bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a training program for occupational health professionals on the cognitions and perceptions of workers: a randomized controlled trial
Authors: de Wit Mariska , Horreh Bedra , Hulshof Carel T. J. , Wind Haije , de Boer Angela G. E. M. 
Published: January 2022

Abstract
Purpose
To evaluate the effects of a training program for occupational health professionals (OHPs) on their ability to identify the cognitions and perceptions of workers with a chronic disease that may hinder work participation, and on their ability to recommend evidence-based interventions aimed at the identified cognitions and perceptions.

Methods
A randomized controlled trial was conducted in which OHPs were randomly assigned to a training program on the cognitions and perceptions of workers with a chronic disease (n = 29) or to a control group that did not receive training (n = 30). Participants received home assignments in which they had to identify the cognitions and perceptions of workers in video vignettes and had to indicate which interventions they would recommend to foster work participation. A generalized linear model repeated measures ANOVA was conducted to study the effects of the training program.

Results
The results of the analyses showed an increase in the ability to identify the cognitions and perceptions of workers of OHPs who received the training compared to the control group (p < 0.001). The results also showed an increased ability to recommend evidence-based interventions aimed at these cognitions and perceptions (p < 0.001) as a result of participation in the training.

Conclusion
The training program helps OHPs to identify cognitions and perceptions and to recommend evidence-based interventions. This can support them in their activities to increase the work participation of workers with a chronic disease.
Risk of colonoscopic post-polypectomy bleeding in patients on single antiplatelet therapy: systematic review with meta-analysis
Authors: Valvano Marco , Fabiani Stefano , Magistroni Marco , Mancusi Antonio , Longo Salvatore , Stefanelli Gianpiero , Vernia Filippo , Viscido Angelo , Romano Silvio , Latella Giovanni 
Published: January 2022

Abstract
Background
It was not yet fully established whether the use of antiplatelet agents (APAs) is associated with an increased risk of colorectal post-polypectomy bleeding (PPB). Temporarily, discontinuation of APAs could reduce the risk of PPB, but at the same time, it could increase the risk of cardiovascular disease recurrence. This study aimed to assess the PPB risk in patients using APAs compared to patients without APAs or anticoagulant therapy who had undergone colonoscopy with polypectomy.

Methods
A systematic electronic search of the literature was performed using PubMed/MEDLINE, Scopus, and CENTRAL, to assess the risk of bleeding in patients who do not interrupt single antiplatelet therapy (P2Y12 inhibitors or aspirin) and undergone colonoscopy with polypectomy.

Results
Of 2417 identified articles, 8 articles (all of them were non-randomized studies of interventions (NRSI); no randomized controlled trials (RCT) were available on this topic) were selected for the meta-analysis, including 1620 patients on antiplatelet therapy and 13,321 controls. Uninterrupted APAs single therapy was associated with an increased risk of PPB compared to the control group (OR 2.31; CI 1.37–3.91). Patients on P2Y12i single therapy had a higher risk of both immediate (OR 4.43; CI 1.40–14.00) and delayed PPB (OR 10.80; CI 4.63–25.16) compared to the control group, while patients on aspirin single therapy may have a little to no difference increase in the number of both immediate and delayed PPB events.

Conclusions
Uninterrupted single antiplatelet therapy may increase the risk of PPB, but the evidence is very uncertain. The risk may be higher in delayed PPB. However, in deciding to discontinue APAs before colonoscopy with polypectomy, the potential higher risk of major adverse cardiovascular events should always be assessed.
Colorectal cancer pain upon diagnosis and after treatment: a cross-sectional comparison with healthy matched controls
Authors: Lopez-Garzon Maria , Postigo-Martin Paula , González-Santos Ángela , Arroyo-Morales Manuel , Achalandabaso-Ochoa Alexander , Férnández-Pérez Antonio Manuel , Cantarero-Villanueva Irene 
Published: January 2022

Abstract

Background
The current study sought to explore whether cancer pain (CP) already exists in patients at colorectal cancer (CRC) diagnosis before treatment compared with patients with colorectal cancer (CRC) after treatment and a healthy matched control group. The study also sought to examine whether factors related to physical health status could enhance pain processes.

Methods
An observational cross-sectional study was conducted following the STROBE checklist. Twenty-nine newly diagnosed and forty post-treatment patients with CRC and 40 healthy age/sex-matched controls were included for comparison. Pain, local muscle function, and body composition outcomes were assessed by a physiotherapist with > 3 years of experience. ANCOVA and Kruskal–Wallis tests were performed, with Bonferroni and Dunn-Bonferroni post hoc analyses and Cohen’s d and Hedge’s effect size, as appropriate.

Results
The analysis detected lower values of pressure pain threshold (PPT) points, the PPT index, and abdominal strength and higher values of self-reported abdominal pain in newly diagnosed patients, with even more marked results observed in the post-treatment patients, where lower lean mass and skeletal muscle index values were also found than those in the healthy matched controls (p < 0.05). In the post-treatment and healthy matched control groups, positive associations were observed between the PPT lumbar dominant side points and abdominal isometric strength and lean mass, and negative associations were observed between the lumbar dominant side points and body fat (p < 0.05).

Conclusion
Upon diagnosis, patients with CRC already show signs of hyperalgesia and central sensitization and deteriorated physical conditions and body composition, and this state could be aggravated by subsequent treatments.
The impact of intraoperative blood pressure variability on the risk of postoperative adverse outcomes in non-cardiac surgery: a systematic review
Authors: Putowski Zbigniew , Czok Marcelina , Krzych Łukasz J. 
Published: January 2022

AbstractHemodynamic stability during surgery seems to account for positive postoperative outcomes in patients. However, little is known about the impact of intraoperative blood pressure variability (IBPV) on the postoperative complications. The aim was to investigate whether IBPV is associated with the development of postoperative complications and what is the nature of this association. We conducted a systematic search in PubMed, Medical Subject Headings, Embase, Web of Science, SCOPUS, clinicaltrials.gov, and Cochrane Library on the 8th of April, 2021. We included studies that only focused on adults who underwent primarily elective, non-cardiac surgery in which intraoperative blood pressure variation was measured and analyzed in regard to postoperative, non-surgical complications. We identified 11 papers. The studies varied in terms of applied definitions of blood pressure variation, of which standard deviation and average real variability were the most commonly applied definitions. Among the studies, the most consistent analyzed outcome was a 30-day mortality. The studies presented highly heterogeneous results, even after taking into account only the studies of best quality. Both higher and lower IBPV were reported to be associated for postoperative complications. Based on a limited number of studies, IBPV does not seem to be a reliable indicator in predicting postoperative complications. Existing premises suggest that either higher or lower IBPV could contribute to postoperative complications. Taking into account the heterogeneity and quality of the studies, the conclusions may not be definitive.
Iron serum levels and iron homeostasis parameters in patients with nosocomial pneumonia treated with cefiderocol: post hoc analysis of the APEKS-NP study
Authors: Skaar Eric P. , Echols Roger , Matsunaga Yuko , Menon Anju , Portsmouth Simon 
Published: January 2022

AbstractCritically ill patients often present with low serum iron levels or anemia. We evaluated the impact of iron levels and iron homeostasis on the efficacy and safety of cefiderocol, an iron-chelator siderophore cephalosporin, in patients with nosocomial pneumonia in a post hoc analysis of the randomized, double-blind, Phase 3 APEKS-NP study (NCT03032380). Patients with Gram-negative nosocomial pneumonia received cefiderocol 2 g, 3-h infusion, q8h, or high-dose, extended-infusion meropenem 2 g, 3-h infusion, q8h, for 7–14 days. Efficacy and safety parameters, including specific iron homeostasis parameters (i.e., hepcidin, iron, total iron binding capacity, transferrin saturation), were analyzed according to baseline iron levels. In the cefiderocol and meropenem arms, 79.1% (117/148) and 83.3% (125/150) randomized patients, respectively, had low baseline serum iron levels. Rates of 14-day (12.3% [14/114] vs 11.6% [14/121]) and 28-day all-cause mortality (20.5% [23/112] vs 19.0% [23/121]), clinical cure (63.2% [72/114] vs 67.2% [82/122]), and microbiological eradication (43.6% [41/94] vs 48.1% [51/106]) at test of cure were similar in cefiderocol vs meropenem arms, respectively. In the overall safety population, rates of anemia-related adverse events were similar (cefiderocol arm 18.2% [27/148], meropenem arm 18.7% [28/150]). Changes from baseline to test of cure in hepcidin, iron, total iron binding capacity, and transferrin saturation were similar between treatment arms. Cefiderocol treatment did not affect iron homeostasis, and its efficacy and safety were not influenced by baseline serum iron levels. Clinicaltrials.gov registration: NCT03032380. Date of registration: 26 January 2017.
Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 2
Authors: Tozawa Akiko , Kimura Fuminori , Takai Yasushi , Nakajima Takeshi , Ushijima Kimio , Kobayashi Hiroaki , Satoh Toyomi , Harada Miyuki , Sugimoto Kohei , Saji Shigehira , Shimizu Chikako , Akiyama Kyoko , Bando Hiroko , Kuwahara Akira , Furui Tatsuro , Okada Hiroshi , Kawai Koji , Shinohara Nobuo , Nagao Koichi , Kitajima Michio , Suenobu Souichi , Soejima Toshinori , Miyachi Mitsuru , Miyoshi Yoko , Yoneda Akihiro , Horie Akihito , Ishida Yasushi , Usui Noriko , Kanda Yoshinobu , Fujii Nobuharu , Endo Makoto , Nakayama Robert , Hoshi Manabu , Yonemoto Tsukasa , Kiyotani Chikako , Okita Natsuko , Baba Eishi , Muto Manabu , Kikuchi Iwaho , Morishige Ken-ichirou , Tsugawa Koichiro , Nishiyama Hiroyuki , Hosoi Hajime , Tanimoto Mitsune , Kawai Akira , Sugiyama Kazuhiko , Boku Narikazu , Yonemura Masato , Hayashi Naoko , Aoki Daisuke , Suzuki Nao , Osuga Yutaka 
Published: January 2022

AbstractThe Japan Society of Clinical Oncology (JSCO) published the “JSCO Clinical Practice Guidelines 2017 for Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer Patients” in 2017. This was the first guideline in cancer reproductive medicine in Japan. In the field of cancer reproductive medicine, close cooperation between an oncologist and a physician for reproductive medicine is important from before treatment initiation until long after treatment. The guideline takes into consideration disease specificity and provides opinions from the perspective of oncologists and specialists in reproductive medicine that are in line with the current state of the Japanese medical system. It is intended to serve as a reference for medical staff in both fields regarding the availability of fertility preservation therapy before the start of cancer treatment. Appropriate use of this guideline makes it easier to determine whether fertility preservation therapy is feasible and, ultimately, to improve survivorship in childhood, adolescent, and young adult cancer patients. In this article (Part 2), we describe details by organ/system and also for pediatric cancer.
GLONASS precise orbit determination with identification of malfunctioning spacecraft
Authors: Bury Grzegorz , Sośnica Krzysztof , Zajdel Radosław , Strugarek Dariusz 
Published: January 2022

AbstractDue to the continued development of the GLONASS satellites, precise orbit determination (POD) still poses a series of challenges. This study examines the impact of introducing the analytical tube-wing model for GLONASS-M and the box-wing model for GLONASS-K in a series of hybrid POD strategies that consider both the analytical model and a series of empirical parameters. We assess the perturbing accelerations acting on GLONASS spacecraft based on the analytical model. All GLONASS satellites are equipped with laser retroreflectors for satellite laser ranging (SLR). We apply the SLR observations for the GLONASS POD in a series of GNSS + SLR combined solutions. The application of the box-wing model significantly improves GLONASS orbits, especially for GLONASS-K, reducing the STD of SLR residuals from 92.6 to 27.6 mm. Although the metadata for all GLONASS-M satellites reveal similar construction characteristics, we found differences in empirical accelerations and SLR offsets not only between GLONASS-M and GLONASS-M+ but also within the GLONASS-M+ series. Moreover, we identify satellites with inferior orbit solutions and check if we can improve them using the analytical model and SLR observations. For GLONASS-M SVN730, the STD of the SLR residuals for orbits determined using the empirical solution is 48.7 mm. The STD diminishes to 41.2 and 37.8 mm when introducing the tube-wing model and SLR observations, respectively. As a result, both the application of the SLR observations and the analytical model significantly improve the orbit solution as well as reduce systematic errors affecting orbits of GLONASS satellites.
Spinoffs’ alliance network growth beyond parental ties: performance diminishing, then performance enhancing
Authors: Zarea Fazlelahi Forough , Burgers J. Henri , Obschonka Martin , Davidsson Per 
Published: January 2022

AbstractSpinoff firms are a common phenomenon in entrepreneurship where employees leave incumbent parent firms to found their own. Like other types of new firms, such new spinoffs face liabilities of newness and smallness. Previous research has emphasised the role of the initial endowments from their parent firm to overcome such liabilities. In this study, we argue and are the first to show, that, in addition to such endowments, growing an alliance network with firmsother than their parents’is also critical for spinoff performance. Specifically, we investigate the performance effect of alliance network growth in newly founded spinoffs using a longitudinal sample of 248 spinoffs and 3370 strategic alliances in the mining industry. Drawing on theory based on the resource adjustment costs of forming alliances, we posit and find a U-shaped relationship between the alliance network growth and spinoff performance, above and beyond the parent firm’s influence. We further hypothesise and find that performance effects become stronger with increased time lags between alliance network growth and spinoff performance, and when spinoffs delay growing their alliance networks. Implications for theory and practice are discussed.
When Elon Musk Changes his Tone, Does Bitcoin Adjust Its Tune?
Authors: Huynh Toan Luu Duc 
Published: January 2022

AbstractWe present a textual analysis that explains how Elon Musk’s sentiments in his Twitter content correlates with price and volatility in the Bitcoin market using the dynamic conditional correlation-generalized autoregressive conditional heteroscedasticity model, allowing less sensitive to window size than traditional models. After examining 10,850 tweets containing 157,378 words posted from December 2017 to May 2021 and rigorously controlling other determinants, we found that the tone of the world’s wealthiest person can drive the Bitcoin market, having a Granger causal relation with returns. In addition, Musk is likely to use positive words in his tweets, and reversal effects exist in the relationship between Bitcoin prices and the optimism presented by Tesla’s CEO. However, we did not find evidence to support linkage between Musk’s sentiments and Bitcoin volatility. Our results are also robust when using a different cryptocurrency, i.e., Ether this paper extends the existing literature about the mechanisms of social media content generated by influential accounts on the Bitcoin market.
Measuring the effectiveness of online problem solving for improving academic performance in a probability course
Authors: González José Antonio , Giuliano Mónica , Pérez Silvia N. 
Published: January 2022

AbstractResearch on impact in student achievement of online homework systems compared to traditional methods is ambivalent. Methodological issues in the study design, besides of technological diversity, can account for this uncertainty. Hypothesis This study aims to estimate the effect size of homework practice with exercises automatically provided by the ‘e-status’ platform, in students from five Engineering programs. Instead of comparing students using the platform with others not using it, we distributed the subject topics into two blocks, and created nine probability problems for each block. After that, the students were randomly assigned to one block and could solve the related exercises through e-status. Teachers and evaluators were masked to the assignation. Five weeks after the assignment, all students answered a written test with questions regarding all topics. The study outcome was the difference between both blocks’ scores obtained from the test. The two groups comprised 163 and 166 students. Of these, 103 and 107 respectively attended the test, while the remainder were imputed with 0. Those assigned to the first block obtained an average outcome of −1.85, while the average in the second block was −3.29 (95% confidence interval of difference, −2.46 to −0.43). During the period in which they had access to the platform before the test, the average total time spent solving problems was less than three hours. Our findings provide evidence that a small amount of active online work can positively impact on student performance.
Protecting against researcher bias in secondary data analysis: challenges and potential solutions
Authors: Baldwin Jessie R. , Pingault Jean-Baptiste , Schoeler Tabea , Sallis Hannah M. , Munafò Marcus R. 
Published: January 2022

AbstractAnalysis of secondary data sources (such as cohort studies, survey data, and administrative records) has the potential to provide answers to science and society’s most pressing questions. However, researcher biases can lead to questionable research practices in secondary data analysis, which can distort the evidence base. While pre-registration can help to protect against researcher biases, it presents challenges for secondary data analysis. In this article, we describe these challenges and propose novel solutions and alternative approaches. Proposed solutions include approaches to (1) address bias linked to prior knowledge of the data, (2) enable pre-registration of non-hypothesis-driven research, (3) help ensure that pre-registered analyses will be appropriate for the data, and (4) address difficulties arising from reduced analytic flexibility in pre-registration. For each solution, we provide guidance on implementation for researchers and data guardians. The adoption of these practices can help to protect against researcher bias in secondary data analysis, to improve the robustness of research based on existing data.
Parent, Teacher and Observational Reports of Emotional and Behavioral Problems in Young Autistic Children
Authors: Palmer Melanie , Tarver Joanne , Carter Leno Virginia , Paris Perez Juan , Frayne Margot , Slonims Vicky , Pickles Andrew , Scott Stephen , Charman Tony , Simonoff Emily 
Published: January 2022

AbstractEmotional and behavioral problems (EBPs) frequently occur in young autistic children. Discrepancies between parents and other informants are common but can lead to uncertainty in formulation, diagnosis and care planning. This study aimed to explore child and informant characteristics are associated with reported child EBPs across settings. Participants were 83 4–8-year-old autistic children and their parents and teachers in the Autism Spectrum Treatment and Resilience (ASTAR) study. Questionnaires of child EBPs were completed by parents and teachers, and self-reported parenting stress and wellbeing measures were obtained. An observation of parent–child/researcher-child interaction was also completed. Parents reported more EBPs than teachers and parent-teacher agreement was low, particularly for emotional problems. Greater parenting stress and being verbal was associated with more parent- but not teacher-reported EBPs. More observed behaviors that challenge were displayed by minimally verbal children. More parenting stress could be associated with the presence of more EBPs in the home; alternatively, parenting stress may confound reports. It is essential for assessments of EBPs in autistic children to take a multi-informant approach. Better understanding of the associations between informant characteristics and informant discrepancies of EBPs is needed.
Diffusion and Superdiffusion from Hydrodynamic Projections
Authors: Doyon Benjamin 
Published: January 2022

AbstractHydrodynamic projections, the projection onto conserved charges representing ballistic propagation of fluid waves, give exact transport results in many-body systems, such as the exact Drude weights. Focussing one one-dimensional systems, I show that this principle can be extended beyond the Euler scale, in particular to the diffusive and superdiffusive scales. By hydrodynamic reduction, Hilbert spaces of observables are constructed that generalise the standard space of conserved densities and describe the finer scales of hydrodynamics. The Green–Kubo formula for the Onsager matrix has a natural expression within the diffusive space. This space is associated with quadratically extensive charges, and projections onto any such charge give generic lower bounds for diffusion. In particular, bilinear expressions in linearly extensive charges lead to explicit diffusion lower bounds calculable from the thermodynamics, and applicable for instance to generic momentum-conserving one-dimensional systems. Bilinear charges are interpreted as covariant derivatives on the manifold of maximal entropy states, and represent the contribution to diffusion from scattering of ballistic waves. An analysis of fractionally extensive charges, combined with clustering properties from the superdiffusion phenomenology, gives lower bounds for superdiffusion exponents. These bounds reproduce the predictions of nonlinear fluctuating hydrodynamics, including the Kardar–Parisi–Zhang exponent 2/3 for sound-like modes, the Levy-distribution exponent 3/5 for heat-like modes, and the full Fibonacci sequence.