bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of probiotics use on clinical outcomes of immune checkpoint inhibitors therapy in cancer patients
Authors: Wan Luying , Wu Chunlan , Wu Qin , Luo Shuimei , Liu Junjin , Xie Xianhe 
Published: June 2022

AbstractBackgroundDysbiosis of the gut microbiota can lead to impaired therapeutic effect of immune checkpoint inhibitors (ICIs). This study aimed to investigate the use of probiotics on the clinical outcomes of cancer patients receiving ICIs therapy.MethodPubMed, EMBASE, and the Cochrane Library database were searched to retrieve relevant studies that exploring the relationship between probiotics and the efficacy of ICIs. The primary endpoints included overall survival (OS) and progression‐free survival (PFS), evaluated by the hazard rations (HRs) with 95% confidence intervals (CI), and the secondary endpoint was objective response rate (ORR), evaluated by the odd ratio (OR) with a 95% CI.ResultsA total of five studies including 1031 patients were eligible for analysis. Our results indicated that the use of probiotics was associated with a superior OS (HR = 0.50, 95% CI: 0.30–0.85, p = 0.01) and PFS (HR = 0.51, 95% CI: 0.42–0.61, p < 0.01), but had no relationship with ORR (OR = 2.11, 95%CI: 0.51–8.65, p = 0.30) in non‐small cell lung cancer (NSCLC) patients.ConclusionsProbiotics were positively correlated with OS and PFS in NSCLC patients administrated with ICIs, but had no relationship with ORR.
Supporting students’ career development: A call to action
Authors: Walker Becca , Bair Andrea R. , Macdonald R. Heather 
Published: June 2022

AbstractDrawing from examples of career development initiatives implemented by SAGE 2YC Faculty Change Agents, this chapter illustrates the role of career development in supporting the success of all community college students and guides faculty, administrators, and professional societies on how to advance student career development on a variety of scales. Career development as an integral component of community college science courses has major implications for increasing the diversity of science professionals, conveying the importance of science and scientific literacy in career sectors within and outside of the sciences, reducing equity gaps in students’ career development as undergraduates, and facilitating skill‐building necessary for the workforce. We urge community college science faculty and administrators to consider the powerful impact that career skill‐building and career exploration have on students and encourage the adoption of career development activities at the classroom, program, and institutional levels.
Simple Controllable Fabrication of Novel Flower‐Like Hierarchical Porous NiO: Formation Mechanism, Shape Evolution and Their Application into Asymmetric Supercapacitors
Authors: Wei Ying , Wu Yuwei , Cao Xiaoman , Cui Luxia , Chen Jiaqi , Wu Qiong , Liu Daliang , Sun Zhijia , Zhang Qingguo 
Published: June 2022

AbstractThe rational tailoring of micro‐ and mesoporous distribution for porous transition metal oxide‐based nanomaterials is an important factor to control their electrochemistry performances. Herein, flower‐like hierarchical microspheres assembled by ultrathin nickel oxide (NiO) nanosheets were synthesized by a facile solvothermal route and subsequent annealing process. Theoretical analysis and experimental results demonstrate that NiO ultrathin nanosheets prepared by calcination at 450 °C (N‐450) have the optimal micro‐ and mesoporous distribution. The optimal microstructure provides plenty of ion transport channels and abundant active sites. As expected, the N‐450 electrode delivers an ultrahigh specific capacity of 546.53 F g−1at a current density of 2 A g−1, which is greater than other electrodes. Remarkably, the assembled N‐450//AC asymmetric supercapacitor (ASC) achieves a high energy density of 29.7 Wh kg−1(at a power density of 800 W kg−1) and exhibits an excellent cycling stability. This work demonstrates an available avenue to enhance the performance of supercapacitor by accurately controlling calcination temperature to adjust the porous architectures of ultrathin NiO nanosheets.
Assessing salivary matrix metalloproteinase‐8 in prostate cancer patients undergoing androgen deprivation therapy
Authors: Memon Maaz A. , Aleem Benish , Memon Hifza A. , Lee Ka Y. 
Published: June 2022

AbstractIntroductionMatrix metalloproteinase‐8 (MMP‐8) is considered as one of the most promising diagnostic markers for periodontal disease. Androgen deprivation therapy (ADT) has been correlated with impaired collagen synthesis and an increase in periodontal tissue susceptibility to pathogenic microorganisms.ObjectiveThis study aims to investigate the impact of ADT on salivary MMP‐8 level and periodontal parameters, which might be useful in monitoring periodontal disease in prostate cancer patients undergoing ADT.Materials and MethodsA total of 88 subjects were selected and were divided into two groups: Group I included n = 78 PC patients who have been undergoing ADT); Group II included n = 10 healthy individuals. Periodontal parameters such as plaque index (PI), gingival index (GI), periodontal probing depth (PPD), and clinical attachment level (CAL) were examined. The salivary MMP‐8 level was estimated by using the sandwich enzyme‐linked immunosorbent assay method.ResultsSignificant differences in mean salivary MMP‐8 level were found between PC patients undergoing ADT and healthy individuals. Salivary MMP‐8 levels of all individuals were positively correlated with GI, PI, PPD, and CAL. Salivary MMP‐8 can distinguish between periodontitis and healthy individuals with an accuracy of about 80%.ConclusionSalivary MMP‐8 levels were found to be higher in prostate cancer patients undergoing ADT compared to healthy individuals.
Modified QuEChERS Method for Extracting Thiamethoxam and Imidacloprid from Stingless Bees: Development, Application, and Green Metrics
Authors: Rahman Asma , Ali Mian Abdul , Xavier Chubraider , Santos Dayana Moscardi , Daam Michiel Adriaan , Azevedo Eduardo Bessa , Brigante Castele Janete , Vieira Eny Maria 
Published: June 2022

Abstract
In the present study, a method for the determination of residues of the neonicotinoid insecticides thiamethoxam and imidacloprid in the stingless bee Melipona scutellaris Latreille (1811) was optimized through a factorial design, tested using green metrics, and then applied to exposed bees. It combines the extraction with a modified quick, easy, cheap, effective, rugged, and safe method and the determination by liquid chromatography–tandem mass spectrometry analysis. Different parameters such as the mass of the sample, dispersive sorbents, and elution solvents were assessed. Method validation parameters were checked and include sensitivity, specificity, and linearity. The limit of quantification of 0.0025 μg g–1 was obtained for both insecticides, where accuracy was 94%–100% with satisfactory intraday and interday precisions (relative standard deviation &lt;10%). The qualified method was applied to orally and topically exposed bee samples, and the results indicated that it is suitable for the determination and quantification of neonicotinoid pesticide residues in this species. Moreover, green analytical metrics like the National Environmental Methods Index, Eco Scale score, high-performance liquid chromatography with an environmental assessment tool (HPLC-EAT), waste generation, and amount of sample were compared with methods described in the literature involving neonicotinoid analysis in honeybees. As a result, the present study displayed the highest Eco Scale score and HPLC-EAT score and the second smallest amount of sample and waste generated. Thus, the method meets green analytical metrics more than other methods. In this sense, besides the application, the multicriteria decision analysis tool employed suggests that this is a good option as a green analytical method. Environ Toxicol Chem 2022;41:2365–2374. © 2022 SETAC
Abstract
Analysis of the neonicotinoids thiamethoxam and imidacloprid in the stingless bee Melipona scutellaris using modified QuEChERS for extraction and green metrics.
Evaluation of the likelihood of flashover in room fires involving a flat screen TV and the effect of flame retardant treatment of the casing
Authors: Janssens Marc L. , Schluneker Alexandra M. 
Published: June 2022

AbstractA study was performed to determine through computer fire modeling up to what extent a room fire in which a flat screen television is the first major item ignited is more likely to result in flashover if the television casing is not treated with flame retardants. This was accomplished by quantifying the risk of flashover in a living room or bedroom due to a fire in which a flat screen television is the first major item ignited, and by calculating the ratio of the risk measures for televisions with untreated casing versus those with flame retardant treated casing. This ratio is an indication of the increased likelihood of flashover should flame retardant treated television casings be replaced with untreated casings. The results of the risk quantification indicate that living room fires initiated with a flat screen television are between 4.2 and 15.2 times more likely to result in flashover when the casing is not treated with flame retardants compared to a flame retardant treated television. For fires in the (master) bedroom, the relative likelihood is between 4.1 and 15.5. The relative likelihood of flashover is slightly lower for apartments than for single family homes. The calculated ratio varies depending on the assumed probability that the ignition source is sufficiently severe to ignite a television with flame retardant treated casing.
Characterization of unusual iAMP21 B‐lymphoblastic leukemia (iAMP21‐ALL) from the Mayo Clinic and Children's Oncology Group
Authors: Koleilat Alaa , Smadbeck James B. , Zepeda‐Mendoza Cinthya J. , Williamson Cynthia M. , Pitel Beth A. , Golden Crystal L. , Xu Xinjie , Greipp Patricia T. , Ketterling Rhett P. , Hoppman Nicole L. , Peterson Jess F. , Harrison Christine J. , Akkari Yassmine M. N. , Tsuchiya Karen D. , Shago Mary , Baughn Linda B. 
Published: June 2022

AbstractAcute lymphoblastic leukemia (B‐ALL) with intrachromosomal amplification of chromosome 21 (iAMP21‐ALL) represents a recurrent high‐risk cytogenetic abnormality and accurate identification is critical for appropriate clinical management. Identification of iAMP21‐ALL has historically relied on fluorescence in situ hybridization (FISH) using a RUNX1 probe. Current classification requires ≥ five copies of RUNX1 per cell and ≥ three additional copies of RUNX1 on a single abnormal iAMP21‐chromosome. We sought to evaluate the performance of the RUNX1 probe in the identification of iAMP21‐ALL. This study was a retrospective evaluation of iAMP21‐ALL in the Mayo Clinic and Children's Oncology Group cohorts. Of 207 cases of iAMP21‐ALL, 188 (91%) were classified as “typical” iAMP21‐ALL, while 19 (9%) cases were classified as “unusual” iAMP21‐ALL. The “unusual” iAMP21 cases did not meet the current definition of iAMP21 by FISH but were confirmed to have iAMP21 by chromosomal microarray. Half of the “unusual” iAMP21‐ALL cases had less than five RUNX1 signals, while the remainder had ≥ five RUNX1 signals with some located apart from the abnormal iAMP21‐chromosome. Nine percent of iAMP21‐ALL cases fail to meet the FISH definition of iAMP21‐ALL demonstrating that laboratories are at risk of misidentification of iAMP21‐ALL when relying only on the RUNX1 FISH probe. Incorporation of chromosomal microarray testing circumvents these risks.
Flood disasters and health among the urban poor
Authors: Escobar Carías Michelle S. , Johnston David W. , Knott Rachel , Sweeney Rohan 
Published: June 2022

AbstractBillions of people live in urban poverty, with many forced to reside in disaster‐prone areas. Research suggests that such disasters harm child nutrition and increase adult morbidity. However, little is known about impacts on mental health, particularly of people living in slums. In this paper we estimate the effects of flood disasters on the mental and physical health of poor adults and children in urban Indonesia. Our data come from the Indonesia Family Life Survey and new surveys of informal settlement residents. We find that urban poor populations experience increases in acute morbidities and depressive symptoms following floods, that the negative mental health effects last longer, and that the urban wealthy show no health effects from flood exposure. Further analysis suggests that worse economic outcomes may be partly responsible. Overall, the results provide a more nuanced understanding of the morbidities experienced by populations most vulnerable to increased disaster occurrence.
Chemical profiling of composite prescription caraway and quantification of three pairs isomeric components in caraway administered rat plasma by tandem mass spectrometry
Authors: Wahefu Atikanmu , Abdulla Rahima , Lu Xueying , Liu Yongqiang , Aisa Haji Akber 
Published: June 2022

Caraway, a well‐known traditional Uyghur medicine, has been used to treat vitiligo for centuries. Its biological effects on melanin synthesis of caraway have been investigated. However, beyond psoralen and isopsoralen alone, no further chemical component of caraway has been revealed. In this study, ultra‐high performance liquid chromatography coupled with hybrid quadrupole orbitrap mass spectrometry was employed to comprehensively characterize the chemical components present in caraway. Based on accurate mass measurements, key fragmental ions and comparison with reference standards, 75 chemical components were identified in caraway. Moreover, a tandem mass spectrometry method was developed and validated for quantitative analysis of three pairs isomeric components, namely psoralen/isopsoralen, bavachin/isobavachalcone and bavachromene/isobavachromene in rat plasma. Psoralen, isopsoralen, bavachin, and isobavachalcone showed linearity with concentration ranging of 1.0–500.0 ng/ml. The linear ranges for bavachromene and isobavachromene were 0.2–500.0 ng/ml. The accuracies were in ranges of 85%–115% with coefficient of variation errors of less than 15%. Furthermore, the method was applied to quantify the three pairs isomeric components in rats after oral administration of caraway.
A modular surgical simulator for microlaryngoscopy using standard instruments and the carbon dioxide laser
Authors: Bressler Sara E. , Adkins Lacey K. , Dunham Michael E. , Walvekar Rohan R. , Jung Jangwook P. , Belgodere Jorge A. , Bao Adam X. , Breaux Lizabeth S. , Lee Hunter C. , Saneei Soheil , Veal Austin P. , Carleton John S. 
Published: June 2022

AbstractObjectiveBuild a microlaryngoscopy surgical simulator for endoscopic laryngeal surgery using standard microsurgical instruments and a CO2 laser.Study designAnatomical modeling, CAD design and 3D printed manufacturing.Subjects and methodsWe created a modular design for a microlaryngoscopy simulator in CAD software. Components include plastic and stainless‐steel models of a standard operating laryngoscope and a cassette system for mounting porcine or synthetic models of the vocal folds. All simulator parts, including the metallic laryngoscope model, were manufactured using 3D printing technology. Tumors were simulated in porcine tissue models by injecting a soy protein‐based tumor phantom. Residents and faculty in the Louisiana State University otolaryngology department evaluated the system. Each participant performed microlaryngoscopy with laser resection on a porcine larynx and cold instrument procedures on synthetic vocal folds. Participants scored the simulator using a 5‐point Likert scale.ResultsThe microlaryngeal surgical simulator demonstrated in this project is realistic, economical, and easily assembled. We have included 3D printed parts files and detailed assembly instructions that will enable educators interested in surgical simulation to build the device.Participants in the simulator evaluation session felt that the simulator faithfully represented the procedure to resect vocal fold lesions using a CO2 laser. The synthetic model allows the trainee to develop hand‐eye coordination while using standard laryngeal instruments.ConclusionsThe simulator described herein will enable surgeons to acquire the surgical skills necessary to perform operative microlaryngoscopy prior to operating on live patients.
Preparation, Crystallization Behavior, Simultaneous Spectroscopic and Rheological Characterization of Polyphenylene Sulfide/Graphene Quantum Dots Nanocomposites
Authors: Wang Chunyao , Li Chen , Zhen Weijun , Zhao Ling , Wang Shigang , Huang Shengbing 
Published: June 2022

AbstractGraphene quantum dots are prepared conveniently and quickly with brown‐black humic acid as raw material by green oxidation process. The average size of GQDs is about 12 nm with a lattice spacing of 0.26 nm and GQDs have hydroxyl and carboxyl functional groups on their surface. Moreover, photoluminescence testing shows that GQDs have excellent photoluminescence properties with maximum excitation/emission wavelength at 347/478 nm. Next, polyphenylene sulfide (PPS)/GQDs nanocomposites are prepared by melt blending with GQDs and PPS. Mechanical tests show that the tensile strength and the impact strength of PPS can be greatly improved when the amount of GQDs is 0.5 wt% and tensile strength and the impact strength are increased by 53.38% and 375%, respectively. The nonisothermal crystallization of PPS/GQDs nanocomposites is investigated by differential scanning calorimetry, which shows that GQDs effectively increase the crystallization rate of PPS. The crystallization of PPS/GQDs nanocomposites during cooling are studied by Rheonaut technology analysis. The rheological results show that the storage modulus of PPS/GQDs (0.5 wt%) nanocomposites is increased by about 1.04 times than that of pure PPS, and 2D IR spectrum confirms that GQDs accelerate crystallization of PPS. Rheological studies present that GQDs have good compatibility with PPS.
Ferienlabor: Brennende Gummibärchen und danach Freibad
Authors: Schygulla Jennifer , Sitzmann Helmut 
Published: June 2022

AbstractNach einer pandemiebedingten Pause experimentieren in diesem Jahr am Fachbereich Chemie der TU Kaiserslautern wieder Mittel‐ und Oberstufenschüler:innen. Diese Art der Ferienfreizeit begann vor mehr als 15 Jahren mit Mikroskopen für das anorganisch‐chemische Grundpraktikum.
Blickpunkt Nachwuchs: Theoretische Elektrokatalyse
Authors: Exner Kai S. 
Published: June 2022

AbstractTheoretische Untersuchungen an Elektrodenmaterialien für elektrochemische Prozesse tragen zu einer nachhaltigen Energiewirtschaft bei, indem leistungsfähige Katalysatorkompositionen mit heuristischen Konzepten vorhergesagt werden. Aduc‐Preisträger Kai S. Exner entwickelt Modelle, die Kandidatenmaterialien identifizieren und Sackgassen vermeiden sollen.
Bilanzen: Nachfrage, Lieferketten, Preise
Authors: Zbikowski Frauke 
Published: June 2022

AbstractIm vergangenen Jahr erhöhte die Coronapandemie den Bedarf an Verbrauchsmaterialien für Labore und bestimmte die Geschäfte der Hersteller von Analysegeräten und ‐zubehör. Für das laufende Jahr wagen nur wenige Laborzulieferer Prognosen.
24. Steinheimer Gespräche: RNA‐Vakzine und ‐Medikamente
Authors: Krause Simon 
Published: June 2022

AbstractAnfang Mai fanden die 24. Steinheimer Gespräche für den Hochschullehrernachwuchs in Mainz statt. An der dreitägigen Veranstaltung, ausgerichtet vom Fonds der Chemischen Industrie (FCI), nahmen Liebig‐Stipendiaten, etablierte Hochschulwissenschaftler:innen sowie Vertreter:innen der Industrie teil. In diesem Jahr fand nach einjähriger Pause im Jahr 2020 und einer digitalen Version 2021 die Konferenz wieder in persona statt. Thomas Carell (LMU München und stellvertretender Kuratoriumsvorsitzender des Fonds) führte durch die Veranstaltung mit dem Rahmenthema „Aufbruch in die Chemie der RNA‐Vakzine und ‐Medikamente“.
Mit Partikelanalysedie Produktion pharmazeutischer Emulsionen optimieren
Authors: Fronk Vanessa , Schäffler Michael , Bonyadi Hossa , Herbig Michael , Köllmer Melanie 
Published: June 2022

AbstractDie Partikelgrößenverteilung ist ein Qualitätsmerkmal pharmazeutischer Öl‐in‐Wasser‐Emulsionen. Kombiniert mit den Ergebnissen rheologischer Untersuchungen hilft sie dabei, die Herstellprozesse zu verbessern.
Symposium „Forschung der chemischen Industrie“ in Münster
Authors: Das Mowpriya , Pierau Marco 
Published: June 2022

AbstractIndustrielle Forschung trifft auf Akademia – unter diesem Motto steht das Symposium „Forschung der chemischen Industrie“ (FoChIn) der Universität Münster. Nach zwei Jahren Pandemie öffnete der Fachbereich Chemie und Pharmazie am 12. Mai zum zehnten Mal seine Tore für Studierende, Wissenschaftler:innen und Wissenschaftsinteressierte. Ziel ist der Austausch zwischen Universität und der chemischen Industrie. Auf dem Programm standen Vorträge zu moderner organischer Molekülchemie von Wissenschaftlern aus fünf Unternehmen; organisiert hat die Veranstaltung Frank Glorius.
Coastal transformations and connections: Revealing values through the community voice method
Authors: Acott Timothy G. , Willis Cheryl , Ranger Sue , Cumming Gabriel , Richardson Peter , O'Neill Rose , Ford Adriana 
Published: June 2022

Abstract

A wealth of evidence suggests an important relationship between nature and human health and well‐being and this appears to hold particular resonance for coastal environments. Notably, this relationship has been explored in assessments of ecosystem services, or the benefits that people derive from nature.

In this paper, we extend the debate to encompass ideas around relational values which considers that human well‐being is derived from relationships with nature rather than being solely delivered as the benefits commonly suggested in the ecosystem services literature.

The paper draws on conceptual ideas around relational values, sense of place and environmental justice to understand the values and importance of coastal environments for people.

These value concepts are explored through detailed narratives revealed by participants in two case study UK coastal locations, using a form of civic dialogue and videography approach called Community Voice Method (CVM).

We find that despite levels of relative deprivation in our case study locations, interviewees express values which are striking in terms of the depth of care felt; values which are ‘time‐deepened’ and shaped not only by what people do and are able to do, but also by personal histories and memories which remain strong despite material changes and transformations in people's lives and the places they live.

The CVM method in addition provides a practical approach for creating deliberative spaces to explore those deeply embodied and shared connections to the coast which are important and should have greater prominence in coastal management policy and practice.