bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colorectal Cancer-Associated Bacterial Genes Are Widely Encoded In Human Microbiomes
Authors: Minot Samuel , Li Naisi , Koester Sean , Yu Ming , Dominitz Jason , Grady William , Dey Neelendu 
Published: August 2022

Abstract

The gut microbiome is an environmental driver of colorectal cancer (CRC). Although multiple gut bacterial species have been linked to CRC, each is detectable in a minority of CRC cases. Therefore, we postulated the existence of CRC-associated microbes more numerous and diverse than what is currently recognized. We performed a large-scale meta-analysis of metagenomic datasets from global gut microbiome surveys of CRC cohorts. By performing de novo clustering of co-abundant genes (CAG), we identified CRC-associated organisms with sub-species level resolution without the confounding effects of presupposed taxonomic hierarchies. This gene-level analysis disclosed 2,319 CAGs comprised of 427,261 bacterial genes significantly enriched or depleted in CRC that are widely encoded in genomes of diverse commensal organisms (an estimated 23-40% of gut bacteria), including taxa not previously linked to CRC. We demonstrated causality in gnotobiotic ApcMin/+ mice using defined bacterial consortia and human fecal samples: microbiomes harboring CRC-associated CAGs were more tumorigenic than microbiomes with health-associated genomic signatures. Bulk and single-cell RNA sequencing disclosed that tumorigenicity of the microbiome can be mediated through effects on the microenvironment rather than direct intestinal epithelial cell growth promotion. Together, these data offer proof-of-principle for microbiome-based personalized CRC risk profiling.
Advanced HCC precision modeling reveals divergent responses to combinatorial immunotherapy
Authors: Liu Jinping , Cheng Lan , El-Mekkoussi Hilana , Lee Michelle , Jaffe Danielle , Gavin-Darby Kaisha , Morgan Ashleigh , Manduchi Elisabetta , Schug Jonathan , Kaestner Klaus 
Published: August 2022

Abstract
Combinatorial immunotherapy (CIT) has afforded patients with advanced HCC a potential for long-term survival. However, sustained responses are seen only in a minority of patients. Thus, there is an unmet need for precision modeling to differentiate responder vs. non-responders and uncover predictive biomarkers. Here, we establish mouse models to mimic genetic alterations of human HCC by either overexpression of MYC and Tgfa (MycOE;TgfaOE) or by combining activated b-catenin with inactivated p53 (N90-CTNNB1OE;Trp53-/-). We then performed in-depth testing to analyze the response to CIT and characterize the immune profiles. The less proliferative N90-CTNNB1OE; Trp53-/- tumors were sensitive to CIT and developed tertiary lymphoid structures (TLSs). In contrast, faster growing MycOE;TgfaOE tumors circumvent CIT with T-cell exclusion. Importantly, early TLS initiation and T-cell exclusion features predict the therapeutic response prior to CIT. Together, these data establish that precision mouse models can mimic differential responses to CIT, with implications for developing predictive biomarkers and tailored therapy.
High Speed and Area Efficient Address Generator architecture for WiMAX Deinterleaver
Authors: Perumal Vivek Karthick , Jayabalan Ramesh 
Published: August 2022

Abstract
In this paper, A VLSI Implementation of High Speed and Area Efficient Address Generation architecture for deinterleaver in WiMAX applications. The emphasis of the design is to reduce the complexity and high speed to optimize the design. This design for WLAN IEEE 802.16e (WiMAX) Standard has designed an efficient hardware resource implemented in FPGA and ASIC environments. A simple architecture was designed with better performance than an existing one. The multiplier-less architecture which satisfies the area efficacy, clock latency, and delay. The Modified QPSK, 16QAM, and 64 QAM standard systems with standard code rate was designed. This approach provides a significant improvement in hardware resources.
An event-oriented database of droughts in Europe based on spatio-temporal clustering
Authors: Cammalleri Carmelo , Navarro Juan Camilo Acosta , Bavera Davide , Diaz Vitali , Ciollo Chiara , Maetens Willem , Magni Diego , Masante Dario , Spinoni Jonathan , Toreti Andrea 
Published: August 2022

Abstract
Droughts evolve in space and time without following borders or pre-determined temporal constraints. Here, we present a new database of drought events built with a three-dimensional density-based clustering algorithm. The chosen approach is able to track the spatio-temporal evolution of an event, and it was tuned against a set of past global droughts characterized independently by multiple experts. About 200 events were detected over Europe in the period 1981–2020 using SPI-3 (3-month cumulated Standardized Precipitation Index) maps derived from the ECMWF (European Centre for Medium-range Weather Forecasts) 5th generation reanalysis (ERA5) precipitation. The largest European meteorological droughts during this period occurred in 1996, 2003, 2002 and 2018. A good agreement between the major events identified by the algorithm and drought impact records was found, as well as with previous datasets based on pre-defined regions.
Aerosol jet printing polymer dispersed liquid crystals on highly curved optical surfaces and edges
Authors: DAVIES MATTHEW , HOBBS MATTHEW J. , NOHL JAMES , DAVIES BENEDICT , RODENBURG CORNELIA , WILLMOTT JON R. 
Published: August 2022

Abstract
We demonstrate a new technique for producing Polymer Dispersed Liquid Crystal (PDLC) devices utilising aerosol jet printing (AJP). PDLCs require two substrates to act as scaffold for the Indium Tin Oxide electrodes, which restricts the device geometries. Our approach precludes the requirement for the second substrate by printing the electrode directly onto the surface of the PDLC, which is also printed. The process has the potential to be precursory to the implementation of non-contact printing techniques for a variety of liquid crystal-based devices on non-planar substrates. We report the demonstration of direct deposition of PDLC films onto non-planar optical surfaces, including a functional device printed over the 90° edge of a prism. Scanning Electron Microscopy is used to inspect surface features of the polymer electrodes and the liquid crystal domains in the host polymer. The minimum relaxation time of the PDLC was measured at 1.3 ms with an 800 Hz, 90 V, peak-to-peak (Vpp) applied AC field. Cross-polarised transmission is reduced by up to a factor of 3.9. A transparent/scattering contrast ratio of 1.4 is reported between 0 V and 140 V at 100 Hz.
A stepwise-clustered heat stress downscaling approach to analyze future variations of heat stress in East China
Authors: Yu Bizheng , Huang Guohe , Zhou Xiong , Wang Shuguang , Li Yongping , Wu Yinghui , Ren Jiayan 
Published: August 2022

Abstract
In this study, the fifth generation ECMWF reanalysis (ERA5) reanalysis datasets and three global climate models (GCMs) were selected as the inputs of the stepwise-clustered heat stress downscaling (SCHSD) method to simulate the future heat stress indices in East China. The heat stress indices included the Heat Index (HI), Humidex (HUMIDEX) and the simplified Wet Bulb Globe Temperature (sWBGT). Three GCMs (i.e., CanESM5, INM-CM4-8 and MPI-ESM1-2-HR) under two Shared Socioeconomic Pathway (SSP245 and SSP585) were input into the SCHSD model to develop downscaled climate projections. To verify the SCHSD model, the reproduction results from three GCMs during the period of 1990–2014 were compared to daily observational data (i.e., HI, HUMIDEX and sWBGT). The verification results suggest that the coefficient of determination (R2) of the stations in the northern part of East China mostly exceeds 0.8, while the R2 of the stations in the southern part of East China is mostly in the range of 0.6 to 0.8. The projection results suggest that the future heat stress in East China would generally maintain an upward trend from 2021 to 2100. The largest change in heat stress is projected in June under the period of 2021–2100. The results also show that the highest average of days in the danger category is 78.9 in summer under the SSP585 scenario, accounting for 86% of the total summer (June, July and August).
Thresholding Methods in Non-Intrusive Load Monitoring to Estimate Appliance Status
Authors: Precioso Daniel , Gómez-Ullate David 
Published: August 2022

Abstract
Non-Intrusive Load Monitoring (NILM) aims to predict the status or consumption of domestic appliances in a household only by knowing the aggregated power load. NILM can be formulated as regression problem or most often as a classification problem. Most datasets gathered by smart meters allow to define naturally a regression problem, but the corresponding classification problem is a derived one, since it requires a conversion from the power signal to the status of each device by a thresholding method. We treat three different thresholding methods to perform this task, discussing their differences on various devices from the UK-DALE dataset. We analyze the performance of deep learning state-of-the-art architectures on both the regression and classification problems, introducing criteria to select the most convenient thresholding method.
Characteristics, mortality, and risk factors in patients with systemic sclerosis-associated interstitial lung disease
Authors: Jang Hye Jin , Woo Ala , Kim Song Yee , Yong Seung Hyun , Park Youngmok , Chung Kyungsoo , Lee Su Hwan , Leem Ah Young , Lee Sang Hoon , Kim Eun Young , Jung Ji Ye , Kang Young Ae , Kim Young Sam , Park Moo Suk 
Published: August 2022

Abstract
Background
Systemic sclerosis (SSc) is a heterogeneous autoimmune disease characterized by the dysregulation of fibroblast function, causing multi-organ damage, which often involves the lungs. Combined interstitial lung disease (SSc-ILD) is a major cause of death among patients with SSc. Our study aimed to identify the risk factors for mortality and compare the clinical characteristics of patients with SSc-ILD.
Methods
Patients were retrospectively enrolled between 2010 and 2018 in a tertiary hospital in Korea. Patients with SSc-ILD were classified into two groups depending on the first pulmonary function test or radiologic findings: extensive (n = 46, forced vital capacity [FVC] < 70% or > 20% disease extent on CT scan) or limited (n = 60, FVC ≥ 70% or < 20% disease extent on CT scan).
Results
Patients in the extensive group were younger (mean age ± SD 49.3 ± 11.5) than those in the limited group (53.9 ± 12.5, p = 0.067). The extensive group showed frequent pulmonary hypertension (43.5% vs. 16.7%, p = 0.009), higher erythrocyte sedimentation rate (61.3 ± 33.7 vs 42.1 ± 26.0, p = 0.003), and mortality (32.6% vs. 10.0%, p = 0.011). ILD was detected within five years from the first visit (mean number of years 3.2 ± 3.9 vs. 4.3 ± 5.5, survivors vs. non-survivors), and mortality occurred in 19.8% of all patients during a 15-year follow-up. Older age, lower FVC, and combined malignancy were associated with mortality, but FVC decline was similar in the limited and extensive groups, such as 15–20% in the first year and 8–10% in the next year, regardless of the initial extent of the disease.
Conclusions
Patients with SSc-ILD had a heterogeneous disease course. Approximately 10% of the patients in the limited group showed progression, which was similar to the proportion of patients in the extensive group. ILD was detected within the first five years of the total follow-up period; therefore, it is necessary to carefully monitor patients’ symptoms and signs from the early stage. Long-term surveillance is also required.
The Ankle-Brachial Index for assessing the prevalence of peripheral artery disease and cardiovascular risk in patients with type 2 diabetes mellitus
Authors: Sartore Giovanni , Caprino Rosaria , Ragazzi Eugenio , Bianchi Lorenza , Lapolla Annunziata , Piarulli Francesco 
Published: August 2022

Abstract

Background.
Type 2 diabetes mellitus (T2DM) is an important risk factor for peripheral artery disease (PAD). Measuring the Ankle-Brachial Index (ABI) in patients with diabetes is a simple way to screen for PAD. In the last decade, pathological ABI values (≤ 0.9; ≥1.3) were found associated with a higher cardiovascular (CV) risk and mortality. The role of classic risk factors for PAD in patients with diabetes is still unclear, and there is no specific PAD risk scoring system for these patients. The main goals of this study were to establish the prevalence of PAD in a T2DM population, and assess the relationship between PAD and the CV risk calculated with the CUORE Project score (CPS) (https://www.cuore.iss.it/). The association between the ABI, the main risk factors for PAD and T2DM complications was also investigated.
Methods.
Two hundred patients attending the Diabetes Clinic run by the ULSS 6 District Health Unit in Padua (north-east Italy) were consecutively enrolled, and their left and right ABI were measured. Twenty-seven patients with a history of CV events were excluded for the purpose of calculating the CPS, which was thus recorded for a total of 173 patients.
Results.
The prevalence of PAD in this study population was 17%. The CV risk calculated with the CPS tended to be higher (p = 0.0712) in the group with a pathological ABI than in the group with a normal ABI (0.91–1.29). The distribution of patients in the different CV risk classes did not differ significantly (p = 0.2208) between the two groups (pathological vs normal ABI). Glycated hemoglobin (r = -0.1591; p = 0.0244), total cholesterol (r = -0.1958; p = 0.0054), LDL cholesterol (r = -0.1708; p = 0.0156) and systolic blood pressure (r = -0.1523; p = 0.0313) correlated significantly and inversely with the left ABI. The frequency of diabetic retinopathy differed significant (p = 0.0316) between the two groups (pathological vs normal ABI), and was higher in the group with a pathological ABI.
Conclusions.
The data collected reveal a high prevalence of PAD in patients with T2DM, consistently with studies conducted in other countries. The CPS confirmed that patients with a pathological ABI have tendency to a higher CV risk. Overall, the present results point to the importance of an accurate CV assessment – also measuring individuals’ ABI and calculating their CPS - to better pinpoint those at high risk of PAD, especially among patients with T2DM.
WITHDRAWN: Insights in the Scavenging Mechanism of Trichloromethyldioxy Radical with Lycopene: a DFT/TD- DFT Study
Authors: Taherkhani Behnaz , Taherkhani Mahboubeh , Zanjanchi Farzaneh 
Published: August 2022

Abstract
The antioxidant action of lycopene as an alkyl peroxyl radical (CCl3O•2) scavenger through electron transfer, hydrogen abstraction and radical addition mechanisms has been investigated in the gas, non-polar and polar phases using density functional theory and the conductor like polarizable continuum model, CPCM, to account for solvents effect at the B3LYP/6-31G** level of theory. Results reveal that for fully optimized complexes, there is a stabilizing attraction between CCl3O•2 radical and lycopene that its value in polar phase is more than none-polar phase and in none-polar phase is more than gas phase. Thermodynamic studies reveal that transfer electron process in polar solvent at room temperature is more desirable than other reactions. The global reactivity parameters of ionization potential, IP, electron affinity, EA, electroaccepting, ω+, and electrodonating, ω−, HOMO-LUMO gap, ∆, chemical potential, µ, chemical hardness, η, show that lycopene is considered as a good electron donor compared to CCl3O•2 radical and the antioxidant property of lycopene in polar solvent is more than non-polar solvent and cavity. The calculated λmax via time dependent-density functional theory, TD-DFT, has a bathochromic shift due to interactions of CCl3O•2 radical with lycopene, so that lycopene becomes almost colorless after radical adsorption in polar and non-polar solutions. The calculated values of dipole moment and solubility Gibbs free energy, ∆Gsolv, confirm more solubility of lycopene and its complex with radical in polar phase than non-polar phase. The obtained results can aid in the understanding of different possible mechanisms that may be involved in the prevention of some illness.
Wearable perovskite solar cells by aligned liquid crystal elastomers
Authors: Huang Zengqi , Li Lin , Wu Tingqing , Xue Tangyue , Sun Wei , Pan Qi , Wang Huadong , Xie Hongfei , Chi Jimei , Han Teng , Su Meng , Song Yanlin 
Published: August 2022

Abstract
In a flexible perovskite solar cell (PSC), the bottom interface between perovskite and the electron-transporting layer is critical in determining its efficiency and reliability. High defect concentrations and crystalline film fracturing at the bottom interface substantially reduce the power conversion efficiency (PCE) and the operational stability. In this work, a liquid crystal elastomer (LCE) interlayer is intercalated into a flexible PSC for the first time with the charge transfer channel toughened by the aligned mesogenic assembly. The molecular ordering is instantly locked upon photopolymerization of liquid crystalline diacrylate monomers and dithiol-terminated oligomers. The optimized charge collection and the minimized charge recombination at the interface boost the PCE up to 23.26% and 22.10% for rigid and flexible devices, respectively. The LCE-induced suppression of phase segregation endows the unencapsulated PSC with a T80 lifetime over 1570 h. Moreover, the aligned LCE interlayer preserves the configuration integrity with remarkable repeatability and mechanical robustness, which enables the flexible PSC to retain 86% of its original efficiency after 5000 bending cycles. The flexible solar cell chips are further integrated into a wearable haptic device with microneedle-based arrays of sensors to demonstrate a pain sensation system in virtual reality.
The association between Arsenic levels and oxidative stress in myocardial infarction: A case-control study
Authors: Sagha Arian , Shiri Hamidreza , Juibari Kobra Bahrampour , Mehrabani Mehrnaz , Nasri Hamid Reza , Nematollahi Mohammad Hadi 
Published: August 2022

Abstract
Background
Cardiovascular diseases (CVDs) are known as the first causes of death throughout the world, and mainly myocardial infarction (MI), lead to 7.4 million deaths annually. Atherosclerosis is the major underlying cause of most CVDs. However, exposure to heavy metals, among other factors, deserves further attention as a risk factor for CVDs. This study was designed to evaluate the levels of arsenic (Ars) in myocardial infarction (MI) patients and healthy individuals as well as assess the association between the incidence of MI and Ars, total antioxidant capacity (TAC), and oxidative stress (OS).
Methods
This case-control study was conducted among patients with MI (n = 164) and normal individuals (n = 61) at Shafa Hospital in Kerman, Iran. Patients were classified into two groups, including coronary artery blocks above 50% (CAB > 50%, n = 83) and coronary artery blocks less than 50% (CAB < 50%, n = 83) based on their angiography findings. The demographic characteristics, clinical history, biochemical parameters, and serum Ars and TAC levels were evaluated.
Result
In the present study, both CAB groups had significantly reduced levels of TAC compared with the control. Furthermore, TAC was lower in the CAB>%50 group compared to the CAB<%50 group. Ars levels were significantly higher in both CAB groups compared with the control. There was a significant positive relationship between CAB and Ars, BG, HbA1c, urea, creatinine, TG, TC, and LDL-c, as well as a negative relationship between HDL-c and TAC. Moreover, TAC levels showed a significant inverse correlation with Ars, HbA1c, and creatinine, and a positive correlation with HDL-c. As risk factors, Ars, hs-CRP, TG, TC, and LDL-c enhance the severity of the disease, and HDL-c and TAC decrease the disease severity. Moreover, ROC curve analysis revealed that the highest AUC for the CAB>%50 (AUC = 78.29), and cytotoxic levels for both CAB groups (Ars ≥ 0.105 ppm), and no significant differences were found between the two groups.
Conclusion
Our findings suggest that Ars at ≥ 0.105 ppm is able to increase the risk of MI through the increased OS and decreased TAC.
WITHDRAWN: Nomogram for predicting the overall survival for young-onset colorectal cancer with liver metastases: a SEER database analysis
Authors: Li Tao , Liao Hualin , Li Mingming , Liu Yaxiong , Liang Yahang , Li Taiyuan 
Published: August 2022

Abstract
Background:
This study aimed to identify independent clinicopathologic factors associated with overall survival (OS) of Young-onset colorectal cancer with liver metastases (YO-CRCLM) and then construct and validate a prognostic nomogram for patients with YO-CRCLM.
Methods
We rigorously screened eligible YO-CRCLM patients diagnosed from January 2010 to December 2018 from the Surveillance, Epidemiology, and End Results (SEER) database and then randomly divided them into a training and a validation cohort. The prognostic indicators were screened by univariate and multivariate cox regression analysis. The nomogram predicted the 1-, 3- and 5-year OS based on the selected prognostic factors. The model was internally validated in testing cohort. The accuracy, reliability, and clinical utility of the model were assessed using the operating characteristic curve (ROC), the area under the curve (AUC), calibration curve, and decision curve analysis (DCA), respectively. Different risk subgroups of prognosis were determined based on the nomogram scores in training cohort of YO-CRCLM.
Results
2976 patients with YO-CRCLM from the SEER database were eventually included in the study. The nomogram model incorporated ten independent prognostic risk factors to predict 1-, 3-, and 5-year OS based on univariate and multivariate cox regression. The ROC curve analysis showed that the area under the curve (AUC) of the training and validation cohorts exceeded 0.7 at 1, 3, and 5 years. Internal validation of calibration curves and DCA showed good stability and clinical utility values.
Conclusion
Nomogram predicting OS for YO-CRCLM patients was built and had an excellent performance, which will help clinical decision-making and formulation of the individualized treatment for YO-CRCLM patients.
Lithium chloride effectiveness on Dermacentor reticulatus is confirmed in vitro
Authors: Kolics Balázs , Mátyás Kinga , Solti Izabella , Bacsi Zsuzsanna , Kovács Szilvia , Staszny Ádám , Taller János , Kolics Éva 
Published: August 2022

Abstract
Dermacentor reticulatus is considered a significant parasite because of the many diseases it spreads, which are dangerous to humans and animals. Control by repellents and pesticides, short duration of action or environmental damage and development of resistance make it impossible to achieve sustainable control. New active substances are constantly needed, and natural agents are given priority. Lithium salts have been shown to be effective against the related bee pest, Varroa destructor, a mite species, also by contact mode of action. In the present study, we investigated whether the contact efficacy of lithium chloride extends to other parasitic species such as D. reticulatus. Our results uncovered for the first time that beyond Varroa destructor the effectiveness of lithium chloride extends to the dog tick, offering 100% mortality at concentrations of 5.52 M, 2.76 M and 1.38 M. However, further comprehensive studies under in vivo conditions are warranted to ensure the relevance for practical application.