bluuebunny/crossref_metadata_2025_split huggingface dataset:
If extraterrestrial intelligence exists, it is unable to recognize humans as intelligent beings
Authors: Szocik Konrad , Abylkasymova Rakhat 
Published: May 2022

AbstractIn this paper we consider a scenario in which Carl Sagan's Copernican principle is more likely than its negation. Thus, assuming that the existence of an extraterrestrial intelligence (ETI) is reasonably likely, the paper considers the possibility of an ETI that is unable to recognize humans as intelligent beings. The paper presents the rationale for such an assumption. It also discusses the possible consequences for humanity of such a scenario. In this paper, we argue why the scenario under discussion is actually more positive for humanity than a scenario in which ETI would be capable of recognizing humanity as an intelligent species. We also point to feminist approaches to SETI issues exposing the role played by the specific evolutionary and developmental context of potential ETI.
STAI-Anxiety and STAI-Depression Revisited
Authors: du Rocher Andrew R. , Pickering Alan D. 
Published: May 2022

Abstract. The State-Trait Anxiety Inventory (STAI) is widely used to measure anxiety in academic, psychiatric, and medical settings. However, it has been proposed that the trait scale does not measure pure anxiety but contains subscales that measure either anxiety or depression. As this may have implications for the interpretation of research, we investigated the differential correlates of these two subscales. Participants ( N = 171; Mage = 23.6 years) completed measures of attentional control (attentional focusing; attentional shifting), behavioral approach sensitivity (BAS), trait anger, and interpersonal fear. STAI-anxiety was predicted by interpersonal fear, and trait anger when STAI-depression was held constant. By contrast, STAI-depression was predicted by BAS and attentional shifting when STAI-anxiety was held constant. To further illustrate the functional significance of these results, we reanalyzed a published study that originally showed that total STAI scores predicted affective cognitive control in the emotional face Stroop task. Results showed that STAI-anxiety and STAI-depression differentially predicted the cognitive control of distraction. The significance of our results is discussed in relation to interpreting the STAI in academic and neuropsychiatric/clinical settings.
Subduction, Underplating, and Return Flow Recorded in the Cycladic Blueschist Unit Exposed on Syros, Greece
Authors: Kotowski Alissa J. , Cisneros Miguel , Behr Whitney M. , Stockli Daniel F. , Soukis Konstantinos , Barnes Jaime D. , Ortega‐Arroyo Daniel 
Published: May 2022

AbstractExhumed high‐pressure/low‐temperature (HP/LT) metamorphic rocks provide insights into deep (∼20–70 km) subduction interface dynamics. On Syros Island (Cyclades, Greece), the Cycladic Blueschist Unit preserves blueschist‐to‐eclogite facies oceanic‐ and continental‐affinity rocks that record the structural and thermal evolution linked to Eocene subduction. Despite decades of research, the metamorphic and deformation history (P‐T‐D) and timing of subduction and exhumation are matters of ongoing discussion. We suggest that Syros comprises three coherent tectonic slices and that each slice underwent subduction, underplating, and syn‐subduction return flow along similar P‐T trajectories, but at progressively younger times. Subduction and exhumation are distinguished by lineations and ductile fold axis orientations, and are kinematically consistent with previous studies that document top‐to‐the‐S‐SW shear (prograde‐to‐peak subduction), top‐to‐the‐NE shear (blueschist facies exhumation), and then E‐W coaxial stretching (greenschist facies exhumation). Amphibole zonations record cooling during decompression, indicating return flow above a cold slab. Multi‐mineral Rb‐Sr isochrons and compiled metamorphic geochronology show that the three slices record distinct stages of peak subduction (53–52, ∼50, and 45 Ma) that young with structural depth. Retrograde blueschist and greenschist facies fabrics span ∼50–40 and ∼43–20 Ma, respectively, and also young with structural depth. Synthesized data sets support a revised tectonic framework for Syros, involving subduction of structurally distinct coherent slices and simultaneous return flow of previously accreted tectonic slices in the subduction channel shear zone. Distributed, ductile, dominantly coaxial return flow in an Eocene‐Oligocene subduction channel proceeded at rates of ∼1.5–5 mm/yr and accommodated ∼80% of the total exhumation of this HP/LT complex.
Representation Uncertainty in the Earth Sciences
Authors: Bulgin C. E. , Thomas C. M. , Waller J. A. , Woolliams E. R. 
Published: May 2022

AbstractThe first Joint Workshop on Representation Uncertainty in the Earth Sciences was held in March 2021. This brought together the Earth observation, data assimilation and forecast verification and post‐processing communities, alongside metrologists to discuss the definition and quantification of representation uncertainty within the Earth sciences. The aim of the workshop was to facilitate cross‐disciplinary discussion, establishing where existing methodologies could be shared and to foster future collaboration. A key outcome of the workshop was a working definition of representation uncertainty applicable across all the Earth science communities, which is presented in this white paper. The cross‐disciplinary discussions at the workshop highlighted the need for scientists to work with metrologists to establish a common vocabulary for uncertainties, accessible to Earth science applications. Further recommendations included regular workshops to discuss progress in defining and quantifying representation uncertainty and awareness of cross‐disciplinary funding opportunities to further address representation uncertainty issues.
Automatic Mapping of Small Lunar Impact Craters Using LRO‐NAC Images
Authors: Fairweather J. H. , Lagain A. , Servis K. , Benedix G. K. , Kumar S. S. , Bland P. A. 
Published: May 2022

AbstractImpact craters are the most common feature on the Moon’s surface. Crater size–frequency distributions provide critical insight into the timing of geological events, surface erosion rates, and impact fluxes. The impact crater size–frequency follows a power law (meter‐sized craters are a few orders of magnitude more numerous than kilometric ones), making it tedious to manually measure all the craters within an area to the smallest sizes. We can bridge this gap by using a machine learning algorithm. We adapted a Crater Detection Algorithm to work on the highest resolution lunar image data set (Lunar Reconnaissance Orbiter‐Narrow‐Angle Camera [NAC] images). We describe the retraining and application of the detection model to preprocessed NAC images and discussed the accuracy of the resulting crater detections. We evaluated the model by assessing the results across six NAC images, each covering a different lunar area at differing lighting conditions. We present the model’s average true positive rate for small impact craters (down to 20 m in diameter) is 93%. The model does display a 15% overestimation in calculated crater diameters. The presented crater detection model shows acceptable performance on NAC images with incidence angles ranging between ∼50° and ∼70° and can be applied to many lunar sites independent to morphology.
Hurricane‐Like Vortices in Conditionally Unstable Moist Convection
Authors: Chien Mu‐Hua , Pauluis Olivier M. , Almgren Ann S. 
Published: May 2022

AbstractThis study investigates the emergence of hurricane‐like vortices in idealized simulations of rotating moist convection. A Boussinesq atmosphere with simplified thermodynamics for phase transitions is forced by prescribing the temperature and humidity at the upper and lower boundaries. The governing equations are solved numerically using a variable‐density incompressible Navier‐Stokes solver with adaptive mesh refinement to explore the behavior of moist convection under a broad range of conditions. In the absence of rotation, convection aggregates into active patches separated by large unsaturated regions. Rotation modulates this statistical equilibrium state so that the self‐aggregated convection organizes hurricane‐like vortices. The warm and saturated air converges to the center of the vortices, and the latent heat released through the upwelling, forms the warm core structure. These hurricane‐like vortices share characteristics similar to tropical cyclones in the earth's atmosphere. The hurricane‐like vortices occur under conditionally unstable conditions where the potential energy given at the boundaries is large enough, corresponding to a moderate rate of rotation. This regime shares many similar characteristics to the tropical atmosphere indicating that the formation of intense meso‐scale vortices is a general characteristic of rotating moist convection. The model used here does not include any interactions with radiation, wind‐evaporation feedback, or cloud microphysics, indicating that, while these processes may be relevant for tropical cyclogenesis in the Earth atmosphere, they are not its primary cause. Instead, our results confirm that the formation and maintenance of hurricane‐like vortices involve a combination of atmospheric dynamics under the presence of rotation and of phase transitions.
Analysis of Features in a Sliding Threshold of Observation for Numeric Evaluation (STONE) Curve
Authors: Liemohn Michael W. , Adam Joshua G. , Ganushkina Natalia Yu 
Published: May 2022

AbstractWe apply idealized scatterplot distributions to the sliding threshold of observation for numeric evaluation (STONE) curve, a new model assessment metric, to examine the relationship between the STONE curve and the underlying point‐spread distribution. The STONE curve is based on the relative operating characteristic (ROC) curve but is developed to work with a continuous‐valued set of observations, sweeping both the observed and modeled event identification threshold simultaneously. This is particularly useful for model predictions of time series data as is the case for much of terrestrial weather and space weather. The identical sweep of both the model and observational thresholds results in changes to both the modeled and observed event states as the quadrant boundaries shift. The changes in a data‐model pair's event status result in nonmonotonic features to appear in the STONE curve when compared to an ROC curve for the same observational and model data sets. Such features reveal characteristics in the underlying distributions of the data and model values. Many idealized data sets were created with known distributions, connecting certain scatterplot features to distinct STONE curve signatures. A comprehensive suite of feature‐signature combinations is presented, including their relationship to several other metrics. It is shown that nonmonotonic features appear if a local spread is more than 0.2 of the full domain or if a local bias is more than half of the local spread. The example of real‐time plasma sheet electron modeling is used to show the usefulness of this technique, especially in combination with other metrics.
Progress in osteoarthritis research by the National Natural Science Foundation of China
Authors: Li Yusheng , Xie Wenqing , Xiao Wenfeng , Dou Dou 
Published: May 2022

AbstractOsteoarthritis (OA) in China is gradually becoming an important scientific research area that has had a significant impact on research and development (R&D) activities in the OA field worldwide. This article summarizes the R&D progress related to OA in China in recent years. The National Natural Science Foundation of China (NSFC) is a national funding institution for basic research and plays a critical role in promoting and supporting Chinese scholars’ R&D activities. We collected and analyzed information on NSFC funding in the field of OA from 2010 to 2019, including the amount, the level and the program categories of the funded projects. The data fully demonstrate the important and positive role of the NSFC in supporting free exploration, cultivating research teams and young talent, and boosting OA R&D. In this article, we outline and discuss hot topics in focused areas, key advances in this field and the prospects for progress in OA research in China.
Onasemnogene abeparvovec gene replacement therapy for the treatment of spinal muscular atrophy: a real-world observational study
Authors: Bitetti Ilaria , Lanzara Valentina , Margiotta Giovanna , Varone Antonio 
Published: May 2022

AbstractSpinal muscular atrophy (SMA) is a genetically inherited recessive neuromuscular disease that causes muscular atrophy and weakness. Onasemnogene abeparvovec (formerly AVXS-101, Zolgensma®, Novartis) is a targeted therapy approved to treat patients with SMA in >40 countries worldwide. This study describes the clinical efficacy and tolerability of gene replacement therapy with onasemnogene abeparvovec over a 3-month period in 9 SMA type 1 patients aged 1.7–48 months, with 7 patients on stable nusinersen (i.e., had received all four nusinersen loading doses before inclusion in this study). Liver function (alanine aminotransferase, aspartate aminotransferase, total bilirubin), troponin I, platelet counts, creatinine levels, and motor function (CHOP-INTEND) were monitored. For the seven patients on stable nusinersen, the median baseline CHOP-INTEND score increased significantly during nusinersen treatment (Wilcoxon signed-rank testp = 0.018) and at 3 months after switching to onasemnogene abeparvovec (Wilcoxon signed-rank testp = 0.0467). We also identified two patients who responded poorly to nusinersen but showed the largest increase in baseline CHOP-INTEND scores at 1 and 3 months after switching, which could suggest that poor responders to nusinersen may respond favorably to onasemnogene abeparvovec. No unknown adverse events occurred. One patient developed moderate/severe thrombocytopenia 1 week after onasemnogene abeparvovec administration that resolved after treatment. Our study suggests the possibility of a change in the dynamic of CHOP-INTEND for patients who respond poorly to nusinersen after switching therapy to onasemnogene abeparvovec. Alternatively, patient age at treatment initiation may impact the response to onasemnogene abeparvovec. Testing in larger patient populations must be undertaken to assess the plausibility of these hypotheses.
Mothers with higher twinning propensity had lower fertility in pre-industrial Europe
Authors: Rickard Ian J. , Vullioud Colin , Rousset François , Postma Erik , Helle Samuli , Lummaa Virpi , Kylli Ritva , Pettay Jenni E. , Røskaft Eivin , Skjærvø Gine R. , Störmer Charlotte , Voland Eckart , Waldvogel Dominique , Courtiol Alexandre 
Published: May 2022

AbstractHistorically, mothers producing twins gave birth, on average, more often than non-twinners. This observation has been interpreted as twinners having higher intrinsic fertility – a tendency to conceive easily irrespective of age and other factors – which has shaped both hypotheses about why twinning persists and varies across populations, and the design of medical studies on female fertility. Here we show in >20k pre-industrial European mothers that this interpretation results from an ecological fallacy: twinners had more births not due to higher intrinsic fertility, but because mothers that gave birth more accumulated more opportunities to produce twins. Controlling for variation in the exposure to the risk of twinning reveals that mothers with higher twinning propensity – a physiological predisposition to producing twins – had fewer births, and when twin mortality was high, fewer offspring reaching adulthood. Twinning rates may thus be driven by variation in its mortality costs, rather than variation in intrinsic fertility.
Auditory processing remains sensitive to environmental experience during adolescence in a rodent model
Authors: Anbuhl Kelsey L. , Yao Justin D. , Hotz Robert A. , Mowery Todd M. , Sanes Dan H. 
Published: May 2022

AbstractElevated neural plasticity during development contributes to dramatic improvements in perceptual, motor, and cognitive skills. However, malleable neural circuits are vulnerable to environmental influences that may disrupt behavioral maturation. While these risks are well-established prior to sexual maturity (i.e., critical periods), the degree of neural vulnerability during adolescence remains uncertain. Here, we induce transient hearing loss (HL) spanning adolescence in gerbils, and ask whether behavioral and neural maturation are disrupted. We find that adolescent HL causes a significant perceptual deficit that can be attributed to degraded auditory cortex processing, as assessed with wireless single neuron recordings and within-session population-level analyses. Finally, auditory cortex brain slices from adolescent HL animals reveal synaptic deficits that are distinct from those typically observed after critical period deprivation. Taken together, these results show that diminished adolescent sensory experience can cause long-lasting behavioral deficits that originate, in part, from a dysfunctional cortical circuit.
Proton stopping measurements at low velocity in warm dense carbon
Authors: Malko S. , Cayzac W. , Ospina-Bohórquez V. , Bhutwala K. , Bailly-Grandvaux M. , McGuffey C. , Fedosejevs R. , Vaisseau X. , Tauschwitz An. , Apiñaniz J. I. , De Luis Blanco D. , Gatti G. , Huault M. , Hernandez J. A. Perez , Hu S. X. , White A. J. , Collins L. A. , Nichols K. , Neumayer P. , Faussurier G. , Vorberger J. , Prestopino G. , Verona C. , Santos J. J. , Batani D. , Beg F. N. , Roso L. , Volpe L. 
Published: May 2022

AbstractIon stopping in warm dense matter is a process of fundamental importance for the understanding of the properties of dense plasmas, the realization and the interpretation of experiments involving ion-beam-heated warm dense matter samples, and for inertial confinement fusion research. The theoretical description of the ion stopping power in warm dense matter is difficult notably due to electron coupling and degeneracy, and measurements are still largely missing. In particular, the low-velocity stopping range, that features the largest modelling uncertainties, remains virtually unexplored. Here, we report proton energy-loss measurements in warm dense plasma at unprecedented low projectile velocities. Our energy-loss data, combined with a precise target characterization based on plasma-emission measurements using two independent spectroscopy diagnostics, demonstrate a significant deviation of the stopping power from classical models in this regime. In particular, we show that our results are in closest agreement with recent first-principles simulations based on time-dependent density functional theory.
An in vivo gene amplification system for high level expression in Saccharomyces cerevisiae
Authors: Peng Bingyin , Esquirol Lygie , Lu Zeyu , Shen Qianyi , Cheah Li Chen , Howard Christopher B. , Scott Colin , Trau Matt , Dumsday Geoff , Vickers Claudia E. 
Published: May 2022

AbstractBottlenecks in metabolic pathways due to insufficient gene expression levels remain a significant problem for industrial bioproduction using microbial cell factories. Increasing gene dosage can overcome these bottlenecks, but current approaches suffer from numerous drawbacks. Here, we describe HapAmp, a method that uses haploinsufficiency as evolutionary force to drive in vivo gene amplification. HapAmp enables efficient, titratable, and stable integration of heterologous gene copies, delivering up to 47 copies onto the yeast genome. The method is exemplified in metabolic engineering to significantly improve production of the sesquiterpene nerolidol, the monoterpene limonene, and the tetraterpene lycopene. Limonene titre is improved by 20-fold in a single engineering step, delivering ∼1 g L−1 in the flask cultivation. We also show a significant increase in heterologous protein production in yeast. HapAmp is an efficient approach to unlock metabolic bottlenecks rapidly for development of microbial cell factories.
Development of a stable antibody production system utilizing an Hspa5 promoter in CHO cells
Authors: Tanemura Hiroki , Masuda Kenji , Okumura Takeshi , Takagi Eri , Kajihara Daisuke , Kakihara Hirofumi , Nonaka Koichi , Ushioda Ryo 
Published: May 2022

AbstractChinese hamster ovary (CHO) cells are widely used for manufacturing antibody drugs. We attempted to clone a novel high-expression promoter for producing monoclonal antibodies (mAbs) based on transcriptome analysis to enhance the transcriptional abundance of mAb genes. The efficacy of conventional promoters such as CMV and hEF1α decrease in the latter phase of fed-batch cell culture. To overcome this, we screened genes whose expression was maintained or increased throughout the culture period. Since CHO cells have diverse genetic expression depending on the selected clone and culture medium, transcriptome analysis was performed on multiple clones and culture media anticipated to be used in mAb manufacturing. We thus acquired the Hspa5 promoter as a novel high-expression promoter, which uniquely enables mAb productivity per cell to improve late in the culture period. Productivity also improved for various IgG subclasses under Hspa5 promoter control, indicating this promoter’s potential universal value for mAb production. Finally, it was suggested that mAb production with this promoter is correlated with the transcription levels of endoplasmic reticulum stress-related genes. Therefore, mAb production utilizing the Hspa5 promoter might be a new method for maintaining protein homeostasis and achieving stable expression of introduced mAb genes during fed-batch culture.