bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Performance NIR OLEDs with Emission Peak Beyond 760 nm and Maximum EQE of 6.39%
Authors: Zhang Hongyang , Chen Zhao , Zhu Longzhi , Wu Yongquan , Xu Yuqing , Chen Shuming , Wong Wai‐Yeung 
Published: June 2022

AbstractAdvances in achieving high external quantum efficiency (EQE) of near‐infrared (NIR) organic light‐emitting diodes (OLEDs) are lagging behind that of the visible‐light OLEDs, according to the energy gap law. Herein, two structurally simple NIR‐phosphorescent Ir(III) complexes, DTCNIr and PTCNIr, with the cyclometalated ligands functionalized by the 1‐phenylisoquinoline‐4‐carbonitrile moiety and thieno/benzo[b]thiophene moiety are handily accessed within three synthetic steps. The introduction of the cyano unit can significantly lower the lowest unoccupied molecular orbitals whereas incorporating the conjugated group can elevate the highest occupied molecular orbitals of the newly designed Ir(III) complexes. The intramolecular charge transfer (ICT) transitions are enhanced due to the increased donor–acceptor interaction inside the metallophosphor. As a result, the emissions are red‐shifted to the NIR region with fast radiative decay. A maximum external quantum efficiency (EQE) of 8.11% with the emission peak at 726 nm for DTCNIr and a maximum EQE of 6.39% with the emission peak at 763 nm for PTCNIr are achieved in the NIR OLEDs by using these Ir(III) materials as the dopant emitters, a champion efficiency in the Ir(III)‐based OLEDs with the emission peak exceeding 760 nm.
Compound heterozygous variants of the NARS2 gene in siblings with developmental delay, epilepsy, and neonatal diabetes syndrome
Authors: Yagasaki Hideaki , Sano Fumikazu , Narusawa Hiromune , Watanabe Daisuke , Kaga Yoshimi , Kobayashi Koji , Asano Yoshihiro , Nagata Miho , Yonei Ayumi , Inukai Takeshi 
Published: June 2022

AbstractNeonatal diabetes mellitus (NDM) with developmental delay and epilepsy is classified as developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome. The majority of DEND syndrome are due to severely damaging variants of K‐ATP channels, and few mitochondria‐related genes have been reported. We report here two Japanese siblings who were clinically diagnosed with DEND syndrome in whom NARS2 compound heterozygous variants were detected. Patient 1 was a 3‐year‐old girl and presented with diabetes ketoacidosis at 3 months old. Patient 2 was a 1‐year‐old boy who presented with severe hyperglycemia and started insulin therapy at 3 days old. After the first episodes, they both presented with severe developmental delay, hearing loss and treatment‐resistant epilepsy accompanied by progressive brain atrophy. Whole‐exome sequencing revealed compound heterozygous NARS2 p.R159C and p.L217V variants, and the GATA4 p.P407Q variant in both patients. They were treated by mitochondrial supportive therapy of vitamin B1, L‐carnitine, and coenzyme Q10. Patient 2 was withdrawn from insulin therapy at 6 months old. This is the first report of NDM in which variants of the NARS2 gene coding mitochondrial protein were detected. Genetic analysis including mitochondrial genes should be considered in patients with neonatal onset diabetes associated with neurogenic symptoms.
Longitudinal Retinal Changes in MOGAD
Authors: Oertel Frederike Cosima , Sotirchos Elias S. , Zimmermann Hanna G. , Motamedi Seyedamirhosein , Specovius Svenja , Asseyer Eva Susanna , Chien Claudia , Cook Lawrence , Vasileiou Eleni , Filippatou Angeliki , Calabresi Peter A. , Saidha Shiv , Pandit Lekha , D'Cunha Anitha , Outteryck Olivier , Zéphir Hélène , Pittock Sean , Flanagan Eoin P. , Bhatti M. Tariq , Rommer Paulus S. , Bsteh Gabriel , Zrzavy Tobias , Kuempfel Tania , Aktas Orhan , Ringelstein Marius , Albrecht Philipp , Ayzenberg Ilya , Pakeerathan Thivya , Knier Benjamin , Aly Lilian , Asgari Nasrin , Soelberg Kerstin , Marignier Romain , Tilikete Caroline Froment , Cobo Calvo Alvaro , Villoslada Pablo , Sanchez‐Dalmau Bernardo , Martinez‐Lapiscina Elena H. , Llufriu Sara , Green Ari J. , Yeaman Michael R. , Smith Terry J. , Brandt Alexander U. , Chen John , Paul Friedemann , Havla Joachim ,   with the GJCF International Clinical Consortium for NMOSD and the CROCTINO study group
Published: June 2022

ObjectivePatients with myelin oligodendrocyte glycoprotein antibody (MOG‐IgG)‐associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro‐axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON‐independent retinal atrophy can be detected in MOGAD.MethodsEighty patients with MOGAD and 139 healthy controls (HCs) were included. OCT data was acquired with (1) Spectralis spectral domain OCT (MOGAD: N = 66 and HCs: N = 103) and (2) Cirrus high‐definition OCT (MOGAD: N = 14 and HCs: N = 36). Macular combined ganglion cell and inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) were quantified.ResultsAt baseline, GCIPL and pRNFL were lower in MOGAD eyes with a history of ON (MOGAD‐ON) compared with MOGAD eyes without a history of ON (MOGAD‐NON) and HCs (p < 0.001). MOGAD‐NON eyes had lower GCIPL volume compared to HCs (p < 0.001) in the Spectralis, but not in the Cirrus cohort. Longitudinally (follow‐up up to 3 years), MOGAD‐ON with ON within the last 6–12 months before baseline exhibited greater pRNFL thinning than MOGAD‐ON with an ON greater than 12 months ago (p < 0.001). The overall MOGAD cohort did not exhibit faster GCIPL thinning compared with the HC cohort.InterpretationOur study suggests the absence of attack‐independent retinal damage in patients with MOGAD. Yet, ongoing neuroaxonal damage or edema resolution seems to occur for up to 12 months after ON, which is longer than what has been reported with other ON forms. These findings support that the pathomechanisms underlying optic nerve involvement and the evolution of OCT retinal changes after ON is distinct in patients with MOGAD. ANN NEUROL 2022;92:476–485
A Resonating B, N Covalent Bond and Coordination Bond in Aromatic Compounds and Conjugated Polymers
Authors: Shao Xingxin , Liu Mengyu , Liu Jun , Wang Lixiang 
Published: June 2022

AbstractWe herein report an organoboron compound (SBN‐1) based on N−B←N units with a balanced resonance hybrid of B, N single bond (B−N) and B, N coordination bond (B←N). Despite the different chemical environments of the two nitrogen atoms in the N−B←N unit, the single‐crystal structure reveals that the two B, N bonds have similar bond lengths of ca. 1.55 Å and are almost equivalent. The resonance nature of the two B, N bonds contributes to the excellent chemical stability and photostability ofSBN‐1. The N−B←N units inSBN‐1show a strong electron‐withdrawing capability and large dipole, resulting in a red‐shifted absorption spectrum, downshifted LUMO/HOMO energy levels, and drastically altered molecular packing behaviors in solid state.SBN‐1can be used as a building block to construct small band gap conjugated polymers. The resonance of B, N bonds discovered in this work provides new insight into the design of stable organoboron small molecules and polymers for practical applications.
Direct Enantioselective Addition of Alkynes to Imines by a Highly Efficient Palladacycle Catalyst
Authors: Pfeffer Camilla , Probst Patrick , Wannenmacher Nick , Frey Wolfgang , Peters René 
Published: June 2022

AbstractEnantiopure propargylic amines are highly valuable synthetic building blocks. Much effort has been devoted to develop methods for their preparation. The arguably most important strategy is the 1,2‐addition of alkynes to imines. Despite remarkable progress, the known methods using Zn and Cu catalysts suffer from the need for high catalyst loadings, typically ranging from 2–60 mol % for neutral aldimine substrates. Here we report a planar chiral Pd complex acting as very efficient catalyst for direct asymmetric alkyne additions to imines, requiring very low catalyst loadings. Turnover numbers of up to 8700 were accomplished. Our investigation suggests that a Pd‐acetylide complex is generated as a catalytically relevant intermediate by the aid of an acac ligand acting as internal catalytic base. It is shown that the catalyst is quite stable under the reaction conditions and that product inhibition is not an issue. A total of 39 examples is shown which all yielded almost enantiopure products.
Input‐to‐state stability for discrete‐time time‐varying impulsive switched delayed systems with asynchronous phenomena
Authors: Fu Zhiwen , Peng Shiguo 
Published: June 2022

AbstractThis paper studies the input‐to‐state stability (ISS) for a class of discrete‐time time‐varying impulsive switched delayed systems, in which the asynchronous phenomena are considered. Asynchronous phenomena here include two implications: asynchronous impulses and switches and asynchronous switching. The former means that the events, that is, impulses and switches, are not necessary to occur simultaneously, while the latter indicates that the actual switching modes and related controllers or specified modes do not coincide. Applying the mode‐dependent concept to impulses and switches, both the improved Krasovskii‐type and Razumikhin‐type ISS criteria are provided. The time differences of Lyapunov functionals or functions here are sign‐changing and time‐varying, releasing from the traditional assumption that always requires negative definiteness. Meanwhile, in this paper, ISS or non‐ISS subsystems and stabilizing or destabilizing impulses are taken into account. Finally, three numerical examples are given to illustrate the effectiveness of the proposed results.
Development and validation of a leukocyte‐associated immunoglobulin‐like receptor‐1 prognostic signature for lower‐grade gliomas
Authors: Fang Zhansheng , Lin Li , Tu Zewei , Zhu Xingen , Li Jingying , Luo Pengxiang , Huang Kai , Wu Lei 
Published: June 2022

AbstractObjectiveLeukocyte‐associated immunoglobulin‐like receptor‐1 (LAIR‐1), is an immunosuppressive receptor, widely expressed by immune cells, but the part of LAIR‐1 in glioma progression remains unclear. The purpose of this study was to explore the relationship between LAIR‐1 expression and the development of lower‐grade glioma (LGG) using publicly available data sets.MethodsWe took advantage of The Cancer Genome Atlas (TCGA) to analyze the expression of LAIR‐1 in patients with LGG. Second, Kaplan‐Meier methods and univariate and multivariate Cox regression analyses were used to examine the clinical significance of LAIR‐1 expression in combination with CGGA databases, and then receiver operating characteristic curve analysis was used to verify the prognostic utility of LAIR‐1. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene set enrichment analysis (GSEA) were used to explore the function of LAIR‐1. Analysis of the correlation with immune infiltration was conducted using the ESTIMATE algorithm and single sample gene set enrichment analysis.ResultsOur results showed that LAIR‐1 expression to be positively correlated with malignant clinicopathologic features of LGG. Univariate analysis and multivariate analysis revealed that overexpression of LAIR‐1 was correlated with a worse prognosis in patients. A nomogram model combining LAIR‐1 was more useful in guiding clinical diagnosis, and functional enrichment analysis showed that malignant development of glioma was closely affiliated with the tumor immune microenvironment.ConclusionThese results indicate that LAIR 1 is a latent marker for determining the prognosis of LGG patients. LAIR 1 may also participate a critical part in TIME of LGG by regulating the infiltration of immune cells, suggesting that LAIR 1 might be used as a therapeutic target to regulate the antitumor immune response.
Oral brush biopsy using liquid‐based cytology is a reliable tool for oral cancer screening: A cost‐utility analysis
Authors: Idrees Majdy , Farah Camile S. , Sloan Philip , Kujan Omar 
Published: June 2022

BackgroundThis study aimed to assess the diagnostic utility and associated cost of oral liquid‐based brush cytology (OLBC) in the diagnosis of oral cancer and oral potentially malignant disorders (OPMDs).MethodsA total of 284 patients with oral mucosal lesions were included. OLBC samples were collected from all patients immediately before undergoing surgical biopsies. A liquid‐based cytology slide was prepared from each OLBC sample for cytological evaluation using the modified 2014 Bethesda cytology system. The results and the cost were compared with the histopathological outcomes.ResultsThe level of agreement between the two approaches was very good (weighted kappa = 0.824). The accuracy of OLBC in differentiating between the different diagnostic groups was 91.69%, whereas the associated sensitivity and specificity were 79.23% and 94.81%, respectively. The estimated cost of each OLBC sample was at least 26% less than the cost of a single biopsy and more than 42% less in cases of multiple biopsied lesions.ConclusionsThe proposed modifications of the Bethesda system can be adopted as a standardized system for oral cytological assessment. Our findings support OLBC as a reliable adjunct to surgical biopsy in the diagnosis of OPMDs. This tool has potential for oral cancer–finding and surveillance programs.
Weather parameters forecasting with time series using deep hybrid neural networks
Authors: Yalçın Sercan 
Published: June 2022

SUMMARYWeather forecasting has recently gained great importance in terms of predicting potential disasters, taking precautions, and increasing the quality of life around the world. Researchers apply optimization and artificial intelligence techniques to make weather forecasts based on various nature parameters. In this study, it is proposed a weather condition forecasting scheme with time series using deep hybrid neural networks. In the proposed scheme, the essential parameters for weather forecasting, namely, relative humidity, temperature, atmospheric pressure, and wind speed are trained and predicted with long short‐term memory (LSTM)‐convolutional neural networks (CNNs) models in a hybrid way. The values represented by the input neurons are first passed through the CNN layers for a clearer and more accurate estimation of the data. Then, after fine‐tuning, the results are sent to the LSTM block. The proposed hybrid deep method has been compared with both machine learning and deep learning methods According to the results, running the proposed method, the RMSE, MADE, and MAPE values are 1.82, 1.64, 1.21 for temperature, 7.12, 6.58, and 4.63 for relative humidity, 2.61, 2.36, and 1.86 for atmospheric pressure, and 1.06, 0.85, and 0.52 for wind speed, respectively.
Using seabird and whale distribution models to estimate spatial consumption of krill to inform fishery management
Authors: Warwick‐Evans V. , Kelly N. , Dalla Rosa L. , Friedlaender A. , Hinke J. T. , Kim J. H. , Kokubun N. , Santora J. A. , Secchi E. R. , Seyboth E. , Trathan P. N. 
Published: June 2022

AbstractEcosystem dynamics at the northwest Antarctic Peninsula are driven by interactions between physical and biological processes. For example, baleen whale populations are recovering from commercial harvesting against the backdrop of rapid climate change, including reduced sea ice extent and changing ecosystem composition. Concurrently, the commercial harvesting of Antarctic krill is increasing, with the potential to increase the likelihood for competition with and between krill predators and the fishery. However, understanding the ecology, abundance, and spatial distribution of krill predators is often limited, outdated, or at spatial scales that do not match those desired for effective fisheries management. We update current knowledge of predator dependence on krill by integrating telemetry‐based data, at‐sea observational surveys, estimates of predator abundance, and physiological data to estimate the spatial distribution of krill consumption during the austral summer by three species ofPygoscelispenguin, 11 species of flying seabirds, one species of pinniped, and two species of baleen whale. Our models show that the majority of important areas for krill predator foraging are close to penguin breeding colonies in nearshore areas where humpback whales also regularly feed, and along the shelf‐break, though we caution that not all known krill predators are included in these analyses. We show that krill consumption is highly variable across the region, and often concentrated at fine spatial scales, emphasizing the need for the management of the local krill fishery at relevant temporal and spatial scales. We also note that krill consumption by recovering populations of krill predators provides further evidence in support of the krill surplus hypothesis, and highlight that despite less than comprehensive data, cetaceans are likely to consume a significant proportion of the krill consumed by natural predators but are not currently considered directly in the management of the krill fishery. If management of the krill fishery is to be precautionary and operate in a way that minimizes the risks to krill predator populations, it will be necessary in future analyses, to include up‐to‐date and precise abundance and consumption estimates for pack‐ice seals, finfish, squid, and other baleen whale species not currently considered.
A Steroidal Molecular Rotor with Fast Solid‐State Dynamics Obtained by Crystal Engineering: Role of the Polarity of the Stator
Authors: Labra‐Vázquez Pablo , Ochoa María E. , Alfonso‐Herrera Luis A. , Vera Marco A. , Farfán Norberto , Santillan Rosa 
Published: June 2022

AbstractA set of Steroidal Molecular Rotors (SMRs) were synthesized and characterized employing a Sonogashira cross‐coupling reaction as the key synthetic step. The static dipole moment (μ0) of the stator was examined as a crystal engineering criterium that could determine the easiness with which the rotator participates in the high energy supramolecular interactions that frequently preclude rotation in this class of molecular machines. The strategy is critically evaluated through theoretical/experimental analyses, featuring SXRD experiments and QM/MM computations of the rotational activation energy (Ea), allowing us to propose, within the systems studied, a potential correlation between the use of stators with lower μ0and a lowering of theEavalue. Results from solid‐state NMR revealed that one of the most promising compounds indeed hosts fast rotational motion (above 25–30 kHz), standing as a rare example of a SMR with fast rotation within a crowded crystallographic environment.
Molecular Iodine Mediated Oxidation of Arylated α‐Carbonyl Sulfoxonium Ylides to 1,2‐Dicarbonyl‐Containing Compounds
Authors: Echemendía Radell , De Jesus Matheus P. , Furniel Lucas G. , Day David Philip , Burtoloso Antonio C. B. 
Published: June 2022

AbstractSulfoxonium ylides in recent years have proved to be versatile building blocks and have found applications in the synthesis of structurally diverse organic molecules. In this work, we report a new oxidative, molecular iodine‐mediated transformation on sterically encumbered arylated sulfoxonium ylides, which give access to 1,2‐dicarbonyl containing compounds. Twenty‐six examples have been realized (47–92 % yields), with structural diversity modified at two key sites on the sulfoxonium ylide reactants. Furthermore, the protocol benefits from the use of inexpensive molecular iodine to mediate the oxidation and, from a sustainability viewpoint, short reaction times (30 minutes), ambient temperature, and ethyl acetate as a greener reaction solvent. Experimental studies also gave insight to the mechanism of the reaction, involving DMSO as an oxygen source.
Problematic eating behaviours of autistic women—A scoping review
Authors: Schröder Sabrina S. , Danner Unna N. , Spek Annelies A. , van Elburg Annemarie A. 
Published: June 2022

AbstractAimEating and feeding behaviours of autistic individuals and related consequences have been mainly investigated in autistic children or in autistic adults with intellectual disabilities. Behaviours such as food selectivity or food neophobia have been shown to persist into adolescence and adulthood and are associated with aversive consequences. However, much less is known about the eating behaviours of autistic adults without intellectual disabilities, especially those of women. By means of a scoping review, we aim to assess the extent of the scientific literature on what is known about the eating behaviours of these women and the possible consequences of such eating behaviour.MethodMedline, Cochrane, PubMed and PsycInfo databases were searched according to Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) guidelines.ResultsFive studies met the eligibility criteria and were included in this review. Autistic women not only reported high levels of eating behaviour frequently seen in autism spectrum disorders (ASD), but also high levels of disordered eating behaviour, similar to that of women with eating disorders.ConclusionsAutistic women seem to exhibit high levels of eating behaviour frequently seen in ASD as well as disordered eating behaviour. Future research needs to shed light on what underlies these problematic eating behaviours, in order to help to adapt current treatment modalities to meet the unique needs of these women.
Experimental investigation for the impact of chlorite dissolution on CO2 mineral trapping in a sandstone‐brine‐CO2 system
Authors: Cheng Jianmei , Yu Hui , Liu Ning , Yu Ying , Ahmat Kaisar , Zhao Ruirui 
Published: June 2022

AbstractThe mineral trapping of CO2 in geological formation is the most promising and safe mechanism for permanent carbon storage. The chlorite shows a great influence on the form and capacity of carbon storage in sandstone reservoirs due to its wide distribution and strong chemical activity. In this paper, to better understand the dissolution process of chlorite after the injection of CO2 and its potential impacts on carbon mineral trapping patterns, two sets of hydrothermal batch reactions toward chlorite and CO2 fluid are conducted at elevated temperature‐pressure conditions (120 °C/180 °C, 18 MPa), considering the effects of extra calcite addition and the initial concentration of Ca2+ in solution. During reactions, the changes in water chemistry and mineral surface morphology are monitored through effluent sampling and scanning electron microscope (SEM) observation, respectively and they are further analyzed in PHREEQC by the method of mineral saturation index. It is found that the simultaneous dissolution of chlorite and calcite in CO2 saturated solutions will lead to a competition for H+, and the formation of massive surface complex CaHCO3– by Ca2+ in the initial solutions will lead to the consumption of H+. These inhibit the proton‐promoted dissolution of chlorite. But when the concentration of Ca2+ is increased to meet the requirements for ankerite precipitation, the demand of ankerite precipitation for elements Fe and Mg will conversely promote the chlorite dissolution. Besides, the concentration of Ca2+ required for the precipitation of ankerite is relatively low, which implies that the injected CO2 can be mineralized and trapped by the chlorite dissolution process easily. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.