bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the effect of an online self-compassion for weight management (SC4WM) intervention on self-compassion, eating behaviour, physical activity and body weight in adults seeking to manage weight: protocol for a randomised controlled trial
Authors: Brenton-Peters Jennifer M , Consedine Nathan S , Cavadino Alana , Roy Rajshri , Serlachius Anna Sofia 
Published: February 2022

IntroductionIndividual weight management, defined as engaging in behaviours to maintain or lose weight, can improve health and well-being. However, numerous factors influence weight management outcomes, such as genetics, biology, stress, the social and physical environment. Consequently, weight management can be hard. Self-compassion, described as treating oneself kindly in times of failure or distress, has shown promise in improving weight management outcomes. The objectives of this study are twofold: (1) to examine the efficacy of an online self-compassion for weight management (SC4WM) intervention coupled with an online commercial weight management programme (WW Weight Watchers reimagined) with increasing self-compassion and improving weight management outcomes (eating behaviour, physical activity and body weight) in comparison with the WW programme only and (2) to explore whether improvements in weight management outcomes are moderated by eating restraint, weight self-stigma, perceived stress and psychological coping.Methods and analysisTo achieve these objectives, 240 participants seeking to manage their weight were randomised to either an online behavioural commercial weight management programme (WW) or the online WW +SC4 WM intervention. Validated measures of self-compassion, stress, weight self-stigma, eating restraint, psychological coping and weight management outcomes were administered online at baseline, 4 weeks and at a 12-week follow-up.Ethics and disseminationEthics has been granted by the University of Auckland Health Research Ethics committee. Results will be communicated in peer-review journals, conferences and a doctoral thesis. If effective in increasing self-compassion and improving weight management outcomes, the intervention could be made more widely available to supplement behavioural weight management programmes.Trial registration numberACTRN12621000580875; Pre-results.
Evaluation of gender differences in postoperative sore throat and hoarseness following the use of Ambu AuraGain laryngeal mask: the randomised controlled LadyLAMA trial study protocol
Authors: Epp Katharina , Przybylski Uli , Luz Carla , Kriege Marc , Wittenmeier Eva , Schmidtmann Irene , Pirlich Nina 
Published: February 2022

IntroductionPostoperative sore throat (POST) is a comparatively minor but very common side effect of general anaesthesia with a supraglottic airway device. The patient considers these side effects a mirror of the quality of anaesthesia. The aims of this study are to evaluate gender-specific differences in the incidence of POST and to assess whether the effects of known risk factors vary between genders.Methods and analysisThe LadyLAMA trial is a single-centre, patient-blinded, randomised controlled trial. Consecutive patients requiring ophthalmological surgery under general anaesthesia with a second generation Ambu AuraGain laryngeal mask are randomly allocated to either cuff pressure of 45 cmH2O or cuff pressure of 60 cmH2O. We estimate the difference in POST between the genders at 20% and we hypothesised that a reduction of cuff pressure would reduce POST by 10%. A total of 800 patients will be recruited, with each subgroup including 200 patients to achieve 80% power for detecting a difference at the 5% significance level. Primary endpoints are gender differences in the incidence of POST within 24 hours postoperatively, as well as comparison of cuff pressure 45 cmH2O to 60 cmH2O with respect to POST. The main secondary objective is the effect of cuff pressure on POST stratified by gender. Further secondary endpoints are gender-specific differences in POST and hoarseness in postanaesthesia care unit (PACU) at 48 and 72 hours (or until freedom of discomfort). The parameter cuff pressure serves as key-secondary endpoint.Ethics and disseminationThe project is approved by the local ethics committee of the Medical Association of the Rhineland Palatine state (Nr. 2021-15835). The results of this study will be made available in the form of manuscripts for publication and presentations at national and international meetings.Trial registration numberNCT04915534.
Ultrasound measurements of pathological and physiological skin thickness: a scoping review protocol
Authors: Meikle Brandon , Kimble Roy M , Tyack Zephanie 
Published: February 2022

IntroductionUltrasound is a quick, safe, and non-invasive imaging method that can be used to measure skin thickness in pathological cutaneous conditions in clinical and research settings. Despite widespread use, there exists a lack of standardisation and reporting of ultrasound skin thickness measurement methods, which makes between-studies comparisons difficult. To address this, we present a scoping review protocol, which aims to determine what is and is not known about the measurement of skin and scar thickness using ultrasound in people with traumatic scars.Methods and analysisThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines and Joanna Briggs Institute scoping review methodology will be used to guide this review. Electronic database searching will be conducted in Ovid MEDLINE, Embase, Cumulative Index of Nursing and Allied Health Literature and Web of Science. No date limit will be imposed on the database searches. Records will be supplemented with searches of reference lists of included studies and grey literature in OpenGrey and Google Advanced. Screening will be conducted by two independent reviewers, and studies where ultrasound is used to measure skin and scar thickness in people with traumatic scars will be included. Data extraction will include ultrasound methods (eg, transducer orientation), psychometric properties (eg, reliability, measurement error), health service and implementation outcomes (eg, feasibility, acceptability) and factors influencing ultrasound measurement of skin thickness (eg, body location, age).Ethics and disseminationEthical approval is not required for this investigation, as published literature will form the basis of the review. The review will be published in a peer-reviewed scientific journal and is expected to result in the development of the first evidence-based and consensus-based methodological guideline for skin thickness measurement by ultrasound.
Development and use of research vignettes to collect qualitative data from healthcare professionals: a scoping review
Authors: Tremblay Dominique , Turcotte Annie , Touati Nassera , Poder Thomas G , Kilpatrick Kelley , Bilodeau Karine , Roy Mathieu , Richard Patrick O , Lessard Sylvie , Giordano Émilie 
Published: February 2022

ObjectivesTo clarify the definition of vignette-based methodology in qualitative research and to identify key elements underpinning its development and utilisation in qualitative empirical studies involving healthcare professionals.DesignScoping review according to the Joanna Briggs Institute framework and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines.Data sourcesElectronic databases: Academic Search Complete, CINAHL Plus, MEDLINE, PsycINFO and SocINDEX (January 2000–December 2020).Eligibility criteriaEmpirical studies in English or French with a qualitative design including an explicit methodological description of the development and/or use of vignettes to collect qualitative data from healthcare professionals. Titles and abstracts were screened, and full text was reviewed by pairs of researchers according to inclusion/exclusion criteria.Data extraction and synthesisData extraction included study characteristics, definition, development and utilisation of a vignette, as well as strengths, limitations and recommendations from authors of the included articles. Systematic qualitative thematic analysis was performed, followed by data matrices to display the findings according to the scoping review questions.ResultsTen articles were included. An explicit definition of vignettes was provided in only half the studies. Variations of the development process (steps, expert consultation and pretesting), data collection and analysis demonstrate opportunities for improvement in rigour and transparency of the whole research process. Most studies failed to address quality criteria of the wider qualitative design and to discuss study limitations.ConclusionsVignette-based studies in qualitative research appear promising to deepen our understanding of sensitive and challenging situations lived by healthcare professionals. However, vignettes require conceptual clarification and robust methodological guidance so that researchers can systematically plan their study. Focusing on quality criteria of qualitative design can produce stronger evidence around measures that may help healthcare professionals reflect on and learn to cope with adversity.
Vitamin K-dependent anticoagulant use and level of anticoagulation control in sub-Saharan Africa: protocol for a retrospective cohort study
Authors: Mwita Julius Chacha , Damasceno Albertino , Chillo Pilly , Ogah Okechukwu S , Cohen Karen , Oyekunle Anthony , Tefera Endale , Francis Joel Msafiri 
Published: February 2022

BackgroundGiven that vitamin K-dependent anticoagulants (VKAs) will continue to be the primary anticoagulant in Africa for a long time, understanding the quality of anticoagulation services in the continent is vital for optimising the intended benefits. Notably, a few small studies have assessed the quality of anticoagulation in sub-Saharan Africa (SSA) countries. This study will describe the current VKA use and anticoagulation control among patients in selected SSA countries.Methods and analysisWe plan to review the 2019 anticoagulation data of a cohort of 800 random patients from 19 selected clinics in Botswana, the Democratic Republic of Congo, Ethiopia, Gambia, Ghana, Mozambique, Nigeria, Tanzania and South Africa. We expect at least one participating site to enrol 100 participants in each country. Eligible participants will be those on VKAs for at least 3 months and with at least four international normalised ratio (INR) results. We will document the indications, type and duration of VKA use, sociodemographic factors, coexisting medical conditions, concurrent use of drugs that interact with warfarin and alcohol and tobacco products. The level of anticoagulation control will be determined by calculating the time-in-therapeutic range (TTR) using the Rosendaal and the Percent of INR in TTR methods. A TTR of less than 65% will define a suboptimal anticoagulation control.Ethics and disseminationThis study was approved by the Ministry of Health and Wellness Ethics Committee (HPDME13/8/1) in Botswana and local research ethics committees or institutional review boards of all participating sites. As the study collects data from existing records, sites applied for waivers of consent. We will disseminate research findings through peer-reviewed scientific publications.
Advance and future care planning: strategic approaches in Wales
Authors: Taubert Mark , Bounds Lauren 
Published: February 2022

BackgroundIn Wales, the term advance care planning now falls under the wider umbrella term ‘Future Care Planning’, which also includes patients with diminished mental capacity and their significant others, to engage in deciding and planning future care. Over the last 5 years, work has been undertaken to create education formats, resources and national documents, and this has been informed by a national Advance and Future Care Planning steering group and national conference, which included patient and carer representatives. This helped collate relevant data.AimWe outline key strategic approaches in Wales with regard to future care planning.ResultsWith data from our national conference and through feedback from stakeholders, a national repository of distinct resources, forms and education formats has been created. The approach seeks to cater for the disparate need of the Welsh population; there is not merely one format for multiple scenarios, but a choice of approaches, communication strategies and documents to suit bespoke needs.ConclusionAdvance and future care planning is an approach with many different facets. In Wales, we have found that some patients prefer a clearly set out, legally binding ‘Advance Decision to Refuse Treatment’ to guide their care, while others prefer a softer, guiding approach captured through an Advance Statement. All these formats are available to patients, carers and healthcare professionals, together with explanatory guidance notes, through a central Welsh website. Next steps involve getting a central electronic repository for these forms, which is accessible to healthcare providers and to patients.
Towards understanding specific ion effects in aqueous media using thermodiffusion
Authors: Mohanakumar Shilpa , Wiegand Simone 
Published: February 2022

Abstract
Specific ion effects play an important role in scientific and technological processes. According to Hofmeister, the influence on the hydrogen bond network depends on the ion and leads to a specific order of the ions. Also thermodiffusion the mass transport caused by a temperature gradient is very sensitive to changes of the hydrogen bond network leading to a ranking according to hydrophilicity of the salt. Hence, we investigate various salt solutions in order to compare with the Hofmeister concept. We have studied three different sodium salts in water as a function of temperature (25–45$$^\circ $$

∘

C) and concentration (0.5–5 mol kg$$^{-1}$$

-
1

) using Thermal Diffusion Forced Rayleigh Scattering (TDFRS). The three anions studied, carbonate, acetate and thiocyanate, span the entire range of the Hofmeister series from hydrophilic to hydrophobic. We compare the results with the recent measurements of the corresponding potassium salts to see to what extent the cation changes the thermodiffusion of the salt.

Graphic abstract
Risk Factor Analysis and Construction of a Prognostic Model after Percutaneous Coronary Intervention in Patients with Chronic Total Occlusion
Authors: Zhao Xia , Yuan Xian , Zhong Yi , Wang Gang 
Published: February 2022

Background and Objective. Percutaneous coronary intervention (PCI) is expansively used in the treatment of chronic total occlusion (CTO), but there is a lack of effective means to predict the prognosis of CTO patients undergoing PCI. The aim of this study was to construct a risk model that could effectively predict disease progression after PCI treatment in patients with CTO and enrich the means of clinical prediction of prognosis. Methods. The clinical data of 82 patients with CTO who underwent PCI in Lianshui County People’s Hospital were collected in this study. The patients were divided into training set (

n
=
54

) and validation set (

n
=
28

) by random sampling method. Statistical difference test was performed for clinical features of patients. Univariate and multivariate Cox regression analyses were performed to determine the risk factors affecting progression of CTO. Nomogram was used to construct a prediction model for disease progression.

C

-index was calculated, and the accuracy of the model was tested by calibration curve. Results. No statistically significant differences were incorporated in baseline characteristics of included patients (

p
>
0.05

). There were 25 patients with adverse cardiac events during follow-up in the training set and 13 in the validation set. The results of multivariate Cox regression analysis demonstrated that the important factors affecting postoperative disease progression mainly came down to age, BMI, diabetes, creatinine clearance rate, and

left

ventricular

fraction
<
40
%

. A nomogram was constructed and

C

-index was calculated. The calibration curve was then used to evaluate and predict risk model of disease progression. The result showed an internal validation

C

-index of 0.6219 and an external validation

C

-index of 0.6453, which indicated the good prediction performance of the model. Conclusion. The risk of disease progression in CTO patients treated with PCI can be effectively predicted by the risk model constructed in this study, which opens up a great possibility for enriching the means of predicting the prognosis of these patients in clinical practice.
Distinct Neural Signatures of Outcome Monitoring After Selection and Execution Errors
Authors: Mushtaq Faisal , McDougle Samuel D. , Craddock Matt P. , Parvin Darius E. , Brookes Jack , Schaefer Alexandre , Mon-Williams Mark , Taylor Jordan A. , Ivry Richard B. 
Published: February 2022

Abstract
Losing a point in tennis could result from poor shot selection or faulty stroke execution. To explore how the brain responds to these different types of errors, we examined feedback-locked EEG activity while participants completed a modified version of a standard three-armed bandit probabilistic reward task. Our task framed unrewarded outcomes as the result of either errors of selection or errors of execution. We examined whether amplitude of a medial frontal negativity (the feedback-related negativity [FRN]) was sensitive to the different forms of error attribution. Consistent with previous reports, selection errors elicited a large FRN relative to rewards, and amplitude of this signal correlated with behavioral adjustment after these errors. A different pattern was observed in response to execution errors. These outcomes produced a larger FRN, a frontocentral attenuation in activity preceding this component, and a subsequent enhanced error positivity in parietal sites. Notably, the only correlations with behavioral adjustment were with the early frontocentral attenuation and amplitude of the parietal signal; FRN differences between execution errors and rewarded trials did not correlate with subsequent changes in behavior. Our findings highlight distinct neural correlates of selection and execution error processing, providing insight into how the brain responds to the different classes of error that determine future action.
Are Trends in Convective Parameters over the United States and Europe Consistent between Reanalyses and Observations?
Authors: Pilguj Natalia , Taszarek Mateusz , Allen John T. , Hoogewind Kimberly A. 
Published: February 2022

AbstractIn this work, long-term trends in convective parameters are compared between ERA5, MERRA-2, and observed rawinsonde profiles over Europe and the United States including surrounding areas. A 39-yr record (1980–2018) with 2.07 million quality-controlled measurements from 84 stations at 0000 and 1200 UTC is used for the comparison, along with collocated reanalysis profiles. Overall, reanalyses provide signals that are similar to observations, but ERA5 features lower biases. Over Europe, agreement in the trend signal between rawinsondes and the reanalyses is better, particularly with respect to instability (lifted index), low-level moisture (mixing ratio), and 0–3-km lapse rates as compared with mixed trends in the United States. However, consistent signals for all three datasets and both domains are found for robust increases in convective inhibition (CIN), downdraft CAPE (DCAPE), and decreases in mean 0–4-km relative humidity. Despite differing trends between continents, the reanalyses capture well changes in 0–6-km wind shear and 1–3-km mean wind with modest increases in the United States and decreases in Europe. However, these changes are mostly insignificant. All datasets indicate consistent warming of almost the entire tropospheric profile, which over Europe is the fastest near ground whereas across the Great Plains it is generally between 2 and 3 km above ground level, thus contributing to increases in CIN. Results of this work show the importance of intercomparing trends between various datasets, as the limitations associated with one reanalysis or observations may lead to uncertainties and lower our confidence in how parameters are changing over time.
Impacts of Aerosols and Climate Modes on Tropical Cyclone Frequency over the North Indian Ocean: A Statistical Link Approach
Authors: Wahiduzzaman Md. , Ali Md. Arfan , Cheung Kevin , Luo Jing-Jia , Shaolei Tang , Bhaskaran Prasad K. , Yuan Chaoxia , Bilal Muhammad , Qiu Zhongfeng , Almazroui Mansour 
Published: February 2022

AbstractNorth Indian Ocean (NIO) tropical cyclone activity is strongly influenced by aerosols and climate modes. In this study, we evaluated the impact of aerosols and climate modes on modulating tropical cyclone (TC) frequency over the NIO. A statistical generalized additive model based on Poisson regression was developed to assess their relative impacts. Aerosol optical depth for different compounds simulated by the Goddard Chemistry Aerosol Radiation and Transport model, sunspot number (SN) as solar variability, and eight climate modes—Atlantic meridional mode (AMM), El Niño–Southern Oscillation (ENSO), North Atlantic Oscillation (NAO), Indian Ocean dipole (IOD), Pacific decadal oscillation (PDO), Pacific–North American teleconnection pattern (PNA), Arctic Oscillation (AO), and Antarctic Oscillation (AAO), all based on reanalysis datasets, were analyzed for the 40-yr period 1980–2019. A strong linkage was found between TC activity and the AMM, IOD, and ENSO over the NIO. In addition, black carbon, organic carbon, sea salt, and sulfate aerosols have a significant impact on the cyclone frequency. Among these factors, black carbon, organic carbon, sea salt, and AMM account for the most variance of TCs, and among the other climate modes, IOD contributes more than ENSO. This is the first attempt to have identified this ranked set of aerosols and climate indices according to their relative ability to impact NIO TCs. Possible linkages between the thermodynamic and dynamic effects of aerosols on the Indian monsoon environment and its modifications to the large-scale environmental parameters relevant to TC development, namely, sea surface temperature, vertical wind shear, relative vorticity, and relative humidity during different phases of the climate modes are discussed.Significance StatementAerosols and climate modes have enormous impact on tropical cyclones (TCs). In this study, we evaluated the impact of aerosols and climate modes that modulate frequency of TCs over the north Indian Ocean. To assess the impact, a statistical generalized additive model based on Poisson regression was developed. A strong linkage was found between TC activity and Atlantic meridional mode, Indian Ocean dipole, and El Niño–Southern Oscillation, whereas other climate modes have no statistical significance. In addition, black carbon, organic carbon, sea salt, and SO4 aerosols have a strong linkage to cyclone frequency. The study postulates that most positive phases of these climate modes are associated with more TCs, while the negative phases are associated with fewer.