bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of obesity on post-operative arrhythmias after congenital heart surgery in children and young adults
Authors: Radbill Andrew E. , Smith Andrew H. , Van Driest Sara L. , Fish Frank A. , Bichell David P. , Mettler Bret A. , Christian Karla G. , Edwards Todd L. , Kannankeril Prince J. 
Published: January 2022

AbstractBackground:Obesity increases the risk of post-operative arrhythmias in adults undergoing cardiac surgery, but little is known regarding the impact of obesity on post-operative arrhythmias after CHD surgery.Methods:Patients undergoing CHD surgery from 2007 to 2019 were prospectively enrolled in the parent study. Telemetry was assessed daily, with documentation of all arrhythmias. Patients aged 2–20 years were categorised by body mass index percentile for age and sex (underweight <5, normal 5–85, overweight 85–95, and obese >95). Patients aged >20 years were categorised using absolute body mass index. We investigated the impact of body mass index category on arrhythmias using univariate and multivariate analysis.Results:There were 1250 operative cases: 12% underweight, 65% normal weight, 12% overweight, and 11% obese. Post-operative arrhythmias were observed in 38%. Body mass index was significantly higher in those with arrhythmias (18.8 versus 17.8, p = 0.003). There was a linear relationship between body mass index category and incidence of arrhythmias: underweight 33%, normal 38%, overweight 42%, and obese 45% (p = 0.017 for trend). In multivariate analysis, body mass index category was independently associated with post-operative arrhythmias (p = 0.021), with odds ratio 1.64 in obese patients as compared to normal-weight patients (p = 0.036). In addition, aortic cross-clamp time (OR 1.007, p = 0.002) and maximal vasoactive–inotropic score in the first 48 hours (OR 1.03, p = 0.04) were associated with post-operative arrhythmias.Conclusion:Body mass index is independently associated with incidence of post-operative arrhythmias in children after CHD surgery.
The role and efficacy of routine high-sensitivity troponin T screening in paediatric COVID-19
Authors: Ramoğlu Mehmet G. , Karagözlü Selen , Bayram Özlem , Bakhtiyarzada Jeyhun , Aydın Alperen , Vatansever Göksel , Özdemir Halil , Tekin Deniz , Uçar Tayfun , Çiftçi Ergin , Tutar Ercan 
Published: January 2022

AbstractObjective:We aimed to evaluate the efficacy and role of high-sensitivity troponin T in children with a confirmed SARS-CoV-2 infection and also the correlation of troponin T levels with symptoms, and echocardiographic findings were analysed.Methods:Two hundred and fourteen patients with a confirmed SARS-CoV-2 infection between the dates of 28 March and 15 August 2020 were enrolled in this retrospective single-centre study. Patients with comorbidities and diagnosed as multisystem inflammatory syndrome in children were excluded. Demographic data, clinical and laboratory parameters were evaluated. The patients were classified and compared according to the troponin positivity. The correlation of troponin T with symptoms and echocardiographic findings was analysed.Results:The most common symptoms in the whole study group were fever (53.3%) and cough (24.8%). Troponin T levels were elevated in 15 (7%) patients. The most common symptom in patients with troponin positivity was also fever (73.3%). Troponin T positivity was significantly higher in patients under the age of 12 months and troponin T levels were negatively correlated with age. C-reactive protein levels were elevated in 77 (36%) of the patients in the whole group and 7 (46.7%) of 15 patients with troponin positivity. C-reactive protein levels were similar between groups.Conclusion:Routine troponin screening does not yield much information in previously healthy paediatric COVID-19 patients without any sign of myocardial dysfunction. Elevated troponin levels may be observed but it is mostly a sign of myocardial injury without detectable myocardial dysfunction in this group of patients.
A systematic review of the evidence supporting post-operative antithrombotic use following cardiopulmonary bypass in children with CHD
Authors: Thompson Elizabeth J. , Foote Henry P. , Li Jennifer S. , Rotta Alexandre T. , Goldenberg Neil A. , Hornik Christoph P. 
Published: January 2022

AbstractObjectives:To determine the optimal antithrombotic agent choice, timing of initiation, dosing and duration of therapy for paediatric patients undergoing cardiac surgery with cardiopulmonary bypass.Methods:We used PubMed and EMBASE to systematically review the existing literature of clinical trials involving antithrombotics following cardiac surgery from 2000 to 2020 in children 0–18 years. Studies were assessed by two reviewers to ensure they met eligibility criteria.Results:We identified 10 studies in 1929 children across three medications classes: vitamin K antagonists, cyclooxygenase inhibitors and indirect thrombin inhibitors. Four studies were retrospective, five were prospective observational cohorts (one of which used historical controls) and one was a prospective, randomised, placebo-controlled, double-blind trial. All included were single-centre studies. Eight studies used surrogate biomarkers and two used clinical endpoints as the primary endpoint. There was substantive variability in response to antithrombotics in the immediate post-operative period. Studies of warfarin and aspirin showed that laboratory monitoring levels were frequently out of therapeutic range (variably defined), and findings were mixed on the association of these derangements with bleeding or thrombotic events. Heparin was found to be safe at low doses, but breakthrough thromboembolic events were common.Conclusion:There are few paediatric prospective randomised clinical trials evaluating antithrombotic therapeutics post-cardiac surgery; most studies have been observational and seldom employed clinical endpoints. Standardised, validated endpoints and pragmatic trial designs may allow investigators to determine the optimal drug, timing of initiation, dosing and duration to improve outcomes by limiting post-operative morbidity and mortality related to bleeding or thrombotic events.
The Company Prosodic Deficits Keep Following Right Hemisphere Stroke: A Systematic Review
Authors: Sheppard Shannon M. , Stockbridge Melissa D. , Keator Lynsey M. , Murray Laura L. , Blake Margaret Lehman ,   Right Hemisphere Damage working group, Evidence-Based Clinical Research Committee, Academy of Neurologic Communication Disorders and Sciences
Published: January 2022

AbstractObjectives:The aim of this systematic review was to identify the presence and nature of relationships between specific forms of aprosodia (i.e., expressive and receptive emotional and linguistic prosodic deficits) and other cognitive-communication deficits and disorders in individuals with right hemisphere damage (RHD) due to stroke.Methods:One hundred and ninety articles from 1970 to February 2020 investigating receptive and expressive prosody in patients with relatively focal right hemisphere brain damage were identified via database searches.Results:Fourteen articles were identified that met inclusion criteria, passed quality reviews, and included sufficient information about prosody and potential co-occurring deficits. Twelve articles investigated receptive emotional aprosodia, and two articles investigated receptive linguistic aprosodia. Across the included studies, receptive emotional prosody was not systematically associated with hemispatial neglect, but did co-occur with deficits in emotional facial recognition, interpersonal interactions, or emotional semantics. Receptive linguistic processing was reported to co-occur with amusia and hemispatial neglect. No studies were found that investigated the co-occurrence of expressive emotional or linguistic prosodic deficits with other cognitive-communication impairments.Conclusions:This systematic review revealed significant gaps in the research literature regarding the co-occurrence of common right hemisphere disorders with prosodic deficits. More rigorous empirical inquiry is required to identify specific patient profiles based on clusters of deficits associated with right hemisphere stroke. Future research may determine whether the co-occurrences identified are due to shared cognitive-linguistic processes, and may inform the development of evidence-based assessment and treatment recommendations for individuals with cognitive-communication deficits subsequent to RHD.
Primary non-Hodgkin’s lymphoma of the orbit: treatment outcomes from India
Authors: Yadav Budhi Singh , Simha Vjai 
Published: January 2022

Abstract

Background:
Primary non-Hodgkin’s lymphoma (NHL) of the orbit is rare. Orbital NHLs show good response to both radiotherapy (RT) and chemotherapy, and hence, the emphasis should be to ensure maximum cure rate with minimum morbidity. In this study, we present the clinical profile and treatment outcomes of patients with NHL who had initial presentation in the orbit.

Materials and methods:
In this retrospective analysis, case records of patients with a diagnosis of NHL of the orbit were analysed from January 2005 to January 2015. Patients were worked up and staged according to the Ann Arbor system. Patients with large tumours were initially given chemotherapy with CHOP regimen (cyclophosphamide, vincristine, adriamycin and prednisolone) three weekly for 4–6 cycles. Patients with residual disease were given RT 20–30 Gy at 2 Gy per fraction. RT when given as a primary treatment consisted of 36–45 Gy at 1·8–2 Gy per fraction on either Cobalt 60 machine or linear accelerator.

Results:
A total of 52 patients with diagnosis of orbital NHL were included in this study. Median age at presentation was 57 years (range 13–71). Left, right and bilateral orbit was involved in 21 (40%), 28(54%) and 3(6%) patients, respectively. Low- and high-grade pathology was seen in 39(75%) and 13(25%) patients, respectively. On immunohistochemistry, 23(44%) tumors were CD 20 positive. After staging, 33 (63%) patients had stage I disease. Median tumour size was 4·0 × 3·2 × 1·5 cm (1·7 × 1·7 × 1·4 cm to 5·8 × 4·0 × 4·7 cm). Primary RT was given to 7(13%) patients. Upfront chemotherapy was given in 45(86·5%) patients, out of which 24 had stage I disease. RT consolidation was done in 26 (50%) patients for residual disease after chemotherapy. Median follow-up was 88 months (range 29–183 months). Relapse occurred in 6(9·6%) patients; 2 local; 2 local + distant and in 2 distant alone. These patients were successfully salvaged with systemic chemotherapy and local RT. One patient died due to neutropenia. Overall survival in this series was 96%.

Conclusions:
Excellent local control was achieved with initial chemotherapy followed by RT for primary orbital NHL with minimal toxicity. We recommend a dose of 36–40 Gy for definitive RT and 30 Gy for lymphoma following chemotherapy using 2 Gy/fraction for Indian patients who present with bulky tumours. RT should be incorporated in treatment of orbital NHL whenever possible as it is safe, effective and is associated with minimal complications.
Which Picker Fits My Data? A Quantitative Evaluation of Deep Learning Based Seismic Pickers
Authors: Münchmeyer Jannes , Woollam Jack , Rietbrock Andreas , Tilmann Frederik , Lange Dietrich , Bornstein Thomas , Diehl Tobias , Giunchi Carlo , Haslinger Florian , Jozinović Dario , Michelini Alberto , Saul Joachim , Soto Hugo 
Published: January 2022

AbstractSeismic event detection and phase picking are the base of many seismological workflows. In recent years, several publications demonstrated that deep learning approaches significantly outperform classical approaches, achieving human‐like performance under certain circumstances. However, as studies differ in the datasets and evaluation tasks, it is unclear how the different approaches compare to each other. Furthermore, there are no systematic studies about model performance in cross‐domain scenarios, that is, when applied to data with different characteristics. Here, we address these questions by conducting a large‐scale benchmark. We compare six previously published deep learning models on eight data sets covering local to teleseismic distances and on three tasks: event detection, phase identification and onset time picking. Furthermore, we compare the results to a classical Baer‐Kradolfer picker. Overall, we observe the best performance for PhaseNet, closely followed by EQTransformer and GPD. Furthermore, we conduct a cross‐domain study, analyzing model performance on data sets they were not trained on. We show that trained models can be transferred between regions with only mild performance degradation, but models trained on regional data do not transfer well to teleseismic data. As deep learning for detection and picking is a rapidly evolving field, we ensured extensibility of our benchmark by building our code on standardized frameworks and making it openly accessible. This allows model developers to easily evaluate new models or performance on new data sets. Furthermore, we make all trained models available through the SeisBench framework, giving end‐users an easy way to apply these models.
Changes in Arctic Stratification and Mixed Layer Depth Cycle: A Modeling Analysis
Authors: Hordoir Robinson , Skagseth Øystein , Ingvaldsen Randi B. , Sandø Anne Britt , Löptien Ulrike , Dietze Heiner , Gierisch Andrea M. U. , Assmann Karen M. , Lundesgaard Øyvind , Lind Sigrid 
Published: January 2022

AbstractClimate change is especially strong in the region of the Arctic Ocean, and will have an important impact on its thermo‐haline structure. We analyze the results of a hindcast simulation of a new 3D ocean model of the Arctic and North Atlantic oceans for the period 1970–2019. We compared the time period 1970–1999 with the time period 2010–2019. The comparison showed that there is a decrease of stratification between the two periods over most of the shallow Arctic shelf seas and in the core of the Transpolar Ice Drift. Fresh water inputs to the ocean surface decline, and inputs of momentum to the ocean increase, which can explain the decrease in stratification. The comparison also showed that the mixed layer becomes deeper during winter, in response to the weakened stratification owing to increased vertical mixing. The comparison of summer mixed layer depths between the two time periods follows a deepening pattern that is less evident. Regional exceptions include the Nansen Basin and the part of the Canadian Basin bordering the Canadian Archipelago, where the mixed layer shoals. Trends of freshwater fluxes imply that the changes of haline stratification in these regions are also influenced by other processes, for example, horizontal advection of fresh water, increased mixing and changes in the underlaying water masses. Runoff increase toward the Arctic Ocean can locally decrease but also increase salinity, and has an impact on stratification which can be explained by coastal dynamics. The results emphasize the non‐linear nature of Arctic Ocean dynamics.
Boundary Layer Characteristics Over Complex Terrain in Central Taiwan: Observations and Numerical Modeling
Authors: Cheng Fang‐Yi , Wang Yu‐Tzu , Huang Mu‐Qun , Lin Pay‐Liam , Lin Ching‐Ho , Lin Po‐Hsiung , Wang Sheng‐Hsiang , Tsuang Ben‐Jei 
Published: January 2022

AbstractThe development of the atmospheric boundary layer and flow circulation becomes complicated over complex terrain. A field campaign involving the acquisition of tethersonde, ozonesonde and 10‐m meteorological tower observations was conducted during September 2–8, 2013, over the Puli Basin located in the mountainous area of central Taiwan to investigate the evolution of the planetary boundary layer (PBL) and flow circulation. In addition, numerical simulations using the Weather Research and Forecasting (WRF) model were performed to examine the three‐dimensional air flow variations. Analysis of the tethersonde data indicated a well‐mixed boundary layer structure and a steady westerly flow over the Puli Basin during the daytime that became further enhanced in the afternoon. The 600‐m resolution WRF model simulation showed that the enhanced wind flow in the afternoon was due to the inland penetration of the onshore sea breeze, which also transported high concentrations of O3 from the western metropolitan area into the basin. During the nighttime, a stable boundary layer formed, above which a nocturnal low‐level jet formed throughout the campaign period in the Puli Basin. The WRF model is able to reproduce the general variations in the wind flows and thermal structures. Furthermore, the diagnostic PBL height estimated based on the critical Richardson number provides an enhanced understanding of the evolutionary characteristics of the PBL over complex terrain.
TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas
Authors: Li Jiabo , Wang Xuya , Chen Lulu , Zhang Jinhao , Zhang Yiming , Ren Xiao , Sun Jinzhang , Fan Xiaoguang , Fan Jikang , Li Tao , Tong Luqing , Yi Li , Chen Lei , Liu Jie , Shang Guanjie , Ren Xiude , Zhang Hao , Yu Shengping , Ming Haolang , Huang Qiang , Dong Jun , Zhang Chen , Yang Xuejun 
Published: January 2022

AbstractGlioblastoma is the most common primary intracranial malignant tumor in adults and has high morbidity and high mortality. TMEM158 has been reported to promote the progression of solid tumors. However, its potential role in glioma is still unclear. Here, we found that TMEM158 expression in human glioma cells in the tumor core was significantly higher than that in noncancerous cells at the tumor edge using bioinformatics analysis. Cancer cells in patients with primary GBMs harbored significantly higher expression of TMEM158 than those in patients with WHO grade II or III gliomas. Interestingly, regardless of tumor grading, human glioma samples that were IDH1-wild-type (IDH1-WT) exhibited higher expression of TMEM158 than those with IDH1-mutant (IDH1-Mut). We also illustrated that TMEM158 mRNA expression was correlated with poor overall survival in glioma patients. Furthermore, we demonstrated that silencing TMEM158 inhibited the proliferation of glioma cells and that TMEM158 overexpression promoted the migration and invasion of glioma cells by stimulating the EMT process. We found that the underlying mechanism involves STAT3 activation mediating TMEM158-driven glioma progression. In vivo results further confirmed the inhibitory effect of the TMEM158 downregulation on glioma growth. Collectively, these findings further our understanding of the oncogenic function of TMEM158 in gliomas, which represents a potential therapeutic target, especially for GBMs.
Optical coherence tomography angiography for the detection of macular neovascularization—comparison of en face versus cross-sectional view
Authors: Siggel Robert , Spital Christel , Lentzsch Anna , Liakopoulos Sandra 
Published: January 2022

AbstractPurposeTo evaluate sensitivity and specificity of swept source-optical coherence tomography angiography (SS-OCTA) en face images versus cross-sectional OCTA versus a combination of both for the detection of macular neovascularization (MNV).DesignProspective cohort study.ParticipantsConsecutive patients with various chorioretinal diseases and subretinal hyperreflective material (SHRM) and/or pigment epithelial detachment (PED) on OCT possibly corresponding to MNV in at least one eye.Methods102 eyes of 63 patients with fluorescein angiography (FA), OCT and SS-OCTA performed on the same day were included. FA images, the outer retina to choriocapillaris (ORCC) OCTA en face slab, a manually modified en face slab (‘custom slab’), cross-sectional OCTA and a combination of OCTA en face and cross-section were evaluated for presence of MNV.Main outcome measuresSensitivity and specificity for MNV detection, as well as the concordance was calculated using FA as the reference.ResultsOCTA en face imaging alone yielded a sensitivity of 46.3% (automated)/78.1% (custom) and specificity of 93.4% (automated)/88.5% (custom) for MNV detection. Cross-sectional OCTA (combination with en face) resulted in a sensitivity of 85.4% (82.9%) and specificity of 82.0% (85.3%). Concordance to FA wasmoderatefor automated en face OCTA (κ = 0.43), andsubstantialfor custom en face OCTA (κ = 0.67), cross-sectional OCTA (κ = 0.66) and the combination (κ = 0.68).ConclusionSegmentation errors result in decreased sensitivity for MNV detection on automatically generated OCTA en face images. Cross-sectional OCTA allows detection of MNV without manual modification of segmentation lines and should be used for evaluation of MNV on OCTA.
Unconventional metabolites in chromatin regulation
Authors: Gapa Liubov , Alfardus Huda , Fischle Wolfgang 
Published: January 2022

Abstract
Chromatin, the complex of DNA and histone proteins, serves as a main integrator of cellular signals. Increasing evidence links cellular functional to chromatin state. Indeed, different metabolites are emerging as modulators of chromatin function and structure. Alterations in chromatin state are decisive for regulating all aspects of genome function and ultimately have the potential to produce phenotypic changes. Several metabolites such as acetyl-CoA, S-adenosylmethionine (SAM) or adenosine triphosphate (ATP) have now been well characterized as main substrates or cofactors of chromatin-modifying enzymes. However, there are other metabolites that can directly interact with chromatin influencing its state or that modulate the properties of chromatin regulatory factors. Also, there is a growing list of atypical enzymatic and nonenzymatic chromatin modifications that originate from different cellular pathways that have not been in the limelight of chromatin research. Here, we summarize different properties and functions of uncommon regulatory molecules originating from intermediate metabolism of lipids, carbohydrates and amino acids. Based on the various modes of action on chromatin and the plethora of putative, so far not described chromatin-regulating metabolites, we propose that there are more links between cellular functional state and chromatin regulation to be discovered. We hypothesize that these connections could provide interesting starting points for interfering with cellular epigenetic states at a molecular level.