bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalized Network Structured Models with Mixed Responses Subject to Measurement Error and Misclassification
Authors: Zhang Qihuang , Yi Grace Y. 
Published: January 2022

Abstract
Research of complex associations between a gene network and multiple responses has attracted increasing attention. A great challenge in analyzing genetic data is posited by the presence of the genetic network that is typically unknown. Moreover, mismeasurement of responses introduces additional complexity to distort usual inferential procedures. In this paper, we consider the problem with mixed binary and continuous responses that are subject to mismeasurement and associated with complex structured covariates. We first start with the case where data are precisely measured. We propose a generalized network structured model and develop a two-step inferential procedure. In the first step, we employ a Gaussian graphical model to facilitate the covariates network structure, and in the second step, we incorporate the estimated graphical structure of covariates and develop an estimating equation method. Furthermore, we extend the development to accommodating mismeasured responses. We consider two cases where the information on mismeasurement is either known or estimated from a validation sample. Theoretical results are established and numerical studies are conducted to evaluate the finite sample performance of the proposed methods. We apply the proposed method to analyze the outbred Carworth Farms White mice data arising from a genome-wide association study.
Peer likeability and victimization in young adolescents: Moderating effects of descriptive and status group norms for aggression and prosocial behaviour and network density
Authors: Aguilar‐Pardo David , Martínez‐Fernández Belén , Colmenares Fernando , Martín‐Babarro Javier 
Published: January 2022

IntroductionPrevious research has shown that peer victimization can be highly responsive to variables at the classroom level. Aggressive and prosocial norms may promote or reduce its status in classrooms. However, yet there is an apparent lack of success to explain which types of norms are more influential. This study examined the role of aggressive and prosocial descriptive and status norms in the peer victimization–status link. It also explores how the network density increases adherence to the prevailing norm in the classroom and its effect on the status of the victims.MethodData on peer acceptance and rejection, victimization, prosocial behaviour, and aggression were collected with sociometric methods in a sample of 6,600 students (M = 13.1 years, SD = 0.6; 49.2% girls), from 269 classrooms in 81 secondary schools in Spain. Group norms for aggression and for prosocial behaviour were assessed in three ways, the behaviour of all peers (class‐norm), the behaviour of most‐liked peers (likeability‐norm), and the behaviour of most salient peers (visibility‐norm).ResultsMultilevel regression analyses revealed that the negative impact of victimization on peer likeability was moderated by the classroom’s norm for prosocial behaviour, by the status norm of most visible peers’ norm for prosocial behaviour and for aggression, and by the group’s network density. The behavioural status norms of most likeable peers had no significant effect.ConclusionThese results underscore the overall importance of group context as a moderating factor of the relation between victimization and peer status in adolescents, and add to the growing body of knowledge driven by the socio‐ecological approach to the study of peer relations in developmental psychology. As implications for education, these results affect the importance of considering socio‐emotional variables in the formation of class groups in order to reduce victimization.
Monitoring foliar symptom expression in beech leaf disease through time
Authors: Fearer Carrie J. , Volk Daniel , Hausman Constance E. , Bonello Pierluigi 
Published: January 2022

AbstractWhen studying a forest disease, understanding the phenological relationship of the host tree and its pathogens is essential for identifying optimal management strategies to help prevent future spread of the disease. Since beech leaf disease (BLD) is a recently discovered disease, information about the general epidemiology and symptom phenology is largely unavailable. This study sought to answer questions related to symptom progression by conducting two observational studies on 10 trees from Cleveland Metroparks during the 2019 and 2020 growing seasons. BLD symptoms are characterized by two distinct leaf symptom types: dark green interveinal banding pattern or completely dark green and thickened leaf. Since there is evidence that the exotic nematode Litylenchus crenatae ssp. mccannii is associated with symptom development after direct inoculation into the buds, we hypothesized that symptoms would be apparent on the leaves at bud break. In our study, we visually confirmed the presence of both BLD leaf symptom types at bud break in naturally infected trees. Along with visual confirmation, a generalized linear mixed model (GLMM) showed that symptoms do not change throughout the growing season as time was not a significant variable when comparing symptoms across a growing season. Using both a Fisher's exact test and GLMM, we also determined that BLD leaf symptoms from a single leaf–bud pair do not progress in a specific or predictable pattern through subsequent growing seasons. These results formally validate the timing of BLD symptom expression and patterns of severity between years which will assist in furthering our understanding of the BLD pathosystem.
Addressing the Eltonian shortfall with trait‐based interaction models
Authors: Caron Dominique , Maiorano Luigi , Thuiller Wilfried , Pollock Laura J. 
Published: January 2022

AbstractWe have very limited knowledge of how species interact in most communities and ecosystems despite trophic relationships being fundamental for linking biodiversity to ecosystem functioning. A promising approach to fill this gap is to predict interactions based on functional traits, but many questions remain about how well we can predict interactions for different taxa, ecosystems and amounts of input data. Here, we built a new traits‐based model of trophic interactions for European vertebrates and found that even models calibrated with 0.1% of the interactions (100 out of 71 k) estimated the full European vertebrate food web reasonably well. However, predators were easier to predict than prey, especially for some clades (e.g. fowl and storks) and local food web connectance was consistently overestimated. Our results demonstrate the ability to rapidly generate food webs when empirical data are lacking—an important step towards a more complete and spatially explicit description of food webs.
The Time Moving exhibit: Exploring perceptions of time in end‐of‐life experiences
Authors: Sellen Kate , McGovern Molly , MacGregor Emma , Halleran Laura , Ly Lawrence 
Published: January 2022

AbstractBackgroundConversations about end of life rarely take place beyond healthcare spaces and in advance of imminent death. As the Canadian ageing population increases and new policies and options emerge for end‐of‐life choices, there will be an increasing need for supports for decision‐making on end of life. Time Moving was a participatory art exhibit created to engage participants in reflections on end‐of‐life experiences and the ways in which their perception of time fluctuated within these moments.DesignA participatory and constructivist approach informed decisions on exhibit design and analysis. The Time Moving exhibit was installed in a downtown university hall for 10 days during the 2019 annual DesignTO festival, open to all members of the public. The exhibit was used as the primary method of data collection. There were three prompts informed by concepts from prior work on time perception. Participants were invited to respond by drawing, writing or constructing.OutcomeThere were over 120 contributions of participants over the duration of the Time Moving exhibit. These contributions revealed new insights related to temporal perception and end‐of‐life experiences. Participants shared their perception of time during end‐of‐life experiences in a variety of ways, revealing a diversity of perceptions of time beyond calendar and clock time, including time experienced as a spiral.ConclusionsThe insights on time perception highlight opportunities for approaching dialogue on end of life and in grief support, and for exhibit as a mechanism for research and education.Patient or Public ContributionAs a public exhibit, over 120 people contributed ideas, personal stories, drawings and other creative outputs to the exhibit. An estimated 250 people visited the exhibit.
Reciprocity or backfiring? Examining the influence of realistic job previews on applicants' willingness to self‐disclose and use image protection tactics
Authors: Wilhelmy Annika , Truxillo Donald M. , Funk Friederike 
Published: January 2022

AbstractCan employers use realistic job previews to encourage applicants to open up in job interviews? We draw on theories of self‐disclosure to examine the association between realistic job previews and applicants' willingness to self‐disclose and use image protection tactics. We also examine perceived competition for the job and Honesty‐Humility as moderators. Results of a between‐subjects 2 × 2 experimental study (N = 396) show that realistic job previews were associated with decreased willingness in applicants to self‐disclose during the interview. This effect was stronger when applicants perceived high competition for the job. Organizational attractiveness and trust toward the employer mediated the effect. There were no direct effects of realistic job previews on image protection tactics. Furthermore, willingness to self‐disclose and use image protection tactics was influenced by applicants' Honesty‐Humility, but Honesty‐Humility did not moderate the relation between job preview condition and willingness to self‐disclose and use image protection tactics.
Shop scheduling in manufacturing environments: a review
Authors: Márquez Carlos R. H. , Ribeiro Celso C. 
Published: January 2022

AbstractWe review the literature about shop scheduling problems in manufacturing systems, revealing the concepts and methodologies that most impact the usage of scheduling theory in manufacturing environments. We focus our attention on the job shop and flow shop problems and their variants. We emphasize the interactions between the scheduling functions and manufacturing paradigms such as Industry 4.0, Computer Integrated Manufacturing, Computer‐Aided Process Planning, Advanced Planning and Scheduling, and Integrated Process Planning and Scheduling. We describe the main components and characteristics of the scheduling ecosystem, and we discuss how the scheduling interacts with the components that make it up and how it is affected by them. The metadata collected from the digital libraries on which the review was based (ScienceDirect, Scopus, and Elsevier) made it possible to characterize the historical evolution of the main concepts of the scheduling ecosystem in terms of scientific publications and research trends in the period 2000–2020.
Integrative analyses of probiotics, pathogenic infections and host immune response highlight the importance of gut microbiota in understanding disease recovery in rainbow trout (Oncorhynchus mykiss)
Authors: Rasmussen Jacob Agerbo , Villumsen Kasper Rømer , von Gersdorff Jørgensen Louise , Forberg Torunn , Zuo Shaozhi , Kania Per Walter , Buchmann Kurt , Kristiansen Karsten , Bojesen Anders Miki , Limborg Morten Tønsberg 
Published: January 2022

Abstract

Aims
Given the pivotal role played by the gut microbiota in regulating the host immune system, great interest has arisen in the possibility of controlling fish health by modulating the gut microbiota. Hence, there is a need to better understand of the host–microbiota interactions after disease responses to optimize the use of probiotics to strengthen disease resilience and recovery.

Methods and Results
We tested the effects of a probiotic feed additive in rainbow trout and challenged the fish with the causative agent for enteric red mouth disease, Yersinia ruckeri. We evaluated the survival, host immune gene expression and the gut microbiota composition. Results revealed that provision of probiotics and exposure to Y. ruckeri induced immune gene expression in the host, which were associated with changes in the gut microbiota. Subsequently, infection with Y. ruckeri had very little effect on microbiota composition when probiotics were applied, indicating that probiotics increased stabilisation of the microbiota. Our analysis revealed potential biomarkers for monitoring infection status and fish health. Finally, we used modelling approaches to decipher interactions between gut bacteria and the host immune gene responses, indicating removal of endogenous bacteria elicited by non-specific immune responses.

Conclusions
We discuss the relevance of these results emphasizing the importance of host–microbiota interactions, including the protective potential of the gut microbiota in disease responses.

Significance and Impact of the Study
Our results highlight the functional consequences of probiotic-induced changes in the gut microbiota post infection and the resulting host immune response.
A data framework for assessing social inequality and equity in multi‐sector social, ecological, infrastructural urban systems: Focus on fine‐spatial scales
Authors: Clark Lara P. , Tabory Samuel , Tong Kangkang , Servadio Joseph L. , Kappler Kelsey , Xu Corey Kewei , Lawal Abiola S. , Wiringa Peter , Kne Len , Feiock Richard , Marshall Julian D. , Russell Armistead , Ramaswami Anu 
Published: January 2022

AbstractCities are increasingly advancing multiple societal goals related to environmental sustainability, health, well‐being, and equity. However, there are few comprehensive data sets that address social inequality and equity across multiple infrastructure sectors, determinants, and outcomes, particularly at fine intra‐urban spatial scales. This paper: (1) Offers an overarching conceptualization of inequality and equity in multi‐sector urban systems; (2) Introduces a broad data framework to assess inequality and equity across social (S), ecological (E), infrastructural (I), and urban (U) form determinants (SEIU) and environment (E), health (H), well‐being (W), and economy and security (E) outcomes (EHWE), identifying a universe of >110 SEIU–EHWE data layers (variables) of interest; (3) Provides an illustrative data case study of a US city that synthesizes publicly available sources of the associated SEIU–EHWE data attributes, noting their availability/gaps at fine spatial scales, important to inform social inequality; (4) Discusses analytic methods to quantify inequality and spatial correlates across SEIU determinants and EHWE outcomes; and, (5) Demonstrates several use‐cases of the data framework and companion analytic methods through real‐world applied case studies that inform equity planning in applications ranging from energy sector investments to air pollution and health. The US data case study reveals data availability (covering 41 of the 113 data layers) as well as major gaps associated with EHWE outcomes at fine spatial scales, while the application examples demonstrate practical use. Overall, the SEIU–EHWE data framework provides an anchor for systematically gathering, analyzing, and informing multiple dimensions of inequality and equity in sustainable urban systems.
Bicalutamide and the new perspectives for female pattern hair loss treatment: What dermatologists should know
Authors: Carvalho Raquel de Melo , Santos Leopoldo Duailibe Nogueira , Ramos Paulo Müller , Machado Carla Jorge , Acioly Patricia , Frattini Simone Carolina , Barcaui Carlos Baptista , Donda André Luiz Vairo , Melo Daniel Fernandes 
Published: January 2022

AbstractFemale pattern hair loss (FPHL) is the most common form of alopecia in women. FPHL may compromise body image and strongly affect self‐esteem, negatively impacting quality of life. Currently, the only Food and Drug Administration (FDA) approved drug for its treatment is topical minoxidil, with a variable response rate. Recently, a few studies in FPHL have pointed out bicalutamide as an emergent selective androgen receptor antagonist with a favorable safety and tolerability profile. This review aimed to summarize and discuss the key information on this new therapy for FPHL. Bicalutamide has no diuretic effect. It does not cross the blood–brain barrier, and it has little effect on serum luteinizing hormone. Additionally, bicalutamide was found to be effective on women presenting with other features of hyperandrogenism such as seborrhea, acne, and hirsutism with mild and well‐tolerated adverse effects. Despite the high prevalence and psychosocial impairment, FPHL treatment remains challenging. Therefore, although future prospective, comparative, randomized clinical trials are essential to establish the ideal dose and efficacy of the drug, oral bicalutamide appears to be a promising option to expand the arsenal of FPHL treatment.
Hair and nail manifestations of COVID‐19
Authors: Tammaro Antonella , Adebanjo Ganiyat Adenike Ralitsa , Parisella Francesca Romana , Luzi Fabiola , Scarabello Alessandra 
Published: January 2022

AbstractEmerging literature evidence shows that the manifestations of the coronavirus disease 2019 (COVID‐19), which is the disease caused by SARS‐CoV‐2, encompass alterations of the pulmonary, cardiovascular, gastrointestinal, and neurological system. Moreover, hematologic and dermatologic manifestations have been documented.The aim of this review is to summarize the dermatologic manifestations of COVID‐19 involving the hair and nails in a narrative way.A total of 1136 patients have been reported to have de novo hair loss following COVID‐19. Notably, 958 patients experienced telogen effluvium (TE) (female/male ratio = 3,86:1), two female patients experienced anagen effluvium, and 176 people had alopecia areata (female/male ratio of 19:3).Ten patients were reported to have ungual changes following the infection with the novel coronavirus: The individuals affected were 6 women and 4 men.COVID‐19 can be associated with hair and ungual manifestations. This review summarizes the evidence regarding the hair and ungual manifestations of COVID‐19, which could be harnessed to better understand the clinical implications and pathophysiology of this disease that has been burdening society globally since December 2019.
Implication of parabens in cosmetics and cosmeceuticals: Advantages and limitations
Authors: Al‐Halaseh Lidia K. , Al‐Adaileh Sujood , Mbaideen Alsafa , Hajleh Maha N. Abu , Al‐Samydai Ali , Zakaraya Zainab Zaki , Dayyih Wael Abu 
Published: January 2022

AbstractCosmetics, cosmeceuticals, and variable healthcare products used parabens, among other excipients, for their preservative and antimicrobial activities. Paraben derivatives exhibit distinguished physiochemical properties that enable them to be compatible with the formulation of cosmetic agents in different dosage forms. In addition to their potency and efficacy, parabens are economically efficient as they have low‐manufacturing costs. Despite the desirable characteristics, the safety of parabens use is controversial after detecting these chemicals in various biological tissues after repetitive and long‐term use of formulations containing them. The use of parabens drew public health attention after scientific reports linked skin exposure to parabens with health issues, in particular, breast cancer. In response, worldwide authorities set regulations for the allowance concentrations of paraben to be used in variable cosmetic products.
Decision‐making preferences on end‐of‐life care for older people: Exploration and comparison of Japan, the Hong Kong SAR and South Korea in East Asia
Authors: Ho Lily Yuen Wah , Kwong Enid Wai Yung , Song Mi Sook , Kawakami Aki , Boo Sunjoo , Lai Claudia Kam Yuk , Yamamoto‐Mitani Noriko 
Published: January 2022

AbstractAims and ObjectivesThe aim of this study was to examine and compare decision‐making preferences on end‐of‐life care for older people in Japan, the Hong Kong SAR and South Korea.BackgroundCultural values and beliefs influence decision‐making on end‐of‐life care.DesignA cross‐sectional design was adopted.MethodsCommunity‐dwelling people aged ≥65 with additional requirements were recruited in 2016–2017 in the three regions. Their decision‐making preferences on end‐of‐life care were assessed using Pang et al.'s questionnaire. These preferences and their sociodemographic and personal experience variables were compared and analysed using univariate and multiple logistic regressions. The STROBE checklist was followed.ResultsThis study involved 415 participants. In all three regions, the most preferred decision maker and person with whom to discuss end‐of‐life care issues was a family member. Participants in the Hong Kong SAR were less likely to select a family member as their preferred decision maker than those in Japan (adjusted odds ratio = 0.129). Koreans were less likely to discuss end‐of‐life care issues with medical professionals than people in Japan (adjusted odds ratio = 0.278). More than 70% of the participants in each region indicated that they would not prefer to leave an advance directive to decide their end‐of‐life care.ConclusionOlder Asians prefer to make their own decisions after consulting others. Family members play an important role in helping older people plan their preferred end‐of‐life care arrangements, even acting as decision makers when older people become incapable of deciding for themselves.Relevance to clinical practiceSufficient information should be provided to older people and their families for the older people to determine their preferred care. Helping families to understand and support the planned care and advance directives is a strategy for maximising family compliance with the care. Continuous efforts should be made to promote advance care planning and advance directives.
Sex effects on carcass characteristics, meat quality traits and meat amino acid and fatty acid compositions in a novel Duroc line pig
Authors: Xia Ji Qiao , Liu Dong Yu , Liu Jian , Jiang Xin Peng , Wang Lan , Yang Shuo , Liu Di 
Published: January 2022

AbstractIn‐depth studies of carcass characters and meat quality could provide insight both for breeding improvement and food development in pigs. Breed and gender are two main factors affected the carcass and meat altitude, which plays important roles in pork industry. The aim of this study was to evaluate the sex effects on carcass characteristics and meat quality traits in a novel Duroc strain pig crossbred from French line, American line and Canadian line pigs. A total of 30 pigs (15 surgical‐castrated males and 15 females) with similar birthweight (1.8 ± 0.13 kg) was used in experiment. During the experiment period, all pigs were fed same commercial diets. Overall, female pigs observed higher (p < 0.05) carcass weight, slaughter backfat, loin muscle area, loin muscle depth, carcass yield, pH on 45 min, meat histidine and essential amino acid (AA) compositions, and eicosenoic, unsaturation and free fatty acids (FA) compositions compared with meat from castrated males. Whereas, castrated males’ meat showed better altitude (p < 0.05) on meat lightness, meat moisture content percentage, total umami AA and stearic acid and saturated FA compositions than those from female ones. In conclusion, the results of this study provide evidence on the sex effects on meat quality and carcass parameters in Duroc strain pigs. Furthermore, this study also give a reference on the relationship between sex and carcass and meat characteristics in Durco strain pigs.