bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design auto trajectory of passenger ship in variation of sea condition in line Ketapang - Gilimanuk of Bali strait, Indonesia
Authors: Aisjah Aulia Siti , Masroeri A A , Andika Made Widnyana , Arifin Syamsul , Bastian Ferry 
Published: February 2022

Abstract
The fleet of ferry ships crossing in the Bali Strait between Ketapang - Gilimanuk is relatively old, where when the waves are quite large and the current is strong enough the ships cannot go directly to Ketapang or vice versa. In order for the ship to reach its destination, it needs the right trajectory based on sea conditions. An automatic control system algorithm is proposed to perform an auto trajectory system. New trajectory is created base on the sea conditions. The auto trajectory system consists of steering and speed control system. The study was done by computer simulation and using of Matlab software. Simulations were carried out for various conditions of sea current speed of 3-7 knots and waves with in height of 1-1.5 meters. The auto trajectory system used of adaptive fuzzy control system to determine the proportional - integral and - derivatives (PID) gain controller. The rules in fuzzy control use the Sugeno type. The performances of control to meet IMO standards and produced 5 trajectory models for various current and wave heights, in both of the direction from the north (Java Sea) and from the south (Australian sea). The fuzzy control can keep the ship on its trajectory with the largest error of 3.93 meters when the sea current is 7 knots from the south and the sea wave height is 1.5 meters.
Numerical Simulation of Low Pressure Evaporator Modified with Vortex Generator for Improving the Heat Transfer Characteristics
Authors: Yudhatama A R , Safitra A G , Satrio D 
Published: February 2022

Abstract
Heat Recovery Steam Generator (HRSG) is a crucial component in the combined cycle power plant, which utilises gas turbine exhaust gases to heat water into further hot steam. Research is needed to improve the heat transfer process in the LP Evaporator. One way to increase the heat transfer is by adding a Vortex Generator (VG) to the LP evaporator. The Vortex Generator itself is a vortex generator that aims to make the fluid flow from the gas turbine not only hit the tube banks in the HRSG but also between the tubes installed a Vortex Generator, which functions to make the fluid flow that was previously laminar into turbulent so that the heat transfer that occurs in LP Evaporator just got better. The analysis consists to velocity contour, temperature contour, local Nu, heat transfer (q), and pressure drop. To determine fluid flow using 2D simulation with Computational Fluid Dynamics (CFD). From the geometry type. Variations made are geometric shapes and the VG arrangement, namely rectangular common flow down, delta winglet common flow down, delta winglet common flow up, and rectangular common flow up. The heat transfer rate value is 2271.34 W, 2333.27 W, 3340.334 W, 3090.747 W. The highest heat transfer rate value occurs on the delta winglet with the common flow up arrangement, and the lowest heat transfer rate value occurs on rectangular with the common flow down arrangement.
Navigation Channel Capacity Modeling: A Case Study for Balikpapan Bay
Authors: Mustakim Achmad , Nur Hasan Iqbal , Yuliana Naning 
Published: February 2022

Abstract
Vessel traffic flow in Balikpapan Bay will increase to follow the nation’s new capital city planning development in East Kalimantan affects the demand for development on a large scale from all around Indonesia to the new area in East Kalimantan. This final project aims to determine the maximum number of vessels passing a particular channel per unit time. The discrete simulation method will use Anylogic software to determine the channel capacity with the channel length, vessel safety distance, and vessel velocity. The number of vessel arrival to Balikpapan Bay is estimated using the Forecasting Method and Moving Average Method. The results showed that the recommended channel capacity is 74 units/day or equal to 27.010 units/year with a utility rate of 80%. That maximum number of vessels entering the channel can guarantee the safety level of shipping activities and reduce queues that cause congestion and costs arising from long waiting times for channel services and the stability of port workload. Based on these conditions, Balikpapan Bay could accommodate vessel arrival during materials and heavy-duty equipment for the nation’s new capital city planning development until 2032. The total number of vessel arrival is 24.282 units and a utility rate of 72%.
Comparison of voltage harmonics in AC and DC shipboard electrical power distribution systems: A case study of 17,500 DWT tanker vessel
Authors: Budianto Firman , Kurniawan Adi , Kusuma Indra R. , Kurniawan Akhmad R. , Gumilang Ahlur R.N. 
Published: February 2022

Abstract
Recently, direct current (DC) shipboard electrical power distribution systems has begun to be looked at to replace conventional alternating current (AC) distribution systems. DC distribution systems has some technical advantages such as lower power losses and drop voltage across the distribution cables. However, there is a drawback in its high harmonics distortion due to the utilization of AC-DC rectifier in the generation side and DC-AC inverter in the load side. This study tries to investigate how much increase of voltage harmonics when a conventional AC shipboard electrical power distribution systems is replaced with equal DC systems. A 17,500 deadweight tonnage (DWT) shipboard systems is used as the case study. Both of AC and DC distribution systems are modelled with a same generation and load systems in a simulation software and the results are being compared. The comparison shows that DC distribution systems generate voltage harmonics are higher than AC distribution systems for the sample vessel.
LNG Distribution Optimization using Set Partitioning Problem Method
Authors: Adli AWS , Prastyasari FI , Handani DW , Artana KB 
Published: February 2022

Abstract
The Indonesian government’s commitment to increase the use of gas for domestic demand, by issuing the Decree of the Minister of Energy and Mineral Resources Number 13K/13/MEM/2020 concerning the Assignment of the Implementation of the Supply and Development of LNG Infrastructure and the Gasification 52 power plants in Indonesia. Therefore, a study on the supply chain design that can support the gasification process of the 52 power plants is crucial. Power plant data is imperative to identify receiving terminals which are then grouped into 8 clusters using the K-Means method. The design will use operating LNG refineries, which will then go to the hub for each cluster. Considering the feasibility factor of the receiving terminal and using the center of gravity method carries the determination of the hub. Considering the investment and operational costs form the feasible route as the most optimal by using the Set Partitioning Problem (SPP) method. The optimization considers several types of ships with six different sizes. The total investment cost required was $107,815,749.11, and the operational cost was $68,993,709.11. The results of the economic analysis indicate the distribution will reach a payback period within 10 years if gas sales use a margin of 1,75 USD.
Prediction Performance of Two Stroke Semi Free Piston Diesel Engine with Dual Piston System
Authors: Fathallah Aguk Zuhdi Muhammad , Bimatara Ian , Bakar Rosli Abu 
Published: February 2022

Abstract
The design of the semi-free piston two-stroke diesel engines has been successfully implemented. Before the engine is built, it is necessary to predict its performance. Prediction is done by using the simulation method. This method is considered the most effective because it does not fabricate the machine first. Modelling and simulation are done using application software. Simulation modelling covers all parts of the engine, namely the intake system, block, injection system, and then exhaust system. Engine performance predictions are based on speed variations as well as load variations. Validation is done with a conventional machine. The difference between the two engines lies in friction losses, where the free piston concept is to reduce friction losses. The simulation results are engine performance such as torque, power, bsfc, bmep, and combustion processes such as heat release, pressure, and ignition delay. The difference in the performance of the semi-free piston compared to a conventional engine with the same combustion chamber size. Prediction results state that the difference in performance is very significant.
Optimalization of Smart Technologies in Improving Sustainable Maritime Transportation
Authors: Priadi Antoni Arif 
Published: February 2022

Abstract
The geographical constellation of Indonesia among Asia and Australia as well as among Indian and Pasific ocean has an important role in sea transportation internationally and domestically. This paper is aimed to elaborate the advantage of geographical constellation in relation with sea transportation, to discuss the Indonesia policies on sea transportation and to challenge the smart technology for answering the challenges. The discussion began with six areas of Indonesian policies such as: competitive sea transportation, connectivity, seperti infrastructure, compliance on safety and security, law enforcement and integration in organizational management. The paper also gave example on how currently information technology applied on Inaportnet, National Logistic Ecosystem, Sitolaut and harzadous and harmful substances management system. Further research to support each of six areas on the context of smart technology need to be developed.
Efficient privacy-preserving whole-genome variant queries
Authors: Akgün Mete , Pfeifer Nico , Kohlbacher Oliver 
Published: February 2022

Abstract

Motivation
Diagnosis and treatment decisions on genomic data have become widespread as the cost of genome sequencing decreases gradually. In this context, disease–gene association studies are of great importance. However, genomic data are very sensitive when compared to other data types and contains information about individuals and their relatives. Many studies have shown that this information can be obtained from the query-response pairs on genomic databases. In this work, we propose a method that uses secure multi-party computation to query genomic databases in a privacy-protected manner. The proposed solution privately outsources genomic data from arbitrarily many sources to the two non-colluding proxies and allows genomic databases to be safely stored in semi-honest cloud environments. It provides data privacy, query privacy and output privacy by using XOR-based sharing and unlike previous solutions, it allows queries to run efficiently on hundreds of thousands of genomic data.

Results
We measure the performance of our solution with parameters similar to real-world applications. It is possible to query a genomic database with 3 000 000 variants with five genomic query predicates under 400 ms. Querying 1 048 576 genomes, each containing 1 000 000 variants, for the presence of five different query variants can be achieved approximately in 6 min with a small amount of dedicated hardware and connectivity. These execution times are in the right range to enable real-world applications in medical research and healthcare. Unlike previous studies, it is possible to query multiple databases with response times fast enough for practical application. To the best of our knowledge, this is the first solution that provides this performance for querying large-scale genomic data.

Availability and implementation
https://gitlab.com/DIFUTURE/privacy-preserving-variant-queries.

Supplementary information
Supplementary data are available at Bioinformatics online.
Different saccadic profile in bulbar versus spinal-onset amyotrophic lateral sclerosis
Authors: Zaino Domenica , Serchi Valeria , Giannini Fabio , Pucci Barbara , Veneri Giacomo , Pretegiani Elena , Rosini Francesca , Monti Lucia , Rufa Alessandra 
Published: February 2022

Abstract
Two clinical phenotypes characterize the onset of amyotrophic lateral sclerosis (ALS): the spinal variant, with symptoms beginning in the limbs, and the bulbar variant, affecting firstly speech and swallowing. The two variants show some distinct features in the histopathology, localization and prognosis, but to which extent they really differ clinically and pathologically remains to be clarified. Recent neuropathological and neuroimaging studies have suggested a broader spreading of the neurodegenerative process in ALS, extending beyond the motor areas, toward other cortical and deep grey matter regions, many of which are involved in visual processing and saccadic control. Indeed, a wide range of eye movement deficits have been reported in ALS, but they have never been used to distinguish the two ALS variants.
Since quantifying eye movements is a very sensitive and specific method for the study of brain networks, we compared different saccadic and visual search behaviours across spinal ALS patients (n = 12), bulbar ALS patients (n = 6) and healthy control subjects (n = 13), along with cognitive and MRI measures, with the aim to define more accurately the two patients subgroups and possibly clarify a different underlying neural impairment.
We found separate profiles of visually-guided saccades between spinal (short saccades) and bulbar (slow saccades) ALS, which could result from the pathologic involvement of different pathways.
We suggest an early involvement of the parieto-collicular-cerebellar network in spinal ALS and the fronto-brainstem circuit in bulbar ALS. Overall, our data confirm the diagnostic value of the eye movements analysis in ALS and add new insight on the involved neural networks.
Sex-related brain connectivity correlates of compensation in adults with autism: insights into female protection
Authors: Walsh Melissa J M , Pagni Broc , Monahan Leanna , Delaney Shanna , Smith Christopher J , Baxter Leslie , Braden B Blair 
Published: February 2022

AbstractThe male preponderance in autism spectrum disorder (ASD) led to the hypothesis that aspects of female biology are protective against ASD. Females with ASD (ASD-F) report more compensatory behaviors (i.e. “camouflaging”) to overcome ASD-related social differences, which may be a mechanism of protection. No studies have examined sex-related brain pathways supporting camouflaging in ASD-F, despite its potential to inform mechanisms underlying the ASD sex bias. We used functional connectivity (FC) to investigate “sex-atypical” and “sex-typical” FC patterns linked to camouflaging in adults with ASD and examined multimodal coherence of findings via structural connectometry. Exploratory associations with cognitive/emotional functioning examined the adaptive nature of FC patterns. We found (i) “sex-atypical” FC patterns linked to camouflaging in the hypothalamus and precuneus and (ii) “sex-typical” patterns in the right anterior cingulate and anterior parahippocampus. Higher hypothalamic FC with a limbic reward cluster also correlated with better cognitive control/emotion recognition. Structural connectometry validated FC results with consistent brain pathways/effect patterns implicated in ASD-F. In summary, “male-typical” and “female-typical” brain connectivity patterns support camouflaging in ASD-F in circuits implicated in reward, emotion, and memory retrieval. “Sex-atypical” results are consistent with fetal steroidogenic/neuroinflammatory hypotheses. However, female genetics/biology may contribute to “female-typical” patterns implicated in camouflaging.
Evolution of Imipenem-Relebactam Resistance Following Treatment of Multidrug-Resistant Pseudomonas aeruginosa Pneumonia
Authors: Shields Ryan K , Stellfox Madison E , Kline Ellen G , Samanta Palash , Van Tyne Daria 
Published: February 2022

Abstract
We report the emergence of imipenem-relebactam nonsusceptible Pseudomonas aeruginosa in 5 patients treated for nosocomial pneumonia for 10–28 days. Genome sequence analysis identified treatment-emergent mutations in MexAB-OprM and/or MexEF-OprN efflux operons that arose independently in each patient across distinct P. aeruginosa sequence types. Testing with efflux-inhibitor PAβN restored imipenem-relebactam susceptibility.
Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis
Authors: van Veldhuisen Sophie L , Gorter Thomas M , van Woerden Gijs , de Boer Rudolf A , Rienstra Michiel , Hazebroek Eric J , van Veldhuisen Dirk J 
Published: February 2022

Abstract

Aims
Obesity is a global health problem, associated with significant morbidity and mortality, often due to cardiovascular (CV) diseases. While bariatric surgery is increasingly performed in patients with obesity and reduces CV risk factors, its effect on CV disease is not established. We conducted a systematic review and meta-analysis to evaluate the effect of bariatric surgery on CV outcomes, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline.

Methods and results
PubMed and Embase were searched for literature until August 2021 which compared bariatric surgery patients to non-surgical controls. Outcomes of interest were all-cause and CV mortality, atrial fibrillation (AF), heart failure (HF), myocardial infarction, and stroke. We included 39 studies, all prospective or retrospective cohort studies, but randomized outcome trials were not available. Bariatric surgery was associated with a beneficial effect on all-cause mortality [pooled hazard ratio (HR) of 0.55; 95% confidence interval (CI) 0.49–0.62, P &lt; 0.001 vs. controls], and CV mortality (HR 0.59, 95% CI 0.47–0.73, P &lt; 0.001). In addition, bariatric surgery was also associated with a reduced incidence of HF (HR 0.50, 95% CI 0.38–0.66, P &lt; 0.001), myocardial infarction (HR 0.58, 95% CI 0.43–0.76, P &lt; 0.001), and stroke (HR 0.64, 95% CI 0.53–0.77, P &lt; 0.001), while its association with AF was not statistically significant (HR 0.82, 95% CI 0.64–1.06, P = 0.12).

Conclusion
The present systematic review and meta-analysis suggests that bariatric surgery is associated with reduced all-cause and CV mortality, and lowered incidence of several CV diseases in patients with obesity. Bariatric surgery should therefore be considered in these patients.
Impact of oral anticoagulation on the association between frailty and clinical outcomes in people with atrial fibrillation: nationwide primary care records on treatment analysis
Authors: Wilkinson Chris , Wu Jianhua , Clegg Andrew , Nadarajah Ramesh , Rockwood Kenneth , Todd Oliver , Gale Chris P 
Published: February 2022

Abstract

Aims
People with atrial fibrillation (AF) frequently live with frailty, which increases the risk of mortality and stroke. This study reports the association between oral anticoagulation (OAC) and outcomes for people with frailty, and whether there is overall net benefit from treatment in people with AF.

Methods and results
Retrospective open cohort electronic records study. Frailty was identified using the electronic frailty index. Primary care electronic health records of 89 996 adults with AF and CHA2DS2-Vasc score of ≥2 were linked with secondary care and mortality data in the Clinical Practice Research Database (CPRD) from 1 January 1998 to 30 November 2018. The primary outcome was a composite of death, stroke, systemic embolism, or major bleeding. Secondary outcomes were stroke, major bleeding, all-cause mortality, transient ischaemic attack, and falls. Of 89 996 participants, 71 256 (79.2%) were living with frailty. The prescription of OAC increased with degree of frailty. For patients not prescribed OAC, rates of the primary outcome increased alongside frailty category. Prescription of OAC was associated with a reduction in the primary outcome for each frailty category [adjusted hazard ratio, 95% confidence interval, no OAC as reference; fit: vitamin K antagonist (VKA) 0.69, 0.64–0.75, direct oral anticoagulant (DOAC) 0.42, 0.33–0.53; mild frailty: VKA 0.52, 0.50–0.54, DOAC 0.57, 0.52–0.63; moderate: VKA 0.54, 0.52–0.56, DOAC 0.57, 0.52–0.63; severe: VKA 0.48, 0.45–0.51, DOAC 0.58, 0.52–0.65], with cumulative incidence function effects greater for DOAC than VKA.

Conclusion
Frailty among people with AF is common. The OAC was associated with a reduction in the primary endpoint across all degrees of frailty.
High Stability of the Epigenome inDrosophilaInterspecific Hybrids
Authors: Bodelón Alejandra , Fablet Marie , Veber Philippe , Vieira Cristina , García Guerreiro Maria Pilar 
Published: February 2022

AbstractInterspecific hybridization is often seen as a genomic stress that may lead to new gene expression patterns and deregulation of transposable elements (TEs). The understanding of expression changes in hybrids compared with parental species is essential to disentangle their putative role in speciation processes. However, to date we ignore the detailed mechanisms involved in genomic deregulation in hybrids. We studied the ovarian transcriptome and epigenome of the Drosophila buzzatii and Drosophila koepferae species together with their F1 hybrid females. We found a trend toward underexpression of genes and TE families in hybrids. The epigenome in hybrids was highly similar to the parental epigenomes and showed intermediate histone enrichments between parental species in most cases. Differential gene expression in hybrids was often associated only with changes in H3K4me3 enrichments, whereas differential TE family expression in hybrids may be associated with changes in H3K4me3, H3K9me3, or H3K27me3 enrichments. We identified specific genes and TE families, which their differential expression in comparison with the parental species was explained by their differential chromatin mark combination enrichment. Finally, cis–trans compensatory regulation could also contribute in some way to the hybrid deregulation. This work provides the first study of histone content in Drosophila interspecific hybrids and their effect on gene and TE expression deregulation.
Spectral element numerical simulation of the 2009 L’Aquila earthquake on a detailed reconstructed domain
Authors: Di Michele F , May J , Pera D , Kastelic V , Carafa M , Smerzini C , Mazzieri I , Rubino B , Antonietti P F , Quarteroni A , Aloisio R , Marcati P 
Published: February 2022

SUMMARY
In this paper, we simulate the earthquake that hit the city of L’Aquila on 2009 April 6 using SPEED (SPectral Elements in Elastodynamics with Discontinuous Galerkin), an open-source code able to simulate the propagation of seismic waves in complex 3-D domains. Our model includes an accurate 3-D reconstruction of the Quaternary deposits, according to the most up-to-date data obtained from the Microzonation studies in Central Italy and a detailed model of the topography incorporated using a newly developed tool. The sensitivity of our results with respect to different kinematic seismic sources is investigated. The results obtained are in good agreement with the recordings at the available seismic stations at epicentral distances within a range of 20 km. Finally, a blind source prediction scenario application shows that a reasonably good agreement between simulations and recordings can be obtained by simulating stochastic rupture realizations with basic input data. These results, although limited to nine simulated scenarios, demonstrate that it is possible to obtain a satisfactory reconstruction of a ground shaking scenario employing a stochastic source constrained on a limited amount of ex-ante information. A similar approach can be used to model future and past earthquakes for which little or no information is typically available, with potential relevant implications for seismic risk assessment.