bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Reconnection Geometries With Magnetic Nulls: Multispacecraft Observations and Reconstructions
Authors: Guo Ruilong , Pu Zuyin , Wang Xiaogang , Xiao Chijie , He Jiansen 
Published: February 2022

AbstractMagnetic reconnection is universal in various plasma environments like the solar atmosphere, planetary magnetosphere, and laboratory to trigger explosive phenomena. Its nature and magnetic structure in two dimensions (2D) have been abundantly analyzed. The three‐dimensional (3D) characteristics of reconnection are different from 2D, and the mysteries of its 3D geometry are under exploration. A critical character in 3D is the presence of magnetic nulls, which is essential when the magnetic field topology is changing. The four identical spacecraft from the Cluster mission enable several methods for analyzing and visualizing the 3D nature of the magnetic structure. In this paper, we focus on reviewing the magnetic topology of the reconnection geometry containing 3D magnetic null points. Applying the fitting‐reconstruction method to Cluster data, magnetic null pairs or multiple magnetic nulls linked by separators or helically wrapped spines are found in the reconnection diffusion region and turbulent outflow region. The reconstructed magnetic structures show that the 2D features are parts of local approximations of the 3D geometries. The 2D regimes of antiparallel and component reconnection can simultaneously occur in 3D separator reconnection. The flux ropes are formed along the spine line or in a region enclosed by wrapped fan surfaces in the presence of spiral null points.
Constraints on Crustal Structure in the Vicinity of the Adriatic Indenter (European Alps) From Vp and Vp/Vs Local Earthquake Tomography
Authors: Jozi Najafabadi Azam , Haberland Christian , Le Breton Eline , Handy Mark R. , Verwater Vincent F. , Heit Benjamin , Weber Michael ,   the AlpArray and AlpArray SWATH‐D Working Groups
Published: February 2022

AbstractIn this study, 3‐D models of P‐wave velocity (Vp) and P‐wave and S‐wave ratio (Vp/Vs) of the crust and upper mantle in the Eastern and eastern Southern Alps (northern Italy and southern Austria) were calculated using local earthquake tomography (LET). The data set includes high‐quality arrival times from well‐constrained hypocenters observed by the dense, temporary seismic networks of the AlpArray AASN and SWATH‐D. The resolution of the LET was checked by synthetic tests and analysis of the model resolution matrix. The small inter‐station spacing (average of ∼15 km within the SWATH‐D network) allowed us to image crustal structure at unprecedented resolution across a key part of the Alps. The derived P velocity model revealed a highly heterogeneous crustal structure in the target area. One of the main findings is that the lower crust is thickened, forming a bulge at 30–50 km depth just south of and beneath the Periadriatic Fault and the Tauern Window. This indicates that the lower crust decoupled both from its mantle substratum as well as from its upper crust. The Moho, taken to be the iso‐velocity contour of Vp = 7.25 km/s, agrees with the Moho depth from previous studies in the European and Adriatic forelands. It is shallower on the Adriatic side than on the European side. This is interpreted to indicate that the European Plate is subducted beneath the Adriatic Plate in the Eastern and eastern Southern Alps.
Regional Geology of the Hypanis Valles System, Mars
Authors: Adler Jacob B. , Bell James F. , Warner Nicholas H. , Dobrea Eldar Noe , Harrison Tanya N. 
Published: February 2022

AbstractWe present a geomorphic map of the Hypanis Valles watershed and a geomorphic map of the Hypanis deposit region at its terminus. We mapped these two regions at different scales: 1:2,000,000 for the catchment map (−5° to 10°N and 300°–315°E) and 1:500,000 for the Hypanis deposit map (10°–13.0°N and 313°–316.5°E). Our mapping provides new morphologic insights beyond previous efforts which used lower spatial resolution data. We defined units based on morphology, albedo, thermal inertia, elevation, and spectral parameters. We propose that episodic volcanism and aqueous activity filled the Chryse basin from the early Noachian. Hypanis Valles was active during the Noachian, forming the Hypanis terminal deposits in the southern Chryse region. Hundreds of kilometer‐sized mounds and cones stratigraphically post‐date Hypanis fluvial deposition as these features appear to have erupted or effused through all other major map units. We propose sedimentary diapirism or mud volcanism may be responsible for these features, a hypothesis consistent with the compressional wrinkle ridge tectonism in a sedimentary basin. Future work could further investigate the formation of these cones and mounds and better assess their astrobiologic importance.
Machine Learning Emulation of Urban Land Surface Processes
Authors: Meyer David , Grimmond Sue , Dueben Peter , Hogan Robin , van Reeuwijk Maarten 
Published: February 2022

AbstractCan we improve the modeling of urban land surface processes with machine learning (ML)? A prior comparison of urban land surface models (ULSMs) found that no single model is “best” at predicting all common surface fluxes. Here, we develop an urban neural network (UNN) trained on the mean predicted fluxes from 22 ULSMs at one site. The UNN emulates the mean output of ULSMs accurately. When compared to a reference ULSM (Town Energy Balance; TEB), the UNN has greater accuracy relative to flux observations, less computational cost, and requires fewer input parameters. When coupled to the Weather Research Forecasting (WRF) model using TensorFlow bindings, WRF‐UNN is stable and more accurate than the reference WRF‐TEB. Although the application is currently constrained by the training data (1 site), we show a novel approach to improve the modeling of surface fluxes by combining the strengths of several ULSMs into one using ML.
Controls of the Foreland Deformation Pattern in the Orogen‐Foreland Shortening System: Constraints From High‐Resolution Geodynamic Models
Authors: Liu Sibiao , Sobolev Stephan V. , Babeyko Andrey Y. , Pons Michael 
Published: February 2022

AbstractControls on the deformation pattern (shortening mode and tectonic style) of orogenic forelands during lithospheric shortening remain poorly understood. Here, we use high‐resolution 2D thermomechanical models to demonstrate that orogenic crustal thickness and foreland lithospheric thickness significantly control the shortening mode in the foreland. Pure‐shear shortening occurs when the orogenic crust is not thicker than the foreland crust or thick, but the foreland lithosphere is thin (<70–80 km, as in the Puna foreland case). Conversely, simple‐shear shortening, characterized by foreland underthrusting beneath the orogen, arises when the orogenic crust is much thicker. This thickened crust results in high gravitational potential energy in the orogen, which triggers the migration of deformation to the foreland under further shortening. Our models present fully thick‐skinned, fully thin‐skinned, and intermediate tectonic styles in the foreland. The first tectonics forms in a pure‐shear shortening mode whereas the others require a simple‐shear mode and the presence of thick (>∼4 km) sediments that are mechanically weak (friction coefficient <∼0.05) or weakened rapidly during deformation. The formation of fully thin‐skinned tectonics in thick and weak foreland sediments, as in the Subandean Ranges, requires the strength of the orogenic upper lithosphere to be less than one‐third as strong as that of the foreland upper lithosphere. Our models successfully reproduce foreland deformation patterns in the Central and Southern Andes and the Laramide province.
A construction classification system database for understanding resource use in building construction
Authors: Guven Gursans , Arceo Aldrick , Bennett Allison , Tham Melanie , Olanrewaju Bolaji , McGrail Molly , Isin Kaan , Olson Alexander W. , Saxe Shoshanna 
Published: February 2022

AbstractThe building sector is a voracious consumer of primary materials. However, the study of building material use and associated impacts is challenged by the paucity of publicly available data in the field and the heterogeneity of data organization and classification between published studies. This paper makes two main contributions. First, we propose and demonstrate a building material data structure adapted from UniFormat and MasterFormat, two widely used construction classification systems in North America. Second, the dataset included provides fine grained material data for 70 buildings in North America. The dataset was developed by collecting design or construction drawings for the studied buildings and performing material takeoffs based on these drawings. The ontology is based on UniFormat and MasterFormat to facilitate interoperability with existing construction management practices, and to suggest a standardized structure for future material intensity studies. The data structure supports investigation into how form and building design are driving material use, opportunities to reduce construction material consumption and better understanding of how materials are used in buildings.
Systematic review and meta-analysis of cognitive impairment in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Authors: Aoun Sebaiti Mehdi , Hainselin Mathieu , Gounden Yannick , Sirbu Carmen Adella , Sekulic Slobodan , Lorusso Lorenzo , Nacul Luis , Authier François Jérôme 
Published: February 2022

AbstractMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is commonly associated with cognitive complaints. To bring out the neuropsychological symptomatology inherent to ME/CFS, we conducted a systematic review according to PRISMA and MOOSE guidelines of the literature through the analysis of 764 studies published between 1988 and 2019 by using PubMed Central website and Clarivate analytics platform. We performed a meta-analysis to delineate an idea of the neuropsychological profile inherent in ME/CFS. The clinical picture typically affects visuo-spatial immediate memory (g = − 0.55, p = 0.007), reading speed (g = − 0.82, p = 0.0001) and graphics gesture (g = − 0.59, p = 0.0001). Analysis also revealed difficulties in several processes inherent in episodic verbal memory (storage, retrieval, recognition) and visual memory (recovery) and a low efficiency in attentional abilities. Executive functions seemed to be little or not affected and instrumental functions appeared constantly preserved. With regard to the complexity and heterogeneity of the cognitive phenotype, it turns out that determining a sound clinical picture of ME/CFS cognitive profile must go through a neuropsychological examination allowing a complete evaluation integrating the notion of agreement between the choice and the number of tests and the complexity intrinsic to the pathology.
The visualization of low-molecule phenol (LMP) and copper naphthenate on treated wood using X-ray microtomography
Authors: Apsari Ayuni Nur , Sudoyo Eko , Alamsyah Eka Mulya , Kobayashi Kenji , Tanaka Takashi 
Published: February 2022

AbstractRecently, the plywood industry has been using low-molecule phenol (LMP) to enhance the dimensional stability of inferior-quality wood, along with copper naphthenate to increase veneer durability against staining fungi as a wood preservative. Non-destructive X-ray microtomography is a promising visualization method for reviewing the distribution of these materials. This study aimed to determine the applicability of X-ray microtomography for observing the distribution of LMP and Cu in two-and three-dimensional visualizations. The distribution mechanisms of these materials were investigated using X-ray images and image plot profiles. Six hardwood (wood from broad-leaved trees) and one softwood (wood from conifer trees) species were used for the experiments. An impregnation process was used to treat the wood samples with LMP, and copper naphthenate was added by dipping the wood in the compound for 1 s. A 10 mm2 sample of each wood species was scanned using X-ray microtomography, and the distribution of LMP and Cu was successfully visualized using X-ray microtomography with the same settings. The LMP was displayed approximately evenly throughout the veneer, whereas the copper naphthenate existed mainly on the veneer surface. The X-ray images successfully showed penetration at the microscopic scale.
British surname origins, population structure and health outcomes—an observational study of hospital admissions
Authors: Petersen Jakob , Kandt Jens , Longley Paul A. 
Published: February 2022

AbstractPopulation structure is a confounder on pathways linking genotypes to health outcomes. This study examines whether the historical, geographical origins of British surnames are associated with health outcomes today. We coded hospital admissions of over 30 million patients in England between 1999 and 2013 to their British surname origin and divided their diagnoses into 125 major disease categories (of which 94 were complete-case). A base population was constructed with patients’ first admission of any kind. Age- and sex-standardised odds ratios were calculated with logistic regression using patients with ubiquitous English surnames such as “Smith” as reference (alpha = .05; Benjamini–Hochberg false discovery rate (FDR) = .05). The results were scanned for “signals”, where a branch of related surname origins all had significantly higher or lower risk. Age- and sex-standardised admission (alpha = .05) was calculated for each signal across area deprivation and surname origin density quintiles. Signals included three branches of English surnames (disorders of teeth and jaw, fractures, upper gastrointestinal disorders). Although the signal with fractures was considered unusual overall, 2 out of the 9 origins in the branch would only be significant at a FDR > .05: OR 0.92 (95% confidence interval 0.86–0.98) and 0.70 (0.55–0.90). The risk was only different in the quintile with the highest density of that group. Differential risk remained when studied across quintiles of area deprivation. The study shows that surname origins are associated with diverse health outcomes and thus act as markers of population structure over and above area deprivation.
Evidence that large vessels do affect near infrared spectroscopy
Authors: Seddone Stefano , Ermini Leonardo , Policastro Piero , Mesin Luca , Roatta Silvestro 
Published: February 2022

AbstractThe influence of large vessels on near infrared spectroscopy (NIRS) measurement is generally considered negligible. Aim of this study is to test the hypothesis that changes in the vessel size, by varying the amount of absorbed NIR light, could profoundly affect NIRS blood volume indexes. Changes in haemoglobin concentration (tHb) and in tissue haemoglobin index (THI) were monitored over the basilic vein (BV) and over the biceps muscle belly, in 11 subjects (7 M – 4 F; age 31 ± 8 year) with simultaneous ultrasound monitoring of BV size. The arm was subjected to venous occlusion, according to two pressure profiles: slow (from 0 to 60 mmHg in 135 s) and rapid (0 to 40 mmHg maintained for 30 s). Both tHb and THI detected a larger blood volume increase (1.7 to 4 fold; p < 0.01) and exhibited a faster increase and a greater convexity on the BV than on the muscle. In addition, NIRS signals from BV exhibited higher correlation with changes in BV size than from muscle (r = 0.91 vs 0.55, p < 0.001 for THI). A collection of individual relevant recordings is also included. These results challenge the long-standing belief that the NIRS measurement is unaffected by large vessels and support the concept that large veins may be a major determinant of blood volume changes in multiple experimental conditions.
Brain information processing capacity modeling
Authors: Li Tongtong , Zheng Yu , Wang Zhe , Zhu David C. , Ren Jian , Liu Taosheng , Friston Karl 
Published: February 2022

AbstractNeurophysiological measurements suggest that human information processing is evinced by neuronal activity. However, the quantitative relationship between the activity of a brain region and its information processing capacity remains unclear. We introduce and validate a mathematical model of the information processing capacity of a brain region in terms of neuronal activity, input storage capacity, and the arrival rate of afferent information. We applied the model to fMRI data obtained from a flanker paradigm in young and old subjects. Our analysis showed that—for a given cognitive task and subject—higher information processing capacity leads to lower neuronal activity and faster responses. Crucially, processing capacity—as estimated from fMRI data—predicted task and age-related differences in reaction times, speaking to the model’s predictive validity. This model offers a framework for modelling of brain dynamics in terms of information processing capacity, and may be exploited for studies of predictive coding and Bayes-optimal decision-making.
Kinetic and isotherm insights of Diclofenac removal by sludge derived hydrochar
Authors: Oumabady Sadish , Selvaraj Paul Sebastian , Periasamy Kalaiselvi , Veeraswamy Davamani , Ramesh Paulian Thankanadathi , Palanisami Thava , Ramasamy Sangeetha Piriya 
Published: February 2022

AbstractRecently, hydrothermal carbonization emerges as the most viable option for the management of solid waste with high moisture content. Sludge derived hydrochar is used as an adsorbent for emerging contaminants or micro-pollutants in the domain of sustainability. Current study demonstrates the KOH activation of hydrochar produced from paper board mill sludge and evaluates its removal potential of a Non-steroidal anti-inflammatory drug, Diclofenac from aqueous solution. The activated hydrochars exhibited porous, spherical micro-structures with higher fraction of oxygenated functional groups paving way for the efficient adsorption of Diclofenac. The effect of initial Diclofenac concentration and contact time was ascertained using adsorption kinetics and isotherms. The adsorption kinetics exhibited second-order reaction for all adsorbents indicating higher coefficient of determination (R2 > 0.9). The Diclofenac adsorption on hydrochars followed Langmuir isotherm model with the post-activated hydrochar recording a highest adsorption capacity of 37.23 mg g−1 in 40 mg L−1 initial Diclofenac concentration at 15 h equilibrium time.
Investigating the development of diarrhoea through gene expression analysis in sheep genetically resistant to gastrointestinal helminth infection
Authors: Hassan Shamshad Ul , Chua Eng Guan , Paz Erwin A. , Kaur Parwinder , Tay Chin Yen , Greeff Johan C. , Liu Shimin , Martin Graeme B. 
Published: February 2022

AbstractGastrointestinal helminths infect livestock causing health problems including severe diarrhoea. To explore the underlying biological mechanisms relating to development and control of diarrhoea, we compared 4 sheep that were susceptible to development of diarrhoea with 4 sheep that were diarrhoea-resistant. Transcriptomes in the tissues where the parasites were located were analyzed using RNASeq. By considering low-diarrhoea sheep as control, we identified 114 genes that were down-regulated and 552 genes that were up-regulated genes in the high-diarrhoea phenotype. Functional analysis of DEGs and PPI sub-network analysis showed that down-regulated genes in the high-diarrhoea phenotype were linked to biological processes and pathways that include suppression of ‘antigen processing and presentation’, ‘immune response’, and a list of biological functional terms related to ‘suppression in immune tolerance’. On the other hand, up-regulated genes in the high-diarrhoea phenotype probably contribute to repair processes associated with tissue damage, including ‘extracellular matrix organization’, ‘collagen fibril organization’, ‘tissue morphogenesis’, ‘circulatory system development’, ‘morphogenesis of an epithelium’, and ‘focal adhesion’. The genes with important roles in the responses to helminth infection could be targeted in breeding programs to prevent diarrhoea.
Sox9 is involved in the thyroid differentiation program and is regulated by crosstalk between TSH, TGFβ and thyroid transcription factors
Authors: López-Márquez Arístides , Carrasco-López Carlos , Martínez-Cano Andrea , Lemoine Pascale , Pierreux Christophe E. , Santisteban Pilar 
Published: February 2022

AbstractWhile the signaling pathways and transcription factors involved in the differentiation of thyroid follicular cells, both in embryonic and adult life, are increasingly well understood, the underlying mechanisms and potential crosstalk between the thyroid transcription factors Nkx2.1, Foxe1 and Pax8 and inductive signals remain unclear. Here, we focused on the transcription factor Sox9, which is expressed in Nkx2.1-positive embryonic thyroid precursor cells and is maintained from embryonic development to adulthood, but its function and control are unknown. We show that two of the main signals regulating thyroid differentiation, TSH and TGFβ, modulate Sox9 expression. Specifically, TSH stimulates the cAMP/PKA pathway to transcriptionally upregulate Sox9 mRNA and protein expression, a mechanism that is mediated by the binding of CREB to a CRE site within the Sox9 promoter. Contrastingly, TGFβ signals through Smad proteins to inhibit TSH-induced Sox9 transcription. Our data also reveal that Sox9 transcription is regulated by the thyroid transcription factors, particularly Pax8. Interestingly, Sox9 significantly increased the transcriptional activation of Pax8 and Foxe1 promoters and, consequently, their expression, but had no effect on Nkx2.1. Our study establishes the involvement of Sox9 in thyroid follicular cell differentiation and broadens our understanding of transcription factor regulation of thyroid function.