bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-silico characterization of phytochemicals identified from Vitex negundo (L) extract as potential therapy for Wnt-signaling proteins
Authors: Gouthami Kuruvalli , Veeraraghavan Vadamalai , Nagaraja Prashantha 
Published: January 2022

Abstract
Background
Colorectal cancer is the third most diagnosed disease in the world population and current chemotherapy has been used for targeting the cell proliferation and metastasizing ability of tumor cells. Potent chemotherapeutic drugs for colorectal cancer are capecitabine, fluorouracil, irinotecan, etc. which have toxic effects in normal tissues and adverse effects in multiple organs leading to major obstacles in clinical use. The aim of the study is the use of plant-derived compounds that improve the effectiveness of chemotherapeutics with lower and alleviate toxic side effects and reduce the risk of tumor progression.

Results
The current study is performed using Vitex negundo leaf which has been demonstrated to have positive effects against colorectal cancer. The use of computational approaches will help improve the identification and screening of lead molecules using AutoDock 4.2 and AutoDock Vina. Using computational approaches will help to improve lead identification and screening. Herein, we have retrieved six phytochemicals from published literature and investigated their inhibitory effect with Wnt-associated signaling proteins. Authentication of phytocompounds and Wnt-associated signaling proteins was done using AutoDock.4.2.

Conclusions
The results are screened based on the number of hydrogen bonds, binding energy, and interacting amino acids. The Isoorientin, luteolin, and Chrysophanol get the highest binding energy with target receptors. The binding energy is calculated with all target receptors from the range of − 6.0 to − 8.9 kcal/mol. The In-silico drug likeliness properties are predicted to be the best interacting compounds based on Lipinski Rule of 5 and ADMET analysis. Hence, we propose that Isoorientin, luteolin, and Chrysophanol are the potential inhibitors of Wnt signaling inhibitors, and preclinical studies are needed to confirm the promising therapeutic ability of colorectal cancer.
Prediction of the relationship of cesarean section scar niche and postmenstrual spotting: is there any relation?
Authors: Bandry Kirollos Wagdy , Abou-Taleb Hisham , Seifeldein Gehan S. , Taha Mohamad Gaber , Qenawy Omran Khodary 
Published: January 2022

Abstract
Background
Postmenstrual spotting has recently been related to a discontinuation of the myometrium at the site of a previous cesarean section called "CS scar niche". There was no consensus regarding the gold standard method for the assessment of the niche. Recently, Magnetic resonance imaging (MRI) has shown promise in the evaluation of the niche. Our study aims to assess the role of MRI in the evaluation of the CS scar niche characters and its association with post-menstrual spotting.

Results
A total of 65 patients with CS niche were prospectively included in this study and subdivided into two groups, according to presence or absence of postmenstrual spotting (Group A; 34 patients with postmenstrual spotting and Group B; 31 patients without spotting). All patients were examined using a 1.5 T MRI unit. CS scar niche volume was significantly higher among women with post-menstrual spotting (0.57 ± 0.07 vs. 0.07 ± 0.05 (cm3); P < 0.001). Also, women with post-menstrual spotting have significantly higher scar length (9.38 ± 3.06 vs. 5.02 ± 2.10 (mm); P < 0.001), scar depth (6.95 ± 3.16 vs. 3.23 ± 0.99 (mm); P < 0.001), scar width (15.78 ± 3.94 vs. 9.87 ± 1.84 (mm); P < 0.001) in comparison to those without post-menstrual spotting.
Scar depth (> 7.4 mm) had 81% sensitivity and 97% specificity for prediction of post-menstrual spotting with overall accuracy was 88.7%. While scar width (> 12.8 mm) had 71% sensitivity and 97% specificity for prediction of post-menstrual spotting with overall accuracy was 83.3%. Scar volume (> 0.15 cm3) had 97% sensitivity and 100% specificity for prediction of post-menstrual spotting with overall accuracy was 98.4%.

Conclusion
MRI measures (CS scar volume, depth, and width) are predictors for postmenstrual spotting in patients with CS scar niche, and scar volume is the most powerful predictor.
The effect of therapeutic exercise and vegan diet on pain and quality of life in young female patients with chronic non-specific neck pain
Authors: Torlak Mustafa S. , Gonulalan Gulsum , Tufekci Osman , Nazli Merve S. , Atici Emine 
Published: January 2022

Abstract
Background and purpose
In recent years, dietary practices have begun to be used in painful conditions. This study aimed to investigate the effect of a vegan diet and therapeutic exercise in patients with chronic non-specific neck pain.

Materials and methods
A total of 45 young female patients with chronic non-specific neck pain, aged 18–25 years, participated in the study. Body mass index and body fat percentage were measured with bioelectrical impedance analysis. Pain severity was assessed using the Visual Analogue Scale, quality of life with the short form-36 scale, kinesiophobia with the Tampa scale of kinesiophobia and neck disability with the Neck Disability Index.

Results
The pain severity reduced in the diet group and exercise group after treatment (p = 0.001). After treatment, Neck Disability Index score decreased in the diet group and exercise group (p = 0.001). Tampa scale of kinesiophobia score decreased in the diet group and exercise group (p = 0.001). The eight domains of the short form-36 scale score increased in the diet group and exercise group (p < 0.05). No difference was found in the body mass index and fat percentage in all groups before and after treatment (p˃ 0.05).

Conclusion
A vegan diet and therapeutic exercise are beneficial to patients with chronic non-specific neck pain in terms of pain severity and quality of life.
Two years of SARS-CoV-2 infection (2019–2021): structural biology, vaccination, and current global situation
Authors: Ahmad Waqar , Shabbiri Khadija 
Published: January 2022

AbstractThe deadly SARS-CoV-2 virus has infected more than 259,502,031 confirmed cases with 5,183,003 deaths in 223 countries during the last 22 months (Dec 2019–Nov 2021), whereas approximately 7,702,859,718, vaccine doses have been administered (WHO: https://covid19.who.int/) as of the 24th of Nov 2021. Recent announcements of test trial completion of several new vaccines resulted in the launching of immunization for the common person around the globe highlighting a ray of hope to cope with this infection. Meanwhile, genetic variations in SARS-CoV-2 and third layer of infection spread in numerous countries emerged as a stronger prototype than the parental. New and parental SARS-CoV-2 strains appeared as a risk factor for other pre-existing diseases like cancer, diabetes, neurological disorders, kidney, liver, heart, and eye injury. This situation requires more attention and re-structuring of the currently developed vaccines and/or drugs against SARS-CoV-2 infection. Although a decline in COVID-19 infection has been reported globally, an increase in COVID-19 cases in the subcontinent and east Mediterranean area could be alarming. In this review, we have summarized the current information about the SARS-CoV-2 biology, its interaction and possible infection pathways within the host, epidemiology, risk factors, economic collapse, and possible vaccine and drug development.
Visual Histories of Sex
Authors: Bauer Heike , Pappademos Melina , Sutton Katie , Tucker Jennifer 
Published: January 2022

AbstractIncreased access to visual archives and the proliferation of digitized images related to sexuality have led a growing number of scholars in recent years to place images and visual practices at the center of critical historical inquiries of sexual desire, subjectivity, and embodiment. At the same time, new critical histories of sexual science serve both to expand the temporal and geographical frames for investigating the historical relationships of sex and visual production, and to generate new lines of inquiry and reshape visual studies more broadly. The contributors to this issue invite us to ask: What new questions and challenges for the study of sex and sexual science are posed by critical studies of the visual? How are new visual methodologies that focus on archives changing the contours of historical knowledge about sex and sexuality? What—and where—are new methodologies still needed? “Visual Archives of Sex” aims to illuminate current research that centers visual media in the history of sexuality and that interrogates contemporary historiographies.
Bikinis and Other Atomic Incidents: The Synthetic Life of the Nuclear Pacific
Authors: Xiang Sunny 
Published: January 2022

AbstractThis article examines a range of mid-twentieth-century American fashions, particularly women’s intimate wear, that went by the name of “bikini.” In doing so, it identifies the bikini as an overt but unremarkable incident of racial and colonial violence. Treating the nuclear Pacific as conspicuously incidental in mainstream atomic culture enables new insights on the visual interplay between white femininity and primitive sexuality—an interplay that, the author argues, was integral to establishing domestic virtue and modern living as atomic age touchstones of “peace.” To elaborate on this argument, this article tracks the bikini’s achievement of propriety within a broader fashion revolution spurred by the use of high-tech fibers in swim, sleep, and support garments. It shows how an atomic ideal of “nature” arose from an imperial desire for security in the face of extreme risk—both the global risk of nuclear war and the domestic risk of sexual promiscuity.
Homemade Pornography and the Proliferation of Queer Pleasure in East Germany
Authors: Frackman Kyle 
Published: January 2022

AbstractLike other Eastern Bloc countries, East Germany sought to control even its citizens’ leisure time in the 1960s and 1970s, with the goal of making it useful or at least not subversive to state interests. Certain hobbies, like amateur photography, found support from the state in the form of increased access to equipment and supplies. Other scholarship has shown that sex was a locus of privacy and self-assertion in a society with a high degree of surveillance and state control. Focusing on a previously unanalyzed collection of erotic photographs of men, the article argues, first, that the support for amateur photography makes the state an unwitting participant in the creation and circulation of these illicit images and, second, that the images are an archive of queer men’s self-presentation and critique in a context wherein their existence and affect are transgressive.
Teaching the History of Sexuality with Images
Authors: Jones Sarah 
Published: January 2022

Abstract
This article outlines how an in-depth engagement with visual archives has transformed the author’s pedagogical practice. It argues that working with visual sources like photographs and illustrations offers students important opportunities to develop key academic skills, and to think critically about archives and sources. It details how working with such rich materials makes space for personal reflection and discovery, especially for students engaging with histories of sex and sexuality for the first time. Outlining the strengths of this approach, it explores some of the tensions and obstacles inherent in doing this kind of work—discussing, for example, the ethical dilemmas faced when reproducing and disseminating sexualized images in the classroom, the complexities of handling student reactions, and the activities students and the instructor have created to negotiate these issues.
Seeking Pleasure in Peril: Male Same-Sex Relations during the Cultural Revolution
Authors: Kang Wenqing 
Published: January 2022

Abstract
This article is part of a larger research project that traces the history of male same-sex relations in China during the Mao era, a topic on which virtually no scholarship is currently available. The Chinese government named the Cultural Revolution (1966–76) “ten years of turmoil” in its aftermath. Stories circulate widely about men who were labeled as sodomites, humiliated and tortured in public, and sentenced to hard labor; some reportedly were beaten to death or committed suicide during this period. Using oral history and archival cases collected by the author, this article complicates this narrative about the Cultural Revolution by documenting different experiences of sexual awakening, ingenuity, and resilience of those men as well as their fear, misfortune, and tribulations. Despite all the risks of being arrested, interrogated, and disciplined by the authorities, clandestine sex between men persisted in both private and public spaces throughout this tumultuous period.
The Making ofHomo Socialist: The Discursive Analysis of the Ideological Production of Class in China, 1949–1976
Authors: Cheng Xiuying 
Published: January 2022

AbstractBased on a critique of the history project titled “Oral History of Peasants’ Ordinary Life in the Revolutionary Era of China,” this article provides an analysis of class ideology production from Land Reform Movement to the Cultural Revolution in China. Thirty years of socialist construction in China was based on the craft of making the Homo Socialist. The focus here is on how personal experiences were transformed into state-endorsed conduct via the discourse of class and class struggle. Over the course of the sociopolitical transformations leading to the Cultural Revolution, “class” changed from a socioeconomic designation to a political behavioral metaphor, and in the end a purely symbolic gesture; personal experiences were transformed from hallmarks of class privilege to virtual identification with imagined class struggle. And the peasants went from being “owners of bitterness” to “debtors of bitterness” on the way to becoming “sinners of the revolution”—who gradually submitted themselves to the regime in the name of revolution, liberation, and redemption. These transformations were realized through discursive practices connecting personally embodied experiences with the abstract Marxist theory of class and class struggle. Examining the shifting nature of class ideology production helps to explain how the Chinese Communist Party understood the effects of its governance and how people found class ideology meaningful to them, even when it reached the point of absurdity.
Prognostic Factors Independently Associated With Improved Progression-Free Survival After Surgical Resection in Patients With Spinal Cord Astrocytomas: An Institutional Case Series
Authors: Helal Ahmed , Alvi Mohammed Ali , Everson Megan , Mikula Anthony L. , Cohen Cohen Salomon , Bydon Mohamad , Krauss William E. , Clarke Michelle J. 
Published: January 2022

BACKGROUND:
Spinal astrocytomas are rare tumors in which the extent of resection and adjuvant therapy remain controversial. A number of new molecular markers are used, but their utility in spinal cord tumors remains unclear.

OBJECTIVE:
To determine prognostic indicators of progression-free survival (PFS) in patients with spinal astrocytomas.

METHODS:
A retrospective chart review identified all patients managed at a single institution for spinal cord astrocytomas between 1999 and 2019. Data collected included baseline demographics, presenting signs and symptoms, tumor size, operative outcomes, and adjuvant treatment. Pathological data including histopathological grade, proliferative index, and molecular profile were collected. Duration of follow-up, presence of tumor progression, and status at last follow-up were documented. Univariate and multivariate analyses were performed to determine predictors of PFS.

RESULTS:
Seventy-five patients were included in our study with an average age of 42 ± 17 yr. The thoracic spine was the most commonly involved spinal segment (50 patients), and most patients had grade I or grade II tumors (50 patients). On univariate analysis, gross total resection (GTR), lower tumor grade, and low Ki-67 index were associated with lower tumor progression (P-values .01, .04, and .00013, respectively). On multivariate Cox regression analysis, GTR, adjuvant chemotherapy and radiation, and low Ki-67 index were independent predictors of PFS (P-values .009, .011, and .031, respectively).

CONCLUSION:
In spinal astrocytomas, GTR, adjuvant therapy, and low Ki-67 are independently associated with improved PFS. These data may help guide management of these tumors and provide important prognosticating information.
Dynamic configurations of meiotic DNA-break hotspot determinant proteins
Authors: Chuang Yu-Chien , Smith Gerald R. 
Published: January 2022

ABSTRACT
Appropriate DNA double-strand break (DSB) and crossover distributions are required for proper meiotic chromosome segregation. Schizosaccharomyces pombe linear element proteins (LinEs) determine DSB hotspots; LinE-bound hotspots form three-dimensional clusters over ∼200 kb chromosomal regions. Here, we investigated LinE configurations and distributions in live cells using super-resolution fluorescence microscopy. We found LinEs form two chromosomal structures, dot-like and linear structures, in both zygotic and azygotic meiosis. Dot-like LinE structures appeared around the time of meiotic DNA replication, underwent dotty-to-linear-to-dotty configurational transitions and disassembled before the first meiotic division. DSB formation and repair did not detectably influence LinE structure formation but failure of DSB formation delayed disassembly. Recombination-deficient LinE missense mutants formed dot-like, but not linear, LinE structures. Our quantitative study reveals a transient form of LinE structures and suggests a novel role for LinE proteins in regulating meiotic events, such as DSB repair. We discuss the relationship of LinEs and the synaptonemal complex in other species.
This article has an associated First Person interview with the first author of the paper.
Problems of financing sources for environmental protection in strategic documents of the European Union and Poland in the new financial perspective for 2021–2027
Authors: Hajdys Dagmara 
Published: January 2022

Motivation: Over the past two decades, the world, and Poland with it, has faced a huge challenge of transforming its economy towards climate neutrality. The observed effects of climate change, such as abrupt weather changes (prolonged droughts, sudden downpours), increase in average temperatures, environmental pollution, call for systemic and social actions. It should be clearly noted that the responsibility for actions aimed at environmental protection is borne not only by public administration (central and local government), but also by the private sector, as the one using and influencing the environment. The year 2020 brought an unexpected global health crisis caused by the SARS-CoV-2 virus. MFF procedures developed up to that time were modified. The COVID-19 pandemic significantly affected the preparation of legislation, programs, and rules for obtaining funds from them for project implementation. Many legislative works have been postponed, causing delays. The fact of the pandemic has led to the implementation of the Instrument for Reconstruction and Enhancing Resilience, which includes large-scale financial support for public investments and areas such as green and digital projects, in addition to the regular financial perspective. Support will be provided in the form of loans (EUR 360 billion) and grants (EUR 312.5 billion).
Aim: The aim of the study is to compare the financial instruments covered by the European Union financial perspectives 2021–2027 with 2014–2020 in the context of environmental funding sources in Poland.
Results: Both in the financial perspective 2014–2020 and the new one for 2021–2027, environmental protection issues are one of the main priorities. The continuity of previous structural funds has been preserved and supplemented with new instruments in response to the unprecedented socio-economic situation that has arisen as a result of the global health crisis caused by the SARS-CoV-2 pandemic. As a result of negotiations, EUR 76 billion will be made available to Poland under the EU’s cohesion policy and the Fund for Equitable Transformation, whereas in the previous one the amount was EUR 85.2 billion. The allocation of funds and the directions of spending will not only result from Poland’s development needs, but also (and perhaps above all) from the modified priorities of the Union as a response to the health situation of the EU community after the pandemic and the continuation of existing activities related to research, innovation, digitization, climate and the environment. The launch of individual programmes will allow ongoing analysis and evaluation of both the solutions adopted in strategic documents and their effects.
Smart legislative regulation: investigation of the behavior of the Czech RIA Committee
Authors: Janáček Julius , Pacovský Libor , Jílková Jiřina , Jílek Jindřich 
Published: January 2022

Motivation: This article studies the behavior of the Czech Regulatory Impact Assessment (RIA) Committee during the years between 2013–2018. This institution assesses RIAs of new laws and regulations which are in the process of ratification.
Aim: The main aim was to find if the legislative change of February 3, 2016 had a direct impact on the decision-making of the Committee. Further, we ask whether there are other distinct patterns in the behavior of Czech RIA Committee members. Specifically, do the RIA Committee’s verdicts become more negative with time? We also investigate the level of independence of the Committee. In our analysis we used basic statistics: Chi-Square test of independence and regression analysis. To complete our study, we used data from a questionnaire which was distributed among RIA Committee members.
Results: In our analysis we found that the legislative change did not have a direct immediate effect on the RIA Committee of the Czech Republic. However, we discovered that the RIA Committee has lost most of its independence and power in the six years of its existence. This change was gradual and most likely catalyzed by pressure from politicians. Further, voting per rollam yielded more positive results. We also discovered an institution whose RIA Committee verdicts differed significantly. Based on the findings of our research, we offer recommendations to the RIA Committee and other institutions with a similar purpose.