bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-Ca2+ axis
Authors: Jing Guoqing , Zuo Jing , Fang Qing , Yuan Min , Xia Yun , Jin Qiyan , Liu Yuping , Wang Yanlin , Zhang Zongze , Liu Wanhong , Wu Xiaojing , Song Xuemin 
Published: September 2022

Abstract
Background
Microglia pyroptosis-mediated neuroinflammation is thought to be the crucial pathogenesis of sepsis-associated encephalopathy (SAE). Erbin has been reported to be associated with various inflammatory diseases. However, the role of Erbin in SAE and the relationship between Erbin and microglia pyroptosis are unknown. In this study, we investigated the promising role and underlying molecular mechanism of Erbin in the regulation of microglia pyroptosis.

Methods
WT and Erbin knockout mice underwent cecum ligation perforation (CLP) to induce SAE. Primary mouse microglia and BV2 cells were treated with LPS/nigericin in vitro. Behavioral tests were performed to evaluate cognitive function. Nissl staining and transmission electron microscopy were used to assess histological and structural lesions. ELISA and qPCR were carried out to detect neuroinflammation. Western blot and immunofluorescence were used to analyze protein expression. Flow cytometry and confocal microscopy were utilized to observe the Ca2+ changes in the cytoplasm and endoplasmic reticulum (ER). To further explore the underlying mechanism, STF083010 was administered to block the IRE1α/Xbp1s pathway.

Results
Erbin deletion resulted in more pronounced neuronal damage and cognitive impairment in mice that underwent CLP. Erbin knockout promoted microglial pyroptosis and inflammatory cytokines secretion in vivo and in vitro, which was mediated by activation of the IRE1α/Xbp1s. Treatment with the selective inhibitor STF083010 significantly inhibited IRE1α/Xbp1s pathway activity, decreased intracytoplasmic Ca2+, attenuated microglial pyroptosis, reduced pro-inflammatory cytokine secretion, lessened neuronal damage, and improved cognitive function.

Conclusions
In SAE, Erbin inhibits IRE1/Xbp1s pathway activity and reduces the ER Ca2+ influx to the cytoplasm, reducing microglial pyroptosis.
Determining optimal mobile neurofeedback methods for motor neurorehabilitation in children and adults with non-progressive neurological disorders: a scoping review
Authors: Behboodi Ahad , Lee Walker A. , Hinchberger Victoria S. , Damiano Diane L. 
Published: September 2022

Abstract
Background
Brain–computer interfaces (BCI), initially designed to bypass the peripheral motor system to externally control movement using brain signals, are additionally being utilized for motor rehabilitation in stroke and other neurological disorders. Also called neurofeedback training, multiple approaches have been developed to link motor-related cortical signals to assistive robotic or electrical stimulation devices during active motor training with variable, but mostly positive, functional outcomes reported. Our specific research question for this scoping review was: for persons with non-progressive neurological injuries who have the potential to improve voluntary motor control, which mobile BCI-based neurofeedback methods demonstrate or are associated with improved motor outcomes for Neurorehabilitation applications?

Methods
We searched PubMed, Web of Science, and Scopus databases with all steps from study selection to data extraction performed independently by at least 2 individuals. Search terms included: brain machine or computer interfaces, neurofeedback and motor; however, only studies requiring a motor attempt, versus motor imagery, were retained. Data extraction included participant characteristics, study design details and motor outcomes.

Results
From 5109 papers, 139 full texts were reviewed with 23 unique studies identified. All utilized EEG and, except for one, were on the stroke population. The most commonly reported functional outcomes were the Fugl-Meyer Assessment (FMA; n = 13) and the Action Research Arm Test (ARAT; n = 6) which were then utilized to assess effectiveness, evaluate design features, and correlate with training doses. Statistically and functionally significant pre-to post training changes were seen in FMA, but not ARAT. Results did not differ between robotic and electrical stimulation feedback paradigms. Notably, FMA outcomes were positively correlated with training dose.

Conclusion
This review on BCI-based neurofeedback training confirms previous findings of effectiveness in improving motor outcomes with some evidence of enhanced neuroplasticity in adults with stroke. Associative learning paradigms have emerged more recently which may be particularly feasible and effective methods for Neurorehabilitation. More clinical trials in pediatric and adult neurorehabilitation to refine methods and doses and to compare to other evidence-based training strategies are warranted.
A fatal case of viral sepsis and encephalitis in a child caused by human adenovirus type 7 infection
Authors: Zhao Hongwei , Liu Yingchao , Feng Ziheng , Feng Qianyu , Li Kechun , Gao Hengmiao , Qian Suyun , Xu Lili , Xie Zhengde 
Published: September 2022

AbstractAdenoviruses are highly prevalent pathogens responsible for a wide range of clinical diseases, including respiratory tract infection, acute gastroenteritis, and conjunctivitis. However, adenovirus infection is rarely associated with central nervous system involvement. Here, we report a fatal viral sepsis and encephalitis in a child caused by a human adenovirus type 7 infection. We detected human adenovirus type 7 in the patient’s nasopharyngeal swab, blood, and cerebrospinal fluid. Our findings indicate clinicians should be aware of the possible central nervous system involvement in adenovirus infection.
Early identification of bleeding in trauma patients: external validation of traumatic bleeding scores in the Swiss Trauma Registry
Authors: Costa Alan , Carron Pierre-Nicolas , Zingg Tobias , Roberts Ian , Ageron François-Xavier ,   for the Swiss Trauma Registry
Published: September 2022

Abstract
Background
Early identification of bleeding at the scene of an injury is important for triage and timely treatment of injured patients and transport to an appropriate facility. The aim of the study is to compare the performance of different bleeding scores.

Methods
We examined data from the Swiss Trauma Registry for the years 2015–2019. The Swiss Trauma Registry includes patients with major trauma (injury severity score (ISS) ≥ 16 and/or abbreviated injury scale (AIS) head ≥ 3) admitted to any level-one trauma centre in Switzerland. We evaluated ABC, TASH and Shock index (SI) scores, used to predict massive transfusion (MT) and the BATT score and used to predict death from bleeding. We evaluated the scores when used prehospital and in-hospital in terms of discrimination (C-Statistic) and calibration (calibration slope). The outcomes were early death within 24 h and the receipt of massive transfusion (≥ 10 Red Blood cells (RBC) units in the first 24 h or ≥ 3 RBC units in the first hour).

Results
We examined data from 13,222 major trauma patients. There were 1,533 (12%) deaths from any cause, 530 (4%) early deaths within 24 h, and 523 (4%) patients who received a MT (≥ 3 RBC within the first hour). In the prehospital setting, the BATT score had the highest discrimination for early death (C-statistic: 0.86, 95% CI 0.84–0.87) compared to the ABC score (0.63, 95% CI 0.60–0.65) and SI (0.53, 95% CI 0.50–0.56), P < 0.001. At hospital admission, the TASH score had the highest discrimination for MT (0.80, 95% CI 0.78–0.82). The positive likelihood ratio for early death were superior to 5 for BATT, ABC and TASH. The negative likelihood ratio for early death was below 0.1 only for the BATT score.

Conclusions
The BATT score accurately estimates the risk of early death with excellent performance, low undertriage, and can be used for prehospital treatment decision-making. Scores predicting MT presented a high undertriage rate. The outcome MT seems not appropriate to stratify the risk of life-threatening bleeding.
Trial registration: Clinicaltrials.gov, NCT04561050. Registered 15 September 2020.
Transcriptional signatures of the BCL2 family for individualized acute myeloid leukaemia treatment
Authors: Lee Chansub , Lee Sungyoung , Park Eunchae , Hong Junshik , Shin Dong-Yeop , Byun Ja Min , Yun Hongseok , Koh Youngil , Yoon Sung-Soo 
Published: September 2022

Abstract
Background
Although anti-apoptotic proteins of the B-cell lymphoma-2 (BCL2) family have been utilized as therapeutic targets in acute myeloid leukaemia (AML), their complicated regulatory networks make individualized therapy difficult. This study aimed to discover the transcriptional signatures of BCL2 family genes that reflect regulatory dynamics, which can guide individualized therapeutic strategies.

Methods
From three AML RNA-seq cohorts (BeatAML, LeuceGene, and TCGA; n = 451, 437, and 179, respectively), we constructed the BCL2 family signatures (BFSigs) by applying an innovative gene-set selection method reflecting biological knowledge followed by non-negative matrix factorization (NMF). To demonstrate the significance of the BFSigs, we conducted modelling to predict response to BCL2 family inhibitors, clustering, and functional enrichment analysis. Cross-platform validity of BFSigs was also confirmed using NanoString technology in a separate cohort of 47 patients.

Results
We established BFSigs labeled as the BCL2, MCL1/BCL2, and BFL1/MCL1 signatures that identify key anti-apoptotic proteins. Unsupervised clustering based on BFSig information consistently classified AML patients into three robust subtypes across different AML cohorts, implying the existence of biological entities revealed by the BFSig approach. Interestingly, each subtype has distinct enrichment patterns of major cancer pathways, including MAPK and mTORC1, which propose subtype-specific combination treatment with apoptosis modulating drugs. The BFSig-based classifier also predicted response to venetoclax with remarkable performance (area under the ROC curve, AUROC = 0.874), which was well-validated in an independent cohort (AUROC = 0.950). Lastly, we successfully confirmed the validity of BFSigs using NanoString technology.

Conclusions
This study proposes BFSigs as a biomarker for the effective selection of apoptosis targeting treatments and cancer pathways to co-target in AML.
Privacy-aware and Efficient Student Clustering for Sport Training with Hash in Cloud Environment
Authors: Diao Guoyan , Liu Fang , Zuo Zhikai , Moghimi Mohammad Kazem 
Published: September 2022

AbstractWith the wide adoption of health and sport concepts in human society, how to effectively analyze the personalized sports preferences of students based on past sports training records has become a crucial and emergent task with positive research significance. However, the past sports training records of students are often accumulated with time and stored in a central cloud platform and therefore, the data volume is too large to be processed with quick response. In addition, the past sports training records of students often contain certain sensitive information, which probably discloses partial user privacy if we cannot protect the data well. Considering these two challenges, a privacy-aware and efficient student clustering approach, named PESC is proposed, which is based on a hash technique and deployed on a central cloud platform connecting multiple local servers. Concretely, in the cloud platform, each student is firstly assigned an index based on the past sports training records stored in a local server, through a uniform hash mapping operation. Then similar students are clustered and registered in the cloud platform based on the students’ respective sport indexes. At last, we infer the personalized sport preferences of each student based on their belonged clusters. To prove the feasibility of PESC, we provide a case study and a set of experiments deployed on a time-aware dataset.
p53 amyloid aggregation in cancer: function, mechanism, and therapy
Authors: Li Jingzhi , Guo Ming , Chen Lin , Chen Zhuchu , Fu Ying , Chen Yongheng 
Published: September 2022

AbstractSimilar to neurodegenerative diseases, the concept that tumors are prion like diseases has been proposed in recent years. p53, the most well-known tumor suppressor, has been extensively studied for its expression, mutation, and function in various tumors. Currently, an interesting phenomenon of p53 prion-like aggregation has been found in several tumors, and studies have found that its pathological aggregation may lead to functional alterations and ultimately affect tumor progression. It has been demonstrated that the mechanism of p53 aggregation involves its mutation, domains, isoform, etc. In addition to p53 itself, some other factors, including Zn2+ concentration, pH, temperature and chaperone abnormalities, can also contribute to p53 aggregation. Although there are some studies about the mechanism and role of p53 aggregation and amyloidosis in tumors, there still exist some controversies. In this paper, we review the mechanism of p53 amyloid fibril structure and discuss the characteristics and effects of p53 amyloid aggregation, as well as the pathogenic mechanism leading to the occurrence of aggregation in tumors. Finally, we summarize the various inhibitors targeting p53 aggregation and prion-like behavior. In conclusion, a comprehensive understanding of p53 aggregation can expand our understanding of the causes leading its loss of physiological function and that targeting p53 aggregation might be a promising therapeutic strategy for tumor therapy.
Very small collars: an evaluation of telemetry location estimators for small mammals
Authors: Hummell Grace F. , Li Andrew Y. , Mullinax Jennifer M. 
Published: September 2022

AbstractBackgroundFine-scale tracking of animals such asPeromyscusspp. is still done with micro-very high frequency collars due to the animal’s small size and habitat usage. In most cases, tracking micro-very high frequency collars requires manual telemetry, yet throughout the literature, there is little reporting of individual telemetry methods or error reporting for small mammal spatial analyses. Unfortunately, there is even less documentation and consensus on the best programs used to calculate fine-scale animal locations from compass azimuths. In this study, we present a strategy for collecting fine-scale spatial data onPeromyscusspp.as a model species for micro-very high frequency collars and assess multiple programmatic options and issues when calculating telemetry locations.ResultsMice were trapped from April to October 2018–2019 with Sherman traps in Howard County, Maryland, USA. Collars were placed on 61 mice, of which 31 were included in the analyses. We compared the two most cited location estimator programs in the literature, location of a signal software and Locate III, as well as the Sigloc package in program R. To assess the programmatic estimates of coordinates at a fine scale and examine programmatic impacts on different analyses, we created and compared minimum convex polygon and kernel density estimator home ranges from locations produced by each program. We found that 95% minimum convex polygon home range size significantly differed across all programs. However, we found more similarities in estimates across calculations of core home ranges. Kernel density estimator home ranges had similar patterns as the minimum convex polygon home ranges with significant differences in home range size for 95% and 50% contours. These differences likely resulted from different inclusion requirements of bearings for each program.ConclusionsThis study highlights how different location estimator programs could change the results of a small mammal study and emphasizes the need to calculate telemetry error and meticulously document the specific inputs and settings of the location estimator.
Cultural exchange and integration: archaeometallurgical case study on underneath-blade bronze dagger-axes from Shuangyuan Village Site in the Eastern Zhou Dynasty
Authors: Li Yuexuan , Yang Yingdong , Wang Tianyou , Wang Xiaoting , Luo Wugan 
Published: September 2022

Abstract
As typical artifacts of the Ba-Shu culture, bronze dagger-axes have always been highly valued by academia. Underneath-blade bronze dagger-axes were utilized widely in both the Central Plains and southwest China. However, opinions differ on whether these underneath-blade bronze dagger-axes which excavated from Ba-Shu culture were produced locally. Combined with archaeological typology study, p-XRF and MC-ICP-MS were used to analyze 12 underneath-blade bronze dagger-axes unearthed from Shuangyuan Village Site, an Eastern Zhou cemetery in Chengdu city, Sichuan Province, Southwest China in order to investigate the cultural exchange and integration centered on the Shu culture. The composition results show that the majority of samples were made from copper, tin, and lead ternary alloy. The data on lead isotopes indicate that underneath-blade bronze dagger-axes have different mineral sources. The lead isotope ratio 206Pb/204Pb of 18.3 can draw the conclusion to be used as one of the bases for judging that underneath-blade bronze dagger-axes originated in the Chengdu Plain or the Central Plains which was consistent with the typology. The southern China lead materials of underneath-blade bronze dagger-axes in the Ba-Shu and Central Plains style probably came from southern Sichuan; while the rest of underneath-blade bronze dagger-axes in the Central Plains style might use lead materials in the western Hunan-western Hubei area. The Shu culture which was represented by Shuangyuan Village Site in Chengdu Plain during the Eastern Zhou Dynasty had close cultural communication with the Central Plains and Chu cultures. This study reveals that Ba-Shu had a direct exchange of minerals or metal products with the Central Plains and Chu, as well as an imitation based on the identification of the foreign culture and the belief in the local Shu cultural traditions.
Multiple systemic artery to pulmonary vessel fistulas (SAPVFs) completely resected by video-assisted thoracoscopic surgery: a case report
Authors: Matsudo Kyoto , Haratake Naoki , Ono Yuki , Kohno Mikihiro , Takenaka Tomoyoshi , Yoshizumi Tomoharu 
Published: September 2022

Abstract
Background
Systemic artery to pulmonary vessel fistula (SAPVF) is an uncommon abnormal vascular communication between systemic arteries and the lung parenchyma. It has been reported that the appropriate treatment for SAPVF is embolization or surgical resection. However, in patients such as ours, who have many aberrant vessels or multiple lesions, surgery should be considered as the first-choice treatment.

Case presentation
This case report describes multiple SAPVFs and huge bullae at the apex of the left lung in a 43-year-old man that were resected completely with the video-assisted thoracoscopic surgery (VATS). The patient had an uneventful postoperative recovery without any complications and was discharged 9 days postoperatively. He had heavy smoking history, and the giant bullae and the diffuse emphysematous change were found in the lung. Therefore, the chronic inflammation may have been present in the thoracic cavity, which caused multiple SAPVFs.

Conclusions
We describe the clinical course and management of the patient with multiple SAPVFs who had no obvious history of surgery, trauma, or various inflammatory or infection diseases. VATS should be the first-choice treatment in patients with many abnormal vessels or multiple lesions.
Fund behavioral science like the frameworks we endorse: the case for increased funding of preliminary studies by the National Institutes of Health
Authors: Beets Michael W. , Pfledderer Christopher , von Klinggraeff Lauren , Burkart Sarah , Armstrong Bridget 
Published: September 2022

AbstractInnovative, groundbreaking science relies upon preliminary studies (aka pilot, feasibility, proof-of-concept). In the behavioral sciences, almost every large-scale intervention is supported by a series of one or more rigorously conducted preliminary studies. The importance of preliminary studies was established by the National Institutes of Health (NIH) in 2014/2015 in two translational science frameworks (NIH Stage and ORBIT models). These frameworks outline the essential role preliminary studies play in developing the next generation of evidence-based behavioral prevention and treatment interventions. Data produced from preliminary studies are essential to secure funding from the NIH’s most widely used grant mechanism for large-scale clinical trials, namely the R01. Yet, despite their unquestionable importance, the resources available for behavioral scientists to conduct rigorous preliminary studies are limited. In this commentary, we discuss ways the existing funding structure at the NIH, despite its clear reliance upon high-quality preliminary studies, inadvertently discourages and disincentivizes their pursuit by systematically underfunding them. We outline how multiple complementary and pragmatic steps via a small reinvestment of funds from larger trials could result in a large increase in funding for smaller preliminary studies. We make the case such a reinvestment has the potential to increase innovative science, increase the number of investigators currently funded, and would yield lasting benefits for behavioral science and scientists alike.
Employment-related musculoskeletal complications experienced by the physical therapists in Bangladesh: a comprehensive cross-sectional case study
Authors: Hossain Amran , Proma Tasnuva Shamarukh , Raju Rashaduzzaman , Ahmed Sharmin , Islam Ariful 
Published: September 2022

Abstract
Background
Dentists, nurses, and physical therapists have all been associated with an increased risk of work-related diseases. The findings of studies in these different occupations might aid in the development of preventative measures. In Bangladesh, however, no comparable evidence has been recorded among physical therapists. The study’s goal was to find out the prevalence of work-related physical problems at different anatomical locations, as well as the link between these disorders and treatment strategies across Bangladeshi physical therapists.

Methods
A physical and online survey of Bangladeshi physical therapists was done. A total of 300 questionnaires were given out, with work-related discomfort or pain detected in nine locations of the body: (1) neck, (2) shoulder, (3) elbow, (4) wrists, (5) upper back, (6) lumbar, (7) thighs, (8) knee, and (9) ankle.

Results
85.5% of Bangladeshi physical therapists suffer musculoskeletal problems, according to the results of this research. The neck (25.7%), lower back (15.2%), elbow (12.3%), ankle (8.6%), and shoulder (8.6%) were the most often affected locations (7.1%). Upper back (3.0%) and hips (2.2%) ailments had the lowest prevalence.

Conclusion
Work-related musculoskeletal illnesses were common among the Bangladeshi physical therapists, especially in their neck, lower back, elbow, and ankle regions.