bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coincident Biogenic Nitrite and pH Maxima Arise in the Upper Anoxic Layer in the Eastern Tropical North Pacific
Authors: Cinay Timur , Dumit Diana , Woosley Ryan J. , Boles Elisabeth L. , Kwiecinski Jarek V. , Mullen Susan , Tamasi Tyler J. , Wolf Martin J. , Kelly Colette L. , Travis Nicole M. , Casciotti Karen L. , Babbin Andrew R. 
Published: December 2022

AbstractThe Eastern Tropical North Pacific (ETNP), like the other marine oxygen deficient zones (ODZs), is characterized by an anoxic water column, nitrite accumulation at the anoxic core, and fixed nitrogen loss via nitrite reduction to N2O and N2 gases. Here, we constrain the relative contribution of biogeochemical processes to observable features such as the secondary nitrite maximum (SNM) and local pH maximum by simultaneous measurement of inorganic nitrogen and carbon species. High‐resolution sampling within the top 1 km of the water column reveals consistent chemical features previously unobserved in the region, including a tertiary nitrite maximum. Dissolved inorganic carbon measurements show that pH increases with depth at the top of the ODZ, peaking at the potential density of the SNM at σθ = 26.15 ± 0.06 (1 s.d.). We developed a novel method to determine the relative contributions of anaerobic ammonium oxidation (anammox), denitrification, nitrite oxidation, dissimilatory nitrate reduction to nitrite, and calcium carbonate dissolution to the nitrite cycling in the anoxic ODZ core. The calculated relative contributions of each reaction are slightly sensitive to the assumed C:N:P ratio and the carbon oxidation state of the organic matter sinking through the ODZ. Furthermore, we identify the source of the pH increase at the top of ODZ as the net consumption of protons via nitrite reduction to N2 by the denitrification process. The increase in pH due to denitrification impacts the buffering effect of calcite and aragonite dissolving in the ETNP.
Retrieval of a Real‐Time Sea Surface Vector Field From SAR Doppler Centroid: 1. Ekman Current Retrieval
Authors: Yang Xiaobo , He Yijun 
Published: December 2022

AbstractCurrent direction retrieval is a significant part of the Doppler Centroid Technique (DCT) for remote sensing of the sea surface vector field, and it remains an unsolved problem that has prevented its wide application for more than 15 years. In this paper, we review and update the core concept of the DCT, through which the Ekman scheme for current direction retrieval is obtained. In addition, the real sea surface vector field at approximately 24°N with weak background flow during Hurricane Sam is retrieved. We also prove that the measured velocity of the DCT is just the magnitude of the sea surface current vector, and thus, the DCT is the most promising technique for remote sensing of sea surface current dynamics.
Rapid Surface Warming of the Pacific Asian Marginal Seas Since the Late 1990s
Authors: Wang You‐Lin , Wu Chau‐Ron 
Published: December 2022

AbstractThe East Asian marginal seas gain heat from the warm pool via intrusion of the Kuroshio Current and play an important role in regulating regional climate. Here, we show that the sea surface temperature rise of the East Asian marginal seas, especially in areas where the Kuroshio intrudes, has far exceeded the rate of global ocean warming. We attribute this to warming of the Pacific Warm Pool since the 1990s. Intensified trade winds warmed the Pacific Warm Pool and caused the surface Kuroshio and the regions where it intrudes into marginal seas to warm rapidly in the late 1990s.
Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants
Authors: Hu He-Ying , Zhang Ya-Ru , Aerqin Qiaolifan , Ou Ya-Nan , Wang Zuo-Teng , Cheng Wei , Feng Jian-Feng , Tan Lan , Yu Jin-Tai 
Published: December 2022

AbstractMultimorbidity (the presence of two or more long-term conditions [LTCs]) was suggested to exacerbate the neuronal injuries. The impact of multimorbidity on dementia has not been fully elucidated. We aimed to investigate the association between multimorbidity and dementia risk. We used the prospective data from 245,483 UK Biobank participants during a 9-year follow-up. Multimorbidity status was evaluated based on the LTC counts and multimorbidity patterns. Cox regression models adjusted for potential confounders were used to examine the associations of multimorbidity status with all-cause dementia (ACD), Alzheimer’s disease (AD) and vascular dementia (VD). Participants with multimorbidity at baseline had higher risks of ACD and VD, and the risks were elevated with the increase of LTC counts (ACD: hazard ratios [HR] = 1.15, 95% confidence intervals [CI] = 1.01–1.31 with 2 LTCs; HR = 1.18, CI = 1.01–1.39 with 3 LTCs; HR = 1.65, CI = 1.44–1.88 with ≥4 LTCs; VD: HR = 1. 66, CI = 1.24–2.21 with 2 LTCs; HR = 2.10, CI = 1.53–2.88 with 3 LTCs; HR = 3.17, CI = 2.43–4.13 with ≥4 LTCs). Participants with ≥4 LTCs also had a higher risk of AD (HR = 1.34, CI = 1.08–1.66]. Participants with the cardio-cerebrovascular/respiratory/metabolic/musculoskeletal/depressive multimorbidity were 1.46, 1.28, and 2.50 times more likely to develop ACD (HR = 1.46, 95% CI = 1.28–1.67), AD (HR = 1.28, CI = 1.04–1.58), and VD (HR = 2.50, CI = 1.90–3.27), respectively. Those with tumor/genitourinary/digestive disorders had a 11% higher hazard of ACD (HR = 1.11, CI = 1.00–1.24) and a 73% elevated risk of VD (HR = 1.73, CI = 1.37–2.18). The prevention of LTC accumulation and the identification of specific multimorbidity patterns might be beneficial to the prevention of dementia and its subtypes, AD as well as VD.
CD1a promotes systemic manifestations of skin inflammation
Authors: Hardman Clare S. , Chen Yi-Ling , Wegrecki Marcin , Ng Soo Weei , Murren Robert , Mangat Davinderpreet , Silva John-Paul , Munro Rebecca , Chan Win Yan , O’Dowd Victoria , Doyle Carl , Mori Prashant , Popplewell Andy , Rossjohn Jamie , Lightwood Daniel , Ogg Graham S. 
Published: December 2022

AbstractInflammatory skin conditions are increasingly recognised as being associated with systemic inflammation. The mechanisms connecting the cutaneous and systemic disease are not well understood. CD1a is a virtually monomorphic major histocompatibility complex (MHC) class I-like molecule, highly expressed by skin and mucosal Langerhans cells, and presents lipid antigens to T-cells. Here we show an important role for CD1a in linking cutaneous and systemic inflammation in two experimental disease models. In human CD1a transgenic mice, the toll-like receptor (TLR)7 agonist imiquimod induces more pronounced splenomegaly, expansion of the peripheral blood and spleen T cell compartments, and enhanced neutrophil and eosinophil responses compared to the wild-type, accompanied by elevated skin and plasma cytokine levels, including IL-23, IL-1α, IL-1β, MCP-1 and IL-17A. Similar systemic escalation is shown in MC903-induced skin inflammation. The exacerbated inflammation could be counter-acted by CD1a-blocking antibodies, developed and screened in our laboratories. The beneficial effect is epitope dependent, and we further characterise the five best-performing antibodies for their capacity to modulate CD1a-expressing cells and ameliorate CD1a-dependent systemic inflammatory responses. In summary, we show that a therapeutically targetable CD1a-dependent pathway may play a role in the systemic spread of cutaneous inflammation.
GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression
Authors: Zhao Ya-Nan , Jiang Jian-Bo , Tao Shi-Yuan , Zhang Yang , Chen Ze-Ka , Qu Wei-Min , Huang Zhi-Li , Yang Su-Rong 
Published: December 2022

AbstractRapid eye movement (REM) sleep disturbances are prevalent in various psychiatric disorders. However, the neural circuits that regulate REM sleep remain poorly understood. Here, we found that in male mice, optogenetic activation of rostromedial tegmental nucleus (RMTg) GABAergic neurons immediately converted REM sleep to arousal and then initiated non-REM (NREM) sleep. Conversely, laser-mediated inactivation completely converted NREM to REM sleep and prolonged REM sleep duration. The activity of RMTg GABAergic neurons increased to a high discharge level at the termination of REM sleep. RMTg GABAergic neurons directly converted REM sleep to wakefulness and NREM sleep via inhibitory projections to the laterodorsal tegmentum (LDT) and lateral hypothalamus (LH), respectively. Furthermore, LDT glutamatergic neurons were responsible for the REM sleep-wake transitions following photostimulation of the RMTgGABA-LDT circuit. Thus, RMTg GABAergic neurons are essential for suppressing the induction and maintenance of REM sleep.
Observation of full-parameter Jones matrix in bilayer metasurface
Authors: Bao Yanjun , Nan Fan , Yan Jiahao , Yang Xianguang , Qiu Cheng-Wei , Li Baojun 
Published: December 2022

AbstractMetasurfaces, artificial 2D structures, have been widely used for the design of various functionalities in optics. Jones matrix, a 2×2 matrix with eight parameters, provides the most complete characterization of the metasurface structures in linear optics, and the number of free parameters (i.e., degrees of freedom, DOFs) in the Jones matrix determines the limit to what functionalities we can realize. Great efforts have been made to continuously expand the number of DOFs, and a maximal number of six has been achieved recently. However, the realization of the ultimate goal with eight DOFs (full free parameters) has been proven as a great challenge so far. Here, we show that by cascading two layer metasurfaces and utilizing the gradient descent optimization algorithm, a spatially varying Jones matrix with eight DOFs is constructed and verified numerically and experimentally in optical frequencies. Such ultimate control unlocks opportunities to design optical functionalities that are unattainable with previously known methodologies and may find wide potential applications in optical fields.
The endocast of the insular and extinct Sylviornis neocaledoniae (Aves, Galliformes), reveals insights into its sensory specializations and its twilight ecology
Authors: Riamon Ségolène , Balouet Jean-Christophe , Rolland-Guillard Jeanne , Salaviale Céline , Guenser Pauline , Steyer Jean-Sébastien , Louchart Antoine 
Published: December 2022

AbstractSylviornis neocaledoniae (Galliformes, Sylviornithidae), a recently extinct bird of New-Caledonia (Galliformes, Sylviornithidae) is the largest galliform that ever lived and one of the most enigmatic birds in the world. Herein, for the first time, we analyze its neuroanatomy that sheds light on its lifestyle, its brain shape and patterns being correlated to neurological functions. Using morphometric methods, we quantified the endocranial morphology of S. neocaledoniae and compared it with extinct and extant birds in order to obtain ecological and behavioral information about fossil birds. Sylviornis neocaledoniae exhibited reduced optic lobes, a condition also observed in nocturnal taxa endemic to predator-depauperate islands, such as Elephant birds. Functional interpretations suggest that S. neocaledoniae possessed a well-developed somatosensorial system and a good sense of smell in addition to its specialized visual ability for low light conditions, presumably for locating its food. We interpret these results as evidence for a crepuscular lifestyle in S. neocaledoniae.
Early warning and diagnostic visualization of Sclerotinia infected tomato based on hyperspectral imaging
Authors: Zhou Yongxin , Chen Jiaze , Ma Jinfang , Han Xueqin , Chen Bijuan , Li Guilian , Xiong Zheng , Huang Furong 
Published: December 2022

AbstractThis research explored the feasibility of early warning and diagnostic visualization of Sclerotinia infected tomato by using hyperspectral imaging technology. Healthy tomato plants and tomato plants with Sclerotinia sclerotiorum were cultivated, and hyperspectral images at 400–1000 nm were collected from healthy and infected tomato leaves at 1, 3, 5, and 7 days of incubation. After preprocessing the spectra with first derivative (FD), second derivative (SD), standard normal variant (SNV), and multiplicative scatter correction (MSC) partial least squares discriminant analysis (PLS-DA) and support vector machine (SVM) were used to construct tomato sclerotinia identification model and select the best preprocessing method. On this basis, two band screening methods, competitive adaptive reweighted sampling (CARS) and successive projections algorithm (SPA), were introduced to reduce data redundancy and improve the model’s prediction accuracy. The results showed that the accuracy of the validation sets and operation speed of the CARS-PLS and CARS-SVM models were 87.88% and 1.8 s, and 87.95% and 1.78 s, respectively. The experiment was based on the SNV-CARS-SVM prediction model combined with image processing, spectral extraction, and visualization analysis methods to create diagnostic visualization software, which opens a new avenue to the implementation of online monitoring and early warning system for sclerotinia infected tomato.
Possible contribution of COVID-19 vaccination to the subsequent mental well-being in Japan
Authors: Chiang Chifa , Morita Shuhei , Hirakawa Yoshihisa , Priya Farzana Tanzin , Matsumoto Yuka , Ota Atsuhiko , Yatsuya Hiroshi , Tabuchi Takahiro 
Published: December 2022

AbstractThe coronavirus disease 2019 (COVID-19) pandemic has had a severe impact on mental well-being. Vaccination may have played a pivotal role in enduring this mental health crisis. The present study aimed to longitudinally investigate the association between COVID-19 vaccination and mental health status among Japanese population in 2021. Longitudinal data of 17,089 individuals aged 15–79 years who participated in a nationwide online study were analyzed. Baseline and follow-up mental health statuses were assessed using the Kessler Psychological Distress Scale (K6). General linear and multivariable logistic regression models adjusted for baseline levels of mental distress were used to examine the association between vaccine receipt and follow-up levels of mental health. Mean K6 scores were lower in the vaccinated than in the non-vaccinated participants. Those who had received one or two doses of COVID-19 vaccines were associated with improved mental health at follow-up in subjects with psychological distress at baseline (odds ratio [OR] 1.31 and 1.35, respectively) and were inversely associated with deteriorated mental health status at follow-up in subjects without psychological distress at baseline (OR 0.66 and 0.70, respectively) compared with no vaccination groups, respectively. The present study would indicate that one or two doses of COVID-19 vaccinations contributed to mental well-being in Japan. This finding might provide evidence for promoting vaccination against COVID-19 and emerging infectious diseases in the future.
Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes
Authors: Bartuzi Damian , Kędzierska Ewa , Targowska-Duda Katarzyna M. , Koszła Oliwia , Wróbel Tomasz M. , Jademyr Simon , Karcz Tadeusz , Szczepańska Katarzyna , Stępnicki Piotr , Wronikowska-Denysiuk Olga , Biała Grażyna , Handzlik Jadwiga , Kristensen Jesper L. , Poso Antti , Kaczor Agnieszka A. 
Published: December 2022

AbstractAnxiety is a troublesome symptom for many patients, especially those suffering from schizophrenia. Its regulation involves serotonin receptors, targeted e.g. by antipsychotics or psychedelics such as LSD. 5-HT2A receptors are known for an extremely long LSD residence time, enabling minute doses to exert a long-lasting effect. In this work, we explore the changes in anxiety-like processes induced by the previously reported antipsychotic, D2AAK1. In vivo studies revealed that the effect of D2AAK1 on the anxiety is mediated through serotonin 5-HT1A and 5-HT2A receptors, and that it is time-dependent (anxiogenic after 30 min, anxiolytic after 60 min) and dose-dependent. The funnel metadynamics simulations suggest complicated ligand-5HT2AR interactions, involving an allosteric site located under the third extracellular loop, which is a possible explanation of the time-dependency. The binding of D2AAK1 at the allosteric site results in a broader opening of the extracellular receptor entry, possibly altering the binding kinetics of orthosteric ligands.
Diagnostic delay in children with inflammatory bowel disease in the German-Austrian patient registry CEDATA-GPGE 2014–2018
Authors: Leiz Maren , Knorr Melanie , Moon Kilson , Tischler Luisa , de Laffolie Jan , van den Berg Neeltje 
Published: December 2022

AbstractThe incidence and prevalence of pediatric-onset inflammatory bowel disease (PIBD) are on the rise worldwide. Initial symptoms are often recognized with a delay, which reduces the quality of life and may lead to an increased rate of complications. The aim of this study was to determine the diagnostic delay in PIBD and to identify potential influencing factors. Therefore, data from the German-Austrian patient registry CEDATA-GPGE for children and adolescents with PIBD were analyzed for the period January 2014 to December 2018. There were 456 children identified in the data, thereof 258 children (57%) with Crohn’s disease (CD) and 198 children (43%) with Ulcerative colitis (UC). The median age was 13.3 years (interquartile range (IQR) = 10.9−15.0), and 44% were females. The median diagnostic delay was 4.1 months (IQR = 2.1–7.0) in CD and 2.4 months (IQR = 1.2–5.1) in UC (p = 0.01). UC was associated with earlier diagnosis than CD (p < 0.001). Only a few factors influencing the diagnostic delay have been verified, e.g., abdominal pain at night and if video capsule endoscopy was performed. Diagnostic delay improved over the years in participating centers, but the level of awareness needs to be high even in common symptoms like abdominal pain.
Drosophila suzukii energetic pathways are differently modulated by nutritional geometry in males and females
Authors: Sario Sara , Mendes Rafael J. , Gonçalves Fátima , Torres Laura , Santos Conceição 
Published: December 2022

AbstractAs a polyphagous pest,Drosophila suzukiihas a variety of host fruits available for feeding and oviposition, but how the nutritional geometry of different hosts influences its metabolism is still poorly understood. This work aimed to evaluate howD. suzukiimetabolic and transcriptional pathways are influenced by feeding on different host fruits, and how sex influences these responses. Adult flies were allowed to feed on five different fruit-based media. Lipids, glucose, glycogen, and energy pathways-associated gene expression, were quantified. Females showed an energetic metabolism easily adaptable to the food’s nutritional characteristics; in contrast, males’ energetic metabolism was particularly influenced by food, predominantly those fed on raspberry media who showed changes in glucose levels and in the expression of genes associated with metabolic pathways, suggesting activation of gluconeogenesis and trehaloneogenesis as a result of nutritional deficiency. Here we present novel insight into howD. suzukii’s energetic pathways are modulated depending on fruits’ nutritional geometry and sex. While the females showed high adaptability in their energetic metabolism to the diet, males were more feeding-sensitive. These findings might be used not only to control this pest population but to better advise producers to invest in less suitable fruits based on the hosts’ nutritional geometry.
Assessment of a consensus definition of obesity and metabolic health phenotypes in children at different pubertal stages
Authors: Pereira Ana , Reyes Marcela , Corvalán Camila , Espejo Juan Pablo , Mericq Verónica , Cifuentes Mariana 
Published: December 2022

AbstractNot all individuals with obesity develop metabolic complications, which has brought about the concepts of metabolically healthy and unhealthy obesity (MHO/MUO). However, inconsistent definitions of these conditions have limited their understanding. We assessed whether a recently-proposed consensus definition for MHO/MUO correlates with adiposity and reflects metabolic risk parameters during puberty. Low-middle income children from the Growth and Obesity Cohort Study (Santiago, Chile) were included (n = 949; 1692 visits at Tanner (T)2, T4 and/or one-year post menarche (1YPM)). Anthropometry, body composition and metabolic parameters were compared between MUO and MHO, and also in children without obesity. The risk for presenting MUO phenotype was significantly elevated with higher waist-height ratio (T2), zBMI (T2, T4), trunk fat, and C-reactive protein (T4). Elevated cardiometabolic indices were important predictors of the “unhealthy” phenotype allocation in children with or without obesity. Our observations suggest that the consensus definition in children at T2, T4 and 1YPM reflects metabolic risk and central obesity. Metabolic health phenotype allocation by this equation enables easy detection of risk factors that call for action to prevent long-term metabolic derangements in children with obesity and, importantly, also those without obesity.
Temporal and regulatory dynamics of the inner ear transcriptome during development in mice
Authors: Cao Rui , Takechi Masaki , Wang Xiuwan , Furutera Toshiko , Nojiri Taro , Koyabu Daisuke , Li Jun 
Published: December 2022

AbstractThe inner ear controls hearing and balance, while the temporal molecular signatures and transcriptional regulatory dynamics underlying its development are still unclear. In this study, we investigated time-series transcriptome in the mouse inner ear from embryonic day 11.5 (E11.5) to postnatal day 7 (P7) using bulk RNA-Seq. A total of 10,822 differentially expressed genes were identified between pairwise stages. We identified nine significant temporal expression profiles using time-series expression analysis. The constantly down-regulated profiles throughout the development are related to DNA activity and neurosensory development, while the constantly upregulated profiles are related to collagen and extracellular matrix. Further co-expression network analysis revealed that several hub genes, such as Pnoc, Cd9, and Krt27, are related to the neurosensory development, cell adhesion, and keratinization. We uncovered three important transcription regulatory paths during mice inner ear development. Transcription factors related to Hippo/TGFβ signaling induced decreased expressions of genes related to the neurosensory and inner ear development, while a series of INF genes activated the expressions of genes in immunoregulation. In addition to deepening our understanding of the temporal and regulatory mechanisms of inner ear development, our transcriptomic data could fuel future multi-species comparative studies and elucidate the evolutionary trajectory of auditory development.