bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1
Authors: Lucas Calixto-Hope G. , Sloan Emily A. , Gupta Rohit , Wu Jasper , Pratt Drew , Vasudevan Harish N. , Ravindranathan Ajay , Barreto Jairo , Williams Erik A. , Shai Anny , Whipple Nicholas S. , Bruggers Carol S. , Maher Ossama , Nabors Burt , Rodriguez Michael , Samuel David , Brown Melandee , Carmichael Jason , Lu Rufei , Mirchia Kanish , Sullivan Daniel V. , Pekmezci Melike , Tihan Tarik , Bollen Andrew W. , Perry Arie , Banerjee Anuradha , Mueller Sabine , Gupta Nalin , Hervey-Jumper Shawn L. , Oberheim Bush Nancy Ann , Daras Mariza , Taylor Jennie W. , Butowski Nicholas A. , de Groot John , Clarke Jennifer L. , Raleigh David R. , Costello Joseph F. , Phillips Joanna J. , Reddy Alyssa T. , Chang Susan M. , Berger Mitchel S. , Solomon David A. 
Published: August 2022

AbstractGliomas arising in the setting of neurofibromatosis type 1 (NF1) are heterogeneous, occurring from childhood through adulthood, can be histologically low-grade or high-grade, and follow an indolent or aggressive clinical course. Comprehensive profiling of genetic alterations beyond NF1 inactivation and epigenetic classification of these tumors remain limited. Through next-generation sequencing, copy number analysis, and DNA methylation profiling of gliomas from 47 NF1 patients, we identified 2 molecular subgroups of NF1-associated gliomas. The first harbored biallelic NF1 inactivation only, occurred primarily during childhood, followed a more indolent clinical course, and had a unique epigenetic signature for which we propose the terminology “pilocytic astrocytoma, arising in the setting of NF1”. The second subgroup harbored additional oncogenic alterations including CDKN2A homozygous deletion and ATRX mutation, occurred primarily during adulthood, followed a more aggressive clinical course, and was epigenetically diverse, with most tumors aligning with either high-grade astrocytoma with piloid features or various subclasses of IDH-wildtype glioblastoma. Several patients were treated with small molecule MEK inhibitors that resulted in stable disease or tumor regression when used as a single agent, but only in the context of those tumors with NF1 inactivation lacking additional oncogenic alterations. Together, these findings highlight recurrently altered pathways in NF1-associated gliomas and help inform targeted therapeutic strategies for this patient population.
The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review
Authors: Almohammadi Abdulla , Raveendran Ainharan , Black Mairead , Maheshwari Abha 
Published: August 2022

Abstract
Objective
To investigate the optimal route of progesterone administration for luteal phase support in a frozen embryo transfer.

Design
Systematic review.

Patients
Women undergoing frozen embryo transfer (FET).

Interventions
We conducted an extensive database search of Medline (PubMed), Embase, Web of Science, and Cochrane Trials Register using relevant keywords and their combinations to find randomized controlled trials (RCTs) comparing the routes (i.e., oral, vaginal, intramuscular) of progesterone administration for luteal phase support (LPS) in artificial FET.

Main outcome measures
Clinical pregnancy, live birth, miscarriage.

Results
Four RCTs with 3245 participants undergoing artificial endometrial preparation (EP) cycles during FET were found to be eligible. Four trials compared vaginal progesterone with intramuscular progesterone and two trials compared vaginal progesterone with oral progesterone. One study favored of vaginal versus oral progesterone for clinical pregnancy rates (RR 0.45, 95% CI 0.22–0.92) and other study favored intramuscular versus vaginal progesterone for clinical pregnancy rates (RR 1.46, 95% CI 1.21–1.76) and live birth rates (RR 1.62, 95% CI 1.28–2.05). Tabulation of overall evidence strength assessment showed low-quality evidence on the basis that for each outcome-comparison pair, there were deficiencies in either directness of outcome measurement or study quality.

Conclusion
There was little consensus and evidence was heterogeneous on the optimal route of administration of progesterone for LPS during FET in artificial EP cycles. This warrants more trials, indirect comparisons, and network meta-analyses.

PROPERO No
CRD42021251017.
Willingness, preferences, barriers, and facilitators of a multimodal supportive care intervention including exercise, nutritional and psychological approach in patients with cancer: a cross-sectional study
Authors: Avancini Alice , Trestini Ilaria , Tregnago Daniela , Belluomini Lorenzo , Sposito Marco , Insolda Jessica , Schena Federico , Milella Michele , Pilotto Sara 
Published: August 2022

Abstract
Purpose
Supportive care, including exercise, nutritional and psychological support, is becoming increasingly important in cancer given their impact on ‘patients’ quality and quantity of life. The purpose of this study was to explore willingness, preferences barriers and facilitators for a multimodal intervention in patients with cancer.

Methods
An anonymous questionnaire was proposed on randomly selected days to the patients visiting the cancer outpatients’ facilities at the Oncology Unit of the University Hospital of Verona. The questionnaire investigated willingness, preferences, barriers, and facilitators associated with participation in a multimodal program designed for patients with cancer. Exercise level was estimated using two open questions, nutritional risk was identified using the Nutritional Risk Screening 2002, while distress was evaluated with the Distress Thermometer.

Results
Based on 324 participants, 65% were interested in starting a multimodal intervention. Patients declared to prefer to receive instructions from dedicated experts, with a face-to-face approach, and during the anticancer treatment. Treatment-related side effects were the major obstacles for a multimodal program, while the availability of a specialized staff as exercise kinesiologists, dietitians, and psycho-oncologists was found to be an important facilitator for increasing ‘patients’ participation.

Conclusion
Patients patients with cancer are interested in participating in a multimodal supportive care program specifically designed for them. Information from this study may help to design a tailored multimodal intervention for patients with cancer.
Plasma transthyretin is a nutritional biomarker in human morbidities
Authors: Ingenbleek Yves 
Published: August 2022

AbstractTransthyretin (TTR) is a small liver-secreted plasma protein that shows close correlations with changes in lean body mass (LBM) during the entire human lifespan and agglomerates the bulk of nitrogen (N)-containing substrates, hence constituting the cornerstone of body building. Amino acids (AAs) dietary restriction causes inhibition of TTR production and impairs the accretion of LBM reserves. Inflammatory disorders result in cytokine-induced abrogation of TTR synthesis and urinary leakage of nitrogenous catabolites. Taken together, the data indicate that malnutrition and inflammation may similarly suppress the production of TTR through distinct and unrelated pathophysiological mechanisms while operating in concert to downsize LBM stores. The hepatic synthesis of TTR integrates both machineries, acting as a marker of reduced LBM resources still available for defense and repair processes. TTR operates as a universal surrogate analyte that allows for the grading of residual LBM capacity to reflect disease burden. Measurement of TTR is a simple, rapid, and inexpensive micro-method that may be reproduced on a daily basis, hence ideally suited for the follow-up of the most intricated clinical situations and as a reliable predictor of any morbidity outcome.
Technical Methods for Social Robots in Museum Settings: An Overview of the Literature
Authors: Hellou Mehdi , Lim JongYoon , Gasteiger Norina , Jang Minsu , Ahn Ho Seok 
Published: August 2022

AbstractRobots have become increasingly present in our daily lives, and we see several settings wherein this technology might positively impact people. One of these settings, and the focus of this paper, is the museum. This paper provides an overview of the literature on how robots can help people within the museum context and explores the state-of-the-art methods or technologies employed by researchers to allow robots to interact within this environment. Five key features were found to be essential to integrate into social museum robots: social navigation (including safe and successful motions); perception (how robots can use visual skills to understand the environment); speech (verbal communication with visitors); gestures (non-verbal cues) and behavior generation (how the robot combines the four skills to adopt different behaviors). The paper subsequently analyzes the integration of these features into robotic systems for a complete and appropriate collection of behaviors in the museum setting.
Implications of Magnetic Properties in the Concentration and Distribution of REEs in Beach Placer Monazites: A Case Study from Chhatrapur Coast, Odisha
Authors: Yugandhara Rao A. , Panda Niroj K. , Ramesh Kumar K. , Sinha D.K. 
Published: August 2022

Abstract
The concentration of monazite, a rare earth and thorium phosphate, in the heavy mineral-bearing sands of Chhatrapur coast varies from 0.09 to 0.16%. Under the microscope, monazite displays color variation from colorless to various shades of yellow, green and brown. The color variation is further reflected in the chemistry of individual grains. Such monazites of distinct colors and different chemistry also show variation in their paramagnetic properties. Representative detrital monazites separated under varied magnetic field strength were analysed for their rare earth elements, Th and U content. The electron probe micro analysis (EPMA) data indicate that monazites separated under low magnetic field strength (separated at 0.80 amps) are characterized by their higher Nd, Sm, HREE, Y and U as well as low Th content, whereas those separated at 1.10 amps contain low Nd, Sm, HREE with negligible Y and U content as well as higher Th content. The wider variation in the concentration of different rare earths in varied magnetic field strength is a function of varied magnetic susceptibility of individual elements. Hence, the physical method for separation of monazite using magnetic properties may facilitate to segregate the monazites of a particular chemical composition with respect to their constituent elements like U, Th and rare earths based on their magnetic properties.
L718Q/V mutation in exon 18 of EGFR mediates resistance to osimertinib: clinical features and treatment
Authors: Li Meihui , Qin Jing , Xie Fajun , Gong Lei , Han Na , Lu Hongyang 
Published: August 2022

AbstractOsimertinib, a mutant-specific third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), is emerging as the preferred first-line of treatment for EGFR-mutant lung cancer. However, osimertinib resistance inevitably develops among patients treated with the drug. The modal resistance mechanisms of osimertinib include the occurrence of epithelial transition factor (c-MET) amplification and C797S mutation, whereas rare mutations are presented as case reports. Recently, the L718Q/V mutation in exon 18 of EGFR has been reported to contribute to one of the possible mechanisms of resistance. The clinical features and subsequent treatment strategies for this mutation require further research. This study retrospectively enrolled NSCLC patients with the L718Q/V mutation from 2017 to 2021 at the Cancer Hospital of the University of the Chinese Academy of Sciences (Zhejiang Cancer Hospital), as well as additional patients with the same mutation from PubMed literature, to summarize the clinical features of the mutation. The association between the detection of L718Q/V and resistance to osimertinib, as well as impacts on the therapeutic process and outcome, was analyzed. We included a total of two patients diagnosed at Zhejiang Cancer Hospital and twelve patients from the literature. Of the fourteen total patients, 64.3% were male and 35.7% were female. The average age of the group was 60.2 years (range 45–72). A history of tobacco use was common among the group. In all of the cases we considered, the L718Q/V mutation was secondary to the L858R mutation. The second-generation TKI afatinib was found to provide a high disease control rate (DCR) (85.7%, 6/7) and relatively low objective response rate (ORR) (42/9%, 3/7). The median progression free survival (mPFS) for this treatment reached 2 months (1–6 months). The patients failed to benefit from chemotherapy combined with immunotherapy or other TKI medications. Due to the limited number of cases considered in this study, future studies should explore drugs that more precisely target the L718Q/V mutation of EGFR exon 18.
„Möchten Sie uns abschließend noch etwas mitteilen?“ – Auswertung der offenen Abschlussfrage in einem sozialwissenschaftlichen Survey
Authors: Boscher Claudia , Steinle Johannes , Raiber Lea , Fischer Florian , Winter Maik H. -J. 
Published: August 2022

Zusammenfassung
Hintergrund
Surveys schließen häufig mit einer offenen Abschlussfrage. Obwohl diese sich als multifunktionaler Bestandteil von Befragungen etabliert hat, wird sie selten ausgewertet. Dabei ermöglicht sie Erkenntnisgewinn im Hinblick auf methodische und inhaltliche Aspekte.

Ziel
Es wird anhand eines pflegewissenschaftlichen Surveys untersucht, inwiefern die Befragten in der offenen Abschlussfrage Themen aus dem Fragebogen erneut aufgreifen und für welchen Zweck sie diese Frage nutzen.

Methodik
Datenbasis ist eine repräsentative Querschnittsbefragung zu den Vorstellungen von „guter“ Pflege und pflegerischer Versorgung von 65- bis 75-Jährigen. Den schriftlichen Fragebogen, bestehend aus geschlossenen bzw. Hybridfragen, beantworteten 25 % der 2500 Befragten. Die offene Abschlussfrage wurde mithilfe der inhaltlich-strukturierenden qualitativen Inhaltsanalyse ausgewertet.

Ergebnisse
Die Abschlussfrage wurde von 23,4 % (n = 146) der Befragten beantwortet. Die meisten nutzten die Abschlussfrage für themenbezogene und persönliche Ausführungen. Thematisch stellen Angaben zum Gesundheitszustand die größte Subkategorie dar. Zudem wird über Pflegevorerfahrungen sowie über Wünsche und Sorgen mit Blick auf eine eigene Pflegebedürftigkeit berichtet.

Schlussfolgerung
Die vergleichsweise hohe Item-Response-Rate deutet auf das Bedürfnis hin, über persönliche Erfahrungen zu berichten. Die häufigen Äußerungen zum Gesundheitszustand könnten auf einen Reihenfolgeeffekt hindeuten, da Fragen zu Gesundheit und Lebensqualität das Ende des Fragebogens bildeten.
The Potential of Cell Sheet Technology for Beta Cell Replacement Therapy
Authors: Hermanns Carolin , da Silva Filho Omar Paulino , Vaithilingam Vijayganapathy , van Apeldoorn Aart 
Published: August 2022

Abstract
Purpose of Review
Here, we review the use of cell sheet technology using different cell types and its potential for restoring the extracellular matrix microenvironment, perfusion, and immunomodulatory action on islets and beta cells.

Recent Findings
Cell sheets can be produced with different fabrication techniques ranging from the widely used temperature responsive system to the magnetic system. A variety of cells have been used to produce cell sheets including skin fibroblasts, smooth muscle cells, human umbilical vein endothelial cells, and mesenchymal stem cells.

Summary
CST would allow to recreate the ECM of islets which would provide cues to support islet survival and improvement of islet function. Depending on the used cell type, different additional supporting properties like immunoprotection or cues for better revascularization could be provided. Furthermore, CST offers the possibility to use other implantation sites than inside the liver. Further research should focus on cell sheet thickness and size to generate a potential translational therapy.
Political Fragmentation and Coalition Alignment effects: Evidence from health Transfers to Italian Regions
Authors: Auteri Monica , Cattel Alessandro 
Published: August 2022

AbstractDo government parties positively discriminate in favor of swing or aligned sub-national units while allocating public resources? This paper integrates these two strands of the literature and makes a new contribution by incorporating the insightful perspective of the political fragmentation approach. Using a dataset of Italian regions between 2001 and 2011 constructed from primary sources and a new index of fractionalization, based on Golosov (Party Politics 16(2):171–192), we empirically find that it is the fragmentation of the aligned recipient government that affects the final amount of resources, rather than the alignment itself. Quasi-formula-based grants do not remove the arbitrariness that allows for politically motivated targeting.
Pharmaceutical markets in Japan and the United States
Authors: Comanor William S. 
Published: August 2022

AbstractAlthough the United States and Japan are the two largest markets for branded pharmaceuticals, their structures and market performance are quite different. Like its European counterparts, a Japanese government ministry sets the prices paid to national and international drug companies. In contrast, US prices are set largely through negotiations between private health insurers and drug companies. Related to these different structures are quite different results. In particular, for pharmaceuticals sold in both countries, US prices are about twice what they are in Japan. Since many of the same companies sell pharmaceuticals in both countries, these differences require an explanation. A frequent one offered is that Japanese authorities exercise their inherent monopsony power to obtain the low prices, which private insurers in the United States are unable to impose. While correct on the surface, this explanation fails to confront deeper policy issue concerned with promoting public health. Because pharmaceutical research and development is a global public good, there are strong incentives for buyers to “free ride” on the outlays of others. Under those circumstances, global R&D outlays, based on country-specific incentives, would be set below optimal levels, and the supply price of substantial pharmaceutical innovation would not be covered. Because the US market is more than half the world total, its incentive structure is fundamentally different from that of Japan. Indeed, higher US drug prices, which drive worldwide incentives, are needed to promote current numbers of new pharmaceuticals introduced in both countries.
Evaluating R&D efficiency of China’s listed lithium battery enterprises
Authors: Bai Shizhen , Bi Xinrui , Han Chunjia , Zhou Qijun , Shang Wen-Long , Yang Mu , Wang Lin , Ieromonachou Petros , He Hao 
Published: August 2022

AbstractPromoting the growth of the lithium battery sector has been a critical aspect of China’s energy policy in terms of achieving carbon neutrality. However, despite significant support on research and development (R&D) investments that have resulted in increasing size, the sector seems to be falling behind in technological areas. To guide future policies and understand proper ways of promoting R&D efficiency, we looked into the lithium battery industry of China. Specifically, data envelopment analysis (DEA) was used as the primary approach based on evidence from 22 listed lithium battery enterprises. The performance of the five leading players was compared with that of the industry as a whole. Results revealed little indication of a meaningful improvement in R&D efficiency throughout our sample from 2010 to 2019. However, during this period, a significant increase in R&D expenditure was witnessed. This finding was supported, as the results showed that the average technical efficiency of the 22 enterprises was 0.442, whereas the average pure technical efficiency was at 0.503, thus suggesting that they were suffering from decreasing returns to scale (DRS). In contrast, the performance of the five leading players seemed superior because their average efficiency scores were higher than the industry’s average. Moreover, they were experiencing increasing scale efficiency (IRS). We draw on these findings to suggest to policymakers that supporting technologically intensive sectors should be more than simply increasing investment scale; rather, it should also encompass assisting businesses in developing efficient managerial processes for R&D.
Repetitive transcranial direct current stimulation modulates the brain–gut–microbiome axis in obese rodents
Authors: Ziomber-Lisiak Agata , Talaga-Ćwiertnia Katarzyna , Sroka-Oleksiak Agnieszka , Surówka Artur D. , Juszczak Kajetan , Szczerbowska-Boruchowska Magdalena 
Published: August 2022

Abstract
Background
Complex interactions between the brain, gut and adipose tissue allow to recognize obesity as a neurometabolic disorder. The recent data have shown that gut microbiota can play a potential role in obesity development. Transcranial direct current stimulation (tDCS) is a safe and non-invasive technique to modulate the activity of cerebral cortex and other connected brain areas also in context of appetite control. The objective of this study was to evaluate the effects of repetitive anodal tDCS (AtDCS) of prefrontal cortex on feeding behavior, metabolic status and selected phyla of gut microbiota in rats with obesity induced by high-calorie diet (HCD).

Methods
32 female Wistar rats were equally divided into 4 subgroups depending on diet effect (lean versus obese) and type of stimulation (active versus sham tDCS versus no stimulation). Feed intake, body weight, blood lipoproteins and leptin levels as well as Firmicutes and Bacteroidetes in intestines and stool were examined.

Results
HCD changed feeding behavior and metabolic parameters typically for obesity-related ranges and resulted in an abundance of Firmicutes at the expanse of Bacteroidetes in the large intestine and stool. AtDCS decreased appetite, body weight, and cholesterol levels. In addition, AtDCS reduced ratio of the average number of Firmicutes to average number of Bacteroidetes in all examined tissues.

Conclusions
Repetitive AtDCS is not only effective for appetite restriction but can also modulate gut microbiome composition which demonstrates the existence of the brain–gut–microbiome axis and points at this technique as a promising complementary treatment for obesity. However, the effects should be further replicated in human studies.
Discerning preschool teacher’s experiences to enhance children’s participation in mathematical play activities
Authors: Svensson Christina 
Published: August 2022

AbstractThis study analyses teachers’ discernment of children’s mathematical knowledge development during preschool play activities and defines how children’s pre-knowledge supports or limits their learning possibilities. In total, two preschool teachers from different preschools participated in this research study. The data consists of two documentations of children’s activities, written notes, and reflections from these two participated preschool teachers. The teachers chose the samples and defined them as important examples of how to merge mathematical knowledge development in free play. Using variation theory, the focus was to define what aspects of children’s mathematical knowledge development were offered and how teachers discern children’s pre-knowledge. The results show how the preschool teachers discern children’s pre-mathematical knowledge in relation to development of abstract abilities, and the importance of identifying their participation in free play situations for promoting mathematical understanding.