bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical value of hepatojugular reflux on congestive heart failure: A meta‐analysis
Authors: Iwata Hiroyoshi , Miwa Yoshikazu , Ikehara Yumi , Yodoshi Toshifumi , Ueda Shinichiro 
Published: August 2022

AbstractBackgroundHepatojugular reflux is a cardiac physical examination with a long history of use in heart failure diagnosis across many clinical settings. However, the development of new diagnostic methods has thrown the clinical role of hepatojugular reflux into question. Our meta‐analysis aimed to determine the diagnostic accuracy of hepatojugular reflux and assess its usefulness in diagnosing congestive heart failure among at‐risk patients.MethodsThis meta‐analysis of studies reporting diagnostic hepatojugular reflux values of patients at risk for congestive heart failure followed PRISMA guidelines. We searched MEDLINE, EMBASE, Web of Science, CENTRAL, and Google Scholar for eligible studies from inception through February 1, 2021. After QUADAS‐2 quality assessment, we conducted data synthesis using the random effects model and a hierarchical summary receiver operating characteristic model. As an additional analysis, we sorted the studies by clinical setting and performed synthesis again. We submitted our protocol to PROSPERO (International Prospective Register of Systematic Reviews; ID No. CRD42020215004).ResultsThe literature search provided 4121 studies for evaluation. Seven studies and their 5195 participants were deemed eligible for synthesis. Clinical diagnosis was the most frequent reference standard. Bivariate random‐effects analysis found hepatojugular reflux sensitivity of 0.12, 95% confidence interval (CI) [0.07–0.19], and specificity of 0.96, 95% CI [0.95–0.97]. The DOR was 29.7, 95% CI [18.4–45.3]. The additional analysis of the emergency settings provided a sensitivity of 0.14, 95% CI [0.12–0.17] and specificity of 0.95, 95% CI [0.93–0.96].ConclusionsOur meta‐analysis suggests that hepatojugular reflux has practical value for diagnosis of congestive heart failure with high specificity.
Higher RUNX1 expression levels are associated with worse overall and leukaemia‐free survival in myelodysplastic syndrome patients
Authors: Wang Yu‐Hung , Yao Chi‐Yuan , Lin Chien‐Chin , Chen Chi‐Ling , Hsu Chia‐Lang , Tsai Cheng‐Hong , Hou Hsin‐An , Chou Wen‐Chien , Tien Hwei‐Fang 
Published: August 2022

AbstractRUNX1 mutations are frequently detected in various myeloid neoplasms and implicate unfavourable clinical outcomes in patients with myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). On the other hand, high expression of RUNX1 is also correlated with poor prognosis in AML patients. However, the clinical relevancy of RUNX1 expression in MDS patients remains elusive. This study aimed to investigate the prognostic and biologic impacts of RUNX1 expression in MDS patients. We recruited 341 MDS patients who had sufficient bone marrow samples for next‐generation sequencing. Higher RUNX1 expression occurred more frequently in the patients with Revised International Prognostic Scoring System (IPSS‐R) higher‐risk MDS than the lower‐risk group. It was closely associated with poor‐risk cytogenetics and mutations in ASXL1, NPM1, RUNX1, SRSF2, STAG2, TET2 and TP53. Furthermore, patients with higher RUNX1 expression had significantly shorter leukaemia‐free survival (LFS) and overall survival (OS) than those with lower expression. Subgroups analysis revealed that higher‐RUNX1 group consistently had shorter LFS and OS than the lower‐RUNX1 group, no matter RUNX1 was mutated or not. The same findings were observed in IPSS‐R subgroups. In multivariable analysis, higher RUNX1 expression appeared as an independent adverse risk factor for survival. The prognostic significance of RUNX1 expression was validated in two external public cohorts, GSE 114922 and GSE15061. In summary, we present the characteristics and prognosis of MDS patients with various RUNX1 expressions and propose that RUNX1 expression complement RUNX1 mutation in MDS prognostication, wherein patients with wild RUNX1 but high expression may need more proactive treatment.
An assessment of perioperative outcomes for open, laparoscopic, and robot‐assisted pancreaticoduodenectomy in New York State
Authors: Wach Michael M. , Myneni Ajay A. , Miller Lorin , Boccardo Joseph , Ibrahim‐Zada Irada , Schwaitzberg Steven S. , Noyes Katia , Gajdos Csaba 
Published: August 2022

AbstractBackgroundMinimally invasive techniques for pancreaticoduodenectomy (PD) are increasing in practice, however, data remains limited regarding perioperative outcomes. Our study sought to compare patients undergoing open pancreaticoduodenectomy (OPD) with those undergoing laparoscopic (LPD) or robot‐assisted pancreaticoduodenectomy (RPD).MethodsPatients who underwent PD during 2016–2018 were identified from the New York State Planning and Research Cooperative System database.ResultsOf the 1954 patients identified, 1708 (87.4%) underwent OPD, 165 (8.4%) underwent LPD, and 81 (4.2%) underwent RPD. The majority of patients were White (63.8%), males (53.3%) with a mean age of 65.4 years. RPD patients had a lower median Charlson Comorbidity Index (2) than OPD (3) or LPD (3, p = 0.01) and had a lower 30‐day rate of complications (35.8% vs. 48.3% vs. 43.6% respectively, p = 0.05). After propensity‐score matching, however, there were no differences between the groups regarding overall complications, surgical site infections, anastomotic leaks, or mortality (p = NS for all). OPD demonstrated a longer length of stay (median 8 days) compared to LPD (7 days) or RPD (7 days, p < 0.01).ConclusionsPatients undergoing LPD and RPD have a shorter length of hospital stay compared to OPD and there was no difference in overall morbidity or mortality when matched to similar patients.
Comparative analysis of trilobal capillary‐channeled polymer fiber columns with superficially porous and monolithic phases toward reversed‐phase protein separations
Authors: Billotto Lacey S. , Marcus R. Kenneth 
Published: August 2022

A trilobal capillary‐channeled polymer fiber stationary phase is evaluated for its performance for intact protein separations under reversed‐phase high‐performance liquid chromatography conditions. The separation quality, operational characteristics, and protein dynamic loading capacity on the fiber phases are compared to commercially‐available superficially porous and monolithic columns. The trilobal or “y‐shaped” polypropylene fiber phase was employed to separate a synthetic mixture of five proteins (having diverse chemistries and molecular weights). The separation quality was evaluated based on the resolution, peak heights/recoveries, peak widths, and peak areas. The present work illustrates the unique ability to operate at higher linear velocities (47.5 mm/s) while maintaining lower back pressures (∼4 MPa), faster separation times (<8 min), and faster gradient rates using the fiber columns while yielding comparable chromatographic performance to the commercial columns. The separations employing the commercial stationary phases operate at lower linear velocities (∼3.0 mm/s), higher back pressures (∼9 MPa), require longer separation times (10 min), and require slightly higher compositions of organic mobile phase to effect protein elution. Likewise, based on breakthrough loading analysis of lysozyme and bovine serum albumin, the trilobal, polypropylene C‐CP fiber column stationary phases demonstrate 3–9X greater binding capacities on a bed volume basis versus the commercial columns.
Upper lip tie: A novel classification scale with improved inter‐rater reliability
Authors: So Raymond J. , Jenks Carolyn , Ryan Marisa A. , Tunkel David E. , McKenna Benoit Margo K. , Walsh Jonathan M. 
Published: August 2022

AbstractObjectivesUpper lip tie (ULT) is a clinical condition with restrictive attachment of the superior labial frenulum (SLF), which may inhibit flanging of the lips. Objective outcome studies are lacking in part due to unreliable classification systems that rely solely upon a single attachment parameter of the SLF. This study's objectives are to describe a novel 3‐point classification system for ULT and compare its inter‐rater reliability to the Kotlow and Stanford systems.MethodsFive raters used the Kotlow and Stanford systems, as well as our novel 3‐point scale to score images of the SLF from 20 newborns seen at our institution between September 1, 2017 and April 1, 2018. Newborn birth weight, gestational age, and demographic data were collected from the infant's medical record. Fleiss's kappa was used to calculate inter‐rater reliability for all classification systems.ResultsThe parameters for our novel 3‐point classification system for ULT were as follows: length from alveolar edge to frenulum gingival attachment, length of frenulum on stretch, and free‐lip to total‐lip length ratio. Our novel scale yielded the highest inter‐rater reliability of 0.41, compared to 0.24 and 0.25 under the Kotlow and Stanford systems.ConclusionWhile the Kotlow and Stanford systems are based upon a single anatomical parameter, our novel 3‐point classification scale uses three oral parameters that encompass anatomical points of attachment as well as the maximal length of the ULT on stretch. Our classification scheme is the first to incorporate a functional parameter of the SLF, and thereby more fully characterizes ULT.Level of Evidence: Level 4.
Epoxy‐Modified Pyrophyllite as a Multifunctional Chain Extender for Poly(latic acid)
Authors: Dai Zhixi , Li Juan , Huang Shaowen , Li Bo , Zou Xiaoyu , Wu Liangxi , He Min 
Published: August 2022

AbstractPyrophyllite (Prl), an aluminosilicate with a balanced mineral structure and extremely small particle size, appears to be an ideal filler but is rarely used in polymers. Herein, a method for the application of pyrophyllite in polymers is reported. A multifunctional filler is prepared by epoxy‐modified pyrophyllite and incorporated into poly(latic acid) (PLA) to enhance its processability and crystallization properties. Results show the effectiveness of epoxy‐modified Prl in composite film with a significant reduction in glass transition temperature, and noteworthy increment in crystallinity and spherulite growth rate. Water vapor barrier properties of PLA composite films increase over 30% with a range of Prl Loading. Furthermore, an enhancement of the tensile strength is increased by 30% and strain at break by 337.1% for PLA composite films compared to neat PLA. This work provides a new idea to prepare the functionalized pyrophyllite fillers and a theoretical basis to develop the application of pyrophyllite for polymers.
Understanding the origin and evolution of affinity as a multidisciplinary concept: A conceptual approach to consumer affinity
Authors: Serrano‐Arcos M. Mar , Sánchez‐Fernández Raquel , Pérez‐Mesa Juan Carlos , Riefler Petra 
Published: August 2022

AbstractThe use of the term affinity has been gradually spreading in several disciplines from multiple viewpoints. Among all these approaches, the concept of consumer affinity, which explains how consumers' positive dispositions toward a particular foreign country affect their purchase decisions of products from that origin, has recently emerged in the marketing discipline. In addition to the scarcity of theoretical and empirical studies on this concept, the marketing literature lacks a systematic review detailing the origin, evolution, and relevance of this notion and the remaining gaps to be investigated in this field. This study aims to examine the complex nature of consumer affinity and the difficulties that arise in its analysis at a conceptual and methodological level to examine its nature, characteristics, dimensionality, and relationship with other variables. To this end, through a systematic review using the PRISMA protocol, this study provides an integrated framework of the existing literature, analyzing the etymological origin and conceptual foundations of consumer affinity, its publication trajectory, and the main contributions to its study. Finally, this paper provides a roadmap for future research based on the convergences, inconsistencies, and knowledge gaps identified in the literature.
Comparison of Ultrasound and Electrical Stimulation Guidance for Onabotulinum Toxin‐A Injections: A Randomized Crossover Study
Authors: Lungu Codrin , Nmashie Alexandra , George Mary Catherine , Karp Barbara I. , Alter Katharine , Shin Susan , Tse Winona , Frucht Steven J. , Wu Tianxia , Koo Vivian , Considine Elaine , Norato Gina , Hallett Mark , Simpson David M. 
Published: August 2022

ABSTRACTBackgroundBotulinum neurotoxin (BoNT) injection is an established therapy for limb spasticity and focal limb dystonia. Comparative benefits of injection guidance procedures have not been rigorously studied.ObjectivesWe compared 2 targeting techniques for onabotulinumtoxin‐A (onabotA) injection for the treatment of focal hand dystonia and upper limb spasticity: electrophysiologic guidance using electrical stimulation (E‐stim) and ultrasound (US).MethodsThis was a 2‐center, randomized, crossover, assessor‐blinded trial. Participants with focal hand dystonia or upper limb spasticity, on stable onabotA therapy for at least 2 previous injection cycles, were randomly assigned to either E‐stim or US with crossover at 3 months. The primary outcome was improvement in dystonia or spasticity severity on a visual analog scale (VAS; 0–100) measured 1 month after each injection. The secondary outcome was participant discomfort assessed on a VAS. Repeated‐measures analysis of covariance was used with linear mixed‐model covariate selection.ResultsA total of 19 participants (13 men) completed the study, 10 with upper limb spasticity and 9 with dystonia. Benefit was equivalent between the 2 techniques (VAS least‐square mean [LSmean] 51.5 mm with US and 53.1 with E‐stim). E‐stim was perceived as more uncomfortable by participants (VAS LSmean 34.5 vs. 19.9 for E‐stim and US, respectively). Procedure duration was similar with the 2 procedures. There were no serious adverse events related to either approach.ConclusionsUS and E‐Stim localization guidance techniques provide equivalent efficacy in onabotA injections for spasticity and dystonia. US guidance injections are more comfortable for participants. Both techniques are effective guidance methods, with US potentially preferable based on participant comfort.
Valid inequalities and facets for multi‐module survivable network design problem
Authors: Luo Haochen , Kianfar Kiavash 
Published: August 2022

AbstractCapacitated survivable network design (SND), that is, designing a network that can survive edge failures with minimum flow‐routing plus capacity‐installation cost, is a fundamental problem in network science and its applications. In this article, we study a highly applicable form of the SND, referred to as the multi‐module SND (MM‐SND), in which transmission capacities on edges can be sum of integer multiples of differently sized capacity modules. We formulate MM‐SND as mixed integer programs, where existing structures of the network (p‐cycles) are used to protect edge failures. We derive valid inequalities for MM‐SND through polyhedral analysis and show that the valid inequalities previously developed in the literature for the single‐module SND are special cases of these inequalities. Furthermore, we show that these inequalities define facets for the convex hull of MM‐SND in many cases. Our computational results show that these inequalities are very effective in solving MM‐SND problem instances.
Collaboration between nurses and doctors in the decision‐making process when considering ending the life‐prolonging treatment of intensive care patients
Authors: Gjessing Kristine , Steindal Simen A. , Kvande Monica Evelyn 
Published: August 2022

AbstractAimsThe aim of the study was to explore intensive care nurses’ collaboration with doctors’ when considering ending the life‐prolonging treatment of patients in the intensive care unit.DesignA qualitative method with an explorative descriptive design was employed.MethodsData were collected through semi‐structured interviews with four intensive care nurses and four doctors working in three intensive care units at two university hospitals and one local hospital. The data were analysed using systematic text condensation. This study was reported according to the consolidated criteria for reporting qualitative research checklist.ResultsTwo categories were identified in the data analysis: listening to each other during the decision‐making process and continuity and having time to facilitate regular discussions of prognosis and treatment plans.
The delivery of Cultural Ecosystem Services in urban forests of different landscape features and land use contexts
Authors: Wang Yuan , Niemelä Jari , Kotze D. Johan 
Published: August 2022

Abstract

Urban greenspace provides citizens with important cultural ecosystem services (CES). Identifying landscape features and land use contexts that facilitate CES delivery is critical for guiding urban greenspace management. However, how landscape features and urban context interact with each other in influencing the CES of greenspaces remains unclear. Studies on the CES of patchy urban forests are needed as they are essential urban CES providers, but vulnerable under urban land use pressure.

To address these concerns, we compared the CES of 20 urban forest patches in Helsinki, Finland, with five different combinations of landscape features (i.e. size and connectivity) and land use contexts (i.e. surrounding construction density). CES were assessed through an on‐site survey on visitors' use, perceptions of CES experience and overall satisfaction, to capture the possible disparities among CES measurements.

In larger (>20 ha) forests, visitors were highly satisfied with CES, particularly appreciating the experience of physical health improvement and inspiration through longer and more intense physical uses. Visitors of urban forests in a low construction density context appreciated experiences of cultural heritage, psychological restoration and physical health improvement.

Urban forests deliver unique CES characterised by physical use and the benefit of restoration, aesthetics and contact with nature. We suggest that maintaining large urban forests is more effective in promoting CES in high‐density areas. In low‐density areas, maintaining small forests with open greenspace in the surroundings can also promote CES experiences. We identify management gaps caused by a mismatch between use intensity and CES experiences of urban forests, while both are important in determining people's overall satisfaction.

Read the free Plain Language Summary for this article on the Journal blog.
Navigating prognostic communication when children with poor‐prognosis cancer experience prolonged disease stability
Authors: Porter Amy S. , Chow Emma , Woods Cameka , Lemmon Monica E. , Baker Justin N. , Mack Jennifer W. , Kaye Erica C. 
Published: August 2022

AbstractBackgroundMost pediatric patients and families want clear prognostic information across the illness course. Yet when children with poor‐prognosis cancer experience prolonged disease stability, uncertainty can make communication particularly challenging. In this study, we aimed to (i) assess how frequently oncologists communicate about prognosis when high‐risk cancer does not progress, and (ii) describe prognostic communication patterns in the context of disease stability.Patients and methodsIn this prospective, longitudinal, mixed‐methods study, we audio‐recorded serial disease re‐evaluation conversations between children with poor‐prognosis cancer, their families, and their primary oncologists. For this secondary analysis, we conducted content analysis across serial conversations among 16 patient–parent–oncologist triads for whom the patient's disease remained stable over the 24‐month study period.ResultsPrognostic communication was absent in >50% of recorded conversations. Overall, it comprised only 4% of dialog time, nearly 90% of which was dialog about prognostic uncertainty; discussion of curability occurred infrequently. Three distinct patterns for prognostic communication emerged: (a) “Don't know” statements, avoiding or deferring prognostication; (b) “Worry” statements, preparing families for possible future disease progression; and (c) relief‐caveat statements, celebrating disease stability while balancing positivity with caution.ConclusionsOncologists seldom talked about prognosis with high‐risk patients during periods of disease stability; yet when they did, they used thoughtful and effective strategies to prepare families for possible future disease progression. Further research is needed to better understand if, how, and when patients and families with stable disease who are high risk for future disease progression prefer to receive information about prognosis.
The role of graphene nanoplatelets in the friction reducing process of polymer
Authors: Zhang Liyuan , Dong Conglin , Yuan Chengqing , Bai Xiuqin , Tian Ye 
Published: August 2022

AbstractControlling unabridged graphene‐lubricated layers and extending their last times can extend the service life of polymer moving components. The friction reduction behaviors of graphene nanoplatelets (GNP) on the tribology performances of high‐density polyethylene (HDPE) were studied based on friction experiments. The mechanical properties, coefficient of friction (COF), surface topography, tribo‐layers wear synthetically charactered to analyses the friction reducing processes. The results showed that the GNP presented a limited friction reduction to HDPE, and it could be controlled by the mass contents of GNP, load and speed. The proper content of graphene maintained the effective GNP tribo‐layers for a long time and led to a long duration of friction reduction. Decreasing load or speed weakened the wear processes, which was useful for maintaining the effective GNP tribo‐layers for a long time, and reduced the COF. The knowledge will provide experimental support for improving the self‐lubricating performance and abrasiveness of polymers.
Experimental and numerical investigation on compression after impact behavior of hygrothermal aged CFRP laminates
Authors: Huang Wenchao , Li Changyou , Xie Liyang , Jia Dawei , Chai Bao , Zhang Hongzhuang , Gao Ying 
Published: August 2022

AbstractIn the paper, a detailed experimental and numerical investigation of compression after impact (CAI) behavior of hygrothermal aged T300 985LV carbon/epoxy composites is presented. Rectangular fabric laminates are damaged by low‐velocity impact, and moisture absorption conditioning is carried out. The moisture absorption curves agree with Fick's law, with a moisture equilibrium rate of 0.84% at 1392 h. Then, CAI experiments are carried out on moisture saturated specimens at different temperatures. The effects of hygrothermal environments on CAI strength are obtained with an interpretation of corresponding mechanism. Furthermore, finite element analysis based on hygrothermal mechanics formulation and incremental Newton–Raphson mixed iteration equation is established. The numerical results are in good agreement with the experimental ones, with an accuracy of up to 92%, which demonstrates the effectiveness of the established numerical model. The results show that the CAI strength of 85 RH% hygroscopic saturated laminates is decreased by approximately 12% at 85°C and 17% at 128°C. Additionally, the allowable compression value of 3546 μɛ is obtained for T300 985LV composite laminates, which is useful for applications in civil aircraft design.