bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of Dietary Undenatured Type II Collagen: A Pilot Open-Label Overdose Clinical Investigation
Authors: Shiojima Yoshiaki , Takahashi Megumi , Takahashi Ryohei , Moriyama Hiroyoshi , Maruyama Kazuo , Bagchi Debasis , Bagchi Manashi 
Published: March 2022

Background: In advancing age population worldwide, joint discomfort and poor locomotive functions are symptoms, which are often detected. Aggravation of such symptoms potentially develops into osteoarthritis (OA) as characterized by the loss of articular cartilage in the joints of the hand, spine, knee, foot, and hip. For joint health complications, selected functional foods are frequently supplemented orally to alleviate such symptoms. In Japan, Foods with Function Claims (FFC) regulatory system is now positioned within the framework of “so-called health foods” allowing to make functional claims such as brain health and weight control claims. Moreover, a wide variety of knee joint care FFC products are presently available in the marketplace and have attracted much attention of the elderly people, expecting improvements in joint locomotive functions such as walking, sitting, standing, and climbing the stairs for the quality of life (QOL). Supplementation of undenatured type II collagen powder (NEXT-II®) in hard capsules has been clinically proven to improve such joint functions fulfilling part of the FFC rigorous guidelines, while ensuring adequate safety as foods is a crucial prerequisite for filing FFC product dossier.Methods: Twenty-two healthy male and female volunteers (age = 20-74 years) participated in this pilot open-label overdose clinical trial over a period of 4 consecutive weeks. All subjects were also monitored and assessed additional 2 weeks after the completion of the NEXT-II® supplementation period as washout or supplement-free period. Subjects took a 10-fold (10-X) dose of NEXT-II® (400 mg NEXT-II/day containing 32 mg of undenatured type II collagen/day). Daily recommended dose of NEXT-II® is 40 mg/day (containing 3.2 mg of undenatured type II collagen/day) after breakfast. Physical health examination, hematological analysis, blood ,biochemistry examination, and urinalysis were performed. All subjects completed the supplementation of NEXT-II® for 4 weeks and had additional 2 weeks of washout or supplement-free period. All subjects recorded daily diaries. Results: Results demonstrated no significant differences at 0 week (baseline), 2 weeks, and 4 weeks of NEXT-II®supplementation. Furthermore, no significant differences were observed even after 2 weeks of the washout period. No adverse events were observed.Conclusions: Supplementation of 10-fold dose of NEXT-II® to the volunteers was well-tolerated and exhibited the broad-spectrum safety without observing any adverse effects in healthy Japanese subjects.Keywords: Undenatured type II collagen, NEXT-II®, Safety, Overdose supplementation, Clinical study, Foods with Function Claims (FFC)
Interfaz Tiflotecnológica para asistir alumnos con discapacidad visual en el uso de un procesador de texto.
Authors: Sánchez Orea Alfonso , Navarro Guerrero María de los Ángeles , Escalante Vega Juana Elisa , Vargas Cerdán María Dolores , Álvarez Rodríguez Francisco Javier 
Published: March 2022

Para considerar una verdadera inclusión de las personas con Discapacidad Visual (PDV) se debe privilegiar su superación laboral e intelectual; además de su independencia de movilidad. El manejo y transformación de la información a través de una computadora para participar en un ambiente educativo es de suma importancia para competir en el mercado profesional, en la búsqueda de incluir a las PDV en el uso de la tecnología se han desarrollado diversas herramientas computacionales educativas o de capacitación que utilizan como interfaz principal el teclado de una computadora. Este trabajo propone generar un paradigma alterno: la utilización del ratón para interactuar con la interfaz de un procesador de texto. Aunque este trabajo se enfoca al desarrollo de competencias para Computación Básica, su utilidad se puede extender a cualquier área educativa que requiera el uso de una computadora.
This paper presents, from a user-centered perspective, the selection of factors for a web tool that seeks to speed up the assessment of the collaborative process. In a first stage, twelve evaluation instruments for teamwork were reviewed, all together gathered 27 factors, which were filtered to determine which of them had the highest frequency in at least 50% or more of such instruments. The result of this stage reduced the assessment factors to 12 and these were submitted to the consideration of 186 students, who worked collaboratively, over a period of four months, intermittently. The results of this second stage reveal that of the 12 factors, five of them were rated as essential and six as very important. Only the factor “External communication” was considered as of regular importance.
Reexamining Syncretism in Late Antique Iconography of a Vault Mosaic
Authors: Dixon Sonia 
Published: March 2022

Late Antiquity, third to seventh centuries, is a period recognized for the continuity and change of Roman culture despite a new religion and political instability. This continuity allowed space for syncretism: an amalgamation of different art, religion, and culture in the Empire. In the following pages, I discuss the understanding of a vault mosaic featuring a charioteer or solar figure within the necropolis in Vatican City, Rome, Italy. For this paper, I use material culture from Rome and Constantinople that dates from the first to fourth centuries in order to contextualize the mosaic with other syncretic works of art and to demonstrate multiple readings of artworks. My focus for this paper is the vault mosaic found in Tomb M, built in the second century (Figure 2). I begin with an examination of the decorative programs of the necropolis including the room with the vault mosaic. Next, I briefly investigate iconographies of the ascension to demonstrate a concern with the afterlife by different audiences. Then, I analyze visual evidence of continuity and change in meaning of imperial iconography on material culture during the reign of Constantine I (r. 306–337) to show more examples of syncretic art by a single patron. My methodological approach decenters Christianity—a point to which I will return—seeking a more accurate contextualization of Late Antique material culture.
At the Center of the Globe: Empiricism and Empire in Jean-Baptiste Carpeaux's Fontaine des Quatres-Parties-du-monde
Authors: Mephokee Hoyon 
Published: March 2022

In 1874, Jean-Baptiste Carpeaux’s (1827-1875) Les Quatre Parties du monde soutenant la sphère céleste (The Four Parts of the World Supporting the Celestial Sphere), also referred to as the Fontaine des quatre-parties-du-monde (Fountain of the Four Parts of the World), was installed at the southern end of the Luxembourg Gardens in Paris (Figure 1). By interrogating the Fontaine’s site and iconography vis-à-vis the Second French Empire, this paper demonstrates that the monument celebrated science as constitutive of French statecraft and empire-building and signaled the institutional relationship of science and politics that justified and support-ed French colonialism. Thus, the Fontaine reveals itself to be a powerful expression and agent of Napoléon III’s regime, as well as an embodiment of its contradictions; beneath the façade of objective and unbiased scientific empiricism, the Second Empire outwardly championed progressive ideals as it built and sustained itself on imperial and racial conservatism.
The 180/20 intermittent athletic test: A new intermittent track test to assess the maximal aerobic speed in middle-distance runners
Authors: Benhammou Saddek , Mourot Laurent , Coquart Jérémy , Belkadi Adel , Mokkedes Moulay Idriss , Bengoua Ali 
Published: March 2022

Objective: The training of middle-distance runners is based on intermittent exercises. However, no study has proposed intermittent test to assess endurance performance for middle-distance athletes. The aims of the present study are 1) to develop a new specific testing for middle-distance runners entitled the 180/20 intermittent athletic test and to examine the validity of this test as compared to a standard continuous test 2) to check whether the maximal aerobic speed obtained from the 180/20 intermittent athletic test is related to the 800-m performance.
Methods: Nineteen male middle-distance runners (age: 21.3 ± 2.2 years, height: 1.75 ± 0.04 m, and body mass: 68.8 ± 3.8 kg) performed in a random order three ﬁeld-tests: a standard test, the 180/20 intermittent athletic test and 800-m time-trial. The new test consisted of repeated 180m distance runs interspersed with 20m of active recovery performed until exhaustion. The speed is increased by 0.5 km.h-1 every 200 m.
Results: The results of this study showed the maximal aerobic speed achieved during the new test was signiﬁcantly correlated to the maximal aerobic speed determined from a standard test (r = 0.82, p < 0.05) with low agreement limits (-1.69–1.48 km.h-1) without systematic bias (-0.10 km.h-1). The maximal aerobic speed in new test was better correlated to the 800-m running performance than the maximal aerobic speed achieved during a standard test (r = -0.78 and r = -0.66, respectively).
Conclusions: The 180/20 intermittent athletic test is a valid test for scheduling intermittent training sessions in middle-distance runners.
INTRODUÇÃO DOS INDICADORES DE KPI À LUZ DO LEAN KATA COACHING PARA A REDUÇÃO DOS ÍNDICES DE TURNOVER E ABSENTEÍSMO ATRAVÉS DA CAPACITAÇÃO DE FUNCIONÁRIOS NO ATENDIMENTO DOS PACIENTES DE UM HOSPITAL
Authors: Moreira Juan 
Published: March 2022

O novo comportamento empresarial impulsionado pela globalização têm provocado crescentes mudanças em diversos setores das organizações. O presente trabalho tem o objetivo de analisar os benefícios adquiridos com a implantação da filosofia Lean Kata Coaching (LKC), reduzindo os índices de turnover e absenteísmo dos colaboradores que atuam diretamente no atendimento de um hospital localizado no interior do estado de São Paulo, que devido às questões de confidencialidade, foi designado neste trabalho como Hospital Beta. Por isso, a fim de tornar a concretização visível aos colaboradores da empresa, nessa análise foi utilizado formulários de maneira descritiva e qualitativa, pois essas formas pesquisa permitem maior interação com o cotidiano da linha de produção organizacional. Através desta pesquisa foi possível evidenciar os benefícios obtidos com a implantação do Lean Kata Coaching (LKC), já que ele se mostra eficiente para empresas prestadoras de serviço, como hospitais. Além disso, pode-se se evidenciar que através das diretrizes fornecidas por esta filosofia possibilitam a aquisição novas competências, elevando a motivação dos colaboradores perante os serviços prestados pelo hospital em evidência.
Palavras-Chave: Gestão por Competências. Indicadores Chave de Desempenho (KPI). Lean Kata Coaching. Atendimento. Hospital.

Abstract: The new business behavior driven by globalization has caused increasing changes in several sectors of the organizations. The present work will analyze the benefits gained from the implementation of the Lean Kata Coaching (LKC) philosophy, reducing turnover rates and absenteeism of employees who work directly in the care of a hospital located in the interior of the state of São Paulo, due to confidentiality issues, was designated as Hospital Beta. Therefore, in order to make the realization visible to employees of the company, in this analysis forms were used in a descriptive and qualitative way, because these research forms allow greater interaction with the daily production organizational line. Through this research it was possible to highlight the benefits obtained with the implementation of Lean Kata Coaching (LKC), since it is efficient for companies that provide service, such as hospitals. In addition, it can be evidenced that through the guidelines provided by this philosophy make it possible to acquire new competencies, raising the motivation of the employees before the services provided by the hospital in evidence.
Keywords: Management by Competences. Key Performance Indicators (KPI). Lean Kata Coaching. Attendance. Hospital.
Clinical, psychological and neuroimaging characteristics of chronic tension headache in elderly persons
Authors: Chichanovskaya L. V. , Slyusar T. A. , Nekrasova T. M. , Slyusar I. N. , Podborsky A. R. , Flax A. G. 
Published: March 2022

The aim of the study. To study clinical, psychological and neuroimaging characteristics of chronic tension headache (CTH) in the elderly.Materials and methods. 92 patients with CHTHN (37 men and 55 women aged 55–74 years) were examined. The control group consisted of 53 people (22 men and 31 women of the same age) who did not have neurological complaints, including headache. Pain intensity was assessed on a 10-point visual analogue scale. The severity of neurological symptoms was determined using the NIH-NINDS scale. For the study of cognitive functions, a short scale for assessing mental status was used Mini Mental State Examination (MMSE) and a frontal assessment battery (FAB). Memory was assessed according to the results of the memory subtest MMSE and the 10 words test. The level of attention was studied using the Schulte table, speech fluency – in the «fluency of speech» subtest of the FAB and in the test of verbal associations, visuospatial functions were assessed using the clock drawing test. Memory was assessed by the results of the subtest of memory MMSE and the 10-words test. The level of attention was studied using the Schulte table, the fluency of speech – in the subtest ‘fluency of speech’ FAB and in the verbal association test, visuospatial functions were assessed using the clock drawing test. Magnetic resonance imaging of the head was performed on a Magnetom Impact Expert (Siemens, Germany) tomograph with a magnetic field strength of 1.5 Tesla in T1 and T2 modes. The localization and severity of leukoaraiosis, signs of external and internal atrophy of the brain were determined, the linear dimensions of the anterior horns and central sections of the bodies of the lateral ventricles were measured, and the indices of the anterior horns and bodies of the lateral ventricles were calculated.Results. Patients with chronic tension headache were characterized by clinical and cognitive heterogeneity: frequent «non-standard» characteristics of headache, severe polymorphism of algic manifestations, high frequency of comorbid disorders, cognitive dysfunction and somatic burden, high representation of leukoaraiosis, external and internal hydrocephalus according to MRI study.
Cerebral stroke in patients with malignant neoplasms (literature review)
Authors: Borsukov A. P. , Lebedev I. A. , Nekrasov D. A. , Zakharchuk E. V. , Boldyreva Yu. V. , Tariverdiyeva Z. N. 
Published: March 2022

The article reflects the significant domestic and foreign literature data result on the development of cerebral stroke against the background of malignant neoplasm analysis and the identification of specific risk factors for brain acute vascular lesions in patients with cancer.Aim. Literature data analysis on cerebral stroke and specific risk factors for its development in patients with malignant neoplasms.Materials and methods. Domestic and foreign literature sources on the influence of oncopathology on the cerebral stroke occurrence subject were studied.Results. The presence of a malignant neoplasm seems to be an independent risk factor for death in patients with cerebral infarction, and its risk is the same in men and women. The main link in acute ischemic brain injury in patients with malignant neoplasms is the tissue factor expression that triggers a coagulation cascade with an increase in the level of D-dimer and other fibrin degradation products. Stroke risk is highest in the first 3 months after the detection of the tumor and significantly decreases by the year.Conclusions. Scientific research of the oncopathology on the cerebral stroke development influence mainly concern the hemostasis study without assessing its platelet component and the oncopathology type in this category of patients, but do not sufficiently reflect the structure of acute cerebrovascular accidents. Literature analysis showed the absence of studies on the relationship between the strokes’ frequency and histological and immunohistochemical data.
Effect of Velocity and Contact Stress Area on the Dynamic Behavior of the Spinal Cord Under Different Testing Conditions
Authors: Jin Chen , Zhu Rui , Xu Meng-lei , Zheng Liang-dong , Zeng Hui-zi , Xie Ning , Cheng Li-ming 
Published: March 2022

Knowledge of the dynamic behavior of the spinal cord under different testing conditions is critical for our understanding of biomechanical mechanisms of spinal cord injury. Although velocity and contact stress area are known to affect external mechanical stress or energy upon sudden traumatic injury, quantitative investigation of the two clinically relevant biomechanical variables is limited. Here, freshly excised rat spinal-cord–pia-arachnoid constructs were tested through indentation using indenters of different sizes (radii: 0.25, 0.50, and 1.00 mm) at various loading rates ranging from 0.04 to 0.20 mm/s. This analysis found that the ex vivo specimen displayed significant nonlinear viscoelasticity at &lt;10% of specimen thickness depth magnitudes. At higher velocity and larger contact stress area, the cord withstood a higher peak load and exhibited more sensitive mechanical relaxation responses (i.e., increasing amplitude and speed of the drop in peak load). Additionally, the cord became stiffer (i.e., increasing elastic modulus) and softer (i.e., decreasing elastic modulus) at a higher velocity and larger contact stress area, respectively. These findings will improve our understanding of the real-time complex biomechanics involved in traumatic spinal cord injury.
Evaluation of Tracheal Stenosis in Rabbits Using Multispectral Optoacoustic Tomography
Authors: Wen Yanting , Wu Dan , Zhang Jing , Jiang Shixie , Xiong Chunyan , Guo Dan , Chi Zihui , Chen Yi , Li Lun , Yang Ying , Liu Ting , Jiang Huabei 
Published: March 2022

Objective: Photoacoustic tomography (PAT) and multispectral optoacoustic tomography (MSOT) are evolving technologies that are capable of delivering real-time, high-resolution images of tissues. The purpose of this study was to evaluate the feasibility of using PAT and MSOT for detecting histology in a rabbit tracheal stenosis model. Method: A total of 12 rabbits (9 stenosis and three control) were randomly divided into four groups (A, B, C and D). Each group consisted of three rabbits, which were staged at the first, fourth, and eighth weeks of stenosis progression, respectively. PAT/MSOT images and corresponding histology from these experimental animals were compared, for analyzing the morphologic features and quantitative tracheal measurements in different tracheal stenosis stage.Result: Both the PAT images and corresponding histology indicated the most severe degree of stenosis in group C. MSOT images indicated notable differences in tracheal contents of group B and D.Conclusion: This study suggests that PAT/MSOT are potentially valuable non-invasive modality which are capable of evaluating tracheal structure and function in vivo.
Associations Between Vaginal Bacteria and Bacterial Vaginosis Signs and Symptoms: A Comparative Study of Kenyan and American Women
Authors: Carter Kayla A. , Balkus Jennifer E. , Anzala Omu , Kimani Joshua , Hoffman Noah G. , Fiedler Tina L. , Mochache Vernon , Fredricks David N. , McClelland Raymond Scott , Srinivasan Sujatha 
Published: March 2022

BackgroundBacterial colonization and associations with bacterial vaginosis (BV) signs and symptoms (Amsel criteria) may vary between populations. We assessed relationships between vaginal bacteria and Amsel criteria among two populations.MethodsKenyan participants from the placebo arm of the Preventing Vaginal Infections (PVI) trial and participants from a Seattle-based cross-sectional BV study were included. Amsel criteria were recorded at study visits, and the vaginal microbiota was characterized using 16S rRNA gene sequencing. Logistic regression models, accounting for repeat visits as appropriate, were fit to evaluate associations between bacterial relative abundance and each Amsel criterion.ResultsAmong 84 PVI participants (496 observations) and 220 Seattle participants, the prevalence of amine odor was 25% and 40%, clue cells 16% and 37%, vaginal discharge 10% and 52%, elevated vaginal pH 69% and 67%, and BV 13% and 44%, respectively. BV-associated bacterium 1 (BVAB1) was positively associated with all Amsel criteria in both populations. Eggerthella type 1, Fannyhessea (Atopobium) vaginae, Gardnerella spp., Sneathia amnii, and Sneathia sanguinegens were positively associated with all Amsel criteria in the Seattle study, and all but discharge in the PVI trial.ConclusionsCore vaginal bacteria are consistently associated with BV signs and symptoms across two distinct populations of women.
Case Report: Dual-Energy Computed Tomography of Cardiac Changes in IgG4-Related Disease
Authors: Wang Ying , Zhou Hui , Hu Ping , Zhao Jie , Mao Yitao , Li Zhixiao , Zhao Xi 
Published: March 2022

BackgroundDual-energy computed tomography (DECT) is used in coronary plaque characterization, myocardial perfusion imaging, and pulmonary embolism diagnosis; however, there is no relevant research on DECT in IgG4-related diseases (IgG4-RD) involving the coronary artery. We are the first to report DECT findings of cardiac morphology and function in IgG4-RD.Patient FindingsMultimodality cardiovascular imaging from a 63-year-old male patient, who presented with IgG4-related pancreatitis, was analyzed. An iodine map and spectral curves were obtained from the DECT, which can help to distinguish between non-calcified plaques and IgG4 lesions of the coronary artery, noninvasive FFRCT (fractional flow reserve derived from coronary computed tomography angiography) and ECV (extracellular volume fraction) demonstrated myocardial ischemia and myocardial fibrosis, respectively.ConclusionThe DECT can detect coronary artery tumor-like lesions caused by IgG4-RD and simultaneously assess the morphological, functional, and histological characteristics of the myocardium. This may help to guide individualized and timely treatment and avoid potentially life-threatening complications.