bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergence of counting in the brains of 3- to 5-year-old children
Authors: Kersey Alyssa J. , Aulet Lauren S. , Cantlon Jessica F. 
Published: December 2022

AbstractLearning to map number words onto their ordinal and quantitative meanings is a key step in the acquisition of formal mathematics. Previous neuroimaging work suggests that the intraparietal sulcus (IPS), the inferior frontal gyrus (IFG), and the fronto-temporal language network may be involved in representing number words. However, the contribution of early-developing numerosity representations to the acquisition of counting has not been tested in children. If regions that support numerosity processing are important for the acquisition of counting, then there should be functional overlap between numerosity representations and number word representations in the brain, before children have mastered counting. Using functional magnetic resonance imaging (fMRI), we identified numerosity processing regions in 3- to 5-year-old children during a numerosity comparison task. To identify neural representations of number words, we measured changes in neural amplitudes while those same children listened to number words and color words and while they listened to counting and alphabet sequences. Across multiple whole-brain analyses, we found that the bilateral IPS consistently supported representations of numerosities, number words, and counting sequences. Functional overlap between numerosities and unknown counting sequences was also evident in the left IFG, and in some cases number word representations emerged in the left hemisphere fronto-temporal language network. These results provide new evidence from children that primitive numerosity processing regions of the brain interface with the language network to ground the acquisition of verbal counting.HighlightsfMRI data revealed the neural basis of counting acquisition in 3- to 5-year-olds.Overlap between neural responses to count words and numerosity emerged in the IPS.Sensitivity to number words emerged in the IPS across two different tasks.Number word stimuli also engaged regions of the language network in children.The IPS and language network may ground number words during counting acquisition.
Preclinical evaluation of PHH-1V vaccine candidate against SARS-CoV-2 in non-human primates
Authors: Prenafeta Antoni , Bech-Sàbat Gregori , Moros Alexandra , Barreiro Antonio , Fernández Alex , Cañete Manuel , Roca Mercè , González-González Luis , Garriga Carme , Confais Joachim , Toussenot Marion , Contamin Hugues , Pizzorno Andrés , Rosa-Calatrava Manuel , Pradenas Edwards , Marfil Silvia , Blanco Julià , Rica Paula Cebollada , Sisteré-Oró Marta , Meyerhans Andreas , Lorca Cristina , Segalés Joaquim , Prat Teresa , March Ricard , Ferrer Laura 
Published: December 2022

SUMMARYSARS-CoV-2 emerged in December 2019 and quickly spread worldwide, continuously striking with an unpredictable evolution. Despite the success in vaccine production and mass vaccination programmes, the situation is not still completely controlled, and therefore accessible second-generation vaccines are required to mitigate the pandemic. We previously developed an adjuvanted vaccine candidate coded PHH-1V, based on a heterodimer fusion protein comprising the RBD domain of two SARS-CoV-2 variants. Here, we report data on the efficacy, safety, and immunogenicity of PHH-1V in cynomolgus macaques. PHH-1V prime-boost vaccination induces high levels of RBD-specific IgG binding and neutralising antibodies against several SARS-CoV-2 variants, as well as a balanced Th1/Th2 cellular immune response. Remarkably, PHH-1V vaccination prevents SARS-CoV-2 replication in the lower respiratory tract and significantly reduces viral load in the upper respiratory tract after an experimental infection. These results highlight the potential use of the PHH-1V vaccine in humans, currently undergoing Phase III clinical trials.
A High-Throughput Screen Reveals the Structure-Activity Relationship of the Antimicrobial Lasso Peptide Ubonodin
Authors: Thokkadam Alina , Do Truc , Ran Xinchun , Brynildsen Mark P. , Yang Zhongyue J. , Link A. James 
Published: December 2022

AbstractTheBurkholderia cepaciacomplex (Bcc) is a group of bacteria including several opportunistic human pathogens. Immunocompromised individuals and cystic fibrosis patients are especially vulnerable to serious infections by these bacteria, motivating the search for compounds with antimicrobial activity against the Bcc. The natural product ubonodin is a lasso peptide with promising activity against several Bcc species, working by inhibiting RNA polymerase in susceptible bacteria. In this study, we developed a high-throughput screen using next-generation sequencing to examine the fitness of a library of over 90,000 ubonodin variants, generating the most comprehensive dataset on lasso peptide activity so far. This screen revealed information regarding the structure-activity relationship of ubonodin over a large sequence space, indicating certain residues that can tolerate amino acid substitutions and still retain activity. Remarkably, the screen identified one variant with not only improved activity compared to wild-type ubonodin but also a sub-micromolar minimum inhibitory concentration (MIC) against a clinical isolate of the Bcc memberBurkholderia cenocepacia. Ubonodin and several of the variants identified in this study had a lower MIC against certain Bcc strains than many clinically approved antibiotics. Finally, the large library size enabled us to develop DeepLasso, a deep learning model that can predict the RNAP inhibitory activity of an ubonodin variant.
2-Thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses
Authors: Uemura Kentaro , Nobori Haruaki , Sato Akihiko , Toba Shinsuke , Kusakabe Shinji , Sasaki Michihito , Tabata Koshiro , Matsuno Keita , Maeda Naoyoshi , Ito Shiori , Tanaka Mayu , Anraku Yuki , Kita Shunsuke , Ishii Mayumi , Kanamitsu Kayoko , Orba Yasuko , Matsuura Yoshiharu , Hall William W. , Sawa Hirofumi , Kida Hiroshi , Matsuda Akira , Maenaka Katsumi 
Published: December 2022

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes significant morbidity and mortality worldwide, seriously impacting not only human health but also the global economy. Furthermore, over 1 million cases of newly emerging or re-emerging viral infections, specifically dengue virus (DENV), are known to occur annually. Because no virus-specific and fully effective treatments against these and many other viruses have been approved, they continue to be responsible for large-scale epidemics and global pandemics. Thus, there is an urgent need for novel, effective therapeutic agents. Here, we identified 2-thiouridine (s2U) as a broad-spectrum antiviral nucleoside analogue that exhibited antiviral activity against SARS-CoV-2 and its variants of concern, including the Delta and Omicron variants, as well as a number of other positive-sense single-stranded RNA (ssRNA+) viruses, including DENV. s2U inhibits RNA synthesis catalyzed by viral RNA-dependent RNA polymerase, thereby reducing viral RNA replication, which improved the survival rate of mice infected with SARS-CoV-2 or DENV in our animal models. Our findings demonstrate that s2U is a potential broad-spectrum antiviral agent not only against SARS-CoV-2 and DENV but other ssRNA+ viruses.
A configurational approach to understanding trust in rural tourism accommodation during the COVID-19 pandemic crisis
Authors: Pinho José Carlos , Nogueira Sónia , Macedo Isabel 
Published: December 2022

Purpose
Consumer trust plays a key role in the development and maintenance of long-term relationships in the tourism sector. This study aims to examine the antecedents of trust in the local accommodation sector, which faced a disruptive period due to the COVID-19 pandemic. It also addresses the trust–loyalty relationship.

Design/methodology/approach
A survey was administered to a sample of rural accommodation tourists during the COVID-19 pandemic. A mixed-method approach was used to analyse data; in particular, a PLS-SEM approach was used, followed by a fuzzy-set qualitative comparative analysis (fsQCA).

Findings
This study confirms and reinforces the importance of a positive influence of affective evaluation, reputation, perceived security and the destination image on perceived trust. It also demonstrates the impact of trust on loyalty. Using fsQCA, it was found that perceived security is a necessary condition to achieve perceived trust. However, there are multiple paths to achieving high trust.

Research limitations/implications
This article provides a practical and theoretical contribution to this phenomenon during the pandemic crisis. This study concludes that implementing specific measures to increase perceived security (e.g. clean and safe seal) was critical to increase trust and loyalty.

Practical implications
Although the decrease in visits has had a significant impact on economic activities, the nature of the context, in particular the rural context, proved that the combination of agricultural activities with tourism services offering also revealed to be a promising complementary strategy to help owners and minimize the lack of visitors.

Originality/value
This study is one of the earliest to understand trust and its antecedents and trust loyalty during the COVID-19 pandemic.
Mitigating the impact of Covid-19: Social Safety Net from Islamic perspective
Authors: Widiastuti Tika , Rusgianto Sulistya , Mawardi Imron , Fanani Sunan , Ali Mohammad Mahbubi , Al Mustofa Muhammad Ubaidillah , Fadlul Hady Aufar 
Published: December 2022

Purpose
This study aims to propose priority solutions for mitigating the impact of the Covid-19 pandemic through the Social Safety Net (SSN) based on the Islamic objectives.

Design/methodology/approach
The analytic network process method is used in this study. Focus group discussions and in-depth interviews with relevant stakeholders were used to collect data and supplemented by a literature review to explore comprehensive information.

Findings
The findings indicate different opinions among experts, including regulators, practitioners, associations and academics regarding the most important priority solutions to the impact of Covid-19. However, experts agree that the highest priority solution is the SSN program in the lineage sector, specifically the distribution of the Family Hope Program. A program in the field of protecting the mind is the second priority solution. The program in the field of soul and wealth is the third priority solution.

Originality/value
This study contributes to the development of government policy to deal with the socioeconomic impact of Covid-19 based on the Islamic objectives by mapping the SSN through the five elements of protection, namely, faith, soul, mind, lineage and wealth protection based on priority solution.
Lecturers' perceptions of authentic assessment in times of COVID-19 pandemic: a case of Indonesian universities
Authors: Ibrahim Misykat Malik , Malik Marhany , Avianti Ratu Amilia 
Published: December 2022

PurposeThe present study aims to provide a better understanding of authentic assessment in the COVID-19 pandemic era by exploring how Indonesian lecturers perceive authentic assessment in terms of input, process and output. It also examines the issue through the theoretical lens of authentic assessment following the tenet of a five-dimensional framework (5DF) including assessment task, physical context, social context, assessment result and standard authentic criteria.Design/methodology/approachThe study employed an exploratory sequential mixed-methods design to garner data through qualitative interviews and authentic assessment questionnaires in which 48 lecturers from four universities were involved.FindingsThe study gleaned two important findings. The qualitative data showed that the university teachers enacted the cognitive assessment fruitfully. The study shows that lecturer participants experienced difficulties in integrating cognitive, psychomotor and affective domains into authentic assessment tasks during the teaching and learning process. Additionally, the results of quantitative data support the qualitative data that lecturer participants faced challenges (asking students to demonstrate or perform the tasks) in implementing both social and physical contexts in authentic assessment tasks of online learning during COVID-19 pandemic.Research limitations/implicationsThe present study addresses practical and conceptual implications. Practically, it suggests the need to facilitate the development of lecturers' technological skills to design online authentic assessment in higher education that responds to fully online assessment, such as the prevalence of COVID-19 pandemic. Meanwhile, the study suggests that lecturers need to build their understanding of 5DF theoretical lens which include assessment tasks, physical contexts, social contexts, assessment result and standard authentic criteria to enhance their literacy in enacting authentic assessment.Originality/valueAlthough many studies have investigated the implementation of authentic assessment in higher education, only a few have examined how lecturers perceived online authentic assessment during the COVID-19 pandemic. The present study contributes to developing conceptual and empirical evidence regarding lecturers' perception of the implementation of authentic assessment based on 5DF theoretical lens in higher education settings during the pandemic of COVID-19.
Humanitarian aid distribution logistics with accessibility constraints: a systematic literature review
Authors: Rojas Trejos Carlos Alberto , Meisel Jose D. , Adarme Jaimes Wilson 
Published: December 2022

PurposeThe purpose of this paper is to review the relevant literature in order to identify trends and suggest some possible directions for future research in the framework of humanitarian aid distribution logistics with accessibility constraints.Design/methodology/approachThe authors developed a systematic literature review to study the state of the art on distribution logistics considering accessibility constraints. The electronic databases used were Web of science, Scopus, Science Direct, Jstor, Emerald, EBSCO, Scielo and Redalyc. As a result, 49 articles were reviewed in detail.FindingsThis study identified some gaps, as well as some research opportunities. The main conclusions are the need for further studies on the interrelationships and hierarchies of multiple actors, explore intermodality, transshipment options and redistribution relief goods to avoid severe shortages in some nodes and excess inventory in others, studies of the vulnerability of transport networks, correlational analysis of road failures and other future lines.Research limitations/implicationsThe bibliography is limited to peer-reviewed academic journals due to their academic relevance, accessibility and ease of searching. Most of the studies included in the review were conducted in high-income countries, which may limit the generalizability of the results to low-income countries. However, the authors focused on databases covering important journals on humanitarian logistics.Originality/valueThis paper contextualises and synthesises research into humanitarian aid distribution logistics with accessibility constrains, highlights key themes and suggests areas for further research.
Internet of things, big data analytics and operational performance: the mediating effect of supply chain visibility
Authors: Al-Khatib Ayman Wael 
Published: December 2022

PurposeThis paper aims to investigate hypothesized relationships between the Internet of things (IoT) and big data analytics (BDA) with supply chain visibility (SCV) and operational performance (OP) in the pharmaceutical manufacturing sector in Jordan. The paper also aims to test the conceptual model related to the indirect effects of SCV.Design/methodology/approachTo achieve the objectives of this paper, a conceptual model was developed through a review of the current literature. Data analysis was performed by covariance-based structural equation modelling using Amos 25 software, and the convergent validity, discriminant validity, reliability and confirmatory factor analysis were verified. Then the hypotheses were tested.FindingsThe results of the study indicate that there is a positive and statistically significant relationship between the IoT and BDA on SCV and OP. The relationship was positive and statistically significant between SCV and OP. In addition, support for the mediation hypothesis that SCV mediates the relationship among IoT, BDA and OP was confirmed.Originality/valueThis paper provides new theoretical and managerial contributions that have not been covered in previous studies, and it is considered the first study that uses this conceptual model with this mechanism in terms of the theoretical lens and empirical application. This paper contributes to understanding the dynamic mechanisms of the IoT and BDA in enhancing OP, which contributes to creating a supply chain capable of facing various environmental fluctuations and pressures. This study presents new implications that can be used in the supply chain literature.
White, Brown, mad, fat, male and female academics: a duoethnography challenging our experiences of deficit identities
Authors: Fox Joanna , Sangha Jas 
Published: December 2022

PurposeThe authors are two social work academics working in a UK Higher Education Institute. Social work is underpinned by principles of anti-oppressive practice which leads to challenge discrimination and stigmatisation. The authors explored experiences of deficit imposed by others' perceptions of the physical and ethnic appearance and mental health status. The authors consider how these features influence how the authors locate themselves within the wider contexts of academic spaces in higher education institutions (HEI).Design/methodology/approachUsing duoethnography, a collaborative research methodology, the authors recorded reflections on their experiences for five months and met weekly to discuss their material. This process enabled them to engage in dialogic narrative through collaborative writing using both structured and unstructured reflections. The authors analysed the reflections using thematic data analysis.FindingsFour themes were generated that led to understanding how the authors could challenge oppression. The oppression became visible as the authors reflected on the common experiences of deficit. The understanding of other's oppression as well as the authors’ own became clearer as the unconscious experiences became conscious. The authors began to locate the experiences of being both privileged and oppressed in the wider social context of the HE. Finally, the authors recognised how the “deficit” identities could transform into strengths.Originality/valueThis personal journey of two academics reflecting on how they are paradoxically both privileged and yet oppressed challenges other professionals to honestly explore how they themselves can occupy both roles and become allies in confronting discrimination in all its forms.
How a sense of collective efficacy influences teacher learning during change: the role of academic optimism and shared vision
Authors: Vanlommel Kristin , van den Boom-Muilenburg Selia Neeske , Thesingh Jan , Kikken Èvi 
Published: December 2022

PurposeThe purpose of this study is twofold. First, this study reflects on the development of professional capital through understanding collective cultural factors, namely, academic optimism and shared vision. Second, it aims at exploring teacher learning. Teacher learning resulting in changes to teacher knowledge, attitudes and practices is crucial for the necessary changes education is continually confronted with. This learning is too often studied as a result of individual traits or structural factors, such as motivation or time. The authors investigated how teacher learning is influenced by academic optimism and shared vision.Design/methodology/approachThe authors administered an online web-based survey to 278 teachers in higher education, using the educational change to online learning due to the covid pandemic as a unique chance to study the role of collective cultural factors in teacher learning.FindingsResults showed how teachers characterized their learning, academic optimism and shared vision during the educational change to online learning resulting from the covid pandemic. The authors found that teacher learning was greatly influenced by teachers' collective sense of efficacy, an aspect of their academic optimism. Teachers' strong belief in each other, that they as fellow professionals could handle the challenging changes that the covid pandemic required, strongly enhanced teacher learning during the covid pandemic. Teachers' feeling of a professional community helped teacher to make sense of, and push through, the undeniable chaos that was the covid pandemic.Originality/valueCollective cultural factors are rarely studied in conjunction with educational change. Insights into how a collective culture of professionalism enhances or hinders teacher learning are important for theory, policy and practice as it helps understand how teacher teams can be supported to build their professional capital by learning from educational change.
I see myself in my leader: transformational leadership and its impact on employees' technology-mediated knowledge sharing in professional service firms
Authors: Nguyen Mai 
Published: December 2022

PurposeKnowledge is the main product of professional service firms; therefore, knowledge is the key to success. Due to the nature of this organizational type, management in professional service firms has faced many challenges in encouraging employees to share knowledge. The diffusion of technologies has facilitated technology-mediated knowledge sharing (TMKS), which helps the transfer of knowledge become easier without time and space limits. This study aims to unfold the impact of transformational leadership as an antecedent of TMKS under the interplay with perceived ease of use and perceived usefulness in using technology.Design/methodology/approachAn online survey was distributed to employees in professional service firms through the snowball sampling method. Three hundred forty employees, who had experience with technology-mediated knowledge sharing, participated in the survey.FindingsThe findings showed that transformational leadership had a significant impact on TMKS, which was moderated by perceived usefulness and gender. TMKS influenced organizational innovation, and the mediating effect of TMKS was identified.Originality/valueThis study provides solutions for management in professional service firms to motivate their employees to share knowledge via technology, which drives organizational innovation. More caution about gender differences and the low levels of perceived usefulness from employees need to be considered when adopting transformational leadership.