bluuebunny/crossref_metadata_2025_split huggingface dataset:
Canadian healthcare capacity gaps for disease-modifying treatment in Huntington’s disease: a survey of current practice and modelling of future needs
Authors: Bénard Angèle , Chouinard Sylvain , Leavitt Blair R , Budd Nathalie , Wu Jennifer W , Schoffer Kerrie 
Published: June 2022

ObjectivesDisease-modifying therapies in development for Huntington’s disease (HD) may require specialised administration and additional resource capacity. We sought to understand current and future capacity for HD management in Canada considering the possible introduction of an intrathecal (IT) disease-modifying treatment (DMT).Design, setting and participantsUsing a case study, mixed methods framework, online surveys followed by semistructured interviews were conducted in late 2020 and early 2021. Neurologists from Canadian HD (n=16) and community (n=11) centres and social workers (n=16) were invited to complete online surveys assessing current HD management and potential capacity to support administration of an IT DMT.Outcome measuresSurvey responses, anticipated demand and assumed resource requirements were modelled to reveal capacity to treat (ie, % of eligible patients) by centre. Resource bottlenecks and incremental support required (full-time equivalent, FTE) were also determined.ResultsNeurologists from 15/16 HD centres and 5/11 community centres, plus 16/16 social workers participated. HD centres manage 94% of patients with HD currently seeking care in Canada, however, only 20% of IT DMT-eligible patients are currently seen by neurologists. One-third of centres have no access to nursing support. The average national incremental nursing, room, neurologist and social worker support required to provide IT DMT to all eligible patients is 0.73, 0.36, 0.30 and 0.21 FTE per HD centre, respectively. At peak demand, current capacity would support the treatment of 6% of IT DMT-eligible patients. If frequency of administration is halved, capacity for IT-DMT administration only increases to 11%.ConclusionsIn Canada, there is little to no capacity to support the administration of an IT DMT for HD. Current inequitable and inadequate resourcing will require solutions that consider regional gaps and patient needs.
Living beyond expectations: a qualitative study into the experience of long-term survivors with pleural mesothelioma and their carers
Authors: Johnson Matthew , Allmark Peter , Tod Angela 
Published: June 2022

BackgroundMalignant pleural mesothelioma (MPM) is characterised by poor prognosis and limited treatment options. However, a minority of patients can survive well beyond these bleak estimates. Little is known about the specific experiences and needs of long-term survivors and families.Study purposeThe study aimed to gain in-depth understanding of the experiences of patients diagnosed with MPM 3 or more years, along with their main carer, and to determine the care and support needs of this group.Participants and settingPeople diagnosed with MPM 3 or more years were recruited via asbestos and mesothelioma social media and support groups. Potential participants were asked to identify someone who acted as their main carer.MethodThe study employed a cross-sectional qualitative interview design. A topic guide aided a conversational interview style, conducted remotely and recorded. Patient and carer pairs were interviewed jointly when possible, but were given an option for separate interviews if preferred. Fifteen patients, with 14 identifying a main carer, consented to participation.AnalysisRecorded interviews were transcribed verbatim, and then anonymised by the interviewer. Framework analysis was used to analyse the data iteratively and to develop final themes.FindingsThree themes were developed. Participants ‘Living beyond expectations’ remained acutely aware that MPM was incurable, but developed a range of coping strategies. Periods of disease stability were punctuated with crises of progression or treatment ending, straining coping. ‘Accessing treatment’ was important for patients and carers, despite the associated challenges. They were aware options were limited, and actively sought new treatments and clinical trials. ‘Support needs’ were met by healthcare professionals, voluntary groups and social media networks.ConclusionsManaging patients via regional MPM multidisciplinary teams, facilitating equal access to treatment and trials, could reduce patient and carer burden. Greater awareness and support around crisis points for this group could improve care.
Cosmological dynamical systems in modified gravity
Authors: Böhmer Christian G. , Jensko Erik , Lazkoz Ruth 
Published: June 2022

AbstractThe field equations of modified gravity theories, when considering a homogeneous and isotropic cosmological model, always become autonomous differential equations. This relies on the fact that in such models all variables only depend on cosmological time, or another suitably chosen time parameter. Consequently, the field equations can always be cast into the form of a dynamical system, a successful approach to study such models. We propose a perspective that is applicable to many different modified gravity models and relies on the standard cosmological density parameters only, making our choice of variables model independent. The drawback of our approach is a more complicated constraint equation. We demonstrate our procedure studying various modified gravity models and show how much generic information can be extracted before a specific model is considered.
Strength Abilities and Serve Reception Efficiency of Youth Female Volleyball Players
Authors: Pawlik Damian , Dziubek Wioletta , Rogowski Łukasz , Struzik Artur , Rokita Andrzej 
Published: June 2022

Success in volleyball largely depends on motor abilities, particularly on maximum strength, power, jumping, and speed performance. However, a small number of studies assess the relationship between motor abilities and the effectiveness of volleyball technical skills. Therefore, the aim of the study was to assess the impact of the strength of the upper and lower limbs on the efficiency of serve reception during a 2 vs. 2 game, as well as to evaluate the results of motor measurements in the context of determining the usefulness of current testing procedures. The study involved a carefully chosen group of 12 girls aged 12–13 years (body height:

176.5
±
4.2

cm, body mass:

58.6
±
5.1

kg, and training experience:

43
±
15

months) selected for the Lower Silesian Regional Volleyball Team. The following tests were conducted: handgrip strength with a hand dynamometer, bent-arm hang, 2 kg medicine ball throw, shoulder joint internal rotators (IR) peak torque, standing long jump, spike jump, and countermovement jump. The measurements of the shoulder joint IR peak torque were performed under isometric (at 10°, 35°, and 65° rotation angles) and isokinetic (at 60°/s, 180°/s, and 300°/s) conditions. The efficiency of serve reception was evaluated during a 2 vs. 2 games by using Data Volley statistical software. The strongest positive relationships were observed between the serve reception efficiency and the peak torque and power of the shoulder joint IR, the medicine ball throw distance, and handgrip strength. Jumping variables showed no associations with efficient of serve reception. Consequently, we suggest adding protocols to volleyball training that include strength exercises aimed at developing the IR muscle group. The isokinetic upper limb test should be introduced as a valid tool in selection process. Coaches who do not have access to modern research equipment should use the medicine ball throw test to evaluate strength abilities as an alternative assessment of the serve reception efficiency.
Structural Racism and Cancer: Calls to Action for Cancer Researchers to Address Racial/Ethnic Cancer Inequity in the United States
Authors: Best Alicia L. , Roberson Mya L. , Plascak Jesse J. , Peterson Caryn E. , Rogers Charles R. , Hastert Theresa A. , Molina Yamilé 
Published: June 2022

Abstract
As leaders with the American Society of Preventive Oncology (ASPO) Cancer Health Disparities Special Interest Group, we describe the role of structural racism in perpetuating cancer health inequity historically, and potential implications of COVID-19 in exacerbating the effects of structural racism on patients with cancer seeking screening, diagnostic care, treatment, and survivorship support. As a strategy to reduce cancer inequities in the United States, we provide the following calls to action for cancer researchers to help alleviate the burden of structural racism: (i) identify and name structural racism while describing its operation within all aspects of scientific research; (ii) comprehensively integrate discussions on structural racism into teaching, mentoring, and service activities; and (iii) understand and support community actions to address structural racism.
Cancer Screening Companies Are Rapidly Proliferating: Are They Ready for Business?
Authors: Fernandez-Uriarte Amaia , Pons-Belda Oscar D. , Diamandis Eleftherios P. 
Published: June 2022

Abstract
Cancer screening has been a major research front for decades. The classical circulating biomarkers for cancer (such as PSA, CEA, CA125, AFP, etc.) are neither sensitive nor specific and are not recommended for population screening. Recently, circulating tumor DNA (ctDNA) emerged as a new pan-cancer tumor marker, with much promise for clinical applicability. ctDNA released by tumor cells can be used as a proxy of the tumor burden and molecular composition. It has been hypothesized that if ctDNA is extracted from plasma and analyzed for genetic changes, it may form the basis for a non-invasive cancer detection test. Lately, there has been a proliferation of “for-profit” companies that will soon offer cancer screening services. Here, we comment on Grail, Thrive, Guardant, Delfi, and Freenome. Previously, we identified some fundamental difficulties associated with this new technology. In addition, clinical trials are exclusively case–control studies. The sensitivities/specificities/predictive values of the new screening tests have not been well-defined or, the literature-reported values are rather poor. Despite these deficiencies some of the aforementioned companies are already testing patients. We predict that the premature use of ctDNA as a cancer screening tool may add another disappointment in the long history of this field.
Criteria for Acceptable Dietary Intake Biomarkers
Authors: Prentice Ross L. 
Published: June 2022

Abstract
Dietary intake biomarkers that can be written as actual intake, plus ‘error’ that is independent of actual intake and confounding factors can substitute for actual intake in disease association analyses. Also, such biomarkers can be used to develop calibration equations using self-reported diet and participant measures, and biomarker-calibrated intakes can be calculated in larger cohorts for use in disease association analyses. Criteria for biomarkers, and for biomarker-calibrated intakes, arise by working back from properties needed for valid disease association analyses. Accordingly, arguments for a potential biomarker are strengthened if error components are small relative to actual intakes, and important sources of reduced sensitivity or specificity are not apparent. Feeding study biomarker development can then involve regression of actual intake on putative biomarkers, with regression R2 values playing a role in biomarker evaluation. In comparison, ‘predictive’ biomarker status, as argued in this issue by Freedman and colleagues for 24-hour urinary sucrose plus fructose as biomarker for total sugars, involves regression of potential biomarker on actual intake and other variables, with parameter stability across populations and limited within-person variability as criteria. The choice of criteria for biomarkers and for biomarker-calibrated intakes, is discussed here, in the context of total sugars intake.
See related article by Freedman et al., p. 1227
ABBV-011, A Novel, Calicheamicin-Based Antibody–Drug Conjugate, Targets SEZ6 to Eradicate Small Cell Lung Cancer Tumors
Authors: Wiedemeyer Wolf R. , Gavrilyuk Julia , Schammel Alexander , Zhao Xi , Sarvaiya Hetal , Pysz Marybeth , Gu Christine , You Monica , Isse Kumiko , Sullivan Theodore , French Dorothy , Lee Christina , Dang Angeline T. , Zhang Zhaomei , Aujay Monette , Bankovich Alexander J. , Vitorino Philip 
Published: June 2022

Abstract
In the past year, four antibody–drug conjugates (ADC) were approved, nearly doubling the marketed ADCs in oncology. Among other attributes, successful ADCs optimize targeting antibody, conjugation chemistry, and payload mechanism of action. Here, we describe the development of ABBV-011, a novel SEZ6-targeted, calicheamicin-based ADC for the treatment of small cell lung cancer (SCLC). We engineered a calicheamicin conjugate that lacks the acid-labile hydrazine linker that leads to systemic release of a toxic catabolite. We then screened a patient-derived xenograft library to identify SCLC as a tumor type with enhanced sensitivity to calicheamicin ADCs. Using RNA sequencing (RNA-seq) data from primary and xenograft SCLC samples, we identified seizure-related homolog 6 (SEZ6) as a surface-expressed SCLC target with broad expression in SCLC and minimal normal tissue expression by both RNA-seq and IHC. We developed an antibody targeting SEZ6 that is rapidly internalized upon receptor binding and, when conjugated to the calicheamicin linker drug, drives potent tumor regression in vitro and in vivo. These preclinical data suggest that ABBV-011 may provide a novel treatment for patients with SCLC and a rationale for ongoing phase I studies (NCT03639194).
Enabling Programmatic Data Mining as Musicking: The Fluid Corpus Manipulation Toolkit
Authors: Tremblay Pierre Alexandre , Roma Gerard , Green Owen 
Published: June 2022

AbstractThis article presents a new software toolbox to enable programmatic mining of sound banks for musicking and musicking-driven research. The toolbox is available for three popular creative coding environments currently used by “techno-fluent” musicians. The article describes the design rationale and functionality of the toolbox and its ecosystem, then the development methodology—several versions of the toolbox have been seeded to early adopters who have, in turn, contributed to the design. Examples of these early usages are presented, and we describe some observed musical affordances of the proposed approach to the exploration and manipulation of music corpora, as well as the main roadblocks encountered. We finally reflect on a few emerging themes for the next steps in building a community around critical programmatic mining of sound banks.
Comparison of geographical isolates of Bursaphelenchus tadamiensis (Tylenchomorpha: Aphelenchoididae) with remarks on its preferred habitat
Authors: Kanzaki Natsumi , Hamaguchi Keiko , Ide Tatsuya 
Published: June 2022

Summary
Bursaphelenchus tadamiensis, which was initially isolated from a stag beetle, Dorcus striatipennis, collected from sap flow of Quercus crispula in Fukushima, north-eastern Japan, was re-isolated three times from sap flow of Quercus spp. in western Japan. The re-isolated populations were mostly morphologically consistent with the type population, but the male bursal flap showed high variations in the newly collected populations. Molecularly, the type and new populations showed differences in the internal transcribed spacer region of ribosomal DNA and mitochondrial cytochrome oxidase subunit I gene, suggesting that the species is genetically divided into several local populations. The isolation pattern of B. tadamiensis, i.e., the species was initially isolated from sap flow-associated beetles and subsequently isolated from sap flow, suggests that the species prefers and is adapted to the sap flow environment as its habitat.
Cosmic Order in the Microcosm: Ethical Guidance in Post-Classical Astronomy Texts
Authors: Morrison Robert G. 
Published: June 2022

Abstract
This article is the first to focus on statements about ethical guidance in post-classical astronomy texts. A number of astronomers in post-classical Islamic societies remarked that the study of astronomy, specifically the mathematical analysis of the uniform motions of the celestial orbs, had ethical benefits. These astronomers’ statements are significant because, through them, scholars can learn more about the role of reason in Islamic thought and about sources of ethical guidance other than Sharīʿa and philosophical ethics. The details of the ethical guidance imparted by the study of astronomy tell us more about the relationship between astronomy and the disciplines of fiqh and kalām, respectively. The existence of ethical guidance in astronomy texts is additional evidence that post-classical astronomy texts were part of an Islamic intellectual tradition.
Are Surgeons of the Abdominal Core Health Quality Collaborative Following Guidelines in Umbilical and Epigastric Hernia Repair?
Authors: Malysz Oyola Anna M. , Faulkner Justin , Casas Brandon , Hooks William B. , Hope William W. 
Published: June 2022

Background Umbilical and epigastric hernias are among the top three most common hernia surgeries performed in the USA with varied techniques. The European and Americas Hernia Societies (EAHS) recently published guidelines for repair of umbilical and epigastric hernias. We evaluated how closely the general surgeons of the Abdominal Core Health Quality Collaborative (ACHQC) follow these guidelines and to identify areas for possible improvement. Method Data from patients undergoing elective and emergent umbilical or epigastric hernia repair from 2013 to 2021 were extracted from the ACHQC database. The procedures performed on eligible subjects were compared to those proposed by the EAHS guidelines. Data was reported as a percentage and a cutoff of 70% was selected to determine compliance. Results Based on these criteria, 11,088 patients were included and most of the recommendations, including appropriate preoperative antibiotic dosing (96.1% umbilical; 97.2% epigastric), permanent mesh selection (umbilical 97.8%; 96.1 epigastric), mesh fixation with suture (83.6% umbilical; 75.5% epigastric), use of mesh for open repair of hernias greater than 1 cm (83.6 umbilical; 85.7 epigastric), and primary defect closure during open (98.6% umbilical; 97.5% epigastric) and laparoscopic (99.6% umbilical; 100% epigastric) repair, were met. Discussion Surgeons of the ACHQC adhere to most of the published guidelines on umbilical and epigastric hernia repair. Further research is needed to reinforce or modify the existing recommendations. Standardization of surgical approach will facilitate additional research needed to improve procedural efficiency, while reducing negative outcomes and cost.
Impact of Difficult Dialogues on Social Justice Attitudes During a Multicultural Psychology Course
Authors: Hicks Elizabeth Tish , Alvarez María de la Caridad , Domenech Rodríguez Melanie M. 
Published: June 2022

Background Previous research shows that Multicultural Psychology courses can produce significant improvements in students’ cultural competence-related attitudes in in-person and online courses. Objective We evaluated the impact of adding a skills-focused group assignment (i.e., Difficult Dialogues) to an online asynchronous Multicultural Psychology course. Method Undergraduate students filled out a battery of self-report measures at the beginning and end of the course. Of the 192 total students, 107 were in course sections which completed a Difficult Dialogue (DD) group project, and 85 were in the teaching as usual (TAU) section. Results Students in DD groups had significantly greater pre-to post-increases on social justice behavioral intentions and perceived behavioral control compared to TAU. There were no statistical differences between-groups on measures of other cultural competence constructs, though there were statistically significant within-group improvements on all outcome measures. Conclusion Results suggest that the DD project had a particular impact on improving social justice behavioral intentions and perceived behavioral control. Teaching Implications These shifts underscore the importance of including opportunities for students to learn and practice specific skills in Multicultural Psychology courses, and that online courses can effectively provide these opportunities.
Clinical characteristics in unilateral cochlear nerve canal stenosis
Authors: Liang Wenqi , Wang Line , Wang Zhenxiao , Zhao Pengfei , Wang Qimei , Peng Kevin A 
Published: June 2022

Objective To characterize the clinical features of patients with congenital hearing loss and unilateral cochlear nerve canal stenosis (CNCS). Methods A retrospective review of 12 patients with unilateral CNCS diagnosed between January 2018 and December 2019 at a tertiary referral hospital was performed. Results Of the 12 patients identified, there were 6 males and 6 females. All patients presented with hearing loss, with no other chief complaints. Two patients had accessory auricles. Eleven patients had a severe to profound sensorineural hearing loss on the affected side, while 1 patient had an isolated high-frequency hearing loss. Nine patients demonstrated atresia of the cochlear nerve canal (CNC), while three patients had a stenotic, but patent, CNC. Conclusion Prompt radiologic diagnosis of patients with unilateral CNCS is important for patient counseling and appropriate rehabilitation.
Understanding Refugee Families’ Potentials for Supporting Children’s Mathematics Learning
Authors: Karsli-Calamak Elif , Ece Tuna Mana , Allexsaht-Snider Martha 
Published: June 2022

Background/Context: We lack a nuanced understanding of the potentials and needs of multilingual families, particularly those with forced displacement histories, in contributing to children’s mathematics learning. As educators seek to increase refugee students’ access to powerful mathematics learning, an understanding of how refugee families view and participate in their children’s mathematics learning can offer insights for how we might reach the goal of equitable educational access. Purpose/Focus of Study: In the GÖÇ-MAT project, we focused on developing equitable mathematics teaching practices with teachers (K–3) in schools highly populated with refugee children. The research that we present here, drawing on notions of community cultural wealth capital, offers a multifaceted view of how families of young children with refugee status articulated understandings of their roles in children’s mathematics learning. Setting: Our fieldwork took place in four different cities highly populated by people with refugee status in Turkey, the country located at the center of the worldwide trend of mass migration. Participants: We examined data from families (N = 54, mainly from Syria) who participated in the family engagement component of the larger project, carried out through multilingual family mathematics workshops. Research Design: We employed qualitative research methods and conducted two-year-long observations and video recordings in the context of multilingual family mathematics workshops. In the workshops, families, teachers, and researchers engaged in patterns and early algebra activities, as well as in family conversations facilitated through open-ended prompts, mathematics picture books, and educational journey maps. Over two years, we collected data comprising recorded dialogues with families, artifacts produced in the workshops, and video data of families’ mathematical interactions. Findings: Our analysis yielded two key understandings: (1) Family engagement practices around mathematics set a context to realize the nuanced nature of refugee families’ cultural wealth and efforts for their children’s education; and (2) refugee families’ knowledge of mathematics itself as a discipline and their mathematical capital, which are typically not recognized in school contexts, can serve as resources for mathematics teaching. Conclusions/Recommendations: The findings provide insight for teachers, researchers, and policy makers about how we might engage multilingual children and families with refugee status in powerful ways in mathematics education.