bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation and Analysis of Eye Discomfort Caused by Video Display Terminal Use Among Medical Students Studying at High-Altitude Regions
Authors: Liu Bingjie , Jiang Shanshan , Li Zuyou , Wang Yao , Zhou Daijiao , Chen Zhen 
Published: May 2022

ObjectiveTo investigate the use of video display terminal (VDT) in high-altitude regions by medical students and the resulted risk factors of eye discomfort.MethodsA cross-sectional study was conducted in 686 medical students randomly selected from high-altitude regions, Kunming, Yunnan Province. The prevalence of video display terminal syndrome (VDTs) and related risk factors in medical students were analyzed by instructing students to fill in the eye discomfort symptom questionnaire [Ocular Surface Disease Index (OSDI) scale].ResultsThere were 686 participants in this study, including 213 males (31.0%) and 473 females (69.0%). The results of questionnaire survey showed that 184 patients (26.8%) didn't have eye discomfort symptoms and 502 patients (73.2%) had eye discomfort symptoms. The comparison of demographic and ocular characteristics of eye discomfort symptoms group and no eye discomfort symptoms group showed that medical students in the group with ocular discomfort symptoms had longer total duration of video terminal use, longer duration of each VDT use, higher total scores of ocular discomfort symptom scores, and a higher percentage of the ocular discomfort severity group, all with statistically significant differences. There was no significant difference in the remaining parameters between the two groups of participants. The results of multivariate logistic regression model analysis showed that the relationship between total sleep time, total duration of VDT use and eye discomfort symptom score was statistically significant (P &lt; 0.05). Besides, ordinal logistic regression was applied further to investigate related factors of the severity of eye discomfort. The model demonstrated that total sleep duration and total VDT using duration were significantly associated with the severity of eye discomfort symptom (P &lt; 0.05).The severity of eye discomfort symptom was significantly negatively related to the increased total sleep duration and it was significantly positively related to the increased VDT use duration.ConclusionThe prevalence of VDTs is high in medical students at high-altitude regions. The longer total duration of daily use of VDT and shorter sleep duration are risk factors associated with VDTs. The severity of eye discomfort symptom was significantly negatively related to the increased total sleep duration and it was significantly positively related to the increased total VDT using duration.
Difference between “Lung Age” and Real Age as a Novel Predictor of Postoperative Complications, Long-Term Survival for Patients with Esophageal Cancer after Minimally Invasive Esophagectomy
Authors: Hong Zhi-Nuan , Weng Kai , Chen Zhen , Peng Kaiming , Kang Mingqiang 
Published: May 2022

BackgroundThis study aimed to investigate whether the difference between “lung age” and real age (L–R) could be useful for the prediction of postoperative complications and long-term survival in patients with esophageal cancer followed by minimally invasive esophagectomy (MIE).MethodsThis retrospective cohort study included 625 consecutive patients who had undergone MIE. “Lung age” was determined by the calculation method proposed by the Japanese Respiratory Society. According to L–R, patients were classified into three groups: group A: L–R ≦ 0 (n = 104), group B: 15 &gt; L–R &gt; 0 (n = 199), group C: L–R ≥ 15 (n = 322). Clinicopathological factors, postoperative complications evaluated by comprehensive complications index (CCI), and overall survival were compared between the groups. A CCI value &gt;30 indicated a severe postoperative complication.ResultsMale, smoking status, smoking index, chronic obstructive pulmonary disease, American Society of Anesthesiologists status, lung age, and forced expiratory volume in 1 s were associated with group classification. CCI values, postoperative hospital stays, and hospital costs were significantly different among groups. Multivariate analysis indicated that L–R, coronary heart disease, and 3-field lymphadenectomy were significant factors for predicting CCI value &gt;30. Regarding the prediction of CCI value &gt;30, area under the curve value was 0.61(95%: 0.56–0.67), 0.46 (95% CI, 0.40–0.54), and 0.46 (95% CI, 0.40–0.54) for L–R, Fev1, and Fev1%, respectively. Regarding overall survival, there was a significant difference between group A and group B + C (log-rank test: p = 0.03).ConclusionsEsophageal cancer patients with impaired pulmonary function had a higher risk of severe postoperative complications and poorer prognosis than those with normal pulmonary function. The difference between “lung age” and “real age” seems to be a novel and potential predictor of severe postoperative complications and long-term survival.
GATA3 Predicts the Tumor Microenvironment Phenotypes and Molecular Subtypes for Bladder Carcinoma
Authors: Zhang Qixin , Qi Tiezheng , Long Yu , Li Xiaowen , Yao Yiyan , Wu Qi , Zou Anrong , Qthmane Belaydi , Liu Peihua 
Published: May 2022

AimsGATA3 is a key player in antitumor immunology, and continuous studies show that it might be a key biomarker for bladder cancer (BLCA). Thus, we lucubrate the immunological role of GATA3 in BLCA.Main MethodsWe initially used pan-cancer analysis to analyze the expression pattern and immunological function of GATA3 with data gathered from the TCGA (The Cancer Genome Atlas). Then, in the BLCA tumor microenvironment (TME), we comprehensively associated GATA3 with immunomodulators, cancer immune cycles, tumor-infiltrating immune cells (TIICs), immune checkpoints, and T-cell inflamed scores(TIS). The role of GATA3 in predicting BLCA molecular subtypes and responsiveness to various treatment regimens was also investigated. We confirmed our findings in an external cohort and the Xiangya-Pingkuang cohort to guarantee the correctness of our study.Key FindingsGATA3 was preferentially expressed in the TME of numerous malignancies, including BLCA. High GATA3 expression was adversely connected with immunological aspects such as immunomodulators, cancer immune cycles, TIICs, immune checkpoints, and TIS in the BLCA TME. In addition, high GATA3 was more likely to be a luminal subtype, which meant it was less susceptible to cancer immunotherapy and neoadjuvant chemotherapy but more sensitive to targeted treatments.SignificanceGATA3 may aid in the precision treatment for BLCA because it can accurately predict the clinical outcomes and the TME characteristics of BLCA.
Effect Observation of Electro-Acupuncture Anesthesia Combined with General Anesthesia in Elderly Patients Undergoing Gastrointestinal Tumor Resection
Authors: Xu Jiping , Li Peng , Zheng Liyan , Chen Qiong 
Published: May 2022

ObjectiveTo investigate the anesthetic effect of electro-acupuncture (EA) anesthesia combined with general anesthesia in elderly patients undergoing gastrointestinal tumor resection, and to analyze the effects of EA anesthesia on inflammatory factors, stress state and T lymphocyte subsets in elderly patients.MethodsTotal of 118 elderly patients who underwent gastrointestinal tumor resection in our hospital from June 2018 to March 2021 were selected and divided into the control group (59 cases) and the observation group (59 cases) according to the random number method. General anesthesia was adopted in the control group and EA anesthesia combined with general anesthesia was adopted in the observation group. The anesthesia effect, stress state, levels of inflammatory factors, T-lymphocyte subsets and adverse reactions were compared.ResultsThe VAS score, agitation score and respiratory normalization time in the observation group were lower than those in the control group (p &lt; 0.05). After surgery, the levels of serum Cor, ET, NE and DA in the observation group were lower than those in the control group (p &lt; 0.05). At 24 h after surgery, the levels of serum TNF-α, IL-6 and IL-1β in the observation group were lower than those in the control group (p &lt; 0.05). At 24 h after surgery, the levels of CD3+, CD4+, and CD4+//CD8+ in the two groups were lower than those before surgery, and the levels of CD3+, CD4+, and CD4+//CD8+ in the observation group were higher than those in the control group (p &lt; 0.05). During the hospitalization, the total incidence rate of adverse reactions after anesthesia in the observation group was lower than that in the control group (p &lt; 0.05).ConclusionEA anesthesia combined with general anesthesia has good anesthesia effect when used for gastrointestinal tumor resection in the elderly. It can stabilize the internal environment of patients, alleviate postoperative stress response and inflammatory response, and regulate the body immune function. Moreover, it has high safety and can significantly reduce the occurrence of postoperative adverse reactions.
Elevada prevalência de consumo inadequado de psicoestimulantes por universitários da área da saúde / High prevalence of inadequate psychostimulants use among students from health area
Authors: Pereira Augusto Eleutério , Mata Bianca Souza da , Filho Carlos Ferreira , Fernandes Fernanda Stheffani Abreu , Yamagata Juliana Thamye , Medeiros Linda Maria Avelar , Lebourg Lorena Rocha , Sant’ana Raphael Ghedin Servidei , Dias Anna Marcella Neves , Mende Nathália Barbosa do Espírito Santo , Franco Danielle Cristina Zimmermann 
Published: May 2022

Os psicoestimulantes são substâncias capazes de aumentar o estado de alerta, desempenho intelectual e concentração dos usuários. O uso dessas substâncias têm crescido exponencialmente por estudantes na busca de um melhor desempenho acadêmico e seu uso irracional pode causar efeitos indesejáveis graves. O objetivo deste estudo foi conhecer a prevalência e delinear o perfil do estudante que utiliza psicoestimulantes como automedicação, além de investigar fatores associados a esse comportamento dentre universitários da área da saúde. Trata-se de um estudo observacional, de caráter transversal composto por 378 universitários da área da saúde que responderam a um questionário sobre o uso de substâncias psicoestimulantes. Os resultados demonstraram que a maior parte da amostra fez uso de alguma substância psicoestimulante visando melhorar o desempenho acadêmico. Observou-se que há um predomínio de mulheres, com média de idade 24±4,5 anos e que a maioria dos universitários cursavam Medicina entre o quinto e o oitavo período em turno integral. Residir com os familiares foi encontrado como fator de proteção para esse comportamento. A cafeína foi a principal responsável pela alta prevalência no consumo de psicoestimulantes encontrada nesta amostra. Diante do achado, sugere-se a importância da participação das instituições de ensino superior na conscientização sobre o uso irracional dessa classe de substâncias, visando assim, diminuir o consumo e, consequentemente, o risco do surgimento de efeitos indesejáveis relacionados ao uso de psicoestimulantes.
Long-term follow-up of a case of multicystic ameloblastoma treated with curettage: case report / Acompanhamento a longo prazo de um caso de ameloblastoma multi-cístico tratado com curetagem: relato de caso
Authors: Oliveira Maiolino Thomaz Fonseca , Almeida Vinícius Lima de , Rodrigues Cristóvão Marcondes de Castro , Paulo Luiz Fernando Barbosa de , Barbosa Darceny Zanetta 
Published: May 2022

The conventional or multicystic solid ameloblastoma is the most common type with the majority of cases affecting the posterior region of the mandible and occurring between the third and fourth decades of life. The present study aims to report a case of multicystic ameloblastoma in which treatment by means of curettage was chosen and no evidence of recurrence was noted over 7 years of follow-up. Although the literature indicates aggressive surgical therapy as the best form of treatment for multicystic ameloblastoma, factors such as the clinical, radiographic and histopathological aspects of the lesion, patient age, postoperative morbidity, possibilities for aesthetic and functional changes must be evaluated together during treatment planning. In some cases, as in the report presented, conservative therapies such as aggressive curettage of the lesion can be effective in the long term, with no recurrence of the lesion and providing quality of life to the patient.
Características de carcaça e rendimento de cortes comerciais de novilhos das raças Crioula Lageana e Nelore sob condições do planalto catarinense / Carcass traits and yelding comercial cuts of Crioula Lageana and Nellore steers raised under Santa Catarina highland conditions
Authors: Quadros Sergio Augusto Ferreira de , Martins Edison , Veiga Thiago Filipe 
Published: May 2022

Neste estudo compararam-se as características quali- quantitativas de carcaça das raças Crioula Lageana e Nelore sob condições ambientais do planalto sul catarinense. Foram avaliados 24 machos inteiros de 18 a 24 meses de idade, sendo 12 da raça Crioula Lageana e 12 Nelore. Os animais foram mantidos em campo nativo “palha fina” durante 90 dias e receberam sal proteinado. No inverno, foram introduzidos em pastagem de centeio, aveia e azevém, por 74 dias até atingirem o peso de abate (505,8 kg ± 58,78 kg). Com relação às características estudadas, a análise multivariada e a ANOVA indicaram que a raça Crioula Lageana foi superior à Nelore em escore de marmoreio (2,66 vs. 1,41); área de olho de lombo (65,33 vs. 58,58 cm² ; gordura subcutânea (7,25 vs. 5,70 mm). Entretanto, o Nelore obteve maior rendimento de quarto traseiro (167,36 vs. 154,75 kg); quarto dianteiro (107,44 vs. 92,43 kg) e traseiro serrote (139,1 vs. 124,51 kg). Para os cortes comerciais a análise indicou que a raça Crioula Lageana obteve maior peso médio para: entrecôte (4,063 vs. 3,510 kg). A raça Nelore obteve maiores rendimentos nas peças de filé mignon (2,188 vs. 2,152 kg); coxão mole (9,829 vs. 8,222 kg); lagarto (2,578 vs. 2,144 kg) e picanha (1,303 vs. 1,06 kg). Quanto às correlações estudadas verificou-se correlação positiva entre AOL e Lombo (0,555); AOL e filé mignon (0,553); AOL e coxão mole (0,583); traseiro serrote e filé mignon (0,812); traseiro serrote e lagarto (0,491); traseiro serrote e entrecôte (0,604); traseiro serrote e picanha (0,755). A raça Crioula Lageana apresentou características qualitativas superiores à Nelore, no entanto, apresentou menor rendimento de carcaça (50,14 vs. 52,97 %) e menores pesos para os cortes comercias estudados.
La educación indígena en tiempos del COVID-19 en Xochistlahuaca, Gro. El caso de la escuela El Porvenir / Indigenous education in times of COVID-19 in Xochistlahuaca, Gro. The case of El Porvenir school
Authors: Nuñez José Manuel Juárez , Salinas Sonia Comboni 
Published: May 2022

La educación en tiempos de COVID 19, en el sector indígena de Guerrero ha experimentado diferentes estrategias para superar las barreras para el aprendizaje surgidas durante el surgimiento de la pandemia global provocada por el virus SARS-COV2, conocido como COVID 19, por el año en que se manifestó en la ciudad de Wuhan China, sobre todo a finales del año 2019. La pandemia originada en China provocada por una nueva cepa de coronavirus se expandió a otros países de Asia, Europa y América, afectando a México, oficialmente desde el 28 de marzo del 2020 (“https://www.bupasalud.com.mx/salud/coronavirus, consultados el 12 de octubre 2020).La estrategia estatal para prevenir un contagio masivo fue el enclaustramiento, vehiculado por el lema “Quédate en Casa” y guarda “Susana distancia”. El suspender actividades no esenciales para la vida de la sociedad implicó el cierre de las escuelas e impulsar la educación a distancia y la virtual. Esto significó una barrera para el aprendizaje adicional a las ya consideradas como permanentes y tradicionales. Los y las estudiantes recibían clases por Televisión, celular, internet e incluso mediante visitas de los maestros y maestras a los hogares de los estudiantes. Los docentes de la escuela El Porvenir de educación indígena con su proyecto de “Educación para la Vida” acudían a los domicilios de los alumnos para impartir clases y dejarles sus tareas, distribuyendo los programas con la ayuda de los padres de familia y de las autoridades educativas y municipales. Es un ejemplo importante de la dedicación y responsabilidad de los maestros y maestras con la formación de la niñez y la juventud en una educación para la vida en una comunidad educativa y de aprendizaje en la que todos colaboran para preparar un futuro mejor para sus hijos mediante una educación pertinente y significativa, tratando de superar las barreras para el aprendizaje. El nivel del aprendizaje, sin duda alguna, disminuyó considerablemente, según declaraciones de los padres de familia.
Physiological and blood evaluation of horses submitted to exercises in different seasons of the year / Avaliação fisiológica e sanguínea de equinos submetidos a exercícios em diferentes estações do ano
Authors: Machado Fábio Souza , Gandra Jefferson Rodrigues , Pedrini Cibeli de Almeida , Gandra Erika Rosendo de Sena , Mendes Paulo Vinícius da Costa 
Published: May 2022

Devido à crescente variedade nos esportes equestres e às raças de cavalos, tornou-se importante a avaliação da fisiologia do exercício animal. Os equinos são submetidos a treinamentos em condições de campo para o estabelecimento de condicionamento físico e até mesmo de programas nutricionais dos animais. A preocupação com o estresse térmico é uma realidade, principalmente para cavalos atletas, cujo o valor agregado no animal é maior. Este trabalho teve por objetivo avaliar parâmetros fisiológicos e sanguíneos de animais submetidos a exercícios em diferentes estações do ano. Foram utilizados 10 animais Quarto de Milha de diferentes idades e sexos. O experimento teve duração de seis dias, sendo três dias no inverno e três dias no verão, formando um fatorial 3x2 (três períodos e duas estações). Foram avaliados temperatura de pele, temperatura retal, emissividade de calor nos olhos e ceco, frequência respiratória e cardíaca, e parâmetros sanguíneos (glicose, colesterol total, triglicerídeos, proteína total, albumina, uréia, contagem de hemácias, hemoglobina e leucócitos), antes do início do exercício e após o término dos mesmos. Houve diferença estatística para estação do ano para as variáveis triglicerídeos, sendo maior no inverno, proteína e albumina, contagem de hemácias e leucócitos, sendo maiores no verão. A variável glicose apresentou interação entre tempo de coleta e estação. A frequência cardíaca, temperaturas da pele e retal diferiram em relação as estações, apresentando maior aumento no verão. Houve diferença estatística quanto a emissividade de calor nos olhos, sendo maior no verão. A emissividade do ceco apresentou interação entre estação do ano e período de coleta. A temperatura ambiente e a estação do ano interferem nas respostas fisiológicas de dissipação de calor dos equinos.
Diseño de grafos tipo árbol de expansión a partir de matrices de transporte
Authors: Martínez-Flores Sergio Fabricio , Rojas-Alvarado Alex Heriberto , Tipanquiza-Rubio Jissela Johana 
Published: May 2022

Se tiene por objetivo realizar un diseño de grafos tipo árbol de expansión a partir de matrices de transporte. Se trabajó con una metodología de proyecto factible, en consideración la teoría de grafos el cual permite establecer la ruta óptima para el transporte. Los datos de la matriz asignada para la resolución del caso práctico, muestra la información de los tiempos de viaje entre zonas de la ciudad de Durán, mismas que han servido de base para el diseño de los árboles de expansión de las zonas uno y dos. Se dividió el área de estudio en catorce zonas, con sus respectivos centroides de mayor generación y atracción de viajes de la población y de esta forma se desarrolló una red una red de transporte que une a todos los nodos de la ciudad de Durán.
Efektivitas Perineal Massage Dalam Menurunkan Tingkat Laserasi Perineum Pada Ibu Postpartum Primipara
Authors: Subroto Elvira Trista , Sangkala Fitriani 
Published: May 2022

Pendahuluan: laserasi perineum adalah ruptur pada jalan lahir atau robeknya jaringan pada area perineum yaitu pada area antara otot vagina dan anus, yang terjadi akibat persalinan terlalu cepat dan kepala bayi lahir besar.
Tujuan: Mengidentifikasi penurunan tingkat laserasi perineum pada ibu postpartum primipara.
Metode: desain dari pendekatan metodologi penelitian ini adalah literature review agar dapat menentukan berbagai bukti kuantitatif dan kualitatif menggunakan database elektronik yaitu: Pubmed, Google Scholar dan Garuda, lalu dilakukan pembatasan dengan berdasarkan kriteri inkluis sehingga menghasilkan 876 responden. Analisis menggunakan peta data yang diekstrasi pada tabel hasil pencarian artikel termasuk penulis, tahun publikasi,Negara, tujuan, sampel, desain penelitian, jenis penelitian, lama intervensi, hasil dan kesimpulan penelitian.
Hasil: menunjukkan bahwa tindakan ini efektif dalam menurunkan tingkat derajat laserasi dan mempertahankan keutuhan laserasi dengan pelaksaan yang sesuai dengan waktu yang dianjurkan.
Kesimpulan: bahwa terapi ini aman dan sangat disarakan untuk masuk dalam list kelas ibu hamil serta di sarankan untuk melakukan pendidikan kesehatan pada para ibu agar menambah pengetahuan tentang cara mencegah terjadi laserasi perineum
Korelasi Gaya Hidup dan Stres Pada Penderita Hiperkolesterolemia
Authors: Lainsamputty Ferdy , Gerungan Nova 
Published: May 2022

Latar belakang: Dislipidemia menyebabkan mortalitas yang tinggi di seluruh dunia, sekitar 4 juta kematian per tahunnya. Gaya hidup penderita dengan kadar kolesterol tinggi cenderung buruk yang berpotensi memicu penyakit kardiovaskuler. Stres kronis pada populasi ini juga diduga berhubungan erat dengan gaya hidup buruk.
Tujuan: Menginvestigasi hubungan antara gaya hidup dan stres pada pasien hiperkolesterolemia.
Metode: Penelitian ini berdesain deskriptif korelasi dan cross-sectional dengan 53 responden. Kuesioner yang digunakan yaitu Health Promoting Lifestyle Profile (HPLP II) dan Perceived Stress Scale (PSS).
Hasil: Tidak terdapat hubungan yang signifikan antara gaya hidup dan stres secara keseluruhan. Domain manajemen stres memiliki hubungan yang signifikan dengan stres.
Kesimpulan: Pasien hiperkolesterolemia yang memiliki pengontrolan kondisi psikologis yang baik, memiliki tingkat stres yang lebih rendah.
Kyropoulos growth of a 300 g SrB4O7 single crystal using a twin-type stirring blade
Authors: Tanaka Yasunori , Murai Ryota , Takahashi Yoshinori , Empizo Melvin John F. , Usami Shigeyoshi , Maruyama Mihoko , Imanishi Masayuki , Mori Yusuke , Yoshimura Masashi 
Published: May 2022

Abstract
We report the successful Kyropoulos growth of a large strontium tetraborate (SrB4O7, SBO) single crystal that weighs more than 300 g. In order to grow the large and transparent crystal, a new twin-type stirring blade was used along with a 150 mm diameter crucible. The use of the stirring blade results in the production of the world’s largest SBO crystal with dimensions of 100 mm (a) ×30 mm (b) ×32 mm (c), a weight of 328.2 g, and wide transparency down to 130 nm. These results will then lead to the development of large SBO crystals as optical window materials for high-power DUV laser processing systems.