bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel bis-amide-based bis-thiazoles as Anti-colorectal Cancer Agents Through Bcl-2
Inhibition: Synthesis, In Vitro, and In Vivo studies
Authors: Dawood Kamal M. , Raslan Mohamed A. , Abbas Ashraf A. , Mohamed Belal E. , Nafie Mohamed S. 
Published: June 2022

Background:
Some heterocycles having bisamide linkage are receiving much interest due to their remarkable
biological potencies and they are naturally occurring. Some bisamides and thiazole derivatives were found to inhibit
the protein levels of Bcl-2 significantly. This prompted us to synthesize new bis(heterocyclic) derivatives having
bisamide function to explore their anti-cancer activities.

Method:
Novel bis-amide-based bis-thiazoles and thiadiazoles were synthesized by reaction of a new bisthiosemicarbazone
with a variety of hydrazonoyl chlorides, a-chloroacetylacetone and haloacetic acid derivatives. Most
of the synthesized derivatives were tested for colorectal (HCT-116) and breast (MCF-7) cell lines using the MTT assay,
with the apoptotic investigation through flow cytometric and RT-PCR analyses.

Results:
Some derivatives were found to be highly cytotoxic against HCT-116 cells with an IC50 range of (10.44-13.76
μM) compared to 5-fluorouracil (5-FU) (IC50 = 11.78 μM). One product significantly stimulated apoptotic colorectal
cancer cell death by 27.24-fold (50.13% compared to control 1.84%) by arresting the cell cycle at the G2/M phase. The
obtained results revealed that compound 7f was more cytotoxic against HCT-116 cells than 5-FU. Compound 7f
remarkably enhanced apoptotic colorectal cancer cell death and upregulated the propapoptotic genes (P53, BAX and
Capases-3,-8,-9) and downregulated the anti-apoptotic gene, B-cell lymphoma 2 (Bcl-2). In vivo study exhibited that
7f-treatment caused tumor inhibition ratio (TIR%) of 50.45% compared to 54.86% in the 5-FU treatment, with a
significant reduction in tumor mass and volume. The anti-tumor activity of compound 7f was accompanied by
ameliorated hematological and biochemical analyses, histopathological improvement in treated liver tissues, and the
immunohistochemical staining revealed Bcl-2 inhibition in agreement with the in vitro results.

Conclusion:
Compound 7f is an interesting candidate for further development as a chemotherapeutic anti-cancer agent.
Use of Random Domain Intercept Technology to Track COVID-19 Vaccination Rates in Real Time Across the United States: Survey Study
Authors: Sargent Rikki H , Laurie Shaelyn , Weakland Leo F , Lavery James V , Salmon Daniel A , Orenstein Walter A , Breiman Robert F 
Published: June 2022

Background
Accurate and timely COVID-19 vaccination coverage data are vital for informing targeted, effective messaging and outreach and identifying barriers to equitable health service access. However, gathering vaccination rate data is challenging, and efforts often result in information that is either limited in scope (eg, limited to administrative data) or delayed (impeding the ability to rapidly respond). The evaluation of innovative technologies and approaches that can assist in addressing these limitations globally are needed.

Objective
The objective of this survey study was to assess the validity of Random Domain Intercept Technology (RDIT; RIWI Corp) for tracking self-reported vaccination rates in real time at the US national and state levels. RDIT—a form of online intercept sampling—has the potential to address the limitations of current vaccination tracking systems by allowing for the measurement of additional data (eg, attitudinal data) and real-time, rapid data collection anywhere there is web access.

Methods
We used RDIT from June 30 to July 26, 2021, to reach a broad sample of US adult (aged ≥18 years) web users and asked questions related to COVID-19 vaccination. Self-reported vaccination status was used as the focus of this validation exercise. National- and state-level RDIT-based vaccination rates were compared to Centers for Disease Control and Prevention (CDC)–reported national and state vaccination rates. Johns Hopkins University’s and Emory University’s institutional review boards designated this project as public health practice to inform message development (not human subjects research).

Results
By using RDIT, 63,853 adult web users reported their vaccination status (6.2% of the entire 1,026,850 American web-using population that was exposed to the survey). At the national level, the RDIT-based estimate of adult COVID-19 vaccine coverage was slightly higher (44,524/63,853, 69.7%; 95% CI 69.4%-70.1%) than the CDC-reported estimate (67.9%) on July 15, 2021 (ie, midway through data collection; t63,852=10.06; P<.001). The RDIT-based and CDC-reported state-level estimates were strongly and positively correlated (r=0.90; P<.001). RDIT-based estimates were within 5 percentage points of the CDC’s estimates for 29 states.

Conclusions
This broad-reaching, real-time data stream may provide unique advantages for tracking the use of a range of vaccines and for the timely evaluation of vaccination interventions. Moreover, RDIT could be harnessed to rapidly assess demographic, attitudinal, and behavioral constructs that are not available in administrative data, which could allow for deeper insights into the real-time predictors of vaccine uptake–enabling targeted and timely interventions.
Optimalisasi Individual Effort, Organizational Effort dan Environment Effort Pemuda Karang Taruna Dalam Meningkatkan Daya Tanggap (Responsiveness) Kondisi Darurat Wabah COVID-19
Authors: Murharyati Atiek , Sulisetyowati Dwi , Pratiwi Erinda Nur , Nurjanah Siti 
Published: June 2022

Taruna coral organization has an important role to face the Covid 19 outbreak, because it has good resilience and a reliable way of thinking,so that it can be done optimization of taruna coral organization in keeping the spread of Covid 19 is not more widespread. Based on this, the youth of taruna coral needs strengthening of the organization so that it will increase the powerof the ladder p(responsiveness) smart youth. The purpose of community service is to strengthen the organization of taruna coral so that it can become an organization that has high responsiveness to the environmental situation due to Covid through the strengthening of individual efforts, organizational efforts and environment efforts. Some things that need to be strengthened are individual effort, organizational effort and environment effort. The method is done by educating young people in the form of lectures and mentoring activities in the face of the Covid 19 pandemic outbreak. The results were realized that after the education of 100% members of taruna coral realize and know the importance of strengthening the organization through strengthening individual effort, organizational effort and environment effort. And after mentoring activities in the form of social service, 100% of taruna coral members are able to do activities as a form of responsiveness to the occurrence of the covid 19 outbreak, namely by the form of social service activities of distribution of foodstuffs and Brochures covid 19 to citizens. The conclusion is that taruna coral organizations can run programs by fostering and strengthening individual efforts, organizational efforts and environment efforts so as to have responsiveness to the environmental situation due to Covid 19.
Perlindungan Hukum Terhadap Anak Yang Berada Di Wilayah Perang Menurut Konvensi Jenewa 1949 Dengan Protokol Tambahan 1977
Authors: Amini Intan , Perbrianto Dony Yusra 
Published: June 2022

Artikel ini membahas bagaimana perlindungan terhadap anak-anak yang berada di wilayah konflik bersenjata. Perlindungan anak telah diatur pada Konvensi Jenewa 1949, Protokol Tambahan 1977, International Convention on The Rights of Childs 1989, Optional Protocol on Involvent of Children in Armed Conflict 2000. Namun, para pihak yang berkonflik masih melanggar prinsip pembedaan, prinsip pembatasan, prinsip keseimbangan, dan prinsip perlindungan yang berlaku dalam hukum humaniter internasional. Padahal, Hukum Humaniter melarang penduduk sipil dijadikan sebagai objek kekerasan dan wajib diberikan perlindungan dari segala hal yang berkaitan dengan peperangan. Sedangkan kombatan dapat dijadikan objek kekerasan saat berperang tetapi tetap wajib diberikan perlindungan ketika menjadi tawanan perang. Sebagai bentuk tanggung jawab negara, maka sanksi pidana dan ganti rugi perlu diterapkan demi menjamin kepastian hukum dan memberikan keadilan bagi para pihak yang menjadi korban menurut hukum humaniter.
Legitimasi Hukuman Mati: Perlukah Mandatory Consular Notification Antar Negara?
Authors: Fatriani Lendra , Sipahutar Bernard 
Published: June 2022

Artikel ini mempertanyakan bagaimana praktik Mandatory Consular Notification yang diterapkan oleh Kerajaan Arab Saudi terhadap Indonesia dalam menyelamatkan tenaga kerja yang dijatuhi hukuman mati. Mandatory Consular Notification adalah hak untuk memperoleh informasi dan akses terkait perwakilan negara atas warga negaranya serta hak warga negara atas staf perwakilan negara. Ini merupakan pedoman utama dalam tata laksana hubungan internasional yang telah diatur di Pasal 36 dan Pasal 37 Konvensi Wina 1963. Dalam pelaksanaannya, Kerajaan Arab Saudi tidak melakukan Mandatory Consular Notification sesuai ketentuan yang berlaku. Oleh karena itu Indonesia perlu memastikan upaya-upaya perlindungan hukum terhadap tenaga kerjanya dengan cara melakukan Memorandum of Understanding dengan Kerajaan Arab Saudi. Selain itu, Indonesia juga perlu mengupayakan langkah hukum lain khususnya dalam bentuk perjanjian agar tercipta kepastian hukum diantara negara pihak.
PENGELOLAAN FILANTROPI ISLAM DI TENGAH PANDEMI COVID-19 (STUDI PADA KOMUNITAS KURIR SEDEKAH)
Authors: Efendi Mansur 
Published: June 2022

Â Covid-19 pandemic which happened to most of countries have been heavily affected many sectors, especially economy. Social distancing policy in Indonesia implicated on businesses activities degression. Many companies have to do a layoff policy. Another issues also appeared when positive patients must be quarantined. Economic issues that appear during pandemics triggered many philanthropy movement in Indonesia to be founded, one of them is Komunitas Kurir Sedekah (Charity Courier Community). The appearance of Komunitas Kurir Sedekah added diversity of Islamic philanthropy movement in Indonesia. Their crowd fundind and recipients targeting program is practical, efficient and directly involving all members. With this approach, all members of community had strong sense of belonging. Meanwhile, funds distribution directed to overcome to short term and temporary humanity issues. At least, the appearance of Komunitas Kurir Sedekah capable to overcome government's temporary program's problematics. Furthermore, this community can raise community awareness to do charity during pandemics.Â Â Pandemi Covid-19 yang terjadi hampir di semua negara, telah memberikan dampak yang cukup berat pada sendi kehidupan, khususnya sektor ekonomi. Demikian halnya dengan Indonesia, kebijakan pembatasan aktivitas bagi masyarakat (social distancing) berimplikasi pada penurunan kegiatan bisnis. Beberapa perusahaan terpaksa melakukan Pemutusan Hubungan Kerja (PHK). Persoalan lain juga nampak pada masyarakat yang dinyatakan positif dan harus dirawat serta dikarantina. Persoalan ekonomi yang muncul sebagai akibat Pandemi Covid-19, merangsang lahirnya gerakan filantropi di Indonesia, salah satunya adalah Komunitas Kurir Sedekah. Keberadaan Komunitas Kurir Sedekah menambah keragaman gerakan filantropi Islam di Indonesia. Sasaran penerima program dan penghimpunan dana dilakukan secara praktis, cepat dan melibatkan langsung anggota. Dengan pendekatan seperti ini, maka rasa kepemilikan (sense of belonging) anggota terhadap komunitas akan semakin kuat. Sedangkan penyaluran dana diarahkan pada persoalan kemanusiaan yang bersifat jangka pendek. Hadirnya Komunitas Kurir Sedekah setidaknya mampu menjawab problematika program pemerintah yang sifatnya temporer. Lebih jauh, keberadaannya juga mampu meningkatkan kesadaran masyarakat untuk tetap berbagi di tengah pandemi.
ANALISIS STRATEGI FUNDRAISING ORGANISASI PENGELOLA ZAKAT DI ERA DIGITALISASI
Authors: Yuliar Ade 
Published: June 2022

Zakat potential in Indonesia is very large, but the potential has not been explored optimally. One of the challenges is how zakat institutions create innovative strategies of collecting zakat in accordance with the current millennial era. This study aims to analyze zakat fundrasing models that have been done by zakat institutions and also attempt to propose solutions to optimize zakat funding in the digital era. The results of the research formulate that digital era funding strategy must be in line with the revolutionary spirit of industry 4.0 characterized by digital-based. So far the fundraising strategy is not yet new, that is still conservative for example: not yet make the website become based on android, so website more accessible. Zakat institutions also should innovates zakat payment cooperation as online zakat (online payment or e-payment), for example cooperation through fintech and e-commerce. Suggestions and conclusions that all zakat institutions have similarities, no new strategy and zakat institutions should innovate in strategy.Â Potensi zakat di Indonesia sangat besar, namun potensi tersebut belum tergarap secara maksimal. Salah satu tantangannya adalah bagaimana lembaga zakat menciptakan strategi inovatif dalam menghimpun zakat sesuai dengan era milenial saat ini. Penelitian ini bertujuan untuk menganalisis model-model fundrasing zakat yang telah dilakukan oleh lembaga zakat dan juga berupaya memberikan solusi untuk mengoptimalkan pendanaan zakat di era digital. Hasil penelitian merumuskan bahwa strategi pendanaan era digital harus sejalan dengan semangat revolusioner industri 4.0 yang bercirikan berbasis digital. Sejauh ini strategi fundraising masih belum baru, yaitu masih konservatif misalnya: belum menjadikan website berbasis android, sehingga website lebih mudah diakses. Lembaga zakat juga harus melakukan inovasi kerjasama pembayaran zakat sebagai zakat online (pembayaran online atau e-payment), misalnya kerjasama melalui fintech dan e-commerce. Saran dan kesimpulan bahwa lembaga zakat memiliki kesamaan,yaitu tidak ada strategi baru dan lembaga zakat harus berinovasi dalam strategi fundraising.
NILAI FILANTROPI: SEBUAH TINJAUAN PELAKSANAAN AKAD QARDHUL HASAN DI MASA PANDEMI
Authors: Murdianto Wahidin 
Published: June 2022

BMT Tumang Boyolali is a non-bank Islamic financial institution. Baitul Maal wa Tamwil is an institution that runs two fields, namely business through Tamwil and social through maal. One of the social programs at Baitul Maal at BMT Tumang is an economic empowerment program, namely Pokusma. The main problem raised regarding the implementation of the qardhul hasan contract used in the maal program is reviewed with maqashid shari'ah during the covid-19 pandemic, namely the suitability of the implementation of the contract with existing provisions and the fulfillment of maqashid shari'ah values in the use of the qardhul hasan contract in the field of Maal BMT Tumang Boyolali Center during the covid-19 pandemic. Thus it will be known how the qardhul hasan contract is used in the maal program in the midst of the Covid-19 pandemic. The review of maqashid shari'ah on the implementation of the qardhul hasan contract during the covid-19 pandemic will reveal the extent to which the values of maqashid sharia and maqashid qardh are being fulfilled.

BMT Tumang Pusat Boyolali merupakan lembaga keuangan syariah non Bank. Baitul Maal wa Tamwil merupakan lembaga yang menjalankan dua bidang, yakni bisnis melalui tamwil dan sosil melalui maal. Salah satu program sosial pada baitul maal di BMT Tumang adalah program pemberdayaan ekonomi yaitu pokusma. Masalah utama yang diangkat perihal pelaksanaan akad qardhul hasan yang digunakan pada program maal ditinjau dengan maqashid syariah di masa pandemi covid-19 yakni kesesuaian pelaksanaan akad dengan ketentuan yang ada dan pemenuhan nilai-nilai maqashid syariah dalam penggunaan akad qardhul hasan dalam bidang maal BMT Tumang Pusat Boyolali di masa pandemi covid-19. Dengan demikian akan diketahui bagaimana penggunaan akad qardhul hasan pada program maal di tengah pandemi Covid-19. Tinjauan maqashid syariah terhadap pelaksanaan akad qardhul hasan di masa pandemi covid-19 akan diketahui sejauh mana pemenuhan nilai-nilai maqashid syariah dan maqashid qardh.
The Role of QRSL1 in Clinical Subtypes and Prognosis of Childhood B-cell Acute Lymphoblastic Leukemia
Authors: Yin Sha , Gao Wenjin , Fan Ye , Xia Rui , Duan Mingyue , Zhang Xi , Liu Ansheng , Zhang Yanmin 
Published: June 2022

B-cell acute lymphoblastic leukemia (B-ALL) is the most common leukemia
in the pediatric population, caused by a malignant clonal proliferation
of B lymphoid progenitor cells. Identifying new molecular markers
related to B-cell development is helpful for investing the pathogenesis
of B-ALL, and is potentially important for clinical prognosis. We found
that B cells showed the highest expression of glutaminyl-tRNA
amidotransferase subunit QRSL1 (QRSL1) compared with other cells during
the differentiation and development of hematopoietic stem cells and the
expression of QRSL1 also gradually increases with the development of
human fetal B-cell. Moreover, QRSL1 expression was higher in the tissues
and cell lines extracted from patients with B-ALL than in corresponding
control tissues. In the TARGET cohort, EFS and OS decreased in B-ALL
with high expression of QRSL1, suggesting that QRSL1 was an independent
prognostic factor. And high QRSL1 expression is associated with more
bone marrow sites of relapse and TCF3-PBX1 gene fusions. Then analyzing
the gene expression of the TCF3-PBX1 gene fusion subgroup, the
significantly different gene expression between the QRSL1
group and QRSL1 group
exhibited enrichment in cell development, suggesting that QRSL1 may
participate in leukemic cell development in childhood B-ALL. Therefore,
QRSL1 may be a molecule related to B cell development and is associated
with molecular subtypes of B-ALL. The high expression of QRSL1 is
associated with poor prognosis in patients with B-ALL, showing its
potential as a prognostic marker of B-ALL leukemia.
CHCHD10 Modulates Thermogenesis of Adipocyte by Regulating Lipolysis
Authors: Ding Meng , Ma Yin-jun , Du Ruo-qi , Zhou Wei-yu , Dou Xin , Yang Qi-qi , Tang Yan , Qian Shu-wen , Liu Yun , Pan Dong-ning , Tang Qi-Qun , Liu Yang 
Published: June 2022

<p> </p>
<p>Brown and beige adipocytes dissipate energy in a non-shivering thermogenesis manner, exerting beneficial effects on metabolic homeostasis. CHCHD10 is a nuclear-encoded mitochondrial protein involved in cristae organization; however, its role in thermogenic adipocytes remains unknown. Herein, we identify CHCHD10 as a novel regulator for adipocyte thermogenesis. CHCHD10 is dramatically upregulated during thermogenic adipocytes activation by PPARγ-PGC1α, and positively correlated with UCP1 expression in the adipose tissues from human and mice. We generate adipocyte-specific <em>Chchd10</em> knockout mice (<em>Chchd10</em>-AKO) and find that depleting CHCHD10 leads to impaired UCP1-dependent thermogenesis and energy expenditure in the fasting state, with no effect in fed state. Lipolysis in adipocytes is disrupted by CHCHD10 deficiency, while augmented lipolysis via ATGL overexpression recovers adipocyte thermogenesis in <em>Chchd10</em>-AKO mice. Consistently, overexpression of <em>Chchd10</em> activates thermogenic adipocytes. Mechanistically, CHCHD10 deficiency results in the disorganization of mitochondrial cristae, leading to impairment of oxidative phosphorylation complex assembly in mitochondria, which in turn inhibits ATP generation. Decreased ATP results in downregulation of lipolysis by reducing nascent protein synthesis of ATGL, thereby suppressing adipocyte thermogenesis. As a result, <em>Chchd10</em>-AKO mice are prone to develop high-fat diet-induced metabolic disorders. Together, our findings reveal essential role of CHCHD10 in regulating lipolysis and thermogenic program in adipocytes.</p>
FUNERAL RITES OF KET AND NAVAJO INDIANS: EXPERIENCE OF HISTORICAL AND ETHNOGRAPHIC COMPARISON
Authors: Николаев Вячеслав Романович 
Published: June 2022

В статье проведен сравнительный анализ погребально-поминальной обрядности кетов (представителей енисейской языковой семьи) и индейцев навахо (представителей языковой семьи на-дене) с целью выявления в этих обрядах каких-либо культурных сходств и связей для сбора данных, позволяющих впоследствии анализировать характер самих этих связей. В результате автором статьи были получены выводы о том, что среди характеристик в погребально-поминальном обряде кетов и индейцев навахо есть как существенные (захоронения на лабазе и на дереве, объяснение смертности человека, ориентация умершего), так и менее существенные сходства. Некоторые элементы сходства в погребально-поминальных обрядах сравниваемых этносов позволяют (с большой осторожностью) оценить имеющиеся черты сходства как носящие характер культурно-генетических, что может стать неким дополнительным аргументом в пользу теории о родстве индейцев на-дене и енисейцев.
The study is carried out a comparative analysis of the memorial and funeral rites of the Indians of the Na-Dene (Navajo) group and the Yenisei (Kets). The purpose of this study is to conduct a comparative analysis of ethnographic material in order to identify any cultural similarities and parallels in the memorial and funeral rites of the Navajo Indians and Kets and to collect data that would allow to analyze the nature of these ties themselves afterwards. As a result, the author of the article reached the conclusions that among the characteristics in the funeral ritual of the Kets and Navajo Indians there are both principal (the burials in a warehouse and on a tree, an explanation of human mortality and the orientation of the deceased in an eastern direction) and insignificant similarities among the characteristics in the funeral rituals of the Kets and Navajo Indians. There are cultural ties in memorial and funeral rites that allow (with great caution) to evaluate the existing similarities as cultural and genetic, which may become an additional argument in favor of the theory of the Na-Dene Indians’ and the Yenisei’s kinship.
KETAHANAN PANGAN RUMAH TANGGA PETANI KELAPA SAWIT SWADAYA DI KABUPATEN TULANG BAWANG
Authors: Aisy Alifia Marsa , Haryono Dwi , Ismono Raden Hanung 
Published: June 2022

The aims of this research are to analyze the level of food security, the factors that affect the level of food security, and efforts to increase the level of food security of palm oil farmer households (POFH). The research was conducted using a survey method in Tulang Bawang Regency by involving 67 respondents from POFH who were chosen by a simple random sampling. The results of the research showed that 47.76 percent of POFH were categorized as the most secure of food, 29.85 percent as less secure, 20.90 percent as vulnerable, and 1.49 percent as food insecure. The factors that positively affect household food security were household income, formal education level of household head, and ethnicity. The factor that negatively affect household food security was the the number family members. The efforts to increase the level of food security by Government were monitoring the stock of rice, drafting food balance, Programs called Pengembangan Usaha Pangan Masyarakat (PUPM), Kawasan Rumah Pangan Lestari (KRPL) and Modal Pengembangan Pangan Pokok Lebel (MP3L). The efforts of palm oil farmer households were owing groceries (47.50%), do outside work of palm oil farmer (50.62%), and changing dietary habit (1.88%). Key words: cross-classification, food security, palm oil households.