bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linear regression with partially mismatched data: local search with theoretical guarantees
Authors: Mazumder Rahul , Wang Haoyue 
Published: August 2022

AbstractLinear regression is a fundamental modeling tool in statistics and related fields.
In this paper, we study an important variant of linear regression in which the predictor-response pairs are partially mismatched. We use an optimization formulation to simultaneously learn the underlying regression coefficients and the permutation corresponding to the mismatches. The combinatorial structure of the problem leads to computational challenges. We propose and study a simple greedy local search algorithm for this optimization problem that enjoys strong theoretical guarantees and appealing computational performance. We prove that under a suitable scaling of the number of mismatched pairs compared to the number of samples and features, and certain assumptions on problem data; our local search algorithm converges to a nearly-optimal solution at a linear rate. In particular, in the noiseless case, our algorithm converges to the global optimal solution with a linear convergence rate. Based on this result, we prove an upper bound for the estimation error of the parameter. We also propose an approximate local search step that allows us to scale our approach to much larger instances. We conduct numerical experiments to gather further insights into our theoretical results, and show promising performance gains compared to existing approaches.
The fast invasion of Europe by the box tree moth: an additional example coupling multiple introduction events, bridgehead effects and admixture events
Authors: Bras Audrey , Lombaert Eric , Kenis Marc , Li Hongmei , Bernard Alexis , Rousselet Jérôme , Roques Alain , Auger-Rozenberg Marie-Anne 
Published: August 2022

AbstractIdentifying the invasion routes of non-native species is crucial to understanding invasions and customizing management strategies. The box tree moth,Cydalima perspectalis, is native to Asia and was recently accidentally introduced into Europe as a result of the ornamental plant trade. Over the last 15 years, it has spread across the continent and has reached the Caucasus and Iran. It is threateningBuxustrees in both urban areas and forests. To investigate the species’ invasion routes, native and invasive box tree moth populations were sampled, and moth’s genetic diversity and structure were compared using microsatellite markers. Our approximate Bayesian computation analyses strongly suggest that invasion pathways were complex. Primary introductions originating from eastern China probably occurred independently twice in Germany and once in the Netherlands. There were also possibly bridgehead effects, where at least three invasive populations may have served as sources for other invasive populations within Europe, with indication of admixture between the two primary invasive populations. The bridgehead populations were likely those in the countries that play a major role in the ornamental plant trade in Europe, notably Germany, the Netherlands, and Italy. All these invasion processes likely facilitated its fast expansion across Europe and illustrate the role played by the ornamental plant trade not only in the moth’s introduction from China but also in the species’ spread across Europe, leading to an invasion with a complex pattern.
‘He’s out of control, I’m out of control, it’s just – I’ve got to do something’: a narrative inquiry of child to parent violence
Authors: Toole-Anstey Chye , Townsend Michelle L , Keevers Lynne 
Published: August 2022

AbstractFamilies globally experience child to parent violence (CPV). Stories of CPV have been considered at an individual and collective level to ascertain themes in parents’ accounts to identify enabling and restraining factors for CPV. However, understanding the societal narratives, defined as discourses, which have a multi-directional and entangled relationship with individual recounts of CPV have yet to be investigated. This research utilizes Narrative Inquiry with participatory approaches to explicate the societal narratives within mothers’ recounts of CPV. This analysis, guided by the interactional and discursive view of violence, and response-based practice, identifies societal narratives which set the conditions for what is possible and impossible in relation to CPV. The analysis contributes to understanding the attitudes of minimization and concealment of violence within parents’ accounts of CPV. The mothers’ recounts were constrained and made possible by the ‘good’ mother narrative and narratives of adolescence and gender. This research examines the intra-actions mothers’ recounts have with the societal narratives, and the performance of their roles as (en)actors of the subject positions ‘mother’ and ‘child’. Implications for practice and research include: consideration to practitioner’s views of power and subject positions in a parent and child relationship when working with CPV; and practitioners to be critical of essentialism and gender in working with CPV. This study posits a practical demonstration for using the response-based practice approach in research; and a way of viewing stories which can be incorporated in working with families experiencing CPV.
Aß Pathology and Neuron–Glia Interactions: A Synaptocentric View
Authors: Huffels Christiaan F. M. , Middeldorp Jinte , Hol Elly M. 
Published: August 2022

AbstractAlzheimer’s disease (AD) causes the majority of dementia cases worldwide. Early pathological hallmarks include the accumulation of amyloid-ß (Aß) and activation of both astrocytes and microglia. Neurons form the building blocks of the central nervous system, and astrocytes and microglia provide essential input for its healthy functioning. Their function integrates at the level of the synapse, which is therefore sometimes referred to as the “quad-partite synapse”. Increasing evidence puts AD forward as a disease of the synapse, where pre- and postsynaptic processes, as well as astrocyte and microglia functioning progressively deteriorate. Here, we aim to review the current knowledge on how Aß accumulation functionally affects the individual components of the quad-partite synapse. We highlight a selection of processes that are essential to the healthy functioning of the neuronal synapse, including presynaptic neurotransmitter release and postsynaptic receptor functioning. We further discuss how Aß affects the astrocyte’s capacity to recycle neurotransmitters, release gliotransmitters, and maintain ion homeostasis. We additionally review literature on how Aß changes the immunoprotective function of microglia during AD progression and conclude by summarizing our main findings and highlighting the challenges in current studies, as well as the need for further research.
Partial Lasserre relaxation for sparse Max-Cut
Authors: Campos Juan S. , Misener Ruth , Parpas Panos 
Published: August 2022

AbstractA common approach to solve or find bounds of polynomial optimization problems like Max-Cut is to use the first level of the Lasserre hierarchy. Higher levels of the Lasserre hierarchy provide tighter bounds, but solving these relaxations is usually computationally intractable. We propose to strengthen the first level relaxation for sparse Max-Cut problems using constraints from the second order Lasserre hierarchy. We explore a variety of approaches for adding a subset of the positive semidefinite constraints of the second order sparse relaxation obtained by using the maximum cliques of the graph’s chordal extension. We apply this idea to sparse graphs of different sizes and densities, and provide evidence of its strengths and limitations when compared to the state-of-the-art Max-Cut solver BiqCrunch and the alternative sparse relaxation CS-TSSOS.
Internal constraints for phenomenal externalists: a structure matching theory
Authors: Dalbey Bryce , Saad Bradford 
Published: August 2022

AbstractWe motivate five constraints on theorizing about sensory experience. We then propose a novel form of naturalistic intentionalism that succeeds where other theories fail by satisfying all of these constraints. On the proposed theory, which we callstructure matching tracking intentionalism, brains states track determinables. Internal structural features of those states select determinates of those determinables for presentation in experience. We argue that this theory is distinctively well-positioned to both explain internal-phenomenal structural correlations and accord external features a role in fixing phenomenology. In addition, we use the theory to shed light on how one comes to experience “missing shades”.
Addition of FFRct in the diagnostic pathway of patients with stable chest pain to reduce unnecessary invasive coronary angiography (FUSION)
Authors: Sharma S. P. , Hirsch A. , Hunink M. G. M. , Cramer M. J. M. , Mohamed Hoesein F. A. A. , Geluk C. A. , Kramer G. , Gratama J. W. C. , Braam R. L. , van der Zee P. M. , Yassi W. , Wolters S. L. , Gürlek C. , Pundziute G. , Vliegenthart R. , Budde R. P. J. 
Published: August 2022

Abstract
Background
Coronary computed tomography angiography (CCTA) is widely used in the diagnostic work-up of patients with stable chest pain. CCTA has an excellent negative predictive value, but a moderate positive predictive value for detecting coronary stenosis. Computed tomography-derived fractional flow reserve (FFRct) is a non-invasive, well-validated technique that provides functional assessment of coronary stenosis, improving the positive predictive value of CCTA. However, to determine the value of FFRct in routine clinical practice, a pragmatic randomised, controlled trial (RCT) is required. We will conduct an RCT to investigate the impact of adding FFRct analysis in the diagnostic pathway of patients with a coronary stenosis on CCTA on the rate of unnecessary invasive coronary angiography, cost-effectiveness, quality of life and clinical outcome.

Methods
The FUSION trial is a prospective, multicentre RCT that will randomise 528 patients with stable chest pain and anatomical stenosis of ≥ 50% but < 90% in at least one coronary artery of ≥ 2 mm on CCTA, to FFRct-guided care or usual care in a 1:1 ratio. Follow-up will be 1 year. The primary endpoint is the rate of unnecessary invasive coronary angiography within 90 days.

Conclusion
The FUSION trial will evaluate the use of FFRct in stable chest pain patients from the Dutch perspective. The trial is funded by the Dutch National Health Care Institute as part of the research programme ‘Potentially Promising Care’ and the results will be used to assess if FFRct reimbursement should be included in the standard health care package.
A design strategy for water-based noise suppression systems in liquid rocket engines firing tests
Authors: Zolla Paolo Maria , Fiore Matteo , Lapenna Pasquale Eduardo , Bianchi Daniele , Nasuti Francesco 
Published: August 2022

AbstractThis paper presents a streamlined design procedure for water-based noise suppression systems that are applicable to multiple classes of rocket engines. A newly adapted steady quasi-one-dimensional two-phase model is employed to predict the evolution of the exhaust gases interacting with water droplets. Such a model is embedded into a two-step optimization procedure with the objective of finding the most efficient combination of the suppressor operative parameters. This information is then used to design the hardware of the system, which consists in a set of injectors, with the task of producing atomized water jets directed towards the exhaust gases, and a toroidal manifold, with the task of delivering water to the injectors at uniform conditions of pressure and velocity. Finally, the proposed design procedure is applied to a 15 kN thrust class oxygen/methane liquid rocket engine. Technical specifications of the resulting water-based noise suppression system are provided along with a detailed three-dimensional CAD model.
Comparative Study of the Neurotoxic Effects of Pregabalin Versus Tramadol in Rats
Authors: Elsukary Ahmed E. , Helaly Ahmed M. N. Z. , El Bakary Amal A. , Moustafa Maha E. , El-Kattan Mohammad A. 
Published: August 2022

AbstractIn Egypt, both pregabalin and tramadol misuse increased in the last decade. Although many studies have confirmed the neurotoxic effects of tramadol, those of pregabalin are understudied. The aim of the study is to evaluate the neurotoxic effects of pregabalin compared with tramadol. Thirty male albino rats were included in this experimental study, and they were randomly allocated into three equal groups: group I (normal saline), group II (tramadol misuse), and group III (pregabalin misuse). All rats received the commenced drugs for 1 month. Open field tests were performed on the day of scarification, and after that, cortical samples were taken for immunohistochemical analysis and quantification of dopamine receptors’ gene expression. The drug misuse groups showed a significant decrease in weight gain at the end of the study. Open field testing showed the upper hand of controls regarding all of the tested parameters. Tramadol has a more negative impact on the locomotor parameters compared with pregabalin. Both drugs induced relatively low dopamine-1 receptor (D1Rs) expression to dopamine-2 receptors (D2Rs), mimicking the schizophrenia model. Both tramadol and pregabalin were associated with neurotoxic effects in male albino rats. These effects were less noticed with pregabalin. It is suggested that long-term abuse may end in psychosis.
Transcriptome-derived SSR markers for DNA fingerprinting and inter-populations genetic diversity assessment of Atractylodes chinensis
Authors: Ma Shanshan , Zhao Jianhua , Su Wennan , Zheng Jinshuang , Zhang Sai , Zhao Wenjun , Su Shuyue 
Published: August 2022

AbstractAtractylodes chinensis (fam. Asteraceae) is an important medicinal plant due to its unique pharmacological activity. The species is widely distributed in most areas of northern China. It is difficult to identify different populations of A. chinensis due to their similarity in characteristics. This study was the first investigation to date that assessed the genetic diversity of A. chinensis from different geographical counties of northern China using simple sequence repeat (SSR) markers. Of the 106 SSR primers in the clusters classified in the sesquiterpenoid biosynthesis pathway in the transcriptomic database of A. chinensis, ten with high polymorphism were used to analyze the inter-populations genetic diversity and construct DNA fingerprinting of 19 A. chinensis populations. A total of 78 alleles were detected, with an average number of 6.5 alleles per primer. The PIC value ranged from 0.4748 to 0.8918 with a mean of 0.6265. The neighbor-joining tree was used to classify 19 populations of A. chinensis into three clusters. DNA fingerprinting was performed according to these ten SSR markers. The results revealed that geographic origin is not exactly related to genetic diversity, as populations belonging to different provinces are grouped in the same cluster. The results of this study confirm that SSR markers are effective for genetic diversity analysis. The inter-populations genetic diversity and fingerprinting of A. chinensis in this study could provide a scientific basis for species identification and selective breeding.
Indocyanine green fluorescence in robot-assisted minimally invasive esophagectomy with intrathoracic anastomosis: a prospective study
Authors: de Groot E. M. , Kuiper G. M. , van der Veen A. , Fourie L. , Goense L. , van der Horst S. , van den Berg J. W. , van Hillegersberg R. , Ruurda J. P. 
Published: August 2022

AbstractIndocyanine green fluorescence angiography (ICG-FA) allows for real-time intraoperative assessment of the perfusion of the gastric conduit during esophagectomy. The aim of this study was to investigate the effect of the implementation of ICG-FA during robot-assisted minimally invasive esophagectomy (RAMIE) with an intrathoracic anastomosis. In this prospective cohort study, a standardized protocol for ICG-FA was implemented in a high-volume center in December 2018. All consecutive patients who underwent RAMIE with an intrathoracic anastomosis were included. The primary outcome was whether the initial chosen site for the anastomosis on the gastric conduit was changed based on ICG-FA findings. In addition, ICG-FA was quantified based on the procedural videos. Out of the 63 included patients, the planned location of the anastomosis was changed in 9 (14%) patients, based on ICG-FA. The median time to maximum intensity at the base of the gastric conduit was shorter (25 s; range 13–49) compared to tip (34 s; range 12–83). In patients with anastomotic leakage, the median time to reach the FImax at the tip was 56 s (range 30–83) compared to 34 s (range 12–66) in patients without anastomotic leakage (p = 0.320). The use of ICG-FA resulted in an adaptation of the anastomotic site in nine (14%) patients during RAMIE with intrathoracic anastomosis. The quantification of ICG-FA showed that the gastric conduit reaches it maximum intensity in a base-to-tip direction. Perfusion of the entire gastric conduit was worse for patients with anastomotic leakage, although not statistically different.
Pearson equations for discrete orthogonal polynomials: III—Christoffel and Geronimus transformations
Authors: Mañas Manuel 
Published: August 2022

AbstractContiguous hypergeometric relations for semiclassical discrete orthogonal polynomials are described as Christoffel and Geronimus transformations. Using the Christoffel–Geronimus–Uvarov formulas quasi-determinantal expressions for the shifted semiclassical discrete orthogonal polynomials are obtained.
Use of N-Methylmorpholine N-oxide (NMMO) pretreatment to enhance the bioconversion of lignocellulosic residues to methane
Authors: Oliva A. , Tan L. C. , Papirio S. , Esposito G. , Lens P. N. L. 
Published: August 2022

AbstractLignocellulosic residues (LRs) are one of the most abundant wastes produced worldwide. Nevertheless, unlocking the full energy potential from LRs for biofuel production is limited by their complex structure. This study investigated the effect of N-methylmorpholine N-oxide (NMMO) pretreatment on almond shell (AS), spent coffee grounds (SCG), and hazelnut skin (HS) to improve their bioconversion to methane. The pretreatment was performed using a 73% NMMO solution heated at 120 °C for 1, 3, and 5 h. The baseline methane productions achieved from raw AS, SCG, and HS were 54.7 (± 5.3), 337.4 (± 16.5), and 265.4 (± 10.4) mL CH4/g VS, respectively. The NMMO pretreatment enhanced the methane potential of AS up to 58%, although no changes in chemical composition and external surface were observed after pretreatment. Opposite to this, pretreated SCG showed increased porosity (up to 63%) and a higher sugar percentage (up to 27%) after pretreatment despite failing to increase methane production. All pretreatment conditions were effective on HS, achieving the highest methane production of 400.4 (± 9.5) mL CH4/g VS after 5 h pretreatment. The enhanced methane production was due to the increased sugar percentage (up to 112%), lignin removal (up to 29%), and loss of inhibitory compounds during the pretreatment. An energy assessment revealed that the NMMO pretreatment is an attractive technology to be implemented on an industrial scale for energy recovery from HS residues.
Punica granatum peel extract mediated green synthesis of zinc oxide nanoparticles: structure and evaluation of their biological applications
Authors: Shaban Abdelghany S. , Owda Medhat E. , Basuoni Mostafa M. , Mousa Mohamed A. , Radwan Ahmed A. , Saleh Ahmed K. 
Published: August 2022

Abstract
The green synthesis of zinc oxide nanoparticles (ZnO-NPs) mediated fruit peel extract is gaining importance due to its cost-effectiveness and ecofriendly nature. Herein, ZnO-NPs were synthesized using pomegranate peel extract as a reducing and stabilizing agent. The synthesized ZnO-NPs were characterized using SEM, TEM-SAID, FT-IR, XRD, and particle size analysis. According to the findings, the ZnO-NPs were agglomerated into spherical and hexagonal shapes with an average diameter of 20 to 40 nm and crystallinity formed. The antimicrobial activity of ZnO-NPs against pathogenic microbes was significant in multiple applications, with 62.5 and 31.25 μg/ml of MIC for both Gram-positive and Gram-negative bacteria, respectively, and 125 and 250 μg/ml of MIC for Aspergillus niger and Aspergillus flavus, respectively. In addition, ZnO-NPs showed antioxidant activity with IC50 = 240 and 250 μg/ml by DPPH and ABTS, respectively. All concentrations of ZnO-NPs significantly improved the germination of barley seed and shoot height, with the optimum concentration reaching 2 and 12 ppm of ZnO-NPs for both seed germination (90%) and shoot height (6.5), respectively, while the greatest root extension (6 cm) was observed at 2 ppm of ZnO-NPs. The mitotic index increased at lower nanoparticle concentrations and exposure times but declined considerably as the nanoparticle dose and exposure duration increased, until most concentrations reached 100% suppression after 12 h with various chromosomal abnormalities. The researchers were able to create efficient, eco-friendly, and simple multifunctional ZnO-NPs using a green synthetic strategy and, in the process, obtain a better understanding of the cytotoxicity and genotoxicity of ZnO-NPs in plant cells.
Simulation research of a counter-flow rotary kiln hazardous waste incineration system
Authors: Yang Shiqiao , Kong Qingfeng , Zeng Dewang , Wu Shiliang , Gong Feng , Xiao Rui 
Published: August 2022

AbstractAs industrialization accelerates and the amount of hazardous waste generated gradually increases, the means of disposal of hazardous waste is of increasing concern. In this paper, a 40 t/d counter-flow rotary kiln incineration system owned by a Jiangsu environmental protection company was researched. The software Aspen Plus was used to build the mixed pyrolysis model and the software Fluent was used to build the computational fluid dynamics model of the incineration system. The influence of the calorific value of the hazardous waste, the operating temperature and the air supply on the operational effectiveness of the incineration system were analyzed by varying the simulation conditions. The results show that the SOx and NOx content of the product is lower when the operating temperature is above 800 °C. The incineration system could only operate above 800 °C when the calorific value of the hazardous waste is not less than 1500 kcal/kg. The incineration system operated best at a primary air velocity of 1.5 m/s. The simulation results in this paper serve as a guide for the operation of counter-flow rotary kiln incineration systems.
Interface Formation of Zinc-Rich ZnAlCu Bearing Alloys on Pre-galvanized S355 Steel Substrates in Gravity Die Casting
Authors: Gimmler Steffen , Vroomen Uwe , Bührig-Polaczek Andreas 
Published: August 2022

AbstractThe dependence of the interfacial formation of ZnAlCu alloys on S355 steel substrates on the aluminum content of the alloy and the cooling conditions is investigated for the gravity die casting process. Steel substrates pre-galvanized with ZnAl0.2 as well as with ZnAl5 are used as initial condition. The area fractions of the interfacial phases formed in the process are quantitatively determined by a binarization method and correlated with the compositions and the casting conditions in simple mathematical models. Under the test conditions, especially for hypoeutectic alloy variants with a maximum of 5.5 wt% Al, clear dependencies of the phase fractions in the interfacial formation on the aluminum content, but also on the cooling conditions could be demonstrated. The correlations of the forming phases with the type of pre-galvanization could also be shown over a wide range of compositions and solidification rates.