bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fähigkeitsmodell für die Sensor-/ Aktor-Rekonfiguration
Authors: Hong Xuan-Luu , Fay Alexander , Backhaus Sascha , Küstner David , Koch Philip , Pfrommer Julius , Bense Rolf 
Published: January 2022

Produzierende Unternehmen müssen ihre Produktionsprozesse immer häufiger an wechselnde Anforderungen, die sich aus zunehmend individuelleren Aufträgen ergeben, anpassen. Für eine effiziente Produktionsplanung und Arbeitsvorbereitung soll die Überprüfung, welche Produkte mit welchen vorhandenen Ressourcen hergestellt werden können, assistiert beziehungsweise teilweise automatisiert werden. Besonderes Augenmerk liegt dabei auf rekonfigurierbaren Ressourcen. Mit Hilfe von computerauswertbaren Fähigkeitsmodellen von Produktionsressourcen kann die Herstellbarkeit schneller geprüft werden. Darüber hinaus können diese Modelle verwendet werden, um Konfigurationen zu generieren, die den geänderten Anforderungen entsprechen. Dieser Beitrag stellt einen Schnittstellen-orientierten Ansatz für die Fähigkeitsmodellierung von Produktionsressourcen vor. Des Weiteren wird die Implementierung des Ansatzes in AutomationML vorgestellt. Die Anwendbarkeit des Ansatzes wird anhandeines automatisierten Nietsystems bei Airbus veranschaulicht.
RESILIÊNCIA, PERCEPÇÃO TEMPORAL E AUTOEFICÁCIA: UM ESTUDO SOBRE AS DIFERENTES GERAÇÕES DE TRABALHADORES
Authors: Nunes Lereno da Costa , Gabriel Soares Leony Alexandre 
Published: January 2022

Esta pesquisa objetivou investigar qual linha de pesquisa (conflito geracional ou adaptação geracional) é válida para uma seleção de trabalhadores formais de organizações públicas e/ou privadas, com acesso às redes sociais e a meios eletrônicos de comunicação. Neste estudo foi realizada uma regressão via Mínimos Quadrados Ordinários (MQO), com erros robustos. Verificou-se como os cinco fatores de percepção temporal (policronicidade, velocidade, pontualidade, profundidade temporal e arrastamento nas modalidades sincronia, liderança e condução) influenciam a impressão de autoeficácia de forma diferente a grupos de gerações de trabalhadores (Baby Boomers, X, Y e Z) em meio ao incremento da rapidez, da tecnologia e racionalização do tempo nas organizações. Os resultados indicaram que três fatores de percepção temporal (Policronia, Velocidade e Arrastamento), associados à impressão de autoeficácia, não apresentaram diferenças estatisticamente significante para trabalhadores formais pertencentes a diferentes gerações. A conclusão principal é que as gerações estão se adaptando às exigências tecnológicas impostas pelas organizações em busca da produtividade. Como contribuição teórica esta pesquisa apresenta uma linha de construção acadêmica pouco utilizada, quando constrói a ideia que as gerações, embora a literatura exponha as suas diferenças constatadas em resquícios pontuais de conflitos, tendam a adaptar-se às exigências do mercado de trabalho, construindo um novo perfil laboral. Tal ideia poderá fomentar novos estudos comparativos entre as gerações de trabalhadores atuantes no mercado de trabalho. ====================================DOI: 10.18226/23190639.v9n2.04 Lereno da Costa Nunes*, Fucape Business School, Brasil. E-mail:lereno@ifma.edu.br Leony Alexandre Gabriel Soares, Fucape Business School, Brasil. E[1]mail: leony_alexandre@hotmail.com Submetido: Abril 2020Aceito: Fevereiro 2021 *Contato para Correspondência
History of the Russian Far East. Introduction
Authors: Kradin Nikolay 
Published: January 2022

The Russian Far East occupies approximately 36 % of the country&apos;s territory. But only 5,6 % of the population lives here. This introduction summarizes general ideas of this special issue. It tells about the main stages and the most important events in the history of the Russian Far East from the Stone Age to the present day. These processes are considered on the general background of world history.
PHATIC COMMUNION AS A UNIFIER AS PORTRAYED IN ‘WONDER’
Authors: Mawadda Sakinah 
Published: January 2022

<p><span>Phatic communication or so called ‘phatic communion’ is said to be a kind of language used to create, to maintain and to strengthen the social bond between individuals. However, the concept of phatic communication in which it requires neither an exchange of information nor a specific purpose in its use raises the question regarding the necessity and the effectiveness of phatic communication. Responding to this issue, this study is conducted to show the significance of phatic communication in colloquial speech event. This study aims to prove the role of phatic communication as a unifier between individuals as portrayed in Wonder movie reflected in the life of a boy with Treacher Collins syndrome, Auggie. Considering the hardships he encounters in his social life, this study aims to see how phatic communication acts as a unifier for Auggie by scrutinizing the types and the functions of phatic communication in his social life. The analysis suggests that 1) the types of expressions serving as phatic communication in Wonder are divided into greeting, making small talk, agreeing on something and joking, and 2) the functions of the phatic expressions are to express solidarity and friendship and to create harmony and comfort.</span></p><p><strong><em>Keywords: </em></strong>Phatic Communication, Phatic Communion, Unifier</p><p><span><br /></span></p>
Acute Carpal Tunnel Syndrome After Radial Artery Cannulation
Authors: Garríguez-Pérez Daniel , Serrano-Mateo Laura , Donadeu-Sánchez Susana , Gimeno María Dolores , Marco Fernando 
Published: January 2022

Case:
A 20-year-old postpartum woman developed paresthesias and intolerable pain over the volar aspect of the first through fourth fingers, after radial artery cannulation (RAC) during cesarean section. Ultrasonography did not show any hematoma in the forearm. Urgent carpal tunnel release and median nerve decompression were performed, resulting in complete disappearance of symptoms.

Conclusion:
Acute median nerve compression is a rare injury in its own, but it is even rarer as a complication of RAC. Urgent decompression should be performed as soon as possible to avoid future neurological deficits.
Rapidly Progressive Paraplegia Resulting from Latent Cervical Dural Arteriovenous Fistula After Lumbar Surgery
Authors: Han Zhenchuan , Ren Bowen , Liu Yang , Liu Jianheng , Wang Zheng , Mao Keya 
Published: January 2022

Case:
A 68-year-old woman developed symptoms of acute paraplegia due to an occult cervical dural arteriovenous fistula (DAVF) after a minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). She was subsequently diagnosed by angiography and treated with vascular embolization. A 2-year follow-up showed that the patient's upper limb muscle strength returned to normal, and the lower limb muscle strength partially improved with remnant motor dysfunction.

Conclusion:
For patients with symptoms of nerve injury inconsistent with the spinal surgery site, a possibility of DAVF should be considered, and related investigations should be performed. Once diagnosed, active treatment is required.
Severe Hip Dysplasia in Wiedemann-Steiner Syndrome Treated with Bilateral Bernese Periacetabular Osteotomy
Authors: Evans David C. , Novais Eduardo N. 
Published: January 2022

Case:
Wiedemann-Steiner syndrome (WDSTS) is a rare autosomal dominant disorder with many phenotypic characteristics, including multiple orthopaedic manifestations. Of these, symptomatic significant hip dysplasia has been variably noted. Nonetheless, few reports detail surgical treatment for these patients, including hip preservation for those with hip dysplasia.

Conclusion:
Periacetabular osteotomy allows for the correction of severe hip dysplasia in patients with WDSTS. With proper recognition and timely intervention, adequate care may be provided for these patients.
Can Areas of High Alkalinity Freshwater Discharge Provide Potential Refugia for Marine Calcifying Organisms?
Authors: Amergian Kyle E. , Beckwith Sean , Gfatter Christian , Selden Corday , Hallock Pamela 
Published: January 2022

ABSTRACTThe Springs Coast of Florida, USA (northeast Gulf of Mexico), includes an extensive system of springs and spring-fed streams that discharge billions of liters of water daily. The spring waters have high alkalinity and high calcium concentrations due to the Paleogene limestone lithology of this region. Benthic foraminifers are abundant on the shallow shelf, including Archaias angulatus which hosts chlorophyte symbionts. This study was motivated by the hypothesis that areas of discharge from limestone lithofacies may provide refugia for calcifying organisms during ocean acidification. Environmental data and sediment samples were available from 41 sites at depths &lt;8 m. Benthic foraminiferal species identified (142) included 65 porcelaneous, 65 hyaline, and 12 agglutinated taxa, with 13 species sufficiently common to make up ≥2% total relative abundance. Overall, 58% of the specimens were porcelaneous and most of the remainder were hyaline. Smaller miliolids dominated in samples from most of the inshore polyhaline sites (22–30), while hyaline taxa co-dominated the more offshore sites (salinities &gt;30), representing a distribution reversal compared to previous reports from Gulf of Mexico coastal habitats. The elevated alkalinity and calcium ion concentrations associated with freshwater discharge from limestone lithofacies allows Ar. angulatus and small miliolids to thrive in polyhaline waters.
Warming and redistribution of N inputs drive long-term increase in terrestrial N2O emission factor
Authors: Harris Eliza , Yu Longfei , Wang Yingping , Mohn Joachim , Henne Stephan , Bai Edith , Barthel Matti , Bauters Marijn , Boeckx Pascal , Dorich Chris , Farrell Mark , Krummel Paul , Loh Zoe , Reichstein Markus , Six Johan , Steinbacher Martin , Wells Naomi , Bahn Michael , Rayner Peter 
Published: January 2022

Abstract
Anthropogenic nitrogen inputs cause major negative environmental impacts, including emissions of the important greenhouse gas N2O. Despite their importance, changes in terrestrial N loss pathways driven by global change and spatial redistribution of N inputs are highly uncertain. We present a novel coupled soil-atmosphere isotope model (IsoTONE) to quantify terrestrial N losses and N2O emission factors from 1850-2020, initialised using a global dataset of natural soil δ15N, and optimized with a tropospheric timeseries of N2O isotopic composition using a Bayesian framework.

N inputs from atmospheric deposition caused the majority (51%) of anthropogenic N2O emissions from soils in 2020. Long-term growth in emissions was driven by fertilization and deposition, however biological fixation caused subdecadal variability in emissions. N2O emission factors (EF) show large spatial variability due to climate and soil parameters. The mean effective global EF for N2O (weighted by N inputs) was 4.3±0.3% in 2020, much higher than the land surface area-weighted mean (1.1±0.1%). Climate change and redistribution of fertilisation have driven an increase in global EF over the past century, which accounts for 18% of the anthropogenic soil flux in 2020. Predicted increases in fertilisation in emerging economies will accelerate N2O-driven climate warming in coming decades, unless targeted mitigation measures focussing on fertiliser management and reduced N deposition are introduced.
New Class of Broad-Spectrum Antivirals Improves Influenza Virus Vaccine Development
Authors: Pacheco Armando` , Buchholz David , Monreal Isaac , Xu Shi , Imbiakha Brian , Sahler Julie , Jager Mason , Lai Alex , Contreras Erik , Cook Brandan , Ralalage Elshan , Liu Qian , Yeo Yao Yu , Ma Andrew , Zamora Juana , Shil Niraj , Jones-Burrage Sara , Pritchard Suzanne , Yang Chuntao , Zhao Yu , Mohamed Zeinab , Xu Cheyan , Daniel Susan , Jung Michael , de Walle Gerlinde Van , Mukhopadhyay Suchetana , Shimamura Masako , Goodman Alan , Hardy Michele , Bose Santanu , Nicola Anthony , Freed Jack , August Avery , Jones Jace , Xian Ming , Aguilar Hector 
Published: January 2022

Abstract
Enveloped viruses can cause devastating zoonotic diseases and are the most likely to cause global pandemics. We identified a new class of small-molecule sulfur-containing antiviral compounds (XM series) that broadly inhibit enveloped viruses. The antivirals’ mechanism of action was explored via various multidisciplinary approaches, concluding that the XM antivirals alter membrane lipid chemical compositions, increase membrane order deep within the hydrophobic region of the bilayer, and increase membrane phase transition temperatures. Such effects cause inhibition of membrane fusion and viral entry, while leaving the viral glycoproteins and genomes largely unaffected. Consequently, we tested whether these features would lead to effective whole inactivated enveloped virus vaccines. As a proof-of-principle, we generated an inactivated influenza virus (IIV) vaccine using compound XM-01 (XM-01-IIV). We compared this new vaccine to traditional paraformaldehyde-inactivated, to control compound-inactivated, and to live virus vaccines, using a mouse model of disease. Excitingly, compared to a traditional IIV vaccine, XM-01-IIV vaccination improved neutralizing antibody responses against both hemagglutinin and neuraminidase, and decreased mouse morbidity and mortality following influenza virus challenge. Therefore, this study uncovers a novel class of broadly acting antivirals that enhances influenza virus vaccine development and offers great potential for broadly generating future highly-potent inactivated enveloped virus vaccines.
Mechanical Characterization of Nanocelluloses/Cellulose Acetate Composite Nanofibrous Membranes
Authors: Attari Nasrin , Hausler Robert 
Published: January 2022

Abstract
Extensive research on membrane technologies stems from the necessity for drinking water purification, wastewater treatment, and recycling polluted water by filtration. For the successful commercialization of a filtration process, the improvement of the mechanical properties of membrane systems is an essential factor. Pressure-driven membrane filtration processes require sufficient mechanical strength to withstand operational conditions.

In this study, cellulose acetate composite nanofibrous membranes, including nanocelluloses as reinforcing additives, were synthesized by the electrospinning technique. The polymer solutions were prepared from different weight percentages of Cellulose nanocrystals (CNCs) and 2,2,6,6-tetramethyl-1-piperidinyloxyl- (TEMPO) oxidized Cellulose nanofibrils (TOCNFs) from 0 to 1 wt.\% and 15 wt\% of Cellulose Acetate (CA). The impacts of heat post treatment process on the mechanical properties of composite electrospun nanofibrous membranes (ENMs) has been studied. The chemical and physical properties of the composite ENMs were investigated. The morphological structure of ultimate composite ENMs was studied by scanning electron microscopy (SEM), and the chemical interactions were demonstrated by Fourier transform infrared spectroscopy. A tensile test was performed to evaluate the mechanical properties of the composite ENMs. The highest tensile strength was achieved for heat-treated 0.25TOCNF/CA composite nanofibrous membrane. These results verify that modifying morphology and improving mechanical strength expand the application of electrospun nanofibrous membranes in water purification processes.
Development and Validation of a Prediction Model of Perioperative Hypoglycemia Risk in Patients with Type 2 Diabetes Undergoing Elective Surgery
Authors: Han Huiwu , Lai Juan , Yan Cheng , Li Xing , Hu Shuoting , He Yan , Li Hong 
Published: January 2022

Abstract
Aim To develop and validate a prediction model to evaluate the perioperative hypoglycemia risk in hospitalized type 2 diabetes mellitus (T2DM) patients undergoing elective surgery. Methods We retrospectively analyzed the electronic medical records of 1410 T2DM patients who had been hospitalized and undergone elective surgery. Regression analysis was used to develop a predictive model for perioperative hypoglycemia risk. The receiver operating characteristic (ROC) curve and the Hosmer-Lemeshow test were used to verify the model.Results Our study showed an incidence of 10.7% for level 1 hypoglycemia and 1.8% for level 2 severe hypoglycemia during the perioperative period. A perioperative hypoglycemic risk prediction model was developed that was mainly composed of four predictors: duration of diabetes≥10year, body mass index (BMI)<18.5kg/m2, coefficient of variation (CV)≥3.0%, and preoperative hypoglycemic regimen of insulin subcutaneous. Based on this model, patients were categorized into three groups: low, medium, and high risk. Internal validation of the prediction model showed high discrimination (ROC statistic = 0.715) and good calibration (no significant differences between predicted and observed risk: Pearson χ2 goodness-of-fit P = 0.765). Conclusions The perioperative hypoglycemic risk prediction model categorizes the risk of hypoglycemia using only 4 predictors and shows good reliability and validity. The model serves as a favorable tool for clinicians to predict hypoglycemic risk and guide future interventions to reduce hypoglycemia risk.
Comparison of Physicochemical Quality, Macronutrient and Energetic Values of Fresh and Canned Tuna After Storage Different Periods
Authors: Baesi Ferideh , Aberoumand Ali 
Published: January 2022

Abstract
We evaluated the nutritional value of fresh and canned tuna based on the date of production and expiration and measured the concentration of heavy metals in samples. The twenty cans of tuna and 5 kg of fresh tuna were prepared. After 6, 9 and 11 months storage of canned fish, percentage of proximate, pH and concentration of heavy metals measured. The results showed that the proximate composition of canned samples changed comparing to the fresh samples during different periods. The percentage of fat and protein increased and decreased significantly respectively. The energy values of canned fish decreased over time, but on 11th month storage after production, it was higher than fresh fish. The concentration of heavy metals significantly increased over time, but ​​obtained contents were lower than the limits allowed by international standards which will not pose a problem for human consumption.
Integrated cell-free DNA and cytokine analysis uncovers distinct tissue injury and immune response patterns in solid organ transplant recipients with COVID-19
Authors: Andargie Temesgen , Zhou Weiqiang , Karaba Andrew , Li Taibo , Seifuddin Fayaz , Rittenhouse Alex , Kong Hyesik , Singh Komudi , Woodward Robert , Iacono Aldo , Avery Robin , Pirooznia Mehdi , Jang Moon , Ji Hongkai , Cox Andrea , Agbor-Enoh Sean 
Published: January 2022

Abstract
COVID-19 pathogenesis is associated with an exuberant inflammatory response. However, the tissue injury pattern and immune response in solid-organ transplant recipients (SOTRs) taking immunosuppressive therapy have not been well characterized. Here, we perform both cfDNA and cytokine profiling on plasma samples to map tissue damage, including allograft injury and delineate underlying immunopathology. We identified injuries from multiple-tissue types, including hematopoietic cells, vascular endothelium, hepatocyte, adipocyte, pancreas, kidney, heart, and lung in SOTRs with COVID-19 that correlates with disease severity. SOTRs with COVID-19 have higher plasma levels of cytokines such as IFN-λ1, IFN-γ, IL-15, IL-18 IL-1RA, IL-6, MCP-2, and TNF-α as compared to healthy controls, and the levels of GM-CSF, IL-15, IL-6, IL-8, and IL-10 were associated with disease severity in SOTRs. Strikingly, IFN-λ and IP-10 were markedly increased in SOTRs compared to immunocompetent patients with COVID-19. Correlation analyses showed a strong association between monocyte-derived cfDNA and inflammatory cytokines/chemokines in SOTRs with COVID-19. Moreover, compared to other respiratory viral infections, COVID-19 induced pronounced injury in hematopoitic, vascular endothelial and endocrine tissues. Allograft injury, measured as donor-derived cfDNA was elevated in SOTRs with COVID-19, including allografts distant from the primary site of infection. Allograft injury correlated with inflammatory cytokines and cfDNA from immune cells. Furthermore, longitudinal analysis identified a gradual decrease of cfDNA and inflammatory cytokine levels in patients with a favorable outcome. Our findings highlight distinct tissue injury and cytokine features in SOTRs with COVID-19 that correlate with disease severity.
MFGE8 Improved Brain Functional Connectivity Between CA1 and LEnt By Activating Efferocytosis in Hippocampus of SAE Rats
Authors: Li Haojia , Liao Hongsen , Du Jiayue , Xu Xiaomin , Chen Yuchen , Zhang Zhiyuan , Si Yanna , Bao Hongguang 
Published: January 2022

Abstract
Background: Sepsis-associated encephalopathy (SAE) is one of the most serious complications of sepsis, along with brain function and cognitive behavioral changes. The process of efferocytosis with microglia was restrained in SAE rats’ hippocampus. We have previously shown that milk fat globule EGF factor 8 protein (MFG-E8) evoked efferocytosis in SAE rats’ brain, and alleviated the inflammnation in hippocampus. The present study investigated the the contribution of MFG-E8 to the brain functional connectivity (FC) of hippocampus and lateral entorhinal cortex in SAE rats by resting-state functional MRI scan.Methods: Sixty adult male Sprague Dawley rats were divided randomly into Sham operation group, cecal ligation and puncture (CLP) group, CLP+MFGE8 group, and CLP+MFGE8+Cilengitide group. After cecal ligation and puncture (CLP) surgery, MFGE8 (3.3ug) was injected intracerebroventricularly (i.c.v.) and cilengitide (10 mg/kg) was injected intraperitoneal. The Morris water maze (MWM) and open filed test (OFT) were performed continuously for five days. Rats were detected by T2-MRI and rs-fMRI scan 8 days post-surgery, then brain tissues were taken for western blotting and pathological observation by HE stained. One-way ANOVA with Tukey’s post-test of all pair of columns was employed statistical analyses.Results: MFGE8 improved performance of neurobehavioral tests in MWM test and OFT. Expression of IL-1β and the proteins of MFGE8, Rac1, and LC3 were up regulated in CLP+MFGE8 group. On the contrary, expression of IL-6, Rac1, and LC3 were down regulated in CLP+MFGE8+cilengitide group. MFGE8 significantly decreased the hyperintense region in hippocampus detected by T2-MRI, and increased ALFF value in SAE rats’ bilateral sensory cortex, motor cortex and visual cortex by rs-fMRI. In addition, MFGE8 increased FC of CA1 and LEnt in same side of cerebral hemisphere, and the FC of CA1 and LEnt was consistent with the behavior result in Morris water maze test.Conclusions: MFGE8 activated efferocytosis with microglia and improved brain function and functional connectivity between CA1 and LEnt which were reflected in behavior tests and fMRI.