bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico investigation of cytochrome bc1 molecular inhibition mechanism against Trypanosoma cruzi
Authors: Muscat Stefano , Grasso Gianvito , Scapozza Leonardo , Danani Andrea 
Published: June 2022

AbstractChagas’ disease is a neglected tropical disease caused by the kinetoplastid protozoan Trypanosoma cruzi. The only therapies are the nitroheterocyclic chemicals nifurtimox and benznidazole that cause various adverse effects. The need to create safe and effective medications to improve medical care remains critical. The lack of verified T. cruzi therapeutic targets hinders medication research for Chagas’ disease. In this respect, cytochrome bc1 has been identified as a promising therapeutic target candidate for antibacterial medicines of medical and agricultural interest. Cytochrome bc1 belongs to the mitochondrial electron transport chain and transfers electrons from ubiquinol to cytochrome c1 by the action of two catalytic sites named Qi and Qo. The two binding sites are highly selective, and specific inhibitors exist for each site. Recent studies identified the Qi site of the cytochrome bc1 as a promising drug target against T. cruzi. However, a lack of knowledge of the drug mechanism of action unfortunately hinders the development of new therapies. In this context, knowing the cause of binding site selectivity and the mechanism of action of inhibitors and substrates is crucial for drug discovery and optimization processes. In this paper, we provide a detailed computational investigation of the Qi site of T. cruzi cytochrome b to shed light on the molecular mechanism of action of known inhibitors and substrates. Our study emphasizes the action of inhibitors at the Qi site on a highly unstructured portion of cytochrome b that could be related to the biological function of the electron transport chain complex.
Foxn1 overexpression promotes thymic epithelial progenitor cell proliferation and mTEC maintenance, but does not prevent thymic involution
Authors: Li Jie , Wachsmuth Lucas P. , Xiao Shiyun , Condie Brian G. , Manley Nancy R. 
Published: June 2022

AbstractThe transcription factor FOXN1 is essential for fetal thymic epithelial cell (TEC) differentiation and proliferation. In the postnatal thymus, Foxn1 levels vary widely between different TEC subsets, from low or undetectable in putative TEC progenitors to highest in the most differentiated TEC subsets. Correct Foxn1 expression is also required to maintain the postnatal microenvironment, as premature down-regulation of Foxn1 causes a rapid involution-like phenotype, while transgenic over-expression can cause thymic hyperplasia and/or delayed involution. In the current study, we investigated a K5.Foxn1 transgene that drives Foxn1 over-expression in TECs, but does not cause hyperplasia, nor does it delay or prevent aging-related involution. Similarly, this transgene cannot rescue thymus size in Foxn1lacZ/lacZ mice that undergo premature involution due to reduced Foxn1 levels. However, K5.Foxn1 transgenics do maintain TEC differentiation and cortico-medullary organization with aging both alone and in hypomorphic Foxn1lacZ/lacZ mice. Analysis of candidate TEC markers showed co-expression of progenitor and differentiation markers as well as increased proliferation in Plet-1+ TECs associated with Foxn1 expression. These results demonstrate that the functions of FOXN1 in promoting TEC proliferation and differentiation are separable and context-dependent, and suggest that modulating Foxn1 levels can regulate the balance of proliferation and differentiation in TEC progenitors.
To explain and to predict: analysis of opportunity recognition on the relationship between personal factors, environmental factors and entrepreneurs' performance
Authors: Alim Md. Abdul , Tan Kim-Lim , Jee Teck Weng , Voon Boo Ho , Hossain Md. Julhaz , Mia Md. Uzzal 
Published: June 2022

PurposeThis paper focuses on the factors that affect entrepreneurs' performance in small and medium enterprises (SMEs) in the context of a developing nation. Despite the advances in this literature, examination of opportunity recognition in the same model with personal factors and environmental factors on entrepreneurs' performance is lacking.Design/methodology/approachA quantitative survey was carried out and the data sample of 198 SMEs entrepreneurs in Bangladesh was collected using quota sampling technique. Partial least squares-based structural equation modeling (PLS-SEM) was employed to test the hypothesized relationships.FindingsThe study found that the direct effect of personal and environmental factors significantly influences entrepreneurs' performance and opportunity recognition, and opportunity recognition significantly influences entrepreneurs' performance. The results further indicated that opportunity recognition mediates the relationships between environmental factors and entrepreneurs' performance, but not on the relationships between personal factors and entrepreneurs' performance.Practical implicationsThe findings from the study guide SMEs entrepreneurs' performance by utilizing the opportunity recognition more efficiently and effectively. The study further enhances practitioners' understanding of the drivers and motivations of entrepreneurs within a developing nation context.Originality/valueAlthough some previous studies already exist that discuss SMEs entrepreneurs' performance, there have been few studies focusing on opportunity recognition and mediation role of opportunity recognition, and far lesser in the context of a developing nation.
Opening up to innovation: emotional intelligence as an intrapersonal resource
Authors: Winton Bradley G. , Sabol Misty A. 
Published: June 2022

PurposeThere is no innovation without ideas. More than ever before, these ideas are increasingly difficult to express in a changing environment ripe with emotions. Today's organizations need to understand why their employees may or may not develop, voice and implement innovative ideas in the face of this emotional tension. Current literature focuses on external factors that empower employees to innovate. This research attempts to shift the focus to the individual by investigating the relationship between emotional intelligence, openness to experience and innovation voicing behavior.Design/methodology/approachThis study employs a quantitative survey among 288 US-based workers to test a mediated model of emotional intelligence, openness to experience and innovation-focused promotive voice. The authors assessed both the measurement and structural models through partial least squares structural equation modeling (PLS-SEM), while controlling for a range of variables with the potential to confound construct measurements.FindingsThe findings validated the positive effect of emotional intelligence on openness to experience, while also finding a significant impact of openness to experience on innovation-focused promotive voice. More importantly, evidence suggests that openness to experience mediates the relationship between emotional intelligence and innovation focused promotive voice.Originality/valueThese findings shed new light on why employees might start the innovation process by developing and, ultimately, voicing innovative ideas. Further, this new insight focuses on the impact of intrapersonal factors as it relates to innovation and attempts to fill a gap in what is known about innovative behavior.
Study of the slipper/swash plate pair loaded with a step motor-spring mechanism in the axial piston pump
Authors: Wang Haiji , Shi Guanglin 
Published: June 2022

Purpose
This paper aims to propose the slipper/swash plate pair loaded with a step motor-spring mechanism to reduce the energy consumption under different rotating rate conditions. The relationship between the operating conditions, oil film thickness and energy consumption is analyzed. The system dynamic model of the slipper/swash plate pair loaded with a step motor-spring mechanism is introduced. Based on the results of the experiment, the PI controller and step motor-spring mechanism are useful for reducing energy consumption.

Design/methodology/approach
This paper introduces the energy consumption of the slipper/swash plate pair. A system dynamic model of the slipper/swash plate pair loaded with a step motor-spring mechanism is introduced too. In the experiment, three step motor and S-type force sensor are used to control the oil film thickness.

Findings
PI controller and the step motor-spring mechanism are useful for controlling the oil film thickness and reducing the energy consumption under different rotating rate conditions. The accuracy of the oil film thickness control is acceptable and the response time is a bit long

Originality/value
PI controller and the step motor-spring mechanism are useful for controlling the oil film thickness and reducing the energy consumption under different rotating rate conditions. The accuracy of the oil film thickness control is acceptable and the response time is a bit long.
Mapping data ethics curricula
Authors: Reeve Jonathan , Zaugg Isabelle , Zheng Tian 
Published: June 2022

Purpose
As data-driven tools increasingly shape our life and tech ethics crises become strikingly frequent, data ethics coursework is urgently needed. The purpose of this study is to map the field of data ethics curricula, tracking relations between courses, instructors, texts and writers, and present a proof-of-concept interactive website for exploring these relations. This method is designed to be used in curricular research and development and provides multiple vantage points on this multidisciplinary field.

Design/methodology/approach
The authors use data science methods to foster insights about the field of data ethics education and literature. The authors present a semantic, linked open data graph in the Resource Description Framework, along with proof-of-concept analyses and an exploratory website. Its framework is open-source and language-agnostic, providing the seed for future contributions of code, syllabi and resources from the global data ethics community.

Findings
This method provides a convenient means of exploring an overview of the field of data ethics’ social and textual relations. For educators designing or refining a course, the authors provide a method for curricular introspection and discovery of transdisciplinary curricula.

Research limitations/implications
The syllabi the authors have collected are self-selected and represent only a subset of the field. Furthermore, this method exclusively represents a course’s assigned literature rather than a holistic view of what courses teach. The authors present a prototype rather than a finished product.

Originality/value
This curricular survey provides a new way of modeling a field of study, using existing ontologies to organize graph data into a comprehensible overview. This framework may be repurposed to map the institutional knowledge structures of other disciplines, as well.
A three-stage grey evaluation method for assessing the performance of interdisciplinary organizations
Authors: Yi Yang , Zhu Jianjun , Tong Huagang 
Published: June 2022

PurposeThis study constructs a three-stage evaluation model for interdisciplinary organizations to solve their ranking problems effectively.Design/methodology/approachA three-stage interdisciplinary organization evaluation model abounds the key problems of “who will evaluate the projects?” and “how to evaluate the projects?”. In the first stage, the authors build a consensus maximization model to identify the selected experts based on the interval grey number because of the uncertainty in assessment. In the second stage, considering the reliability of the experts, the authors calculate the reliability of the experts based on historical data. Meanwhile, considering the gradual changes of the experts, the dynamic weighting method is obtained based on the clustering method. In the third stage, considering decision-makers regret psychological behavior, the authors construct a cross-organizational performance evaluation model based on consensus expectations.FindingsFirst, for selecting the experts responsible for assessing interdisciplinary organizations, the consensus-reaching method can effectively avoid cognitive bias. Second, during the assessment, the authors obtained more reasonable results by considering the psychological changes of experts based on regret theory. Third, based on the results, the cross-organization of colleges focused on the achievements of talent training, cross effects, and system construction.Practical implicationsOur study could help organizations establish a suitable assessment mechanism and promote interdisciplinary development.Originality/valueFirst, considering the importance of selecting the experts, the authors use the consensus-reaching process for expert selection. This method could guarantee most experts' preferences. Then, the authors propose a two-stage dynamic weighting method, including a pre-determined and adjusted process. The dynamic method can better perform the preferences of experts. Third, the authors studied the assessment in interdiscipline. In addition, based on the framework and considering the features of the interdiscipline, the authors use the grey number to perform the uncertain preferences of the experts using regret theory.
Does visual attention help? Towards better understanding and predicting users’ good abandonment behavior in mobile search
Authors: Wu Dan , Zhang Shutian 
Published: June 2022

PurposeGood abandonment behavior refers to users obtaining direct answers via search engine results pages (SERPs) without clicking any search result, which occurs commonly in mobile search. This study aims to better understand users' good abandonment behavior and perception, and then construct a good abandonment prediction model for mobile search with improved performance.Design/methodology/approachIn this study, an in situ user mobile search experiment (N = 43) and a crowdsourcing survey (N = 1,379) were conducted. Good abandonment behavior was analyzed from a quantitative perspective, exploring users' search behavior characteristics from four aspects: session and query, SERPs, gestures and eye-tracking data.FindingsUsers show less engagement with SERPs in good abandonment, spending less time and using fewer gestures, and they pay more visual attention to answer-like results. It was also found that good abandonment behavior is often related to users' perceived difficulty of the searching tasks and trustworthiness in the search engine. A good abandonment prediction model in mobile search was constructed with a high accuracy (97.14%).Originality/valueThis study is the first to explore eye-tracking characteristics of users' good abandonment behavior in mobile search, and to explore users' perception of their good abandonment behavior. Visual attention features are introduced into good abandonment prediction in mobile search for the first time and proved to be important predictors in the proposed model.
Biological Flora of Britain and Ireland:Knautia arvensis
Authors: Varga Sandra , Soulsbury Carl D. , John Elizabeth A. 
Published: June 2022

AbstractThis account presents information on all aspects of the biology ofKnautia arvensis(L.) Coult. (Field Scabious) that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard framework of theBiological Flora of Britain and Ireland: distribution, habitat, communities, responses to biotic factors, responses to environment, structure and physiology, phenology, floral and seed characters, herbivores and disease, history and conservation.Knautia arvensisis a perennial hemicryptophyte, with a tap root system, and bluish‐lilac inflorescences. It is native in Britain. It occurs predominantly on well‐drained to moderately dry soils such as dry grassy fields, pastures, roadsides and dry hedge banks. It has a vast Eurasian native distribution.Reproduction occurs through the production of seeds and rhizomes, thoughK. arvensispossesses very limited clonal growth. It has a gynodioecious breeding system. Flowers are nectariferous and insect pollinated, showing sexual dimorphism in several traits. The hermaphroditic flowers are protandrous and self‐compatible. Flowers are mainly pollinated by butterflies (Lepidoptera), Hymenoptera, Coleoptera and Diptera.Knautiais a genus noteworthy for its high occurrence of hybridisation and polyploidy.Knautia arvensishas the widest distribution within the genus, and hybridisation both within members of the same group and with taxa of other groups is frequently reported.Although declining in natural habitats within England,K. arvensisis increasingly being sown within wildflower seed mixtures used in restoration schemes across the country, as it is a late flowering species that provides a good source of nectar for pollinators.
Thomas Sinclair and the Political Representation of Presbyteria 1892–1912
Authors: Holmes Richard 
Published: June 2022

AbstractThomas Sinclair was a Belfast merchant who exercised a crucial influence on the formation of Ulster Unionism in the period 1886–1912. He had been a leading Presbyterian Liberal; but on Gladstone's conversion to Irish home rule became president of the Liberal Unionists, and worked over the next decades to secure the alliance of Presbyterian Liberals and Conservatives to resist home rule. This article will consider the extent to which a Presbyterian Liberal element remained within this unionist alliance by examining a series of elections, in which former Liberals challenged the policy of Thomas Sinclair and the unionist candidates he backed. It will focus on two pressure groups, the Presbyterian Unionist Voters Association (PUVA) and the Russellites, on the links between them, and on the role of one‐time Liberal Unionist MP, T.W. Russell.
Impacts and Opportunities at the Climate–Land Use–Energy–Water Interface: An Urgent Call for Dialogue
Authors: Jacobs Kathy , Holway Jim , Hanak Ellen , Quay Ray , Sternlieb Faith , Udall Brad 
Published: June 2022

AbstractHistorically, managers of land, energy, and water systems have not recognized the importance of the collective interconnections of these systems. It is simpler to think about these intersections as two‐dimensional rather than multi‐dimensional puzzles. However, in the context of climate change, the multiple intersections between systems need to be examined. Failure to consider those connections can result in under‐appreciated risks, missed opportunities, and costly mistakes. Additionally, issues have different implications over time and spatial scales, and when considered in local contexts, are more nuanced and complex. Recent events also emphasize the critical need to consider social and environmental justice and to engage a range of interests in decision‐making processes. As policy makers, resource managers, and researchers, we must ask ourselves the tough questions that will lead to innovation and creative solutions. Questions about the potential unintended consequences and the political, social, economic, natural and/or ecological, hydrological, and technical feasibility of actually implementing solutions have largely gone unanswered. We call on our colleagues to work together on these challenges; to develop and use integrated tools like scenario planning and anticipatory decision frameworks; and collaborate on creating a “virtuous intersection.” Join us in analyzing and implementing policy at the climate–land–energy–water interface.
A single‐center COVID‐19 vaccine experience with CoronaVac and BNT162b2 in familial Mediterranean fever patients
Authors: Güven Serdar Can , Karakaş Özlem , Atalar Ebru , Konak Hatice Ecem , Akyüz Dağlı Pınar , Kayacan Erdoğan Esra , Armağan Berkan , Gök Kevser , Doğan İsmail , Maraş Yüksel , Erden Abdulsamet , Erten Şükran , Küçükşahin Orhan , Omma Ahmet 
Published: June 2022

AbstractAimTo determine frequency of adverse events and attacks related to vaccination in recipients of CoronaVac and BNT162b2 in familial Mediterranean fever (FMF) patients, and to search whether history of prior COVID‐19 or a booster dose increases occurrence of adverse events/attacks.MethodsFMF patients were surveyed for administration of any COVID‐19 vaccine and vaccine‐related adverse events or FMF attacks. Demographic, clinical, vaccine‐related data, history of COVID‐19 infection before or after vaccination, adherence to FMF treatment during vaccination were collected.ResultsA total of 161 vaccinated FMF patients were included. Ninety‐three patients out of 161 had reported suffering from an adverse event/attack after a vaccine dose. There were 54.7% of BNT162b2 recipients who reported any adverse event after any vaccine dose in comparison to 29.9% of CoronaVac recipients (P < .001). There were 22.2% of BNT162b2 recipients who reported suffering from a FMF attack within 1 month after vaccination in comparison to 19.4% of CoronaVac recipients (P = .653). When patients with or without adverse event/attack were compared, no significant differences were observed in means of demographics, comorbid diseases, disease duration, total vaccine doses, or treatments adhered to for FMF. Rates of adverse events/attacks were similar between patients with and without prior COVID‐19. In booster recipients, adverse events/attacks were most frequent after the booster dose.ConclusionsA considerable number of FMF patients suffered from vaccine‐related adverse events/attacks, particularly with BNT162b2. No serious events or mortalities due to vaccination were detected. Demographics, clinical characteristics and prior history of vaccination did not significantly affect these results. We observed an increased rate of adverse events/attacks with booster dose administration.
Coupling methanogenesis with iron reduction by acetotrophic Methanosarcina mazei zm‐15
Authors: Yang Zhen , Lu Yahai 
Published: June 2022

AbstractApplication of ferric iron is conventionally considered to inhibit methanogenesis in anoxic environments. Here we show that Methanosarcina mazei zm‐15, a strain isolated from the natural wetland of Tibetan plateau, is capable of Fe(III) reduction, which significantly promotes its growth and methanogenesis. We grew Ms. mazei zm‐15 in a medium containing acetate supplemented with Fe(III) in ferric citrate or ferrihydrite and to some cultures anthraquinone‐2,6‐disulfonate (AQDS) was applied as an electron shuttle. The reduction of Fe(III) species occurred immediately. Ferric citrate was more readily reduced than ferrihydrite. The X‐ray diffraction spectra analysis showed the formation of magnetite from ferrihydrite and amorphous reduced products from ferrihydrite plus AQDS. The analysis of protein contents revealed that Fe(III) reduction contributed 36%–46% of the cell growth. The growth yield, estimated as protein increment per acetate consumed for Fe(III) reduction, increased by 20‐ to 30‐fold compared with methanogenesis, which is in consistence with the difference in free energy available by Fe(III) reduction relative to methanogenesis. We propose that the outer‐surface multiheme c‐type cytochrome predicted from Ms. mazei zm‐15 genome serves as the terminal reductase with the energy‐converting hydrogenase and F420H2 dehydrogenase involved in electron transport chain for Fe(III) reduction. The findings shed a light to better understand the ecophysiology of Methanosarcina in anaerobic environments.