bluuebunny/crossref_metadata_2025_split huggingface dataset:
ISLAM, NEGARA, DAN CIVIL SOCIETY: ANALISIS WACANA KRITIS PADA ARTIKEL COVID-19 DI REPUBLIKA
Authors: Iskandar Dudi 
Published: May 2022

Pandemik virus corona atau covid-19 telah menyita perhatian dunia. Di Indonesia, penderita covid-19 pertama terditeksi Maret 2020. Pemerintah segera bertindak cepat dengan membentuk gugus tugas covid-19 untuk mengatasi pandemik covid-19 tersebut. Dari perspektif media, pandemik covid-19 memiliki semua persyaratan untuk menjadi isi media. Ia memiliki semua nilai berita. Makanya secara teoritis pandemik covid-19 layak menghiasinya semua bagian media, termasuk rubrik opini di media cetak. Fokus penelitian ini adalah wacana yang ada di rubrik opini Republika selama satu bulan, Maret 2020, yakni, 23 tulisan. Pendekatan penelitian yang digunakan adalah kualitatif dengan metode penelitian analisis wacana kritis. Penelitian ini menemukan, pertama, wacana covid-19 yang ada di edisi Maret 2020 di Republika terasa kurang greget. Hanya sebatas deskripsi. Kerangka Islam yang dipakai adalah Islam moderat yang cair, bukan pisau analisis Islam kiri atau Islam postmodern yang kritis dan radikal dalam membedah satu masalah atau kebijakan negara. Dari perspektif civil society, wacana covid-19 edisi Maret 2020 di Republika, secara teoritikal hanya sebatas bagian dari negara bukan kritik atau kontrol terhadap kebijakan negara. Wacana yang lemah lembut tanpa kritik dan hentakan kepada kebijakan negara ini dimungkinkan karena posisi Republika yang merupakan bagian dari kekuasaan melalui sosok pemilik saham terbesarnya Erick Thohir.
ANALYSIS OF EARTHQUAKE-PRONE AREAS FOR DISASTER MITIGATION IN THE SUMATRA TRENCH AND SURROUNDINGS
Authors: Sinaga Rosiyanti , Ronoatmojo Imam Setiaji 
Published: May 2022

Indonesia is situated at the junction of three active plates: Eurasia, Circum Pacific, and Indo-Australia.. Sumatran tectonics is controlled by the subduction of two plates, namely the Indo-Australian plate and the southeastern Eurasian plate. The research area is along the Sumatra Trench and the data used are from the United States Geological Survey in the last 50 years, the depth is 0-60 km, and the methodology used is the least squares method. Purpose of this study, to predict the occurrence of earthquakes with the aim of minimizing the impact of damage that occurs in earthquakes. The Locked Area has a high return period value, the influencing factor is the existence of a seismic gap, where the stress applied to this area will be isolated due to seamount subduction, so that it can withstand earthquakes. but one day, when the rock can no longer withstand the stress, it will cause an earthquake with large strength.
Factors Associated with Acceptability of Newborn Screening for Sickle Cell Disease in Lubumbashi City, Democratic Republic of the Congo
Authors: Katamea Tina , Mukuku Olivier , Mpoy Charles Wembonyama , Mutombo André Kabamba , Luboya Oscar Numbi , Wembonyama Stanislas Okitotsho 
Published: May 2022

Objective:
Sickle cell disease (SCD) is a major genetic disease that occurs early in childhood and can cause considerable morbidity and even death. Newborn screening (NBS) is one of the effective health services that have lowered the burden of SCD in wealthy countries. Surprisingly, NBS programs are essentially non-existent in subSaharan Africa, where the majority of babies are born with this condition. The objective of this study was to determine the level of acceptability of NBS and the factors influencing it in the population of Lubumbashi city in the Democratic Republic of the Congo.

Material and Methods:
From December 1, 2020, to December 31, 2020, data on sociodemographic characteristics, knowledge, and attitudes related to NBS for SCD were collected from 2032 adults in Lubumbashi city using a semi-structured and pre-tested questionnaire.

Results:
There was a good knowledge of SCD as a hereditary blood disorder (77.7%). NBS’s acceptability rate was 84.5%. Age (P = 0.002), sex (P = 0.025), and religion (p<0.001) were found to be significantly associated with the NBS acceptability.

Conclusion:
According to the findings of this study, NBS is widely accepted in Lubumbashi. The primary challenges to its adoption are likely to be financial and practical rather than social or cultural.
Strategic Environmental Policies in the Presence of Differentiated Goods
Authors: Espinosa Ramírez Rafael Salvador , Sandoval Salvador 
Published: May 2022

We develop a theoretical model of partial equilibrium where firms, located in a country, compete and produce differentiated goods in a duopolistic market. Emission of pollution is related to production, and firms produce their output using different levels of polluting technology. To control pollution emission, the government applies discriminatory pollution quotas considering the benefits for firms, consumers, and environmental damage. The results show that if the disutility to be polluted is very high, the government imposes a zero-emission quota on the companies. But, if such disutility is not significantly high, it allows a certain amount of emissions, imposing different quotas on firms depending on the levels of technology they use to control their emissions. The proposed model stresses the importance of the rational establishment of strategic environmental policies, which benefit all economic agents in the market, firms, consumers, and the environment.

Resumen
Desarrollamos un modelo teórico de equilibrio parcial donde las empresas, ubicadas en un país, compiten y producen bienes diferenciados en un mercado duopolístico. La emisión de contaminación está relacionada con la producción, y las empresas producen utilizando diferentes niveles de tecnología contaminante. Para controlar la emisión de contaminación, el gobierno aplica cuotas de contaminación discriminatorias teniendo en cuenta el beneficio para las empresas, los consumidores y el daño ambiental. Los resultados muestran que si la desutilidad a contaminar es muy alta, el gobierno impone una cuota de cero emisiones a las empresas. Pero, si dicha desutilidad no es significativamente alta, permite una cierta cantidad de emisiones, imponiendo diferentes cuotas a las empresas dependiendo de los niveles de tecnología que utilizan para controlar sus emisiones. El modelo propuesto subraya la importancia del establecimiento racional de políticas ambientales estratégicas, que actúen en beneficio de todos los agentes económicos en el mercado, las empresas, los consumidores y el medio ambiente.
Pengaruh Metode Inquiry Training terhadap Sikap Sosial Siswa SD Pada Mata Pelajaran IPS
Authors: Arisandy M , Nurhasanah Nurhasanah , Jaelani Abdul Kadir 
Published: May 2022

Sikap sosial yang baik adalah hal yang sangat fundamental bagi peserta didik selain kemampuan intelektual dan keterampilan. Untuk menumbuhkan sikap sosial siswa dengan efektif, guru perlu menerapkan metode pembelajaran yang sesuai. Tujuan dari penelitian ini adalah untuk mengetahui adanya pengaruh metode Inquiry Training terhadap sikap sosial siswa. Populasi pada penelitian ini berjumlah 36 siswa, sedangkan jumlah sampel penelitian yaitu 36 siswa dari dua kelas berbeda sebagai kelas kontrol dan kelas eksperimen yang dihasilkan melalui teknik simple random sampling. Penelitian ini merupakan penelitian Quasi Eksperimen tipe Nonequivalent Control Group Design. Instrumen penelitian ini menggunakan angket dengan skala likert yang telah memenuhi persyaratan uji instrumen penelitian. Hipotesis diuji menggunakan uji ANOVA satu jalan pada signifikansi 5% dan diperoleh hasil > (4,13) yang artinya ada perbedaan antara kelas kontrol dan kelas eksperimen. Perolehan skor rata-rata pada kelas eksperimen yang menggunakan metode Inquiry Training meliputi indikator rasa ingin tahu sebesar 46, indikator tanggung jawab sebesar 29, indikator percaya diri sebesar 38, dan indikator jujur sebesar 18. Hasil tersebut lebih tinggi dibandingkan dengan rata-rata kelas kontrol yang meliputi indikator rasa ingin tahu sebesar 40, indikator tanggung jawab sebesar 25, indikator percaya diri sebesar 33, dan indikator jujur sebesar 17. Sehingga disimpulkan bahwa ada pengaruh metode Inquiry Training terhadap sikap sosial siswa.
Pengaruh Model Pembelajaran Problem Based Learning (PBL) terhadap Kemampuan Berpikir Kritis Siswa Pada Pembelajaran IPA Kelas IV SDN 1 Beleka Tahun 2021/2022
Authors: Mariskhantari Melya , Karma I Nyoman , Nisa Khairun 
Published: May 2022

Pendidikan adalah usaha agar manusia mengembangkan potensi dirinya melalui proses belajar di sekolah. Perlu adanya variasi mengajar yang berbeda dalam proses pembelajaran agar siswa lebih aktif, antusias dan senang dalam belajar, seperti menggunakan model pembelajaran Problem based Learning. Problem Based Learning adalah sebuah model pembelajaran kontekstual menggunakan masalah sebagai fokus utama pembelajaran. Model Problem Based Learning menjadi model pembelajaran yang mampu mengasah berpikir kritis siswa. Tujuan penelitian ini untuk mengetahui pengaruh Model Pembelajaran Problem Based Learning terhadap kemampuan berpikir kritis siswa pada pembelajaran IPA siswa kelas IV SDN 1 Beleka tahun ajaran 2021/2022. Metode penelitian ini dalah metode kuantitatif. Jenis penelitian ini adalah Quasi Experimental Design serta populasi penelitian ini ialah 81 siswa yang terdiri dari kelompok eksperimen dan kelompok kontrol. Teknik pengumpulan data yang digunakan adalah observasi, tes dan dokumentasi. Adapun teknik analisis data menggunakan uji normalitas, uji homogenitas, uji hipotesis, dan uji effect size. Sedangkan untuk teknik penyajian data histogram dan Tabel. Hasil identifikasi pengaruh model pembelajaran problem based learning (PBL) terhadap kemampuan berpikir kritis siswa pada pembelajaran IPA kelas IV SDN 1 Beleka menunjukkan adanya pengaruh model pembelajaran problem based learning (PBL) terhadap kemampuan berpikir kritis siswa pada pembelajaran IPA kelas IV serta uji hipotesis dalam penelitian ini digunakan rumus independent sample t test. Hasil analisis data menunjukkan df=79, di peroleh hasil t hitung =3,122 > t Tabel, maka hipotesis (Ha) yang diajukan diterima. Maka dapat disimpulkan bahwa terdapat pengaruh model pembelajaran problem based learning (PBL) terhadap kemampuan berpikir kritis siswa pada pembelajaran IPA kelas IV SDN 1 Beleka tahun 2021/2022.
MARITIME CRYPTOLOGY
Authors: Alamsyah Intan Muchtadi 
Published: May 2022

Maritime has special needs for information security, including the protection of classified information. As written in â€œCryptographyâ€™s Role in Securing the Information Societyâ€: â€˜Cryptography provides important capabilities that can help deal with the vulnerabilities of electronic information. Cryptography can help to assure the integrity of data, to authenticate the identity of specific parties, to prevent individuals from plausibly denying that they have signed something, and to preserve the confidentiality of information that may have improperly come into the possession of unauthorized parties [Dam and Lin, 1996].
Elliptic Curve Cryptography (ECC) was first introduced by Neal Koblitz and Victor Miller ([Koblitz1987],[Miller1985]). They independently introduced the elliptic curve to design a public-key cryptography. Compared to other cryptography method, it has several advantages: its arithmetic operations are spesific and can not be predicted, it offers smaller key length for the same security level compared to other method and its operations have many layers and combinations. ECC relies on the security level of the discrete logarithm problem called Elliptic Curve Discrete Logarithm Problem (ECDLP) [Hankerson et al, 2004].
INHIBITORY TEST ANTIMICROBIAL OF SEAWEED EXTRACT FROM Padina sp. AGAINST THE GROWTH OF Vibrio parahaemolyticus, Staphylococcus aureus, Escherichia coli AND Salmonella thypimirium
Authors: Kolanus Joice P. M. , Dompeipen Edward J. 
Published: May 2022

The content of secondary metabolites of seaweed as an antibacterial, antiviral, antifungal and sitotastik have great potential as a source of cure various diseases. Padina sp is one of brown algae which is potential to be a natural antibacterial agent. This research aims to determine the inhibitory potency of Padina sp. extract on the growth of Vibrio parahaemolyticus, Staphylococcus aureus, Escherichia coli, and Salmonella thypimirium bacterial. The extraction Padina sp using methanol as the solvent while the treated samples dilution of 0, 5, 10 and 50. Then measuring the inhibition by paper disc methods. Result showed that the diameter methanol extract of seaweed Padina sp. against bacterial the growth inhibition of E. coli each 26.5 mm with the very strong barriers response and 17.5 mm were classified as strong; on the growth of Salmonella thypimirium bacteria by 19 mm with a response barriers that were moderate but not have inhibitory effect on the growth of Vibrio parahaemolyticus and Staphylococcus aureus bacterial.
STUDY OF BENTONITE ACTIVATION USING SULFURIC ACID AND ITS APPLICATION AS AN ADSORBENT OF RHODAMINE B DYE
Authors: Bijang Catherina M. , Sri Dewi 
Published: May 2022

A study about activated bentonite with 2M, 3M, 4M Sulfuric Acid and its application as a Rhodamin dye adsorbent had been done. Bentonite was saturated with 3M NaCl before activated by acid. Performance determination of adsorbent is done by using Uv-Vis Spectrophotometric method. Concentrate determination of Rhodamin B dye made at a wavelength of 554 nm. The result obtained showed that the 2M sulfuric acid bentonite is the best adsorbent.
THE USE AS BIO-INDICATORS SPONGE Callispongia sp. HEAVY METALS CD METAL CONTAMINATION IN THE WATERS OF THE AMBON BAY
Authors: Siahaya A. N. , Noor Alfian , De Voogd Nicole 
Published: May 2022

The deposition of heavy metals in Ambon Bay was investigated by using sponge species (Callispongia sp.) as bioindicator. Two different sampling schemes are discussed in this paper: a random sampling scheme with 8 sampling sites distributed over the whole territory of Ambon Bay. Unwashed, dried samples were totally the concentrations of metal elements were determined by inductively coupled plasma atomic emission spectroscopy (ICP-AES). Heavy metal Cd. The median concentrations and statistical parameters of elements were discussed by comparing two sampling schemes. The results of both sampling schemes are compared with the results of other the location of the net. Different levels of the contamination valuated by the respective contamination factor (CF) of each element are obtained for both sampling schemes, while the local contamination identified like cadmium metallurgy and cement industry, oil refinery, mining industry, and transport have been the same for both sampling schemes. In addition, the natural sources, from the accumulation of these metals in sponge caused by metal-enriched soil, associated with activity in the land were pointed as another possibility of local factors.
Radical supramaximal resection for newly diagnosed left-sided eloquent glioblastoma: safety and improved survival over gross-total resection
Authors: Di Long , Shah Ashish H. , Mahavadi Anil , Eichberg Daniel G. , Reddy Raghuram , Sanjurjo Alexander D. , Morell Alexis A. , Lu Victor M. , Ampie Leonel , Luther Evan M. , Komotar Ricardo J. , Ivan Michael E. 
Published: May 2022

OBJECTIVE
Supramaximal resection (SMR) has arisen as a possible surrogate to gross-total resection (GTR) to improve survival in newly diagnosed glioblastoma (nGBM). However, SMR has traditionally been limited to noneloquent regions and its feasibility in eloquent nGBM remains unclear. The authors conducted a retrospective multivariate propensity-matched analysis comparing survival outcomes for patients with left-sided eloquent nGBM undergoing SMR versus GTR.

METHODS
A retrospective review was performed of all patients at our institution who underwent SMR or GTR of a left-sided eloquent nGBM during the period from 2011 to 2020. All patients underwent some form of preoperative or intraoperative functional mapping and underwent awake or asleep craniotomy (craniotomy under general anesthesia); however, awake craniotomy was performed in the majority of patients and the focus of the study was SMR achieved via awake craniotomy and functional mapping with lesionectomy and additional peritumoral fluid attenuated inversion recovery (FLAIR) resection. Propensity scores were generated controlling for age, tumor location, and preoperative Karnofsky Performance Status (KPS) score with the nearest-neighbor algorithm.

RESULTS
A total of 102 patients (48 SMR, 54 GTR) were included in this study. The median overall survival (OS) and progression-free survival (PFS) for patients receiving SMR were 22.9 and 5.1 months, respectively. Propensity matching resulted in a final cohort of 27 SMR versus 27 GTR patients. SMR conferred improved OS (21.55 vs 15.49 months, p = 0.0098) and PFS (4.51 vs 3.59 months, p = 0.041) compared to GTR. There was no significant difference in postoperative complication rates or KPS score in SMR compared with GTR patients (p = 0.236 and p = 0.736, respectively). In patients receiving SMR, improved OS and PFS showed a dose-dependent relationship with extent of FLAIR resection (EOFR) on log-rank test for trend (p < 0.001).

CONCLUSIONS
SMR by means of awake craniotomy with functional mapping for left-sided eloquent nGBM is safe and confers a survival benefit compared to GTR obtained with lesionectomy alone while preserving postoperative neurological integrity. When tolerated, greater EOFR with SMR may be associated with improved survival.
Adverse radiation effect and freedom from progression following repeat stereotactic radiosurgery for brain metastases
Authors: Sneed Penny K. , Chan Jason W. , Ma Lijun , Braunstein Steve E. , Theodosopoulos Philip V. , Fogh Shannon E. , Nakamura Jean L. , Boreta Lauren , Raleigh David R. , Ziemer Benjamin P. , Morin Olivier , Hervey-Jumper Shawn L. , McDermott Michael W. 
Published: May 2022

OBJECTIVE
The authors previously evaluated risk and time course of adverse radiation effects (AREs) following stereotactic radiosurgery (SRS) for brain metastases, excluding lesions treated after prior SRS. In the present analysis they focus specifically on single-fraction salvage SRS to brain metastases previously treated with SRS or hypofractionated SRS (HFSRS), evaluating freedom from progression (FFP) and the risk and time course of AREs.

METHODS
Brain metastases treated from September 1998 to May 2019 with single-fraction SRS after prior SRS or HFSRS were analyzed. Serial follow-up magnetic resonance imaging (MRI) and surgical pathology reports were reviewed to score local treatment failure and AREs. The Kaplan-Meier method was used to estimate FFP and risk of ARE measured from the date of repeat SRS with censoring at the last brain MRI.

RESULTS
A total of 229 retreated brain metastases in 124 patients were evaluable. The most common primary cancers were breast, lung, and melanoma. The median interval from prior SRS/HFSRS to repeat SRS was 15.4 months, the median prescription dose was 18 Gy, and the median duration of follow-up imaging was 14.5 months. At 1 year after repeat SRS, FFP was 80% and the risk of symptomatic ARE was 11%. The 1-year risk of imaging changes, including asymptomatic RE and symptomatic ARE, was 30%. Among lesions that demonstrated RE, the median time to onset was 6.7 months (IQR 4.7–9.9 months) and the median time to peak imaging changes was 10.1 months (IQR 5.6–13.6 months). Lesion size by quadratic mean diameter (QMD) showed similar results for QMDs ranging from 0.75 to 2.0 cm (1-year FFP 82%, 1-year risk of symptomatic ARE 11%). For QMD < 0.75 cm, the 1-year FFP was 86% and the 1-year risk of symptomatic ARE was only 2%. Outcomes were worse for QMDs 2.01–3.0 cm (1-year FFP 65%, 1-year risk of symptomatic ARE 24%). The risk of symptomatic ARE was not increased with tyrosine kinase inhibitors or immunotherapy before or after repeat SRS.

CONCLUSIONS
RE on imaging was common after repeat SRS (30% at 1 year), but the risk of a symptomatic ARE was much less (11% at 1 year). The results of repeat single-fraction SRS were good for brain metastases ≤ 2 cm. The authors recommend an interval ≥ 6 months from prior SRS and a prescription dose ≥ 18 Gy. Alternatives such as HFSRS, laser interstitial thermal therapy, or resection with adjuvant radiation should be considered for recurrent brain metastases > 2 cm.
Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats
Authors: Yamaguchi Tadashi , Miyamoto Takeshi , Shikata Eiji , Yamaguchi Izumi , Shimada Kenji , Yagi Kenji , Tada Yoshiteru , Korai Masaaki , Kitazato Keiko T. , Kanematsu Yasuhisa , Takagi Yasushi 
Published: May 2022

OBJECTIVE
Subarachnoid hemorrhage (SAH) due to intracranial aneurysm (IA) rupture is often a devastating event. Since the incidence of SAH increases especially in menopause, it is crucial to clarify the detailed pathogenesis of these events. The activation of vascular nucleotide-binding oligomerization domain–like receptor family pyrin domain–containing 3 (NLRP3) inflammasomes has been studied in ischemic stroke and cardiovascular disease. However, the role of NLRP3 in IA rupture still needs to be explained. The authors sought to test their hypothesis that, under estrogen-deficient conditions, activation of NLRP3 inflammasomes via downregulation of the estrogen receptor (ER) facilitates IA rupture.

METHODS
Ten-week-old female Sprague Dawley rats with and without oophorectomy were subjected to hemodynamic changes and hypertension (OVX+/HT and OVX−/HT, respectively) and fed a high-salt diet. Separately, using human brain endothelial cells (HBECs) and human brain smooth muscle cells (HBSMCs), the authors tested the effect of NLRP3 under estrogen-free conditions and in the presence of estradiol or of ER agonists.

RESULTS
In OVX+/HT rats, the frequency of IA rupture was significantly higher than in OVX−/HT rats (p = 0.03). In the left posterior cerebral artery prone to rupture in OVX+/HT rats, the levels of the mRNAs encoding ERα and Sirt1, but not of that encoding ERβ, were decreased, and the levels of the mRNAs encoding NLRP3, interleukin-1β (IL-1β), and matrix metalloproteinase 9 (MMP-9) were elevated. Immunohistochemical analysis demonstrated that the expression profiles of these proteins correlated with their mRNA levels. Treatment with an ER modulator, bazedoxifene, normalized the expression profiles of these proteins and improved SAH-free survival. In HBECs and HBSMCs under estrogen-free conditions, the depletion of ERα and Sirt1 and the accumulation of NLRP3 were counteracted by exposure to estradiol or to an ERα agonist but not to an ERβ agonist.

CONCLUSIONS
To the authors’ knowledge, this work represents the first demonstration that, in an aneurysm model under estrogen-deficient conditions, the depletion of ERα and Sirt1 may contribute to activation of the NLRP3/IL-1β/MMP-9 pathway, facilitating the rupture of IAs in the estrogen-deficient rat IA rupture model.