bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tourism policies and governance.
Authors: Bui Huong T. , Tran Thanh D. , Pham Long H. , Nghiem-Phu Binh 
Published: February 2022

Abstract

The current chapter focuses on tourism development post 1975. An analysis of tourism policy and governance in Vietnam cannot set aside the evolution of the Marxist political economic doctrine regulating the socio-economic system of the country since 1975. The transition from the central plan to the market-driven economy has been reflected in tourism policy making and implementation. Owing to its high international integration, its exceptional vulnerability to changes in global trends while being well connected to domestic consumption and mobilization of resources for post-war development, tourism mirrors the notion of a transitional economy better than any other sector. Current trends towards environmental and cultural protection also clearly imprint on the policy of tourism development.
Heritage conservation and tourism: the present and future of the past.
Authors: Bui Huong T. , Le Andrew , Jones Thomas E. 
Published: February 2022

Abstract

This chapter examines the symbiosis of heritage conservation and tourism development at a UNESCO (United Nations Educational, Scientific and Cultural Organization) cultural heritage site, one of the most popular touristic sites in Vietnam. Bui, Le and Jones present findings derived from a longitudinal study over 5 years spanning before and during the COVID-19 pandemic (from 2016 to 2020). Although Hoi An has dramatically benefited from mass tourism, the excessive increase in visitor numbers and concentration in the core heritage zone of the city has negatively impacted the economic wealth of the residents of the ancient town. COVID-19 halted the development of tourism, which attracts attention to the overdependence of the city on tourism, and offers an opportunity for administrators to rethink and revise Hoi An's existing tourism policies.
Vietnam tour operators and responsible tourism: a behavioural approach.
Authors: Bui Quynh N. , Phi Giang T. , Le Andrew 
Published: February 2022

Abstract

The essence of responsible tourism (RT) is that it is not merely a solution to sustainable development either by the types of products or by the scale of operation, but a fundamental change in a set of values and actions that results in an improvement of tourism activities involving all stakeholders including tourists, tourism service suppliers, the local community and tourism managers. With their unique position in the tourism system, tour operators serve as the hub for connecting diverse stakeholders in tourism, ranging from tourists to the local community to local destination authorities. A tour operator can offer RT products and services to motivate and educate tourists in consuming tourism in responsible ways and can concurrently improve awareness in local communities as well as contributing benefits to the tourism destination across the three aspects of the economy, society and the environment. Furthermore, these tourism enterprises know how to reach visitors through publications and the media, thereby connecting sustainable tourism destinations with customers. Despite tour operators' essential role, there exists a gap in the literature regarding their RT behaviours and implementation in the context of Vietnam. This chapter thus seeks to bridge this gap through a qualitative research approach.
Characteristic studies on positive and negative streamers of double-sided pulsed surface dielectric barrier discharge
Authors: JIANG Yan , PENG Bangfa , LIU Zhengyan , JIANG Nan , LU Na , SHANG Kefeng , LI Jie 
Published: February 2022

Abstract
The mechanisms of streamer generation and propagation in double-sided pulsed surface dielectric barrier discharge (SDBD) on both sides have been analyzed and investigated by experiment and numerical simulation. The fully exposed asymmetric SDBD has two discharge processes located on the high voltage electrode (HVE) side and the ground electrode (GE) side. Discharge images of the HVE side and GE side are taken by a digital camera under continuous pulse and ICCD (Intensified Charge Coupled Device) is utilized to diagnose the generation and propagation of streamers in single pulse discharge. In order to understand the physical mechanisms of streamer evolution more deeply, we establish a 2D simulation model and analyze it from the aspects of electron density, ion density, reduced electric field and electron impact ionization source term. The results show that the primary and secondary discharges on the HVE side and the GE side of the double-sided SDBD are composed of positive streamer and negative streamer, respectively. On the HVE side, the accumulation of positive charges on the dielectric surface causes the direction of the electric field to reverse, which is the principal factor for the polarity reversal of the streamer. On the GE side, both the negative charges accumulated on the dielectric surface and the falling voltage are the key factors for the streamer polarity switch.
Temporal dissonance between group size and its benefits requires whole-of-lifecycle measurements
Authors: Hearn Lucas R , Parslow Ben A , Stevens Mark I , Schwarz Michael P 
Published: February 2022

Abstract
The benefits of living in groups drive the evolution of sociality, and these benefits could vary across a life-cycle. However, there may be experimental problems in linking group size at one time in a life-cycle to benefits that only become apparent later on when group size has changed, leading to what we call “temporal dissonance”. In the only known social colletid bee, Amphylaeus morosus, parasite pressures arise at various times throughout the life-cycle from different parasitoid species. Amphylaeus morosus is impacted by eight different parasitoid species operating at different host-colony phenology phases, including five species of Gasteruption wasps, a bombyliid fly and two mutillid wasp species. We found that, as the reproductive season progressed, the number of host adults in a nest declined, often to zero, but the presence of even one adult host female during late brood-rearing stages appeared to offer substantial brood protection against mutillids. We propose that the apparent benefits of colony size at one point in time may not reflect the benefits that become apparent at a later point in the season, leading to a temporal dissonance between group size and its later fitness benefits. We also show that A. morosus is strongly protogynous, with variation in parasitoid pressure across the reproductive phenology distorting operational sex ratios away from initial investment ratios. Combined, our data suggest that seasonal variation in parasitoid pressure may have major consequences for understanding social evolution, but these kinds of consequences are largely unexplored in current studies of insect social evolution.
MRI tumour regression grade in locally recurrent rectal cancer
Authors: Voogt Eva L.K. , Nordkamp Stefi , van Zoggel Desley M.G.I. , Daniëls-Gooszen Alette W. , Nieuwenhuijzen Grard A.P. , Bloemen Johanne G. , Creemers Geert-Jan , Cnossen Jeltsje S. , van Lijnschoten Gesina , Burger Jacobus W.A. , Rutten Harm J.T. , Nederend Joost 
Published: February 2022

Abstract

Background
This study aimed to investigate the agreement between magnetic resonance tumour regression grade (mrTRG) and pathological regression grade (pTRG) in patients with locally recurrent rectal cancer (LRRC). Also, the reproducibility of mrTRG was investigated.

Methods
All patients with LRRC who underwent a resection between 2010 and 2018 after treatment with induction chemotherapy and neoadjuvant chemo(re)irradiation in whom a restaging MRI was available were retrospectively selected. All MRI scans were reassessed by two independent radiologists using the mrTRG, and the pTRG was reassessed by an independent pathologist. The interobserver agreement between the radiologists as well as between the radiologists and the pathologist was assessed with the weighted kappa test. A subanalysis was performed to evaluate the influence of the interval between imaging and surgery.

Results
Out of 313 patients with LRRC treated during the study interval, 124 patients were selected. Interobserver agreement between the radiologists was fair (k = 0.28) using a two-tier grading system (mrTRG 1–2 versus mrTRG 3–5). For the lead radiologist, agreement with pTRG was moderate (k = 0.52; 95 per cent c.i. 0.36 to 0.68) when comparing good (mrTRG 1–2 and Mandard 1–2) and intermediate/poor responders (mrTRG 3–5 and Mandard 3–5), and the agreement was fair between the other abdominal radiologist and pTRG (k = 0.39; 95 per cent c.i. 0.22 to 0.56). A shorter interval (less than 7 weeks) between MRI and surgery resulted in an improved agreement (k = 0.69), compared with an interval more than 7 weeks (k = 0.340). For the lead radiologist, the positive predictive value for predicting good responders was 95 per cent (95 per cent c.i. 71 per cent to 99 per cent), whereas this was 56 per cent (95 per cent c.i. 44 per cent to 66 per cent) for the other radiologist.

Conclusion
This study showed that, in LRRC, the reproducibility of mrTRG among radiologists is limited and the agreement of mrTRG with pTRG is low. However, a shorter interval between MRI and surgery seems to improve this agreement and, if assessed by a dedicated radiologist, mrTRG could predict good responders.
Efficacy of endoscopic clip closure for nonperforated muscle layer exposure during esophageal endoscopic submucosal dissection
Authors: Yamaguchi Hayato , Fukuzawa Masakatsu , Kawai Takashi , Uchida Kumiko , Koyama Yohei , Madarame Akira , Morise Takashi , Sugimoto Akihiko , Kono Shin , Naito Sakiko , Itoi Takao 
Published: February 2022

Abstract
Exposure of the muscle layer during endoscopic submucosal dissection (ESD) in the esophagus can lead to complications such as fever and pain. Although closure with endoscopic clips is widely used when perforation is a major complication, its value when the exposed muscle layer is not perforated is unclear. Data for 104 lesions in 104 patients who underwent esophageal ESD between 2008 and 2020 were retrospectively analyzed. Patients with multiple tumors, those who experienced procedure-related adverse events such as aspiration pneumonitis, perforation during ESD, or delayed bleeding, and those in whom the muscle layer was not exposed were excluded. The clinical course of inflammation after ESD in patients in whom the muscle layer was exposed was examined according to whether endoscopic clips were used for closure. A significantly greater number of patients had a temperature ≤ 37.5°C in the clip closure group than in the nonclip closure group (≤37.5°C/≥37.6°C, 47/14 vs. 25/18, respectively, P = 0.040). Furthermore, significantly more patients in the clip closure group had a white blood cell count ≤10,000/μL (≤10,000/μL/&gt;10,000/μL, 51/10 vs. 21/22, P &lt; 0.001) and a C-reactive protein level &lt; 1.0 mg/dL (&lt;1.0 mg/dL/≥1.0 mg/dL, 40/21 vs. 36/7, P = 0.040) in the 24 hour post-ESD. The results were not changed after propensity score matching. Closure with endoscopic clips reduces inflammation after esophageal ESD with nonperforated muscle layer exposure. Even if there is no obvious perforation during ESD, closure of the exposed muscle layer with endoscopic clips may contribute to the clinical course post-ESD.
Cardiorenal risk of celecoxib compared with naproxen or ibuprofen in arthritis patients: insights from the PRECISION trial
Authors: Obeid Slayman , Libby Peter , Husni Elaine , Wang Qiuqing , Wisniewski Lisa M , Davey Deborah A , Wolski Katherine E , Xia Feng , Bao Weihang , Walker Chris , Ruschitzka Frank , Nissen Steven E , Lüscher Thomas F 
Published: February 2022

Abstract

Aims
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used drugs, both prescribed and over the counter. The long-term cardiovascular safety of NSAIDs in patients with arthritis has engendered controversy. Concerns remain regarding the relative incidence and severity of adverse cardiorenal effects, particularly in arthritis patients with established cardiovascular (CV) disease or risk factors for disease as illustrated by the PRECISION (Prospective Randomized Evaluation of Celecoxib Integrated Safety vs. Ibuprofen Or Naproxen) trial participants (NCT00346216).
We further investigated whether the selective COX-2 Inhibitor celecoxib has a superior cardiorenal safety profile compared with ibuprofen or naproxen in the PRECISION population.

Methods and results
Twenty-four thousand eighty-one patients who required NSAIDs for osteoarthritis or rheumatoid arthritis (RA) and had increased CV risk randomly received celecoxib, ibuprofen, or naproxen. The current pre-specified secondary analysis assessed the incidence, severity, and NSAID-related risk of the pre-specified composite cardiorenal outcome (adjudicated renal event, hospitalization for congestive heart failure, or hospitalization for hypertension) in the intention-to-treat (ITT) population. An on-treatment analysis assessed safety in those taking the study medication. Following a mean treatment duration of 20.3 ± 16.0 months and a mean follow-up of 34.1 ± 13.4 months, the primary cardiorenal composite outcome occurred in 423 patients (1.76%) in the ITT population. Of these 423 patients, 118 (28%) were in the celecoxib, 166 (39%) in the ibuprofen, and 139 (33%) in the naproxen group. In a multivariable Cox regression model adjusted for independent clinical variables, celecoxib showed a significantly lower risk compared with ibuprofen [hazard ratio (HR) 0.67, confidence interval (CI) 0.53–0.85, P = 0.001) and a trend to lower risk compared with naproxen (HR 0.79, CI 0.61–1.00, P = 0.058). In the ITT analysis, clinically significant renal events occurred in 220 patients with events rates of 0.71%, 1.14%, and 0.89% for celecoxib, ibuprofen, and naproxen, respectively (P = 0.052), while in the on-treatment analysis the rates were 0.52%, 0.91%, and 0.78% (P &lt; 0.001).

Conclusion
In the current era, long-term NSAID use was associated with few cardiorenal events in arthritis patients. At the doses studied, celecoxib displayed fewer renal events and hence more favourable cardiovascular safety compared with ibuprofen or naproxen. These results have considerable clinical implications for practitioners managing individuals with chronic arthritis pain and high risk of impaired renal function and/or heart failure.
Clinical Trial Registration: NCT00346216
Multi-lead pacing for cardiac resynchronization therapy in heart failure: a meta-analysis of randomized controlled trials
Authors: Elliott Mark K , Mehta Vishal , Wijesuriya Nadeev , Sidhu Baldeep S , Gould Justin , Niederer Steven , Rinaldi Christopher A 
Published: February 2022

Abstract

Aims
Multi-lead pacing is a potential therapy to improve response to cardiac resynchronization therapy (CRT) by providing rapid activation of the myocardium from multiple sites. Here, we perform a meta-analysis of randomized controlled trials to assess the efficacy of multi-lead pacing.

Methods and results
A literature search was performed which identified 251 unique records. After screening, 6 studies were found to meet inclusion criteria, with 415 patients included in the meta-analysis. Four studies performed multi-lead pacing with two left ventricular (LV) leads and one right ventricular (RV) lead. One study used two RV leads and one LV lead, and one study used both configurations. There was no difference between multi-lead pacing and conventional CRT in LV end-systolic volume [mean difference (MD) −0.54 mL, P = 0.93] or LV ejection fraction (MD 1.42%, P = 0.40). There was a borderline significant improvement in Minnesota Living With Heart Failure Questionnaire score for multi-lead pacing vs. conventional CRT (MD −4.46, P = 0.05), but the difference was not significant when only patients receiving LV-only multi-lead pacing were included (MD −3.59, P = 0.25). There was also no difference between groups for 6-min walk test (MD 15.06 m, P = 0.38) or New York Heart Association class at follow-up [odds ratio (OR) 1.49, P = 0.24]. There was no difference in mortality between groups (OR 1.11, P = 0.77).

Conclusion
This meta-analysis does not support the use of multi-lead pacing for CRT delivery. However, significant variation between studies was noted, and therefore a benefit for multi-lead pacing in select patients cannot be excluded, and further investigation may be warranted.
Mid-term outcomes of isolated tricuspid valve surgery according to preoperative clinical and functional staging
Authors: Sala Alessandra , Lorusso Roberto , Zancanaro Edoardo , Carino Davide , Bargagna Marta , Bisogno Arturo , Lapenna Elisabetta , Ruggeri Stefania , Meneghin Roberta , Schiavi Davide , Buzzatti Nicola , Denti Paolo , Monaco Fabrizio , Agricola Eustachio , Maisano Francesco , Alfieri Ottavio , Castiglioni Alessandro , De Bonis Michele 
Published: February 2022

Abstract

OBJECTIVES
This study aimed at assessing mid-term outcomes of patients undergoing isolated tricuspid valve (TV) surgery based on a preoperative baseline clinical and functional classification.

METHODS
All patients treated with isolated TV repair or replacement from March 1997 to May 2020 at a single institution were retrospectively reviewed and assessed for mid-term postoperative outcome according to a novel classification [stages 1–5 related to the absence or presence and extent of right heart failure (RHF)]. Kaplan–Meier survival curves were used to estimate mid-term survival. Competing risk analysis for time to cardiac death and hospitalizations for RHF were also carried out.

RESULTS
Among the 172 patients included, 129 (75%) underwent TV replacement and 43 (25%) TV repair. At follow-up (median 4.2 years [2.1–7.5]), there were 23 late deaths. At 5 years, overall survival was 100% in stage 2, 88 ± 4% in stage 3 and 60 ± 8% in stages 4–5 (P = 0.298 and P = 0.001, respectively). Cumulative incidence function of cardiac death at 5 years was 0%, 8.6 ± 3.76% and 13.2 ± 5% for stages 2, 3 and 4 and 5, respectively. At follow-up, cumulative incidence function of re-hospitalizations for RHF was 0% for stage 2, 20 ± 5% for stage 3 and 20 ± 6.7% for stages 4 and 5 (P = 0.118 and P = 0.039, respectively).

CONCLUSIONS
Both short- and mid-term outcomes support early referral for surgery in isolated TV disease, with excellent survival at 5 years and no further hospitalizations for RHF.
Impact of changes in imports and farmed salmon on wild-caught fish prices in Australia
Authors: Pascoe Sean , Schrobback Peggy , Hoshino Eriko , Curtotti Robert 
Published: February 2022

AbstractIn this study, we develop a dynamic Inverse Almost Ideal Demand System model to derive own- and cross-price flexibilities for wild-caught fish, Australian farmed salmon and imports of fresh and frozen fish. We find that the growth of fresh fish imports and Australian farmed salmon production have both individually had a significant negative impact on the prices received for Australian wild-caught species, particularly the lower valued species. Continued growth in imports and the farmed salmon sector may negatively impact prices and hence profitability in wild-caught fisheries in Australia in the future.
Responding to the Needs of Persons Living With Dementia and Their Caregivers During the COVID-19 Pandemic: Lessons From the Care Ecosystem
Authors: Merrilees Jennifer , Robinson-Teran Joanne , Allawala Mahnoor , Dulaney Sarah , Rosenbloom Michael , Lum Hillary D , Sawyer Robert John , Possin Katherine L , Bernstein Sideman Alissa 
Published: February 2022

Abstract

Background and Objectives
The coronavirus disease 2019 (COVID-19) pandemic created challenges for persons with dementia, their caregivers, and programs that support them. The Care Ecosystem (CE) is a model of dementia care designed to support people with dementia and their family caregiver dyads through ongoing contact with a care team navigator (CTN) and an expert clinical team. CTNs provide support, education, and resources and help dyads manage dementia-related concerns as they evolve over the course of the disease. We aimed to understand how the CE responded to the needs of dyads during the initial 3 months of the COVID-19 pandemic.

Research Design and Methods
We conducted a survey and qualitative interviews with staff members from 4 established CE programs located in 4 different states to explore (a) challenges dyads voiced during the pandemic, (b) CE staff approaches to addressing the needs of dyads, and (c) programmatic challenges faced and lessons learned.

Findings
Nine staff members from 4 CE programs with an active collective caseload of 379 dyads were interviewed. Themes were identified that included dyad concerns regarding fear of illness, changing attitudes toward long-term care, decreased availability of services and resources, and impacts on patient and caregiver health and well-being. Programmatic challenges included maintaining effective communication with dyads and program staff, technological readiness, workflow restructuring, and program sustainability.

Discussion and Implications
Approaches in supporting people with dementia and their caregivers should demonstrate flexibility, responsivity, and creativity, and these findings provide insight for understanding how dementia care programs can be positioned to offer continuous support for this vulnerable population.
Assessing species coverage and assembly quality of rapidly accumulating sequenced genomes
Authors: Feron Romain , Waterhouse Robert M 
Published: February 2022

Abstract

Background
Ambitious initiatives to coordinate genome sequencing of Earth's biodiversity mean that the accumulation of genomic data is growing rapidly. In addition to cataloguing biodiversity, these data provide the basis for understanding biological function and evolution. Accurate and complete genome assemblies offer a comprehensive and reliable foundation upon which to advance our understanding of organismal biology at genetic, species, and ecosystem levels. However, ever-changing sequencing technologies and analysis methods mean that available data are often heterogeneous in quality. To guide forthcoming genome generation efforts and promote efficient prioritization of resources, it is thus essential to define and monitor taxonomic coverage and quality of the data.

Findings
Here we present an automated analysis workflow that surveys genome assemblies from the United States NCBI, assesses their completeness using the relevant BUSCO datasets, and collates the results into an interactively browsable resource. We apply our workflow to produce a community resource of available assemblies from the phylum Arthropoda, the Arthropoda Assembly Assessment Catalogue. Using this resource, we survey current taxonomic coverage and assembly quality at the NCBI, examine how key assembly metrics relate to gene content completeness, and compare results from using different BUSCO lineage datasets.

Conclusions
These results demonstrate how the workflow can be used to build a community resource that enables large-scale assessments to survey species coverage and data quality of available genome assemblies, and to guide prioritizations for ongoing and future sampling, sequencing, and genome generation initiatives.