bluuebunny/crossref_metadata_2025_split huggingface dataset:
Das periokuläre Merkel-Zell-Karzinom – eine Übersicht klinischer Aspekte und aktueller Therapieoptionen
Authors: Esser Eliane , Grünewald Inga , Mihailovic Natasa 
Published: November 2022

ZusammenfassungDas Merkel-Zell-Karzinom (MCC) stellt einen seltenen, jedoch hochaggressiven und rasch expandierenden malignen Hauttumor dar. Die periokuläre Region ist in etwa 10% der Fälle betroffen. Die
aktuelle Therapieempfehlung des resektablen, nicht metastasierten MCC umfasst die chirurgische Totalexzision, allerdings sind bei Diagnosestellung bereits häufig Lymphknoten- oder
Fernmetastasen vorhanden. Seit der Erstzulassung einer Immun-Checkpoint-Inhibitor-Therapie mit Avelumab für das metastasierte MCC im Jahr 2016 hat sich das mittlere Überleben im Vergleich
zur zytostatischen Therapie erheblich gebessert bei gleichzeitig seltenerem Auftreten schwerwiegender therapieassoziierter unerwünschter Ereignisse. Weitere Immun-Checkpoint-Inhibitoren mit
ersten vielversprechenden Ergebnissen sind derzeit noch in der klinischen Erprobung. Eine interdisziplinäre Betreuung an einem spezialisierten Zentrum mit Vorstellung in einem Tumorboard ist
bei Patienten MCC aufgrund der komplexen Diagnostik, Therapie und Prognoseabschätzung essenziell.
Heilmittel und Superfood
Authors: Bös Dorothee 
Published: November 2022

SummaryVitalpilze wie Agaricus, Auricularia, Schopftintling, Raupenpilz, Hericium oder Reishi liefern nicht nur diätetisch wertvolle Proteine, sondern rund 200 bislang erforschte therapeutisch wirksame Inhaltsstoffe. In erster Linie handelt es sich bei Vitalpilzen um Adaptogene: Stärkungsmittel, die den Organismus wieder in eine gesunde Eigenregulation bringen können. Zu den Indikationen zählen die Senkung von erhöhtem Blutdruck, Cholesterin und Blutzucker sowie die Verbesserung von Mikrobiom, Darm- und Nervenfunktion, Frauenbeschwerden, Stoffwechsel, Durchblutung, Immunreaktion und Entzündungslage.
Unwissenheit schützt vor Strafe nicht
Authors: Pietruck Vivien 
Published: November 2022

SummaryWerbung im Internet kann zum Beispiel auf Social Media, der eigenen Website, einem Newsletter oder einem Blog erfolgen. Sollen Heilpraktikertätigkeiten online beworben werden, sind verschiedene Gesetze zu beachten, um insbesondere Abmahnungen zu vermeiden. Zur Rechtssicherheit von Onlinewerbung sollte ein entsprechender Fachanwalt zurate gezogen werden; wichtig ist ein rechtssicheres Grundgerüst.
Ein Ausflug ins Reich der Fadenwesen
Authors: Lüder Rita 
Published: November 2022

SummaryPilze zersetzen absterbende Blätter, Nadeln, Zweige und Stämme der Bäume und verwandeln diese zu Humus. Über das Fadennetzwerk im Boden versorgen die Pilze Pflanzen und dadurch indirekt auch Tiere mit Nährstoffen. In Mitteleuropa gibt es etwa 100 essbare Pilzarten und 150 giftige Arten und von diesen wiederum ca. 10 tödliche Arten. Der Geschmack kann täuschen: Die tödlich giftigen Arten schmecken weder scharf noch bitter. Bei Vergiftungen mit Pilzen ist häufig nicht der Verzehr von giftigen Arten, sondern die Zubereitung eigentlich essbarer Pilze ursächlich. Beispielsweise sollten aufgrund der sich schnell zersetzenden Eiweiße nur frische Pilze verzehrt werden. Eine ausreichende Garzeit ist ebenfalls wichtig.
Association of the CKM rs8111989 Polymorphism with Injury
Epidemiology in Football Players
Authors: Varillas-Delgado David , Morencos Esther , Gutierrez-Hellín Jorge , Aguilar-Navarro Millan , Maestro Antonio , Perucho Teresa , Coso Juan Del 
Published: November 2022

AbstractThe influence of the rs8111989 polymorphism in the muscle-specific creatine
kinase gene (CKM) on injury incidence is unknown. The aim was to
investigate CKM polymorphism on injury incidence in high-performance
football players. A cohort of 109 high-performance players was genotyped by
using saliva samples. Injury incidence was similar in players with the GG, GA,
and AA genotypes and did not modify incidence during training or match exposure
(p=0.583 and p=0.737 respectively). GG players had a higher
frequency of slight-severity injuries (60.0 vs. 10.2 vs. 24.2%,
p<0.001), while GA players had a higher frequency of severe injuries
(16.7 vs. 30.8 vs. 10.0%, p=0.021). GA players also had a higher
frequency of muscle tears (34.8 vs. 59.0 vs. 20.0%, p<0.001).
Muscle contracture was a more frequent injury in players with the GG genotype
(40.0%, p<0.001). G allele carriers had lower frequencies of
gradual-onset injuries (4.1 vs. 16.7%, p=0.035) and recurrent
injuries (6.1 vs. 16.7%, p=0.003) than AA players. A allele
carriers had higher frequency of severe injuries (10.0 vs. 21.9%,
p=0.044) than GG players. Genotypes in the CKM rs8111989
polymorphism did not affect injury incidence in high-performance football
players. Players with the GA genotype were more prone to severe injuries and
muscle tears when compared to GG and AA players.
Diabetische Neuropathie
Authors: Ziegler Dan , Keller Jutta , Maier Christoph , Pannek Jürgen 
Published: November 2022

ZUSAMMENFASSUNGDie diabetische Neuropathie ist eine klinisch manifeste oder subklinische Erkrankung der peripheren Nerven, die infolge eines Diabetes mellitus ohne andere Ursachen auftritt. Sie kann das somatische (diabetische sensomotorische Polyneuropathie, DSPN) und/oder das autonome Nervensystem (autonome diabetische Neuropathie, ADN) betreffen. Eine DSPN ist in 85–90 % an der Ätiologie des diabetischen Fußsyndroms beteiligt und hat damit einen erstrangigen Stellenwert in der Risikokonstellation für Fußulkus und Amputation. Wenn die auf Symptomen beruhende Verdachtsdiagnose einer diabetischen Neuropathie nicht durch die Basisuntersuchungen gesichert werden kann, sollen spezifische Untersuchungen (Elektroneurografie und vor allem bei Verdacht auf eine sog. Small-Fiber-Neuropathie eine Quantitative Sensorische Testung) durchgeführt werden. Eine frühzeitige Kontrolle der Stoffwechseleinstellung und bestehender Risikofaktoren (z. B. Rauchen, übermäßiger Alkoholkonsum, Bluthochdruck) kann die Progression einer diabetischen Neuropathie verhindern oder zumindest hinauszögern oder verlangsamen. Die Therapie der schmerzhaften diabetischen Polyneuropathie umfasst pharmakologische und nicht-pharmakologische Ansätze. Im Rahmen der analgetischen Pharmakotherapie sind wichtige Leitsätze zu beachten und individuelle Therapieziele anzustreben. Bei ADN lassen sich symptomatische Manifestationen von asymptomatischen nur durch Funktionstests unterscheiden. Grundsätzlich kann die ADN jedes autonom innervierte Organ betreffen, die Einteilung erfolgt entsprechend den betroffenen Organen und Funktionssystemen. Das stufenweise Vorgehen bei der Diagnostik entspricht grundsätzlich dem bei der sensomotorischen Neuropathie. Im Vordergrund stehen organspezifische Untersuchungen in Zusammenarbeit mit anderen Fachdisziplinen. Die Grundsätze der allgemeinen Behandlungsstrategien und Prävention bei der diabetischen sensomotorischen Neuropathie gelten gleichermaßen für die autonomen Neuropathien. Die symptomatische Pharmakotherapie an verschiedenen Organ- und Funktionssystemen ist in der Regel durch die entsprechenden Spezialisten im Rahmen der interdisziplinären Zusammenarbeit einzuleiten.
Hypertensive Schwangerschaftserkrankungen und
SARS-CoV-2/COVID-19: Auswertung des nationalen
CRONOS-Registers
Authors: Zöllkau Janine , Bohlmann Michael , Mingers Nina , Pecks Ulrich , Weschenfelder Friederike , Groten Tanja ,   Collaborating authors (in alphabetic order)
Published: November 2022

ZusammenfassungSARS-CoV-2-Infektion und COVID-19-Erkrankung sind in internationalen
Registerstudien mit einem erhöhten Risiko für hypertensive
Schwangerschaftserkrankungen assoziiert. Hypertensive Erkrankungen stellen zudem
einen Risikofaktor eines schweren COVID-19-Verlaufes in der Schwangerschaft dar.
Als pathophysiologische Gemeinsamkeit beider Erkrankungen wird die
Schädigung des Endothels angesehen.Daten des nationalen CRONOS-Registers (Datenstand 05/2021; 1104
schwangere Frauen mit SARS-CoV-2-Infektion) wurden hinsichtlich des
Zusammenhangs zu hypertensiven Schwangerschaftserkrankungen und dem Outcome von
Mutter, Schwangerschaft, Neugeborenen und COVID-19-Erkrankung analysiert. Bei
Vorliegen einer hypertensiven Schwangerschaftserkrankung war signifikant
häufiger ein schweres kombiniertes Outcome der Schwangerschaft (17,3 vs.
4,3%, p=0,001), der Mutter (25,0 vs. 9,4%,
p=0,001) und des Neugeborenen (28,8 vs. 9,1%, p<0,0005)
zu verzeichnen. Das Outcome der COVID-19-Erkrankung unterschied sich hingegen
nicht (3,8 vs. 7,5%, p=0,424). Hypertensive
Schwangerschaftserkrankungen sollten im Management einer SARS-CoV-2-Infektion in
der Schwangerschaft als Risikofaktor angesehen werden. Dies kann Implikationen
auf die Therapie haben, wie zum Beispiel mit monoklonalen Antikörpern
haben.
Discrepancies Between Osteoporotic Fracture Evaluations in Men Based
on German (DVO) Osteoporosis Guidelines or the FRAX Score
Authors: Witzel J C , Giessel A , Heppner C , Lamersdorf A , Leha A , Glüer C C , Siggelkow H 
Published: November 2022

Abstract
Introduction Established scores estimate 10-year fracture risk in
osteoporosis to assist with treatment recommendations. This study compared the
risk probabilities of major osteoporotic and hip fractures calculated by the
FRAX tool with those of the DVO score, established in German-speaking
countries.
Material and Methods This seven-year retrospective study analyzed data of
125 male patients (mean age: 59.2±10.7 years) evaluated for
osteoporosis. For the DVO score, the therapy threshold of>30%
for vertebral and hip fractures suggested by DVO guidelines was implemented. We
calculated fracture risks based on FRAX scores with aBMD and applied a common
therapy threshold of≥3% for hip fracture and subsequently
determined the “DVO-equivalent risk level” for FRAX-based
assessment that would identify as many male patients as identified by the DVO
score.
Results Based on DVO score, 60.0% of patients had a 10-year risk
of hip and vertebral fractures>30%. The recommendations for
individuals based on FRAX scores for hip fracture with aBMD with
risk≥3% overlapped with those based on DVO score in 36%
of patients. Patients identified for treatment only by DVO score presented a
higher percentage of spine fractures (65 vs. 41%). The thresholds for
this “DVO-equivalent risk level” for ‘FRAX with
aBMD’ was estimated to be≥6.7% for major osteoporotic
fracture and≥2.1% for hip fracture.This study demonstrates that the DVO score was more sensitive than the FRAX score
for patients with prevalent spinal fractures. We suggest considering the
appropriate score and therapy threshold carefully in the daily care of male
patients.
Three-Point Vertical Mattress Suture: A Simple Technique for Mild Blepharoptosis Correction in Partial-Incision Double-Eyelid Surgery
Authors: Chen Bo , Ma Li , Wang Jingyi 
Published: November 2022

AbstractThe aim of this study was to introduce a simple technique for mild blepharoptosis correction using a three-point vertical mattress suture in partial-incision double-eyelid surgery. The medical records and preoperative and postoperative images of 57 patients who underwent simultaneous mild blepharoptosis correction and partial-incision double-eyelid surgery from January 2018 to July 2021 were retrospectively reviewed. The surgical procedure mainly involves three small incisions in the proper eyelid crease, levator aponeurosis exposure by conservative dissection, and three-point vertical mattress suture to plicate levator aponeurosis and fix the orbicularis muscle with the plicated levator aponeurosis. All patients underwent bilateral partial-incision double-eyelid surgery: 10 unilateral and 47 bilateral blepharoptosis corrective surgeries. The average age was 25.3 ± 7.4 years. The mean operative and follow-up duration were 50 minutes and 13 months, respectively. The pre- and postoperative mean marginal reflex distance was 3.04 ± 0.27 and 3.75 ± 0.35 mm, respectively. The overall surgical success rate was 93%. Complications including undercorrection (5.3%), asymmetry (7.0%), and double-eyelid crease disappearance (5.3%) were reported. Three-point vertical mattress suture is considered an effective, safe, and simple technique for mild blepharoptosis correction in partial-incision double-eyelid surgery.
Hemostasis in Neonates with Perinatal Hypoxia—Laboratory Approach: A Systematic Review
Authors: Tsaousi Marina , Iliodromiti Zoi , Iacovidou Nicoletta , Karapati Eleni , Sulaj Alma , Tsantes Andreas G. , Petropoulou Chrysa , Boutsikou Theodora , Tsantes Argirios E. , Sokou Rozeta 
Published: November 2022

AbstractBirth asphyxia, with an estimated prevalence of 1 to 6 per 1,000 live births, may lead to multiorgan dysfunction due to impaired oxygen and/or blood supply to various organ systems, including the hemostatic system. Coagulopathy, a common complication of perinatal asphyxia, has been described since the 1960s. The aim of this study was to systematically review the literature for records on the use of hemostasis tests in the evaluation of coagulation disorders, in neonates who had suffered from perinatal hypoxia or asphyxia. We identified published studies by searching PubMed and Scopus, up until April 2022. The literature search retrieved 37 articles fulfilling the inclusion criteria of the review. According to the bibliography, thrombocytopenia is commonly associated with perinatal hypoxia/asphyxia. The thrombocytopenia is usually described as mild and platelets return to normal levels by the 10th day of life. Additionally, hypoxic neonates usually present with a hypocoagulable profile, as reflected by the prolongation of standard coagulation tests, including prothrombin time, activated partial thromboplastin time, and international normalized ratio, findings commonly associated with disseminated intravascular coagulation, and by the reduction of the levels of the physiologic inhibition of coagulation system. A few studies thus far using ROTEM/TEG in hypoxic neonates have come to the same conclusion as well; hypoxic newborns seem to be characterized by a hypocoagulable profile compared with healthy neonates. It should be emphasized, however, that standard coagulation tests provide only a rough estimation of the true bleeding or thrombotic risk of hypoxic neonates. On the contrary, viscoelastic methods seem to be more precise in the early detection of hemostasis disorders in the neonatal population. However, until now, there was uncertainty as to the most appropriate coagulation assays for diagnosis and management of coagulation derangement in neonates with perinatal hypoxia indicating the need for further research on this field.
Third Trimester Ultrasound Stratifies Risk of Peripartum Complications in Pregnancies Complicated by Impaired Glucose Tolerance
Authors: Crimmins Sarah , Martin Lucille , Solaru Opeyemi , Desai Andrea , Esteves Kristyn , Elsamadicy Emad , Kopelman Jerome N. , Turan Ozhan M. 
Published: November 2022

Objective The objective of our study was to investigate the effect of impaired glucose metabolism (IGM) and ultrasound (US) findings consistent with hyperglycemia on maternal and neonatal outcomes.
Study Design This was a retrospective case-control study of singleton, nonanomalous pregnancies with an elevated 1-hour glucose screening test (GST) completed after 23 weeks of gestation. IGM was defined as a 1-hour GST of >130, but less than two abnormal values on 3-hour glucose tolerance test (GTT). Gestational diabetes was defined as two or more abnormal values on 3-hour GTT. Ultrasound evidence of hyperglycemia was defined as abdominal circumference >95th centile and/or polyhydramnios. Individuals with IGM were divided into those with ultrasound evidence of hyperglycemia (impaired glucose metabolism consistent with ultrasound findings [IGM-US]) and those without IGM. Maternal demographics, delivery outcomes (gestational age at delivery, delivery mode, shoulder dystocia, lacerations), postpartum hemorrhage, and neonatal outcome (birth weight centile [BW%], neonatal intensive care unit admission, hypoglycemia, and glucose) were recorded. Composite morbidity was tabulated. Delivery and neonatal outcome variables were compared in individuals with IGM-US, IGM, and gestational diabetes mellitus (GDM). Odds ratios were calculated and adjusted for maternal age, BMI, and gestational weight gain.
Results A total of 637 individuals with an abnormal 1-hour GST were included (122 with IGM-US, 280 with IGM, and 235 with GDM). When compared to the IGM group, IGM-US had higher rates of cesarean delivery and BW% > 90th centile at delivery (adjusted odds ratio [aOR]: 1.7 [1.1–2.8] and aOR: 5.9 [2.7–13.0], respectively). Individuals with GDM also demonstrated similar rates with BW% > 90% but not cesarean section(aOR: 3.9 [1.8–8.5] and aOR: 1.4 [0.9–2.1], respectively). The remaining maternal and fetal outcomes were similar.
Conclusion Women with impaired glucose tolerance should have a third-trimester ultrasound to identify an increased risk of perinatal complications.
Key Points
Evolution of non-fatal burden estimates for cardiovascular disease in Australia: a comparison of national and state-wide methodology of burden of disease
Authors: Weber Courtney , Hobday Michelle , Sun Wendy , Kirkland Laura , Nedkoff Lee , Katzenellenbogen Judith M. 
Published: November 2022

Objective Burden of disease studies measure the impact of disease at the population level;however, methods and data sources for estimates of prevalence vary. Using a selection of cardiovascular diseases, we aimed to describe the implications of using different disease models and linked administrative data on prevalence estimation within three Australian burden of disease studies. Methods Three different methods (A = 2011 Australian Burden of Disease Study; B = 2015 Australian Burden of Disease Study; C = 2015 Western Australian Burden of Disease Study), which used linked data, were used to compare prevalence estimates of stroke, aortic aneurysm, rheumatic valvular heart disease (VHD) and non-rheumatic VHD. We applied these methods to 2015 Western Australian data, and calculated crude overall and age-specific prevalence for each condition. Results Overall, Method C produced estimates of cardiovascular prevalence that were lower than the other methods, excluding non-rheumatic VHD. Prevalence of acute and chronic stroke was up to one-third higher in Method A and B compared to Method C. Aortic aneurysms had the largest change in prevalence, with Method A producing an eight-fold higher estimate compared to Method C, but Method B was 10–20% lower. Estimates of VHD varied dramatically, with an up to six-fold change in prevalence in Method C due to substantial changes to disease models and the use of linked data. Conclusions Prevalence estimates require the best available data sources, updated disease models and constant review to inform government policy and health reform. Availability of nation-wide linked data will markedly improve future burden estimates.
Surface roughness – the key for roll bonding aluminium
Authors: Biradar Akash , Rijesh M. 
Published: November 2022

In this study, the commercially pure aluminium is roll bonded at ambient temperatures. The effect of surface roughness and roll speed on the bond strength is evaluated by using the lap shear test. It is observed that the bond strength increased considerably with increasing surface roughness. The deformation caused owing to scratch brushing changed the surface roughness profile, which is the salient reason for the bond strength variation. Continuous striations with peaks and valleys of small-scale heights are observed at lower roughness values. Increasing roughness has reformed them into discrete profile asperities with sharp tips, influencing localised junction formation. On the other hand, the roll velocity has shown hardly any effect on the roll bonding of aluminium. With thorough investigation, it was conclusively explained that the effective change in the bond strength was not appreciable with varying the roll speed, provided the roll bonding takes place at optimised surface roughness conditions.
Surface quality optimization of laser cladding based on surface response and genetic neural network model
Authors: Zhang Yuhang , Xu Yifei , Sun Yaoning , Cheng Wangjun 
Published: November 2022

Abstract
The model was established to optimize the laser cladding process parameters, the coating surface topography can be predicted and controlled. Taguchi and Box-Behnken (BBD) experiments were used to carry out the experimental design of laser cladding multi-channel lap. 316 L stainless steel coating was cladded on the surface of 45 steel substrate. The genetic algorithm-back propagation (GA-BP) neural network and response surface methodology (RSM) models were established respectively. The prediction accuracy of the two models was compared. The coupling effect between cladding process and multi-channel lap forming quality was analyzed. The relationship between cladding process parameters, such as laser power, feeding speed, scanning speed and overlap ratio, and surface roughness of coating was studied. The experimental results show that: The root mean square error (RMSE) and absolute mean deviation (AAD) of the GA-BP model are smaller than those of the RSM model. The coefficient of determination R2 of the GA-BP model is closer to 1 than that of the RSM model. The minimum roughness predicted by GA-BP model is 20.89 μm, which is lower than that of RSM model (35.67 μm). The final findings: in the optimization of process parameters of laser cladding, overlap ratio and scanning speed has significant effects on coating surface roughness. The GA-BP model of the coating surface roughness prediction accuracy is better than the RSM model. The prediction and control of the coating surface roughness are realized by GA-BP model, for the precise forming of the laser cladding coating surface, which provides theoretical basis and technological direction.
RaMP-DB 2.0: a renovated knowledgebase for deriving biological and chemical insight from metabolites, proteins, and genes
Authors: Braisted John , Patt Andrew , Tindall Cole , Sheils Timothy , Neyra Jorge , Spencer Kyle , Eicher Tara , Mathé Ewy A 
Published: November 2022

AbstractMotivationFunctional interpretation of high-throughput metabolomic and transcriptomic results is a crucial step in generating insight from experimental data. However, pathway and functional information for genes and metabolites are distributed among many siloed resources, limiting the scope of analyses that rely on a single knowledge source.ResultsRaMP-DB 2.0 is a web interface, relational database, API and R package designed for straightforward and comprehensive functional interpretation of metabolomic and multi-omic data. RaMP-DB 2.0 has been upgraded with an expanded breadth and depth of functional and chemical annotations (ClassyFire, LIPID MAPS, SMILES, InChIs, etc.), with new data types related to metabolites and lipids incorporated. To streamline entity resolution across multiple source databases, we have implemented a new semi-automated process, thereby lessening the burden of harmonization and supporting more frequent updates. The associated RaMP-DB 2.0 R package now supports queries on pathways, common reactions (e.g. metabolite-enzyme relationship), chemical functional ontologies, chemical classes and chemical structures, as well as enrichment analyses on pathways (multi-omic) and chemical classes. Lastly, the RaMP-DB web interface has been completely redesigned using the Angular framework.Availability and implementationThe code used to build all components of RaMP-DB 2.0 are freely available on GitHub at https://github.com/ncats/ramp-db, https://github.com/ncats/RaMP-Client/ and https://github.com/ncats/RaMP-Backend. The RaMP-DB web application can be accessed at https://rampdb.nih.gov/.Supplementary informationSupplementary data are available at Bioinformatics online.