bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of inactivation of aldehyde dehydrogenase on pheromone production by a gut bacterium of an invasive bark beetle, Dendroctonus valens
Authors: Cao Qingjie , Koski Tuuli‐Marjaana , Li Huiping , Zhang Chi , Sun Jianghua 
Published: August 2022

AbstractSemiochemical‐based management strategies are important for controlling bark beetles, such as invasive Red Turpentine Beetle (Denroctonus valens), the causal agent for mass mortality of pine trees (Pinus spp.) in China. It has been previously shown that the pheromone verbenone regulates the attack density of this beetle in a dose‐dependent manner and that the gut bacteria of D. valens are involved in verbenone production. However, molecular functional verification of the role of gut bacteria in the pheromone production of D. valens is still lacking. To better understand the molecular function of gut bacterial verbenone production, we chose a facultative anaerobic gut bacterium (Enterobacter xiangfangensis) of D. valens based on its strong ability to convert cis‐verbenol to verbenone, as shown in our previous study, and investigated its transcriptomics in the presence or absence of cis‐verbenol under anaerobic conditions (simulating the anoxic environment in the beetle's gut). Based on this transcriptome analysis, aldehyde dehydrogenase (ALDH1) was identified as a putative key gene responsible for verbenone production and was knocked‐down by homologous recombination to obtain a mutant E. xiangfangensis strain. Our results show that these mutants had significantly decreased the ability to convert the monoterpene precursor to verbenone compared with the wild‐type bacteria, indicating that ALDH1 is primarily responsible for verbenone conversion for this bacterium species. These findings provide further mechanistic evidence of bacterially mediated pheromone production by D. valens, add new perspective for functional studies of gut bacteria in general, and may aid the development of new gene silencing‐based pest management strategies.
The GPR88 agonist RTI‐13951‐33 reduces alcohol drinking and seeking in mice
Authors: Ben Hamida Sami , Carter Michelle , Darcq Emmanuel , Sourty Marion , Rahman Md Toufiqur , Decker Ann M. , Jin Chunyang , Kieffer Brigitte L. 
Published: August 2022

AbstractGPR88 is an orphan G‐protein‐coupled receptor that is considered a potential target to treat neuropsychiatric disorders, including addiction. Most knowledge about GPR88 function stems from knockout mouse studies, and in vivo pharmacology is still scarce. Here we examine the effects of the novel brain‐penetrant agonist RTI‐13951‐33 on several alcohol‐related behaviours in the mouse. In the intermittent‐access‐two‐bottle‐choice paradigm, the compound reduced excessive voluntary alcohol drinking, while water drinking was intact. This was observed for C57BL/6 mice, as well as for control but not Gpr88 knockout mice, demonstrating efficacy and specificity of the drug in vivo. In the drinking‐in‐the‐dark paradigm, RTI‐13951‐33 also reduced binge‐like drinking behaviour for control but not Gpr88 knockout mice, confirming the alcohol consumption‐reducing effect and in vivo specificity of the drug. When C57BL/6 mice were trained for alcohol self‐administration, RTI‐13951‐33 decreased the number of nose‐pokes over a 4‐h session and reduced the number of licks and bursts of licks, suggesting reduced motivation to obtain alcohol. Finally, RTI‐13951‐33 did not induce any place preference or aversion but reduced the expression of conditioned place preference to alcohol, indicative of a reduction of alcohol‐reward seeking. Altogether, data show that RTI‐13951‐33 limits alcohol intake under distinct conditions that require consummatory behaviour, operant response or association with contextual cues. RTI‐13951‐33 therefore is a promising lead compound to evaluate GPR88 as a therapeutic target for alcohol use disorders. More broadly, RTI‐13951‐33 represents a unique tool to better understand GPR88 function, disentangle receptor roles in development from those in the adult and perhaps address other neuropsychiatric disorders.
Impacts of recreational cannabis legalization on cannabis use: a longitudinal discordant twin study
Authors: Zellers Stephanie M. , Ross J. Megan , Saunders Gretchen R. B. , Ellingson Jarrod M. , Anderson Jacob E. , Corley Robin P. , Iacono William , Hewitt John K. , Hopfer Christian J. , McGue Matt K. , Vrieze Scott 
Published: August 2022

AbstractAimsTo estimate the effect of recreational legalization on cannabis use frequency and sources of variance across legal environments.DesignLongitudinal discordant twin and gene–environment interaction models in twins recruited from birth records and assessed prospectively.SettingThe United States, including states with different recreational cannabis policies before and after 2014, when recreational cannabis was first legalized.ParticipantsTwo longitudinal, prospectively assessed samples of American twins aged 24–47 (n = 1425 in legal states, n = 1996 in illegal states), including 111 monozygotic pairs discordant for residence.MeasurementsCurrent cannabis use frequency (measured continuously and ordinally) was the primary outcome, and the predictor was recreational status of cannabis (legal/illegal) in the participant’s state of residence at the time of assessment. Covariates include age, sex and cannabis use frequency prior to 2014.FindingsAccounting for pre‐2014 use, residents of legal states used cannabis more frequently than residents of illegal states (b = 0.21, P = 8.08 × 10−5). Comparing 111 pairs of monozygotic twins discordant for residence confirmed the effect (b = 0.18, P = 0.014). There was inconclusive evidence for genetic influences on cannabis use frequency that were specific to the legal environment [χ2 = 2.9 × 10−9, degrees of freedom (d.f.) = 1, P > 0.999]. Existing genetic influences were moderated by the legal environment, as the genetic correlation between marijuana use before and after legalization was lower in states that legalized (rgenetic = 0.24) compared with states that did not (rgenetic = 0.78, Pdifference = 0.016).ConclusionsIn the United States, there appears to be a ~ 20% average increase in cannabis use frequency attributable to recreational legalization, consistent across increasingly rigorous designs. In addition, the heritability of cannabis use frequency appears to be moderated by legalization.
Dermoscopic findings and histopathological correlation in large cell acanthoma
Authors: Jung Jang Hwan , Jeong Sun Mun , Kwon Do Ik , Seong Seol Hwa , Jang Ji Yun , Kim Joon Hee , Park Jong Bin , Suh Kee Suck , Jang Min Soo 
Published: August 2022

AbstractSince large cell acanthoma (LCA) has many overlapping clinical and histopathological features with other epidermal pigmented tumours, an additional method to differentiate it would be of great clinical significance. A retrospective study was performed on 33 lesions (26 patients) to identify distinct dermoscopic findings of LCA and to describe dermoscopic‐histopathological correlations. The results revealed that dermoscopy significantly aids in the distinction of LCA from other epidermal tumours included in the differential diagnosis. Yellow opaque homogeneous background, brown dots, and moth‐eaten border are common findings, and prominent skin markings and short white streaks are additional distinguishing features. Several important findings that are common in other diseases are rare in LCA.
Disturbing Disruptions and Aspirational Participation as an Academic Anthropologist: Reflections on COVID‐19, Neoliberalism, and Climate Change
Authors: Fazzino David 
Published: August 2022

SUMMARY
In this article, I outline my aspirational participation as an academic anthropologist in the three arenas wherein my worth, and hence expendability, is measured: teaching, scholarship, and service. I reflect on the personal, social, and ecological impacts of my anthropological fieldwork and development over the last two decades in light of the life‐altering effects of COVID‐19. While reflexive turns continue to guide the accountability of researchers to ourselves and our interlocutors in writing and research processes, further consideration of how and where we show up in our teaching and at professional meetings will help to address how neoliberalism has shaped our discipline, leading to a greater realization of anthropology’s transformative potential to address social justice and ecological concerns. I suggest that rather than lamenting the pause provided by COVID‐19 and longing for anthropology and academia as it was, or as we imagined it to be, this disruption might give us pause to draw from our reflexive tradition. The world has been remade, providing anthropologists with additional tools to address our elitism and ecological footprint, including the destruction wrought by our contribution to climate change on some of the same communities for whom we advocate.
Identifying data‐fields for a gastrointestinal cancer clinical quality and safety registry: a systematic literature review
Authors: Unasa Hanson , Hutchinson Alexandra , DeSouza Steve , Poole Lydia , Knudsen Caroline , Hill Andrew , MacCormick Andrew D. 
Published: August 2022

AbstractBackgroundDespite considerable advancements in Upper Gastrointestinal Cancer (UGIC) care in Australia and Aotearoa New Zealand (AAoNZ), the absolute number of deaths remains high. Clinical Quality and Safety Registries (CQRs) enable benchmarking and performance appraisal, however an AAoNZ CQR does not exist. To create this, we first aim to identify all national and international UGIC CQRs and amalgamate their data fields and definitions through a systematic review.MethodsA Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) compliant systematic review was performed using Scopus, Embase, Cochrane and MEDLINE databases. Human studies, in English, reporting on the development of and/or results of all CQRs focused on UGIC were included. Individual data fields were extracted and placed into four categories. Data fields could be further synthesized into data field subcategories if there were direct similarities among studies.ResultsA total of 32 studies—23 national audits or registries and nine international benchmarking studies—were included, encompassing 899 073 patients in 48 countries. Of the total of 1710 individual data fields, 1526 (89.2%) were reported with a definition. The most number of data fields related to Treatment Factors (41.2%), with least number pertaining to Outcomes (7.8%).ConclusionsThis systematic review has amalgamated all data fields and definitions from UGIC CQRs or studies. Establishing an AAoNZ Clinical and Quality Safety Registry for our population will enable us to benchmark the performance of our UGIC care internationally. Further studies are indicated in the context of the use of the Delphi method to facilitate this process.
A case‐study approach to mapping Corporate Citizenship
Authors: Homer Stephen T. 
Published: August 2022

AbstractThis explores what responsible business practice within the context of Malaysia, an Eastern collective society, diverging from the Western individualistic society where most Corporate Social Responsibility (CSR) research originates. A bottom‐up approach was adopted, incorporating different stakeholder perspectives of a case‐study firm, widely acknowledged for its CSR programs. Concept mapping method was selected because it is a structural conceptualization method designed to organize and represent ideas from an identified group adding structure to disorganized and subjective ideas. By using concept mapping all the various perspectives and ideas were brought together to create a single conceptualization. The findings from the concept mapping present 101 statements which produced seven clusters; Products & Services, Community Oriented, Stakeholder & Business Value, Employee Oriented, Legal & Ethical Responsibilities, Environmental & Social Oriented, and Philanthropic Oriented. These clusters covered the whole conceptual domain of Corporate Citizenship and demonstrated multiple CSR theories, including corporate sustainability, stakeholder concept, and shared value, were apparent, while also uncovering some unique aspects from the normative stakeholder perspective. The implications of this study suggest that while some aspects of globally institutionalized CSR are generically accepted, there are contextually specific aspects which need to be considered as these may contradict or conflict with the “global” standards.
A rapidly expanding cutaneous tumour in the context of a Janus kinase inhibitor agent following allogeneic stem cell transplant
Authors: Davies Anna , Salisbury Jon , Mehra Varun , Papa Sophie , Basu Tanya 
Published: August 2022

Abstract
Ruxolitinib is a selective, Janus kinase (JAK)1 and JAK2 inhibitor, which is effective in management of chronic graft-versus-host disease (cGvHD). However, the ensuing immunosuppressive effects can give rise to aggressive cutaneous tumours, including Merkel cell carcinoma. We present this case to highlight the development of cutaneous tumours with ruxolitinib, an increasingly used therapy, and the challenge of managing such tumours in the context of refractory cGvHD.
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Thick crusted plaques on the periorificial area in a young woman
Authors: Pathania Yashdeep Singh , Budania Anil , Mudugal Ravikumar , Sureka Binit , Khera Sudeep 
Published: August 2022

Abstract
We report a young woman with periorificial erosions and thick crusts mimicking pemphigus foliaceous, who was found to have an underlying pancreatic malignancy with normal blood glucose and glycosylated haemoglobin levels.
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Severe atopic dermatitis and concurrent severe hidradenitis suppurativa successfully treated with dupilumab
Authors: Cho Min Kyung , Shin Jung U , Kim Dong Hyun , Lee Hee Jung 
Published: August 2022

Abstract
We report a clinical experience of treating concomitant atopic dermatitis and hidradenitis suppurativa (HS) with dupilumab. This report is particularly noticeable in terms of disease severity and treatment duration compared to previous reported cases, suggesting long-term dupilumab therapy can contribute to disease control even in patients with severe HS.
Sustained and rebound effect of repeated low‐level red‐light therapy on myopia control: A 2‐year post‐trial follow‐up study
Authors: Xiong Ruilin , Zhu Zhuoting , Jiang Yu , Kong Xiangbin , Zhang Jian , Wang Wei , Kiburg Katerina , Yuan Yixiong , Chen Yanping , Zhang Shiran , Xuan Meng , Zeng Junwen , Morgan Ian G. , He Mingguang 
Published: August 2022

AbstractBackgroundTo evaluate the long‐term efficacy and safety of continued repeated low‐level red‐light (RLRL) therapy on myopia control over 2 years, and the potential rebound effect after treatment cessation.MethodsThe Chinese myopic children who originally completed the one‐year randomised controlled trial were enrolled. Children continued RLRL‐therapy were defined as RLRL‐RLRL group, while those who stopped and switched to single‐vision spectacle (SVS) in the second year were RLRL‐SVS group. Likewise, those who continued to merely wear SVS or received additional RLRL‐therapy were SVS‐SVS and SVS‐RLRL groups, respectively. RLRL‐therapy was provided by an at‐home desktop light device emitting red‐light of 650 nm and was administered for 3 min at a time, twice a day and 5 days per week. Changes in axial length (AL) and cycloplegic spherical equivalence refraction (SER) were measured.ResultsAmong the 199 children who were eligible, 138 (69.3%) children attended the examination and 114 (57.3%) were analysed (SVS‐SVS: n = 41; SVS‐RLRL: n = 10; RLRL‐SVS: n = 52; RLRL‐RLRL: n = 11). The baseline characteristics were balanced among four groups. In the second year, the mean changes in AL were 0.28 ± 0.14 mm, 0.05 ± 0.24 mm, 0.42 ± 0.20 mm and 0.12 ± 0.16 mm in SVS‐SVS, SVS‐RLRL, RLRL‐SVS and RLRL‐RLRL group, respectively (p < 0.001). The respective mean SER changes were −0.54 ± 0.39D, −0.09 ± 0.55D, −0.91 ± 0.48D, and −0.20 ± 0.56D (p < 0.001). Over the 2‐year period, axial elongation and SER progression were smallest in RLRL‐RLRL group (AL: 0.16 ± 0.37 mm; SER: −0.31 ± 0.79D), followed by SVS‐RLRL (AL: 0.44 ± 0.37 mm; SER: −0.96 ± 0.70D), RLRL‐SVS (AL: 0.50 ± 0.28 mm; SER: −1.07 ± 0.69D) and SVS‐SVS group (AL: 0.64 ± 0.29 mm; SER: −1.24 ± 0.63D). No self‐reported adverse events, functional or structural damages were noted.ConclusionsContinued RLRL therapy sustained promising efficacy and safety in slowing myopia progression over 2 years. A modest rebound effect was noted after treatment cessation.
Fire severity and post‐fire mulching effects on N transformation rates of temperate soils during the first critical winter–spring period
Authors: Fernández‐Fernández María , Rütting Tobias , González‐Prieto Serafin J. 
Published: August 2022

AbstractWildfires are increasing worldwide and, therefore, the extents of their on‐ and off‐site impacts are particularly important on soil erosion and nutrient cycles. To mitigate post‐fire erosion, mulching is increasingly being used, but its effects on the nitrogen (N) cycle are poorly known. To fill this gap of knowledge, gross N fluxes were modelled with Ntrace to compare with unburnt soils (US) the effects of intermediate (BI) and high severity (BH) burning, and post‐fire straw mulching (BIM and BHM). Two wildfires, two‐time points after the fire and 20 soil‐treatment combinations were studied. The mineralization of soil organic N to NH4+ (MSON) increased in BI (1.9–6.9×) with respect to US, with no clear trends observed in BH and mulched treatments. In most soils, NH4+ immobilisation in labile () and recalcitrant soil organic matter (SOM) () was more important than abiotic NH4+ fixation () and together were larger (3.5–11×) in BI than in US, while contrasting results were found depending on time after a fire (BH, BHM, BIM) and wildfire characteristics (BHM, BIM). Autotrophic nitrification () was included in the best model for all soils, whereas heterotrophic nitrification (OSON) was undetectable in most BH soils. Total nitrification ( + OSON) decreased with time after the fire in BH, increased in US and BI, and was differently affected by mulching depending on fire severity and time from the fire. While NO3− immobilisation () was frequently modelled only for BI soils, the dissimilatory NO3− reduction to NH4+ (DNRA) was retained in the best models for all soils and it was reduced by soil burning, whereas a short‐lived increase was induced by mulching. Denitrification (), modelled for most soils, was negatively affected by burning and positively by mulching. In summary, wildfires tended to increase MSON and , decrease DNRA and and had no clear influence on and nitrification. These effects are usually mitigated by mulching which, however, tended to enhance nitrification.Highlights
Direction and magnitude of changes in soil gross N fluxes depend on fire severity.
Usually, wildfires increased MSON and , and decreased DNRA and .
No clear post‐fire trend was found for and nitrification.
Fire effects on gross N fluxes are (partially) counterbalanced by mulching.
Hidden effects of habitat restoration on the persistence of pollination networks
Authors: Gaiarsa Marilia P. , Bascompte Jordi 
Published: August 2022

AbstractPast and recent studies have focused on the effects of global change drivers such as species invasions on species extinction. However, as we enter the United Nations Decade of Ecosystem Restoration the aim must switch to understanding how invasive‐species management affects the persistence of the remaining species in a community. Focusing on plant‐pollinator interactions, we test how species persistence is affected by restoration via the removal of invasive plant species. Restoration had a clear positive effect on plant persistence, whereas there was no difference between across treatments for pollinator persistence in the early season, but a clear effect in late season, with higher persistence in unrestored sites. Network structure affected only pollinator persistence, while centrality had a strong positive effect on both plants and pollinators. Our results suggest a hidden effect of invasive plants—although they may compete with native plant species, invasive plants may provide important resources for pollinators, at least in the short term.
Developmental plasticity in thermal tolerance: Ontogenetic variation, persistence, and future directions
Authors: Pottier Patrice , Burke Samantha , Zhang Rose Y. , Noble Daniel W. A. , Schwanz Lisa E. , Drobniak Szymon M. , Nakagawa Shinichi 
Published: August 2022

AbstractUnderstanding the factors affecting thermal tolerance is crucial for predicting the impact climate change will have on ectotherms. However, the role developmental plasticity plays in allowing populations to cope with thermal extremes is poorly understood. Here, we meta‐analyse how thermal tolerance is initially and persistently impacted by early (embryonic and juvenile) thermal environments by using data from 150 experimental studies on 138 ectothermic species. Thermal tolerance only increased by 0.13°C per 1°C change in developmental temperature and substantial variation in plasticity (~36%) was the result of shared evolutionary history and species ecology. Aquatic ectotherms were more than three times as plastic as terrestrial ectotherms. Notably, embryos expressed weaker but more heterogenous plasticity than older life stages, with numerous responses appearing as non‐adaptive. While developmental temperatures did not have persistent effects on thermal tolerance overall, persistent effects were vastly under‐studied, and their direction and magnitude varied with ontogeny. Embryonic stages may represent a critical window of vulnerability to changing environments and we urge researchers to consider early life stages when assessing the climate vulnerability of ectotherms. Overall, our synthesis suggests that developmental changes in thermal tolerance rarely reach levels of perfect compensation and may provide limited benefit in changing environments.
Potential rebound effects of teleworking on residential and daily mobility
Authors: Hostettler Macias Laura , Ravalet Emmanuel , Rérat Patrick 
Published: August 2022

AbstractThe practice of teleworking has been growing steadily in recent years with the development of ICT and the flexibilisation of work. The Covid‐19 pandemic and its stay‐at‐home restrictions have further accelerated this trend. As teleworking reduces the frequency of commuting, it also reduces CO2emissions and may be seen as a tool to regulate mobility. However, and especially since working from home enables more flexible working, teleworking may have various ‘rebound‘ effects on daily and residential mobility practices. Rebound effects include possible increases in the frequency or distance of journeys, such as an increase in non‐work‐related travel on teleworking days, as well as effects such as residential relocation or multilocal dwelling. In this article we intend to introduce and categorize the existing literature on the potential rebound effects of teleworking on residential and daily mobility. By critically assessing the literature we have identified the major lessons, while also noticing the limits of the research and a scarcity of qualitative approaches to understand how and why people who telework reinvest their non‐commuting time in other forms of mobility. Also missing in the literature is the longitudinal aspect, that is, the consideration of long‐term changes. These gaps have led us to formulate our proposition of a research agenda, where the lifestyle and life course approaches have emerged as crucial tools to understanding the motivations for teleworking and the respective rebound effects on residential and daily mobility.