bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Framework for Manufacturing System Reconfiguration Based on Artificial Intelligence and Digital Twin
Authors: Mo Fan , Chaplin Jack C. , Sanderson David , Rehman Hamood Ur , Monetti Fabio Marco , Maffei Antonio , Ratchev Svetan 
Published: October 2022

AbstractThe application of digital twins and artificial intelligence to manufacturing has shown potential in improving system resilience, responsiveness, and productivity. Traditional digital twin approaches are generally applied to single, static systems to enhance a specific process. This paper proposes a framework that applies digital twins and artificial intelligence to manufacturing system reconfiguration, i.e., the layout, process parameters, and operation time of multiple assets, to enable system decision making based on varying demands from the customer or market. A digital twin environment has been developed to simulate the manufacturing process with multiple industrial robots performing various tasks. A data pipeline is built in the digital twin with an API (application programming interface) to enable the integration of artificial intelligence. Artificial intelligence methods are used to optimise the digital twin environment and improve system decision-making. Finally, a multi-agent program approach shows the communication and negotiation status between different agents to determine the optimal configuration for a manufacturing system to solve varying problems. Compared with previous research, this framework combines distributed intelligence, artificial intelligence for decision making, and production line optimisation that can be widely applied in modern reactive manufacturing applications.
Automating the Generation of MBD-Driven Assembly Work Instruction Documentation for Aircraft Components
Authors: Papadaki Aikaterini R. , Bacharoudis Konstantinos , Bainbridge David , Burbage Nick , Turner Alison , Sanderson David , Popov Atanas A. , Ratchev Svetan M. 
Published: October 2022

AbstractThe classical approach to the creation of assembly work instructions for high value, complex products is time-consuming and prone to error. It requires a process engineer to write the work instructions step-by-step and manually insert specific technical information, using an encompassing document of manufacturing parameters or life cycle management software. The latter offers synchronisation to design changes through updateable parameters, however major design modifications still require significant manual work to modify the text contents and structure of the work instructions. This leaves the work instruction documentation vulnerable to human error, as well as making the process time-consuming to fully synchronise. A methodology was therefore developed to resolve these issues, utilising JavaScript and VBA for Office to create a simple interface for rapid content generation for work instructions including text, MBD extracted parameters, images and formatting. The overall methodology speeds up the creation of assembly work instructions and reduces errors by implementing automatic insertion of parameters from an MBD model. The implementation and effectiveness of the suggested approach is demonstrated on a case study for the assembly of the joined wing configuration of the RACER helicopter, the latest generation of compound helicopters of Airbus Helicopter.
A first order description of a nonlinear SPDE in the spirit of rough paths
Authors: Kunick Florian 
Published: October 2022

AbstractWe consider a nonlinear stochastic partial differential equation (SPDE) in divergence form where the forcing term is a Gaussian noise, that is white in time and colored in space such that the gradient of the solution is Hölder-continuous, but not differentiable. Then, we prove a generalized Taylor expansion of the difference between the solution to the SPDE and the solution to its linearization around a fixed basepoint. The result is reminiscent of the theory of (controlled) rough paths and agrees with the general observation, that, in settings with a rough driver, subtracting the solution to the linearized equation yields a more regular object.
Genetic variation of glycophorins and infectious disease
Authors: Hollox Edward J. , Louzada Sandra 
Published: October 2022

Abstract
Glycophorins are transmembrane proteins of red blood cells (RBCs), heavily glycosylated on their external-facing surface. In humans, there are four glycophorin proteins, glycophorins A, B, C and D. Glycophorins A and B are encoded by two similar genes GYPA and GYPB, and glycophorin C and glycophorin D are encoded by a single gene, GYPC. The exact function of glycophorins remains unclear. However, given their abundance on the surface of RBCs, it is likely that they serve as a substrate for glycosylation, giving the RBC a negatively charged, complex glycan “coat”. GYPB and GYPE (a closely related pseudogene) were generated from GYPA by two duplication events involving a 120-kb genomic segment between 10 and 15 million years ago. Non-allelic homologous recombination between these 120-kb repeats generates a variety of duplication alleles and deletion alleles, which have been systematically catalogued from genomic sequence data. One allele, called DUP4, encodes the Dantu NE blood type and is strongly protective against malaria as it alters the surface tension of the RBC membrane. Glycophorins interact with other infectious pathogens, including viruses, as well as the malarial parasite Plasmodium falciparum, but the role of glycophorin variation in mediating the effects of these pathogens remains underexplored.
Is There Any Reliable Predictor of Functional Recovery Following Post‐thyroidectomy Vocal Fold Paralysis?
Authors: Revelli Luca , Gallucci Pierpaolo , Marchese Maria Raffaella , Voloudakis Nikolaos , Di Lorenzo Sofia , Montuori Claudio , D'Alatri Lucia , Pennestri Francesco , De Crea Carmela , Raffaelli Marco 
Published: October 2022

AbstractBackgroundPredicting definitive outcomes of post‐thyroidectomy vocal fold paralysis (VFP) is challenging. We aimed to identify reliable predictors based on intraoperative neuromonitoring (IONM) and flexible fiberoptic laryngostroboscopy (FFL) findings.MethodsAmong 1172 thyroid operations performed from April to December 2021, all patients who exhibited vocal fold paralysis (VFP) at post‐operative laryngoscopy were included. IONM data, including type of loss of signal (LOS), were collected. Patients underwent FFL, with arytenoid motility assessment, at 15, 45 and 120 days post‐operatively. Patients were divided into two groups: those who recovered vocal fold motility (VFM) by the 120th post‐operative day (recovery group) and those who did not (non‐recovery group).ResultsFifty‐nine VFP cases (5.0% of total patients) met the inclusion criteria. Eight patients were lost at follow‐up and were excluded. Overall, 9 patients were included in the non‐recovery group (0.8% of total patients) and 42 in the recovery group. Among various predictive factors, only arytenoid fixation (AF) at the 15th post‐operative day and Type I LOS were significant predictors for no VFM recovery (p = 0.007, RR = 9.739, CI:1.3–72.3 and p = 0.001, RR = 9.25, CI:2.2–39.3 for AF and Type I injury, respectively). The combination of type of LOS and arytenoid motility at the 15th post‐op day yielded satisfactory predictive values for the progression of transient VFP to permanent.ConclusionsArytenoid motility at the 15th post‐op day and type II LOS are associated with recovery of VFM. Type of LOS and FFL could be included in the follow‐up protocols of patients with VFP to reliably predict clinical outcomes.
Evaluation der Aufklärungsbroschüre Normal? Was ist das schon! zu psychischen Störungen und Psychotherapie für Jugendliche
Authors: Pfeiffer Simone , Kircher Andrea , Schlatt Lisa , In-Albon Tina 
Published: October 2022

Zusammenfassung
Hintergrund
Fehlendes Wissen über psychische Störungen und Psychotherapie sowie die Angst vor Stigmatisierung stellen zwei der meistgenannten Hemmschwellen zur Aufnahme einer Psychotherapie unter Jugendlichen dar.

Ziel der Arbeit
Evaluation der Aufklärungsbroschüre Normal? Was ist das schon! zu Psychotherapie und psychischen Störungen für Jugendliche und Psychotherapeut:innen.

Methode
Die Stichprobe bestand aus 190 Teilnehmer:innen im Alter zwischen 15 und 21 Jahren (M = 18,2 Jahre, SD ± 1,81 Jahre, 80 % weiblich). Zu 3 Messzeitpunkten (prä, post, Vier-Wochen-Follow-up) wurden Wissen, Stigma und die antizipierte Bereitschaft zur Aufnahme einer Psychotherapie sowie die Akzeptanz der Broschüre erfasst. Die Akzeptanz wurde zusätzlich von 30 Psychotherapeut:innen erhoben.

Ergebnisse
Jugendliche zeigten nach dem Lesen der Broschüre im Vergleich zur Prämessung einen signifikanten Wissenszuwachs bezüglich Psychotherapie und psychischen Störungen mit einem starken Effekt in der Post- (d = 1,32) und in der Follow-up-Erhebung (d = 1,13). Die Bereitschaft zur Aufnahme einer Psychotherapie im Fall von psychischen Problemen stieg zum Postzeitpunkt (d = 0,58) und blieb in der Follow-up-Erhebung stabil, wenn auch mit kleinem Effekt (d = 0,33). Stigmabewusstheit (d = 0,38) und -anwendung (d = 0,42) reduzierten sich zum Postzeitpunkt jeweils mit einem kleinen Effekt, jedoch blieb die Reduktion zum Follow-up-Zeitpunkt nicht stabil. Die Akzeptanzwerte bei Jugendlichen und Expert:innen waren überwiegend hoch.

Diskussion
Die Studienergebnisse zeigen die Eignung dieser Aufklärungsbroschüre, Hemmschwellen zur Aufnahme einer Psychotherapie mithilfe der Wissensvermittlung zu Psychotherapie und psychischen Störungen abzubauen. Ein nachhaltiger Abbau von stigmatisierenden Einstellungen gegenüber Psychotherapie zeigte sich nicht. Die hohe Akzeptanz spricht für ein gutes Disseminationspotenzial.
Cross-domain fusion in smart seafloor sensor networks
Authors: Zainab Tayyaba , Karstens Jens , Landsiedel Olaf 
Published: October 2022

AbstractMany of the socio-economic and environmental challenges of the 21st century like the growing energy and food demand, rising sea levels and temperatures put stress on marine ecosystems and coastal populations. This requires a significant strengthening of our monitoring capacities for processes in the water column, at the seafloor and in the subsurface. However, present-day seafloor instruments and the required infrastructure to operate these are expensive and inaccessible. We envision a future Internet of Underwater Things, composed of small and cheap but intelligent underwater nodes. Each node will be equipped with sensing, communication, and computing capabilities. Building on distributed event detection and cross-domain data fusion, such an Internet of Underwater Things will enable new applications. In this paper, we argue that to make this vision a reality, we need new methodologies for resource-efficient and distributed cross-domain data fusion. Resource-efficient, distributed neural networks will serve as data-analytics pipelines to derive highly aggregated patterns of interest from raw data. These will serve as (1) a common base in time and space for fusion of heterogeneous data, and (2) be sufficiently small to be transmitted efficiently in resource-constrained settings.
High Salinity Stimulates the Adaptive Response to Potassium Deficiency Through the Antioxidant and the NADPH-Generating Systems in the Roots and Leaves of the Halophyte Cakile maritima
Authors: Houmani Hayet , Palma José M. , Corpas Francisco J. 
Published: October 2022

AbstractSalinity is one of the most constraining environmental factors that limits plant growth and productivity because it disturbs mineral nutrition by triggering interactions at the interface soil roots. It implies a notable competition between sodium (Na+) and potassium (K+), with this last mineral being a key nutrient for plants. Using the halophyte Cakile maritima as a model plant grown in hydroponic conditions, this study was aimed to analyze how the simultaneous stressful conditions of high salinity (400 mM NaCl) and K+ deficiency (0 mM) for 15 days affect plant growth, ion balance, and antioxidant and NADPH-generating systems. Among the parameters analyzed, the most remarkable changes were observed in leaves, with drastic increases in the Na+/K+, Na+/Ca2+ and Na+/Mg2+ ratios, an enhanced accumulation of anthocyanins, and the induction of 3 new copper/zinc superoxide dismutase (CuZnSOD) isozymes in plants simultaneously exposed to both stresses. Taken together, the data revealed that the combination of both, high salinity and K+ deficiency, caused oxidative stress and modulated the whole antioxidative response of C. maritima in leaves and roots. Besides the differential response underwent by both organs, considering the different parameters analyzed under these stressful conditions, the most notable traits were that the effect of both stresses seems to be not additive and that salinity appears to improve C. maritima response to K+, a behavior not manifested in glycophyte species. Taken together our data support that, under extreme conditions that lead to an excess of ROS production, the induction of several CuZn-SODs in C. maritima may be one of the most outstanding strategies for the adaptation of this plant species to survive.
Hormone Changes in Tolerant and Susceptible Grapevine Leaves Under Powdery Mildew Infection
Authors: Amaro Rute , Diniz Inês , Santos Helena , Pimentel Diana , Rego Cecília , Mithöfer Axel , Fortes Ana Margarida 
Published: October 2022

AbstractThe biotrophic fungus Erysiphe necator causes powdery mildew (PM) in grapevine. Phytohormones are major modulators of defensive responses in plants but the analysis of the hormonome associated with grapevine tolerance and susceptibility against this pathogen has not been elucidated. In this study, changes in hormonal profiling were compared between a tolerant (Vitis rupestris × riparia cv. 101-14 Millardet et de Grasset) and a susceptible (Vitis vinifera cv. Aragonêz) species upon E. necator infection. Control and PM-infected leaves were collected at 0, 6, 24, 96 h post-infection (hpi), and analysed through LC-MS/MS. The results showed a distinct constitutive hormonome between tolerant and susceptible species. Constitutive high levels of salicylic acid (SA) and indole-3- acetic acid together with additional fast induction of SA within the first 6 hpi as well as constitutive low levels of jasmonates and abscisic acid may enable a faster and more efficient response towards the PM. The balance among the different phytohormones seems to be species-specific and fundamental in providing tolerance or susceptibility. These insights may be used to develop strategies for conventional breeding and/or editing of genes involved in hormonal metabolism aiming at providing a durable resistance in grapevine against E. necator.
Exponential Integrators for Second-Order in Time Partial Differential Equations
Authors: Phan Duy , Ostermann Alexander 
Published: October 2022

AbstractTwo types of second-order in time partial differential equations, namely semilinear wave equations and semilinear beam equations are considered. To solve these equations with exponential integrators, we present an approach to compute efficiently the action of the matrix exponential as well as those of related matrix functions. Various numerical simulations are presented that illustrate this approach.
Wie kommt Inklusion in die Schulen? Einstellung zur Inklusion als Prädiktor der inklusionsbezogenen Fortbildungsmotivation von Lehrkräften
Authors: Wächter Tobias , Gorges Julia 
Published: October 2022

ZusammenfassungFortbildungen zur inklusionsbezogenen Kompetenz- und Organisationsentwicklung an Schulen sind zentrale Erfolgsfaktoren für die Umsetzung der UN-Behindertenrechtskonvention in Deutschland. Eine positive Einstellung zu schulischer Inklusion seitens der Lehrkräfte sollte eine zentrale Rolle für die engagierte Teilnahme daran spielen. Die vorliegende Studie untersucht die Rolle von Einstellung zu Inklusion für die Fortbildungsmotivation von Lehrkräften (N = 166) mit Blick auf eine bevorstehende Fortbildung zur Kooperation an inklusiven Sekundar- und Gesamtschulen. Die Ergebnisse mehrebenenanalytischer Regressionsmodelle zeigen, dass Einstellung zu Inklusion die fortbildungsbezogene Erfolgserwartung sowie den teilnahmeförderlichen und -hinderlichen Wert signifikant vorhersagt. Eine Prüfung der prädiktiven Validität der Interaktion von fachlicher/sozialer und persönlicher Einstellungsdimension (i. S. von Wert × Erwartung) zeigt außerdem, dass eine stark ausgeprägte persönliche Einstellungsdimension (i. S. der Selbstwirksamkeit) die teilnahmehinderlichen Wertüberzeugungen reduzieren kann. Die Diskussion thematisiert theoretische und praktische Implikationen der Befunde.
Lösliche Guanylatzyklase(sGC)-Stimulation mit Vericiguat
Authors: Haase Nadine , Kedziora Sarah M. , Müller Dominik Nikolaus , Dechend Ralf 
Published: October 2022

Zusammenfassung
Hintergrund
Aufgrund der neuen Leitlinien der European Society of Cardiology (ESC) zur Diagnostik und Behandlung der akuten und chronischen Herzinsuffizienz (McDonagh et al. 2021) kann Vericiguat (Verquvo®) zur Behandlung von erwachsenen Patienten mit symptomatischer, chronischer Herzinsuffizienz und reduzierter Ejektionsfraktion, die trotz Standardtherapie nach einem kürzlich aufgetretenen Dekompensationsereignis mit erforderlicher intravenöser (i.v.) Therapie stabilisiert wurden, mit in die Therapie aufgenommen werden.

Ziel der Arbeit
Die vorliegende Übersichtsarbeit fasst die Entwicklung von Vericiguat, einem löslichen Guanylatzyklase-Stimulator (sGC-Stimulator), als konsequente Umsetzung eines neuartigen pharmakologischen Therapieansatzes zur Behandlung der Herzinsuffizienz zusammen und bietet über die Charakterisierung dieses erstmalig untersuchten Patientenkollektivs wertvolle Ansätze für die praktische Verwendung.

Ergebnisse
Die beiden wesentlichen Studien in der klinischen Entwicklung von Vericiguat – SOCRATES-Reduced und VICTORIA – haben die Wirksamkeit und Sicherheit von Vericiguat eindrucksvoll belegt. Der primäre Wirksamkeitsendpunkt der VICTORIA-Studie „kardiovaskulärer Tod oder Herzinsuffizienz-bedingte Hospitalisierung“ wurde im Vericiguat-Arm signifikant im Vergleich zu Placebo reduziert. Relevante Subgruppenanalysen sowie Sicherheitsdaten bestätigen dieses Ergebnis und unterstützen die sichere Anwendung in diesem Hochrisikokollektiv.

Diskussion
Die vorliegenden Daten lassen die Schlussfolgerung zu, dass Vericiguat effektiv und sicher zu einer bestehenden Therapie mit den empfohlenen Herzinsuffizienzmedikamenten hinzugefügt werden kann. Es ist zu erwarten, dass im Praxisalltag die Zieldosis von 10 mg verlässlich erreicht und gehalten werden kann. Vericiguat stellt daher eine neuartige, einfache und sichere Therapieoption in einem vulnerablen Patientenkollektiv dar, für das es bisher kaum medikamentöse Behandlungsoptionen gab.
Pathogenic potential and antimicrobial resistance of Staphylococcus pseudintermedius isolated from human and animals
Authors: Glajzner Paulina , Szewczyk Eligia M. , Szemraj Magdalena 
Published: October 2022

AbstractCrossing of interspecies barriers by microorganisms is observed. In recent years, Staphylococcus pseudintermedius—a species formerly thought to be animal—has also been isolated from human clinical materials. Many virulence factors are responsible for the colonization, which is the first step an infection, of the new host organism. We analyzed the factors influencing this colonization as well as susceptibility to antibiotics in fourteen S. pseudintermedius strains isolated from clinical cases from humans and animals. The occurrence of genes responsible for binding elastin, fibronectin, and fibrinogen and some phenotypic features, although different between strains, is comparable in both groups. However, the animal isolates had more genes coding for virulence factors. All isolates tested had the exfoliating toxin gene and the leukotoxin determining genes, but only the human strains had enterotoxin genes. The assessment of antibiotic resistance of strains of both groups indicates their broad resistance to antibiotics commonly used in veterinary medicine. Antibiotic resistance was more common among animal isolates. The multilocus sequence typing analysis of the studied strains was performed. The results indicated a large diversity of the S. pseudintermedius population in both studied groups of strains. Equipped with important virulence factors, they showed the ability to infect animals and humans. The clonal differentiation of the methicillin-susceptible strains and the multidrug resistance of the strains of both studied groups should be emphasized. The considerable genetic diversity of strains from a limited geographical area indicates the processes of change taking place within this species. Thus, careful observation of the ongoing process of variation is necessary, as they may lead to the selection of S. pseudintermedius, which will pose a significant threat to humans.
Circulating Irisin Level as a Biomarker for Pure Aortic Stenosis and Aortic Valve Calcification
Authors: Wang Shan-shan , Li Jia-min , Hu Po , Guo Yu-chao , Liu Xian-bao , Wang Jian-an , Chen Han 
Published: October 2022

AbstractIrisin, a myokine mainly secreted by skeletal and cardiac muscles, is actively involved in cardiovascular diseases. However, whether irisin is associated with aortic stenosis remains unknown. Two hundred ninety-three severe AS patients who underwent transcatheter aortic valve implantation were enrolled and followed-up for 35 months on average. Enzyme-linked immunosorbent assay (ELISA) was applied to measure circulating irisin levels. Patients were divided into two groups based on the median plasma irisin level. We found that high plasma irisin levels were independently associated with pure aortic stenosis (PAS) after adjusting for age, body mass index, history of peripheral vascular disease, and creatinine (OR = 3.015, 95% CI 1.775–5.119, P < 0.001). ROC curve analysis showed a significant predictive value of irisin for PAS (AUC = 0.647, 95% CI 0.583–0.711, P < 0.001). The severity of aortic valve calcification was negatively associated with plasma irisin levels (P < 0.05). In conclusion, irisin is an independent predictor for PAS and is negatively associated with the severity of aortic valve calcification.
Mindfulness and Nonattachment-To-Self in Athletes: Can Letting Go Build Well-being and Self-actualization?
Authors: Lewis Kelsey J. , Walton Courtney C. , Slemp Gavin R. , Osborne Margaret S. 
Published: October 2022

Abstract

Objectives
Many athletes seek to embody a mindful state when competing. However, amidst competitive pressures and demands to perform at their best, athletes report similar or even higher levels of psychological distress than community norms. Despite the widespread use of mindfulness as a sport performance strategy, few studies have examined the mechanisms behind mindfulness, and the role egoic fixation plays, in athlete well-being. The current study aimed to explore the role of mindfulness and nonattachment-to-self (NTS) in athlete well-being and self-actualization.

Methods
An online survey was administered to 223 athletes (53.8% men), predominantly from Australia and New Zealand. Two-thirds of the sample were elite athletes. We used structural equation modeling to test a hypothesized model whereby NTS mediates the relationship between mindfulness and both well-being and self-actualization. We also tested an alternative model that positioned mindfulness as the mediator between NTS as the predictor, and well-being and self-actualisation as outcomes.

Results
Both models exhibited similar fit to the data, although the alternative model displayed slightly better fit than the hypothesized model. Partial mediation was found for the hypothesized and alternative models, highlighting both as plausible pathways. Interestingly, NTS was found to exhibit a stronger effect on well-being and self-actualization than mindfulness, suggesting it may play a central role in athlete well-being.

Conclusion
The findings highlight the need for researchers to consider mindfulness and NTS in tandem, acknowledging the role that egoic fixation plays in athlete mental health—especially when designing mindful-based interventions for athletes.