bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational study of the dissolution of cellulose into single chains: the role of the solvent and agitation
Authors: Bering Eivind , Torstensen Jonathan Ø. , Lervik Anders , de Wijn Astrid S. 
Published: January 2022

Abstract
We investigate the dissolution mechanism of cellulose using molecular dynamics simulations in both water and a mixture solvent consisting of water with Na$$^+$$

+

, OH$$^-$$

-

and urea. As a first computational study of its kind, we apply periodic external forces that mimic agitation of the suspension. Without the agitation, the bundles do not dissolve, neither in water nor solvent. In the solvent mixture the bundle swells with significant amounts of urea entering the bundle, as well as more water than in the bundles subjected to pure water. We also find that the mixture solution stabilizes cellulose sheets, while in water these immediately collapse into bundles. Under agitation the bundles dissolve more easily in the solvent mixture than in water, where sheets of cellulose remain that are bound together through hydrophobic interactions. Our findings highlight the importance of urea in the solvent, as well as the hydrophobic interactions, and are consistent with experimental results.

Graphical abstract
On a primal-dual Newton proximal method for convex quadratic programs
Authors: De Marchi Alberto 
Published: January 2022

AbstractThis paper introduces QPDO, a primal-dual method for convex quadratic programs which builds upon and weaves together the proximal point algorithm and a damped semismooth Newton method. The outer proximal regularization yields a numerically stable method, and we interpret the proximal operator as the unconstrained minimization of the primal-dual proximal augmented Lagrangian function. This allows the inner Newton scheme to exploit sparse symmetric linear solvers and multi-rank factorization updates. Moreover, the linear systems are always solvable independently from the problem data and exact linesearch can be performed. The proposed method can handle degenerate problems, provides a mechanism for infeasibility detection, and can exploit warm starting, while requiring only convexity. We present details of our open-source C implementation and report on numerical results against state-of-the-art solvers. QPDO proves to be a simple, robust, and efficient numerical method for convex quadratic programming.
Beyond categories: dynamic qualitative analysis of visuospatial representation in arithmetic
Authors: Finesilver Carla 
Published: January 2022

AbstractVisuospatial representations of numbers and their relationships are widely used in mathematics education. These include drawn images, models constructed with concrete manipulatives, enactive/embodied forms, computer graphics, and more. This paper addresses the analytical limitations and ethical implications of methodologies that use broad categorizations of representations and argues the benefits of dynamic qualitative analysis of arithmetical-representational strategy across multiple semi-independent aspects of display, calculation, and interaction. It proposes an alternative methodological approach combining the structured organization of classification with the detailed nuance of description and describes a systematic but flexible framework for analysing nonstandard visuospatial representations of early arithmetic. This approach is intended for use by researchers or practitioners, for interpretation of multimodal and nonstandard visuospatial representations, and for identification of small differences in learners’ developing arithmetical-representational strategies, including changes over time. Application is illustrated using selected data from a microanalytic study of struggling students’ multiplication and division in scenario tasks.
Two sides of the same coin: increasing material extraction rates and social environmental conflicts in Mexico
Authors: Tetreault Darcy 
Published: January 2022

AbstractThis article seeks to explain the multiplication of social environmental conflicts in Mexico as a consequence of expanding and intensifying extractive activities. It examines how the Mexican state has provided private and foreign capital greater access to the country’s natural resources in the transition from state-led import-substituting industrialization to export-oriented market-led development. This, it argues, has led to accelerating material extraction rates in the context of rising global demand for primary commodities; while the negative environmental and social impacts have in turn led to a growing number of conflicts involving the inhabitants of directly affected rural communities, who organize to resist. Based on standardized procedures for material flow analysis, it presents the results of an investigation into the domestic extraction rates of minerals, metal ores, biomass, and fossil fuels from Mexico, between 1990 and 2018. It finds that domestic extraction rates increased significantly during this period, with the exception of fossil fuels, which peaked in 2006, declining thereafter due to the exhaustion of the country’s most important oil reserves. The evolution of domestic extraction rates is juxtaposed with the emergence of related social environmental conflicts by drawing on multiple databases of conflicts around extractive activities in Mexico.
Isolated Objects and Their Evolution: A Derivation of the Propagator’s Path Integral for Spinless Elementary Particles
Authors: Napoletani Domenico , Struppa Daniele C. 
Published: January 2022

AbstractWe formalize the notion of isolated objects (units), and we build a consistent theory to describe their evolution and interaction. We further introduce a notion of indistinguishability of distinct spacetime paths of a unit, for which the evolution of the state variables of the unit is the same, and a generalization of the equivalence principle based on indistinguishability. Under a time reversal condition on the whole set of indistinguishable paths of a unit, we show that the quantization of motion of spinless elementary particles in a general potential field can be derived in this framework, in the limiting case of weak fields and low velocities. Extrapolating this approach to include weak relativistic effects, we explore possible experimental consequences. We conclude by suggesting a primitive ontology for the theory of isolated objects.
A Multi-Criteria Approach to Decision Making in Broadband Technology Selection
Authors: Araújo Marco , Ekenberg Love , Danielson Mats , Confraria João 
Published: January 2022

AbstractA new European Union regulatory framework for the telecom sector has been under a process of transposition to national laws by its member states that should have been completed by the end of 2020, notwithstanding some delays. A core purpose of the regulatory framework is to guarantee that most citizens will have access to very fast Internet connections, capable of 100 Mbps download link speed, regardless of where they live. According to this new framework, in areas where the market does not deliver, governments are to launch public tenders for the deployment, maintenance, and operations of network infrastructure as well as services, and public funds should be used to support the deployment of these broadband networks in less densely populated areas. Needless to say, public tenders of this nature are subject to different criteria when it comes to candidate evaluation. In this paper, we present a decision model for the selection of operators to deploy and maintain broadband networks in scarcely populated areas, taking into consideration infrastructure costs, the technical quality offered by the solutions, and the credibility of the candidates. We suggest an integrated multi-stakeholder multi-criteria approach and demonstrate how it can be used in this complex area and find that in the example provided, taking a relevant set of criteria into the analysis, optical fibre networks hold much higher chances to be used in these public tenders compared to networks based on the broadly favoured 5G technology.
Impact of design thinking in higher education: a multi-actor perspective on problem solving and creativity
Authors: Guaman-Quintanilla Sharon , Everaert Patricia , Chiluiza Katherine , Valcke Martin 
Published: January 2022

AbstractThis study investigates the effects of using design thinking on students’ problem solving and creativity skills, applying a constructivist learning theory. A course where students use design thinking for analyzing real problems and proposing a solution, was evaluated. The study involved 910 novice university students from different disciplines who worked in teams throughout the semester. Data were collected at three times during the semester, i.e. at the beginning (t0), in the middle (t1) and at the end (t2), after solving a short case study. Each time the problem solving and creativity skill of each student was rated by three different actors, i.e. the students themselves (self-evaluation), one peer and one teacher (facilitator). The objective of this study is to investigate whether the problem solving skills and creativity skills improved along the course, as rated by the three actors. A repeated measures ANOVA was used for the data analysis of this within-subjects design. Results show a significant improvement on students’ problem solving and creativity skills, according to the three raters. Effect sizes were also calculated; in all cases the effect sizes from t0 to t1 were larger than t1 to t2. The multi-actor perspective of this study, the adoption of reliable and valid measures and the large sample size provide robust evidence that supports the implementation of design thinking in higher education curriculum for promoting key skills such as problem solving and creativity, demanded by labor markets. Finally, a discussion that puts forward an agenda for future research is presented.
Identifying Patterns of Similarities and Differences between Gesture Production and Comprehension in Autism and Typical Development
Authors: Dimitrova Nevena , Özçalışkan Şeyda 
Published: January 2022

AbstractProduction and comprehension of gesture emerge early and are key to subsequent language development in typical development. Compared to typically developing (TD) children, children with autism spectrum disorders (ASD) exhibit difficulties and/or differences in gesture production. However, we do not yet know if gesture production either shows similar patterns to gesture comprehension across different ages and learners, or alternatively, lags behind gesture comprehension, thus mimicking a pattern akin to speech comprehension and production. In this study, we focus on the gestures produced and comprehended by a group of young TD children and children with ASD—comparable in language ability—with the goal to identify whether gesture production and comprehension follow similar patterns between ages and between learners. We elicited production of gesture in a semi-structured parent–child play and comprehension of gesture in a structured experimenter-child play across two studies. We tested whether young TD children (ages 2–4) follow a similar trajectory in their production and comprehension of gesture (Study 1) across ages, and if so, whether this alignment remains similar for verbal children with ASD (Mage = 5 years), comparable to TD children in language ability (Study 2). Our results provided evidence for similarities between gesture production and comprehension across ages and across learners, suggesting that comprehension and production of gesture form a largely integrated system of communication.
Could road constructions be more hazardous than an earthquake in terms of mass movement?
Authors: Tanyaş Hakan , Görüm Tolga , Kirschbaum Dalia , Lombardo Luigi 
Published: January 2022

AbstractRoads can have a significant impact on the frequency of mass wasting events in mountainous areas. However, characterizing the extent and pervasiveness of mass movements over time has rarely been documented due to limitations in available data sources to consistently map such events. We monitored the evolution of a road network and assessed its effect on mass movements for a 11-year window in Arhavi, Turkey. The main road construction projects run in the area are associated with a hydroelectric power plant as well as other road extension works and are clearly associated with the vast majority (90.1%) of mass movements in the area. We also notice that the overall number and size of the mass movements are much larger than in the naturally occurring comparison area. This means that the sediment load originating from the anthropogenically induced mass movements is larger than its counterpart associated with naturally occurring landslides. Notably, this extra sediment load could cause river channel aggregation, reduce accommodation space and as a consequence, it could lead to an increase in the probability and severity of flooding along the river channel. This marks a strong and negative effect of human activities on the natural course of earth surface processes. We also compare frequency-area distributions of human-induced mass movements mapped in this study and co-seismic landslide inventories from the literature. By doing so, we aim to better understand the consequences of human effects on mass movements in a comparative manner. Our findings show that the damage generated by the road construction in terms of sediment loads to river channels is compatible with the possible effect of a theoretical earthquake with a magnitude greater than Mw = 6.0.
COVID-19 Pandemic-Related Arguments in Polish Civil Litigation
Authors: Piszcz Anna 
Published: January 2022

AbstractThe aim of this paper is to analyse the legal record on civil litigation from mid-March 2020 to mid-July 2021 and examine COVID-19 pandemic-related arguments in a sample of litigated cases heard in Polish courts, more precisely 41 cases. In an attempt to establish the number and types of court cases in which such arguments have been raised, the population of individual case records was accessed electronically from the Ordinary Courts Judgments Portal (Pol. Portal Orzeczeń Sądów Powszechnych). The analysed research material consists of texts of written justifications published along with rulings of courts of the first instance in the Portal, except for texts regarding criminal cases and widely understood labour cases. This paper refers to certain theoretical aspects of argument and argumentation. Then, it sheds light on the use of COVID-19 pandemic-related arguments by the parties involved in litigation—as reported by the courts in written justifications—considering, amongst others, whether those arguments were found convincing by the courts. Based on a survey of relevant cases, an attempt was made to identify categories of COVID-19 pandemic-related arguments of the parties involved in litigation, raised in their legal submissions. Also a look into the tendencies in this regard was taken to see whether any patterns emerge and it is possible (or not) to discern different trends in the analysed phenomena.
The point of the analysis in this article is both descriptive and normative.
Transition from Oxycodone to Buprenorphine/Naloxone in a Hospitalized Patient with Sickle Cell Disease: A Case Report
Authors: Leyde Sarah , Suen Leslie , Pratt Lisa , DeFries Triveni 
Published: January 2022

AbstractBuprenorphine is increasingly used to treat pain in patients with sickle cell disease but optimal timing and approach for transitioning patients from full agonist opioids to buprenorphine is unknown. We present the case of a 22-year-old woman with sickle cell disease and acute on chronic pain who transitioned from high-dose oxycodone to buprenorphine/naloxone during a hospital stay for vaso-occlusive episode. Utilizing a microdosing approach to minimize pain and withdrawal, buprenorphine/naloxone was gradually uptitrated while she received full agonist opioids. During the transition, she experienced some withdrawal in the setting of swallowed buprenorphine/naloxone tablets, which were intended to be dosed sublingually. Nevertheless, the transition was tolerable to the patient and her pain and function significantly improved with buprenorphine treatment. This case also highlights the challenges and unique considerations that arise when providing care for the hospitalized patient who is also incarcerated.
Familiäres Mittelmeerfieber – Rolle der Interleukin-1-Blockade in der Therapie
Authors: Henes Jörg , Saur Sebastian 
Published: January 2022

ZusammenfassungDas familiäre Mittelmeerfieber (FMF) ist die häufigste autoinflammatorische Erkrankung und gehört zu den monogenetischen Fiebersyndromen. Die Erkrankung beruht auf einer Mutation desMEFV-Gens; dieses ist auf dem kurzen Arm von Chromosom 16 lokalisiert und kodiert für das Protein Pyrin. Pyrin aktiviert über mehrere Schritte eine erhöhte Ausschüttung der proinflammatorischen Zytokine Interleukin (IL)‑1β und IL‑18. Die wichtigsten Symptome sind neben dem Fieber wiederkehrende abdominelle und pleuritische Schmerzen, Gelenkschmerzen und Myalgien, Orchitiden oder auch ein erysipelartiges Exanthem. Die Standardtherapie ist bis heute Colchizin. Ca. 10–15 % der Patienten sprechen jedoch nicht ausreichend auf diese Therapie an oder vertragen die notwendige Dosierung nicht. Bei diesen Patienten und auch bei Patienten mit anhaltend hohen SAA-Werten trotz klinischer Kontrolle stehen uns heute mit den IL‑1 Inhibitoren Anakinra und Canakinumab hocheffektive Alternativen zur Verfügung.
Band-gap structure of the spectrum of the water-wave problem in a shallow canal with a periodic family of deep pools
Authors: Nazarov Sergei A. , Taskinen Jari 
Published: January 2022

AbstractWe consider the linear water-wave problem in a periodic channel $$\Pi ^h \subset {{\mathbb {R}}}^3$$

Π
h

⊂

R

3

, which is shallow except for a periodic array of deep potholes in it. Motivated by applications to surface wave propagation phenomena, we study the band-gap structure of the essential spectrum in the linear water-wave system, which includes the spectral Steklov boundary condition posed on the free water surface. We apply methods of asymptotic analysis, where the most involved step is the construction and analysis of an appropriate boundary layer in a neighborhood of the joint of the potholes with the thin part of the channel. Consequently, the existence of a spectral gap for small enough h is proven.
New Contraception Update — Annovera, Phexxi, Slynd, and Twirla
Authors: Baker Courtney C. , Chen Melissa J. 
Published: January 2022

Abstract

Purpose of Review

In this review, we discuss the efficacy, safety, and benefits of four new contraceptive products available in the USA, specifically Annovera, Phexxi, Slynd, and Twirla.

Recent Findings

Annovera is a vaginal ring releasing ethinyl estradiol and segesterone acetate that can be used for up to one year (13 cycles), offering patients an effective, user-controlled option that may improve contraceptive access for those in low-resource settings or those with barriers to retrieving monthly prescriptions; however, given limited efficacy and safety data in people with body mass index (BMI) > 29 kg/m2, clinicians may consider whether Annovera is an appropriate contraceptive method for obese patients if there are other acceptable alternatives. Phexxi prescription-only vaginal gel is a user-controlled, non-hormonal, on-demand contraceptive method that represents a novel addition to the market with its additional uses as a personal lubricant and as a potential microbicide for urogenital infection prevention. Slynd, a drospirenone-only pill, provides more flexibility for delayed or missed pills while maintaining efficacy and a more favorable bleeding profile compared with previously available progestin-only pills. Lastly, Twirla is a transdermal patch releasing ethinyl estradiol and levonorgestrel that offers users an additional option for a user-controlled, combined hormonal contraceptive method without daily dosing; however, prescription is limited to patients with BMI < 30 kg/m2 due to decreased efficacy and VTE events in people with obesity.

Summary

The addition of these products expands the available options for pregnancy prevention to address unmet contraceptive needs.
Disrupting Aotearoa New Zealand’s Curricular Consensus: From ‘World-Leading’ Curriculum to Curriculum Refresh 2007–2021
Authors: Hughson Taylor Alexander 
Published: January 2022

AbstractThis article seeks to explain how Aotearoa New Zealand moved from a consensus that the New Zealand Curriculum (NZC) should grant a high degree of autonomy to teachers, to an emerging view that it ought to be more prescriptive about content. To do this, it takes an assemblage approach to policy analysis, understanding policies as constantly evolving ‘bundles’ of divergent components temporarily woven together. The article first explores the complex intermingling of Third Way priorities, knowledge economy discourses, educational progressivism and narratives of ‘harmonious’ biculturalism which constitute the 2007 NZC. It then explores the sustained critique of the NZC from the 2015 parliamentary petition calling for compulsory teaching of the New Zealand Wars, up to the government’s 2021 ‘curriculum refresh’ announcement. It is argued that this ‘refresh’ moves to reassemble the NZC so that it accommodates a series of demands made of it in recent years, including demands the curriculum take a more active role in redressing the impact of colonisation, and demands from both business-aligned groups and academics that the curriculum become more ‘knowledge-led’.
Identification of patterns for space-time event networks
Authors: Sanabria Alan Miguel Forero , Castañeda Martha Patricia Bohorquez , Ramos Rafael Ricardo Rentería , Mateu Jorge 
Published: January 2022

AbstractThis paper provides new tools for analyzing spatio-temporal event networks. We build time series of directed event networks for a set of spatial distances, and based on scan-statistics, the spatial distance that generates the strongest change of event network connections is chosen. In addition, we propose an empirical random network event generator to detect significant motifs throughout time. This generator preserves the spatial configuration but randomizes the order of the occurrence of events. To prevent the large number of links from masking the count of motifs, we propose using standardized counts of motifs at each time slot. Our methodology is able to detect interaction radius in space, build time series of networks, and describe changes in its topology over time, by means of identification of different types of motifs that allows for the understanding of the spatio-temporal dynamics of the phenomena. We illustrate our methodology by analyzing thefts occurred in Medellín (Colombia) between the years 2003 and 2015.