bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value co-creation and performance within Brazilian innovation environments
Authors: dos Santos Gustavo Piardi Piardi , Schmidt Serje , Gonçalves Manuela Albornoz , Bohnenberger Maria Cristina 
Published: May 2022

Purpose
This study aims to analyse value co-creation in innovative firms within innovation environments (IEs) in the south region of Brazil from a processual and dynamic perspective, including its antecedents, initiatives and its outcomes in the multiple facets of the firms’ performance.

Design/methodology/approach
A qualitative and quantitative multi-method study was carried out with the management and support teams of these IEs, as well as with a sample of 91 companies installed.

Findings
The results helped clarify the value co-creation process in IEs of an emerging economy, suggesting under which conditions and how value co-creation practices are performed and its significant role in specific performance dimensions of companies.

Research limitations/implications
The study contributes to companies and IEs within emerging economies to prioritize practices related to the co-creation of value to enhance their results.

Originality/value
In emerging countries, IEs struggle to apply their scarce resources to the development of hosted firms. Having value co-creation as a concept that presupposes the involvement of the beneficiary and other actors to improve the companies’ value proposition, its practice may constitute a valuable ally in this effort. However, the dynamics of value co-creation in such environments, its antecedents and specific outcomes are still unclear.
Online counselling and therapy
Authors: Prescott Julie 
Published: May 2022

Purpose
In this edition of digital innovations I will briefly discuss online therapy/counselling.

Design/methodology/approach
The online environment can offer a safe space for many individuals to seek support. The virtual world affords many features the offline world does not.

Findings
In this and the next digital innovations feature I want to look at this online support and how people provide, as well as, seek support virtually.

Originality/value
In this edition I will briefly look at online counselling with a focus on young people, who are a client group, research has found, often prefer to access mental health services online.
Biocrusts increase the resistance to warming‐induced increases in topsoil P pools
Authors: García‐Velázquez Laura , Gallardo Antonio , Ochoa Victoria , Gozalo Beatriz , Lázaro Roberto , Maestre Fernando T. 
Published: May 2022

Abstract

Ongoing global warming and alterations in rainfall patterns driven by climate change are known to have large impacts on biogeochemical cycles, particularly on drylands. In addition, the global increase in atmospheric nitrogen (N) deposition can destabilize primary productivity in terrestrial ecosystems, and phosphorus (P) may become the most limiting nutrient in many terrestrial ecosystems. However, the impacts of climate change on soil P pools in drylands remain poorly understood. Furthermore, it is unknown whether biocrusts, a major biotic component of drylands worldwide, modulate such impacts.

Here we used two long‐term (8–10 years) experiments conducted in Central (Aranjuez) and SE (Sorbas) Spain to test how a ~2.5°C warming, a ~30% rainfall reduction and biocrust cover affected topsoil (0–1 cm) P pools (non‐occluded P, organic P, calcium bound P, occluded P and total P).

Warming significantly increased most P pools—except occluded P—in Aranjuez, whereas only augmented non‐occluded P in Sorbas. The rainfall reduction treatment had no effect on the soil P pools at any experimental site. Biocrusts increased most soil P pools and conferred resistance to simulated warming for major P pools at both sites, and to rainfall reduction for non‐occluded and occluded P in Aranjuez.

Synthesis. Our findings provide novel insights on the responses of soil P pools to warming and rainfall reduction, and highlight the importance of biocrusts as modulators of these responses in dryland ecosystems. Our results suggest that the observed negative impacts of warming on dryland biocrust communities will decrease their capacity to buffer changes in topsoil P driven by climate change.
Identification of Pseudomonas asiatica subsp. bavariensis str. JM1 as the first Nε‐carboxy(m)ethyllysine‐degrading soil bacterium
Authors: Mehler Judith , Behringer Kim Ina , Rollins Robert Ethan , Pisarz Friederike , Klingl Andreas , Henle Thomas , Heermann Ralf , Becker Noémie S. , Hellwig Michael , Lassak Jürgen 
Published: May 2022

SummaryThermal food processing leads to the formation of advanced glycation end products (AGE) such as Nε‐carboxymethyllysine (CML). Accordingly, these non‐canonical amino acids are an important part of the human diet. However, CML is only partially decomposed by our gut microbiota and up to 30% are excreted via faeces and, hence, enter the environment. In frame of this study, we isolated a soil bacterium that can grow on CML as well as its higher homologue Nε‐carboxyethyllysine (CEL) as sole source of carbon. Bioinformatic analyses upon whole‐genome sequencing revealed a subspecies of Pseudomonas asiatica, which we named ‘bavariensis’. We performed a metabolite screening of P. asiatica subsp. bavariensis str. JM1 grown either on CML or CEL and identified N‐carboxymethylaminopentanoic acid and N‐carboxyethylaminopentanoic acid respectively. We further detected α‐aminoadipate as intermediate in the metabolism of CML. These reaction products suggest two routes of degradation: While CEL seems to be predominantly processed from the α‐C‐atom, decomposition of CML can also be initiated with cleavage of the carboxymethyl group and under the release of acetate. Thus, our study provides novel insights into the metabolism of two important AGEs and how these are processed by environmental bacteria.
Risk of obstetric anal sphincter injuries at the time of admission for delivery: A clinical prediction model
Authors: Luchristt Douglas , Meekins Ana Rebecca , Zhao Congwen , Grotegut Chad , Siddiqui Nazema Y. , Alhanti Brooke , Jelovsek John Eric 
Published: May 2022

AbstractObjectiveTo develop and validate a model to predict obstetric anal sphincter injuries (OASIS) using only information available at the time of admission for labour.DesignA clinical predictive model using a retrospective cohort.SettingA US health system containing one community and one tertiary hospital.SampleA total of 22 873 pregnancy episodes with in‐hospital delivery at or beyond 21 weeks of gestation.MethodsThirty antepartum risk factors were identified as candidate variables, and a prediction model was built using logistic regression predicting OASIS versus no OASIS. Models were fit using the overall study population and separately using hospital‐specific cohorts. Bootstrapping was used for internal validation and external cross‐validation was performed between the two hospital cohorts.Main outcome measuresModel performance was estimated using the bias‐corrected concordance index (c‐index), calibration plots and decision curves.ResultsFifteen risk factors were retained in the final model. Decreasing parity, previous caesarean birth and cardiovascular disease increased risk of OASIS, whereas tobacco use and black race decreased risk. The final model from the total study population had good discrimination (c‐index 0.77, 95% confidence interval [CI] 0.75–0.78) and was able to accurately predict risks between 0 and 35%, where average risk for OASIS was 3%. The site‐specific model fit using patients only from the tertiary hospital had c‐stat 0.74 (95% CI 0.72–0.77) on community hospital patients, and the community hospital model was 0.77 (95%CI 0.76–0.80) on the tertiary hospital patients.ConclusionsOASIS can be accurately predicted based on variables known at the time of admission for labour. These predictions could be useful for selectively implementing OASIS prevention strategies.
Melatonin‐mediated postharvest quality and antioxidant properties of fresh fruits: A comprehensive meta‐analysis
Authors: Madebo Miilion Paulos , Zheng Yonghua , Jin Peng 
Published: May 2022

AbstractAt postharvest, fruits have a short shelf life. Recently, there has been much literature on the effects of melatonin on the postharvest quality of horticultural crops. However, reports of various findings comprise mixed claims and product‐specific conclusions. Therefore, a meta‐analysis systematically dissects the comprehensive effect on several fruits. In this meta‐analysis, standard mean difference (SMD) was adopted using a random‐effect model. The study used 36 articles and isolated 24 indicator parameters of postharvest quality and antioxidant properties based on the inclusion criteria. As exhibited in the forest plot, melatonin reduced chilling injury, weight loss, respiration rate, and ethylene content (SMD −0.90, 95% CI [−1.14, −0.65]; I2 = 81%; p < .00001). Similarly, the application of melatonin significantly suppressed electrolyte leakage, malondialdehyde (MDA), hydrogen peroxide, superoxide anion, lipoxygenase, and polyphenol oxidase (SMD −0.89, 95% CI [−1.09, −0.69]; I2 = 70%; p < .00001). In addition, exogenous melatonin application induced endogenous melatonin content, phenolic content, and flavonoid and anthocyanin contents (SMD 1.15, 95% CI [0.91, 1.39]; I2 = 71%; p = .01). Moreover, melatonin treatment enhanced antioxidant activities (catalase, superoxide dismutase, peroxidase, ascorbate peroxidase, and phenylalanine ammonia‐lyse) (SMD 1.37, 95% CI [1.03, 1.71]; I2 = 86%; p < .00001). Thus, in the whole study, the overall effect was significantly high in treated fruit (p < .0001), and the overall heterogeneity was above (I2) > 70%. In addition, the funnel plot showed symmetry in the most selected studies. To sum up, the result gives a further understanding of melatonin's capabilities in reducing postharvest losses and maintaining the quality of fresh fruits.
A comparison between endoscopic ultrasound–guided and percutaneous biliary drainage after failed endoscopic retrograde cholangiopancreatography for malignant biliary obstruction: A retrospective cohort study
Authors: Chow Hin San , Chan Justin Chung Yan , Cheung Wai Hung , Lai Amanda Yun Ling , Yu Ellen Lok Man , Lai Tak Wing 
Published: May 2022

AbstractAimEndoscopic ultrasonography–guided biliary drainage (EUS‐BD) is increasingly used as an alternative therapeutic modality to percutaneous transhepatic biliary drainage (PTBD) for malignant biliary obstruction in patients who fail endoscopic retrograde cholangiopancreatography (ERCP). We conducted a retrospective study comparing the success rate and safety of the two drainage methods.Patients and MethodsThere were 121 consecutive patients undergoing EUS‐BD or PTBD who had malignant biliary obstruction that failed to be treated by ERCP at Princess Margaret Hospital between August 2015 and May 2021. Thirty‐five patients with biliary obstruction at or proximal to hilar level were excluded from this study. A retrospective cohort study was performed for 26 patients who underwent EUS‐BD (choledochoduodenostomy or hepaticogastrostomy) and 60 patients who underwent PTBD. Their clinical data and endoscopic data, demographic data, diagnosis, laboratory data, complications, number of re‐interventions, in‐hospital death and length of hospitalisation were extracted and compared.ResultsThe clinical success rates for EUS‐BD and PTBD were 25 out of 26 (96.2%) and 43 out of 60 (71.7%), respectively (P = .01). The technical success rates were 25 out of 26 (96.2%) and 57 out of 60 (95.0%), respectively (P > .99). Among those technically successful cases, complications were significantly fewer in the EUS‐BD group (4%) than in the PTBD group (33.3%). There were significantly fewer re‐interventions, shorter length of hospitalisation and fewer in‐hospital death in the EUS‐BD group. No significant difference in stent/PTBD patency was noted between the two groups.ConclusionEUS‐BD is a safe and effective method of BD in patients with malignant biliary obstruction who failed ERCP. EUS‐BD has a higher rate of clinical success, is associated with fewer complications and has a shorter length of in‐hospital stay compared with PTBD. The overall technical success and stent patency are comparable to PTBD.
Initial experience with a novel biodegradable pancreatic stent in pancreatoduodenectomy
Authors: Yuen Angela Yit Won , Chan Justin Chung Yan , Luk Man Ping , Lee Kit Fai , Lai Tak Wing , Lai Paul B. S. , Ng Kelvin Kwok Chai , Chong Charing Ching Ning 
Published: May 2022

AbstractThe application of biodegradable pancreatic stent in pancreatoduodenectomy has rarely been studied. Archimedes biodegradable stent is a newly designed CE‐approved biodegradable stent. We conducted a retrospective cohort study to evaluate the performance of this stent in patients undergoing pancreatoduodenectomy. Clinical outcomes of these patients were reviewed. Among nine patients in this study, six (66.7%) slow‐degrading, two (22.2%) medium‐degrading, and one (11.1%) fast‐degrading stents were used. Technical success rate was 100%. There was no hospital mortality. Four patients (44.4%) developed clinically relevant post‐operative pancreatic fistula (POPF). Proximal migration of stent occurred in two patients (22%) who were managed conservatively. Five stents (55.5%) degraded within the expected degradation period. In conclusion, the use of Archimedes biodegradable stent in pancreatoduodenectomy is technically feasible. Future study is needed to evaluate its potential efficacy of reducing POPF.
Dnabarcoder: An open‐source software package for analysing and predicting DNA sequence similarity cutoffs for fungal sequence identification
Authors: Vu Duong , Nilsson R. Henrik , Verkley Gerard J. M. 
Published: May 2022

AbstractThe accuracy and precision of fungal molecular identification and classification are challenging, particularly in environmental metabarcoding approaches as these often trade accuracy for efficiency given the large data volumes at hand. In most ecological studies, only a single similarity cutoff value is used for sequence identification. This is not sufficient since the most commonly used DNA markers are known to vary widely in terms of inter‐ and intraspecific variability. We address this problem by presenting a new tool, dnabarcoder, to predict local similarity cutoffs and measure the resolving powers of a biomarker for sequence identification for different clades of fungi. It was shown that the predicted similarity cutoffs varied significantly between the clades of a recently released ITS DNA barcode data set from the CBS culture collection of the Westerdijk Fungal Biodiversity Institute. When classifying a large public fungal ITS data set—the UNITE database—against the barcode data set, the local similarity cutoffs assigned fewer sequences than the traditional cutoffs used in metabarcoding studies. However, the obtained accuracy and precision were significantly improved. Our study showed that it might be better to extract the ITS region from the ITS barcodes to optimize taxonomic assignment accuracy. Furthermore, 15.3, 25.6, and 26.3% of the fungal species of the barcode data set were indistinguishable by full‐length ITS, ITS1, and ITS2, respectively. Except for these indistinguishable species, the resolving powers of full‐length ITS, ITS1, and ITS2 sequences were similar at the species level. Nevertheless, the complete ITS region had a better resolving power at higher taxonomic levels.
Development of transcriptomics‐based growth rate indices in two model eukaryotes and relevance to metatranscriptomics datasets
Authors: Kong Wye‐Lup , Machida Ryuji J. 
Published: May 2022

AbstractGrowth rate estimation is important to understand the flow of energy and nutrient elements in an ecosystem, but it has remained challenging, especially on microscopic organisms. In this study, we propose four growth rate indices that use mRNA abundance ratios between nuclear and mitochondrial genes: (1) total nuclear and mitochondrial mRNA ratio (Nuc:Mito‐TmRNA); (2) nuclear and mitochondrial ribosomal protein mRNA ratio (Nuc:Mito‐RPmRNA); (3) gene ontology (GO) terms and total mitochondrial mRNA ratios; and (4) nuclear and mitochondrial specific gene mRNA ratio. We examine these proposed ratios using RNA‐Seq datasets of Daphnia magna, and Saccharomyces cerevisiae retrieved from the NCBI Short Read Archive. The results showed that both Nuc:Mito‐TmRNA and Nuc:Mito‐RPmRNA ratio indices showed significant correlations with the growth rate for both species. A large number of GO terms mRNA ratios showed significant correlations with the growth rate of S. cerevisiae. Lastly, we identified mRNA ratios of several specific nuclear and mitochondrial gene pairs that showed significant correlations. We foresee future implications for the proposed mRNA ratios used in metatranscriptome analyses to estimate the growth rate of communities and species.
Dividend imputation taxes and the curious case of a price premium between BHP and Billiton American depositary receipts
Authors: Hu Hansi , Walter Terry 
Published: May 2022

AbstractBHP Group was formed in 2001 when the Broken Hill Proprietary Company Limited in Australia merged with the Anglo–Dutch Billiton Plc in the UK to form a dual−listed company. The American Depositary Receipts (ADRs) for BHP and Billiton trade on the NYSE, and despite these two securities having exactly the same voting rights and US dollar denominated dividends, the BHP ADR generally sells at a premium to the Billiton ADR, though that premium has considerable time−series variation. We investigate whether differences in the imputation tax systems that apply to dividends in Australia and the UK help explain the time series variation in the premium of the ADR prices. Our results confirm that imputation tax differences are a significant determinant of the premium. Our paper hence provides direct evidence that imputation tax credits are capitalised into equity prices.
Recreational cannabis legalization and transitions in cannabis use: findings from a nationally representative longitudinal cohort in the United States
Authors: Gunadi Christian , Zhu Bin , Shi Yuyan 
Published: May 2022

AbstractAimsThis study estimated the likelihoods of individuals transitioning to different cannabis use status following recreational cannabis legalization (RCL) in the United States.DesignSecondary analysis of a nationally representative longitudinal cohort in the United States. We used propensity score matching to balance individual characteristics between RCL and comparison states and generalized mixed regressions to estimate behavioral transitions in matched samples.ParticipantsA longitudinal cohort of 21 863 individuals (6925 youths and 14 938 adults) participating in the Population Assessment of Tobacco and Health waves 3 and 4.SettingFour RCL states that implemented RCL between waves 3 and 4 (California, Massachusetts, Nevada and Maine) and comparison states in the United States.MeasurementsTransitions in cannabis use over the two waves: (1) from non‐users to users; (2) from non‐users to weekly users; (3) from users to non‐users. Individuals in RCL states were compared with matched individuals in (1) states with medical cannabis legalization (MCL), (2) states not legalizing cannabis (non‐legalizing) and (3) MCL and non‐legalizing states combined.FindingsAmong youths, the association between RCL and greater odds of transition from non‐users to users was seen in comparison with non‐legalizing states [odds ratio (OR) = 2.18, 95% confidence interval (CI) = 1.37–3.45] and combined states (OR = 1.73, 95% CI = 1.23–2.42). Evidence was lacking regarding the associations between RCL and transitions from non‐users to weekly users and from users to non‐users. Among adults, RCL was associated with greater odds of transitions from non‐users to users and non‐users to weekly users if RCL states were compared with non‐legalizing states (OR = 1.68, 95% CI = 1.15–2.46; OR = 1.82, 95% CI = 1.00–3.31, respectively) or combined states (OR = 1.51, 95% CI = 1.11–2.07; OR = 2.09, 95% CI = 1.19–3.66, respectively). RCL was also associated with lower odds of transition from users to non‐users if RCL states were compared with non‐legalizing states (OR = 0.54, 95% CI = 0.35–0.81).ConclusionsThere appears to be some evidence that recreational cannabis legalization in the United States is associated with elevated odds of transition to cannabis use among both youths and adults.
Influence of combined phacovitrectomy without tamponade on intraocular lens displacement and postoperative refraction
Authors: Mayer‐Xanthaki Christoph F. , Hirnschall Nino , Gabriel Maximilian , Großpötzl Manuel , Wallisch Fabian , Findl Oliver , Haas Anton 
Published: May 2022

AbstractPurposeTo compare phacoemulsification versus phacovitrectomy regarding postoperative intraocular lens (IOL) shift and refraction.MethodsThis prospective bilateral comparison study included 40 eyes of 20 patients. Inclusion criteria were combined phacovitrectomy without gas/air tamponade in one eye and cataract surgery in the contralateral eye with implantation of the same IOL. Postoperative anterior chamber depth (ACD) was compared between both groups 1–5 hr, 1 day and 8 weeks after surgery. Postoperative refraction was compared after 8 weeks using the Holladay I, HofferQ, SRK/T, Haigis and Barrett formulae.ResultsThere were no intergroup differences in ACD (8 weeks: 0.02 mm absolute difference, SD 0.22, range −0.36 to 0.65, p = 0.401), mean absolute refractive error (8 weeks: Holladay I p = 0.452; HofferQ p = 0.475; SRK/T p = 0.498; Haigis p = 0.869; and Barrett p = 0.352) or percentages within the 0.5 D and 1.0 D range at any time‐point. All formulae were optimized for the phacovitrectomy and the cataract groups. There was no correlation of macular thickness change and refractive error (cataract group r2 = −0.13, p = 0.58; phacovitrectomy group r2 = −0.10, p = 0.68).ConclusionCombined phacovitrectomy without air/ gas tamponade caused neither ACD displacement nor refractive shifts compared to phacoemulsification alone. Surgically induced macular thickness change had no significant influence on postoperative refraction in this study. All five IOL formulae showed comparable postoperative refractive outcomes.