bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Driving the Difference in Quality of Recovery Scores Between Scheduled and Unscheduled Cesarean Delivery Patients
Authors: Bhiladvala C. , French-O’Carroll R. , Dadkhah Y. , Bright S. , Chau A. , Seligman K.M. 
Published: November 2022

(Br J Anaesth. 2022;128:e219–e221. doi: 10.1016/j.bja.2021.11.026)
Patients undergoing unscheduled cesarean deliveries (CDs) are shown to have worse Obstetric Quality of Recovery Scores (ObsQoR-11) than those undergoing scheduled CDs. This quality improvement study investigated the causes behind this difference in scores.
Defining the Decision-to-Delivery Interval at Cesarean Section: Narrative Literature Review and Proposal for Standardization
Authors: May R.L. , Clayton M.A. , Richardson A.L. , Kinsella S.M. , Khalil A. , Lucas D.N. 
Published: November 2022

(Anaesthesia. 2022;77:96–104. doi: 10.1111/anae.15570)
The 30-minute decision-delivery interval for emergency cesarean delivery (CD) is a deeply embedded and widely studied standard for the evaluation of outcomes in high-resource settings. Despite the self-evident nature of the term, there is no consensus for what specifically defines the instance of “decision,” “delivery,” “incision,” or other timepoints related to carrying out the surgery. This review investigates how these terms have been used in publications in the preceding 40 years, and how inconsistent approaches may undermine the utility of this framework.
Varying Dosages of Subcutaneous Unfractionated Heparin and Activated Partial Thromboplastin Time in Hospitalized Antepartum Patients: A Retrospective Cohort Analysis
Authors: Elmofty D.H. , Tucker A. , Wuenstel A.M. , Cheng P.K. , Fox E. , Knoebel R. , Liao C. , Scavone B. 
Published: November 2022

(Anesth Analg. 2022;134:1028–1034. doi: 10.1213/ANE.0000000000005866)
Approximately 10% of all maternal deaths in the United States are from venous thromboembolism (VTE). Clinical guidelines have been put into place, including what to administer antepartum patients with history of VTE who require an empiric pharmacologic prophylaxis. The recommended dosage for subcutaneous unfractionated heparin (UFH) corresponds to gestational age: 5000 to 7500 units every 12 hours for first trimester, 7500 to 10,000 units every 12 hours for second trimester, and 10,000 units every 12 hours for third trimester antepartum patients. The increased dosage is due to changing distribution volume, bioavailability, clearance, and metabolism during pregnancy. These clinical guideline adjustments may impact anesthetic use during labor and cesarean delivery, as UFH potentially inhibits coagulation, increases activated partial thromboplastin time (aPTT), and subsequently increases the risk of neuraxial hematoma associated with neuraxial anesthesia. The primary aim of this study was to determine the effect UFH has on coagulation by assessing what proportion of hospitalized antepartum women with aPTT over 40 seconds following subcutaneous UFH. The secondary aim was to identify the association between aPTT over 40 seconds and other risk factors.
In-Hospital Opioid Consumption After the Previous Cesarean Delivery Weakly Predicts Opioid Consumption After Index Delivery: A Retrospective Cohort Study
Authors: Komatsu R. , Nash M. , Mandalia S. , Dinges E. , Kamal U. , Singh D. , El-Omrani H. , Anwar A. , Delgado C. , Ziga T.M. , Carvalho B. 
Published: November 2022

(Anesth Analg. 2022;134:1280–1287. doi: 10.1213/ANE.0000000000005918)
Opioid administration is a common form of analgesia for breakthrough pain following cesarean deliveries (CDs) when nonopioid medication is not sufficient. Pain severity can differ from patient to patient, so an individualized approach to care can be taken. Predicting in-hospital opioid consumption following a repeat CD has not been previously studied. The primary aim is to identify if prior opioid consumption 48 hours postoperatively following CD correlates with patient opioid consumption following index CD. The primary aim of the investigations was that an associated prediction would exist. Secondary aims included whether pain scores correlated and if obstetric and demographic variable improved prediction accuracy.
The Combination of the Mini-Punch Technique and Photodynamic Therapy for the Treatment of Mandibular Keloids and Hypertrophic Scars
Authors: Luo Xian Yan , Wu Xin Gang , Xu Ai E. , Song Xiu Zu , Peng Jian Zhong 
Published: November 2022

BACKGROUND
Mandibular keloids and hypertrophic scars can exert significant effects on the appearance of a patient. However, current treatments are not effective in all cases. Consequently, it is vital to identify a safe and effective treatment method.

OBJECTIVE
To investigate the therapeutic effect of the mini-punch technique combined with photodynamic therapy (PDT) on mandibular keloids and hypertrophic scars.

PATIENTS AND METHODS
Twenty patients with mandibular keloids and hypertrophic scars were enrolled, including 5 cases of keloids and 15 cases of hypertrophic scars, with a total of 40 lesions. The mini-punch technique was performed first, and then, PDT was conducted, once a week on 3 occasions in total.

RESULTS
After 12 months of follow-up, 30 lesions had improved by more than 50%, thus achieving a good therapeutic effect. The Vancouver Scar Scale score of patients ranged between 8 and 12 points with a mean of 9.60 ± 1.09 points before surgery and between 2 and 9 points with a mean of 4.15 ± 2.05 points at 12 months after surgery. The mean Vancouver Scar Scale score after treatment was significantly lower than that before treatment (t = 11.80, p < .001).

CONCLUSION
A combination of the mini-punch technique and PDT is an effective treatment for mandibular keloids and hypertrophic scars.
Social Media in Aesthetic Dermatology: Analysis of the Users Behind the Top Filler Posts
Authors: Richey Patricia M. , Hashemi David A. , Avram Mathew M. 
Published: November 2022

BACKGROUND
Within the aesthetic realm, the influence of social media is quite prominent, with a growing percentage of patients using this technology to seek out health care recommendations and education.

OBJECTIVE
To ascertain the most accurate representation of what our patients may encounter on social media, we sought to characterize the top posts on the most popular visually-based social media platform (Instagram).

MATERIALS AND METHODS
We queried Instagram with variations of hashtags related to filler to determine which hashtags had the greatest number of posts associated with them. We then reviewed the top 100 posts associated with the top 9 hashtags, making note of whether the poster was a physician or nonphysician and whether an off-label procedure was performed or discussed.

RESULTS
Most (85.6%) of the 900 reviewed posts were written by nonphysicians, and most (84.6%) of the posts focused on off-label procedures were posted by nonphysicians. Among the physician posters, the most common specialties were Plastic Surgery and Family Medicine, followed by Dermatology.

CONCLUSION
At a time when patients are increasingly turning to social media for health care recommendations and education, most “top” content related to soft tissue augmentation is being provided by nonphysicians, many of whom are performing off-label procedures.
Comparison of corneal biomechanical properties in healthy thin corneas with matched keratoconus eyes
Authors: Sedaghat Mohammad-Reza , Momeni-Moghaddam Hamed , Ehsaei Asieh , Vinciguerra Riccardo , Zamani Omid , Robabi Hassan 
Published: November 2022

Purpose:
To compare corneal biomechanical parameters of normal thin corneas with matched keratoconus eyes.

Setting:
Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Design:
Cross-sectional comparative study.

Methods:
Dynamic corneal response parameters of Corvis ST were compared in 61 eyes with keratoconus with 61 matched healthy thin corneas (corneal thinnest point <500 μm), while corneal thickness, biomechanically corrected intraocular pressure, and age were considered covariates. The receiving operator sensitivity curve analysis was used to determine the cutoff point with the highest sensitivity and specificity, and the area under the curve (AUC) for each parameter.

Results:
All biomechanical parameters were statistically significant between the 2 groups except for the first (P = .947) and second (P = .582) applanation length, first (P = .783) and second (P = .301) applanation velocity, and deformation amplitude in the highest concavity phase (P = .106). The highest mean difference between groups (12.89 ± 2.03 mm Hg/mm) was related to the stiffness parameter at the first applanation (SPA1). Although the Corvis biomechanical index and tomographic biomechanical index had the highest detection ability based on their AUC (0.912 and 0.959, respectively), among the standard and combined biomechanical parameters except for keratoconus screening parameters, the highest discriminative ability was related to SPA1 with AUC, sensitivity, and specificity of 0.793, 60.66%, and 90.16%, respectively.

Conclusions:
Keratoconus corneas were significantly softer compared with healthy thin corneas of matched thickness. Optimal cutoff points close to the maximum value defined for screening parameters limit their clinical use for differentiation purposes in these particular types of cases.
Patterns of patient outcomes following specialist pain management in Australasia: a latent class analysis using the electronic Persistent Pain Outcomes Collaboration database
Authors: Tardif Hilarie , Allingham Samuel F. , Rahman Mijanur , Daly Anne 
Published: November 2022

Abstract
The increasing demand for pain management and limited resources available highlight the need to measure treatment effectiveness. We analysed data collected at 75 specialist persistent pain services located in Australia and New Zealand to calculate the overall treatment outcome for patients receiving care during 2014 to 2020. Sociodemographic and clinical information was provided for 23,915 patients, along with patient-reported measures assessing pain, pain interference, depression, anxiety, stress, pain catastrophizing, and pain self-efficacy. Latent class analysis identified 4 distinct outcomes based on patients' pattern of responses across the assessment tools at treatment end. Group 1 (n = 8369, 35%) reported low/mild severity across all clinical domains at the end of care, while group 4 (n= 7081, 30%) were more likely to report moderate/high severity on all domains. Group 2 (n = 1991, 8%) reported low/mild pain with moderate/high psychological distress at treatment end, and group 3 (n = 6474, 27%) reported moderate/high pain with low/mild psychological distress. Multivariable logistic regression identified those factors associated with the different groups. In particular, factors most predictive of a poor (group 4) vs good outcome (group 1) were unemployment (due to pain or other reasons), requiring an interpreter, widespread pain, pain of longer duration, and attributing the pain to an injury at work. The results may allow identification of those most likely to benefit from the services currently provided and inform development of alternative or enhanced services for those at risk of a poor outcome.
The links between adipose tissue DNA methylation, obesity, and insulin resistance: A protocol for systematic review
Authors: Li Suwen , Wang Yan , Li Zinan , Long Cong , Zhou Qian , Chen Qiu 
Published: November 2022

Background and rationale:
Obesity is a metabolic condition brought on by the interplay of hereditary and environmental factors, making it one of the most common diseases in the world. Insulin resistance (IR) and obesity have a close connection and can both be advantageous. One of the main methods of epigenetic regulation is DNA methylation modification. Studies have demonstrated over the past few years that DNA methylation is crucial to the emergence of obesity and DNA methylation can lead to IR. Adipose tissue participates in the physiopathological processes of obesity and IR and functions as an endocrine organ controlling the body’s balanced metabolism, thus, adipose tissue-associated gene DNA methylation affects the development of obesity and IR by influencing the function of adipose tissue. Hence, an explanation of current research on DNA methylation, IR, and obesity, following the most recent developments, exploring changes in DNA methylation in different types of adipose tissue in insulin-resistant patients and obese patients may enable the identification of novel targets in clinical obesity prevention and treatment.

Method and analysis:
The following electronic bibliographic databases will be searched from inception for peer-reviewed original research published: MEDLINE (through PubMed), Scopus, and EMBASE. Cochrane Library, Cochrane Clinical Trials Registry, the National Institutes for Health Clinical Trials Registry, and the WHO International Clinical Trials Registry Platform from inception to December 31, 2021 will be conducted. Systematic reviews will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines. The development of search strategies will make use of medical issue phrases and keywords associated with DNA methylation, Adipose tissue DNA methylation, obesity, and IR. Identified citations will be independently reviewed by two authors to determine eligibility at the title and abstract level, and then at the full text and data extraction phases. Disagreements and conflicts will be resolved through discussion with a third author. Two authors will extract the necessary data from the included studies independently, and The Cochrane Risk of Bias Assessment Tool will be used to assess the bias of randomized controlled studies, and the Newcastle–Ottawa scale for nonrandomized controlled studies. If the interventions and outcomes evaluated are sufficiently homogeneous, results from subgroups of studies will be pooled together in a meta-analysis.
The efficacy and safety of traditional Chinese medicine treating diabetic cardiomyopathy: A protocol for systematic review and meta-analysis
Authors: Han Shuo , Hou Yuan , Liu Huaman , Zhao Quanlin 
Published: November 2022

Background:
Diabetic cardiomyopathy, secondary to diabetes, is the main cause of death in patients with diabetes. In China, traditional Chinese medicine has achieved good performance in treating diabetic cardiomyopathy. However, to date, no systematic review or meta-analysis has been published on the treatment of diabetic cardiomyopathy by traditional Chinese medicine.

Methods:
This study strictly followed the preferred guidelines for systematic review. Two researchers searched seven databases: EMbase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journal Database, and WANFANG Database. The retrieval time limit ranged from the establishment of the database to August 2022. All clinical randomized controlled trials that met the inclusion and exclusion criteria were included in this study. Statistical analysis was performed using RevMan 5.3.

Results:
This study analyzed the clinical efficacy and safety of traditional Chinese medicine in the treatment of diabetic cardiomyopathy.

Conclusion:
The results of this study provide evidence-based medical evidence for the clinical use of traditional Chinese medicine in the treatment of diabetic heart disease in the future.
A case report of secondary parathyroid adenomatous hyperplasia with carcinoma
Authors: Chen Simei , Sui Xin , Zhao Bingxin , Liu Zongjie , Dai Xinpeng , Ding Yang 
Published: November 2022

Introduction:
Secondary parathyroid hyperplasia canceration is very rare and thus easily be overlooked during parathyroid ultrasound examination. However, secondary parathyroid hyperplasia still has the possibility of canceration, and it is still important to be alert to its occurrence when performing ultrasound examinations and clinical treatment.

Patient concerns:
A 49-years-old man visited our outpatient department with generalized weakness and pain in both lower extremities a month ago.

Diagnosis:
Hyperparathyroidism secondary to chronic renal failure.

Interventions:
The patient underwent ultrasound and other preoperative examinations. The preoperative ultrasound showed 3 parathyroid enlargements, 2 on the left and 1 on the right. The patient then underwent surgical treatment.

Outcomes:
Ultrasonography suggested the presence of 3 parathyroid hyperplasias, and ectopic right inferior parathyroid gland was visible during intraoperative examination. 10 days after surgery, the patient’s Parathyroid Hormone returned to the normal range.

Conclusion:
Secondary parathyroid hyperplasia has the potential to become cancerous, so doctors should be alert to its occurrence when conducting ultrasound examinations. Ultrasound examination is the key to its diagnosis and subsequent treatment.
Refractory psychiatric symptoms and seizure associated with Dandy-Walker syndrome: A case report and literature review
Authors: Chen Yijing , Zhu Junhong , Zhang Di , Han Li , Wang Juan , Yang Weiwei 
Published: November 2022

Backgrounds:
Dandy-Walker syndrome (DWS) is a group of brain malformations which occasionally accompanied by psychotic symptoms. The co-occurrence of DWS and epilepsy in children is quite rare.

Case description:
We reported a 14-year-old male who presented with a 8-month history of inconsistent upper limb tremor and accidental seizure. The MRI showed the typical alterations of DWS: cystic dilatation of the fourth ventricle, vermian hypoplasia, enlarged posterior fossa. He received the ventriculoperitoneal shunting (VPS) placement for hydrocephalus and had a symptom-free period for 8 days. Then he experienced a recurrence of involuntary upper limb tremor and behavior disturbance after decreasing the pressure of cerebrospinal fluid (CSF) from 150 to 130 mm Hg. After being treated with Olanzapine 10 mg/d, Clonazepam 3 mg/qn and Valproate acid (VPA) 500 mg/bid for nearly a month, his mental status and psychotic symptoms fluctuated. A search of Pub Med showed little report of hydrocephalus and DWS comorbidity with seizure and psychosis. Here we presented the whole process of a rare disease from the very beginning with all his symptoms, examinations and treatments.

Conclusion:
VPS placement surgery at an earlier stage may be an effective way to avoid inevitable brain damage so as to improve the clinical outcomes for patients with DWS. Continued treatment with regard to DWS condition may include shunt placement, but it mainly focus on developmental concerns, with occupational and physical therapy along with ongoing supportive psychotherapy to improve the coping skills and quality of life.
Telenursing in the sexual function of women with breast cancer: A study protocol
Authors: Silva Ferreira Iarlla , Carvalho Fernandes Ana Fátima , Moura Barbosa Castro Régia Christina , Rodrigues Bezerra Andrea , Velasco Yanez Romel Jonathan 
Published: November 2022

Introduction:
Most women with breast cancer have sexual function problems related to cancer diagnosis and treatment. These problems harm the quality of life and relationships. However, most patients do not receive care or guidance regarding sexuality from healthcare providers. This study aimed to test the effect of telenursing counseling on sexual functioning in women undergoing breast cancer treatment.

Methods:
This randomized clinical trial was conducted at 2 reference hospitals for cancer treatment. One hundred eight women with stage I–IV breast cancer undergoing treatment (surgery, chemotherapy, radiotherapy or hormone therapy) with a partner will be included in this study. The study was authorized by the Ethics Committee of the Federal University of Ceará (Opinion number: 46,13,609) and the Maternity School Assis Chateaubriand (Opinion number: 47,42,687). Patients will be allocated to the following groups: the control group, which will not receive an active intervention, and the intervention group, which will receive 3 telenursing counseling sessions for 6 weeks. The levels of sexual function in these patients before the intervention, soon after the intervention and at 12 weeks were compared and analyzed. All data will be collected and analyzed by the JASP program.

Results:
Differences in levels of sexual function among women allocated to the control and intervention groups in the analyzed periods.

Conclusion:
This evidence-based nursing care strategy can be used to improve the sexual function of breast cancer patients and consequently their quality of life and marital relationship.
Efficacy of traditional Chinese exercises in patients with post-COVID-19 chronic fatigue syndrome: A protocol for systematic review and meta-analysis
Authors: Liu Zhen , Lv Zhizhen , Zhou Xingchen , Shi Jiao , Hong Shuangwei , Huang Huazhi , Lv Lijiang 
Published: November 2022

Background:
Some patients develop long-term symptoms after Corona virus disease 2019 (COVID-19), and chronic fatigue syndrome (CFS) is one of the main symptoms. CFS is characterized by fatigue lasting for more than 6 months accompanied by sleep disorders, anxiety, and depression, which causes a certain degree of harm to both physiological and psychological aspects of the individual. Traditional Chinese exercises (TCEs) are an ancient Chinese therapy and has recently been reported to be effective for CFS. Therefore, we will conduct a systematic review and meta-analysis aiming to accurately evaluate the efficacy of TCEs on post-COVID-19 CFS and provide an alternative treatment for post-COVID-19 CFS.

Methods:
Seven databases (PubMed, Ovid Embase, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), and Wanfang) will be searched from establishment to August 2022, and we will only include randomized controlled trials of TCEs for post-COVID-19 CFS. Two reviews will independently include the research according to the inclusion and exclusion criteria. Review Manager 5.2 software will be used to analyze the accepted literature, and the relative risk ratio (RR) and 95% confidence interval (CI) will be used as effect indicators for the outcome indicator dichotomous variables. For continuous variables, weighted mean difference (MD) and 95% CI will be used as effect indicators. The heterogeneity test will be assessed using the I
2 statistic and Q statistic. The PEDro scale was used to evaluate the methodological quality of the included studies. Subgroup analysis was performed according to different TCEs, age, gender, and duration of CFS.

Results:
This systematic review and meta-analysis will evaluate the efficacy of TCEs in post-COVID-19 CFS.

Conclusion:
The results of this study will provide reliable evidence for the effects of TCEs for post-COVID-19 CFS on patients’ fatigue, anxiety, depression, sleep, and quality of life.