bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of Dignity Therapy narratives among people with severe mental illness and people with cancer
Authors: Grassi Luigi , Nanni Maria Giulia , Caruso Rosangela , Ounalli Heifa , Chochinov Harvey M. , Biancosino Bruno , Testoni Ines , Murri Martino Belvederi , Bertelli Tatiana , Palagini Laura , De Padova Silvia , Tiberto Elisa 
Published: February 2022

AbstractObjectiveTo examine Dignity Therapy (DT) narratives in patients with severe mental illness (SMI) and a control group of cancer patients.Methods12 patients with SMI (schizophrenia, bipolar disorders, sever personality disorders) and 12 patients with non‐advanced cancer individually participated to DT interviews. DT was tape‐recorded, transcribed verbatim and shaped into a narrative through a preliminary editing process. A session was dedicated to the final editing process along with the participant, with a final written legacy (generativity document) provided to the participant. Interpretative Phenomenological Analysis was used to qualitatively analyze the generativity documents.ResultsPatients with SMI and patients with cancer presented similar main narrative categories relative to dignity, such as “Meaning making”, “Resources”, “Legacy”, “Dignity”; in addition, inpatients with SMI “Stigma” and inpatients with cancer “Injustice" emerged as separate categories. Patients in both groups strongly appreciated DT as an opportunity to reflect on their life story and legacy.ConclusionsThe study showed that DT is a valuable intervention for people with SMI, grounded in a practical, person‐centered approach. All patients found DT as an opportunity to describe their past and present, highlighting changes in the way they relate to themselves and others. These results can guide implementation of DT in mental health settings for people with SMI, as it is for people with cancer.
Routine laboratory test to assess the need of respiratory support in acute bronchiolitis
Authors: Rodríguez‐González Moisés , Estepa‐Pedregosa Lorena , Estalella‐Mendoza Ana , Rodríguez‐Campoy Patricia , Romero‐Castillo Estefanía , Castellano‐Martínez Ana , Flores‐González Jose C. 
Published: February 2022

AbstractBackground and ObjectivesAccurate and readily available biomarkers to predict the clinical course of bronchiolitis would enable enhanced decision‐making in this setting. We explored the relationship of several biochemical parameters available at the pediatric emergency care setting with the need of advanced respiratory support (ARS): continuous positive airway pressure (CPAP), biphasic positive airway pressure (BiPAP), or invasive mechanical ventilation (MV) in bronchiolitis.MethodsSingle‐center, prospective, observational, including infants aged less than 12 months diagnosed with acute bronchiolitis at the Pediatric Emergency Department. Determination of plasmatic values of several laboratory tests was performed at the time of hospital admission. Multivariate logistic analysis identified independent predictors for need of ARS.ResultsFrom October 1, 2018 to May 1, 2020, we recruited 149 infants (58% males; median age of 1 [0.5–2.5] month). Thirty‐seven (25%) cases required ARS. After adjusting by age, bacterial superinfection, and comorbidities in the multivariate analysis, only higher levels of glycemia (p = 0.001), C‐reactive protein (CRP) (p = 0.028), CRP/albumin ratio (p = 0.032), and NT‐proBNP (p = 0.001) remained independently associated with ARS. These biomarkers reached moderate prediction accuracy with area under the curve of receiver operator curve curves ranging from 0.701 to 0.830 (p = 0.001). All they presented relatively high specificity (0.75–0.84) and negative predictive values (0.77–0.89) with low sensitivity and positive predictive values. They also correlated significantly with length of stay hospitalization (p = 0.001).ConclusionIncreased plasmatic levels of CRP, CRP/albumin ratio, glycemia, and NT‐proBNP at hospital admission are associated with the need for ARS in infants with acute bronchiolitis.
Lucidone inhibits autophagy and MDR1 via HMGB1/RAGE/PI3K/Akt signaling pathway in pancreatic cancer cells
Authors: Chen Sheng‐Yi , Hsu Yi‐Hao , Wang Sheng‐Yang , Chen Ying‐Yin , Hong Cheng‐Jie , Yen Gow‐Chin 
Published: February 2022

AbstractGemcitabine (GEM) drug resistance remains a difficult challenge in pancreatic ductal adenocarcinoma (PDAC) treatment. Therefore, identifying a safe and effective treatment strategy for PDAC is urgent. Lucidone is a natural compound extracted from the fruits of Lindera erythrocarpa Makino. However, the role of lucidone in PDAC inhibition remains unclear. In addition, high‐mobility group box 1 (HMGB1) and receptor for advanced glycation end products (RAGE) are involved in multidrug resistance protein 1 (MDR1) regulation and GEM resistance. Thus, this study aimed to explore the function of lucidone in tumor cytotoxicity and chemosensitivity through the suppression of RAGE‐initiated signaling in PDAC cells. The data showed that lucidone significantly promoted apoptotic cell death and inhibited the expression of autophagic proteins (Atg5, Beclin‐1, LC3‐II, and Vps34) and MDR1 by inhibiting the HMGB1/RAGE/PI3K/Akt axis in both MIA Paca‐2 cells and MIA Paca‐2GEMR cells (GEM‐resistant cells). Notably, convincing data were also obtained in experiments involving RAGE‐specific siRNA transfection. In addition, remarkable cell proliferation was observed after treatment with lucidone combined with GEM, particularly in MIA Paca‐2GEMR cells, indicating that lucidone treatment enhanced chemosensitivity. Collectively, this study provided the underlying mechanism by which lucidone treatment inhibited HMGB1/RAGE‐initiated PI3K/Akt/MDR1 signaling and consequently enhanced chemosensitivity in PDAC.
Effects of antioxidant co‐supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: A pilot study
Authors: Yamasaki Kazumitsu , Uchida Masahiro , Watanabe Noriko , Ihana Tatsuji , Ishiguro Yukari , Kuroda Shinnosuke , Takeshima Teppei , Yumura Yasushi , Mieno Makiko , Yoshida Kaoru , Iwamoto Teruaki , Nishiyama Hiroyuki 
Published: February 2022

AbstractPurposeIn this pilot study, the authors compared the effects of antioxidant co‐supplementation therapy and methylcobalamin therapy in patients with impaired semen quality.MethodsEighty‐four subjects who visited male infertility clinics and showed abnormal semen test results were randomly subjected to one of the two therapies: antioxidant co‐supplementation therapy with vitamin C, vitamin E, coenzyme Q10, and flaxseed oil or methylcobalamin therapy. The oxidation–reduction potential (ORP) and 8‐hydroxy‐2′‐deoxyguanosine levels were used as indicators of oxidative stress levels in semen. Semen analysis was also performed.ResultsThe authors obtained results from 67 patients who had completed 3 months of treatment. Neither antioxidant co‐supplementation therapy nor methylcobalamin therapy changed the semen parameters significantly (except for the sperm concentration, which was increased by the latter therapy). When the pre‐treatment ORP value in semen was higher than the cutoff value, both therapies significantly increased the sperm concentration. The 8‐hydroxy‐2′‐deoxyguanosine level did not yield any meaningful predictive value with regard to increased sperm concentrations.ConclusionsBoth antioxidant co‐supplementation therapy and methylcobalamin therapy increased the sperm concentration in patients with impaired semen quality when the basal ORP levels in their semen were elevated.
Disturbance observer based control for dynamically positioned ships with ocean environmental disturbances and actuator saturation
Authors: Wei Xinjiang , You Lihong , Zhang Huifeng , Hu Xin , Han Jian 
Published: February 2022

AbstractThe antidisturbance control scheme for the dynamically positioned ships with ocean environmental disturbances and actuator saturation was presented. The ocean environmental disturbances comprises slowly varying disturbances and additional stochastic disturbances. The stochastic disturbance observer was constructed to online estimate the slowly varying disturbances. Based on estimation, a stochastic antidisturbance controller was proposed by combining the disturbance observer‐based control with the stochastic control, where the actuator saturation was dealt with by the polytopic bounding technique. Furthermore, the optimal control allocation method was introduced to distribute control commands into each actuator. Finally, the ship's position and heading are maintained at the desired values and all signals of the closed‐loop system are asymptotically mean‐square bounded. And comparative simulation under different conditions demonstrates the validity and the superiority of the proposed control scheme.
Indirect adaptive control of nonlinearly parameterized nonlinear dissipative systems
Authors: Ortega Romeo , Cisneros Rafael , Wang Lei , van der Schaft Arjan 
Published: February 2022

AbstractIn this note we address the problem of indirect adaptive (regulation or tracking) control of nonlinear, input affine dissipative systems. It is assumed that the supply rate, the storage and the internal dissipation functions may be expressed as nonlinearly parameterized regression equations where the mappings (depending on the unknown parameters) satisfy a monotonicity
condition—this encompasses a large class of physical systems, including passive systems. We propose to estimate the system parameters using the “power‐balance” equation, which is the differential version of the classical dissipation inequality, with a new estimator that ensures global, exponential, parameter convergence under the very weak assumption of interval excitation of the power‐balance equation regressor. To design the indirect adaptive controller we make the standard assumption of existence of an asymptotically stabilizing controller that depends—possibly nonlinearly—on the unknown plant parameters, and apply a certainty‐equivalent control law. The benefits of the proposed approach, with respect to other existing solutions, are illustrated with examples.
Regression‐based Bayesian estimation and structure learning for nonparanormal graphical models
Authors: Mulgrave Jami J. , Ghosal Subhashis 
Published: February 2022

AbstractA nonparanormal graphical model is a semiparametric generalization of a Gaussian graphical model for continuous variables in which it is assumed that the variables follow a Gaussian graphical model only after some unknown smooth monotone transformations. We consider a Bayesian approach to inference in a nonparanormal graphical model in which we put priors on the unknown transformations through a random series based on B‐splines. We use a regression formulation to construct the likelihood through the Cholesky decomposition on the underlying precision matrix of the transformed variables and put shrinkage priors on the regression coefficients. We apply a plug‐in variational Bayesian algorithm for learning the sparse precision matrix and compare the performance to a posterior Gibbs sampling scheme in a simulation study. We finally apply the proposed methods to a microarray dataset. The proposed methods have better performance as the dimension increases, and in particular, the variational Bayesian approach has the potential to speed up the estimation in the Bayesian nonparanormal graphical model without the Gaussianity assumption while retaining the information to construct the graph.
Hierarchical Nanocellulose‐Based Gel Polymer Electrolytes for Stable Na Electrodeposition in Sodium Ion Batteries
Authors: Mittal Neeru , Tien Sean , Lizundia Erlantz , Niederberger Markus 
Published: February 2022

AbstractSodium ion batteries (NIBs) based on earth‐abundant materials offer efficient, safe, and environmentally sustainable solutions for a decarbonized society. However, to compete with mature energy storage technologies such as lithium ion batteries, further progress is needed, particularly regarding the energy density and operational lifetime. Considering these aspects as well as a circular economy perspective, the authors use biodegradable cellulose nanoparticles for the preparation of a gel polymer electrolyte that offers a high liquid electrolyte uptake of 2985%, an ionic conductivity of 2.32 mS cm−1, and a Na+ transference number of 0.637. A balanced ratio of mechanically rigid cellulose nanocrystals and flexible cellulose nanofibers results in a mesoporous hierarchical structure that ensures close contact with metallic Na. This architecture offers stable Na plating/stripping at current densities up to ±500 µA cm−2, outperforming conventional fossil‐based NIBs containing separator–liquid electrolytes. Paired with an environmentally sustainable and economically attractive Na2Fe2(SO4)3 cathode, the battery reaches an energy density of 240 Wh kg−1, delivering 69.7 mAh g−1 after 50 cycles at a rate of 1C. In comparison, Celgard in liquid electrolyte delivers only 0.6 mAh g−1 at C/4. Such gel polymer electrolytes may open up new opportunities for sustainable energy storage systems beyond lithium ion batteries.
circ_0089153 exacerbates breast cancer cells proliferation and metastasis via sponging miR‐2467‐3p/E2F6
Authors: Gao Shu‐Lan , Fan Ying , Liu Xiao‐Dan , Liu Wei , Zhao Man 
Published: February 2022

AbstractThe role of circ_0089153 in breast cancer (BCa) malignancy development was explored. circ_0089153 expression in BCa was analyzed by Gene Expression Omnibus database. Clinical tissues were obtained from 90 BCa patients. Cell counting kit‐8 assay, 5‐ethnyl‐2 deoxyuridine assay and colony formation experiment were applied for proliferation detection. Wound healing assay and Transwell experiment were used for migration and invasion detection. Dual luciferase reporter gene assay, RNA immunoprecipitation assay and RNA pull‐down assay were conducted. In vivo growth and metastasis of BCa cells were performed. Quantitative real‐time polymerase chain reaction, Western blot and immunohistochemistry were applied for RNAs and proteins expression. The up‐modulated circ_0089153 indicated an unfavorable survival of BCa patients. circ_0089153 knockdown attenuated BCa cells proliferation, migration, invasion and epithelial‐mesenchymal transition (EMT) (P < .01). circ_0089153 was miR‐2467‐3p sponge. Low miR‐2467‐3p expression indicated a worse survival of BCa patients. miR‐2467‐3p overexpression reduced BCa cells proliferation, migration, invasion and EMT (P < .05). circ_0089153 enhanced BCa cells proliferation, migration, invasion and EMT by sponging miR‐2467‐3p (P < .05). E2F6 was directly suppressed by miR‐2467‐3p. E2F6 high expression in BCa patients associated with worse survival. circ_0089153 knockdown suppressed in vivo BCa cells growth and lung metastasis (P < .01). circ_0089153 was an oncogene in breast cancer, which enhanced proliferation and metastasis through sponging miR‐2467‐3p/E2F6. circ_0089153 was suggested to be a potential target for BCa target treatment.
The Advent of Intercultural Approaches in Education
Authors: Akkari Abdeljalil , Radhouane Myriam 
Published: February 2022

AbstractNowadays, when one examines the history of the introduction of the compulsory school, our attention is drawn principally to the humanist dimension of providing schooling to everyone (but not including native and populations under colonisation), inherited from the philosophy of the Age of Enlightenment in favour of citizenship. However, we may too hastily overlook the nationalistic, Eurocentric and colonialist attitudes associated with the expansion of Western schooling.
Global Citizenship Education
Authors: Akkari Abdeljalil , Radhouane Myriam 
Published: February 2022

AbstractThe school has an indisputable role in the preparation of future generations for the exercise of citizenship. This responsibility goes well beyond the traditional national frameworks of civic instruction or education for citizenship. On the one hand, various threats which trouble our planet (ecological, economic, extremist, etc.), without precedent for some peoples and renewed for others, require that education should tackle the interdependencies and cohesions bringing all peoples and countries of the world together.
The Role of the Teacher in Promoting Intercultural Approaches
Authors: Akkari Abdeljalil , Radhouane Myriam 
Published: February 2022

AbstractTo complete this book with a chapter devoted to teachers is justified for several reasons. Firstly, the quality of a school is closely connected to the quality of its teachers. Their intellectual, moral and academic capacities are essential in our search for a more just and effective intercultural school.
Key Concepts for Intercultural Approaches
Authors: Akkari Abdeljalil , Radhouane Myriam 
Published: February 2022

AbstractThe use of intercultural approaches in education cannot be carried out without the educational actors’ appropriation of a certain number of fundamental concepts (Robles de Meléndez & Beck, 2009). In this chapter we will discuss many of the principal concepts such as culture, ethnocentrism, cultural relativism, equality and difference. This list is obviously not exhaustive, since several other concepts could have been included, such as otherness, diversity, dialogue or even universalism.
Intercultural Education in Switzerland
Authors: Akkari Abdeljalil , Radhouane Myriam 
Published: February 2022

AbstractBefore analysing the circumstances leading to the emergence of intercultural education in Switzerland, it would first be useful to explain how the country has dealt with migration. It bears, indeed, all the hallmarks of a paradox. In the first place, the country welcomes and has welcomed in the past a large number of immigrants coming for the most part from Southern Europe, but also from other regions of the world (D’Amato, 2008). This relatively ancient immigration contributed to the country’s economic prosperity. Secondly, the country’s attitude in relation to immigration has gone through periods of closing the borders and subsequently reopening them again. Thus, Switzerland has modified and adapted its policy on migration on several occasions, particularly concerning the management of the flow of migrating people (D’Amato, 2008).
Introduction: International Interdependencies and the Impact on Social Policies
Authors: Nullmeier Frank , González de Reufels Delia , Obinger Herbert 
Published: February 2022

AbstractThis chapter introduces the main concepts used in this collective volume and underlines the importance of international interdependencies for social policy development and highlights how, in recent years, social policy research has undergone far-reaching changes of which perhaps the most important concerns the scope of research, which is no longer exclusively focused on the nation state. Although the welfare state as such is a European “invention” and can be considered a child of the nation state and the Industrial Revolution, its development has also been driven by various inter- and transnational influences. These are at the centre of the contributions.
Introduction: International Organisations and Transnational Diffusion
Authors: Martens Kerstin , Niemann Dennis 
Published: February 2022

AbstractInternational organisations (IOs) have long been vibrant actors that influence global governance and transnational diffusion processes of social policies. IOs use a variety of mechanisms to influence international spheres and national policy-making processes. A few are able to distribute financial resources and implement projects, which directly affect people’s lives, and they may also (re)direct national social policies. Many other IOs active in global social policy rather exert soft governance and act as regionally or globally active think tanks that develop and diffuse ideas and norms about social policy issues. Moreover, such IO-induced norms may also become global norms and affect not only member states but all states. This chapter provides a brief overview about current research on IOs in the domain of social policies.
Global “Cultural Spheres” and the Introduction of Compulsory Schooling Around the World
Authors: Besche-Truthe Fabian , Seitzer Helen , Windzio Michael 
Published: February 2022

AbstractThis study investigates the diffusion of compulsory education in a global perspective. Compulsory education closely relates to the reproduction and change of culture and moderates the process of modernisation. We analyse the diffusion of compulsory education by focusing on the effect of a country’s membership in different "cultural spheres". Global cultural clusters of countries do not have rigid, clear-cut "fault lines". We capture the fuzzy-set nature of "cultural spheres" by using a relational approach. In the resulting network countries increasingly connect with a higher amount of cultural characteristics they share. We test the impact of cultural spheres on diffusion controlling for indicators of economic development. Exposure in terms of close cultural ties to other countries with compulsory education, significantly and substantially increases the rate of adoption.
The ILO Beyond Philadelphia
Authors: Hahs Jenny 
Published: February 2022

AbstractThe expansion of the International Labour Organization (ILO’s) body of norms between 1945 and 1970 remains unique. However, little quantitative research has been done to date on how universalising ideas of the Declaration of Philadelphia of 1944 are reflected in the adoptions of the following period and are challenged by conflicting normative developments, such as the simultaneous evolution of segmenting instruments oriented towards a “Standard Employment Relationship” (SER) of a Global North origin. The article traces the adoption developments of ILO conventions and situates them along central historical developments (colonialism, changes in membership structure). It argues that the ILO helped to foster an ideal concept of employment, namely the SER, whose regulatory ideas stemmed historically from the Global North and became spread through worldwide ratifications of ILO conventions.
The Role of the United Nations in Promoting the Policy Debate on Child Allowance Issues in 1960s Japan
Authors: Sugita Naho 
Published: February 2022

AbstractIn the 1950s, the UN began to use the concept of social development, in contrast to economic development. Social development as adapted to Japan brought a dramatic change in Japanese policy debates on human resources and social security. In this chapter, I discuss the role of the idea of social development in promoting the policy debate towards introducing child allowance in Japan. Social development as a Japanese concept was combined with an interest to improve “the quality of population”, in particular through the state’s role in family planning, while the UN’s concept encompassed a more general humanism or psychosocial well-being.
World Bank Intervention and Introduction of Social Health Insurance in Albania
Authors: Druga Ertila 
Published: February 2022

AbstractThis chapter investigates the influence of the World Bank in the formulation of Social Health Insurance law in Albania. Findings suggest that in the case of Albania, although the external influence was not able to determine the policy choice, it did, however, to some extent, shape policy formulation. The World Bank offered its expertise and assistance in formulating details of related law and defining the parameters of the future contributory system. Another important finding relates to the position of the World Bank in preserving the model of financing health through general tax revenues. That is contrary to the expectation that any idea uttered by the World Bank is neoliberal.