bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining Service Quality Attributes at Different Levels of Operation in Higher Education Institutions: How Could the Service Quality Perceptions of Students Contribute to a Better Understanding of Improvement Directions?
Authors: Surman Vivien , Tóth Zsuzsanna Eszter , Danó Györgyi 
Published: December 2022

Abstract
The service quality literature focusing on higher education has been expanding rapidly parallel with the increasing marketization of the sector which poses new challenges against institutional improvement efforts and the applied management toolkit. The primary objective of our paper is to demonstrate the results of a surveying carried out in the Hungarian higher education system. The participating students evaluated the importance of quality attributes that were previously defined at the programme and the institution levels of operation and also rated the performance they had experienced along the same attributes. Both the quantitative and the qualitative results demonstrate that the student perceptions about the institutional image primarily stem from their service quality perceptions gained at the programme level defining the total student experience. Therefore, the institutional actions aiming service quality improvements should incorporate the programme level experiences of students both for enhancing total student satisfaction and institutional reputation.
Penambahan Kapur Sebagai Stabilisasi Tanah Ekspansif untuk Lapisan Tanah Dasar (Subgrade)
Authors: Andajani Nur , Risdianto Yogie 
Published: December 2022

Tanah ekspansif tergolong tanah plastisitas tinggi mempunyai ciri kembang susut tinggi, tidak baik bilamana langsung didirikan bangunan di atasnya. Pada beberapa proyek pembangunan jalan sering menimbulkan permasalahan geoteknik, sehingga sangat tidak nyaman bila dirasakan oleh pengguna jalan. Untuk itu perlu dilakukan perbaikan tanah atau stabilisasi. Stabilisasi tanah ekspansif dilakukan dengan menambahkan material yang lebih baik, sehingga mengurangi sifat plastisitas tanah tersebut. Stabilisasi menggunakan kapur, bertujuan memperkecil sifat plastisitas tanah, disamping untuk mengetahui batas minimum persentase kapur yang ditambahkan agar tanah ekspansif dapat digunakan sebagai lapisan tanah dasar (subgrade) untuk perkerasan jalan. Penelitian dilakukan di Laboratorium Mekanika Tanah Teknik Sipil Unesa. Kadar Kapur yang ditambahkan adalah 0%, 2.5%, 5%, 7.5% dan 10%. Pengumpulan data dilakukan melalui tes Atterberg Limit, Pemadatan Proctor Standart dan Calibration Bearing Ratio (CBR) test. Hasil yang didapat penambahan 10% kapur menurunkan Nilai batas cair sebesar 18.62%, dan menurunkYogiean Indeks Plastisitas Tanah sebesar 78.80%. Dengan penambahan 10% kapur nilai CBR untuk penetrasi 0,1 adalah 34,5 dan untuk penetrasi 0,2 adalah 31,54. Batasan minimum yang harus dipenuhi agar tanah dapat digunakan sebagai lapisan tanah dasar (subgrade) untuk perkerasan jalan yaitu harus ditambahkan 2.76% Kapur untuk CBR penetrasi 0,1 dan 3.23 % Kapur untuk CBR penetrasi 0,2.
Asociación entre religiosidad y síntomas ansiosos y depresivos en estudiantes universitarios
Authors: Ceballos Ospino Guillermo Augusto , Charris Karol Romero , Carrascal Gutiérrez Sindy Milena , Oviedo Acevedo Heidi Celina , Herazo Edwin , Campo Arias Adalberto 
Published: December 2022

Introducción: Existe información divergente acerca de la asociación entre religiosidad y síntomas emocionales. Un estudio con adolescentes colombianos observó falta de asociación estadísticamente significativa entre religiosidad y síntomas depresivos. No se conocen datos sobre este tópico en estudiantes universitarios. Objetivo: Estimar la asociación entre religiosidad y síntomas ansiosos y depresivos en universitarios de una institución colombiana. Método: Se realizó una investigación transversal correlacional. Los universitarios diligenciaron la escala breve de Zung para ansiedad, el Índice de Bienestar General para síntomas depresivos y la escala breve de Francis para religiosidad. Se calcularon correlaciones de Pearson (r) y se aceptaron diferencias significativas r superiores a 0,300 con probabilidad (p)<0,01. Resultados: Un total de 1.349 estudiantes de distintos programas académicos participó en la investigación. La media para la edad fue 20,6 años (DE=3,4) y el 50,7% eran hombres. Los coeficientes de alfa de Cronbach fueron 0,720, 0,763 y 0,966 para la escala breve de Zung para ansiedad, el Índice de Bienestar General para síntomas depresivos y la escala breve de Francis para religiosidad, respectivamente. Se encontró una asociación sin importancia estadística entre síntomas ansiosos (r=0,062; p>0,01) y síntomas depresivos (r=0,036; p>0,01) y la religiosidad. Conclusiones: El bienestar emocional de universitarios de una universidad colombiana cuantificado por síntomas ansiosos y depresivos es independiente de las puntuaciones en religiosidad. Este hallazgo corrobora la falta de asociación entre síntomas depresivos y religiosidad en adolescentes de Cartagena, Colombia. Se necesitan investigaciones en otras regiones del país.
Shakespeare’s Literary Architecture in King Lear
Authors: Mike Laura 
Published: December 2022

Book review:
Mudriczki, Judit. Shakespeare’s Art of Poesy in King Lear: An Emblematic Mirror of Governance on the Jacobean Stage. Budapest–Párizs: L’Harmattan, 2020. 126 pages. ISBN 978-2-343-20808-4. Pbk. 1990 HUF.
Geothermal potential of small sub-volcanic intrusions in a typical Icelandic caldera setting
Authors: Burchardt Steffi , Bazargan Mohsen , Bessi Gestsson Einar , Hieronymus Christoph , Ronchin Erika , Tuffen Hugh , Heap Michael J. , Davidson Jonathan , Kennedy Ben , Hobé Alex , Saubin Elodie 
Published: December 2022

Geothermal exploration targets large magmatic intrusions as heat sources because of their size, longevity, and amount of stored energy, but as shallow volcanic plumbing systems comprise numerous smaller intrusions, their geothermal potential warrants consideration. Here, we evaluate the geothermal impact of dykes and sills on caldera-infill rocks. We present geological data and geothermometry on intrusions in the eroded Breiðuvík caldera in Northeast Iceland, which serves as an analogue to the active, and geothermally exploited, Krafla volcano. These data inform 2D finite element models of dyke and sill intrusions that consider heat transfer in porous media. Our results indicate that small intrusions create considerable thermal anomalies in their immediate vicinity. These anomalies are larger-magnitude and longer-lasting for individual thick sills and dykes, but networks of smaller sills and dykes emplaced close in time and space can create more widespread thermal anomalies that may be viable economic targets for decades after their emplacement.
Preparation of biomass-based hydrogels and their efficient heavy metal removal from aqueous solution
Authors: Zhang Mingyue , Zhou Yaru , Wang Fangling , Chen Zeshao , Zhao Xu , Duan Weidong , Yin Guangting , Yang Xinling , Li Junfeng , Yin Quanyu , Zhao Mingqin 
Published: December 2022

In this work, a porous tobacco straw-based polyacrylic acid hydrogel STS-PAA with high adsorption performance was prepared by polymerizing pretreated waste tobacco straw (TS) with acrylic acid/potassium acrylate by UV radiation initiation. The adsorption performance of metal ions was investigated. The effects of different temperatures (25°C, 35°C, and 45°C), adsorption times (1–420 min), pH values (2.0–6.0) and initial concentrations (0.25–4.0 mmol L−1) of metal ions on the adsorption amount of heavy metal ions were investigated. The results showed that the hydrogel had a high removal rate of Pb2+, Cd2+ and Hg2+ in aqueous solution. The adsorption of Pb2+ was particularly effective. When C0 = 4.0 mmol L−1, pH = 6, the equilibrium adsorption amount of Pb2+, Cd2+ and Hg2+ reached 1.49 mmol g−1, 1.02 mmol L−1 and 0.94 mmol g−1, respectively. The chemical structure and morphology of the hydrogels were characterized by FT-IR, EDS, SEM and XPS. The Langmuir model fits well with the adsorption system. The kinetic data suggest the adsorption of Pb2+, Cd2+ and Hg2+ follow the pseudo-first-order model. This indicates that STS-PAA adsorption of three heavy metal ions is monolayer physical adsorption. Thermodynamic analysis shows that the adsorption of Pb2+, Cd2+ and Hg2+ by STS-PAA is an endothermic (ΔH&gt;0) entropy increase (ΔS&gt;0) non-spontaneous reaction.
Brain-gut-liver axis: Chronic psychological stress promotes liver injury and fibrosis via gut in rats
Authors: Xu Meng-Yang , Guo Can-Can , Li Meng-Ying , Lou Yu-Han , Chen Zhuo-Ran , Liu Bo-Wei , Lan Ling 
Published: December 2022

BackgroundThe effect of chronic psychological stress on hepatitis and liver fibrosis is concerned. However, its mechanism remains unclear. We investigated the effect and mechanism of chronic psychological stress in promoting liver injury and fibrosis through gut.MethodsSixty male SD rats were randomly assigned to 6 groups. Rat models of chronic psychological stress (4 weeks) and liver fibrosis (8 weeks) were established. The diversity of gut microbiota in intestinal feces, permeability of intestinal mucosa, pathologies of intestinal and liver tissues, collagen fibers, protein expressions of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa β (NF-κβ), tumor necrosis factor α (TNF-α) and interleukin 1 (IL-1) in liver tissue, liver function and coagulation function in blood and lipopolysaccharide (LPS) in portal vein blood were detected and analyzed.ResultsThe diversities and abundances of gut microbiota were significant differences in rats among each group. The pathological lesions of intestinal and liver tissues, decreased expression of occludin protein in intestinal mucosa, deposition of collagen fibers and increased protein expression of TLR4, MyD88, NF-κβ, TNF-α and IL-1 in liver tissue, increased LPS level in portal vein blood, and abnormalities of liver function and coagulation function, were observed in rats exposed to chronic psychological stress or liver fibrosis. There were significant differences with normal rats. When the dual intervention factors of chronic psychological stress and liver fibrosis were superimposed, the above indicators were further aggravated.ConclusionChronic psychological stress promotes liver injury and fibrosis, depending on changes in the diversity of gut microbiota and increased intestinal permeability caused by psychological stress, LPS that enters liver and acts on TLR4, and active LPS-TLR4 pathway depend on MyD88. It demonstrates the possibility of existence of brain-gut-liver axis.
In silico high-throughput screening system for AKT1 activators with therapeutic applications in sepsis acute lung injury
Authors: Wang Ziyi , Wang Xuesong , Guo Zhe , Liao Haiyan , Chai Yan , Wang Ziwen , Wang Zhong 
Published: December 2022

PurposeAKT1 is an important target in sepsis acute lung injury (SALI). The current study was aim to construct a high-throughput screening (HTS) system based on the ChemDiv database (https://www.chemdiv.com/complete-list/) and use the system to screen for AKT1 activation agents, which may provide clues for the research and development of new drugs to treat SALI.MethodsBased on the existing X-ray structure of AKT1 and known AKT activators, a large-scale virtual HTS was performed on the ChemDiv database of small molecules by the cascade docking method and demonstrated both accuracy and screening efficiency. Molecular docking and molecular dynamics simulations were used to assess the stability and binding characteristics of the identified small-molecule compounds. The protective effect of the new highly selective compound on SALI were verified both in vitro and in vivo experiments.ResultsThe small-molecule compound 7460-0250 was screened out as a specific activator of AKT1. Molecular validation experiments confirmed that compound 7460-0250 specifically promoted the phosphorylation of AKT1 and down-regulated the LPS-induced apoptosis of human umbilical vein endothelial cells (HUVECs) by activating the AKT-mTOR pathway. Up-regulated mTOR was detected to directly interact with Bax to reduce apoptosis. In vivo, compound 7460-0250 could improved survival rate and alleviated lung injury of sepsis mice induced by cecum ligation and puncture (CLP), parallel with the activation of the AKT-mTOR pathway.ConclusionSmall-molecule compound 7460-0250 was successfully screened and confirmed as a highly selective AKT1 activator, which is a critical target in the development of new therapeutics for SALI.
Pituitary adenomas and cerebrovascular disease: A review on pathophysiology, prevalence, and treatment
Authors: Osorio Robert C. , Oh Jun Y. , Choudhary Nikita , Lad Meeki , Savastano Luis , Aghi Manish K. 
Published: December 2022

Pituitary adenomas (PAs) have been shown to cause excess cardiovascular disease comorbidity and mortality. Cerebrovascular disease (CeVD) is a small subset of cardiovascular disease with high morbidity, and its risk in patients with pituitary adenomas has been sparingly explored. In this review, we examine what is known about the prevalence of cerebrovascular disease in patients with PAs, from its initial discovery in 1970 to present. An abundance of literature describes increased cerebrovascular mortality in patients with acromegaly, while research on other PA subtypes is less frequent but shows a similarly elevated CeVD mortality relative to healthy populations. We also review how cerebrovascular risk changes after PAs are treated, with PA treatment appearing to prevent further accumulation of cerebrovascular risk without reversing prior elevations. While acromegaly-associated CeVD appears to be caused by elevated growth hormone (GH) levels and Cushing disease’s elevated glucocorticoids similarly cause durable alterations in cerebrovascular structure and function, less is known about the mechanisms behind CeVD in other PA subpopulations. Proposed pathophysiologies include growth hormone deficiency inducing vessel wall damage or other hormone deficits causing increased atherosclerotic disease. Early diagnosis and treatment of PAs may be the key to minimizing lifetime CeVD risk elevations. More research is needed to better understand the mechanisms behind the increased CeVD seen in patients with PAs. Physicians caring for PA patients must remain vigilant for signs and symptoms of cerebrovascular disease in this patient population.
Identifying the molecular mechanisms of sepsis-associated acute kidney injury and predicting potential drugs
Authors: Guo Guangfeng , Wang Yunting , Kou Wanyu , Gan Hua 
Published: December 2022

Objective: To provide insights into the diagnosis and therapy of SA-AKI via ferroptosis genes.Methods: Based on three datasets (GSE57065, GSE30718, and GSE53771), we used weighted co-expression network analysis to identify the key regulators of SA-AKI, its potential biological functions, and constructed miRNA‒mRNA complex regulatory relationships. We also performed machine learning and in vitro cell experiments to identify ferroptosis genes that are significantly related to SA-AKI in the two datasets. The CIBERSORT algorithm evaluates the degree of infiltration of 22 types of immune cell. We compared the correlation between ferroptosis and immune cells by Pearson’s correlation analysis and verified the key genes related to the immune response to reveal potential diagnostic markers. Finally, we predicted the effects of drugs and the potential therapeutic targets for septic kidney injury by pRRophetic.Results: We found 264 coDEGs involving 1800 miRNA molecules that corresponded to 210 coDEGs. The miRNA‒mRNA ceRNA interaction network was constructed to obtain the top-10 hub nodes. We obtained the top-20 ferroptosis genes, 11 of which were in the intersection. We also identified a relationship between ferroptosis genes and the immune cells in the AKI dataset, which showed that neutrophils were activated and that regulatory T cells were surpassed. Finally, we identified EHT1864 and salubrinal as potential therapeutic agents.Conclusion: This study demonstrated the roles of miR-650 and miR-296-3p genes in SA-AKI. Furthermore, we identified OLFM4, CLU, RRM2, SLC2A3, CCL5, ADAMTS1, and EPHX2 as potential biomarkers. The irregular immune response mediated by neutrophils and Treg cells is involved in the development of AKI and shows a correlation with ferroptosis genes. EHT 1864 and salubrinal have potential as drug candidates in patients with septic acute kidney injury.
Population genetic analyses unveiled genetic stratification and differential natural selection signatures across the G-gene of viral hemorrhagic septicemia virus
Authors: Nigar Kiran , Kakakhel Sehrish , Khan Asifullah , Khan Hizbullah , Zaib Komal , Wen Shaoqing 
Published: December 2022

Introduction: Viral hemorrhagic septicemia virus (VHSV) is the most lethal pathogen in aquaculture, infecting more than 140 fish species in marine, estuarine, and freshwater environments. Viral hemorrhagic septicemia virus is an enveloped RNA virus that belongs to the family Rhabdoviridae and the genus Novirhabdovirus. The current study is designed to infer the worldwide Viral hemorrhagic septicemia virus isolates’ genetic diversity and evolutionary dynamics based on G-gene sequences.Methods: The complete G-gene sequences of viral hemorrhagic septicemia virus were retrieved from the public repositories with known timing and geography details. Pairwise statistical analysis was performed using Arlequin. The Bayesian model-based approach implemented in STRUCTURE software was used to investigate the population genetic structure, and the phylogenetic tree was constructed using MEGA X and IQ-TREE. The natural selection analysis was assessed using different statistical approaches, including IFEL, MEME, and SLAC.Results and Discussion: The global Viral hemorrhagic septicemia virus samples are stratified into five genetically distinct subpopulations. The STRUCTURE analysis unveiled spatial clustering of genotype Ia into two distinct clusters at K = 3. However, at K = 5, the genotype Ia samples, deposited from Denmark, showed temporal distribution into two groups. The analyses unveiled that the genotype Ia samples stratified into subpopulations possibly based on spatiotemporal distribution. Several viral hemorrhagic septicemia virus samples are characterized as genetically admixed or recombinant. In addition, differential or subpopulation cluster-specific natural selection signatures were identified across the G-gene codon sites among the viral hemorrhagic septicemia virus isolates. Evidence of low recombination events elucidates that genetic mutations and positive selection events have possibly driven the observed genetic stratification of viral hemorrhagic septicemia virus samples.
Structure and status of the Italian red coral forests: What can a large-scale study tell?
Authors: Toma Margherita , Bo Marzia , Giudice Daniele , Canese Simonepietro , Cau Alessandro , Andaloro Franco , Angiolillo Michela , Greco Silvestro , Bavestrello Giorgio 
Published: December 2022

The precious coral Corallium rubrum (Linnaeus, 1758) is a charismatic Mediterranean species. A recent large-scale investigation along the Italian coast highlighted its widespread occurrence at mesophotic and upper bathyal depths, especially on coralligenous and bathyal vertical hardgrounds. The lack of morphometric data limited the considerations on the structure and health status of the populations, fundamental to identify the most vulnerable sites and the correct management actions. For this reason, a ROV dataset, consisting of 624 dives carried out between 40 m and 1825 m in the Ligurian Sea, Tyrrhenian Sea, and Sicily Channel, was analysed to extrapolate quantitative data to describe the populations. Ten random frames were obtained from each of the 170 sites hosting red coral. Density, height, and entanglement were evaluated for about 15700 colonies counted in the frames. The densest populations were mainly found between 40 m and 80 m, with a clear latitudinal density decrease. The mesophotic populations were characterized by both scattered and densely aggregated colonies, while the bathyal ones were dominated by sparse colonies. This study identified 17 major coral areas based on the geographic proximity of the sites hosting red coral and their topographic and oceanographic affinity. The size-frequency distribution of the heights was skewed towards the smaller classes in almost all populations, with a modal class between 2 cm and 4 cm. This study depicted a stress situation of the populations throughout the entire study area, which could be correlated also to the long-term harvesting pressure carried out in the basins. Two additional sources of direct mortality were pointed out in this study. Entanglement to artisanal and recreational fishing gear interested about 18% of the recorded colonies, mainly at mesophotic depths. Almost all populations suffered from mechanical entanglement, with the highest percentages in the Ligurian Sea and Sicilian areas. This study also highlighted a massive occurrence of recent deep mortality events, mainly along the eastern and southern coast of Sardinia and in the Campanian Archipelago. Thirty sites with extensive patches of dead colonies still in place were reported from 70 m to around 200 m, but their formation remains unclear.
Preference-based versus randomized controlled trial in prostate cancer survivors: Comparison of recruitment, adherence, attrition, and clinical outcomes
Authors: Alibhai Shabbir M. H. , Papadopoulos Efthymios , Durbano Sara , Tomlinson George , Mina Daniel Santa , Ritvo Paul , Sabiston Catherine M. , Matthew Andrew G. , Chiarotto James , Sidani Souraya , Culos-Reed S. Nicole 
Published: December 2022

IntroductionPatients’ unwillingness to be randomized to a mode of exercise may partly explain their poor recruitment, adherence, and attrition in randomized controlled trials (RCTs) of exercise in oncology. It is unknown whether a preference-based trial can improve recruitment, adherence, retention, and clinical outcomes compared to a RCT of the same exercise interventions.ObjectiveWe assessed the effects of a 2-arm exercise preference trial on adherence and clinical outcomes compared to a similar 2-arm RCT in men with prostate cancer (PC).MethodsThis was a two-arm preference-based trial of group-based training (GROUP) or home-based training (HOME). PC survivors on androgen deprivation therapy (ADT) who declined randomization to the RCT but chose to participate in a preference trial were recruited in four Canadian centers. All study participants engaged in aerobic and resistance training, 4-5 days weekly for 6 months, aiming for 150 minutes/week of moderate-to-vigorous physical activity. The primary outcomes were changes from baseline to 6 months in fatigue and functional endurance. Secondary outcomes were quality of life, physical fitness, body composition, blood markers, and adherence. Linear mixed models were used to assess the effects of HOME versus GROUP on primary outcomes. In pooled preference and RCT data, the selection effect (i.e., difference between those who were and were not willing to be randomized) and treatment effect (i.e., difference between GROUP and HOME) were estimated using linear regression.Results and conclusionFifty-four participants (mean [SD] age, 70.2 [8.6] years) were enrolled (GROUP n=17; HOME n=37). Comparable effects on primary and secondary outcomes were observed following GROUP or HOME in the preference-based trial. Adherence was similar between preference and RCT participants. However, attrition was higher in the RCT (50.0% vs. 27.8%, p= 0.04). Compared to GROUP, HOME was more effective in ameliorating fatigue (mean difference: +5.2, 95%CI=1.3 to 9.3 p=0.01) in pooled preference and RCT data. A preference-based trial results in comparable observed effects on clinical outcomes and adherence and lower attrition compared with a RCT of the same exercise interventions in PC survivors on ADT. Given the appeals of preference-based trials to study participants, additional studies are warranted.Clinical trial registrationclinicaltrials.gov, identifier (NCT03335631).