bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stay cable vibration mitigation: A review
Authors: Sun Limin , Chen Lin , Huang Hongwei 
Published: October 2022

Stay cables in cable-stayed bridges are subjected to various types of dynamic excitation mechanisms under environmental loads. The excited vibrations can have a large amplitude because of low vibration frequencies and small inherent damping of cables. As cables become longer (the longest cables are around 600 m in cable-stayed bridges with a main span of 1000 m), more modes are vulnerable to wind and rain-wind induced vibrations, posing challenges to vibration mitigation. This paper presents a comprehensive review of recent advances in stay cable vibration mitigation, including theoretical modeling of cable damping system and techniques for enhancing multimode damping. Recent results on cable damping measurements, understanding of cable vibrations, and relevant aerodynamic countermeasures are also recalled. The reflections can provide guidance for cable vibration control design of cable-supported bridges and for the maintenance/upgrade of cable vibration mitigation system of existing bridges.
Multiparty work relationships across Europe: A comparative overview
Authors: Maran Emiliano , Chieregato Elisa 
Published: October 2022

This article aims to contribute to the growing labour law discussion on Multiparty Work Relationships (MWRs), a term used to refer to temporary agency work, subcontracting, franchising and all other working arrangements in which the traditional bipartite structure is complicated by the presence of one or more intermediaries. Based on a large-scale comparative study which involved the participation of national experts from 30 European countries, the article seeks to shed light on MWRs across Europe, developing a tripartite classification of the various types of MWRs that can be found across Europe. On the basis of this classification, it provides a comparative overview of the extent to which these relationships are regulated and captured by national and EU labour law, presenting some specific domestic reactions to the problems emerging from the proliferation of these contractual arrangements.
Experiences of healthcare providers with eligible patients’ loss of decision-making capacity while awaiting medical assistance in dying
Authors: Variath Caroline , Peter Elizabeth , Cranley Lisa , Godkin Dianne 
Published: October 2022

Background: In Canada, under Bill C-14, patients who met all eligibility requirements were prevented from accessing medical assistance in dying (MAiD) following their loss of decision-making capacity while awaiting MAiD. The changes introduced with Bill C-7 continue to limit access to patients who did not enter a waiver of final consent agreement with their healthcare providers. Little is known about the experiences with patients’ loss of capacity to consent and subsequent ineligibility for MAiD. Understanding healthcare providers’ experiences has important implications for improving end-of-life care for those with capacity-limiting conditions. Purpose: To explore Canadian healthcare providers’ experiences with end-of-life of eligible patients who became ineligible for MAiD due to their loss of decision-making capacity to consent and the relational influences on their experiences prior to the implementation of Bill C-7 in Canada. Method: A critical qualitative methodology and a feminist ethics theoretical lens guided this study. A voice-centred relational approach that allowed an in-depth exploration of how power, relationality and moral agency influenced participants’ experiences was used for data analysis. Data consisted of semi-structured interviews with 30 healthcare providers. Findings: The analysis resulted in the following four main themes and corresponding subthemes: (1) identifying factors that may result in ineligibility for MAiD due to capacity loss; (2) maintaining eligibility required to access MAiD; (3) preparing for an alternative end-of-life; (4) experiencing patients’ capacity loss. Discussion: This study highlights that while MAiD is legally available to eligible Canadians, access to MAiD and care for eligible patients who were unable to access MAiD due to their loss of decision-making varied based on the geographical locations and access to willing MAiD and end-of-life care providers. The availability of high-quality palliative care for patients throughout the MAiD process, including following the loss of capacity to consent and subsequent ineligibility, would improve the end-of-life experience for all those involved. The need to establish a systematic approach to prepare and care for patients and their families following the patients’ loss of capacity and subsequent ineligibility for MAiD is also identified.
Circ_0003570 Suppresses the progression of hepatocellular carcinoma through miR-182-5p/STARD13 regulatory axis
Authors: Zhang Xu , Chen Wenwen , Guo Dan , Li Yarui , Zhao Yan , Ren Mudan , Lu Guifang , Lu Xinlan , He Shuixiang 
Published: October 2022

Abstract
Background
Emerging evidence have revealed that circRNAs exert important biological effects in the development and progression of various diseases, including cancer. Our study aimed to elaborated the biological effects of hsa-circ_0003570 in hepatocellular carcinoma (HCC) development at the molecular level.

Results
The results of functional experiments showed that knockdown of circ_0003570 induced HCC cell growth, migration and invasion, whereas overexpression of circ_0003570 presented the opposite effects. In vivo experiments, xenograft tumors grown from circ-overexpressed cells had smaller tumor volume and weight than the control group. Further investigations suggested that circ_0003570 may function as a competing endogenous RNA via competitively binding miR-182-5p and thereby regulating the repression of downstream target gene STARD13, which were demonstrated by dual luciferase reporter assay and functional rescued experiments.

Conclusions
Taken together, circ_0003570 suppresses the development of HCC by modulating miR-182-5p/STARD13 axis.
DENSEN: a convolutional neural network for estimating chronological ages from panoramic radiographs
Authors: Wang Xuedong , Liu Yanle , Miao Xinyao , Chen Yin , Cao Xiao , Zhang Yuchen , Li Shuaicheng , Zhou Qin 
Published: October 2022

Abstract
Background
Age estimation from panoramic radiographs is a fundamental task in forensic sciences. Previous age assessment studies mainly focused on juvenile rather than elderly populations (> 25 years old). Most proposed studies were statistical or scoring-based, requiring wet-lab experiments and professional skills, and suffering from low reliability.

Result
Based on Soft Stagewise Regression Network (SSR-Net), we developed DENSEN to estimate the chronological age for both juvenile and older adults, based on their orthopantomograms (OPTs, also known as orthopantomographs, pantomograms, or panoramic radiographs). We collected 1903 clinical panoramic radiographs of individuals between 3 and 85 years old to train and validate the model. We evaluated the model by the mean absolute error (MAE) between the estimated age and ground truth. For different age groups, 3–11 (children), 12–18 (teens), 19–25 (young adults), and 25+ (adults), DENSEN produced MAEs as 0.6885, 0.7615, 1.3502, and 2.8770, respectively. Our results imply that the model works in situations where genders are unknown. Moreover, DENSEN has lower errors for the adult group (> 25 years) than other methods. The proposed model is memory compact, consuming about 1.0 MB of memory overhead.

Conclusions
We introduced a novel deep learning approach DENSEN to estimate a subject’s age from a panoramic radiograph for the first time. Our approach required less laboratory work compared with existing methods. The package we developed is an open-source tool and applies to all different age groups.
Sentinel lymph node mapping with superparamagnetic iron oxide for melanoma: a pilot study in healthy participants to establish an optimal MRI workflow protocol
Authors: Aldenhoven Loeki , Frotscher Caroline , Körver-Steeman Rachelle , Martens Milou H. , Kuburic Damir , Janssen Alfred , Beets Geerard L. , van Bastelaar James 
Published: October 2022

Abstract
Background
Current pre-operative Sentinel Lymph Node (SLN) mapping using dual tracing is associated with drawbacks (radiation exposure, logistic challenges). Superparamagnetic iron oxide (SPIO) is a non-inferior alternative for SLN mapping in breast cancer patients. Limited research has been performed on SPIO use and pre-operative MRI in melanoma patients to identify SLNs.

Methods
Healthy participants underwent MRI-scanning pre- and post SPIO-injection during 20 min. Workflow protocols varied in dosage, massage duration, route of administration and injection sites. The first lymph node showing a susceptibility artefact caused by SPIO accumulation was considered as SLN.

Results
Artefacts were identified in 5/6 participants. Two participants received a 0.5 ml subcutaneous injection and 30-s massage, of which one showed an artefact after one hour. Four participants received a 1.0 ml intracutaneous injection and two-minute massage, leading to artefacts in all participants. All SLNs were observed within five minutes, except after lower limb injection (30 min).

Conclusion
SPIO and pre-operative MRI-scanning seems to be a promising alternative for SLN visualization in melanoma patients. An intracutaneous injection of 1.0 ml SPIO tracer, followed by a two-minute massage seems to be the most effective technique, simplifying the pre-operative pathway. Result will be used in a larger prospective study with melanoma patients.

Trial registration
ClinicalTrials.gov (NCT05054062) – September 9, 2021.
Overall survival of individuals with metastatic cancer in Sweden: a nationwide study
Authors: Bütepage Greta , Carlqvist Peter , Jacob Johanna , Toft Hornemann Asbjørn , Vertuani Simona 
Published: October 2022

Abstract
Aims
Consistent improvements for overall survival (OS) have been reported for individuals with metastatic cancer. Swedish population-based registers allow national coverage and long follow-up time. The aim of this study was to estimate and explore long-term OS of individuals diagnosed with metastatic cancer using Swedish nationwide health registers.

Methods
Individuals with metastatic breast (MBC), non-small cell lung (MNSCLC), ovary (MOC) or colorectal cancer (MCRC) or metastatic malignant melanoma (MMM) were identified in the Swedish national cancer register and national patient registers. Survival was estimated and stratified by available variables. Potential cure fractions were estimated using mixture cure models.

Results
In total, approximately 69,000 individuals were identified. The most common cancers were MCRC (36.2%) and MNSCLC (29.5%). Men were more frequently diagnosed with MNSCLC, MCRC, and MMM compared to women. Except for MOC, about 50% of individuals were 70 years or older at diagnosis. Throughout the study period survival differed across cancers. The longest median OS was observed for individuals with MOC and MBC. At 10 years of follow-up, the survival curves flatten at a survival rate of approximately 10% for all cancers except MNSCLC. The youngest age groups had the longest median OS. Increased survival was also observed for individuals diagnosed in 2015 and 2018 compared to individuals diagnosed during earlier years. The estimated cure fractions were 4% for MBC, 1.5% for MNSCLC, 6.8% for MCRC, 8.6% for MOC and MMM.

Conclusions
Long-term survival has been assessed across all indications except for NSCLC.. The findings may be relevant for healthcare planning to meet the needs of future patients and potential long-term survivors.
Development of a community-based COVID-19 intervention in rural Ghana: a document analysis
Authors: Frimpong Shadrack Osei , Seidu Moro , Hilton Sam Kris , Ransome Yusuf , Paintsil Elijah , Talbert-Slagle Kristina , Dorcoo-Attipoe Sharon , Brayne Carol 
Published: October 2022

Abstract
Background
The COVID-19 pandemic has caused the loss of millions of lives and economic breakdowns in many countries across the globe. Despite the limited availability of vaccines and the challenges of poor health infrastructure, few interventions have been developed and implemented for those who live in rural areas, particularly in sub-Saharan Africa. In response, Cocoa360, a global health nonprofit in rural Ghana designed an intervention called Cocoa360’s COVID-19 Preparedness and Outbreak Prevention Plan (CoCoPOPP). This paper aimed to examine the extent to which CoCoPOPP’s design aligned with the Promoting Action on Research Implementation in Health Services (PARIHS) framework.

Methods
We reviewed documents influencing CoCoPOPP’s design between March and June 2021. A total of 11 documents were identified for analysis. Using the Promoting Action on Research Implementation in Health Services (PARIHS) framework as a guide, thematic analysis was done to analyze the extracted data.

Results
Overall, CoCoPOPP’s design aligned with the evidence, context, and facilitation domains of the PARIHS framework. It positioned CoCoPOPP as an intervention that considered the unique context of a rural Ghanaian setting. It was guided by robust and high-quality published and non-published evidence and engaged external and internal stakeholders during its implementation. CoCoPOPP’s context-dependent nature positions it for potential replication in sub-Saharan Africa’s rural communities with similar farming contexts. Specific areas that were less well and/or not addressed were the unintended negative consequences of community engagement, the absence of primary data in the guiding evidence, and the lack of a facilitation continuum coupled with the role of power during the facilitation process.

Conclusion
CoCoPOPP, Cocoa360’s response to the COVID-19 pandemic in rural Ghana, is an evidence-driven, context-dependent public health intervention that has been designed to reduce COVID-19 infections and prevent potential deaths. This study underscores the importance of considering the unique community and cultural contexts, employing evidence, and engaging local and external actors as facilitators when designing interventions to respond to global health pandemics.
Restoration and maintenance of segment lordosis in oblique lumbar interbody fusion
Authors: Gong Ke , Lin Yang , Wang Zhibin , Li Feng , Xiong Wei 
Published: October 2022

Abstract
Purpose
Restoration of the segment lordosis angle (SLA) can effectively reduce the risk of adjacent segment degeneration. This study aimed to perform a comprehensive multifactor analysis of the risk factors affecting restoration and maintenance of the SLA in oblique lumbar interbody fusion (OLIF).

Methods
Seventy-three patients (93 segments) who underwent OLIF with posterior pedicle screw fixation due to lumbar degenerative disease between January 2015 and December 2019 were included. Radiographic parameters including the middle disc height (MDH), segment lordosis angle (SLA), cage center point ratio (CPR), cage subsidence, and L1 CT Hounsfield Unit (HU) were measured.

Results
The postoperative SLA increased from 3.5° to 8.7°, and decreased to 6.7° at the last follow-up. Multivariate analysis showed that preoperative SLA, CPR and cage subsidence were significantly correlated with SLA restoration. The significant correlations were between restoration of SLA with pre-operative SLA (r=-0.575, adjusted R2 = 0.323, P < 0.01) and between SLA restoration and CPR (r = 0.526, adjusted R2 = 0.268, P < 0.01). Cage subsidence was found in 12.9% (12/93) of segments and was the main factor affecting SLA loss (4.2 ± 1.0° versus 1.7 ± 2.1°, P < 0.01). Logistic regression analysis showed that CPR < 50%, L1 CT HU < 110 and cage height > preoperative MDH were risk factors for cage subsidence. Cages placed anteriorly (CPR ≥ 50%) showed a large SLA increase and lower incidence of cage subsidence than those placed posteriorly (5.9 ± 3.9° versus 4.2 ± 3.2°, P < 0.05; 1.8% versus 28.9%, P < 0.05, respectively).

Conclusion
SLA restoration is dependent on preoperative SLA, cage subsidence and cage position in OLIF. Cage position is the key determinant of SLA restoration and placement of the cage at the anterior position (CPR ≥ 50%) can achieve better restoration of the SLA and reduce the incidence of cage subsidence.
Pingyin rose essential oil alleviates LPS-Induced inflammation in RAW 264.7 cells via the NF-κB pathway: an integrated in vitro and network pharmacology analysis
Authors: Raka Rifat Nowshin , Zhiqian Ding , Yue Yuan , Luchang Qiao , Suyeon Park , Junsong Xiao , Hua Wu 
Published: October 2022

Abstract
Background
Rosa rugosa cv. Plena, a cultivar of Rosa rugosa, has a history of more than 1300 years of application in both medicine and food in China. The essential oil of Rosa rugosa cv. Plena (PREO) is one of the most frequently used additives in food, cosmetics and aromatherapy. PREO exhibits some anti-inflammation, antioxidant and nerve alleviating effects. However, the mechanisms behind these effects are still unclear.

Methods
The composition of PREO was determined by GC‒MS. Network pharmacology was performed to predict the possible compound-target network and analyze the possible targets against inflammation and oxidative stress. An inflammatory immune cell model was constructed by exposing RAW 264.7 cells to LPS. A series of experiments, including biochemical assays, RT‒PCR, and western blotting, were conducted to investigate the anti-inflammatory and antioxidative effects of PREO.

Results
PREO treatment significantly (p < 0.05) alleviated inflammatory and oxidative biomarkers such as NO, ROS, and MDA and preserved SOD and CAT activities. GC‒MS analysis revealed that PREO consists of 57 compounds, mainly monoterpenoids. Network pharmacology revealed that citronellol, farnesol, ethyl octanoate, geranyl acetate, and methyl eugenol were active components interacting with several inflammatory pathway proteins. By measuring the gene and protein expression of possible targets by qRT‒PCR and western blotting, PREO anti-inflammatory responses in LPS-treated RAW 264.7 cells might be associated with the regulation of NF-κB signaling. Molecular docking showed that PREO components can interact with different proteins involved in the NF-κB pathway.

Conclusion
The integrated study of molecular analysis and network pharmacology suggested that PREO might be a potential anti-inflammatory agent to treat inflammation and oxidative stress.
Creating an online educational intervention to improve knowledge about systematic reviews among healthcare workers: mixed-methods pilot study
Authors: Krnic Martinic Marina , Malisa Snjezana , Aranza Diana , Civljak Marta , Marušić Ana , Sapunar Damir , Poklepovic Pericic Tina , Buljan Ivan , Tokalic Ruzica , Cavic Dalibor , Puljak Livia 
Published: October 2022

Abstract
Background
Lack of knowledge about systematic reviews (SRs) could prevent individual healthcare workers (HCWs) from using SRs as a source of information in their clinical practice or discourage them from participating in such research. In this study, we aimed to explore in-depth the opinion of a sample of HCWs about the newly created online educational intervention designed to improve knowledge about SRs.

Methods
We created a brief online educational intervention on SRs, consisting of 11 textual modules. We evaluated it among practicing HCWs who graduated from a university-level health sciences program using a mixed-methods pilot study that consisted of pre- and post-intervention questionnaires and qualitative evaluation via semi-structured interviews. We assessed participants’ knowledge about SR methodology before and after the intervention, and compared the responses. We sought their opinions about the characteristics of SRs. Also, the participants were presented with four scientific abstracts, where they were asked to distinguish whether those abstracts presented summaries of a systematic or a non-systematic review.

Results
Twelve participants took part in the study. In the pilot study, the participants’ knowledge about SRs was improved after the intervention compared to the baseline. Participants provided positive feedback regarding the educational intervention. Suggestions to improve the educational intervention were to provide more details about the forest plot, add more digital content or images, provide more details about the methodological steps of an SR, add descriptions about practical applications of SRs and provide links to additional educational materials. The participants suggested that HCWs could be motivated to take part in such an education if it is offered as continuing medical education (CME) course or credit for academic/career advancement.

Conclusion
HCWs provided positive feedback about the newly designed online educational intervention on SRs; they considered it an appropriate tool for learning about SRs and resulted in increased knowledge about SRs. In addition, participants gave suggestions for improving education, which can be used to tailor the education for end-users. In future studies, it would be useful to examine the effectiveness of the modified educational intervention on increasing knowledge in a larger sample and in the form of a randomized controlled trial.
Do in-service training materials for midwifery care providers in sub-Saharan Africa meet international competency standards? A scoping review 2000–2020
Authors: Welsh Joanne , Hounkpatin Hashim , Gross Mechthild M. , Hanson Claudia , Moller Ann-Beth 
Published: October 2022

Abstract
Background
Levels of maternal and neonatal mortality remain high in sub-Saharan Africa, with an estimated 66% of global maternal deaths occurring in this region. Many deaths are linked to poor quality of care, which in turn has been linked to gaps in pre-service training programmes for midwifery care providers. In-service training packages have been developed and implemented across sub-Saharan Africa in an attempt to overcome the shortfalls in pre-service training. This scoping review has aimed to summarize in-service training materials used in sub-Saharan Africa for midwifery care providers between 2000 and 2020 and mapped their content to the International Confederation of Midwives (ICM) Essential Competencies for Midwifery Practice.

Methods
Searches were conducted for the years 2000–2020 in Cumulative Index of Nursing and Allied Health Literature, PubMed/MEDLINE, Social Science Citation Index, African Index Medicus and Google Scholar. A manual search of reference lists from identified studies and a search of grey literature from international organizations was also performed. Identified in-service training materials that were accessible freely on-line were mapped to the ICM Essential Competencies for midwifery practice.

Results
The database searches identified 1884 articles after removing duplicates. After applying exclusion criteria, 87 articles were identified for data extraction. During data extraction, a further 66 articles were excluded, leaving 21 articles to be included in the review. From these 21 articles, six different training materials were identified. The grey literature yielded 35 training materials, bringing the total number of in-service training materials that were reviewed to 41. Identified in-service training materials mainly focused on emergency obstetric care in a limited number of sub-Saharan Africa countries. Results also indicate that a significant number of in-service training materials are not readily and/or freely accessible. However, the content of in-service training materials largely met the ICM Essential Competencies, with gaps noted in the aspect of woman-centred care and shared decision making.

Conclusion
To reduce maternal and newborn morbidity and mortality midwifery care providers should have access to evidence-based in-service training materials that include antenatal care and routine intrapartum care, and places women at the centre of their care as shared decision makers.