bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crying does not alleviate acute pain perception: Evidence from an experimental study
Authors: Gračanin Asmir , Hendriks Michelle C. P. , Vingerhoets Ad J. J. M. 
Published: May 2022

AbstractBackgroundWhereas previous studies revealed positive effects of emotional expressions such as swearing and laughing on acute pain, systematic research on the effects of crying on pain is missing. The rationale for the current study is that either a mere emotional distraction or changes in oxytocin and opioid levels represent a mechanism through which crying modulates pain, with the timing of mood changes as crucial information for distinguishing between potential mechanisms.MethodsIn two studies, we exposed participants (Study 1:n = 57; Study 2:n = 70) to a sad movie and measured their mood, and exposed them to pain induction procedures (electric shock and cold‐pressor test, respectively) before and after the film. Dependent variables were pain threshold, tolerance, and intensity. In addition to baseline and one immediate post‐crying mood and pain response measurement in both studies, in Study 2, we repeated these procedures 20 and 50 min later to discern between the potential role of neurobiological substances and distraction.ResultsCrying was elicited in 28 participants in Study 1 (49.1%) and 49 (70%) in Study 2. We found no systematic differences in pain and mood changes between criers and non‐criers and no systematic dose‐response relationship between crying and pain responses and mood. The only significant effects ran contrary to our hypotheses, showing detrimental effects of the occurrence (Study 1) and frequency of crying (both studies) on pain threshold.ConclusionsResults do not support the idea that crying has pain‐alleviating effects, either via distraction or direct biological mechanisms.SignificanceDespite previous findings on pain alleviating effects of emotional expression and the widespread idea about the generally beneficial consequences of emotional crying, research on the possible pain alleviating effects of crying is largely missing. Two quasi‐experimental studies demonstrated that crying induced in laboratory conditions does not alleviate acute pain responses, suggesting that role of crying in pain interventions is doubtful. Less directly, results cast light on the role of emotional distraction from acute pain and possible crying‐related neurochemical changes.
Development and validation of capillary zone electrophoresis and high‐performance liquid chromatography methods for the determination of oral anticoagulant edoxaban in pharmaceutical tablets
Authors: Oliveira Rocha Manoelly , Bordignon Primieri Gabriele , Ribeiro Wingert Nathalie , Arguello Da Silva Jacqueline , Steppe Martin 
Published: May 2022

AbstractThe incidence of thrombotic complications in SARS‐CoV‐2 infections has become a global concern; thus, anticoagulants are an integral part of the treatment. Edoxaban (EDX) is an oral anticoagulant suitable for pharmacologic thromboprophylaxis. Herein, two novel analytical methods for EDX determination in tablets are developed and validated using capillary zone electrophoresis (CZE) and high‐performance liquid chromatography (HPLC). Operating conditions such as the electrolyte's concentration and pH value, injection time, volume, and the capillary temperature, were optimized. The methods were successfully validated by establishing the linearity, intra‐ and inter‐day precisions (relative standard deviation [%]), accuracy, and robustness. Adequate separation of excipients and degradation products of EDX generated by stress degradation conditions demonstrated the stability‐indicating capability of the methods. The analytical procedures were linear in the range of 25–125 µg/ml (r > 0.999), with the limits of detection and quantification of 3.26 and 10.87 µg/ml for CZE and 0.740 and 2.78 µg/ml for HPLC. Although both methodologies are suitable for determining EDX in tablets, CZE provides a greener alternative due to low‐cost analysis using less organic solvents and minimizing waste generation.
Intersection between environmental data science and the R community in Latin America
Authors: da Silva Natalia 
Published: May 2022

AbstractEnvironmental data science is used to solve environmental problems, and to help answer complex questions about biodiversity loss, climate change, and water scarcity, among others thereby allowing sustainable decision‐making using data‐driven approaches. In this opinion piece, I describe some recent Latin American experiences in the data science community, and what is needed for environmental data scientists to take advantage of those experiences. Specifically, I show the importance of being part of a diverse and local data science community.
ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma
Authors: Han Rachel , Dermawan Josephine K. , Demicco Elizabeth G. , Ferguson Peter C. , Griffin Anthony M. , Swanson David , Antonescu Cristina R. , Dickson Brendan C. 
Published: May 2022

AbstractSpindle cell rhabdomyosarcoma represents a rare neoplasm characterized by monomorphic spindle cells with a fascicular architecture and variable skeletal muscle differentiation. Following incidental identification of a ZFP64::NCOA3 gene fusion in an unclassified spindle cell sarcoma resembling adult‐type fibrosarcoma, we performed a retrospective archival review and identified four additional cases with a similar histology and identical gene fusion. All tumors arose in adult males (28–71 years). The neoplasms were found in the deep soft tissues, two were gluteal, and one each arose in the thigh, abdominal wall, and chest wall. Morphologically, the tumors were characterized by spindle cells with a distinctive herringbone pattern and variable collagenous to myxoid stroma. The nuclei were relatively monomorphic with variable mitotic activity. Three tumors had immunoreactivity for MyoD1, and four contained variable expression of desmin and smooth muscle actin. All cases tested for myogenin, CD34, S100, pankeratin, and epithelial membrane antigen were negative. Targeted RNA sequencing revealed a ZFP64::NCOA3 fusion product in all five tumors. Three patients developed distant metastases, and two ultimately succumbed to their disease within 2 years of initial diagnosis. This study suggests ZFP64::NCOA3 fusions define a novel subtype of rhabdomyosarcoma with a spindle cell morphology and aggressive clinical behavior. The potential for morphologic and immunohistochemical overlap with several other sarcoma types underscores the value of molecular testing as a diagnostic adjunct to ensure accurate classification and management of these neoplasms.
Risk perceptions and risk‐averse attitude influenced older patients' first‐diagnosis‐seeking behaviour at tertiary hospitals
Authors: Ruan Yuhui , Dai Yaqi , Zhu Demi 
Published: May 2022

AbstractObjectiveThis qualitative study aimed to investigate the associations of older patients' inappropriate healthcare‐seeking behaviour at tertiary hospitals in China with their risk perceptions and attitude.MethodsThe study was based on nine focus group interviews (involving 41 older patients, with three to six per group) and involved the grounded theory method. The participants were recruited at tertiary hospitals.ResultsThe results of this study showed that older patients' inappropriate first‐diagnosis‐seeking behaviour at tertiary hospitals was impacted by their risk perceptions and risk‐averse attitude. Both external factors (family/friends and the Internet) and internal factors (preferences and habits) had played important roles in related processes.ConclusionThus, to guide older patients' healthcare‐seeking behaviour, changing the thoughts and behaviour of the older patients themselves, their spouses, adult children, other relatives, and friends are all important. More attention should be paid on guiding appropriate risk perceptions and attitude regarding lower‐level medical institutions, increasing their preferences and habit formation regarding lower‐level medical institutions, enhancing older patients' social support and improving and standardising online health information. These are important for the future development of the hierarchical medical system in China.
Comparison of three different numerical implementations to model rainfall‐runoff transformation on roofs
Authors: Sañudo Esteban , Cea Luis , Puertas Jerónimo 
Published: May 2022

AbstractRoofs represent a high percentage of the impervious surfaces in urban areas, and hence their implementation in urban drainage models is essential for accurate results to be achieved. Current modelling approaches are based on parameters such as a roof's slope and width, its roughness coefficient, and the initial abstraction. In this study, an experimental campaign was performed in order to assess the sensitivity of the roof runoff hydrographs to these parameters. The experimental tests were carried out in a new large‐scale urban drainage facility equipped with a rainfall simulator. The experimental tests were replicated numerically using three different levels of model resolution, from a high fidelity representation with a spatial resolution of 5 mm (which can be considered a digital twin) to a lumped representation. Our experimental results show that, for practical purposes, the sensitivity of the outlet runoff hydrograph to the roof slope tested is negligible. The numerical upscaling analysis carried out showed that flat roofs present a slightly different hydrograph behaviour with greater times of concentration than sloped roofs. No significant sensitivity of the outlet hydrograph to the surface roughness coefficient was found. In terms of numerical modelling, the use of a very high spatial resolution for the roof, which implies a high computational cost, does not affect the results significantly compared to the far simpler lumped approach. The current research involves the first thorough experimental and computational analysis of the runoff over roofs to date.
Effect of sex education on sexual function and sexual quality of life in women with endometriosis: A quasi‐experimental study
Authors: Matloobi Maryam , Amini Leila , Shahali Shadab , Haghani Hamid , Tahermanesh Kobra , Hassanlouei Babak , Allahqoli Leila , Alkatout Ibrahim 
Published: May 2022

AbstractObjectiveTo evaluate the effect of a sex education program on sexual function and sexual quality of life in women with endometriosis.MethodsIn a quasi‐experimental study, women with endometriosis who had undergone laparoscopic surgery were assigned to an intervention group (n = 36) or a control group (n = 36). The intervention group received a sex education program consisting of two sessions a week (90 min each) for two consecutive weeks; the control group received none. Both groups were followed for 12 weeks. Sexual function and sexual quality of life were assessed on the Female Sexual Function Index (FSFI) and the Sexual Quality of life‐Female (SQOL‐F) questionnaire before the intervention, as well as 8 and 12 weeks after the intervention. Outcomes were analyzed using Student t test, the χ2 test, Fisher exact test, and repeated measures analysis of variance.ResultsThe mean age of the study participants was 36.9 ± 5.7 years. The two groups did not differ significantly in terms of demographics and pre‐intervention clinical characteristics. At the end of the study, sex education reduced female sexual dysfunction by 58.1% in the intervention group. The mean FSFI score increased significantly in the intervention group from pre‐intervention to 8 and 12 weeks post‐intervention compared with the scores in the control group (P < 0.001).ConclusionsSex education appears to be a promising intervention for reducing sexual dysfunction and improving sexual function and sexual quality of life in women with endometriosis. Future studies should encompass longer periods of follow up to obtain further data on the efficacy of sex education in this setting.
Adenomyosis decreases the live birth rate but may not affect perinatal outcomes in assisted reproductive cycles
Authors: Trinchant Rafael , Cruz María , Requena Antonio 
Published: May 2022

AbstractObjectiveTo determine if uterine adenomyosis is associated with worse perinatal outcomes in ovum donation assisted reproductive treatment cycles.Materials and MethodsA multicenter and retrospective cohort study in which a total of 3307 patients undergoing an ovum donation cycle in 2018–2019 were included and divided into two groups: adenomyosis (n = 179) and controls (n = 3128). Clinical, obstetrical, and perinatal outcomes were analyzed.ResultsA lower live birth rate per embryo transfer was observed in women diagnosed with adenomyosis versus control women: 67/179 (37%) versus 1560/3128 (49.9%), respectively (odds ratio 0.6, 95% confidence interval 0.43–0.83, P = 0.002). There was no statistically significant difference in childbirth delivery method (vaginal versus cesarean section) between the adenomyosis and control groups. Mean gestational age at the time of delivery, newborn length and weight, and incidences of low birth weight, preterm birth, and admission to the neonatal intensive care unit did not differ between the two groups. In addition, in vitro fertilization and perinatal outcomes were similar in patients with diffuse compared with focal adenomyosis.ConclusionsAdenomyosis affects clinical but may not affect perinatal outcomes in ovum donation cycles.
The protective effects of thymol and carvacrol against di (2‐ethylhexyl) phthalate‐induced cytotoxicity in HEK‐293 cells
Authors: Amara Ines , Timoumi Rim , Annabi Emna , Ben Othmène Yosra , Abid‐Essefi Salwa 
Published: May 2022

AbstractThe protective effects of thymol and carvacrol, two phenolic monoterpenes with a wide spectrum of pharmacological effects, against the oxidative stress produced by the di (2‐ethylhexyl) phthalate (DEHP) in human embryonic kidney cells 293 cells (HEK‐293 cells) were investigated in this study. The cytotoxicity was monitored by cell viability, while oxidative stress generation was assessed by reactive oxygen species (ROS) quantification, antioxidant enzyme activities measurement, glutathione concentration, and malondialdehyde (MDA) quantification. The genotoxicity was evaluated by the measurement of DNA fragmentation through the Comet assay. Our results demonstrated that the pretreatment of HEK‐293 cells with thymol or carvacrol, 2 h before DEHP exposure, significantly increased the cell viability, decreased the ROS overproduction, modulated catalase (CAT), and superoxide dismutase (SOD) activities, restored the reduced glutathione content, and reduced the MDA level. The DNA fragmentation was also decreased by thymol and carvacrol pretreatment. These findings suggest that thymol and carvacrol could protect HEK‐293 cells from DEHP‐induced oxidative stress.
Development and testing of an algorithm for efficient MP2/CCSD(T) energy estimation of molecular clusters with the 2–body approach
Authors: Khire Subodh S. , Gadre Shridhar R. 
Published: May 2022

AbstractThis work reports the development and testing of an automated algorithm for estimating the energies of weakly bound molecular clusters employing correlated theory. Firstly, the monomers and dimers of (homo/hetero) clusters are identified, and the sum of one‐body and two‐body contributions to correlation energy is calculated. The addition of this contribution to the Hartree‐Fock full calculation (FC) energies provides a good estimate of the total energies at Møller–Plesset second‐order perturbation theory (MP2)/coupled‐cluster method with singles and doubles (CCSD) (T)‐level theory using augmented Dunning basis sets. The estimated energies for several test clusters show an excellent agreement with their FC counterparts, with a substantial wall‐clock time saving employing off‐the‐shelf hardware. Furthermore, the complete basis set (CBS) limit for MP2 energy computed using the two‐body approach also agrees with its CBS energy with its FC counterpart.
Utilizing a CBPR approach to assess the impact of COVID‐19 on individuals who receive publicly funded behavioral health services
Authors: Grant Nickholas , Byrd Ronald , Forlano Robert , Olsen Steven , Youins Richard , Sernyak Michael J. , Fulara Doreen , Kaufman Joy S. 
Published: May 2022

AbstractThe coronavirus disease pandemic has highlighted significant gaps in community mental health services, placing vulnerable individuals at greater risk for mental health and substance use difficulties via disrupting their wellness journey. Guided by a wellness framework, a needs assessment was conducted among adult consumers of behavioral health services to understand their needs during the pandemic and to help develop and strengthen service delivery strategies. A team of three university researchers and four Consumer Researchers, who receive services at a publicly funded community mental health center, engaged in a community‐based participatory project in which 13 focus groups were conducted with 51 consumers. Several themes emerged from a thematic analysis of transcripts regarding consumer well‐being and healthcare needs, coping strategies employed, and the accessibility, benefits, and perception of clinical and support services during the pandemic. Results highlighted strengths in service delivery and areas in need of enhancement. Findings may inform similar community services that seek to enhance delivery of care among vulnerable populations.
The impact of clinical decision support systems on provider behavior in the inpatient setting: A systematic review and meta‐analysis
Authors: Ronan Clare E. , Crable Erika L. , Drainoni Mari‐Lynn , Walkey Allan J. 
Published: May 2022

AbstractBackgroundClinical decision support systems (CDSS) are used to improve processes of care. CDSS proliferation may have unintended consequences impacting effectiveness.ObjectiveTo evaluate the effectiveness of CDSS in altering clinician behavior.DesignElectronic searches were performed in EMBASE, PubMed, and Cochrane Central Register of Control Trials for randomized controlled trials testing the impacted of CDSS on clinician behavior from 2000–2021. Extracted data included study design, CDSS attributed and outcomes, user characteristics, settings, and risk of bias. Eligible studies were analyzed qualitatively to describe CDSS types. Studies with sufficient outcome data were included in the meta‐analysis.Setting and ParticipantsAdult inpatients in the United States.InterventionClinical decision support system versus non‐clinical decision support system.Main Outcome and MeasureA random‐effects model measured the pooled risk difference (RD) and odds ratio of clinicians' adherence to CDSS; subgroup analyses tested differences in CDSS effectiveness over time and by CDSS type.ResultsQualitative synthesis included 22 studies. Eleven studies reported sufficient outcome data for inclusion in the meta‐analysis. CDSS did not result in a statistically significant increase in clinician adoption of desired practicies (RD = 0.04 [95% confidence interval {CI} 0.00, 0.07]). CDSS from 2010‐2015 (n = 5) did not increase clinician adoption of desired practice [RD –0.01, (95% CI –0.04, 0.02)].CDSS from 2016‐2021 (n = 6) were associated with an increase in targeted practices [RD 0.07 (95% CI0.03, 0.12)], pInteraction = 0.004. EHR [RD 0.04 (95% CI 0.00, 0.08)] vs. non‐EHR [RD 0.01 (95% CI –0.01, 0.04)] based CDSS interventions did not result in different adoption of desired practices (pInteraction = 0.27). The meta‐analysis did not find an overall positive impact of CDSS on clinician behavior in the inpatient setting.
Snow and land use alter pheasant survival in South Dakota
Authors: Kauth Hilary R. , Gregory Andrew J. , Kauth Adam J. , Harsh Sprih , Runia Travis J. , Lonsinger Robert C. 
Published: May 2022

AbstractWe examined survival of ring‐necked pheasants (Phasianus colchicus) occupying fragmented landscapes within the Prairie Pothole Region in South Dakota, USA, where severe winter weather events historically limited pheasant population growth through increased mortality. Recent landscape transformations could further affect overwinter adult female survival by reducing critical winter resources. Assessing the influence of time‐dependent landscape features on survival at small focal scales may reveal spatially important relationships. We captured and monitored 321 adult female pheasants from 2017–2019 and recorded 110 pheasant winter mortalities. Female pheasant winter survival was 0.66 (85% CI = 0.62–0.70) and was inversely correlated to snow depth. We generated Cox proportional hazard models to determine risk of mortality associated with landscape features. Pheasants using landscapes other than perennial cover (i.e., emergent wetland, tall vegetation, woody, food plots) experienced a 2.22 times greater risk of raptor predation than pheasants using perennial cover. Additionally, pheasants experienced a 58% reduced risk of weather mortality when using emergent wetlands. We analyzed resource selection ratios to understand how perceived landscape risks at the population level scaled down to land use selection at the individual level. Female pheasants selected for emergent wetlands, showed no selection for woody features, and avoided tall vegetation (non‐aquatic herbaceous vegetation >75 cm) during severe winters. Pheasants would greatly benefit from conservation of emergent wetlands and integrating perennial cover into harvested cropland.
Human activities have markedly altered the pattern and trend of net primary production in the Ili River basin of Northwest China under current climate change
Authors: Zhang Fuguang , Zeng Biao , Cao Ying , Li Fang , Tang Zhengyu , Qi Jiaguo 
Published: May 2022

AbstractThe Ili River basin (IRB), as an epitome of border areas of Northwest China and has experienced intensive human disturbance since the implementation of the Western Development Strategy in 2000. However, the ways that human activity affected the pattern and trend of net primary production (NPP) in this region under current rapid climate change remain unclear. Here, potential NPP time‐series data, driven solely by climate change, were simulated using a process‐based model IBISi, with an initial status that was already disturbed by human activity prior to the measurement period. The human impacts on NPP during the measurement period were derived by comparing potential NPP with remotely‐sensed ones. The results indicate that human activities have markedly altered the pattern and trend of NPP in the IRB during 2000–2017. Cropland reclamation and cultivation, and afforestation, have resulted in significant increases in NPP relative to their typically low values in the basin bottom areas. Associated with those changes grazing has caused negative deviations in most grasslands with potentially high NPP. As a consequence, the spatial heterogeneity of NPP was significantly lowered. A slight decreasing trend in NPP of the IRB was revealed by remote sensing, which contrasted the increasing trend that should have occurred due to climate change. This difference between the real and simulated trends was mainly attributed to a weakening of positive human impacts on NPP in croplands and strengthening of negative impacts in grasslands. These findings provide valuable information for current land‐use management and ecosystem restoration in Northwest China and Central Asia.