bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intubation-related airway injury leads to surgery site infection after single-door laminoplasty：a case report and literature review
Authors: Yi Meng , Song Jipeng , Zhang Yao , Fan Yuyu , Ding Lixiang 
Published: November 2022

Abstract
Background: Open-door laminoplasty is an effective surgical method for treating cervical spondylotic myelopathy. There are many risk factors associated with infection at the surgical site after cervical spine surgery, but few cases have been reported of infection at the surgical site due to tracheal injury.
Case presentation: Herein, we report a case of a 56-year-old man with partial paralysis due to acute cervical spinal cord compression. The drainage bag is always filled with gas after cervical laminoplasty. After examination, it was considered that the trachea was damaged by endotracheal intubation, which resulted in gas escaping from loose tissue. The wound healing was poor after surgery. We performed two debridements and two months of antibiotic therapy. Finally, we retained the patient's cervical internal fixation device and the patient's symptoms of incomplete paralysis were significantly improved.
Conclusions: Abnormal drainage bag may be an early indication of possible trachea injury. We can avoid possible adverse consequences by early recognition.
Cross Sectional Study on Sleep Disorders for Autistic Children in Anhui Province of China
Authors: Zhang Nuo-chen , Liu Zhi-cheng , Qu Ai-na , Wang Lu-lu , Liu Jun , Gao Hui , Lv Fu-li , Sun Jing-min , Wu De 
Published: November 2022

Abstract
Objectives
Sleep disorder is an important adverse factor affecting the prognosis of children with autism. This study focuses on the condition of sleep problems in children with autism spectrum disorder and its association to severity.
Participants and methods:
The Anhui disabled people' Federation has listed 153 autism training facilities. Half of them (5508 kids) are chosen using odd and even codes between the ages of 1 and 8 years. 1377 autistic kids in total were chosen at random for the questionnaire survey using a 1:4 (numerical code). The Children's Sleep Habit Questionnaire (CSHQ), the Childhood Autism Rating Scale (CARS) and the Autism Behavior Checklist (ABC) were looked into and assessed, respectively.
Results
A total of 1072 valid questionnaires were received, including 818 boys and 254 girls, with a male to female ratio of 3.22:1. A total of 98.60% of the kids, 568 kids (98.1%) in the mild to moderate ASD group, and 489 kids (99.18%) in the severe ASD group, reported having sleep issues. The overall mean CSHQ score for the entire sample was 51.57±7.16, with the severe group reporting higher scores than the mild to moderate group (51.58±8.05 vs 49.52±7.69, p<0.001). Similarly, subscales of CSHQ such as sleep on set delay (7.80 ± 1.61 vs 7.58 ± 1.52, p = 0.027), sleep resistance (3.69 ± 1.12 vs 3.40 ± 1.15, p < 0.001), sleep duration (6.27 ± 1.25 vs 6.03 ± 1.08, p = 0.001), sleep anxiety (4.21 ± 1.54 vs 3.99 ± 1.52, p = 0.019) and night waking (5.33 ± 1.82 vs 4.85 ± 1.55, p < 0.001) were more problematic among severe group compared to mild to moderate group. According to regression research, the type of caregiver and their educational background have an impact on the severity of sleep disturbances. Sleep difficulties are always negatively correlated with nurturing environment, whereas wake-up times are the contrary.
Conclusions
The high likelihood of sleep disturbances in Chinese ASD children calls for the urgent adoption of parental education and social support programs to lessen the effects of sleep issues in ASD families. Important risk variables that affect sleep disorders and the severity of autism include wake-up time, caregiver, and nurturing environment. ASD children's sleep quality may be dramatically improved by encouraging fathers to participate in sleep instruction, creating a healthy nurturing environment, and cutting back on wake-up time.
Fixed points of (α,β,F∗) and (α,β,F∗∗)-weak Geraghty contractions with an application
Authors: Alam Khairul Habib , Rohen Yumnam 
Published: November 2022

Abstract
This study aims to provide new classes of (α,β,F∗)-weak Geraghty contraction and (α,β,F∗∗)-weak Geraghty contraction, a self generalized contractions on any metric space. Further we find that the mappings satisfying the definition of such contractions have unique fixed point if the base space is complete. Also there is an application for existing unique solution of two-point boundary value problem.
Interleukin 6 and Interferon gamma haplotypes are related to cytokine serum levels in dogs in an endemic Leishmania infantum region
Authors: Álvarez Luis , Marín-García Pablo-Jesús , Rentero-Garrido Pilar , Llobat Lola 
Published: November 2022

Abstract
Background: The Ibizan Hound is a canine breed native to the Mediterranean region, where leishmaniasis is an endemic zoonosis. Several studies indicate a low prevalence of this disease in Ibizan hound dogs, whereas other canine breeds present a high prevalence. However, the molecular underlaying mechanisms yet remains unknown.
Methods: In this study, we analyze the haplotypes of genes encode cytokines related to immune response of Leishmania infantum infection in twenty-four Boxer and twentyfour Ibizan hound apparently healthy using CanineHD DNA Analysis BeadChip including 165,480 mapped positions.
Results: The results show that haplotypes of genes encoding Interleukin 6 (IL6) and Interferon gamma (IFNG) are related to Interferon gamma (IFN-γ), and Interleukins (IL) 2 and 18 serum levels. Our results indicate that the regulation of immune response is different in the two canine breeds analyzed and are related to the haplotype compositions of the genes encoding these cytokines.
Conclusions: Haplotypes in the IFNG and IL6 genes have been correlated to serum levels of IFN-γ, IL-2 and IL-18, and moderate effect on IL8 haplotype correlated to IL-8 and IL-18 serum levels has been found. The results indicate that the resistance to L. infantum infection could be a consequence of certain haplotypes with a high frequency in the Ibizan Hound dog breed, while susceptibility to the disease would be related to other specific haplotypes, with high frequency in Boxer. Future studies are needed to elucidate whether these differences and haplotypes are related to different phenotypes in immune response and expression gene regulation to L. infantum infections in dogs and its possible application of new treatments and vaccines.
Unusual findings in 68 cases of appendiceal diverticulum: Accompanying neoplastic lesion should be kept in mind
Authors: Ekinci Nese , Gun Eylul 
Published: November 2022

AbstractPurpose:Congenital and acquired diverticula of the appendix are very rare and may be associated with a variety of lesions. In this study, we aimed to evaluate the cases of the appendiceal diverticulum (AD) in terms of histopathological features and accompanying neoplastic and non-neoplastic lesions.Methods:A retrospective analysis of the appendectomy specimens between January 2007 and June 2022 was performed. All of the cases with AD were reviewed and slides of all cases were re-examined by two pathologists, one of whom was highly experienced in gastrointestinal pathology. The cases were evaluated in terms of age, gender, histopathological features, accompanying neoplastic and non-neoplastic lesions, presence of periappendicular mucin, and misdiagnosis.Results:There were a total of 68 AD cases with 32 (47%) males and 36 (53%) females. The mean age was 54,1 years (24-93). Diverticulitis was seen in 44 cases (64,7%). In 28 (41,1%) cases ADs were accompanied by other lesions such as low-grade appendiceal mucinous neoplasm (LAMN, n=13), endometriosis (n=4), well-differentiated neuroendocrine tumor (n=3), sessile serrated adenoma (SSA, n=3), adenocarcinoma (n=2), LAMN and WD-NET (n=1), granular cell tumor (n=1), and hyperplastic polyp with inflammatory fibroid polyp (n=1). Periappendiceal acellular mucin deposition was seen in 23 (33,8%) cases with associated diverticulitis in 12 of them. In 7 of the 13 cases of LAMN there was mucin accumulation. AD was incidentally found in 15 appendectomies performed during other surgeries. Although defined macroscopically in 8 cases, the diagnosis of AD was missed during the microscopical examination.Conclusion:The probability of detecting a neoplastic lesion in cases with AD is quite high as proven in our study. Therefore, the entire appendix can be sampled in these cases. It is important to pay attention to macroscopic definitions in order not to miss a possible diverticulum in all cases with microscopic perforation and dense inflammation. The close association between LAMN and AD should be kept in mind.
Rapacaspase-9-based Suicide Gene Applied to the Safety of Il-1rap Car-t Cells
Authors: BOUQUET Lucie , WARDA Walid , ROCHA Mathieu NETO DA , TRAD Rim , NICOD Clémentine , HADERBACHE Rafik , GENIN Delphine , FERRAND Christophe , Deschamps Marina 
Published: November 2022

Abstract
Even if adoptive cell transfer (ACT) has already shown great clinical efficiency in different types of disease, such as cancer, some adverse events consistently occur, and suicide genes are an interesting system to manage these events. Our team developed a new medical drug candidate, a chimeric antigen receptor (CAR) targeting interleukin-1 receptor accessory protein (IL-1RAP), which needs to be evaluated in clinical trials with a clinically applicable suicide gene system. To prevent side effects and ensure the safety of our candidate, we devised two constructs carrying an inducible suicide gene, RapaCasp9-G or RapaCasp9-A, containing a single-nucleotide polymorphism (rs1052576) affecting the efficiency of endogenous caspase 9. These suicide genes are activated by rapamycin and based on the fusion of human caspase 9 with a modified human FK-binding protein, allowing conditional dimerization. RapaCasp9-G- and RapaCasp9-A-expressing gene-modified T cells (GMTCs) were produced from HDs (HDs) and acute myeloid leukemia (AML) donors. The RapaCasp9-G suicide gene demonstrated better efficiency, and we showed its in vitro functionality in different clinically relevant culture conditions. Moreover, as rapamycin is not pharmacologically inert, we also demonstrated its safe use as part of our therapy.
Morphometric study of the ossification centers of the presphenoid and basisphenoid parts of the sphenoid body in the human fetus
Authors: Grzonkowska Magdalena , Szpinda Michał , Badura Mateusz , Wiśniewski Marcin , Biernacki Maciej , Baumgart Mariusz 
Published: November 2022

Abstract
Purposes Understanding the growth and development of the sphenoid bone is crucial in assessing the normal and pathological development of the cranium. The aim of the present study was to examine the growth dynamics of the primary ossification centers of the sphenoid body in the human fetus, based on their linear, planar and volumetric parameters.
Material and Methods The examinations were carried out on 37 human fetuses of both sexes (16 males and 21 females) aged 18–30 weeks of gestation, which were preserved in 10% neutral formalin solution. Using CT, digital image analysis software, 3D reconstruction and statistical methods, we evaluated the size of the primary ossification centers of the sphenoid bone.
Results The morphometric characteristics of the primary ossification centers of the presphenoid and basisphenoid of the sphenoid body display no sex differences. These ossification centers grow linearly with respect to their sagittal diameter, projection surface area and volume for the presphenoid part and with respect to volume for the basisphenoid part, and logarithmically regarding the transverse diameter for the presphenoid part, as well as the sagittal and transverse diameters and projection surface area for the basisphenoid part.
Conclusions The numerical findings associated with the primary ossification centers of the sphenoid body may be considered as age-related normative data of clinical relevance in the estimation of gestational ages and the diagnostics of congenital defects.
Seismic Damage Classification for Axially-Loaded Reinforced Concrete Frame Members based on Compressive Strain
Authors: Shiradhonkar Saurabh R. , Sinha Ravi 
Published: November 2022

Abstract
Quantification of seismic damage to reinforced concrete (RC) members in terms of damages states is important for condition assessment and performance-based seismic design. This paper presents a classification for axially-loaded flexural-dominant RC members into clearly-differentiated damage states based on change in failure mode, principles of mechanics, and loss in lateral load capacity. The paper considers extreme fiber compressive strain as the Engineering Response Parameter (ERP) for classification of the damage states. The identification of member damage states based on compressive strain can be very useful for seismic assessment of the existing buildings and performance-based design of new buildings. Published experimentally-observed cyclic force-displacement relationships of RC columns have been numerically simulated and are used to develop statistics of compressive strain. These are further used to develop semi-empirical expressions for extreme fiber compressive strain in terms of RC member properties, viz. axial load ratio, longitudinal reinforcement ratio, and confinement reinforcement ratio. It is shown that the proposed expressions accurately predict experimentally observed compressive strain at different damage states. The fragility functions of damage states, that provide the probability of occurrence of the strain limits, are also presented. It is seen that the proposed expressions for strain and their limits accurately identify the damage states on the monotonic stress-strain relationship of confined concrete and validate the use of strain as an ERP. The present study also provides strain limits for different damage states with consistent level of conservatism.
Crustal structure and geothermal mechanism of Gonghe-Guide Basin based on EIGEN-6C4 satellite gravity and aeromagnetic data
Authors: Zhou Wenna , Li Qiang , Zhang Dailei , Tang Hai 
Published: November 2022

Abstract
Gonghe-Guide Basin is situated in the northeastern edge of the Tibetan Plateau. one of China's main targets for geothermal research and exploitation. It is also a crucial region for studying the Tibetan Plateau's uplift mechanisms. Therefore, the elaborate crustal structure of the entire basin is essential for recognizing the geothermal mechanisms, geothermal source targets and even the uplift mechanisms of the Tibetan Plateau. However, these issues remain enigmatic, partly because it is difficult to depict the crustal structure of entire base by using the profile results of magnetotelluric and seismic data. To overcome the limitations of profile results, we present a new crustal structure of the entire Gonghe-Guide Basin by using EIGEN-6C4 satellite gravity and aeromagnetic data. The gravity and magnetic data were processed using the wavelet multi-scale decomposition method and the iterative compact depth from extreme points imaging method. Satisfactory residual anomalies and inversion results were obtained. The gravity inversion results reveal pronounced low-density regions at the depths of 15–35 km in the middle-upper crustal, most likely caused by partial melting from heating the overlying hot dry rocks. The results correspond well with the magnetotelluric and seismic results and are an effective supplement. The magnetic inversion results show negative or no magnetism within a similar depth range. But at shallow depths of the same horizontal positions, there is high positive magnetism, which can be interpreted as granite. To confirm and validate this conclusion, a 2D geologic model of a profile from a typical area is created to show the detailed tectonic. Based on the new crustal structure results, the suggested geothermal target is the low/negative density corresponding to low/negative magnetism located at deep depths and high/ positive magnetism located at shallow depths. These density and magnetism anomalies are primarily located near the town of Guide, Gonghe, Xinjie, Chaka, Wayuxiangka, Tanggemu, Xinhai, which can be considered geothermal source targets. The geothermal source is thought to be due to mantle material upwelling or faults activity causing partial melting in the crust, and heat flows from deep to shallow along the faults in the region. Then we established a geological conceptual model to illustrate this process. This indicates that tectonic movement is taking place in the deep part of the earth in Gonghe-Guide Basin. The research on the geological structure and geothermal heat source mechanism in the Gonghe-Guide Basin can provide a primary reference for research on geothermal resources in other areas with similar geological structures.
Prescribing errors in children: What is the impact of a computerized physician order entry?
Authors: Satir Aylin N. , Pfiffner Miriam , Meier Christoph R. , Good Angela Caduff 
Published: November 2022

Abstract

Purpose: Prescribing errors represent a safety risk for hospitalized patients, especially in pediatrics. Computerized physician order entry (CPOE) might reduce prescribing errors, although its effect has not yet been thoroughly studied on pediatric general wards. This study investigated the impact of a CPOE on prescribing errors in children on general wards at the University Children’s Hospital Zurich.
Methods: We performed medication review on a total of 1000 patients before and after the implementation of a CPOE. The CPOE included limited clinical decision support (CDS) such as drug-drug interaction check and checks for duplicates. Prescribing errors, their type according to the PCNE classification, their severity (adapted NCC MERP index) as well as the interrater reliability (Cohen’s Kappa) were analyzed.
Results: CPOE significantly reduced the rate of errors from 25 errors / 100 prescriptions (95% CI: 23 – 27) to 16 errors / 100 prescriptions (95% CI 14 – 18). Particularly the prescribing quality was improved by reducing PCNE error 5.2 “lacking information” (e.g. lacking drug form or maximum possible number of doses for reserve medication). Medication reconciliation problems (PCNE error 8), such as drugs prescribed on paper as well as electronically, significantly increased after introduction of the CPOE. The most common pediatric prescribing errors, the dosing errors (PCNE errors 3), were not statistically significantly altered after introduction of the CPOE. Overall severity of errors was reduced. Interrater reliability showed moderate agreement (Κ = 0.48).
Conclusions: The CPOE increases patient safety by reducing the rate and severity of prescribing errors. The reason for the observed increase in medication reconciliation problems might be the hybrid-system with remaining paper-prescriptions for special medication. The lacking effect on dosing errors might be explained by the fact that a web application CDS covering dosing recommendations (PEDeDose) was already in use before implementation of the CPOE. Further investigations should focus on eliminating hybrid systems, interventions on how to increase the usability of the CPOE, and full integration of CDS tools such as automated dose check into the CPOE.
Sexual violence and associated factors among women of reproductive age in Rwanda: a nationwide cross-sectional survey
Authors: Nuwabaine Lilian , Kawuki Joseph , Amwiine Earnest , Asiimwe John Baptist , Sserwanja Quraish , Gatasi Ghislaine , Donkor Elorm , Atwijukiire Humphrey 
Published: November 2022

Abstract
Background
Sexual violence against women is a global public health issue with both short and long-term effects on the physical and mental health of women. This study aimed to determine the prevalence of sexual violence and its associated factors among women of reproductive age in Rwanda.
Methods
We used secondary data from the 2020 Rwanda Demographic and Health Survey of 1,700 participants, who were selected using multistage stratified sampling. Multivariable logistic regression was conducted to explore factors associated with sexual violence, using SPSS (version 25).
Results
Of the 1,700 women of reproductive age, 12.4% (95%CI: 11.0-14.1) had experienced sexual violence. Justified beating (AOR = 1.34, 95%CI: 1.16–1.65), not having health insurance (AOR = 1.46, 95%CI: 1.26–2.40), not being involved in healthcare decision-making (AOR = 1.64, 95%CI: 1.99–2.70), having a husband/partner with primary (AOR = 1.70, 95%CI: 5.47–6.21) or no education (AOR = 1.84, 95%CI: 1.21–3.37), as well as having a husband/partner who sometimes (AOR = 3.37, 95%CI: 1.56–7.30) or often (AOR = 12.87, 95%CI: 5.64–29.38) gets drunk were positively associated with sexual violence. However, women from male-headed households (AOR = 0.52, 95%CI: 0.29–0.92) were less likely to experience sexual violence.
Conclusions
There is a need to demystify negative culturally-rooted beliefs favouring sexual violence such as justified beating as well as increasing efforts to promote women's empowerment and healthcare access. Moreover, engaging men in anti-sexual violence strategies is paramount in addressing male-related issues that expose women to sexual violence.
Effect of antimicrobial therapy on progression free survival of immunotherapy and chemo-/immunotherapy in patients with non-small cell lung cancer
Authors: Uhlenbruch Mark , Krüger Stefan 
Published: November 2022

Abstract
Background: The choice between immunotherapy with a checkpoint inhibitor (CPI) and chemo-/immunotherapy (CIT) in patients with NSCLC stage IV is often discussed. There is some data that the effect of CPI-therapy is impaired by antimicrobial therapy (AMT). Little is known about the influence of AMT on CIT.
Patients and methods: We retrospectively analysed 114 patients (age 68 ± 8.5 y) with NSCLC stage IV. Patients were treated according to the guidelines with either CPI alone (pembrolizumab, nivolumab, atezolizumab, cemiplimab) or CIT (Carboplatin/Pemetrexed/Pembrolizumab, Carboplatin/Paclitaxel/Pembrolizumab). We registered patients’ characteristics including presence and timing of AMT. Group 1 consisted of 42 patients with AMT in the month before CPI or CIT, group 2 were 49 patients with AMT during CPI or CIT, and group 3 were 64 patients without AMT and CPI or CIT.
Results: Group 1-3 showed comparable patients characteristics. Using cox-regression analysis, we found that AMT in the month before CPI resulted in a decreased progression free survival (PFS) compared to patients with CPI and no AMT (14 ± 1.02 vs. 4 ± 1.02 months, p = 0.002, 95% CI: 1.88-9). In patients, who were treated with CIT, there was no difference in PFS in those with or without AMT in the month before therapy (10 ± 2.5 vs. 6 ± 1.2 months, p = 0.7). Interestingly, AMT during CIT or CPI therapy showed no effect on PFS.
Conclusions: In a real-life setting, we found that AMT reduces PFS when given in the month before CIT therapy. AMT before or during CIT does not seem to influence PFS. As a consequence, AMT before start of therapy might be a factor that could lead to a preference of CIT instead of CPI in NSCLC stage IV patients