS2 gene through regulation by potential non-coding diagnostic biomarkers and oncogenes of gastric cancer in the ECM receptor interaction signaling pathway: integrated systems biology and experimental investigation
Authors: Barani Ali , Beikverdi Kamyar , Mashhadi Benyamin , Parsapour Naeimeh , Rezaei Mohammad , Javid Pegah , Azadeh Mansoureh 
Published: November 2022

Abstract
Background
Gastric cancer (GC) is the second most frequent cause of cancer-related death worldwide and the fourth most common malignancy. Despite significant improvements in patient survival over the past few decades, the prognosis for patients with GC remains dismal because of the high recurrence rate. In this comprehensive systems biology and experimental investigation, we aimed to find new novel diagnostic biomarkers of GC through a regulatory RNA interaction network.
Methods
Gene expression, co-expression, and survival analyses were performed using microarray and RNAseq datasets (analyzed by R Studio, GEPIA2, and ENCORI). RNA interaction analysis was performed using miRWalk and ENCORI online databases. Gene set enrichment analysis (GSEA) was performed to find related signaling pathways of up and down-regulated genes in the microarray dataset. Gene ontology and pathway enrichment analysis were performed by the enrichr database. Protein interaction analysis was performed by STRING online database. Validation of expression and co-expression analyses was performed using a qRT-PCR experiment.
Results
Based on bioinformatics analyses, THBS2 (FC: 7.14, FDR < 0.0001) has a significantly high expression in GC samples. lncRNAs BAIAP2-AS1, TSIX, and LINC01215 have RNA interaction with THBS2. BAIAP2-AS1 (FC: 1.44, FDR: 0.018), TSIX (FC: 1.34, FDR: 0.038), and LINC01215 (FC: 1.19, FDR: 0.046) have significant up-regulation in GC samples. THBS2 has a significant role in the regulation of the ECM-receptor signaling pathway. miR-4677-5p has a significant RNA interaction with THBS2. The expression level of THBS2, BAIAP2-AS1, TSIX, and LINC01215 has a non-significant negative correlation with the survival rate of GC patients (HR: 0.28, logrank p: 0.28). qRT-PCR experiment validates mentioned bioinformatics expression analyses. BAIAP2-AS1 (AUC: 0.7136, p-value: 0.0096), TSIX (AUC: 0.7456, p-value: 0.0029), and LINC01215 (AUC: 0.7872, p-value: 0.0005) could be acceptable diagnostic biomarkers of GC.
Conclusion
BAIAP2-AS1, lncRNA LINC01215, lncRNA TSIX and miR-4677-5p might modulate the ECM-receptor signaling pathway via regulation of THBS2 expression level, as the high-expressed non-coding RNAs in GC. Furthermore, mentioned lncRNAs could be considered potential diagnostic biomarkers of GC.