bluuebunny/crossref_metadata_2025_split huggingface dataset:
MDCD: A malware detection approach in cloud using deep learning
Authors: Tian Donghai , Zhao Runze , Ma Rui , Jia Xiaoqi , Shen Qi , Hu Changzhen , Liu Wenmao 
Published: June 2022

AbstractWith the increasing popularity of cloud computing applications, the threat of malware attack against cloud environments is getting worse. To defend against malware attacks in the cloud, some virtualization‐based approaches are proposed. However, the existing methods suffer from limitations in terms of detection accuracy, deployment effort, and performance cost. To address these issues, we propose MDCD, a novel dynamic malware detection solution for cloud environments. This method first utilizes a lightweight agent to collect the run‐time utilization information from the target virtual machine (VM). Then, it leverages the memory forensics analysis technique to extract the memory object information from the target VM's memory. To fully make use of the run‐time utilization and memory object information for malware detection, we propose a multi‐CNN model, which combines multiple convolutional neural networks (CNNs) efficiently. The evaluation shows that our approach can achieve an average detection accuracy, precision, recall, and F1 Score of 98.89%, 97.01%, 98.17%, and 97.89% respectively. Compared with the existing solutions, our method can detect multiple malicious processes effectively with little deployment effort.
Brits and British Muslims and their perceptions of cultured meat: How big is their willingness to purchase?
Authors: Boereboom Anouk , Sheikh Mustapha , Islam Tajul , Achirimbi Elma , Vriesekoop Frank 
Published: June 2022

AbstractConsumer preferences regarding food in general, livestock meat and cultured meat among Muslim populations remains largely unknown, especially in a United Kingdom context. This is a significant gap in our understanding since foods that meet halal requirements have a major economical share of both the British and the global food market. The aim of this study is threefold: (1) gain insight into the perceptions of the broader British community and the Muslim demographic within it regarding food choice determinants, livestock meat, and cultured meat; (2) investigating similarities and differences within and between the two groups; and (3) model the willingness to purchase (WTPu) cultured meat for both populations. The British Muslim and the British non‐Muslim population are very similar in their considerations about food in general, livestock meat and cultured meat. With regard to the willingness to purchase cultured meat, further product development and marketing strategies should focus on the same factor for both populations: the healthiness, safety, and nutritional characteristics of cultured meat.
Development of informant‐reported or self‐reported MCI‐J questionnaire
Authors: Asada Takashi , Kakuma Tatsuyuki , Ota Miho , Jon Lebowitz Adam , Shibata Nobuto , Niizato Kazuhiro , Izumimoto Norihiko , Abe Yasuko , Tanaka Mieko , Arai Tetsuaki 
Published: June 2022

AbstractSeveral studies have reported a high prevalence of missed and delayed mild cognitive impairment (MCI) or mild dementia diagnosis, which could lead to delayed treatment and increased patient and caregiver burden.ObjectivesThis study aimed to develop a new questionnaire for nonprofessionals to help detect early signs of MCI and dementia. Respondents included patients, family caregivers, or health professionals. Scores are calculated based on the respondent type and age of subject.MethodsThis study consisted of four steps and included 461 respondents. Steps 1–3 were conducted by a working group, and step 4, by 67 specialist members of the Japanese Society of Geriatric Psychiatry. A scoring algorithm was created and predictive diagnostic probability was analyzed using misdiscrimination rate and cross‐validation after item selection to establish a cut‐off value for MCI or dementia symptoms. Alzheimer's disease, Lewy body dementia, and frontotemporal dementia were diagnosed.ResultsThe prediction error rate for patient or informant respondents was confirmed from the evaluation results of 13 items. Sensitivity and specificity were 90.6% and 56.6%, respectively, with a cut‐off score of 2. Overall, 82% (61 pairs) of respondents received a definitive diagnosis following a diagnosis from the questionnaire.ConclusionsThis questionnaire could promote earlier presentation to clinical settings for treatment. The high sensitivity indicates the utility of this instrument, but it is not meant as a definitive diagnostic tool and should be followed with a professional assessment.
The role of the ventrolateral anterior temporal lobes in social cognition
Authors: Balgova Eva , Diveica Veronica , Walbrin Jon , Binney Richard J. 
Published: June 2022

AbstractA key challenge for neurobiological models of social cognition is to elucidate whether brain regions are specialised for that domain. In recent years, discussion surrounding the role of anterior temporal regions epitomises such debates; some argue the anterior temporal lobe (ATL) is part of a domain‐specific network for social processing, while others claim it comprises a domain‐general hub for semantic representation. In the present study, we used ATL‐optimised fMRI to map the contribution of different ATL structures to a variety of paradigms frequently used to probe a crucial social ability, namely ‘theory of mind’ (ToM). Using multiple tasks enables a clearer attribution of activation to ToM as opposed to idiosyncratic features of stimuli. Further, we directly explored whether these same structures are also activated by a non‐social task probing semantic representations. We revealed that common to all of the tasks was activation of a key ventrolateral ATL region that is often invisible to standard fMRI. This constitutes novel evidence in support of the view that the ventrolateral ATL contributes to social cognition via a domain‐general role in semantic processing and against claims of a specialised social function.
Human papillomavirus self‐sampling with mRNA testing benefits routine screening
Authors: Auvinen Eeva , Nieminen Pekka , Pellinen Jukka , Dillner Joakim , Tarkkanen Jussi , Virtanen Anni 
Published: June 2022

AbstractHigh risk human papillomavirus (hrHPV) based screening provides the possibility of vaginal self‐sampling as a tool to increase screening attendance. In order to evaluate the impact and feasibility of opt‐in self‐sampling in the Finnish setting, we invited a randomized population of 5350 women not attending screening after age group invitation or after reminder, to attend HPV self‐sampling‐based screening in the autumn of 2018 in Helsinki. Out of those, 1282 (24.0%) expressed their interest and ordered the sampling package. Eventually 787 women (14.7% of the total invited population) took part in screening, 770 women by providing a vaginal sample within 2 months from invitation and 17 by providing a pap smear in the laboratory. Self‐taken samples were collected in Aptima Multitest vials and tested using the Aptima HPV mRNA assay. A high proportion, 158/770 (20.5%) of the samples were positive in the Aptima HPV assay. One hundred and forty‐one samples were further submitted to Aptima HPV Genotyping and extended genotyping by a Luminex based assay. Of those, 23 samples (16.3%) were HPV 16 positive and 7 (5.0%) were positive for HPV 18/45; extended genotyping revealed multiple high‐risk and low‐risk HPV genotypes. At follow‐up seven cases of high‐grade squamous intraepithelial lesion (HSIL) were diagnosed, which represents 4.4% of HPV positive women and 0.9% of screened women, whereas the rate was 0.5% in routine screening. Our findings suggest that self‐sampling with HPV mRNA testing is a feasible approach to improve screening efficacy in a high‐risk population among original nonattendees.
Single‐cell RNA‐seq dissecting heterogeneity of tumor cells and comprehensive dynamics in tumor microenvironment during lymph nodes metastasis in gastric cancer
Authors: Qian Yan , Zhai Ertao , Chen Sile , Liu Yinan , Ma Yan , Chen Junting , Liu Jianqiu , Qin Changjiang , Cao Qin , Chen Jianhui , Cai Shirong 
Published: June 2022

AbstractLymph node metastasis is the common metastasis route of gastric cancer. However, until now, heterogeneities of tumor cells and tumor microenvironment in primary tumors (PT) and metastatic lymph nodes (MLN) of gastric cancer (GC) remains uncharacterized. In our study, single cell RNA sequencing was performed on tissues from PT and MLN of gastric cancer. Trajectory analysis and function enrichment analyses were conducted to decode the underlying mechanisms contributing to LN metastasis of gastric cancer. Heterogeneous composition of immune cells and distinct intercellular interactions in PT and MLN were analyzed. Based on the generated single cell transcriptome profiles, dynamics of gene expressions in cancer cells between PT and MLN were characterized. Moreover, we reconstructed the developmental trajectory of GC cells' metastasis to LN and identified two subtypes of GC cells with distinct potentials of having malignant biological behaviors. We characterized the repression of neutrophil polarization associated genes, like LCN2, which would contribute to LN metastasis, and histochemistry experiments validated our findings. Additionally, heterogeneity in neutrophils, rather than macrophages, was characterized. Immune checkpoint associated interaction of SPP1 was found active in MLN. In conclusion, we decode the dynamics of tumor cells during LN metastasis in GC and to identify a subtype of GC cells with potentials of LN metastasis. Our data indicated that the disordering the neutrophils polarization and maturation and the activation of immune checkpoint SPP1 might contribute to LN metastasis in GC, providing a novel insight on the mechanism and potential therapeutic targets of LN metastasis in GC.
Using ROM in family therapy
Authors: Tilden Terje , Whittaker Kristoffer J. 
Published: June 2022

AbstractBackgroundRoutine outcome monitoring (ROM) is in this article defined as a tool for feedback‐informed therapy where clients' therapy relevant information is applied in real‐time therapy. Because family therapy represents a comprehensive clinical setting, ROM is experienced as particularly useful.AimsIn a vignette from family therapy practice, the use of ROM is demonstrated on individual, couple, and family levels with reference to integrative systemic therapy.DiscussionROM information is shown to play a central role in the different phases of treatment. It is demonstrated how ROM facilitates patient‐centered assessment that strengthens the therapeutic collaboration such as the working alliance, identifying treatment targets, and possible constraints. In particular, ROM revealing alliance rupture followed by alliance repair is emphasized as a crucial therapeutic event in this treatment.
“Even Though We Have Different Colors, We Are All Equal Here”: Immigrants building a sense of community and wellbeing through sport participation
Authors: Corvino Chiara , Martinez‐Damia Sara , Belluzzi Mattia , Marzana Daniela , D'Angelo Chiara 
Published: June 2022

AbstractAlthough there are several studies reporting the beneficial role of sports in immigrant health, more research is needed to understand whether and how these activities can guide the psychological sense of community (SOC) and well‐being outcomes. This study aims at exploring how sport participation among immigrants contributes to developing their SOC and subjective well‐being. We analyzed the experiences of 17 immigrants participating in Balon Mundial (BM), an annual multicultural football tournament in Turin (Italy). A thematic deductive theory‐driven analysis was implemented based on in‐depth interviews. BM developed a psychological SOC by providing immigrants with a safe space—based on norms of accessibility and fair play—to mutually share traditions while forming positive and trusting bonds. All these dimensions of the tournament were connected to an enhancement of immigrants' subjective well‐being in terms of happiness, self‐care, sense of acceptance and cultural intelligence. Sport participation can sustain immigrants' psychological SOC and subjective well‐being under specific conditions: (a) when norms are developed based on inclusion; and (b) when a shared goal and history are built among participants.
Design, implementation, and evaluation of community health worker training programs in Latinx communities: A scoping review
Authors: Lee Christina N. , Matthew Rebecca A. , Orpinas Pamela 
Published: June 2022

AbstractThis review examines the current reporting trends of program design, implementation, and evaluation of training programs for Latinx community health workers. Five scholarly databases were searched using a scoping review methodology to identify articles describing training programs for Latinx community health workers. The timeframe was 2009 to 2021. We identified 273 articles, with 59 meeting inclusion criteria. Researchers thematically coded the articles to identify reporting strategies related to program design, implementation, and evaluation. Findings suggest a lack of consensus in reporting elements critical to program resources, instructor qualifications, frequency and length of training implementation, theoretical background, and pedagogical tools associated with the training program. We offer detailed reporting recommendations of community health worker training programs to support the consistent dissemination of promising practices and facilitate the initiation of new programs for Latinx community health workers.
The birth weight of macrosomia influence the accuracy of ultrasound estimation of fetal weight at term
Authors: Song JinShuang , Liu JingHua , Liu Li , Jiang Ying , Zheng HongPing , Ke Hualing , Yang LiLi , Zhang ZongYu 
Published: June 2022

AbstractObjectiveTo evaluate and analyze the accuracy of ultrasound estimation of the fetal weight of Macrosomia at term.MethodThe instruments used were α6(Aloka; Japan) color Doppler ultrasound imagers, and vinno 80 (feieno; China) with a frequency of 3.5 MHz. The formula used to calculate the estimated fetal birth weight (EFW) was that proposed by Hadlock et al. (Hadlock 2). The biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), and femur length (FL) measurements were performed strictly following the practice guidelines. Detailed measurement standards are shown in the figure and the table in the text. Macrosomia is typically defined as a birth weight above the 90th percentile for gestational age or >4000 g.Two indexes were used to calculate the error between EFW and birth weight (BW): Simple error (SE = BW − EFW); Absolute percentage error (APE, which reflects this percentage in absolute value, percentage error [PE = SE/BW] × 100). In order to better evaluate the measurement results, we made the following definitions: 1. When APE > 15%, the measurement deviation is significant. 2. The ratio of those cases with APE > 15% to the total number of cases measured by a sonographer was greater than 20%, indicating that the sonographer was prone to significant measurement deviation.ResultA total of 374 cases were analyzed. The mean maternal age was 31.48 (±15.93) years. Each pregnant woman carries only one fetus. The mean gestational age at delivery was 39.93 (±0.84) weeks. There were 245 male infants (65.5%), 129 female infants (34.5%), 214 cesarean section (57.2%), and 160 vaginal delivery (42.7%). 339 cases (90.64%) were estimated to be lower than the actual BW. The estimated weight was higher than the actual weight in 35 cases, accounting for 9.36%.The APE>15% in 56 cases, accounting for 14.97%. The accuracy of estimated fetal weight was closely related to the BW of the fetus and had no significant correlation with the seniority of the physician, the gender of the fetus, and the fetal position.ConclusionStudies on macrosomia have shown that the BW of macrosomia tends to be underestimated, which is also reflected in the results of this study. The accuracy of estimated fetal weight still needs to be improved. Our study found that the accuracy of estimated fetal weight was closely related to the BW of the fetus and had no significant correlation with the seniority of the physician, the gender of the fetus, and the fetal position. The correlation between the section and calculation formula on the measurement accuracy needs to be studied. Through systematic data analysis, we can find the doctors whose measurements are relatively inaccurate in our department and carry out targeted quality control to improve the measurement accuracy.
Foliar micromorphology of selected medicinal Lamiaceae taxa and their taxonomic implication using scanning electron microscopy
Authors: Zaman Wajid , Ullah Fazal , Parmar Gaurav , Saqib Saddam , Ayaz Asma , Park SeonJoo 
Published: June 2022

AbstractIn this research, 25 medicinally used Lamiaceae species belonging to 20 genera have been studied and identified for the nine disorders. We used scanning electron microscopy (SEM) for qualitative and quantitative morphological character identification. The micromorphological characters observed here were important for distinguishing the studied taxa. The highest medicinal values were reported forVitex negundoandScutellaria baicalensisfor all considered categories except urinary and otorhinolaryngology disorders. The foliar epidermal anatomical characteristics revealed that the micromorphological features of the Lamiaceae species provide taxonomically significant and accurate identification information to delimitate the family species. Moreover, we focused on both qualitative (epidermal cell shape, stomata type, stomatal pore shape, subsidiary cell shape, glandular trichomes, and non‐glandular trichome shape) as well as quantitative features (epidermal cell size, stomata size, stomatal pore size, subsidiary cell size, and trichomes size). The trichomes diversity was different in most species' on adaxial and abaxial surfaces. In most species, anomocytic stomata were observed, but other types such as diacytic, paracytic, and tetracytic type stomata were also examined. The diverse pattern of anatomical characters suggests that the studied taxa provide insight evidence for the taxonomic observation of the Traditional Chinese Medicinal plants from the Lamiaceae. This work sets an avenue for future research and taxonomic exploration of medicinal flora through microscopic investigations.Research HighlightsThis research offers a thorough microscopic identification of the family Lamiaceae.Taxonomic information on the trichome characters and types for the accurate authentication.Qualitative and quantitative characterization of 25 medicinally used Lamiaceae taxa.
Identification of storage conditions stabilizing extracellular vesicles preparations
Authors: Görgens André , Corso Giulia , Hagey Daniel W. , Jawad Wiklander Rim , Gustafsson Manuela O. , Felldin Ulrika , Lee Yi , Bostancioglu R. Beklem , Sork Helena , Liang Xiuming , Zheng Wenyi , Mohammad Dara K. , van de Wakker Simonides I. , Vader Pieter , Zickler Antje M. , Mamand Doste R. , Ma Li , Holme Margaret N. , Stevens Molly M. , Wiklander Oscar P. B. , EL Andaloussi Samir 
Published: June 2022

AbstractExtracellular vesicles (EVs) play a key role in many physiological and pathophysiological processes and hold great potential for therapeutic and diagnostic use. Despite significant advances within the last decade, the key issue of EV storage stability remains unresolved and under investigated. Here, we aimed to identify storage conditions stabilizing EVs and comprehensively compared the impact of various storage buffer formulations at different temperatures on EVs derived from different cellular sources for up to 2 years. EV features including concentration, diameter, surface protein profile and nucleic acid contents were assessed by complementary methods, and engineered EVs containing fluorophores or functionalized surface proteins were utilized to compare cellular uptake and ligand binding. We show that storing EVs in PBS over time leads to drastically reduced recovery particularly for pure EV samples at all temperatures tested, starting already within days. We further report that using PBS as diluent was found to result in severely reduced EV recovery rates already within minutes. Several of the tested new buffer conditions largely prevented the observed effects, the lead candidate being PBS supplemented with human albumin and trehalose (PBS‐HAT). We report that PBS‐HAT buffer facilitates clearly improved short‐term and long‐term EV preservation for samples stored at ‐80°C, stability throughout several freeze‐thaw cycles, and drastically improved EV recovery when using a diluent for EV samples for downstream applications.
Ascorbate peroxidase‐mediated in situ labelling of proteins in secreted exosomes
Authors: Lee Byung Rho , Lee Tae Jin , Oh Sekyung , Li Chenglong , Song Jin‐Hyuk A , Marshall Brendan , Zhi Wenbo , Kwon Sang‐Ho 
Published: June 2022

AbstractThe extracellular vesicle exosome mediates intercellular communication by transporting macromolecules such as proteins and ribonucleic acids (RNAs). Determining cargo contents with high accuracy will help decipher the biological processes that exosomes mediate in various contexts. Existing methods for probing exosome cargo molecules rely on a prior exosome isolation procedure. Here we report an in situ labelling approach for exosome cargo identification, which bypasses the exosome isolation steps. In this methodology, a variant of the engineered ascorbate peroxidase APEX, fused to an exosome cargo protein such as CD63, is expressed specifically in exosome‐generating vesicles in live cells or in secreted exosomes in the conditioned medium, to induce biotinylation of the proteins in the vicinity of the APEX variant for a short period of time. Mass spectrometry analysis of the proteins biotinylated by this approach in exosomes secreted by kidney proximal tubule‐derived cells reveals that oxidative stress can cause ribosomal proteins to accumulate in an exosome subpopulation that contains the CD63‐fused APEX variant.
Paying attention to each other. An essay on the transnational intersections of industrial economy, subjectivity, and governance in East Germany's social‐psychological training
Authors: Lehmbrock Verena 
Published: June 2022

AbstractThis article examines a little‐known chapter both in the history of socialist labor relations and the history of psychology: Social Psychological Training (SPT) for industrial leaders in the German Democratic Republic (GDR). Based on previously untapped archival sources, it uncovers the transnational genesis of SPT and its intricate relationships with Western “therapeutic culture” of the 1970s. Governmental perspectives are addressed, as well as the level of individual appropriation of SPT and possible unintended side effects of techniques that were drawn from the social psychological and therapeutical fields. This case study helps to explore the functions of psychological expertise in authoritarian political contexts, as well as the polyvalence of group methods of change, the effects of which could turn out repressive as well as liberating on both sides of the Iron Curtain. The history of SPT solicits a polycentric view on therapeutic culture, capturing its diverse manifestations and interconnections between different societies and political economies.