bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of the nutritional status on facial morphology in young Japanese women
Authors: Tanikawa Chihiro , Kurata Miki , Tanizaki Noriko , Takeuchi Mika , Zere Edlira , Fukuo Keisuke , Takada Kenji 
Published: November 2022

AbstractEvidence regarding the possible influence of nutritional status on the facial morphology has thus far been insufficient. We examined whether or not the physical body compositions and dietary behaviors were correlated with any morphological characteristics of the face. One hundred and fifteen young Japanese women participated. Variables representing the dietary behaviors were extracted from self-reported survey data, and corresponding three-dimensional (3D) facial images and body compositions were examined. Multivariate analyses identified significant relationships between the nutritional status and facial topography (p < 0.05). The clustering method revealed the existence of three dietary condition patterns (“balanced diet”, “high-calorie-diet” with obesity tendency, and “imbalanced low-calorie-diet” with sarcopenic obesity tendency). Among these three patterns, a round face (increased facial width; analysis of variance [ANOVA], p < 0.05) was observed in the high-calorie-diet pattern, while the imbalanced low-calorie-diet pattern showed a more masculine face (increased face height, decreased eye height, increased non-allometric sexual shape differences; ANOVA, p < 0.05), thus suggesting the possibility of sex-hormonal influences. In summary, the body composition and dietary behaviors were found to influence the facial morphology, and potential biological influences were discussed.
Numerical simulation and experimental research on mechanical behaviour of hydraulic disc brakes based on multi-body dynamics
Authors: Zhang Wenyue , Zhao Cunbao , Chen Pengyu , Chen Enli , Lei Tianyu 
Published: November 2022

AbstractAs a vital road construction machine, the bridge erecting machine works in a very complex environment. The brake as an important link to maintain the safety and stability of the bridge erecting machine, it will have serious consequences if it is failed. Establishing the brake simulation model and specifying the fault characteristics according to the actual operation status will make it more efficient to find the cause of faults and maintain the safety of machine for a long time. A simulation model of brake of the bridge erecting machine was established by Adams. The brake arms and center axis with obvious data characteristics were flexibly processed, and finite elements were analysed using Abaqus. To verify the accuracy of simulation models, rectangular rosettes were applied to special geometric points, and the strain data were gathered by using the DH3816N collector and compared with the simulation model. The Adams kinematic simulation model was used to simulate the actual operating conditions by the experiment of the disc springs. Two typical fault phenomena were selected: reduced insufficient of disc spring and oil pressure, and two fault characteristics were extracted: variation of the brake shoe clearance and variation of the braking system pressure. When the brake generates the fault characteristics, the normal operation of the brake will not be affected if the fault characteristics are in the first stage. When the fault characteristics are beyond the critical threshold, the faults phenomena of the brake are generated. The results of the simulation experiments proved that the method of using the simulation model to extract the fault characteristics of the braking system and distinguish the causes of the fault was feasible.
Protection of insect neurons by erythropoietin/CRLF3-mediated regulation of pro-apoptotic acetylcholinesterase
Authors: Knorr Debbra Y. , Schneider Kristin , Büschgens Luca , Förster Jan , Georges Nadine S. , Geurten Bart R. H. , Heinrich Ralf 
Published: November 2022

AbstractCytokine receptor-like factor 3 (CRLF3) is a conserved but largely uncharacterized orphan cytokine receptor of eumetazoan animals. CRLF3-mediated neuroprotection in insects can be stimulated with human erythropoietin. To identify mechanisms of CRLF3-mediated neuroprotection we studied the expression and proapoptotic function of acetylcholinesterase in insect neurons. We exposed primary brain neurons from Tribolium castaneum to apoptogenic stimuli and dsRNA to interfere with acetylcholinesterase gene expression and compared survival and acetylcholinesterase expression in the presence or absence of the CRLF3 ligand erythropoietin. Hypoxia increased apoptotic cell death and expression of both acetylcholinesterase-coding genes ace-1 and ace-2. Both ace genes give rise to single transcripts in normal and apoptogenic conditions. Pharmacological inhibition of acetylcholinesterases and RNAi-mediated knockdown of either ace-1 or ace-2 expression prevented hypoxia-induced apoptosis. Activation of CRLF3 with protective concentrations of erythropoietin prevented the increased expression of acetylcholinesterase with larger impact on ace-1 than on ace-2. In contrast, high concentrations of erythropoietin that cause neuronal death induced ace-1 expression and hence promoted apoptosis. Our study confirms the general proapoptotic function of AChE, assigns a role of both ace-1 and ace-2 in the regulation of apoptotic death and identifies the erythropoietin/CRLF3-mediated prevention of enhanced acetylcholinesterase expression under apoptogenic conditions as neuroprotective mechanism.
Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU
Authors: Bychinin Mikhail V. , Klypa Tatiana V. , Mandel Irina A. , Yusubalieva Gaukhar M. , Baklaushev Vladimir P. , Kolyshkina Nadezhda A. , Troitsky Aleksandr V. 
Published: November 2022

AbstractVitamin D as an immunomodulator has not been studied in patients with severe COVID-19. This study aimed to estimate the efficacy of vitamin D3 supplementation on cellular immunity and inflammatory markers in patients with COVID-19 admitted to the intensive care unit (ICU). A single-center, double-blind, randomized, placebo-controlled pilot trial was conducted (N = 110). Patients were randomly assigned to receive a weekly oral dose of 60,000 IU of vitamin D3 followed by daily maintenance doses of 5000 IU (n = 55) or placebo (n = 55). Primary outcomes were lymphocyte counts, natural killer (NK) and natural killer T (NKT) cell counts, neutrophil-to-lymphocyte ratio (NLR), and serum levels of inflammatory markers on 7th day of treatment. On day 7, patients in the vitamin D3 group displayed significantly higher NK and NKT cell counts and NLR than those in the placebo group did. The mortality rate (37% vs 50%, P = 0.16), need for mechanical ventilation (63% vs 69%, P = 0.58), incidence of nosocomial infection (60% vs 41%, P = 0.05) did not significantly differ between groups. Vitamin D3 supplementation, compared with placebo, significantly increased lymphocyte counts, but did not translate into reduced mortality in ICU.Trial Registration: ClinicalTrials.gov Identifier: NCT05092698.
Continuous spark plasma synthesis of Au/Co binary nanoparticles with tunable properties
Authors: Villy Lajos Péter , Kohut Attila , Kéri Albert , Bélteki Ádám , Radnóczi György , Fogarassy Zsolt , Radnóczi György Zoltán , Galbács Gábor , Geretovszky Zsolt 
Published: November 2022

AbstractWe present here a scalable and environmentally friendly gas phase technique employing atmospheric pressure electrical spark discharge plasmas for the production of Au/Co binaries, an effective catalyst system for the decomposition of hydrogen-rich compounds, such as ammonium borane. We demonstrate that Au/Co alloy nanoparticles can be produced via the spark plasma-based technique. The possibility of varying the morphology and phase structure via real time heat treatment of the generated aerosol to form Au/Co/CoO particles with continuous control over a wide particle compositional range (from 24 to 64 at.% [Co]/([Co] + [Au]) content) is also demonstrated. Since our spark-based approach is proven to be capable of providing reasonable particle yields, these results may contribute to the transition of lab-scale, nanocatalyst-based hydrogen storage systems to real world applications.
Synthesis, characterization, and radiosynthesis of fluorine-18-AVT-011 as a Pgp chemoresistance imaging marker
Authors: Kumar Pardeep , Thakur Riptee , Acharya Pratap Chandra , Mohan Hosahalli K. , Pallavi U. N. , Maheshwari Divya , Mohammed K M Afsal , Kumar Aishwarya , Goud Nerella Sridhar , Joshi Raman Kumar , Kumar Manoj , Nagaraj Chandana 
Published: November 2022

AbstractP-glycoprotein (Pgp) is the most studied ATP-binding cassette (ABC) efflux transporter and contributes to chemoresistance. A few tracers have been developed to detect the in-vivo status of chemoresistance using positron emission tomography (PET) imaging. In our study, we have synthesized labeled AVT-011 with fluorine-18 (18F) followed by in-vitro and in-vivo analysis. Tosylate AVT-011 precursor was synthesized and characterized by 1H-NMR and 13C-NMR. AVT-011 was labeled with 18F using the nucleophilic substitution method, and a standard set of quality control was performed. The specificity for Pgp was tested in U87MG cells with and without an inhibitor (tariquidar). The biodistribution and in-vivo stability were tested in the small animals (mice). The biodistribution data of [18F]-AVT-011 was extracted from the PET-CT imaging of breast cancer patients (n = 6). The precursor was synthesized with 36 ± 4% yield and 97 ± 2% purity. The labeling was more than 95% with a 42 ± 2% yield, as evaluated by Radio-HPLC. The cell-binding assay showed a specificity of the tracer for Pgp as the uptake increased by twice after blocking the Pgp receptors. The radiotracer showed a hepatorenal excretion pathway for clearance in an animal study. The uptake was higher in the liver, lungs, spleen, and heart at 15 min and decreased at 60 min. The patients' distribution showed similar uptake patterns as observed in the small animals. [18F]AVT-011 was characterized successfully with high radiochemical purity and yield. The in-vitro and in-vivo studies proved its specificity for Pgp and safe for patient use.
Evaluating the quality of care for postpartum hemorrhage with a new quantitative tool: a population-based study
Authors: Didelot Hélène , Goffinet François , Seco Aurélien , Deneux-Tharaux Catherine ,   The EPIMOMS (EPIdémiologie de la MOrbidité Maternelle Sévère) Study Group, Azria Elie , Baunot Nathalie , Beucher Gaël , Bonnet Marie-Pierre , Bouvier-Colle Marie-Hélène , Carbillon Lionel , Chantry Anne , Chiesa-Dubruille Coralie , Crenn-Hebert Catherine , Deneux-Tharaux Catherine , Dupont Corinne , Fresson Jeanne , Kayem Gilles , Langer Bruno , Mignon Alexandre , Rozenberg Patrick , Rudigoz René-Charles , Seco Aurélien , Touzet Sandrine , Vendittelli Françoise 
Published: November 2022

AbstractTo develop a new tool to assess the global quality of care for post-partum hemorrhage (PPH)—the leading preventable cause of maternal mortality worldwide—and to identify characteristics of maternity units associated with inadequate PPH management. This is a secondary analysis of the EPIMOMS population-based study conducted in 2012–2013 in 119 french maternity units (182,309 women who gave birth). We included women with severe PPH. We first developed a score to quantify the quality of care for PPH. Then, we identified characteristics of the maternity units associated with “inadequate care” defined by a score below the 25th percentile, with multi-level logistic regression adjusted for individual characteristics. The score combined 8 key components of care and took into account delivery mode and PPH cause. For PPH after vaginal delivery, the risk of inadequate care was increased in low versus high-volume maternity units (< 1000 deliveries/year: aOR-2.20 [1.12–4.32], [1000–2000 [deliveries/year: aOR-1.90 [1.02–3.56] compared to ≥ 3500 deliveries/year), in private versus public units (aOR-1.72 [1.00–2.97]), and in low versus high-level of care units (aOR-2.04 [1.24–3.35]). For PPH after cesarean, the only characteristic associated with an increased risk of inadequate care was the absence of 24/24-onsite anesthesiologist (aOR-4.34 [1.41–13.31]). These results indicate where opportunities for improvement are the greatest.
Construction and validation of web-based nomograms for detecting and prognosticating in prostate adenocarcinoma with bone metastasis
Authors: Dong Qiu , Wu Xiaoting , Gan Wenyi , MOK Tsz Ngai , Shen Juan , Zha Zhengang , Chen Junyuan 
Published: November 2022

AbstractBone metastasis (BM) is one of the most common sites of metastasis in prostate adenocarcinoma (PA). PA with BM can significantly diminish patients’ quality of life and result in a poor prognosis. The objective of this study was to establish two web-based nomograms to estimate the risk and prognosis of BM in PA patients. From the Surveillance, Epidemiology, and End Results (SEER) database, data on 308,332 patients diagnosed with PA were retrieved retrospectively. Logistic and Cox regression, respectively, were used to determine independent risk and prognostic factors. Then, We constructed two web-based nomograms and the results were validated by receiver operating characteristic (ROC) curves, calibration curves, decision curve analysis (DCA) , and the Kaplan-Meier analyses. The independent risk factors for BM in PA patients included race, PSA, ISUP, T stage, N stage, brain, liver, lung metastasis, surgery, radiation and chemotherapy. The independent prognostic predictors for overall survival (OS) were age, marital status, PSA, ISUP and liver metastasis. Both nomograms could effectively predict risk and prognosis of BM in PA patients according to the results of ROC curves, calibration, and DCA in the training and validation sets. And the Kaplan-Meier analysis illustrated that the prognostic nomogram could significantly distinguish the population with different survival risks. We successfully constructed the two web-based nomograms for predicting the incidence of BM and the prognosis of PA patients with BM, which may assist clinicians in optimizing the establishment of individualized treatment programs and enhancing patients’ prognoses.
The association between pre-gravid and first trimester maternal weight and its implications for clinical research studies
Authors: Retnakaran Ravi , Ye Chang , Wen Shi Wu , Tan Hongzhuan 
Published: November 2022

AbstractIn clinical research, weight measurement in first trimester is often treated as a surrogate for pre-pregnancy weight. The validity of this critical assumption, however, is uncertain. Thus, we sought to prospectively evaluate the relationship between pre-gravid weight and first trimester weight. In this prospective preconception observational cohort study, 474 newly-married women in Liuyang, China, underwent pre-gravid evaluation at median 17.7 weeks before a singleton pregnancy, during which they had weight measurement in first trimester. The relationship between pre-gravid and first trimester weight was assessed by Bland–Altman analysis, Concordance Correlation Coefficient, and Pearson correlation. Mean pre-gravid weight was 49.8 ± 6.4 kg and mean weight in first trimester was 51.1 ± 7.0 kg. The Concordance Correlation Coefficient between pre-gravid and first trimester weight was 0.76 (95% limits of agreement: 0.72–0.80) and Pearson correlation was r = 0.78 (p < 0.0001), indicative of good concordance and correlation. As the timing of the weight measurement in first trimester increased in weekly increments from < 8 weeks to 14 weeks, the Concordance Correlation Coefficient ranged between 0.69 to 0.76 and the Pearson correlation ranged from 0.71 to 0.78 (allp < 0.0001). In conclusion, the observed concordance between pre-gravid weight and weight measured at any point in the first trimester provides a measure of validation for the widespread practice in clinical research of treating first trimester weight measurement as a surrogate for maternal weight before pregnancy.
Effects of prolonged working hours on heart rate variability in internal medicine physicians
Authors: Nantsupawat Teerapat , Tungsuk Pongsatorn , Gunaparn Siriluck , Phrommintikul Arintaya , Wongcharoen Wanwarang 
Published: November 2022

AbstractPrior studies have utilized heart rate variability (HRV) as the assessment tools for psychological and physiological stress during 24-h shift. However, data regarding effects of prolonged working hours > 24 h on HRV are limited. We aimed to compare between pre- and post-call HRV among physicians who worked 24 plus 8 h. The study included 60 physicians in the internal medicine training. All subjects underwent Holter ECG monitoring for HRV assessment. We compared between HRV of an 8-h regular workday (8am to 4 pm) before on-call duty (pre-call HRV) and an 8-h workday after 24-h on-call duty (post-call HRV). The mean age was 26 ± 2.5 years. Mean total sleep time during on-call duty was 238.9 ± 88.3 min. In overall population, the time-domain and frequency-domain HRV parameters were not different between pre- and post-call day. However, the physicians reported their sleep time in the 1st quartile (< 180 min) had significant increase in SDNN, pNN50, high frequency (HF), and decrease in low/high frequency ratio (LF/HF). In contrast, the physicians reported their sleep time in the 4th quartile (> 307.5 min) had significant decrease in pNN50, LF, HF, and increase in heart rate. Multiple linear regression revealed total sleep time as an independent factor associated with pre- and post-call HRV alterations. More sleep during on call (> 5 h) was associated with HRV pattern suggesting both increased sympathetic activity and reduced parasympathetic activity, while less sleep (< 3 h) during on call was associated with post-call parasympathetic rebound HRV pattern.
Accuracy, interpretability and usability study of a wireless self-guided fetal heartbeat monitor compared to cardiotocography
Authors: Porter Paul , Zhou Huaqiong , Schneider Brooke , Choveaux Jennifer , Bear Natasha , Della Phillip , Jones Kym 
Published: November 2022

AbstractFetal Cardiography is usually performed using in-hospital Cardiotocographic (CTG) devices to assess fetal wellbeing. New technologies may permit home-based, self-administered examinations. We compared the accuracy, clinical interpretability, and user experience of a patient-administered, wireless, fetal heartbeat monitor (HBM) designed for home use, to CTG. Initially, participants had paired HBM and CTG examinations performed in the clinic. Women then used the HBM unsupervised and rated the experience. Sixty-three women had paired clinic-based HBM and CTG recordings, providing 6982 fetal heart rate measures for point-to-point comparison from 126 min of continuous recording. The accuracy of the HBM was excellent, with limits of agreement (95%) for mean fetal heart rate (FHR) between 0.72 and −1.78 beats per minute. The FHR was detected on all occasions and confirmed to be different from the maternal heart rate. Both methods were equally interpretable by Obstetricians, and had similar signal loss ratios. Thirty-four (100%) women successfully detected the FHR and obtained clinically useful cardiographic data using the device at home unsupervised. They achieved the required length of recording required for non-stress test analysis. The monitor ranked in the 96–100th percentile for usability and learnability. The HBM is as accurate as gold-standard CTG, and provides equivalent clinical information enabling use in non-stress test analyses conducted outside of hospitals. It is usable by expectant mothers with minimal training.
ATP-binding and hydrolysis of human NLRP3
Authors: Brinkschulte Rebecca , Fußhöller David M. , Hoss Florian , Rodríguez-Alcázar Juan F. , Lauterbach Mario A. , Kolbe Carl-Christian , Rauen Melanie , Ince Semra , Herrmann Christian , Latz Eicke , Geyer Matthias 
Published: November 2022

AbstractThe innate immune system uses inflammasomal proteins to recognize danger signals and fight invading pathogens. NLRP3, a multidomain protein belonging to the family of STAND ATPases, is characterized by its central nucleotide-binding NACHT domain. The incorporation of ATP is thought to correlate with large conformational changes in NLRP3, leading to an active state of the sensory protein. Here we analyze the intrinsic ATP hydrolysis activity of recombinant NLRP3 by reverse phase HPLC. Wild-type NLRP3 appears in two different conformational states that exhibit an approximately fourteen-fold different hydrolysis activity in accordance with an inactive, autoinhibited state and an open, active state. The impact of canonical residues in the nucleotide binding site as the Walker A and B motifs and sensor 1 and 2 is analyzed by site directed mutagenesis. Cellular experiments show that reduced NLRP3 hydrolysis activity correlates with higher ASC specking after inflammation stimulation. Addition of the kinase NEK7 does not change the hydrolysis activity of NLRP3. Our data provide a comprehensive view on the function of conserved residues in the nucleotide-binding site of NLRP3 and the correlation of ATP hydrolysis with inflammasome activity.
A systematic scoping review of the sustainability of vertical farming, plant-based alternatives, food delivery services and blockchain in food systems
Authors: Bunge A. Charlotte , Wood Amanda , Halloran Afton , Gordon Line J. 
Published: November 2022

AbstractFood system technologies (FSTs) are being developed to accelerate the transformation towards sustainable food systems. Here we conducted a systematic scoping review that accounts for multiple dimensions of sustainability to describe the extent, range and nature of peer-reviewed literature that assesses the sustainability performance of four FSTs: plant-based alternatives, vertical farming, food deliveries and blockchain technology. Included literature had a dominant focus on environmental sustainability and less on public health and socio-economic sustainability. Gaps in the literature include empirical assessments on the sustainability of blockchain technology, plant-based seafood alternatives, public health consequences of food deliveries and socio-economic consequences of vertical farming. The development of a holistic sustainability assessment framework that demonstrates the impact of deploying FSTs is needed to guide investments in and the development of sustainable food innovation.
Crowdsourcing bridge dynamic monitoring with smartphone vehicle trips
Authors: Matarazzo Thomas J. , Kondor Dániel , Milardo Sebastiano , Eshkevari Soheil S. , Santi Paolo , Pakzad Shamim N. , Buehler Markus J. , Ratti Carlo 
Published: November 2022

AbstractMonitoring and managing the structural health of bridges requires expensive specialized sensor networks. In the past decade, researchers predicted that cheap ubiquitous mobile sensors would revolutionize infrastructure maintenance; yet extracting useful information in the field with sufficient precision remains challenging. Herein we report the accurate determination of critical physical properties, modal frequencies, of two real bridges from everyday vehicle trip data. We collected smartphone data from controlled field experiments and uncontrolled Uber rides on a long-span suspension bridge in the USA (The Golden Gate Bridge) and developed an analytical method to accurately recover modal properties. We also successfully applied the method to partially-controlled crowdsourced data collected on a short-span highway bridge in Italy. Further analysis projected that the inclusion of crowdsourced data in a maintenance plan for a new bridge could add over fourteen years of service (30% increase) without additional costs. Our results suggest that massive and inexpensive datasets collected by smartphones could play a role in monitoring the health of existing transportation infrastructure.