bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variations of the surface characteristics of Ryugu returned samples
Authors: NAKATO Aiko , Yada Toru , Nishimura Masahiro , Yogata Kasumi , Miyazaki Akiko , Nagashima Kana , Hatakeda Kentaro , Kumagai Kazuya , Hitomi Yuya , Soejima Hiromichi , Bibring Jean-Pierre , Pilorget Cedric , Hamm Vincent , Brunetto Rosario , Riu Lucie , Lourit Lionel , Loizeau Damien , Pivert-Jolivet Tania Le , Lequertier Guillaume , Moussi-Soffys Aurelie , Abe Masanao , Okada Tatsuaki , Usui Tomohiro , Nakazawa Satoru , Saiki Takanao , Tanaka Satoshi , Terui Fuyuto , Yoshikawa Makoto , Watanabe Sei-ichiro , Tsuda Yuichi 
Published: August 2022

Abstract
Hayabusa2 spacecraft successfully collected rock samples through two touchdowns from the surface of C-type near-Earth asteroid 162173 Ryugu and brought them back to Earth in 2020. At the Extraterrestrial Sample Curation Center in JAXA, we performed initial description to all samples to obtain the fundamental information and prepare the database for sample allocation. We propose morphological classifications for the returned samples based on the initial description of 205 grains described in the first 6 months. The returned samples can be distinguished by four morphological characteristics: dark, glossy, bright, and white. According to coordinated study of initial description and detailed investigation by scanning electron microscopy and X-ray diffraction analysis in this study, these features reflect the differences in the degree of space weathering and mineral assemblages. The degree of space weathering of the four studied grains is heterogeneous: weak for A0042 (dark group) and C0041 (white group); moderate for C0094 (glossy); and severe for A0017 (bright). The white phase in a grain belonging to white group is identified as large carbonate minerals. This is the first effort to classify Ryugu returned samples. Based on these results, researchers can estimate sample characteristics only from the information on the JAXA curation public database. It could be an important reference for sample selection for further investigation.
A Persistent Cyclical Pattern in the Soi and Eqsoi Series
Authors: Gil-Alana Luis Alberiko , Romero-Rojo Maria Fatima 
Published: August 2022

Abstract
This paper deals with the analysis of the SOI and EQSOI series and their statistical properties, focussing in particular in their cyclical pattern and its persistence across time. For this purpose, we use a long memory model that is characterized because the spectral density function is unbounded at a frequency away from zero. Our results indicate that the two series display a long memory pattern, with the order of integration in the interval (0, 0.5) and the length of the cycles ranging between three and four years.JEL Classification: C00; C02; C22; Q54;
A randomised feasibility study of serial magnetic resonance imaging to reduce treatment times in Charcot neuroarthropathy in people with diabetes (CADOM)
Authors: Gooday Catherine , Game Frances , Woodburn Jim , Poland Fiona , Sima Erika , Dhatariya Ketan , Shepstone Lee , Barton Garry , Hardeman Wendy 
Published: August 2022

Abstract
Aim This study aims to explore the feasibility of using serial MRI without contrast in the monitoring of Charcot neuroarthropathy to reduce duration of immobilisation of the foot, in order to decide whether a large-scale trial is warrantedMethodsA multicentre, randomised, prospective, two arm, open, feasibility study (CADOM) of people with diabetes with a suspected or confirmed diagnosis of Charcot neuroarthropathy . Participants were randomised (1:1) to ‘standard care plus’, including repeated foot temperature measurements and X-rays, or the intervention arm, with additional three-monthly MRI, until remission of Charcot neuroarthropathy or a maximum 12 months (active phase). Participants were then followed-up for a further six months, post remission to monitor for relapse of the Charcot neuroarthropathy (follow-up phase). Feasibility outcomes were recruitment, retention, data completeness and safety of the intervention MRI. We also collected clinical, and patient reported outcomes, and data on health and social care usage to inform a future cost effectiveness analysis.ResultsOne-hundred and five people were assessed for eligibility at five sites. 64/105 potential participants meet the eligibility criteria to participate in the study Forty-three participants were randomised: 20 to standard care plus and 23 to MRI intervention. The main reason for ineligibility was a previous episode of Charcot neuroarthropathy . Thirteen participants were withdrawn post-randomisation due to an alternative diagnosis being made diagnosis. Of the remaining 30 participants, 19 achieved remission, 6 had not gone into remission at the end of the 12-month active phase so exited the study. Five participants were lost to follow-up. Of the MRIs that were not disrupted by COVID-19 pandemic 26/31 (84%) were completed. As this was a feasibility study it was not designed to test the effectiveness of serial MRI in diagnosing remission. However, there was no statistical difference in the time in off-loading device between the two arms of the study: Hazard Ratio (HR) 0.405 (95% CI 0.140-1.172), p=0.096 .DiscussionThe findings support a definitive randomised controlled trial to evaluate the effectiveness of MRI in diagnosing remission in Charcot neuroarthropathy. The rates of recruitment, retention, data, and MRI completeness show that a definitive study is feasible.Study registration ISRCTN, 74101606. Registered on 6 November 2017.http://www.isrctn.com/ISRCTN74101606?q=CADom&filters=&sort=&offset=1&totalResults=1&page=1&pageSize=10&searchType=basic-search
Hessian-based weighted guided image filtering
Authors: Wu Jiaxin , Xie Shoulie , Cao Wei , Wu Shiqian 
Published: August 2022

Abstract

Guided image filtering (GIF) is a popular edge-preserving smoothing technique, and the regularization parameter selection plays an important role in the performance of GIF. In this paper, we propose a new guided image filter based on Hessian matrix which consists of the second-order derivatives of an image. More specifically, a new structural measurement index is introduced by using the eigenvalues of the Hessian matrix first, which can distinguish the texture and flat regions of the image. Then the regularization parameter is adjusted based on this Hessian-based second-order structure measurement index, that is, a large regularization parameter is selected to improve the smoothness of the flat regions, while a small regularization parameter is set for the texture regions to preserve the image structure such as edges and corners. To further improve the quality of the filtered images, we also introduce a weighted averaging technique to the linear filter coefficients based on local variance. Experimental results show that the proposed Hessian-based weighted guided image filtering (HWGIF) method outperforms the state-of-the-art approaches in image processing applications such as edge-preserving denoising, detail enhancement, dehazing and HDR compression.
“Shelter My Soul with Your Body” – A Burial Custom Influenced by Shamanism: A Case of Covering a Dead Face with the Right Ribs of a Local Sheep in Inner Mongolia, China
Authors: Ban Lin , Lv Xiaohong , Cai Dawei , Liu Yiwen , Che Haoyu , Wang Chunxue , Cao Jianen , Zhang Zhe 
Published: August 2022

Abstract
Death represents the termination of all biological functions that sustain an organism and is inevitable in the ordinary life of people. Throughout history, death has been a topic of discussion. The emotion of fear of death has existed since the birth of human beings and has become even more so after civilization. To alleviate the fear of death, the unknown thing, primitive people began to explain death with their own world outlook; thus, the primitive concept of soul and religion came into being. Death is accompanied by the soul, and the fear of death gradually evolved into the awe of the soul, which gradually turned to practical action under the catalysis of primitive religion. Humans began to express their feelings (veneration or contempt) for the deceased in various practical behaviours and rituals that evolved into many fixed forms of burial or sacrificial customs after death. Shamanism is one of them. It is popular among nomadic groups in northern Eurasia, where many archaeological studies of shamanism have been conducted. This paper examined the phenomenon of covering a dead face with all the right ribs of a sheep at Nairentaoligai (乃仁陶力盖)Cemetery M17 in Inner Mongolia, China. These ribs were carefully researched by zooarchaeological methods, and we defined the basic information about the sheep. Then, we recovered the dismemberment process of the sheep by observing the traces on the bone surface and found that the dead face was covered by all the right ribs of a sheep in this tomb. This may have been to practice a particular idea. In connection with the shamanism culture prevalent in the area, we consider that this act may have been intended to declare the death of the body and shelter the soul of the dead from intrusion. This reflects shamanism culture on burial customs. This discovery is of great significance for the research of religious beliefs and death views of the northern nomadic people of the Mongolian Plateau region.
Demoralization profiles and their association with depression and quality of life in Chinese patients with cancer: A latent class analysis
Authors: Lin Fumei , Hong Yuting , Lin Xiujing , Chen Qingqin , Lin Yu-an , Chen Qiuhong , Huang Feifei 
Published: August 2022

Abstract
PurposeThe study aimed to identify latent classes of demoralization and examine their association with depression and with quality of life (QOL) among patients with cancer.MethodsCross-sectional data from 874 patients with cancer from three tertiary hospitals in Fujian province were collected using a convenience sampling method. Demoralization, depression, and QOL were assessed using the Chinese version of the Demoralization Scale-II, Patient Health Questionnaire-9, and McGill Quality of Life Questionnaire. Latent class analysis was performed on demoralization profiles. Binary logistic regression and multiple stepwise linear regression were used to examine the identified classes’ associations with depression and QOL.ResultsThree latent classes of demoralization were identified: the “low demoralization and emotional disturbance” class (Class 1; 49.6%); “moderate demoralization and meaninglessness” class (Class 2; 29.1%); and “high demoralization and existential despair” class (Class 3; 21.3%). The severity of depression increased and the levels of QOL decreased with the three classes of demoralization. Patients with cancer in Classes 1 and 2 were 0.128 and 0.018 times more likely to be depressed than those in Class 3, respectively, whereas the magnitudes of decrease in QOL scores for Classes 2 and 3 were 0.378 and 0.629, respectively. ConclusionThis study revealed three heterogeneous classes of demoralization in Chinese patients with cancer and indicated that increased classes were associated with more severe depression and decreased QOL. Targeted, step-by-step psychological interventions should be developed and implemented according to the characteristics of each class of demoralization to effectively promote psychological well-being among patients with cancer.
Disulfiram Alleviates Acute Lung Injury and Related Intestinal Mucosal Barrier Impairment by Targeting GSDMD-Dependent Pyroptosis
Authors: Zhao Jiping , Wang Hong , zhang Jintao , Ou Fuwei , Wang Junfei , Liu Tian , Wu Jinxiang 
Published: August 2022

Abstract
Background: Pyroptosis was implicated in acute lung injury (ALI). Disulﬁram is reported as an effective pyroptosis inhibitor by inhibiting gasdermin D(GSDMD). However, the function of pyroptosis executor GSDMD and treatment of disulﬁramon on ALI, especially whether it was involved in ALI-associated intestinal mucosal barrier impairment remains unclear. This study aims to explore the role of pyroptosis and disulﬁram’ treatment on ALI and related intestinal mucosal barrier impairment.Methods: First, we established lipopolysaccharide (LPS)-induced ALI models in wild-type and Gsdmd knockout (Gsdmd−/−), to detect the effect of pyroptosis on ALI-related intestinal mucosal barrier impairment. Furthermore, we used wild-type mice treated with disulﬁram to investigate the treatment of disulﬁram on ALI and related intestinal mucosal barrier impairment. Results: The data showed that GSDMD-mediated pyroptosis was activated in both lung and intestinal mucosa tissues in LPS-induced ALI, and deficiency of Gsdmd ameliorated LPS-induced ALI and related intestinal mucosal barrier damage. We also disclosed that disulﬁram inhibited the pyroptosis level, and alleviated ALI and related intestinal mucosal barrier impairment induced by LPS.Conclusions: These ﬁndings suggested the role of GSDMD-mediated pyroptosis and the potential application treatment of disulﬁram in ALI and related intestinal mucosal barrier damage.
Chemical shift assignments of a fusion protein comprising the C-terminal-deleted hepatitis B virus X protein BH3-like motif peptide and Bcl-xL
Authors: Kusunoki Hideki , Hamaguchi Isao , Kobayashi Naohiro , Nagata Takashi 
Published: August 2022

Abstract
Chronic hepatitis B virus (HBV) infection is a major risk factor for the development of liver diseases including fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). HBV has the multifunctional protein, HBV X protein (HBx, 154 residues), which plays key roles in HBV replication and liver disease development. Interaction of HBx through its BH3-like motif with the anti-apoptotic protein Bcl-xL leads to HBV replication and induction of apoptosis, resulting in HCC development. Our previous nuclear magnetic resonance (NMR) study revealed that the HBx BH3-like motif peptide (residues 101–136) binds to the common BH3-binding groove of Bcl-xL. Importantly, a C-terminal-truncated HBx, e.g., residues 1–120 of HBx, is strongly associated with the increased risk of HBV-related HCC development. However, the interaction mode between the C-terminal-truncated HBx and Bcl-xL remains unclear. To elucidate this interaction mode, the C-terminal-deleted HBx BH3-like motif peptide (residues 101–120) was used as a model peptide in this study. To facilitate the NMR analysis, we prepared a fusion protein of HBx(101–120) and Bcl-xL connected with five repeats of the glycine-serine dipeptide as a linker. Here, we report the 1H, 13C, and 15N resonance assignments of the fusion protein. This is the first step for the elucidation of the pathogenesis of liver diseases caused by the interaction between the C-terminal-truncated HBx and Bcl-xL.
Long-Term Outcomes of Revisional One anastomosis Gastric Bypass Post Laparoscopic Sleeve Gastrectomy
Authors: Sabah Salman Al , Haddad Eliana Al , Al-Subaie Saud , Ekrouf Shehab , Almulla Ahmad , Alhaddad Mohannad , Aljabal Mais Shiekh , Alenezi Khaled 
Published: August 2022

Abstract
Purpose
Revisional bariatric surgeries following laparoscopic sleeve gastrectomy’s (LSG) have demonstrated a dramatic increase worldwide. Recently, one-anastomosis gastric bypass (OAGB) has become a contender as an appropriate revisional procedure, however, no long-term data currently exist on the effectiveness of it as a revisional surgery post-LSG.
Methods
A retrospective analysis was performed on all patients who underwent LSG at a public hospital in Kuwait from 2008–2017. A list was obtained of those who underwent revisional OAGB surgery after initial LSG, after which a phone survey was performed and their demographics were analyzed.
Results
A total of 29 patients underwent revisional OAGB post-initial LSG, of which 89.7% were female. Prior to LSG, the mean weight of the patients was 127.5Kg and the mean BMI was 49.0Kg/m2. The mean weight loss after initial LSG was 43.8kg; while the average duration until patients underwent revisional SAGB was 5.3 years. The cause for revision was weight regain (86.2%), or inadequate weight loss (13.8%). Prior to undergoing revisional OAGB, the weight and BMI of the patients was 110.9kg and 42.4Kg/m2 respectively. This demonstrated a %excess weight loss of 14.5%, 31.9%, 48.0%, 56.3%, 57.2%, and 54.7% at 2 weeks, 3 months, 6 months, 1-year post, 4-years and 5-years post-OAGB, respectively. Twelve morbidities were reported during the follow-up period.
Conclusion
Revisional bariatric surgery is technically demanding and may be associated with a high complication rate. However, OAGB as a revisional procedure has proven to be safe and effective in the long-term outcomes of patients that undergo it post-LSG.
Does adding vaginal oestradiol after oral oestradiol facilitate artificial autologous freeze-thaw embryo transfer cycles? A retrospective cohort study
Authors: Li Ran , Wu Hai-Cui , Xiang Shan , Jia Zhi-Cheng , Lian Fang , Guo Ying 
Published: August 2022

Abstract
Research question: This study investigates the difference in reproductive outcomes with the late addition of vaginal oestradiol to oral oestradiol in artificially cycled frozen embryo transfer (AC-FET) cycles. Design: This retrospective cohort study was conducted at a university-affiliated tertiary care hospital. We divided 806 infertility patients who underwent programmed pre-FET endometrial preparation from January 2018 to July 2021 into two independent groups: Group A (591 with oral estradiol valerate only) and group B (215 with late oral estradiol valerate plus vaginal 17 β-estradiol). The primary outcome was the live birth rate (LBR), and the secondary outcome was other pregnancy-related outcomes. Propensity score matching (PSM) and multivariate logistic regression were applied to analyze all pregnancy outcomes, with a subgroup analysis based on vaginal oestradiol dose for group B. A subanalysis of cycles with endometrial thickness < 8 mm on the day prior to progesterone was also performed to assess the effect of adding vaginal oestradiol late in the thin endometrial transplantation cycle on reproductive outcomes.Results: Before and after PSM analysis, the live birth rates in group A were 41.1% and 42.2%, significantly higher than 31.2% and 30.8% in group B (P=0.015), respectively. Multiple logistic regression analysis demonstrates that group B was less likely to have a live birth than group A (OR 0.643, 95% Cl 0.453-0.913, P=0.014). Subgroup analysis of group B according to vaginal oestradiol dose demonstrated an insignificant difference in live birth rates between the subgroups (42.6% vs. 26.8% vs. 34.6%, P=0.118). In thin endometrial transplant cycles with an endometrial thickness < 8 mm on the day prior to progesterone, live birth rates were similar in both groups (36.9% vs. 26.8%, P=0.234).Conclusion: The addition of vaginal oestradiol as part of an artificial endometrial preparation (AEP) at a late stage of oral oestradiol significantly reduced LBR in autologous frozen-thawed embryo transfer, is independent of the dose of vaginal oestradiol, and does not improve the reproductive outcome in thin endometrial transfer cycles. However, more well-designed randomized clinical trials merit further investigation to confirm this conclusion.
Computing optimal drug dosing with OptiDose - Implementation in NONMEM
Authors: Bachmann Freya , Koch Gilbert , Bauer Robert , Szinnai Gabor , Pfister Marc , Steffens Britta 
Published: August 2022

Abstract
Finding a drug dosing recommendation with a PKPD model for an individual or a target population can be a laborious and complex task. Recently, an optimal dosing algorithm (OptiDose) was developed to compute the optimal doses for any pharmacometrics / PKPD model for a given dosing scenario. In this work, we reformulate the underlying optimal control problem and elaborate how to solve it with standard commands in the software NONMEM. To demonstrate the potential of the OptiDose implementation in NONMEM, four relevant but substantially different optimal dosing tasks are solved. In addition, the impact of different dosing scenarios as well as the choice of the therapeutic goal on the computed optimal doses are discussed.
Identification of a novel intronic variant of ATP6V0A2 in a Han-Chinese family with Cutis Laxa
Authors: Shu Jianbo , Zhang Ying , Zhao Yiran , Zhang Fang , Liu Yang , Cai Chunquan 
Published: August 2022

Abstract
Background
Cutis laxa is a connective tissue disease caused by abnormal synthesis or secretion of skin elastic fibers, leading to skin flabby and sagging in various body parts. It can be divided into congenital cutis laxa and acquired cutis laxa, and inherited cutis laxa syndromes is more common in clinic.
Methods
In this study, we reported a case of a Han-Chinese male baby with ATP6V0A2 gene variant leading to cutis laxa. The proband was identified by whole-exome sequencing to determine the new variant, and their parents were verified by sanger sequencing. Bioinformatics analysis and minigene assay were used to verify the effect of this variant on splicing function.
Results
The main manifestations of the proband are skin laxity, abnormal facial features, and enlargement of the anterior fontanelle. Whole-exome sequencing showed that the baby carried a non-canonical splicing-site variant c.117 + 5G > T, p. (?) in ATP6V0A2 gene. Sanger sequencing showed that both parents of the proband carried the heterozygous variant. The results of bioinformatics analysis and minigene assay displayed that the variant site affected the splicing function of pre-mRNA of ATP6V0A2 gene.
Conclusions
In this study, it was identified that ATP6V0A2 gene c. 117 + 5G > T may be the cause of the disease. Few non-canonical splicing variants of ATP6V0A2 gene were reported in the past, and this variant expands the variants spectrum of the gene. The functional study of minigene assay plays a certain role in improving the evidence level of splicing variants, which lays a foundation for prenatal counseling and follow-up gene therapy.
Epidemiology of in-hospital burn patients in a tertiary hospital in Damascus, Syria.
Authors: Torbey André , Shibani Mosa , Alzabibi Mhd Amin , Eddin Ahmad Saad , Ammar Ali 
Published: August 2022

Abstract
Background
According to the WHO, 300,000 people die every year as a result of burn injuries. In this study, we aim to discuss the epidemiology and outcomes of burn patients who were admitted to Al Mowasat hospital in Damascus, Syria.
Methods
A retrospective cohort research was conducted from January 2017 to December 2021. All accessible paper-based medical records of burn injury patients admitted to the hospital were evaluated. ABSI score was used to classify injury degree. Chi-square test and logistic regression model were used to study the association between demographic variables and outcomes.
Results
Of the 641 patients, 367 (57.3%) were male and 274 (42.7%) were female. Children represented more than half of our sample 377 (58.8%). The most common cause of burn was flame burns 393 (61.3%), followed by scalding 199 (31.0%). Most of the patients had a more than 10% TBSA of burns 511(79.7%). Children had higher rates of leaving against medical advice (25.7%) than adults (17.8%). Children and patients who needed respiratory support were more likely to die than others 2.545 (1.079–6.004), 9.208 (4.061–20.879), respectively.
Conclusion
The situation of burn patients in Syria requires more attention and care to reduce mortality and morbidity. Focusing on the young age group to prevent such life-limiting injuries should be a priority.