bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Hydrolysis and Bleaching Conditions on the Efficiency of Cellulose Microribbons Extraction from Coffee Parchment Through a Design of Experiments
Authors: Rodríguez Juan Esteban Henao , Rincón Daniel Escobar , Rojas Daniel Fernando Hincapié , Orjuela Iván Gerardo Cely , Socolovsky Leandro Martín , Rondón Dariana Geraldine Erazo , Calderón César Leandro Londoño 
Published: December 2022

Abstract
Cellulose microribbons were isolated from coffee parchment through acid hydrolysis, alkaline hydrolysis, and bleaching. Factorial design experiments allowed studying the influence of the chemical precursor concentrations and reaction times on the mass losses. TGA, SEM, XRD, and FT-IR techniques allowed characterized the coffee parchment hydrolyzed and bleached. Obtained results suggest that after acid hydrolysis, hemicellulose was the main fraction released from the coffee parchment, and after alkaline hydrolysis, lignin. Lignocellulosic compound dissolution produces a reduction/disappearance of some vibrational bands. This dissolution enhances the crystalline index and decreases the microrribons diameter. However, in coffee parchment, the microrribons are twisted giving the appearance of fibers with a minor diameter. The design of the experiment results suggests that the main factors during acid and alkaline hydrolysis are the concentration of the chemical precursors. In the bleaching process, a variation in the factors does not significantly influence the response variable. However, for brightness, the precursor concentration affects the cellulose quality. The optimal conditions for cellulose extraction from coffee parchment are 5% (v/v) of HNO3 by 2 h, 3%(m/v) NaOH by 1 h, and a 1:1 ratio of NaClO: CH3COOH by 45 min for bleaching.
sST2: A bridge between Sirt1/p53/p21 signal-induced senescence and TGF-β1/Smad2/3 regulation of cardiac fibrosis in mice viral myocarditis
Authors: Tan Jia jia , Wei Jing , Lu Hongxiang 
Published: December 2022

Abstract
Soluble interleukin 1 receptor-like 1 (sST2) is a novel predictor of poor outcomes, which is involved in inflammatory response and fibrosis of myocarditis. Cardiac fibrosis is a major cause of cardiovascular disease. Cellular senescence is a state of irreversible cell cycle arrest and studies have shown that senescence of myofibroblasts can limit or reduce myocardial fibrosis. Previous studies show that cellular senescence is associated with the progress of myocarditis, and cardiac fibroblasts is closely related to cardiac fibrosis. Therefore, we investigated the role of sST2 on senescence and fibrosis in mice cardiac fibroblasts (MCF). Meanwhile, its pathological role in mice viral myocarditis (VMC) was also investigated. In vitro experiments revealed that sST2 is beneficial to activate MCF by TGF-β1/Smad2/3 signaling and inhibit cell senescence by Sirt1/P53/P21 signaling pathway. CVB3-infected mice exhibited an increased deposition of collagen in the heart and decreased MCF senescence compared to WT mice while these pathological effects are reversed by anti-ST2 mAb. In addition, we found that inhibiting the senescence of MCF is beneficial to cardiac fibrosis and this effect is achieved by paracrine action. The present study reveals a new pathogenic pathway, sST2, which leads to cardiac fibrosis of VMC by inhibiting MCF senescence.
Biomineralization process of CaCO3 precipitation induced by Bacillus mucilaginous and its potential application in microbial self-healing concrete
Authors: Li Zhenfang , Liu Aizhu , Sun Chunhui , Li Haitao , Kong Zheng , Zhai Haoran 
Published: December 2022

Abstract
Microbial induced calcium carbonate precipitation (MICP) is widely common in nature, which belongs to biomineralization, and has been explored carefully in recent decades. The research studied the main factors including temperature, initial pH value and Ca2+ concentration on bacterial growth and carbonic anhydrase activity by a kind of bacteria producing extracellular carbonic anhydrase, and revealed the biomineralization process of MICP by Ca2+ concentration and calcification rate in alkali environment. Meanwhile, microbial healing agent containing spores and calcium nitrate was prepared for the early age concrete cracks. The self-healing efficiency was assessed by crack closure rate and water permeability repair rate. After 28 d healing time of dry-wet cycles, compared with reference, the crack closure rate with the crack width up to 0.339 mm could reach 95.62%, the water permeability repair rate was 87.54%. XRD analysis showed that the precipitations at the crack mouth were calcite CaCO3. Meanwhile, the self-healing mechanism of mortar cracks was discussed in detail. In particular, there is no other pollution in the whole mineralization process, and the self-healing system is environmentally friendly, which provides a novel idea and method for the application of microbial self-healing concrete.
Extending deep-sea benthic biodiversity inventories with environmental DNA metabarcodingExtending deep-sea benthic biodiversity inventories with environmental DNA metabarcoding
Authors: Oosthuizen Delene , Seymour Mathew , Atkinson Lara , Heyden Sophie von der 
Published: December 2022

Abstract
Inventories of biodiversity are crucial for helping support conservation efforts, yet the deep sea, which is the largest biome on earth remains vastly understudied. Recent advances in molecular detection methods offer alternative techniques for studying inaccessible ecosystems, including those at depth. In this study we utilized environmental DNA metabarcoding, a first for studying deep-sea benthic environments in southern Africa, to assess the biological diversity and possible effect of trawling on these communities in the study area. Utilising sediment samples collected across a depth gradient and targeting a region of the cytochrome oxidase I (COI) gene, we recovered 444 OTUs across a wide array of species and genera, although many OTUs could only be assigned to higher taxonomic levels. Results showed that biodiversity differed significantly across depth, suggesting that even at relatively small spatial scales (~ 6 km) eDNA derived biodiversity detected variation linked to the depth gradient. No significant effects of trawling could be detected from eDNA analyses. Comparison of the OTU database with known species inventories from the sampled area revealed little overlap, highlighting the need for expanding barcoding efforts of deep-sea species to aid future eDNA survey efforts. Overall our results suggest that, with increased barcoding efforts, a combined approach of eDNA metabarcoding and physical sampling could capture a greater proportion of benthic deep-sea biodiversity. This provides provides additional opportunities to underpin conservation and management decision-making in the region, such as evaluating potential sites for future protection.
Simple Algorithm for Judging Equivalence of Differential-Algebraic Equation Systems
Authors: Kato Shota , Zhang Chunpu , Kano Manabu 
Published: December 2022

Abstract
Mathematical formulas play a prominent role in science, technology, engineering, and mathematics (STEM) documents; understanding STEM documents usually requires knowing whether equation groups containing multiple equations are equivalent. However, existing tools cannot judge the equivalence of two equation groups; thus, we develop an algorithm to judge such an equivalence using a computer algebra system. The proposed algorithm first eliminates variables appearing only in either equation group. It then checks the equivalence of the equations one by one. If each equation in one equation group is equivalent to an equation in the other, the equation groups are judged equivalent; otherwise, non-equivalent. We generated 50 pairs of equation groups for evaluation. The proposed method accurately judged the equivalence of all pairs. This method is expected to facilitate comprehension of a large amount of mathematical information in STEM documents. Furthermore, this is a necessary step for machines to understand equations, including process models.
FDA approved Artificial Intelligence and Machine Learning (AI/ML)-Enabled Medical Devices: An updated 2022 landscape
Authors: Joshi Geeta , Bhandari Mukund 
Published: December 2022

Abstract
As artificial intelligence (AI) has been highly advancing in the last decade, machine learning (ML) based medical devices are increasingly used in healthcare. In this article, we did an extensive search on FDA database and performed analysis of FDA approved Artificial Intelligence and Machine Learning (AI/ML)-Enabled Medical Devices. We have presented all the listed AI/ML-Enabled Medical Devices according to the date of approval, medical specialty, implementation modality of Medical Devices, and anatomical site of use. Our summary includes the current landscape of FDA approved AI/ML-Enabled Medical Devices till date and different FDA approval pathways for medical devices which will help understand the overview of AI/ML-Enabled Medical Devices, and its overall trends.
UNTREATED GERIATRIC PHENYLKETONURIA WITH DELAYED DIAGNOSIS: AN ICF-BASED CASE REPORT
Authors: ÖZTÜRK Ferhat , KINIKLI Gizem İrem , KEREM GÜNEL Mintaze , ÖZALP İmran 
Published: December 2022

Purpose: Due to the nature of the phenylketonuria (PKU), it is difficult to categorize these patients' needs in a treatment management. The aim of this study was to evaluate an untreated geriatric PKU patient based on International Classification of Functioning, Disability and Health (ICF).
Method: The 72-year-old patient was presented with late-diagnosed and untreated PKU during his lifetime. The body structure and functions of the patient were determined by the Tinetti Scale, Sit-up test for 30-second, The Upper Extremity Index, Barthel Daily Life Activity Scale, Short Form- 36 Quality of Life scales were used to determine activities and limitations. Functional Ambulation Scale and Barthel Index were used for assessing participation.
Results: In this case, physical disabilities caused problems in his self-care and participation in life accompanying with cognitive problems, environmental and personal factors are negatively affecting his quality of life.
Conclusion: Many aspects of the geriatric PKU's participation in life and the parameters that need to be evaluated remain uncertain. For this reason, we suggest that healthcare professionals working with individuals with geriatric PKU patients might follow the ICF qualifiers and assessment methods as in this case report.
Pore volume and surface diffusion model to characterize batch adsorption of Cu(II) over chemically modified Cucurbita moschata biosorbent: simulation using gPROMS
Authors: Danish Mohd , Ansari Khursheed B. , Danish Mohammad , Zaidi Sadaf , Khalil Mohd Junaid , Aftab Rameez Ahmad 
Published: December 2022

Abstract
This work describes the successful application of the pore volume and surface diffusion (PVSD) model characterizing the batch adsorption of Cu(II) on a chemically modified Cucurbita moschata biosorbent. The PVSD model captures the convective transport of Cu(II) from the bulk solution to the biosorbent surface, followed by its surface and pore diffusion inside the biosorbent. The adsorption of Cu(II) is mimicked using the Langmuir isotherm. The algebraic, ordinary, and partial differential equations, involved in the PVSD model, are solved using the general process modeling system (gPROMS). The model simulation results, depicted by the Cu(II) concentration decay curve, show an excellent match with experimental data. The external mass transfer coefficient (≈10−3 m/s) indicated no restriction on approaching Cu(II) toward the biosorbent surface. Within the biosorbent, surface diffusion was dominant over pore volume diffusion. The statistical analysis of the PVSD model results has been done by calculating R2, Chi-square value, normalized standard deviation, p-value, and root-mean-square error. The PVSD model approach presented in this work could be beneficial to other heavy metal–biosorbent systems.
Land cover change evaluation based on eco-economic balance modeling
Authors: Tian Taorui , Zhang Shibin 
Published: December 2022

Abstract
Water supply is one of the important functions provided to humans by the ecosystem. Water supply by the ecosystem leads to sustainable economic development, ecological restoration and food security for human societies. Therefore, the evaluation of the water supply capacity of the ecosystem and the analysis of its spatial distribution features play an important role in the implementation of the plan for the protection and exploitation of water resources. Evaluation of ecological economic balance is of great importance in sustainable ecosystem management. This paper was conducted to develop the ecological economic balance structure based on the water supply and land cover changes. Land use was considered in four time periods from 2000 to 2021 with seven-year intervals to evaluate the process of land cover change and water availability. The results showed that the southern and eastern regions addressed a negative trend in the ecological economic balance. These areas have been affected by population growth and urbanization.
Advances in Durable Resistance to Diseases in Staple Food Crops: A Review
Authors: Kozub Natalia , Sozinova Oksana , Sozinov Igor , Karelov Anatolii , Janse Liliya , Mishchenko Lidiya , Borzykh Oleksandr , Blume Yaroslav 
Published: December 2022

Background:
At all stages of their development, plants are in permanent contact with causative agents of various diseases. Mechanisms of disease resistance and its durability in crops largely depend on the pathogen’s lifestyle, namely the nutrition mode and host range.

Objective:
The objective of this review is to consider the main advances in the production of genotypes with durable disease resistance in the globally important food crops, wheat, rice, and potato, as well as barley.

Results:
In wheat, durable resistance could be provided by the employment of various adult plant resistance genes against biotrophic pathogens, whose action commonly does not involve hypersensitivity response, as well as major quantitative genes, including mutants of susceptibility alleles, against necrotrophs via marker assisted selection (MAS). In barley, the most prominent example is the gene mlo conferring durable powdery mildew resistance, but it is compromised by higher susceptibility to some necrotrophic fungi. A few genes for broad-spectrum resistance against the rice blast and bacterial blight pathogens confirmed their effectiveness for decades, and they could be combined with effective R genes via MAS. Resistance to late blight of potato is mainly provided by R genes introgressed from wild potato species, which could be pyramided with quantitative trait loci. Genes for extreme resistance to potato viruses derived from related species provide durable and broad-spectrum resistance and could be effectively deployed in potato breeding using MAS. Silencing susceptibility genes by genome editing technologies is the most promising approach to produce plants with durable resistance to many pathogens in the crop species. Genetic transformation with genes for resistance-associated proteins or constructs providing silencing via RNA interference is an effective biotechnological method to generate plants with durable resistance against pathogens, especially viruses.

Conclusion:
Main advances in the production of crop plants with durable resistance are based on studies of molecular mechanisms of plant immunity and its special features for pathogens with different lifestyles via the use of biotechnological approaches such as MAS for pyramiding of monogenic quantitative resistance genes or qualitative R genes, changes in expression of certain genes associated with resistance, the introduction of transgenes, mutagenesis and genome editing aimed at silencing susceptibility genes.
Pilot Evaluation of Possible Airborne Transmission in a Geriatric Care Facility Using Carbon Dioxide Tracer Gas: Case Study
Authors: Ishigaki Yo , Yokogawa Shinji , Minamoto Yuki , Saito Akira , Kitamura Hiroko , Kawauchi Yuto 
Published: December 2022

Background
Although several COVID-19 outbreaks have occurred in older adult care facilities throughout Japan, no field studies focusing on airborne infections within these settings have been reported. Countermeasures against airborne infection not only consider the air change rate (ACR) in a room but also the airflow in and between rooms. However, a specific method has not yet been established by Japanese public health centers or infectious disease–related organizations.

Objective
In April 2021, 59 COVID-19 cases were reported in an older adult care facility in Miyagi, Japan, and airborne transmission was suspected. The objective of this study was to simultaneously reproduce the ACR and aerosol advection in this facility using the carbon dioxide (CO2) tracer gas method to elucidate the specific location and cause of the outbreak. These findings will guide our recommendations to the facility to prevent recurrence.

Methods
In August 2021, CO2 sensors were placed in 5 rooms where airborne infection was suspected, and the CO2 concentration was intentionally increased using dry ice, which was subsequently removed. The ACR was then estimated by applying the Seidel equation to the time-series changes in the CO2 concentration due to ventilation. By installing multiple sensors outside the room, advection outside the room was monitored simultaneously. Aerosol advection was verified using computer simulations. Although the windows were closed at the time of the outbreak, we conducted experiments under open-window conditions to quantify the effects of window opening.

Results
The ACR values at the time of the outbreak were estimated to be 2.0 to 6.8 h−1 in the rooms of the facility. A low-cost intervention of opening windows improved the ventilation frequency by a factor of 2.2 to 5.7. Ventilation depended significantly on the window-opening conditions (P values ranging from .001 to .03 for all rooms). Aerosol advection was detected from the private room to the day room in agreement with the simulation results. Considering that the individual who initiated the infection was in the private room on the day of infection, and several residents, who later became secondarily infected, were gathered in the day room, it was postulated that the infectious aerosol was transmitted by this air current.

Conclusions
The present results suggest that secondary infections can occur owing to aerosol advection driven by large-scale flow, even when the building design adheres to the ventilation guidelines established in Japan. Moreover, the CO2 tracer gas method facilitates the visualization of areas at a high risk of airborne infection and demonstrates the effectiveness of window opening, which contributes to improved facility operations and recurrence prevention.
Feminismos y derecho
Authors:   CEIICH-UNAM, Hernández Cervantes Aleida , Rubio Rufino Isabel Lucía 
Published: December 2022

El feminismo es tanto una teoría como un movimiento político. Sin embargo, no es una teoría unificada ni un movimiento social con un objetivo único, sino que se transforman según la época y la geografía donde se desarrolla. Las une a todas ellas, eso sí, una episteme común: el propósito de develar las desigualdades entre hombres y mujeres, explicar la subordinación histórica en la que han ellas han vivido y entender las causas que la originan para transformar ese orden social de género en el que se inscriben. Para entender esto, se proponen y utilizan metodologías de construcción del conocimiento con preguntas y discusiones distintas. Esa misma lógica se muestra en las críticas al Derecho por parte de las teorías feministas: miran el objeto, lo discuten y lo analizan desde los anteojos críticos del feminismo, pero hacen énfasis en elementos distintos. Así, este ensayo se propone resaltar las distintas críticas que se han realizado, desde una perspectiva feminista, al Derecho como parte del orden patriarcal y de la dominación masculina.
Movimiendo LGBTIQ+
Authors:   CIEG-UNAM, Torres Cruz César , Cabrera Sam Astrid Xanat 
Published: December 2022

Los estudios de género han tenido gran influencia en el desarrollo de los activismos de la diversidad y disidencia de género, sexo y afectiva. Asimismo, sus alianzas con los feminismos han permitido criticar el cisheteropatriarcado y crear estrategias de liberación sexogenérica. Este cuadernillo presenta una revisión documental y empírica de los movimientos lgbtiq+ en la zona metropolitana de la Ciudad de México desde la década de 1960 a la actualidad, con el propósito de dar cuenta de ciertas alianzas, desencuentros, reivindicaciones políticas y retos que han exprimentado. El activismo lgbtiq+ nos muestra la necesidad de reconocer como derechos humanos la libertad de actuar el género, el sexo o la condición sexual que mejor nos parezca, así como la capacidad de vincularse erótica y afectivamente de múltiples maneras con otras personas desde el consenso, y así posicionarlos dentro del panorama político general de nuestro país.
Community Survey on Blood Pressure and Levels of Blood Glucose, Cholesterol and Uric Acid Among People 45 Years and Above in Rural Villages of Bali
Authors: Sutisna (Scopus ID: 6506044199) Putu , I Ketut Tangking Widarsa  , I Wayan Darwata  , I Nengah Kapti  
Published: December 2022

OBJECTIVE. To observe the proportion of high blood pressure and high blood glucose, cholesterol and uric acid among people aged 45 years and older at the rural villages of Pejeng, Samplangan and Petak, in Gianyar Regency, Bali.
METHODS. The survey’s samples were all persons aged 45 years and over who came voluntarily to participate in the survey. Blood pressure was measured by mercury sphygmomanometer (Nova). Non-fasting levels of serum glucose, cholesterol, and uric acid were assessed by rapid test method using Easy Touch CGU apparatus. Each parameter studied was categorized as “high” and “normal” (blood pressure high: ≥140/90 mmHg; blood cholesterol high: ≥200mg/dl; blood glucose high ≥200mg/dl; blood uric acid high: >7.0 mg/dl, while other measurements below those values were categorized as normal. Data were analyzed descriptively and presented in tables of frequencies.
RESULTS. A total of 650 people aged 45 years and above participated in the survey (Samplangan village: 157 people, Pejeng village: 168 people, Petak village: 225 people). Of 650 study subjects examined, 43.8% had high serum cholesterol, 22.8% had high blood pressure, 26.3% had high serum uric acid, and 9.8% had high blood glucose. According to gender, 49.5% males and 38.2% females had high blood cholesterol, 27.3% males and 20.5% females had high blood pressure, 38.4% males and 20.3% females had high blood uric acid, and 11.1% males and 9.4% females had high blood glucose, respectively
CONCLUSIONS. In respective three villages greatest proportion of the study subjects had high serum cholesterol, followed in order of decreasing proportions by either high blood pressure or high blood uric acid, and the lowest proportion was with high blood glucose.