bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of the Impact of Environmental Disturbances on Forest Biomass in Taiwan
Authors: Chen Yi‐Ying , Huang Wei , Cheng Chao‐Tzuen , Hong Jing‐Shan , Yeh Fang‐Li , Luyssaert Sebastiaan 
Published: March 2022

AbstractThis study seeks to understand the impact on the forest biomass of different kinds of environmental disturbance, including high winds from typhoons, land‐use/land‐cover changes (LULCC), and CO2 fertilization. A series of factorial experiments addressing the impact of different types of environmental disturbance on the forest biomass in Taiwan was conducted using the advanced ORCHIDEE‐CAN land surface model with a recently developed wind‐throw module. The climatic forcing driving the ORCHIDEE‐CAN land surface model was first simulated by an atmospheric general circulation model, then dynamically downscaled to a more satisfactory spatial and temporal resolution. The initial and boundary conditions applied in the numerical simulations were based on the long‐term CO2 concentration and LULCC reconstruction, respectively. The model simulation showed an increase in the aboveground wood volume from 209 m3 ha−1 in 1979 to 229 m3 ha−1 in 2017, and the dynamics were consistent with those recorded in the national forest inventory. The annual average carbon sequestration rate over the past 39 years was 0.5 m3 ha−1 yr−1 for a forested area of 2.4 M ha. The most surprising finding was the contribution of the wind disturbance to wood loss, which was at almost the same level as the annual carbon sequestration rate. The LULCC experiment showed a trade‐off between afforestation and deforestation in forest biomass accumulation in Taiwan from 1979 to 2017. The CO2 fertilization effect contributed to an enhancement of forest biomass stock of around 39%, while the CO2 concentration increased from 296 to 406 ppm over 39 years.
Atmospheric River Storm Flooding Influences Tidal Marsh Elevation Building Processes
Authors: Thorne Karen , Jones Scott , Freeman Chase , Buffington Kevin , Janousek Christopher , Guntenspergen Glenn 
Published: March 2022

AbstractDisturbances are a key component of ecological processes in coastal ecosystems. Investigating factors that affect tidal marsh accretion and elevation change is important, largely due to accelerating sea‐level rise and the ecological and economic value of wetlands. Sediment accumulation rates, elevation change, and flooding were examined at five marshes along a riverine‐tidal gradient in the northern San Francisco Bay‐Delta, California, USA during an Atmospheric River storm event in 2017 using Surface Elevation Tables (SETs), feldspar marker horizons (MH), and continuous water‐level sensors. Our results showed that localized marsh flooding increased during the storm event, but not evenly across sites. Marsh surface elevation increased the most at the tidal freshwater marsh site in response to the storms, with an average surface elevation gain of 45.6 ± 13.1 mm, and the least at a tidal saline marsh with an average surface elevation gain of 4.0 ± 1.2 mm. A marsh located on the large embayment did not exhibit an immediate response to the storm but had a surface elevation gain of 21.5 ± 13.7 mm 6 months after the storm. During the storm period, marsh distance to the bay was the strongest predictor of elevation change, followed by SET‐MH elevations. Conversely, during non‐storm periods, SET‐MH elevation was a relatively strong predictor of elevation change. Atmospheric Rivers appear to be a major factor affecting short‐term spatial and temporal variability in flooding and sedimentation rates in tidal marsh systems. Incorporating information about storms into monitoring could increase our understanding of how episodic storms can impact marshes.
NARX Neural Network Derivations of the Outer Boundary Radiation Belt Electron Flux
Authors: Landis D. A. , Saikin A. A. , Zhelavskaya I. , Drozdov A. Y. , Aseev N. , Shprits Y. Y. , Pfitzer M. F. , Smirnov A. G. 
Published: March 2022

AbstractWe present two new empirical models of radiation belt electron flux at geostationary orbit. GOES‐15 measurements of 0.8 MeV electrons were used to train a Nonlinear Autoregressive with Exogenous input (NARX) neural network for both modeling GOES‐15 flux values and an upper boundary condition scaling factor (BF). The GOES‐15 flux model utilizes an input and feedback delay of 2 and 2 time steps (i.e., 5 min time steps) with the most efficient number of hidden layers set to 10. Magnetic local time, Dst, Kp, solar wind dynamic pressure, AE, and solar wind velocity were found to perform as predicative indicators of GOES‐15 flux and therefore were used as the exogenous inputs. The NARX‐derived upper boundary condition scaling factor was used in conjunction with the Versatile Electron Radiation Belt (VERB) code to produce reconstructions of the radiation belts during the period of July–November 1990, independent of in‐situ observations. Here, Kp was chosen as the sole exogenous input to be more compatible with the VERB code. This Combined Release and Radiation Effects Satellite‐era reconstruction showcases the potential to use these neural network‐derived boundary conditions as a method of hindcasting the historical radiation belts. This study serves as a companion paper to another recently published study on reconstructing the radiation belts during Solar Cycles 17–24 (Saikin et al., 2021, https://doi.org/10.1029/2020sw002524), for which the results featured in this paper were used.
Extreme Sea Level Estimation Combining Systematic Observed Skew Surges and Historical Record Sea Levels
Authors: Saint Criq Laurie , Gaume Eric , Hamdi Yasser , Ouarda Taha B. M. J. 
Published: March 2022

AbstractThe estimation of sea levels corresponding to high return periods is crucial for coastal planning and for the design of coastal defenses. This paper deals with the use of historical observations, that is, events that occurred before the beginning of the systematic tide gauge recordings, to improve the estimation of design sea levels. Most of the recent publications dealing with statistical analyses applied to sea levels suggest that astronomical high tide levels and skew surges should be analyzed and modeled separately. Historical samples generally consist of observed record sea levels. Some extreme historical skew surges can easily remain unnoticed if they occur at low or moderate astronomical high tides and do not generate extreme sea levels. The exhaustiveness of historical skew surge series, which is an essential criterion for an unbiased statistical inference, can therefore not be guaranteed. This study proposes a model combining, in a single Bayesian inference procedure, information of two different natures for the calibration of the statistical distribution of skew surges: measured skew surges for the systematic period and extreme sea levels for the historical period. A data‐based comparison of the proposed model with previously published approaches is presented based on a large number of Monte Carlo simulations. The proposed model is applied to four locations on the French Atlantic and Channel coasts. Results indicate that the proposed model is more reliable and accurate than previously proposed methods that aim at the integration of historical records in coastal sea level or surge statistical analyses.
LncRNA GACAT2 binds with protein PKM1/2 to regulate cell mitochondrial function and cementogenesis in an inflammatory environment
Authors: Li Xuan , Tian Bei-Min , Deng Dao-Kun , Liu Fen , Zhou Huan , Kong De-Qin , Qu Hong-Lei , Sun Li-Juan , He Xiao-Tao , Chen Fa-Ming 
Published: March 2022

AbstractPeriodontal ligament stem cells (PDLSCs) are a key cell type for restoring/regenerating lost/damaged periodontal tissues, including alveolar bone, periodontal ligament and root cementum, the latter of which is important for regaining tooth function. However, PDLSCs residing in an inflammatory environment generally exhibit compromised functions, as demonstrated by an impaired ability to differentiate into cementoblasts, which are responsible for regrowing the cementum. This study investigated the role of mitochondrial function and downstream long noncoding RNAs (lncRNAs) in regulating inflammation-induced changes in the cementogenesis of PDLSCs. We found that the inflammatory cytokine-induced impairment of the cementogenesis of PDLSCs was closely correlated with their mitochondrial function, and lncRNA microarray analysis and gain/loss-of-function studies identified GACAT2 as a regulator of the cellular events involved in inflammation-mediated mitochondrial function and cementogenesis. Subsequently, a comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) and parallel reaction monitoring (PRM) assays revealed that GACAT2 could directly bind to pyruvate kinase M1/2 (PKM1/2), a protein correlated with mitochondrial function. Further functional studies demonstrated that GACAT2 overexpression increased the cellular protein expression of PKM1/2, the PKM2 tetramer and phosphorylated PKM2, which led to enhanced pyruvate kinase (PK) activity and increased translocation of PKM2 into mitochondria. We then found that GACAT2 overexpression could reverse the damage to mitochondrial function and cementoblastic differentiation of PDLSCs induced by inflammation and that this effect could be abolished by PKM1/2 knockdown. Our data indicated that by binding to PKM1/2 proteins, the lncRNA GACAT2 plays a critical role in regulating mitochondrial function and cementogenesis in an inflammatory environment.
Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma
Authors: Nijhuis Anke , Sikka Arti , Yogev Orli , Herendi Lili , Balcells Cristina , Ma Yurui , Poon Evon , Eckold Clare , Valbuena Gabriel N. , Xu Yuewei , Liu Yusong , da Costa Barbara Martins , Gruet Michael , Wickremesinghe Chiharu , Benito Adrian , Kramer Holger , Montoya Alex , Carling David , Want Elizabeth J. , Jamin Yann , Chesler Louis , Keun Hector C. 
Published: March 2022

AbstractNeuroblastoma is the most common paediatric solid tumour and prognosis remains poor for high-risk cases despite the use of multimodal treatment. Analysis of public drug sensitivity data showed neuroblastoma lines to be sensitive to indisulam, a molecular glue that selectively targets RNA splicing factor RBM39 for proteosomal degradation via DCAF15-E3-ubiquitin ligase. In neuroblastoma models, indisulam induces rapid loss of RBM39, accumulation of splicing errors and growth inhibition in a DCAF15-dependent manner. Integrative analysis of RNAseq and proteomics data highlight a distinct disruption to cell cycle and metabolism. Metabolic profiling demonstrates metabolome perturbations and mitochondrial dysfunction resulting from indisulam. Complete tumour regression without relapse was observed in both xenograft and the Th-MYCN transgenic model of neuroblastoma after indisulam treatment, with RBM39 loss, RNA splicing and metabolic changes confirmed in vivo. Our data show that dual-targeting of metabolism and RNA splicing with anticancer indisulam is a promising therapeutic approach for high-risk neuroblastoma.
Oxo dicopper anchored on carbon nitride for selective oxidation of methane
Authors: Xie Pengfei , Ding Jing , Yao Zihao , Pu Tiancheng , Zhang Peng , Huang Zhennan , Wang Canhui , Zhang Junlei , Zecher-Freeman Noah , Zong Han , Yuan Dashui , Deng Shengwei , Shahbazian-Yassar Reza , Wang Chao 
Published: March 2022

AbstractSelective conversion of methane (CH4) into value-added chemicals represents a grand challenge for the efficient utilization of rising hydrocarbon sources. We report here dimeric copper centers supported on graphitic carbon nitride (denoted as Cu2@C3N4) as advanced catalysts for CH4 partial oxidation. The copper-dimer catalysts demonstrate high selectivity for partial oxidation of methane under both thermo- and photocatalytic reaction conditions, with hydrogen peroxide (H2O2) and oxygen (O2) being used as the oxidizer, respectively. In particular, the photocatalytic oxidation of CH4 with O2 achieves >10% conversion, and >98% selectivity toward methyl oxygenates and a mass-specific activity of 1399.3 mmol g Cu−1h−1. Mechanistic studies reveal that the high reactivity of Cu2@C3N4 can be ascribed to symphonic mechanisms among the bridging oxygen, the two copper sites and the semiconducting C3N4 substrate, which do not only facilitate the heterolytic scission of C-H bond, but also promotes H2O2 and O2 activation in thermo- and photocatalysis, respectively.
Global profiling of regulatory elements in the histone benzoylation pathway
Authors: Wang Duo , Yan Fuxiang , Wu Ping , Ge Kexue , Li Muchun , Li Tingting , Gao Ying , Peng Chao , Chen Yong 
Published: March 2022

AbstractLysine benzoylation (Kbz) is a recently discovered post-translational modification associated with active transcription. However, the proteins for maintaining and interpreting Kbz and the physiological roles of Kbz remain elusive. Here, we systematically characterize writer, eraser, and reader proteins of histone Kbz in S. cerevisiae using proteomic, biochemical, and structural approaches. Our study identifies 27 Kbz sites on yeast histones that can be regulated by cellular metabolic states. The Spt-Ada-Gcn5 acetyltransferase (SAGA) complex and NAD+-dependent histone deacetylase Hst2 could function as the writer and eraser of histone Kbz, respectively. Crystal structures of Hst2 complexes reveal the molecular basis for Kbz recognition and catalysis by Hst2. In addition, we demonstrate that a subset of YEATS domains and bromodomains serve as Kbz readers, and structural analyses reveal how YEATS and bromodomains recognize Kbz marks. Moreover, the proteome-wide screening of Kbz-modified proteins identifies 207 Kbz sites on 149 non-histone proteins enriched in ribosome biogenesis, glycolysis/gluconeogenesis, and rRNA processing pathways. Our studies identify regulatory elements for the Kbz pathway and provide a framework for dissecting the biological functions of lysine benzoylation.
Atomic reconfiguration among tri-state transition at ferroelectric/antiferroelectric phase boundaries in Pb(Zr,Ti)O3
Authors: Fu Zhengqian , Chen Xuefeng , Nie Henchang , Liu Yanyu , Hong Jiawang , Hu Tengfei , Yu Ziyi , Li Zhenqin , Zhang Linlin , Yao Heliang , Xia Yuanhua , Gao Zhipeng , An Zheyi , Zhang Nan , Cao Fei , Cai Henghui , Zeng Chaobin , Wang Genshui , Dong Xianlin , Xu Fangfang 
Published: March 2022

AbstractPhase boundary provides a fertile ground for exploring emergent phenomena and understanding order parameters couplings in condensed-matter physics. In Pb(Zr1-xTix)O3, there are two types of composition-dependent phase boundary with both technological and scientific importance, i.e. morphotropic phase boundary (MPB) separating polar regimes into different symmetry and ferroelectric/antiferroelectric (FE/AFE) phase boundary dividing polar and antipolar dipole configurations. In contrast with extensive studies on MPB, FE/AFE phase boundary is far less explored. Here, we apply atomic-scale imaging and Rietveld refinement to directly demonstrate the intermediate phase at FE/AFE phase boundary exhibits a rare multipolar Pb-cations ordering, i.e. coexistence of antipolar or polar displacement, which manifests itself in both periodically gradient lattice spacing and anomalous initial hysteresis loop. In-situ electron/neutron diffraction reveals that the same parent intermediate phase can transform into either FE or AFE state depending on suppression of antipolar or polar displacement, coupling with the evolution of long-/short-range oxygen octahedra tilts. First-principle calculations further show that the transition between AFE and FE phase can occur in a low-energy pathway via the intermediate phase. These findings enrich the structural understanding of FE/AFE phase boundary in perovskite oxides.
Sex differences in the association of postural control with indirect measures of body representations
Authors: Schulleri Katrin H. , Johannsen Leif , Michel Youssef , Lee Dongheui 
Published: March 2022

AbstractBesides anthropometric variables, high-order body representations have been hypothesised to influence postural control. However, this has not been directly tested before. Moreover, some studies indicate that sex moderates the relationship of anthropometry and postural control. Therefore, as a proof of concept we investigated the association of body representations with postural control as well as the influence of participants’ sex/gender. Body image measures were assessed with a figural drawing task. Body schema was tested by a covert and an overt task. Body sway was measured during normal bipedal quiet standing with eyes closed (with/without neck extended). Statistical analysis consisted of hierarchical multiple linear regressions with the following regression steps: (1) sensory condition, (2) sex/gender, (3) age, (4) anthropometry, (5) body schema, (6) body image, (7) sex/gender-interactions. Across 36 subjects (19 females), body schema was significantly associated with body sway variability and open-loop control, in addition to commonly known influencing factors, such as sensory condition, gender, age and anthropometry. While in females, also body image dissatisfaction substantially was associated with postural control, this was not the case in males. Sex differences and possible causes why high-order body representations may influence concurrent sensorimotor control of body sway are discussed.
The origin point of the unstable solution area of a forced softening Duffing oscillator
Authors: Wawrzynski Wojciech 
Published: March 2022

AbstractEach Duffing equation has an unstable solution area with a boundary, which is also a line of bifurcation. Generally, in a system that can be modeled by the Duffing equation, bifurcations can occur at frequencies lower than the origin point frequency of the unstable solution area for a softening system and at higher frequencies for a hardening system. The main goal of this research is to determine the analytical formulas for the origin point of the unstable solution area of a system described by a forced Duffing oscillator with softening stiffness, taking damping into account. To achieve this goal, two systems of softening Duffing oscillators that differ strongly in their nonlinearity factor value have been selected and tested. For each system, for three combinations of linear and nonlinear stiffness coefficients with the same nonlinearity factor, bistability areas and unstable solution areas were determined for a series of damping coefficient values. For each case, curves determined for different damping values were grouped to obtain the origin point curve of the unstable solution, ultimately developing the target formulas.
The role of PemIK (PemK/PemI) type II TA system from Klebsiella pneumoniae clinical strains in lytic phage infection
Authors: Bleriot Ines , Blasco Lucia , Pacios Olga , Fernández-García Laura , Ambroa Antón , López María , Ortiz-Cartagena Concha , Cuenca Felipe Fernández , Oteo-Iglesias Jesús , Pascual Álvaro , Martínez-Martínez Luis , Domingo-Calap Pilar , Wood Thomas K. , Tomás María 
Published: March 2022

AbstractSince their discovery, toxin-antitoxin (TA) systems have captivated the attention of many scientists. Recent studies have demonstrated that TA systems play a key role in phage inhibition. The aim of the present study was to investigate the role of the PemIK (PemK/PemI) type II TA system in phage inhibition by its intrinsic expression in clinical strains of Klebsiella pneumoniae carrying the lncL plasmid, which harbours the carbapenemase OXA-48 and the PemK/PemI TA system. Furthermore, induced expression of the system in an IPTG-inducible plasmid in a reference strain of K. pneumoniae ATCC10031 was also studied. The results showed that induced expression of the whole TA system did not inhibit phage infection, whereas overexpression of the pemK toxin prevented early infection. To investigate the molecular mechanism involved in the PemK toxin-mediated inhibition of phage infection, assays measuring metabolic activity and viability were performed, revealing that overexpression of the PemK toxin led to dormancy of the bacteria. Thus, we demonstrate that the PemK/PemI TA system plays a role in phage infection and that the action of the free toxin induces a dormant state in the cells, resulting in inhibition of phage infections.
High serum folate level is positively associated with pulmonary function in elderly Korean men, but not in women
Authors: Chang Suk Won , Kim Min Bum , Kang Ju Wan 
Published: March 2022

AbstractA limited number of studies have been conducted on the relationship between serum vitamin levels and pulmonary function, particularly in the elderly population. This study attempted to confirm the association between serum vitamin levels (folate, vitamin A, and vitamin E) and pulmonary function in the elderly population of Korea. A total of 1166 subjects (528 men and 637 women) participated in the Korean National Health and Nutrition Examination Survey from 2016 to 2018. Serum levels of folate, vitamin A, and vitamin E were measured in the subjects. The subjects’ pulmonary function measurement items were as follows: forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory volume in one second/forced vital capacity (FEV1/FVC), forced expiratory flow at 25% and 75% of the pulmonary volume (FEF25–75%), forced expiratory volume in 6 s (FEV6), and peak expiratory velocity (PEV). We performed regression analysis considering FEV1, PEV, FVC, FEF25–75%, and FEV1/FVC and FEV6 as dependent variables. Serum vitamin A levels were not associated with pulmonary function. In elderly men, serum vitamin E levels were negatively correlated with FVC [B =  − 0.012, 95% confidence interval (CI) − 0.022 to − 0.003, p = 0.012] and FEV1 (B =  − 0.010, 95% CI − 0.115 to − 0.007, p = 0.028). We confirmed a positive correlation of the serum folate level with FEV1 (B = 0.017, 95% CI 0.004–0.030, p = 0.009), FEV1/FVC (B = 0.003, 95% CI 0.001–0.005, p = 0.007), and FEF25–75% (B = 0.031, 95% CI 0.010–0.053, p = 0.005) in elderly men. This study confirmed that high serum folate levels were positively associated with pulmonary function in elderly men in Korea. Further studies are needed to understand the longitudinal effect of folate and its biological mechanism in pulmonary function.