bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile and green fabrication of copper‐based magnetically recoverable yolk–shell nanocatalysts with high catalytic performance for nitroaromatic reduction
Authors: Maleki Mohammad Hassan , Dinari Mohammad , Arameshian Saed 
Published: December 2022

A simple method was reported to achieve a green yolk–shell Fe3O4@SiO2@CuO nanocatalysts (YS‐Fe3O4@SiO2@CuO). Glucose (G) and lactose (L), as a grafting agent, were applied for decorating CuO on the magnetic nanoparticles surface and then using calcination method, yolk–shell structure was obtained. Characterization of nanocatalysts was carried out using inductively coupled plasma–optical emission spectrometry (ICP‐OES), field emission scanning electron microscopy (FE‐SEM), transmission electron microscopy (TEM), energy‐dispersive X‐ray (EDX)‐Mapping, thermogravimetric analysis (TGA), X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FT‐IR), X‐ray photoelectron spectroscopy (XPS), Brunauer, Emmett, and Teller (BET), and vibrating sample magnetometer (VSM) analyses and the results confirmed the successful synthesis of these catalysis. The activity of the nanocatalysts were studied to reduce nitroaromatic compounds monitoring by UV–Vis spectra. In the model reaction, 4‐nitrophenol was reduced using YS‐Fe3O4@SiO2@CuO(G) and YS‐Fe3O4@SiO2@CuO(L), with the activity factors (k′) of 3218 and 2023 s−1 g−1, and rate constants (Kapp) of 0.56 and 1.19 min−1, respectively. The advantages of prepared nanocatalysts were good stability and high conversion. The magnetic property of nanocatalysts makes them easy to recover in multiple cycles.
Strong and high void fraction PP/CNS nanocomposite foams fabricated by core‐back foam injection molding
Authors: Wang Long , Wu Minghui , Ren Qian , Weng Zhengsheng , Li Wanwan , Zhu Xiuyu , Zheng Wenge , Yi Xiaosu 
Published: December 2022

AbstractPolypropylene/carbon nanostructure (PP/CNS) nanocomposite foams with a void fraction as high as 78% were successfully prepared by foam injection molding (FIM) with core‐back operation. Rheological curves and differential scanning calorimetry results showed that the added CNS significantly improved the melt strength and accelerated the crystallization process of PP, respectively. A high mold temperature was applied to overcome the adverse effect of CNS, which had a high thermal conductivity and went against the preparation of high void fraction (VF) products. Thus, adding CNS could dramatically increase cell density by three orders of magnitude. With a CNS loading of 5 wt%, the PP/CNS nanocomposite foam with a cell size of about 60 μm, cell density over 107 cells/cm3, and a void fraction of 78% was obtained. More interestingly, the specific flexural modulus of the PP/CNS composite foam with 50% void‐fraction was increased by 37% relative to the neat solid injection‐molded PP. PP/CNS composite foams with adjustable cell structure and good mechanical properties show great potential for electromagnetic interference (EMI) shielding and sensors applications.
An immunometabolic patch facilitates mesenchymal stromal/stem cell therapy for myocardial infarction through a macrophage‐dependent mechanism
Authors: Xiao Weizhang , Chen Ming , Zhou Wenjing , Ding Liang , Yang Ziying , Shao Lianbo , Li Jingjing , Chen Weiqian , Shen Zhenya 
Published: December 2022

AbstractMesenchymal stromal/stem cells (MSCs) have emerged as a promising approach against myocardial infarction. Due to hostile hyperinflammation, however, poor retention of transplanted cells seriously impedes their clinical applications. Proinflammatory M1 macrophages, which rely on glycolysis as their main energy source, aggravate hyperinflammatory response and cardiac injury in ischemic region. Here, we showed that the administration of an inhibitor of glycolysis, 2‐deoxy‐d‐glucose (2‐DG), blocked the hyperinflammatory response within the ischemic myocardium and subsequently extended effective retention of transplanted MSCs. Mechanistically, 2‐DG blocked the proinflammatory polarization of macrophages and suppressed the production of inflammatory cytokines. Selective macrophage depletion abrogated this curative effect. Finally, to avoid potential organ toxicity caused by systemic inhibition of glycolysis, we developed a novel chitosan/gelatin‐based 2‐DG patch that directly adhered to the infarcted region and facilitated MSC‐mediated cardiac healing with undetectable side effects. This study pioneered the application of an immunometabolic patch in MSC‐based therapy and provided insights into the therapeutic mechanism and advantages of this innovative biomaterial.
Real‐time online monitoring of insect cell proliferation and baculovirus infection using digital differential holographic microscopy and machine learning
Authors: Altenburg Jort J. , Klaverdijk Maarten , Cabosart Damien , Desmecht Laurent , Brunekreeft‐Terlouw Sonja S. , Both Joshua , Tegelbeckers Vivian I. P. , Willekens Marieke L. P. M. , van Oosten Linda , Hick Tessy A. H. , van der Aalst Tom M. H. , Pijlman Gorben P. , van Oers Monique M. , Wijffels René H. , Martens Dirk E. 
Published: December 2022

AbstractReal‐time, detailed online information on cell cultures is essential for understanding modern biopharmaceutical production processes. The determination of key parameters, such as cell density and viability, is usually based on the offline sampling of bioreactors. Gathering offline samples is invasive, has a low time resolution, and risks altering or contaminating the production process. In contrast, measuring process parameters online provides more safety for the process, has a high time resolution, and thus can aid in timely process control actions. We used online double differential digital holographic microscopy (D3HM) and machine learning to perform non‐invasive online cell concentration and viability monitoring of insect cell cultures in bioreactors. The performance of D3HM and the machine learning model was tested for a selected variety of baculovirus constructs, products, and multiplicities of infection (MOI). The results show that with online holographic microscopy insect cell proliferation and baculovirus infection can be monitored effectively in real time with high resolution for a broad range of process parameters and baculovirus constructs. The high‐resolution data generated by D3HM showed the exact moment of peak cell densities and temporary events caused by feeding. Furthermore, D3HM allowed us to obtain information on the state of the cell culture at the individual cell level. Combining this detailed, real‐time information about cell cultures with methodical machine learning models can increase process understanding, aid in decision‐making, and allow for timely process control actions during bioreactor production of recombinant proteins.
Efficacy and safety of endoscopic “calabash” ligation and resection for small gastric stromal tumors originating from the muscularis propria
Authors: Peng Min‐Si , Zeng Hao‐Tian , Zhang Zhu‐Liang , Chen Ze‐Ming , Long Ting , Wang Li‐Sheng , Xu Zheng‐Lei 
Published: December 2022

AbstractAimWe compared endoscopic “calabash” ligation and resection (ECLR) and endoscopic submucosal excision (ESE) in treating endophytic gastric stromal tumors (GSTs) ≤15 mm in diameter originating from the muscularis propria.MethodsWe performed a retrospective study and included patients who visited our hospital for removal of small endophytic GSTs (diameter ≤ 15 mm) confirmed by postoperative pathological reports between February 2019 and December 2020. Patients were assigned to the study (received ECLR) or control (accepted ESE) groups, and their medical records were reviewed. Age, sex, GST size, resection outcomes, procedure measurements, lengths of hospital stays, medical expenses, intraoperative and postoperative complications, and follow‐up outcomes were documented and compared between the two groups. Propensity score matching was used to avoid retrospective biases.ResultsA total of 277 patients were included in the analysis, with 135 in the study group and 142 in the control group. After propensity score matching, 119 cases in each group were finally included in the study. Compared to the control group, the study group had significantly shorter procedure durations and lengths of hospital stays, as well as reduced medical expenses. Compared to the control group, the study group also had significantly lower incidence rates of intraoperative stomach perforation, postoperative intraperitoneal infection, and postoperative electrocoagulation syndrome, as well as a lower intensity of postoperative pain. There were no significant differences in the other measurements between the two groups.ConclusionECLR is an effective and safe procedure for treating patients with endophytic GSTs ≤15 mm in diameter originating from the muscularis propria.
An interview study exploring clients' experiences of receiving therapeutic support for family estrangement in the UK
Authors: Blake Lucy , Rouncefield‐Swales Alison , Bland Becca , Carter Bernie 
Published: December 2022

AbstractMany people experience estrangement from a family member, which is broadly understood to refer to negative relationships that are characterised by little or no contact. However, little is known about how people cope with family estrangement. To address this gap, interviews were conducted with 46 participants who identified as being estranged from a parent/sibling and/or child and having sought therapeutic support for this experience. The participants were recruited from a UK‐based charity that supports individuals experiencing family estrangement. The participants had a range of experiences of therapeutic support, with most (N = 31, 67%) having paid for private therapy. The data were analysed using thematic analysis, and three themes were generated: (1) finding the missing qualities in estranged family relationships: warmth, validation and safety; (2) speaking the unspoken: addressing the causes and consequences of estrangement; and (3) learning relational skills: improving the relationship with oneself and with others. When the causes of estrangement were addressed in the context of a safe therapeutic relationship, participants learned strategies to improve the relationships they had both with themselves and with others. When participants experienced a cold or unresponsive therapeutic relationship, and the causes and consequences of estrangement were not adequately addressed or understood, counselling was experienced as unhelpful. Individuals who seek therapeutic support for family estrangement have specific needs. Training around these needs and the causes and consequences of estrangement could be beneficial to helping professionals and the clients with whom they work.
Hydroalcoholic Extract of Rabbiteye Blueberry (Vaccinium ashei) Leaves Mitigates Unpredictable Chronic Mild Stress Model Inducing Depressive‐Like Behavior in Rats
Authors: Schneider Cezarotto Verciane , Mota Ferreira Luana , Pizzi Dal'Pupo Rafaela , dos Santos Adriel , Freitas Santos Karen , Blanco Linares Carlos Eduardo , Stein Ana Cristina , Marcondes Sari Marcel Henrique , Cruz Letícia 
Published: December 2022

AbstractSeveral studies reported that rabbiteye blueberry (Vaccinium ashei Reade) leaves present promising biological properties. To the best of our knowledge, no study investigated the possible application of their hydroalcoholic extract for treating mood disorders. Herein, we evaluated if the hydroalcoholic extract of rabbiteye blueberry (Vaccinium ashei Reade) leaves (HEV) promotes an antidepressant‐like effect in rodents using chronic experimental approaches. The effect of repeated administration of HEV (50 mg/kg, p.o.) on the immobility time was assessed in the forced swimming test (FST) in an unpredictable chronic mild stress (UCMS) model. Repeated treatment with HEV reversed the depressive‐like behavior induced by UCMS by reducing the immobility time. Besides, the exposure to HEV caused no changes in relative organ weights in rats submitted to UCMS. The results indicated that HEV administration presented antidepressant‐like action devoid of toxic effects. Thus, it is possible to suggest its potential as a safe and accessible therapeutic tool in the management of depression and other related mood disorders.
Tropolone‐Conjugated DNA: A Fluorescent Thymidine Analogue Exhibits Solvatochromism, Enzymatic Incorporation into DNA and HeLa Cell Internalization
Authors: Meher Sagarika , Gade Chandrasekhar Reddy , Sharma Nagendra K. 
Published: December 2022

AbstractTropolone is a non‐benzenoid aromatic scaffold with unique photophysical and metal‐chelating properties. Recently, it has been conjugated with DNA, and the photophysical properties of this conjugate have been explored. Tropolonyl‐deoxyuridine (tr‐dU) is a synthetic fluorescent DNA nucleoside analogue that exhibits pH‐dependent emissions. However, its solvent‐dependent fluorescence properties are unexplored owing to its poor solubility in most organic solvents. It would be interesting to incorporate it into DNA primer enzymatically. This report describes the solvent‐dependent fluorescence properties of the silyl‐derivative, and enzymatic incorporation of its triphosphate analogue. For practical use, its cell‐internalization and cytotoxicity are also explored. tr‐dU nucleoside was found to be a potential analogue to design DNA probes and can be explored for various therapeutic applications in the future.
Lactate: a pearl dropped in the ocean—an overlooked signal molecule in physiology and pathology
Authors: Wu Yue , Ma Wanqi , Liu Wei , Zhang Shuping 
Published: December 2022

AbstractLactate, once recognized as a wasty product from anaerobic glycolysis, is proved to be a pivotal signal molecule. Lactate accumulation occurs in diverse physiological and pathological settings due to the imbalance between lactate production and clearance. Under the condition with drastic changes in local microenvironment, such as tumorigenesis, inflammation, and microbial infection, the glycolysis turns to be active in surrounding cells leading to increased lactate release. Meanwhile, lactate can be utilized by these cells as an energy substrate and acts as a signal molecule to regulate cell functions through receptor‐dependent or independent pathways. In this review, we tended to tease out the contribution of lactate in tumor progression and immunomodulation. And we also discussed the accessory role of lactate, beyond as the energy source only, in the growth of invading pathogens.
“Reverse Spider View” for left stem coronary artery angiographic evaluation
Authors: Rigatelli Gianluca , Gianese Filippo , Zuin Marco , Rodino’ Giulio , Marchese Giuseppe , Pasquetto Giampaolo 
Published: December 2022

AbstractAmong the angiographic views used to evaluate left coronary system, the so‐called “spider view” represents one of the most iconic, in particular for its ability to evaluate the Left Main stem (LM) and/or to guide percutaneous coronary interventions (PCIs) on LM bifurcation disease. Unfortunately, the use of such view is graved by a high X‐ray exposure for both the operator and the patient. To overcome these limitations, we described an alternative coronary angiographic view, called “reverse spider” which is able to give more information about LM body and bifurcation disease with less X‐ray exposure for the operator.
Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis
Authors: Lelong Margaux , Raoul Jean‐Luc , Touchefeu Yann , Berthelot Jean‐Marie , Arnolfo Paul , Matysiak‐Budnik Tamara , Senellart Hélène 
Published: December 2022

AbstractThis 38‐year‐old man has a familial BRCA2 mutation. He presented with skin erythema, polyarthritis, dactylitis, and febrile erythema nodosum; a biopsy of a liver metastase revealed acinar cell carcinoma of the pancreas. After FOLFIRINOX, olaparib was initiated, and 24 months after, the patient was PS 0 and asymptomatic.
Hemophagocytic Lymphohistiocytosis secondary to Rickettsial infection: A case report
Authors: Sharma Shriya , Adhikari Aakriti , Ghimire Nirmal , Mainali Gaurab , Yadav Sumit Kumar , Pudasaini Prasamsa , Neupane Shashank 
Published: December 2022

AbstractHemophagocytic Lymphohistiocytosis (HLH) is a rare life‐threatening condition characterized by widespread activation of the immune system leading to tissue damage all over the body. It is divided into primary HLH due to inborn error in lymphocytes, T cells, and macrophages and secondary HLH which is mostly due to infections, systemic connective tissue diseases, and lymphoid malignancies. Here, we report a 34‐year‐old man with a history of high‐grade fever, chills, and rigor, eschar, splenomegaly with the laboratory findings of thrombocytopenia, hypochromic RBCs with anisocytosis and basophilic stippling, elevated transaminases, and a positive Weil Felix test along with positive PCR results for Orientia tsutsugamushi and the presence of IgG and IgM antibodies. A detailed workup was done to rule out other etiology for fever. Diagnosis of HLH secondary to Rickettsia infection was made with a thorough history, clinical evaluation, and a variety of investigations. The patient was treated with Doxycycline, Ciprofloxacin, Etoposide, and Dexamethasone but unfortunately, the patient died during treatment due to multiorgan failure. Patients with scrub typhus typically respond well to therapy; therefore, early detection and antibiotic treatment can help avoid serious complications. Scrub typhus with the hemophagocytic syndrome can result in DIC and multiorgan failure. Despite its rarity, scrub typhus may be lethal; as a result, practitioners must be aware of the necessity of detecting and treating suspected cases as soon as possible. We learned that a systematic diagnostic approach, use of diagnostic criteria, and prompt treatment are very crucial in this disease.
Development of Anion Exchange Membrane Water Electrolysis and the Associated Challenges: A Review
Authors: Hua Daxing , Huang Jinzhen , Fabbri Emiliana , Rafique Moniba , Song Bo 
Published: December 2022

AbstractWater electrolysis technologies for hydrogen production from renewable energy play an important role in a carbon‐free energy scenario. Anion exchange membrane water electrolysis (AEMWE) is one of the most cost‐effective and promising water electrolysis technologies due to the application of efficient, non‐noble metal electrocatalysts and the fast development of anion exchange membranes (AEMs). In this review, the most recent and significant achievements in AEMWE were summarized, including the progress in enhancing AEM conductivity and understanding their degradation mechanism, and the hot topics concerning the electrocatalyst design. The key factors that affect AEMWE performance were pointed out, further challenges and opportunities have also been discussed. The expectations for future development of AEMWE devices were also addressed. Finally, this review provided valuable guidelines for developing highly active and durable electrocatalysts and advancing the fabrication of AEMWE devices.
A Water‐Free ITIES: Ionic Liquid/Oil Interface for Base Metal Nanostructure Formation – Zn Case
Authors: Nishi Naoya , Kuroyama Yohei , Yoshida Naohiro , Yokoyama Yuko , Sakka Tetsuo 
Published: December 2022

AbstractReductive metal deposition at the interface between two immiscible electrolyte solutions (ITIES), the oil/water interface, is an attractive methodology to produce metal nanostructures. However, the metals that can be deposited are limited to noble metals; otherwise, water molecules are reduced. Herein, a method to overcome this limitation by utilizing a novel water‐free ITIES between a hydrophilic ionic liquid and oil was introduced. As proof‐of‐concept experiments, the reductive deposition of zinc, a base metal with a standard redox potential more negative than that of water, was successfully realized at the ionic liquid/oil interface. The morphology of the zinc nanostructures was investigated, and the reaction mechanism was discussed, in which the electron transfer and ion transfer reactions across the interface simultaneously occurred to maintain the electroneutrality of the liquids.
Highly Dispersed In‐Situ Grown Bi2O3 Nanosheets on Ti3C2Tx MXene for Selective Electroreduction of Nitrate to Ammonia
Authors: Zhang Hao‐Yu , Li Lan‐Xin , Sun Wu‐Ji , He Jing‐Hui , Xu Qing‐Feng , Lu Jian‐Mei 
Published: December 2022

AbstractNitrate, a common pollutant in water, can be used as a nitrogen source for electrocatalytic ammonia production. Bismuth oxide (Bi2O3) is a promising electrocatalyst because of earth‐abundance and high hydrogen overpotential. However, it also has the disadvantages of easy agglomeration and poor charge transfer. This study demonstrated that the high dispersion of Bi2O3 nanosheets can be achieved through in‐situ growth on Ti3C2Tx MXene nanosheets that improved the efficiency of charge transmission, and thus improving the electrocatalytic ammonia production performance. A NH3 yield rate of ∼7.00 mg h−1 cm−2 with faradic efficiency of 91.1 % could be achieved on 11 % Bi2O3/MXene. Density functional theory (DFT) calculations, electrochemical active surface area (ECSA) and electrochemical impedance spectroscopy (EIS) proved that the excellent ammonia production performance came from the fact that bismuth oxide itself could inhibit hydrogen evolution, and in situ growth on MXene enabled high active site exposure and enhanced charge transfer capacity.
Anion Exchange Membrane Water Electrolysis Based on Nickel Ferrite Catalysts
Authors: Caprì Angela , Gatto Irene , Lo Vecchio Carmelo , Trocino Stefano , Carbone Alessandra , Baglio Vincenzo 
Published: December 2022

AbstractA nickel ferrite was prepared by a liquid‐phase method and used as an oxygen evolution catalyst in an anion exchange membrane electrolyser. A complete physicochemical characterization of the catalyst was performed through X‐ray diffraction (XRD), Transmission electron microscopy (TEM) and X‐ray photoelectron spectroscopy (XPS). Then, the nickel ferrite was deposited by spray coating technique onto a Fumasep® FAA3‐50 anion‐exchange membrane to realize a catalyst‐coated membrane (CCM), and tested in a 5 cm2 single cell setup in the so‐called zero‐gap configuration. At 60 °C and 2.2 V, a current density of 3 A/cm2 was reached, which is higher than that obtained with NiO and IrO2 commercial catalysts. Moreover, a chronoamperometric test of 120 h highlighted the good stability of the synthesized catalyst.
Lithium and Cobalt Recovery from Lithium‐Ion Battery Waste via Functional Ionic Liquid Extraction for Effective Battery Recycling
Authors: Morina Riccardo , Merli Daniele , Mustarelli Piercarlo , Ferrara Chiara 
Published: December 2022

AbstractSustainable management of spent lithium‐ion batteries, LIBs, is an urgent and critical challenge due to the number of such devices reaching the end‐of‐life. Recycling can offer a path for the recovery of valuable raw materials such as lithium and cobalt, whose supply is critical. Thus, it is mandatory to develop efficient ways for the selective recovery of Li and Co from the cathode degradation processes. In this study the most updated organic acids‐based processes for the degradation of LiCoO2, the most common LIBs cathode, is explored to obtain a leached solution containing Li and Co. The possibility to exploit the 3‐methyl‐1‐octylimidazolium thenoyltrifluoroacetone, Omim‐TTA, ionic liquid was demonstrated to efficiently separate Li and Co. In particular it was possible to recover >70 % of Li and separate it from Co using this ionic liquid, independently from the organic acid used for the leaching procedure and adding EDTA to the aqueous phase. The quantification was carried out through ICP analysis; the recovering of the unaltered ionic liquid was also demonstrated, to further increase the global sustainability of the process.