bluuebunny/crossref_metadata_2025_split huggingface dataset:
First‐in‐human study of ONO‐4578, an antagonist of prostaglandin E2 receptor 4, alone and with nivolumab in solid tumors
Authors: Iwasa Satoru , Koyama Takafumi , Nishino Makoto , Kondo Shunsuke , Sudo Kazuki , Yonemori Kan , Yoshida Tatsuya , Tamura Kenji , Shimizu Toshio , Fujiwara Yutaka , Kitano Shigehisa , Shimomura Akihiko , Sato Jun , Yokoyama Fumiharu , Iida Hiroyuki , Kondo Maki , Yamamoto Noboru 
Published: September 2022

AbstractEP4, a prostaglandin E2 receptor, has shown an immunosuppressive activity on cancer cells. This first‐in‐human study evaluated ONO‐4578, a highly selective EP4 antagonist, as monotherapy and in combination with nivolumab in patients with advanced or metastatic solid tumors. A daily dose ranging from 30 mg to 100 mg of ONO‐4578 monotherapy and that ranging from 2 mg to 60 mg of ONO‐4578 with biweekly nivolumab 240 mg were administered. A total of 31 patients were enrolled, 10 receiving monotherapy and 21 receiving combination therapy. Overall, 26 patients experienced treatment‐related adverse events. Dose‐limiting toxicities were observed in three patients; one of six patients receiving 100 mg monotherapy developed grade 3 duodenal ulcer and two of six patients receiving 60 mg combination therapy developed either grade 3 erythema multiforme or grade 3 increased amylase and grade 4 increased lipase. One patient with small‐cell lung cancer who received 40 mg combination therapy had a partial response, and three patients with monotherapy and six patients with combination therapy had stable disease. Pharmacodynamics analyses showed that ONO‐4578 had EP4 antagonistic activity at doses as low as 2 mg. In conclusion, the maximum tolerated dose of ONO‐4578 alone or in combination with nivolumab was not reached. ONO‐4578 was well tolerated at the tested doses and showed signs of antitumor activity. Considering safety, efficacy, and pharmacokinetics/pharmacodynamics results, ONO‐4578 40 mg daily with nivolumab 240 mg biweekly was selected as the recommended dose for future clinical trials. (Registration: JapicCTI‐173,496 and NCT03155061).
The potential role of interleukin (IL)‐25/IL‐33/thymic stromal lymphopoietin (TSLP) on the pathogenesis of idiopathic pulmonary fibrosis
Authors: Xu Xuefeng , Dai Huaping , Zhang Jinglan 
Published: September 2022

AbstractObjectivesInterleukin (IL)‐25, IL‐33, and thymic stromal lymphopoietin (TSLP) are the important drivers for excessive type‐2 immunity. It has been well elucidated that IL‐25/IL‐33/TSLP plays an important role in allergic airway inflammation and remodeling, whereas their roles in idiopathic pulmonary fibrosis (IPF) still remained largely unclear. Herein, the aim of the review is to discuss the potential role and mechanism of IL‐25/IL‐33/TSLP on IPF by literature analysis and summary.Data sourceWe have done a literature search using the following terms: (“idiopathic pulmonary fibrosis” OR “IPF” OR “lung fibrosis”) and (TSLP or “thymic stromal lymphopoietin” or IL‐25 OR IL‐17E OR IL‐33) from the database of PubMed published in English up to July 2018.Study selectionWe have totally found 58 articles by using the retrieval terms mentioned above. By careful title and abstract reading, 10 original research articles of high quality were enrolled for the full text reading and analysis. Two additional relevant studies were also included during the course of literature readings.ResultsIL‐25/IL‐33/TSLP and their corresponding receptors, that is, IL‐17BR/ST2L/TSLPR, are shown to be up‐regulated both in IPF patients and bleomycin (BLM)‐induced lung fibrosis mice model. IL‐25 may promote lung fibrosis by activating IL‐17BR+fibroblast and IL‐17BR+ILC2 (type 2 innate lymphoid cell). Full length (fl)‐IL‐33, as a transcription factor mainly in the cell nucleus, mediated non‐atopic lung inflammation and fibrosis by modulating expressions of several pro‐fibrotic mediators, including transforming growth factor (TGF)‐b1. By contrast, mature (m)‐IL‐33 potentiates lung fibrosis by recruiting ST2L+M2 macrophages and ST2L+ILC2 to enlarge type 2 immunity. TSLP was shown to directly promote CCL2 expression in primary human lung fibroblasts (pHLFs).ConclusionIL‐25/IL‐33/TSLP contributes to non‐allergic lung fibrosis by mediating persistent abnormal epithelial‐mesenchymal crosstalk. IL‐25/IL‐33/TSLP may serve the promising novel target for the treatment of IPF.
Relevance of the College of American Pathologists guideline for validating whole slide imaging for diagnostic purposes to cytopathology
Authors: Antonini Pietro , Santonicco Nicola , Pantanowitz Liron , Girolami Ilaria , Rizzo Paola Chiara , Brunelli Matteo , Bellevicine Claudio , Vigliar Elena , Negri Giovanni , Troncone Giancarlo , Fadda Guido , Parwani Anil , Marletta Stefano , Eccher Albino 
Published: September 2022

AbstractWhole slide imaging (WSI) allows pathologists to view virtual versions of slides on computer monitors. With increasing adoption of digital pathology, laboratories have begun to validate their WSI systems for diagnostic purposes according to reference guidelines. Among these the College of American Pathologists (CAP) guideline includes three strong recommendations (SRs) and nine good practice statements (GPSs). To date, the application of WSI to cytopathology has been beyond the scope of the CAP guideline due to limited evidence. Herein we systematically reviewed the published literature on WSI validation studies in cytology. A systematic search was carried out in PubMed‐MEDLINE and Embase databases up to November 2021 to identify all publications regarding validation of WSI in cytology. Each article was reviewed to determine if SRs and/or GPSs recommended by the CAP guideline were adequately satisfied. Of 3963 retrieved articles, 25 were included. Only 4/25 studies (16%) satisfied all three SRs, with only one publication (1/25, 4%) fulfilling all three SRs and nine GPSs. Lack of a suitable validation dataset was the main missing SR (16/25, 64%) and less than a third of the studies reported intra‐observer variability data (7/25, 28%). Whilst the CAP guideline for WSI validation in clinical practice helped the widespread adoption of digital pathology, more evidence is required to routinely employ WSI for diagnostic purposes in cytopathology practice. More dedicated validation studies satisfying all SRs and/or GPSs recommended by the CAP are needed to help expedite the use of WSI for primary diagnosis in cytopathology.
Un ensayo clínico no ético y la politización de la pandemia de COVID‐19 en Brasil: El caso de Prevent Senior
Authors: Hellmann Fernando , Homedes Núria 
Published: September 2022

ResumenEl Senado Federal de Brasil creó una Comisión Parlamentaria de Investigación (CPI) para investigar las irregularidades del gobierno de Bolsonaro en la gestión de la pandemia de COVID‐19. Uno de los casos que llamó la atención fue la investigación llevada a cabo por Prevent Senior, una empresa privada de seguros de salud, sobre el tratamiento temprano de COVID‐19. Este artículo analiza la validez científica de la investigación y los problemas éticos relacionados con su implementación. Se basa en un análisis del informe del estudio clínico de Prevent Senior, de los registros de ensayos clínicos de Brasil y Estados Unidos, del informe de la CPI del Senado y de información difundida por los medios de comunicación. Este caso de fraude científico y sesgo político‐ideológico ejemplifica cómo Prevent Senior, utilizando un protocolo cuestionable para mejorar su reputación y obtener el apoyo del gobierno, contribuyó a la construcción de la narrativa de “tratamiento temprano” para COVID‐19, y muestra cómo sirvió de base para una política pública del gobierno que promovió el uso de medicamentos ineficaces.
Prevalence, associations and health outcomes of binge eating in adults with type 1 or type 2 diabetes: Results from Diabetes MILES – The Netherlands
Authors: Huisman Sasja D. , Hendrieckx Christel , Bot Mariska , Pouwer François , Nefs Giesje 
Published: September 2022

AbstractAimsTo examine the prevalence and health risks of binge eating in people with diabetes.MethodsSelf‐report data were analysed from a subsample (n = 582 type 1 diabetes/735 type 2 diabetes) of Diabetes MILES – the Netherlands, an online survey. Prevalence of binge eating was compared across diabetes type and treatment and between participants with and without binges for eating styles, diabetes treatment and outcomes, weight, BMI and psychological comorbidity. Associations between binge eating, HbA1c, BMI, diabetes distress were assessed using hierarchical linear regression analyses.Results23% (n = 308) of participants reported eating binges, with 16% at least monthly, and 6% at least weekly. Prevalence and frequency of binges did not differ across diabetes type or treatment. People reporting binges scored higher on dietary restraint, emotional and external eating and reported higher weight and BMI than those without binges. Only people with type 1 diabetes and eating binges had a higher HbA1c.Hierarchical regression analyses demonstrated that binge eating was independently associated with higher HbA1c (β = 0.12, p=0.001), BMI (β = 0.13, p < 0.001) but not with diabetes distress.ConclusionsThis study found binge eating to be associated with eating styles, BMI and HbA1c. However, our cross‐sectional data do not allow for conclusions on causality. Future studies could further examine the directions of these associations and their clinical implications.
Assessing female accountability in the long eighteenth century through debt imprisonment
Authors: Wakelam Alexander 
Published: September 2022

AbstractThis article measures the relationship between marital rates and female economic independence in eighteenth‐century England and Wales through an assessment of their confinement in debtors’ prisons. While an array of scholarship has emphasised the enduring agency of women who were able to continue managing enterprises after marriage, this has arguably too severely diminished the significance of coverture which eradicated the legal identity of wives. By insisting agency requires the ability to be held accountable not merely in terms of the capacity to act, this research emphasises that, until it was abolished, coverture continued to matter in a practical economic sense and not merely in legal theory. As marriage rates increased, the rate at which women were held accountable for their debts declined, suggesting a proportional limitation of their independence, functioning essentially as their husband's employee. Industrialisation had little impact upon female accountability, suggesting that demography rather than capitalism governed how women engaged with the market. Furthermore, this research highlights a striking shift in how women understood their own identity, increasingly adopting occupational rather than marital descriptions of themselves possibly owing to the increased marginality of singlewomen.
An Investigation of the Nature and Consequence of the Relationship between IRT Difficulty and Discrimination
Authors: Sweeney Sandra M. , Sinharay Sandip , Johnson Matthew S. , Steinhauer Eric W. 
Published: September 2022

AbstractThe focus of this paper is on the empirical relationship between item difficulty and item discrimination. Two studies—an empirical investigation and a simulation study—were conducted to examine the association between item difficulty and item discrimination under classical test theory and item response theory (IRT), and the effects of the association on various quantities of interest. Results from the empirical investigation show that item difficulty and item discrimination are negatively correlated under classical test theory, mostly negatively correlated under the two‐parameter logistic model, and mostly positively correlated under the three‐parameter logistic model; the magnitude of the correlation varied over the different data sets. Results from the simulation study reveal that a failure to incorporate the correlation between item difficulty and item discrimination in IRT simulations may provide the investigator with inaccurate values of important quantities of interest, and may lead to incorrect operational decisions. Implications to practice and future directions are discussed.
Justice in supply chain relationships: A comprehensive review and future research directions
Authors: Alghababsheh Mohammad , Gallear David , Saikouk Tarik 
Published: September 2022

AbstractThis paper aims to assess the current status of research on inter‐organisational justice in supply chain relationships (SCRs), analyse its key themes and develop future research directions to advance the knowledge of SCRs. The study employed a rigorous review methodology that combined systematic and snowballing searches. In total, 98 papers published in peer‐reviewed journals between 1983 and 2020 were identified and have been descriptively and thematically analysed. Through synthesising and integrating the extant research, the study develops a taxonomy of types of inter‐organisational justice in SCRs (i.e., relationship overall justice, relationship dimensional‐based justice, event overall justice and event dimensional‐based justice). The review also identifies and discusses three main themes (and subthemes) of the existing research, including antecedents (i.e., governance mechanism, governance design, breach of contract and relationship power), outcomes (i.e., attitudinal, behavioural and performance) and boundary conditions (i.e., relationship and environmental) of inter‐organisational justice in SCRs. The study concludes by identifying current gaps and suggesting important research directions for further work.
Efficacy of rituximab in anti‐myelin‐associated glycoprotein demyelinating polyneuropathy: Clinical, hematological and neurophysiological correlations during 2 years of follow‐up
Authors: Parisi Mattia , Dogliotti Irene , Clerico Michele , Bertuzzo Davide , Benevolo Giulia , Orsucci Lorella , Schiavetti Irene , Cavallo Roberto , Cavallo Federica , Ragaini Simone , Di Liberto Alessandra , Ferrante Martina , Bondielli Giulia , Artusi Carlo Alberto , Drandi Daniela , Lopiano Leonardo , Ferrero Bruno , Ferrero Simone 
Published: September 2022

AbstractBackground and purposeWe evaluated the clinical and neurophysiological efficacy of rituximab (RTX) in a neurophysiologically homogeneous group of patients with monoclonal gammopathy and immunoglobulin M (IgM) anti‐myelin‐associated glycoprotein antibody (anti‐MAG) demyelinating polyneuropathy.MethodsTwenty three anti‐MAG‐positive polyneuropathic patients were prospectively evaluated before and for 2 years after treatment with RTX 375 mg/m2. The Inflammatory Neuropathy Cause and Treatment (INCAT) disability scale (INCAT‐ds), modified INCAT sensory score (mISS), Medical Research Council sum score, Patients’ Global Impression of Change scale were used, IgM levels were assessed and extensive electrophysiological examinations were performed before (T0) and 1 year (T1) and 2 years (T2) after RTX treatment.ResultsAt T1 and T2 there was a significant reduction from T0 both in mISS and in INCAT‐ds, with a p value < 0.001 in the inferential Friedman's test overall analysis. Ulnar nerve Terminal Latency Index and distal motor latency significantly changed from T0 to T1 and in the overall analysis (p = 0.001 and p = 0.002), and ulnar nerve sensory nerve action potential (SNAP) amplitude was significantly increased at T2 from T1, with a p value < 0.001 in the overall analysis. Analysis of the receiver‐operating characteristic curves showed that a 41.8% increase in SNAP amplitude in the ulnar nerve at T2 from T0 was a fair predictor of a mISS reduction of ≥2 points (area under the curve 0.85; p = 0.005; sensitivity: 90.9%, specificity: 83.3%).ConclusionsThis study suggests that RTX is effective in patients with clinically active demyelinating anti‐MAG neuropathy over 2 years of follow‐up, and that some neurophysiological variables might be useful for monitoring this efficacy.
Cross‐scale regulation of seasonal microclimate by vegetation and snow in the Arctic tundra
Authors: von Oppen Jonathan , Assmann Jakob J. , Bjorkman Anne D. , Treier Urs A. , Elberling Bo , Nabe‐Nielsen Jacob , Normand Signe 
Published: September 2022

AbstractClimate warming is inducing widespread vegetation changes in Arctic tundra ecosystems, with the potential to alter carbon and nutrient dynamics between vegetation and soils. Yet, we lack a detailed understanding of how variation in vegetation and topography influences fine‐scale temperatures (“microclimate”) that mediate these dynamics, and at what resolution vegetation needs to be sampled to capture these effects. We monitored microclimate at 90 plots across a tundra landscape in western Greenland. Our stratified random study design covered gradients of topography and vegetation, while nested plots (0.8–100 m2) enabled comparison across different sampling resolutions. We used Bayesian mixed‐effect models to quantify the direct influence of plot‐level topography, moisture and vegetation on soil, near‐surface and canopy‐level temperatures (−6, 2, and 15 cm). During the growing season, colder soils were predicted by shrub cover (−0.24°C per 10% increase), bryophyte cover (−0.35°C per 10% increase), and vegetation height (−0.17°C per 1 cm increase). The same three factors also predicted the magnitude of differences between soil and above‐ground temperatures, indicating warmer soils at low cover/height, but colder soils under closed/taller canopies. These findings were consistent across plot sizes, suggesting that spatial predictions of microclimate may be possible at the operational scales of satellite products. During winter, snow cover (+0.75°C per 10 snow‐covered days) was the key predictor of soil microclimate. Topography and moisture explained little variation in the measured temperatures. Our results not only underline the close connection of vegetation and snow with microclimate in the Arctic tundra but also point to the need for more studies disentangling their complex interplay across tundra environments and seasons. Future shifts in vegetation cover and height will likely mediate the impact of atmospheric warming on the tundra soil environment, with potential implications for below‐ground organisms and ecosystem functioning.
Allure and the spatialities of nationalism, war and development: Towards a geography of beauty
Authors: Faria Caroline V. , Fluri Jennifer L. 
Published: September 2022

AbstractThe work of beauty—in disciplining bodies, imagining nations, driving globalized commodity networks, and fostering booming tourist industries, for example, is a vibrant area of research across the Humanities and Social Sciences. However, an understanding of the complex ideologies, material objects, and practices of beauty remain undeveloped in our field. In this article we call on geographers to take beauty, and its spatialities, seriously. We center the powerful work of beauty in three connected arenas, each of long‐held interest to political geographers: nationalism, militarism, and development. For each we engage analyses of beauty from beyond our discipline. Drawing on our own research and that of a limited, but growing, body of geographers, we point to the instructive openings a feminist geographic approach to beauty, widely imagined but always grounded in power, offers.
A review of social roles in green consumer behaviour
Authors: Xiao Jing , Yang Zhi , Li Zhen , Chen Zhi 
Published: September 2022

AbstractDespite the broad interest and rapid increase in studying green consumer behaviour (GCB) from a social perspective, related articles have been presented in a piecemeal fashion and have lacked a review of social roles in GCB. Additionally, the research focus may differ from the influence of digital technology. Therefore, this study draws on a review of 439 GCB articles that focus on social roles and utilizes both quantitative and qualitative analyses to provide a general picture of theories, social factors, research topics and topic trends with a specific emphasis on the research differences between the traditional and digital contexts. The findings indicate that the GCB field has experienced exponential growth since 2014. Subjective norms, social influence, culture, marketing influence and social media influence are the main drivers of GCB. Eight research topics are identified, among which topics on the theory of planned behaviour (TPB) and the theory of consumption values (TCV) maintained high popularity. Furthermore, the TPB is more prevalent in the traditional context in which scholars prefer to predict GCB using macrosocial factors, such as policy and culture. In comparison, signal theory and commitment‐trust theory have received more attention in the digital context in which trust is vital. Research interests in online platforms and green hotels have recently increased in the digital context. Gaps and suggested directions for future studies are further identified.
Performance analysis of the compact haematology analyser Sight OLO
Authors: Leite Rui , Woodcock Sue , Brady Sally , Bigsby Charlotte , Webber Kay , Daniel Yvonne 
Published: September 2022

AbstractIntroductionSight OLO is a compact full blood count (FBC) analyser that uses digital imaging techniques and artificial intelligence to count and assess cellular components of capillary or venous blood. It provides a FBC with a 5‐part white blood cell differential count. Our aim was to evaluate its performance against our standard analyser and optical microscopy.MethodsComparative studies for the FBC parameters were done between the Sight OLO and the Unicel DxH800 analyser (Beckman Coulter). Evaluation comprised also repeatability studies and reproducibility studies. The flagging efficiency of the Sight OLO was assessed against the reference method (optical microscopy).ResultsThe SIGHT OLO showed a good comparability with the Unicel DxH800 analyser for most of the FBC parameters (r > 0.9). The biases recorded between both equipments were within the manufacturer's target specifications for all the FBC parameters. The standard deviation and coefficient of variation calculated per parameter for the precision studies were within the manufacturer's target specifications for all FBC parameters, for all the variation components tested. The five alert flags assessed showed an overall efficiency above 75%, however, high frequency of false negatives was noted for some of the flags assessed.ConclusionThe evaluation of the Sight OLO showed that it can produce accurate FBC results, making it a suitable option for integration in several setups. Its innovative methodology gives it further potential to refine its capabilities.
Evaluation of pore scattering in transparent ceramics: A simplified model for nanometric spherical pores
Authors: Zhao Xumei , Fang Qinglong , Xia Caijuan , Xie You , Wu Di , Chao Xiaolian , Yang Zupei 
Published: September 2022

AbstractIt is well known that light scattering by nanometric pores is adverse to realize a high transparency in ceramics; however, a suitable model that gives this phenomenon a quantitative evaluation is still lacking. In this work, a simplified model based on Rayleigh's theory was developed in order to unravel the light scattering by nanometric pores, taking polycrystalline KNNB‐xSm ceramics with high transparency (>67% at 780 nm) as example. The validity of this model was further verified by its good agreement with experimental results. Based on detailed simulations, we came to the conclusion that the pore volume fraction p is a more important parameter on the transparency of KNNB‐xSm ceramics than pore size dpore. Our findings in this work might provide inspiring insight to obtain highly transparent KNN‐based ceramics and more.