bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorite‐Structured Ferroelectric and Antiferroelectric Materials: A Gateway of Miniaturized Electronic Devices
Authors: Ali Faizan , Ali Tarek , Lehninger David , Sünbül Ayse , Viegas Alison , Sachdeva Ridham , Abbas Akmal , Czernohorsky Malte , Seidel Konrad 
Published: April 2022

AbstractFerroelectric (FE) and antiferroelectric (AFE) materials are used for several memory‐related and energy‐related applications. Perovskite materials (e.g., bulk ceramics) remain the most common materials for many applications. However, due to large deposition thickness, these materials are not appropriate for future miniaturized devices. In 2011, FE and AFE properties were reported in Si‐doped HfO2 thin films. HfO2‐based FE and AFE materials have several advantages over conventional materials, such as ultrathin deposition thickness (in range of nanometers), compatibility with existing Si semiconductor technology, and suitability for the integration within 3‐D nanostructures. Therefore, fluorite‐structured materials can be appropriate for miniaturized devices. These fluorite‐structured materials are extensively studied for memory and energy‐related applications. The first review on this topic was published after four years of discovering the FE and AFE properties in these materials. From the past decade, a lot of research has been reported about the detailed mechanism and application of these materials. This review insightfully discusses the progress in the research of fluorite‐structured materials and critically discusses some potential applications. Here some challenges are also discussed, new knowledge is extracted, and promising future research directions of these materials are suggested.
Curved Photodetectors Based on Perovskite Microwire Arrays via In Situ Conformal Nanoimprinting
Authors: Li Shun‐Xin , Xia Hong , Sun Xiang‐Chao , An Yang , Zhu He , Sun Hong‐Bo 
Published: April 2022

AbstractMicro/nano optoelectronic devices based on curved substrates play a significant role in the development of wearable devices, electronic skin, conformal sensors, conformal antennas, and soft robots. However, the current fabrication processes are oriented toward planar micro/nano devices, and the fabrication of such devices on curved substrates is challenging. Herein, a temperature‐gradient‐assisted nanoimprint‐based in situ micro/nano‐crystal growth method is proposed to fabricate high‐quality curved perovskite microwire crystal (MWC) arrays on curved surfaces. Based on this curved perovskite MWC array without bending‐induced defects, high‐performance curved photodetectors (responsivity = 414 A W−1, detectivity = 1.2 × 1014 Jones, and external quantum efficiency over 140 000%) with extraordinary stability (85% of original performance maintained for more than 2 years) are fabricated to realize a curved imaging device. These results provide insights into the application of high‐performance perovskite photodetectors in nonconformal optical systems.
Noninvasive and Individual‐Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing
Authors: Zhang Yaping , Yu Huijuan , Chai Shiwei , Chai Xin , Wang Luyao , Geng Wen‐Chao , Li Juan‐Juan , Yue Yu‐Xin , Guo Dong‐Sheng , Wang Yuefei 
Published: April 2022

AbstractCharacterized by an excessively increased uric acid (UA) level in serum, hyperuricemia induces gout and also poses a great threat to renal and cardiovascular systems. It is urgent and meaningful to perform early warning by noninvasive diagnosis, thus conducing to blockage of disease aggravation. Here, guanidinocalix[5]arene (GC5A) is successfully identified from the self‐built macrocyclic library to specifically monitor UA from urine by the indicator displacement assay. UA is strongly bound to GC5A at micromolar‐level, while simultaneously excluding fluorescein (Fl) from the GC5A·Fl complex in the “switch‐on” mode. This method successfully differentiates patients with hyperuricemia from volunteers except for those with kidney dysfunction and targets a volunteer at high risk of hyperuricemia. In order to meet the trend from hospital‐centered to individual‐centered testing, visual detection of UA is studied through a smartphone equipped with a color‐scanning feature, whose adaptability and feasibility are demonstrated in sensing UA from authentic urine, leading to a promising method in family‐centered healthcare style. A high‐throughput and visual detection method is provided here for alarming hyperuricemic by noninvasive diagnosis.
Single‐cell RNA Sequencing Identified Novel Nr4a1+ Ear2+ Anti‐Inflammatory Macrophage Phenotype under Myeloid‐TLR4 Dependent Regulation in Anti‐Glomerular Basement Membrane (GBM) Crescentic Glomerulonephritis (cGN)
Authors: Chen Jiaoyi , Huang Xiao Ru , Yang Fuye , Yiu Wai Han , Yu Xueqing , Tang Sydney C. W. , Lan Hui Yao 
Published: April 2022

AbstractPreviously, this study demonstrates the critical role of myeloid specific TLR4 in macrophage‐mediated progressive renal injury in anti‐glomerular basement membrane (anti‐GBM) crescentic glomerulonephritis (cGN); however, the underlying mechanism remains largely unknown. In this study, single‐cell RNA sequencing (scRNA‐seq), pseudotime trajectories reconstruction, and motif enrichment analysis are used, and macrophage diversity in anti‐GBM cGN under tight regulation of myeloid‐TLR4 is uncovered. Most significantly, a myeloid‐TLR4 deletion‐induced novel reparative macrophage phenotype (Nr4a1+Ear2+) with significant upregulated anti‐inflammatory and tissue repair‐related signaling is discovered, thereby suppressing the M1 proinflammatory responses in anti‐GBM cGN. This is further demonstrated in vitro that deletion of TLR4 from bone marrow‐derived macrophages (BMDMs) induces the Nr4a1/Ear2‐expressing anti‐inflammatory macrophages while blocking LPS‐stimulated M1 proinflammatory responses. Mechanistically, activation of the Nr4a1/Ear2‐axis is recognized as a key mechanism through which deletion of myeloid‐TLR4 promotes the anti‐inflammatory macrophage differentiation in vivo and in vitro. This is confirmed by specifically silencing macrophage Nr4a1 or Ear2 to reverse the anti‐inflammatory effects on TLR4 deficient BMDMs upon LPS stimulation. In conclusion, the findings decode a previously unidentified role for a myeloid‐TLR4 dependent Nr4a1/Ear2 negative feedback mechanism in macrophage‐mediated progressive renal injury, implying that activation of Nr4a1‐Ear2 axis can be a novel and effective immunotherapy for anti‐GBM cGN.
Do zoo‐housed primates retreat from crowds? A simple study of five primate species
Authors: Cairo‐Evans Alexandria , Wierzal Natasha K. , Wark Jason D. , Cronin Katherine A. 
Published: April 2022

AbstractAn animal's welfare state is directly influenced by the mental state, which is shaped by experiences within the environment throughout the animal's life. For zoo‐housed animals, visitors to the zoo are a large part of that environment and a fluctuating influence within it. This study examines the impact of zoo visitors on the space use of five species of zoo‐housed primates (Eastern black‐and‐white colobus monkeys, Colobus guereza, n = 5, Allen's swamp monkeys, Allenopithecus nigroviridis, n = 2, DeBrazza's monkeys, Cercopithecus neglectus, n = 3, Bolivian gray titi monkeys, Callicebus donacophilus, n = 3, and crowned lemurs, Eulemur coronatus, n = 3). Specifically, we considered whether primates' distance from visitor areas changed as crowd sizes increased. Data were collected using the ZooMonitor app. Observers recorded spatial coordinates for each animal over periods ranging from 12 to 32 months. Data were analyzed using two types of regression models (linear and logistic) to examine the influence of visitors on the location of the primates. Both analyses revealed a statistically significant but small decrease in primate distance from visitor viewing glass as the number of visitors increased. Behavioral indicators of welfare were also unaffected by the presence of visitors. These results suggest that, with additional validation, distance from visitors may be one promising, simple way to evaluate the influence of visitors on primate welfare.
The reinforcing effect of cyclic binary secondary amine chain extenders on the cryogenic performance of thermoplastic polyurethane elastomers
Authors: Geng Yanfei , Wang Meng , Li Wenke , Yi Pengcheng , Ji Yumei , Stewart Callum , Yang Yike , Liu Feng 
Published: April 2022

AbstractThe poor cryogenic performance of thermoplastic polyurethanes (TPU) severely restricts their extensive application in low‐temperature fields as elastomers. Chain extenders are one of the adjustable items for TPUs to optimize cryogenic performance. In this contribution, three cyclic amine homologs of imidazoline, piperazine and 2‐methylpiperazine are selected as bi‐functional chain extenders. The corresponding TPU elastomers, TPU‐IM, TPU‐PP, and TPU‐2P with identical soft segments, are synthesized by the prepolymer method. All TPUs' structure, morphology and thermodynamic properties were investigated. The results showed that the cyclic amine structure embedded in TPU hard segment can effectively promote microphase separation through hydrogen‐bonded crosslink and polar aggregation on the molecular scale, achieving a glass transition temperature (Tg) as low as −103.9°C for resisting low temperatures. The mechanical properties also demonstrated a 23‐fold improvement compared to the control TPU‐BD. The elastomer TPU‐PP possessed the best all‐around performance with an ideal Tg of −98.4°C and tensile strength of 18.1 MPa. We believe that these TPUs will have potential applications in cryogenic engineering.
The current scenario on anticancer activity of artemisinin metal complexes, hybrids, and dimers
Authors: Zhang Shu , Yi Chuan , Li Wei‐Wei , Luo Yang , Wu Yi‐Zhe , Ling Hai‐Bo 
Published: April 2022

AbstractCancer, the most significant cause of morbidity and mortality, has already posed a heavy burden on health care systems globally. In recent years, cancer treatment has made a significant breakthrough, but cancer cells inevitably acquire resistance, and the efficacy of the treatment is greatly reduced as the tumor progresses. To overcome the above issues, novel chemotherapeutics are needed urgently. Artemisinin and its derivatives—sesquiterpene lactone compounds possessing a unique peroxy bridge moiety—exhibit excellent safety and tolerability profiles. Mechanistically, artemisinin derivatives can promote cancer cell apoptosis, induce cell cycle arrest and autophagy, and inhibit cancer cell invasion and migration. Accordingly, artemisinin derivatives demonstrate promising anticancer efficacy both in vitro and in vivo, and even in clinical Phase I/II trials. The purpose of the present review article is to provide an emphasis on the current scenario (January 2017–January 2022) of artemisinin derivatives with potential anticancer activity, inclusive of artemisinin metal complexes, hybrids, and dimers. The structure–activity relationships and mechanisms of action are also discussed to facilitate the further rational design of more effective candidates.
How incumbents realize disruptive circular innovation ‐ Overcoming the innovator's dilemma for a circular economy
Authors: Kuhlmann Marianne , Bening Catharina R. , Hoffmann Volker H. 
Published: April 2022

AbstractDespite the promises of the circular economy to become an attractive source of innovation, many firms have so far hesitated to pursue circular innovations. Incumbents are facing a dilemma: While circular innovations may be potentially disruptive to the current profitable linear business, standing still may be dangerous, as traditional businesses may be rendered obsolete in the current changing environment. Yet, the literature has so far provided only a few insights into how firms can approach circular innovations strategically. By using the lens of disruptive innovation, we offer a strategic analysis of circular innovation challenges and potential ways to overcome them. Based on two in‐depth cases, we show how a separate organizational structure can help to implement potentially disruptive circular innovation, but some caveats exist. In addition, this structural separation should be linked with a clear innovation strategy, and the partnerships, organizational culture, and competencies needed for implementation should also be considered.
A comprehensive study of the abdominal ganglia part 1: Celiac, phrenic and superior mesenteric ganglia
Authors: du Plessis Maira , Loukas Marios 
Published: April 2022

AbstractIntroductionPatients with pancreatic cancer, chronic pancreatitis and other abdominal pain syndromes may develop debilitating pain throughout the course of their illness with little to no relief by most conventional methods. While some form of relief is experienced by patients, not all benefit from these procedures and side effects, while transitory in most cases are severe and often not expected. Our aim was therefore to investigate the anatomy surrounding the abdominal sympathetic ganglia, the target for the invasive procedures in an attempt to understand the variations in results.Materials and methodsThe abdominal cavities of nine individuals were dissected and the ganglia investigated, harvested and histologically and immunochemical stained.ResultsThe phrenic ganglion was found inconsistently and more often in the left than the right. If present it was located in association with the inferior phrenic artery and often connected to the celiac ganglion. The celiac ganglion was located anterior to the diaphragmatic crus on both sides and specifically posteromedial to the suprarenal gland and superior to the renal artery on the left. On the right it was located posterior to the suprarenal gland and inferior vena cava also superior to the renal vessels. The superior mesenteric ganglion was only positively identified in one individual and was located on the left lateral aspect of the superior mesenteric artery.ConclusionThe blockade procedures for treatment of pain are developed to target the area around the celiac artery where the ganglion is commonly described to be located. However, based on our results of its location and interconnections the ganglion is not located in the targeted area.
Compared with fresh injera, stale injera increases satiety in healthy subjects, but does not decrease the glycemic index
Authors: Yaregal Zemenu , Baye Kaleab , Fardet Anthony 
Published: April 2022

AbstractBackground and ObjectivesThe impact of food structure on postprandial physiological responses has received sustained attention in recent years. Changes in the glycemic response and satiety score to commonly consumed starchy foods may have a positive impact on health. However, no data on Ethiopian staple foods has been reported. This study aimed at investigating the effects of structural changes in injera (stale and fresh with similar macronutrient content) on glycemic and satiety responses in 10 healthy subjects during 2 h in a randomized cross‐over design.FindingsWith increasing hardness, stale injera had a marked higher satiety index (iAUC = 407 ± 14; p = .001) than fresh injera (iAUC = 333 ± 18). Besides, stale injera had a slightly, but not significant, lower glycemic index (GI) than fresh injera (stale, 35.9 ± 3.6; fresh, 40.2 ± 3.0).ConclusionsInjera staling increased satiety but not glycemic response, and may provide a simple means for improving its health potential.Significance and NoveltyThe effect of injera staling on satiety/glycemic responses has never been studied before. Injera is a staple food in Ethiopia, eaten several times a day. Therefore, stale injera may help reducing food intake of subsequent unhealthy foods through increased satiety.
A novel design of 3D carbon host for stable lithium metal anode
Authors: Liu Hang , Di Jie , Wang Ping , Gao Rui , Tian Han , Ren Pengfei , Yuan Qingxi , Huang Wanxia , Liu Ruiping , Liu Qiang , Feng Ming 
Published: April 2022

AbstractRational design of porous conductive hosts with high electrical conductivity, large surface area, and adequate interior space is desirable to suppressing dendritic lithium growth and accommodating large volume change of lithium metal anode during the Li plating/stripping process. However, due to the conductive nature of the conductive hosts, Li is easily deposited directly on the top of the hosts, which hinders it from fully functioning. To circumvent the issue, in this study, we designed a novel porous carbon host with a gradient‐pore‐size structure based on one‐dimensional (1D) carbon with different diameters. With this kind of host, stable cycling with high and stable Coulombic efficiency of ~98% is achieved at 0.5 mA cm−2 with an areal capacity of 1 mAh cm−2 over 320 cycles. In contrast, the normal three‐dimensional (3D) carbon nanotube host presents a moss‐like Li morphology with wildly fluctuating Coulombic efficiency after 100 cycles. The results reveal that the unique gradient‐pore‐size structure of the 3D conductive host greatly improves the performance of lithium metal batteries.
Two‐in‐one shell configuration for bimetal selenides toward fast sodium storage within broadened voltage windows
Authors: Yan Zichao , Zhao Lingfei , Liang Yaru , Zhang Lei , Liu Hanwen , Zhu Zhiqiang , Wang Yunxiao , Chou Shu‐Lei 
Published: April 2022

AbstractThe shell structure design has been recognized as a highly efficient strategy to buffer the severe volume expansion and consecutive pulverization of conversion‐type anodes. Nevertheless, construction of a functional shell with a stabilized structure that meets the demands of both high electronic conductivity and feasible pathways for Na+ ions has been a challenge so far. Herein, we design a two‐in‐one shell configuration for bimetal selenides to achieve fast sodium storage within broadened voltage windows. The hybridized shell, which benefits from the combination of titanium dioxide quantum dots and amorphous carbon, can not only effectively buffer the strain and maintain structural integrity but also allow facile and reversible transport of electrons and Na+ uptake for electrode materials during sodiation/desodiation processes, resulting in increased reaction kinetics and diffusion of sodium ions, conferring many benefits to the functionality of conversion‐type electrode materials. As a representative material, Ni‐CoSe2 with such structural engineering shows a reversible capacity of 515 mAh g−1 at 0.1 A g−1 and a stable capacity of 416 mAh g−1 even at 6.4 A g−1; more than 80% of the capacity at 0.1 A g−1 could be preserved, so that this strategy holds great promise for designing fast‐charging conversion‐type anodes in the future.
Construction and Activity of an All‐Organic Heterojunction Photocatalyst Based on Melem and Pyromellitic Dianhydride
Authors: Li Yuxin , Jiang Zeyu , Dong Guohui , Ho Wingkei 
Published: April 2022

AbstractThe separation efficiency of photogenerated carriers in the g‐C3N4system could be improved by the construction of all‐organic heterojunctions. However, g‐C3N4has a large π–π conjugated plane that induces a low number of amino groups (−NH2), which are the sites of the heterojunction reaction with organic molecules. In this case, few heterojunction knots can be constructed, and the enhancement effect of the heterojunction cannot be fully displayed. In this study, an all‐organic heterojunction with PMDA is constructed with melem instead of g‐C3N4. Although the photocatalytic activity of melem is far below that of g‐C3N4, the photocatalytic activity of PI (the all‐organic heterojunction constructed with melem) is considerably higher than that of CP (the all‐organic heterojunction constructed with g‐C3N4). This result is attributed to melem that has more –NH2groups to form more heterojunction knots, which can enable the effective transfer and separation of electron‐hole pairs. These new findings may shed light on the design of all‐organic heterojunction photocatalysts.
Associations between peer stress in early adolescence and multiple event‐related potentials elicited during social feedback processing
Authors: Panier Lidia , Ethridge Paige , Farrell‐Reeves Alison , Punturieri Claire , Kujawa Autumn , Dirks Melanie , Weinberg Anna 
Published: April 2022

AbstractInterpersonal stress in adolescence has been associated with alterations in neural responses to peer feedback, and increased vulnerability to psychopathology. However, it is unclear whether the associations of interpersonal problems with neural responses are global across event‐related potentials (ERPs) or might result in alterations only in specific ERPs. We examined associations between multiple informants of peer stress (self‐reported, parent‐reported, and peer‐reported) and multiple ERPs (N1, P2, RewP, and LPP) to social feedback in a sample of 46 early adolescents (aged 12–13 years). Reports of peer stress were only moderately correlated with one another, indicating different informants capture different aspects of peer stress. Regressions using informant reports to predict ERPs revealed greater parent‐reported peer stress was associated with a smaller RewP, whereas self‐reported stress was associated with a smaller P2, to acceptance. In contrast, greater peer‐reported stress was associated withlargerP2, RewP, and LPP to acceptance. Findings suggest that different sources of stress measurement are differentially associated with ERPs. Future research using social feedback‐related ERPs should consider multiple sources of information as well as multiple ERP components across the time‐course of feedback processing, to gain a clearer understanding of the effects of peer stress on neural responses to feedback.
Conservative surgical treatment for metatarsal osteomyelitis in diabetic foot: experience of two French centres
Authors: Nguyen Sophie , Wallard Pauline , Robineau Olivier , Topolinski Hélène , Beltrand Eric , Benkanoun Ali , Baranski Didier , Descamps Dominique , Senneville Eric 
Published: April 2022

AbstractAimsConservative surgery (CS) for diabetic foot osteomyelitis (DFO) consists in removing all or part of the infected bone tissues without amputation, in complement with antibiotic therapy. Data on CS for DFO therapy are scarce.Material and MethodsWe performed a retrospective analysis of all DFO episodes treated with CS between 06/2007 and 12/2017. Remission was defined by the absence of soft‐tissue infection, complete sustained (i.e. > 1 month) healing of the foot ulcer, favourable (i.e., stabilisation or improvement) radiological outcome, and no need for additional surgery during a 1‐year follow‐up.ResultsDuring the study period, 47 episodes (in 41 patients) were analysed. Excluding deaths (all unrelated to the DFO;n = 3) or loss to follow‐up before 1 year (n = 5), the remission rate was 64.2%. Most failures occurred during the first 6 months (79%, 11/14). Patients who experienced failure had a higher rate of peripheral arterial disease with arterial stenosis than patients in remission (57% vs. 24%,P = 0.03), a higher C‐reactive protein rate at admission (116 ± 112 mg/L vs. 48 ± 46 mg/L,P = 0.02), and a trend for a higher rate of abscesses (29% vs. 4%,P = 0.06). At 1‐year follow‐up, foot ulcers related to transfer lesion were identified in 25.5% of the cases. At the last follow‐up (mean 3 ± 2 years), the remission rate was 23/25 (92%).ConclusionsOur results suggest that CS is a therapeutic option in patients with localised but severe DFO. Clinicians should, however, consider the necessity of revascularisation, and higher risk of failure if surgery is performed in patients presenting with acute foot infections.