bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equity, justice and the SDGs: lessons learnt from two decades of INEA scholarship
Authors: Gupta Joyeeta , Gupta Aarti , Vegelin Courtney 
Published: April 2022

AbstractEnvironmental justice issues have been incrementally but consistently covered within this journal in the last two decades. This article reviews theoretical and empirical approaches to justice in INEA scholarship in order to identify trends and draw lessons for the interpretation and implementation of the 2030 Agenda and for living within environmental limits. Our review traces how justice considerations were initially covered within new institutionalist scholarship on collective action and social practices, to conceptualizing justice as ‘access and allocation’, to newer notions of planetary justice. We link these trends to scholarship on diverse epistemologies and typologies of justice, including conservative, corrective, distributive and procedural justice, and examine their operationalization within the empirical domains of climate, water and sustainable development. In concluding, we draw out implications for the 2030 Sustainable Development Agenda. We argue that a just approach is essential to living within environmental limits, with greater synergies needed between collective action and social practice approaches. While justice can be unpacked for practical and political reasons into access and allocation, we find that (procedural) access considerations are more politically palatable in practice than a concern with allocation (distributive justice), which remains much more contested. As such, dominant approaches promote ‘conservative’ or thin market-based notions of justice. We conclude by noting that just allocation is a precondition to just access. A failure to prioritize and achieve more corrective and distributive forms of justice will, without doubt, contribute to exacerbating global ecological degradation.
Development and consensus testing of quality indicators for geriatric pharmacotherapy in primary care using a modified Delphi study
Authors: Sato Noriko , Fujita Kenji , Kushida Kazuki , Chen Timothy F. 
Published: April 2022

AbstractBackgroundPolypharmacy is associated with an increased risk of adverse drug events in older people. Although national guidance on geriatric pharmacotherapy exists in Japan, tools to routinely monitor the quality of care provided by community pharmacists are lacking.AimTo develop a set of quality indicators (QIs) to measure the quality of care provided by community pharmacists in improving geriatric pharmacotherapy in primary care in Japan, using a modified Delphi study.MethodThe development of QIs for the Japanese community pharmacy context followed a two–step process: national guidance review and consensus testing using a modified Delphi study. The latter involved two rounds of rating with a face–to–face meeting between the rounds. Ten experts in geriatric pharmacotherapy in primary care were recruited for the panel discussion. QIs were mapped to three key taxonomies and frameworks: the Anatomical Therapeutic Chemical (ATC) classification system, problems and causes of drug–related problems (DRPs) taxonomy and Donabedian’s framework.ResultsA total of 134 QIs for geriatric pharmacotherapy were developed. This QI set included 111 medicine specific indicators, covering medicines in 243 third–level ATC classifications. QIs were classified into the problem of treatment safety (80%) and causes of drug selection (38%) based on validated classification for DRPs. In Donabedian's framework, most QIs (82%) were process indicators. There were no structure indicators.ConclusionA set of 134 QIs for geriatric pharmacotherapy was rigorously developed. Measurement properties of these QIs will be evaluated for feasibility, applicability, room for improvement, sensitivity to change, predictive validity, acceptability and implementation issues in a subsequent study.
Uptake of silicon in barley under contrasting drought regimes
Authors: Wade Ruth N. , Donaldson Sarah M. , Karley Alison J. , Johnson Scott N. , Hartley Sue E. 
Published: April 2022

Abstract
Purpose
Silicon (Si) accumulation in plant tissues plays a vital role in alleviating biotic and abiotic stresses, including drought. Temperate regions are predicted to experience reductions in the quantity and frequency of rainfall events, potentially impacting plant Si uptake via the transpiration stream. Despite the importance for predicting plant responses to Si amendments, the effects of changes in rainfall patterns on Si uptake in cereals have not been characterised.

Methods
Five watering regimes were applied based on predicted precipitation scenarios, varying the quantity of water delivered (ambient, 40% or 60% reduction) and watering frequency (40% reduction in quantity, applied 50% or 25% of ambient frequency), and the effects on growth and leaf Si concentrations of a barley landrace and cultivar were determined.

Results
Reductions in the quantity of water reduced plant growth and yield, whereas reducing the watering frequency had little impact on growth, and in some cases partially ameliorated the negative effects of drought. Reductions in quantity of water lowered leaf Si concentrations in both the cultivar and landrace, although this effect was alleviated under the drought/deluge watering regime. The landrace had greater leaf Si concentration than the cultivar regardless of watering regime, and under ambient watering deposited Si in all cells between trichomes, whereas the cultivar exhibited gaps in Si deposition.

Conclusion
The impact of future reductions in rainfall on barley productivity will depend upon how the water is delivered, with drought/deluge events likely to have smaller effects on yield and on Si uptake than continuous drought.
University leagues alongside rankings
Authors: Banász Zsuzsanna , Kosztyán Zsolt T. , Csányi Vivien V. , Telcs András 
Published: April 2022

AbstractUniversity rankings can both orient and disorient potential students. In rankings, universities with very different characteristics are compared, which makes interpretation difficult. We propose the application of a clustering method, which creates groups of universities that are close to each other with respect to a subset of indicators, but the indicators also show homogeneity with respect to the universities in that group. We call such groups leagues. These leagues are defined by the data themselves and are not based on subjective criteria. We demonstrate our proposition using one member of the family of the two-way clustering method, namely, biclustering. The case we present is based on the Round University Ranking (RUR) 2020 dataset. The use of leagues could provide better guidance not only for potential applicants but also for university funding organizations and policy-makers. Our case study led to a somewhat surprising observation. In the top league (based on the RUR data and indicators), the three most important indicators measure reputation, not scientific or educational performance.
Immune Activation in Pregnant Rats Affects Brain Glucose Consumption, Anxiety-like Behaviour and Recognition Memory in their Male Offspring
Authors: Guerrin Cyprien G. J. , Shoji Alexandre , Doorduin Janine , de Vries Erik F. J. 
Published: April 2022

Abstract

Purpose
Prenatal infection during pregnancy is a risk factor for schizophrenia, as well as for other developmental psychiatric disorders, such as autism and bipolar disorder. Schizophrenia patients were reported to have altered brain metabolism and neuroinflammation. However, the link between prenatal infection, altered brain inflammation and metabolism, and schizophrenia remains unclear. In this project, we aimed to evaluate whether there are changes in brain glucose consumption and microglia activation in the offspring of pregnant rats exposed to maternal immune activation (MIA), and if so, whether these changes occur before or after the initiation of schizophrenia-like behaviour.

Procedures
Pregnant rats were treated with the viral mimic polyinosinic-polycytidylic acid (MIA group) or saline (control group) on gestational day 15. Static PET scans of the male offspring were acquired on postnatal day (PND) 21, 60, and 90, using [11C]-PK11195 and deoxy-2-[18F]fluoro-D-glucose ([18F]-FDG) as tracers to measure TSPO expression in activated microglia and brain glucose consumption, respectively. On PND60 and PND90, anxiety-like behaviour, recognition memory, and sensorimotor gating were measured using the open field test (OFT), novel object recognition test (NOR), and prepulse inhibition test (PPI).

Results
[18F]-FDG PET demonstrated that MIA offspring displayed higher brain glucose consumption in the whole brain after weaning (p = 0.017), and in the frontal cortex during late adolescence (p = 0.001) and adulthood (p = 0.037) than control rats. [11C]-PK11195 PET did not reveal any changes in TSPO expression in MIA offspring. Prenatal infection induced age-related behavioural alterations. Adolescent MIA offspring displayed a more anxious state in the OFT than controls (p = 0.042). Adult MIA offspring showed recognition memory deficits in the NOR (p = 0.003). Our study did not show any PPI deficits.

Conclusions
Our results suggest that prenatal immune activation changed neurodevelopment, resulting in increased brain glucose consumption, but not in microglia activation. The increased brain glucose consumption in the frontal cortex of MIA offspring remained until adulthood and was associated with increased anxiety-like behaviour during adolescence and recognition memory deficits in adulthood.
Targeted Therapy for Melanomas Without BRAF V600 Mutations
Authors: Menzer Christian , Hassel Jessica C. 
Published: April 2022

Opinion statementModern therapy of advanced melanoma offers effective targeted therapeutic options in the form of BRAF plus MEK inhibition for patients with BRAF V600 mutations. For patients lacking these mutations, checkpoint inhibition remains the only first-line choice for treatment of metastatic disease. However, approximately half of patients do not respond to immunotherapy, requiring effective options for a second-line treatment. Advances in genetic profiling have found other possible target molecules, especially a wide array of rare non-V600 BRAF mutations which may respond to available targeted therapy.More information on the characteristics of such mutants is needed to further assess the efficacy of targeted therapies in the metastatic and adjuvant setting of advanced melanoma. Thus, it may be helpful to classify known BRAF mutations by their kinase activation status and dependence on alternative signaling pathways. While BRAF V600 mutations appear to have an overall more prominent role of kinase activity for tumor growth, non-V600 BRAF mutations show great differences in kinase activation and, hence, response to BRAF plus MEK inhibition. When BRAF-mutated melanomas rely on additional signaling molecules such as RAS for tumor growth, greater benefit may be expected from MEK inhibition than BRAF inhibition. In other cases, mutations of c-kit or NRAS may serve as important pharmacological targets in advanced melanoma. However, since benefit from currently available targeted therapies for non-V600 mutants is usually inferior regarding response and long-term outcome, checkpoint inhibitors remain the standard recommended first-line therapy for these patients.Herein, we review the current clinical data for characteristics and response to targeted therapy of melanomas lacking a V600 BRAF mutation.
Conservative initial postoperative anticoagulation strategy after HeartMate 3 left ventricular assist device implantation
Authors: Damman Kevin , van den Broek Stan A. J. , Mecozzi Gianclaudio , Droogh Joep M. , Metz Ethel , Oude Lansink Annemieke , Krikken Jan A. , Erasmus Michiel E. , Kuijpers Michiel 
Published: April 2022

Abstract
Introduction
Although anticoagulation therapy is mandated after implantation of a left ventricular assist device (LVAD), postoperative bleedings and reoperations occur relatively frequently and are associated with worse outcomes. We evaluated the use of a conservative postoperative anticoagulation protocol in patients implanted with a HeartMate 3 (HM3) LVAD.

Methods
In a single-centre retrospective analysis of postoperative outcomes after HM3 LVAD implantation, a standard (old) anticoagulation protocol (i.e. early, full-dose anticoagulation with low-molecular weight heparin and overlapping vitamin K antagonist) was compared with a new conservative anticoagulation protocol (i.e. slow initiation of vitamin K antagonists without overlapping heparin). Main outcomes were changes in international normalised ratio (INR), lactate dehydrogenase (LDH), bleeding and/or tamponade events requiring reoperation, length of stay and adverse events.

Results
In total, 73 patients (48 in old vs 25 in new protocol group) were evaluated. Mean age was 56 years (standard deviation 13) and most patients (78%) were males. Changes in INR and LDH in the first 14 days were similar in both groups (p = 0.50 and p = 0.997 for interaction, respectively). Number of bleeding/tamponade events requiring reoperation was lower in the new than in the old protocol group (4% vs 33%, p = 0.005). Postoperative 30-day mortality was similar, and we observed no thromboembolic events. Median (25th–75th percentiles) total length of postoperative hospital stay (27 (25–41) vs 21 (19–27) days, p < 0.001) and length of intensive care unit stay (5 (2–9) vs 2 (2–5) days, p = 0.022) were significantly shorter in the new protocol group.

Conclusion
These retrospective data suggest that conservative slow initiation of anticoagulation therapy after HM3 LVAD implantation is associated with less bleeding/tamponade events requiring reoperation, a similar safety profile and a shorter duration of stay than the currently advised standard anticoagulation protocol.
Mitigating off-target distribution and enhancing cytotoxicity in breast cancer cells with alpha-ketoglutaric acid-modified Fe/Mg-CA nanoparticles
Authors: Haque Sheikh Tanzina , Karim Md. Emranul , Othman Iekhsan , Chowdhury Ezharul Hoque 
Published: April 2022

Abstract
Purpose
In this work, pH-sensitive alpha-ketoglutaric acid-modified Fe/Mg-carbonate apatite (α-KAM-Fe/Mg-CA) NPs were introduced and found to be capable of promoting the selective delivery of cancer-killing drug doxorubicin (DOX) in breast cancer cells, while simultaneously mitigating DOX toxicity on normal cells.

Methods
As part of the characterization and evaluation of α-KAM-Fe/Mg-CA NPs to target breast cancer cells, a series of assessments were performed, which included size measurements, morphological analysis, FTIR, cytotoxicity assessment, hemolysis, drug binding, cellular uptake, and pH-responsive drug release tests. Liquid chromatography-mass spectrometry was used to conduct the protein corona analysis of α-KAM-Fe/Mg-CA using 10% FBS (fetal bovine serum) and mice plasma. Furthermore, to investigate the distribution of DOX-loaded α-KAM-Fe/Mg-CA NPs in major tissues and the tumor, a biodistribution investigation was conducted in mammary tumor-induced Balb/c mouse models 24 h after the intravenous administration of DOX-loaded α-KAM-Fe/Mg-CA NPs.

Results
The in vitro pH-dependent release of DOX over time demonstrated that α-KAM-Fe/Mg-CA NPs were pH-responsive and degraded rapidly at acidic pH levels. When compared to free DOX, the DOX-loaded α-KAM-Fe/Mg-CA NPs demonstrated a potent antiproliferative effect on breast cancer cells. Confocal microscopy confirmed the effective internalization of DOX-loaded α-KAM-Fe/Mg-CA NPs in breast cancer cells. The protein corona analysis revealed an affinity for dysopsonins (serum albumin, apolipoproteins) and transport proteins that may assist in extending their blood circulation period. Furthermore, biodistribution data of DOX-loaded α-KAM-Fe/Mg-CA NPs in the mammary tumor-induced Balb/c mouse model indicated extended circulation in the bloodstream, reduced non-target distribution in major tissues, and increased drug accumulation in the tumor.

Conclusion
The results obtained suggest that α-KAM-Fe/Mg-CA NPs may emerge as a prospective candidate for delivering therapeutic cargos to treat malignant mammary tumors.
Numerical integration of neutrosophic valued function by Gaussian quadrature methods
Authors: Biswas Suvankar , Moi Sandip , Sarkar Smita Pal 
Published: April 2022

AbstractIn this article, different types of Gaussian quadrature methods have been presented to find the numerical integration of a neutrosophic valued function. A new definition of the distance between two neutrosophic number has been defined and it has been proved that the distance and the set of all neutrosophic number form a complete metric space. Also, the definition of neutrosophic continuity on a closed-bounded interval has been defined in the sense of $$(\alpha ,\beta ,\gamma )$$

(
α
,
β
,
γ
)

-cut. This is the first time, when the Gauss–Legendre integration, Gauss–Chebyshev integration and Gauss–Laguerre integration rule have been discussed in neutrosophic environment. In the first test example, the comparison between one-point, two-point and three-point Gauss–Legendre integration rules have been presented in terms of tables and figures. Also, in the second example, the comparison between one-point, two-point Gauss–Chebyshev and Gauss–Laguerre integration rules have been discussed.
Copyright and Digital Teaching Exceptions in the EU: Legislative Developments and Implementation Models of Art. 5 CDSM Directive
Authors: Priora Giulia , Jütte Bernd Justin , Mezei Péter 
Published: April 2022

AbstractArticle 5 of the 2019 EU Directive on Copyright in the Digital Single Market (CDSM) attempted to modernize the regime of copyright exceptions and limitations related to teaching activities. Its aim is to enhance the flexibility behind permitted uses to the benefit of educational institutions regarding their digital and cross-border teaching. The pressing need for such a legislative reform was confirmed by the outbreak of the COVID-19 pandemic, which dramatically moved teaching environments to online platforms. This paper dissects Art. 5 CDSM Directive unveiling three layers of analysis. First, the substance, logic, and promises of the new provision are introduced. Second, it identifies diverging national implementation models, developing a comparative study of the Hungarian, German, and Italian experiences. Third, drawing from the comparative study, the paper provides fundamental guidance in understanding whether Art. 5 CDSM Directive can be considered an evolution or, rather, a devolution of the copyright teaching exceptions in Europe. Focusing on the systematic concerns arising from the new provision, its embedded limits, and the strategic uses of the licensing carve-out, we conclude that the EU legislature has only partially achieved the goal of striking a more European, modern, and sustainable balance between copyright protection and the right to education in the digital environment.
Boundary and Eisenstein cohomology of $$G_2(\mathbb {Z})$$
Authors: Bajpai Jitendra , Guan Lifan 
Published: April 2022

AbstractIn this article, Eisenstein cohomology of the arithmetic group $$G_2(\mathbb {Z})$$

G
2

(
Z
)

with coefficients in any finite dimensional highest weight irreducible representation has been determined. This is accomplished by studying the cohomology of the boundary of the Borel–Serre compactification.
Fungal-derived compounds and mycogenic nanoparticles with antimycobacterial activity: a review
Authors: Tapfuma Kudzanai Ian , Nyambo Kudakwashe , Baatjies Lucinda , Keyster Marshal , Mekuto Lukhanyo , Smith Liezel , Allie Nasiema , Loxton Andre Gareth , Malgas-Enus Rehana , Mavumengwana Vuyo 
Published: April 2022

AbstractTuberculosis (TB) is a persistent lung infection caused by Mycobacterium tuberculosis. The disease is characterized by high mortality rates of over 1 million per year. Unfortunately, the potency and effectiveness of currently used anti-TB drugs is gradually decreasing due to the constant development of persistence and resistance by M. tuberculosis. The adverse side effects associated with current anti-TB drugs, along with anti-TB drug resistance, present an opportunity to bio-prospect novel potent anti-TB drugs from unique sources. Fundamentally, fungi are a rich source of bioactive secondary metabolites with valuable therapeutic potential. Enhancing the potency and effectiveness of fungal-based anti-TB drug leads by chemical synthesis and/or modification with nanomaterials, may result in the discovery of novel anti-TB drugs. In this review, the antimycobacterial activity of fungal-derived compounds and mycogenic nanoparticles are summarized. Numerous fungal-derived compounds as well as some mycogenic nanoparticles that exhibit strong antimycobacterial activity that is comparable to that of approved drugs, were found. If fully explored, fungi holds the promise to become key drivers in the generation of lead compounds in TB-drug discovery initiatives.
A new acoustoelastic model for velocity-hydrostatic-pressure in rocks based on general acoustoelastic theory for elastic solids
Authors: Tian Jiayong , Ma Hongfei , Wang Mi 
Published: April 2022

AbstractAcoustoelastic model based on classic acoustoelastic theory of solids fails to describe rock acoustoelasticity, where wave velocities in rocks has complex non-linear relations with the applied hydrostatic pressure. In order to extend acoustoelastic model into better prediction for rock acoustoelasticity, a new acoustoelastic model is presented based on general acoustoelasticity of elastic solids having complicated constitutive law of rocks, which combines third-order elastic constants of compact rocks with the exponential terms for the influence of pore/cracks in rocks. The data for P- and S-wave velocities of diabase and greywacke samples subjected to the pressure up to 400 MPa are taken as examples to validate the presented model. The results show that the presented model could not only predict rock acoustoelasticity but also be linked with frequently-used empirical model and meso-mechanical model. The intrinsic connection among mechanical parameters, acoustical parameters, and meso-mechanical parameters could be established clearly, which will benefit the determination of high-resolution constitutive law and the compliant porosity by the measured ultrasonic-wave velocities of rock samples.Article HighlightsGeneral acoustoelasticity of elastic solids having complicated constitutive law yields a new acoustoelastic model of rock acoustoelasticity.New model predicts better non-linear characteristics of rock acoustoelasticity.New model benefits for high-resolution evaluation of constitutive law and meso-mechanical parameters for rocks.