bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent advances on structural, thermal, vibrational, optical, phase transitions, and catalysis properties of alkylenediammonium halogenometallate materials (Metal: Bi, Sb, Halogen: Cl, Br, I)
Authors: Ouasri Ali 
Published: July 2022

Abstract
This paper aims to review recent advances on synthesis, crystal structures, thermal, spectroscopic, phase transitions, optical, dielectric, and catalysis properties of hydrate and anhydrous alkylenediammonium halogenometallates materials (Metal: Bi, Sb, Halogen: Cl, Br, I). These hybrid materials present rich structural diversities based on octahedra forming infinite zero dimensional, 1-dimensional chains, 2-dimensional layers, discrete bioctahedra, and discrete tetramer units. The effect, contribution and importance of hydrogen bonding N–H … X (X: Cl, Br, I) are reviewed in terms of solid state relationship. Particularly, a comparative study is made on hydrate and anyhdrous aliphatic chlorobismuthates with alkylenediammonium +NH3(CH2)
n
NH3
+ based on structural data and V/Z variation with (CH2)
n
chains (n = 2–8, 12), and variation of BiCl6
3− Raman frequencies modes versus (CH2)
n
chains (n = 3–8). Hydrate salts with (n = 3, 12) consist of isolated BiCl6
3− anions and two water molecules, against others ones with isolated anionic chains [BiCl5
2−]
n
or Bi2Cl10
4− dimers, formed by distorted octahedra BiCl6
3− sharing corners, vices or edges. The reviewed optical and electronic band gaps suggested interesting compounds with band gaps (1.85–2.4 eV), as suitable materials in optoelectronic properties, photoactive layer in solution-processed photovoltaics, and bio-imaging or photovoltaic applications. It was concluded that iodobismuthate salts have generally the lowest bands gap, compared to that of bromo and chlorobismuthate slats. Catalysis proprieties are reviewed n fast (RhB) degradation under dark conditions for (C4N2H7)4Bi2Cl10, (C5H9N2)BiI4, and {(H-BPA)4·[(BiI6)I13]·2I3}
n
, and in organic salts synthesis under solvent-free conditions. Herein NH3(CH2)
n
NH3BiCl5 (n = 5–7) salts were used as highly efficient catalysts, which is a novel tendency in chlorobismuthate researchs in the green chemistry field.
Isometric Resistance Training Is Recommended as a Safe and Effective Adjunct Therapy to Reduce Blood Pressure
Authors: Koziris Lymperis (Perry) 
Published: July 2022

ABSTRACT
Most scientific organizations recommend isometric resistance training (IRT) to manage blood pressure (BP), whereas some still do not. A typical grip IRT program of 4 × 2-minute 30%-intensity efforts with 1–3-minute rest periods, performed ≥3×/week for ≥8 weeks, can be efficient, safe, and relatively inexpensive. It can help decrease resting BP at least as much as aerobic or dynamic resistance training. IRT can be as effective as one antihypertensive medication and likely lessens strokes and myocardial infarctions. It can be as safe as other exercise modes regarding acute BP rise and safer than aerobic exercise regarding cardiac demand. Grip IRT is currently more conducive than leg IRT to program delivery. These highlights come from an expert-panel consensus reached through a largely anonymous multistep process, agreeing with the organizations that support IRT. To follow the science on IRT and BP, exercise and health care practitioners should seek corroboration from the guidelines of multiple organizations.
Scalp-and-Replacement of Oversize Particles: Laboratory Permeameter Testing
Authors: Vinoth Ganapathiraman , Fannin R. Jonathan 
Published: July 2022

Abstract
A reanalysis is made of 24 rigid-wall permeameter tests on eight widely-graded sand-gravel mixtures, using empirical methods that post-date the original study by Jones in 1955. The reanalysis is conducted to better understand the consequences of the scalp-and-replacement method of removing oversize particles in laboratory permeameter testing. A necessary requirement of the scalp-and-replacement method is that the porosity, hydraulic conductivity, and susceptibility of the test gradation to internal instability be largely unchanged. The reanalysis provides a framework for such considerations and serves to identify the consequences of excessive scalping such as increased porosity and hydraulic conductivity. The results show that scalp-and-replacement to 35 % of the gradation curve imparts no significant change to the porosity and hydraulic conductivity of an internally stable gradation.
A Phase I, Randomized, Single-Ascending-Dose, Multiple-Dose, and Food-Effect Trial of the Safety, Efficacy, and Pharmacokinetics of Topiroxostat in Healthy Chinese Participants
Authors: Ye Suiwen , Zhuang Wei , Lin Yunni , Lai Xiuping , Chen Junyi , Wang Jing , Zhong Guoping , Yao Herui , Wu Junyan 
Published: July 2022

Abstract

Background: As the structure of the human diet changes, the prevalence of hyperuricemia is increasing each year. Hyperuricemia and its comorbidities, such as gout, severely affect quality of life. Moreover, hyperuricemia causes renal impairment and is associated with chronic kidney disease. Topiroxostat, a selective xanthine oxidoreductase inhibitor, has been approved to treat hyperuricemia or gout in Japan. Topiroxostat has shown good tolerance and efficacy in the Japanese population. However, its pharmacokinetic (PK) characteristics, efficacy, and safety in the Chinese population remains unknown.

Objective: This trial evaluated the PK profile, safety, efficacy, and food effects of Topiroxostat in healthy Chinese participants.

Methods: The major endpoint was determination of the PK profile of Topiroxostat. Topiroxostat concentrations were detected with LC-MS/MS. PK parameters were calculated in Phoenix WinNonlin 8.1. Minor endpoints were safety and efficacy assessments. Assessment of adverse events and safety was performed by clinicians. Plasma uric acid concentration (ΔECmax and ΔAUEC) was determined as the pharmacodynamic index. This study consisted of three arms: single ascending dose (20, 40, and 80 mg, N = 10), multiple dose (80 mg BID, 7 days, N = 10), and food effects (40 mg single dose, fasting-fed cross-over design, N = 10).

Results: In the single-ascending-dose arm, Topiroxostat showed rapid absorption and excretion, with Tmax <1.6 h and T1/2 2.49–3.72 h. Additionally, Topiroxostat showed a wide distribution, on the basis of moderate Vz/F (242.8–336.36 L). The main PK parameters Cmax, AUC0-t, and AUC0-C showed a linear relationship with dose (R2 = 0.5146, 0.8416, 0.8386, respectively). In the multiple-dose arm, no significant differences were observed in Cmin on days 3–6 (P = 0.265). No serious adverse events were observed. Regarding efficacy, plasma uric acid levels were controlled to low levels during multiple-dose administration. In the food-effects arm, the fed group showed a lower Cmax than the fasting group (316.00 ± 135.81 vs. 478.40 ± 175.42 ng/mL, P = 0.033) but demonstrated better efficacy (ΔECmax, P < 0.001; ΔAUEC, P < 0.001).

Conclusions: Topiroxostat showed rapid absorption and a broad distribution in healthy Chinese adults. Additionally, it showed good safety and tolerance in the Chinese population. Moreover, the pharmacodynamic profile indicated that post cibum administration increased the efficacy of Topiroxostat.
Non-surgical orbital decompression using diuresis in dysthyroid optic neuropathy: a case report
Authors: Erdei Annamaria , Gazdag Annamaria , Ujhelyi Bernadett , Nagy Edit B , Berenyi Ervin , Berta Eszter , Steiber Zita , Barna Sandor , Mezosi Emese , Bodor Miklos , Nagy Endre V 
Published: July 2022

Introduction
Dysthyroid optic neuropathy (DON) is a rare, severe form of thyroid eye disease, in which decreased visual acuity is accompanied by characteristic MRI findings. The treatment of DON has always been a challenge.

Case presentation
In a patient in whom visual acuity deteriorated on the left eye, mannitol 20% 200 mL followed by furosemide 40 mg 6 h later, administered daily, were initiated on the day of admission. Visual function by ophthalmology methods, and orbital compartment volumes and water content by MRI were followed. Intravenous diuretics resulted in an immediate therapeutic response. Visual acuity improved from 20/50 to 20/25 after 2 days of treatment. MRI revealed decreasing water content of both the muscle and connective tissue compartments without any volume changes. Subsequently, corticosteroids and orbital irradiation were started. Orbital decompression surgery was not required.

Discussion/conclusion
Edematous swelling of orbital tissues is an established contributor of local pressure increase in thyroid eye disease. Diuretics reduce orbital pressure and, if confirmed by others, may be useful additions to the standard of care in sight-threatening DON.
Criptomonedas y su efecto en la estabilidad del sistema financiero internacional: Apuntes para Centroamérica
Authors: Salas-Ocampo Luis Diego , Alfaro-Salas Marly 
Published: July 2022

This research seeks to establish some of the implications for the stability of the international financial system of capital movements that occur in the context of the use of cryptocurrencies as legal tender and as an investment asset, trying to observe some specific lines for the Central American case. It addresses global entities of the international financial system, central banks of several continents and Central America. I makes evident the discourse and practices from a qualitative perspective using the discourse analysis technique which is combined with descriptive statistical analysis on the number of cryptocurrency owners in countries. It concludes that there is a relationship between the 2008 financial crisis and a very strong movement of the technical and computer sectors in the line of generating a whole process of reconceptualization and repositioning as financial consumers in the international and national financial system. In addition, it visualizes three possible scenarios for resolving the tension between the private cryptocurrency instrumental sectors and international banking. On the other hand, it determines that in Central America there are no operational and technical conditions for the generation of Central Bank policies in relation to the incorporation of these in digital currencies.
Medication‐resistant acute focal motor seizures in a child with COVID‐19 affecting the CNS
Authors: Sadeghian Saeid , Momen Aliakbar , Jelodar Gholamreza , Nasiri Shahram , Azizimalamiri Reza 
Published: July 2022

AbstractA perfectly healthy preschool girl presented with acute repetitive focal aware motor seizures, while her brain MRI showed a lesion in the left posterior cortex. After a number of investigations, her cerebrospinal fluid PCR was positive for SARS‐CoV‐2. Despite receiving at least four anti‐seizure medications at appropriate dosages, the seizures continued, and just after administering intravenous immunoglobulin, her seizures stopped. This dramatic response to intravenous immunoglobulin may indicate a hypothetical inflammatory process in the patient’s cortex caused by COVID‐19.
AUDIOVISUAL SPEECH PERCEPTION IN DIOTIC AND DICHOTIC LISTENING CONDITIONS
Authors: Vinay Sandhya , Swarnalatha Nagaraj Vinay 
Published: July 2022

BackgroundSpeech perception is multisensory, relying on auditory as well as visual information from the articulators. Watching articulatory gestures which are either congruent or incongruent with the speech audio can change the auditory percept, indicating that there is a complex
integration of auditory and visual stimuli. A speech segment is comprised of distinctive features, notably voice onset time (VOT) and place of articulation (POA). Understanding the importance of each of these features for audiovisual (AV) speech perception is critical. The present study investigated the perception of AV consonant-vowel (CV) syllables with various VOTs and POAs under two conditions: diotic incongruent and dichotic congruent.Material and methodsAV stimuli comprised diotic and dichotic CV syllables with stop consonants (bilabial /pa/ and /ba/; alveolar /ta/ and /da/; and velar /ka/ and /ɡa/) presented with congruent and incongruent video CV syllables with stop consonants. There were 40 righthanded
normal hearing young adults (20 females, mean age 23 years, <i>SD</i> = 2.4 years) and 20 males (mean age 24 years, <i>SD</i> = 2.1 years) who participated in the experiment.ResultsIn the diotic incongruent AV condition, short VOT (voiced CV syllables) of the visual segments were identified when auditory segments had a CV syllable with long VOT (unvoiced CV syllables). In the dichotic congruent AV condition, there was an increase in identification of the audio segment when the subject was presented with a video segment congruent to either ear, in this way overriding the otherwise presented ear advantage in dichotic listening. Distinct visual salience of bilabial stop syllables had greater visual influence (observed as greater identification scores) than velar stop syllables and thus overrode the acoustic dominance of velar syllables.ConclusionsThe findings of the present study have important implications for understanding the perception of diotic incongruent and dichotic congruent audiovisual CV syllables in which the stop consonants have different VOT and POA combinations. Earlier findings on the
effect of VOT on dichotic listening can be extended to AV speech having dichotic auditory segments.
Tres reductos del cuento La fiera exige alimento
Authors: Abenójar Óscar 
Published: July 2022

Este trabajo analiza tres versiones de una fábula que no tiene asignada una entrada específica en los índices internacionales de cuentos. Según los tres paralelos conocidos del relato, un león amenaza a un labrador con devorarlo, a menos que este le entregue alimento periódicamente. Cuando al protagonista se le agotan víveres, un zorro se ofrece a a deshacerse del felino a cambio de unas gallinas. Gracias a la ayuda de la raposa, el hombre logra matar al león, pero, en lugar de retribuir al zorro con la recompensa, lo que hace el hombre es entregarle un saco lleno de perros. Dos versiones de este cuento fueron documentadas en del norte de África; y la tercera fue registrada, en lengua maya, en el Yucatán mexicano. En este estudio se cotejan esos tres paralelos del relato y se analizan sus vínculos con otros cuentos tradicionales. Los resultados demuestran que, en muchas ocasiones, las claves para entender de manera cabal las narraciones orales se encuentran en culturas muy distantes y en regiones muy remotas.
The Digital Life of Modern Corporations: Corporate Management Mechanisms and What the Future Holds
Authors: Laptev V. A. 
Published: July 2022

Digital transformation of the economy has redefined approaches to the issues of legal capacity, corporate governance and management of business processes. Traditional management mechanisms are no longer competitive unless used in conjunction with dynamically developing digital technologies. This article reviews the lifecycle of a “digital corporation” from the moment of its establishment (i.e., from the moment it acquires legal capacity), the processes related to its governance and management (intra-corporate and intra-productive relations), as well as the documentation of the outcome of its business and production activities. We discuss the “digital footprint” left by corporations in public registers, a unified space of trust implemented as a digital interactive environment, “digital afterlife,” and the adjustment of the legal capacity of corporations in view of the automation of their business processes. Furthermore, we provide several examples of digital management tools that are replacing traditional forms of management that rely solely on human cognition. We introduce three types of digital management: remote management (exercised by humans); smart management (based on algorithms designed by human engineers); and artificial intelligence (AI) management (that does not require human involvement). The article discusses the distinctive characteristics of each of these types of management and their potential joint application. Legal risks associated with the use of digital technologies for the assessment and documentation of production and economic activities (e-accounting, cloud data, open-access information, public registers) are identified. The study relies on empirical economic, legal and technological data pertaining to the legal status of a modern mixed-capital business corporation. We present an overview of currently available IT solutions for digital corporation (e-corporation) management and modification of traditional management tools, and provide an assessment of the prospects for the future development of these technologies. We emphasize the role of law in the digitalization of the economy and offer approaches to legislative work aimed at the legal regulation of modern corporate management.
Predictive Policing: High-tech Modeling as a Method to Identify Serial Killers
Authors: Bertovskiy L. V. , Novogonskaya M. S. , Fedorov A. R. 
Published: July 2022

The article considers the development of predictive policing in Russia through the creation of software, based on the use of artificial intelligence (AI) to identify serial killers. Forensic modelling in crime investigation, in particular modern digital twin technology is analyzed. The system of the digital twin is trained on the basis of a set of mathematical models of various level of complexity and specified by results of full-scale experiments. Existing approaches to solving the serial killer portrait problem are investigated. Digital twins in conjunction with machine learning can predict the behavior of the object under study in the future, based on statistical data and accelerate the work of the investigator in the investigation of serial crimes.
EMOTICEME “SURPRISE” IN THE ASPECT OF PROJECTIVELY AND PRA GMATICALLY CONSTRUCTED INFORMATION
Authors: Анумян К.С. , Карабулатова И.С. 
Published: July 2022

Представлен анализ способов выражения эмотикемы «удивление» прямым и косвенным речевым актом в языке. Работа проводится в рамках антропоцентрической научной парадигмы и стоит на стыке таких важнейших для современной лингвистики дисциплинарных областей, как эмотиология, лингвокультурология, психолингвистика, этнолингвистика. Также рассмотрены основные идеи и понятия, необходимые для проведения анализа, и проблемы, связанные со способами представленности эмотикемы «удивление» в русском языке. По результатам анализа практического материала выявлено, что эмотикема «удивление» чаще всего представлена проективно построенным текстом – прагматически она реализуется редко, в основном это описательно представленная информация.
Th e article is devoted to the analysis of the ways of expressing the emoticeme of surprise by direct and indirect speech act in the Russian language. Th e work is carried out within the framework of the anthropocentric scientifi c paradigm and stands at the crossroads of such important disciplinary areas for modern linguistics as emotiology, linguoculturology, psycholinguistics, ethnolinguistics. We also consider the main ideas and concepts that are necessary for the analysis, as well as problems related to the ways of representing the emoticeme of surprise in the Russian language. as the analysis of practical material shows, the emoticeme of surprise is most oft en represented by a projectively constructed text: pragmatically it is rarely realized, mostly it is descriptive information presented.
CENSORSHIP IN THE COVERA GE OF TOPICS OF INFORMATION TENSION AND CONFLICT IN THE GERMAN INTERNET SPACE
Authors: Кириллов А.В. , Карабулатова И.С. 
Published: July 2022

Рассмотрены ситуации с цензурой в Интернете в Германии. Предпринята попытка проследить и выявить причины развития контроля публикаций в социальных сетях. Даны характеристики медиапространства в Германии в целом и освещены попытки выхода на него новых участников. Изучены эффективность используемых методов контроля и общие тенденции развития медиапространства.
Th is article is devoted to the study of the situation with Internet censorship in Germany. an att empt has been made to trace and identify the reasons for the development of the control of publications in social networks. Th e article describes the characteristics of the media space in Germany as a whole and highlights the att empts of new participants to enter it. Th e eff ectiveness of the control methods used and the general trends in the development of the media space are studied.
Monogenic Disorder Associated with Autoimmune Lymphoproliferative Syndrome -Like Phenotype: A Systematic Review
Authors: Nirouei Matineh , Hafezi Nasim , Rasouli Seyed Erfan 
Published: July 2022

Background: Autoimmune lymphoproliferative syndrome (ALPS) is a congenital disorder that results in an apoptosis impairment of lymphocytes, leading to chronic lymphoproliferation and autoimmunity, mainly autoimmune cytopenia. Some of autoreactive T cells cannot become apoptosis in activation-induced cell death (AICD) pathway; therefore, they have accumulation of autoreactive TCRαβ+CD4−CD8− doublenegative T (αβ- DNT) cells, leading to cytopenia, splenomegaly, lymphadenopathy, autoimmune disorders and a greatly increased lifetime risk of lymphoma. FAS, FASL, CASP8 and CASP10 gene defects are often responsible for the disease, the phenotype of which can vary from asymptomatic/mild forms to severe disease. More rarely, defects are associated to other genes involved in ALPS-like phenotype.
Methods: A systematic literature search was performed in Web of Science, PubMed and Scopus from the earliest available date to march 2021 with standard keywords to find patients with ALPS-like phenotypes. Demographic, clinical, immunological and molecular data were extracted.
Results: In this systematic review we reported 61 patients with genetically determined ALPS-like. Most of ALPS-like cases carry mutations in the STAT3 (n=15), LRBA (n=11) and CARD11 (n=8) genes. The most common presentation was splenomegaly and lymphadenopathy followed by hepatomegaly. The most common autoimmunity was autoimmune hemolytic anemia and immune thrombocytopenic purpura followed by auto immune neutropenia. Elevated serum immunoglobulin was reported especially in IgG, IgM and IgA.
Conclusion: In the present study, 61 patients with genetically determined ALPS-like were examined. Our results showed that most of ALPS-like cases carry mutations in the STAT3. We reported that the most common presentations were splenomegaly and lymphadenopathy. Elevated serum immunoglobulin, IL-10, vitamin B12 and increased proportion of DNT cells were reported.