bluuebunny/crossref_metadata_2025_split huggingface dataset:
DIGITAL SIGNAGE : MAKNA, STRATEGI PEMBUATAN PESAN, DAN IMPLEMENTASI OLEH DENTSU AGENCY
Authors: Ningrum Karina Pramita 
Published: June 2022

AbstractThis article discusses the digital signage: meaning, message creating strategy and implementation by Dentsu Agency. The success of an advertising message in capturing the audience's attention and create awareness of one set of capabilities includes an advertising content in the audio and visual elements of the use of the media, this study aims to determine the stage of making understand the message of the use of digital signage medium that has limitations on audio elements that able to highlight the visual elements that still give th eaudience an understanding in accordance with the audio function. This study used a qualitative research method with descriptive explorative design, to explain the results of the interview and observation data analysis techniques used thematic analysis. The results showed limitations in representing by the agency of visual elements on the digital signage medium in capturing the attention of the audience, persuasive, and increase awareness of the audience for a productor service through the medium. Production strategies under taken message includes three stages which includes the step of: 1) Pre-production, 2) production, and 3) Post- Production. Implementation of the medium is seen in the field of advertising (commercial) and some other fields related to the use of digital signage. Keywords:Digital Signage,Implementation of Digital Signage,Message Creating Strategy. AbstrakPenelitian ini membahas tentang digital signage: makna, strategi pembuatan pesan dan implementasi oleh Dentsu Agency. Keberhasilan sebuah pesan iklan dalam menangkap atensi dan menciptakan awareness audiens salah satunya ditentukan dari kemampuan sebuah konten iklan dalam menonjolkan unsur audio dan visual dari penggunaan media, penelitian ini bertujuan untuk mengetahui memahami tahapan pembuatan pesan dari penggunaan medium digital signage yang memiliki keterbatasan pada unsur audio agar mampu menonjolkan unsur visual yang tetap memberikan pemahaman pada audiens sesuai dengan fungsi audio. Penelitian ini menggunakan metode penelitian kualitatif dengan desain deskriptif ekploratif, untuk menjelaskan hasil wawancara dan observasi digunakan teknik analisis data dengan analisa tematik. Hasil penelitian menunjukkan keterbatasan agency dalam menunjukan unsur visual pada medium digital signage dalam menangkap atensi dari audiens, persuasif, dan meningkatkan awareness audiens terhadap sebuah produk atau jasa melalui medium tersebut. Strategi produksi pesan yang dilakukan meliputi tiga tahapan yang meliputi tahap : 1) Pra produksi, 2) Produksi, dan 3) Pasca Produksi. Implementasi penggunaan medium ini dilihat dalam bidang periklanan (komersial) dan beberapa bidang lainnya yang berkaitan dengan penggunaan digital signage. Kata kunci : Digital Signage,Implementasi,Strategi Pembuatan Pesan.
WAYANG BEBER FABEL SEBAGAI MEDIA STORYTELLING UNTUK ANAK USIA DINI
Authors: Noegroho Jati 
Published: June 2022

Abstract Wayang Beber is media education for kids. Before enter to Kindergarteen School. The kids are need instrument media for easly education process. Writer has give a solution , for creating Wayang Beber design . Wayang Beber design take a fabel story. Fabel story a duck was face to face with the predator or eagle. The story have message morality about “feel regard for parents must to fertilize from beginning”. The goals is help teacher for description or folklore for PAUD Student. For help educator for suitable, intereresting, and easily in give education with Wayang Beber Fabel. Keywords : Wayang Beber, teacher visuallitation, variaty in education Abstrak Wayang Beber sebagai media pembelajaran untuk anak-anak Anak Usia Dini (selanjutya disebut PAUD). Sebelum memasuki sekolah Taman kanak-kanak(selanjutnya disebut TK). Anak anak PAUD memerlukan alat atau media peraga untuk mempermudah dalam menyerap proses belajar. Penulis menawarkan sebuah solusi untuk membuat desain Wayang untuk anak-anak PAUD. Desain wayang PAUD mengambil cerita kisah Fabel atau cerita tentang binatang. Cerita tentang binatang unggas (bebek) berhadapan dengan pemangsa atau elang (Predator). Ada pesan moral di dalam ceritanya berupa “Rasa hormat kepada orangtua yang harus dipupuk sedini mungkin” .Tujuan utamanya adalah membantu visualisai guru untuk menerangkan atau mendongeng untuk murid-murid PAUD . Membantu para pendidik untuk pelengkap dan sebagai media pembelajaran lain. Media pembelajaran yang menarik dan atraktif dengan sebuah totonan Wayang Beber Fabel. Pertunjukan Wayang Beber Fabel dapat dijadikan alternatif untuk mengajar bagi guru pendidik di lingkungan PAUD. Agar lebih variatif dalam mengajar. Kata kunci : Wayang Beber, variatif dalam mengajar, visualisai guru
Meningkatkan Jiwa Leadership Siswa SMA Muhammadiyah 8 Ciputat dalam Manajemen Perencanaan Berwirausaha
Authors: Susilo Wardani Endang , Iqbal Khair Oki , Octovian Reza , Riana Harjayanti Diana , Tanius Nelwati 
Published: June 2022

The main problem, which is commonly faced is the concerns in running an entrepreneur and the lack of leadership spirit that grows in the student environment. We try to motivate and provide counseling that the spirit of leadership needs to be grown and nurtured early on, especially in entrepreneurship. Let us not be afraid to start but seize the opportunities that exist accompanied by strong intentions. Strong desire can be the driving force of our start in entrepreneurship Is expected by providing counseling to improve the Spirit of Leadership of Muhammadiyah 8 High School students. Ciputat in the management of entrepreneurship planning can foster the spirit of leadership as well as this becomes the expected external with the implementation of this PkM.
Factors affecting perioperative patient satisfaction with regional anesthesia: A patient-centered survey study
Authors: BORAN Ömer Faruk , GÜNAY Osman , GÜNAY Ali Eray , BORAN Maruf , BİLAL Bora , BAKACAK Murat , YAZAR Fatih Mehmet , DOLU Hasan , BOZAN Mehmet Bugra , BİRADLİ Hilal 
Published: June 2022

Objective: To determine the demographic and clinical characteristics that affect patient satisfaction with regional anesthesia.
Methods: This study was conducted at Kahramanmaras Sutcu Imam University Hospital between June-July 2019. The patients were included on a voluntary basis and all had undergone obstetrics, urology, orthopedics, or general surgery, and met the following inclusion criteria: (1) age >18 years, (2) received regional anesthesia, (3) ASA-PS score of ≤ 3, and (4) no cognitive problem that would prevent self-expression. A Personal Information Form and the Evaluation of the Experience of Regional Anesthesia Questionnaire were applied to 402 patients at 48 hours after surgery performed under regional anesthesia in a university hospital in Turkey.
Results: The EVAN-LR total scores were 71.2±15.6 in obstetrics patients, followed by 54.9±24.9 in orthopedic patients, 26.6±24.4 in urology patients and 15.9±7.2 in general surgery patients (p
Cytokine Concentrations in Aqueous Humor of Eyes With Circumscribed Choroidal Hemangioma
Authors: Liu Kailin , Guo Lili , Cheng Yong , Liang Jianhong 
Published: June 2022

PurposeAnti-vascular endothelial growth factor (anti-VEGF) treatment are now widely used in patients with circumscribed choroidal hemangioma (CCH), however the concentrations of VEGF and other cytokines in CCH patients have not been known before. The study was conducted to compare various cytokine concentrations in the aqueous humor of eyes with CCH and control.MethodsA total of 16 eyes of 16 patients with CCH, and 15 eyes of 15 patients with cataract as the control group were examined. Aqueous humor samples were assessed for 30 angiogenic and inflammatory cytokines by Luminex bead-based multiplex array.ResultsSignificantly, compared with control group, higher concentrations of VEGF-A and IP-10 were found in the CCH patients (P = 0.002 and P &lt; 0.001).ConclusionsVEGF-A and IP-10 might be involved with the angiogenic and antiangiogenic process in CCH patients, which provides new insight into the pathophysiology of CCH and could be potential targets for treatment.
Predicting Progression, Recurrence, and Survival in Pancreatic Neuroendocrine Tumors: A Single Center Analysis of 174 Patients
Authors: Krogh Sara , Grønbæk Henning , Knudsen Anders Riegels , Kissmeyer-Nielsen Peter , Hummelshøj Nynne Emilie , Dam Gitte 
Published: June 2022

IntroductionThe European Neuroendocrine Tumor Society, ENETS, reports variables of prognostic significance in pancreatic neuroendocrine tumors (PNET). However, studies have short follow-ups, and the optimal treatment remains controversial. We aimed to determine overall survival (OS), progression-free survival (PFS) after conservative treatment, and recurrence-free survival (RFS) after surgery and further to find predictors of aggressive PNET behavior to support treatment decisions.Methods174 patients with PNET treated at Aarhus University Hospital from 2011 to 2021 were included in a retrospective cohort study. Patients were divided into surgically resected (SUR, n=91) and medically or conservatively treated (MED, n=83). Variables were tested in univariate and multivariate survival analysis. Median follow-up time was 3.4 years in the MED group and 4.5 years in the SUR group.ResultsThe 5-year OS was 95% and 65% for the SUR and MED groups, respectively. The 5-year RFS in the SUR group was 80% whereas the 5-year PFS in the MED group was 41%. Larger tumor size, Ki67 index, tumor grade, and stage were predictive of shorter OS, RFS, and PFS. Further, chromogranin A was a predictor of OS. Larger tumor size was associated with higher stage and grade. Only 1 of 28 patients with stage 1 disease and size ≤2 cm developed progression on a watch-and-wait strategy during a median follow-up of 36 months.ConclusionThis study supported the ENETS staging and grading system to be useful to predict OS, PFS, and RFS in PNET. Further, our data support that small, localized, low-grade PNETS can be followed with active surveillance.
Genetics of Inherited Retinal Diseases in Understudied Ethnic Groups in Italian Hospitals
Authors: Maltese Paolo Enrico , Colombo Leonardo , Martella Salvatore , Rossetti Luca , El Shamieh Said , Sinibaldi Lorenzo , Passarelli Chiara , Coppè Andrea Maria , Buzzonetti Luca , Falsini Benedetto , Chiurazzi Pietro , Placidi Giorgio , Tanzi Benedetta , Bertelli Matteo , Iarossi Giancarlo 
Published: June 2022

Purpose: Describing the clinical and genetic features of an ethnically heterogeneous group of (inherited retinal diseases) IRD patients from different underrepresented countries, referring to specialized Italian Hospitals, and expanding the epidemiological spectrum of the IRD in understudied populations.Methods: The patients’ phenotypes underwent were characterized by exhaustive ophthalmological examinations, including morpho-functional testing. Genetic testing was performed using next-generation sequencing (NGS) and gene sequencing panels targeting a specific set of genes, Sanger sequencing and—when necessary—multiplex ligation-dependent probe amplification (MLPA) to better identify the genotype. When possible, segregation analysis was performed in order to confirm unsolved cases.Results: The article reports the results of the phenotypes and genotypes of 123 IRD probands, 69 males and 54 females, mean age 41 (IQR, 54–30) years, disease onset at 13 (IQR, 27.25–5) years. Thirty-three patients out of 123 (26.8%) were Africans (North/Northwest Africa), 21 (17.1%) Asians, 19 (15.4%) Americans (South/Central America) and 50 (40.7%) Europeans (Eastern Europe). Retinitis pigmentosa was the most represented phenotype (56%), followed by cone dystrophy (11%) and Leber congenital amaurosis (7%), while ABCA4 was the most frequently mutated gene (18%), followed by USH2A (9%) and RPGR (5%). About ABCA4 variants found in Stargardt disease, macular and cone dystrophies were predominant in Asian (42%) and European (21%) patients. The most represented inheritance pattern was autosomal recessive, while a higher frequency of homozygous patients versus compound heterozygotes as compared to previous studies on Italian IRD patients was evidenced, reflecting a possible higher frequency of inbreeding marriages.Conclusion: Though limited by the relatively low number of patients, the present paper paints a picture of the clinical and genetic features of IRD patients from understudied ethnic groups referred to Italian specialized hospitals and extended the epidemiological studies on underrepresented world regional areas.
Probiotics Surface-Delivering Fiber2 Protein of Fowl Adenovirus 4 Stimulate Protective Immunity Against Hepatitis-Hydropericardium Syndrome in Chickens
Authors: Jia Zhipeng , Pan Xinghui , Zhi Wenjing , Chen Hang , Bai Bingrong , Ma Chunli , Ma Dexing 
Published: June 2022

Background and ObjectivesHepatitis-hydropericardium syndrome (HHS) caused by Fowl adenoviruses serotype 4 (FAdV-4) leads to severe economic losses to the poultry industry. Although various vaccines are available, vaccines that effectively stimulate intestinal mucosal immunity are still deficient. In the present study, novel probiotics that surface-deliver Fiber2 protein, the major virulence determiner and efficient immunogen for FAdV-4, were explored to prevent this fecal–oral-transmitted virus, and the induced protective immunity was evaluated after oral immunization.MethodsThe probiotic Enterococcus faecalis strain MDXEF-1 and Lactococcus lactis NZ9000 were used as host strains to deliver surface-anchoring Fiber2 protein of FAdV-4. Then the constructed live recombinant bacteria were orally vaccinated thrice with chickens at intervals of 2 weeks. Following each immunization, immunoglobulin G (IgG) in sera, secretory immunoglobulin A (sIgA) in jejunum lavage, immune-related cytokines, and T-cell proliferation were detected. Following challenge with the highly virulent FAdV-4, the protective effects of the probiotics surface-delivering Fiber2 protein were evaluated by verifying inflammatory factors, viral load, liver function, and survival rate.ResultsThe results demonstrated that probiotics surface-delivering Fiber2 protein stimulated humoral and intestinal mucosal immune responses in chickens, shown by high levels of sIgA and IgG antibodies, substantial rise in mRNA levels of cytokines, increased proliferative ability of T cells in peripheral blood, improved liver function, and reduced viral load in liver. Accordingly, adequate protection against homologous challenges and a significant increase in the overall survival rate were observed. Notably, chickens orally immunized with E. faecalis/DCpep-Fiber2-CWA were completely protected from the FAdV-4 challenge, which is better than L. lactis/DCpep-Fiber2-CWA.ConclusionThe recombinant probiotics surface-expressing Fiber2 protein could evoke remarkable humoral and cellular immune responses, relieve injury, and functionally damage target organs. The current study indicates a promising method used for preventing FAdV-4 infection in chickens.
Postoperative Cognitive Dysfunction and Alzheimer’s Disease: A Transcriptome-Based Comparison of Animal Models
Authors: Wang Yi-Wei , Wang Liang , Yuan Sheng-Jie , Zhang Yuan , Zhang Xin , Zhou Le-Ting 
Published: June 2022

BackgroundPostoperative cognitive dysfunction (POCD) is a common complication characterized by a significant cognitive decline. Increasing evidence suggests an association between the pathogenesis of POCD and Alzheimer’s disease (AD). However, a comprehensive understanding of their relationships is still lacking.MethodsFirst, related databases were obtained from GEO, ArrayExpress, CNGB, and DDBJ repositories. De novo analysis was performed on the raw data using a uniform bioinformatics workflow. Then, macro- and micro-level comparisons were conducted between the transcriptomic changes associated with AD and POCD. Lastly, POCD was induced in male C57BL/6j mice and the hippocampal expression levels of mRNAs of interest were verified by PCR and compared to those in AD congenic models.ResultsThere was a very weak correlation in the fold-changes in protein-coding transcripts between AD and POCD. Overall pathway-level comparison suggested that AD and POCD are two disease entities. Consistently, in the classical AD pathway, the mitochondrial complex and tubulin mRNAs were downregulated in both the POCD hippocampus and cortex. POCD and AD hippocampi might share the same pathways, such as tryptophan metabolism, but undergo different pathological changes in phagosome and transferrin endocytosis pathways. The core cluster in the hippocampal network was mainly enriched in mitosis-related pathways. The hippocampal expression levels of genes of interest detected by PCR showed good consistency with those generated by high throughput platforms.ConclusionPOCD and AD are associated with different transcriptomic changes despite their similar clinical manifestations. This study provides a valuable resource for identifying biomarkers and therapeutic targets for POCD.
The Degree Centrality and Functional Connectivity in Patients With Temporal Lobe Epilepsy Presenting as Ictal Panic: A Resting State fMRI Study
Authors: Chang Weiwei , Liu Jinping , Nie Liluo , Pang Xiaomin , Lv Zongxia , Zheng Jinou 
Published: June 2022

ObjectivesIctal panic (IP) can be observed occasionally in patients with temporal lobe epilepsy (TLE). Such descriptions can be found in previous studies, but the mechanism is still not clear and often confused with panic attacks in patients with panic disorder (PD). We try to use imaging methods (resting-state functional magnetic resonance imaging, rs-fMRI) to study the mechanism of this psychiatric comorbidity in patients with TLE.MethodsForty right-onset TLE patients were observed, including 28 patients with TLE but without IP and 12 patients with TLEIP along with 30 gender-age matched healthy controls were included. We collected clinical/physiological/neuropsychological and rs-fMRI data. Degree centrality (DC) and functional connectivity (FC) were calculated. For the DC and FC values, analysis of covariance (ANCOVA) was used to find different areas and t-tests were used to compare differences between the TLEIP, TLE without IP, and healthy control(HC)groups. The relationship between brain abnormalities and patient characteristics was explored by correlation analyses.ResultsNo significant differences in gender and age were found among the three groups, and no significant differences in education level, Montreal Cognitive Assessment (MOCA), Hamilton Depressive Scale (HAMD), Hamilton Anxiety Scale (HAMA), and epilepsy duration (years) between the TLEIP and TLE without IP groups. In addition to fear, other symptoms were observed, including nausea, palpitations, rising epigastric sensation, and dyspnea. There was no correlation between the duration of IP and HAMA. Moreover, all IP durations were &lt;2 min. Compared to the HCs and TLE without IP group, the DC value of the TLEIP group in the left middle temporal gyrus (LMTG) was significantly increased. Compared to the HCs, FC could be found between the LMTG and left inferior temporal gyrus (LITG) in the TLEIP group. In addition, there was FC between the LMTG and cerebellum in the TLEIP group. The difference in the magnitude of FC between the TLEIP vs. HC group was greater than the difference between the TLE vs. HC group.ConclusionsThis study describes brain abnormalities in patients with TLEIP. These results will help to preliminarily understand the mechanism of ictal panic and abnormal functional connection in patients with TLE, and further explore the neuroimaging mechanism of ictal panic in patients with TLE.
Development of a Score to Predict the Paroxysmal Atrial Fibrillation in Stroke Patients: The Screening for Atrial Fibrillation Scale
Authors: Amaya Pascasio Laura , Quesada López Miguel , García-Torrecillas Juan Manuel , Arjona-Padillo Antonio , Martínez Sánchez Patricia 
Published: June 2022

Background and PurposeAn individual selection of ischemic stroke patients at higher risk of atrial fibrillation (AF) might increase the diagnostic yield of prolonged cardiac monitoring and render it cost-effective.MethodsThe clinical, laboratory, and brain/cardiac imaging characteristics of consecutive ischemic stroke patients without documented AF were recorded. All patients underwent at least 72 h of cardiac monitoring unless AF was diagnosed before, transthoracic echocardiogram, blood biomarkers, and intracranial vessels imaging. A predictive grading was developed by logistic regression analysis, the screening for atrial fibrillation scale (SAFE).ResultsA total of 460 stroke patients were analyzed to develop the SAFE scale, a 7-items score (possible total score 0–10): age ≥ 65 years (2 points); history of chronic obstructive pulmonary disease or obstructive sleep apnea (1 point); thyroid disease (1 point); NT-proBNP ≥ 250 pg/ml (2 points); left atrial enlargement (2 points); cortical topography of stroke, including hemispheric or cerebellar cortex (1 point); and intracranial large vessel occlusion (1 point). A score = 5 identified patients with paroxysmal AF with a sensitivity of 83% and a specificity of 80%.ConclusionScreening for atrial fibrillation scale (SAFE) is a novel and simple strategy for selecting ischemic stroke patients at higher risk of having AF who can benefit from a more thorough etiological evaluation. External validation of SAFE in a multicenter study, with a larger number of patients, is warranted.
Contributory Factors for Teen Insomnia Symptoms: A Prospective Cohort Study in Sweden
Authors: Hedin Gita , Norell-Clarke Annika , Tønnesen Hanne , Westergren Albert , Garmy Pernilla 
Published: June 2022

ObjectivesInsufficient sleep is a public health problem that impacts the mental and physical health of children and adolescents. Complaints of insomnia are particularly pervasive among adolescents. This longitudinal study investigates factors that contribute to teen insomnia symptoms.DesignFive-year prospective follow-up study.SettingSchool-based.ParticipantsA total of 522 children (49.8% girls) aged 9.4 ± 1.3 years at baseline; 14.4 ± 0.7 years at follow-up.MeasurementsThe dependent variable of insomnia symptoms at follow-up was assessed with the Minimal Insomnia Symptom Scale-Revised. The independent variables at baseline were the perceived family financial situation, tiredness at school, problems waking up, short sleep duration, sleeping difficulties, having a bedroom Television (TV), and time spent with a TV/computer. Multivariate binary logistic regression analyses were used to examine whether the independent variables at baseline predicted insomnia symptoms at follow-up.ResultsPerceived quite bad/very bad family financial situation (OR 3.1; CI 1.4–6.7) and short sleep duration (&lt;10 h) (OR 2.3; CI 1.0–5.3) among girls at baseline were associated with insomnia symptoms at follow-up. Having problems waking up among boys at baseline was associated with insomnia symptoms at follow-up (OR 4.9; CI 1.6–14.4).ConclusionShort sleep duration, problems waking up, and perceived bad family financial situation during childhood were linked with adolescent insomnia symptoms. The sex-based differences in these associations warrant further investigation to effectively mitigate adolescent insomnia.