bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving behavioural compliance with the COVID-19 precautionary measures by means of innovative communication strategies: Social experimental studies
Authors: van Empelen Pepijn , Preuhs Katharina , Bakker Leonhard A. , Buursma Petra , Andree Rosa , Anraad Charlotte , van Keulen Hilde M. 
Published: July 2022

Objectives
Behavioural measures such as social distancing are crucial to prevent the spread of COVID-19. People sometimes have difficulty to comply with these behavioural measures for various reasons. Insight is needed into evidence-based strategies that can promote compliance. In the present study, we examined whether behaviour change techniques (volitional help sheet (VHS), behavioural journalism (BJ) and empathy inductions (EI)) could promote behavioural compliance with the COVID-19 measures.

Methods
Three online experiments were carried out (N = 424–593) among Dutch adult citizens, using a randomized 2-group post-test and 1-week follow-up design. In each experiment, a control group was compared with the experimental condition (respectively VHS, BJ or EI condition).

Results
Two out of the three different strategies did result in favourable changes with regard to the compliance-related measures. The VHS contributed to changes in perceived susceptibility of others (t = -2,78; f**2 = 0,019), perceived severity (t = -3,65; f**2 = 0,032) and individual behavioural compliance measures. People exposed to the VHS were more likely to receive less visitors (w = 16638; p = 0.003)and avoid crowds (w = 16631; p = 0.003). EI increased the perceived vulnerability of others. Video-based role model stories, based on BJ did not result in any changes.

Conclusions
Behaviour change strategies may contribute to promoting behavioural compliance and could be used in public health communication. The empathy induction can be used to enhance other protection motives, while the volitional help sheet effectively can help people to overcome compliance barriers. Behavioural science can add to fighting the COVID-19 pandemic.
Evaluating the appropriateness of laboratory testing and antimicrobial use in South African children hospitalized for community-acquired infections
Authors: Mapala Lydia , Bekker Adrie , Dramowski Angela 
Published: July 2022

Introduction
Community acquired infection (CAI) is the leading indication for paediatric hospitalization in South Africa.

Methods
We conducted secondary data analysis of prospective, consecutive paediatric admissions to Tygerberg Hospital (May 2015-November 2015). Clinical characteristics, admission diagnosis, appropriateness of diagnostic tests, use of antimicrobial prescriptions, hospital outcome and costs were analyzed.

Results
CAI episodes were documented in (364/451; 81%) children admitted to the general paediatric ward; median age 4.8 months (Interquartile range, IQR, 1.5–17.5) and weight 5.4kg (IQR, 3.6–9.0). Male gender predominated (210/364; 58%), and Human Immunodeficiency Virus infection prevalence was 6.0% (22/364). Common CAI types included respiratory tract infections (197; 54%), gastroenteritis (51; 14%), and bloodstream infections (33; 9%). Pre-hospital antibiotics (ceftriaxone) were given to 152/364 (42%). Of 274 blood cultures and 140 cerebrospinal fluid samples submitted, 5% and 2% respectively yielded a pathogen. Common CAI antibiotic treatment regimens included: ampicillin alone (53%); ampicillin plus gentamicin (25%) and ampicillin plus cefotaxime (20%). Respiratory syncytial virus (RSV) was found in 39% of the children investigated for pneumonia. Most antibiotic prescriptions (323/364; 89%) complied with national guidelines and were appropriately adjusted based on the patient’s clinical condition and laboratory findings. The overall estimated cost of CAI episode management ZAR 22,535 (≈1423 USD) per CAI admission episode. Unfavourable outcomes were uncommon (1% died, 4% required re-admission within 30 days of discharge).

Conclusion
CAI is the most frequent reason for hospitalization and drives antimicrobial use. Improved diagnostic stewardship is needed to prevent inappropriate antimicrobial prescriptions. Clinical outcome of paediatric CAI episodes was generally favourable.
Effect of game-based high-intensity interval training program on the executive function of children with ADHD: Protocol of a randomized controlled trial
Authors: Sun Fenghua , Chow Gary Chi-Ching , Yu Clare Chung-Wah , Ho Ying-Fung , Liu Duo , Wong Stephen Heung-Sang , Siu Parco Ming-Fai , Cooper Simon B. , Jenkins David 
Published: July 2022

Background
Attention-deficit/hyperactivity disorder (ADHD) is a common developmental disorder in childhood, with a 5%-6% worldwide prevalence. Children with ADHD often demonstrate impaired executive function, which is closely related to the development of the commonly observed behavioral problems such as inattention, impaired inhibition, and hyperactivity. The purpose of this study is to examine whether a game-based high-intensity interval training (HIIT) program can improve the executive function of children with ADHD, compared with a traditional structured aerobic exercise program and a non-treatment control group.

Methods/Design
A total of 42 children with ADHD will be recruited to participate in this three-arm school-based randomized controlled trial. An 8-week specially designed game-based HIIT (GameHIIT) program and a traditional game-based structured aerobic exercise (GameSAE) program will be delivered to those children randomly assigned to these two intervention groups, while the children in the control group will maintain their regular physical activity over the same period. A number of outcome measures including executive function, cerebral hemodynamic response, physical activity, physical fitness, and enjoyment and adherence to the intervention will be assessed for both groups at baseline (T0), immediately after the intervention period (T1), and after the follow-up period (T2).

Discussion
HIIT has recently emerged as a feasible and efficacious strategy for increasing physical health outcomes and cognitive function, including executive function, in healthy young people. However, research has yet to investigate whether the executive function of children with ADHD can be effectively enhanced through HIIT. If, as hypothesized, GameHIIT program improves outcomes for children with ADHD, the present research will inform the development of targeted exercise programs that can be more broadly used with this particular population.
Superior reproducibility and repeatability in automated quantitative pupillometry compared to standard manual assessment, and quantitative pupillary response parameters present high reliability in critically ill cardiac patients
Authors: Nyholm Benjamin , Obling Laust , Hassager Christian , Grand Johannes , Møller Jacob , Othman Marwan , Kondziella Daniel , Kjaergaard Jesper 
Published: July 2022

Background
Quantitative pupillometry is part of multimodal neuroprognostication of comatose patients after out-of-hospital cardiac arrest (OHCA). However, the reproducibility, repeatability, and reliability of quantitative pupillometry in this setting have not been investigated.

Methods
In a prospective blinded validation study, we compared manual and quantitative measurements of pupil size. Observer and device variability for all available parameters are expressed as mean difference (bias), limits of agreement (LoA), and reliability expressed as intraclass correlation coefficients (ICC) with a 95% confidence interval.

Results
Fifty-six unique quadrupled sets of measurement derived from 14 sedated and comatose patients (mean age 70±12 years) were included.
For manually measured pupil size, inter-observer bias was -0.14±0.44 mm, LoA of -1.00 to 0.71 mm, and ICC at 0.92 (0.86–0.95). For quantitative pupillometry, we found bias at 0.03±0.17 mm, LoA of -0.31 to 0.36 mm and ICCs at 0.99. Quantitative pupillometry also yielded lower bias and LoA and higher ICC for intra-observer and inter-device measurements.
Correlation between manual and automated pupillometry was better in larger pupils, and quantitative pupillometry had less variability and higher ICC, when assessing small pupils. Further, observers failed to detect 26% of the quantitatively estimated abnormal reactivity with manual assessment.
We found ICC >0.91 for all quantitative pupillary response parameters (except for latency with ICC 0.81–0.91).

Conclusion
Automated quantitative pupillometry has excellent reliability and twice the reproducibility and repeatability than manual pupillometry. This study further presents novel estimates of variability for all quantitative pupillary response parameters with excellent reliability.
Knowledge, attitudes, and behavioral intentions of elderly individuals regarding advance care planning: Questionnaire development and testing
Authors: Cheng Hui-Chuan , Ke Li-Shan , Chang Su-Yu , Huang Hsiu-Ying , Ku Yu-Chen , Lee Ming-Ju 
Published: July 2022

Background
Studies have indicated that the advance care planning knowledge and attitudes of elderly individuals strongly affect their implementation of advance care planning. A measurement with a theoretical base for evaluating elderly individuals’ knowledge, attitudes, and behavioral intentions regarding advance care planning is lacking.

Objectives
To develop a questionnaire and understand elderly individuals’ knowledge, attitudes, and behavioral intentions regarding implementing advance care planning.

Methods
A cross-sectional questionnaire survey was conducted. The content validity index, and statistical methods, including discrimination, factor, and reliability analysis, were adopted for psychometric testing. Descriptive statistics mainly presented data analysis.

Results
401 elderly individuals were recruited from a medical center and one senior activity center. The content validity index was approximately 0.71–0.92 for the developed questionnaires, the Kuder–Richardson formula 20 was 0.84 for advance care planning knowledge, and the Cronbach’s alpha was 0.86, 0.94, 0.76, and 0.92 for attitudes, behavioral intentions, influencing factors, and subjective norms, respectively. The average score for advance care planning knowledge for elderly individuals was 4.42, with a correct answer rate of 49.1%. They lacked knowledge of advance care planning-related legislation. The mean score for attitudes and behavioral intentions was 14.32 and 3.48, respectively. Elderly individuals agreed that advance care planning has benefits but were worried about the emotional distress caused by advance care planning discussions. Elderly individuals with positive behavioral intentions tend to implement advance care planning. Spouses, children, doctors, and nurses are significant reference people for elderly individuals.

Conclusions
The developed questionnaire exhibits good validity and reliability for understanding elderly individuals’ knowledge, attitudes, and behavioral intentions concerning advance care planning. Advance care planning materials or decision aids suitable for elderly individuals must be developed to increase their understanding of advance care planning. Additionally, the role of nurses is indispensable in promoting advance care planning among elderly individuals.
Uniform stabilization for a strongly coupled semilinear/linear system
Authors: Cavalcanti Marcelo M. , Domingos Cavalcanti Valéria N. , Almeida Júnior Dilberto da Silva , Gonzalez Martinez Victor Hugo , Santos Mauro de Lima 
Published: July 2022

Abstract
In this manuscript, we analyze the exponential stability of a strongly coupled semilinear system of Klein-Gordon type, posed in an inhomogeneous medium

Ω

\Omega

, subject to local dampings of different natures distributed around a neighborhood of the boundary according to the geometric control condition (GCC). The first one is of the type viscoelastic and is distributed around a neighborhood

ω

\omega

of the boundary

∂
Ω

\partial \Omega

of

Ω

\Omega

, according to the GCC. The second one is a frictional damping and we consider it hurting the GCC. The third dissipation, which acts only in the second equation (according to the GCC), is of the frictional type. We show that the energy of the system goes uniformly and exponentially to zero for all initial data of finite energy taken in bounded sets of finite energy phase space. We also prove the exponential decay for the linear problem associated with this same system, and in this case, no restrictions are made with respect to dimension of the space nor with respect to the limitation of the initial data in the phase space.
Characterization of damage morphology of structural SiO2 film induced by nanosecond pulsed laser
Authors: Li Yuan , Su Junhong , Xu Junqi , Yang Guoliang 
Published: July 2022

Abstract
We investigated the damage morphology of porous silicon oxide film with a periodic hexagonal hole array irradiated by nanosecond pulsed laser, both experimentally and numerically. To understand the damage morphology, the temperature field distribution and the thermal stress distribution during the laser radiation process were investigated by finite element method. The simulation results show that the thermal stress regulated by periodic structural surface is the reason for the circumferential and discrete distribution of the damage points. The results provide ideas for improving the laser damage resistance of the structural surfaces.
Long-acting paliperidone in Ekbom’s syndrome in Lewy body dementia: A case report
Authors: Orsolini Laura , Corona Diana , Salvi Virginio , Volpe Umberto 
Published: July 2022

Abstract

Introduction
Ekbom Syndrome (ES) is characterised by fixed, delusional beliefs that one’s body is infested by parasites or other vermin in absence of supporting clinical evidence. Antipsychotic (AP) treatment, including long-acting injectable (LAI) AP in subjects with poor compliance, is prescribed to manage behavioural and psychotic symptomatology.

Objectives
We describe a 70-year-old woman who was hospitalised after experiencing new-onset delusions of infestation with visual and tactile hallucinations that led to bizarre behaviours and progressive social withdrawal.

Methods
She was diagnosed with ES and was initially treated with risperidone 3 mg; however, due to poor compliance and a lack of insight, she was switched to LAI palmitate paliperidone (LAI-PP). She was followed up for 8 months, administering Positive and Negative Syndrome Scale, Montreal Cognitive Assessment, Global Assessment of Functioning, Brief Psychiatric Rating Scale, neurocognitive assessment, and neuroimaging.

Results
After a progressive cognitive deterioration, she was diagnosed with an ES secondary to Lewy body dementia (DLB).

Conclusion
The LAI-PP treatment determined a complete clinical remission of psychotic symptoms despite the emergence of an iatrogenic akinetic-rigid syndrome. The delay of confirmatory neurological diagnosis, the associated risky behaviours of the patient, and poor treatment adherence led clinicians to prescribe LAI-PP following a good clinical response to oral paliperidone. However, in the case of a suspected DLB diagnosis, the prescription of an LAI-PP as a first-line strategy should be carefully evaluated.
Paroxetine Increases δ Opioid Responsiveness in Sensory Neurons
Authors: Brackley Allison Doyle , Jeske Nathaniel A. 
Published: July 2022

AbstractThere are currently no Food and Drug Administration (FDA)-approved δ-opioid receptor (DOR)-selective agonists, despite having fewer side effects in rodents and nonhuman primates compared with traditional μ-opioid receptor (MOR) therapeutics (Vanderah, 2010). Targeting peripheral receptors is an attractive strategy to reduce abuse potential. However, peripheral opioid receptors do not readily respond to agonists unless primed by inflammation, which would limit their efficacy in noninflammatory pain patients (Stein et al., 1989). It was recently identified that G-protein-coupled receptor kinase 2 (GRK2) maintains DOR incompetence in noninflamed nociceptors (Brackley et al., 2016, 2017). Here, we report that paroxetine, a selective serotonin reuptake inhibitor (SSRI) and potent GRK2 inhibitor (Thal et al., 2012), reduces chronic GRK2 association with membrane DOR, thereby enhancing peripheral DOR-mediated analgesic competence in the absence of inflammation. Interestingly, paroxetine’s effects on GRK2in vivoare limited to peripheral tissues in the male rat. The effects of paroxetine on DOR competence are notably antagonized by GRK2 overexpression. This is the first study to suggest that paroxetine induces peripheral DOR analgesic competence through a GRK2-dependent mechanism, improving analgesic efficacy in noninflamed tissue. Because paroxetine targets the protein that governs peripheral opioid receptor responsiveness, and does so in the absence of inflammation, we propose that paroxetine may be suitable as a co-therapy with peripherally-restrictive doses of opioids to improve analgesic efficacy in noninflammatory pain conditions.
Network States Classification based on Local Field Potential Recordings in the Awake Mouse Neocortex
Authors: Zerlaut Yann , Zucca Stefano , Fellin Tommaso , Panzeri Stefano 
Published: July 2022

AbstractRecent studies using intracellular recordings in awake behaving mice revealed that cortical network states, defined based on membrane potential features, modulate sensory responses and perceptual outcomes. Single-cell intracellular recordings are difficult and have low yield compared to extracellular recordings of population signals, such as local field potentials (LFPs). However, it is currently unclear how to identify these behaviorally-relevant network states from the LFP. We used simultaneous LFP and intracellular recordings in the somatosensory cortex of awake mice to design a network state classification from the LFP, the Network State Index (NSI). We used the NSI to analyze the relationship between single-cell (intracellular) and population (LFP) signals over different network states of wakefulness. We found that graded levels of population signal faithfully predicted the levels of single-cell depolarization in nonrhythmic regimes whereas, in δ ([2–4 Hz]) oscillatory regimes, the graded levels of rhythmicity in the LFP mapped into a stereotypical oscillatory pattern of membrane potential. Finally, we showed that the variability of network states, beyond the occurrence of slow oscillatory activity, critically shaped the average correlations between single-cell and population signals. Application of the LFP-based NSI to mouse visual cortex data showed that this index increased with pupil size and during locomotion and had a U-shaped dependence on population firing rates. NSI-based characterization provides a ready-to-use tool to understand from LFP recordings how the modulation of local network dynamics shapes the flexibility of sensory processing during behavior.
Effect of estradiol and IGF1 on glycogen synthesis in bovine uterine epithelial cells
Authors: Gonzalez Alexis , Berg Malia D , Southey Bruce , Dean Matthew 
Published: July 2022

In brief
Glucose is an important nutrient for the endometrium and embryo during pregnancy. This study shows that estradiol (E2)/IGF1 signaling stimulates glycogen synthesis in the uterine epithelium of cows, which could provide glucose when needed.

Abstract
Glycogen storage in the uterine epithelium peaks near estrus and is a potential source of glucose for the endometrium and embryos. However, the hormonal regulation of glycogen synthesis in the uterine epithelium is poorly understood. Our objective was to evaluate the effect of E2 and insulin-like growth factor 1 (IGF1) on glycogenesis in immortalized bovine uterine epithelial (BUTE) cells. Treatment of BUTE cells with E2 (0.1–10 nM) did not increase glycogen levels. However, treatment of BUTE cells with IGF1 (50 or 100 ng/mL) resulted in a >2-fold increase in glycogen. To determine if the uterine stroma produced IGF1 in response to E2, bovine uterine fibroblasts were treated with E2, which increased IGF1 levels. Immunohistochemistry showed higher levels of IGF1 in the stroma on day 1 than on day 11, which coincides with higher glycogen levels in the uterine epithelium. Western blots revealed that IGF1 treatment increased the levels of phospho-AKT, phospho-GSKβ, hexokinase 1, and glycogen synthase in BUTE cells. Metabolomic (GC-MS) analysis showed that IGF1 increased 3-phosphoglycerate and lactate, potentially indicative of increased flux through glycolysis. We also found higher levels of N-acetyl-glucosamine and protein glycosylation after IGF1 treatment, indicating increased hexosamine biosynthetic pathway activity. In conclusion, IGF1 is produced by uterine fibroblasts due to E2, and IGF1 increases glucose metabolism and glycogenesis in uterine epithelial cells. Glycogen stored in the uterine epithelium due to E2/IGF1 signaling at estrus could provide glucose to the endometrium or be secreted into the uterine lumen as a component of histotroph.
Identifying Arrhythmias Based on ECG Classification Using Enhanced-PCA and Enhanced-SVM Methods
Authors: Philip Akhil Mathew , Hemalatha Dr. S 
Published: July 2022

The "Cardio Vascular Diseases (CVDs)" had already attained worrisome proportions in both advanced and emerging nations in recent times. Physically inactive behaviors, altered eating, and occupational routines, and reduced daily fitness were all recognized as crucial contextual elements, in addition to genetics. Considering CVDs have such a significant morbidity and mortality, accurate and early diagnosis of cardiac disease by "ElectroCardioGram (ECG)" allows clinicians to decide suitable therapy for a multitude of cardiovascular disorders. The interpretation of ECG signal is an important bio-signal processing area that involves the application of computer science and engineering to detect and visualize the functional status of the heart. Therefore, in the present work, a detailed study on ECG signals denoising and abnormalities detection using different techniques were performed. Annoying distortions and noisy particles are common in ECG signals. The "Biased Finite Impulse Response (BFIR)" preprocessing filtering is employed in this research to eliminate the noises in the raw ECG signals. The "Nonlinear-Hamilton" segmentation method is employed to segment the 'R' peak signals. To decrease the extraneous features included in the segmented ECG data, the innovative "Enhanced Principal Component Analysis (EPCA)" was applied for feature extraction. A unique "Enhanced version of the Support Vector Machine (ESVM)" framework with a "Weighting Kernel" based technique is proposed for classifying the ECG data. The 'Q', 'R', and 'S' waves in the given ECG data will be identified by this framework, allowing it to characterize the cardiac rhythm. The evaluation metrics of the EPCA-ESVM proposed method is comparatively analyzed with our previous approach EPSO. To estimate the results for the dataset from MIT-BIH it was experimented with by the EPSO and the EPCA-ESVM methods focused upon different parameters such as Accuracy, F1-score, etc. The final findings of the EPCA-ESVM method were good than the EPSO method in which the accuracy is higher even though unbalanced data were present.