bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internet-based interventions for behavioral addictions: A systematic review
Authors: Boumparis Nikolaos , Haug Severin , Abend Stefanie , Billieux Joël , Riper Heleen , Schaub Michael P. 
Published: August 2022

Abstract

Background and aims
Behavioral addictions are a public health problem that causes harm to both individuals and society. Internet-based interventions offer potential benefits over face-to-face therapy for the treatment of behavioral addictions, including their accessibility, perceived anonymity, and low costs. We systematically reviewed the characteristics and effectiveness of these interventions.

Methods
A systematic literature search was conducted in: PubMed, PsycINFO, Embase, and the Cochrane Central Register of Controlled Trials. A standardized methodological quality assessment was performed on all identified studies via the Effective Public Health Practice Project (EPHPP) Quality Assessment Tool.

Results
Twenty-nine studies were assessed in this systematic review. Between them, considerable heterogeneity was noted in various study characteristics, including screening tools, inclusion criteria, and outcome measures. Attrition rates also ranged widely (9–89%), as did study quality, with three of the 29 studies rated strong, 12 moderate, and 14 weak methodologically. Twenty-two studies focused on gambling disorder, most revealing significant within-group effects for the assessed intervention on gambling-related symptoms and four of these studies identified significant between-group effects. Behavioral addictions studied in the remaining studies included gaming disorder, internet use disorder, hoarding disorder, and pornography use disorder, revealing generally-promising, albeit limited results.

Conclusions
Internet-based interventions seem promising at reducing gambling problems, but too few studies have been published, to date, for conclusions to be drawn for other behavioral addictions. Internet-based interventions targeting other behavioral addictions – like gaming disorder, internet use disorder, hoarding disorder, and pornography use disorder – remain under-examined, warranting considerable additional research to assess their effectiveness.
Comparing the effect of myofascial release and muscle energy technique on craniovertebral angle and headache in tension type headache patients
Authors: Sharma Ankita , Sharma Ankita , Rizvi Moattar , Kumari Sunita , Sharma Pooja 
Published: August 2022

INTRODUCTION: Tension headaches can be induced by forward head posture, and there is a wealth of evidence available for managing chronic headaches. The data supports the use of manual therapy approaches to manage tension type headaches. Because of the forward head posture, the suboccipital muscle region becomes short, resulting in an increase in lordosis and neck pain. Patients with an even more forward head posture have a smaller cranio-vertebral angle, which in turn causes tension type headache. OBJECTIVE: The aim of this study is to compare the effects of Myofascial release therapy(MFR) and Muscle energy technique(MET) with general neck exercises on the cranio-vertebral angle and headache in tension type headache patients. METHODS: In total, 75 subjects with tension type headache and suboccipital muscle tenderness were recruited and randomized blindly into three groups: the MFR group, the MET group, and the control group (25 subjects in each group). A pre-craniovertebral angle was taken by photographic method, and a pre-headache disability index questionnaire was filled in. The MFR group receives cranio-basal release in the suboccipital region with neck exercises, the MET group receives post–isometric relaxation in the suboccipital region with exercises, and the control group receives only exercises for 2 weeks. After two weeks, the postcranial angle and the headache questionnaire were taken and measured. RESULTS: Craniovertebral angle and headache index showed significant improvement in both the MET and MFR groups. There was no significant difference when MET and MFR groups were compared. When compared with the control group, both MET and MFR showed a significant increase in craniovertebral angle. There was significant improvement in the headache index following MET, MFR, or routine neck exercise. CONCLUSION: Compared to the control group, MFR shows better results than MET on craniovertebral angle and headache.
Sağlık Çalışanlarının Çocuk İstismarı ve İhmali Konusundaki Farkındalıkları: Sağlıklı Hayat Merkezleri Örneği
Authors: ÜSTÜNDAĞ Alev 
Published: August 2022

Amaç: Çocuk istismarı ve ihmali konusunda tüm çocukların risk altında olduğu düşünüldüğünde özellikle birinci basamakta görev yapan sağlık personelinin bu konudaki farkındalıkları oldukça önemlidir. Bu nedenle yapılan çalışmada çocuk istismarı ve ihmali olgularının belirlenmesinde önemli görevler üstlenen ve Sağlıklı Hayat Merkezlerinde görev yapan personelin konu hakkındaki farkındalıklarının belirlenmesi ve karşılaştırılması amaçlanmıştır.
Yöntem: Betimsel bir araştırma olarak, nicel araştırma tekniğinin kullanıldığı bir çalışmadır. Araştırmaya Sağlıklı Hayat Merkezlerinde görev yapan 75 sağlık personeli katılmıştır. Veri toplama araçları olarak Çocuk İstismarı ve İhmali Farkındalık Ölçeği ile kişisel bilgi formu kullanılmıştır. Verilerin analizinde t testi, ANOVA testi ve Tukey post hoc testleri kullanılmıştır.
Bulgular: Araştırma sonucunda; Sağlıklı Hayat Merkezlerinde görev yapan personelin çocuk istismarı ve ihmali farkındalık düzeylerinin orta üstü düzeyde olduğu; duygusal istismar farkındalık düzeyinin çok düşük olduğu; sosyal çalışmacıların farkındalık puanı en yüksek olan meslek grubu oldukları; daha önce eğitim alanlar ve almayanlar arasındaki farkın genel anlamda anlamlı olmadığı, yeni mezun olanların ve meslekte yeni olanların daha kıdemlilere oranla farkındalık düzeylerinin daha yüksek olduğu belirlenmiştir.
Sonuç: Sağlık personelinin lisans öğrenimleri sırasında ve sonrasında gerekli eğitimler verilerek bu konudaki bilgi düzeyleri artırılmalıdır.
ROS 2 Configuration for Delta Robot Arm Kinematic Motion and Stereo Camera Visualization
Authors: Saipullah Khairul Muzzammil , Mohd Saad Wira Hidayat , Chong Sook Hui , Idris Muhammad Idzdihar , Ahmad Radzi Syafeeza 
Published: August 2022

The Delta robot is one of the robot types that is used in agriculture and industrial application. However, before the complex physical development of the robot, a simulation needs to be developed to ensure the perfect functionality of the design. Therefore, this paper presented a development of simulation for a parallel delta robot using a Robot Operating System 2 (ROS 2) environment and stereo camera visualization. The contribution of this research is to present the development details and the proposed solution to solve issues encountered during the development. The development of script in the format of eXtensible Markup Language (XML), Unified Robot Description Format (URDF), and Simulation Description Format (SDF) are presented for describing a robot's physical structure, allowing a robotic system to be depicted in a tree structure, and defining the delta robot arm, which is made up of closed-loop kinematic chain linkage that will be simulated in Gazebo. For the results, several Gazebo plugin libraries are compared and tested for the wheels motion control, stereo camera visualization, and delta robot arm kinematic motion. From the experiment, the best method is inverse kinematic motion the method is selected and used in the simulation. The selected method resulted in an average percentage error of 3.92%, 3.72%, and 2.92%, respectively for each joint.
Alignment of Local Wisdom Values ​​with Islamic Law in the Tradition of the Peta Kapanca Ceremony
Authors: Yono Yono , Amrin Amrin , Imamah Ade Irma 
Published: August 2022

This research aimed to examine the alignment of local wisdom values ​​with Islamic law in the tradition of the Peta kapanca ceremony in the Ambalawi sub-District. This study used a descriptive qualitative type with a phenomenological and sociological approach. The data collection method used observation, interviews, documentation, and a literature study. While the data analysis technique is descriptive and qualitative by reducing data, presenting data, and drawing conclusions. The results showed that the Peta kapanca tradition at the wedding ceremony of the Bima tribal community in the Ambalawi sub-district contained local wisdom values ​​in the form of faith values, brotherhood values, mutual help values, and patient values. The values ​​of local wisdom in the Peta kapanca tradition align with Islamic law, namely, having values ​​that do not conflict with Islamic teachings. This made local wisdom in the Peta kapanca tradition and Islamic teachings valuable as instruments in developing Islamic da'wah teachings. In addition, socio-culturally as a bulwark against the modern era in the form of globalization and liberalization due to the influence of outside culture, which is starting to erode.

Keywords: Local culture, Islamic law, Peta kapanca, wedding
Sleep Disturbances and Disorders in Patients with Knee Osteoarthritis and Total Knee Arthroplasty
Authors: Bartosiak Kimberly , Schwabe Maria , Lucey Brendan , Lawrie Charles , Barrack Robert 
Published: August 2022

➤ There is increasing evidence that patient-reported outcomes following total knee arthroplasty (TKA) are associated with psychosocial factors and pain catastrophizing. Sleep disturbance, pain, and mental health have a complex interaction, which, if unrecognized, can be associated with impaired patient-reported outcomes and dissatisfaction following TKA.➤ The gold standard of objective sleep assessment is polysomnography, which is not feasible to use routinely for TKA patients. Wearable devices are a validated and less costly alternative.➤ Subjective sleep measures, such as the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, or Patient-Reported Outcomes Measurement Information System (PROMIS) computerized adaptive test sleep domains, are simple to administer and provide additional insight into sleep disturbance. Although objective and subjective measures do not correlate precisely, they can be informative together.➤ Sleep disturbances in the elderly population are common and multifactorial in etiology, stemming from the interplay of sleep disorders, medication side effects, and pain. Commonly prescribed medications following TKA as well as postoperative pain can exacerbate underlying sleep disturbances.➤ Obstructive sleep apnea (OSA) is prevalent in patients seeking TKA. In the setting of OSA, postoperative opioids can cause respiratory depression, resulting in consequences as severe as death. A standardized multimodal pain protocol including anti-inflammatories and gamma-aminobutyric acid (GABA) analogues may allow for decreased reliance on opioids for pain control.➤ Surgeons should reassure patients that postoperative sleep disturbance is common and transient, collaborate with the patient’s primary care doctor to address sleep disturbance, and avoid prescription of pharmaceutical sleep aids.
Meniscal Extrusion
Authors: Kaiser Joshua T. , Damodar Dhanur , Udine Matthew J. , Meeker Zachary D. , McCormick Johnathon R. , Wagner Kyle R. , Krych Aaron J. , Chahla Jorge A. , Cole Brian J. 
Published: August 2022

➢ Pathologic meniscal extrusion can compromise meniscal function, leading to increased contact forces in the tibiofemoral compartment and the acceleration of osteoarthritic changes.➢ Extrusion is typically defined as radial displacement of ≥3 mm outside the tibial border and is best diagnosed via magnetic resonance imaging, although ultrasonography has also demonstrated encouraging diagnostic utility.➢ Surgical management of meniscal extrusion is based on the underlying etiology, the patient’s symptom profile, the preexisting health of the articular surface, and the risk of future chondral injury and osteoarthritis.
Deep Learning Approach of Drilling Decision for Subhorizontal Drain Geosteering Based on APC-LSTM Model
Authors: Zhu Dandan , Dai Xinping , Liu Yi , Wang Fei , Luo Xiaoting , Chen Dong , Ye Zhihui 
Published: August 2022

SummarySteering drilling is used for exploring oil, natural gas, and other liquid and gaseous minerals. Steering drilling consists of high-efficiency drill bits, steering power drilling tools, and logging while drilling (LWD) and is used in petroleum drilling engineering. This paper mainly discusses subhorizontal drain geosteering, one of the methods of guided subhorizontal drilling. We use the currently popular deep learning method to conduct intelligent guided drilling. Geosteering is a sequential drilling decision process under uncertain stratum environment. However, the current geosteering drilling process relies heavily on manual work and has no use of temporal context. This paper aims to solve decision-making of geosteering in deep well (between 4500 and 6000 km) or ultradeep well (between 6000 and 9000 km). To this end, we make three contributions: (1) a wide-angle eye mechanism to obtain more geological information; (2) an asymmetric peephole convolutional long short-term memory (APC-LSTM) approach for geosteering drilling decision, whose input data were assembled with the wide-angle eye mechanism; and (3) use of the deep convolution generative adversarial networks (DCGAN) model to generate simulated logging data and conduct experiments in the simulation environment to verify our proposed method. APC-LSTM can capture the spatial-temporal correlation better between different strata for decision-making. Meanwhile, the APC-LSTM drilling decision model achieved better performance than other advanced methods in two drilling data sets. Tested in a simulative drilling environment, our proposed model achieves excellent application effect. Moreover, our method has been applied to the wells of oil field in practice.
The regulatory and transcriptional landscape associated with triterpenoid and lipid metabolisms by the bHLH-zip transcription factor SREBP in the medicinal fungus Ganoderma lingzhi
Authors: Liu Yong-Nan , Wu Feng-Yuan , Tian Ren-Yuan , Shi Yi-Xin , Xu Zi-Qi , Liu Ji-Ye , Huang Jia , Xue Fei-Fei , Liu Gao-Qiang 
Published: August 2022

Abstract
Ganoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete genus Ganoderma. However, transcription factors directly regulating the expression of GA biosynthesis genes remain poorly understood. Here, the genome of Ganoderma lingzhi was de novo sequenced. Using DAP-seq, we identified putative targets of the transcription factor SREBP, including the genes of triterpenoid synthesis and lipid metabolism. Interactions between SREBP and the targets were verified by EMSA. RNA-seq showed that SREBP targets, mevalonate kinase and 3-hydroxy-3-methylglutaryl CoA synthetase in mevalonate pathway, sterol isomerase and lanosterol 14-demethylase in ergosterol biosynthesis, were significantly upregulated in the SREBP overexpression strain. In addition, 3 targets involved in glycerophospholipid/glycerolipid metabolism were upregulated. Then, the contents of mevalonic acid, lanosterol, ergosterol and 13 different GAs as well as a variety of lipids were significantly increased in this strain. Furthermore, the effects of SREBP overexpression on triterpenoid and lipid metabolisms were recovered when OE::SREBP strain were treated with exogenous fatostatin, a specific inhibitor of SREBP. Taken together, our genome-wide study clarified the role of SREBP in triterpenoid and lipid metabolisms of G. lingzhi.
Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments
Authors: Neves Mariana , Klippert Antonina , Knöspel Fanny , Rudeck Juliane , Stolz Ailine , Ban Zsofia , Becker Markus , Diederich Kai , Grune Barbara , Kahnau Pia , Ohnesorge Nils , Pucher Johannes , Schönfelder Gilbert , Bert Bettina , Butzke Daniel 
Published: August 2022

Abstract
Background: European Union legislature requires replacement of animal experiments with alternative methods, whenever such methods are suitable to reach the intended scientific objective. However, searching for alternative methods in the scientific literature is a time-consuming task that requires careful screening of an enormously large number of experimental biomedical publications. The identification of potentially relevant methods, e.g. organ or cell culture models, or computer simulations, can be supported with text mining tools specifically built for this purpose. Such tools are trained (or fine tuned) on relevant data sets labeled by human experts. Methods: We developed the GoldHamster corpus, composed of 1,600 PubMed (Medline) abstracts, in which we manually identified the used experimental model according to a set of eight labels, namely: "in vivo", "organs", "primary cells", "immortal cell lines", "invertebrates", "humans", "in silico" and "other" (models). We recruited 13 annotators with expertise in the biomedical domain and assigned each article to two individuals. Three additional rounds of annotation aimed at improving the quality of the annotations with disagreements in the first round. Furthermore, we conducted various machine learning experiments based on supervised learning to evaluate the suitability of the corpus for our classification task. Results: We obtained more than 7,000 abstract-level annotations for the above labels. The inter-annotator agreement (kappa coefficient) varied among labels, and ranged from 0.63 (for "others") to 0.82 (for "invertebrates"), with an overall score of 0.74. The best-performing machine learning experiment used the BioBERT pre-trained model with fine-tuning to our corpus, which gained an overall f-score of 0.82. Conclusions: We obtained a high agreement for most of the labels, and our evaluation demonstrated, that our corpus is suitable for training reliable predictive models for automatic classification of biomedical literature according to the used experimental models. Our "Smart feature-based interactive" search tool (SMAFIRA) will employ this classifier for supporting the retrieval of alternative methods to animal experiments. The corpus and the source code will be made available.
A postnatal network of co-hepato/pancreatic stem/progenitors
in the biliary trees of pigs versus humans
Authors: Reid Lola , Zhang Wencheng , Lanzoni Giacomo , Wauthier Eliane , Simpson Sean , Allen Amanda , Suitt Carolyn , Dominguez-Bendala Juan , Cardinale Vincenzo , Alvaro Domenico , Overi Diletta , Gaudio Eugenio , Carpino Guido , Mathews Kyle , Adin Chrisotopher , Piedrahita Jorge , Sethupathy Praveen , He Zhiying 
Published: August 2022

Abstract
A network of co-hepato/pancreatic stem/progenitors exists postnatally in the intrahepatic, extrahepatic and intrapancreatic biliary trees of pigs and humans and found to support hepatic and pancreatic regeneration throughout life. The stem/progenitors have genetic signatures in liver/pancreas-related RNA-seq data based on Correlation, hierarchical clustering, KEGG and Short Time-series Expression Miner (STEM) analyses. Representative phenotypic traits are expression of pluripotency genes (SOX2, OCT4, KLF4), endodermal transcription factors (SOX9, SOX17, PDX1, NGN3), other stem cell traits (NCAM, EpCAM, BMI-1, CD44), and proliferation biomarkers (Ki67).
Stem/progenitor niches in vivo are in peribiliary glands (PBGs) throughout the intrahepatic and extrahepatic biliary tree, in duodenal submucosal glands (Brunner’s Glands), and in pancreatic duct glands (PDGs). The highest numbers of niches in humans are in PBGs in the hepato/pancreatic common duct, a duct missing in pigs; by contrast, the highest numbers in pigs are in Brunner’s Glands and in a subset of PDGS, those nearest to the duodenum. Elsewhere in PDGs in the porcine pancreas, and in all PDGs in the human pancreas, are found only committed unipotent and bipotent progenitors.
Multipotentiality of the stem/progenitors was indicated by their ability to yield hepatic versus pancreatic fates under distinct ex vivo conditions or in vivo when organoids of them were transplanted onto liver versus pancreas using patch grafting strategies. The findings establish pigs as logical hosts for translational/preclinical studies assessing grafts of organoids of the biliary tree’s co-hepato/pancreatic stem cells as cell therapies for diseases and dysfunctions in liver and pancreas both for humans and for veterinary animals.
Household disinfection practices by women living in Egypt during the 2020 COVID-19 lockdown and the association of information sources and suspected bleach toxicity
Authors: Farid Maha , Talaat Rania , Pacino Valerie , Tak Hyo Jung , ElRayes Wael 
Published: August 2022

Abstract
The spread of contradictory health information was a hallmark of the early COVID-19 pandemic. Because of a limited understanding of the disease, its mode of transmission, and its pathogenicity, the public turned to easily accessible and familiar sources of information. Some of these sources included wrong or incomplete information that could increase health risks and incidents of toxicity due to improper information about the usage of disinfectants. In this study, 452 adult women living in Egypt were surveyed through a self-administered online questionnaire in Arabic. The questionnaire collected data about their household cleaning and disinfection practices to prevent the spread of the SARS-CoV-2 virus and protect their families during the lockdown that started in Egypt in March 2020. The study found that 88.1 percent of participants reported increased use of disinfectants during the lockdown. Women who chose social media as their primary source of information to learn about disinfection practices reported an increased frequency of respiratory symptoms associated with bleach toxicity, followed by women who depended on relatives and friends as the primary source of information. This study showed that social media is a powerful tool that can act as a primary source for individuals seeking medical information. Restrictions and regulations may help limit the harms caused by the misinformation and disinformation spread by these popular modes of communication, particularly in times of uncertainty and upheaval.
Analysis of Length of Stay and Treatment Emergent Complications in Hospitalized Myasthenia Gravis Patients with Exacerbation
Authors: Ramsaroop Taylor , Gelinas Deborah , Kang Seung Ah , Govindarajan Raghav 
Published: August 2022

Abstract
INTRODUCTION/AIMS: Myasthenia Gravis (MG) is an autoimmune neuromuscular disease in which patients suffer from recurrent exacerbation. There are insufficient data measuring the effects of the resources employed before and during acute exacerbation on subsequent disease outcomes. This study aims to identify factors which lead to lengthened hospital stay. METHODS: This is a retrospective chart review of acute MG exacerbations requiring hospitalization. Exacerbations were identified using ICD-9/ICD-10 codes and considered the following variables: age and Myasthenia Gravis Foundation of America (MGFA) class at initial MG diagnosis, age and MGFA class at exacerbation, sex, thymectomy, cause of exacerbation, treatment regimen at time of exacerbation, inpatient treatment regimen, length of hospital stay (LOS), intubation, use of noninvasive ventilation, complications, and disposition.RESULTS: Seventy patients with 141 hospitalizations were identified. Crisis management characterized by intubation and plasmapheresis positively correlated with LOS (both p<.001). Almost 1/5 hospitalizations required intubation. Previous thymectomy negatively correlated with LOS (p <.05). In contrast, male sex correlated with longer LOS (p<.05). One-third of hospital stays were followed by discharge to a post-acute care facility, 7% home with home health, and 1 hospitalization resulted in death. DISCUSSION: Plasmapheresis, intubation, and male sex were associated with increased LOS in acute MG exacerbation. Intubation appears to be the strongest predictor of LOS. Those with previous thymectomy had shorter hospital stays. The role of thymectomy in the acute setting merits further analysis.