bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KETERSEDIAAN PRASARANA DAN SARANA PERMUKIMAN NELAYAN DI KELURAHAN LAKOLOGOU KECAMATAN KOKALUKUNA KOTA BAUBAU
Authors: Himan Muhamad , Syarif Muh. , Rahim Manat 
Published: April 2022

Penelitian ini bertujuan mengidentifikasi dan menganalisis kondisi lingkungan permukiman di tinjau dari aspek fisik (prasarana dan sarana), sosial dan ekonomi masyarakat di Kelurahan Lakologou Kecamatan Kokalukuna Kota Baubau berdasarkan Standar Pelayanan Minimal (SPM) permukiman. Penelitian ini dilaksanakan di Kelurahan Lakologou Kecamatan Kokalukuna Kota Baubau. Data yang digunakan adalah data kependudukan, data eksisting pemukiman nelayan berupa sosial budaya, ekonomi, dan lingkungan serta peta dasar wilayah penelitian yang diperoleh dari Bappeda Kota Baubau, BPS Kota Baubau dan dianalisis secara deskriptif kualitatif.Hasil penelitian menunjukkan bahwa kondisi lingkungan permukiman Kelurahan Lakologou Kota Baubau ditinjau dari 1) aspek fisik : prasarana jalan kota sudah memenuhi SPM sedangkan jalan lingkungan dan jalan setapak tidak memenuhi SPM, prasarana drainase di Kelurahan Lakologou sudah memenuhi SPM, prasarana air bersih di Kelurahan Lakologou sudah memenuhi SPM, prasarana MCK di Kelurahan Lakologou sudah memenuhi SPM, prasarana pengolahan air limbah di Kelurahan Lakologou tidak memenuhi SPM, prasarana pengelolaan sampah di Kelurahan Lakologou tidak memenuhi SPM, prasarana jaringan listrik di Kelurahan Lakologou sudah memenuhi SPM, sarana perkantoran dan pemerintahan di Kelurahan Lakologou sudah memenuhi SPM, sarana kesehatan di Kelurahan Lakologou sudah memenuhi SPM, sarana peribadatan di Kelurahan Lakologou sudah memenuhi SPM, sarana perekonomian dan jasa di Kelurahan Lakologou sudah memenuhi SPM; 2) aspek sosial ekonomi : tingkat pendidikan masyarakat relatif rendah yaitu 77,02% berpendidikan dasar (Tidak tamat SD, Tamat SD & SLTP), sebagian besar masyarakat bekerja sebagai petani, nelayan dan pedagang, dan masyarakat memiliki kesadaran yang rendah terhadap kebersihan, kesehatan dan kelestarian lingkungan permukiman. Kata Kunci : Prasarana, Sarana, Permukiman
DINAMIKA PENGGUNAAN LAHAN DI KECAMATAN PUUWATU DAN KECAMATAN BARUGA KOTA KENDARI
Authors: Balaka Sumarni , Geo Laode , Natsir M. 
Published: April 2022

Penelitian ini bertujuan untuk: (1) Mengetahui dan menganalisis dinamika penggunaan lahan di Kecamatan Puuwatu dan Kecamatan Baruga Kota Kendari pada tahun 2008 hingga 2014, (2) Mengetahui dan menganalisis faktor yang mempengaruhi terjadinya perubahan penggunaan lahan di Kecamatan Puuwatu dan Kecamatan Baruga Kota Kendari. Analisis data yang digunakan yaitu Overlay Peta dan analisis regresi berganda. Dinamika Penggunaan Lahan di Kecamatan Puuwatu dan Kecamatan Baruga dari tahun 2008 hingga 2014 mengalami perubahan penggunaan lahan yang sangat dinamis. Penggunaan lahan yang paling besar perubahannya di Kecamatan Puuwatu adalah lahan kebun dan pertanian sedangkan di Kecamatan Baruga adalah lahan terbangun atau permukiman dimana jumlahnya bertambah 502,30 ha. Pertambahan luas lahan terbangun yang signifikan ini merupakan hasil konversi lahan kebun, dan pertanian dimana sawah mengalami penurunan sebesar 137,57 ha, hutan mengalami penurunan sebesar 280,98 ha. dan lahan terbuka mengalami penurunan sebesar 83,75 ha. Faktor yang meningkatkan perubahan penggunaan lahan pertanian menjadi non pertanian di Kecamatan Puuwatu adalah pertumbuhan penduduk, pertumbuhan fasilitas ekonomi dan pertumbuhan fasilitas pendidikan sedangkan di Kecamatan Baruga adalah pertumbuhan fasilitas ekonomi dan pertumbuhan fasilitas pendidikan.Kata kunci: dinamika penggunaan lahan, faktor yang mempengaruhi perubahan penggunaan lahan
FAKTOR EKSTERNAL YANG MEMPENGARUHI PERNIKAHAN DINI PADA WANITA TAHUN 2019
Authors: Koniasari Koniasari 
Published: April 2022

Abstrak.
Pernikahan dini merupakan bagian dari bencana nasional. Pernikahan dini disebabkan oleh berbagai faktor, namun penelitian mengenai faktor eksternal yang mempengaruhi pernikahan dini belum tersedia sehingga penelitian ini perlu dilaksanakan. Metode penelitian yang digunakan metode survey dengan pendekatan cross sectional. Penelitian ini dilaksanakan di Kecamatan Cilamaya Kulon pada bulan November 2019– April 2020. Populasi pada penelitian ini adalah anak yang menikah diusia <19 tahun berjumlah 66 responden dengan kriteria: Wanita usia subur (WUS) yang menikah dan tercatat di KUA Kecamatan Cilamaya Kulon pada tahun 2019, berusia <19 tahun, tinggal di Kecamatan Cilamaya Kulon selama penelitian berlangsung, dapat membaca dan memahami Bahasa Indonesia, sehat jasmani dan rohani, bersedia diwawancara. Instrumen penelitian ini adalah kuesioner, dengan tingkat pengukuran ordinal dan skala Guttman. Didapatkan hasil bahwa faktor yang berpengaruh terhadap pernikahan dini meliputi status bekerja, penghasilan orangtua, media informasi, lingkungan keluarga, dan lingkungan masyarakat dengan faktor yang paling dominan berpengaruh yaitu media informasi. Pengaruh eksternal sangat berperan penting terhadap pola pikir dan pengambilan keputusan bagi keluarga untuk mendorong anak di bawah umur untuk melangsungkan pernikahan dini.
Kata kunci: Faktor eksternal; Pernikahan dini.
Development of a Colloidal Gold Immunochromatographic Strip for Rapid Detection of Cyfra 21-1 in Lymph Node Metastasis of Thyroid Cancer
Authors: Xu Lijie , Wang Shuhao , Wu Zhechen , Xu Chengcheng , Hu Xinwei , Ding Haitian , Zhang Yanqiang , Shen Bing , Liu Yehai , Wu Kaile 
Published: April 2022

Thyroid cancer is the most common endocrine tumor, and the rate of early lymph node metastasis may be as high as 60%. Currently, detection of lymph node metastasis of thyroid cancer during surgery is limited and time-consuming. Elevated levels of Cyfra 21-1, the proteolytic portion of cytokeratin, are associated with the metastasis and progression of thyroid cancer and are an effective biomarker for the prognosis and diagnosis of thyroid cancer. In this study, an immunochromatographic strip test based on colloidal gold nanoparticles was developed to semi-quantitatively detect the levels of Cyfra 21-1 in lymph nodes within 15 min. The standard (calibration) curve equation was Y = 0.003708 × X + 0.1101, and the detection limit was 0.55–1.14 ng mL−1. The strip did not detect other protein markers of epithelial cells at a concentration of 500 ng mL−1, including cytokeratin 8, cytokeratin 18, epithelial membrane antigen, and epidermal surface antigen. The ability of the strip to differentiate positive from negative metastasis in 40 lymph node specimens was 100% concordant with that of immunohistochemical staining for Cyfra 21-1. In an assessment of 20 lymph node specimens that had been determined by postoperative histopathology to be positive for lymph node metastasis and 20 specimens that were negative, the sensitivity and specificity of the strip were 100% and 95%, respectively. The sensitivity of the strip remained stable when stored at room temperature for 6 months. Together, these results indicated that although further testing using a larger sample size will be required, this immunochromatographic strip test may be useful for rapid intraoperative detection of thyroid cancer metastasis to lymph nodes.
Increased Serum Soluble Transferrin Receptor Levels Were Associated With High Prevalence of Cardiovascular Diseases: Insights From the National Health and Nutrition Examination Survey 2017–2018
Authors: Zhu Shiyu , Liu Chang , Zhao Chengchen , Chen Guanzhong , Meng Simin , Hong Ma , Xiang Meixiang , Xie Yao 
Published: April 2022

Background: Iron deficiency is common in cardiovascular diseases (CVD), e.g., heart failure and coronary heart disease. Soluble transferrin receptor (sTfR) is a promising marker representing unmet cellular iron demands. However, whether higher serum sTfR is associated with increased risk of CVDs needs further investigation.Methods: In the present cross-sectional study, we analyzed data of 4,867 adult participants of the National Health and Nutrition Examination Survey (NHANES) 2017–2018. Linear regression models were employed to identify possible correlations between sTfR and other characteristics. The association between sTfR and CVDs was assessed with univariable and multivariable logistics regression models.Results: The prevalence of CVDs was 9.5% among participants, and higher sTfR levels were found in participants with CVDs (p &lt; 0.001). Linear regression models revealed positive associations between sTfR and age, body mass index, systolic blood pressure, glycated hemoglobulin A1c, and insulin resistance (all p &lt; 0.001). In the multivariable logistics regression model, the adjusted odds ratio of sTfR for CVDs was 2.05 (per 1 log2 mg/L, 95% confidence interval: 1.03∼4.05, p = 0.046). Further subgroup analysis identified the associations of sTfR and CVDs were only significant in participants ≥60 years old, or with hypertension (all p &lt; 0.05).Conclusion: Our study demonstrated that increased serum sTfR levels were associated with a high prevalence of cardiovascular diseases.
Understanding the Structure and Energy Transfer Process of Undoped Ultrathin Emitting Nanolayers Within Interface Exciplexes
Authors: Xu Ting , Fu Jianhui , Wang Xinzhong , Lu Guanhua , Liu Baiquan 
Published: April 2022

Organic light-emitting diodes (OLEDs) have great potential for display, lighting, and near-infrared (NIR) applications due to their outstanding advantages such as high efficiency, low power consumption, and flexibility. Recently, it has been found that the ultrathin emitting nanolayer technology plays a key role in OLEDs with simplified structures through the undoped fabricated process, and exciplex-forming hosts can enhance the efficiency and stability of OLEDs. However, the elementary structure and mechanism of the energy transfer process of ultrathin emitting nanolayers within interface exciplexes are still unclear. Therefore, it is imminently needed to explore the origin of ultrathin emitting nanolayers and their energy process within exciplexes. Herein, the mechanism of films growing to set ultrathin emitting nanolayers (&lt;1 nm) and their energy transfer process within interface exciplexes are reviewed and researched. The UEML phosphorescence dye plays a key role in determining the lifetime of excitons between exciplex and non-exciplex interfaces. The exciplex between TCTA and Bphen has longer lifetime decay than the non-exciplex between TCTA and TAPC, facilitating exciton harvesting. The findings will be beneficial not only to the further development of OLEDs but also to other related organic optoelectronic technologies.
A Comparison of XGBoost, Random Forest, and Nomograph for the Prediction of Disease Severity in Patients With COVID-19 Pneumonia: Implications of Cytokine and Immune Cell Profile
Authors: Hong Wandong , Zhou Xiaoying , Jin Shengchun , Lu Yajing , Pan Jingyi , Lin Qingyi , Yang Shaopeng , Xu Tingting , Basharat Zarrin , Zippi Maddalena , Fiorino Sirio , Tsukanov Vladislav , Stock Simon , Grottesi Alfonso , Chen Qin , Pan Jingye 
Published: April 2022

Background and AimsThe aim of this study was to apply machine learning models and a nomogram to differentiate critically ill from non-critically ill COVID-19 pneumonia patients.MethodsClinical symptoms and signs, laboratory parameters, cytokine profile, and immune cellular data of 63 COVID-19 pneumonia patients were retrospectively reviewed. Outcomes were followed up until Mar 12, 2020. A logistic regression function (LR model), Random Forest, and XGBoost models were developed. The performance of these models was measured by area under receiver operating characteristic curve (AUC) analysis.ResultsUnivariate analysis revealed that there was a difference between critically and non-critically ill patients with respect to levels of interleukin-6, interleukin-10, T cells, CD4+ T, and CD8+ T cells. Interleukin-10 with an AUC of 0.86 was most useful predictor of critically ill patients with COVID-19 pneumonia. Ten variables (respiratory rate, neutrophil counts, aspartate transaminase, albumin, serum procalcitonin, D-dimer and B-type natriuretic peptide, CD4+ T cells, interleukin-6 and interleukin-10) were used as candidate predictors for LR model, Random Forest (RF) and XGBoost model application. The coefficients from LR model were utilized to build a nomogram. RF and XGBoost methods suggested that Interleukin-10 and interleukin-6 were the most important variables for severity of illness prediction. The mean AUC for LR, RF, and XGBoost model were 0.91, 0.89, and 0.93 respectively (in two-fold cross-validation). Individualized prediction by XGBoost model was explained by local interpretable model-agnostic explanations (LIME) plot.ConclusionsXGBoost exhibited the highest discriminatory performance for prediction of critically ill patients with COVID-19 pneumonia. It is inferred that the nomogram and visualized interpretation with LIME plot could be useful in the clinical setting. Additionally, interleukin-10 could serve as a useful predictor of critically ill patients with COVID-19 pneumonia.
Global Burden, Incidence and Disability-Adjusted Life-Years for Dermatitis: A Systematic Analysis Combined With Socioeconomic Development Status, 1990–2019
Authors: Xue Yi , Bao Wu , Zhou Jie , Zhao Qing-Liang , Hong Su-Zhuang , Ren Jun , Yang Bai-Cheng , Wang Peng , Yin Bin , Chu Cheng-Chao , Liu Gang , Jia Chi-Yu 
Published: April 2022

BackgroundDermatitis is an important global health problem that not only affects social interaction and physical and mental health but also causes economic burden. Health problems or distress caused by dermatitis may be easily overlooked, and relevant epidemiological data are limited. Therefore, a better understanding of the burden of dermatitis is necessary for developing global intervention strategies.MethodsAll data on dermatitis, including atopic dermatitis (AD), contact dermatitis (CD) and seborrhoeic dermatitis (SD), were obtained from the Global Burden of Disease 2019 (GBD2019) database. The extracted age-standardized incidence rates (ASIR) and disability-adjusted life-years (DALYs) rates (ASDR) data were analysed by stratification, including by sex, country or region, and sociodemographic index (SDI) indicators. Finally, we analysed the correlation between the global burden of dermatitis and socioeconomic development status.ResultsAccording to the GBD 2019 estimate, the ASIR and ASDR for the three major types of dermatitis in 2019 were 5244.3988 (95% CI 4551.7244–5979.3176) per 100,000 person-years and 131.6711 (95% CI 77.5876–206.8796) per 100,000 person-years. The ASIR and ASDR of atopic dermatitis, contact dermatitis and seborrhoeic dermatitis are: Incidence (95%CI,per 100,000 person-years), 327.91 (312.76-343.67), 3066.04 (2405.38-3755.38), 1850.44 (1706.25- 1993.74); DALYs (95%CI, per 100,000 person-years), 99.69 (53.09-167.43), 28.06 (17.62-41.78), 3.93 (2.24-6.25). In addition, among the three dermatitis types, the greatest burden was associated with AD. According to the ASDR from 1990 to 2019, the burden of dermatitis has exhibited a slow downward trend in recent years. In 2019, the ASIR showed that the USA had the greatest burden, while the ASDR showed that Asian countries (such as Japan, Mongolia, Kazakhstan, and Uzbekistan) and some European countries (France, Estonia) had the greatest burden. According to SDI stratification and the three major dermatitis types, high ASIR and ASDR corresponded to high SDI areas (especially for AD).ConclusionThe burden of dermatitis is related to socioeconomic development status, especially for AD, which is positively correlated with the SDI. The results based on GBD2019 data are valuable for formulating policy, preventing and treating dermatitis and reducing the global burden of dermatitis.
Burden of Peripheral Artery Disease and Its Attributable Risk Factors in 204 Countries and Territories From 1990 to 2019
Authors: Lin Jinfeng , Chen Yangbo , Jiang Nan , Li Zuoshi , Xu Shangbo 
Published: April 2022

BackgroundData on burden of peripheral artery disease (PAD) and its attributable risk factors are valuable for policymaking. We aimed to estimate the burden and risk factors for PAD from 1990 to 2019.MethodsWe extracted the data on prevalence, incidence, death, years lived with disability (YLDs), and years of life lost (YLLs) from the Global Burden of Disease Study 2019 to measure PAD burden. Moreover, the attributable burden to PAD risk factors was also estimated.ResultsGlobally, in 2019, 113,443,017 people lived with PAD and 10,504,092 new cases occurred, resulting in 74,063 deaths, 500,893 YLDs, and 1,035,487 YLLs. The absolute numbers of PAD prevalent and incident cases significantly increased between 1990 and 2019, contrasting with the decline trends in age-standardized prevalence and incidence rates. However, no statistically significant changes were detected in the global age-standardized death or YLL rates. The burden of PAD and its temporal trends varied significantly by location, gender, age group, and social-demographic status. Among all potentially modifiable risk factors, age-standardized PAD deaths worldwide were primarily attributable to high fasting plasma glucose, followed by high systolic blood pressure, tobacco, kidney dysfunction, diet high in sodium, and lead exposure.ConclusionPAD remained a serious public health problem worldwide. More strategies aimed at implementing cost-effective interventions and addressing modifiable risk factors should be carried out, especially in regions with high or increasing burden.
Rhyolitic Ash Promoting Organic Matter Enrichment in a Shallow Carbonate Platform: A Case Study of the Maokou Formation in Eastern Sichuan Basin
Authors: Meng Qingqiang , Pang Qian , Hu Guang , Jin Zhijun , Zhu Donhya , Liu Jiayi , Zhang Chuanwen 
Published: April 2022

Volcanic ash improves the amount of nutritive elements in the lake and ocean, but it is not fully understood how volcanic ash influences the total organic matter content (TOC) and bio-precursor, and the scope. A volcanic layer, measuring 5 cm in thickness, was examined using electron microscopy scanning, TOC/TS, rock pyrolytic, and inorganic geochemical analyses. The study shows that the TOC content in the overlying shales increases by 18 wt.% on average, and the vertical scope of influence on shales is twice as thick as the volcanic layer. Organic matter enrichment is attributed to the fact that the volcanic layer provides nutritive elements and meanwhile changes the oxidation-reduction condition. Large variations of hydrogen index (HI) and oxygen index (OI) in the lower and upper parts of the volcanic layer is related to terrestrial organic matter vanishing, due to volcanic eruption and subsequently more terrigenous organic matter migrating into the ocean. Little change of the bio-precursor in the overlying and underlying shales may be related to the fast restoration within the ocean and land ecosystems after a volcanic eruption. The decrease in terrigenous sediments indicated by Rb/Sr, Zr/Y, and ∑REE after a volcanic eruption indirectly reflects fast restoration of terrestrial vegetation boom. This study could decipher the influence of volcanic ash on the qualities of the source rock, which can provide a better understanding on discovering more economically petroleum reservoirs in igneous rocks.
Association Between Maternal Characteristics and the Risk of Isolated Maternal Hypothyroxinemia
Authors: Liu Yang , Li Guohua , Guo Nafei , Liu Xiaosong , Huang Shijia , Du Qiaoling 
Published: April 2022

ObjectiveWe aimed to determine the association between maternal characteristics and isolated maternal hypothyroxinemia (IMH).MethodsPregnancies registered at Shanghai First Maternity and Infant Hospital between January 2014 and September 2020 were included in this cross-sectional study. IMH was defined as free thyroxine (FT4) levels below the 10th percentile with TSH within the normal reference range. Multivariate logistic regression models were used to identify potential risk factors for IMH, including demographic information, anthropometric measurements and nutritional status.ResultsA total of 54586 singleton pregnancies were included, involving 6084 women with IMH and 48502 euthyroid women. Multivariate logistic regression analyses showed that the variables for women with ages ≥35 (adjusted OR = 1.30, 95% CI:1.20–1.40), non-local residence (adjusted OR = 1.16, 95% CI:1.09–1.23), multiparas (adjusted OR = 1.11, 95% CI:1.03–1.21), pre-pregnancy overweight (adjusted OR = 1.37, 95% CI:1.27–1.49) or obesity (adjusted OR = 1.35, 95% CI:1.18–1.54), and iron deficiency (adjusted OR = 1.27, 95% CI:1.20–1.35) were independent risk factors for IMH in the overall study population, which were identical to those in the first trimester subgroup.ConclusionsMaternal characteristics were associated with the onset of IMH. Maternal age, residence of origin, parity, pre-pregnancy body mass index (BMI) and iron status should be comprehensively considered to evaluate the risk of IMH, according to which obstetricians could determine an optimal assessment time for thyroid function.
Comparative Analysis of the Chalcone-Flavanone Isomerase Genes in Six Citrus Species and Their Expression Analysis in Sweet Orange (Citrus sinensis)
Authors: Wan Quan , Bai Tingting , Liu Minmin , Liu Ying , Xie Yating , Zhang Tao , Huang Min , Zhang Jinlian 
Published: April 2022

Citrus fruit contains rich nutrients which is edible and of officinal value. Citrus flavanones are widely used in the treatment of cardiovascular and other diseases, and they are a foundational material of Chinese medicine. The chalcone-flavanone isomerase (CHI) plays a key role in flavanone synthesis. Therefore, we comprehensively analyzed CHI genes in Citrus species. Here, thirty CHI genes were identified for the first time in six Citrus species, which were divided into CHI and FAP groups. Evolutionary analysis showed that CHI gene members were highly conserved and were an ancient family. All CsCHI genes showed the highest expression level after the second physiological fruit-falling period in C. sinensis. CsCHI1 and CsCHI3 were highly expressed at 50 days after the flowering (DAF) stage in albedo. The expression of CsFAP2 and CsCHI3 genes at the 50 DAF stage was 16.5 and 24.3 times higher than that at the 220 DAF stage, respectively. The expression of CsCHI1, CsCHI3, and CsFAP2 genes in the peel was higher than that in the pulp, especially in common sweet orange. The CsCHI3 gene maintained a high expression level in the epicarp and juice sac at all periods. The members of CHIs interacted with chalcone synthase (CHS), flavonol synthase/flavanone 3-hydroxylase (FLS) and naringenin, and 2-oxoglutarate 3-dioxygenase (F3H) to form heterodimers, which might together play a regulatory role and participate in the flavonoid pathway. This study will provide the basis for the selection of flavonoids in plant tissues and periods and fundamental information for further functional studies.