bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observational and numerical characterization of a recurrent arc-shaped front propagating along a coronal fan
Authors: Sieyra M. V. , Krishna Prasad S. , Stenborg G. , Khomenko E. , Van Doorsselaere T. , Costa A. , Esquivel A. , Riedl J. M. 
Published: August 2022

Context. Recurrent, arc-shaped intensity disturbances were detected by extreme-ultraviolet channels in an active region. The fronts were observed to propagate along a coronal loop bundle rooted in a small area within a sunspot umbra. Previous works have linked these intensity disturbances to slow magnetoacoustic waves that propagate from the lower atmosphere to the corona along the magnetic field.
Aims. The slow magnetoacoustic waves propagate at the local cusp speed, which is equivalent to the sound speed in a low-β-regime plasma. However, the measured propagation speeds from the intensity images are usually smaller as they are subject to projection effects due to the inclination of the magnetic field with respect to the line of sight. We aim to understand the effect of projection by comparing observed speeds with those from a numerical model.
Methods. Using multi-wavelength data, we determined the periods present in the observations at different heights of the solar atmosphere through Fourier analysis. We calculated the plane-of-sky speeds along one of the loops from the cross-correlation time-lags obtained as a function of distance along the loop. We performed a 2D ideal magnetohydrodynamic simulation of an active region embedded in a stratified atmosphere. We drove slow waves from the photosphere with a three-minute periodicity. Synthetic time–distance maps were generated from the forward-modelled intensities in coronal wavelengths and the projected propagation speeds were calculated.
Results. The intensity disturbances show a dominant period between 2 and 3 min at different heights of the atmosphere. The apparent propagation speeds calculated for coronal channels exhibit an accelerated pattern with values increasing from 40 to 120 km s−1 as the distance along the loop rises. The propagation speeds obtained from the synthetic time–distance maps also exhibit accelerated profiles within a similar range of speeds.
Conclusions. We conclude that the accelerated propagation in our observations is due to the projection effect.
Die Plastische und Ästhetische Chirurgie in Zeiten von Social
Media: Eine Analyse der Reichweite und des Themenfokus der erfolgreichsten
Kanäle auf YouTube
Authors: Alawi Seyed Arash , Bota Olimpiu , Dragu Adrian 
Published: August 2022

Zusammenfassung
Hintergrund Die Nutzung von sozialen Medien wie Facebook, YouTube und
Instagram wird zunehmend ein fester Bestandteil der Kommunikation in der
Plastischen und Ästhetischen Chirurgie. Die potentielle Reichweite
bietet bedeutende Möglichkeiten Informationen zu teilen und Patienten zu
erreichen. Es muss daher zunehmend als modernes Tool für eine neue Form
der Publikation und als Daten- und Wissensbank betrachtet werden. Zielsetzung
dieser Arbeit ist es führende YouTube-Kanäle von deutschen
Plastischen und Ästhetischen Chirurgen auf die Reichweite, Ihren
Kenndaten sowie den Themenfokus zu untersuchen.
Material und Methoden Es erfolgte die Auswertung aller führenden
deutschen YouTube Kanäle von Fachärzten für Plastische
und Ästhetische Chirurgie. Die Analyse beruhte auf Kennzahlen
(Landesranking, Anzahl Uploads, Reichweite mit Gesamtaufrufzahlen,
täglich neue Abonnenten; Assoziation Universitätsklinik,
peripheres Krankenhaus, Privatpraxis) und Inhalt mit konsekutiver
Klassifizierung der Themen der erfolgreichsten Videos.
Ergebnisse Mit dem Stichwort „Plastische Chirurgie“ wurden
376 deutsche Kanäle identifiziert, wobei die erfolgreichsten 8
Kanäle die Einschlusskriterien erfüllten. Im Median erreichten
die erfolgreichsten Kanäle 1.342.017 Aufrufe (IQR
745.455–2.550.682). Die täglichen Aufrufe auf den
Kanälen belaufen sich im Median bei 718 Aufrufen pro Kanal (IQR
272–1.086). Von insgesamt 290 der erfolgreichsten Videos waren
87% der Videos über ästhetische Prozeduren
(n=253). Ein Anteil von 87,5% (7/8) der erfolgreichsten
Kanäle stammen von privatärztlich tätigen Plastischen
und Ästhetischen Chirurgen.
Schlussfolgerung Die Plattform YouTube bietet eine bedeutende Reichweite
für Wissensvermittlung und Marketing. Das Angebot wird aber vornehmlich
von der „Ästhetischen Säule“ genutzt und hier
vor allem aus dem niedergelassenen Bereich. Die Repräsentation und
Darstellung der Plastischen und Ästhetischen Chirurgie mit den festen
Bestandteilen wie der Rekonstruktion, der Handchirurgie und der
Verbrennungschirurgie bietet noch viel Potential zum Ausbau auf dieser
Plattform.
Gua Sha – Anwendung und Wirksamkeit als ausleitendes Therapieverfahren
Authors: Wibisono Gunawan , Sun Weizhong 
Published: August 2022

ZusammenfassungBei der asiatischen Behandlungsform Gua Sha wird ein bestimmter Bereich am Rücken solange mit einem Gegenstand geschabt, bis punktuelle Einblutungen auftreten. Das Prinzip besteht darin, die Temperatur und Lebensenergie (Qi) des Körpers zu erhöhen. Gua Sha gehört noch mehr als das Schröpfen als ausleitendes Therapieverfahren zur Volksmedizin und wird im asiatischen Raum traditionell zur effektiven Prävention von Krankheiten und zur Entgiftung des Körpers angewendet. Der Beitrag beschreibt das Verfahren, deren Anwendung sich im asiatischen Raum großer Beliebtheit erfreut, geht auf die Anwendung sowie Kontraindikationen ein, und verweist auf eine aktuelle deutsche Studie zur Wirksamkeit.
Ulnaverkürzungsosteotomie – Zwei Wochen Ruhigstellung
ausreichend
Authors: Moeller Richard-Tobias , Mentzel Martin , Vergote Daniel , Bauknecht Simon 
Published: August 2022

Zusammenfassung
Hintergrund Die diaphysäre Ulnaverkürzungsosteotomie (UVO)
als operative Behandlung des Ulnaimpaktionssyndromes ist heutzutage
standardisiert mit guten bis sehr guten Ergebnissen. Demgegenüber findet
sich in der aktuellen Literatur ein breites Spektrum an verschiedenen
postoperativen Behandlungsschemata. Die Ergebnisse nach UVO mit modernen,
winkelstabilen Implantaten und postoperativer Immobilisierung für 2
Wochen werden vorgestellt.
Patienten und Methoden In einer retrospektiven Datenbankanalyse konnten in
einem Zeitraum von 13 Jahren 49 Patienten (31 Frauen, 18 Männer,
Durchschnittsalter 37,6 Jahre) mit insgesamt 51 UVO identifiziert und
über 73,5 (15,9–146,1) Wochen nachbeobachtet werden. Alle UVO
wurden schräg gesägt und mit palmaren, winkelstabilen
Implantaten stabilisiert. Postoperativ wurde das Handgelenk für 2 Wochen
in 30° Extension in einer dorsalen Unterarmschiene immobilisiert.
Ergebnisse Alle UVO zeigten belastungsstabile Konsolidierungszeichen nach
durchschnittlich 7,0 (SD 1,9; 4,9–14,1) Wochen. Die Beweglichkeit der
Handgelenke konnte signifikant für die Extension/Flexion von
präoperativ 107,6° (60–155) auf postoperativ
123,7° (80–160) und für die Ulnar-/Radialduktion
von 55,1° (25–90) auf 60,8° (30–90) verbessert
werden (p<0,05). Das Schmerzniveau wurde sowohl in Ruhe von 3,2
(0–8) auf 0,1 (0–2) und unter Belastung von 7,3 (4–10)
auf 1,2 (0–9) signifikant reduziert (p<0,01). Insgesamt wurden 5
Komplikationen (9,8%) festgestellt, Pseudarthrosen fanden sich
nicht.
Schlussfolgerung Durch die Verwendung von winkelstabilen Implantaten zur
Stabilisierung einer UVO kann die Zeitdauer der Ruhigstellung mittels einer
dorsalen Unterarmschiene auf 2 Wochen reduziert werden, ohne die Knochenheilung
zu kompromittieren.
Ökopsychosomatik und Ökoimmunologie: Was Biodiversität mit Gesundheit zu tun hat
Authors: Arvay Clemens G. 
Published: August 2022

SummaryDie Ökopsychosomatik beschreibt die Wirkung vonstofflichen sowie nichtstofflichen Stimulanzien aus Ökosystemenauf die psychische und somatische Gesundheitdes Menschen. Sie erforscht die pathogenen und salutogenenUmwelt- und Natureinflüsse, um die daraus gewonnenenErkenntnisse für die öffentliche Gesundheitsowie für die Therapie von Krankheitszuständen nutzbarzu machen. Im ökopsychosomatischen Paradigma wirdder menschliche Organismus als eingebunden in einenevolutionsbedingten Funktionskreis mit seinen natürlichenLebensräumen betrachtet. Der Mensch ist Teil derBiodiversität. Nicht nur Umweltschadstoffe wirken sichungünstig auf Gesundheit und Genesungsaussichtenaus, sondern auch die Durchbrechung des Funktionskreisesdurch Trennung von den Einflüssen intakter Ökosysteme.Die „Waldmedizin“ ist als evidenzbasiertes Beispielder angewandten Ökopsychosomatik zu betrachten.Der Artikel gibt einen Überblick über dasinterdisziplinäre Feld der Ökopsychosomatik.
New Efficient Synthesis of 6,12-Dihydro-5H-quinazolino[3,2-a] quinazolin-5-ones via Ugi/Staudinger/Aza-Wittig/Addition/Nucleophilic Acyl Substitution Sequence
Authors: Ding Ming-Wu , Yang Mao-Lin , Chen Hao-Ran , Zhao Long 
Published: August 2022

AbstractA new efficient synthesis of 6,12-dihydro-5H-quinazolino[3,2-a]quinazolin-5-ones by sequential Ugi/Staudinger/aza-Wittig/addition/nucleophilic acyl substitution has been developed. α-Amino amides, obtained from Ugi-3CR of 2-azidobenzaldehydes, methyl 2-aminobenzoates, and isocyanides in the presence of catalytic amount of phenylphosphinic acid, reacted with triphenylphosphine and isocyanates to give 6,12-dihydro-5H-quinazolino[3,2-a]quinazolin-5-ones in good yields. This method provides a domino and effective strategy for the preparation of various substituted quinazolino[3,2-a]quinazolin-5-ones under mild reaction condition.
1,4-Naphthoquinone Derivative as Efficient Photolabile Molecule: Concise Synthesis and Photorelease of Various Functional Compounds
Authors: Kawai Tsuyoshi , Morimoto Tsumoru , Liu HaiYing , Suzuki Mikiya , Kakiuchi Kiyomi 
Published: August 2022

AbstractWe report on a series of 1,4-naphthoquinone (NQ)-based photolabile molecules, including various functional compounds to be released under light irradiation. They were efficiently prepared from a common precursor for a photoremovable masking group, by attaching different functional compounds such as alcohols, amines, and acids by a concise synthetic method. Synthesis of the common precursor was optimized for two-step reactions and also for a one-pot reaction involving a 1,4-addition and successive aldol reaction from NQ. The functional compounds, such as alcohols, amines and carboxylic, phosphoric, and sulfonic acids, were masked with the NQ-based precursor and were successfully released by irradiation with UV light (λ = 360 nm) in high yields (>90%).
Generic Health-Related Quality-of-Life Changes after Rhinoplasty: A Prospective Study with Long-Term Results
Authors: Xavier Rui , Azeredo-Lopes Sofia , Menger Dirk-Jan , de Carvalho Henrique Cyrne , Spratley Jorge 
Published: August 2022

Abstract
Objectives Our objective was to investigate changes in specific generic health-related quality-of-life (HRQoL) domains achieved by rhinoplasty, to investigate whether modifications of somatic-, psychologic-, and social-related HRQoL domains are different in patients with functional or aesthetic motivation for rhinoplasty, and to investigate if HRQoL changes are related to a functional or an aesthetic nasal improvement.
Study Design This was a prospective study with 1 year of follow-up.
Methods Fifty-four consecutive Caucasian patients submitted to rhinoplasty were evaluated with 36-item Short Form Health Survey (SF-36) and EuroQuality-of-Life 5 Domain (EQ-5D) questionnaires. To correlate changes in generic HRQoL with functional and aesthetic modifications achieved by rhinoplasty, evaluation of patients also included assessment of Peak Nasal Inspiratory Flow and Nasal Obstruction Symptom Evaluation, Visual Analogue Scale for nasal airway obstruction (NAO), and Rhinoplasty Outcome Evaluation scores.Modifications in each generic HRQoL health-domain were analyzed to investigate the possible relation with motivation for surgery and with functional or aesthetic improvement.
Results There was a significant improvement in EQ-5D (p < 0.001), EQ-5D VAS (p = 0.002) and in the SF-36 domains of general health (p < 0.001), energy (p < 0.001), physical functioning (p < 0.001), physical limitation (p = 0.005), pain (p = 0.003), and well-being (p = 0.018). Improvement was significant in groups of patients with NAO or in whom a septoplasty was performed and was associated with patient-reported functional improvement. There was a significant improvement in health change (p < 0.001), verified in all groups of patients.
Conclusions This prospective study with long-term results demonstrates that rhinoplasty significantly improves most domains of generic HRQoL. This improvement is associated with patient-reported functional improvement. Emotional limitation and social functioning are not significantly changed by rhinoplasty.
Level of Evidence: IV.
A Novel Craniocervical Junction Compression Severity Index-Based Grading System for Multidirectional Quantification of the Biomechanics at Foramen Magnum of Chiari Malformation Type I
Authors: He Yunsen , Liu Ping , Zhang Mengjun , Guo Lili , Zheng Tao , Yao Yuanpeng , Zheng Qiang , Bao Mingbin , Jiang Chuan , Wu Bo , Liu Jinping 
Published: August 2022

Abstract
Objective This study aimed to establish a novel grading system, based on the craniovertebral junction compression severity index (CVJCSI) for multidirectional quantification at the foramen magnum plane for Chiari malformation type I (CMI).
Methods The CVJCSI grading system was established to stratify patients based on the ventral (modified clivoaxial angle < 138°), dorsal (tonsil herniation), and central (brainstem herniation) CVJ (craniovertebral junction) compression, the CVJCSI grading system was established to stratify patients. The optimal surgical method for each grade was recommended by intragroup comparisons regarding the efficacy of the three operations. Finally, according to the CVJCSI grading system, a prospective validation trial was performed and surgically treated for internal validation.
Results Based on the retrospective study (n = 310), the CVJCSI included six grades: I: syrinx alone without compression; II: dorsal compression; III: dorsal and central compression; IV: ventral compression; V: dorsal and ventral compression; and VI: ventral, dorsal, and central compression. Among all available variables, only the CVJCSI and surgical methods significantly affected the CCOS. The CCOS scores, overall and for each CVJCSI grade, increased in the prospective cohort (n = 42) compared with that in the retrospective analysis.
Conclusions The CVJCSI can be used to stratify CMI patients. The higher the CVJCSI grade, the more severe the CVJ compression and the worse posterior fossa deformity. Meanwhile, the CVJCSI was negatively correlated with the CCOS. The lower the CVJCSI grade, the better the response to surgery, and the less-invasive surgical procedures were warranted. Finally, the prospective cohort study validated the proposed CVJCSI-based surgical protocols.
Synthesis of Dehydromuscone by an Alkene Metathesis Macrocyclization Reaction at 0.2 M Concentration
Authors: Leyva-Pérez Antonio , Garnes-Portolés Francisco , Sánchez-Quesada Jorge , Espinós-Ferri Estela 
Published: August 2022

AbstractThe industrial fragrance compound dehydromuscone was synthesized in five linear steps and 19% overall yield. The synthesis features a highly efficient nondiluted ring-closing metathesis macrocyclization reaction as a key step that proceeds at a 0.2 M concentration in the presence of 0.1 mol% Nitro-Grela catalyst. The synthesis employs commercially available linear starting materials and is shorter by at least two steps than the current industrial synthesis route.
Rapid Detection of Apixaban by a ROTEM-Based Approach and Reversibility with Andexanet Alfa or DOAC-Stop
Authors: Taune Viktor , Skeppholm Mika , Ågren Anna , Wikman Agneta , Hillarp Andreas , Wallén Håkan 
Published: August 2022

Abstract
Background A rapid test to detect apixaban treatment would be useful in acute situations such as major bleeding, urgent surgery, or in acute thrombosis.
Objective This article aims to study if the viscoelastic test rotational thromboelastometry (ROTEM) can rapidly detect apixaban in whole blood using modified triggers based on factor Xa (FXa) or Russell viper venom (RVV).
Method ROTEM clotting time (CT) was measured in samples from 40 patients on apixaban treatment, and in vitro in samples spiked with apixaban (20–500 ng/mL). Commercially available trigger Ex-tem was compared with modified triggers based on FXa or RVV. Reversibility of apixaban in the samples was studied; CT was measured with and without addition of DOAC-Stop or andexanet alfa, respectively, and the difference in CT was calculated (CTdiff).
Results Using FXa as trigger, we detected apixaban concentrations at 20 ng/mL and above with 100% sensitivity and 100% specificity in patient samples and in vitro. Corresponding data for Ex-tem were 92% sensitivity and 100% specificity in patients, and 94% sensitivity and 100% specificity in vitro, and for RVV 97% sensitivity and 94% specificity in patients, and 97% sensitivity and 100% specificity in vitro, respectively. CTdiff data were similar. Patient sample data were obtained within 20 minutes from sampling.
Conclusion Apixaban at low therapeutic concentrations was detected within 20 minutes, and with high sensitivity and specificity. A trigger based on FXa outperformed the commercial trigger Ex-tem and a trigger based on RVV. ROTEM with a FXa-based trigger is a promising method to detect apixaban bedside in acute settings.
Misoprostol Administration Before Hysteroscopy Procedures – A Retrospective Analysis
Authors: Inácio Quênya Antunes Silveira , Troncon Júlia Kefalás , Valério Fernando Passador , Herren Helmer , Nogueira Antônio Alberto , Neto Omero Benedicto Poli , Silva Júlio César Rosa e 
Published: August 2022

Abstract
Objective To evaluate the use of misoprostol prior to hysteroscopy procedures regarding technical ease, the presence of side effects, and the occurrence of complications.
Methods This is a retrospective, observational, analytical, case-control study, with the review of medical records of 266 patients followed-up at the Gynecological Videoendoscopy Sector of the Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto of the Universidade de São Paulo (HCFMRP – USP, in the Portuguese acronym) from 2014 to 2019, comparing 133 patients who used the drug before the procedure with 133 patients who did not.
Results The occurrence of postmenopausal uterine bleeding was the main indication for hysteroscopy and revealed a statistical difference between groups (p < 0.001), being present in 93.23% of the patients in the study group and in 69.7% of the patients in the control group. Only 2 patients (1.5%) in the study group reported adverse effects. Although no statistical differences were observed regarding the occurrence of complications during the procedure (p = 0.0662), a higher total number of complications was noted in the group that used misoprostol (n = 7; 5.26%) compared with the group that did not use the drug (n = 1; 0.75%), a fact that is clinically relevant. When evaluating the ease of the technique (measured by the complete performance of all steps of the hysteroscopy procedure), it was verified that although there was no difference between groups (p = 0.0586), the control group had more than twice as many incompletely performed procedures (n = 17) when compared with the group that used misoprostol previously (n = 8), which is also clinically relevant.
Conclusion The use of misoprostol prior to hysteroscopy in our service indicated that the drug can facilitate the performance of the procedure, but not without side effects and presenting higher complication rates.
Long-Term Outcomes of Laminectomy in Lumbar Spinal Stenosis: A Systematic Review and Meta-Analysis
Authors: Sajadi Kiavash , Azarhomayoun Amir , Jazayeri Seyed Behnam , Baigi Vali , Ranjbar Hameghavandi Mohammad Hosein , Rostamkhani Sabra , Atlasi Rasha , Faghih Jooybari Morteza , Ghodsi Zahra , Vaccaro Alexander R. , Khorasanizadeh MirHojjat , Rahimi-Movaghar Vafa 
Published: August 2022

Abstract
Objective Lumbar spinal stenosis (LSS) patients suffer from significant pain and disability. To assess long-term safety and efficacy of laminectomy in LSS patients, a systematic review and meta-analysis study was conducted.
Methods Literature review in MEDLINE, Embase, Scopus, Web of Science, and Cochrane Library databases was performed using a predefined search strategy. Articles were included if they met the following characteristics: human studies, LSS, and at least 5 years of follow-up. Outcome measures included patient satisfaction, pain, disability, claudication, reoperation rates, and complications.
Results Twelve articles met the eligibility criteria for our study. Overall, there was low-quality evidence that patients undergoing laminectomy, with at least 5 years of follow-up, have significantly more satisfaction, and less pain and disability, compared with the preoperative baseline. Assessment of neurogenic intermittent claudication showed significant improvement in walking abilities. We also reviewed the postoperative complication and adverse events in the included studies. After meta-analysis was performed, the reoperation rate was found to be 14% (95% confidence interval: 13–16%).
Conclusion Our study provides low-quality evidence suggesting that patients undergoing laminectomy for LSS have less disability and pain and can be more physically active postoperatively.
The expected impact of cultivated and plant-based meats on jobs: the views of experts from Brazil, the United States and Europe
Authors: Morais-da-Silva Rodrigo Luiz , Villar Eduardo Guedes , Reis Germano Glufke , Sanctorum Hermes , Molento Carla Forte Maiolino 
Published: August 2022

AbstractCultivated and plant-based meats are substitutes for conventional animal meat products. As radical innovations, they may trigger profound social and economic changes. Despite the many benefits of alternative meats, such as environmental sustainability, animal welfare, human health and food safety, some unintended consequences remain unexplored in the literature. In this paper, we studied the potential impact of the meat production system transition on jobs. Using a survey, we compared opinions regarding the impact on jobs in Brazil, the United States and Europe, according to alternative protein experts. Our results showed the potential of plant-based and cultivated meat production to create new and higher-skilled jobs. The data analysis also suggested that the impact of novel food production systems on jobs in conventional meat production may be different for each stage of the value chain. In particular, the results showed a pressure point on animal farmers, who may be most affected in a fast transition scenario. Considering the studied geographical contexts, Brazilian professionals were more optimistic about the potential of plant-based and cultivated meat production to create new jobs. Our findings may provide new insights for the development of policies, measures and strategies that promote job creation, skills and income in view of the ongoing transition.