bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental evaluation of polymer construction materials: effects of acrylic resin and a fiberglass-based composite upon cytokine production
Authors: Godovalov A. P. , Astashina A. B. , Bazhin A. A. , Drokina T. A. 
Published: July 2022

Polymethyl methacrylate-based acrylic resin is commonly used in current dental practice as an underlying material for fabrication of overdenture restorations. To increase service life of laminar overdentures, we have developed a technique to fabricate a novel combined base for a full overdenture using a fiberglass-based composite. It makes sense to evaluate probable hazards of inflammatory process which could be activated when using structural polymer materials and composites in dental practice. Our study aimed for assessment of changes in production of key cytokines (interferon-y and interleukin-4) by ex vivo incubated human mononuclear leukocytes in the presence of acrylic resin and fiberglass-based composite.The experiments dealt with peripheral venous blood leukocytes obtained from 13 apparently healthy male volunteers (mean age = 24 years). The leukocytes were isolated from heparinized blood by gradient centrifugation. The cells were cultured in plastic round-bottom 96-well plates, in moist atmosphere with 5% CO2 at 37 °C for 72 h. Following the incubation, the culture supernates were collected and frozen for further determination of cytokine concentration using ELISA reagent kits for interferon-y and interleukin-4 measurement (Vector-Best, Russia). The samples of two structural materials were tested in the bioassays: the specimens of acrylic resin, Ftorax were compression-moulded by hot polymerization in prefabricated casts; the specimens of a composite, Trinia, were computer-milled. Glass specimens of similar shape and size were used as references. The statistical analysis used a software package, Statistica 7.0. Significance of the differences was evaluated using the Student's test and the Mann-Whitney test. When testing the statistical hypotheses, the significance level (p) was taken to be 0.05.Significant decrease of IFNγ production was revealed in presence of Trinia than in the samples with glass and with the acrylic specimens, whereas cell viability counts did not differ from the blank values. There was no statistical differences in IL-4 production between the samples with the polymer materials and the glass. When estimating individual stimulation indexes, the materials used in this research were found to showed a pronounced stimulatory effect with peripheral blood lymphocytes from only one volunteer. These findings indicate that Trinia triggers anti-inflammatory activity of leukocytes, whereas IFNγ production level is somewhat decreased, and IL-4 production remains unchanged.Thus, the research assessed the method for personalized evaluation of reactivity of prosthodontic structural polymer materials. Absence of increase in lymphocytic production of key cytokines can be regarded as a hopeful sign which indicates that inflammatory process is not activated when Trinia is used in overdenture bases.
Identification of Surface Glycoprotein Mutations of SARS-CoV-2 in Isolated Strains from Iraq
Authors: Dawood Ali A. , Jasim B. I. , Riadh Al-Jalily O. 
Published: July 2022

Background: The global pandemic of coronavirus disease is a societal, economic, and publichealth crisis that is still underway. The spike glycoprotein of SARS-CoV-2 is one of the primary ingredients for virulence, tissue tropism, and host areas. Aim: This study aimed to determine mutations in the S protein of the Iraqi COVID-19 isolates.Full genome sequences of Iraqi strains were obtained from GISAID. Using statistical saturation mutagenesis and other informatics methods, we investigated 20 sequences of SARS-CoV-2 S protein missense mutation isolates in Iraq selected from NCBI.The following mutations were detected for all the strains under study compared to the wild type: L452R, A522V, E583D and D614G. The number of mutations in the strains was different depending on the location of the state from which the sample was collected The D614G mutation was found in 19 strains. One strain had three mutations, while the other was a wild form strain. The structure of the mutant protein changes dramatically, as does the energy of the atoms concerning the docking position, affecting the protein's stability.The mutation sites would improve the S protein's stability. Molecular docking of RBD-ACE2 is affected differently by residues L452R and A522V.
Role of allergy in the development of alopecia areata
Authors: Barilo A. A. , Smirnova S. V. 
Published: July 2022

Alopecia areata is an autoimmune disease characterized by non-scarring hair loss with preservation of the hair follicle. Hair loss in alopecia areata can be either focal with the appearance of clearly defined foci of alopecia, or diffuse or complete hair loss in any area of the skin where hair follicles are present. Data on the role of food allergy in the development of alopecia areata and the nature of the sensitization spectrum are extremely scarce. Objective: to study the features of the spectrum of sensitization to food and pollen (cross-reacting) allergens in patients with alopecia areata.The study involved patients with alopecia areata (n = 17), who were divided into groups according to age: group 1 — children (n = 9) and group 2 — adults (n = 8). All patients underwent a specific allergological examination: collection of an allergic history, skin prick testing with food and pollen allergens (Allergopharma, Germany).Analysis of the spectrum of sensitization to food allergens in patients with alopecia areata revealed features depending on their age. Thus, in the group of sick children, the highest frequency of sensitization to whole chicken eggs, food cereals, yeast, soybeans and cow's milk proteins was noted. In the group of sick adults, the most significant food allergens were: egg protein, rye flour, oats. Among the pollen allergens in the first group of patients, the most common allergens were a mixture of weed and grass pollen, in the second group, a mixture of meadow grass pollen. All patients, taking into account allergological testing, were administered an individual elimination diet with the exclusion of causally significant allergens, taking into account crossreacting allergens. The elimination effect was assessed 2 months after the start of the elimination diet. 70% of patients showed a clinical improvement, i.e., the growth of vellus was noted (vellus depigmented hair) in the foci of alopecia, as well as terminal pigmented hair. Complete regression of alopecia foci occurred on average within 3-6 months from the start of therapy.The sensitization to food and pollen (cross-reacting) allergens in patients with alopecia areata and the positive effect of the elimination diet revealed in our study well supports the role of food allergy in the development of this disorder. Therefore, the study of the causal relationship between food allergy and alopecia areata is of particular relevance and creates prerequisites for the discovery of new diagnostic and therapeutic options.
The ventral precuneal‐posterior cingulate region as a site of epileptogenicity
Authors: Elisevich Lee , Abbas Shan , Burdette David , Heredia Gabe , Elisevich Kost 
Published: July 2022

AbstractThe ventral precuneal and posterior cingulate area (VP‐PC) represents a distinct but topographically variable mesial parietal site of epileptogenicity that may manifest as a common temporal lobe‐mediated ictal expression. In a review of records of 62 presumptive epilepsy surgery cases, two cases of primary epileptogenicity expressed within the VP‐PC were identified and are detailed to bring attention to this electroencephalographically‐hidden area of ictal expression. Details of their investigation and surgical treatment illustrate distinctly different approaches addressing the problem and bringing about a seizure‐free outcome.
Heredabilidad de los componentes de las medidas cefalométricas ODI, APDI y del Triángulo de McNamara en pacientes con maloclusión esquelética clase II y clase III, que asisten a la clínica odontológica de la Universidad Cooperativa de Colombia
Authors: Enriquez Jamauca Lizeth Alexandra , Cordoba-Pantoja Ángela , Argotte-Arciniegas Érika , Calderón-Moncayo Luís Fernando , López-Ordoñez Alexander , Fong Cristian 
Published: July 2022

La maloclusión es una entidad patológica asociada con anomalías en crecimiento y desarrollo craneofacial en donde intervienen factores genéticos y ambientales. El papel de la heredabilidad ha sido ampliamente investigado en estudios craneométricos y cefalométricos de similitudes faciales, donde se ha evidenciado que la forma facial, es resultado del genotipo del individuo, por consiguiente, la apariencia facial presenta una tendencia hereditaria familiar. Objetivo: Determinar la heredabilidad de los componentes de las medidas cefalométricas compuestas: ODI y APDI y del Triángulo de McNamara en pacientes con maloclusión esquelética clase II y clase III, que asisten a la clínica de Ortodoncia de la UCC- Campus Pasto.Metodología: Enfoque cuantitativo, Observacional, descriptivo de corte transversal, que utiliza una muestra total de 60 pares de hermanos. El porcentaje de heredabilidad fue calculado mediante la prueba de regresión lineal Haseman Elston, donde un valor mayor a 80% se considera altamente heredable y valores de P<0.05 se consideraron significativos. Resultados: Los componentes que presentaron mayor heredabilidad fueron; la medida cefalométrica compartida entre los componentes de ODI y APDI, el ángulo Plano de Frankfort-Plano Palatino, con el 100% y la medida lineal Condilion-Gnation con un 98%. Conclusiones: El tamaño mandibular está influenciado por factores altamente heredables, pero la posición mandibular, representada por Plano facial - Plano de Frankfort y ENA-Me presentan una baja heredabilidad, es decir altamente adaptables. Las medidas cefalométricas como Plano facial-Plano AB y Plano Mandibular -Plano AB, son el resultado de una relación entre el maxilar y la mandíbula, presentando una baja heredabilidad, lo que sugiere que están influenciadas por factores externos inherentes a cada sujeto.
Amelogénesis imperfecta
Authors: Simancas Escorcia Victor Hugo , Luján María del Pilar 
Published: July 2022

Introducción: La Amelogénesis Imperfecta (AI) constituye un grupo heterogéneo de alteraciones que impactan la estructura del esmalte dental de origen genético. Esta patología producto de cambios fisiológicos durante la odontogénesis, modifica la estructura y apariencia clínica del esmalte, otorgándole un aspecto delgado y de menor resistencia. Se ha descrito que la AI puede aparecer de manera aislada o de manera sindrómica.
Propósito: Describir los síndromes que impactan el sistema renal y cursan con amelogénesis imperfecta de acuerdo a la evidencia científica actual.
Método: se realizó una búsqueda electrónica de literatura hasta septiembre de 2019, con los términos Amelogenesis imperfecta, renal AND/OR Amelogenesis Imperfecta y Syndrome AND/OR Amelogenesis Imperfecta.
Resultados: Fueron pre-seleccionando 1660 artículos, de los cuales 52 fueron tenidos en cuenta para esta revisión. Se identificó que el síndrome Amelogénesis imperfecta-Nefrocalcinosis, Síndrome de Raine, Síndrome de Bartter, Acidosis tubular renal distal y la Hipomagnesemia primaria familiar con hipercalciuria y nefrocalcinosis son afecciones renales que cursan concomitantemente con un fenotipo dental.
Conclusión: Esta revisión ha permitido demostrar que las alteraciones del esmalte dental tipo AI constituye un signo de alerta para entidades patológicas que impactan el funcionamiento renal. Se recomienda que los profesionales de la odontología, una establecido el diagnosticado de amelogénesis imperfecta, consideren realizar la remisión de estos pacientes a un servicio de nefrología.
Síndrome de Burnout por COVID-19 en personal sanitario en áreas UCI y Emergencia de un hospital de segundo nivel
Authors: Cedeño-Guevara Pamela , Escobar Segovia Kenny Fernando 
Published: July 2022

Introducción: En la actualidad la enfermedad del Coronavirus 2019 (COVID-19) trajo un abrumador impacto en los sistemas y el personal hospitalario, por lo que, en atención al bienestar de los profesionales de la salud en todo el mundo se ha vuelto imperativo apoyar y monitorear adecuadamente los casos encontrados, ya que la situación del COVID-19 generó en la mayoría de los profesionales de la salud un fuerte impacto psicológico como resultado del estrés y la frustración del día a día y de las extenuantes jornadas laborales. Objetivo: El presente trabajo de investigación tiene como objetivo conocer la prevalencia de Síndrome de Burnout en el personal sanitario que labora en un hospital de segundo nivel de Loja – Ecuador, durante la pandemia por Covid19, mediante la aplicación de la escala Maslach Burnout Inventory. Para el cumplimiento de éste, Métodos: se empleó el método de investigación de tipo descriptivo, cuantitativo; el instrumento fue aplicado a 55 profesionales sanitarios que laboran en las áreas de emergencia y UCI. Resultados: Como resultado de la investigación se determinó que el 9,1% del personal encuestado padece de Burnout grave, la dimensión del SB con mayor incidencia fue el cansancio emocional, seguido de la despersonalización, finalmente se estableció que las mujeres son las más afectadas por esta enfermedad
Predictors of reported alcohol intake during the first and second waves of the COVID-19 pandemic in Canada among middle-aged and older adults: results from the Canadian Longitudinal Study on Aging (CLSA)
Authors: McMillan Jacqueline M. , Hogan David B. , Zimmer Chantelle , Sohel Nazmul , Wolfson Christina , Kirkland Susan , Griffith Lauren E. , Basta Nicole E. , Raina Parminder ,   on behalf of the Canadian Longitudinal Study on Aging (CLSA) Team
Published: July 2022

Abstract
Objective
To examine proportions and predictors of change in alcohol intake and binge drinking during the first 2 waves of the COVID-19 pandemic among middle-aged and older participants in the Canadian Longitudinal Study on Aging (CLSA) COVID-19 Questionnaire Study.

Methods
A total of 28,559 (67.2% of the potential sample) CLSA participants consented to the study with 24,114 completing the exit survey (fall 2020). Descriptive statistics and logistic regressions to examine predictors of change (increase or decrease) in alcohol intake and binge drinking were performed.

Results
Among alcohol users, 26.3% reported a change in alcohol consumption during the first 10 months of the pandemic. Similar percentages increased (13.0%) or decreased (13.3%) consumption. In our mutually adjusted logistic regression model, odds of change in alcohol intake were greater for younger age, higher income, current cannabis smoker, positive screen for depression, anxiety, and loneliness. The magnitude of all associations for decreased intake was less than that of increased intake, and the directions were opposite for male sex and age. Predictors of current binge drinking (27.9% of alcohol users) included male sex, younger age, higher education and income, cannabis use, depression, and anxiety.

Conclusion
Factors predictive of potentially worrisome alcohol use (i.e. increased intake, binge drinking) included younger age, sex, greater education and income, living alone, cannabis use, and worse mental health. Some of these factors were also associated with decreased intake, but the magnitudes of associations were smaller. This information may help direct screening efforts and interventions towards individuals at risk for problematic alcohol intake during the pandemic.
Pelatihan Seni Budaya dan Prakarya untuk Meningkatkan Kualitas Pembelajaran Senirupa bagi Guru SD di Kecamatan Ponorogo Kabupaten Ponorogo
Authors: Sumanto Sumanto , Sukamti Sukamti 
Published: July 2022

training of cultural arts and crafts for elementary school teachers aims to train skills: (1) make a woven paper asturo, (2) a technique to print high-ingredient sterefoam, cardboard and packaging waste stationery (to improve the quality of teaching art in elementary school. Methods training by providing individual practical guidance on weaving and high-scoring skills directly to 26 elementary school teachers.Results (1) non-physical for elementary school teachers in Ponorogo sub-district who are very interested in art-craft training, and are willing to disseminate knowledge and skills to teachers (2) individual training participants are skilled at making (a) woven planes, fish, flying birds, stars, boxes, and framed ribbons, (2) High Print works on HVS paper from Sterefoam's references, Cardboard and stationery packaging waste materials.pelatihan seni budaya dan prakarya bagi guru SD ini bertujuan melatih keterampilan: (1) membuat anyaman dari kertas asturo, (2) teknik mencetak tinggi bahan sterefoam, kardus, dan limbah kemasan alat tulis (untuk meningkatkan kualitas pembelajaran senirupa di SD. Metode pelatihan dengan memberikan bimbingan praktek individu keterampilan menganyam dan mencetak tinggi secara langsung kepada 26 guru SD. Hasil (1) non-fisik bagi guru-guru SD di kecamatan Ponorogo sangat berminat mendapat pelatihan senirupa-prakarya, dan bersedia untuk menyebarluaskan pengetahuan dan keterampilan kepada guru lain di tempat tugasnya. (2) peserta pelatihan secara individu terampil membuat (a) anyaman bentuk pesawat, ikan, burung terbang, bintang, kotak, dan anyaman pita bentuk pigura, (2) karya Cetak Tinggi di atas kertas HVS dari acuan Sterefoam, Kardus, dan bahan limbah kemasan alat tulis.
Peningkatan Kualitas Pendidik PAUD Pandan Wangi Melalui Pelatihan dan Penataan Administrasi
Authors: Astuti Febru Puji , Hestinarini Tuti , Surohmah Yuli , Adrikni Khilati , Putri Melati Retnandhia , Cahyani Ratih Putri 
Published: July 2022

One of the problems in PAUD Pandan Wangi institutions is the economic field which refers to problems regarding the financial condition of institutions and local wisdom materials that have not been utilized to the maximum. The education sector refers to the problem of the lack of early childhood education educator qualifications and competencies caused by educational backgrounds that are not under early childhood education educator standards. This service program aims to improve the competence of early childhood education educators by conducting teacher training that focuses on early childhood education management programs, learning methods, and classroom management as well as training in making products based on local wisdom that is of value. The evaluation results show that the material is per the needs and expectations of the trainees. Permasalahan di lembaga PAUD Pandan Wangi salah satunya adalah bidang ekonomi yang mengacu pada permasalahan tentang kondisi keuangan lembaga dan material kearifan lokal yang belum dimanfaatkan dengan maksimal. Bidang pendidikan mengacu pada permasalahan kurangnya kualifikasi dan kompetensi pendidik PAUD disebabkan oleh latar belakang pendidikan yang belum sesuai dengan standar pendidik PAUD. Program pengabdian ini bertujuan untuk meningkatkan kompetensi pendidik PAUD dengan melakukan pelatihan guru yang berfokus pada program pengelolaan PAUD, metode pembelajaran, dan pengelolaan kelas serta pelatihan pembuatan produk berbasis kearifan lokal yang bernilai jual. Hasil evaluasi menunjukkan bahwa materi sesuai dengan kebutuhan dan harpan peserta pelatihan.
Pelatihan Sistem Informasi Pembelajaran Anak Usia Dini bagi Lembaga PAUD
Authors: Gonadi Leni , Wulandari Retno Tri , Desyanty Ellyn Sugeng 
Published: July 2022

This community service aims to (1) increase educators' knowledge about early childhood learning information systems and (2) increase the ability of PAUD educators in applying information systems to the learning process. Training activities are carried out through the delivery of material, discussions, and exercises in the use of information systems in the learning process. The training was carried out in two stages namely; introduction of early childhood learning information systems and direct use practices. This activity has a positive impact on PAUD educators Lowokwaru District as shown by the results of the training of 75 percent of educators having knowledge of early childhood learning information systems and 85.4 percent of educators being able to operate early childhood learning information systems. Pengabdian masyarakat ini bertujuan untuk (1) meningkatkan pengetahuan pendidik tentang sistem informasi pembelajaran anak usia dini dan (2) meningkatkan kemampuan pendidik PAUD dalam mengaplikasikan sistem informasi pada proses pembelajaran. Kegiatan pelatihan dilaksanakan melalui penyampaian materi, diskusi, dan latihan penggunaan sistem informasi pada proses pembelajaran. Pelatihan dilaksanakan dalam dua tahap yaitu; pengenalan sistem informasi pembelajaran anak usia dini dan praktek langsung penggunaan. Kegiatan ini memberi dampak positif bagi pendidik PAUD hal ini ditunjukkan dengan hasil pelatihan sebanyak 75 persen dari 30 pendidik PAUD se Kecamatan Lowokwaru memiliki pengetahuan tentang sistem informasi pembelajaran anak usia dini dan 83,3 persen pendidik dapat mengoperasikan sistem informasi pembelajaran anak usia dini melalui pendampingan.