bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoadjuvant PD-1 blockade combined with chemotherapy or chemotherapy alone for patients with resectable locally advanced esophageal carcinoma: A real-world data analysis
Authors: Cheng Daoan , Zhao Weiqing , Chen Rui , Li Dong , Tang Shuxian , Fang Cheng , Ji Mei 
Published: October 2022

Abstract
Background

Neoadjuvant concurrent chemoradiotherapy with surgery was the standard of therapy for esophageal cancer. But many patients refused or abandoned radiotherapy because of the intolerable adverse effects in China. Neoadjuvant immunochemotherapy (nICT) followed by surgery has become an emerging treatment in patients with esophageal cancer. There was still no consensus on whether neoadjuvant immunochemotherapy was superior to neoadjuvant chemotherapy (nCT) alone in patients with esophageal cancer.

Methods

In this retrospective study, patients with resectable esophageal cancer received surgery after neoadjuvant immunochemotherapy (nICT) (n = 26, 40%) or neoadjuvant chemotherapy (nCT) alone (n = 39, 60%) were included. The patients were classified as nICT or nCT arm. The primary end points were pathological tumor response (PTR) and event-free survival (EFS). The different clinic-pathological features were compared by the Kruskal-Wallis test for continuous variables and the Chi-square (χ2) test for categorical variables. Kaplan-Meier curves were used to estimate EFS from the date of treatment to recurrence or death. All tests were 2-sided with a significative P-value defined < .05.

Results

Three (11.5%) of the 26 patients achieved pathological complete remission (pCR) in the nICT group, and four (10.3%) of the 39 patients achieved pCR in the nCT group, respectively (P = 1.0). Six (23.1%) of the 26 patients achieved major pathological response (MPR) in the nICT group, and eleven (28.2%) of the 39 patients achieved MPR in the nCT group, respectively (P = 0.645). Downstaging was achieved in 13 (44.8%) patients in the nICT group and 16 (55.2%) patients in the nCT group, respectively (P = 0.732). To verify the TRG results, we compared them with MPR and pCR, which showed a significant dependency (P < 0.001). Patients who achieved downgrading showed better MPR and pCR rates (P<0.001 and P = 0.010). There was no significant difference in EFS between nICT and nCT group (HR = 1.011, 95%CI: 0.421–2.425, P = 0.981).

Conclusions
Clinical and radiographic outcomes of oblique lumbar interbody fusion with anterolateral screw and rod instrumentation in osteopenia patients: a retrospective study
Authors: Li Renjie , Liu Yijie , Zhu Yi , Lu Minhua , Jiang Weimin 
Published: October 2022

Abstract
Purpose
The purpose of this paper is to evaluate the clinical and radiographic outcomes of oblique lumbar interbody fusion to perform in L4/5 degenerative lumbar spondylolisthesis (DLS) patients who diagnosed with osteopenia.
Methods
From December 2018 to 2021 March, 90 patients were diagnosed with degenerative spondylolisthesis underwent OLIF and divided into two groups with different bone mineral density. Anterolateral screw and rod instrumentation was applied in two groups. The primary outcomes were VAS, JOA and ODI. The secondary outcomes included disc height (DH), cross-sectional height of the intervertebral foramina (CSH), cross-sectional area of the dural sac (CSA), lumbar lordorsis (LL), pelvic titlt (PT), pelvic incidence (PI) and sacrum slop (SS).
Results
All patients finished at least 1 years follow-up with 20.43 ± 4.80 months in the group A and 21.19 ± 4.68 months in the group B. The clinical symptoms were evaluated by VAS, JOA and ODI and 90 patients showed good outcomes at final follow-up (P < 0.05), with significant increases in DH, CSH and CSA. In group A, DH increased from 8.45 ± 2.28 to 10.50 ± 2.48 mm, while increased from 8.63 ± 2.15 to 10.97 ± 1.63 were recorded in group B. No statistical difference was found in DH between the two groups (P > 0.05). The cage subsidence was 1.28 ± 0.92mm in group A and 1.15 ± 0.86mm in group B (P > 0.05). There was no significant difference in the adjusted parameters of spino-pelvic between two groups (P > 0.05).
Conclusion
Oblique lumbar interbody fusion with anterolateral screw and rod instrumentation is feasible to be performed in osteopenia patients who diagnosed with degenerative spondylolisthesis.
Anatomy in the Minds of Health Sciences Undergraduates: A Metaphor Analysis
Authors: Tasdemir Rabia , Cihan Omer Faruk 
Published: October 2022

Abstract
Background
As with all healthcare professionals, anatomy is an indispensable course for nursing and midwifery students in order to be successful in other courses and in their professional lives. This survey-based study was conducted with nursing and midwifery students from the Faculty of Health Sciences to find out their perceptions about the “Anatomy” concept through metaphors.
Methods
The metaphor analysis technique was used for the study. This techniques is used as a phenomenological research method as part of a qualitative research approach. The study was conducted between January and February 2021 at a faculty of health sciences of a public university in Turkey. The study universe and sample consisted of the students from the Faculty of Health Sciences of our university. Among a total of 260 nursing and midwifery students, 200 students voluntarily agreed to participate in the study survey. Since 4 students failed to produce valid metaphors, the study was completed with 196 students. The study data were collected using a brief questionnaire on demographic characteristics and by prompting the students to complete the metaphorical statement “Anatomy is like … because…”.
Results
The nursing students produced negative metaphors more commonly than the midwifery students. Despite this, in general, positive metaphors were predominantly produced by the students from both departments. Second year students were found to have more positive views about anatomy than first year students.
Conclusions
Since anatomy is a fundamental discipline for healthcare professionals, the perceptions of nursing and midwifery students about anatomy are very important. While the metaphors of “taking a breath” and “world atlas” about anatomy shows the awareness of the significance of anatomy among the students, metaphors of “ocean”, “abyss” and “desert” are striking examples that indicate how desperate they feel about learning anatomy.
Updated estimate of the breeding population of Adélie penguins (Pygoscelis adeliae) at Penguin Point, Marambio / Seymour Island within the proposed Weddell Sea Marine Protected Area
Authors: Perchivale Pablo J. , Juarés Mariana A. , Santos Mercedes M. , Marti Lucas J. , Silvestro Anahí , Coria Néstor R. Coria 
Published: October 2022

Abstract
The Adélie penguin (Pygoscelis adeliae)is an indicator species of the state of the Antarctic marine environment and this is reflected in the size of its reproductive populations. The mean number of breeding pairs of the Adélie penguin on Penguin Point, Marambio / Seymour Island, east of the Antarctic Peninsula, in the Weddell Sea, increased by 32.4% (λ = 1.01) from 1985/1986 to 2014/2015. Although in intermediate counts, there were fluctuations in the number of couples.
Variations in Adélie penguin populations may be due to natural variables such as the extent of sea ice; quantity and quality of food; winter survival of adults and juveniles; predation; among others, or due to human activities such as commercial fishing. Our study attempts to contribute to the current estimates of the reproductive population of the Adélie penguin in the region and may also contribute to the negotiations for the implementation of the marine protected area proposed in the sector.
Genetic and Environmental Contributions to Subcortical Gray Matter Microstructure and Volume in the Developing Brain
Authors: Watts Richard , Filippi Christopher , Grant Justin 
Published: October 2022

Abstract
Using baseline (ages 9-10) and two-year follow-up (ages 11-12) data from monozygotic and dizygotic twins enrolled in the longitudinal Adolescent Brain and Cognitive DevelopmentSM Study, we investigated the genetic and environmental contributions to microstructure and volume of nine subcortical gray matter regions. Microstructure was assessed using diffusion MRI data analyzed using restriction spectrum imaging (RSI) and diffusion tensor imaging (DTI) models. The highest heritability estimates for microstructure were found using the RSI model in the pallidum (0.862±0.037), putamen (0.845±0.041), and thalamus (0.849±0.040). For volumes the corresponding regions were the brainstem (0.880±0.026), caudate (0.881±0.027) and putamen (0.870±0.030). No significant evidence of contributions of the common environment or changes in the contributions with development were observed. Individual differences in both gray matter microstructure and volumes can be largely explained by additive genetic effects in this sample.
Exploration of ferroptosis-related genes and molecular mechanisms in psoriasis and atherosclerosis
Authors: Li Chunjun , Meng Xiangxiang , Wang Lina , Dai Xia 
Published: October 2022

Abstract

Objective The purpose of this work is to look into the molecular mechanisms underlying the main ferroptosis-related genes in psoriasis (PsD) and atherosclerosis (AS). Methods Download the dataset between PsD patients and normal group (GSE30999) from the GEO database, while obtaining the dataset between AS patients and normal group (GSE100927). Using R software and the limma package in Bioconductor, differentially expressed genes (DE-FRG) were obtained. On the intersecting DE-FRG, enrichment analyses using GO and KEGG were conducted. The functional interactions between DE-FRG were then examined using a protein-protein interaction (PPI) network that was built using the STRING database. In order to analyze the relationship between infiltrating immune cells and Hub genes, the immune cell infiltration in PsD and AS tissues was assessed using CIBERSORT. The DGIdb database was utilized to choose potential Hub gene medication candidates. Finally, a network of lncRNA, miRNA, and mRNA associated to Hub gene was developed. Results 133 DE-FRGs in total, including 67 up-regulated genes and 66 down-regulated genes, were examined. As a total of the screening, 215 DEGs—including 171 up-regulated genes and 44 down-regulated genes—were obtained. DE-FRG was found to be strongly enriched for the FOXO signaling pathway, ferroptosis, fluid shear stress and atherosclerosis, mTOR signaling pathway, relaxin signaling pathway, and AMPK signaling pathway, according to functional enrichment analysis. It was considerably enriched for chemokines, signaling receptor activators, granulocyte chemotactic response, lipopolysaccharide metabolism, and mesovirus defense. Eight genes, including PTEN, STAT3, MAPK3, SIRT1, IL6, HRAS, EGFR, and PPARG, were subsequently included to the Cytoscape Hubba plug-in and the ROC diagnostic curve as Hub genes. Additionally, 222 medicines that target 8 marker genes in total were obtained. On the other hand, the ceRNA network, which was based on Hub genes, revealed intricate regulatory relationships. Additionally, CIBERSORT analysis demonstrated that PTEN, STAT3, MAPK3, SIRT1, IL6, HRAS, EGFR, and PPARG alterations in the immunological milieu of AS and PsD patients may be connected. Conclusion The results could lead to new understandings of the pathogenesis of PsD and AS as well as the discovery of new ferroptosis genes that could be used as potential therapeutic targets in clinical settings or as widely representative reference markers.
High Precision and Real-Time Acquisition System for Interface Stress Measurement in Bridge Bearing
Authors: Cao Xinning , Li Guangming , Li Zhe , Sun Wujie , Yan Fabao , Jiang Ruijuan 
Published: October 2022

Abstract

Since the damage of the bridge structure may cause great disasters, it is necessary to monitor its health status, especially the bridge bearing, the important connecting component of the bridge's upper and lower structures. Nowadays, manual inspection is the main method to get the information of the bridge bearings’ work status. However, occasional damage of bridge bearing may not be detected in time, and sometime the installation position of the bearing makes the manual inspection on bridge bearing difficult and even impossible. Therefore, in order to know the work status of the bridge bearings timely, an intelligent remote monitoring system for the bridge bearing is developed. A 32-channel real-time acquisition system is designed by using an AD7768-1 analog-to-digital converter (ADC) and Xilinx Spartan-6 FPGA for interface stress continuously acquired in the bridge bearing. To assure the good linearity and noise performance of the monitoring system, the data acquisition card is meticulously designed to reduce noise from both hardware and software and realize high-precision acquisition. Through the establishment of the monitoring server, the compressive stress data can be displayed synchronously and the overpressure situation can be alarmed in real-time. The experimental results show that the accuracy of the calibrated sensor is within 1.6%, and the detection error of the acquisition board is less than 200µV. The acquisition system is deemed to have considerable advantages in accuracy and applicability.
Evaluation of the relationship between subcutaneous and visceral abdominal fat diameters and predictors of cardiovascular disease in Iranian adults using ultrasound
Authors: Rad Masoud Pezeshki , Abbasi Bita , Eslami Saeid , Ganjali Raheleh , Honari Sara , Fathabadi Amirhossein , Hasanzade Fateme , Reihani Amirali , Moradi Zahra , Ghalebizadeh Samaneh , Ardabili Hossein Mohaddes , Sani Fatemeh Teimouri 
Published: October 2022

Abstract
Cardiovascular diseases (CVDs) are one the leading causes of death in the world. Obesity is known as one of the essential risk factors for CVDs. According to the available literature, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) are strongly associated with CVDs. This study aims to evaluate the relation between SAT and VAT with other predictors of CVDs, using ultrasound. The present study was conducted in 2018 using the data extracted from a cohort study that was carried out among the staff and faculty members of Mashhad University of Medical Sciences (MUMS). The study group consisted of 797 males and 950 females. The data on anthropometric and biochemical measurements were extracted from the cohort. An ultrasound test was performed to measure the visceral and subcutaneous fat tissue, and IBM SPSS 26 was used to analyze the data. Our findings show that there is a major correlation between VAT and age, weight, waist circumference, and triglycerides. Also, there was a significant association between abdomen circumference, waist circumference, and triglycerides with SAT. The current study highlights the importance of monitoring changes in adipose tissue diameter due to its close connection with CVD risk factors
Atmospheric-ocean coupling drives prevailing and synchronic dispersal patterns of marine species with long pelagic durations
Authors: Ramirez-Romero Eduardo , Amores Angel , Díaz David , Muñoz Anabel , Catalán Ignacio , Molinero Juan Carlos , Ospina-Alvarez Andres 
Published: October 2022

Abstract
Dispersal shapes population connectivity and plays a critical role in marine metacommunities. Prominent species for coastal socioecological systems, such as jellyfish and spiny lobsters, feature long pelagic dispersal phases (LPDPs), which have long been overlooked. Here, we use a cross-scale approach combining field surveys of these species with a high-resolution hydrodynamic model to decipher the underlying mechanisms of LPDP patterns in northwestern Mediterranean shores. We identified basin-scale prevailing dispersal routes and synchronic year-to-year patterns tightly linked to prominent circulation features typical of marginal seas and semienclosed basins, with an outstanding role of a retentive source area replenishing shores and potentially acting as a pelagic nursery area. We show how the atmospheric forcing of the ocean, a marked hydrological driver of the Mediterranean Sea, modulates dispersal routes and sources of LPDP at interannual scales. These findings represent a crucial advance in our understanding of the functioning of metapopulations of species with LPDP in marginal seas and may contribute to the effective management of coastal ecosystem services in the face of climate change.
Pre-scrotal castration procedure in boars
Authors: Câmara Antonio Carlos Lopes , Campebell Rita Cássia , Nogueira Kaique , Junqueira João Vagner Silva , Andrade Tiago Silva , Neto Antonio Raphael Teixeira 
Published: October 2022

Abstract

Background:To report the feasibility of pre-scrotal castration technique in boars and document the great post-surgical evolution, thirty clinically healthy and sexually intact boars were used in a short case series.Results: No wound exsudate or infection was recorded. Mild scrotal edema was reported in 12 (40%) boars, that resolved within 3 days after stall confinement finished. On the long-term follow-up (4-12 months’ post-surgery), all owners stated to be satisfied with the procedure, with minor post-surgical aftercare required.Conclusion: Castration of boars using the pre-scrotal approach is a simple and safe procedure, reducing postoperative complications, and, thereby, providing better welfare, making the postoperative management of the boars, easier for handlers or owners.Methods: Thirty boars were considered fit for pre-scrotal castration technique if the testis and scrotum were macroscopically normal and no perceptible adherences within the scrotum noticed. Dissociative anesthesia protocol and local anesthesia by intratesticular and pre-scrotal infiltrative lidocaine injection was performed. An 8-10 cm skin incision was made cranially to the hemiscrotum, and subcutaneous tissue was bluntly dissected reaching thetunica dartos, fascia, and vaginal tunica. A transfixion ligature was placed on the fibrous-muscle portion of the spermatic cord. Mesorchium was bluntly dissected to separate the spermatic cord from the surrounding fascia, and a double transfixation ligature was placed around the spermatic cord, that was sharply transected. The procedure was repeated on the contralateral testis using the same skin incision.
Transcriptional Coordination between Mitochondrial and Nuclear Genomes for Oxidative Phosphorylation Is Disrupted in Alzheimer’s Brain
Authors: Shang Yuan , Yin Fei , Brinton Roberta Diaz 
Published: October 2022

Abstract
Decline in mitochondrial function and oxidative phosphorylation in Alzheimer’s disease (AD) are well documented which led us to investigate coordination between mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) genomes specific to oxidative phosphorylation (OXPHOS). Using AMP-AD mtDNA and nDNA datasets, regression analyses of OXPHOS transcriptomic, proteomic profiles and AD clinical biomarkers were conducted. Outcomes revealed that mtDNA and nDNA encoded OXPHOS subunits were negatively correlated at mRNA level while positively correlated at protein level in both cognitively normal and AD brains. However, association between mitochondrial and nuclear OXPHOS transcripts was significantly lower in AD brain. Mitochondrial transcripts were positively correlated with Notch signaling while negatively correlated with synapse formation, bioenergetics, translation, and ubiquitin-related pathways in both control and AD brain. mtDNA- transcript levels were negatively correlated with neuronal cell fractions but positively correlated with oligodendrocyte precursor cell fraction. AD biomarkers, β−amyloid, total tau, and neurofibrillary tangle (NFT) burden, were positively correlated with mtDNA transcript levels. Collectively, our findings reveal altered mitochondria-nuclear genome interactions under AD stress, uncoupled mitochondrial / nuclear genome communication in AD, key role of precursor oligodendrocytes in OXPHOS and AD and suggest coordination between mitochondrial and nuclear genomes regulating OXPHOS as a potential therapeutic target in AD.
Research on the Effectiveness and Safety of Bronchial Thermoplasty in Patients with Chronic Obstructive Pulmonary Disease
Authors: Fu Peng , Wang Tao , Long Fa , Liu Shengming , Hu Siyu , Wang Qiongping , Huang Zhihui , Long Liang , Huang Wenting , Hu Fengbo , Gan Jingfan , Dong Hongbo , Yan Guomei 
Published: October 2022

Abstract
Objective
To investigate the clinical efficacy and safety of bronchial thermoplasty (BT) in treating chronic obstructive pulmonary disease (COPD) patients.
Methods
Clinical data of 57 COPD patients were randomized into control (n = 29, conventional inhalation drug) or observation group (n = 28, convention inhalation drug plus BT). Primary outcomes were differences in clinical symptom changes, pulmonary function-related indicators, 6-min walk test (6MWT), COPD assessment test (CAT) score, Modified Medical Research Council (mMRC) and acute exacerbation incidence from baseline to average of 3 and 12 months. Safety was assessed by adverse events.
Results
FVC, FEV1 and FEV1% predicted value in both groups improved to varying degrees post-treatment compared with those pre-treatment (P < 0.05), except for FEV1/FVC. Observation group showed greater increase amplitudes of FEV1 (Ftime × between groups = 21.713, P < 0.001) and FEV1% predicted value (Ftime × between groups = 31.216, P < 0.001) than control groups, with no significant difference in FVC variation trend (Ftime × between groups = 1.705, P = 0.193). mMRC, 6MWT and CAT scores of both groups post-treatment improved to varying degrees (Ps < 0.05), but the improving amplitudes of mMRC (Ftime × between groups=3.947, P = 0.025), 6MWT (Ftime × between groups༝16.988, P < 0.001) and CAT score (Ftime × between groups༝16.741, P < 0.001) in observation group were greater than control groups. According to COPD acute exacerbation risk assessment, the proportion of high-risk COPD patients with acute exacerbation in control and observation groups at 1 year post-treatment (100% vs 65%, 100% vs 28.6%), inpatient proportion (100% vs 62.1%; 100% vs 28.6%), COPD acute exacerbation number [3.0 (2.50, 5.0) vs 1.0 (1.0, 2.50); 3.0(3.0, 4.0) vs 0 (0, 1.0)] and hospitalization number [2.0 (2.0, 3.0) vs 1.0 (0, 2.0); 2.0 (2.0, 3.0) vs 0 (0, 1.0)] were significantly lower than those pre-treatment (P < 0.05). Besides, data of observation group were significantly lower than control group (P < 0.05).
Conclusion
Combined BT treatment better improves lung function and life quality of COPD patients than conventional medical treatment, and reduce the COPD exacerbation risk without serious adverse events.
Autonomous visual detection of drilling-induced defects in CFRPs based on digital image processing
Authors: Zhang Xuyan , Huang Wenjian , Wu Chaoqun , Cao Shiyu 
Published: October 2022

Abstract
Carbon Fiber Reinforced polymers (CFRPs) are critical kind of materials in many industries due to their superior mechanical and physical properties. However, the pivotal mechanical process of CFRPs is considered to be drilling, which easily leads to CFRPs defects including burr and delamination. Although substantial CFRPs defect inspection methods have been suggested, the user-friendly measurement of CFRPs defects and fast measurement speed are still challenging. To this end, a digital-image-processing-based method for identifying and measuring the drilling-induced defects in CFRPs specimens is proposed. By comparing with the manually measured results, it shows that the proposed method can accurately (the maximal relative errors are separately 5.76% and 3.42% for burr factor and delamination factor) and quickly (4 s per micrograph) recognize and measure CFRPs defects. Moreover, the method has no requirement for adjusting any parameters manually and shows strong robustness to the interference from the bright noise. Based on above, the method is anticipated to provide a meaningful reference for recognizing and measuring CFRPs defects in large quantities.