bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sixth sense in the deep-sea: the electrosensory system in ghost shark Chimaera monstrosa
Authors: Bottaro Massimiliano 
Published: June 2022

AbstractAnimals that continually live in deep sea habitats face unique challenges and require adaptive specializations solutions in order to locate and identify food, predators, and conspecifics. The Ampullae of Lorenzini are specialized electroreceptors used by chondrichthyans for important biological functions. Ampullary organs of the ghost shark Chimaera monstrosa, a deep-sea species commonly captured as by-catch in the bottom trawl fishery, are here described for the first time using macroscopic, ultrastructural and histological approaches. The number of ampullary pores in C. monstrosa is about 700, distributed into the whole cephalic section of C. monstrosa, and organized in12 pore clusters and they are arranged into different configurations and form a distinct morphological pattern for this species, showing some anatomical peculiarities never described before in others cartilaginous fishes and may constitute an evolutionary adaptation of this ancient chondrichthyan species to the extreme environmental conditions of its deep sea niche.
Rule extraction from biased random forest and fuzzy support vector machine for early diagnosis of diabetes
Authors: Hao Jingwei , Luo Senlin , Pan Limin 
Published: June 2022

AbstractDue to concealed initial symptoms, many diabetic patients are not diagnosed in time, which delays treatment. Machine learning methods have been applied to increase the diagnosis rate, but most of them are black boxes lacking interpretability. Rule extraction is usually used to turn on the black box. As the number of diabetic patients is far less than that of healthy people, the rules obtained by the existing rule extraction methods tend to identify healthy people rather than diabetic patients. To address the problem, a method for extracting reduced rules based on biased random forest and fuzzy support vector machine is proposed. Biased random forest uses the k-nearest neighbor (k-NN) algorithm to identify critical samples and generates more trees that tend to diagnose diabetes based on critical samples to improve the tendency of the generated rules for diabetic patients. In addition, the conditions and rules are reduced based on the error rate and coverage rate to enhance interpretability. Experiments on the Diabetes Medical Examination Data collected by Beijing Hospital (DMED-BH) dataset demonstrate that the proposed approach has outstanding results (MCC = 0.8802) when the rules are similar in number. Moreover, experiments on the Pima Indian Diabetes (PID) and China Health and Nutrition Survey (CHNS) datasets prove the generalization of the proposed method.
Association of the presence of allergic disease with subsequent risk of liver cancer in a nationwide retrospective cohort among Koreans
Authors: Kim Ji Ah , Park Sun Jae , Choi Seulggie , Chang Jooyoung , Jeong Seogsong , C.Ahn Joseph , Lee Gyeongsil , Son Joung Sik , Park Sang Min 
Published: June 2022

AbstractA number of studies have proposed an inverse association between allergic diseases and risk of cancer, but only a few studies have specifically investigated the risk of primary liver cancer, including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). The aim of this study was to evaluate the association of allergic diseases with risk of primary liver cancer. We conducted a retrospective cohort study of the Korean National Health Insurance Service database consisted of 405,512 Korean adults ages 40 and above who underwent health screening before January 1st, 2005. All participants were followed up until the date of liver cancer, death, or December 31st, 2013, whichever happened earliest. Those who died before the index date or had pre-diagnosed cancer were excluded from the analyses. Cox proportional hazards regression was used to determine the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for risk of primary liver cancer according to the presence of allergic diseases, including atopic dermatitis, asthma, and allergic rhinitis. The aHR (95% CI) for overall liver cancer among allergic patients was 0.77 (0.68–0.87) compared to those without allergic disease. Allergic patients had significantly reduced risk of HCC (aHR, 0.72; 95% CI 0.62–0.85) but not ICC (aHR, 0.95; 95% CI 0.73–1.22). The presence of allergies was associated with significantly lower risk of liver cancer among patients whose systolic blood pressure is lower than 140 mmHg (aHR, 0.64; 95% CI 0.62–0.78 for overall liver cancer; aHR, 0.64; 95% CI 0.52–0.78 for HCC) but this effect was not observed among patients whose systolic blood pressure is higher than 140 mmHg (aHR, 0.91; 95% CI 0.71–1.18 for overall liver cancer; aHR, 0.91; 95% CI 0.71–1.18 for HCC) The aHR (95% CI) for overall liver cancer of allergic patients with and without chronic hepatitis virus infection were 0.60 (95% CI 0.44–0.81) and 0.77 (95% CI 0.64–0.93), respectively. In addition, allergic patients without cirrhosis showed significantly lower risk of overall liver cancer (aHR, 0.73; 95% CI 0.63–0.83). Patients with allergic diseases have significantly lower risk of primary liver cancer compared to those without allergic diseases, which supports the rationale for immunotherapy as an effective treatment for liver cancer.
AGE/RAGE axis regulates reversible transition to quiescent states of ALK-rearranged NSCLC and pancreatic cancer cells in monolayer cultures
Authors: Kadonosono Tetsuya , Miyamoto Kotaro , Sakai Shiori , Matsuo Yoshiyuki , Kitajima Shojiro , Wang Qiannan , Endo Minori , Niibori Mizuho , Kuchimaru Takahiro , Soga Tomoyoshi , Hirota Kiichi , Kizaka-Kondoh Shinae 
Published: June 2022

AbstractCancer recurrence due to tumor cell quiescence after therapy and long-term remission is associated with cancer-related death. Previous studies have used cell models that are unable to return to a proliferative state; thus, the transition between quiescent and proliferative states is not well understood. Here, we report monolayer cancer cell models wherein the human non-small cell lung carcinoma cell line H2228 and pancreatic cancer cell line AsPC-1 can be reversibly induced to a quiescent state under hypoxic and serum-starved (HSS) conditions. Transcriptome and metabolome dual-omics profiles of these cells were compared with those of the human lung adenocarcinoma cell line A549, which was unable to enter a quiescent state under HSS conditions. The quiescence-inducible cells had substantially lower intracellular pyruvate and ATP levels in the quiescent state than in the proliferative state, and their response to sudden demand for energy was dramatically reduced. Furthermore, in quiescence-inducible cells, the transition between quiescent and proliferative states of these cells was regulated by the balance between the proliferation-promoting Ras and Rap1 signaling and the suppressive AGE/RAGE signaling. These cell models elucidate the transition between quiescent and proliferative states, allowing the development of drug-screening systems for quiescent tumor cells.
Nox4 expression in osteo-progenitors controls bone development in mice during early life
Authors: Chen Jin-Ran , Lazarenko Oxana P. , Blackburn Michael L. , Chen Jennifer F. , Randolph Christopher E. , Zabaleta Jovanny , Schroder Katrin , Pedersen Kim B. , Ronis Martin J. J. 
Published: June 2022

AbstractTightly regulated and cell-specific NADPH-oxidases (Nox) represent one of the major sources of reactive oxygen species (ROS) signaling molecules that are involved in tissue development and stem cell self-renewal. We have characterized the role of Nox4 in osteo-progenitors during postnatal bone development. Nox4 expression in bone and ROS generation were increased during early osteoblast differentiation and bone development. Stromal osteoblastic cell self-renewal, proliferation and ROS production were significantly lower in samples from whole-body Nox4 knockout mice (Nox4-/-) and conditional knockout (CKO) mice with depletion of Nox4 in the limb bud mesenchyme compared with those from control mice (Nox4fl/fl), but they were reversed after 9 passages. In both sexes, bone volume, trabecular number and bone mineral density were significantly lower in 3-week old CKO and Nox4-/- mice compared with Nox4fl/fl controls. This was reflected in serum levels of bone formation markers alkaline phosphatase (ALP) and procollagen 1 intact N-terminal propeptide (P1NP). However, under-developed bone formation in 3-week old CKO and Nox4-/- mice quickly caught up to levels of control mice by 6-week of age, remained no different at 13-week of age, and was reversed in 32-week old male mice. Osteoclastogenesis showed no differences among groups, however, CTX1 reflecting osteoclast activity was significantly higher in 3-week old male CKO and Nox4-/- mice compared with control mice, and significantly lower in 32-week old Nox4-/- mice compared with control mice. These data suggest that Nox4 expression and ROS signaling in bone and osteoblastic cells coordinately play an important role in osteoblast differentiation, proliferation and maturation.
Infrared plasmons in ultrahigh conductive PdCoO2 metallic oxide
Authors: Macis Salvatore , Tomarchio Luca , Tofani Silvia , Piccirilli Federica , Zacchigna Michele , Aglieri Vincenzo , Toma Andrea , Rimal Gaurab , Oh Seongshik , Lupi Stefano 
Published: June 2022

AbstractPdCoO2 layered delafossite is the most conductive compound among metallic oxides, with a room-temperature resistivity of nearly $$2\,\mu \Omega \,{{{{{\rm{cm}}}}}}$$
2

μ
Ω

cm
, corresponding to a mean free path of about 600 Å. These values represent a record considering that the charge density of PdCoO2 is three times lower than copper. Although its notable electronic transport properties, PdCoO2 collective charge density modes (i.e. surface plasmons) have never been investigated, at least to our knowledge. In this paper, we study surface plasmons in high-quality PdCoO2 thin films, patterned in the form of micro-ribbon arrays. By changing their width W and period 2W, we select suitable values of the plasmon wavevector q, experimentally sampling the surface plasmon dispersion in the mid-infrared electromagnetic region. Near the ribbon edge, we observe a strong field enhancement due to the plasmon confinement, indicating PdCoO2 as a promising infrared plasmonic material.
Salicylic acid and jasmonic acid crosstalk in plant immunity
Authors: Hou Shiji , Tsuda Kenichi 
Published: June 2022

Abstract
The phytohormones salicylic acid (SA) and jasmonic acid (JA) are major players in plant immunity. Numerous studies have provided evidence that SA- and JA-mediated signaling interact with each other (SA-JA crosstalk) to orchestrate plant immune responses against pathogens. At the same time, SA-JA crosstalk is often exploited by pathogens to promote their virulence. In this review, we summarize our current knowledge of molecular mechanisms for and modulations of SA-JA crosstalk during pathogen infection.
Effects of a Computer Training to Teach Spanish Book-Sharing Strategies to Mothers of Emergent Bilinguals at Risk of Developmental Language Disorders: A Single-Case Design Study
Authors: Rivera Pérez Jean F. , Regalado Alice , Lund Emily 
Published: June 2022

Purpose:
The purpose of this research is to examine the effects of a computer app–based training program for caregivers on caregiver behavior to enhance Spanish language in emergent bilinguals at risk for developmental language disorders.

Method:
This study followed a single-case, multiple-baseline design. An app-based language training program was developed based on the Teach-Model-Coach-Review adult learning instructional approach. Six mothers were trained on three language-facilitation strategies (Completion, Distancing, and Questioning) while reading to their children in Spanish. The training focused on one of the three strategies at a time, and mothers were given access to training once a week. Mothers were recorded while they read to their children during three phases: prior to the training (baseline), during 2 training weeks (training phase), and after training was provided (maintenance).

Results:
A visual analysis of the data (percent nonoverlapping data complemented with Tau-U analysis) indicated a functional relation between the training program and the use of strategies by the participants for Distancing and Completion, and there was a less robust, moderate effect for Questioning strategy for a couple of participants.

Conclusions:
The computer training may serve as a tool for instructors who want to educate Spanish-speaking mothers in the use of evidence-based language strategies at home. Further research is needed to determine how this parent training could result in long-term use of strategies during reading times and what factors are associated with the learning and subsequent use of these strategies with children.
Augmentative and Alternative Communication in the Classroom: Teacher Practices and Experiences
Authors: Leatherman Elizabeth M. , Wegner Jane R. 
Published: June 2022

Purpose:
This study explored the practices and experiences of teachers who teach students using augmentative and alternative communication (AAC), more specifically, speech-generating devices (SGDs).

Method:
Nine teachers (one general education, eight special education) from four countries participated in semistructured interviews. A generic qualitative approach was taken to inductively code interview transcripts and establish descriptive themes.

Results:
Three themes emerged from the data. The teaching experience theme captured teachers' feelings, role, collaboration with others, knowledge and learning around AAC, and challenges teaching students who use SGDs. The teaching practices theme included curricula that teachers use, instructional planning, materials and adaptations, instructional strategies, and methods for student evaluation and progress monitoring. Finally, the overarching views and practices theme captured teachers' beliefs and interpretation of the educational system for students using SGDs, as well as teachers' overarching views on communication and approach to AAC implementation.

Conclusions:
In sharing their perspectives and practices, teachers highlighted a number of constructs that speech-language pathologists could consider when responding to and supporting teacher and student needs. The findings of this study have implications for facilitating collaborative relationships and supporting the use of AAC in schools. Discussion on how educational placement can influence teacher experiences and student outcomes is also integrated into the context of this study.
Code design and interception probability of optical fibre communication system based on optical coding
Authors: Liu Mandong , Ji Jianhua , Wang Ke , Xu Ming 
Published: June 2022

AbstractTraditional optical orthogonal code has small code cardinality, which is vulnerable to the brute‐force attacks by eavesdroppers. In order to improve the anti‐interception performance of optical fibre communication system based on optical coding, a new family of optical code with large code cardinality is proposed. Based on information‐theoretic security, the interception probability of optical fibre coding system is proposed and defined, and the expression of the interception probability is derived for the first time. The influences of extraction distance, extraction ratio, the number of interfering users and the code length on the interception probability are analysed quantitatively. The anti‐interception performance of the optical coding system is investigated by numerical analysis and OptiSystem simulation. It is shown that reliability and anti‐interception performance can be achieved simultaneously by selecting appropriate code parameters and the number of interfering users.
EAGAN: Event‐based attention generative adversarial networks for optical flow and depth estimation
Authors: Lin Xiuhong , Yang Chenhui , Bian Xuesheng , Liu Weiquan , Wang Cheng 
Published: June 2022

AbstractEvent camera is a new vision sensor that produces independent asynchronous responses to each pixel's change of illumination intensity. The unique principle of event camera has many advantages over traditional cameras, such as low latency, high temporal resolution, and high dynamic range (HDR). These advantages make event camera ideal for dealing with high speed, HDR visual tasks, especially in automatic driving scenes. In this study, we propose an image generation network named Event‐based attention generative adversarial networks (EAGAN), which simultaneously deals with optical flow and depth estimation of monocular event camera data. In addition to the innovative network architecture and loss function suitable for depth estimation, we are also the first to process incomplete training data to obtain more dense and uniform prediction results. Experiments on the multi‐vehicle stereo event camera dataset show that our EAGAN is competitive on the depth estimation task and achieves the state‐of‐the‐art effect in the optical flow estimation task.
Measured behaviour of a memristor‐based tuneable instrumentation amplifier
Authors: Yang Fan , Serb Alexander , Prodromakis Themis 
Published: June 2022

AbstractA memristor‐based tuneable instrumentation amplifier whose gain value can be adjusted by memristor is implemented and measured. While memristive devices are suitable for implementing reconfigurable circuit designs, their non‐linear characteristic and parasitic capacitance can impact performance. In this work, an instrumentation amplifier is built on breadboard using off‐the‐shelf OpAmps and packaged memristor devices and its performance is assessed. Results are compared with an identical design that preplaces memristors with resistors (losing reconfigurability in the process), to reveal the effects arising from the memristor's characteristics. Effects on frequency response, common mode rejection ratio (CMRR) and total harmonic distortion plus noise (THD+N) are observed. The memristor‐based instrumentation amplifier begins to be affected by the non‐linearity of the device only when the base OpAmps have a THD value below 0.3%. The bandwidth of the instrumentation amplifier is limited by the parasitic capacitance of memristors, and CMRR has small variation when using memristor to replace the original gain resistor. The THD+N value is large compared with identical design, but it is also found that by applying multiple memristors the increasing of THD+N can be relieved.
Designing HVDC GIS/GIL spacer to suppress charge accumulation
Authors: Liang Zuodong , Lin Chuanjie , Liang Fangwei , Zhuang Weijian , Xu Yujia , Tang Lingling , Zeng Yulin , Hu Jun , Zhang Bo , Li Chuanyang , He Jinliang 
Published: June 2022

AbstractTo suppress the charge accumulation on the spacer surface in direct current (DC) gas insulated transmission line (GIL) is an important and emergent issue for the development of a clean, safe and economic smart grid. A design method of the DC spacer is proposed, and a spacer prototype is prepared and evaluated both by simulation and type test. The DC withstand voltage test and polarity reversal test are performed using the new DC spacer compared with a commercialised 220 kV AC spacer. The simulation results indicate that the surface electric field and surface charge of the DC spacer are lower than those of the alternating current (AC) spacer under DC voltage. The test results verify that the surface flashover voltage of this DC spacer is higher than that of the AC spacer. The potential feasibility of the spacer design for HVDC is discussed. It is hoped that the content of this paper can bring new ideas in the development of HVDC gas insulated equipment.
Tibial tuberosity osteotomy and medial patellofemoral ligament reconstruction for patella dislocation following total knee arthroplasty: A double fixation technique
Authors: Shatrov Jobe , Colas Antoine , Fournier Gaspard , Batailler Cécile , Servien Elvire , Lustig Sébastien 
Published: June 2022

Introduction: Patella instability post total knee arthroplasty (TKA) is a rare complication. Tibial tubercle osteotomy (TTO) with medial patellofemoral ligament reconstruction (MPFLr) has not been well described for this indication. This paper describes a surgical technique to address the unique challenges faced when performing TTO and MPFLr in the prosthetic knee. Technique: This technique and video describe a TTO and MPFLr via an extensile incision and medial sub-vastus approach. A 6 cm long TTO is performed, if indicated, to medialise the extensor mechanism up to 1 cm and fixed with ×2 4.5 mm cortical screws. For the MPFLr, a quadriceps tendon autograft is utilized, with the natural insertion to the superior pole of the patella being left undisturbed. The graft is first attached with an interference screw and then reinforced with an endobutton to provide crucial cortical fixation to overcome the problem of low bone mineral density encountered in this area of the femur following TKA. Results: Five patients underwent MPFLr using the described technique. No failures or recurrence of instability occurred at the last follow-up. Pre-operative mean patella tilt and shift were 44° and 3.5 cm, respectively. Post-operatively, mean tilt and shift were 4.1° and 0.4 cm, respectively. There was one wound dehiscence requiring surgical debridement and closure. Conclusion: This paper describes a surgical technique to perform a TTO and MPFLr for patella instability post-TKA. The described method highlights key adaptations to address the unique challenges in this patient population.
The role of suprascapular nerve block in hydrodilatation for frozen shoulder
Authors: Albana Rifki , Prasetia Renaldi , Primadhi Andri , Rahim Agus Hadian , Ismiarto Yoyos Dias , Rasyid Hermawan Nagar 
Published: June 2022

Introduction: Frozen shoulder is a debilitating problem that requires comprehensive diagnosis and management. Patients usually recover, but the possibility of not reobtaining a full range of motion exists. Thus, early shoulder exercises are necessary to achieve their full range of motion. This study aims to understand the effects of suprascapular nerve block (SSNB) augmentation at the spinoglenoid notch in hydrodilatation to treat frozen shoulder to facilitate early shoulder exercises. Methods: The current study retrospectively observed 31 patients, including 40–60-year-old patients diagnosed and treated with primary frozen shoulder. The participants were divided into groups A (hydrodilatation) and B (hydrodilatation and the augmentation of an SSNB). Shoulder function and pain scores were assessed before, during, and after the intervention (at months 1 and 6). Results: The result of this study shows that suprascapular nerve block plays a role in decreasing pain in intraintervention (0.69 vs. 5.73; p < 0.05), month 1 of follow-up (3.44 vs. 6.40; p < 0.05), but not significant on month 6 of group A and B after intervention (5.88 vs. 7.20; p > 0.05). Better delta functional scores were noted in the therapy group during month 1 of the follow-up (delta American shoulder and elbow surgeons [ASES]: 19.29 vs. 34.40, p < 0.05; delta disabilities of the arm, shoulder, and hand [DASH]: 17.88 vs. 38.15, p < 0.05). The difference in functional score on month 6 between both groups was not significantly different (delta ASES: 31.97 vs. 30.31, p > 0.05; delta DASH: 36.63 vs. 38.92, p > 0.05). Discussion: One rationale for using an SSNB augmentation at spinoglenoid notch in hydrodilatation for treating frozen shoulder was to obtain pain relief immediately to facilitate early manual exercise. SSNB has positive effects on short-term evaluation of shoulder pain and function after glenohumeral hydrodilatation, but not in the long term.