bluuebunny/crossref_metadata_2025_split huggingface dataset:
RANCANG BANGUN SISTEM INFORMASI KELEMBAGAAN PETANI BERBASIS WEB STUDI KASUS JAWA BARAT
Authors: Fikri Ramadhon  , Fajar Kusumah Fitrah Satyra , Fajri Hersanto 
Published: August 2022

Akses informasi terhadap kelembagaan petani di Indonesia belum merata dan sulit untuk didapatkan. Padahal peran sektor pertanian sangat besar bagi pertumbuhan ekonomi nasional. Oleh sebab itu diperlukan suatu solusi agar memudahkan semua kalangan untuk mendapatkan akses informasi yang baik terhadap kelembagaan petani. Maka dari itu tujuan dari penelitian ini adalah membangun Sistem Informasi berbasis Web yang mampu memonitoring data kelembagaan petani seperti Kelompok Tani (POKTAN) dan Gabungan Kelompok Tani (GAPOKTAN).
Data yang digunakan dalam pembuatan sistem informasi kelembagaan petani terdiri dari 124 Kelompok Tani, 44 Gabungan Kelompok Tani, dan 6973 Petani. Penelitian ini berhasil menyajikan sebaran lokasi kelembagaan petani dan informasi mengenai data kelembagan petani seperti anggota, potensi komoditas, luas lahan, dan fasilitas di wilayah Jawa Barat berbasis Web untuk berbagai kalangan baik itu pemerintah maupun non pemerintah. Selain itu sistem informasi kelembagaan petani juga dapat menjadi refrensi untuk pemerintah dalam memberikan bantuan kepada para petani melalui perantara kelembagaan petani.
Metode pembuatan sistem menggunakan model waterfall terdiri dari analisis kebutuhan, desain sistem, pengkodean, dan pengujian. Sedangkan desainnya menggunakan paradigma object oriented dengan UML. Bahasa pemrograman yang digunakan adalah PHP dan MySql sebagai databasenya.
Oral antibiotics perturbation on gut microbiota after prostate biopsy
Authors: Li Joseph Kai Man , Wang Lynn Lin , Lau Becky Su Yan , Tse Ryan Tsz Hei , Cheng Carol Ka Lo , Leung Steven Chi Ho , Wong Christine Yim Ping , Tsui Stephen Kwok Wing , Teoh Jeremy Yuen Chun , Chiu Peter Ka Fung , Ng Chi Fai 
Published: August 2022

IntroductionThe use of antibiotics may induce the changes in gut microbiota. Previous studies have shown conflicting results on whether the changed gut microbiota by antibiotics can be recovered. Our study aims to investigate whether the gut microbiota could be recovered after a single dose of oral co-amoxiclav before transrectal ultrasound-guided transperineal prostate biopsy (TPPBx) in 5 weeks’ time.MethodsFifteen patients with elevated serum prostate-specific antigen (PSA) were recruited to provide pre-antibiotic and post-antibiotic fecal samples. The V4 region of 16S rRNA was sequenced. Analysis was performed by QIIME2. Alpha- and beta-diversities were analyzed, as well as the differential enrichment by Linear discriminant analysis Effect Size (LEfSe) analysis.ResultsBoth the alpha- and beta-diversities of the pre- and post-antibiotic fecal samples were significantly different. Genera that are associated with alleviation of inflammation were enriched in the pre-antibiotic fecal samples, while the inflammation-associated genera were more enriched in the post-antibiotic fecal samples.ConclusionA single dose of oral co-amoxiclav before TPPBx could have led to a change of gut microbiota that cannot be recovered in 5 weeks' time. Microbiome studies on prostate cancer patients should be cautioned on the use of post-prostate biopsy fecal sampling. Further studies should be conducted for the impact on gut microbiome for TPPBx alone.
Motoric cognitive risk syndrome and incident hospitalization in Quebec's older population: Results of the NuAge cohort study
Authors: Beauchet Olivier , Matskiv Jacqueline , Launay Cyrille P. , Gaudreau Pierrette , Allali Gilles 
Published: August 2022

BackgroundScreening older adults at risk of hospitalization is essential to prevention of this adverse event. Motoric cognitive risk syndrome (MCR) has been associated with incident dementia and falls, which are both risk factors of hospitalization. There is no information on the association of MCR with incident hospitalization in older adults.ObjectiveThe study aims to examine the association of MCR with incident hospitalization in community-dwelling older adults.DesignQuebec older population-based observational cohort study with 3 years of follow-up.SettingCommunity dwellings.SubjectsA subset of 999 participants recruited in the NuAge study.MethodsParticipants with MCR (i.e., with slow gait and cognitive complaint without dementia or motor disability) were identified at baseline assessment. Incident hospitalization (i.e., ≥1) and its recurrence (i.e., ≥2) were collected annually over a 3 year follow-up period.ResultsThe prevalence of MCR was 5.0% at baseline. The overall incidence of hospitalization was 29.0% and its recurrence 4.8%. MCR was associated with incident recurrent hospitalization [adjusted Hazard Ratio (aHR) = 2.58 with 95% Confidence Interval (CI) = (1.09–6.09) and P = 0.031], but not with incident hospitalization [aHR = 1.48, with 95%CI = (0.95–2.28) and P = 0.081].ConclusionMCR is associated with incident recurrent hospitalization in NuAge participants, suggesting that MCR may be of clinical interest for screening individuals at risk for hospitalization in Quebec's older population.
Acupuncture modulates the frequency-specific functional connectivity density in primary dysmenorrhea
Authors: Liu Li-Ying , Li Xiang , Tian Zi-Lei , Zhang Qi , Shen Zhi-Fu , Wei Wei , Guo Xiao-Li , Chen Ling , Su Meng-Hua , Yang Lu , Yu Si-Yi , Yang Jie 
Published: August 2022

BackgroundThe study aimed to investigate how acupuncture modulates brain activities across multiple frequency bands to achieve therapeutic effects in PDM.MethodsA total of 47 patients with PDM were randomly assigned to the verum acupuncture group and sham acupuncture group with three menstrual cycles of the acupuncture course. The fMRI scans, visual analog scale (VAS) scores, and other clinical evaluations were assessed at baseline and after three menstrual-cycles treatments. The global functional connectivity density (gFCD) analyses were performed between the pre-and post-acupuncture course of two groups at full-low frequency band, Slow-3 band, Slow-4 band, and Slow-5 band.ResultsAfter the acupuncture treatments, the patients with PDM in the verum acupuncture group showed significantly decreased VAS scores (p &lt; 0.05). The frequency-dependent gFCD alternations were found in the verum acupuncture group, altered regions including DLPFC, somatosensory cortex, anterior cingulate cortex (ACC), middle cingulate cortex (MCC), precuneus, hippocampus, and insula. The sham acupuncture modulated regions including angular gyrus, inferior frontal gyrus, and hippocampus. The gFCD alternation in DLPFC at the Slow-5 band was negatively in the patients with PDM following verum acupuncture, and S2 at the Slow-4 band was positively correlated with VAS scores.ConclusionThese findings supported that verum acupuncture could effectively modulate frequency-dependent gFCD in PDM by influencing abnormal DLPFC at Slow-5 band and hippocampus at the Slow-3 band. The outcome of this study may shed light on enhancing the potency of acupuncture in clinical practice.
Preoperative Naples prognostic score is a reliable prognostic indicator for newly diagnosed glioblastoma patients
Authors: Li Junhong , Yang Wanchun , Yuan Yunbo , Zuo Mingrong , Li Tengfei , Wang Zhihao , Liu Yanhui 
Published: August 2022

BackgroundGlioblastoma (GBM) accounts for approximately 80% of malignant gliomas and is characterized by considerable cellularity and mitotic activity, vascular proliferation, and necrosis. Naples prognostic score (NPS), based on inflammatory markers and nutritional status, has a prognostic ability in various cancers. In the current study, we aim to explore the prognostic value of operative NPS in GBM patients and compare the prognostic ability between NPS and controlling nutritional status (CONUT).Materials and methodsThe retrospective analysis was carried out on consecutive newly diagnosed GBM patients who had underwent tumor resection at West China Hospital from February 2016 to March 2019. All statistical analyses were conducted using SPSS software and R software.ResultsA total of 276 newly diagnosed GBM patients were enrolled in the current study. Overall survival (OS) (p &lt; 0.001) and tumor location (p = 0.007) were significantly related to NPS. Serum albumin concentrate, cholesterol concentrate, neutrophil-to-lymphocyte ratio, lymphocyte ratio, and CONUT score were all significantly associated with NPS (p &lt; 0.001). The Kaplan–Meier curve indicated that NPS (log-rank test, p &lt; 0.001) and CONUT score (log-rank test, p = 0.023) were significantly associated with OS. Multivariate Cox regression revealed that both NPS and CONUT score served as independent prognostic indicators. The prognostic model with NPS had the strongest prognostic capability and best model-fitting.ConclusionIn the current study, NPS is found as an independent prognostic indicator for patients with newly diagnosed GBM, and the prognostic ability of NPS is superior to CONUT score.
One-year recovery from breast cancer: Importance of tumor and treatment-related factors, resilience, and sociodemographic factors for health-related quality of life
Authors: Veličković Katarina , Borrebaeck Carl A. K. , Bendahl Pär-Ola , Hegardt Cecilia , Johnsson Per , Richter Corinna , Rydén Lisa , Hallberg Ingalill Rahm 
Published: August 2022

AimThis study investigated the changes in health-related quality of life from diagnosis to 1 year after diagnosis in breast cancer (BC) patients and the influence of clinical, psychological, and sociodemographic variables. An additional aim was to explore the mediating and moderating effects of resilience on changes in health-related quality of life.MethodsA longitudinal population-based study was conducted in southern Sweden. Newly diagnosed BC patients filled in measures of health-related quality of life, resilience, and sociodemographic variables at diagnosis (N = 980) and 1 year post-diagnosis (N = 780). Clinical variables were extracted from the Swedish national breast cancer quality registry. Mixed-model analyses were performed.ResultsMost health-related quality of life outcomes declined from diagnosis to 1 year post-diagnosis. Role limitations due to emotional problems remained the same, whereas mental health improved. Lower health-related quality of life outcomes were associated with symptomatic detection and axillary dissection. Patients with a higher TNM stage and histologic grade and estrogen receptor (ER)-negative and human epidermal growth factor 2 (HER2)-positive status, who received chemotherapy, antibody therapy, or bisphosphonate therapy, had a steeper decline in outcomes. Changes in resilience were positively associated with all outcomes but did not mediate or moderate changes in any. Resilience at baseline moderated changes in bodily pain, vitality, and mental health, with higher baseline resilience being associated with a steeper decline, possibly due to floor or ceiling effects. Patients with lower socioeconomic status, educational level, and older age had a lower health-related quality of life.ConclusionPhysical health-related quality of life among breast cancer patients declined 1 year post-diagnosis, whereas mental health-related quality of life improved. Low resilient patients may be especially vulnerable at diagnosis. Biopsychosocial assessment at diagnosis can help identify patients who may require additional support. A multidimensional treatment plan should be started early to help overcome the problems in everyday activities.
Efficacy of immune checkpoint inhibitors in non-small cell lung cancer: A systematic review and meta-analysis
Authors: Yang Fang , Wang Yucai , Tang Lin , Mansfield Aaron Scott , Adjei Alex A. , Leventakos Konstantinos , Duma Narjust , Wei Jia , Wang Lifeng , Liu Baorui , Molina Julian R. 
Published: August 2022

BackgroundImmune checkpoint inhibitors (ICIs) have demonstrated remarkable efficacy in non-small cell lung cancer (NSCLC). However, only a minority of NSCLC patients benefit from ICIs, and whether the magnitude of benefit is specific factor-dependent remains unclear. We performed a systematic review to improve our understanding of clinicopathologic and biomolecular features associated with improved survival upon treatment with ICIs for NSCLC.MethodsWe searched PubMed, Web of Science, Embase, and Scopus from database inception to August 31, 2021, for randomized controlled trials (RCTs) comparing overall survival (OS) in NSCLC treated with ICIs vs control therapies. We calculated the pooled OS hazard ratio (HR) and 95% CI in subgroups using a random-effects model, and assessed the heterogeneity between the paired estimates using an interaction test.ResultsA total of 23 RCTs involving 15,829 patients were included. We found that wild-type EGFR, high PD-L1 expression, and high bTMB were associated with a significant OS benefit from ICIs, but not mutant EGFR, low PD-L1 expression, and low bTMB. The differences of OS benefit between wild-type and mutant EGFR (HR=1.53, 95%CI 1.13-2.08), high and low PD-L1 (HR=1.35; 95%CI 1.14-1.61), high and low bTMB (HR=1.71; 95%CI 1.17-2.52) were statistically significant. OS benefit was found in all subgroups regardless of sex, age, ECOG PS, histology, smoking history, baseline brain metastasis, race, and region, and the interaction test demonstrated no significant difference of the OS benefit between these opposed subgroups (e.g. male vs female).ConclusionsWild-type EGFR, high PD-L1 expression, and high bTMB are associated with a greater magnitude of efficacy from ICIs vs control therapies in NSCLC. However, the administration of ICIs should not be restricted to other clinicopathological factors (sex, smoking history, race, etc.).
Malignancy risk of gastrointestinal stromal tumors evaluated with noninvasive radiomics: A multi-center study
Authors: Wang Yun , Wang Yurui , Ren Jialiang , Jia Linyi , Ma Luyao , Yin Xiaoping , Yang Fei , Gao Bu-Lang 
Published: August 2022

PurposeThis study was to investigate the diagnostic efficacy of radiomics models based on the enhanced CT images in differentiating the malignant risk of gastrointestinal stromal tumors (GIST) in comparison with the clinical indicators model and traditional CT diagnostic criteria.Materials and methodsA total of 342 patients with GISTs confirmed histopathologically were enrolled from five medical centers. Data of patients wrom two centers comprised the training group (n=196), and data from the remaining three centers constituted the validation group (n=146). After CT image segmentation and feature extraction and selection, the arterial phase model and venous phase model were established. The maximum diameter of the tumor and internal necrosis were used to establish a clinical indicators model. The traditional CT diagnostic criteria were established for the classification of malignant potential of tumor. The performance of the four models was assessed using the receiver operating characteristics curve.ReusltsIn the training group, the area under the curves(AUCs) of the arterial phase model, venous phase model, clinical indicators model, and traditional CT diagnostic criteria were 0.930 [95% confidence interval (CI): 0.895-0.965), 0.933 (95%CI 0.898-0.967), 0.917 (95%CI 0.872-0.961) and 0.782 (95%CI 0.717-0.848), respectively. In the validation group, the AUCs of the models were 0.960 (95%CI 0.930-0.990), 0.961 (95% CI 0.930-0.992), 0.922 (95%CI 0.884-0.960) and 0.768 (95%CI 0.692-0.844), respectively. No significant difference was detected in the AUC between the arterial phase model, venous phase model, and clinical indicators model by the DeLong test, whereas a significant difference was observed between the traditional CT diagnostic criteria and the other three models.ConclusionThe radiomics model using the morphological features of GISTs play a significant role in tumor risk stratification and can provide a reference for clinical diagnosis and treatment plan.
Real-world effectiveness of Yindan Jiedu granules-based treatment on patients infected with the SARS-CoV-2 Omicron variants BA.2 combined with high-risk factors: A cohort study
Authors: Feng Ying , Liu Yao , Liu Long , Liu Yao , Jiang Yuyong , Hou Yixin , Zhou Yang , Song Rui , Chen Xiaoyou , Wang Xianbo 
Published: August 2022

Background: Our previous studies have shown that Yindan Jiedu granules (YDJDG) can effectively treat coronavirus disease 2019 (COVID-19); however, the high infectivity and the immune escape potential of the Omicron variant BA.2 make it more difficult to control, and patients with high-risk factors prone to progress rapidly.Purpose: To evaluate YDJDG’s efficacy in treating patients with the Omicron variant BA.2 with high-risk factors and compared it with that of Paxlovid.Methods: A total of 257 patients who fulfilled the inclusion criteria were allocated to the YDJDG (115 cases), Paxlovid (115 cases), and control (27 cases) groups. A Cox regression model was used to analyze the independent factors affecting the shedding time of nucleic acid in 14 days. Propensity score matching (PSM) was used to match the characteristics of individuals in the three groups, while the Kaplan-Meier method was used to compare the shedding proportion of nucleic acids.Results: Cox analysis showed that the vaccine booster (p = 0.006), YDJDG treatment (p = 0.020), and Paxlovid treatment (p &lt; 0.0001) were independent predictors of nucleic acid shedding at 14 days. The median recovery time was 11.49 days in the YDJDG group, 10.21 days in the Paxlovid group, and 13.93 days in the control group. After PSM (3:1), the results showed that the nucleic acid shedding time of the YDJDG group (n = 53) was 2.47 days shorter than that of the control group (n = 21) (p = 0.0076), while the Paxlovid group (n = 44) had a 4.34 days shorter than that of the control group (n = 17) (p &lt; 0.0001). After PSM (1:1), YDJDG and Paxlovid (76 pairs) were also analyzed. In the YDJDG group, nucleic acid shedding time was 1.43 days longer than that observed in the Paxlovid group (p = 0.020). At 10 and 14 days, the Paxlovid group showed a significant difference in the nucleic acid shedding proportion compared with the control group (p = 0.036, p = 0.0015). A significant difference was also observed between the YDJDG and control groups (p = 0.040) at 14 days.Conclusion: As a safe and convenient oral drug, YDJDG can be used as an alternative to antiviral therapy for such patients.
Neuropsychiatric symptoms and altered sleep quality in cerebral small vessel disease
Authors: Li Xi , Qin Rong-Rong , Chen Jian , Jiang Hai-Fei , Tang Pan , Wang Yu-Jing , Xu Dong-Wu , Xu Tao , Yuan Ti-Fei 
Published: August 2022

BackgroundSleep disturbance and neuropsychiatric symptoms are common clinical symptoms of cerebral small vessel disease (CSVD), but the underlying mechanism is unclear. Here, we investigated the relationship between sleep quality and neuropsychiatric performance in patients with CSVD.MethodsA total of 30 patients with CSVD and 35 healthy controls (HCs) were recruited. The 13-item Beck Depression Inventory (BDI-13), Beck Anxiety Inventory (BAI), and Symptom Check List 90 (SCL90) were used to assess depression, anxiety, and other psychological symptoms, respectively. Sleep quality was assessed using Pittsburgh Sleep Quality Index (PSQI), and cognitive function was tested using Montreal Cognitive Assessment (MoCA).ResultsWhen compared to the HC group, the patients with CSVD showed increased anxiety and neuropsychiatric symptoms, worse sleep quality, and impaired cognition (p &lt; 0.05). The prevalence of comorbid poor sleep quality in the patients with CSVD was approximately 46%. The patients with CSVD with poor sleep quality also had more severe neuropsychiatric symptoms. After controlling for demographic variables, sex and anxiety significantly predicted sleep quality.ConclusionThis study suggests that the prevalence of CSVD with poor sleep quality is high, and that sex and anxiety are independent risk factors for CSVD comorbid sleep quality.
A pan-cancer analysis of FAT atypical cadherin 4 (FAT4) in human tumors
Authors: Mao Weili , Zhou Jiajing , Hu Jie , Zhao Kui , Fu Zhenling , Wang Jun , Mao Kaili 
Published: August 2022

ObjectiveWe performed a pan-cancer analysis to explore the potential mechanisms of FAT4 in 33 different tumors.MethodsIn this study, we selected 33 types of cancers based on the datasets of TCGA (the cancer genome atlas). We analyzed the expression of FAT4 in tumor and normal tissues. Meanwhile, we analyzed the expression levels of FAT4 in tissues from tumors of different stages. Kaplan-Meier survival analysis, Tumor Mutational Burden (TMB), Microsatellite Instability (MSI), immune infiltration analysis, Gene set enrichment analysis (GSEA), and FAT4-related gene enrichment analysis were performed.ResultsFAT4 expression in most tumor tissues was lower than in corresponding control tissues. FAT4 expression was different in different stages of bladder cancer (BLCA), kidney clear cell carcinoma (KIRC), and breast cancer (BRCA). In addition, the expression level of FAT4 in different types of tumors has an important impact on the prognosis of patients. FAT4 might influence the efficacy of immunotherapy via tumor burden and microsatellite instability. We observed a statistically positive correlation between cancer-associated fibroblasts and FAT4 expression in most tumors. GSEA of BLCA indicated that low FAT4 expression groups were mainly enriched in calcium signaling pathway and chemokine signaling pathway. GSEA analysis of KIRC suggested low FAT4 expression groups were mainly involved in olfactory transduction and oxidative phosphorylation. Kyoto Encyclopedia of Genes and Genomes (KEGG) indicated that the role of FAT4 in the pathogenesis of cancer may be related to human papillomavirus infection, Hippo signaling pathway, PI3K–Akt signaling pathway, etc. Gene Ontology (GO) enrichment analysis further showed that most of these genes were related to the pathways or cell biology, such as peptidyl–tyrosine phosphorylation, cell junction assembly, protein tyrosine kinase activity, etc.ConclusionOur study summarized and analyzed the antitumor effect of FAT4 in different tumors comprehensively, which aided in understanding the role of FAT4 in tumorigenesis from the perspective of clinical tumor samples. Pan-cancer analysis showed that FAT4 to be novel biomarkers for various cancers prognosis.
A 2 MS/s Full Bandwidth Hall System with Low Offset Enabled by Randomized Spinning
Authors: Riem Robbe , Raman Johan , Rombouts Pieter 
Published: August 2022

In this paper, a Hall plate readout with a randomized four-phase spinning-current scheme is proposed. The goal is to remove the maximum number of offset components, including the offset associated with spike demodulation. The outcome is that only the smallest possible offset remains, corresponding to the residual offset of the Hall plate which cannot be distinguished from the Hall signal. An additional innovation is to operate various offset-reduction loops in spread-spectrum mode, allowing the removal of error components without notching out any in-band signals. The resulting approach delivers a very large notch-free bandwidth while simultaneously reducing the Hall plate residual offset, making it an enabler for high-bandwidth Hall-based current sensors. To demonstrate the proposed techniques, we have realized a mixed-mode experimental circuit, where the analog part is implemented in a custom integrated circuit, and the digital control system in an FPGA is connected to the analog chip. Measurement results feature a Hall readout system with a notch-free bandwidth up to 820 kHz and a 47 μTrms noise floor. The input-referred Hall plate offset, based on statistical measurements on 10 samples from a single wafer, is reduced from 130±22 μT to only 23±22 μT.