bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report of Curtobacterium isolated from a catheter tip sample misidentified as Cronobacter
Authors: Braga L.M.P.S. , Saad B.A.A. , de Oliveira C.T.F. , Volpe-Chaves C.E. , Lacerda M.L.G.G. , Forsythe S.J. , Venturini J. , de Oliveira S.M.V.L. , Paniago A.M.M. , da Costa L.V. , de Miranda R.V.S.L. , dos Reis C.M.F. , Brandão M.L.L. 
Published: May 2022

AbstractThe Curtobacterium genus is a member of the family Microbacteriaceae, and Curtobacterium species are recognized as plant pathogens. The aim of this study was to investigate a dubious result of species identification for an infection located on a catheter tip of a patient with Covid-19. A strain isolated from a catheter tip sample, identified by VITEK® 2 as Cronobacter spp., was submitted to polyphasic analysis: Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) using VITEK® MS, real-time polymerase chain reaction targeting dnaG gene, and 16S rRNA full gene Sanger sequencing analysis for confirmation. The strain presented negative result using qPCR and could not identified by MALDI-TOF MS. 16S rRNA full gene Sanger sequencing analysis identified the strain as Curtobacterium spp. The Gram-variable characteristic (Gram-negative instead of Gram-positive) of the isolated strain was the responsible for the misidentification by VITEK® 2 and VITEK® MS did not identify the strain. 16S rRNA full gene sequencing analysis identified the strain as Curtobacterium genus, but other complementary techniques are necessary to identify at species level.
Hepatic ultrastructural features distinguish paediatric Wilson disease from NAFLD and autoimmune hepatitis
Authors: Alqahtani Saleh A. , Chami Rose , Abuquteish Dua , Vandriel Shannon M. , Yap Charesse , Kukkadi Liyana , Parmar Aishwarya , Mundh Amrita , Roberts Eve A. , Kamath Binita M. , Siddiqui Iram 
Published: May 2022

AbstractBackground and AimsWilson disease (WD) has diverse presentations that frequently mimic other liver diseases. Distinguishing WD from non‐alcoholic fatty liver disease (NAFLD) and autoimmune hepatitis (AIH), can be difficult and has critical implications for medical management. This study aimed to examine the utility of histological features of WD in children compared to those with NAFLD and AIH.MethodsA review of liver biopsy slides was performed in children with a clinical and/or genetic diagnosis of WD, seen at the Hospital for Sick Children between 1981 and 2019 and compared to controls with NAFLD and AIH. 37 children with WD and 37 disease controls (20 NAFLD; 17 AIH) were included. Three pathologists, blind to clinical details and diagnosis, reviewed all liver biopsies to reach consensus. Clinical and histopathologic features were compared between groups.ResultsMost WD cases displayed steatosis or steatohepatitis on histology (34/37), active AIH‐pattern in 1 and inactive cirrhosis in 2 cases. Electron microscopy (EM) findings of mitochondrial abnormalities including dilated tips of cristae, pleomorphism, membrane duplication and dense matrix were more frequent in the WD group as compared to disease controls (p < 0.0001). In WD, dilated tips of mitochondrial cristae had a sensitivity of 91% and specificity of 86%, best among EM features.ConclusionsLight microscopic findings display considerable overlap among children with WD, NAFLD and AIH. Ultrastructural findings of mitochondrial abnormalities are important to distinguish WD from NAFLD and AIH. EM examination should be considered essential in the diagnostic work‐up of paediatric liver biopsies.
Social relations and employees' rejection of working from home: A social exchange perspective
Authors: Mergener Alexandra , Trübner Miriam 
Published: May 2022

AbstractWhy do employees prefer working on‐site rather than working from home (WfH)? This article examines how personal concerns at the level of social relationships affect rejection of WfH. Using a large‐scale representative survey of employees in Germany (N = 4448), we apply logistic regression analyses to examine, first, the association between employees' social relationships at work and rejection of WfH and, second, the moderating effects of social relations in the private sphere. Results indicate that the quality of the working atmosphere with colleagues and the supervisor is a motive for rejecting WfH, more so for people living alone than for couples and families. Changes in working culture due to widespread use of new technology and digital mobile devices and, not least, the extensive experiences with WfH during the Covid‐19 pandemic, highlight the relevance of considering employees' workplace preferences in future research.
Well‐posedness of solutions for a class of quasilinear wave equations with strong damping and logarithmic nonlinearity
Authors: Ding Hang , Zhou Jun 
Published: May 2022

AbstractThis paper investigates the well‐posedness of solutions for the following quasilinear wave equation with strong damping and logarithmic nonlinearity in a bounded domain with homogeneous Dirichlet boundary: , where . By virtue of the classical Faedo–Galerkin method and some technical efforts, we first establish the local well‐posedness of solutions. Then we discuss the dynamical behaviors of solutions in detail:

When and , we show that the solutions exist globally with subcritical and critical initial energy, where denotes the Nehari functional with the initial value u0. Especially, under further suitable assumptions about the initial data, we show that the energy functional decays exponentially.

When and , we show that the solutions blow up in finite time with subcritical and critical initial energy. Moreover, by removing the restriction , we prove that the solutions may blow up in finite time with arbitrary high initial energy. In particular, we derive the upper and lower bounds of the blow‐up time.

When and , we show that the maximal existence time of solutions can be extended to infinity and the solutions blow up at infinity with subcritical, critical, and arbitrary high initial energy.
Quality indicators in hemodialysis: A 5‐year experience of national campaigns in France
Authors: Lazareth Hélène , Capuano Frédéric , Calmus Sophie , Erbault Marie , Morin Sandrine , Thervet Eric , May‐Michelangeli Laetitia , Grenier Catherine 
Published: May 2022

AbstractBackground: End stage kidney disease (ESKD) is associated with increased morbidity and mortality. Hemodialysis (HD) is the main technique used for kidney replacement therapy. Dialyzed patients are expected to live less than one half as long as their counterparts without ESKD. Improving quality of care may help to improve mortality in this population. Methods: The French National Authority for Health has carried out three consecutive national campaigns over 5 years for the assessment of quality indicators (QCI) during HD. QCI included anemia management, iron status evaluation, nutritional status assessment, and annual transplantation access. Results: From 2013 to 2017, 227 health facilities participated, and 33,319 files were analyzed. Median age was 72 years old (IQR25–75 = 61–81), and 58.25% of patients were men. Median time in HD was 39.4 months (IQR25–75 = 20.7–72.7). Most of the patients underwent in‐center HD (85.41%). Overweight and obese patients accounted, respectively, for 28.39% and 21.32%, and malnutrition was present in 38.61%. A contra‐indication for renal transplantation was found in 68.3% of patients. All QCI improved over 5 years. Conclusion: Developing QCI based on guidelines is crucial to assure appropriate care of HD patients. Repeating campaigns over 5 years in France improves the quality of care among physicians.
Enhancing inter‐organizational collaboration for wildlife disease surveillance in Sri Lanka
Authors: Kolla Rebecca A. , Lokugalappatti Loku Galappattige Sampath , Clark Douglas A. , Brook Ryan K. 
Published: May 2022

AbstractManagement of zoonotic infectious diseases is an urgent global heath imperative. Interdisciplinary approaches for zoonosis management exist in literature, but collaboratively implementing them is a pervasive challenge. The Sri Lanka Wildlife Health Centre (SLWHC) was created in 2011 to coordinate wildlife disease surveillance and response among government agencies. We interviewed SLWHC‐affiliated personnel about existing communication and collaboration channels to identify operational needs as well as potential enhancements for the SLWHC's operations. We used the Policy Sciences' analytical framework to identify opportunities and challenges for the SLWHC. Study participants held both human and animal health as the utmost priorities. However, their observations indicate that inter‐organizational communication barriers and intra‐organizational hierarchies still need to be overcome for the Centre's partnering organizations to collaborate to their fullest potential. Any interventions to enhance the SLWHC's collaborative capacity for detecting and managing zoonotic disease outbreaks could be strengthened by appealing to participants' shared value orientations towards enlightenment and respect. A common interest was the desire to collaborate and combine resources, knowledge and personnel to detect, reduce and prevent the incidence of zoonotic disease outbreaks in Sri Lanka. These lessons about institutionalizing communication have considerable relevance for organizational responses to the current SARS‐CoV2 pandemic and other zoonoses.
Operational Space Iterative Learning Control of Coupled Active/Passive Multilink Cable-Driven Hyper-Redundant Robots
Authors: Peng Jianqing , Wu Haoxuan , Lau Darwin 
Published: May 2022

Abstract
The operational space control (OSC) of multilink cable-driven hyper-redundant robots (MCDHRs) is required to perform tasks in many applications. As a new coupled active-passive (CAP) MCDHR system, due to the multiple couplings between the active cables, the passive cables, the joints, and the end-effector, the OSC becomes more and more complicated. However, there is currently no robust and effective control method to solve the OSC problem of such types MCDHRs. In this paper, an OSC framework of CAP-MCDHRs using a dynamics-based iterative-learning-control (ILC) method is proposed, considering multivariate optimization. First, the multi-coupling kinematics and the series-parallel coupling dynamics equation (i.e., cable-joint-end) of the CAP-MCDHR are derived. Then, a dynamics-based trajectory tracking framework was constructed. Moreover, an OSC accuracy evaluation model based on a high-precision laser tracker was also designed. The framework allows the tracking of operational space trajectories (OSTs) online with the feasible cable tension and the joint angle. It is also shown that the tracking performance can be improved through the ILC when the desired trajectory is repeatedly performed. Finally, a simulation and an experimental hardware system are built. The results show that the proposed control framework can be easily and effectively applied to the CAP-MCDHR used in real-time.
Design of Adjustable Constant Force/Torque Mechanisms for Medical Applications
Authors: Cheng Zhuoqi , Savarimuthu Thiusius Rajeeth , Foong Shaohui , Tan U-Xuan 
Published: May 2022

Abstract
Safe tool-tissue interaction is critical in medicine. The exerted force or torque on the tissue is required to be under control. This paper presents a design framework for producing simple mechanisms with adjustable constant force or torque. The constant load is generated by paralleling a positive constant stiffness spring and a negative constant stiffness mechanism. The combined output load can be tuned by simply changing the preload of the positive stiffness spring. Also, an algorithm is proposed as a key component of the design framework for assisting the design of the negative stiffness mechanism. By determining a prescribed stiffness that meets the requirement of the application, the proposed algorithm which consists of a finite element simulation (FES) and genetic algorithm (GA) seeks a proper beam structure through iterative optimization automatically. Two example applications are provided to demonstrate the effectiveness of using the design method in satisfying medical needs. Specifically, one translational application and one rotational application are used to show the capability and the versatility of the design framework. According to the experimental results of both examples, the produced mechanisms are able to output a required constant load along the target displacement consistently, and the output load magnitude can be controlled online.
Front Matter
Authors: Kiefner J. F. , Clark E.B. 
Published: May 2022

This front matter contains the Disclaimer, List of Publications ASME Center for Research and Technology Development and Table of Contents. It is available for access by clicking on the PDF icon below.
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Intraoperative acute compartment syndrome of the upper limb secondary to extravasation
Authors: Ang Andrew , Michaelides Athena , Hallworth Stephen , Kocher Hemant M 
Published: May 2022

A woman in her 50s was undergoing a repeat liver resection surgery for recurrence of liver metastasis when the intravenous fluid flow was noted to be sluggish on multiple occasions. On the third examination of the right hand where the intravenous cannula was located, surgery was halted as there was extensive swelling from the hand to the biceps and the hand had started turning blue. A diagnosis of acute upper limb compartment syndrome secondary to extravasation exacerbated by metaraminol was made by the anaesthetist and surgeon. Fasciotomies of the right upper limb were performed, and perfusion was restored. A hand surgeon arrived shortly after and completed decompressing the upper limb compartments.A literature review revealed risk factors such as communication barriers, age and chemotherapy were present in this case. Enhanced monitoring is needed in the context of unsatisfactory infusion flow rates perioperatively.
Choriocapillaris flow deficit and the risk of referable diabetic retinopathy: a longitudinal SS-OCTA study
Authors: Wang Wei , Cheng Weijing , Yang Shaopeng , Chen Yifan , Zhu Zhuoting , Huang Wenyong 
Published: May 2022

AimsTo investigate the association between the choriocapillaris flow deficit percentage (CC FD%) and the 1-year incidence of referable diabetic retinopathy (RDR) in participants with type 2 diabetes mellitus (DM).MethodsThis prospective cohort study included participants with type 2 DM. The DR status was graded based on the ETDRS-7 photography. The CC FD% in the central 1 mm area, inner circle (1.5 mm to 2.5 mm), outer circle (2.5 mm to 5.0 mm) and the entire area in the macular region were measured using swept-source optical coherence tomography angiography (SS-OCTA). Logistic regression analysis was used to examine the association between baseline CC FD% and 1-year incident RDR.ResultsA total of 1222 patients (1222 eyes, mean age: 65.1±7.4 years) with complete baseline and 1-year follow-up data were included. Each 1% increase in baseline CC FD% was significantly associated with a 1.69 times (relative risk 2.69; 95% CI 1.53 to 4.71; p=0.001) higher odds for development of RDR after 1-year follow-up, after adjusting for other confounding factors.ConclusionsA greater baseline CC FD% detected by SS-OCTA reliably predicted higher risks of RDR in participants with type 2 DM. Thus, CC FD% may act as a novel biomarker for predicting the onset and progression of DR.
Workflow and treatment results for computer-aided design and 3D-printed conformer therapy of congenital anophthalmia and microphthalmia
Authors: Groot Annabel L W , Remmers Jelmer S , Lissenberg-Witte Birgit I , de Meulenaere Simon T J , Talan Duygu , Liberton Niels P T J , de Graaf Pim , Moll Annette C , Saeed Peerooz , Hartong Dyonne T 
Published: May 2022

Background/aimsTo evaluate treatment with custom, three-dimensional (3D) printed conformers for socket expansion in congenital microphthalmia and anophthalmia (MICA).MethodsRetrospective analysis of prospective cohort from 2016 to 2020. All children received custom-made 3D-printed conformers increasing in size. We measured height, width, thickness, surface and volume of first and consecutive conformers, as well as horizontal palpebral fissure length (HPF) at start and follow-up visits. We analysed these parameters for severely (<45%) and moderately (>45%–75%) affected children, based on affected axial length on ultrasonography.ResultsWe included 18 cases (9 severe, 9 moderate) with a total of 174 conformers (88 severe, 86 moderate) and a mean follow-up of 2.8 years (range 1.3–4.8). The mean relative HPF increased from 77% to 93% with 16/17 cases reaching >80%, and 12/17 cases >90% symmetry. Horizontal and vertical conformer dimensions increased up to 10 months of treatment, with a steeper slope for the severe group (10.5% vs 5.5% for height and 9.0% vs 6.1% for width gain per treatment month, for severe and moderate MICA, respectively). After 10 months of treatment conformer height and width increased only slightly. No serious complications were observed.Conclusion3D-design and printing of solid conformers results in highly acceptable horizontal eyelid symmetry in the treatment of congenital MICA. The mean increase in conformer height and width in the first 10 months should be about 170% for moderate and about 200% for severe MICA. The presented conformer size formulas can aid ophthalmologists and ocularists to plan conformer treatment.
Prehospital interventions and neurological outcomes in marathon-related sudden cardiac arrest using a rapid mobile automated external defibrillator system in Japan: a prospective observational study
Authors: Tanaka Hideharu , Kinoshi Tomoya , Tanaka Shota , Sagisaka Ryo , Takahashi Hiroyuki , Sone Etsuko , Hara Takahiro , Takeda Yui , Takyu Hiroshi 
Published: May 2022

ObjectiveTo describe neurological outcomes after sudden cardiac arrests (SCAs) in road and long-distance races using a rapid mobile automated external defibrillator system (RMAEDS) intervention.MethodsA total of 42 SCAs from 3 214 701 runners in 334 road and long-distance races from 1 February 2007 to 29 February 2020 were examined. Demographics, SCA interventions, EMS-related data and SCA-related outcomes were measured. Primary endpoints were favourable neurological outcomes (Cerebral Performance Categories 1–2) at 1-month and 1-year post-SCA. Secondary endpoints were factors related to the field return of spontaneous circulation (ROSC) and resuscitation characteristics, including the initial ECG waveform classification and resuscitation sequence times according to the initial ECG rhythm.ResultsThe SCA incidence rate was 1.31 per 100 000 runners (age: median (IQR), 51 (36.5, 58.3) years). Field ROSC and full neurological recovery at 1-month post-SCA was achieved 90.4% and 92.9% of cases, respectively. In 22 cases in which bystander cardiopulmonary resuscitation was initiated within 1 min and defibrillation performed within 3 min, full neurological recovery was achieved at 1-month and 1-year post-SCA in 95.5.% and 95.5% of cases, respectively.ConclusionsThe RMAEDS successfully treated patients with SCA during road and long-distance races yielding a high survival rate and favourable neurological outcomes. These findings support rapid intervention and the proper placement of healthcare teams along the race course to initiate chest compressions within 1 min and perform defibrillation within 3 min.
Continuous glucose monitoring demonstrates low risk of clinically significant hypoglycemia associated with sulphonylurea treatment in an African type 2 diabetes population: results from the OPTIMAL observational multicenter study
Authors: Niwaha Anxious J , Rodgers Lauren R , Carr Alice L J , Balungi Priscilla A , Mwebaze Raymond , Hattersley Andrew T , Shields Beverley M , Nyirenda Moffat J , Jones Angus G 
Published: May 2022

IntroductionPeople living with diabetes in low-resource settings may be at increased hypoglycemia risk due to food insecurity and limited access to glucose monitoring. We aimed to assess hypoglycemia risk associated with sulphonylurea (SU) and insulin therapy in people living with type 2 diabetes in a low-resource sub-Saharan African setting.Research design and methodsThis study was conducted in the outpatients’ diabetes clinics of two hospitals (one rural and one urban) in Uganda. We used blinded continuous glucose monitoring (CGM) and self-report to compare hypoglycemia rates and duration in 179 type 2 diabetes patients treated with sulphonylureas (n=100) and insulin (n=51) in comparison with those treated with metformin only (n=28). CGM-assessed hypoglycemia was defined as minutes per week below 3mmol/L (54mg/dL) and number of hypoglycemic events below 3.0 mmol/L (54 mg/dL) for at least 15 minutes.ResultsCGM recorded hypoglycemia was infrequent in SU-treated participants and did not differ from metformin: median minutes/week of glucose <3 mmol/L were 39.2, 17.0 and 127.5 for metformin, sulphonylurea and insulin, respectively (metformin vs sulphonylurea, p=0.6). Hypoglycemia risk was strongly related to glycated haemoglobin (HbA1c) and fasting glucose, with most episodes occurring in those with tight glycemic control. After adjusting for HbA1c, time <3 mmol/L was 2.1 (95% CI 0.9 to 4.7) and 5.5 (95% CI 2.4 to 12.6) times greater with sulphonylurea and insulin, respectively, than metformin alone.ConclusionsIn a low-resource sub-Saharan African setting, hypoglycemia is infrequent among people with type 2 diabetes receiving sulphonylurea treatment, and the modest excess occurs predominantly in those with tight glycemic control.
Serum metabolomic signatures of gestational diabetes in South Asian and white European women
Authors: Sikorski Claudia , Azab Sandi , de Souza Russell J , Shanmuganathan Meera , Desai Dipika , Teo Koon , Atkinson Stephanie A , Morrison Katherine , Gupta Milan , Britz-McKibbin Philip , Anand Sonia S 
Published: May 2022

IntroductionThis study aimed to identify serum metabolomic signatures associated with gestational diabetes mellitus (GDM), and to examine if ethnic-specific differences exist between South Asian and white European women.Research design and methodsProspective cohort study with a nested case–control analysis of 600 pregnant women from two Canadian birth cohorts; using an untargeted approach, 63 fasting serum metabolites were measured and analyzed using multisegment injection-capillary electrophoresis-mass spectrometry. Multivariate logistic regression modeling was conducted overall and by cohort.ResultsThe proportion of women with GDM was higher in South Asians (27.1%) compared with white Europeans (17.9%). Several amino acid, carbohydrate, and lipid pathways related to GDM were common to South Asian and white European women. Elevated circulating concentrations of glutamic acid, propionylcarnitine, tryptophan, arginine, 2-hydroxybutyric acid, 3-hydroxybutyric acid, and 3-methyl-2-oxovaleric acid were associated with higher odds of GDM, while higher glutamine, ornithine, oxoproline, cystine, glycine with lower odds of GDM. Per SD increase in glucose concentration, the odds of GDM increased (OR=2.07, 95% CI 1.58 to 2.71), similarly for metabolite ratios: glucose to glutamine (OR=2.15, 95% CI 1.65 to 2.80), glucose to creatinine (OR=1.79, 95% CI 1.39 to 2.32), and glutamic acid to glutamine (OR=1.46, 95% CI 1.16 to 1.83). South Asians had higher circulating ratios of glucose to glutamine, glucose to creatinine, arginine to ornithine, and citrulline to ornithine, compared with white Europeans.ConclusionsWe identified a panel of serum metabolites implicated in GDM pathophysiology, consistent in South Asian and white European women. The metabolic alterations leading to larger ratios of glucose to glutamine, glucose to creatinine, arginine to ornithine, and citrulline to ornithine in South Asians likely reflect the greater burden of GDM among South Asians compared with white Europeans.