bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbohydrate prolectin-M, a galectin-3 antagonist, blocks SARS-CoV-2 activity
Authors: Sigamani Alben , Chen-Walden Hana , Pahan Jayeeta , Miller Michelle C. , Mayo Kevin H. , Platt David 
Published: July 2022

The SARS-COV-2 (severe acute respiratory syndrome coronavirus 2) virus binds to human lectins to gain entry into cells to replicate. Blocking the virus’s entry using a complex polysaccharide component of [a (1-6)- D-mannopyranose termed “ProLectin M” has an effect on viral replication as a therapeutic tool and a safe alternative to existing antiviral therapies. Little is known about how galectin-3 inhibits viral entry into cells and its impact on the course of viral infection. Here, we investigated the effect of these non-cytotoxic polysaccharides on Vero cells infected with SARS-CoV-2 and demonstrated a dose-dependent reduction in viral load over a 48-hour viral incubation period. A pilot clinical study in five patients with laboratory-confirmed COVID-19 disease was treated with an oral formulation of ProLectin M, and all patients achieved complete disease remission with zero hospitalization or need for oxygen support. Moreover, the viral load was significantly lowered within 2 days of drug administration. On the viral envelope, glycans often play a crucial role in enabling pathogen transmission and/or entry into susceptible target cells. On the molecular level, our NMR spectroscopic studies show that ProLectin M binds relatively strongly to galectin-3, supporting the idea of an antagonist effect on the lectin.
Impact of percutaneous coronary intervention on critical proximal lesion of left anterior descending artery on left ventricular function by echocardiography and tissue doppler
Authors: Ibrahim Emad Abd Elslam , Ahmed Mohamed Mahmoud , Abd- Elghaffar Mahmoud Ahmed , Tayeb Ahmed El 
Published: July 2022

Introduction: lesions in the proximal segment of the LAD coronary artery present a high-risk lesion, as this important anatomical location of atherosclerotic plaques is associated with increased mortality. Patients with chronic ischemic LV dysfunction but viable myocardium will have better LV geometry after revascularization, which in turn will enhance long-term outcome. Objective: to assess the impact of PCI on critical proximal lesion of LAD artery on LV functions by echocardiography and tissue doppler study. Materials and methods: We included 50 patients older than 18 years old with critical proximal LAD lesion who were undergoing elective PCI in cardiology unit, faculty of medicine, Al-Azhar University, Assiut from April 2021 to November 2021. Results: For E/A ratio, we found that the reduction in this ratio was significantly higher among those with preserved EF compared to others. The increase in IVRT and DT over 1 month period was statistically higher among those with preserved EF when compared with others. For E/A ratio, we found that the reduction in this ratio was significantly higher among those with preserved EF compared to others. Also, we found that average E/′E ratio was significantly reduced among those with preserved EF when compared to others.
Assessment the role of survivin and FOXO1 in patient with acne vulgaris in Babylon City
Authors: Mahmoud Hamza , Juda Thana Mohammed , Salman Zena Saeed 
Published: July 2022

Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production,occurs most prominently at skin sites with a high density of sebaceous glands such as the face,chest, and back. Survivin is an evolutionarily conserved eukaryotic protein that is essential for cell division , can inhibit cell death, Normally it is only expressed in actively proliferating cells. Survivin has been found to be increased in keratinocyte proliferative and inflammatory states, which are deeply involved in the pathogenesis of the acne lesions.Foxo1 is considered to be a representative member of the FoxO family, and has key transcription regulatory activities FoxOs are homeostatic factors in healthy skin and in skin disorders,Foxo1 a master regulatory factor for gluconeogenesis and glycogenolysis, as well as a positive regulator of the expression of insulin, is part of signaling axes related to the control of epidermal morphogenesis and the pathogenesis of acne ,The study was a case –control design which conducted in dermatology Al-Musayyab General Hospital and Al Imam Sadiq Hospital,Murjan Teaching Hospital. with 45 patients with Acne volgaris and 45 healthy controls, the level of serum survivin and Foxo1 were measured using an enzyme-linked immunosorbent assay (ELISA).
Fetal biometry is assessment of fetal growth restriction in Telangana region
Authors: Pulluru Upendhar Reddy , Chelli Sudhakara Babu , MakiReddy Poojitha , Sumathy Govindarajan 
Published: July 2022

Background: Intrauterine increase restriction (IUGR) is most common complication in pregnancy and affects morbidity and mortality in any respect degrees of life. With current Doppler research of the fetal important circulation, inclusive of intracardiac flows and the ductus venosus, higher timing of shipping to decrease morbidity can be possible. Serial ultrasound measurements can offer an inexpensive estimate of fetal gestational age and weight primarily based totally on person and composite fetal biometric measurements. Materials and methods: This study consists of pregnant women who are attending OP /IP in department of OBG, SVS medical college, Mehabubnagar, Telanagana. All the retrospective USG quantitative data was noted in case proforma. Sample size was 100 in our study and was divided into cases and controls. Results: In 2nd trimester FGR parameters like FL (30.32), BPD (41.74), AC (136.34), HC (185.36) , GA (20.22) and EFW (310.04) were less when compared to normal fetus. In 3nd trimester we observed FL (61.44), BPD(79.64), AC(287.54) , HC(314.06) , GA (32.06) and EFW (1695.60) which were less when compared to normal fetus. Conclusion: that all the parameters in FGR from 2nd and 3rd trimester were less when compared to normal.
ANALISIS WAKTU BAKU PROSES PRODUKSI ROTI DENGAN METODE STOPWATCH DI UKM FANDRA BAKERY
Authors: Meri Mufrida , Fandeli Hary , Ramadhani Ratih Zulia 
Published: July 2022

Indonesia has many industries engaged in food and culinary. Among them are small and medium enterprises (SMEs) which are very large and make a large contribution to Indonesian economy. To ensure the sustainability of the industry, there is a standard time for each production process. Standard time is the work of observing and recording the working times of both each element or cycle using the tools that have been provided. UKM Fandra Bakrie is one of the small and medium-sized industries that produce bread in Padang City. It is important to know the standard time of the bread making process so that it becomes a reference for management policies. Time measurement using the stopwatch method by calculating the cycle time of each element of bread making work. Measurement data is tested statistically using uniformity tests and data adequacy tests. Then the calculation of standard time by considering adjustment factors and leeway factors. Standard time is used as the basis in determining the amount of production in a given period and for planning production. Based on the results of the study obtained the total time standard for bread production at UKM Fandra Bakery is 287.99 seconds / unit or 4.8 minutes / unit. Thus UKM Fandra Bakery is able to produce as much as 3,200 Pcs per day.
TANGGUNG JAWAB RUMAH SAKIT ATAS KELALAIAN TENAGA MEDIS DALAM PELAYANAN KESEHATAN
Authors: Harmoni Dewi , Fahmi Fahmi , Yetti Yetti 
Published: July 2022

Abstract: This article aims to find out how the hospitals’s legal responsibility for negligence of medical personnel in health services and the legal responsibility of medical personnel for negligence in hospital health services.Hospital is a health care institution that organizes individual health services in a plenary that provides inpatient, outpatient, and emergency services.Article 46 of the hospital law Number 44 of 2009 concerning hospitals explicitly stipulates that hospitals must be legally responsible for losses caused by health workers in hospitals,namely with the presence of a superior respondeat doctor,the hospital is responsibleresponsibility for the quality of care,and the doctrine of vicarious liability,hospital liability,corporate liability.The provisions regarding this responsibility must realy on articles 1367 of the civil code.medical personnel as one of the parties to the agreement by the hospital do have achievement in seeking patient healing through the search for the most appropriate therapy and not in promising healing from the patient he only does his best according to the knowledge and experience he has. Keywords: Hospital Responbility, Negligence, Medical Personnel Abstrak: Artikel ini bertujuan untuk mengetahui bagaimana tanggung jawab hukum Rumah Sakit atas kelalaian tenaga medis dalam pelayanan kesehatan dan tanggung jawab hukum tenaga medis aras kelalaian dalam pelayanan kesehatan di rumah sakit.Rumah Sakit adalah institusi pelayanan kesehatan yang menyelenggarakan pelayanan kesehatan perorangan secara paripurna yang menyediakan pelayanan rawat inap,rawat jalan,dan gawat darurat. Pasal 46 Undang-Undang Rumah Sakit Nomor 44 tahun 2009 Tentang Rumah Sakit secara eksplisit mengatur rumah sakit harus bertanggungjawab secara hukum atas semua kerugian yang ditimbulkan oleh tenaga kesehatan dalam rumah sakit yaitu dengan adanya doktrin respondeat superior, rumah sakit bertanggungjawab terhadap kualitas perawatan (duty to care),dan doktrin vicarious liability, hospital liability, corporate liability.Ketentuan mengenai tanggung jawab ini harus bertumpu pada Pasal 1367 KUHPerdata.Tenaga medis sebagai salah satu pihak dalam perjanjian oleh rumah sakit memang memiliki prestasi untuk mengupayakan penyembuhan pasien melalui pencarian terapi yang paling tepat dan bukan pada menjanjikan kesembuhan dari pasien. Oleh karena itu, tenaga medis memiliki tanggungjawab atas tindakan yang dilakukannya hanya sebatas upaya yang terbaik menurut ilmu pengetahuan dan pengalaman yang dimilikinya. Kata kunci: Tanggung Jawab Rumah Sakit, Kelalaian, Tenaga Medis.
PERAMALAN PENJUALAN PARFUM MENGGUNAKAN METODE SINGLE MOVING AVERAGE (SMA) (STUDI KASUS : IM PARFUM PEKANBARU)
Authors: Setiawan Ilfan , Nasution Nurliana 
Published: July 2022

Abstract: Today, there are many perfume distributors in the city of Pekanbaru, one of which is IM Parfum Pekanbaru. Based on sales data from IM Parfum Pekanbaru in October 2021, it is known that perfume sales reached around 1500 bottles. However, in sales they often experience problems, namely a lot of perfume stock that does not meet demand and is not even sold at all, it means that perfume supplies sometimes experience shortages and excesses so that the perfume is returned to the supplier at a loss due to not being sold. Forecasting is an important tool in effective and efficient planning. Forecasting is a prediction, projection or estimation of the level of uncertain events in the future. Based on research conducted at IM Parfum Pekanbaru using a forecasting system with the Single Moving Average method, it can help IM Parfum Pekanbaru store to recap sales data every month where the data is stored in the database. The forecasting system using the Single Moving Average method for forecasting perfume inventories for December 2021 is 1542 bottles with a MAD value of 242, an MSE value of 127073,4 and a MAPE value of 17.3%. Keywords: Forecasting, Single Moving Average, Parfume Sale Abstrak: Dewasa ini, banyak distributor parfum di kota Pekanbaru, salah satunya adalah IM Parfum Pekanbaru. Berdasarkan data penjualan IM Parfum Pekanbaru bulan Oktober 2021 diketahui bahwa penjualan parfum mencapai sekitar 1500 botol. Akan tetapi dalam penjualannya sering mengalami permasalahan yaitu banyak stok parfum yang tidak mencukupi permintaan dan bahkan tidak terjual samasekali, itu artinya persediaan parfum terkadang mengalami kekurangan dan berlebih sehingga parfum tersebut dikembalikan ke pemasok dengan kerugian akibat tidak terjual. Peramalan atau forecasting merupakan alat bantu yang penting dalam perencanaan yang efektif dan efisien. Peramalan adalah prediksi, proyeksi atau estimasi tingkat kejadian yang tidak pasti dimasa yang akan datang. Berdasarkan penelitian yang dilakukan pada IM Parfum Pekanbaru menggunakan sistem peramalan dengan metode Single Moving Average, maka dapat membantu toko IM Parfum Pekanbaru untuk merekap data penjualan setiap bulannya dimana data tersebut disimpan ke database. Sistem peramalan menggunakan metode Single Moving Average pada peramalan persediaan parfum untuk bulan Desember 2021 adalah sebanyak 1542 botol dengan nilai MAD sebesar 242, nilai MSE sebesar 127073,4 dan nilai MAPE sebesar 17,3%. Kata kunci: Peramalan, Single Moving Average, Penjualan Parfum
PENYELESAIAN SENGKETA MEDIS ANTARA DOKTER GIGI DAN PASIEN DI KOTA PEKANBARU BERDASARKAN UNDANG UNDANG NOMOR 29 TAHUN 2004 TENTANG PRAKTEK KEDOKTERAN
Authors: Anesa Risfa , Hasnati Hasnati , Afrita Indra 
Published: July 2022

Abstract: This article aims to find out the problems regarding the resolution of medical disputes between dentists and patients n the city of Pekanbaru based on law number 29 of 2004 concerning medical practice because n medical disputes patients often experience difficulties n realizing their rights. These problems are studied and researched with the Sociological legal research method and using primary and secondary data. The discussion of this thesis harmonizes the laws and regulations with the real situation n society. The patient's weakness factors were also disclosed ncluding psychological factors, educational and economic factors of the patient causing the patient to have difficulty n fighting for their rights n medical disputes. The resolution of medical disputes that are taken through litigation and non-litigation channels are still found to have weaknesses that are not n favor of the patient. Thus, an dea was found through previous discussions and research, that t s necessary to form a special forum for resolving medical disputes that favors patients as consumers of health services. Keywords: medical dispute, dentist Abstrak: Artikel ini bertujuan untuk mengetahui permasalahan mengenai penyelesaian sengketa medis antara dokter gigi dan pasien di kota pekanbaru berdasarkan undang-undang nomor 29 tahun 2004 tentang praktek kedokteran karena dalam sengketa medik pasien sering mengalami kesulitan dalam mewujudkan haknya. Permasalahan tersebut dikaji dan diteliti dengan metode penelitian hukum Sosiologis dan menggunakan data Primer dan sekunder. Pembahasan tesis ini mengharmonisasikan antara peraturan perundang-undangan dengan keadaan nyata di masyarakat. Faktor-faktor kelemahan pasien juga diungkapankan antara lain faktor psikologis, faktor pendidikan dan ekonomi pasien menyebabkan pasien mengalami kesulitan dalam memperjuangkan haknya di sengketa medik. Penyelesaian sengketa medik yang ditempuh melalui jalur litigasi dan non litigasi masih ditemukan kelemahan-kelemahan yang belum berpihak kepada pasien. Dengan demikian ditemukan suatu gagasan melalui pembahasan dan penelitian yang dilakukan sebeleumnya, bahwa perlu dibentuk suatu wadah khusus penyelesaian sengketa medik yang berpihak kepada pasien selaku konsumen pelayanan kesehatan. Kata kunci: sengketa medis, dokter gigi
IMPLEMENTASI RUJUKAN PERAWATAN SALURAN AKAR GIGI KE DOKTER GIGI SPESIALIS PADA RUMAH SAKIT DI PEKANBARU
Authors: Susandy Andreas , Asnawi Eddy , Azmi Bahrun 
Published: July 2022

Abstract: The dentist available at the hospital or FKTL in the city of Pekanbaru is not a dentist who specializes in dental conservation but is a general dentist. There are not several supporting examinations for patient health care needs that hospitals can provide to patients. Where should a general dentist, following the decree of the minister of health Number HK 02.02/MENKES/62/2015, not handle root canal treatment for molar teeth and following the Regulation of the Minister of Health Number 001 of 2012 that second-level referrals must be to a specialist? This type of research is sociological, legal analysis. Based on interviews and direct observation of services, referrals to patients who need a specialist or sub-specialist health services cannot be provided and are available at referral hospitals due to limited facilities, equipment, and human resources or personnel, such as not there are specialist doctors who are more competent to handle patients with cases that require specialist or sub-specialist health services. Keywords: referral, specialist dentist, minister of health regulation. Abstrak: Dokter gigi yang tersedia di rumah sakit atau FKTL di kota Pekanbaru bukan seorang dokter gigi spesialis konservasi gigi melainkan seorang dokter gigi umum. Dimana seharusnya seorang dokter gigi umum sesuai dengan keputusan menteri kesehatan Nomor HK 02.02/MENKES/62/2015 tidak boleh menangani perawatan saluran akar pada gigi molar dan sesuai dengan Peraturan Menteri Kesehatan Nomor 001 tahun 2012 bahwa rujukan tingkat kedua harus ke dokter spesialis. Jenis penelitian ini adalah penelitian hukum sosiologis. Berdasarkan wawancara yang dilakukan dan observasi terhadap pelayanan secara langsung diketahui bahwa rujukan kepada pasien yang membutuhkan pelayanan kesehatan spesialistik atau sub-spesialistik yang tidak dapat diberikan dan tersedia di rumah sakit rujukan disebabkan alasan keterbatasan fasilitas, peralatan dan/atau sumberdaya manusia atau ketenagaan, seperti tidak adanya dokter spesialis yang lebih berkompeten untuk menangani pasien dengan kasus yang membutuhkan pelayanan kesehatan spesialistik atau sub-spesialistik serta tidak terdapat beberapa pemeriksaan penunjang kebutuhan pelayanan kesehatan pasien yang dapat diberikan oleh rumah sakit kepada pasien. Kata kunci: rujukan, dokter gigi spesialis, peraturan menteri kesehatan
PENENTUAN PENERIMA KARTU INDONESIA PINTAR (KIP) TAHUN 2017/2018 DI SMA NEGERI 03 BENGKULU SELATAN MENGGUNAKAN ALGORITMA WEIGHTED PRODUCT
Authors: Rahayu Novi , Syahputra Dedi 
Published: July 2022

Abstract: KIP (Smart Indonesia Card) is financial support from government given to students whose parents are less able to pay for their children's education. This program is a continuation and expansion of the target of Bantuan Siswa Miskin (BSM) program. This study demonstrates the decision making using the weighted product method. This method uses criteria. The criteria used in this application included; Economically disadvantaged, family income, housing information, and other health insurance ownership. Weighted Product algorithm is one of efficient methods because the time required is very short. Keywords: Weighted product algorithm, Bantuan Siswa Miskin (BSM), KIP Abstrak: KIP (Kartu Indonesia Pintar) adalah bantuan berupa uang tunai dari pemerintah yang diberikan kepada peserta didik yang orang tuanya kurang mampu membiayai pendidikannya, sebagai kelanjutan dan perluasan sasaran dari program Bantuan Siswa Miskin (BSM). Pengambilan keputusan dalam metodeWeighted productini yaitu menngunakan kriteria, adapun kriteria yang dipakai dalam aplikasi ini yaitu Tak Mampu secara Ekonomi, Penghasilan keluarga , Keterangan perumahan , dan Memiliki asuransi kesehatan lainnya .algoritmaWeighted Productmerupakan salah satu metode yang lebih efisien karena waktu yang dibutuhkan sangat singkat. Kata kunci: Algoritma Weighted product, Bantuan Siswa Miskin (BSM), KIP
IMPLIKASI PENGEMBANGAN POTENSI DESA WISATA TERHADAP PENINGKATAN EKONOMI MASYARAKAT DESA LAGAN BUNGIN KECAMATAN SEMIDANG LAGAN KABUPATEN BENGKULU TENGAH DI ERA PANDEMI COVID-19
Authors: Murodah Murodah , Charolina Ovita , Marisidi Marisidi 
Published: July 2022

Abstract: One of the nature-based tourism villages in Semidang Lagan District, Central Bengkulu Regency, is Curug Embun Waterfall in Lagan Bungin Village. However, with the Covid-19 pandemic, Indonesia has experienced a slump in almost all industries. Tourism is one of the sectors most affected by the Covid-19 pandemic. The purpose of this study was to review the implications of developing the potential of tourism villages on improving the economy of the Lagan Bungin Village Community, Semidang Lagan District, Central Bengkulu Regency in the Covid-19 pandemic era. This study uses a descriptive method with a qualitative approach to obtain data and information. This researcher analyzed the data obtained from several sources to answer the problems of the Implications of Developing the Potential of Tourism Villages on the Economic Improvement of the Lagan Bungin Village Community, Semidang Lagan District, Central Bengkulu Regency in the Covid-19 Pandemic Era. The results of this study are that initially only waterfalls and land that is still shaved and chaotic, after being developed into a tourist village, the location becomes beautifully arranged so that some people in Lagan Bungin village take the initiative to open businesses around the tourist village of Curug Embun Waterfall, and have implications for improving the economy of the Lagan Bungin village community. Keywords: tourist village, economic improvement, Covid-19 pandemic. Abstrak: Salah satu desa wisata berbasis alam yang ada di Kecamatan Semidang Lagan Kabupaten Bengkulu Tengah yaitu Air Terjun Curug Embun yang ada di Desa Lagan Bungin. Namun adanya pandemic Covid-19, Indonesia mengalami keterpurukan hampir seluruh industri. Pariwisata menjadi salah satu sektor yang terdampak akibat Covid-19. Tujuan dari penelitian ini adalah untuk meninjau Implikasi Pengembangan Potensi Desa Wisata Terhadap Peningkatan Ekonomi Masyarakat Desa Lagan Bungin Kecamatan Semidang Lagan Kabupaten Bengkulu Tengah di Era pandemi Covid-19. Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif untuk mendapatkan data dan informasi. Peneliti ini menganalisis data yang diperoleh dari beberapa sumber untuk menjawab permasalahan dari Implikasi Pengembangan Potensi Desa Wisata Terhadap Peningkatan Ekonomi Masyarakat Desa Lagan Bungin Kecamatan Semidang Lagan Kabupaten Bengkulu Tengah di Era Pandemi Covid-19. Hasil dari penelitian ini yaitu yang semula hanya Air Terjun semata dan lahan yang masih serut dan sembrawut, setelah dikembangkan menjadi desa wisata maka lokasi tersebut menjadi tertata indah sehingga sebagian masyarakat desa Lagan Bungin berinisiatif untuk membuka usaha di sekitar desa wisata Air Terjun Curug Embun, dan memberikan implikasi terhadap peningkatan ekonomi masyarakat desa Lagan Bungin. Kata kunci: desa wisata, peningkatan ekonomi, pandemi Covid-19