bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of adverse events varies with the different oral isotretinoin brands in acne treatment: a retrospective observational study.
Authors: Soutou Boutros , Sleiman Joelle , Tomb Roland , Kechichian Elio , Helou Josiane 
Published: August 2022

Abstract
Oral isotretinoin remains the most effective treatment for acne. The aim of this retrospective single-center cohort study was to estimate the prevalence of adverse events with the different oral isotretinoin brands used in acne treatment. The population consisted of all patients who consulted for acne between January 2015 and January 2020. The inclusion criterion was the initiation of treatment with oral isotretinoin. The exclusion criteria were the use of two or more brands during the same course of treatment and previous treatment with oral isotretinoin. Statistical analysis was carried out using Chi-square and Mann-Whitney tests. We analyzed 468 patients of whom 68.6% were female. The median age was 21 years. The median weight was 65 kg. The treatment was Roaccutane®, Curacné®, Acnotren®, Isosupra®, Contracné®, or Acnogen® in 44.2%, 28%, 14.5%, 10.5%, 1.7% and 0.4% of cases, respectively. Xerosis was the most frequently reported side effect regardless of the brand. The highest frequencies of: - hypercholesterolemia (25.6%) and eczema (13%) were noted with Roaccutane®; - hypertriglyceridemia (16.8%), epistaxis (9.9%) and fatigue (3.1%) with Curacné®; - excessive sweating (4.1%) and headache (4.1%) with Isosupra®; - abnormal liver function tests (11%) with Acnotren®. We found a significant correlation mainly between abnormal ASAT and Acnotren®(p = 0.009), hypercholesterolemia and Roaccutane® [OR = 1.652 (95%CI: 1.056–2.585)], hypertriglyceridemia and higher body weight (p = 0.004). Factors related to the drug brand and to characteristics of acne patients could explain the variability in the prevalence of some adverse events.
Pancreaticoduodenectomy with celiac artery resection (PD-CAR) for locally advanced pancreatic ductal adenocarcinoma Name of the authors
Authors: Kimura Kenjiro , Amano Ryosuke , Tauchi Jun , Nishio Kohei , Ohira Go , Shinkawa Hiroji , Tanaka Shogo , Yamamoto Akira , Motomura Hisashi , Ishizawa Takeaki 
Published: August 2022

Abstract
Purpose
Locally advanced pancreatic ductal adenocarcinoma (LA-PDAC) involving the celiac artery (CeA), the common hepatic artery and the gastroduodenal artery (GDA) is considered unresectable. We developed the novel procedure of pancreaticoduodenectomy with celiac artery resection (PD-CAR) for such LA-PDACs.
Methods
From 2015 to 2018, we performed curative pancreatectomy with major arterial resection for 13 LA-PDACs as a clinical study (UMIN000029501). Of those, four patients with pancreatic neck cancer involving the CeA and GDA were candidates for PD-CAR. Prior to surgery, blood flow alterations were performed to unify the blood flow to the liver, stomach, and pancreas, resulting in feeding from the cancer-free artery. During PD-CAR, arterial reconstruction of the unified artery was performed as needed. Based on the records of PD-CAR cases, we retrospectively analyzed the validity of the operation.
Results
R0 resection was achieved in all patients. Arterial reconstruction was performed in three patients. In another patient, the hepatic arterial flow was maintained by preserving of the left gastric artery. The mean operative time was 669 min and the mean blood loss was 1003 g. Although Clavien-Dindo classification III-IV postoperative morbidities occurred in three patients, no reoperations nor mortalities occurred. Although two patients died of cancer recurrence, one patient survived for 26 months without recurrence (died of cerebral infarction), and another is alive at 76 months without recurrence.
Conclusion
PD-CAR, which enabled R0 resection and preservation of the residual stomach, pancreas, and spleen, provided acceptable postoperative outcomes.
Early Mitochondrial Defects in the 5xFAD mouse model of Alzheimer’s Disease
Authors: Sharma Neelam , Banerjee Rupkatha , Davis Ronald L. 
Published: August 2022

Abstract
BACKGROUND
Mitochondrial (MT) dysfunction is a hallmark of Alzheimer’s disease (AD). Amyloid Precursor Protein and Aβ peptides localize to MT and lead to MT dysfunction in familial forms of AD. This dysfunction may trigger subsequent types of pathology. Identification of the MT phenotypes that occur early is required to help understand the cascade of AD pathophysiology.
METHODS
The 5xFAD mouse model was used to explore the time course of MT pathologies in both sexes. Protein biomarkers for MT dynamics were measured biochemically and MT function was measured using oxygen consumption and ATP assays.
RESULTS
We discovered progressive alterations in mitochondrial dynamics (biogenesis, fission, fusion, and mitophagy) and function (O2 consumption, ATP generation, and Ca2+ import) in the hippocampus of 5xFAD mice in both sexes as early as 2 month-of-age. Thus, mitochondrial dynamics and function become altered at young ages, consistent with an early role for mitochondria in the AD pathological cascade.
CONCLUSIONS
Our study offers the baseline information required to understand the hierarchical relationship between the multiple pathologies that develop in this mouse model and provides early biomarkers for MT dysfunction. This will aid in dissecting the temporal cascade of pathologies, understanding sex-specific differences, and in testing the efficacy of putative mitochondrial therapeutics.
Blockchain in Financial Services: Current Status, Adaptation Challenges, and Future Vision
Authors: Mia Anisha , Rahouti Mohamed , Jagatheesaperumal Senthil Kumar , Ayyash Moussa , Xiong Kaiqi , Fernandez Fredery , Lekena Modupe 
Published: August 2022

Abstract
Blockchain is undoubtedly considered one of the most innovative technologies in financial services from the past decade. Interests in blockchain technology continue to grow on a daily basis, while many promising blockchain-enabled applications and services continue to draw financial interests in the industrial sector and the broader financial services communities. Furthermore, as blockchain matures, it increases the value of a diversified range of industries and institutes with a better return on investment. However, such organizations must continue to adopt rigorous approaches to enhance their financial services and regulate their policies. In this article, we discuss the current status of blockchain-enabled financial services and applications, in addition to the impacts, implications, and regulations of incorporating blockchain technology in the finance industry. We further tackle the adaptation model for blockchain technology in global banking and provide a vision for the next generation of financial services based on this emerging technology.
Postoperative complications and oncologic outcomes after multimodal therapy of localized high risk soft tissue sarcoma
Authors: Potkrajcic Vlatko , Kolbenschlag Jonas , Sachsenmaier Saskia , Daigeler Adrien , Ladurner Ruth , Golf Alexander , Zips Daniel , Paulsen Frank , Eckert Franziska 
Published: August 2022

Abstract
Background
Standard therapy for localized high-risk soft tissue sarcoma includes surgical resection and neoadjuvant or adjuvant radiation therapy (+/-chemotherapy and locoregional hyperthermia). No difference in oncologic outcomes for patients treated with neoadjuvant and adjuvant radiation therapy was reported, whereas side effect profiles differ. The aim of this analysis was to analyse oncologic outcomes and wound healing complications in patients treated with multimodal treatment.
Methods
Oncologic outcomes and major wound complications (MWC, subclassified as wound healing disorder, infection, abscess, fistula, seroma and hematoma) were evaluated in all 84 patients with localized high-risk soft tissue sarcoma undergoing multimodal treatment, and also separately for the subgroup of lower extremity tumors. Clinical factors and treatment modalities (especially neoadjuvant versus adjuvant radiotherapy) were evaluated regarding their prognostic value and impact on postoperative wound complications.
Results
Oncologic outcome was dependent on tumor localization (worse for retroperitoneal sarcomas) and number of high risk features (tumor size, depth to superficial fascia and grading), but not on therapy sequencing (however with higher risk patients in the neoadjuvant group). Different risk factors influenced different subclasses of wound healing complications. No difference in MWC-rate in the whole cohort was found between patients treated with neoadjuvant and adjuvant radiation therapy (31.4% vs. 18.2%, p = 0.168). Except for wound infections, no significant differences were observed between neoadjuvant and adjuvant therapy. Diabetes was confirmed as a major risk factor for immune-related wound complications.
Conclusion
Rates of major wound complications in this cohort are comparable to published data, higher rates of wound infections were observed after neoadjuvant radiotherapy. Patient age and diabetes seem to be major risk factors. The number of risk factors for high risk soft tissue sarcoma seem to influence oncologic outcomes. Neoadjuvant treatment increases the risk only for wound infection treated with oral or intravenous antibiotic therapy and appears to be a safe option at an experienced tertiary center in absence of other risk factors.
A randomised controlled feasibility study of food-related computerised attention training versus mindfulness training and waiting-list control for adults with overweight or obesity: the FOCUS study
Authors: Mercado Daniela , Werthmann Jessica , Antunes-Duarte Tiago , Campbell Iain C , Schmidt Ulrike 
Published: August 2022

Abstract
Background: In a feasibility randomised controlled trial (RCT) in people with overweight/obesity with and without binge eating disorder (BED) symptoms, we assessed eight weekly sessions of attention bias modification training (ABMT) and mindfulness training (MT) versus waiting list (WL) and explored potential mechanisms. Methods: 45 participants were randomly allocated to one of three trial arms. Primary outcomes were recruitment, retention and treatment adherence rates. Secondary outcomes included measures of eating behaviour, mood, attention and treatment acceptability. Assessments were conducted at baseline, post-intervention (week 8), and follow-up (week 12). Results: Participant retention at follow-up was 84.5% across groups. Session completion rates in the laboratory were 87% for ABMT and 94% for MT, but home practice was much poorer for ABMT. Changes in BMI and body composition were small between groups and there was a medium size BMI reduction in the MT group at follow-up. Effect sizes of eating disorder symptom changes were not greater for either intervention group compared to WL, but favoured ABMT compared to MT. Hedonic hunger and mindful eating scores favoured MT compared to ABMT and WL. ABMT reduced attention biases towards high-calorie food cues, which correlated with lower binge eating episodes at post-intervention. No significant changes were observed in the MT, or WL conditions. Conclusions: Both ABMT and MT have potential value as adjuncts in the treatment of obesity and BED, and a larger clinical trial appears feasible and indicated. Trial registration: ISRCTN Registry, ISRCTN15745838. Registered on 22 May 2018.
Distribution of southern tomato virus in tomato tissues
Authors: Hao Xiaojun , Zheng Yinying , Cui Baiming , Xiang Benchun 
Published: August 2022

Abstract
Southern tomato virus (STV) is a dsRNA virus, which belongs to the newly formed Amalgavirus genus of the Amalgaviridae family. Up to now, there is no report on the presence of STV in tomato tissues. In this study, we performed in situ hybridization to examine the distribution of STV in host tissues. The STV was found in the leaves, stems, seeds, shoot apexes and root tips of tomato and localized in the cortex tissue, vascular tissues, pith, seed coat, endosperm, cotyledon (including inner cotyledons and outer cotyledons), hypocotyls and radicles of infected tomato tissues. In addition, STV was detected in the apical part of the stems and roots for the first time. This indicates that STV is a systemic infection disease for tomato.
Microcrack segmentation of 3D CT images based on multi-task learning
Authors: Peng Junjie , Li Wenbin , Liao Suyu , Xu Tao , Zhu Yining 
Published: August 2022

Abstract

As a non-destructive testing technique, industrial CT (Computed Tomography) plays an important role in research and applications of the automatic defect detection for 3D CT images. In recent years, convolutional neural networks (CNNs) have shown great potential in image recognition and segmentation tasks. For industrial 3D CT image detection, how to segment microstructural cracks is the main task at present. The challenge of this task is to identify cracks with low grayscale contrast and small size under unbalanced sample conditions. To address these problems, we propose a crack segmentation method based on the multi-task deep convolutional neural networks. The network architecture consists of a segmentation task module for extracting cracks and a classification task module for improving accuracy, which share part feature maps. We introduce the ECA block based on attention mechanism from Chen et al. to improve the segmentation accuracy. Numerical experimental results show that the proposed method has the better performance compared with other methods. At the same time, the network proposed in this paper has good generalization ability. In the case of only using simulated images training, it still yields good prediction results for real CT images.
Clear cell renal cell carcinoma with cystic component similar to multilocular cystic renal neoplasm of low malignant potential: a rare pattern of cyst-dependent progression from multilocular cystic renal neoplasm of low malignant potential
Authors: Yang Bo , Sun Lin , Cao Wen-feng , Qi Li-sha , Guo Yu-hong , Sun Yan 
Published: August 2022

Abstract
Background: For clear cell renal cell carcinoma (ccRCC) with cystic component similar to multilocular cystic renal neoplasm of low malignant potential (MCRN-LMP) and solid low-grade component simultaneously, we propose the designation “ccRCC with cystic component similar to MCRN-LMP” and to study the relationship between MCRN-LMP and it. Methods: Twelve cases of MCRN-LMP and 33 cases of ccRCC with cystic component similar to MCRN-LMP were collected from 3,265 consecutive RCCs to compare them in clinicopathological features, immunohistochemical findings (PAX8, CA-IX, CK7, Vimentin, CD10, P504s, TFE3, 34βE12) and prognosis. Results: There was no significant difference in age, sex ratio, tumor size, treatment, grade and stage between them (P > 0.05). All ccRCCs with cystic component similar to MCRN-LMP coexisted with MCRN-LMP and solid low-grade ccRCCs, and MCRN-LMP component ranged from 20% to 90% (median, 59%). The positive ratio of CK7 and 34βE12 in MCRN-LMPs and ccRCCs’ cystic parts was significantly higher than that in ccRCCs’ solid parts, but the positive ratio of CD10 in MCRN-LMPs and ccRCCs’ cystic parts was significantly lower than that in ccRCCs’ solid parts (P < 0.05). There was no significant difference of all immunohistochemistry profiles between MCRN-LMPs and ccRCCs’ cystic parts (P > 0.05). No patient developed recurrence or metastasis. Conclusions: MCRN-LMP and ccRCC with cystic component similar to MCRN-LMP have similarity and homology in clinicopathological features, immunohistochemical findings and prognosis, and form a low-grade spectrum with indolent or low malignant potential behavior. The ccRCC with cystic component similar to MCRN-LMP may be a rare pattern of cyst-dependent progression from MCRN-LMP.
Flip bifurcation and Neimark-Sacker bifurcation in a discrete predator-prey model with Michaelis-Menten functional response
Authors: Li Xianyi , Shao Xingning 
Published: August 2022

Abstract
In this paper, we use a semi-discretization method to explore a predator-prey model with Michaelis-Menten functional response. Firstly we investigate the existence and local stability of fixed points. Then by using the center manifold theorem and bifurcation theory, we demonstrate that the system experiences a flip bifurcation and a Neimark-Sacker bifurcation at a fixed point when one of the parameters goes through its critical value. To illustrate our results, numerical simulations, which include maximum Lyapunov expoents, fractal dimensions and phase portraits, are also presented.
A Reliable Numerical Treatment of Differential Equations via Hybrid Bernstein and Improved Block-Pulse Functions
Authors: Ramadan Mohamed A. , Osheba Heba S. 
Published: August 2022

Abstract
Recently, the authors attempted to solve integral equations using hybrid improved block pulse and Bernstein functions. However, this is the first article to present a technical coupling between improved block-pulse functions and Bernstein functions for solving differential equations. The current method converts differential equations into an algebraic system that can be solved using traditional methods. To demonstrate the validity of this new approach, some numerical tests are provided. The findings demonstrated that the method is both promising and highly accurate.
Increased Metallothionein-1 associated with gout activity and tophi
Authors: Ma Yanmei , Yin Zhihua , Dai Hanying , Cong Junxiao , Wu Dandan , Huang Xinmin , Chen Xinpeng , Zou Linghua , Ye Zhizhong , Huang Zhong 
Published: August 2022

Abstract
Introduction：Gout is a chronic self-limiting inflammatory arthritis. The mechanism for the spontaneous rapid resolution of inflammation in acute gout was not yet to be elucidated. Metallothionein-1(MT-1) belongs to the metallothionein family, it has been reported to increase in rheumatoid arthritis (RA) and osteoarthritis (OA), and attenuate the inflammation and pathology of the diseases, however the expression of MT-1 in gout and the correlation with the disease activity are still unclear. The present study aims to detect the level of MT-1 in gout patients, and to explore its correlation with disease activity, complication, clinical indexes and inflammatory cytokines.Methods：The expressions of MT-1 mRNAs in PBMCs and serum MT-1 levels in gout patients were measured by real-time polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). The correlations between MT-1 and clinical indexes or inflammatory mediators in serum of gout were analyzed by Spearman correlation test.Results：Compared to healthy controls (HCs), active gout patients showed higher levels of MT-1 mRNA in PBMCs and protein in serum, especially in active gout patients with tophi. No significant difference in serum MT-1 levels was observed among the inactive gout patients, HCs and hyperuricemia patients without gout, and also no significant difference was found between kidney damage gout patients and HCs. Compared to HCs, serum IL-1β, IL-6 and IL-8 levels were significant elevated in active gout patients, especially in active gout patients with tophi. Serum MT-1 were positively correlated with CRP, as well as with IL-1β, IL-6 and IL-18, but not correlated with urid acid (UA), ESR and CREA in gout patients. Conclusion：MT-1 was up-regulated in active gout patients, especially in active gout patients with tophi, and positively associated with CRP, as well as with proinflammatory cytokine IL-1β, IL-6 and IL-8. Given that MT-1 has anti-inflammatory, anti-oxidative stress capacity in chronic noninfectious inflammatory diseases, thus, elevated MT-1 in active gout patients may play as an immune mediator to suppress the inflammatory response in acute gout episode.
Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
Authors: Khanna Kum Kum , Rashidieh Behnam , Bain Amanda , Tria Simon , Sharma Sowmya , Stewart Cameron , Simmons Jacinta , Apaja Pirjo , Duijf Pascal , Finnie John 
Published: August 2022

Abstract
αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers. Previous studies using human cancer cell lines and human xenograft models have reported tumor suppressor or tumor promoter (oncogene) roles for αB-Crystallin depending on cellular context and environmental conditions. To determine the causal relationship between CRYAB overexpression and cancer, we generated a Cryab overexpression knock-in mouse model. This model revealed that constitutive overexpression of Cryab results in the formation of a variety of lethal spontaneous primary and metastatic tumors in mice. In vivo, the overexpression of Cryab correlated with the upregulation of epithelial-to-mesenchymal (EMT) markers, angiogenesis and some oncogenic proteins including Basigin. In vitro, using E1A/Ras transformed mouse embryonic fibroblasts (MEFs), we observed that the overexpression of Cryab led to the promotion of cell survival via upregulation of Akt signaling and downregulation of pro-apoptotic pathway mediator JNK, with subsequent attenuation of apoptosis as assessed by cleaved caspase-3. Overall, through the generation and characterization of Cryab overexpression model, we provide evidence supporting the role of αB-Crystallin as an oncogene, where its upregulation is sufficient to induce tumors, promote cell survival and inhibit apoptosis.
Depression in primary care and the role of evidence-based guidelines: Cross- sectional data from primary care physicians in Germany
Authors: Lech Sonia , Herrmann Wolfram , Trautmann Sebastian , Schwantes Ulrich , Gellert Paul , Behr Joachim , Buspavanich Pichit 
Published: August 2022

Abstract
Background: Depression is the most common mental health burden worldwide. Primary care physicians (PCPs) play a key role in the care provision for people with depression. The main objective of the present study was to examine the health care situation of depression in primary care, focusing on the cooperation between PCPs and mental health specialists, as well as the role of the German S3 Guideline for Unipolar Depression in the primary care provision. Methods: Cross-sectional data of N = 85 PCPs obtained from an online survey was analysed. Analysis of descriptive information on the current status of primary health care and depression was conducted. Further, to examine factors that are related to the usage of guidelines, multiple regression was performed. Results: Only 22.1% of PCPs described the quality of cooperation with ambulatory mental health specialist as good. The most frequent problems in the cooperation were of structural nature (49.3%, long waiting list, few therapy units, as well as barriers in the communication and the information exchange). With regard to the role of the guideline, 65% of PCPs reported never or seldom using the guideline and 31.7% of PCPs perceived the guideline as not useful at all. In addition, perceived usefulness of the S3 guideline were positively associated with the usage of the guideline. Results of the logistic regression revealed a significant association between the usage of the German S3 Guideline for Unipolar Depression and rating of perceived usefulness of the guideline (OR: 4.771; 95% CI: 2.15-10.59; p < 0.001).Conclusion: This study highlights the central role of PCPs and demonstrates major barriers in the outpatient health care provision of depression. Present findings suggest a strong need for collaborative health care models to resolve obstacles resulting from fragmented mental health care systems. Finally, reported perceived barriers in the implementation of the German S3 Guideline for Unipolar Depression indicate the urge to involve PCPs in the development of evidence-based guidelines, in order to ensure a successful implementation and usage of guidelines in clinical practice.