bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Absorbed Dose Estimation of 111In-DOTA-PR81 as a Novel High Potential Agent for Breast Cancer Imaging
Authors: Yousefnia Hassan , Zolghadri Samaneh , Alirezapour Behrouz 
Published: August 2022

Purpose:
In this study, the human absorbed dose of 111In-DOTA-PR81 as a new radioimmunoconjugate for single-photon emission computed tomography (SPECT) imaging of MUC1 + breast cancer was determined.

Materials and Methods:
The complex was prepared at optimized conditions in about 1 h and 38°C. The radiochemical purity of the tracer was investigated using the instant thin-layer chromatography method method, showing purity of higher than 96%. After evaluating the stability of the product in human serum and room temperature, the biological distribution of the radiolabeled compound was studied in normal rats and tumor-bearing mice. Finally, the human absorbed dose of the complex was estimated based on animals’ data using radiation dose assessment resource and Spark et al. methods.

Results:
High uptake of the complex in MUC1 + breast tumors compared to other nontarget organs shows that the radioimmunoconjugate is a beneficial agent for SPECT imaging of MUC1 + breast cancer. Human organs absorbed dose estimation of the complex demonstrated the highest amounts of the absorbed dose are in the liver and kidneys with 0.384 and 0.245 mGy/MBq, respectively.

Conclusions:

111In-DOTA-PR81 radioimmunoconjugate is a high potential agent for MUC1 + breast cancer SPECT imaging and estimated absorbed dose values could helpfully use for the determination of the maximum injectable dose.
Control of Healthcare-Associated Infections using Silver Nanoparticles in Radiology
Authors: Ahn Gyunheung , Kim Sungchul 
Published: August 2022

Aims:
The control of healthcare-associated infections (HCAIs) is a significant concern in the field of radiology due to multiple contact-transmitted pathogens on imaging devices. The antimicrobial effects of silver nanoparticles (AgNPs) in preventing HCAIs and their effects on imaging quality were evaluated.

Methods:
The antimicrobial effects of AgNPs were tested on prevalent contact-transmitted pathogens present in radiology examination rooms, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE), Pseudomonas aeruginosa, and Acinetobacter baumannii. Furthermore, we investigated the effects of AgNPs on X-ray image quality using humanoid head and hand phantom.

Results:
AgNPs did not affect the quality of X-ray images. They had antimicrobial effects against Gram-positive Bacillus, including MRSA, VRE, and Gram-negative Bacillus, including P. aeruginosa and A. baumannii.

Conclusion:
AgNPs are considered effective in controlling HCAIs in radiology through sterilization by coating shooting devices and accessories where physical contact between patients and healthcare professionals is frequent.
Does Single Computed Tomography Attenuation Correction able to Surrogate Serial Computed Tomography Attenuation Correction in Single-Photon Emission Computed Therapy Imaging for Peptide Receptor Radionuclide Therapy Dosimetry Result?
Authors: Said Mohamad Aminudin Bin , Razak Hairil Rashmizal Abdul , Musarudin Marianie Bnti 
Published: August 2022

Peptide Receptor Radionuclide Therapy (PRRT) is the administration of a radionuclide, such as the Lu-177 label, along with a pharmaceutical agent to destroy the lesion cell. The first cycle of Lu-177 DOTA-TATE is an excellent way to estimate radionuclide uptake for organs at risk. To estimate the absorbed dose for a kidney, serial SPECT-CT imaging with up to five sets is required. In general, serial CT on patients would result in additional external exposure and extra time consuming, especially for low dose CT such as cone beam CT technology. However, by introducing a new method, such as optimized single CT (24 h) to perform with serial SPECT attenuation correction, additional external exposure from serial CT exposure could be reduced.

Aims:
The purpose of this study is to assess the agreement between single CT scanning as CT attenuation Correction with serial CT scanning for serial SPECT imaging as well as estimated absorbed dose to the organ at risk.

Settings and Design:
During the first cycle of Lu177-DOTA-TATE, all patients should undergo internal dosimetry technique using SPECT-CT imaging with a PHILIP Brightview XCT gamma camera. The quantifications of SPECT images are being used to measure the uptake activity to the organ. In this investigation, Partik's categorical grading criteria are being used to convert the numeric value of Lin's concordance coefficient into an ordinal scale.

Method:
Total of 9 patients at our institution was administered with Lu177-DOTA-TATE enroll in this study. SPECT-CT data were acquired using automatic body contouring with a total of 48 angular views at steps of 6° (15 s/projections). The pixel size is 4.66 x 4.66 x 4.66 mm, the images size set to one, and SPECT data has been acquired for three-bed positions extending from the abdomen to the thorax region. Low-dose CT imaging performed at an X-ray tube voltage of 120 kVp.

Results:
Our current result demonstrated by single CT scanning for SPECT attenuation shown the excellent agreement with standard serial CT imaging for organs at risk such as kidney 0.999, spleen 0.9951, liver 0.9951 and bladder 0.9972.

Conclusions:
When compared to the previous method, patients benefit significantly more from this study, such as lower CT exposure.
Assessment of Knowledge-Based Planning Model in Combination with Multi-Criteria Optimization in Head-and-Neck Cancers
Authors: Anchineyan Pichandi , Amalraj Jerrin , Krishnan Bijina Themantavida , Ananthalakshmi Muthuselvi Chockalingampillai , Jayaraman Punitha , Krishnasamy Ramkumar 
Published: August 2022

Aim:
The aim of this study was to build knowledge-based planning model (KBPM) for head-and-neck (HN) cancers using volumetric-modulated arc therapy (VMAT), optimized with multi-criteria optimization (MCO), and to evaluate KBPM plan quality with clinical plan (CP) using in-house developed Python script.

Materials and Methods:
Two hundred previously treated simultaneously integrated boost (SIB) HN VMAT plans (RapidArc®) were selected for creating KBPM. These plans were further optimized using MCO to strike right trade-off between target and organs at risk (OARs). The script was written using Python V3.7.1 to automatically extract and analyze treatment plan dosimetric parameters through Eclipse Scripting Application Programming Interface (ESAPI). Analyzed plans that met deliverable quality were modeled using regression-based KBPM framework. The trained model is validated with 35 cohorts of HN SIB patients.

Results:
MCO plans were able to improve the OAR sparing without compromising target coverage compared to user-optimized CPs except for increased heterogeneity. With MCO, spinal cord dose D0.03cc is reduced by 3.2 Gy ± 1.8 Gy, parotid mean dose by 2 Gy ± 1.7 Gy compared to CPs, respectively. MCO-based KBPM plans were comparable to CP with improved sparing for left and right parotids by 11.5% and 7.8%, respectively.

Conclusion:
MCO-based KBPM plans were superior to user plans in terms of OAR sparing and user need to spend more time to meet the model-based plan outcomes. Created KBPM planning is simple and efficient to generate estimate for OAR sparing to guide entry and intermittent planners to improve their clinical planning skills with lesser planning time. Python ESAPI is a powerful tool to extract plan parameters and quickly evaluate either individual or a cohort of plans.
Quantitative Comparison of Dosimetric Data Between the Indigenous Baseplate and Commercially Available Carbon Fiber Baseplate for 6 and 15 MV Photon Energy
Authors: Gayake Umesh Bharat , Tike Pramod , Bangare Mamata , Raveendran Vysakh , Phurailatpam Reena , George Karishma , Musne Vishnu , Dhore Arun 
Published: August 2022

Background:
This study aims to design an indigenous baseplate (ID baseplate) that is economically viable and dosimetrically comparable for radiotherapy patient treatment. An ID baseplate was designed and manufactured using wood plastic composition materials that are readily available in the market and were compared dosimetrically with the commercially available carbon fiber baseplate (CF baseplate).

Materials and Methods:
Surface dose and beam attenuation properties of both the baseplates (ID and CF) were measured using a parallel plate chamber and compared with the dose calculated from the treatment planning system (TPS). Separate computer tomography images of both the baseplates were acquired by placing solid water phantoms. These images were used for surface dose calculation in the TPS and were validated with experimental measurements. Proper densities were assigned to the couch and baseplates to avoid uncertainties in dose calculations. All measurements were performed at field sizes 10 cm × 10 cm for 6 MV and 15 MV photon beams.

Results:
The percentage surface dose measured for the ID baseplate and CF baseplate was found to be matching for 6 MV beam (98.2% and 97%, respectively); however, for the 15 MV beam, the ID baseplate showed a higher surface dose of 98.6% compared to CF baseplate (87.4%). For the ID baseplate, the percentage difference in the surface dose between that TPS calculated value and the measured values were 1.6% and 1.4% for 6MV and 15MV, respectively. The ID baseplate showed higher beam attenuation than the CF baseplate by 2.2% for the 6MV beam and 3.4% for the 15MV beam when proper electron densities were not assigned. The difference between the TPS calculated dose and delivered dose was achieved within 3% after assigning proper electron density to the couch and baseplate.

Conclusions:
The ID baseplate has shown acceptable dosimetric results and can be an economically viable alternative to the commercially available CF baseplates. The manufacturing cost of the ID baseplate was ten times cheaper than the CF baseplate.
Immune Tolerance Induction Experience from a Single Institute in the United Arab Emirates
Authors: Ahmed Awan Najam Ahmed Muhammad , Mohamed Alreyami Layla Ali Eisa , Al Mulla Asia Ahmad Abdallah , Alremeithi Majed Mohammed , Khanani Muhammad Faisal 
Published: August 2022

Background:
Immune tolerance induction (ITI) is the gold standard approach for eradicating inhibitors and increasing patient tolerance to factor VIII. The success rate of ITI may vary depending on patient variables and factors relating to the pattern of treatment for the induction of immune tolerance. Children with recently diagnosed inhibitors are the best candidates for ITI, and those with favourable expected results should be offered ITI as soon as inhibitors are identified. Recombinant factor VIII Fc fusion protein has proved a therapeutic advantage in patients with high factor VIII inhibitor titers

AIMS AND OBJECTIVES:
To evaluate the clinical characteristics and outcomes of ten hemophilic pediatric patients who underwent ITI therapies to eliminate FVIII inhibitors at Tawam Hospital, UAE

MATERIALS AND METHODS:
The data of ten hemophilia A children aged 2–7 years with high inhibitor titers who underwent ITI therapy at Tawam Hospital, UAE, were retrospectively collected for this case series. A comparison of bleeds before and after the ITI therapy was also made. Patients with either failed or partially successful primary ITI therapy underwent rescue ITI therapy. Data analysis was performed using SPSS version 26.

RESULTS:
Full success was achieved in 60% (6/10) of the patients, 10% (1/10) achieved partial success, whereas 30% (3/10) failed the primary ITI therapy. The rescue ITI therapy was successful in 50% (2/4) of the patients and the remaining 50% (2/4) achieved partial success [Table 2]. The rescue ITI was successful in 66% (2/3) of those patients who received Elocta and partially successful in 33% (1/3)

CONCLUSION:
ITI therapy is the gold standard for the eradication of antibodies against FVIII. The patients with good expected outcomes should be offered ITI as soon as the inhibitors are confirmed. The use of extended half life rFVIIIFc demonstrated therapeutic benefit, particularly in challenging ITI patients with high inhibitor titers
Infâncias, arte, cultura e as práticas de terapia ocupacional: partes de uma busca/ Childhood, art, culture and occupational therapy practices: parts of an investigation
Authors: Araújo Silva Juliana , Dias de Castro Eliane 
Published: August 2022

Objetivo: Pretende-se relatar o desenvolvimento da pesquisa “Cartografia das práticas artísticas com crianças e jovens em espaços de arte: propostas e experimentações no contexto nacional”. Síntese dos elementos do estudo: realizou-se uma revisão bibliográfica que visibiliza a escassa publicação dos terapeutas ocupacionais sobre o acesso de crianças a espaços e ações de arte e cultura, embora existam publicações sobre a população jovem em diferentes contextos. Conclusão: Os materiais estudados fortalecem a percepção que o acesso à cultura e às artes enfrentam restrições e são necessários esforços para transformar esta situação, potencializando processos de subjetivação, emancipação cultural, produção da saúde e da vida desta população.Palavras-chave: Terapia Ocupacional Tendências. Infância e juventude. Arte. Cultura. Conhecimento. Abstract Objective: It is intended to report the development of research “Cartography of artistic practices with children and young people in art spaces: proposals and experiences in the national context”. Synthesis of the elements of the study: a bibliographic review was carried out that highlights the scarce publication of occupational therapists about children access to art and culture spaces and actions, although there are publications about the young people in different contexts. Conclusion: The study strengthen the perception that culture and arts access face restrictions and efforts are needed to transform this situation, enhancing subjectivation process, cultural emancipation, production of health and life for this population.Keywords: Occupational Therapy/trends. Childhood and youth. Art. Culture. Knowledge ResumenObjetivo: Presentar el desarrollo de la investigación “Cartografía de prácticas artísticas con niños y jóvenes en espacios de arte: propuestas y experimentaciones en el contexto nacional”. Síntesis de los elementos de investigación: se realizó una revisión bibliográfica que muestra la escasa publicación de terapeutas ocupacionales sobre el acceso de los niños a los espacios y acciones artísticas e culturales, aunque existen publicaciones sobre la población joven en diferentes contextos. Conclusion: Los materiales estudiados fortalecen la percepción que el acceso a la cultura y las artes enfrenta restricciones y se requieren esfuerzos para transformar esta situación, potenciando procesos de subjetivación, emancipación cultural, producción de salud y vida para esta población.Palabras clave: Terapia Ocupacional/tendencias. Infancia y juventude. Arte. Cultura. Conocimiento.
ANALISIS PENGAKUAN PENDAPATAN PREMI ASURANSI UNDERWRITING BERDASARKAN PSAK NO. 28 TAHUN 2012 PADA PT. ASKRINDO CABANG MAKASSAR
Authors: Yasmi  , Andi Arimbi Mappidemmang  
Published: August 2022

Penelitian ini menganalisis mengenai pengakuan pendapatan premi asuransi underwriting yang dilakukan pada PT. Askrindo Cabang Makassar. Tujuan penelitian ini yaitu untuk menganalisis metode pengakuan pendapatan yang diterapkan pada PT. Askrindo Cabang Makassar, Keterkaitan pengakuan pendapatan terhadap premi asuransi underwriting, serta kesesuaian pengakuan pendapatan yang diterapkan oleh PT. Askrindo Cabang Makassar dengan Pernyataan Standar Akuntansi Keuangan (PSAK) No. 28 Tahun 2012.
Berdasarkan hasil analisis yang dilakukan oleh penulis dapat ditarik kesimpulan bahwa pengakuan pendapatan premi asuransi underwriting yang telah diterapkan oleh PT. Askrindo Cabang Makassar telah sesuai dengan PSAK No. 28 Tahun 2012 hanya saja pencatatan premi yang belum merupakan pendapatan yang diterapkan oleh PT. Askrindo Cabang Makassar masih belum sesuai dengan PSAK No. 28 TAhun 2012.
ANALISIS SISA HASIL USAHA KOPERASI SIMPAN PINJAM BERKAT CABANG ANTANG MAKASSAR BEFORE AND MASA NEW NORMAL PANDEMI COVID-19
Authors: Nurbayani  , Teri  , Salmawati  
Published: August 2022

Penelitian ini bertujuan untuk Analisis Sisa Hasil Usaha Koperasi Simpan Pinjam Berkat Cabang Antang Makassar Befor and Masa New Normal Pandemi Covid-19. Penelitian ini bersifat kuantitatif dan jenis penelitian ini jika ditinjau dari tujuan dan sifatnya adalah studi deskriptif.
Hasil dari penelitian ini menunjukan bahwa; Berdasarkan metode analisis vertikal, neraca Koperasi Simpan Pinjam Berkat Cabang Antang Makassar Periode 30 Juni 2019 - 30 Juni 2020 menunjukkan hasil yang kurang baik. Aset-aset koperasi setiap tahunnya berfluktuasi, begitupun pada modal sendiri. Pada utang jangka panjangnya mengalami penurunan, yang berarti bahwa koperasi sudah mampu membayarkan utangnya dan sudah tidak lagi bergantung pada utang jangka panjang dalam menutupi kerugiannya. Kemudian, pada laporan sisa hasil usaha juga menunjukkan trend yang tidak baik. Dimana, setiap tahunnya sisa hasil usaha yang diperoleh koperasi mengalami penurunan.
Projetar a vida na Pandemia
Authors: Talytha Cardozo Angelo  , Rafael Magalhães Costa  
Published: August 2022

O presente artigo busca compreender de qual maneira o Programa Escola Viva gasta o tempo dos discentes na formação para o Mundo do Trabalho, principalmente os indivíduos cursando o Ensino Médio, considerando a faixa etária da Geração Z, com suas características particulares no que diz respeito a tecnologia e perspectivas de carreira, continuamente, a postura do Governo Estadual do Espírito Santo diante da Pandemia do COVID-19 na Educação, em razão do distanciamento social que ocasionou na suspensão das aulas presenciais no período inicial. Ademais, com aporte teórico no texto constitucional, em documentos normativos nacionais e estaduais expressos em portarias, decretos e resoluções, além da análise da disciplina “Projeto de Vida”, assim como os autores: Foucault (2019), Thompson (1998) e Byung-Chul Han (2017), entre outros. Metodologicamente, optou-se pela pesquisa explicativa, através da abordagem qualitativa e natureza básica, contando com o procedimento de pesquisa bibliográfica no que comunga o levantamento dessas fontes. Por fim, como resultados, é possível contemplar a juventude como um grupo ausente de experiência, de modo que a passagem da escola para o Mundo do Trabalho, na Escola Viva, é amparada nos pilares construídos junto ao Projeto de Vida pela díade da identidade pessoal e percepção do mundo ao redor, esse elemento permite mais do que ocupar o tempo do estudante no Turno Único da instituição de ensino, mas gastá-lo com garantia de retorno da autonomia incentivada de forma imperiosa no currículo.

Palavras-chave: Mundo do trabalho; Pandemia; Geração Z; Escola Viva; Projeto de Vida.

ABSTRACT
The article understands the search for how the Escola Viva o Tempo dos Estudantes Program in the present training for the World of Work, especially the private high school students, considering the Generation Z range, with its characteristics with regard to age Technology and career prospects, continuous, the stance of the State Government of Espírito Santo of the COVID-19 Pandemic in Education, due to the social distance that caused the suspension of face-to-face classes in the period. As well as the authors: Fouca Thompson (2019) and Byung: Fouca Thompson (2019) and Byung: Fouca Thompson (2019) and Byung: Fouca Thompson (2019) -Chul Han (2017), among others. Methodologically, an explanatory research was chosen, as well as through qualitative and basic research, counting on the bibliographic research procedure in which the survey of these sources shares. Finally, as a result, it is possible to contemplate youth as a group lacking experience, so that the transition from school to the World of Work, at Escola Viva, is supported by the pillars built with the Life Project by the dyad of personal identity. and the perception of the world around teaching, this element allows the student institution to occupy more time in the curriculum, but to spend it with a guarantee of the return of autonomy that is imperatively encouraged in the curriculum.
Entrepreneurship Post-C19: Gender and Fnancing Abroad
Authors: Shah Pratiti , Gonzalez Laura 
Published: August 2022

Purpose. This study follows the trajectory in the United States and India of 35 entrepreneurs with similar backgrounds in India. It controls for irrelevant-to-this-study factors that impact financing and entrepreneurial paths, and sheds light into the at-times contradictory gender findings in the literature.
Design/methodology/approach. The study is based on interviews with upper-middle class entrepreneurs from business-oriented Mumbai-Maharashtra, India. Out of the 35 highly educated entrepreneurs, one third are women, 21 have educational experience in the U.S. and 16 live in the U.S. This controlled setting is particularly fitting to examine gender effects and offer suggestions for the digitally led C-19 recovery. Indian immigrants have founded about a third of U.S. startups, besides more engineering and technology firms than immigrants born in the next nine immigrant-founder countries combined.
Findings. Both in India and U.S., and despite similar backgrounds, education, no dependents, and similar or more advantageous immigration status in U.S., women entrepreneurs start their businesses later, lack collateral and equity partners, and borrow less.
Practical implications. The findings highlight the potential for debt and equity crowdfunding as well as other fintech services to enhance opportunities for women entrepreneurs.
Originality. This is the first study of gender and financing entrepreneurship in an intercontinental controlled environment. The setting enables an enhanced focus on gender and financing, a priority for academics, practitioners, and policy makers.
Types of transport documents to be studied in cases of accidents involving fixed-route vehicles
Authors: Дронова О.Б. , Тарасова В.И. 
Published: August 2022

В статье рассмотрено доказательственное значение транспортных документов, необходимых в процессе эксплуатации маршрутных транспортных средств (автобусов и маршрутных такси). Выделены их особенности применительно к процессу расследования дорожно-транспортных преступлений с участием данного вида транспорта. Авторами статьи перечислены основные положения законодательства, которыми должны руководствоваться юридические лица и индивидуальные предприниматели, осуществляющие деятельность, связанную с оказанием услуг по перевозке пассажиров. Представлена авторская классификация транспортных документов, раскрываются особенности доказательственного значения содержащихся в них сведений.
The scientific article considers the evidentiary value of transport documents required during the operation of fixed-route vehicles (buses and fixed-route taxis, which are the most emergency-dangerous type of public transport). Their features are highlighted in relation to the process of investigating traffic crimes involving this type of transport. The authors list the main provisions of the legislation that should guide legal entities and individual entrepreneurs engaged in activities related to the provision of passenger transportation services. The author's classification of transport documents is presented, the features of the evidentiary value of the information contained in them are revealed.