bluuebunny/crossref_metadata_2025_split huggingface dataset:
Etiopathogenic features of severe epistaxis in histological samples from individuals with or without arterial hypertension
Authors: Rezende Gustavo Lara , Oliveira Leonel Alves , Soares Renata Oliveira , Carneiro Fabiana Pirani , Nakanishi Marcio , Baó Sônia Nair , Sampaio André Luiz Lopes , Kückelhaus Selma Aparecida Souza 
Published: January 2022

AbstractThere is a consensus that arterial hypertension (AH) is associated with stroke. Therefore, this study aimed to evaluate the histology of the microvasculature associated with the mucosa of the posterior nasal cavity to identify possible factors related to vascular weakening and rupture. Histological sections were obtained from hypertensive and normotensive individuals, regardless of epistaxis. Our results showed that the group with AH had: (a) smaller median diameter of the lumen of arteries and arterioles; (b) increased thickness of the intimal arteries and arterioles, slight inflammatory infiltrate, and rupture of internal elastic lamina; (c) greater thickness of the middle tunica in arterioles; (d) lower percentage of histological sections with non-injured intimal layers in capillaries, arterioles, and small arteries; (e) lower percentage of histological sections with intact media tunic and/or myocytes juxtaposed in arteries and arterioles; (f) no difference between the diameters of small arteries or arterioles. The intima was thicker in individuals with severe epistaxis than in the normotensive group, but it did not differ from the AH group. Thus, hypertension may cause structural lesions in the vascular layers, and in the absence of tissue repair and the persistence of AH, these lesions may favour vascular rupture, especially during hypertensive peaks.
Cold shock induces a terminal investment reproductive response in C. elegans
Authors: Gulyas Leah , Powell Jennifer R. 
Published: January 2022

AbstractChallenges from environmental stressors have a profound impact on many life-history traits of an organism, including reproductive strategy. Examples across multiple taxa have demonstrated that maternal reproductive investment resulting from stress can improve offspring survival; a form of matricidal provisioning when death appears imminent is known as terminal investment. Here we report a reproductive response in the nematode Caenorhabditis elegans upon exposure to acute cold shock at 2 °C, whereby vitellogenic lipid movement from the soma to the germline appears to be massively upregulated at the expense of parental survival. This response is dependent on functional TAX-2; TAX-4 cGMP-gated channels that are part of canonical thermosensory mechanisms in worms and can be prevented in the presence of activated SKN-1/Nrf2, the master stress regulator. Increased maternal provisioning promotes improved embryonic cold shock survival, which is notably suppressed in animals with impaired vitellogenesis. These findings suggest that cold shock in C. elegans triggers terminal investment to promote progeny fitness at the expense of parental survival and may serve as a tractable model for future studies of stress-induced progeny plasticity.
Similar experimental study on retaining waterproof coal pillar in composite strata mining
Authors: Wang Y. Q. , Wang X. , Zhang J. S. , Yang B. S. , Zhu W. J. , Wang Z. P. 
Published: January 2022

AbstractNumerous field examples of coal seam mining show that when coal seams under confined water are mined close to faults, water inrush effects on complex mining surfaces occur. Obeying similarity rules, physical similarity models consisting of sand, lime, and plaster were used to investigate the water conducting process, along with stress and displacement measured by a combination of mechanical senor, total station, and video camera-. Comparing the physical model tests with the calculation results of elastoplastic limit equilibrium theory, the rationality of the model has been verified. Besides, a safe width of the waterproof coal pillar has been obtained. It can be demonstrated from the model observations that the coal seam in front of the mining can be divided into three areas with different characteristics of stress and displacement, namely, which are the fault-affected area, the elastic area, and the plastic yield crack area. A closed-loop water inlet and outlet pipeline composed of a water control platform that can provide stable water pressure, and water bags pre-buried in the fault was used to simulate the water conduction in the fracture zone. Integrate the development law of stress, displacement, and water conduction coming from the upper and lower walls of the fault to further determine the reasonable width of the waterproof coal pillar.
Prognostic impact of miR-34b/c DNA methylation, gene expression, and promoter polymorphism in HPV-negative oral squamous cell carcinomas
Authors: Supic Gordana , Stefik Debora , Ivkovic Nemanja , Sami Ahmad , Zeljic Katarina , Jovic Sasa , Kozomara Ruzica , Vojvodic Danilo , Stosic Srboljub 
Published: January 2022

AbstractMicro RNAs (miRNAs) have a key role in gene expression regulation in cancer. The aim of the current study is to evaluate the prognostic value of miR-34b/c promoter hypermethylation, gene expression, and polymorphism in HPV-negative oral squamous cell carcinomas (OSCC). MiR-34b/c promoter hypermethylation and pre-miR-34b/c polymorphism rs4938723 were evaluated in tumor tissues of 148 patients, and miR-34b expression in 123 HPV-negative OSCC. For risk assessment, the control group was comprised of 175 healthy individuals. MiR-34b/c promoter hypermethylation was determined by methylation-specific PCR. Gene expression, genotyping and HPV screening was assessed by Q-PCR. The data from our hospital cohort indicated that miR-34b/c DNA methylation was associated with nodal status (p = 0.048), and predicted the shorter overall survival of HPV-negative OSCC patients (p = 0.008). Down-regulated miR-34b/c expression was associated with smoking (p = 0.047), alcohol use (p = 0.009), stage (p = 0.025), recurrences (p = 0.000), and a poor survival (p = 0.00029). Median values of miR-34b expression were significantly lower in advanced stages III/IV as opposed to stage I/II, p = 0.006, and in nodal positive vs negative patients (p = 0.045). TCGA data also indicated that tumors with stage I–III expressed significantly higher levels of miR-34b, compared to tumors with stage IV (p = 0.035), Low miR-34b/c expression was associated with poor survival in smokers (p = 0.001) and patients with tongue carcinomas (p = 0.00003), and TCGA analysis confirmed these findings although miR-34b expression and miR-34b/c methylation were not associated with survival outcome in the whole TCGA cohort. A significant negative miR-34b/c expression–methylation correlation was observed in our hospital cohort (p = 0.017) and in TCGA cohort. Pre-miR-34b/c polymorphism was not associated with oral cancer risk. Our findings indicate that miR-34b/c hypermethylation and low miR-34b expression could promote the progression and predict the poor prognosis for HPV-negative OSCC, which suggests miR-34b/c as a promising biomarker and therapeutic target for OSCC in the future.
Novel gene rearrangement in the mitochondrial genome of Anastatus fulloi (Hymenoptera Chalcidoidea) and phylogenetic implications for Chalcidoidea
Authors: Yi Jiequn , Wu Han , Liu Jianbai , Li Jihu , Lu Yinglin , Zhang Yifei , Cheng Yinjie , Guo Yi , Li Dunsong , An Yuxing 
Published: January 2022

AbstractThe genus Anastatus comprises a large group of parasitoids, including several biological control agents in agricultural and forest systems. The taxonomy and phylogeny of these species remain controversial. In this study, the mitogenome of A. fulloi Sheng and Wang was sequenced and characterized. The nearly full-length mitogenome of A. fulloi was 15,692 bp, compromising 13 protein-coding genes (PCGs), 2 rRNA genes, 22 tRNA genes and a control region (CR). The total A + T contents were 83.83%, 82.18%, 87.58%, 87.27%, and 82.13% in the whole mitogenome, 13 PCGs, 22 tRNA genes, 2 rRNA genes, and CR, respectively. The mitogenome presented negative AT skews and positive GC skews, except for the CR. Most PCGs were encoded on the heavy strand, started with ATN codons, and ended with TAA codons. Among the 3736 amino acid-encoding codons, TTA (Leu1), CGA (Arg), TCA (Ser2), and TCT (Ser2) were predominant. Most tRNAs had cloverleaf secondary structures, except trnS1, with the absence of a dihydrouridine (DHU) arm. Compared with mitogenomes of the ancestral insect and another parasitoid within Eupelmidae, large-scale rearrangements were found in the mitogenome of A. fulloi, especially inversions and inverse transpositions of tRNA genes. The gene arrangements of parasitoid mitogenomes within Chalcidoidea were variable. A novel gene arrangement was presented in the mitogenome of A. fulloi. Phylogenetic analyses based on the 13 protein-coding genes of 20 parasitoids indicated that the phylogenetic relationship of 6 superfamilies could be presented as Mymaridae + (Eupelmidae + (Encyrtidae + (Trichogrammatidae + (Pteromalidae + Eulophidae)))). This study presents the first mitogenome of the Anastatus genus and offers insights into the identification, taxonomy, and phylogeny of these parasitoids.
T cell subtype profiling measures exhaustion and predicts anti-PD-1 response
Authors: Schillebeeckx Ian , Earls Jon , Flanagan Kevin C. , Hiken Jeffrey , Bode Alex , Armstrong Jon R. , Messina David N. , Adkins Douglas , Ley Jessica , Alborelli Ilaria , Jermann Philip , Glasscock Jarret I. 
Published: January 2022

AbstractAnti-PD-1 therapy can provide long, durable benefit to a fraction of patients. The on-label PD-L1 test, however, does not accurately predict response. To build a better biomarker, we created a method called T Cell Subtype Profiling (TCSP) that characterizes the abundance of T cell subtypes (TCSs) in FFPE specimens using five RNA models. These TCS RNA models are created using functional methods, and robustly discriminate between naïve, activated, exhausted, effector memory, and central memory TCSs, without the reliance on non-specific, classical markers. TCSP is analytically valid and corroborates associations between TCSs and clinical outcomes. Multianalyte biomarkers based on TCS estimates predicted response to anti-PD-1 therapy in three different cancers and outperformed the indicated PD-L1 test, as well as Tumor Mutational Burden. Given the utility of TCSP, we investigated the abundance of TCSs in TCGA cancers and created a portal to enable researchers to discover other TCSP-based biomarkers.
Tracking the redox reaction-induced reconstruction of NiAu nanoparticles via environmental scanning transmission electron microscopy
Authors: Hao Ming , Li Hao , Liu Wei , Ma Tianyi , Liang Jinsheng , Sun Kai , Matsumoto Hiroaki , Wang Fei 
Published: January 2022

In situ electron microscopy discloses atmosphere-dependent reconstruction of NiAu catalyst. The oxidation converts Ni–Au dumbbell into Ni@Au@NiO, while Ni@NiAu alloy forms under H2 reduction and exhibits better activity towards CO–NO reaction.
Contributions of Counseling and Sound Generator Use in Tinnitus Retraining Therapy: Treatment Response Dynamics Assessed in a Secondary Analysis of a Randomized Trial
Authors: Formby Craig , Yang Xin , Scherer Roberta W. 
Published: January 2022

Purpose:
Tinnitus retraining therapy (TRT) has been widely used for 30 years, but its efficacy and the component contributions from counseling and sound therapy remain controversial. The purpose of this secondary analysis from the Tinnitus Retraining Therapy Trial (TRTT) was to compare treatment response dynamics for TRT (counseling and conventional sound generators) with partial TRT (pTRT; counseling and placebo sound generators) and standard of care (SOC; a patient-centered counseling control).

Method:

The TRTT randomized 151 participants with primary tinnitus (
no significant hearing or sound tolerance problems
) to TRT, pTRT, or SOC, each of which encouraged use of enriched environmental sound. The primary outcome, mean change in Tinnitus Questionnaire score assessed at baseline and follow-up across 18 months, was normalized for a common baseline and fitted with an exponential model. Time constants were estimated to quantify and compare the treatment response dynamics, which were evaluated for statistical significance using bootstrap analyses.

Results:

The change in response to TRT took less time to achieve than that for either pTRT or SOC, as demonstrated by time for normalized Tinnitus Questionnaire scores to decline to 63% and 99% of baseline TRT values: 1.2 months (95% CI [0.2, 1.9]) and 5.7 months (95% CI [0.9, 9.0]), respectively. Corresponding SOC values were 2.7 months (95% CI [1.5, 4.1]) and 12.4 months (95% CI [6.9, 19.0]), while those for pTRT were 2.2 months (95% CI [1.2, 3.4]) and 10.1 months (95% CI [5.7, 15.9]). The differences were significant for TRT versus SOC (
p
= .020), borderline significant for TRT versus pTRT (
p
= .057), but nonsignificant for pTRT versus SOC (
p
= .285). The magnitude of the asymptotic treatment response did not differ significantly among groups.

Conclusion:
Sound generator use in TRT increases treatment efficiency (beyond any advantage from enriched environmental sound) without affecting treatment efficacy (determined by counseling).
Clinical Impact Requires Clinical Practice Research
Authors: Utianski Rene L. , Spencer Trina D. , Wallace Sarah E. 
Published: January 2022

Purpose:
The extent to which research impacts clinical practice is directly related to the availability, accessibility, and relevance of clinical practice research (CPR). The purpose of this article is to describe some of the current barriers to CPR in communication sciences and disorders and review the resources available to support clinical practice researchers.

Results:
Considerations related to CPR are numerous and relate to its availability, relevance, and accessibility. There are longstanding challenges with the CPR pipeline, which include challenges getting researchers involved in conducting CPR, acquisition of funding to support CPR grant proposals, recognition of the validity and role of less traditional research paradigms in which some CPR is conducted, and publishing and disseminating CPR. The American Speech-Language-Hearing Association (ASHA) has developed a number of resources to support the development, execution, dissemination, and utilization of CPR in speech-language pathology and audiology.

Conclusions:
Clinicians, researchers, and clinician-scientists alike are encouraged to explore ASHA's CPR resources and initiatives. The outcomes of ASHA programs are encouraging in that researchers who participate in CPR initiatives are largely successful in obtaining funding for CPR. This is promising evidence that the availability, relevance, and accessibility barriers to CPR can be mitigated, which will ultimately lead to improved uptake and impact of CPR.
Federated learning over wireless backhaul for distributed micro‐Doppler radars: Deep learning aided gradient estimation
Authors: Yang Yunji , Hong Yong‐gi , Park Jaehyun 
Published: January 2022

AbstractWhen micro‐Doppler (MD) radars are distributed, a federated learning strategy over wireless backhaul links is developed for motion classification. Specifically to identify the human motion, a common convolutional neural network (CNN) model is shared for all the distributed radars (i.e. clients) and it is trained through the federated learning strategy over wireless backhaul connected to the main server. In the proposed system, a main bottleneck is the estimation of local gradients for CNN training at the server, which are transferred from distributed radars over the wireless backhaul link. To overcome it, a deep learning (DL) aided gradient estimation algorithm is proposed, in which the deep neural networks (DNNs) for encoding local gradient vectors at the distributed radars and the DNN for decoding (i.e. estimating) them at the server are jointly trained in an end‐to‐end autoencoder‐based learning strategy. To avoid the inter‐client interference over the wireless backhaul link, the DNN structure for the gradient estimation algorithm with the orthogonal multiple access is proposed, in which the proposed DNN effectively learns the encoding/decoding at the transceiver over wireless backhaul. By exploiting the experimental data measured through the USRP‐based MD radars, the authors validate the motion classification performance of the proposed federated learning strategy and DL aided gradient estimation over the wireless backhaul link.
Exploiting Performance Analysis of Redundant System (KM+1S)
Authors: Goyal Nupur , Ram Mangey 
Published: January 2022

The present investigation seeks the steady state availability, reliability and mean time to failure of the 1-out-of (k + 1): G redundant system. A system having k active units (kM) and one unit (1S) as a warm standby redundancy have considered. The effects of various parameters on reliability measures have been analyzed by deriving two models. Model I is designed as a reliability model and Model II for steady state availability. The assumptions have been made that the detected faults in the redundant system is covered imperfectly. The Markov process, supplementary variable technique, Laplace transformation are adopted to determine the transient behavior of the system. Presented results based on numerical data to demonstrate the practical utilization of the developed models. This study is very helpful for the engineers to design a highly reliable redundant system with high profit in the industry.
Making it happen: data practices and the power of diplomacy among Danish organ transplant coordinators
Authors: Jensen Anja M. B. 
Published: January 2022

AbstractDanish transplant coordinators handle all data and logistics involved with the removal and transfer of organs from the body of an organ donor into several recipients in other Scandinavian hospitals. This entails a wide range of data work, not only in relation to sudden organ donation cases, but also to documenting transplantations, providing feedback on donation outcomes, and facilitating the data needed by surgeons or other health professionals. This article investigates the data practices of organ transplant coordinators through the lens of diplomacy. Based on participant observation and interviews among Danish transplant coordinators, I focus on the cross-disciplinary relations and negotiations characterizing organ exchanges and show how datafication in itself is not enough to ensure smooth transplantation processes. Organ transplantation depends on the diplomatic social skills of the coordinator and the personal relationships between coordinators, surgeons and ICU staff. By bringing into focus the power of diplomacy, I conceptualize these structurally invisible efforts enabling organ donation and its associated data practices. Diplomacy enables us to recognize and understand the relational efforts and aspects of datafication, and the tremendous amount of work and social skill that go into producing and exchanging data in contemporary healthcare.
LithPulser: An open-source pulse generator with 1 ns time resolution based on the Red Pitaya STEMlab 125-10 featuring real-time conditional logic for experimental control
Authors: Reisenbauer S. , Behal P. , Wachter G. , Trupke M. 
Published: January 2022

Many experiments in the physical sciences require high temporal resolution on multiple control channels and can benefit from conditional logic control of the experimental sequence patterns. We present LithPulser, a field programmable gate array (FPGA) based open-source digital pulser solution with 1 ns time resolution on 14 digital output channels. The pulser is set up on the affordable Xilinx Zynq-7010 FPGA in the form of the Red Pitaya STEMlab board 125-10. It offers up to 125 MHz bandwidth and a sequence duration of up to 4.2 s and features 16 sequence play control, including a conditional logic module reactive to input events in real-time. LithPulser is designed for a trial until success experimental use case.
Manipulation of the high-order harmonic generation in monolayer hexagonal boron nitride by two-color laser field
Authors: Kong Xiao-Shuang , Liang Hao , Wu Xiao-Yuan , Geng Lei , Yu Wan-Dong , Peng Liang-You 
Published: January 2022

We theoretically investigate the high-order harmonic generation (HHG) of the monolayer hexagonal boron nitride by two-color laser pulses, based on the ab initio time-dependent density-functional theory. We find that the waveform of the two-color laser field can dramatically control the harmonic spectrum. The two-color laser field can enhance the harmonic radiation more efficiently than the monochromatic pulse laser with the same incident energy. We investigate the influence of incident laser pulse parameters on the harmonic radiation, such as the relative phase of the two-color field, the amplitude ratio between component electric fields, and the laser orientation. We show that the HHG spectrum is controlled by both the electric field and the vector potential. The electronic band structure and the laser-matter energy transfer play an important role in determining the laser polarization for optimal HHG in the hBN crystal. Our work supplies a scheme to manipulate HHGs in two-dimensional materials and provides a potential methodology for the generation of intense extreme-ultraviolet pulses.
The ultrafast nonradiative processes and photodissociation dynamics investigation of S1 state in propanal
Authors: Wang Yanmei , Wei Jie , Cao Ling , Zhang Bing , Zhang Song 
Published: January 2022

The ultrafast nonradiative dynamics in the S1 electronic excited state and the corresponding photodissociation dynamics in propanal molecules have been studied with time-resolved photoelectron imaging and time-of-flight mass spectrometry at an excitation wavelength of 320 nm. The population of the S1 state undergoes ultrafast internal conversion (IC) to the highly vibrationally hot S0 state in a timescale of &lt;100 fs and nonradiative deactivation by intersystem crossing (ISC) to triplet T1 state occurring with a time constant of about several hundreds of femtoseconds. The ISC process is then followed by the dissociation on the T1 surface because the excitation energy is higher than the dissociation barrier along the C–C(HO) bond length coordinate. The dissociation product of the CHO radical has an appearance time of about 540 fs, which agrees well with the measured ISC relaxation time constant of 430 fs. The CO molecule is proposed to form at about 170 fs after the excitation, supporting the dissociation mechanism via the molecular channel following the IC decay of the S1 state. The energy of the first excited electronic state of the C3H6O+ is obtained to be 12.25 eV.