bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic NLR and PLR in predicting Covid-19 severity: a retrospective cohort study
Authors: Asperges Erika , Albi Giuseppe , Zuccaro Valentina , Sambo Margherita , Pieri Teresa Chiara , Calia Matteo , Colaneri Marta , Maiocchi Laura , Melazzini Federica , Lasagna Angioletta , Peri Andrea , Mojoli Francesco , Sacchi Paolo , Bruno Raffaele 
Published: April 2022

Abstract
Background: the hyperinflammation phase of severe SARS-CoV-2 is characterized by complete blood count alterations. In this context, the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) can be used as prognostic factors. We study NLR and PLR trends at different timepoints and compute optimal cutoffs to predict four outcomes: use of Continuous Positive Airways Pressure (CPAP), ICU admission, invasive ventilation and death. Methods: we retrospectively included all adult patients with SARS-CoV-2 pneumonia admitted from 23rd January 2020 to 18th May 2021. Data were extracted using ICD9 codes and our Covid-19 registry. Analyses included descriptive statistics and non parametric tests to study the ability of NLR and PLR to distinguish the patients’ outcomes at each timepoint. ROC curves were built for NLR and PLR at each timepoint (minus discharge) in order to identify cutoffs to distinguish severe and non severe disease and their statistical significance was assessed with the Chi-square test. NLR and PLR were compared with DeLong’s test. Results: we included 2169 patients. NLR and PLR were higher in severe Covid-19 at all the timepoints, with a difference that gets bigger and a trend that is steeper in more severe disease. Both ratios were able to distinguish the outcomes at each timepoint. For NLR, the areas under the curve (AUROC) ranged between 0.59 and 0.81, for PLR, between 0.53 and 0.67. From each ROC curve we computed an optimal cutoff value (e.g. NLR 7 for CPAP for males at admission). NLR performed better than PLR. Conclusion: our results are in line with other studies that computed NLR and PLR trends and values in disease, especially with those that distinguished between different grades of severity. Our study is retrospective and single centre, and is limited by selection bias, but includes more than 2000 patients, thus limiting the confounding factors and outliers. Our cutoffs do not only deal with severity and mortality but allow for a more tailored approach. Future prospect include validating our cutoffs in a prospective cohort and comparing their performance against other Covid19 scores.
Symptoms of Anxiety but not Depression Before Start of Taxane-Based Chemotherapy are Associated with Peripheral Neuropathy: a Multicenter Study in Women with Breast Cancer
Authors: Hinnen Chris , Verhoeff-Jahja R. , Kuile M.M. ter , Weijl N.I. , Oosterkamp H.M. , Cloos M. , Portielje J.E.A. , Kroep J.R. 
Published: April 2022

Abstract
Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy, especially after taxane based therapy. This study aimed to examine the relationship between symptoms of anxiety and depression before start of taxane-based chemotherapy and the development of CIPN in women with breast cancer.Methods In this prospective study, women with breast cancer receiving taxane-based (neo)adjuvant chemotherapy were recruited from four hospitals in the Netherlands. Patients completed questionnaires assessing anxiety and depressive symptoms before treatment and CIPN before treatment (T0), 6 weeks after start of treatment (T1), after the last cycle of chemotherapy (T2) and 6 months after end of treatment (T3). Mixed model analyses were used to investigate whether medium/high levels of anxiety or depression at baseline are associated with the level of CIPN during and after treatment. Results Among the 61 participating women, 14 (23%) reported medium/high levels of anxiety and 29 (47.5%) reported medium/high levels of depressive symptoms at baseline. The group of women with medium/high baseline levels of anxiety showed a significantly higher increase in CIPN during and after chemotherapy than women with low baseline levels of anxiety (p < .001). No relationship between depressive symptoms at baseline and the development of CIPN was found.Conclusion This study showed that baseline medium to high levels of anxiety, but not depressive symptoms impacted the development of CIPN during and in the 6 months after treatment.
RIS-Assisted Multi-User MIMO-DQSM Transmission System
Authors: Castillo-Soria Francisco R. , Azurdia-Meza Cesar A. , Kumaravelu Vinoth Babu , Simón Jorge , Gutierrez Carlos , Del-Puerto-Flores J. A. 
Published: April 2022

Abstract
This paper presents a reconfigurable intelligent surface (RIS) assisted multiuser (MU) multiple-input multiple-output (MIMO) system. Instead of being applied at the remote RIS, the phase shift vector is applied at the base station (BS) by using an additional precoding stage. The overall system performance is improved by incorporating a double quadrature spatial modulation (DQSM) transmission technique. Results show that the proposed system has gains of up to 17 dB in bit error rate (BER) and a reduction in detection complexity of 51% when compared with the conventional MU-MIMO system based on spatial multiplexing (SMux). Compared with a similar system based on amplify and forward (AF) relay-assisted technique, the proposed system has up to 18 dB gain in BER performance under the same conditions and parameters. Mainly, the proposed system significantly reduces the signal processing required at the RIS.
A Landslide Susceptibility Mapping Using CIBD-CURE Algorithm and LEPAM Methods for Baota District, China
Authors: Mwakapesa Deborah S. , Xiaoji Lan , Mensah I. K. , Nanehkaran Y. A. , Xiangtai Wang , Li Ye , Liang Chen , Wei Liu , Mao Yimin 
Published: April 2022

Abstract
Landslide susceptibility mapping (LSM) is one of the crucial steps in managing and mitigating landslides. This study targets at developing a new LSM model for Baota District in China, using a new clustering method namely CIBD-CURE, which combines the city block distance (CIBD) and traditional clustering using representatives (CURE) algorithm. It aims at addressing limitations of inability to identify clusters (subclasses) with arbitrary shapes and varying sizes, sensitivity to noise, inability to perform well in large study areas with large dataset and inability to process rainfall (uncertain) data, which affect the results of traditional clustering algorithms in LSM. The CIBD was introduced into the CURE algorithm for processing uncertain data, then CIBD-CURE partitioned the mapping units into arbitrary shaped and sized subclasses with respect to their underlying geology and topography characteristics, and handled noise successfully. Furthermore, LEPAM method was proposed to sort the subclasses into five landslide susceptibility levels. Finally, standard statistical measures were applied to evaluate the model’s performance and compared it against CURE, AHC-OLID, HC and KPSO clustering models, along with DTU and NBU classification models. The result analysis showed data the proposed model attained higher performance. This LSM study will be useful for landslides management strategies not only for this study area but also other affected areas around the world.
Pulmonary and Renal Long COVID at Two-year Revisit
Authors: Guo Tiannan , Wang Jing , Liang Xiao , Zheng Yufen , Zhu Yi , Zhou Kai , Wu Xiaomai , Sun Rui , Hu Yifan , Zhu Xiaoli , Chi Hongbo , Chen Shanjun , Lyu Mengge , Xie Yuting , Yi Xiao , Liu Wei , Cai Xue , Li Sainan , Zhang Qiushi , Wu Chunlong , Shi Yingqiu , Wang Donglian , Peng Minfei , Zhang Ying , Liu Huafen , Zhang Chao , Quan Sheng , Kong Ziqing , Kang Zhouyang , Zhu Guangjun , Zhu Hongguo , Chen Shiyong , Liang Junbo , Yang Hai , Pang Jianxin , Fang Yicheng , Chen Haixiao , Li Jun , Xu Jiaqin , Shen Bo 
Published: April 2022

Abstract
More than 450 million individuals have recovered from COVID-19, but little is known about the host responses to long COVID. We performed proteomic and metabolomic analyses of 991 blood and urine specimens from 144 COVID-19 patients with comprehensive clinical data and up to 763 days of follow up. Our data showed that the lungs and kidneys are the most vulnerable organs in long COVID patients. Pulmonary and renal long COVID of one-year revisit can be predicted by a machine learning model based on clinical and multi-omics data collected during the first month from the disease onset with an ACC of 87.5%. Serum protein SFTPB and ATR were associated with pulmonary long COVID and might be potential therapeutic targets. Notably, our data show that all the patients with persistent pulmonary ground glass opacity or patchy opacity lesions developed into pulmonary fibrosis at two-year revisit. Together, this study depicts the longitudinal clinical and molecular landscape of COVID-19 with up to two-year follow-up and presents a method to predict pulmonary and renal long COVID.
Long-term effectiveness of XEN 45 gel-stent in open-angle glaucoma patients
Authors: Marcos-Parra María Teresa , Salinas-López Javier Alejandro , Mateos-Marcos Carlos , Moreno-Castro Lucia , Moreira Angi Lizbeth Mendoza , Santonja Juan José Pérez 
Published: April 2022

Abstract
Purpose: To assess the effectiveness of XEN45, either alone or in combination with phacoemulsification, in open-angle glaucoma (OAG) patients in a real-world scenario. Additionally, we evaluated the effect of the surgeon's experience on clinical outcomes. Methods: Retrospective and single center study conducted on OAG patients who underwent XEN45-implant, either alone or in combination with cataract surgery. We compared the clinical outcomes of the first-30 XEN devices implanted from June-2016 (First-cohort) versus the first-30 XEN devices implanted from January-2018 (second-cohort). The primary endpoint was the mean change in intraocular pressure (IOP) from baseline to the last follow-up visit. Results: One Hundred-and-fifty-four eyes, 37 (24.0%) eyes who underwent XEN-alone and 117 (76.0%) eyes who underwent XEN+Phacoemulsification were included. The mean preoperative IOP was significantly lowered from 19.1±5.0 mmHg to 14.9±3.8 mmHg at month-36, p<0.0001. Preoperative IOP was significantly lowered from 19.2±5.3 mmHg and 18.9±4.7 mmHg to 15.2±4.0 mm Hg and 14.1±3.1 mmHg at month-24 in the first- and second-cohorts, respectively; p<0.0001 each, with no significant differences between them. In the overall study population, the mean number of antiglaucoma medications was significantly reduced from 2.1±0.8 to 0.2±0.6, p<0.0001. The proportion of eyes with a final IOP ≤14 mmHg and ≤16 mmHg, without treatment, was significantly greater in the second cohort (p=0.0471 and 0.0047, respectively). Thirty-six (23.4%) eyes required a needling procedure. Conclusions: XEN implant, significantly lowered IOP and reduced the need of ocular hypotensive medication, while maintaining a good safety profile. Additionally, XEN45 was associated with a short learning curve.
Infrared small target detection based on multi-directional cumulative measure
Authors: Zhang Guofeng , Ma Hongbing , Hamdulla Askar , Ubul kurban 
Published: April 2022

Abstract
Robustness of small target detection is a researchable hotspot in infrared surveillance system. The residual phenomenon of background clutter is universal in current local comparison methods. Algorithm of sparse low-rank decomposition restoration cannot be applied to the actual situations due to the long time consumption.This letter proposes a multi-directional cumulative measure(MDCM) to enhance saliency and effectiveness of weak-small target detection. Firstly, multi-directional cumulative mean difference is implemented in central layer and background layer to estimate the background, while the multi-directional cumulative derivative multiplying is calculated in central-active layer to characterize overall target’ heterogeneity, then technology of image fusion is adopted to eliminate interference of false target. Finally, a simple adjudicative technology is employed toward separated target region from complex scenes. Compared to up to date existing approaches,extensive simulational testing on four public datasets prove that proposed approach is capable of separating small targets efficiently from an irregular background in a single-scale window and achieve a comparable or even better accuracy.
Pro-survival factor EDEM3 confers therapy resistance in prostate cancer
Authors: Scott Emma , Garnham Rebecca , Cheung Kathleen , Duxfield Adam , Elliott David , Munkley Jennifer 
Published: April 2022

Abstract
Prostate cancer is the most common cancer in men, and it is primarily driven by androgen steroid hormones. The glycosylation enzyme EDEM3 is controlled by androgen signalling and important for prostate cancer viability. EDEM3 is a mannosidase that trims mannose from mis-folded glycoproteins, tagging them for degradation through endoplasmic reticulum associated degradation. Here, we find that EDEM3 is upregulated in prostate cancer, and this is linked to poorer disease-free survival. Depletion of EDEM3 from prostate cancer cells induces an ER stress transcriptomic signature, and EDEM3 overexpression is cyto-protective against ER stressors. EDEM3 expression also positively correlates with genes involved in the unfolded protein response in prostate cancer patients and its expression can be induced through exposure to radiation. Importantly, the overexpression of EDEM3 promotes radio-resistance in prostate cancer cells and radio-resistance can be reduced through depletion of EDEM3. Our data thus implicate increased levels of EDEM3 with a role in prostate cancer pathology and reveal a new therapeutic opportunity to sensitise prostate tumours to radiotherapy.
Making Better Keratoplasty Decisions for Acanthamoeba Keratitis: A Meta-analysis
Authors: Wang Leying , Wei Zhenyu , Cao Kai , Xu Xizhan , Zhang Zijun , Chen Qiankun , Liang Qingfeng 
Published: April 2022

Abstract
Acanthamoeba keratitis (AK) is a blinding disease with increasing incidence. Keratoplasty is the common therapy method for AK; however, the suitable times and types of keratoplasty for AK remains unclear. These systemic review intended to assess the outcomes of AK undergoing different keratoplasty procedures. Literature searches were conducted in Pubmed, EMBASE, Web of Science, and the Cochrane. Eleven studies with 216 eyes were included. The meta-analysis showed optical keratoplasty had better best corrected visual acuity (BCVA), higher graft survival rate, lower recurrence and multiple keratoplasties rate than therapeutic keratoplasty. The occurrence rate of postoperative complications were similar between optical keratoplasty and therapeutic keratoplasty. The AK patients performed therapeutic keratoplasty within 5 months of AK onset had significant better final BCVA than those who after 5 months of AK duration. Moreover, therapeutic deep anterior lamellar keratoplasty (TDALK) reserved better BCVA than therapeutic penetrating keratoplasty (TPK). The eyes performed TPK were prone to need multiple keratoplasties than those with TDALK. These results suggested optical keratoplasty was superior to therapeutic keratoplasty in AK patients. The drug-resistant AK patients should be underwent therapeutic keratoplasty promptly, especially within 5 months of AK onset. TDALK was a preferable therapeutic keratoplasty option for AK patients where possible.
Bernoulli wavelet least square support vector regression: Robust numerical method for systems of fractional differential equations
Authors: Rahimkhani Parisa , Ordokhani Yadollah , Sabermahani Sedigheh 
Published: April 2022

Abstract
In this study, a new hybrid method is developed to solve a system of linear or nonlinear fractional differential equations using Bernoulli wavelets (Bws) and the least square support vector regression(LS-SVR). For this purpose, we present Bw operator of Riemann-Liouville fractional integration for Bw and use it in our scheme. In the proposed technique, we approximate the unknown functions via Bws, then with the help of Bw operator of fractional integration and LS-SVR, we reduce the problem to an algebraic system. In this way, we simplify the computation of the considered system. The error analysis is proposed. Finally, we demonstrate the applicability of the present scheme by solving several numerical examples.
Richness contributes higher on soil microbial community resistance while nutrient contributes higher on resilience to a thermal stress
Authors: Zhou Hanchang , Ma Anzhou , Chang Ruiying , Liu Guohua , Zhuang Guoqiang 
Published: April 2022

Abstract
Soil microbial communities play irreplaceable roles in regulating environment. However, global climate change induced extreme weather events were reported capable reshape microbial community composition, which exert possible influences on the environment regulation function. Unfortunately, the compositional response of microbial community to extreme weather events and the potential factors regulating this response were still scarcely explored up to date. To fill the gap, here we sampled soils from 5 different type ecosystems and conducted a simulated extreme high-temperature stress experiment. The results showed that the complex ecosystems (like forests) had higher richness reduction than simple ecosystems (like bare land) during stress stage, most bacterial community richness kept decreasing while most fungal community richness were relatively unchanged during recovery stage. Despite the fungal communities in different types of ecosystems showed different and specific changes in the face of stress during the stress and recovery stage, the relative abundances of α-Proteobacteria were enhanced by stress in simple ecosystems but decreased in complex ecosystems, and the recovery stage of simple ecosystems were characterized by the trade-off between α-, β- and γ-Proteobacteria while complex ecosystems were by Firmicutes. Further analysis showed that the simple ecosystems tend to possess higher resistance and lower resilience while the complex ecosystems displayed the opposite trend. Resistance and resilience were significantly negatively correlated. Structural equation modeling showed that richness provided a higher contribution to bacterial and fungal resistance than to resilience while nutrients provided a higher contribution to resilience than to resistance. This research explored the influence of extreme high temperature stress on soil microbial community and the resistance and resilience of microbial community different types ecosystems to the stress, highlighted the respectively greater relative contribution of richness and nutrients offered to resistance and resilience, which provided valuable information for future prediction on microbial community response to climatic stresses.
L.reuteri JMR-01 adjuvant 12C6+ irradiation exert anti-colon carcinoma effects by modulating the gut microbiota in mice
Authors: Bai Jin , Wang Shuyang , Xu Fuqiang , Dong Miaoyin , Wang Junkai , Sun Xisi , Xiao Guoqing 
Published: April 2022

Abstract
Probiotics such as Lactobacillus can modulate the intestinal microbiota and have been considered as an effective strategy for ameliorating colon carcinoma; nevertheless, its efficiency remains the biggest challenge. We investigated the efficacy of JMR-01 adjuvant 12C6+ irradiation on the treatment of mice bearing CT-26 and clarified the underlying mechanisms including modulating immune cells and intestinal flora. Anti-proliferation effect of live probiotic JMR-01 and inactived probiotic (LP + IP) on CT-26 reached a maximum of 39.55% among other experiment groups at 24 h when the ratio of cell to CFU was 1:1 in vitro, which was at a high level to our knowledge. These activities have been fully validated in vivo, mice treated by 12C6+ irradiation + LP + IP (IR + LP + IP) for fifty-day held the highest survival rate (71.4%) and the cure rate (14.3%), which were higher than that in the reported literatures. Additionally, we found that the strongest stimulation index of splenocyte (2.47) and the phagocytosis index peritoneal macrophage (3.68) were achieved by LP + IP compared with single LP and IP. We demonstrated a significantly decreased abundance of Bacteroides fragilis, Clostridium perfringens and the increased abundance of Lactobacillus and Bifidobacterium in mice administrated of LP + IP via plate counting of microbial in fecal. Moreover, fecal enzyme activities were dramatically decreasing and short chain fatty acids (SCFA) concentrations were significantly increasing in IR + LP + IP group compared with tumor control group, which was consistent with the trend of plate counting results. JMR-01 LP + IP adjuvant 12C6+ irradiation could mitigate cancer progression by modulating immune cells and intestinal flora.
Distribution of transient receptor potential vanilloid types 2 and 1 in the distal colon in a trinitrobenzene sulfonicacid-induced rat colitis model with visceral hypersensitivity
Authors: Matsumoto Kenjiro , Sugimoto Fumika , Mizuno Toshiki , Hayashi Taisei , Okamura Ririka , Nishioka Takuya , Yasuda Hiroyuki , Horie Syunji , Kido Mizuho A. , Kato Shinichi 
Published: April 2022

Abstract
Transient receptor potential vanilloid type 2 (TRPV2) and type 1 (TRPV1) are originally identified as heat-sensitive TRP channels. We compared the expression patterns of TRPV2 and TRPV1 in the rat distal colon and extrinsic primary afferent neurons, and investigated their roles in visceral hypersensitivity in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis rats. Both TRPV2 and TRPV1 expressions in the colon, dorsal root ganglion (DRG), and nodose ganglion (NG) were significantly upregulated in the TNBS-induced colitis model. TRPV2 cell bodies co-localized with the intrinsic primary afferent marker NeuN and the inhibitory motor neuronal marker nNOS in the myenteric plexus. TRPV2 expressions were further detected in the resident macrophage marker ED2 in the mucosa. In contrast, no TRPV1-expressing cell bodies were detected in the myenteric plexus. Both TRPV2- and TRPV1-positive cell bodies in the DRG and NG were double-labeled with the neuronal retrograde tracer fluorescent fluorogold. Large- and medium-sized TRPV2-positive neurons were labeled with the A-fiber marker NF200, calcitonin gene-related peptide (CGRP), and substance P (SP) in the DRG while small-sized TRPV1-positive neurons were labeled with the C-fiber markers IB4, CGRP, and substance P. TRPV2-and TRPV1-positive NG neurons were labeled with NF200 and IB4. Although TNBS treatment did not affect the TRPV1 and TRPV2 subpopulations in the DRG and NG, increased p-ERK1/2-positiveneurons, which co-localized with TRPV1, and TRPV2. Both TRPV2 and TRPV1 antagonists significantly alleviated visceral hypersensitivity in TNBS-induced colitis model rats. These findings suggest that sensitization and upregulation of intrinsic/extrinsic TRPV2- and extrinsic TRPV1-neurons may contribute to visceral hypersensitivity.