bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of buprenorphine/naloxone to treat borderline personality disorder: a case report
Authors: Hansen Brenna , Inch Katelyn M. , Kaschor Brenna A. 
Published: March 2022

Abstract
Background
Using traditional pharmacotherapy to treat Borderline Personality Disorder (BPD) such as mood stabilizers and second-generation antipsychotics has a lack of supporting evidence. Buprenorphine/Naloxone (BUP/N), a combination medication consisting of a partial opioid agonist, and a full opioid antagonist, is an effective treatment for opioid use disorder. It has also been found effective for treatment-resistant mood disorders. Previous studies suggest a relationship between BPD and endogenous opioids, therefore our case report investigates the effect of BUP/N on a patient diagnosed with BPD.

Case presentation
A 26-year-old female diagnosed with BPD, having recurrent visits to the emergency department (ED) for self-harm/suicidality was treated with BUP/N. Usage of crisis services, ED visits, and hospital admissions were tracked from 15 months prior to BUP/N to 15 months after using BUP/N. Since starting BUP/N, the length and frequency of mental health-related hospital admissions decreased drastically, as did the number of times that she reached out to community crisis services. Since the dosing adjustment to 6 mg in Oct 2020, there have been no calls to the community crisis lines.

Conclusions
We suggest pharmacological treatment targeting BPD as a disorder of distress tolerance and self-soothing mediated by the opioid system is an effective individual healing attempt. An important note is that this patient did not use opioids prior to BUP/N and had never been diagnosed with an opioid use disorder. However, she exhausted multiple other pharmacologic therapies and was open to trying whatever was available to improve her quality of life.
Ground motions induced by pore pressure changes at the Szentes geothermal area, SE Hungary
Authors: Békési Eszter , Fokker Peter A. , Candela Thibault , Szanyi János , van Wees Jan-Diederik 
Published: March 2022

AbstractExcessive thermal water volumes have been extracted from porous sedimentary rocks in the Hungarian part of the Pannonian Basin. Thermal water production in Hungary increased significantly from the early 1970s. Regional-scale exploitation of geothermal reservoirs without re-injection resulted in basin-scale pressure drop in the Upper Pannonian (Upper Miocene) sediments, leading to compaction. This compaction resulted in ground subsidence primarily through poro-elastic coupling.We investigated surface deformation at the Szentes geothermal filed, SE Hungary, where the largest pressure decline occurred. Subsequently, hydraulic head recovery in the western part of the geothermal reservoir was initiated in the mid-1990s. We obtained data from the European Space Agency’s Envisat satellites to estimate the ground motions for the period of November 2002–December 2006. We applied inverse geomechanical modeling to estimate reservoir properties and processes. We constrained the model parameters using the Ensemble Smoother with Multiple Data Assimilation, which allowed us to incorporate large amounts of surface movement observations in a computationally efficient way. Ground movements together with the modeling results show that uplift of the Szentes geothermal field occurred during the observation period. Since no injection wells were operated at Szentes before 2018, and production temperatures remained relatively constant through the entire production period, we explain ground uplift with pore pressure increase due to natural recharge. The estimated decompaction coefficients of the reservoir system characterizing the elastic behavior of the Szentes geothermal reservoir varies between ~ 0.2 × 10–9 and 2 × 10–9 Pa−1. Compaction coefficients of the reservoir system corresponding to the earlier depressurization period, from ~ 1970 to the mid-1990s, may be significantly larger due to the potential inelastic behavior and permanent compaction of clay-rich aquitards. The improved parametrization enables better forecasting of the reservoir behavior and facilitates the assessment of future subsidence scenarios that are helpful for the establishment of a sustainable production scheme.
Minimizing the risk of graft failure after anterior cruciate ligament reconstruction in athletes. A narrative review of the current evidence
Authors: Costa Giuseppe Gianluca , Perelli Simone , Grassi Alberto , Russo Arcangelo , Zaffagnini Stefano , Monllau Juan Carlos 
Published: March 2022

AbstractAnterior cruciate ligament (ACL) tear is one of the most common sport-related injuries and the request for ACL reconstructions is increasing nowadays. Unfortunately, ACL graft failures are reported in up to 34.2% in athletes, representing a traumatic and career-threatening event. It can be convenient to understand the various risk factors for ACL failure, in order to properly inform the patients about the expected outcomes and to minimize the chance of poor results. In literature, a multitude of studies have been performed on the failure risks after ACL reconstruction, but the huge amount of data may generate much confusion.The aim of this review is to resume the data collected from literature on the risk of graft failure after ACL reconstruction in athletes, focusing on the following three key points: individuate the predisposing factors to ACL reconstruction failure, analyze surgical aspects which may have significant impact on outcomes, highlight the current criteria regarding safe return to sport after ACL reconstruction.
Learning with a digital escape room game: before or after instruction?
Authors: Buchner Josef , Rüter Martina , Kerres Michael 
Published: March 2022

AbstractIn this study, we investigated whether playing an escape room game after explicit instruction (instruction-first group, N = 20) is more effective to learn about copyright and media law than playing the game before explicit instruction (problem-solving-first group, N = 21). This is an important question as escape room games are complex, problem-based learning environments that can overwhelm learners and thus hinder the acquisition of knowledge and skills. According to cognitive load theory, preparing learners with explicit instruction before problem-solving activities can overcome this problem leading to better learning. However, in the productive failure paradigm problem-solving before explicit instruction is seen as more effective, especially when it comes to the application of newly acquired knowledge to solve novel problems. Based on these two theories, we conducted an experiment and found that playing the developed digital escape room game after explicit instruction was more effective for knowledge retention and domain-specific self-efficacy with at the same time lower cognitive load. However, we found no differences regarding the application of knowledge as both groups scored equally high on transfer tasks. The result is discussed considering previous productive failure studies mostly conducted in the science and engineering domain. In sum, the instruction first approach proved to be effective for both knowledge acquisition and knowledge application, leading to higher domain-specific self-efficacy and lower cognitive load. Therefore, we conclude that the implementation of escape room games after instruction is an effective instructional approach and better suited to promote learning than playing escape room games before instruction.
Treatment of massive hemoptysis after thoracic aortic aneurysm repair
Authors: Morimura Fumio , Hamamoto Kohei , Edo Hiromi , Ishida Osamu , Tsustsumi Koji , Tamada Soichiro , Kuwamura Hiroshi , Enjoji Yasuhiro , Suyama Yohsuke , Sugiura Hiroaki , Watanabe Sadahiro , Ozaki Ippei , Shinmoto Hiroshi 
Published: March 2022

Abstract
Background
Massive hemoptysis after thoracic aortic aneurysm (TAA) repair is a rare but potentially lethal condition. Endovascular management is a challenging treatment option due to the complexity of culprit vessel access.

Case presentation
An 81-year-old woman was referred to our hospital with massive hemoptysis. She had a history of graft replacement and thoracic endovascular aortic repair (TEVAR) for dissecting TAA. Computed tomography (CT) showed massive atelectasis with hematoma in the left lower lung lobe adjacent to the descending aortic aneurysm treated with TEVAR. Contrast-enhanced CT revealed a pseudoaneurysm and proliferation of abnormal vessels at the peripheral side of the left pulmonary ligament artery (PLA) in the atelectasis. The PLA continued to the right subscapular artery via a complex collateral pathway. Diagnostic angiography of the right subcapsular artery revealed a pseudoaneurysm and abnormal vessels at the peripheral side of the left PLA with a systemic-pulmonary artery shunt. Transcatheter arterial embolization (TAE) for the left PLA via the collateral pathway with N-butyl cyanoacrylate achieved complete embolization. The patient’s hemoptysis was controlled and she was discharged.

Conclusions
Here we presented a case of massive hemoptysis due to PLA disruption that occurred after TAA repair. TAE via a complex collateral pathway is a feasible and effective treatment for hemoptysis, even in patients who have undergone surgical or endovascular TAA repair.
Association between primary osteoarthritis and ADAMTS14 single nucleotide polymorphism in Egyptian population: a case-control study
Authors: Mostafa Noha Abdelhady Abdelsadek , Ibrahim Ibrahim Khalil , Mikhael Neveen Lewis , Saba Emmanuel Kamal Aziz 
Published: March 2022

Abstract
Background
Primary osteoarthritis is considered one of the most common and the most studied musculoskeletal disorder. Nevertheless, the risk factors remain unclear. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 14 (ADAMTS14) gene is involved in the cleavage of amino-terminal propeptides from type II procollagen, a necessary step in the formation of collagen fibers. The abnormal metabolism of collagen fibers type II leads to a decreased mechanical strength of joint cartilage which is one of the most important contributing factors to joint osteoarthritis. We aimed at investigating the association between primary osteoarthritis and ADAMTS14 gene rs4747096 single nucleotide polymorphism in a sample of Egyptian patients and analyzing the relationship between this genetic polymorphism with the severity of osteoarthritis. Sixty-five Egyptian patients who fulfilled the American College of Rheumatology criteria for primary knee osteoarthritis were compared with thirty-one apparently healthy subjects. Genotyping was performed by TaqMan single nucleotide polymorphism genotyping assay.

Results
There was a statistically significantly higher frequency of AA genotype among osteoarthritis patients compared to the control group (P = 0.004). The number of affected hand joints was significantly higher among patients with ADAMTS14 AA genotype in comparison to patients with ADAMTS14 AG genotype (P = 0.002). In addition, AA genotype was associated with statistically significantly higher Kellgren-Lawrence radiological grades in the knee and hand joints (proximal interphalangeal and thumb interphalangeal joints) (P = 0.037, 0.003, and 0.030 respectively).

Conclusion
The study showed an association between the AA genotype of ADAMTS14 gene rs4747096 single nucleotide polymorphism with knee and hand osteoarthritis and osteoarthritis severity in these joints. The AA genotype of ADAMTS14 gene rs4747096 single nucleotide polymorphism could be implicated in the increased incidence of primary osteoarthritis development and elevated disease severity among the Egyptian population.
Integrating neural networks in least-squares inversion of airborne time-domain electromagnetic data
Authors: Asif Muhammad Rizwan , Foged Nikolaj , Maurya Pradip Kumar , Grombacher Denys James , Christiansen Anders Vest , Auken Esben , Larsen Jakob Juul 
Published: March 2022

Airborne time-domain electromagnetic surveys produce extremely large data sets with thousands of line kilometers of data and millions of possible models to explain the data. Inversion of such data sets to obtain the resistivity structures of the subsurface is computationally intensive and involves calculation of a significant number of forward and derivative responses for solving the least-squares inverse problem. The flight altitude of the airborne system needs to be included in the modeling, which adds further complexity. We propose to integrate neural networks in a damped iterative least-squares inversion framework to expedite the inversion process. We train two separate neural networks to predict the forward responses and partial derivatives independently for a broad range of resistivity structures and flight altitudes. Data inversion is not only used for producing the final subsurface models but also used during data processing, or to produce intermediate results during a survey. With these purposes in mind, we provide three inversion schemes with a tunable balance between computational time and modeling accuracy: (1) numerical forward responses used initially in combination with neural network derivatives, and the derivatives switched to a numerical solution in final iterations, (2) numerical forward responses in combination with neural network derivatives used throughout the inversion, and (3) only neural network forward responses and derivatives used in inversion. Experiments on field data find that we improve inversion speed without any loss in modeling accuracy with our first approach, whereas the second scheme gives a significant speedup at the cost of minor and often acceptable deviations in the inversion results from the conventional nonlinear inversion. The last approach is the fastest and captures the overall resistivity structures quite well. Therefore, depending on the modeling accuracy, inversion speedup factors of up to 50 are realized by using the proposed schemes.
Establishing a business case for setting up early detection services for preventing psychosis
Authors: Napoletano Flavia , Andlauer Olivier , Murguia-Asensio Silvia , Eranti Savithasri V. , Akyuz Elvan , Estradé Andrés , Buhagiar Jonathan , David Christine , Fusar-Poli Paolo , Gupta Susham 
Published: March 2022

SummaryUnder standard care, psychotic disorders can have limited response to treatments, high rates of chronicity and disability, negative impacts on families, and wider social and economic costs. In an effort to improve early detection and care of individuals developing a psychotic illness, early intervention in psychosis services and early detection services have been set up in various countries since the 1980s. In April 2016, NHS England implemented a new ‘access and waiting times’ standard for early intervention in psychosis to extend the prevention of psychosis across England. Unfortunately, early intervention and early detection services are still not uniformly distributed in the UK, leaving gaps in service provision. The aim of this paper is to provide a business case model that can guide clinicians and services looking to set up or expand early detection services in their area. The paper also focuses on some existing models of care within the Pan-London Network for Psychosis Prevention teams.
Poverty in adolescence and later drug use disorders: understanding the mediation and interaction effects of other psychiatric disorders
Authors: Manhica Hélio , Straatmann Viviane S. , Lundin Andreas , Agardh Emilie , Danielsson Anna-Karin 
Published: March 2022

BackgroundPoverty in adolescence is associated with later drug use. Few studies have evaluated the role of adolescent psychiatric disorders in this association.AimsThis study aimed to investigate mediation and interaction simultaneously, enabling the disentanglement of the role of adolescent psychiatric disorders in the association between poverty in adolescent and later drug use disorders.MethodA national cohort study of 634 223 individuals born in 1985–1990, residing in Sweden between the ages of 13 and 18 years, was followed from age 19 years until the first in-patient or out-patient care visit with a diagnosis of drug use disorder. A four-way decomposition method was used to determine the total effect of the association with poverty and possible mediation by and/or interaction with diagnosis of adolescent psychiatric disorders.ResultsThe hazard ratios for drug use disorders among those experiencing poverty compared with those ‘never in poverty’ were 1.40 (95% CI, 1.32–1.63) in females and 1.43 (95% CI, 1.37–1.49) in males, after adjusting for domicile, origin and parental psychiatric disorders. Twenty-four per cent of this association in females, and 13% in males, was explained by interaction with and/or mediation by adolescent psychiatric disorders.ConclusionsPart of the association between poverty in adolescence and later drug use disorders was due to mediation by and/or interaction with psychiatric disorders. Narrowing socioeconomic inequalities in adolescence might help to reduce the risks of later drug use disorders. Interventions aimed at adolescents with psychiatric disorders might be especially important.
Long-Term Longitudinal Patterns of Patient-Reported Fatigue After Breast Cancer: A Group-Based Trajectory Analysis
Authors: Vaz-Luis Ines , Di Meglio Antonio , Havas Julie , El-Mouhebb Mayssam , Lapidari Pietro , Presti Daniele , Soldato Davide , Pistilli Barbara , Dumas Agnes , Menvielle Gwenn , Charles Cecile , Everhard Sibille , Martin Anne-Laure , Cottu Paul H. , Lerebours Florence , Coutant Charles , Dauchy Sarah , Delaloge Suzette , Lin Nancy U. , Ganz Patricia A. , Partridge Ann H. , André Fabrice , Michiels Stefan 
Published: March 2022

PURPOSE Fatigue is recognized as one of the most burdensome and long-lasting adverse effects of cancer and cancer treatment. We aimed to characterize long-term fatigue trajectories among breast cancer survivors. METHODS We performed a detailed longitudinal analysis of fatigue using a large ongoing national prospective clinical study (CANcer TOxicity, ClinicalTrials.gov identifier: NCT01993498 ) of patients with stage I-III breast cancer treated from 2012 to 2015. Fatigue was assessed at diagnosis and year 1, 2, and 4 postdiagnosis. Baseline clinical, sociodemographic, behavioral, tumor-related, and treatment-related characteristics were available. Trajectories of fatigue and risk factors of trajectory-group membership were identified by iterative estimates of group-based trajectory models. RESULTS Three trajectory groups were identified for severe global fatigue (n = 4,173). Twenty-one percent of patients were in the high-risk group, having risk estimates of severe global fatigue of 94.8% (95% CI, 86.6 to 100.0) at diagnosis and 64.6% (95% CI, 59.2 to 70.1) at year 4; 19% of patients clustered in the deteriorating group with risk estimates of severe global fatigue of 13.8% (95% CI, 6.7 to 20.9) at diagnosis and 64.5% (95% CI, 57.3 to 71.8) at year 4; 60% were in the low-risk group with risk estimates of 3.6% (95% CI, 2.5 to 4.7) at diagnosis and 9.6% (95% CI, 7.5 to 11.7) at year 4. The distinct dimensions of fatigue clustered in different trajectory groups than those identified by severe global fatigue, being differentially affected by sociodemographic, clinical, and treatment-related factors. CONCLUSION Our findings highlight the multidimensional nature of cancer-related fatigue and the complexity of its risk factors. This study helps to identify patients with increased risk of severe fatigue and to inform personalized interventions to ameliorate this problem.
Adjuvant Versus Early Salvage Radiation Therapy After Radical Prostatectomy for pN1 Prostate Cancer and the Risk of Death
Authors: Tilki Derya , Chen Ming-Hui , Wu Jing , Huland Hartwig , Graefen Markus , D'Amico Anthony V. 
Published: March 2022

PURPOSEAn association with a reduction in the risk of all-cause mortality (ACM) and the use of adjuvant as compared with early postradical prostatectomy salvage radiation therapy (sRT) in men with pN1 prostate cancer (PC) has been observed. Yet, whether this finding applies irrespective of the number of positive lymph nodes (LNs) after adjusting for the time-dependent use and duration of androgen deprivation therapy is unknown and is addressed in the current study.METHODSUnivariable and multivariable Cox regression was used to evaluate whether the ACM risk ratio for time-dependent use of adjuvant versus early sRT per unit increase in positive pelvic LNs was significantly reduced. Adjusted ACM estimates were calculated among men who received adjuvant, early salvage, or no RT stratified by one to three or four or more positive pelvic LNs.RESULTSAfter a median follow-up of 7.02 years, 986 (5.50%) men died, with 223 (22.62%) of PC. Adjuvant compared with early sRT was associated with a significantly lower ACM risk per unit increase in positive pelvic LNs (adjusted hazard ratio: 0.92; 95% CI, 0.85 to 0.99; P = .03). A significant difference in the 7-year adjusted ACM estimates favoring aRT versus early sRT was observed in men with four or more positive LNs (7.74% v 23.36%) in that the 95% CI for the 15.62% difference (5.90 to 25.35) excluded 0.00, but this was not true for men with 1-3 positive LNs (14.27% v 13.89%; 95% CI for the 0.38% difference [–7.02 to 7.79]).CONCLUSIONAdjuvant compared with early sRT in men with pN1 PC was associated with a decreased ACM risk, and this reduction increased with each additional positive pelvic LN.
Implementation and Feasibility of an Electronic Health Record–Integrated Patient-Reported Outcomes Symptom and Needs Monitoring Pilot in Ambulatory Oncology
Authors: Penedo Frank J. , Medina Heidy N. , Moreno Patricia I. , Sookdeo Vandana , Natori Akina , Boland Cody , Schlumbrecht Matthew P. , Calfa Carmen , MacIntyre Jessica , Crane Tracy E. , Garcia Sofia F. 
Published: March 2022

PURPOSE: Describe the feasibility and implementation of an electronic health record (EHR)–integrated symptom and needs screening and referral system in a diverse racial/ethnic patient population in ambulatory oncology. METHODS: Data were collected from an ambulatory oncology clinic at the University of Miami Health System from October 2019 to January 2021. Guided by a Patient Advisory Board and the Exploration, Preparation, Implementation, and Sustainment model, My Wellness Check was developed to assess physical and psychologic symptoms and needs of ambulatory oncology patients before appointments to triage them to supportive services when elevated symptoms (eg, depression), barriers to care (eg, transportation and childcare), and nutritional needs were identified. Patients were assigned assessments at each appointment no more than once in a 30-day period starting at the second visit. Assessments were available in English and Spanish to serve the needs of the predominantly Spanish-speaking Hispanic/Latino population. RESULTS: From 1,232 assigned assessments, more than half (n = 739 assessments; 60.0%) were initiated by 506 unique patients. A total of 65.4% of English and 49.9% of Spanish assessments were initiated. Among all initiated assessments, the majority (85.1%) were completed at home via the patient portal. The most common endorsed items were nutritional needs (32.9%), followed by emotional symptoms (ie, depression and anxiety; 27.8%), practical needs (eg, financial concerns; 21.7%), and physical symptoms (17.6%). Across the physical symptom, social work, and nutrition-related alerts, 77.1%, 99.7%, and 78.8%, were addressed, respectively, by the corresponding oncology health professional, social work team member, or nutritionist. CONCLUSION: The results demonstrate encouraging feasibility and initial acceptability of implementing an EHR-integrated symptom and needs screening and referral system among diverse oncology patients. To our knowledge, this is the first EHR-integrated symptom and needs screening system implemented in routine oncology care for Spanish-speaking Hispanics/Latinos.