bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ammoniacal leaching behavior and regularity of zinc ash
Authors: Long Hailin , Tan Xuezhi , Ni Shufang , Ma Aiyuan , Li Shiwei , Zhu Deqing 
Published: December 2022

AbstractIn this work, a new hydrometallurgical process was developed to treat zinc ash produced from the hot galvanizing industry. The theoretical analysis shows the feasibility of dissolving zinc ash in the NH3–NH4Cl–H2O system, and the dissolution products are predominantly composed of Zn (NH3)42+. The impacts of different experimental conditions were examined, and the leaching ratio of zinc was as high as 96.4% under the conditions of NH3/NH4+ratio of 1:1, liquid/solid of 9:1, total ammonia concentration of 8 mol/L and the stirring speed of 250 rpm at 313 K for 120 min. The kinetics of the leaching process were investigated and the calculated apparent activation energy was approximately 4.69 kJ/mol, which indicated that the zinc ash leaching process was controlled by diffusion-controlled. As revealed by the determination of impurity ions, on one hand, there were fewer impurities in the leaching solution, and the concentrations of Fe2+and Pb2+in solution are less than 0.02 mg/L and 0.05 mg/L respectively; on the other hand, there was no need for further impurity removal in this process. The proposed process has a certain application value in treating zinc ash.
Resilience of U.S. Cattle and Beef Sectors: Lessons from COVID-19
Authors: Hayes Dermot , Jacobs Keri , Schulz Lee , Crespi John 
Published: December 2022

Abstract
The upheaval wrought on the U.S. beef industry by the global COVID-19 pandemic carried with it several lessons that might help improve resiliency should there be a reoccurrence. First, the futures market for fed cattle fell well before cash prices, which sent a signal to market cattle early, and those who did so benefited. Second, the decline in futures anticipated the closure of slaughter plants and provided an opportunity to purchase and store beef primals in anticipation of future scarcity. Third, the beef industry has ways of slowing or stopping the pipeline of animals destined for feed yards and can “store” these animals in background feeding facilities or on pasture or rangeland. Producers who waited to sell feeder cattle benefited from higher feeder cattle prices once the processing facilities reopened. Fourth, cow slaughter plants responded to the pandemic and subsequent scarcity of labor much better than large fed-cattle plants. Cow plants are not as sophisticated and complex as fed-cattle plants. This relative simplicity may help explain the superior performance of these plants during the crisis. Sixth, the academic work on the value of building smaller plants as a response against concentration provides mixed results—these plants require more labor per animal and can be even more susceptible to labor scarcity. Seventh, the observed increase in boxed beef prices, even as fed cattle prices fell, demonstrates the risk-mitigating impact of producer ownership of downstream activities in the value chain.
Grating index difference (GID) and order based distributed feedback laser effects on coarse wavelength division multiplexing optical fiber systems
Authors: Rashed Ahmed Nabih Zaki , Altahan Baraa Riyadh , Manasavenna Thaticharla , Ahammad S. K. Hasane , Priya P. Poorna , Krishna M. Rama , Hossain Md. Amzad , Sorathiya Vishal , Smirani Lassaad K. , Said Said Mohammed 
Published: December 2022

Abstract
The study has outlined grating index difference (GID) and grating order based distributed feedback laser effects on coarse wavelength division multiplexing optical fiber systems. Signal amplitude level (SPL), noise signal level are measured accurately based on various grating order of distributed feedback laser. Max. signal power (MSP), noise signal power (NSP) are also measured along the variations of frequency spectrum related to spectral wavelength and bit period time versus GID variations. The optimum signal power level and minimum noise power level, maximum SPL, minimum SPL are achieved with 0.1% GID and grating order of unity.
Canagliflozin: A review with specific focus on analytical methods in biological matrices and pharmaceuticals
Authors: Azhakesan Ajitha , Kuppusamy Sujatha 
Published: December 2022

Abstract
Sodium-glucose transporter 2 inhibitor emerges as the latest group of oral hypoglycemic agents, which shows insulin-independent pathology and provides an upper hand to enhance renal glucose elimination. Canagliflozin (CGN) was the number one drug, approved by FDA on 29th March 2013 for the treatment of type 2 diabetes mellitus. By totting up to its glucose-lowering effects, it exhibits beneficial effects on the heart and potentially on the kidneys. The study aims to summarize various analytical techniques, such as chromatography, spectrophotometry, and hyphenated techniques, such as Liquid chromatography with tandem mass spectrometry (LC-MS/MS) and Ultra performance liquid chromatography with tandem mass spectrometer (UPLC-MS) for the analysis of CGN. In the proposed work, we have reviewed various analytical methods reported for the estimation of CGN in biological matrices and Pharmaceuticals from various databases like ScienceDirect, Springer, PubMed, Scopus, Taylor & Francis, and Web of Science for the estimation of CGN. Various analytical methods adapted were high-performance liquid chromatography, UPLC, LC-MS/MS, high-performance thin-layer liquid chromatography, Fourier-transform infrared spectroscopy, spectrofluorimetry, and UV spectrophotometry. This current review presented the determination of CGN using various analytical techniques and biological matrices either in single or in combination with other hypoglycemic agents, as per International Conference on Harmonization guidelines. Further, some future trends that can be integrated were also suggested.
Nonlinear curve equations maintaining constant normal accelerations with drag induced tangential decelerations
Authors: Pakdemirli Mehmet , Yıldız Volkan 
Published: December 2022

Abstract
A nonlinear curve equation is derived for a vehicle exposed to drag force only. At each point on the curve, the vehicle maintains constant normal acceleration component. The resulting curve equation is a highly nonlinear third order ordinary differential equation. By defining dimensionless coordinates, the equation is cast into a non-dimensional form and a special path parameter is defined. Two different perturbation type solutions as well as a series solution are constructed as approximations to the curves. The three approximate solutions are contrasted with the numerical solution of the problem. The validity range of the approximate solutions is discussed. The curves may be used in determining the routes of land, marine and aerial vehicles.
Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions
Authors: Mahoney-Crane Casey L. , Viswanathan Megha , Russell Dreson , Curtiss Rachel A.C. , Freire Jennifer , Bobba Sai Sumedha , Coyle Sean D. , Kandebo Monika , Yao Lihang , Wan Bang-Lin , Hatcher Nathan G. , Smith Sean M. , Marcus Jacob N. , Volpicelli-Daley Laura A. 
Published: December 2022

The most common genetic risk factor for Parkinson's disease (PD) is heterozygous mutationsGBA1, which encodes for the lysosomal enzyme, glucocerebrosidase. Reduced glucocerebrosidase activity associates with an accumulation of abnormal α-synuclein (α-syn) called Lewy pathology, which characterizes PD. PD patients heterozygous for the neuronotypic GBA1L444P mutation (GBA1+/L444P) have a 5.6-fold increased risk of cognitive impairments. In this study, we used GBA1+/L444Pmice of either sex to determine its effects on lipid metabolism, expression of synaptic proteins, behavior, and α-syn inclusion formation. At 3 months of age, GBA1+/L444Pmice demonstrated impaired contextual fear conditioning, and increased motor activity. Hippocampal levels of vGLUT1 were selectively reduced in GBA1+/L444Pmice. We show, using mass spectrometry, that GBA1L444P expression increased levels of glucosylsphingosine, but not glucosylceramide, in the brains and serum of GBA1+/L444Pmice. Templated induction of α-syn pathology in mice showed an increase in α-syn inclusion formation in the hippocampus of GBA1+/L444Pmice compared with GBA1+/+mice, but not in the cortex, or substantia nigra pars compacta. Pathologic α-syn reduced SNc dopamine neurons by 50% in both GBA1+/+and GBA1+/L444Pmice. Treatment with a GlcCer synthase inhibitor did not affect abundance of α-syn inclusions in the hippocampus or rescue dopamine neuron loss. Overall, these data suggest the importance of evaluating the contribution of elevated glucosylsphingosine to PD phenotypes. Further, our data suggest that expression of neuronotypic GBA1L444P may cause defects in the hippocampus, which may be a mechanism by which cognitive decline is more prevalent in individuals with GBA1-PD.SIGNIFICANCE STATEMENTParkinson's disease (PD) and dementia with Lewy bodies (DLB) are both pathologically characterized by abnormal α-synuclein (α-syn). MutantGBA1is a risk factor for both PD and DLB. Our data show the expression of neuronotypic GBA1L444P impairs behaviors related to hippocampal function, reduces expression of a hippocampal excitatory synaptic protein, and that the hippocampus is more susceptible to α-syn inclusion formation. Further, our data strengthen support for the importance of evaluating the contribution of glucosylsphingosine to PD phenotypes. These outcomes suggest potential mechanisms by which GBA1L444P contributes to the cognitive symptoms clinically observed in PD and DLB. Our findings also highlight the importance of glucosylsphingosine as a relevant biomarker for future therapeutics.
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons
Authors: Zong Fang‐Jiao , Min Xia , Zhang Yan , Li Yu‐Ke , Zhang Xue‐Ting , Liu Yang , He Kai‐Wen 
Published: December 2022

AbstractParvalbumin‐positive neurons (PVs) are the main class of inhibitory neurons in the mammalian central nervous system. By examining diurnal changes in synaptic and neuronal activity of PVs in the supragranular layer of the mouse primary visual cortex (V1), we found that both PV input and output are modulated in a time‐ and sleep‐dependent manner throughout the 24‐h day. We first show that PV‐evoked inhibition is stronger by the end of the light cycle (ZT12) relative to the end of the dark cycle (ZT0), which is in line with the lower inhibitory input of PV neurons at ZT12 than at ZT0. Interestingly, PV inhibitory and excitatory synaptic transmission slowly oscillate in opposite directions during the light/dark cycle. Although excitatory synapses are predominantly regulated by experience, inhibitory synapses are regulated by sleep, via acetylcholine activating M1 receptors. Consistent with synaptic regulation of PVs, we further show in vivo that spontaneous PV activity displays daily rhythm mainly determined by visual experience, which negatively correlates with the activity cycle of surrounding pyramidal neurons and the dorsal lateral geniculate nucleus‐evoked responses in V1. These findings underscore the physiological significance of PV's daily modulation.
Closing the autophagosome is easy‐PC
Authors: Fuller Devin M , Melia Thomas J 
Published: December 2022

In their recent article, Polyansky et al identify phosphatidylcholine (PC) as the most abundant lipid in the autophagosome membrane and demonstrate that eliminating de novo PC synthesis sharply impairs autophagic processing. In the absence of PC synthesis, open cup‐like structures accumulate, implicating PC as a key component in the closure of autophagosomes.
Tumor-induced osteomalacia treated with T12 tumor resection
Authors: Mancini Alyssa J , Sabet Amin , Nielsen Gunnlaugur Petur , Parker J Anthony , Schwab Joseph H , Ward Ashley , Wu Jim S , Malabanan Alan O 
Published: December 2022

Summary
Tumor-induced osteomalacia (TIO) is a rare form of osteomalacia caused by fibroblast growth factor-23 (FGF23)-secreting tumors. Most of these tumors are phosphaturic mesenchymal tumors (PMTs) typically involving soft tissue in the extremities and bone of the appendicular skeleton and cranium. We report the case of a 60-year-old woman with about 3 years of persistent bone pain and multiple fractures, initially diagnosed as osteoporosis, who was found to have hypophosphatemia with low 1,25-dihydroxyvitamin D and elevated alkaline phosphatase and inappropriately normal FGF23 consistent with TIO. Her symptoms improved with phosphate supplementation, vitamin D and calcitriol. 68Ga-DOTATATE imaging revealed a T12 vertebral body lesion confirmed on biopsy to be a PMT. She underwent resection of the PMT with resolution of TIO and increased bone density. This rare case of TIO secondary to a PMT of the thoracic spine highlights some of the common features of PMT-associated TIO and draws attention to PMT-associated TIO as a possible cause of unexplained persistent bone pain, a disease entity that often goes undiagnosed and untreated for years.

Learning points

Tumor-induced osteomalacia (TIO) is typically caused by phosphaturic mesenchymal tumors (PMTs) that are usually found in the soft tissue of the extremities and bone of the appendicular skeleton/cranium and rarely in the spine.

TIO may be misdiagnosed as osteoporosis or spondyloarthritis, and the correct diagnosis is often delayed for years. However, osteoporosis, in the absence of fracture, is not associated with bone pain.

The hallmark of TIO is hypophosphatemia with inappropriately normal or low 1,25-dihydroxyvitamin D and elevated or inappropriately normal fibroblast growth factor-23 (FGF23) levels.

In patients with unexplained persistent bone pain, a serum phosphate should be measured. Consider PMT-associated TIO as a potential cause of unexplained persistent bone pain and hypophosphatemia.

PMTs express somatostatin receptors and may be identified with 68Ga-DOTATATE imaging.

Complete surgical resection is the preferred treatment for spinal PMTs associated with TIO.
Assessing and Validating a Model of Study Completion for a Prospective Cohort of Healthy Newborns
Authors: Fusfeld Zachary H. , Goyal Neera K. , Goldstein Neal D. , Chung Esther K. 
Published: December 2022

OBJECTIVES:
To identify potentially modifiable or actionable factors related to study completion among healthy mother-infant dyads participating in prospective research.

PATIENTS/METHODS:
We conducted a secondary analysis of completion data from a prospective study on newborn jaundice in the first week of life at a tertiary-care hospital in Philadelphia, PA, from 2015 to 2019. Participation in the original study involved enrollment before newborn discharge and subsequent follow-up for a jaundice assessment between 2 and 6 days of life. For this study, our primary outcome was completion of all study procedures. Associations between predictor variables and the outcome were assessed using bivariate and multivariable analyses. We fit a predictive model of study completion using logistic regression and validated the model using 5-fold cross-validation.

RESULTS:
Of 501 mother-infant dyads enrolled in the original study, 304 completed the study. Median maternal age was 28 years and 81.8% of mothers delivered via vaginal birth. Study completion was associated with colocation of the study visit with the initial well-child visit (adjusted odds ratio [aOR], 2.99, 95% confidence interval [CI], 2.01–4.46) and provision of an alternate phone number by the participant (aOR, 1.99; 95% CI, 1.34–2.96). The cross-validated model performed similarly to our final predictive model and had an average area under the receiver operating characteristic curve of 0.67 (range, 0.59-0.72), with a sensitivity of 68% and specificity of 60%.

CONCLUSIONS:
Findings demonstrate the importance of communication and patient-centric approaches for recruitment and retention in newborn research. Future work should incorporate these approaches while continuing to evaluate study retention strategies.
Aplicación del Método Hectárea de Hábitat en compensación ambiental: El caso del Embalse Río Piedras, Costa Rica
Authors: Bonilla Fabián , Oviedo-Brenes Federico , Beneyto-Garrigos Davinia , Arévalo J.-Edgardo , Morales-Gutiérrez Lilliam , Serrano-Sandí Juan , Sasa Mahmood 
Published: December 2022

Introducción: La compensación ambiental es la alternativa final para enfrentar los impactos de proyectos de desarrollo que no pueden ser evitados, reducidos o mitigados. La compensación de hábitats pretende sustituir recursos ecológicamente equivalentes. El Método Hectárea de Hábitat se diseñó inicialmente para evaluar la equivalencia ecológica de vegetación nativa y emplea puntajes de indicadores relativos a un hábitat de referencia. La suma de estos puntajes mide la condición estructural del ambiente de manera relativa a la referencia, cuantificando el número de hectáreas necesarias para compensar la pérdida de un hábitat similar. Aunque el método no está exento de limitaciones, los valores se pueden estimar a partir de datos de campo recogidos sin ambigüedad, de forma reproducible, con menos sesgos que métodos más cualitativos. En este artículo, usamos una modificación del Método Hectárea de Hábitat para determinar el área equivalente necesaria para compensar la pérdida de hábitat en un área silvestre protegida en Costa Rica.
Metodología: Trabajamos en la Reserva Biológica Lomas de Barbudal, Pacífico norte de Costa Rica, un área silvestre protegida donde se inundarán cerca de 113 hectáreas para el Embalse de Río Piedras. En una propiedad previamente identificada como un sitio potencial de compensación, evaluamos indicadores de paisaje, suelo, estructura de la vegetación y servicios ecosistémicos; asignamos los puntajes en relación con el sitio a inundar.
Resultados: El puntaje de la condición ambiental en el sitio de compensación fue de 44,7% (±15,9%) del sitio inundado. En consecuencia, considerando la incertidumbre de nuestras mediciones, compensar la pérdida de cada hectárea requeriría entre 2.23 y 3.49 hectáreas de un ambiente similar.
Conclusión: Se necesitan entre 2.23 y 3.49 hectáreas de reemplazo, para compensar la pérdida de hábitat en el Embalse de Río Piedras.
Peningkatan kualitas Perguruan Tinggi melalui Sistem Penjamin Mutu dengan Pendekatan Total Quality Managemen
Authors: Abdurrahmansyah Abdurrahmansyah , Rismawati Ima 
Published: December 2022

Peningkatan kualitas tidak dapat dicapai tanpa jaminan kualitas yang baik. Peran lembaga penjamin mutu sebagai promotor jaminan kualitas memberikan dampak positif terhadap efektivitas peningkatan kualitas pendidikan tinggi.Tujuan penelitian ini adalah untuk menganalisis upaya-upaya peningkatan kualitas pendidikan tinggi. Motode yang digunakan adalah metode kualitatif deskriptif dengan tekhnik analisis konten. Upaya peningkatan kualitas perguruan tinggi dilakukan dengan Sistem Penjaminan Mutu Internal (SPMI) dan Sistem Penjaminan Mutu Eksternal (SPME) yang dilakukakn oleh lembaga penjamin mutu. Lembaga penjaminan mutu bertujuan untuk peningkatan, inovasi, komunikasi, motivasi dan pengawasan atau control. Penerapan manajemen mutu dilakukan dengan pendekatan Total Quality Managemen. Pendekatan TQM mengintegrasikan input, proses dan keluaran. TQM mengembangkan ukuran kinerja atau kualitas institusi seperti peringkat universitas, kepuasan mahasiswa, dan pekerjaan lulusan
The The Impact of the EU Carbon Border Adjustment Mechanism on Russian Exporters
Authors: Никифоров Владимир , Тихомиров Дмитрий 
Published: December 2022

The European Union’s commitment to achieve carbon neutrality by 2050 led EU states to develop a new legal stimulus mechanism allowing to reduce greenhouse gas emissions: the ‘Carbon Border Adjustment Mechanism’ (‘CBAM’). First introduced in July 2021, the CBAM anticipates an imposition of a special carbon import duty on companies that import certain goods and materials into the EU, with the amount of such duty calculated based on the amount of GHG emissions emitted into the atmosphere in relation to such products.
CBAM constitutes a part of today’s environmental agenda of the EU, but it obviously places additional financial burden on the shoulders of exporters, including those from Russia, for many of whom the EU has been a strategic market for a long period of time.
This article provides a summary of findings made as a result of research of available publications that addresses a potential impact of CBAM on the value and financial metrics of those Russian exporters. The authors aim to demonstrate the results of calculations of the additional burden placed on the exporters which arise from CBAM through an analysis of the structure of the export, identification of the economic sectors most affected by CBAM, calculation of a carbon export duty to be potentially paid at the border of the Eurasian Economic Union, as well as calculation of required government support for the exporters.This article further evaluates the impact of CBAM while factoring in amendments that were still not covered in comprehensive research papers at the time of publication of the particular research analysed herein. Additionally, a detailed analysis of goods exported to the EU and impacted by CBAM is conducted for the first time, including a list of significant commodity nomenclature codes which are stipulated in the relevant legislation. Finally, recommendations on potential reactions to the impositions of CBAM and their effects on the future growth of the Russian economy are also provided.
In December 2021, the European Commission proposed a set of stringent amendments to the CBAM draft legislation, expanding the list of goods affected, broadening the emissions scope and accelerating the timeline for implementation of the CBAM. In June 2022 the European Commission agreed to compromise on less-stringent wording which goes outside the scope of this article. The details of proposed amendments assessed in this article thus represent the stricter version of language considered during the review process of the European Commission.
EVALUATION OF THE PROTECTIVE EFFECT OF RAMELTEON IN METHOTREXATE INDUCED NEPHROTOXICITY
Authors: BÜYÜKBAYRAM Halil İbrahim , BAYRAM Dilek , DOĞAN Hatice Kübra 
Published: December 2022

Objective
Methotrexate (MTX), which is used as an
immunosuppressive and anticancer drug, causes
serious toxic side effects in many organs, including
the kidney. Activation of apoptotic pathways through
oxidative stress is involved in the mechanism of MTX
mediated nephrotoxicity. In our study, we investigated
the protective effects of ramelteon (RML), an analogue
of melatonin, whose antioxidant and antiapoptotic
properties are well known, on MTX nephrotoxicity.
Material and Method
32 rats were divided into 4 groups as Control, MTX,
MTX+RML and RML. According to the groups, saline
or RML (10 mg/kg) was administered by oral gavage for
7 days, and on the 2nd day, 20 mg of MTX or the same
volume of saline was administered intraperitoneally
according to the groups. At the end of the experiment,
the rats were sacrificed and kidney tissues were
examined histopathologically with Hematoxylin-Eosin
(HE) staining and immunohistochemically (IHC) with
caspase-3 and TNF-α staining. In addition, serum BUN,
creatinine levels were measured, kidney Total Oxidant
and Antioxidant Status (TAS, TOS) levels were studied
and Oxidative Stress Index (OSI) was calculated.
Results
Creatinine, TOS and OSI levels in the MTX group
were found to be significantly higher than in the control
group. In HE staining, tissue damage was significantly
higher in MTX group compared to the control group,
and cas-3 and TNF-α staining levels were increased in
IHC staining. These findings were found to be reversed
in the MTX+RML group.
Conclusion
We show that RML treatment improves the findings of
MTX-induced nephrotoxicity. RML may be a promising
drug in MTX nephrotoxicity.