bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fructose‐Coated Ångstrom Silver Particles Suppress Gastric Cancer Growth by Activating Gasdermin D‐Mediated Pyroptosis
Authors: Li You‐You , Xia Kun , Liu Yi‐Wei , Tan Yi‐Juan , Li Hong‐Ming , Wang Yi‐Yi , Feng Shi‐Kai , Jin Ling , Wan Teng‐Fei , Cao Jia , Chen Chun‐Yuan , Liu Zheng‐Zhao , Hu Xiong‐Ke , Wu Ben , Wang Yang , He Ze‐Hui , Yin Hao , Situ Wei‐Yi , Qi Lu‐Yue , Wang Zhen‐Xing , Xie Hui 
Published: October 2022

AbstractGastric cancer (GC) remains an important cancer worldwide, ranking fifth for incidence and fourth for mortality globally. Surgery combined with chemotherapy is recognized as a curative regimen for GC. However, much safer and more effective methods should be developed to improve the survival rate. Formerly, a pure physical method is presented to prepare Ångstrom‐scale silver particles (AgÅPs) and anticancer effects of fructose‐coated AgÅPs (F‐AgÅPs) are found. In this research, the efficacy and alternative pyroptosis induction of F‐AgÅPs in the treatment of GC are investigated and compared with those of cisplatin in subcutaneous GC tumor‐bearing nude mice. F‐AgÅPs inhibit GC cell growth, promote lactate dehydrogenase (LDH) release, and induce cell pyroptosis in vitro. The caspase‐1 selective inhibitor belnacasan (VX‐765) and the pyroptotic pore formation inhibitor necrosulfonamide (NSA) partially reverse F‐AgÅP‐induced pyroptosis in GC cells. In vivo, F‐AgÅPs significantly upregulate inflammasome formation, caspase‐1 expression, and gasdermin D (GSDMD) cleavage, thus inducing pyroptosis. Furthermore, intravenous and oral administrations of F‐AgÅPs do not induce any obvious toxicities in healthy tissues. This study indicates that GSDMD‐dependent pyroptosis is a novel mechanism by which F‐AgÅPs protect against GC in vitro and in vivo, which may provide a new therapeutic strategy for anti‐GC treatment.
Mixed oxygen ionic‐carbonate ionic conductor membrane reactor for coupling CO2 capture with in situ methanation
Authors: Pang Bingjie , Zhang Peng , Cao Zhongwei , Wang Song , Tong Jingjing , Zhu Xuefeng , Yang Weishen 
Published: October 2022

AbstractCO2 methanation is one of the vital reactions to utilize CO2 and realize power to gas process. To decrease the CO2 capture cost and alleviate the hot spots during the strong exothermic methanation reaction, here, we report a coupling of CO2 capture process with in situ CO2 methanation process through a ceramic‐molten carbonate (MC) dual phase membrane reactor over the Ni‐based catalyst. The performance of the membrane reactor was systematically investigated and compared with the traditional fixed‐bed reactor. The results show that the performance of the membrane reactor is higher than that of the fixed‐bed reactor, since the produced steam through the methanation process can be partially removed through the dual‐phase membrane, which promotes the reaction shift to right side. A stability test shows no obvious degradation within 32 h. These results indicate that the membrane reactor is promising for coupling CO2 capture with in situ methanation process.
Photo‐induced Cobalt‐catalyzed Aerobic N−N Coupling of Diarylamines at Room Temperature
Authors: Luo Guanzhong , Han Yu , Zhang Ruohan , Ding Dongmiao , Dian Longyang 
Published: October 2022

AbstractWe report herein a photo induced Co‐catalyzed aerobic N−N coupling of diarylamines to form the corresponding tetraarylhydrazines. In this protocol, the N−N coupling reactions could be realized under mild conditions in the presence of Co(OAc)2 ⋅ 4H2O and BPhen with the irradiation of light (390–395 nm).
Ionic‐liquid grafted poly(vinylidene fluoride) with pH responsiveness using as water treatment separation membranes for multi‐dye retention and adsorption
Authors: Liu Hongxu , Xie Junhao , Zhao Jingxuan , Xue Peng , Wang Ruijia , Lv Xue , Sun Shulin 
Published: October 2022

AbstractThe rapid development of the world economy and industry brings us a higher standard of living and also causes severe water pollution at the same time. Herein, pH‐responsive 1‐allyl‐3‐methylimidazole acetate grafted poly(vinylidene fluoride) membranes (PVDF‐g‐IL) were prepared by high‐energy electron irradiation grafting and non‐solvent‐induced microphase separation technology. The corresponding pH‐responsive membranes can be used to separate dye wastewater with different charges by converting the positive and negative nature of the membrane surface charge. Moreover, the grafted 1‐allyl‐3‐methylimidazole acetate offers a reversible wettability switching ability in different acidic and alkaline environments. The results showed that membrane porosity and average pore size become more prominent, and the pure water flux increases from 121 to 622 Lm−2 h−1. The functionalized membranes exhibited excellent filtration performance of cationic and anionic dyes wastewater by transforming the positive and negative surface charge. The optimum PVDF‐g‐IL membrane displayed a nearly 100% rejection and flux recovery rate. Furthermore, PVDF‐g‐IL membranes exhibited both adsorption and desorption properties for dyes with high adsorption and desorption rates at different pH values. The present research provides a practical and straightforward preparation method of pH‐responsive PVDF‐g‐IL membranes and can apply in the field of dye wastewater purification.
Conductive polymer‐based coating layer on copper current collector for enhanced performance of Li‐ion battery
Authors: Goyal Megha , Bhatnagar Nitu 
Published: October 2022

AbstractThe conductive polymer electrodes are considered as the best fabrication in the production of rechargeable batteries. The idea underlying its use, as well as the process and foundation of cell fabrications based on various types of conducting polymer systems are discussed in this review. Various types of conductive polymer coating on anode current collector along with different routes to provide desirable coated layers are discussed in detail. This review shows that the modified copper current collector can be regarded as an effective protective layer against solid electrolyte interface (SEI) film, electrode particle cracking, cathode electrolyte formation (CEI), dendrite formation/lithium plating, electrolyte decomposition, etc. not only because of their productivity, availability, but also for their stability, cost‐efficiency, and helps to decrease the internal resistance as well.
Mechanical flexible epoxy resins with 100% bio‐based carbon content based on epoxidized vegetable oils
Authors: Schwaiger Markus , Resch‐Fauster Katharina 
Published: October 2022

AbstractThis work describes the development and characterization of mechanical flexible epoxy resins based on epoxidized vegetable oils (EVO) and sebacic acid. Different oil types (linseed oil, hempseed oil, and soybean oil) with varying epoxy equivalent weight (EEW) were used. Formulation and processing parameters were systematically optimized by differential scanning calorimetry and Fourier‐transform infrared spectroscopy. The effect of the EVO type and EEW on thermo‐mechanical and mechanical properties were investigated by dynamic mechanical analysis and tensile tests at different temperatures. The EVO type had a strong effect on the thermo‐mechanical and mechanical properties of the resin. However, for the investigated commercial epoxidized linseed oils, the EEW had no effect on these properties. With epoxidized linseed oil the highest Tg and the best mechanical properties (highest tensile strength and toughness) were achieved.
The role of the efflux transporter, P‐glycoprotein, at the blood–brain barrier in drug discovery
Authors: Cox Benoit , Nicolaï Johan , Williamson Beth 
Published: October 2022

AbstractThe blood–brain barrier (BBB) expresses a high abundance of transporters, particularly P‐glycoprotein (P‐gp), that regulate endogenous and exogenous molecule uptake and removal of waste. This review discusses key drug metabolism and pharmacokinetic considerations for the efflux transporter P‐gp at the BBB in drug discovery and development. We highlight the differences in P‐gp expression and protein levels across species but the limited observations of species‐specific substrates. Given the impact of age and disease on BBB biology, we summarise the modulation of P‐gp for several neurological disorders and ageing and exemplify several disease‐specific hurdles or opportunities for drug exposure in the brain. Furthermore, the review includes observations of CNS‐related drug‐drug interactions due to the inhibition or induction of P‐gp at the BBB in animal studies and humans and the need for continued evaluation especially for compounds with a narrow therapeutic window. This review focusses primarily on small molecules but also considers the impact of new chemical entities, particularly beyond Ro5 molecules and their potential to be recognised as P‐gp substrates as well as advanced drug delivery systems which offer an alternative approach to achieve and sustain central nervous system exposure.
Development of stability‐indicating method for separation and characterization of benidipine forced degradation products using LC–MS/MS
Authors: Kushwah Bhoopendra Singh , Thummar Mohit M. , Yadav Amrej Singh , Dhiman Vivek , Samanthula Gananadhamu 
Published: October 2022

AbstractThe present study describes forced degradation of benidipine (BEN) as per Q1A (R2) and Q1B guidelines of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. BEN degraded under hydrolysis (neutral, acidic, and alkaline), hydrogen peroxide induced oxidation, and UV light mediated photolytic degradation. A total of 14 degradation products (DPs) were found in all degradation studies, comprising 4 hydrolytic DPs, 8 oxidative DPs, and 4 photolytic DPs. A selective stability‐indicating method was developed using an XBridge BEH C18 column with gradient elution program consisting of ammonium acetate (10 mM, 4.8 pH, acetic acid) and acetonitrile. The flow rate was maintained at 1 ml min−1. All DPs were separated well using the developed HPLC method and were characterized using LC–MS/MS data. As this method is effective in identifying and separating BEN and its DPs with sufficient resolution, it can be used in laboratories for quality control of drugs in daily routine analysis and stability studies.
Research progress in the establishment of pancreatic cancer models and preclinical applications
Authors: Wu Weizheng , Wen Kunming , Zhong Yuxin 
Published: October 2022

AbstractPancreatic cancer (PC) is a highly malignant tumor in the digestive system. The transformation of tissue from normal to pancreatic intraepithelial neoplasm is driven by certain oncogenes, among which the mutation rate of the KRAS gene is as high as 90%. Currently, PC has limited treatment options, low therapeutic effects, and poor prognosis. Thus, more effective methods to combat PC are urgently needed. Some models that can more accurately reflect the biological behaviors and genomic characteristics of PC, such as its morphology, pathology, proliferation, and invasion, are being continuously developed. These include genetic engineering models, orthotopic xenograft models, and heterotopic xenograft models. Using these PC models, scientists have further verified promising drugs and potential therapeutic targets for PC treatment. This is of great significance for limiting the progression of PC with clinical intervention, improving patient outcomes, and improving survival rates.
Clinical impact of early response to first‐line VEGFR‐TKI in patients with metastatic renal cell carcinoma on survival: A multi‐institutional retrospective study
Authors: Sobu Ryuta , Numakura Kazuyuki , Naito Sei , Hatakeyama Shingo , Kato Renpei , Koguchi Tomoyuki , Kojima Takahiro , Kawasaki Yoshihide , Kandori Syuya , Kawamura Sadafumi , Arai Yoichi , Ito Akihiro , Nishiyama Hiroyuki , Kojima Yoshiyuki , Obara Wataru , Ohyama Chikara , Tsuchiya Norihiko , Habuchi Tomonori 
Published: October 2022

AbstractIt remains unknown whether the early response to vascular endothelial growth factor receptor tyrosine kinase inhibitor (VEGFR‐TKI) management in malignancies links to long‐term survival. The objective of this study was to investigate the survival rates and predictive factors of early response in patients with metastatic renal cell carcinoma (mRCC) managed by VEGFR‐TKIs. From Jan. 2008 to Oct. 2018, 496 patients were treated with VEGFR‐TKIs as first‐line treatment at the eight Japanese hospitals (Michinoku RCC). Early cessation was defined as VEGFR‐TKIs being given up within 3 months after their initiation. The number of patients in early cessation VEGFR‐TKIs (Cohort I) was 173 (34.9%), and in long‐term use (Cohort II) was 323 (65.1%). The cancer‐specific survival (CSS) and overall survival (OS) were better in Cohort II. IMDC Poor‐risk was at risk of early cessation of a first‐line VEGFR‐TKI. Axitinib was the most preferred drug for long‐term treatment. On closer examination, both Cohort I and II were divided into two groups, the patients ceased VEGFR‐TKI due to adverse events (Group A [67 from Cohort I] and Group C [51 from Cohort II]) and disease progression (Group B [106 from Cohort I] and Group D [272 from Cohort II]). Despite that the cessation was adverse events, CSS and OS in Group A were worse than both Group C and D. Axitinib was administered with the safer profile. IMDC Poor risk was the risk factor for the early disease progression. Managing early adverse events may contribute to a better prognosis in mRCC patients treated VEGFR‐TKIs.
Herpetic endotheliitis and stromal keratitis following inactivated COVID‐19 vaccination
Authors: Mohammadpour Mehrdad , Farrokhpour Hossein , Sadeghi Reza 
Published: October 2022

AbstractGiven the scarcity of data regarding ocular complications following COVID‐19 vaccination, the approach toward patients with suggestive symptoms and established clinical practice is lacking. Herein, we report the first case of herpetic endotheliithis and secondary stromal keratitis following inactivated COVID‐19 vaccination who experienced a relapse due to poor adherence.
Persistent headaches sometimes concern incidental findings: A rare case of internal jugular vein agenesis in a 32‐year‐old man
Authors: Amin Mohammad Ashraful , Nahin Sabrina , Hawlader Mohammad Delwer Hossain 
Published: October 2022

AbstractAbsence of an internal jugular vein at birth is infrequent. These developmental anomalies affect approximately 0.05 percent to 0.25 percent of the population in the general community. Avascular abnormalities emerging from the internal jugular vein were detected during radiographic studies of chronic headache in an adult male patient. A dull headache troubled a 32‐year‐old man for more than 20 years. After taking most of NSAIDs and other medications for the condition, which persisted, a diagnosis of left internal jugular vein agenesis was made, which was most likely the cause of the headaches. When treating recurrent, persistent headaches in the emergency room and outdoor medical services, keep in mind that agenesis of the jugular venous system can play a role—one of the uncommon causes of headaches we have observed in our cases.
A Homogeneous‐Heterogeneous Kinetic Study of Oxidative Coupling of Methane (OCM) on La2O3/CeO2 Catalyst
Authors: Wang Haoyi , Yang Chaobo , Shao Can , Alturkistani Sultan , Magnotti Gaetano , Gascon Jorge , Takanabe Kazuhiro , Sarathy S. Mani 
Published: October 2022

AbstractA La2O3/CeO2 catalyst was synthesized and achieved 19 % C2+ yield with 65 % C2+ selectivity at 650 °C. The doping of CeO2 not only enhanced catalytic performance, but also improved catalyst stability in the presence CO2 and H2O. This study investigated the kinetics on La2O3/CeO2 over a wide range of operating conditions. Planar laser‐induced fluorescence was implemented to directly observe the presence of formaldehyde, as the first time reported in OCM. A packed bed reactor model was constructed based on the dimensions of experimental setup and catalyst characterization. Rather than using a tuned gas phase model, the experimentally validated mechanism NUIGMech1.1 was implemented. The proposed homogeneous‐heterogeneous OCM mechanism kinetic model was validated against experimental data under isothermal conditions, and the results show good agreement with measured species. The rate of production (ROP) was performed to identify the important reactions and prove the necessity of surface reactions for the OCM process.
Phenology and plasticity can prevent adaptive clines in thermal tolerance across temperate mountains: The importance of the elevation‐time axis
Authors: Gutiérrez‐Pesquera Luis Miguel , Tejedo Miguel , Camacho Agustín , Enriquez‐Urzelai Urtzi , Katzenberger Marco , Choda Magdalena , Pintanel Pol , Nicieza Alfredo G. 
Published: October 2022

AbstractCritical thermal limits (CTmax and CTmin) decrease with elevation, with greater change in CTmin, and the risk to suffer heat and cold stress increasing at the gradient ends. A central prediction is that populations will adapt to the prevailing climatic conditions. Yet, reliable support for such expectation is scant because of the complexity of integrating phenotypic, molecular divergence and organism exposure. We examined intraspecific variation of CTmax and CTmin, neutral variation for 11 microsatellite loci, and micro‐ and macro‐temperatures in larvae from 11 populations of the Galician common frog (Rana parvipalmata) across an elevational gradient, to assess (1) the existence of local adaptation through a PST‐FST comparison, (2) the acclimation scope in both thermal limits, and (3) the vulnerability to suffer acute heat and cold thermal stress, measured at both macro‐ and microclimatic scales. Our study revealed significant microgeographic variation in CTmax and CTmin, and unexpected elevation gradients in pond temperatures. However, variation in CTmax and CTmin could not be attributed to selection because critical thermal limits were not correlated to elevation or temperatures. Differences in breeding phenology among populations resulted in exposure to higher and more variable temperatures at mid and high elevations. Accordingly, mid‐ and high‐elevation populations had higher CTmax and CTmin plasticities than lowland populations, but not more extreme CTmax and CTmin. Thus, our results support the prediction that plasticity and phenological shifts may hinder local adaptation, promoting thermal niche conservatism. This may simply be a consequence of a coupled variation of reproductive timing with elevation (the “elevation‐time axis” for temperature variation). Mid and high mountain populations of R. parvipalmata are more vulnerable to heat and cool impacts than lowland populations during the aquatic phase. All of this contradicts some of the existing predictions on adaptive thermal clines and vulnerability to climate change in elevational gradients.
The terroir of the finch: How spatial and temporal variation shapes phenotypic traits in Darwin's finches
Authors: Carrión Paola L. , Raeymaekers Joost A. M. , De León Luis Fernando , Chaves Jaime A. , Sharpe Diana M. T. , Huber Sarah K. , Herrel Anthony , Vanhooydonck Bieke , Gotanda Kiyoko M. , Koop Jennifer A. H. , Knutie Sarah A. , Clayton Dale H. , Podos Jeffrey , Hendry Andrew P. 
Published: October 2022

AbstractThe term terroir is used in viticulture to emphasize how the biotic and abiotic characteristics of a local site influence grape physiology and thus the properties of wine. In ecology and evolution, such terroir (i.e., the effect of space or “site”) is expected to play an important role in shaping phenotypic traits. Just how important is the pure spatial effect of terroir (e.g., differences between sites that persist across years) in comparison to temporal variation (e.g., differences between years that persist across sites), and the interaction between space and time (e.g., differences between sites change across years)? We answer this question by analyzing beak and body traits of 4388 medium ground finches (Geospiza fortis) collected across 10 years at three locations in Galápagos. Analyses of variance indicated that phenotypic variation was mostly explained by site for beak size (η2 = 0.42) and body size (η2 = 0.43), with a smaller contribution for beak shape (η2 = 0.05) and body shape (η2 = 0.12), but still higher compared to year and site‐by‐year effects. As such, the effect of terroir seems to be very strong in Darwin's finches, notwithstanding the oft‐emphasized interannual variation. However, these results changed dramatically when we excluded data from Daphne Major, indicating that the strong effect of terroir was mostly driven by that particular population. These phenotypic results were largely paralleled in analyses of environmental variables (rainfall and vegetation indices) expected to shape terroir in this system. These findings affirm the evolutionary importance of terroir, while also revealing its dependence on other factors, such as geographical isolation.
Regioselective Perfluoroalkylation of 4‐Quinolones Using Sodium Perfluoroalkyl Sulfinates
Authors: Dong Li , Wang Xiaoqing , Nie Yudi , Yu Shuo , Li Haotong , Zhao Qian , Fan Zixuan , Wang Yuqian , Tan Xiaoting , Yu Zhengsen 
Published: October 2022

AbstractA simple and metal‐free perfluoroalkylation of 4‐quinolones have been developed using sodium perfluoroalkyl sulfinates and ammonium peroxodisulfate in DMSO under mild conditions. This transformation provides direct access to C‐3 perfluoroalkylated 4‐quinolones with broad functionality in satisfactory yields. The control experimental results suggest a radical mechanistic pathway was involved in this protocol.
Understanding identity processes in support for reactionary and progressive social movements among advantaged and disadvantaged groups: The role of collective narcissism and secure ingroup identity
Authors: Marinthe Gaëlle , Cichocka Aleksandra , Cislak Aleksandra , Alexander‐Grose Natasha , Azevedo Flavio 
Published: October 2022

AbstractAcross five studies (two representative, one pre‐registered, total N = 4962), we examined the role of collective narcissism and secure identity in support for reactionary (Alt‐Right and nationalist) and progressive (Black Lives Matter and Women's Strike) social movements among advantaged (White Americans and Polish national majority) versus disadvantaged (Black Americans) groups. Among advantaged groups, collective narcissism, more so than secure identity, was related to more support for reactionary movements (Studies 1–4) and less support for progressive movements (Studies 1–3). Studies 3a, 3b and 4 directly compared members of advantaged and disadvantaged ethnic groups in the US and suggested that both collective narcissism and secure identity were positively associated with support for progressive movements among disadvantaged groups. This research contributes to understanding the identity processes involved in reactionary and progressive movements. It highlights the importance of distinguishing secure and defensive (i.e., narcissistic) identities, particularly when investigating support for reactionary movements among advantaged groups.