bluuebunny/crossref_metadata_2025_split huggingface dataset:
Idiopathic granulomatous mastitis after mRNA vaccination against COVID-19: a possible association?
Authors: Vall Elisenda , Araya Vicente , Tortajada Lidia , Escobedo Vanessa , Nogueiras Rosa , del Riego Javier 
Published: February 2025

Abstract
Idiopathic granulomatous mastitis (IGM) is an uncommon benign disease thought to have an autoimmune origin. After massive vaccination against COVID-19, mRNA vaccines have been associated with various possible adverse effects. Among those involving the breast, the most common are ipsilateral axillary lymphadenopathies and transient breast oedema. We present the case of a young woman who developed IGM after mRNA vaccination against COVID-19. We describe the clinical and imaging findings and management of this case, discussing the evidence for a possible link between vaccination and the development of this uncommon inflammatory process and underlining the importance of including this entity in the differential diagnosis in this scenario.
Impact of valvulo-vascular haemodynamics on left ventricular remodelling and the prevalence of discordant moderate aortic stenosis
Authors: Ali Mulham , Tastet Lionel , Mogensen Nils Sofus Borg , Diederichsen Axel , Shen Mylène , Arsenault Marie , Møller Jacob Eifer , Øvrehus Kristian Altern , Bédard Elisabeth , Lindholt Jes Sanddal , Lambrechtsen Jess , Steffensen Flemming Hald , Urbonaviciene Grazina , Haujir Amal , Pellikka Patricia A , Pibarot Philippe , Clavel Marie-Annick , Dahl Jordi Sanchez 
Published: February 2025

Abstract

Aims
This study aims to describe the prevalence of discordant mild/moderate aortic stenosis (AS) in a population-based study and to identify the mechanisms that lead to reduced stroke volume (SV) and discordant moderate AS.

Methods and results
Discordant high-gradient (HG)-mild AS, defined as AVA &gt; 1.5 cm2 and mean pressure gradient (MG) of 20–40 mmHg, and discordant low-gradient (LG) moderate AS, defined as AVA 1.0–1.5 cm2 and MG &lt; 20 mmHg, were assessed in 883 individuals from the DANCAVAS screening study with aortic valve calcification and 257 individuals form the PROGRESSA study excluding those with left ventricular (LV) ejection fraction &lt; 50%. In the DANCAVAS cohort, 150 men had mild/moderate AS of which 34% had discordance between MG and AVA, representing 66% with moderate AS. Among 262 patients in the combined cohort, 39% had discordant LG-moderate AS and 6% discordant HG-mild AS. Compared with concordant mild and moderate AS, individuals with discordant LG-moderate AS were more likely to present with LV concentric remodelling geometry (26 vs. 33 vs. 45%, P &lt; 0.001), increased valvulo-arterial impedance (3.3 ± 0.7 vs. 3.6 ± 0.5 vs. 4.1 ± 0.7 mmHg/mL/m2, P &lt; 0.001), and reduced systemic arterial compliance (SAC) (0.74 ± 0.22 vs. 0.81 ± 0.22 vs. 0.64 ± 0.18 mL/m2/mmHg, P &lt; 0.001). Factors associated with SV index were relative wall thickness, LV end-diastolic diameter index, SAC, and LV remodelling pattern.

Conclusion
Discordant moderate AS is common, accounting for two-thirds of patients with moderate AS in the general male population. Patients with discordant LG-moderate AS have predominantly a concentric remodelling pattern with reduced SV. Reduced SV index was associated with signs of reduced vascular compliance, suggesting that altered vascular properties drive differences in remodelling patterns and discordant moderate AS.
May Measurement Month 2022: an analysis of blood pressure screening results from Ghana
Authors: Twumasi-Ankrah Betty , Kiddy-Kodua Joseph O , Aniagyei Marian , Adu – Adadey Martin , Gatorwu Sylvanus , Beaney Thomas , Kerr Gabriele , Poulter Neil R , Osei -Agyemang Comfort , Myers-Hansen Gustavus A 
Published: February 2025

Abstract
The May Measurement Month (MMM) campaign was carried out in Ghana in 2022 with the aim of raising awareness of raised blood pressure (BP). Here, we report on the findings of the campaign. Adults aged ≥ 18 years were recruited opportunistically at Greater Accra, Eastern, Central and Ashanti Regions of Ghana. Three seated BP readings were taken for each participant, along with completing a questionnaire on demographics, lifestyle factors, and comorbidities. Hypertension was defined as a systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg or being on antihypertensive medication. Controlled BP was defined as being on antihypertensive medication with a BP &lt;140/90 mmHg. Multiple imputation was used to estimate any missing BP readings. In total, 3654 were screened, with a mean age of 38.3 years and 14.8% of whom were female. Of all participants, 1171 (32.0%) had hypertension, of whom 125 (10.7%) were aware, and 118 (10.1%) were on antihypertensive medication. Of those on antihypertensive medication, 23 (19.5%) had controlled BP, and of all participants with hypertension, 2.0% had controlled BP. The MMM campaign in Ghana identified a high proportion of participants with either untreated or inadequately treated hypertension. It is important to note that the annual BP screening campaign is a means to create awareness of the need to get screened and also identifies large numbers of individuals with raised BP.
Socio-geographical factors associated with cardiac rehabilitation participation after percutaneous coronary intervention: A registry-based cohort study from France
Authors: Quattrone Filippo , Lesaine Emilie , Domecq Sandrine , Legrand Jean-Pierre , Miganeh Hadi Sahal , Coste Pierre , Couffinhal Thierry , Saillour-Glénisson Florence ,   ACIRA investigators, Pierre Fournier , Philippe Jarnier , Nicolas Delarche , Jean-Luc Banos , Nicolas Marque , Bernard Karsenty , JeanMarie Perron , Jean-Louis Leymarie , Akil Hassan , Bernard Larnaudie , Guillaume Laplace 
Published: February 2025

Abstract

Aims
Cardiac rehabilitation (CR) after percutaneous coronary intervention (PCI) for acute (ACS) or chronic (CCS) coronary syndrome is underutilised worldwide. The determinants of underuse are not fully understood. Using real-world data, this study explored the effect of socio-geographical factors on CR participation.

Methods
Patients from the Aquitaine region (France) who underwent PCI between 2017 and 2019 were selected from a regional PCI register. Their 1-year CR participation was tracked using the French hospital database. Associations between CR participation and socio-geographical factors, (social deprivation, general practitioner accessibility, and distance to the nearest CR centre) were assessed through logistic regression mixed models at 1 and 3 months in ACS, and at 3 and 6 months in CCS.

Results
Among the 19,002 patients, 5,073 (26.7%) participated in CR (ACS: 4,071, 33.0%; CCS: 1,002, 15.0%). A CR centre distance &gt;25 km reduced participation at 3 months in ACS patients (OR = 0.83, 95% CI: 0.70–0.99, p = 0,023), but not at 1 month after PCI. CCS patients from most advantaged areas were more likely to participate in CR at 3 (OR = 0.62, 95% CI: 0.44–0.88, p = 0.002) and 6 months (OR = 0.59, 95% CI: 0.42–0.82, p &lt; 0.001). General practitioner accessibility did not affect participation.

Conclusion
Post-PCI CR participation was low. Proximity to CR centres promoted participation for ACS patients, while CR usage correlated with higher socio-economic status for CCS patients. These findings highlight socio-geographical inequalities in CR access, providing a basis for targeted interventions, such as telerehabilitation or expanded coverage.
Unraveling the Impact of Marine Heatwaves on the Eukaryome of the Emblematic Mediterranean Red Coral Corallium rubrum
Authors: Prioux Camille , Ferrier-Pagès Christine , del Campo Javier , Guillou Laure , Estaque Tristan , Allemand Denis , Tignat-Perrier Romie 
Published: February 2025

Abstract
Global warming is intensifying heatwaves worldwide, leading to more frequent and severe temperature extremes. This study investigates the impact of the unprecedented 2022 Mediterranean heatwaves on the coral eukaryome, which has received little attention despite its known importance to coral holobiont functioning. Fifty-six colonies of the iconic red coral Corallium rubrum from the Mediterranean Sea were collected at different sites, depths and health states. The microeukaryotic communities were analyzed using an 18S rRNA gene metabarcoding approach. Primers were designed to reduce amplification of the 18S rRNA gene sequences of the red coral while being universal for amplification of microeukaryotes. Our results showed that the red coral eukaryome was dominated by Dino-Group I, Licnophoridae and Labyrinthulomycetes in the control sites that were not affected by the heat waves. In the heat-affected colonies, the composition of the coral eukaryome changed, with the relative abundances of Ephelotidae, Exobasidiomycetes, Corallicolidae, Labyrinthulomycetes and/or the epibionts Phaeophyceae increasing depending on the intensity of heat stress experienced by the colonies. It was thus possible to link colony health to changes in the eukaryome. Finally, we illustrated putative interactions (competition, predator–prey relationship and parasitism) occurring within C. rubrum eukaryome that could explain the compositional changes observed in the microeukaryotic communities under heat stress. Our findings improve our understanding of the ecological effects of heatwaves on marine ecosystems.
PAMS: The Perseus Arm Molecular Survey – I. Survey description and first results
Authors: Rigby Andrew J , Thompson Mark A , Eden David J , Moore Toby J T , Mutale Mubela , Peretto Nicolas , Plume Rene , Urquhart James S , Williams Gwenllian M , Currie Malcolm J 
Published: February 2025

Abstract
The external environments surrounding molecular clouds vary widely across galaxies such as the Milky Way, and statistical samples of clouds are required to understand them. We present the Perseus Arm Molecular Survey (PAMS), a James Clerk Maxwell Telescope (JCMT) survey combining new and archival data of molecular-cloud complexes in the outer Perseus spiral arm in 12CO, 13CO, and C18O (J=3–2). With a survey area of ∼8 deg2, PAMS covers well-known complexes such as W3, W5, and NGC 7538 with two fields at ℓ ≈ 110○ and ℓ ≈ 135○. PAMS has an effective resolution of 17 arcsec, and rms sensitivity of Tmb = 0.7–1.0 K in 0.3 km s−1 channels. Here we present a first look at the data, and compare the PAMS regions in the Outer Galaxy with Inner Galaxy regions from the CO Heterodyne Inner Milky Way Plane Survey (CHIMPS). By comparing the various CO data with maps of H2 column density from Herschel, we calculate representative values for the CO-to-H2 column-density X-factors, which are $X_\mathrm{^{12}CO\, (3-2)}$ = 4.0 × 1020 and $X_\mathrm{^{13}CO\, (3-2)}$ = 4.0 × 1021 cm−2 (K km s−1)−1 with a factor of 1.5 uncertainty. We find that the emission profiles, size–linewidth, and mass–radius relationships of 13CO-traced structures are similar between the Inner and Outer Galaxy. Although PAMS sources are slightly more massive than their Inner Galaxy counterparts for a given size scale, the discrepancy can be accounted for by the Galactic gradient in gas-to-dust mass ratio, uncertainties in the X-factors, and selection biases. We have made the PAMS data publicly available, complementing other CO surveys targeting different regions of the Galaxy in different isotopologues and transitions.
CHEXANET: A novel approach to fast-tracking disequilibrium chemistry calculations for exoplanets using neural networks
Authors: Vojtekova Antonia , Waldmann Ingo , Yip Kai Hou , Merín Bruno , Al-Refaie Ahmed Faris , Venot Olivia 
Published: February 2025

Abstract
In the rapidly evolving field of exoplanetary science with missions like JWST and Ariel, there is a pressing need for fast and accurate simulations of disequilibrium chemistry in exoplanet atmospheres. Methods which assume chemical equilibrium simplify calculations but fail to capture the more complex chemical dynamics observed in actual exoplanets. Accurate estimations require complex kinetic codes that are time-intensive due to the need to solve ordinary differential equations. Given an extensive parameter space that needs to be explored to calculate forward models, kinetic codes will become a significant bottleneck, especially when used to match observations or in retrieval processes. We introduce CHEXANET, a novel U-Net-based neural network architecture designed to efficiently simulate disequilibrium chemistry in exoplanetary atmospheres. By utilising the thermochemical equilibrium state of a hot-Jupiter’s atmosphere as an initial condition, which computes in seconds, alongside a set of initial parameters such as the C/O ratio, the network effectively learns to predict the atmosphere in disequilibrium. It significantly enhances computational efficiency, reducing the prediction time for atmospheric disequilibrium states to just one second per atmosphere on a standard personal computer—over a hundred times faster than traditional kinetic models like FRECKLL.
Representation learning for fast radio burst dynamic spectra
Authors: Kuiper Dirk , Contardo Gabriella , Huppenkothen Daniela , Hessels Jason W T 
Published: February 2025

Abstract
Fast radio bursts (FRBs) are millisecond-duration radio transients of extragalactic origin, with diverse time-frequency patterns and emission properties that require explanation. With one possible exception, FRBs are detected only in the radio, analyzing their dynamic spectra is therefore crucial to disentangling the physical processes governing their generation and propagation. Furthermore, comparing FRB morphologies provides insights into possible differences among their progenitors and environments. This study applies unsupervised learning and deep learning techniques to investigate FRB dynamic spectra, focusing on two approaches: Principal Component Analysis (PCA) and a Convolutional Autoencoder (CAE) enhanced by an Information-Ordered Bottleneck (IOB) layer. PCA served as a computationally efficient baseline, capturing broad trends, identifying outliers, and providing valuable insights into large datasets. However, its linear nature limited its ability to reconstruct complex FRB structures. In contrast, the IOB-augmented CAE excelled at capturing intricate features, with high reconstruction accuracy and effective denoising at modest signal-to-noise ratios. The IOB layerâ&#x80;&#x99;s ability to prioritize relevant features enabled efficient data compression, preserving key morphological characteristics with minimal latent variables. When applied to real FRBs from CHIME, the IOB-CAE generalized effectively, revealing a latent space that highlighted the continuum of FRB morphologies and the potential for distinguishing intrinsic differences between burst types. This framework demonstrates that while FRBs may not naturally cluster into discrete groups, advanced representation learning techniques can uncover meaningful structures, offering new insights into the diversity and origins of these bursts.
Virus-derived siRNA: Coronavirus and influenza virus trigger antiviral RNAi immunity in birds
Authors: Wu Yaotang , Liu Peng , Zhou Jie , Fu Mei , Wang Chenlu , Xiong Ningna , Ji Wenxin , Wang Zhisheng , Lin Jian , Yang Qian 
Published: February 2025

Abstract
RNA interference (RNAi) is a key antiviral immune mechanism in eukaryotes. However, antiviral RNAi in vertebrates has only been observed in cells with poor interferon systems or in viral suppressors of RNAi (VSR) deficiency virus infections. Our research discovered that infecting macrophages with wild-type coronavirus (Infectious bronchitis virus, IBV) and influenza viruses (Avian influenza virus, AIV) can trigger RNAi antiviral immunity and produce a certain amount of virus-derived siRNA (vsiRNA). These vsiRNAs have an inhibitory effect on the virus and carry out targeted silencing along the Dicer-Ago2-vsiRNA axis. Notably, these vsiRNAs are distributed throughout the virus's entire genome, with a predilection for A/U at the 5′ and 3′ termini of vsiRNA. In addition, Dicer cleavage produces vsiRNA based on the RWM motif, where R represents A/G, W represents A/C, and M represents A/U. We also discovered that avian LGP2 and MDA5 proteins positively impact the expression of the Dicer protein and the Dicer subtype “DicerM.” Most importantly, the PS-vsiRNA plasmid combined with nanomaterial polyetherimide (PEI) showed excellent anti-virus activity in specific-pathogen-free (SPF) chickens. These findings show that RNA viruses trigger the production of the vsiRNA in avian somatic cells, which is of great significance for the application of therapeutic vaccines.
Autologous Hematopoietic Stem Cell Transplantation for Non-AL Amyloidosis Monoclonal Gammopathy of Renal Significance
Authors: Liu Mengnan , Zhao Liang , Guo Jinzhou , Chen Wencui , Wu Xiaomei , Xu Weiwei , Huang Xianghua 
Published: February 2025

Abstract

Background
The treatment strategy for non-AL amyloidosis monoclonal gammopathy of renal significance (MGRS) remains unstandardized. Autologous hematopoietic stem cell transplantation (ASCT) has shown favorable results in a limited number of studies.

Methods
This single-center, retrospective case-control study included non-AL amyloidosis MGRS patients diagnosed between February 2012 and July 2024; these patients were divided into the ASCT group and non-ASCT group. Baseline characteristics, ASCT characteristics and complications, treatment responses, survival outcomes, and risk factors for progression-free survival (PFS) were analyzed.

Results
A total of 53 patients with non-AL amyloidosis MGRS were enrolled in this study, comprising 23 patients who received ASCT and 30 patients who did not receive ASCT. The baseline characteristics were comparable between the ASCT and non-ASCT groups, with exceptions of serum albumin and C3 levels. The median OS and renal survival were not reached in either group. The median PFS was significantly longer in the ASCT group compared to the non-ASCT group (58.4 vs 16.4 months, P=0.004). The ORR and deep response rates of the ASCT group were higher than those of the non-ASCT group, both in hematological and renal responses. In the ASCT group, 18 patients (78.3%) achieved a hematological VGPR or better, and 21 patients (91.3%) achieved a renal PR or better after transplantation. Moreover, the ASCT group exhibited higher long-term cumulative incidences of OS and renal survival. The toxicity of ASCT was manageable, and no transplantation-related deaths occurred. There was no statistically significant difference in the median PFS between MIDD and LCPT (P=0.539). High serum albumin level at diagnosis, and hematological response ≥VGPR after ASCT were protective factors of PFS.

Conclusions
This study confirmed that ASCT was an effective and safe treatment for patients with non-AL amyloidosis MGRS, thereby offering long-term hematological remission and survival benefits.
Cutting edge deep-learning based tools for metagenomic research
Authors: Karin Eli Levy , Steinegger Martin 
Published: February 2025

Abstract
Recent years have seen incredible progress in the development of deep-learning (DL) tools for the analysis of biological data, with the most prominent example being AlphaFold2 for accurate protein structure prediction. DL-based tools are especially useful for identifying patterns and connections within sparsely labeled datasets. This makes them essential for the analysis of metagenomic data, which is mostly unannotated and bears little sequence similarity to known genes and proteins. In this review, we chose to present twelve tools which we deem as offering novel capabilities for metagenomic analysis by utilizing interesting DL techniques. This review is thus intended to be a solid starting point for any data scientist looking to apply advanced methods to explore metagenomic datasets. For each DL-based tool, we present its computational principles, followed by relevant examples of its application where possible and a note on its limitations.
“Dead Giveaway”
Authors: Austin Michael L. 
Published: February 2025

Abstract
This chapter examines a number of auto-tuned viral videos that were popular primarily in the early 2010s, paying particular attention to videos created by the Gregory Brothers. In these videos, Black people are misrepresented as “hilarious black neighbors,” reducing them to caricatures that harken back to blackface minstrelsy of the 1800s and blaxploitation films of the mid-twentieth century. The chapter also discusses a number of important ethical issues regarding the sampling, manipulation, and exploitation of the voices of marginalized communities, especially people of color and those with mental health issues, especially when these practices result in misrepresentations of these communities.
National Parliaments as a Global Institution
Authors: 9780192655684  , Alasuutari Pertti 
Published: February 2025

Abstract
This book scrutinizes national parliaments as an institution: how the current world order comprising national legislatures evolved, how the parliaments work, and how they form a global network or field in that there is a travel of ideas and information between them. It shows that in their structures and practices, legislatures are very similar. Phrases used, say, in the opening words of a session can be verbatim copies of those in other parliaments. Through such isomorphic, invariant practices, legislatures symbolize, sanctify, and naturalize the nation-state as the component part of world society. The global standardization of parliamentary practices has also constituted what is the world over understood by politics, radiating to the forms that political organization into parties, ideologies, and movements has assumed. Furthermore, the sacred principles observed constitute parliamentary practices as rituals. These principles are honored in frontstage sessions, whereas bargaining between conflicting group interests takes place in backstage occasions. Yet frontstage performances are important because they frame the issues and justify the decisions taken by commonly approved virtues and principles. In addition to passing (or proposing) laws, national parliaments legitimate rule and serve as switchboards in global governance and travel of ideas.
The Plan
Authors: Jackson Ashley , Stewart Andrew 
Published: February 2025

Abstract
This chapter defines the British ‘plan’ to regenerate national power, close the gap on America and the Soviet Union, and secure the Empire’s future. That plan had seven interlocking main elements. There was the need to assure the continuing unity of the Empire and to resist Soviet expansion and influence. Pursuing this element of the plan, the British had to accept the fact that America might abandon Europe as it had done in 1918, placing enormous burdens of leadership, responsibility, and cost upon their shoulders. A linked element of the plan was to prepare to meet not only traditional imperial defence requirements but to deter the Soviets and even face them on the battlefield. This meant using the military resources of the entire Empire and acquiring an independent nuclear capability. The British also planned to foster the re-establishment of European power in the international system, and to replenish British economic strength. Connected to this was another element of the plan, the need for cooperation with Washington in order to harness American support for British recovery and forward Anglo-American leadership of the world. This would underpin the new United Nations world organization, which itself was to be a vehicle for the global leadership of the ‘Big Three’ powers. The plan’s final element was the renovation of the Empire, materially through enlightened policies of colonial development and welfare, and stylistically through pugnacious, optimistic presentations of Britain’s modernized imperial mission as a boon for the people of the Empire and the well-being of the world.