bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic gastric dissociation using two-port approach in minimally invasive esophagectomy
Authors: Pan Huaguang , Zhang Renquan , Li Ao , Fang Hanlin , Zheng Hao , Jiang Menglong , Ge Wei , Zhou Fan , Liu Xiancheng , Yin Chuntong 
Published: September 2022

Abstract
Background
A new approach of laparoscopic gastric dissociation in minimally invasive esophagectomy (MIE) was attempted. This study aimed to evaluate the safety and efficacy of two-port laparoscopy in McKeown procedure.
Methods
From August 2019 to August 2021, 206 patients with esophageal cancer underwent laparoscopic modified two-port or traditional five-port McKeown procedure in our institution. Surgical outcomes of the methods were compared.
Results
Of the patients, 106 (51.46%) underwent modified two-port procedure, while 100 (48.54%) underwent traditional five-port procedure. Propensity score matching produced 182 patients for comparison. The laparoscopic operative time was 48.40 ± 13.33 and 45.75 ± 10.65 min, respectively (p = 0.140). There was no significant difference in the median number of dissected celiac lymph nodes in both groups (7.69 ± 3.37 vs. 8.56 ± 6.54, p = 0.262). The number of positive celiac lymph nodes was 0.36 ± 1.01 and 0.64 ± 1.32, respectively (p = 0.116). Blood loss during laparoscopic surgery in the modified two-port group was similar to that in the traditional five-port group (16.87 ± 18.93 mL vs. 15.88 ± 17.62 mL, p = 0.716). The postoperative length of hospital stay was 10.21 ± 4.23 days and 10.22 ± 4.24 days, respectively (p = 0.986). Complication rates in both groups were not significantly different (13.2% vs. 18.7%, p = 0.563). There was no significant difference in postoperative abdominal pain VAS scores between the two groups (p > 0.05).
Conclusions
The modified McKeown procedure with two-port laparoscopy is a viable option for patients with esophageal cancer. Larger studies with longer follow-up duration are warranted.
TET2 and LILRB3 mutations are frequent in EBV-positive diffuse large B-cell lymphoma especially in elderly patients
Authors: Cho Junhun , Kim Eojin , Yoon Sang Eun , Kim Seok Jin ,   Won Seog 2 Kim
Published: September 2022

Abstract

Diffuse large B-cell lymphoma harboring Epstein–Barr virus (EBV) primarily occurs in patients with underlying immunodeficiency or elderly patients with immune senescence but is also reported in young, immunocompetent patients. We investigated the pathological differences in EBV-positive diffuse large B-cell lymphoma in these three groups of patients. A total of 57 patients with EBV-positive diffuse large B-cell lymphoma were included in the study; of these, 16 were immunodeficiency-associated patients, 10 were young (age <50 years), and 31 were elderly patients (age ≥50 years). Immunostaining for CD8, CD68, PD-L1, and EBNA2 and panel-based next-generation sequencing were performed. The histologic type was monomorphic in 46 patients and polymorphic in seven patients. Immunohistochemistry revealed EBNA2 positivity in 21 of the 49 patients. The degree of CD8 and CD68-positive immune cell infiltration and PD-L1 expression did not significantly differ in each group. The clinical characteristics of the three groups were generally similar; however, extranodal site involvement was more common in young patients (P=0.021). In mutational analysis, the genes with the highest mutation frequency were PCLO (n=14), TET2 (n=10), and LILRB1 (n=10). For TET2 gene, all 10 mutations were found in elderly patients (P=0.007). For LILRB1, 8 out of 10 mutations were found in elderly patients (P=0.184). In comparison with a validation cohort, both TET2 and LILRB1 showed a higher mutation frequency in EBV-positive than EBV-negative cases. EBV-positive diffuse large B-cell lymphoma occurring in three different age and immune status groups showed similar clinical and pathological characteristics. Notably, high frequency of TET2 and LILRB1 mutations was characteristic to this disease in elderly patients. Further studies are needed to determine the role of TET2 and LILRB1 mutations in the development of EBV-positive diffuse large B-cell lymphoma along with immune senescence.
Hydrophobic nanocoating impacts on the PV panels' current-voltage and power-voltage curves.
Authors: Elsaadawi Youssef , Tayel Samir Ahmed , El-Maaty Ashour Eid Abu , Mostafa Eman Mohamed 
Published: September 2022

Abstract
Numerous factors, such as dust accumulation and light reflection off PV panel surfaces, adversely affect the performance and efficiency of PV solar panels. On PV panels, dust accumulation increases with time. Irradiation losses caused by dust deposition have a negative impact on PV solar panels. Regular cleaning is necessary for PV panel maintenance, but when carried out manually, it is labor-intensive. The hand-cleaning techniques use a lot of water and energy. The automated cleaning methods initially cost a lot of money and need an electrical source to function. As a result, self-cleaning techniques like hydrophobic coatings are popular since they don't require power and don't leave scratches on panels during cleaning. Since the current-voltage curve, the power-voltage curve, and the fill factor are the most indicative factors of the efficiency and performance of photovoltaic panels, the impact of hydrophobic nanocoating and dust on these factors was investigated in this study. The study showed that the nano coating was hydrophobic and had a self-cleaning effect. After 40 days of exposure to outdoor conditions, the dust density on RP and PNP before water spraying (self-cleaning) was 10 and 4.30 g/m 2 , while the dust density after water spraying(self-cleaning) was 4.80 and 1.12 g/m 2 respectively. The I-V curve for a clean reference panel (RP) and a prepared-nanocoated panel (PNP) showed that the short circuit current Isc was 5.69, 5.7, and 5.82 A, and the open circuit voltage Voc was 20.3 and 20.7 V respectively. The fill factor for PNP (0.7) was higher than RP (0.68). For dusty panels, the short circuit current Isc was 4.80 and 5.65 A, and the open circuit voltage Voc was 20.0 and 20.2 V, respectively. The fill factor for PNP (0.69) was higher than RP's (0.63). The nano coating has a highly positive impact on the I-V curve, P-V curve, and fill factor. That’s because of its anti-reflective and self-cleaning effect.
Effects of Hydrogen-Rich Saline in Neuroinflammation and Mitochondrial Dysfunction in Rat Model of Sepsis-associated Encephalopathy
Authors: DUMBUYA John Sieh , LI Siqi , LIANG Lili , CHEN Yachen , DU Jiang , ZENG Qiyi 
Published: September 2022

Abstract
Background
Sepsis-associated encephalopathy (SAE) is one of the most common types of sepsis-related organ dysfunction without overt central nervous system (CNS) infection. It is associated with higher mortality, low quality of life, and long-term neurological sequelae in suspected patients. At present there is no specific treatment for SAE rather than supportive therapy and judicious use of antibiotics, which are sometimes associated with adverse effects. Molecular hydrogen (H2) has been reported to play crucial role in regulating inflammatory responses, neuronal injury, apoptosis and mitochondrial dysfunction in adult models of SAE. Here we report the protective effect of hydrogen-rich saline in juvenile SAE rat model and its possible underling mechanism(s).
Materials and methods
Rats were challenged with lipopolysaccharide (LPS) at a dose of 8ml/kg injected intraperitoneally to induce sepsis and hydrogen-rich saline (HRS) administered 1h following LPS induction at a dose of 5ml/kg. Rats were divided into: sham, LPS and LPS + HRS. At 48h, rats were sacrificed and Nissl staining for neuronal injury, TUNEL assay for apoptotic cells detection, immunohistochemistry, and ELISA protocol for inflammatory cytokines determination, mitochondrial dysfunction parameters, electron microscopy and western blot analysis were studied to examine the effect of HRS in LPS-induced septic rats.
Results
Rats treated with HRS improved neuronal injury, improvement in rats’ survival rate. ELISA analysis showed decreased TNF-α and IL-1β and increased IL-10 expression levels in the HRS-treated group. Apoptotic cells were decreased after HRS administration in septic rats. The numbers of GFAP and IBA-1positive cells were attenuated in the HRS-treated group when compared to the LPS group. Subsequently, GFAP and IBA-1 immunoreactivity were decreased after HRS treatment. Mitochondrial membrane potential detected by JC-1 dye and ATP content were decreased in septic rats, which were improved after HRS treatment, while release of ROS was increased in the LPS group reverted by HRS treatment, ameliorating mitochondrial dysfunction. Further analysis by transmission electron microscopy showed decreased number of mitochondria and synapses, and disrupted mitochondrial membrane ultrastructure in the LPS group, while HRS administration increased mitochondria and synapses number.
Conclusion
These data demonstrated that HRS can improve survival rate, attenuate neuroinflammation, astrocyte and microglial activation, neuronal injury and mitochondrial dysfunction in juvenile SAE rat model, making it a potential therapeutic candidate in treating paediatric SAE.
Ten Years Follow-Up of Aphakia Treatment by a Foldable Posterior Chamber Intraocular Lens Implantation into the Anterior Chamber
Authors: Boz Ali Altan Ertan , Atum Mahmut , Çelik Erkan , Alagöz Gürsoy 
Published: September 2022

Abstract
Purpose
To report the 10 years’ results of aphakia treatment by a foldable posterior chamber intraocular lens (PCIOLs) implantation into the anterior chamber.
Methods
Retrospective observational case series. Patients who underwent implantation of foldable PCIOLs in the AC with the haptics passing through two iridectomies to the posterior chamber were studied. Preoperative and postoperative refractive status, postoperative corneal astigmatism, lenticular astigmatism, and complications were recorded. Anterior chamber depth (ACD) was detected by ultrasonic biomicroscopy (UBM).
Results
Fifty-one eyes of 51 patients were included in the study. Of these eyes, 21 eyes were examined at 10 years postoperatively. The mean preoperative corrected distance visual acuity (CDVA) was 1.06 ± 0.68 logMAR and postoperative was 0.49 ± 0.44 at 1 year (p < 0.01); 0.49 ± 0.44 (p < 0.01) at 2 years; and 0.45 ± 0.39 (p < 0.01) at 10 years. The mean lenticular astigmatism was 0.96 ± 0.78 D. Glaucoma in 11 eyes, retinal detachment in 3 eyes, cystoid macular edema in 6 eyes, corneal decompensation in 11 eyes, and haptic dislocation in 7 eyes were observed. The mean distance between the IOL and the endothelium was 3,03 ± 0.29 mm.
Conclusions
Advantages of our technique are lack of a need for special design lenses and surgical equipment, small learning curve, and faster surgical time. This technique is a practical alternative that leads to favorable visual outcomes and is comparable to the complications of other techniques in the eyes with the absence of capsular support.
Design and Evaluation of Memristor-Based Piccolo-80 Lightweight Encryption Algorithm for Future IoT Applications
Authors: Masoumi Massoud 
Published: September 2022

Abstract
Piccolo is an ultra-lightweight encryption algorithm optimized for very resource-constrained platforms. However, lightweight algorithms are vulnerable to side-channel attacks, specifically Differential Power Analysis (DPA). In this study, we first demonstrate the vulnerability of this algorithm against DPA. Then, a new masking scheme to protect the algorithm against DPA is proposed. In addition, the same implementation in a hybrid CMOS-Nano system is presented and the results are compared in terms of attack tolerance, area, and energy consumption. Power analysis mounted on unmasked Piccolo was successful while the attack on the masked version of both CMOS and CMOS-Nano implementations of the algorithm led to unsuccessful results and no key was recovered. More importantly, while maintaining reliable performance, the hybrid CMOS-Nano circuit was more efficient than the pure CMOS circuit in terms of energy consumption and area. This is a very important issue for future IoT devices and applications where energy consumption and security are the primary concerns.
An integrated indexical approach in assessing water quality for drinking purposes in the Nkalagu area, southeastern, Nigeria
Authors: Onwe Ikechukwu Moses , Chinanu Unigwe O. , Amah Joseph I. , Chima Chizoba J. 
Published: September 2022

Abstract
In this study, water supplies for the two distinct climatic seasons; wet and dry seasons were evaluated. This was carried out to determine the degree of contamination and whether the water supplies were safe for human consumption. In light of this, four water quality indices; the vector modulus of pollution index (PIvector), entropy-weighted water quality index (EWQI), integrated water quality index (IWQI), and modified water quality index (MWQI) were integrated. Based on the results, the pH of the analyzed water samples varied from 6.02 to 7.92 with a mean value of 7.2 during the wet season and from 5.25 to 8.25 with a mean value of 6.82 during the dry season. A generic quality assessment study revealed that Pb, As, during the wet season and Pb, As, and Mn during the dry season has the greatest effects on the region's water supplies. According to the indices, PIvector classified approximately 71.43% of the water during the wet season as unpolluted and 28.57% as polluted, and 37.14% of the water during the dry season as unpolluted and 62.86% as polluted. Similarly, the EWQI classified 65.71% as safe water and 34.28% as unfit for human consumption during the wet season, whereas, 34.28% and 65.72% as safe and unfit respectively for the dry season. According to IWQI, during the wet season, 25.7% of the water is considered acceptable for drinking, while 74.3% is unsafe, and during the dry season, 14.85% is acceptable and 85.15% is unsafe. The MWQI results indicated that the water samples for the wet season were classed as "fair" water suggesting they are occasionally threatened while, for the dry season as “marginal” water indicating they are frequently threatened. Summarily, the results show that the water resources are safer and less contaminated in the wet season than in the dry season, which is attributed to the impact of rainfall, which reduces the mobility of contaminants, as well as the influence of vegetation cover.
Dye degradation by early colonizing marine bacteria from the Arabian Sea, India
Authors: Kumar Madhav , Kumari Alka , Vaghani Bansari P. , Chaudhary Doongar 
Published: September 2022

Abstract
Malachite green (MG) dye belongs to the triphenylmethane group, a common environmental pollutant that threatens non-target organisms. The potential of the early colonizing marine bacterium Pseudomonas sp. ESPS40 isolated from the Arabian Sea, India, to decolorize malachite green (MG) was assessed in the present study. The bacterium ESPS40 exhibited a higher ability for MG degradation (86-88%) at varying NaCl concentrations (1-3%). The most increased MG degradation (~88%) was observed at 1% NaCl. The strain ESPS40 showed degradation up to 800 mg MG L-1 concentration. Further, enzyme activities such as tyrosinase (63.48-526.52 U L-1) and laccase (3.62-28.20 U L-1) were also analyzed with varying concentrations (100 mg L-1-1000 mg L-1) of MG during the degradation process. The dye degradation was confirmed by Fourier transform infrared spectroscopy (FTIR) and high-performance liquid chromatography (HPLC). The outcome of the present study demonstrated the potential of Pseudomonas sp. ESPS40 for efficient degradation of MG at higher concentrations. Thus, the bacterial strain (Pseudomonas sp. ESPS40) can be utilized as a potential candidate for the biodegradation of MG in wastewater treatment.
Micro- and Macrocirculatory effects of norepinephrine on anaesthesia- induced hypotension
Authors: Kindermans Manuel , Joachim Jona , Manquat Elsa , Levé Charlotte , Hong Alex , Mateo Joachim , Mebazaa Alexandre , Gayat Etienne , Backer Daniel , Vallée Fabrice 
Published: September 2022

Abstract
Purpose: Intraoperative arterial hypotension (IOH) leads to increased postoperative morbidity and mortality. Norepinephrine is often use to treat IOH. However, the question regarding the mode of administration in either a bolus or continuous infusion (CI) remains unanswered. The aim of the present study was to describe and compare the effects on macrocirculation and microcirculation of a bolus and a CI of norepinephrine to treat IOH.Methods: We conducted a prospective observational study with adult patients who underwent neurosurgery. Patients with invasive arterial blood pressure and cardiac output (CO) monitoring were screened for inclusion. All patients underwent microcirculation monitoring by video capillaroscopy, laser doppler, near-infrared spectroscopy technology, and tissue CO2. In case of IOH, the patient could receive either a bolus of 10 µg or a CI of 200 µg/h of norepinephrine.Results: Thirty-six patients were included, with 41 boluses and 33 CI.Bolus and CI induced an increase in mean arterial pressure of +30[20-45] and +23[12-34] %, respectively (P=0,07). For macrocirculatory parameters, CI was associated with a smaller decrease in CO and stroke volume (p<0.05).For microcirculatory parameters, a more favourable response was observed when CI was used. Perfusion index (-12 vs. +12%, p=0,008), microvascular flow index (-0,1 vs. + 0,3, p=0,03), total vessel density (-0,2 vs. +2,3 mm2/mm2, p=0,002), and perfusion vessel density (-0,36 vs. +1,44 mm2/mm2, p=0,01) showed opposite variations with bolus and CI, respectively.Conclusions: These results on macro- and microcirculation could reveal the need for the preferential use of a continuous infusion of norepinephrine rather than a bolus to treat anaesthesia-induced hypotension.Trial registration : (NOR-PHARM: 1-17-42 Clinical Trials: NCT03454204).
A study of the RLC, RC, and RL electric circuits associated with incomplete I-functions
Authors: Jangid Kamlesh , Nishant M , Samei Mohammad Esmael , Bhatter Sanjay , Purohit Sunil Dutt 
Published: September 2022

Abstract
The goal of this article is to figure out the electric circuit responses under an impressed voltage E0 f(w) associated with incomplete I-functions and incomplete Ī-functions. The analytical solutions for the RLC, RC and RL circuit are derived using the Laplace transform approach.(2010) Mathematics Subject Classifications: 33B20; 33E20; 26A33.
Determining Sex in Golden Eagle (Aquila Chrysaetos) Chicks
Authors: Peniche Gabriela , Shaw Darren J , Dures Simon G , Ciavaglia Sherryn , Thompson Des BA , Anderson Neil E , Meredith AL 
Published: September 2022

Abstract
Incorporating sex ratios of chicks into population viability studies increases knowledge of overall health of endangered populations. Currently a reliable non-invasive method to identify the sex of golden eagle chicks is not available, despite this, claims are commonly made based on morphology. Ten biometric measurements from 43 Scottish golden eagles aged 2-7½ weeks were assessed to see if sex could actually be determined using this non-invasive methodology. Sex was confirmed via molecular analysis of blood samples. Discrete and principal component analyses of the different biometrics could not correctly determine individual chick sex. Therefore, despite being more invasive, molecular sexing remains the recommended tool of choice for accurate sex identification of Scottish golden eagle chicks younger than 7½ weeks of age. This has important implications for golden eagle field studies where empirical morphological measurements are frequently and typically taken, but we have shown are not reliable in determining the sex of such young chicks.
Relative cerebral blood volume as response predictor in the treatment of recurrent glioblastoma with anti-angiogenic therapy
Authors: Yerpes Michele Breda , Rodríguez-Hernández Luis A , Gómez-Figueroa Enrique , Mondragón-Soto Michel G , Arellano-Gomez Gerardo , Hernandez-Hernandez Alan , Martinez Pablo , Perez-González Victoria , Reyes-Moreno Ignacio , Alvaro-Heredia Juan A , Gutierrez-Acevez Guillermo , Peiro-Osuna Pamela , Cacho Bernardo , Villanueva-Castro Eliezer , Deitos Marcos V Sangrador , Alonso-Vanegas Mario , Guerrero-Juarez Vicente , Lopez-Martinez Manuel , Castro-Martínez Elvira , Alberto González-Aguilar 
Published: September 2022

Abstract
Introduction
Glioblastoma is one of the most common brain tumors in adult populations, usually carrying a poor prognosis. While several studies have researched the impact of anti-angiogenic therapies, especially anti VEFG treatments in glioblastoma, few have attempted to assess its progress using imaging studies.
Purpose
We attempted to analyze whether cerebral blood volume (rCBV) from dynamic susceptibility-weighted contrast-enhanced MRI (DSC-MRI) could predict a response in patients with glioblastoma undergoing Bevacizumab (BVZ) treatment.
Methods
We performed a retrospective study evaluating patients with recurrent glioblastoma receiving anti-angiogenic therapy with BVZ between 2012 and 2017 in our institution. Patients were scheduled for routine MRI at baseline and first month follow up visits. Studies were processed for DSC-MRI, cT1 and FLAIR images, from which relative cerebral blood volume measurements were obtained. We assessed patient response using the Response Assessment in Neuro-Oncology (RANO) working group criteria and overall survival.
Results
40 patients were included in the study and were classified as Bevacizumab responders and non-responders. Average rCBV before treatment was 4.5 for both groups and average rCBV was 2.5 for responders and 5.4 for non-responders. ROC curve set a cutoff point of 3.7 for rCBV predictive of response to BVZ. Cox Multivariate analysis only showed rCBV as a predictive factor of OS.
Conclusion
A statistically significant difference was found in rCBV between patients who responded and those who did not respond to BVZ treatment. rCBV may be a low cost and effective marker to assess response to Bevacizumab treatment in GBM.
Generalized partially bent functions, generalized perfect arrays and cocyclic Butson matrices
Authors: Armario José Andrés , Egan Ronan , Flannery Dane 
Published: September 2022

Abstract
In a recent survey, Schmidt compiled equivalences between generalized bent functions, group invariant Butson Hadamard matrices, and abelian splitting relative difference sets.We establish a broader network of equivalencesby considering Butson matrices that are cocyclic rather than strictly group invariant.This result has several applications; for example,to the construction of Boolean functions whose expansions are generalized partially bent functions, including cases where no bent function can exist.Mathematics Subject Classification (2010) 15B34 · 05B20 · 94D05
Novel pruning and truncating of the mixture of vine copula clustering models
Authors: Alanazi Fadhah Amer 
Published: September 2022

Abstract
The mixture of the vine copula densities allows selecting the vine structure, the most appropriate type of parametric marginal distributions, and the pair-copulas individually for each cluster. Therefore, complex hidden dependence structures can be fully uncovered and captured by the mixture of vine copula models without restriction to the parametric shape of margins or dependency patterns. However, this flexibility comes with the cost of dramatic increases in the number of model parameters as the dimension increases. Pruning and truncating each cluster of the mixture model will dramatically reduce the number of model parameters. This paper, therefore, introduced the first pruning and truncating techniques for the model-based clustering algorithm using the vine copula model, providing a significant contribution to the state-of-the-art. We apply the proposed methods to a number of well-known data sets with different dimensions. The results show that the performance of the individual pruning and truncation for each model cluster is superior to an existing vine copula clustering model.