bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Percutaneous Tibial Nerve Stimulation Effective and Safety for Treating and Managing Faecal Incontinence (FI) Compared to Sham Electrical Stimulation? A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Luo Can , Yue Fuping , Han Yixian , Wei Dongmei , Pang Kaiyin , Niu Xiaoyu 
Published: September 2022

Abstract
Purpose
Sacral Nerve Stimulation (SNM) was seen the best second-line treatment for Faecal incontinence (FI). However, expensive, twice operations and complicated procedures blocked the spread of SNM. Percutaneous Tibial Nerve Stimulation (PTNS) were gradually applied to FI with different clinical outcomes, so we conducted a systematic review and meta-analysis of randomized controlled trials to invest the efficacy and safety of PTNS versus sham electrical stimulation for the treatment of FI.
Method
We searched electric databases including Pubmed, Embase, Web of Science and Cochrane library. All the studies were limited to randomized controlled trails (RCTs) without limitation about region and race.
Results
Four randomized controlled studies were included in this review, which involved 441 FI adult patients (302 of them received PTNS versus 194 underwent sham electrical stimulation. Our Meta-Analysis showed that PTNS can better reduce the episodes of FI per week compared to control groups (MD=-1.57, 95%CI -2.97 to -0.17, p = 0.03, I2 = 31%). More patients reported more than 50% reductions in FI episodes per week after PTNS (RR = 1.32, 95%CI 1.01 to 1.73, p = 0.04, I2 = 6%). No significant differences existed in any domains of the FI Quality of Life and St Mark’s incontinence scores (MD=-1.44, 95%CI -3.55 to 0.68, p = 0.18, I2 = 81%). No sever events related PTNS had been reported in all participants.
Conclusion
Compared with sham groups, our Meta-analysis demonstrated that PTNS can better reduced FI episodes, but no differences existed in St Mark’s incontinence scores and FI Quality of Life. In the future, multicentric and well-designed trials with longer follow-up periods will be conducted to confirm our conclusions.
Removal efficiencies of emissions of volatile organic compounds by adsorption systems installed in small-scale auto-repair painting operations
Authors: Chun Haejoon , Song Min Young 
Published: September 2022

Abstract
Total hydrocarbon (THC), including volatile organic compounds (VOCs), is emitted during the operations of an auto-repair painting workshop. VOCs are especially hazardous pollutants because of their impacts on ozone formation and human health. To reduce the THC generated from small auto-repair painting shops, the Korean government conducts a support program to enable them to shift from an old to a new adsorption system. Although lab-scale evaluations of the pollutant reduction efficiencies of some adsorption devices have been carried out, actual field evaluations are lacking. In this study, three auto-repair shops (one with an old and two with new air pollutant adsorption systems) in Seoul were selected to evaluate their removal efficiencies with respect to THC and VOCs during painting and drying operations. Results show that the THC removal efficiencies were − 41.3–35.4% and 17.2 − 59.2% for the old and new adsorption systems, respectively. The removal efficiencies of the top five VOC species such as butyl acetate, toluene, 1,2,3-trimethylbenzene, m,p-xylene, and ethylbenzene were positive (+) and negative (−) for the new and old adsorption systems, respectively. These results provide a theoretical basis that endorses the government support policy for the removal of air pollutants from the emissions of small businesses that are not well managed, such as auto-repair painting, printing, and dry cleaning.
Antimicrobial resistance of Staphylococcus spp isolated in dairy farms and its relationship with the antimicrobial control and treatment of bovine mastitis
Authors: Rodríguez Martha Fabiola , Gomez Arlen Patricia 
Published: September 2022

Abstract
Antimicrobial resistance (AMR) of Staphylococcus strains from dairy farms has been attributed to the use of antibiotics in humans and animals. We conducted this research to identify the AMR genotypes and phenotypes of Staphylococcus spp isolates from different sources on dairy farms and their relationship with the control and treatment of mastitis. Antimicrobial susceptibility test was performed on 349 Staphylococcus isolates, identified by Vitek® 2 compact automated system and Maltitoff, from milk of cows with subclinical mastitis, teats of cows with and without mastitis, nasal mucosa of workers, and the environment of dairy farms. AMR genes were identified in S. aureus isolates by PCR. 152 S. aureus and 197 non-aureus staphylococci (NAS) showed resistance mainly to penicillin (54.1% and 32.4%) and ampicillin (50.3% and 27.0%), which was associated with the use of these antibiotics on farms. S. aureus isolated from workers and the environment exhibited significantly higher AMR compared to β-lactams. The identification of the blaZ (83.9%), aacA-aphD (48.6%), ermC (23.5%), tetK (12.9%) and mecA (11.8%) genes in S. aureus had low correspondence with the AMR phenotype. We conclude that the use of β-lactam antibiotics influences the expression of AMR on Staphylococcus circulating in dairy farms and that environmental and human isolates of S. aureus may be involved in the persistence of resistant strains in dairy farms.
Towards a High-density Photonic Tensor Core Enabled by Intensity-modulated Microrings and Photonic Wire Bonding
Authors: Luan Enxiao , Yu Shangxuan , Salmani Mahsa , Nezam Mohammadreza , Shastri Bhavin , Chrostowski Lukas , Eshaghi Armaghan 
Published: September 2022

Abstract
We propose a photonic processing unit for high-density analog computation using intensity-modulation-based microringmodulators (IM-MRMs). The output signal at the fixed resonance wavelength is directly intensity modulated by changing theextinction ratio (ER) of the IM-MRM. Thanks to the intensity-modulated approach, the proposed photonic processing unit isless sensitive to the inter-channel crosstalk. Simulation results reveal that the proposed design offers a maximum of 17-foldincrease in wavelength channel density compared to its wavelength-modulated counterpart. Therefore, a photonic tensor coreof size 512 × 512 can be realized by current foundry lines. A convolutional neural network (CNN) simulator with 6-bit precisionis built for handwritten digit recognition task using the proposed modulator. Simulation results show an overall accuracy of 96.76%, when the wavelength channel spacing suffers a 3-dB power penalty. To experimentally validate the system, 1000 dotproduct operations are carried out with a 4-bit signed system on a co-packaged photonic chip, where optical and electrical I/Osare realized using photonic and electrical wire bonding techniques. Study of the measurement results show a mean squarederror (MSE) of 3.09 × 10^−3 for dot product calculations. The proposed IM-MRM, therefore, renders the crosstalk issue tractableand provides a solution for the development of large-scale optical information processing systems with multiple wavelengths.
Achieving a long-life 165 Wh/kg sodium-ion pouch-cell via regulating intergrowth structure in layered oxide cathode with anionic redox
Authors: Qiao Yu , Wang Xiaotong , Zhang Qinghua , Zhao Chen , Li Haifeng , Zhang Baodan , Zeng Guifan , Tang Yonglin , Huang Zhonghuan , Hwang Inhui , Zhang Haitang , Zhou Shiyuan , Qiu Yongfu , Xiao Yinguo , Cabana Jordi , Sun Cheng-Jun , Amine Khalil , Wang Qingsong , Xu Gui-Liang , Gu Lin , Sun Shi-Gang 
Published: September 2022

Abstract
The Na-O-Li configurations in P2-type sodium layered transition metal (TM) oxide cathode can trigger additional oxygen redox at high charging voltage (deep de-sodiation). However, the P-type to O-type phase transition and irreversible TM migration would be simultaneously aggravated at high state-of-charge, resulting in structural distortion. Herein, we demonstrate that excessive de-sodiation of Na0.67Li0.1Fe0.37Mn0.53O2 (NLFMO) induces Li removal from lattice and the formation of neighboring O-stacking faults with an OP4-O2 intergrowth structure, which is the chief culprit of structural distortion. Regulating Li migration from the pristine TM layer (LiTM) to the alkali-metal layer (LiAM) would sustain a repetitive P-stacking state (not evolve into a deteriorated neighboring O-stacking), and tune the reversible movement of TM ions during cycling. Accurately regulating the O/P-intergrowth structure (within the OP4 boundary phase) does not bring any obvious trade-off on capacity, but enhances the structural stability of NLFMO cathode, achieving a long-life 165 Wh/kg pouch-cell with cationic/anionic redox activities.
Fabrication and in vitro assessment of a biomimetic tri-layer PGS/PCL scaffold loaded with Heparin and PRP for tissue engineering of vascualar grafts
Authors: Ghebleh Ayda , Kharazi Anousheh Zargar 
Published: September 2022

Abstract
The most important challenges in tissue engineering of vascular graft (for under 6 mm diameter grafts) is attributed to the inability to remodeling and the patency of the graft. In this research, functionally graded materials are designed to mimic naturally occurring structure in the vessels and a new biomimetic scaffold whit simultaneous release of anti-clotting drugs and growth factors was designed to overcome the mentioned challenges. The scaffold was made of PGS/PLA blend in three layers, where the ratio of the polymers was 3:1 in the inner layer, 2:1 in the middle layer, and 1:1 in the outer layer. Heparin as an anticoagulant and Platelet Rich Plasma (PRP) as a growth factor release function was loaded in the middle and inner layers respectively. The scaffold was evaluated from Physical, mechanical, drug release, hemocompatibility and cytotoxicity characterization. Results showed that adding drugs, disturb uniformity of the fibers. It also improved hydrophilicity of the scaffold. The tri-layer scaffold showed a 40 % weight loss after 30 days of soaking in PBS but no delamination was seen in the samples. Ultimate tensile strength (UTS) and elastic modulus of tri-layer scaffold containing dugs were 0.798±0.103 Mpa and 13.8±1.11 MPa respectively. The integrity of the layers was preserved due to the gradual change in the composition from the inner to the outer layer. The scaffold showed no cytotoxicity also fully blood compatibility. This three-layer biomimetic scaffold can promise to achieve ideal tissue engineering vascular grafts however, more preclinical evaluation should be performed in future research.
Specific contamination symptoms are associated with experiencing a limited response of cognitive-behavioral therapy in pediatric patients with OCD
Authors: Duholm Charlotte Steen , Jensen Sanne , Rask Charlotte Ulrikka , Thomsen Per Hove , Ivarsson Tord , Skarphedinsson Gudmundur , Torp Nor Christian , Weidle Bernhard , Nissen Judith Becker , Højgaard Davíð R.M.A 
Published: September 2022

Abstract

A recent study identified three distinct OCD treatment-response trajectories during and after treatment in a large pediatric sample, where higher levels of contamination symptoms predicted a limited response to cognitive-behavioral therapy (CBT). This study is an extension of this, examining what characterizes limited responders to CBT regarding contamination symptoms from baseline to 3-year follow-up. The study sample comprised 269 patients with OCD, aged 7–17 years. All participants received stepped-care treatment with manualized CBT. Differences in single item-reporting between the three groups was examined using linear mixed-effect modeling. Limited responders were characterized by a higher symptom load across all OCD symptom categories at 3-year follow-up, dominated by contamination symptoms. In the limited responder group, five contamination items showed persistence from baseline to 3-year follow-up. The results indicate that specific contamination symptoms may play an important role for a certain group of young patients with OCD and their response to CBT.
Seasonal household variation in harvested rainwater availability in Siaya County, Kenya: a modelling analysis
Authors: Wright Jim , Yu Weiyu , Wanza Peggy , Kwoba Emmah , Mwangi Thumbi , Okotto-Okotto Joseph , Silva Diogo Trajano Gomes da 
Published: September 2022

Abstract
Rainwater harvesting reliability, the proportion of days annually when rainwater demand is fully met, is challenging to estimate from cross-sectional household surveys that underpin international monitoring. This study aims to develop and evaluate a rainwater harvesting reliability model that integrates household surveys with gridded precipitation data. We interviewed 234 households in rural Siaya County, Kenya in two survey campaigns, administering a standard questionnaire that also identified the source of household stored drinking-water. Logistic mixed effects models estimated stored rainwater availability from household and climatological variables, with random effects accounting for unobserved heterogeneity. Household rainwater availability was significantly associated with seasonality, storage capacity, and access to alternative improved water sources. Most households (96.9%) that consumed rainwater faced insufficient supply of rainwater available for potable needs throughout the year, with intermittencies during the short rains for most households with alternative improved sources. Although not significant, stored rainwater lasts longer for households whose only improved water source was rainwater (299.6 ± 50.7 days) compared to those having multiple improved sources (136.3 ± 81.3 days). Such modelling analysis could enable rainwater harvesting reliability estimation, and thereby targeted follow-up fieldwork to support rainwater harvesting.
E-CropReco: A Dew-Edge-based Multi-parametricCrop Recommendation Framework for Internet ofAgricultural Things
Authors: Bera Somnatha , Dey Tanushree , Mukherjee Anwesha , Buyya Rajkumar 
Published: September 2022

Abstract
Crop productivity prediction and recommendation is a significant research area of smart agriculture. This paper proposes an Internet of Things (IoT) framework based on dew computing, edge computing, and federated learning, where soil parameter, weather, and climate data are analysed to predict the crop productivity of a land, and then recommend suitable crop for the land. The dew layer pre-processes and accumulates the received sensor data, and forwards to the edge server. The edge server analyses the sensor data and the climate data, and then forwards the result along with the model characteristics to the cloud for further analysis. The proposed framework is simulated in iFogSim. The theoretical analysis shows that the proposed framework has reduced the delay by 60-70% approximately and power consumption by 70-80% approximately than the conventional IoT-cloud framework. We also observe that the proposed framework has reduced the delay by 12-35% approximately and power consumption by 30-50% approximately than the edge-cloud framework. We compare four machine learning algorithms based on their performance in data analysis in terms of precision, recall, accuracy, and F-Score. We observe that each classifier obtains more than 95% prediction accuracy. An Android application is also proposed for crop recommendation.
Identification of network-based differential gene expression signatures and their transcriptional factors to develop progressive blood biomarkers for Alzheimer’s disease
Authors: Jayaswamy Pavan K , Gollapalli Pavan , Alexander Lobo Manuel , M Vijaykrishnaraj , Patil Prakash , Shetty Praveenkumar 
Published: September 2022

Abstract

Background: Alzheimer's disease (AD) can go years without being undiagnosed due to a lack of biomarker identification with a growing incidence rate in the geriatric population. Identifying genes and their transcriptional factors and kinases that regulate the phosphorylation and pathogenesis of AD is a state-of-art approach to identifying novel diagnostic biomarkers.
Methodology: Microarray dataset GSE140829 was retrieved from the GEO database to identify differentially expressed genes (DEGs) between AD and control samples. Furthermore, a protein interaction network was built using the String database, and DEGs were examined using Cytoscape based on high betweenness centrality (BC) and degree values. Additionally, the hub genes were identified via Cytohubba, and eight modules were then identified using molecular complex detection (MCODE).
Results:
Using a Venn diagram, we mined 1674 common DEGs from AD and control samples. The primary interaction data from the STRING consists of 1198 nodes and 1992 edges, which serve an extenuated network. Further, a core network was extracted from an extended network that consists of 676 nodes connected via 1955 edges and were analyzed based on high BC and Degree values. Based on the network topological analysis and network clustering, the hub genes were identified and further validated by coparing them with the backbone network. Compelling results from both the core network and backbone network HSP90AA1identified as a major blood biomarker, followed by HSPA5, CREBBP, UBC, GRB2, MAPK3, and TRAF6 are selected as the major biomarkers.
Conclusion:
This study shows the potential for predicting AD risk factors and identifies promising blood biomarkers for early AD diagnosis. Additionally, developing inhibitors for the identified transcriptional factors and kinases might improve future therapeutic applications.
Transcriptome Analysis of the Mouse Medial Prefrontal Cortex in Chronic Constriction Injury Model: Implications of neuropathic pain-induced cognitive impairment
Authors: Zheng Qi-Min , Zhou Zi-Rui , Hou Xin-Yu , Lv Ning , Zhang Yu-Qiu , Cao Hong 
Published: September 2022

Abstract
Chronic pain patients often complain their decreased cognitive function. However, the comorbidity mechanism between neuropathic pain and cognitive dysfunction still remains largely unknown. Here, we examined changes in the transciptomic profiles in the medial prefrontal cortex (mPFC) of mice with chronic pain and cognitive impairment using RNA sequencing (RNA-seq) technology. A mouse model of peripheral neuropathic pain was induced via chronic constriction injury (CCI) of the sciatic nerve. CCI mice developed sustained mechanical allodynia and thermal hyperalgesia, as well as cognitive impairment four weeks after surgery. Comparing with the naïve group, RNA-seq identified a total 309 and 222 differentially expressed genes (DEGs) in ipsilateral and contralateral mPFC of CCI model mice, respectively. GO analysis indicated that the functions of these gene families are mainly enriched in immune and inflammation-related processes such as interferon-gamma production, cytokine secretion etc. KEGG analysis further showed the enriched neuroactive ligand-receptor interaction signaling pathway and Parkinson disease pathway that have been reported to be importantly involved in chronic neuralgia and cognitive dysfunction. Our study may provide insights into understanding the possible mechanisms underlying pain-related cognitive disorders.
Psychometric analysis of the Treatment Self-Regulation Questionnaire-Persian (TSRQ-P) version: autonomous regulation appraisal among the Iranian type 2 diabetes patients
Authors: Matin Habibeh , Sarbakhsh Parvin , Shaghaghi Abdolreza 
Published: September 2022

Abstract

Background: Autonomous self-regulation is a proxy for adapting long-term healthy behaviors with major impact on prevention of chronic illnesses. The psychometric properties of the Treatment Self-Regulation Questionnaire- Persian version (TSRQ-P) was assessed in this study for use in examination of autonomous regulation among the Iranian type 2 diabetes patients.
Methods: The preliminary draft of the TSRQ-P was prepared based on a standard translation/back translation procedure and 15 allied health specialists assessed its face and content validities. The internal consistency measure of the Cronbach’s alpha and Intraclass Correlation Coefficient (ICC) were estimated to verify the TSRQ-P’s content validity and reliability. The exploratory (EFA) and confirmatory factor (CFA) analyses were performed to check the scale’s structural components.
Results: The calculated Cronbach’s alpha= 0.893 and ICC= 0.982 deemed the scale as content valid and acceptable in terms of measurement invariance. The EFA and CFA outputs yielded two distinct factor structure for the TSRQ-P (RMSEA=0.078, NFI=0.849, RFI=0.806, IFI=0.913, TLI=0.886, CFI= 0.911).
Conclusion: The TSRQ-P indicated robust psychometric features for application among Persian-speaking type 2 diabetes patients. Due to cross-borders cultural diversity of the subgroups of Persian speaking populations, further psychometric scrutiny is recommended to prevent bias and sociolinguistic inconsistencies.
Comparison of treatment outcomes of 360° intraoperative laser retinopexy and focal laser retinopexy with pars plans vitrectomy in patients with primary rhegmatogenous retinal detachment
Authors: Zheng Ying , Schindler Philip , Druchkiv Vasyl , Schulz Jan , Spitzer Martin , Christos Skevas 
Published: September 2022

Abstract
Background
This study was to compare the outcomes of 360° intra-operative laser retinopexy (ILR) and focal laser retinopexy in treating patients with pars plans vitrectomy (PPV) for primary rhegmatogenous retinal detachment (RRD). To identify other potential risk factors for retinal re-detachment after primary PPV.
Methods
This was a retrospective cohort study. Three hundred and forty-four consecutive cases of primary rhegmatogenous retinal detachment treated with PPV were included between July 2013 and July 2018. Clinical characteristics and surgical outcomes were compared between focal laser retinopexy and additional 360° intra-operative laser retinopexy groups. Both univariate and multiple variable analysis were used to identify potential risk factors for retinal re-detachment.
Results
Median follow-up was 6.2 months. 17/203 eyes (8.4%) in the 360° ILR group had retinal re-detachment after primary PPV, which was significantly lower compared to the focal laser retinopexy group (19/141 eyes, 13.5%) (p < 0.05). In multivariate Cox regression, the risk factors for retinal re-detachment were without additional 360° ILR, diabetes and macula off before the primary surgery (relatively OR = 0.456, 95%-CI [0.245–0.848], p < 0.05; OR = 2.301, 95% CI [1.130–4.687], p < 0.05; OR = 2.243, 95% CI [1.212–4.149], p < 0.05).
Conclusions
Additional 360° ILR group had a significantly lower rate of retinal re-detachment when compared with focal laser retinopexy group. Our study also elucidated that diabetes and macular off before the primary surgery might also be the potential risk factors for higher rate of retinal re-detachment outcome.
Trial registration:
This was a retrospective cohort study.
Dynamic behaviours of monodisperse double emulsion formation in a tri-axial capillary device
Authors: Dai Yuchen , Cha Haotian , Nguyen Nhat-Khuong , Ouyang Lingxi , Galogahi Fariba , Yadav Ajeet Singh , An Hongjie , Zhang Jun , Ooi Chin Hong , Nguyen Nam-Trung 
Published: September 2022

Abstract

We investigated experimentally, analytically and numerically the formation process of double emulsion formations under dripping regime in a tri-axial co-flow capillary device. The results show that mismatches of core and shell droplets under a given flow condition can be captured both experimentally and numerically. We propose a semi-analytical model using the match ratio between the pinch-off length of the shell droplet and the product of the core growth rate and its pinch-off time. The mismatch issue can be avoided if the match ratio is lower than unity. We considered a model with the wall effect to predict the size of the matched double emulsion. The model shows slight deviations with experimental data if the Reynolds number of continuous phase is lower than 0.06, but asymptotically approaches to good agreement if the Reynolds number increases from 0.06 to 0.14. The numerical simulation generally agrees with the experiments under various flow conditions.