bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cascading of all-optical logic gates based on semiconductor laser phase-locking
Authors: Volkova Elena , Chipouline Arkadi 
Published: November 2022

Optical information processing is an essential part of contemporary photonics, and it remains a challenge for researchers around the world. The presented work investigates numerically a maximum number of all-optical logic gates in a cascade. The functionality of the all-optical logic gate is based on the injection locking technique with semiconductor lasers. The possibility of cascading a sequence of AND and OR gates, providing a high-quality final signal, is demonstrated for a planar vertical-cavity surface-emitting laser using the traditional Lang–Kobayashi model. It is shown that the maximum number of cascaded gates is limited to three for repetition rates less than 1 Gbit/s.
Chikungunya virus (CHIKV) seroprevalence in the South Pacific populations of the Cook Islands and Vanuatu with associated environmental and social factors
Authors: Saretzki Charlotte E. B. , Dobler Gerhard , Iro Elisabeth , May Yin , Tou Douglas , Lockington Eteta , Ala Michael , Heussen Nicole , Phiri Bruno S. J. , Küpper Thomas 
Published: November 2022

BackgroundArthropod-borne diseases pose a significant and increasing risk to global health. Given its rapid dissemination, causing large-scale outbreaks with severe human infections and economic loss, the Chikungunya virus (CHIKV) is one of the most important arboviruses worldwide. Despite its significance, the real global impact of CHIKV remains underestimated as outbreak data are often incomplete and based solely on syndromic surveillance. During 2011–2016, the South Pacific Region was severely affected by several CHIKV-epidemics, yet the area is still underrepresented in arboviral research.Methods465 outpatient serum samples collected between 08/2016 and 04/2017 on three islands of the island states Vanuatu (Espiritu Santo) and the Cook Islands (Rarotonga, Aitutaki) were tested for anti-CHIKV specific antibodies using Enzyme-linked immunosorbent Assays.ResultsA total of 30% (Cook Islands) and 8% (Vanuatu) of specimens were found positive for anti-CHIKV specific antibodies with major variations in national and intranational immunity levels. Seroprevalence throughout all age groups was relatively constant. Four potential outbreak-protective factors were identified by comparing the different study settings: presence of Ae. albopictus (in absence of ECSA E1-A226V-mutation CHIKV), as well as low levels of human population densities, residents’ travel activity and tourism.ConclusionThis is the first seroprevalence study focussing on an arboviral disease in the Cook Islands and Vanuatu. It highlights the impact of the 2014/2015 CHIKV epidemic on the Cook Islands population and shows that a notable part of the Vanuatu test population was exposed to CHIKV although no outbreaks were reported. Our findings supplement the knowledge concerning CHIKV epidemics in the South Pacific Region and contribute to a better understanding of virus dissemination, including outbreak modifying factors. This study may support preventive and rapid response measures in affected areas, travel-related risk assessment and infection identification in returning travellers.Trial registrationClinicalTrials.gov Aachen: 051/16_09/05/2016 Cook Islands Ref.: #16-16 Vanuatu Ref.: MOH/DG 10/1/1-GKT/lr.
Association between desire thinking and problematic social media use among a sample of Lebanese adults: The indirect effect of suppression and impulsivity
Authors: Awad Emmanuelle , El Khoury-Malhame Myriam , Yakin Ecem , Hanna Venise , Malaeb Diana , Hallit Souheil , Obeid Sahar 
Published: November 2022

Background
Desire thinking, impulsivity and suppression are psychological variables that are intricately related to behavioral addictions. Bearing in mind the scarcity of data on desire thinking, impulsivity, thought suppression and pathological social media use in developing countries such as Lebanon, with the existing literature suggesting a heightened mental health burden associated with this problematic social media use, it becomes all the more important to elucidate their relationship. Our study aims at investigating the association between desire thinking and problematic social media use specifically, and to further test the effect of impulsivity and thought suppression in mediating the relation between the two distinct facets of desire thinking and problematic social media use.

Methods
A cross-sectional study was carried out between November 2021 and March 2022 using a sample of 414 community-dwelling participants aged above 18 years from all Lebanese districts. The data was collected through an online questionnaire including a section about sociodemographic information, the Desire Thinking Questionnaire (DTQ), Impulsive Behavior Scale (S-UPPS-P), White Bear Suppression Inventory (WBSI) and Social Media Disorder Short Form (SMD). The tests used in the bivariate analysis to assess correlates of SMD were the Student t test to compare two means and the Pearson test to correlate two continuous scores. The PROCESS SPSS Macro version 3.4, model four was used to conduct the mediation analysis.

Results
Desire thinking was shown to correlate with increased social media use. Moreover, we found that suppression and lack of premeditation mediated the association between verbal perseveration and social media use disorder whereas suppression and urgency mediated the association between imaginal prefiguration and social media use disorder.

Conclusion
This study provides new insight on a topic of increasing public health concern. Although understudied to date, suppression and impulsivity differentially mediate the influence of both facets of desire thinking on problematic social media use disorder. The current findings point to the highly pervasive issue of social media use disorder and the need to investigate underlying psychological factors that aggravate it to better profile and support individuals struggling with it.
Effectiveness of education intervention of tuberculosis treatment adherence in Khartoum State: A study protocol for a randomized control trial
Authors: Khamis Khalda Mohamed , Kadir Shahar Hayati , Abdul Manaf Rosliza , Hamdan Hamdan Mustafa 
Published: November 2022

Background
Treatment failure and disease relapse among tuberculosis (TB) patients are commonly caused by non-adherence. It can lead to prolonged infection, increased transmission, drug resistance, and loss of life. Even though the causative microorganism of TB has been identified for more than a century, the disease is still a substantial public health problem worldwide. This research aims to devise, implement, and assess an educational intervention to improve adherence to TB treatment.

Methods and findings
A randomised clinical trial involving 146 Sudanese TB patients will be conducted at the Abu Anga hospital in Khartoum. The participants will be randomly assigned to the intervention and control groups. A 2-hour session will be offered to the intervention group in a one-day TB educational intervention course. The same educational materials will also be provided to the control group after the randomised controlled trial (RCT). Data will be collected at baseline, one month, and four months after the intervention. The primary outcome of interest is TB treatment adherence, while secondary outcomes include quality of life score, tuberculosis knowledge, and health belief domains. Generalised estimating equations (GEE) in SPSS software version 25.0 will be utilised to evaluate the changes over time.

Conclusions
This trial will provide information that could be used in improving TB control strategies to achieve better results in the adherence of healthcare services to the norms of the National Program and patient adherence to the disease treatment and cure.

Trial registration
This study is registered at TCTR: (TCTR20210607006).
The impact of increasing expenditure on National Essential Public Health Services on the medical costs of hypertension in China: A difference-in-difference analysis
Authors: Xue Long , Sui Mengyun , He YunZhen , Li Hongzheng , Ying Xiaohua 
Published: November 2022

Background
The prevention and control of hypertension should be an effective way to reduce deaths and it has been a high priority in China. In 2013, the Chinese government increased the subsidy standard for the National Essential Public Health Services Package (NEPHSP) from RMB 15 to RMB 30 per person, which was expected to cover 70 million hypertensions. This study explored the influence of increasing NEPHSP subsidy on outpatient and inpatient expenditure among patients with hypertension.

Methods
Data were mined from the 2011–2015 Harmonized China Health and Retirement Longitudinal Study. The study sample included 3192 hypertensive patients who were not lost to follow-up from 2011 to 2015. Hypertensive patients who covered by NEPHSP from 2011 to 2015 were defined as the treatment group, otherwise defined as the comparison group. The policy intervention was the increase of NEPHSP subsidy in 2013, and the years before and after 2013 were respectively considered as pre- (2011) and post-intervention (2015). The primary outcomes variables were the outpatient and inpatient expenditure of patients with hypertension, based on direct spending of outpatients and inpatients separately reported by patients with hypertension. Using propensity score matching (PSM) to match the individual characteristics of hypertension in the treatment group and the comparison group, difference-in-differences (DID) were used to analyze the outcomes.

Results
The patients with hypertension’ outpatient and inpatient expenditure patterns in the treatment and control group show an increasing trend from 2011 to 2015. After PSM, of the 1 956 hypertensive participants, 369 covered by the NEPHSP before and after 2013. A DID estimate of the increased NEPHSP subsidy was associated with a significant decrease of 1 251.35 RMB (t = 2.13, P = 0.034) in hypertension related inpatient expenditure, no significant change (t = 0.61, P = 0.544) among outpatient expenditure.

Conclusions
The NEPHSP may reduce inpatient expenditure among hypertension. Further strengthening of the NEPHSP may reduce their burden.
Socioeconomic inequalities in utilizing facility delivery in Bangladesh: A decomposition analysis using nationwide 2017–2018 demographic and health survey data
Authors: Rahman Md. Ashfikur , Kundu Satyajit , Rashid Harun Or , Shanto Hasibul Hasan , Rahman Md. Mahmudur , Khan Bayezid , Howlader Md. Hasan , Islam Md. Akhtarul 
Published: November 2022

Background
In many low- and middle-income countries (LMICs), including Bangladesh, socioeconomic inequalities in access to maternity care remain a substantial public health concern. Due to the paucity of research, we attempted to determine the factors affecting the facility delivery, quantify wealth-related inequality, and identify potential components that could explain the inequality.

Methods
We used the latest Bangladesh Demographic and Health Survey (BDHS 2017–18) data in this study. We utilized logistic regression to investigate the associated factors of facility delivery. The concentration curves (CC), concentration index (CIX) and decomposition of CIX techniques were used to analyze the inequality in-facility delivery.

Results
Women living in the urban areas, age at first birth after (18–24 years ≥25 years), being overweight/obese, having secondary and higher-level education of the women and their husband, seeking four or more ANC, coming from more affluent households, and women with high enlightenment were significant determinants of facility delivery. The concentration curve was below the line of equality, and the relative concentration index (CIX) was 0.205 (p <0.001), indicating that women from wealthy groups were disproportionately more prevalent to facility delivery. The decomposition analysis reveals that wealth status of women (57.40%), age at first birth (10.24%), husband’s education (8.96%), husband’s occupation (7.35%), education of women (7.13%), women’s enlightenment (6.15%), residence (8.64%) and ANC visit (6.84%) are the most major contributors to the inequalities in utilizing facility delivery.

Conclusion
The study demonstrates a clear disparity in the use of facility delivery among Bangladeshi women; hence, immediate action is required to lower the inequalities, with a special emphasis on the contributing factors.
Estado, narcocultura y coreografías sociales del género en México
Authors: Valencia Sayak 
Published: November 2022

Resumen
En el presente trabajo reflexionaré sobre el papel que juega la reconfiguración política, económica, social y cultural a partir de la proliferación de la necropolítica en México contemporáneo y su vinculación con una axiología violenta, neoliberal, racista y cisheteropatriarcal fomentada por el Estado-Nación.1 Axiología encarnada muy visiblemente por la cultura del crimen organizado, especialmente a través de la narcocultura, y difundida por los medios de comunicación y las industrias culturales.
Distinct conformational and energetic features define the specific recognition of (di)aromatic peptide motifs by PEX14
Authors: Gopalswamy Mohanraj , Zheng Chen , Gaussmann Stefan , Kooshapur Hamed , Hambruch Eva , Schliebs Wolfgang , Erdmann Ralf , Antes Iris , Sattler Michael 
Published: November 2022

Abstract
The cycling import receptor PEX5 and its membrane-located binding partner PEX14 are key constituents of the peroxisomal import machinery. Upon recognition of newly synthesized cargo proteins carrying a peroxisomal targeting signal type 1 (PTS1) in the cytosol, the PEX5/cargo complex docks at the peroxisomal membrane by binding to PEX14. The PEX14 N-terminal domain (NTD) recognizes (di)aromatic peptides, mostly corresponding to Wxxx(F/Y)-motifs, with nano-to micromolar affinity. Human PEX5 possesses eight of these conserved motifs distributed within its 320-residue disordered N-terminal region. Here, we combine biophysical (ITC, NMR, CD), biochemical and computational methods to characterize the recognition of these (di)aromatic peptides motifs and identify key features that are recognized by PEX14. Notably, the eight motifs present in human PEX5 exhibit distinct affinities and energetic contributions for the interaction with the PEX14 NTD. Computational docking and analysis of the interactions of the (di)aromatic motifs identify the specific amino acids features that stabilize a helical conformation of the peptide ligands and mediate interactions with PEX14 NTD. We propose a refined consensus motif ExWΦxE(F/Y)Φ for high affinity binding to the PEX14 NTD and discuss conservation of the (di)aromatic peptide recognition by PEX14 in other species.
‘From Where Are These Words?’ The Reception of the Bible in the Babylonian Talmud
Authors: Wolf Sarah 
Published: November 2022

AbstractThis article addresses the paradox of the Bible’s reception in the Babylonian Talmud: that despite the Bible’s centrality to many of the discussions and stories in the Talmud, the Talmud ultimately recontextualizes the Bible by creating a new version of the Jewish study canon. It argues that this paradox cannot be understood without recognizing that there are essentially two different concepts of the Bible held by the late rabbis; that is, a material Bible and a memorized Bible. The Bible makes an appearance in the Talmud as a physical object or set of objects, composed of words on parchment, and consisting of a specific collection of works, which are accorded special status. However, the Bible as a memorized study text plays a different role in Talmudic hermeneutics, in which the redactors of the Talmud present the Bible in atomized form as one of many sources that are all subject to the same type of discussion and interpretation. By analyzing the complexity of the Bible’s role in the Talmud, this article stakes a middle ground between the argument that the Talmud and other works of rabbinic literature are in some fundamental sense part of a continuous line of revision and commentary that dates back to the earliest forms of inner-biblical exegesis; and, on the other hand, the position that the rabbis either are uninterested in or represent an active rupture from modes of reading the Bible.
Model organisms for functional validation in genetic renal disease
Authors: Boettcher Susanne , Simons Matias 
Published: November 2022

Abstract
Functional validation is key for establishing new disease genes in human genetics. Over the years, model organisms have been utilized in a very effective manner to prove causality of genes or genetic variants for a wide variety of diseases. Also in hereditary renal disease, model organisms are very helpful for functional validation of candidate genes and variants identified by next-generation sequencing strategies and for obtaining insights into the pathophysiology. Due to high genetic conservation as well as high anatomical and physiological similarities with the human kidney, almost all genetic kidney diseases can be studied in the mouse. However, mouse work is time consuming and expensive, so there is a need for alternative models. In this review, we will provide an overview of model organisms used in renal research, focusing on mouse, zebrafish, frog, and fruit flies.
Influence of pre- and post-weld heat treats on microstructures of laser welded GTD-111 with IN-718 as filler metal
Authors: Jaruratchataphun Juthamate , Kiatwisarnkij Napat , Rojhirunsakool Tanaporn , Lothongkum Gobboon , Wangyao Panyawat 
Published: November 2022

Abstract
The present research work studied and evaluated conditions of pre-weld and post-weld heat treatments for the laser welding process, aiming to avoid weld cracking, which usually occurs after tungsten inert gas and/or laser welding processes in cast nickel-based superalloys with high aluminum and titanium contents. The pre-weld heat treatment conditions used in the experiments were (1) 1473 K for 7.2 ks, (2) 1433 K for 7.2 ks + 1298 K for 56.7 ks, (3) 1413 K for 7.2 ks + 1298 K for 56.7 ks, (4) 1393 K for 7.2 ks + 1298 K for 56.7 ks. A laser welding process on cast nickel-based superalloys, grade GTD-111, with metal filler of Inconel 718, a nickel-iron based alloy was conducted. From all obtained results, it was found that the pre-weld heat treatment conditions significantly influence microstructures before laser welding. After laser welding and post-weld heat treatment at a temperature of 1473 K for 7.2 ks followed by precipitation aging at a temperature of 1118 K for 86.4 ks (standard heat treatment), all welded specimens exhibited similar microstructures and hardness values. Furthermore, no weld cracking was observed in all welded specimens.
More to Tell About Billa!
Authors: Edmonds Alexander Johannes , Creamer Petra M. 
Published: November 2022

Abstract
Despite being one of the most prominent and best-documented northern client states of the Ur III state, the city of Asimānum/Šimānum remained unlocalized. Here, we demonstrate through both historical-geographical and philological argumentation and archaeological evidence that it must correspond to later Middle and Neo-Assyrian Šibaniba, modern Tell Billa, northern Iraq. Building upon this finding, we propose a new history of Tell Billa during the Early and Middle Bronze Age.
Coupled Dynamics of Stimulus-Evoked Gustatory Cortical and Basolateral Amygdalar Activity
Authors: Mahmood Abuzar , Steindler Jessica , Germaine Hannah , Miller Paul , Katz Donald B. 
Published: November 2022

Gustatory cortical (GC) single-neuron taste responses reflect taste quality and palatability in successive epochs. Ensemble analyses reveal epoch-to-epoch firing-rate changes in these responses to be sudden, coherent transitions. Such nonlinear dynamics suggest that GC is part of a recurrent network, producing these dynamics in concert with other structures. Basolateral amygdala (BLA), which is reciprocally connected to GC and central to hedonic processing, is a strong candidate partner for GC, in that BLA taste responses evolve on the same general clock as GC and because inhibition of activity in the BLA→GC pathway degrades the sharpness of GC transitions. These facts motivate, but do not test, our overarching hypothesis that BLA and GC act as a single, comodulated network during taste processing. Here, we provide just this test of simultaneous (BLA and GC) extracellular taste responses in female rats, probing the multiregional dynamics of activity to directly test whether BLA and GC responses contain coupled dynamics. We show that BLA and GC response magnitudes covary across trials and within single responses, and that changes in BLA–GC local field potential phase coherence are epoch specific. Such classic coherence analyses, however, obscure the most salient facet of BLA–GC coupling: sudden transitions in and out of the epoch known to be involved in driving gaping behavior happen near simultaneously in the two regions, despite huge trial-to-trial variability in transition latencies. This novel form of inter-regional coupling, which we show is easily replicated in model networks, suggests collective processing in a distributed neural network.SIGNIFICANCE STATEMENTThere has been little investigation into real-time communication between brain regions during taste processing, a fact reflecting the dominant belief that taste circuitry is largely feedforward. Here, we perform an in-depth analysis of real-time interactions between GC and BLA in response to passive taste deliveries, using both conventional coherence metrics and a novel methodology that explicitly considers trial-to-trial variability and fast single-trial dynamics in evoked responses. Our results demonstrate that BLA–GC coherence changes as the taste response unfolds, and that BLA and GC specifically couple for the sudden transition into (and out of) the behaviorally relevant neural response epoch, suggesting (although not proving) that: (1) recurrent interactions subserve the function of the dyad as (2) a putative attractor network.