bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of serum B7‐H3 expression, ultrasound and clinical characteristics to predict the risk of cervical lymph node metastases in papillary thyroid carcinoma by nomogram
Authors: Huang Yingcheng , Huang Zehao , Cai Huizhu , Zhuge Lingdun , Wang Shixu , Yan Dangui , Zhang Xiwei , An Changming , Niu Lijuan , Li Zhengjiang 
Published: December 2022

AbstractBackgroundImproving the preoperative diagnosis of cervical lymph node metastasis (LNM) will help improve the clinical outcomes of papillary thyroid carcinoma (PTC) patients. B7‐H3, as an immune checkpoint of the B7 family, is highly expressed in PTC tissues and related to LNM and prognosis. We aimed to explore the clinical values of serum B7‐H3 (sB7‐H3) in predicting LNM in PTC by a nomogram prediction model.MethodsFrom September 2019 to May 2021, a total of 344 PTC patients with primary surgery in our hospital were enrolled in this research. Enzyme‐linked Immunosorbent Assay (ELISA) was used to detect sB7‐H3 from the peripheral blood of PTC patients and normal controls. We created a nomogram prediction model in combination with sB7‐H3 expression, clinical and ultrasound characteristics to predict LNM in the early stage.ResultsGender (p = 0.001), age (p = 0.015), tumor size (p < 0.001), number of tumors (p = 0.021) and sB7‐H3 expression (p = 0.003) were independent risk factors for LNM in PTC. All the factors were included in the nomogram. The area under the curve (AUC) was 73.9% (95% CI, 68.12%–79.69%).ConclusionThe nomogram is helpful in assessing the risk of LNM in PTC. sB7‐H3 has excellent potential in predicting LNM in patients with PTC as an adjunctive ultrasound tool.
The nexus between gender, parental supervision, and opioid misuse among justice‐involved adolescents
Authors: Vroom Enya B. , Johnson Micah E. 
Published: December 2022

AbstractJustice‐involved adolescents (JIA) are at higher risk for opioid misuse (OM) and opioid‐related overdose than nonoffending adolescents. Untreated OM can lead to severe consequences (e.g., trauma), which may be harsher for female JIA. Therefore, examining risk and protective factors, such as parental supervision, is essential to identify factors that may impact OM. The current study used a statewide, cross‐sectional dataset including 79,960 JIA from the Florida Department of Juvenile Justice. Stratified logistic regression analyses were conducted. Results indicated that JIA who experienced sporadic or inadequate supervision had 2.14 and 3.54 higher odds, respectively, of misusing opioids compared to JIA who experienced consistent supervision. Female JIA who experienced sporadic or inadequate supervision had 2.23 and 3.70 higher odds, respectively, of misusing opioids. Results suggest parental supervision is an important protective factor that should be considered in developing prevention and treatment efforts that serve JIA who misuse opioids, especially females.
Prenatal exposure to ambient air pollution and autism spectrum disorders: Results from a family‐based case‐control study
Authors: Ghahari Nima , Yousefian Fatemeh , Najafi Ehsan 
Published: December 2022

AbstractBackgroundAutism prevalence has increased considerably, but its etiology is still poorly understood. While there have been suggestions regarding associations between air pollution exposure and neurodevelopmental disorders, several studies have looked at the effect of air pollution exposure on autism. However, the results are inconsistent. The possible role of unknown confounders is mainly blamed for this inconsistency.MethodsTo minimize confounding effects, we evaluated the impact of air pollution exposure on autism using a family‐based case‐control study. Cases were individuals with a diagnosis of autism born between 2009 and 2012 in Isfahan city, Iran. The controls did not have a previous history of autism and were cousins of the case person. The controls were matched with the autistic cases in terms of residential location and age range. For each trimester of pregnancy, carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), sulfur dioxide (SO2), and PM10 exposure were estimated using the inverse distance weighted method.ResultsThe analysis indicates a significant association between CO exposure and autism in the second trimester (OR = 1.59; p = 0.046, 95% CI: 1.01–2.51) and entire pregnancy (OR = 2.02; p = 0.049, 95% CI: 1.01–2.95). Likewise, exposure to NO2 during the second trimester (OR = 1.17; p = 0.006, 95% CI: 1.04–1.31), third trimester (OR = 1.11; p = 0.046, 95% CI: 1.01–1.24), and entire pregnancy (OR = 1.27; p = 0.007, 95% CI: 1.07–1.51) were found to be associated with increased risk of autism.ConclusionsOverall, our study found higher exposure to CO and NO2, particularly during the second and third trimesters of pregnancy, was significantly associated with a higher risk of autism.
External validation of a model to predict future chronic opioid use among hospitalized patients
Authors: Calcaterra Susan L. , Grimm Eric , Keniston Angela 
Published: December 2022

AbstractBackgroundPrevious research demonstrates an association between opioid prescribing at hospital discharge and future chronic opioid use. Various opioid guidelines and policies contributed to changes in opioid prescribing practices. How this affected hospitalized patients remains unknown.ObjectiveExternally validate a prediction model to identify hospitalized patients at the highest risk for future chronic opioid therapy (COT).DesignsRetrospective analysis of health record data from 2011 to 2022 using logistic regression.ParticipantsHospitalized adults with limited to no opioid use 1‐year prior to hospitalization.SettingsA statewide healthcare system.Main MeasurementsUsed variables associated with progression to COT in a derivation cohort from a different healthcare system to predict expected outcomes in the validation cohort.Key ResultsThe derivation cohort included 17,060 patients, of whom 9653 (56.6%) progressed to COT 1 year after discharge. Compared to the derivation cohort, in the validation cohort, patients who received indigent care (odds ratio [OR] = 0.40, 95% confidence interval [CI] =  0.27–0.59, p < .001) were least likely to progress to COT. Among variables assessed, opioid receipt at discharge was most strongly associated with progression to COT (OR = 3.74, 95% CI = 3.06–4.61, p < .001). The receiver operating characteristic curve for the validation set using coefficients from the derivation cohort performed slightly better than chance (AUC = 0.55).ConclusionsOur results highlight the importance of externally validating a prediction model prior to use outside of the derivation population. Periodic updates to models are necessary as policy changes and clinical practice recommendations may affect model performance.
Genetic defects in peroxisome morphogenesis (Pex11β, dynamin‐like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid‐phospholipid metabolism
Authors: Abe Yuichi , Wanders Ronald J. A. , Waterham Hans R. , Mandel Hanna , Falik‐Zaccai Tzipora C. , Ishihara Naotada , Fujiki Yukio 
Published: December 2022

AbstractPeroxisomes are essential organelles involved in lipid metabolisms including plasmalogen biosynthesis and β‐oxidation of very long‐chain fatty acids. Peroxisomes proliferate by the growth and division of pre‐existing peroxisomes. The peroxisomal membrane is elongated by Pex11β and then divided by the dynamin‐like GTPase, DLP1 (also known as DRP1 encoded by DNM1L gene), which also functions as a fission factor for mitochondria. Nucleoside diphosphate kinase 3 (NME3) localized in both peroxisomes and mitochondria generates GTP for DLP1 activity. Deficiencies of either of these factors induce abnormal morphology of peroxisomes and/or mitochondria, and are associated with central nervous system dysfunction. To investigate whether the impaired division of peroxisomes affects lipid metabolisms, we assessed the phospholipid composition of cells lacking each of the different division factors. In fibroblasts from the patients deficient in DLP1, NME3, or Pex11β, docosahexaenoic acid (DHA, C22:6)‐containing phospholipids were found to be decreased. Conversely, the levels of several fatty acids such as arachidonic acid (AA, C20:4) and oleic acid (C18:1) were elevated. Mouse embryonic fibroblasts from Drp1‐ and Pex11β‐knockout mice also showed a decrease in the levels of phospholipids containing DHA and AA. Collectively, these results suggest that the dynamics of organelle morphology exert marked effects on the fatty acid composition of phospholipids.
Characterizing the Macrophage Population in Patients With Idiopathic Subglottic Stenosis
Authors: Ospino Rafael , Berges Alexandra , Mafla Laura , Collins Samuel , Li Yee Chan , Lina Ioan , Gelbard Alexander , Hillel Alexander T. , Motz Kevin 
Published: December 2022

ObjectivesIdiopathic subglottic stenosis (iSGS) is characterized by progressive fibrosis and subglottic luminal narrowing. Currently, immune characterization has focused on T‐cells; however, macrophages remain largely unexplored. The goals of this study are to characterize the transcriptome of iSGS macrophages and the fibrogenic nature of identifed biomarkers.Study DesignBioinformatics and in vitro.MethodsHuman tracheal biopsies from iSGS scar (n = 4), and matched non‐scar (n = 4) regions were analyzed using single‐cell RNA‐seq (scRNA‐seq). Immunofluorescence (IF) was performed on rapidly processed autopsies (RPA) and iSGS tracheal resections (n = 4) to co‐localize S100A8/9 and CD11b. Collagen gene/protein expression was assessed in iSGS fibroblasts (n = 4) treated with protein S100A8/9 (1000 ng/ml). Macrophages were subclustered to identify distinct subpopulations.ResultsscRNA‐seq analysis revealed S100A8/S100A9 (fold change (FC) = 4.1/1.88, p < 0.001) as top differentially expressed genes in iSGS macrophages. IF exhibited increased CD11b+/S100A8/9+ cells in tracheal samples of iSGS versus RPA (26.75% ± 7.08 vs. 0.594% ± 0.974, n = 4, p = 0.029). iSGS fibroblasts treated with S100A8/9 demonstrated increased gene expression of COL1A1 (FC = 2.30 ± 0.45, p = 0.03, n = 4) and COL3A1 (FC = 2.44 ± 0.40, p = 0.03, n = 4). COL1A1 protein assays revealed an increase in the experimental group, albeit not significant, (p = 0.12, n = 4). Finally, macrophage sub clustering revealed one subpopulation as a predominant source of S100A8/S100A9 expression (FC = 7.94/5.47, p < 0.001).ConclusionsS100A8/9 is a key biomarker in iSGS macrophages. Although S100A8/9 demonstrates profibrotic nature in vitro, the role of S100A8/9+ macrophages in vivo warrants further investigation.Level of EvidenceNA Laryngoscope, 133:2308–2316, 2023
The contribution of self‐disclosure to promotional response: Examining the roles of deservingness and social class
Authors: Wang Jun , Han Bing , Liu Yi 
Published: December 2022

AbstractFacing the fact of declining sales of firms, promotions serve as an important tool to facilitate short‐term sales. Yet, marketers still face the question of promotion effectiveness based on consumer self‐disclosure behavior. In this paper, we examine the effects of self‐relevant information disclosure on promotional response as well as the mechanism and boundary conditions associated with this effect. Four studies using both real and fictitious brands across a variety of contexts were conducted to test the hypotheses and show that self‐disclosure contributes to promotional response because of the enhanced feeling of deservingness. Moreover, this research also demonstrates that self‐disclosed consumers from a lower social class are more likely to respond to promotions. Taken together, these insights contribute to the research on promotions and self‐disclosure and can be helpful to marketers by suggesting some guidelines for developing cost‐effective promotion strategies, for example, identifying the target consumer segments for promotions.
Stereotactic body radiotherapy compared with video‐assisted thoracic surgery after propensity‐score matching in elderly patients with pathologically‐proven early‐stage non‐small cell lung cancer
Authors: Liu Xiao‐ye , Gao Miao‐Miao , Cheng Ze‐yuan , Cai Zheng‐Kun , Yu Lu , Niu Geng‐Min , Li Jun‐Yi , Bai Yu , Zhao Shu‐Zhou , Song Yong‐Chun , Wang Xiao‐Guang , Dong Yang , Yu Xu‐yao , Tao Zhen , Yuan Zhi‐Yong 
Published: December 2022

AbstractObjectiveStandard medical treatment for early non‐small cell lung cancer (NSCLC) is surgery; however, stereotactic body radiotherapy (SBRT) can be a viable substitute for elderly patients who can no longer tolerate or refuse surgery. The unsurpassed care for elderly patients with early NSCLC remains inconclusive.We conducted a propensity‐score matching analysis to compare the efficacy and side‐effects of SBRT and video‐assisted thoracic surgery (VATS) in elderly patients with pathologically‐proven early NSCLC.MethodsThis single‐institution retrospective study included 310 elderly patients who underwent VATS (n = 180) or SBRT (n = 130) from January 2011 to November 2018 at the Tianjin Medical University Cancer Institute and Hospital. Sex, performance status, pathology type, Charlson Comorbidity Index, and T‐stage according to the eighth tumor node metastasis classification were considered when performing propensity‐score matching.ResultsAfter propensity‐score matching, 71 patients were included in each group for analysis. A median follow‐up period of 53.5 months was observed for all patients; 72 and 53 months for patients undergoing VATS and SBRT, respectively. Overall survival (p = 0.492), progression‐free survival (p = 0.294), locoregional recurrence‐free survival (p = 0.866), and distant metastasis‐free survival (p = 0.452) did not differ significantly between the VATS and SBRT groups. Multivariate analysis showed a significant correlation between the T‐stage and overall survival. However, treatment‐related toxicity was lower in the SBRT group than in the VATS group.ConclusionsSBRT is an option comparable with surgery for elderly patients with pathologically‐proven early‐stage NSCLC.
Improvement in the performance of focusing plasma desorption ionization by altering its counter electrode
Authors: Zheng Yajun , Zuo Qianqian , Xiang Zhicheng , Huang Yajie , Zhang Zhiping 
Published: December 2022

RationalePlasma‐based ionization sources play a vital role in rapidly analyzing diverse compounds without extensive sample pretreatment. In contrast to other sources, DC voltage‐based ionizations are more advantageous due to their high analytical sensitivity and good tandem with commercially available mass spectrometers without extra power supplies. However, their performance is at the risk of high current DC voltage and helium flow rate, which poses significant challenges to practical operation and increased expense.MethodsIn this work, we propose a novel focusing plasma desorption ionization (FPDI) in which a visible plasma beam is favorably generated between a conducting wire in a polymeric tube and a counter electrode composed of metal mesh and filter paper drilled with holes. A systematic investigation has been conducted on the influences of the geometry of drilled holes in filter paper, applied DC voltage, helium flow rate, and filter paper size. The optimized system is used to analyze various pesticides in fluid foodstuffs.ResultsCompared to metal mesh and conducting paper as the counter electrode for FPDI‐MS, combining metal mesh and filter paper drilled holes improved the analysis sensitivity by a factor of more than five. By applying the developed protocol for determining pesticides in complex matrixes such as orange juice and milk, a limit of detection as low as 1.3–3.0 ng mL−1 could be achieved.ConclusionsA novel FPDI‐MS technique has been developed by combining metal mesh and filter paper drilled with holes as the counter electrode and sample carrier. The corresponding improvement in analysis sensitivity facilitates the future expansion of FPDI‐MS applications into different pesticides and other compounds in complex matrixes.
Effects of automated skill assessment on robotic surgery training
Authors: Brown Jeremy D. , Kuchenbecker Katherine J. 
Published: December 2022

AbstractBackgroundSeveral automated skill‐assessment approaches have been proposed for robotic surgery, but their utility is not well understood. This article investigates the effects of one machine‐learning‐based skill‐assessment approach on psychomotor skill development in robotic surgery training.MethodsN = 29 trainees (medical students and residents) with no robotic surgery experience performed five trials of inanimate peg transfer with an Intuitive Surgical da Vinci Standard robot. Half of the participants received no post‐trial feedback. The other half received automatically calculated scores from five Global Evaluative Assessment of Robotic Skill domains post‐trial.ResultsThere were no significant differences between the groups regarding overall improvement or skill improvement rate. However, participants who received post‐trial feedback rated their overall performance improvement significantly lower than participants who did not receive feedback.ConclusionsThese findings indicate that automated skill evaluation systems might improve trainee self‐awareness but not accelerate early stage psychomotor skill development in robotic surgery training.
Global sampled‐data stabilization via static output feedback for a class of nonlinear uncertain systems
Authors: Cao Kecai , Qian Chunjiang , Gu Juping 
Published: December 2022

SummaryThis paper proposes some novel compensating strategies in output feedback controller design for a class of nonlinear uncertain system. With Euler approximation introduced for unmeasured state and coordinate transformation constructed for continuous system, sampled‐data stabilization under arbitrary sampling period is firstly realized for linear system using compensation between sampling period and scaling gain. Then global sampled‐data stabilization for a class of nonlinear system is studied using linear feedback domination of Lyapunov functions. Extension of obtained results to three‐dimensional system or systems under general assumptions are also presented. With the compensation schemes proposed in controller design, the sufficiently small sampling period or approximating step previously imposed is not required any more. The proposed controllers can be easily implemented using output measurements sampled at the current step and delayed output measurements sampled at the previous step without constructing state observers which has been illustrated by the numerical studies.
Colonisation of terrestrial vegetation in an intermittent river: Diversity responses to seasonal drying
Authors: Milner Victoria S. , Dutton John S. , Hayes Chloe 
Published: December 2022

AbstractIntermittent rivers are dynamic ecosystems that experience a predictable or unpredictable loss of surface water and are characterised by changing lotic, lentic (ponding) and dry habitats. Plant communities colonising dry channels during the desiccation stage can be diverse, abundant and differ in their tolerances to water availability and habitat conditions. This study examines the colonisation of terrestrial vegetation in two intermittent rivers in the United Kingdom, and whether terrestrial plant taxonomic richness and functional diversity increase during the dry phase. Six reaches were surveyed for terrestrial plants during the dry phase over a standard 100 m length every month from April to October 2021. We found the channel and bank taxonomic richness increased with drying duration. Functional traits of vegetation height, clonality, clonality richness and Ellenberg's value of light moisture also increased with stream desiccation. Bed sediment conditions (the proportion of sand and gravel) and the 12‐month antecedent percentage of zero flow days were the key drivers of plant community composition. We believe plant propagules from the riparian zone and channel vegetation on topographic high points in the channel aided plant colonisation of the riverbed once flow ceased. Past research may have underestimated the biodiversity value of intermittent rivers by failing to include the ecological importance of plants during the dry phase. Information on plant diversity of the dry phase is important to determine the overall biodiversity of intermittent rivers for their long‐term conservation and management.
An Expanded Perlite‐Based Aerogel with Oil‐Repellent Properties for Efficient Solar Evaporation in Oil‐bearing Wastewater
Authors: Guo Yuping , Tian Qi , Lu Haijing , Qu Nannan , Chen Lihua , Zhang Yuhan , Xiao Chaohu , Hasi Qi‐Meige 
Published: December 2022

AbstractSolar steam generation (SSG) has become a cutting‐edge technology to solve fresh water shortage. Herein, a neotype photothermal conversion material (CAEP‐PFO) was designed and prepared by using expanded perlite as raw material and sodium alginate as crosslinking agent, through directional freezing, surface carbonization and oil‐phobic modification. Through characterization analysis, the results showed that the prepared CAEP‐PFO has a porosity of 92 %, a light absorption of more than 88 %, and a low thermal conductivity of 0.06834 W m−1 K−1. In addition, CAEP‐PFO exhibits excellent salt resistance and oil repellency, and possess an evaporation efficiency of 78.6 % in 10 % brine and 80.2 % in oil‐bearing wastewater under the irradiation of 1 kW m−2, respectively. After 8 cycles of test, the evaporation efficiency in pure water is relatively stable, and the average evaporation efficiency can reach 84.28 %. The research may lay a foundation for the future preparation of photothermal materials and the practical application in seawater and oil‐bearing wastewater.
Discovery of Novel 1,2,4‐Oxadiazolyl Triazole Hybrids as B‐Raf Inhibitors for the Treatment of Melanoma
Authors: Pingili Divya , Svum Prasad , Raghavendra Nulgumnalli Manjunathaiah 
Published: December 2022

AbstractA fascinating oncology target is the serine/threonine‐specific protein kinase B‐Raf, which is a component of the MAPK pathway. A new series of triazolo oxadiazole derivatives have been identified as the primary scaffold of small molecule B‐Raf inhibitors. Twelve derivatives (7a–l) of triazolo oxadiazole hybrids were synthesized and characterized by spectral data. The evaluation of physicochemical and pharmacokinetic parameters demonstrated that the compounds′ solubility, lipophilicity, and compliance with Lipinski's rule are all within acceptable ranges. The anti‐proliferative capability of the synthesized derivatives was evaluated by screening them against the human melanoma cell lines Skmel‐23 and A375, which express B‐Raf in their wild‐type and mutant forms, respectively. The IC50 values differed significantly from those of the conventional doxorubicin. The IC50 values for compounds 7b and 7e against Skmel‐23 were determined to be 26.95 and 76.17 μM, respectively. The compounds 7b and 7c inhibited A375 cells at IC50 concentrations of 16.64 and 78.1 μM, respectively. Therefore, these compounds were subjected to morphological screening to detect changes in cell morphology and evaluate their apoptotic potential. The compound 7b was found to significantly inhibit both cell lines and is therefore a promising therapeutic candidate for targeting both wild‐type and mutant B‐Raf forms.
Copper‐Catalyzed C(sp2)−N Coupling of (E)‐3‐(2‐Bromophenysl)‐2‐arylacrylamides for the Synthesis of 3‐Arylquinolin‐2‐ones
Authors: Jiang Yi , Gu Jiayi , Nie Wenxing , Lu Guoqing , Xin Meixiu , Zhu Zefeng , Jiang Jiayao , Meng Yingfen , Miao Hui , Zou Yong 
Published: December 2022

AbstractA copper‐catalyzed, facile and efficient approach for the synthesis of 3‐arylquinolin‐2‐ones starting from (E)‐3‐(2‐bromophenyl)‐2‐arylacrylamides has been developed. Readily available starting materials, noble metal‐ and ligand‐free conditions, as well as good tolerability for phenolic groups make this protocol attractive and practicable.