bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of aromatization on the perception of work environment and job satisfaction
Authors: Čarnogurský Karol , Madzík Peter , Diacikova Anna , Bercik Jakub 
Published: September 2022

PurposeThe aim of this paper is to examine how indoor aromatization affects the expressed and unexpressed satisfaction with the work environment in the production hall of an industrial company.Design/methodology/approachThe aroma was flavored by an aromatization unit, the expressed satisfaction was measured on a scale and biometrics of facial recognition (FaceReader) was used to measure unexpressed satisfaction, enabling the recording of eight emotions and two basic emotions.FindingsResearch has shown the effect of aroma on two emotions – neutral and angry – which partially confirmed the sense of flavoring production facilities. Previous research has shown that positive feelings caused by a pleasant smell influence customers' purchasing decisions. As the use of aroma affects the mental state of the individual, it could be also applied for non-marketing purposes.Originality/valueTo date, there has been no research that systematically addresses the impact of aromatization on the perception of the work environment in a manufacturing company. The presented study is unique in its design and focus and provides basic information about the impact of aroma on individuals. The findings of this study can help to examine further aspects that indirectly affect performance.
A general hypothesis of forest invasions by woody plants based on whole‐plant carbon economics
Authors: Fridley Jason D. , Bellingham Peter J. , Closset‐Kopp Déborah , Daehler Curtis C. , Dechoum Michele S. , Martin Patrick H. , Murphy Helen T. , Rojas‐Sandoval Julissa , Tng David 
Published: September 2022

AbstractAlthough closed‐canopy forests are characterized by low‐light availability and slow population dynamics, many are under threat from non‐native, invasive woody species that combine high colonization ability and fast growth potential with high low‐light survival. This ‘superinvader’ phenotype contravenes expected trade‐offs predicted by successional niche theory, posing a challenge to both invasion and forest succession theory.We propose a parsimonious conceptual model based on the whole‐plant light compensation point (WPLCP) that, across a variety of plant strategies and growth forms, can explain greater competitive abilities of forest invaders in the context of both high‐light growth rate and shade tolerance. The model requires only that non‐native species experience relatively fewer carbon costs than native species, enabling resource‐acquisitive species to establish in low‐light conditions.We review evidence for lower carbon costs in invasive species resulting from (1) enemy release, (2) recent environmental changes that favour less stress‐tolerant phenotypes and (3) phylogenetically constrained native floras. We also discuss implications of invader shade tolerance in the context of other life‐history strategies that, combined with canopy disturbances, facilitate their rapid numerical dominance.Synthesis. An invasion framework driven by carbon dynamics suggests renewed focus on whole‐plant carbon costs, including below‐ground respiration and tissue turnover, which are rarely measured in functional studies of forest invaders.
Education for metaphysical animals
Authors: Bakhurst David 
Published: September 2022

Abstract
This essay explores the legacy of the four philosophers now often referred to as ‘The Wartime Quartet’: G.E.M. Anscombe, Iris Murdoch, Philippa Foot and Mary Midgley. The life and work of the four, who studied together in Oxford during the Second World War, is the subject of two recently published books, The Women Are Up to Something, by Benjamin Lipscomb, and Metaphysical Animals, by Clare Mac Cumhaill and Rachael Wiseman. The two books show us how Anscombe, Murdoch, Foot and Midgley became friends united in their hostility to the logical-positivist orthodoxy of the day and its deleterious influence on Oxford moral philosophy. And we see how their friendship had a formative influence on their subsequent—highly distinguished—careers, so that it is possible to discern, if not exactly a school of thought, then various common themes, ideas and concerns, which are expressed and developed in contrasting ways. While Lipscomb represents the work of the Quartet as of largely historical significance, my paper defends what I take to be Mac Cumhaill and Wiseman's position that their legacy is very much a living one, containing insights that are not just of enduring relevance, but can transform how we see ourselves and how we do philosophy. For Mac Cumhaill and Wiseman, the key idea shared by the members of the Quartet is to place the concept of life at the centre of philosophical attention. This commitment has at least four dimensions: (i) an interest in the ordinary; (ii) a focus on virtue, goodness and human flourishing; (iii) an affirmation of our animal nature; (iv) recognition of the normative landscape that structures our lives. I try to bring out the philosophical significance of these themes in a way relevant to the philosophical elucidation of education.
UN/DOING FUTURE, UNSETTLING TEMPORALIZATION
Authors: Chakkalakal Silvy , Ren Julie 
Published: September 2022

AbstractThe concept of the future, its prognostications and its applications increasingly shapes present social worlds. From government policy to architectural design, from preemptive everyday practices to interventionist counter‐cultural projects, imaginations of the future take concrete form and enjoy a powerful purpose. In this intervention we ask: How is the future invented, planned, renounced and researched? Specifically, how do we analyse the entanglement of temporal and spatial logics against the enveloping imperative of ‘future as crisis’? What is the role of methodology, collaboration and engagement in shaping debates about the future, and how do we research different futures as well as different positionalities within the future? Rather than taking a prescriptive approach, we consider future epistemologies as well as concrete future practices and the ways in which multiple notions of futurity might overlap. Additionally, we consider the standpoint from which different futures are imagined or renounced, and the ways in which entanglements of past, present and future might reflect a struggle on different social fields. Finally, we complicate some of the distinctions that researchers draw between the practices of imagining, planning and producing future scenarios as exclusionary, and modes of navigating and shaping futures that are embedded in everyday lives.
FUTURE OF A DYING RIVER: Bureaucratic Practices and Negotiated Plans of the Yamuna Riverfront
Authors: Naruka Yogita 
Published: September 2022

AbstractIn this essay I analyse the Yamuna riverfront development plan, India's second‐most ambitious riverfront plan after Sabarmati. It constructs a future vision for the Yamuna and aims to integrate it with the city's economy and popular culture. I explore the logic and mechanisms of this futurity with a specific focus on bureaucratic practices and negotiations between the relevant actors. I argue that the logic of the construction of future scenarios lies in the practices of here and now, which are often overshadowed by the grand promises of the spatial plan. I show how un/doing of the future takes place when this plan of the riverfront is revisited repeatedly within different institutional and communication frameworks.
High‐level recombinant protein production with Corynebacterium glutamicum using acetate as carbon source
Authors: Kiefer Dirk , Tadele Lea Rahel , Lilge Lars , Henkel Marius , Hausmann Rudolf 
Published: September 2022

AbstractIn recent years, biotechnological conversion of the alternative carbon source acetate has attracted much attention. So far, acetate has been mainly used for microbial production of bioproducts with bulk applications. In this study, we aimed to investigate the potential of acetate as carbon source for heterologous protein production using the acetate‐utilizing platform organism Corynebacterium glutamicum. For this purpose, expression of model protein eYFP with the promoter systems T7lac and tac was characterized during growth of C. glutamicum on acetate as sole carbon source. The results indicated a 3.3‐fold higher fluorescence level for acetate‐based eYFP production with T7 expression strain MB001(DE3) pMKEx2‐eyfp compared to MB001 pEKEx2‐eyfp. Interestingly, comparative eyfp expression studies on acetate or glucose revealed an up to 83% higher biomass‐specific production for T7 RNAP‐dependent eYFP production using acetate as carbon source. Furthermore, high‐level protein accumulation on acetate was demonstrated for the first time in a high cell density cultivation process with pH‐coupled online feeding control, resulting in a final protein titer of 2.7 g/L and product yield of 4 g per 100 g cell dry weight. This study presents a first proof of concept for efficient microbial upgrading of potentially low‐cost acetate into high‐value bioproducts, such as recombinant proteins.
Medications impact different aspects of the quality of life of patients with systemic lupus erythematosus
Authors: Leong Khai Pang , Tan Joyce Ching‐Wen , Thong Bernard Yu Hor , Lian Tsui Yee , Koh Ee Tzun , Kong Kok Ooi , Law Weng Giap , Chng Hiok Hee , Chan Grace Yin Lai , Chia Faith Li‐Ann , Tan Justina Wei Lynn , Howe Hwee Siew ,   The Tan Tock Seng Hospital (TTSH) Lupus Study Group
Published: September 2022

AbstractPurposeIn this real‐world observational study, we analyzed the effects of different drugs on the quality of life (QoL) of patients with systemic lupus erythematosus (SLE).MethodWe identified patients in our prospective SLE Registry who received new medications. We measure QoL with MOS 36‐Item Short‐Form Health Survey (SF‐36), a generic health questionnaire, and SLEQOL, a disease‐specific instrument. We compared the patients' scores before and after initiation of treatment.ResultsWe identified 259 episodes of drug initiation in 193 SLE patients. SLEQOL registered statistically significant changes with intravenous cyclophosphamide (total score and the domains of physical functioning, activities, and self‐image), mycophenolate (total score, treatment, mood, and self‐image) and azathioprine (total score, activities, and mood), but not with cyclosporin A and hydroxychloroquine. Two SF‐36 subscales (general health and physical functioning) showed statistically significant improvement in the patients who received intravenous cyclophosphamide. Both instruments have floor effect. There was weak correlation between changes in the QoL instruments and the patient assessment of disease activity or an objective disease activity index.ConclusionSLEQOL distinguishes the differential effects on QoL of the various drugs. Treatment with intravenous cyclophosphamide and mycophenolate impacted the highest numbers of domains of SLEQOL, followed by azathioprine, cyclosporin A, and hydroxychloroquine. SLEQOL may be a useful outcome measure in SLE clinical trials.
Invasive area to tumor ratio is a significant prognostic factor for non‐small cell lung cancer
Authors: Motono Nozomu , Mizoguchi Takaki , Ishikawa Masahito , Iwai Shun , Iijima Yoshihito , Uramoto Hidetaka 
Published: September 2022

AbstractBackgroundAlthough T factor is defined as the size of invasive area rather than total tumor size in the eighth edition of the TNM classification, whether the pathological invasive area to tumor ratio (ITR) is a prognostic factor has not yet been evaluated.MethodsIn total, 432 lung adenocarcinoma patients were analyzed, among which 266 patients with pathological stage IA were used to perform a subanalysis.ResultsSmoking status (odds ratio [OR]: 0.43, p = 0.01), neutrophil‐to‐lymphocyte ratio (NLR) (OR: 1.97, p = 0.03), maximum standardized uptake value (SUVmax) (OR: 3.62, p < 0.01), and ITR (OR: 6.76, p < 0.01) were significantly different in univariate analysis. Smoking status (OR: 0.34, p < 0.01), SUVmax (OR: 3.05, p < 0.01), and ITR (OR: 5.44, p < 0.01) were risk factors for recurrence in multivariate analysis. In patients with pathological stage IA disease, smoking status (OR: 0.34, p = 0.03), NLR (OR: 2.30, p = 0.04), SUVmax (OR: 3.63, p < 0.01), pathological invasive area (OR: 4.00, p < 0.01), and ITR (OR: 6.03, p < 0.01) were significantly different in univariate analysis. Smoking status (OR: 0.27, p = 0.02), SUVmax (OR: 3.93, p < 0.01), and ITR (OR: 4.38, p < 0.01) were significant risk factors for recurrence in multivariate analysis.ConclusionsSUVmax and ITR are risk factors for recurrence. These results suggest that SUVmax is important for deciding the indication for limited resection or adjuvant chemotherapy, and ITR is an adaptation criterion for adjuvant chemotherapy for early‐stage lung adenocarcinoma patients.
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice
Authors: Strong Randy , Miller Richard A. , Cheng Catherine J. , Nelson James F. , Gelfond Jonathan , Allani Shailaja Kesaraju , Diaz Vivian , Dorigatti Angela Olsen , Dorigatti Jonathan , Fernandez Elizabeth , Galecki Andrzej , Ginsburg Brett , Hamilton Karyn L. , Javors Martin A. , Kornfeld Kerry , Kaeberlein Matt , Kumar Suja , Lombard David B. , Lopez‐Cruzan Marisa , Miller Benjamin F. , Rabinovitch Peter , Reifsnyder Peter , Rosenthal Nadia A. , Bogue Molly A. , Salmon Adam B. , Suh Yousin , Verdin Eric , Weissbach Herbert , Newman John , Maccchiarini Francesca , Harrison David E. 
Published: September 2022

AbstractMice bred in 2017 and entered into the C2017 cohort were tested for possible lifespan benefits of (R/S)‐1,3‐butanediol (BD), captopril (Capt), leucine (Leu), the Nrf2‐activating botanical mixture PB125, sulindac, syringaresinol, or the combination of rapamycin and acarbose started at 9 or 16 months of age (RaAc9, RaAc16). In male mice, the combination of Rapa and Aca started at 9 months and led to a longer lifespan than in either of the two prior cohorts of mice treated with Rapa only, suggesting that this drug combination was more potent than either of its components used alone. In females, lifespan in mice receiving both drugs was neither higher nor lower than that seen previously in Rapa only, perhaps reflecting the limited survival benefits seen in prior cohorts of females receiving Aca alone. Capt led to a significant, though small (4% or 5%), increase in female lifespan. Capt also showed some possible benefits in male mice, but the interpretation was complicated by the unusually low survival of controls at one of the three test sites. BD seemed to produce a small (2%) increase in females, but only if the analysis included data from the site with unusually short‐lived controls. None of the other 4 tested agents led to any lifespan benefit. The C2017 ITP dataset shows that combinations of anti‐aging drugs may have effects that surpass the benefits produced by either drug used alone, and that additional studies of captopril, over a wider range of doses, are likely to be rewarding.
Different functions of emotion regulation in linking harmony seeking and rejection avoidance to life satisfaction and social support in Germany, Hong Kong, and Japan
Authors: Schunk Fabian , Wong Natalie , Nakao Gen , Trommsdorff Gisela 
Published: September 2022

This study examined whether two facets of interdependence, harmony seeking and rejection avoidance, were differently related to life satisfaction and social support from friends across cultures through the differential use of emotion regulation strategies. Specifically, we propose that individuals who seek harmony and avoid rejection regulate emotions differently to achieve social adaptation in their sociocultural contexts. University students from Germany (n = 129), Hong Kong (n = 136), and Japan (n = 123) completed our online survey. Data were analysed through multigroup structural equation modelling. Across cultures, harmony seeking was positively while rejection avoidance was negatively related to indices of social functioning (life satisfaction or social support). For Germans, emotion regulation (more rumination, less reappraisal, more suppression) completely mediated the associations of rejection avoidance with life satisfaction. Germans may emotionally overreact when fearing rejection, which is reflected in using dysfunctional emotion regulation strategies. In contrast, rejection avoidance was only weakly related to emotional dysregulation among Hong Kong Chinese and Japanese who might be adapted to fearing exclusion due to living in low relational mobility societies. Our findings demonstrate cultural similarities and differences in the interplay of harmony seeking and rejection avoidance with emotion regulation, life satisfaction, and social support.
Adjunctive use of p16 immunohistochemistry for optimizing management of CIN lesions in a high‐risk human papillomavirus‐positive population
Authors: Ebisch Renée M. F. , Rijstenberg L. Lucia , Soltani Gilda Ghazi , van der Horst Judith , Vedder Judith E. M. , Hermsen Meyke , Bosgraaf Remko P. , Massuger Leon F. A. G. , Meijer Chris J. L. M. , Heideman Daniëlle A. M. , van Kemenade Folkert J. , Melchers Willem J. G. , Bekkers Ruud L. M. , Siebers Albert G. , Bulten Johan 
Published: September 2022

AbstractIntroductionImmunostaining with p16INK4a (p16), a tumor‐suppressor surrogate protein biomarker for high‐risk human papillomavirus (hrHPV) oncogenic activity, may complement standard hematoxylin and eosin (H&E) histology review, and provide more objective criteria to support the cervical intraepithelial neoplasia (CIN) diagnosis. With this study we assessed the impact of p16 immunohistochemistry on CIN grading in an hrHPV‐based screening setting.Material and methodsIn this post‐hoc analysis, 326 histology follow‐up samples from a group of hrHPV‐positive women were stained with p16 immunohistochemistry. All H&E samples were centrally revised. The pathologists reported their level of confidence in classifying the CIN lesion.ResultsCombining H&E and p16 staining resulted in a change of diagnosis in 27.3% (n = 89) of cases compared with the revised H&E samples, with a decrease of 34.5% (n = 18) in CIN1 and 22.7% (n = 15) in CIN2 classifications, and an increase of 18.3% (n = 19) in no CIN and 20.7% (n = 19) in CIN3 diagnoses. The level of confidence in CIN grading by the pathologist increased with adjunctive use of p16 immunohistochemistry to standard H&E.ConclusionsThis study shows that adjunctive use of p16 immunohistochemistry to H&E morphology reduces the number of CIN1 and CIN2 classifications with a proportional increase in no CIN and CIN3 diagnoses, compared with standard H&E‐based CIN diagnosis alone. The pathologists felt more confident in classifying the material with H&E and p16 immunohistochemistry than by using H&E alone, particularly during assessment of small biopsies. Adjunctive use of p16 immunohistochemistry to standard H&E assessment of CIN would be valuable for the diagnostic accuracy, thereby optimizing CIN management and possibly decreasing overtreatment.
Intrinsic motivation as a double‐edged sword: Investigating effects on well‐being and the role of flex place practices as moderator to buffer adverse effects
Authors: Stockkamp Mariella , Kuonath Angela , Kühnel Jana , Kennecke Silja , Frey Dieter 
Published: September 2022

AbstractEnsuring employee well‐being is a crucial task for organizations. While previous research has mainly focused on positive effects of intrinsic motivation, in this study, we took a more comprehensive view on intrinsic motivation and work‐related well‐being. More specifically, building on conservation of resources theory, we focused on two facets of work‐related well‐being (job satisfaction and emotional exhaustion) and examined direct (beneficial) and indirect (adverse) effects on well‐being via detachment as an inconsistent mediation model. Furthermore, we took a closer look at how the use of flex place practices (FPPs), giving employees the opportunity to choose from where to work, can attenuate potential adverse effects of high intrinsic motivation. We collected data from 408 employees of a European manufacturer at two points of measurement, the first one before and the second one after the introduction of FPPs. Results showed that intrinsic motivation had a positive direct effect on changes in well‐being, and an adverse indirect effect on changes in well‐being via reduced detachment. For employees using FPPs, this adverse indirect effect was dissolved. This research is among the first to explore potential downsides of intrinsic motivation and the role of FPPs in the functioning of intrinsic motivation.
Laparoscopic internal intestinal drainage of bile lakes in a patient with recurrence of jaundice after laparoscopic revision of Kasai portoenterostomy for biliary atresia: A case report
Authors: Gohda Yousuke , Uchida Hiroo , Hinoki Akinari , Shirota Chiyoe , Sumida Wataru , Makita Satoshi , Okamoto Masamune , Ogata Seiya , Takimoto Aitaro , Takada Shunya , Nakagawa Yoichi , Kato Daiki , Guo Yaohui 
Published: September 2022

AbstractBile lake, of the postoperative complications after Kasai portoenterostomy (PE) for biliary atresia, causes cholangitis that may induce progressive fibrosis of the liver. Standard treatment for bile lakes has not yet been established, but there are reports that surgical internal intestinal drainage for bile lakes effectively prevents cholangitis and maintains jaundice‐free status. In this case, insertion of the percutaneous transhepatic biliary drainage into the bile lake allowed continuous drainage of large volumes of bile juice. However, reoperation following laparotomy increases the surgical risk of subsequent liver transplantation due to postoperative adhesion. Laparoscopic surgery was selected for the patient who was likely to require liver transplantation in the future. In this case, laparoscopic internal intestinal drainage of bile lakes was performed safely by a Cavitron ultrasonic surgical aspirator for the recurrence of jaundice after laparoscopic revision of PE. Cholangitis and jaundice were rapidly resolved after this surgical procedure.
Effect of novel therapeutic medicine swertiamarin from Enicostema axillare in zebrafish infected with Salmonella typhi
Authors: Perumal Sasidharan , Samy MadhanaVigneshwari Gopal , Subramanian Dharaneedharan 
Published: September 2022

AbstractHerbal treatments have been practiced by humans over centuries and therefore possess time‐proven safety. However, it is crucial to evaluate the toxic effects of herbal medicine to confirm their safety, particularly when developing therapeutic drugs. Use of laboratory animals such as mice, rat, and rabbits was considered as gold standard in herbal toxicity assessments. However, in the last few decades, the ethical consideration of using higher vertebrates for toxicity testing has become more controversial. As a possible alternative model involving lower vertebrates such as zebra fish were introduced. Hence in the present study, swertiamain compound isolated from E. axillare was assessed for it antimicrobial activity in zebra fish larvae againt S. typhi. The cumulative mortality rate and bacterial localization in zebra fish larvae were studied. Biochemical markers assays were performed to find the preventive role of the compound during the typhoid infection. The results showed that zebra fish can be successfully used as a model to study typhoid infection and the anti‐bacterial compound swertiamarin used in this study clears the bacterial load and pathogenic symptoms to a great extent.