bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of immediate removal of urinary catheter after laparoscopic gynecological surgery for benign diseases: A meta‐analysis of randomized controlled trials
Authors: Fu Chun‐Yan , Wan Li , Shen Pei‐Ying , Wang Li‐Zhong 
Published: May 2022

AbstractBackgroundThe proper time for removing the urinary catheter after gynecologic laparoscopy is unclear.ObjectivesTo assess the feasibility of immediate catheter removal after benign gynecologic laparoscopy.Search StrategyPubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and Wanfang Data were searched from inception to November 30, 2021.Selection CriteriaOnly randomized controlled trials published in English or Chinese comparing immediate versus delayed catheter removal after gynecologic laparoscopy for benign diseases were included.Data Collection and AnalysisThe primary outcome was the incidence of postoperative urinary retention (PUR). A random effects model was used to calculate pooled relative risk (RR) and 95% confidence interval (CI).Main ResultsSix studies were included in this meta‐analysis. There was no significant difference in PUR between immediate and delayed catheter removal (RR 1.51, 95% CI 0.37–6.18), but the evidence was of very low quality. Subgroup analysis according to the type of surgery showed a higher rate of PUR with immediate removal after hysterectomy than after other surgeries. Immediate removal was associated a lower incidence of urinary tract infection and a shorter time to mobilization compared with delayed removal.ConclusionsImmediate removal of the urinary catheter is feasible and beneficial after benign gynecologic laparoscopy.
Placenta accreta spectrum—A single‐center retrospective observational cohort study of multidisciplinary management over time
Authors: Uddén Alice , Carlsson Ylva , Karlsson Ove , Peeker Ralph , Svanvik Teresia 
Published: May 2022

AbstractObjectiveTo evaluate whether the results of a previous study that showed a decrease in blood loss and transfusions with a multidisciplinary approach, including a fixed team when delivering women diagnosed with placenta accreta spectrum at Sahlgrenska University Hospital, remained low throughout time, and to investigate hospital stay and maternal and neonatal complications during a time period with varying team structure compared with previous periods.MethodsA retrospective observational cohort study comparing data from medical records including three cohorts of women diagnosed with placenta accreta spectrum between October 2003 and December 2020. Cohort 1 consisted of women delivered before the multidisciplinary approach was introduced. Cohort 2 and cohort 3 were both managed in a multidisciplinary manner, but while cohort 2 was managed by a fixed team, cohort 3 was managed by several different senior specialists. The data were analyzed using Kruskal‐Wallis test.ResultsBlood loss and need for transfusion were significantly lower for cohort 3 and cohort 2 compared with cohort 1. No significant difference was found between cohort 3 and cohort 2.ConclusionThe multidisciplinary management and surgical method employed at Sahlgrenska University Hospital have lowered blood loss and the need for transfusions, even over time.
Coexisting overactive–underactive bladder and detrusor overactivity–underactivity in pelvic organ prolapse
Authors: Frigerio Matteo , Barba Marta , Cola Alice , Spelzini Federico , Milani Rodolfo , Manodoro Stefano 
Published: May 2022

AbstractObjectiveThe coexisting overactive–underactive bladder (COUB) syndrome could be related to the increased urethral resistance caused by severe pelvic organ prolapse (POP). We aimed to evaluate the clinical and urodynamic findings of patients with COUB and/or detrusor overactivity–underactivity (DOU) in a cohort of patients scheduled for POP surgery and the possible risk factors of COUB after surgery.MethodsThis retrospective study analyzed all patients who underwent POP repair between 2008 and 2013, excluding women with a history of pelvic floor surgery. Patients were divided into COUB and non‐COUB according to baseline symptoms and into DOU and non‐DOU based on urodynamic findings. A multivariate model was performed to identify risk factors for COUB symptoms after surgery.ResultsA total of 533 women underwent POP surgery. Preoperatively, patients with COUB had more severe anterior compartment prolapse (Pelvic Organ Prolapse Quantification staging system Aa point, P = 0.008) and more frequently had overactive bladder compared with controls (P = 0.023). The rate of COUB decreased significantly after surgery. Preoperative opening detrusor pressure resulted as the only independent predictor of postoperative COUB symptoms (P = 0.034).ConclusionPOP is a valid pathogenetic model for COUB development. POP repair induced a significant decrease in COUB symptoms with low opening detrusor pressure resulting as the only independent predictor of postoperative COUB.
Efficacy of pembrolizumab rechallenge for metastatic urothelial carcinoma
Authors: Nishimura Nobutaka , Miyake Makito , Shimizu Takuto , Tachibana Akira , Tanaka Nobumichi , Fujimoto Kiyohide 
Published: May 2022

IntroductionBefore the approval of enfortumab vedotin, no standard treatment was available as the salvage treatment for patients with metastatic urothelial carcinoma who had failed second‐line or later pembrolizumab. Pembrolizumab rechallenge is one of the options for these patients, but there is limited evidence on the effectiveness of pembrolizumab rechallenge. We report three patients with metastatic urothelial carcinoma treated with pembrolizumab rechallenge and discuss rechallenge of immune checkpoint inhibitors in other malignancies.Case presentationThis study included three cases treated with pembrolizumab rechallenge with the age of 54 (Case 1), 78 (Case 2), and 67 (Case 3) years old. A complete response to the prior pembrolizumab was observed only in Case 1. However, no patients responded to the pembrolizumab rechallenge.ConclusionPembrolizumab rechallenge is not recommended in the current clinical setting of metastatic urothelial carcinoma, even for patients who showed complete response to the prior pembrolizumab.
Training soccer goalkeeping skills: Is video modeling enough?
Authors: Capalbo Alexandra , Miltenberger Raymond G. , Cook Jennifer L. 
Published: May 2022

Scant literature exists assessing the effectiveness of video modeling (VM) alone in the sports literature. Further evaluations of VM to improve sports skills is warranted because VM is an accessible and efficient procedure that has successfully improved skills in other fields of practice (e.g., staff training, medical procedures). Additionally, behavior analysts have not evaluated interventions for improving goalkeeping skills for individual soccer players. Therefore, we replicated the 1 behavior‐analytic sports study on VM (Quinn et al., 2020), using a multiple baseline design across behaviors to evaluate the effects of VM and VM + video feedback (VF) to train 3 goalkeeper skills to two 9‐year‐old soccer players. The results showed that, although VM had some effect on performance compared to baseline, VM + VF resulted in the robust outcomes necessary for proficient performance of the goalkeeper skills. We discuss the results and limitations.
Resilience during a great economic recession: Social and personal resources for youth's positive adaptation in the school context
Authors: Motti‐Stefanidi Frosso , Pavlopoulos Vassilis , Mastrotheodoros Stefanos , Asendorpf Jens B. 
Published: May 2022

AbstractIntroductionGreece was hit particularly hard by the latest economic recession.MethodUsing a quasi‐experimental design, we examined whether and how psychosocial resources promoted and/or protected youth's school adjustment (academic achievement, school engagement, and conduct) and psychological well‐being (absence of emotional symptoms) during the economic crisis. We focused on three family resources (family economic well‐being, parental education, and school involvement) and one personal resource (self‐efficacy). Data were collected with multiple methods and informants. We compared two cohorts of adolescents, closely matched through Inverse Probability of Treatment Weighting, who lived in the same neighborhoods, one before (2005; N = 1057; age M = 12.7 years) and the other during (2013; N = 1052; age M = 12.6 years) the economic recession.ResultsVariable‐ and person‐focused analyses revealed that in the context of the economic recession parental education and parental school involvement promoted and/or protected youth's school adjustment, and families' economic wellbeing was linked to both externalizing and internalizing symptoms. Another key finding is that youth who exhibited positive adaptation during the economic crisis were equally well adjusted as youth who were well adjusted before the economic crisis, even though they had fewer resources. Finally, youth with more adequate psychosocial resources were able to keep the same high level of adaptation during the crisis as well‐adjusted youth had before the crisis. The findings were robust regarding variations in gender and immigrant status.ConclusionThe results suggest that psychosocial resources are important in understanding the diversity in youth's school adjustment and well‐being during a major economic crisis.
Assessment of professional self‐efficacy in psychological interventions and psychotherapy sessions: Development of the Therapist Self‐Efficacy Scale (T‐SES) and its application for eTherapy
Authors: Gori Alessio , Topino Eleonora , Brugnera Agostino , Compare Angelo 
Published: May 2022

AbstractObjectiveThis study aimed to develop the Therapist Self‐Efficacy Scale (T‐SES), and test its validity in a sample of Italian mental health therapists, to assess their professional self‐efficacy concerning their practice of eTherapy in a synchronous video‐based setting.MethodsA sample of 322 Italian mental health professionals (37.6% psychologists, 62.4% psychotherapists; Mage = 38.48, SD = 8.509) completed an online survey.ResultsThe T‐SES showed a clear, one‐factor structure with good psychometric properties. Significant associations were found with insight orientation, general self‐efficacy, self‐esteem, and personality traits of openness, conscientiousness, and agreeableness. The results showed no differences between psychologists and psychotherapists, or differences based on years of experience.ConclusionThe T‐SES is an agile and versatile self‐report measure for mental health professionals to assess their self‐efficacy concerning their therapeutic activity, which can provide information for tailoring training for eTherapy.
What protein kinases are crucial for acantholysis and blister formation in pemphigus vulgaris? A systematic review
Authors: Brescacin Adriano , Baig Zunaira , Bhinder Jaspreet , Lin Sen , Brar Lovejot , Cirillo Nicola 
Published: May 2022

AbstractPemphigus vulgaris (PV) is a potentially fatal autoimmune blistering disease characterized by cell–cell detachment (or acantholysis) and blister formation. While the signaling mechanisms that associate with skin/mucosal blistering are being elucidated, specific treatment strategies targeting PV‐specific pathomechanisms, particularly kinase signaling, have yet to be established. Hence, the aim of this review was to systematically evaluate molecules in the class of kinases that are essential for acantholysis and blister formation and are therefore candidates for targeted therapy. English articles from PubMed and Scopus databases were searched, and included in vitro, in vivo, and human studies that investigated the role of kinases in PV. We selected studies, extracted data and assessed risk of bias in duplicates and the results were reported according to the methodology outlined by the Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA). The risk of bias assessment was performed on in vivo studies utilizing SYRCLE's risk of bias tool. Thirty‐five studies were included that satisfied the pathogenicity criterion of kinases in PV, the vast majority being experimental models that used PV sera (n = 13) and PV‐IgG (n = 22). Inhibition of kinase activity (p38MAPK, PKC, TK, c‐Src, EGFR, ERK, mTOR, BTK, and CDK2) was achieved mostly by pharmacological means. Overall, we found substantial evidence that kinase inhibition reduced PV‐associated phosphorylation events and keratinocyte disassociation, prevented acantholysis, and blocked blister formation. However, the scarce adherence to standardized reporting systems and the experimental protocols/models used did limit the internal and external validity of these studies. In summary, this systematic review highlighted the pathogenic intracellular events mediated by kinases in PV acantholysis and presented kinase signaling as a promising avenue for translational research. In particular, the molecules identified and discussed in this study represent potential candidates for the development of mechanism‐based interventions in PV.
Use of a chatbot to increase uptake of cascade genetic testing
Authors: Schmidlen Tara , Jones Claire L. , Campbell‐Salome Gemme , McCormick Cara Z. , Vanenkevort Erin , Sturm Amy C. 
Published: May 2022

AbstractSuccessful proband‐mediated family communication and subsequent cascade genetic testing uptake requires interventions that present information clearly, in sufficient detail, and with medical authority. To facilitate family communication for patients receiving clinically actionable results via the MyCode® Community Health Initiative, a Family Sharing Tool (FST) and a cascade chatbot were developed. FST is an electronic mechanism allowing patients to share genetic test results with relatives via chatbot. The cascade chatbot describes the proband's result, associated disease risks, and recommended management and captures whether the user is a blood relative or caregiver, sex, and relationship to the proband. FST and cascade chatbot uptake among MyCode® probands and relatives was tracked from August 2018 through February 2020. Cascade genetic testing uptake was collected from testing laboratories as number of cascades per proband. Fifty‐eight percent (316/543) of probands consented to FST; 42% (227/543) declined. Receipt preferences were patient electronic health record (EHR) portal (52%), email (29%), and text (19%). Patient EHR portal users (p < 0.001) and younger patients were more likely to consent (p < 0.001). FST was deployed to 308 probands. Fifty‐nine percent (183/308) opened; of those, 56% (102/183) used FST to send a cascade chatbot to relatives. These 102 probands shared a cascade chatbot with 377 relatives. Sixty‐two percent (235/377) of relatives opened; of these, 69% (161/235) started, and of these, 57% (92/161) completed the cascade chatbot. Cascade genetic testing uptake was significantly greater among relatives of probands who consented to the FST (M = 2.34 cascades, SD = 2.10) than relatives of probands who declined (M = 1.40 cascades, SD = 0.82, p < 0.001). Proband age was not a significant predictor of cascade genetic testing uptake. Further work is needed to better understand factors impacting proband use of FST and relative use of cascade chatbots.
2022 update on the scientific premise and clinical trials for IL-15 agonists as cancer immunotherapy
Authors: Peng Yingjun , Fu Shengyu , Zhao Qi 
Published: May 2022

AbstractDiverse cytokines and their receptors on immune cells constitute a highly complex network in the immune system. Some therapeutic cytokines and their derivatives have been approved for cancer treatment. IL-15 is an immune-regulating cytokine with multiple functions, among which the function of activating the immunity of cancer patients has great potential in cancer immunotherapy. In this review, we introduce the functions of IL-15 and discuss its role in regulating the immune system in different immune cells. Meanwhile, we will address the applications of IL-15 agonists in cancer immunotherapy and provide prospects for the next generation of therapeutic designs. Although many challenges remain, IL-15 agonists offer a new therapeutic option in the future direction of cancer immunotherapy.
Receptor binding domain proteins of SARS‐CoV‐2 variants produced inNicotiana benthamianaelicit neutralizing antibodies against variants of concern
Authors: Khorattanakulchai Narach , Manopwisedjaroen Suwimon , Rattanapisit Kaewta , Panapitakkul Chalisa , Kemthong Taratorn , Suttisan Nutchanat , Srisutthisamphan Kanjana , Malaivijitnond Suchinda , Thitithanyanont Arunee , Jongkaewwattana Anan , Shanmugaraj Balamurugan , Phoolcharoen Waranyoo 
Published: May 2022

AbstractThe constantly emerging severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) variants of concerns (VOCs) with mutations in the receptor‐binding domain (RBD) spread rapidly and has become a severe public health problem worldwide. Effective vaccines and optimized booster vaccination strategies are thus highly required. Here, the gene encoding six different RBD (Alpha, Beta, Gamma, Kappa, Delta, and Epsilon variants) along with the Fc fragment of human IgG1 (RBD‐Fc) was cloned into plant expression vector and produced inNicotiana benthamianaby transient expression. Further, the immunogenicity of plant‐produced variant RBD‐Fc fusion proteins were tested in cynomolgus monkeys. Each group of cynomolgus monkeys was immunized three times intramuscularly with variant RBD‐Fc vaccines at Day 0, 21, 42, and neutralizing antibody responses were evaluated against ancestral (Wuhan), Alpha, Beta, Gamma, and Delta variants. The results showed that three doses of the RBD‐Fc vaccine significantly enhanced the immune response against all tested SARS‐CoV‐2 variants. In particular, the vaccines based on Delta and Epsilon mutant RBD elicit broadly neutralizing antibodies against ancestral (Wuhan), Alpha, and Delta SARS‐CoV‐2 variants whereas Beta and Gamma RBD‐Fc vaccines elicit neutralizing antibodies against their respective SARS‐CoV‐2 strains. The Delta and Epsilon RBD‐Fc based vaccines displayed cross‐reactive immunogenicity and might be applied as a booster vaccine to induce broadly neutralizing antibodies. These proof‐of‐concept results will be helpful for the development of plant‐derived RBD‐Fc‐based vaccines against SARS‐CoV‐2 and its variants.
Surface wind over Europe: Data and variability
Authors: Rojas‐Labanda Cristina , González‐Rouco Fidel , García‐Bustamante Elena , Navarro Jorge , Lucio‐Eceiza Etor E. , Van der Schrier Gerard , Kaspar Frank 
Published: May 2022

AbstractThis work improves the characterization and knowledge of the surface wind climatology over Europe with the development of an observational database with unprecedented quality control (QC), the European Surface Wind Observational database (EuSWiO). EuSWiO includes more than 3,829 stations with sub‐daily resolution for wind speed and direction, with a number of sites spanning the period of 1880–2017, a few hundred time series starting in the 1930s and relatively good spatial coverage since the 1970s. The creation of EuSWiO entails the merging of eight different data sets and its submission to a common QC. About 5% of the total observations were flagged, correcting a great part of the extreme and unrealistic values, which have a discernible impact on the statistics of the database. The daily wind variability was characterized by means of a classification technique, identifying 11 independent subregions with distinct temporal wind variability over the 2000–2015 period. Significant decreases in the wind speed during this period are found in five regions, whereas two regions show increases. Most regions allow for extending the analysis to earlier decades. Caution in interpreting long‐term trends is needed as wind speed data have not been homogenized. Nevertheless, decreases in the wind speed since the 1980s can be noticed in most of the regions. This work contributes to a deeper understanding of the temporal and spatial surface wind variability in Europe. It will allow from meteorological to climate and climate change studies, including potential applications to the analyses of extreme events, wind power assessments or the evaluation of reanalysis or model‐data comparison exercises at continental scales.
Type 2 Diabetes mellitus treatment intensification and deintensification in primary care: a retrospective cohort study
Authors: Wong Jay An , Young Isabel , Sim Ruth , Kua Kok Pim , Lee Shaun Wen Huey 
Published: May 2022

AbstractThe prevalence of type 2 diabetes is increasing worldwide, presenting a considerable clinical and public health burden. Existing evidence demonstrates that optimisation of diabetes treatment regimens can reduce the risk of morbidity and disability. This retrospective observational cohort study aimed to identify factors associated with treatment intensification and deintensification in people with type 2 diabetes and evaluate effects of the treatment approaches on clinical outcomes. The cohort included 183 patients enrolled in a primary care Diabetes Medication Therapy Adherence Clinic program in Malaysia between 1 January 2016 and 31 March 2020. Multivariable logistic regression analyses were conducted to determine the clinical or socio‐demographic characteristics associated with treatment intensification or deintensification. A total of 175 patients were included in the final analysis. Eighty‐seven patients (49.7%) had their medicine regimens changed, of which 27.4% (n = 48) of patients had their medicines intensified, 8.6% (n = 15) of patients had their medicines deintensified, and 13.7% (n = 24) of patients had their medicines intensified and deintensified. In multivariable analyses, treatment intensification was associated with higher knowledge of medicine scores. No factors were significantly associated with treatment deintensification. Patients who had their medicines intensified and deintensified had a lower post follow‐up target glycated haemoglobin level, fasting plasma glucose, and random blood glucose values compared to the baseline. The study found variability in the frequency of intensification or deintensification of diabetes medicine regimens and the factors associated with it. Treatment deintensification was relatively uncommon. To prevent overtreatment, further investigations are warranted to understand the impact of treatment deintensification on patients who were already receiving intensive therapy for type 2 diabetes.
Larger trees may support larger Indiana bat maternity colonies in a dynamic landscape
Authors: Cable Ashleigh B. , Hohoff Tara C. , Deppe Jill L. , Taylor Steven J. , Davis Mark A. 
Published: May 2022

AbstractIndiana bats (Myotis sodalis), federally listed as endangered, are of management concern in eastern North America. While researchers quantified the habitat affinities of the species throughout the range, few studies have occurred in regions where populations are at high risk for wind energy development and changing climes. Central Illinois, USA, is a dynamic landscape where forest area has been increasing in recent decades (on public and private land) because of changing farming practices and increased habitat protections. The increasing availability of large diameter trees, increasing forest biomass, and changing forest compositions have the potential to influence Indiana bat roost habitat preferences. We assessed Indiana bat maternity roost selection at the tree and forest plot scale to characterize patterns of use in this region from 2017–2018. We predicted that large trees on the landscape would support large colonies of Indiana bats. We located bats in multiple species of trees including elm (Ulmus spp.), cottonwood (Populus deltoides), and shagbark hickory (Carya ovata). We documented larger maternity colonies sharing roosts than in previous studies from the 1980s in the same region. We suggest managers and regulatory agencies monitor Indiana bats in dynamic landscapes such as those with changing forest composition and biomass.