bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of transcranial direct current stimulation on eye movements and associated psychological function
Authors: Subramaniam Ashwin , Liu Sicong , Lochhead Liam , Appelbaum Lawrence Gregory 
Published: October 2022

Abstract
The last decades have seen a rise in the use of transcranial direct current stimulation (tDCS) approaches to modulate brain activity and associated behavior. Concurrently, eye tracking (ET) technology has improved to allow more precise quantitative measurement of gaze behavior, offering a window into the mechanisms of vision and cognition. When combined, tDCS and ET provide a powerful system to probe brain function and measure the impact on visual function, leading to an increasing number of studies that utilize these techniques together. The current pre-registered, systematic review seeks to describe the literature that integrates these approaches with the goal of changing brain activity with tDCS and measuring associated changes in eye movements with ET. The literature search identified 26 articles that combined ET and tDCS in a probe-and-measure model and are systematically reviewed here. All studies implemented controlled interventional designs to address topics related to oculomotor control, cognitive processing, emotion regulation, or cravings in healthy volunteers and patient populations. Across these studies, active stimulation typically led to changes in the number, duration, and timing of fixations compared to control stimulation. Notably, half the studies addressed emotion regulation, each showing hypothesized effects of tDCS on ET metrics, while tDCS targeting the frontal cortex was widely used and also generally produced expected modulation of ET. This review reveals promising evidence of the impact of tDCS on eye movements and associated psychological function, offering a framework for effective designs with recommendations for future studies.
Acacetin improves cognitive function of APP/PS1 Alzheimer’s disease model mice via the NLRP3 inflammasome signaling pathway
Authors: Bu Juan , Zhang Yanmin , Mahan Yeledan , Shi Shen , Wu Xuanxia , Zhang Xiaoling , Wang Zhaoxia , Zhou Ling 
Published: October 2022

Abstract

Background
Acacetin (5,7-dihydroxy-4′-methoxyflavone), one of the main extractions from Saussurea involucrata, has anti-inflammatory effects. Our previous study found that acacetin inhibited the Nod-like receptor pyrin domain containing 3 (NLRP3) signaling pathway after cerebral ischemia–reperfusion injury. NLRP3 inflammasome plays a role in Alzheimer’s disease (AD) process. However, few studies have examined the effects of acacetin in AD.

Methods
We randomly divided APP swe/PS1dE9 double transgenic mice into acacetin group (intraperitoneal injection of 25 mg/kg acacetin) and AD model group (intraperitoneal injection of same volume of saline). C57BL/6 mice were selected as control group (same treatment with AD model group). After treating for 30 days, a Morris water maze test was conducted to evaluate spatial learning and memory of the mice. Senile plaque (SP) formation was evaluated by immunohistochemistry. NLRP3 inflammasome-related inflammatory factors and amyloid-β-42 were detected by Western blot or enzyme-linked immunosorbent assay.

Results
Acacetin improved spatial learning and memory of AD mice and reduced APP/β expression, thereby decreasing SP formation in the brain. Acacetin also reduced the expression of NLRP3, cysteinyl aspartate-specific proteinase 1 (caspase-1), and interleukin-1β (IL-1β) and the release of inflammatory factors, tumor necrosis factor-α (TNF-α) and IL-1β.

Conclusions
Acacetin improved the learning and memory abilities of AD mice and exerted a protective effect on AD by inhibiting the NLRP3 signaling pathway and reducing SP formation.
Evaluation of diethylenetriaminepentaacetic acid modified chitosan immobilized in amino-carbmated alginate matrix as a low cost adsorbent for effective Cu(II) recovery
Authors: Shehzad Hamza , Farooqi Zahoor H. , Ahmad Ejaz , Sharif Ahsan , Irfan Ahmad , Din Muhammad Imran , Begum Robina , Liu Zhirong , Zhou Limin , Ouyang Jinbo , Rasheed Lubna , Akram Tehreem , Mahmood Azhar 
Published: October 2022

Abstract
In present work, facile synthesis of a biocompatible hybrid biosorbent based on diethylenetriaminepentaacetic acid (DTPA) modified chitosan immobilized in organo-functionalized sodium alginate matrix (DTPA-MCSA) was carried out. DTPA-MCSA was casted in microspherical hydrogel beads. Three dimensional microporous geometry of the biosorbent remained well preserved as observed in SEM analysis which revealed the improved mechanical strength of the alginate matrix. Surface functionalization of base biopolymers was confirmed by FTIR and SEM analysis. Equilibrium sorption studies using DTPA-MCSA for Cu(II) from aqueous medium were carried out in batch mode and found considerably dependent on pH, contact sorption time, temperature and initial copper concentration. Isothermal sorption data showed close correlation with Langmuir model as evident from nonlinear fitting of data (R
2 ˜ 0.99) at different temperatures. The experimental sorption capacity (q
e) was found nearly 67 mg/g using 100 mg/L initial concentration of copper ions. Kinetic studies were conducted using different initial concentrations for better elucidation of results and it showed better correlation with pseudo second order rate equation which unveiled that strong ion pair coordination and complexation exist between Cu(II) and newly grafted chelating sites of DTPA-MCSA. Thermodynamic parameters suggested that the adsorption process is spontaneous and endothermic. The results concluded that DTPA-MCSA could be a better candidate for adsorptive remediation of copper ions from liquid waste.
The Absence of Parkin Does Not Promote Dopamine or Mitochondrial Dysfunction in PolgAD257A/D257AMitochondrial Mutator Mice
Authors: Scott Laura , Karuppagounder Senthilkumar S. , Neifert Stewart , Kang Bong Gu , Wang Hu , Dawson Valina L. , Dawson Ted M. 
Published: October 2022

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). In this study, we generated a transgenic model by crossing germline Parkin–/–mice with PolgAD257Amice, an established model of premature aging and mitochondrial stress. We hypothesized that loss of Parkin–/–in PolgAD257A/D257Amice would exacerbate mitochondrial dysfunction, leading to loss of dopamine neurons and nigral-striatal specific neurobehavioral motor dysfunction. We found that aged Parkin–/–/PolgAD257A/D257Amale and female mice exhibited severe behavioral deficits, nonspecific to the nigral-striatal pathway, with neither dopaminergic neurodegeneration nor reductions in striatal dopamine. We saw no difference in expression levels of nuclear-encoded subunits of mitochondrial markers and mitochondrial Complex I and IV activities, although we did observe substantial reductions in mitochondrial-encoded COX41I, indicating mitochondrial dysfunction as a result of PolgAD257A/D257AmtDNA mutations. Expression levels of mitophagy markers LC3I/LC3II remained unchanged between cohorts, suggesting no overt mitophagy defects. Expression levels of the parkin substrates, VDAC, NLRP3, and AIMP2 remained unchanged, suggesting no parkin dysfunction. In summary, we were unable to observe dopaminergic neurodegeneration with corresponding nigral-striatal neurobehavioral deficits, nor Parkin or mitochondrial dysfunction in Parkin–/–/PolgAD257A/D257Amice. These findings support a lack of synergism of Parkin loss on mitochondrial dysfunction in mouse models of mitochondrial deficits.SIGNIFICANCE STATEMENTProducing a mouse model of Parkinson's disease (PD) that is etiologically relevant, recapitulates clinical hallmarks, and exhibits reproducible results is crucial to understanding the underlying pathology and in developing disease-modifying therapies. Here, we show that Parkin–/–/PolgAD257A/D257Amice, a previously reported PD mouse model, fails to reproduce a Parkinsonian phenotype. We show that these mice do not display dopaminergic neurodegeneration nor nigral-striatal-dependent motor deficits. Furthermore, we report that Parkin loss does not synergize with mitochondrial dysfunction. Our results demonstrate that Parkin–/–/PolgAD257A/D257Amice are not a reliable model for PD and adds to a growing body of work demonstrating that Parkin loss does not synergize with mitochondrial dysfunction in mouse models of mitochondrial deficits.
Differential Regulation of the BDNF Gene in Cortical and Hippocampal Neurons
Authors: Esvald Eli-Eelika , Tuvikene Jürgen , Moistus Andra , Rannaste Käthy , Kõomägi Susann , Timmusk Tõnis 
Published: October 2022

Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin that supports the survival, differentiation, and signaling of various neuronal populations. Although it has been well described that expression of BDNF is strongly regulated by neuronal activity, little is known whether regulation of BDNF expression is similar in different brain regions. Here, we focused on this fundamental question using neuronal populations obtained from rat cerebral cortices and hippocampi of both sexes. First, we thoroughly characterized the role of the best-described regulators of BDNF gene - cAMP response element binding protein (CREB) family transcription factors, and show that activity-dependent BDNF expression depends more on CREB and the coactivators CREB binding protein (CBP) and CREB-regulated transcriptional coactivator 1 (CRTC1) in cortical than in hippocampal neurons. Our data also reveal an important role of CREB in the early induction of BDNF mRNA expression after neuronal activity and only modest contribution after prolonged neuronal activity. We further corroborated our findings at BDNF protein level. To determine the transcription factors regulating BDNF expression in these rat brain regions in addition to CREB family, we usedin vitroDNA pulldown assay coupled with mass spectrometry, chromatin immunoprecipitation (ChIP), and bioinformatics, and propose a number of neurodevelopmentally important transcription factors, such as FOXP1, SATB2, RAI1, BCL11A, and TCF4 as brain region-specific regulators of BDNF expression. Together, our data reveal complicated brain region-specific fine-tuning of BDNF expression.SIGNIFICANCE STATEMENTTo date, majority of the research has focused on the regulation of brain-derived neurotrophic factor (BDNF) in the brain but much less is known whether the regulation of BDNF expression is universal in different brain regions and neuronal populations. Here, we report that the best described regulators of BDNF gene from the cAMP-response element binding protein (CREB) transcription factor family have a more profound role in the activity-dependent regulation of BDNF in cortex than in hippocampus. Our results indicate a brain region-specific fine tuning of BDNF expression. Moreover, we have used unbiased determination of novel regulators of the BDNF gene and report a number of neurodevelopmentally important transcription factors as novel potential regulators of the BDNF expression.
An examination of mercury concentrations in eggshells of the common snapping turtle (Chelydra serpentina) in Nova Scotia, Canada
Authors: Taylor Jillian R. , Campbell Linda , LeBlanc Molly 
Published: October 2022

Mercury (Hg) is a potentially toxic metal that has bioaccumulating and biomagnifying properties. In egg laying animals, it can be transferred from an adult female to offspring. However, in turtles, the inter-and-intra-nest variation of Hg concentrations remains unknown. We investigated the concentration of Hg in preyed-upon Common Snapping Turtles (Chelydra serpentina) eggshells. The variability in Hg contamination between and within each nest was assessed. In June 2021, 368 eggshells left behind by predators were sampled from 14 nests, from three different sites in southwest Nova Scotia. Ten eggshells were randomly selected from each nest for analysis. We found no correlation between estimated number of eggs in a nest and average nest Hg concentration. Significant inter-nest variation (Hg ranging from 12.0 ± 3.85 to 172.3 ± 43.9 µg/kg) and intra-nest variability may indicate maternal transfer. The collection of the shells of freshly preyed- upon eggs is a useful non-destructive sampling technique to maintain sustainable turtle populations. Our results demonstrate the need for further investigation into the impact of Hg on temperate, freshwater turtle reproduction. Keywords: mercury concentration, maternal transfer, common snapping turtle, eggshells
Pola Penerapan Sanksi Administratif Bagi Perusahaan Penyedia Jasa Tenaga Kerja Indonesia Terhadap perlindungan Buruh Migran Indonesia di Luar Negeri
Authors: Herlambang Pratama Herry , Sulistiyono Tri , Risky Salsabila Masyita Isnadya 
Published: October 2022

Iming-imingi upah yang besar menjadi pekerja migran diluar neeri juga dibayangi-bayangi akan resiko yang juga sama besarnya. Jumlah perpindahan pekerja dari tanah air ke negeri asing semakin lama semakin meningkat . Resiko yang besar dan minat yang tinggi menyebabkan buruh migran sebagai pihak yang rentan terenggut haknya olehkarena itu perlu dilindungi oleh negara. Penelitian ini berusaha mengkaji mengenai penerapan pola sanksi yang didapat oleh perusahaan penyedia jasa tenaga kerja sebagai buruh migran dan perlindungan bagi buruh migran Indonesia. Penelitian dilakukan dengan menggunakan pendekatan yuridis empiris dimana realita yang terjadi dilapangan dikaji dan dikomparasi dengan ketentuan hukum yang berlaku. Tujuan untuk mengetahui seperti apa perlindungan hukum bagi pekerja migran dan sanksi bagi Penyedia Jasa Tenaga Kerja Indonesia
Reducing the Company’s Insolvency: How suspension of debt payment obligation and bankruptcy proceedings help the company?
Authors: Agasie Deyola , Apriani Rani 
Published: October 2022

Corporate insolvency will have an unfavorable effect on the country's economy. Currently many companies are facing the threat of bankruptcy applications in the Commercial Court because difficulty of paying the company's debts to its creditors. In the midst of the situation the number of Covid-19 cases that occurred in Indonesia, it has a negative impact with the decline in the performance of business actors due to the crisis. From that situation, it results in a decrease in the amount of income to the difficulty of paying debts or credit to creditors. To reduce the increase in insolvency, the government seeks the enactment of a moratorium on PKPU and Bankruptcy whose implementation will pay attention to the development of Covid-19 pandemic conditions. This research aims to find out how the implications in implementing a moratorium on PKPU and Bankruptcy in order to reduce the company's insolvency and how its legal protection efforts for creditors and debtors. This research is Normative juridical with a Statute Approach. The results of this study are the implications that will occur in the enactment of the moratorium on PKPU and Bankruptcy and legal protection for the parties under Law No. 37 of 2004 on Bankruptcy and Delay of Debt Payment Obligations. By fulfilling the terms and conditions as intended, the conclusion obtained is that the implementation of the moratorium has a positive and negative impact on the parties and obtains protection and is justified by applicable law but must be in accordance with the applicable provisions.
MAKNA VERBA MEMASAK BAHASA BANJAR: KAJIAN METABAHASA SEMANTIK ALAMI
Authors: Wulandari Zindi Nadya , Subiyanto Agus 
Published: October 2022

Abstract: The purpose of this study is to find the meaning of the verb cooking in Banjarese. The data in this study were obtained through interviews with native speakers of the Banjarese. The researcher did the interviews which followed by the note-taking technique in collecting the data. Then, the researcher used the theory of Natural Semantic Metalanguage (MSA) by Wierzbicka (1996) to analyze the data. The result of the data analysis shows that cooking in Banjarese consists of 13 lexicons, which are categorized based on cooking techniques, facilities and tools used. The 13 lexicons of cooking verbs in Banjarese are tumis, oseng, jarang, sangging, gangan, sumap, tumpi, tu'up, pais, banam, ubar, samgrai, sanga. Keywords: Banjarese; Natural Semantic Metalanguage; Cooking Verb Abstrak: Penelitian ini merupakan penelitian kualitatif dengan tujuan untuk untuk mengungkapkan makna yang ada dalam verba memasak dalam bahasa Banjar. Data dalam penelitian ini diperoleh melalui wawancara dengan penutur asli bahasa Banjar. Dalam mengumpulkan data, peneliti melakukan wawancara yang dilanjutkan dengan teknik catat yang digunakan untuk mencatat jawaban dari informan Kemudian, peneliti menggunakan teori Metabahasa Semantik Alami (MSA) oleh Wierzbicka (1996). Hasil dari analisis data menunjukkan bahwa memasak dalam bahasa Banjar terdiri atas 13 leksikon, yang dikategorikan berdasarkan teknik memasak, sarana dan alat yang digunakan. 13 leksikon verba memasak dalam bahasa Banjar antara lain tumis, oseng, jarang, sangging, gangan, sumap, tumpi, tu’up, pais, banam, ubar, sangrai, sanga. Kata Kunci: Bahasa Banjar; Metabahasa Semantik Alami; Verba Memasak
Ampliación en la distribución biogeográfica de la familia Pleidae (Hemiptera: Nepomorpha) en Colombia
Authors: Bernal Z. Jeny Tatiana , Llano A. Camilo Andrés , Morales Irina , Gomes Dias Lucimar 
Published: October 2022

La familia Pleidae se encuentra distribuida mundialmente y comprende cuatro géneros, alrededor de 38 especies y una subespecie. En Suramérica, se encuentra representada por tres géneros: Neoplea, Paraplea y Heteroplea. En Colombia están documentados los dos primeros, pero aún es incipiente el conocimiento de su distribución en el territorio nacional. Objetivo. Ampliar el conocimiento de Pleidae en Colombia, mediante el reporte de nuevos registros geográficos. Metodología. Se revisó material entomológico de diferentes proyectos de investigación depositados en la Colección Entomológica del Programa de Biología de la Universidad de Caldas (CEBUC) y se realizó un levantamiento de la información secundaria con registros de Pleidae para Colombia. Resultados. Como resultado se registra por primera vez el género Neoplea para los departamentos de Caldas y Tolima, además se amplía sudistribución en el departamento de Córdoba. En este trabajo se reportan dos especies: N. maculosa y N. semipicta, la primera registrada solamente en Córdoba y la segunda en los tres departamentos mencionados. Conclusión. Este trabajo amplía el conocimiento de los Pleidae de Colombia y también resalta la importancia de las colecciones biológicas.
Directores escolares ante el síndrome de burnout: dimensiones, factores de riesgo y sintomatología
Authors: Sanz Ponce Roberto , Morales Yago Francisco , González Bertolín Aurelio 
Published: October 2022

La Dirección es fundamental para mejorar la calidad de la educación. Estudios, nacionales e internacionales, sitúan al Director como figura clave para el cambio educativo. Pero, este colectivo se encuentra sometido a mucho estrés asociado a problemáticas de liderazgo y de organización escolar, lo que conlleva malestar y falta de compromiso. Por ello, se marca como objetivo medir las dimensiones que definen el síndrome de burnout e identificar los factores de riesgo y la sintomatología que presentan los Directores. Se utilizó una metodología cuantitativa, mediante el pase del Cuestionario TALIS para Directores, a una muestra de 76 Directores de centros concertados de la ciudad de Valencia. Los análisis realizados son de carácter univariado y bivariado. En cuanto a los resultados, se presentan algunos indicadores asociados al Cansancio emocional, la Despersonalización y la Dificultad parael logro/realización personal, aunque mayoritariamente señalan altas valoraciones hacia el ejercicio directivo y bajos niveles de burnout en términos generales. También se evidenció la necesidad de incrementar la formación específica en liderazgo pedagógico, compartido y transformativo. Se observó, además, la necesidad de potenciar las habilidades directivas para implementar unas correctas relaciones con compañeros y familias. Las variables sexo, experiencia e incentivos no muestran diferencias significativas, por el contrario, la edad y el apoyo de los superiores sí presentan diferencias. Como conclusión, estos resultados van en la línea de otras investigaciones, proponiéndose mejoras en la profesionalización directiva, para acrecentar la calidad y la permanencia en las responsabilidades asumidas ante la eficiente gestión de la dirección escolar.
Percepción futura del humedal “el culebrón”, Coquimbo (Chile) : una experiencia educativa interdisciplinaria.
Authors: Araya Piñones Angelo , Salas Bravo Sonia , Campos Castillo Cecilia 
Published: October 2022

Los humedales representan una transición entre un ambiente terrestre y acuático, constituyéndose como uno de los sistemas naturales más importantes debido a sus múltiples funciones; no obstante, a pesar de su importancia, representan uno de los ecosistemas más vulnerables. Los humedales de la costa de la región de Coquimbo-Chile configuran un sistema dinámico con gran presencia de biodiversidad en un área con predominio semi-árido. En este contexto, resulta importante acercarse a un mayor conocimiento de estos sistemas con el fin de promover su conservación y/o restauración, siendo una fundamental herramienta las experiencias educativas. Objetivo. Determinar cómo es percibido el futuro del humedal “El Culebrón” por estudiantes de enseñanza media a través del desarrollo de escenarios cualitativos. Materiales y métodos. Se generó inicialmente un conjunto de escenarios a partir de una proyección de 10 años, los cuales fueron reinterpretados mediante el software NVIVO9. Resultados. El análisis permitió diferenciar cuatro escenarios: “responsabilidad social”, “cambio climático”, “crecimiento de lo natural” y “urbanización”. Conclusiones. Se puede inferir un futuro amenazante de los humedales desde la perspectiva percibida por los estudiantes debido a la interacción de impulsores de cambio indirectos, entre los que se destacan elementos naturales (cambio climático y eventos extremos) cambios demográficos (urbanización) y culturales (conciencia ambiental precaria o insuficiente).