bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Salicylic Acid Impacts on Physiological and Biochemical Characteristics under Water Deficit Stress on Pea (Pisum sativum L. var. Kashi Nandni)
Authors: Soni Pallavi , Nair Reena , Jain Surabhi , Sahu R. K. , Banjare Kunti , Sahu Karuna 
Published: October 2022

Aims: A study was conducted to investigate the effect of salicylic acid (SA) on garden pea grown under water deficit stress condition to discover the efficacy of foliar application of SA on physiological and biochemical characteristics of garden pea (Pisum sativum L.) cv. Kashi Nandni.
Study Design: With three replications, the experiment was performed in a split plot design.
Place and Duration of Study: Experiment was carried out in 2019-20 at Vegetable Research Centre, JNKVV, Jabalpur (M.P.), India.
Methodology: Main plots were assigned to irrigated and water deficit stress conditions, and subplots were associated to five dosages of SA (0, 0.25, 0.50, 0.75, and 1 mM). During flowering stage, relative water content (RWC) of leaves, light transmission ratio (LTR), energy interception (EI) were recorded and total soluble solids (TSS) was detected at the time of harvest.
Results: Finding of the research revealed that water deficit stress condition reduces the growth potential of plant via effecting the physiological and biochemical process of plant. The best drought protection was observed when the plant sprayed with 0.50 mM SA in RWC, light transmission %, energy interception and TSS content of garden pea. The analysis of variance shows that the effect of salicylic acid on all characteristics was significant.
Conclusion: According to the findings of this study, water deficit stress causes severe physiological and biochemical malfunctions in plants, resulting in a significant reduction in plant performance. Exogenous application of SA and its derivatives against abiotic stress has the potential to be very useful in agriculture and horticulture.
Health-Related Quality of Life Assessment in Post-Covid Patients: A Cross-Sectional Online Survey
Authors: Muppa Leena , Manikandan S. , Nissi L. , Arasi A. Tamil , Yamini J. 
Published: October 2022

Aims:

To compare the impact of covid-19 infection and its associated factors among various domains of quality of life (general health (GH), physical health (PH), mental health, and pain).
To determine the variation and it’s contributing factors to the quality of life (QoL).
To identify the most common persisting symptoms after covid-19 infection.

Study Design: Cross-sectional community based online survey.
Place and Duration of Study: Community-based online survey done for a period of 6 months (March 2021- September 2021) among patients who recovered from covid-19.
Methodology: A validated self-made questionnaire with informed consent was used to gather information on the patient’s demographics (age, gender, educational qualification, occupation, marital status, and risk factors) covid-19 details (vaccination, severity, and hospitalization details), persisting symptoms, andHealth Related Quality of Life (HRQoL).
The HRQoL questions with scored options were framed under four domains general health, physical health, mental health, and pain. A convenient sample of 120 participants was included in our study.
Results: The median and inter-quartile ranges were used to describe the HRQoL score. For normal data, Multiple Linear Regression (MLR) was used to investigate the relationship between the dependent and independent variables.MLR results demonstrated that risk factors, severity, and length of hospital stay were negatively associated with QoL.
For non-normal data, the Kruskal Wallis test (KWT) and Mann Whitney U (MWU) test were used to compare the effect of covid-19 and its associated factors among various domains of HRQoL. KWT and MWT showed that the ability to perform physical activity was highly impaired in most post-covid patients. Cough, myalgia, arthralgia, and headache were the significant persisting symptoms of covid-19, reported by our participants. IBM SPSS software version 28.0 was used for statistical analysis.
Conclusion: We conclude that health care intervention is needed to manage persisting symptoms and to improve HRQoL.
Motivation and Awareness of Female Physiotherapists in Saudi Arabia toward Women Health Physiotherapy
Authors: Al-Khalifa Shurouq Mohammed , Alotaibi Azizah Saad , Alamrah Shadin Ali , Al-Badr Ahmad , Fallatah Bashaer Adel , Mahroos Rabya Adel , Alali Maram Mohammed 
Published: October 2022

Background: Pelvic floor disorders (PFDs) are a group of common conditions that create a great distress to the lives of many female patients. The role of women health physiotherapy (WHPT) in managing PFDs is crucial. Scarce data in the literature describe the awareness, attitude, and practice of WHPT among female physiotherapists and to the best of our knowledge, none are reported in Saudi Arabia. This paper hypothesizes that female physiotherapists in Saudi Arabia are less motivated to practice WHPT and that being less motivated have led to acquiring a lower level of awareness to the specialty. Additionally, it aims to explore the beliefs of female physiotherapists toward WHPT.
Methods: An online questionnaire was distributed among female physiotherapists working in Saudi Arabia. Participants were asked to identify other colleagues to include in the sample. Reliability of the questionnaire was tested using a pilot study.
Results: The majority of respondents [75.9%] are specialists and 69.2% reported years of experience ranging from 1 to 5. Around 46.9% of respondents were motivated to practice WHPT and 82.1% agreed that physiotherapy is important in treating PFDs. Additionally, Respondents who were motivated to practice WHPT displayed a significantly higher level of awareness to the specialty and understood the importance of pelvic floor rehabilitation (PFR) as an intervention for PFDs.
Conclusions: There is adequate level of awareness of female physiotherapists in Saudi Arabia to WHPT and a great motivation to practice the specialty. The study highlighted the need to organize various educational programs and workshops that focus on WHPT and PFR.
Screening for Anxiety in Children and Adolescents
Authors: Viswanathan Meera , Wallace Ina F. , Cook Middleton Jennifer , Kennedy Sara M. , McKeeman Joni , Hudson Kesha , Rains Caroline , Vander Schaaf Emily B. , Kahwati Leila 
Published: October 2022

ImportanceAnxiety in children and adolescents is associated with impaired functioning, educational underachievement, and future mental health conditions.ObjectiveTo review the evidence on screening for anxiety in children and adolescents to inform the US Preventive Services Task Force.Data SourcesPubMed, Cochrane Library, PsycINFO, CINAHL, and trial registries through July 19, 2021; references, experts, and surveillance through June 1, 2022.Study SelectionEnglish-language, randomized clinical trials (RCTs) of screening; diagnostic test accuracy studies; RCTs of cognitive behavioral therapy (CBT) or US Food and Drug Administration–approved pharmacotherapy; RCTs, observational studies, and systematic reviews reporting harms.Data Extraction and SynthesisTwo reviewers assessed titles/abstracts, full-text articles, and study quality and extracted data; when at least 3 similar studies were available, meta-analyses were conducted.Main Outcomes and MeasuresTest accuracy, symptoms, response, remission, loss of diagnosis, all-cause mortality, functioning, suicide-related symptoms or events, adverse events.ResultsThirty-nine studies (N = 6065) were included. No study reported on the direct benefits or harms of screening on health outcomes. Ten studies (n = 3260) reported the sensitivity of screening instruments, ranging from 0.34 to 1.00, with specificity ranging from 0.47 to 0.99. Twenty-nine RCTs (n = 2805) reported on treatment: 22 on CBT, 6 on pharmacotherapy, and 1 on CBT, sertraline, and CBT plus sertraline. CBT was associated with gains on several pooled measures of symptom improvement (magnitude of change varied by outcome measure), response (pooled relative risk [RR], 1.89 [95% CI, 1.17 to 3.05]; n = 606; 6 studies), remission (RR, 2.68 [95% CI, 1.48 to 4.88]; n = 321; 4 studies), and loss of diagnosis (RR range, 3.02-3.09) when compared with usual care or wait-list controls. The evidence on functioning for CBT was mixed. Pharmacotherapy, when compared with placebo, was associated with gains on 2 pooled measures of symptom improvement—mean difference (Pediatric Anxiety Rating Scale mean difference, −4.0 [95% CI, −5.5 to −2.5]; n = 726; 5 studies; and Clinical Global Impression–Severity scale mean difference, −0.84 [95% CI, −1.13 to −0.55]; n = 550; 4 studies) and response (RR, 2.11 [95% CI, 1.58 to 2.98]; n = 370; 5 studies)—but was mixed on measures of functioning. Eleven RCTs (n = 1293) reported harms of anxiety treatments. Suicide-related harms were rare, and the differences were not statistically significantly different.Conclusions and RelevanceIndirect evidence suggested that some screening instruments were reasonably accurate. CBT and pharmacotherapy were associated with benefits; no statistically significant association with harms was reported.
Screening for Anxiety in Children and Adolescents
Authors:   US Preventive Services Task Force, Mangione Carol M. , Barry Michael J. , Nicholson Wanda K. , Cabana Michael , Coker Tumaini Rucker , Davidson Karina W. , Davis Esa M. , Donahue Katrina E. , Jaén Carlos Roberto , Kubik Martha , Li Li , Ogedegbe Gbenga , Pbert Lori , Ruiz John M. , Silverstein Michael , Stevermer James , Wong John B. 
Published: October 2022

ImportanceAnxiety disorder, a common mental health condition in the US, comprises a group of related conditions characterized by excessive fear or worry that present as emotional and physical symptoms. The 2018-2019 National Survey of Children’s Health found that 7.8% of children and adolescents aged 3 to 17 years had a current anxiety disorder. Anxiety disorders in childhood and adolescence are associated with an increased likelihood of a future anxiety disorder or depression.ObjectiveThe US Preventive Services Task Force (USPSTF) commissioned a systematic review to evaluate the benefits and harms of screening for anxiety disorders in children and adolescents. This is a new recommendation.PopulationChildren and adolescents 18 years or younger who do not have a diagnosed anxiety disorder or are not showing recognized signs or symptoms of anxiety.Evidence AssessmentThe USPSTF concludes with moderate certainty that screening for anxiety in children and adolescents aged 8 to 18 years has a moderate net benefit. The USPSTF concludes that the evidence is insufficient on screening for anxiety in children 7 years or younger.RecommendationThe USPSTF recommends screening for anxiety in children and adolescents aged 8 to 18 years. (B recommendation) The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for anxiety in children 7 years or younger. (I statement)
Association of Sodium-Glucose Cotransporter-2 Inhibitors With Incident Atrial Fibrillation in Older Adults With Type 2 Diabetes
Authors: Zhuo Min , D’Andrea Elvira , Paik Julie M. , Wexler Deborah J. , Everett Brendan M. , Glynn Robert J. , Kim Seoyoung C. , Patorno Elisabetta 
Published: October 2022

ImportanceSodium-glucose cotransporter-2 inhibitors (SGLT-2is) have demonstrated many cardiovascular and kidney function benefits for patients with type 2 diabetes (T2D). However, the results of SGLT-2i use in primary prevention of atrial fibrillation (AF) were inconsistent in clinical trials, and incident AF was not a prespecified end point.ObjectiveTo examine incident AF with initiation of an SGLT-2i compared with initiation of a dipeptidyl peptidase-4 inhibitor (DPP-4i) or a glucagonlike peptide-1 receptor agonist (GLP-1RA) among older adults (aged ≥66 years) with T2D in routine clinical practice.Design, Setting, and ParticipantsA population-based new-user cohort study included older adults with T2D who had no history of AF and were enrolled in Medicare fee-for-service from April 1, 2013, to December 31, 2018. Data analysis was performed from June 28 to December 1, 2021.ExposuresTo control for potential confounding, new users of SGLT-2i were 1:1 propensity score (PS)–matched to new users of DPP-4is or GLP-1RAs in 2 pairwise comparisons based on 138 baseline covariates.Main Outcomes and MeasuresThe primary outcome was incident AF, defined as an inpatient diagnosis code for AF. Hazard ratios (HRs) and rate differences (RDs) per 1000 person-years, with their 95% CIs, were estimated in the PS-matched groups.ResultsNew users of SGLT-2is were 1:1 PS-matched to new users of a DPP-4i (n = 74 868) or GLP-1RA (n = 80 475). Overall, the mean (SD) age of study participants was 72 (5) years, and 165 984 were women (53.4%). The risk of incident AF was lower in the SGLT-2i group than the matched DPP-4i group (HR, 0.82; 95% CI, 0.76 to 0.89; RD, –3.7; 95% CI, –5.2 to –2.2 per 1000 person-years) or the matched GLP-1RA group (HR, 0.90; 95% CI, 0.83 to 0.98; RD, –1.8; 95% CI, –3.2 to –0.3 per 1000 person-years). Results were consistent across several sensitivity and subgroup analyses.Conclusions and RelevanceThe findings of this study suggest that the initiation of an SGLT-2i was associated with a reduced risk of incident AF compared with a DPP-4i or GLP-1RA. The results may be helpful when weighing the potential risks and benefits of various glucose level–lowering agents in older adults with T2D.
Predicting the disease severity in male individuals with ornithine transcarbamylase deficiency
Authors: Scharre Svenja , Posset Roland , Garbade Sven F. , Gleich Florian , Seidl Marie J. , Druck Ann‐Catrin , Okun Jürgen G. , Gropman Andrea L. , Nagamani Sandesh C. S. , Hoffmann Georg F. , Kölker Stefan , Zielonka Matthias ,   for the Urea Cycle Disorders Consortium (UCDC) and the European registry and network for Intoxication type Metabolic Diseases (E‐IMD) Consortia Study Group
Published: October 2022

AbstractObjectiveOrnithine transcarbamylase deficiency (OTC‐D) is an X‐linked metabolic disease and the most common urea cycle disorder. Due to high phenotypic heterogeneity, ranging from lethal neonatal hyperammonemic events to moderate symptoms and even asymptomatic individuals, the prediction of the disease course at an early disease stage is very important to individually adjust therapies such as medical treatment or liver transplantation. In this translational study, we developed a severity‐adjusted classification system based on in vitro residual enzymatic OTC activity.MethodsApplying a cell‐based expression system, residual enzymatic OTC activities of 71 pathogenic OTC variants were spectrophotometrically determined and subsequently correlated with clinical and biochemical outcome parameters of 119 male individuals with OTC‐D (mOTC‐D) as reported in the UCDC and E‐IMD registries.ResultsIntegration of multiple data sources enabled the establishment of a robust disease prediction model for mOTC‐D. Residual enzymatic OTC activity not only correlates with age at first symptoms, initial peak plasma ammonium concentration and frequency of metabolic decompensations but also predicts mortality. The critical threshold of 4.3% residual enzymatic activity distinguishes a severe from an attenuated phenotype.InterpretationResidual enzymatic OTC activity reliably predicts the disease severity in mOTC‐D and could thus serve as a tool for severity‐adjusted evaluation of therapeutic strategies and counselling patients and parents.
Assessment of the Systemic Sclerosis–Associated Raynaud's Phenomenon Questionnaire: Item Bank and Short‐Form Development
Authors: Yu Lan , Domsic Robyn T. , Saketkoo Lesley‐Ann , Withey Jane , Frech Tracy M. , Herrick Ariane L. , Hummers Laura K. , Shah Ami A. , Denton Christopher P. , Khanna Dinesh , Pauling John D. 
Published: October 2022

ObjectiveTo develop, refine, and score a novel patient‐reported outcome instrument to assess the severity and impact of Raynaud's phenomenon (RP) in systemic sclerosis (SSc).MethodsThe Assessment of Systemic Sclerosis–Associated Raynaud's Phenomenon (ASRAP) questionnaire items were developed with patient insight partner support and grounded in the lived patient experience of SSc‐RP. ASRAP items underwent formal qualitative assessment and linguistic testing. An international multicenter study was undertaken to field test the preliminary ASRAP questionnaire.ResultsA preliminary 37‐item ASRAP questionnaire was supplemented with 2 additional items following expert review to enhance content coverage before undergoing formal linguistic testing to optimize readability. Patient cognitive debriefing interviews were undertaken to enhance comprehension, ambiguity, cognitive difficulty, relevance, and content coverage of both the ASRAP items and instructions. We enrolled 420 SSc patients from scleroderma centers in the UK and US over 2 consecutive winters. Factor analysis with item response theory was undertaken to remove redundant and poorly fitting items. The retained 27‐item long‐form ASRAP questionnaire was calibrated and scored using the graded response model. A fixed 10‐item short‐form ASRAP questionnaire was developed using computerized adaptive testing simulations.ConclusionThe ASRAP questionnaire has been developed with extensive SSc patient input, with items grounded in the lived experience of SSc‐RP to ensure strong content validity, with a focus on how patients feel and function. An advanced psychometric approach with expert input has removed redundant and/or poorly fitting items without eroding content validity. Long‐ and short‐form ASRAP questionnaires have been calibrated and scored to permit formal validation.
Targeted Self‐assembly of Renal Clearable Cu2‐xSe to Induce Lysosome Swelling for Multimodal Imaging Guided Photothermal/Chemodynamic Synergistic Therapy
Authors: Luan Xiaowei , Pan Yongchun , Zhou Yuyu , Zhou Dongtao , Zhao Wenjian , Zeng Fei , Zhu Zhenxing , Lu Qiangbing , Lu Qianglan , Gao Yanfeng , He Guanzhong , Lu Minghui , Song Yujun 
Published: October 2022

AbstractRenal clearance is critical for nanodrug to avoid the long‐term body retention‐related side effects, while it is difficult to achieve efficient tumor accumulation and retention. The over‐developed lysosomes in cancer cells have become an emerging target for more precise and effective cancer therapy. Herein, a pH‐responsive reversible self‐assembled Cu2‐xSe‐BSA, which can be renal cleared under neutral or basic conditions, is developed for selectively targeted aggregation in cancer lysosomes with enhanced tumor accumulation and retention. Moreover, the aggregation of Cu2‐xSe‐BSA can enhance the photoacoustic imaging signal, photothermal therapy, and chemodynamic therapy capability. Cu2‐xSe‐BSA accumulated in lysosomes cannot only induce lysosomes swelling, but also generate reactive oxygen species in situ, causing lysosomal membrane permeabilization and finally lysosomal cell death. Notably, the assembled Cu2‐xSe‐BSA can dissociate to be renal clearable after the treatments are completed and left the acid tumor microenvironment, being of great significance both in scientific research and clinical trial.
Binary Metal Single Atom Electrocatalysts with Synergistic Catalytic Activity toward High‐Rate and High Areal‐Capacity Lithium–Sulfur Batteries
Authors: Ma Lianbo , Qian Ji , Li Yongtao , Cheng Yuwen , Wang Shanying , Wang Ziwei , Peng Cheng , Wu Konglin , Xu Jie , Manke Ingo , Yang Chao , Adelhelm Philipp , Chen Renjie 
Published: October 2022

AbstractLithium–sulfur (Li–S) batteries with high theoretical energy density have been long considered as an alternative energy storage device to lithium‐ion batteries. Nevertheless, the polysulfide shuttle effects trigger fast capacity decay and short battery lifespan, severely hampering their practical utilizations. Herein, an efficient electrocatalyst comprising of nitrogen (N)‐coordinated binary metal single atoms (SAs) implanted within a hierarchical porous carbon skeleton (Fe/CoNHPC) is constructed to trap and catalyze polysulfides conversion through a separator coating strategy. It is demonstrated that the introduction of Co atom can enrich the electron number of Fe active center, thereby realizing the distinct synergistic catalytic effect of binary metal SAs and improving the bidirectional catalysis of Li–S redox reaction. As a result, Li–S batteries with the Fe/CoNHPC‐modified separator exhibit outstanding rate capability (740 mAh g−1 at 5.0 C), and superior long‐term cyclic stability (694 mAh g−1 after 600 cycles at 1.0 C). Increasing the sulfur loading to 4.8 mg cm−2, a remarkable areal capacity of 6.13 mAh cm−2 is achieved. Furthermore, in situ X‐ray diffraction and theoretical simulation results verify the catalysis mechanism of binary metal SAs by changing the rate‐determining steps, providing new directions for constructing high‐performance Li–S batteries.
Bush‐Shaped Vertical Graphene/Nichrome Wire for Blackbody‐Like Radiative Heating
Authors: Wang Kun , Cheng Shuting , Yang Jiawei , Cheng Yi , Ci Qing , Yuan Hao , Huang Kewen , Liu Ruojuan , Li Wenjuan , Li Junliang , Tu Ce , Liang Fushun , Yang Yuyao , Sun Jianbo , Hu Qingmei , Yin Jianbo , Guan Baolu , Ren Xingang , Qi Yue , Liu Zhongfan 
Published: October 2022

AbstractRadiative thermal management has attracted increasing attention for the advantages of energy saving and carbon emission reduction. Infrared radiation coatings are widely adopted to alleviate the low infrared emissivity of commonly used metal alloy electrothermal materials. However, traditional infrared radiation coatings are faced with the issues of the unsteady waveband emissivity, low interfacial adhesion to substrates, and poor long‐term thermal stability. Herein, a bush‐shaped vertical graphene (BVG) grown on nichrome (Ni–Cr) wire is demonstrated, relying on which BVG/Ni–Cr wire presents a high blackbody‐like emissivity of ≈0.96 across a wide wavelength range (2.5–18 µm). When used for radiative heating, BVG/Ni–Cr wire achieves a high thermal radiation efficiency with an order of magnitude improvement compared with bare Ni–Cr wire, as well as the superior deformation and thermal stabilities. These findings reveal the impressive potentials of BVG as an excellent infrared radiation material for the energy‐efficient radiative thermal management.
Fine‐Tuning Cu (II)‐Induced Self‐Assembly of Hydrophilic Cyanine Dyes for Enhanced Tumor Photothermal Therapy
Authors: Feng Erting , Liu Yuhan , Lv Shibo , Liu Dapeng , Huang Shuheng , Li Zhiliang , Song Fengling 
Published: October 2022

AbstractSupramolecular self‐assembly of near‐infrared (NIR) dyes are believed to be a promising strategy to design effective photothermal agents for tumor photothermal therapy (PTT). However, due to the uncontrollable intermolecular interactions, accurately fine‐tuning the aggregated morphology of NIR dyes through adjusting their supramolecular self‐assembly is challenging. Here, based on organic–metal coordination interaction, a facile self‐assembly fine‐tuning strategy is proposed to adjust the aggregated morphology of heptamethine cyanine (Cy7) dyes, the well‐known NIR dyes. Three hydrophilic Cy7 derivatives Cy‐nCOOH (n = 1, 2, and 3) are synthesized, and then are coordinated with Cu2+to obtain different aggregates. Cy‐1COOH/Cu aggregates form partial J‐aggregates. Cy‐2COOH/Cu aggregates are amorphous. Noteworthily, Cy‐3COOH/Cu aggregates exhibit significant H‐type aggregation. Moreover, Cy‐3COOH/Cu aggregates show about threefold higher photothermal conversion efficiency and obviously enhanced photostability than Cy‐1COOH/Cu and Cy‐2COOH/Cu aggregates. It is demonstrated that H‐aggregates with face‐to‐face π–π stacking greatly quench fluorescence and inhibit singlet oxygen (1O2) production, which lead to the improved photothermal performances. In vitro and in vivo experiments demonstrate the remarkable tumor PTT efficiency of Cy‐3COOH/Cu H‐aggregates. This study provides a new insight into how to precisely control molecular aggregation of organic dyes in supramolecular self‐assembly for enhanced tumor phototherapy.