bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of NaI background and mass on testing the DAMA modulation
Authors: Zurowski Madeleine J. , Barberio Elisabetta 
Published: December 2022

AbstractWe present here the model dependent and independent sensitivity studies for NaI detectors designed to test the DAMA result, and compare the predicted limits from SABRE with the present performance of both ANAIS and COSINE. We find that the strongest discovery and exclusion limits are set by a detector with the lowest background (assuming equal live times), and also note that our method correctly computes the present exclusion limits previously published by ANAIS and COSINE. In particular, with a target mass of 50 kg and background rate of 0.36 cpd/kg/keV (after veto), SABRE will be able to exclude the DAMA signal with 3$$\sigma $$
σ
confidence or ‘discover’ it with 5$$\sigma $$
σ
confidence within 2 years. This strongly motivates the quest for ever lower backgrounds in NaI detectors.
Clinical Characteristics, Antimicrobial Resistance, and Outcomes of Patients with Invasive Pneumococcal Disease in Ningxia Hui Autonomous Region, China, 2013–2021
Authors: Tao Jia , Wang Wen , Li Gang , Wang Linlin , Wang Liang , Zhao Zhijun , Jia Wei , Wang Liru 
Published: December 2022

Objectives. This study aimed to analyze the clinical features, antibiotic susceptibility profiles, and outcomes of patients with invasive pneumococcal disease (IPD) at a hospital in Ningxia Hui Autonomous Region, to provide the basis for improving the clinical treatment effect. Methods. Patients with IPD were retrospectively collected from 2013 to 2021. Clinical manifestations, laboratory tests, antimicrobial susceptibility, antibiotic treatment, and outcomes of the disease were analyzed. Results. In this study, we identified 127 IPD cases, of whom 49 (38.6%) had meningitis and 78 (61.4%) had bacteremia. The median ages of pediatric cases and adult cases were 2 years (IQR: 0–5) and 52.5 years (IQR: 35–62), respectively. There were 27 and 45 males in the pediatric and adult groups, and no significant gender difference in the different age groups (

p
=
0.584

) was found. Of 75 cases with underlying diseases, pneumonia (11%), malignancy (11%), hypertension (9.4%), and hepatic cirrhosis (7.9%) were the most common. The incidence of underlying diseases was even higher in the adult group (67.1%) than in the pediatric group (47.1%) (

p
=
0.028

). The frequency of fever, cough, and seizures was significantly higher in the pediatric group than in the adult group, with

p

-values of 0.004, 0.004, and 0.001, respectively. The percentage of neutrophils in the blood was significantly higher in the adult cases than in the pediatric cases (

p

<

0.001

). Furthermore, there was a significantly higher WBC count (

p

<

0.001

), percentage of neutrophils (

p
=
0.012

), and protein level (

p
=
0.019

) in the CSF samples in the adult patients compared to pediatric patients. The susceptibility rates of S. pneumoniae isolates to vancomycin, linezolid, and levofloxacin were 100%. The susceptibility rates of penicillin were 98.7% and 34.1% in bacteremia and meningitis patients, respectively. Most isolates were resistant to erythromycin, clindamycin, tetracycline, and azithromycin. The most common antibiotic treatment was β-lactams. Seven (5.5%) patients died during hospitalization, and 38 (29.9%) patients' health deteriorated. Conclusion. These results may provide a reference basis for the diagnosis and empiric treatment of IPD in the region.
Análise da incidência de complicações materno-fetais após o uso dos critérios da IADPSG para o diagnóstico do diabetes gestacional – uma revisão integrativa
Authors: Tsutida Carolina Arissa , Mendes Carolina Dusi , Corrêa Giovana Luiza , Mallmann Fernanda Emanuelle , Leitão Andressa Miguel 
Published: December 2022

Introdução: O Diabetes Mellitus Gestacional (DMG) é definido como qualquer grau de intolerância à glicose, com início ou primeiro reconhecimento durante a gestação que se resolve após o parto. A hiperglicemia durante o ciclo gravídico-puerperal é responsável pelo risco aumentado de desfechos perinatais indesejados e de complicações materno-fetais. A introdução de novos critérios pela International Association of Diabetes and Pregnancy Study Groups (IADPSG) visa melhorar tais desfechos a longo prazo. Objetivo: Analisar a incidência das complicações materno-fetais após o uso dos critérios da IADPSG para o diagnóstico de diabetes gestacional. Métodos: Trata-se de uma revisão integrativa de literatura, utilizando as bases de dados PUBMED e a Biblioteca Virtual em Saúde (BVS), que inclui as bases de dados MEDLINE, SciELO e LILACS. Os descritores aplicados foram “gestational diabetes”, “outcomes”, “incidence” e “IADPSG”, permutados pelo booleano “AND”. Foram selecionados os artigos publicados nos últimos 10 anos, totalizando 264 artigos. Ao final, 16 publicações foram selecionadas seguindo os critérios de elegibilidade. Resultados: Evidenciou-se o aumento da prevalência do diagnóstico de DMG com a aplicação do critério da IADPSG e redução da incidência da maioria das complicações maternas, fetais e perinatais. Provavelmente, tal resultado está associado com o tratamento dessas gestantes quando diagnosticadas precocemente com o critério da IADPSG. Apesar da discordância de resultados, grande parte dos autores apoia o uso das recomendações da IADPSG para o diagnóstico da DMG. Conclusão: A implementação dos critérios da IADPSG apresentou importante redução das complicações maternas e redução de algumas complicações fetais e perinatais analisadas no presente estudo. Assim, a utilização do critério IADPSG para avaliar a redução da incidência dos desfechos adversos maternos e fetais necessita de continuidade nas pesquisas a fim de determinar as vantagens do uso de tal critério quando comparado aos demais.
Connecting the Sustainable Development Goals to firm-level sustainability and ESG factors: The need for double materiality
Authors: Delgado-Ceballos Javier , Ortiz-De-Mandojana Natalia , Antolín-López Raquel , Montiel Ivan 
Published: December 2022

In this essay, we connect the United Nations’ Sustainable Development Goals (SDGs)—an extensive collection of society-level goals and targets aimed at addressing grand challenges and achieving global sustainability by 2030—to firm-level sustainability and Environmental, Social, and Governance (ESG) factors. In doing so, we highlight the importance of connecting the SDGs with the concept of double materiality—stakeholder materiality and financial materiality. Our assessment helps businesses navigate the intricate sustainability space and understand the ways in which their sustainability interventions can help solve the ESG grand challenges encapsulated in the SDGs. We conclude the article by introducing the five research articles that are part of the special issue “Our house is on fire! The role of business in achieving the Sustainable Development Goals” and suggesting a path for the future that revolves around creating standardized “sustainability balance sheets” in business. JEL CLASSIFICATION: M14, M20, Q50, Q56
Nelarabine combination therapy for relapsed or refractory T-cell acute lymphoblastic lymphoma/leukemia
Authors: Shimony Shai , Liu Yiwen , Valtis Yannis K. , Paolino Jonathan D. , Place Andrew E. , Brunner Andrew M. , Weeks Lachelle D. , Silverman Lewis B. , Vrooman Lynda M. , Neuberg Donna S. , Stone Richard M. , DeAngelo Daniel J. , Luskin Marlise R. 
Published: December 2022

Abstract
Nelarabine, an antimetabolite prodrug, is approved as monotherapy for children and adults with relapsed and refractory T-cell acute lymphoblastic leukemia and lymphoma (R/R T-ALL/LBL), although it is often used in combination regimens. We sought to understand differences in efficacy and toxicity when nelarabine is administered alone or in combination. We retrospectively analyzed 44 consecutive patients with R/R T-ALL/LBL; 29 of whom were treated with combination therapy, most with cyclophosphamide and etoposide (23, 79%) and 15 with monotherapy. The median age was 19 years (range, 2-69), including 18 children (&lt;18 years). After a median of 1 (range, 1-3) cycle of treatment, 24 patients (55%) achieved complete remission, 62% (18/29) with combination therapy and 40% (6/15) with monotherapy (P = .21). Most responders (21, 88%) pursued allogeneic stem cell transplant (alloSCT). Overall survival (OS) was 12.8 months (95% confidence interval, 6.93-not reached) in the entire cohort and was higher in the combination therapy than in the monotherapy group (24-month OS, 53% vs 8%; P = .003). The rate of neurotoxicity was similar between groups (27% vs 17%; P = .46) and grade 3/4 anemia and thrombocytopenia were more frequent in the combination group (76% vs 20%; P &lt; .001% and 66% vs 27%; P = .014, respectively). In a multivariate analysis, nelarabine combination therapy and alloSCT post nelarabine were associated with improved OS (hazard ratio, 0.41; P = .04 and hazard ratio, 0.25; P = .008, respectively). In conclusion, compared with monotherapy, nelarabine combination therapy was well tolerated and associated with improved survival in pediatric and adult patients with R/R T-ALL/LBL.
Characteristics of circulating KSHV-infected viroblasts during active KSHV+ multicentric Castleman disease
Authors: Martin de Frémont Gregoire , Vanjak Anthony , Sbihi Zineb , Knapp Silene , Garzaro Margaux , Chbihi Marwa , Fournier Benjamin , Poirot Justine , Dossier Antoine , Silvestrini Marc-Antoine , Villemonteix Juliette , Meignin Véronique , Galicier Lionel , Bertinchamp Rémi , Le Goff Jerome , Salmona Maud , Flamarion Edouard , Cassius Charles , Lebbé Celeste , Ronchetti Anne Marie , Latour Sylvain , Oksenhendler Eric , Carcelain Guislaine , Boutboul David 
Published: December 2022

Abstract
Kaposi sarcoma–associated herpesvirus (KSHV)/human herpesvirus 8–associated multicentric Castleman disease (MCD) is a polyclonal B-cell lymphoproliferative disorder that mainly occurs in immunocompromised hosts. The diagnosis relies on lymph node biopsy demonstrating KSHV-infected cells located in the mantle zone with a marked interfollicular plasma cell infiltration. Infected cells are large cells positive for immunoglobulin M (IgM), λ light chain, and CD38, described initially as infected plasmablasts. We show that IgM+λ+CD38high cells were also detectable in the peripheral blood of 14 out of 18 (78%) patients with active KSHV-MCD and absent in 40 controls. Using immunofluorescence and flow–fluorescence in situ hybridization, we demonstrate that these cells are KSHV infected and express both latent and lytic KSHV transcripts. These KSHV-infected viroblasts (KIVs) harbor a distinct phenotype compared with conventional plasmablasts. We also identified several putative mechanisms of immune escape used by KSHV, because KIVs displayed an overall decrease of costimulatory molecules, with a remarkable lack of CD40 expression and are interleukin-10–producing cells. The identification of this specific and easily accessible KSHV+ circulating population brings new elements to the understanding of KSHV-MCD but also raises new questions that need to be clarified.
Endoplasmic reticulum protein 5 attenuates platelet endoplasmic reticulum stress and secretion in a mouse model
Authors: Lay Angelina J. , Dupuy Alexander , Hagimola Lejla , Tieng Jessica , Larance Mark , Zhang Yunwei , Yang Jean , Kong Yvonne , Chiu Joyce , Gray Emilia , Qin Zihao , Schmidt Diana , Maclean Jessica , Hofma Benjamin , Ellis Marc , Kalev-Zylinska Maggie , Argon Yair , Jackson Shaun P. , Hogg Philip , Passam Freda H. 
Published: December 2022

Abstract
Extracellular protein disulfide isomerases (PDIs), including PDI, endoplasmic reticulum protein 57 (ERp57), ERp72, ERp46, and ERp5, are required for in vivo thrombus formation in mice. Platelets secrete PDIs upon activation, which regulate platelet aggregation. However, platelets secrete only ∼10% of their PDI content extracellularly. The intracellular role of PDIs in platelet function is unknown. Here, we aim to characterize the role of ERp5 (gene Pdia6) using platelet conditional knockout mice, platelet factor 4 (Pf4) Cre+/ERp5floxed (fl)/fl. Pf4Cre+/ERp5fl/fl mice developed mild macrothrombocytopenia. Platelets deficient in ERp5 showed marked dysregulation of their ER, indicated by a twofold upregulation of ER proteins, including PDI, ERp57, ERp72, ERp46, 78 kilodalton glucose-regulated protein (GRP78), and calreticulin. ERp5-deficient platelets showed an enhanced ER stress response to ex vivo and in vivo ER stress inducers, with enhanced phosphorylation of eukaryotic translation initiation factor 2A and inositol-requiring enzyme 1 (IRE1). ERp5 deficiency was associated with increased secretion of PDIs, an enhanced response to thromboxane A2 receptor activation, and increased thrombus formation in vivo. Our results support that ERp5 acts as a negative regulator of ER stress responses in platelets and highlight the importance of a disulfide isomerase in platelet ER homeostasis. The results also indicate a previously unanticipated role of platelet ER stress in platelet secretion and thrombosis. This may have important implications for the therapeutic applications of ER stress inhibitors in thrombosis.
Novel risk assessment for the intensity of conditioning regimen in older patients
Authors: Akahoshi Yu , Tada Yuma , Sakaida Emiko , Kusuda Machiko , Doki Noriko , Uchida Naoyuki , Fukuda Takahiro , Tanaka Masatsugu , Sawa Masashi , Katayama Yuta , Matsuoka Ken-ichi , Ozawa Yukiyasu , Onizuka Makoto , Kanda Junya , Kanda Yoshinobu , Atsuta Yoshiko , Nakasone Hideki 
Published: December 2022

Abstract
Reduced-intensity conditioning (RIC) regimens have long-term outcomes that are generally comparable with those of myeloablative conditioning (MAC) because of a lower risk of nonrelapse mortality (NRM) but a higher risk of relapse. However, it is unclear how we should select the conditioning intensity in individual cases. We propose the risk assessment for the intensity of conditioning regimen in elderly patients (RICE) score. We retrospectively analyzed 6147 recipients aged 50 to 69 years using a Japanese registry database. Based on the interaction analyses, advanced age (≥60 years), hematopoietic cell transplantation–specific comorbidity index (≥2), and umbilical cord blood were used to design a scoring system to predict the difference in an individual patient's risk of NRM between MAC and RIC: the RICE score, which is the sum of the 3 factors. Zero or 1 implies low RICE score and 2 or 3, high RICE score. In multivariate analyses, RIC was significantly associated with a decreased risk of NRM in patients with a high RICE score (training cohort: hazard ratio [HR], 0.73; 95% confidence interval [CI], 0.60-0.90; P = .003; validation cohort: HR, 0.57; 95% CI, 0.43-0.77; P &lt; .001). In contrast, we found no significant differences in NRM between MAC and RIC in patients with a low RICE score (training cohort: HR, 0.99; 95% CI, 0.85-1.15; P = .860; validation cohort: HR, 0.81; 95% CI, 0.66-1.01; P = .061). In summary, a new and simple scoring system, the RICE score, appears to be useful for personalizing the conditioning intensity and could improve transplant outcomes in older patients.
Novel Hybrid Physics-Informed Deep Neural Network for Dynamic Load Prediction of Electric Cable Shovel
Authors: Fu Tao , Zhang Tianci , Cui Yunhao , Song Xueguan 
Published: December 2022

AbstractElectric cable shovel (ECS) is a complex production equipment, which is widely utilized in open-pit mines. Rational valuations of load is the foundation for the development of intelligent or unmanned ECS, since it directly influences the planning of digging trajectories and energy consumption. Load prediction of ECS mainly consists of two types of methods: physics-based modeling and data-driven methods. The former approach is based on known physical laws, usually, it is necessarily approximations of reality due to incomplete knowledge of certain processes, which introduces bias. The latter captures features/patterns from data in an end-to-end manner without dwelling on domain expertise but requires a large amount of accurately labeled data to achieve generalization, which introduces variance. In addition, some parts of load are non-observable and latent, which cannot be measured from actual system sensing, so they can’t be predicted by data-driven methods. Herein, an innovative hybrid physics-informed deep neural network (HPINN) architecture, which combines physics-based models and data-driven methods to predict dynamic load of ECS, is presented. In the proposed framework, some parts of the theoretical model are incorporated, while capturing the difficult-to-model part by training a highly expressive approximator with data. Prior physics knowledge, such as Lagrangian mechanics and the conservation of energy, is considered extra constraints, and embedded in the overall loss function to enforce model training in a feasible solution space. The satisfactory performance of the proposed framework is verified through both synthetic and actual measurement dataset.
Comparison of adhesion of thawed and cultured synovial mesenchymal stem cells to the porcine meniscus and the relevance of cell surface microspikes
Authors: Fujii Shunichi , Endo Kentaro , Ozeki Nobutake , Sakamaki Yuriko , Kohno Yuji , Mizuno Mitsuru , Katano Hisako , Tsuji Kunikazu , Koga Hideyuki , Sekiya Ichiro 
Published: December 2022

Abstract
Background
Placement of a cultured synovial mesenchymal stem cell (MSC) suspension on a repaired meniscus for 10 min accelerated meniscus repair. Upon placement of the MSC suspension on the meniscus, microspikes projecting from the MSC surface trap meniscus fibers and promote MSC adhesion. Thawed cryopreserved MSCs are preferred materials for meniscus repair, as they can be transplanted without additional culture. However, the adhesion ability of thawed cryopreserved MSCs is unknown. Here, we compared the proportion of cultured versus thawed MSCs adhering to a porcine meniscus immediately and 10 min after placement. We also investigated the relationship between adhesion and the number of microspikes on the synovial MSCs.

Methods
Synovial MSCs were prepared from the knees of four donors with osteoarthritis. The “cultured MSCs” were thawed MSCs that were re-cultured and suspended in PBS for transplantation. A similarly prepared suspension was cryopreserved, thawed again, suspended in PBS, and used without further culture as the “thawed MSCs.” MSCs with at least three microspikes in SEM images were defined as microspike-positive MSCs. Porcine meniscus surfaces were abraded, cut into a cylindrical shape, and treated with MSC suspension. Non-adherent cells were counted immediately and again 10 min after placement to calculate the adhesion proportion.

Results
The proportion of microspike-positive MSCs was significantly higher in thawed (53 ± 3%) than in cultured (28 ± 5%) MSC suspensions. MSC adhesion to the meniscus was significantly better for the thawed than for the cultured MSC suspensions immediately after placement on the meniscus, but no differences were detected after 10 min. The proportion of MSCs with microspikes in the cell suspension was significantly correlated with the proportion of adhered MSCs immediately after the placement, but not 10 min later. Addition of FBS to the cryopreservation medium promoted a concentration-dependent increase in the proportion of microspike-positive cells.

Conclusions
Thawed MSCs adhered better than cultured MSCs immediately after placement, but adhesion was similar for both MSC preparations after 10 min. Immediately after placement, the presence of microspikes was associated with better adhesion of synovial MSCs to the meniscus.
Allopatric divergence of cooperators confers cheating resistance and limits effects of a defector mutation
Authors: Schaal Kaitlin A. , Yu Yuen-Tsu Nicco , Vasse Marie , Velicer Gregory J. 
Published: December 2022

Abstract
Background
Social defectors may meet diverse cooperators. Genotype-by-genotype interactions may constrain the ranges of cooperators upon which particular defectors can cheat, limiting cheater spread. Upon starvation, the soil bacterium Myxococcus xanthus cooperatively develops into spore-bearing fruiting bodies, using a complex regulatory network and several intercellular signals. Some strains (cheaters) are unable to sporulate effectively in pure culture due to mutations that reduce signal production but can exploit and outcompete cooperators within mixed groups.

Results
In this study, interactions between a cheater disrupted at the signaling gene csgA and allopatrically diversified cooperators reveal a very small cheating range. Expectedly, the cheater failed to cheat on all natural-isolate cooperators owing to non-cheater-specific antagonisms. Surprisingly, some lab-evolved cooperators had already exited the csgA mutant’s cheating range after accumulating fewer than 20 mutations and without experiencing cheating during evolution. Cooperators might also diversify in the potential for a mutation to reduce expression of a cooperative trait or generate a cheating phenotype. A new csgA mutation constructed in several highly diverged cooperators generated diverse sporulation phenotypes, ranging from a complete defect to no defect, indicating that genetic backgrounds can limit the set of genomes in which a mutation creates a defector.

Conclusions
Our results demonstrate that natural populations may feature geographic mosaics of cooperators that have diversified in their susceptibility to particular cheaters, limiting defectors’ cheating ranges and preventing them from spreading. This diversification may also lead to variation in the phenotypes generated by any given cooperation-gene mutation, further decreasing the chance of a cheater emerging which threatens the persistence of cooperation in the system.
Identification of metabolism-related genes for predicting peritoneal metastasis in patients with gastric cancer
Authors: Tian Chenyu , Zhao Junjie , Liu Dan , Sun Jie , Ji Chengbo , Jiang Quan , Li Haojie , Wang Xuefei , Sun Yihong 
Published: December 2022

Abstract
Objective
The reprogramming of metabolism is an important factor in the metastatic process of cancer. In our study, we intended to investigate the predictive value of metabolism-related genes (MRGs) in recurrent gastric cancer (GC) patients with peritoneal metastasis.

Methods
The sequencing data of mRNA of GC patients were obtained from Asian Cancer Research Group (ACRG) and the GEO databases (GSE53276). The differentially expressed MRGs (DE-MRGs) between a cell line without peritoneal metastasis (HSC60) and one with peritoneal metastasis (60As6) were analyzed with the Limma package. According to the LASSO regression, eight MRGs were identified as crucially related to peritoneal seeding recurrence in patients. Then, disease free survival related genes were screened using Cox regression, and a promising prognostic model was constructed based on 8 MRGs. We trained and verified it in two independent cohort.

Results
We confirmed 713 DE-MRGs and the enriched pathways. Pathway analysis found that the MRG-related pathways were related to tumor metabolism development. With the help of Kaplan–Meier analysis, we found that the group with higher risk scores had worse rates of peritoneal seeding recurrence than the group with lower scores in the cohorts.

Conclusions
This study developed an eight-gene signature correlated with metabolism that could predict peritoneal seeding recurrence for GC patients. This signature could be a promising prognostic model, providing better strategy in treatment.