bluuebunny/crossref_metadata_2025_split huggingface dataset:
An integrative model for the comprehensive classification of BRCA1 and BRCA2 variants of uncertain clinical significance
Authors: Iversen Edwin S. , Lipton Gary , Hart Steven N. , Lee Kun Y. , Hu Chunling , Polley Eric C. , Pesaran Tina , Yussuf Amal , LaDuca Holly , Chao Elizabeth , Karam Rachid , Goldgar David E. , Couch Fergus J. , Monteiro Alvaro N. A. 
Published: June 2022

AbstractLoss-of-function variants in the BRCA1 and BRCA2 susceptibility genes predispose carriers to breast and/or ovarian cancer. The use of germline testing panels containing these genes has grown dramatically, but the interpretation of the results has been complicated by the identification of many sequence variants of undefined cancer relevance, termed “Variants of Uncertain Significance (VUS).” We have developed functional assays and a statistical model called VarCall for classifying BRCA1 and BRCA2 VUS. Here we describe a multifactorial extension of VarCall, called VarCall XT, that allows for co–analysis of multiple forms of genetic evidence. We evaluated the accuracy of models defined by the combinations of functional, in silico protein predictors, and family data for VUS classification. VarCall XT classified variants of known pathogenicity status with high sensitivity and specificity, with the functional assays contributing the greatest predictive power. This approach could be used to identify more patients that would benefit from personalized cancer risk assessment and management.
A review of sampling, energy supply and intelligent monitoring for long-term sweat sensors
Authors: Yang Pufan , Wei Gaofeng , Liu Ang , Huo Fengwei , Zhang Zhinan 
Published: June 2022

AbstractSweat is a biofluid with rich information that can reflect an individual’s state of health or activity. But the real-time in situ sweat sensors lack the ability of long-term monitoring. Against this background, this article provides a holistic review on the necessary process and methods for sweat sensing, including sweat collection, composition analysis, energy supply, and data processing. The impacts of the environment in stimulating sweat production, providing energy supply, and intelligent health monitoring are discussed. Based on the review of previous endeavors, the future development in material, structure and artificial intelligence application of long-term sweat monitoring is envisioned.
On the accurate characterization of quantum-dot light-emitting diodes for display applications
Authors: Jin Wangxiao , Deng Yunzhou , Guo Bingbing , Lian Yaxiao , Zhao Baodan , Di Dawei , Sun Xiaowei , Wang Kai , Chen Shuming , Yang Yixing , Cao Weiran , Chen Song , Ji Wenyu , Yang Xuyong , Gao Yuan , Wang Shuangpeng , Shen Huaibin , Zhao Jialong , Qian Lei , Li Fushan , Jin Yizheng 
Published: June 2022

AbstractQuantum dot light-emitting diodes (QLEDs) are a class of high-performance solution-processed electroluminescent (EL) devices highly attractive for next-generation display applications. Despite the encouraging advances in the mechanism investigation, material chemistry, and device engineering of QLEDs, the lack of standard protocols for the characterization of QLEDs may cause inaccurate measurements of device parameters and invalid comparison of different devices. Here, we report a comprehensive study on the characterizations of QLEDs using various methods. We show that the emission non-uniformity across the active area, non-Lambertian angular distributions of EL intensity, and discrepancies in the adopted spectral luminous efficiency functions could introduce significant errors in the device efficiency. Larger errors in the operational-lifetime measurements may arise from the inaccurate determination of the initial luminance and inconsistent methods for analyzing the luminance-decay curves. Finally, we suggest a set of recommended practices and a checklist for device characterizations, aiming to help the researchers in the QLED field to achieve accurate and reliable measurements.
Leaf-meridian bio-inspired nanofibrous electronics with uniform distributed microgrid and 3D multi-level structure for wearable applications
Authors: Wang Mingxu , Dong Li , Wu Jiajia , Shi Jian , Gao Qiang , Zhu Chunhong , Morikawa Hideaki 
Published: June 2022

AbstractThe interface between the active electronic and its osculatory target dominates the sensing response of high-sensitivity sensors. However, the interface properties are difficult to be adjusted and preserved owing to the limited strategies for surface engineering. In this work, inspired by nature frond leaf, a spatial multi-level nanofibrous membrane with grid-like microstructure of uniform distribution was fabricated, in which carboxylated carbon nanotubes (CCNTs)/poly(3,4-ethylenedioxythiophene) (PEDOT) was modified onto the surface of grid-like polyurethane (PU) nanofiber via the combination of metal mesh template, in situ polymerization and ultrasonic treatment. Nanofibrous membrane enables a pressure sensor with high sensitivities (5.13 kPa−1), fast response/recovery time (80 ms and 120 ms), and ultralow detection limit of 1 Pa. In addition, as a scalable and integrable platform, we also demonstrate its multifunctional applications for electro-thermal conversion and energy harvesting. All these results indicate the proposed nanofibrous membrane may potentially be applied to next-generation wearable devices.
Enhancement of superconductivity on the verge of a structural instability in isovalently doped β-ThRh1−xIrxGe
Authors: Xiao Guorui , Zhu Qinqing , Cui Yanwei , Yang Wuzhang , Li Baizhuo , Song Shijie , Cao Guang-Han , Ren Zhi 
Published: June 2022

Abstractβ-ThRhGe, the high-temperature polymorph of ThRhGe, is isostructural to the well-known ferromagnetic superconductor URhGe. However, contrary to URhGe,β-ThRhGe is nonmagnetic and undergoes an incomplete structural phase transition at 244 K, followed by a superconducting transition below 3.36 K. Here we show that the isovalent substitution of Ir for Rh leads to a strong enhancement of superconductivity by suppressing the structural transition. Atx = 0.5, where the structural transition disappears,Tcreaches a maximum of 6.88 K. The enhancement of superconductivity is linked to the proximity to a structural quantum critical point at this Ir concentration, as suggested by the analysis of thermodynamic as well as resistivity data. First principles calculations indicate that the Ir doping has little effect on the electronic band dispersion near the Fermi level.β-ThRh1−xIrxGe thus provides an excellent platform to study the interplay between superconductivity and structural quantum criticality in actinide-containing compounds.
Electronic nature of the pseudogap in electron-doped Sr2IrO4
Authors: Peng Shuting , Lane Christopher , Hu Yong , Guo Mingyao , Chen Xiang , Sun Zeliang , Hashimoto Makoto , Lu Donghui , Shen Zhi-Xun , Wu Tao , Chen Xianhui , Markiewicz Robert S. , Wang Yao , Bansil Arun , Wilson Stephen D. , He Junfeng 
Published: June 2022

AbstractIn high-temperature (Tc) cuprate superconductors, many exotic phenomena are rooted in the enigmatic pseudogap state, which has been interpreted as consisting of preformed Cooper pairs or competing orders or a combination thereof. Observation of pseudogap phenomenologically in electron-doped Sr2IrO4—the 5d electron counterpart of the cuprates, has spurred intense interest in the strontium iridates as a testbed for exploring the exotic physics of the cuprates. Here, we examine the pseudogap state of electron-doped Sr2IrO4 by angle-resolved photoemission spectroscopy (ARPES) and parallel theoretical modeling. Our analysis demonstrates that the pseudogap state of Sr2IrO4 appears without breaking the particle–hole symmetry or inducing spectral broadening which are telltale signatures of competing orders in the cuprates. We find quasiparticle dispersion and its temperature dependence in the pseudogap state of Sr2IrO4 to point to an electronic order with a zero scattering wave vector and limited correlation length. Particle–hole symmetric preformed Cooper pairs are discussed as a viable mechanism for such an electronic order. The potential roles of incommensurate density waves are also discussed.
Identification of a highly stable bioactive 3-hydroxyproline-containing tripeptide in human blood after collagen hydrolysate ingestion
Authors: Taga Yuki , Iwasaki Yu , Tometsuka Chisa , Funato Noriko , Shigemura Yasutaka , Kusubata Masashi , Mizuno Kazunori 
Published: June 2022

AbstractThere are increasing reports demonstrating high bioavailability of 4-hydroxyproline (4Hyp)-containing oligopeptides after oral ingestion of collagen hydrolysate and their bioactivity. In contrast, no study investigates the fate of another collagen-specific but minor amino acid, 3Hyp. Here, we identified Gly-3Hyp-4Hyp tripeptide in human blood at high concentrations, comparable to other 4Hyp-containing oligopeptides, after ingesting porcine skin collagen hydrolysate. Additionally, Gly-3Hyp-4Hyp uniquely maintained the maximum concentration until 4 h after the ingestion due to its exceptionally high resistance to peptidase/protease demonstrated by incubation with mouse plasma. In mice, oral administration of collagen hydrolysate prepared from bovine tendon, which contains a higher amount of 3Hyp, further increased blood Gly-3Hyp-4Hyp levels compared to that from bovine skin. Furthermore, Gly-3Hyp-4Hyp showed chemotactic activity on skin fibroblasts and promoted osteoblast differentiation. These results highlight the specific nature of the Gly-3Hyp-4Hyp tripeptide and its potential for health promotion and disease treatment.
Voluntary consensus based geospatial data standards for the global illegal trade in wild fauna and flora
Authors: Gore Meredith L. , Schwartz Lee R. , Amponsah-Mensah Kofi , Barbee Emily , Canney Susan , Carbo-Penche Maria , Cronin Drew , Hilend Rowan , Laituri Melinda , Luna David , Maina Faith , Mey Christian , Mumford Kathleena , Mugo Robinson , Nduguta Redempta , Nyce Christopher , McEvoy John , McShea William , Mandimbihasina Angelo , Salafsky Nick , Smetana David , Tait Alexander , Wittig Tim , Wright Dawn , Naess Leah Wanambwa 
Published: June 2022

AbstractWe have more data about wildlife trafficking than ever before, but it remains underutilized for decision-making. Central to effective wildlife trafficking interventions is collection, aggregation, and analysis of data across a range of source, transit, and destination geographies. Many data are geospatial, but these data cannot be effectively accessed or aggregated without appropriate geospatial data standards. Our goal was to create geospatial data standards to help advance efforts to combat wildlife trafficking. We achieved our goal using voluntary, participatory, and engagement-based workshops with diverse and multisectoral stakeholders, online portals, and electronic communication with more than 100 participants on three continents. The standards support data-to-decision efforts in the field, for example indictments of key figures within wildlife trafficking, and disruption of their networks. Geospatial data standards help enable broader utilization of wildlife trafficking data across disciplines and sectors, accelerate aggregation and analysis of data across space and time, advance evidence-based decision making, and reduce wildlife trafficking.
Inter-species cell detection - datasets on pulmonary hemosiderophages in equine, human and feline specimens
Authors: Marzahl Christian , Hill Jenny , Stayt Jason , Bienzle Dorothee , Welker Lutz , Wilm Frauke , Voigt Jörn , Aubreville Marc , Maier Andreas , Klopfleisch Robert , Breininger Katharina , Bertram Christof A. 
Published: June 2022

AbstractPulmonary hemorrhage (P-Hem) occurs among multiple species and can have various causes. Cytology of bronchoalveolar lavage fluid (BALF) using a 5-tier scoring system of alveolar macrophages based on their hemosiderin content is considered the most sensitive diagnostic method. We introduce a novel, fully annotated multi-species P-Hem dataset, which consists of 74 cytology whole slide images (WSIs) with equine, feline and human samples. To create this high-quality and high-quantity dataset, we developed an annotation pipeline combining human expertise with deep learning and data visualisation techniques. We applied a deep learning-based object detection approach trained on 17 expertly annotated equine WSIs, to the remaining 39 equine, 12 human and 7 feline WSIs. The resulting annotations were semi-automatically screened for errors on multiple types of specialised annotation maps and finally reviewed by a trained pathologist. Our dataset contains a total of 297,383 hemosiderophages classified into five grades. It is one of the largest publicly available WSIs datasets with respect to the number of annotations, the scanned area and the number of species covered.
Strontium isotopes and concentrations in cremated bones suggest an increased salt consumption in Gallo-Roman diet
Authors: Dalle Sarah , Snoeck Christophe , Sengeløv Amanda , Salesse Kevin , Hlad Marta , Annaert Rica , Boonants Tom , Boudin Mathieu , Capuzzo Giacomo , Gerritzen Carina T. , Goderis Steven , Sabaux Charlotte , Stamataki Elisavet , Vercauteren Martine , Veselka Barbara , Warmenbol Eugène , De Mulder Guy 
Published: June 2022

AbstractThe high temperatures reached during cremation lead to the destruction of organic matter preventing the use of traditional isotopic methods for dietary reconstructions. Still, strontium isotope (87Sr/86Sr) and concentration ([Sr]) analyses of cremated human remains offer a novel way to assess changing consumption patterns in past populations that practiced cremation, as evidenced by a large amount of new data obtained from Metal Ages and Gallo-Roman human remains from Destelbergen, Belgium. The Gallo-Roman results show significantly higher [Sr] and a narrower interquartile range in 87Sr/86Sr (0.7093–0.7095), close to the value of modern-day seawater (0.7092). This contrasts with the Metal Ages results, which display lower concentrations and a wider range in 87Sr/86Sr (0.7094–0.7098). This typical Sr signature is also reflected in other sites and is most likely related to an introduction of marine Sr in the form of salt as a food preservative (e.g. salt-rich preserved meat, fish and fish sauce). Paradoxically, this study highlights caution is needed when using 87Sr/86Sr for palaeomobility studies in populations with high salt consumption.
Multiple entrained oscillator model of food anticipatory circadian rhythms
Authors: Petersen Christian C. , Cao Federico , Stinchcombe Adam R. , Mistlberger Ralph E. 
Published: June 2022

AbstractFor many animal species, knowing when to look for food may be as important as knowing where to look. Rats and other species use a feeding-responsive circadian timing mechanism to anticipate, behaviorally and physiologically, a predictable daily feeding opportunity. How this mechanism for anticipating a daily meal accommodates more than one predictable mealtime is unclear. Rats were trained to press a lever for food, and then limited to one or more daily meals at fixed or systematically varying times of day. The rats were able to anticipate up to 4 of 4 daily meals at fixed times of day and two ‘daily’ meals recurring at 24 h and 26 h intervals. When deprived of food, in constant dark, lever pressing recurred for multiple cycles at expected mealtimes, consistent with the periodicity of the prior feeding schedule. Anticipation did not require the suprachiasmatic nucleus circadian pacemaker. The anticipation rhythms could be simulated using a Kuramoto model in which clusters of coupled oscillators entrain to specific mealtimes based on initial phase and intrinsic circadian periodicity. A flexibly coupled system of food-entrainable circadian oscillators endows rats with adaptive plasticity in daily programming of foraging activity.
Chimpanzee (Pan troglodytes) gaze is conspicuous at ecologically-relevant distances
Authors: Whitham Will , Schapiro Steven J. , Troscianko Jolyon , Yorzinski Jessica L. 
Published: June 2022

AbstractChimpanzee (Pan troglodytes) sclera appear much darker than the white sclera of human eyes, to such a degree that the direction of chimpanzee gaze may be concealed from conspecifics. Recent debate surrounding this topic has produced mixed results, with some evidence suggesting that (1) primate gaze is indeed concealed from their conspecifics, and (2) gaze colouration is among the suite of traits that distinguish uniquely social and cooperative humans from other primates (the cooperative eye hypothesis). Using a visual modelling approach that properly accounts for specific-specific vision, we reexamined this topic to estimate the extent to which chimpanzee eye coloration is discriminable. We photographed the faces of captive chimpanzees and quantified the discriminability of their pupil, iris, sclera, and surrounding skin. We considered biases of cameras, lighting conditions, and commercial photography software along with primate visual acuity, colour sensitivity, and discrimination ability. Our visual modeling of chimpanzee eye coloration suggests that chimpanzee gaze is visible to conspecifics at a range of distances (within approximately 10 m) appropriate for many species-typical behaviours. We also found that chimpanzee gaze is discriminable to the visual system of primates that chimpanzees prey upon, Colobus monkeys. Chimpanzee sclera colour does not effectively conceal gaze, and we discuss this result with regard to the cooperative eye hypothesis, the evolution of primate eye colouration, and methodological best practices for future primate visual ecology research.
Sustainable multifunctional phenolic lipids as potential therapeutics in Dentistry
Authors: Dame-Teixeira Naile , El-Gendy Reem , Monici Silva Isabela , Holanda Cleonice Andrade , de Oliveira Andressa Souza , Romeiro Luiz Antonio Soares , Do Thuy 
Published: June 2022

AbstractPhenolic lipids components of the cashew nutshell liquid (CNSL) have molecular structures capable of chemical signalling that regulate gene expression, metabolism and inflammation. This study sets out to assess how CNSL derivatives impact oral bacteria, from an antibacterial and anti-collagenolytic perspective, as well as its biocompatibility with dental pulp stem cells. Two hemi-synthetic saturated CNSL derivative compounds were selected (LDT11-Anacardic Acids-derivative and LDT409-cardanol-derivative). Bacteriostatic activity was tested against Streptococcus mutans and Veillonella parvula. Antimicrobial capacity against preformed S. mutans biofilms was investigated using a collagen-coated Calgary Biofilm Device and confocal microscopy. Clostridium histolyticum, P. gingivalis and S. mutans biofilms were used to assess anti-collagenolytic activity. Biocompatibility with human dental pulp stromal cells (HDPSCs) was investigated (MTT for viability proportion, LDH assays for cell death rate). LDTs inhibited the bacterial growth, as well as partially inhibited bacterial collagenases in concentrations higher than 5 μg/mL. Dose–response rates of biofilm cell death was observed (LDT11 at 20, 50, 100 μg/mL = 1.0 ± 0.4, 0.7 ± 0.3, 0.6 ± 0.03, respectively). Maximum cytotoxicity was 30%. After 1 week, LDT409 had no HDPSCs death. HDPSCs viability was decreased after 24 h of treatment with LDT11 and LDT409, but recovered at 72 h and showed a massive increase in viability and proliferation after 1 week. LDTs treatment was associated with odontoblast-like morphology. In conclusion, LDT11 multifunctionality and biocompatibility, stimulating dental pulp stem cells proliferation and differentiation, indicates a potential as a bio-based dental material for regenerative Dentistry. Its potential as a bacterial collagenases inhibitor to reduce collagen degradation in root/dentinal caries can be further explored.
Sex stratification of the trends and risk of mortality among individuals living with HIV under different transmission categories
Authors: Lee Chun-Yuan , Lin Yi-Pei , Tu Hung-Pin , Wang Sheng-Fan , Lu Po-Liang 
Published: June 2022

AbstractWe retrospectively examined 33,142 persons living with HIV (PLWH) in Taiwan from a nationwide database to assess sex-stratified trends and risk of all-cause mortality under different transmission categories from 1984 to 2016. Overall, 61.25% were men who have sex with men (MSM), 14.37% were men who have sex with women (MSW), 18.32% were male persons who inject drugs (M-PWID), 3.30% were women who have sex with men (WSM), and 2.74% were female PWID (F-PWID). All-cause mortality (per 100 person-years) among heterosexual people and PWID was higher in men (4.04 and 3.39, respectively) than in women (2.93 and 2.18, respectively). In each sex-stratified transmission category, the all-cause mortality reduced substantially from 1984–1996 to 2012–2016, but evolved distinctly from 2007–2011 to 2012–2016. Since 2007–2011, the decline in all-cause mortality has slowed notably in the groups with sexually transmitted HIV, but has increased in PWID, surpassing even that among groups with sexually transmitted HIV in 2012–2016. PLWH with sexually transmitted HIV had lower risks of all-cause mortality than PWID, regardless of sex. Sex and transmission category did not interact significantly on all-cause mortality. Understanding the reasons for the distinct evolving trends of all-cause mortality in each transmission category serves as a reference for developing strategies to reduce mortality in PLWH in Taiwan further.
Preliminary study on parameterization of raw electrical bioimpedance data with 3 frequencies
Authors: González-Correa C. A. , Jaimes S. A. , Cárdenas-Jiménez J. I. 
Published: June 2022

AbstractThis study tests the geometrical parameterization method for Electrical Bio-Impedance Spectroscopy (EBIS) readings previously proposed by one of the authors. This method uses the data of just three frequencies (therefore called 3P method). The test was carried out by the analysis of parameterization from 26 spectra (selected from 13 data sets) by the non-linear square (NLS) method, the 3P method and a combination of the two (3P-NLS). Additionally, the behaviour of the 3P method for 4 levels of noise and 3 different ways of segmenting the spectra were also explored with a MATLAB simulation of 400 spectra. Finally, a system for the classification of EBIS readings is presented, based on deviations of the raw data from the semi-circle obtained by the parameterization methods. Overall, the results suggest a very good performance of the 3P method when compared with the other two. The 3P method performs very well with levels of noise of 1 and 2%, but performs poorly with levels of noise of 5% and 10%. The results support the idea that the 3P method could be used with confidence for the parameterization of EBIS spectra, after the selection of three adequate frequencies according to specific applications.