bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes
Authors: Augustine Tracy , Kumar Manoj , Al Khodor Souhaila , van Panhuys Nicholas 
Published: June 2022

AbstractThe hygiene hypothesis has been popularized as an explanation for the rapid increase in allergic disease observed over the past 50 years. Subsequent epidemiological studies have described the protective effects that in utero and early life exposures to an environment high in microbial diversity have in conferring protective benefits against the development of allergic diseases. The rapid advancement in next generation sequencing technology has allowed for analysis of the diverse nature of microbial communities present in the barrier organs and a determination of their role in the induction of allergic disease. Here, we discuss the recent literature describing how colonization of barrier organs during early life by the microbiota influences the development of the adaptive immune system. In parallel, mechanistic studies have delivered insight into the pathogenesis of disease, by demonstrating the comparative effects of protective T regulatory (Treg) cells, with inflammatory T helper 2 (Th2) cells in the development of immune tolerance or induction of an allergic response. More recently, a significant advancement in our understanding into how interactions between the adaptive immune system and microbially derived factors play a central role in the development of allergic disease has emerged. Providing a deeper understanding of the symbiotic relationship between our microbiome and immune system, which explains key observations made by the hygiene hypothesis. By studying how perturbations that drive dysbiosis of the microbiome can cause allergic disease, we stand to benefit by delineating the protective versus pathogenic aspects of human interactions with our microbial companions, allowing us to better harness the use of microbial agents in the design of novel prophylactic and therapeutic strategies.
Renal Disease and Systemic Sclerosis: an Update on Scleroderma Renal Crisis
Authors: Cole Alice , Ong Voon H. , Denton Christopher P. 
Published: June 2022

AbstractScleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc) with a mortality of 20% at 6 months. Once the leading cause of mortality in scleroderma (SSc), it remains a serious complication, often necessitating level three care for patients affected. Whilst renal outcomes have significantly improved following the advent of angiotensin-converting enzyme inhibitor (ACEi) therapy, SRC remains a precarious challenge for clinicians, due to lack of preventative measures and the fact that patients can rapidly decline despite best medical management. Large cohort studies spanning decades have allowed clear identification of phenotypes particularly at risk of developing SRC thus allowing enhanced monitoring and early identification in those individuals. Novel urinary biomarkers for renal disease in SSc may offer a new window for early identification of SRC patients and response to treatment. Multiple studies have demonstrated increased activity of complement pathways in SRC with some anecdotal cases exhibiting serological response to treatment with eculizumab where ACEi and therapeutic plasma exchange (TPE) were not successful. Endothelin-1 blockade, a therapeutic strategy in other SSc vasculopathies, has shown potential as a target but clinical trials are yet to show a clear treatment benefit. Clear guidelines for the management of SRC are in place to standardise care and facilitate early collaboration between rheumatology and renal physicians. Outcomes following renal transplant have improved but the mortality of SRC remains high, indicating the need for continued exploration of the mechanisms precipitating and exacerbating SRC in order to develop novel therapies.
Social Insurance for Long-term Care
Authors: Karagiannidou Maria , Wittenberg Raphael 
Published: June 2022

AbstractThe issue of how best to finance long-term care (LTC) is the subject of recent reforms, forthcoming reforms or continuing debate in various countries and remains as relevant and challenging as ever. LTC services are crucial to the wellbeing of large numbers of older adults who need help with everyday tasks.Demand for LTC for older adults is projected to rise across developed and developing countries as the number of older adults rises. Supply of care services is likely to remain constrained due to shortages of long-term care workforce and financial constraints in many countries, and the financial risks associated with LTC remain.Financing of LTC is a complicated issue which raises considerations of economic efficiency and incentives, equity including intergenerational equity, the balance of risk between public and private funding, and sustainability of public expenditures.The aim of this paper is to discuss analytically the case for social insurance as an equitable and efficient way to finance LTC. The paper considers social insurance systems, especially in Germany and Japan, in comparison with safety net tax funded systems such as in England and the USA and more generous tax funded systems such as in Sweden and Denmark. Social insurance has advantages and disadvantages compared with these other systems. It tends to be associated with greater clarity and acceptability since it involves collection of revenues ear marked for LTC and, at least in principle, a link between contributions and benefits on the basis of clear eligibility criteria.
Industry 4.0-driven operations and supply chains for the circular economy: a bibliometric analysis
Authors: Hettiarachchi Biman Darshana , Seuring Stefan , Brandenburg Marcus 
Published: June 2022

AbstractThe Industry 4.0 (I4.0) concept paves the way for the circular economy (CE) as advanced digital technologies enable sustainability initiatives. Hence, I4.0-driven CE-oriented supply chains (SCs) have improved sustainable performance, flexibility and interoperability. In order to smoothly embrace circular practices in digitally enabled SCs, quantitative techniques have been identified as crucial. Therefore, the intersection of I4.0, CE, supply chain management (SCM) and quantitative techniques is an emerging research arena worthy of investigation. This article presents a bibliometric analysis to identify the established and evolving research clusters in the topological analysis by identifying collaboration patterns, interrelations and the studies that significantly dominate the intersection of the analysed fields. Further, this study investigates the current research trends and presents potential directions for future research. The bibliometric analysis highlights that additive manufacturing (AM), big data analytics (BDA) and the Internet of Things (IoT) are the most researched technologies within the intersection of CE and sustainable SCM. Evaluation of intellectual, conceptual and social structures revealed that I4.0-driven sustainable operations and manufacturing are emerging research fields. This study provides research directions to guide scholars in the further investigation of these four identified fields while exploring the potential quantitative methods and techniques that can be applied in I4.0-enabled SCs in the CE context.
ANO10 Function in Health and Disease
Authors: Chrysanthou Androniki , Ververis Antonis , Christodoulou Kyproula 
Published: June 2022

Abstract
Anoctamin 10 (ANO10), also known as TMEM16K, is a transmembrane protein and member of the anoctamin family characterized by functional duality. Anoctamins manifest ion channel and phospholipid scrambling activities and are involved in many physiological processes such as cell division, migration, apoptosis, cell signalling, and developmental processes. Several diseases, including neurological, muscle, blood disorders, and cancer, have been associated with the anoctamin family proteins. ANO10, which is the main focus of the present review, exhibits both scrambling and chloride channel activity; calcium availability is necessary for protein activation in either case. Additional processes implicating ANO10 include endosomal sorting, spindle assembly, and calcium signalling. Dysregulation of calcium signalling in Purkinje cells due to ANO10 defects is proposed as the main mechanism leading to spinocerebellar ataxia autosomal recessive type 10 (SCAR10), a rare, slowly progressive spinocerebellar ataxia. Regulation of the endolysosomal pathway is an additional ANO10 function linked to SCAR10 aetiology. Further functional investigation is essential to unravel the ANO10 mechanism of action and involvement in disease development.
Intra-pericardial thrombin injection as bailout strategy in iatrogenic pericardial tamponade
Authors: Rottländer D. , Saal M. , Degen H. , Haude M. 
Published: June 2022

Abstract
Background
Cardiac tamponade is a rare but life-threatening complication of cardiac interventions. Despite prompt pericardiocentesis, clinical management can be challenging and sometimes haemodynamic stabilisation is difficult to achieve. Intra-pericardial thrombin injection after pericardiocentesis promotes haemostasis and acts as a sealing agent, as previously described for left ventricular free-wall rupture. We aimed to evaluate intra-pericardial thrombin injection as a bailout strategy for pericardial tamponade following percutaneous cardiac interventions.

Methods
In a 5-year single-centre retrospective analysis we identified 31 patients with cardiac tamponade due to percutaneous intracardiac procedures. Intra-pericardial thrombin injection as a bailout strategy was administered in 5 of 31 patients (16.1%).

Results
Patients receiving intra-pericardial thrombin were in a more critical state when thrombin was applied, as demonstrated by a higher rate of resuscitation (40% versus 26.9%) and a trend toward a prolonged stay in the intensive care unit (177.6 ± 84.0 vs 98.0 ± 31.4 h). None of the patients with pericardial tamponades treated with intra-pericardial thrombin needed cardiothoracic surgery. Mortality after 30 days was lower with intra-pericardial thrombin injection than with standard treatment (0% vs 15.4%). We observed no complications using intra-pericardial thrombin.

Conclusion
Intra-pericardial thrombin injection could be considered as a bailout strategy for patients with iatrogenic pericardial tamponade due to percutaneous procedures. We recommend further evaluation of this technique in the clinical management of refractory pericardial tamponade.
Covalent Immobilization of Aldehyde and Alcohol Dehydrogenases on Ordered Mesoporous Silicas
Authors: Pietricola Giuseppe , Dosa Melodj , Ottone Carminna , Fino Debora , Piumetti Marco , Tommasi Tonia 
Published: June 2022

Abstract
Purpose
This work studies the immobilization of two enzymes, the alcohol dehydrogenase (ADH) and the aldehyde dehydrogenase (AldDH) both from Saccharomyces cerevisiae, which could be used to produce high value-added molecules from carboxylic acids embedded in anaerobic digestate.

Methods
In particular, three mesoporous siliceous materials, with different specific surface areas and pore sizes, (MSU-H, MSU-F and MCF0.75) were used as supports for covalent immobilization. The support materials were characterized by complementary techniques. Then, after a functionalization, creating a covalent bond between the enzyme and the support was performed. The specific activity and immobilization yield of the biocatalysts were then evaluated.

Results
The best results were obtained with MSU-H and MSU-F, resulting in an immobilization yield greater than 50% in all cases, a specific activity of 0.13 IU/gsupp with the AldDH/MSU-H, 0.10 IU/gsupp with AldDH/MSU-F, 48.6 IU/gsupp with ADH/MSU-H and 12.6 IU/gsupp with ADH/MSU-H. These biocatalysts were then characterized by optimal pH and temperature and the stability factor was evaluated. With ADH/MSU-F no decrease in activity was observed after 120 h incubated at 50 °C. Finally, the biocatalysts AldDH/MSU-H and ADH/MSU-H were used to perform the reduction reaction and it was seen that after five reaction cycles the residual activity was greater than 20% in both cases.

Conclusion
The ADH and AldDH enzymes have been successfully immobilized on mesoporous siliceous supports, considerably increasing their thermal stability and being able to reuse them for several reaction cycles. The use of this immobilization and these supports is adaptable to a wide variety of enzymes.

Graphical Abstract
Adaptive Selbstregulation von Sportstudierenden: Unterscheiden sich angehende Sportlehrkräfte von Sportstudierenden mit einem anderen Berufsziel?
Authors: Fischer Britta , Poweleit André , Konowalczyk Svenja 
Published: June 2022

ZusammenfassungEine adaptive Selbstregulation gilt in der Professionsforschung zum Lehrer*innenberuf als wichtige individuelle Ressource von Lehrkräften für die Bewältigung von beruflichen Belastungen. Dies legt eine Auseinandersetzung mit der Frage nahe, über welche Regulationsprofile angehende Sportlehrkräfte hinsichtlich der Bewältigung von Anforderungen verfügen und welche Implikationen sich hiermit für die universitäre Lehrer*innenbildung ergeben. Von Interesse ist dabei nicht nur, ob Sport-Lehramtsstudierende über eher günstige oder eher ungünstige Verhaltensstile verfügen, sondern auch, ob sie Spezifika gegenüber anderen Sportstudierenden aufweisen. Die Ergebnisse einer Befragung von 851 Sportstudierenden sprechen dafür, dass sich diese zu vier verschiedenen Profilen der Selbstregulation zuordnen lassen. Signifikante Unterschiede existieren hinsichtlich der Verteilung auf diese Muster zwischen Studierenden des Lehramts und anderer sportwissenschaftlicher Studiengänge. So weisen Lehramtsstudierende mit einer höheren Wahrscheinlichkeit häufiger ein Schonungsmuster und seltener einen risikobehafteten Regulationsstil auf. Innerhalb der Subgruppe der Lehramtsstudierenden lassen sich marginale Unterschiede in der Musterverteilung in Abhängigkeit vom Geschlecht und keine Unterschiede für das Zweitfach nachweisen.
Non-epistemic values and scientific assessment: an adequacy-for-purpose view
Authors: Lusk Greg , Elliott Kevin C. 
Published: June 2022

AbstractThe literature on values in science struggles with questions about how to describe and manage the role of values in scientific research. We argue that progress can be made by shifting this literature’s current emphasis. Rather than arguing about how non-epistemic values can or should figure into scientific assessment, we suggest analyzing how scientific assessment can accommodate non-epistemic values. For scientific assessment to do so, it arguably needs to incorporate goals that have been traditionally characterized as non-epistemic. Building on this insight, we show how the adequacy-for-purpose framework recently developed for assessing scientific models can provide a general framework for describing scientific assessment so that it goes beyond purely epistemic considerations. Adopting this framework has significant advantages and opens the possibility of effecting a partial rapprochement between critics and proponents of the value-free ideal.
On Pharmacology and Multistability: a Commentary on Marco Pavanini
Authors: Lemmens Pieter 
Published: June 2022

Abstract This is a commentary piece on Marco Pavanini's article ' ‘Multistability and Derrida’s Différance: Investigating the Relations Between Postphenomenology and Stiegler’s General Organology' in which I critically extend upon his comparative analysis of postphenomenology''s notion of multistability and Stiegler's conception of organology, focusing in particular on the pharmacological nature of Stiegler's organology and the latter's most recent re-interpretation of it in terms of entropy and negentropy. Among other things I show, and both are more intended as additions than criticisms with respect to Pavanini’s very helpful comparison, (1) that the most important concern for Stiegler in theorizing technology is the fact that the transductive relations between the three organ systems distinguished in his pharmaco-organology of technology open up affective or libidinal circuits between these systems, i.e., circuits either of desire or drive depending on the way the pharmakon is adopted or not, and that these circuits are fundamentally noetic circuits vulnerable to denoetization; and (2) that these libidinal-noetic circuits as conditioned by technology should be interpreted in terms of entropy and negentropy. Both insights are lacking in postphenomenology, which generally fails to consider the irreducibly destitutive character of all technology, rightfully emphasized by Pavanini, since it lacks a genuine pharmacological awareness.
Preparation of a ε-caprolactonic diterpenoid derivate by unexpected oxidative cleavage/lactonization of 2-oxoaustroeupatol
Authors: Chacón-Morales Pablo A. , Amaro-Luis Juan M. , Rojas Fermín Luis Beltrán , Jacquet Rémi , Deffieux Denis , Pouységu Laurent , Quideau Stéphane 
Published: June 2022

AbstractFrom aerial parts of Austroeupatorium inulifolium was isolated the ent-nor-furano triol labdane austroeupatol 1. The compound 1 was treated with IBX showing an unexpected selectivity at the potentially oxidizable sites of the substrate yielding the 2-oxoaustroeupatol (2) and 2,19-dioxoaustroeupatol (3). The treatment of 2 with sodium periodate yields a heterocyclic derivative (ε-caprolactone derivate 4) formed by oxidative cleavage and unexpected intramolecular attack of the hydroxymethylene (C-19) oxygen to the ketonic carbon (C-2). A plausible mechanistic pathway for the obtention of compound 4 is proposed.
Graphical Abstract
Lost in translation? The European Convention on Human Rights at the Court of Arbitration for Sport
Authors: Duval Antoine 
Published: June 2022

AbstractThe Court of Arbitration for Sport (CAS) is not known as a human rights court. Instead, its primary focus is on applying and interpreting the regulations of international (and sometimes national) sport governing bodies (SGBs). It is only recently that the intersection between the CAS jurisprudence and human rights has become of interest in the academic literature and public debates. In particular, the Mutu and Pechstein decision of the European Court of Human Rights (ECtHR) in October 2018 made clear that the CAS does not escape the indirect scrutiny of the Strasbourg court. Nevertheless, until today, very few publications have been dedicated to the interplay between the European Convention on Human Rights (ECHR) and the CAS. This paper aims to contribute to remedying this want by charting the CAS awards in which a reference to the ECHR or a decision of the ECtHR was made and tracing the impact and function of such references in the CAS jurisprudence. The findings highlight the various functions of the references to the ECHR in CAS awards, the discrepancies between some of the interpretations of the ECHR advanced by the CAS and the ECtHR’s own understanding of the Convention, and the limited success of appellants to challenge SGBs’ decisions on the basis of the ECHR. The paper concludes by arguing that the CAS would need to be institutionally reformed in order for human rights to act as an effective check on the transnational power of SGBs in CAS proceedings.
Informationsüberflutung am Arbeitsplatz
Authors: Kersten Norbert , Junghanns Gisa 
Published: June 2022

Zusammenfassung
Hintergrund
Der psychischen Belastung kommt in unserer Arbeitswelt eine hohe Bedeutung zu, da sie Auswirkungen auf die Beanspruchung und damit auch auf das gesundheitliche Geschehen haben kann. Deshalb wird sie in der sogenannten Gefährdungsbeurteilung berücksichtigt. Voraussetzung für die Ermittlung von Gefährdungen und der Entwicklung von wirksamen Maßnahmen ist, dass die konkreten psychischen Belastungsfaktoren der Arbeit bekannt sind bzw. deren gesundheitliche Bedeutung ermittelt wurde. Eine gezielte Änderung von Arbeitsbedingungen, die sich als gesundheitlich bedeutsam erwiesen haben und somit eine Gefährdung darstellen, sollte gesundheitliche Zielgrößen wie gesundheitliche Beschwerden positiv beeinflussen.

Material und Methoden
Die vorliegende Studie prüft auf der Basis der Daten der BAuA-Arbeitszeitbefragungen 2015 und 2019 im Längsschnitt den Zusammenhang von gesundheitlichen Beschwerden und dem Erleben von Informationsüberflutung. Die Analysen wurden in Form binomialer logistischer Regressionsmodelle adjustiert nach Alter und beruflicher Stellung ausgeführt.

Ergebnisse
Bei den meisten in dieser Studie geprüften Beschwerdearten zeigte sich mit zunehmender Häufigkeit des Erlebens von Informationsüberflutung über die Zeit ein Ansteigen der Beschwerdeprävalenz bzw. eine Abnahme der Beschwerdeprävalenz bei sinkender Häufigkeit der Informationsüberflutung.

Diskussion
Bei allen berücksichtigten Beschwerdearten hat das Erleben von Informationsüberflutung Konsequenzen für die Gesundheit und erweist sich somit als ein ernst zu nehmender Gefährdungsfaktor im Arbeitsleben, der bei der Ermittlung von Gefährdungen im Rahmen des Arbeitsschutzes berücksichtigt werden sollte. Um das Niveau der Belastung durch hohe Informationsmengen zu verringern bzw. um Arbeit gesundheitsgerecht zu gestalten, sind Maßnahmen erforderlich, die an den Ursachen der Informationsüberflutung und deren Bedingungen am Arbeitsplatz ansetzen.
Intelligent Operation Monitoring of an Ultra-Precision CNC Machine Tool Using Energy Data
Authors: Selvaraj Vignesh , Xu Zhicheng , Min Sangkee 
Published: June 2022

AbstractUltra-precision CNC machine tools play a significant role in the machining of precision dies and molds, optics, consumer electronics, etc., Due to the nature of ultra-precision machining, a subtle change in process condition, machine anomalies, etc. may significantly influence the machining outcome. Hence, continuous monitoring of the equipment’s operation is required to better understand the variations associated with the process and the machine. The conventional monitoring platform requires comprehensive data analysis using multiple sensors, and controller data to detect, diagnose, and prognose machine and process conditions. This increases the cost and complexity of installing a monitoring platform. The energy consumption data contains valuable information that could be potentially used to identify machine and process variations. The information can also be used to develop potential energy-saving strategies in an effort towards Green Manufacturing. This paper proposes an intelligent energy monitoring method using a 1-dimensional convolutional neural network (1D-CNN) to effortlessly and accurately obtain the working status information of the machine with minimal retrofitting. The 1D-CNN uses the energy consumption data to determine the equipment’s operation status by identifying the working components and the feed rate of the moving axis. The hyper-parameters of the developed model were optimized to improve the prediction accuracy. The paper also compares different Deep Learning and Machine Learning algorithms to gauge their effective performance in this application. Finally, the model with the highest accuracy was validated on a 5-axis ultra-precision CNC machine tool. Results show that 1D-CNN performs better than multi-layer neural networks and machine learning algorithms in processing time-series datasets. The classification accuracy of 1D-CNN on the detection of operation status and feed rate of each axis can reach 95.7 and 91.4%, respectively. Further studies are currently in progress to improve prediction accuracy of the model, and to detect subtle changes in energy consumption which would enable identification of the machine and process anomalies.