bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of Community Origin of major multidrug-resistant ESKAPE uropathogens in a paediatric population in South-East Gabon
Authors: Mouanga-Ndzime Yann , Onanga Richard , Longo-Pendy Neil M. , Bignoumba Michelle , Bisseye Cyrille 
Published: November 2022

Abstract
Background: Urinary tract infections (UTIs) in children are very common. They are often associated with a high risk of sepsis and death. In addition, antibiotic resistance of UTI pathogens isolated from children is steadily increasing, especially against commonly used antibiotics.
The study’s main objective was to examine the epidemiology of community origin and antibiotic sensitivity of major ESKAPE uropathogens in paediatric UTIs in South-East Gabon.
Methods:The study was conducted from January 2018 to December 2021 and involved 508 children aged 0-17 years. Identification of bacterial isolates was carried out using the Vitek-2 compact automated system and the antibiogram with the disk diffusion and microdilution methods according to the European Committee on Antimicrobial Susceptibility Testing recommendations.
Results: The prevalence of UTIs was 59%. E. coli and K. pneumoniae were the main ESKAPE involved in UTIs followed by Enterococcus spp. and S.aureus. The multidrug-resistant (MDR) phenotype was the most common. DTR-E. coli, CRE-K. pneumoniae and MDR-K. pneumoniae were associated with pyelonephritis. MRSA UTIs were frequent in symptomatic children. ESC-E. coli and MRSA were associated with recurrent UTIs while VRE and ESC-E. coli were associated with empirical treatment failures. MDR-E. coli, ESC-E. coli, MDR-K. pneumoniae, ESC-K. pneumoniae, UDR-K. pneumoniae, CRE-K. pneumoniae and XDR-K. pneumoniae were associated with rural paediatric populations.
Conclusion: This study describes the resistance phenotypes DTR, UDR and MAR index in Gabon. It showed a high prevalence of paediatric UTIs with high frequency of E. coli, K. pneumoniae, Enterococcus spp. and S. aureus with heterogeneous resistance profiles (MDR, XDR, DTR, ESC, CRE, MRSA and VRE).
Injectable platelet rich fibrin with demineralized freeze-dried bone allograft compared to demineralized freeze-dried bone allograft in intrabony defects of patients with stage-III periodontitis: A randomized controlled clinical trial Running head: I-PRF with DFDBA in periodontal intrabony defects
Authors: Alshoiby Mashaal Mohammed , El-Sayed Karim Fawzy , Elbattawy Weam , Hosny Manal 
Published: November 2022

Abstract
Aim: The current randomized controlled clinical trial assessed the effect of injectable platelets rich fibrin (I-PRF) combined with demineralized freeze-dried bone allograft (DFDBA) compared to DFDBA alone in the management of intrabony defects of stage-III periodontitis patients.
Methodology: Following sample size calculation, twenty stage-III periodontitis patients with ≥5mm clinical attachment level (CAL)-loss and ≥3mm intrabony defects were randomized into test (I-PRF+DFDBA; n=10) and control (DFDBA; n=10) groups. CAL (primary-outcome), periodontal probing depth (PPD), gingival recession depth (GRD), full-mouth plaque scores (FMPS), full-mouth bleeding scores (FMBS), radiographic linear defect depth (RLDD) and bone fill (secondary outcomes) were examined at baseline, 3, 6 and 9 months post-surgically.
Results: I-PRF+DFDBA and DFDBA independently demonstrated significant intragroup CAL-gain, PPD- and RLDD-reduction at 3, 6 and 9 months (p<0.05), with no significant intergroup differences observed (p>0.05). CAL-gain (mean±SD) of 2.40±0.70mm and 2.50±0.85mm and PPD-reduction of 3.50±1.18mm and 2.80±0.42mm were demonstrated for I-PRF+DFDBA and DFDBA at 9 months respectively. Both groups showed significant intragroup RLDD improvement, with a RLDD of 3.58±0.66mm and 3.89±1.57mm for I-PRF+DFDBA and DFDBA at 9 months respectively. Stepwise linear regression analysis revealed that baseline RLDD and bone fill at 9 months were significant predictors of CAL (p<0.05).
Conclusion: Within the present study’s limitations, DFDBA with or without I-PRF resulted in significant improvement in clinical and radiographic periodontal parameters in the surgical treatment of periodontal intrabony defects of stage-III periodontitis patients. Addition of I-PRF to DFDBA does not appear to significantly enhance the DFDBA’s reparative/regenerative outcomes.
Clinical relevance: Within the current study’s limitations, routinely adding I-PRF to DFDBA cannot be recommended to significantly improve DFDBA’s treatment outcomes of in intrabony defects.
Laser-induced X-ray fluorescence and electron-based X-ray emission analysis of multi-layer material
Authors: Kang Jungu , Ko Do-Kyeong 
Published: November 2022

Abstract
In this study, we analyzed the X-ray fluorescence of the multi-layer material with a laser-induced X-ray and electrons. The laser plasma based sources were generated by the femtosecond Ti: Sapphire laser source, and we optimized sources for the X-ray fluorescence measurement. The laser-induced X-ray fluorescence of three types of stainless steel, copper-covered stainless steel and three types of Korean 10 Won coins were measured using a compact laser with relatively low intensity. Using the difference in penetration depth between X-rays and electrons, the surface and interior of multi-layer materials can be analyzed simultaneously. By combining these two complementary sources, we can provide valuable information about the surface and interior of multi-layer materials even with the compact laser.
Drivers of Low-Frequency Sahel Precipitation Variability: Comparing CMIP5 and CMIP6 Ensemble Means with Observations
Authors: Herman Rebecca Jean , Biasutti Michela , Kushnir Yochanan 
Published: November 2022

Abstract
Phases 5 and 6 of the Coupled Model Intercomparison Project (CMIP5 and CMIP6) both grossly underestimate the magnitude of low-frequency Sahel rainfall variability; but unlike CMIP5, CMIP6 mean historical precipitation does not even correlate with observed multi-decadal variability. We demarcate realms of simulated physical processes that may induce differences between these ensembles and prevent both from explaining observations. We partition all influences on simulated Sahelian precipitation variability into five components: (1) teleconnections from sea surface temperature (SST); (2) atmospheric and (3) oceanic variability internal to the climate system; (4) the SST response to external radiative forcing; and (5) the “fast” (not mediated by SST) precipitation response to forcing. In a vast improvement from previous ensembles, the mean spectral power of Sahel rainfall in CMIP6 atmosphere-only simulations is consistent with observed low-frequency variance. The mean low-frequency variability is dominated by teleconnections from observed global SST, and the fast response only hurts its performance. We estimate that the strength of simulated teleconnections is consistent with observations using the previously-established North Atlantic Relative Index (NARI) to approximate the role of global SST, and apply this relationship to the coupled CMIP ensembles to infer that both fail to explain low-frequency historical Sahel rainfall variability mostly because they cannot explain the observed combination of forced and internal SST variability. Yet differences between CMIP5 and CMIP6 in mean Sahel precipitation and its correlation with observations do not derive from differences in NARI, but from the fast response to forcing or the role of other SST patterns.
Effects of near-fault and far-fault ground motions on seismic responses of multi-storey building structures controlled by tuned mass damper inerter
Authors: Abd-Elhamed Ayman 
Published: November 2022

Abstract
The tuned mass-damper-inerter (TMDI) is a newly developed passive energy dissipation unit that combines the conventional tuned mass-damper (TMD) with an inerter mechanism to attenuate undesirable vibrations. Far- and near-fault earthquake characteristics influence optimal TMDI parameters in controlling displacement demands on building structures. This study provides a comprehensive evaluation of the impact of TMDI on the structural response of linear-behaving multi-degree-of-freedom (MDOF) structures subjected to far-and near-fault earthquake-induced ground shaking. The chosen near-fault records guarantee motions with forward directivity (FD) and motions with fling step (FS). An approach based on a genetic algorithm (GA) is used to tackle the optimization problem. The objective function that needs to be minimized is the displacement of the building's top story. On the basis of predetermined mass and inertance ratios, the single-objective minimization method is used to compute the optimal design parameters (damping and frequency ratios). TMD and TMDI's optimal control capabilities are compared, and an inerter dependence analysis is conducted to probe the effect of the improvement. It is analytically demonstrated that the TMDI performs better than the conventional TMD for relatively small mass ratios, regardless the distance from a fault rupture. However, the TMD's high-mode dampening effect can be further enhanced by increasing the inertance of the inerter. Additionally, buildings excited by near-fault records with FS have a higher seismic demand on their induced responses. Lastly, the inerter's mass-amplification effect can either enhance the performance of the conventional TMD, for a certain TMD mass, or replace a portion of the TMD's oscillating mass, to realize a substantial weight reduction at a desired level of vibration suppression.
Genotypes and Viral Load of Hepatitis C Virus among HIV Patients Visiting ART Center of Nepal
Authors: Sah Uday Kant , Sah Anil Kumar , Ansari Mehraj , Sah Jay Prakash , Kumar Pawan 
Published: November 2022

Abstract
HIV patients are prone to various other complications, disorder and coinfections mainly HCV coinfection. HCV coinfection increases up the frequency and severity of liver disease. The aim of this study was to find the prevalence of HCV coinfection among HIV patients, HCV viral load and HCV genotypes in Nepal. This cross-sectional study was conducted from Oct 2021 to May 2022 in the HIV seropositive patients attending the Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal. All the demographic and blood samples were collected from the patients. The RNA was extracted and estimated the viral load and HCV genotypes by standard Q-PCR protocols. A total 203 PLHIV were enrolled in the study out of which 115 (56.6%) had HCV co-infection by Q-PCR. Most commonly HCV infection was higher in male 110 (95.6%) than female 5 (4.4%). HCV viral load < 34 IU/ml was observed as higher number 56 (27.6%) then 31 (15.3%) had among 34-3000 IU/ml, 17 (8.4%) had 3000–30000 IU/ml, 8 (3.9%) had 30000–300000 IU/ml and only 3 (1.5%) had > 3000000 IU/ml HCV viral load. Genotype 3 were most prevalent 36 (61.1%) then genotypes 5a, 6, 1 and 1a as 13 (22.1%), 6 (10.2%, 2 (3.3%) and 2 (3.3%) respectively. Genotype 3a was most prevalent genotypes and the presence of HCV genotype 6 in Nepalese patients may indicate a shift of HCV genotypes.
Physicomechanical properties of raw and comminuted pine and poplar shavings: Energy consumption, particle size distribution and flow properties
Authors: Tryjarski Paweł , Lisowski Aleksander , Gawron Jakub , Obstawski Paweł 
Published: November 2022

Abstract
The aim of this study was to assess the energy consumption during milling and cutting-milling of pine and poplar shavings and determination of particle size distribution (PSD) characteristics and mechanical properties of these materials. Cutting-milling process required less energy (in kJ·kg–1) than milling but maximum mass flow rate of shavings was significantly higher and thus the effective power requirement of knife mill during cutting was also higher. Comminution of plastic poplar shavings was more energy-consuming than harder pine shavings. These features influenced PSD, which was approximated with four mathematical models: Rosin-Rammler-Sperling-Bennett (RRSB), normal, logistic and lognormal. On the base of the best fitting (Radj2) for RRSB, detailed PSD parameters were calculated and all PSDs were described as ‘mesokurtic’, ‘fine skewed’ and ‘well-graded’. In comparison to milled shavings, cut-milled shavings had higher density, but were less compressible and had lower unconfined yield strength. However, cut-milled shavings had higher flowability because of lower cohesion and internal friction angles, because after cutting-milling particles were more spherical than elongated particles after milling. Cut-milled poplar shavings had more favourable mechanical parameters and better PSD characteristics, but required more energy for comminution than pine shavings.
Role of Yellow Wine in Homocysteine-induced Endothelial Progenitor Cell Function
Authors: Jiang chengjian , Zhang jieting , Hu songqing , Meng Liping , Chi Jufang , Zhai Xiaoya , Xing Yangbo , Xu Weiyuan , Guo Hangyuan 
Published: November 2022

Abstract
Background
Increased Hcy level is an independent risk factor for coronary heart disease (CHD). It was proposed that yellow rice wine improves Hcy-induced EPCs dysfunction and inhibits the development of atherosclerotic plaques. In this study, we observed whether yellow rice wine and red wine improve the properties of homocysteine (Hcy)-induced endothelial progenitor cells (EPCs).
Methods
The bone marrow of rats was extracted to isolate EPCs from the bone marrow cell suspension using density-gradient centrifugation. The cells were inoculated on culture plates coated with human fibronectin (HFN), to induce mononuclear cell differentiation into EPCs. Samples were divided into 5 groups including a control group. Western blotting. and NO assays were used respectively to observe the generation of eNOS, p-eNOS and NO. MTT and transwell assays were conducted. Apoptosis and in vitro angiogenesis of EPCs were determined.
Results
Compared with the control group, the potential for proliferation, migration and in vitro angiogenesis of EPCs decreased significantly following Hcy intervention (P < 0.01).The production of eNOS, NO and p-eNOS was significantly reduced (P < 0.01). Intervention with yellow rice wine and red wine significantly improved the effect of Hcy in EPCs (P < 0.01). Further, comparison with the control group indicated that the intervention also significantly improved the proliferation, migration and angiogenesis of EPCs in vitro (P < 0.05). Compared with the Hcy group, the alcohol group did not show significant functional changes in EPCs (P > 0.05). No impact on apoptotic function of EPCs was observed (P > 0.05). Hcy significantly lowers the capacity of proliferation, migration and in vitro angiogenesis of EPCs and reduces the production of eNOS, p-eNOS and NO.
Conclusion
Our results showed Hcy significantly lowers the capacity of proliferation, migration and in vitro angiogenesis of EPCs and reduces the production of eNOS, p-eNOS and NO,which indicates that yellow rice wine and red wine in small doses improve the functions of EPCs.
Examining the Antecedents of Job satisfaction among Public and Private Bank Employees in India
Authors: Biju Ajitha Kumari Vijayappan Nair , C Arathy 
Published: November 2022

Abstract
This paper examines antecedents of job satisfaction of Indian public and private bank employees, and it aims to explore the reason for the difference in job satisfaction between them. The study reveals that there is a substantial difference in terms of job satisfaction between public and private sector bank employees. The public sector bank employees are more satisfied than private-sector bank employees in India. The nature of the job undertaken, the job security and the influence of co-workers emerge as significant predictors of job satisfaction more among public sector bank employees than those in the private sector. Among the demographic characteristics of employees, the education and designation/title of employees have emerged as the best predictor for job satisfaction of public sector bank employees. But in private banks, the strong determents of job satisfaction are the title or designation of employees and experience. We suggest a reason for dissatisfaction can be linked to the recruitment process in banks, which is effective in public but not effective in private banks in India. Henceforth, we suggest that the need for urgent human resource policy intervention is essential for improving the efficacy and efficiency of private bank employees and reducing the severe attrition rate in private sector banks in India.
Informative Lagrange Multipliers in the Nonlinear Parametric Programming Model
Authors: Jie Tao , Yan Gao 
Published: November 2022

Abstract
The shadow price expresses the marginal cost with respect to the variation of constraints, and it is extremely useful in the sensitivity analysis of nonlinear programming models. However, the shadow price may fail to exist in particular parametric programming models, and the informative Lagrange multipliers are proposed to supplement the theory of the shadow price. The traditional analysis of informative Lagrange multipliers is based on the right hand side perturbation model, in which the resource constraints are assumed to be arbitrarily violated, and the variation of resources are measured by the perturbations. In the line of traditional analysis, the minimum norm Lagrange multiplier is proved to be informative since it expresses the rate of cost improvement per unit constraints violation along the steepest descent direction. However, the internal cause of the resource variations is neglected, and the minimum norm Lagrange multiplier may fail to be informative when the perturbations are not only on the right hand side of the constraints. In this paper, we extend the classical constraint violation condition to the generalized constraint violation condition, which captures the characteristic of the problem structure of nonlinear parametric programming models. Based on the generalized constraint violation condition, we provide sufficient conditions for the minimum norm Lagrange multiplier to be informative. Furthermore, we propose a kind of penalty function method to derive the informative LM in fully parametric programming models, which means that the perturbations are not only on the right hand side of the constraints. Finally, we use examples to support our theoretic results.
Emotion-Aware Brainstorm Optimization
Authors: Ntakolia Charis , Koutsiou Dimitra-Christina C. , Iakovidis Dimitris K. 
Published: November 2022

Abstract
Βrainstorm Optimization (BSO) is a swarm-intelligence clustering-based algorithm inspired by the human brainstorming process. Electromagnetism-like Mechanism for global Optimization (EMO) is a physics-inspired optimization algorithm. In this study we propose a novel hybrid metaheuristic evolutionary algorithm that combines aspects from both BSO and EMO. The proposed algorithm, named Emotion-aware Brainstorm Optimization (EBO), is inspired by the attraction-repulsion mechanism of electromagnetism, and it is applied in a new emotion-aware brainstorming context, where positive and negative thoughts produce ideas interacting with each other. Novel contributions include a bi-polar clustering approach, a probabilistic selection operator, and a hybrid evolution process, which improves the ability of the algorithm to avoid local optima and convergence speed. A systematic comparative performance evaluation that includes sensitivity analysis, convergence velocity and dynamic fitness landscape analyses, and scalability assessment was performed using several reference benchmark functions from standard benchmark suites. The results validate the performance advantages of the proposed algorithm over relevant state-of-the-art algorithms.
A Multidomain Intervention Program for Older People With Dementia: a Pilot Study
Authors: Nguyen Thanh Xuan , Vu Huyen Thi Thanh , Nguyen Tuan , Esterman Adrian , Tran Luc Viet , Thillainadesan Janani , Naganathan Vasikaran , Brodaty Henry 
Published: November 2022

Abstract
Background: Multidomain interventions have been shown to be effective in improving cognition, quality of life, reducing neuropsychiatric symptoms and delaying progression of functional impairment or disability in dementia patients. To investigate the multidomain intervention in other populations and diverse cultural and geographical settings, this pilot study will assess the feasibility of a multidomain intervention for older people with dementia in nursing homes in Vietnam. Methods: Participants will be randomized into two equal groups, to receive either an multidomain intervention (intervention group) or regular health advice (control group). The intervention will include physical, cognitive, and social interventions and management of metabolic and vascular risk factors. We will hypothesize that the multidomain intervention will be feasible in Vietnam, and participants who receive the intervention will show improvement in quality of life, behaviors, functional ability, cognitive function, sleep, and in reduction of falls, use of healthcare services, and death rate compared to those in the control group during the 6 months intervention period and after the 6 months extended follow-up.
Discussion: This is the first study to evaluate feasibility of a multidomain intervention program for older people with dementia in nursing homes in Vietnam. The results from the trial will inform clinicians and the public of the possibility of comprehensive treatment beyond simply drug treatments for dementia. It pave the way for further studies to evaluate the long-term effects of multidomain interventions in dementia patients. Futhermore, the research results will provide information on the effectiveness of multidomain interventions which will inform policy development on dementia.
Trial registration: The trial is registered with ClinicalTrials.gov identifier: NCT04948450.
Untargeted Metabolomics of Body Dysmorphic Disorder
Authors: Wang Yawen , Huang Jinlong 
Published: November 2022

Abstract
BDD (Body Dysmorphic Disorder) is a disorder associated with depression and eating disorders, often arising from minor defects in appearance or an individual's imagining that he or she is defective. However, the pathogenesis and mechanism of BDD are not clear, and its pathogenesis and adjuvant treatment methods still need to be explored. We employed an liquid chromatography-mass spectrometry (LC-MS)-based metabolomics approach to identify key metabolic differences in BDD. Plasma samples from 2 independent cohorts (8 BDD patients and 8 healthy controls) were collected to characterize metabolic changes in BDD patients. The raw data were subjected to the Compound Discovery program for peak alignment, retention time correction, and extraction of peak areas. Metabolite structure identification was performed using the Compound Discovery program by means of accurate mass matching (<10ppm) and secondary spectral matching to search the database. Multidimensional statistical analysis was performed using the R statistical software ropls tool, including unsupervised PCA (principal component analysis) analysis, supervised PLS-DA (partial least squares discriminant analysis) and OPLS-DA (orthogonal partial least squares discriminant analysis). Identify the most promising metabolic signatures associated with BDD across all metabolomic datasets. Occurrence of BDD may be related to ABC transporters, purine metabolism, Glycine, serine and threonine metabolism, Pyrimidine, Pyrimidine metabolism, Biosynthesis of 12-, 14- and 16-membered macrolides, microbial metabolism in diverse environments, Biosynthesis of secondary metabolites, Caffeine and Insect hormone biosynthesis.