bluuebunny/crossref_metadata_2025_split huggingface dataset:
The forgotten role of absorption in music reward
Authors: Cardona Gemma , Ferreri Laura , Lorenzo‐Seva Urbano , Russo Frank A. , Rodriguez‐Fornells Antoni 
Published: May 2022

AbstractInterindividual differences in music‐related reward have been characterized as involving five main facets: musical seeking, emotion evocation, mood regulation, social reward, and sensory‐motor. An interesting concept related to how humans decode music as a rewarding experience is music transcendence or absorption (i.e., music‐driven states of complete immersion, including momentary loss of self‐consciousness or even time‐space disorientation). Here, we investigated the relation between previously characterized facets of music reward and individual differences in music absorption. A first sample of participants (N = 370) completed both the Barcelona Music Reward Questionnaire (BMRQ) and the Absorption in Music Scale (AIMS). Results showed that both constructs were highly interrelated (r = 0.78, p < 0.001), indicating that higher music reward sensitivity is associated with a greater tendency to music‐related absorption states. In addition, four items from the AIMS were identified as suitable to be added to an extended version of the BMRQ (eBMRQ). A second sample (N = 550) completed the eBMRQ for a validation study. Exploratory and confirmatory factor analyses on the whole sample (N = 920) showed the reliable psychometric properties of the eBMRQ and suggested that taking into account an absorption facet could contribute to a better characterization of individual differences in the sensitivity to experience music‐related reward and pleasure.
Efficacy of injectable platelet‐rich fibrin in the treatment of symptomatic oral lichen planus
Authors: Al‐Hallak Noor , Hamadah Omar , Mouhamad Manal , Kujan Omar 
Published: May 2022

AbstractObjectivesThe use of autologous platelet concentrates has shown growing evidence as a promising therapy. We conducted a split‐mouth study to evaluate the effectiveness of injectable platelet‐rich fibrin (PRF) compared with triamcinolone acetonide (TA) in the treatment of oral lichen planus (OLP).Materials and methodsThis split‐mouth randomized trial included 12 patients with symptomatic, bilateral OLP lesions. The participants were randomly allocated to receive a 1‐ml intralesional PRF injection on one side of the buccal mucosa and a 0.5‐ml TA injection on the counterpart side. The application was performed once a week for 4 weeks. The outcomes were measured using a visual analog scale score, REU score, and lesion areas.ResultsBoth injectable TA and PRF were effective in the management of oral lichen planus. After 4 weeks of treatment, there was an average reduction in the VAS score (68.5% i‐PRF, 91% TA) and an average reduction in the REU score (74% i‐PRF, 91% TA). There were no statistically significant differences between the two treatment methods (p > 0.05).ConclusionsIntralesional injection with TA showed more effectiveness than i‐PRF in the management of OPL lesions. Although, i‐PRF cannot be considered a first‐line treatment option, it showed promising alternative therapy choice with no side effects.
Citizen participation matters. Bureaucratic discretion matters more
Authors: Young Sarah L. , Tanner James 
Published: May 2022

AbstractNew Public Governance theory increases citizen participation and expands bureaucrats' roles in the work of government. Citizen participation creates new mechanisms for citizens to influence the policy process. Bureaucrats' expanded roles allow for broader bureaucratic discretion over policy implementation. When citizens' and bureaucrats' views on public management decisions collide, whose views prevail? Do citizen volunteers or bureaucrats have greater influence over public decisions? We answer this question by studying the U.S. Department of Energy's initiative to engage citizens in environmental clean‐up decisions. We assess 10 years of meeting records and administrative decisions using a three‐step, mixed‐method analysis to identify, weigh, and test the influence of citizen participation and bureaucratic discretion. The results indicate that while citizen participation matters, bureaucratic discretion has a more significant influence over administrative decision‐making. The findings expose holes in New Public Governance theory, which has implications for democracy and demands deeper thought into structuring citizen participation.
OsUGE3‐mediated cell wall polysaccharides accumulation improves biomass production, mechanical strength, and salt tolerance
Authors: Tang Yijun , Wang Meihan , Cao Liyu , Dang Zhengjun , Ruan Nan , Wang Ye , Huang Yingni , Wu Jiayi , Zhang Mingfei , Xu Zhengjin , Chen Wenfu , Li Fengcheng , Xu Quan 
Published: May 2022

AbstractCell walls constitute the majority of plant biomass and are essential for plant resistance to environmental stresses. It is promising to improve both plant biomass production and stress resistance simultaneously by genetic modification of cell walls. Here, we report the functions of a UDP‐galactose/glucose epimerase 3 (OsUGE3) in rice growth and salt tolerance by characterizing its overexpressing plants (OsUGE3‐OX) and loss‐of‐function mutants (uge3). The OsUGE3‐OX plants showed improvements in biomass production and mechanical strength, whereas uge3 mutants displayed growth defects. The OsUGE3 exhibits UDP‐galactose/glucose epimerase activity that provides substrates for polysaccharides polymerization, consistent with the increased biosynthesis of cellulose and hemicelluloses and strengthened walls in OsUGE3‐OX plants. Notably, the OsUGE3 is ubiquitously expressed and induced by salt treatment. The uge3 mutants were hypersensitive to salt and osmotic stresses, whereas the OsUGE3‐OX plants showed improved tolerance to salt and osmotic stresses. Moreover, OsUGE3 overexpression improves the homeostasis of Na+ and K+ and induces a higher accumulation of hemicelluloses and soluble sugars during salt stress. Our results suggest that OsUGE3 improves biomass production, mechanical strength, and salt stress tolerance by reinforcement of cell walls with polysaccharides and it could be targeted for genetic modification to improve rice growth under salt stress.
Ratings of the physical attractiveness of an interaction partner after a getting‐acquainted interaction
Authors: Sprecher Susan , Hatfield Elaine 
Published: May 2022

AbstractThis study examined college students' judgments of the physical attractiveness of an interaction partner after a getting‐acquainted interaction, including in comparison with other benchmarks (e.g., an experimenter rating, a self‐rating). With data combined from several past laboratory studies, we found that participants (particularly women who were interacting with another woman) overall rated their interaction partner after a brief interaction to be more attractive than three benchmarks: (1) how the partners were judged by more neutral experimenters who had less interaction with them; (2) how the partners rated themselves; and (3) the participants' own self‐ratings of physical attractiveness. Evidence was found for a prediction derived from interaction appearance theory – ratings of the quality (enjoyment) of the interaction were positively associated with ratings of the partner's physical attractiveness. We also explored whether participants' ratings of the physical attractiveness of their interaction partner were affected by factors about the participant (own physical attractiveness, relationship status) and about the context of their communication (modality, type of get‐acquainted task). Despite prior work suggesting that physical attractiveness ratings of others are malleable depending on a host of other factors, personal and contextual variables considered in this study were generally not associated with how the participants rated the physical attractiveness of their interaction partner.
Functional Peaks-Over-Threshold Analysis
Authors: de Fondeville Raphaël , Davison Anthony C. 
Published: May 2022

AbstractPeaks-over-threshold analysis using the generalised Pareto distribution is widely applied in modelling tails of univariate random variables, but much information may be lost when complex extreme events are studied using univariate results. In this paper, we extend peaks-over-threshold analysis to extremes of functional data. Threshold exceedances defined using a functional r are modelled by the generalised r-Pareto process, a functional generalisation of the generalised Pareto distribution that covers the three classical regimes for the decay of tail probabilities, and that is the only possible continuous limit for r-exceedances of a properly rescaled process. We give construction rules, simulation algorithms and inference procedures for generalised r-Pareto processes, discuss model validation and apply the new methodology to extreme European windstorms and heavy spatial rainfall.
The impact of employment protection onFDIat different stages of economic development
Authors: Ardiyono Sulistiyo K. , Patunru Arianto A. 
Published: May 2022

AbstractThere has been much debate on how to design employment protection regulations that balance the need to attract foreign direct investment (FDI) on the one hand and to protect workers' rights on the other hand. This study explores this ‘dilemma’, using a multi‐country dataset from 2003 to 2015 and treating hiring and firing regulation (HFR) and the other explanatory variables as endogenous. The findings indicate that flexible HFR is essential for FDI promotion in the early stages of economic development of a country, but the impact of labour market flexibility on FDI gradually decreases and eventually turns statistically insignificant with economic advancement. In other words, a flexible HFRs are more important for developing countries, but such flexibility does not have to be sustained in a ‘race to the bottom’ manner: once a country reaches higher income levels, it has more room to focus on labour standards to protect workers without compromising on the attractiveness of the country for FDI.
An observational approach to mudstone sequence stratigraphy: The Monterey Formation of California
Authors: Schwalbach Jon R. , Bohacs Kevin M. 
Published: May 2022

ABSTRACT
Sequence stratigraphy has proven to be an invaluable tool for the analysis of coarse-clastic depositional systems and the integration of observations across scales from reflection seismic to scanning electron microscope. Applications to mudstone-dominated depositional sequences have been more limited, despite the fact that mudstones make up more than 60% of the global sedimentary volume and generally provide the most complete record of sedimentation in a basin.
During the late 1970s and through the 1980s, Bob Garrison and his students at the University of California–Santa Cruz conducted numerous studies that revealed the basic sedimentary and stratigraphic framework of the Monterey Formation in California, advancing our understanding of the sedimentary processes at work in these deep-margin basins. We expanded on that framework using direct observations from outcrops and cores that have been integrated with other subsurface data, as well as a wide variety of information derived from paleontologic, chronostratigraphic, geochemical, and compositional analyses to illustrate a sequence-stratigraphic approach to interpreting fine-grained rocks and their associated depositional systems in these settings. These were some of the earliest investigations of mudstone sequence stratigraphy focused on slope and basinal environments.
In this study, observations from outcrops in the Pismo Basin, California, provided the basis for developing a detailed sequence-stratigraphic framework for the Monterey Formation, expanding on the broad-scale characterization of Garrison and his colleagues. These outcrops represent deposition during different phases of basin evolution and in different borderland-type basin settings (slope and basin depocenters). Comparison of coeval strata from different depositional settings and locations documented variation at both the sequence and parasequence scale. Variation of parasequence character, in particular, provided a valuable tool for enhanced understanding of deposition and diagenesis in these margin basins. Extrapolation to the subsurface using gamma-ray logs greatly enhanced basinwide application compared to limited, partial-stratigraphic-section outcrops, and it facilitated the lateral characterization of mudstone depositional sequences. These elements served as the building blocks for improved models of deposition in margin-basin settings.
IMPDB: Indian Medicinal Phytochemical Database Curated for Drug Designing
Authors: Sinha S. , Hazarika A. , Johari S. , Neog B. , Rajkhowa S. , Biswas A. 
Published: May 2022

Background: A paradigm shift towards a multifaceted natural product drug discovery approach has been observed globally. Today, many modern drugs have originated from ethnopharmacology and traditional medicine. The traditionally used medicinal plants are a rich source of biologically active phytochemicals. A paradigm shift has been observed in pharmaceutical industries towards the use of those phytochemicals for the development of drugs over synthetic compounds for minimization of side effects. Methodology: The data have been generated from the printed “Database on Medicinal Plants Used in Ayurveda” published by the Central Council for Research in Ayurvedic Sciences, Government of India. The curation of the phytochemicals and calculation of their physicochemical and drug-like properties has been done using Discovery Studio v 4.5, and the database IMPDB is designed by adhering to the principles of database design and developed using PHP as front-end and MySQL as back-end. The data in IMPDB were analyzed further and comparative analysis of physicochemical properties of IMPDB phytochemicals with other small molecule databases, followed by druggability and novelty analysis of phytochemicals of the database were conducted with wQED score and molecular fingerprinting methods. In addition to that, ADMET properties of IMPDB phytochemical were compared with FDA-approved drugs. Results: Druggability analysis of IMPDB phytochemical shows a substantial number of them are druggable. An extensive review of the existing database was conducted and the quality of data of existing databases was matched with IMPDB data, and IMPDB data was found at par with the standard databases in the same domain, in certain parameters the quality of data of IMPDB was found better. In addition to that, novelty analysis of IMPDB data in comparison to 2068 FDA-approved drugs reveals that 99.96–99.99% of the phytochemical of IMPDB is novel and to some extent better in terms of ADMET properties. The database is available from https://impdb.org.in/ . Conclusion: IMPDB can be a useful database for the drug development industry and a need for the future pharmaceutical industry.
Unusual sauropod slipping tracks preserved on a biostabilized tidal flat from the Lower Cretaceous of northern Patagonia, Argentina
Authors: Heredia Arturo M. , Pazos Pablo J. , Fernández Diana E. 
Published: May 2022

Abstract
Several elongated and other crescent-shaped impressions interpreted as dinosaur tracks and preserved on Lower Cretaceous tidal flat deposits from the Agrio Formation (northern Patagonia, Argentina) are studied in detail. These tracks were documented on a palaeosurface showing palaeotopographic differences over a short distance, related to the lateral migration of a tidal channel. A genetic order between biostabilization and bioturbation of the palaeosurface is recognized. Ripples generated within the channel during the flood tide were first biostabilized; there, horseshoe crab trace fossils were produced. Then, the area bearing the tracks studied here was subaerially exposed, with the biostabilized substrate generating a slippery surface. Scanning electron microscope analysis of the rims indicates that the microbial mat was disturbed by the trampling. Finally, microbial mats recovered, and some tracks preserved wrinkle marks inside the tracks. Taking into account the substrate properties and track features analysed (morphology, size, depth and orientation), it is concluded that the tracks were produced by dinosaurs, probably small sauropods, trampling on a slippery surface and moving parallel to the channel margin. This study is an unusual case of slipping tetrapod tracks preserved on a biostabilized tidal flat developed in a mixed carbonate–siliciclastic environment.
Corneal Endothelial Characteristics in Normal Chinese Han Children and Youngsters: A Study from the Specular Microscopy Descriptions
Authors: Xie Lilian , Fang Huilong , Xie Yuyu , Wang Haiyan , Liu Ru , Li Zhiyuan , Zhu Jundong 
Published: May 2022

Objective. To observe the morphological changes of corneal endothelial cells in healthy Chinese children and youngsters and analyze the sensitive and specificity of the endothelial assessments. Methods. 14,670 Chinese healthy volunteers enrolled were examined by specular microscopy, and the endothelial descriptive indexes: the central corneal thickness (CCT), endothelial cell density (ECD), coefficient of variation in average cell size (CV), the percentage of regular hexagonal cells (hexagonality, HEX), cell size of minimal cell (

S

min

), cell size of maximal cell (

S

max

), average cell size (

S

avg

), and size of standard deviation of cell area (

S

sd

) as well as sex and age were analyzed. Results. The average age of this study is

17.36
±
7.58

(4–30) years. There is no sex predominance: 7,260 male (49.5%) and 7,410 female (50.5%). The mean CCT, ECD, CV, HEX,

S

min
/
max

, S

avg

, and

S

sd

are

529.94
±
31.53

(437–644) μm,

3,051.28
±
375.49

(2,031–4,074) cells/mm2,

28.34
±
4.36

(18–40) %,

61.21
±
10.29

(17–89) %, (

147.79
±
21.94

to

678.29
±
120.96

) μm2,

332.74
±
44.62

μm2, and

95.02
±
23.17

μm2, respectively. The CCTs keep consistency. The ECD decreased rate is 1.02%/year. The curve of ECD and hexagonality expresses the same linear tender. The CCT and endothelial evaluation indexes have no sex predominant (

p
>
0.05

); the quantitative indicators: CCT, ECD, and HEX are significant negative associated with age (

p
=
0.001

or

p
<
0.001

); the variability indexes: the CV,

S

min

,

S

max

,

S

avg

, and

S

sd

are positive correlation (

p
<
0.001

). The coefficients of CCT, HE, and

S

min

are -0.35, -0.59, and 1.17, respectively. Conclusions. The ECD decrease rate is 1.02%/year of the normal Chinese Han childhood to the earlier adulthood. The ages 4 to 12, 13 to 20, and 21 to 30 can be named as the childhood, puberty and adulthood from endothelial biologic identity. The HEX is the sensitivity marks for the polymorphisms while the S min is the specificity indicator CVs upon the Topcon Noncon Specular microscopy results.
Genetic Cross-Talk between Oral Squamous Cell Carcinoma and Type 2 Diabetes: The Potential Role of Immunity
Authors: Fan Yunjian , Zhang Jie , Shi Jiayu , Chen Lin , Long Jiazhen , Zhang Shuqi , Liu Shuguang 
Published: May 2022

Background. This bioinformatics study was aimed at evaluating type 2 diabetes (T2D) and oral squamous cell carcinoma (OSCC) with regard to related immune cells and prognosis. Methods. We downloaded the data on OSCC from TCGA and for T2D from GEO database. Differentially expressed genes were analyzed, i.e., for OSCC genes with

p

value
<
0.01

,

log
2

FC

>
0

; and for T2D, genes with

p

value
<
0.05

,

log
2

FC

>
0

. The intersected genes between OSCC and T2D were cross-talk genes. The expression values of immune-related genes in case samples in OSCC and T2D were assessed and underwent multivariate and univariate analysis (Cox-PH model). The intersection between the immune genes and cross-talk genes was taken and further analyzed by recursive feature elimination (RFE), survival analysis, and ROC analysis. Results. 1008 cross-talk genes were acquired, including 28 common upregulated, 440 common downregulated, and 540 differently regulated DEGs. We extracted the gene expression value of 782 immune-related genes, of which seven increased immune cells were obtained. From the results, plasmacytoid dendritic cells and effector memory CD8 T cells were highly negatively correlated in both OSCC and T2D. After estimating a low- and high-risk model for survival, we found that activated dendritic cell was significantly different between high and low groups (

p
=
0.0095

), followed by plasmacytoid dendritic cell. We integrated DE_Immune genes set 1 and DE_Immune genes set 2 and eight key immune-related cross-talk genes (C1QC, ABCD1, NOS2, PDIA4, IL1RN, ALOX15, CSE1L, and PSMC4) were evaluated. After ROC analysis, we obtained that ABCD1, C1QC, CSE1L, and PSMC4 had higher classification and prediction effects on OSCC and T2D. Conclusion. This study revealed a close relationship between T2D and OSCC. Thereby, plasmacytoid dendritic cell and activated dendritic cell-related genes were associated with the survival of T2D-related OSCC, while ABCD1, C1QC, CSE1L, and PSMC4 were the most important immune-related cross-talk genes.
Mutation Type and Intracranial Aneurysm Formation in Autosomal Dominant Polycystic Kidney Disease
Authors: Kataoka Hiroshi , Akagawa Hiroyuki , Ushio Yusuke , Sato Masayo , Manabe Shun , Makabe Shiho , Kawachi Keiko , Akihisa Taro , Iwasa Naomi , Yoshida Rie , Tsuchiya Ken , Nitta Kosaku , Mochizuki Toshio 
Published: May 2022

Background
Screening for intracranial aneurysms (IAs) in patients with risk factors of IA is recommended. However, genetic risk factors of IA in patients with autosomal dominant polycystic kidney disease (ADPKD) remain unclear, and genotype–phenotype relationships in IAs in patients with ADPKD have not been clarified. Therefore, we aimed to clarify the associations between germline mutations and IA formation in patients with ADPKD.

Methods
A total of 135 patients with ADPKD who were evaluated for ADPKD mutations were examined for IA formation in this single‐center observational study.

Results

The incidence of de novo IA formation was 1.3% per patient‐year. Age at IA diagnosis was younger in patients with frameshift (median, 36 years;
P
=0.003) and splicing mutations (median, 43 years;
P
=0.046) than in patients with substitutions (median, 63 years). Multivariable analyses showed that IA was associated with female sex (odds ratio [OR], 3.32 [95% CI, 1.10–10.01];
P
=0.03), a family history of IA or subarachnoid hemorrhage (OR, 3.05 [95% CI, 1.07–8.71];
P
=0.04), estimated glomerular filtration rate (OR, 0.69 [95% CI, 0.54–0.87];
P
=0.002), and splicing mutations (OR, 9.30 [95% CI, 1.71–50.44];
P
=0.01). Splicing mutations showed a significant association with IA formation even in subcohorts with minimal risk factors for IA, such as age <50 years (OR, 19.52 [95% CI, 3.22–118.51];
P
=0.001), nonhypertension (OR, 49.28 [95% CI, 3.60–673.98];
P
=0.004), and nonsmoking behavior (OR, 27.79 [95% CI, 3.49–221.21];
P
=0.002). Conversely, substitutions showed significant associations with IA formation in subcohorts such as age ≥50 years (OR, 8.66; 95% CI, 1.43–52.51;
P
=0.02) and chronic kidney disease stages 4 and 5 (OR, 10.70 [95% CI, 1.05–108.75];
P
=0.045).

Conclusions
Genetic analyses in patients with ADPKD could contribute to IA screening and could be useful for evaluating the prognosis, including complications. IA screening should be recommended for patients with ADPKD who have splicing and frameshift mutations and for older patients or patients with advanced ADPKD who have substitutions.