bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Photocatalytic Performance of CdFe2O4/Al2O3 Nanocomposite for Dye Degradation
Authors: Varpe Ashwini S. , Deshpande Mrinalini D. , Tope Dipak R. , Borhade Ashok V. 
Published: August 2022

Abstract
In the present work, CdFe2O4/Al2O3 magnetic nanocomposite photocatalyst is successfully synthesized by simple sol-gel auto-combustion method. The photocatalytic activity of the samples was evaluated by the xylenol orange (XO) dye degradation under UV light. The influence of Al2O3 concentration with CdFe2O4 on the catalytic property is also studied. We have considered three weight percentage of Al2O3, 5%, 10% and 20% with CdFe2O4. All the samples are characterized with XRD, BET, FTIR, FESEM, TEM, UV-Visible, and VSM techniques. The degradation process of the dye is monitored spectrophotometrically. The photocatalytic activity of the samples is evaluated by the xylenol orange (XO) dye degradation under UV light. The performance in terms of removal efficiency is studied by varying the contact time, dye concentration and amount of catalyst. Among the three concentrations of Al2O3 with CdFe2O4, the 10% weight concentration of Al2O3 with CdFe2O4 is found to be the optimal concentration and showed the higher degradation rate. After 30 min photocatalytic reaction, the degradation rate is 92.29% for 10% CdFe2O4/Al2O3 and for bare CdFe2O4 it is 85.79%. The lower particle size, higher surface area, enhanced porosity, considerable band gap, and higher saturation magnetization is found as compared to that of 5% and 20% CdFe2O4/Al2O3 as well as bare CdFe2O4 nanoparticles. It is found that, the photocatalytic activity of synthesized nanocomposite is higher than CdFe2O4 (85.79%). The stability of the composite material is also investigated by performing consecutive runs. This work affords a new reference for designing spinel ferrites/Al2O3 nanocomposite and its application for environmental purification.
Polytrauma: Skeletal Injury Patterns and Associations
Authors: Kumar Pratik , Bhuyan Sanjeev Kumar 
Published: August 2022

Abstract
Background
Polytrauma fulfills the disease classification criteria for a global pandemic, being a significant cause of morbidity and mortality. Skeletal injuries in polytrauma patients, maximally affect the functional outcome and quality of life after the injury. However, there is little epidemiological data on skeletal and associated injuries in polytrauma patients.
Methods
A prospective study was conducted at a tertiary-care hospital on patients presenting with history of trauma. Patient’s injuries were coded as per Abbreviated Injury Scale (AIS) and categorized as polytrauma on the basis of New Injury Severity Score (NISS > 16). Skeletal injuries were classified as per AO/Muller classification and Open fractures classified by Gustilo-Anderson system.
Results
647 patients of age ≥ 16 and NISS ≥ 16 sustained 1353 skeletal injuries with an average of 2.09 fractures/dislocations per patient. Majority were young male adults sustaining injury following a RTA having head injury as commonest association. A mean ISS of 24.9 and NISS of 27.5 was observed. Femur and tibia sustained maximum injury. 16.2% of the skeletal injury were open with 57.5% of the skeletal injuries requiring surgical intervention in some form.
Conclusion
The purpose of this prospective study was to obtain data on the epidemiology of polytrauma and assess skeletal injuries and its associations.It’s obvious that majority of patient were young adults leading to considerable workforce and economic loss to society. This points to the burden of polytrauma and warrants requirements of a dedicated trauma team and other resources to improve mortality and morbidity statistics as well as patient outcome.
A mixed-method feasibility study of a new digital health support package for people after stroke: The Recovery-focused Community support to Avoid readmissions and improve Participant are Stroke (ReCAPS) intervention
Authors: Cameron Janette , Lannin Natasha A , Harris Dawn , Andrew Nadine E , Kilkenny Monique F , Purvis Tara , Thrift Amanda G , Thayabaranathan Tharshanah , Ellery Fiona , Sookram Garveeta , Hackett Maree , Kneebone Ian , Drummond Avril , Cadilhac Dominique A 
Published: August 2022

Abstract
Background: Evidence for digital health programs to support people living with stroke is limited. We assessed the feasibility of a protocol and procedures for the Recovery-focused Community support to Avoid readmissions and improve Participation after Stroke (ReCAPS) intervention. Method: We conducted a mixed-method feasibility study. Participants with acute stroke were recruited from three hospitals (Melbourne, Australia). Eligibility: Adults discharged home within 10 days of hospital admission, modified Rankin Score 0-4, and prior use of Short Message System (SMS) or email. While in hospital participants contributed to structured person-centred goal setting with clinicians, provided responses to surveys including assessment of self-management skills and health-related quality of life. Participants were randomised 7-14 days after discharge via REDCap® (1:1 allocation). Following randomisation, the intervention group received a 12-week program of personalised electronic support messages (average 66 messages sent by SMS or email) aligned to their goals. The control group received six electronic administrative messages. Feasibility outcomes included: number of patients screened and recruited, study retainment, completion of outcome measures, number of electronic messages delivered, and acceptability of the ReCAPS intervention and trial procedures (participant satisfaction survey, clinician interviews and researcher communications). We undertook inductive thematic analysis of interview/open-text survey data, and descriptive analysis of closed survey questions.Results: Between November 2018 and October 2019, 312 patients were screened; 37/105 (35%) eligible patients provided consent (mean age 61 years; 32% female); 33 were randomised (17 to intervention). Outcome assessments at 12-weeks were completed by 88% of participants with 16 also completing the satisfaction survey (intervention=10). Overall, trial participants felt that the study was worthwhile and most would recommend it to others. Six clinicians participated in one of three focus group interviews; while they reported that the trial and the process of goal setting acceptable, they raised concerns regarding the additional time required to personalise goals. Conclusion: The study protocol and procedures were feasible with acceptable retention of participants. Consent and goal personalisation procedures should be centralised for the Phase III trial to reduce the burden on hospital clinicians. Trial Registration: Australian New Zealand Clinical Trials Registry: ACTRN12618001468213 (Date 31/08/2018); Universal Trial Number: U1111-1206-7237
Energy and air? The impact of energy efficiency improvement on air quality in China
Authors: An Bo-Wen , Liu Wei , Basang Tsering-Xiao , Li Chun-Yu , Xiao Yi 
Published: August 2022

Abstract
Energy shortage and air pollution are the two key issues hindering global economic development. And the optimal measure to improve air quality is by increasing energy efficiency. The influence of energy efficiency, socioeconomic and natural climatic factors on air quality is analyzed under the theory of STIRPAT. The energy efficiency is measured using the super SBM model while air pollutants are estimated by sulfur dioxide (SO2), nitrogen oxides (NOx) and dust and smoke (DS). It is highly coupled between the energy efficiency and the spatial distribution of air quality. Increased energy efficiency can improve air quality by reducing SO2 and NOx, but the impact on DS is not significant. Air pollutants decrease by about 0.5313% for every 1% increase in temperature and 0.1046% for every 1% increase in precipitation. Consumption will exacerbate air pollution, and there is an inverted U-shaped relationship between population density, economic scale, urbanization, technology innovation and air pollution. It is worth mentioning that this work adds temperature and precipitation to the STIRPAT as natural climatic factors, analyzing the impact of energy efficiency on air pollution under the two-factor restrictions of socioeconomic and natural climatic factors. Finally, management suggestions are made in order to improve air quality.
Technology-Enabled Virtual Ward for COVID Management of the Elderly and Immunocompromised in Singapore: A Descriptive Cohort
Authors: Ko Stephanie Q , Kumar Shoban Krishna , Jacob Jonathan , Hooi Benjamin MY , Soo Michelle , Nashi Norshima , Cruz Maria Teresa D , Yeo Ai Wah , Wong Zhi Xin , Smitasin Nares , Lum Lionel , Archuleta Sophia 
Published: August 2022

Abstract
Background: To address the hospital bed demand for Delta and Omicron surges in Singapore, the National University Health System (NUHS) developed a COVID Virtual Ward to relieve bed pressures on its three acute hospitals – National University Hospital, Ng Teng Fong General Hospital, Alexandra Hospital. To serve a multilingual population, the COVID Virtual Ward featuring protocolized teleconsultation of high-risk patients, use of a vital signs chatbot, supplemented by home visits where necessary. This study aims to evaluate the safety, outcomes and utilisation of the Virtual Ward as a scalable response to COVID-19 surges.Methods: This is a retrospective cohort study of all patients admitted to the COVID Virtual Ward between 23 September to 9 November 2021. Patients were defined as “early discharge” if they were referred from inpatient COVID-19 wards and “admission avoidance” if they were referred directly from primary care or emergency services. Patient demographics, utilisation measures and clinical outcomes were extracted from the electronic health record system. The primary outcomes were escalation to hospital and mortality. Use of the vital signs chatbot was evaluated by examining compliance levels, need for automated reminders and alerts triggered. Patient experience was evaluated using data extracted from a quality improvement feedback form.Results: 238 patients were admitted to the COVID Virtual Ward from 23 September to 9 November, of whom 42% were male, 67.9% of Chinese ethnicity. 43.7% were over the age of 70, 21% were immunocompromised, and 36.6% were not fully vaccinated. 17.2% of patients were escalated to hospital, with no significant difference between the early discharge and admission avoidance cohorts (adjusted OR 0.77 [95% CI 0.39-1.56]) and 1.2% of patients died. There were no missed deteriorations. All patients received teleconsults (median of 5 teleconsults per patient, IQR 3-7). 22.7% of patients received home visits. 77.7% of patients engaged with the vital signs chatbot, with a compliance rate of 84%. All patients would recommend the programme to others in their situation. Conclusions: Virtual Wards are a scalable, safe and patient-centered strategy to care for high risk COVID-19 patients at home.Trial Registration: NA
A novel ferroptosis-related gene signature associated with Helicobacter pylori for prognosis prediction in patients with gastric cancer
Authors: Liu Qi , Ji Mingyu , Zhao Xin , Liu Duanrui , Xu Mingjie , Qu Xue , Li Huanjie , Jia Yanfei , Zhou Yunying , Wang Yunshan , Han Shuyi 
Published: August 2022

Abstract
BackgroundGastric Cancer (GC) is a seriously heterogeneous disease, making the prognostic prediction challenging. The causal relationship between helicobacter pylori (Hp) infection and GC has been tightly entrenched by numerous epidemiological and clinical studies. Ferroptosis, a novel form of regulated cell death, is closely related to the increase and development of malignant tumors. ROS plays a key role in ferroptosis, whereas ROS produced by HP in some patients with GC also plays an important role in tumor progression. Whether the induction of ferroptosis can play a better role in the clinical treatment of GC caused by HP infection remains to be further studied. Therefore, the mRNA expression profiles and corresponding clinical data of patients with GC were downloaded from public databases. Methods Univariate Cox regression and LASSO regression were used to construct a multigene signature in the TCGA cohort. Patients with GC from the Gene Expression Omnibus (GEO) cohort were used for validation. The results showed that six differentially expressed genes (DEGs) were correlated with prognosis. Then, GSVA algorithm was used to calculate the enrichment score of each sample based on the six genes. Patients were divided into two risk groups (low and high) by the median risk score evaluated with the enrichment score and found statistically significant differences in their survival rates. ResultsA novel prognostic model integrating six ferroptosis-related and HP-related genes were firstly constructed, and a nomogram combining DEG signature with clinical features was constructed to confirm the robustness of the model for speculating about RFS in patients with GC. The receiver operating characteristic (ROC) curve, independent GEO datasets, and our experiments at the cellular level and with RNA extracted from patient tissues indicated that the signature endows a good predictive performance. The functions of this gene signature were assessed by gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) analysis. Additionally, immune infiltration analysis, gene mutation analysis, and molecular docking were used to explore the potential mechanism of this gene signature.ConclusionsConclusively, a novel gene signature can be used for the prognostic prediction of GC. Targeting ferroptosis and HP may be a therapeutic alternative for patients with GC.
Tissue factor links inflammation, thrombosis, and senescence in COVID-19
Authors: Nguyen Dayna , Lee Jeongwu 
Published: August 2022

Abstract
COVID-19 is a highly contagious respiratory infection that induces inflammatory and thrombotic responses. Upon SARS-CoV-2 entry into lung epithelial cells, infected cells secrete a group of chemokines known as the senescence associated secretory phenotype (SASP). These SASP factors induce the harmful COVID-19 cytokine storm by recruiting and activating inflammatory immune cells. Recent studies propose viral-induced senescence (VIS) is responsible for releasing these SASP factors and exacerbating inflammation in COVID-19. However, it is still unclear how thrombosis, inflammation, and senescence are connected, and whether senescence is commonly triggered after infection. Additionally the underlying mechanism of thrombosis in COVID-19 remains unknown. Here, we conducted meta-analysis of single-cell and bulk RNA sequencing data from multiple patient studies, animal models, and cell lines infected with SARS-CoV-2 and other respiratory viruses. We found that SASP factors are prevalent in infected patients and that tissue factor (F3), initiator of the extrinsic coagulation pathway, was positively correlated with SASP expression. Notably, F3 is overexpressed in various respiratory viral infections including COVID-19 and is positively correlated with thrombosis and inflammatory SASP factor production. Together, these data indicate F3 links inflammation, thrombosis, and senescence during infection, and propose F3 as a target protein for antiviral treatment.
Increasing Socially Appropriate Behavior for Individuals with Autism Spectrum Disorder Using Functional Communication Training
Authors: Alakhzami Maryam , Chitiyo Morgan 
Published: August 2022

Abstract
Communication deficits are one of the main characteristics of autism spectrum disorder (ASD). Self-injurious behavior (SIB) in individuals with ASDs often occurs due to the individuals’ lack of social-communicative abilities to express what they want (e.g., attention; access to tangible items; help). Many researchers have successfully used functional communication training (FCT) to replace SIB with positive communicative responses for children with ASD. While these studies have reported positive outcomes, there is limited research examining the extent to which the individuals will maintain the gains of the treatment after treatment is discontinued. Thus, this study aimed to investigate the impacts of FCT on socially appropriate behavior of children with ASD and the extent to which the gains would be maintained after withdrawal of treatment. FCT procedures were implemented to increase functional communication responses by asking for a break while limiting SIBs expressed by the participants when confronted with non-preferred activities (e.g., academic tasks). This study revealed that combining FCT with concurrent schedules instead of extinction effectively maintained low rates of SIBs while simultaneously increasing the opportunity for participants to emit alternative communicative responses over time.
Modeling and nonlinear dynamics of a dielectric elastomer soft sandwich cantilever plate
Authors: Xu Jie , Yuan Xue Gang , Wang Yan Qing 
Published: August 2022

Abstract
Inspired from the bimorph actuator which is an efficient design to flap and propel swimming vehicles, a soft actuator made of two dielectric elastomer layers and a hyperelastic material core is presented. This actuator is also termed as a soft sandwich cantilever rectangular plate, which is stimulated by the alternating voltages with a phase difference. Based on the classical plate theory and the variational method, the governing equation describing the nonlinear vibration of the soft sandwich cantilever plate is formulated. Employing the harmonic balance method and the arc-length continuation method, periodic solutions are obtained, then the convergence analyses of the numbers of discrete modes and harmonics are conducted. In order to illustrate the frequency features more clearly, a modified mode numbering scheme is developed. The numerical results manifest that, there are abundant nonlinear behaviors among mode responses of the soft sandwich cantilever plate driven by the combined voltage excitation, including the local peak and the isolated bubble aroused by the nonlinear coupling. Additionally, the fundamental mode response keeps dominating the dynamic behaviors of the soft plate. The nonlinear dynamics broaden the resonant domain significantly, which can be potentially applied to the design and manufacture of high-performance soft actuators through the vibration enhancement strategy.
Climate and earthquake patterns linked through variations in Pacific Ocean sea-level.
Authors: Stone Roger , Mori Jim , Marcussen Torben , Muller R Dietmar , Everingham Yvette , Allan Rob , Pudmenzky Christa 
Published: August 2022

Abstract
The El Niño-Southern Oscillation (ENSO) produces large shifts in ocean and atmospheric conditions in the Pacific and Indian Ocean basins, including major changes in sea level in equatorial regions across the Pacific basin, including the Pacific Rim1-6, 18. The Pacific Ocean rim is also well known as a region prone to a high frequency of earthquakes16,17, which has a profound influence on lives, economies, and ecosystems in the region. An ability to better estimate earthquake risk frequency would be of enormous value in preparedness and response planning16. Here we show that ENSO-driven sea-level variability, measured in the equatorial, northern or overall Pacific Ocean is coherent with subsequent variability in earthquake frequency in the western Pacific Ocean Basin. While the statistical link is evident for M4.7 to M5.5 and ≥M6.5 earthquakes, it is strongest for M4.7 to M5.5 earthquakes. We hypothesize that the relationship is due to a systematic influence of the climate-ocean system on the lithospheric stress field and plate coupling along subduction zones. We suggest these results would underpin an ability to better assess earthquake frequency risk in and around the western Pacific several months in advance.
Achillea santolina and Raphanus sativus extracts downregulated the expression of the developmental genes NOTCH1, SIX1 and WNT1 in colon and breast cancer cell lines.
Authors: Gaafar Reda Mohamed , Mohasseb Reham Nagy , Abd-Elbaseer Mohamed Ali , Salem Mohamed Labib 
Published: August 2022

Abstract
Background: Although anticancer treatment with chemotherapy is an effective approach, the development of cancer stem cells is regulated by several genes, including NOTCH1, SIX1, and WNT1. Sowe have recently found that treatment of Caco2, HepG2 and MCF-7 cell lines with Achillea santolina or Raphanus sativus extracts revealed an antitumor effect. In this study, we aimed to evaluate the effect of these natural extracts on the expression of genes NOTCH1, SIX1 and WNT1 in Caco2 and MCF-7 cell lines. Methods & Results: Colon adenocarcinoma (Caco2), breast cancer (MCF-7) and normal amniotic cell line (WISH) were treated with 110 IC50 concentrations of Achillea santolina and Raphanus sativus extracts and compared to the 110 IC50 concentration of cisplatin as a reference chemotherapy drug. After 72 hours of treatment, total RNA was extracted and then cDNA was prepared for reverse transcriptase PCR of NOCH1, WNT1, and SIX1. The R. sativus treatment significantly decreased NOTCH1 expression in MCF7 and Caco2 cell lines, while it decreased SIX1 gene expression in Caco2 cell lines and WNT1 in MCF7 cell lines. On the other hand, A. santolina extract observably decreased the WNT1 gene expression in the MCF7 cell line. Conclusion: The crude extract of R. sativus decreased the developmental gene expression of NOTCH1, SIX1 in Caco2 cell lines as well as on NOTCH1 and WNT1 in MCF7 cell lines more than cisplatin chemotherapy. Similarly, the A. santolina crude extract decreases the expression of WNT1 in the MCF7 cell line more than cisplatin chemotherapy.
­QTL analysis for nitrogen use efficiency in wheat (Triticum aestivum L.)
Authors: Singh Rakhi , Saripalli Gautam , Kumar Anuj , Gautam Tinku , Singh Susheel Kumar , Gahlaut Vijay , Kumar Sachin , Meher Prabina Kumar , Mishra Rajendra Prasad , Singh Vinod Kumar , Sharma Pradeep Kumar , Balyan Harindra Singh , Gupta Pushpendra Kumar 
Published: August 2022

Abstract
The genetic architecture of nitrogen use efficiency (NUE) and its two component traits i.e. NUpE (N uptake efficiency) and NUtE (N utilization efficiency) was studied using a bi-parental RIL mapping population derived from a cross HUW468 (high NUE)/C306 (low NUE). The mapping population, two parental genotypes and three check genotypes were evaluated under four different N levels (0, 60, 120, and 180 kg/ha) over three years. A genetic map containing 456 SNP markers (2,571.38 cM length) was used for QTL analysis. Thirty six main effect QTLs (17 QTLs for NUE, 13 NUpE and 6QTLs for NUtE) distributed on 12 chromosomes (1B, 1D, 2A, 2B, 3A, 4B, 5A, 5B, 5D, 6A, 6D, and 7A) were identified at 2.52 to 9.27 LOD scores. Individual QTLs explained 6.65–22.89% phenotypic variation. Multi-traits QTLs (Mt-QTLs) and and epistatic QTLs involving first order epistatic (QTL x QTL) interactions were also discovered. Candidate genes (CGs, as many as 737) were mined from QTL regions which were mainly involved in metabolic process, cellular process and catalytic activity, etc; differential expression was observed for 49 genes in roots and 34 CGs in shoots. The CGs encoded important transcription factors, transporters etc. having a role in NUE. QTLs and CGs reported in this study enriched the available knowledge. Seven QTLs (including three Mt-QTLs) and QTLs involved in six epistatic interactions were recommended for MAS for improvement of NUE in wheat.