bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remotely Delivered Exercise to Rural Older Adults With Knee Osteoarthritis: A Pilot Study
Authors: Patel Kushang V. , Hoffman Elise V. , Phelan Elizabeth A. , Gell Nancy M. 
Published: June 2022

ObjectiveEnhanceFitness (EF) is an evidence‐based exercise program recommended for management of osteoarthritis (OA). However, access to EF is limited in rural areas. Accordingly, we evaluated the feasibility and acceptability of remotely delivered EF (tele‐EF) in rural, community‐dwelling older adults with symptomatic knee OA.MethodsA single‐arm pilot trial of tele‐EF classes was conducted. Videoconferencing was used to livestream the instructor‐led, 1‐hour EF classes 3 days/week for 12 weeks. Outcomes were assessed at baseline and immediately post intervention.ResultsA total of 15 of 27 potential participants (55%) were screen eligible and enrolled into the trial. Participants had a median age of 70 years (interquartile range: 67‐75), and 14 (93%) were women. The median EF class attendance rate was 91% (interquartile range: 85%‐94%). Knee pain, as measured by the Knee Injury and Osteoarthritis Outcome Score (KOOS), improved significantly from baseline to the 12‐week end point (mean difference = −11.4 [95% confidence interval (CI): −20.9 to −2.0]; P = 0.02). In addition, participants’ self‐reported knee function improved significantly (mean difference in KOOS function score = −11.8 [95% CI: −18.4 to −5.2]; P < 0.01) as well as their physical capacity (mean difference in Timed Up and Go test time = 1.8 seconds [95% CI: 0.2‐3.4]; P = 0.03). All participants (100%) were very satisfied with tele‐EF classes, and 12 participants (86%) reported that their condition had much improved or very much improved since beginning the EF exercise program. Lastly, there were no serious adverse events.ConclusionFindings from this pilot trial indicate that tele‐EF is feasible and acceptable in rural older adults with knee OA.
Cytoprotection of Human Progenitor and Stem Cells through Encapsulation in Alginate Templated, Dual Crosslinked Silk and Silk–Gelatin Composite Hydrogel Microbeads
Authors: Hasturk Onur , Smiley Jordan A. , Arnett Miles , Sahoo Jugal Kishore , Staii Cristian , Kaplan David L. 
Published: June 2022

AbstractSusceptibility of mammalian cells against harsh processing conditions limit their use in cell transplantation and tissue engineering applications. Besides modulation of the cell microenvironment, encapsulation of mammalian cells within hydrogel microbeads attract attention for cytoprotection through physical isolation of the encapsulated cells. The hydrogel formulations used for cell microencapsulation are largely dominated by ionically crosslinked alginate (Alg), which suffer from low structural stability under physiological culture conditions and poor cell–matrix interactions. Here the fabrication of Alg templated silk and silk/gelatin composite hydrogel microspheres with permanent or on‐demand cleavable enzymatic crosslinks using simple and cost‐effective centrifugation‐based droplet processing are demonstrated. The composite microbeads display structural stability under ion exchange conditions with improved mechanical properties compared to ionically crosslinked Alg microspheres. Human mesenchymal stem and neural progenitor cells are successfully encapsulated in the composite beads and protected against environmental factors, including exposure to polycations, extracellular acidosis, apoptotic cytokines, ultraviolet (UV) irradiation, anoikis, immune recognition, and particularly mechanical stress. The microbeads preserve viability, growth, and differentiation of encapsulated stem and progenitor cells after extrusion in viscous polyethylene oxide solution through a 27‐gauge fine needle, suggesting potential applications in injection‐based delivery and three‐dimensional bioprinting of mammalian cells with higher success rates.
Topological Crystalline Insulator Candidate ErAsS with Hourglass Fermion and Magnetic‐Tuned Topological Phase Transition
Authors: Chen Hongxiang , Gao Jiacheng , Chen Long , Wang Gang , Li Hang , Wang Yulong , Liu Juanjuan , Wang Jinchen , Geng Daiyu , Zhang Qinghua , Sheng Jieming , Ye Feng , Qian Tian , Chen Lan , Weng Hongming , Ma Jie , Chen Xiaolong 
Published: June 2022

AbstractTopological crystalline insulators (TCIs) with hourglass fermion surface state have attracted a lot of attention and are further enriched by crystalline symmetries and magnetic order. Here, the emergence of hourglass fermion surface state and exotic phases in the newly discovered, air‐stable ErAsS single crystals are shown. In the paramagnetic phase, ErAsS is expected to be a TCI with hourglass fermion surface state protected by the nonsymmorphic symmetry. Dirac‐cone‐like bands and nearly linear dispersions in large energy range are experimentally observed, consistent well with theoretical calculations. Below TN ≈ 3.27 K, ErAsS enters a collinear antiferromagnetic state, which is a trivial insulator breaking the time‐reversal symmetry. An intermediate incommensurate magnetic state appears in a narrow temperature range (3.27–3.65 K), exhibiting an abrupt change in magnetic coupling. The results reveal that ErAsS is an experimentally available TCI candidate and provide a unique platform to understand the formation of hourglass fermion surface state and explore magnetic‐tuned topological phase transitions.
Spin‐Mixing Enhanced Proximity Effect in Aluminum‐Based Superconductor–Semiconductor Hybrids
Authors: Mazur Grzegorz P. , van Loo Nick , Wang Ji‐Yin , Dvir Tom , Wang Guanzhong , Khindanov Aleksei , Korneychuk Svetlana , Borsoi Francesco , Dekker Robin C. , Badawy Ghada , Vinke Peter , Gazibegovic Sasa , Bakkers Erik P. A. M. , Pérez Marina Quintero‐ , Heedt Sebastian , Kouwenhoven Leo P. 
Published: June 2022

AbstractIn superconducting quantum circuits, aluminum is one of the most widely used materials. It is currently also the superconductor of choice for the development of topological qubits. However, aluminum‐based devices suffer from poor magnetic field compatibility. Herein, this limitation is resolved by showing that adatoms of heavy elements (e.g., platinum) increase the critical field of thin aluminum films by more than a factor of two. Using tunnel junctions, it is shown that the increased field resilience originates from spin‐orbit scattering introduced by Pt. This property is exploited in the context of the superconducting proximity effect in semiconductor–superconductor hybrids, where it is shown that InSb nanowires strongly coupled to Al/Pt films can maintain superconductivity up to 7 T. The two‐electron charging effect is shown to be robust against the presence of heavy adatoms. Additionally, non‐local spectroscopy is used in a three‐terminal geometry to probe the bulk of hybrid devices, showing that it remains free of sub‐gap states. Finally, it is demonstrated that proximitized semiconductor states maintain their ability to Zeeman‐split in an applied magnetic field. Combined with the chemical stability and well‐known fabrication routes of aluminum, Al/Pt emerges as the natural successor to Al‐based systems and is a compelling alternative to other superconductors, whenever high‐field resilience is required.
Accessing Excitation‐ and Time‐Responsive Afterglows from Aqueous Processable Amorphous Polymer Films through Doping and Energy Transfer
Authors: Wang Zhengshuo , Li Anze , Zhao Zihao , Zhu Tianwen , Zhang Qiang , Zhang Yongzhi , Tan Yeqiang , Yuan Wang Zhang 
Published: June 2022

AbstractSmart afterglow materials in response to excitation and delay time, including crystals, polymeric films, and carbon dots, have attracted considerable attention on account of their fundamental value in photophysics and promising applications in optoelectronics. However, the fabrication of amorphous and flexible polymer films with fine control remains underexplored. Herein, new doped polymer films based on sodium alginate and aromatic carboxylates are developed, which demonstrate following advantages: (i) easy and fast fabrication through the aqueous solution process, (ii) flexible, transparent, and re‐dissolvable characteristics, (iii) multi‐tunable afterglow colors from blue to red and even white with fine control. Specifically, even better controllability can be achieved through co‐doping and triplet‐to‐singlet Förster resonance energy transfer (TS‐FRET). Multimode advanced anti‐counterfeiting of these materials is demonstrated using their excitation‐ and time‐dependent as well as TS‐FRET‐mediated afterglow colors.
A Snakeskin‐Inspired, Soft‐Hinge Kirigami Metamaterial for Self‐Adaptive Conformal Electronic Armor
Authors: Jiang Shan , Liu Jianpeng , Xiong Wennan , Yang Zhaoxi , Yin Liting , Li Kan , Huang YongAn 
Published: June 2022

AbstractA majority of soft‐body creatures evolve armor or shells to protect themselves. Similar protection demand is for flexible electronics working in complex environments. Existing works mainly focus on improving the sensing capabilities such as electronic skin (E‐skin). Inspired by snakeskin, a novel electronic armor (E‐armor) is proposed, which not only possesses mechanical flexibility and electronic functions similar to E‐skin, but is also able to protect itself and the underlying soft body from external physical damage. The geometry of the kirigami mechanical metamaterial (Kiri‐MM) ensures auxetic stretchability and meanwhile large areal coverage for sufficient protection. Moreover, to suppress the inherent but undesired out‐of‐plane buckling of conventional Kiri‐MMs for conformal applications, soft hinges are used to form a distinct soft (hinges)‐rigid (tiles) configuration. Analytical, computational, and experimental studies of the mechanical behaviors of the soft‐hinge Kiri‐MM E‐armor demonstrate the merits of this design, i.e., stretchability, conformability, and protectability, as applied to flexible electronics. Deploying a conductive soft material at the hinges enables facile wiring strategies for large‐scale circuit arrays. Functional E‐armor systems for controllable display and sensing purposes provide simple examples of a wide spectrum of applications of this concept.
Electrochemical Decarboxylative Coupling of N‐Substituted Glycines under Air: Access to C3‐Aminomethylated Imidazo[1,2‐a]pyridines
Authors: Li Sifeng , Li Xingchen , Wang Taimin , Yang Qingjing , Ouyang Zijun , Chen Jieyu , Zhai Hongbin , Li Xiao , Cheng Bin 
Published: June 2022

AbstractAn electrochemical decarboxylative aminomethylation reaction of imidazo[1,2‐a]pyridines with various N‐substituted glycines in acetonitrile at room temperature has been described. The reaction could be conducted under light‐free, catalyst‐free, oxidant‐free, and air conditions, affording the C3‐aminomethylated imidazo[1,2‐a]pyridines in good to high yields. Remarkably, N‐aryl, N,N‐dialkyl, and N‐alkyl‐N‐aryl glycines are all well‐tolerated in this easily handled protocol, which further expands the chemical space of bioactive imidazo[1,2‐a]pyridine derivatives.magnified image
Superconducting Proximity Effect in d‐Wave Cuprate/Graphene Heterostructures
Authors: Perconte David , Bercioux Dario , Dlubak Bruno , Seneor Pierre , Bergeret Fernando Sebastian , Villegas Javier E. 
Published: June 2022

AbstractSuperconducting proximity effects in graphene have received a great deal of attention for over a decade now. This has unveiled a plethora of exotic effects linked to the specificities of graphene's electronic properties. The vast majority of the related studies are based on conventional, low‐temperature superconducting metals with isotropic s‐wave pairing. Here recent advances made on the less studied case of unconventional high‐temperature superconducting cuprates are reviewed. These are characterized by an anisotropic d‐wave pairing, whose interplay with Dirac electrons yields very rich physics and novel proximity behaviors. A theoretical analysis is provided and the experiments reported so far are summarized. These unveil hints of proximity‐induced unconventional pairing and demonstrate the gate‐tunable, long‐range propagation of high‐temperature superconducting correlations in graphene. Finally, the fundamental and technological opportunities brought by the theoretical and experimental advances are discussed, together with the interest in extending similar studies to other Dirac materials.
Multicomponent Crystals with Competing Intermolecular Interactions: In Situ X‐ray Diffraction and Luminescent Features Reveal Multimolecular Assembly under Mechanochemical Conditions
Authors: Yano Yoshio , Kasai Hidetaka , Zheng Yanyan , Nishibori Eiji , Hisaeda Yoshio , Ono Toshikazu 
Published: June 2022

AbstractSupramolecular chemistry under mechanochemical conditions has drawn attention because it can induce low‐solubility molecules to self‐assemble, although most of the reported examples have been limited to two‐component systems. We applied mechanochemical synthesis to achieve multimolecular self‐assembly in more challenging three‐component systems. The produced crystals showed multicolor solid‐state luminescence depending on the components when exposed to UV light. Optical outputs and X‐ray diffraction studies were used to examine the self‐assembling behavior in greater depth. Using synchrotron radiation, in situ X‐ray diffraction permitted direct observation of the milling process, which started the self‐assembly process within 1 min. This research emphasizes the importance of multicomponent molecules with optical functions and self‐assembling behavior and offers the possibility of developing more complicated multicomponent crystals and organic solid solutions for advanced materials.
Protonengradienten erhöhen die Sensitivität von in Liposomen eingeschlossenen supramolekularen Chemosensoren
Authors: Nilam Mohamed , Karmacharya Shreya , Nau Werner M. , Hennig Andreas 
Published: June 2022

AbstractEine umfassende Herausforderung in der Entwicklung supramolekularer Sensorsysteme ist die Verbesserung ihrer Sensitivität, was für gewöhnlich die Synthese verbesserter Rezeptoren mit erhöhter Affinität für den Analyten beinhaltet. Wir zeigen, dass eine ausgeprägte Sensitivitätsverbesserung um ein bis zwei Größenordnungen dadurch erreicht werden kann, dass supramolekulare Chemosensoren in Liposomen eingeschlossen werden, die einem pH‐Gradienten über die Lipiddoppelschicht ausgesetzt sind. Dies hat ein Ungleichgewicht der Zu‐ und Abflussgeschwindigkeiten von basischen und sauren Analyten in das Liposom zur Folge und führt zu einer signifikant erhöhten Analytkonzentration im Inneren des Liposoms. Der Nutzwert unserer mit Liposomen verbesserten Sensoren wurde mit verschiedenen Wirt‐Farbstoff‐Reporterpaaren und Sensormechanismen gezeigt, und wir konnten sehr einfach die Sensitivität für mehrere biologisch wichtige Analyten, inklusive der Neurotransmitter Serotonin und Tryptamin, signifikant erhöhen.
Adaptive soft sensor based on transfer learning and ensemble learning for multiple process states
Authors: Yamada Nobuhito , Kaneko Hiromasa 
Published: June 2022

AbstractThe objective of this study is to develop an adaptive software sensor technique that can predict objective process variables for a target grade in a plant while also considering information related to various other grades. We use a dataset of the target grade as the target domain and those of the other grades as source domains to perform transfer learning. Multiple models or sub‐models are constructed by setting a source domain for each grade and changing the number of samples used as the source domain. Furthermore, to prevent the negative transfer, the use of a source domain is automatically judged. In this study, we constructed sub‐models using the locally weighted partial least squares approach as an adaptive soft sensor technique. The values of an objective variable were predicted with ensemble learning using sub‐models. The effectiveness of the proposed method was verified using a dataset measured in an actual incineration plant, and the proposed method was able to accurately predict the product quality even when the plant was operated in five grades and when a new grade was produced.
Rapid and Ultrasensitive Electrochemical Detection of TP53 Gene Mutation in Blood: Hybridization with a DNA/Gold‐Coated Magnetic Nanoparticle Network
Authors: Chen Dongfei , Wu Yanfang 
Published: June 2022

AbstractMutant TP53 has been demonstrated to be a promising biomarker as it is the most frequently mutated gene in human cancer. However, quantifying TP53 mutation presents two unique challenges: a broad concentration range and ultralow abundance. This study reports on the development of an ultrasensitive and highly‐selective electrochemical biosensor for the rapid detection of TP53 mutation in blood. TP53 mutation analysis is based on a network of gold‐coated magnetic nanoparticles modified with probe DNA (DNA−Au@MNPs). The DNA−Au@MNPs biosensor can rapidly and selectively detect TP53 gene with a single‐base mutation at a high background of wild‐type TP53 gene in blood. Moreover, the sensor presents a broad dynamic range of 1 aM to 10 nM for the mutant TP53 gene with the lowest detected concentration of 1 aM and significantly reduced response time of 20 min. Therefore, this biosensor demonstrates the potential to be used for minimally invasive analysis of cancer.
Real‐world evidence following a mandatory treatment break after a 1‐year prophylactic treatment with calcitonin gene‐related peptide (pathway) monoclonal antibodies
Authors: Nsaka Michael , Scheffler Armin , Wurthmann Sebastian , Schenk Hannah , Kleinschnitz Christoph , Glas Martin , Holle Dagny 
Published: June 2022

AbstractBackgroundCurrent German and European guidelines suggest migraine patients undertake a treatment break after 9 to 12 months of treatment with CGRP (pathway) monoclonal antibodies.MethodsClinical routine data of highly resistant migraine patients were analyzed before treatment with CGRP monoclonal antibodies (baseline), after 12 months of treatment, and following a treatment break between November 2018 and December 2020 in the West German Headache Centre, University Hospital Essen, Germany. Monthly migraine days (MMD), monthly headache days (MHD), and days of acute medication intake (AMD) were assessed.ResultsComplete clinical data from 46 migraine patients (14 episodic migraine (EM), 32 chronic migraine (CM) patients) treated with erenumab (n = 40), galcanezumab (n = 4), and fremanezumab (n = 2) were analyzed. The mean number of MMDs among EM and CM patients after 12 months of CGRP antibody treatment increased during the treatment break by 5.18 (SE 0.92, p < .001) and 5.06 (SE 1.22, p = .003) days, respectively. There was an increased intake of acute medications among episodic (4.72, SE 0.87, p = .004) and chronic migraine patients (3.01, SE 1.08, p = .013) during treatment break. Eighty‐three percent of patients (n = 38) were dissatisfied with the mandatory treatment break. All patients continued with a CGRP (pathway) monoclonal antibody after the mandatory treatment break.ConclusionA mandatory break in CGRP (pathway) monoclonal antibody therapy had a negative short‐term impact on migraine patients.
Identification of novel somatic fusions of ERG‐VEGFA, TMPRSS2‐ERG, and VEGFA‐TMPRSS2 in prostate cancer treated with anlotinib and androgen deprivation therapy: A case report
Authors: Liu Qiuli , Wang Shuo , Wang Ze , Tang Peng , Zhang Dianzheng , Lan Weihua , Jiang Jun 
Published: June 2022

AbstractThe TMPRSS2‐ERG fusion gene has frequently been found in prostate cancer and is associated with malignancy. Identifying novel fusions will help to stratify patients and establish patient‐tailored therapies. A 78‐year‐old man presented to our hospital with severe symptoms of urinary urgency and frequency for 2 years, as well as severe bone pain for 1 year. He was diagnosed with metastatic prostate cancer with a Gleason score of 5 + 5. Three gene fusions, ERG_VEGFA, TMPRSS2_ERG, and VEGFA_TMPRSS2, were identified in the patient's prostate cancer tissue. Notably, administration of the tyrosine kinase inhibitor, anlotinib, in combination with a gonadotropin‐releasing hormone agonist (GnRHa) and abiraterone, reduced the patient's bone pain and also stabilized his prostate cancer for more than 2 years. This is the first report of somatic fusions among the VEGFA, ERG, and TMPRSS2 genes in cancer tissues from a patient with prostate cancer who responded well to antiangiogenic treatment combined with a GnRHa and abiraterone.
Biochemical recurrence related metabolic novel signature associates with immunity and ADT treatment responses in prostate cancer
Authors: Wang Xuan , Lv Zhengtong , Xia Haoran , Guo Xiaoxiao , Wang Jianye , Wang Jianlong , Liu Ming 
Published: June 2022

AbstractBackgroundProstate cancer (PCa) is a unique cancer from a metabolic perspective. Androgen receptor assumes a vital part in normal and malignant prostate cells regarding almost all aspects of cell metabolism, such as glucose, fat, amino acids, nucleotides, and so on.MethodsWe used The Cancer Genome Atlas database as training set, Memorial Sloan‐Kettering Cancer Center cohort as validation set, and Gene Expression Omnibus database (GSE70769) as test set to identify the optimal prognostic signature. We evaluated the signature in terms of biochemical progression‐free survival (bPFS), ROC curve, clinicopathological features, independent prognostic indicators, tumor microenvironment, and infiltrating immune cells. Nomogram was built dependent on the results of cox regression analyses. GSEA algorithm was used to evaluate differences in metabolism. The signature's prediction of androgen deprivation therapy (ADT) response was validated based on two groups of basic cytological experiments treat with ADT (GSE143408 and GSE120343) and the transcriptional information of pre‐ADT/post‐ADT of six local PCa patients.ResultsWe finally input four screened genes into the stepwise regression model to construct metabolism‐related signature. The signature shows good prediction performance in training set, verification set, and test set. A nomogram based on the PSA, Gleason score, T staging, and the signature risk score could predict 1‐, 3‐, and 5‐year bPFS with the high area under curve values. Based on gene‐set enrichment analysis, the characteristics of four genes signature could influence some important metabolic biological processes of PCa and were serendipitously found to be significantly related to androgen response. Subsequently, two cytological experimental data sets and our local patient sequencing data set verified that the signature may be helpful to evaluate the therapeutic response of PCa to ADT.ConclusionsOur systematic study definite a metabolism‐related gene signature to foresee prognosis of PCa patients which might add to individual prevention and treatment.
Landscape Rippling: Context‐based water‐mediated interaction design
Authors: Lin Weiyue , Hong Haoran , She Yingying , Yang Baorong 
Published: June 2022

AbstractWith a core purpose of helping users to understand the context, a water interface provides possibility for enhancing user experience in interaction process. Starting from analyzing existing water‐mediated interaction approaches, we proposed a water‐mediated interaction design model and a corresponding user experience model, aiming to eliminate the boundary between users and the context with water as the medium. According to the proposed model, we implemented a water‐mediated interaction system Landscape Rippling, with the painting “A Panorama of Rivers and Mountains” as its context. Ultimately, user experience tests of the interaction system demonstrate the effectiveness of this water‐mediated interaction design model.