bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Initial Treatment Adjustments and Complications in Ovarian Cancer Patient With Inborn Error of Immunity
Authors: Mammadova Jamila , Redden Anna , Cruz Rachel , Ujhazi Boglarka , Gordon Sumai , Ellison Maryssa , Gatewood Tyra , Duff Carla , Cannella Anthony , Somboonwit Charurut , Sriaroon Chakrapol , Csomos Krisztian , Dasso Joseph F. , Harville Terry , Ismail-Khan Roohi , Walter Jolan E. 
Published: June 2022

BackgroundPatients with inborn errors of immunity (IEI) have increased risk of developing cancers secondary to impaired anti-tumor immunity. Treatment of patients with IEI and cancer is challenging as chemotherapy can exacerbate infectious susceptibility. However, the literature on optimal cancer treatment in the setting of IEI is sparse.ObjectivesWe present a patient with specific antibody deficiency with normal immunoglobins (SADNI), immune dysregulation (ID), and stage III ovarian carcinoma as an example of the need to modify conventional treatment in the context of malignancy, IEI, and ongoing infections.MethodsThis is a retrospective chart review of the patient’s clinical manifestations, laboratory evaluation and treatment course.ResultsOur patient is a female with SADNI and ID diagnosed with stage III ovarian carcinoma at 60 years of age. Her ID accounted for antinuclear antibody positive (ANA+) mixed connective tissue diseases, polyarthralgia, autoimmune neutropenia, asthma, autoimmune thyroiditis, and Celiac disease. Due to the lack of precedent in the literature, her treatment was modified with continuous input from infectious disease, allergy/immunology and oncology specialist using a multidisciplinary approach.The patient completed debulking surgery and 6 cycles of chemotherapy. The dosing for immunoglobulin replacement therapy was increased for prophylaxis. Chemotherapy doses were lowered for all cycles preemptively for IEI. The therapy included carboplatin, paclitaxel, bevacizumab, and pegfilgrastim. The patient completed six-months of maintenance medication involving bevacizumab.Her treatment course was complicated by Mycobacterium avium-complex (MAC) infection, elevated bilirubin and liver enzymes attributed to excessive immunoglobulin replacement therapy, and urinary tract infection (UTI) and incontinence.Cancer genetic analysis revealed no targetable markers and primary immunodeficiency gene panel of 407 genes by Invitae was unrevealing. Lab tests revealed no evidence of Epstein-Barr Virus (EBV) infection. Post-chemotherapy imaging revealed no evidence of cancer for 1 year and 4 months, but the disease relapsed subsequently. The patient’s lung scarring requires vigilance.ConclusionsOur patient with ovarian cancer and IEI required modified treatment and prevention of complications. In cases of IEI, optimal chemotherapy should be titrated to minimize immunosuppression yet treat cancer aggressively while decreasing the risk of infection with prophylactic antibiotics and prolonged post-treatment surveillance, including pulmonary evaluation.
Compassionate Use of Ripretinib for Patients With Metastatic Gastrointestinal Stromal Tumors: Taiwan and Hong Kong Experience
Authors: Lin Li-Ching , Huang Wen-Kuan , Yen Chueh-Chuan , Yang Ching-Yao , Sung Meng-Ta , Wong Natalie S. M. , Chua Daniel T. T. , Lee Sarah W. M. , Chen Jen-Shi , Yeh Chun-Nan 
Published: June 2022

BackgroundRipretinib was recently approved for the fourth-line targeted therapy for advanced gastrointestinal stromal tumor (GIST) refractory to imatinib, sunitinib, and regorafenib based on the pivotal INVICTUS phase III study. The INVICTUS study demonstrated significantly improved median progression-free survival (PFS) of 6.3 months and an overall survival (OS) insignificant benefit of ripretinib of 15.1 months as compared with placebo in 85 patients with advanced metastatic GIST. However, treatment outcome for the Chinese population, including in Taiwan and Hong Kong, was lacking.Material and MethodA compassionate study regarding ripretinib use for patients with advanced/metastatic GIST was conducted from March 2020 to March 2021 to assess the treatment efficacy and safety in Taiwan and Hong Kong patients.ResultTwenty evaluable patients (16 men and 4 women) with heavily pretreated metastatic GIST receiving ripretinib from March 2020 to March 2021 were enrolled to evaluate the treatment outcome. The response and clinical benefit rates to ripretinib were 25% (5/20) and 60% (12/20), respectively. The median PFS and OS in this compassionate cohort receiving ripretinib were 6.1 months and not reachable, respectively. Albumin less than 3.5 and disease progression after ripretinib use were the two independent unfavorable factors for PFS. There were 14 out of 20 (70%) experiencing any grade adverse event (AE). Loss of hair is the most common grade I to II AE with an incidence of 55%. Grade III AEs included diarrhea, skin rash, and anemia with one patient (5%) for each AE.ConclusionsLate-line ripretinib use in pretreated Taiwan and Hong Kong patients with advanced GIST showed efficacy consistent with the INVICTUS study. Albumin less than 3.5 and disease progression after ripretinib use were the two independent unfavorable factors for PFS. Ripretinib is generally tolerable, with loss of hair being the most common AE.
The Management of Intraabdominal Testis: A Survey of the World Federation of Associations of Pediatric Surgeons (WOFAPS) Practices
Authors: Shehata Sameh , Hadziselimovic Faruk , Khater Doaa , Kotb Mostafa 
Published: June 2022

Background and ObjectiveThe optimal treatment protocol of intraabdominal testis is still a matter of debate and until now there are a lot of areas of controversy as regards this challenging subtype. The aim of this report is to document current practice patterns among surgeons from different continents through an online Redcap survey supervised the World Federation of the Association of Pediatric Surgeons (WOFAPS).MethodsA 16-question-survey related to the management of intraabdominal testis was created and administered via RedCap. The WOFAPS headquarters sent an email to all members inviting voluntary survey participation. Data were entered using Microsoft EXCEL spreadsheet and analyzed. Descriptive statistics were performed for each survey item.ResultsThere were 436 WOFAPS members who participated in this study with a response rate of 29%, and the vast majority were pediatric surgeons. Only 13% tried to use hormone therapy aiming to induce testicular descent or to improve future fertility. The choices of various surgical techniques were noted. During laparoscopy, if vessels and cord structure were seen entering the ipsilateral internal inguinal ring, most respondents chose to explore the groin. On the other hand, should there was an absent or atrophic testis, the respondents were split on whether to perform a contralateral orchiopexy.ConclusionThis survey describes the current practices of a sample of pediatric surgeons and urologists in the management of intraabdominal testis. The use of hormonal treatment, timing of fixation and management in case of passing through vas and vessels through DIR were undisputable. However, management of low-lying and peeing testis together with the management of contralateral testis were still debatable.
Differential Branchial Response of Low Salinity Challenge Induced Prolactin in Active and Passive Coping Style Olive Flounder
Authors: Zeng Junjia , Li Jie , Yang Kun , Yan Jiayu , Xu Tianchun , Lu Weiqun 
Published: June 2022

Stress coping styles are very common in fish, and investigations into this area can greatly improve fish welfare and promote the sustainable development of aquaculture. Although most studies have focused on the behavioral and physiological differences of these fishes, the endocrine response of different coping styles fish when undergoing salinity challenge is still unclear. We examined the physiological response in olive flounder with active coping (AC) style and passive coping (PC) style after transferred from seawater (SW) to freshwater for 0, 2, 5, 8, and 14 days. The results showed that: 1) the plasma prolactin level of FW-acclimated AC flounder was substantially higher than that of FW-acclimated PC flounder at 5, 8, and 14 days, and the branchial gene expression of prolactin receptor (PRLR) in AC flounder was slightly higher than PC flounder after transfer. While there was no remarkable difference observed in cortisol (COR) levels between AC and PC flounder. After transfer, glucocorticoid receptor (GR) expression in AC flounder was significantly higher compared with PC flounder at 8 days. 2) Branchial NKA-IR ionocytes numbers were reduced in PC flounder after transfer, while ionocytes number remain stable in AC flounder. 3) The branchial stem cell transcription factor foxi1 gene expression of AC flounder was significantly higher than PC flounder at 2, 5, and 14 days after transfer, while branchial stem cell transcription factor p63 gene expression of FW-acclimated AC flounder was only substantially higher than that of PC flounder at 5 days. 4) As an apoptosis upstream initiator, the branchial gene expression of caspase-9 in PC flounder was considerably higher than in AC flounder after transfer at 8 days. This study revealed that olive flounder with active and passive coping styles have different endocrine coping strategies after facing the low-salinity challenge. AC flounder adopt an active endocrine strategy by increasing ionocyte differentiation and prolactin secretion significantly. In contrast, PC flounder employ a passive strategy of reducing ionocytes differentiation and retaining prolactin content at a low level to reduce branchial ionocytes number.
Development and Validation of Simplified Delirium Prediction Model in Intensive Care Unit
Authors: Kim Min-Kyeong , Oh Jooyoung , Kim Jae-Jin , Park Jin Young 
Published: June 2022

BackgroundThe intensive care unit (ICU) is where various medical staffs and patients with diverse diseases convene. Regardless of complexity, a delirium prediction model that can be applied conveniently would help manage delirium in the ICU.ObjectiveThis study aimed to develop and validate a generally applicable delirium prediction model in the ICU based on simple information.MethodsA retrospective study was conducted at a single hospital. The outcome variable was defined as the occurrence of delirium within 30 days of ICU admission, and the predictors consisted of a 12 simple variables. Two models were developed through logistic regression (LR) and random forest (RF). A model with higher discriminative power based on the area under the receiver operating characteristics curve (AUROC) was selected as the final model in the validation process.ResultsThe model was developed using 2,588 observations (training dataset) and validated temporally with 1,109 observations (test dataset) of ICU patients. The top three influential predictors of the LR and RF models were the restraint, hospitalization through emergency room, and drainage tube. The AUROC of the LR model was 0.820 (CI 0.801–0.840) and 0.779 (CI 0.748–0.811) in the training and test datasets, respectively, and that of the RF model was 0.762 (CI 0.732–0.792) and 0.698 (0.659–0.738), respectively. The LR model showed better discriminative power (z = 4.826; P &lt; 0.001).ConclusionThe LR model developed with brief variables showed good performance. This simplified prediction model will help screening become more accessible.
Investigating Predictive Factors of Suicidal Re-attempts in Adolescents and Young Adults After a First Suicide Attempt, a Prospective Cohort Study. Study Protocol of the SURAYA Project
Authors: Abrial Erika , Chalancon Benoît , Leaune Edouard , Brunelin Jérôme , Wallon Martine , Moll Frédéric , Barakat Nadine , Hoestlandt Benoit , Fourier Anthony , Simon Louis , Magnin Charline , Hermand Marianne , Poulet Emmanuel 
Published: June 2022

IntroductionSuicide is the fourth leading cause of death in youth. Previous suicide attempts are among the strongest predictors of future suicide re-attempt. However, the lack of data and understanding of suicidal re-attempt behaviors in this population makes suicide risk assessment complex and challenging in clinical practice. The primary objective of this study is to determine the rate of suicide re-attempts in youth admitted to the emergency department after a first suicide attempt. The secondary objectives are to explore the clinical, socio-demographic, and biological risk factors that may be associated with re-attempted suicide in adolescents and young adults.MethodsWe have developed a single-center prospective and naturalistic study that will follow a cohort of 200 young people aged 16 to 25 years admitted for a first suicide attempt to the emergency department of Lyon, France. The primary outcome measure will be the incidence rate of new suicide attempts during 3 months of follow-up. Secondary outcomes to investigate predictors of suicide attempts will include several socio-demographic, clinical and biological assessments: blood and hair cortisol levels, plasma pro- and mature Brain-Derived Neurotrophic Factor (BDNF) isoforms proportion, previous infection with toxoplasma gondii, and C-Reactive Protein (CRP), orosomucoid, fibrinogen, interleukin (IL)-6 inflammatory markers.DiscussionTo our knowledge, the present study is the first prospective study specifically designed to assess the risk of re-attempting suicide and to investigate the multidimensional predictive factors associated with re-attempting suicide in youth after a first suicide attempt. The results of this study will provide a unique opportunity to better understand whether youth are an at-risk group for suicide re-attempts, and will help us identify predictive factors of suicide re-attempt risk that could be translated into clinical settings to improve psychiatric care in this population.Clinical Trial RegistrationClinicalTrials.gov, identifier: NCT03538197, first registered on 05/29/2018. The first patient was enrolled 05/22/2018.
Technology and Older Women: Considerations Regarding Their Use and Misuse
Authors: Heine Chyrisse , Feldman Susan 
Published: June 2022

Health and wellbeing are inextricably linked to an individual's capacity for continued meaningful engagement and connection with the world around them. Technological innovations designed to maximize the quality of life for older women range from sophisticated bio-medical interventions to ordinary day-to-day communication devices. Many innovations can ensure a higher quality of life for older women and support and care as required.In this article, we consider: (1) The range of appropriate technologies currently available for older women, their families and communities. (2) The way technology contributes to the maintenance of optimum physical health and wellbeing for older women. (3) The significant challenges and considerations associated with the incorporation of technologies into their daily lives.
Case Report: Multilevel Ossification of the Ligamentum Flavum in a Patient With Spinal Osteoblastoma
Authors: Montgomery Canada T. , Miranda Stephen P. , Nelson Ernest , Louka Katie , Nasrallah MacLean , Zhang Paul J. , Stein Joel , Petrov Dmitriy 
Published: June 2022

IntroductionSpinal osteoblastomas are primary benign bone tumors most commonly presenting as diffuse back pain in young adults. Rarely, spinal osteoblastoma is associated with ossification of the ligamentum flavum (OLF), a form of ectopic bone formation, which can present with myelopathy. This report highlights a unique case of a patient with spinal osteoblastoma, associated OLF, and thoracic myelopathy.Case DescriptionThe patient presented with subtle myelopathy consisting of mid-thoracic back pain, paresthesias, and gait instability. Imaging findings were suggestive of spinal osteoblastoma with multifocal OLF. The patient was consented for thoracic decompression and stabilization at the T6-10 levels. Histopathology confirmed osteoblastoma with associated OLF. At follow up, the patient’s neurological symptoms had completely resolved.ConclusionThis case describes management for a rare presentation of osteoblastoma with associated OLF and myelopathy. Surgeons should be wary of disproportionate neurological compromise when spinal osteoblastoma is associated with OLF. Further study is required to elucidate the pathogenesis of this condition.
Environmental Ethics of Kaki Air Village Community at Teluk Kaiely District Buru Regency
Authors: Fatimah Fatimah , Susiati Susiati , Jelira Noch Fernando , Umanailo Chairul Basrun , Bin Tahir Saidna Zulfikar 
Published: June 2022

The purpose of this research is to 1) identify the community's ethical principles and 2) identify the variables that contribute to the establishment of community environmental ethics in Kaki Air Village. This study employs a qualitative descriptive method with a phenomenological orientation. The statistics were compiled through primary and secondary sources, with the major source being the residents of Kaki Air VillageThis study included non-participatory observation and field survey techniques (field study), as well as interviews (interviews), documentation studies, and literature research.. The data analysis step entails the reduction of data, its display, verification, and analysis. The study's findings indicate that the residents of Kaki Air Village have a particular brand of environmental ethics, namely that 1) humans are a part of nature. The visible qualities are divine values in this type of ethics; 2) nature is not to be dominated. This ethics upholds the virtue of politeness; 3) Support of other animals' rights to life. Concerning the ideals engendered by this ethics, namely the value of oneness; 4) exposing flaws in the maintenance system. This ethic is based on human and cultural values; 5) nature must be conserved. The ideals included in this ethics, particularly the value of wisdom and traditional values; 6) environmental stewardship. The principles created by this ethics are those of care and wisdom; 7) respect for the environment. The values produced by this ethic are those of concern and traditional values. The following elements contribute to the development of environmental ethical principles in the Kaki Air Village community: 1) attitude of the public; 2) natural environment; 3) regulation; 4) customs; 5) traditions; 6) sasi (Customary Law); 7) mata kao; 8) belief in the sacred; 9) belief in the landlord.
Postmodernism in The Art Concept of Putu Wijaya
Authors: Abidin Aslan , Rahman Nurhayati , Lewa Inriati 
Published: June 2022

This research will explore the life journey of a prominent Indonesian writer, Putu Wijaya. His life history is traced especially his connetion to traditionality and modernity, starting from childhood until graduating from high school in Bali, as a student to his graduation in Yogyakarta, then moving to settle and making art in Jakarta. The three places gave him an intense understanding of the traditionalities of Bali, Java, and the Archipelago. At the same time, the three places also provide him with an understanding of modernity. The various forms of traditionality and modernity mingled in Wijaya’s works, traditionalities such as fairy tales, wayang stories, and even mystical things that do not make sense also influence Wijaya's way of thinking. Meanwhile, one of the important modernities that also influenced him since childhood was Indonesian language. The language was chosen and designed based on the modern thinking of linguists Von de Wall, HC Klinkert, and Van Ophuijsen from the Dutch colonial state. Wijaya's mingling of traditionality and modernity allows him to write fluently various things, including the absurd and the absurd. His understanding of himself and his readers who were victims of feudalism and colonialism, made him write literary works to make his readers think more freely. This makes Wijaya's literary works tend to have a postmodernist style
Pengembangan Oleogel dengan Memanfaatkan Hydrocolloids dari Berbagai Sumber Sebagai Gelling Agent
Authors: Trirahayu Dhyna Analyes , Ridwan P. Putra  , Abidin Akhmad Zainal 
Published: June 2022

Minyak dan lemak dapat dijumpai dalam berbagai bentuk, dapat berupa cairan encer hingga kental, lemak yang dapat dioles hingga yang berbentuk padatan kaku. Bentuk fisik dari minyak dan lemak ini menentukan bagaimana minyak dan lemak ini dapat digunakan dan proses yang dibutuhkan untuk pemanfaatannya. Oleogel merupakan gel yang memiliki fasa cair berupa minyak, berbeda dengan hidrogel, memiliki air sebagai fasa cair. Potensi pemanfaatn oleogel sangat beragam seperti di industri makanan, farmasi, kosmetik, dan petrokimia. Dalam proses pembentukan oleogel diperlukan gelling agents. Gelling agents dapat diperoleh dari bahan yang termasuk ke dalam kelompok hydrocolloids. Bahan hydrocolloids dapat berasal dari berbagai sumber nabati maupun hewani. Penelitian ini bertujuan untuk melakukan pengamatan pengaruh kombinasi gelling agent terhadap pembentukan oleogel berbasis minyak minyak biji bunga matahari. Pembentukan oleogel dilakukan menggunakan kombinasi gellin agent berupa hydroxypropyl methyl cellulose (HPMC), xanthan gum (XG), guar gum (GG), arabic gum (AG) dengan komposisi yang divariasikan. Produk oleogel yang stabil kemudian dianalisis berupa analisa oil loss. Berdasarkan kombinasi gelling agent yang digunakan, hanya kombinasi HPMC:XG yang menghasilkan oleogel yang stabil. Oleogel terbaik diperoleh menggunakan kombinasi gelling agent HPMC : XG = 1 : 1 dengan jumlah 2 gr (2% b/b) dengan oil loss sebesar 3,99%.
Coaxyl-mask: Masker Ramah Lingkungan dari Sabut Kelapa (Cocos nucifera) dan Acetobacter xylinum
Authors: Setyaningrum Sinta , Salsabila Zahra Nur , Auliya Rahmawati Aisyah , Indrita Putri Anindya , Nurul Amalia Dhea , Athiya Tsany Syakira 
Published: June 2022

Penggunaan masker bagi setiap orang dinilai efektif untuk membatasi penyebaran Covid-19. Namun, permasalahan lingkungan muncul akibat dari banyaknya penggunaan masker karena masker sekali pakai sulit untuk terurai secara alami. Maka dari itu, Coaxyl-mask merupakan inovasi masker sekali pakai yang terbuat dari bioselulosa hasil fermentasi Acetobacter xylinum dan sabut Cocos nucifera. Masker ini terdiri dari 3 lapisan yaitu film bioselulosa yang memiliki sifat water repellent, filter sabut kelapa, dan film bioselulosa sehingga mampu terdekomposisi dengan cepat jika dibandingkan dengan masker sekali pakai pada umumnya. Pada gagasan yang diusulkan ini, perancangan teknik implementasi Coaxyl-mask yaitu dengan melibatkan banyak pihak seperti, pedagang kelapa, produsen masker, tim riset perusahaan medis, dan pabrik independen. Diprediksi masker ini akan memiliki manfaat yang panjang sebagai alat pelindung pada saat pandemi dan mampu menjadi solusi dalam menangani pencemaran atau penimbunan masker seiring dengan jumlah pemakai yang banyak.
Wearing masks has been proven to be the most effective in preventing and minimising the spread of Covid-19. However, there is an environmental risk along with the growing demand of single-use masks. This is caused as the single use mask waste cannot be degraded naturally. Therefore, Coaxyl-mask is a green innovation of masks that is made from biocellulose produced by fermentation of glucose using Acetobacter xylinum and coconut husk waste. This mask is made of three layers of water repellent biocellulose film, a filter made from coconut husk, and another biocellulose film that is non-irritative to the skin. As the materials were made of natural materials, this mask can degrade naturally faster compared to conventional single use masks, so it is environmentally friendly. To implement this idea, there need to be a lot of party involved such as coconut seller, mask producers, medical equipment research team, and independent factories. Because its biodegradable materials, this mask will be a revolutionary invention in medical industry and will be very useful in preventing diseases while saving the environment.