bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Diagnostic Values of Trans-vaginal Three-dimensional Ultrasound Parameters RI, PI, and Serum TSGF on Ovarian Space Occupying Lesions
Authors: Liu Tianying , Duan Xin 
Published: December 2022

Abstract

Objective: To diagnose ovarian space occupying lesions by trans-vaginal three-dimensional ultrasound parameters, RI, PI, and serum TSGF, then analyze and study their clinical diagnostic values.
Methods: 40 cases of patients with ovarian space occupying lesions, treated in our hospital from May, 2021 to May, 2022, including 20 cases in early stage (the Control Group) and 20 cases in middle stage (the Observation Group), were examined by trans-vaginal three-dimensional ultrasound parameters, RI, PI and serum TSGF, to analyze the diagnostic values.
Results: (1) In Observation Group, 9 cases of patients with ovarian space occupying lesions were mainly diagnosed as malignant ovarian tumors, accounting for 45.00%; In Control Group, 14 cases of patients with ovarian space occupying lesions were mainly diagnosed as benign ovarian tumors, accounting for 70.00%; (2) The index level of serum TSGF (86.79±7.95U/ml VS 65.94±9.46U/ml) in ovarian space occupying lesions in the Observation Group was higher while PI (1.21±0.16mmol/L VS 2.34±0.06mmol/L) and RI (0.68±0.03mmol/L VS 0.76± 0.06 mmol/L) were lower (p<0.05) compared with the Control Group; (3) The index levels of CA125 (346.83±153.73RU/L VS 39.94±16.54RU/L) and CEA (36.25±17.08μg/L VS 17.46±4.72μg/L) in the Observation Group were higher than those in the Control Group(p<0.05); (4) The ADC means of the cystic portion (2752.39 ± 87.49vs3719.68 ± 84.76) and the solid portion (884.47 ± 71.98vs989.47 ± 76.79) in the Observation Group were lower than those in the Control Group (p<0.05).
Conclusion: The diagnosis of ovarian space occupying lesions by trans-vaginal three-dimensional ultrasound parameters RI, PI and serum TSGF, could significantly increase the clinical value and accuracy for the diagnosis of ovarian space occupying lesions. Early diagnosis and treatment were of great significance, and shall be recommended and available in clinical practice.
The mediational role of interoceptive awareness on the improvements of mindfulness skills of workers
Authors: González-Palau Fátima , Medrano Leonardo Adrián 
Published: December 2022

Abstract
Background: Mindfulness training has been introduced in numerous health care programs and also in work settings with promising results. One main point in intervention studies of mindfulness is the evaluation of the mechanisms of action that explains how and why mindfulness based interventions (MBIs) works. The present study aims to assess the mediational role of interoceptive consciousness on the improvements of mindfulness skills.
Methods: Seventy-four adults between 23 and 64 years of age participated in the study. We carried out one effectiveness analysis comparing the means of Multidimensional Assessment of Interoceptive Awareness scale, Five Facet Mindfulness Questionnaire, Mindful Attention Awareness Scale scores in the two conditions (pretest – posttest). Subsequently, within-subjects effect sizes (pre-to-post-treatment) were calculated and we conducted multiple mediation analyses to examine whether the changes between pre and post-treatment of Mindful Attention Awareness Scale and Five Facet Mindfulness Questionnaire scores were mediated by changes of interoception awareness.
Results: The results indicate that the mindfulness-based intervention generates statistically significant changes in the Mindful Attention Awareness Scale scores and in all the Five Facet Mindfulness Questionnaire dimensions, with the exception of the Describe and Not Reaction subscales. The mediation analyses showed that interoceptive awareness significantly mediated the improvements of mindfulness skills after the program.
Conclusions: Findings support the idea that meditation practice leads to increase in interoception awareness, which in turn facilitates mindfulness skills and consequently well-being.
Novel Chaotic Image Cryptosystem Using Dynamic DNA Coding
Authors: Zhou Shuang , Wei Yi , Zhang Yingqian , Teng Lin 
Published: December 2022

Abstract

To solve the problem of a small key space of image cryptosystem based on logistic, this paper presents a new 1D chaotic map with a wider and continuous chaotic range, much larger Lyapunov exponent and more complex behavior. Using the proposed one-dimensional chaotic map, an image cryptography algorithm is developed. In this paper, a novel image cryptosystem based on the proposed map and dynamic DNA encoding is designed, which is different from other DNA encoding method. Our method is based on chaotic sequences to obtain complex DNA sequence, and it is calculated with our plaintext image DNA sequence, which not only plays a good encryption effect. Moreover, our dynamic DNA coding process is simple, easy to operate and implement with good effect. Experimental results presented that compared with the fixed DNA and some recent chaos-based image encryption schemes, the proposed cryptosystem has higher security.
Distance learning and face-to-face learning in medical PBL course during COVID-19 pandemic: an investigation and teaching experience in Taiwan
Authors: Chen Fang Hsu , Wu Bo-Ren , Chi Chin-Hsien 
Published: December 2022

Abstract
To prevent the infection and outbreak of COVID-19, the education method has adjusted the conventional in-person classes to distance learning in recent two years. Most classes were lectures that could go well if the participants were familiar with the online operation and had a stable network environment. Nevertheless, classes such as problem-based learning (PBL) rely on plenty of discussions and still have some limitations for communication and group development. In this research, we surveyed the learning effects of face-to-face (FF) and distance learning (DL) in the medical PBL course at Cheng-Kung University for two individual classes. Tutors and students were requested to give grades for the five key areas (participation, communication, preparation, critical thinking, and group skill). Five factors are used to evaluate the learning effect of face-to-face and distance learning. Compared with FF and DL methods, our research clarified that student learning effects would reduce participation, communication, and group skills by questionnaire survey. The tutors’ perspective regarded participation and communication ability as reduced at distance learning. But for group skills, one of the two classes showed no difference. Our research provides an experience for the PBL class focusing on discussion and communication. In the post-pandemic era, whether face-to-face or distance learning, classes should be adjusted properly to let students conduct effective communication in time.
Personalized Colorectal Cancer Screening: Study Protocol of a Mixed-methods Study on the Effectiveness of Tailored Intervals Based on Prior F-hb Concentration in a Fit-based Colorectal Cancer Screening Program
Authors: Breekveldt Emilie C. H. , Toes-Zoutendijk Esther , de Jonge Lucie , Spaander Manon C. W. , Dekker Evelien , Kemenade Folkert J. van , Vuuren Anneke J. van , Ramakers Christian R. B. , Nagtegaal Iris D. , Leerdam Monique E. van , Lansdorp-Vogelaar Iris 
Published: December 2022

Abstract
Background: In 2014, the national population-based colorectal cancer (CRC) screening program was implemented in the Netherlands. Biennial fecal immunochemical testing (FIT) for hemoglobin is used at a cut-off of 47 microgram hemoglobin per gram feces. The CRC screening program successfully started, with high participation rates and yield of screening. Now that the program has reached a steady state, there is potential to further optimize the program. Previous studies showed that prior fecal Hb (f-Hb) concentrations just below the FIT cut-off are associated with a higher risk for detection of advanced neoplasia (AN) at subsequent screening rounds. We aim to achieve a better balance between the harms and benefits of CRC screening by offering participants tailored invitation intervals based on prior f-Hb concentrations after negative FIT.
Methods: This mixed-methods study will be performed within the Dutch national CRC screening program and will consist of: 1) a randomized controlled trial (RCT), 2) focus group studies, and 3) decision modelling. The primary outcome is the yield of AN per screened individual in personalized screening vs. uniform screening. Secondary outcomes are perspectives on, acceptability of and adherence to personalized screening, as well as long-term outcomes of personalized vs. uniform screening. The RCT will include 20,000 participants of the Dutch CRC screening program; 10,000 in the intervention and 10,000 in the control arm. The intervention arm will receive a personalized screening interval based on the prior f-Hb concentration (1, 2 or 3 years). The control arm will receive a screening interval according to current practice (2 years). The focus group studies are designed to understand individuals’ perspectives on and acceptability of personalized CRC screening. Results of the RCT will be incorporated into the MISCAN-Colon model to determine long-term benefits, harms, and costs of personalized versus uniform CRC screening.
Discussion: The aim of this study is to evaluate the yield, feasibility, acceptability and (cost-) effectiveness of personalized CRC screening through tailored invitation intervals based on prior f-Hb concentrations. This knowledge may be of guidance for health policy makers and may provide evidence for implementing personalized CRC screening in The Netherlands and/or other countries using FIT as screening modality.
Trial registration: Clinical Trials, NCT05423886, June 21, 2022, https://clinicaltrials.gov/ct2/show/NCT05423886
Effects of post-transplant maintenance therapy with decitabine prophylaxis on the relapse for acute lymphoblastic leukemia.
Authors: Guo Rong , Fan Jixin , Zhu Jingkui , Guo Xiao , Wan Ding-Ming , Xie Xinsheng , Cao Weijie , Lu Run-Qing , Zhang Yinyin , Zhao Haiqiu , Li Yingmei , Guo Rongqun , Jiang Zhongxing , Song Yong-Ping , He Fei 
Published: December 2022

Abstract
In adults with acute lymphoblastic leukemia (ALL), post-transplant relapse is a major risk factor for mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our study investigated the efficacy and safety of decitabine (dec) with ALL patients post-transplantation. We performed a retrospective cohort study to assess the efficacy of decitabine (dec) with post-transplant ALL at the First Affiliated Hospital of Zhengzhou University from February 2016 to September 2021. A total of 141 consecutive ALL patients were analyzed and divided into decitabine (dec, n = 65) and control (ctrl, n = 76) groups based on whether they were treated with decitabine after allo-HSCT. The 3-year cumulative incidence of relapse (CIR) rate in the dec group was lower than that in the ctrl group (19.6% vs. 36.1%, p = 0.031), with a hazard ratio of 0.491 (95% confidence interval [CI], 0.257–0.936). Additionally, subgroup analyses revealed that the 3-year CIR rate of T-ALL and Ph-negative B-ALL patients in the dec and ctrl groups was 11.7% vs. 35.9% and 19.5% vs. 42.2% (p = 0.035, p = 0.068) respectively. In summary, ALL patients, especially those with T-ALL and Ph-negative B-ALL, may benefit from decitabine as maintenance therapy following allo-HSCT.
Spatio-temporal evolution and driving forces of habitat quality in Guizhou Province
Authors: Xie Bo , Zhang Mingming 
Published: December 2022

Abstract
This study aimed to analyze spatio-temporal changes in habitat quality in Guizhou Province during the 1990–2018 period and identify factors influencing habitat quality. Land-use data for the period were used to evaluate spatio-temporal variations in habitat quality using the InVEST model, and factors influencing habitat quality were analyzed using GeoDetector. According to the results, cultivated land and forestland decreased by 0.48% and 0.88%, respectively, during the study period. Grassland, water, and construction land areas increased, with construction land increasing the most (0.92%) followed by water area (0.37%). The main land-use changes included conversion of cultivated land to forestland, grassland, and construction land. The average habitat quality index for Guizhou Province changed from 0.633 to 0.627 over the 1990–2018 period, showing an overall downward trend. The distribution pattern of habitat quality was spatially "high in the north, south, and, east, and low in the west". High habitat quality areas were mainly located in the western part of Guizhou Province, whereas low habitat quality areas were located in the central region. Land-use was the major factor influencing the spatio-temporal variations in habitat quality, and the interactive effect between any two factors was stronger than that of a single factor. Natural factors and human factors co-dominate the temporal-spatial changes of habitat quality.
Brief exposure to enriched environment rapidly shapes the glutamate synapse in the rat brain: a metaplastic fingerprint
Authors: Pintori Nicholas , Piva Alessandro , Mottarlini Francesca , Díaz Fernando Castillo , Maggi Coralie , Caffino Lucia , Fumagalli Fabio , Chiamulera Cristiano 
Published: December 2022

Abstract
Environmental enrichment (EE) has been shown to produce beneficial effects in addiction disorders; however, due to its complexity, the underling mechanisms are not yet fully elucidated. Recent evidence suggests that EE, acting as a metaplastic agent, may affect glutamatergic mechanisms underlying appetitive memory and in turn, modulate reward-seeking behaviors. Here, we explore the hypothetical metaplastic effects induced by brief EE exposure on glutamatergic transmission in brain areas involved in rewarding and memory processes. Adult male Sprague-Dawley rats were exposed to EE for 22h and the expression of critical elements of the glutamate synapse were measured 2h after the end of EE in medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and hippocampus (Hipp). We focused our attention on the expression of NMDA and AMPA receptor subunits, their scaffolding proteins SAP102 and SAP97, vesicular and membrane glutamate transporters vGluT1 and GLT-1, and critical structural components such as proteins involved in morphology and function of glutamatergic synapses, PSD95 and Arc/Arg3.1. Our findings demonstrate that a brief EE exposure induces metaplastic changes on glutamatergic mPFC-NAc-Hipp brain areas, which are critical for reward and learning processes. Such changes were area-specific and involved a rearrangement of postsynaptic NMDA/AMPA receptor subunit composition, as well as changes in the expression of their main scaffolding proteins thus influencing the retention of such receptors at synaptic sites. Our data indicate that brief EE exposure is sufficient to cause metaplastic activity at glutamatergic synapses in mPFC-NAc-Hipp circuits, which may modulate several mental processes such as rewarding, learning and memory processes.
Removal of evolutionarily conserved functional MYC domains in a tilapia cell line using a vector-based CRISPR/Cas9 system
Authors: Kim Chanhee , Cnaani Avner , Kültz Dietmar 
Published: December 2022

Abstract
MYC transcription factors have critical roles in facilitating a variety of cellular functions that have been highly conserved among species during evolution. However, despite circumstantial evidence for an involvement of MYC in animal osmoregulation, mechanistic links between MYC function and osmoregulation are missing. Mozambique tilapia (Oreochromis mossambicus) represents an excellent model system to study these links because it is highly euryhaline and highly tolerant to osmotic (salinity) stress at both the whole organism and cellular levels of biological organization. Here, we utilize an O. mossambicus brain cell line (OmB cells) and an optimized vector-based CRISPR/Cas9 system to functionally knockout MYC in the tilapia genome and to establish causal links between MYC and cell function, including cellular osmoregulation. A cell isolation and dilution strategy yielded polyclonal MYC (myca) knockout cell pools with low genetic variability and high gene editing efficiencies (as high as 98.2 %). Further isolation and dilution of cells from these pools yielded a monoclonal myca ko cell line harboring a 1-bp deletion that caused a frameshift mutation. This frameshift functionally inactivated the transcriptional regulatory and DNA-binding domains predicted by bioinformatics and structural analyses. Both the polyclonal and monoclonal myca ko cell lines were viable, propagated well in standard medium, and differed from wild-type cells in morphology. As such, they represent a new tool for causally linking myca to cellular osmoregulation and other cell functions.
Deletion and Recovery Scheme of Electronic Health Records Based on Medical Certifificate Blockchain
Authors: Wang Baowei , Wang Neng , Zhang Yuxiao , Xu Zenghui , Zhang Junhao 
Published: December 2022

Abstract
The trusted sharing of Electronic Health Records (EHR) can realize the effiffifficient use of medical data resources. Generally speaking, EHR are stored inside the hospital, but their ownership is the patient, So every patient has the right to delete their own EHR stored in the hospital. However, after the deletion, it is diffiffifficult for the patient to have a record to share when he visits the hospital again. To solve this problem, we use the Medical Certifificate Blockchain and InterPlanetary File System (IPFS) to store Personal Health Records, which are generated by patients in difffferent medical institutions. We use cross-chain technology to interconnect the Medical Certifificate Blockchain and the Hospital blockchain to enable the recovery of deleted Electronic Health Record. In addition, We also combine digital watermarking technology to ensure the authenticity of the restored Electronic Health Record. System analysis and security analysis illustrate the completeness and feasibility of the scheme.
IRIS: Integrated Retinal Functionality in Image Sensors
Authors: Yin Zihan , Kaiser Md , Camara Lamine , Camarena Mark , Parsa Maryam , Jacob Ajey , Schwartz Gregory , Jaiswal Akhilesh 
Published: December 2022

Abstract
Neuromorphic image sensors draw inspiration from the biological retina to implement visual computations in electronic hardware. Gain control in phototransduction and temporal differentiation at the first retinal synapse inspired the first generation of neuromorphic sensors, but processing in downstream retinal circuits, much of which has been discovered in the past decade, has not been implemented in image sensor technology. We present a technology-circuit co-design solution that implements two motion computations occurring at the output of the retina that could have wide applications for vision based decision making in dynamic environments. Our simulations on Globalfoundries 22nm technology node show that, by taking advantage of the recent advances in semiconductor chip stacking technology, the proposed retina-inspired circuits can be fabricated on image sensing platforms in existing semiconductor foundries. Integrated Retinal Functionality in Image Sensors (IRIS) technology could drive advances in machine vision applications that demand robust, high-speed, energy-efficient and low-bandwidth real-time decision making.
Individual need and health system factors associated with cervical cancer screening uptake among women of child-bearing age in Mangochi district, Malawi: a facility-based cross-sectional study
Authors: Mpachika-Mfipa Felistas , Kululanga² Lucy Ida , Mfipa Dumisani , Kazembe Abigail 
Published: December 2022

Abstract
Background
Cervical cancer screening (CCS) uptake remains low in poor countries. Limited studies have assessed individual need and health system factors which facilitate/impede use of healthcare services, including CCS uptake. Thus, we examined associations between these factors and CCS uptake among women of child-bearing age (WCBA) in Mangochi, Malawi.
Methods
A cross-sectional study, sampling 482 women (18–49 years) using a multi-stage sampling method was conducted in five health facilities (HFs). Data were collected from June-July, 2019. Chi-squared or Fisher’s exact tests were used to compare the distribution of CCS uptake according to different independent groups.
Results
The proportion of WCBA who did CCS was significantly higher among HIV + women than those who were HIV- and with unknown HIV status, respectively [27.3% (33/121) vs 8.5% (30/353) vs 0% (0/8), χ2 = 29.18, df = 2, p < 0.001]. Significantly higher among those who had ever heard of cervical cancer (CC) than those who had not [23.0% (60/261) vs 1.4% (3/221), χ2 = 49.28, df = 1, p < 0.001]. Significantly higher among those who heard of CC from HFs than those who heard through radios, friends/family and other sources, respectively [31.2% (44/141) vs 16.7% (7/42) vs 9.3% (5/54) vs 16.7% (4/24), χ2 = 12.62, df = 3, p = 0.006]. Significantly higher among those with positive beliefs towards CCS than those with negative beliefs [19.2% (53/276) vs 4.9% (10/206), χ2 = 21.37, df = 1 p < 0.001]. Significantly higher among those recommended for CCS by health workers (HWs) than those not recommended [19.6% (53/270) vs 4.7% (10/212), χ2 = 23.24, df = 1, p < 0.001]. Significantly higher among those willing to be screened by male HWs than those unwilling [14.4% (60/418) vs 4.7% (3/64), χ2 = 4.57, df = 1, p = 0.033]. Fisher’s exact test showed that CCS uptake among WCBA varied significantly by level of knowledge of CC signs/symptoms, with 66.7% (12/18) and 19.8% (48/243) among those with high-level and low-level knowledge screened, respectively (p < 0.001).
Conclusions
HIV status, ever heard of CC, sources of information, knowledge of CC signs/symptoms, beliefs, recommendations by HWs for CCS, willingness to be screened by male HWs were associated with CCS uptake. These should be prioritized to improve CCS uptake among WCBA.
Design and Analysis of a Syngas Catalytic Combustor for Micro Electrical Mechanical Systems (MEMS)
Authors: Bazooyar Bahamin , Zhu Mingming , Manovic Vasilije , Nabavi Seyed Ali 
Published: December 2022

Abstract
In this work, a catalytic combustor for micro electrical mechanical system using renewable syngas was designed and analysed using Direct Numerical Simulation (DNS) in conjunction with finite rate chemistry. The effect of catalyst (rhodium, palladium, and rhodium), shape and packing of the catalyst and operating conditions (e.g., inlet temperature and velocity, fuel/air ratio, H2 content in the fuel mixture) on combustion efficiency and pressure drop were studied. Findings demonstrate that the catalyst in the shape of intalox saddle resulted in the bed effectiveness factor (An ideal reactor effectiveness factor is 1 which 0.5 is equivalent to 100% combustion efficiency and 0.5 is from 0% pressure drop at the combustor outlet) 0.93, while the packing geometry of the catalyst has negligible impact on the operation of the reactor. Analysis under different operating conditions reveals that the designed reactor can operate effectively with syngas of varying compositions. The combustion mainly takes place on the surface of the catalyst without gas phase reaction. The analyses of Damköhler number demonstrated that the timescale of chemical reactions is at the same order of magnitude for concentration of hydroxyl radicals (OH) over the entire length of the reactor, suggesting a uniform combustion.