bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant litter chemistry controls coarse‐textured soil carbon dynamics
Authors: Huys Raoul , Poirier Vincent , Bourget Malo Y. , Roumet Catherine , Hättenschwiler Stephan , Fromin Nathalie , Munson Alison D. , Freschet Grégoire T. 
Published: September 2022

Abstract

As soils store more carbon (C) than the Earth's atmosphere and terrestrial biomass together, the balance between soil C uptake in the form of soil organic matter (SOC) and release as CO2 upon its decomposition is a critical determinant in the global C cycle regulating our planet's climate. Although plant litter is the predominant source of C fuelling both soil C build‐up and losses, the issue of how litter chemistry influences this balance remains unresolved.

As a contribution to solving that issue, we traced the fate of C during near‐complete decomposition of 13C‐labelled leaf and root litters from 12 plant species in a coarse‐textured soil. We separated the soil organic carbon into mineral‐associated organic matter (MAOM) and particulate organic matter (POM) pools, and investigated how 14 litter chemical traits affected novel SOC formation and native SOC mineralization (i.e. the priming effect) in these soil fractions.

We observed an overall net increase in SOC due to the addition of litter, which was stronger for root than for leaf litters. The presumed stable MAOM‐C pool underwent both substantial stabilization and mineralization, whereas the presumably less stable POM‐C pool showed substantial stabilization and reduced mineralization. Overall, the initial increase in soil C mineralization was fully counterbalanced by a later decrease in native soil C mineralization. POM‐C formation as well as MAOM‐C formation and mineralization were positively related to the initial litter lignin concentration and negatively to that of the nitrogen leachates, whereas the opposite was observed for POM‐C mineralization.

Synthesis. Our results highlight the importance of litter chemical traits for SOC formation, and stabilization, destabilization and mineralization. In our coarse‐textured soil, the amount of MAOM‐C did not change despite large C fluxes through this pool. The litter chemical traits that drove these processes differed from those frequently reported for fine‐textured soils far from mineral‐associated C saturation. To account for these discrepancies, we propose an integrative perspective in which litter quality and soil texture interactively control soil C fluxes by modulating several SOC stabilization and destabilization mechanisms. Irrespective, our results open new critical perspectives for managing soil C pools globally.
Salvianolic acid B, a new type I IRE1 kinase inhibitor, abrogates AngII‐induced angiogenesis by interacting with IRE1 in its active conformation
Authors: Fan Fangtian , Liu Fang , Shen Peiliang , Tao Li , Zhang Hongjiang , Wu Hongyan 
Published: September 2022

AbstractAngiotensin II (AngII)‐mediated pathological angiogenesis is one of the important factors promoting the progression of atherosclerosis, tumour metastasis, and diabetic retinopathy. Here, we first demonstrate that salvianolic acid B (Sal B) attenuated AngII‐induced angiogenesis by downregulating the IRE1/ASK1/JNK/p38MAPK signalling pathway and protected vascular endothelial cells from hypoxia‐induced damage. These pharmacological consequences could be ascribed to the unique interactions between Sal B and the ATP‐binding cavity of IREIα, leading to bi‐directional roles of IRE1 kinase and endonuclease activity; this may possibly be one of the essential mechanisms of the bi‐directional regulation of angiogenesis in different conditions. Moreover, our results indicated that IRE1 was a novel anti‐angiogenesis target and type I IRE1 kinase inhibitor (e.g., Sal B, APY29) and might be a potentially eligible low‐toxicity drug for treating AngII‐mediated pathological angiogenesis.
Individual socioeconomic status and risk of out‐of‐hospital cardiac arrest: A nationwide case–control analysis
Authors: Lee Sun Young , Park Jeong Ho , Choi Young Ho , Lee Jungah , Ro Young Sun , Hong Ki Jeong , Song Kyoung Jun , Shin Sang Do 
Published: September 2022

AbstractObjectivesArea‐level socioeconomic status (SES) is associated with the incidence of out‐of‐hospital cardiac arrest (OHCA); however, the effects of individual‐level SES on OHCA occurrence are unknown. This study investigated whether individual‐level SES is associated with the occurrence of OHCA.MethodsThis case–control study used data from the nationwide OHCA registry and the National Health Information Database (NHID) in Korea. All adult patients with OHCA of a medical etiology from 2013 to 2018 were included. Four controls were matched to each OHCA patient based on age and sex. The exposure was individual‐level SES measured by insurance type and premium, which is based on income in Korea. National Health Insurance (NHI) beneficiaries were divided into four groups (Q1–Q4), and medical aid beneficiaries were separately classified as the lowest SES group. The adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the outcomes were calculated. Stratified analyses were conducted according to age and sex.ResultsA total of 105,443 cases were matched with 421,772 controls. OHCA occurred more frequently in the lower SES groups. Compared with the highest SES group (Q1), the aORs for OHCA occurrence increased as the SES decreased (aORs [95% CI] were 1.21 [1.19–1.24] for Q2, 1.33 [1.31–1.36] for Q3, 1.32 [1.30–1.35] for Q4, and 2.08 [2.02–2.13] for medical aid). Disparity by individual‐level SES appeared to be greater in males than in females and greater in the young and middle‐aged adults than in older adults.ConclusionsLow individual‐level SES was associated with a higher probability of OHCA occurrence. Efforts are needed to reduce SES disparities in the occurrence of OHCA.
Neuropsychological functioning and suicidal behaviours in patients with first‐episode psychosis: A systematic review
Authors: Sánchez‐Gutiérrez Teresa , Barbeito Sara , Gómez‐Juncal Rocío , Rodríguez‐Ortega Elisa , Becerra‐García Juan Antonio , Calvo Ana 
Published: September 2022

AbstractIntroductionSuicidal behaviour is particularly frequent in patients with psychosis. Therefore, prevention is a key objective of mental health policies. The aim of the current work is to systematically review the association between neurocognitive functioning and suicidal behaviour in patients with first‐episode psychosis (FEP).Material and MethodsOf the 3051 studies reviewed, only 7 met the inclusion criteria. Documents in English from their earliest date of coverage until January 2022 were searched for in the following databases: PubMed, Science Direct, Web of Science, Cochrane Library, PsycINFO (ProQuest), and Springerlink. We used the PICO strategy to collect and categorize the data from each selected manuscript.ResultsOverall, the results showed that the risk of suicidal behaviour is higher for FEP patients in the presence of a number of factors: poorer general neuropsychological functioning (except for working memory), poorer social cognition, more depressive symptoms, longer duration of untreated psychosis, higher awareness of the illness, poorer premorbid adjustment, and more frequent cannabis use.DiscussionComprehensive general neuropsychology and assessment of social cognition, together with routine clinical record keeping, may help to identify FEP patients at a greater risk of attempting suicide.
Genome assembly and annotation of Periplaneta americana reveal a comprehensive cockroach allergen profile
Authors: Wang Lingyi , Xiong Qing , Saelim Nawannaporn , Wang Lin , Nong Wenyan , Wan Angel Tsz‐Yau , Shi Mai , Liu Xiaoyu , Cao Qin , Hui Jerome Ho Lam , Sookrung Nitat , Leung Ting‐Fan , Tungtrongchitr Anchalee , Tsui Stephen Kwok Wing 
Published: September 2022

AbstractBackgroundOne of the most common cockroach types in urban areas, the American cockroach (Periplaneta americana), has been reported to impose an increased risk of allergies and asthma. Limited groups of allergens (Per a 1–13) have been identified in this species due to the lack of genome‐related information.MethodsTo expand the allergen profile of P. americana, genomic, transcriptomic, and proteomic approaches were applied. With the support of a high‐quality genome assembled using nanopore, Illumina, and Hi‐C sequencing techniques, potential allergens were identified based on protein homology. Then, using enzyme‐linked immunosorbent assay, selected allergens were tested in Thai patients allergic to P. americana.ResultsA chromosomal‐level genome of P. americana (3.06 Gb) has been assembled with 94.6% BUSCO completeness, and its contiguity has been significantly improved (N50 = 151 Mb). A comprehensive allergen profile has been characterized, with seven novel groups of allergens, including enolase (Per a 14), cytochrome C (Per a 15), cofilin (Per a 16), alpha‐tubulin (Per a 17), cyclophilin (Per a 18), porin3 (Per a 19), and peroxiredoxin‐6 (Per a 20), showing IgE sensitivity in enzyme‐linked immunosorbent assay. A new isoallergen of tropomyosin (Per a 7.02) and multiple potential isoallergens of Per a 5 were revealed using bioinformatics and proteomic approaches. Additionally, comparative analysis of P. americana with the closely related Blattodea species revealed the possibility of cross‐reaction.ConclusionThe high‐quality genome and proteome of P. americana are beneficial in studying cockroach allergens at the molecular level. Seven novel allergen groups and one isoallergen in Per a 7 were identified.
Vaginal delivery rate by near delivery sonographic weight estimation and maternal stature among nulliparous women
Authors: Meyer Raanan , Yinon Yoav , Levin Gabriel 
Published: September 2022

AbstractBackgroundWe evaluated the risk for cesarean delivery among term nulliparous women, categorized by maternal stature and recent sonographic estimated fetal weight (EFW).MethodsA retrospective study including singleton deliveries of nulliparous women between 2011 and 2020, with sonographic EFW within 1 week of delivery. We categorized maternal height into five groups: ≤150, 151‐155, 156‐160, 161‐165, and ≥166 cm. Fetal weight estimation was categorized into five groups as well: ≤2500 g, 2501‐2999, 3000‐3499, 3500‐3999, and ≥4000 g.ResultsOverall, 13 107 deliveries were included. The cesarean delivery rate was inversely correlated with maternal height, ranging from 41.0% in group 1 to 13.1% in group 5. The vaginal delivery rate ranged from 33.3% in maternal height group 1 with EFW of ≥4000 g to 85% in maternal height group 5 with EFW of ≤2500 g. In weight categories above 2500 g, maternal height correlated significantly with vaginal delivery rate, except in weight category ≥4000 g in which vaginal delivery rate ranged around 30% in maternal height categories 1‐3 and increased significantly in groups 4‐5 to 50‐60%. In multivariable logistic regression analysis, EFW was independently associated with CD for EFW categories 3500‐3999 and ≥4000 g [aOR 95% CI 1.49 (1.08‐2.06) and 4.39 (2.97‐6.50), respectively]. Maternal height was negatively associated with CD [aOR 95% CI 0.67 (0.64‐0.70)] for each increase in maternal height group.ConclusionsCesarean delivery rate was inversely correlated with maternal height, ranging from 41.0% among women ≤150 cm to 13.1% among women ≥166 cm. Maternal height and EFW of ≥3500 g are independently associated with CD rates among term nulliparous women.
Enhancement of astrocytic gap junctions Connexin43 coupling can improve long‐term isoflurane anesthesia–mediated brain network abnormalities and cognitive impairment
Authors: Dong Rui , Lv Pin , Han Yuqiang , Jiang Linhao , Wang Zimo , Peng Liangyu , Ma Zhengliang , Xia Tianjiao , Zhang Bing , Gu Xiaoping 
Published: September 2022

AbstractAimAstrocytes are connected by gap junctions Connexin43 (GJs‐Cx43) forming an extensive intercellular network and maintain brain homeostasis. Perioperative neurocognitive disorder (PND) occurs frequently after anesthesia/surgery and worsens patient outcome, but the neural circuit mechanisms remain unclear. This study aimed to determine the effects of the GJs‐Cx43–mediated astrocytic network on PND and ascertain the underlying neural circuit mechanism.MethodsMale C57BL/6 mice were treated with long‐term isoflurane exposure to construct a mouse model of PND. We also exposed primary mouse astrocytes to long‐term isoflurane exposure to simulate the conditions of in vivo cognitive dysfunction. Behavioral tests were performed using the Y‐maze and fear conditioning (FC) tests. Manganese‐enhanced magnetic resonance imaging (MEMRI) and resting‐state functional magnetic resonance imaging (rs‐fMRI) were used to investigate brain activity and functional connectivity. Western blot and flow cytometry analysis were used to assess protein expression.ResultsReconfiguring the astrocytic network by increasing GJs‐Cx43 expression can modulate 22 subregions affected by PND in three ways: reversed activation, reversed inhibition, and intensified activation. The brain functional connectivity analysis further suggests that PND is a brain network disorder that includes sleep‐wake rhythm–related brain regions, contextual and fear memory–related subregions, the hippocampal‐amygdala circuit, the septo‐hippocampal circuit, and the entorhinal‐hippocampal circuit. Notably, remodeling the astrocytic network by upregulation of GJs‐Cx43 can partially reverse the abnormalities in the above circuits. Pathophysiological degeneration in hippocampus is one of the primary hallmarks of PND pathology, and long‐term isoflurane anesthesia contributes to oxidative stress and neuroinflammation in the hippocampus. However, promoting the formation of GJs‐Cx43 ameliorated cognitive dysfunction induced by long‐term isoflurane anesthesia through the attenuation of oxidative stress in hippocampus.ConclusionEnhancing GJs‐Cx43 coupling can improve brain network abnormalities and cognitive impairment induced by long‐term isoflurane anesthesia, its mechanisms might be associated with the regulation of oxidative stress and neuroinflammation.
Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma
Authors: Imanishi Sachiko , Nagata Shoko , Fujita Toshitsugu , Fujii Hodaka 
Published: September 2022

AbstractHepatocellular carcinoma (HCC) is the most predominant type of liver cancer and is frequently fatal. Alpha‐fetoprotein, alpha‐fetoprotein‐L3, and protein induced by vitamin K absence or antagonist‐II are used as biomarkers to diagnose HCC. However, these biomarkers are not highly specific, especially for early‐stage HCC diagnosis; therefore, more specific biomarkers are needed. Recently, circular RNA (circRNA) biomarkers have been used to diagnose several intractable diseases. In this study, we sought to identify circRNA biomarkers for the specific diagnosis of HCC. To this end, we compared the expression levels of circRNAs in primary HCC and normal tissues using publicly available RNA‐seq data. Our analysis revealed that the expression levels of eight circRNAs were altered in primary HCC tissues compared with normal tissues. To confirm our findings, we examined the expression levels of selected circRNAs in HCC cell lines and normal hepatocytes. The expression level of hsa_circ_0001438, a circRNA that was downregulated in primary HCC, was lower in poorly and well‐differentiated HCC cell lines than in normal hepatocytes. By contrast, the expression level of hsa_circ_0000417, which was increased in primary HCC, was strongly upregulated in a well‐differentiated HCC cell line compared with normal hepatocytes. Thus, hsa_circ_0001438 and hsa_circ_0000417 might be potential biomarkers for the specific diagnosis of HCC. The experimental strategy described here, using publicly available RNA‐seq data, is a useful and cost‐effective method of identifying circRNA biomarkers.
Circadian variation of serum leptin and adipose tissue changes in children
Authors: Zenno Anna , Brady Sheila M. , Faulkner Loie M. , Ballenger Kaitlin L. , Fatima Syeda , Yanovski Jack A. 
Published: September 2022

SummaryBackgroundHigher morning serum leptin values are associated with larger adipose tissue gains in children; however, it is unclear if leptin circadian variation is itself associated with adipose tissue changes during growth.ObjectiveWe studied the association of circadian variation in leptin with change in total body fat mass (TBFM), total body percentage fat (%FM), and trunk fat mass (TrFM).MethodsBaseline serum samples for leptin were obtained every 3 h for 24 h from 130 children (baseline age 9.6 ± 2.5y; 51.1% male; BMI‐Z 1.59) with mean follow‐up of 11.1 ± 4.0y and underwent dual‐energy x‐ray absorptiometry. ANCOVA models examined change in TBFM, %FM, or TrFM as dependent variables and number of years of follow‐up, sex, race, baseline age, pubertal status, initial visit body composition, and initial visit serum leptin circadian variables (maximal diurnal leptin [acrophase], diurnal amplitude, and percentage change of amplitude) as independent factors.ResultAlthough initial visit mesor (24 h average) leptin was positively associated with initial visit TBFM (r2 = 0.78, p < 0.001), %FM (r2 = 076, p < 0.001), and TrFM (r2 = 0.71, p < 0.001), none of the circadian leptin variables studied was significantly associated with change in TBFM, %FM, or TrFM.ConclusionWe found no evidence that circadian variation in serum leptin concentrations during childhood is associated with long‐term changes in children's adiposity.
Intracardiac echocardiography from coronary sinus
Authors: Garg Jalaj , Kewcharoen Jakrin , Bhardwaj Rahul , Contractor Tahmeed , Jain Sarika , Mandapati Ravi 
Published: September 2022

AbstractIntracardiac echocardiography (ICE) has become an essential tool and is an integral part of percutaneous interventional and electrophysiology (EP) procedures. Intracardiac echocardiography offers real‐time, high‐quality, near‐field evaluation of cardiac anatomy. Standard ICE imaging includes placing the catheter in the right atrium (RA), right ventricle (RV), or left atrium (LA, via the transeptal approach). Coronary sinus echocardiography (CSE) is another alternative, where the ICE catheter is positioned in the coronary sinus (CS). This approach offers better catheter stability and allows operators to visualize cardiac structure with particularly excellent views of the LA, LAA, left ventricle (LV), and mitral annulus. Additionally, CSE is an attractive alternative in cases with unfavorable interatrial septum or fossa ovalis anatomical features that could lead to difficulty advancing ICE catheter in left atrium. In this article focusing on CSE, we provide illustration‐based guidance to help operators identify critical cardiac structures from CSE.
A new species of Bathysphyraenops from the Indian Ocean with comments on the genus (Teleostei: Acropomatiformes: Howellidae)
Authors: Rajakrishnan Rajeev , Rajeeshkumar Meleppura , Cubelio Sherine Sonia , Prokofiev Artem M. 
Published: September 2022

AbstractA new species, Bathysphyraenops radhae, is described from the equatorial western Indian Ocean. It resembles Bathysphyraenops declivifrons in the shape of snout and number of pseudobranchial filaments in adults but can be readily distinguished from all known members of Howellidae by its characteristically armed preopercle and in strong reduction or absence of spinules on scales around the pectoral fin. The genus Bathysphyraenops is rediagnosed, and the characteristics useful in diagnosing the howellid genera are briefly discussed. The nominal genus Schistoperca is synonymized with Bathysphyraenops. A key to the species of Bathysphyraenops is provided.
A randomized controlled trial of a 5‐year marriage checkup booster session for a subsample of responder couples
Authors: Leth‐Nissen Astrid B. , Fentz Hanne N. , Stadler Gertraud , Trillingsgaard Tea L. 
Published: September 2022

AbstractThis study examined maintenance and booster effects of a brief couple intervention, the Marriage Checkup (MC), across 5 years. A subsample of 63 couples who benefitted from two previous MCs (responder couples), were randomly assigned to a third MC or control. Before randomization (at 4‐years‐9‐months), the responder sample had maintained small to medium effects on two measures of relationship functioning. After randomization, we found no significant between‐group effects. Yet, within‐group analyses revealed that while control couples showed flat trajectories in all outcomes after the 4‐year‐9‐months baseline, couples receiving a third MC (at Year 5) reported small to medium improvements in three measures of relationship functioning and maintained follow‐up effect in one measure. Findings indicate that couples who initially improved from the MC can maintain some of their improvements over long periods. The potential of boosting such improvements with recurrent MCs is a relevant target for further investigation in larger samples.
Changes in couple, parenting, and individual functioning following Family Expectations program participation
Authors: Barton Allen W. , Gong Qiujie , Stanley Scott M. , Rhoades Galena K. 
Published: September 2022

AbstractThe current study investigated changes in couple, parenting, and individual functioning following participation in Family Expectations, a relationship and parenting education program for new or expectant parents. The sample comprised 339 couples who participated in most sessions of the Family Expectations program and completed assessments at three different time points over a 12‐month period. Study analyses examined: (a) change shortly following completion of the program, (b) associations between short‐term change and subsequent change in outcomes at 12‐month follow‐up, and (c) differences in short‐term change between married and unmarried couples. Significant improvements were observed in all three domains at short‐term follow‐up. Short‐term changes, particularly for psychological distress, were predictive of long‐term change in multiple domains. Few moderation effects by marital status were evident; those that appeared suggested stronger effects for married participants compared to unmarried. Study findings inform ongoing discussions into the utility of federally‐funded relationship and parenting programming.