bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wastesites.io: Mapping Solid Waste to Meet Sustainable Development Goals
Authors: Blevins Chad , Karanja Elijah , Omojah Sharon , Chishala Chomba , Oniosun Temidayo Isaiah 
Published: November 2022

AbstractThe World Bank has conservatively estimated that 33% of global waste is managed in an environmentally unsafe way (Kaza et al. 2018). Waste generation could nearly double by 2050 with generation per capita expected to increase by 40% in low- and middle-income countries, many of which are growing at an unsustainable pace with limited resources dedicated to waste management. YouthMappers creating local geospatial data about sites of illegal trash dumping can play a key role in mitigating impacts and improving waste management, and in turn, impact public health. Several of the UN SDGs are supported by creating and sustaining a clean, healthy environment, particularly in this case, SDG 12 Responsible Consumption and Production and ultimately, SDG 3 Health. A novel tool, Wastesites.io, has been initiated to leverage youth action and connectivity of YouthMappers in order to solve these challenges together.
Mapping for Resilience: Extreme Heat Deaths and Mobile Homes in Arizona
Authors: Charley Elisha , Varfalameyeva Katsiaryna , Alsanad Abdulrahman , Solís Patricia 
Published: November 2022

AbstractYouthMappers help discover hidden vulnerabilities to extreme heat in the face of a changing climate by mapping health outcomes compared to energy assistance. What emerged is a pattern of disproportionate deaths by housing type, necessitating innovations in tagging unique mobile home attributes in OpenStreetMap (OSM). The resulting community engagement generated solutions that stakeholders and residents of mobile homes can implement for greater resilience, and a model for connecting SDG 13 (Sustainable Development Goals) for climate action to SDG 3 good health and well-being by looking at the homes where people live.
Reflecting on the YouthMappers Movement
Authors: Anderson Jennings , Blevins Chad , Cowan Nuala , Carney-Nedelman Dara , Clark Courtney , Crino Michael , Engstrom Ryan , Hinton Richard , Mann Michael , McCusker Brent , Nealon Rory , Solís Patricia , Zeballos Marcela 
Published: November 2022

AbstractYouthMappers co-founders and organizers reflect on the contributions narrated in this volume, and in a larger sense, the contributions of the more than 300 university campus chapters in more than 60 countries. These reflections provide a point of departure to imagine what’s next and “where to go from here.” We call for greater investment in youth, especially in majoritarian countries, as these contributions represent the dividend of previous investment in local capacity for the SDGs.
Molecular Imaging of the Human Emotion Circuit
Authors: Nummenmaa Lauri , Seppälä Kerttu , Putkinen Vesa 
Published: November 2022

AbstractEmotions modulate behavioral priorities via central and peripheral nervous systems. Understanding emotions from the perspective of specific neurotransmitter systems is critical, because of the central role of affect in multiple psychopathologies and the role of specific neuroreceptor systems as corresponding drug targets. Here, we provide an integrative overview of molecular imaging studies that have targeted the human emotion circuit at the level of specific neuroreceptors and transmitters. We focus specifically on opioid, dopamine, and serotonin systems, given their key role in modulating motivation and emotions, and discuss how they contribute to both healthy and pathological emotions.
Clinical Neuroscience Meets Second-Person Neuropsychiatry
Authors: Schilbach Leonhard , Lahnakoski Juha M. 
Published: November 2022

AbstractDisturbances of social and affective processes are at the core of psychiatric disorders. Together with genetic predisposing factors, deprivation of social contact and dysfunctional relationships during development are some of the most important contributors to psychiatric disorders over the lifetime, while some developmental disorders manifest as aberrant social behavior early in life. That the cause of mental illness is rooted in the brain was long held as a truism, yet finding the causes for and neurobiological correlates of these conditions in the brain has proven and continues to be difficult (Venkatasubramanian G, Keshavan MS, Ann Neurosci 23:3–5. https://doi.org/10.1159/000443549, 2016). In clinical practice, psychiatric disorders are diagnosed based on categorical manuals, such as the DSM and ICD, which form a useful guide for clinical diagnosis and interventions. Yet, understanding the specific neural mechanisms leading to or characterizing distinct psychiatric conditions through this categorical approach has been slow (see, for example, Lynch CJ, Gunning FM, Liston C, Biol Psychiatry 88:83–94. https://doi.org/10.1016/j.biopsych.2020.01.012, 2020). Findings in the brain often do not seem to lend support to common mechanisms for the defined disorder categories. This is not particularly surprising because, in these diagnostic manuals, multiple combinations of symptoms can often lead to the same diagnosis, which is reflected in highly variable phenotypes of psychiatric disorders.
The Time Has Come to Be Mindwanderful: Mind Wandering and the Intuitive Psychology Mode
Authors: Gonçalves Óscar F. , da Silva Mariana Rachel Dias 
Published: November 2022

AbstractNo matter how hard you try—pinching different parts of your body, slapping your face, or moving restlessly in your seat—you cannot prevent your mind from occasionally escaping from the present experience as you enter into a mental navigation mode. Sometimes spontaneously, others deliberately, your mind may move to a different time—you may see yourself running an experiment inspired by the chapter you just finished reading or you may imagine yourself on a quantum leap into the future as you fantasize about the delivery of your Nobel Prize acceptance speech. Your mind may move to a distinct space, for example, as you replay last weekend’s party or anticipate a most desirable date, and may even venture into the mind of another (e.g., as you embody the mind of the author you are currently reading). Our minds can accomplish all this mental navigation in fractions of a second, allowing us to see ourselves or even impersonate different people across space and time. While teleportation and time travel may never be physically possible, our wandering minds are indeed very accomplished “time machines” (Suddendorf T, Corballis MC, Behav Brain Sci 30(3), 2007).
Calcification of the visceral aorta and celiac trunk is associated with renal and allograft outcomes after deceased donor liver transplantation
Authors: Siepmann Robert , Bruners Philipp , Lang Sven Arke , Bednarsch Jan , Amygdalos Iakovos , Joechle Katharina , Pedersoli Federico , Keil Sebastian , Isfort Peter , Ulmer Tom Florian , Kuhl Christiane , Neumann Ulf Peter , Meister Franziska Alexandra , Czigany Zoltan 
Published: November 2022

Abstract
Purpose
Atherosclerosis affects clinical outcomes in the setting of major surgery. Here we aimed to investigate the prognostic role of visceral aortic (VAC), extended visceral aortic (VAC+), and celiac artery calcification (CAC) in the assessment of short- and long-term outcomes following deceased donor orthotopic liver transplantation (OLT) in a western European cohort.

Methods
We retrospectively analyzed the data of 281 consecutive recipients who underwent OLT at a German university medical center (05/2010–03/2020). The parameters VAC, VAC+, or CAC were evaluated by preoperative computed tomography-based calcium quantification according to the Agatston score.

Results
Significant VAC or CAC were associated with impaired postoperative renal function (p = 0.0016; p = 0.0211). Patients with VAC suffered more frequently from early allograft dysfunction (EAD) (38 vs 26%, p = 0.031), while CAC was associated with higher estimated procedural costs (p = 0.049). In the multivariate logistic regression analysis, VAC was identified as an independent predictor of EAD (2.387 OR, 1.290–4.418 CI, p = 0.006). Concerning long-term graft and patient survival, no significant difference was found, even though patients with calcification showed a tendency towards lower 5-year survival compared to those without (VAC: 65 vs 73%, p = 0.217; CAC: 52 vs 72%, p = 0.105). VAC+ failed to provide an additional prognostic value compared to VAC.

Conclusion
This is the first clinical report to show the prognostic role of VAC/CAC in the setting of deceased donor OLT with a particular value in the perioperative phase. Further studies are warranted to validate these findings.

Graphical abstract

CT computed tomography, OLT orthotopic liver transplantation
Treatment options for unresectable hepatocellular carcinoma with hepatitis virus infection following sorafenib failure
Authors: Li Xiaomi , Ding Xiaoyan , Li Wei , Chen Jinglong 
Published: November 2022

Abstract
Background
Currently, there are a few treatment options for unresectable hepatocellular carcinoma (HCC) after progression following sorafenib (SOR) therapy, but with limited benefit. The purpose of this study was to investigate the efficacy and safety of tyrosine kinase inhibitors (TKIs) combined with immune checkpoint inhibitors (ICIs) as second-line treatment.

Methods
From May 2018 to May 2021, a total of 93 HCCs who failed SOR treatment were included in this study and divided into TKI group (n = 37) and TKI-ICI group (n = 56). Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR) and safety were estimated among the two groups. In addition, univariate and multivariate Cox regression analyses were performed for OS and PFS to identify possible prognostic factors.

Results
With a median follow-up time of 13.7 months, the median age of patients was 56 (range, 50–64) years and most were male. All of the patients were hepatitis virus-related HCC. Both median OS (7.63 months vs 19.23 months, P < 0.001) and median PFS (2.97 months vs 8.63 months, P < 0.001) were significantly improved in the TKI-ICI group compared to the TKI group. A significant increase in DCR was demonstrated in the TKI-ICI group compared to the TKI group (83.9% vs 45.9%, P = 0.0003), although no significant difference in ORR was reported (21.4% vs 8.1%, P = 0.1552). Multivariate Cox regression analysis of OS and PFS revealed that second-line regimen was an independent protective factor affecting death and progression in HCCs after SOR failure. In addition, Child–Pugh B7 was an independent risk factor of OS. Finally, there was no significant difference in the incidence of any grade or grade 3/4 adverse events (AEs) between the two groups, and no treatment-related deaths were observed.

Conclusion
This real-world study suggests that the combination of TKIs and ICIs benefits more than mono-TKIs and is well tolerated in HCCs with hepatitis virus infection after SOR failure.
Nonlinear pricing, biased consumers, and regulatory policy
Authors: Ho Phuong 
Published: November 2022

AbstractRecent empirical analyses show consumers in electricity and water markets respond to average price rather than marginal price, calling for information provision policies that help correct the consumers’ bias. This paper characterizes the regulated tariff if the regulator is informed about the average-price response of consumers. I find the regulated tariff for biased consumers promotes equity gains by featuring quantity premia and providing access to utility consumption for a larger population than in the world of rational consumers. The world of biased consumers can also yield higher total welfare. These results bring up the opportunity costs of the information provision programs that help consumers correct the bias.
Bond strength between temporary 3D printable resin and conventional resin composite: influence of cleaning methods and air-abrasion parameters
Authors: Lankes Valerie , Reymus Marcel , Liebermann Anja , Stawarczyk Bogna 
Published: November 2022

Abstract
Objectives
The influence of different cleaning methods, air-abrasion parameters, and aging on shear bond strength (SBS) and tensile bond strength (TBS) of 3D resin luted to composite resin.

Materials and methods
Nine hundred resin substrates were 3D printed (D20II, Rapid Shape) and cleaned with either isopropanol (ISO), butyldiglycol-based solution (BUT), or centrifugation (CEN). After 24-h storage in 37 °C water, specimens were air-abraded (mean particle size 50 µm; n = 60) with either alumina at 0.1 MPa (AL0.1) or 0.4 MPa (AL0.4) and glass pearls at 0.1 MPa (GP0.1) and 0.4 MPa (GP0.4) or conditioned with visio.link (control) and luted with PanaviaV5. Initially (24 h, 37 °C water storage) or after aging (10,000 thermal cycles), SBS and TBS were measured, and fracture types were examined. Surface free energy (SFE) and roughness (Ra) were determined after air-abrasion. Kolmogorov–Smirnov, Kruskal–Wallis H, Mann–Whitney U, chi-square, and partial eta-squared were computed.

Results
SBS measurements presented higher values than TBS (p < 0.001–0.033). Within the pretreatment groups, CEN showed the highest SBS and TBS values compared to cleaning with ISO or BUT (p < 0.001–0.040). Pretreatment with GP0.1 displayed the lowest bond strength values (p < 0.001–0.049), and mostly adhesive fractures occurred. The highest Ra values (p < 0.001) were observed for AL0.4 pretreatment.

Conclusions
Pretreatment with AL0.4 and the control group mainly presented the highest bond strength values. Thermocycling had a positive effect on the bond strength.

Clinical relevance
According to this study, 3D-printed restorations should be pretreated with AL0.4 or with visio.link before adhesive luting, regardless of their cleaning.
A method for digital business ecosystem design: situational method engineering in an action research project
Authors: Tsai Chen Hsi , Zdravkovic Jelena , Söder Fredrik 
Published: November 2022

AbstractDigital business ecosystem (DBE) is a paradigm that enables developing and monitoring novel business models of collaborating organisations and individuals using ICT as the foundation. Different from traditional online networked models such as manufacturer, retailer, or franchise centred, using a shared digital environment, DBE fosters heterogeneity, symbiosis, coevolution, and self-organisation of its multiple actors, which enables it to span different business domains as well as exhibits diverse interests. For many organisations and individuals, DBE presents a new collaborative approach to leverage offered and desired resources among the involved members to meet each of their goals. As such, it is foreseen to be of high value to the involved actors, but at the same time, it is often complex due to many correlated interactions of these actors and thus difficult to design and manage. Furthermore, the current state of the art shows a lack of methodological guidance for DBE design. We propose a method for DBE design that follows the requirements collected from industry experts and practitioners by applying situational method engineering to enable its modularised design. The method for design is validated by action research in the setting of Digital Vaccine, a Swedish DBE managing health-related services.
First Report on Colletotrichum sansevieriae Causing Anthracnose of Sansevieria trifasciata in Germany
Authors: Brand Thomas , Wichura Alexandra 
Published: November 2022

AbstractSansevieria species are valued in Europe as potted houseplants because of their modest maintenance requirements and low susceptibility to diseases and pests. Water-soaked leaf spots that eventually coalesced into large, drying lesions were observed on Sansevieria trifasciata freshly imported from Costa Rica. A Colletotrichum was isolated from the fungal fruiting bodies that developed on these necroses. It was confidently determined to be C. sansevieriae based on the host plant and microbiological as well as molecular biology test results. This is the first detection of C. sansevieriae in Germany.
Significance of C-reactive protein in patients with chronic myelomonocytic leukemia
Authors: Liang-Fonseca Jian , Geissler Klaus 
Published: November 2022

SummaryIn a retrospective study, we analyzed the prevalence of elevated C‑reactive protein (CRP) serum levels in 148 patients with chronic myelomonocytic leukemia (CMML), their potential prognostic impact, and potential correlations with laboratory features. Normal, up to 10-fold, and more than 10-fold elevated CRP levels were found in 18%, 59%, and 23% of CMML patients, respectively. Using the CRP cutoff value of 10 mg/L of the widely used Glasgow score, high CRP values were associated with inferior survival (13 vs. 39 months, p = 0.014), which retained prognostic significance in multivariate analysis. High CRP values were associated with lower hemoglobin levels. The survival difference between patients with normal (< 5 mg/L) and elevated CRP levels persisted after exclusion of patients with clinical infection. These findings indicate that in CMML patients, the presence of an acute-phase reaction is associated with a poor outcome, independent of clinical infection.
Correlation between OCT-angiography and photopic negative response in patients with primary open angle glaucoma
Authors: Tabl Ahmed Abdelshafy , Tabl Marwa Abdelshafy 
Published: November 2022

Abstract
Purpose
To evaluate the association between OCT-angiography (OCTA) and photopic negative response (PhNR) in open angle glaucoma (OAG) patients and assess the diagnostic accuracy of these parameters in early detection of glaucoma.

Methods
A total of 152 eyes were enrolled in this study, 28 eyes with mild POAG (group I), 44 eyes with moderate-severe POAG (group 2) & 80 eyes of healthy subjects (control group). Full ophthalmological examination, OCTA and PhNR measurements were underwent for all participants. RNFL, GCC thicknesses, PhNR (implicit time and amplitude) were recorded. The superficial and deep capillary plexus vessel density (SCP-VD%, DCP-VD%) were measured by using 6 × 6 mm macula OCTA scans. The peripapillary vessel density (RPC-VD %) were measured by using 4.5 × 4.5 mm optic disk head OCTA scans.

Results
There were reduction of the median Interquartile range (IQR) thickness of the GCC and RNFL in OAG eyes versus normal (P < 0.001). RPC-VD%, SCP-VD % and DCP-VD% were significantly reduced in OAG eyes versus normal (P < 0.001). Increased OAG severity was associated with more reduction in PhNR amplitude and increased implicit time. Reduced PhNR amplitude and prolonged latency were significantly correlated with reduced vascular parameters. The RCP-VD and PhNR amplitude demonstrated higher diagnostic accuracy (98.7) with the largest AUC and higher sensitivity and specificity (100% & 98.7%, respectively), followed by the PhNR implicit time with (AUC = 0.995) with a diagnostic accuracy 98.7. The SCP-VD, RNFL and GCC thickness had a diagnostic accuracy of (75.0, 81.6 & 84.2), respectively (P < 0.001).

Conclusions
OCTA vascular parameters displayed significant positive correlation with PhNR amplitude and significant negative correlation with PhNR implicit time. OCTA and PhNR parameters showed a high diagnostic accuracy for detection of glaucoma, and both may provide promising insight in early detection of glaucoma.
This study was retrospectively registered on ClinicalTrials.gov (identifier, NCT05104294).
Delayed inputs of hot 137Cs and 241Am particles from Chernobyl to sediments from three Finnish lakes: implications for sediment dating
Authors: Appleby Peter G. , Piliposyan Gor , Weckström Jan , Piliposian Gayane 
Published: November 2022

AbstractAnomalous peaks in the 137Cs and 241Am records from three lake sediment cores from southern Finland appear to be due to the presence of micron-size hot radioactive particles, almost certainly originating in fallout from the 1986 Chernobyl accident. Since the imbedding sediments all post-date 1986 by several decades, it appears that they were initially deposited on the catchments of these lakes and transported to the lakes some years later. The activities of the particles were determined using a sequential splitting process. Two of the particles were found to contain 137Cs with activities of 64 ± 4 mBq and 266 ± 15 mBq respectively. The third contained 241Am with an activity of 17 ± 2 mBq, but no evidence of significant amounts of 137Cs. The delayed input of such particles into the sedimentary records highlights the need for care in using 137Cs or 241Am as chronostratigraphic markers in areas subject to significant levels of contamination from Chernobyl fallout.
(−)-Guaiol triggers immunogenic cell death and inhibits tumor growth in non-small cell lung cancer
Authors: Yang Xiaohui , Yang Junling , Gu Xiaoxia , Tao Yuhua , Ji Hongjuan , Miao Xian , Shen Shuijie , Zang Haiyang 
Published: November 2022

Abstract(−)-Guaiol is a sesquiterpenoid found in many traditional Chinese medicines with potent antitumor activity. However, its therapeutic effect and mechanism in non-small cell lung cancer (NSCLC) have not been fully elucidated. In this study, (−)-Guaiol was found to induce immunogenic cell death (ICD) in NSCLC in vitro. Using (−)-Guaiol in vivo, we found that (−)-Guaiol could suppress tumor growth, increase dendritic cell activation, and enhance T-cell infiltration. Vaccination experiments suggest that cellular immunoprophylaxis after (−)-Guaiol intervention can suppress tumor growth. Previous studies have found that (−)-Guaiol induces apoptosis and autophagy in NSCLC. Apoptosis and autophagy are closely related to ICD. To explore whether autophagy and apoptosis are involved in (−)-Guaiol-induced ICD, we used inhibitors of apoptosis and autophagy. The results showed that the release of damage-associated molecular patterns (DAMPs) was partly reversed after inhibition of apoptosis and autophagy. In conclusion, these results suggested that the (−)-Guaiol triggers immunogenic cell death and inhibits tumor growth in NSCLC.
An efficient hybrid stock trend prediction system during COVID-19 pandemic based on stacked-LSTM and news sentiment analysis
Authors: Sharaf Marwa , Hemdan Ezz El-Din , El-Sayed Ayman , El-Bahnasawy Nirmeen A. 
Published: November 2022

AbstractThe coronavirus is an irresistible virus that generally influences the respiratory framework. It has an effective impact on the global economy specifically, on the financial movement of stock markets. Recently, an accurate stock market prediction has been of great interest to investors. A sudden change in the stock movement due to COVID -19 appearance causes some problems for investors. From this point, we propose an efficient system that applies sentiment analysis of COVID-19 news and articles to extract the final impact of COVID-19 on the financial stock market. In this paper, we propose a stock market prediction system that extracts the stock movement with the COVID spread. It is important to predict the effect of these diseases on the economy to be ready for any disease change and protect our economy. In this paper, we apply sentimental analysis to stock news headlines to predict the daily future trend of stock in the COVID-19 period. Also, we use machine learning classifiers to predict the final impact of COVID-19 on some stocks such as TSLA, AMZ, and GOOG stock. For improving the performance and quality of future trend predictions, feature selection and spam tweet reduction are performed on the data sets. Finally, our proposed system is a hybrid system that applies text mining on social media data mining on the historical stock dataset to improve the whole prediction performance. The proposed system predicts stock movement for TSLA, AMZ, and GOOG with average prediction accuracy of 90%, 91.6%, and 92.3% respectively.