bluuebunny/crossref_metadata_2025_split huggingface dataset:
HIFZH AL-â€˜IRá¸Œ DALAM TRANSFORMASI SOSIAL MODERN (Upaya Menjadikan Hifzhu Al-â€˜Irá¸ Sebagai MaqÄshid Al-DharÅ«rÄ«y)
Authors: Husamuddin MZ, Lc., M.A.  
Published: August 2022

The old maqÄshid theory which still survives and is popular among ushuliyÅ«n, there are five known as al-dharÅ«riyyÄt al-khamsah. The discourse to add al-dharÅ«riyyÄt al-khamsah to aldharÅ«riyyÄt al-sittah or al-sab'ah and so on, has been rolled out by ushuliyÅ«n figures, although the addition received mixed responses. One of the additional discourses is to make hifzhu al â€˜irdh part of al-dharÅ«riyyÄt. Such discourse has been offered by TÄj al-din al-subki in the book jamÃ¢u al-jawÄmiâ€™, as well as At-ThÅ«fi and Al-qarÄfi, only Al-qarÄfi is not so strict. The modern figure who offered the idea back was Yusuf Al-Qaradhawi who later received a positive response from Muhammad Ahmad Al-QayatÄ« in his dissertation. Al-SyÄthibi makes hifzhu al-â€˜irdh included in the category of hifzhu al-nafs. Likewise AlGhazali and Ibn Al-Hajib did not make hifzhu al-â€˜irdh included in the category of al-dharÅ«rÄ«y. This attitude is supported by modern maqÄshid figures including Ibn â€˜Ä€syur, Ramadan Al-Buthi and Ahmad Al-Raisuni. In addition there is also a third opinion offered by Ibn Zaghibah â€˜izz Al-Din who made hifzhul al-'irdh part of dharuriyat but not in the kulliyah category but included in the juzâ€™iyyah category. The study was conducted using descriptive analysis methods, with data library research techniques (library research), the approach taken was a sociological approach. The results of the study note that: (1) the existence of times and technology that is so fast and 'radical', indirectly affect social and legal changes; (2) the existence of ikhtilÄf among ushuliyÅ«n and related modern figures to make hifzhu al-â€˜irdh as the category of al-dharÅ«riy or al-hÄjiy; (3) with the social transformation that is so fast, then the discourse makes hifzhu al-sebagaiirdh as categorical al-dharÅ«riy is a necessity.
Result of surgical treatment for pulmonary metastasis from hepatocellularcarcinoma
Authors: Binh Nguyen Hoang 
Published: August 2022

Objective: Evaluating result of surgical treatment, prognosis factors to survival time in pulmonary metastasis (PM) from Hepatocellular carcinoma (HCC) patients at Cho Ray hospital.Method: A retrospective review of surgical treatment of PM from HCC patients at Cho Ray hospital from 11/2015 – 5/2020.Results: Total 24 PM from HCC patients were surgical treatment. The mean tumor size is 2.7  1.1cm (range 1- 6 cm). The mean FDI (free disease interval) is 23.37  21.23 (2 – 108) month. Most of patients were thoracoscopic wedge resection of pulmonary metastasis. There was no mortality and major complication, 2 patients with seroma. Folow up, 7 patients died. The mean survival time 25.7  4.7 tháng (1- 46 tháng). The rate of 1 year, 2 years, 3 years overall survival is 86.5 %, 46.2% and 30.8 respectively.Conclusion: Surgical resection is a safe and effective treatment in selected patients with pulmonary metastases from HCC.The patients with previous resection of HCC have survival time longer than those with transdermal ablation. The patients with serumAFP level &gt; 100 ng after HCC resection need to be screening chest CT Scans for PM
The Comparative Effectiveness Of Pruning Versus Pruning Plus Injection Of Trunk and/or Limb for Therapy Of Dutch Elm Disease in American Elms
Authors: Gregory Garold F. , Allison James R. 
Published: August 2022

AbstractDuring the 1976 season, American elm street trees infected with Dutch elm disease (DED) in Elmhurst, Illinois, and Shaker Heights, Ohio, were given one of the following treatments: (1) pruning; (2) limb injection with Lignasan BLP and pruning; (3) trunk injection with Lignasan BLP and pruning; or (4) truck and limb injections and pruning. Trees with wilt symptoms greater than 30 percent when discovered were not treated but removed as soon as possible. By the end of the 1977 season, Treatment 4 seemed the most effective, followed by Treatment 3. The lower the percent of symptoms at time of treatment, the more successful were Treatments 1 and 2. The superiority of Treatments 3 and 4 was particularly evident when symptoms at time of treatment were 10 or 15 percent. As the distance between the last visible staining by DED and the pruning cut increased, so did the percentage of therapeutic success. Limb and trunk injection with Lignasan BLP followed by pruning is another tool to be used in the battle against DED, and is most effective if used before the disease symptoms are widespread.
Ecological Footprint Affecting the Pro-environmental Behavior of Undergraduates of Rajabhat Mahasarakham University
Authors: Kaewhao Sapphasit 
Published: August 2022

The research objectives were to study Ecological Footprint for Shelter, Ecological Footprint for Food, Ecological Footprint for Transportation, Ecological Footprint for Cloth, Ecological Footprint for Medicine, and Ecological Footprint for Housing and Pro-environmental Behavior levels and to study the independent variables comprise of Ecological Footprint for Shelter, Ecological Footprint for Food, Ecological Footprint for Transportation, Ecological Footprint for Cloth, Ecological Footprint for Medicine and Ecological Footprint for Housing affecting dependent variable of Pro-environmental Behavior of undergraduates. This survey used a questionnaire to gather 400 undergraduates and 10,757 undergraduates of Rajabhat Mahasarakham University in the first semester of the academic year of 2021. The Multi-Stage sampling technique was employed to collect the sample. Multiple Regression Analysis was used to determine the relationship between independent and dependent variables.
The results illustrated that in a holistic view of Ecological Footprint for Shelter, Ecological Footprint for Food, Ecological Footprint for Transportation, Ecological Footprint for Cloth, Ecological Footprint for Medicine, and Ecological Footprint for Housing and Pro-environmental Behavior were most levels. Moreover, independent variables of Ecological Footprint for Shelter, Ecological Footprint for Food, Ecological Footprint for Transportation, Ecological Footprint for Cloth, Ecological Footprint for Medicine, and Ecological Footprint for Housing can predict the variation of the dependent variable of Pro-environmental behavior with 65.90 percent of power prediction (Adjusted R2 = 0.659). Ecological Footprint for Food was the highest effect with 0.248.
The Model of Health Promotion through Health Literacy Approach for the Elderly in Bangkok, Thailand
Authors: Durongrittichai Vanida , Buajalearn Hataichanok , Maleewong Kandavasee 
Published: August 2022

Elderly care focuses on slowing down deterioration and maintaining health later in life. This can be done through health promotion undertaken by systematic participation of the involvements aimed at helping the elderly attain health literacy, thereby enhancing their long-term self-reliance. The research was to 1) study the principle, objective, system, and mechanisms facilitating elderly club administration, 2) develop the models of health promotion through health literacy approach for the elderly, and 3) propose the policy suggestions for employing the developed model in the relevant areas. A mixed-method was used to study 634 Thai elderly. the 65 informants composed of the elderly committee and directors from six zones in Bangkok. The main results were the activities that contributed to the elderly’s health promotion in order of importance as “Walk, Eat, Sleep, Brain,” The process of the health literacy was sequenced by recognizing, trying to continually practice until good for health and tell good things to others. Factors facilitating the elderly club administration in four aspects composing of 1) committee, 2) budget, 3) materials, and 4) elderly members. The synthesized model was called Smart by LeIST @ BKK (Leadership: L, Information: I, Stakeholder: S, and Team: T). The major policy suggestions for employing the developed model in the relevant areas are the elderly clubs. Corresponded agencies should correctly analyze the elderly’s needs to cover “Walk, Eat, Sleep, Brain” and use them to organize activities or projects in the health literacy approach. The research suggests that the officers should apply this model by considering principles, objectives, systems, and mechanisms according to the context. The longitudinal study and qualitative research should be further examined to employ and adjust this model deeply.
AÇÃO COMBINADA DA L-GLUTAMINA E INSULINOTERAPIA MELHORA A MORFOMETRIA DOS ÁCINOS DA PARÓTIDA DE RATOS DIABÉTICOS
Authors: Alves Angela Maria Pereira , Defani Marli Aparecida , Godoi Vilma Aparecida Ferreira de , Borges Stephanie Carvalho , Alves Éder Paulo Belato 
Published: August 2022

Objetivo: Objetivou-se neste estudo, analisar se a ação combinada da L-glutamina e insulinoterapia melhora os parâmetros morfoquantitativos dos ácinos da parótida de ratos diabéticos. Métodos: Vinte e cinco ratos foram distribuídos em cinco grupos: Normoglicêmico (CSS); diabético (DSS); diabético suplementado com L-GLN (D-GLN-S); diabético e com injeção subcutânea de insulina Tresiba® (D-S-TRE) e diabético suplementado com L-GLN e com injeção subcutânea de insulina Tresiba® (D-GLN-TRE). Durante 30 dias, houve suplementação diária com solução salina e/ou L-glutamina (400 mg/kg por gavagem), e injeção subcutânea de solução salina e/ou Insulina Tresiba® (5 U/kg). Resultados: Não houve diferença significativa na densidade acinar dos grupos diabéticos em relação ao grupo controle CSS. Porém, o grupo tratado com apenas com insulina (D-S-TRE) e insulina mais a L-GLN (D-GLN-TRE) mostraram menor densidade acinar quando comprados com o grupo diabético DSS. Todos os grupos diabéticos apresentaram menor área acinar média em relação ao grupo controle CSS. Entre os grupos diabéticos, a área acinar média do grupo D-GLN-TRE foi maior comparada aos grupos DSS, D-GLN-S e D-S-TRE. Conclusão: Estes dados apontam para o efeito protetor da L-glutamina combinada com a insulina ao prevenir a densidade e atrofia acinar da glândula parótida de ratos diabéticos.
CBX3 promotes ovarian cancer progression by regulating p53/p21-mediated glucose metabolism via inhibiting NCOR2
Authors: Chen Hua , Han Cailing , Liu Dan , Wang Fang , Ha Chunfang 
Published: August 2022

IntroductionChromobox protein homolog 3 (CBX3) has been reported to regulate a variety of cellular biological functions and play an oncogenic role in various tumor. Nevertheless, the role of CBX3 remains vague in ovarian cancer. This research aimed to assess the role and potential regulatory mechanism of CBX3 in ovarian cancer.Material and methodsThe CBX3 expression was determined by qRT-PCR and western blotting in ovarian cancer tissues and cell lines. Cell proliferation, cycle and apoptosis were detected by using CCK-8 assay and flow cytometry. Transwell and wound healing assay were used to determine cell invasion and migration. Furthermore, the modulation of CBX3 on NCOR2 expression and p53/p21-mediated glycolysis was confirmed.ResultsThe expression of CBX3 was significant elevated in ovarian cancer tissues and cell lines. CBX3 knockdown inhibited cell proliferation, invasion and migration, while promoted G1/S phase blockade and cell apoptosis. Mechanism analysis verified that CBX3 downregulation increased NCOR2 expression and blocked subsequent p53/p21-mediated glucose metabolism. NCOR2 silencing and p53/p21 inhibitor treatment reversed the inhibitory effects of CBX3 knockdown on ovarian cancer cellular function.ConclusionsWe revealed that CBX3 promoted ovarian cancer progression by promoting p53/p21-mediated glucose metabolism via inhibiting NCOR2. These results provide a theoretical basis for the diagnosis and treatment of ovarian cancer.
A worsened prognosis for patients after a stroke with newly diagnosed atrial fibrillation compared to having a preexisting arrhythmia.
Authors: Gorczyca-Głowacka Iwona , Tracz Justyna , Wożakowska-Kapłon Beata , Kołodziejska Ewa , Rosołowska Anita 
Published: August 2022

IntroductionAtrial fibrillation (AF) is a major cause of the ischemic stroke. Patients with undiagnosed AF lack the stroke prevention provided by oral anticoagulants. The aim of this study was to compare the in-hospital mortality rate between ischemic stroke patients diagnosed with AF de novo against ischemic stroke patients diagnosed with AF prior to hospitalization for stroke.Material and methodsWe identified patients admitted to the Neurology Center during the years 2013-2014 with acute ischemic stroke and AF. We analyzed in-hospital outcomes in patients with newly diagnosed AF and those with known AF. The study endpoint was death during hospitalization.ResultsThe study included 2,000 patients with acute ischemic stroke out of which 579 patients (29%) were diagnosed with AF. AF was newly diagnosed in 123 patients (21.2%) (new-AF group), while 456 patients (78.8%) had a history of AF (previous-AF group). Mean National Institutes of Health Stroke Scale (NIHSS) score at admission was 7.2 points in the new-AF group and 3.7 in previous-AF group (P<0.001). In-hospital death was more common in new-AF group (13 patients, 10.6%) than in previous-AF group (16 patients, 3.5%) (P=0.003). In multivariate analysis, the NIHSS score at admission in new-AF group was associated with higher mortality, while in previous-AF group, the NIHSS score at admission and multiple ischemic foci were risk factors of in-hospital mortality.ConclusionsNewly diagnosed AF in ischemic stroke patients significantly worsens prognosis compared to patients previously diagnosed with AF. Early detection of latent AF and subsequent use of anticoagulation is important in preventing severe stroke.
Outcomes of SARS-CoV-2 infection in patients under treatment with pharmacological immunosuppression. A Swiss cohort study.
Authors: Galante Antonio , Terziroli Beretta-Piccoli Benedetta , Pagnamenta Alberto , Ruinelli Lorenzo , Leo Massimo , De Gottardi Andrea 
Published: August 2022

IntroductionThe impact of pharmacological immunosuppression (IS) on COVID-19 outcomes is unclear. This study aimed at investigating the outcomes of hospitalised patients undergoing IS and focussed on length of hospital stay, admission to intensive care unit (ICU) and mortality.Material and methodsPatients admitted to public hospitals in Southern Switzerland with SARS-CoV-2 infection (n = 442) were prospectively included, and their data were collected and analysed. Immunosuppressed patients were compared to patients from the same cohort but without any IS.ResultsThirty-five patients (7.9%, 65.7% male, median age 70.6 years) were treated with IS at the time of hospital admission. Compared with patients without IS, immunosuppressed patients showed higher mortality (n = 16 / 35, 45.7% vs n = 95 / 407, 23.3% p = 0.003) and longer hospital stay (median = 15.5 days vs median = 11, p = 0.0144). Moreover, in the univariate and multivariable logistic regression analysis, IS was independently associated with mortality (OR = 2.76 (95%-CI: 1.37-5.59) and 2.66 -95%-CI: 1.19-5.94 -) and in the linear univariate and multivariable regression analysis with the length of stay (p = 0.005 and p = 0.007). Furthermore, patients under IS were more often admitted to the ICU, although the association was not significant (p = 0.069).ConclusionsPatients under IS were at a significantly higher risk of severe and prolonged COVID-19 disease, with higher mortality and more extended hospital stay than patients without IS.
A IMPORTÂNCIA DOS MÉTODOS DE EDIÇÃO GÊNICA NA DIMINUIÇÃO DOS CASOS DE CÂNCER DECORRENTES DA MUTAÇÃO DO GENE TP53: UMA REVISÃO
Authors: Martins Amanda Pezzini 
Published: August 2022

Introdução: Alternativas diversas vêm sendo testadas, como método de adição gênica na busca da substituição de genes TP53 mutantes de potencialidade cancerosa por similaridades que não causem qualquer efeito genotóxico no indivíduo. Tais genes se localizam no cromossomo 17, e tem sido associados à diferentes tipos de neoplasias devido ao grande número de variações apresentadas, principalmente entre os éxons 5 e 8. Objetivos: Alternativas diversas vêm sendo testadas, como método de adição gênica na busca da substituição de genes TP53 mutantes de potencialidade cancerosa por similaridades que não causem qualquer efeito genotóxico no indivíduo. A CRISPR/Cas9 é um dos mecanismos de edição gênica mais utilizados, que consiste na clivagem do gene afetado e substituição por um gene normal guiada pelo mecanismo de reparo DSB (Clivagem da dupla cadeia). Materiais e Métodos:: Revisão biliográfica de pesquisas envolvendo métodos genéticos para redução da expressão tumoral através da análise de artigos e publicações em revistas científicas, recursos disponíveis no National Center for Biotechnology Information (NCBI), PUBMED e Mouse Models of Human Cancer Database (MMHCdb). Foram palavras chave para a pesquisa das publicações: p53; biologia de tumores em camundongos; CRISPR e o câncer; supressão de tumor p53, dentre outros. Resultados e Discussão: Um número significativo de publicações é encontrado na literatura envolvendo papel do gene p53 no funcionamento celular normal e neoplásico, envolvendo praticamente todos os tipos de células. Outros recursos têm sido explorados em busca de uma alternativa clínica para a supressão tumoral e o controle de crescimento celular. Uma dessas possibilidades envolve o método de edição gênica CRISPR Cas9, tendo como principal foco o silenciamento de oncogenes, avaliando a supressão tumoral in vitro e in vivo. Conclusão: Os avanços científicos têm auxiliado no combate à cânceres, seja com o diagnóstico precoce, descoberta de novas drogas ou imunoterapia. Muitas técnicas tem sido aplicadas nas pesquisas e o cenário é otimista, sendo necessário mais estudos e recursos para que no futuro haja a possibilidade da redução drástica das mais de 9.6 milhões de mortes em todo o mundo.
MELHORAMENTO E EXPLORAÇÃO DE PLANTAS DIÓICAS
Authors: Silva Francismary Barros da , OLIVEIRA CARLOS ROBERTO SILVA DE , FILHO EZILDO FRANCISCO FELINTO , OLIVEIRA MATHEUS LIMA , SANTOS VIVIANE NUNES DOS 
Published: August 2022

Introdução: As plantas dioicas são caracterizadas pelo dimorfismo sexual tanto nas características sexuais (órgãos reprodutivos) flores estaminadas, pistiladas, como nas suas características sexuais secundárias, como diferenças entre tamanho e recursos atrativos geralmente associadas ao custo/sucesso de reprodução. Objetivo: Esta revisão bibliográfica acerca da temática melhoramento e exploração de plantas dioicas. Material e métodos: A revisão foi elaborada por meio da consulta em trabalhos nas plataformas indexadoras de artigos e outros trabalhos científicos Google Acadêmico, Portal de Periódicos da Capes e SciElO indexados com alto fator de impacto. Resultados: O melhoramento genético das plantas é beneficiado pelo cruzamento, favorecendo a manutenção da alta heterozigosidade, todavia como a base genética da dioicia apesar dos avanços ainda não é totalmente clara. A exploração dos avanços teóricos aplicados no melhoramento genético das plantas dioicas vem contribuindo para resolução de problemas práticos no desenvolvimento de novas cultivares em culturas agrícolas dioicas exemplo espinafre, aspargos, lúpulo, cannabis, kiwis, pistache tamareiras, mamão e figo. Além de existir um significativo de número de espécies silvestres com potencial farmacológico e florestal. Portanto a compreensão das bases genéticas das plantas dioicas contribui para exploração e o desenvolvimento de programas de melhoramento genético de plantas dioicas impulsionadas pelo maior entendimento dos mecanismos envolvidos no surgimento e manutenção da dioica em plantas nos últimos anos, possibilitaram uma melhor compressão em termos teóricos/práticos dessas características inerentes a separação sexual das plantas. E fornecem uma fonte rica de novos genes para a exploração e manipulação da reprodução e adaptação ambiental nas plantas dioicas. Conclusão: É necessário maiores estudos dos genomas de plantas dioicas e aplicações no melhoramento genético principalmente para espécies em processo de domesticação afim definir quais os mecanismos bioquímicos, fisiológicos e moleculares e evolutivos estão envolvidos e sua aplicação no melhoramento ou domesticação das plantas.
ESTUDOS CITOGENÉTICOS EM RINELORICARIA PENTAMACULATA (LORICARIIDAE:LORICARIINAE): UMA REVISÃO SISTEMÁTICA
Authors: PORTO FERNANDA ERRERO , PORTO FERNANDA ERRERO , MARTINS-SANTOS ISABEL CRISTINA 
Published: August 2022

Introdução: As espécies de peixes do gênero Rineloricaria apresentam 76 espécies válidas que sob o ponto de vista citogenético tem sido pouco investigada, contudo, apesar de escassos os estudos demostram que grande variabilidade cromossômica, com número diplóide variando de 2n=36 a 2n=70, além disso, polimorfismos cromossômicos numéricos e estruturais êem sido observados em algumas espécies do gênero, como na espécie Rineloricaria pentamaculata, com maior número de populações estudadas até o presente momento. Objetivo: Desta forma, o presente estudo tem por objetivo realizar uma revisão da literatura sobre os estudos citogenéticos conduzidos na espécie R. pentamaculata. Materiais e métodos: Foi realizada uma busca nas bases de dados PubMed, Google Acadêmico, Scientific Electronic Liberary Online (ScieELO), sendo encontrados 7 estudos (artigos, dissertações e teses em inglês e português) lidos na íntegra e compiladas informações referentes a local de coleta (nome do rio, ribeirão ou córrego), bacia hidrográfica e estado da federação, com relação aos dados citogenéticos foram reunidas informações sobre: número diplóide (2n), número fundamental (NF), fórmula cariotípica (FC), sistema de NOR e par portador da NOR (Ag-NOR e DNA 18S), quantidade e par portador de sítios de DNAr 5S e presença de cromossomos Bs. Resultados: Desta forma, as diferentes populações de R. pentamaculata apresentaram número diplóide variando de 2n=54 a 2n=58 cromossomos, além de diferenças nas fórmulas cariotípicas, número fundamental, sistema de NOR (simples e múltiplo) e presença de cromossomos B, sendo que a maioria dos estudos foram realizados em populações pertencentes a bacia do Alto Paraná. Contudo, a maioria das populações apresentaram características citogenéticas similares exibindo 2n=56 cromossomos distribuídos em 8m/sm+48st/a (número fundamental igual a 64) e sistema NOR simples revelado por hibridização fluorescente in situ (FISH) com sonda de rDNA 18S, nitrato de prata e banda C positiva, tais características foram consideradas conservadas para a espécie. Conclusão: Todos os estudos revisados sugerem que os rearranjos cromossômicos robertsonianos provavelmente contribuíram a evolução cariotípica da espécie, desta forma, discutimos aspectos relacionados a este e outros fatores associados a evolução do grupo.