bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN MODUL PEMBELAJARAN BOTANICA-PROJECT UNTUK MENSTIMULASI MOTORIK HALUS ANAK USIA DINI
Authors: Jessica Sarah , Adhe Kartika Rinakit 
Published: March 2022

Kemampuan motorik halus pada anak usia 4-5 tahun sangat penting untuk dioptimalkan dan distimulasi dengan menerapkan metode yang tepat. Kematangan pada aspek motorik halus dapat meningkatkan keterampilan hidup seperti memakai dan mengancingkan baju sendiri, memakai sepatu sendiri, serta menyikat gigi, selain itu juga dapat membantu anak dalam menyelesaikan tugas di sekolah seperti menulis. Tujuan yang akan dicapai pada penelitian ini adalah untuk mengembangkan sebuah modul pembelajaran dengan metode Botanica-Project sebagai alternative pengembangan kegiatan motorik halus bagi anak usia 4-5 tahun serta mengetahui kelayakan dan keefektifan dari modul pembelajaran tersebut. Penelitian ini menggunakan jenis penelitian Research and Development (RD) dan mengacu pada model pengembangan 4D (Define, Design, Development, Dissemination). Data berupa penilaian mengenai kelayakan dan keefektifan modul pembelajaran Botanica-Project diperoleh dengan teknik angket atau kuesioner online dalam bentuk Google form. Hasil data yang diperoleh dari uji coba kelayakan dan keefektifan modul pada 30 guru TK di Surabaya menunjukkan nilai persentase sebesar 87% sehingga termasuk dalam kategori sangat baik. Adapun penilaian kelayakan modul dari ahli materi memperoleh nilai persentase sebesar 89% dan termasuk kategori sangat baik, selain itu penilaian yang dilakukan oleh ahli media memperoleh nilai persentase sebesar 85% dan dapat digolongkan dalam kriteria sangat baik. Berdasarkan hasil tersebut dapat disimpulkan bahwa modul pembelajaran Botanica-Project dinyatakan memenuhi standar kelayakan dan keefektifan dalam menstimulasi aspek motorik halus anak pada usia 4-5 tahun. Pengembangan modul pembelajaran Botanica-Project dapat menjadi inovasi bahan ajar bagi guru TK dalam rangka menstimulasi kemampuan motorik halus anak usia 4-5 tahun melalui kegiatan berkebun hidroponik yang dilakukan di luar ruangan.
STUDY KASUS KEMANDIRIAN ANAK DOWN SYNDROME USIA 8 TAHUN
Authors: Rahmatunnisa Sriyanti , Sari Diah Andika , Iswan Iswan , Bahfen Munifah , Rizki Fildzah 
Published: March 2022

Tujuan penelitian ini adalah untuk mengetahui kemandirian anak penyandang down syndrome yang orang tuanya tergabung dalam komunitas Persatuan Orang Tua Anak Dengan down syndrom. Penyandang down syndrome dianggap sulit untuk dilatih dan dibentuk kemandiriannya. Metode yang digunakan dalam penelitian ini adalah metode kualitatif deskriptif. Subjek penelitian ini adalah NN anak perempuan down syndrome usia 8 tahun dan GR anak laki-laki down syndrome usia 8 tahun. Penelitian ini dilakukan di Rumah Ceria Down Syndrome (RCDS) serta di kediaman NN dan GR. Hasil Penelitian menunjukkan bahwa anak down syndrome seperti NN dan GR, bisa mencapai kemandiriannya dengan baik, sesuai dengan potensi dan karakteristik khusus yang dimilikinya. Kemandirian NN dan GR ditinjau dari aspek fisik, intelektual, emosional dan sosial, seperti dapat merawat dan mengurus kebutuhan diri sendiri, disiplin, percaya diri, dapat mengikuti arahan sesuai instruksi, dan dapat menepati janji. Kemandirian NN dan GR dapat dicapai karena dukungan dari berbagai pihak, secara kolaboratif dan berkesinambungan, seperti dukungan Rumah Ceria Down Syndrome, pelatih musik djembe, orang tua, serta pendidik yang membiasakan dan mengembangkan kemandirian anak down syndrome dengan memfasilitasi dan memberikan kesempatan sesuai potensi yang dimiliki anak.
Source Parameters and Slip Distribution of the 2019 Mw 5.8 Mirpur (Pakistan) Earthquake Inferred from the Corrected InSAR Observations
Authors: Tan Ying , Dai Zhiyang , Liu Bin , Zha Xianjie 
Published: March 2022

AbstractOn 24 September 2019, an Mw 5.8 earthquake occurred on the Mangla-Samwal anticline near Mirpur city, Pakistan. Because the seismogenic fault is hidden and the near-field seismic data are scarce, the magnitude and slip distribution of this earthquake are not determined. Furthermore, due to small deformation and significant atmospheric noise in the coseismic interferograms, it is difficult to accurately determine source parameters and slip distribution using the original single ascending and descending Interferometric Synthetic Aperture Radar observations. In this article, we used Sentinel-1A satellite Synthetic Aperture Radar data to generate 60 ascending and 56 descending coseismic interferograms and performed atmospheric error correction including Kriging interpolation correction and displacement stacking to obtain more accurate coseismic displacement fields for the 2019 Mw 5.8 Mirpur earthquake. Considering the local geological structures, focal mechanism solutions, and the optimal fault parameters obtained from the coseismic displacement inversion, we determine that the strike and dip of the fault of the 2019 Mirpur earthquake are 296.3° and 4.0°, respectively. Based on this fault model, the fault plane was extended to 12.0 km long and 11.0 km wide and divided into subfaults of 1.0×1.0  km2. We inverted the coseismic displacement fields to obtain slip distribution on the fault plane. Slip is mainly distributed at a depth of 4.7 ∼ 5.0 km, with a maximum of 0.95 m at a depth of 4.88 km. The slip distribution shows that this earthquake was a thrust event with right-lateral strike-slip components, which is consistent with the focal mechanism solution from the U.S. Geological Survey. The estimated geodetic moment is about 7.14×1017  N·m, equivalent to Mw 5.8.
Developing ‘My Papa Darling’ As an English Teaching Media for Parts of Speech
Authors: Anisa Chusnul , . Wijayadi , Mayasari Linda 
Published: March 2022

Parts of Speech is one of the important elements that students should learn to master English grammar. This research aimed at developing ‘My Papa Darling’ as an English teaching media for part of speech. This research was conducted in 9th-grade students of SMP Negeri 58 Surabaya. In developing ‘My Papa Darling‘, this research adopted the model by Thiagarajan which is called Four-D (4D), it consists of four phases namely Define, Design, Develop, and Disseminate. Due to a limited time, this research stopped in field trials. After passing some phases, the data were gained. First, the media was valid since the score of the validity test was 3.5. Then the result of the observation checklist toward the implementation of media in the classroom obtained 3.8 which meant it was excellent. The students gave positive responses, which could be seen from the average score of the students’ questionnaire, 88.66%. In short, My Papa Darling is appropriate media to use in teaching and learning English in parts of speech.
Keywords: My Papa Darling, teaching media, parts of speech
Memory of Romanian Law. The Beginnings of Sibiu Law and Administrative Education
Authors: Tăvală Emanuel 
Published: March 2022

In 2021 the Law Faculty of the public University in Sibiu is celebrating 50 years of continuous activity starting with 1971. Actually, this institution is one of the oldest juridical teaching institutions in Romania, but not having in mind 1971, but the first institution which was inaugurated in 1844 and closed in 1887. This is why the 2021 moment of the Legal School in Sibiu is a moment of reflection and in the same time of revealing the whole history of this school which marked the legal history of Transylvania and the Romanian national history in the same time. In this study there are some of the starting information about how the Imperial legal faculty in Sibiu / Hermannstadt was opened and how it functioned under legal and administrative aspects. The information is taken from the archives in Sibiu and Vienna and from the few articles which were written in foreign languages about this institution.
The 2021 moment in the history of Sibiu law school brings with it the obligation of a reflection to situate this event, beyond a simple anniversary stop (counted now beginning with 1971, from the moment of its re-establishment) on the time scale and on the broader coordinates of the place and historical moments in the destiny of the Romanian nation, as well as Transylvanian public law and administration, whose specific dimensions and evolutions have shaped and reflected at the same time.
Presentation: Case No 6816/99/2015, Matter: Labour disputes, Procedural status of the Case: Merits, Subject Matter: Legal Interest, Civil Judgment no.315/2016 Delivered by Iaşi Court - Civil Division I, Complet: Civ. CM10
Authors: Anitei Nadia Cerasela 
Published: March 2022

By an action registered with the Court of Iasi under no. 6816/99/2015, the plaintiff ANC sued UDG, requesting that it be ordered to pay the transitional compensation (doctorate bonus) from 02.10.2012-present, with interest and penalties; with court costs.
In support of her action, the applicant submits the following:
"- order the defendant to pay the transitional compensation from 2 October 2012 - present with interest and related penalties;
- order the defendant to pay the costs."
Funkcjonowanie biblioteki Centralnego Muzeum Włókiennictwa w Łodzi podczas pandemii: od marca 2020 do sierpnia 2021 r.
Authors: Grabowska Justyna 
Published: March 2022

Celem niniejszego opracowania jest przedstawienie działalności Działu Biblioteka i Archiwum Centralnego Muzeum Włókiennictwa w Łodzi w okresie pandemii koronawirusa SARS-CoV-2. Podjęto w nim próbę odpowiedzi na pytanie, jaki wpływ wywarła światowa epidemia na pracę w bibliotece. Opisano zmianę sposobu pracy instytucji po decyzji o jej zamknięciu, omówiono realizację zadań biblioteki i archiwum zakładowego. Przedstawiono zasady bezpieczeństwa podczas korzystania z biblioteki po ponownym jej otwarciu oraz plany placówki na przyszłość.
Normal Walking Speed According to Age and Gender in Preliminary Students in Surabaya
Authors: Ananda Naoval Diza , Laswati Hening , Rejeki Purwo Sri , Suyoko Andri 
Published: March 2022

Background: Studies on walking have been developed recently because the speed of walking plays an important role in making predictions related to physical health. However, studies of walking speed in children are still relatively few even though the need for such data is quite high considering that walking speed can be used as a parameter to measure physicalhealth.Aim: The purpose of this study is to know the difference in walking speed based on age and gender in elementary school students.Methods: This study used an analytic observational study with a cross-sectional approach. All samples are students from Mojo VI State Elementary School Surabaya aged 7 to 12 years who meet the inclusion criteria using 10-meter walk test. The variable studied was walking speed. Method of sampling was conducted at Mojo VI State Elementary School Surabaya. Walking speed analysis was carried out by using the Kruskal-Wallis test for walking speed based on age and an unpaired T test for walking speed based on gender.Results: This research included 170 subjects that are 90 males and 80 males. Based on age, seven years old students have anaveragewalkingspeedof(1.30±0.21)m/s, eightyearsold students with(1.23±of0.18)m/s, nine yearsold students with (1.24 ± 0.17) m/s, ten years old students with (1.24 ± 0.19) m/s. eleven years old students with (1.31 ± 0.22) m/s, and twelve years old students with (1.27 ± 0.20) m/s. Based on gender, the average walking speed obtained in male was (1.26 ± 0.19) m/s, while the average walking speed obtained in female was (1.26 ± 0,20)m/s.Conclusion: There is no difference in the speed of walking based on age (p=0.440) at the age of 7 to 12 years and in both genders (p=0.910).
Expression of cytokine and apoptosis-related genes in murine macrophages and dendritic cells stimulated with Brucella melitensis recombinant proteins
Authors: Zhang Huan , Wang Yueli , Wang Yifan , Yi Jihai , Deng Xiaoyu , Ma Zhongchen , Li Honghuan , Yang Ningning , Li Zhiqiang , Sheng Jinliang , Wang Zhen , Wang Yong , Wang Yuanzhi , Chen Chuangfu 
Published: March 2022

Abstract
Background
Brucellosis, a zoonosis of public health and economic importance globally. Vaccination is the most efficient way to prevent the infection. Many protein antigens have been selected as diagnostic antigens recently, whereas, the exact mechanisms at the early stage of immune response are remain unknown. In this study, four Brucella melitensis cellular proteins were cloned, and the expressed recombinant proteins were purified. The expression of several cytokine genes (IFN-β, IFN-γ, IL-4, IL-10, IL-12p40, and TNF-α) was analyzed in a murine macrophage cell line (RAW264.7) and murine dendritic cells line(DCs) after stimulation with the recombinant proteins. Two apoptosis-related genes, Bax and Bcl-2, were also included in the analysis to find out the adverse effects of the proteins on the cells.
Results
Each protein induced a different pattern of cytokine expression depending on the antigen dose and cell type. The expression of Th1-type cytokine genes (IFN-γ, TNF-α, and IL-12p40), Th2-type cytokine genes (IL-10 and IL-4), and IFN-β were induced with all of the proteins in RAW264.7 and DCs. The expression of apoptosis-related genes (Bax and Bcl-2) was also induced with most of the proteins in RAW264.7 and DCs. Specifically, the expression of two apoptosis-related genes was not altered with OMP25 protein treatment in DCs; prpA, wadC, and RomA can induce apoptosis-related gene expression both in RAW264.7 cell and DCs.
Conclusions
These results suggest that the four recombinant antigens of B. melitensis can induce pro- or anti- inflammatory cytokine genes at the mRNA level and these changes should be confirmed at the protein level. OMP25 might be a promising antigen for developing a vaccine, but the immunogenicity needs to be further assessed in vivo.
Based on bioinformatics studies on the effect of alpha1H on key genes, pathways in bladder cancer and lncRNA on patient prognosis
Authors: Zhou Haiyong , Wang Xing , Yu Jiandi , Peng Kun , Wen Huali , Wang Renjie 
Published: March 2022

Abstract
Objective: To analyze the differential genes, lncRNA, signaling pathway and patient prognosis of bladder cancer after alpha1H treatment.Methods: Sequencing data GSE172112 for patients in clinical trials with a new bladder cancer drug were downloaded from the GEO database, The bladder cancer tissues using the new drug alpha1H (alpha1-oleate) and placebo (placebo) were analyzed in the R language, The differentially expressed genes were selected; Differential genes were analyzed for KEGG pathway enrichment using the DAVID database, To explore the effect of a lpha1H treatment on pathways in patients with bladder cancer; at the same time, lncRNA expression data from the Bladder Cancer (BLCA) dataset were also downloaded through the TCGA database, First, screening for differential lncRNA expression, The screening results were then analyzed by univariate Cox regression to initially screen for lncRNA associated with prognosis, The key lncRNA affecting the prognosis were further screened out, The prognostic model was also constructed using multivariate Cox regression analysis. Results: There yielded 394 significantly upregulated genes and 385 significantly downregulated genes in bladder cancer tissue after alpha1H treatment. Through gene signaling pathway enrichment analysis, the upregulated genes were mainly enriched in the signaling pathways regulating the pluripotent line of stem cell cells, the TGF-signaling pathways, and the cell cycle. The downregulated genes were mainly enriched in the MAPK signaling pathway, phagosomes, and the TNF signaling pathway. After alpha1H treatment, of 119 differentially expressed lncRNA, from the lnc2cancer database, two genes were found to be potentially associated with bladder cancer prognosis, and the final analysis confirmed the key lncRNA affecting prognosis. The results of survival analysis showed that high expression of LINC00152 unfavorable unfavorable patient prognosis and the new drug alpha1H reduces LINC00152 favors patient prognosis. Conclusion: Alpha1H can cure bladder cancer by regulating hallmark signaling, TGF-beta signaling, and LINC00152.
Catastrophic impact of multimorbidity on households in India: a cross-section analysis of self-reported morbidity from National Sample Survey 2017
Authors: Karan Anup , Farooqui Habib Hasan , Hussain Suhaib , Hussain Mohammad Akhtar , Selvaraj Sakthivel , Mathur Manu Raj 
Published: March 2022

Abstract
Background: The purpose of this research is to generate new evidence on economic consequences of multimorbidity on households in terms of out-of-pocket (OOP) expenditures and its catastrophic impact.Methods: We analyzed Social Consumption Health data from National Sample Survey Organization (NSSO) 75th round conducted in the year 2017-2018 in India. Prevalence of multimorbidity and related OOP expenditure were estimated. Using Coarsened Exact Matching (CEM) we estimated mean OOP expenditure for individuals reporting multimorbidity and single morbidity for each episode of outpatient visits and hospital admission. We also estimated the catastrophic impact of multimorbidity on households.Results: Our matched sample analysis suggests that that OOP expenditure is invariably lower in case of outpatient treatment of the selected Non Communicable Diseases(NCDs) whereas in case of hospitalization, the OOP expenditures were mostly higher for the same NCD conditions in the presence of multimorbidity as compared with single conditions, except for cancers and cardiovascular disease. Furthermore, around 46.7% (46.674 - 46.676)households reported incurring catastrophic spending (10% threshold) because of any NCD in standalone disease scenario which rose to 63.3% (63.359-63.361) under multimorbidity scenario. The catastrophic impact of cancer among the individual diseases was the highest.Conclusions: Implementing financial risk protection measures to reduce the burden of household OOP expenditure is required at the country level.
Quality of life and frailty outcomes following surgical and transcatheter aortic valve replacement
Authors: Surman Timothy Luke , Abrahams John Matthew , Kim Jaewon , Surman Hayley Elizabeth , Roberts-Thomson Ross , Montarello Joseph Matthew , Edwards James , Worthington Michael , Beltrame John 
Published: March 2022

Abstract
Background Our objective was to report on the prospective outcomes in the areas of depression, quality of life, angina, and frailty in SAVR and TAVR patients with aortic stenosis undergoing aortic valve intervention. Methods We recruited 300 patients across 3 groups (TAVR, SAVR, and CABG) over 12 months. Depression, quality of life, frailty, and angina were assessed followed by propensity score matching. ResultsUsing logistical regression when all patient factors considered for all patients who had SAVR and TAVR, the only preoperative factors that impacted on 1-year mortality was hypertension and STS score. Quality of life improvements within each group over 12 months was significant (p-value =0.0001). Depression at 12 months between groups (p-value =0.0395) and within each group was significant (p-value = 0.0073 for SAVR and 0.0001 for TAVR). Angina was most frequent in TAVR at 12 months in the QL (p=0.0001), PL (p=0.0007), and improvement was significant in the QL (SAVR p=0.0010, TAVR p= 0.0001) and PL (SAVR p=0.0002), TAVR p=0.0007) domains in both groups. Frailty at 12 months improved in both groups, but was greatest in TAVR (p-value = 0.00126). Conclusions This 12-month follow up of cardiac surgical patients has revealed significant improvement in PROMs and frailty in all groups by 3-months postoperative regardless of surgical or transcatheter approach. Outcome measures of quality of life and frailty should be utilized as a measure of outcome more regularly in patients undergoing aortic valve surgery regardless of approach.
Palliative care reduces emergency room visits and total hospital days among patients with metastatic HPB and GI cancers
Authors: Billiot Angelle A , Danos Denise M , Stevens Jenny , Vance Katie M , Raven Mary C , Lyons John M 
Published: March 2022

Abstract
Purpose: Palliative care services (PCS) have improved quality of life for patients across various cancer subtypes. Minimal data exists regarding the use of PCS for metastatic hepatopancreaticobiliary (HPB) and gastrointestinal (GI) malignancies. We assessed the impact of PCS on emergency department (ED) visits, hospital admissions, and survival among patients with these terminal malignancies.Methods: We identified all patients with metastatic HPB and GI malignancies referred to outpatient PCS for end-of-life care between 2014 and 2018. A subset of referred patients did not attend their appointment and did not receive PCS. We compared the demographics, outcomes, and end-of-life indicators between those who did and did not receive PCS. Results: 183 patients were referred for PCS. Most patients had metastatic colorectal (mCRC) (41%) or pancreatic (19.1%) cancers. 118 (64.5%) patients received PCS; 65 (35.5%) did not. No difference was noted in age, gender, race, marital status, or insurance coverage. Those receiving PCS were more likely to have mCRC (49.2% versus 26.2%, p = 0.0082) and were more likely to receive chemotherapy (80.5% versus 63.1%, p = 0.0098). On multivariate analysis, PCS was associated with fewer ED visits (p = 0.0319), hospital admissions (p = 0.0002), and total inpatient hospital days (p < 0.0001) per 30 days of life. Overall survival was greater among patients receiving PCS (HR = 0.65, 95% CI: 0.46-0.92).Conclusion: Outpatient PCS for patients with metastatic HPB and GI malignancies is associated with fewer ER visits, fewer hospital admissions, fewer inpatient hospital days, and improved overall survival.
Non Mucor Fungal Invasive Rhino Sinusitis with Ocular Signs in SARS Cov-2 Infection with Delta Variant (B.1.617.2) in India.
Authors: ambasta anita 
Published: March 2022

Abstract
Objective: To highlight fungi other than mucoromycetes as causative agent of invasive rhinosinusitis with ocular signs in recovered or concurrent covid 19 patients and identifying the presenting features, risk factors, intervention and outcomes.Method and analysis- Retrospective interventional study of seven patients with covid 19 who developed non mucor invasive rhinosinusitis with ocular involvement. Clinical presentation ,history and investigations analyzed. Management was by intravenous liposomal amphotericin B and functional endoscopic sinus surgery (FESS) with paranasal sinus debridement. Limited orbital debridement with or without transcutaneous retrobulbar liposomal amphotericin B(TRAMB) was done in patients with orbit involvement. Postoperative antifungal therapy was decided on basis of the causative fungi. Results- Four cases of Aspergillus and one each of Fusarium, Culvularia and Penicillium was seen .All patients had prominent periocular swelling and edema with pain and nasal stuffiness. Orbit involvement on MRI was seen in four cases: Partial third nerve palsy was seen in two and cavernous sinus thrombosis was seen in one with aspergillosis. Proptosis was not witnessed in any case. History of Diabetes and use of steroids was seen in all. All patients had mild to moderate covid with oxygen supplementation needed in one. No mortality , vision loss or exenteration happened. Conclusion: Secondary infection by Fungi other than mucoromycetes can be seen in covid 19. Timely surgical intervention and use of appropriate antifungals by correctly identifying causative fungi can lead to good prognosis.