bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of successful conversion surgery for locally advanced pancreatic cancer with synchronous triple cancer of the lung and esophagus: a case report
Authors: Mita Junya , Iguchi Tomohiro , Iseda Norifumi , Takada Kazuki , Hirose Kosuke , Miura Naoko , Honboh Takuya , Emi Yasunori , Akashi Tetsuro , Kato Seiya , Sadanaga Noriaki , Matsuura Hiroshi 
Published: January 2022

Abstract
Background
The number of reports of multiple primary cancer (MPC) is increasing because of the advancement in diagnostic imaging technology. However, the treatment strategy for MPCs involving pancreatic cancer is controversial because of the extremely poor prognosis. We herein report a patient with synchronous triple cancer involving the pancreas, esophagus, and lung who underwent conversion surgery after intensive chemotherapy for unresectable locally advanced pancreatic cancer.

Case presentation
A 59-year-old man was admitted to our hospital with epigastric pain, anorexia, and weight loss. Computed tomography and upper gastrointestinal endoscopy revealed that the patient had synchronous triple cancer of the pancreas, esophagus, and lung. While the esophageal and lung cancer were relatively non-progressive, the pancreatic tail cancer had invaded the aorta, celiac axis, and left kidney, and the patient was diagnosed with unresectable locally advanced disease. Because the described lesion could have been the prognostic determinant for this patient, we initiated intensive chemotherapy (gemcitabine plus nab-paclitaxel) for pancreatic cancer. After six courses of chemotherapy, the tumor size shrank remarkably and no invasion to the aorta or celiac axis was observed. No significant changes were observed in the esophageal and lung cancers; endoscopic submucosal dissection could be still a curative treatment for the esophageal cancer. Therefore, we performed curative resection for pancreatic cancer (distal pancreatomy, splenectomy, and left nephrectomy; ypT3N0cM0, ypStage IIA, UICC 8th). Pathologically, complete resection was achieved. The patient then underwent endoscopic submucosal dissection for early esophageal cancer (pT1a[M]-LPM) and video-assisted thoracoscopic right upper lobectomy in combination with right lower partial resection for early lung cancer (pT2aN0M0, pStage IB, UICC 8th). Eight months after pancreatic cancer surgery, the patient is alive and has no sign of recurrence; as a result of the successful treatment, the patient has a good quality of life.

Conclusions
Treatment of MPC is challenging, especially for cases with unresectable tumors. Although synchronous triple cancer can involve unresectable pancreatic cancer, radical resection may be possible after careful assessment of the appropriate treatment strategy and downstaging of unresectable tumors.
Unattractive faces are more attractive when the bottom-half is masked, an effect that reverses when the top-half is concealed
Authors: Pazhoohi Farid , Kingstone Alan 
Published: January 2022

AbstractFacial attractiveness in humans signals an individual’s genetic condition, underlying physiology and health status, serving as a cue to one’s mate value. The practice of wearing face masks for prevention of transmission of airborne infections may disrupt one’s ability to evaluate facial attractiveness, and with it, cues to an individual's health and genetic condition. The current research investigated the effect of face masks on the perception of face attractiveness. Across four studies, we tested if below- and above-average attractive full faces are equally affected by wearing facial masks. The results reveal that for young faces (Study 1) and old faces (Study 2) a facial mask increases the perceived attractiveness of relatively unattractive faces, but there is no effect of wearing a face mask for highly attractive faces. Study 3 shows that the same pattern of ratings emerged when the bottom-half of the faces are cropped rather than masked, indicating that the effect is not mask-specific. Our final Study 4, in which information from only the lower half of the faces was made available, showed that contrary to our previous findings, highly attractive half-faces are perceived to be less attractive than their full-face counterpart; but there is no such effect for the less attractive faces. This demonstrates the importance of the eye-region in the perception of attractiveness, especially for highly attractive faces. Collectively these findings suggest that a positivity-bias enhances the perception of unattractive faces when only the upper face is visible, a finding that may not extend to attractive faces because of the perceptual weight placed on their eye-region.
Challenges of Implementing Lung Cancer Screening in a Developing Country: Results of the Second Brazilian Early Lung Cancer Screening Trial (BRELT2)
Authors: Hochhegger Bruno , Camargo Spencer , da Silva Teles Gustavo Borges , Chate Rodrigo Caruso , Szarf Gilberto , Guimarães Marcos Duarte , Gross Jefferson Luiz , Barbosa Paula Nicole Vieira Pinto , Chiarantano Rodrigo Sampaio , Reis Rui Manuel , Mauad Edmundo Carvalho , Ghefter Mario , Sarmento Petrucio , Pereira Raphael , Rocha José , Albuquerque Marcel Lima , Miotto André , Almeida Dias Daniela Cristina , Franceschini Juliana P. , Fernando Hiran C. , dos Santos Ricardo Sales 
Published: January 2022

PURPOSE This paper aims to present the results of a series of several Brazilian institutions that have been carrying out lung cancer screening (LCS). MATERIALS AND METHODS This is a retrospective, cohort study, with follow-up of individuals of both sexes, with a heavy smoking history, who participated in LCS programs between December 2013 and January 2021 in six Brazilian institutions located in the states of São Paulo, Rio Grande do Sul, and Bahia. RESULTS Three thousand four hundred seventy individuals were included, of which 59.8% were male (n = 2,074) and 50.6% were current smokers (n = 1,758), with 60.7 years (standard deviation 8.8 years). Lung-RADS 4 was observed in 233 (6.7%) patients. Biopsy was indicated by minimally invasive methods in 122 patients (3.5%). Two patients who demonstrated false-negative biopsies and lung cancer were diagnosed in follow-up. Diagnosis of lung cancer was observed in 74 patients (prevalence rate of 2.1%), with 52 (70.3%) in stage I or II. Granulomatous disease was found in 20 patients. There were no statistical differences in the incidence of lung cancer, biopsies, granulomatous disease, and Lung-RADS 4 nodules between public and private patients. CONCLUSION There are still many challenges and obstacles in the implementation of LCS in developing countries; however, our multi-institutional data were possible to obtain satisfactory results in these scenarios and to achieve similar results to the main international studies. Granulomatous diseases did not increase the number of lung biopsies. The authors hope that it could stimulate the creation of organized screening programs in regions still endemic for tuberculosis and other granulomatous diseases.
Combination of Trastuzumab, Pertuzumab, and Docetaxel in Patients With Advanced Non–Small-Cell Lung Cancer Harboring HER2 Mutations: Results From the IFCT-1703 R2D2 Trial
Authors: Mazieres Julien , Lafitte Claire , Ricordel Charles , Greillier Laurent , Negre Elodie , Zalcman Gérard , Domblides Charlotte , Madelaine Jeannick , Bennouna Jaafar , Mascaux Céline , Moro-Sibilot Denis , Pinquie François , Cortot Alexis B. , Otto Josiane , Cadranel Jacques , Langlais Alexandra , Morin Franck , Westeel Virginie , Besse Benjamin 
Published: January 2022

PURPOSE HER2 exon 20 insertions and point mutations are oncogenic drivers found in 1%-2% of patients with non–small-cell lung cancer (NSCLC). No targeted therapy is approved for this subset of patients. We prospectively evaluated the effectiveness of the combination of two antibodies against human epidermal growth factor 2 (HER2 [HER2] trastuzumab and pertuzumab with docetaxel; trastuzumab and pertuzumab) and docetaxel. METHODS The IFCT 1703-R2D2 trial is a multicenter, nonrandomized phase II study. Patients with HER2-mutated, advanced NSCLC who progressed after ≥ 1 platinum-based treatment were enrolled. Patients received pertuzumab at a loading dose of 840 mg and 420 mg thereafter; trastuzumab at an 8 mg/kg loading dose and 6 mg/kg thereafter; and docetaxel at a dose of 75 mg/m2 every 3 weeks. The primary outcome was the objective response rate (ORR). Other end points included the duration of response, progression-free survival, and safety ( NCT03845270 ). RESULTS Forty-five patients were enrolled and treated. The median age was 64.5 years (range, 31-84 years), 35% were smokers, 72% were females, 15% had an Eastern Cooperative Oncology Group performance status of 2, and 30% had brain metastases. The objective response rate was 29% (n = 13), and 58% had stable disease (n = 26). The median progression-free survival was 6.8 months (95% CI, 4.0 to 8.5). The median duration of response in patients with a confirmed response (n = 13) was 11 months (95% CI, 2.9 to 14.9). Grade 3/4 treatment-related adverse events were observed in 64% of the patients. No patient discontinued treatment because of toxicity. The most frequent grade ≥ 3 treatment-related adverse events were neutropenia (33%), diarrhea (13%), and anemia (9%). CONCLUSION Triple therapy with trastuzumab, pertuzumab, and docetaxel is feasible and effective for HER2-mutated pretreated advanced NSCLC. These results highlight the effectiveness of the HER2 antibody-based strategy, which should be considered for these patients.
Representation of Women as Editors in Anesthesiology Journals
Authors: McMullen Kaley , Kraus Molly B. , Kosiorek Heidi , Harbell Monica W. 
Published: January 2022

BACKGROUND:
Although there has been a considerable increase in the representation of women in medicine, a gender gap still exists with regard to leadership positions. This gender discrepancy has been identified in the field of anesthesiology, in terms of first and senior authorship, as well as in general composition of editorial boards in Anesthesiology and Anesthesia & Analgesia. The goal of this study is to examine the current representation of women in editorial boards of anesthesia journals with respect to the hierarchy of different editorial positions and to assess whether there has been improvement toward equity in recent years.

METHODS:
A comprehensive search was performed for anesthesiology journals indexed in the Scimago Journal and Country Rank in May 2020. The editorial boards of the top 20 journals by impact factor were analyzed. Editorial board members were categorized based on their title. Gender was assigned using images or pronouns on research databases or hospital-affiliated websites. The percentage of women within each category was calculated. When available, the year the editors obtained their medical degree was collected. A binomial proportion test was used to analyze the distribution of women overall and among editorial roles, compared to the proportion of women anesthesiologists (26%). A Wilcoxon rank-sum test was used to compare time since medical degree between genders. Additionally, women representation in anesthesiology editorial boards in 2020 was compared to 2010.

RESULTS:
A total of 19 journals were included in this study, as 1 journal did not disclose editorial board membership. Overall, women occupied 18% of all editorial board positions. All editors-in-chief and assistant/associate/deputy editors-in-chief were men. Women consisted of 17.1% of executive/section/senior editors, 17.9% of editors, and 20.6% of associate/assistant editors. There were significantly fewer women editorial board members than the percentage of women anesthesiologists (18% vs 26%; P < .001). Editorial boards from 2010 were available for 14 journals, and of these journals, women comprised 12% of editorial board members in 2010 compared to 19% in 2020 (P = .001).

CONCLUSIONS:
These findings suggest that in anesthesiology journals, women are underrepresented at all editorial levels, especially at higher levels. As editorial boards have a significant impact on which articles are published by a journal and thereby significant influence on the specialty as a whole, the lack of gender equity in editorial boards should be addressed.
Unexpected Dissociation of Photoresponsive UV-ON DNA Carrying p-tert-Butyl Azobenzene under UV Light Irradiation
Authors: Ishii Satsuki , Murayama Keiji , Sada Kazuki , Asanuma Hiroyuki , Kakugo Akira 
Published: January 2022

Abstract
A hybridization behavior of Vis-OFF/UV-ON type photoresponsive DNA tethering p-tert-butyl azobenzene (pDNA) was investigated using fluorescence and absorbance measurement. We found that the partial dissociation of pDNA duplex into single strands occurred during UV irradiation, whereas incubation in dark after UV irradiation induced duplex formation. This feature is commonly considered to be important for an experimental design of photo-controllable system utilizing azobenzene.
Physiological, Perceptual, and Performance Responses to the 2-Week Block of High- versus Low-Intensity Endurance Training
Authors: NUUTTILA OLLI-PEKKA , NUMMELA ARI , KYRÖLÄINEN HEIKKI , LAUKKANEN JARI , HÄKKINEN KEIJO 
Published: January 2022

ABSTRACT

Purpose
This study examined the physiological, perceptual, and performance responses to a 2-wk block of increased training load and compared whether responses differ between high-intensity interval (HIIT) and low-intensity training (LIT).

Methods
Thirty recreationally trained males and females performed a 2-wk block of 10 HIIT sessions (INT, n = 15) or 70% increased volume of LIT (VOL, n = 15). Running time in the 3000 m and basal serum and urine hormone concentrations were measured before (T1) and after the block (T2), and after a recovery week (T3). In addition, weekly averages of nocturnal heart rate variability (HRV) and perceived recovery were compared with the baseline.

Results
Both groups improved their running time in the 3000 m from T1 to T2 (INT = −1.8% ± 1.6%, P = 0.003; VOL = −1.4% ± 1.7%, P = 0.017) and from T1 to T3 (INT = −2.5% ± 1.6%, P < 0.001; VOL = −2.2% ± 1.9%, P = 0.001). Resting norepinephrine concentration increased in INT from T1 to T2 (P = 0.01) and remained elevated at T3 (P = 0.018). The change in HRV from the baseline was different between the groups during the first week (INT = −1.0% ± 2.0% vs VOL = 1.8% ± 3.2%, P = 0.008). Muscle soreness increased only in INT (P < 0.001), and the change was different compared with VOL across the block and recovery weeks (P < 0.05).

Conclusions
HIIT and LIT blocks increased endurance performance in a short period. Although both protocols seemed to be tolerable for recreational athletes, a HIIT block may induce some negative responses such as increased muscle soreness and decreased parasympathetic activity.
Dataset of the adoption of digital tools for research sharing among academics in African Varsities during the COVID-19 pandemic in 2020
Authors: Owan Valentine Joseph , Uzoamaka Duruamaku-Dim Jennifer , Nonyelum Odigwe Francisca , Owan Mercy Valentine 
Published: January 2022

This dataset was collected from a total of 1,977 university lecturers across 24 African countries, that were purposively targeted due to their level of exposure to scholarly publications. The dataset was collected through an online survey that was sent to respondents through email, WhatsApp, and the Association of African Universities Telegram group. The questionnaire was designed by the researchers and validated by five experts for face and content validity. The demographic information of the data was analysed and the softcopy of the data uploaded to the Mendeley database for easy retrieval after deidentification (see Data Availability statement). The associated questionnaire can be found in the extended data. In Africa, this appears to be the broadest dataset associated with academics’ perception of utilizing digital platforms for research sharing. This implies that scholars can use this dataset to quantitatively analyse the extent to which different internet-based platforms are being utilized for research communication. Considering the current restrictions on in-person social gatherings due to COVID-19, researchers working on related studies may readily utilize this set of data, saving time and cost. A comprehensive but non-exhaustive number of 20 online platforms were assessed based on academics' awareness and current engagement with them, and the challenges they have faced using them. This offers a wide range of areas for studies to be anchored. Furthermore, researchers interested in specific online platforms can also evaluate the extent to which academic staff in African universities are aware of and willing to utilize them for research dissemination. This data will enable scholars and researchers in Africa and beyond to understand the extent to which academics in varsities are willing to adopt digital repositories for research sharing in the context of Africa.
Effect of pulsed electromagnetic field versus pulsed high intensity laser in the treatment of men with osteopenia or osteoporosis: a randomized controlled trial
Authors: Ebid Anwar , El-Shamy Shamekh , Thabet Ali , El-boshy Mohamed , Abedalla Mohamed , Ali Tariq 
Published: January 2022

Background: Osteoporosis has been related to a negative impact on several aspects of patient health, including physical, mental, and emotional well-being. The objective of this study was to examine the effects of pulsed electromagnetic fields (PEMF) and pulsed Nd-YAG laser therapy (HILT) on men with osteopenia or osteoporosis. Methods: Ninety-five men with osteopenia or osteoporosis (mean age, 52 years; mean height, 176 cm; mean weight, 83 kg; mean body-mass index (BMI), 26.86 kg/m2) took part in the study, and they were randomly assigned to one of three groups: Group 1 received PEMF and exercise program (PEMF +EX), Group 2 received HILT and exercise program (HILT+EX), and Group 3 received exercise program only (EX). PEMF was applied three times per week for 12 weeks using a full-body mat, while HILT was applied to the lower back and hip regions with a total dose of energy of 3000 J delivered in two treatment stages. Flexibility, aerobic exercise, strength, weight-bearing, and balance exercises are included in exercise program, which is followed by whole-body vibration training. Bone mineral density (BMD) of the total hip and lumbar spine, bone markers, health-related quality of life (HRQoL), and fall risk are all outcome measures. Results: There were no significant differences in the parameters between the groups at the baseline (P > 0.05). Patients in all groups, however, showed significant improvements in all measured parameters following treatment (P< 0.05), with Group 1 and Group 2 showing much greater improvements than Group 3. Conclusion: After 12-weeks of treatment, PEMF combined with exercise is more effective than HILT combined with exercise or exercise alone in increasing BMD and promoting bone formation, suppressing bone-resorption markers, and improving quality of life and fall risk, with the effects lasting up to six months. This study was registered in the ClinicalTrial.gov PRS (NCT05029440, 26/08/2021).
PRE-SERVICE TEACHER EDUCATORS ASSESSMENT OF ADEQUACY OF GOOGLE CLASSROOM APPLICATION AS TEACHING TOOLS IN TEACHER EDUCATION PROGRAMME, NIGERIA
Authors: Muhinat Bello Bolanle 
Published: January 2022

Despite the increasing number of technologies and levels of educational technology provided by teacher education programmes, valid and high-level integration of technology into learning and teaching processes is not still as expected, like theÂ Google classroom for learning. The study purposively investigated the adequacy of Google classroom application as a teaching tool in the training of pre-service teachers by their educators. Three specific purposes and questions were raised. The study adopted a descriptive survey design. Pre-service teacher educators of the Faculty of Education, University of Ilorin constituted the target population. A simple random sampling procedure was adopted in the selection of 107 out of 197 Pre-service educators. A -14 item five-point-Likert scale researchers designed a questionnaire with psychometric properties of content validity of 0.90 and a reliability index of 0.81 was used to elicit the needed data from the respondents. The statistics collected were analysed using percentage, mean ranking and standard deviation. Moreover, the findings among others revealed that Google classroom application is not adequate for training pre-service teachers. Thus, it was recommended that Google classroom application should not be adopted in the teaching of pre-service teachersâ€™ education programme since it was found not adequate
Monolithic elliptical dome Fabry–Perot microcavities exhibiting large birefringence
Authors: Hornig G. J. , Bu L. , Al-Sumaidae S. , DeCorby R. G. 
Published: January 2022

We report on the experimental and theoretical characterization of elliptically shaped Fabry–Perot microcavities fabricated through a controlled thin-film buckling process. Due to the highly astigmatic nature of the buckled mirrors, the cavity modes are well described as elliptical Hermite–Gaussian beams. In addition to lifting the typical degeneracy of higher-order transverse spatial modes, the cavities exhibit large polarization-mode splitting greater than 25 GHz in the 1550 nm wavelength range. This large, controllable, and highly predictable birefringence makes these cavities of interest for emerging applications in cavity quantum optics that rely on non-degenerate polarization modes.
COVID-19 vaccination beliefs, attitudes, and behaviours among health and social care workers in the UK: A mixed-methods study
Authors: Bell Sadie , Clarke Richard M. , Ismail Sharif A. , Ojo-Aromokudu Oyinkansola , Naqvi Habib , Coghill Yvonne , Donovan Helen , Letley Louise , Paterson Pauline , Mounier-Jack Sandra 
Published: January 2022

Background
The UK began delivering its COVID-19 vaccination programme on 8 December 2020, with health and social care workers (H&SCWs) given high priority for vaccination. Despite well-documented occupational exposure risks, however, there is evidence of lower uptake among some H&SCW groups.

Methods
We used a mixed-methods approach—involving an online cross-sectional survey and semi-structured interviews–to gain insight into COVID-19 vaccination beliefs, attitudes, and behaviours amongst H&SCWs in the UK by socio-demographic and employment variables. 1917 people were surveyed– 1656 healthcare workers (HCWs) and 261 social care workers (SCWs). Twenty participants were interviewed.

Findings
Workplace factors contributed to vaccination access and uptake. SCWs were more likely to not be offered COVID-19 vaccination than HCWs (OR:1.453, 95%CI: 1.244–1.696). SCWs specifically reported uncertainties around how to access COVID-19 vaccination. Participants who indicated stronger agreement with the statement ‘I would recommend my organisation as a place to work’ were more likely to have been offered COVID-19 vaccination (OR:1.285, 95%CI: 1.056–1.563). Those who agreed more strongly with the statement ‘I feel/felt under pressure from my employer to get a COVID-19 vaccine’ were more likely to have declined vaccination (OR:1.751, 95%CI: 1.271–2.413). Interviewees that experienced employer pressure to get vaccinated felt this exacerbated their vaccine concerns and increased distrust. In comparison to White British and White Irish participants, Black African and Mixed Black African participants were more likely to not be offered (OR:2.011, 95%CI: 1.026–3.943) and more likely to have declined COVID-19 vaccination (OR:5.550, 95%CI: 2.294–13.428). Reasons for declining vaccination among Black African participants included distrust in COVID-19 vaccination, healthcare providers, and policymakers.

Conclusion
H&SCW employers are in a pivotal position to facilitate COVID-19 vaccination access, by ensuring staff are aware of how to get vaccinated and promoting a workplace environment in which vaccination decisions are informed and voluntary.