bluuebunny/crossref_metadata_2025_split huggingface dataset:
Musculoskeletal pain is prevalent in Chinese medical and dental students: A cross-sectional study
Authors: Lin Yunzhi , Zhang Xuehui , Li Hongyan , Huang Ying , Zhang Wenming , Zhang Chaofan 
Published: November 2022

ObjectivesMusculoskeletal pain (MSP) is a major reason for consultation in primary care and is becoming increasingly prevalent among medical students. There is little research on the current situation of MSP among Chinese medical and dental students. Data on the analysis of risk factors related to MSP are also limited. The objectives of this study were to investigate the prevalence and characteristics of MSP among Chinese medical and dental students and to explore the risk factors for MSP and students' intent to seek medical treatment.MethodsAn anonymous, internet-based, cross-sectional, open survey was distributed to medical and dental students at Fujian Medical University, Fuzhou, China. Data on the demographic information and characteristics of MSP were collected and analyzed. In addition to descriptive statistics, logistic regression was used to analyze significant risk factors contributing to MSP.ResultsA total of 1,178 students responded to the survey (response rate = 79.6%), including 722 medical students and 456 dental students. The age ranged from 16 to 24. There were 553 male students and 625 female students. A total of 523 students reported neck pain (NP, 44.4%), 361 students reported low back pain (LBP, 30.6%), and 182 students reported joint pain (JP, 15.4%). Sixty-six students (5.6%) simultaneously suffered from NP, LBP, and JP. The prevalence of NP (49.1 vs. 41.4%, P = 0.01), LBP (34.6 vs. 28.1%, P = 0.02), and JP (20.2 vs. 12.5%, P &lt; 0.001) was significantly higher in dental students than in medical students. The prevalence of MSP was significantly different among the academic years for NP and LBP (P = 0.02 and P &lt; 0.001, respectively). Univariate and multivariate regression analyses demonstrated that female sex, PSS-10 score, and major of stomatology were risk factors for MSP. Medical and dental students' intention to seek treatment for MSP was low and was significantly associated with the severity of pain.ConclusionsThe prevalence of MSP in Chinese medical and dental students is high, especially for NP and LBP, and is significantly higher in dental students than in medical students. The prevalence of NP and LBP were significantly different among academic grades. Female sex, PSS-10 score, and major of stomatology were risk factors for MSP. Students' intent to seek treatment for MSP was very low and was determined by the severity of pain.
Correlation between clinical trial endpoints of marketed cancer drugs and reimbursement decisions in China
Authors: Ling Kexin , Qin Huli , Feng Yiman , Che Hongxi , Ding Jinxi , Li Wei 
Published: November 2022

ObjectiveThis study aimed to assess whether different clinical trial endpoints in pivotal trials of cancer drugs were associated with reimbursement decisions in China.Materials and methodsCancer drugs marketed before June 30th, 2021 with publicly available technical review reports for application of drug registration on Center for Drug Evaluation (CDE) website were reviewed. The trial design characteristics and relevant clinical outcomes [e.g., overall survival (OS), progression-free survival (PFS) and objective response rate (ORR)] were extracted from the technical review reports, while the reimbursement decisions were reviewed from National Healthcare Security Administration (NHSA) website. The differences in trial characteristics and clinical outcomes between drugs with positive reimbursement decisions and negative ones were compared by hypothesis test (Pearson's chi-squared test, Fisher's exact test, independent samples t-test and Mann-Whitney U test). The correlation between different clinical trial endpoints and reimbursement decisions was analyzed by multivariate logistic regression.ResultsThere were 112 cancer drug indications included in this study. Among these indications, 76 received a positive reimbursement decision, and the most common primary endpoints of them were PFS (42.1%) and ORR (30.3%). Taking PFS (OR = 7.333) and ORR (OR = 5.271) as the primary endpoints were more likely to receive a positive reimbursement decision compared with OS (P = 0.003). The proportion of drugs marketed with phase I (75.0%) and phase II (85.7%) clinical trials receiving positive reimbursement decisions are significantly higher than those marketed with phase III clinical trials (61.3%, P = 0.043). The magnitude of clinical benefit only had subtle influences (Prisk benefit − OS = 0.627, Prisk benefit − PFS = 0.087, Psurvival benefit − OS = 0.545, Psurvival benefit − PFS = 0.189) on the drug reimbursement decisions, however, the drug prices and clinical needs also made a difference on that.ConclusionThis study found that, in Chinese drug price negotiations from 2017 to 2021, policymakers have focused more on meeting clinical needs and filling therapeutical gaps in National Reimbursement Drug List (NRDL), while requirements for the selection of primary endpoints, clinical trial phases, and clinical benefits have been reduced. In the future, emphasis should be put on the use of surrogate endpoints and clinical benefits.
Age-related brain atrophy in cats without apparent neurological and behavioral signs using voxel-based morphometry
Authors: Hamamoto Yuji , Yu Yoshihiko , Asada Rikako , Mizuno Satoshi , Hasegawa Daisuke 
Published: November 2022

IntroductionBrain atrophy is observed with aging and may cause cognitive decline or dysfunction. Aging cats may demonstrate behavioral changes related to cognitive dysfunction. In the clinical veterinary field, although the conventional region of interest method by manual or semiauto tracing on magnetic resonance imaging is used to detect atrophy of regional structures, such as the hippocampus, it is difficult to assess atrophy globally. Voxel-based morphometry (VBM) has been developed to detect global and regional abnormalities in humans. The purpose of the present study investigates whether the feline brain volume decreases with aging using VBM analysis.MaterialsA total of 65 cats, aged 17–200 months, without apparent neurological and behavioral signs were included in the statistical analysis.ResultsWe observed that the gray matter in the bilateral parietal lobes was decreased significantly with aging. The regions that showed decreased volume included the right postcruciate, cingulate gyrus, rostral suprasylvian/ectosylvian gyri, and the left postcruciate gyrus. No significant reduction in white matter was observed. Together, our results show that age-related brain atrophy can be detected using VBM analysis.DiscussionThe age-related atrophy of the parietal cortex may not cause neurological and behavioral signs in cats. Therefore, veterinarians should consider age when assessing the relation between morphometric and functional abnormalities of the parietal cortex in cats.
Investigation of Energy Levels of Small Vacancy Clusters in Proton Irradiated Silicon by Laplace Photoinduced Transient Spectroscopy
Authors: Kamiński Paweł , Żelazko Jarosław , Kozłowski Roman , Hindrichsen Christian , Jensen Leif 
Published: November 2022

Laplace photoinduced transient spectroscopy has been applied to determine the electronic properties and concentrations of deep traps in high purity n-type silicon irradiated with high fluences of 23-MeV protons. From the temperature dependence of thermal emission rates of excess charge carriers obtained by the analysis of the photocurrent relaxation waveforms measured at temperatures of 30–320 K, eight deep traps with activation energies ranging from 255 to 559 meV have been resolved. The dependence of these trap’s concentrations on the proton fluence are demonstrated for the fluence values ranging from 1 × 1014 to 5 × 1015 neq/cm2. In comparison to the previously reported results of theoretical and experimental studies on the electronic properties of small vacancy clusters in irradiated silicon, we tentatively attribute four detected traps with activation energies of 255, 367, 405, and 512 meV to the energy levels related to the 2−/− charge state changes of divacancy (V2), trivacancy (V3), tetravacancy (V4), and pentavacancy (V5), respectively. Simultaneously, we propose the attribution of four deep traps with higher activation energies of 415, 456, 526, and 559 meV to the energy levels related to the −/0 charge state changes of these small vacancy clusters, respectively.
The Aluminum Abundance of HD 209459 from Far Ultraviolet and Optical Spectra
Authors: Monier Richard 
Published: November 2022

Abstract
The abundance of aluminum in the atmosphere of HD 209459 is measured by synthesizing selected optical and ultraviolet lines having high quality atomic data. The Al iii resonance lines at 1854.12 and 1862.79 Å are reproduced by an aluminum underabundance of about 0.3 times the solar aluminum abundance. The Al ii line at 4663.06 Å is properly fit by a solar aluminum abundance. This difference needs confirmation by the modeling of more lines in both spectral regions.
Role of MicroRNAs in the Development of Chronic Liver Disease in Hepatitis Virus-Infected Egyptian Population
Authors: Hassan Marwa , El-Ahwany Eman , Elzallat Mohamed , Rahim Ali Abdel , Abu-Taleb Hoda , Abdelrahman Yosry , Hassanein Moataz 
Published: November 2022

Background: The identification of miRNAs that play a role in the regulation of the viral life cycle and its related liver illness opens the door to the development of diagnostic biomarkers that can categorize patients at higher risk for developing end-stage liver disease. This study was designed to investigate the role of miRNAs in the development of viral hepatitis-induced chronic liver disease (CLD) in the Egyptian population, as well as their potential as possible diagnostic biomarkers for chronic hepatitis virus infection.
Methodology: The study involved 100 CLD patients; 55 cases of hepatitis C virus (HCV) and 45 cases of non-viral hepatitis, in addition to 40 healthy controls. The expression of five miRNAs (miR‐30, miR‐122, miR‐296, miR‐351, and miR‐431) was assessed using real-time PCR.
Results: Serum levels of miR‐30, miR‐122, miR‐296, miR‐351, and miR‐431 were significantly higher in all patients than the control group (p<0.01). Also, they were significantly greater in viral hepatitis cases compared to the non-viral hepatitis group (p<0.01). The sensitivities and specificities of miR-122a, miR‐30, miR‐296, miR‐351, and miR‐431 were (85.71%, 83.33%), (82.35%, 83.33%), (85.71%, 69.44%), (88.64%, 75.76%), and (87.80%, 65.79%), respectively.
Conclusions: miR‐30, miR‐122, miR‐296, miR‐351, and miR‐431 play key roles in the development of CLD as a consequence of viral infection. So, they have the potential to be targeted for the early detection of chronic hepatitis virus infection and allow for exploring a new frontier in the discovery of innovative therapeutics to combat chronic viral infection and its serious life-threatening complications including liver cancer.
South American 2020 regional smoke plume: intercomparison with previous years, impact on solar radiation, and the role of Pantanal biomass burning season
Authors: Rosário Nilton Évora do , Sena Elisa Thomé , Yamasoe Marcia Akemi 
Published: November 2022

Abstract. The 2020 biomass burning season in Brazil was marked by an atypical amount of fire across the Pantanal biome, which led to high levels of smoke within the biome and downwind areas. The present study analyzes fire counts and smoke over Pantanal in 2020, comparing this particular year's data with those from the previous 17 years (2003–2019). Taking as reference the most-polluted years in this period, the regional smoke plume and its impact on surface solar radiation were also evaluated. In 2020, the regional smoke plume core covered an area of ∼ 2.6×106 km2 at the peak of the burning season, an area well above that of the previous 6 years but smaller than areas observed in a more remote past, as in 2007 and 2010 (> 5.0×106 km2). The smoke loading was lower (mean aerosol optical depth, AOD, of 550 nm; ∼ 0.7) than that of 2007 and 2010 (mean AOD 550 nm; ∼ 1.0). The plume radiation absorption efficiency, when compared with the previous year's plumes, did not present significant differences. Regarding the Pantanal burning season, it revealed some atypical features. Fire counts were up to 3.0 times higher than for the years from 2003 to 2019. Smoke loading over Pantanal, which is typically a fraction of that over Amazonia, was higher in 2020 than that over Amazonia, an indication that local smoke surpassed the smoke advection from upwind regions. The observed intraseasonal variability in smoke over Pantanal revealed to be largely driven by the nature of the burned areas in the biome. From September on, there was a significant increase in fire count in conservation and indigenous areas, where higher biomass density is present, which would explain the larger smoke plumes over Pantanal, even during October when the fire count was reduced. In October, the biome was covered by a thick smoke layer, which resulted in a mean deficit of surface solar radiation up to 200 W m−2. Despite the Pantanal biomes' massive burning in 2020, the regional smoke plume was not far from its climatological features. Nevertheless, the Pantanal 2020 burning season represents the worst combination of a climate extreme applied to a fire-prone environment, coupled with inadequately enforced environmental regulations, from which there is much to be learned.
Tingkat Pertumbuhan dan Kelangsungan Hidup Benih Ikan Gabus ( Chana striata Blkr ) dengan Frekuensi Pemberian Pakan Buatan
Authors: Syahruddin Syahruddin 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh tingkat pertumbuhan dan kelangsungan hidup ikan gabus dengan frekuensi pemberian pakan buatan. Penelitan ini dilaksanakan di Hatchery air tawar Politeknik Pertanian Negeri Pangkep. Hewan uji yang digunakan dalam penelitian ini adalah benih ikan gabus. Peubah yang diamati adalah pertumbuhan dan tingkat kelangsungan hidup. Rancangan Percobaan yang digunakan adalah rancangan acak lengkap (RAL) yang terdiri dari 3perlakuan 3 ulangan. Data dianalisis dengan menggunakan analisis ragam dan uji tukey digunakan untuk mengetahui perbedaan antar perlakuan. Hasil penelitian menunjukkan bahwa Perlakuan frekuensi pemberian pakan tidak memberikan pengaruh yang nyata terhadap sintasan benih, pertumbuhan panjang dan bobot tubuh benih ikan gabus, Pemberian pakan dengan frekwensi 3 kali sehari menghasilkan sintasan yang tinggi, sementara pertumbuhan panjang spesifik pada pemberian pakan dengan frekuensi 4 kali dan pertumbuhan panjang mutlak pada pemberian pakan dengan frekuensi 5 kali. Pertumbuhan berat spesifik pada pemberian pakan dengan frekwensi 4 kali dan bobot tubuh mutlak pada pemberian pakan dengan frekwensi 4 kali. Parameter kualitas air yang didapatkan selama penelitian tetap mendukung sintasan, pertumbuhan panjang dan pertumbuhan berat benih ikan gabus.
Kondisi Tutupan Karang Perairan Kepulauan Tanakeke Kabupaten Takalar
Authors: Wulandari Sri , Nursyahran Nursyahran , Hidayani Mesalina Tri , Nurwina Nurwina 
Published: November 2022

Terumbu karang mempunyai nilai dan arti yang sangat penting dari segi sosial, ekonomi maupun budaya, pemantauan tutupan terumbu karang penting dilakukan untuk mengetahui tingkat kesehatan ekosistem karang tujuan pengelolaan. Tanakeke merupakan salah satu gugusan kepulauan sebagian besar perairannya dikelilingi oleh ekosistem terumbu karang yang dimanfaatkan oleh nelayan sebagai area Fishing Ground untuk menangkap ikan dan sebagai alur pelayaran transportasi kapal. Namun beberapa penelitian yang telah terpublikasikan sebelumnya lebih fokus pada komunitas ikan di sekitar terumbu karang. Penelitian ini bertujuan untuk mengetahui kondisi tutupan karang dengan menggunakan Metode Point Intercept Transect (PIT), metode ini merupakan salah satu metode yang dikembangkan untuk memantau kondisi karang hidup dengan cara menghitung persen tutupan substrat dasar secara acak. Penelitian ini dilakukan pada Bulan Oktober 2021. Hasil penelitian menunjukkan bahwa ekosistem terumbu karang yang berada di Perairan Kepulauan Tanakeke khususnya di sebelah timur-timur laut, di sebelah barat laut, dan di sebelah timur laut Kecamatan Kepulauan tergolong karang rusak, karang baik, dan karang sedang. Pada stasiun 1, tutupan karang jenis Acropora sebesar 18% dan tutupan karang jenis Non-Acropora sebesar 22%. Pada stasiun 2, tutupan karang jenis Acropora sebesar 70% dan tutupan karang jenis Non-Acropora sebesar 18%. Sedangkan pada stasiun 3, tutupan karang jenis Acropora sebesar 28% dan tutupan karang jenis Non-Acropora sebesar 48%.
Hubungan Kehamilan Kembar dan Polihidramnion dengan Kejadian lilitan Tali Pusat di RSUD H.Abdul Manap Kota Jambi
Authors: Haryanti Dwi , Inayah Wulan 
Published: November 2022

Menurut WHO (World Health Organization) pada tahun 2018 Angka Kematian bayi
(AKB) di dunia yaitu 289 per 100.000 persalinan dengan lilitan tali pusat. Lilitan tali
pusat dikarenakan beberapa faktor salah satunya yaitu kehamilan kembar dan
polihidramnion. Penelitian ini bertujuan untuk mengetahui hubungan kehamilan kembar
dan polihidramnion dengan kejadian lilitan tali pusat.Penelitian ini merupakan rancangan
case control dengan pendekatan retrospektif. Populasi pada peneltian ini adalah semua
ibu bersalin dengan lilitan tali pusat sebanyak 32 responden dan populasi kontrol yaitu
ibu bersalin yang tidak mengalai lilitan tali pusat sebanyak 32 responden dengan teknik
total sampling. Instrumen yang digunakan adalah lembar ceklist. Teknik analisis data
yang digunakan dalam penelitian ini adalah analisis univariat dan bivariat menggunakan
uji Chi-Square.Hasil penelitian menunjukkan bahwa terdapat hubungan antara kehamilan
kembar (p=0,016 & OR=12,13) dan polihidramnion (p=0,000 & OR=7,667) dengan
kejadian lilitan tali pusat di RSUD H.Abdul Manap Kota Jambi Tahun 2022
Faktor-faktor yang berhubungan dengan kejadian rupture perineum pada persalinan normal
Authors: Mariana Silvia , Wati Eka Fajar 
Published: November 2022

Terdapat 2,7 juta kasus rupture perineum di dunia pada ibu bersalin, dimana
angka ini diperkirakan akan mencapai 6,3 juta pada tahun 2050 (Kurniawan, 2020).
Menurut Kemenkes (2018), rupture perineum merupakan penyebab kedua tersering
dari perdarahan pasca persalinan setelah atonia uteri. Rupture perineum merupakan
perlukaan jalan lahir yang terjadi pada saat kelahiran bayi baik menggunakan alat
maupun tidak menggunakan alat. Akibat langsung dari rupture perineum adalah dapat
terjadi perdarahan. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang
berhubungan dengan kejadian rupture perineum pada persalinan normal di PMB
Azimah A.Md.Keb Kota Jambi. Metode penelitian yang digunakan adalah survei
analitik dengan pendekatan retrospektif. Populasi pada penelitian ini adalah ibu
bersalin normal pada bulan Januari sampai Desember tahun 2021 di PMB Azimah
A.Md.Keb yang berjumlah 142 orang. Teknik pengambilan sampel dengan teknik total
sampling 142 orang. Analisa data menggunakan uji Pearson Chi-Square. Hasil
penelitian diperoleh nilai p=0,063 (p > 0,05) untuk umur ibu, p=0,000 (p < 0,05) untuk
paritas, dan p=0,332 (p > 0,05) untuk berat bayi lahir. Kesimpulan penelitian ini adalah
ada hubungan antara paritas dengan kejadian rupture perineum pada persalinan normal
di PMB Azimah A.Md.Keb Kota Jambi dan tidak ada hubungan antara umur ibu dan
berat bayi lahir dengan kejadian rupture perineum pada persalinan normal di PMB
Azimah A.Md.Keb Kota Jambi.
Hubungan Pengetahuan dan Perilaku Menyikat Gigi dengan Status OHI-S Pada Murid Kelas IV SDN 07/IX Kabupaten Muaro Jambi
Authors: Linda Linda , Aida Aida , Sukarsih Sukarsih , Nurutami Nurutami 
Published: November 2022

Berdasarkan Laporan Riset Kesehatan Dasar (Riskesdas) Provinsi Jambi tahun 20131 menunjukkan sebagian besar penduduk umur ≥10 tahun ke atas mempunyai kebiasaan menyikat gigi setiap hari 95,7%, pada waktu mandi pagi 95,8%, dan mandi sore 88,6% dan hanya sedikit yang melakukan sesuai anjuran pada saat setelah makan pagi 4,5% dan sebelum tidur malam 17,8%. Perilaku benar dalam menyikat gigi berkaitan dengan faktor gender, ekonomi dan daerah tempat tinggal, sebagian besar penduduk Indonesia (76,6%) menyikat gigi pada saat mandi pagi maupun mandi sore. Menyikat gigi dengan benar adalah setelah pagi dan sebelum tidur malam, untuk masyarakat Indonesia hanya di temukan 2,3%. Tujuan penelitian yaitu untuk mengetahui hubungan pengetahuan dan perilaku menyikat gigi dengan status OHI-S pada murid kelas IV SDN 07/IX Kabupaten Muaro Jambi.
Desain penelitian : Jenis penelitian menggunakan metode survey analitik dengan rancangan crosssectional. Subjek penelitian sebanyak 32 orang dan berusia 9-11 tahun. Pengumpulan data dengan menggunakan kuesioner meliputi variabel bebas yaitu pengetahuan, perilaku menyikat gigi dan kartu status pemeriksaan meliputi variabel terikat yaitu OHI-S. Data dianalisis dengan uji statistic chi-squere test dan regresi logistik bergambar.
Hasil penelitian bahwa Tidak ada hubungan yang bermakna antara pengetahuan menyikat gigi dengan kebersihan gigi dan mulut pada murid kelas IV SDN 07/IX Kabupaten Muaro Jambi (p Value = 3,670) dan Tidak ada hubungan yang bermakna antara perilaku menyikat gigi dengan kebersihan gigi dan mulut pada murid kelas IV SDN 07/IX Kabupaten Muaro Jambi (p Value = 2,652)
Lipid status, microbiota and bile acids: clinical and pathogenetic relationships
Authors: Успенский Юрий Павлович , Фоминых Юлия Александровна , Наджафова Кямаля Низамитдиновна 
Published: November 2022

Кишечная микробиота - это отдельный уникальный экстракорпоральный орган, выполняющий множество функций в организме человека. Наш метаболизм неразрывно связан с деятельностью представителей кишечной микробиоты. Последнее время большое внимание уделяется изучению роли нормальной микробиоты в липидном обмене, а также роли нарушений микробиоты в формировании и прогрессировании нарушений липидного обмена. В статье приведены современные данные литературы, освещающие указанную тематику, а также результаты исследований, демонстрирующие связи между показателями липидного спектра крови, особенностями микробного пейзажа кишки, и влияние пробиотических штаммов на липидный обмен.
The intestinal microbiota is a separate unique extracorporeal organ that performs many functions in the human organism. Our metabolism is inseparably linked to the activity of representatives of the gut microbiota. Recently, much attention has been paid to the study of the role of normal microbiota in lipid metabolism, as well as to the study of the influence of microbiota disorders on the formation and progression of disorders of lipid metabolism. The article presents current literature data covering this topic. Researches data are also presented that demonstrate the relationship between the blood lipid profile, the characteristics of the microbial landscape of the intestine, and the effect of probiotic strains on lipid metabolism.