bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imp is required for timely exit from quiescence in Drosophila type II neuroblasts
Authors: Munroe Jordan A. , Syed Mubarak H. , Doe Chris Q. 
Published: July 2022

AbstractStem cells must balance proliferation and quiescence, with excess proliferation favoring tumor formation, and premature quiescence preventing proper organogenesis. Drosophila brain neuroblasts are a model for investigating neural stem cell entry and exit from quiescence. Neuroblasts begin proliferating during embryogenesis, enter quiescence prior to larval hatching, and resume proliferation 12-30h after larval hatching. Here we focus on the mechanism used to exit quiescence, focusing on the “type II” neuroblasts. There are 16 type II neuroblasts in the brain, and they undergo the same cycle of embryonic proliferation, quiescence, and proliferation as do most other brain neuroblasts. We focus on type II neuroblasts due to their similar lineage as outer radial glia in primates (both have extended lineages with intermediate neural progenitors) and because of the availability of specific markers for type II neuroblasts and their progeny. Here we characterize the role of Insulin-like growth factor II mRNA-binding protein (Imp) in type II neuroblast proliferation and quiescence. Imp has previously been shown to promote proliferation in type II neuroblasts, in part by acting antagonistically to another RNA-binding protein called Syncrip (Syp). Here we show that reducing Imp levels delays neuroblast exit from quiescence in type II neuroblasts, acting independently of Syp, with Syp levels remaining low in both quiescent and newly proliferating type II neuroblasts. We conclude that Imp promotes exit from quiescence, a function closely related to its known role in promoting neuroblast proliferation.
Toward sustainable jet fuels: bioconversion of cellulose into isoprenoid biojet candidates using rumen bacteria and non-conventional yeast
Authors: Walls Laura E. , Otoupal Peter , Ledesma-Amaro Rodrigo , Velasquez-Orta Sharon B. , Gladden John M. , Rios-Solis Leonardo 
Published: July 2022

AbstractIn this study, organic acids were demonstrated as a promising carbon source for bisabolene production by the non-conventional yeast, Rhodosporidium toruloides, at microscale with a maximum titre of 1055 ± 7 mg/L. A 125-fold scale-up of the optimal process, enhanced bisabolene titres 2.5-fold to 2606 mg/L. Implementation of a pH controlled organic acid feeding strategy at this scale lead to a further threefold improvement in bisabolene titre to 7758 mg/L, the highest reported microbial titre. Finally, a proof-of-concept sequential bioreactor approach was investigated. Firstly, the cellulolytic bacterium Ruminococcus flavefaciens was employed to ferment cellulose, yielding 4.2 g/L of organic acids. R. toruloides was subsequently cultivated in the resulting supernatant, producing 318 ± 22 mg/L of bisabolene. This highlights the feasibility of a sequential bioprocess for the bioconversion of cellulose, into biojet fuel candidates. Future work will focus on enhancing organic acid yields and the use of real lignocellulosic feedstocks to further enhance bisabolene production.Graphical Abstract
Evolution and spread of multi-adapted pathogens in a spatially heterogeneous environment
Authors: Griette Quentin , Alfaro Matthieu , Raoul Gaël , Gandon Sylvain 
Published: July 2022

AbstractThe emergence and the spread of multi-adapted pathogens is often viewed as a slow process resulting from the incremental accumulation of single adaptations. In bacteria, for instance, multidrug resistance to antibiotics may result from the sequential acquisition of single drug resistance to different antibiotics. In phytopathogens, the ability to infect different resistant varieties of crops may also result from the accumulation of distinct virulence genes. Here we use a general epidemiological model to analyse the evolution of pathogen adaptations throughout an epidemic spreading in a heterogeneous host population where selection varies periodically in space. This spatially heterogeneous selection may result from the use of different drugs, different vaccines or different crop varieties in agriculture. We study both the transient evolution of pathogen adaptation at the front of the epidemic and the long-term evolution far behind the epidemic front. We identify five different types of epidemic profiles that may arise from different combinations of spatial heterogeneity and the cost of multi-adaptation. In particular, we show that multi-adaptation can drive epidemic spread, while the evolution of single-adaptation may only occur in a second phase, when the pathogen specializes on local selective pressures. Indeed, a generalist pathogen with multiple adaptations can outpace the spread of a coalition of specialist pathogens when selection varies frequently in space. This result is amplified in finite host populations because demographic stochasticty can lead to the extinction of maladapted pathogens specialised to a local selective pressure. Our work has important implications for the management of multiple drugs and vaccines against pathogens but also for the optimal deployment of resistant varieties in agriculture.
GRMI4.0: a guide for representing and modeling Industry 4.0 business processes
Authors: Mosser Jérémie , Pellerin Robert , Bourgault Mario , Danjou Christophe , Perrier Nathalie 
Published: July 2022

PurposeThe purpose of this paper is to propose a new business process representation adapted to the needs of Industry 4.0 to facilitate the implementation of technological solutions in the construction sector.Design/methodology/approachThis work is based on the Design Research Methodology approach and includes four phases: (1) a literature review on the main business process modeling standards and their ability to take into account the specificities of Industry 4.0; (2) the identification of the attributes to be considered to model Industry 4.0 processes; (3) the development of a mapping model for Industry 4.0; and (4) the validation of the model using a case study from the construction sector.FindingsTo the authors’ knowledge, current business process modeling standards do not effectively represent business processes in the context of Industry 4.0.Originality/valueThe proposed model can represent not only the 4.0 solutions that can be implemented in the construction sector, particularly from a technology and data perspective but also measures, with the help of performance indicators, the impacts of successive process changes in terms of skills, cost and time for a true 4.0 transformation.
Transforming unstructured digital clinical notes for improved health literacy
Authors: Doppalapudi Shreyesh , Wang Tingyan , Qiu Robin 
Published: July 2022

PurposeClinical notes typically contain medical jargons and specialized words and phrases that are complicated and technical to most people, which is one of the most challenging obstacles in health information dissemination to consumers by healthcare providers. The authors aim to investigate how to leverage machine learning techniques to transform clinical notes of interest into understandable expressions.Design/methodology/approachThe authors propose a natural language processing pipeline that is capable of extracting relevant information from long unstructured clinical notes and simplifying lexicons by replacing medical jargons and technical terms. Particularly, the authors develop an unsupervised keywords matching method to extract relevant information from clinical notes. To automatically evaluate completeness of the extracted information, the authors perform a multi-label classification task on the relevant texts. To simplify lexicons in the relevant text, the authors identify complex words using a sequence labeler and leverage transformer models to generate candidate words for substitution. The authors validate the proposed pipeline using 58,167 discharge summaries from critical care services.FindingsThe results show that the proposed pipeline can identify relevant information with high completeness and simplify complex expressions in clinical notes so that the converted notes have a high level of readability but a low degree of meaning change.Social implicationsThe proposed pipeline can help healthcare consumers well understand their medical information and therefore strengthen communications between healthcare providers and consumers for better care.Originality/valueAn innovative pipeline approach is developed to address the health literacy problem confronted by healthcare providers and consumers in the ongoing digital transformation process in the healthcare industry.
An opportunity to build back better? COVID-19 and environmental sustainability of Australian events
Authors: Hutte Gerard Jan , Markwell Kevin , Wilson Erica 
Published: July 2022

PurposeThis study explores (1) the impacts of COVID-19 on the environmental sustainability of Australian events; (2) the measures undertaken to minimise the impacts of COVID-19 on environmental sustainability; (3) the key impediments to incorporating COVID-Safe measures in an environmentally sustainable way; and (4) the expected long-term impact of the COVID-19 situation on the development of the environmental sustainability of the Australian events industry.Design/methodology/approachThe study follows a qualitative approach by undertaking semi-structured interviews with (N = 23) event industry professionals. The data collection phase took place between November 2020 and May 2021 and the study was completed in February 2022.FindingsAdverse environmental impacts included increased waste output and the stagnation of planned or existing environmental practices. The study reveals positive effects such as reduced carbon emission outputs and increased environmental awareness of event participants. Financial costs, time pressure, uncertainty and sourcing issues are significant impediments to organising events in an environmentally sustainable manner during a global pandemic situation.Practical implicationsUnderstanding how COVID-19 impacts the environmental sustainability of events will help the industry to preserve previous progress made, overcome similar obstacles during future crises, and capitalise on opportunities for positive environmental change.Originality/valueThis is the first study to examine the impact of the COVID-19 pandemic on the environmental sustainability practices of Australian events.
Why should I let them know? Effects of workplace incivility and cynicism on employee knowledge hiding behavior under the control of ethical leadership
Authors: Anand Amitabh , Agarwal Upasna A. , Offergelt Florian 
Published: July 2022

PurposeThe purpose of this study is to examine if individual cynicism mediates the relationship between workplace incivility (WI) and knowledge hiding (KH). Additionally, it is examined whether ethical leadership has a moderating role regarding the effect of WI on KH.Design/methodology/approachThe authors conducted two multi-wave studies, each with two times of data collection. Study 1 included data from 390 members of 30 teams from knowledge-intensive organizations. In study 2, data was collected from 437 software professionals working in diverse organizations.FindingsResults showed that cynicism mediated the impact of WI on KH. Furthermore, the positive direct and indirect effect of WI on KH was shown to be moderated by perceived ethical leadership such that high ethical leadership mitigates the effects.Originality/valueThis study extends the research on knowledge management by explaining a new mechanism and framework in which KH can occur and provides important practical recommendations for human resource managers to contribute to the overall organization's success.
Vibrations of a vertical 90° pipe bend under two-phase flow conditions
Authors: Shah Reza Shah Danial , Rasani Mohammad Rasidi 
Published: July 2022

PurposeA simulation framework that includes a finite element analysis (FEA) and computational fluid dynamics (CFD) model is generated to study the effect of unstable two-phase flow-induced vibrations at a vertical 90° pipe bend. The corresponding fluid-structure interaction (FSI) of an unstable flow may pose danger to the piping structure. This paper intends to discuss this interaction.Design/methodology/approachFour cases of flows under the slug flow and churn flow regimes were investigated. The flow regimes vary in superficial gas velocities with velocities from 0.978 m/s to 9.04 m/s, while the superficial liquid velocity is kept constant at 0.61 m/s. The pipe model consists of an internal diameter of 0.0525 m, a bend radius of 0.0762 m, and a stainless-steel pipe structure.FindingsResults show that the average unstable void fractions increase with the superficial gas velocities, but the peak frequencies were constant at 13 Hz for three of the cases. The total displacement and von Mises stress increase with a declining rate in each subsequent case, while the RMS of von Mises stress begins to stall at superficial gas velocities between 5 m/s and 9.04 m/s. The peak frequencies of von Mises stress decrease in each subsequent case.Originality/valueThe proposed model can be used to investigate the FSI effect of unstable void fractions at pipe bends and could assist in the development of piping systems in which the use of piping elements arranged close together are unavoidable.
Influence of fire-resistant coating on the physical characteristics and residual mechanical properties of E350 steel section exposed to elevated temperature
Authors: Jaya Kumar G. , Kiran Tattukolla , Anand N. , Al-Jabri Khalifa 
Published: July 2022

PurposeMost of the industrial buildings which are designed to moderate loads are constructed using light gauge cold-formed steel (CFS) sections. Residual mechanical properties of CFS sections exposed to elevated temperature need to be investigated as it is necessary to predict the deterioration of elements to avoid failure of the structure or its elements. Also, it would be helpful to decide whether the structural elements need to be replaced or reused. The use of fire-resistant coatings in steel structures significantly reduces the cost of repairing structural elements and also the probability of collapse. This study investigates the effect of fire-resistant coating on post-fire residual mechanical properties of E350 steel grade.Design/methodology/approachIn this study, an attempt has been made to evaluate the residual mechanical properties of E350 steel. A tensile coupon test was performed for the extracted specimens from the exposed CFS section to determine the mechanical properties. Four different fire-resistant coatings were selected and the sections were coated and heated as per ISO 834 fire temperature curve in the transient state for time durations of 30 minutes (821°C), 60 minutes (925°C), 90 minutes (986°C), and 120 minutes (1,029°C). After the exposure, all the coupon specimens were cooled by either ambient conditions (natural air) or water spraying before conducting the tension test on these specimens.FindingsAt 30 min exposure, the reduction in yield and ultimate strength of heated specimens was about 20 and 25% for air and water-cooled specimens compared with reference specimens. Specimens coated with vermiculite and perlite exhibited higher residual mechanical property up to 60 minutes than other coated specimens for both cooling conditions. Generally, water-cooled specimens had shown higher strength loss than air-cooled specimens. Specimens coated with vermiculite and perlite showed an excellent performance than other specimens coated with zinc and gypsum for all heating durations.Originality/valueAs CFS structures are widely used in construction practices, it is crucial to study the mechanical properties of CFS under post-fire conditions. This investigation provides detailed information about the physical and mechanical characteristics of E350 steel coated with different types of fire protection materials after exposure to elevated temperatures. An attempt has been made to improve the residual properties of CFS using the appropriate coatings. The outcome of the present study may enable the practicing engineers to select the appropriate coating for protecting and enhancing the service life of CFS structures under extreme fire conditions.
An interdisciplinary reflective approach to promote architectural design pedagogy: animating basic design principles by music visualizer
Authors: Abusafieh Shaden Fakhri 
Published: July 2022

PurposeThe study investigates the effectiveness of an adaptive reflective framework that shifts the learning process toward a student-centered approach within an interdisciplinary learning environment. It aims to promote the learning process within an interdisciplinary learning environment that could promote the students’ design competencies.Design/methodology/approachThe experiment was conducted at Basic Design studio, investigating three concepts of basic design principles: harmony, repetition and rhythm. A total of 80 first-year architectural students were enrolled in this study and placed into two equal groups: the “control group” received the traditional learning method and in contrast, the “experimental group” received an interdisciplinary reflective learning method using music as a relevant discipline.FindingsThe results showed that utilizing “Music Animation Machine” in the learning process significantly promoted students’ cognitive skills, engagement and design competencies. In addition, there was obvious evidence of excellent progress in learning basic design principles using the proposed reflective approach within a student-centered learning environment.Originality/valueMany researchers focus on the importance of using music as a design tool. However, there is a crucial demand for investigating it as a learning tool. This research raised music effectiveness in the learning process of design principles. Thus, it incites to test more disciplines interconnected with architectural design. Other researchers could utilize this approach to ensure its effect on enhancing design competencies in the basic design and other architectural design courses.
Can disease resistance evolve independently at different ages? Genetic variation in age‐dependent resistance to disease in three wild plant species
Authors: Bruns Emily B. , Hood Michael E. , Antonovics Janis , Ballister Indigo H. , Troy Sarah E. , Cho Jae‐Hoon 
Published: July 2022

Abstract

Juveniles are typically less resistant (more susceptible) to infectious disease than adults, and this difference in susceptibility can help fuel the spread of pathogens in age‐structured populations. However, evolutionary explanations for this variation in resistance across age remain to be tested.

One hypothesis is that natural selection has optimized resistance to peak at ages where disease exposure is greatest. A central assumption of this hypothesis is that hosts have the capacity to evolve resistance independently at different ages. This would mean that host populations have (a) standing genetic variation in resistance at both juvenile and adult stages, and (b) that this variation is not strongly correlated between age classes so that selection acting at one age does not produce a correlated response at the other age.

Here we evaluated the capacity of three wild plant species (Silene latifolia, S. vulgaris and Dianthus pavonius) to evolve resistance to their anther‐smut pathogens (Microbotryum fungi), independently at different ages. The pathogen is pollinator transmitted, and thus exposure risk is considered to be highest at the adult flowering stage.

Within each species we grew families to different ages, inoculated individuals with anther smut, and evaluated the effects of age, family and their interaction on infection.

In two of the plant species, S. latifolia and D. pavonius, resistance to smut at the juvenile stage was not correlated with resistance to smut at the adult stage. In all three species, we show there are significant age × family interaction effects, indicating that age specificity of resistance varies among the plant families.

Synthesis. These results indicate that different mechanisms likely underlie resistance at juvenile and adult stages and support the hypothesis that resistance can evolve independently in response to differing selection pressures as hosts age. Taken together our results provide new insight into the structure of genetic variation in age‐dependent resistance in three well‐studied wild host–pathogen systems.
The Commission Knocked Out Cold: Laura Serrano and the End of the Mexico City Prohibition of Women's Boxing in the 1990s
Authors: Van Bavel Marjolein 
Published: July 2022

AbstractThis article examines the conflict over the legalisation of women's boxing in Mexico City in the 1990s. In 1995, Laura Serrano's Women's International Boxing Federation world boxing title put pressure on the legal system that had banned women from professional boxing in the Mexican capital since 1946. As the visibility of women's boxing grew in Mexico, Serrano publicly fought to end the ban in her home city. The Mexico City Boxing Commission's moral arguments and medical discourses about the female body became increasingly untenable as politics of gender equality won in importance. Using a range of sources, including Mexican newspapers and magazines, government gazettes, congress proceedings, and an autobiographical text by Serrano, this article illustrates the interplay of gender ideologies and institutional structures during an important period in Mexican political history. After seven decades of uninterrupted Institutional Revolutionary Party rule, power of the Mexican capital shifted to the Party of the Democratic Revolution (PRD) when Cuauhtémoc Cárdenas became the city's first elected governor in 1997. Although the PRD politically claimed the end of the prohibition in 1998, the shift in power cost Serrano the best paid boxing event of her career. It took another legal reform that outlawed discrimination in sports to force the Commission to finally regulate women's boxing in 1999.