bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return to work after acute myocardial infarction with cardiogenic shock: a Danish nationwide cohort study
Authors: Lauridsen Marie D , Rørth Rasmus , Butt Jawad H , Schmidt Morten , Weeke Peter E , Kristensen Søren L , Møller Jacob E , Hassager Christian , Kjærgaard Jesper , Torp-Pedersen Christian , Gislason Gunnar , Køber Lars , Fosbøl Emil L 
Published: March 2022

Abstract

Background
Physical and mental well-being after critical illness may be objectified by the ability to work. We examined return to work among patients with myocardial infarction (MI) by cardiogenic shock (CS) status.

Methods
Danish nationwide registries were used to identify patients with first-time MI by CS status between 2005 and 2015, aged 18–63 years, working before hospitalization and discharged alive. Multiple logistic regression models were used to compare groups.

Results
We identified 19 799 patients with MI of whom 653 had CS (3%). The median age was similar for patients with and without CS (53 years, interquartile range 47–58). One-year outcomes in patients with and without CS were as follows: 52% vs. 83% returned to work, 41% vs. 16% did not and 6% vs. 1% died. The adjusted odds ratio (OR) of returning to work was 0.53 [95% confidence limit (CI): 0.42–0.66]. In patients with CS, males and patients surviving OHCA were more likely to return to work (OR: 1.83, 95% CI: 1.15–2.92 and 1.55, 95% CI: 1.00–2.40, respectively), whereas prolonged hospitalization (OR: 0.38, 95% CI: 0.22–0.65) and anoxic brain damage (OR: 0.36, 95% CI: 0.18–0.72) were associated with lower likelihood of returning to work.

Conclusion
In patients with MI discharged alive, approximately 80% of those without CS returned to work at 1-year follow-up in contrast to 50% of those with CS. Among patients with CS, male sex and OHCA survivors were markers positively related to return to work, whereas prolonged hospitalization and anoxic brain damage were negatively related markers.
Recurrent mitral regurgitation with haemolytic anaemia after MitraClip procedure: an autopsy case report
Authors: Hoshino Naoki , Muramatsu Takashi , Tsukamoto Tetsuya , Yamada Akira 
Published: March 2022

Abstract

Background
Transcatheter edge-to-edge mitral valve repair (TMVr) has been developed as an alternative therapeutic approach to patients with severe mitral regurgitation (MR) at high-surgical risks. Single leaflet device attachment (SLDA) is a well-known complication after the TMVr procedure, while an autopsy case experiencing haemolytic anaemia has been scarcely reported.

Case summary
A 79-year-old woman presented with New York Heart Association Class 3 congestive heart failure due to severe MR. The Heart Team planned TMVr using the MitraClip considering a high-surgical risk due to the history of open-chest surgery. The procedure was successful with two clips and a significant reduction of MR was confirmed. On the 12th day after the procedure, congestive heart failure was worsened and a transthoracic echocardiogram revealed severe MR suggestive of SLDA. Blood test showed normocytic anaemia with serum lactate dehydrogenase level elevation and renal function deterioration. We diagnosed as mechanical haemolysis induced by recurrent MR because of a decrease in serum haptoglobin level and the presence of schizocyte in the blood smear. Despite our intensive medical treatment, she died on the 119th day after the procedure. The pathological autopsy demonstrated that the ruptured leaflet was thickened with layered structure and severe fibrosis, while there were no findings of calcification, vegetations, or abscesses.

Discussion
Single leaflet device attachment and subsequent mechanical haemolysis are rare but fatal complications after TMVr with the MitraClip. Not only degenerative MR but also functional MR may be associated with valve leaflet degeneration. A possibility of mechanical haemolysis should be considered when recurrent MR is observed after TMVr.
Determinants of label non-adherence to non-vitamin K oral anticoagulants in patients with newly diagnosed atrial fibrillation
Authors: Seelig J , Trinks-Roerdink E M , Chu G , Pisters R , Theunissen L J H J , Trines S A , Pos L , Kirchhof C J H J , de Jong S F A M S , den Hartog F R , van Alem A P , Polak P E , Tieleman R G , van der Voort P H , Lenderink T , Otten A M , de Jong J S S G , Gu Y L , Luermans J G L M , Kruip M J H A , Timmer S A J , de Vries T A C , Cate H ten , Geersing G J , Rutten F H , Huisman M V , Hemels M E W 
Published: March 2022

Abstract

Aims
To evaluate the extent and determinants of off-label non-vitamin K oral anticoagulant (NOAC) dosing in newly diagnosed Dutch AF patients.

Methods and results
In the DUTCH-AF registry, patients with newly diagnosed AF (&lt;6 months) are prospectively enrolled. Label adherence to NOAC dosing was assessed using the European Medicines Agency labelling. Factors associated with off-label dosing were explored by multivariable logistic regression analyses. From July 2018 to November 2020, 4500 patients were registered. The mean age was 69.6 ± 10.5 years, and 41.5% were female. Of the 3252 patients in which NOAC label adherence could be assessed, underdosing and overdosing were observed in 4.2% and 2.4%, respectively. In 2916 (89.7%) patients with a full-dose NOAC recommendation, 4.6% were underdosed, with a similar distribution between NOACs. Independent determinants (with 95% confidence interval) were higher age [odds ratio (OR): 1.01 per year, 1.01–1.02], lower renal function (OR: 0.96 per ml/min/1.73 m2, 0.92–0.98), lower weight (OR: 0.98 per kg, 0.97–1.00), active malignancy (OR: 2.46, 1.19–5.09), anaemia (OR: 1.73, 1.08–2.76), and concomitant use of antiplatelets (OR: 4.93, 2.57–9.46). In the 336 (10.3%) patients with a reduced dose NOAC recommendation, 22.9% were overdosed, most often with rivaroxaban. Independent determinants were lower age (OR: 0.92 per year, 0.88–0.96) and lower renal function (OR: 0.98 per ml/min/1.73 m2, 0.96–1.00).

Conclusion
In newly diagnosed Dutch AF patients, off-label dosing of NOACs was seen in only 6.6% of patients, most often underdosing. In this study, determinants of off-label dosing were age, renal function, weight, anaemia, active malignancy, and concomitant use of antiplatelets.
Genome sequencing of Pseudomonas aeruginosa strain M2 illuminates traits of an opportunistic pathogen of burn wounds
Authors: Verhoeve Victoria I , Brammer Jerod A , Driscoll Timothy P , Kambouris Adrienne R , Rasko David A , Cross Alan S , Gillespie Joseph J 
Published: March 2022

Abstract
Pseudomonas aeruginosa is a Gram-negative nosocomial pathogen and one of the most prevalent organisms isolated from burn wounds worldwide. Pseudomonas aeruginosa strain M2 (O5 serotype, type B flagella) is utilized for examining the murine model associated with burns. Pseudomonas aeruginosa M2 is similar in lethality to common laboratory P. aeruginosa strains when infecting CD-1 mice. Conversely, we recently showed that, relative to these strains, P. aeruginosa M2-infected mice are more susceptible to sepsis and demonstrate a 6-log reduction in LD50 from subcutaneous infection at the infection site directly after 10% total body surface area burn. To better understand this striking phenotypic difference from other P. aeruginosa strains employed in burn models, we sequenced the P. aeruginosa M2 genome. A total of 4,136,641 read pairs were obtained, providing an average genome coverage of 97.5X; subsequent assembly yielded a draft genome with 187 contigs comprising 6,360,304 bp with a G + C content of 66.45%. Genome-based phylogeny estimation of 92 P. aeruginosa strains placed P. aeruginosa M2 with P. aeruginosa-12-4-4(59), a nonairway clinical strain isolated from the blood culture of a burn patient. Phylogenomic analyses identified genes shared between P. aeruginosa M2 and P. aeruginosa 14, another strain exhibiting increased lethality in thermal tissues, as well as P. aeruginosa M2 unique genes with diverse functions like degradation of toxic aromatic compounds, iron scavenging, swarming motility and biofilm formation, defense against invasive DNA, and host assault. Predicted lateral gene transfers illuminate proteins heretofore uncharacterized for roles in P. aeruginosa biology. Our work yields a rich resource for assessing P. aeruginosa genes required for increased lethality in burn tissue seroma.
Does labral treatment technique influence the outcome of FAI surgery? A matched-pair study of labral reconstruction versus repair and debridement with a follow-up of 10 years
Authors: Laboudie Pierre , Gauthier Paul , Kreviazuk Cheryl , Beaulé Paul E 
Published: March 2022

ABSTRACT
The aim of this study was to analyze the long-term clinical outcomes of labral reconstruction in patients undergoing femoro-acetabular impingement (FAI) surgery and compare them with labral repair and debridement. This is a single-center, single-surgeon, retrospective match-paired study from a prospectively collected hip preservation database. All patients underwent a hip surgical dislocation for FAI surgery. Eight patients underwent labral reconstruction with the ligamentum teres and were matched on sex, age and body mass index with 24 labral repair and 24 labral debridement (1:3). Failure was defined as conversion to total hip replacement (THR) and patient-reported outcome measures (PROMs) were collected. Mean follow-up was 9.8 years ±2.6 (5.2–13.9). There was a significant improvement in postoperative PROMs in the three groups regarding the WOMAC total, WOMAC function, HOOS-QoL, HOOS-ADL and HOOS-SRA (P &lt; 0.05). There was no statistical difference between the three groups regarding postoperative PROMs and change in PROMs (P &gt; 0.05). A total of 10 hips underwent joint replacement surgery at a mean time of 7.9 ± 3.5 years (2.4–12). There was no statistically significant difference between the three groups regarding the conversion rate to THR (P = 0.64) or time between surgery and conversion to THR (P = 0.15). Compared to a match-pair group of labral repair and debridement, labral reconstruction with ligamentum teres provides similar survival with conversion to a THR as an endpoint, as well as similar improvement in PROMs. Labral treatment can be safely adapted at the nature of the labral lesion with a treatment ‘à la carte’.
Mammographic Density Decline, Tamoxifen Response, and Prognosis by Molecular Characteristics of Estrogen Receptor–Positive Breast Cancer
Authors: Abubakar Mustapha , Mullooly Maeve , Nyante Sarah , Pfeiffer Ruth M , Aiello Bowles Erin J , Cora Renata , Bodelon Clara , Butler Eboneé , Butcher Donna , Sternberg Lawrence , Troester Melissa A , Weinmann Sheila , Sherman Mark , Glass Andrew G , Berrington de Gonzalez Amy , Gierach Gretchen L 
Published: March 2022

Abstract

Background
Mammographic breast density (MBD) decline post-tamoxifen initiation is a favorable prognostic factor in estrogen receptor (ER)–positive breast cancer (BC) and has potential utility as a biomarker of tamoxifen response. However, the prognostic value of MBD decline may vary by molecular characteristics among ER–positive patients.

Methods
We investigated associations between MBD decline (≥10% vs &lt;10%) and breast cancer–specific mortality (BCSM) among ER–positive breast cancer patients aged 36-87 years at diagnosis treated with tamoxifen at Kaiser Permanente Northwest (1990-2008). Patients who died of BC (case patients; n = 62) were compared with those who did not (control patients; n = 215) overall and by tumor molecular characteristics (immunohistochemistry [IHC]–based subtype [luminal A–like: ER–positive/progesterone receptor [PR]–positive/HER2–negative/low Ki67; luminal B–like: ER–positive and 1 or more of PR–negative, HER2–positive, high Ki67] and modified IHC [mIHC]–based recurrence score of ER/PR/Ki67). Percent MBD was measured in the unaffected breast at baseline mammogram (mean = 6 months before tamoxifen initiation) and follow-up (mean = 12 months post-tamoxifen initiation). Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were computed from logistic regression models. All statistical tests were 2-sided.

Results
MBD decline was statistically significantly associated with reduced risk of BCSM overall (OR = 0.38, 95% CI = 0.15 to 0.92). This association was, however, stronger among women with aggressive tumor characteristics including luminal B–like (OR = 0.17, 95% CI = 0.04 to 0.73) vs A–like (OR = 0.74, 95% CI = 0.19 to 2.92); large (OR = 0.26, 95% CI = 0.08 to 0.78) vs small (OR = 0.41, 95% CI = 0.04 to 3.79) tumors; PR–negative (OR = 0.02, 95% CI = 0.001 to 0.37) vs PR–positive (OR = 0.50, 95% CI = 0.18 to 1.40) disease; and high (OR = 0.25, 95% CI = 0.07 to 0.93) vs low (OR = 0.44, 95% CI = 0.10 to 2.09) mIHC3 score.

Conclusion
The findings support MBD decline as a prognostic marker of tamoxifen response among patients with aggressive ER–positive BC phenotypes, for whom understanding treatment effectiveness is critical.
Repair of patellar tendon rupture after total knee arthroplasty using knotless suture bridge technique: a case report
Authors: Seki Toshihiro , Shiigi Eiichi , Seki Kazushige , Yoshida Koji , Okazaki Tomoya , Uehara Kazuya , Tanaka Hiroshi , Sakai Takashi 
Published: March 2022

Abstract
Few studies have reported on the use of knotless suture anchors to treat patellar tendon rupture from tibial tuberosity after total knee arthroplasty (TKA). We report a case of patellar tendon rupture in an 82-year-old female. She fell 8 weeks after bilateral TKA and presented with a patellar tendon rupture. A knotless suture anchor and a fully threaded Twist-In knotless anchor with flat-braided suture were used to repairing the patellar tendon. Complications related to the extension mechanism after TKA can lead to disastrous consequences. This surgical procedure is a safe and good treatment option to repair patellar tendon rupture after TKA.
Teratocarcinosarcoma of the cheek: a case report
Authors: El Ochi Mohamed Reda , Essaoudi Amine , El Ktaibi Abderrahim , Damiri Amal , Chahdi Hafsa , Oukabli Mohamed 
Published: March 2022

Abstract
Teratocarcinosarcoma is a rare and aggressive malignant tumor of uncertain histogenesis. It presents &lt;1% of all cancers and ~3% of malignant tumors of the head and neck. It arises commonly from the nasal cavity and paranasal sinuses. To the best of our knowledge, only one case has been reported in the oral cavity. A 46-year-old woman presented with 3-week history of a rapidly growing tumor in the inner side of the left cheek. Physical examination revealed an ulcerating mass measuring 4 × 3.5 cm. An excisional biopsy was performed. Histological analysis revealed a teratocarcinosrcoma. The patient was treated by combined chemotherapy and radiation therapy. No recurrence was noted 6 months after treatment. The prognosis is poor.
Chiari Malformation and Migraine
Authors: Newman Lawrence C. , Levin Morris , Halker Singh Rashmi B. , Michael Rebecca L. 
Published: March 2022

Abstract
Chiari malformations are congenital deformities that are thought to arise from intrauterine underdevelopment of the posterior cranial fossa. The resultant crowding of the posterior fossa causes a downward displacement of the cerebellar tonsils through the foramen magnum and into the upper cervical spinal canal. This chapter on Chiari malformation and migraine provides a review of typical findings on history, exam, and imaging when a patient presents with a Chiari malformation. Because individuals who have a primary headache disorder such as migraine can also present with Chiari malformation, the chapter also provides commentary on tips to distinguish between the two headache types.
New Daily Persistent Headache
Authors: Newman Lawrence C. , Levin Morris , Halker Singh Rashmi B. , Michael Rebecca L. 
Published: March 2022

Abstract
This chapter investigates new daily persistent headache (NDPH), which is a rare primary headache disorder characterized by persistent headache with a particular profile because it starts one day with a clearly remembered onset and continues in a daily pattern. NDPH can have either chronic migraine or chronic tension-type headache features. Only a sudden onset and persistence are required for the diagnosis of NDPH. The most important first step in these cases is to exclude secondary causes; a number of occult mimics must be ruled out. However, treatment of NDPH is generally never fully effective. In clinical practice, most headache specialists treat NDPH based on the prominent headache phenotype, whether migrainous or tension-type. Medication overuse is frequently a problem, for obvious reasons, and must be dealt with in order to have a chance at successful outcome.
Cough Headache
Authors: Newman Lawrence C. , Levin Morris , Halker Singh Rashmi B. , Michael Rebecca L. 
Published: March 2022

AbstractHeadaches that occur with coughing, sneezing, straining, or exertion should prompt a search for lesions within the posterior fossa, craniocervical junction, or cerebrospinal fluid pathways. Primary cough headache is uncommon. Within seconds of coughing, sneezing, straining, or other Valsalva maneuvers, an immediate headache is experienced. Primary exercise headache occurs with exertional effort, as may occur during physical exercise such as running or other forms of cardio. The headache is of sudden onset and often bilateral in location, but unlike cough headache, the pain is often pulsatile and of longer duration. This chapter describes the typical presentation of the cough headache diagnosis as well as the related condition of primary exercise headache. The chapter outlines the workup that should be undertaken when patients present with cough headache, and it also shares treatment options.
Cervicogenic Headache
Authors: Newman Lawrence C. , Levin Morris , Halker Singh Rashmi B. , Michael Rebecca L. 
Published: March 2022

Abstract
This chapter focuses on cervicogenic headache, a secondary headache disorder in which pain is referred to the head from a source in the cervical spine. It can be challenging to diagnose, in part because neck pain may not be a prominent part of the presentation. One diagnosis which should not be missed is dissection of the vertebral or internal carotid arteries, which can present with neck pain and/or headache. Lesions in the posterior cranial fossa should be eliminated as well. Diagnostic imaging of the cervical spine may be helpful in some cases, although is often not necessary in diagnosing cervicogenic headache. For probable cervicogenic headache, or in circumstances in which diagnostic blocks are not an option, exercises with or without manual therapy seem to be the best options among conservative therapy. Pharmacological treatments are not well established, but neuropathic pain medications, tricyclic antidepressants, and muscle relaxants have been employed.
Medication Overuse
Authors: Newman Lawrence C. , Levin Morris , Halker Singh Rashmi B. , Michael Rebecca L. 
Published: March 2022

Abstract
Refractory daily headache is usually the result of misdiagnosis, inappropriate or inadequate pharmacotherapy, or failure to identify and treat coexisting exacerbating factors. Refractory daily headache commonly occurs in the setting of medication overuse. This chapter on medication overuse describes the phenomenon of headache worsening in frequency and severity when acute medications are taken too frequently. The chapter provides the definition of medication overuse headache, and it discusses management options when medication overuse is a concern. The chapter also shares the 2020 Quality Improvement headache updates from the American Headache Society and the American Academy of Neurology that provide new clinical recommendations on how to address medication overuse in the context of the underlying primary headache disorder.
Hemicrania Continua
Authors: Newman Lawrence C. , Levin Morris , Halker Singh Rashmi B. , Michael Rebecca L. 
Published: March 2022

Abstract
Hemicrania continua is characterized by a unilateral, continuous headache of mild to moderate intensity. Patients usually describe this baseline discomfort as dull, aching, or pressing, and it is not associated with other symptoms. The pain is maximal in the ocular, temporal, and maxillary regions. Superimposed upon this background discomfort, exacerbations of more severe pain, lasting 20 minutes to several days, are experienced by the majority of sufferers. This chapter provides a description of this side-locked, continuous trigeminal autonomic cephalalgia. It presents details on the clinical presentation of this disorder and provides tips on how to distinguish it from other headache conditions. In addition, the chapter provides a summary of treatment options.
Occipital Neuralgia
Authors: Newman Lawrence C. , Levin Morris , Halker Singh Rashmi B. , Michael Rebecca L. 
Published: March 2022

Abstract
This chapter assesses occipital neuralgia (ON), which can occur after posterior head trauma or whiplash, presumably due to the propensity for damage to the relatively superficial greater occipital nerve (GON), which can easily be compressed against the skull. It has been demonstrated that ON occurs more commonly in patients with other coexisting headache disorders. ON presents with stabbing pain in the occipital region as well as tenderness, dysesthesia, or allodynia over the affected nerve branch. Differential diagnosis includes pathology in the region of the upper cervical spine, craniocervical junction, or posterior fossa. The most useful initial treatment of ON is also diagnostic—anesthetic blockade of the GON. If local anesthesia of the GON is effective but pain returns, subsequent GON blocks may prove longer lasting.
Combined Hormonal Contraceptives and Migraine
Authors: Newman Lawrence C. , Levin Morris , Halker Singh Rashmi B. , Michael Rebecca L. 
Published: March 2022

Abstract
This chapter on combined hormonal contraceptives and migraine focuses on the current discussions that revolve around prescribing hormonal contraceptives to women who have migraine. Because aura is a stroke risk factor, there is controversy regarding whether women who have migraine with aura may take estrogen-containing contraceptives. Aura is a positive focal symptom, spreading gradually over 5 minutes, lasting 5–60 minutes, and often followed by a headache within 60 minutes. Visual aura is the most common. A diagnosis of aura can double a woman’s baseline stroke risk; this risk can increase further if aura occurs frequently. This chapter discusses this topic in detail and leaves the reader well informed of the contemporary issues.
Abdominal Migraine
Authors: Newman Lawrence C. , Levin Morris , Halker Singh Rashmi B. , Michael Rebecca L. 
Published: March 2022

Abstract
This chapter examines abdominal migraine, which is classified as an episodic syndrome that may be associated with migraine although headache is absent. This syndrome typically affects children aged 3–12 years. Another episodic syndrome that causes recurrent gastrointestinal disturbance is cyclical vomiting syndrome. These syndromes describe periodic symptoms in children who commonly have a family history of migraine, have co-occurrence of migraine, or have an increased risk of clinical evolution to migraine in later years. Abdominal migraine has been reported in adults; however, it is believed to be much less common. The diagnosis of abdominal migraine is made clinically, but if any red flags are raised—including failure to thrive, unexplained or recurrent fevers, chronic diarrhea, anemia, or family history of inflammatory bowel disease—concern should be raised for an alternative diagnosis and diagnostic evaluation should ensue. Treatment strategies are often extrapolated from migraine treatment and should include both pharmacological and nonpharmacological options.