bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of prognostic signature of patients with oral squamous cell carcinoma based on pyroptosis-related long non-coding RNAs
Authors: Xin Yuqi , Zhang Jieyuan , Jiang Qingkun , Qiu Jiaxuan 
Published: August 2022

Background and objectiveOral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck, and its morbidity and mortality are increasing year by year. Changes in key genes are thought to be closely related to the occurrence and development of OSCC. Pyroptosis is an inflammatory form of programmed cell death that has been implicated in malignancies and inflammatory diseases. Changes in the expression of long noncoding RNAs may also affect tumorigenesis and progression. In this study, our main objective was to evaluate the association between pyroptosis-related lncRNAs and prognosis in patients with OSCC.MethodsThe RNA-seq data and clinicopathological data of OSCC patients are from The Cancer Genome Atlas database. The pyroptosis gene set is obtained from Gene Set Enrichment Analysis database. Univariate COX, Lasso and multivariate COX regression analyses were used for the construction of risk prognostic models of OSCC, eight lncRNAs were incorporated into prognostic models. The Kaplan-Meier method and log-rank test were used to evaluate the differences of overall survival between patients in high-risk and low-risk groups. The reliability of predictions across the dataset was analyzed by receiver operating characteristic (ROC) curves. The immune signature score was calculated using the single-sample gene set enrichment analysis.ResultsEight pyroptosis-related lncRNAs were used to construct prognostic signature of OSCC, including AC136475.2, AC024075.2, JPX, ZFAS1, TNFRSF10A-AS1, LINC00847, AC099850.3 and IER3-AS1. According to this prognostic signature, patients with OSCC were divided into high-risk and low-risk groups. Kaplan-Meier survival analysis showed that the survival rate of the high-risk group was significantly lower than the low-risk group. ROC area for risk score was 0.716, and ROC area of the 8 lncRNAs are all between 0.5 and 1, implied that these lncRNAs had high accuracy in predicting the prognosis of OSCC patients. Immune Infiltration findings suggested that these lncRNAs affected immune responses in the microenvironment of OSCC.ConclusionThe prognostic signature based on pyroptosis-related lncRNAs potentially serves as an independent prognostic indicator for OSCC patients. And this signature facilitates research on targeted diagnosis and treatment of patients diagnosed with OSCC.
De la source à l’image : y a-t-il une philologie numérique ?
Authors: Giovacchini Julie 
Published: August 2022

Cet article s'intéresse à la place qu occupe la numérisation des images des sources manuscrites dans les pratiques philologiques actuelles. Pourquoi la philologie classique est elle une discipline dont l exercice nécessite un accès, quelle
que soit la forme de cet accès, à de telles images ? Quels sont les gains liés à l'émergence de ressources numériques pour l'édition des textes antiques ? Quelles sont les limites inhérentes à ces supports virtuels ? La révolution numérique modifie profondément le monde de la philologie classique, et soulève des questions nouvelles en tentant d en résoudre de très anciennes.
Molecular Phylogenetics Reveals Multiple Transitions to Self-Compatibility in a Primary Subclade of Oenothera (Onagraceae)
Authors: Krakos Kyra N. , Johnson Matthew G. , Hoch Peter C. , Wagner Warren L. , Huang Pu , Raven Peter H. 
Published: August 2022

Evolutionary shifts in breeding system are thought to have played key roles in the diversification of many lineages of plants, including the evening primrose family (Onagraceae), which includes the genus Oenothera L. Diversification in Oenothera has been accompanied by frequent breeding system shifts, but it is not clear whether these differences are due to shared evolutionary history or reflect repeated independent adaptations to varying ecological conditions. In this study, we focus on “Subclade B,” one of two primary clades within Oenothera, and combine phylogenetic reconstructions and breeding system data to evaluate evidence for multiple transitions to self-compatibility. This study includes 46 of the 58 named taxa (species and subspecies) of Oenothera Subclade B. Some taxa were sequenced in earlier analyses, available from GenBank, one was resampled here to add new sequences, and 28 taxa are newly sequenced here. We base our phylogeny on sequencing of portions of four chloroplast markers (rps16, ndhF, trnL-F, and rbcL) and two nuclear genes (ITS and ETS). We used pollination tests to verify or determine the breeding system of these taxa.
Our phylogeny supports the current classification of Oenothera with minor changes and provides greater insight and clarity to the relationships of these species. Our results provide support for the monophyly of most of the sections in Oenothera Subclade B, as well as greater resolution for topology within sections Gaura (L.) W. L. Wagner & Hoch, Hartmannia (Spach) Walpers, Kneiffia (Spach) Walpers, and Megapterium (Spach) Walpers. Relationships among these monophyletic lineages, and the placement of sections Paradoxus W. L. Wagner and Peniophyllum (Pennell) Munz, and of the allopolypoid O. hispida (Benth.) W. L. Wagner, Hoch & Zarucchi, are not uniformly well-supported and need further clarification, but these phylogenetic uncertainties had minimal impact on the inference of transitions in self-compatibility in Subclade B.
We use maximum likelihood, Bayesian inference and stochastic character mapping to estimate the minimum and maximum number of transitions necessary to explain the phylogenetic distribution of self-compatible lineages. Our results confirm at least 12 and possibly up to 15 independent transitions from self-incompatibility to self-compatibility in Oenothera Subclade B. This lability in breeding system, which is also seen broadly across Oenothera, lends strong support to the hypothesis that this trait plays a key role in the diversification of the genus.
Descriptive Analysis of Human Resource Development Through Motivation and Training as Well As Supporting and Inhibiting Factors
Authors: Saidi Arbainah , Habibi Muhammad 
Published: August 2022

The purpose of this study is to describe and analyze the factors inhibiting and supporting human resource development at the Kerta Buana Village Office, Tenggarong Seberang District, Kutai Kartanegara Regency. The research method used in this study is a qualitative descriptive research approach. In this study, researchers used information as a source to obtain data. Primary data is data obtained from information while secondary data is data obtained from documents at the research location. In this study, researchers used interactive model data analysis from Milles and Huberman. Based on the results of research in the field that the Development of Human Resources in Public Implementation at the Kerta Buana Village Office, Tenggarong Seberang District, Kutai Kartanegara Regency, shows that the motivation given to village officials/staff by the village head is to encourage the improvement of education from senior high schools to a higher level, namely universities and training held by the District Government through the District Government followed by the Village Government with sending its staff to always attend training by providing opportunities to attend training in order to develop and improve knowledge in public services through training on archive governance, making rural regulations and developing technology in the field of e-administrative applications while supporting and inhibiting factors for human resource development at the Kerta Buana Village Office, Tenggarong Seberang District, are the facilities owned by the Village Office such as service counters, facilities and infrastructure.
SWOT Analysis Counseling In Dealing With Business Competition Following The COVID-19 Pandemic
Authors: Hadian Arief , Syamsuri Abd. Rasyid 
Published: August 2022

Following Covid-19, many business actors find it challenging to maintain a competitive edge in their industries, particularly in North Sumatra Province's Hamlet I, Dalu 10 A Village, Tanjung Morawa District, and Tanjung Morawa Village. SWOT analysis is utilized as a part of counseling and is a solution to issues faced by business players in the Dusun I area of Dalu Village 10 A so that they can apply an understanding of competitive strategy. A planning tool called a SWOT analysis can be used to recognize, evaluate, and account for potential internal and external issues that may impair a company's ability to carry on with its operations. The preparation stage, the field activity implementation stage, and the activity evaluation stage are the stages of this counseling activity. Lectures and conversations are the methods employed in this counseling activity. The accomplishment of outcomes in developing material understanding in the form of creating business plans utilizing SWOT analysis is the outcome of this activity Abstrak Pasca Covid-19, banyak pelaku usaha yang kesulitan bersaing dalam menjalankan usahanya, khususnya yang berada di Dusun I, Desa Dalu 10 A, Kecamatan Tanjung Morawa, Kabupaten Deli Serdang, Provinsi Sumatera Utara. Agar para pelaku usaha dapat menerapkan pemahaman tentang strategi bersaing, analisis SWOT digunakan sebagai bagian dari penyuluhan dan menjadi solusi permasalahan yang dihadapi oleh pelaku usaha di wilayah Dusun I Desa Dalu 10 A. Analisis SWOT merupakan teknik perencanaan yang dapat digunakan untuk mengidentifikasi, menilai, dan memperhitungkan potensi masalah internal dan eksternal serta dapat mempengaruhi kapasitas suatu usaha untuk melanjutkan operasinya. Tahap persiapan, tahap pelaksanaan kegiatan lapangan, dan tahap evaluasi kegiatan merupakan tahapan dari kegiatan penyuluhan ini. Ceramah dan diskusi adalah metode yang digunakan dalam kegiatan konseling ini. Tercapainya luaran dalam mengembangkan pemahaman materi berupa pembuatan rencana usaha dengan menggunakan analisis SWOT merupakan hasil dari kegiatan ini.
HUBUNGAN KUALITAS SEDIAAN BAKTERI TAHAN ASAM (BTA) TERHADAP HASIL DIAGNOSIS PASIEN TUBERKULOSIS PARU
Authors: Niken Niken , Darma Ika Yulia , Yulia Hendra 
Published: August 2022

ABSTRACT

Background:Based on observations, it was found that patients with suspected TB did sputum examination, but saliva samples were given, so that the quality of the smear preparations was poor and caused false negative results. Patients are advised to give a new sample in the form of mucopurulent so that a better AFB preparation is obtained and the actual results are obtained.
Methods: This study aims to determine the quality of acid proof bacteria preparations on the results of the diagnosis of pulmonary tuberculosis patients at Yos Sudarso Hospital, Padang. The research design was cross sectional. Samples were sputum samples from 60 patients. Univariate analysis was conducted to see the frequency distribution of each variable. Bivariate analysis is a statistical analysis used to find the relationship between the quality of acid proof bacteria preparations and the diagnosis of pulmonary TB patients at Yos Sudarso Hospital, Padang. This analysis aims to find the relationship between variables with the statistical test of chi square correlation analysis
Results:The results of the study stated that the p value was 0.000, which means <0.05, so it was concluded that there was a significant relationship between the quality of acid proof bacteria preparations and the diagnosis of pulmonary tuberculosis patients.
Conclusion:The conclusion of the study, the results of the patient's diagnosis were 33 positive for TB, then the best quality of acid proof bacteria preparations was in the dimensions of size and flatness
Deep Multi-Resolution Mutual Learning for Image Inpainting
Authors: Zhang Huan , Zhang Zhao , Zhang Haijun , Yang Yi , Yan Shuicheng , Wang Meng 
Published: August 2022

<p>Please cite this work as: </p>
<p><br></p>
<p>Huan Zheng, Zhao Zhang, Haijun Zhang, Yi Yang, Shuicheng Yan and Meng Wang, "Deep Multi-Resolution Mutual Learning for Image Inpainting," In: Proceedings of the 30th ACM International Conference on Multimedia (ACM MM), Lisbon, Portugal, June 2022. </p>
Non-invasive Brain Imaging and Stimulation in Post-stroke Motor Rehabilitation: A Review
Authors: Chang Hui 
Published: August 2022

<p>Motor dysfunction is the common sequela of stroke, which seriously affects the patients’ daily life. Brain imaging is primarily employed to reconstruct the brain’s structural and functional networks to assess motor function during motor rehabilitation. Non-invasive brain imaging techniques have been widely used due to the non-surgical advantages. Electroencephalography (EEG) and magnetoencephalography (MEG) are measurements of electromagnetic feld changes during brain activity. At the same time, functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS) are measurements of hemodynamic state during brain activity. Brain network consisting of functional connectivity and effective connectivity could be established based on brain imaging. Multimodal imaging can overcome the limitation of single-mode, making the motor function assessment more comprehensive and accurate. Mathematical models are required for studying connectivity and relationships among brain areas. Brain activity can be modulated through brain stimulation to enhance motor rehabilitation based on motor function assessments. Although not yet included in clinical guidelines, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have been shown in numerous clinical trials to promote bilateral brain balance. Brain network reorganization guides therapeutic strategies integrating brain stimulations. Although brain imaging and brain stimulation on stroke motor rehabilitation are well-studied forms, a thorough between imagingbased motor assessment and stimulation-based rehabilitation strategy is still lacking. This narrative review aims to summarize the methods of motor function assessment using brain imaging and interventions for motor function rehabilitation using brain stimulation after stroke, which would be helpful to establish a closed-loop rehabilitation approach.<br>
</p>
An Exploration of an Early Gravity Transition in Light of Cosmological Tensions
Authors: Benevento Giampaolo , Kable Joshua A. , Addison Graeme E. , Bennett Charles L. 
Published: August 2022

Abstract
We study a step-like transition in the value of the effective Planck mass (or effective gravitational constant) on cosmological scales prior to recombination. We employ cosmic microwave background, baryon acoustic oscillations, and Type Ia supernova data and find they are sufficient to strongly constrain our implementation of the effective field theory of dark energy and modified gravity, used to model the transition, to a limited parameter space. The data prefer a ∼5% shift in the value of the effective Planck mass (<10% at 2σ) prior to recombination. This Transitional Planck Mass (TPM) model is free to undergo its transition at any point over multiple decades of scale factor prior to recombination,

log

10

(
a
)
=
−

5.32

−
0.72

+
0.96

(68% confidence level). This lowers the sound horizon at last scattering, which increases the Hubble constant to 71.09 ± 0.75 km s−1 Mpc−1 with a combination of local measurements as prior and to

69.22

−
0.86

+
0.67

km s−1 Mpc−1 when the prior is excluded. The TPM model improves χ
2 with respect to ΛCDM by Δχ
2 = −23.72 with the H
0 prior and Δχ
2 = −4.8 without the prior. The model allows for both H
0 > 70 kms−1 Mpc−1 and S
8 < 0.80 simultaneously with lower values of S
8 due to a reduction in the matter density Ω
m
to offset the increase in H
0 relative to ΛCDM. While this is a particular modified gravity model, studying other variants of modified gravity may be a productive path for potentially resolving cosmological tensions while avoiding the need for a cosmological constant.
Neutral Stellar Winds toward the High-mass Star-forming Region G176.51+00.20
Authors: Li Yingjie , Xu Ye , Xu Jin-Long , Liu Dejian , Li Jingjing , Lin Zehao , Jiang Peng , Bian Shuaibo , Hao Chaojie , Chen Xiuhui 
Published: August 2022

Abstract
We observed the high-mass star-forming region G176.51+00.20 using the Five-hundred-meter Aperture Spherical radio Telescope with the 19 beam tracking observational mode. This is a pilot work of searching for neutral stellar winds traced by atomic hydrogen (i.e., H i winds) using the high-sensitivity H i line toward high-mass star-forming regions where bipolar molecular outflows have been detected with high sensitivity by Liu et al. H i wind was detected in this work only in Beam 1. We find here that, similar to low-mass star formation, no matter how large the inclination is, the H i wind is likely sufficiently strong to drive a molecular outflow. We also find that the abundance of H i in the H i wind is consistent with that of the H i narrow-line self-absorption (HINSA) in the same beam (i.e., Beam 1). This implies that there is probably an internal relationship between H i winds and HINSA. This result also reinforces the assertion that H i winds and detected molecular outflows are associated with each other.
Kinematic Structure of the Large Magellanic Cloud Globular Cluster System from Gaia eDR3 and Hubble Space Telescope Proper Motions
Authors: Bennet Paul , Alfaro-Cuello Mayte , Pino Andrés del , Watkins Laura L. , van der Marel Roeland P. , Sohn Sangmo Tony 
Published: August 2022

Abstract
We have determined bulk proper motions (PMs) for 31 LMC GCs from Gaia eDR3 and Hubble Space Telescope data using multiple independent analysis techniques. Combined with literature values for distances, line-of-sight velocities, and existing bulk PMs, we extract full 6D phase-space information for 32 clusters, allowing us to examine the kinematics of the LMC GC system in detail. Except for two GCs (NGC 2159 and NGC 2210) whose high velocities suggest they are not long-term members of the LMC system, the data are consistent with a flattened configuration that rotates like the stellar disk. The one-dimensional velocity dispersions are on the order of 30 km s−1, similar to that of old stellar populations in the LMC disk. Similarly to the case for Milky Way disk clusters, the velocity anisotropy is such that the dispersion is smallest in the azimuthal direction; however, alternative anisotropies cannot be ruled out, due to distance uncertainties. The data are consistent with a single multidimensional Gaussian velocity distribution. Given the non-collisional nature of the LMC disk, this suggests that most, if not all, of the LMC GCs are formed by a single formation mechanism in the stellar disk, despite a significant spread in age and metallicity. Any accreted halo GC population is absent or far smaller in the LMC compared to the Milky Way.
Recovering the Star Formation Histories of Recently Quenched Galaxies: The Impact of Model and Prior Choices
Authors: Suess Katherine A. , Leja Joel , Johnson Benjamin D. , Bezanson Rachel , Greene Jenny E. , Kriek Mariska , Lower Sidney , Narayanan Desika , Setton David J. , Spilker Justin S. 
Published: August 2022

Abstract
Accurate models of the star formation histories (SFHs) of recently quenched galaxies can provide constraints on when and how galaxies shut down their star formation. The recent development of nonparametric SFH models promises the flexibility required to make these measurements. However, model and prior choices significantly affect derived SFHs, particularly for post-starburst galaxies (PSBs), which have sharp changes in their recent SFH. In this paper, we create mock PSBs, then use the Prospector SED fitting software to test how well four different SFH models recover key properties. We find that a two-component parametric model performs well for our simple mock galaxies, but is sensitive to model mismatches. The fixed- and flexible-bin nonparametric models included in Prospector are able to rapidly quench a major burst of star formation, but systematically underestimate the post-burst age by up to 200 Myr. We develop a custom SFH model that allows for additional flexibility in the recent SFH. Our flexible nonparametric model is able to constrain post-burst ages with no significant offset and just ∼90 Myr of scatter. Our results suggest that while standard nonparametric models are able to recover first-order quantities of the SFH (mass, SFR, average age), accurately recovering higher-order quantities (burst fraction, quenching time) requires careful consideration of model flexibility. These mock recovery tests are a critical part of future SFH studies. Finally, we show that our new, public SFH model is able to accurately recover the properties of mock star-forming and quiescent galaxies and is suitable for broader use in the SED fitting community. https://github.com/bd-j/prospector
Modeling the Photometric Variability of Alpha2 CVn with a Dynamical Magnetosphere
Authors: Pfeffer Cameron M. , McSwain M. Virginia 
Published: August 2022

Abstract
Alpha2 Canum Venaticorum (α
2 CVn) is a strongly magnetic star with peculiar chemical signatures and periodic variability that have been long attributed to the diffusion of magnetic elements through the photosphere, leading to chemical spots across the stellar surface. However, recent studies of other magnetic hot stars are consistent with magnetospheric clouds above the surface. Here we take a renewed approach to modeling α
2 CVn with a simplified dynamical magnetosphere and a tilted, offset magnetic dipole to reproduce its Transiting Exoplanet Survey Satellite variability. Our dipole model also reproduces well the magnetic surface map of α
2 CVn from Silvester et al. Its ultraviolet variability, from IUE archival spectra, is also consistent with traditional reddening models. However, other observable quantities from the system contradict the expectations of a magnetosphere, and we conclude that it is unlikely to be present in α
2 CVn.
Potential risk resulting from the influence of static magnetic field upon living organisms. Numerically simulated effects of the static magnetic field upon metalloporphyrines
Authors: Ciesielski Wojciech , Girek Tomasz , Oszczęda Zdzisław , Soroka Jacek A. , Tomasik Piotr 
Published: August 2022

Background: An attempt to recognize the effects of a static magnetic field (SMF) of varying flux density on flora and fauna.. For this purpose the influence of static magnetic field upon molecules of Mg(II), Fe(II), Fe(III), Co(II), Co(III) and Cu(II) metalloporphyrins is studied.
Methods: Computations of the effect of real SMF 0.0, 0.1, 1, 10 and 100 AFU (Arbitrary Magnetic Field Unit; here 1AMFU &gt; 1000 T) flux density were performed in silico (computer vacuum) involving advanced computational methods.
Results: The static magnetic field (SMF) decreased the stability of the metalloporphyrine molecules. This effect depended on the situation of the molecule in respect to the direction of the SMF of the Cartesian system. An increase in the value of heat of formation was accompanied by an increase in the dipole moment. It was an effect of deformations of the molecule which involved pyrrole rings holding the hydrogen atoms at the ring nitrogen atoms and the length of the C-H and N-H bonds. As a consequence, that macrocyclic ring lost its planarity.
Conclusions: SMF even of the lowest, 0.1 AMFU flux density influences the biological role of metalloporphyrines associated with their central metal atoms. This effect is generated by changes in the electron density at these atoms, its steric hindering and polarization of particular bonds from pure valence bonds possibly into ionic bonds.