bluuebunny/crossref_metadata_2025_split huggingface dataset:
Romantic Relationship Status, Quality, and Depressive Symptoms Among Middle-Aged and Older Black Women
Authors: Hanus Stephanie L , Simons Leslie G , Lei Man-Kit , Cobb Ryon J , Simons Ronald L 
Published: January 2022

Abstract

Objectives
Past research has established a link between romantic relationships and depressive symptoms among adults, including those in later life. There is, however, still a lack of evidence regarding whether romantic relationship status or relationship quality is a better predictor of psychological well-being among middle-aged and older Black adult women.

Methods
The present study draws on data from the Family and Community Health Study, a multisite, longitudinal survey of health and psychosocial experiences of Black families, to examine how relationship status and quality relate to depressive symptoms among middle-aged and older Black adult women (N = 571). A series of negative binomial regression models, with 95% confidence intervals and internal moderators, were used to assess the research questions.

Results
Middle-aged and older Black women in married, cohabiting, and dating relationships who reported higher levels of relationship quality had a lower likelihood of depressive symptoms than those who reported lower levels of relationship quality or who did not report being in any romantic relationship when controlling for baseline depressive symptoms. The findings from our study indicate that relationship quality is a better predictor of depressive symptoms than relationship status.

Discussion
Our findings extend the body of literature on the impact of romantic relationships on individual well-being and provide compelling evidence that such relationships, particularly those of high quality, are significantly associated with lower depressive symptoms among middle-aged and older Black women.
Seismicity modulation in a 3-D rate-and-state interacting fault population model
Authors: Dublanchet P 
Published: January 2022

SUMMARY
Seismicity rate is sometimes observed to correlate with periodic stress oscillations, such as seasonal changes in hydrological loads, or solid-earth and oceanic tidal stresses. However, seismicity modulation is far from being systematic, often weak and the mechanical control is not yet fully understood. Here, a 3-D interacting fault population loaded by a periodic stress has been studied. For that a new earthquake simulator coupling rate-and-state friction and 3-D quasi-dynamic elasticity has been developed, and used to explore the mechanical conditions leading to seismicity modulation. It is first shown that seismicity modulation is maximized when the amplitude of periodic loading stress approaches aσ, a being the viscous parameter of the rate-and-state friction and σ the normal stress in the earthquake source region. The mode of modulation is frequency dependent: short loading periods lead to a stress control (seismicity rate follows the Coulomb stress) while longer periods lead to stressing rate control (seismicity rate tracks Coulomb stressing rate variations). An analytical expression for the critical period Tc separating the two regimes is derived from Dieterich’s theory, showing a dependence of the transition on Coulomb stress amplitude. Finally, the average seismicity rate either scales exponentially with Coulomb stress (stress control), or linearly with Coulomb stressing rate (stressing rate control), as suggested by Dieterich’s theory. These features indicate that for the range of parameters explored, stress redistribution within the fault population is a second order effect in the seismicity modulation, which is primarily controlled by the properties of remote loading. This paper therefore confirms with numerical simulations the Coulomb stress and stressing rate control of seismicity rate, and the limited importance of stress redistribution in controlling earthquake production anticipated by previous theoretical studies.
Deregulation of microtubule organization and RNA metabolism in Arx models for lissencephaly and developmental epileptic encephalopathy
Authors: Drongitis Denise , Caterino Marianna , Verrillo Lucia , Santonicola Pamela , Costanzo Michele , Poeta Loredana , Attianese Benedetta , Barra Adriano , Terrone Gaetano , Lioi Maria Brigida , Paladino Simona , Di Schiavi Elia , Costa Valerio , Ruoppolo Margherita , Miano Maria Giuseppina 
Published: January 2022

Abstract
X-linked lissencephaly with abnormal genitalia (XLAG) and developmental epileptic encephalopathy-1 (DEE1) are caused by mutations in the Aristaless-related homeobox (ARX) gene, which encodes a transcription factor responsible for brain development. It has been unknown whether the phenotypically diverse XLAG and DEE1 phenotypes may converge on shared pathways. To address this question, a label-free quantitative proteomic approach was applied to the neonatal brain of Arx knockout (ArxKO/Y) and knock-in polyalanine (Arx(GCG)7/Y) mice that are respectively models for XLAG and DEE1. Gene ontology and protein–protein interaction analysis revealed that cytoskeleton, protein synthesis and splicing control are deregulated in an allelic-dependent manner. Decreased α-tubulin content was observed both in Arx mice and Arx/alr-1(KO) Caenorhabditis elegans ,and a disorganized neurite network in murine primary neurons was consistent with an allelic-dependent secondary tubulinopathy. As distinct features of Arx(GCG)7/Y mice, we detected eIF4A2 overexpression and translational suppression in cortex and primary neurons. Allelic-dependent differences were also established in alternative splicing (AS) regulated by PUF60 and SAM68. Abnormal AS repertoires in Neurexin-1, a gene encoding multiple pre-synaptic organizers implicated in synaptic remodelling, were detected in Arx/alr-1(KO) animals and in Arx(GCG)7/Y epileptogenic brain areas and depolarized cortical neurons. Consistent with a conserved role of ARX in modulating AS, we propose that the allelic-dependent secondary synaptopathy results from an aberrant Neurexin-1 repertoire. Overall, our data reveal alterations mirroring the overlapping and variant effects caused by null and polyalanine expanded mutations in ARX. The identification of these effects can aid in the design of pathway-guided therapy for ARX endophenotypes and NDDs with overlapping comorbidities.
A rare case of isolated accessory mitral tissue in an asymptomatic adult female
Authors: Rao Ying , Song Wenjuan , Wang Yu 
Published: January 2022

Abstract
Accessory mitral valve tissue (AMVT) is a rare congenital cardiac anomaly, which is associated with other congenital heart diseases. It is diagnosed in neonates or childhood and rarely in adulthood. Nevertheless, AMVT is an incidental finding or described as isolated. Echocardiography, especially three-dimensional echocardiography is considered as an optimal imaging technique for AMVT diagnosis. We herein presented an asymptomatic adult AMVT cases with significant left ventricular outflow tract obstruction and surgical excision was recommended.
Bulk–surface Lie splitting for parabolic problems with dynamic boundary conditions
Authors: Altmann Robert , Kovács Balázs , Zimmer Christoph 
Published: January 2022

AbstractThis paper studies bulk–surface splitting methods of first order for (semilinear) parabolic partial differential equations with dynamic boundary conditions. The proposed Lie splitting scheme is based on a reformulation of the problem as a coupled partial differential–algebraic equation system, i.e., the boundary conditions are considered as a second dynamic equation that is coupled to the bulk problem. The splitting approach is combined with bulk–surface finite elements and an implicit Euler discretization of the two subsystems. We prove first-order convergence of the resulting fully discrete scheme in the presence of a weak CFL condition of the form $\tau \leqslant c h$ for some constant $c&gt;0$. The convergence is also illustrated numerically using dynamic boundary conditions of Allen–Cahn type.
Two-point Landweber-type method with convex penalty terms for nonsmooth nonlinear inverse problems
Authors: Fu Zhenwu , Wang Wei , Han Bo , Chen Yong 
Published: January 2022

AbstractIn this work, we propose a two-point Landweber-type method with general convex penalty terms for solving nonsmooth nonlinear inverse problems. The design of our method can cope with nonsmooth nonlinear inverse problems or the nonlinear inverse problems whose data are contaminated by various types of noise. The method consists of the two-point acceleration strategy and inner solvers. Inner solvers are used to solve the minimization problems with respect to the penalty terms in each steps. If the minimization problems can be solved explicitly, the inner solvers will be chosen to be the exact solvers. Otherwise, we will use inexact solvers as inner solvers. Convergence results are given without utilizing the Gâteaux differentiability of the forward operator or the reflexivity of the image space. Numerical simulations are given to test the performance of the proposed method.
Association of the Kynurenine Pathway of Tryptophan Metabolism With Human Immunodeficiency Virus-Related Gut Microbiota Alterations and Visceral Adipose Tissue Accumulation
Authors: Gelpi M , Vestad B , Raju S C , Hansen S Hyll , Høgh J , Midttun Ø , Ueland P M , Ueland T , Benfield T , Kofoed Klaus F , Hov J R , Trøseid M , Nielsen S Dam 
Published: January 2022

Abstract

Background
The aim of the study was to investigate the association between human immunodeficiency virus (HIV)-related gut microbiota changes, alterations in the kynurenine (Kyn) pathway of tryptophan (Trp) metabolism, and visceral adipose tissue in the context of HIV infection.

Methods
Three hundred eighty-three people with HIV (PWH) were included from the Copenhagen comorbidity in HIV infection (COCOMO) study. Gut microbiota composition was analyzed by 16S ribosomal ribonucleic acid sequencing. Plasma metabolites were analyzed by liquid chromatography-tandem mass spectrometry. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were measured by single-slice computed tomography (CT) scan (4th lumbar vertebra).

Results
The HIV-related gut microbiota alterations were associated with lower Trp (β −.01; 95% confidence interval [CI], −0.03 to −0.00) and higher Kyn-to-Trp ratio (β 0.03; 95% CI, 0.01–0.05), which in turn was associated with higher VAT-to-SAT ratio (β 0.50; 95% CI, 0.10–0.90) and larger VAT area (β 30.85; 95% CI, 4.43–57.28). In mediation analysis, the Kyn-to-Trp ratio mediated 10% (P = .023) of the association between the VAT-to-SAT ratio and HIV-related gut microbiota.

Conclusions
Our data suggest HIV-related gut microbiota compositional changes and gut microbial translocation as potential drivers of high Kyn-to-Trp ratio in PWH. In turn, increased activity in the Kyn pathway of Trp metabolism was associated with larger visceral adipose tissue area. Taken together, our findings suggest a possible role for this pathway in the gut-adipose tissue axis in the context of HIV infection.
Increased Antibody Avidity and Cross-Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Variants by Hyperimmunized Transchromosomic Bovine–Derived Human Immunoglobulins for Treatment of Coronavirus Disease 2019
Authors: Tang Juanjie , Grubbs Gabrielle , Lee Youri , Wu Hua , Luke Thomas C , Egland Kristi A , Bausch Christoph L , Sullivan Eddie J , Khurana Surender 
Published: January 2022

Abstract
Passive antibody immunotherapeutics directed against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are promising countermeasures for protection and treatment of coronavirus disease 2019 (COVID-19). SARS-CoV-2 variants of concern (VOCs) and variants of interest (VOIs) can impact the clinical efficacy of immunotherapeutics. A fully human polyclonal antibody immunotherapeutic purified from plasma of transchromosomic (Tc) bovines hyperimmunized with SARS-CoV-2 WA-1 spike (SAB-185) is being assessed for efficacy in a phase 2/3 clinical trial when different circulating SARS-CoV-2 variants predominated. We evaluated antibody binding, avidity maturation, and SARS-CoV-2 VOCs/VOIs virus-neutralizing capacity of convalescent plasma compared with different lots of SAB-185 and individual Tc bovine sera sequentially obtained after each vaccination against Alpha, Epsilon, Iota, Gamma, Beta, Kappa, and Delta variants. In contrast to convalescent plasma, sera and SAB-185 derived from hyperimmunized Tc bovines demonstrated higher antibody avidity and more potent cross-neutralizing activity of VOCs/VOIs. Thus, SAB-185 is a potential promising therapeutic candidate for the treatment of patients infected with SARS-CoV-2 variants.
Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review
Authors: Miller Muska , Singer Mervyn 
Published: January 2022

Abstract
While antibiotics are clearly important treatments for infection, antibiotic-induced modulation of the immune system can have detrimental effects on pathogen clearance and immune functionality, increasing the risk of secondary infection. These injurious consequences may be mediated, at least in part, through effects on the mitochondria, the functioning of which is already compromised by the underlying septic process. Here, we review the complex interactions between antibiotic administration, immune cell and mitochondrial dysfunction.
Using telehealth consultations for healthcare provision to patients from non-Indigenous racial/ethnic minorities: a systematic review
Authors: Truong Mandy , Yeganeh Ladan , Cook Olivia , Crawford Kimberley , Wong Pauline , Allen Jacqueline 
Published: January 2022

Abstract

Objective
The COVID-19 pandemic has seen a rapid adoption of telehealth consultations, potentially creating new barriers to healthcare access for racial/ethnic minorities. This systematic review explored the use of telehealth consultations for people from racial/ethnic minority populations in relation to health outcomes, access to care, implementation facilitators and barriers, and satisfaction with care.

Materials and Methods
This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis and the Joanna Briggs Institute Manual for Evidence Synthesis. Five major databases were searched to identify relevant studies. Screening, full-text review, quality appraisal, and data extraction were all completed independently and in duplicate. A convergent integrated approach to data synthesis was applied with findings reported narratively.

Results
A total of 28 studies met the inclusion criteria. Telehealth-delivered interventions were mostly effective for the treatment/management of physical and mental health conditions including depression, diabetes, and hypertension. In several studies, telehealth improved access to care by providing financial and time benefits to patients. Technological difficulties were the main barriers to effective telehealth consultation, although overall satisfaction with telehealth-delivered care was high.

Discussion
Telehealth-delivered care for racial/ethnic minorities offers promise across a range of conditions and outcomes, particularly when delivered in the patient’s preferred language. However, telehealth may be problematic for some due to cost and limited digital and health literacy.

Conclusion
The development and implementation of guidelines, policies, and practices in relation to telehealth consultations for racial/ethnic minorities should consider the barriers and facilitators identified in this review to ensure existing health disparities are not exacerbated.
Effect of Different Constant Temperatures on Life History and Life Table Parameters of Trichogramma euproctidis (Hymenoptera: Trichogrammatidae)
Authors: Tabebordbar Fatemeh , Shishehbor Parviz , Ebrahimi Ebrahim , Polaszek Andrew , Ugine Todd A 
Published: January 2022

Abstract
Temperature has a profound effect on performance and behavior of egg parasitoids. Egg parasitoids are a well-known alternative for the control of lepidopterous pests. Selected life history parameters of Trichogramma euproctidis (Girault) (Hymenoptera: Trichogrammatidae), an established egg parasitoid species in Khuzestan- Southwest Iran, were appraised at eight constant temperatures (22.5, 25, 27.5, 30, 32.5, 35, 37.5, and 40°C) using Ephestia kuehniella Zeller (Lepidoptera: Pyralidae) eggs as the host. We found significant effects of temperature on the number of parasitized eggs, development time, sex ratio, progeny’s longevity, and fecundity. T. euproctidis developed on E. kuehniella eggs at all temperatures tested, but performed best at 32.5°C. At this temperature, they parasitized the most eggs, produced the most female progeny, and had high rates of survival. Our findings revealed that temperature significantly affected the longevity of female progeny and fecundity of T. euproctidis. A life table analysis confirmed that temperature resulted in optimal effects on T. euproctidis life history. Net reproductive rate (R0) of T. euproctidis was different among the temperatures tested. The intrinsic rate of increase (r) was positively correlated with temperature from 22.5 to 32.5°C and then decreased from 35 to 40°C. Generation time (T) and doubling time (DT) decreased as temperature increased from 22.5 to 37.5°C and then increased at 40°C. These data suggest that this strain of T. euproctidis is adapted to high temperatures and harsh environmental conditions and has the potential to be used in integrated management programs in Southwest Iran.
Black Pecan Aphid (Hemiptera: Aphididae) Management on Pecan When Gibberellic Acid Is Applied Concurrently With Broad-Spectrum Insecticides
Authors: Cottrell Ted E 
Published: January 2022

Abstract
Aphids (Hemiptera: Aphididae) are serious pests of pecan foliage (Carya illinoinensis [Wangenh.] K. Koch). The black pecan aphid, Melanocallis caryaefoliae (Davis) (Hemiptera: Aphididae), feeds on pecan foliage and elicits leaf chlorosis that can cause defoliation. In contrast, the blackmargined aphid, Monellia caryella (Fitch) (Hemiptera: Aphididae), and yellow pecan aphid, Monelliopsis pecanis Bissell (Hemiptera: Aphididae), feed on pecan foliage but do not elicit chlorotic feeding injury. Application of gibberellic acid (GA3) to pecan foliage reduces chlorotic foliar injury and nymphal populations of the black pecan aphid. GA3 has potential to manage black pecan aphid later in the season when broad-spectrum insecticides are used to control direct pests of pecan nuts but also inadvertently induce aphid outbreaks. Here, broad-spectrum insecticides were used with GA3 or aphicides in orchard trials for 2 yr. Populations of aphids and natural enemies along with chlorotic feeding injury on foliage were assessed. When used concurrently with GA3 or aphicides, broad-spectrum insecticides did not flare black pecan aphid populations. However, combined populations blackmargined aphids and yellow pecan aphids were higher in treatments with GA3 than with an aphicide or in the control treatment during one of two years. Application of GA3 or the aphicide often led to significantly less chlorotic injury than observed in the control. Surprisingly, natural enemies were not significantly affected by broad-spectrum insecticides when applied concurrently with GA3. These results show that GA3 can be used as part of a late-season IPM strategy to protect foliage from localized chlorotic leaf injury elicited by the black pecan aphid.
Intra- and Interspecific Variation in the Susceptibility to Insecticides of Stink Bugs (Hemiptera: Pentatomidae) That Attack Soybean and Maize in Southern Brazil
Authors: Steinhaus Eduardo A , Warpechowski Luiz F , Braga Luiz E , Morin Manuel , Tenório Camila , Boff Jéssica S , Bernardi Oderlei , Farias Juliano R 
Published: January 2022

Abstract
This study evaluated intra- and interspecific variation regarding the susceptibility to insecticides of key pentatomid pests of soybean (Glycine max L.) and maize (Zea mays L.) crops in Brazil. To perform bioassays, populations of Euschistus heros (F.), Diceraeus (=Dichelops) furcatus (F.), Nezara viridula (L.), and Piezodorus guildinii (Westwood) (Hemiptera: Pentatomidae) were collected in soybean fields in Southern Brazil during the 2020/2021 crop season. Then, stink bugs were exposed to doses of commercial insecticides commonly applied for its control in dip-test bioassays using fresh green bean pods. In general, all stink bug species and populations studied were susceptible to acephate, acetamiprid + bifenthrin, imidacloprid + bifenthrin, and ethiprole, with mortality rates &gt; 80%. Most populations of E. heros and D. furcatus, considered the main stink bugs that attack soybean and maize, respectively, presented low or intermediate susceptibility to acetamiprid + α-cypermethrin, ζ-cypermethrin + bifenthrin, dinotefuran + λ-cyhalothrin, and bifenthrin + carbosulfan. Except for bifenthrin + carbosulfan (mortality &lt; 57%), secondary stink bugs species that attack soybean (N. viridula and P. guildinii) showed pronounced susceptibility to all insecticides tested, with mortality rates &gt; 70%. In summary, the populations of E. heros and D. furcatus showed diminished susceptibility to various insecticides formulated with the mixture of neonicotinoids + pyrethroids, whereas N. viridula and P. guildinii were most susceptible to the insecticides evaluated. The implications of these findings to integrated and resistance management programs are discussed.
Genetic Diversity and Wolbachia (Rickettsiales: Anaplasmataceae) Prevalence Within a Remnant Population of Regal Fritillary, Argynnis idalia (Lepidoptera: Nymphalidae), in South-Central Pennsylvania
Authors: Rutins Ilga , Schannauer Sarah , Orellana Sharil , Laukhuff Harrison , Lang Eric , Becker Timothy , McKinney Erika , Thomas Kayli , Tilden Virginia , Swartz Mark , Blair Jaime E 
Published: January 2022

Abstract
Eastern populations of the North American regal fritillary, Argynnis idalia Drury (1773), have been largely extirpated over the past half century. Here we report on the last remaining population of eastern regal fritillaries, located within a military installation in south-central Pennsylvania. Samples were obtained from field specimens during two years of annual monitoring, and from females collected for captive rearing over a five year period. Nuclear microsatellite and mitochondrial sequence data do not suggest subdivision within this population, but excess nuclear homozygosity indicates negative impacts on genetic diversity likely due to small population size and potential inbreeding effects. Molecular assays did not detect Wolbachia endosymbionts in field specimens of regal fritillary, but sympatric Argynnis sister species showed high prevalence of Wolbachia infected individuals. Our results inform ongoing conservation and reintroduction projects, designed to protect the last remaining regal fritillary population from extirpation in the eastern United States.
Spontaneous haemorrhage of chronic varicose ulceration causing ischaemic colitis
Authors: Holt Jonathon 
Published: January 2022

Abstract
Venous ulcers are common and account for the majority of lower limb chronic wounds. Complications may be serious in nature and although haemorrhage is rare, it may be rapidly fatal. The case of a female patient who presented with a spontaneous varicose ulcer haemorrhage causing hypovolaemic ischaemic colitis is described. This case exemplifies the need to identify and manage the development of venous insufficiency before progression to chronic wounds or other disease burdens which may be fatal or life-altering.
A Rational Approach to Coagulation Testing
Authors: Marin Maximo James , Harris Neil , Winter William , Zumberg Marc Stuart 
Published: January 2022

AbstractQuality patient care requires the appropriate selection of laboratory tests. Irrelevant testing must be avoided, whereas pertinent testing is indispensable. The goals of this review are 3-fold: (1) to describe appropriate coagulation test selection for medical and surgical patients, (2) to describe appropriate coagulation testing specifically in individuals infected with SARS-CoV-2 causing COVID-19, and (3) to define the rational use of anticoagulant monitoring.