bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspectiva de la epidemiología de infección por virus zika en el embarazo y el feto mediante revisión bibliográfica
Authors: Alarcón Benítez Paula , Brito Acosta Andrea , Márquez Quintero Laura , Contecha Zuleta Mariangel , Silva Góngora Isabella , Martínez Zubiría Rosalba 
Published: March 2022

La enfermedad del virus del Zika se debe a la picadura del mosquitos del genero Aedes infectado por un virus de la familia Flavivirus, llamado virus Zika. El primer caso reportado de fiebre del Zika fue en un mono centinela rhesus en Uganda en 1947. Cuya manifestación clínica cursa con una sintomatología moderada o asintomática, es decir, con síntomas leves. La metodología de este artículo se basó en la revisión de bases bibliograficas: artículos científicos, periódicos y materiales suministrados por las páginas de salud, como SciELO, NEJM, NCBI, Redalyc, Dialnet y Refseek, se construyó una breve y caudalosa indagación de la epidemia causada por el Zika, la cual afecta tanto a la comunidad colombiana; con ello, se llevó acabo que la transmisión también se debe por los cambios climáticos, precipitaciones fluviales, altas temperaturas y estancamientos de agua, y que una de las poblaciones que presenta mayores problemas de salud son las mujeres en gestación y los fetos, por lo tanto, se establece como principal objetivo de la investigación analizar las patologías asociadas al virus del Zika en mujeres en gestación, y sus afectaciones al feto, diagnóstico y pronóstico de la enfermedad. La revisión permitió concluir que el feto y la mujer en gestación que presente el virus del Zika repercute directamente, ya que es productor de microcefalia en el bebé y otras complicaciones neurológicas. Lo que crea la necesidad de un seguimiento posnatal del bebé al cual la madre padeció del virus.
Effect of conventional retting of jute on the quality of water and jute fiber
Authors: Ali MR , Kabir M , Shawon MTS , Hussain MM , Islam MH , Alam M 
Published: March 2022

Jute is a natural fiber also known as golden fiber in Bangladesh. Jute fiber is commonly extracted from the plant after immersion in water bodies. The traditional jute retting process harms the quality of jute fiber as well as water where jute plants were immersed as it decomposes bio-mass and hampers different water quality indicating parameters. In this study water samples were collected from different ponds and ditches at Muktagacha Upazilla, Mymensingh, Bangladesh in July 2020. Samples were collected from jute pre- and post-retting water bodies. The study was conducted to monitor the effect of jute retting on various physicochemical and microbiological parameters like- pH, total dissolved solids (TDS), electrical conductivity (EC), and dissolved oxygen (DO). All parameters were measured at the central laboratory of Bangladesh Agricultural University using a Multiparameter waterproof meter with a probe. To examine water quality, water samples were collected three times from five particular water bodies of stagnant waters, and the freshwater of the canal and pond. Water quality parameters of pre and post-retting jute water were found as pH 6.42~7.02 and 6.10~5.59, TDS 18~81 mgL-1and 103~183 mgL-1, DO 2.3~2.4 mgL-1and 0.8~0.9 mgL-1, and EC 36~163 µScm-1and 222~396 µScm-1, respectively. A comparison was made with the standard values of water quality parameters and found notable differences with the Department of Environment standards of Bangladesh. Another observation was also made to determine whether the retting water can influence fiber quality or not. Observed results indicated that a low level of pH and DO in jute retted water in a pond may not be suitable for fish cultivation. On the other hand, higher content of TDS and EC in post jute retting water was found responsible for the poor quality of jute fiber.
Progressive Agriculture 32 (2): 151-161, 2021
HUBUNGAN UMUR, TINGKAT PENDIDIKAN DAN PENDAPATAN DENGAN KEPUASAN PENGUNJUNG WISATA PANTAI MEMBUKU DI KABUPATEN BUTON UTARA
Authors: Yusdin - , Budiyanto - , Rosmawati - 
Published: March 2022

ABSTRAKSalah satu wisata alam yang sampai saat ini masih diminati oleh pengunjung di Kabupaten Buton Utara adalah wisata Pantai Membuku.Wisatawan yang datang di pantai tersebut terdiri dari berbagai latar belakang mulai dari umur, tingkat pendidikan dan pendapatan yang diduga akan mempengaruhi tanggapan wisatawan terhadap kepuasan wisata di pantai ini. Tujuan penelitian ini adalah untuk mengetahui hubungan umur, tingkat pendidikan dan pendapatan dengan tingkat kepuasan pengunjung. Penelitian ini dilakukan selama periode Maret Sampai April 2020. Populasi dalam penelitian ini adalah semua pengunjung pada objek wisata sedangkan sampel dipilih menggunakan metode accidental sampling sebanyak 50 wisatawan. Analisis data menggunakan analisis korelasi pearson dengan menggunakan aplikasi Microsoft Excel 2007. Hasil analisis menunjukkan bahwa variabel umur dengan tingkat kepuasan pengunjung wisata pantai Membuku memiliki nilai koefisien korelasi sebesar 0,98 artinya variabel umur dengan tingkat kepuasan pengunjung memiliki hubungan yang sangat kuat karena nilai koefisien korelasinya mendekati angka satu, begitu juga sebaliknya jika nilai koefisien korelasinya mendekati angka nol berarti kedua variabel tersebut sangat lemah. Nilai koefisien korelasi variabel tingkat pendidikan dengan tingkat kepuasan pengunjung wisata Pantai Membuku sebesar 0,99 artinya variabel tingkat pendidikan dengan tingkat kepuasan pengunjung memiliki hubungan yang sangat kuat, sedangkan hubungan variabel pendapatan dengan tingkat kepuasan pengunjung wisata pantai Membuku memiliki nilai koefisien korelasi sebesar 0,60 artinya antara variabel pendapatan dengan tingkat kepuasan pengunjung memiliki hubungan yang kuat. Artinya semakin tinggi pendapatan wisatawan maka akan semakin tinggi pula nilai koefisien korelasinya. Oleh karena itu pihak pengelola harus meningkatkan kualitas fasilitas objek wisata agar berkelanjutan dan bisa mendapatkan penilaian yang lebih bagus lagi dari wisatawan yang berkunjung di Pantai Membuku sebelumnya. Kata kunci : Tingkat Kepuasan, Umur, Pendidikan, Pendapatan, Pantai Membuku
STRATEGI PENGEMBANGAN WISATA PANTAI BATU GONG DI DESA BATU GONG KECAMATAN LALONGGASUMEETO KABUPATEN KONAWE
Authors: Thayeb Jusran , Lawelle Sjamsu Alam , Rosmawati - 
Published: March 2022

ABSTRAK Penelitian ini bertujuan untuk mengetahui strategi pengembangan wisata pantai Batu Gong di Desa Batu Gong Kecamatan Lalonggasumeeto Kabupaten Konawe, yang dilaksanakan pada bulan Oktober sampai November 2019. Pemilihan lokasi penelitian dilakukan secara purposive. Tehnik pengambilan sampel digunakan pada penelitian ini menggunakan dua metode yaitu accidential sampling dan purposive sampling. Analisis data yang digunakan dalam penelitian ini adalahanalisis SWOT yang bertujuan untuk melihat kekuatan, kelemahan, peluang dan ancaman.Hasil analisis bahwa strategi pengembangan pantai Batu Gong adalah (S-O) memanfaatkan lokasi mudah diakses wisatawan serta menambah fasilitas untuk menarik minat masyarakat untuk berkunjung, memanfaatkan lokasi yang membentang luas yang dapat digunakan sebagai lapangan pekerjaan sehingga dapat meningkatkan perekonomian masyarakat setempat, memanfaatkan teknologi media sosial dan media cetak untuk memperkenalkan objek wisata, dan memanfaatkan hubungan baik dengan seluruh stakeholderuntuk meningkatkan penyediaan fasilitas. (S-T) meningkatkan keamanan untuk menghindari terjadinya tindak kriminal pada wisatawan dan emanfaatkan lokasi yang mudah dijangkau, fasilitas yang tersedia sebagai keunggulan objek wisata dari pesaing objek wisata lain. (W-O) meningkatkan hubungan melalui kerja sama yang baik dengan stackholder terkait pengelolaan kebersihan pantai, penataan serta persediaan gazebo dan meningkatkan kegiatan promosi di media sosial dan media cetak untuk memperkenalkan objek wisata. (W-T) meningkatkan kebersihan pantai dan pengontrolan dari pihak berwajib untuk mengurangi resiko tawuran/perkelahian dan tindak kriminal. Kata Kunci : Pengembangan, Wisata, Pantai
Association of Impaired Fasting Blood Glucose With Triple Coronary Artery Stenosis and Myocardial Infarction Among Patients With Coronary Artery Stenosis
Authors: Chen Chang , Chen Yequn , Xiao Jiaxin , Zhang Yanhong , Yang Zhaorui , Yang Peixuan , Lu Nan , Yi Kaihong , Chen Xiaojun , Chen Shaoxin , O'Gara MSc Mary Clare , O'Meara Michael , Ye Shu , Tan Xuerui 
Published: March 2022

Background: The association between impaired fasting glucose level (IFG) and coronary heart disease (CAD) remain controversial. In the present study, we sought to ascertain a relationship of IFG with the number of diseased coronary artery and occurrence of myocardial infarction, among CAD cases.Methods: We studied 1,451 consecutive no-diabetic patients who underwent coronary angiography at the First Affiliated Hospital of Shantou University Medical College in Southern China. Demographic, biochemical, clinical and angiographic data were collected.Results: The prevalence of IFG was higher in patients with angiographically confirmed CAD than in subjects without angiographic evidence of CAD (33.4 versus 28.2%, p = 0.034). Compared with CAD cases without IFG, CAD cases with IFG had a higher odds ratio (OR) of having triple-vessel disease as opposed to having single- or double-vessel disease [OR = 1.53, 95% confidence interval (CI) = 1.13–2.07]. Furthermore, the occurrence of MI was higher in CAD cases with IFG than in CAD cases without IFG (OR = 1.73, 95% CI = 1.27–2.36).Conclusions: There is an association between IFG and a predisposition to severe CAD indicated by triple vessel disease or myocardial infarction.
Prevalence and Mortality of Moderate or Severe Mitral Regurgitation Among Patients Undergoing Percutaneous Coronary Intervention With or Without Heart Failure: Results From CIN Study With 28,358 Patients
Authors: Huang Haozhang , Liu Jin , Bao Kunming , Huang Xiaoyu , Huang Dehua , Wei Haiyan , Remutula Nuerbahaer , Tuersun Tilakezi , Lai Wenguang , Li Qiang , Wang Bo , He Yibo , Yang Heyin , Chen Shiqun , Chen Jiyan , Chen Kaihong , Tan Ning , Wang Xiaoyan , Chen Liling , Liu Yong 
Published: March 2022

AimThis study investigated the prevalence and mortality associated with moderate or severe mitral regurgitation (MR) among patients undergoing percutaneous coronary intervention (PCI), with or without heart failure (HF).MethodsWe analyzed patients undergoing PCI without mitral valve surgery from the Cardiorenal ImprovemeNt (CIN) study (ClinicalTrials.gov NCT04407936). Patients without echocardiography to determine MR occurrence or lacking follow-up death data were excluded. Primary endpoints were 1-year and long-term all-cause mortality, with a median follow-up time of 5 years (interquartile range: 3.1–7.6).ResultsOf 28,358 patients undergoing PCI treatment [mean age: 62.7 ± 10.7; women: 6,749 (25.6%)], 3,506 (12.4%) had moderate or severe MR, and there was a higher rate of moderate or severe MR in HF group than non-HF group (28.8 vs. 5.6%, respectively). Regardless of HF conditions, patients with moderate or severe MR were older and had worse cardio-renal function and significantly increased 1-year mortality [adjusted hazard ratio (aHR): 1.82, 95% confidence interval (CI): 1.51–2.2], and long-term mortality [aHR: 1.43, 95% CI: 1.3–1.58]. There was no significant difference between patients with HF and those with non-HF (P for interaction &gt; 0.05).ConclusionOne-eighth of the patients undergoing PCI had moderate or severe MR. Furthermore, one-third and one-seventeenth experienced moderate or severe MR with worse cardiorenal function in the HF and non-HF groups, and increased consistent mortality risk. Further studies should explore the efficacy of mitral interventional procedures for moderate or severe MR after PCI treatment, regardless of HF.
Gender-Based Association of Coronary Artery Calcification and Framingham Risk Score With Non-alcoholic Fatty Liver Disease and Abdominal Obesity in Taiwanese Adults, a Cross-Sectional Study
Authors: Tsou Meng-Ting , Chen Jau-Yuan 
Published: March 2022

BackgroundIt is not certain whether non-alcoholic fatty liver disease (NAFLD) or abdominal obesity (AO) has stronger associations with atherosclerosis and coronary artery disease (CAD) risk across different genders. The purpose of this study was to determine the gender-based association of NAFLD and AO with subclinical atherosclerosis represented by coronary artery calcification (CAC) and CAD risk by Framingham risk score (FRS).MethodsA total of 1,655 participants in a health-screening program (mean age: 49.44 years; males: 70.33%) were enrolled for analysis. Fatty liver and coronary artery calcium score (CACS) were measured via ultrasonography (US) and multi-detector computed tomography (MDCT). The presence of CAC was defined as having a CACS &gt; 0, intermediate to high CAD risk was defined as FRS ≥ 10%, while the presence of AO was defined as having a waist circumference (WC) of ≥90 cm for men and ≥80 cm for women. Participants were categorized into four groups depending on the presence or absence of NAFLD and/or AO.ResultsThe percentage of subjects with CACS &gt; 0 was highest in the AO-only group (overall: 42.6%; men: 48.4%; women: 35.8%); and FRS ≥ 10% was highest in the group with both abnormalities (overall: 50.3%%; men: 57.3%; women: 32.4%). After adjustment factors, the odds ratio (OR) for CAC and FRS was the highest in the group with both abnormalities [men: 1.61 (1.13–2.30) for CACS &gt; 0 and 5.86 (3.37–10.20) for FRS ≥ 10%; women: 2.17 (1.13–4.16) for CACS &gt; 0 and 6.31 (2.08–19.10) for FRS ≥ 10%]. In men, the OR of NAFLD was higher than that of AO [1.37 (1.03–1.83) vs. 1.35 (1.02–1.79) for CACS &gt; 0, 3.26 (2.13–4.98) vs. 2.97 (1.91–4.62) for FRS ≥ 10%]. However, women with AO consistently showed increased OR for CACS &gt; 0 [1.87 (1.11–3.16)] and FRS ≥ 10% [4.77 (2.01–11.34)].ConclusionThe degree of association of NAFLD and AO with CAC and FRS depends on the gender. NAFLD is more closely associated with CACS &gt; 0 and FRS ≥ 10% in men and AO in women, respectively. NAFLD and AO could be considered independent determinants of CAC and FRS by gender.
Yedoma Cryostratigraphy of Recently Excavated Sections of the CRREL Permafrost Tunnel Near Fairbanks, Alaska
Authors: Kanevskiy Mikhail , Shur Yuri , Bigelow Nancy H. , Bjella Kevin L. , Douglas Thomas A. , Fortier Daniel , Jones Benjamin M. , Jorgenson M. Torre 
Published: March 2022

Recent excavation in the new CRREL Permafrost Tunnel in Fox, Alaska provides a unique opportunity to study properties of Yedoma — late Pleistocene ice- and organic-rich syngenetic permafrost. Yedoma has been described at numerous sites across Interior Alaska, mainly within the Yukon-Tanana upland. The most comprehensive data on the structure and properties of Yedoma in this area have been obtained in the CRREL Permafrost Tunnel near Fairbanks — one of the most accessible large-scale exposures of Yedoma permafrost on Earth, which became available to researchers in the mid-1960s. Expansion of the new ∼4-m-high and ∼4-m-wide linear excavations, started in 2011 and ongoing, exposes an additional 300 m of well-preserved Yedoma and provides access to sediments deposited over the past 40,000 years, which will allow us to quantify rates and patterns of formation of syngenetic permafrost, depositional history and biogeochemical characteristics of Yedoma, and its response to a warmer climate. In this paper, we present results of detailed cryostratigraphic studies in the Tunnel and adjacent area. Data from our study include ground-ice content, the stable water isotope composition of the variety of ground-ice bodies, and radiocarbon age dates. Based on cryostratigraphic mapping of the Tunnel and results of drilling above and inside the Tunnel, six main cryostratigraphic units have been distinguished: 1) active layer; 2) modern intermediate layer (ice-rich silt); 3) relatively ice-poor Yedoma silt reworked by thermal erosion and thermokarst during the Holocene; 4) ice-rich late Pleistocene Yedoma silt with large ice wedges; 5) relatively ice-poor fluvial gravel; and 6) ice-poor bedrock. Our studies reveal significant differences in cryostratigraphy of the new and old CRREL Permafrost Tunnel facilities. Original syngenetic permafrost in the new Tunnel has been better preserved and less affected by erosional events during the period of Yedoma formation, although numerous features (e.g., bodies of thermokarst-cave ice, thaw unconformities, buried gullies) indicate the original Yedoma silt in the recently excavated sections was also reworked to some extent by thermokarst and thermal erosion during the late Pleistocene and Holocene.
Projected 21st-Century Glacial Lake Evolution in High Mountain Asia
Authors: Furian Wilhelm , Maussion Fabien , Schneider Christoph 
Published: March 2022

In High Mountain Asia (HMA), rising temperatures and retreating glaciers are leading to the formation of new glacial lakes and the expansion of existing ones. The sudden release of water from such lakes can lead to devastating glacial lake outburst floods (GLOF) threatening people and infrastructure for many kilometers downstream. Therefore, information on future glacial lakes, e.g., their location, area and volume as well as the timing of their development, is vital for sustainable development of settlements and infrastructures. In this study, we present comprehensive estimates for future glacial lake development in HMA with unprecedented temporal resolution. We rely on an ensemble of fifteen global climate models using the newest CMIP6 data and employ a set of four Shared Socioeconomic Pathway (SSP) scenarios. With the Open Global Glacier Model (OGGM), we use a modeling framework that explicitly simulates glacier dynamics in order to model glacier change until 2100 and estimate the formation period for each of the 2,700 largest future glacial lakes (&gt;0.1 km2) in HMA. We estimate the glacial lake area in the entire region to grow by 474 ± 121 km2 for SSP126 and 833 ± 148 km2 for SSP585. Following recent estimates of currently existing glacial lakes (&gt;0.1 km2), this would constitute an increase in lake area of ∼120–∼210% in 2100 compared to 2018. The lake volume is expected to increase by 22.8 ± 6.7 km3 for SSP126 and 39.7 ± 7.7 km3 for SSP585. This range includes a drastic tenfold increase in lake volume, from estimated 3.9 km3 in 2018 to 43.6 ± 7.7 km3 in 2100. However, there is a considerable spread between total and relative increase in glacial lake area and volume for different sub-regions of High Mountain Asia. As both, lake area and lake volume, could to lead to an increase in GLOF risk, the results emphasize the urgent need for more localized, in-depth studies at especially vulnerable locations in order to enable local communities to adapt to emerging challenges, to implement risk minimization measures, and to improve sustainable development in High Mountain Asia.
The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6, and TNF-α Levels in Prediabetes
Authors: Huang Kangkang , Liang Yunlai , Ma Yating , Wu Jiahui , Luo Huidan , Yi Bin 
Published: March 2022

BackgroundThe variation and correlation among adiponectin, nesfatin-1, tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6), which may be involved in the development of the decline of health into prediabetes and diabetes, have not been elucidated. This study aims to investigate the roles of these cytokines in this process.MethodsSeventy-two type 2 diabetes mellitus (T2DM) patients, 75 prediabetics, and 72 healthy individuals were enrolled in our case control study. Serum adiponectin, nesfatin-1, TNF-α, and IL-6 were tested with appropriate kits, and primary data were analyzed with correct methods.ResultsSerum levels of each cytokine in patients with prediabetes were between T2DM and the healthy, and significant differences were found among them. TNF-α and nesfatin-1 levels in T2DM were obviously different compared to prediabetes or the healthy; IL-6 and adiponectin levels in the healthy group were significantly changed in contrast to prediabetes or T2DM. Correlation analysis found that in prediabetics, adiponectin was positively correlated with TNF-α (R = 0.2939, P = 0.0105) and IL-6 (R = 0.3918, P = 0.0005), and their relationship was greatly strengthened in prediabetes accompanied by insulin resistance (TNF-α: R = 0.7732, P &lt; 0.0001, IL-6: R = 0.6663, P = 0.0005). We also demonstrated that declined adiponectin (OR = 6.238, P = 0.019) and nesfatin-1 (OR = 2.812, P = 0.01) and elevated TNF-α (OR = 5.541, P = 0.001) were risk factors for prediabetes toward diabetes.ConclusionsThis research proved significant variations of adiponectin, nesfatin-1, IL-6, and TNF-α levels in the healthy, prediabetics, and T2DM, suggesting a slow and gradual change during the progression from a healthy condition toward diabetes via prediabetes.
FOXO1 Gene Downregulation and Promoter Methylation Exhibits Significant Correlation With Clinical Parameters in Indian Breast Cancer Patients
Authors: Khan Mohammad Aasif , Massey Sheersh , Ahmad Irfan , Sadaf  , Akhter Naseem , Habib Maria , Mustafa Saad , Deo S. V. S. , Husain Syed Akhtar 
Published: March 2022

Background: Forkhead box “O” one which is member of Forkhead box family of transcription factors is known to play key role in different physiological processes including cell cycle arrest, autophagy, and apoptosis. FOXO1 is defined to play tumor suppressive role in various malignancies including breast cancer and its Dysregulation is frequently reported. However, the evaluation of FOXO1 promoter methylation and its expression at mRNA and protein level in different stages of breast cancer and its association with different clinical parameters is still not studied. Therefore, for better understanding the role of FOXO1 in breast cancer, in our study we examined the FOXO1 mRNA and protein expression in Breast cancer samples of Indian breast cancer patients.Results: Total 127 breast cancer samples along with adjacent normal tissue (n = 127) were analyzed through methylation specific PCR (MS-PCR), mRNA expression (Real-time PCR) and Immunohistochemistry (IHC). We detected 69.29% cases to be downregulated at the mRNA level, and 77.95% of cases exhibited no or low protein expression. In our data we report a significant association (p = 0.0001) between the downregulated protein expression and promoter hypermethylation of FOXO1 gene. We also found a significant correlation of FOXO1 mRNA level with Age (p = 0.008), age at first live birth (p = 0,003), tumor size (p = 0.05) and lymph node status (p = 0.01).Conclusion: we in our study report the tumor suppressive role of FOXO1 in case of Indian breast cancer patients and our data suggest it to exhibit prognostic importance. However, further research is needed to evaluate FOXO1 significance in diagnostic and therapeutic targeting in breast cancer cases.