bluuebunny/crossref_metadata_2025_split huggingface dataset:
UFO procedure as a last resort surgery for massive aortic and mitral annular calcification involving left atrial and ventricular myocardium - a case report
Authors: Wert Leonhard , Pasic Miralem , Heck Roland , Praet Karel M. Van , Kempfert Jörg , Falk Volkmar 
Published: November 2022

Abstract
Background
The UFO procedure was initially developed as a surgical option to enlarge the aortic annulus in patients requiring valve replacement. This technique can be employed to treat extensive endocarditis located in the intervalvular fibrous body (IVFB). One of the indications for a UFO procedure is massive aortic and mitral valve calcification. It is a challenging surgical procedure with a high risk of intraoperative complications.
Case summary
We present a 76-year-old male patient with massive aortic and mitral valve calcification involving the left atrium, the left ventricle and the left ventricular outflow tract. Both valves exhibited severe stenosis and moderate to severe regurgitation. The left ventricle was hypertrophic and the left ventricular ejection fraction was > 55 %. The patient was prediagnosed with persistent atrial fibrillation. The risk of death following heart surgery (EuroSCORE II) was calculated as 9.21 %. We successfully performed a so-called UFO procedure including replacement of both valves without annular decalcification to avoid atrioventricular dehiscence. We enlarged the IVFB and replaced the non-coronary sinus of Valsalva with doubled bovine pericardium. The left ventricular outflow tract was decalcified. The patient was transferred to a local hospital on the 13th postoperative day.
Conclusion
Successful surgical treatment to this extent was demonstrated for the first time. Due to the high perioperative mortality, the surgical treatment of patients with this constellation would be refused in most cases. In our patient, the preoperative imaging showed extreme calcification of both valves and the surrounding myocardium. Excellent preoperative planning and a highly experienced surgical team is necessary.
Machine learning in hypertension detection: a study on World Hypertension Day data
Authors: Montagna Sara , Pengo Martino Francesco , Ferretti Stefano , Borghi Claudio , Ferri Claudio , Grassi Guido , Muiesan Maria Lorenza , Parati Gianfranco 
Published: November 2022

Abstract
Background: Many modifiable and non-modifiable risk factors have been associated with hypertension. However, current screening programs are still failing in identifying individuals at higher risk of hypertension. Given the major impact of high blood pressure on cardiovascular events and mortality, there is an urgent need to find new strategies to improve hypertension detection.
Aim: We aimed to explore whether a machine learning (ML) algorithm can help identifying individuals predictors of hypertension.
Methods: We analysed the data set generated by the questionnaires administered during the World Hypertension Day from 2015 to 2019. A total of 20206 individuals have been included for analysis. We tested five ML algorithms, exploiting different balancing techniques. Moreover, we computed the performance of the medical protocol currently adopted in the screening programs.
Results: Results show that a gain of sensitivity reflects in a loss of specificity, bringing to a scenario where there is not an algorithm and a configuration which properly outperforms against the others. However, Random Forest provides interesting performances (0.818 sensitivity - 0.629 specificity) compared with medical protocols (0.906 sensitivity - 0.230 specificity).
Conclusion: Detection of hypertension at a population level still remains challenging and a machine learning approach could help in making screening programs more precise and cost effective, when based on accurate data collection. More studies are needed to identify new features to be acquired and to further improve the performances of ML models.
The contribution of VNIR and SWIR hyperspectral imaging to rock art studies: example of the Otello schematic rock art site (Saint-Rémy-de-Provence, Bouches-du-Rhône, France)
Authors: Defrasne Claudia , Massé Marion , Giraud Manuel , Schmitt Bernard , Fligiel Damien , Mouélic Stéphane Le , Chalmin Emilie 
Published: November 2022

Abstract
This paper presents a methodological contribution to rock art archaeology by demonstrating the benefits of hyperspectral imaging, a relatively new method, for the understanding of rock art sites. It illustrates the complementarity of VNIR hyperspectral imaging, applied in rare cases to rock archaeology, and SWIR hyperspectral imaging, implemented here for the first time to a rock art panel. Applied to a schematic rock art site in southern France, the Otello rock shelter (Saint-Rémy-de-Provence, France), this method allowed the discovery of numerous new figures invisible to the naked eye or unsuspected after image enhancement with the DStretch plug-in of the Image J software, the individualisation of figures within complex superpositions as well as the discovery of figures covered by weathering products. Moreover, by conferring a spatial dimension to the analysis of pictorial matter, thus allowing a classification of pigments at the scale of the wall, hyperspectral imaging makes it possible to automatically isolate different paintings and to carry out objective groupings of figures on the basis of their composition. Finally, hyperspectral imaging allows us to precisely document, distinguish and characterise weathering products interacting with painted figures. For all of these reasons, this method appears essential to highlight the relative chronology and syntax of iconography, and consequently to understand its cognitive nature.
Experimental determination of concentration factors of Ni, Ru and Sb in the phytoplankton species Phaeodactylum Tricornutum
Authors: Ali Y. , Thomas R. , Holgersson S. , Isaksson M. , Björk Klara Insulander 
Published: November 2022

Abstract
This paper describes the experimental determination of concentration factors (CF) for nickel, ruthenium and antimony in phytoplankton. Better determinations of these CF are, according to sensitivity studies and a literature search, needed to improve the modelling of marine ecosystems at release points and predictions of radiation dose to humans. Nutrient-enriched water samples from Swedish coastal waters are used as a medium for growing of the diatom species P. Tricornutum and radiotracers are used for determination of CF in the laboratory. Conservative estimates of these CF based on the present data are 6 400 L/kg for nickel, 20 000 L/kg for ruthenium and 890 L/kg for antimony, with phytoplankton masses referring to dry weight.
Computer-Aided Multi-Epitope based Vaccine Design against Monkeypox Virus Surface Protein A30L: An Immunoinformatics Approach
Authors: SV Ramprasadh , Rajakumar Santhosh , S Srinivasan , D Susha , Sharma Sameer , Chourasiya Rajan 
Published: November 2022

Abstract

Monkeypox is a viral zoonotic illness resembling smallpox. It was a national epidemic, primarily in Africa, but has lately spread around the world, and as a result, it could evolve into a global pandemic in a relatively short amount of time. So, a multi-epitope vaccine capable of eliciting an immune response against MPXV by exploiting cell envelope protein as a target was therefore designed and created to generate a novel vaccination that is both effective and nearly devoid of adverse effects. The constructed vaccine has T-cell and B-cell epitopes from A30L protein that are highly antigenic, non-allergenic, non-toxic, conserved, and non-homologous. Consequently, they should be able to offer robust protection against the virus. Protein-protein docking was used to foretell the most effective vaccine design by docking with Toll-like receptors (TLR) 2, 3, 4, 6, and 8. In the end, the MD simulation and the immune simulation of the ideal vaccine construct both predicted positive outcomes. Ultimately, In Silico cloning will be employed to construct a vaccine in a large-scale production approach. Additionally, if in vivo and in vitro experiments yield positive results, our results provide an epitope-based peptide fragment that might be a promising entrant for the creation of a vaccine against the monkeypox virus.
Risk of atrial fibrillation in individuals with dysglycemia and diabetes
Authors: Rørth Rasmus , Kriegbaum Margit , Grand Mia Klinten , Jacobsen Peter Karl , Lind Bent Struer , Andersen Christen Lykkegaard , Persson Frederik 
Published: November 2022

Abstract

Background
Diabetes is a risk factor for atrial fibrillation (AF), and increases the risk of thromboembolic events in persons with AF. However, the link between the two conditions is not fully elucidated. Few studies have investigated the association of dysglycemia and incident AF. We investigated the risk of incident AF and prognosis according to diabetes status.
Methods
The Copenhagen Primary Care Laboratory Database was merged with data on medical prescriptions, in- and outpatient contacts and vital status. The risk of AF according to diabetes status was investigated by use of Cox regression models.
Results
Of 354.807 individuals with a hemoglobin A1c (HbA1c) measurement, 28.541(8%) had known diabetes, 13.038(4%) had new onset diabetes and 27.754(8%) had prediabetes (HbA1c 42-47mmol/mol). Persons with dysglycemia (HbA1c > 42mmol/mol) and diabetes were older, more were men, they had lower level of education and were more likely to be living alone. We observed a gradual increase in risk of developing AF from HbA1c levels of 40 to 60 mmol/mol. In adjusted analyses we found a stepwise increase in hazard of AF from normoglycemia over prediabetes to persons with diabetes (No diabetes:1.00 [ref.]; Prediabetes:1.12[1.08–1.16]; New-onset diabetes:1.16[1.10–1.22]); Known diabetes:1.15[1.11–1.20]). Persons with known diabetes had a significant higher hazard of stroke, cardiovascular and all-cause mortality.
Conclusion
Increasing levels of HbA1c were associated with an increased hazard of developing AF. Persons with new onset of diabetes and those with known diabetes had similar hazard of developing AF, however persons with known diabetes had a significant higher hazard of stroke, cardiovascular- and all-cause mortality.
Mapping of the superficial lymphatic network of the breast using indocyanine green injection: an anatomical study
Authors: CLAUDIC Yannis , PERRUISSEAU-CARRIER Anne , DEMARTELEIRE Charlie , HU Weiguo , SEIZEUR Romuald 
Published: November 2022

Abstract
Purpose
Indocyanine green (ICG) is a fluorophore that allows exploration of the arterial and lymphatic network. The superficial lymphatic network of the breast is particularly vulnerable in breast augmentation surgery. The intraoperative use of ICG could help the plastic surgeon during breast augmentation surgery. The aim of this work is to demonstrate the feasibility of mapping the superficial breast lymphatic network using ICG.
Methods
This is an anatomical study. A peri-areolar injection of indocyanine green was performed on cadaveric subjects. At the end, a mapping of their spatial distribution was carried out according to four quadrants, delimited by two perpendicular lines passing by the areola.
Results
We performed 60 breast injections. The lymphatic network could be identified in 53 of them. A total of 80 vessels were found in the superior-external quadrant, 17 in the superior-internal quadrant, 28 in the inferior-external quadrant and 0 in the inferior-internal quadrant.
Conclusion
This work shows that indocyanine green allows the identification of the superficial lymphatic network of the breast. Its use could represent an intraoperative assistance in breast augmentation surgery. This work also confirms the existing anatomical notions with a predominance of the axillary drainage route.
The Role Telegram Application for Information Sharing in the Case of Online Ge’ez Language Learning
Authors: Yenesew Selomon 
Published: November 2022

Abstract
Telegram is one of the application, which used for learning language in the online. The current study was aimed investigate how online learning resources facilitate information sharing for Ge’ez language learning. The study was followed the quantitative research strategy conducted a telegram channels created between 2017 and 2021. The data were collected via a searching of telegram channels in the online, particularly, created in Ge’ez language learning user names. The subscribers and the channels number were presented using frequency and percentage. The correlations between subscribers with other factors were analyzed using SPSS. The introducing of Ge’ez language learning in the telegram application was started in Dec 2017. Thirty-one telegram channels with 85970 subscribers’ channels have been providing Ge’ez language in the online. In the telegram channel Basic to advanced Ge’ez language Learning were available. In 2020, maximum telegram channels were created with its correspondent followers. The trends line of telegram channel between 2017 and 2020 were increasing trends and deceasing in 2021. The number of subscribers and shared link positively and highly correlated each other. Telegram application plays a vital role in Ge’ez language learning via sharing a vast amount of material that facilitate Ge’ez language learning in the online.
The immune landscape in SSc-ILD and tow genes are potential risk factors for pulmonary fibrosis
Authors: Yang Beibei , Rui Hongbing , Xue Juan , Liu Jizan , Xiao Hua 
Published: November 2022

Abstract
Background
Interstitial lung disease (ILD) is the most common cause of death in patients with systemic sclerosis (SSc-ILD) and immune cells are crucial in the onset and development of ILD. The aim of this study was to compare the molecular fingerprint of lung tissue from patients with SSc-ILD with that of lung tissue from normal donors, and to determine the immune landscape according to their gene expression profiles.
Methods
Two gene expression omnibus (GEO) datasets were merged as a test set, and another dataset was selected as the validation set. Lung biopsies and alveolar macrophages from 2 SSc-ILD patients and 2 healthy controls were obtained for further validation. Machine-learning algorithms were used to filter and identify potential diagnostic biomarkers of SSc-ILD in the test set. These biomarkers were examined in a validation dataset and further validated by quantitative real-time PCR and western blotting. CIBERSORT was used to quantify the proportions of immune cells in lung samples from SSc-ILD patients and healthy controls. The link between potential biomarkers and immune infiltration cells was established using a logistic regression approach.
Results
CDH3 upregulated and TNFAIP3 downregulated in SSc-ILD, and their encoded proteins (Cadherin 3 and TNFAIP3, respectively) also showed the same trend of changes. TNFAIP3 protein in alveolar macrophages derived from the alveolar lavage fluid of patients with SSc-ILD was decreased too. The proportion of M2 macrophages in SSc-ILD was significantly higher. TNFAIP3 was negatively correlated with M2 macrophages. CDH3 was positively correlated with plasma cells, M0 macrophages, and resting mast cells, and negatively correlated with M1 macrophages, resting NK cells, activated mast cells, eosinophils, and monocytes.
Conclusions
TNFAIP3 and CDH3 are two potential factors for pulmonary fibrosis. In particular, the lower expression of TNFAIP3 in alveolar macrophages of SSc-ILD patients may be linked to the maintenance of the profibrotic phenotype of macrophages. This research offers a fresh viewpoint on how SSc-ILD manifests itself at the transcriptomic and immune cell level, and may be useful in future therapeutic strategies.
A numerical method for space-time fractional advection-reaction-diffusion problems with generalized Caputo-type derivative
Authors: Heydari M. H. , Razzaghi M. 
Published: November 2022

Abstract
In this study, the generalized Caputo-type fractional derivative is applied to construct a family of fractional advection-reaction-diffusion equations. The orthonormal discrete Chebyshev polynomials are considered to construct a computational method for these equations. The proposed method uses the approximation of the unknown solution by these polynomials and it employs the fractional derivative of these polynomials (which is obtained in this study) along with the collocation method to derive an algebraic system of equations. A smooth solution in terms of the mentioned polynomials is obtained for the introduced fractional problem by solving this system. The implementation and numerical simulations of the method are very simple. Three test problems have been studied to investigate the numerical accuracy of the method.
Impact of energy expenditure on zinc intake in healthy adults
Authors: Guimarães Rafael , Andrade Flavia Cristina Drumond , Donadio Janaina L S , Cozzolino Silvia M F , Rocha Aline dos Santos , Salles Cristina 
Published: November 2022

Abstract

The Institute of Medicine provides references of daily nutrient intake stratified by age and gender groups, considering that the basal metabolic rate varies according to these aspects. In this context, this study aimed to evaluate the recommendation of zinc in healthy adults according to the energy expenditure. The study database "Influence of Gender and SNPs in GPX1 Gene on Biomarkers of Selenium Status in Healthy Brazilians" was used, which collected information from 116 apparently healthy adults recruited in São Paulo. The mean age of the sample was 28.7 ± 7.2 years and the mean for zinc intake was 7.63 ± 3.32 mg, with a statistically significant correlation observed between energy expenditure and zinc intake (R = 0.321; p = 0.004). No linear correlation was found between age and energy expenditure and the difference between sex was not statistically significant.
Conclusion: The metabolic rate can be considered as a reference variable for the recommendation of the daily intake of the nutrient, aiming to avoid deficiencies and food poisoning because of its poor intake.
Food, Cooking and Potteries: A Preliminary Study on the Social Developments of the Neolithic Mijiaya Site in Guanzhong Area, China
Authors: Qu Yating , Zhu Junxiao , Yang Han , Zhou Longlong 
Published: November 2022

AbstractThe origins of agriculture and pottery were generally believed to contribute to the changes of human food resources and the innovations of cooking technologies in the Neolithic China. Hence, the investigations of the co-evolutions in human food resources, cooking technologies and pottery functions will provide a new perspective for understanding the ancient social developments. Here, taking the Mijiaya site as an example, we present the multiple analyses on the plant microfossils of pottery remains, the AMS14C dating and isotopes of animal bones, and the types and textures of potteries in comparison with those from some surrounding sites in northern China during the Late Neolithic period. The results indicate that the diets of Mijiaya peoples (ca. 3093‒1961 cal BC) were heavily reliant on the diversified crops and livestock supplemented with some gathering plants and hunting animals; meanwhile, Mijiaya peoples used a variety of ways to refine the pottery functions for the complex food processing. Moreover, the food processing also potentially promoted the development in animal husbandry, basing on their feeding strategy and eating patterns. These preliminarily suggest that the coordinated development in the food, cooking and potteries had contributed to the social complexity in the Late Neolithic China.
Lifetime Extension of the High Voltage Asynchronous Machine in Relation to the Voltage Endurance Test
Authors: Brajović Dragan , Jokanović Bojan , Bebić Milan , Kartalović Nenad , Nikezic Dušan 
Published: November 2022

Abstract
The aim of the study is to achieve a simple, reliable and significant lifetime extension of the high voltage asynchronous machine in relation to the voltage endurance test. In order to achieve this goal, the focus was on achieving a longer-lasting and more stable insulation of the stator package of an asynchronous machine. Longer-lasting and more stable insulation of a stator is achieved by reinforcing the weak points on its prefabricated multiturn coils. These reinforcements were performed with standard insulating materials that are used for the production of the prefabricated multiturn coils (because of the fact that there is no data regarding the long-term behavior of new materials that show some better properties in laboratories, but only during short-term tests). With such reinforced weak spots on the basis of prefabricated models, they were made by the classical procedure with the use of standardized tools. In order to track the effects of the improvement of the insulation characteristics of a stator, an algorithm was developed based on the law of the increasing probability and on the determination of lifetime curves to the voltage endurance test. The lifetime curves were determined by the method of increasing voltage with the transformation of the obtained results to the corresponding results by the constant voltage method. The applied algorithm that was formed for the purpose of this study, had been verified with statistical reliability of 95 %. The combined measurement uncertainty of the measurement procedure was about 5 %.
There’s Some Whores In This House: An Examination of Female Sexuality in R&amp;B/Hip Hop and Pop Music, 1991–2021
Authors: Griffin Marybec , Fournet Adele , Zhai Angela , Mascary Dianney 
Published: November 2022

Abstract
Sexually explicit lyrics are more often expressed by male artists; however, sexually explicit lyrics created by female artists attract greater media interest. During the past thirty years, female-created lyrics about their sexuality have become increasingly more common and may serve as a ‘pink’-print used by adolescent and young women to construct their sexual identity. This study examines female sexuality as expressed in the lyrics of R&B/Hip Hop and Pop music by female artists between 1991–2021. These messages are marked by duality of female sexuality: respectability of the ‘good’ girl and expressing themselves as sexual beings with sexual desire.
Human Randomized Controlled Trail Clinical and Biochemical Evaluation Oral Irrigator Effectiveness in Patients Under Orthodontic Treatment
Authors: Şahin Esma , Cetinkaya Burcu Ozkan , Avci Bahattin , Kurt-Bayrakdar Sevda , Elekdag-Turk Selma 
Published: November 2022

Abstract
Objective

The aim of this study is to compare the effectiveness of oral irrigator (OI) with interdental brush (IB) clinically and biochemically in orthodontic patients.

Materials and Methods

Thirty patients were randomly divided into two equal groups; patients using OI in addition to manuel brushing (OI-group), patients using IB in addition to manual brushing (IB-group). The data was collected in the baseline, 2nd, 4th and 8th weeks. Periodontal indexes were recorded clinically and interleukin (IL)-1β, IL-10, matrix metalloproteinase (MMP)-1, MMP-8 levels in gingival crevicular fluid were evaluated biochemically.

Results

The gingival index and bleeding on probing values at the 8th week and plaque index values at the 2nd, 4th and 8th weeks were found to be statistically lower in the OI-group compared to IB-group. IL-1β total and concentration values at the 2nd week, MMP-8 total and concentration values at the 4th and 8th weeks were statistically lower in the OI-group compared to IB-group. There were no significant differences in MMP-1 and IL-10 total and concentration values between the groups at any time interval of the study.

Conclusions

The result of our study showed that usage of oral irrigator in addition to toothbrush appears to be as effective as interdental brush in patients under orthodontic treatment.

Clinical Revelance

There is limited information about OI’s using in orthodontic patients. The results of this study showed that oral irrigators can be used as an alternative oral care device for the interdental cleaning (NCT05562986).