bluuebunny/crossref_metadata_2025_split huggingface dataset:
A sailing ship as a motif and symbol in The Life [Zhitie] of Archpriest Avvakum
Authors: Rostovtseva Yu. A. 
Published: November 2022

The article is concerned with the motif and symbol of a sailing ship in The Life [Zhitie] of Archpriest Avvakum. The researcher is the first to challenge the supposition about a ‘traditional’ genesis of this motif and symbol in Avvakum’s autobiography; she also defines the role of this motif in the plot of The Life — the magnum opus of the Old Believers’ spiritual leader. Various motif-related elements are ancillary to the main idea of The Life — to demonstrate the hero’s sainthood. The same message guides Avvakum’s choice of sources to borrow the main motif and symbol for his book. Among these is the medieval apocryphal tale Narration of Our Father Agapius [Skazanie otsa nashego Agapiya]. A comparison between the tale and Avvakum’s The Life confirms the hypothesis of such a borrowing, through which the motif and symbol of a sailing ship in the immolated archpriest’s autobiography translates into his guaranteed passage to the heavenly abode. In the closing paragraphs, the researcher shares her observations about the semantics of the motif and symbol of a ship in Avvakum’s prose works unrelated to The Life.
Mathematical Model of Armed Criminal Group with Pre-emitive and Repressive Intervention
Authors: Nur Wahyudin , Darmawati Darmawati 
Published: November 2022

Armed Criminal group is one of the problems faced by many countries in the world. Awful behaviour of armed criminal group members can affect a large amount of people. In this paper, we construct a deterministic mathematical model that takes into account persuasive and repressive intervention. We consider crime as a social epidemic. We determine the armed criminal group free equilibrium point and the armed criminal group persistence equilibrium point together with their existence condition. The next generation matrix is used to obtain the basic reproduction number. The local stability conditions of equilibrium points are proved using linearization. We show that the armed criminal group free equilibrium point is globally asymptotically stable under certain condition. Numerical simulations are performed to support our deductive study.
Architectural decoration of Christian churches of the Eastern Black Sea region between 10<sup>th</sup>-11<sup>th</sup> centuries. The decorative system: an attempt of reconstruction
Authors: Endoltseva E. Yu. , Bystritskiy N. I. 
Published: November 2022

Research of many years on the architectural decoration of Christian churches in Abkhazia and Southern Ossetia resulted in many important discoveries, which transpired crucial for the exact attribution of many artefacts. They also enabled the identification of some hitherto unsuspected research subjects. The findings helped to outline the 10th-11th cent. context for the architecture to be placed in both in the Byzantine Empire as well as neighbour countries. However, the lapidary collections that originate from Abkhazia and Southern Ossetia did not receive sufficient attention. Therefore, they invite a separate study on the functionality of their reliefs. This study would focus upon altar barriers fragments rather than the fragments, which constitute the facades of the Christian churches.Studying similar monuments, which originate from places (such as modern Georgia, Armenia, as well as historic Asia Minor and other parts of the then Byzantine Empire) is nowadays impossible without modern research methods and devices, in particular, those, which enable researchers to do the 3D reconstruction. Such reconstruction would help to visualize otherwise lost historically important monuments as well as forms of their decoration.Such researches would decisively contribute to the study of the artistic culture of these countries, especially in the late 9th-early 11th cent., when they began to consider themselves to be different from the Byzantine "metropole".Reconstruction of altar barriers and the facade decoration and identification of common typological features may clearly show the actual influence of these cultures on the development of Christian culture in Southern Caucasus. The Authors see the importance in showing the convergence between the cultures of the neighbouring areas in the Caucasus. The research necessity of this subject is already reflected in many works from Georgia, Russian Federation, France etc. Their results clearly show that small forms (10th-11th cent.) and façade decoration of the Christian churches in Abkhazia and Southern Ossetia have not yet received a systematic study, especially, because the research has been focused on the paleochristian period.Altogether, the lands of Western Georgia (passes between Karachay-Cherkessia, Kabardino-Balkaria, Abkhazia, Southern Ossetia and Racha) played a decisive role in the formation of the original type of medieval Christian self-conscience as reflected in art.
The role of radiation therapy in the treatment of spine metastases from hepatocellular carcinoma: a systematic review and meta-analysis
Authors: Ferini *Gianluca , Palmisciano Paolo , Scalia Gianluca , Haider Ali S , Bin-Alamer Othman , Sagoo Navraj S , Bozkurt Ismail , Deora Harsh , Priola Stefano M , Aoun Salah G , Umana Giuseppe E 
Published: November 2022

OBJECTIVE
Spine hepatocellular carcinoma (HCC) metastases severely worsen quality of life and prognosis, with the role of radiotherapy being controversial. The authors systematically reviewed the literature on radiotherapy for spine metastatic HCCs.

METHODS
The PubMed, Scopus, Web of Science, and Cochrane databases were searched according to the PRISMA guidelines to include studies of radiotherapy for spine metastatic HCCs. Outcomes, complications, and local control were analyzed with indirect random-effect meta-analyses.

RESULTS
The authors included 12 studies comprising 713 patients. The median time interval from diagnosis of HCC to spine metastases was 12 months (range 0–105 months). Most lesions were thoracic (35.9%) or lumbar (24.7%). Radiotherapy was delivered with conventional external-beam (67.3%) or stereotactic (31.7%) techniques. The median dose was 30.3 Gy (range 12.5–52 Gy) in a median of 5 fractions (range 1–20 fractions). The median biologically effective dose was 44.8 Gy10 (range 14.4–112.5 Gy10). Actuarial rates of postradiotherapy pain relief and radiological response were 87% (95% CI 84%–90%) and 70% (95% CI 65%–75%), respectively. Radiation-related adverse events and vertebral fractures had actuarial rates of 8% (95% CI 5%–11%) and 16% (95% CI 10%–23%), respectively, with fracture rates significantly higher after stereotactic radiotherapy (p = 0.033). Fifty-eight patients (27.6%) had local recurrences after a median of 6.8 months (range 0.1–59 months), with pooled local control rates of 61.6% at 6 months and 40.8% at 12 months, and there were no significant differences based on radiotherapy type (p = 0.068). The median survival was 6 months (range 0.1–62 months), with pooled rates of 52.5% at 6 months and 23.4% at 12 months.

CONCLUSIONS
Radiotherapy in spine metastatic HCCs shows favorable rates of pain relief, radiological responses, and local control. Rates of postradiotherapy vertebral fractures are higher after high-dose stereotactic radiotherapy.
Deformable medical image registration based on CNN
Authors: Yang Yunfeng , Wu Huihui 
Published: November 2022

Objective: This study aims to develop and test a new image registration method in which full-scale skip connections in the encoding process is added into the registration network, which can predict the deformation field more accurately by retaining more features and information in the decoding process. Methods: Two improved registration networks are connected in series in the registration framework. Each registration network uses the unsupervised learning registration method to predict a small deformation field, and the last two small deformation fields are superimposed to obtain the final deformation field. The model is evaluated by the oasis datasets (brain T1-weighted MRI images), one image is selected as the fixed image, while 383 images are used as training images and 30 images are used as test images. Wavelet decomposition and reconstruction are also used to enhance the image. Results: Compared with the affine method, the voxelmorph-1 method and the voxelmorph-2 method, applying the new registration network was proposed by this study improves the registration accuracy by 28.6%, 1.2% and 0.2%, respectively. Conclusion: The experimental results demonstrate that the method proposed in this study can improve the accuracy of image registration effectively.
PENGARUH PEMANFAATAN TEKNOLOGI DAN KEMAMPUAN TEKNIK PERSONAL TERHADAP EFEKTIVITAS SISTEM INFORMASI AKUNTANSI
Authors: Ramdah Nafa Nadiyah , Baining Mellya Embun , Khairiyani Khairiyani 
Published: November 2022

Tujuan Penelitian: Untuk mengetahui pengaruh pemanfaatan teknologi dan kemampuan teknik personal terhadap efektivitas sistem informasi akuntansi (studi empiris pada PT Djuanda sawit lestari musi rawas).
Desain/Metodologi/Pendekatan Penelitian: Metode yang digunakan adalah kuantitatif dengan analisis linier berganda, dengan uji T dan uji F yang berupa hasil jawaban responden, dan dinyatakan bentuk angka-angka diukur menggunakan statitsik SPSS 22, jumlah populasi 34 orang karyawan.
Hasil Penelitian: Hasil Penelitian Menunjukkan pengujian secara parsial dan simultan menunjukkan bahwa pemanfaatan teknologi dan kemampuan teknik personal berpengaruh positif dan signifikasi terhadap efektivitas sistem informasi akuntansi.
Implikasi Hasil Penelitian : Hasil penelitian ini memberi gambaran bahwa pemanfaatan teknologi bisa dikuasai dan digunakan oleh karyawan dengan sebaik-baiknya,agar penggunaan sistem informasi akuntansi berjalan dengan baik.
PENGARUH KONFLIK PERAN GANDA, STRESSOR PEKERJAAN DAN LINGKUNGAN KERJA TERHADAP KEPUASAN KERJA POLISI SATUAN RESERSE DAN KRIMINAL POLRES MERANGIN
Authors: Octodi Krisna Putra , Almasdi Almasdi 
Published: November 2022

Purpose: This study aims to examine the effect of (1) dual role conflict, Job stressors on police and The work environment on the job satisfaction of the police of the Merangin Police and Criminal Investigation Unit.
Design/methodology/approach: The population in this study were all 32 police officers from the Merangin Police and Criminal Investigation Unit. And the technique of determining the number of samples taken as respondents with this sampling technique using the total sampling technique (whole sample). The reason for taking total sampling is because according to the total population is less than 100, the entire population is used as a research sample .
Findings: The results of this study indicate that (1) dual role conflict has a negative effect on police job satisfaction at the Bukittinggi Police. (2) Job stressors have a negative effect on job satisfaction of the police of the Merangin Police and Criminal Investigation Unit. (3) The work environment has a positive influence on the job satisfaction of the Merangin Police Criminal and Investigation Unit. (4) Multiple role conflicts, stressors and the work environment together have a significant effect on police job satisfaction at the Merangin Police and Criminal Investigation Units.
Research implications: The results of this study are expected that by having high job satisfaction, the police can provide maximum service to the community, especially in the Merangin Police Criminal and Investigation Unit.
EFEKTIVITAS PENGGUNAAN LKPD MATEMATIKA BERBASIS REALISTIC MATHEMATICS EDUCATION TERHADAP HASIL BELAJAR PADA MATERI ARITMATIKA SOSIAL
Authors: Safitri Aulia , Yensy Nurul Astuty , Siagian Teddy Alfra 
Published: November 2022

Tujuan dari penelitian ini adalah menghasilkan LKPD berbasis Realistic Mathematic Education pada materi aritmatika sosial di SMP Negeri 11 Kota Bengkulu yang memenuhi kriteria valid, praktis, dan efektif. Penelitian ini adalah penelitian pengembangan dan menerapkan 4 tahapan dari model 4D, yaitu pendefinisian, perancangan, pengembangan dan penyebaran. Instrumen penelitian terdiri dari lembar validitas, lembar kepraktisan, dan tes hasil belajar. Hasil penelitian menunjukkan bahwa pengembangan LKPD berbasis RME memenuhi kriteria efektif dilihat dari ketuntasan belajar peserta didik secara klasikal memperoleh 82% peserta didik yang tuntas serta hasil perhitungan N gain tes hasil belajar dengan rata-rata N gain 0,78 berada pada kategori “tinggi” .
The efficacy of vancomycin-loaded biphasic calcium phosphate bone substitute in the promotion of new bone growth and the prevention of postoperative infection
Authors: Wang Shi-Yong , Yao Ru-Bin , Yang Kai-Shun , Liang Huang-Chien , Su Chen-Ying , Fang Hsu-Wei , Lim Sher-Wei 
Published: November 2022

Background: Due to the increasing need for suitable alternatives to bone grafts, artificial bones made of biphasic calcium phosphate (BCP) are currently being extensively researched. These porous bone substitutes have also demonstrated considerable incorporation with the host bone, and new bone is able to grow within the porous structure. They therefore offer a potential therapeutic approach for bone defects.Methods: Vancomycin-loaded Bicera™, a BCP bone substitute, was investigated in order to prevent implant-associated osteomyelitis and postoperative infection after orthopedic surgery. The loading capacity of Bicera™ was measured to understand its potential antibiotic adsorption volume. An antibiotic susceptibility test was also carried out to analyze the effect of Bicera™ loaded with different concentrations of vancomycin on the growth inhibition of methicillin-resistant Staphylococcus aureus (MRSA). Vancomycin-loaded Bicera™ was implanted into rabbits with bone defects, and general gross, radiographic, and histological evaluation was undertaken at 4, 12, and 24 weeks after implantation.Results: The maximum loading capacity of vancomycin-loaded Bicera™ was 0.9 ml of liquid regardless of the vancomycin concentration. Antibiotic susceptibility tests showed that vancomycin-loaded Bicera™ inhibited the growth of MRSA for 6 weeks. In addition, animal studies revealed that new bone grew into the vancomycin-loaded Bicera™. The percentage of new bone formation from 4 to 24 weeks after implantation increased from 17% to 36%.Conclusion: Vancomycin-loaded Bicera™ could effectively inhibit the growth of MRSA in vitro. It was found to incorporate into the host bone well, and new bone was able to grow within the bone substitute. The results of this study indicate that vancomycin-loaded Bicera™ is a potential bone substitute that can prevent implant-associated osteomyelitis and postoperative infection.
Sex related differences in the characteristics and outcomes of heart failure: A sub analysis of heart failure disease management study
Authors: Grupper Avishay , Freimark Dov , Murad Havi , Olmer Liraz , Benderly Michal , Ziv Arnona , Friedman Nurit , Kaufman Galit , Silber Haim , Kalter-Leibovici Ofra 
Published: November 2022

AimsThis is a sub-analysis of a randomized controlled trial on heart failure (HF) disease management (DM) in which patients with HF (N = 1,360; 27.5% women) were assigned randomly to DM (N = 682) or usual care (UC) (N = 678). Study intervention did not significantly affect the rate of hospital admissions or mortality. This study evaluates sex-related differences in baseline characteristics, clinical manifestations, adherence to treatment and outcomes among the study cohort.MethodsAssociation between sex and hospital admissions and mortality was tested in multivariable models adjusted for the patients’ baseline characteristics. The primary composite outcome of the study included time to first HF hospitalization or all-cause mortality. Secondary composite outcome included number of hospital admissions and days of hospitalization, for HF and all other causes.ResultsCompared to males, females recruited in the study were on average 3 years older [median age 72 (62, 78) vs. 75 (65, 82), p = 0.001], with higher prevalence of preserved left ventricular function (LVEF ≥50%) and lower frequency of ischemic heart disease (IHD) (p ≤ 0.001). Females had shorter 6-min walking distance and worse quality of life and depression scores at baseline (p &lt; 0.001). The proportion of patients receiving HF recommended medical treatment was similar among females and males. During a median follow-up of 2.7 years (range: 0–5), there were no significant differences between females and males with respect to the time elapsed until the study primary endpoint and its components in univariate analysis [557 (56.5%) males and 218 (58.3%) females were hospitalized for HF or died for any cause; p &gt; 0.05]. Multivariable analysis showed that females were significantly less likely than males to experience the primary outcome [adjusted hazard ratio (HR) = 0.835, 95% CI: 0.699, 0.998] or to die from any cause [adjusted HR = 0.712; 95%CI: 0.560, 0.901]. The sex-related mortality differences were especially significant among patients with non-preserved EF, with IHD or with recent HF hospitalization. Females also had lower rates of all-cause hospital admissions [adjusted rate ratio = 0.798; 95%CI: 0.705, 0.904] and were more likely to adhere to HF medical therapy compared to males.ConclusionFemales with HF fare better than men. Sex related differences were not explained by baseline and morbidity-related characteristics or adherence to medical treatment.
Epicardial adipose tissue is associated with left atrial volume and fibrosis in patients with atrial fibrillation
Authors: Chahine Yaacoub , Askari-Atapour Bahareh , Kwan Kirsten T. , Anderson Carter A. , Macheret Fima , Afroze Tanzina , Bifulco Savannah F. , Cham Matthew D. , Ordovas Karen , Boyle Patrick M. , Akoum Nazem 
Published: November 2022

BackgroundObesity is a risk factor for atrial fibrillation (AF) and strongly influences the response to treatment. Atrial fibrosis shows similar associations. Epicardial adipose tissue (EAT) may be a link between these associations. We sought to assess whether EAT is associated with body mass index (BMI), left atrial (LA) fibrosis and volume.MethodsLA fibrosis and EAT were assessed using late gadolinium enhancement, and Dixon MRI sequences, respectively. We derived 3D models incorporating fibrosis and EAT, then measured the distance of fibrotic and non-fibrotic areas to the nearest EAT to assess spatial colocalization.ResultsOne hundred and three AF patients (64% paroxysmal, 27% female) were analyzed. LA volume index was 54.9 (41.2, 69.7) mL/m2, LA EAT index was 17.4 (12.7, 22.9) mL/m2, and LA fibrosis was 17.1 (12.4, 23.1)%. LA EAT was significantly correlated with BMI (R = 0.557, p &lt; 0.001); as well as with LA volume and LA fibrosis after BSA adjustment (R = 0.579 and R = 0.432, respectively, p &lt; 0.001 for both). Multivariable analysis showed LA EAT to be independently associated with LA volume and fibrosis. 3D registration of fat and fibrosis around the LA showed no clear spatial overlap between EAT and fibrotic LA regions.ConclusionLA EAT is associated with obesity (BMI) as well as LA volume and fibrosis. Regions of LA EAT did not colocalize with fibrotic areas, suggesting a systemic or paracrine mechanism rather than EAT infiltration of fibrotic areas.
Osteoclast activity sculpts craniofacial form to permit sensorineural patterning in the zebrafish skull
Authors: Miao Kelly Z. , Cozzone Austin , Caetano-Lopes Joana , Harris Matthew P. , Fisher Shannon 
Published: November 2022

Efforts to understand the morphogenesis of complex craniofacial structures have largely focused on the role of chondrocytes and osteoblasts. Along with these bone–creating cells, bone–resorbing osteoclasts are critical in homeostasis of adult skeletal structures, but there is currently limited information on their role in the complex morphogenetic events of craniofacial development. Fundamental aspects of skull formation and general skeletal development are conserved from zebrafish to mammals. Using a cathepsinK reporter, we documented osteoclast location in the developing zebrafish skull over several weeks, from 5.18 mm to 9.6 mm standard length (approximately 15 to 34 days post fertilization). While broad distribution of osteoclasts is consistent across individuals, they are sparse and the exact locations vary among fish and across developmental time points. Interestingly, we observed osteoclasts concentrating at areas associated with neuromasts and their associated nerves, in particular the hyomandibular foramina and around the supraorbital lateral line. These are areas of active remodeling. In contrast, other areas of rapid bone growth, such as the osteogenic fronts of the frontal and parietal bones, show no particular concentration of osteoclasts, suggesting that they play a special role in shaping bone near neuromasts and nerves. In csf1ra mutants lacking functional osteoclasts, the morphology of the cranial bone was disrupted in both areas. The hyomandibular foramen is present in the initial cartilage template, but after the initiation of ossification, the diameter of the canal is significantly smaller in the absence of osteoclasts. The diameter of the supraorbital lateral line canals was also reduced in the mutants, as was the number of pores associated with neuromasts, which allow for the passage of associated nerves through the bone. Our findings define important and previously unappreciated roles for osteoclast activity in shaping craniofacial skeletal structures with a particular role in bone modeling around peripheral cranial nerves, providing a scaffold for wiring the sensioneural system during craniofacial development. This has important implications for the formation of the evolutionarily diverse lateral line system, as well understanding the mechanism of neurologic sequelae of congenital osteoclast dysfunction in human craniofacial development.