bluuebunny/crossref_metadata_2025_split huggingface dataset:
RANCANG BANGUN TEMPAT SAMPAH OTOMATIS MENGUNAKAN MIKROKONTROLER DAN SENSOR ULTASONIK DENGAN NOTIFIKASI TELEGRAM
Authors: Sohor Suherman , Mardeni  , Irawan Yuda , Sugiati  
Published: January 2022

Sampah merupakan ancaman serius bagi masyarakat, karena membuang sampah sembarangan dapat menyebabkan pencemaran lingkungan, dalam meningkatkan kesadaran mahasiswa akan kepedulian terhadap kebersihan lingkungan maka perlu adanya sebuah tempat sampah otomatis. Penelitian ini dilaksanakan dikampus STMIK Hang Tuah Pekanbaru untuk membantu mahasiswa dan Cleaning Service dalam permasalahan sampah yang saat ini ada di kampus. Tempat sampah otomatis bertujuan untuk memberikan notifikasi melalui telegram kepada petugas Cleaning Service secara otomatis jika tempat sampah penuh. Tempat sampah otomatis ini juga bermanfaat dalam mempermudah pengguna untuk membuang sampah organik tanpa harus membuka sendiri tutup tempat sampahnya. Metode yang digunakan dalam penelitian ini merupakan metode prototype yaitu untuk mengetahui bagaimana sistem yang digunakan dapat berjalan dengan baik. Kesimpulan dari alat ini dapat mambantu mahasiswa dalam membuka dan menutup tempat sampah secara otomatis tanpa menyentuh secara langsung tempat sampah sehingga mahasiswa terhindari dari bau dan kotornya tempat sampah,tempat sampah otomatis ini juga membantu Cleaning Service dalam mengetahui kapasistas penuhnya tempat sampah dengan mengirim notifikasi melalui telegram .
Berwirausaha Kopi Di Masa Pandemi Corona Virus Disease 19 Di Kecamatan Medan Labuhan
Authors: Anshar Muhammad , Fahmi Teuku , Siregar Fandi Alfiansyah 
Published: January 2022

The Medan Mayor's policy of issuing a regional regulation on large-scale social restrictions forced the coffee shop entrepreneur to close down his business for several months. The purpose of this study was to determine the strategy of coffee shop owners in entrepreneurship during the Covid 19 pandemic, to find out the entrepreneurial communication mechanisms carried out by coffee shop owners and to find out the obstacles faced by coffee shop owners. This research is a qualitative descriptive study using survey and observation methods and data collection techniques are measured using interviews and documentation. The central and local governments have not provided assistance to coffee shop owners in the form of injections of funds to stay afloat and be entrepreneurial during the Covid 19 pandemic. The Medan city government should make joint policies with business actors in the city of Medan in general, especially coffee shop owners who have limited capital and coffee shop owners must have breakthrough ideas and new innovations in entrepreneurship to face the Covid 19 pandemic that has not ended.
Online Tadarus Quran Tanpa Suara (Online TTS): Cabaran Komuniti OKU Pekak
Authors: Khamaruddin Siti Ramna , Muhamad Nurul Asiah Fasehah , Mohd Raus Norakyairee 
Published: January 2022

Tadarus is a group Quran recitation activity that is usually carried out during the month of Ramadan. Although Ramadan is this time during the pandemic season, this activity is still actively being continued online. This situation is no exception for the deaf community. Taking inspiration to provide opportunities and space for them to participate with the Quran, using methods that celebrate their strength and learning disabilities, an online tadarus program called Online Tadarus Suara (Online TTS) was conducted using google meets platform. Therefore, this study aims to explore the challenges faced by the deaf community in the programme. The methodology used is the analysis of documents by analyzing the current reports of each facilitator on a daily basis and the feedback provided through the Google Form forms provided. In addition, researchers also perform observations to every TTS Online class recording on a daily basis. The findings showed that participants were able to participate in the TTS Online session well despite several challenges that could be categorised into two parts, namely internal and external challenges such as weaknesses in mastering Quran Hand Code, time and internet network access. However, it is hoped that this Quranic service will bring deaf people closer to the miracle of the Quran by celebrating the learning disability of this community based on visual strength.
Abstrak
Tadarus merupakan aktiviti pembacaan Quran secara berkelompok yang lazimnya dilakukan sewaktu bulan Ramadan. Walaupun Ramadan pada kali ini dalam musim pandemik, aktiviti ini masih giat diteruskan secara atas talian. Keadaan ini tidak berkecuali bagi komuniti OKU Pekak. Mengambil inspirasi untuk memberikan peluang dan ruang seluasnya bagi mereka turut serta berdamping dengan Quran, menggunakan kaedah yang meraikan kekuatan dan kelainan upaya belajar mereka, maka sebuah program tadarus secara atas talian iaitu Online Tadarus Tanpa Suara (Online TTS) telah dijalankan menggunakan platform Google Meets.Oleh yang demikian, kajian ini berhasrat untuk meneroka cabaran yang dihadapi oleh komuniti OKU Pekak dalam program tersebut. Metodologi yang digunakan ialah analisis dokumen dengan menganalisis laporan semasa setiap fasilitator pada setiap hari dan maklum balas yang diberikan melalui borang Google Form yang disediakan. Selain itu, pengkaji juga melakukan pemerhatian kepada setiap rakaman kelas Online TTS yang dilakukan pada setiap hari. Dapatan kajian menunjukkan peserta mampu mengikuti sesi sesi Online TTS dengan baik walaupun terdapat beberapa cabaran yang boleh dikategorikan kepada dua bahagian iaitu cabaran dalaman dan luaran seperti kelemahan menguasai KTQ, masa dan capaian rangkaian internet. Walau bagaimanapun, diharapkan khidmat Quran ini mampu mendekatkan OKU Pekak dengan mukjizat al-Quran dengan meraikan kelainan upaya belajar komuniti ini berasaskan kekuatan visual.
Розвиток комунікаційного менеджменту в умовах інформатизації суспільства
Authors: Храмцова Ю.В. 
Published: January 2022

В статті розкрито особливості комунікаційного менеджменту в сучасних умовах.
Розвиток комунiкацiйних тeхнологiй є актуальною характеристикою інформаційного суспільства. Формуються та розвиваються нові концeпти, такі як комунікаційний менеджмент в кризових ситуаціях, репутаційний менеджмент, бренд-менеджмент, новинний менеджмент, комунікаційна підтримка лобістської діяльності, комунікативна компетентність, комунікаційний аудит, комунікаційна безпека, нейтралізація маніпулятивних технологій, комунікаційний менеджмент і управління конфліктами, управління за допомогою невербальних і паравербальних комунікацій, інформаційні війни.
Автором проаналізовано визначення предмету комунікаційного менеджменту, зроблений висновок про відсутність єдиного науково-методичного підходу для розкриття змісту поняття комунікаційний менеджмент. Звернуто увагу, що сутність комунікаційного менеджменту має дуальну природу: комунікаційний менеджмент розглядається як самостійна прикладна професійна діяльність щодо практичного використання комунікаційних засобів, методів, інструментів, механізмів, що забезпечують формування та ефективний розвиток усіх видів капіталу організації. З другого боку, комунікаційний менеджмент – це наука, яка вивчає розділ управління щодо взаємодії і взаємозв'язку елементів в часі і просторі, які формують і ефективно використовують всі види капіталу організації, базуються на законах обміну інформацією з метою розвитку організації.
Ethics, neuropsychology and business communications through the prism of the contradictions of globalization and the information society
Authors: Наумік-Гладка К.Г. 
Published: January 2022

The article describes the problems of business communications in the context of globalization and the information society. Attention is drawn to the ethics of modern communication processes and the influence of neuropsychology as a fundamentally new approach to the formation of the communication space and the implementation of effective communications.
The study of the changes taking place in the social space is relevant. The content and direction of communication, ethical, social and psychological processes are influenced by the information society, and vice versa, since they are also factors of its development.
The idea of a balanced harmonious society becomes a problem in the context of contradictions between the processes of globalization and the integration of social processes, on the one hand, and the desire to preserve cultural identity, ethnic and religious integrity, individualization of the personal origin, on the other.
In the modern global communication space, there is a threat of violence in the form of terrorist acts, anomie, marginalization and other antisocial phenomena that destroy the principles of common human cultural ethics and morality, strengthening the trend of the spread of deviant behavior in society, and an increase in the number of mental disorders of the personality.
The multipolarity of the modern world order has exposed new problems focused primarily on the ethical, psychological, cultural and communicative sphere of social reality. The problems of the dialogue of cultures, religious consensus, tolerance, psychological stability and resistance to stress have become relevant in response to the need to solve the problem of uniting the economies of territories, political strategies, religions, cultures. The problem of using linguistics in the formation of consciousness and the culture of thinking is gaining importance.
Modern social, economic, technological conditions have become a factor in changing the consciousness of an individual in a very short time. Thus, main areas should be highlighted: the sphere of family and household relations; the sphere of education; the sphere of information and communication; the sphere of ethics and culture.
Вплив експортної переорієнтації України на діяльність підприємств: маркетингові та управлінські аспекти
Authors: Отенко В.І. , Птащенко О.В. , Корсунова К.Ю. , Карталія Д.М. 
Published: January 2022

У статті визначено основні проблеми управління акціонерним товариством України в умовах розгортання кризи, спричиненої пандемією Covid-19, та окреслено напрями їхнього подальшого розвитку за умови проєвропейського вектору руху економіки України. Серед основних проблем, висвітлених у статті, – недостатнє фінансування державою та місцевою владою провідних промислових підприємств та відсутність актуальних європейських партнерів. Незважаючи на велику кількість праць, присвячених дослідженню різних аспектів управління підприємствами в умовах експортної переорієнтації України з 2013 року, необхідно констатувати, що й досі основними ринками збуту для промислових підприємств є країни-члени СНД. Тобто, за 7 років переорієнтації зі Сходу на Захід, на західну та Південну Європу, структура експорту України змінилась не суттєво. Встановлено, що на сучасному етапі потребує подальшого вдосконалення основний закон щодо експортної діяльності – Закон України «Про зовнішньоекономічну діяльність», який саме і регламентує умови постачання українських товарів за кордон.
Процес ринкової трансформації національної економіки України свідчить про те, що держава повинна приймати довгострокові, стратегічні рішення в умовах економічної нестабільності та відсутності належного фінансування. На сьогодні, під тиском деяких визначальних факторів відбувається комунікаційний процес щодо стратегічного партнерства з ЄС і послаблення торгівельного зв'язку з країнами СНД та ЄЕС (Євразійський економічний союз).
ANALISIS ABILLITY TO PAY (ATP) DAN WILLINGNESS TO PAY (WTP) UNTUK PENETUAN TARIF PESAWAT RUTE PULAU TERNATE – PULAU BACAN
Authors: Mabud Zulaeha , Marsaoly Nurmaiyasa 
Published: January 2022

Penetapan tarif pesawat menjadi sangat penting jika dikaitkan dengan besar penggunaan peasawat terbang . Tujuan Penetapan tarif dimaksudkan untuk menjamin kelangsungan penyelenggaraan transportasi dengan mutu jasa yang sesuai standar keselamatan, dengan mempertimbangkan daya beli masyarakat serta pengaruhnya terhadap harga produksi. Metode analisis penentuan tarif pesawat terbang menggunakan ATP dan WTP, hasil metode tersebut bisa menentukan tarif terendah dan tertinggi sesuai pendapatan dan kemampuan membayar jasa pesawat.
Buffy Coat DNA Methylation Profile Is Representative of Methylation Patterns in White Blood Cell Types in Normal Pregnancy
Authors: Ghamrawi Ranine , Velickovic Igor , Milicevic Ognjen , White Wendy M. , Thistlethwaite Lillian Rosa , Cunningham Julie M. , Milosavljevic Aleksandar , Milic Natasa M. , Garovic Vesna D. 
Published: January 2022

Background: We aimed to assess the extent to which the buffy coat DNA methylome is representative of methylation patterns in constitutive white blood cell (WBC) types in normal pregnancy.Methods: A comparison of differential methylation of buffy coat DNA vs DNA isolated from polymorphonuclear (PMN) and lymphocytic fractions was performed for each blood sample obtained within 24 h prior to delivery from 29 normotensive pregnant women. Methylation profiles were obtained using an Illumina Human Methylation 450 BeadChip and CHaMP bioinformatics pipeline. A subset of differentially methylated probes (DMPs) showing discordant methylation were further investigated using statistical modeling and enrichment analysis.Results: The smallest number of DMPs was found between the buffy coat and the PMN fraction (2.96%). Pathway enrichment analysis of the DMPs identified biological pathways involved in the particular leukocyte lineage, consistent with perturbations during isolation. The comparisons between the buffy coat and the isolated fractions as a group using linear modeling yielded a small number of probes (∼29,000) with discordant methylation. Demethylation of probes in the buffy coat compared to derived cell lines was more common and was prevalent in shelf and open sea regions.Conclusion: Buffy coat is representative of methylation patterns in WBC types in normal pregnancy. The differential methylations are consistent with perturbations during isolation of constituent cells and likely originate in vitro due to the physical stress during cell separation and are of no physiological relevance. These findings help the interpretation of DNA methylation profiling in pregnancy and numerous other conditions.
Effective Dehydration of Fructose Over Stable Ti-Doped SBA-15 Catalysts
Authors: Zhu Yutong , Xu Xiaofei , He Jian , Guo Jie , Song Ke 
Published: January 2022

High-effective synthesis of 5-hydroxymethylfurfural (HMF) from carbohydrates is an interesting reaction among biomass valorization. The as-synthesized Ti-SBA-15 catalysts with mesoporous structures showed high catalytic efficiency for the conversion of fructose to HMF. Ti-SBA-15 catalysts with different Si/Ti ratios were characterized by characterization techniques such as elemental analysis, XRD, TEM, N2 adsorption–desorption, NH3-TPD, and pyridine-FTIR. The acidity of Ti-SBA-15 catalysts could be tuned by altering addition amount of titanium. The effects of reaction conditions, including reaction time, temperature, and amount of catalyst, on the conversions of fructose and the yields of HMF were also investigated. It is found that Ti-SBA-15 catalysts whose Si/Ti ratio is 120 gave the best yields of HMF, which demonstrated 100% conversion of fructose with a maximum HMF yield of 82% at 140°C after 1 h. In addition, its catalytic performance was retained after 5 recycles in fructose conversion reaction, proving its good catalytic stability.
Optimal Revascularization Strategy for Patients With ST-segment Elevation Myocardial Infarction and Multivessel Disease: A Pairwise and Network Meta-Analysis
Authors: Cui Kongyong , Yin Dong , Zhu Chenggang , Yuan Sheng , Wu Shaoyu , Feng Lei , Dou Kefei 
Published: January 2022

Background: The relative benefit of immediate complete revascularization, staged complete revascularization, and culprit-only percutaneous coronary intervention (PCI) remains unclear in hemodynamically stable patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease. The aim of this study was to compare the clinical outcomes of the 3 PCI strategies in this population.Methods: We followed a pre-specified protocol (PROSPERO number: CRD42020183801). A comprehensive search of the electronic databases including PubMed, EMBASE and Cochrane Library from inception through February 21, 2020 was conducted. Randomized trials evaluating the comparative efficacy and safety of at least 2 of the 3 PCI strategies were identified. The primary endpoint was the composite of cardiovascular mortality or myocardial infarction (MI) during the longest follow-up. Pairwise and network meta-analyses were performed with random-effects model.Results: Eleven trials including 6,942 patients were analyzed. Pairwise meta-analysis noted that immediate complete revascularization and staged complete revascularization were respectively associated with a 52 and 27% reduction in the risk of cardiovascular death or MI (relative risk [RR] 0.48, 95% confidence interval [CI] 0.32–0.73, I2 = 0%; and RR 0.73, 95% CI 0.61–0.88, I2 = 0%, respectively), compared with culprit-only PCI. The risk of cardiovascular death or MI was not statistically different in staged and immediate complete revascularization groups (RR 0.88, 95% CI 0.45–1.72, I2 = 0%). Network meta-analysis obtained almost similar results compared with pairwise meta-analysis, and immediate complete revascularization had a 77% probability of being the best strategy for reducing cardiovascular death or MI among the 3 PCI strategies.Conclusion: The current evidence suggests that both immediate and staged complete revascularization were associated with a reduction of cardiovascular death or MI compared with culprit-only PCI. Further trials are warranted to directly compare immediate vs. staged complete revascularization in this population.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, PROSPERO [CRD42020183801].
Exercise and Carotid Properties in the Young–The KiGGS-2 Study
Authors: Königstein Karsten , Büschges Julia Charlotte , Sarganas Giselle , Krug Susanne , Neuhauser Hannelore , Schmidt-Trucksäss Arno 
Published: January 2022

Background: Carotid intima-media thickness (cIMT) and stiffness (cS) are predictive markers of early vascular aging and atherosclerotic risk. This study assessed, whether exercise has protective effects on carotid structure and function or on vascular risk in the young.Methods: Volume and change of exercise (recreational and organized sports participation) of German adolescents and young adults was assessed within the prospective population-study KiGGS at KiGGS-Wave-1 (2009–2012) and KiGGS-Wave-2 (2014–2017) using standardized self-reporting questionnaires. CIMT and cS were measured by real-time B-mode ultrasound sequences with semi-automated edge-detection and automatic electrocardiogram-gated quality control in 2,893 participants (14–28 years, 49.6% female). A cumulative index for atherosclerotic risk (CV-R) included z-scores of mean arterial pressure, triglycerides, total/HDL-cholesterol-ratio, body mass index, and HbA1c.Results: At KiGGS-Wave-2 cross-sectional CV-R but not cS and cIMT was lower in all exercise-groups compared to “no exercise” (B = −0.73, 95%-CI = −1.26 to 0.19, p = 0.008). Longitudinal volume of exercise was negatively associated with CV-R (B = −0.37, 95%-CI = −0.74 to 0.00, p = 0.048) but not with cS and cIMT. Cross-sectional relative risk of elevated CV-R but not cS and cIMT was lower in all exercise-groups compared to “no exercise” (RR = 0.80, 95%-CI = 0.66 to 0.98, p = 0.033). High exercise volumes were associated with lower relative risk of elevated CV-R (RR = 0.80, 95%-CI = 0.65–0.97, p = 0.021) and cS in tendency but not with cIMT.Conclusions: Increased levels of exercise are associated with a better cardiovascular risk profile in young individuals, but not with cS and cIMT. Our study confirms previous recommendations on exercise in this age group without demonstrating a clear benefit on surrogate markers of vascular health.
Sensitive Quantification of Cell-Free Tumor DNA for Early Detection of Recurrence in Colorectal Cancer
Authors: Stasik Sebastian , Mende Marika , Schuster Caroline , Mahler Sandra , Aust Daniela , Tannapfel Andrea , Reinacher-Schick Anke , Baretton Gustavo , Krippendorf Claudia , Bornhäuser Martin , Ehninger Gerhard , Folprecht Gunnar , Thiede Christian 
Published: January 2022

The detection of plasma cell–free tumor DNA (ctDNA) is prognostic in colorectal cancer (CRC) and has potential for early prediction of disease recurrence. In clinical routine, ctDNA-based diagnostics are limited by the low concentration of ctDNA and error rates of standard next-generation sequencing (NGS) approaches. We evaluated the potential to increase the stability and yield of plasma cell–free DNA (cfDNA) for routine diagnostic purposes using different blood collection tubes and various manual or automated cfDNA extraction protocols. Sensitivity for low-level ctDNA was measured in KRAS-mutant cfDNA using an error-reduced NGS procedure. To test the applicability of rapid evaluation of ctDNA persistence in clinical routine, we prospectively analyzed postoperative samples of 67 CRC (stage II) patients. ctDNA detection was linear between 0.0045 and 45%, with high sensitivity (94%) and specificity (100%) for mutations at 0.1% VAF. The stability and yield of cfDNA were superior when using Streck BCT tubes and a protocol by Zymo Research. Sensitivity for ctDNA increased 1.5-fold by the integration of variant reads from triplicate PCRs and with PCR template concentration. In clinical samples, ctDNA persistence was found in ∼9% of samples, drawn 2 weeks after surgery. Moreover, in a retrospective analysis of 14 CRC patients with relapse during adjuvant therapy, we successfully detected ctDNA (median 0.38% VAF; range 0.18–5.04% VAF) in 92.85% of patients significantly prior (median 112 days) to imaging-based surveillance. Using optimized pre-analytical conditions, the detection of postoperative ctDNA is feasible with excellent sensitivity and allows the prediction of CRC recurrence in routine oncology testing.
EOGT Correlated With Immune Infiltration: A Candidate Prognostic Biomarker for Hepatocellular Carcinoma
Authors: Shu Yang , He Lingling , Gao Meixin , Xiao Fan , Yang Junru , Wang Shiwei , Wei Herui , Zhang Fuyang , Wei Hongshan 
Published: January 2022

BackgroundA preliminary study by our group revealed that the deficiency of EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT) impaired regulatory T-cell differentiation in autoimmune hepatitis. Nevertheless, the prognostic value of EOGT in advanced hepatocellular carcinoma (HCC) and its relationship with immune infiltration remain obscured.MethodsInitially, EOGT expression was evaluated by Oncomine, TIMER, GEO, and UALCAN databases. Besides, the prognostic potential of EOGT expression was analyzed using GEPIA, Kaplan–Meier plotter, CPTAC, Cox regression, and nomogram in HCC samples. Furthermore, we investigated the association between EOGT expression and tumor mutation burden, DNA methylation, and immune infiltration in addition to its possible mechanism via cBioPortal, TIMER, GEPIA, ESTIMATE, CIBERSORT, GSEA, STRING, and Cytoscape.ResultsThe expression of EOGT in HCC was significantly higher than that in normal tissues. Additionally, elevated EOGT expression was correlated with advanced tumor staging and linked to poor overall survival and relapse-free survival, serving as a significant unfavorable prognostic indicator in HCC patients. Remarkably, our results revealed that high-EOGT expression subgroups with elevated TP53 or low CTNNB1 mutations have worse clinical outcomes than the others. Regarding immune infiltration, immunofluorescent staining showed that immune cells in HCC were positive for EOGT. Besides, elevated EOGT expression was linked to exhausted T cells and immune suppressor cells in HCC samples. More importantly, the proportion of CD8+ T cells was reduced in HCC samples with a high level of EOGT expression, but EOGT did not exhibit prognostic potential in HCC samples with increased CD8+ T cells.ConclusionsEOGT may hold great potential as a novel biomarker to distinguish prognosis and immune profiles of HCC patients.