bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liver transplantation for intrahepatic and hilar cholangiocellular carcinoma: Most recent updates in the literature
Authors: Eguchi Susumu , Hidaka Masaaki , Hara Takanobu , Matsushima Hajime , Soyama Akihiko 
Published: March 2022

AbstractLiver transplantation (LT) for non‐hepatocellular carcinoma is still a debatable indication. Recently, hilar cholangiocellular carcinoma (hCCC) has attracted interest as a new indication for LT, but LT in this case should be carefully considered. Based on the recent meta‐analysis for intrahepatic CCC (IHCCC) and our results from incidental IHCCC transplanted for other diseases such as primary sclerosing cholangitis, the indication for LT for IHCCC should be limited to a single tumor less than 2 cm. For hCCC, with pre‐transplant chemoradiotherapy and careful selection criteria, long‐term survival after LT could be attained. In order to improve the results of LT for intrahepatic and hCCC, further studies are required on the ingenuity of immunosuppressive therapy combined with chemotherapy, and optimal treatment methods to prevent recurrence, as well as initial case selection.
Application and utility of surgical techniques for cystic plate isolation in liver surgery
Authors: Tokumitsu Yukio , Tamesa Takao , Shindo Yoshitaro , Sakamoto Kazuhiko , Nagano Hiroaki 
Published: March 2022

AbstractOne of the most important areas of anatomical knowledge for liver surgery is the plate system in the hilar area. Four plates comprise the hilar area plate system: the hilar plate, cystic plate, umbilical plate, and Arantian plate. Based on the theory that the cystic plate is continuous with the hilar plate, isolation of the cystic plate can be applicable to various scenarios in liver surgery. We describe herein the procedure and usefulness of cystic plate isolation to approach the hilar plate, in both open and laparoscopic surgeries. This isolation can be applied in various manners. First, cystic plate traction can facilitate the Glissonian approach, drawing out the extrahepatic Glissonian pedicles and thus lengthening the pedicle, and facilitate isolation of these pedicles. Second, inflow control can be obtained by applying the cystic plate traction method to the Glissonian approach. This is suitable to control hepatic inflow when there is no need to divide vessels such as lymph node dissection or vascular resection and reconstruction. Third, the Glissonian approach can be used in surgery for hepatocellular carcinoma patients with portal thrombosis. The cystic plate traction method potentially avoids injury to the Glissonian pedicle that would cause unnecessary bleeding, and is thus particularly efficient for advanced cancers such as hepatocellular carcinoma patients with portal thrombosis and collateral vessels around the area of obstruction in the Glissonian sheath. In this article, we focused on our anatomical knowledge and technical tips for making use of cystic plate isolation in liver surgery.
White light emission from AIE‐active luminescent organic materials
Authors: Kumari Beena , Dahiwadkar Rahul , Kanvah Sriram 
Published: March 2022

AbstractFluorescent organic materials that exhibit unique aggregation‐induced emission have been utilized for various applications, including white light emission (WLE). The materials typically rely on composite designs involving a mixture of compounds emitting at different wavelengths of light. To overcome the limitations offered by the design of such composite mixtures, tremendous efforts were also emphasized in developing single‐molecule substrates that emit white light. The white light by either method is typically controlled by the solvent polarity, energy and charge transfer, host‐guest interactions, gelation, or embedding in the polymer or organic frameworks. This article briefly reviews various molecules exhibiting aggregation‐induced emission behavior and emitting white light.
Uncertainty estimation in deep learning‐based property models: Graph neural networks applied to the critical properties
Authors: Aouichaoui Adem R. N. , Mansouri Seyed Soheil , Abildskov Jens , Sin Gürkan 
Published: March 2022

AbstractDeep learning and graph‐based models have gained popularity in various life science applications such as property modeling, achieving state‐of‐the‐art performance. However, the quantification of prediction uncertainty in these models is less studied and is not applied in the low dataset size regime, which characterizes many chemical engineering‐related molecular properties. In this work, we apply two graph‐based models to model the critical‐ temperature, pressure, and volume and apply three techniques (the bootstrap, the ensemble, and the dropout) to quantify the prediction uncertainty. The overall model confidence is evaluated using the coverage. The results suggest that graph‐based models perform better compared with current group‐contribution‐based property modeling techniques while eliminating the tedious task of developing molecular descriptors.
Recent Advances in the Catalytic Umpolung Carboxylation of Allylic Alcohol Derivatives with Carbon Dioxide
Authors: You Yong , Mita Tsuyoshi 
Published: March 2022

AbstractAllylic alcohols and their derivatives (e. g. halides, acetates, and pivalates) are readily available organic compounds that are frequently employed in organic synthesis, and especially in Tsuji‐Trost‐type allylic substitution reactions. These allylic substrates add oxidatively to transition metals such as Pd to form π‐allyl metal species, which can act as suitable electrophiles for several nucleophilic counterparts. However, under reductive conditions, the π‐allyl metal species instantly become nucleophilic and react with various electrophiles including the rather stable CO2, which is an abundant, inexpensive, non‐toxic, and renewable carbon source in organic synthesis. When CO2 is incorporated in allylic compounds, synthetically useful β,γ‐unsaturated carboxylic acid derivatives are obtained exclusively. In this review, we focus on the recent advances in such catalytic umpolung carboxylations of allyl alcohols, acetates, pivalates, and halides with CO2 under thermal, photochemical, and electrochemical conditions.
White matter hyperintensities and longitudinal cognitive decline in cognitively normal populations and across diagnostic categories: A meta‐analysis, systematic review, and recommendations for future study harmonization
Authors: Roseborough Austyn D , Saad Lorenzo , Goodman Maren , Cipriano Lauren E , Hachinski Vladimir C , Whitehead Shawn N 
Published: March 2022

AbstractIntroductionThe primary aim of this paper is to improve the clinical interpretation of white matter hyperintensities (WMHs) and provide an overarching summary of methodological approaches, allowing researchers to design future studies targeting current knowledge gaps.MethodsA meta‐analysis and systematic review was performed investigating associations between baseline WMHs and longitudinal cognitive outcomes in cognitively normal populations, and populations with mild cognitive impairment (MCI), Alzheimer's disease (AD), and stroke.ResultsBaseline WMHs increase the risk of cognitive impairment and dementia across diagnostic categories and most consistently in MCI and post‐stroke populations. Apolipoprotein E (APOE) genotype and domain‐specific cognitive changes relating to strategic anatomical locations, such as frontal WMH and executive decline, represent important considerations. Meta‐analysis reliability was assessed using multiple methods of estimation, and results suggest that heterogeneity in study design and reporting remains a significant barrier.DiscussionRecommendations and future directions for study of WMHs are provided to improve cross‐study comparison and translation of research into consistent clinical interpretation.
Bioactive La(III), Er(III), Yb(III), Ru(III), and Ta(V) complexes of new organometallic Schiff base: Preparation, structural characterization, antibacterial, anticancer activities, and MOE studies
Authors: Deghadi Reem G. , Mohamed Gehad G. , Mahmoud Nessma F. 
Published: March 2022

AbstractBioactive complexes [La(L)(H2O)3Cl]Cl2.2H2O (1), [Er(L)(H2O)3Cl]Cl2 (2), [Yb(L)(H2O)2Cl2]Cl.4H2O (3), [Ru(L)(H2O)2Cl2]Cl.H2O (4), and [Ta(L)(H2O)Cl5] (5) have been prepared from 2‐acetylferrocene derivative Schiff base (L) and characterized with different spectroscopic tools. Infrared (IR) spectral data proved the action of the ligand as a neutral bidentate Schiff base, coordinating via N‐azomethine and N‐pyrazole. Ta(V)‐complex was eight‐coordinated complex, whereas others were six‐coordinated complexes. Molar conductance results showed that La(III) and Er(III) chelates were 1:2 electrolytes, Yb(III) and Ru(III) chelates were 1:1 electrolytes, and Ta(V) chelate was non‐electrolyte. Thermal behavior of all compounds was characterized by thermogravimetric analysis/differential thermogravimetric analysis (TG/DTG) curves with mass loss related to dehydration, coordination, and decomposition steps. Growth inhibitory effect and IC50 values of compounds toward MCF‐7 cancer cell line were measured, and the data revealed that all complexes showed higher anticancer activity than free ligand. The lowest IC50 value was 4.5 μg/mL for La(III) and Ru(III) complexes. Furthermore, almost complexes showed good activities against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus species with inhibition zone diameter in the range of 10–15 mm/mg. While, they had no antifungal activities against Candida albicans and Aspergillus flavas species. Finally, the strong binding affinity of ligand and its complexes with different protein receptors was confirmed by MOE studies.
TMU‐16‐NH2MOF modified with organic ligands for stabilization of copper nanoparticles: An efficient and crystalline heterogeneous catalyst for the synthesis of propargyl amines derivatives under green reaction condition
Authors: Kiani Ameneh , Alinezhad Heshmatollah , Ghasemi Shahram 
Published: March 2022

AbstractFunctionalization of metal–organic framework (MOF) with various organic molecules to reinforce its surface potential in adsorption and stabilization of transition metal nanoparticles (NPs) is of great attention in creating/supporting ions metal within their framework and converting them into efficient heterogeneous catalysts. Here, we used a hybrid of inorganic–organic MOF (TMU‐16‐NH2) as an unparalleled compound for designing an efficient catalyst with nanoarchitecture via covalent functionalization of urea and 1,3‐propane sultone ligands. This hybrid nanoporous MOF was further engaged as a support in the synthesis and stabilization of Cu NPs on its surface, and then, the obtained Cu‐supported MOF was applied as a heterogeneous catalyst in the synthesis of propargyl amines derivatives under green reaction conditions with efficient recyclability.
Introduction of a crystalline block as a strategy to increase swelling resistance and dimensional stability of sulfonated copolyimide
Authors: Sapegin Denis Andzheevich , Gubanova Galina Nikolaevna , Vlasova Elena Nikolaevna , Zaharova Natalya Vladimirovna , Afanas'eva Nadezhda Vasil'evna , Popova Elena Nikolaevna , Sokolova Maria Petrovna , Lavrentyev Viktor Konstantinovich , Primachenko Oleg Nikolaevich , Kononova Svetlana Viktorovna 
Published: March 2022

AbstractThe introduction of blocks inclined to form areas of high crystallinity into the sulfonated block co‐polyimide is investigated as a prospective strategy to increase swelling resistance and dimensional stability of the polymer in application to the proton exchange membranes development. The novel copolymer with the highly crystalline block was obtained and characterized by the means of static and dynamic light scattering, IR spectroscopy, thermal gravimetric analysis and differential scanning calorimetry. The structural and morphological features of the obtained copolymer were investigated with X‐ray diffraction analysis and atomic force microscopy. Transport properties of the co‐polyimide are evaluated in terms of pervaporation, proton conductivity measurements and dielectric spectroscopy experiments. The article aims at the evaluation of the influence of the high‐crystalline block introduction on morphological, transport and physical properties of the sulfonated copolymer. The properties of the obtained crystalline sulfonated copolymer are compared to the ones of the similar amorphous polyimide. The studied crystalline copolymer showed constancy of the proton conductivity values in the broad range of temperatures (20–120°C, RMSD of 0.23%) and relative humidity values.
Peripheral γδ T Cells Regulate Neutrophil Expansion and Recruitment in Experimental Psoriatic Arthritis
Authors: Nguyen Cuong Thach , Furuya Hiroki , Das Dayasagar , Marusina Alina I. , Merleev Alexander A. , Ravindran Resmi , Jalali Zahra , Khan Imran H. , Maverakis Emanual , Adamopoulos Iannis E. 
Published: March 2022

ObjectiveThis study was undertaken to identify the mechanistic role of γδ T cells in the pathogenesis of experimental psoriatic arthritis (PsA).MethodsIn this study, we performed interleukin‐23 (IL‐23) gene transfer in wild‐type (WT) and T cell receptor δ–deficient (TCRδ−/−) mice and conducted tissue phenotyping in the joint, skin, and nails to characterize the inflammatory infiltrate. We further performed detailed flow cytometry, immunofluorescence staining, RNA sequencing, T cell repertoire analysis, and in vitro T cell polarization assays to identify regulatory mechanisms of γδ T cells.ResultsWe demonstrated that γδ T cells support systemic granulopoiesis, which is critical for murine PsA‐like pathology. Briefly, γδ T cell ablation inhibited the expression of neutrophil chemokines CXCL1 and CXCL2 and neutrophil CD11b+Ly6G+ accumulation in the aforementioned PsA‐related tissues. Although significantly reduced expression of granulocyte–macrophage colony‐stimulating factor (GM‐CSF) and IL‐17A was detected systemically in TCRδ−/− mice, no GM‐CSF+/IL‐17A+ γδ T cells were detected locally in the inflamed skin or bone marrow in WT mice. Our data showed that nonresident γδ T cells regulate the expansion of an CD11b+Ly6G+ neutrophil population and their recruitment to joint and skin tissues, where they develop hallmark pathologic features of human PsA.ConclusionOur findings do not support the notion that tissue‐resident γδ T cells initiate the disease but demonstrate a novel role of γδ T cells in neutrophil regulation that can be exploited therapeutically in PsA patients.
Ethylene Glycol as an Antifreeze Additive and Corrosion Inhibitor for Aqueous Zinc‐Ion Batteries
Authors: Nguyen Thanh Tran Thuy , Zhao Maosen , Geng Shujiang , Ivey Douglas G. 
Published: March 2022

AbstractAqueous zinc‐ion batteries are promising candidates for portable and large‐scale applications because of their intrinsically high safety, low cost and high theoretical energy density. However, existing aqueous zinc‐ion batteries usually suffer from zinc corrosion and poor performance at subzero temperatures. Herein, to address these problems, the electrolyte in aqueous zinc‐ion batteries (1 M ZnSO4) is modified by adding suitable amounts of ethylene glycol. The addition of ethylene glycol improves the antifreezing ability of the aqueous electrolyte and increases the conductivity of electrolyte at low temperatures. Ethylene glycol serves two purposes, as an antifreeze additive to significantly enhance the capacity of batteries at low temperatures and as a corrosion inhibitor to suppress zinc corrosion and byproduct precipitation. This work offers a facile strategy to realize aqueous zinc‐ion batteries with good performance at low temperatures.
A conceptual framework for blockchain‐based sustainable supply chain and evaluating implementation barriers: A case of the tea supply chain
Authors: Mangla Sachin Kumar , Kazançoğlu Yiğit , Yıldızbaşı Abdullah , Öztürk Cihat , Çalık Ahmet 
Published: March 2022

AbstractThe increasing population and income inequality in the last decades have made it necessary to focus on the concept of sustainability. In the changing world order, with economic crises, instabilities, pandemics, and social media, sustainability awareness differs significantly from past years. In addition, developing new technologies and concepts (big data, blockchain, IoT, robotic, etc.) plays a crucial role in meeting social awareness in terms of sustainability. Food sustainability is also one of the most important pillars in this concept. The integration of new technologies in agriculture and food chains will enable the current world population to use resources more efficiently and sustainably. Blockchain, one of the technologies that emerged with the arrival of Industry 4.0, is a technology that can be used effectively in many sectors. Particularly in supply chain networks, it is seen as a technology that supports the sustainability concept due to its features such as decentralization, reliability, transparency, consensus standards, and traceability. However, since blockchain is an immature and new technology, there are some challenges with integrating it into existing conventional systems. This study aims to present a conceptual framework for the integration of blockchain technology to establish a sustainable tea supply chain, define possible actions, and prioritize the possible risks that may arise in this integration process; this will be done through the Spherical Fuzzy Analytic Hierarchy Process (SF‐AHP) approach. In this context, initially, the current tea supply chain will be considered and the activities carried out will be defined in terms of technological, environmental, and strategic sustainability. Then, the design that includes the integration of all activities with blockchain technology is presented. The proposed design covers the entire tea supply chain from end to end and is considered with regard to all sustainability dimensions. In the proposed framework, barriers that may be encountered and risks that may arise at each stage of the tea supply chain process are identified; managerial implications are then presented to eliminate these risks. To enhance the use of the recommendations made, risks and barriers are prioritized with SF‐AHP management. Thus, the problems that need to be solved primarily in the technological transformation process can be evaluated more clearly. The proposed theoretical framework is expected to extend to all agricultural practices and support technological advances throughout the agricultural sector.
What drives and curbs brownwashing?
Authors: Huang Yinglin , Francoeur Claude , Brammer Stephen 
Published: March 2022

AbstractNumerous studies have investigated the factors that drive or curb greenwashing activities, but few have discussed the other side of the coin, brownwashing, the underreporting of environmental achievements, another form of corporate decoupling that is harmful for stakeholders. Using a sample of 5459 firm–year observations over the period 2007–2017, this study tests and finds that industry leaders brownwash their environmental performance to avoid peer pressure and excessive stakeholder attention, and to preserve their firm's leadership. Consequently, legitimate firms tend to converge toward informal industry standards that engender standardized environmental disclosures. Nevertheless, this phenomenon can be curbed by adopting sound environmental governance mechanisms aimed at improving corporate transparency and environmental practices.
The impact of employees' perceptions about top management engagement on sustainability development efforts and firm performance
Authors: Gopalakrishna‐Remani Venugopal , Byun Kyung‐Ah ( Kay) , Doty D. Harold 
Published: March 2022

AbstractBecause sustainability management plays a vital role in firm performance, it is critical to understand the underlying mechanisms that drive better firm performance with sustainability adoption. Thus, drawing upon responsible leadership theory and the dynamic resource‐based view, this study examines how the level of sustainability adoption influences firm performance, both environmental and financial, emphasizing the role of top management beliefs and participation in sustainability adoption. With responses from 310 employees working in manufacturing, healthcare, and retail industries, the SEM analysis results support that (i) perceived top management's strong beliefs lead to a higher level of sustainability adoption by organizations; (ii) perceived top management's active participation positively moderates the relationship between perceived top management beliefs and the level of sustainability adoption; (iii) the higher level of sustainability adoption results in better environmental and financial performance; and (iv) environmental performance positively and partially mediates the relationship between the level of sustainability adoption and financial firm performance. Finally, we offer guidance to managers who would like to leverage top management attributes to achieve environmental and financial performance via environmental sustainability practices.
Polyoxometalates Immobilized on Covalent Triazine Framework as Efficient Catalysts for Deep Oxidative Desulfurization
Authors: Liu Chengpeng , Li Zhen , Liu Huifang , Dong Jing , Chi Yingnan , Hu Changwen 
Published: March 2022

AbstractThe immobilized polyoxometalates (POMs) with evenly dispersed catalytic sites, amphiphilic surface, and excellent recyclability are highly desired in many important reactions. Herein, PMo12@CTF has been successfully fabricated by the electrostatic assembly of H3PMo12O40 (PMo12) with porous cationic covalent triazine framework (CTF), where PMo12 are evenly dispersed on the support. The synthesized PMo12@CTF is highly active for oxidative desulfurization of diesel fuel and dibenzothiophene (DBT) can be completely converted in 2 h under mild conditions (40 °C) in a biphasic system. Impressively, the catalytic activity of heterogeneous PMo12@CTF (conversion: 100 %) is much higher than that of homogeneous PMo12 (conversion: 20 %). The control experiments and contact angle measurements reveal that the CTF endows PMo12@CTF with large surface area and amphiphilic feature and the catalyst can effectively contact with both oxidant H2O2 in extraction phase and DBT in oil phase. Moreover, PMo12@CTF is robust and its catalytic activity is basically maintained after ten cycles.
A Photoresponsive Receptor with a 105 Magnitude of Reversible Anion‐Binding Switching
Authors: Einkauf Jeffrey D. , Bryantsev Vyacheslav S. , Moyer Bruce A. , Custelcean Radu 
Published: March 2022

AbstractIn a leap toward anion separation that uses only energy input for binding and release cycles, we report herein a new class of photoswitchable anion receptors featuring a diiminoguanidinium functionality that displays a change of more than five orders of magnitude in switched‐off binding strength towards sulfate, a representative oxyanion, upon photoirradiation with UV light. The (E,E)‐2‐pyridyl‐diiminoguanidinium cation, synthesized as the triflate salt, binds sulfate with extraordinary strength in [D6]DMSO owing to its bidentate guanidinium hydrogen bonding, which can chelate the O−S−O edge of sulfate. Upon photoisomerization to the Z,Z isomer, the anion‐binding site is essentially shut off by intramolecular hydrogen bonds to the 2‐pyridyl substituents, as shown by anion‐binding titrations, theoretical calculations, and X‐ray structural analysis. This approach will allow the development of advanced anion‐separation cycles that use only energy input and generate no chemical waste, and thus address challenging chemical separation problems in a more sustainable way.
Controlling the Dual‐Emission Character of Aryl‐Modified o‐Carboranes by Intramolecular CH⋅⋅⋅O Interaction Sites
Authors: Ochi Junki , Yuhara Kazuhiro , Tanaka Kazuo , Chujo Yoshiki 
Published: March 2022

AbstractInvited for the cover of this issue is the group of Kazuo Tanaka at Kyoto University. The image depicts the control of solid‐state dual‐emissive properties by modulating the intramolecular hydrogen bonding in boron clusters. Read the full text of the article at 10.1002/chem.202200155.