bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oil and gas perspectives of the Ordoviksky-Nizhnefransky mega-complex of the Pechorsk Sea shelf
Authors: Dzyublo A. D. , Sidorov V. V. , Zonn M. S. , Agadzhanyants I. G. 
Published: January 2022

A fundamentally important result of offshore exploration is the identification of a new oilbearing region in the eastern part of the Pechomorsk shelf. Large oil fields have been discovered here: Prirazlomnoye, Varandey-more, Medynskoye-more, Dolginskoye. The explored reserves and resources of hydrocarbons (HC) suggest that in the near future a new oil-producing region will be formed on the shelf of the Pechora Sea. According to the State Balance, the total initial raw oil resources in the Pechora Sea are 3273.2 million tons. The main task of our work is the desire of the authors to draw attention to the problem of accelerating the pace of searches for promising objects on the shelf of the Pechora Sea and additional exploration of already discovered deposits in the Ordovician-Lower Fransk oil and gas megacomplex in the Varandey-Adzvinskaya structural zone (VASZ).The prevailing disproportion between the plans for the development of the fuel and energy complex, its resource availability and the rate of replenishment of the hydrocarbon raw material base of the Pechora Sea shelf may turn into serious problems for the energy security of the country.The further development of a large oil production cluster on the shelf of the Pechora Sea is primarily associated with the prospecting and development of hydrocarbon resources of the relatively deep-lying oil and gas bearing predominantly carbonate Ordovician-Lower Fransky megacomplex (MC) on the VASZ shelf and adjacent areas, especially at the Prirazlomnoye and Medynskoye-more fields.
Neopleistocene aqifer sistem in the astrakhan gas condensate field: specifics, structure and models of formation
Authors: Golovanova O. G. , Pitjeva K. E. 
Published: January 2022

The paper presents an analysis of materials from studies of the Neopleistocene sedimentary complexes and aquifer system: lithological, mineralogical-geochemical, hydrogeochemical, hydrogeofiltration and hydrogeomigration in the region of development of the Astrakhan gas condensate field (AGCF). The main provisions of the model of the formation of groundwater, the specifics of their balance, the chemical composition of hydrogeodynamics, hydrogeomigration, and the main governing factors are formulated. The predominance of marine sediments in complexly constructed strata of the Neopleistocene, with a significant role of clay layers and fragmentary traces of continental development, was revealed. Facies and sedimentary environments characteristic of large deltas and shallow marine areas, like the modern North Caspian, have been identified. The system of deltas and deltas of large and small streams is considered with the involvement of geomorphological, landscape-climatic and geodynamic factors for the development of a model for the formation of the studied strata.In the upper part of the litho-hydrosphere of the AGKM region, a specific landscape-geomorphological pattern was revealed, reflecting the systems of zones of geodynamic instability on a scale of the first hundreds of meters-kilometers. In a significant part of the study area, an association of areas of the greatest thickness and conductivity of aquifers of the Neopleistocene complex with interdome depressions of deep halogenetic structures was revealed. The results obtained are relevant for the development of a model for the formation of aquatic-rock complexes of the Neopleistocene and management of the development of AGCF: identifying ways of spreading pollution; reducing the risk of accidents due to the instability of the foundations of the gas complex facilities and many others.
Online Learning for Foot Contact Detection of Legged Robot Based on Data Stream Clustering
Authors: Liu Qingyu , Yuan Bing , Wang Yang 
Published: February 2022

Foot contact detection is critical for legged robot running control using state machine, in which the controller uses different control modules in the leg flight phase and landing phase. This paper presents an online learning framework to improve the rapidity of foot contact detection in legged robot running. In this framework, the Gaussian mixture model with three sub-components is adopted to learn the contact data vectors corresponding to running on flat ground, running upstairs, and running downstairs. An online data stream learning algorithm is used to update the model. To deal with the difficulty in obtaining contact data at landing moment online, a “trace back” module is designed to trace back the contact data in the memory stack until the data meet with the probability contact criterion. To test if the foot is in contact with the ground, a projection method is proposed. The acquiring data vector during the leg flight phase is projected onto an independent random vector space, and the contact event is triggered if all projected random variables fall within 1.5σ of the corresponding Gaussian distribution. Experiments on a legged robot show that the presented algorithm can predict the foot contact 16 ms in advance compared with the prediction using only leg force, which will ease the controller design and enhance the stability of legged robot control.
Cytokinesis During the First Division of a Mouse Embryo
Authors: Fan Xiao-Yan , Wang Xing-Hua , Xie Feng-Yun , Ma Jun-Yu , Ou Xiang-Hong , Luo Shi-Ming 
Published: February 2022

Cell division consists of nuclear division (mitosis for somatic cells and meiosis for germ cells) and cytoplasmic division (cytokinesis). Embryonic developments are highly programmed, and thus, each cellular event during early embryo development is stable. For mouse embryos, the first time of mitosis is completed about 22 h after fertilization. However, it remains unclear when the embryo completes its first cytokinesis. Here, we microinjected only one cell in the 2-cell stage mouse embryos with mRNA, which encodes green fluorescence protein (GFP). By monitoring the GFP protein transport dynamics between the two cells, we demonstrated that the first time of cytokinesis in mouse embryos is completed about 15 h after mitosis, namely 37 h after fertilization. In addition, our results indicate that the cytoplasmic protein transport between daughter cells is very effective, which relies on microtubules instead of microfilaments in 2-cell mouse embryos. These results should enrich people’s understanding of the first cell division and cytoskeleton in mouse embryos and then learn more about the mechanisms of early embryo development in mammals.
Impact of Diabetes Mellitus on Lower Urinary Tract Symptoms in Benign Prostatic Hyperplasia Patients: A Meta-Analysis
Authors: Xin Caihong , Fan Huaying , Xie Jing , Hu Jingcheng , Sun Xin , Liu Qiuchen 
Published: February 2022

BackgroundBenign prostatic hyperplasia (BPH) is a disease that causes lower urinary tract symptoms (LUTS), which are the most common urological problem in approximately one-third of the male population aged over 50 years. Some studies have suggested that diabetes may be a risk factor for the development of BPH. However, whether diabetes aggravates the LUTS of BPH patients is still controversial.AimTo investigate the impact of diabetes mellitus on LUTS in BPH patients.MethodsA literature search was conducted using Web of Science, Embase, PubMed, and China National Knowledge Infrastructure literature databases. This meta-analysis was registered in PROSPERO (registration number: CRD 42020200794). Fixed- or random-effects models were used for analysis according to heterogeneity. The results of the systematic analysis are presented as weighted mean difference (WMD) with the corresponding 95% confidence intervals (CI).ResultsIn total, 1308 studies were retrieved from databases and 18 articles comprising 1685 cases and 4653 controls were selected for meta-analysis. The results of the meta-analysis showed that the International Prostate Symptom Score (IPSS) value and prostate volume of BPH patients with diabetes was significantly higher than that of BPH patients without diabetes.ConclusionsThis systematic review is the first to evaluate the impact of diabetes mellitus on LUTS in BPH patients. The results of our meta-analysis support the hypothesis that LUTS in BPH patients is increased in patients with diabetes mellitus compared with controls, which suggests that physicians should pay more attention to BPH patients with diabetes mellitus.Systematic Review RegistrationPROSPERO [https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=200794], identifier CRD 42020200794.
Effect of Genetic Variants of Gonadotropins and Their Receptors on Ovarian Stimulation Outcomes: A Delphi Consensus
Authors: Conforti Alessandro , Tüttelmann Frank , Alviggi Carlo , Behre Hermann M. , Fischer Robert , Hu Liang , Polyzos Nikolaos P. , Chuderland Dana , Rama Raju Gottumukkala Achyuta , D’Hooghe Thomas , Simoni Manuela , Sunkara Sesh K. , Longobardi Salvatore 
Published: February 2022

BackgroundA Delphi consensus was conducted to evaluate the influence of single nucleotide polymorphisms (SNPs) in genes encoding gonadotropin and gonadotropin receptors on clinical ovarian stimulation outcomes following assisted reproductive technology (ART) treatment.MethodsNine experts plus two Scientific Coordinators discussed and amended statements plus supporting references proposed by the Scientific Coordinators. The statements were distributed via an online survey to 36 experts, who voted on their level of agreement or disagreement with each statement. Consensus was reached if the proportion of participants agreeing or disagreeing with a statement was &gt;66%.ResultsEleven statements were developed, of which two statements were merged. Overall, eight statements achieved consensus and two statements did not achieve consensus. The statements reaching consensus are summarized here. (1) SNP in the follicle stimulating hormone receptor (FSHR), rs6166 (c.2039A&gt;G, p.Asn680Ser) (N=5 statements): Ser/Ser carriers have higher basal FSH levels than Asn/Asn carriers. Ser/Ser carriers require higher amounts of gonadotropin during ovarian stimulation than Asn/Asn carriers. Ser/Ser carriers produce fewer oocytes during ovarian stimulation than Asn/Asn or Asn/Ser carriers. There is mixed evidence supporting an association between this variant and ovarian hyperstimulation syndrome. (2) SNP of FSHR, rs6165 (c.919G&gt;A, p.Thr307Ala) (N=1 statement): Few studies suggest Thr/Thr carriers require a shorter duration of gonadotropin stimulation than Thr/Ala or Ala/Ala carriers. (3) SNP of FSHR, rs1394205 (−29G&gt;A) (N=1 statement): Limited data in specific ethnic groups suggest that A/A allele carriers may require higher amounts of gonadotropin during ovarian stimulation and produce fewer oocytes than G/G carriers. (4) SNP of FSH β-chain (FSHB), rs10835638 (−211G&gt;T) (N=1 statement): There is contradictory evidence supporting an association between this variant and basal FSH levels or oocyte number. (5) SNPs of luteinizing hormone β-chain (LHB) and LH/choriogonadotropin receptor (LHCGR) genes (N=1 statement): these may influence ovarian stimulation outcomes and could represent potential future targets for pharmacogenomic research in ART, although data are still very limited.ConclusionsThis Delphi consensus provides clinical perspectives from a diverse international group of experts. The consensus supports a link between some variants in gonadotropin/gonadotropin receptor genes and ovarian stimulation outcomes; however, further research is needed to clarify these findings.
Long-Term Storage Does Not Affect the Expression Profiles of mRNA and Long Non-Coding RNA in Vitrified-Warmed Human Embryos
Authors: Li Jingyu , Zhu Ling , Huang Jin , Liu Weiwei , Han Wei , Huang Guoning 
Published: February 2022

Although vitrification has been widely applied in assisted reproductive technology, it is unknown whether storage time has any impact on the mRNA and lncRNA expression profiles in human embryos. Eleven women (aged 23–35 years) who had undergone in vitro fertilization treatment were recruited for this study. The transcriptomes of 3 fresh eight-cell embryos and 8 surviving vitrified-warmed eight-cell embryos (4 embryos were cryostored for 3 years, and the others were cryostored for 8 years) were analyzed through single-cell RNA-Seq. No differentially expressed mRNAs or lncRNAs were identified between the 3-years group and 8-years group. A total of 128 mRNAs and 365 lncRNAs were differentially expressed in the 8 vitrified-warmed embryos compared with the fresh embryos. The vitrification-warming impact was moderate, and it was mainly related to the pathways of metabolism, stress response, apoptosis, cell cycle, cell adhesion, and signaling for TFG-β and Hippo. The analysis of target mRNAs suggested that lncRNAs might contribute to the regulation of mRNAs after vitrification-warming. Our findings indicated that long-term storage after vitrification does not affect the mRNA and lncRNA expression profiles in human embryos, however, the procedure of vitrification-warming would lead to minor alteration of transcriptome.
Genome Sequencing for Genetics Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study
Authors: Binquet Christine , Lejeune Catherine , Faivre Laurence , Bouctot Marion , Asensio Marie-Laure , Simon Alban , Deleuze Jean-François , Boland Anne , Guillemin Francis , Seror Valérie , Delmas Christelle , Espérou Hélène , Duffourd Yannis , Lyonnet Stanislas , Odent Sylvie , Heron Delphine , Sanlaville Damien , Frebourg Thierry , Gerard Bénédicte , Dollfus Hélène 
Published: February 2022

Introduction:Intellectual Disability (ID) is the most common cause of referral to pediatric genetic centers, as it affects around 1–3% of the general population and is characterized by a wide genetic heterogeneity. The Genome Sequencing (GS) approach is expected to achieve a higher diagnostic yield than exome sequencing given its wider and more homogenous coverage, and, since theoretically, it can more accurately detect variations in regions traditionally not well captured and identify structural variants, or intergenic/deep intronic putatively pathological events. The decreasing cost of sequencing, the progress in data-management and bioinformatics, prompted us to assess GS efficiency as the first line procedure to identify the molecular diagnosis in patients without obvious ID etiology. This work is being carried out in the framework of the national French initiative for genomic medicine (Plan France Médecine Génomique 2025).Methods and Analysis:This multidisciplinary, prospective diagnostic study will compare the diagnostic yield of GS trio analysis (index case, father, mother) with the French core minimal reference strategy (Fragile-X testing, chromosomal microarray analysis and Gene Panel Strategy of 44 selected ID genes). Both strategies are applied in a blinded fashion, in parallel, in the same population of 1275 ID index cases with no obvious diagnosis (50% not previously investigated). Among them, a subgroup of 196 patients are randomized to undergo GS proband analysis in addition to GS trio analysis plus the French core minimal reference strategy, in order to compare their efficiency. The study also aims to identify the most appropriate strategy according to the clinical presentation of the patients, to evaluate the impact of deployment of GS on the families’ diagnostic odyssey and the modification of their care, and to identify the advantages/difficulties for the patients and their families.Ethics Statement:The protocol was approved by the Ethics Committee Sud Méditerranée I and the French data privacy commission (CNIL, authorization 919361).Trial Registration:ClinicalTrials.govidentifier NCT04154891 (07/11/2019).
Preventive Vitamin A Supplementation Improves Striatal Function in 6-Hydroxydopamine Hemiparkinsonian Rats
Authors: Marie Anaïs , Leroy Julien , Darricau Morgane , Alfos Serge , De Smedt-Peyrusse Veronique , Richard Emmanuel , Vancassel Sylvie , Bosch-Bouju Clementine 
Published: February 2022

BackgroundThe mechanisms leading to a loss of dopaminergic (DA) neurons from the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) have multifactorial origins. In this context, nutrition is currently investigated as a modifiable environmental factor for the prevention of PD. In particular, initial studies revealed the deleterious consequences of vitamin A signaling failure on dopamine-related motor behaviors. However, the potential of vitamin A supplementation itself to prevent neurodegeneration has not been established yet.ObjectiveThe hypothesis tested in this study is that preventive vitamin A supplementation can protect DA neurons in a rat model of PD.MethodsThe impact of a 5-week preventive supplementation with vitamin A (20 IU/g of diet) was measured on motor and neurobiological alterations induced by 6-hydroxydopamine (6-OHDA) unilateral injections in the striatum of rats. Rotarod, step test and cylinder tests were performed up to 3 weeks after the lesion. Post-mortem analyses (retinol and monoamines dosages, western blots, immunofluorescence) were performed to investigate neurobiological processes.ResultsVitamin A supplementation improved voluntary movements in the cylinder test. In 6-OHDA lesioned rats, a marked decrease of dopamine levels in striatum homogenates was measured. Tyrosine hydroxylase labeling in the SNc and in the striatum was significantly decreased by 6-OHDA injection, without effect of vitamin A. By contrast, vitamin A supplementation increased striatal expression of D2 and RXR receptors in the striatum of 6-OHDA lesioned rats.ConclusionsVitamin A supplementation partially alleviates motor alterations and improved striatal function, revealing a possible beneficial preventive approach for PD.
Sodium-Glucose Co-Transporter 2 Inhibitors Use Improves the Satisfaction With Anti-diabetic Agent Treatment: A Questionnaire-based Propensity Score-matched Study
Authors: Shi Fang-Hong , Yue Jiang , Jiang Yi-Hong , Yang Ming-Lan , Gu Zhi-Chun , Ma Jing , Li Hao 
Published: February 2022

Background: Specific safety issues with sodium-glucose co-transporter-2 (SGLT2) inhibitors such as infection, fractures, worsening of renal function and euglycemic ketoacidosis have been raised. Concerns about adverse events might limit the use of this drug class. The satisfaction with SGLT2 inhibitors treatment in Chinese patients with type 2 diabetes mellitus (T2DM) is unknown.Material and Methods: Patients with T2DM who visited the hospital between October 2019 and June 2020 were included in this retrospective analysis. Patients were divided into SGLT2 inhibitors used group or not. The Satisfaction with Oral Anti-Diabetic Agent Scale (SOADAS) questionnaire and self-reported AEs were obtained at 3 months of follow-up. Propensity score matching (PSM) was performed to adjust for confounding factors. Univariate and multivariable linear regression models were used to explore potential risk factors associated with overall satisfaction.Results: A total of 145 T2DM patients were included, with 76 SGLT2 inhibitors users and 69 non-users. Patients administered with SGLT2 inhibitors presented with increased overall satisfaction (mean [SE]: 22.8 [0.67] vs. 20.6 [0.64], p = 0.016) and overall satisfaction rate (n [%]: 40 [52.6%] vs 21 [30.4%], p = 0.007) when compared to other anti-diabetic agents. The use of SGLT2 inhibitors significantly improved satisfaction of glycemic control ability (mean [SE]:3.9 [0.12] vs. 3.5 [0.12], p = 0.027), diabetic symptom’s control ability (3.5 [0.15] vs. 3.0 [0.15], p = 0.027), glycemic control speed (3.9 [0.11] vs. 3.4 [0.12], p = 0.011), medication tolerability (3.9 [0.10] vs. 3.5 [0.12], p = 0.012), and overall satisfaction (4.0 [0.11] vs. 3.6 [0.12], p = 0.037), but it did not improve satisfaction of medication effect on bodyweight (3.8 [0.11] vs. 3.4 [0.11], p = 0.166). After adjusting confounding factors (47 patients for each group), consistent results were obtained. No significant differences of self-reported clinical AEs were observed between SGLT2 inhibitors users and non-users. Multivariable regression analyses verified that the use of SGLT2 inhibitors was associated with increased levels of satisfaction.Conclusions: The use of SGLT2 inhibitors was associated with increased levels of satisfaction in T2DM patients, but not associated with overall clinical safety. Self-reported AEs were not related to the satisfaction with the use of anti-diabetic agents.
The Chinese Inventory of Psychosocial Balance Short-Form Questionnaire for the Older Adults: Validity and Reliability Study
Authors: Chen Pei-Yun , Ho Wen-Chao , Lo Chyi , Yeh Tzu-Pei 
Published: February 2022

BackgroundDrawing from Erikson’s theory, Domino and Affonso constructed the Inventory of Psychosocial Balance (IPB), a scale with satisfactory reliability and validity. However, the lack of a credible Chinese version of the scale may hinder research on ego development in Taiwan. The aim of the present study was to construct a short form Chinese IPB. In addition, factor analysis was employed to shorten the original 120-item scale to make it suitable for application in the older adults in the future.MethodsThe study involved three steps: The first step was to establish the 120-items of the Chinese Inventory of Psychosocial Balance (C-IPB), and we conducted translation, back-translation, expert validity, and reliability of pilot study for this step. Following the first step was to construct the short-form C-IPB (CIPB-SF) in the second step, and the CIPB-SF was developed via item analysis and factor analysis. Finally, we assessed the reliability and validity of the CIPB-SF via structural equation model in the third step.ResultsThree hundred eight older adults without cognitive disorder completed the IPB. The 40-item CIPB-SF was completed through item analysis and factor analysis. The internal consistency test of CIPB-SF and the eight stages were good (Cronbach’s α = 0.81–0.89). The CIPB-SF had acceptable validity, except in the intimacy and identity stages, in which validity was only fair. Compared with the IPB, the CIPB-SF had good reliability and acceptable validity. However, because of its conciseness, the 40-item CIPB-SF was more suited for application among the Chinese elderly population because its application avoids physical overload.ConclusionThe CIPB-SF served as a concise scale for assessing ego development in our study. This scale can also serve as a useful tool for convenient screening in the future.