bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Exposure To Cooking Oil Fumes During Pregnancy And Autistic‐Like Behaviors In Chinese Preschoolers
Authors: Yang Jian-Hui , Strodl Esben , Wu Chuan-An , Hou Xiang-Yu , Yin Xiao-Na , Wen Guo-Min , Sun Deng-Li , Xian Dan-Xia , Chen Jing-Yi , Chen Ying-Jie , Chen Jing , Chen Wei-Qing 
Published: February 2022

Abstract
There is growing evidence that cooking oil fumes (COFs) are harmful indoor air pollutants. However, there is a dearth of research investigating whether maternal COFs exposure during pregnancy may affect children’s autistic-like behaviors in China. This study aimed to explore this association, and examine the effects of different cooking fuels and ventilation methods used by mothers on the presence of autistic-like behaviors. This study analyzed the survey data of the Longhua Child Cohort Study in 2017 with a total of 62372 child-caregiver dyads enrolled in this study. A self-administrative questionnaire was used to collect information on socio-demographic characteristics, cooking habits during pregnancy, and autistic-like behaviors (measured using the Autism Behavior Checklist). After adjusting for potential confounders, the results showed that compared with children whose mothers never cooked during pregnancy, children whose mothers cooked sometimes, often, always during pregnancy had the higher risk of autistic-like behaviors. As the amounts of COFs exposed to and the frequency of cooking during pregnancy increased, the risk of a child’s autistic-like behaviors also increased. Mothers using natural gas as cooking fuels had a lower risk of their child having autistic-like behaviors, compared with mothers using coal or other cooking fuels. Furthermore, pregnant women using ventilation measures during cooking significantly decreased likelihood of the presence of autistic-like behaviors in their children. These results suggest that maternal exposure to COFs during pregnancy may increase the likelihood of the presence of autistic-like behaviors in offspring. These findings support a recommendation that pregnant women should avoid exposure to COFs and use clean fuels and ventilation equipment in kitchens to reduce the risk of autistic-like behaviors in children.
A comparative study on Fe(III)-chitosan and Fe(III)-chitosan-CTAB composites for As(V) removal from water: preparation, characterization and reaction mechanism
Authors: Jiang Changjin , Zhang Ting , Li Shuhui , Yang Zhaoguang 
Published: February 2022

Abstract
Fe(III)-chitosan and Fe(III)-chitosan-CTAB composites were prepared using an ionotropic gelation method. Various techniques were used to analyze the morphology, structure, and property of the adsorbents, including SEM, EDS, FT-IR, XPS, and zeta potential. Compared with Fe(III)-chitosan, Fe(III)-chitosan-CTAB was more effective for As(V) adsorption at a wide range of pH (3–8). The adsorption of As(V) onto Fe(III)-chitosan and Fe(III)-chitosan-CTAB could reach equilibrium in 20 min, and their maximum adsorption capacities were 33.85 and 31.69 mg g‒1, respectively. The adsorption kinetics was best described by the pseudo-second-order model (R2=0.998 and 0.992), whereas the adsorption isotherms was fitted well by the Freundlich model (R2=0.963 and 0.987). The presence of H2PO4− significantly inhibited the adsorption of As(V) onto Fe(III)-chitosan and Fe(III)-chitosan-CTAB, and humic acid also led to a slight decrease in As(V) adsorption by Fe(III)-chitosan-CTAB. Over 94% of As(V) at the initial concentration of no more than 5 mg L−1 was removed from real water by the two adsorbents. 1% (w/v) NaOH solution was determined to be the most suitable desorption agent. Fe(III)-chitosan and Fe(III)-chitosan-CTAB still maintained their initial adsorption capacities after five adsorption-desorption cycles. Based on different characterization results, both electrostatic attraction and surface complexation mechanisms played important roles in As(V) adsorption on Fe(III)-chitosan and Fe(III)-chitosan-CTAB.
Multi-layer Features Template Update Object Tracking Algorithm Based on SiamFC++
Authors: Lu Xiaofeng , Wang Xuan , Wang Zhengyang , Hei Xinhong 
Published: February 2022

Abstract
SiamFC++ only extracts the object feature of the first frame as a tracking template, and only uses the highest-level feature maps in both the classification branch and the regression branch, so that the respective characteristics of the two branches are not fully utilized. In view of this, the present paper proposes an object tracking algorithm based on SiamFC++. The algorithm uses the multi-layer features of the Siamese network to update template. First, FPN is used to extract feature maps from different layers of Backbone for classification branch and regression branch. Second, 3D convolution is used to update the tracking template of the object tracking algorithm. Next, a template update judgment condition is proposed based on mutual information. Finally, AlexNet is used as the backbone and GOT-10K as training set. Compared with SiamFC++, our algorithm obtains improved results on OTB100, VOT2016, VOT2018 and GOT-10k datasets, and the tracking process is real-time.
High MEIS3 level in colorectal cancer of stage II/III indicates poor prognosis
Authors: Li Haitao , Jian Ma , Ling Yang 
Published: February 2022

Abstract
Background: The wnt/beta-catenin signaling pathway plays indispensable roles in tumor budding and EMT process. Myeloid ecotropic viral insertion site 3 (MEIS3), a direct target of wnt/β-catenin, promotes vagal neural crest cells migrating into the gut tissue during development, while its role in cancer process remains unclear. So, we wonder the roles MEIS3 plays in CRC progression.Methods: We analyzed the association between MEIS3 protein expression and clinical stages of CRC patients. The cell biology methods were employed to analyze tumor cell migration and invasion activity. Finally, Kaplan-Meier analysis was used to exhibit the relationship between the proteins level and disease-free survival (DFS) and overall survival (OS) of CRC patients. Results: We found that MEIS3 was mainly located in highly invasive areas including growth front of CRC tissues. And its expression level increased with the CRC progression according clinical stages. In vitro analysis showed that MEIS3 may promote CRC cells metastasis by enhancing migration and invasion process. Stratified by expression level, the 5-year DFS of patients with high expression was lower than MEIS3 low expression patients (40.6% vs 61.7%, p<0.0001). We found that MEIS3 levels could be used to stratify patients at specific clinical stages. The 5-year DFS of stage II patients with MEIS3-high expression was significantly deteriorative than that of MEIS3-low expression (53.4% vs. 67.3%, p=0.0174). The 5-year DFS III patients with high MEIS3 expression was also significantly deteriorative than those of low MEIS3 expression (30.9% vs 49.5%, p=0.0038). Conclusion: This study intimates that MEIS3 may be a biomarker for recurrence of stage II/III patients, and promote the cancer cells metastasis process.
Maize grain yield enhancement in modern hybrids associated with greater stalk lodging resistance in high planting density: A case study in Northeast China
Authors: Cui Jingjing , Cui Zhengguo , Lu Yang , Lv Xiaofei , Cao Qingjun , Hou Yunlong , Yang Xiangyu , Gu Yan 
Published: February 2022

Abstract
Lodging resistance is a critical trait in modern maize breeding. To examine maize stalk lodging and related characteristics in response to increasing planting densities in modern hybrids. A 2-year field trial was conducted from 2018-2019 with two widely grown commercial hybrids (Xy335, Fm985) and three planting densities (LD, MD, HD) of 4.5, 6.5, and 8.5×104 plant/ha. Results showed new hybrid Fm985 had significantly higher grain yield and lower lodging rate in HD, while there was no significance at LD and MD. Compared to Fm985, old cultivar Xy335 had a significantly higher plant height, ear and gravity height, culm length (CL) across three planting density averages, while opposite stalk bending strength (SBS), dry weight per unit length (DWPU), cross-sectional area, and the content of cellulose and lignin in basal internode. The correlation and path analysis revealed that kernels amount per ear lodging rate directly contributed to maize grain yield, while lodging-related traits of SBS, stem lignin and DWPU and indirect effect on maize grain yield, suggesting modern hybrid maize yield enhancement associated with greater stalk lodging resistance in high planting density in Northeast China.
A State Level Analyses of Suicide and the COVID-19 Pandemic in Mexico
Authors: Borges Guilherme , Garcia Jose Angel , Pirkis Jane , Spittal Matthew J. , Gunnell David , Sinyor Mark , John Ann 
Published: February 2022

Abstract
Background: While suicide rates in high- and middle-income countries appeared stable in the early stages of the pandemic, we know little about within-country variations. We sought to investigate the impact of COVID-19 on suicide in Mexico’s 32 states and to identify factors that may have contributed to observed variations between states. Methods: Interrupted time-series analysis to model the trend in monthly suicides before COVID-19 (from Jan 1, 2010, to March 31, 2020), comparing the expected number of suicides derived from the model with the observed number for the remainder of the year (April 1 to December 31, 2020) for each of Mexico’s 32 states. Next, we modeled state-level trends using linear regression to study likely contributing factors at ecological level. Results: Suicide increased across Mexico during the first nine months of the pandemic (RR 1.03; 95%CI 1.01-1.05). Suicides remained stable in 19 states, increase in seven states (RR range: 1.12-2.04) and a decrease in six states (RR range: 0.46-0.88). Suicide RR at the state level was positively associated with population density in 2020 and state level suicide death rate in 2019. Conclusions: The COVID-19 pandemic had a differential effect on suicide death within the 32 states of Mexico. Higher population density and higher suicide rates in 2019 were associated with increased suicide. As the country struggles to cope with the ongoing pandemic, efforts to improve access to primary care and mental health care services (including suicide crisis intervention services) in these settings should be given priority.
Spectrum of biopsy renal disease in central China: a nine-year retrospective study of 1929 cases
Authors: Zhang Jianjiang , Zhang Jin , Zeng Huiqin , Shi Peipei , Jia Wanyu , Liu Zhen 
Published: February 2022

Abstract
Objective To investigate the renal pathology and transitions of children who received a renal biopsy at the First Affiliated Hospital of Zhengzhou University between 2012 and 2020. Methods The clinical and pathological data of children with a renal biopsy were analyzed retrospectively. The changes in the distribution of pathological types were examined in age groups of 3 years (-1, -3, -6, -12, -16 years) and gender. Results 1928 children with renal biopsies were included in the analysis. The mean age of the children was 8.18±SD 3.40 years and the ratio of males to females was 1.71. The main pathological types of primary glomerular disease were minimal change disease (MCD) and IgA nephropathy, while the main pathological types of secondary glomerulonephritis were lupus nephritis and Henoch-Schonlein purpura (HSPN). The male to female ratio and age distribution between lupus nephritis and HSP were significantly different.
Scoring system for predicting postoperative pain after transarterial chemoembolization treatment in liver cancer
Authors: Wang Yun-Bing , Zeng Hou-Shuai , Salameen Haitham , Chen Long , Wang Jia-Guo 
Published: February 2022

Abstract
Purpose: Patients that experience severe postoperative pain are more reluctant to adhere the treatment. This study intends to identify the relevant risk factors and construct a scoring system for prediction. Materials and methods: Liver cancer patients that underwent the first TACE treatment at the Second Affiliated Hospital of Chongqing Medical University from January 2019 to December 2020 were collected. The 11-point numerical rating scale (NRS-11) was utilized to evaluate the patient's pain level. The patients were randomly divided into a training and a validation cohort. In the training cohort, the correlation between each parameter and the pain level after TACE was evaluated through logistic regression, and a risk prediction model was established. Finally, the predictive power of the model was verified in the validation cohort. Results: A total of 255 patients with liver cancer were included. In the training cohort, univariate analysis found postoperative pain was related to tumor number, tumor size, microsphere volume, and operation time. The above variables were then incorporated into the multivariate analysis to construct the prediction model, In the training and validation cohorts, the area under the curve (AUC) of the model used to predict moderate to severe pain response after TACE was 0.71 and 0.74, respectively. Additionally, we also created a nomogram for clinical use, patients with a total score greater than 72.90 are considered at a high risk of experiencing moderate to severe pain following TACE. Conclusion: This study successfully constructed and validated a scoring system for predicting moderate to severe pain after an initial TACE treatment.
Uric acid and cardiometabolic risk profile in youths with type 1 diabetes: sex-related associations
Authors: Bonito Procolo Di , Rosanio Francesco Maria , Marcovecchio Maria Loredana , Cherubini Valentino , Delvecchio Maurizio , Candia Francesca Di , Iafusco Dario , Zanfardino Angela , Iovane Brunella , Maffeis Claudio , Maltoni Giulio , Ripoli Carlo , Piccinno Elvira , Piona Claudia Anita , Ricciardi Maria Rossella , Schiaffini Riccardo , Franzese Adriana , Mozzillo Enza 
Published: February 2022

Abstract
The aim of this study was to investigate the association between uric acid (UA) and cardiometabolic risk factors (CMRFs) by sex in youths with type 1 diabetes (T1D). Retrospective data collected from 1323 youths (5-18 years; 716 boys) with T1D recruited in 9 Italian Pediatric Diabetes Centers were analyzed. CMRFs included UA, HbA1c, blood pressure (BP), cholesterol (TC), HDL, triglycerides (TG), neutrophils (N) and lymphocytes (L) count, glomerular filtration rate (eGFR) (calculated using Schwartz-Lyon equation). The distribution of CMRFs was analyzed in sex-specific tertiles of UA. In the whole study population, statistically significant differences were found across UA tertiles for age, BMI, daily insulin dose, HbA1c, HDL, TG, TG/HDL ratio, TC/HDL ratio, SPISE index, N/L ratio, systolic BP, eGFR (p =0.01-0.0001). The highest tertile of UA was associated with 1,5-3,6 fold increased risk of high TG/HDL ratio, TC/HDL ratio, high BP, and MRGFR, compared to the lowest tertile in boys. Instead, in girls the highest tertile of UA was associated with two-fold increased risk of TC/HDL ratio, N/L ratio and MRGFR. Uric acid may represent a useful marker for identifying youth with T1D at high cardiometabolic risk, and association appears to vary by sex.
Biomarker development for neonicotinoid exposure in soil under interaction with the synergist piperonyl butoxide in Folsomia candida
Authors: Bakker Ruben , Ekelmans Astrid , Xie Liyan , Vooijs Riet , Roelofs Dick , Ellers Jacintha , Hoedjes Katja M. , Gestel Cornelis A.M. van 
Published: February 2022

Abstract
Pesticide toxicity is typically assessed by exposing model organisms to individual compounds and measuring effects on survival and reproduction. These tests are time-consuming, labor-intensive and do not accurately capture the effect of pesticide mixtures. Moreover, it is unfeasible to screen the near infinite combinations of mixtures for synergistic effects on model organisms. Therefore, reliable molecular indicators of pesticide exposure have to be identified, i.e. biomarkers. These biomarkers can form the basis of rapid and economical screening procedures to assess the toxicity of pesticides even under synergistic interaction with other pollutants. In this study, we screened the expression patterns of eight genes for suitability as a biomarker for neonicotinoid exposure in the soil ecotoxicological model Folsomia candida (springtails). Springtails were exposed to the neonicotinoids imidacloprid and thiacloprid either alone or with various levels of piperonyl butoxide (PBO), which inhibits cytochrome P450 enzymes (CYPs): a common point of synergistic interaction between neonicotinoid and other pesticides. First, we confirmed PBO as a potency enhancer for neonicotinoid toxicity to springtail fecundity, and then used it as a tool to confirm biomarker robustness. We identified two genes that are reliably indicative for neonicotinoid exposure even under metabolic inhibition of CYPs by PBO, nicotinic acetylcholine receptor subunit alpha 1 (nAchR) and sodium-coupled monocarboxylate transporter (SMCT). These results can form the basis for developing high-throughput screening procedures for neonicotinoid exposure in varying mixture compositions.
Factors influencing depression in community-dwelling elderly patients with osteoarthritis of the knee in China: a cross-sectional study
Authors: Shang Shaomei , Zheng Xiaoyan , Wang Yaya , Jin Xiaoyan , Huang Hongjie , Chen Hongbo , Wang Yan 
Published: February 2022

Abstract
Background: Patients with knee osteoarthritis who experience depression might have worse health outcomes. The aim of the present study was to explore the occurrence of depression and the factors influencing depression in community-dwelling elderly patients with osteoarthritis of the knee in China. Methods: We conducted a cross-sectional, correlational descriptive study. The study included 214 participants aged 60 and older diagnosed with knee osteoarthritis.Results: The mean total score of depression was 4.43, and depression correlated with age, body mass index (BMI), education, frequency of falls, number of comorbidities, use of walking aids, taking pain relief or cartilage protectors, pain, stiffness, physical function, social support, mobility function and the muscle strength of lower extremities (r = -0.342 to 0.525). Analysis using hierarchical multiple regression demonstrated that falling frequency, using walking aids, the number of comorbidities, BMI, physical function, social support, and stair-climb test explained 40.8% of the variance in depression.Conclusions: The present study demonstrated that depression among elderly people with knee OA is a serious problem. Strategies to increase patients’ physical function, prevent falls, lose weight, treat comorbid conditions, and encourage them to increase positive social interaction, and engage in muscle strength training might relieve depression in these patients.
Efficacy Comparison of Tigecycline and Polymyxin B Against Carbapenem-Resistant Klebsiella Pneumoniae Infection in Intensive Care Units, a Multicenter Retrospective Study
Authors: Zhang Buyao , Hu Chenghuan , Deng Fuxing , Li Mingxia , Wu Ying , Xiao Xuefei , Zhou Xu , Wu Yanhong , Zhong Yanjun , Yan Shanshan , Zhao Shuangping 
Published: February 2022

Abstract
Aim: To investigate the efficacy of Tigecycline (TG) or polymyxin B(PB) against Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection in ICUs. Method: Electronic medical record systems were used to capture CRKP-infected patients who were treated with TG- or PB-based therapies from ICUs of four academic hospitals in Hunan, China. Propensity-score matching and logistic regression were used to compare efficacy and find prognostic factors.Results: Of the 236 patients, 106 received TG-based therapy (TG), 102 received PB-based therapy (PB), and 28 received a combination of TG and PB (TG+PB). PB group showed higher CRKP clearance (46.6% vs. 22.4%, P = 0.011) and complete bacterial clearance (32.8% vs. 15.5%, P = 0.051) than TG group. CRKP clearance (OR 0.312, 95%CI 0.159-0.612, P= 0.001), longer duration of PB (4-8 vs. > 8 days, OR 2.974, 95%CI 1.297-6.820, P= 0.010), and less vasoactive agents (1-4 vs. 0 days, OR 2.903, 95%CI 1.146-7.352, P= 0.025) were independent protective factors for 30-day mortality. Conclusions: About CRKP treatment in ICUs, PB-based therapy showed better bacterial clearance than TG-based therapy. CRKP clearance, longer duration of PB, and less vasoactive agents were independent protective factors for 30-day mortalit.
Efficacy of Endoscopic Endonasal Common Canaliculorhinostomy for Chronic Dacryocystitis with Small Lacrimal Sac in the Treatment of Failed Patients After EE-DCR
Authors: Li Sha , Zhang Yong 
Published: February 2022

Abstract
Background: Over the past 10 years, endoscopic endonasal dacryocystorhinostomy (EE-DCR）has a trend to gradually become the mainstream method for the treatment of nasolacrimal duct obstructive diseases , but the failure of EE-DCR is not rare in clinical treatment. Therefore, the study will explore the efficacy of treating patients with EE-DCR failure by endoscopic endonasal common canaliculorhinostomy (EE-CAR), in order to improve the success rate of reoperation in patients with EE-DCR failure. Method: Prospective non-randomized controlled study. Patients with EE-DCR failure caused by lacrimal sac nasal mucosal ostium atresia from April 2018 to January 2021 in Hankou Aier Eye Hospital were enrolled. They were divided into two groups according to the principle of voluntariness before surgery. Group A: underwent EE-CAR. Group B: underwent Endoscopic Endonasal Ostial Openning (EE-OO). The postoperative efficacy and complications of the two groups was compared. Results: 44 patients (48 eyes) were included in the comparative analysis, including 26 eyes in group A and 22 eyes in group B. Followed up at 6 months postoperative, the ostium of 22 eyes in group A remained open and the symptoms of tear overflow disappeared. The success rate of surgery was 84.62% (22/26), and 54.55% (12/22) in group B. There was significant difference between the two groups (P＜0.05). Conclusions: EE-CAR is better than conventional ostium opening in the treatment of patients with small lacrimal sac remnant after EE-DCR due to ostium atresia.
The effect of brown algae Nizimuddinia zanardinii on biochemical parameters and histopathological changes induced by cholestatic liver fibrosis in male rats
Authors: Nasiri Modara , Hajikhani Ramin , Mortazavi Pejman , Ebrahim Mahsa Ale , Bananaj Maryam 
Published: February 2022

Abstract
Background: Liver fibrosis is an important health problem in the world; the excessive deposition of type 1 collagen is the most characteristic feature of liver fibrosis. Algae is one of the natural resources that contains biologically active compounds that have anti-inflammatory, antioxidant and immune-stimulating properties. In this study, the effect of brown algae Nizimuddinia zanardinii on liver damage caused by cholestatic liver fibrosis in rats was evaluated.Material and Methods: 54 male rats were randomly classified in nine groups: control, sham, BDL, treatment and Nizimuddinia control. In the treatment group, after BDL, rats were given Nizimuddinia zanradinii extract via intragastric gavage for 45 days (once per day). parameters contains ALT, AST, ALP, cholesterol, triglyceride, albumin, total protein, SOD and CAT and histopathological assessments evaluated.Results: Treatment with Nizimuddinia zanardinii significantly weakened these alterations. In order to, in the treatment groups, TGF-β1 expression was severe, noticeable and low, respectively. In treatment groups, α-SMA expression was remarkable and mildly observed in hepatocytes and hyperplastic bile ducts, respectively.Conclusions: Based on this study, the N. zanardinii extract may protect the liver and have anti-fibrotic effects through its antioxidant and reducing the expression of TGF-β1 and α-SMA.