bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between industry support and the reporting of study outcomes in randomized clinical trials of dental implant research from the past 20 years
Authors: Dini Caroline , Pereira Marta Maria Alves , Souza João Gabriel Silva , Shibli Jamil A. , de Avila Erica Dorigatti , Barão Valentim Adelino R. 
Published: January 2022

AbstractBackgroundIndustry support is a significant funding source in implant dentistry research, not only to provide regulatory processes, but also to validate and promote products through randomized clinical trials (RCTs). However, industry funding should not affect scientific outcomes.PurposeThe aim of this study was to investigate whether there is an association between industry support for RCTs in implant dentistry and a greater chance of the reporting of positive outcomes, and whether there are other funding tendencies.Materials and MethodsRandomized clinical trials from five implant dentistry journals were reviewed. Data were extracted, and descriptive and inferential statistical analyses (α = 0.05), including bivariate and multivariable logistic regression, and Spearman's correlation were performed.ResultsTwo hundred eleven RCTs were included. Industry‐funded and ‐unfunded studies presented similar outcomes, in terms of positive and negative results (p ≥ 0.05). North American and European countries received more industry funding, as did high‐income countries, which showed well‐established collaboration with each other. Clinical Oral Implants Research and Clinical Implant Dentistry and Related Research published 83.6% of industry‐funded articles. Industry‐funded studies from middle‐income countries established more international collaborations with high‐income countries than did unfunded studies. Citation numbers were similar for funded and unfunded studies. The chance of RCTs being industry‐funded was higher for high‐income (odds ratio [OR] = 3.00; 95% confidence interval [CI], 0.99–9.32; p = 0.05) and North American articles (OR = 3.40; 95% CI, 1.37–8.42; p = 0.008) than in lower‐middle‐income and other continents, respectively. Higher industry funding was associated with specific topics such as “surgical procedures,” “prosthodontics topics,” and “implant macrodesign” (OR = 4.7; 95% CI, 1.45–15.20; p = 0.010) and with the increase in numbers of institutions (OR = 1.52; 95% CI, 1.16–2.0; p = 0.002).ConclusionThe available evidence suggests no association between industry funding and greater chances of the reporting of positive outcomes in implant dentistry RCTs. A strong association was identified in industry trends concerning geographic origins, higher numbers of institutions, and specific research topics.
Effect of pneumoperitoneum and Trendelenburg position on internal carotid artery blood flow measured by ultrasound during robotic prostatectomy
Authors: Yu Jihion , Park Jun‐Young , Hong Jun Hyuk , Hwang Jai‐Hyun , Kim Young‐Kug 
Published: January 2022

AbstractIntroductionRobotic prostatectomy requires pneumoperitoneum and a steep Trendelenburg position; however, this condition may compromise cerebral blood flow. Here, we evaluated the effect of pneumoperitoneum and the steep Trendelenburg position on internal carotid artery (ICA) blood flow measured by Doppler ultrasound during robotic prostatectomy.MethodsPatients who underwent robotic prostatectomy were prospectively recruited. The ICA blood flow was measured at the following five time‐points: with the patient awake and in the supine position (Ta), 10 min after anaesthetic induction in the supine position (T1), 10 (T2) and 30 (T3) min after pneumoperitoneum in the steep Trendelenburg position, and at the end of surgery in the supine position after desufflation of the pneumoperitoneum (T4). Hemodynamic and cerebrovascular variables were measured at each time‐point.ResultsA total of 28 patients were evaluated. The ICA blood flows were significantly lower at T2 and T3 than at T1 (162.3 ± 44.7 [T2] vs. 188.0 ± 49.6 ml/min [T1]; p = .002, 163.1 ± 39.9 [T3] vs. 188.0 ± 49.6 ml/min [T1]; p = .009). The ICA blood flow also differed significantly between Ta and T1 (236.8 ± 58.3 vs. 188.0 ± 49.6 ml/min; p < .001). Heart rates, cardiac indexes, peak systolic velocity, and end‐diastolic velocity were significantly lower at T2 and T3 than at T1. However, ICA diameter, mean blood pressure, and end‐tidal carbon dioxide partial pressure did not differ significantly at all time‐points.ConclusionPneumoperitoneum and the steep Trendelenburg position caused decreased ICA blood flow, suggesting that they should be carefully performed during robotic prostatectomy, especially in patients at risk of postoperative cerebrovascular accident.
Alkbh1‐mediated DNA N6‐methyladenine modification regulates bone marrow mesenchymal stem cell fate during skeletal aging
Authors: Cai Guang‐Ping , Liu Ya‐Lin , Luo Li‐Ping , Xiao Ye , Jiang Tie‐Jian , Yuan Jian , Wang Min 
Published: January 2022

AbstractObjectivesDNA N6‐methyladenine (N6‐mA) demethylase Alkbh1 participates in regulating osteogenic differentiation of mesenchymal stem cell (MSCs) and vascular calcification. However, the role of Alkbh1 in bone metabolism remains unclear.Materials and MethodsBone marrow mesenchymal stem cells (BMSCs)‐specific Alkbh1 knockout mice were used to investigate the role of Alkbh1 in bone metabolism. Western blot, qRT‐PCR, and immunofluorescent staining were used to evaluate the expression of Alkbh1 or optineurin (optn). Micro‐CT, histomorphometric analysis, and calcein double‐labeling assay were used to evaluate bone phenotypes. Cell staining and qRT‐PCR were used to evaluate the osteogenic or adipogenic differentiation of BMSCs. Dot blotting was used to detect the level of N6‐mA in genomic DNA. Chromatin immunoprecipitation (Chip) assays were used to identify critical targets of Alkbh1. Alkbh1 adeno‐associated virus was used to overexpress Alkbh1 in aged mice.ResultsAlkbh1 expression in BMSCs declined during aging. Knockout of Alkbh1 promoted adipogenic differentiation of BMSCs while inhibited osteogenic differentiation. BMSC‐specific Alkbh1 knockout mice exhibited reduced bone mass and increased marrow adiposity. Mechanistically, we identified optn as the downstream target through which Alkbh1‐mediated DNA m6A modification regulated BMSCs fate. Overexpression of Alkbh1 attenuated bone loss and marrow fat accumulation in aged mice.ConclusionsOur findings demonstrated that Alkbh1 regulated BMSCs fate and bone‐fat balance during skeletal aging and provided a potential target for the treatment of osteoporosis.
Resonant selves in ethical and theological perspective: On personhood and identity formation
Authors: Gregersen Niels Henrik 
Published: January 2022

AbstractAbsorbing insights from secular discourses on personhood, theology can provide added perspectives on human identity. (1) An attributive view of personal dignity based on divine and social recognition encompasses both capacity‐oriented and relation‐centred views of personhood. (2) Gregory of Nyssa shows Patristic resources for multifaceted ecological self in some contrast to the inner‐Trinitarian idea of ecclesial persons in John D. Zizioulas. (3) An economic Trinitarian model of personhood is proposed, in which the indwelling of Christ is balanced by a pneumatological anthropology. (4) Entering contemporary discussions, the paper proposes a “sonar” or “re‐sonant” understanding of the human per‐sona, hereby accommodating and responding to particularistic challenges to the idea of a shared human personhood.
MAPT Q336H mutation: Intrafamilial phenotypic heterogeneity in a new Italian family
Authors: Villa Cristina , Rossi Giacomina , Bizzozero Ilaria , Prioni Sara , Boiocchi Chiara , Agosta Federica , Canu Elisa , Filippi Massimo , Giaccone Giorgio , Caroppo Paola 
Published: January 2022

AbstractBackground and purposeQ336H is a rare MAPT mutation, previously found in a single patient with behavioral variant frontotemporal dementia and tau pathology (Pick bodies). Here, we describe the clinical characteristics of two members of a new family carrying the Q336H MAPT mutation.MethodsClinical, genetic, and neuroradiological assessment and follow‐up of the proband were made.ResultsAt age 37 years, the proband developed naming and object recognition impairment, due to a lack of knowledge. After 3 years, he developed behavioral disorders. Magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography showed the involvement of the left temporal pole. A diagnosis of semantic variant primary progressive aphasia (svPPA) was made. At follow‐up after 6 and 12 months, a rapid worsening of cognitive deficits occurred. His parent presented, at age 65 years, slowly progressive memory deficits without behavioral impairment, and, on MRI, evidence of mesial temporal atrophy, consistent with a clinical diagnosis of Alzheimer disease (AD).ConclusionsThis is the second family carrying the MAPT Q336H mutation reported so far. We showed that svPPA and AD‐like phenotype can be associated with this mutation. A wide clinical variability exists at the intrafamilial level for Q336H MAPT mutation, pointing to genetic and/or environmental influencing factors on disease expression. We also confirmed that svPPA can be associated with MAPT mutations, suggesting that this gene should be analyzed also in patients with svPPA, especially with early onset. In addition, an AD‐like phenotype may be associated with this mutation, suggesting its different effects on protein misfolding and aggregation.
Effect of niche components on masseter satellite cell differentiation on fibrin coatings
Authors: Lijten Olivier Willem , Rosero Salazar Doris Haydee , van Erp Merijn , Bronkhorst Ewald , Von den Hoff Johannes W. 
Published: January 2022

AbstractIn skeletal muscles, niche factors stimulate satellite cells to activate and induce muscle regeneration after injury. In vitro, matrigel is widely used for myoblast differentiation, however, is unsuitable for clinical applications. Therefore, this study aimed to analyze attachment and differentiation of satellite cells into myotubes on fibrin coatings with selected niche components. The attachment of satellite cells to fibrin alone and fibrin with niche components (laminin, collagen‐IV, laminin‐entactin complex [LEC]) were compared to matrigel. Only on matrigel and fibrin with LEC, Pax7‐positive cells attached well. Then, LEC was selected to analyze proliferation, differentiation, and fusion indices. The proliferation index at day 1 on fibrin‐LEC (22.5%, SD 9.1%) was similar to that on matrigel (30.8% [SD 11.1%]). The differentiation index on fibrin‐LEC (28.7% [SD 6.1%] at day 5 and 32.8% [SD 6.7%] at day 7) was similar to that on matrigel (40.1% [5.1%] at day 5 and 27.1% [SD 4.3%] at day 7). On fibrin‐LEC, the fusion index at day 9 (26.9% [SD 11.5%]) was similar to that on matrigel (25.5% [SD 4.7%]). Our results showed that the addition of LEC enhances the formation of myotubes on fibrin. Fibrin with LEC might be suitable to enhance muscle regeneration after surgery such as cleft palate repair and other muscle defects.
A new bioenergy model that simulates the impacts of plant‐microbial interactions, soil carbon protection, and mechanistic tillage on soil carbon cycling
Authors: Juice Stephanie M. , Walter Christopher A. , Allen Kara E. , Berardi Danielle M. , Hudiburg Tara W. , Sulman Benjamin N. , Brzostek Edward R. 
Published: January 2022

AbstractAdvancing our predictive understanding of bioenergy systems is critical to design decision tools that can inform which feedstock to plant, where to plant it, and how to manage its production to provide both energy and ecosystem carbon (C) benefits. Here, we lay the foundation for that advancement by integrating recent developments in the science of belowground processes in shaping the C cycle into a new bioenergy model, FUN‐BioCROP (Fixation and Uptake of Nitrogen‐Bioenergy Carbon, Rhizosphere, Organisms, and Protection). We show that FUN‐BioCROP can approximate the historical trajectory of soil C dynamics as natural ecosystems were successively converted into intensive agriculture and bioenergy systems. This ability relies in part on a novel tillage representation that mechanistically models tillage as a process that increases microbial access to C. Importantly, the impacts of tillage and feedstock choice also influence FUN‐BioCROP simulations of warming responses with no‐till perennial feedstocks, miscanthus, and switchgrass, having more C that is unprotected and susceptible to warming than tilled annual feedstocks like corn–corn–soybean. However, this susceptibility to warming is balanced by a greater potential for increases in belowground C allocation to enhance soil C stocks in perennial systems. Collectively, our model results highlight the importance of belowground processes in evaluating the ecosystem C benefits of bioenergy production.
The structured interview's resistance to gender discrimination under cognitive load
Authors: Kith Sulan , Cassidy Scott A. , Powell Deborah M. 
Published: January 2022

AbstractJob interviews are cognitively demanding tasks for interviewers. However, it is unclear whether the high cognitive load (CL) that interviewers face will ultimately compromise the resistance to discrimination that otherwise distinguishes structured interviews from other selection methods. Using a two‐study experimental design, we explored the effect of cognitive load on gender discrimination in structured job interviews. In Study 1, participants completed an online interview simulation in which they assessed both a male and a female candidate applying for either a male‐ or female‐dominated job, while under either a high or low degree of cognitive load. Participants provided ratings of each candidate's suitability for the job as well as a final, ipsative hiring decision. Study 2 served as a larger replication of Study 1. Overall, CL was not found to affect candidate ratings. These results support the structured interview's general resistance to discrimination.
Solving the multi‐objective bike routing problem by meta‐heuristic algorithms
Authors: Nunes Pedro , Moura Ana , Santos José 
Published: January 2022

AbstractThe Multi‐Objective Bike Routing Problem (MOBRP) addressed in this paper consists in finding a set of good solutions that represents the trade‐off between cyclist preferences when choosing a route. We propose a new genetic approach to solve the MOBRP (NGA‐MOBRP) with a new mutation operator. To test the approach, we consider four conflicting criteria: safety, travel distance, travel time, and comfort. The well‐known Nondominated Sorting Genetic Algorithm II (NSGA‐II) is also implemented in the MOBRP context, and its weaknesses are identified and mitigated in the proposed NGA‐MOBRP. The developed approach is compared with other published works in this field, namely another genetic algorithm and a Multi‐Objective Simulated Annealing (MOSA) approach. The computational results show that the approach developed in this work obtains better results than the previously mentioned published approaches.
Peculiar electric properties of polarized layer in alkaline silicate glasses
Authors: Koroleva Ekaterina , Reshetov Ilya , Babich Ekaterina , Vakhrushev Sergey , Tagantsev Dmitry , Lipovskii Andrey 
Published: January 2022

AbstractBroadband dielectric spectroscopy (BDS) was applied to study polarization phenomena in alkaline silicate glasses, in particular, properties and structure of subsurface (anodic) polarized layers forming in poling with deposited film electrodes of different structures. A model of poled glasses which does not contradict experimental data is proposed. In accordance with the model, a poled glass is presented as two resistor‐capacitor circuits in a series connection, one of which is the polarized layer and another is the rest of the sample. It is found that the electric properties of the layers essentially depend on the structure of the anodic electrode used in glass poling. It is also shown that the dielectric response of poled glass samples is mainly determined by the electric properties of the submicron polarized layers and this gives an opportunity to reveal specific properties of the layers rather than ones of the glass sample bulk. Revealed temperature dependence of DC conductivity of the polarized layers obeys Arrhenius's law, and determining activation energy does not depend on the electrode. Finally, it is noted that today above‐mentioned information about polarized layers can be obtained only by BDS.
Temporal trends and in‐hospital complications of catheter ablation for atrial fibrillation among patients with moderate and advanced chronic kidney diseases: 2005−2018
Authors: Prasitlumkum Narut , Chokesuwattanaskul Ronpichai , Kaewput Wisit , Thongprayoon Charat , Tokavanich Nithi , Bathini Tarun , Boonpheng Boonphiphop , Vallabhajosyula Saraschandra , Cheungpasitporn Wisit , Jongnarangsin Krit 
Published: January 2022

AbstractIntroductionReal‐world data on atrial fibrillation (AF) ablation among moderate and advanced chronic kidney disease (CKD) patients have so far remained scarce, especially in‐hospital AF ablation outcomes.MethodsWe drew data from the US National Inpatient Sample to identify hospitalized patients who underwent AF ablation between 2005 and 2018, and further stratified by CKD classification. We assessed the trend of AF ablation, as well as its complications.ResultsA total of 152 630 patients who were primarily hospitalized for AF and underwent ablation were estimated. Among these, CKD patients were found in a total of 1509 participants, with 978, 206, and 325 under CKD3, CKD4, and CKD5/ESKD, respectively. There was a significant increment in admission rates for AF ablation in the CKD population across all CKD classifications (p < .001). All CKD patients were statistically older, with higher coexisting comorbidities, while hypertension was found substantially lower than non‐CKD patients (p ≤ .001). Importantly, CKD, especially CKD3 and CKD5/ESKD, was significantly associated with an increased risk of total complications, and total bleeding, Neurological complications were found statistically lower in CKD patients (p = .029), and no mortality rates were significantly different (p = .287).ConclusionOur study observed an increase in admission trends for AF ablation among moderate and advanced CKD patients from 2005 to 2018. CKD was strongly associated with higher procedure‐related complications and bleeding, but neurological safety profiles and mortalities rates were nonsignificantly different.
Catheter contact angle influences local impedance drop during radiofrequency catheter ablation: Insight from a porcine experimental study with 2 different LI‐sensing catheters
Authors: Matsuura Gen , Fukaya Hidehira , Ogawa Emiyu , Kawakami Sota , Mori Hitoshi , Saito Daiki , Sato Tetsuro , Nakamura Hironori , Ishizue Naruya , Oikawa Jun , Kishihara Jun , Niwano Shinichi , Ako Junya 
Published: January 2022

AbstractBackgroundLocal impedance (LI) can indirectly measure catheter contact and tissue temperature during radiofrequency catheter ablation (RFCA). However, data on the effects of catheter contact angle on LI parameters are scarce. This study aimed to evaluate the influence of catheter contact angle on LI changes and lesion size with two different LI‐sensing catheters in a porcine experimental study.MethodsLesions were created by the INTELLANAV MiFi™ OI (MiFi) and the INTELLANAV STABLEPOINT™ (STABLEPOINT). RFCA was performed with 30 W and a duration of 30 s. The contact force (CF) (0, 5, 10, 20, and 30 g) and catheter contact angle (30°, 45°, and 90°) were changed in each set (n = 8 each). The LI rise, LI drop, and lesion size were evaluated.ResultsThe LI rise increased as CF increased. There was no angular dependence with the LI rise under all CFs in the MiFi. On the other hand, the LI rise at 90° was lower than at 30° under 5 and 10 g of CF in STABLEPOINT. The LI drop increased as CF increased. Regarding the difference in catheter contact angles, the LI drop at 90° was lower than that at 30° for both catheters. The maximum lesion widths and surface widths were smaller at 90° than at 30°, whereas there were no differences in lesion depths.ConclusionThe LI drop and lesion widths at 90° were significantly smaller than those at 30°, although the lesion depths were not different among the 3 angles for the MiFi and STABLEPOINT.
Outcomes in congenital and childhood complete atrioventricular block: A meta‐analysis
Authors: Deshpande Saurabh , Shenthar Jayaprakash , Khanra Dibbendhu , Isath Ameesh , Banavalikar Bharatraj , Reddy Satish , Krishnappa Darshan , Khan Hassan , Kella Danesh , Padmanabhan Deepak 
Published: January 2022

AbstractBackgroundThe long‐term outcomes of patients with congenital and childhood complete atrioventricular block (CCAVB/CAVB) after pacemaker implantation are unclear.MethodsWe performed a meta‐analysis of all the studies of CCAVB. A systematic search of PubMed and CENTRAL databases from January 1, 1967 to January 31, 2020 was performed. The quality of studies included was critically appraised using the Newcastle–Ottawa scale, and outcome data were analyzed using the restricted maximum likelihood function.ResultsTwenty‐nine studies were eligible for analysis, with a total of 1553 patients. The all‐cause‐mortality was 5.7% (95% confidence interval [CI]: 2.5%–9.9%), while pacing‐induced cardiomyopathy (PICM) was seen in 3.8% (95% CI: 1.2–7.2). Diagnosis at birth (effect size [ES] [95%CI]: −2.23 [−0.36 to −0.10]; p < .001), presence of congenital heart disease (ES [95%CI]: −0.67 [0.41–0.93]; p < .001), younger age at pacemaker implantation (ES [95%CI]: −0.01 [−0.02 to −0.001]; p = .02), and duration of pacing (ES [95%CI]: −0.03 [−0.05 to −0.003]; p = .03), were associated with an higher mortality on binominal logistic regression. None of the parameters were significant on multivariate analysis.ConclusionPooled proportional mortality in patients with CCAVB and CAVB is 5.7% with an infrequent incidence of PICM (3.8%) in the paced patients with AVB suggesting that pacing in these patients is an effective management strategy with a low incidence of long‐term side effects. Registry and randomized data can throw additional light regarding the natural history and appropriate management strategy in these patients.