bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics, Effect of Histological Grade and Localization on the Prognosis of Colorectal Cancer. A retrospective Study.
Authors: Çuedari Enkelejda , Ikonomi Majlinda , Pema (Kristo) Anila , Tarifa Dhurata 
Published: July 2022

Background: Colorectal cancer is the third most deadly cancer and the fourth most frequent in the world according to GLOBOCAN 2018. The number of new cases is growing up, which may also be related to lifestyle. Many studies have shown a difference in the number of males and females, correlation of localization, stage, and grade with prognosis.
Material and Methods: In our study were included operated cases with colorectal cancer in University Hospital Center “Mother Theresa” during the period from January 1, 2016, to December 31, 2017.
In our study, the total number of patients enrolled is 334. In the end was evaluated the correlation between histological grade, stage, and localization with prognosis.
Results: From the study resulted that males were affected more than females by colorectal cancer.
The average age of diagnosis of colorectal cancer is 63.9 (±12.4) years. Moderately differentiated adenocarcinoma, histological grade II and pathological stage pT3N0Mx after TNM are predominant.
The commonest localization is the rectum. Disease-free survival is better in stages I and IIa than in other stages, least favorable in poorly differentiated adenocarcinoma.
Conclusion: In Albania, patients diagnosed with CRC showed a low survival rate specific to cancer.
The type of histology, the stage of cancer, the level of CEA at diagnosis, and the type of treatment a patient received significantly determine the mortality rate.
Therefore, cancer screening programs can help to detect the disease at an early stage and initiate timely available treatments in order to extend the life expectancy of CRC patients.
Perioperative Management in a Patient with WPW Syndrome undergoing Plastic Surgery.
Authors: Zeka Merita , Goga Marsela , Kuci Saimir , Ibrahimi Alfred , Bejko Ervin , Lilaj Krenar 
Published: July 2022

Perioperative management of patients with preexcitation may become quite challenging, especially if there is no time for adequate preoperative investigation and clinical optimisation, as in emergencies, or even worse, in undiagnosed cases. It is possible that the poorly controlled or unknown underlying electrophysiological abnormality will become unmasked during anaesthesia and surgery, giving rise to potentially life-threatening arrhythmias.
In the literature, pre-excitation syndromes have been mainly approached from the view of the disease (i.e., presentation, diagnosis, treatment), while anaesthetic data are scarce.
This case report aims to focus on the perioperative management of patients with WPW.
Conclusion; Managing such cases provides an opportunity to revisit important considerations on Wolff-Parkinson-White syndrome Avoiding neuromuscular blockers may make a difference in avoiding arrhythmias when laryngeal mask airway / general anaesthesia is required in patients with Wolff-Parkinson-White syndrome. Sympathetic stimulation should be avoided as it may shorten the refractory period of AP and alleviate life-threatening arrhythmias.
Pengaruh Persepsi Kemudahan Dan Persepsi Fitur Layanan Islami Terhadap Keputusan Nasabah Menggunakan Mobile Banking Bank Syariah Indonesia Cabang Jember
Authors: Aini Salsabillah Ainun , Wijayantini Bayu , Rusdiyanto Rusdiyanto 
Published: July 2022

Abstrak: Tujuan penelitian ini adalah untuk menguji dan menganalisis pengaruh persepsi kemudahan dan persepsi fitur layanan islami terhadap keputusan nasabah menggunakan mobile banking Bank Syariah Indonesia cabang Jember. Jenis penelitian yag digunakan merupakan kuantitatif. Alat analisis dengan mengunakan teknis analisis Regresi Linear Berganda, Uji Hipotesis, dan Koefisien Determinasi. Data yang digunakan dalam penelitian ini adalah data primer dan sekunder. Hasil penelitian menunjukkan persepsi kemudahan berpengaruh positif dan signifikan terhadap keputusan nasabah menggunakan mobile banking Bank Syariah Indonesia cabang Jember, dan persepsi fitur layanan islami berpengaruh positif dan signifikan terhadap keputusan nasabah menggunakan mobile banking Bank Syariah Indonesia cabang Jember.
Poor Prognosis of Diffuse Large B-Cell Lymphoma of the Breast: The Role of Dose-Dense Chemotherapy
Authors: Aviles Agustin , Silva Luis , Cleto Sergio 
Published: July 2022

Background: The aim of the study was to define if the use of an intensive regimen (dose-dense) of chemotherapy may improve response rate and outcome in patients with primary breast lymphoma (PBL), whose is considered as lymphoma presentation with an worse prognosis.
Methods: Patients with pathological confirmed diagnosis of diffuse large B-cell lymphoma with clinical presentation on breast (PBL) , > 18 years old, stage I and II, negative for immunodeficient syndrome, hepatitis A and B, previously untreated , with non-germinal center cell, were included in a open label clinical trial, phase II, were allocated to received an dose dense regimen of CHOP (cyclophosphamide , doxorubicine, vincristine and prednisone)
Results: Between July 2006 to December 2016, seventy eight patients were enrolled in the study. Complete response was achieved in 76 (94.4%), patients. Five patients relapse , thus progression free survival at 5 years was 94.0% (95 % Confidence interval (CI): 87% to 98%%): three patients achieved a second response and are alive, overall survival at 5-years was : 95.3 (96%CI: 89% to 102%).Relapse at central nervous system has not been observed. Severe granulocytopenia was observed in 42.8 (93.0%) cycles, but no death associated to treatment were observed.
Conclusion: The use a dose-dense regimen of chemotherapy improve outcome in this setting of patients; although severe acute toxicities were frequent , it well controlled. Relapse in central nervous system has not been observed. Thus, we considered that dose-dense chemotherapy will be employed in this setting of patients.
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 5 No. 2 May 2022
Authors: Borneo J Pharm Chief Editor Of 
Published: July 2022

Assalamu’alaikum Wr. Wb.
Alhamdulillahirabbil ‘alamin. The next edition of the Borneo Journal of Pharmacy (Borneo J Pharm) has been published in May 2022. This edition contains ten articles consisting of Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Microbiology Pharmacy, Natural Product Development, and Clinical-Community Pharmacy. This edition includes writings from four countries, including India, Indonesia, Nigeria, and Sri Lanka. The authors come from several institutions, including Universitas Pancasila, University of Jaffna, Universitas Muhammadiyah Prof. Dr. HAMKA, Universitas Setia Budi, Federal University Birnin Kebbi, Kano State Polytechnic, Universitas Muhammadiyah Palangkaraya, Prathima Institute of Medical Sciences, Bhaskar Pharmacy College, Ganapathy Degree College, Universitas Muhammadiyah Malang, Universitas Muhammadiyah Magelang, and Universitas Andalas.
Editorial boards are fully aware that there is still room for improvement in this edition, hence with all humility, willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank all editors and reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope that all parties, especially the contributors, could re-participate for publication in the next edition in August 2022.
Wassalamu’alaikum Wr. Wb.
Biopesticides: a sustainable approach for pest management
Authors: Parajuli Sovit , Shrestha Jiban , Subedi Sudeep , Pandey Meena 
Published: July 2022

Biopesticides are an important component of Integrated Pest Management (IPM) programs for insect pest control since they are more natural, environmentally friendly, safer than chemical pesticides and have relatively no or little effect on non-target organisms. They aid in improving crop health and yields while lowering production costs and eliminating the usage of toxic chemicals. They are effective tools for creating new sustainable agricultural products. Several botanicals and microbial biopesticides have been identified, isolated, processed, and used to eliminate hazards caused by Coleopteran, Hemipteran, Dipteran, Lepidopteran, Hymenopteran, and Thysanopteran insects. Several species of botanicals such as Neem (Azadirachta indica A.), Chili pepper (Capsicum annuum), Garlic (Allium sativum), Moringa (Moringa oleifera), Clove basil (Ocimum gratissimum), China berry (Melia azedarach), bitter leaf (Vernonia amygdalina) etc. and microbes such as Bacillus thuringiensis, Beauveria bassiana, Metarhizium anisopliae, Baculovirus (nucleopolyhedrovirus (NPV) and granulovirus (GV) ), Steinernema carpocapsae, Nosema, etc. have been used as biopesticides. Because biopesticides are successful in managing insect pests and diseases while also being safe to humans and the environment, they must be manufactured in the country and made available to farmers.
SAARC J. Agric., 20(1): 1-13 (2022)
Field evaluation of promising mutants of mungbean against Fela Beetle, Aphid and POD Borer
Authors: Islam MM , Khan Md Mohasin Hussain , Asaduzzaman Md 
Published: July 2022

Experiment was conducted at the Agricultural Farm of Patuakhali Science and Technology University to know the morphological characteristics of different mutants of mungbean and to find out tolerant/least susceptible mutant(s) against flea beetle, aphid and pod borer based on the reaction of insect pests to promising mutants of mungbean during the period from April to June, 2015. The mutant MBM-07(S)-2 was found to be the tallest (32.57 cm) with highest number of branches/plant (5.03), highest number of leaves/plant (11.06) among all mutants and check variety while MBM-07-Y-2 (23.40 cm) was the shortest plant height, MBM-656-51-2 had the lowest number of branches/plant (3.73), MBM-347-13 (7.03) had the lowest number of leaves/plant. The mutant MBM-427-87-3 had the highest number of pods (5.00) compared to other mutants but MBM-656-51-2 had the lowest number of pods/plant (3.09). Significantly the highest pod length and the highest number of seeds/pod were recorded in the mutant MBM-07-Y-1 (6.37 cm) while the lowest pod length (5.19 cm) was in MBM-80(LCAL) and lowest number of seeds/pod was in the mutant MBM-390-94-Y (5.34). Mutant MBM-347-13 had the lowest population of flea beetle (18.00) and pod borer (2.00) compared to all other mutants while the lowest number of aphid/plant was observed in mutant MBM-07-Y-1 (1.00). In case of infestation, the mutant MBM-347-13 had the lowest percentage of infestation (20.69%) by flea beetle, (3.18%) by pod borer but the lowest infestation by aphid (3.33%) was recorded in the mutant MBM-390-94-Y while the mutant MBM-427-87-3 had the highest percentage of plant infestation (37.80%) by flea beetle, pod damage (9.69%) by pod borer and variety BARI moog-6 had the highest percentage (34.45%) of plant infestation by aphid. Mutant MBM-347-13 was least susceptible to flea beetle and pod borer while mutant MBM-427-87-3 was highly susceptible to flea beetle and pod borer. However, mutant MBM-390-94-Yand MBM-07-Y-2 were less susceptible to aphid while BARI moog-6 and mutant MBM-427-87-3 were highly susceptible to aphid.
SAARC J. Agric., 20(1): 97-106 (2022)
Effect of different concentrations of pyrethroid and organophosphorus pesticides on seedling growth of Cicer arietinum
Authors: Dixit Renu , Rani Manju , Kumar Jitendra 
Published: July 2022

Seed treatment with pesticides is one of the components of IPM. Pesticides, the chemical ingredients are generally used to assassinate biological entities that cause damage to cultivated crops. To maintain the quantity and quality of the plant produce, a large number of chemicals in the form of pesticides and/or fungicides are sprayed on them. Although these compounds affect the growth of seedlings and also negatively influence the growth of symbiotic bacteria and their interaction with crop plants resulting in a reduction in nitrogen fixation by plants and ultimately yield. A study on the consequences of chemical pesticides on seed germination and seedling growth of Cicer arietinum was carried out at Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, India in 2016. The present study was done to assess the effect of pesticides on root length, shoot length, leaf area, fresh weight, and dry weight of seedlings. The experiment was conducted by using different concentrations viz., 0% (control), 0.5%, 1%, 1.5%, 2%, 2.5%, 5%, 7.5%, and 10% of organophosphorus monocrotophos and pyrethroid pesticide deltamethrin. Observations were done on the 7th, 14th, and 21st days of radicle emergence. The study showed that both types of pesticides such as pyrethroid deltamethrin and organophosphorus monocrotophos were found to be toxic to plants in high concentrations and can be preferred in low concentrations only like 0.5%, which is less harmful to crop plants.
SAARC J. Agric., 20(1): 55-65 (2022)
Producción de pimiento (Capsicum annuum) en invernadero: comparación entre tipos de pimiento
Authors: Monge-Pérez José Eladio , Elizondo-Cabalceta Esteban , Loría-Coto Michelle 
Published: July 2022

Se realizó una comparación agronómica entre tres tipos de pimiento (cónico, cuadrado, y rectangular), producidos bajo invernadero, a nivel cuantitativo (12 variables), en Alajuela, Costa Rica. El cultivo se manejó con fertirrigación, en sustrato de fibra de coco. En comparación con los otros tipos de pimiento evaluados, el pimiento cónico presentó el menor peso del fruto, ancho del fruto y espesor del pericarpio, y la mayor relación longitud/ancho del fruto y cantidad de frutos totales por planta. Además, el pimiento cuadrado presentó la menor altura de planta, área de la hoja, longitud del fruto y relación longitud/ancho del fruto, y el mayor ancho del fruto y espesor del pericarpio. No se presentaron diferencias significativas en el diámetro del tallo, la edad a inicio de la cosecha, el número de frutos de primera calidad por planta, ni el rendimiento total ni comercial, entre los diferentes tipos de pimiento. La opción más rentable para los agricultores en Costa Rica parece ser el cultivo de pimiento cuadrado, debido a que sus frutos tienen un precio que duplican el del pimiento cónico, aunque el tamaño del mercado es menor.
Analysis of recurrent urinary tract infection (UTI) in University Hospital – approach of antibiotic resistance in clinical isolates
Authors: Alves Danilo Antonini , Guarnieri João Paulo de Oliveira , Bernardes Bruno Gaia , Silva Carlos Fernando Macedo da , Lancellotti Marcelo 
Published: July 2022

The fifty-two bacteria were isolated from urinary tract infections in University Hospital in Sumaré, São Paulo State, Brazil. These isolates were analyzed about their antibiotic resistance and their bacterial characteristics. Around percentage from these isolates were identified as belonging to Escherichia coli strains, followed by Klebsiella pneumoniae and Pseudomonas aeruginosa. The multiresistance profile (resistance profile major than four 4 antibiotic classes) were viewed in thirteen (13) strains of Escherichia coli, sixteen (16) strains in Klebsiella pneumoniae (being two (2) carbapenem resistant suggesting an existence of KPC strain). The results had demonstrated an indiscriminate antibiotic use concentrated in the increase of quinolones resistance (principally in ciprofloxacin use), and also the rise of KPC super bacteria.
Associação patológica e histórica entre a Síndrome de Guillain-Barré (SGB) e infecção pelo Zika Vírus
Authors: Silva João Felipe Tinto , Medeiros Felipe Lima de , Mello Emmanuella Costa de Azevedo , Sousa Emanuel Osvaldo de , Oliveira Ingrid Mikaela Moreira de , Araújo Emanueli Larice Costa , Soares Gustavo Henrique dos Santos , Lima Tuanny Beatriz dos Santos , Souza Thaís Ferreira Modesto , Leal Elayne Cristina Pereira de Souza , Leitão Darlly Tavares , Andrade Katia Helena Marinho de 
Published: July 2022

Introdução: A origem da SGB ainda é desconhecida, contudo, frequentemente é precedida por uma infecção, havendo relatos da sua relação com a infecção pelo Zika Vírus. Objetivo: investigar a relação existente entre a infecção pelo Zika vírus e a Síndrome de Guillain-Barré (SGB). Método: Revisão integrativa da literatura realizada através de bases de dados indexadas na Biblioteca Virtual em Saúde (BVS), utilizando os descritores: “Infecção por Zika Vírus”, “Infecções por Arbovirus” e “Síndrome de Guillain-Barré”. Foram selecionados 06 estudos. Resultados: Os mecanismos fisiopatológicos subjacentes da SGB ligados ao vírus de Zika são desconhecidos, embora as reações imunológicas descritas com outros micróbios patogênicos poderiam ter o mesmo papel putativo. Além disso, não há nenhuma explicação válida para a emergência desta complicação que não foi relacionada previamente ao Zika vírus. Uma teoria é que o vírus evoluiu geneticamente a um genótipo mais patogênico. Considerações Finais: É relata uma associação entre a SGB e a infecção pelo Zika vírus, existindo algumas hipóteses e estudos realizados que visam investigar a fisiopatologia envolvida nessa associação. Apesar dos estudos recentes, são necessários mais estudos para aprofundar o entendimento completo dos mecanismos envolvidos.
Association of Serum Bilirubin With Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Authors: Liang Chen , Yu Zhiyuan , Bai Li , Hou Wei , Tang Shan , Zhang Wei , Chen Xinyue , Hu Zhongjie , Duan Zhongping , Zheng Sujun 
Published: July 2022

ObjectiveMetabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD) are the leading chronic diseases worldwide. There are still many controversies about the association between serum bilirubin and MetS or NAFLD. This study aims to evaluate the association of serum total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL) with MetS and NAFLD.MethodsMultiple databases were searched for relevant studies until November 2021. Randomized controlled trials, cross-sectional and cohort studies evaluating the association between serum bilirubin levels and MetS or NAFLD were included.ResultsTwenty-four cross-sectional and cohort studies with 101, 517 participants were finally analyzed. Fifteen studies and 6 studies evaluated the association between bilirubin and MetS or NAFLD in health screening population, respectively, while 3 studies evaluated the association between bilirubin and non-alcoholic steatohepatitis (NASH) in NAFLD patients. Random effect model analysis showed the inverse association between TBIL and MetS in male (95%CI=0.71-0.96) and gender-neutral (95%CI=0.61-0.91) group. However, no significant association was found in females. Notably, the inverse association between DBIL and MetS was noticed in male (95%CI=0.36-0.75), female (95%CI=0.16-0.58) and gender-neutral population (95%CI=0.67-0.92). IBIL level was inversely associated with MetS in females (95%CI=0.52-0.96), whereas no statistical correlation presented in males. TBIL was not statistically correlated with NAFLD in gender-neutral or male subgroup. Similarly, there were no association between DBIL or IBIL and NAFLD in gender-neutral subgroup. However, the negative correlation between DBIL and NAFLD existed in males (95%CI=0.76-0.96). In NAFLD patients, IBIL analysis showed an inverse association with NASH (95%CI=0.01-0.12).ConclusionSerum TBIL and DBIL levels, especially DBIL levels, assume an inverse correlation with MetS in healthy population. Serum IBIL is inversely associated with the onset and degree of NASH in NAFLD patients. Exogenous bilirubin supplement may be a potential strategy to assist in lowering the risk of developing MetS and NAFLD.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021293349
Modelling the Dispersion of Seafloor Massive Sulphide Mining Plumes in the Mid Atlantic Ridge Around the Azores
Authors: Morato Telmo , Juliano Manuela , Pham Christopher K. , Carreiro-Silva Marina , Martins Inês , Colaço Ana 
Published: July 2022

It is increasingly recognised that deep-sea mining of seafloor massive sulphides (SMS) could become an important source of mineral resources. These operations will remove the targeted substrate and produce potentially toxic plumes from in situ seabed excavation and from the return water pumped back down to the seafloor. However, the spatial extent of the impact of deep-sea mining is still uncertain because few field experiments and models of plume dispersion have been conducted. In this study, we used three-dimensional hydrodynamic models of the Azores region together with a theoretical commercial mining operation of polymetallic SMS to simulate the potential dispersal of plumes originating from different phases of mining operations, and to assess the magnitude of potential impacts. Although the model simulations presented here were subject to many caveats, they did reveal some important patterns. The model projected marked differences among sites making generalisations about plume-dispersal patterns in mid-ocean ridges difficult. Nevertheless, the models predicted large horizontal and vertical plume-dispersals above the thresholds adopted. Persistent plumes (temporal frequency &gt;50%, i.e., 6 months out of 12 months) were projected to disperse an average linear distance of 10 to 20 km, cover an area of 17 to 150 km2, and extend more than 800 m in the water column. In fact, the model projected that plumes may disperse beyond the licensed mining areas, reach the flanks and summits of nearby topographic features, and extend into the bathypelagic, mesopelagic, and epipelagic environments. Modelled plume-dispersal overlaps with the predicted distribution of cold-water corals and with existing fishing activities. These potential impacts would be of particular concern in regions such as the Azores, where local populations are highly dependent on the sea for their livelihoods. The findings of this study are an important initial step towards understanding the nature and magnitude of deep-sea mining impacts in space and time.
Electrical Impedance Analysis for Lung Cancer: A Prospective, Multicenter, Blind Validation Study
Authors: Yang Dawei , Gu Chuanjia , Gu Ye , Zhang Xiaodong , Ge Di , Zhang Yong , Wang Ningfang , Zheng Xiaoxuan , Wang Hao , Yang Li , Chen Saihua , Xie Pengfei , Chen Deng , Yu Jinming , Sun Jiayuan , Bai Chunxue 
Published: July 2022

HypothesisPatients with cancer have different impedances or conductances than patients with benign normal tissue; thus, we can apply electrical impedance analysis (EIA) to identify patients with cancer.MethodTo evaluate EIA’s efficacy and safety profile in diagnosing pulmonary lesions, we conducted a prospective, multicenter study among patients with pulmonary lesions recruited from 4 clinical centers (Zhongshan Hospital Ethics Committee, Approval No. 2015-16R and 2017-035(3). They underwent EIA to obtain an Algorithm Composite Score or ‘Prolung Index,’ PI. The classification threshold of 29 was first tested in an analytical validation set of 144 patients and independently validated in a clinical validation set of 418 patients. The subject’s final diagnosis depended on histology and a 2-year follow-up.ResultsIn total, 418 patients completed the entire protocol for clinical validation, with 186 true positives, 145 true negatives, 52 false positives, and 35 false negatives. The sensitivity, specificity, and diagnostic yield were 84% (95% CI 79.3%-89.0%), 74% (95% CI 67.4%-79.8%), and 79% (95%CI 75.3%-83.1%), respectively, and did not differ according to age, sex, smoking history, body mass index, or lesion types. The sensitivity of small lesions was comparable to that of large lesions (p = 0.13). Four hundred eighty-four patients who underwent the analysis received a safety evaluation. No adverse events were considered to be related to the test.ConclusionElectrical impedance analysis is a safe and efficient tool for risk stratification of pulmonary lesions, especially for patients with a suspicious lung lesion.