bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paramutation-like Epigenetic Conversion by piRNA at the Telomere of Drosophila virilis
Authors: Dorador Ana P. , Dalikova Martina , Cerbin Stefan , Stillman Chris M. , Zych Molly G. , Hawley R. Scott , Miller Danny E. , Ray David A. , Funikov Sergei Y. , Evgen’ev Michael B. , Blumenstiel Justin P. 
Published: October 2022

First discovered in maize, paramutation is a phenomenon in which one allele can trigger an epigenetic conversion of an alternate allele. This conversion causes a genetically heterozygous individual to transmit alleles that are functionally the same, in apparent violation of Mendelian segregation. Studies over the past several decades have revealed a strong connection between mechanisms of genome defense against transposable elements by small RNA and the phenomenon of paramutation. For example, a system of paramutation in Drosophila melanogaster has been shown to be mediated by piRNAs, whose primary function is to silence transposable elements in the germline. In this paper, we characterize a second system of piRNA-mediated paramutation-like behavior at the telomere of Drosophila virilis. In Drosophila, telomeres are maintained by arrays of retrotransposons that are regulated by piRNAs. As a result, the telomere and sub-telomeric regions of the chromosome have unique regulatory and chromatin properties. Previous studies have shown that maternally deposited piRNAs derived from a sub-telomeric piRNA cluster can silence the sub-telomeric center divider gene of Drosophila virilis in trans. In this paper, we show that this silencing can also be maintained in the absence of the original silencing allele in a subsequent generation. The precise mechanism of this paramutation-like behavior may be explained by either the production of retrotransposon piRNAs that differ across strains or structural differences in the telomere. Altogether, these results show that the capacity for piRNAs to mediate paramutation in trans may depend on the local chromatin environment and proximity to the uniquely structured telomere regulated by piRNAs. This system promises to provide significant insights into the mechanisms of paramutation.
Autotoxicity of Endogenous Organic Acid Stress in Two Ganoderma lucidum Cultivars
Authors: Zou Pan , Guo Yongze , Ding Shu , Song Zhaowei , Cui Hanyuan , Zhang Yue , Zhang Zhijun , Chen Xiaoming 
Published: October 2022

Ganoderma lucidum has been used as a rare medical mushroom for centuries in China, due to its health-promoting properties. Successive cropping obstacles are common in the cultivation of G. lucidum, although the remaining nutrients in the germ substrate are sufficient for a second fruiting. Here, we aimed to study the metabolite profile of G. lucidum via nontargeted metabonomic technology. Metabonomic data revealed that organic acids played an important role in the cropping obstacles of G. lucidum, which is accordance with the pH decrease in the germ substrate. A Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis indicated that most differential acids participated in the metabolic pathways. Five acids were all significantly upregulated by two MS with high energy (MSE) modes in two cultivars, among which 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylic acid is also involved in purine metabolism regulation and microbial metabolism in diverse environments. Taken together, this work illustrated the organic acid stress generated by G. lucidum, which formed the autotoxicity feedback, and resulted in cropping obstacles. Determining the cause of the cropping obstacles in G. lucidum will promote the utilization rate of fungus substrate to realize the sustainable use of this resource.
A qualitative interview study of GPs’ experiences of prescribing opioid medication for chronic pain
Authors: Gill Simon , Bailey John , Nafees Sadia , Poole Rob 
Published: October 2022

BackgroundPrescribing of opioid medication has increased over the past 20 years. Most occurs in primary care for chronic pain. There is little evidence that these drugs are effective for this indication. There are concerns about the continuing prescribing of opioids, particularly in the long term and at high doses.AimTo explore GPs’ experiences of prescribing opioids, problems encountered, and factors militating against good prescribing practice.Design & settingQualitative interviews with GPs who prescribe opioids in primary care in North East Wales.MethodSemi-structured interviews with 20 GPs were transcribed and subjected to thematic analysis utilising the framework approach.ResultsParticipating GPs identified a range of problems associated with prescribed opioids. They were concerned about limited effectiveness of the drugs and what they perceived as addiction resulting from their use. They identified healthcare system factors that were obstacles to good prescribing practice such as lack of continuity of care, poor access to secondary care pain management support, and, most importantly, constant time pressure. They reported adverse effects on relationships with patients. Unrealistic expectations that pain could be eliminated resulted in pressure to prescribe stronger drugs and increased doses. It led to difficulties in establishing and maintaining trust and in persuading patients to agree to, and to carry out, dose reductions.ConclusionThemes emerging from this study suggest that GPs lack appropriate control of opioid prescribing. There is a need to develop methods to help patients and GPs to work together to manage chronic pain safely.
Gender and age concordance between patient and GP: an observational study on associations with referral behaviour
Authors: Eggermont Dorus , Kunst Anton E , Hek Karin , Verheij Robert A 
Published: October 2022

BackgroundAppropriate referral from primary to secondary care is essential for maintaining a healthcare system that is accessible and cost-effective. Social concordance can affect the doctor–patient interaction and possibly also referral behaviour.AimTo investigate the association of gender concordance and age concordance on referral rates in primary care in The Netherlands.Design & settingElectronic health records data (n= 24 841) were used from 65 GPs in The Netherlands, containing referral information, which was combined with demographics of GPs and patients to investigate factors associated with referral likelihood.MethodHealth records covered 16 different symptoms and diagnoses, categorised as ‘gender sensitive’, ‘age sensitive’, ‘both age and gender sensitive’, or ‘neutral’ based on Delphi consensus. Multi-level logistic regressions were performed to calculate the associations of gender and age concordance with referral status.ResultsOverall, 16.8% of patients were referred to a medical specialist. The female–male dyad (GP–patient) was associated with a higher referral likelihood (odds ratio [OR] 1.14; 95% confidence interval [CI] = 1.02 to 1.27;P= 0.02) compared with the female–female dyad. Gender discordance was associated with a higher referral likelihood regarding consultations involving ‘gender-sensitive’ symptoms and diagnoses (OR 1.21; CI = 1.02 to 1.44;P= 0.03), and in duo and group practices (OR 1.08; 95% CI = 1.00 to 1.16;P= 0.05). Age concordance was not a significant predictor of referrals in the main model nor in subgroup analyses.ConclusionGender discordance was associated with a higher likelihood of referring. This study adds to the evidence that gender concordance affects decisions to refer, particularly with respect to symptoms and diagnoses that can be regarded as ‘gender sensitive’.
PENGARUH UKURAN PERUSAHAAN, KEBIJAKAN HUTANG, PROFITABILITAS TERHADAP NILAI PERUSAHAAN (STUDI KASUS PERUSAHAAN PROPERTI YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2016 – 2020)
Authors: Kalbuana Nawang , Yohana Yohana , Bp Andi Intan , Cahyadi Catra Indra 
Published: October 2022

Penelitian ini bertujuan untuk menguji pengaruh Ukuran Perusahaan, Kebijakan Hutang, dan Profitabilitas terhadap Nilai Perusahaan pada Perusahaan Properti yang terdaftar di Bursa Efek Indonesia periode 2016-2020. Populasi dalam penelitian ini adalah sektor Perdagangan yang terdaftar di BEI. Teknik pemilihan sampel yang digunakan yaitu purposive sampling dengan beberapa kriteria yang telah ditentukan maka data sampel yang diperoleh 18 perusahaan dengan periode 2016-2020. Metode analisis data yang digunakan yaitu SPSS versi 25 dengan teknik analisis data yang digunakan adalah uji asumsi klasik multikolinieritas heteroskedastisitas, uji normalitas, uji koefisien korelasi dan determinasi, uji simultan dan uji parsial. Hasil penelitian menunjukkan bahwa ukuran perusahaan berpengaruh negatif signifikan terhadap nilai perusahaan, kebijakan hutang berpengaruh negatif signifikan terhadap nilai perusahaan, dan profitabilitas berpengaruh positif terhadap nilai perusahaan.
Flipped classroom y aprendizaje de las funciones trigonométricas en estudiantes de educación básica
Authors: Usho-Cisneros José Mauricio , Mena-Clerque Sandra Elizabeth 
Published: October 2022

La comprensión de los contenidos matemáticos constituye siempre un problema en el proceso educativo luego de esta pandemia esta penosa realidad se acrecentó, el presente trabajo investigativo tiene como objetivo la aplicación de la metodología Flipped Classroom para mejorar el aprendizaje de las Funciones Trigonométricas, en los estudiantes del 10mo año paralelo “B” del colegio de bachillerato “26 de noviembre” y su utilización en la resolución de ejercicios, la metodología que se aplico es te tipo cuasi experimental de corte longitudinal, mediante la aplicación de un cuestionario con los datos recopilados se pudo evidenciar que pese a que hemos trabajado de forma virtual durante la pandemia el 64% de las personas encuestadas conoce poco de flipped classroom se evidencia una despreocupación total por parte de los educandos lo que nos permite sugerir que es necesaria la aplicación de una metodología que involucre de manera eficiente y protagónica a los jóvenes para asimilar de mejor manera los conocimientos.
CMGAN: Conformer-Based Metric-GAN for Monaural Speech Enhancement
Authors: Abdulatif Sherif , Cao Ruizhe , Yang Bin 
Published: October 2022

<p>Convolution-augmented transformers (Conformers) are recently proposed in various speech-domain applications, such as automatic speech recognition (ASR) and speech separation, as they can capture both local and global dependencies. In this paper, we propose a conformer-based metric generative adversarial network (CMGAN) for speech enhancement (SE) in the time-frequency (TF) domain. The generator encodes the magnitude and complex spectrogram information using two-stage conformer blocks to model both time and frequency dependencies. The decoder then decouples the estimation into a magnitude mask decoder branch to filter out unwanted distortions and a complex refinement branch to further improve the magnitude estimation and implicitly enhance the phase information. Additionally, we include a metric discriminator to alleviate metric mismatch by optimizing the generator with respect to a corresponding evaluation score. Objective and subjective evaluations illustrate that CMGAN is able to show superior performance compared to state-of-the-art methods in three speech enhancement tasks (denoising, dereverberation and super-resolution). For instance, quantitative denoising analysis on Voice Bank+DEMAND dataset indicates that CMGAN outperforms various previous models with a margin, i.e., PESQ of 3.41 and SSNR of 11.10 dB. </p>
Comparison of One vs. Two Burr Hole Craniostomy in Chronic Subdural Hematoma Recurrence
Authors: Mahboob Khan  , Abdul Aziz Khan  , Sohail Ahmad  , Amir Zaman  , Khalid Khan  , Khalid Zardan  , Muhammad Irfanudin Khan  
Published: October 2022

Introduction/Objective: Chronic subdural hematoma (CSDH) is most frequent neurosurgical conditions. To find the recurrence rate of chronic subdural hematoma in patients who underwent one vs. two burr craniostomy.
Material And Methods: A randomized controlled trial was conducted at the Neurosurgery department, Ayub Teaching Hospital, Abbottabad. In the current study, a total of 76 (38 in each group) patients were observed. ASA-I, ASA-II, ASA III patients, symptomatic radiologically proven Chronic subdural hematoma. Patients were randomly allocated into two groups of 38 patients each. randomization with blocks. Group A was treated with intraoperative epidural methylprednisolone while Group B was treated with normal saline only. Clinical information was recorded on a pre-designed proforma.
Results: Mean age was 54 years in group A, and 56 years in group B. In group A, 74% were male and 26% of patients were female. In Group B, 76% were male and 24% were female. The group A, 5% of patients had recurrence while in Group B, 13% of patients had a recurrence. There existed a significant difference between effectiveness and not-effectiveness of one/two burr hole craniostomy among patients who were less than 40 years.
Conclusion: The recurrence rate of chronic subdural hematoma is higher in patients undergoing two burr hole craniostomy as compared to one burr craniostomy.
ANALISISA AKTIVITAS MANAJEMEN KONSTRUKSI PADA PROYEK LABORATORIUM BAHASA DAN KOMPUTER SMP NEGERI 1 BESUKI
Authors: Lutfan Anas Zahir  , Danang Hadi Nugroho  
Published: October 2022

Abstract
Managementㅤinㅤaㅤworkㅤjobㅤisㅤveryㅤimportantㅤtoㅤconsiderㅤinㅤtheㅤfieldㅤofㅤworkㅤcurrently growingㅤ rapidly.ㅤ Constructionㅤ managementㅤ isㅤ anㅤ organizationㅤ orㅤ individualㅤ thatㅤ isㅤ multi-disciplinary.ㅤConstructionㅤManagementㅤcanㅤconsistㅤofㅤbusinessㅤentitiesㅤthatㅤrequireㅤhumanㅤresourcesㅤwhoㅤareㅤexpertsㅤinㅤtheirㅤrespectiveㅤfieldsㅤwhoㅤneedㅤaㅤPOACㅤ(Planning,ㅤOrganizing,ㅤㅤ Actuating,ㅤandㅤ Controlling)ㅤ byㅤ beingㅤ systematicㅤ andㅤ measurable.
Atㅤpresentㅤ theㅤJuniorㅤ Highㅤ Schoolㅤ1 BesukiㅤinㅤCentralㅤJavaㅤisㅤunderwayㅤinㅤtheㅤLanguageㅤ Laboratoryㅤ Projectㅤ locatedㅤ inㅤ theㅤ southernㅤ partㅤ ofㅤ School.ㅤ Theㅤ researchㅤ methodㅤ usedㅤ inㅤ thisㅤ researchㅤ isㅤ literatureㅤ reviewㅤ fromㅤ variousㅤ sourcesㅤ thatㅤ discuss.ㅤ Dataㅤ obtainedㅤ fromㅤ fillingㅤ outㅤ questionnairesㅤ ㅤ byㅤ ㅤ respondentsㅤ ㅤ involvedㅤ ㅤ inㅤ ㅤ theㅤ ㅤ Schoolㅤ Languageㅤ Laboratoryㅤ Project.ㅤ Theㅤ questionnaireㅤ usedㅤ wasㅤ 15ㅤ respondentsㅤ whoㅤ answeredㅤ theㅤ questionnaire.
Theㅤresultsㅤofㅤtheㅤanalysisㅤofㅤtheㅤworkㅤmanagementㅤsystemㅤconstructionㅤfactorsㅤinㅤ ㅤ theㅤ Juniorㅤ Highㅤ Schoolㅤ Languageㅤ Laboratoryㅤ Projectㅤ ㅤ constructionㅤ ㅤ projectㅤ ㅤ areㅤ theㅤ mostㅤ ㅤ dominantㅤ ㅤ atㅤ theㅤ stageㅤ ofㅤ actuating,ㅤ ㅤ whileㅤ theㅤ analysisㅤ ㅤ ofㅤ theㅤ actionsㅤ takenㅤ byㅤ constructionㅤ ㅤ managementㅤ ㅤ toㅤ controlㅤ time,ㅤ cost,ㅤ andㅤ qualityㅤ isㅤ theㅤ mostㅤ dominantㅤ stageㅤ controlling.
Keywords: Analysis, Construction Management, POAC, Development, Efficiency
Abstrak
Manajemenㅤ dalamㅤmengelolaㅤsuatuㅤkegiatanㅤpekerjaanㅤkonstruksiㅤsangatㅤ ㅤ ㅤ diperlukanㅤ mengingatㅤ ㅤ usahaㅤ ㅤ diㅤ bidangㅤ ㅤ konstruksiㅤ ㅤ saatㅤ ㅤ iniㅤ semakinㅤ ㅤ berkembangㅤ ㅤ pesat.ㅤ ㅤ Manajemenㅤ ㅤ konstruksiㅤ merupakanㅤ ㅤ suatuㅤ ㅤ organisasiㅤ ㅤ atauㅤ peroranganㅤ ㅤ yangㅤ ㅤ bersifatㅤ ㅤ multiㅤ ㅤ disiplin.ㅤ ㅤ Manajemenㅤ ㅤ Konstruksiㅤ dapatㅤ berupa badanㅤ usahaㅤ yangㅤ didalamnyaㅤ diperlukanㅤ sumberㅤ dayaㅤ manusiaㅤ yangㅤ ahliㅤ dibidangnyaㅤ masing-masingㅤ yangㅤ mencakupㅤ POACㅤ (Planning,ㅤ Organizing,ㅤ Actuating,ㅤ danㅤ Controling)ㅤ secaraㅤ sistimatisㅤ danㅤ terukur.
Saatㅤ iniㅤ SMPㅤ Negeriㅤ 1ㅤ Bandungㅤ ㅤ sedangㅤ dilakukanㅤ proyekㅤ laboratoriumㅤ Komputerㅤ danㅤ Bahasaㅤ letaknyaㅤ ㅤ diㅤ centerㅤ bangunanㅤ sekolah.ㅤMetodeㅤpenelitianㅤ ㅤ yang digunakanㅤ ㅤ dalamㅤ dalamㅤ penelitianㅤ ㅤ iniㅤ adalahㅤ denganㅤ kajianㅤ pustakaㅤ dariㅤ berbagaiㅤsumberㅤ yangㅤ berkaitan.ㅤDataㅤ yangㅤ didapatkanㅤ ㅤ berasalㅤ ㅤ dariㅤ ㅤ pengisian ㅤ kuisionerㅤolehㅤ respondenㅤ yangㅤterlibatㅤdalamㅤproyekㅤLaboratoriumㅤ Bahasaㅤ danㅤ Komputer.ㅤ Kuisionerㅤyangㅤ digunakanㅤ sebanyakㅤ 15ㅤ respondenㅤ yangㅤ berpartisipasiㅤ dalamㅤ pengisianㅤ kuesioner.
Hasilㅤ analisisㅤ mengenaiㅤ faktorㅤ faktorㅤ sistemㅤ kerjaㅤ manajemenㅤ konstruksiㅤ padaㅤ proyekㅤ pembangunanㅤGedungㅤlaboratoriumㅤ KomputerㅤdanㅤBahasaㅤyangㅤpalingㅤdominanㅤadalahㅤpadaㅤ tahapanㅤpelaksanaan,ㅤsedangkanㅤanalisisㅤmengenaiㅤtindakan-tindakanㅤyangㅤdilakukanㅤmanajemenㅤkonstruksiㅤuntukㅤpengendalianㅤwaktu,ㅤbiaya,ㅤdanㅤmutuㅤyangㅤpalingㅤ ㅤ dominanㅤadalahㅤtahapanㅤpengendalian
Kata kunci: Analisis, Manajemen Konstruksi, POAC, Development, Efisiensi
The Optimatization of Kissing Gourami (Helostoma temminckii) Fry Density in Recirculation System Culture
Authors: Tansuka M , Taqwa Ferdinand H , Mukti Retno C 
Published: October 2022

Kissing gourami (Helostoma temminckii) is a type of swamp fish that has the potential to be cultivated. The increasing of yield for this fish can be done by optimization of stocking density. The problem of aquaculture with high stocking density is decreased water quality, growth and fish survival. One of the efforts to overcome this problem is through the management of the cultivation environment using a recirculation system. The purpose of this study was to determine the optimal density of kissing gourami fry on a recirculation system. This research method used a completely randomized design (CRD) using 4 treatments of fish stocking density (2, 3, 4, and 5 fish/L, respectively), which was carried out with 3 replications. The parameters observed included water quality, growth, survival rate, and fish blood glucose level. The results of this study indicated that the best density was 2 fish/L with absolute weight growth was 0.55 ± 0.03 g, absolute length growth was 0.53 ± 0.05 cm, survival rate was 86.67 %, blood glucose levels were 50.67−52.56 mg/dL and food conversion ratio was 1.29. The water quality value during the fish rearing was in the appropriate range, i.e. temperature 28.4−30.4°C, pH 6.6−7.4, dissolved oxygen 5.08−6.54 mg/L and ammonia 0.12−0.25 mg/L.
Re-utilization of Sub-optimal Used-planting Media to Cultivate Black Rice in the Pot
Authors: Halimi ES , Lestari MN , Syakirin C , Pales I 
Published: October 2022

Beside reducing production cost, re-utilization sub-optimal used planting media was environmentally good practice, especially when the plants were cultivated in the pots. This research incorporated black rice accession that had high economic value. The plants were cultivated in 10-kg pots, arranging in Randomized Block Design with three replications, each consisted of 5 pots. The treatments were weight-based additions of local organic soil and commercial organic fertilizer of 5 %, 10 %, 15 %, and 0 % (no-addition). Result of this research indicated that 10 % addition of local organic soil was considered enough to cultivated black rice in the pots. The plants were observed to grow normal with plant height reached 150 cm, consisted of 70 clumps and produced 56.52 g dry seeds per pot, equivalent to 11.69 ton per ha. In percentage, addition of 5, 10 and 15 % local organic soil, resulted in 33-53 % increase in number of mature panicles, 33-56 % increase in total number of seeds, 123-232 % increase in number pithy seeds, and 106-289 % increase in weight of dry seeds per pot.
Meningkatkan Kompetensi Pedagogik Pendidik dan Kepala Sekolah dalam Implementasi Kurikulum 13 di PAUD Merah Delima Jakarta Utara
Authors: Hasnah Hasnah 
Published: October 2022

Penelitian ini merupakan Penelitian Tindakan Sekolah yang dilakukan oleh Penilik PAUD di wilayah Kecamatan Kelapa Gading Jakrta Utara. Tujuan penelitian ini adalah untuk mengetahui efektivitas peningkatan Kompetensi Pedagogik Pendidik dan Kepala Sekolah Dalam Implementasi Kurikulum 13. Pada Penelitian ini menggunakan Teknik survei. Penelitian dilakukan dalam tiga tahapan, yaitu persiapan, pelaksanaan, evaluasi dan refleksi yang dilakukan minimal dalam dua siklus. Pada tahap persiapan dibuat dibuat skenario kegiatan, jadwal, waktu, tempat serta sarana pendukung lainnya seperti lembar observasi, serta angket. Dari hasil penelitian diperoleh data hasil penelitian dalam kegiatan penelitian tindakan sekolah ini dilakukan 2 siklus, bahwa supervisi akademik yang dilakukan oleh kepala sekolah dibantu Penilik PAUD terhadap 5 orang guru yang tidak memiliki latar belakang pendidikan keguruan tersebut, berhasil meningkatkan kompetensi pedagogik mereka dalam menyusun Perencanaan Pembelajaran dalam meningkatkan implementasi Kurikulum 13. Kemampuan pedagogik dapat dilakukan secara rutin sehingga guru PAUD dapat terus meningkatkan kemampuan mengajar peserta didik secara kreatif dan inovatif dan juga dapat dilakukan terhadap semua guru secara bergilir dan menyangkut seluruh aspek kemampuan dan kompetensi guru seperti yang disyaratkan dalam Permendiknas No 16 tahun 2007.
The Influence of Product Innovation, Environmental Strategy and Circular Economy On Sustainable Development in Organizations in Northeastern Brazil
Authors: Severo Eliana Andréa , De Guimarães Julio Cesar Ferro 
Published: October 2022

Objective: Analyze the influences of the relationships between product innovation, environmental strategy and circular economy on sustainable development in organizations in the Northeast of Brazil.
Method: The method used was quantitative and descriptive research, through a survey, using the snowball method, applied to 557 companies in the Northeast of Brazil, through the elaboration of three research hypotheses. For data analysis, statistical tests, confirmatory factor analysis, and multiple linear regression were used.
Results: Based on the analysis of the three models in the multiple linear regression, an explanation index greater than 37% (R2) is evidenced, that is, the influence relationships present a moderate intensity, where product innovation, environmental strategy) and the circular economy positively influences sustainable development in organizations in the Northeast of Brazil.
Conclusions: The Model that had the greatest influence on Sustainable Development was Model 3, with a moderate intensity of influence (46.20%), that is, the relationship between the circular economy and sustainable development. In this context, it is worth mentioning that natural resources are finite, and the world population is growing exponentially, which demands new products, food, housing, health, education, employment, and income, indicating that organizations must reduce the consumption of natural resources and the impact on the environment, where environmental strategy and circular economy can effectively contribute to sustainable development.