bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable urban communities: Territoriality of waqf-based communal place in Kampong Cities
Authors: Rochani Agus , Yuliastuti Nany , Sudarwanto Budi 
Published: November 2022

Abstract
One of the problems in today’s urban development is the scarcity of communal spaces in settlements. The communal space is a shared space where the community performs social interactions, establishes the community, and performs collective activities in the local community. One form of local wisdom that develops in forming communal spaces is the waqf land. Almost the entire Muslim community is involved in the running of the waqf. Likewise, in the city of Semarang, with its predominantly Muslim citizens, almost all kelurahan areas have waqf land. From this waqf land various communal spaces such as places of worship, education, and social, economic, and environmental infrastructure were developed. This study aims to formulate the territoriality of communal spaces that developed from the waqf process in Kauman Village as a representation of dense settlements in Semarang City. The research uses a holistic single case study method and inductive analysis to find the common thread of spatial territoriality. The study found that territoriality was developed through the enforcement of religious values, the legality of ownership status, institutional systems, and the development of complementary spatial functions according to communal needs. This system continues to serve the needs of the community in the long term.
Utilization of waste oil palm empty fruit bunches for bioethanol through chemical-enzymatic integration process technology and towards concept the implementation of circular economy
Authors: Harihastuti N , Purnamastuti F N 
Published: November 2022

Abstract
result obtained from the application of this integration technology is the novelty of the process to make bioethanol more efficient and environmentally friendly. The innovation technology of this can be concluded to have potential in the application of circular economy to process PEFB into The growth of palm plantation area in Indonesia continues to increase with an estimated 11.67 million Ha, which can produce 33.50 million tons of CPO. For 1 ton of palm oil, 230-250 kgs of PEFB will be produced. PEFB consists of cellulose, hemicellulose, and lignin which have great potential to be reused after being converted into bioethanol. The purpose of this research is utilization of PEFB for bioethanol through an innovative chemical enzymatic integration process. The method of the research that PEFB biomass waste into bioethanol through a hydrolysis process with ammonia. The saccharification process was carried out enzymatically using the cellulase enzyme obtained on-site from T. viride and N. crassa. The WWTP unit that processes liquid waste from the bioethanol unit disain to result in biogas. The generator units that process biogas energy can be used in unit operation. The bioethanol products and produce biogas energy and can be reused for bioethanol and WWT processes.
Development and surface properties of polyamide 6 and quasicrystal composite coatings recycled via spin coating technique
Authors: de Sousa Antônia Pamela , da Silva Aline Karla Barbosa , Figueiredo Lucas Ricardo Fernandes , de Medeiros Eliton Souto , Passos Tibério Andrade , Ferreira de Oliveira Danniel , Guedes de Lima Cavalcante Danielle 
Published: November 2022

Abstract
In search to meet technological demands, material studies as well as techniques to process them have been increasing worldwide, thus seeking to unite lower processing costs, the best properties of the materials involved, reuse of resources and more sustainable means. Thus, the development of new materials, coatings and composites have stood out in the market. For this work, we fetch the development and characterization of polyamide 6 composite coatings with quasicrystalline AlCuFe fillers, recycled through the spin coating technique, since that little is known about the interaction between these two materials, which have excellent isolating properties, and little is observed about the use of this technique to produce coatings with metallic loads. The recycled AlCuFe quasicrystalline alloy was manufactured by conventional induction casting. Polyamide 6 coatings with quasicrystalline particles were developed with additions of 0, 1, 3 and 5 (% vol.) quasicrystal, via Spin Coating technique. Thermogravimetric analyses (TG), differential scanning calorimetry (CSD), average roughness (RA), contact angle, surface energy and scanning electron microscopy (SEM) were performed to characterize this material. Being observed an increase in the thermal stability of the composite, reduction in average roughness (Ra) and surface energy values, with increase in quasicrystal fraction in the polymer matrix. In addition to hydrophobicity and oleophilic character of the samples with the addition of quasicrystalline loads. It can be concluded, in general, that the Spin Coating technique is effective in the production of polyamide composite coatings 6 with recycled quasicrystals, presenting interesting surface properties with potential for further studies in innovative applications, such as semiconductors and surface coatings.
Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers
Authors: Ralevski Elizabeth , Horvath Tamas L , Shanabrough Marya , Newcomb Jenelle , Pisani Emily , Petrakis Ismene 
Published: November 2022

Abstract

Aim
The aim of this study was to examine the relationship between ghrelin levels and the subjective effects of alcohol in heavy drinkers, and to compare them to healthy controls.

Methods
Ghrelin levels were collected as part of two laboratory studies. Both groups received either IV infusion of saline or high dose of alcohol (100 mg%). In the study of heavy drinkers, ghrelin was gathered on all subjects, but data was analyzed only for participants who received placebo (N=12). Healthy controls (N=20) came from another study that collected data on family history. Ghrelin levels and measures of alcohol effects (BAES, VAS, NDS, YCS [see manuscript for details]) were collected at 4 timepoints: baseline, before infusion, during infusion and after infusion.

Results
IV alcohol significantly reduced ghrelin levels and higher fasting ghrelin levels were associated with more intense subjective alcohol effects. There were no differences in fasting ghrelin levels or subjective effects between heavy drinkers and controls. However, while both groups showed similar decline in ghrelin levels following alcohol infusion, on the placebo day, ghrelin levels in the healthy subjects increased significantly and exponentially over time while for the heavy drinkers ghrelin levels remained flat.

Conclusions
Our findings support the role of ghrelin in reward mechanisms for alcohol. Contrary to others, we found no differences in fasting ghrelin levels or subjective experiences of alcohol between heavy drinkers and healthy controls. However, the group differences on the IV placebo day may be a possible indication of ghrelin abnormalities in heavy drinkers.
scAWMV: an adaptively weighted multi-view learning framework for the integrative analysis of parallel scRNA-seq and scATAC-seq data
Authors: Zeng Pengcheng , Ma Yuanyuan , Lin Zhixiang 
Published: November 2022

Abstract

Motivation
Technological advances have enabled us to profile single-cell multi-omics data from the same cells, providing us with an unprecedented opportunity to understand the cellular phenotype and links to its genotype. The available protocols and multi-omics datasets [including parallel single-cell RNA sequencing (scRNA-seq) and single-cell ATAC sequencing (scATAC-seq) data profiled from the same cell] are growing increasingly. However, such data are highly sparse and tend to have high level of noise, making data analysis challenging. The methods that integrate the multi-omics data can potentially improve the capacity of revealing the cellular heterogeneity.

Results
We propose an adaptively weighted multi-view learning (scAWMV) method for the integrative analysis of parallel scRNA-seq and scATAC-seq data profiled from the same cell. scAWMV considers both the difference in importance across different modalities in multi-omics data and the biological connection of the features in the scRNA-seq and scATAC-seq data. It generates biologically meaningful low-dimensional representations for the transcriptomic and epigenomic profiles via unsupervised learning. Application to four real datasets demonstrates that our framework scAWMV is an efficient method to dissect cellular heterogeneity for single-cell multi-omics data.

Availability and implementation
The software and datasets are available at https://github.com/pengchengzeng/scAWMV.

Supplementary information
Supplementary data are available at Bioinformatics online.
Working Conditions and Well-Being across the COVID Pandemic in UK Social (Care) Workers
Authors: Ravalier Jermaine M , McFadden Paula , Gillen Patricia , Mallett John , Nicholl Patricia , Neill Ruth , Manthorpe Jill , Moriarty John , Schroder Heike , Curry Denise 
Published: November 2022

AbstractPrior to the COVID-19 pandemic, social work and social care practitioners had some the worst working conditions of any sector in the UK. During the pandemic, data revealed that social care occupations had higher COVID infection and mortality rates than the general population. The article reports the changing working conditions (measured via the Work-Related Quality of Life scale) and well-being (measured via the Short Warwich–Edinburgh Mental Well-being Scale) of UK social care and social workers across three timepoints between May 2020 and July 2021 through an online cross-sectional survey of working conditions and well-being. Analysis of variance demonstrated that both well-being and working conditions were significantly poorer in July 2021 (phase 3 [n = 1,606]) than the previous two phases (n = 2,523 and n = 2,424, respectively), suggesting that both working conditions and well-being worsened within the social care and social work workforce across the pandemic. Furthermore, each of career satisfaction, working conditions, control, general well-being and home–work interface predicted poorer well-being at Time 3. Whilst chronically poor working conditions can lead to poorer individual psychological and physiological health outcomes, our findings highlight continually poor conditions in this sector, with potential further impacts on organisations and the service users that social care workers support. It is therefore important that individuals, organisations and government develop mechanisms to support these critical workers during and following the pandemic.
Building a University–School–Community Partnership to Improve Adolescent Well-Being
Authors: Kimiecik Carlyn , Gonzalvo Jasmine D , Cash Shana , Goodin Drew , Pastakia Sonak 
Published: November 2022

Abstract
Adolescent health and well-being are abysmal due to low and declining physical activity rates, increasing mental health problems such as anxiety and depression, and minimal opportunities to engage in meaningful social experiences. Adolescents who live in communities that are underserved face greater risks for experiencing health disparities including lack of access to quality healthcare, nutritious foods, social support, and educational opportunities and safety. Existing efforts have been developed and implemented to address these challenges with limited success. A university–school–community approach to adolescent well-being may offer innovative strategies to improve and enhance the well-being of adolescents from communities that are underserved. A university–school–community partnership was established to implement innovative health and well-being programming for Indiana youth at a charter school. This school was founded by Purdue University to engage and provide at-risk students with the preparation for future opportunities in higher education. In addition to strategic partnerships, this partnership utilizes a prevention science approach to mitigate youth well-being risks and offers positive-oriented experiences to address them. University partners have collaborated with community organizations and relevant community partners to implement such efforts. This article outlines a collaborative evidence-based model to build sustainable well-being efforts in other schools and communities.
Lipoprotein(a)-related cardiovascular and all-cause mortalities in Korean adults
Authors: Kim Byung Jin , Lee Mi Yeon , Choi Hyo-In , Kwon Min-Jung , Kang Jeong-Gyu 
Published: November 2022

AbstractAimsThere are inconsistent results on the association between lipoprotein(a) and mortality-related outcomes due to a lack of evidence from large-scale observational studies of Asians. This study aims to evaluate the effects of lipoprotein(a) on mortality-related outcomes in the Korean population.Methods and resultsThis cohort study included 275 430 individuals (mean age: 38 years; 50.1% men) enrolled in the Kangbuk Samsung Health Study between 2003 and 2016. The median follow-up period was 6.6 years. Cox proportional hazards analysis was used to estimate the adjusted hazard ratios (HRs) for evaluating mortality risk based on lipoprotein(a) levels and specific lipoprotein(a) categories. The median lipoprotein(a) value was 18.5 mg/dL, and the proportion of lipoprotein(a) ≥50 mg/dL was 12.8%. Multivariable Cox regression analysis showed that the group with lipoprotein(a) ≥50 mg/dL had a significantly increased risk of cardiovascular mortality (HR[95% CI]: 1.83[1.26, 2.64]) and all-cause mortality (1.20[1.03, 1.41]) than the group with lipoprotein(a) &lt; 50 mg/dL without increased risk of cancer mortality (1.05[0.81, 1.34]). The relationship between lipoprotein(a) and cardiovascular mortality was significant regardless of low-density lipoprotein cholesterol. Specifically, lipoprotein(a) ≥100 mg/dL was associated with more than twice as increased a risk of cardiovascular mortality (2.45[1.12, 5.34]) than lipoprotein(a) &lt; 10 mg/dL. In subgroup analyses, there was an interaction in the relationships between the two lipoprotein(a) categories and cardiovascular mortality for only high-density lipoprotein cholesterol.ConclusionsHigh lipoprotein(a) concentration is an independent predictor of cardiovascular mortality in the Korean population, regardless of low-density lipoprotein cholesterol levels.
Cross-hole electrical resistivity tomography as an aid in monitoring marine gas hydrate reservoirs for gas recovery: an experimental simulation study
Authors: Liu Yang , Zou Changchun , Chen Qiang , Zhao Jinhuan , Li Yanlong , Sun Jianye , Liu Changling , Peng Cheng , Wu Caowei 
Published: November 2022

SUMMARY
The in situ reservoir status monitoring plays a critical role in natural gas hydrate resource production. Considering the complexity of the field environment, a simulation framework for monitoring gas hydrates with cross-hole electrical resistivity tomography (CHERT) was developed to monitor the hydrate distribution during hydrate formation and dissociation. The simulation study comprised both numerical and physical experiments. The optimal CHERT array was designed through a numerical experiment. The effect of applying CHERT was verified through a physical experiment (a high-resistivity medium and hydrate formation experiment). The results show that improper electrode layouts will lead to varying degrees of low amplitude and blur boundary. An optimal CHERT array of a 100-mm electrode rod spacing, 8-mm electrode ring spacing and 48 electrode rings was obtained. The inversion results obtained using this CHERT array scheme can easily distinguish the distribution of high-resistivity targets and yield satisfactory results in hydrate formation experiments. These findings guarantee data processing and interpretation for applying CHERT in gas hydrate experiments and fields.
A functional variant ofCD40modulates clearance of hepatitis B virus in hepatocytes via regulation of the ANXA2/CD40/BST2 axis
Authors: Chen Jiaxuan , Chen Haitao , Mai Haoming , Lou Shuang , Luo Mengqi , Xie Haisheng , Zhou Bin , Hou Jinlin , Jiang De-Ke 
Published: November 2022

AbstractMore than 250 million people in the world are chronically infected with hepatitis B virus (HBV), which causes serious complications. Host genetic susceptibility is essential for chronic hepatitis B (CHB), and our previous genome-wide association study identified a single-nucleotide polymorphism (SNP), rs1883832, in the 5′ untranslated region of CD40 predisposing to chronic HBV infection, but the underlying mechanism remains undefined. This study aimed to investigate whether rs1883832 was the real functional SNP (fSNP) of CD40 and how it modulated HBV clearance in hepatocytes. We determined the fSNP of CD40 and its regulatory protein(s) using luciferase reporter assays, electrophoretic mobility shift assay, flanking restriction enhanced pulldown and chromatin immunoprecipitation. The potential anti-HBV activity of CD40 and its downstream molecule BST2 was assessed in HBV-transfected and HBV-infected hepatoma cells and HBV-infected primary human hepatocytes. Moreover, the mechanism of CD40 was investigated by mRNA sequencing, quantitative real-time polymerase chain reaction, immunofluorescence and western blot. We revealed rs1883832 as the true fSNP of CD40 and identified ANXA2 as a negative regulatory protein that preferentially bound to the risk allele T of rs1883832 and hence reduced CD40 expression. Furthermore, CD40 suppressed HBV replication and transcription in hepatocytes via activating the JAK–STAT pathway. BST2 was identified to be the key IFN-stimulated gene regulated by CD40 after activating JAK–STAT pathway. Inhibition of JAK/STAT/BST2 axis attenuated CD40-induced antiviral effect. In conclusion, a functional variant of CD40 modulates HBV clearance via regulation of the ANXA2/CD40/BST2 axis, which may shed new light on HBV personalized therapy.
Application of health belief model in the assessment of factors affecting exercise behaviours in preventing osteoporosis
Authors: Ong Siew Chin , Low Joo Zheng , Ooi Guat See 
Published: November 2022

Abstract

Objectives
Osteoporosis is a skeletal disorder associated with weak and brittle bones, and more susceptible to fracture. Osteo-protective behaviours, such as exercise, may prevent osteoporosis. Therefore, this study aimed to assess the factors influencing the exercise behaviour in Malaysian adults and to assess their health beliefs and self-regulation in preventing osteoporosis.

Methods
A cross-sectional, self-administered questionnaire was conducted throughout Malaysia through a web-based or physical-based survey. The questionnaire consisted of three sections: demographic data, ten questions regarding social and family history related to osteoporosis and 38 questions with seven subdomains (i.e. susceptibility, seriousness, barriers, benefits, health motivation, self-efficacy and self-regulation) which measured the health belief scores and self-regulation using 5-point Likert scale. Descriptive, inferential analysis and linear regression were used to analyse the data.

Key findings
A total of 679 participants completed the questionnaire. The mean health belief score was 63.7%, which was moderate. Most participants (64.4%) perceived low susceptibility to osteoporosis [mean score = 47.0%, standard deviation (SD) = 16.2]. Participants with age 18–27 years (44.8%), single (45.0%) and monthly income &lt;RM 1000 (45.2%), perceived significant lower susceptibility to osteoporosis. Participants’ perception scores were high on the benefits of exercise (75.7%, SD = 16.4), health motivation (74.9%, SD = 17.1) and perceived low barriers to exercise (71.7%, SD = 14.9). Respondents who were at risk of osteoporosis and with family and friends diagnosed with osteoporosis obtained a higher score than those who did not.

Conclusions
The health belief score in the Malaysian population was moderate. However, the majority of participants were unaware of the susceptibility and seriousness of osteoporosis. Efforts need to be taken to break the barriers associated with exercise in preventing osteoporosis.
Pitavastatin attenuates neuropathic pain induced by partial sciatic nerve in Wistar rats
Authors: Goel Radha , Kumar Nitin , Kumar Saxena Prasoon , Pratap Singh Alok , Bana Sweeti 
Published: November 2022

Abstract

Objectives
Pitavastatin is a competitive HMG-CoA reductase inhibitor for lowering of cholesterol level and low density lipoprotein cholesterol. This study was designed to evaluate the effect of pitavastatin in neuropathic pain induced by partial sciatic nerve ligation along with neuronal changes in Wister rats.

Methods
Pitavastatin was started three days prior to the surgery and continued for 14 days The pain was determined by thermal hyperalgesia and cold allodynia. The biochemical changes were estimated at the end of the study. The levels of cytokines were measured using an ELISA test. Western blot analysis was used to detect levels of expression of JNK, p-JNK, ERK, p-ERK, p38MAPK, p-p38MAPK. The sciatic nerve was investigated histopathologically.

Key findings
Pitavastatin significantly ameliorated nerve pain induced by PSNL and also attenuated the biochemical changes in a dose-dependent manner. The levels of inflammatory mediators were inhibited by pitavastatin. There was significant improvement in sciatic nerve fibres histology. The levels of p-38, p-ERK, and p-JNK and their associated phosphorylated proteins were reduced after treatment with pitavastatin.

Conclusion
The present study indicates that treatment with pitavastatin reversed the PSNL-induced neuropathy in Wister rats and may be an additional therapeutic strategy in the management of neuropathic pain.
Recursive rules with aggregation: a simple unified semantics
Authors: Liu Yanhong A , Stoller Scott D 
Published: November 2022

AbstractComplex reasoning problems are most clearly and easily specified using logical rules, but require recursive rules with aggregation such as count and sum for practical applications. Unfortunately, the meaning of such rules has been a significant challenge, leading to many disagreeing semantics. This paper describes a unified semantics for recursive rules with aggregation, extending the unified founded semantics and constraint semantics for recursive rules with negation. The key idea is to support simple expression of the different assumptions underlying different semantics, and orthogonally interpret aggregation operations using their simple usual meaning. We present a formal definition of the semantics, prove important properties of the semantics and compare with prior semantics. In particular, we present an efficient inference over aggregation that gives precise answers to all examples we have studied from the literature. We also apply our semantics to a wide range of challenging examples, and show that our semantics is simple and matches the desired results in all cases. Finally, we describe experiments on the most challenging examples, exhibiting unexpectedly superior performance over well-known systems when they can compute correct answers.