bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on numerical solution algorithm for real‐time hybrid simulation of high‐speed railway on suspension bridge
Authors: Guo Wei , Zhang Rui , Hu Jingyi , Wang Yang 
Published: November 2022

AbstractReal‐time hybrid simulation combines experimental substructure and numerical substructure and is an effective method to study the dynamic response of coupled vibrations on high‐speed railway. This paper constructs a semi‐active suspension‐train‐suspension bridge coupling real‐time hybrid framework and a real‐time hybrid simulation method based on a neural network is proposed, which uses a long‐short‐term memory model instead of a complex train‐bridge structure model, evaluates the prediction performance of the trained network models through time history, regression analysis, and normalization error distribution. Finally, the network model is applied to a real‐time hybrid simulation, the accuracy and real‐time ability of the method are verified, and the results show that the proposed method can effectively improve the accuracy and efficiency of solving the numerical substructure.
Immune status of the murine 22q11.2 deletion syndrome model
Authors: Crockett Alexis M. , Kebir Hania , Benallegue Naïl , Adelman Philippa , Gur Raquel E. , Sullivan Kathleen , Anderson Stewart A. , Alvarez Jorge I. 
Published: November 2022

AbstractMice modeling the hemizygous deletion of chromosome 22q11.2 (22qMc) have been utilized to address various clinical phenotypes associated with the disease, including cardiac malformations, altered neural circuitry, and behavioral deficits. Yet, the status of the T cell compartment, an important clinical concern among 22q11.2 deletion syndrome (22qDS) patients, has not been addressed. While infancy and early childhood in 22qDS are associated with deficient T cell numbers and thymic hypoplasia, which can be severe in a small subset of patients, studies suggest normalization of the T cell counts by adulthood. We found that adult 22qMc do not exhibit thymic hypoplasia or altered thymic T cell development. Our findings that immune cell counts and inflammatory T cell activation are unaffected in 22qMc lend support to the hypothesis that human 22qDS immunodeficiencies are secondary to thymic hypoplasia, rather than intrinsic effects due to the deletion. Furthermore, the 22q11.2 deletion does not impact the differentiation capacity of T cells, nor their activity and response during inflammatory activation. Thus, 22qMc reflects the T cell compartment in adult 22qDS patients, and our findings suggest that 22qMc may serve as a novel model to address experimental and translational aspects of immunity in 22qDS.
Review and outlook of global energy use under the impact of COVID‐19
Authors: Zhang Dongdong , Rong Cunhao , Ahmad Tanveer , Xie Haonan , Zhu Hongyu , Li Xiang , Wu Thomas 
Published: November 2022

AbstractBy collecting and sorting the energy demand data of developing and developed countries, this paper makes a comprehensive analysis of their energy demand, including the change of energy demand and the change trend of energy load in various sectors. The survey scope of the article includes the overall change trend of energy supply, natural gas, oil, electricity, coal, renewable energy (such as wind energy, solar energy, geothermal energy, tidal energy, etc.), and the data change of global carbon dioxide emission. Besides, this paper selects a variety of energy sources for comprehensive analysis to analyze the existing change trend in chronological order. The analysis methods include data statistics of primary energy production and consumption, energy intensity analysis of gross domestic product (GDP), production, and demand balance of oil, natural gas, and coal, and study the trade balance between different types of energy in different countries and regions. The regions examined in this review include the organization for economic cooperation and development (OECD); the group of seven (G7); Brazil, Russia, India, China and South Africa (BRICs); the European Union; Europe; North America; the Commonwealth of Independent States (CIS); Asia; Latin America; the Pacific Ocean; the Middle East and Africa. By studying these data, we can make a better summary of the current energy use, so as to conveniently grasp the context of energy development and have a general understanding of the current energy structure. Therefore, individuals and policymakers in the fields of energy trade can think more deeply about the future situation and draw conclusions.
Reliable and Representative Estimation of Extrapolation Model Application in Deriving Water Quality Criteria for Antibiotics
Authors: Cao Leiping , Liu Ruimin , Wang Linfang , Liu Yue , Li Lin , Wang Yue 
Published: November 2022

Abstract
Deriving water quality benchmarks based on the species sensitivity distribution (SSD) is crucial for assessing the ecological risks of antibiotics. The application of extrapolation methods such as interspecies correlation estimation (ICE) and acute-to-chronic ratios (ACRs) can effectively supplement insufficient toxicity data for these emerging contaminants. Acute-to-chronic ratios can predict chronic toxicity from acute toxicity, and ICE can extrapolate an acute toxicity value from one species to another species. The present study explored the impact of two extrapolation methods on the reliability of SSDs by analyzing different scenarios. The results show that, compared with the normal and Weibull distributions, the logistic model was the best-fitting model. For most antibiotics, SSDs derived by extrapolation have high reliability, with 82.9% of R2 values being higher than 0.9, and combining ICE and ACR methods can bring a maximum increase of 10% in R2. Based on the results of Monte Carlo simulation, the statistical uncertainty brought by ICE in SSD is 10–40 times larger than that brought by ACR, and combining the two methods could reduce uncertainty. In addition, the sensitivity test showed that whether the toxicity data came from extrapolation or actual measurement, the lower the value of toxicity endpoints was, the greater the bias caused by the corresponding species in every scenario. Combining the two aforementioned extrapolation methods could effectively increase the stability of SSD, with their bias nearly equal to 1. Environ Toxicol Chem 2023;42:191–204. © 2022 SETAC
Copy Number Variation and Structural Genomic Findings in 116 Cases of Sudden Unexplained Death between 1 and 28 Months of Age
Authors: Brownstein Catherine A. , Douard Elise , Haynes Robin L. , Koh Hyun Yong , Haghighi Alireza , Keywan Christine , Martin Bree , Alexandrescu Sanda , Haas Elisabeth A. , Vargas Sara O. , Wojcik Monica H. , Jacquemont Sébastien , Poduri Annapurna H. , Goldstein Richard D. , Holm Ingrid A. 
Published: November 2022

AbstractIn sudden unexplained death in pediatrics (SUDP) the cause of death is unknown despite an autopsy and investigation. The role of copy number variations (CNVs) in SUDP has not been well‐studied. Chromosomal microarray (CMA) data are generated for 116 SUDP cases with age at death between 1 and 28 months. CNVs are classified using the American College of Medical Genetics and Genomics guidelines and CNVs in our cohort are compared to an autism spectrum disorder (ASD) cohort, and to a control cohort. Pathogenic CNVs are identified in 5 of 116 cases (4.3%). Variants of uncertain significance (VUS) favoring pathogenic CNVs are identified in 9 cases (7.8%). Several CNVs are associated with neurodevelopmental phenotypes including seizures, ASD, developmental delay, and schizophrenia. The structural variant 47,XXY is identified in two cases (2/69 boys, 2.9%) not previously diagnosed with Klinefelter syndrome. Pathogenicity scores for deletions are significantly elevated in the SUDP cohort versus controls (p = 0.007) and are not significantly different from the ASD cohort. The finding of pathogenic or VUS favoring pathogenic CNVs, or structural variants, in 12.1% of cases, combined with the observation of higher pathogenicity scores for deletions in SUDP versus controls, suggests that CMA should be included in the genetic evaluation of SUDP.
Ordovician continental arc magmatism in the Tam Ky‐Phuoc Son Suture Zone, Central Indochina Block, Southeast Asia
Authors: Ngo Thanh Xuan , Bui Hau V. , Tran Dung M. , Kim Yoonsup , Xiaochun Li , Tran Hai T. , Kwon Sanghoon , Jang Yirang , Sang Bui V. , Khang Luong Q. 
Published: November 2022

The Indochina Block is considered as a part of the Indian and Australian margins of Gondwana, and the Tam Ky‐Phuoc Son Suture Zone (TPSZ) lies in its central region as the boundary between the Truong Son Belt and Kon Tum Massif (KTM). However, the early Palaeozoic tectonic nature and timing of magmatism within the TPSZ are still controversial. To tackle the issue, we present herein the zircon U–Pb ages with their trace‐element compositions of five dioritic–granitic granitoids in the TPSZ. U–Pb age dating of magmatic zircons from them suggests emplacement ages of ca. 447–450 Ma. Whole‐rock geochemistry of the samples shows low TiO2 contents (0.36–1.18 wt%) and Mg# (42.04–53.07). They display enrichment in light rare earth elements ([La/Yb]N = 4.10–15.19), pronounced negative Nb, Ta and Ti anomalies relative to the chondrite‐normalized rare earth element patterns and primitive mantle‐normalized trace‐element distribution diagrams. The whole‐rock geochemical characteristics together with zircon trace‐element compositions from the same samples revealed their petrogenesis of a continental arc tectonic setting. Combining the results from this study together with available data from the TPSZ and its neighbouring units, we suggest accretionary orogenesis was responsible for generation of the Ordovician magmatic arc in the KTM, which will provide better understanding of the Early Palaeozoic evolution of the eastern Indochina Block.
GPR56 S4 variant is required for microglia‐mediated synaptic pruning
Authors: Li Tao , Luo Rong , Schmidt Rachael , D'Alessandro Nicholas , Kishore Priya , Zhu Beika , Yu Diankun , Piao Xianhua 
Published: November 2022

AbstractADGRG1 (also called GPR56) plays critical roles in brain development and wiring, including cortical lamination, central nervous system (CNS) myelination, and developmental synaptic refinement. However, the underlying mechanism(s) in mediating such diverse functions is not fully understood. Here, we investigate the function of one specific alternative splicing isoform, the GPR56 splice variant 4 (S4), to test the hypothesis that alternative splicing variants of GPR56 in part support its different functions. We created a new transgenic mouse line, Gpr56∆S4, using CRISPR/Cas9, in which GPR56 S4 was deleted. Detailed phenotype analyses show that Gpr56∆S4 mice manifest no deficits in cortical architecture and CNS myelination compared to controls. Excitingly, they present significantly increased synapse densities, decreased synapse engulfment by microglia, and impaired eye‐segregation. Taken together, our findings support that the GPR56 S4 variant is dispensable for cortical development and CNS myelination but is essential for microglia‐mediated synaptic pruning.
The impact of violence on healthcare workers' mental health in conflict based settings amidst COVID‐19 pandemic, and potential interventions: A narrative review
Authors: Rija Aiman , Islam Zarmina , Bilal Wajeeha , Qamar Khulud , Gangat Shazil Ahmed , Abbas Samina , Mirha Hania Tul , Mohanan Parvathy , Rahmat Zainab Syyeda , Shaeen Sean Kaisser , Djedid Selma Nihel Klouche , Essar Mohammad Yasir , Kashyap Rahul 
Published: November 2022

AbstractHealthcare workers (HCWs) have faced an increased amount of mental health struggles amidst the COVID‐19 pandemic. However, those in conflict‐based settings with fragile healthcare systems meet additional challenges. This study reviews violence, conflict and mental health among HCWs in five countries: Syria, Palestine, Yemen, Afghanistan and Lebanon. Our study reports that HCWs are targeted by violence, bombings, mistreatment and different forms of abuse, including verbal and physical. With the additional burdens of the pandemic including prolonged working hours, limited resources and insufficient humanitarian aid, the healthcare workers fall victim to increased levels of burnout and mental illnesses. The situation leads to dire consequences on their personal lives and professional development, compelling them to quit their job or country all together. Although healthcare workers remain resilient in these conflict‐based settings, immediate interventions are required to prevent violence against them and cater to their rapidly declining mental health.
Numerical simulation of heat and mass transfers radiative–convective fluid flow on a stretching porous surface with temperature‐dependent thermophysical properties
Authors: Omowaye A. J. , Falodun B. O. , Ahmed L. O. 
Published: November 2022

AbstractThis paper is focused on the analysis of heat and mass transfer radiative–convective fluid flow using quadratic multiple regression and numerical approach. The physical phenomenon is analyzed by utilizing partial differential equations (PDEs). Thermophysical properties, such as viscosity, thermal conductivity, and mass diffusivity, are varied and temperature‐dependent. This study is unique because of its applications in magnetohydrodynamic power accelerators, drilling operators, and bioengineering. The governing PDEs are transformed into coupled nonlinear ordinary differential equations (ODEs). The transformed ODEs are solved numerically using the spectral homotopy analysis method. Also, a quadratic multiple regression analysis is performed on quantities of engineering interest to show the significance of the flow parameters. It is observed that the heat and mass transfer process is affected by nonlinear buoyancy impact. The Lorentz force produced by the imposed magnetic field decline the thickness of the hydrodynamic boundary layer. Findings revealed that the nonlinear convective parameter and variable thermophysical properties are greatly affected by the rate of heat and mass transfer. Previously published work was used to validate the present one, which conformed with it. The slope of linear regression through data points is adopted to show the rate of change in skin friction, Nusselt, and Sherwood numbers during the flow phenomenon.
Etanercept alleviates psoriasis by reducing the Th17/Treg ratio and promoting M2 polarization of macrophages
Authors: Li Xiaoqing , Jiang Ming , Chen Xia , Sun Weiguo 
Published: November 2022

AbstractIntroductionThis study aimed to investigate the effect of etanercept in psoriasis and its underlying mechanism.MethodsFemale mice were treated with imiquimod (IMQ) to induce psoriasis, and intraperitoneally administered etanercept (0.1–0.4 mg/ml). The RAW264.7 cells were treated with LPS and IFN‐γ to polarize to M1, and were treated with IL‐13 and IL‐4 to polarize to M2.ResultsIn our study, Etanercept markedly reduced the psoriasis area and severity index scores, and epidermal thickness of mice induced by IMQ. In addition, etanercept reduced the levels of TNF‐α and IL‐6/12/23, and enhanced the levels of IL‐4/10, reduced Th17/Treg ratio and facilitated the polarization of macrophages to M2 in psoriasis model mice. Furthermore, etanercept inhibited the JAK/STAT3 pathway and increased the protein levels of SOCS1 and SOCS3.ConclusionsIn conclusion, our findings indicated that etanercept could inhibit the JAK/STAT3 pathway to reduce Th17/Treg ratio and promote M2 polarization, thereby alleviating psoriasis of mice.
Pagetoid spread of urothelial carcinoma controlled without resection
Authors: Yamamoto Shutaro , Shimomura Tatsuya , Kasai Kanako , Yamazaki Taisuke , Enei Yuki , Koike Yusuke , Ito Toshihiro , Harada Tohru , Furuta Nozomu , Kimura Takahiro 
Published: November 2022

IntroductionExtramammary Paget's disease is an eczematous skin condition that affects the vulva and perineum. Extramammary Paget's disease secondary to urothelial carcinoma is a rare condition that is typically treated with invasive surgical resection of the lesion.Case presentationAn 80‐year‐old woman with a 7‐year history of urothelial carcinoma presented with erythema of the labia majora. Immunostaining of skin biopsy specimens suggested extramammary Paget's disease secondary to urothelial carcinoma. The patient did not consent to resection of the lesion. Nine cycles of first‐line platinum‐based chemotherapy for metastatic urothelial carcinoma were administered. As tumor cells remained after systemic chemotherapy, pembrolizumab will be administered to the patient for treating residual extramammary Paget's disease.ConclusionPlatinum‐based chemotherapy can control extramammary Paget's disease secondary to urothelial carcinoma.
Cigarette smoke interacts with amiodarone toxicity in Saccharomyces cerevisiae
Authors: Al‐Attrache Houssein , Halloum Iman , Hammoud Lara , El Ghoz Katia , Abdel‐Razzak Ziad 
Published: November 2022

AbstractAmiodarone (AMD) is an antiarrhythmic drug prescribed to treat ventricular tachycardia and fibrillation. However, it causes an unpredictable toxicity (idiosyncratic), which may depend on co‐exposure to pollutants. AMD toxicity involves calcium homeostasis alteration and oxidative stress, which are also affected by cigarette smoke (CS). We investigated the interaction of CS‐condensate (CSC), phenanthrene, and benzo(a)pyrene with AMD toxicity on Saccharomyces cerevisiae. AMD toxicity was reduced by CSC or phenanthrene. Benzo(a)pyrene mildly decreased AMD toxicity on the wild‐type strain, but not on the catalase‐CTT1 mutant. This latter and other mutants in glucose receptor‐GPR1 or calcium transporter‐PMR1 showed lower antagonistic effect to AMD by CSC or phenanthrene relative to the wild type, suggesting roles of oxidative stress, calcium homeostasis, and hexose‐sensing in this interaction.
Identification of a Functional Susceptibility Variant for Adolescent Idiopathic Scoliosis that Upregulates Early Growth Response 1 (EGR1)-Mediated UNCX Expression
Authors: Yonezawa Yoshiro , Guo Long , Kakinuma Hisaya , Otomo Nao , Yoshino Soichiro , Takeda Kazuki , Nakajima Masahiro , Shiraki Toshiyuki , Ogura Yoji , Takahashi Yohei , Koike Yoshinao , Minami Shohei , Uno Koki , Kawakami Noriaki , Ito Manabu , Yonezawa Ikuho , Watanabe Kei , Kaito Takashi , Yanagida Haruhisa , Taneichi Hiroshi , Harimaya Katsumi , Taniguchi Yuki , Shigematsu Hideki , Iida Takahiro , Demura Satoru , Sugawara Ryo , Fujita Nobuyuki , Yagi Mitsuru , Okada Eijiro , Hosogane Naobumi , Kono Katsuki , Chiba Kazuhiro , Kotani Toshiaki , Sakuma Tsuyoshi , Akazawa Tsutomu , Suzuki Teppei , Nishida Kotaro , Kakutani Kenichiro , Tsuji Taichi , Sudo Hideki , Iwata Akira , Sato Tatsuya , Inami Satoshi , Nakamura Masaya , Matsumoto Morio , Terao Chikashi , Watanabe Kota , Okamoto Hitoshi , Ikegawa Shiro 
Published: November 2022

ABSTRACT
Adolescent idiopathic scoliosis (AIS) is a serious health problem affecting 3% of live births all over the world. Many loci associated with AIS have been identified by previous genome wide association studies, but their biological implication remains mostly unclear. In this study, we evaluated the AIS-associated variants in the 7p22.3 locus by combining in silico, in vitro, and in vivo analyses. rs78148157 was located in an enhancer of UNCX, a homeobox gene and its risk allele upregulated the UNCX expression. A transcription factor, early growth response 1 (EGR1), transactivated the rs78148157-located enhancer and showed a higher binding affinity for the risk allele of rs78148157. Furthermore, zebrafish larvae with UNCX messenger RNA (mRNA) injection developed body curvature and defective neurogenesis in a dose-dependent manner. rs78148157 confers the genetic susceptibility to AIS by enhancing the EGR1-regulated UNCX expression. © 2022 American Society for Bone and Mineral Research (ASBMR).
Exploring the relationship between corporate governance and firm's performance: Does political connection matter?
Authors: Almarayeh Taha , Tahtamouni Asem , Al‐Hamadeen Radhi , Alaodat Hamza , Alsoboa Sliman 
Published: November 2022

AbstractThe purpose of this research is to investigate the influence of corporate board and audit committee characteristics on firm performance as measured by accounting‐based ratios (earnings per share, return on asset, and return on equity) as well as the market‐based measure (Tobin's Q). In addition, this research introduces political connections to examine whether it can moderate the relationship between corporate board characteristics and firm performance. The study reveals that a higher proportion of independent directors and CEO duality positively affected firm performance. However, board meetings and board financial experience have no affected firm performance. The study also shows that audit committee independence, audit committee size, and audit committee expertise are positively related to firm performance. In contrast, it finds no discernible impact of audit committee meetings on firm performance. Our findings also suggest that the beneficial influences of the corporate board, in terms of higher firm performance, are greater in firms with political connections. To the best of the researchers’ knowledge, this is almost certainly the first analysis to examine the relation between the corporate board, audit committee characteristics, and firm performance, and the moderating effect of political connection of this relationship.
Does walking during chemotherapy impact p16INK4a levels in women with early breast cancer
Authors: Kammire Maria S. , Deal Allison M. , Damone Emily M. , Rosen Vanessa , Nyrop Kirsten A. , Mitin Natalia , Muss Hyman B. 
Published: November 2022

AbstractBackgroundIncreased p16INK4a (p16) expression is directly related to cellular senescence and is a robust biomarker of aging in humans. Prior studies have shown that levels of p16 dramatically increase in breast cancer patients who have received adjuvant chemotherapy. This study investigated whether moderate physical activity during chemotherapy would attenuate the expected rise in p16 expression.MethodsParticipants were women with Stage I–III breast cancer enrolled in a walking study for the duration of their chemotherapy (NCT02167932, NCT02328313, NCT03761706). Participants were asked to walk at least 30 min or 6200 steps/day following a structured walking program and to wear an activity tracker. p16 mRNA levels were measured in peripheral blood T‐cells before chemotherapy initiation and at approximately 6 months after last chemotherapy treatment (mean 200 days, SD 40 days).ResultsIn total, 141 participants met inclusion criteria and 10% (n = 14) averaged > 6200 steps/day. There was no significant association of daily steps with change in p16 levels pre‐ to post‐chemotherapy (Pearson correlation coefficient = 0.11, p = 0.17). After adjusting for age, stage, anthracycline‐based chemotherapy, and baseline p16, the change in log2 p16 for each 1000 steps was estimated to be 0.03 (p = 0.35). Most participants were sedentary prior to chemotherapy and achieved modest levels of physical activity during treatment.ConclusionA self‐guided walking program achieved only modest levels of physical activity and was unable to ameliorate chemotherapy‐induced change in p16 levels in women undergoing chemotherapy for early‐stage breast cancer. More structured and vigorous exercise programs should be tested for a more definitive exploration of their impact on post‐chemotherapy p16 levels.