bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Internal Fluid on the Dynamic Behaviors of Double Cylindrical Shells Subjected to Underwater Explosion
Authors: Huang Shizhang , Tong Xiandong , Chen Yong , Li Zengguang 
Published: January 2022

Abstract
Fluid-filled double cylindrical shells were widely used in the marine engineering field and their blast resistance was considerably concerned. In this paper, the dynamic behaviors of fluid-filled double cylindrical shells subjected to underwater explosion were studied through a combination of experimental and numerical methods. First, a series of comparative underwater explosion tests were carried out on the scaled empty and fluid-filled double cylindrical shells. Then, more detailed numerical simulations were developed to give more results, and the model was verified by comparing with the data gathered from tests. Based on the experimental and numerical results, the effects of internal fluid on the shock wave propagation process, deformation modes, dynamic response, and energy characteristics of structures were analyzed. It is shown that the internal fluid is helpful to resist the structural deformation of outer shell and significantly decreased the axial strains of inner shell. Meanwhile, the dynamic response of the inner shell of fluid-filled shells was more violent. Besides, the internal and kinetic energy of outer shell decreased markedly. Above results would provide a reference for the protection of fluid-filled structures.
Coupled Flexural–Torsional Forced Vibration Analysis of a Piezoelectrically Actuated Double-Cantilever Structure
Authors: Zargarani Anahita , O’Donnell John , Mahmoodi S. Nima 
Published: January 2022

Abstract
In this paper, the forced coupled flexural–torsional vibration of a piezoelectrically actuated double-cantilever structure is investigated. The double-cantilever structure is composed of two uniform and identical Euler–Bernoulli cantilever beams connected by a rigid tip connection at their free ends. There is also a piezoelectric layer attached on the top surface of each cantilever beam. The characteristic equation for the coupled flexural–torsional vibrations of the structure is derived and solved to determine the natural frequencies. The time response to the forced vibrations of the structure is studied using the Galerkin approximation method. The effects of dimensional parameters, including the length of the cantilever beams and the length of the tip connection, and the piezoelectric input voltage on the coupled flexural–torsional natural frequencies and amplitude of vibrations of the structure are investigated analytically and experimentally. The results show that the coupled flexural–torsional fundamental frequency of the piezoelectrically actuated double-cantilever structure decreases as either the length of the cantilever beams or the tip connection is increased. Moreover, the amplitude of the coupled flexural–torsional vibrations of the structure is proportional to the piezoelectric input voltage; however, the slope of the curves depends on dimensional parameters. For a given voltage, the effect of either of the aforementioned dimensional parameters on the amplitude of vibrations depends on the other dimensional parameter such that there is a turning point in all the curves, whose location depends on the configuration of the structure.
Reproducibility of deep learning based scleral spur localisation and anterior chamber angle measurements from anterior segment optical coherence tomography images
Authors: Liu Peng , Higashita Risa , Guo Philip Yawen , Okamoto Keiichiro , Li Fei , Nguyen Anwell , Sakata Rei , Duan Lixin , Aihara Makoto , Lin Shan , Zhang Xiulan , Leung Christopher Kai-Shun , Liu Jiang 
Published: January 2022

AimsTo apply a deep learning model for automatic localisation of the scleral spur (SS) in anterior segment optical coherence tomography (AS-OCT) images and compare the reproducibility of anterior chamber angle (ACA) width between deep learning located SS (DLLSS) and manually plotted SS (MPSS).MethodsIn this multicentre, cross-sectional study, a test dataset comprising 5166 AS-OCT images from 287 eyes (116 healthy eyes with open angles and 171 eyes with primary angle-closure disease (PACD)) of 287 subjects were recruited from four ophthalmology clinics. Each eye was imaged twice by a swept-source AS-OCT (CASIA2, Tomey, Nagoya, Japan) in the same visit and one eye of each patient was randomly selected for measurements of ACA. The agreement between DLLSS and MPSS was assessed using the Euclidean distance (ED). The angle opening distance (AOD) of 750 µm (AOD750) and trabecular-iris space area (TISA) of 750 µm (TISA750) were calculated using the CASIA2 embedded software. The repeatability of ACA width was measured.ResultsThe mean age was 60.8±12.3 years (range: 30–85 years) for the normal group and 63.4±10.6 years (range: 40–91 years) for the PACD group. The mean difference in ED for SS localisation between DLLSS and MPSS was 66.50±20.54 µm and 84.78±28.33 µm for the normal group and the PACD group, respectively. The span of 95% limits of agreement between DLLSS and MPSS was 0.064 mm for AOD750 and 0.034 mm2for TISA750. The respective repeatability coefficients of AOD750 and TISA750 were 0.049 mm and 0.026 mm2for DLLSS, and 0.058 mm and 0.030 mm2for MPSS.ConclusionDLLSS achieved comparable repeatability compared with MPSS for measurement of ACA.
Assessing the size spectra of marine fish communities with hydroacoustics: examining the challenges of abundant schools, diverse assemblages, and variable orientations
Authors: Bolser Derek G. , Egerton Jack P. , Souza Philip M. , Boswell Kevin M. , Erisman Brad E. 
Published: January 2022

Assessing marine fish community size spectra with hydroacoustics is challenging, as communities are diverse, schooling and swim-bladder-less fishes are common, and fish orientation is variable. We developed an approach to examine these challenges and applied it to data from 51 optic–acoustic surveys of fishes at petroleum platforms throughout the US Gulf of Mexico. When in situ target strength (TS; dB re 1 m2) distributions were used to calculate the density (and subsequently abundance) of schooling fishes, fish lengths and size spectra slopes were significantly smaller than in simulated communities and fish community censuses at platforms (i.e., reference datasets). However, acoustic slopes were comparable to reference slopes when simulated TS values (based on species composition) were used to calculate schooling fish abundance. These findings held regardless of whether specific or general models were used to convert TS to length. Fish orientation was not a useful predictor of TS or slope, but may explain why in situ TS measurements from small groups of fishes around schools were unsuitable for abundance calculations. By examining the challenges associated with assessing size spectra with acoustics, this study aids progress towards using acoustic size spectra metrics for ecological inferences.
Root adaptations of black spruce growing in water-saturated soil
Authors: Krause Cornelia , Lemay Audrey 
Published: January 2022

Black spruce (Picea mariana (Mill.) BSP) is the main tree species growing within peatlands. The difficult growing conditions within peatlands are associated with low individual wood productivity, and only tree species tolerant to high ground water level can survive. We examine the effect of water-saturated soil on the growth potential of black spruce trees and specific adaptation of the root system. Experimental mesocosms were constructed with two drainage regimes (saturated and well-drained soil conditions). We measured biomass, height, and diameter at stem base of 55 black spruce saplings and noted the location of each horizontal root. Black spruce exhibited a very shallow root system located above saturated commercial peat 19 years after the experiment was initiated. Most roots were adventitious in the water-saturated mesocosms. Overall aerial and root biomass accumulation of the black spruce trees growing under saturated soil conditions was significantly lower than that of the well-drained mesocosms. Interestingly, root–shoot ratios were similar across the two drainage regimes. Soil conditions induced adaptation of the root system in black spruce trees, and physiological stress affected the entire individual with lower biomass productivity in all components (stem, branches, root system). However, biomass distribution remained similar to that of trees growing in well-drained mesocosms.
Dynamical particles in spatially flat FLRW space-times
Authors: Cotăescu Ion I. 
Published: January 2022

AbstractMetrics of dynamical point particles embedded in spatially flat FLRW space-times are derived as isotropic solutions of the Einstein equations with the energy–momentum tensor of a perfect fluid. These particles are produced by central singularities of the fluid density but without changing the pressure of the asymptotic FLRW space-times. It is shown that each particle gets a dynamical photon sphere before a critical instant when two dynamical apparent horizons arise just on the photon sphere evolving then as C-curves. The angular radius of the shadow associated to the photon sphere is derived and compared with the known results.
(Invited) An Electrochemical Perspective on Electrophysiological Measurements
Authors: Yeh Malcolm H. , Leddy Johna 
Published: January 2022

Electrophysiological measurement such as EEG and peripheral nerve conduction studies are commonly used in neurology research and medical diagnoses. Bioelectrochemical structures and reactions at the molecular to micrometer scale propagate charge through space. Electrophysiological measurements made across distances on the scale of centimeters map collective effects of many charge propagation events. In peripheral nerves, charge propagates along nerves in the limbs at ~50 m/s. Voltages measured from the surface of the skin are in the range of 6 to 8 µV for peripheral nerves and as high as 40-60 µV in EEG studies. Charge propagation events that generate measured electrophysiological signals can be viewed with the same electrostatic fundamentals that describe how potentials are established in electrochemical systems.
Polarization of a synaptic membrane generates a flux of positive charge and then a charge balancing flux of negative charge as the membrane depolarizes. The flux separates charge that generates a dipole. The dipole propagates down a peripheral nerve as the membrane separates charge sequentially. A sketch of the dipole is based in electrostatics.
From an electrostatic perspective, the separation and magnitude of the charges establishes an electrical potential Φ(x,y,z). Consider a single dipole at an instant in time. Evaluation of charge separation yields a map of potential in space as shown in the Figure. The gradient in the electrical potential establishes the electric field. Migration is driven by potential gradients such that the electric field may play a role in dipole propagation.
The Figure is an instantaneous snapshot of potential associated with a dipole in space. In electrophysiological measurements, multiple dipoles events yield the measured voltages as nerve impulses that propagate in time along a peripheral nerve tract. A sketch of the correlations between electrophysiological measurements and electrochemical fundamentals is presented.
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Figure 1
Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers
Authors: George Suzanne , von Mehren Margaret , Fletcher Jonathan A. , Sun Jichao , Zhang Sen , Pritchard Justin R. , Hodgson John Graeme , Kerstein David , Rivera Victor M. , Haluska Frank G. , Heinrich Michael C. 
Published: January 2022

Abstract

Purpose:
The purpose of this study is to evaluate ponatinib for advanced gastrointestinal stromal tumors (GIST).

Patients and Methods:
This single-arm phase II trial enrolled patients with metastatic and/or unresectable GIST with failure of prior tyrosine kinase inhibitor (TKI) treatment into two cohorts based on presence or absence of KIT exon 11 (ex11) primary mutations. Patients initially received ponatinib 45 mg once daily. Following a temporary clinical hold in October 2013, dose reductions were implemented to reduce risk of arterial occlusive events (AOE). Primary endpoint was 16-week clinical benefit rate (CBR) in KIT ex11–positive cohort. KIT mutations in circulating tumor DNA (ctDNA) were assessed.

Results:
Forty-five patients enrolled (30 KIT ex11–positive and 15 KIT ex11–negative); median follow-up was 14.7 and 13.6 months, respectively, as of August 1, 2016. Sixteen-week CBR was 36% (KIT ex11–positive; primary endpoint) and 20% (KIT ex11–negative). ctDNA analyses (n = 37) demonstrated strong concordance of primary KIT mutations between plasma and tumor. At least two secondary mutations were detected in 35% of patients overall and 54% of KIT ex11–positive patients. Changes from baseline in mutated ctDNA levels were consistent with clinical activity. Ponatinib was ineffective in patients with KIT exon 9 primary mutations. Resistance was associated with emergence of V654A. AOEs and venous thromboembolic events occurred in three and two patients, respectively. Six patients died; two deaths (pneumonia and pulmonary embolism) were considered possibly ponatinib-related.

Conclusions:
Ponatinib demonstrated activity in advanced GIST, particularly in KIT ex11–positive disease. ctDNA analysis confirmed heterogeneous resistance mutations in TKI-pretreated advanced GIST. Safety was consistent with previous studies.
Expanding Therapeutic Opportunities for Extrapulmonary Neuroendocrine Carcinoma
Authors: Frizziero Melissa , Kilgour Elaine , Simpson Kathryn L. , Rothwell Dominic G. , Moore David A. , Frese Kristopher K. , Galvin Melanie , Lamarca Angela , Hubner Richard A. , Valle Juan W. , McNamara Mairéad G. , Dive Caroline 
Published: January 2022

Abstract
Poorly differentiated neuroendocrine carcinomas (PD-NEC) are rare cancers garnering interest as they become more commonly encountered in the clinic. This is due to improved diagnostic methods and the increasingly observed phenomenon of “NE lineage plasticity,” whereby nonneuroendocrine (non-NE) epithelial cancers transition to aggressive NE phenotypes after targeted treatment. Effective treatment options for patients with PD-NEC are challenging for several reasons. This includes a lack of targetable, recurrent molecular drivers, a paucity of patient-relevant preclinical models to study biology and test novel therapeutics, and the absence of validated biomarkers to guide clinical management. Although advances have been made pertaining to molecular subtyping of small cell lung cancer (SCLC), a PD-NEC of lung origin, extrapulmonary (EP)-PD-NECs remain understudied. This review will address emerging SCLC-like, same-organ non-NE cancer-like and tumor-type–agnostic biological vulnerabilities of EP-PD-NECs, with the potential for therapeutic exploitation. The hypotheses surrounding the origin of these cancers and how “NE lineage plasticity” can be leveraged for therapeutic purposes are discussed. SCLC is herein proposed as a paradigm for supporting progress toward precision medicine in EP-PD-NECs. The aim of this review is to provide a thorough portrait of the current knowledge of EP-PD-NEC biology, with a view to informing new avenues for research and future therapeutic opportunities in these cancers of unmet need.
Supersaturation Variability from Scalar Mixing: Evaluation of a New Subgrid-Scale Model Using Direct Numerical Simulations of Turbulent Rayleigh–Bénard Convection
Authors: Chandrakar Kamal Kant , Morrison Hugh , Grabowski Wojciech W. , Bryan George H. , Shaw Raymond A. 
Published: January 2022

Abstract
Supersaturation fluctuations in the atmosphere are critical for cloud processes. A nonlinear dependence on two scalars—water vapor and temperature—leads to different behavior than single scalars in turbulent convection. For modeling such multiscalar processes at subgrid scales (SGS) in large-eddy simulations (LES) or convection-permitting models, a new SGS scheme is implemented in CM1 that solves equations for SGS water vapor and temperature fluctuations and their covariance. The SGS model is evaluated using benchmark direct-numerical simulations (DNS) of turbulent Rayleigh–Bénard convection with water vapor as in the Michigan Tech Pi Cloud Chamber. This idealized setup allows thorough evaluation of the SGS model without complications from other atmospheric processes. DNS results compare favorably with measurements from the chamber. Results from LES using the new SGS model compare well with DNS, including profiles of water vapor and temperature variances, their covariance, and supersaturation variance. SGS supersaturation fluctuations scale appropriately with changes to the LES grid spacing, with the magnitude of SGS fluctuations decreasing relative to those at the resolved scale as the grid spacing is decreased. Sensitivities of covariance and supersaturation statistics to changes in water vapor flux relative to thermal flux are also investigated by modifying the sidewall conditions. Relative changes in water vapor flux substantially decrease the covariance and increase supersaturation fluctuations even away from boundaries.
Finding Storm Track Activity Metrics That Are Highly Correlated with Weather Impacts. Part II: Estimating Precipitation Change Associated with Projected Storm Track Change over Europe
Authors: Chang Edmund Kar-Man , Yau Albert Man-Wai , Zhang Rui 
Published: January 2022

AbstractThe extratropical storm tracks cause much of the high-impact weather in the midlatitudes, and thus it is of interest to examine the weather impacts of projected storm track change. Here, a framework for quantifying storm track impact on precipitation over Europe developed in Part I for winter is extended to all four seasons and applied to estimate the precipitation impacts of CMIP5 and CMIP6 model projected storm track change under the high-emission scenarios. For autumn and winter, a significant portion of the projected decrease in precipitation over southern Europe and the Mediterranean Sea region can be related to a projected decrease in storm track activity over these regions. In winter, the projected increase in storm track activity near the British Isles accentuates the precipitation increase over that region. In summer, a projected storm track decrease over northern Europe is expected to give rise to a decrease in precipitation that expands the projected drying region poleward and reduces the impact of the projected high-latitude precipitation increase related to the increase in atmospheric moisture. CMIP6 models project stronger drying than CMIP5 models over central and northern Europe in summer and autumn. Part of this increased drying can be related to an enhanced decrease in storm track activity projected by CMIP6 models. Apart from multimodel mean projections, different model projected storm track change patterns can give rise to very different regional precipitation impacts, and account for the model spread in precipitation projection in many regions. What causes such model diversity should be further examined.
The Impact of the Direct Radiative Effect of Increased CO2 on the West African Monsoon
Authors: Mutton Harry , Chadwick Robin , Collins Matthew , Lambert F. Hugo , Geen Ruth , Todd Alexander , Taylor Christopher M. 
Published: January 2022

AbstractProjections of future West African monsoon (WAM) precipitation change in response to increasing greenhouse gases are uncertain, and an improved understanding of the drivers of WAM precipitation change is needed to help aid model development and better inform adaptation policies in the region. This paper addresses one of those drivers, the direct radiative effect of increased CO2(i.e., the impact of increased CO2in the absence of SST warming and changes in plant physiology). An atmosphere-only model is used to examine both the equilibrium response and the evolution of the change over the days following the instantaneous CO2increase. In response to the direct radiative effect, WAM precipitation increases due to a weakening of the shallow meridional circulation over North Africa, advecting less dry air into the convective column associated with the monsoon. Changes in the shallow circulation are associated with atmospheric and surface warming patterns over North Africa. A large-scale atmospheric warming pattern, whereby North Africa warms more than the monsoon region, leads to a northward shift in the Saharan heat low. In response to increased precipitation in the Sahel, local soil moisture feedbacks play a key role in determining the low-level circulation change and the location of the intertropical discontinuity. The large-scale warming patterns over North Africa result from differing levels of constraint applied by convective quasi-equilibrium. While this constraint acts strongly in the equatorial WAM region, preventing the region from warming in response to the direct radiative effect, North Africa is not strongly constrained and is therefore able to warm.
Change in Climate Sensitivity and Its Dependence on the Lapse-Rate Feedback in 4 × CO2 Climate Model Experiments
Authors: Eiselt Kai-Uwe , Graversen Rune Grand 
Published: January 2022

Abstract
Robust estimates of climate sensitivity are important for decision-making on mitigation of climate change. However, climate sensitivity and its governing processes are still subject to large uncertainty. Recently it has been established that climate sensitivity changes over time in numerical climate model experiments with abrupt quadrupling of the CO2 concentration. Here we conduct an analysis of such experiments from a range of climate models from phases 5 and 6 of the Coupled Model Intercomparison Project (CMIP). Climate feedbacks associated with clouds, lapse rate, Planck radiation, surface albedo, and water vapor and their changes over time are diagnosed based on a radiative kernel method. We find two clearly distinct model groups, one with weak and one with strong lapse-rate feedback change. The Arctic is the region showing the largest differences between these two model groups, with respect to both warming change and individual feedback changes. We retrace this change to the development over time of the Arctic sea ice, which impacts both the surface-albedo and lapse-rate feedbacks. Generally, models that warm quickly, both globally and in the Arctic, also quickly lose their Arctic sea ice and change their total global-mean climate feedback only little, and vice versa. However, it remains unclear if the Arctic changes are a cause or rather a by-product of the total global-mean feedback change. Finally, we find support for the results of previous studies finding that the relative warming in the tropical Indo-Pacific region may control the change of total climate feedback over time.