bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sociodemographic and Reproductive Factors Associated with Breast Cancer: A Case-Control Study in a Cancer Specialized Hospital of Dhaka City, Bangladesh
Authors: Zahed Zerin , Hossain Ahmed 
Published: March 2022

Background: Breast cancer is the most common cancer in women in the world. In Bangladesh, the breast cancer is estimated to have the age-standardized incidence rate of 25.2 per 100,000 females of all ages.
Objective: The objective of this study was to identify the sociodemographic and reproductive factors associated with the development of breast cancer in Bangladesh.
Materials and method: A case control study was conducted on 136 female subjects, in a cancer specialized hospital of Dhaka city (68 subjects for case group with breast cancer and 68 subjects for control group without any known cancer) aged ≥20 years. Data was collected by face to face interview with structured questionnaire. The results were reported by adjusted odd ratios (ORs) and corresponded 95% confidence intervals (CIs). A p-value less than 0.05 were considered statistically significant. Independent factors associated with breast cancer were established using multivariate logistic regression analysis.
Result: Among the reproductive factors, women with the history of hysterectomy are 84% less likely and post-menopausal women are 27.83% more likely to get breast cancer. On sociodemographic background women who received 12+ years of schooling and 6 to 10 years of education are 14.91% and 4.91% more likely to get breast cancer. Women with the monthly family income of 5000 Tk to 25000 Tk are 76% less likely to get breast cancer than women with more monthly family income. Women married for more than 20 years are 7.27% more likely to get cancer. Women with 3 or more children are 81% less likely to get breast cancer than women with fewer children.
Conclusion: Our study suggests that, age, level of education, monthly family income, history of hysterectomy of the patient may play an important role in risk of breast cancer in Bangladeshi women. Further research is needed to better understand the complex interactions between environmental, reproductive and genetic factors.
Delta Med Col J. Jul 2020 8(1): 4-8
Incidental Diagnosis of Bicornuate Uterus in a Lady of 48 Years - A Case Report
Authors: Parveen Rafia , Rahman Shaikh Shofiur 
Published: March 2022

Congenital anomalies of uterus are not very uncommon. Quite a number of women with these anomalies can be totally asymptomatic. In some women, anomalies may be first detected during pregnancy or delivery. Here a case of incidentally diagnosed bicornuate uterus is reported in a lady of 48 years while being treated for breast carcinoma. The patient attended with a lump in her left breast at Delta Medical College Hospital, Dhaka, Bangladesh. She was totally asymptomatic previously and her three children were born preterm without any difficulty. Along with other investigations, abdominal ultrasonogram was done which showed two separate fundal and uterine cavities with single cervix. Bicornuate uterus was confirmed by endovaginal ultrasonogram. Breast carcinoma was treated accordingly.
Delta Med Col J. Jul 2020 8(1): 46-50
Efektivitas Pemberian Intervensi ultrasound Dan Contract Relax Stretching Dalam Manajemen mengelola aktivitas fungsional leher karena Trigger Points pada Kondisi Myofascial Otot Upper Trapezius
Authors: Ismaningsih Ismaningsih , Muawanah Siti , Fitria Santi 
Published: March 2022

Myofascial pain syndrome (MPS) adalah sindrom lokal yang ditandai dengan nyeri,ketegangan otot,sensitivitas berlebihan dan keterbatasan ROM karena trigger points.MPS merupakan penyebab kecacatan sistem muskuloskeletal seperti yang terjadi pada 37% pria dan 65% wanita pada usia 30-60 tahun.keluhan paling umum yaitu MPS.otot trapezius ditetapkan sebagai otot postural dan sangat rentan terhadap aktivitas yang berlebihan.rasa sakitnya bahkan dapat dirasakan selama istirahat dan diperburuk oleh aktivitas.hasil studi terbaru berhipotesis bahwa trapezitis merupakan patogenesis hasil dari overloading dan cidera jaringan otot,yang menyebabkan pemendekan serat otot lokal,hal ini mengakibatkan area jaringan lunak tertekan menerima lebih sedikit oksigen,glukosa,nutrisi,dan mengakumulasi produksi limbah metabolisme tingkat tinggi,yang selanjutnya hasil dari peristiwa ini akan mengakibatkan perubahan jaringan otot,nyeri,serta pengembangan terjadinya trigger point.Penelitian ini bertujuan untuk membuktikan efektivitas pemberian intervensi ultrasound,latihan dan contra rillex stretching sebagai pendekatan fisioterapi dalam manajemen penurunan nyeri pada kondisi myalgia trapezius. Jenis penelitian yang digunakan adalah penelitian quasi experiment dengan desain penelitian pre and post test without control group design. pada kelompok perlakuan ini menggunakan uji Normalitas berdasarkan uji shapiro wilk test pada semua variabel pre test dan post test. pada kelompok data didapatkan nilai rerata sebelum 56.66±5.875 dan nilai P=0.002 sedangkan nilai rerata sesudah 14.66±11.872 dan didapatkan nilai P= 0,009,maka P< 0,05 maka data disimpulkan berdistribusi tidak normal,sehingga pada kelompok perlakuan ini menggunakan uji wilcoxon. hasil perbedaan sebelum dan sesudah intervesi pada Kelompok perlakuan dengan nilai yang signifikan P = 0,001 (P<0.05) dengan nilai rerata 42.00±10.65.yang berarti intervensi perlakuan ultrasound dan contract relax stretching signifikan dalam meningkatkan aktivitas fungsional leher pada myofascial otot upper trapezius.
PENGARUH WAKTU PIROLISIS SERBUK GERGAJI KAYU TERHADAP HASIL ASAP CAIR
Authors: Handayani Ita , Sa’diyah Khalimatus 
Published: March 2022

Penggunaan kayu di Indonesia sebagai bahan baku utama industri mebel sangat besar, sehingga limbah yang dihasilkan seperti serbuk dan potongan-potongan kecil kayu juga banyak. Serbuk gergaji kayu jati digunakan dalam penelitian karena limbah industri mebel ini belum banyak dimanfaatkan oleh masyarakat. Salah satu teknologi aplikatif yang dikembangkan untuk pemanfaatan limbah serbuk gergaji kayu adalah mengolahnya menjadi asap cair. Oleh karena itu dilakukan penelitian pembuatan asap cair ini untuk mengetahui pengaruh variabel waktu pirolisis terhadap hasil asap cair. Pada penelitian ini dilakukan percobaan dengan variasi waktu pemanasan pirolisis dan jenis kayu menjadi asap cair. Variasi waktu yang digunakan adalah 30, 45, 60, 75, dan 90 menit dengan jenis kayu yang digunakan adalah campuran kayu jati dan kayu mahoni bermassa 100 gram dengan rasio massa 50:50. Proses pirolisis dilakukan dengan menggunakan tungku atau kompor dengan setting pemanasan maksimum di kompor. Hasil asap cair dilakukan analisis terhadap volume asap cair, densitas, %yield, nilai pH dan warna yang dihasilkan. Dalam penelitian ini volume asap cair terbesar yang dihasilkan selama 90 menit memiliki densitas sebesar 0,48 g/cm3 dan %yield sebesar 58%. Nilai pH yang dihasilkan yaitu 5 dan produk asap cair berwarna hitam pekat. Hasil asap cair pada penelitian termasuk dalam golongan grade 3. Semakin lama waktu proses pirolisis maka semakin banyak volume asap cair yang dihasilkan.
Analisis Kualitas Suara Dalam Komunikasi Antar IP Phone Pada Jaringan Intranet di Politeknik Negeri Malang
Authors: Krisna Arlisa , Atmadja Martono Dwi , Soelistianto Farida Arinie 
Published: March 2022

IP Phone merupakan salah perangkat pada Voice over Internet Protocol (VoIP) yang dapat menyalurkan suara menggunakan IP. Berbagai tipe IP Phone bermunculan dengan harga dan fitur yang bervariasi, sehingga menimbulkan pertanyaan terkait bagaimana perbandingan kualitas suara pada IP Phone yang dihadirkan oleh berbagai tipe tersebut, mengingat kualitas suara dalam telekomunikasi sangat penting agar tidak menimbulkan kesalahfahaman saat telekomunikasi berlangsung.
Terdapat dua tipe IP Phone pada sistem yang sudah diregistrasikan dengan server sehingga dapat melakukan panggilan dengan range frekuensi 300Hz s/d 3400Hz, kemudian dari komunikasi antar IP Phone terdapat bentuk gelombang sinyal informasi input dan output, respon amplitudo suara terhadap perubahan frekuensi suara serta nilai delay dari pergeseran fasa menggunakan alat ukur Tranmission Test Set dan Oscilloscope yang digunakan untuk mengetahui karakter kualitas suara dalam komunikasi antar IP Phone sesuai hasil uji parameter.
Hasil pengujian sitem dapat disimpulkan bahwa bentuk gelombang sinyal informasi input dan output pada frekuensi suara memiliki bentuk gelombang sinus, namun gelombang output pada IP Phone tipe A frekuensi 300Hz s/d 1100Hz dan IP Phone tipe B frekuensi 300Hz s/d 1300Hz mengalami distorsi, selanjutnya dari hasil nilai Peak to Peak gelombang diketahui adanya penguatan tegangan yaitu semakin besar nilai frekuensi pada input maka akan semakin kecil nilai penguatan tegangan yang dihasilkan. Nilai respon amplitudo terhadap perubahan frekuensi suara dengan nilai amplitudo input -23.5 dBm pada kedua IP Phone memiliki penguatan daya yang semakin kecil ketika nilai frekuensi suara semakin tinggi. Nilai delay yang didapatkan dari pergeseran gelombang input dan output antar IP Phone yaitu kurang dari 150 ms.
Menyingkap Tabir Potensi Fraud Pajak Penghasilan Youtuber Lokal
Authors: Yustin Nur Faizah  , Moh Toyyib  , Tarjo  , Sri Wahyuni  
Published: March 2022

The purpose is to uncover the potential for income tax fraud carried out by local Youtuber with pneumology as the research method. Data was obtained by conducting interviews with Youtuber as research informants. Theoretically, this research produces the concept of the dimensions of tax fraud that will contribute to the development of the science of forensic accounting to understand the behavior of fraudsters towards tax avoidance by the Youtubers.

Abstrak
Penelitian ini bertujuan untuk mengungkap potensi penipuan pajak penghasilan yang dilakukan oleh Youtuber lokal. Studi ini menggunakan metode fenomologi. Data diperoleh dengan melakukan wawancara dengan Youtuber sebagai informan penelitian. Hasil penelian menjelaskan konsep dimensi tax fraud yang akan berkontribusi pada pengembangan ilmu di bidang akuntansi forensik untuk memahami perilaku pelaku fraud terhadap penghindaran pajak oleh Youtuber.
Efektifitas Implementasi Transformasi Organisasi pada Kinerja Organisasi
Authors: Hanif Mauludin  , Enggar Nursasi  , Suhartati Noviana  
Published: March 2022

The research objective is to explain the success of organizational transformation in improving performance. A Balanced Scorecard is used to direct the achievement of organizational performance. Data is analyzed by quantitative descriptive. The results show that the effectiveness of organizational transformation begins from a learning and growth perspective that emphasizes the competence of human resources as agents of change that impact internal business processes more productively. The capacity of marketing and services is getting better so it contributes significantly to increasing revenue. Organizational transformation also brings a big change in the mindset of organizational members, from bureaucracy to entrepreneurship.

Abstrak
Penelitian ini bertujuan untuk menjelaskan keberhasilan transformasi organisasi dalam meningkatkan kinerja organisasi di Balai Inseminasi Buatan Singosari. Balance Scorecard digunakan untuk mengungkap capaian kinerja organisasi. Metode analisis data menggunakan deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa efektivitas transformasi organisasi diawali dari perspektif pembelajaran dan pertumbuhan yang menekankan pada kompetensi sumber daya manusia sebagai agen perubahan yang berdampak pada proses bisnis internal secara lebih produktif. Kapasitas pemasaran dan layanan menjadi semakin baik sehingga berkontribusi signifikan pada peningkatan pendapatan transformasi organisasi juga membawa perubahan besar atas mindset anggota organisasi, dari birokrasi menjadi wirausaha.
Determinan Minat Investasi Saham Generasi Milenial di Masa Pandemi
Authors: Yuliana Sugiarti  , Mawardi Rizal 
Published: March 2022

This study aims to measure the effect of financial literacy, demographic factors (income level, education level, gender), and the perception of return on interest in investing in shares of the millennial generation during the Covid-19 period. The sample used is 255 respondents using the purposive sampling method. The analytical technique used is multiple linear regression. These results show that financial literacy, high-income levels, and perceptions of return have an effect on interest in stock investment. Meanwhile, low-income levels, education levels, and gender have no effect on the millennial generation's interest in investing in shares during the Covid-19 period.

Abstrak
Penelitian ini bertujuan mengukur pengaruh literasi keuangan, faktor demografi (tingkat pendapatan, tingkat pendidikan, jenis kelamin), serta persepsi return pada minat investasi saham generasi milenial di masa Covid-19. Sampel yang dipergunakan berjumlah 255 responden mempergunakan metode purposive sampling. Teknik penganalisisan yang dipergunakan ialah regresi linier berganda. Hasil ini menampilkan literasi keuangan, tingkat pendapatan tinggi, dan persepsi return berpengaruh terhadap minat investasi saham. Sedangkan tingkat pendapatan, tingkat pendidikan, serta jenis kelamin rendah tidak berpengaruh pada minat investasi saham generasi milenial di masa Covid-19.
Exploring Human Resource Competence and Management Performance of a Village-Owned Enterprise
Authors: Putri Nugrahaningsih  , Andi Asrihapsari  , Vidia Ayu Satyanovi  , Labbaika Dwi Ayu Rahmawati  , Denty Arista  , Lina Nur Ardila  
Published: March 2022

This study aims at investigating the competence of human resources of BUMDes Blulukan in managing the business that leads to green entrepreneurship. This study uses a qualitative descriptive method using interviews and questionnaires as a data collection technique The conclusion of the study shows that the human resources in the BUMDes have adequate competence and level of understanding on green entrepreneurship, as seen from the effort in managing waste by creating products with higher selling points to improve the village communities' welfare in yielding innovative products from waste and generating income for village community products with high-selling values.
AbstrakTujuan penelitian ini adalah melihat kemampuan Sumber Daya Manusia studi kasus pada BUMDES Blulukan dalam mengelola bisnis yang mengarah kepada green entrepreneurship. Penelitian ini menggunakan metode deskriptif kualitatif dengan cara wawancara dan penyebaran kuesioner sebagai teknik pengumpulan datanya. Kesimpulan penelitian menunjukkan bahwa kemampuan dan tingkat pemahaman SDM BUMDES terkait green entrepreneurship sudah cukup baik dengan melakukan pemanfaatan pengelolaan sampah menjadi nilai jual yang dapat meningkatkan kesejahteraan desa pada produk inovasi berupa pemanfaatan limbah sampah yang sebelumnya menjadi keresahan desa diolah menjadi produk yang menghasilkan nilai jual.
Hepatic Epigenetic Reprogramming After Liver Resection in Offspring Alleviates the Effects of Maternal Obesity
Authors: Simino Lais A. de Paula , Fontana Marina Figueiredo , de Fante Thais , Panzarin Carolina , Ignacio-Souza Letícia Martins , Milanski Marciane , Torsoni Marcio Alberto , Desai Mina , Ross Michael G. , Torsoni Adriana Souza 
Published: March 2022

Obesity has become a public health problem in recent decades, and during pregnancy, it can lead to an increased risk of gestational complications and permanent changes in the offspring resulting from a process known as metabolic programming. The offspring of obese dams are at increased risk of developing non-alcoholic fatty liver disease (NAFLD), even in the absence of high-fat diet consumption. NAFLD is a chronic fatty liver disease that can progress to extremely severe conditions that require surgical intervention with the removal of the injured tissue. Liver regeneration is necessary to preserve organ function. A range of pathways is activated in the liver regeneration process, including the Hippo, TGFβ, and AMPK signaling pathways that are under epigenetic control. We investigated whether microRNA modulation in the liver of the offspring of obese dams would impact gene expression of Hippo, TGFβ, and AMPK pathways and tissue regeneration after partial hepatectomy (PHx). Female Swiss mice fed a standard chow or a high-fat diet (HFD) before and during pregnancy and lactation were mated with male control mice. The offspring from control (CT-O) and obese (HF-O) dams weaned to standard chow diet until day 56 were submitted to PHx surgery. Prior to the surgery, HF-O presented alterations in miR-122, miR-370, and Let-7a expression in the liver compared to CT-O, as previously shown, as well as in its target genes involved in liver regeneration. However, after the PHx (4 h or 48 h post-surgery), differences in gene expression between CT-O and HF-O were suppressed, as well as in microRNA expression in the liver. Furthermore, both CT-O and HF-O presented a similar regenerative capacity of the liver within 48 h after PHx. Our results suggest that survival and regenerative mechanisms induced by the partial hepatectomy may overcome the epigenetic changes in the liver of offspring programmed by maternal obesity.
Right Heart Chambers Longitudinal Strain Provides Enhanced Diagnosis and Categorization in Patients With Pulmonary Hypertension
Authors: Espinola-Zavaleta Nilda , Antonio-Villa Neftali Eduardo , Guerra Enrique C. , Nanda Navin C. , Rudski Lawrence , Alvarez-Santana Ricardo , Camacho-Camacho Gyssele , Aranda-Fraustro Alberto , Cossio-Aranda Jorge , Zamora Karina , Oregel-Camacho Diego , Armenta-Moreno Javier Ivan , Berarducci Joaquin , Alexanderson-Rosas Erick 
Published: March 2022

BackgroundIncreased systolic pulmonary arterial pressure (sPAP) could lead to the mechanical dysfunction and myocardial fibrosis of the right heart chambers. Echocardiographic strain analysis has not been adequately studied in patients with pulmonary hypertension (PH).Study design and methodsA cross-sectional cohort of patients with suspected PH and echocardiographic strain evaluation was recruited. The cut-off values of peak tricuspid regurgitation velocity (TRV) with the low probability of PH (≤2.8 m/s), intermediate probability (2.9–3.4 m/s, without other echo PH signs), and high probability of PH (2.9–3.4 m/s with other echo PH signs and &gt;3.4 m/s) categories were studied by right ventricular and right atrial (RA) strain analysis in a sample of 236 patients.ResultsThe results showed that 58 (56.9%) patients had low, 15 (14.7%) had intermediate, and 29 (28.4%) had a high probability of PH. We observed a negative association between right ventricular free wall strain (RV-FWS) and atrial global strain with sPAP. With the increase in PH severity, RA reservoir, conduit, and contraction (booster) strain values decreased. The identified cut-off values of strain parameters had an adequate ability to detect PH severity categories. In addition, the post-mortem biopsies of right heart chambers from subjects with known severe PH were analyzed to quantify myocardial fibrosis. Our sample of right heart biopsies (n = 12) demonstrated an association between increased sPAP before death and right ventricular and RA fibrosis.ConclusionMechanical dysfunction and fibrosis in the right chambers are associated with increased sPAP. Right ventricular and atrial strain could provide enhancement in the diagnosis and categorization of subjects with suspected PH.
Diastolic Plateau – Invasive Hemodynamic Marker of Adverse Outcome Among Left Ventricular Assist Device Patients
Authors: Grupper Avishay , Kodesh Afek , Lavee Jacob , Fefer Paul , Barbash Israel M. , Elian Dan , Kogan Alexander , Morgan Avi , Segev Amit , Maor Elad 
Published: March 2022

BackgroundDiastolic plateau is an invasive hemodynamic marker of impaired right ventricular (RV) diastolic filling. The purpose of the current analysis was to evaluate the prognostic importance of this sign in left ventricular assist device (LVAD) patients.MethodsThe analysis included all LVAD patients who received continuous-flow LVAD (HeartMate 3) at the Sheba medical center and underwent right heart catheterization (RHC) during follow up post-LVAD surgery. Patients were dichotomized into 2 mutually exclusive groups based on a plateau duration cutoff of 55% of diastole. The primary end point of the current analysis was the composite of death, heart transplantation, or increase in diuretic dosage in a 12-month follow-up period post-RHC.ResultsStudy cohort included 59 LVAD patients with a mean age of 57 (IQR 54–66) of whom 48 (81%) were males. RHC was performed at 303 ± 36 days after LVAD surgery. Patients with and without diastolic plateau had similar clinical, echocardiographic, and hemodynamic parameters. Kaplan–Meier survival analysis showed that the cumulative probability of event at 1 year was 65 ± 49% vs. 21 ± 42% for primary outcomes among patients with and without diastolic plateau (p Log rank &lt; 0.05 for both). A multivariate model with adjustment for age, INTERMACS score and ischemic cardiomyopathy consistently showed that patients with diastolic plateau were 4 times more likely to meet the study composite end point (HR = 4.35, 95% CI 1.75–10.83, p = 0.002).ConclusionDiastolic plateau during RHC is a marker of adverse outcome among LVAD patients.
The Changes of Lipidomic Profiles Reveal Therapeutic Effects of Exenatide in Patients With Type 2 Diabetes
Authors: Zhang Lin , Hu Yanjin , An Yu , Wang Qiu , Liu Jia , Wang Guang 
Published: March 2022

ObjectiveExenatide has been demonstrated beneficial effects on patients with type 2 diabetes mellitus (T2DM) regarding lipid metabolism. However, the potential mechanism remains unclear. We used a lipidomic approach to evaluate lipid changes in response to treatment with exenatide in T2DM patients.MethodsSerum lipidomic profiles of 35 newly diagnosed T2DM patients (before and after exenatide treatment) and 20 age-matched healthy controls were analyzed by ultrahigh-performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry.ResultsA total of 45 lipid species including sphingomyelins (SMs), ceramides (CERs), lysophosphatidylcholines (LPCs), phosphatidylethanolamines (PEs), lysophosphatidylethanolamines (LPEs) and phosphatidylcholines (PCs) were identified in all participants. Compared to the healthy controls, 13 lipid species [SM (d18:1/18:0, d18:1/18:1), Cer (d18:1/18:0, d18:1/16:0, d18:1/20:0, d18:1/24:1), LPC (15:0, 16:0, 17:0), PC (19:0/19:0), LPE (18:0) and PE (16:0/22:6, 18:0/22:6)] were markedly increased in the T2DM group, while PE (17:0/17:0) and PC (18:1/18:0) were decreased (P &lt; 0.05). The serum SM (d18:1/18:0, d18:1/18:1), LPC (16:0), and LPE (18:0) were significantly decreased after exenatide treatment, which was accompanied by the amelioration of lipids and glycemic parameters (TC, LDL-C, ApoA-I, FCP and HbA1c) in T2DM patients. The chord diagrams showed distinct correlation patterns between lipid classes and subclasses among healthy controls, T2DM patients before and after exenatide treatment.ConclusionOur results revealed that the therapeutic benefits of exenatide on T2DM might be involved in the improved lipid metabolism, especially SM, LPC, and LPE.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT03297879.