bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reciclagem de copos descartáveis de poliestireno pós-consumo para construção de luminárias pendentes
Authors: Knopik Ana Paula , Silva Gabryel Emed da , Almeida Michelle Campos de , Zuclinski Marciel José , Kloss Juliana Regina 
Published: February 2022

A crescente utilização de materiais poliméricos descartáveis, contrapondo o tempo longo de decomposição, torna necessário pensar em propostas para minimizar o impacto ambiental decorrente do descarte inadequado na natureza. Dessa forma, uma das alternativas é a reciclagem mecânica, possibilitando o resíduo ter viabilidade comercial. Nessa perspectiva o presente trabalho teve como objetivo construir luminárias de poliestireno (PS) reciclado mecanicamente a partir de copos descartáveis. Os copos foram recolhidos quinzenalmente durante seis meses, submetidos à triagem e secagem. Em seguida, triturados, processados via extrusão, granulados e processados via injeção. Os materiais foram analisados através das seguintes técnicas: espectroscopia na região do infravermelho, ensaio mecânico de tração, teste de chama, teste de ausência de cloro (teste de Beilstein) e teste prévio de amarelamento. Foram comparados o PS cristal virgem e o PS reciclado. Após a caracterização, os corpos de prova foram perfurados para construção da luminária pendente. Os resultados dos testes de chama e de Beilstein foram muito satisfatórios. Já as análises de propriedades mecânicas, devido a possível presença de aditivos na composição dos copos descartáveis e/ou a utilização de um porcentagem de poliestireno de alto impacto, apresentaram resultados referentes a um material reciclado mais elástico, tornando neste caso a luminária mais resistente. As análises de espectroscopia na região do infravermelho, em comparação com outros estudos já realizados para o PS, mostraram resultados muito similares. Em relação ao teste prévio de amarelamento, visualmente nenhuma alteração foi identificada. Portanto, a construção de luminárias pendentes mostrou-se uma alternativa eficaz e sustentável para copos descartáveis pós-consumo.
Curva de absorção de nutrientes em jambu (spilanthes oleracea l.), cultivado em sistema hidropônico
Authors: Araújo Jayne Martins , Cunha Hudson Pierre da Silva , Nascimento Casais Luana Keslley , Aviz Rhaiana Oliveira de , Ponce Franciely da Silva , Nunes Kelly de Nazaré Maia , Araújo Leonardo Amaral , Borges Luciana da Silva 
Published: February 2022

O jambu é uma hortaliça folhosa que vem ganhando o mercado nacional e internacional, muito atrelado aos seus princípios ativos, com isso, vem aumentando a diversificação da sua produção, como por exemplo, em sistema hidropônico. Objetivou-se com essa pesquisa analisar a curva de absorção de nutrientes em plantas de jambu, cultivadas em sistema hidropônico. Os experimentos foram conduzidos no sitio da empresa B&A Hidroponia em sistema de cultivo hidropônico NFT em ambiente protegido. Os tratamentos consistiram em 06 coletas com 03 repetições cada, realizadas em um intervalo de 05 em 05 dias. O delineamento experimental utilizado foi o inteiramente casualizado com seis tratamentos (seis coletas) e três repetições. A ordem decrescente dos macronutrientes acumulados pela planta de jambu foi: nitrogênio > potássio > cálcio > fósforo > magnésio > enxofre, e de micronutrientes: sódio > alumínio > ferro > boro > manganês > zinco > cobre, com período de maior crescimento e demanda de nutrientes de 39º a 54º dias após a semeadura. O teor de clorofila está interligado a absorção dos nutrientes pelas plantas de jambu. Desta forma a solução nutritiva utilizada se mostrou inadequada para a cultura nesse sistema, o que acarreta em perdas de produtividade entre as janelas de produção, e impedindo que a cultura atenda seu máximo potencial produtivo, e consequentemente maiores retornos financeiros. Desta forma é necessária uma formulação da solução nutritiva especifica para a planta de jambu cultivada em sistema hidropônico.
Social inequality and the SARS-CoV-2 in Brazil: How prepared are Brazilâ€™s municipalities in health infrastructure to tackle the disease?
Authors: Moreira Rodrigo Martins , Montoya Alejandra Carolina Villa , Araujo Sara Line Silveira , Trindade Rafaela Aparecida , Oliveira Dara da Cunha , Marinho Guilherme de Oliveira 
Published: February 2022

The emergence of new diseases such as SARS-CoV-2 is a reflection of the expansion of anthropic activities on natural ecosystems. The first case in Brazil was reported in February and the number of confirmed cases and the death rate is increasing at an alarming rate. In this context, this study aims to answer two main questions: is social inequality related to SARS-CoV-2 confirmed cases and death rate and how distributed is the health infrastructure in Brazil to tackle the SARS-CoV-2 disease, relating directly to the third UNâ€™s Sustainable Development Goal, Good Health and Well-being. To this purpose, the researchers applied the Moranâ€™s Bivariate Local Spatial Autocorrelation Index to assess the relationship between Gini coefficient with confirmed SARS-CoV-2 cases and the death rate of the disease and the Global Moran Index to assess the distribution of health infrastructure to tackle the disease. We focused on obtaining results that allow decision-making in the health and government sectors. The results display an imbalance between demand and supply, with precarious health infrastructure for people with severe symptoms and increased deaths. SARS-CoV-2 is spreading fast throughout Brazil, and the north and northeast region need special attention due to its lack of health infrastructure. Cartographic products are essential to decision making in epidemiological studies.
Out of Touch
Authors: Drouin Michelle 
Published: February 2022

A behavioral scientist explores love, belongingness, and fulfillment, focusing on how modern technology can both help and hinder our need to connect. A Next Big Idea Club nominee.
Millions of people around the world are not getting the physical, emotional, and intellectual intimacy they crave. Through the wonders of modern technology, we are connecting with more people more often than ever before, but are these connections what we long for? Pandemic isolation has made us even more alone. In Out of Touch, Professor of Psychology Michelle Drouin investigates what she calls our intimacy famine, exploring love, belongingness, and fulfillment and considering why relationships carried out on technological platforms may leave us starving for physical connection. Drouin puts it this way: when most of our interactions are through social media, we are taking tiny hits of dopamine rather than the huge shots of oxytocin that an intimate in-person relationship would provide.
Drouin explains that intimacy is not just sex—although of course sex is an important part of intimacy. But how important? Drouin reports on surveys that millennials (perhaps distracted by constant Tinder-swiping) have less sex than previous generations. She discusses pandemic puppies, professional cuddlers, the importance of touch, “desire discrepancy” in marriage, and the value of friendships. Online dating, she suggests, might give users too many options; and the internet facilitates “infidelity-related behaviors.” Some technological advances will help us develop and maintain intimate relationships—our phones, for example, can be bridges to emotional support. Some, on the other hand, might leave us out of touch. Drouin explores both of these possibilities.
Antioxidant and anti-inflammatory activities of durian (Durio zibethinusMurr.) pulp, seed and peel flour
Authors: Charoenphun Narin , Klangbud Wiyada Kwanhian 
Published: February 2022

The unripe pulp, inner peel and seed of durian were used in this study. These are generally not considered edible and must be disposed of as waste. However, they are good sources of bioactive compounds. Flour extracts from the unripe pulp, inner peel, and seed of two durian (Durio zibethinusMurr.) varieties, namely, Monthong and Chanee, were analyzed chemically to determine their total phenolic content (TPC), antioxidant, and anti-inflammatory capacities. Chanee pulp (CPu) contained a higher TPC (5285.37 ± 517.65 mg GAE/g) than Monthong pulp (MPu), Monthong peel (MP), Monthong seed (MS), Chanee peel (CP) and Chanee seed (CS) (p = 0.0027, 0.0042, 0.0229, 0.0069 and 0.36), respectively. The antioxidant activity of each durian extract was determined against ABTS, nitric oxide, superoxide, hydroxyl, and metal ions. The results indicated that the pulp, inner peel and seed of these durian varieties had antioxidant capacities. Murine Raw 264.7 macrophages were used to determine the cytotoxicity of the flour extracts. The extract of CS flour had the lowest cytotoxicity followed by MP, CPu, CP, MPu and MS (p = 0.5926, 0.44, 0.3191, 0.1471 and 0.0014), respectively. The anti-inflammatory activity was tested by anti-nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated cells by co-treating the Raw 264.7 cells with each durian flour extract and LPS. The extract of MP flour had the lowest IC50against NO production, indicating the highest anti-NO production activity followed by CS, CPu, MPu, CP and MS (p = 0.7473, 0.0104, < 0.0001, 0.0002 and < 0.0001, respectively). The information obtained in this study is useful for researchers to explore more durian varieties in Southeast Asia to find bioactive compounds that might be novel nutraceuticals for antioxidant, anti-inflammation and therapeutic functional food.
A Study Protocol on Assessment of Heart Rate Variability as a Prognostic Marker in Critically Ill Patients
Authors: Kakde Yogesh Kautikrao , Gaidhane Shilpa , Acharya Sourya , Kumar Sunil , Amrutha . 
Published: February 2022

Background: Calculation of heart rate variability (HRV) is the most popular approach of actual evaluation of autonomic nervous system (ANS) dysregulation, representing natural physiological changes. The natural changes take place in the interim among successive heart beats when sympathetic and parasympathetic expression is balanced on the heart's electrical conduction system. Numerous adult studies have shown that reductions in HRV predate clinical decline, indicate therapy response in correlation with results. Therefore, HRV can be functional as a measure of more accurate clinical perception. This study aims to determine role of heart rate variability and other risk factors as a prognostic marker for 90-day survival among patients admitted to critical care units.
Methods: This will be an Observational Cross-sectional Study with Control Group and will include hypertension, diabetes mellitus, Myocardial Infarction, Stroke, Sepsis cases and control cases. The patients admitted in Medicine critical care unit will be included in the study and they will be evaluated for HRV and APACHE IV scoring. Patients demographic profile, anthropometric measurements and history of other comorbid conditions will be documented. Patients’ outcome indicators like duration of hospital stay, 90-day survival and mortality will be obtained .Data will be analyzed by appropriate statistical tests.
Expected Results: Mixed effects models will demonstrate that the result of three HRV will be relatively lower from the start of day and night compared to the last day and night of MICU admission. The significant relationship between the variability of time from enrollment and log heart rate values is expected over the last day and night of MICU stay. Also, average HRV is expected to persist significantly higher as compared with that of the first day and night.
Role of Protein–Lipid Interactions in Viral Entry
Authors: Nieto‐Garai Jon Ander , Contreras Francesc‐Xabier , Arboleya Aroa , Lorizate Maier 
Published: February 2022

AbstractThe viral entry consists of several sequential events that ensure the attachment of the virus to the host cell and the introduction of its genetic material for the continuation of the replication cycle. Both cellular and viral lipids have gained a wider focus in recent years in the field of viral entry, as they are found to play key roles in different steps of the process. The specific role is summarized that lipids and lipid membrane nanostructures play in viral attachment, fusion, and immune evasion and how they can be targeted with antiviral therapies. Finally, some of the limitations of techniques commonly used for protein–lipid interactions studies are discussed, and new emerging tools are reviewed that can be applied to this field.
Nanosphere Lithography: A Versatile Approach to Develop Transparent Conductive Films for Optoelectronic Applications
Authors: Qiu Tengfei , Akinoglu Eser Metin , Luo Bin , Konarova Muxina , Yun Jung‐Ho , Gentle Ian R. , Wang Lianzhou 
Published: February 2022

AbstractTransparent conductive films (TCFs) are irreplaceable components in most optoelectronic applications such as solar cells, organic light‐emitting diodes, sensors, smart windows, and bioelectronics. The shortcomings of existing traditional transparent conductors demand the development of new material systems that are both transparent and electrically conductive, with variable functionality to meet the requirements of new generation optoelectronic devices. In this respect, TCFs with periodic or irregular nanomesh structures have recently emerged as promising candidates, which possess superior mechanical properties in comparison with conventional metal oxide TCFs. Among the methods for nanomesh TCFs fabrication, nanosphere lithography (NSL) has proven to be a versatile platform, with which a wide range of morphologically distinct nanomesh TCFs have been demonstrated. These materials are not only functionally diverse, but also have advantages in terms of device compatibility. This review provides a comprehensive description of the NSL process and its most relevant derivatives to fabricate nanomesh TCFs. The structure‐property relationships of these materials are elaborated and an overview of their application in different technologies across disciplines related to optoelectronics is given. It is concluded with a perspective on current shortcomings and future directions to further advance the field.
A Two‐Pathway Model for the Evolution of Colloidal Compound Semiconductor Quantum Dots and Magic‐Size Clusters
Authors: Li Yang , Rowell Nelson , Luan Chaoran , Zhang Meng , Chen Xiaoqin , Yu Kui 
Published: February 2022

AbstractA fundamental understanding of formation pathways is critical to the controlled synthesis of colloidal semiconductor nanocrystals. As ultrasmall‐size quantum dots (QDs) sometimes emerge in reactions along with magic‐size clusters (MSCs), distinguishing their individual pathway of evolution is important, but has proven difficult. To decouple the evolution of QDs and MSCs, an unconventional, selective approach has been developed, along with a two‐pathway model that provides a fundamental understanding of production selectivity. For on‐demand production of either ultrasmall QDs or MSCs, the key enabler is in how to allow a reaction to proceed in the time prior to nucleation and growth of QDs. In this prenucleation stage, an intermediate compound forms, which is the precursor compound (PC) to the MSC. Here, the two‐pathway model and the manipulation of such PCs to synthesize either ultrasmall QDs or binary and ternary MSCs are highlighted. The two‐pathway model will assist the development of nucleation theory as well as provide a basis for a mechanism‐enabled design and predictive synthesis of functional nanomaterials.
WS2/Bi2O2Se van der Waals Heterostructure with Straddling Band Configuration for High Performances and Broadband Photodetector
Authors: Fang Chaocheng , Han Jianfu , Yu Ming , Liu Wenliang , Gao Shengmei , Huang Kai 
Published: February 2022

Abstract2D bismuth oxyselenide (Bi2O2Se) nanosheets have received increasing attention in the field of electronics and optoelectronics due to their high‐mobility, moderate energy bandgap, and air‐stability. However, due to the intrinsic high mobility, the photodetectors based on 2D Bi2O2Se have an inevitable high dark current, leading to high power consumption and limiting its potential application in photodetection. Herein, a novel highly sensitive WS2/Bi2O2Se van der Walls (vdWs) heterostructure with straddling band configuration is assembled on fluorophlogopite substrate. Owing to the effective separation of photogenerated electron–hole pairs and the quantum tunneling effect, the responsivity and external quantum efficiency of the WS2/Bi2O2Se heterostructure are 628 mA W−1 and 147.6% under 532 nm illumination, respectively. The Iphoto/Idark ratio with more than two orders of magnitude can be obtained, and the rise time is ≈33 ms, while the fall time is 38 ms. Furthermore, the heterostructure achieves a broadband photodetection capability from visible to near infrared (532–1450 nm). The results suggest that the WS2/Bi2O2Se vdWs heterostructure possesses a promising potential application prospect in high performance and broadband photodetectors.
Photoinactivation of Catalase Sensitizes Candida albicans and Candida auris to ROS‐Producing Agents and Immune Cells
Authors: Dong Pu‐Ting , Zhan Yuewei , Jusuf Sebastian , Hui Jie , Dagher Zeina , Mansour Michael K. , Cheng Ji‐Xin 
Published: February 2022

AbstractMicrobes have developed their own specific strategies to cope with reactive oxygen species (ROS). Catalase, a heme‐containing tetramer expressed in a broad range of aerobic fungi, shows remarkable efficiency in degrading hydrogen peroxide (H2O2) for fungal survival and host invasion. Here, it is demonstrated that catalase inactivation by blue light renders fungal cells highly susceptible to ROS attack. To confirm catalase as a major molecular target of blue light, wild type Candida albicans are systematically compared with a catalase‐deficient mutant strain regarding their susceptibility to ROS through 410 nm treatment. Upon testing a wide range of fungal species, it is found that intracellular catalase can be effectively and universally inactivated by 410 nm blue light. It is also found that photoinactivation of catalase in combination with ROS‐generating agents is highly effective in total eradication of various fungal species, including multiple Candida auris strains, the causative agent of the global fungal epidemic. In addition, photoinactivation of catalase is shown to facilitate macrophage killing of intracellular Candida albicans. The antifungal efficacy of catalase photoinactivation is further validated using a C. albicans‐induced mouse model of skin abrasion. Taken together, the findings offer a novel catalase‐photoinactivation approach to address multidrug‐resistant Candida infections.
Monitoring the Remodeling of Biohybrid Tissue‐Engineered Vascular Grafts by Multimodal Molecular Imaging
Authors: Rama Elena , Mohapatra Saurav Ranjan , Melcher Christoph , Nolte Teresa , Dadfar Seyed Mohammadali , Brueck Ramona , Pathak Vertika , Rix Anne , Gries Thomas , Schulz Volkmar , Lammers Twan , Apel Christian , Jockenhoevel Stefan , Kiessling Fabian 
Published: February 2022

AbstractTissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts’ structural integrity, physiological function, and remodeling during the entire transition between late in vitro maturation and early in vivo engraftment are mandatory for clinical implementation. Thus, a comprehensive molecular imaging concept using magnetic resonance imaging (MRI) and ultrasound (US) to monitor textile scaffold resorption, extracellular matrix (ECM) remodeling, and endothelial integrity in TEVGs is presented here. Superparamagnetic iron‐oxide nanoparticles (SPION) incorporated in biodegradable poly(lactic‐co‐glycolic acid) (PLGA) fibers of the TEVGs allow to quantitatively monitor scaffold resorption via MRI both in vitro and in vivo. Additionally, ECM formation can be depicted by molecular MRI using elastin‐ and collagen‐targeted probes. Finally, molecular US ofαvβ3integrins confirms the absence of endothelial dysfunction; the latter is provocable by TNF‐α. In conclusion, the successful employment of noninvasive molecular imaging to longitudinally evaluate TEVGs remodeling is demonstrated. This approach may foster its translation from in vitro quality control assessment to in vivo applications to ensure proper prostheses engraftment.
Proposed clinical approach and imaging studies in families with oculo‐auriculo‐vertebral spectrum to assess variable expressivity
Authors: Estandia‐Ortega Bernardette , Fernández‐Hernández Liliana , Alcántara‐Ortigoza Miguel Angel , González‐del Angel Ariadna 
Published: February 2022

AbstractA diagnosis of oculo‐auriculo‐vertebral spectrum (OAVS) is established when microtia is present in association with hemifacial hypoplasia (HH) and/or ocular, vertebral, and/or renal malformations. There is no consensus on which imaging studies should be used to rule out variable expressivity and distinguish “sporadic” from “familial” patients. This observational and descriptive study was performed in a Mexican population of 51 patients (32 males, 19 females, 0–18 years old) with microtia/OAVS, and their available parents. A clinical history, genealogy, and physical examination were obtained from all included patients, as were a computed tomography (CT) scan of the ear, audiological evaluation, orthopantomography, complete spine radiography, and renal ultrasound. The same approach was completed in their available parents (51 mothers and 40 fathers), excluding the CT scan and audiological evaluation. By genealogy, 53% of patients were classified as “sporadic”; of the “familial” patients, at least 79.1% had suggestion of a multifactorial inheritance. In the available parents, orthopantomography, complete spine X‐ray, and renal ultrasound identified the following OAVS‐related manifestations: HH (16.2%, n = 14/86), vertebral alterations (10.9%, n = 10/91), and renal anomalies (2.2%, n = 2/90). Our evaluation of the parents allowed three patients to be reclassified from “sporadic” to “familial” (5.8%, n = 3/51). Our proposed clinical and imaging approach allowed the identification of variable expressivity that more clearly distinguished between “sporadic” and “familial” OAVS patients, which is of utmost importance in providing proper genetic counseling to these families.
Enantioselective Iridium‐Catalyzed Reductive Coupling of Dienes with Oxetanones and N‐Acyl‐Azetidinones Mediated by 2‐Propanol
Authors: Meyer Cole C. , Dubey Zachary J. , Krische Michael J. 
Published: February 2022

AbstractCyclometallated iridium‐PhanePhos complexes generated in situ from [Ir(cod)Cl]2 and (R)‐PhanePhos catalyze 2‐propanol‐mediated reductive couplings of 2‐substituted dienes with oxetanone and N‐acyl‐azetidinones to form branched homoallylic oxetanols and azetidinols with excellent control of regio‐ and enantioselectivity without C−C cleavage of the strained ring via enantiotopic π‐facial selection of transient allyliridium nucleophiles. This work represents the first systematic study of enantioselective additions to symmetric ketones.