bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Anticanonical Complex for Non-degenerate Toric Complete Intersections
Authors: Hausen Jürgen , Mauz Christian , Wrobel Milena 
Published: July 2022

AbstractThe anticanonical complex generalizes the Fano polytope from toric geometry and has been used to study Fano varieties with torus action so far. We provide an explicit description of the anticanonical complex for complete intersections in toric varieties defined by non-degenerate systems of Laurent polynomials. As an application, we classify the terminal Fano threefolds that are embedded into a fake weighted projective space via a general system of Laurent polynomials.
Homogenization of a Locally Periodic Oscillating Boundary
Authors: Aiyappan S. , Pettersson K. 
Published: July 2022

AbstractThis paper deals with the homogenization of a mixed boundary value problem for the Laplace operator in a domain with locally periodic oscillating boundary. The Neumann condition is prescribed on the oscillating part of the boundary, and the Dirichlet condition on a separate part. It is shown that the homogenization result holds in the sense of weak $$L^2$$

L
2

convergence of the solutions and their flows, under natural hypothesis on the regularity of the domain. The strong $$L^2$$

L
2

convergence of average preserving extensions of the solutions and their flows is also considered.
Exploring links between personality traits and their social and non-social environments in wild poison frogs
Authors: Peignier Mélissa , Araya-Ajoy Yimen G. , Bégué Lauriane , Chaloupka Sarah , Dellefont Katharina , Leeb Christoph , Walsh Patrick , Ringler Max , Ringler Eva 
Published: July 2022

Abstract
An animal’s behavioral phenotype comprises several traits, which are hierarchically structured in functional units. This is manifested in measured behaviors often being correlated, partly reflecting the need of a coordinated functional response. Unfortunately, we still have limited understanding whether consistent differences in animal behaviors are due to underlying physiological constraints or a result of plastic adaptation to their current environment. Therefore, characterizing the spatial distribution of behaviors can provide important insights into causes and consequences of behavioral variation. In the present study, we quantified behaviors in a wild, free-ranging population of the Neotropical frog Allobates femoralis. We investigated how these behaviors were linked to the frogs’ natural and social environment and quantified the extent to which these behaviors consistently differed among individuals (i.e., animal personality). We assessed levels of aggressiveness, exploration, and boldness by measuring several underlying behaviors expressed in a set of experimental assays, and found evidence for consistent among-individual differences along these axes. Contrary to our expectation, there was no relationship between individual behaviors and their natural environment, but we found a plastic response of males to changes in female density, which might reflect how individuals cope with their socio-ecological environment.

Significance statement
How are behavioral phenotypes distributed across space? Here, we studied an entire free-ranging population of poison frogs, and investigated if the personality traits aggressiveness, exploration, and boldness are linked to the frogs’ natural or social environment. We found that behavioral traits were non-randomly distributed across the population, suggesting that the spatial arrangement of behavioral traits reflects how individuals cope with their complex natural and social environment.
Retromesenteric Omental Flap for Complete Arterial Coverage During Pancreaticoduodenectomy: Surgical Technique
Authors: Marique Lancelot , Codjia Tatiana , Sauvanet Alain 
Published: July 2022

AbstractPostoperative pancreatic fistula is a frequent complication of pancreaticoduodenectomy that can trigger arterial lesions resulting in post‐pancreatectomy hemorrhage (PPH) in up to 10–15% of cases. We describe an original omental flap technique including mobilization of the greater omentum through the retromesenteric window allowing coverage of all exposed peripancreatic arteries before reconstruction. This technique, used in 146 patients, did not carry any specific morbidities except for one case of partial flap necrosis treated conservatively and was associated with a significant reduction in grade B/C PPH.
A three-field phase-field model for mixed-mode fracture in rock based on experimental determination of the mode II fracture toughness
Authors: Hug L. , Potten M. , Stockinger G. , Thuro K. , Kollmannsberger S. 
Published: July 2022

AbstractIn this contribution, a novel framework for simulating mixed-mode failure in rock is presented. Based on a hybrid phase-field model for mixed-mode fracture, separate phase-field variables are introduced for tensile (mode I) and shear (mode II) fracture. The resulting three-field problem features separate length scale parameters for mode I and mode II cracks. In contrast to the classic two-field mixed-mode approaches, it can thus account for different tensile and shear strength of rock. The two phase-field equations are implicitly coupled through the degradation of the material in the elastic equation, and the three fields are solved using a staggered iteration scheme. For its validation, the three-field model is calibrated for two types of rock, Solnhofen Limestone and Pfraundorfer Dolostone. To this end, double-edge notched Brazilian disk (DNBD) tests are performed to determine the mode II fracture toughness. The numerical results demonstrate that the proposed phase-field model is able to reproduce the different crack patterns observed in the DNBD tests. A final example of a uniaxial compression test on a rare drill core demonstrates that the proposed model is able to capture complex, 3D mixed-mode crack patterns when calibrated with the correct mode I and mode II fracture toughness.
CAS FGOALS-f3-H Dataset for the High-Resolution Model Intercomparison Project (HighResMIP) Tier 2
Authors: An Bo , Yu Yongqiang , Bao Qing , He Bian , Li Jinxiao , Luan Yihua , Chen Kangjun , Zheng Weipeng 
Published: July 2022

AbstractFollowing the High-Resolution Model Intercomparison Project (HighResMIP) Tier 2 protocol under the Coupled Model Intercomparison Project Phase 6 (CMIP6), three numerical experiments are conducted with the Chinese Academy of Sciences Flexible Global Ocean-Atmosphere-Land System Model, version f3-H (CAS FGOALS-f3-H), and a 101-year (1950–2050) global high-resolution simulation dataset is presented in this study. The basic configuration of the FGOALS-f3-H model and numerical experiments design are briefly described, and then the historical simulation is validated. Forced by observed radiative agents from 1950 to 2014, the coupled model essentially reproduces the observed long-term trends of temperature, precipitation, and sea ice extent, as well as the large-scale pattern of temperature and precipitation. With an approximate 0.25° horizontal resolution in the atmosphere and 0.1° in the ocean, the coupled models also simulate energetic western boundary currents and the Antarctic Circulation Current (ACC), reasonable characteristics of extreme precipitation, and realistic frontal scale air-sea interaction. The dataset and supporting detailed information have been published in the Earth System Grid Federation (ESGF, https://esgf-node.llnl.gov/projects/cmip6/).
Emilia-Romagna Surgical Colorectal Cancer Audit (ESCA): a value-based healthcare retro-prospective study to measure and improve the quality of surgical care in colorectal cancer
Authors: Massa Ilaria , Ghignone Federico , Ugolini Giampaolo , Ercolani Giorgio , Montroni Isacco , Capelli Patrizio , Garulli Gianluca , Catena Fausto , Lucchi Andrea , Ansaloni Luca , Gentili Nicola , Danesi Valentina , Montella Maria Teresa , Altini Mattia ,   The ESCA Collaborative Group, Balzi William , Roncadori Andrea , Ferri Giacomo , Gallo Simona , Di Genova Giuseppa , Albertini Nicola , Zattoni Davide , Bolzon Stefano , Avanzolini Andrea , Cavaliere Davide , Di Pietrantonio Daniela , Solaini Leonardo , Chiarella Leonardo Luca , Taffurelli Giovanni , Mazzotti Federico , Frascaroli Giacomo , Pasini Francesco , Di Candido Francesca , Banchini Filippo , Romboli Andrea , Palmieri Gerardo , Conti Luigi , Luzietti Enrico , Portinari Mattia , Pirrera Basilio , Fantini Enrico , Francesco Monari , Palini Gianmarco , Stacchini Giacomo , Sguera Alessandra , Picariello Erika , Faccani Enrico , Gurioli Chiara , Vitali Giulia , Grassia Michele , Agostinelli Laura , Romeo Luigi , Senatore Gianluca 
Published: July 2022

Abstract
Purpose
Surgery is the main treatment for non-metastatic colorectal cancer. Despite huge improvements in perioperative care, colorectal surgery is still associated with a significant burden of postoperative complications and ultimately costs for healthcare organizations. Systematic clinical auditing activity has already proven to be effective in measuring and improving clinical outcomes, and for this reason, we decided to evaluate its impact in a large area of northern Italy.

Methods
The Emilia-Romagna Surgical Colorectal Audit (ESCA) is an observational, multicentric, retro-prospective study, carried out by 7 hospitals located in the Emilia-Romagna region. All consecutive patients undergoing surgery for colorectal cancer during a 54-month study period will be enrolled. Data regarding baseline conditions, preoperative diagnostic work-up, surgery and postoperative course will be collected in a dedicated case report form. Primary outcomes regard postoperative complications and mortality. Secondary outcomes include each center’s adherence to the auditing (enrolment rate) and evaluation of the systematic feedback activity on key performance indicators for the entire perioperative process.

Conclusion
This protocol describes the methodology of the Emilia-Romagna Surgical Colorectal Audit. The study will provide real-world clinical data essential for benchmarking and feedback activity, to positively impact outcomes and ultimately to improve the entire healthcare process of patients undergoing colorectal cancer surgery.

Clinical trial registration
The study ESCA is registered on the clinicaltrials.gov platform (Identifier: NCT03982641).
The accuracy of clinical neck staging for p16-positive and negative oropharyngeal cancer and its therapeutic implications
Authors: Hussain Timon , Thangavelu Kruthika , Kürten Cornelius , Galland Lisa , Höing Benedikt , Deuss Eric , Mattheis Stefan , Lang Stephan , Deuschl Cornelius , Forsting Michael , Dörner Nils 
Published: July 2022

AbstractPurposeOropharyngeal squamous cell carcinoma (OPSCC) may be treated with primary surgery or primary (chemo)radiation. While surgery with concurrent neck dissection provides definitive pathological staging of the neck, non-surgical treatment relies on clinical staging for treatment planning. To assess the accuracy of clinical neck staging, we compared clinical to surgical staging after primary surgery in patients with p16-negative and p16-positive OPSCC.MethodsRetrospective analysis of clinical, pathological, and oncologic outcome data of patients with OPSCC treated with primary surgery and bilateral neck dissection. Clinical and pathological nodal status were compared for p16-negative and p16-positive patients. Patients with occult metastatic disease were analyzed in detail.Results95 patients were included.60.5% of p16-negative patients and 66.6% of p16-positive patients had pathologically confirmed metastatic neck disease. p16-positive patients had improved 24-month recurrence-free survival compared to p16-negative patients at 93.3% vs. 69.6%. Pathological N-status differed from clinical N-status in 36.8% of p16-negative patients vs. 31.6% of p16-positive patients. Occult metastatic disease was more common in p16-negative patients at 18.4% vs. 8.8% for p16-positive patients. Clinical detection sensitivity for extranodal extension was low overall; sensitivity was 27.3% and specificity was 91.6% for p16-negative patients vs. 61.5% and 80.0% for p16-positive patients, respectively.ConclusionOur data show a considerable degree of inaccuracy of clinical neck staging results in all OPSCC patients which needs to be taken into consideration during therapy planning. For p16-positive patients, these findings warrant attention in the context of therapy deintensification to avoid undertreatment.
Changes in the pattern of suicides and suicide attempt admissions in relation to the COVID-19 pandemic
Authors: Reif-Leonhard Christine , Lemke Dorothea , Holz Franziska , Ahrens Kira F. , Fehr Christoph , Steffens Markus , Grube Michael , Freitag Christine M. , Kölzer Sarah C. , Schlitt Sabine , Gebhardt Rebekka , Gädeke Theresa , Schmidt Helga , Gerlach Ferdinand M. , Wolff Kira , Stäblein Michael , Hauschild Nora , Beig Inga , Wagner Louisa , Müller Juliane , Verhoff Marcel A. , Schlang Christiane , Reif Andreas 
Published: July 2022

AbstractThe consequences of the current COVID-19 pandemic for mental health remain unclear, especially regarding the effects on suicidal behaviors. To assess changes in the pattern of suicide attempt (SA) admissions and completed suicides (CS) in association with the COVID-19 pandemic. As part of a longitudinal study, SA admissions and CS are systematically documented and analyzed in all psychiatric hospitals in Frankfurt/Main (765.000 inhabitants). Number, sociodemographic factors, diagnoses and methods of SA and CS were compared between the periods of March–December 2019 and March–December 2020. The number of CS did not change, while the number of SA significantly decreased. Age, sex, occupational status, and psychiatric diagnoses did not change in SA, whereas the percentage of patients living alone while attempting suicide increased. The rate and number of intoxications as a SA method increased and more people attempted suicide in their own home, which was not observed in CS. Such a shift from public places to home is supported by the weekday of SA, as the rate of SA on weekends was significantly lower during the pandemic, likely because of lockdown measures. Only admissions to psychiatric hospitals were recorded, but not to other institutions. As it seems unlikely that the number of SA decreased while the number of CS remained unchanged, it is conceivable that the number of unreported SA cases increased during the pandemic. Our data suggest that a higher number of SA remained unnoticed during the pandemic because of their location and the use of methods associated with lower lethality.
Seventy years of tensegrities (and counting)
Authors: Micheletti Andrea , Podio-Guidugli Paolo 
Published: July 2022

AbstractWe try to make a long way short by proceedingper exemplafrom Kenneth Snelson’s sculptures and Richard Buckminster Fuller’s coinage of the termtensegrityto modern tensegrity metamaterials. We document the passage from initial interest in tensegrity frameworks for their visual impact to today’s interest, driven by their peculiar structural performances. In the past seventy years, the early art pieces and roofing structural complexes have been followed by formalization of the principles governing the form-finding property of ‘pure’ tensegrity structures and by engineering hybridization leading to a host of diverse practical applications, such as variable-geometry civil engineering structures, on-earth and in-orbit deployable structures and robots, and finally to recent and promising studies on tensegrity metamaterials and small-scale tensegrity structures.
Comparative study of three common bile duct closure techniques after choledocholithotomy: safety and efficacy
Authors: Omar Mohammed Ahmed , Redwan Alaa Ahmed , Alansary Marwa Nasrelden 
Published: July 2022

Abstract
Purpose
T-tube drainage, primary closure, and biliary stenting are the common bile duct closure methods. There is great debate on the optimal duct closure technique after common bile duct exploration. This study aimed to assess the safety and efficacy of the three commonest common bile duct closure methods after common bile duct exploration for common bile duct stone for future generalization.

Methods
In this analysis, 211 patients with common bile duct stone underwent common bile duct exploration from January 2016 to December 2020. The patients were divided according to common bile duct closure techniques into three groups, including the T-tube drainage group (63 patients), primary duct closure group (61 patients), and antegrade biliary stenting group (87 patients).

Results
The incidence of overall biliary complications and bile leak were statistically significantly lower in the biliary stenting group than in the other two groups. Also, hospital stays, drain carried time, return to normal activity, re-intervention, and re-admission rates were statistically significantly lower in the biliary stenting group than in the other two groups. There were no statistically significant differences regarding operative and choledochotomy time, retained and recurrent stone, stricture, biliary peritonitis, cholangitis, and the cost among the three groups.

Conclusions
We state that the biliary stenting procedure should be the preferred first option for common bile duct closure after common bile duct exploration when compared with T-tube drainage and primary duct closure.

Trial registration
ClinicalTrials.gov PRS (Approval No. NCT04264299).
Regulation of mitochondrial temperature in health and disease
Authors: El-Gammal Zaynab , Nasr Mohamed A. , Elmehrath Ahmed O. , Salah Radwa A. , Saad Shams M. , El-Badri Nagwa 
Published: July 2022

AbstractMitochondrial temperature is produced by various metabolic processes inside the mitochondria, particularly oxidative phosphorylation. It was recently reported that mitochondria could normally operate at high temperatures that can reach 50℃. The aim of this review is to identify mitochondrial temperature differences between normal cells and cancer cells. Herein, we discussed the different types of mitochondrial thermosensors and their advantages and disadvantages. We reviewed the studies assessing the mitochondrial temperature in cancer cells and normal cells. We shed the light on the factors involved in maintaining the mitochondrial temperature of normal cells compared to cancer cells.
Relaxin does not prevent development of hypoxia-induced pulmonary edema in rats
Authors: Kowalleck Ute , Ahmed Mohamed A. Abdalla , Koedel Julia , Schierle Katrin , Salameh Aida , Rassler Beate 
Published: July 2022

AbstractAcute hypoxia impairs left ventricular (LV) inotropic function and induces development of pulmonary edema (PE). Enhanced and uneven hypoxic pulmonary vasoconstriction is an important pathogenic factor of hypoxic PE. We hypothesized that the potent vasodilator relaxin might reduce hypoxic pulmonary vasoconstriction and prevent PE formation. Furthermore, as relaxin has shown beneficial effects in acute heart failure, we expected that relaxin might also improve LV inotropic function in hypoxia. Forty-two rats were exposed over 24 h to normoxia or hypoxia (10% N2in O2). They were infused with either 0.9% NaCl solution (normoxic/hypoxic controls) or relaxin at two doses (15 and 75 μg kg−1 day−1). After 24 h, hemodynamic measurements and bronchoalveolar lavage were performed. Lung tissue was obtained for histological and immunohistochemical analyses. Hypoxic control rats presented significant depression of LV systolic pressure by 19% and of left and right ventricular contractility by about 40%. Relaxin did not prevent the hypoxic decrease in LV inotropic function, but re-increased right ventricular contractility. Moreover, hypoxia induced moderate interstitial PE and inflammation in the lung. Contrasting to our hypothesis, relaxin did not prevent hypoxia-induced pulmonary edema and inflammation. In hypoxic control rats, PE was similarly distributed in the apical and basal lung lobes. In relaxin-treated rats, PE index was 35–40% higher in the apical than in the basal lobe, which is probably due to gravity effects. We suggest that relaxin induced exaggerated vasodilation, and hence pulmonary overperfusion. In conclusion, the results show that relaxin does not prevent but rather may aggravate PE formation.
Mapping lesion, structural disconnection, and functional disconnection to symptoms in semantic aphasia
Authors: Souter Nicholas E. , Wang Xiuyi , Thompson Hannah , Krieger-Redwood Katya , Halai Ajay D. , Lambon Ralph Matthew A. , Thiebaut de Schotten Michel , Jefferies Elizabeth 
Published: July 2022

AbstractPatients with semantic aphasia have impaired control of semantic retrieval, often accompanied by executive dysfunction following left hemisphere stroke. Many but not all of these patients have damage to the left inferior frontal gyrus, important for semantic and cognitive control. Yet semantic and cognitive control networks are highly distributed, including posterior as well as anterior components. Accordingly, semantic aphasia might not only reflect local damage but also white matter structural and functional disconnection. Here, we characterise the lesions and predicted patterns of structural and functional disconnection in individuals with semantic aphasia and relate these effects to semantic and executive impairment. Impaired semantic cognition was associated with infarction in distributed left-hemisphere regions, including in the left anterior inferior frontal and posterior temporal cortex. Lesions were associated with executive dysfunction within a set of adjacent but distinct left frontoparietal clusters. Performance on executive tasks was also associated with interhemispheric structural disconnection across the corpus callosum. In contrast, poor semantic cognition was associated with small left-lateralized structurally disconnected clusters, including in the left posterior temporal cortex. Little insight was gained from functional disconnection symptom mapping. These results demonstrate that while left-lateralized semantic and executive control regions are often damaged together in stroke aphasia, these deficits are associated with distinct patterns of structural disconnection, consistent with the bilateral nature of executive control and the left-lateralized yet distributed semantic control network.