bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early bone formation around immediately placed two-piece tissue-level zirconia implants with a modified surface: an experimental study in the miniature pig mandible
Authors: Glauser Roland , Schupbach Peter 
Published: September 2022

Abstract
Purpose
To histologically examine early bone formation around transmucosal implants and to evaluate the influence of surface characteristics on early peri-implant bone healing using a miniature pig model. For this, commercially available dental implants with a rough zirconia (YTZP) surface were compared to surface-modified Ti control implants at 4 and 8 weeks after placement.

Methods
Immediately following the extraction of six mandibular premolars, 20 two-piece, tissue-level, screw-shaped YTZP implants (Patent™ Standard Zirconia Implant ø4.1 × 11 mm) with a modified rough blasted before sintering surface were inserted in four adult miniature pigs. In addition, four titanium (Ti) tissue-level implants (Straumann® Standard RN ø4.1 × 10 mm Roxolid®) with a moderate surface (SLActive®), one per animal, were placed as control implants. A histological analysis was performed on the hard tissues after 4 and 8 weeks of transmucosal healing.

Results
The results show a high rate of osseointegration of the test YTZP dental implants at 4 and 8 weeks following insertion. At 4 weeks, a bone-to-implant contact ratio (BIC) of 73.7% (SD ± 16.8) for the test implants (n = 10) and 58.5% for the first control implant was achieved. The second control implant had to be excluded from analysis. At 8 weeks, a BIC of 82.4% (SD ± 16.9) for the test implants (n = 9) and 93.6% (SD ± 9.1) (n = 2) for the control implant was achieved. No statistical difference was observed comparing 4 and 8 weeks YTZP data (p = 0.126).

Conclusions
The results indicate a predictable osseointegration of immediate zirconia implants with a modified YTZP implant surface and a high degree of BIC present at 4 weeks following insertion. After 8 weeks of healing both the zirconia implants and the Ti implants show a BIC indicating full osseointegration. Further studies involving a larger sample size with more time points are needed to confirm these results.
Number sense: the mediating effect between nonverbal intelligence and children’s mathematical performance
Authors: Zhou Hui , Tan Qiutong , Ye Xiaolin , Miao Lujia 
Published: September 2022

AbstractThe study explored the mediating effect of number sense between nonverbal intelligence and children’s mathematical performance. The sample consisted of 131 pupils in Shaoxing City of China from grades 1, 3, and 5. The students completed measures of nonverbal intelligence, number sense, basic arithmetic ability, mathematical performance, rapid automatized naming, and working memory. Results show that although all variables significantly relate with each other (all p < .01), only nonverbal intelligence, number sense, and basic arithmetic ability significantly affect children’s mathematical performance (all p < .01). According to multiple-mediation model, nonverbal intelligence significantly predicts children’s mathematical performance through number sense and basic arithmetic ability. These findings suggest that domain-specific mathematical skills play a prominent role in children’s mathematical performance in primary school, rather than domain-general cognitive functions. Educators should pay attention to develop children’s number sense in order to improve children’s mathematical ability.
Biocidal potential of indigenous isolates of Entomopathogenic Nematodes (EPNs) against tobacco cutworm, Spodoptera litura Fabricius (Lepidoptera: Noctuidae)
Authors: Tomar Preety , Thakur Neelam 
Published: September 2022

Abstract
Background
Entomopathogenic nematodes (EPNs) have been regarded as the most convenient strategy for insect pest management. The native strains of EPNs: Heterorhabditis bacteriophora EUPT-SD, H. bacteriophora EUPT-R, H. bacteriophora EUPT-KN, H. bacteriophora EUPT-K and H. bacteriophora EUPT-H isolated from mid-Himalayan region of Himachal Pradesh were tested in laboratory for their multiplication and virulence against 3rd and 4th larval instars of the tobacco cutworm, Spodoptera litura Fabricius (Lepidoptera: Noctuidae), the serious polyphagous pest affecting a wide range of agricultural crops worldwide.

Results
All the EPN strains were effective against 3rd and 4th larval instars of S. litura. Insect mortality reached 90–96% after 96 h at nematode concentrations of 150 infective juveniles (IJs)/ml. The insect mortality was also recorded at low concentrations of IJs, but the most exposure period was required. High virulence was shown by H. bacteriophora EUPT-SD 96 and 94%, followed by H. bacteriophora EUPT-R 92 and 90%, H. bacteriophora EUPT-KN 92 and 90%, H. bacteriophora EUPT-K 92 and 90% and H. bacteriophora EUPT-H 92 and 90%, respectively, against 3rd and 4th larval instars in terms of reproductive potential and killing. All the insects were alive in the absolute control.

Conclusion
Utilization of EPNs for the management of S. litura may be the best method to overcome the insect resistance problems and to manage the population of this insect pest. It may be an effective method and may be a partial substitute of synthetic insecticides, thus minimizing the excessive use of synthetic chemicals. The results demonstrated the potential of indigenous EPNs isolates against S. litura, but before further recommendation, multiplication field trials need to be conducted to confirm their efficacy at farm level.
Systematic Review of Traumatic Thoracic Spondyloptosis and Presentation of a Novel Approach for Management With Quad Rod Construct
Authors: Anokwute Miracle C. , House Hanna , Huh Andrew , Ordaz Josue , McVeigh Luke , Stockwell David W. 
Published: September 2022

BACKGROUND:
Traumatic thoracic spondyloptosis (TTS) is a rare but devastating spinal injury often secondary to high-impact trauma. TTS is typically managed with surgical fusion and stabilization.

OBJECTIVE:
To evaluate current surgical management of TTS while presenting a novel surgical technique for reduction and fusion.

METHODS:
We performed a systematic review of surgical management of TTS using Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Individual Participant Data guidelines with 2 independent reviewers. We identified patient demographics, level of spondyloptosis, American Spinal Injury Association grade, level of spinal fusion, surgical approach, type of construct used, and reduction of fracture.

RESULTS:
Seventeen articles with 37 patients with TTS managed surgically were identified. The male:female ratio was 31:6. The average age was 33 years (±15). Motorized injury including motor vehicle accident, road traffic accident, and motor vehicle collision (16 patients, 43%) and fall including fall from height, stairs, train, or standing (16 patients, 43%) were equivalent. The middle (15 patients 40%) and lower (18 patients, 49%) thoracic regions were similar for the level of spondyloptosis. Thirty-four patients (92%) were American Spinal Injury Association A. Thirty-six patients (97.3%) underwent posterior only surgery and 1 (2.7%) underwent a combined posterior–anterior approach. There were 29 (78%) dual rod constructs and 8 (22%) dual rod with connectors or crosslinks. Complete reduction was obtained in 24 (65%) patients, incomplete in 11 (30%), and 2 (5%) patients were not reported. Two of our patients underwent novel quad rod reconstruction with complete reduction.

CONCLUSION:
Surgical management of TTS is typically posterior only with complete fracture reduction. We have presented a novel quad rod approach for reduction of TTS.
Middle Fossa Approach for Resection of a Petrous Apex Cholesterol Granuloma: 2-Dimensional Operative Video
Authors: Weisskopf Peter A. , Turcotte Evelyn L. , Rahme Rudy J. , Bendok Bernard R. 
Published: September 2022

Cholesterol granulomas (CGs) are the most common cyst of the petrous apex.
1
The management options for CG include observation and surgical resection. Surgery is complicated by the proximity of these lesions to critical neurological and vascular structures, as with many skull base lesions; however, if left untreated, their growth may lead to mass effect resulting in conductive hearing loss, cranial nerve dysfunction, tinnitus, and/or chronic headaches.
2,3

In this video, we present the case of 52-year-old woman who presented with medically refractory right retro-orbital headaches. MRI revealed a large, right-sided petrous apex cystic structure consistent with a CG. Computed tomography of the head demonstrated bony remodeling. Given the large size of the cyst and the patient's symptoms, surgery was proposed, and the patient agreed. We performed a middle fossa craniotomy and elevated the dura from the floor of the middle fossa, working posteriorly from the petrous ridge and extending anteriorly. The cyst was exposed and decompressed, and its wall was then dissected off. After all cystic components were removed, the cavity was packed with abdominal fat, which is believed to prevent cyst reaccumulation. Postoperative MRI demonstrated good resection, and the patient reported complete resolution of her headaches.
The patient consented to the procedure as shown in this operative video and gave informed written consent for use of her images in publication.
Regulation of Archease by the mTOR-vATPase axis
Authors: Francis Deanne , Burguete Alondra S. , Ghabrial Amin S. 
Published: September 2022

ABSTRACT
Larval terminal cells of the Drosophila tracheal system generate extensive branched tubes, requiring a huge increase in apical membrane. We discovered that terminal cells compromised for apical membrane expansion – mTOR-vATPase axis and apical polarity mutants – were invaded by the neighboring stalk cell. The invading cell grows and branches, replacing the original single intercellular junction between stalk and terminal cell with multiple intercellular junctions. Here, we characterize disjointed, a mutation in the same phenotypic class. We find that disjointed encodes Drosophila Archease, which is required for the RNA ligase (RtcB) function that is essential for tRNA maturation and for endoplasmic reticulum stress-regulated nonconventional splicing of Xbp1 mRNA. We show that the steady-state subcellular localization of Archease is principally nuclear and dependent upon TOR-vATPase activity. In tracheal cells mutant for Rheb or vATPase loci, Archease localization shifted dramatically from nucleus to cytoplasm. Further, we found that blocking tRNA maturation by knockdown of tRNAseZ also induced compensatory branching. Taken together, these data suggest that the TOR-vATPase axis promotes apical membrane growth in part through nuclear localization of Archease, where Archease is required for tRNA maturation.
Quality assessment of systematic literature on uterine fibroids: a systematic review
Authors: Okesola Mary , Okesola Julius , Ogunlana Olubanke , Afolabi Israel 
Published: September 2022

Background: A systematic literature review (SLR) is a research methodology that examines data and findings of other authors relative to specified research questions (RQ), collects multiple research studies, and summarises them to answer a research question using rigorous methods. Many SLRs have been published on uterine fibroids (UFs) in the last two decades but there is a dearth of knowledge on assessment of the quality to determine the reliability of results. Methods: This study employed the SLR method to identify available SLRs published on UFs. Dybå and Dingsøyr quality standards and dichotomous grading scales were employed to determine the quality of primary studies. On February 3rd, 2022, an auto search was conducted twice over Citeseer, EBSCO, ACM, Springer Link, IEE Computer society digital library, and Scopus using 17 search strings. Two teams independently screened papers and compared notes with the inclusion/exclusion criteria. 11 criterial were adapted to evaluate the quality of the SLR’s. Results: 33 SLRs were subjected to data extraction after inclusion/exclusion criteria. Answers to our primary research question was positive as the aims and contexts of the SLRs are generally clear and the methodologies employed are all inclusive. The research outputs of the primary studies are valid and justifiable as their research statements were clear and findings unambiguous. Although some studies failed some quality criteria, answers to all RQs were affirmative as the percentage scores of the studies on each of the quality conditions is favourably high. Conclusions: The auto search may be incomplete because some qualified SLRs may have been missed as the choice of search strings was limited and may have omitted terminologies. Notwithstanding, with average quality scores of 83% in reporting, 81.2% in rigour, and 79% in credibility, this study concludes that majority of the meta-analysis published so far on UF are valid and reliable.
Noninvasive fungal rhinosinusitis: a case series
Authors: Masmoudi Mohamed , Chelli Jihene , Ben Mabrouk Asma , Chebil Ezer , Thabet Wadii , Hasnaoui Mehdi , Mighri Khalifa 
Published: September 2022

Introduction: Fungal rhinosinusitis (FRS) remains a rare disease. The noninvasive forms are hard to diagnose. The management protocols remain controversial. We aim to describe the clinical, radiological and pathological features of noninvasive FRS and present our management protocol and follow-up results. Patients and methods: This descriptive study was conducted in the ear-nose-throat department of the university hospital, Taher Sfar in Mahdia, Tunisia. All patients who responded to the definition of noninvasive FRS (fungal balls and allergic fungal sinusitis) were included. The study was conducted over a three year period (May 2017 – April 2021). Results: Eleven patients were included in this study: four cases of fungal balls and seven cases of allergic fungal sinusitis. Patients presented with symptoms of chronic recurrent rhinosinusitis with no response to conventional treatments. Computed tomodensitometry scan showed opacification of the paranasal sinuses in all patients. Other signs were heterogeneous opacities, local calcifications and thinning of the bony walls of the sinuses. Histopathological findings were inflammatory polyps in all cases of allergic FRS with the presence of fungal hyphae in 42.8% of the cases. All patients underwent surgery after a median delay of 12 [6–24] months of the symptom’s onset. The used procedures were endoscopic middle meatal antrostomy for all patients, ethmoidectomy (81.8%) and sphenoidotomy (36.4%). None received systemic antifungals or corticosteroids with a favorable outcome in all cases. Conclusion: Symptoms of noninvasive FRS are nonspecific. The scan images contribute to the diagnosis, but the perioperative findings and the histopathological results remain crucial. The management is mainly surgical.
Comprehensive geriatric assessment in the emergency department: A protocol for a prospective cohort study
Authors: O'Shaughnessy Íde , Robinson Katie , O'Connor Margaret , Conneely Mairéad , Steed Fiona , Ryan Damien , Carey Leonora , Shchetkovsky Denys , Shanahan Elaine , Leahy Aoife , Quinn Colin , Sheikhi Ali , Galvin Rose 
Published: September 2022

Background: Comprehensive geriatric assessment (CGA) has been shown to improve outcomes in hospitalised older adults; however, there is currently no compelling evidence to support CGA interventions within the Emergency Department (ED). The aim of this study is to explore the clinical and process outcomes of older adults who receive ED-CGA over a period of six months after their initial ED attendance. Design: Prospective cohort study. Methods: The STrengthening the Reporting of the OBservational studies in Epidemiology (STROBE) standardised reporting guidelines will be adhered to. Older adults aged ≥65 years who score ≥2 on the Identification of Seniors at Risk (ISAR) tool and present to the ED with a medical complaint during the operational hours of the dedicated interdisciplinary team, will be considered eligible for recruitment. Demographic and health assessment information will be obtained at the ED index attendance followed by completion of an interdisciplinary CGA. A dedicated research nurse will complete follow-up telephone interviews with participants at 30 days and six months. The primary outcome will be incidence of hospital admission from the ED index attendance. Secondary outcomes will include functional decline, patient satisfaction with the ED index attendance, unscheduled ED reattendance(s), unscheduled hospital (re)admission(s), nursing home admission(s), healthcare utilisation, and death. Descriptive statistics will be used to profile the characteristics of the study participants and multivariate logistic and linear regression analysis will be used to analyse risk of adverse outcomes. Ethics and dissemination: Ethical approval was granted by the University of Limerick Hospital Group Research Ethics Committee (107/2021). The authors will disseminate study findings through publication in a peer-reviewed journal and presentation at national and international conferences. Patient and public involvement will be sought from a panel of older adults at the Ageing Research Centre in the University of Limerick. Clinicaltrials.gov Identifier: NCT05252182.
2021 Amazon Last Mile Routing Research Challenge: Data Set
Authors: Merchán Daniel , Arora Jatin , Pachon Julian , Konduri Karthik , Winkenbach Matthias , Parks Steven , Noszek Joseph 
Published: September 2022

The 2021 Amazon Last Mile Routing Research Challenge, hosted by Amazon.com’s Last Mile Research team, and scientifically supported by the Massachusetts Institute of Technology’s Center for Transportation and Logistics, prompted participants to leverage real operational data to find new and better ways to solve a real-world routing problem. In this article, we describe the data set released for the research challenge, which includes route-, stop-, and package-level features for 9,184 historical routes performed by Amazon drivers in 2018 in five metropolitan areas in the United States. This real-world data set excludes any personally identifiable information: all route and package identifiers have been randomly regenerated and related location data have been obfuscated to ensure anonymity. Although multiple synthetic benchmark data sets are available in the literature, the data set of the 2021 Amazon Last Mile Routing Research Challenge is the first large and publicly available data set to include instances based on real-world operational routing data. History: This paper has been accepted for the Transportation Science Special Issue on Machine Learning Methods and Applications in Large-Scale Route Planning Problems.
Discovery Shopping eCommerce untuk Meningkatkan Pengalaman Pelanggan pada UMKM Produk Tanaman Herbal, Sayuran, dan Alat Berkebun
Authors: Hendrawan Rully Agus , Nurkasanah Ika , Suryani Erma , ER Mahendrawati , Mudjahidin Mudjahidin , Aristio Andre Parvian 
Published: September 2022

Discovery Shopping eCommerce (DSC) merupakan salah satu pendekatan bisnis digital dengan prinsip dasar menyediakan katalog informasi selengkap-lengkapnya terkait produk bagi konsumen yang harus disusun dalam sebuah sistem user friendly. Pendekatan tersebut saat ini masih belum familiar diimplementasikan pada Usaha Mikro, Kecil, dan Menengah (UMKM), dimana berdasarkan CNBC Indonesia tahun 2020, hanya 13% dari 64,2 juta UMKM di Indonesia yang terdigitalisasi. Oleh karena itu, kegiatan pengabdian masyarakat ini berfokus pada pengembangan website dengan pendekatan DSC untuk meningkatkan pengalaman pelanggan yang memiliki ketertarikan pada produk tanaman herbal, sayuran dan alat berkebun. Website ini akan membantu dalam 1) menginformasikan katalog produk tanaman herbal, sayuran dan alat berkebun terkini, lengkap, dan terstruktur 2) mengedukasi pengguna dalam merawat tanaman dan alat berkebun secara detail, 4) menginspirasi pengguna untuk mengkoleksi tanaman, 5) memasarkan produk UMKM bidang tanaman dan alat berkebun. Kegiatan pengabdian masyarakat ini dijalankan dengan beberapa tahapan yakni 1) penggalian kebutuhan dengan wawancara, 2) penyusunan desain pengalaman pengguna, 3) pengembangan website dan kurasi informasi, 4) publikasi dengan menentukan domain dan hosting, 5) pengujian dan evaluasi. Hasilnya, website DSC telah diluncurkan dan dapat meningkatkan bisnis UMKM melalui peningkatan digitalisasi produk, optimasi branding, dan peningkatan jangkauan konsumen yang lebih luas dari empat mitra kami, yaitu UMKM Produk tanaman herbal, sayuran dan alat berkebun
Comparing acute effects of extra virgin coconut oil and extra virgin olive oil consumption on appetite and food intake in normal-weight and obese male subjects
Authors: Metin Ziya Erokay , Bilgic Pelin , Tengilimoğlu Metin Mercan Merve , Akkoca Muzaffer 
Published: September 2022

Objectives
The aim of this study is to compare acute effects of consuming extra virgin coconut oil (EVCO) as a source of medium chain fatty acids and extra virgin olive oil (EVOO) as a source of long chain fatty acids in normal weight and obese subjects.

Design
Randomised, crossover design.

Participants
Metabolically healthy twenty male subjects (10 normal weight; 10 obese) aged 19–40 years.

Intervention
Subjects consumed breakfast meals containing skimmed milk, fat-free white cheese, bread and EVCO (25 g) or EVOO (25 g).

Outcome measures
Visual analog scale evaluations, resting metabolic rate measurements and selected blood parameters analysis (glucose, triglyceride, insulin and plasma peptide YY) were performed before and after the test breakfast meals. In addition, energy intakes were evaluated by ad libitum lunch meal at 180 min.

Results
Visual analogue scale values of hunger and desire to eat decreased significantly after EVCO consumption than EVOO consumption in normal weight subjects at 180 min. There was an increase trend in plasma PYY at 30 and 180 min after EVCO breakfast compared to EVOO breakfast. Ad libitum energy intakes after EVCO and EVOO consumption in normal weight subjects were 924 ± 302; 845 ± 158 kcal (p = 0.272), respectively whereas in obese subjects were 859 ± 238; 994 ± 265 kcal (p = 0.069) respectively.

Conclusion
The results of this study shows that consumption of EVCO compared to EVOO may have suppressive effect on hunger and desire to eat, may affect postprandial PYY levels differently and have no effect on postprandial energy expenditure.

Trial registration
Clinical Trials NCT04738929.