bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnostic significance of integrating m6A modification and immune microenvironment features based on bioinformatic investigation in aortic dissection
Authors: Guo Ruiming , Dai Jia , Xu Hao , Zang Suhua , Zhang Liang , Ma Ning , Zhang Xin , Zhao Lixuan , Luo Hong , Liu Donghai , Zhang Jian 
Published: August 2022

PurposeThe aim of this study was to investigate the role of m6A modification and the immune microenvironment (IME) features in aortic dissection (AD) and establish a clinical diagnostic model for AD based on m6A and IME factors.MethodsGSE52093, GSE98770, GSE147026, GSE153434, and GSE107844 datasets were downloaded from the GEO database. The expression of 21 m6A genes including m6A writers, erasers, readers, and immune cell infiltrates was analyzed in AD and healthy samples by differential analysis and ssGSEA method, respectively. Both correlation analyses between m6A genes and immune cells were conducted by Pearson and Spearman analysis. XGboost was used to dissect the major m6A genes with significant influences on AD. AD samples were classified into two subgroups via consensus cluster and principal component analysis (PCA) analysis, respectively. Among each subgroup, paramount IME features were evaluated. Random forest (RF) was used to figure out key genes from AD and healthy shared differentially expressed genes (DEGs) and two AD subgroups after gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Finally, we constructed an AD diagnostic model combining important m6A regulatory genes and assessed its efficacy.ResultsAmong 21 m6A genes, WTAP, HNRNPC, and FTO were upregulated in AD samples, while IGF2BP1 was downregulated compared with healthy samples. Immune cell infiltrating analysis revealed that YTHDF1 was positively correlated with γδT cell level, while FTO was negatively correlated with activated CD4+ T cell abundance. FTO and IGF2BP1 were identified to be crucial genes that facilitate AD development according to the XGboost algorithm. Notably, patients with AD could be classified into two subgroups among which 21 m6A gene expression profiles and IME features differ from each other via consensus cluster analysis. The RF identified SYNC and MAPK1IP1L as the crucial genes from common 657 shared common genes in 1,141 DEGs between high and low m6A scores of AD groups. Interestingly, the AD diagnostic model coordinating SYNC and MAPK1IP1L with FTO and IGF2BP1 performed well in distinguishing AD samples.ConclusionThis study indicated that FTO and IGF2BP1 were involved in the IME of AD. Integrating FTO and IGF2BP1 and MAPK1IP1L key genes in AD with a high m6A level context would provide clues for forthcoming AD diagnosis and therapy.
Suspended sediment dynamics in macrotidal turbid Hangzhou Bay during Typhoon Chan-hom
Authors: Li Li , Shen Fangzhou , He Zhiguo , Yu Zhuzhu 
Published: August 2022

Typhoons are extreme weather events that cause serious social and economic losses in coastal and estuarine areas worldwide. Understanding the impact of typhoons on sediment dynamics is essential for protecting coastal areas from these marine disasters. Hangzhou Bay is macro-tidal, turbid, and frequently affected by strong typhoons. In this study, we established and validated a three-dimensional model coupling waves, current, and sediment to investigate the sediment dynamics in Hangzhou Bay during Typhoon Chan-hom. The results showed that high suspended sediment concentration (SSC) areas during the typhoon were mainly located at the bay head and near the southern shore near the Andong tidal flat. The maximum bottom SSC was at least twice that near the surface. The peak bottom SSC values at the peak flood (6 g/L) were larger than those at the peak ebb (5 g/L) owing to the stronger current velocity at peak flood. The SSC near the northern shore was larger at the peak flood than at other times, and the SSC was high at the southern shore at peak ebb at the cross-section near the Andong tidal flat. The typhoon impacted SSC by changing the bottom stress. SSC was most influenced by wave action, followed by wind stress action, and was least influenced by air pressure action, which contributed 71.3%, 69.9%, and 1.8% to the bottom stress, respectively. Our findings are scientifically important for research on geomorphological evolution and are practically meaningful for coastal management.
Timing and implications of aeolian sand accumulation in a alpine basin of Qilian Shan, NE Tibetan Plateau
Authors: Yang Na , Zhang Jingran , Cai Yun , Feng Yuye , Yang Linhai , Cheng Hongyi , Long Hao 
Published: August 2022

The reconstruction of regional moisture and climate changes during the Holocene has been intensively carried out over the NE Tibetan Plateau, based on different geological archives. However, owing to either the lack of robust independent chronology or ambiguous interpreting of climate proxies as well as complex geographic settings within the plateau, the nature of Holocene environmental changes and their influence factors remain controversial, particularly on whether the optimal climate condition (effective moisture peak) has prevailed during the early- or mid-Holocene. In this study, we reported a new well-dated sand dune accumulation record from the Shawotou sand field in the Babao River drainage area in the southeast Qilian Mountains, to unravel the late glacial and Holocene moisture variation history. The robust chronologies of aeolian sands and palaeosols from two sections were established based on densely collected 49 samples using post-infrared (IR) IR-stimulated luminescence dating of coarse-grained K-feldspar. Based on stratigraphic investigation of the sand dune/palaeosol sections, the results show that the climatic condition was very dry during the late glacial and early Holocene (14–8 ka), characterized by sand dune formation, and then the moisture peaked in the middle Holocene (8–4 ka) with the strongest pedogenesis, followed by a relatively dry condition in the late Holocene (since 4 ka). The regional comparison suggested that the Holocene moisture variation pattern seems synchronous over the NE Tibetan Plateau, that is, the dry early Holocene and late Holocene but with peaked moisture in the middle Holocene, which is likely attributed to the precipitation changes of the East Asian summer monsoon.
Fractal analysis of pore structures in transitional shale gas reservoirs in the Linxing area, Ordos Basin
Authors: Shi Shuai , He Jinxian , Zhang Xiaoli , Wu Hongchen , Yu Ziqi , Wang Jian , Yang Tiantian , Wang Wei 
Published: August 2022

Studying complex pore structures and fractal characteristics of gas shale provides significant guidance for clarifying the mechanism of shale gas accumulation and realizing its efficient development. In this paper, 12 samples of Taiyuan Formation shale are used as the research object, and the fractal theory is combined with mercury intrusion porosimetry and N2 adsorption technology to innovatively solve the problem of splicing point selection, which can reveal the full-scale pore size distribution of shale. The results demonstrate that the most common types of pores in the chosen samples are pores between or within clay minerals, micropores and mesopores inside organic matter, and microfractures, based on scanning electron microscopy imagery analyses. The pores of shale samples have fractal geometries. The fractal dimension DM1 values in the mercury intrusion porosimetry experiments range from 2.3060 to 2.6528. Two fractal dimensions, DN1 and DN2, may be obtained using the Frenkel-Halsey-Hill fractal method. DN1 values vary from 2.4780 to 2.6387, whereas DN2 values range from 2.5239 to 2.7388. Most macropores in shale samples have a size range of about 0.2 mm, with a wide pore size distribution, and the largest peak of the micro-mesopore volume is generally about 50 nm. The fractal dimension correlates positively with the corresponding pore volume, although the correlation between volume and composition is weak. The relatively strong correlation between fractals and the basic compositions of shale proves the fractal theory’s relevance in defining pore inhomogeneity. This study would contribute to the development of a fractal perspective-based method for pore splicing while also expanding our understanding of pore morphology and structure in transitional shale.
Body mass index and glioma risk: A prospective multicenter study
Authors: Shao Chuan , Tang Hui , Wang Xiaoya , He Jiaquan , Wang Pan , Wu Nan 
Published: August 2022

BackgroundThe association between glioma risk and body mass index (BMI) remains obscure.MethodsThis study aimed to assess the association between glioma risk and BMI in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Cox proportional hazards regression was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsThe onset of a total of 269 gliomas was observed during a median follow-up period of 12.04 years. Compared with the normal weight, overweight (HR: 1.05; 95% CI: 0.80, 1.39) and obesity (HR: 0.91; 95% CI: 0.56, 1.39) were not significantly associated with glioma risk. Further analysis showed a nonlinear relationship between glioma risk and BMI in men but not women. The multivariable-adjusted HRs per unit increase in BMI were 0.94 (95% CI: 0.89, 1.00; P = 0.037) in men with BMI &gt;25 kg/m2 and 1.16 (95% CI: 0.98, 1.38; P = 0.075) in men with BMI &lt;25 kg/m2.ConclusionThe present data provide evidence that there may be a nonlinear association between BMI and glioma risk in men. The risk of glioma decreased with increasing BMI among men with BMI &gt;25 kg/m2. Future studies are needed to validate our observation.
Mediating effect analysis of visceral adiposity index on free triiodothyronine to free thyroxine ratio and non-alcoholic fatty liver disease in euthyroid population
Authors: Liu Huan-Xin , Ren Yan-Yan , Meng Cui-Qiao , Li Zhong , Nie Qian , Yu Chun-Hong , Ma Hui-Juan 
Published: August 2022

BackgroundThe association between free triiodothyronine/free thyroxine (FT3/FT4) and non-alcoholic fatty liver disease (NAFLD) in euthyroid subjects is unclear. In addition, few studies have explored whether VAI mediates the association between FT3/FT4 ratio and NAFLD in the euthyroid population. We aimed to analyze the mediating effect of VAI on the FT3/FT4 ratio and NAFLD risk in the euthyroid population.MethodsThis cross-sectional study included 7 946 annual health examinees from the Health Examination Center, Hebei General Hospital, from January to December 2020. The basic information and biochemical parameters, as well as calculated FT3/FT4 ratio and VAI were collected. NAFLD was diagnosed according to abdominal ultrasonography. The fibrosis score for NAFLD positive subjects (NFS) was calculated to reflect the extent of liver fibrosis. The risk of NAFLD was analyzed by quartiles of FT3/FT4 ratio (Q1-Q4 quartiles) and VAI (V1-V4 quartiles), respectively. Pearson correlation analysis was performed to investigate the correlation between FT3/FT4 ratio and VAI. Multivariate logistic regression analysis was applied to analyze the effect of FT3/FT4 ratio and VAI on NAFLD and NFS status. Bootstrap was conducted to explore whether VAI mediated the association between FT3/FT4 ratio and NAFLD.ResultsOf the 7 946 participants, 2 810 (35.36%) had NAFLD and 5 136 (64.64%) did not. Pearson correlation analysis indicated that FT3/FT4 ratio was positively associated with VAI (P&lt;0.05). Multivariate logistic regression analysis indicated that compared to the Q1 group, the risk of NAFLD significantly increased in Q3 group [OR=1.255, 95%CI (1.011, 1.559)] and Q4 group [OR=1.553, 95%CI (1.252, 1.926)](P&lt;0.05). Compared to the V1 group, the risk of NAFLD notably increased in V2 group [OR=1.584, 95%CI (1.205, 2.083)], V3 group [OR=2.386, 95%CI (1.778, 3.202)] and V4 group [OR=4.104, 95%CI (2.835, 5.939)] (P&lt;0.01). There was no relevance between FT3/FT4 ratio, VAI and NFS status. Mediating effect analysis showed that FT3/FT4 ratio significantly directly influenced NAFLD prevalence [β=3.7029, 95%CI (2.9583, 4.4474)], and VAI partly mediated the indirect effect of the FT3/FT4 ratio on NAFLD prevalence [β=2.7649, 95%CI (2.2347, 3.3466)], and the mediating effect accounted for 42.75% of the total effects.ConclusionBoth FT3/FT4 ratio and VAI were predictors of NAFLD, and VAI partly mediated the indirect effect of the FT3/FT4 ratio on NAFLD prevalence in the euthyroid population.
Assessment of prevalence, knowledge of polycystic ovary syndrome and health-related practices among women in klang valley: A cross-sectional survey
Authors: Goh Jia Ean , Farrukh Muhammad Junaid , Keshavarzi Fazlollah , Yap Chuan Sheng , Saleem Zikria , Salman Muhammad , Ramatillah Diana Laila , Goh Khang Wen , Ming Long Chiau 
Published: August 2022

BackgroundPolycystic ovary syndrome (PCOS) is a common metabolic and reproductive disorder affecting women of childbearing age. Its symptoms associated with androgen excess and menstrual abnormalities have great impact on the quality of life in women with PCOS. Data on the knowledge of PCOS and health-related practices among Malaysian women is scarce. This study aimed to determine the prevalence, knowledge and health-related practices of PCOS among women in Klang Valley, Malaysia.MethodA descriptive cross-sectional study was conducted among women in Klang Valley, Malaysia using a self-administered questionnaire. Participants were conveniently recruited through online platforms. Questionnaire consisted of four sections. The knowledge scores ranged from 0-20 where &lt; 10 was classified as poor knowledge. Health-related practices scores ranged from 10-50, with score &lt;30 was classified as poor practice. Descriptive statistics was used to report demographic characteristics. Inferential statistics was used to report the differentiation, association, and correlations of the variables.ResultsA total of 410 respondents participated in this survey. The finding revealed that 43 (10.49%) respondents had medical diagnosis of PCOS, 11 (2.68%) were diagnosed with PCOS based on signs and symptoms, and 135 (32.93%) were suspected with PCOS. Nearly half of the respondents had poor knowledge (47.30%) and poor practice (47.60%) of PCOS. Also, 46 (11.22%) respondents reported abnormal scalp hair loss and 30 (7.32%) respondents had diabetes. Educational levels and PCOS history were significantly associated with PCOS knowledge. Respondents with healthcare related educational background demonstrated good knowledge (p&lt;0.01). Majority of respondents (n= 328, 80%) were unable to control their diets on weekends. Married participants and aged between 40 to 45 women showed better practice of PCOS.ConclusionNearly half of the respondents had poor knowledge and health-related practices towards PCOS. Women with suspected or diagnosed PCOS should seek immediate medical help as early diagnosis and treatment for PCOS are beneficial in improving their quality of life.
Fluorinated co-solvent electrolytes for high-voltage Ni-rich LiNi0.8Co0.1Mn0.1O2 (NCM811) positive electrodes
Authors: Chen Mingming , Liu Zezhao , Zhao Xinzhe , Li Kuihao , Wang Kehuang , Liu Zhishan , Xia Lan , Yuan Jinliang , Zhao Ruirui 
Published: August 2022

Nickel-rich LiNi0.8Co0.1Mn0.1O2 (NCM811) is one of the most promising positive electrodes for utilization in the next-generation of lithium-ion batteries. Charging the NCM cells above 4.3 V is proposed to be beneficial for its reversible capacity. However, the high reactivity of the NCM811 usually results in parasitic electrolyte degradation, which is accelerated with the increase of the Ni content in the NCM positive electrodes, leading to the thickening of the positive electrode-electrolyte interphase during cycling. Herein, to counter this issue, we select partially fluorinated solvents, such as methyl 3,3,3-trifluoropropanoate (MTFP) and 1,1,1,2,2,3,3,4,4-nonafluoro-4-methoxybutane (NFMB), as a co-solvent for fluoroethylene carbonate (FEC)-based electrolytes, and detailed investigate theirs physical, chemical, and electrochemical properties for applications in NCM811 materials. Compared to the carbonate-based electrolyte without a fluorinated solvent, the electrolytes with a fluorinated co-solvent display an obviously enhanced cycling performance of the Li/NCM811 cells charged to above 4.5 V. This work suggests that fluorinated co-solvent electrolytes provide an alternative way to the high-concentration electrolyte for the design of new electrolyte systems for high energy density lithium-ion batteries.
Comprehensive characterization of formation rock for tight oil exploitation
Authors: Kang Hao , Zhou Xinyu , Gao Jian , Zhang Chunxiang 
Published: August 2022

Although it is generally very difficult to supplement flow energy into the tight oil reservoir, there is still good prospect for enhanced oil and gas recovery in this area due to its large proportion of hydrocarbon reserves. However, due to the sensitivity of tight oil reservoir to formation pressure, the porosity and permeability of the reservoir will change greatly with the change of formation pressure in the process oil development, which has a complex impact on dynamic analysis, productivity evaluation and later adjustment of potential stimulation measures. This study mainly focus on the characterization of tight formation rock in the Northwest part of China. In order to get a visual impression of the reservoir core, some routine tests were firstly carried out. After that, porosity and permeability are tested under overburden pressure conditions. Studies show that overburden porosity and permeability will decrease but total decrease percentage will increase with the increase of net effective overburden pressure. The decrease percentage of permeability is much higher compared with that of porosity decrease percentage under overburden pressures. When the net effective overburden pressure is larger than 10 MPa, the decrease of overburden porosity will become relatively small. At the same time, when the net effective overburden pressure is larger than 15 MPa, the decrease of overburden permeability will become relatively small. Taking the pressure-increasing process and the pressure-decreasing process as a whole: the permeability cannot recover to the initial level when overburden pressure is the same as previous round because certain permeability is permanently damaged in the process. At the same time, when the net effective overburden pressure increased to a higher level, the permeability damaged will become relatively smaller. These experiments compose of a comprehensive characterization of formation rock and are of great significance to accurately understand the reservoir damage in the process of tight oil development and reasonably evaluate the productivity of oil producers.
Effects of the annular eclipse on the surface O3 in yunnan province, China
Authors: Tian Yufeng , Li Jingyuan , Yang Chaolei , Cui Jingqi , Shen Fuzhen , Lu Jianyong , Xiong Shiping , Wei Guanchun , Li Zheng , Zhang Hua , Yang Guanglin , Wu Yewen , Wei Zong , Jiang Shuwen , Yao Jingrui , Wang Jingye , Zhu Zhixin 
Published: August 2022

The impact of the annual solar eclipse, starting on 21st June 2020, attributable to surface ozone concentration (O3) has been investigated in this study. To estimate the influence of the solar eclipse on O3 better, the variations of one reaction precursor of ozone production [nitrogen dioxide (NO2)], coupled with the meteorological factors (including Total Solar Irradiance (TSI), Temperature (T), and Relative Humidity (RH)), were analyzed in Yunnan Province, China. The results show observed O3 decreases from the beginning of the eclipse, reaching its minimum value when the eclipse left Yunnan province. During the period of the solar eclipse, the O3 decrease lasted for 20 h with a reduction of more than 40%. The reduction of TSI lasted for 5 h with a maximum at -90%. Simultaneously, the temperature decreased but the relative humidity increased during the reduction in solar radiation. O3 exhibits a significantly positive correlation with temperature and a negative correlation with relative humidity. However, NO2 did not show a clear response with changes lasting for 4 h. O3 and NO2 show a negative correlation. The influence of CO on O3 is minor except for Kunming. Thus, O3 in seriously polluted cities is more sensitive to NO2 and CO during the eclipse, such as in Kunming.
Phenotype-Genotype analysis of caucasian patients with high risk of osteoarthritis
Authors: Wang Yanfei , Chyr Jacqueline , Kim Pora , Zhao Weiling , Zhou Xiaobo 
Published: August 2022

Background: Osteoarthritis (OA) is a common cause of disability and pain around the world. Epidemiologic studies of family history have revealed evidence of genetic influence on OA. Although many efforts have been devoted to exploring genetic biomarkers, the mechanism behind this complex disease remains unclear. The identified genetic risk variants only explain a small proportion of the disease phenotype. Traditional genome-wide association study (GWAS) focuses on radiographic evidence of OA and excludes sex chromosome information in the analysis. However, gender differences in OA are multifactorial, with a higher frequency in women, indicating that the chromosome X plays an essential role in OA pathology. Furthermore, the prevalence of comorbidities among patients with OA is high, indicating multiple diseases share a similar genetic susceptibility to OA.Methods: In this study, we performed GWAS of OA and OA-associated key comorbidities on 3366 OA patient data obtained from the Osteoarthritis Initiative (OAI). We performed Mendelian randomization to identify the possible causal relationship between OA and OA-related clinical features.Results: One significant OA-associated locus rs2305570 was identified through sex-specific genome-wide association. By calculating the LD score, we found OA is positively correlated with heart disease and stroke. A strong genetic correlation was observed between knee OA and inflammatory disease, including eczema, multiple sclerosis, and Crohn’s disease. Our study also found that knee alignment is one of the major risk factors in OA development, and we surprisingly found knee pain is not a causative factor of OA, although it was the most common symptom of OA.Conclusion: We investigated several significant positive/negative genetic correlations between OA and common chronic diseases, suggesting substantial genetic overlaps between OA and these traits. The sex-specific association analysis supports the critical role of chromosome X in OA development in females.