bluuebunny/crossref_metadata_2025_split huggingface dataset:
The central role of peers facilitators in the empowerment of breast cancer patients: a qualitative study
Authors: Lognos Béatrice , Boulze-launay Isabelle , Élodie Million , Bourrel Gérard , Amouyal Michel , Gocko Xavier , Bernard Clary , Ninot Grégory , Oude Engberink Agnès 
Published: July 2022

Abstract
Background
In 2020, the number of new cancer cases was estimated at 20 490 862 worldwide up from 18.1 million in 2018 and 14.1 million in 2012. Since the 2000s, cancer treatments have significantly improved, allowing either a cure or control of the disease. Patients share their experience of the disease and use supportive care solutions through involvement in patient associations and online forums. All the associations were built on the principle of “peer support,” which is based on mutual aid between people who suffer or have suffered from the same somatic or psychological illness or had the same life experience.
This experiential knowledge can be explored to understand the role of peers and associations in the appropriation of their cancer.

Methods
A qualitative phenomenological study was undertaken through semi-structured interviews with 12 participants. Interviews were audio-recorded, transcribed verbatim, then analyzed by means of triangulation up to the point of theoretical saturation by a semio-pragmatic method.

Results
Four categories emerged: (1) “Transforms a painful experience into a positive one. It mobilizes the human values of sharing, love, and humility, which facilitates resilience”; (2) “The characteristics of the association, a non-medical place between people sharing a common destiny, resonates with patients’ needs and improves their well-being”; (3) “The association transforms the patients’ experiences by facilitating engagement that leads to a patient-expert (empowerment)”; and (4) “Understanding what is happening to them is soothing, reassuring, because patients’ concerns need to be heard and their care understood”.

Conclusions
This study highlights patient associations can serve as the mediator of NPI and facilate the empowerment of breast cancer patients.

Practice implications
Educating health professionals in initial and continuing education about non-pharmacological interventions will be a major issue. Teaching the patient-centred approach to health professionals is one of the priorities in initial and continuing medical education.
Factors influencing the elderly’s adoption of mHealth: an empirical study using extended UTAUT2 model
Authors: Palas Jahir Uddin , Sorwar Golam , Hoque Md Rakibul , Sivabalan Achchuthan 
Published: July 2022

AbstractBackgroundDespite the high usage of mobile phones in daily life in developing countries like Bangladesh, the adoption and usage of mHealth services have been significantly low among the elderly population. When searching previous studies, the researchers have found that no studies have empirically investigated whether the quality of life and service quality are significant for mHealth adoption by elderlies in Bangladesh. Hence,this study aimed to extend the Unified Theory of Acceptance and Use of Technology by adding service quality and the quality of life to empirically find the key factors that influence elderlies’ intention to adopt and use mHealth services in Bangladesh.MethodsA face-to-face structured questionnaire survey method was used to collect data from 493 elderlies (aged 60 years and above) in Bangladesh. The data were analyzed with the Structural Equations Modelling (SEM) and Fuzzy Set Qualitative Comparative Analysis (fsQCA).ResultsSEM results suggested that Social Influence, Hedonic Motivation, Price Value, Habit, and Service Quality had significant impact (p < 0.05) on the elderlies’ behavioral intention to adopt mHealth services. Service Quality, Quality of Life, and elderlies’ Habit were found significant in explaining the Use Behavior of mHealth services. Quality of Life did not show significant (p > 0.05) effect on Behavioral Intention, which is inconsistent with existing literature. In addition, fsQCA findings suggest how the intensity of the influencers may contribute to high versus low m-health behavioral outcomes.ConclusionsThe findings have significant implications for theory, practice and future research as explained in the paper. The originality of this study is the integration of quality of life and service quality into UTUAT2 to explain the users’ behavioural intention and use behaviour. Overall, the findings may contribute to shaping appropriate policies for designing and implementing mHealth services effectively for elderlies in developing countries.
Application of machine learning models based on decision trees in classifying the factors affecting mortality of COVID-19 patients in Hamadan, Iran
Authors: Moslehi Samad , Rabiei Niloofar , Soltanian Ali Reza , Mamani Mojgan 
Published: July 2022

Abstract
Background
Due to the high mortality of COVID-19 patients, the use of a high-precision classification model of patient’s mortality that is also interpretable, could help reduce mortality and take appropriate action urgently. In this study, the random forest method was used to select the effective features in COVID-19 mortality and the classification was performed using logistic model tree (LMT), classification and regression tree (CART), C4.5, and C5.0 tree based on important features.

Methods
In this retrospective study, the data of 2470 COVID-19 patients admitted to hospitals in Hamadan, west Iran, were used, of which 75.02% recovered and 24.98% died. To classify, at first among the 25 demographic, clinical, and laboratory findings, features with a relative importance more than 6% were selected by random forest. Then LMT, C4.5, C5.0, and CART trees were developed and the accuracy of classification performance was evaluated with recall, accuracy, and F1-score criteria for training, test, and total datasets. At last, the best tree was developed and the receiver operating characteristic curve and area under the curve (AUC) value were reported.

Results
The results of this study showed that among demographic and clinical features gender and age, and among laboratory findings blood urea nitrogen, partial thromboplastin time, serum glutamic-oxaloacetic transaminase, and erythrocyte sedimentation rate had more than 6% relative importance. Developing the trees using the above features revealed that the CART with the values of F1-score, Accuracy, and Recall, 0.8681, 0.7824, and 0.955, respectively, for the test dataset and 0.8667, 0.7834, and 0.9385, respectively, for the total dataset had the best performance. The AUC value obtained for the CART was 79.5%.

Conclusions
Finding a highly accurate and qualified model for interpreting the classification of a response that is considered clinically consequential is critical at all stages, including treatment and immediate decision making. In this study, the CART with its high accuracy for diagnosing and classifying mortality of COVID-19 patients as well as prioritizing important demographic, clinical, and laboratory findings in an interpretable format, risk factors for prognosis of COVID-19 patients mortality identify and enable immediate and appropriate decisions for health professionals and physicians.
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice
Authors: Yeh Chi-Hsiao , Shen Zhao-Qing , Wang Tai-Wen , Kao Cheng-Heng , Teng Yuan-Chi , Yeh Teng-Kuang , Lu Chung-Kuang , Tsai Ting-Fen 
Published: July 2022

AbstractBackgroundThe human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse lifespan and healthspan. Here, we evaluate the feasibility of using a Cisd2 activator as an effective way of delaying aging.MethodsHesperetin was identified as a promising Cisd2 activator by herb compound library screening. Hesperetin has no detectable toxicity based on in vitro and in vivo models. Naturally aged mice fed dietary hesperetin were used to investigate the effect of this Cisd2 activator on lifespan prolongation and the amelioration of age-related structural defects and functional decline. Tissue-specific Cisd2 knockout mice were used to study the Cisd2-dependent anti-aging effects of hesperetin. RNA sequencing was used to explore the biological effects of hesperetin on aging.ResultsThree discoveries are pinpointed. Firstly, hesperetin, a promising Cisd2 activator, when orally administered late in life, enhances Cisd2 expression and prolongs healthspan in old mice. Secondly, hesperetin functions mainly in a Cisd2-dependent manner to ameliorate age-related metabolic decline, body composition changes, glucose dysregulation, and organ senescence. Finally, a youthful transcriptome pattern is regained after hesperetin treatment during old age.ConclusionsOur findings indicate that a Cisd2 activator, hesperetin, represents a promising and broadly effective translational approach to slowing down aging and promoting longevity via the activation of Cisd2.
CircPDSS1 promotes the proliferation, invasion, migration, and EMT of breast cancer cell via regulating miR-320c/CKAP5 axis
Authors: Liu Xia , Song Jingyong , Kang Yu , Wang Yaojia , Chen Anyue 
Published: July 2022

Abstract
Background
Breast cancer (BC) poses serious threats to women’s health. A large number of reports have proved that circular RNAs (circRNAs) exert vital functions in human cancers, including BC.

Methods
The function of circPDSS1 in BC cells was tested by CCK-8, colony formation, TUNEL, transwell-invasion, wound healing, and IF assays. RNA pull down, luciferase reporter and RIP assays were employed to verify the relationship among circPDSS1, miR-320c and CKAP5.

Results
CircPDSS1 was upregulated in BC cells, and circPDSS1 knockdown repressed BC cell malignant behaviors. Further, circPDSS1 was found to bind to miR-320c in BC cells, and miR-320c overexpression suppressed malignant processes of BC cells. MiR-320c could also bind to CKAP5. Moreover, miR-320c inhibition increased the level of CKAP5, but circPDSS1 downregulation decreased the level of CKAP5. Finally, rescue experiments indicated that CKAP5 knockdown countervailed the promoting effect of miR-320c inhibition on the malignant behaviors of circPDSS1-depleted BC cells.

Conclusions
CircPDSS1 promotes proliferation, invasion, migration as well as EMT of BC cells by modulating miR-320c/CKAP5 axis. Our finding may be useful for researchers to find new potential therapeutic or diagnostic targets for BC.
Are you tripping comfortably? Investigating the relationship between harm reduction and the psychedelic experience
Authors: Palmer Madelene , Maynard Olivia M. 
Published: July 2022

Abstract
Background
Alongside a recent revival in the use of psychedelics in clinical settings, there have been increases in the prevalence of recreational use, with many using psychedelics to deal with difficult emotions or to improve well-being. While clinical research is conducted in carefully controlled settings, this is not necessarily the case for recreational use. In this mixed methods online survey study, we aimed to develop an understanding of frequently used psychedelic harm reduction practices in recreational settings and how their use relates to the psychedelic experience. We also aimed to characterise users’ first and most recent psychedelic trips to understand how harm reduction changes with experience.

Methods
Participants (n = 163) recounted their first and most recent psychedelic experience by providing details about the harm reduction practices they employed and completing the Challenging Experience Questionnaire (CEQ) and Emotional Breakthrough Inventory (EBI). We also asked open-ended questions for a more in-depth qualitative understanding of their views on psychedelic harm reduction.

Results
Using ANOVA, we observe greater use of harm reduction practices for participants’ most recent versus first psychedelic experience and that use of these practices is positively associated with EBI scores and negatively associated with CEQ scores (particularly for the first experience). Participants engaged in a wide range of harm reduction practices and we provide details of those which are most commonly used and those which are deemed most important by experienced users. Our qualitative analysis indicated that participants were largely positive about psychedelics and many recounted profound positive experiences. While specifics of the drug they were taking was important for aspects of harm reduction, participants largely focused on the importance of ensuring a good “set and setting” for enhancing positive effects.

Conclusions
Our research helps us understand how engagement in harm reduction may increase with experience. Our mixed methods data shed light on the perceived importance of different harm reduction practices and examine their association with the psychedelic experience itself. Together, our research has important implications for the development of psychedelic harm reduction advice and provides opportunities for future research to explore the importance of these different practices in more detail.
Unveiling of brain transcriptome of masked palm civet (Paguma larvata) with chronic infection of Toxoplasma gondii
Authors: Yuan Hao , Zhang Xiu-Xiang , Yang Zi-Peng , Wang Xiao-Hu , Mahmmod Yasser S. , Zhang Pian , Yan Zi-Jing , Wang Yan-Yun , Ren Zhao-Wen , Guo Qing-Yong , Yuan Zi-Guo 
Published: July 2022

Abstract
Background
The aim of this study was to gain an understanding of the transcriptomic changes that occur in a wild species when infected with Toxoplasma gondii. The masked palm civet, an artifically domesticated animal, was used as the model of a wild species. Transcriptome analysis was used to study alterations in gene expression in the domesticated masked palm civet after chronic infection with T. gondii.

Methods
Masked palm civets were infected with 105 T. gondii cysts and their brain tissue collected after 4 months of infection. RNA sequencing (RNA-Seq) was used to gain insight into the spectrum of genes that were differentially expressed due to infection. Quantitative reverse-transcription PCR (qRT-PCR) was also used to validate the level of expression of a set of differentially expressed genes (DEGs) obtained by sequencing.

Results
DEGs were screened from the sequencing results and analyzed. A total of 2808 DEGs were detected, of which 860 were upregulated and 1948 were downregulated. RNA-Seq results were confirmed by qRT-PCR. DEGs were mainly enriched in cellular process and metabolic process based on gene ontology enrichment analysis. Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that transcriptional changes in the brain of infected masked palm civets evolved over the course of infection and that DEGs were mainly enriched in the signal transduction, immune system processes, transport and catabolic pathways. Finally, 10 essential driving genes were identified from the immune signaling pathway.

Conclusions
This study revealed novel host genes which may provide target genes for the development of new therapeutics and detection methods for T. gondii infection in wild animals.

Graphical Abstract
Shoulder biomechanics of para-table tennis: a case study of a standing class para-athlete with severe leg impairment
Authors: Kong Pui Wah , Yam Jia Wen 
Published: July 2022

Abstract
Background
Both able-bodied and Class 7 para-table tennis players compete while standing, but do they use the same techniques to hit the ball? This case study examined the shoulder joint kinematics of a highly skilled para-table tennis player with severe leg impairment.

Methods
One international level Class 7 male para-table tennis player was compared with a control group of 9 male, competitive university team players. Participants performed 15 trials of forehand and 15 trials of backhand topspin drives. Shoulder abduction/adduction angles and joint range of motion (ROM) were measured using an inertial measurement system.

Results
The joint ROM of the para-player was comparable to the control group in the forehand [para-player 38°, controls 32 (15)°] and slightly larger in backhand [para-player 35°, controls 24 (16)°]. Waveform analysis revealed significant differences in the entire forehand drives (p < .001) and the preparation (p < .001) and follow-through phases (p = .014) of the backhand drives.

Conclusions
Coaches should not simply instruct para-table tennis players to replicate the characteristics of able-bodied players. Depending on the nature of the physical impairment, para-players should optimise their movement strategies for successful performance.
Acute effects of a 60-min time trial on power-related parameters in trained endurance runners
Authors: Cartón-Llorente Antonio , Roche-Seruendo Luis E. , Mainer-Pardos Elena , Nobari Hadi , Rubio-Peirotén Alberto , Jaén-Carrillo Diego , García-Pinillos Felipe 
Published: July 2022

Abstract
Background
The advent of power meters for running has raised the interest of athletes and coaches in new ways of assessing changes in running performance. The aim of this study is to determine the changes in power-related variables during and after a strenuous endurance running time trial.

Methods
Twenty-one healthy male endurance runners, with a personal record of 37.2 ± 1.2 min in a 10-km race, completed a 1-h run on a motorized treadmill trying to cover as much distance as they could. Before and after the time trial the athletes were asked to perform a 3-min run at 12 km h−1. Normalized mean power output, step frequency, form power and running effectiveness were calculated using the Stryd™ power meter. Heart rate (HR) and rating of perceived exertion (RPE) were monitored, and data averaged every 5 min.

Results
Despite high levels of exhaustion were reached during the time trial (HRpeak = 176.5 ± 9.8 bpm; RPE = 19.2 ± 0.8), the repeated measures ANOVA resulted in no significant differences (p ≥ 0.05), between each pair of periods for any of the power-related variables. The pairwise comparison (T test) between the non-fatigued and fatigued constant 3-min runs showed an increase in step frequency (p = 0.012) and a decrease in form power (p < 0.001) under fatigue conditions, with no meaningful changes in normalized mean power output and running effectiveness.

Conclusions
Trained athletes are able to maintain power output and running effectiveness during a high demanding extended run. However, they preferred to reduce the intensity of vertical impacts under fatigue conditions by increasing their step frequency.
Pseudoprogression in advanced non-small cell lung cancer treated with combination chemoimmunotherapy: a case report
Authors: Gonugunta Amrit S. , von Itzstein Mitchell S. , Gerber David E. 
Published: July 2022

Abstract
Background
Pseudoprogression, the initial apparent worsening of cancer prior to eventual improvement, is a documented feature of immune checkpoint inhibitor administration and presents a challenge to clinicians distinguishing true progression from pseudoprogression. This phenomenon does not typically occur with traditional cytotoxic chemotherapy. We present a case in which a patient treated with combination carboplatin-pemetrexed plus pembrolizumab experienced transient radiographic worsening of disease with subsequent regression.

Case presentation
A 65-year-old never-smoking white male with advanced sarcomatoid non-small cell lung cancer (NSCLC) harboring a MET exon 14 skipping mutation and with PD-L1 tumor proportion score of 80% was initiated on combination chemotherapy plus immune checkpoint inhibitor (ICI) therapy after progression on a MET inhibitor. After two cycles of carboplatin-pemetrexed plus pembrolizumab, repeat imaging suggested disease progression. Following discontinuation of the carboplatin-pemetrexed plus pembrolizumab regimen, the patient reported improved symptoms and energy levels, which were attributed to the waning of treatment-associated toxicities. On the day prior to initiation of the next planned line of therapy, repeat imaging was preformed to provide a baseline for treatment efficacy. Imaging revealed improvement compared to the prior imaging. Chemotherapy with carboplatin-pemetrexed plus pembrolizumab was resumed, with response ongoing 8 months later.

Conclusions
Pseudoprogression is a documented feature of ICI administration. Pseudoprogression is not typically observed in patients treated with traditional cytotoxic chemotherapy and has not yet been documented in patients treated with combination cytotoxic chemotherapy plus immunotherapy. At this time, there are no reliable means to predict or diagnose these rare events; therefore, more studies should be conducted to understand which patients are predisposed to developing this phenomenon and to increase clinical recognition.
Short measures of youth psychopathology: psychometric properties of the brief problem monitor (BPM) and the behavior and feelings survey (BFS) in a Norwegian clinical sample
Authors: Rognstad Kristian , Helland Siri Saugstad , Neumer Simon-Peter , Baardstu Silje , Kjøbli John 
Published: July 2022

Abstract
Background
Tracking clinical outcomes during therapy can be useful for improving both clinical practice and research. For repeated data collection, short, reliable, and valid measures of central aspects of psychopathology are necessary. The current paper investigates the psychometric properties of two short surveys for measuring central dimensions of psychopathology in youth.

Methods
We investigated the factor structure and validity of the Norwegian translations of the Behavior and Feelings Survey (BFS) and the Brief Problem Monitor (BPM). The BFS has previously shown a two-factor structure and indications of validity as a measure of internalizing and externalizing problems in youth. The BPM has support for a three-factor structure of internalizing, externalizing, and attention problems. In our sample of 503 patients (56% female, age 6 to 18) in a Norwegian outpatient clinic, we conducted confirmatory factor analyses to test the assumed measurement models and further considered the concurrent validity of the measures.

Results
Internal reliability of both measures were good. The results suggest that the assumed measurement models for both questionnaires only partly fit our data but that subscales of the BFS and BPM still indicate convergent validity. Scores on subscales (internalizing and externalizing problems) on both measures converged with relevant subscales as well as with relevant groups of diagnoses.

Conclusions
Alternative measurement models, and the usefulness and limitations of these short-form questionnaires for internalizing and externalizing problems, are discussed.