bluuebunny/crossref_metadata_2025_split huggingface dataset:
La dynamique démocratique de l’économie sociale
Authors: Celle Sylvain 
Published: January 2022

Cette thèse porte sur la dynamique historique de l’économie sociale dans le capitalisme français du xixe siècle à nos jours. Les organisations de l’économie sociale (coopératives, mutuelles, associations, etc.) développent des systèmes de règles originaux au sein des économies capitalistes. L’une de nos hypothèses est que les règles démocratiques au sein de ces organisations jouent un rôle déterminant dans l’autonomisation et la différenciation de l’économie sociale par rapport aux régulations du capitalisme. Pour éprouver cette hypothèse, nous appuyons notre recherche sur une approche institutionnaliste de l’économie sociale, notamment à travers une vaste enquête historique, utilisant principalement des méthodes qualitatives comme les études de cas approfondies. Cette thèse contribue ainsi à l’approfondissement de nos connaissances historiques et analytiques de l’économie sociale. Elle permet également de démontrer le rôle de la démocratie dans la différenciation de certains systèmes de règles au sein des économies capitalistes.
Abordaje mini-invasivo en un tiempo de cáncer de colon metastásico.
Authors: Avellaneda Nicolás , Veracierto Federico , Carrie Augusto , Lancelotti Tomas , Salgado (h) Roberto , Oddi Ricardo 
Published: January 2022

Una paciente femenino de 49 años de edad que consulta por un año de evolución de dolor abdominal, pérdida de peso y alteración del ritmo evacuatorio asociada a proctorragia. Al examen físico presenta tumor palpable en hemiabdomen izquierdo.
La colonoscopía evidencia un tumor a nivel del sigma infranqueable con el endoscopio (adenocarcinoma). Para estadificar dicho tumor, se realiza tomografía computada que evidencia una lesión periférica única en segmento VI hepático. Dicha tomografía se complementa con una resonancia magnética que no evidencia otras lesiones a nivel hepático. Los marcadores tumorales en sangre se encontraban ligeramente aumentados.
Se discute el caso en comité multidisciplinario, tomando la decisión de realizar un abordaje simultáneo de las lesiones en colon e hígado, y posteriormente realizar tratamiento adyuvante.
Durante el procedimiento se realiza una laparoscopía exploradora que no evidencia secundarismo a nivel peritoneal, y a nivel de colon sigmoides se observa un tumor de gran tamaño que por contiguidad invade el ovario y la trompa izquierdos. Por último, a nivel hepático puede verse la metástasis única a nivel de segmento VI, ya conocida. Se decide realizar una colectomía izquierda laparoscópica asociada a resección de trompa y ovario izquierdos, procedimiento llevado a cabo por el equipo de cirugía colorrectal. Posteriormente, el equipo de cirugía hepática realiza una metastasectomía laparoscópica.
La paciente recibe el alta sanatorial al cuarto día postoperatorio sin intercurrencias, y posteriormente comienza con tratamiento adyuvante con quimioterapia sistémica.
PENGARUH DIRECT LABOR COST DAN BIAYA MAINTANANCE MESIN PRODUKSI INJECTION TERHADAP VOLUME PRODUKSI KURSI PLASTIK NAPPOLY (BIG 909) STUDI KASUS DI PT. CAHAYA BUANA INTITAMA BOGOR
Authors: SATRIA MUHAMMAD , Syaiful Anwar Kemal 
Published: January 2022

Penelitian ini mempunyai tujuan untuk mengetahui dan menganalisis pengaruh Direct Labor Cost Dan Biaya Maintanance Mesin Produksi Injection Terhadap Volume Produksi Kursi Plastik Nappoly (Big 909) Study Kasus Di PT. Cahaya Buana Intitama Bogor. yang man jenis penelitian yang digunakan menggunakan kuantitatif metode dengan populasi yaitu seluruh data laporan keuangan yang terdapat pada perusahaan PT. Cahaya Buana Intitama. Adapun alat analisis yang digunakan yaitu uji normalitas, uji analisis korelasi person product momen, analisis korelasi berganda, regresi linier berganda, koefisien determinasi, uji t (parsial), dan uji f (stimultan). Didalam analisis menggunakan IBM Statistics Versi 25.0 dapat disimpulkan hipotesis pertama terdapat pengaruh secara negatif direct labor cost terhadap volume produksi, hipotesis kedua terdapat pengaruh positif biaya maintanance mesin produksi injection terhadap volume produksi kemudian hipotesis ketiga berpengaruh secara simultan antara direct labor cost dan biaya maintanance mesin produksi injection terhadap volume produksi.
Production of Hyaluronic Acid from Molasses by Streptococcus thermophilus TISTR 458
Authors: Saraphanchotiwitthaya Aurasorn , Sripalakit Pattana 
Published: January 2022

The purpose of this study was to investigate the capability of Streptococcus thermophilus TISTR 458 on hyaluronic acid (HA) production by using various carbon sources including glucose, sucrose and sugarcane molasses. HA production was determined using a turbidity assay by precipitation with cetyltrimethylammonium bromide (CTAB) and the sugar content was analysed by a sulphuric acid-UV spectrophotometry method. The results showed that S. thermophilus TISTR 458 produced the maximal yield of HA from glucose, sucrose and molasses at approximately 32.80 ± 4.27 (24 h), 79.03 ± 8.36 (24 h) and 213.44 ± 76.79 (12 h) mg/L, respectively, then decreased gradually. Moreover, an elevated level of HA was related to a reduction in the sugar content. It was concluded that S. thermophilus TISTR 458 can produce HA by using glucose, sucrose and molasses. Interestingly, molasses as a cheap agricultural by-product is a promising prospect carbon source for HA production by S. thermophilus TISTR 458.
HIGHLIGHTS

Searching for alternatives sources such as agro-industrial by-products to produce biomolecules has been an increasing trend nowadays
Various carbon sources have been used for hyaluronic acid (HA) production by Streptococcus thermophilus TISTR 458, the culture collection in Thailand
Sugarcane molasses, a cheap agricultural by-product was a promising prospect carbon source for HA production by thermophilus TISTR 458

GRAPHICAL ABSTRACT
ČOVJEKOV UTICAJ NA OKOLIŠ S AKCENTOM NA OTPAD
Authors: Muhamedagić Fatima , Ramulić-Mujkić Anita 
Published: January 2022

Čovjek sa stanovišta ekologije predstavlja jedan od nezaobilaznih ključnih ekoloških faktora okoliša koji se, pored ostalog, izrazito pojavljuje u segmentu nastanka otpada i u segmentu upravljanja otpadom. Sa stanovišta islama on je namjesnik koji remeti stanje i čini nered u okolišu. Čovjekov uticaj u segmentu nastanka otpada često se pored okolišnog i pravnog aspekta sagledava i s religijskog aspekta.
Otpad prema nacionalnoj definiciji u Bosni i Hercegovini podrazumijeva sve tvari ili predmete koje vlasnik odlaže, namjerava odložiti ili se traži da budu odložene u skladu s jednom od kategorija otpada navedenoj u listi otpada.
U današnjem vremenu problematika otpada predstavlja dio globalnih ekoloških problema savremenog svijeta u kojem je čovjek, sa svojim aktivnostima, odlučujući faktor u mijenjanju okoliša. Sve aktivnosti povezane su uglavnom s njegovim zadovoljavanjem potreba. U vezi s tim postoje i mehanizmi regulacije koji se najčešće u našoj zemlji oslanjaju na pravnu regulativu. Pored pravnih mehanizama postoje i religijski (islam) i ekološki mehanizmi.
Refractive Errors and Concomitant Strabismus in Children and Adolescents: A Hospital Based Observational Study
Authors: Singh Anupam , Chawla Omna , Verma Rupal , Saxena Vartika , Kumari Ranjeeta , Patnaik Nisheeta , Kumar Barun , Kumawat Devesh 
Published: January 2022

Purpose:
To study the different types of concomitant strabismus and associated refractive errors in children and adolescents.

Material & Methods:
In this observational study, 178 patients aged between 4-19 yrs with concomitant strabismus of ≥ 15 Prism Dioptre (PD) on prism bar cover test were included and examined by a strabismus expert for type and amount of deviation between July 2017 to June 2020 at a tertiary health care hospital in north India. Non-cycloplegic and cycloplegic refraction was performed by a trained optometrist. Glasses were prescribed to achieve the best corrected visual acuity (BCVA). Data collection was done using a predesigned and pretested questionnaire.

Results:
The mean age of the study population was 11.20 ± 5.49 years (Median: 10, range = 4-19 years) and 97 patients (55.5 %) were male and 81 (45.5%) were female. Seventy-five patients (42.13%) were esotropes, 87 (48.87%) were exotropes and 16 (8.99%) were in combined deviation group. Hypermetropia (83/140, 59.28%) was the most common type of refractive error among ametropes (140/178). Among the hypermetropes, 52 (62.7%) had esotropia and 25 (64.1%) of the myopes had exotropia. Further, 52 (69.3%) of the esotropes had hypermetropia but there was no such trend of error noticed among the exotropes (p value < 0.001, Chi-square test). There were 70 (39.32%) amblyopes in the study population, out of which 35 (50%) had esotropia (p value: 0.032, Chi-square test).

Conclusion:
Hypermetropia was the most common refractive error among the study population and hypermetropes were prone to have esotropia and vice-versa. Esotropia and hypermetropia were more common among amblyopes.
A Novel RAGE Modulator Induces Soluble RAGE to Reduce BACE1 Expression in Alzheimer's Disease
Authors: Baek Seung‐Hyun , Hong Suji , Kim Eunae , Park Sunyoung , Lee Minyoung , Park Jinsu , Cho Yoonsuk , Yoon Hyunjun , Kim Daeseung , Yun Youngkwang , Kim Youbin , Choi Yoonjung , Kang Keunsoo , Jung Sangyong , Kim Jun Pyo , Kim Eunha , Seo Sang Won , Jung Yong‐Keun , Jo Dong‐Gyu 
Published: January 2025

Abstractβ‐secretase (BACE1) is instrumental in amyloid‐β (Aβ) production, with overexpression noted in Alzheimer's disease (AD) neuropathology. The interaction of Aβ with the receptor for advanced glycation endproducts (RAGE) facilitates cerebral uptake of Aβ and exacerbates its neurotoxicity and neuroinflammation, further augmenting BACE1 expression. Given the limitations of previous BACE1 inhibition efforts, the study explores reducing BACE1 expression to mitigate AD pathology. The research reveals that the anticancer agent 6‐thioguanosine (6‐TG) markedly diminishes BACE1 expression without eliciting cytotoxicity while enhancing microglial phagocytic activity, and ameliorate cognitive impairments with reducing Aβ accumulation in AD mice. Leveraging advanced deep learning‐based tool for target identification, and corroborating with surface plasmon resonance assays, it is elucidated that 6‐TG directly interacts with RAGE, modulating BACE1 expression through the JAK2‐STAT1 pathway and elevating soluble RAGE (sRAGE) levels in the brain. The findings illuminate the therapeutic potential of 6‐TG in ameliorating AD manifestations and advocate for small molecule strategies to increase brain sRAGE levels, offering a strategic alternative to the challenges posed by the complexity of AD.
High‐Throughput Formation of Pre‐Vascularized hiPSC‐Derived Hepatobiliary Organoids on a Chip via Nonparenchymal Cell Grafting
Authors: Fan Han , Shang Jia , Li Junbo , Yang Bo , Zhou Ding , Jiang Shanqing , Fan Yuhang , Zhou Ying , Wang Yuwen , Liu Peidi , Li Changyong , Chen Zhishui , Chen Pu 
Published: January 2025

AbstractLiver organoids have been increasingly adopted as a critical in vitro model to study liver development and diseases. However, the pre‐vascularization of liver organoids without affecting liver parenchymal specification remains a long‐lasting challenge, which is essential for their application in regenerative medicine. Here, the large‐scale formation of pre‐vascularized human hepatobiliary organoids (vhHBOs) is presented without affecting liver epithelial specification via a novel strategy, namely nonparenchymal cell grafting (NCG). Endothelial and mesenchymal cells are grafted to human hepatobiliary organoids (hHBOs) at the different liver epithelial differentiation stages without supplementing with nonparenchymal culture medium and growth factors. Endothelial grafting at the stage of hepatic maturation offers an optimal integration efficiency compared to the stage of hepatic specification. Additionally, grafting with mesenchymal proves crucial in endothelial invading and sprouting into the liver epithelial cells during the establishment of vhHBOs. Ectopic liver implants into mice further displayed integration of vhHBOs into mice vascular networks. Notably, transplanted vhHBOs self‐organized into native liver tissue like hepatic zone and bile ducts, indicating their potential to regenerate damaged hepatic and bile duct tissues. It is believed that nonparenchymal cell grafting will offer a novel technical route to form a high‐fidelity complex in vitro model for tissue engineering and regenerative medicine.
Engineered MSC‐sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis
Authors: Feng Kai , Liu Jiashuo , Gong Liangzhi , Ye Teng , Chen Zhengsheng , Wang Yang , Li Qing , Xie Xuetao 
Published: January 2025

AbstractChondrocyte senescence is an important pathogenic factor causing osteoarthritis (OA) progression through persistently producing pro‐inflammatory factors. Mesenchymal stem cells‐derived small extracellular vesicles (MSC‐sEVs) have shown anti‐inflammatory effects in OA models, while persistent existence of senescent chondrocytes still promotes cartilage destruction. Therefore, improving the targeted elimination ability on senescent chondrocytes is required to facilitate the translation of MSC‐sEVs in OA treatment. In this study, versatile engineered MSC‐sEVs are developed to targetedly clear senescent chondrocytes and maintain cartilage metabolic homeostasis. Specifically, MSC‐sEVs are loaded with siRNA mouse double minute 2 homologue (siMDM2) and modified with cartilage‐targeting peptide WYRGRL‐PEG2K‐DSPE (WPD), named WPD‐sEVssiMDM2. The results demonstrate versatile modification improves the cellular uptake of MSC‐sEVs in chondrocytes, and thus improves the antiaging effects. Importantly, multifunctional modification enhances cartilage penetration ability and extends joint retention time of MSC‐sEVs. In both post‐traumatic OA mice and naturally aged mice, WPD‐sEVssiMDM2 more effectively eliminates senescent chondrocytes and maintained matrix metabolic homeostasis. By using the P53 phosphorylation inhibitor, the essential role MDM2‐P53 pathway in the antiaging function of WPD‐sEVssiMDM2 on chondrocytes is verified. In ex vivo cultured human OA cartilage explants, it is confirmed that WPD‐sEVssiMDM2 alleviates senescent phenotype. Altogether, the findings suggest that WPD‐sEVssiMDM2 have promising translational potential for OA treatment.
Unipolar Barrier Photodetectors Based on Van Der Waals Heterostructure with Ultra‐High Light On/Off Ratio and Fast Speed
Authors: Wang Suofu , Wang Xiuxiu , Wang Wenhui , Han Tao , Li Feng , Shan Lei , Long Mingsheng 
Published: January 2025

AbstractUnipolar barrier architecture is designed to enhance the photodetector's sensitivity by inducing highly asymmetrical barriers, a higher barrier for blocking majority carriers to depressing dark current, and a low minority carrier barrier without impeding the photocurrent flow through the channel. Depressed dark current without block photocurrent is highly desired for uncooled Long‐wave infrared (LWIR) photodetection, which can enhance the sensitivity of the photodetector. Here, an excellent unipolar barrier photodetector based on multi‐layer (ML) graphene (G) is developed, WSe2, and PtSe2 (G‐WSe2‐PtSe2) van der Waals (vdW) heterostructure, in which extremely low dark current of 1.61×10−13 A, a record high light on/off ≈109 are demonstrated at 0 V. Notably, the device exhibits ultrafast response speed with rise time τr = 699 ns and decay time τd = 452 ns and high‐power conversion efficiency (η) of 4.87%. The heterostructure demonstrates a broadband photoresponse from 365 nm to LWIR 10.6 µm at room temperature. Notably, the G‐WSe2‐PtSe2 nBn device demonstrates high photoresponsivity (R) of 1.8 AW−1 with 10.6 µm laser at 1 V bias in ambient air. This unipolar barrier device architecture offers an alternative way for highly sensitive free space communication.
Clinical impact of low fornix perfusion on devascularized whole stomach as a risk factor for anastomotic leakage after esophagectomy
Authors: Takahashi Keita , Yuda Masami , Ishikawa Yoshitaka , Masuda Takahiro , Kurogochi Takanori , Fukushima Naoko , Matsumoto Akira , Tsuboi Kazuto , Nishikawa Katsunori , Yano Fumiaki , Eto Ken 
Published: January 2025

AbstractBackgroundsWe previously reported poor vascularity of narrow gastric tube evaluated by thermography was associated with anastomotic leakage (AL) after esophagectomy. Meanwhile, the association between the fornix low perfusion on devascularized whole stomach (DWS) and the incidence of AL remains unclear. Therefore, this study aimed to clarify the impact of the fornix low perfusion on DWS.MethodsA total of 238 patients who underwent Mckeown esophagectomy with gastric tube reconstruction between 2008 and 2021 were analyzed. Patients were divided into non‐AL and AL groups and their clinical outcomes including vascular factors of DWS and gastric tube were compared. Additionally, the logistic regression analysis was conducted to detect the risk factors of AL.ResultsAL occurred in 31 patients (13.0%). Regarding vascular factors, avascular area temperature retain rate (Av‐TRr) on DWS, right gastroepiploic artery length rate and anastomotic viability index (AVI) on gastric tube were significantly smaller in the AL group than in the non‐AL group. In logistic regression model for AL, multivariate analysis showed that diabetes (Odds ratio [OR], 3.90; 95% confidence interval [CI], 1.32–11.60), hand‐sewn anastomosis (OR, 4.42;95% CI, 1.05–18.60), Av‐TRr on DWS<0.91 (OR, 4.67; 95% CI, 2.00–10.90), and AVI<0.64 (OR, 2.68; 95% CI, 1.12–6.39) were significant risk factors.ConclusionsFornix low perfusion on DWS was a risk factor of AL as well as low AVI on gastric conduit. Additionally, fornix low perfusion on DWS was correlated with low AVI on gastric conduit.
Novel Fluoroquinolones With Pinane Moiety: Synthesis and Antimicrobial Activity
Authors: Gilfanov Ilmir R. , Kolesnikova Alyona I. , Pavelyev Roman S. , Sudarikov Denis V. , Gribkov Pavel V. , Izmest'ev Evgeniy S. , Rubtsova Svetlana A. , Lisovskaya Svetlana A. , Babaeva Olga B. , Rakhmatullin Ilfat Z. , Davletshin Rustam R. , Klochkov Vladimir V. , Nikitina Liliya E. , Kayumov Airat R. , Trizna Elena Y. 
Published: January 2025

ABSTRACTHere, we report a synthesis of fluoroquinolones carrying a monoterpene moiety at the C7 position of aromatic structure. The minimal inhibitory concentrations of fluoroquinolone fused with trans‐3‐hydroxy‐cis‐myrtanylamine 18 against Staphylococcus aureus (MSSA isolates) were two‐ to eightfold lower compared to moxifloxacin, although fourfold higher against MRSA isolates. The fluoroquinolone fused with (−)‐nopylamine 16 was four‐ to eightfold less active on MSSA compared to moxifloxacin, while had similar activity on MRSA. Against biofilms, both 16 and 18 were four times more active than both moxifloxacin and ciprofloxacin. Both 16 and 18 induced the drop of membrane potential and in silico exhibited similar binding energies with DNA gyrase of S. aureus (ΔG −13.44 to −13.17 kcal/mol), suggesting dual mechanism of action (topoisomerase inhibition by the fluoroquinolone core and membrane damage by the monoterpene fragment). Thus, our data demonstrate the perspectives of monoterpenes fusion to an antibiotic moiety to obtain dual‐acting bipharmacophore antimicrobials with improved activity, including biofilm‐associated infections.
Shared Governance and ESG Rating: Evidence From Korea
Authors: Jo Hoje , Chun Hongmin , Song Hakjoon 
Published: January 2025

ABSTRACTThis paper examines how shared governance structure affects firms' ESG rating using unique co‐CEO data in Korea for 2012–2019. We argue that coordination issues, interpersonal conflicts, and mutual monitoring of cosmetic ESG activities under the co‐CEO structure would decrease ESG ratings. Consistent with the premise, we find that co‐CEO firms disclose lower ESG ratings, especially social scores, than firms led by solo CEOs. However, Korean business group Co‐CEOs disclose higher ESG ratings due to reputation concerns, insurance benefits, and responsibility toward society. We further find that the negative association between co‐CEO structure and ESG rating is more pronounced in firms with low cash holding and high product market competition. We perform 2SLS estimation, PSM sample analyses, and entropy balancing approach to address possible endogeneity concerns along with self‐selection bias problems, and the results reinforce our main findings.
Impacts of City Life on Nutrition: Evidence From Resettlement Lotteries in China
Authors: Leng Ganxiao , Qiu Huanguang , Filipski Mateusz 
Published: January 2025

ABSTRACTUrban environments are thought to improve food security, by offering enhanced access to markets and income opportunities. Yet this idea is hard to test empirically due to an abundance of confounding factors and selection issues. This study leverages a resettlement program in China to provide the first quasi‐experimental estimate of city life on food consumption and nutrition among low‐income households. Lottery‐determined timing of resettlement enables causal inference. We base our empirics on a 3‐year panel and a range of difference‐in‐differences and matching methodologies. We find that those who were resettled to towns significantly increased both food consumption and diet variety, with increased intake of several macro‐ and micro‐nutrients. Diet quality mostly improved, but we also found signs of over‐consumption, notably of carbohydrates. Our evidence further suggests that our impacts are primarily due to improved market access. This stands in contrast to recent literature that finds little or no effect of living environments on food consumption. Instead, we reveal a significant impact of urban environments in shaping diets, bolstering the notion that supply‐side channels do matter in some contexts.
Cancer‐Associated Fibroblast‐Secreted Exosomes Regulate Macrophage Polarization in Pancreatic Cancer via the NOD1 Pathway
Authors: Yang Wenxin , Zheng Yuanyuan , Zhou Han , Liang Ruolong , Hu Chaofeng 
Published: January 2025

ABSTRACTMetastasis is a major cause of poor prognosis of pancreatic cancer. Exosomes (Exos) regulate cancer progression by modulating macrophage polarization. This study aimed to investigate the effects of cancer‐associated fibroblast (CAF)‐released Exos on macrophage polarization in pancreatic cancer and the molecular mechanisms. THP‐1 cells or xenografted tumor mice were treated with Exos from CAFs, and macrophage polarization was analyzed using quantitative real‐time PCR (qPCR) and flow cytometry. THP‐1 cells were cocultured with BXPC‐3 cells, and metastasis was analyzed using Transwell assay and scratch test. Exosomal PTGS2 was detected using qPCR, and the NOD1 pathway was evaluated using western blot analysis. The results showed that Exos promoted M2‐type polarization and inhibited M1‐type polarization, and then facilitated pancreatic cancer cell migration, invasion, and epithelial‐mesenchymal transition. PTGS2 expression was increased in Exo‐treated macrophages, and its knockdown in CAFs facilitated M2 to M1 macrophage polarization. Moreover, Exos promoted the NOD1 pathway via PTGS2, and inhibition of NOD1 reversed the polarization caused by Exos. Additionally, NOD1 was required in M1/M2 polarization in vivo mediated by Exos. In conclusion, CAF‐secreted Exos facilitated M2 macrophage polarization by carrying PTGS2 to activate the NOD1 pathway, thereby promoting pancreatic cancer metastasis, providing evidence that CAF‐Exos accelerating pancreatic cancer progression.