bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor-Faktor yang mempengaruhi Kinerja Kepala dan Kinerja Aparatur SOPD dan Kepuasan Pelayanan Publik
Authors: Tawalo Yusuf 
Published: July 2022

This research employed a sampling technique with a proportional stratified random sampling technique. The analysis method used was descriptive and verivicative methods, beginning with questionnaire spread, data collection, presentation, and analysis, hypothesis test, discussion and finally the making of conclusion and suggestion.
The findings of research showed the total of direct and indirect influences of the variables: Education and Training, Managerial Capacity, Occupational Sphere, Entrepreneurship Spirit, Technology Mastering and Informasi on the performance of SOPD head was 73.23 per cent. Meanwhile, the influence of SOPD head’s performance on the employees’ performance was 80.40 per cent. And the extent of the influence of employees’ performance on the satisfaction of public service was 88.30 per cent. The conclusion of the research findings was that the performance of SOPD head was not optimal, so that the performance of the employees was equally not optimal, hence it could not convey satisfaction of service to public maximally.
The Influence of Explicit Instruction Learning Model toward 11th Grade Student’s Learning Outcomes
Authors: Sahade Sahade , Amsa Yunita Susan 
Published: July 2022

This research aims to determine the influence of explicit instriction learning model toward 11th grade student‟s learning outcomes in accounting subjects at SMA Negeri 16 Makassar. The Variables in this research are explicit instriction learning model (X) and learning outcomes (Y). The population is the entire students of XI IPS clas at SMA Negeri 16 Makassar school 2016/2017 that consist of 147 students, while the sample determination uses purposive sampling technique with the number of sample is 36 students, technique of data collection used are test and observation. Technique of data analysis was done by using analysis of data validity and statistic analysis of SPSS 22 for windows. Based on the results of data analysis simple linear regression Y= -0.162+0,861X, where in every addition of one value of lerning model „explicit instruction‟, the lerning result incrased to 2.247. The mean score of pretest was 52 and posttest was 88.083 from the correlation coefficient of 0.247. Based on the t-test analysis, it was found that the tcalculation was 5.515 which was bigger than ttable 2.000. The R2 (R Square value was 0.247. The t-test result showed significant increase after treatment.
Investigation Purchase Decision Through Brand Trust, Brand Image. Price. Quality of Product: A perspective Service Dominant Logic Theory
Authors: Juliana Juliana , Pramono Rudy , Maleachi Sandra , Bernarto Innocentius , Djakasaputra Arifin 
Published: July 2022

Logically, service dominant logic tends to be more integrative than goods dominant logic. This is related to the basic proposition related to co-creation which involves active customer involvement and interaction with suppliers in every aspect of product consumption and product design. This study aimed to analyze the factors that might affect the purchasing decision of Hotpot Haidilao restaurant. This study used five variables which are brand trust, brand image, price, quality og product, purchase decision.The phenomenon of the growing food service business in the city Jakarta, which also influences consumer purchasing decisions, especially on the selection of a place to eat is the background of this study. In specifically, this research was conducted by developing a model foranalyze consumer purchasing decisions for food products and drinks at the restaurant. The sampling technique used convenience sampling with 300 respondents. Data collection techniques using googleform. The data analysis technique used is PLS-SEM. The results of the analysis conclude the purchase decision of Hotpot Haidilao restaurant was affected by brand image, brand trust, quality of product and price.
Extended-Release Viloxazine for Children and Adolescents With Attention Deficit Hyperactivity Disorder
Authors: Mather Keith , Condren Michelle 
Published: July 2022

Non-stimulant medication therapy for children, adolescents, and young adults with attention-deficit/hyperactivity disorder (ADHD) has included alpha 2-agonists (guanfacine and clonidine) as well as a norepinephrine reuptake inhibitor (atomoxetine) for multiple years. Although these may be effective options for some children, they are generally considered to be less effective than stimulant medications. In addition, there has been a suicidal ideation concern in early-late adolescence with atomoxetine, emphasizing the need for continued development of other treatment options.
Extended-release viloxazine (SPN-812) has been shown in phase 2 and phase 3 trials to be an effective, well-tolerated alternative for some children with ADHD. The mechanism of action of viloxazine is unique, modulating activity of both serotonin and norepinephrine. Treatment-related adverse events most commonly seen included somnolence, decreased appetite, and headache. Although continued evaluation to confirm the reduced symptoms of ADHD in children along with the safety profile is needed, extended-release viloxazine may offer a once-a-day pharmaceutical treatment option for patients in which stimulant medication is not effective or not a favorable option. It may also be beneficial for those children and adolescents with a comorbidity of depression.
Targeting Calcineurin Inhibitor–Induced Arterial Hypertension in Liver Transplanted Children Using Hydrochlorothiazide
Authors: Hartleif Steffen , Baier Hannah , Kumpf Matthias , Handgretinger Rupert , Königsrainer Alfred , Nadalin Silvio , Sturm Ekkehard 
Published: July 2022

OBJECTIVE
Arterial hypertension (AH) is the most common toxic effect of calcineurin inhibitor (CNI)–based immunosuppression in children after liver transplantation (LT). Activation of the renal sodium chloride cotransporter (NCC) by CNIs has been described as a major cause of CNI-induced AH. Thiazides, for example, hydrochlorothiazide (HCTZ), can selectively block the NCC and may ameliorate CNI-induced AH after pediatric LT.

METHODS
From 2005 thru 2015 we conducted a retrospective, single-center analysis of blood pressure in 2 pediatric cohorts (each n = 33) with or without HCTZ in their first year after LT. All patients received CNI-based immunosuppression. According to AAP guidelines, AH was defined as stage 1 and stage 2. Cohort 1 received an HCTZ-containing regimen to target the CNI-induced effect on the NCC, leading to AH. Cohort 2 received standard antihypertensive therapy without HCTZ.

RESULTS
In children who have undergone LT and been treated with CNI, AH overall was observed less frequently in cohort 1 vs cohort 2 (31% vs 44%; ns). Moreover, severe AH (stage 2) was significantly lower in cohort 1 vs 2 (1% vs 18%; p &lt; 0.001). Multivariate analysis revealed HCTZ as the only significant factor with a protective effect on occurrence of severe stage 2 AH. While monitoring safety and tolerability, mild asymptomatic hypokalemia was the only adverse effect observed more frequently in cohort 1 vs 2 (27% vs 3%; p = 0.013).

CONCLUSIONS
Targeting NCC by HCTZ significantly improved control of severe CNI-induced AH and was well tolerated in children who underwent LT. This effect may reduce the risk of long-term end-organ damage and improve quality of life.
Pediatric Sedation and Analgesia Outside the Operating Room: Combining Intranasal Fentanyl and Inhaled Nitrous Oxide
Authors: Hoeffe Julia , Vogel Regina G. , Ammann Roland A. 
Published: July 2022

OBJECTIVECombining intranasal fentanyl (IN FENT) with inhaled nitrous oxide (N2O) seems to have good properties for pediatric procedural sedation and analgesia (PSA). This study aims to assess the side effect rate of the combined use of IN FENT and N2O.METHODSWe performed a retrospective, single-center study. Patients treated in either the pediatric emergency department (PED) or the pediatric surgery outpatient clinic (PSOC) were included, if they received PSA with IN FENT and nitrous oxide with 50% oxygen (N2O 50%).RESULTSThree hundred seventy-five patients were included over a period of 4 years. Median age was 9.4 years (range, 3.1 to 15.9) and 39% of patients were female. Overall side effect rate was 30% (114 patients). Most frequent was dizziness (n = 63, 17%; 95% CI, 13–21), followed by nausea (n = 23, 6%; 95% CI, 4–9) and emesis (n = 14, 4%; 95% CI, 2–6), with 35 patients having either nausea and/or emesis (9%; 95% CI, 7–13). No serious side effects were recorded (0%; 95% CI, 0–0.1). Of 298 patients with information regarding satisfaction, 280 patients would like the same sedation for a similar procedure in the future (94%; 95% CI, 90–96). We found no relation between previously described risk factors and emesis and/or nausea.CONCLUSIONSN2O 50% combined with IN FENT can be recommended as an effective and safe treatment in the PED and the PSOC. While the side effect rate, primarily dizziness, nausea and emesis was substantial, antiemetic prophylaxis is not indicated owing to the overall low incidence of nausea and emesis.
Admission Medication Reconciliations in Pediatric Patients Admitted to an Inpatient Psychiatry Unit
Authors: Van Nguyen Anh , Romanowski Gale , Ley Michael , Lim Emily , McFarland Kaitlin , Morrison Tyler 
Published: July 2022

OBJECTIVE
Medication errors resulting in adverse drug events may occur during transition of care. Most can be prevented with a medication reconciliation. California Senate Bill 1254 requires a pharmacist to perform an admission medication reconciliation (AMR) to obtain an accurate medication list for each high-risk patient upon hospital admission. Adult patient literature reveals that antidepressant, antipsychotic, and mood-stabilizing drugs are high-risk medications likely to cause errors. Therefore, the purpose of this analysis is to determine if pediatric psychiatry inpatients should be considered high risk, meriting an additional AMR by the pharmacy team.

METHODS
This was a retrospective, single-center analysis of pediatric patients admitted to the inpatient psychiatry unit at Rady Children's Hospital, San Diego between January 1 and 31, 2021. All newly admitted patients had an AMR performed by the medical team (physician-led AMR). High-risk patients (prescribed a high-risk medication or 3 or more medications of any kind prior to admission) had an additional AMR by the pharmacy team (pharmacy-led AMR). Differences between these 2 AMRs were examined.

RESULTS
Of the 58 patients admitted during the study period, 39 (67.2%) were identified as high risk, warranting an AMR by the pharmacy team. From the 170 medications reviewed, 51 differences (30%) were found between physician-led and pharmacy-led AMR, with 4 (2.4%) of the differences involving high-risk medications. No medications were incorrectly ordered, and no adverse drug events occurred.

CONCLUSIONS
Given that physician-led and pharmacy-led AMRs of high-risk prescription medications were only marginally different and no medications were incorrectly ordered, the existing AMR methodology used by psychiatrists at our institution is effective at creating a safe medication list.
Evaluation of Sirolimus Dosing in Neonates and Infants With Lymphatic Disorders: A Case Series
Authors: Serio Jordan , Gattoline Sarah , Collier Hailey , Bustin Anna 
Published: July 2022

OBJECTIVE
Literature in pediatric patients suggests dosing sirolimus 1.6 mg/m2/day divided twice daily for lymphatic disorders with limited evidence available for dosing in neonates and infants. The objective of this research was to determine the sirolimus dose required to achieve therapeutic trough concentrations in infants with lymphatic disorders at Children's Hospital of Philadelphia.

METHODS
This retrospective review included patients &lt;1 year of age at Children's Hospital of Philadelphia who were initiated on sirolimus for lymphatic disorder. Patients were included if they received at least 5 days of consecutive sirolimus therapy prior to trough concentration monitoring. Measures of central tendency and variability were used for statistical analysis.

RESULTS
A total of 16 patients met criteria for inclusion. The median initial sirolimus dose was 1 mg/m2/day (IQR, 0.5–1.6 mg/m2/day). Fourteen patients (87.5%) achieved therapeutic trough concentrations on a median sirolimus dose of 0.5 mg/m2/day. Dosing frequency to achieve therapeutic trough concentrations included 1 patient (6.25%) on twice daily dosing, 12 patients (75%) on once daily dosing, and 1 patient (6.25%) requiring every 48-hour dosing. The median time to first therapeutic trough was 15.5 days (IQR, 5.5–18.5 days), and patients required a median of 1 dose adjustment.

CONCLUSIONS
A median sirolimus dose to achieve therapeutic sirolimus trough concentrations in infants with lymphatic disorders was 0.5 mg/m2/day with a median of 1 dose adjustment. Sirolimus was well tolerated in the study population.
When There Is No Trough: Use and Outcomes of Continuous-Infusion Vancomycin at a Free-Standing Children's Hospital
Authors: Wysocki Emma , Tansmore Jessica 
Published: July 2022

OBJECTIVE
There is minimal published literature regarding the use of continuous-infusion vancomycin (CIV) in children. The objective of this study was to describe the use, dosing requirements, and outcomes of CIV at a free-standing children's hospital.

METHODS
This is a retrospective review of patients who received CIV while admitted to Nationwide Children's Hospital between July 1, 2010, and June 30, 2020. The total daily dose (TDD) of vancomycin required to attain a target serum vancomycin concentration (SVC) was compared between CIV and intermittent-infusion vancomycin (IIV) administration regimens. Safety outcomes and treatment failure were also explored.

RESULTS
Fourteen patients (77% male) with a median age of 7 years (IQR = 1, 10 years) were included. Most patients (71%) were started on CIV in anticipation of outpatient parenteral antimicrobial therapy. The median TDD required to achieve a target SVC was higher with IIV compared with CIV (82.4 mg/kg/day vs 50.5 mg/kg/day; p = 0.02). Despite higher TDD with IIV, median SVC with IIV was similar to SVC with CIV (16.6 mg/L vs 17.6 mg/L; p = 2.00). There were no safety concerns or therapeutic failures identified with CIV.

CONCLUSIONS
Continuous-infusion vancomycin was a well-tolerated and effective alternative to IIV for the patients included in this study. The TDD of vancomycin required to achieve a target SVC was lower in patients receiving CIV compared with those receiving IIV.
A Survey from a Tertiary Care Hospital in India on Pediatric Medication Re-Dosing Practices After Patient Vomiting
Authors: Thangaraju Pugazhenthan , Natha Jondhale Sunil , Venkatesan Sajitha , Tanguturi Yella Sree Sudha 
Published: July 2022

OBJECTIVE
The study was started in our institution to analyze the clinical problem and identify the benefits and drawbacks of current practices associated with drug re-dosing after vomitting. Opinions and perspectives from health care professionals from various pediatric hospitals were also gathered to build an effective and systematic protocol.

METHODS
Survey participants were recruited by using email distribution lists and forums catering to health care. Using this, 2 online surveys were carried out in the window period of 6 months.

RESULTS
Of the 14 responses from the study hospitals that were suitable for analysis, 64.2% reported pediatric patients that vomited after being administered oral medications: 7.1% faced this daily, 35.7% weekly, and 21.4% monthly. When respondents were asked to rate the importance of 8 factors potentially affecting the decision to re-dose, more than half indicated that the patient's vitals and condition (stable, unstable, or critical) were most important (57.4%), followed by time after ingestion (50%), familiarity with medication (42.8%), and formulation of medication (42.8%). Of 43 respondents from other institutions, only 11.9% had a functioning guideline for re-dosing in their institution.

CONCLUSIONS
Health care professional respondents to our surveys listed the time between ingestion and vomiting and the condition of the patient as the most important factors in their decision to re-dose the medication.
Formação Continuada de Professores da Educação de Jovens e Adultos e Práxis Pedagógica: uma reflexão na perspectiva humanizadora e libertadora da educação
Authors: Oliveira Adriana Bastos , Silva Eduardo Jorge Lopes da , Alencar Maria Fernanda dos Santos 
Published: July 2022

Este ensaio teórico de análise bibliográfica trata sobre a formação continuada de professores para a Educação de Jovens e Adultos (EJA). Apresenta reflexões sobre a formação de professores e práxis pedagógica para os professores da EJA, numa perspectiva humanizadora e libertadora de educação. Neste sentido, constatou-se que: 1) a formação continuada de professores deveria ocorrer no próprio espaço da escola, balizada pelas realidades e tendo, por parte da academia e demais formadores, o reconhecimento dos saberes docentes num diálogo contínuo e formativo com aqueles que fazem a educação no chão das escolas 2) a formação continuada de professores, em destaque para o professor da EJA e a sua práxis pedagógica, deveria envolver a pesquisa/intervenção da/na realidade complexa do cotidiano escolar, com foco no compromisso político, nos valores éticos e morais favorecendo o desenvolvimento integral desse profissional da educação.
The global crisis is a crisis of civilization: a political ecology perspective
Authors: Toledo Víctor M. 
Published: July 2022

Inspired by the intellectual currents of political ecology, this essay aims to shed light on the crisis of the contemporary world. The social sciences, or plain science, require a profound and urgent renewal in order to highlight the hegemonic structures of knowledge; Over-specialized studies, so common in recent decades, are barely capable of capturing fragments or pieces of reality, overlooking or ignoring the political power relations closely linked to the world they seek to study. It is clear that a radical transformation is required in all areas of social life and the first step is to accept that we are not facing a simple economic, technological or cultural change, but rather a transformation of human civilization.
Inspirado en las corrientes intelectuales de la ecología política, este ensayo pretende arrojar luz sobre la crisis del mundo contemporáneo. Las ciencias sociales, o la ciencia a secas, requieren una profunda y urgente renovación con el fin de poner de relie-ve las estructuras hegemónicas del conocimiento; los estudios sobreespecializados, tan comunes en las últimas décadas, apenas son capaces de capturar fragmentos o pedazos de la realidad pasando por alto o ignorando las relaciones de poder políticas estrecha-mente vinculadas con el mundo que pretenden estudiar. Es evidente que se requiere una transformación radical en todos los ámbitos de la vida social y el primer paso es aceptar que no estamos ante un simple cambio económico, tecnológico o cultural, sino ante una transformación de la civilización humana.
Maternal experiences of care following a stillbirth at Steve Biko Academic Hospital, Pretoria, South Africa
Authors: Jimoh A S , Wolvaardt J E , Adams S 
Published: July 2022

Background. Despite improvements in obstetrics and neonatal care, the stillbirth rate remains high (23 per 1 000 births) in South Africa (SA). The occurrence of a stillbirth is a dramatic and often life-changing event for the family involved. The potential consequences include adverse effects on the health of the mother, strain on the relationship of the parents, and strain on the relationship between the parents and their other children. The standard of care in SA follows the Royal College of Obstetricians and Gynaecologists Green-top guidelines.Objectives. To explore maternal experiences of in-patient care received in cases of stillbirth.Methods. A descriptive phenomenological approach was performed in the obstetrics unit at Steve Biko Academic Hospital, Pretoria, SA. Post-discharge interviews were conducted with women who experienced a stillbirth. The healthcare workers in the obstetric unit were also interviewed on the care provided to these patients. Data analysis was performed using the Colaizzi’s method.Results. Data from the interviews with the 30 patients resulted in five themes relating to the maternal experience of stillbirth: ‘broken heart', ‘helping hand’, ‘searching brain’, ‘soul of service’ and ‘fractured system’. Healthcare worker participants emphasised the importance of medical care (the clinical guidelines) rather than maternal care (the psychosocial guidelines).Conclusion. While the medical aspects of the guidelines are adhered to, the psychosocial aspects are not. Consequently, the guidelines require adaptation, especially taking into consideration African cultural practices, and the inclusion of allocated responsibility regarding the application of the psychosocial guidelines, as this is the humanitarian umbilical cord between healthcare workers and those in their care.
Bleeding and thrombosis outcomes in hospitalised COVID-19 patients on low-molecular-weight heparin and antiplatelet therapy
Authors: Pillay-Fuentes Lorente V , Van Rensburg R , Moolla M S , McCaul M , Parker A , Taljaard J , Reuter H , Decloedt E H 
Published: July 2022

Background. An increased incidence of thromboembolic events in hospitalised COVID‐19 patients has been demonstrated despite the use of low‐molecular‐weight heparin (LMWH). Antiplatelet therapy prior to admission and early in the disease course has been hypothesised to be protective against thrombosis.Objectives. To describe the bleeding and thrombosis outcomes in hospitalised patients with confirmed COVID‐19 receiving LMWH, with and without concomitant antiplatelet therapy. Secondary objectives were to explore predictors of bleeding and thrombosis outcomes, and dosing practices of antiplatelet therapy and LMWH.
Methods. We conducted a descriptive, cross‐sectional study of bleeding and thrombosis outcomes at Tygerberg Academic Hospital, Cape Town, South Africa, during the first COVID‐19 wave, in 808 hospitalised patients with confirmed COVID‐19 receiving LMWH with and without concomitant antiplatelet therapy. Multivariate logistic regression analysis was performed if predictors were deemed statistically and clinically significant.
Results. Patients receiving both LMWH and antiplatelet therapy had similar bleeding outcomes compared with patients only receiving LMWH (odds ratio (OR) 1.5; 95% confidence interval (CI) 0.6 ‐ 4.0). Patients receiving both LMWH and antiplatelet therapy had increased odds of developing thrombosis compared with patients only receiving LMWH (OR 4.8; 95% CI 2.1 ‐ 10.7).Conclusion. The bleeding risk in COVID‐19 patients receiving both LMWH and antiplatelet therapy was not significantly increased. A potentially higher risk of thrombosis in patients receiving LMWH and antiplatelet therapy was observed. However, this could reflect confounding by indication. Randomised studies are required to further evaluate the use of antiplatelet therapy to treat hospitalised patients with COVID‐19.