bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent FOSL1 rearrangements in desmoplastic fibroblastoma
Authors: De Noon Solange , Piggott Robert , Trotman Jamie , Tadross John A , Fittall Matthew , Hughes Debbie , Ye Hongtao , Munasinghe Emani , Murray Matthew , Tirabosco Roberto , Amary Fernanda , Coleman Nicholas , Watkins James , Hubank Michael , Tarpey Patrick , Behjati Sam , Flanagan Adrienne M 
Published: November 2022

AbstractThe FOS gene family has been implicated in tumourigenesis across several tumour types, particularly mesenchymal tumours. The rare fibrous tumour desmoplastic fibroblastoma is characterised by overexpression of FOSL1. However, previous studies using cytogenetic and molecular techniques did not identify an underlying somatic change involving the FOSL1 gene to explain this finding. Prompted by an unusual index case, we report the discovery of a novel FOSL1 rearrangement in desmoplastic fibroblastoma using whole‐genome and targeted RNA sequencing. We investigated 15 desmoplastic fibroblastomas and 15 fibromas of tendon sheath using immunohistochemistry, in situ hybridisation and targeted RNA sequencing. Rearrangements in FOSL1 and FOS were identified in 10/15 and 2/15 desmoplastic fibroblastomas respectively, which mirrors the pattern of FOS rearrangements observed in benign bone and vascular tumours. Fibroma of tendon sheath, which shares histological features with desmoplastic fibroblastoma, harboured USP6 rearrangements in 9/15 cases and did not demonstrate rearrangements in any of the four FOS genes. The overall concordance between FOSL1 immunohistochemistry and RNA sequencing results was 90%. These findings illustrate that FOSL1 and FOS rearrangements are a recurrent event in desmoplastic fibroblastoma, establishing this finding as a useful diagnostic adjunct and expanding the spectrum of tumours driven by FOS gene family alterations. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Effects of wet treatment on bonding strength and electrothermal performance of electrothermal plywood bonded with emulsion polymer‐isocyanate adhesive
Authors: Tao Xin , Tian Dongxue , Liang Shanqing , Zhang Longfei , Li Shanming , Fu Feng 
Published: November 2022

AbstractTo create a green, safe, and aldehyde‐free indoor heating environment, an eco‐friendly emulsion polymer‐isocyanate (EPI) adhesive was applied to the preparation of electrothermal plywood with built‐in carbon fiber paper. The optimized process parameters of electrothermal plywood were 0.9 MPa, 120°C, 6 min, and 200 g/m2 for hot‐pressing pressure, temperature, time, and glue spread amount, respectively. After water immersion for 24 h, the bonding strength of wet‐treated electrothermal plywood decreased to 0.89 MPa. The pull‐out cracks of the carbon fiber paper were the main fracture form of the wet‐treated electrothermal plywood, and the wood failure percentage was 0%–10% under the tensile load. Hydrolysis of the adhesive layer of the wet‐treated electrothermal plywood occurred. The relative C and N contents in the wet‐treated electrothermal plywood decreased by 6.1% and 25.3%, respectively. Moreover, the resistance of the wet‐treated electrothermal plywood increased by 273.4% because the internal conductive path was interrupted during the intrusion of the water molecules. The highest electric‐to‐radiant transfer efficiency of the electrothermal plywood was 72.4%, with a power density of 200 W/m2. In conclusion, wet treatment has a significant effect on the bonding strength and electrothermal performance of the electrothermal plywood bonded with EPI adhesive.
Potentially inappropriate medications in nursing homes and the community older adults using the French health insurance databases
Authors: Drusch Solene , Le Tri Thien , Ankri Joel , Michelon Hugues , Zureik Mahmoud , Herr Marie 
Published: November 2022

AbstractPurposePotentially inappropriate medications (PIMs) have become a major issue in improving prescribing practices and reducing the risk of adverse drug events in older people. However, very few studies have compared exposition to PIMs controlling for differences in demographic and health between nursing home residents (NHRs) and community‐dwelling older adults (CDOAs). This study aimed to assess the prescribing pattern of PIMs between NHRs and CDOAs.MethodsWe conducted a cross‐sectional study over three months in 2019 using the French Health Insurance databases. The study population included 274 971 NHRs and 4 893 721 CDOAs aged 75 years or over. The prevalence ratio (PR) between NHRs and CDOAs of 17 PIM indicators, based on the Beers and STOPP criteria lists, was assessed using multivariable robust Poisson regression adjusted for age, sex, diseases, and polypharmacy.ResultsDuring the study period, 54% of NHRs and 29% of CDOAs received at least one PIM. After adjustment, the prevalence of PIMs was 33% higher among NHRs compared to CDOAs (aPR = 1.33; 95% CI [1.33–1.34]). NHRs received PIMs related to benzodiazepines (aPR = 1.43; 95% CI [1.42–1.43]), anticholinergic drugs (aPR = 1.29; 95% CI [1.27–1.31]), and at least three central nervous system‐active drugs (aPR = 1.94; 95% CI [1.92–1.96]) more frequently. Prevalence of PIMs related to non‐steroidal anti‐inflammatory drugs (aPR = 0.50; 95% CI [0.48–0.52]) and long‐acting benzodiazepines (aPR = 0.84; 95% CI [0.82–0.85]) was lower among NHRs.ConclusionThe NHRs were at greater risk for PIM than CDOAs, although differences exist according to the category of PIMs. As the population is aging, it is essential to promote and evaluate interventions in NHs and the community to enhance medication optimization.
Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes
Authors: Kobayashi Kaoru , Deguchi Tsuneo , Abe Satoshi , Kajitani Naoyo , Kazuki Kanako , Takehara Shoko , Nakamura Kazuomi , Kurihara Atsushi , Oshimura Mitsuo , Kazuki Yasuhiro 
Published: November 2022

AbstractUDP‐glucuronosyltransferases (UGTs) catalyze the conjugation of various substrates with sugars. Since the UGT2 family forms a large cluster spanning 1.5 Mb, transgenic mouse lines carrying the entire human UGT2 family have not been constructed because of limitations in conventional cloning techniques. Therefore, we made a humanized mouse model for UGT2 by chromosome engineering technologies. The results showed that six UGT2 isoforms examined were expressed in the liver of adult humanized UGT2 (hUGT2) mice. Thus, the functions of human UGT2B7 in the liver of hUGT2 mice were evaluated. Glucuronide of azidothymidine (AZT, zidovudine), a typical UGT2B7 substrate, was formed in the liver microsomes of hUGT2 mice but not in the liver microsomes of wild‐type and Ugt2‐knockout mice. When AZT was intravenously administered, AZT glucuronide was detected in the bile and urine of hUGT2 mice, but it was not detected in the bile and urine of wild‐type and Ugt2‐knockout mice. These results indicated that the hUGT2 mice express functional human UGT2B7 in the liver. This finding was also confirmed by using gemfibrozil as an alternative UGT2B7 substrate. Gemfibrozil glucuronide was formed in the liver microsomes of hUGT2 mice and was mainly excreted in the bile of hUGT2 mice after intravenous dosing of gemfibrozil. This hUGT2 mouse model will enable improved predictions of pharmacokinetics, urinary and biliary excretion and drug–drug interactions mediated by human UGT2, at least UGT2B7, in drug development research and basic research.
Ab – initio study on the stability and electronic property of graphene nanosheets: Applications to batteries
Authors: Paramasivam Naveena , Sambandam Anandan , Natesan Baskaran 
Published: November 2022

AbstractThe aim of this work is to improve the electrochemical performance of graphene nanosheets for its potential applications as electrode materials in supercapacitors. In order to achieve this, we have carried out detailed ab – initio based density functional theory calculations on pristine and functionalized graphene nanosheets (containing 8, 18, and 32 carbon atoms) with different functional groups. We considered graphene nanosheets functionalized with groups such as ether, lactone, ketone, and carboxylate in addition to previously studied epoxy and hydroxyl. From the structural optimization, we observed variations in the transverse displacement of carbon atoms, changes in CC and CO bond length, and bond angles. In particular, we noticed when functionalized with lactone CC and CO bonds contracts more which results in excessive surface charge density, and quantum capacitance, This suggest that C32 – functionalized with lactone would be a better candidate for battery electrodes with relatively high and values.
Stochastic stabilization of multi‐degree‐of‐freedom nonlinear random‐time‐delay controlled systems
Authors: Hu Rongchun , Lu Xiang , Zhang Dongxu , Gu Xudong 
Published: November 2022

AbstractThe random‐time‐delay (RTD) occurs inevitably in feedback control, caused by the utilization of a multi‐user network with random demands. This paper is devoted to the stochastic stabilization of multi‐degree‐of‐freedom (MDOF) nonlinear RTD controlled systems. Firstly, a two‐step approximated method is proposed to deal with RTD: by modeling the RTD as a Markov jump process, the RTD control is formulated as the one with discrete jump varying delay; utilizing the randomly periodic characteristic, the Markov jump delay is taken out of the control as a parameter. The stochastic averaging principle is applied to generate a less‐dimensional averaged governing equation of system's energies. Secondly, the dynamical programming principle is applied to the ergodic control problem of the average systems with an undetermined cost function, which is determined by the demand of stabilizing the averaged systems, then the optimal control law is deduced. A largest Lyapunov exponent is introduced to the averaged systems to evaluate the asymptotic stability with probability one. Finally, an example is worked out to demonstrate the application and effectiveness of the proposed method.
Model‐free self‐triggered control based on deep reinforcement learning for unknown nonlinear systems
Authors: Wan Haiying , Karimi Hamid Reza , Luan Xiaoli , Liu Fei 
Published: November 2022

AbstractThis article proposes a joint learning technique for control inputs and triggering intervals of self‐triggered control nonlinear systems with unknown dynamics. First, deep reinforcement learning is introduced to the self‐triggered control system by considering both the control performance and triggering performance in the reward function. Then, the control inputs and triggering intervals are simultaneously learned by the developed deep deterministic policy gradient approach. Under this strategy, not only the desired control performance is guaranteed for unknown nonlinear systems, but also both the computation and communication occupation for the controlled system are decreased without any triggering thresholds. Finally, simulations for the cart‐pole swing‐up system are illustrated to verify the effectiveness of the proposed scheme.
Hydroxymethylfurfural (HMF) Synthesis from Starch with Zeolite Based Catalysts
Authors: Yakupoğlu Şevval , Akmaz Solmaz , Koç Serkan Naci 
Published: November 2022

AbstractIn the study, it is aimed to use effective zeolite‐based catalysts for the synthesis of hydroxymethylfurfural (HMF) from starch in different solvent environments. Al, Zn, and heteropolyacid (HPW) loaded USY zeolites are prepared and characterized using XRD, BET method, Inductive Coupling Plasma Mass Spectrometry (ICP‐MS), Pyridine‐DRIFTS, and X‐ray Photoelectron Spectroscopy (XPS). The efficiency of the prepared catalysts is investigated in 1‐Butyl‐3‐Methylimidazolium Chloride (BMIMCI) ionic liquid, DMSO, and THF solvents at different temperatures and reaction times for HMF synthesis. 24.5% HMF yield using Zn‐USY zeolite and 50.3% HMF yield using USY H‐zeolite is obtained in BMIMCI ionic liquid at 130 °C for 3 h. HMF yield of 47% is obtained using Zn‐USY zeolite catalyst at 160 °C in 4 h, at 170 °C in 2 h, and at 180 °C in 1 h in DMSO. In a two‐phase reaction medium with THF and H2O, the HMF yield is 46.8% at 160 °C in 4 h, 52.2% at 170 °C in 30 min, and 38.1% at 180 °C in 2 h with Zn‐USY zeolite catalyst. The reusability of the Zn‐USY zeolite has been tested and the efficiency of catalyst does not decrease in reuse for five times.
Morphological and Functional Properties of Millet Starches as Influenced by Different Modification Techniques: A Review
Authors: Thakur Kavita , Sharma Savita , Sharma Rajan 
Published: November 2022

AbstractThe growing need for new starches has sparked interest in the expansion of novel starch sources for the food sector. Millets are popular due to various health benefits and sustainability. Similar to the majority of cereals, the major constituent and quality factor of millet grain is its starch, which contributes 60—70% of the whole grain. Utilization of starch is reliant on its structural and functional properties. Starch in its native form does not possess all the required properties such as low temperature and shear stability. The desired properties for food products can achieved by modifying the starch functionality and morphology via physical, chemical, enzymatic, and dual methods. At present, research for potential application of native as well as modified millet starch is limited. The objective of this review is to focus on the techno‐functional and morphological properties, various modification techniques, and applications of the millet starches. The review paper also summaries the applications of modified millet starch in the food industry.
Intramural jejunal haematoma in an Arabian mare as a cause of colic: Clinical presentation, diagnosis and treatment
Authors: Orr Haion , Rabea Haddad , Amos Tatz J. , Ori Brenner , Gal Kelmer 
Published: November 2022

AbstractAn 11‐year‐old Arabian mare was presented to the Veterinary Teaching Hospital, Koret School of Veterinary Medicine because of acute colic. During exploratory laparotomy, a segment of the jejunum was found to be necrotic, with a haematoma on its antimesenteric border. The segment was removed via hand‐sewn resection and anastomosis, and the mare recovered successfully. Histopathology revealed intramural haematoma located in the tunica muscularis. Three years later, the mare is healthy, and is back to its intended use as a brood mare.
Effect of hydraulic retention time on performance of autotrophic, heterotrophic, and split‐mixotrophic denitrification systems supported by polycaprolactone/pyrite: Difference and potential explanation
Authors: Yuan Sicheng , Zhu Wentao , Guo Weijie , Sang Wenjiao , Zhang Shiyang 
Published: November 2022

AbstractBiological denitrification is still the most important pathway to purifying nitrate‐containing wastewater. In this study, pyrite (FeS2) and polycaprolactone (PCL) were used as electron donors to construct sole or combined denitrification systems, that is, pyrite‐based autotrophic denitrification (PAD) system, PCL‐supported heterotrophic denitrification (PHD) system, and split‐mixotrophic denitrification system (combined PAD + PHD), all of which were operated under five different hydraulic retention times (HRTs) for 150 days. The results showed that the removal rates (RE) of nitrate (NO3−‐N) and inorganic phosphorus (PO43−‐P) by PAD were 91% and 94%, respectively, but the effluent sulfate (SO42−) concentration was as high as 168.2 mg/L; the removal rate of NO3−‐N by PHD was higher than 99%, but the PO43−‐P could not be removed ideally; the removal rates of NO3−‐N and PO43−‐P by PAD + PHD were higher than 95% and 99%, respectively, and the effluent SO42− concentration was only 7.2 mg/L. Through the analysis of the surface scanning electron microscope (SEM) images of the two kinds of media before and after use, it was found that the coupled mode of PAD + PHD was more favorable for biofilm formation than the sole PAD or PHD process, and the microorganisms in the PAD + PHD mode made more full use of electron donors. Moreover, the biomass of the PAD + PHD mode was lower than that of the PAD or PHD process, but the denitrification efficiency of the coupled mode was more efficient, indicating that the functional microorganisms in the PAD + PHD mode might have a certain synergistic effect.Practitioner Points
Removal rates of NO3−, PO43−, and SO42− by PAD were 91%, 94%, and −233%, respectively.
Removal rate of NO3− by PHD exceeded 99%, but PO43− could not be removed ideally.
Removal rates of NO3−, PO43−, and SO42− by PAD + PHD were 95%, 99%, and 86%, respectively.
The coupled mode was more favorable for biofilm formation than the sole PAD or PHD.
The coupled mode had lower biomass but got more excellent denitrification efficiency.
Weshalb Subsidiary Governance?
Authors: Renz Patrick , Böhrer Nikola , Peter Marc K. 
Published: November 2022

ZusammenfassungDurch die zunehmende Internationalisierung von Unternehmen wird das Führen über die Landesgrenzen hinaus immer wichtiger. Internationalisierung ist heutzutage für Unternehmen unabhängig von ihrer Größe beinahe eine Grundvoraussetzung, um erfolgreich zu sein. Ziele, die ein Unternehmen mit der Internationalisierung verfolgt, sind bspw. Wachstum durch Erschließung neuer Märkte oder das Auslagern von Teilen der Wertkette und damit die Konzentration auf Kernkompetenzen. Die Digitalisierung bzw. digitale Transformation hat die Möglichkeiten zur Internationalisierung noch stark vergrößert. Zur Erreichung dieser Ziele werden ausländische Niederlassungen (englisch: subsidiaries) gegründet oder Partnerschaften mit Unternehmen anderer Länder eingegangen.
Das Subsidiary Governance Modell
Authors: Renz Patrick , Böhrer Nikola , Peter Marc K. 
Published: November 2022

ZusammenfassungDas Subsidiary Governance Modell (Abb. 2.1) besteht aus sechs Inhaltsmodulen und sechs resultatorientierten Modulen. Die sechs Inhaltsmodule bestimmen den Inhalt bzw. die Grundlage der Subsidiary Governance, weshalb man sie auch „Grundlagenmodule“ nennen kann. Sie beantworten die Frage, welche Themen für gute Führung und Kontrolle einer Subsidiary fundamental und wichtig sind und liefern somit eine Aussage über die Qualität dessen, was in einem Unternehmen vorhanden ist oder nicht. Mit anderen Worten: Die Steuerung und Kontrolle von Niederlassungen muss die Bereiche System, Mission, Integrität, Anspruchsgruppen, Risiko und Audit umfassen. Ohne diese inhaltliche Konkretisierung bleibt Subsidiary Governance ein schwer greifbarer Begriff.
Aspects of irregular punctures via holography
Authors: Bah Ibrahima , Bonetti Federico , Nardoni Emily , Waddleton Thomas 
Published: November 2022

Abstract
We present new families of AdS5 solutions in M-theory preserving 4d $$ \mathcal{N} $$
N
= 2 supersymmetry. We perform a systematic analysis of holographic observables for these solutions, providing evidence for an interpretation in terms of 4d superconformal field theories (SCFTs) of Argyres-Douglas type, realized in class $$ \mathcal{S} $$
S
via a sphere with one irregular, and one regular puncture. The gravity solutions exhibit internal M5-brane sources that correspond to the irregular puncture. For a family of solutions, we identify explicitly the class $$ \mathcal{S} $$
S
puncture data and perform a detailed match, including Higgs branch operators. For other families we comment on proposed field theory duals, based on irregular punctures labeled by nested Young tableaux.
Understanding citizen perceptions of AI in the smart city
Authors: Lehtiö Anu , Hartikainen Maria , Ala-Luopa Saara , Olsson Thomas , Väänänen Kaisa 
Published: November 2022

AbstractArtificial intelligence (AI) is embedded in a wide variety of Smart City applications and infrastructures, often without the citizens being aware of the nature of their “intelligence”. AI can affect citizens’ lives concretely, and thus, there may be uncertainty, concerns, or even fears related to AI. To build acceptable futures of Smart Cities with AI-enabled functionalities, the Human-Centered AI (HCAI) approach offers a relevant framework for understanding citizen perceptions. However, only a few studies have focused on clarifying the citizen perceptions of AI in the context of smart city research. To address this gap, we conducted a two-phased study. In the pre-study, we explored citizen perceptions and experiences of AI with a short survey (N = 91). Second, scenario-based interviews (N = 7) were utilized to gain in-depth insights of citizen perceptions of AI in the Smart City context. Five central themes were recognized: (1) I don’t like them monitoring me, (2) I want maximum gain for minimum effort, (3) I don’t want AI to mimic people, (4) I’ll avoid using AI if I consider the risk too high, and (5) I don’t need to be concerned about AI. These offer an idea of human-centered requirements worth considering while designing AI applications for future Smart Cities.
Computer-aided design and manufacturing technology applied to total nasal reconstruction
Authors: Sgarzani Rossella , Meccariello Giuseppe , Iannella Giannicola , Gessaroli Manlio , Vicini Claudio , Melandri Davide , Morellini Andrea 
Published: November 2022

Abstract
The principles of nasal reconstruction include the need to reconstruct three tissue layers, the need to restore entire skin aesthetical units, and, possibly, the replacement with like tissues. Computer-aided design (CAD) and computer-aided manufacturing (CAM) technologies were applied to two total nasal reconstructions in male patients who underwent rhinectomy for cancer. Three-dimensional (3D) data were obtained from computerized tomography (CT) scan-derived DICOM files (Digital Imaging and Communications in Medicine), this allowed us to design the shape of the reconstructive nose in order to mimic the native nose and to plan dimensions and angles. A custom-made titanium plate was manufactured for the structure and a bi-dimensional template for the forehead flap was printed. The patients underwent a total nasal reconstruction in three layers: local flaps for the lining, custom-made titanium plate for the structure, and expanded forehead flap for the skin. Forehead flap pedicle was divided 3 weeks postoperatively under local anesthesia in an outpatient clinic, as well as further minor refinements. The patients underwent a 6-month post-operative CT scan in order to compare the result to the planned nose. No complications were reported. The superimposition demonstrated a 92% match in case 1 and 95% match in case 2 between the reconstructed nose and the planned one. Forehead flap is still the most favorable option for nasal reconstruction, CAD technology allows to implement the planning and makes the procedure easier; moreover, the use of a CAM plate for the structure allows to reconstruct a nose with the desired naso-frontal angle.Level of evidence: level V, therapeutic study.