bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel thermal treatment model to decontaminate airborne SARS Cov‐2 virus for residential and commercial buildings
Authors: Soni Neelesh , Hanmaiahgari Prashanth R. , Reddy V. Mahendra 
Published: May 2022

AbstractIn the COVID‐19 pandemic, control of airborne virus transmission is exceptionally challenging as it is attached to suspended particles in the air and stays for an extended time. Air contaminated with airborne viruses holds a substantial risk for household transmission. In this study, a novel thermal treatment system is modeled based on porous heating for the decontamination of airborne SARS‐Cov‐2. The model includes an air heating domain, insulated chamber, buffer tank and heat exchanger. The airborne SARS‐Cov‐2 is decontaminated when passing through a porous heat pipe and the insulated chamber for an anticipated dwelling period of more than 5 min at 105°C and further stored in a buffer tank for natural cooling. The obligatory decontaminated air is allowed in the residential space under ambient conditions passing through a heat exchanger. The numerical investigation of the porous pipe model at different L/D ratios with altered porosities aims to establish the best‐performing porous domain. Besides this, the buffer tank is intended to maintain buffer storage of the treated air and significant natural cooling before passing to the heat exchanger. A solar PV module is proposed to meet the prerequisite energy requirements of the equipped devices.
When to use a cookie, and when to use a ruler: A response to Byers‐Heinlein, Bergmann and Savelei's “six solutions for more reliable infant research”
Authors: Flack Zoe M. , Skelton Alice E. 
Published: May 2022

AbstractHere, we provide a response of broad agreement to the authors' six suggestions for improving the reliability of infant research. We also draw attention to three points we feel are important additions. We discuss the importance of considering measurement validity alongside measurement reliability as both contribute to overall measurement error, as well as emphasizing the selection of methods that are theory driven and balancing this with the need for precise or accurate measures. We also briefly discuss how differences in training, access to resources and other factors can influence choices of method and analysis. Sometimes, simple is good enough.
Probing combinational influence of design variables on bone biomechanical response around dental implant‐supported fixed prosthesis
Authors: Chakraborty Arindam , Datta Pallab , Kumar Cheruvu Siva , Majumder Santanu , Roychowdhury Amit 
Published: May 2022

AbstractThis study aimed to understand the effect of physiological and dental implant‐related parameter variations on the osseointegration for an implant‐supported fixed prosthesis. Eight design factors were considered (implant shape, diameter, and length; thread pitch, depth, and profile; cantilever [CL] length and implant‐loading protocol). Total 36 implantation scenarios were simulated using finite element method based on Taguchi L36 orthogonal array. Three patient‐specific bone conditions were also simulated by scaling the density and Young's modulus of a mandible sample to mimic weak, normal, and strong bones. Taguchi method was employed to determine the significance of each design factor in controlling the peri‐implant cortical bone microstrain. For normal bone condition, CL length had the maximum contribution (28%) followed by implant diameter (18%), thread pitch (14%), implant length (8%), and thread profile (5%). For strong bone condition, CL and implant diameter had equal contribution (32%) followed by thread pitch (7%) and implant length (5%). For weak bone condition, implant diameter had the highest contribution (31%) followed by CL length (30%), thread pitch (11%) and implant length (8%). The presence of distal CL in dental framework was found to be the most influential design factor, which can cause high strain in the cervical cortical bone. It was seen that implant diameter had more effect compared to implant length toward peri‐implant bone biomechanical response. Implant‐loading time had no significant effect towards peri‐implant bone biomechanical response, signifying immediate loading is possible with sufficient mechanical retention.
circ_0004872 inhibits proliferation, invasion, and glycolysis of oral squamous cell carcinoma by sponged miR‐424‐5p
Authors: Dai Yinhua , Zhu Yalin , Xu Houyi 
Published: May 2022

AbstractObjectiveOral squamous cell carcinoma (OSCC) is one of the most common oral malignant tumors. circ_0004872 can inhibit the progression of gastric cancer, but its effect on the growth and metastasis of OSCC is still unclear.MethodsqRT‐PCR was used to detect the expression levels of circ_0004872 and miR‐424‐5p in cancer tissues of OSCC patients and adjacent normal tissues, OSCC cell lines, and human normal oral keratinocytes (HOK). CCK‐8, cell colony formation, flow cytometry, and transwell assay were used to detect cell proliferation rate, viability, apoptosis rate, and invasion ability. Use glucose/lactic acid kit to assay cell glycolysis ability. The dual‐luciferase reporter gene experiment and RIP experiment verified the relationship between circ_0004872 and miR‐424‐5p. The protein levels were examined by Western blot.ResultsThe expression of circ_0004872 was significantly downregulated in OSCC tissues and cells, and the overexpression of circ_0004872 inhibited the proliferation, vitality, invasion, and glycolysis of OSCC cells, and promoted apoptosis. The expression of miR‐424‐5p was greatly upregulated in OSCC tissues and OSCC cells. circ_0004872 can adsorb miR‐424‐5p in OSCC cells, and circ_0004872 can reverse the promoting effect of miR‐424‐5p overexpression on the process of OSCC cells.Conclusioncirc_0004872 suppresses the proliferation, invasion, and glycolysis of OSCC cells by sponged miR‐424‐5p, and promotes apoptosis, which can be used as a potential target for early diagnosis and targeted therapy of OSCC.
Determination of fipronil and its metabolites in environmental water samples by meltblown nonwoven fabric‐based solid‐phase extraction combined with gas chromatography‐electron capture detection
Authors: Zhao Qin , Yue Shi‐Wen , Zhou Yi‐Lian , Yang Jin‐Jie 
Published: May 2022

In this study, a new method for the determination of fipronil and its three metabolites in environmental water samples was developed based on meltblown nonwoven fabric solid‐phase extraction combined with gas chromatography‐electron capture detection. As the core material of medical masks, meltblown nonwoven fabric is made of polypropylene superfine fibers which are randomly distributed and bonded together with a relatively large specific surface area and good permeability. Polypropylene as a high molecular hydrocarbon‐based polymer has the characteristics of good hydrophobicity and lipophilicity, which can be applied for the separation and enrichment of hydrophobic substances in food, environment, and biological samples. The meltblown nonwoven fabric is soft and can fill the solid‐phase extraction cartridge tightly. This aspect also makes it suitable to be used as an ideal solid‐phase extraction sorbent. A series of parameters influencing the extraction efficiency were investigated, and under the optimized conditions, fipronil and its three metabolites had a good linear relationship in the range of 0.2–100 μg/L with a correlation coefficient R2 of more than 0.999. The recoveries at three spiked concentrations were in the range of 99.2–107.3% with the relative standard deviations less than 9.8% (intra‐day) and 8.1% (inter‐day). The limit of detection for the four target analytes was in the range of 0.02–0.06 μg/L. Finally, this method was successfully applied in the analysis of fipronil and its three metabolites in various types of environmental water samples.
Molecular pathological insights reveal a high number of unfavorable risk patients among children treated for medulloblastoma and CNS‐PNET in Oslo 2005–2017
Authors: Niehusmann Pitt , Stensvold Einar , Leske Henning , Pietsch Torsten , Goschzik Tobias , Gielen Gerrit H. , Due‐Tønnessen Bernt , Frič Radek , Nilssen Yngvar , Brandal Petter 
Published: May 2022

AbstractBackgroundAn unexplained regional difference in survival was observed in previous publications on outcome for children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor (CNS‐PNET) in Norway. We aimed now to reevaluate and perform a retrospective molecular‐based risk stratification of all embryonal brain tumors (excluding atypical teratoid rhabdoid tumors [ATRT]) in pediatric patients, who underwent surgery and treatment at Oslo University Hospital between 2005 and 2017.ProcedureSpecimens from all patients <20 years of age with initial diagnosis of medulloblastoma or CNS‐PNET were reviewed. Molecular analyses comprised NanoString gene expression, molecular inversion probe profiling, Sanger sequencing, and 850K‐methylation analysis. Whole chromosomal aberration signatures were assessed in standard‐risk non‐WNT/non‐SHH medullobastomas for molecular risk stratification.ResultsWe identified 53 non‐ATRT embryonal tumors among which 33 were medulloblastomas. Molecular genetic parameters including whole chromosomal aberration signatures allowed classification of 17 medulloblastomas as molecular high risk. These patients had a significantly worse 5‐year overall survival than the remaining 16 medulloblastoma patients (52.9% vs. 87.1% p = 0.036). Five patients in our cohort had tumors that are considered as new entities in the 2021 classification of tumors of the central nervous system. Five tumors were re‐classified as nonembryonal tumors after review.ConclusionMolecular‐based risk stratification of standard‐risk non‐WNT/non‐SHH medulloblastoma enabled superior identification of medulloblastomas with dismal prognosis. Our cohort demonstrated a significantly increased fraction of standard‐risk non‐WNT/non‐SHH medulloblastoma with molecular high‐risk profile compared to other studies, which might have contributed to previously reported unfavorable outcome data.
Use of exhausted biosorbent ash as ecofriendly filler in natural rubber
Authors: Blagojev Nevena , Šćiban Marina , Vasić Vesna , Kukić Dragana , Pavličević Jelena , Lubura Jelena , Bera Oskar 
Published: May 2022

AbstractBiosorption is a promising cost‐effective clean‐up technology for treating wastewater laden with heavy metals. However, the commercial application of biosorption technologies has been limited because a large amount of toxic waste is left behind in this process. The post‐sorbents need to be handled in a way that does not negatively affect the environment. In this research, one possibility to solve this problem was proposed and developed: incineration of used adsorbent, followed by the use of the obtained ash as a filler in rubber production. The results showed that the addition of biosorbent ash does not significantly affect the rubber mechanical and elastic properties. The ash addition affected only the beginning of the vulcanization by increasing the activation energy of the curing chemical reaction. This property can be used to prevent the premature start of vulcanization. Furthermore, it was determined whether and to what extent the ash‐filled rubber releases metal ions in contact with water. Results showed that the amount of copper leached from rubber samples was negligible compared to the copper that remained permanently built in the rubber. Therefore, this novel approach to utilizing saturated biosorbents as rubber fillers is acceptable from the environmental safety perspective. © 2022 Society of Industrial Chemistry.
Associations between mental health and care experiences among older adults with cancer
Authors: Lines Lisa M. , Barch Daniel H. , Zabala Diana , Halpern Michael T. , Jacobsen Paul B. , Mollica Michelle A. 
Published: May 2022

AbstractObjectiveWe sought to understand whether people with cancer who received mental health services reported different care experiences than those who did not.MethodsWe used Surveillance, Epidemiology, and End Results (SEER)‐Consumer Assessment of Health Providers and Systems (CAHPS) linked data to identify Medicare beneficiaries aged 66 and over diagnosed with solid tumor malignancies between 8/2006 and 12/2013. We identified mental health services using claims spanning 12 months before cancer diagnosis through up to 5 years afterward. Outcomes were care experience ratings (e.g., Overall Care) and composite measures (e.g., Doctor Communication). We estimated frequentist and Bayesian regression models adjusted for standard confounders, including sociodemographics, general and mental health status (MHS), and other characteristics. Models included interaction terms to understand whether mental healthcare changes self‐reported experiences for individuals with adverse MHS.ResultsApproximately 22% (n = 4998 individuals with cancer) had a mental health disorder claim; 17% of these reported fair/poor MHS versus only 7% of those in the cancer‐only cohort (without a mental health disorder claim). Before adjusting for mental healthcare utilization and case‐mix, worse MHS was associated with worse care experiences (p < 0.001 for all six measures). After accounting for mental health disorder‐related healthcare utilization and case mix, multivariable regression models showed no associations between MHS and worse care experiences.ConclusionsCare for mental health disorders mediates the association between MHS and perceived care experiences. The results suggest that mental health treatment may improve the self‐reported experiences of care for older adults with cancer and adverse mental health issues.
Research on Constant Speed Tension and Compression Mechanical Properties of Azide Polyether Propellant
Authors: Wu Weijing , Li Haiyang , Shen Zhibin , Cui Huiru 
Published: May 2022

AbstractAzide polyether propellant is a new type of high‐energy solid propellant with broad application prospects. In order to measure the mechanical properties of azide propellant, tensile tests of propellant under different loading conditions were carried out, and compression test pieces of azide propellant of different sizes were designed and tested, and the tensile and compressive stress‐strain curves of azide propellant were obtained. Through qualitative and quantitative analysis, the influence law of loading rate and temperature on the mechanical properties of propellant was obtained, the linear variation law of mechanical properties parameters with logarithmic strain rate was analyzed, and the mathematical relationship between propellant stiffness and strength was found. The master curve of the compressive initial modulus and maximum strength of the azide propellant was drawn. The test results can provide theoretical basis for the performance research of azide propellant and the nondestructive testing of this type of engine.
Three cytochrome P450 CYP4 family genes regulated by the CncC signaling pathway mediate phytochemical susceptibility in the red flour beetle, Tribolium castaneum
Authors: Zhang Yonglei , Yu Runnan , Tang Jing , Du Liheng , Wang Yihan , Wang Jiatao , Liu Linsu , Gao Shanshan , Li Bin 
Published: May 2022

AbstractBackgroundInsect cytochrome P450 monooxygenases (P450s) play a crucial role in phytochemical metabolism and tolerance. Three P450 genes (TcCYP4Q3, TcCYP4Q5, and TcCYP4Q7) are associated with the response of eugenol in Tribolium castaneum. However, the responding mechanisms of these P450 genes to eugenol remain unknown.ResultsHere, spatiotemporal expression profiling revealed that TcCYP4Q3 and TcCYP4Q5 were most highly expressed in late adult, while TcCYP4Q7 was predominantly expressed in late larva; and all of these three P450 genes were mainly expressed in the fat body of larvae. Furthermore, the expressions of these three P450 genes were significantly up‐regulated after exposure to eugenol, and depletion of them enhanced the susceptibility of beetles to eugenol. Interestingly, RNA interference (RNAi) against the CncC gene, a transcription factor of CncC signaling pathway associated with regulation of insect P450s in response to phytochemicals, reduced the transcripts of these three P450 genes following exposure to eugenol. Investigation of CncC signaling pathway showed that this pathway could be activated by eugenol.ConclusionAltogether, the results indicate that these three P450 genes are regulated by CncC signaling pathway to participate in the susceptibility of Tribolium castaneum to phytochemicals. These findings will aid implications for the development of novel therapeutics to control pest. © 2022 Society of Chemical Industry.
Paeoniflorin ameliorates lipopolysaccharide‐induced acute liver injury by inhibiting oxidative stress and inflammation via SIRT1/FOXO1a/SOD2 signaling in rats
Authors: Li Lin , Wang Hui , Zhao Shuping , Zhao Yuan , Chen Yongping , Zhang Jiuyan , Wang Chuqiao , Sun Ning , Fan Honggang 
Published: May 2022

AbstractAcute liver injury (ALI) is a poor prognosis and high mortality complication of sepsis. Paeoniflorin (PF) has remarkable anti‐inflammatory effects in different disease models. Here, we explored the protective effect and underlying molecular mechanisms of PF against lipopolysaccharide (LPS)‐induced ALI. Sprague‐Dawley rats received intraperitoneal (i.p.) injection of PF for 7 days, 1 h after the last administration, and rats were injected i.p. 10 mg/kg LPS. PF improved liver structure and function, reduced hepatic reactive oxygen species (ROS) and methane dicarboxylic aldehyde (MDA) levels, and increased superoxide dismutase (SOD) activity. Western blot analysis suggested that PF significantly inhibited expression of inflammatory cytokines (TNF‐α, IL‐1β, and IL‐18) and inhibited activation of the NLRP3 inflammasome. PF or mitochondrial ROS scavenger (mito‐TEMPO) significantly improved liver mitochondrial function by scavenging mitochondrial ROS (mROS), restoring mitochondrial membrane potential loss and increasing level of ATP and enzyme activity of complex I and III. In addition, PF increased expression of sirtuin‐1 (SIRT1), forkhead box O1 (FOXO1a) and manganese superoxide dismutase (SOD2), and increased FOXO1a nuclear retention. However, the inhibitor of SIRT1 (EX527) abolished the protective effect of PF. Taken together, PF promotes mROS clearance to inhibit mitochondrial damage and activation of the NLRP3 inflammasome via SIRT1/FOXO1a/SOD2 signaling.
Nutmeg (Myristica fragrans Houtt.) essential oil: A review on its composition, biological, and pharmacological activities
Authors: Ashokkumar Kaliyaperumal , Simal‐Gandara Jesus , Murugan Muthusamy , Dhanya Mannananil Krishnankutty , Pandian Arjun 
Published: May 2022

AbstractMyristica fragrans (Houtt.) is an evergreen tree native to the Maluku Islands, Indonesia. M. fragrans kernel is extensively used in Indian traditional medicines to treat various diseases. Several studies attempt to compile and interpret the pharmacological potential of Myristica fragrans (Houtt.) aqueous and various chemical extracts. Thus, the pharmacological potential of nutmeg essential oil has not been reviewed phytochemically and pharmacologically. Therefore, the present study aimed to share appropriate literature evidence regarding the plant essential oil chemical composition and therapeutic potential of Myristica fragrans essential oil (MFEO). MFEO of leaf, mace, kernel, and seed were used worldwide as potential Ayurvedic medicine and fragrance. MFEO extracted by various methods and oil yield was 0.7–3.2, 8.1–10.3, 0.3–12.5, and 6.2–7.6% in leaf, mace, seed, and kernel. The primary chemical constituents of MFEO were sabinene, eugenol, myristicin, caryophyllene, β‐myrcene, and α‐pinene. Clinical and experimental investigations have confirmed the antioxidant, antimicrobial, antiinflammatory, anticancer, antimalarial, anticonvulsant, hepatoprotective, antiparasitic, insecticidal, and nematocidal activities of MFEO. It is the first attempt to compile oil yield, composition, and the biological activities of MFEO. In future, several scientific investigations are required to understand the mechanism of action of MFEO and their bioactive constituents.
Extra predictability from a seamless approach for Asian summer monsoon precipitation from days to weeks
Authors: Li Xiaojing , Tang Youmin , Song Xunshu 
Published: May 2022

AbstractMultiple‐scale atmospheric or oceanic prediction has been a challenging issue due to the different dynamical and thermodynamic processes involved and the uncertainty inherent in highly nonlinear and stochastic forcing, such as the prediction of Asian summer monsoon (ASM) precipitation. Seamless prediction was proposed to address this issue. The idea behind this approach is that temporal averaging reduces the spread of the prediction ensemble but retains the approximate first moment, which effectively increases the signal‐to‐noise ratio of the prediction. In this study, the superiority of the seamless prediction was assessed for the ASM precipitation at time‐scales from days to weeks. The hindcasts from the European Centre for Medium‐Range Weather Forecasts in the Subseasonal to Seasonal ensemble dataset were used for the detailed assessment. Results show significant advantages of the seamless approach in evaluating the ASM precipitation prediction on time‐scales ranging from 2 days to 2 weeks. Furthermore, the source of the average window predictability was analysed for two lead times with significantly superior prediction accuracy: lead times of 4d4d and 3w3w. For 4d4d, the Madden–Julian Oscillation is dominant, while the role of the El Niño–Southern Oscillation phase becomes substantial for 3w3w. These results offer a detailed analysis for the prediction of ASM precipitation within a framework of seamless prediction, benefiting further interpretation of seamless prediction of ASM precipitation.
Development of disaster‐responding special‐purpose machinery: Results of experiments
Authors: Kim Jin Tak , Park Sangshin , Han SangChul , Kim Jinhyeon , Kim Hyogon , Choi Young‐Ho , Seo Jaehong , Chon Sanguk , Kim Jungyeong , Cho Jungsan 
Published: May 2022

AbstractThe frequent occurrence of disasters has prompted the development of efficient disaster‐responding equipment. This study deals with the design of special‐purpose machinery and its performance assessment. We defined scenarios through the environmental analysis of disaster situations and expert consulting. We also formulated a set of design specifications by analyzing the objectives of the tasks that must be performed at disaster sites, based on simulated scenarios and existing disaster response machinery. The disaster‐responding special‐purpose machinery was designed to perform various tasks and display rapid movement in disaster situations. Moreover, this paper presents the control structure configured to operate the developed machinery. The performance of the special‐purpose machinery was assessed through different scenario tests.