bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obstacles to The Application of Total Quality Management in The Administrative Aspects of The Colleges of Education in The Palestinian Universities
Authors: EL-Khaeir Ahmed Ghoneem Abu 
Published: August 2022

Abstract The present study aimed to identify the obstacles to the application of TQM in the administrative aspects of the colleges of education in Palestinian universities. The study used descriptive analytical approach and relied on the questionnaire included the following areas (preparation, planning, Organization, , implementation, control, and evaluate the quality). The study population consisted of faculty members and officials, academics and administrators in colleges of education universities in the Gaza Strip (Al- Quds open , Palestine, Al-Aqsa) The study found that there are a significant proportion of the obstacles in the implementation phases of TQM at colleges of education in the Palestinian universities, which accounted for (77.14). There were more obstacles in the implementation of QM procedures, the main obstacles that have emerged in the results of the study are: the absence of method of work as a team and forming quality loops. And the limited number of meetings and seminars to educate the workers necessary quality system. The study found that there were no statistically significant differences for the most important obstacles facing the implementation of TQM at colleges of education departments in Palestinian universities due to the variable Job Title differences. As it turns out there are statistically significant differences between the averages of the study sample estimates of the most important obstacles facing the implementation of TQM attributed to the university in favor of Al-Aqsa University. The study recommended the need to increase the number of required meetings and seminars to educate the workers. to encourage the style of work as a team and the formation of QCs quality system
Computer aided semen analysis (CASA) to determine the quality and fertility of frozen thawed sumba ongole sperm supplemented with amino acids
Authors: Maulana Tulus , Agung Paskah Partogi , Gunawan Muhammad , Said Syahruddin 
Published: August 2022

<p><strong>Objective</strong>: The objective of this research was to investigate the quality and reproductive potential of frozen-thawed Sumba Ongole (SO) bull spermatozoa supplemented with specified amino acids using computer-assisted semen analysis (CASA).</p><p><strong>Methods</strong>: A total of 18 ejaculates were collected once a week from three Sumba Ongole bulls and diluted in tris-citric-fructose-egg yolk (TCFY) extender and various concentrations of selected amino acids. The post-thaw spermatozoa were examined for motility, head behavior, and swimming pattern using CASA technique. Data were analysis using SPSS 24 ebvaluated by ANOVA.</p><p><strong>Results</strong>: Total motility (72.56%±3.20) and progressive motility (71.11%±3.31) the addition of Glutamine 5% significantly different (p&lt;0.05) than other treatments. The addition of 7mM cysteine resulted in significantly (p&lt;0.05) in velocity average path (VAP), velocity curve line (VCL), velocity straight line(VSL) parameters also have higher in distance average path (DAP), distance curve line (DCL), dan distance straight line (DSL) parameters significantly (p&lt;0,05). </p><p><strong>Conclusion</strong>: In conclusion, the introduction of CASA systems enabled quantification of individual spermatozoa motility patterns and CASA colud be used to estimate the fertilizing capacity of sperm based on the characteristics of sperm velocity.</p>
Automatic Measurement of the Dependence on Pressure and Temperature of the Mass Density of Drilling Fluids
Authors: Cayeux E. 
Published: August 2022

Summary
Drilling fluids are subject to substantial variations in pressure and temperature while they are circulated in a well. These changes are so great that the mass density of the drilling fluid varies significantly during circulation. Accurate estimation of the hydrostatic and hydrodynamic pressures therefore requires a reliable model of the pressure and temperature dependence of the mass density of the drilling fluid. Usually, the mass density of a drilling fluid is measured manually with a mud balance. The pressure and temperature dependence of the mass density of the fluid [i.e., its pressure, volume, and temperature (PVT) behavior] is then calculated from a PVT model of its components and their relative proportions. However, variations in the composition of the fluid mix and uncertainties in the PVT behavior of each component may lead to inaccuracies. To overcome these limitations, an apparatus has been designed to measure the PVT behavior of the drilling fluid directly and automatically. The setup measures both the mass density and the speed of sound of the fluid at specific conditions of pressure and temperature. It is possible to estimate the adiabatic compressibility from the speed of sound in the liquid mix. The device utilizes a heat exchanger from which the specific heat capacity of the drilling fluid can be derived. The isothermal compressibility can be calculated by combining the specific heat capacity and the adiabatic compressibility. While estimating the specific heat capacity using the heat exchanger, the thermal conductivity of the fluid is also estimated as a byproduct. A PVT model of the drilling fluid is obtained by combining measurements made at different conditions of pressure and temperature. The automatic and continuous provision of drilling fluid PVT behavior enhances the precision of model predictive drilling control systems and, at the same time, can simplify their configuration, therefore making them more accessible to any drilling operation.
An Indirect Approach for Flow Pattern Transition Identification Inside a Low-Specific-Speed Centrifugal Pump with Experimental Verification and Theoretical Modeling
Authors: Li Yuanyuan , Zhu Jianjun , Zeng Hao , Zhang Yongxue , Lu Yingda , Fan Yilin , Zhu Haiwen 
Published: August 2022

Summary
Of significant importance to the multiphase flow, the gas/liquid two-phase flow patterns and the transition boundaries between them are extremely difficult to be characterized inside the centrifugal pumps because the steel-made nontransparent casing shrouds the impeller’s flow passages. How to visualize the internal flow patterns within the rotating impeller has drawn considerable attention. In this study, an indirect approach proposed by Gamboa and Prado (2011) to recognize the gas/liquid flow patterns in the centrifugal impeller via inflection characteristics of H-Q performance curves is used and verified by both experimental tests and numerical simulations. To further validate the indirect flow pattern recognition approach to a low-specific-speed centrifugal pump, the acrylic-made transparent impeller was adopted to conduct experimental testing, in which the internal two-phase flow pattern can be visualized by a high-speed camera. The 3D numerical simulation was performed and compared with corresponding visualization experiments to illustrate the two-phase flow structures. The preliminary results reveal that the inflection characteristics on the H-Q performance curves of the centrifugal pump can be regarded as the flow pattern transition boundaries under various flow conditions. The experiments and simulations conducted for this paper further validated an existing mechanistic model to predict flow pattern transitions.
Ranking the return on assets of Tehran stock exchange by a new method based on Z-numbers data
Authors: Farzam Maryam , kermani Mozhdeh Afshar , Allahviranloo Tofigh , Aminataei Azim 
Published: August 2022

Abstract

Since real-world data is often inaccurate and working with fuzzy data and Z-numbers arevery important and necessary, in the real world we need to rank and compare data. Inthis paper, we introduce a new method for ranking Z-numbers. This ranking algorithm isbased on centroid point.We evaluate distance between centroid point, and based on this distance, we rank theZ-numbers.We use this method in two practical examples. First in ranking the return on assets ofTehran stock exchange, and second, in ranking of factors affecting the productivity oftourism security.The advantage of this method over conventional fuzzy methods is considering uncertainty,and allocating credit in the opinion of experts to estimate fuzzy parameters.
Species Composition, Abundance, and Behavioral Patterns of Lizards in the Devanahalli Fort of the Bengaluru North City Region, Bengaluru, India
Authors: Rajashekara S. , Manu N. , Singh L. Kiran , Hemalatha A. S. , Lalruatkima L. , Lavanya M. , Madhuri A. V. , Harshith J. Sai , Shahziya S. , Shwetha H. E. , Sowmya R. , Prajwal Sri Sai , Purushothama D. V. 
Published: August 2022

Abstract
Species composition and abundance of lizard populations was studied in the historical monuments such as the Devanahalli fort of the Bengaluru North City region, Bengaluru, India. The quadrants laid in the fort was surveyed for the estimation of the population density, abundance, sex ratio, frequency and distribution of the lizards in the Devanahalli fort. A total of nine species of lizards were recorded during the study, thus highlighting the significance of historical forts in acting as important urban habitats for reptiles. The reptilian fauna of the historical monuments such as forts, temples and archeological sites were found to be more distinct than the rest of the urban landscapes. In addition to this, notes on the morphometric analysis, behavioral patterns and natural history of recorded lizards was observed. Therefore, the abundance of the lizard populations in the historical fort’s call for its special concern for care because their archeological importance and will be of use for urban planning and conservation.
Lymphovascular invasion represents a superior prognostic and predictive pathological factor of the duration of adjuvant chemotherapy for stage III colon cancer patients
Authors: Zhang Linjie , Deng Yuxiang , Liu Songran , Zhang Weili , Hong Zhigang , Lu Zhenhai , Pan Zhizhong , Wu Xiaojun , Peng Jianhong 
Published: August 2022

AbstractPurpose: Lymphovascular invasion (LVI) and perineural invasion (PNI) can indicate poor survival outcomes in colorectal cancer, but few studies have focused on stage III colon cancer. The current study aimed to confirm the prognostic value of LVI and PNI and identify patients who could benefit from a complete duration of adjuvant chemotherapy based on the two pathological factors.Methods: We enrolled 402 consecutive patients with stage III colon cancer who received colon tumor resection from November 2007 to June 2016 at Sun Yat-sen University Cancer Center. Survival analyses were performed by using Kaplan–Meier method with log-rank tests. Risk factors related to disease-free survival (DFS) and overall survival (OS) were identified through Cox proportional hazards analysis.Results: 141 (35.1%) patients presented with LVI, and 108 (26.9%) patients with PNI. The LVI-positive group was associated with poorer 3-year DFS (86.5% vs. 76.3%, P=0.001) and OS (96.0% vs. 89.1%, P=0.003) rates compared with the LVI-negative group. The PNI-positive group showed a worse survival outcome compared with the PNI-negative group in 3-year DFS rate (72.5% vs. 86.7%, P < 0.001). Moreover, LVI-positive group present better 3-year DFS and OS rate in patients completing 6–8 cycles of adjuvant chemotherapy than those less than 6 cycles (3-year DFS: 80.0% vs. 64.9%, P=0.019; 3-year OS: 93.2% vs. 76.3%, P = 0.002).Conclusions: LVI is a superior prognostic factor to PNI in stage III colon cancer patients undergoing curative treatment. Furthermore, LVI also represents an effective indicator for adjuvant chemotherapy duration.
Clinical features and forecast indexes of the disease severity of SARS-CoV-2: a retrospective cohort study comparing the wild-type strain and the Delta VOC
Authors: zhang hongjun , Chen Yue-e , Shang Fen-qing , Chen Yan-wei , Wang Rui-xuan , Zheng Wen-hao , Ma Tian-tian , Zhang Xiu-cheng , Li Wen-jie , Gu Xing 
Published: August 2022

Abstract
BackgroundA novel variant of SARS-CoV-2, the Delta variant of concern (VOC), on disease severity is very unclear. In this retrospective study, we compared the clinical characteristics and the outcomes of patients infected with the Delta VOC and with wild-type strains during the local outbreak in Xi'an and Wuhan, China.MethodsThe clinical information pertaining to the 2927 cases (between February 10 and March 8, 2020) infected with wild-type strains and the 993 cases (between December 22, 2021and February 17, 2022) infected with the Delta VOC were extracted. The clinical characteristics and outcomes were compared the cohort of wild-type infection with the cohort of Delta VOC.ResultsAmong patients younger than 18 years old, the proportion of patients infected with the Delta VOC was significantly higher than that of patients infected with wild-type strains (12.2% vs. 0.3%). In cases with mild and moderate illness, the proportion of patients was higher in the Delta VOC group than that in the wild-type strain (40.9% and 56.6% vs. 0.70% and 3.10%). However, in severe and critical patients, the proportion of patients was significantly less in the Delta VOC group than that in the wild-type strain (1.6% and 0.9% vs. 24.2% and 72.0%). In cases with severe or critical illness, and in the Delta VOC cohort or the wild-type cohort, the prognosis of patients with lymphocytes blood levels that gradually rising is good after treatment, while the prognosis of patients with lymphocytes blood levels that remain low is poor and even death(p<0.001). The Cox regression analysis revealed that the infection with the lineage of the wide-type strain had a higher risk than the Delta VOC in deteriorating to critical illness (hazards ratio 2.54[95%CI 1.279–5.026]; p = 0.008).ConclusionsUnder the two different anti-epidemic situations and anti-epidemic strategies, infection with the Delta VOC is characterized by younger patients, milder illness, and decreased risk of disease prognosis, compared with the SARS-CoV-2 wild-type lineage; lymphopenia is an effective predictor of deterioration in patients with Delta VOC and wild-type strains, calling for clinicians to understand of characteristics of them according to the different anti-epidemic situations and anti-epidemic strategies, and to guide clinical decision-making.
Zero Self-Harm app – a mobile phone application to reduce non-suicidal self-injury: Study protocol for a randomized controlled trial
Authors: Andreasson Kate , Larsen Lene , Buus Niels , Larsen Jette , Krogh Jesper , Thastum Rasmus , Guerrero Evelyn , Lindberg Lone , Lindblad Katrine , Erlangsen Annette , Nordentoft Merete 
Published: August 2022

Abstract
Background: Non-suicidal self-injury (NSSI) is a growing healthcare problem. Individuals with NSSI have an increased risk of suicidality. Because of stigma, they may self-injure in secret, which means they often seek help when events have escalated to suicidal ideation or a mental disorder. Previous studies have shown that interventions delivered via mobile phone applications have the potential to reduce self-injury. This protocol outlines a trial, which examines whether the Zero Self Harm-intervention, which is based on an app created for people with NSSI, can reduce the number of NSSI-episodes, suicide ideation, and depressive symptoms. Methods: The trial will be conducted as a 6-month 2-arm, parallel-group, multicentre, pragmatic, randomized clinical superiority trial. The intervention group will receive the app and instructions on how to use it, while the control group will be allocated to a waitlist and allowed to download the app after 6 months. Participants will be asked to complete questionnaires at 3- and 6 months after date of inclusion and the primary outcome is the number of NSSI-episodes during the last month, as measured at the 3 months follow-up with the Deliberate Self-Harm Inventory. A total of 280 participants, 140 in each arm, will be included.Discussion: This trial will assess the effectiveness of the Zero Self Harm-intervention to reduce the number of NSSI episodes. If effective, the app will have the potential to support to large group of people with NSSI. NSSI is stigmatised and often done in secret. Being both discreet and anonymous, the app might be an appealing option for support. In addition, people with current or former NSSI were involved in the development of the app. The app was developed with a focus on minimizing harm, not to end NSSI, which might also make the app appealing for a broader group of users.Trial registration: ClinicalTrials.gov, NCT04463654. Registered on 7 June 2020
Stochastic Modeling for Bandwidth Part Switching based DRX Mechanism in 5G NR Networks
Authors: Jain Vidyottama , Garg Nikita , Dharmaraja S. 
Published: August 2022

Abstract
The intensification of mobile broadband services and user experience is explicitly dependent on increased battery life of user equipment (UE) and minimized delay in service. In 5G New Radio (NR), in addition to Discontinuous Reception (DRX) scheme, Bandwidth Part (BWP) switching plays a significant role in reducing UE power consumption. The dynamic bandwidth operation in BWP switching is power efficient as UE can adapt its operating bandwidth based on the traffic arrival. In this work, BWP switching based DRX mechanism is modeled as an MX/G/ 1 queue to trade-off between quality of service (QoS) and power saving in UE in 5G NR. Analytical and numerical results on the proposed model show it to be promising in minimizing power consumption and reducing delay in service of UE.
Molecular intrinsic subtypes, genomic and immune landscapes of BRCA-proficient but HRD-high ER-positive/HER2-negative early breast cancers
Authors: Ballot Elise , Galland Loïck , Mananet Hugo , Boidot Romain , Arnould Laurent , Desmoulins Isabelle , Mayeur Didier , Kaderbhai Courèche , Ilie Silvia , Hennequin Audrey , Bergeron Anthony , Derangère Valentin , Ghiringhelli François , Truntzer Caroline , Ladoire Sylvain 
Published: August 2022

Abstract
Purpose: The vast majority of research studies that have described the links between DNA damage repair or homologous recombination deficiency (HRD) score, and tumor biology, have concerned either triple negative breast cancers or cancers with mutation of BRCA 1/2. We hypothesized that ER+/HER2- early breast tumors without BRCA 1/2 mutation could have high HRD score, and aimed to describe their genomic, transcriptomic, and immune landscapes.Patients and methods: In this study, we reported BRCA 1/2 mutational status, HRD score and mutational signature 3 (S3) expression, in all early breast cancer (eBC) subtypes from the TCGA database, with a particular focus in ER+/HER2-. In this subtype, bioinformatics analyses of tumor transcriptomic, immune profile, and mutational landscape, were performed, according to HRD status. Overall survival (OS), progression free-interval (PFI), and variables associated with outcome were also evaluated.Results: Among the 928 tumor samples analyzed, 46 harboured BRCA 1/2 mutations, 606 were ER+/HER2- (of which 24 were BRCA 1/2 mutated). We found a subset of BRCA-proficient ER+/HER2— eBC, with high HRD score. These tumors displayed significantly different immune, mutational, and tumor molecular signatures landscapes, compared to BRCA mutated and BRCA-proficient HRD-low tumors. Outcome did not significantly differ between these 3 groups, but biological factors associated with survival are not the same across the 3 entities.Conclusion: This study highlights possible novel biological differences among ER+/HER2- breast cancer related to HRD status. Our results could have important implications for translational research and/or the design of future clinical trials, but require prospective clinical evaluation.
Rhizosphere-induced shift in the composition of bacterial community favors mineralization of crop residue nitrogen
Authors: Zhihuang XIE , Yu Zhenhua , Li Yansheng , Wang Guanghua , Tang Caixian , Mathesius Ulrike , Liu Xiaobing , Liu Junjie , Liu Judong , Chen Yuan , Zhang Shaoqing , Herbert Stephen J , Wu Junjiang , Jin Jian 
Published: August 2022

Abstract
Aims In agricultural systems, residue amendment is an important practice for nutrient management, but it is not well known how the residue-nitrogen (N) mineralization is associated with changes of microbial community composition in the crop rhizosphere. Therefore, this study aimed to examine the role of microbes in crop residue N mineralization.Methods A rhizobox system was deployed to reveal the gradient change of the residue-N mineralization in the root-growth zone, and 2 mm and 4 mm away from the root of soybean. Plants were grown in a Mollisol without or with amendment of 15N-labelled soybean and maize residues. Furthermore, amplicon sequencing was performed to detect the shift of microbial community composition associated with the residue-N mineralization. Results The residue-N was mineralized faster in the rhizosphere than the bulk soil, and from soybean residue than maize residue. The co-occurrence network of N-mineralization associated community altered with the shift in the hubs. Moreover, greater enrichment of taxa against the unit of residue-N mineralization and more hubs in the network in the soybean than maize residue treatment were correspondent with the enriched ammonification genes, likely contributing to the enhanced mineralization of soybean residue-N in the rhizosphere. An increase in dissolved organic C and a decrease in available N concentration in the rhizosphere, relative to the bulk soil, might shift bacterial community favoring the residue-N mineralization. Conclusions The spatial changes in chemical properties across the rhizosphere lead to the recruitment of core microbiome taxa to enhance the mineralization of N derived from crop residues.
Bioinformatics analysis reveling prognostic roles of CDK1 in breast cancer
Authors: Zhao Hongfang , Zhang Lijian , Wang Hanbin , Ji Xiaolin , Li Chunhui 
Published: August 2022

Abstract
Background
The current treatment of breast cancer (BC) commonly adopts endocrine therapy and immunotherapy. And the acquired resistance to those therapies remains a major challenge. Recent evidences indicate that the alternation in tumor microenvironment is a critical factor for cancer therapeutic resistance. Thus, identification of genes that impact tumor micro-environment could contribute to early diagnosis of BC and development of potential therapeutic options.
Methods
In this study, 3 datasets were acquired from the GEO database to identify the differentially expressed genes (DEGs) between BC tissues and normal tissues. The GO functional and KEGG pathway enrichment of the DEGs were analyzed by using the DAVID database, followed by the construction of a protein-protein interaction (PPI) network. CytoHubba and MCODE were used to select hub genes. GEPIA, Kaplan-Meier Plotter, and UALCAN were used for key gene screening and investigating its effect on patients’ outcome.
Results
In total, 183 up-regulated and 85 down-regulated DEGs were identified. We identified 10 key genes, including CDK1, CEP55, CENPF, PRC1, TOP2A, NCAPG, KIF4A, CCNB1, ASPM, and KIF20A, and the expression of those genes was correlated well with overall survival of BC patients. Further, the expression level of CDK1 was positively correlated with macrophages, CD4 + T cells, CD8 + T cells and special MDSCs, and negatively correlated with CAFs cells.
Conclusions
Results of this study may reveal that CDK1 could influence clinicopathological parameters and immune micro-environment, especial immune cell infiltration including myeloid derived suppressor cells (MDSCs), which could serve as a prognostic biomarker in BC patients.