bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delineation of Bangladeshi coastal rice germplasm based on qualitative phenotypic traits
Authors: Banik Susmita , Rasul Md. Golam , Ivy Nasrin Akter , Haque M. Moynul , Hasan Mehfuz 
Published: May 2022

AbstractA detailed study of rice genetic resources in Bangladesh's coastal areas is necessary. This understanding is a necessary requirement for its utilization in selective breeding. The study reports on the qualitative morphological trait-based assessment of 150 local rice samples collected from Bangladesh's coastal zone, including 50 advanced lines developed from coastal germplasm. Six of the thirteen analysed characters had a substantial gene contribution, whereas the average was 0.694. The most impressive diversity was in leaf blade intensity of green colour (LBIGC: 0.705). The total morpho-qualitative diversity was calculated to be 0.412. The character efficiency content ranged from 0.655 (LBIGC) to 0.136 (Leaf Sheath: Anthocyanin colouration, Leaf Blade: Presence/Absence, and Leaf Blade: Anthocyanin. Colouration). As per the morphological variance study, 93% of morphological changes were detected within individuals, whereas 7% were found in populations. The 150 germplasm samples were divided into four subpopulations using STRUCTURE-based population analysis. A moderate genotypic difference was detected amongst all groups, with an Fst value of 0.111. The G statistic backed up the record as well. The Shannon mutual information index reached a value of 1.252 between populations 2 and 3. In terms of gene exchange, the highest value was found between populations 3 and 4. Our data indicate a high degree of diversity in Bangladesh's coastline rice germplasm. The findings will aid in conferring the farmers' Intellectual Property Rights on the investigated rice germplasm.
Work and Family Balance in Top Diplomacy: The Case of the Czech Republic
Authors: Fellegi Zuzana , Kočí Kateřina , Benešová Klára 
Published: May 2022

AbstractWhile female representation in the top diplomatic circles was almost nonexistent during the Czechoslovak era, the number of female diplomats in the Czech Republic has steadily increased since the fall of the state-socialist regime. Women are currently solidly represented in the Czech Ministry of Foreign Affairs (MFA), but very few (14%) reach highest diplomatic positions. This study examines the main challenges that influence the careers of top diplomats using quantitative and qualitative data, including official statistics and documents of the Czech MFA and interviews with top diplomats and officials. The results indicate that work-family conflicts are the main challenge for all diplomats. However, women are apparently affected more disproportionately because of the existing “double burden” and a specific “concept of motherhood” vested in a deeply essentialist understanding of gender roles. These barriers have origins at the personal, institutional, and state levels that are strongly interrelated and historically and politically path dependent.
Being Snoopy and Smart
Authors: Hartung Freda-Marie , Thieme Pia , Wild-Wall Nele , Hell Benedikt 
Published: May 2022

Abstract. Curiosity is a basic driver for learning and development. It has been conceptualized as a desire for new information and knowledge that motivates people to explore their physical and social environment. This raises the question of whether curiosity facilitates the acquisition of knowledge. The present study ( N = 100) assessed epistemic curiosity and general knowledge as well as fluid intelligence (i.e., reasoning ability, processing speed, memory) in a student sample. The results indicate that epistemic curiosity is moderately related to knowledge ( r = .24) and reasoning ability ( r = .30). None of the fluid intelligence measures did moderate the relationship between curiosity and knowledge (interaction terms β < |.08|). Rather, reasoning ability mediated the relationship between epistemic curiosity and general knowledge (indirect effect: β = .10, p < .05). The findings suggest that epistemic curiosity facilitates the acquisition of knowledge by promoting reasoning. One might speculate that epistemically curious individuals enrich their environment, which in turn enhances their cognitive ability.
The Sources, Molecular Compositions, and Light Absorption Properties of Water‐Soluble Organic Carbon in Marine Aerosols From South China Sea to the Eastern Indian Ocean
Authors: Mo Yangzhi , Zhong Guangcai , Li Jun , Liu Xin , Jiang Hongxing , Tang Jiao , Jiang Bin , Liao Yuhong , Cheng Zhineng , Zhang Gan 
Published: May 2022

AbstractWater‐soluble organic carbon (WSOC) is a substantial component of carbonaceous aerosols in South/East Asia. However, the poorly constrained sources, molecular compositions, and light absorption properties of WSOC over South/East Asian marine regions lead to large uncertainty in climate effects. Herein, we collected marine aerosol samples from South China Sea to the eastern Indian Ocean to investigate the sources, molecular compositions, and light absorption properties of WSOC. The δ13C of Marine‐influenced WSOC (−20.6 ± 1.4‰) was higher than those in Continent‐influenced (South Asia‐influenced: −24.4 ± 1.1‰ and Southeast Asia‐influenced: −22.7 ± 1.0‰, p < 0.01) regions. Additionally, combining with 5‐day back trajectories and the relationships of δ13C‐WSOC with chemical tracers (Cl−/Na+ and nonsea salt K+/K+), we found that the Marine‐influenced WSOC was mostly related to oceanic emissions, which was more enriched in saturated primary marine biological compounds with lower oxidation level. In contrast, the Continent‐influenced WSOC was significantly affected by C3 biomass burning and secondary organic aerosols formation, and it has a higher fraction of aromatic and highly oxidized compounds. Moreover, the high aromatic level of Continental‐influenced WSOC may result in high mass absorption efficiency at 365 nm (MAE365) but low absorption Ångström exponent (AAE) values. Taken together with previous WSOC light absorption properties studies, we found that the MAE365 of WSOC in urban, rural and background, and marine regions correlated well with AAE. However, the response and correlation coefficients of MAE365 to AAE were highest in urban regions, followed by rural and background and marine regions, which is likely associated with different aromatic compound contents. Therefore, in the future, more attention should be paid to the sources and atmospheric processes of condensed aromatic compounds.
The Study of Daytime Ionospheric E‐Region Radar Echoes Simultaneously Observed by Qujing VHF Radar and Multi‐Ionosondes
Authors: Zhu Yunzhou , Tang Qiong , Deng Zhongxin , Zhou Chen , Liu Yi , Xu Tong , Wang Zhuangkai , Zhao Zhengyu , Wei Fengsi , Feng Xueshang 
Published: May 2022

AbstractIn this work, the daytime E‐region field‐aligned irregularities (FAIs) observed by the Qujing (geographic 25.64°N, 103.70°E) Very High Frequency coherent backscatter radar was reported. The range spread and enhanced sporadic‐E layer (Es) during the same period of the unusual radar echoes were separately observed by two ionosondes located at the Huize and Qujing. The Huize (geographic 26.51°N, 103.61°E) ionosonde was roughly located underneath the radar scattering volume which measured enhanced and range spread Es layer during this period of the unusual radar echoes, indicating that the daytime E‐region FAIs were closely related to the localized density gradient that embedded within the coordinated Es layer. Fengyun‐4A (FY‐4A) satellite data show that a strong convective activity accompanied by gravity waves occurred near the radar scattering volume region. As a result, we proposed that the gravity waves driven by the convective activity in the lower atmosphere can modulate the Es layers and then generate the daytime FAIs through the polarization process.
Mapping a Magnetic Superstorm: March 1989 Geoelectric Hazards and Impacts on United States Power Systems
Authors: Love Jeffrey J. , Lucas Greg M. , Rigler E. Joshua , Murphy Benjamin S. , Kelbert Anna , Bedrosian Paul A. 
Published: May 2022

AbstractA study is made of the relations between geomagnetic and geoelectric field variation, Earth‐surface impedance, and operational interference (“anomalies”) experienced on electric‐power systems across the contiguous United States during the 13–14 March, 1989, magnetic storm. For this, a 1‐min‐resolution sequence of geomagnetic field maps is constructed from magnetometer time series acquired at ground‐based observatories. Induced geoelectric field maps are calculated by convolving the geomagnetic maps with magnetotelluric impedance tensors. During the storm, anomalies were concentrated where the lithosphere is electrically resistive, and when and where geoelectric field amplitudes were high. This was particularly true in the Mid‐Atlantic, Northeast, and the upper Midwest. Few anomalies were experienced in other parts of the Midwest and across much of the West, where the lithosphere is more conductive, and when and where geoelectric field amplitudes were low. Peak 1‐min‐resolution geoelectric field amplitude ranged from 21.66 V/km in Maine and 19.02 V/km in Virginia to <0.02 V/km in Idaho. Latitude‐dependent organization of geoelectric hazards by auroral‐zone electrojet currents is detectable, but it is much weaker than geographic organization due to surface impedance. Hazardous geoelectric fields were induced during different storm phases, at different local times, and, by inference, by a variety of ionospheric currents. Compared to geoelectric field amplitudes realized across the United States during March 1989, hazard maps used by utility companies to estimate systems exposure have much less geographic detail and a much smaller maximum‐to‐minimum range in geoelectric field amplitude. Future research would benefit from denser geomagnetic monitoring, additional magnetotelluric surveying, and access to power‐system impact data.
The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism
Authors: Zhu Ximei , Yan Wei , Lin Xiao , Que Jianyu , Huang Yuetong , Zheng Haohao , Liu Lin , Deng Jiahui , Lu Lin , Chang Suhua 
Published: May 2022

AbstractPerceived stress impairs cognitive function across the adult lifespan, but the extent to which cognition decline is variable across individuals. Individual differences in the stress response are described as personality traits. Substantial individual differences in the magnitude of cognitive impairment that is induced by short-term perceived stress are poorly understood. The present study tested the hypothesis that the relationship between short-term perceived stress and different aspects of cognition is mediated by personality traits. The study included 1066 participants with behavior and neuroimaging data from the Human Connectome Project after excluding individuals with missing variables. In the result, the parallel multiple mediation model demonstrated that the influence of perceived stress on the total and crystalized cognition is mainly mediated by neuroticism (indirect effect = −0.04, p < 0.05) and conscientiousness (indirect effect = 0.05, p < 0.05) in adults. Cortical thickness value (n = 1066) of the right superior frontal gyrus (SFG) showed not only positive correlations with short-term perceived stress and neuroticism, but negative associations with cognition. The chain mediation model found that the right SFG and neuroticism play a small but significant chain mediating effect between stress and total cognition. The strength of the resting-state functional connectivity (n = 968) between the left orbitofrontal cortex versus the left superior medial frontal cortex was positively correlated with crystallized cognition and negatively associated with conscientiousness. These results extend previous findings by the impacts of short-term perceived stress on cognitive function is mediated by neuroticism and the right SFG was the underlying neural mechanism.
Ferutinin induces osteoblast differentiation of DPSCs via induction of KLF2 and autophagy/mitophagy
Authors: Maity Jyotirindra , Barthels Derek , Sarkar Jaganmay , Prateeksha Prateeksha , Deb Moonmoon , Rolph Daniela , Das Hiranmoy 
Published: May 2022

AbstractOsteoblast differentiation is critically reduced in various bone-related pathogenesis, including arthritis and osteoporosis. For future development of effective regenerative therapeutics, herein, we reveal the involved molecular mechanisms of a phytoestrogen, ferutinin-induced initiation of osteoblast differentiation from dental pulp-derived stem cell (DPSC). We demonstrate the significantly increased expression level of a transcription factor, Kruppel-like factor 2 (KLF2) along with autophagy-related molecules in DPSCs after induction with ferutinin. The loss-of-function and the gain-of-function approaches of KLF2 confirmed that the ferutinin-induced KLF2 modulated autophagic and OB differentiation-related molecules. Further, knockdown of the autophagic molecule (ATG7 or BECN1) from DPSC resulted not only in a decreased level of KLF2 but also in the reduced levels of OB differentiation-related molecules. Moreover, mitochondrial membrane potential-related molecules were increased and induction of mitophagy was observed in DPSCs after the addition of ferutinin. The reduction of mitochondrial as well as total ROS generations; and induction of intracellular Ca2+ production were also observed in ferutinin-treated DPSCs. To test the mitochondrial respiration in DPSCs, we found that the cells treated with ferutinin showed a reduced extracellular acidification rate (ECAR) than that of their vehicle-treated counterparts. Furthermore, mechanistically, chromatin immunoprecipitation (ChIP) analysis revealed that the addition of ferutinin in DPSCs not only induced the level of KLF2, but also induced the transcriptionally active epigenetic marks (H3K27Ac and H3K4me3) on the promoter region of the autophagic molecule ATG7. These results provide strong evidence that ferutinin stimulates OB differentiation via induction of KLF2-mediated autophagy/mitophagy.
Multimodal CEA-targeted fluorescence and radioguided cytoreductive surgery for peritoneal metastases of colorectal origin
Authors: de Gooyer Jan Marie , Elekonawo Fortuné M. K. , Bremers Andreas J. A. , Boerman Otto C. , Aarntzen Erik H. J. G. , de Reuver Philip R. , Nagtegaal Iris. D. , Rijpkema Mark , de Wilt Johannes H. W. 
Published: May 2022

AbstractIn patients with colorectal peritoneal metastases scheduled for cytoreductive surgery, accurate preoperative estimation of tumor burden and subsequent intraoperative detection of all tumor deposits remains challenging. In this study (ClinicalTrials.gov NCT03699332) we describe the results of a phase I clinical trial evaluating [111In]In-DOTA-labetuzumab-IRDye800CW, a dual-labeled anti-carcinoembryonic antigen (anti-CEA) antibody conjugate that enables both preoperative imaging and intraoperative radioguidance and fluorescence imaging. Primary study outcomes are safety and feasibility of this multimodal imaging approach. Secondary outcomes are determination of the optimal dose, correlation between tracer uptake and histopathology and effects on clinical strategy. Administration of [111In]In-DOTA-labetuzumab-IRDye800CW is well-tolerated and enables sensitive pre- and intraoperative imaging in patients who receive 10 or 50 mg of the tracer. Preoperative imaging revealed previously undetected lymph node metastases in one patient, and intraoperative fluorescence imaging revealed four previously undetected metastases in two patients. Alteration of clinical strategy based on multimodal imaging occurred in three patients. Thus, multimodal image-guided surgery after administration of this dual-labeled tracer is a promising approach that may aid in decision making before and during cytoreductive surgical procedures.
Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans
Authors: Maglioni Silvia , Schiavi Alfonso , Melcher Marlen , Brinkmann Vanessa , Luo Zhongrui , Laromaine Anna , Raimundo Nuno , Meyer Joel N. , Distelmaier Felix , Ventura Natascia 
Published: May 2022

AbstractComplex-I-deficiency represents the most frequent pathogenetic cause of human mitochondriopathies. Therapeutic options for these neurodevelopmental life-threating disorders do not exist, partly due to the scarcity of appropriate model systems to study them.Caenorhabditis elegansis a genetically tractable model organism widely used to investigate neuronal pathologies. Here, we generateC. elegansmodels for mitochondriopathies and show that depletion of complex I subunits recapitulates biochemical, cellular and neurodevelopmental aspects of the human diseases. We exploit two models,nuo-5/NDUFS1- andlpd-5/NDUFS4-depleted animals, for a suppressor screening that identifies lutein for its ability to rescue animals’ neurodevelopmental deficits. We uncover overexpression of synaptic neuroligin as an evolutionarily conserved consequence of mitochondrial dysfunction, which we find to mediate an early cholinergic defect inC. elegans. We show lutein exerts its beneficial effects by restoring neuroligin expression independently from its antioxidant activity, thus pointing to a possible novel pathogenetic target for the human disease.
Next-generation biomonitoring of the early-life chemical exposome in neonatal and infant development
Authors: Jamnik Thomas , Flasch Mira , Braun Dominik , Fareed Yasmin , Wasinger Daniel , Seki David , Berry David , Berger Angelika , Wisgrill Lukas , Warth Benedikt 
Published: May 2022

AbstractExposure to synthetic and natural chemicals is a major environmental risk factor in the etiology of many chronic diseases. Investigating complex co-exposures is necessary for a holistic assessment in exposome-wide association studies. In this work, a sensitive liquid chromatography-tandem mass spectrometry approach was developed and validated. The assay enables the analysis of more than 80 highly-diverse xenobiotics in urine, serum/plasma, and breast milk; with detection limits generally in the pg-ng mL−1 range. In plasma of extremely-premature infants, 27 xenobiotics are identified; including contamination with plasticizers, perfluorinated alkylated substances and parabens. In breast milk samples collected longitudinally over the first 211 days post-partum, 29 analytes are detected, including pyrrolizidine- and tropane alkaloids which have not been identified in this matrix before. A preliminary estimation of daily toxicant intake via breast milk is conducted. In conclusion, we observe significant early-life co-exposure to multiple toxicants, and demonstrate the method’s applicability for large-scale exposomics-type cohort studies.
Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia
Authors: Bassal Mahmoud A. , Samaraweera Saumya E. , Lim Kelly , Benard Brooks A. , Bailey Sheree , Kaur Satinder , Leo Paul , Toubia John , Thompson-Peach Chloe , Nguyen Tran , Maung Kyaw Ze Ya , Casolari Debora A. , Iarossi Diana G. , Pagani Ilaria S. , Powell Jason , Pitson Stuart , Natera Siria , Roessner Ute , Lewis Ian D. , Brown Anna L. , Tenen Daniel G. , Robinson Nirmal , Ross David M. , Majeti Ravindra , Gonda Thomas J. , Thomas Daniel , D’Andrea Richard J. 
Published: May 2022

AbstractThe interaction of germline variation and somatic cancer driver mutations is under-investigated. Here we describe the genomic mitochondrial landscape in adult acute myeloid leukaemia (AML) and show that rare variants affecting the nuclear- and mitochondrially-encoded complex I genes show near-mutual exclusivity with somatic driver mutations affecting isocitrate dehydrogenase 1 (IDH1), but not IDH2 suggesting a unique epistatic relationship. Whereas AML cells with rare complex I variants or mutations in IDH1 or IDH2 all display attenuated mitochondrial respiration, heightened sensitivity to complex I inhibitors including the clinical-grade inhibitor, IACS-010759, is observed only for IDH1-mutant AML. Furthermore, IDH1 mutant blasts that are resistant to the IDH1-mutant inhibitor, ivosidenib, retain sensitivity to complex I inhibition. We propose that the IDH1 mutation limits the flexibility for citrate utilization in the presence of impaired complex I activity to a degree that is not apparent in IDH2 mutant cells, exposing a mutation-specific metabolic vulnerability. This reduced metabolic plasticity explains the epistatic relationship between the germline complex I variants and oncogenic IDH1 mutation underscoring the utility of genomic data in revealing metabolic vulnerabilities with implications for therapy.
Dissociable multi-scale patterns of development in personalized brain networks
Authors: Pines Adam R. , Larsen Bart , Cui Zaixu , Sydnor Valerie J. , Bertolero Maxwell A. , Adebimpe Azeez , Alexander-Bloch Aaron F. , Davatzikos Christos , Fair Damien A. , Gur Ruben C. , Gur Raquel E. , Li Hongming , Milham Michael P. , Moore Tyler M. , Murtha Kristin , Parkes Linden , Thompson-Schill Sharon L. , Shanmugan Sheila , Shinohara Russell T. , Weinstein Sarah M. , Bassett Danielle S. , Fan Yong , Satterthwaite Theodore D. 
Published: May 2022

AbstractThe brain is organized into networks at multiple resolutions, or scales, yet studies of functional network development typically focus on a single scale. Here, we derive personalized functional networks across 29 scales in a large sample of youths (n = 693, ages 8–23 years) to identify multi-scale patterns of network re-organization related to neurocognitive development. We found that developmental shifts in inter-network coupling reflect and strengthen a functional hierarchy of cortical organization. Furthermore, we observed that scale-dependent effects were present in lower-order, unimodal networks, but not higher-order, transmodal networks. Finally, we found that network maturation had clear behavioral relevance: the development of coupling in unimodal and transmodal networks are dissociably related to the emergence of executive function. These results suggest that the development of functional brain networks align with and refine a hierarchy linked to cognition.
Precisely translating computed tomography diagnosis accuracy into therapeutic intervention by a carbon-iodine conjugated polymer
Authors: Yin Mingming , Liu Xiaoming , Lei Ziqiao , Gao Yuting , Liu Jiacheng , Tian Sidan , Liang Zhiwen , Wang Ye , Meng Fanling , Luo Liang 
Published: May 2022

AbstractX-ray computed tomography (CT) has an important role in precision medicine. However, CT contrast agents with high efficiency and the ability to translate diagnostic accuracy into therapeutic intervention are scarce. Here, poly(diiododiacetylene) (PIDA), a conjugated polymer composed of only carbon and iodine atoms, is reported as an efficient CT contrast agent to bridge CT diagnostic imaging with therapeutic intervention. PIDA has a high iodine payload (>84 wt%), and the aggregation of nanofibrous PIDA can further amplify CT intensity and has improved geometrical and positional stability in vivo. Moreover, with a conjugated backbone, PIDA is in deep blue color, making it dually visible by both CT imaging and the naked eyes. The performance of PIDA in CT-guided preoperative planning and visualization-guided surgery is validated using orthotopic xenograft rat models. In addition, PIDA excels clinical fiducial markers of imaging-guided radiotherapy in efficiency and biocompatibility, and exhibits successful guidance of robotic radiotherapy on Beagles, demonstrating clinical potential to translate CT diagnosis accuracy into therapeutic intervention for precision medicine.