bluuebunny/crossref_metadata_2025_split huggingface dataset:
Employee Performance Analysis Influenced by Leadership Style, Motivation and Work Discipline
Authors: Purnama Marselia , Hidayat Adrian , Angreni Tri 
Published: September 2022

This study aims to examine and analyze employee performance analysis which is influenced by leadership style, motivation and work discipline. The analytical method used in this study is a survey research method. The sampling technique in this study used a questionnaire. Data analysis used multiple regression analysis.
The results of this study note that the relationship of leadership style, motivation, and work discipline to employee performance. Beta value of leadership style 0.729 and 0.000 significance value <0.05. Leadership style has a significant relationship to employee performance. Beta value of motivation 0.191 and 0.028 significant value <0.05. Motivation has a significant relationship to employee performance. Beta value of work discipline 0.204 and 0.008 significance value <0.05. Work discipline has a significant relationship with employee performance. leadership style, motivation and work discipline have a significant relationship to employee performance together. The F statistic value is 57,258 with a significance of 0.000 < 0.05. Determination coefficient value 0.630
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE TEAM GAMES TOURNAMENT BERBANTUAN MEDIA PERMAINAN ULAR TANGGA UNTUK MENINGKATKAN KONSENTRASI DAN HASIL BELAJAR (Studi pada Mata Pelajaran IPA Siswa Kelas VII SMP Negeri 10 Lahat)
Authors: Syukurti Des 
Published: September 2022

This research aims to improve the concentration and student learning achievement of the implementation of cooperative learning model team games tournament Type with a media snakes game. Research subject of classroom action research (CAR) and quasi-experiment. This CAR is carried out in three cycles. The research subjects for this class action research were students of class VI of SMP Negeri 10 Lahat. Data collection techniques used were observation and tests. The data obtained were analyzed using the average formula and the interrelated t test and the unconnected t test. The results of this study indicate that the application of cooperative learning models of team games tournament assisted by snakes and ladders game can improve the concentration and learning outcomes of Grade VII students of SMP Negeri 10 Lahat so that it can be used in science learning.
PENGARUH MEDIA PEMBELAJARAN DAN GAYA KOGNITIF TERHADAP PRESTASI BELAJAR (Studi Eksperimen Pada Mata Pelajaran Kimia SiswaKelas XTO SMK Negeri 4 Kota Bengkulu)
Authors: Selvi Selvi , Wachidi Wachidi 
Published: September 2022

This research was aimed to discover the influence of the learning media (multimedia and real) and cognitive style (field independent and field dependent) toward the learning achievement. The population of this research was the students of XTO of SMKN 4 Bengkulu City for academic year of 2019/2020 on the five parallel grade of 162 students. The sample was taken by probability sampling technique. This research was conducted to 33 students of XTO3 as the experiment class which was using the media of multimedia learning and to the other 33 students of XTO4 as the control class which was using realia learning media. The design used in this research was factorial design (2 x 2) in which the data was analyzed by using the two-way ANOVA and t-Test variance. The results showed that: (1) the students with learning multimedia achievement were higher than them who were using the real learning media; (2) the students with the independent field cognitive style achievement were higher than them who have the dependent cognitive style; (3) there was an interaction between the use of learning media and the cognitive style to the learning achievement.
PENERAPAN MODEL STUDENT FACILITATOR AND EXPLAINING (SFAE) UNTUK MENINGKATKAN PRESTASI BELAJAR (Studi Pada Mata Pelajaran Ekonomi Siswa kelas X di SMA Negeri 1 Pagaralam)
Authors: Nurjana Meliza Ikke , Alexon Alexon 
Published: September 2022

Objectives of this study are to: (1improve student achievement by applying thelearning model Student Facilitator and Explaining (SFAE). (2) Increase the effectiveness of student learning outcomes by applying the Student Facilitator and Explaining (SFAE)model learningin Economics learning at SMA Negeri 1 Pagar Alam. In this study, classroom action research (CAR) was used with three cycles and experiments. The research subjects were students of class X IPS SMA Negeri 1 Pagar Alam. The data collection techniques used in the study were the observation sheets and student test results. The data analysis usedmeanand t-test. The conclusions of this research are; (1The application of themodel Student Facilitator and Explaining can improve student achievement based on the results (research on high school students Negeri 1 Pagar Alam in Economics). (2) The application of themodel is Student Facilitator and Explaining effectively used to improve student achievement (research on students of SMA Negeri 1 Pagar Alam in Economics).
APPLYING THE IMPLEMENTATION OF COOPERATIVE LEARNING TYPE MAKE A MATCH TO ENHANCE THE STUDENT’S COOPERATION AND LEARNING ACHIEVEMENT SPORTS STUDY (Research On Big Ball Game For Students Of X Class Nurse SMKN 4 Lebong)
Authors: Cahyadi Rachmad , Sapri Johanes 
Published: September 2022

The aim of this research is to enhance student’s cooperation and learning achievement in for Students of X Nurse SMKN 4 Lebong. The research subjects were 22 people students, 11 men and 11 women students. By applying the Implementation of Cooperative Type Make A Match Model. The kind of this research is classroom action research which was conducted in three cycles. Procedure used involves planning, Implementation, observation and reflection. The research instrument that had been used is the test namely the objective test which had been trial the validity and reliability of test and also the observation sheet for observation the learning activity of the students and teacher.To try the significance of student’s cooperation and learning achievement in first to third cycle, it is used t-test, and in first cycle the calculation gained tcount = 2,02. In second cycle the calculation gained ttable = 2,10. And in third cycle, the calculation gained tcount = 2,30 By comparing the tcount and ttable it is gained tcount > ttable namely 2,30 > 2,02. Thus, the learning achievement of Sport subject in the first post test at first cycle to third post test in second cycle is significance. So that the learning activity in first post test at first cycle and second post test second cycle is significance also.Based on the result it’s recommended to the teachers in applying the model of Make A Match type according to their owns situation.
Rancang Bangun Prototype Electrostatic Precipitator (ESP) Sebagai Penangkap Debu Asap Paska Pengelasan
Authors: Ningrum Hanifah Nur Kumala , Artono Budi , Haryo Raden Jasa Kusumo , Ardiansyah Soni Dwi 
Published: September 2022

Residu pengelasan berupa debu dan asap dapat diatasi dengan menggunakan electrostatic precipitator. Alat ini bekerja dengan memanfaatkan polarisasi partikel bermuatan positif (collecting plate) dan negatif ( dari discharge electrode). Ion negatif setelah melewati jaring dan tertarik kedalam plate yang bermuatan positif. Perancangan ini meliputi pembangkit tegangan tinggi DC dan perancangan box penyaringan asap. Pembangkit tenaga tinggi DC pada alat ini menggunakan metode pengali tegangan cockroft – walton 2 tingkat dan 4 tingkat. Kapasitor yang digunakan adalah tipe 1
Salvianolic acid B combined with bone marrow mesenchymal stem cells piggybacked on HAMA hydrogel re-transplantation improves intervertebral disc degeneration
Authors: Hu Jie , Li Cai , Jin Shichang , Ye Yuchen , Fang Yuekun , Xu Panpan , Zhang Changchun 
Published: September 2022

Cell-based tissue engineering approaches have emerged as a realistic alternative for regenerative disc tissue repair. The multidirectional differentiation potential of bone marrow mesenchymal stem cells (BMSCs) to treat disc degeneration intervertebral disc degeneration has also become a viable option. We used 1% HAMA hydrogel as a carrier and co-encapsulated BMSCs and Salvianolic acid B (SalB) into the hydrogel to reduce the apoptosis of the transplanted cells. The protective effect of SalB on BMSCs was first verified in vitro using the CCK8 method, flow cytometry, and Western-Blotting, and the physical properties and biocompatibility of HAMA hydrogels were verified in vitro. The rat model was then established using the pinprick method and taken at 4 and 8 W, to examine the extent of disc degeneration by histology and immunohistochemistry, respectively. It was found that SalB could effectively reduce the apoptosis of BMSCs in vitro by activating the JAK2-STAT3 pathway. 1% HAMA hydrogels had larger pore size and better water retention, and the percentage of cell survival within the hydrogels was significantly higher after the addition of SalB to the HAMA hydrogels. In the in vivo setting, the HAMA + SalB + BMSCs group had a more pronounced delaying effect on the progression of disc degeneration compared to the other treatment groups. The method used in this study to encapsulate protective drugs with stem cells in a hydrogel for injection into the lesion has potential research value in the field of regenerative medicine.
Mechanical properties of tunneling nanotube and its mechanical stability in human embryonic kidney cells
Authors: Li Aoqi , Han Xiaoning , Deng Linhong , Wang Xiang 
Published: September 2022

Tunneling nanotubes (TNTs) are thin membrane tubular structures that interconnect physically separated cells. Growing evidence indicates that TNTs play unique roles in various diseases by facilitating intercellular transfer of signaling and organelles, suggesting TNTs as a potential target for disease treatment. The efficiency of TNT-dependent communication is largely determined by the number of TNTs between cells. Though TNTs are physically fragile structures, the mechanical properties of TNTs and the determinants of their mechanical stability are still unclear. Here, using atomic force microscope (AFM) and microfluidic techniques, we investigated the mechanical behavior and abundance of TNTs in human embryonic kidney (HEK293) cells upon the application of forces. AFM measurements demonstrate that TNTs are elastic structures with an apparent spring constant of 79.1 ± 16.2 pN/μm. The stiffness and membrane tension of TNTs increase by length. TNTs that elongate slower than 0.5 μm/min display higher mechanical stability, due to the growth rate of F-actin inside TNTs being limited at 0.26 μm/min. Importantly, by disturbing the cytoskeleton, membrane, or adhesion proteins of TNTs, we found that F-actin and cadherin connection dominantly determines the tensile strength and flexural strength of TNTs respectively. It may provide new clues for screening TNT-interfering drugs that alter the stability of TNTs.
Facile hydrothermal synthesis of layered 1T′ MoTe2 nanotubes as robust hydrogen evolution electrocatalysts
Authors: Lei Yuxi , Xiao Xuefeng , Ma Tianpeng , Li Weiyin , Zhang Huan , Ma Chao 
Published: September 2022

Layered transition metal dichalcogenides (TMDs), such as molybdenum ditelluride (MoTe2), have attracted much attention because of their novel structure-related physicochemical properties. In particular, semi-metallic-phase MoTe2 (1T′) is considered as a competitive candidate for low-cost electrocatalysts for water splitting. However, there are few reports on the simple hydrothermal synthesis of MoTe2 nanostructures compared with other layered TMDs. In this study, a facile one-step hydrothermal process was developed for the fabrication of layered MoTe2, in which uniform nanotubes with a few layers of 1T′ MoTe2 were fabricated at a lower temperature for the first time. The as-obtained MoTe2 nanotubes were fully characterized using different techniques, which revealed their structure and indicated the presence of layered 1T′ nanocrystals. The efficient activity of MoTe2 nanotubes for the electrocatalytic hydrogen evolution reaction (HER) in 0.5 M H2SO4 was demonstrated by the small Tafel slope of 54 mV/dec−1 and endurable ability, which is attributed to the abundant active sites and remarkable conductivity of 1T′ MoTe2 with a few-layer feature. This provides a facile method for the design and construction of efficient layered MoTe2 based electrocatalysts.
Identification and mechanism prediction of mulberroside A metabolites in vivo and in vitro of rats using an integrated strategy of UHPLC-Q-Exactive Plus Orbitrap MS and network pharmacology
Authors: Zhang Xiao , Dong Pingping , Song Jian , Zhang Huimin , Wang Feiran , Liu Yuecheng , Yan Yingying , Li Linlin 
Published: September 2022

Mulberroside A is a polyhydroxylated stilbene active component of Morus alba L. Studies have shown that it has antitussive, antiasthmatic, tyrosinase and antioxidation activities. However, little is known about the metabolism of it in vitro and in vivo. In our study, an integrated strategy on the basis of UHPLC-Q-Exactive Plus Orbitrap MS and network pharmacology was established to comprehensively research the metabolic characteristic of mulberroside A for the first time. Plasma, urine, feces and liver tissues of rats in the blank group and drug group were collected after intragastric administration of mulberroside A at a dose of 150 mg/kg, and rat liver microsomes were cultured for in vitro metabolism experiment. The biological samples were processed by different methods and analyzed in positive and negative ion modes using UHPLC-Q-Exactive Plus Orbitrap MS. A total of 72 metabolites were finally identified based on the accurate molecular mass, retention time, MS/MS spectra and related literatures combined with the Compound Discoverer 3.1. The metabolic pathways were mainly hydrolysis, glucuronidation, hydrogenation, sulfation, hydroxylation, methylation and their composite reactions. In addition, a network pharmacology method was used to predict the mechanism of action of mulberroside A and its metabolites. In the end, 7 metabolites with high gastrointestinal absorption and drug-likeness and 167 targets were screened by Swiss ADME and Swiss Target Prediction. 1702 items of GO analysis and 158 related signaling pathways of KEGG were enriched using Metascape. This study established a novel integrated strategy based on UHPLC-Q-Exactive Plus Orbitrap MS and network pharmacology, which could systematically analyze the metabolism behavior of mulberroside A in vivo and in vitro of rats and provide basis for the further research of mulberroside A.
Altered gut microbiota and gut-derived p-cresyl sulfate serum levels in peritoneal dialysis patients
Authors: Bao Manchen , Zhang Pan , Guo Shulan , Zou Jianzhou , Ji Jun , Ding Xiaoqiang , Yu Xiaofang 
Published: September 2022

Peritoneal dialysis (PD) is a renal replacement therapy for end-stage renal disease. Gut microbiota-derived uremic solutes, indoxyl sulfate (IS), p-cresyl sulfate (PCS), and trimethylamine-N-oxide (TMAO) accumulate in PD patients. The objective was to explore the gut microbiota and their influence on uremic toxins in PD patients and healthy controls (HC). Fecal samples were collected from PD patients (n = 105) and HC (n = 102). 16S rRNA gene regions were sequenced for gut microbiota analysis. IS, PCS, and TMAO levels were measured using HPLC-MS. PD patients exhibited lower alpha diversity and altered gut microbiota composition compared to HC. At the genus level, PD patients showed increased abundance of opportunistic pathogenic bacteria, and decreased abundance of beneficial bacteria. Three Operational Taxonomic Units discriminated PD patients from HC. Phenylalanine metabolism increased in PD, whereas tryptophan metabolism was unaltered. Low serum PCS did not necessarily mean healthier due to the loss of alpha diversity, increased Proteobacteria and opportunistic pathogenic bacteria. High serum PCS was mainly caused by elevated p-cresol-producing bacteria, enriched amino acid related enzymes, and enhanced sulfur metabolism, rather than declined residual renal function. In patients with different urine volumes, the gut microbiota alpha diversity and composition were unaltered, but serum IS and TMAO were significantly elevated in anuric patients. In conclusion, the gut microbiota abundance, composition, and function were altered in PD patients, which increased the PCS levels. We provided a better understanding of the microbiota-metabolite-kidney axis in PD patients. Targeting certain bacteria could decrease the PCS levels, whereas preserving the residual renal function could reduce the IS and TMAO levels.
In-hospital arrhythmic burden reduction in diabetic patients with acute myocardial infarction treated with SGLT2-inhibitors: Insights from the SGLT2-I AMI PROTECT study
Authors: Cesaro Arturo , Gragnano Felice , Paolisso Pasquale , Bergamaschi Luca , Gallinoro Emanuele , Sardu Celestino , Mileva Niya , Foà Alberto , Armillotta Matteo , Sansonetti Angelo , Amicone Sara , Impellizzeri Andrea , Esposito Giuseppe , Morici Nuccia , Oreglia Jacopo Andrea , Casella Gianni , Mauro Ciro , Vassilev Dobrin , Galie Nazzareno , Santulli Gaetano , Pizzi Carmine , Barbato Emanuele , Calabrò Paolo , Marfella Raffaele 
Published: September 2022

BackgroundSodium-glucose co-transporter 2 inhibitors (SGLT2-i) have shown significant cardiovascular benefits in patients with and without type 2 diabetes mellitus (T2DM). They have also gained interest for their potential anti-arrhythmic role and their ability to reduce the occurrence of atrial fibrillation (AF) and ventricular arrhythmias (VAs) in T2DM and heart failure patients.ObjectivesTo investigate in-hospital new-onset cardiac arrhythmias in a cohort of T2DM patients presenting with acute myocardial infarction (AMI) treated with SGLT2-i vs. other oral anti-diabetic agents (non-SGLT2-i users).MethodsPatients from the SGLT2-I AMI PROTECT registry (NCT05261867) were stratified according to the use of SGLT2-i before admission for AMI, divided into SGLT2-i users vs. non-SGLT2-i users. In-hospital outcomes included the occurrence of in-hospital new-onset cardiac arrhythmias (NOCAs), defined as a composite of new-onset AF and sustained new-onset ventricular tachycardia (VT) and/or ventricular fibrillation (VF) during hospitalization.ResultsThe study population comprised 646 AMI patients categorized into SGLT2-i users (111 patients) and non-SGLT2-i users (535 patients). SGLT2-i users had a lower rate of NOCAs compared with non-SGLT2-i users (6.3 vs. 15.7%, p = 0.010). Moreover, SGLT2-i was associated with a lower rate of AF and VT/VF considered individually (p = 0.032). In the multivariate logistic regression model, after adjusting for all confounding factors, the use of SGLT2-i was identified as an independent predictor of the lower occurrence of NOCAs (OR = 0.35; 95%CI 0.14–0.86; p = 0.022). At multinomial logistic regression, after adjusting for potential confounders, SGLT2-i therapy remained an independent predictor of VT/VF occurrence (OR = 0.20; 95%CI 0.04–0.97; p = 0.046) but not of AF occurrence.ConclusionsIn T2DM patients, the use of SGLT2-i was associated with a lower risk of new-onset arrhythmic events during hospitalization for AMI. In particular, the primary effect was expressed in the reduction of VAs. These findings emphasize the cardioprotective effects of SGLT2-i in the setting of AMI beyond glycemic control.Trial registrationData are part of the observational international registry: SGLT2-I AMI PROTECT. ClinicalTrials.gov, identifier: NCT05261867.
First peripheral drug-eluting stent clinical results from China: 1-year outcomes of the Zilver PTX China study
Authors: Ye Wei , Böhme Tanja , Fu Weiguo , Liu Changwei , Zhang Xiaoming , Liu Peng , Zhang Jiwei , Zou Yinghua , Lu Xinwu , Lottes Aaron E. , O'Leary Erin E. , Zeller Thomas , Dake Michael D. 
Published: September 2022

PurposeThe benefit of using the Zilver PTX drug-eluting stent (DES) in superficial femoral artery (SFA) lesions has been demonstrated in multiple clinical studies. This prospective, multicenter study evaluated the 1-year safety and effectiveness of the DES for the treatment of femoropopliteal lesions in a Chinese patient population.MethodsPatients with a single de novo or restenotic SFA lesion ≤140 mm and a Rutherford classification of 2 to 4 were treated with the DES. The primary endpoint was primary patency assessed by duplex ultrasound at 1-year. Secondary endpoints included adverse events, event-free survival (EFS), and freedom from target lesion revascularization (TLR). Clinical outcomes included Rutherford classification, ankle-brachial index (ABI), and the walking impairment questionnaire (WIQ).ResultsIn this study, 178 patients with symptomatic peripheral artery disease were enrolled at nine institutions in China. The average lesion length was 79.0 ± 48.6 mm (range 14.8–245.4 mm) and 50.0% of lesions were total occlusions. The 1-year primary patency rate was 81.9%. Covariate analysis revealed that lesion length (p &lt; 0.01) was the only significant factor for patency. No paclitaxel-related adverse events or amputations were reported. The 1-year rate for EFS was 94.9% and freedom from TLR was 95.5%. Through 1-year, treatment with the DES resulted in statistically significant improvement in ABI and WIQ scores compared with pre-procedure (p &lt; 0.001). Clinical improvement of at least 1 Rutherford class was achieved in 142 of 174 patients (81.6%).ConclusionThis study showed promising short-term results for the treatment of SFA lesions with Zilver PTX DES in Chinese patients.Unique identifierClinicalTrials.gov, identifier: NCT02171962.
A simulation study on the climatic responses to short-lived climate pollutants changes from the pre-industrial era to the present
Authors: Xie B. , Zhang H. 
Published: September 2022

Short-lived climate pollutants (SLCPs) including methane, tropospheric ozone, and black carbon in this work, is a set of compounds with shorter lifetimes than carbon dioxide (CO2) and can cause warming effect on climate. Here, the effective radiative forcing (ERF) is estimated by using an online aerosol–climate model (BCC_AGCM2.0_CUACE/Aero); then the climate responses to SLCPs concentration changes from the pre-industrial era to the present (1850–2010) are estimated. The global annual mean ERF of SLCPs was estimated to be 0.99 [0.79–1.20] W m−2, and led to warming effects over most parts of the globe, with the warming center (about 1.0 K increase) being located in the mid-high latitudes of the Northern Hemisphere (NH) and the ocean around Antarctica. The changes in annual mean surface air temperature (SAT) caused by SLCPs changes were more prominent in the NH [0.78 (0.62–0.94) K] than in the Southern Hemisphere [0.62 (0.45–0.74) K], and the global annual mean value is 0.70 K. By looking at other variable responses, we found that precipitation had been increased by about 0.10 mm d−1 in mid- and high-latitudes and decreased by about 0.20 mm d−1 in subtropical regions, with the global annual mean value of 0.02 mm d−1. Changes in SLCPs also influenced atmospheric circulation change, a northward shift in the Intertropical Convergence Zone was induced due to the interhemispheric asymmetry in SAT. However, it is found in this work that SLCPs changes had little effect on global average cloud cover, whereas the local cloud cover changes could not be ignored, low cloud cover increase by about 2.5% over high latitudes in the NH and the ribbon area near 60°S, and high cloud cover increased by more than 2.0% over northern Africa and the Indian Ocean. Finally, we compared the ERFs and global and regional warming effects of SLCPs with those induced by CO2 changes. From 1850 to the present, the ERF of SLCPs was equivalent to 66%, 83%, and 50% of that of CO2 in global, NH, and SH mean, respectively. The increases in SAT caused by SLCPs were 43% and 55% of those by CO2 over the globe and China, respectively.