bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereotactic radiosurgery for post operative brain metastasic surgical cavities: a single institution experience
Authors: Cantaloube Marie , Boucekine Mohamed , Balossier Anne , Muracciole Xavier , Meyer Mickael , Delsanti Christine , Carron Romain , Beltaifa Yassine Mohamed , Figarella-Branger Domnique , Regis Jean , Padovani Laetitia 
Published: September 2022

Abstract
Background
The standard therapy for brain metastasis was surgery combined with whole brain radiotherapy (WBRT). The latter is however, associated with important neurocognitive toxicity. To reduce this toxicity, postoperative stereotactic radiosurgery (SRS) is a promising technique. We assessed the efficacy and the tolerance to postoperative Gamma Knife radiosurgery (GK) on the tumor bed after resection of brain metastases.

Methods
Between February 2011 and December 2016, following macroscopic complete surgical resection, 64 patients and 65 surgical cavities were treated by GK in our institution. The indication for adjuvant radiosurgery was a multidisciplinary decision. The main assessment criteria considered in this study were local control, intracranial metastasis-free survival (ICMFS), overall survival and toxicity.

Results
Median follow-up: 11.1 months. Median time between surgery and radiosurgery: 35 days. Median dose was 20 Gy prescribed to the 50% isodose line, for a median treated volume of 5.6 cc. Four patients (7%) suffered from local recurrence. Local recurrence-free, intracranial recurrence-free and overall survival at 1 year were 97.5%, 57.6% and 62.4% respectively. In total, 23 patients (41%) suffered from intracranial recurrence outside the tumor bed. In univariate analysis: concomitant GK treatment of multiple lesions and the tumor bed was associated with a decrease in ICMFS (HR = 1.16 [1.005–1.34] p = 0.04). In multivariate analysis: a non-lung primary tumor was significantly associated with a decrease in ICMFS (HR = 8.04 [1.82–35.4] p = 0.006). An increase in performance status (PS) and in the initial number of cerebral metastases significantly reduced overall survival (HR = 5.4 [1.11–26.3] p = 0.037, HR = 2.7 [1.004–7.36] p = 0.049, respectively) and One radiation necrosis histologically proven.

Conclusion
Our study confirmed that postoperative GK after resection of cerebral metastases is an efficient and well-tolerated technique, to treat volumes of all sizes (0.8 to 40 cc). Iterative SRS or salvage WBRT can be performed in cases of intracranial relapse, postponing WBRT with its potential side effects.
Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability: Results from a laboratory sub-study of the FEISTY trial
Authors: Morrow Gael B. , Feller Timea , McQuilten Zoe , Wake Elizabeth , Ariëns Robert A. S. , Winearls James , Mutch Nicola J. , Laffan Mike A. , Curry Nicola 
Published: September 2022

AbstractBackgroundFibrinogen is the first coagulation protein to reach critical levels during traumatic haemorrhage. This laboratory study compares paired plasma samples pre- and post-fibrinogen replacement from the Fibrinogen Early In Severe Trauma studY (FEISTY; NCT02745041). FEISTY is the first randomised controlled trial to compare the time to administration of cryoprecipitate (cryo) and fibrinogen concentrate (Fg-C; Riastap) in trauma patients. This study will determine differences in clot strength and fibrinolytic stability within individuals and between treatment arms.MethodsClot lysis, plasmin generation, atomic force microscopy and confocal microscopy were utilised to investigate clot strength and structure in FEISTY patient plasma.ResultsFibrinogen concentration was significantly increased post-transfusion in both groups. The rate of plasmin generation was reduced 1.5-fold post-transfusion of cryo but remained unchanged with Fg-C transfusion. Plasminogen activator inhibitor 1 activity and antigen levels and Factor XIII antigen were increased post-treatment with cryo, but not Fg-C. Confocal microscopy analysis of fibrin clots revealed that cryo transfusion restored fibrin structure similar to those observed in control clots. In contrast, clots remained porous with stunted fibres after infusion with Fg-C. Cryo but not Fg-C treatment increased individual fibre toughness and stiffness.ConclusionsIn summary, our data indicate that cryo transfusion restores key fibrinolytic regulators and limits plasmin generation to form stronger clots in an ex vivo laboratory study. This is the first study to investigate differences in clot stability and structure between cryo and Fg-C and demonstrates that the additional factors in cryo allow formation of a stronger and more stable clot.
Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats
Authors: Fahmy Heba M. , Ahmed Mostafa M. , Mohamed Ayman S. , Shams-Eldin Engy , Abd El-Daim Taiseer M. , El-Feky Amena S. , Mustafa Amira B. , Abd Alrahman Mai W. , Mohammed Faten F. , Fathy Mohamed M. 
Published: September 2022

AbstractAimsThe Blood-Brain Barrier (BBB) is a filter for most medications and blocks their passage into the brain. More effective drug delivery strategies are urgently needed to transport medications into the brain. This study investigated the biodistribution of thymoquinone (TQ) and the effect on enzymatic and non-enzymatic oxidative stress indicators in different brain regions, either in free form or incorporated into nanocarriers as mesoporous silica nanoparticles (MSNs). Lipid bilayer-coated MSNs.Materials and methodsMSNs and LB-MSNs were synthesized and characterized using a transmission electron microscope and dynamic light scattering to determine the particle size and zeta potential. TQ encapsulation efficiency and TQ's release profile from LB-MSNs were also examined. The impact of loading LB-MSNs with TQ-on-TQ delivery to different brain areas was examined using chromatographic measurement. Furthermore, nitric oxide, malondialdehyde (MDA), reduced glutathione, and catalase were evaluated as oxidant and antioxidant stress biomarkers.Key findingsThe LB-MSNs formulation successfully transported TQ to several areas of the brain, liver, and kidney, revealing a considerable increase in TQ delivery in the thalamus (81.74%) compared with that in the free TQ group and a considerable reduction in the cortex (−44%). The LB-MSNs formulation had no significant effect on TQ delivery in the cerebellum, striatum, liver, and kidney.SignificanceTQ was redistributed in different brain areas after being encapsulated in LB-MSNs, indicating that LB-MSNs have the potential to be developed as a drug delivery system for selective clinical application of specific brain regions.ConclusionsLB-MSNs are capable nanoplatforms that can be used to target medications precisely to specific brain regions
Chelating agents for diluted geothermal brine reinjection
Authors: Cobos Jacquelin E. , Søgaard Erik G. 
Published: September 2022

Abstract“Blue energy” could be produced by exploiting the large salinity gradient between geothermal fluids and freshwater through a SaltPower system. This study is an attempt to select the most favorable chemicals to avoid injectivity issues when a diluted geothermal fluid resulting from the SaltPower system is returned to the reservoir. Three synthetic chelating agents (oxalic acid, EDTA, and EDDS) and one natural (humic acid) were evaluated through speciation simulations and isothermal titration calorimetry (ITC) experiments. The speciation simulation results indicate that the degree of complexing is highly dependent on pH and chelating agent type. The ITC experiments show that the total heat for the formation of soluble metal–ligand complexes in the rock + geothermal brine system follows: EDTA > EDDS > oxalic acid > humic acid. The simulations and calorimetry results suggest that EDTA could be used to avoid the precipitation of Fe(III) oxides and other minerals (e.g., calcite and dolomite) inside the porous media upon the reinjection of diluted geothermal brine coming from SaltPower electricity production.
Evolutionary morphology of sperm in pholcid spiders (Pholcidae, Synspermiata)
Authors: Dederichs Tim M. , Huber Bernhard A. , Michalik Peter 
Published: September 2022

Abstract
Background
Pholcidae represent one of the largest and most diverse spider families and have been subject to various studies regarding behavior and reproductive biology. In contrast to the solid knowledge on phylogeny and general reproductive morphology, the primary male reproductive system is strongly understudied, as it has been addressed only for few species. Those studies however suggested a high diversity of sperm and seminal secretions across the family. To address this disparity and reconstruct the evolution of sperm traits, we investigate the primary male reproductive system of pholcid spiders by means of light, X-ray, and transmission electron microscopy using a comprehensive taxon sampling with 46 species from 33 genera, representing all five subfamilies.

Results
Our data show a high disparity of sperm morphology and seminal secretions within pholcids. We document several sperm characters that are unique for pholcids, such as a helical band (Pholcinae) or a lamellate posterior centriolar adjunct material (Modisiminae). Character mapping revealed several putative synapomorphies for individual taxa. With regard to sperm transfer forms, we found that synspermia occur only in the subfamily Ninetinae, whereas the other subfamilies have cleistospermia. In several species with cleistospermia, we demonstrate that spermatids remain fused until late stages of spermiogenesis before ultimately separating shortly before the coiling process. Additionally, we explored the previously hypothesized correlation between sperm size and minimum diameter of the spermophor in the male palpal organ. We show that synspermia differ strongly in size whereas cleistospermia are rather uniform, but neither transfer form is positively correlated with the diameter of the spermophor.

Conclusions
Our data revealed a dynamic evolution of sperm characters, with convergences across all subfamilies and a high level of homoplasy. The present diversity can be related to subfamily level and allows for assignments of specific subtypes of spermatozoa. Our observations support the idea that Ninetinae are an ancestral clade within Pholcidae that have retained synspermia and that synspermia represent the ancestral sperm transfer form of Pholcidae.
An analysis of the acquisition of a monetary function by cryptocurrency using a multi-agent simulation model
Authors: Shibano Kyohei , Mogi Gento 
Published: September 2022

AbstractMany types of cryptocurrencies, which predominantly utilize blockchain technology, have emerged worldwide. Several issuers plan to circulate their original cryptocurrencies for monetary use. This study investigates whether issuers can stimulate cryptocurrencies to attain a monetary function. We use a multi-agent model, referred to as the Yasutomi model, which simulates the emergence of money. We analyze two scenarios that may result from the actions taken by the issuer. These scenarios focus on increases in the number of stores that accept cryptocurrency payments and situations whereby the cryptocurrency issuer designs the cryptocurrency to be attractive to people and conducts an airdrop. We find that a cryptocurrency can attain a monetary function in two cases. One such case occurs when 20% of all agents accept the cryptocurrency for payment and 50% of the agents are aware of this fact. The second case occurs when the issuer continuously airdrops a cryptocurrency to a specific person while maintaining the total volume of the cryptocurrency within a range that prevents it from losing its attractiveness.
Improvement in Hurst exponent estimation and its application to financial markets
Authors: Gómez-Águila A. , Trinidad-Segovia J. E. , Sánchez-Granero M. A. 
Published: September 2022

AbstractThis research aims to improve the efficiency in estimating the Hurst exponent in financial time series. A new procedure is developed based on equality in distribution and is applicable to the estimation methods of the Hurst exponent. We show how to use this new procedure with three of the most popular algorithms (generalized Hurst exponet, total triangles area, and fractal dimension) in the literature. Findings show that this new approach improves the accuracy of the original methods, mainly for longer series. The second contribution of this study is that we show how to use this methodology to test whether the series is self-similar, constructing a confidence interval for the Hurst exponent for which the series satisfies this property. Finally, we present an empirical application of this new procedure to stocks of the S &P500 index. Similar to previous contributions, we consider this to be relevant to financial literature, as it helps to avoid inappropriate interpretations of market efficiency that can lead to erroneous decisions not only by market participants but also by policymakers.
Application of the transdisciplinary shipyard energy management framework by employing a fuzzy multiple attribute group decision making technique toward a sustainable shipyard: case study for a Bangladeshi shipyard
Authors: Vakili Seyedvahid , Schönborn Alessandro , Ölçer Aykut I. 
Published: September 2022

AbstractShipbuilding is an energy-intensive industrial sector that produces a significant amount of waste, pollution and air emissions. However, the International Maritime Organization concentrates only on reducing emissions during the operational phase. In order to completely phase out emissions from the shipping industry, a life-cycle approach must be taken. The study implemented the proposed transdisciplinary energy management framework in a Bangladeshi shipyard. The framework aims to support shipyard decision makers in making rational and optimized decisions to make shipyards sustainable, while maintaining good product quality and reducing relative cost. This is achieved by applying the Fuzzy Analytical Hierarchy Process and Fuzzy Order of Preference by Similarity to Ideal Solution methods to identify optimal solutions. In addition to making shipyards more sustainable, the framework can enhance both the business and socio-economic prospects of the shipyard and promote the reputation of the shipyard and improve its competitiveness and, in line with this, lead to the promotion of nationally determined contributions under the Paris Agreement for States. The implementation of the framework shows that the political and legal discipline, the social criteria and the implementation of ISO 14001 and cyber security were the most important criteria and options for the yard's decision makers.
Theoretical exploration of Chinese anthropology and ethnology: the road to construct the Chinese School
Authors: Zhang Jijiao , Wu Yue 
Published: September 2022

AbstractThis paper starts with the four factors that affect Chinese anthropology and ethnology: the Soviet school of ethnology, Marxist ethnology, Western anthropological and ethnological theories, and Chinese experience and theory (government policies and scholar explorations). Based on the influence of foreign theories and the theoretical exploration of local efforts, this paper points out the transformations in Chinese anthropology and ethnology and its research characteristics in different periods. Since the reform and opening up in 1978, Chinese anthropological and ethnological studies have seen the constant expansion of study fields, increasing diversity of study contents, and the introduction of foreign theories and the exploration in Chinese theories in each stage. This shows that China has gradually explored the theoretical research course suitable for its own. The development course and transformations of Chinese anthropological and ethnological theories can be divided into the following three stages: the introduction of foreign theories and reconstruction of Chinese anthropology and ethnology (1978 to 1990), the orientation of Chinese issues and the verification of foreign theories (1990 to 2000), and the establishment of the Chinese School and its increasing international influence (since 2000).
The impact of apraxia and neglect on early rehabilitation outcome after stroke
Authors: Latarnik S. , Stahl J. , Vossel S. , Grefkes C. , Fink G. R. , Weiss P. H. 
Published: September 2022

Abstract
Background
This study aims to characterize the impact of apraxia and visuospatial neglect on stroke patients’ cognitive and functional outcomes during early rehabilitation. Prior work implies an unfavorable effect of visuospatial neglect on rehabilitation; however, previous findings remain ambiguous and primarily considered long-term effects. Even less is known about the impact of apraxia on rehabilitation outcomes. Although clinicians agree on the significance of the first few weeks after stroke for the course of rehabilitation, studies exploring the impact of neglect and apraxia in this early rehabilitation period remain scarce.

Methods
Based on a screening of 515 hospitalized stroke patients from an early rehabilitation ward, 150 stroke patients (75 left-hemispheric strokes, 75 right hemispheric strokes) fulfilled the inclusion criteria and were enrolled in this observational, longitudinal study. The patients’ cognitive and functional statuses were documented at admission to the early rehabilitation ward and discharge. Also, detailed apraxia and neglect assessments were performed at midterm. The predictive values of age and apraxia and neglect severity (as reflected in two components from a principal component analysis of the neglect and apraxia assessments) for cognitive and functional outcomes at discharge were evaluated by multiple regression analyses.

Results
Besides the expected influence of the respective variables at admission, we observed a significant effect of apraxia severity on the cognitive outcome at discharge. Moreover, neglect severity predicted the Early Rehabilitation Barthel Index (Frühreha-Barthel-Index) at discharge. Supplementary moderator analysis revealed a differential effect of neglect severity on the cognitive outcome depending on the affected hemisphere.

Conclusion
Data indicate a strong association between apraxia and visuospatial neglect and early rehabilitation outcomes after stroke.
Viral inactivation by light
Authors: Sadraeian Mohammad , Zhang Le , Aavani Farzaneh , Biazar Esmaeil , Jin Dayong 
Published: September 2022

AbstractNowadays, viral infections are one of the greatest challenges for medical sciences and human society. While antiviral compounds and chemical inactivation remain inadequate, physical approaches based on irradiation provide new potentials for prevention and treatment of viral infections, without the risk of drug resistance and other unwanted side effects. Light across the electromagnetic spectrum can inactivate the virions using ionizing and non-ionizing radiations. This review highlights the anti-viral utility of radiant methods from the aspects of ionizing radiation, including high energy ultraviolet, gamma ray, X-ray, and neutron, and non-ionizing photo-inactivation, including lasers and blue light.
Inter- and intra-limb coordination during initial sprint acceleration
Authors: Donaldson Byron J. , Bezodis Neil E. , Bayne Helen 
Published: September 2022

ABSTRACT
In complex movements, centre of mass translation is achieved through effective joint and segment rotations. Understanding segment organisation and coordination is therefore paramount to understanding technique. This study sought to comprehensively describe inter- and intra-limb coordination and assess step-to-step changes and between-individual variation in coordination during initial sprint acceleration. Twenty-one highly trained to world class male (100 m PB 9.89-11.15 s) and female (100 m PB:11.46-12.14 s) sprinters completed sprint trials of at least 20 m from which sagittal plane kinematics were obtained for the first four steps using inertial measurement units (200 Hz). Thigh-thigh, trunk-shank and shank-foot coordination was assessed using a modified vector coding and segment dominancy approach. Common coordination patterns emerged for all segment couplings across sexes and performance levels, suggesting strong task constraints. Between-individual variation in inter-limb thigh coordination was highest in early flight, while trunk-shank and shank-foot variation was highest in late flight, with a second peak in late stance for the trunk-shank coupling. There were clear step-to-step changes in coordination, with step 1 being distinctly different to subsequent steps. The results demonstrate that inter-limb coordination is primarily anti-phase and trailing leg dominant while ankle motion in flight and late stance appears to be primarily driven by the foot.
Awareness of asthma and its management in primary school teachers in Baghdad, Iraq
Authors: R. M. Salih Muhannad , Y. Abd Arwa , Adnan Fawzi Hayder 
Published: September 2022

Background: Asthma is a major global health issue characterized by chronic airway inflammation. It is linked to a high disease burden and disproportionately high healthcare utilization in severe, uncontrolled cases compared to non-severe asthma. We aimed to conduct this survey among primary school teachers in Baghdad, Iraq, to assess their level of knowledge about asthma and confidence in managing school children with asthma. Methods: This was a cross-sectional study conducted in Baghdad. The study adopted a questionnaire for assessing the asthma knowledge and confidence scores regarding the management of asthmatic children. This questionnaire contained 29-multiple true-false questions based on different aspects, including facts about asthma and the management of asthma by teachers. The questionnaire for testing teachers’ knowledge of asthma and confidence scores regarding the management of asthmatic children was distributed to 150 teachers. Results: The questionnaire was completed by 103 teachers.. Approximately 71% of teachers answered the question ‘What are the three main symptoms of asthma?’ correctly i.e., answering either one symptom (35.9%) or two symptoms (35.9%) correctly. A relatively smaller number of teachers (16.5%) mentioned all three symptoms correctly. Across the 29-multiple true-false questions, more than 75% of teachers answered 11 questions correctly, 50-74% of teachers answered the rest of eight questions appropriately, and <50% of teachers answered the remaining 10 questions properly. The statistical evaluation indicated that the mean total knowledge score about asthma for all the teachers was 20.27 ± 2.97 and the mean total confidence score regarding the management of asthmatic children was 72.44 ± 13.61. Conclusions: This study suggests that teachers from the schools in Baghdad appear to be self-confident in their ability and knowledge to help and manage children with asthma.