bluuebunny/crossref_metadata_2025_split huggingface dataset:
One-loop matching for quark dipole operators in a gradient-flow scheme
Authors: Mereghetti Emanuele , Monahan Christopher J. , Rizik Matthew D. , Shindler Andrea , Stoffer Peter 
Published: April 2022

Abstract
The quark chromoelectric dipole (qCEDM) operator is a CP-violating operator describing, at hadronic energies, beyond-the-standard-model contributions to the electric dipole moment of particles with nonzero spin. In this paper we define renormalized dipole operators in a regularization-independent scheme using the gradient flow, and we perform the matching at one loop in perturbation theory to renormalized operators of the same and lower dimension in the more familiar MS scheme. We also determine the matching coefficients for the quark chromo-magnetic dipole operator (qCMDM), which contributes for example to matrix elements relevant to CP-violating and CP-conserving kaon decays. The calculation provides a basis for future lattice QCD computations of hadronic matrix elements of the qCEDM and qCMDM operators.
$$ \mathrm{T}\overline{\mathrm{T}} $$ + Λ2 deformed CFT on the stretched dS3 horizon
Authors: Shyam Vasudev 
Published: April 2022

Abstract
The $$ T\overline{T} $$
T

T
¯

+ Λ2 deformation of a Holographic CFT on a cylinder (or torus in Euclidean signature) inhabits the stretched cosmological horizon in dS3 when the deformation parameter is tuned to a particular value. I will describe how this insight allows us to compute the entropy of the stretched cosmic horizon including the logarithmic correction.
Homogeneous Yang-Baxter deformations as undeformed yet twisted models
Authors: Borsato Riccardo , Driezen Sibylle , Miramontes J. Luis 
Published: April 2022

Abstract
The homogeneous Yang-Baxter deformation is part of a larger web of integrable deformations and dualities that recently have been studied with motivations in integrable σ-models, solution-generating techniques in supergravity and Double Field Theory, and possible generalisations of the AdS/CFT correspondence. The σ-models obtained by the homogeneous Yang-Baxter deformation with periodic boundary conditions on the worldsheet are on-shell equivalent to undeformed models, yet with twisted boundary conditions. While this has been known for some time, the expression provided so far for the twist features non-localities (in terms of the degrees of freedom of the deformed model) that prevent practical calculations, and in particular the construction of the classical spectral curve. We solve this problem by rewriting the equation defining the twist in terms of the degrees of freedom of the undeformed yet twisted model, and we show that we are able to solve it in full generality. Remarkably, this solution is a local expression. We discuss the consequences of the twist at the level of the monodromy matrix and of the classical spectral curve, analysing in particular the concrete examples of abelian, almost abelian and Jordanian deformations of the Yang-Baxter class.
On the stability of string theory vacua
Authors: Giri Suvendu , Martucci Luca , Tomasiello Alessandro 
Published: April 2022

Abstract
Vacuum compactifications may suffer from instabilities under small perturbations or tunnel effects; both are difficult to analyze. In this paper we consider the issue from a higher-dimensional perspective. We first look at how stability works for supersymmetric vacua, where it is widely expected to hold. We first show that the nucleation of brane bubbles in type II AdS compactifications is forbidden in the probe approximation by a simple argument involving pure spinors and calibrations. We then adapt familiar positive-energy theorems directly to M-theory and type II supergravity, rather than to their effective lower-dimensional reductions, also showing how to consistently include localized sources. We finally initiate an analysis of how these arguments might be extended to non-supersymmetric vacua. In M-theory, at the lower-derivative level, we find that the most natural modifications fail to stabilize the skew-whiffed and Englert vacua.
On massive higher spins in d = 3
Authors: Khabarov M. V. , Zinoviev Y. M. 
Published: April 2022

Abstract
In this paper we consider a frame-like gauge invariant description of massive higher spin bosons and fermions in d = 3 and provide for the first time a proof that such formulation does describe just one massive physical degree of freedom with the appropriate helicity. For this purpose we completely fix all the gauge symmetries and show that all other auxiliary components vanish on-shell, while the only remaining highest component satisfies the correct equations. As a bonus, we show that the Lagrangians for the so-called self-dual massive spin-3 and spin-4 fields proposed by Aragone and Khoudeir (as well as their generalization to arbitrary integer and half-integer spins) can be obtained from the gauge invariant ones by the appropriate gauge fixing.
Precision tests of quantum mechanics and $$ \mathcal{CPT} $$ symmetry with entangled neutral kaons at KLOE
Authors:   The KLOE-2 collaboration, Babusci D. , Berlowski M. , Bloise C. , Bossi F. , Branchini P. , Budano A. , Cao B. , Ceradini F. , Ciambrone P. , Curciarello F. , Czerwiński E. , D’Agostini G. , D’Amico R. , Danè E. , De Leo V. , De Lucia E. , De Santis A. , De Simone P. , Di Cicco A. , Di Domenico A. , Diociaiuti E. , Domenici D. , D’Uffizi A. , Fantini A. , Fantini G. , Fermani P. , Fiore S. , Gajos A. , Gauzzi P. , Giovannella S. , Graziani E. , Ivanov V. L. , Johansson T. , Kang X. , Kisielewska-Kamińska D. , Kozyrev E. A. , Krzemien W. , Kupsc A. , Lukin P. A. , Mandaglio G. , Martini M. , Messi R. , Miscetti S. , Moricciani D. , Moskal P. , Passeri A. , Patera V. , Perez del Rio E. , Santangelo P. , Schioppa M. , Selce A. , Silarski M. , Sirghi F. , Solodov E. P. , Tortora L. , Venanzoni G. , Wiślicki W. , Wolke M. 
Published: April 2022

Abstract
The quantum interference between the decays of entangled neutral kaons is studied in the process ϕ → KSKL → π+π−π+π−, which exhibits the characteristic Einstein-Podolsky-Rosen correlations that prevent both kaons to decay into π+π− at the same time. This constitutes a very powerful tool for testing at the utmost precision the quantum coherence of the entangled kaon pair state, and to search for tiny decoherence and $$ \mathcal{CPT} $$
CPT
violation effects, which may be justified in a quantum gravity framework.The analysed data sample was collected with the KLOE detector at DAΦNE, the Frascati ϕ-factory, and corresponds to an integrated luminosity of about 1.7 fb−1, i.e. to about 1.7 × 109ϕ → KSKL decays produced. From the fit of the observed ∆t distribution, being ∆t the difference of the kaon decay times, the decoherence and $$ \mathcal{CPT} $$
CPT
violation parameters of various phenomenological models are measured with a largely improved accuracy with respect to previous analyses.The results are consistent with no deviation from quantum mechanics and $$ \mathcal{CPT} $$
CPT
symmetry, while for some parameters the precision reaches the interesting level at which — in the most optimistic scenarios — quantum gravity effects might show up. They provide the most stringent limits up to date on the considered models.
Novel integrated workflow allows production and in-depth quality assessment of multifactorial reprogrammed skeletal muscle cells from human stem cells
Authors: Faustino Dinis , Brinkmeier Heinrich , Logotheti Stella , Jonitz-Heincke Anika , Yilmaz Hande , Takan Isil , Peters Kirsten , Bader Rainer , Lang Hermann , Pavlopoulou Athanasia , Pützer Brigitte M. , Spitschak Alf 
Published: April 2022

AbstractSkeletal muscle tissue engineering aims at generating biological substitutes that restore, maintain or improve normal muscle function; however, the quality of cells produced by current protocols remains insufficient. Here, we developed a multifactor-based protocol that combines adenovector (AdV)-mediated MYOD expression, small molecule inhibitor and growth factor treatment, and electrical pulse stimulation (EPS) to efficiently reprogram different types of human-derived multipotent stem cells into physiologically functional skeletal muscle cells (SMCs). The protocol was complemented through a novel in silico workflow that allows for in-depth estimation and potentially optimization of the quality of generated muscle tissue, based on the transcriptomes of transdifferentiated cells. We additionally patch-clamped phenotypic SMCs to associate their bioelectrical characteristics with their transcriptome reprogramming. Overall, we set up a comprehensive and dynamic approach at the nexus of viral vector-based technology, bioinformatics, and electrophysiology that facilitates production of high-quality skeletal muscle cells and can guide iterative cycles to improve myo-differentiation protocols.
S-acylation-dependent membrane microdomain localization of the regulatory Kvβ2.1 subunit
Authors: Roig Sara R. , Cassinelli Silvia , Navarro-Pérez María , Pérez-Verdaguer Mireia , Estadella Irene , Capera Jesusa , Felipe Antonio 
Published: April 2022

AbstractThe voltage-dependent potassium (Kv) channel Kvβ family was the first identified group of modulators of Kv channels. Kvβ regulation of the α-subunits, in addition to their aldoketoreductase activity, has been under extensive study. However, scarce information about their specific α-subunit-independent biology is available. The expression of Kvβs is ubiquitous and, similar to Kv channels, is tightly regulated in leukocytes. Although Kvβ subunits exhibit cytosolic distribution, spatial localization, in close contact with plasma membrane Kv channels, is crucial for a proper immune response. Therefore, Kvβ2.1 is located near cell surface Kv1.3 channels within the immunological synapse during lymphocyte activation. The objective of this study was to analyze the structural elements that participate in the cellular distribution of Kvβs. It was demonstrated that Kvβ peptides, in addition to the cytoplasmic pattern, targeted the cell surface in the absence of Kv channels. Furthermore, Kvβ2.1, but not Kvβ1.1, targeted lipid raft microdomains in an S-acylation-dependent manner, which was concomitant with peptide localization within the immunological synapse. A pair of C-terminal cysteines (C301/C311) was mostly responsible for the specific palmitoylation of Kvβ2.1. Several insults altered Kvβ2.1 membrane localization. Therefore, growth factor-dependent proliferation enhanced surface targeting, whereas PKC activation impaired lipid raft expression. However, PSD95 stabilized Kvβ2.1 in these domains. This data shed light on the molecular mechanism by which Kvβ2.1 clusters into immunological synapses during leukocyte activation.
Joints of Varieties
Authors: Tidor Jonathan , Yu Hung-Hsun Hans , Zhao Yufei 
Published: April 2022

AbstractWe generalize the Guth–Katz joints theorem from lines to varieties. A special case says that N planes (2-flats) in 6 dimensions (over any field) have $$O(N^{3/2})$$

O
(

N

3
/
2

)

joints, where a joint is a point contained in a triple of these planes not all lying in some hyperplane. More generally, we prove the same bound when the set of N planes is replaced by a set of 2-dimensional algebraic varieties of total degree N, and a joint is a point that is regular for three varieties whose tangent planes at that point are not all contained in some hyperplane. Our most general result gives upper bounds, tight up to constant factors, for joints with multiplicities for several sets of varieties of arbitrary dimensions (known as Carbery’s conjecture). Our main innovation is a new way to extend the polynomial method to higher dimensional objects, relating the degree of a polynomial and its orders of vanishing on a given set of points on a variety.
Dismantling AI capitalism: the commons as an alternative to the power concentration of Big Tech
Authors: Verdegem Pieter 
Published: April 2022

AbstractThis article discusses the political economy of AI capitalism. It considers AI as a General Purpose Technology (GPT) and argues we need to investigate the power concentration of Big Tech. AI capitalism is characterised by the commodification of data, data extraction and a concentration in hiring of AI talent and compute capacity. This is behind Big Tech’s unstoppable drive for growth, which leads to monopolisation and enclosure under the winner takes all principle. If we consider AI as a GPT—technologies that alter society’s economic and social structures—we need to come up with alternatives in terms of ownership and governance. The commons is proposed as an alternative for thinking about how to organise AI development and how to distribute the value that can be derived from it. Using the commons framework is also a way of giving society a more prominent role in the debate about what we expect from AI and how we should approach it.
Should criminal law protect love relation with robots?
Authors: Mamak Kamil 
Published: April 2022

AbstractWhether or not we call a love-like relationship with robots true love, some people may feel and claim that, for them, it is a sufficient substitute for love relationship. The love relationship between humans has a special place in our social life. On the grounds of both morality and law, our significant other can expect special treatment. It is understandable that, precisely because of this kind of relationship, we save our significant other instead of others or will not testify against her/him. How as a society should we treat love-like relationships humans with robots? Based on the assumption that robots do not have an inner life and are not moral patients, I defend the thesis that this kind of relationship should be protected by criminal law.
Surgeons, Hernia Surgery and Informed Consent in the Seventeenth Century Ottoman Istanbul
Authors: Degerli Mahmut Said 
Published: April 2022

AbstractBackgroundIn the seventeenth century Ottoman Istanbul, especially Greek surgeons specialized in hernia surgery. Both Muslim and non‐Muslim patients had signed contracts with surgeons in sharia courts before undergoing a surgery. In this study, we analyze these documents, which serve as informed consent in the Ottoman period, in detail.MethodsWe used Istanbul Sharia Court Registers (Istanbul Sicils) as the primary information source. We scanned a total of twenty nine registers dating back to the seventeenth century. In six of these registers, we determined a total of twenty one informed consents (known as rıza senedi in Turkish literature) regarding hernia surgery and surgeons. Based on these data, we examined the surgeons and hernia surgeries, the fees received by surgeons, and the informed consent documents of the seventeenth‐century Istanbul.ResultsIn the scanned informed consents, we identified five male surgeons and twenty one patients. While four of the surgeons were Greek, one of them was Muslim. The contracts show that the patients were informed about possible complications before operations, and their permissions were obtained accordingly. The contracts also clearly state that a blood‐money from the surgeons would not be requested if a patient dies during or after an operation. The cost of operations ranged between 500 and 2100 aḳče.ConclusionsThe patient‐physician relationship in Ottomans was seen as a business relationship. Medical processes were recorded in courts before treatment fees were paid. These court records had been a practice that protected the patients and the physicians in terms of criminal liability.
Immune reconstitution and survival of patients with parvovirus B19 related pure red cell aplasia after haplo-PBSCT
Authors: Zhou Xiao , Jiang Peiyao , Gao Lu , Yang Jun , Cai Yu , Tong Yin , Qiu Huiying , Huang Chongmei , Zhou Kun , Xu Xiaowei , Niu Jiahua , Xia Xinxin , Zhang Ying , Shen Chang , Wei Yu , Shao Jie , Song Xianmin , Wan Liping 
Published: April 2022

AbstractParvovirus B19 (PvB19) infection and PvB19 related pure red cell aplasia (PRCA) in recipients with allogeneic hematopoietic stem cell transplantation have been reported sporadically. However, clinical studies with large sample sizes are lacking, especially in patients undergoing HLA-haploidentical peripheral blood stem cell transplantation (haplo-PBSCT). In addition, clinical features, immune reconstitution, and outcomes of these patients are not clear. We conducted a retrospective analysis of 164 patients who received haplo-PBSCT with low-dose anti-thymocyte globulin (ATG) plus low-dose posttransplant cyclophosphamide (PTCy)-based regimen as graft-versus-host disease (GVHD) prophylaxis. We analyzed the incidence of PvB19 related PRCA and compared the clinical characteristics, immune reconstitution, incidence of GVHD, relapse rate, and survival between patients with and without PvB19 related PRCA. A total of 14 (8.5%) recipients developed PvB19 related PRCA after a median of 5.3 months after haplo-PBSCT. These patients with PvB19 related PRCA had slower immune reconstitution, but similar incidences of GVHD, relapse rate, and overall survival compared with recipients without PvB19 related PRCA. PvB19 related PRCA indicated relative delayed and poor immune reconstitution of the recipients early after haplo-PBSCT. PvB19 related PRCA had no effects on GVHD, relapse, and survival.
Influence of Boron and Drought Simulation on Germinability and Hardseededness of Black Medick Seeds (Medicago lupulina L.)
Authors: Kintl Antonín , Huňady Igor , Ondrisková Vladěna , Hammerschmiedt Tereza , Brtnický Martin , Vejražka Karel , Kubíková Zuzana , Elbl Jakub 
Published: April 2022

AbstractThis study deals with the determination of germinability of black medick (Medicago lupulina L.) seeds in conditions of different drought intensity induced by different concentrations of PEG 8000 solutions (0.2; 0.4; 0.6 mol). Four batches of seed were tested (Ekola 2–5). At the same time, the influence of boron, some other elements (N, P, K, Ca, Mg, Zn, Cu, Mn) and compounds (starch, lipids and sugars) contents in black medick seeds on their germinability (percentages of germinated, dead and hard seeds) was evaluated. The effect of drought was manifested by germination which was reduced max. by 8% as compared with the control variant and was only partially significant. Statistically significant (P < 0.01) negative correlations (R = − 0.64) were recorded between germinability and the boron content in the seeds, and positive correlations were found between the percentages of hard seeds and the boron content in the seeds. The results show that the higher content of boron in the seeds of black medick increases the proportion of hard seeds at the expense of the germinated seeds percentages.
Intensive exercise therapy for restenosis after superficial femoral artery stenting: the REASON randomized clinical trial
Authors: Kato Tamon , Miura Takashi , Yamamoto Shuhei , Miyashita Yusuke , Hashizume Naoto , Shoin Kyoko , Sasaki Shinya , Kanzaki Yusuke , Yui Hisanori , Maruyama Shusaku , Nagae Ayumu , Sakai Takahiro , Saigusa Tatsuya , Ebisawa Soichiro , Okada Ayako , Motoki Hirohiko , Ikeda Uichi , Kuwahara Koichiro ,   The REASON Investigators, Kato Tamon , Miura Takashi , Yamamoto Shuhei , Miyashita Yusuke , Hashizume Naoto , Shoin Kyoko , Sasaki Shinya , Kanzaki Yusuke , Ikeda Uichi 
Published: April 2022

AbstractEndovascular treatment (EVT) is the main treatment for peripheral artery disease (PAD). Despite advances in device development, the restenosis rate remains high in patients with femoropopliteal lesions (FP). This study aimed to evaluate the effectiveness of exercise training in reducing the 1-year in-stent restenosis rate of bare metal nitinol stents for FPs. This prospective, randomized, open-label, multicenter study was conducted from January 2017 to March 2019. We randomized 44 patients who had claudication with de novo stenosis or occlusion of the FP into an intensive exercise group (n = 22) and non-intensive exercise group (n = 22). Non-intensive exercise was defined as walking for less than 30 min per session, fewer than three times a week. We assessed exercise tolerance using an activity meter at 1, 3, 6, and 12 months, and physiotherapists ensured maintenance of exercise quality every month. The primary endpoint was instant restenosis defined as a peak systolic velocity ratio > 2.5 on duplex ultrasound imaging. Kaplan–Meier analysis was used to evaluate the data. There were no significant differences in background characteristics between the groups. Six patients dropped out of the study within 1 year. In terms of the primary endpoint, intensive exercise significantly improved the patency rate of bare nitinol stents at 12 months. The 1-year freedom from in-stent restenosis rates were 81.3% in the intensive exercise group and 47.6% in the non-intensive exercise group (p = 0.043). No cases of stent fracture were observed in the intensive exercise group. Intensive exercise is safe and reduces in-stent restenosis in FP lesions after endovascular therapy for PAD. Clinical trial registration: University Hospital Medical Information Network Clinical Trials Registry (No. UMIN 000025259).
Second fertility-sparing surgery and fertility-outcomes in patients with recurrent borderline ovarian tumors
Authors: Wang Lifei , Zhong Qian , Tang Qin , Wang Hongjing 
Published: April 2022

Abstract
Background
At the time of recurrence, many borderline ovarian tumor (BOT) patients are still young with fertility needs. The purpose of this study is to evaluate the reproductive outcomes and recurrence rate of second fertility-sparing surgery (FSS) in women with recurrent BOTs.

Methods
Seventy-eight women of childbearing age diagnosed with recurrent BOTs from November 2009 to 2020 whose primary treatment was FSS were included.

Results
The FIGO stage I disease accounted for 46.2% and serous BOT accounted for 87.2% in the study group. Forty-seven patients underwent second FSS, and the remaining 31 underwent radical surgery (RS). Seventeen patients relapsed again after second surgery, but no malignant transformation and tumor-associated deaths were reported. Compared to FIGO stage I, the FIGO stage III tumors were more likely to relapse, but there was no statistical difference in pregnancy rate among patients with different stages. In the second FSS group, recurrence rate was higher in patients who underwent oophorocystectomy compared to patients with unilateral salpingo-oophorectomy (USO), but the pregnancy rate was similar. There was no significant difference in postoperative recurrence risk between USO and RS. The recurrence rate was not associated with operative route (laparoscopy or laparotomy), or lymphadenectomy, or postoperative chemotherapy. Among the 32 patients who tried to conceive, the pregnancy rate was 46.9% and live birth rate was 81.3%.

Conclusion
Unilateral salpingo-oophorectomy is a safe procedure for FIGO stage I recurrent BOT patients with fertility needs, and can achieve a high postoperative pregnancy rate and live birth rate.