bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hysteroscopic Curettage Followed by Megestrol Acetate Plus Metformin as a Fertility-Sparing Treatment for Women with Atypical Endometrial Hyperplasia or Well-Differentiated Endometrioid Endometrial Carcinoma
Authors: Jing Chu-Yu , Li Sheng-Nan , Shan Bo-Er , Zhang Wei , Tian Wen-Juan , Ren Yu-Lan , Wang Hua-Ying 
Published: July 2022

Background: In reproductive-aged women, the incidence of atypical endometrial hyperplasia (AEH) or endometrioid endometrial carcinoma (EEC) is rising globally. The study aimed to investigate the effectiveness of hysteroscopic curettage followed by megestrol acetate (MA) plus metformin as conservative treatment in AEH and early EEC. Methods: We retrospectively studied AEH and stage IA, grade 1 EEC patients treated with hysteroscopic curettage followed by MA (160 mg/d) plus metformin (1500 mg/d) from January 2010 to December 2020 at Fudan University Shanghai Cancer Center. Treatment outcomes were assessed by complete response (CR) rate, recurrence rate, and pregnancy outcomes. Univariate and multivariate analyses were performed via the logistic regression model. Results: The study included 79 patients, 31 (39.2%) with AEH and 48 (60.8%) with EEC. The medians of age (years) and follow-up time (months) were 30 and 39.5, respectively. Seventy-six patients (96.2%) finally achieved CR. The median time to CR was 3.6 (3.0-20.6) months. The CR rate after 3 months, 6 months, and 1 year was 55 (69.6%), 67 (84.8%), and 72 (91.1%), respectively. Recurrence occurred in 26 (34.2%) patients. Treatment duration ⩾9 months was associated with a lower recurrence rate after CR ( P = .012). Fourteen (93.3%) of the 15 recurrent patients who received progestin re-treatment achieved CR again. Finally, 29 patients delivered live births. Conclusions: Hysteroscopy followed by MA plus metformin can achieve CR in short time and is overall safe. Consolidation treatment should be prolonged to decrease the recurrence rate, despite a shorter time to CR.
Pediatric Lymphedema: Study of 180 Patients Referred to a Tertiary Lymphedema Clinic
Authors: Colmant Caroline , Turpin Sophie , Lambert Raymond , Wong Nicole , Ondrejchak Sandra , Lapointe Chantal , Powell Julie , Dubois Josée , McCuaig Catherine 
Published: July 2022

BackgroundLymphedema is due to dysfunction of the lymphatic system. It can be primary or secondary. Pediatric lymphedema is more often primary and is a chronic disease with a heavy burden on quality of life.MethodsMedical records of patients under 18 years of age referred between 1996 and 2021 to the specialized lymphedema clinic at the Sainte-Justine University Hospital Center were reviewed. Demographic data, sex, age at presentation, location of the lymphedema, clinical features, genetic testing, symptoms, complications, investigations, and treatment were collected.ResultsOf 180 referred patients, lymphedema was confirmed in 151, and 137 were primary lymphedema. Median age of apparition of primary lymphedema was 7.00 years and was significantly lower in boys than in girls. Primary congenital lymphedema was more frequent in boys (51.0%, 27.3% in girls, P = .007), and onset of primary lymphedema during adolescence was more frequent in girls (53.4%, 25.0% in boys, P = .001). Lower limbs were the most impacted (88.3%). Sixty patients had genetic testing, and 38 (63.3%) of them were discovered to have a pertinent genetic mutation. The most common mutated gene was the FLT4 gene (in 9 patients). Seven patients (5.1%) had associated extensive/central lymphatic malformation and 24 (17.6%) had a polymalformative syndrome/syndromic lymphedema.ConclusionsPediatric lymphedema is more frequent in girls, usually involves lower limb, and is most often sporadic, but often associated with a genetic mutation, and genetic testing should be performed.
Synergetic effect of surface connectivity and functional parameters on the friction characteristics of a sliding contact interface
Authors: Ji Jiawei , Liu Xiaojun , Zhang Yan , Jiao Yunlong , Liu Kun 
Published: July 2022

The characteristics of surface morphology markedly affect the tribological properties of contact interface such as lubrication and seal performance. In present work, the synergetic effect of surface connectivity and some three-dimensional topography parameters (ISO 25178) on the friction characteristics of a sliding contact interface, based on mathematical morphology and reciprocating linear tribotesting, is explored. The results indicate that the friction properties of sliding contact interface was significantly affected by the variation of surface connectivity. The increase in connectivity index would improve the relative contact area on the isotropic surfaces and affect the distribution and storage characteristics of the fluid, while this enhancement would be blocked on the anisotropic surface and the variation of connectivity index is obviously nonlinear with a shocking feature. The friction tests confirm that the friction coefficient of sliding contact interface decreases with the increasing surface connectivity index, which is mainly related to the enhancement of lubricant storage and flow in each void region and improving the lubrication behavior. Furthermore, the same variation law is applicable to the relationship between the functional morphology parameters and the friction property. The increasing Vvv and Sku, would contribute to a lower friction coefficient at the interface. Our work provides deep insights into regulating the tribological property of contact interfaces through surface topography control.
‘As Long as It's Used for Beneficial Things’: An Investigation of non-Māori, Māori and Young People's Perceptions Regarding the Research use of the Aotearoa New Zealand Integrated Data Infrastructure (IDI)
Authors: Thabrew Hiran , Aljawahiri Noor , Kumar Harshali , Bowden Nicholas , Milne Barry , Prictor Megan , Jordan Vanessa , Breedvelt Josefein , Shepherd Toni , Hetrick Sarah 
Published: July 2022

The Aotearoa New Zealand Integrated Data Infrastructure (IDI) is a national database containing a wide range of data about people and households. There is limited information about public views regarding its use for research. A qualitative study was undertaken to examine the views of forty individuals attending a large hospital in Auckland, including those of Māori ethnicity and young people. Semi-structured interview data were analysed using Braun and Clarke's method of thematic analysis. Seven key themes emerged: 1) Limited knowledge about medical data held in national databases; 2) Conditional support for the use of the IDI, including for research; 3) Concerns regarding the misuse of IDI data; 4) The importance of privacy; 5) Different views regarding consent for use of data for research; 6) Desire for access to personal data and the results of research; and 7) Concerns regarding third party and commercial use. Young people and those of Māori ethnicity were more wary of data misuse than others. Although there is reasonable support for the secondary use of public administrative data in the IDI for research, there is more work to be done to ensure ethical and culturally appropriate use of this data via improved consent privacy management processes and researcher training.
Role of multi-parametric magnetic resonance imaging fusion biopsy in active surveillance of prostate cancer: a systematic review
Authors: Ellis Elizabeth E. , Frye Thomas P. 
Published: July 2022

Background: Our goal is to review current literature regarding the role of multi-parametric magnetic resonance imaging (mpMRI) in the active surveillance (AS) of prostate cancer (PCa) and identify trends in rate of reclassification of risk category, performance of fusion biopsy (FB) versus systematic biopsy (SB), and progression-free survival. Methods: We performed a comprehensive literature search in PubMed and identified 121 articles. A narrative summary was performed. Results: Thirty-two articles were chosen to be featured in this review. SB and FB are complementary in detecting higher-grade disease in follow-up. While FB was more likely than SB to detect clinically significant disease, FB missed 6.4–11% of clinically significant disease. Imaging factors that predicted upgrading include number of lesions on magnetic resonance imaging (MRI), lesion density, and MRI suspicion level. Conclusion: Incorporating mpMRI FB in conjunction with SB should be part of contemporary AS protocols. mpMRI should additionally be used routinely for follow-up; however, mpMRI is not currently sensitive enough in detecting disease progression to replace biopsy in the surveillance protocol.
Sign of the times: Community engagement to refine a cardiovascular mHealth intervention through a virtual focus group series during the COVID-19 Pandemic
Authors: Brewer LaPrincess C. , Cyriac Jissy , Kumbamu Ashok , Burke Lora E. , Jenkins Sarah , Hayes Sharonne N. , Jones Clarence , Cooper Lisa A. , Patten Christi A. 
Published: July 2022

Background African-Americans are underrepresented in mobile health intervention research studies which can perpetuate health inequities and the digital divide. A community-based, user-centered approach to designing mobile health interventions may increase their sociocultural relevance and effectiveness, especially with increased smartphone use during the coronavirus disease 2019 pandemic. We aimed to refine an existing mobile health intervention via a virtual focus group series. Methods African-American community members (n = 15) from churches in Minneapolis-St. Paul and Rochester, Minnesota were enrolled in a virtual (via videoconferencing), three-session focus group series over five months to refine a cardiovascular health-focused mobile health application (FAITH! [Fostering African-American Improvement in Total Health!] App). Participants accessed the app via their smartphones and received a Fitbit synced to the app. Participants engaged with multimedia cardiovascular health-focused education modules, a sharing board for social networking, and diet/physical activity self-monitoring. Participant feedback on app features prompted iterative revisions to the FAITH! App. Primary outcomes were app usability (assessed via Health Information Technology Usability Evaluation Scale range: 0–5) and user satisfaction. Results Participants (mean age [SD]: 56.9 [12.3] years, 86.7% female) attended a mean 2.8 focus groups (80% attended all sessions). The revised FAITH! App exceeded the goal Health Information Technology Usability Evaluation Scale score threshold of ≥4 (mean: 4.39, range: 3.20–4.95). Participants positively rated updated app content, visual appeal, and use of social incentives to maintain engagement. Increasing user control and refinement of the moderated sharing board were identified as areas for future improvement. Conclusions Community-partnered, virtual focus groups can optimize usability and increase participant satisfaction of mobile health lifestyle interventions that aim to promote cardiovascular health in African-Americans.
The Association Between Salivary FGF2 and Physiological and Psychological Components of the Human Stress Response
Authors: Bryant Emma M. , Richardson Rick , Graham Bronwyn M. 
Published: July 2022

Background Fibroblast Growth Factor 2 (FGF2) is a neurotrophic protein that has been implicated as a biomarker for anxiety and depressive disorders, which comprise a significant component of the global burden of disease. Research using rodents has indicated that FGF2 is part of the stress response, but whether this translates to humans has yet to be investigated. In this study, we aimed to explore the potential role of FGF2 in the human stress response by examining its association with physiological and psychological processes during and following the Trier Social Stress Test (TSST). Methods Participants in the active stress experiment (N  =  87) underwent the TSST, provided saliva samples to obtain levels of cortisol and FGF2, and reported on post-event rumination related to the TSST task over the following week. Participants in the no-stress experiment (N  =  25) provided saliva samples for measurement of FGF2 and cortisol across a corresponding time period. Results Salivary FGF2 levels changed after the TSST and were associated with the pattern of change in salivary cortisol. Cortisol responses in the active stress condition were blunted in females (relative to males), however, sex did not interact with any other effect. FGF2 reactivity (ie, the magnitude of change over time) was not correlated with cortisol reactivity. Lower FGF2 reactivity following the TSST, but not overall FGF2 levels, or cortisol, was associated with higher fear of negative evaluation, repetitive negative thinking and post-event processing, as well as repetitive negative thinking in the week following the TSST. Participants in the no-stress experiment showed a decrease in cortisol, yet no change in their FGF2 levels. Conclusion These findings suggest that FGF2 is involved in the human stress response and higher levels of FGF2 reactivity may be associated with protective cognitive processes following stress exposure.
Membrane curvature and PS localize coagulation proteins to filopodia and retraction fibers of endothelial cells
Authors: Carman Christopher V. , Nikova Dessislava N. , Sakurai Yumiko , Shi Jialan , Novakovic Valerie A. , Rasmussen Jan T. , Lam Wilbur A. , Gilbert Gary E. 
Published: July 2022

Abstract
Prior reports indicate that the convex membrane curvature of phosphatidylserine (PS)-containing vesicles enhances formation of binding sites for factor Va and lactadherin. Yet, the relationship of convex curvature to localization of these proteins on cells remains unknown. We developed a membrane topology model, using phospholipid bilayers supported by nano-etched silica substrates, to further explore the relationship between curvature and localization of coagulation proteins. Ridge convexity corresponded to maximal curvature of physiologic membranes (radii of 10 or 30 nm) and the troughs had a variable concave curvature. The benchmark PS probe lactadherin exhibited strong differential binding to the ridges, on membranes with 4% to 15% PS. Factor Va, with a PS-binding motif homologous to lactadherin, also bound selectively to the ridges. Bound factor Va supported coincident binding of factor Xa, localizing prothrombinase complexes to the ridges. Endothelial cells responded to prothrombotic stressors and stimuli (staurosporine, tumor necrosis factor-α [TNF- α]) by retracting cell margins and forming filaments and filopodia. These had a high positive curvature similar to supported membrane ridges and selectively bound lactadherin. Likewise, the retraction filaments and filopodia bound factor Va and supported assembly of prothrombinase, whereas the cell body did not. The perfusion of plasma over TNF-α–stimulated endothelia in culture dishes and engineered 3-dimensional microvessels led to fibrin deposition at cell margins, inhibited by lactadherin, without clotting of bulk plasma. Our results indicate that stressed or stimulated endothelial cells support prothrombinase activity localized to convex topological features at cell margins. These findings may relate to perivascular fibrin deposition in sepsis and inflammation.
Disparities in trial enrollment and outcomes of Hispanic adolescent and young adult acute lymphoblastic leukemia
Authors: Muffly Lori , Yin Jun , Jacobson Sawyer , Wall Anna , Quiroz Elisa , Advani Anjali S. , Luger Selina M. , Tallman Martin S. , Litzow Mark R. , Foster Matthew C. , Erba Harry P. , Appelbaum Frederick R. , Larson Richard A. , Keegan Theresa H.M. , Stock Wendy 
Published: July 2022

Abstract
In this secondary analysis of Hispanic adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) treated on Cancer and Leukemia Group B (CALGB) 10403, we evaluated outcomes and geographic enrollment patterns relative to US population data. We used demographic, clinical, and survival data on AYAs enrolled on CALGB 10403 (N = 295, 2007-2012). Surveillance, Epidemiology, and End Results registries provided overall survival (OS) for US AYA ALL by ethnicity/race. North American Association of Cancer Registries provided AYA ALL incidence overall and proportion among Hispanics by US state. Of AYAs enrolled on CALGB 10403, 263 (89%) reported ethnicity/race: 45 (17%) Hispanic, 172 (65%) non-Hispanic White (NHW), 25 (10%) non-Hispanic Black (NHB), and 21 (8%) other. Compared with NHWs, Hispanic and NHB patients had lower household income, and Hispanic patients were more likely to harbor high-risk CRLF2 aberrations. Relative to US estimates, where Hispanic patients represented 46% of newly diagnosed AYA ALL patients and experienced inferior OS compared with NHW (P &lt; .001), Hispanic AYAs on CALGB 10403 did as well as NHW patients (3 year OS, 75% vs 74%; P = NS). Hispanic patients also had higher rates of protocol completion (P = .05). Enrollments on CALGB 10403 differed relative to the distribution of Hispanic AYA ALL in the United States: enrollment was highest in the Midwest; t and only 15% of enrollees were from states with a high proportion of Hispanic AYA ALL patients. In summary, Hispanic patients treated on CALGB 10403 did as well as NHWs and better than population estimates. Geographical misalignment between trial sites and disease epidemiology may partially explain the lower-than-expected enrollment of Hispanic AYA ALL patients.
Reassessing the intrusive tempo and magma genesis of the late Variscan Aar batholith: U–Pb geochronology, trace element and initial Hf isotope composition of zircon
Authors: Ruiz Mélissa , Schaltegger Urs , Gaynor Sean P. , Chiaradia Massimo , Abrecht Jürgen , Gisler Christian , Giovanoli Federico , Wiederkehr Michael 
Published: July 2022

AbstractThe Variscan orogeny was responsible for the formation of a significant volume of igneous basement throughout present-day Europe. Detailed understanding of these rocks has, however, been obfuscated by significant overprinting during younger geologic events. In order to better understand the formation of this basement, we present U–Pb dates, trace element concentrations and Hf isotope compositions of zircon from 17 intrusions of the Variscan Aar batholith, located in the Aar Massif, Central Alps, Switzerland. Laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) was used to generate a large set of U–Pb dates, trace element and Hf isotope compositions on untreated zircon, as well as zircon pretreated by chemical abrasion. Furthermore, a subset of samples was also analyzed for high-precision U–Pb geochronology using chemical abrasion, isotope dilution, thermal ionization mass spectrometry (CA-ID-TIMS). The U–Pb dates of both dating techniques are significantly dispersed, indicating that they are influenced by multiple forms of complexity, including inheritance, domains of secondary alteration likely related to Alpine overprint or growth, decay damage related Pb-loss, and potentially protracted magmatic growth. Decay-damage related Pb-loss is likely a subordinate source of age scatter within the data, therefore chemical abrasion pretreatment is not capable of completely mitigating the observed analytical scatter. After rejection of outliers, the remaining data still exhibit excess scatter of several percent among 206Pb/238U dates in individual samples, however it is possible to interpret reasonable geologic ages from these data. These new U–Pb zircon age interpretations indicate the Aar batholith grew incrementally through four major magmatic pulses, which occurred at approximately 348, 333, 309 and 298 Ma. Based on the trace element and Hf isotope geochemistry, the melt source(s) of the Aar batholith evolved throughout the duration of batholith formation and growth. The transitioning from (i) melting of depleted mantle at 348 Ma during a stage of active continental arc magmatism (εHf =  + 12 to + 10), (ii) melting of metasomatically enriched lithospheric mantle, possibly contaminated by crust during the 333 Ma pulse (εHf  = − 10 to − 3), followed by (iii) an increasing incorporation of a juvenile mantle components during the 309 and 298 Ma pulses (εHf  = − 3 to + 6). Finally, these new U–Pb ages yield a more detailed understanding of the Variscan Aar batholith by integrating the new detailed mapping of Aar Massif for the Geological Atlas of Switzerland, allowing for more accurate characterization and categorization of variably deformed heterogeneous intrusive bodies.
Interleukin-7 regulates CD127 expression and promotes CD8+ T cell activity in patients with primary cutaneous melanoma
Authors: He Hongxia , Qiao Binjun , Guo Shuping , Cui Hongzhou , Zhang Ziyan , Qin Junxia 
Published: July 2022

AbstractBackgroundInterleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8+T cell exhaustion. The mechanisms underlying CD8+T cell responses to IL-7 in melanoma remain not completely elucidated. We previously showed reduced IL-7 level in melanoma patients. Thus, the aim of this study was to investigate the effect of IL-7 regulation on CD127 expression and CD8+T cell responses in melanoma.MethodsHealthy controls and primary cutaneous melanoma patients were enrolled. Membrane-bound CD127 (mCD127) expression on CD8+T cells was determined by flow cytometry. Soluble CD127 (sCD127) protein level was measured by ELISA. Total CD127 and sCD127 mRNA level was measured by real-time PCR. CD8+T cells were stimulated with recombinant human IL-7, along with signaling pathway inhibitors. CD8+T cells were co-cultured with melanoma cell line, and the cytotoxicity of CD8+T cells was assessed by measurement of lactate dehydrogenase expression.ResultsPlasma sCD127 was lower in melanoma patients compared with controls. The percentage of CD8+T cells expressing mCD127 was higher, while sCD127 mRNA level was lower in peripheral and tumor-infiltrating CD8+T cells from melanoma patients. There was no significant difference of total CD127 mRNA expression in CD8+T cells between groups. IL-7 stimulation enhanced total CD127 and sCD127 mRNA expression and sCD127 release by CD8+T cells. However, mCD127 mRNA expression on CD8+T cells was not affected. This process was mainly mediated by phosphatidylinositol 3-kinase (PI3K) pathway. CD8+T cells from melanoma patients exhibited decreased cytotoxicity. IL-7 stimulation promoted CD8+T cell cytotoxicity, while inhibition of PI3K dampened IL-7-induced elevation of CD8+T cell cytotoxicity.ConclusionThe current data suggested that insufficient IL-7 secretion might contribute to CD8+T cell exhaustion and CD127 dysregulation in patients with primary cutaneous melanoma.