bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal Super-Resolution Traffic Flow Forecasting via Continuous-Time Network Dynamics
Authors: Xie Yi , Xiong Yun , Zhang Jiawei , Chen Chao , Zhang Yao , Zhao Jie , Jiao Yizhu , Zhao Jinjing , Zhu Yangyong 
Published: September 2022

Abstract
Traffic flow forecasting is a critical task for Intelligent Transportation Systems. However, the existed forecasting can only be conducted at certain timestamps, because the data, is discretely collected at these timestamps. In contrast, traffic flow evolves in real-time in a continuous manner in the real world. Therefore, an ideal forecasting paradigm should be performed at arbitrary timestamps instead of only at these certain timestamps. Considering the forecasting timestamps will no longer be restricted by these timestamps, we call such a paradigm as temporal super-resolution forecasting. In this paper, we incorporate the idea of neural ordinary differential equations (Neural ODEs) to handle the problem, modeling the change rate of traffic flow on the urban road. Therefore, due to the continuous nature of ordinary differential equations, the traffic flow at arbitrary timestamps can be forecasted by performing a definite integral for the change rate. The urban road is usually regarded as a network, and the change rate of which can be described by continuous-time network dynamics, we parameterize the network dynamics of the traffic flow to quantify the change rate. On these foundations, we propose Spatial-Temporal Continuous Dynamics Network (STCDN) to complete the temporal super-resolution forecasting task. Extensive experiments on public traffic flow datasets illustrate that our model can achieve high accuracy on temporal super-resolution forecasting while ensuring its performance in conventional experimental settings at these certain timestamps.
Contrasting geochemical and fungal controls on decomposition of lignin and soil carbon at continental scale
Authors: Huang Wenjuan , Yu Wenjuan , Yi Bo , Raman Erik , Yang Jihoon , Hammel KE , Timokhin Vitaliy , Lu Chaoqun , Howe Adina , Weintraub-Leff Samantha , Hall Steven 
Published: September 2022

AbstractLignin is an abundant and complex plant polymer that may limit litter decomposition, yet lignin is sometimes a minor constituent of soil organic carbon (SOC). Accounting for geographic diversity in soil characteristics might reconcile this apparent contradiction. We tracked decomposition of a lignin/litter mixture across North American mineral soils using lab and field incubations. Cumulative lignin decomposition varied 18-fold among soils and was strongly correlated with bulk litter decomposition, but not SOC decomposition. Legacy climate predicted decomposition even in the lab. Impacts of nitrogen availability were minor compared with geochemical and microbial properties, which had contradictory relationships with lignin and SOC decomposition. Lignin decomposition increased with some metals and fungi, whereas SOC decomposition decreased with all metals and was weakly related with fungi. Soil properties differentially impact decomposition of lignin and litter vs. SOC across broad geographic scales, linking short-term decomposition to differences in organic matter among ecosystems.
Cardiac magnetic resonance assessment of an adult patient with left anterior descending artery arising from the pulmonary artery: surgical correction is risky
Authors: Yang Huiyuan , Wang Dongni , Dai Xu , Yu Yang 
Published: September 2022

Abstract
An anomalous left anterior descending coronary artery arising from the pulmonary artery (ALADAPA) is even much rare than anomalous left coronary artery arising from the pulmonary artery (ALCAPA). Early surgical correction is essential for classic ALCAPA, however, left circumflex (LCX) originating from aorta and well-developed collaterals in adult ALADAPA can minimize the risk of myocardial ischemia. It raised a question whether surgery correction is necessary in this community. We report a 45-year-old ALADAPA patient with apical myocardial necrosis and thrombus formatting after surgical treatment by using cardiac magnetic resonance (CMR) evaluation, which is generally considered to be associated with poorer clinical outcomes.
This rare case indicated that potential risk of surgical correction is non-negligible, the treatment decision for adult ALADAPA patients with mild syndrome should be made with greater caution when only moderate benefit is expected.
A New Robust Bootstrapped Singular Value Decomposition Algorithm Using the Sample Myriad Estimate
Authors: JOHN Chisimkwuo , EKPENYONG Emmanuel J. , NWORU Charles Chinedu , OMEKARA Chukwuemeka O. 
Published: September 2022

Abstract
Singular value decomposition (SVD) of rectangular datasets has proved to be a useful multivariate data decomposition approach because of its ability to decompose both square and rectangular matrices. Choi & Huh (1996) SVD approach utilizes the median as a robust location estimate other than the mean estimate used in the ordinary SVD. Since insufficient dataset and in addition, inefficiency of the median estimate seems to be a major setback of the existing robust SVD systems, this study envisaged an integrated algorithm that incorporated the BootSVD of Fisher (2016) and the sample Myriad estimate in cropping a new SVD system, the Robust Bootstrapped SVD (RobBootSVD). The new RobBootSVD was appraised alongside the existing ones using the Principal Component Analysis biplot quality measures and the new RobBootSVD T2 measure. Applications on tobacco process datasets with both short and long runs and simulated datasets with various percentages of outliers showcases the viability of the new approach.
JEL Classification: C11, C15, C19, C55
Knowledge, Attitudes and Acceptance towards COVID-19 Vaccination among Health Care Workers in Mukalla city-YEMEN: an analytical cross-sectional study
Authors: Bnqadeem Aseel , Alsabban Mohammed , Bokir Khulod , Al-Ghazali Ruqaiah , Gaber Sarah Bin Ali , Bahamran Marwan , Balfaqih Sumaia , Marei Fatima Bin , Al-Amodi Fatima , Barabaa Ahmed , Shamlan Aseel Bin , Aljaberi Ibrahim , Dahdah Khawla , Atash Sumaia 
Published: September 2022

Abstract
Background

COVID-19 vaccination is one of the greatest public health interventions to reduce the burden of the COVID-19 pandemic. Yemen began on April 2021 to vaccinate healthcare workers for COVID-19 with the vaccine. However, the media's negative portrayal of vaccines safety and efficacy has led to concerns regarding the acceptance of the vaccine. Therefore, our study aimed to assess knowledge, attitudes and acceptance towards COVID-19 Vaccination among HCWs in Mukalla city-Yemen.

Methods

An analytical cross-sectional study was conducted using convenience sampling method in Mukalla city among healthcare workers from April 2022 to May 2022. Data were collected by a self-administered questionnaire. A Chi-square test was used to assess the association between independent variables (demographic) and dependent variables (knowledge, attitude and acceptance). Correlation between knowledge and attitude levels with rate of acceptance was assessed using Pearson correlation coefficient.

Results

449 respondents were included in the final analysis, of which 237 (52.8%) were males and 212 (47.2%) were females, with a mean age ± SD of 31.0 ± 7.6 years. The overall results regarding knowledge, attitude, and acceptance rates of the COVID-19 vaccines were 65.3% 63.7% and 68.8% (with an efficacy of 90%), respectively. Acceptance was statistically associated with participants’ job, vaccination state, whether they were dealing with suspected cases of COVID-19 and their source of COVID-19 related information (p-value < 0.05). level of acceptance was moderately correlated with attitude level (r = 0.527).

Conclusion

Healthcare workers were found to have a moderate level of knowledge and attitude toward COVID-19 vaccination. However, acceptance rate was scaling down according to vaccine efficacy. Many demographic characteristics were significantly associated with acceptance of COVID-19 vaccination.
Multi-modal, Multi-task, Music BERT: A Context-Aware Music Encoder Based on Transformers
Authors: Greer Timothy , Shi Xuan , Ma Benjamin , Narayanan Shrikanth 
Published: September 2022

Abstract
Computational machine intelligence approaches have enabled a variety of music-centric technologies in support of creating, sharing and interacting with music content. A strong performance on specific downstream application tasks, such as music genre detection and music emotion recognition, is paramount to ensuring broad capabilities for computational music understanding and Music Information Retrieval (MIR). Traditional approaches have relied on supervised learning to train models to support these music-related tasks. However, such approaches require copious annotated data and still may only provide insight into one view of music—namely, that related to the specific task at hand. We present a new model for supporting music understanding that leverages self-supervision and cross-domain learning. After pre-training using masked reconstruction and self-attention bi-directional transformers, the model is fine-tuned using several downstream music understanding tasks. The results show that our multi-modal, multi-task, music transformer model, which we call M3BERT, generates features that result in better performance on several music-related tasks, indicating the potential of self-supervised and semi-supervised learning approaches toward a more generalized and robust computational approach to modeling music. Our work can offer a starting point for many music-related modeling tasks, with potential applications in learning deep representations and enabling robust end technology applications.
Sexual dysfunction worsen both the general and specific quality of life of women with irritable bowel syndrome. A cross-sectional study
Authors: Camacho Santiago , Díaz Andrea , Pérez Paulina , Batalla Héctor , Flores Yoshua , Altamirano Evelyn , Tijera María de Fátima Higuera-de la , Murguía Daniel , Gómez-Laguna Laura 
Published: September 2022

Abstract
Background: Irritable bowel syndrome (IBS) and sexual dysfunction (SxD) lowers quality of life (QOL) separately, but the effect of their overlap in unselected populations has not been studied. Objective: To evaluate the QOL of IBS women with and without SxD and compare it with controls. Methods: In this cross-sectional assessment, we studied 51 IBS women (Rome IV criteria) and 54 controls. SxD was determined using the female sexual function index questionnaire. QOL was evaluated by the Short Form 36 (SF-36) and IBS-QOL questionnaires. Results: SxD prevalence was similar between IBS women (39.22%) and controls (38.89%). Compared with other groups, IBS patients with SxD showed lower scores in all domains as well as in the physical, mental summaries of the SF-36 and almost all domains (except for body image, food avoidance, and social reaction compared with IBS patients without SxD) and the total score of IBS-QOL. Conclusions: These findings show that SxD worsens both general and specific QOL of women with IBS. The consideration of SxD in patients with IBS will allow us to make a more effective diagnostic and therapeutic approach. Clinical trial registry in Mexico City General Hospital: DI/19/107/03/080. Clinical trials registration: NCT04716738.
Effects of combined resistance and interval training in females with nonalcoholic fatty liver disease
Authors: Esmaeili Sima 
Published: September 2022

Abstract
Background
Nonalcoholic fatty liver disease (NAFLD) describes liver inflammation due to excessive fat accumulation and leading to conditions such as liver failure or cirrhosis. Exercise and physical activity can potentially reduce fat levels in the liver. Also, it is shown that combined resistance and interval training (CRIT) is a stronger stimulation for reducing inflammation, through decreasing body fat. Therefore, this study investigated the effect of CRIT on serum levels of fibroblast growth factor 21, fetuin-A, aspartate aminotransferase, alanine aminotransferase, insulin resistance, and lipid profile in females with nonalcoholic fatty liver disease.
Methods
Twenty-nine females (age range: 49.92 ± 7.16 years) with NAFLD participated in this study and were randomly divided into CRIT (n = 17) and control (n = 12) groups. The CRIT group did combined body weight resistance and interval exercises for eight weeks (three times a week and 40 minutes per session) with a constant increase in the workload, while the individuals in the control group followed their routine daily activities.
Results
Eight weeks of CRIT decreased fetuin-A, HOMA-IR, LDL and increased HDL and fibroblast growth factor 21. Levels of liver enzymes such as ALP, ALT and AST were also decreased by eight weeks of CRIT.
Conclusion
Eight weeks of CRIT improved liver enzymes, body composition, lipid profiles, and the serum levels of two hepatokines (fetuin-A and FGF-21) in inactive obese females with NAFLD. Our findings support the view that CRIT may be an effective non-medical therapeutic strategy to decrease NAFLD risk factors and obesity-induced disorders.
Phase separation to visualize protein-protein interactions and kinase activities in planta
Authors: Safi Alaeddine , Smagghe Wouter , Goncalves Amanda , Cappe Benjamin , Riquet Franck , Mylle Evelyn , Damme Daniël Van , Geelen Danny , De Jaeger Geert , Beeckman Tom , Leene Jelle Van , Vanneste Steffen 
Published: September 2022

Abstract
Protein complex formation and dynamic post-translational modifications are notoriously difficult to monitor at cellular resolution. Here, we developed a versatile modular toolbox of fluorescently labelled, artificial homo-oligomerizing peptide-tags (HOTag) that install interaction-dependent liquid-liquid phase-separation upon interaction between two proteins of interest. We deployed our novel toolbox for the in planta visualization of inducible, binary and ternary protein-protein interactions (PPIs), as well as specific phosphorylation, showing its great potential to become a robust standard technique to study PPIs and phosphorylation in plants.
Shortness of breath on day 1 after surgery alerting the presence of postoperative pulmonary complications in patients with lung cancer
Authors: Yu Qingsong , Yu Hongfan , Xu Wei , Pu Yang , Nie Yuxian , Dai Wei , Wei Xing , Wang Xin Shelley , Cleeland Charles S , Li Qiang , Shi Qiuling 
Published: September 2022

Abstract
Background: Patient-reported outcome (PRO)-based symptom assessment with a threshold can facilitate the early alert of adverse events. The purpose of this study was to determine whether shortness of breath (SOB) on postoperative day 1 (POD1) can inform postoperative pulmonary complications (PPCs) for patients after lung cancer (LC) surgery.
Methods: Data were extracted from a prospective cohort study of patients with LC surgery. Symptoms were assessed by the MD Anderson Symptom Inventory-lung cancer module (MDASI-LC) before and daily after surgery. Types and grades of complications during hospitalization were recorded. SOB and other symptoms were tested for a possible association with PPCs by logistic regression models. Optimal cutpoints of SOB were derived, using the presence of PPCs as an anchor.
Results: Among 401 patients with complete POD1 MDASI-LC and records on postoperative complications, 46 (11.5%) patients reported grade Ⅱ-Ⅳ PPCs. Logistic regression revealed that higher SOB score on POD1 (odds ratio [OR]=1.13, 95% CI=1.01-1.27), male(OR=2.86, 95% CI=1.32-6.23), open surgery (OR=3.03, 95% CI=1.49-6.14), and lower forced expiratory volume in one second (OR=1.78, 95% CI=1.66-2.96) were significantly associated with PPCs. The optimal cutpointwas 6 (on a 0-10 scale) for SOB. Patients reporting SOB < 6 on POD1 had shorter postoperative length of stay than those reporting 6 or greater SOB (median, 6 vs. 7, P =0.007).
Conclusion: SOB on POD1 can inform the onset of PPCs in patients after lung cancer surgery. PRO-based symptom assessment with a clinically meaningful threshold could alert clinicians for the early management of PPCs.
Mast Cells Released Inflammatory Markers Play a Vital Role in Mandibular Remodeling of Odontogenic Keratocyst Patients
Authors: Malik Zulaikha , Mirza Armaghan Israr , Akram Muhammad Adnan , Arshad Adnan , Kiyani Amber 
Published: September 2022

Background: Odontogenic Keratocyst (OKC) falls among the distinctive and rare odontogenic developmental cyst which is derivative of the dental lamina and contains clear fluid along with a cheesy material which resembles keratin debris. Treatment strategies for OKC are for the most part classified as conservative or aggressive. Mast Cells play an important role in the pathogenesis of inflammatory conditions. Objective: The goal of our study was to observe the participation of inflammatory mediators (RANKL, TNF-α, TGF-β and MMP-9) in the pathogenesis as well as the recovery process of OKC. Methods: Enrolled patients were divided into three groups while a fourth group was formed of the control individuals. Sampling of all groups was done once after required data collection. Blood samples were taken, mRNA extraction and cDNA was then subjected to qRT-PCR. IHC for mast cells was done on patient samples. Results: qRT-PCR showed higher expressions of inflammatory markers in patients undergoing treatment as compared to individuals with completed treatment procedure. Levels of RANKL were high in patients that were currently undergoing bone development as compared to other patients. The levels of TNF-α were comparatively higher in patients who showed visible signs of inflammation like swelling and pain. TGF-β and MMP-9 expression levels showed correlation with each other in all three groups. Both these cytokines were also found to be in association with mast cells. The results of histochemical staining of mast cells suggested the involvement of these cells in the pathogenesis of the cystic lesion via inflammation. Conclusions: The findings of the study suggest that the expressions of inflammatory mediators correlate with the presence of mast cells, therefore, application of mast cells stabilizers in addition to marsupialization in the treatment of OKC can be a prospective treatment strategy in future clinical settings.
Comparative Combinatorial Implications and Theranostics of Immunotherapy in
the Impediment of Alveolar Soft Part Sarcoma
Authors: Fan Ruitai , Yang Ya , Beeraka Narasimha M. , Liu Junqi , Zuo Xiaoxiao , Wang Xin , Li Tingxuan 
Published: September 2022

Background:
Immune checkpoint inhibitors (ICIs), specifically programmed cell death receptor-1/ligand 1 (PD-1/L1) inhibitors, have shown potential pharmacological efficacy in several cancers. Nonetheless, data pertinent to their therapeutic efficacy in alveolar soft-part sarcoma (ASPS) are limited.

Objective:
The retrospective aspects of ICIs (anti-PD1/PD-L1 blockers) to target ASPS comparatively analyzed for clinical outcomes with other targeted immunotherapy modalities.

Methods:
We have conducted a systematic review without statistical analysis or comprehensive meta-analysis by collecting the articles published between 1952 and Sep 10th, 2020 by searching the following words: alveolar soft part sarcoma and immunotherapy including immune checkpoint, immune checkpoint inhibitors, and PD-1, PD-L1. We performed a pooled analysis of case reports, conferences, clinical trials, and other research reports pertinent to the efficacy of a PD-1 or PD-L1 antagonist in patients diagnosed with metastatic ASPS.

Results:
The effective studies include 10 case reports, 2 conference reports, 5 clinical trials, and 2 additional research reports. Total 110 patients were reported to be enrolled in the pooled analysis; among them, 87 (78.38%) received a PD-1/PD-L1 antagonist. Patients who received anti-PD-1/PD-L1as monotherapy, then their clinical response rates (CRR) were 63.22% whereas the patients who received targeted therapy and immunotherapy, their CRR was 78.95% (15/19). The patients treated with double immunotherapy, their CRR was 100% (4/4). Tumor mutational burden and mismatch repair status have significant implications to predict the prognosis of ASPS.

Conclusion:
Alveolar soft-part sarcoma patients with distant metastases can exhibit better clinical outcomes with immunotherapy, particularly toripalimab, atezolizumab, and axitinib combinatorial regimen with pembrolizumab. In addition, this review describes the therapeutic implications to guide personalized medicine depending on the expression patterns of PD-1/PD-L1 during the immunotherapy with ASPS.
Involvement of Metabolites and Non-coding RNAs in Diseases
Authors: Coskun Kubra A. , Kıyak Bercem Yeman , Cifci Kezban Ucar , Kadioglu Elif , Yurekli Nazlican , Tutar Yusuf 
Published: September 2022

Abstract:
Non-coding RNAs have a role in gene regulation and cellular metabolism control. Metabolism
produces metabolites which are small molecules formed during the metabolic process. So
far, a direct relationship between metabolites and genes is not fully established; however, pseudogenes
and their progenitor genes regulate health and disease states. Other non-coding RNAs also
contribute to this regulation at different cellular processes. Accumulation and depletion of metabolites
accompany the dynamic equilibrium of health and disease state. In this study, metabolites, their
roles in the cell, and the link between metabolites and non-coding RNAs are discussed.
Bidirectional Relations Between Anxiety, Depression, and Cancer: A Review
Authors: Montazersaheb Soheila , Soofiyani Saiedeh Razi , Nakhlband Ailar , Farahzadi Raheleh , Saeedi Nazli , Barzegar Habibeh 
Published: September 2022

Abstract:
Epidemiological evidence continues to accumulate on the effect of stress and depression on cancer initiation and progression. Depression has been introduced as an independent predictor of increased cancer mortality. At the same time, early intervention for depression increases the surviv-al rate. Even some evidence has given prognostic value for depression to predict cancer recurrence and mortality. This article presents current evidence on the correlations of molecular mechanisms of cancer and depression through; I. The evidence shows the role of pre-existing depression and anxie-ty in the development and progression of cancer. II. The Immune system performs a crucial role in stress, depression, and cancer. III. The role of stress and depression-induced inflammation. IV. The evidence has proposed that cancer may result in depression and the effect of depression on cancer outcomes. In conclusion, the importance of preventive interventions to monitor patients’ mental health during cancer treatment is very significant and should not be underestimated. In other words, the initial interventions can improve depressive symptoms and increase cancer survival. On the oth-er hand, by identifying key biomarkers of depression, physicians can identify cancer patients at risk for depression or those who may not respond to routine treatments. Revealing the molecular mecha-nism of the cancer microenvironment in the development of comorbidities promises innovative therapeutic options for cancer. Identifying these mechanisms opens a new avenue in identifying cancer patients at risk for depression and can also provide considerable potential in identifying de-pressive patients prone to cancer.