bluuebunny/crossref_metadata_2025_split huggingface dataset:
“What I share is not the same as therapy”: Psychologist experiences of Instagram use as a mental health influencer
Authors: White Ella , Hanley Terry 
Published: February 2025

AbstractIntroductionPsychologists are increasingly using social media to share their therapeutic knowledge. Despite this, social media guidelines devised by professional bodies remain limited in content, with the focus typically on personal use rather than professional use as a mental health influencer. Therefore, this study aimed to explore practitioner psychologists' experiences of Instagram use with an influencer presence.MethodsTwelve UK‐based practitioner psychologists were interviewed who had an Instagram account that they used as a mental health influencer. The semi‐structured interview transcripts were analysed using reflexive thematic analysis.ResultsThree themes were developed, each with four subthemes. The first theme ‘“I'm a psychologist, but I'm not your psychologist” explored psychologists’ experiences of trying to input boundaries on Instagram around self‐disclosure, risk management, time management, and client work. The second theme ‘“anxiety about not wanting to do the wrong thing” highlighted the impact of an influencer presence on psychologists’ own mental health. The third theme ‘“I share what I think is going to be helpful for other people and myself” considered the psychologists’ motivations for Instagram use for social justice advocacy and business promotion, and the contradictions between these.ConclusionPsychologists can use their training to share evidence‐based research as a free widely accessible form of psychoeducation potentially acting as a first step into therapy. However, there are still many ethical ambiguities thus updated guidance specifically for an influencer presence can reduce psychologists' anxieties and potential risks.
High nutrient requirement on the photosynthetic performance of a diatom species of the genus Nitzschia (Bacillariophyta) isolated from the high‐altitude wetland, Salar de Huasco, Chile
Authors: Eissler Yoanna , Anabalón Jeremy , Celis‐Plá Paula S. M. , Kieft Brandon , Junier Pilar , Rivera Patricio , Cruces Fabiola , Ascencio Enrique , Dorador Cristina , Molina Verónica 
Published: February 2025

SUMMARYThis study characterizes the ecophysiological responses and growth dynamics of Nitzschia palea isolated from Salar de Huasco, Chile, a high‐altitude wetland located at 3800 m above sea level. The culture was maintained at 17°C under cool‐white fluorescent light with a 14:10 h light/dark photocycle and a photon flux of 50 μmol photons m−2 s−1. The diatom was identified morphologically and genetically, with phylogenetic analysis confirming its close relationship to known N. palea strains. Photophysiological responses were measured along with a series of media and temperature conditions in N. palea strain. Modified f/2 media supplemented with different concentrations of Si, Se and vitamins were tested. Subsequently, growth in the double‐Si f/2 media was assessed at three different temperatures. Lastly, the diatom strain was incubated at 17°C and 27–29°C in f/2 + double‐Si (NN: non‐extra nutrient addition) and a highly eutrophic state of f/2 (WN: with nutrient enrichment addition). The highest growth was observed using the f/2 media WN at 17°C (day 5, 4.46 × 105 ± 3.15 × 104 SD cells mL−1). Temperature significantly influenced growth; 17°C supported higher cell densities and more stable photosynthetic parameters compared 27–29°C. Nutrient enrichment further enhanced photosynthetic efficiency (αETR) and maximal quantum yield (Fv/Fm), particularly under control temperature conditions. Photosynthetic performance, assessed via rapid light‐response curves, showed significant temperature and nutrient dependent variation. Nitzschia palea cultures at 27–29°C exhibited increased in relative maximal ETR (rETRmax,184.1 μmol m−2 s−1) compared to control conditions. In nutrient enriched treatments, photosynthetic efficiency peaked on day 5, but declined by day 8. These findings highlight the adaptive capacity of N. palea to fluctuating environmental conditions and underscore its potential as a model organism for studying diatom responses to nutrient and temperature stress in extreme ecosystems.
Is Self‐Report of Attachment Patterns in Young People Stable From Three to Nine Months After a Concussion?
Authors: Tuborgh Astrid , Svendsen Susanne Wulff , Elklit Ask , Hunter Jon , Jensen Jens Søndergaard , Ørnbøl Eva , Schröder Andreas , Nielsen Jørgen Feldbæk , Thastum Mille Møller , Næss‐Schmidt Erhard Trillingsgaard , Rask Charlotte Ulrikka 
Published: February 2025

ABSTRACTInsecure adult attachment patterns have recently been associated with an increased risk of developing persistent post‐concussion symptoms (PCS) and poorer treatment outcomes, highlighting the potential of attachment‐informed treatment protocols for persistent PCS. A key requirement for such approaches is that attachment patterns remain relatively stable during the post‐injury illness course, allowing them to serve as reliable indicators for guiding initial care and treatment planning. This study aimed to assess the stability of self‐reported attachment anxiety and attachment avoidance in individuals aged 15–30 years, from three (T1) to nine (T2) months after a concussion, corresponding to the period when treatment for PCS typically becomes relevant. This study is a methodological follow‐up of a larger clinical cohort study comprising 3080 individuals aged 15–30 years who were diagnosed with a concussion. Attachment dimensions were measured using the Experiences in Close Relationships‐Relationship Structures Questionnaire at three (T1) and nine (T2) months post‐injury. Both mean‐level and individual changes were examined, taking relevant covariates such as sex, age, level of PCS, post‐traumatic stress disorder symptoms, and social support into account. At T1, 958 respondents were included (39%), with 416 also responding at T2 (43%). Mean‐level changes were minimal (attachment anxiety: β = −0.07 (95% confidence interval [CI]: −0.22; 0.08)), attachment avoidance: β = 0.00 (95% CI: −0.11; 0.11). Larger individual changes that could not be explained by measurement error were observed in 12% of participants. No association was found with any of the covariates. Self‐reported attachment patterns appear to remain stable in most young people with a concussion from 3 to 9 months post‐injury. The findings strengthen confidence in conducting research to investigate whether attachment‐informed treatment approaches can improve healthcare for these patients.
How Institutional Layering Shapes Collaborative Governance: An Examination of Forest Collaboratives in the Pacific Northwest (PNW)
Authors: Dill Brian 
Published: February 2025

ABSTRACTCollaborative governance arrangements have become an important means by which a wide range of complex collective action problems are solved. Despite the importance assigned by many scholars and policy makers to the role of collaboration, the matter of how these new institutions emerge and take form has not received the consideration it warrants. In the prevailing view, institutional innovations emerge when state actors are confronted with complex problems that exceed the limits of traditional administrative structures and jurisdictional boundaries. Existing rules are seemingly “displaced'' to allow for the introduction of new ones. This article explores the question of what happens when collaborative governance arrangements have been “layered” on top of preexisting institutions to convert them toward new objectives. Using forest collaboratives engaged in managing federal public lands in the Pacific Northwest as a case study, I argue that layering collaborative requirements on top of an existing institutional apparatus may not be the best way to put a bureaucracy in the service of new goals. I propose restructuring or replacing outdated frameworks to create a more integrated system that fosters genuine collaboration, aligns with current goals, and effectively addresses complex challenges.
Design of a 6-DOF Heavy-Duty and High-Precision 3-3 Orthogonal Parallel Robot with Flexible Hinges
Authors: Qi Chenkun , Lin Jianfeng , Hu Yan , Zhou Songlin , Gao Feng 
Published: February 2025

Abstract
Parallel robot is important in high-precision application. The current studies focus on the high-precision robot with light payload capability. It is insufficient for the supporting of space optical telescope. When designing a robot with large payload, performance redundancy of the robot needs to be reduced because the high payload and precision will cause high cost. In this paper, a 6-DOF heavy-duty and high-precision 3-3 orthogonal parallel robot with flexible hinges is presented. A performance redundance minimization-based type selection method is proposed by the isotropy comparison. The performance of between Stewart and orthogonal mechanisms is compared based on local transmission index, force and torque payload isotropy, displacement and rotation accuracy isotropy. A performance mean maximization and standard deviation minimum dimensional optimization method is proposed. Two new indexes named payload distribution index and accuracy distribution index are proposed to evaluate the performance redundancy of the mechanism. The mechanism parameters are designed based on performance atlas using workspace volume index, global transmission index, global payload index, global accuracy index, payload distribution index, and accuracy distribution index. A new modeling method considering the nun-functional motion of spherical joint with stiffness compensation is proposed. Modeling and control experiments on the robot demonstrate the effectiveness of the proposed method.
Comparative Analysis of U17, U20, and Senior Football Team Performances in the FIFA World Cup: From Youth to Senior Level
Authors: Ju Wonwoo , Morgans Ryland , Webb Jordan , Cost Rick , Oliva-Lozano José M. 
Published: February 2025

Purpose: This study aimed to investigate differences in match physical and technical/tactical performance of teams across different competitive levels in international soccer: FIFA Men’s World Cup Qatar 2022 (MWC), FIFA U20 World Cup Argentina 2023 (U20WC), and FIFA U17 World Cup Indonesia 2023 (U17WC). Methods: From a total of 168 games, 138 games were analyzed (N = 276 game observations) using an optical tracking system. Results: On average, the U17WC teams exhibited reduced total running (3% less), high-intensity running (14%–16% less), and sprinting (18%–26% less) distance than the MWC and U20WC teams (P ≤ .0023; effect size [ES]: 0.8–1.5). The MWC teams displayed 4% to 5% higher accuracy in passing and executing line breaks (P ≤ .0188; ES: 0.6–0.7), along with increased offers to receive the ball (53%–118% more) and movements to receive the ball (44%–101% more), and received the ball (61%–137%) more often than the U20WC and U17WC teams (P < .001; ES: 1.1–2.1). Moreover, notable decreases in defensive pressure (−18% to −32%) and forced turnovers (−26% to −32%) were observed in the U17WC than other competitions (P ≤ .0001; ES: 0.8–2.2). Greater variability was observed among the U17WC teams in several metrics, including high-intensity/sprinting distances, attempts at goal, and receptions in the final third. Conclusions: These findings demonstrate that as the competitive level increases, so do the physical demands, advanced technical skills, and tactical fluidity/adaptability. However, caution should be exercised when interpreting match performance of younger age groups, as higher variability was evident in both physical and technical/tactical performance in matches.
Sarcopenia-Related Parameters in Older Adults With End-Stage Renal Disease: A Case-Control Study
Authors: Arcila Castaño Luz A. , Vilas-Boas Vanessa Fonseca , De Lima Vivian Castillo , Coelho-Júnior Hélio J. , Uchida Marco C. 
Published: February 2025

Objective: Examine the impact of hemodialysis therapy on physical function and body composition after 6 months in community-dwelling older adults with and without chronic kidney disease (CKD). Methods: A case-control study was conducted to assess physical function in older adults on hemodialysis therapy (hemodialysis-dependent CHD patients [HD]) compared with robust older adults without CKD. The study included 23 HD patients (68.8 ± 5.2 years) and 25 control group participants (68.1 ± 6.3 years). Physical function and body composition were evaluated using standard tests and bioelectrical impedance analysis, respectively. Results: Significant differences (p < .05) in physical function were observed between the groups. The HD group showed markedly slower performance in usual gait speed (38.46% slower), five times sit-to-stand test (104.08% slower), Timed Up and Go test (68.65% slower), Timed Up and Go cognitive (142.30% slower), and one-leg stand balance test on the right leg (52.85% lower). However, there were no significant differences in appendicular skeletal mass muscle and fat mass between the HD and control groups. However, lean mass muscle showed the significant reduction for male CKD patients. Conclusion: Hemodialysis therapy significantly reduces physical function in community-dwelling older adults with CKD, with a high prevalence of mobility impairments observed 6 months after initiating dialysis therapy. Conversely, only lean mass muscle was reduced significantly for male patients. Significance: This study highlights the critical need for targeted interventions to counteract the accelerated decline in physical function and lean muscle mass in older adults with CKD undergoing hemodialysis.
Health impacts of the Sure Start programme on disadvantaged children in the UK: a systematic review
Authors: Hayre Jatinder , Pearce Helen , Khera Raj , Lunn Amy Dehn , Ford John Alexander 
Published: February 2025

ObjectivesWith rising poverty and widening health inequity among children in the UK, the objective of this study is to evaluate the impact of the Sure Start programme on child health outcomes in disadvantaged children.DesignSystematic review.Data sourcesWe conducted a comprehensive search of three databases: Embase, Medline and Social Policy and Practice, with grey literature searched using Open Grey, Social Care Online and Google Scholar. The search was conducted in January 2024.Eligibility criteria for selecting studiesAll primary studies investigating health outcomes in children as a result of Sure Start intervention were eligible for inclusion, without limitations on study design.Data extraction and synthesisFull-text articles in English were independently screened according to the eligibility criteria by two researchers. Results were synthesised and presented in both a quantitative and narrative format. We assessed the risk of bias in each included study.ResultsOur initial search identified 585 records, of which 9 met our inclusion criteria with a further 3 grey literature reports included. Three themes were identified: physical health, social functioning and neurodevelopmental disorders. In terms of physical health, our findings indicate significant reductions in hospitalisations in older children, accidental injury and obesity prevalence. Furthermore, Sure Start increased the prevalence of breastfeeding and improved dental hygiene in children. In the social functioning domain, the Sure Start programme produced mixed findings: with children from certain backgrounds observing adverse effects as a result of the intervention. Yet, Sure Start demonstrated significant improvement in education attainment, with a maximal improvement of grade improvement in children from low socio-economic and ethnic minority backgrounds. For neurodevelopmental disorders, Sure Start was able to significantly improve conduct disorder and attention-deficit hyperactivity disorder symptomatology with long-term clinical stabilisation, as well as improving screening rates for developmental disorders.ConclusionThis study examines the evidence of the Sure Start programme, as an example of an early-years community-based intervention, to mitigate health inequity among disadvantaged children. The findings suggest the Sure Start programme to be effective in health generation across the domains of physical health and neurodevelopmental disorders for disadvantaged children, but with mixed findings for social development that can only partially be explained by methodological flaws.Trial registration numberPROSPERO CRD42024503234.
Corticosteroid premedication on anti-tumor effect of immune checkpoint blockade in murine hepatocellular carcinoma models
Authors: Shen Ying-Chun , Chang Nai-Wen , Yeh Ching-Ping , Lin Wan-Ying , Wei Ming-Feng , Ou Da-Liang , Hsu Chia-Lang , Cheng Ann-Lii 
Published: February 2025

Background and aimsCorticosteroid is effective in alleviating immune-related adverse events (irAEs) of immune checkpoint blockade (ICB). However, prophylactic use of corticosteroid to prevent irAEs is not recommended due to a looming concern that it may attenuate anti-tumor effect of ICB. This study aims to investigate whether corticosteroid premedication may compromise anti-tumor efficacy of dual ICB, a regimen that may cause significant irAEs.MethodsOrthotopic BNL 1MEA.7R.1 and subcutaneous Hepa1-6 syngeneic hepatocellular carcinoma (HCC) models were used. Low-dose (LD; 10 µg) or high-dose (HD; 200 µg) dexamethasone (Dexa) was intraperitoneally administered before each dose of anti-CTLA-4 and anti-PD-1. Tumor shrinkage, T cell priming, cytokine quantitation, as well as cytotoxicity and single-cell RNA-sequencing (scRNA-seq) of tumor-infiltrating T cells were assessed.ResultsIn the orthotopic model, dual immune checkpoint blockade (dICB) plus phosphate buffered saline (PBS) significantly reduced the mean tumor weight (adjusted for SE) (0.73±0.18 g vs 2.45±0.54 g; p=0.03), while neither LD nor HD Dexa premedication affected dICB-induced tumor shrinkage. In the subcutaneous model, dICB plus PBS or LD Dexa yielded a complete tumor response (CR) rate of 100%, while dICB plus HD Dexa yielded a CR rate of 85.7% (p>0.05, comparing to dICB plus PBS). ScRNA-seq analysis demonstrates that Dexa did not affect dICB-induced reduction of major clusters of exhausted CD4+ and CD8+ T cells but halved dICB-induced expansion of effector memory CD8+ T cells. Nevertheless, Dexa premedication, regardless of dosage, did not diminish dICB-induced T cell priming, cytokine production, or cytotoxicity of tumor-infiltrating CD8+ T cells.ConclusionCorticosteroid premedication does not significantly compromise anti-tumor efficacy of dICB treatment in murine HCC models. These results suggest that clinical investigations of prophylactic corticosteroids to alleviate severe irAEs may be feasible.
Sexual experience and functioning in male and female patients with Sjögren’s disease: a qualitative study
Authors: Rebel Dagmar , Paap Davy , Arends Suzanne , Kroese Frans , Pool Grieteke , Bootsma Hendrika 
Published: February 2025

ObjectiveSjögren’s disease (SjD) can have a major impact on sexual functioning, but this topic has received limited attention in research and clinical practice. This qualitative study investigated how SjD affects sexual experience and functioning in both women and men.MethodReflexive thematic analysis was performed based on in-depth interviews with patients with SjD. Sexual functioning was measured using the Female Sexual Function Index and International Index of Erectile Function questionnaire.Results11 female and 9 male patients with SjD, aged between 24 and 65 years, were included. According to questionnaire scores, 64% of female and 67% of male participants reported sexual dysfunction. In both sexes, six themes were identified as important in sexual experience and functioning: chronic stress in life, symptoms of SjD (affecting sexual experience), invisible suffering of SjD, impact of illness perception on coping strategies for sexuality-related symptoms, quality of (sexual) partner relationship and taboo of sexuality. These themes interact with each other and together shape the sexual experience.ConclusionSjD plays a crucial role in the quality of sexual experience. Many participants reported an unmet need for support, advice and treatment of sexuality-related symptoms related to SjD. The themes generated provide valuable insights into understanding the factors that shape sexual experience and underscore the importance of addressing sexuality-related symptoms as part of holistic care for patients with SjD. Due to the complexity of sexual experience and functioning, future research should focus on the patient as a whole person, and not solely on physical sexual functions.
Electrochemical Sensors Based on Schiff Base to Detect Pb(II) ion: Recent Advancements and Future Perspectives
Authors: Srivastva Abhay Nanda , Milan Kriti , Singh Dharm Veer , Afzal Mohd , Singh Netra Pal , Chaudhary Vishal , Kumar Manish 
Published: February 2025

Abstract
Schiff base has gained attention being highly sensitive towards metal ions. Lead, one among the heavy metals, is harmful for the human health along with the environment. Lead contamination is a matter of concern across the globe. Hazardous effects of lead can be minimized by detecting its presence in food and water. Detection of lead ion by electrochemical sensors is gaining credence in which Schiff base is extolled as being highly selective, cost effective and rapid sensitive towards Pb(II). The Schiff base sensor provides a generous pathway to extricate the dolorous effects of lead by early detection.
Validation of a digital pathology-based multimodal artificial intelligence biomarker in a prospective, real-world prostate cancer cohort treated with prostatectomy
Authors: Bjartell Anders , Krzyzanowska Agnieszka , Liu Vinnie Y.T. , Tierney Meghan , Royce Trevor J. , Sjöström Martin , Palominos-Rivera Marisol Macarena , Chen Emmalyn , Kraft Alexandra , Esteva Andre , Feng Felix Y. 
Published: February 2025

Abstract
Purpose: A multimodal artificial intelligence (MMAI) biomarker was developed using clinical trial data from North American men with localized prostate cancer (PCa) treated with definitive radiation, using biopsy digital pathology images and key clinical information (age, PSA, T-stage) to generate prognostic scores. This study externally validates the biomarker in a prospective, real-world dataset of men who underwent radical prostatectomy (RP) for localized PCa at a tertiary referral center in Sweden. Experimental Design: Association between the MMAI scores (continuously and categorically) and endpoints of interest were performed with Fine-Gray and cumulative incidence analyses for biochemical recurrence (BCR) and logistic regression for adverse pathology (AP) at RP. Results: The analysis included 143 patients with evaluable biopsy pathology images and complete clinical data to generate MMAI scores. Median follow-up was 8.8 years. At diagnosis, median PSA was 7.5 ng/mL, median age 64 years, 29% had Gleason grade group ≥3, and 88 men were evaluable for AP at RP. MMAI was significantly associated with BCR (subdistribution HR 2.45 [95% CI 1.77-3.38], p&lt;0.001) and AP at RP (OR 4.85 [95% CI 2.54-10.78], p&lt;0.001). Estimated 5-yr BCR rates for MMAI Intermediate-High vs Low were 25% (95% CI 16%-36%) vs 4% (95% CI 1%-11%), respectively. Conclusions: The MMAI biomarker, previously shown to be prognostic for distant metastasis and prostate cancer-specific mortality in men receiving definitive radiation, was prognostic for post-RP endpoints: BCR and AP. This biomarker validation study further supports the use of MMAI biomarkers in men with PCa outside North America and those treated with RP.