bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic Plantar Fasciitis: Comparison of Ultrasonic Guided Percutaneous Fasciotomy vs New Technique Combining Fasciotomy with Amniotic Membrane Allograft
Authors: Nakagawa Hirotaka F. , Sung Kyungje , Ashkani-Esfahani Soheil , Waryasz Gregory R. , May Tabitha , Sussman Walter 
Published: November 2022

Category: Basic Sciences/Biologics Introduction/Purpose: Plantar fasciitis is a common condition affecting approximately one in ten people in their lifetime. Treatment is typically conservative and symptoms are self-limiting. Operative treatment is indicated in recalcitrant cases. Minimally-invasive partial plantar fasciotomy can be performed using ultrasound-guided percutaneous techniques and is an attractive alternative to traditional surgery. Methods: A retrospective review was performed on consecutive patients who underwent either an ultrasound-guided fasciotomy or a combined percutaneous fasciotomy with a flowable amniotic matrix allograft. All ultrasound-guided percutaneous fasciotomy procedures were performed using the Tenex TX2 cutting device. Human amniotic allograft consisted of an injection of 0.5 mL of a flowable placental tissue matrix. Outcomes were assessed at short-term (2, 8, and 16 weeks) and long-term follow-up (26 and 52 weeks). Results: Both groups demonstrated a significant reduction in pain from baseline after the respective interventions and demonstrated a high level of patient satisfaction. The only significant difference in the 2 groups was at short-term follow-up in which the percutaneous fasciotomy with the amniotic membrane allograft (n=12) showed a statistically-significant reduction (p<0.05) in pain when compared to the fasciotomy alone group (n=11). There was no difference between the 2 groups at long- term follow-up. Conclusion: Treatment of chronic plantar fasciitis using ultrasound-guided fasciotomy is an attractive alternative to traditional surgery. Ultrasound-guided fasciotomy did improve pain from baseline with high level of patient satisfaction. Furthermore, the combination of percutaneous fasciotomy with a flowable amniotic matrix allograft may provide a greater reduction in pain earlier in the post-operative period, but does not seem to alter the long-term outcome of the procedure. More subjects are needed to possibly detect long-term effects.
Minimally Invasive Chevron Akin: Locking the Metatarsal-Cuneiform Joint
Authors: Nunes Gustavo A. , Carvalho Kepler , Ferraz Gabriel F. , Baumfeld Daniel , Baumfeld Tiago S. , Filho Miguel V. Pereira 
Published: November 2022

Category: Bunion Introduction/Purpose: Minimally Invasive Chevron Akin (MICA) can be used to treat hallux valgus (HV) associated with a hypermobility of the first metatarsal-cuneiform joint (1MTCJ). The aim of this study was to perform a radiographic analysis of the MICA, focused on evaluating the 1MTCJ. Methods: Forty patients (50 feet) with moderate to severe HV underwent a MICA procedure. Radiographic analysis included hallux valgus angle (HVA), intermetatarsal angles between the first and second rays (IMA), the intermetatarsal angle between the proximal fragment of the osteotomy and the second ray (IAPF) and the distance between a point 3 cm distal from the base of the second metatarsal and a point located at the same height for the first metatarsal base (Dist 1-2). The IAPF was compared with the preoperative IMA and the other parameters were compared pre and post-operatively. The radiographic complications were also recorded Results: The majority of patients were female (92%). The mean age was 50.4 years (SD =16.1) and the mean follow-up was 16.1 months (SD = 3.5). The average HVA improved from 32.5 to 7.3 degrees and the average IMA from 14.2 to 4.2 degrees. The IAPF and Dist1-2 values showed an increase of 4.8 and 3.2mm respectively. There were no radiographic complications Conclusion: Minimally Invasive Chevron Akin: Locking the Metatarsal-Cuneiform Joint.
Prospective Study of the Inversion Destabilization Maneuver in the Treatment of Acute Ankle Ligament Injury: Case Series
Authors: Oliveira Danilo A. , Mansur Nacime SB 
Published: November 2022

Category: Ankle; Sports; Trauma Introduction/Purpose: Ankle sprains are highly prevalent injuries in athletes whether they are amateurs or professionals. It is estimated that around 5,000 sprains occur a day in the UK, while American data point to around 23,000 cases daily (1/10,000 individuals). The world literature has pointed out that about 7 - 10% of orthopedic visits in an emergency service are due to ankle sprains, corresponding to about 25% of all musculoskeletal injuries. The objective of this paper is to present the clinical results obtained from the prospective observation of a series of patients with lateral ankle sprains treated by the destabilization technique in Inversion of the ankle added to the conventional treatment. Methods: Design Case series, prospective, single center location. The study will be carried out at Hospital São Paulo - University Hospital of UNIFESP (HSP-UNIFESP), at the Orthopedics Outpatient Clinic of the Department of Orthopedics and Traumatology (DOT)/EPM-UNIFESP. Inclusion criteria - Over 18 years of age of both sexes; - Complaint of ankle sprain up to 48 hours - Complete or partial injury to any of the ligaments of the lateral ankle complex; - Isolated or associated ligament injuries; Non-Inclusion Criteria - Past history of surgery on the affected foot or ankle; - Previous complaint in the ankle region; - Any fracture associated with the sprain or influencing injuries; - Any condition that is a contraindication to the proposed therapies; - Refusal to participate in the study Results: We observed in our series of 100 individuals with lateral ankle sprains 6 new episodes of sprain in a follow-up of 12 month. we did not observe the occurrence of spontaneous ankle sprains in the 6 cases, external causal factors were pointed out by the patients. In 1 case the patient stepped on a squash ball, 1 case the patient had his ankle stepped on during a soccer match, in another case the patient suffered a fall while walking with high heel shoes. We also observed a fall from the stairs, a fall on another player's foot during a volleyball game and in the last case the patient suffered a fall after stepping on a hole in the sidewalk during street racing. Conclusion: Based on the findings of the present study, we concluded that in a 12-month follow-up, the ankle inversion destabilization maneuver proved to be efficient in preventing new episodes of lateral ankle sprain, however, new studies with a longer follow-up time, as well as and in order to compare the maneuver described in the study with techniques already described in the literature and used by physical therapists in their clinical practice should be performed.
Outcomes of PIPA/DIPA with Retrograde Screw Fixation for Correction of Lesser Toe Deformities
Authors: Pitts Charles C. , Hamid Rasikh N. , Irwin Todd A. , Jones Carroll P. 
Published: November 2022

Category: Lesser Toes; Midfoot/Forefoot Introduction/Purpose: Hammertoes and other lesser toe deformities represent extremely common foot problems, affecting nearly one-third of the general population. When surgery is indicated, correction of these deformities has traditionally been described using a PIP arthroplasty technique with a smooth, temporary Kirschner-wire for fixation. This method can produce excellent results, but there are well-described risks including deformity recurrence, secondary deformities, painful nonunion, and pin tract infections. Our goal is to describe a more modern technique that includes preparation and arthrodesis of both the PIP and DIP joints with intramedullary screw fixation. Methods: A retrospective chart review was conducted at one tertiary referral center of patients who underwent correction of lesser toe deformity between 2017 and 2021. Inclusion criteria were patient age greater than 18, use of the PIPA/DIPA technique with screw, and a minimum 10 weeks of follow up with radiographs. Charts were reviewed for patient demographics, comorbidities, preoperative characteristics, and postoperative complications. Our primary outcome variable was deformity correction achieved and maintained at minimum 10 weeks postoperatively based on both chart review and radiographs. Secondary outcomes included hardware failure, infection, vascular complication, screw removal for any reason, nonunion, and amputation. Results: 129 patients and 374 operative toes were identified on chart review and met inclusion criteria. Of these patients, 370 toes (98.9%) maintained deformity correction both clinically and radiographically at 10 weeks and did not undergo revision surgery. 17 toes (4.5%) required screw removal for any reason. 3 toes (0.8%) experienced deep infection, and 1 patient experienced superficial infection that resolved with oral antibiotic treatment. Furthermore, in addition to a concomitant deep infection, one toe experienced vascular compromise and required amputation. There were no symptomatic nonunions, and there were 7 (1.8%) asymptomatic nonunions as seen on radiographs. Conclusion: With respect to previously and classically described methods of lesser toe deformity correction, the PIPA/DIPA technique with a retrograde screw presents an acceptable and safe method for sustained deformity correction.
Evaluating the Association of Anesthesia Type with Postoperative Complications in Patients Undergoing Ankle Fracture Repair
Authors: Quan Theodore , Malyavko Alisa , Ifarraguerri Anna Maria M. , Kim Yumin , Mcdaniel Lea , Manzi Joseph E. , Agarwal Amil R. , Chen Frank , Gu Alex , Tabaie Sean 
Published: November 2022

Category: Ankle Introduction/Purpose: General and neuraxial anesthesia are both successful anesthesia techniques used in many orthopaedic procedures. Neuraxial anesthesia involves local anesthetics placed around the central nervous system (CNS) and spinal anesthesia is a subtype where the anesthetic is injected into intrathecal space. General anesthesia is usually recommended in ambulatory surgeries for its rapid onset of action. However, current literature shows contradicting complication profiles between these two anesthesia types. The purpose of this study was to compare the complications and length of hospital stay between patients who underwent general anesthesia versus neuraxial anesthesia during the repair of ankle fractures. Methods: Patients undergoing open reduction and internal fixation (ORIF) for ankle fracture from 2014 to 2018 were identified in the National Surgical Quality Improvement Program database. Patients were stratified into 2 cohorts: general anesthesia and neuraxial anesthesia. In this analysis, demographics data, comorbidities, and postoperative complications were collected and compared between the two cohorts. Bivariate analyses and multivariable logistical regression were performed. Results: Of 3,585 patients who underwent operative treatment for ankle fracture, 3,315 patients (92.5%) had general anesthesia and 270 (7.5%) had neuraxial anesthesia. Compared to patients who had general anesthesia, those who had neuraxial anesthesia were more likely to be older (58.0 vs 49.6 years old; p<0.001), Caucasian (80.0% vs 71.9%; p=0.001), and have an ASA classification of III (38.1% vs 25.0%; p<0.001). On bivariate analyses, patients who had neuraxial anesthesia were more likely to develop pulmonary complications (p=0.173) or extended length of stay more than 5 days (p=0.342) compared to the general anesthesia group. Following adjustment on multivariate analyses, the neuraxial anesthesia cohort no longer had increased likelihood of pulmonary complications or extended length of stay compared to the general anesthesia group. Conclusion: Prior studies have shown that neuraxial anesthesia methods are as effective as general anesthesia with fewer short- term outcomes. When compared to patients who underwent general anesthesia during ORIF for ankle fracture, neuraxial anesthesia patients experienced no significant increases in postoperative complications or extended length of hospital stay. In terms of the variables we explored in the NSQIP database, healthy ankle fracture patients could also benefit from neuraxial anesthetic methods, and they should be considered for this anesthetic type regardless of their lack of comorbidities that would make them high risk for general anesthesia.
Glaucoma-related malpractice litigation in the United States: A review of the WestLaw database
Authors: Wong Jae-Chiang , Mehran Nikki A , Andriola Mark , Lee Daniel , Myers Jonathan S , Kolomeyer Natasha Nayak 
Published: November 2022

Purpose Gaining understanding of glaucoma-related malpractice litigation may highlight ways to improve patient care and minimize risk of litigation. This study aims to analyze the outcomes and characteristics of glaucoma-related malpractice litigation. Materials and Methods The Westlaw legal database (Thomson Reuters, New York, NY, USA) was used to identify cases regarding ‘malpractice’ AND ‘glaucoma’ or related terms. Cases were analyzed for characteristics such as alleged cause of malpractice, outcome, and demographics. Results The initial search terms yielded 498 results, 107 of which met further inclusion criteria. 38 (36%) were resolved via jury trial. Of these, verdicts in favor of the plaintiff were issued in 14 cases (34%), with median adjusted damages of $702,986. Of all 107 cases in the study reviewed, 65 (61%) resulted in verdicts in favor of the defendant. Ophthalmologists were named as defendants in 85% of the cases (with glaucoma specialists representing 7% of the ophthalmologists); optometrists in 24%. Sixty percent of the cases involved non-surgical treatment. The most common medical reasons for litigation were failure to diagnose (38%), and inappropriate/negligent treatment (36%). The most commonly litigated surgical procedures were cataract surgery (48%) and iridotomy/iridectomy (19%). Conclusion Glaucoma-malpractice litigation has increased, with medical mismanagement alleged in the majority of cases. Defendants are frequently successful in obtaining pre-trial dismissal, but the risk of liability increases in cases going to trial. A minority of cases involved glaucoma specialists. This historical analysis of glaucoma-related malpractice cases might provide perspective and aid physicians seeking to avoid litigation.
Use of L-PRF in the Treatment of Osteomyelitis Associated With Osteopetrosis
Authors: Fares Raissa D. , Ribeiro da Silva Jonathan , de Moraes Sylvio Luiz C. , Homsi Nicolas , Escudeiro Emmanuel P. , Corrêa Caroline Águeda , Maia Julia F. , Pereira Rodrigo dos S. 
Published: November 2022

Osteopetrosis is a disorder characterized by an increase in bone density and a reduction in spinal cord spaces. This change results in a defect in osteoclast function and consequent decrease in bone turnover. One of the possible local bone complications is osteomyelitis, which affects up to 10% of patients with this disorder. Platelet concentrates (L-PRF) have been used in cases of bone defects and areas of tissue necrosis, as it has the characteristic of releasing growth factors after activation. The aim of this paper is to present a clinical case of a patient with mandibular osteopetrosis, who underwent dental implantation and subsequent recurrent osteomyelitis and was treated by partial resection associated with L-PRF bone defect coverage. After 1 year of follow-up, the patient presented definitive soft tissue healing, no exposure of bone tissue or phlogistic signs at the site, and good bone repair on computed tomography scan. The present study demonstrated that the association of L-PRF with resection techniques can be a viable method for the management of patients with difficult to treat osteomyelitis, especially in cases of mandibular osteopetrosis.
Novel variants in GALE cause syndromic macrothrombocytopenia by disrupting glycosylation and thrombopoiesis
Authors: Marín-Quílez Ana , Di Buduo Christian Andrea , Díaz-Ajenjo Lorena , Abbonante Vittorio , Vuelta Elena , Soprano Paolo Maria , Miguel-García Cristina , Santos-Mínguez Sandra , Serramito-Gómez Inmaculada , Ruiz-Sala Pedro , Peñarrubia María Jesús , Pardal Emilia , Hernández-Rivas Jesús María , González-Porras José Ramón , García-Tuñón Ignacio , Benito Rocío , Rivera José , Balduini Alessandra , Bastida José María 
Published: November 2022

Abstract
Glycosylation is recognized as a key process for proper megakaryopoiesis and platelet formation. The enzyme uridine diphosphate (UDP)-galactose-4-epimerase, encoded by GALE, is involved in galactose metabolism and protein glycosylation. Here, we studied 3 patients from 2 unrelated families who showed lifelong severe thrombocytopenia, bleeding diathesis, mental retardation, mitral valve prolapse, and jaundice. Whole-exome sequencing revealed 4 variants that affect GALE, 3 of those previously unreported (Pedigree A, p.Lys78ValfsX32 and p.Thr150Met; Pedigree B, p.Val128Met; and p.Leu223Pro). Platelet phenotype analysis showed giant and/or grey platelets, impaired platelet aggregation, and severely reduced alpha and dense granule secretion. Enzymatic activity of the UDP-galactose-4-epimerase enzyme was severely decreased in all patients. Immunoblotting of platelet lysates revealed reduced GALE protein levels, a significant decrease in N-acetyl-lactosamine (LacNAc), showing a hypoglycosylation pattern, reduced surface expression of gylcoprotein Ibα-IX-V (GPIbα-IX-V) complex and mature β1 integrin, and increased apoptosis. In vitro studies performed with patients-derived megakaryocytes showed normal ploidy and maturation but decreased proplatelet formation because of the impaired glycosylation of the GPIbα and β1 integrin, and reduced externalization to megakaryocyte and platelet membranes. Altered distribution of filamin A and actin and delocalization of the von Willebrand factor were also shown. Overall, this study expands our knowledge of GALE-related thrombocytopenia and emphasizes the critical role of GALE in the physiological glycosylation of key proteins involved in platelet production and function.
Genomic and microenvironmental landscape of stage I follicular lymphoma, compared with stage III/IV
Authors: Los-de Vries G. Tjitske , Stevens Wendy B. C. , van Dijk Erik , Langois-Jacques Carole , Clear Andrew J. , Stathi Phylicia , Roemer Margaretha G. M. , Mendeville Matias , Hijmering Nathalie J. , Sander Birgitta , Rosenwald Andreas , Calaminici Maria , Hoster Eva , Hiddemann Wolfgang , Gaulard Philippe , Salles Gilles , Horn Heike , Klapper Wolfram , Xerri Luc , Burton Catherine , Tooze Reuben M. , Smith Alexandra G. , Buske Christian , Scott David W. , Natkunam Yasodha , Advani Ranjana , Sehn Laurie H. , Raemaekers John , Gribben John , Kimby Eva , Kersten Marie José , Maucort-Boulch Delphine , Ylstra Bauke , de Jong Daphne 
Published: November 2022

Abstract
Although the genomic and immune microenvironmental landscape of follicular lymphoma (FL) has been extensively investigated, little is known about the potential biological differences between stage I and stage III/IV disease. Using next-generation sequencing and immunohistochemistry, 82 FL nodal stage I cases were analyzed and compared with 139 FL stage III/IV nodal cases. Many similarities in mutations, chromosomal copy number aberrations, and microenvironmental cell populations were detected. However, there were also significant differences in microenvironmental and genomic features. CD8+ T cells (P = .02) and STAT6 mutations (false discovery rate [FDR] &lt;0.001) were more frequent in stage I FL. In contrast, programmed cell death protein 1–positive T cells, CD68+/CD163+ macrophages (P &lt; .001), BCL2 translocation (BCL2trl+) (P &lt; .0001), and KMT2D (FDR = 0.003) and CREBBP (FDR = 0.04) mutations were found more frequently in stage III/IV FL. Using clustering, we identified 3 clusters within stage I, and 2 clusters within stage III/IV. The BLC2trl+ stage I cluster was comparable to the BCL2trl+ cluster in stage III/IV. The two BCL2trl– stage I clusters were unique for stage I. One was enriched for CREBBP (95%) and STAT6 (64%) mutations, without BLC6 translocation (BCL6trl), whereas the BCL2trl– stage III/IV cluster contained BCL6trl (64%) with fewer CREBBP (45%) and STAT6 (9%) mutations. The other BCL2trl– stage I cluster was relatively heterogeneous with more copy number aberrations and linker histone mutations. This exploratory study shows that stage I FL is genetically heterogeneous with different underlying oncogenic pathways. Stage I FL BCL2trl– is likely STAT6 driven, whereas BCL2trl– stage III/IV appears to be more BCL6trl driven.
Effect of acetazolamide on pulmonary vascular haemodynamics in patients with COPD going to altitude: a randomised, placebo-controlled, double-blind trial
Authors: Lichtblau Mona , Saxer Stéphanie , Mayer Laura , Sheraliev Ulan , Mademilov Maamed , Furian Michael , Buergin Aline , Schweiwiller Philipp M. , Schneider Simon R. , Tanner Felix C. , Sooronbaev Talant , Bloch Konrad E. , Ulrich Silvia 
Published: November 2022

BackgroundCOPD may predispose to symptomatic pulmonary hypertension at high altitude. We investigated haemodynamic changes in lowlanders with COPD ascending to 3100 m and evaluated whether preventive acetazolamide treatment would attenuate the altitude-induced increase in pulmonary artery pressure (PAP).MethodsIn this randomised, placebo-controlled, double-blind, parallel-group trial, patients with COPD Global Initiative for Chronic Obstructive Lung Disease grades 2–3 who were living <800 m and had peripheral oxygen saturation (SpO2) >92% and arterial carbon dioxide tension <6 kPa were randomised to receive either acetazolamide (125–250 mg·day−1) or placebo capsules, starting 24 h before ascent from 760 m and during a 2-day stay at 3100 m. Echocardiography, pulse oximetry and clinical assessments were performed at 760 m and after the first night at 3100 m. Primary outcome was PAP assessed by tricuspid regurgitation pressure gradient (TRPG).Results112 patients (68% men, mean±sdage 59±8 years, forced expiratory volume in 1 s (FEV1) 61±12% pred,SpO295±2%) were included. Mean±sdTRPG increased from 22±7 to 30±10 mmHg in 54 patients allocated to placebo and from 20±5 to 24±7 mmHg in 58 patients allocated to acetazolamide (both p<0.05) resulting in a mean (95% CI) treatment effect of −5 (−9 to −1) mmHg (p=0.015). In patients assigned to placebo at 760/3100 m, mean±sdSpO2was 95±2%/88±3%; in the acetazolamide group, the respective values were 94±2%/90±3% (both p<0.05), resulting in a treatment effect of +2 (1 to 3)% (p=0.001).ConclusionsIn lowlanders with COPD travelling to 3100 m, preventive acetazolamide treatment attenuated the altitude-induced rise in PAP and improved oxygenation.