bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurses’ lived experiences in the utilization of standardized nursing languages in documentation of nursing care, in Cross River State, Nigeria
Authors: Enebeli Emmanuel Chukwunwike , Akpan‐Idiok Paulina Ackley , Chukwudozie Chioma Chidiebere 
Published: October 2022

AbstractPurposeThe concept of standardized nursing languages (SNLs) was introduced to solve the problem created by the use of different terminologies to document care by nurses working in diversified contexts. This study explored professional nurses’ experiences in the utilization of SNL in documenting patients’ care.MethodsA qualitative descriptive design was adopted for this study, and a purposive sampling technique was used to select eight nurses for the study from a tertiary health facility. Data were collected using an in‐depth interview guide. Rigour and trustworthiness were ensured using the techniques of credibility, dependability, transferability, and confirmability. Data were analyzed according to Braun and Clarke's six‐step thematic analyses.FindingsThe key finding indicates that nurses appreciate the advantages of utilizing SNLs; however, they encounter some problems in formulating correct nursing diagnoses and several challenges in using SNLs, such as manpower shortage, lack of time, inappropriate materials, inadequate knowledge of NOC and NIC. These challenges have caused the utilization of SNLs among nurses to be poor.ConclusionsSNLs have been recognized as the gold standard for nursing practice; however, their usage is poor. To ensure the adequate use of SNLs, it is the responsibility of the nurse and the institution to resolve the barriers to the use of SNLs. The study recommends that the utilization of SNLS could be improved with the provision of more seminars, the creation of a policy on SNLs use, and the use of electronic documentationImplication to nursingThis study contributes by providing a picture of nurses’ experiences in utilizing SNLs in Nigeria, identifying challenges experienced and recommending ways to tackle these challenges.
Getting the message out: Information and communication technologies and agricultural extension
Authors: Giulivi Nicoletta , Harou Aurélie P. , Gautam Shriniwas , Guereña Davíd 
Published: October 2022

AbstractThere has been much optimism about the potential of information and communication technologies (ICTs) to provide agricultural extension services to remote households. Yet, little is known about how different communication methods fare, and, moreover, whether different segments of the population adopt information communicated via different means equally. We conduct a randomized controlled trial comparing the effectiveness of three ICTs—radio, voice response messages, and a smartphone app—with traditional extension training in communicating fertilizer management practices across four districts in rural Nepal. We find that farmers in the smartphone app and the extension training programs are on average 8.4 and 13 percentage points more likely to adopt top dressing fertilizer practices compared to control farmers, statistically significant at the 1% and 5% levels, respectively. Farmers in the smartphone app treatment achieve the highest agronomic literacy test scores, 7.8 percentage points higher than the control, statistically significant at the 1% level. In contrast, farmers receiving radio or voice response messages were not more likely to adopt the same fertilizer recommendations nor show improved specific or general agronomic knowledge relative to control farmers. Our results suggest that smartphone apps are more cost effective at inducing farmer knowledge and technology adoption than extension trainings. Heterogeneous treatment effects, however, reveal that a targeted ICT approach may be more effective in disseminating extension advice.
Traditional Chinese Medicine: An Effective Way of Treating Cancer
Authors: Chen Ling , Shen Shihao 
Published: October 2022

AbstractThe incidence of cancer in the world has been rising in recent years. Although Western medicine has the ability to treat tumors, some Western cancer treatments cause serious and even irreversible damage to the body. Traditional Chinese medicine (TCM) combines the excellence of Chinese philosophy and the cumulative knowledge of thousands of years of clinical practice. TCM has incomparable advantages in the prevention and treatment of tumors. This review summarizes the epidemiological data of tumors and focuses on the pathogenesis theory of tumors. It demonstrates the advantages and shortcomings of TCM in tumor prevention and treatment. Based on our clinical experience, we put forward an optimization plan of TCM treatments of tumors and a plan for the propagation of TCM culture, which we believe will help TCM become more recognized in international medicine.
Growing Chinese Medicinal Herbs to Prevent and Treat Chronic Illness
Authors: Giblette Jean 
Published: October 2022

AbstractChronic illnesses, such as cancer, heart disease, and diabetes, are on the rise throughout the world due to modern diets and other factors. Western medicine has been ineffective in preventing or treating them. Thus, members of the public have sought alternatives. In the past 50 years, two social movements in the United States have shared an understanding of health in relation to the natural world. Chinese herbal medicine and practitioners of ecological agriculture agree that the nutritional requirements of complex living organisms are interconnected. Empirical findings in these applied sciences are supported by recent discoveries. However, economic constraints inhibit development. Each field is described separately, with notes from the author’s direct experience.
Complete meiosis in rat prepubertal testicular tissue under in vitro sequential culture conditions
Authors: Saulnier Justine , Soirey Mathilde , Kébir Nasreddine , Delessard Marion , Rives‐Feraille Aurélie , Moutard Laura , Dumont Ludovic , Rives Nathalie , Rondanino Christine 
Published: October 2022

AbstractBackgroundTesticular tissue cryopreservation before gonadotoxic treatments allows fertility preservation in children suffering from cancer. Fertility restoration strategies, in particular in vitro maturation of prepubertal testicular tissue, are being developed mainly in animal models. The rat, widely used in biomedical research, including in reproductive biology, is a relevant model.ObjectivesTo determine whether sequential two‐step culture protocols can improve the efficiency of rat in vitro spermatogenesis.Materials and methodsRat prepubertal testicular tissues were cultured on agarose gels with either a one‐step or two‐step protocol with or without polydimethylsiloxane (PDMS) ceiling chips. The progression of spermatogenesis, germ/Sertoli cell ratio, cell proliferation, seminiferous tubule area, and intratubular cell density were assessed by histological and immunohistochemical analyses. Terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labeling (TUNEL) assays and Peanut Agglutinin (PNA) lectin labeling were performed to analyze the Deoxyribonucleic Acid (DNA) integrity and differentiation step of in vitro‐produced spermatids.ResultsSequential two‐step protocols allowed the production of spermatids with a higher efficiency compared with the one‐step culture protocol. However, the efficiency was low, as less than 1.5% of tubules contained spermatids. Most of the in vitro‐produced spermatids contained unfragmented DNA and were at an early step of differentiation. Rare elongating spermatids could be detected in the cultured explants. Although complete in vitro spermatogenesis could not be obtained with PDMS ceiling chips, entry into meiosis was promoted in one‐step organotypic cultures.Discussion and conclusionComplete in vitro meiosis and the beginning of the elongation phase of spermiogenesis were obtained in a rat model using sequential culture methods. Because of their low efficiency, further work will be necessary to identify the culture conditions allowing the completion of spermiogenesis. These optimizations could pave the way for future applications, including the development of an in vitro fertility restoration procedure for childhood cancer survivors, which is still far from being clinically available.
The prognostic role of advanced hemodynamic variables in patients with left ventricular assist devices
Authors: Kanelidis Anthony J. , Siddiqi Umar , Miller Tamari , Belkin Mark , Li George , Smith Bryan , Kalantari Sara , Nguyen Ann , Chung Ben B. , Sarswat Nitasha , Kim Gene , Salerno Christopher , Jeevanandam Valluvan , Pinney Sean , Grinstein Jonathan 
Published: October 2022

AbstractBackgroundInvasive hemodynamic variables obtained from right heart catheterization have been used for risk‐stratifying patients with advanced heart failure (HF). However, there is a paucity of data on the prognostic value of invasive hemodynamic variables in patients with left ventricular assist devices (LVAD). We hypothesized that cardiac power output (CPO), cardiac power efficiency (CPE), and left ventricular stroke work index (LVSWI) can serve as prognostic markers in patients with LVADs.MethodsBaseline hemodynamic data from patients who had LVAD ramp studies at our institution from 4/2014 to 7/2018 were prospectively collected, from which advanced hemodynamic variables (CPO, CPE, and LVSWI) were retrospectively analyzed. Univariate and multivariable analyses were performed for hemocompatibility‐related adverse events (HRAE), HF admissions, and mortality.ResultsNinety‐one participants (age 61 ± 11 years, 34% women, 40% Black or African American, and 38% ischemic cardiomyopathy) were analyzed. Low CPE was significantly associated with mortality (HR 2.42, 95% CI 1.02–5.74, p = 0.045) in univariate analysis and Kaplan–Meier analysis (p = 0.04). Low LVSWI was significantly associated with mortality (HR 2.13, 95% CI 1.09–4.17, p = 0.03) in univariate analysis and Kaplan–Meier analysis (p = 0.02). CPO was not associated with mortality. CPO, CPE, and LVSWI were not associated with HRAE or HF admissions.ConclusionsAdvanced hemodynamic variables can serve as prognostic indicators for patients with LVADs. Low CPE and LVSWI are prognostic for higher mortality, but no variables were associated with HF admissions or HRAEs.
An ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for the simultaneous quantitation of 10 alkaloids of Corydalis Decumbentis Rhizoma preparation in dog plasma and its application to a pharmacokinetic study
Authors: Yu Ying , Sun Jiahui , Yang Chunjuan , Dong Hongrui , Wang Zhenyue , Wang Zhibin 
Published: October 2022

AbstractObjectiveA sensitive and rapid ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method was successfully applied to the determination of 10 alkaloids in beagle dog plasma following a single oral dose of Xiatianwu capsules and enteric‐coated capsules, with theophylline serving as the internal standard (IS).MethodsPlasma samples were preprocessed using liquid–liquid extraction (LLE) with ethyl acetate ahead to separation using a gradient elution procedure on a Waters ACQUITY UPLC HSS T3 column (1.8 μm, 100 × 2.1 mm). The mobile phase was composed of 0.1% formic acid solution and acetonitrile at the flow rate of 0.3 ml/min. Multiple reaction monitoring (MRM) was used to determine the analytes in the positive ion mode.ResultsThe calibration curves for 10 analytes demonstrated a high degree of linearity (r ≥ 0.9920). The lower limit of quantification (LLOQ) values for 10 alkaloids were all more than 1.074 ng/ml, and matrix effects varied from 94.25% to 106.15%. The mean extraction recovery of quality control samples at low (LQC), medium (MQC) and high (HQC) concentrations, as well as IS, was all more than 76.60%. The intra‐day and inter‐day precision (RSD) also satisfied the requirement. Simultaneously, the variation of assay accuracies (RE) was between 13.05% and 9.38%.ConclusionThe test was validated in accordance with regulatory bioanalytical guidelines and was found to be suitable for use in a pharmacokinetic investigation of these compounds in beagle dogs after oral administration of Xiatianwu general capsules and enteric‐coated capsules. The Cmax of 10 alkaloids ranged from 52.61 to 192.46 ng/ml after oral administration of Xiatianwu capsules, and from 67.50 to 247.36 ng/ml. The Tmax was between 0.59 and 1.33 h of Xiatianwu capsules, and between 1.08 and 2.00 h of enteric‐coated capsules. The t1/2 ranged from 3.18 to 7.47 h of general capsules, and from 6.01 to 11.36 h. AUC0‐t ranged from 181.06 to 722.74 ng·h/ml of Xiatianwu capsules, and from 275.03 to 884.17 ng·h/ml of enteric‐coated capsules. The Cmax of enteric‐coated capsules were significantly increased except for tetrahydropalmatine and berberine. Tmax of general capsules were less than 1 h, and of enteric‐coated capsules were less than 2 h. The t1/2 of dehydrocorydaline, palmatine, tetrahydrojatrorrhizine, jatrorrhizine and coptisine in enteric‐coated capsules was longer than that in ordinary capsule. The AUC0‐t and AUC0‐∞ of bicuculline, dehydrocorydaline, protopine, magnoflorine, tetrahydrojatrorrhizine, jatrorrhizine, berberine and coptisine were all significantly higher in enteric‐coated capsules.
Use of sorbitan sesquioleate in patch test preparations and patch testing with the substance—What do our results mean?
Authors: Sukakul Thanisorn , Bruze Magnus , Mowitz Martin , Svedman Cecilia 
Published: October 2022

AbstractBackgroundSorbitan sesquioleate (SSO) is a sorbitan fatty acid ester, an emulsifier used in topical products and certain patch test preparations. SSO may affect the patch test results. It has been debated whether to include the substance in the baseline series to avoid misinterpretation of the results.ObjectivesTo report the prevalence and simultaneous reactions of SSO with other patch test preparations containing SSO as an emulsifier.Materials and MethodsA retrospective analysis of 3539 dermatitis patients who underwent patch testing from 2016 to 2020 was performed.ResultsThe 5‐year SSO contact allergy prevalence was 0.48%, and 1.3% had a doubtful reaction. Patients with a stronger positive reaction (2+, 3+) were more likely to react simultaneously to other allergen preparations containing SSO (p value = 0.018). One patient with a strong reaction to SSO reacted positively to all SSO‐containing patch test preparations. Definite fragrance allergens could not be identified in the patients who had simultaneous reactions to SSO and fragrance mix (FM) I.ConclusionsPatch testing with allergen preparations containing SSO affected the patch test interpretation. Fragrance contact allergy could not be ruled out when a patient simultaneously reacted to SSO and FM I. Changing emulsifiers in patch test preparations would be advantageous.
Acoustic presence and vocal activity of North Atlantic right whales in the New York Bight: Implications for protecting a critically endangered species in a human‐dominated environment
Authors: Murray Anita , Rekdahl Melinda L. , Baumgartner Mark F. , Rosenbaum Howard C. 
Published: October 2022

AbstractNorth Atlantic right whale (NARW) distribution shifts have led to increased presence in the US mid‐Atlantic, which includes the New York Bight (NYB), an area with substantial vessel traffic. NARW vessel strikes are mitigated by a seasonal management area (SMA) that is active November–April. Within the SMA, vessels ≥ 19.8 m must travel at ≤10 knots. However, until recently, surveys of the NYB were not conducted after the NARW distribution shifted. Thus, it was unclear whether the SMA captured NARW presence in the NYB. Outside the SMA, voluntary speed restrictions are implemented over a limited area when NARW calls are acoustically detected; therefore, it was important to quantify NARW vocal activity. Acoustic recordings (2016–2020) were analyzed to determine NARW presence, vocal states, and diel pattern of vocal activity. NARWs were detected outside SMA boundaries, and medium/high vocal states (21–69 calls over 3–6 h) occurred while the SMA was inactive. Therefore, the SMA spatiotemporal boundaries should be revised. Vocal activity was highest at night (22:00–1:00), and NARWs were acoustically detected when they were not detected by aerial surveys, illustrating acoustic detections are a viable method for triggering mitigation measures when NARWs are vocalizing but are not visually observed.
Confirmatory reinforcement learning changes with age during adolescence
Authors: Chierchia Gabriele , Soukupová Magdaléna , Kilford Emma J. , Griffin Cait , Leung Jovita , Palminteri Stefano , Blakemore Sarah‐Jayne 
Published: October 2022

AbstractUnderstanding how learning changes during human development has been one of the long‐standing objectives of developmental science. Recently, advances in computational biology have demonstrated that humans display a bias when learning to navigate novel environments through rewards and punishments: they learn more from outcomes that confirm their expectations than from outcomes that disconfirm them. Here, we ask whether confirmatory learning is stable across development, or whether it might be attenuated in developmental stages in which exploration is beneficial, such as in adolescence. In a reinforcement learning (RL) task, 77 participants aged 11–32 years (four men, mean age = 16.26) attempted to maximize monetary rewards by repeatedly sampling different pairs of novel options, which varied in their reward/punishment probabilities. Mixed‐effect models showed an age‐related increase in accuracy as long as learning contingencies remained stable across trials, but less so when they reversed halfway through the trials. Age was also associated with a greater tendency to stay with an option that had just delivered a reward, more than to switch away from an option that had just delivered a punishment. At the computational level, a confirmation model provided increasingly better fit with age. This model showed that age differences are captured by decreases in noise or exploration, rather than in the magnitude of the confirmation bias. These findings provide new insights into how learning changes during development and could help better tailor learning environments to people of different ages.Research Highlights
Reinforcement learning shows age‐related improvement during adolescence, but more in stable learning environments compared with volatile learning environments.
People tend to stay with an option after a win more than they shift from an option after a loss, and this asymmetry increases with age during adolescence.
Computationally, these changes are captured by a developing confirmatory learning style, in which people learn more from outcomes that confirm rather than disconfirm their choices.
Age‐related differences in confirmatory learning are explained by decreases in stochasticity, rather than changes in the magnitude of the confirmation bias.
Retinoic acid effects on in vitro palatal fusion and WNT signaling
Authors: Roa Fuentes Laury Amelia , Bloemen Marjon , Carels Carine EL , Wagener Frank ADTG , Von den Hoff Johannes W 
Published: October 2022

AbstractRetinoic acid is the main active vitamin A derivate and a key regulator of embryonic development. Excess of retinoic acid can disturb palate development in mice leading to cleft palate. WNT signaling is one of the main pathways in palate development. We evaluated the effects of retinoic acid on palate fusion and WNT signaling in in vitro explant cultures. Unfused palates from E13.5 mouse embryos were cultured for 4 days with 0.5 μM, 2 μM or without retinoic acid. Apoptosis, proliferation, WNT signaling and bone formation were analyzed by histology and quantitative PCR. Retinoic acid treatment with 0.5 and 2.0 μM reduced palate fusion from 84% (SD 6.8%) in the controls to 56% (SD 26%) and 16% (SD 19%), respectively. Additionally, 2 μM retinoic acid treatment increased Axin2 expression. Retinoic acid also increased the proliferation marker Pcna as well as the number of Ki‐67‐positive cells in the palate epithelium. At the same time, the WNT inhibitors Dkk1, Dkk3, Wif1 and Sfrp1 were downregulated at least two‐fold. Retinoic acid also down‐regulated Alpl and Col1a2 gene expression. Alkaline phosphatase (ALP) activity was notably reduced in the osteogenic areas of the retinoic acid‐ treated palates. Our data suggest that retinoic acid impairs palate fusion and bone formation by upregulation of WNT signaling.
Open dialogue trainees' perspectives on learning processes and psychotherapeutic practice: A prospective focus group study
Authors: Buus Niels , Ong Ben , McCloughen Andrea 
Published: October 2022

AbstractOpen Dialogue is a collaborative approach to mental health care emphasizing integrated services and a dialogical psychotherapy approach. Open Dialogue training programs eschew traditional didactic teaching of technical therapeutic skills in favor of more experiential learning processes. It is unclear how these training programs affect trainees and shape their perspectives on Open Dialogue. Our aim was to follow up a group of Australian Open Dialogue trainees and explore their perspectives on learning processes and psychotherapeutic practice. We utilized a prospective focus group design with data from audio‐recorded focus groups convened before (n = 2) and after (n = 3) participants completing an advanced Open Dialogue training program. Data were subjected to reflective thematic analysis. We identified the theme “Extending possibilities by holding ideas lightly,” which represented a universal principle that participants applied to multiple aspects of their practice, for example, favoring multiple perspectives and approaches to therapy, including those other than Open Dialogue. This theme had two sub‐themes: (1) “Allowing intimacy by being aware of personal biographies” and (2) “Learning by joining others,” which reflected an increased willingness by participants to reflect on and share their inner experiences and an emphasis on joint experiential exercises in the training program. “Extending possibilities by holding ideas lightly” facilitated a means of incorporating a dialogical perspective into existing practices thus avoiding the potential barriers to a wholesale implementation of Open Dialogue. Findings indicated that the participants were not learning how to practice a therapeutic technique or propositional knowledge, but were socialized into a dialogical way of being.