bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Predictive Value Of The Left Atrial Kinetic Energy For Atrial Fibrillation Recurrence
Authors: ÇAMCI Sencer , ARI Hasan , ARI Selma , KARAKUS Alper , MELEK Mehmet , BOZAT Tahsin 
Published: March 2022

Abstract
Introduction: Determining which patients will experience recurrence of atrial fibrillation (AF) is crucial for treatment modification. Aim: This study aimed to investigate the value of left atrial kinetic energy (LAKE) in atrial fibrillation recurrenceMethods: A total of 120 consecutive patients who achieved sinus rhythm with electrical direct current cardioversion and met the inclusion criteria were included in the study. TTE and LAKE values were calculated on the first day after cardioversion. Rhythm control was performed with 12-lead electrocardiography in the first month follow-up. LAKE values calculated using TTE was compared between two groups of patients – those who remained in sinus rhythm and those who developed AF.Results: While 81 (67.5%) patients were in sinus rhythm at one month, AF recurrence was detected in 39 (32.5%) patients. In the AF group, while AF duration, cardioversion energy, number of diabetic patients, left atrial (LA) diameter, LA pre A volume, LA minimum volume, and pulmonary artery pressure values were found to be significantly higher than those in the SR group, mitral A velocity and LAKE values were significantly lower. In multivariate regression analysis, AF duration (OR: 1.55 [CI: 95%; 1.23–1.95]; p < 0.001), LA diameter (OR: 1.36 [CI: 95%; 1.11–1.66]; p = 0.003) and LAKE (OR: 0.96 [CI: 95%: 0.94–0.99]; p = 0.008) were determined to be independent predictors of AF recurrence at one month.Conclusions: LA diameter, AF duration, and LAKE were found to be significant predictors of AF recurrence after cardioversion. NCT05231967
NF-Κb, A Potential Therapeutic Target, In Cardiovascular Diseases
Authors: Cheng Weijia , Cui can , Liu Gang , Ye Chenji , Shao Fang , Mehta Jay L. , Wang Xianwei 
Published: March 2022

Abstract
Cardiovascular diseases (CVDs) are the leading cause of death globally. Atherosclerosis is the basis of major CVDs - myocardial ischemia, heart failure and stroke. Among numerous functional molecules, the transcription factor nuclear factor κB (NF-κB) has been linked to downstream target genes involved in atherosclerosis. The activation of NF-κB family and its downstream target genes in response to environmental and cellular stress, hypoxia and ischemia initiate different pathological events such as innate and adaptive immunity, and cell survival, differentiation and proliferation. Thus, NF-κB is a potential therapeutic target in the treatment of atherosclerosis and related CVDs. Several biologics and small molecules as well as peptide/proteins have been shown to regulate NF-κB dependent signaling pathways. In this review, we will focus on the function of NF-κB in CVDs and the role of NF-κB inhibitors in the treatment of CVDs.
Mean Estimation of Scrambled Responses using Systematic Sampling
Authors: Qureshi Muhammad Nouman , Balqees Sajida , Hanif Muhammad 
Published: March 2022

Abstract
Asking a question directly on which respondent feel hesitate to reply is a very crucial for almost all the researchers. To overcome this situation Warner (1965) dealt with sensitive issues and proposed Randomized Response Technique ( RRT ). In this paper, we have suggested the classical estimators and the generalized estimator for the estimation of scrambled responses using auxiliary information in systematic random sampling. The mathematical expressions for approximate bias and mean square error of the mentioned estimators are obtained up to the first-order approximation. The algebraic conditions are also obtained for which the generalized estimator may perform better than the classical estimators. An extensive numerical study is conducted to assess the performance of the mentioned estimators using real and artificial populations at different level of correlations.
Relations Between Four Assessment Scales and Improved Medication Adherence in Alzheimer’s Disease Population
Authors: HE Minchao , WANG Yuhong 
Published: March 2022

Abstract
Background and ObjectivesThis study aimed to investigate whether Alzheimer's disease (AD) assessment scales, which are widely being used in clinic, had relation with the improved medication adherence of AD patients. MethodsIn this prospective study, fifty-eight participants were recruited and thirty-one finally finished the procedures. Four neuropsychological scales (Alzheimer’s diseases Assessment Scale-Cognitive Subscale, Activity of Daily Living Scale, Neuropsychiatric Inventory, and The Clinician Interview-based Impression of Change, plus carer interview) were implemented and medication adherence rate were improved by multiple subjective methods (involving healthcare providers and caregivers), from June 2014 to June 2018. Statistical methods included bivariate and partial correlations controlled by the clinical factors of multiple patients. Correlation analysis were carried out for each item in the cognitive part of the Alzheimer's Disease Rating scale and medication adherence. ResultsThe median adherence rate was 98.04%. No correlation between the four scales and the medication adherence of patients with AD was identified (P > 0.05). Partial correlation analysis also failed to reveal the correlation after excluding medication adherence–related factors (P > 0.05). But in Alzheimer's diseases Assessment Scale-Cognitive Subscale, scores of Commands and Constructional Praxis had a weak correlation with medication adherence (P = 0.015 and P = 0.033; correlation coefficients were 0.201 and 0.177, respectively). ConclusionsExisting AD neuropsychological scales showed no relation with medication adherence rate elevated by multiple methods in AD patients, while performance, language, and visuospatial ability might be related to medication adherence in these population.Trial registrationClinicalTrials.gov Identifier: NCT02293915
Comparison of Various Smoothness Metrics for Upper Limb Movements in Healthy Subjects
Authors: BAYLE Nicolas , LEMPEREUR Mathieu , HUTIN Emilie , MOTAVASSELI Damien , REMY-NERIS Olivier , GRACIES Jean-Michel , CORNEC Gwenaël 
Published: March 2022

Abstract
Background Metrics for movement smoothness include the number of zero-crossings on acceleration profiles (N0C), the Log Dimensionless Jerk (LDLJ), the Normalized Averaged Rectified Jerk (NARJ) and the Spectral Arc Length (SPARC). Sensitivity to handedness and movement type of these four metrics were compared and correlations with other kinematic parameters were explored in healthy subjects.MethodsThirty-two healthy participants (age 63±16 y) underwent 3D upper limb motion analysis during two sets of pointing movements on each side. Participants were seated, palm of the hand facing down on the table before movement onset; they performed forward-pointing movements (FPM) at self-selected speed to a target located ahead at shoulder height and at 90% arm length, and backward pointing movements (BPM), back to the initial position, with and without a three-second pause between FPM and BPM. Kinematics (including trajectory and velocity) were collected and N0C, SPARC, LDLJ and NARJ were computed.ResultsLDLJ, NARJ and N0C found backward movements to be smoother while SPARC found the opposite. No smoothness metric indicated differences across sides. Inter- and intra-subject coefficients of variation were lowest for SPARC. LDLJ, NARJ and N0C were correlated with each other and with movement time, unlike SPARC. ConclusionsThere are major differences between smoothness metrics measured in the temporal domain (N0C, LDLJ, NARJ), which depend on movement time, and that measured in the frequency domain, the SPARC, which gave results opposite to the other metrics when comparing backward and forward movements.Trial Registration Registration number, ID-RCB: NCT01383512, registered on 28 June 2011, updated on 11 October 2017.Approved by the Institutional Review Board of Brest University Hospital under the number 653.
Computational Study on the Clamping Mechanism in Injection Molding Machine
Authors: Le Van-Duong , Hoang Van-Thanh , Bang Tao Quang , Benabou Lahouari , Tran Ngoc-Hai , Luu Duc-Binh , Park Jang Min 
Published: March 2022

Abstract
The clamping mechanism plays an important role in obtaining high-quality products of the injection molding process. The clamping mechanism of five-point double-toggle has been widely used for the high-speed plastics injection molding machine. The purpose of this paper is to optimize the five-point double-toggle clamping mechanism through multi-body dynamics analysis. This work also provides guidelines and a clear understanding for designing the clamping system in an injection molding machine with various clamping forces. The theoretical calculation has been handled first and then the computational model has been verified in this study. In addition, the effects of clamping forces on the main dimensions, including movable-fixed plate thickness, tie-bar diameter and average link cross-section have been investigated theoretically and numerically. The results show that the optimal design allows reaching a high force amplified ratio and that the obtained mechanism has good kinematic performance and works steadily with lower energy consumption and lower cost than the preliminary design. Moreover, the relationships between the parameters such as the critical angles of the double-toggle clamping mechanism, the ratio of force amplification and the stroke of movable mold have been found in this work. The optimized parameters will yield useful knowledge to design and manufacture the clamping mechanism of the micro injection molding machine in practice.
Canalized gene expression during development mediates caste differentiation in ants
Authors: Qiu Bitao , Dai Xueqin , Li Panyi , Larsen Rasmus , Li Ruyan , Price Alivia , Ding Guo , Texada Michael , Zhang Xiafang , Zuo Dashuang , Gao Qionghua , Jiang Wei , Wen Tinggang , Pontieri Luigi , Guo Chunxue , Rewitz Kim , Li Qiye , Liu Weiwei , Boomsma Jacobus , Zhang Guojie 
Published: March 2022

Abstract
Ant colonies are higher-level organisms consisting of specialized reproductive and non-reproductive individuals that differentiate early in development, similar to germ-soma segregation in bilateral Metazoa. Analogous to diverging cell lines, developmental differentiation of individual ants has often been considered in epigenetic terms, but the sets of genes that determine caste phenotypes throughout larval and pupal development remain unknown. Here we reconstruct the individual developmental trajectories of two ant species after obtaining > 1400 whole-genome transcriptomes. Using a novel backward prediction algorithm, we show that caste phenotypes can be accurately predicted by genome-wide transcriptome profiling. We find that caste differentiation is increasingly canalized from early development onwards, particularly in germline individuals (gynes/queens), and that the juvenile hormone signalling pathway regulates this process with feedback from diverging larval body mass. We quantified gene-specific canalization levels and found that canalized genes with gyne/queen-biased expression were enriched for ovary and wing functions while canalized genes with worker-biased expression were enriched in brain and behavioural functions. Suppression in gyne larvae of Freja, a highly canalized gyne-biased ovary gene, disturbed pupal development by inducing non-adaptive intermediate phenotypes between gynes and workers. Our results indicate that the life cycle ontogeny of colonial superorganisms is maintained by strong purifying selection.
Metastasis patterns and prognosis in young breast cancer patients: a SEER database analysis
Authors: zhang weifang , Liu Jinzhao , Zhang Xiangmei , Yang Chao , Cao Miao , Zhang Shuo , Liu Yunjiang 
Published: March 2022

Abstract
Background
There are few studies on young patients with metastatic breast cancer. This study aims to explore the metastasis pattern and prognosis of young patients with metastatic breast cancer.
Methods
6336 metastatic breast cancer patients diagnosed in the Surveillance, Epidemiology and End results database from 2010 to 2015 were selected. They were divided into three age groups: the younger group (≤ 40 years old), middle-aged group (41–69 years old) and older group (≥ 70 years old). χ2 test was used to compare clinicopathological characteristics. Survival differences were compared by Kaplan–Meier analysis. Cox regression models were used to determine the prognostic factors affecting survival.
Results
Finally, 494 patients (7.8%) ≤ 40 years old, 3957 patients (62.5%) 41–69 years old, and 1885 patients (29.7%) ≥ 70 years old were included. In younger group, the proportion of liver metastasis was significantly higher than that in middle-aged group and older group; the proportion of lung metastasis was significantly lower than that of the older group, but there was no significant difference with the middle-aged group. Kaplan-meier analysis showed that the younger group had the best prognosis and the older group had the worst. Youth is an independent protective factor for survival.In the young group, liver metastasis had the best prognosis among all metastatic sites, and HR-/HER2 + had the best prognosis among all molecular subtypes.
Conclusions
The disease in young metastatic breast cancer patients is more aggressive but has a better prognosis, especially in liver metastases and the HR-/HER2 + subtypes.
Engineering of macrophage targeted Punicalagin nanoparticles by computational modeling to alleviate methotrexate induced neutropenia
Authors: Raj Ritu 
Published: March 2022

Abstract
Punicalagin is the most bioactive polyphenols of pomegranate and has the potential to cure different ailments related to the CVS system. The current research work was envisioned to predict the targeting efficiency of punicalagin (PG) nanoparticles to the macrophages. For this, we select mannose decorated PLGA-punicalagin nanoparticles (Mn-PLGA-PG) and before formulation we predict the targeting efficiency of this nanocarrier by in-silico analysis. Authors initiated in-silico analysis on macrophage mannose receptor to be acquainted with the binding affinity. In-silico docking studies of macrophage mannose receptor and punicalagin showed binding interaction on its surface with a docking score of -4.00.PG interacts with hydrogen bonds to the charged residue ASP668 and GLY666 and polar residue GLN760 residue of Mn receptor. Mannose with a docking score of -5.811 and interacting with four hydrogen bonds to the mannose receptor of macrophage with two negatively charged residues GLU706, GLU719 also with two hydrophobic residues VAL716, PHE708 and in PLGA, it showed a -4.334-docking score. In trajectory analysis, the complex RMSD of macrophage while stabilizing the structure till 100ns, Mn receptor-PG found within the range of 4.6 Å. Initial fluctuation in RMSD noticed to 4.95 Åat 20ns which started stabilizing with timescale. In the total of 100ns, initially up to 40ns the PG (ligand) deviated to 1.2Å after 40ns, it is noted that the ligand RMSD was almost constant and started stabilizing and at 100ns it was 1.03Å. Findings depict that this nanocarrier could be a promising lead molecule to regulate the incidence of drug induced neutropenia.
Locomotor Activity Of Ixodes Ricinus Females In 900 Mhz Electromagnetic Field
Authors: Vargová Blažena , Majláth Igor , Kurimský Juraj , Cimbala Roman , Zbojovský Ján , Tryjanowski Piotr , Majláthová Viktória 
Published: March 2022

Abstract

Mobile telecommunications technologies have become an indispensable part of people´s lives of all ages around the world. They affect personal life and social interactions and are a work tool in the work routine. The requirements for network availability and the quality of the Internet connection are constantly increasing, to which telecommunications providers are responding. Humans and wildlife live in an environment with the permanent presence of electromagnetic radiation with just a minor knowledge on the impact this radiation has. The aim of our study was to investigate the effect of 900 MHz electromagnetic field (EMF) on the exploratory behavior of female Ixodes ricinus ticks under laboratory conditions. Experiments were realized in the radiation-shielded tube (RST) test radiation-shielded circular open field arena, altogether 480 female I. ricinus ticks were tested. While in the RST arena we observed only a tendency to move towards the irradiated part of the arena, in the open field arena the time spent in the part exposed to EMF and the trajectory passed was significantly longer.
Symptoms of Anxiety and Depression Predicting Fall-Related Outcomes Among Older Americans: A Longitudinal Study
Authors: luo yuqian , Miyawaki Christina , Valimaki Maritta , Tang Siyuan , Sun Hongyu , Liu Minhui 
Published: March 2022

Abstract
Background
Anxiety symptoms and depressive symptoms are associated with fear of falling and fear of falling-related activity restriction. However, it remains unknown whether anxiety or depressive symptoms alone could predict fear of falling and activity restrictions in older adults. We sought to determine if anxiety and depressive symptoms alone could be an independent predictor of fear of falling and activity restriction in community-dwelling older adults.
Methods
This longitudinal analysis used waves 5 (time 1, [T1])and 6 (time 2, [T2], one year from T1) data (N = 6,376) from the National Health and Aging Trends Study (NHATS). We included participants who had completed interviews in both waves. The Generalized Anxiety Disorder Scale − 2 and Patient Health Questionnaire − 2 were used to assess anxiety symptoms and depressive symptoms, respectively. Interview questions included demographics, health-related data, and fall worry levels (no fear of falling, fear of falling but no activity restriction, and activity restriction). Using multinomial logistic regression models, we examined whether anxiety symptoms (T1) predicted fear of falling and activity restriction (T2), after adjusting for depressive symptoms, fall worry levels, and covariates, and also whether depressive symptoms predicted future fear of falling and activity restriction adjusting for anxiety symptoms, previous fall worry levels, and covariates.
Results
In the first cohort (T1, mean age: 78 years, 58.1% female), 10% and 13% of participants reported anxiety and depressive symptoms, and 19% and 10% of participants experienced fear of falling but not activity restriction and activity restriction in the second cohort (T2), respectively. Participants with anxiety symptoms at T1 had a 1.33 times higher risk of fear of falling (95% CI = 1.02–1.72) and 1.41 times higher risk of activity restriction (95% CI = 1.04–1.90) at T2 after controlling for depressive symptoms compared with participants without anxiety symptoms. show any significance after adjusting for anxiety symptoms.
Conclusions
Anxiety symptoms seemed to be an independent risk factor for future fear of falling and activity restriction, while depressive symptoms were not. To prevent future fear of falling and activity restriction, we should pay special attention to individuals with anxiety
Quasi-Periodic Eruptions:
Unstable Mass Transfer from a Main-Sequence Star
Authors: Linial Itai , Sari Re'em 
Published: March 2022

Abstract
Quasi-periodic eruptions (QPEs) are enigmatic high amplitude bursts of X-ray radiation with a recurrence period of a few to several hours, recently discovered near the central supermassive black holes (SMBHs) of a few distant galaxies [1-3]. The periodic flares are naturally explained by a star on an eccentric orbit, shedding mass at each pericenter passage, resulting in a highly-modulated accretion luminosity. The energetics of each eruption indicate accretion of roughly 1e-7 M_sun and therefore an apparent evolution time of ~5000 years for a solar mass donor. Assuming stable mass transfer driven by the emission of gravitational waves, the mass-losing object must be a dense stellar object (white dwarf or Helium star) on a highly eccentric (e>0.95) orbit [4,5]. However, these objects are rare since emission of gravitational waves tends to circularize orbits. This led to the suggestion of more complicated scenarios involving two interacting stars on coplanar, counter-rotating orbits [6], or star-disk collisions [7]. Here we argue that QPEs are produced by a main-sequence star orbiting a SMBH on a mildly eccentric orbit (e~0.1). By relaxing the assumption of stable mass transfer, we break the equality between the gravitational wave timescale and the apparent evolution timescale, and therefore infer almost circular orbits which are more frequent. The unstable mass transfer implies that the observed QPEs will evolve within the next ~10 years - they will significantly brighten, and then cease to flare. This timescale is much shorter than the apparent lifetime, allowing for observational test of our predictions. Indeed, archival data of one QPE system shows that it was dimmer two decades ago [2]. We show that a combination of two body scattering and gravitational wave emission around SMBHs produces roughly 10^-6 yr-1 gal-1 stars on orbits that generate QPEs. Given our calculated lifetime of ~10 years, we obtain an abundance of order 1e-5 gal-1 consistent with the eROSITA blind QPE search [3].
Preoperative Risk Factors of Pelvic/Para-Aortic Lymph Node Metastases in Ovarian Cancer: A Multi-Center Retrospective Study
Authors: Xiong Xiaoming , Gao Yue , Wang Mengjie , Chi Jianhua , Jiao Xiaofei , Zeng Shaoqing , Chen Lingxi , Zhou Qi , Wang Li , Xia Yu , Zhang Wei , Fang Yong , Gao Qinglei 
Published: March 2022

Abstract
Background
Ovarian cancer (OC) patients benefited little from systematic pelvic/para-aortic lymph node dissection during surgery, which may attribute to the difficulties in identifying the patients with pelvic/para-aortic lymph node metastases (LNM) preoperatively. Unfortunately, risk factors predicting the pelvic/para-aortic LNM in OC patients are lacking now. The purpose of this study was to investigate preoperative risk factors of predicting OC patients at high risk of pelvic/para-aortic LNM and preventing OC patients at low risk of LNM from receiving unnecessary lymphadenectomy.
Methods
Patients diagnosed with OC between January 2012 and May 2020 from Tongji Hospital, Chongqing Cancer Hospital, and Tumor Hospital of Henan, were retrospectively reviewed. Demographics, pathology, and preoperative laboratory features were extracted from Electronic-Medical Records. The correlation between factors and LNM was assessed by chi-square test and multivariate logistic regression analysis.
Results
A total of 827 patients were included in this study. Univariate analysis indicated 23 preoperative features were significantly associated with LNM. Multivariate analysis showed that BMI ≥ 23.23 kg/m2 (odds ratio [OR], 2.082; 95% confidence interval [CI], 1.448–2.995), ascites (OR, 3.022, 95% CI, 2.058–4.438), CA125 ≥ 432.15 U/ml (OR, 4.665, 95% CI, 3.158–6.891), neutrophil count ≥ 2.965*109/L (OR, 2.882, 95% CI, 1.606–5.172), lymphocyte count < 1.30*109/L (OR, 1.554, 95% CI, 1.086–2.223), and monocyte count ≥ 0.415*109/L (OR, 1.506, 95% CI, 1.047–2.166) were independent risk factors in predicting LNM. The area under the curve (AUC) of predicting LNM by combining these factors was 0.836 (95% CI 0.808–0.864). The predicting performance of this model was also promising in OC patients with early-stage (stage I-II) (AUC, 0.809, 95% CI, 0.619–1.000) and advanced-stage (stage III-IV) (AUC, 0.764, 95% CI, 0.723–0.805). Furthermore, patients with 0–3 risk factors had significantly lower LNM rates than those of patients with 4–6 risk factors (15.40% vs 58.92%, p < 0.001).
Conclusions
Preoperative BMI, ascites, CA125 level, neutrophil count, lymphocyte count, and monocyte count can predict the risk of LNM and facilitate decision-making of systematic lymphadenectomy in OC patients, which could avoid unnecessary lymphadenectomy.