bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interface-Coupling of NiFe-LDH on Exfoliated Black Phosphorus for the High-Performance Electrocatalytic Oxygen Evolution Reaction
Authors: Fan Jinchen , Qin Xi , Jiang Wendan , Lu Xiaolei , Song Xueling , Guo Wenyao , Zhu Sheng 
Published: July 2022

Electrochemical oxygen evolution reaction (OER) always plays an important role in many electrochemical energy storage and conversion systems. Owing to the slow kinetics mainly brought from multiple proton-coupled electron transfer steps, the design and exploit low-cost, highly active, durable OER electrocatalysts are of significant importance. Although the black phosphorus (BP) shows good electrocatalytic OER performance, it still faces the problems of poor intrinsic activity and low stability due to its instability under ambient conditions. The NiFe-LDH was assembled onto the surfaces of exfoliated BP (EBP) nanoflakes to realize the interfacial coupling between them, achieving an effective improvement in electrocatalytic activity and stability. Benefitting from the interfacial P-O bonding, the NiFe-LDH@EBP hybrid shows high OER activity with a low overpotential of ∼240 mV@10 mA cm−2 toward OER under alkaline conditions, as well as the good stability. Density functional theory (DFT) calculations proved that the interface-coupling of NiFe-LDH on BP promotes charge transfer kinetics and balances the adsorption/desorption of reaction intermediates, ultimately imparting excellent OER electrocatalytic activity.
Strain Effects on the Electronic and Optical Properties of Blue Phosphorene
Authors: Zhang Lin , Cui Zhen 
Published: July 2022

Monolayer blue phosphorene (BlueP) systems were investigated under biaxial strain range from −10% to +10%. All these systems exhibit excellent stability, accompanying changes in the electronic and optical properties. BlueP becomes metallic at −10% strain and transforms into a direct semiconductor at 10% strain while maintaining indirect semiconductor behaviors at −8% to +8% strain. The bandgap of BlueP decreases linearly with strain, and tensile strain exhibits a more moderate bandgap modulation than compressive strain. The real part of the dielectric function of BlueP is enhanced under compressive strain, while the optical absorption in the visible and the infrared light regions increases significantly under tensile strain. The maximum absorption coefficient of 0.52 ×105/cm occurs at 530 nm with the 10% strain. Our analysis indicates that the semiconductor–metal transition and the indirect–direct bandgap transition are the competition results of the energy states near the Fermi level under a massive strain. The potent compressive strain leads the py orbitals of the conduction band to move downward and pass through the Fermi level at the K point. The robust tensile strain guides the energy states at the Γ point to approach the Fermi level and become the band edges. Our results suggest that the energy storage capacity of BlueP can be significantly improved by compressive strain, while the visible light photocatalytic performance is enhanced by tensile strains of less than 8%. Our works provide a reference for the practical applications of BlueP in photocatalyst, photovoltaic cells, and electronic devices.
Comparison of the Efficacy of ECMO With or Without IABP in Patients With Cardiogenic Shock: A Meta-Analysis
Authors: Zeng Ping , Yang Chaojun , Chen Jing , Fan Zhixing , Cai Wanyin , Huang Yifan , Xiang Zujin , Yang Jun , Zhang Jing , Yang Jian 
Published: July 2022

ObjectiveStudies on extracorporeal membrane oxygenation (ECMO) with and without an intra-aortic balloon pump (IABP) for cardiogenic shock (CS) have been published, but there have been no meta-analyses that compare the efficacy of these two cardiac support methods. This meta-analysis evaluated the outcomes of these two different treatment measures.MethodsThe PubMed, Embase, Cochrane Library, Web of Science, and Clinical Trials databases were searched until March 2022. Studies that were related to ECMO with or without IABP in patients with CS were screened. Quality assessments were evaluated with the methodological index for nonrandomized studies (MINORS). The primary outcome was in-hospital survival, while the secondary outcomes included duration of ECMO, duration of ICU stay, infection/sepsis, and bleeding. Revman 5.3 and STATA software were used for this meta-analysis.ResultsIn total, nine manuscripts with 2,573 patients were included in the systematic review. CS patients who received ECMO in combination with IABP had significantly improved in-hospital survival compared with ECMO alone (OR = 1.58, 95% CI = 1.26–1.98, P &lt; 0.0001). However, there were no significant differences in the duration of ECMO (MD = 0.36, 95% CI = −0.12–0.84, P = 0.14), duration of ICU stay (MD = −1.95, 95% CI = −4.05–0.15, P = 0.07), incidence of infection/sepsis (OR = 1.0, 95% CI = 0.58–1.72, P = 1.0), or bleeding (OR = 1.28, 95% CI = 0.48–3.45, P = 0.62) between the two groups of patients with CS.ConclusionECMO combined with IABP can improve in-hospital survival more effectively than ECMO alone in patients with CS.
Study on Critical Damage Width of Parallel Double-Free Surface Blasting
Authors: Shi Jianjun , Miao Xiaopeng , Meng Haili , An Huaming , Zhang Wei 
Published: July 2022

Reserved rock wall is usually used in blasting operation when one side has an important protection object. Rock wall demolition blasting was essentially a parallel double-free surface blasting; blasting is the ideal effect of casting a side fully broken rock mass, throwing, on the other side (protection) of rock mass at the injury status of “broken and do not come loose”; the minimum thickness of the rock wall last could hole to protect the width of side of the free surface, called the critical damage width. First, based on the theory of multi-boundary blasting, the relationship among the throwing effect, boundary condition, and charge quantity of parallel double-free surface blasting is expounded in this article. The model of equivalent sub-charge package was established to deduce the relationship of bilateral resistance lines, and the theoretical value of critical damage width was 2.05 W (minimum resistance line). Second, according to the rock wall demolition and blasting of the Yangtou station renovation project in the second line of Yuhuai, the critical damage width of 2.5 W was measured through a single row and hole-by-hole detonation field test. The results of study on critical damage width of parallel double-free surface blasting can provide theoretical guidance for similar projects.
Adverse Event Reporting Quality in Cancer Clinical Trials Evaluating Immune Checkpoint Inhibitor Therapy: A Systematic Review
Authors: Wang Yuhong , Chen Chen , Du Wei , Zhou Yixin , He Lina , Hong Shaodong , Zhang Li 
Published: July 2022

BackgroundImmunotherapy has become one of the most important breakthroughs in cancer treatment. Consequently, there have been more immuno-oncology (IO) clinical trials for various cancers in recent decades. However, the quality of such trials in reporting adverse events (AE), especially immune-related AE (irAE), has not been comprehensively evaluated.MethodsWe evaluated the harm reporting quality of IO trials. The PubMed, Embase, Cochrane Library, and Web of Science databases were searched to identify all head-to-head phase II and III clinical trials assessing cancer immunotherapy published between January 1, 2010, and December 31, 2021. Publications were assessed using a 16-point harm reporting quality score (HRQS) derived from the 2004 Consolidated Standards of Reporting Trials (CONSORT) extension. The characteristics associated with improved reporting quality were identified with linear regression.ResultsA total of 123 publications were included. The mean HRQS was 11.1 (range, 5-14). The most common poorly reported items were harms addressed in the title (2%), AE collection methodology (3%), the statistical approach for analyzing harms (11%), and the irAE onset patterns and management (adequately reported in 14% and 33% of publications, respectively). The harm information was well described in the publications’ Results and Discussion sections (89-99%). The multivariable regression model revealed that higher impact factor (IF) (30&lt;IF&lt;60 vs. IF&lt;30, P=0.021) and phase III clinical trial (phase III vs. phase II, P=0.023) were independent predictors of higher quality score.ConclusionOur findings show that AE reporting in IO randomized trials is suboptimal. Efforts should be made to improve harm reporting and to standardize reporting practices. Improvements in AE reporting would permit more balanced assessment of interventions and would enhance evidence-based IO practice.
Transcriptome Analysis of Tumor-Infiltrating Lymphocytes Identifies NK Cell Gene Signatures Associated With Lymphocyte Infiltration and Survival in Soft Tissue Sarcomas
Authors: Judge Sean J. , Bloomstein Joshua D. , Sholevar Cyrus J. , Darrow Morgan A. , Stoffel Kevin M. , Vick Logan V. , Dunai Cordelia , Cruz Sylvia M. , Razmara Aryana M. , Monjazeb Arta M. , Rebhun Robert B. , Murphy William J. , Canter Robert J. 
Published: July 2022

PurposeClinical successes using current T-cell based immunotherapies have been limited in soft tissue sarcomas (STS), while pre-clinical studies have shown evidence of natural killer (NK) cell activity. Since tumor immune infiltration, especially tumor-infiltrating lymphocytes, is associated with improved survival in most solid tumors, we sought to evaluate the gene expression profile of tumor and blood NK and T cells, as well as tumor cells, with the goal of identifying potential novel immune targets in STS.Experimental DesignUsing fluorescence-activated cell sorting, we isolated blood and tumor-infiltrating CD3-CD56+ NK and CD3+ T cells and CD45- viable tumor cells from STS patients undergoing surgery. We then evaluated differential gene expression (DGE) of these purified populations with RNA sequencing analysis. To evaluate survival differences and validate primary DGE results, we also queried The Cancer Genome Atlas (TCGA) database to compare outcomes stratified by bulk gene expression.ResultsSorted intra-tumoral CD3+ T cells showed significant upregulation of established activating (CD137) and inhibitory genes (TIM-3) compared to circulating T cells. In contrast, intra-tumoral NK cells did not exhibit upregulation of canonical cytotoxic genes (IFNG, GZMB), but rather significant DGE in mitogen signaling (DUSP4) and metabolic function (SMPD3, SLC7A5). Tumors with higher NK and T cell infiltration exhibited significantly increased expression of the pro-inflammatory receptor TLR4 in sorted CD45- tumor cells. TCGA analysis revealed that tumors with high TLR4 expression (P = 0.03) and low expression of STMN1 involved in microtubule polymerization (P &lt; 0.001) were associated with significantly improved survival.ConclusionsUnlike T cells, which demonstrate significant DGE consistent with upregulation of both activating and inhibiting receptors in tumor-infiltrating subsets, NK cells appear to have more stable gene expression between blood and tumor subsets, with alterations restricted primarily to metabolic pathways. Increased immune cell infiltration and improved survival were positively correlated with TLR4 expression and inversely correlated with STMN1 expression within tumors, suggesting possible novel therapeutic targets for immunotherapy in STS.
The Potential Predictive Biomarkers for Advanced Hepatocellular Carcinoma Treated With Anti-Angiogenic Drugs in Combination With PD-1 Antibody
Authors: Liu Chenxi , Zhu Sihui , Dong Yanbing , Shao Jie , Liu Baorui , Shen Jie 
Published: July 2022

BackgroundBased on molecular biomarkers, anti-angiogenic drugs in combination with programmed cell death protein 1 (PD-1) antibodies can screen the potentially beneficial populations with hepatocellular carcinoma (HCC) and predict the efficacy after treatment. Therefore, we aimed to study predictive molecular biomarkers to improve the effectiveness of immuno-targeted combination therapy for HCC.Patients and MethodsBaseline clinical data, blood samples, and imaging data of the first evaluation after two cycles of treatment were collected for 40 patients with advanced HCC who underwent combination therapy, and then these data were compared according to the efficacy. Since 15 patients had complete hematology samples, we additionally tested the T lymphocyte subpopulations of these 15 patients and also compared them according to the efficacy. In addition, we also selected five patients who benefited the most from the combination therapy and five patients with the worst curative effect for gene detection based on survival time and efficacy evaluation. Finally, the relationship between certain clinical characteristics, laboratory indicators, specific T lymphocyte subpopulations, gene mutations and the response of immuno-targeted combination therapy for HCC was evaluated.ResultsThe high levels of CD3+CD4+CD279+, CD3+CD8+CD45RO+CD62L+T lymphocytes and tumor mutational burden (TMB) were associated with good efficacy of the combination therapy (P=0.03, P&lt;0.01 and P=0.03). The high levels of CD3+CD4+CD28+ T lymphocytes were associated with poor efficacy of the combination therapy (P=0.02). The high mutation frequency of TP53 and ARID1A appeared in the non-response cohort. In addition, amplification mutation of 11q13-CCND1, FGF3, FGF4, and FGF19 was found in a patient with hyperprogression (HP).ConclusionsThe certain clinical characteristics, laboratory indicators, specific T lymphocyte subpopulations, and gene mutations established in this paper were potential predictive biomarkers for HCC patients treated with combination therapy.
Electric-Field Control of Magnetoresistance Behavior in a Conetic Alloy Thin Film/Pb(Mg1/3Nb2/3)0.7Ti0.3O3 Multiferroic Heterostructure
Authors: Wang Cangmin , Huang Wenyu , Wang Chi , Li Lu , Wei Chong , Sun Yuchen , Ge Weifeng , Mao Xiaoli , Li Qiang , Yang Yuanjun , Jia Cheng , Zhang Hui , Luo Zhenlin , Gao Chen 
Published: July 2022

In this work, we investigate the influence of electric fields (E-fields) on the room-temperature magnetotransport behavior of an artificial multiferroic heterostructure, a Conetic alloy (Ni77Fe14Cu5Mo4) thin film/Pb(Mg1/3Nb2/3)0.7Ti0.3O3 (011). When the external magnetic field is parallel to the applied current, the switching field increases from 0.8 to 3.3 Oe at 0 and 8 kV/cm, respectively, and the corresponding magnetoresistance (MR) ratio at 20 Oe respectively decreases from 0.14% to 0.03% at 0 and 8 kV/cm. However, when the external magnetic field is perpendicular to the current, the switching field decreases from 10.1 to 1.7 Oe at 0 and 8 kV/cm, and the MR ratio in such a case decreases from −0.001% to −0.10%, respectively. Consequently, under the parallel and perpendicular modes, the tunabilities of the switching field are approximately +313% and −83%, and the MR ratio tunabilities under E-fields are approximately −79% and +9,900%, respectively. Such a large and anisotropic tunability of both the switching field and MR ratio is attributed to the ultrasoft magnetic property of the Conetic alloy thin film and anisotropic in-plane strain-mediated magnetoelectric coupling. However, the anisotropic MR ratio is approximately 0.15% and does not vary with the applied E-fields owing to the intrinsic property of Conetic thin films using transfer and circle transfer curve measurements, rather than the magnetization rotation caused by E-field-induced magnetoelastic anisotropy. This work demonstrates that multiferroic heterostructures with electrically tunable MR show considerable potential in designing energy-efficient electronic and spintronic devices.
Pathological Findings Associated With SARS-CoV-2 on Postmortem Core Biopsies: Correlation With Clinical Presentation and Disease Course
Authors: Ramos-Rincon Jose-Manuel , Herrera-García Cristian , Silva-Ortega Sandra , Portilla-Tamarit Julia , Alenda Cristina , Jaime-Sanchez Francisco-Angel , Arenas-Jiménez Juan , Fornés-Riera Francisca-Eugenia , Scholz Alexander , Escribano Isabel , Pedrero-Castillo Víctor , Muñoz-Miguelsanz Carlos , Orts-Llinares Pedro , Martí-Pastor Ana , Amo-Lozano Antonio , García-Sevila Raquel , Ribes-Mengual Isabel , Moreno-Perez Oscar , Concepcion-Aramendía Luis , Merino Esperanza , Sánchez-Martínez Rosario , Aranda Ignacio 
Published: July 2022

BackgroundAutopsies can shed light on the pathogenesis of new and emerging diseases.AimTo describe needle core necropsy findings of the lung, heart, and liver in decedents with COVID-19.MaterialCross-sectional study of needle core necropsies in patients who died with virologically confirmed COVID-19. Histopathological analyses were performed, and clinical data and patient course evaluated.ResultsChest core necropsies were performed in 71 decedents with a median age of 81 years (range 52–97); 47 (65.3%) were men. The median interval from symptoms onset to death was 17.5 days (range 1–84). Samples of lung (n = 62, 87.3%), heart (n = 48, 67.6%) and liver (n = 39, 54.9%) were obtained. Fifty-one lung samples (82.3%) were abnormal: 19 (30.6%) showed proliferative diffuse alveolar damage (DAD), 12 (19.4%) presented exudative DAD, and 10 (16.1%) exhibited proliferative plus exudative DAD. Of the 46 lung samples tested for SARS-CoV-19 by RT-PCR, 39 (84.8%) were positive. DAD was associated with premortem values of lactate dehydrogenase of 400 U/L or higher [adjusted odds ratio (AOR) 21.73; 95% confidence interval (CI) 3.22–146] and treatment with tocilizumab (AOR 6.91; 95% CI 1.14–41.7). Proliferative DAD was associated with an onset-to-death interval of over 15 days (AOR 7.85, 95% CI 1.29–47.80). Twenty-three of the 48 (47.9%) heart samples were abnormal: all showed fiber hypertrophy, while 9 (18.8%) presented fibrosis. Of the liver samples, 29/39 (74.4%) were abnormal, due to steatosis (n = 12, 30.8%), cholestasis (n = 6, 15.4%) and lobular central necrosis (n = 5, 12.8%).ConclusionProliferative DAD was the main finding on lung core needle necropsy in people who died from COVID-19; this finding was related to a longer disease course. Changes in the liver and heart were common.
Cerebrospinal Fluid Cortisol and Dehydroepiandrosterone Sulfate, Alzheimer’s Disease Pathology, and Cognitive Decline
Authors: Ouanes Sami , Clark Christopher , Richiardi Jonas , Maréchal Bénédicte , Lewczuk Piotr , Kornhuber Johannes , Kirschbaum Clemens , Popp Julius 
Published: July 2022

IntroductionElevated cortisol levels have been reported in Alzheimer’s disease (AD) and may accelerate the development of brain pathology and cognitive decline. Dehydroepiandrosterone sulfate (DHEAS) has anti-glucocorticoid effects and it may be involved in the AD pathophysiology.ObjectivesTo investigate associations of cerebrospinal fluid (CSF) cortisol and DHEAS levels with (1) cognitive performance at baseline; (2) CSF biomarkers of amyloid pathology (as assessed by CSF Aβ levels), neuronal injury (as assessed by CSF tau), and tau hyperphosphorylation (as assessed by CSF p-tau); (3) regional brain volumes; and (4) clinical disease progression.Materials and MethodsIndividuals between 49 and 88 years (n = 145) with mild cognitive impairment or dementia or with normal cognition were included. Clinical scores, AD biomarkers, brain MRI volumetry along with CSF cortisol and DHEAS were obtained at baseline. Cognitive and functional performance was re-assessed at 18 and 36 months from baseline. We also assessed the following covariates: apolipoprotein E (APOE) genotype, BMI, and education. We used linear regression and mixed models to address associations of interest.ResultsHigher CSF cortisol was associated with poorer global cognitive performance and higher disease severity at baseline. Cortisol and cortisol/DHEAS ratio were positively associated with tau and p-tau CSF levels, and negatively associated with the amygdala and insula volumes at baseline. Higher CSF cortisol predicted more pronounced cognitive decline and clinical disease progression over 36 months. Higher CSF DHEAS predicted more pronounced disease progression over 36 months.ConclusionIncreased cortisol in the CNS is associated with tau pathology and neurodegeneration, and with decreased insula and amygdala volume. Both CSF cortisol and DHEAS levels predict faster clinical disease progression. These results have implications for the identification of patients at risk of rapid decline as well as for the development of interventions targeting both neurodegeneration and clinical manifestations of AD.
Concurrent Tuberculous Meningoencephalitis and Anti-NMDAR Encephalitis: A Case Report
Authors: Xiaoli Chen , Qun Wang , Jing Li , Huan Yang , Si Chen 
Published: July 2022

BackgroundCases of tuberculosis triggering the development of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis are absent.Case PresentationHerein, we report, for the first time, the case of a patient who developed anti-NMDAR encephalitis likely due to tuberculosis. The patient, a 33-year-old man, experienced weight loss during the previous 2 years, along with acute headache, fever, cognitive deficits, and right ophthalmoplegia. Based on these findings and on data from magnetic resonance imaging and cerebrospinal fluid antibody analysis, tuberculous meningoencephalitis combined with anti-NMDAR encephalitis was diagnosed. Marked clinical and brain imaging improvement were observed after antituberculosis and high-dose corticosteroid treatment initiation, which persisted during the 3 months of follow-up.ConclusionsThis case suggests that anti-NMDAR encephalitis may arise after tuberculosis infection. Therefore, clinicians must be aware of this possibility, especially when cognitive and new neurological symptoms suddenly occur.