bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic routing maintains the unique fatty acid composition of phosphoinositides
Authors: Kim Yeun Ju , Sengupta Nivedita , Sohn Mira , Mandal Amrita , Pemberton Joshua G , Choi Uimook , Balla Tamas 
Published: June 2022

AbstractPhosphoinositide lipids (PPIn) are enriched in stearic‐ and arachidonic acids (38:4) but how this enrichment is established and maintained during phospholipase C (PLC) activation is unknown. Here we show that the metabolic fate of newly synthesized phosphatidic acid (PA), the lipid precursor of phosphatidylinositol (PI), is influenced by the fatty acyl‐CoA used with preferential routing of the arachidonoyl‐enriched species toward PI synthesis. Furthermore, during agonist stimulation the unsaturated forms of PI(4,5P)2 are replenished significantly faster than the more saturated ones, suggesting a favored recycling of the unsaturated forms of the PLC‐generated hydrolytic products. Cytidine diphosphate diacylglycerol synthase 2 (CDS2) but not CDS1 was found to contribute to increased PI resynthesis during PLC activation. Lastly, while the lipid transfer protein, Nir2 is found to contribute to rapid PPIn resynthesis during PLC activation, the faster re‐synthesis of the 38:4 species does not depend on Nir2. Therefore, the fatty acid side‐chain composition of the lipid precursors used for PI synthesis is an important determinant of their metabolic fates, which also contributes to the maintenance of the unique fatty acid profile of PPIn lipids.
PEMASARAN MADRASAH HUBUNGANNYA DENGAN JUMLAH PESERTA DIDIK BARU
Authors: Maulana Saepul , Ibrahim Tatang , Khoeruddin Heri 
Published: June 2022

This study aims to determine whether or not there is a positive and significant relationship between school marketing management and number of new student at Madrasah Tsanawiyah Ar-Rosidiah Cikuda Bandung. This paper using correlation reseach method, this method interpreted as measuring to whether or not relationship between school marketing management as X variable and number of new student as Y variable. As for the results of the study, it can be concluded that Ar-Rosidiyah's Student Perceptions about school marketing obtained an average value of 3.14. The number was included in the moderate qualification because it was in the 2.5-3.5 interval, the number of new students scored 3.07 with moderate qualification because it was in the interval 2.5-3.5. The results of the calculation of hypothesis testing show t count is 2.07 t table 1.71. Then the level of influence of the variables x and y is 40.5% and has a sufficient correlation. And this shows that there are other factors of 59.5% that influence the student's decision to enter Madrasah Tsanawiyah At-Rosidiyah.
IL6-inhibitors in treatment of SARS COVID19
Authors: Shcherbakov Serhii , Mazurenko Hanna , Yovenko Ihor 
Published: June 2022

The aim of this study was to evaluate the clinical efficacy and safety of a two-dose approach in the administration of tocilizumab in patients with SARS COVID19
Material and methods. The study was carried out on the basis of the Odrex Medical House in 2000-2021. The total sample included 4,112 patients hospitalized in a specialized department with coronavirus pneumonia. Of this sample, 150 patients were prescribed tocilizumab at a dose of 8 mg/kg of patient weight, including 36 (24.0 %) cases when tocilizumab was administered in a two-dose regimen. In the case of a two-dose regimen, the second dose was administered no earlier than 24 hours after the first one.
All patients were examined according to the current clinical protocols. The hemogram, the content of CRP, ferritin, interleukin-6 were assessed. All patients received dexamethasone intramuscularly at a dose of at least 6 mg per day.
Statistical processing was carried out by methods of analysis of variance using the software Statistica 13.0.
Results. After the use of tocilizumab, the patients had a decrease in body temperature and a decrease in the need for oxygen support. At the same time, the normalization of indicators of the activity of the systemic inflammatory response was observed.
Mortality after the use of tocilizumab was 29.3 %; in all cases, the deaths had an extremely severe course of coronavirus infection and a significant comorbid background. There were no manifestations of anaphylaxis and cases of secondary infection after the appointment of tocilizumab.
Conclusions. The use of tocilizumab could significantly improve the condition of patients with SARS COVID19. There were no signs of anaphylaxis and cases of secondary infection after the administration of tocilizumab. In the absence of a pronounced clinical effect within 24 hours after the first dose of tocilizumab in patients with severe SARS COVID19, it is advisable to re-administer the drug (two-dose regimen)
Assessment of the efficiency of biofuel use in the operation of marine diesel engines
Authors: Madey Volodymyr 
Published: June 2022

The object of research is the process of operation of marine diesel engines using biodiesel fuel. The subject of research is the process of experimental determination of the optimal concentration of biodiesel fuel in a mixture with fuel of petroleum origin. At the same time, a simultaneous maximum increase in environmental and minimum decrease in the economic parameters of the operation of a marine diesel engine should be ensured.
The studies were carried out on Hyundai Heavy Industries 5H17/28 marine diesel engines. Three such diesel engines were part of the power plant of a specialized marine ship with deadweight of 9600 tons. The study was aimed at determining the concentration of biofuel in a mixture with diesel fuel, which provides the best environmental performance of a diesel engine. The fuel supply circuit to the first diesel did not change and the diesel was operated on RMB30 fuel. Two other diesel engines were operated on a fuel mixture – RMB30 fuel and B99.9 FAME biofuel. The content of biofuel in the mixture varied in the range of 5–20 %. The main quantities measured during the experiment were the concentration of nitrogen oxides and the volumetric content of carbon monoxide in the exhaust gases, as well as the specific effective fuel consumption. By switching groups of consumers, the operation of diesel engines was carried out at the same load, the support of which was required during the experiment. The load on diesel engines during the experiments varied in the range of 55–85 % of the nominal value. The operation of diesel engines in each of the studied modes was carried out for at least 1.5–2 hours, during which the main parameters were measured and the obtained values were averaged.
It has been established that the use of biofuel increases the environmental friendliness of the marine diesel engine:
– by 7.6–26.61 % (depending on the diesel loading and the content of biofuel in the fuel mixture), the emission of nitrogen oxides with exhaust gases is reduced;
– by 3.8–23.6 % (depending on diesel loading and biofuel content in the fuel mixture) reduces the emission of carbon oxides with exhaust gases.
It has been also determined that when using biofuel, there is an increase in the specific effective fuel consumption by 0.5–8.65 %, which reduces the efficiency of a diesel engine.
The optimal composition of the fuel mixture containing biofuel is proposed to be determined experimentally for each diesel load, taking into account its environmental and economic indicators.
Non‐convulsive status epilepticus in the setting of cannabidiol adjunctive therapy
Authors: Tanwir Asra , Szabó C. Ákos 
Published: June 2022

AbstractAnti‐seizure medications (ASMs) can cause non‐convulsive status epilepticus (NCSE), but account for less than 5% of all NCSE cases. We present a 63‐year‐old, right‐handed male with a history of intractable focal epilepsy since age seven years old, whose bouts of NCSE were triggered by cannabidiol (CBD) adjunctive therapy. His most common seizure types included focal myoclonic or tonic seizures with vocalization, usually with awakening, which occurred on a monthly basis despite the combination of tiagabine, perampanel, levetiracetam, lacosamide and clonazepam. After CBD was initiated, he began to exhibit episodes of prolonged confusion, at times with myoclonic or tonic seizures. Increasing CBD doses led to more frequent and prolonged episodes. The confusional episodes occurred predominantly in the morning, with spontaneous resolution by the afternoon. During one of these episodes, he was hospitalized, and NCSE was confirmed by video‐EEG monitoring. CBD was withdrawn and the patient had no further episodes of NCSE. While CBD can cause NCSE, the medication interaction between CBD and tiagabine also needs to be considered.
Tokat İli (Türkiye) orman alanlarından izole edilen yerel entomopatojen fungusların patates böceği Leptinotarsa decemlineata (Say, 1824) (Coleoptera: Chrysomelidae)’ya etkisi
Authors: POLAT İlker , YANAR Yusuf , YANAR Dürdane 
Published: June 2022

Tokat İli (Türkiye) ve 11 ilçesinden 2014-2017 yılları arasında toplanan orman toprak örneklerinden izole edilen entomopatojenik fungusların, Kolorado patates böceği, Leptinotarsa decemlineata (Say, 1824) (Coleoptera: Chrysomelidae)'nın üçüncü dönem larva ve erginleri üzerindeki etkileri laboratuvar koşullarında değerlendirilmiştir. İlk olarak 33 izolatın L. decemlineata larvaları ve erginleri üzerindeki etkinliğini belirlemek için 1×108 konidi/ml’de tek doz etkinlik denemeleri yapılmıştır. Tek doz etkinlik denemelerinde en yüksek ölüm oranlarını veren dört izolat olan Beauveria bassiana (Balsamo-Crivelli) Vuillemin (Hypocreales: Cordycipitaceae)’yı içeren GOPT-498-4, GOPT-529-2, GOPT-552, GOPT-562 izolatları 1×103, 1×105, 1×107, 1×108, 1×109 konidi/ml’de doz-ölüm denemelerinde kullanılmıştır. En düşük LC50 ve LT50 değerleri sırasıyla 1.4×106 konidi/ml ve 10.6 gün ile GOPT-552 izolatı için kaydedilmiş olup, bunu GOPT-562 ve GOPT-529-2 izolatları takip etmiştir. Beauveria bassiana (GOPT-552, GOPT-562) izolatları L. decemlineata larva ve erginlerine karşı daha etkili olmuştur. Dolayısıyla GOPT-552 ve GOPT-562 izolatlarının Kolorado patates böceğinin biyolojik kontrolü için potansiyele sahip olduğu görülmüştür.
Variability of Spectral Estimates of Stress Drop Reconciled by Radiated Energy
Authors: Ji Chen , Archuleta Ralph J. , Wang Yongfei 
Published: June 2022

ABSTRACTA review of a collection of theoretical source spectral models revealed: (1) Despite the well-known variation in predicting static stress drop Δσs from the seismic moment and corner frequency, all models, especially the three conventional models, suggest that earthquakes radiate about half of the available strain energy into the surrounding medium. This similarity justifies a less model-dependent approach to estimate Δσs, though estimates for natural earthquakes rely on apparent seismic radiation efficiency (=2σa/Δσs; σa is apparent stress of an earthquake). (2) When one attempts to use Δσs and spectral models to make predictions, such as apparent stress σa, there is a model-dependent discrepancy between the σa inferred from theoretical energy partitioning and the σa predicted using spherical mean corner frequency. Their ratio cp varies significantly from 1.0 for the Brune (1970, 1971) model to 6.38 for the Madariaga (1976) model. If one uses spectral models to predict the ground motion, cp must be considered. (3) We infer that the constancy of the “stress parameter” (Δσ˜) found in engineering seismology (e.g., Boore, 1983; Atkinson and Beresnev, 1998) is similar to having constant apparent stress, σa (e.g., Ide and Beroza, 2001). The observation that Δσ˜ is generally larger than the average static stress drop Δσs for global M &gt;5.5 shallow crustal earthquakes in active tectonic regions implies that these earthquakes radiate, on average, more seismic energy than predicted from the conventional dynamic crack models.
PENERAPAN PENDIDIKAN KARAKTER PADA MASA PANDEMI COVID-19 VARIAN OMICRON
Authors: Anjarsari Retno 
Published: June 2022

ABSTRACT
Character education during pandemics is a challenge for teachers as teachers. The case of the soaring omicron makes a teacher limited in providing character education to students. The spread of omicron cases in Indonesia soared due to the non-compliance of indonesian people to existing health protocols. Character education there are various kinds that can be taught to students. This study uses qualitative research by looking at the application of character education during the omicron period in Indonesia. The study focused on grade 2 at MIN 7 Blitar. By making observations in the class and interviewing the classroom teacher or classroom guardian in the 2nd grade. With this research can be taken the application of character education when this omicron case can run smoothly or there are obstacles that must be resolved.

Keywords: Character Education, Omicron Case, Student, Teacher

ABSTRAK
Pendidikan karakter pada masa pandemi merupakan tantangan tersendiri bagi guru selaku pengajar. Kasus omicron yang tengah melonjak membuat terbatasnya seorang guru dalam memberikan pendidikan karakter pada peserta didik. Penyebaran kasus omicron di Indonesia melonjak karena ketidak patuhan masyarakat Indonesia terhadap protokol kesehatan yang sudah ada. Pendidikan karakter ada berbagai macam yang bisa diajarkan kepada peserta didik. Studi ini menggunakan penelitian kualitatif dengan melihat penerapan pendidikan karakter pada masa omicron di Indonesia. Penelitian ini berfokus pada kelas 2 di MIN 7 Blitar. Dengan melakukan observasi pada kelas tersebut dan wawancara kepada guru kelas atau wali kelas pada kelas 2 tersebut. Dengan penelitian ini dapat diambil penerapan pendidikan karakter ketika kasus omicron ini dapat berjalan dengan lancar atau terdapat kendala yang harus diselesaikan.

Kata Kunci : Pendidikan Karakter, Kasus Omicron, Peserta didik, Guru
Preferencia y aceptabilidad sobre diferentes diseños de aparatos ortodónticos fijos en adolescentes peruanos
Authors: Camarena Fonseca Alexandra , Adriazola Pando Manuel 
Published: June 2022

Objetivo: Evaluar la preferencia y aceptabilidad sobre seis diferentes diseños de aparatos ortodónticos fijos en adolescentes peruanos de dos colegios de Lima. Material y métodos: Se realizó un estudio descriptivo y transversal en un total de 140 adolescentes con edades entre 10 y 16 años, que completaron una ficha de registro en donde se evaluó la preferencia, aceptabilidad, orden de preferencia y aceptabilidad al uso sobre seis diferentes diseños de aparatos fijos visualizados en un álbum de fotografías. Resultados: Los datos fueron analizados con el paquete estadístico SPSS versión 24.0. Se utilizó un nivel de significancia de 5% con un intervalo de confianza de 95%. Debido a la naturaleza de las variables, se utilizó la prueba de Chi cuadrado. Los adolescentes prefirieron los brackets metálicos con módulos elásticos de colores y arco de acero (24,3%, n=34); y la aceptabilidad fue de 92,1%. Para el orden de preferencia, se encontró la siguiente jerarquía de primer a sexto lugar: brackets metálicos con módulos elásticos de colores y arco de acero > brackets de zafiro con módulos elásticos transparentes y arco estético > brackets metálicos con módulos elásticos transparentes y arco de acero > brackets de zafiro con módulos elásticos transparentes y arco de acero > brackets de zafiro con módulos elásticos de colores y arco de acero > brackets metálicos autoligantes y arco de acero/brackets de zafiro con módulos elásticos de colores y arco de acero. Se encontró una asociación estadísticamente significativa para algunas preguntas sobre la aceptabilidad al uso en relación al grupo de edad, sexo e institución educativa. Conclusiones: Los adolescentes prefirieron los brackets metálicos con módulos elásticos de colores y arco de acero. Los brackets metálicos autoligantes con arco de acero y los brackets de zafiro con módulos elásticos de colores y arco de acero, presentaron menor porcentaje de preferencia.
Imperfect maintenance strategy of a three-stage failure process and a two-level inspection for train bogie system
Authors: He Deqiang , Zhou Nianwen , Liu Chenyu , Jin Zhenzhen , Chen Yanjun , Miao Jian 
Published: June 2022

Abstract
With the gradual expansion of the scale of urban rail transit, its safety and cost issues have aroused widespread concern. Aiming at the common phenomena of "over-maintenance" or "under-maintenance" in urban rail trains, the imperfect preventive maintenance model with a two-level inspection strategy based on a three-stage failure process for train bogie system is proposed. Firstly, three parameters of Weibull distribution of components are obtained by analyzing historical fault data. According to the reliability curve and failure rate obtained by Weibull three parameters, the single components are divided into three stages: normal driving stage, initial deterioration stage and severe deterioration stage, and the three stages are identified by a two-level inspection. Among them, the normal driving stage and the severe deterioration stage are identified by the low-level inspection, and at the same time, it is possible to identify the initial deterioration stage, while all stages are identified accurately by the high-level inspection. Secondly, maintenance economy and train availability are taken as the optimization condition of the imperfect maintenance strategy, and the obtained optimal imperfect maintenance interval is taken as the high-level inspection time in the two-level inspection. Then an inspection threshold is proposed to determine the functional relationship between the high-level inspection and the low-level inspection. With the minimum expected cost as the goal, the expected cost of single components is calculated through different low-level inspection time, inspection threshold and preventive repair threshold. Finally, taking certain city urban rail train bogie system as an example, it is found that the minimum expected cost of axle box subassembly is CNY 43.28 a day, the maintenance period is 428 days. The minimum expected cost of gear box subassembly is CNY 27.26 a day, and the maintenance period is 651 days. Compared with the similar models, the maintenance period is prolonged and the expected cost is reduced, which verifies the effectiveness and superiority of the model and provides a theoretical basis for scientific maintenance.
Impacts of an Undergraduate Research Assistant Program: The First Decade
Authors: Smith Sharon , Nguyen Adrienne , Chenard Danielle , Burnham Kristin , Albert Arlene 
Published: June 2022

Abstract
PurposeThere is a declining number of physician-scientists. Little is published about the potential for undergraduate student experiences to contribute to the pipeline of future researchers. The purpose of this study was to describe a unique undergraduate research program and report the outcomes of the first 10 years. MethodThe Undergraduate Research Assistant Program (URAP) was described including course content, research experiences, and student composition. Outcomes of URAP student contributions to the literature and research presentations was reported. URAP students were also surveyed to assess their perspectives on the impact of the URAP program on career choices after graduation.ResultsURAP began as an independent study course and grew into for-credit undergraduate college courses. There a total of 212 students have taken at least one semester and 88 responded to the survey. All students who attended URAP have graduated, and 77% (n=68) reported the URAP program prepared them to reach their career goals. Most graduates pursued health care careers including medical school (55%), Master’s programs in health care (29%), or PhD in health care (5%). URAP students participated in research involving 11 different pediatric subspecialties. Many attained co-authorship of abstracts and publications, 53 first-authored an abstract presentation and 7 manuscripts.ConclusionsURAP significantly impacted undergraduate students who overwhelmingly entered health care fields. While difficult to assess if these early experiences will influence participation as future physician –scientist, these students made meaningful research contributions while enrolled in these courses.
Construction of direct Z-scheme g-C3N4/BiYWO6 heterojunction photocatalyst with enhanced visible light activity towards the degradation of methylene blue
Authors: Bavani Thirungnanam , Madhavan Jagannathan , Preeyanghaa Mani , Neppolian Bernaurdshaw , Murugesan Sepperumal 
Published: June 2022

Abstract
Construction of the Z-scheme heterojunction photocatalyst achieved highly improved photocatalytic ability by its high redox ability of the photoinduced e−-h+ pairs. In the study, Z-scheme g-C3N4/BiYWO6 heterojunction photocatalyst is prepared by the single step hydrothermal method. Further, its photocatalytic ability was assessed by degrading methylene blue under visible light exposure. Particularly, the optimized 30 wt. % of g-C3N4 in the g-C3N4/BiYWO6 composite exposes almost complete degradation after 90 min, that is ~ 3.0 times greater than the bare BiYWO6 and g-C3N4 with the rate constant value 0.032 min− 1. Experimentally, the radical trapping studies indicates O2.− and .OH radicals are playing vital role in the photocatalytic degradation process. Also, Z-scheme g-C3N4/BiYWO6 heterojunction photocatalyst exhibits excellent photoelectrochemical property and it is stable after three cycles, which indicates its good reusability nature. These enhancements are due to the newly formed heterostructure that facilitates the migration and separation efficiency of the photoproduced e−-h+ pairs. Hence, the synthesized Z-scheme g-C3N4/BiYWO6 heterostructure could be an excellent material for wastewater remediation works.
The optimal FET strategy for the recurrent implantation failure patient: thawing Day 3 embryos and culturing to Day 5 blastocysts
Authors: Li Xiang , Zeng Youman , He Juan , Luo Bowen , Lu Xiongcai , Zhu Lingling , Yang Zengyu , Cai Fuman , Chen Sheng-ao , Luo Yudi 
Published: June 2022

Abstract
This study aimed to investigate the optimal frozen embryo transfer (FET) strategy in recurrent implantation failure (RIF) patients with three consecutive failed cleavage embryo implantations. A retrospective analysis of FET cycles performed in our IVF center from January 2018 to August 2020. The FET cycles were classified into three groups according to their FET strategies: thawed day 3 embryo transfer (D3 FET group) (n = 52), thawed blastocyst transfer (D5 FET group) (n = 166), and extended culturing of frozen-thawed day 3 embryos to day 5 blastocysts transfer (D3-5 FET group) (n = 58). The biochemical, clinical pregnancies, implantation, abortion, multiple pregnancy, and live birth were analyzed and compared among the three groups. A total of 43.8% of vitrified-thawed cleavage embryos developed into blastocysts in the D3-5 FET group. Although no statistically significant differences were observed in the number of transferred embryos and grade A embryos among the three groups, the pregnancy outcomes were significantly better in the D3-5 FET group, with higher biochemical, clinical pregnancy, implantation, and live-birth rates (all P < 0.05) in comparison with the D3 FET group. Interestingly, when compared with the D5 FET group, the D3-5 FET group showed a significantly higher implantation rate, although no difference was found in the clinical pregnancy rate and live birth outcomes. Our results suggest that D3-5 FET would be the optimal FET strategy for RIF patients with three repeated consecutive implantation failures by achieving better pregnancy outcomes than the direct D3 FET strategy.