bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do patients with fibromyalgia have body image and tactile acuity distortion?
Authors: Menten Laura A. , Franco Katherinne F. M. , Franco Yuri R. S. , Miyamoto Gisela C. , Reis Felipe J. J. , Cabral Cristina M. N. 
Published: August 2022

AbstractBackgroundThe aims of this study were twofold: (1) to compare the body image and tactile acuity of patients with fibromyalgia and asymptomatic participants, and (2) to investigate the effects of an 8‐week exercise‐based intervention (aerobic or Pilates exercises) on the body image, tactile acuity, and pain intensity in patients with fibromyalgia.MethodsA cross‐sectional study and a secondary analysis of a randomized controlled trial were carried out, which assessed the following outcomes in 24 patients with fibromyalgia and 24 asymptomatic participants: subjective body image (Drawing Test), tactile acuity (Two‐Point Discrimination Test), limb circumference (Cirtometry), and pain (Pain Numerical Rating Scale). After the assessment, the 24 patients with fibromyalgia were randomly allocated to one of the intervention groups: aerobic or Pilates.ResultsThere was no significant difference in the tactile acuity of the cervical, lumbar, hands, and feet regions between the participants with fibromyalgia and the asymptomatic participants (p > 0.05). However, patients with fibromyalgia showed changes in subjective body image when the drawings were compared to the cirtometry measurements. After the intervention, there was no significant difference between aerobic exercise and Pilates for pain and tactile acuity in the cervical, lumbar, hands, and feet regions of patients with fibromyalgia (p > 0.05).ConclusionsPatients with fibromyalgia presented altered perception in subjective body image but not on tactile acuity, when compared to asymptomatic participants. In addition, there was no difference between aerobic exercise and Pilates for pain and tactile acuity in these patients.
“They may be confronting but they are good questions to be asking” young people's experiences of completing a trauma and PTSD screening tool in an early psychosis program
Authors: Dryden‐Mead Tracey , Nelson Barnaby , Bendall Sarah 
Published: August 2022

AbstractBackgroundThere is a history of inadequate enquiry about, and assessment of, trauma in young people within Early Psychosis services and even when screening does occur there is little known about how young people experience this process.AimsThis study aimed to explore young people's experiences of completing a trauma and PTSD screening tool when receiving a service in an Early Psychosis Program.MethodSemi‐structured interviews were conducted with 10 young people, aged 18–24 years, to explore their subjective experience of this process. Transcripts were analysed via interpretative phenomenological analysis.ResultsFour super‐ordinate themes were identified: (i) an emotional experience, (ii) the importance of the relationship with the clinician, (iii) an opportunity to reflect on past experiences, and (iv) the ability to be able to provide honest responses. Results from this study indicated that young people expected to be asked about their trauma experiences, acknowledged that this was challenging for them but found that this was made easier due to the relationship they had built with the clinician, the timing of the screening and also, possibly, by the written style format of the questionnaires.ConclusionsYoung people in this study accepted the need for screening for traumatic histories, and expected to be asked about their traumatic experiences, despite the possibility of a short‐term increase in distress. The support offered by a trusted clinician, whom the young person had built a relationship with, appeared to be an important component to the willingness and the ability of the young person to complete the questionnaires. This reinforces the fact that screening for trauma in an early psychosis service can be conducted in a way that is safe and acceptable to young people.
Nurse practitioner in Swedish municipal elderly care: A Delphi study of challenges and opportunities
Authors: Ljungbeck Birgitta , Sjögren‐Forss Katarina , Carlson Elisabeth 
Published: August 2022

AbstractIntroductionWorldwide, countries are struggling with strained healthcare systems, especially due to the growing number of frail elderly. Developing the role of nurse practitioner in the care of the frail elderly is therefore of interest to make the care chain more efficient. In Sweden, the role is in an early development phase, but more research is needed.AimThe aim was to investigate how stakeholders at the national level express the challenges and opportunities of the evolving nurse practitioner role in Swedish municipal elderly care.MethodA Delphi survey technique with three rounds of electronic questionnaires was used. Twenty‐seven experts responded to the first questionnaire, containing two open questions; what opportunities respectively challenges do you see in developing and implementing the nurse practitioner role in municipal elderly care? The following questionnaires consisted of statements to rate using a four‐grade Likert scale, and 20 and 17 responded to the second and third, respectively. The first round was analysed using content analysis, and the other two with descriptive statistics.ResultsThirty‐four statements about challenges and opportunities related to the nurse practitioner role in municipal elderly care were identified and rated as important.ConclusionThe findings provide knowledge that can contribute to discussions and decisions to refine the nurse practitioner role in Swedish municipal elderly care. The nurse practitioner role may contribute with much‐needed competence to the elderly care. However, it is important to consider the challenges that need to be overcome before the development of the role. To solve this, it is necessary to have clear national guidelines concerning issues of education, title protection and the mandate and authority of the NP role.
Agree as information transmission over dependencies
Authors: Ermolaeva Marina , Kobele Gregory M. 
Published: August 2022

AbstractIn contemporary Minimalism agreement is the result of a syntactic operation. In contrast to Merge, Agree does not build structure, its role being to transmit morphological features from one head to another. We provide an alternative perspective on agreement in a Minimalist idiom, one that cuts the ontological pie in a different way. Syntax has as its only operation Merge, and agreement, now divorced from syntax, transfers purely morphological information from head to head alongchannelsestablished via syntactic feature checking. Separating agreement from structure building seems to enable more elegant descriptions of even complicated agreement phenomena.
Comparative transcriptome and metabolome analyses identified the mode of sucrose degradation as a metabolic marker for early vegetative propagation in bulbs of Lycoris
Authors: Ren Zi‐Ming , Zhang Dong , Jiao Chen , Li Dan‐Qing , Wu Yun , Wang Xiu‐Yun , Gao Cong , Lin Ye‐Fan , Ruan Yong‐Ling , Xia Yi‐Ping 
Published: August 2022

SUMMARYVegetative propagation (VP) is an important practice for production in many horticultural plants. Sugar supply constitutes the basis of VP in bulb flowers, but the underlying molecular basis remains elusive. By performing a combined sequencing technologies coupled with ultra‐high performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry approach for metabolic analyses, we compared two Lycoris species with contrasting regeneration rates: high‐regeneration Lycoris sprengeri and low‐regeneration Lycoris aurea. A comprehensive multi‐omics analyses identified both expected processes involving carbohydrate metabolism and transcription factor networks, as well as the metabolic characteristics for each developmental stage. A higher abundance of the differentially expressed genes including those encoding ethylene responsive factors was detected at bulblet initiation stage compared to the late stage of bulblet development. High hexose‐to‐sucrose ratio correlated to bulblet formation across all the species examined, indicating its role in the VP process in Lycoris bulb. Importantly, a clear difference between cell wall invertase (CWIN)‐catalyzed sucrose unloading in high‐regeneration species and the sucrose synthase‐catalyzed pathway in low‐regeneration species was observed at the bulblet initiation stage, which was supported by findings from carboxyfluorescein tracing and quantitative real‐time PCR analyses. Collectively, the findings indicate a sugar‐mediated model of the regulation of VP in which high CWIN expression or activity may promote bulblet initiation via enhancing apoplasmic unloading of sucrose or sugar signals, whereas the subsequent high ratio of hexose‐to‐sucrose likely supports cell division characterized in the next phase of bulblet formation.
Novel identification and modulation of the mechanosensitive Piezo1 channel in human myometrium
Authors: Barnett Scott D. , Asif Hazik , Buxton Iain L. O. 
Published: August 2022

AbstractApproximately 10% of US births deliver preterm before 37 weeks of completed gestation. Premature infants are at risk for life‐long debilitating morbidities and death, and spontaneous preterm labour explains 50% of preterm births. In all cases existing treatments are ineffective, and none are FDA approved. The mechanisms that initiate preterm labour are not well understood but may result from dysfunctional regulation of quiescence mechanisms. Human pregnancy is accompanied by large increases in blood flow, and the uterus must enlarge by orders of magnitude to accommodate the growing fetus. This mechanical strain suggests that stretch‐activated channels may constitute a mechanism to explain gestational quiescence. Here we identify for the first time that Piezo1, a mechanosensitive cation channel, is present in the uterine smooth muscle and microvascular endothelium of pregnant myometrium. Piezo is downregulated during preterm labour, and stimulation of myometrial Piezo1 in an organ bath with the agonist Yoda1 relaxes the tissue in a dose‐dependent fashion. Further, stimulation of Piezo1 while inhibiting protein kinase A, AKT, or endothelial nitric oxide synthase mutes the negative inotropic effects of Piezo1 activation, intimating that actions on the myocyte and endothelial nitric oxide signalling contribute to Piezo1‐mediated contractile dynamics. Taken together, these data highlight the importance of stretch‐activated channels in pregnancy maintenance and parturition, and identify Piezo1 as a tocolytic target of interest.imageKey pointsSpontaneous preterm labour is a serious obstetric dilemma without a known cause or effective treatments.Piezo1 is a stretch‐activated channel important to muscle contractile dynamics.Piezo1 is present in the myometrium and is dysregulated in women who experience preterm labour.Activation of Piezo1 by the agonist Yoda1 relaxes the myometrium in a dose‐dependent fashion, indicating that Piezo1 modulation may have therapeutic benefits to treat preterm labour.
Classification of Layout vs. Relational Tables on the Web: Machine Learning with Rendered Pages
Authors: Haider Waqar , Yesilada Yeliz 
Published: August 2022

Table mining on the web is an open problem, and none of the previously proposed techniques provides a complete solution. Most research focuses on the structure of the HTML document, but because of the nature and structure of the web, it is still a challenging problem to detect relational tables. Web Content Accessibility Guidelines (WCAG) also cover a wide range of recommendations for making tables accessible, but our previous work shows that these recommendations are also not followed; therefore, tables are still inaccessible to disabled people and automated processing. We propose a new approach to table mining by not looking at the HTML structure, but rather, the rendered pages by the browser. The first task in table mining on the web is to classify relational vs. layout tables, and here, we propose two alternative approaches for that task. We first introduce our dataset, which includes 725 web pages with 9,957 extracted tables. Our first approach extracts features from a page after being rendered by the browser, then applies several machine learning algorithms in classifying the layout vs. relational tables. The best result is with Random Forest with the accuracy of 97.2% (F1-score: 0.955) with 10-fold cross-validation. Our second approach classifies tables using images taken from the same sources using Convolutional Neural Network (CNN), which gives an accuracy of 95% (F1-score: 0.95). Our work here shows that the web’s true essence comes after it goes through a browser and using the rendered pages and tables, the classification is more accurate compared to literature and paves the way in making the tables more accessible.
Effectiveness of Resistance Training on Fatigue in Patients Undergoing Cancer Treatment: A Meta-Analysis of Randomized Clinical Trials
Authors: Berríos-Contreras Lily , Cuevas-Cid Rodrigo , Lorca Luz Alejandra , Ribeiro Ivana Leão 
Published: August 2022

Objective. To assess the effectiveness of the resistance training to improve fatigue levels in people with cancer who are enrolled in adjuvant and/or neoadjuvant treatment. Methods. MEDLINE, Web of Science, Embase, SPORTDiscus, LILACS, CENTRAL, and CINAHL databases were searched from May to December 7, 2021. Randomized clinical trials (RCT) that evaluate the effects of resistance training on fatigue levels in people undergoing cancer treatment were included. The PEDro scale was considered to assess methodological quality of studies, and the evidence was summarized through the GRADE system. The standardized average differences, effect size, and inverse variance model for meta-analysis were calculated. Results. Fifteen RCT for qualitative synthesis and thirteen for meta-analysis were selected. A moderate to high level of evidence of resistance training was identified to improve fatigue in people undergoing cancer treatment. Meta-analysis showed a significant reduction in fatigue (

SMD
=
−
0.31

,

CI

95
%
=
−
0.58

, -0.12,

P
=
0.001

) after 10 to 35 sessions of resistance training. Conclusion. The 10 to 35 sessions of resistance training are effective in reducing fatigue level in cancer patients who are undergoing cancer treatment and have a moderate level of quality evidence.
Ribonuclease H2 Subunit A Preserves Genomic Integrity and Promotes Prostate Cancer Progression
Authors: Kimura Naoki , Takayama Ken-ichi , Yamada Yuta , Kume Haruki , Fujimura Tetsuya , Inoue Satoshi 
Published: August 2022

Homeostasis of genomic integrity should be regulated to promote proliferation and inhibit DNA damage–induced cell death in cancer. Ribonuclease H2 (RNase H2) maintains genome stability by controlling DNA:RNA hybrid and R-loop levels. Here, we identified that RNase H2 subunit A (RNASEH2A), a component of RNase H2, is highly expressed in castration-resistant prostate cancer (CRPC) tissues compared with localized prostate cancer. Interestingly, we showed that RNASEH2A suppressed R-loop levels to prevent cell apoptosis induced by DNA damage in prostate cancer cells. Both in vivo and in vitro studies revealed that RNASEH2A promotes cell growth and migration via the negative regulation of p53 and positive regulation of AR and AR-V7. Mechanistically, epigenetic regulation followed by R-loop accumulation in these promoters was observed for these gene regulations. Importantly, IHC analysis demonstrated that R-loop formation increased in CRPC tissues and correlated with RNASEH2A expression levels. Notably, two small molecules targeting RNase H2 activity were found to suppress CRPC tumor growth with no significant toxic effects. Collectively, we propose that RNASEH2A overexpression is a hallmark of prostate cancer progression by maintaining genomic stability to prevent R-loop–mediated apoptosis induction. Targeting RNase H2 activity could be a potential strategy for treating CRPC tumors.Significance:RNASEH2A was demonstrated to be highly upregulated in aggressive prostate cancer to degrade R-loop accumulation and preserve genomic stability for tumor growth, suggesting that RNase H2 activity could be a promising therapeutic target.
Sex‐Based Differences in Selected Cardiac Implantable Electronic Device Use: A 10‐Year Statewide Patient Cohort
Authors: De Silva Kasun , Nassar Natasha , Badgery‐Parker Tim , Kumar Saurabh , Taylor Lee , Kovoor Pramesh , Zaman Sarah , Wilson Andrew , Chow Clara K. 
Published: August 2022

Background
Cardiac implantable electronic devices (CIEDs) include pacemakers, cardioverter defibrillators, and resynchronization therapy. This study aimed to assess CIED implantation and outcomes by sex and indication.

Methods and Results
This was a retrospective cohort study of adults with cardiovascular hospitalizations in New South Wales, Australia (2008 to 2018). CIED implantation in patients with arrhythmia, cardiomyopathy, and syncope were examined. Subcategories (complete heart block, atrial fibrillation/atrial flutter, ventricular tachycardia/ventricular fibrillation/cardiac arrest, sick sinus syndrome, and ischemic and nonischemic cardiomyopathy) were investigated. Primary outcome was implantation of CIEDs in men versus women adjusted for age and comorbidities. Secondary outcomes were trends over time, time to implant, length of stay, emergency status, and 30‐day survival. Of 1 291 258 patients with cardiovascular admissions, 287 563 had arrhythmia, cardiomyopathy, or syncope and 29 080 (2.3%) received a CIED (22 472 pacemakers, 6808 defibrillators, 3207 resynchronization therapy). Women with arrhythmia, cardiomyopathy, or syncope were less likely to have pacemakers (adjusted odds ratio [aOR], 0.78 [95% CI, 0.76–0.80]), defibrillators (aOR, 0.4, [95% CI, 0.40–0.45]) and resynchronization therapy (aOR, 0.66 [95% CI, 0.61–0.71]). Differences persisted across subcategories, including fewer pacemakers in complete heart block (aOR, 0.89 [95% CI, 0.80–0.98]) and syncope (aOR, 0.70 [95% CI, 0.63–0.79]); fewer defibrillators in ventricular tachycardia/ventricular fibrillation/cardiac arrest (aOR, 0.69 [95% CI, 0.61–0.77]); and less resynchronization therapy in cardiomyopathy (aOR, 0.62 [95% CI, 0.51–0.75]). Men and women receiving devices had higher 30‐day survival compared with those who did not receive a device, and 30‐day survival was similar between men and women receiving devices.

Conclusions
Lower CIED implantation was seen in women versus men, across nearly all indications, including complete heart block and ventricular tachycardia/ventricular fibrillation/cardiac arrest. The underuse of cardiac devices among women may arguably reflect a sex bias and requires further research.
Then What? Assessing the Military Implications of Chinese Control of Taiwan
Authors: Green Brendan Rittenhouse , Talmadge Caitlin 
Published: August 2022

Abstract
The military implications of Chinese control of Taiwan are understudied. Chinese control of Taiwan would likely improve the military balance in China's favor because of reunification's positive impact on Chinese submarine warfare and ocean surveillance capabilities. Basing Chinese submarine warfare assets on Taiwan would increase the vulnerability of U.S. surface forces to attack during a crisis, reduce the attrition rate of Chinese submarines during a war, and likely increase the number of submarine attack opportunities against U.S. surface combatants. Furthermore, placing hydrophone arrays off Taiwan's coasts for ocean surveillance would forge a critical missing link in China's kill chain for long-range attacks. This outcome could push the United States toward anti-satellite warfare that it might otherwise avoid, or it could force the U.S. Navy into narrower parts of the Philippine Sea. Finally, over the long term, if China were to develop a large fleet of truly quiet nuclear attack submarines and ballistic missile submarines, basing them on Taiwan would provide it with additional advantages. Specifically, such basing would enable China to both threaten Northeast Asian sea lanes of communication and strengthen its sea-based nuclear deterrent in ways that it is otherwise unlikely to be able to do. These findings have important implications for U.S. operational planning, policy, and grand strategy.
The Effects of Willpower on Chinese Primary and Secondary School Students’ Creativity
Authors: Chai Meng , Wan Wentao , Yan Songzhang , Lu Sichun 
Published: August 2022

Abstract
Creativity of primary and secondary school students is a major focus of research in the educational science. In this study, we examined how willpower affects the creativity of Chinese primary and secondary school students and what role the knowledge reserves and creative thinking play in this process. Specifically, we hypothesize that (a) elementary and middle school students’ willpower has a direct positive effect on their creativity, (b) willpower influences their creativity mediated by knowledge reserves and creative thinking, and (c) willpower influences their creativity development through a significant serial multiple mediating effect of knowledge reserves and creative thinking. In this study, a total of 5,176 primary and middle school students ranging from the grade 1 to 9 completed a set of questionnaires assessing willpower, knowledge reserves, creative thinking, and creativity. We used structural equation modeling to test the relationship between the variables in the Research Objectives. Results indicate that the direct positive effect of elementary and middle school students’ willpower on creativity production is weak, and the indirect effect mediated by knowledge reserves and creative thinking is significant. Results suggest that cultivating primary and secondary school students’ willpower is important to enhance their creativity, and teachers can better help Chinese primary and secondary school students develop their creativity by not only choosing appropriate teaching strategies in the process of creative education, but also by paying attention to making willpower closely integrated with the knowledge reserves and creative thinking.
Empowered for Liberation?
Authors: Padgett Isaiah C. 
Published: August 2022

Abstract
This article explores the historic divide between two prominent voices in Latin American Christianity: Pentecostalism and Liberation theology. Given the theological differences between the two camps, especially regarding socioeconomic status and theological praxis, prior attempts at dialogue have ultimately resulted in little constructive progress. However, little theological attention has been given to mutual discussion of the subject of the Holy Spirit. Therefore, this article will attempt to place understandings of pneumatology in Pentecostalism in conversation with Liberation theology, specifically the work of José Comblin. Though both groups have differing understandings of the Spirit’s role in society, it is thus argued that pneumatology and the concept of empowerment can serve as a previously neglected avenue for dialogue between Pentecostalism and Liberation theology.
Sidonia Hedwig Zäunemann im öffentlich-literarischen Diskurs der Frühaufklärung
Authors: Dziudzia Corinna 
Published: August 2022

Abstract
The focus is on the early Enlightenment poet Sidonia Hedwig Zäunemann (1711–1740) and the exemplary examination of some of her scholarly letters that have been published under her own name. Especially in the correspondence with the Hamburgische Berichte von neuen Gelehrten Sachen, Zäunemann’s case proves that female authors of the early Enlightenment were by no means excluded from the literary-public discourse of their time per se or that they primarily wrote private-sentimental letters, but rather participated with a variety of epistolary forms and could become the subject of reporting themselves.