bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expanding the limits of nuclear stability: Drip lines for hot nuclei
Authors: Ravlić Ante , Yuksel Esra , Nikšić Tamara , Paar Nils 
Published: December 2022

Abstract
Nuclear processes in stellar environment occur at finite temperature, e.g., of the order of 106 kelvin in our Sun, up to 109 kelvin or even higher in core-collapse supernovae and neutron star mergers. The properties of hot nuclei are different than what we know from most of the experimental and theoretical studies, mainly limited to zero temperature. In a simplified picture, hot nucleus is surrounded by a vapor of emitted nucleons, which provides both chemical and mechanical equilibrium. Since it is unknown how many protons and neutrons can be bound together in hot nuclei, it is necessary to determine the limits of nuclear existence (drip lines) at finite temperature. Here we report the first mapping of drip lines for hot nuclei at temperatures up to T = 0 - 2.3×1010 kelvin (0 - 2 MeV), using the relativistic density functional theory supplemented with the particle continuum subtraction method. Surprizing discovery shows that the total number of bound nuclei is larger at high temperatures compared to cold nuclei, due to the thermal quenching of the shell effects. The increase in number of metastable hot nuclei is especially pronounced above N=82, N = 126 and N = 184 shell closures. Potentially, accounting for the properties of hot nuclei could have significant implications for the nuclear processes in astrophysical environments such as supernovae and neutron star mergers.
A multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastoma
Authors: Shojaei Shahla , Basso João , Amereh Meitham , Alizadeh Javad , Dehesh Tania , Rosa Simone da Silva , Clark Courtney , Hasan Misha , Tomczyk Mateusz , Cole Laura , Hatch Grant , Dolinsky Vernon , Pascoe Christopher , Schibli David , Dhingra Sanjiv , Srivast Abhay , Ravandi Amir , Vitorino Rui , Khademhosseini Ali , Ghavami Saeid , Akbari Mohsen 
Published: December 2022

Abstract
Chemoresistance is a major clinical challenge in management of glioblastoma (GBM). Temozolomide (TMZ) is the chemotherapeutic drug of choice for GBM; however, the therapeutic effect of TMZ is limited due to the development of resistance. Recapitulating GBM chemoresistance in a controlled environment is thus essential in understanding the mechanism of chemoresistance. Herein, we present a hybrid microphysiological model of chemoresistant GBM-on-a-chip (HGoC) by directly co-culturing TMZ-resistant GBM spheroids with healthy neurons to mimic the microenvironment of both the tumor and the surrounding healthy tissue. We characterized the model with proteomics, lipidomics, and secretome assays. The results showed that our artificial model recapitulated the molecular signatures of recurrent GBM in humans. Both showed alterations in vesicular transport and cholesterol pathways, mitotic quiescence, and a switch in metabolism to oxidative phosphorylation associated with a transition from mesenchymal to amoeboid. This is the first report to unravel the interplay of all these molecular changes as a mechanism of chemoresistance in glioblastoma. Moreover, we have shown that acquisition of resistance increases invasiveness and the presence of neurons decreases this property.
Temperature Effect on Coagulation Function in Mild Hypothermic Patients Undergoing Thoracic Surgeries: Thromboelastography (TEG) versus Standard Tests
Authors: Hui Shangyi , Zhang Qian , Lang Jiaxin , Yi Jie 
Published: December 2022

Abstract

Purpose
Our previous research has revealed that mild hypothermia leads to excessive bleeding in thoracic surgeries, while the underlying mechanism stayed unrevealed by the standard coagulation tests. The research question in this study was: “How does mild hypothermia impair the hemostatic function in patients receiving thoracic surgeries?”. The purpose was to detect the disturbed coagulation processes by comparing the TEG parameters in patients receiving active vs. passive warming during thoracic surgeries.
Methods
Standard coagulation tests and thromboelastography (TEG) were adopted to compare the hemostatic functions in patients receiving active vs. passive warming during thoracic surgeries. Furthermore, blood samples from passive warming group were retested for TEG at actual core body temperatures.
Results
Sixty-four eligible patients were included in this study. TEG revealed that mild hypothermia significantly disturbed coagulation by decreasing MA (59.4 ± 4.5mm vs. 64.2 ± 5.7mm, p = 0.04) and α angle (70.4 ± 5.2° vs. 74.9 ± 4.4°, p = 0.05), and prolonging ACT(122.2 ± 19.3s vs. 117.3 ± 15.2s, p = 0.01) and K time(1.9 ± 1.0s vs. 1.3 ± 0.4min, p = 0.02). TEGs conducted under core body temperatures revealed more impaired coagulation than those incubated at 37℃. Furthermore, postoperative shivering and waking time were significantly increased in mild hypothermic patients.
Conclusion
Mild hypothermia significantly impaired coagulation function in patients receiving thoracic surgeries, which could be detected by TEGs other than the standard coagulation tests. Temperature-adjusted TEGs may provide a preferable method of hemostatic monitoring and transfusion guidance in thoracic surgeries, which warrants further clinical investigations.
Establishment and evaluation of nomogram for predicting intraventricular hemorrhage in neonatal acute respiratory distress syndrome
Authors: Arkin Nurbiya , Wang Yanmei , Wang Le 
Published: December 2022

Abstract
Background: Intraventricular hemorrhage（IVH）is the most common type of brain injury in newborns, especially in newborns with ARDS. IVH can cause brain parenchyma damage and long-term neurological sequelae in children. Early identification and prevention of sequelae are essential. This study aims to establish a predictive nomogram for the early prediction of IVH in newborns with ARDS.
Methods: From 2019 to 2021, we collected data from 222 infants diagnosed with ARDS in the Department of Neonatology, First Affiliated Hospital of Xinjiang Medical University. Infants have been randomly assigned to the training set (n=161) or the validation set(n=61) at a ratio of 7:3. Variables were screened using the Least Absolute Contract and Selection Operator (LASSO) regression to create a risk model for IVH in infants with ARDS. The variables chosen in the LASSO regression model were used to establish the prediction model using multivariate logistic regression analysis.
Results: We recognized 4 variables as independent risk factors for IVH in newborns with ARDS via LASSO analysis, consisting of premature rupture of membranes (PROM), pulmonary surfactant (PS) dosage, PH1 and O21. The C-Index for this dataset is 0.868 (95% CI: 0.837-0.940) and the C index in bootstrap verification is 0.852 respectively. The analysis of the decision curve shows that the model can significantly improve clinical efficiency in predicting IVH. We also provide a website based on the model and open it to users for free, so that the model can be better applied to clinical practice.
Conclusions: In conclusion, the nomogram based on 4 factors shows good identification, calibration and clinical practicability. Our nomographs can help clinicians make clinical decisions, screen high-risk ARDS newborns, and facilitate early identification and management of IVH patients.
Tapered Whisker Reservoir Computing for Real-time Terrain Identification-Based Navigation
Authors: Yu Zhenhua , Sadati S. M. Hadi , Perera Shehara , Hauser Helmut , Childs Peter R.N. , Nanayakkara Thrishantha 
Published: December 2022

Abstract
This paper proposes a new method for real-time terrain recognition-based navigation for mobile robots. Mobile robots performing tasks in unstructured environments need to adapt their trajectories in real-time to achieve safe and efficient navigation in complex terrains. However, current methods largely depend on visual and IMU (inertial measurement units) that demand high computational resources for real-time applications.In this paper, a real-time terrain identification-based navigation method is proposed using an on-board tapered whisker-based reservoir computing (TWRC) system.The nonlinear dynamic response of the tapered whisker was investigated in various analytical and Finite Element Analysis (FEA) frameworks to demonstrate its reservoir computing capabilities.Numerical simulations and experiments were cross-checked with each other to verify that whisker sensors can separate different frequency signals directly in the time domain and demonstrate the computational superiority of the proposed system, and that different whisker axis locations and motion velocities provide variable dynamical response information.Terrain surface-following experiments demonstrated that our system could accurately identify changes in the terrain real-time and adjust its trajectory to stay on a specific terrain.
Electric field induced extrinsic strains in BaTiO3-epoxy nanocomposite: a contact-less mechanical property tailoring smart material
Authors: Mishra Raghvendra Kumar , Li Danning , Chianella Iva , Goel Saurav , Lotfian Saeid , Nezhad Hamed Yazdani 
Published: December 2022

Abstract
Epoxy is an important class of thermosetting material which have been used in many fields such as aerospace, automobile, and energy sectors. Cured epoxy, however, exhibits poor resistance to crack initiation and growth, thus exhibiting low toughness and brittleness at failure. To improve the mechanical properties, epoxy matrix in polymer composites has been modified by various techniques such as the inclusion of a second phase (e.g., core-shell rubber, thermoplastics or nanofillers) which has demonstrated improved toughness and impact resistance. Very few studies have focused on offering an ‘active toughening’ mechanism in which an increase in toughness and strength is achieved via remote field stimulation such as magnetic, electric or electromagnetic forces. In this study, aerospace grade epoxy resin modified with tetragonal barium titanate (BaTiO3) nanoparticles has been prepared, and its mechanical response has been studied under electric field stimulations. The BaTiO3 nanoparticles have been functionalised with silane coupling agents and dispersed uniformly in epoxy Araldite LY1564 at different content loads (1, 5, 10 wt.%), a diglycidyl ether of bisphenol A (DGEBA) associated with its curing agent Aradur 3487. Several test coupons have been fabricated from such modified epoxy. Real-time in-situ Raman spectroscopy measurement has been conducted on the nanocomposites equipped with electric fields. The results provide a quantitative description of Raman peaks and their intensity variations under the electric field application. The variation of mechanical properties under the application of such fields has also been investigated and analysed alongside the Raman data. The failure stress and strain in the nanocomposites at all BaTiO3 contents examined have been improved in the presence of such fields. The tensile modulus has been increased with the increasing field strength in the 1 wt.% nanocomposites while reduced in the case of 5 and 10 wt.% in the presence of the field. The Raman data have shown a consistent trend of increasing intensity and peaks broadening under the increasing electric field strength and BaTiO3 contents, which is attributed to the softening effect by BaTiO3’s dipolar displacement in the high-content nanocomposites (i.e., 5 and 10 wt.%) which dominates the stiffening trend induced by the electric fields, and observed in the 1 wt.% samples. The mechanism provides an effective route for remote mechanical property tailoring.
Mechanical characterization of FDM parts through instrumented flat indentation
Authors: Lambiase Francesco , Scipioni Silvia Ilaria , Paoletti Alfonso 
Published: December 2022

Abstract
Evaluating local mechanical properties of parts made by Additive Manufacturing processes can improve the deposition conditions. This study proposes a non-destructive characterization test to determine the mechanical behavior of fused deposition modeling (FDM) components. Indentation and compression tests were conducted on samples produced by the FDM process, which were produced by varying the material flow during the deposition. An empirical relationship was determined between yield strength determined through compression and indentation tests. R2 = 0.92 characterized the correlation between the compression and indentation test. The results indicated that both the yield strength measured through compression tests and that measured by the indentation tests increased linearly with the density of the components. Indentation tests provided more insights concerning the tested surface's local characteristics than the compression test.
Certain properties and radius problems for a class ofharmonic mappings defined by an operator
Authors: M Manivannan 
Published: December 2022

Abstract
The geometrical properties of a planar harmonic mapping are stronglyinfluenced by the holomorphic part of the harmonic mapping in the open unitdisc D. The properties of the operator ψ[f](z) = f(z)+f′(z) − 1 for normalisedholomorphic functions in D are studied in this article. We calculate radius offully starlikeness and fully convexity of order α are related to ψ[f](z). We also study closure of certain subclasses of Harmonic functions under convexcombinations.
Determining Mortality Likelihood of Opioid Drug Combinations using Decision Tree Analysis
Authors: Schumaker Robert P. , Veronin Michael A. , Dixit Rohit R. 
Published: December 2022

Abstract
The opioid epidemic is taxing medical infrastructure in terms of patient care and costs. Being able to prioritize care based on expected outcomes could improve patient safety and reduce costs. To investigate, we constructed a decision tree to examine what opioids in conjunction with heroin were most likely to lead to patient death versus their ability to survive. Our model demonstrated that heroin and fentanyl contributed to 77.60% of patient deaths, however, when heroin and fentanyl combinations included oxycodone, patient deaths decreased to 34.78% versus an increase to 81.94% without oxycodone. We speculate that patients already taking oxycodone have built a resistance to opioids allowing them to better survive. Patients taking heroin and fentanyl without oxycodone were more likely to experience cardiac, toxicity and respiratory symptoms whereas these symptoms decreased with the addition of oxycodone.
Monopogen: single nucleotide variant calling from single cell sequencing
Authors: Dou Jinzhuang , Tan Yukun , Kock Kian Hong , Wang Jun , Cheng Xuesen , Tan Le Min , Han Kyung Yeon , HON Chung Chau , Park Woong-Yang , Shin Jay W , Chen Han , Prabhakar Shyam , Navin Nicholas , Chen Rui , Chen Ken 
Published: December 2022

Abstract
Distinguishing how genetics impact cellular processes can improve our understanding of variable risk for diseases. Although single-cell omics have provided molecular characterization of cell types and states on diverse tissue samples, their genetic ancestry and effects on cellular molecular traits are largely understudied. Here, we developed Monopogen, a computational tool enabling researchers to detect single nucleotide variants (SNVs) from a variety of single cell transcriptomic and epigenomic sequencing data. It leverages linkage disequilibrium from external reference panels to identify germline SNVs from sparse sequencing data and uses Monovar to identify novel SNVs at cluster (or cell type) levels. Monopogen can identify 100K~3M germline SNVs from various single cell sequencing platforms (scRNA-seq, snRNA-seq, snATAC-seq etc), with genotyping accuracy higher than 95%, when compared against matched whole genome sequencing data. We applied Monopogen on human retina, normal breast and Asian immune diversity atlases, showing that that derived genotypes enable accurate global and local ancestry inference and identification of admixed samples from ancestrally diverse donors. In addition, we applied Monopogen on ~4M cells from 65 human heart left ventricle single cell samples and identified novel variants associated with cardiomyocyte metabolic levels and epigenomic programs. In summary, Monopogen provides a novel computational framework that brings together population genetics and single cell omics to uncover genetic determinants of cellular quantitative traits.
Hydrazine-Induced Synthesis of CdS Nanorings for the Application in Photodegradation
Authors: Li Haixin , Zheng Chaofan , Wang Zhen , Xu Qingfeng , Meng Fanshuang , Bai Zijun , Yue Wenjin , Nie Guangjun 
Published: December 2022

Abstract
In this paper, CdS nanorings synthesized by facile hydrazine-induced microwave method for the photodegradation of pollutants has been reported for the first time. Different reaction method, microwave power, the category and dosage of pH regulating reagent, reaction temperature and reaction time were investigated. The formation of CdS nanorings from the self-assembly of nanoparticles was attributed to the coordination of hydrazine producing the dipole-dipole interaction among the uniform nanoparticles obtained by microwave method. The crystal phase, composition, morphology and surface property of CdS nanorings were characterized. The results showed that 100 nm-sized wurtzite CdS nanorings with positive surface charges formed by the self-assembly of 5–8 nm nanoparticles, which presented mesoporous structures with maximum pore size of 52 nm. To study the influence of ring-like structures on the photocatalysis, the photodegradation of rhodamine B (RhB) by CdS nanorings and nanoparticles were compared. The results showed that, CdS nanorings displayed higher photodegradation efficiency, which were originated from favorable band edge potential and obviously more effective electron-hole separation producing more superoxide radical and holes as active specifies. The photodegradation path of RhB contains the process as the demethylation, the decarboxylation process, the chromophore cleavage and ring-open reactions. Finally, the available photodegradation of multiple pollutants and reusability of CdS nanorings were carried out.
Cannabidiol/β-cyclodextrin inclusion complex-loaded poly(vinyl alcohol) semi-solid hydrogels for potential use in wound management
Authors: Sangsanoh Pakakrong , Chaiarwut Sonthaya , Choipang Chasuda , Niyompanich Jitti , Suwantong Orawan , Chuysinuan Piyachat , Techasakul Supanna , Lirdprapamongkol Kriengsak , Supaphol Pitt 
Published: December 2022

Abstract
Semi-solid poly(vinyl alcohol) (PVA)-borax hydrogels containing a cannabidiol (CBD)/β-cyclodextrin (β-CD) inclusion complex were prepared and aimed for being used as wound management materials. The inclusion complex was prepared by the co-precipitation method and loaded within PVA semi-solid hydrogels which had various contents of CBD/β-CD inclusion complex (i.e., 0.5%, 1.0%, and 1.5% w/w). The obtained inclusion complexes and their corresponding hydrogels were characterized for their physicochemical properties and mechanical properties. The potential use as wound management of the obtained hydrogels in terms of their release profile, antioxidant activities, antibacterial capabilities, cytotoxicity, and anti-inflammatory efficacy. The CBD/β-CD inclusion complex was successfully prepared, as confirmed by FT-IR, 1H-NMR, XRD, and SEM. The complexation efficiency was 84.73 ± 0.64% and the loading capacity was 32.70 ± 0.32%. The water solubility of CBD was significantly increased to 0.37, which was increased by 16-fold, as compared with that of raw CBD. The cumulatively released amount of CBD from the hydrogels increased with higher amounts of inclusion complex. The prepared hydrogels provided an antibacterial capability with S. aureus and MRSA, while no antibacterial capability was observed for E. coli. However, adding CBD to the hydrogel was beneficial for improving the antioxidant properties of the obtained hydrogels. All the hydrogels loaded with the CBD/β-CD inclusion complex at concentrations below 1.25 mg/mL for the extraction medium were non-cytotoxic towards RAW 264.7 cells and also provided the ability to suppress nitric oxide (NO) production by more than 75% compared with the LPS treated group. These findings suggest a new application for semi-solid PVA-borax hydrogels containing the CBD/β-CD inclusion complex in biomedical applications.
External validation of standardized KELIM and platinum resistant recurrence score in patients with advanced epithelial ovarian cancer
Authors: Oufkir Nina , Rouzier Roman , Paoletti Xavier , Bonneau Claire 
Published: December 2022

Abstract

Background
Neoadjuvant chemotherapy followed by interval debulking surgery is today a valid treatment option for advanced epithelial ovarian cancer (EOC). This schema allows in vivo evaluation of the chemosensitivity of the tumor, however there is still no clearly validated marker. The Standardized CA-125 ELIMination rate constant K (Std KELIM) and the Platinum Resistant Recurrence (PtRR) Score have been proposed as markers. The aim of our study was to validate these two tools for predicting platinum sensitivity in a real-world population with advanced EOC.
Experimental design:
All patients with advanced EOC treated with neoadjuvant chemotherapy followed by interval debulking surgery in Institut Curie between 2000 and 2015 were included. Std KELIM was calculated with the CA-125 concentrations at each cycle. The predictive value of Std KELIM and the validation of the PtRR Score regarding the risk of subsequent platinum-resistant relapse were assessed using ROC curve, logistic regression and calibration curve.
Results
Std KELIM was calculated for 152 patients. The AUC was 0.67 with an optimal threshold at 0.61. A low Std KELIM was significantly associated with PtRR (odds-ratio = 0.19 (95% CI [0.06, 0.53], p = 0.002) in the univariate analysis but not in the multivariate analysis after adjustment on complete IDS status, which was the only independent predictive factor. The calibration curve of PtRR score presents a slight but significant underestimation (p = 0.02) of the risk of platinum-resistant relapse.
Conclusions
Std KELIM and PtRR score are early predictive markers of platinum resistance. They could be used in a clinical trial for assisting the clinician in adapting medical treatment.
Membranous nephropathy in chronic lymphocytic leukemia responsive to ibrutinib: a case report
Authors: Turcotte Anna-Eve , Glass William F. , Lin Jamie S. , Burger Jan A. 
Published: December 2022

Abstract
Background
Membranous nephropathy (MN) is an uncommon renal presentation in patients with chronic lymphocytic leukemia (CLL), and as such, there is no standard therapy for these patients. Ibrutinib, a small molecule kinase inhibitor that irreversibly binds to Bruton’s tyrosine kinase (BTK), has become a standard targeted treatment for CLL patients. Ibrutinib inhibits CLL cell proliferation and causes leukemia cell death, but its efficacy in CLL associated renal impairment due to paraneoplastic MN has not previously been described. Here we report the first case of MN in a patient with CLL treated with ibrutinib with complete renal response.
Case presentation:
A 63-year-old male with a recent diagnosis of early stage CLL (RAI stage 0) presented with complaints of fatigue, weight loss, and worsening lower extremity edema. Laboratory results revealed an elevated serum creatinine level of 1.38 mg/dl (baseline 1.20 mg/dl), hypoalbuminemia (albumin 2.4 g/dl), and a 24 h urinary protein excretion of 17.9 g. A percutaneous renal biopsy confirmed the diagnosis of MN and the patient was initiated on corticosteroids and ibrutinib therapy. After 10 months of follow-up, the serum creatinine recovered to baseline, the serum albumin level improved to 3.2 g/dl with a spot urine protein/creatinine ratio of 0.66 g. The CLL was also noted to be inactive.
Conclusions
To our knowledge this is the first report of a patient with CLL and paraneoplastic MN responsive to BTK inhibitor therapy. This presentation underlines the importance of recognizing rare glomerular diseases that may occur with CLL and offers a new therapeutic avenue to the treatment of CLL-associated MN.