bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation and Evaluation of Letrozole Nanosuspension By Probe
Sonication Method using Box-behnken Design
Authors: Sailaja Abbaraju Krishna , Alekhya Amand 
Published: August 2022

Background:
Letrozole (LTZ), is an aromatase inhibitor used for the treatment of hormonally positive breast cancer in postmenopausal women. Letrozole is categorized as a BCS class I drug. It has poor water solubility, rapid metabolism and a range of side effects.

Objective:
Nanosuspension is a technique which enhances the drug's solubility and bioavailability, resulting in a faster start of effect. The present study was aimed, to formulate nanosuspension using probe sonication method for the enhancement of solubility of Letrozole using poloxamer-188 as stabilizer. The formulation scheme was generated by using Box-Behnken design which is a statistical tool of design of experiments (DOE).

Results:
Total seventeen formulations were performed for letrozole nanosuspension as suggested by Box-Behnken design by employing probe sonication method. The selected formulations are characterized for particle size and zeta potential. The formulations were checked on percentage of bias in between predicted value and observed value and evaluated for drug content and invitro dissolution study. The formulation was optimized using Box-Behnken design based on invitro cumulative drug release. Among all the formulations NS4 (500mg poloxamer-188, 100mg Letrozole and sonication time of 20mints) was considered to be best with minimum Particle size of 923.5nm, Zeta potential value of -28.7mV, 96.36% of drug content and 94.02% of drug release within 2 hours. Solubility was determined by shake flask method. The solubility of pure drug was found to be only 10%. The solubility studies were performed for the optimized formulation of NS4 showed that the solubility has enhanced up to 90% when compared to pure drug.

Conclusion:
Thus, the present results revealed that Letrozole nanosuspension solubility has enhanced up to 90% when compared to pure drug by using poloxamer-188 as stabilizer.
Web-Based System Navigation Database to Support Equitable Access to Assistive Technology: Usability Testing Study
Authors: Jarvis Tamika , Mah Allison M L , Wang Rosalie H , Wilson Michael G 
Published: August 2022

Background
Assistive technology (AT) can contribute to how individuals participate and engage in everyday activities, such as communication and mobility, and facilitates access to the services they require. Navigating Canada’s AT system has been described as fragmented and complex, presenting barriers for individuals who require AT, caregivers, and health service providers. AccessATCanada was developed as a centralized web-based resource to help support access to AT by providing information about the existing jurisdictional funding programs and services.

Objective
This study aimed to evaluate the usability of AccessATCanada by gathering feedback about its features, functionality, and areas of strength and opportunity from potential end users.

Methods
A usability testing study using a think-aloud approach and semistructured interviews was conducted to measure the effectiveness and efficiency of and user satisfaction with AccessATCanada and to identify issues with the interface during end-user interaction. A qualitative thematic analysis was used to generate insights into and core themes about user experiences. User feedback was used to inform subsequent updates of the database with the goal of enhancing website friendliness and functionality before its official launch.

Results
A total of 10 participants (6 consumers, 1 caregiver, and 3 providers) participated in the usability testing study. The usability performance and scores tended to improve between the 2 testing cycles. Most participants were able to successfully complete all the tasks independently. The efficiency scores tended to improve as the users continued to engage with the interface. The website received an overall System Usability Score of 62.22, which was ranked as “OK/fair to good.” The users provided an overall positive evaluation of the beta version of the web-based resource tested over 2 cycles and helped to identify areas for improvement. They commented on the functionality and added value of the website, discovery of new programs and resources, and design aesthetics. Most usability issues were reported as minor challenges related to presentation, functionality, and language, and feedback was adopted into later iterations of the website.

Conclusions
This study provides reflections on the value of usability testing and elements that are key to the creation of user-centered resources, such as the inclusion of participants with various abilities and considerations regarding website design and accessibility in an increasingly web-based world. AccessATCanada is now part of a growing global response to expand the reach of AT programs and services, improve the equity of access to AT, and reduce the complexity of navigating AT systems.
Oral Health Coaches at Well-Baby Clinics to Promote Oral Health in Preschool Children From the First Erupted Tooth: Protocol for a Multisite, Pragmatic Randomized Controlled Trial
Authors: van Spreuwel Peggy C J M , Jerković-Ćosić Katarina , van Loveren Cor , van der Heijden Geert J M G 
Published: August 2022

Background
Early childhood caries is considered one of the most prevalent diseases in childhood, affecting almost half of preschool-age children globally. In the Netherlands, approximately one-third of children aged 5 years already have dental caries, and dental care providers experience problems reaching out to these children.

Objective
Within the proposed trial, we aim to test the hypothesis that, compared to children who receive usual care, children who receive the Toddler Oral Health Intervention as add-on care will have a reduced cumulative caries incidence and caries incidence density at the age of 48 months.

Methods
This pragmatic, 2-arm, individually randomized controlled trial is being conducted in the Netherlands and has been approved by the Medical Ethics Research Board of University Medical Center Utrecht. Parents with children aged 6 to 12 months attending 1 of the 9 selected well-baby clinics are invited to participate. Only healthy children (ie, not requiring any form of specialized health care) with parents that have sufficient command of the Dutch language and have no plans to move outside the well-baby clinic region are eligible. Both groups receive conventional oral health education in well-baby clinics during regular well-baby clinic visits between the ages of 6 to 48 months. After concealed random allocation of interventions, the intervention group also receives the Toddler Oral Health Intervention from an oral health coach. The Toddler Oral Health Intervention combines behavioral interventions of proven effectiveness in caries prevention. Data are collected at baseline, at 24 months, and at 48 months. The primary study endpoint is cumulative caries incidence for children aged 48 months, and will be analyzed according to the intention-to-treat principle. For children aged 48 months, the balance between costs and effects of the Toddler Oral Health Intervention will be evaluated, and for children aged 24 months, the effects of the Toddler Oral Health Intervention on behavioral determinants, alongside cumulative caries incidence, will be compared.

Results
The first parent-child dyads were enrolled in June 2017, and recruitment was finished in June 2019. We enrolled 402 parent-child dyads.

Conclusions
All follow-up interventions and data collection will be completed by the end of 2022, and the trial results are expected soon thereafter. Results will be shared at international conferences and via peer-reviewed publication.

Trial Registration
Netherlands Trial Register NL8737; https://trialsearch.who.int/Trial2.aspx?TrialID=NL8737

International Registered Report Identifier (IRRID)
DERR1-10.2196/39683
Pendekatan Blended Learning Model Class Demonstration untuk Mengatasi Kesulitan Belajar dan Meningkatkan Prestasi Belajar Fungsi Kuadrat dan Fungsi Komposisi
Authors: Nugroho Wachid 
Published: August 2022

AbstrakPembelajaran jarak jauh secara daring dari rumah mengalami berbagai hambatan dan kesulitan belajar yang dirasakan oleh peserta didik. Beberapa penelitian dan kajian pendahuluan menguatkan temuan berbagai kesulitan belajar siswa selama PJJ daring dan memerlukan solusi permasalahan. Penelitian ini bertujuan untuk mendeskripsikan pendekatan blended learning model class demonstration agar dapat mengatasi kesulitan pembelajaran daring serta meningkatkan prestasi belajar siswa khususnya materi fungsi kuadrat dan fungsi komposisi di akhir semester gasal 2021-2022. Metode penelitian menggunakan penelitian tindakan kelas dua siklus pada 36 siswa kelas XI di salah satu Sekolah Kejuruan Kota Salatiga. Hasil penelitian menunjukkan bahwa rata-rata siswa yang dapat mengatasi kesulitan belajar pra-siklus sebesar 63,33%, sedangkan setelah adanya tindakan meningkat sebesar 17% menjadi 80,33%. Capaian kenaikan prestasi belajar siswa dapat dilihat dari perolehan rata-rata nilai pra-siklus sebesar 66,94 meningkat menjadi 76,39 pada siklus I dan meningkat lagi menjadi 85,00 pada siklus II. Sedangkan ketuntasan kelas pra-siklus sebesar 49,07% meningkat menjadi 58,33% pada siklus I dan meningkat lagi menjadi 72,22% pada siklus II. AbstractOnline distance learning from home experiences various obstacles and learning difficulties feld by students. Several research and preliminary studies corroborate the findings of various student learning difficulties during online PJJ and require problem solutions. This research aims to describe the blended learning approach with class demonstration model in order to overcome online learning difficulties and improve student learning achievement, especially the material of quadratic functions and composition functions at the end of the odd semester 2021-2022. The research method uses classroom action research with two cycles on 36 students off XI class at one of vocational schools in Salatiga City. The results showed that the average number of students who could overcome pre-cycle learning difficulties was 63,33%, while after the action it increased by 17% to 80,33%. The rate of student achievement can be seen from the average pre-cycle score of 66,94 which increased to 76,39 in the first cycle and increased again to 85,00 in the second cycle. While the pre-cycle class completeness was 49,07% increased to 58,33% in the first cycle and increased again to 72,22% in the second cycle.
Factors that Influence Entrepreneurship Decision Making in Shaping the Characteristics Entrepreneurial of MSMEs among Women in Makassar City
Authors: Nurjanna  , Tawe Amiruddin , Sahabuddin Romansyah , Putera Wahyudi , Yahya Indah Lestari 
Published: August 2022

This study aims to test and find out how the influence between relationships of personality factors and contextual element to entrepreneurship decision making through characteristics entrepreneurial. This type of research is a quantitative-qualitative approach (Mixed Methode). The population in the study was the overall micro small and medium enterprises MSMEs which amounted to 8,756 people / businesses. The sample used in this study using probability sampling was obtained by a sample of 382 respondents / businesses while informants amounted to 3 people who were determined using technical purposive sampling that had the capacity as a key informant in accordance with the criteria.The analytical technique used in hypothesis testing is to use SEM (Structural Equation Modeling) analysis with the help of the AMOS Ver,- program,-. The results of quantitative research and transcripts of the interview process conducted at qualitative stages analyzed descriptively showed that the influence of indirectly personality factors had a significant effect on characteristics entrepreneurial, contextual element had a significant effect on entrepreneurial characteristics. The direct influence of personality factors has a significant effecat on entrepreneurship decisions, contextual element has a significant effect on entrepreneurship decisions and characteristics entrepreneurial have a significant effect on entrepreneurship decisions.
Bottleneck and development path of water resources protection and utilization in Henan Province in the new era
Authors: Zhang Weiqiang , Du Jinghua , Wang Yanxiao , Li Junyu , Feng Peng , Sun Hao , Qiao Guodong , Sun Xiaolin , Li Sen 
Published: August 2022

Objective：to promote the sustainable and efficient utilization of water resources in Henan Province, accelerate the optimization of the water resources management system, innovate the government administrative management mode, and provide new strategic countermeasures and path choices for the industrial upgrading and transformation in water resources related fields and the high-quality development of regional economy in Henan Province. Methods: by combing the current situation and existing problems of water resources utilization in Henan Province, this study focuses on analyzing the strategic opportunities faced by the field of water resources in Henan Province and expounds on the innovation and application of cutting-edge key technologies for water resources protection and utilization in Henan Province. Results: while the protection and utilization of water resources in Henan Province have achieved great results, it still faces great challenges: low water-saving results, imperfect advanced technology system, unstable water pollution control results, and imperfect water resource management mechanism. Conclusion: in the future, we must coordinate the relationship between water resources development and protection, establish the idea of harmonious development, give full play to the regional advantages of Henan Province, strengthen the research and development of cutting-edge key technologies, innovate the government management mechanism, and realize the efficient and sustainable utilization of water resources.
HUBUNGAN STRES DENGAN KEJADIAN TIMBULNYA ACNE VULGARIS PADA SISWA DI SMP NEGERI 2 KOTA BANDA ACEH
Authors: Firnanda Ryan , Masthura Syarifah , Mulyatina Mulyatina 
Published: August 2022

Stress can not only affect a person’s psyche but can also affect in term of pathophysiology. Stress causes one of the skin disease that are often a problem for adolescents and adults, namely acne vulgaris. This study aims to determine the relationship of stress with the incidence of acne vulgaris. This study used a correlational descriptive by incorporating the cross-sectional design. The total sample was 81 respondents. The measuring instrument used is a questionnaire and GAGS (Global Acne Grading System) observation sheet. Validity test using the item-total correlation, the results of the validity value r > 0,444 and declared valid. The reliability test obtained the results of the cronbach alpha value of 0,60, so it can be concluded that the instrument is declared reliable. Bivariate test showed that there was correlation between stress and the incidence of acne vulgaris among students in SMP Negeri 2 Banda Aceh 2019 with p-value = 0,001. Moderate acne vulgaris mostly occurs in students who experience stress, while mild acne vulgaris occurs in students who do not experience stress.
PERILAKU CARING PERAWAT DI RUANG ISOLASI COVID-19 RSUP SANGLAH DENPASAR: SEBUAH STUDI MIXED METHODS
Authors: Lisnawati Luh Gede , Pande Rai Dewi Damayanthi , Yudari Ni Made Adi 
Published: August 2022

Caring adalah inti dari profesi keperawatan yang dibutuhkan dalam pelayanan keperawatan. Penerapan nilai-nilai caring dalam pelayanan keperawatan menjadi tantangan tersendiri di saat terjadinya pandemi COVID-19. Penelitian ini bertujuan mendapatkan gambaran perilaku caring perawat, hubungan faktor individu perawat dengan perilaku caring dan mengeksplorasi secara mendalam mengenai implementasi caring di Ruang Isolasi COVID-19. Penelitian menggunakan desain sequential explanatory mixed methods dimana penelitian kuantitatif dilakukan menggunakan instrumen kuesioner kepada subjek penelitian yang dipilih menggunakan total sampling. Sementara itu, penelitian kualitatif dilakukan dengan wawancara mendalam terhadap 6 partisipan yang dipilih dari masing-masing 2 orang dari perawat dengan perilaku caring kurang baik dan baik ditambah 2 orang penanggung jawab ruang dari ruang dengan nilai caring baik tertinggi dan ruang dengan perilaku caring baik terendah. Hasil penelitian mendapatkan bahwa tingkat caring perawat diketahui baik yakni 93 orang (80,2%). Hasil uji chi square test menunjukkan terdapat hubungan yang signifikan antara ruangan bekerja atau tempat bertugas terhadap perilaku caring perawat (p=0,033, ?<0,05). Akan tetapi, tidak terdapat hubungan antara usia (p=0,539), jenis kelamin (p=0,931), tingkat pendidikan (p=0,474), lama bekerja di RSUP Sanglah Denpasar (p=0,430), lama bekerja di ruangan isolasi COVID-19 (p=0,456), dan pelatihan isolasi dan infeksi (p=0,083) terhadap perilaku caring perawat. Hasil wawancara mengenai implementasi caring perawat mendapatkan beberapa tema yang berhasil diidentifikasi seperti pengalaman, perasaan positif dan negatif, gambaran pelaksanaan caring, pemahaman caring dan faktor demografi yang mempengaruhi.
GAMBARAN AKTIVITAS FISIK PASIEN DIABETES MELLITUS DI MASA PANDEMI COVID-19
Authors: Isnarawati Zakianor , Diani Noor , Agianto Agianto 
Published: August 2022

Diabetes mellitus is one of the main risk factors for susceptibility to Covid-19 infection with uncontrolled blood sugar levels. In patients with diabetes mellitus, physical activity is one of the pillars of diabetes mellitus management which functions to improve insulin sensitivity and also maintain body fitness. The purpose of this study was to describe the level of physical activity of patients with diabetes mellitus during the Covid-19 pandemic in Banjarmasin. The research design used a quantitative descriptive research with non-probability sampling technique with a total sampling type involving 44 diabetes mellitus patients as respondents. Using the Physical Activity Questionnaires (IPAQ) questionnaire instrument. Data analysis using descriptive analysis with results that show a description of the physical activity of diabetes mellitus patients in the Covid-19 pandemic in Banjarmasin from 44 respondents 10 respondents (22,7%) low physical activity, 17 respondents (36,6%) moderate physical activity, and 17 respondents (36,6%) had strenuous physical activity. Physical activity of patients with diabetes mellitus in the Covid-19 pandemic has shown an increase. The expected physical activity in the patient is in accordance with the recommendations, namely the patient with diabetes mellitus is active with physical activity with a moderate to severe level of physical activity according to the ability and condition of the patient, both activities carried out related to work, transportation, domestic activities, activities on time relaxed, and sitting time at least 10 minutes in one activity in the span of the last week.
HUBUNGAN PERSEPSI PEMBELAJARAN DARING TERHADAP TINGKAT PROKRASTINASI MAHASISWA
Authors: Salsabilla Zahwa Ayunda , Bayhakki Bayhakki , Woferst Rismadefi 
Published: August 2022

Perception is a stage of work by one of the five senses so that an understanding is obtained. Increasing the role and activity of students for the success of online lectures is strongly influenced by perceptions. This perception will later shape students to be able to carry out online lecture activities well and enthusiastically, including one of them in self-regulation, managing or managing time. Students' perceptions of online learning are related to their behavior, one of which is doing academic procrastination behavior (procrastination behavior).This study aims to determine the correlation between students' perceptions of online learning and students' procrastination level in Nursing students at Riau University. This study used a descriptive correlational design with a cross-sectional approach. The research sample was 242 respondents using a simple random sampling technique. The analysis used univariate analysis to see the frequency distribution and bivariate analysis using the chi-square test. The measuring instrument used is an online learning perception questionnaire consisting of 12 statements that have been tested for validity with r count 0,461 - 0,745 > r table (0,444), and the academic procrastination questionnaire contains 16 statements that also have been tested for validity with r count 0,445 - 0,645 > r table (0,444). The questionnaires were distributed via a google form. The results showed that the majority of students had a positive perception of online learning (51,7%) and high academic procrastination behavior (56,2%). The results of the chi-square test show that there is a correlation between the perception of online learning and students' procrastination with a p-value (0,000) < alpha (0,05). Academic procrastination in the Faculty of Nursing, University of Riau is in the high category. Students are expected to be more active and enthusiastic in participating in online lectures and increase understanding related to online learning so that they can operate and follow the online learning process comfortably and adequately to reduce academic procrastination behavior due to poor perceptions of online learning.
Dubbing Translation Technique in the Animated Film of Frozen: Party is Over
Authors: Astuti Purwani Indri , Widarwati Nunun Tri , Wijayava Ratih , Muamaroh Muamaroh 
Published: August 2022

Background:
Dubbing is an interesting translation for movie viewers because viewers do not need to be constrained by reading the subtitling on the monitor. However, with all its limitations dubbing is a challenge for a translator. Frozen: Party is over is an intriguing film to investigate.
Methodology:
All utterances of the characters in the film are becoming the research data. The numbers of data were 62 for words, phrases and sentences and analyzed using Molina & Albir's translation theory. The interactive model of Miles and Huberman analyzed all the data.
Findings:
The result of the research is that the translation techniques used by the translator were modulation, established equivalent and literal. The most dominant technique used by the translator was literal. This is because children consume the film, so most of the sentences are simple sentences.
Conclusion:
The translation techniques used by the translator were modulation, established equivalent and literal.
Originality:
This research focused on the dubbing translation technique for the animated film Frozen: Party is over. In comparison, other research with the same object discussed topics such as deixis, language styles, illocutionary act and subtitling.