bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards the construction of multi-centered black holes in AdS
Authors: Cai Yide , Liu James T. 
Published: October 2022

Abstract
We find a class of approximate perturbative solutions describing multi-centered BPS black holes in asymptotically AdS4. These black holes are moving coplanarly in a circular orbit with common radius but fixed phase differences, where the radius is characterized by a common boost velocity v. While the solutions are not complete, as they are only accurate up to $$ \mathcal{O} $$
O
(M2v2), we are able to locally investigate their supersymmetric properties in four-dimensional $$ \mathcal{N} $$
N
= 2 supergravity. The result indicates that, while a single BPS black hole preserves half of the supersymmetries, a configuration with two or more black holes is only 1/4 BPS. These perturbative solutions reduce in the asymptotically Minkowski limit to the multi-black hole solution of Majumdar and Papapetrou.
Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma
Authors: Navarro Natalia , Molist Carla , Sansa-Girona Júlia , Zarzosa Patricia , Gallo-Oller Gabriel , Pons Guillem , Magdaleno Ainara , Guillén Gabriela , Hladun Raquel , Garrido Marta , Segura Miguel F. , Hontecillas-Prieto Lourdes , de Álava Enrique , Ponsati Berta , Fernández-Carneado Jimena , Almazán-Moga Ana , Vallès-Miret Mariona , Farrera-Sinfreu Josep , de Toledo Josep Sánchez , Moreno Lucas , Gallego Soledad , Roma Josep 
Published: October 2022

AbstractThe majority of current cancer therapies are aimed at reducing tumour growth, but there is lack of viable pharmacological options to reduce the formation of metastasis. This is a paradox, since more than 90% of cancer deaths are attributable to metastatic progression. Integrin alpha9 (ITGA9) has been previously described as playing an essential role in metastasis; however, little is known about the mechanism that links this protein to this process, being one of the less studied integrins. We have now deciphered the importance of ITGA9 in metastasis and provide evidence demonstrating its essentiality for metastatic dissemination in rhabdomyosarcoma and neuroblastoma. However, the most translational advance of this study is to reveal, for the first time, the possibility of reducing metastasis by pharmacological inhibition of ITGA9 with a synthetic peptide simulating a key interaction domain of ADAM proteins, in experimental metastasis models, not only in childhood cancers but also in a breast cancer model.
The left–right side-specific endocrine signaling in the effects of brain lesions: questioning of the neurological dogma
Authors: Bakalkin Georgy 
Published: October 2022

AbstractEach cerebral hemisphere is functionally connected to the contralateral side of the body through the decussating neural tracts. The crossed neural pathways set a basis for contralateral effects of brain injury such hemiparesis and hemiplegia as it has been already noted by Hippocrates. Recent studies demonstrated that, in addition to neural mechanisms, the contralateral effects of brain lesions are mediated through the humoral pathway by neurohormones that produce either the left or right side-specific effects. The side-specific humoral signaling defines whether the left or right limbs are affected after a unilateral brain injury. The hormonal signals are released by the pituitary gland and may operate through their receptors that are lateralized in the spinal cord and involved in the side-specific control of symmetric neurocircuits innervating the left and right limbs. Identification of features and a proportion of neurological deficits transmitted by neurohormonal signals vs. those mediated by neural pathways is essential for better understanding of mechanisms of brain trauma and stroke and development of new therapies. In a biological context, the left–right side-specific neuroendocrine signaling may be fundamental for the control of the left- and right-sided processes in bilaterally symmetric animals.
The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations
Authors: Stalbow Lauren A. , Preuss Michael H. , Smit Roelof A. J. , Chami Nathalie , Bjørkhaug Lise , Aukrust Ingvild , Gloyn Anna L. , Loos Ruth J. F. 
Published: October 2022

Abstract
Aims/hypothesis
We examined the contribution of rare HNF1A variants to type 2 diabetes risk and age of diagnosis, and the extent to which their impact is affected by overall genetic susceptibility, across three ancestry groups.

Methods
Using exome sequencing data of 160,615 individuals of the UK Biobank and 18,797 individuals of the BioMe Biobank, we identified 746 carriers of rare functional HNF1A variants (minor allele frequency ≤1%), of which 507 carry variants in the functional domains. We calculated polygenic risk scores (PRSs) based on genome-wide association study summary statistics for type 2 diabetes, and examined the association of HNF1A variants and PRS with risk of type 2 diabetes and age of diagnosis. We also tested whether the PRS affects the association between HNF1A variants and type 2 diabetes risk by including an interaction term.

Results
Rare HNF1A variants that are predicted to impair protein function are associated with increased risk of type 2 diabetes in individuals of European ancestry (OR 1.46, p=0.049), particularly when the variants are located in the functional domains (OR 1.89, p=0.002). No association was observed for individuals of African ancestry (OR 1.10, p=0.60) or Hispanic-Latino ancestry (OR 1.00, p=1.00). Rare functional HNF1A variants were associated with an earlier age at diagnosis in the Hispanic-Latino population (β=−5.0 years, p=0.03), and this association was marginally more pronounced for variants in the functional domains (β=−5.59 years, p=0.03). No associations were observed for other ancestries (African ancestry β=−2.7 years, p=0.13; European ancestry β=−3.5 years, p=0.20). A higher PRS was associated with increased odds of type 2 diabetes in all ancestries (OR 1.61–2.11, p<10−5) and an earlier age at diagnosis in individuals of African ancestry (β=−1.4 years, p=3.7 × 10−6) and Hispanic-Latino ancestry (β=−2.4 years, p<2 × 10−16). Furthermore, a higher PRS exacerbated the effect of the functional HNF1A variants on type 2 diabetes in the European ancestry population (pinteraction=0.037).

Conclusions/interpretation
We show that rare functional HNF1A variants, in particular those located in the functional domains, increase the risk of type 2 diabetes, at least among individuals of European ancestry. Their effect is even more pronounced in individuals with a high polygenic susceptibility. Our analyses highlight the importance of the location of functional variants within a gene and an individual’s overall polygenic susceptibility, and emphasise the need for more genetic data in non-European populations.

Graphical abstract
Outcomes of Local Excision Compared to Radical Excision of Rectal Gastrointestinal Stromal Tumors: A Propensity‐Score Matched Analysis of the NCDB
Authors: Emile Sameh Hany , Horesh Nir , Freund Michael R. , Garoufalia Zoe , Gefen Rachel , Silva‐Alvarenga Emanuela , Wexner Steven D. 
Published: October 2022

AbstractBackgroundGastrointestinal stromal tumors (GISTs) account for <1% of gastrointestinal cancers. The present study aimed to assess the outcomes of local and radical excision of non‐metastatic rectal GISTs.MethodsThis study was a retrospective cohort analysis of patients with non‐metastatic rectal GISTs in the NCDB. Patients were divided according to the surgical approach into local and radical excision and were compared in regard to the baseline characteristics and outcomes. A propensity‐score matched analysis was performed to match the two groups for baseline confounders. The main outcomes were 5‐year overall survival (OS), surgical margins, hospital stay, short‐term mortality, and readmission.Results228 patients (54.8% male) with rectal GISTs were included. Before matching, 127 (55.7%) patients underwent local excision and 101 (44.3%) had radical excision. Patients who underwent local excision had more cT1‐T2 and low‐grade GISTs whereas patients who had radical excision received more neoadjuvant systemic treatment. After matching for clinical T stage, tumor grade, and neoadjuvant systemic therapy, 52 patients were included in each group. Local excision had a significantly higher rate of positive resection margins (42.2% vs. 19.1%, p = 0.02) and a shorter hospital stay (0 vs. 3 days, p < 0.001) than radical excision. The two groups had similar mean OS (139.8 vs. 133.1 months, p = 0.52).ConclusionsLocal excision was associated with a significantly higher incidence of positive resection margins and shorter hospital stay, yet similar overall survival to radical excision.
In situ high-temperature behaviour and breakdown conditions of uvite at room pressure
Authors: Ballirano Paolo , Celata Beatrice , Bosi Ferdinando 
Published: October 2022

AbstractThe thermal behaviour of an uvite from San Piero in Campo (Elba Island, Italy) was investigated at room pressure through in situ high-temperature powder X-ray diffraction (PXRD), until the breakdown conditions were reached. The variation of uvite structural parameters (unit-cell parameters and mean bond distances) was monitored together with site occupancies and we observed the thermally induced Fe oxidation process counterbalanced by (OH)−deprotonation, which starts at 450 °C and is completed at 650 °C. The uvite breakdown reaction occurs between 800 and 900 °C. The breakdown products were identified at room temperature by PXRD and the breakdown reaction can be described as follows: tourmaline → indialite + yuanfuliite + plagioclase + “boron-mullite” phase + hematite.
Contrast media timing optimization for coronary CT angiography: a retrospective validation study in swine
Authors: Hubbard Logan , Malkasian Shant , Zhao Yixiao , Abbona Pablo , Molloi Sabee 
Published: October 2022

Abstract
Objectives
The objective was to retrospectively develop a protocol in swine for optimal contrast media timing in coronary CT angiography (CCTA).

Methods
Several dynamic acquisitions were performed in 28 swine (55 ± 24 kg) with cardiac outputs between 1.5 and 5.5 L/min, for 80 total acquisitions. The contrast was injected (1mL/kg, 5mL/s, Isovue 370), followed by dynamic scanning of the entire aortic enhancement curve, from which the true peak time and aortic and coronary enhancements were recorded as the reference standard. Each dataset was then used to simulate two different CCTA protocols—a new optimal protocol and a standard clinical protocol. For the optimal protocol, the CCTA was acquired after bolus tracking-based trigging using a variable time delay of one-half the contrast injection time interval plus 1.5 s. For the standard protocol, the CCTA was acquired after bolus tracking-based triggering using a fixed time delay of 5 s. For both protocols, the CCTA time, aortic enhancement, coronary enhancement, and coronary contrast-to-noise ratio (CNR) were quantitatively compared to the reference standard measurements.

Results
For the optimal protocol, the angiogram was acquired within −0.15 ± 0.75 s of the true peak time, for a mean coronary CNR within 7% of the peak coronary CNR. Conversely, for the standard CCTA protocol, the angiogram was acquired within −1.82 ± 1.71 s of the true peak time, for a mean coronary CNR that was 23% lower than the peak coronary CNR.

Conclusions
The optimal CCTA protocol improves contrast media timing and coronary CNR by acquiring the angiogram at the true aortic root peak time.

Key Points
• This study in swine retrospectively developed the mathematical basis of an improved approach for optimal contrast media timing in CCTA.
• By combining dynamic bolus tracking with a simple contrast injection timing relation, CCTA can be acquired at the peak of the aortic root enhancement.
• CCTA acquisition at the peak of the aortic root enhancement should maximize the coronary enhancement and CNR, potentially improving the accuracy of CT-based assessment of coronary artery disease.
Lifetime reductions and read-out oscillations due to imperfect initial level preparations of atoms in a long-lived DLCZ-like quantum memory
Authors: Wang Minjie , Wang Shengzhi , Xu Zhongxiao , Ma Tengfei , Li Ya , Li Shujing , Wang Hai 
Published: October 2022

AbstractEntanglement between a spin-wave qubit (memory qubit) and a photonic qubit is a basic building block for quantum repeaters. Duan-Lukin-Cirac-Zoller (DLCZ) scheme, which generates spin waves via spontaneous Raman scattering (SRS) of Stokes photons in atomic ensemble, provides a promising way to generate such entanglement. In a recent work [arXiv: 2006.05631, accepted by communications physics], DLCZ-like quantum memory that generates long-lived atom-photon entanglement has been experimentally demonstrated, where magnetic-field-insensitive (MFI) coherence is used to store spin waves. For realizing such MFI spin-wave storage, the atoms have to be initially prepared in a specific Zeeman sublevel, which is achieved by applying optical pumping lasers. Here, we demonstrate the memory lifetimes for the cases that the atoms are perfectly and imperfectly prepared in the specific Zeeman level, respectively. The experimental results show that the spin waves associated with magnetic-field-sensitive (MFS) and MFI coherences will be simultaneously created for the case that the atoms are imperfectly prepared in the Zeeman sublevel. Thus, the read outs will experience decay oscillations due to interferences between the two spin waves and the memory lifetime will be shorten due to dephasing of MFS coherence. A detailed theoretical analysis has been developed for explaining the experimental results. The present work will help one to understand decoherence of spin waves (SWs) and then enable one to obtain optimal lifetime of the entanglement storage in the cold atoms.
Routine application of the Lymph2Cx assay for the subclassification of aggressive B-cell lymphoma: report of a prospective real-world series
Authors: Zamò Alberto , Gerhard-Hartmann Elena , Ott German , Anagnostopoulos Ioannis , Scott David W. , Rosenwald Andreas , Rauert-Wunderlich Hilka 
Published: October 2022

AbstractThe subclassification of diffuse large B-cell lymphoma (DLBCL) into germinal center B-cell-like (GCB) and activated B-cell-like (ABC) subtypes has become mandatory in the 2017 update of the WHO classification of lymphoid neoplasms and will continue to be used in the WHO 5th edition. The RNA-based Lymph2Cx assay has been validated as a reliable surrogate of high-throughput gene expression profiling assays for distinguishing between GCB and ABC DLBCL and provides reliable results from formalin-fixed, paraffin-embedded (FFPE) material. This test has been previously used in clinical trials, but experience from real-world routine application is rare. We routinely applied the Lymph2Cx assay to day-to-day diagnostics on a series of 147 aggressive B-cell lymphoma cases and correlated our results with the immunohistochemical subclassification using the Hans algorithm and fluorescence in situ hybridization findings using break-apart probes for MYC, BCL2, and BCL6. The routine use of the Lymph2Cx assay had a high technical success rate (94.6%) with a low rate of failure due to poor material and/or RNA quality. The Lymph2Cx assay was discordant with the Hans algorithm in 18% (23 of 128 cases). Discordant cases were mainly classified as GCB by the Hans algorithm and as ABC by Lymph2Cx (n = 11, 8.6%). Only 5 cases (3.9%) were classified as non-GCB by the Hans algorithm and as GCB by Lymph2Cx. Additionally, 5.5% of cases (n = 7) were left unclassified by Lymph2Cx, whereas they were defined as GCB (n = 4) or non-GCB (n = 3) by the Hans algorithm. Our data support the routine applicability of the Lymph2Cx assay.
Clinical and radiological outcome 1-year after cervical total disc replacement using the Signus ROTAIO – Prosthesis
Authors: Lang Anna , Lener Sara , Grassner Lukas , Abramovic Anto , Thomé Claudius , Päsler Dennis , Lehmberg Jens , Schär Ralph , Hartmann Sebastian 
Published: October 2022

AbstractIntroductionThe instantaneous center of rotation (iCOR) of a motion segment has been shown to correlate with its total range of motion (ROM). Importantly, a correlation of the correct placement of cervical total disc replacement (cTDR) to preserve a physiological iCOR has been previously identified. However, changes of these parameters and the corresponding clinical relevance have hardly been analyzed. This study assesses the radiological and clinical correlation of iCOR and ROM following cTDR.Materials/methodsA retrospective multi-center observational study was conducted and radiological as well as clinical parameters were evaluated preoperatively and 1 year after cTDR with an unconstrained device. Radiographic parameters including flexion/extension X-rays (flex/ex), ROM, iCOR and the implant position in anterior–posterior direction (IP ap), as well as corresponding clinical parameters [(Neck Disability Index (NDI) and the visual analogue scale (VAS)] were assessed.Results57 index segments of 53 patients treated with cTDR were analyzed. Pre- and post-operative ROM showed no significant changes (8.0° vs. 10.9°;p > 0.05). Significant correlations between iCOR and IP (Pearson’sR: 0.6;p < 0.01) as well as between ROM and IP ap (Pearson’sR: − 0.3;p = 0.04) were identified. NDI and VAS improved significantly (p < 0.01). A significant correlation between NDI and IP ap after 12 months (Pearson’sR: − 0.39;p < 0.01) was found.ConclusionImplantation of the tested prosthesis maintains the ROM and results in a physiological iCOR. The exact position of the device correlates with the clinical outcome and emphasize the importance of implant design and precise implant positioning.
Does leaf mass per area (LMA) discriminate natural pine populations of different origins?
Authors: Buraczyk Włodzimierz , Tulik Mirela , Konecka Agata , Szeligowski Henryk , Czacharowski Marcin , Będkowski Mateusz 
Published: October 2022

AbstractTree provenance trials are believed to be a valuable tool for assessing the adaptive potential of a population to a changing environment and ultimately for predicting the populations that are best adapted to global warming. Here, the phenotypic plasticity of morphometric traits of needles and lateral shoots of pines growing in a provenance plot in central Poland was examined to assess the inter- and intra-population variability. No significant differences were found in the measured and counted morphometric features, i.e., needle length (NL), cumulative needles length (CNL), thickness (ST), volume (SV) and shoot density (SD), number of needles per 5 cm fragment of shoot (NN), dry weight of needles (NDW) and shoot (SDW), thickness of bark (BT) and wood (WT), pith diameter (PD), and needle dry mass per area (LMA) among three pine populations while accounting for their region of origin (inter-population variability). In terms of the above-mentioned features, individual populations differed significantly from each other, except for NN and ST. We also noticed a positive, significant relationship between LMA and ST in all studied populations and based on Euclidean distances of measurable or counted traits, three population groups were identified. We concluded that LMA, which is commonly used to quantify leaf structure, is helpful in differentiating intra-population variability.
An electro-mechanical dynamic model for flexoelectric energy harvesters
Authors: Thai Tran Quoc , Zhuang Xiaoying , Rabczuk Timon 
Published: October 2022

AbstractFlexoelectricity is a universal electro-mechanical coupling effect that occurs in dielectrics of all symmetric groups and becomes dominant at the micro- and nano-scales. It plays an important role in evaluating micro-electro-mechanical systems (MEMS) such as energy harvesters which convert vibrational energy to electric energy. At finer length scales, micro-inertia effects significantly contribute to the behavior of flexoelectric materials due to the mechanical dispersion. Hence, to properly characterize the vibrational behavior of MEMS, a reliable theoretical approach is required accounting for all possible phenomena that affect the output of the system such as voltage or power density. In this work, we present a consistent (dynamic) model and associated computational framework for flexoelectric structures to study the characteristics of the vibrational behavior of energy harvesters showing the dominance of the flexoelectric effect at micro- and nano-scales. In this context, we quantify the impact of the micro-inertia length scale and the flexoelectric dynamic parameter on both frequency and time responses of energy harvesters.
Strukturierte Qualifizierung Sozialer Arbeit im Bereich Palliative Care
Authors: Lehmann Denise , Schütte-Bäumner Christian , Neupert Ingo , Kiepke-Ziemes Susanne 
Published: October 2022

ZusammenfassungDer Beitrag beleuchtet die generalistischen Bildungsstrukturen Sozialer Arbeit und die daraus resultierenden Erfordernisse für ein reflexives, professionelles Handeln im Bereich Palliative Care im Sinne einer strukturierten Qualifizierung sowie im Verständnis eines lebenslangen Lernens mit entsprechend kontinuierlicher Kompetenzentwicklung.
Tolerance for ambiguity, reappraisal, and suppression mediate the relationship between problematic internet use and procrastination
Authors: Emadi Chashmi Seyed Javad , Hasani Jafar , Kuss Daria J. , Griffiths Mark D. , Shahrajabian Fatemeh 
Published: October 2022

Abstract
The current scientific literature lacks studies on the relationship between problematic internet use (PIU) and procrastination, especially regarding the mediating mechanisms underlying this relationship. The present study examined the association between procrastination and PIU, as well as determining the mediating roles of tolerance for ambiguity, reappraisal, and suppression. The conceptual model was tested using data collected from 434 Iranian college students. The participants completed a number of psychometric scales assessing procrastination, PIU, tolerance for ambiguity, reappraisal, and suppression. Structural equation modeling was used to test the hypothesized model. Results showed that PIU, tolerance for ambiguity, and suppression were positively associated with procrastination, and that there was a negative association between reappraisal and procrastination. Moreover, the mediation analysis indicated that tolerance for ambiguity, reappraisal, and suppression fully mediated the association between PIU and procrastination. However, it is also possible to interpret the results as suggesting that PIU is unimportant as a predictor for procrastination once mediators are controlled for.