bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using thermal UAV imagery to model distributed debris thicknesses and sub-debris melt rates on debris-covered glaciers
Authors: Bisset Rosie R. , Nienow Peter W. , Goldberg Daniel N. , Wigmore Oliver , Loayza-Muro Raúl A. , Wadham Jemma L. , Macdonald Moya L. , Bingham Robert G. 
Published: December 2022

AbstractSupraglacial debris cover regulates the melt rates of many glaciers in mountainous regions around the world, thereby modifying the availability and quality of downstream water resources. However, the influence of supraglacial debris is often poorly represented within glaciological models, due to the absence of a technique to provide high-precision, spatially continuous measurements of debris thickness. Here, we use high-resolution UAV-derived thermal imagery, in conjunction with local meteorological data, visible UAV imagery and vertically profiled debris temperature time series, to model the spatially distributed debris thickness across a portion of Llaca Glacier in the Cordillera Blanca of Peru. Based on our results, we simulate daily sub-debris melt rates over a 3-month period during 2019. We demonstrate that, by effectively calibrating the radiometric thermal imagery and accounting for temporal and spatial variations in meteorological variables during UAV surveys, thermal UAV data can be used to more precisely represent the highly heterogeneous patterns of debris thickness and sub-debris melt on debris-covered glaciers. Additionally, our results indicate a mean sub-debris melt rate nearly three times greater than the mean melt rate simulated from satellite-derived debris thicknesses, emphasising the importance of acquiring further high-precision debris thickness data for the purposes of investigating glacier-scale melt processes, calibrating regional melt models and improving the accuracy of runoff predictions.
Witness statements and the technologies of memory: A conversation between Heba Y. Amin, Anthony Downey, Helene Kazan, Naeem Mohaiemen, and Susan Schuppli
Authors: Amin Heba Y. , Downey Anthony , Kazan Helene , Mohaiemen Naeem , Schuppli Susan 
Published: December 2022

Abstract
Bringing together artistic and scientific modes of inquiry, Witness statements and the technologies of memory examines the impact that digital technologies have on the substance of truth and historical facts. Hosted as part of Heba Y. Amin and Anthony Downey's online symposium, which was held in conjunction with Amin's exhibition When I see the future, I close my eyes, Chapter I (curated by Downey for the Mosaic Rooms in 2020), the panel discussed the legacies of colonial power and command, regimes of memory, and the ex post facto constitution of evidence from online archives. Drawing upon the diverse backgrounds and experiences of the panellists, which included Helene Kazan (Oxford Brookes University), Naeem Mohaiemen (Columbia University), and Susan Schuppli (Goldsmiths, University of London), Heba Y. Amin (Staatliche Akademie der Bildenden Künste Stuttgart), and Anthony Downey (Birmingham City University), Witness statements and the technologies of memory sought to more fully understand the impact of digital archives on historical records and evidence-gathering. Against the backdrop of indiscriminate expurgations of online material, we observe how the evidentiary potential of digital archives is compromised by the commercial imperatives of social media networks, censorship, and state surveillance. Among the many questions that arise here, the extent to which personal recollections are often presented as virtual artefacts of memory – a technology of recall or a mnemo-technics in its own right – remains central to the debate about the future of memory in our post-digital age.
IPBES as a transformative agent: opportunities and risks
Authors: Gustafsson Karin M , Hysing Erik 
Published: December 2022

SummaryThe Intergovernmental Science–Policy Platform for Biodiversity and Ecosystem Services (IPBES) has played an important role in assessing knowledge and raising awareness of biodiversity loss, and it is now also mandated to assess and support processes of transformative change. This perspective paper argues that the transformative change assessment entails key elements of transformative agency, which, along with the performative role of IPBES, makes it relevant to re-conceptualize the organization as a transformative agent. This new role will change IPBES and brings attention to risks related to undermining the credibility, relevance and legitimacy of IPBES, but it also brings opportunities for innovations that may strengthen the organization, including furthering public reasoning, acknowledging ambiguities and disagreements, ensuring scientific autonomy and balancing governmental power in the organization. As IPBES takes on the fundamental challenge of transformative change, critical scrutiny and democratic debate regarding its function as a political actor are more important than ever.
Efficacy of Video Laryngoscopy versus Direct Laryngoscopy in the Prehospital Setting: A Systematic Review and Meta-Analysis
Authors: Pourmand Ali , Terrebonne Emily , Gerber Stephen , Shipley Jeffrey , Tran Quincy K. 
Published: December 2022

AbstractIntroduction:Placing an endotracheal tube is a life-saving measure. Direct laryngoscopy (DL) is traditionally the default method. Video laryngoscopy (VL) has been shown to improve efficiency, but there is insufficient evidence comparing VL versus DL in the prehospital settings. This study, comprising a systematic review and random-effects meta-analysis, assesses current literature for the efficacy of VL in prehospital settings.Methods:PubMed and Scopus databases were searched from their beginnings through March 1, 2022 for eligible studies. Outcomes were the ﬁrst successful intubation, overall success rate, and number of total DL versus VL attempts in real-life clinical situations. Cochrane’s Risk of Bias (RoB) tool and the Newcastle-Ottawa Scale (NOS) were applied to assess risk of bias and study quality; Q-statistics and I2 values were used to assess heterogeneity.Results:The search yielded seven studies involving 23,953 patients, 6,674 (28%) of whom underwent intubation via VL. Compared to DL, VL was associated with a statistically higher risk ratio for first-pass success (Risk Ratio [RR] = 1.116; 95% CI, 1.005-1.239; P = .041; I2 = 87%). The I2 value for the subgroup of prospective studies was 0% compared to 89% for retrospective studies. In addition, VL was associated with higher likelihood of overall success rate (RR = 1.097; 95% CI, 1.01-1.18; P = .021; I2 = 85%) and lower mean number of attempts (Mean Difference = -0.529; 95% CI, -0.922 to -0.137; P = .008).Conclusion:The meta-analysis suggested that VL was associated with higher likelihood of achieving first-pass success, greater overall success rate, and lower number of intubation attempts for adults in the prehospital settings. This study had high heterogeneity, likely presenced by the inclusion of retrospective observational studies. Further studies with more rigorous methodology are needed to confirm these results.
Longitudinal post-shunt outcomes in idiopathic normal pressure hydrocephalus with and without comorbid Alzheimer’s disease
Authors: Gold Dov , Wisialowski Caroline , Piryatinsky Irene , Malloy Paul , Correia Stephen , Salloway Stephen , Klinge Petra , Gaudet Charles E. , Niermeyer Madison , Lee Athene 
Published: December 2022

AbstractObjective:Alzheimer’s disease (AD) is highly comorbid with idiopathic normal pressure hydrocephalus (iNPH) and may diminish the benefits of shunting; however, findings in this area are mixed. We examined postoperative outcomes, with emphases on cognition and utilization of novel scoring procedures to enhance sensitivity.Methods:Using participant data from an iNPH outcome study at Butler Hospital, a mixed effect model examined main and interaction effects of time since surgery (baseline, 3 months, 12 months, and 24–60 months) and AD comorbidity (20 iNPH and 11 iNPH+AD) on activities of daily living (ADLs) and iNPH symptoms. Regression modeling explored whether baseline variables predicted improvements 3 months postoperatively.Results:There were no group differences in gait, incontinence, and global cognition over time, and neither group showed changes in ADLs. Cognitive differences were observed postoperatively; iNPH patients showed stable improvements in working memory (p = 0.012) and response inhibition (p = 0.010), while iNPH + AD patients failed to maintain initial gains. Regarding predicting postoperative outcomes, baseline AD biomarkers did not predict shunt response at 3 months; however, older age at surgery predicted poorer cognitive outcomes (p = 0.04), and presurgical Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) (p = 0.035) and Mini-Mental Status Examination (MMSE) scores (p = 0.009) predicted improvements incontinence.Conclusion:iNPH + AD may be linked with greater declines in aspects of executive functioning postoperatively relative to iNPH alone. While baseline AD pathology may not prognosticate shunt response, younger age appears linked with postsurgical cognitive improvement, and utilizing both brief and comprehensive cognitive measures may help predict improved incontinence. These results illustrate the potential benefits of surgery and inform postoperative expectations for those with iNPH + AD.
Non‐Steady‐State 14C‐10Be and Transient Hillslope Dynamics in Steep High Mountain Catchments
Authors: Slosson John R. , Hoke Gregory D. , Lifton Nathaniel 
Published: December 2022

AbstractPaired in situ cosmogenic nuclides 14C and 10Be present an opportunity to explore erosion rate disequilibria over Holocene to latest Pleistocene timescales and are a new avenue in surface processes research. 14C and 10Be concentrations in quartz from river sand collected at the outlets of five mountainous catchments in the Argentine Andes are compared in this study. River gauge and 10Be‐derived erosion rates are in good agreement; however, 14C concentrations are approximately 2.7–4 times lower than expected relative to 10Be under steady‐state erosion. Low 14C to 10Be ratios imply that sediment eroded from the high mountains was shielded for at least 7–15 ky. Neoglacial advances and storage in terraces may account for some of the reduced 14C concentrations but are insufficient alone. Transient storage in dynamic talus slopes in the steep topography of the High Andes provides the best explanation for the observed 14C concentrations.
S1222a—The Largest Marsquake Detected by InSight
Authors: Kawamura Taichi , Clinton John F. , Zenhäusern Géraldine , Ceylan Savas , Horleston Anna C. , Dahmen Nikolaj L. , Duran Cecilia , Kim Doyeon , Plasman Matthieu , Stähler Simon C. , Euchner Fabian , Charalambous Constantinos , Giardini Domenico , Davis Paul , Sainton Grégory , Lognonné Philippe , Panning Mark , Banerdt William B. 
Published: December 2022

AbstractNASA's InSight has detected a large magnitude seismic event, labeled S1222a. The event has a moment magnitude of 4.7, with five times more seismic moment compared to the second largest event. The event is so large that features are clearly observed that were not seen in any previously detected events. In addition to body phases and Rayleigh waves, we also see Love waves, minor arc surface wave overtones, and multi‐orbit surface waves. At long periods, the coda event exceeds 10 hr. The event locates close to the North‐South dichotomy and outside the tectonically active Cerberus Fossae region. S1222a does not show any evident geological or tectonic features. The event is extremely rich in frequency content, extending from below 1/30 Hz up to 35 Hz. The event was classified as a broadband type event; we also observe coda decay and polarization similar to that of very high frequency type events.
IDO-1 inhibitor INCB24360 elicits distant metastasis of basal extruded cancer cells in pancreatic ductal adenocarcinoma
Authors: Buhe Hada , Ma Ji-xin , Ye Fang-zhou , Song Chen-yun , Chen Xin-yu , Liu Yang , Lin Huang , Han Xu , Ma Li-xiang , Saiyin Hexige 
Published: December 2022

AbstractNeoplastic cells of non-immunogenic pancreatic ductal adenocarcinoma (PDAC) express indoleamine 2,3-dioxygenase 1 (IDO-1), an immunosuppressive enzyme. The metabolites of IDO-1 in cancers provide one-carbon units that annihilate effector T cells, and recruit immunosuppressive cells. In this study we investigated how IDO-1 affected the neoplastic cell behaviors in PDACs. Using multiple markers co-labeling method in 45-µm-thick tissue sections, we showed that IDO-1 expression was uniquely increased in the neoplastic cells extruded from ducts’ apical or basal domain, but decreased in lymph metastatic cells. IDO-1+ extruding neoplastic cells displayed increased vimentin expression and decreased cytokeratin expression in PDACs, characteristics of epithelial-mesenchymal transition (EMT). However, IDO-1 expression was uncorrelated with immunosuppressive infiltrates and clinicopathological characteristics of grim outcome. We replicated basal extrusion with EMT in murine KPIC PDAC organoids by long-term IFN-γ induction; application of IDO-1 inhibitor INCB24360 or 1-MT partially reversed basal extrusion coupled EMT. Ido-1 deletion in KPIC cells deprived its tumorigenicity in immunocompetent mice, decreased cellular proliferation and macropinocytic ability, and increased immunogenicity. KPIC organoids with IFN-γ-induced basal extrusion did not accelerate distant metastasis, whereas inhibition IFN-γ-induced IDO-1 with INB24360 but not 1-MT in KPIC organoids elicited liver metastasis of subcutaneous KPIC organoid tumors, suggesting that lower IDO-1 activity accelerated distant metastasis, whereas IDO-1 was indispensable for tumorigenicity of PDAC cells and supports the survival of extruding cells.
Activation of ALOX12 by a multi-organelle-orienting photosensitizer drives ACSL4-independent cell ferroptosis
Authors: Wang Xiuxia , Chen Yuanhong , Yang Xiang , Cheng Lianghui , He Zhenyan , Xin Yanru , Huang Shan , Meng Fanling , Zhang Peijing , Luo Liang 
Published: December 2022

AbstractFerroptosis is a recently-defined tumor suppression mechanism, but the sensitivity of many tumorigenic cells to ferroptosis is limited by their deficient expression of acyl-CoA synthetase long-chain family member 4 (ACSL4). Here, we report the discovery of a photosensitizer, namely TPCI, which can evoke ACSL4-independent ferroptosis of cancer cells in photodynamic therapy. Through co-localization with 12-lipoxygenase (ALOX12) in multiple subcellular organelles, TPCI activates ALOX12 to generate lipid reactive oxygen species in large quantity and trigger cell ferroptosis. Intriguingly, confining TPCI exclusively in lysosomes switches the cell death from ferroptosis to apoptosis. More strikingly, the ferroptosis mediated by TPCI-induced ALOX12 activation does not require the participation of ACSL4. Therefore, our study identifies TPCI as the first ALOX12 activator to induce ferroptosis independent of ACSL4, which renders a viable therapeutic approach on the basis of distinct ferroptosis of cancer cells, regardless their ACSL4 expressions.
Quantification of gas-accessible microporosity in metal-organic framework glasses
Authors: Frentzel-Beyme Louis , Kolodzeiski Pascal , Weiß Jan-Benedikt , Schneemann Andreas , Henke Sebastian 
Published: December 2022

AbstractMetal-organic framework (MOF) glasses are a new class of glass materials with immense potential for applications ranging from gas separation to optics and solid electrolytes. Due to the inherent difficulty to determine the atomistic structure of amorphous glasses, the intrinsic structural porosity of MOF glasses is only poorly understood. Here, we investigate the porosity features (pore size and pore limiting diameter) of a series of prototypical MOF glass formers from the family of zeolitic imidazolate frameworks (ZIFs) and their corresponding glasses. CO2 sorption at 195 K allows quantifying the microporosity of these materials in their crystalline and glassy states, also providing excess to the micropore volume and the apparent density of the ZIF glasses. Additional hydrocarbon sorption data together with X-ray total scattering experiments prove that the porosity features of the ZIF glasses depend on the types of organic linkers. This allows formulating design principles for a targeted tuning of the intrinsic microporosity of MOF glasses. These principles are counterintuitive and contrary to those established for crystalline MOFs but show similarities to strategies previously developed for porous polymers.
Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens
Authors: Srivatsa Sumana , Montazeri Hesam , Bianco Gaia , Coto-Llerena Mairene , Marinucci Mattia , Ng Charlotte K. Y. , Piscuoglio Salvatore , Beerenwinkel Niko 
Published: December 2022

AbstractThe development of cancer therapies is limited by the availability of suitable drug targets. Potential candidate drug targets can be identified based on the concept of synthetic lethality (SL), which refers to pairs of genes for which an aberration in either gene alone is non-lethal, but co-occurrence of the aberrations is lethal to the cell. Here, we present SLIdR (Synthetic Lethal Identification in R), a statistical framework for identifying SL pairs from large-scale perturbation screens. SLIdR successfully predicts SL pairs even with small sample sizes while minimizing the number of false positive targets. We apply SLIdR to Project DRIVE data and find both established and potential pan-cancer and cancer type-specific SL pairs consistent with findings from literature and drug response screening data. We experimentally validate two predicted SL interactions (ARID1A-TEAD1 and AXIN1-URI1) in hepatocellular carcinoma, thus corroborating the ability of SLIdR to identify potential drug targets.
Merging enzymatic and synthetic chemistry with computational synthesis planning
Authors: Levin Itai , Liu Mengjie , Voigt Christopher A. , Coley Connor W. 
Published: December 2022

AbstractSynthesis planning programs trained on chemical reaction data can design efficient routes to new molecules of interest, but are limited in their ability to leverage rare chemical transformations. This challenge is acute for enzymatic reactions, which are valuable due to their selectivity and sustainability but are few in number. We report a retrosynthetic search algorithm using two neural network models for retrosynthesis–one covering 7984 enzymatic transformations and one 163,723 synthetic transformations–that balances the exploration of enzymatic and synthetic reactions to identify hybrid synthesis plans. This approach extends the space of retrosynthetic moves by thousands of uniquely enzymatic one-step transformations, discovers routes to molecules for which synthetic or enzymatic searches find none, and designs shorter routes for others. Application to (-)-Δ9tetrahydrocannabinol (THC) (dronabinol) and R,R-formoterol (arformoterol) illustrates how our strategy facilitates the replacement of metal catalysis, high step counts, or costly enantiomeric resolution with more elegant hybrid proposals.
Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome
Authors: Yao Chi , Xu Yuwei , Tang Jianpu , Hu Pin , Qi Hedong , Yang Dayong 
Published: December 2022

AbstractIntracellular accumulation of reactive oxygen species (ROS) leads to oxidative stress, which is closely associated with many diseases. Introducing artificial organelles to ROS-imbalanced cells is a promising solution, but this route requires nanoscale particles for efficient cell uptake and micro-scale particles for long-term cell retention, which meets a dilemma. Herein, we report a deoxyribonucleic acid (DNA)-ceria nanocomplex-based dynamic assembly system to realize the intracellular in-situ construction of artificial peroxisomes (AP). The DNA-ceria nanocomplex is synthesized from branched DNA with i-motif structure that responds to the acidic lysosomal environment, triggering transformation from the nanoscale into bulk-scale AP. The initial nanoscale of the nanocomplex facilitates cellular uptake, and the bulk-scale of AP supports cellular retention. AP exhibits enzyme-like catalysis activities, serving as ROS eliminator, scavenging ROS by decomposing H2O2 into O2 and H2O. In living cells, AP efficiently regulates intracellular ROS level and resists GSH consumption, preventing cells from redox dyshomeostasis. With the protection of AP, cytoskeleton integrity, mitochondrial membrane potential, calcium concentration and ATPase activity are maintained under oxidative stress, and thus the energy of cell migration is preserved. As a result, AP inhibits cell apoptosis, reducing cell mortality through ROS elimination.
Thermal and solute aspects among two viscosity models in synovial fluid inserting suspension of tri and hybrid nanomaterial using finite element procedure
Authors: Nazir Umar , Sohail Muhammad , Kumam Poom , Elmasry Yasser , Sitthithakerngkiet Kanokwan , Ali Mohamed R. , Khan Muhammad Jahangir , Galal Ahmed M. 
Published: December 2022

AbstractInclusion of nanoparticles boosts thermal performance and is essential for thermal transport. The current investigation has been made to conduct research on heat mass transport in synovial material with the mixing of hybrid and tri-hybrid comprising variable viscosity past over a heated surface having constant density and a steady environment. The conservation laws have been considered in the presence of Lorentz force, heat generation/absorption, modified heat and mass fluxes together with chemical reaction. The mathematical model is developed in Cartesian coordinate in the form of coupled partial differential equation (PDEs). The derived PDEs are simplified by a boundary layer approach (BLA) and reduced PDEs have been converted into ordinary differential equation (ODEs) using scaling group Similarity transformation. The converted ODEs are highly nonlinear and have been solved numerically by finite elements scheme (FES). The used scheme is effective for nonlinear problem and can be frequently utilized to tackle nonlinear problems arising in mathematical physics.
Broiler meat fatty acids composition, lipid metabolism, and oxidative stability parameters as affected by cranberry leaves and walnut meal supplemented diets
Authors: Untea Arabela Elena , Turcu Raluca Paula , Saracila Mihaela , Vlaicu Petru Alexandru , Panaite Tatiana Dumitra , Oancea Alexandra Gabriela 
Published: December 2022

AbstractA randomized complete block with a 2 × 3 factorial arrangement was used to design a nutrition experiment conducted for the evaluation of the relation between walnut meal (WM—6% inclusion rate) and cranberry leaves (CL—1% and 2% inclusion rate) supplements and their effects on tissue lipid profile, lipid metabolism indices and oxidative stability of meat. Semi-intensive system conditions were simulated for 240 Ross 308 broilers and the animals were reared on permanent shave litter in boxes of 3 m2 (40 broilers / each group, housed in a single box). The current study results showed that the diets enriched in linolenic acid (LNA) (WM diets) led to broilers meat enriched in LNA, but the synthesis of long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) was stimulated when the diets were supplemented with a natural antioxidants source (CL diets). The CL diet also exhibited the most powerful effect in counteracting the oxidative processes of meat.