bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Mitoxantrone Hydrochloride Injection for Tracing Axillary Sentinel Nodes in Breast Cancer: A Self-Controlled Clinical Trial
Authors: Jiao Dechuang , Yang Benlong , Chen Jiajian , Wang Chunjian , Jin Lidan , Zhao Wenhe , Gao Xueqiang , Wang Haibo , Li Jun , Zhao Haidong , Wu Di , Fan Zhimin , Wang Shujun , Liu Zhenzhen , Wang Yongsheng , Wu Jiong 
Published: June 2022

BackgroundMitoxantrone hydrochloride injection for tracing (MHI), a new strategy to identify lymph nodes, has not been tested for axillary node staging in breast cancer. This multicenter, self-controlled, non-inferiority trial aimed to evaluate MHI’s efficacy and safety in sentinel lymph node biopsy (SLNB).MethodsThe trial was conducted across seven hospitals from December 2019 to December 2020. Patients with early-stage breast cancer received MHI and technetium-99m (99mTc) during the surgery. Sentinel node detection rates were compared between MHI and 99mTc to evaluate non-inferiority and concordance. Non-inferiority was valid if the lower limit of the 95% CI of sentinel node relative detection rate difference was ≥−5%.ResultsSLN relative detection rate of MHI was 97.31% (362/372). Of the SLNs, 79.69% (871/1093) were co-detected by both tracers. Of the patients, 4.13% (16/387) had adverse events and recovered during the follow-up.ConclusionsMHI is a lymphatic tracer with comparable efficacy to radionuclides and can be used alone or in combination with radioactive substances for SLNB.Clinical Trial Registrationhttp://www.chinadrugtrials.org.cn, CTR20192435.
Transcriptomics and Network Pharmacology Reveal the Protective Effect of Chaiqin Chengqi Decoction on Obesity-Related Alcohol-Induced Acute Pancreatitis via Oxidative Stress and PI3K/Akt Signaling Pathway
Authors: Yang Xinmin , Yao Linbo , Yuan Mei , Zhang Xiaoying , Jakubowska Monika A. , Ferdek Pawel E. , Dai Lei , Yang Jingyu , Jin Tao , Deng Lihui , Fu Xianghui , Du Dan , Liu Tingting , Criddle David N. , Sutton Robert , Huang Wei , Xia Qing 
Published: June 2022

Obesity-related acute pancreatitis (AP) is characterized by increasing prevalence worldwide and worse clinical outcomes compared to AP of other etiologies. Chaiqin chengqi decoction (CQCQD), a Chinese herbal formula, has long been used for the clinical management of AP but its therapeutic actions and the underlying mechanisms have not been fully elucidated. This study has investigated the pharmacological mechanisms of CQCQD in a novel mouse model of obesity-related alcohol-induced AP (OA-AP). The mouse OA-AP model was induced by a high-fat diet for 12 weeks and subsequently two intraperitoneal injections of ethanol, CQCQD was administered 2 h after the first injection of ethanol. The severity of OA-AP was assessed and correlated with changes in transcriptomic profiles and network pharmacology in the pancreatic and adipose tissues, and further docking analysis modeled the interactions between compounds of CQCQD and their key targets. The results showed that CQCQD significantly reduced pancreatic necrosis, alleviated systemic inflammation, and decreased the parameters associated with multi-organ dysfunction. Transcriptomics and network pharmacology analysis, as well as further experimental validation, have shown that CQCQD induced Nrf2/HO-1 antioxidant protein response and decreased Akt phosphorylation in the pancreatic and adipose tissues. In vitro, CQCQD protected freshly isolated pancreatic acinar cells from H2O2-elicited oxidative stress and necrotic cell death. The docking results of AKT1 and the active compounds related to AKT1 in CQCQD showed high binding affinity. In conclusion, CQCQD ameliorates the severity of OA-AP by activating of the antioxidant protein response and down-regulating of the PI3K/Akt signaling pathway in the pancreas and visceral adipose tissue.
Shema Oral Liquid Ameliorates the Severity of LPS-Induced COPD via Regulating DNMT1
Authors: Zhang Fangbo , Guo Feifei , Liu Yang , Zhang Yi , Li Defeng , Yang Hongjun 
Published: June 2022

Background: Chronic obstructive pulmonary disease (COPD) is the most common respiratory disease with high morbidity and mortality. Shema oral liquid (Shema) is a traditional Chinese medicine (TCM) approved for the treatment of respiratory diseases. Clinical applications have shown that Shema has antitussive, expectorant, and anti-asthmatic effects, but its definite efficacy to COPD is still unclear. This study aimed to explore the therapeutic capacity and potential mechanism of Shema in treatment of COPD.Methods: Network pharmacology was used to investigated the possible pharmacological mechanism of Shema against COPD. A rat model of lipopolysaccharide (LPS)-induced COPD was established to determine pulmonary ventilatory function, serum inflammatory cytokines, and pulmonary pathological change. Subsequently, tandem mass tag (TMT)-based quantitative proteomics was used to further reveal the therapeutic targets related with Shema against COPD. Western blot was finally performed to validate the expression of targeted proteins screened by proteomics research.Results: Network pharmacology analysis indicated that Shema against COPD mainly inhibited the inflammation and affected the immune system. The animal experiment demonstrated that Shema treatment protected the lung tissue from LPS induced injury, inhibited the levels of serum inflammatory cytokines such as interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α, and improved the respiratory ventilatory function by upregulating forced expiratory volume in 0.1 s (FEV0.1), FEV0.3, forced vital capacity (FVC), and the ratios of FEV0.1 (0.3)/FVC. Proteomic analysis and western blot both proved that Shema inhibited the expression of DNA methyltransferase 1 (DNMT1) in the lung tissue.Conclusion: The therapeutic mechanism of Shema in treatment of COPD may involve inhibiting inflammatory response, improving pulmonary ventilatory function, and alleviating LPS-induced lung injury through regulating the expression of DNMT1. This study also shed light on the development of therapeutic strategies in treating COPD by intervening DNMT-related pathways.
Valuing the “Burden” and Impact of Rare Diseases: A Scoping Review
Authors: Delaye Julien , Cacciatore Pasquale , Kole Anna 
Published: June 2022

Introduction: Rare diseases (RDs) are a severe, chronic, degenerative and often life-threatening group of conditions affecting more than 30 million people in Europe. Their impact is often underreported and ranges from psychological and physical symptoms seriously compromising quality of life. There is then a need to consolidate knowledge on the economic, social, and quality of life impacts of rare diseases.Methods: This scoping review is the result of 9 qualitative interviews with experts and a literature search on Cost-of-Illness (COI) studies and quality of life (QoL) studies following the PRISMA methodology. Grey literature was also included to complement findings. Results. 63 COI studies were retrieved, covering 42 diseases and a vast majority of them using a prevalence-based approach (94%). All studies included medical costs, while 60% included non-medical costs, 68% productivity losses and 43% informal care costs. 56 studies on QoL were retrieved, mostly from Europe, with 30 different measurement tools. Grey literature included surveys from the pharmaceutical industry and patient organisations.Discussion: The majority of studies evaluating the impact of RDs on the individual and society use the COI approach, mostly from a societal perspective. Studies often vary in scope, making them difficult to consolidate or compare results. While medical costs and productivity losses are consistently included, QoL aspects are rarely considered in COI and are usually measured through generic tools.Conclusion: A comprehensive study on impact of rare disease across countries in Europe is lacking. Existing studies are heterogeneous in their scope and methodology and often lack a holistic picture of the impact of rare. Consensus on standards and methodology across countries and diseases is then needed. Studies that consider a holistic approach are often conducted by pharmaceutical companies and patient organisations exploring a specific disease area but are not necessarily visible in the literature and could benefit from the sharing of standards and best practices.
Access to Cleaning Services Alters Fish Physiology Under Parasite Infection and Ocean Acidification
Authors: Paula José Ricardo , Repolho Tiago , Grutter Alexandra S. , Rosa Rui 
Published: June 2022

Cleaning symbioses are key mutualistic interactions where cleaners remove ectoparasites and tissues from client fishes. Such interactions elicit beneficial effects on clients’ ecophysiology, with cascading effects on fish diversity and abundance. Ocean acidification (OA), resulting from increasing CO2 concentrations, can affect the behavior of cleaner fishes making them less motivated to inspect their clients. This is especially important as gnathiid fish ectoparasites are tolerant to ocean acidification. Here, we investigated how access to cleaning services, performed by the cleaner wrasse Labroides dimidiatus, affect individual client’s (damselfish, Pomacentrus amboinensis) aerobic metabolism in response to both experimental parasite infection and OA. Access to cleaning services was modulated using a long-term removal experiment where cleaner wrasses were consistently removed from patch reefs around Lizard Island (Australia) for 17 years or left undisturbed. Only damselfish with access to cleaning stations had a negative metabolic response to parasite infection (maximum metabolic rate—ṀO2Max; and both factorial and absolute aerobic scope). Moreover, after an acclimation period of 10 days to high CO2 (∼1,000 µatm CO2), the fish showed a decrease in factorial aerobic scope, being the lowest in fish without the access to cleaners. We propose that stronger positive selection for parasite tolerance might be present in reef fishes without the access to cleaners, but this might come at a cost, as readiness to deal with parasites can impact their response to other stressors, such as OA.
Characterizing Risk of In-Hospital Mortality Following Subarachnoid Hemorrhage Using Machine Learning: A Retrospective Study
Authors: Deng Jiewen , He Zhaohui 
Published: June 2022

BackgroundSubarachnoid hemorrhage has a high rate of disability and mortality, and the ability to use existing disease severity scores to estimate the risk of adverse outcomes is limited. Collect relevant information of patients during hospitalization to develop more accurate risk prediction models, using logistic regression (LR) and machine learning (ML) technologies, combined with biochemical information.MethodsPatient-level data were extracted from MIMIC-IV data. The primary outcome was in-hospital mortality. The models were trained and tested on a data set (ratio 70:30) including age and key past medical history. The recursive feature elimination (RFE) algorithm was used to screen the characteristic variables; then, the ML algorithm was used to analyze and establish the prediction model, and the validation set was used to further verify the effectiveness of the model.ResultOf the 1,787 patients included in the mimic database, a total of 379 died during hospitalization. Recursive feature abstraction (RFE) selected 20 variables. After simplification, we determined 10 features, including the Glasgow coma score (GCS), glucose, sodium, chloride, SPO2, bicarbonate, temperature, white blood cell (WBC), heparin use, and sepsis-related organ failure assessment (SOFA) score. The validation set and Delong test showed that the simplified RF model has a high AUC of 0.949, which is not significantly different from the best model. Furthermore, in the DCA curve, the simplified GBM model has relatively higher net benefits. In the subgroup analysis of non-traumatic subarachnoid hemorrhage, the simplified GBM model has a high AUC of 0.955 and relatively higher net benefits.ConclusionsML approaches significantly enhance predictive discrimination for mortality following subarachnoid hemorrhage compared to existing illness severity scores and LR. The discriminative ability of these ML models requires validation in external cohorts to establish generalizability.
Modified Laparoscopic Nephron-Sparing Surgery for Large Renal Hilar Angiomyolipoma: Dual-Center Experience
Authors: Yang ZeSong , Wang Fang , Lin Deng , Li Qiuyan , Hong Yun , Hu Minxiong , Zhang Dahong , Ye Liefu 
Published: June 2022

ObjectiveThe aim of this study is to evaluate a potential successful strategy for treating large renal hilar angiomyolipoma (RHAML) during the procedure of laparoscopic nephron-sparing surgery (NSS).MethodsThe total study population includes 12 patients with large RHAMLs who underwent laparoscopic NSS in the Department of Urology of Fujian Provincial hospital and People’s Hospital of Zhejiang, ranging from January 2016 to March 2020. The perioperative variables, intraoperative procedures, and postprocedure complications were all recorded. Three months later, all patients returned to the hospital to check their postoperative recovery by reviewing the computed tomography urography (CTU) image. In the follow-up, patients were asked to have their review by CT or color doppler ultrasound every year.ResultsLaparoscopic NSS was successfully performed in all patients. The average operation time was 113.33 ± 33.39 min; the intraoperative blood loss was about 137.50 ± 91.17 ml; the warm ischemia time was 25.25 ± 4.88 min; the drainage tube extubation time was 4.58 ± 2.07 days; and the hospital stay time was 6.42 ± 1.78 days. The average follow-up time was 14.58 ± 9.18 months. After 3 months, all CTU images showed an unobstructed urinary tract in the patient, and no tumor recurrence was found. In addition, no patients had renal atrophy and urine extravasation during follow-up.ConclusionsLaparoscopic NSS for RHAML is complex and technically demanding, but good surgical design and operation can achieve satisfactory surgical results. Modified laparoscopic NSS was a beneficial technique and may provide a reference for treating patients with RHAML.
ВОЛОНТЕРСТВО ЯК СОЦІАЛЬНО-ПЕДАГОГІЧНИЙ ФЕНОМЕН: ТЕРМІНОЛОГІЧНИЙ АНАЛІЗ
Authors: Поліщук Наталія 
Published: June 2022

У статті здійснено термінологічний аналіз волонтерства, волонтерської діяльності як соціально-педагогічного феномену. Здійснений поняттєво-термінологічний аналіз свідчить про відсутність серед науковців єдиного підходу до визначення поняття «волонтер», «волонтерство», «волонтерська діяльність», «волонтерська організація».
Автором потрактовано волонтерську діяльність як соціально-педагогічний феномен, ефективний засіб соціалізації, соціального становлення особистості, студентської молоді як окремої соціально-демографічної групи суспільства, що вирізняється за сукупністю вікових та психофізіологічних особливостей, від рівня здоров’я якої залежить не лише якість їхнього власного життя, а й якість майбутньої професійної діяльності. Виокремлено основні риси волонтера, шляхи проведення волонтерської діяльності, основні напрями роботи студентських волонтерських груп відповідно до мети та основних завдань соціально-педагогічної діяльності окремої державної чи неурядової організації.
Studi Sarana Prasarana Keselamatan Dan Keamanan Wisatawan Pada Destinasi Wisata Pantai Parangtritis Dan Pantai Baron Tahun 2021
Authors: Arianto Machfudz Eko , Saptadi Julian Dwi , Rifai Muchamad 
Published: June 2022

Pengunjung wisata pantai selalu mengalami peningkatan setiap tahun. Peningkatan tersebut menyebabkan pemerintah terus meningkatkan sarana dan prasarana, seperti meningkatkan kualitas jalan raya, sarana prasarana keselamatan dan keamanan aktivitas laut serta keadaan darurat. Pantai Parangtritis dan Pantai Baron merupakan destinasi wisata yang sangat populer di Yogyakarta, aktivitas yang dapat dinikmati yaitu berenang dan aneka jasa wisata. Aktivitas ditempat wisata mempunyai risiko bahaya bagi wisatawan yang dapat berdampak pada keselamatan dan keamanan. Untuk itu perlu didukung dengan sarana prasarana yang menunjang keselamatan dan keamanan pada destinasi wisata tersebut agar risiko yang ada dapat diminimalisir. Tujuan penelitian untuk mengetahui kesesuaian sarana prasarana keselamatan dan keamanan wisatawan pada destinasi wisata Pantai Parangtritis dan Pantai Baron dengan pedoman acuan. Penelitian ini menggunakan metode deskriptif dengan jenis penelitian kualitatif sedangkan untuk metode pengumpulan data di lakukan dengan observasi dan wawancara pada pengelola. Instrumen penelitian ini adalah peneliti sendiri dengan menggunakan bantuan lembar observasi lapangan. Terdapat 4 pedoman acuan yang digunakan yaitu UU No. 22 Tahun 2009 Tentang Lalu Lintas, Australian Coastal Public Safety Guidelines 2007 tentang keselamatan pantai, Pedoman Perencanaan Jalur dan Rambu Evakuasi Tsunami BNPB 2014, serta pedoman Asosiasi Toilet Indonesia 2016. Hasil penelitian yaitu: Sarana prasarana keselamatan lalu lintas wisata pantai Parangtrtis dan Pantai Baron telah sesuai dengan UU No. 22 Tahun 2009 Tentang Lalu Lintas, namun beberapa masih perlu perbaikan. Sarana prasarana keselamatan dan keamanan Pantai Parangtrtis dan Pantai Baron telah sesuai dengan pedoman Australian Coastal Public Safety Guidelines 2007, kecuali warna seragam, bendera keselamatan pantai, pelampung pembatas, dan tas pinggang P3K. Kemudian sarana prasarana keselamatan bencana tsunami di Pantai Parangtritis dan Pantai Baron telah sesuai dengan standar Pedoman Perencanaan Jalur dan Rambu Evakuasi Tsunami BNPB 2014. Sarana prasarana fasilitas umum toilet di Pantai Parangtritis dan Pantai Baron telah sesuai dengan Standar Asosiasi Toilet Indonesia 2016.
Longitudinal maturation of resting state networks: Relevance to sustained attention and attention deficit/hyperactivity disorder
Authors: Thomson Phoebe , Malpas Charles B. , Vijayakumar Nandita , Johnson Katherine A. , Anderson Vicki , Efron Daryl , Hazell Philip , Silk Timothy J. 
Published: June 2022

AbstractThe transition from childhood to adolescence involves important neural function, cognition, and behavior changes. However, the links between maturing brain function and sustained attention over this period could be better understood. This study examined typical changes in network functional connectivity over childhood to adolescence, developmental differences in attention deficit/hyperactivity disorder (ADHD), and how functional connectivity might underpin variability in sustained attention development in a longitudinal sample. A total of 398 resting state scans were collected from 173 children and adolescents (88 ADHD, 85 control) at up to three timepoints across ages 9-14 years. The effects of age, sex, and diagnostic group on changes in network functional connectivity were assessed, followed by relationships between functional connectivity and sustained attention development using linear mixed effects modelling. The ADHD group displayed greater decreases in functional connectivity between salience and visual networks compared with controls. Lower childhood functional connectivity between the frontoparietal and several brain networks was associated with more rapid sustained attention development, whereas frontoparietal to dorsal attention network connectivity related to attention trajectories in children with ADHD alone. Brain network segregation may increase into adolescence as predicted by key developmental theories; however, participants with ADHD demonstrated altered developmental trajectories between salience and visual networks. The segregation of the frontoparietal network from other brain networks may be a mechanism supporting sustained attention development. Frontoparietal to dorsal attention connectivity can be a focus for further work in ADHD.
Great Freedom, Große Freiheit (2021) de Sebastian Meise
Authors: Floch Martine 
Published: June 2022

Le film de fiction du réalisateur autrichien Sebastian Meise thématise la question de la répression de l’homosexualité dans la RFA de l’après-guerre et fait un retour sur l’article 175, renforcé sous la dictature nazie et maintenu tel quel en Allemagne après 1945.
Transparence des finances locales en Algérie
Authors: Ferroukhi Amine 
Published: June 2022

De nos jours, le portail numérique représente la principale source d’information, permettant aux citoyens de suivre une organisation élective. Le présent papier tente d’analyser la transparence des finances locales en Algérie, à travers l’exploration des portails officiels. Une analyse des contenus numériques, partagés sur 39 portails des administrations locales, départements – Wilayas – et municipalités situées au chef-lieu de département, est menée entre le 01 et 19 juin 2021, dans l’objectif d’établir un diagnostic de la transparence des finances locales. L’étude s’est focalisée sur deux principaux domaines, la passation de marchés publics et le processus du budget local. L’analyse des résultats démontre les faiblesses des administrations locales, en matière d’appropriation des outils numériques dans l’information des citoyens, une situation caractérisée par une quasi-absence de la transparence des finances locales.
Planification nationale en Tunisie : Une analyse diachronique
Authors: Taghouti Ibtissem , Elloumi Mohamed , Hinojosa Leonith , Napoléone Claude 
Published: June 2022

La situation de la planification en Tunisie est celle d’un pays qui a, à la fois, une forte tradition historique de planification nationale et qui a montré une grande capacité à évoluer dans ses modes d’organisation : d’institutions centralisées de type socialiste à des plans nationaux de développement libéraux, jusqu’à des processus post-révolutionnaires basés sur la régionalisation et la participation. En nous reposant sur une analyse diachronique des principaux moments de planification nationale et une lecture attentive des documents contemporains, conjointement à des entretiens auprès des principaux acteurs de la planification actuelle, nous mettons en lumière les éléments qui caractérisent la nouvelle planification nationale du développement en Tunisie, notamment la démocratisation du processus et la prise en compte des stratégies des acteurs de la société civile et des opposants politiques. Nous faisons également une analyse critique de ses limites concernant la difficulté d’adéquation entre budgets alloués et attentes suscitées et la délégitimation induite du processus de planification.
Lectures et influences littéraires chez Dorgelès
Authors: Leducq Alexandre 
Published: June 2022

Montmartrois du temps du Bateau-Lavoir, écrivain-combattant, écrivainvoyageur, reporter sur le front de la Drôle de Guerre, Roland Dorgelès fournit un bel exemple de la méthode dite du « biographisme » chère à Sainte-Beuve : son oeuvre, des Croix de bois à Vacances forcées en passant par Sur la route mandarine , est fortement marquée par les évènements qu’il aura vécus toute sa vie. Néanmoins, s’il revendique l’expérience personnelle comme source de ses écrits, fidèle en cela à l’ incipit de sa Caravane sans chameaux : « Ce n’est pas Hérodote qui a découvert l’Égypte, ni Diodore, ni Marc-Aurèle, ni Strabon. C’est moi ! », l’auteur amiénois, grand lecteur, nourrit ses écrits de nombreuses références littéraires qui font presque partie intégrante de sa personnalité. L’article, adapté d’une conférence donnée dans le cadre du festival « Résonances », organisé par le réseau des Maisons d’écrivains des Hauts-de-France, étudie ces lectures qui façonnent en grande partie l’oeuvre de Roland Dorgelès à travers trois thématiques : les grands absents, les maîtres et les voyageurs.