bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capacity enhancement in fiber optic communication systems using space division multiplexing
Authors: Gelmecha Demissie Jobir , Goshu Gammachu Namara , Ayane Tadesse Hailu , Singh Ram Sewak 
Published: December 2022

Abstract
Data rates in fiber optic communication (FOC) technology are highly increased and optical communication technology has been mostly advancing highly. There are different multiplexing techniques like frequency-division multiplexing (FDM), time-division multiplexing (TDM), wavelength division multiplexing (WDM), dense wavelength division multiplexing (DWDM), code division multiplexing (CDM), and digital coherent technology by using single mode fiber (SMF)/single core fiber (SCF), and using these multiplexing did not produce over 100 Tbps/fiber because of many factors like linearity and nonlinearities of fiber optic. To transmit a high capacity over 100 Tbps/fiber and long-haul transmission, the multiplexing techniques that are needed to break this bottleneck/capacity limit are termed space-division multiplexing, which uses single mode fiber (SMF) and multicore fiber (MCF). The target of this paper is to enhance the capacity of FOC systems using space-division multiplexing (SDM). The result produced during this paperwork is that the capacity enhanced is around 14.75 pb/s/fiber, after it is decreasing and thus the haul of transmission is 250 km with usable wavelength C + L band. The signal/noise ratio is 35 dB in FOC using single mode fiber (SMF) and multicore fiber (MCF). Finally, the SDM includes a great role in fiber optic just in case of effective information transmission by enhancing capacity, reduction of loss, distortion, cross talk, and power consumption reduction during information transmission; SDM in fiber optic is incredibly essential for effective communication systems with extremely high capacity and long haul transmission.
Recovery of Cr from chrome-containing leather wastes to develop aluminum-based composite material along with Al2O3 ceramic particles: An ingenious approach
Authors: Dwivedi Shashi Prakash , Petru Michal , Saxena Ambuj , Sharma Shubham , Mishra Madhulika , Pramanik Alokesh , Singh Sunpreet , Li Changhe , Ilyas Rushdan Ahmad 
Published: December 2022

Abstract
Leather industries cause soil pollution in terms of leather wastes. Chrome-containing leather wastes (CCLW) also cause various types of pollutions such as air and soil pollution. The utilization of CCLW in the development of aluminum-based composite is the emerging area in the synthesis of materials. In this study, chromium(Cr) in the form of collagen powder was extracted from CCLW. Extracted collagen powder was ball milled with alumina particles for 12.5, 25, 50, 75, and 100 h. The average density of the mixture of ball-milled collagen and alumina particles was reduced by about 1.20% after ball milling for about 100 h. The stir casting technique was employed to develop the aluminum-based composite material. The ball-milled reinforced aluminum-based composite material showed a fair distribution of reinforcement particles as compared without ball-milled reinforced composite material. Tensile strength and hardness of composite material improved by about 35.53 and 46.61%, respectively, after using the mixture of ball-milled 5% collagen powder and 5% alumina particles in the aluminum alloy. However, ductility and toughness were reduced. Corrosion weight loss and thermal expansion of the Al/5% collagen/5% alumina particles with ball-milled composite were found to be 0.022 mg and 5.44 mm3, respectively. X-Ray diffraction of the Al/5% collagen/5% alumina particles with ball-milled composite showed the presence of Al, Al2O3, Cr2O3, and Cr phases. The presence of hard phases such as Al2O3, Cr2O3, and Cr was responsible for enhancing the hardness and tensile strength of the composite. The developed composite material can be utilized in the fabrication of engine blocks, connecting rods, and piston rings.
Effects of Concurrent Resistance and Endurance Training Using Continuous or Intermittent Protocols on Muscle Hypertrophy: Systematic Review With Meta-Analysis
Authors: Monserdà-Vilaró Aniol , Balsalobre-Fernández Carlos , Hoffman Jay R. , Alix-Fages Carlos , Jiménez Sergio L. 
Published: December 2022

Abstract
Monserdà-Vilaró, A, Balsalobre-Fernández, C, Hoffman, JR, Alix-Fages, C, and Jiménez, SL. Effects of concurrent resistance and endurance training using continuous or intermittent protocols on muscle hypertrophy: Systematic review with meta-analysis. J Strength Cond Res 37(3): 688–709, 2023—The purpose of this systematic review with meta-analysis was to explore the effects of concurrent resistance and endurance training (CT) incorporating continuous or intermittent endurance training (ET) on whole-muscle and type I and II muscle fiber hypertrophy compared with resistance training (RT) alone. Randomized and nonrandomized studies reporting changes in cross-sectional area at muscle fiber and whole-muscle levels after RT compared with CT were included. Searches for such studies were performed in Web of Science, PubMed, Scopus, SPORTDiscus, and CINAHL electronic databases. The data reported in the included studies were pooled in a random-effects meta-analysis of standardized mean differences (SMDs). Twenty-five studies were included. At the whole-muscle level, there were no significant differences for any comparison (SMD < 0.03). By contrast, RT induced greater type I and type II muscle fiber hypertrophy than CT when high-intensity interval training (HIIT) was incorporated alone (SMD > 0.33) or combined with continuous ET (SMD > 0.27), but not compared with CT incorporating only continuous ET (SMD < 0.16). The subgroup analyses of this systematic review and meta-analysis showed that RT induces greater muscle fiber hypertrophy than CT when HIIT is included. However, no CT affected whole-muscle hypertrophy compared with RT.
Ambivalence, Estrangement, and Opacity
Authors: Keohane Kate 
Published: December 2022

In the wake of Paul Gauguin’s artistic practice, this essay interrogates the work of contemporary visual practitioners who have sought to challenge the legacy of colonial modes of framing through performative engagements with notions of the artistic journey and issues of landscape. A photographic series by Guy Tillim, a film collaboration by Rosalind Nashashibi and Lucy Skaer, a painting by Michael Armitage, and a video work by Tiare Ribeaux point to the possibilities for engaging with the un-seeability and un-sayability of landscape through visual culture. Proposing critical interpretations of the significance of landscape as genre, these four bodies of work allow for conversations around the postcolonial effectivity of specific media, as well as the contradictory subject positions inherent to interactions premised upon conceptions of “return.”
The works, titled Second Nature (2010–11), Why Are You Angry? (2017), Paradise Edict (2019), and Ulu Kupu (2022) respectively, offer methods for approaching and critiquing complex and problematic transnational engagements, as well as foregrounding the need for Pan-Oceanic approaches. In line with the theorizations of Epeli Hau’ofa, who argues that Oceanic identity should take a regional form, defined by movements and proximity within the expansive Pacific Ocean, these artists attempt to visualize the complexities of conveying a place as simultaneously lived and imagined. In particular, the projects reckon with the difficulty of engaging with the familiar tropisms that define tropical spaces within the cultural imaginary and attempt to offer heterochronic modes of showing and circulating issues of geographical, botanical, and cultural heritage.
In planta genetic transformation to produce CRISPRed high-oleic peanut
Authors: Han Hong Wei , Yu Shu Tao , Wang Zhi Wei , Yang Zhen , Jiang Chun Jiao , Wang Xiu Zhen , Sun Xiu Shan , Wang Chuan Tang 
Published: December 2022

Abstract
In contrast to its normal-oleic counterpart, high-oleic peanut has better keeping quality and multiple health benefits. Breeding high-oleic peanut through conventional means is a tedious process generally requiring several years. Genome editing, however, may shorten the duration. In this study, node injection method was used to transform normal-oleic Huayu 23, a popular peanut cultivar having dysfunctional FAD2A and functional FAD2B, with CRISPR/Cas9 construct targeting FAD2B, and two T0 seeds with over 80% oleic acid and 442A insertion in FAD2B were obtained. A T1 plant grown from the viable T0 seed produced high-oleic seeds. As a genotype-independent, simple and easy method for peanut genetic transformation, node injection has great potential in functional analysis of genes and peanut varietal improvement.
Long-term Administration of CU06-1004 Ameliorates Cerebrovascular Aging and BBB Injury in Aging Mouse Model: A Randomized Control Trial
Authors: Kim Hyejeong , Noh Minyoung , Zhang Haiying , Kim Yeomyeong , Park Songyi , Park Jeongeun , Kwon Young-Guen 
Published: December 2022

Abstract

Background:Age-related changes in the cerebrovasculature, including blood-brain barrier (BBB) disruption and vascular dementia are emerging as potential risks for many neurodegenerative diseases. Therefore, endothelial cells that constitute the cerebrovasculature play a key role in preventing brain injury. Our previous study showed that CU06-1004, endothelial cell dysfunction blocker, prevented vascular leakage and enhanced vascular integrity in ischemic reperfusion injury and normalization of tumor vasculature. Here, we evaluate the effects of CU06-1004 on age-related decline in cerebrovascular function of aged mice brain.Results:In this study, we investigated the protective effects of CU06-1004 on reducing oxidative stress-induced damage in human brain microvascular endothelial cells (HBMECs). HBMECs were treated with hydrogen peroxide (H2O2) to establish an oxidative stress-induced cellular injury model. Pretreatment with CU06-1004 considerably reduced oxidative stress-induced cytotoxicity, ROS generation, senescence-associated β-galactosidase activity, and senescence markers in HBMECs. Additionally, pretreatment with CU06-1004 decreased the expression levels of inflammatory proteins, compared to H2O2treatment alone. Based on the cytoprotective effect of CU06-1004 in HBMECs, we further examined the vascular protective effects of CU06-1004 on cerebrovascular aging in aged mice. Long-term administration of CU06-1004 alleviated age-associated cerebral microvascular rarefaction and cerebrovascular senescence in the aged mouse brain. CU06-1004 supplementation also reduced extravasation of plasma IgG by improving BBB integrity in the aged mouse brain. This improvement in BBB integrity was associated with reduced neuronal injury and cognition memory dysfunction in aged mice. A series of behavioral tests revealed improved motor and cognitive function in aged mice that received CU06-1004.Conclusion:These findings suggest CU06-1004 has promise as a therapeutic for delaying age-related cerebrovascular impairment and improving cognitive function in old age.
Can Green finance, green technologies, and environmental policy stringency leverage sustainability in China: Evidence from Quantile-ARDL estimation.
Authors: Afshan Sahar , Yaqoob Tanzeela , Meo Muhammad Saeed , Hamid Bushra 
Published: December 2022

Abstract
The prime objective of this study is to examine empirically the role of green finance, eco-innovation, and environmental policy stringency to leverage sustainability in China. In doing so, the current study employs the novel QARDL approach using annual data ranging from 2000 to 2017. The study's findings support the existence of a heterogeneous association between the proposed variables. Precisely, the results of QARDL estimation demonstrate that there is a negative association between eco-innovation and ecological footprints; however, the extent of the relationship is quantile dependent. We also discovered an asymmetric negative and significant relationship between green finance and ecological footprints, with findings indicating that a 1% increase in green finance at low quantiles can reduce ecological footprints by 1–4%. However, a 1% increase in green finance at extreme high quantiles leads to a 7% decrease in ecological footprints. Also, for environmental policy stringency, we confirmed that a 1% increase in environmental policy stringency at high quantiles results in a 5–8% reduction in ecological footprints. Finally, the current study offers policymakers helpful suggestions on how to enhance the positive effects of environmentally supported innovation, green finance and stringent environmental policies on the ecosystem.
Comparison the application of 18 F-FDG and 68 Ga-DOTATATE PET/CT in neuroendocrine tumors: A retrospective study
Authors: Hu Xianwen , Li Dandan , Wang Rui , Wang Pan , Cai Jiong 
Published: December 2022

Abstract
Objective: This study aims to compare the efficacy of 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT imaging in the diagnosis, staging and prognosis evaluation of neuroendocrine tumors (NET).
Methodes: We retrospectively reviewed 55 patients (43 patients were initially evaluated; 12 patients were evaluated after treatment) who underwent 18F-FDG and 68Ga DOTATE PET/CT examinations and had pathological results.
Results: In the initial evaluation of 43 patients, 27 patients were pathologically confirmed as NET patients, 23 of which were correctly detected by 18F-FDG, and all 27 patients were detected by 68Ga-DOTATATE. On lession-based comparison, 119 and 168 focal lesions were depicted on 18F-FDG PET/CT and 68Ga-DOTATATE PET/CT, respectively (p =0.0363). In all patients, 68Ga-DOTATATE has higher SUVmax than 18F-FDG, and the SUVmax is negatively related to the NET grade for the former, while the latter is positively related to it.
Conclusion: The value of 68Ga-DOTATATE PET/CT in the diagnosis and staging of NET is higher than that of 18F-FDG PET/CT in NETs, while the value of 18F-FDG PET/CT in NET cannot be ignored, and the combined application of two tracers has important clinical significance for the management of patients with NET.
Health Effects and Clean Up Costs of Love Canal in Niagara Falls, New York
Authors: zelaalem mengistu 
Published: December 2022

Abstract
The Love Canal is a hazardous waste dump-site located in the center of a middle class community in Niagara Falls, New York" which was used as municipal and chemical waste disposal area for residue from the manufacture of chlorinated hydrocarbons from the 1920s until 1953 when it was covered with earth. Perhaps because they didn’t understand the potential risks associated with Hooker’s chemical wastes primary schools and homes had been constructed around the canal .The tragedy of Love Canal were damaged countless families and ruined the environment for many years. The toxic contamination found throughout the soil brought emotional as well as physical pain to those who had purchased homes in the Love Canal area or who had sent their children to its school system. The various additional substances discovered at Love Canal produce a range of acute, sudden symptoms as well as chronic or long term health problems. Proper disposal of hazardous waste is important in protecting the public health. Site selection and site preparation are important factors to be considered for hazardous waste disposal. Overall, the chemical cleanup process is time consuming and costly and this is why it is so important to dispose of toxic waste in proper facilities where the substances will not come into contact with people and pollute their land and water supplies.
Lateral Distal Femoral Condyle as a Precise Reference for Distal Femoral Resection in Total Knee Arthroplasty for Severe Varus Knee Osteoarthritis
Authors: Wei Maozheng , Hao Kuo , Kang Huijun , Kong Lingce , Wang Fei 
Published: December 2022

Abstract
Purpose

Bone resection was highly valued in total knee arthroplasty (TKA), but how to determine the amount of distal femur resection is still controversial. The purpose of this study was to explore how to use lateral condyle as a reference for distal femoral osteotomy in TKA.

Method

Imaging data from 118 nonarthritic subjects and 123 osteoarthritis (OA) subjects were used to assess the cartilage wear pattern of the distal femur in varus knees. Measurements were performed on three-dimensional reconstruction after virtual bone cutting. The difference between the resection amount of distal (0°) and posterior (90°) was calculated when the medial condyle was used as a reference in OA patients. The osteotomy amount on lateral was calculated in nonarthritic subjects when the medial condylar osteotomy was consistent with the thickness of the implants.

Results

In 43% of OA patients, there was༞1mm difference between the 0° and 90° in medial condyle cartilage, and no difference was observed in lateral. When using medial condyle as a reference for osteotomy, there was a difference of 1.3 ± 0.56 mm between the resection amount of 0° and 90°, and the difference was 0.24 ± 0.27 mm when using lateral condyle. Statistical analysis showed that there was a linear correlation between the resection amount of lateral condyle and mechanical lateral distal femoral angle (mLDFA) in nonarthritic subjects (R = 0.72, p<0.001).

Conclusions

Using the lateral condyle as the reference for distal femoral osteotomy is more suitable for the cartilage wear pattern of the varus knee. The position of cutting guide can be adjusted by preoperative measurements of mLDFA.
Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of modulating CD1a-mediated T cell responses
Authors: Kobiela Adrian , Hewelt-Belka Weronika , Frąckowiak Joanna E , Kordulewska Natalia , Hovhannisyan Lilit , Bogucka Aleksandra , Etherington Rachel , Piróg Artur , Dapic Irena , Gabrielsson Susanne , Brown Sara J , Ogg Graham S , Gutowska-Owsiak Danuta 
Published: December 2022

Abstract

The promoting effect ofFLGloss-of-function mutations on the development of atopic dermatitis (AD) signifies the role of filaggrin in the formation of a protective skin barrier;FLGmutations are also linked to asthma, food allergy and allergic rhinitis despite the absence of the protein in the affected tissues (lungs, intestines, and the majority of the nasal mucosa). AD patients suffer from chronic inflammation and recurrent skin infections; inflammation often precedes the appearance of spatially distant allergic manifestations. Here we show that exosome-enriched small extracellular vesicles (sEVs) secreted by filaggrin-knockdown keratinocytes are extensively remodelled as a consequence of the abnormal keratinocyte differentiation process. This alteration modulates the sEV capacity to promote type 1 and type 2 CD1a-dependent T cell responses by direct effects on self-lipid neoantigen generation; both modulating the amount of permissive (stimulatory) and non-permissive (inhibitory) CD1a ligands released from the sEV membranes by phospholipase A2. We found that this aberrant sEV lipid composition reflects a generalised cellular lipid bias with downregulation of multiple enzymes of lipid metabolic pathways, observed both in filaggrin knockdown keratinocytesin vitro, and in the skin of AD patients. Provision of modulatory ligands by sEVs secreted on a filaggrin insufficiency background, impeding both homeostatic autoreactive and protective antimicrobial CD1a-mediated type 1 and enhancing type 2 T cell responses provides basis for reduced tissue integrity and pathogen clearance and perpetuates inflammation in AD skin as well as in distant tissues to which sEVs are transferred by systemic circulation.
MULTİPL SKLEROZLU BİREYLERDE STABİLİTE LİMİTLERİ VE DÜŞME RİSKİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: ÖZVAR Güngör Beyza , AYVAT Ender , KILINÇ Muhammed 
Published: December 2022

Amaç: Bu çalışmanın amacı, Multipl Skleroz (MS)’lu bireylerde stabilite limitleri (SL) ile düşme riski arasındaki ilişkiyi incelemektir.
Yöntem: Çalışmaya 18-50 yaş aralığında, Expanded Disability Status Scale (EDSS) skoru ≤ 4, son 6 ay içerisinde atak geçirmeyen ve son 6 ay içerisinde düşme hikâyesi olan 30 MS’li birey dâhil edildi. Bireylerin demografik bilgileri kaydedildi. Dört yöndeki (anterior, posterior, lateral- sol, sağ) SL, Bertec Balance Check ScreenerTM (Model BP5050; Bertec Corporation, Columbus, OH, USA) ile değerlendirildi. Düşme riski ise Zamanlı Kalk ve Yürü Testi (ZKYT) ile değerlendirildi. Dört yöndeki SL ile ZKYT skoru arasındaki ilişkileri incelemek için Spearman korelasyon testi kullanıldı.
Sonuçlar: Çalışmaya katılan 30 bireyin (18 kadın, 12 erkek) yaş ortalaması 37,66±8,86 yıl idi. Anterior-posterior SL ile ZKYT skorları arasında negatif yönde iyi derecede (r =-0,616), lateral solsağ SL ile ZKYT skorları arasında negatif yönde orta derecede (r =-0,463) anlamlı bir ilişki bulundu (p
Artificial Intelligence Assisted Fabrication of 3D, 4D and 5D Printed
Formulations or Devices for Drug Delivery
Authors: Sharma Kiran Singh 
Published: December 2022

Abstract:
5D & 4D printings are an advanced version of 3D printing class and are one of the most
revolutionary and powerful fabrication methods used for preparing innovative structures and solid substances
using precise additive manufacturing technology. It captures the imagination of one with its
potential to produce flexible designing and fabrication of innovative products with high complexity and
speed. This technology with the assistance of AI (Artificial Intelligence) facilitates real-time sensing,
adapting to change, and predicting the state of printing. 3D printing works by employing advanced materials
utilizing a computer aided design with tomography scan under AI control which deposits printing
material in accordance with the nature of a file usually in STL format, but it requires time for printing.
This shortcoming can be overcome by 4D printing where smart materials are incorporated with time as
4th dimension. This technique has self-repair and self-assembly properties that will save around 80% of
time. Some printed materials are made sensitive to temperature, humidity, light, and other parameters so
that they can respond to stimulus, but it’s one limitation of not being able to print complex shapes having
curved surfaces can be overcome by utilising 5D printing where additive manufacturing is done by
rotation of extruder head and rotation of print bed to print in 5 different axes. This review evaluates the
prospective of these techniques with AI interference in medicine and pharmacy, with its effective and
efficient production for the required design precision.
Chemical Modifications of Pyridoxine for Biological Applications: An
Overview
Authors: Sharma Abha , Pawar Rajashree , Chaudhran Preeti , Pandey Dheeraj 
Published: December 2022

Abstract:
Pyridoxine and its derivatives, pyridoxamine, and pyridoxal have been recognized for more than 70 years and are known for regulating cellular biology and metabolism. During the past few decades, the anti-oxidant and anti-inflammatory properties of pyridoxine and its vitamers were explored. However, an interesting turnabout was observed in pyridoxine chemical modification in the last two decades. The various important pathophysiological aspects of pyridoxine and its deriva-tives on several cellular systems have been discovered by researchers. Recent findings have shown that many diseases, like cancer, diabetes, hypertension, tuberculosis, epilepsy, and neurodegenera-tive diseases are linked to the alteration of pyridoxine. Herein, our main focus is to review the im-portance of pyridoxine and its derivatives obtained by various chemical modifications, in various disease areas and to recognize important directions for future research.