bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significant relationship between Arctic warming and East Asia hot summers
Authors: Kim Da‐Seul , Jun Sang‐Yoon , Lee Myong‐In , Kug Jong‐Seong 
Published: August 2022

AbstractArctic warming is of growing interest because it could affect midlatitude climates. Even though numerous studies have paid attention to the relationship between Arctic warming and the midlatitude climate in winter, the influence of Arctic warming on the summer conditions has not been examined in depth. Here we identify a significant relationship between East Asia hot summers and Arctic warming over the Barents and Kara seas. To represent Arctic warming, we define a combined index by simply differencing the normalized surface air temperature and sea‐ice indices. We found that the combined index in July has significantly high correlations with the temperatures in China, Korea, and Japan. While the teleconnection mechanism is not completely revealed, it is evident that warming over the Barents and Kara seas is accompanied by the local development of an anomalous anticyclone and downstream wave trains, which yield a strong anticyclonic circulation over East Asia and the North Pacific. The anticyclonic circulation persists and intensifies until August, which leads to hot summer conditions in East Asia with warm advection and enhanced shortwave radiation. Our results suggest that Arctic climate conditions can be used as a useful precursor of East Asia temperature variations even in summer.
The inseparable two: Impact of prior success and failure on new product development project discontinuation
Authors: Lévesque Moren , Subramanian Annapoornima M. , Vrande Vareska Van De 
Published: August 2022

AbstractNew product development (NPD) is a risky and expensive endeavor. Therefore, discontinuing less promising NPD projects, based on their development trajectories, is very important, yet firms face challenges when deciding whether and when to discontinue NPD projects. This article examines how characteristics of a firm's prior success and failure experiences, such as the number of launched and discontinued past projects, their attributes (i.e., the codification and quality of the knowledge underlying these past projects), and their level of relatedness (i.e., similarity) to current projects, influence the risks of continuing and discontinuing NPD projects, thus impacting their future discontinuation decisions. We adopt a mixed method approach, where we formally model and empirically test the influence of prior experiences on future decision‐making. A formal model enables us to offer reasoning that considers the risks of continuing a project versus discontinuing that project as the basis for theoretical arguments for a set of proposed testable relationships. We then empirically test these relationships on 2938 new drug development projects of biopharma firms worldwide. We find that firms with a greater amount of success and failure experiences tend to discontinue less promising NPD projects sooner than firms with less success and failure experiences. Also, we find that while the attributes (particularly knowledge codification) of successful experiences predominantly helped firms decide on timely discontinuation, failure experiences influenced firms' decision on timely discontinuation only when the projects were closely related to their failure experiences.
Wasserstoffwirtschaft: In Japan und in Deutschland
Authors: Franz Adam W. , Kirchhoff Tobias , Möller Alexander , Schmid , Rolf , Zimbardi Christopher 
Published: August 2022

AbstractOb in der Industrie, im Verkehr oder zum Heizen: Saubere Energie ist überall nötig, um die Klimaziele zu erreichen und den Übergang zur Kohlenstoffneutralität zu gewähren. Wasserstoff gilt dabei als Alternative zu fossilen Brennstoffen und stößt weltweit auf Interesse und Investitionen.
9th Carnival Conference Session 2022 (CCS‐2022)
Authors: Bruns Jörn , Disch Sabrina , Strub Erik , Rasche Bertold 
Published: August 2022

AbstractZum 9. Mal fand in diesem Jahr am Department Chemie der Universität Köln die „Carnival Conference Session“ (CCS‐2022) mit etwa 50 Teilnehmer:innen statt. Corona hatte den ursprünglich karnevalistischen Termin dieses Jahr in den Sommer verschoben. Zur CCS werden aufstrebende Forscher:innen aus allen Bereichen der Chemie nach Köln eingeladen. Die Vorträge adressieren Forschende aus den Arbeitsgruppen und Studierende. Das interdisziplinäre Programm bestand in diesem Jahr aus vier Vorträgen und bot Einblicke in die Spektroskopie, die Batterieforschung, das Züchten von Volumenkristallen und die Hochdruckchemie von Uran.
An interim analysis of a gestational weight gain intervention in military personnel and other TRICARE beneficiaries
Authors: Estevez Burns Rosemary , Hare Marion E. , Andres Aline , Klesges Robert C. , Talcott Gerald Wayne , LeRoy Karen , Little Melissa A. , Hyrshko‐Mullen Ann , Waters Teresa M. , Harvey Jean R. , Bursac Zoran , Krukowski Rebecca A. 
Published: August 2022

AbstractObjectiveDespite military fitness regulations, women in the military frequently experience overweight/obesity, excessive gestational weight gain (GWG), and the postpartum implications. This interim analysis of the Moms Fit 2 Fight study examines GWG outcomes among active‐duty personnel and other TRICARE beneficiaries who received a stepped‐care GWG intervention compared with those who did not receive a GWG intervention.MethodParticipants (N = 430; 32% identified with an underrepresented racial group, 47% were active duty) were randomized to receive a GWG intervention or the comparison condition, which did not receive a GWG intervention.ResultsRetention was 88% at 32 to 36 weeks' gestation. Participants who received the GWG intervention gained less weight compared with those who did not (mean [SD] = 10.38 [4.58] vs. 11.80 [4.87] kg, p = 0.0056). Participants who received the intervention were less likely to have excessive GWG compared with those who did not (54.6% vs. 66.7%, p = 0.0241). The intervention effects were significant for participants who identified as White, but not for those of other racial identities. There were no significant differences between the conditions in maternal/neonatal outcomes.ConclusionsThe intervention successfully reduced excessive GWG, particularly among participants who identified as White. Should this intervention be found cost‐effective, it may be sustainably integrated throughout the military prenatal care system.
Integrative proteomics and phosphoproteomics profiling on osteogenic differentiation of periodontal ligament stem cell
Authors: Ning Tingting , Ning Caiyu , Li Siwei , Mo Chuzi , Liu Zhao , Wang He 
Published: August 2022

AbstractThis study aims to elucidate the phosphorylated profile of periodontal ligament stem cells (PDLSCs) osteogenic differentiation, which contributes to the promotion of periodontium regeneration. PDLSCs cultured in the osteogenic induction medium for 14 days were analyzed by proteomics and phosphoproteomics. Potential functions of phosphorylated differentially expressed proteins (DEPs) were annotated and enriched based on Gene Ontology (GO). Furtherly, overlapped DEPs were identified and conducted protein–protein interaction (PPI) network united with the top 20 up/downregulated phosphorylated DEPs. Hub phosphorylated DEPs were analyzed by Cytoscape, and the protein kinase phosphorylation network was predicted by iGPS. Proteomics identified 87 upregulated and 227 downregulated DEPs. Phosphoproteomics identified 460 upregulated and 393 downregulated phosphorylated DEPs, and they were primarily enriched in mitochondrial function and ion‐channel related terms. Furthermore, 63 overlapped DEPs were recognized for more accurate predictions. Among the top 10 hub phosphorylated DEPs, only Integrin alpha‐5 (ITGA5) expressed upregulated phosphorylation, and half of them belonged to extracellular matrix (ECM) proteins. In addition, numerous kinases corresponding to four interactive hub phosphorylated DEPs were predicted, including Collagen alpha‐2(I) (COL1A2), Syndecan‐1 (SDC1), Fibrillin‐1 (FBN1), and ITGA5. Our findings established a basis for further elucidation of the phosphorylation of PDLSCs osteogenic differentiation, and COL1A2/SDC1/ITGA5/FBN1 phosphorylated network may dominate this process.
A framework to understand the social impacts of agricultural trade
Authors: Schaafsma Marije , Dreoni Ilda , Ayompe Lacour Mody , Egoh Benis , Ekayana Dewa Putu , Favareto Arilson , Mumbunan Sonny , Nakagawa Louise , Ngouhouo‐poufoun Jonas , Sassen Marieke , Uehara Thiago Kanashiro , Matthews Zoe 
Published: August 2022

AbstractWhile international trade in agricultural commodities can spur economic development especially where governance is strong, there are also concerns about the local impacts of commodity production and their distribution. Previous frameworks have primarily focused on trade effects on environmental conditions in production regions, as well as economic growth and food security. Instead, we develop a conceptual framework for understanding the impact of agricultural trade on multidimensional wellbeing and equity. The purpose of the framework is to guide the analysis of the impacts of trade on people, by identifying the core concepts and organising the complexity of the local social impacts of global value chains. The framework is supported by evidence from studies on trade in soy, coffee, cocoa, and palm oil.
Towards sustainable development in the European Union countries: Does economic complexity affect renewable and non‐renewable energy consumption?
Authors: Can Muhlis , Ahmed Zahoor 
Published: August 2022

AbstractEnergy insecurity and unsustainable development associated with traditional energy consumption are major challenges for nations. In this context, finding the different parameters that could influence energy use is essential for sustainable development strategies. Unquestionably, the economic structure of nations can influence energy usage; however, the limited literature on this topic delved into the impact of economic complexity on non‐renewable energy usage. Hence, this study extends the literature and tests the effect of knowledge‐based economic structure (economic complexity) on renewable and non‐renewable energy consumption in 14 European Union countries from 1990 to 2017 using the methods robust against both heterogeneity and cross‐sectional dependence. The long‐run empirical results established that economic complexity increases renewable energy and decreases non‐renewable energy use. Also, economic complexity Granger causes non‐renewable energy while feedback effect exists between renewable energy and economic complexity. Based on the results, policies are discussed for promoting sustainable growth.
Experimental and numerical studies on mechanical behavior of stiffened concrete‐filled square steel tube columns subjected to axial compression
Authors: Sun Yanyan , Xu Jing , Zuo Gong 
Published: August 2022

AbstractIn this study, nine square concrete‐filled steel tubular (SCFST) columns considering longitudinal stiffeners as parameters were produced to investigate the axial compression mechanical properties of SCFST columns in the condition of constant steel consumption. This included one specimen without stiffeners, three specimens stiffened with one stiffener on each tube wall, two specimens stiffened with two stiffeners on each tube wall, two specimens stiffened with three stiffeners on each tube wall and one specimen stiffened with four stiffeners on each tube wall. Simultaneously, numerical simulations were performed under identical conditions using ABAQUS software. The results showed that the longitudinal stiffeners can act as an out‐of‐plane restriction support to delay the development of local buckling of the steel tube, which indirectly improved the constraint effect of steel tube on core concrete. First, both the number of local buckling and the ultimate displacement of the specimens grew correspondingly when the number of stiffeners increased. As the sub‐wall width‐to‐thickness ratio was increased, the steel tube became prone to local buckling. Second, the installation of stiffeners decreased the confinement effect of steel tube on the core concrete, in which the sub‐wall width‐to‐thickness ratio and the stiffener width‐to‐thickness ratio had a great influence on the ultimate bearing capacity of the specimens. Further, the experimental outcomes indicated that the bearing capacity of stiffened specimens was less than that of the unstiffened specimen. The bearing capacity of the specimens stiffened with three and four stiffeners was higher than that of the specimens stiffened with one and two stiffeners. Third, the stiffener width‐to‐thickness ratio had a considerable impact on the ductility of the specimens. The ductility of specimens stiffened with one and two stiffeners was greater than that of the specimens stiffened with three and four stiffeners. Finally, the finite element simulations were consistent with the experimental process. The confinement factor of stiffened specimens became enlarged when either the number of stiffeners in the same thickness condition increased or the thickness of steel tube wall under condition of the same number of stiffeners grew.
Sparse kernel models provide optimization of training set design for genomic prediction in multiyear wheat breeding data
Authors: Lopez‐Cruz Marco , Dreisigacker Susanne , Crespo‐Herrera Leonardo , Bentley Alison R , Singh Ravi , Poland Jesse , Shrestha Sandesh , Huerta‐Espino Julio , Govindan Velu , Juliana Philomin , Mondal Suchismita , Pérez‐Rodríguez Paulino , Crossa Jose 
Published: August 2022

AbstractThe success of genomic selection (GS) in breeding schemes relies on its ability to provide accurate predictions of unobserved lines at early stages. Multigeneration data provides opportunities to increase the training data size and thus, the likelihood of extracting useful information from ancestors to improve prediction accuracy. The genomic best linear unbiased predictions (GBLUPs) are performed by borrowing information through kinship relationships between individuals. Multigeneration data usually becomes heterogeneous with complex family relationship patterns that are increasingly entangled with each generation. Under these conditions, historical data may not be optimal for model training as the accuracy could be compromised. The sparse selection index (SSI) is a method for training set (TRN) optimization, in which training individuals provide predictions to some but not all predicted subjects. We added an additional trimming process to the original SSI (trimmed SSI) to remove less important training individuals for prediction. Using a large multigeneration (8 yr) wheat (Triticum aestivum L.) grain yield dataset (n = 68,836), we found increases in accuracy as more years are included in the TRN, with improvements of ∼0.05 in the GBLUP accuracy when using 5 yr of historical data relative to when using only 1 yr. The SSI method showed a small gain over the GBLUP accuracy but with an important reduction on the TRN size. These reduced TRNs were formed with a similar number of subjects from each training generation. Our results suggest that the SSI provides a more stable ranking of genotypes than the GBLUP as the TRN becomes larger.
BDNF mediates improvement in cognitive performance after computerized cognitive training in healthy older adults
Authors: Nicastri Casey M. , McFeeley Brittany M. , Simon Sharon S. , Ledreux Aurélie , Håkansson Krister , Granholm Ann‐Charlotte , Mohammed Abdul H. , Daffner Kirk R. 
Published: August 2022

AbstractIntroductionThe often‐cited mechanism linking brain‐derived neurotrophic factor (BDNF) to cognitive health has received limited experimental study. There is evidence that cognitive training, physical exercise, and mindfulness meditation may improve cognition. Here, we investigated whether improvements in cognition after these three types of structured interventions are facilitated by increases in BDNF.MethodsA total of 144 heathy older adults completed a 5‐week intervention involving working memory/cognitive training, physical exercise, mindfulness meditation, or an active control condition. Serum BDNF levels and Digit Symbol Test (DST) performance were measured pre‐ and post‐intervention.ResultsLinear mixed models suggested that only the cognitive training group demonstrated augmentation of BDNF and DST performance relative to the control condition. Path analysis revealed that changes in BDNF mediate intervention‐related improvement in task performance. Regression analyses showed that, across all intervention conditions, increased BDNF levels were associated with increased DST scores.DiscussionThis study appears to be the first to suggest that BDNF helps mediate improvements in cognition after working memory training in healthy older adults.Highlights
Older adults were randomized to physical activity, mindfulness, cognitive training (computerized cognitive training (CCT), or control.
CCT, but no other condition, led to increased serum brain‐derived neurotrophic factor (BDNF) levels.
CCT led to improvement on the untrained Digit Symbol Test (DST) of speed/working memory.
Path analysis: increases in BDNF mediate intervention‐related improvement on DST.
Increases in BDNF associated with improved DST across all experimental groups.
VASCULAR ENDOTHELIAL GROWTH FACTOR INDUCES PROTEIN KINASE C (PKC)‐DEPENDENT Akt/PKB ACTIVATION AND PHOSPHATIDYLINOSITOL 3′‐KINASE‐MEDIATED PKCδ PHOSPHORYLATION: ROLE OF PKC IN ANGIOGENESIS
Authors: Gliki Georgia , Wheeler‐Jones Caroline , Zachary Ian 
Published: August 2022

AbstractActivation of the protein kinase Akt/PKB mediates VEGF‐dependent endothelial cell survival and eNOS activation. Here we examined the role of PKC in mediating VEGF‐induced Akt activation. The PKC inhibitors GF109203X and calphostin C inhibited VEGF‐induced Akt activation. Rottlerin and Go6976, inhibitors with specificities for PKCδ and α, respectively, also strongly inhibited VEGF‐induced Akt activation. VEGF‐induced Akt activation was prevented by down‐regulation of PKC induced by prolonged pretreatment with the phorbol ester, PMA. VEGF induced phosphorylation of PKCδ at Thr 505 in the activation loop, and this phosphorylation was inhibited by LY294002, suggesting that modulation of PKCδ activation by VEGF occurs distal to phosphatidylinositol 3′‐kinase. PKC and PI3K inhibitors both strongly reduced the stimulation of branching tubulogenesis by VEGF in vitro. The finding that PKC mediates VEGF‐induced Akt activation identifies a novel signal transduction pathway through which Akt can be regulated by growth factors acting through receptor protein tyrosine kinases, and indicates that PKC‐mediated Akt activity may play an essential role in VEGF‐stimulated angiogenesis.
SPECIFIC MONOCLONAL ANTIBODIES AGAINST THE SURFACE OF RAT ISLET β CELLS
Authors: Konidaris Constantinos , Simonson Will , Michelsen Birgitte , Papadopoulos George K. 
Published: August 2022

AbstractType 1 diabetes arises from the autoimmune destruction of islet β cells, with the participation of both arms of the immune system. To better characterize the β cell membrane, we have raised monoclonal antibodies to the surface of the INS‐1 insulinoma cell line. Twenty‐two such antibodies were produced, 21 of the IgG class, all reactive to different cell membrane proteins from INS‐1 and neonatal islet cells, yielding identical electrophoresis patterns, with molecular weights mainly between 45 and 60kD. We have focused on three such antibodies that recognize different protein targets, and are specific for islet β cells. The target protein of antibody AA4, also found on monkey islets, is expressed at significantly higher levels on β cells (55.8 vs 30.6% of cells, plus 3–4 fold increase in average fluorescence intensity per cell) when neonatal rat islet cells are incubated with high (16mM vs 3mM) glucose concentrations. Further identification of the target antigens is in progress and is expected to shed more light on the properties of β cell membrane proteins, and their probable participation in various disease processes.
Contested Urban Green Space Development: Rolling Back the Frontiers of Sustainability in Trondheim, Norway
Authors: Loewen Bradley , Larssæther Stig , Gohari-Krangsås Savis , Vinge Heidi , Temeljotov-Salaj Alenka 
Published: August 2022

AbstractOngoing urban densification in Nordic regions raises sustainability trade-offs related to compactness, land use and urban green space. In Norway, green spaces comprising both natural and agricultural areas are highly valued cultural landscapes protected by the status of ‘green structure’. Yet, neoliberal development forces put pressure on urban green spaces, potentially exacerbating social inequalities and challenging governance structures formally oriented towards sustainability. In the case of Trondheim, Norway, competing priorities under development pressures unfold in the upholding of urban green space strategies and public values between core and periphery areas. Based on interviews, popular media and policy analysis, this contribution uses the multi-actor perspective to compare two current cases of urban development in green areas in terms of shifting public discourses. The first covers development in the urban fringe, where land reserved for agricultural use succumbs to suburban development pressure. The second turns to development in urban green space at the central university campus, used by the public for parkland and recreation, which bowed to public pressure. The examples point to differing values regarding urban green space in core versus periphery areas that materialise in public opposition, triggering debate and institutional review. Compared to state and market sectors, the community sector is shown to be underrepresented in the processes shaping the development proposals, while citizen engagement is a determining factor in shifting public discourse. Results show the need for collaborative governance structures across sectors, using intermediaries, to support a deeper understanding and integration of multiple perspectives in the shaping and negotiation of local sustainability discourses.
Paradigms and the research report: Making what actually happens a heuristic for theory
Authors: Trickett Edison J. 
Published: August 2022

ConclusionThe contention is that in providing an account of the intervention process beyond the usual parameters of reporting, Weinstein and her colleagues have helped bring to the fore issues in the conduct and reporting of intervention research which are anomalous to most current theories and accounts. Taken seriously, the issues openly discussed could provide a useful step toward reducing the discrepancy between how we carry out interventions and how we say we carry out interventions. Through attempts to incorporate these issues into theory, we increase the verisimilitude of our ideas and develop a more differentiated filter for our community work. If, as Cronbach asserts, “social science is cumulative, not in possessing ever‐more refined answers about fixed questions, but in possessing an ever‐richer repertoire of questions” (1986, p. 91), accounts such as those provided by Weinstein and her colleagues can indeed serve as a heuristic for theory by telling it like it was.