bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Connection Between Opioid Withdrawal and Takotsubo Cardiomyopathy: Case Reports of ‘Opioid Octopus Heart’
Authors: Hack Benjamin , Ojeniyi Solabomi , Mamzhi Yakov , Bou-Saba Adeeb G , Saade Louis 
Published: January 2022

Introduction Takotsubo Cardiomyopathy (TCM) is an incompletely understood diagnosis. The leading hypothesis of its pathogenesis is that a hyperadrenergic state leads to cardiotoxicity, which is supported by case findings. Withdrawal from opioids is one potential etiology of an excessive adrenergic response and, therefore, may precipitate TCM. Case Presentations Here, we present 2 cases of TCM in patients who chronically used opioids, both at the same institution within 1 month of each other. The first patient is a 68-year-old man who presented with a chronic obstructive pulmonary disease exacerbation and did not disclose his long-standing opioid use disorder. One day after admission, he was found to be in opioid withdrawal and, soon after, developed TCM. He was originally treated for non-ST elevation myocardial infarction and opioid withdrawal but decompensated. He was sent to the intensive care unit (ICU) to receive pressors and fluid resuscitation. He soon recovered and his cardiac function returned to baseline. The second patient is a 33-year-old woman with opioid use disorder taking methadone who presented with lower extremity weakness, edema, and pain. She was diagnosed with infective endocarditis. While awaiting surgery and receiving antibiotics, she developed respiratory failure and was upgraded to the ICU. There was a lapse in her opioid treatment, and she subsequently developed TCM. She was treated with pressors and fluids in the ICU, and eventually recovered with reduced cardiac function at the time of discharge. Conclusions While clinical evidence indicated opioid withdrawal as the likely provoking factor for development of TCM in the first case, the second patient’s symptoms from other clinical complications confounded the cause of her TCM. Twelve similar cases have been reported in the literature, suggesting that opioid withdrawal may be associated with development of TCM. Further quantitative research is required to establish this relationship. Our findings contribute to the theoretical pathophysiology of TCM and offer important considerations for clinical management of opioid withdrawal.
Research on the effect of fenugreek seed powder on the quality indicators of ryewheat bread
Authors: Бакуменко Олеся Евгеньевна , Алексеенко Елена Викторовна , Некрасова Элла Игоревна , Гильмиярова Ольга Дмитриевна 
Published: January 2022

В статье приведена характеристика обогащающих ингредиентов (гороховой клетчатки «EmfibreEF 200», настоя семени льна, плодов жимолости, семян пажитника, конопляной муки) - источников пищевых волокон, применяемых в хлебопекарном производстве. Проведен выбор семян пажитника, как обогащающего ингредиента с повышенным содержанием пищевых волокон, способных оказать положительное влияние на организм человека. Дана характеристика порошка семян пажитника по влагоудерживающей и водопоглотительной способности. Исследована способность порошка из семян пажитника связывать ионы «тяжелых» металлов (на примере ионов меди). Определен способ внесения, обоснована дозировка порошка из семян пажитника и изучено его влияние на показатели качества ржано-пшеничного хлеба.
The article describes the characteristics of enriching ingredients (pea fiber «EmfibreEF 200», flax seed infusion, honeysuckle fruits, fenugreek seeds, hemp flour) - sources of dietary fiber used in baking. The selection of fenugreek was as an enriching ingredient with a high content of dietary fiber, that can have a positive effect on the human body. The characteristics of fenugreek seed powder in terms of water-retaining and water-absorbing capacities are given. The ability of powder from fenugreek seeds to bind ions of «heavy» metals (for example, copper ions) has been investigated. The method of application was determined and the dosage of fenugreek seed powder was substantiated, studied its influence on the quality indicators of rye-wheat bread.
Antimicrobial potential of the Lactococcus and Lactobacillus microorganisms
Authors: Мельникова Елена Ивановна , Богданова Екатерина Викторовна , Павельева Дарья Анатольевна 
Published: January 2022

В работе описаны перспективы использования биозащитных культур при производстве продуктов питания для сохранения их качества и безопасности с целью сокращения пищевых отходов. Проанализированы основные механизмы действия и оценен антимикробный биозащитный потенциал некоторых штаммов лактококков и лактобактерий, приведены способы ингибирования контаминантов продуцированными метаболитами молочнокислых бактерий (органическими кислотами, альдегидами, кетонами, перекисями и др.). Приведен и описан механизм действия бактериоцинов, проявляющих антагонистическую активность. В заключение оценена перспектива использования биозащитных культур для увеличения сроков годности пищевых продуктов, доказано их преимущество в сравнении с химическими консервантами.
The paper describes the prospects for the usage of bioprotective crops in the production of food products to preserve their quality and safety aimed to reduce food waste. The main mechanisms of action were analyzed. The antimicrobial bioprotective potential of some strains of Lactococcus and Lactobacillus was evaluated. The methods of inhibiting contaminants produced by metabolites of lactic acid bacteria (organic acids, aldehydes, ketones, peroxides, etc.) were presented. The mechanism of action of bacteriocins exhibiting antagonistic activity was presented and described. The prospect of using bioprotective cultures to increase the shelf life of food products was evaluated in conclusion. Their advantage was proved in comparison with chemical preservatives.
Dampak Perusahaan Perkebunan Kelapa Sawit Terhadap Perubahan Kebudayaan Masyarakat Desa Pasar Minggu Kecamatan Maro Sebo Kabupaten Muaro Jambi Provinsi Jambi
Authors: Leonik  , Anwar US Kasful 
Published: January 2022

Penelitian ini bertujuan untuk mendeskripsikan perubahan kebudayaan yang terjadi di daerah penelitian terkait dengan keberadaan perusahaan perkebunan kelapa sawit di Desa Pasar Minggu. Penentuan lokasi penelitian dilakukan secara sengaja (Purpossive).Pengumpulan data dalam penelitian ini terdiri dari data primer dan data sekunder.Untuk mendapatkan data yang lebih mendalam dilakukan wawancara mendalam (In-depht interview) serta menggunakan teknik bola salju (Snowball).Berdasarkan metode yang digunakan, hasil penelitian menunjukkan bahwa terjadinya perubahan kebudayaan masyarakat Desa Pasar Minggu Kecamatan Maro Sebo Kabupaten Muaro Jambi Provinsi Jambi. Perubahan itu di mulai dari perubahan mata pencaharian masyarakat yang kemudian proses inovasi, difusi, dan integrasi mempengaruhi unsur-unsur kebudayaan masyarakat di Desa Pasar Minggu yaitu sistem peralatan hidup,sistem kepercayaan, organisasi sosial, kesenian,bahasa, dan sistem pengetahuan.Keberadaan perusahaan perkebunan kelapa sawit PT. Batang Hari Sawit Sejahtera (BSS), Kertapersada di Desa Pasar Minggu juga menimbulkan dampak terhadap masyarakat Desa Pasar minggu, baik itu dampak positif maupun dampak negatif. Dampak positif seperti kesempatan kerja, peluang berusaha, peningkatan pendapatan masyarakat, bantuan pendidikan, serta betambah dan berkembangnya organisasi di masyarakat. Sedangkan dampak negatifnya persaingan untuk mendapatkan pekerjaan yang lebih layak di perusahaan antara masyarakat Desa Pasar Minggu dengan pendatang. Tidak hanya itu, mudahnya arus informasi masuk dan bertambahnya penduduk menjadikan masyarakat yang heterogen sehingga pengaruh narkoba dan sabu-sabu sangat mudah mempengaruhi dan akhirnya digunakan masyarakat terutama Pemuda Pasar Minggu.
Changes in Intraocular Pressure (IOP) after Phacoemulsification in Eyes with Occludable Angle Of Anterior Chamber
Authors: Sahu Pramod Kumar , Das Gopal Krushna , Jain Divya , Madan Siddharth 
Published: January 2022

Purpose:
The study was aimed to evaluate changes in intraocular pressure (IOP) after phacoemulsification in eyes with occludable angle of anterior chamber and compare the results with eyes having open angle in patients without previously diagnosed glaucoma.

Methods:
Study subjects were cataract patients scheduled for phacoemulsification, having open or occludable angles. The patients were divided into two groups of 30 eyes each, having open angle and occludable angles after evaluation by gonioscopy. A total of 60 eyes that underwent phacoemulsification were analyzed on post-operative day 1, day 7, day 30 and day 90. Outcome measures included estimation of visual acuity, IOP and central corneal thickness.

Results:
The two groups showed significant reduction in IOP (p<0.05) after phacoemulsification. Increase in IOP was observed at day 7 but thereafter there was a gradual reduction in IOP throughout 12 weeks of follow-up period in both the groups. The mean reduction in IOP in Group I with occludable angles was 1.9 mm of Hg (8.3%) and in Group II was 1.4 mm of Hg (6.3%). Comparison between two groups has not shown any significant difference in terms of IOP reduction.

Conclusions:
Removal of the cataract using phacoemulsification serves as a modality to decrease IOP in eyes showing borderline raised IOP. We observed that the eyes with occludable angle showed a higher reduction in IOP levels after cataract surgery as compared to the open angle group. However, both the groups demonstrated a significant reduction in IOP in the follow-up period. Phacoemulsification does have a role in reduction of IOP which may affect the long-term prognosis in the management of glaucoma with cataract.
A hybrid science‐guided machine learning approach for modeling chemical processes: A review
Authors: Sharma Niket , Liu Y. A. 
Published: January 2022

AbstractThis study presents a broad perspective of hybrid process modeling combining the scientific knowledge and data analytics in bioprocessing and chemical engineering with a science‐guided machine learning (SGML) approach. We divide the approach into two major categories: ML complements science, and science complements ML. We review the literature relating to the hybrid SGML approach, and propose a systematic classification of hybrid SGML models. For applying ML to improve science‐based models, we present expositions of direct serial and parallel hybrid modeling and their combinations, inverse modeling, reduced‐order modeling, quantifying uncertainty in the process and even discovering governing equations of the process model. For applying scientific principles to improve ML models, we discuss the science‐guided design, learning and refinement. For each subcategory, we identify its requirements, strengths, and limitations, together with their published and potential applications. We also present several examples to illustrate different hybrid SGML methodologies for modeling chemical processes.
Linear quadratic nonzero‐sum stochastic differential game of a partially observed Markov jump linear systems
Authors: Wu Chengyu , Zhang Chengke , Yang Lu , Wang Tao 
Published: January 2022

AbstractIn this study, a partially observed linear quadratic (LQ) non‐cooperative stochastic differential game of Markov jump linear system (MJLS) is considered. First, a new proof of filtering theory is given, using the separation principle and filtering technology, partial observations can be transformed into complete observation. Second, nonzero‐sum stochastic differential game problem for MJLS are studied using the dynamic programming principle and completion square method. Then, the sufficient and necessary conditions for the Nash equilibrium are obtained. Finally, a numerical simulation is performed.
The impact of insecticides containing deltamethrin and cyfluthrin on the composition of surface compounds in the larvae, females and males of Tenebrio molitor
Authors: Wojciechowska Marta , Stepnowski Piotr , Gołębiowski Marek 
Published: January 2022

AbstractThis paper presents the effect of insecticides on the composition of the surface compounds of one of the most harmful insects, Tenebrio molitor, by analysis using GC–MS. As a result of the use of insecticides, the composition of the chemical compounds on the surface of insects changes, depending on the insecticides used. The most numerous groups of the marked compounds were fatty acids, alkanes, esters and sterols. The content of the identified compounds in the larvae increased at both 24 and 48 h after the application of insecticides, in comparison with the control samples. The content of identified compounds in the samples taken from the females increased 24, 48 and 72 h after the application of insecticides in comparison with the control samples. By contrast, in samples prepared from males, the content of identified compounds decreased 24 h after the application of insecticides, compared with the control samples. The highest content of chemical compounds was for fatty acids and alkanes after the use of insecticides. The content of fatty acids after the application of the insecticide with deltamethrin was 62.1 ± 3.3–466.9 ± 5.9 μg/g, and after the application of the insecticide with cyfluthrin was 49.9 ± 1.9–458.3 ± 4.2 μg/g. However, the content of alkanes after the use of deltamethrin was 115.6 ± 4.2–4672.0 ± 32.1 μg/g, and after the use of cyfluthrin was 189.4 ± 3.8–3975.0 ± 10.2 μg/g.
Secretory type II cGMP‐dependent protein kinase blocks activation of PDGFRβ via Ser254 in gastric cancer cells
Authors: Pang Ji , Li Guorui , Qian Hai , Wu Yan , Chen Yongchang 
Published: January 2022

AbstractThe study of secretory protein kinase is an emergent research field in recent years. The secretion phenomenon of type II cGMP‐dependent protein kinase (PKG II) was found in our latest research and our previous study confirmed that PKG II inhibited platelet‐derived growth factor receptor β (PDGFRβ) activation induced by platelet‐derived growth factor BB (PDGF‐BB) within the gastric cancer cells. Thus, this study was designed to investigated effect of secretory PKG II on PDGFRβ. Transwell assay and CCK8 assay indicated that secretory PKG II reversed PDGF‐BB‐induced cell migration, invasion, and proliferation. Immunoprecipitation, GST pull down and Western blotting results showed that secretory PKG II combined with extracellular domains of PDGFRβ and phosphorylated it, and thereby inhibited PDGF‐BB‐induced activation of PDGFRβ, and downstream PI3K/Akt and MAPK/ERK pathways. Mutation at Ser254 of PDGFRβ to alanine abolished the above inhibitory effects of secretory PKG II on PDGFRβ, indicating that Ser254 was the specific site phosphorylated by secretory PKG II. In conclusion, secretory PKG II inhibited PDGFRβ activation via Ser254 site.
Testosterone and dihydrotestosterone modulate the redox homeostasis of endothelium
Authors: Koukoulis George N. , Filiponi Maria , Gougoura Sofia , Befani Christina , Liakos Panagiotis , Bargiota Αlexandra 
Published: January 2022

AbstractThe predominance of cardiovascular diseases among men compared to premenopausal women has been attributed to testosterone, which is implicated in vascular remodeling. Molecular mechanisms underlying its role have not been clarified but oxidative stress‐induced inflammation may be important. We therefore investigated in vitro the effects of testosterone and dihydrotestosterone, (a nonaromatized androgen), on redox homeostasis in absence (basal conditions) and after corticotropin‐releasing hormone‐induced pro‐oxidant action in macroendothelial cells. More specifically, we explored their role on well‐established antioxidant enzymes activity, namely endothelial nitric oxide synthase, superoxide dismutase, catalase, and glutathione. We observed that both androgens significantly increased the intracellular reactive oxygen species levels, endothelial nitric oxide synthase activity, nitric oxide concentration as well as superoxide dismutase activity and decreased catalase activity. These effects of Testosterone and DHT were reversed in the presence of the androgen receptor antagonist, flutamide. Moreover, testosterone and dihydrotestosterone similarly enhanced the stimulatory effect of corticotropin‐releasing hormone on intracellular reactive oxygen species levels and superoxide dismutase activity but did not influence the inhibitory effect on endothelial nitric oxide synthase activity, nitric oxide release and catalase activity. Finally, androgens did not have a detectable effect on glutathione levels or the glutathione/glutathione plus glutathione disulfide ratio. Our results reveal that testosterone and DHT rise the intracellular redox threshold of the endothelial cell and increases NO synthesis. These findings suggest that the action of testosterone is affected by the redox status of the endothelium and help to explain its controversial effects on the cardiovascular system.
Contemporary treatment of below‐the‐knee peripheral arterial disease in patients with chronic limb threatening ischemia: Observations from the Vascular Quality Initiative
Authors: Singh Nikhil , Ding Li , Magee Gregory A. , Shavelle David M. 
Published: January 2022

AbstractObjectiveWe sought to determine trends in percutaneous transluminal angioplasty (PTA) versus non‐PTA interventions over time, as well as factors that influence the decision for non‐PTA intervention.BackgroundAlthough the optimal strategy for revascularization in patients with below‐the‐knee (BTK) chronic limb‐threatening ischemia (CLTI) remains under investigation, PTA has been the preferred endovascular approach. Recently, there has been an increase in the use of non‐PTA approaches for revascularization.MethodsWe performed a retrospective analysis of the Vascular Quality Initiative. Between 2011 and 2020, a total of 23,850 procedures corresponding to 33,098 arteries in 19,404 patients with CLTI were included. After application of exclusion criteria and removal of missing variables, 18,644 arteries were included in the study cohort. The primary analysis was factors associated with receiving non‐PTA intervention. Secondary analysis included trends in PTA versus non‐PTA intervention over time.ResultsThroughout the study period, the majority of interventions (72%) were PTA alone. The percentage of non‐PTA interventions, on a per‐artery basis, increased over the study period from 18% to 33%, p < 0.01. Advanced age, increasing TransAtlantic Inter‐Society Consensus classification, and concomitant above‐the‐knee disease were associated with an increased likelihood for non‐PTA intervention. In contrast, longer lesion length, insulin‐dependent diabetes mellitus, bilateral disease, and discharge to location other than home were associated with an increased likelihood of PTA.ConclusionsWe observed a significant increase in the percentage of non‐PTA interventions for patients with CLTI requiring BTK interventions over the last decade, with lesion‐ and patient‐specific characteristics associated with the type of endovascular approach.
Incidence and predictors of cardiogenic shock following surgical or transcatheter tricuspid valve intervention
Authors: Lawlor Matthew K. , Hamid Nadira , Kampaktsis Polydoros , Ning Yuming , Wang Victoria , Akkoc Deniz , Dershowitz Lyle , Placheril Elizabeth , Vahl Torsten P. , Nazif Tamim , Khalique Omar , Ng Vivian , Brener Michael I. , Burkhoff Daniel , Dickstein Marc , Kurlansky Paul , Leon Martin B. , Hahn Rebecca T. , Kodali Susheel , George Isaac 
Published: January 2022

AbstractObjectiveThe objective of this study was to evaluate the incidence of and risk factors associated with cardiogenic shock (CS) following surgery versus transcatheter tricuspid valve intervention (TTVI) for tricuspid regurgitation (TR).BackgroundSurgical therapy for TR is associated with high rates of CS. Postprocedural shock has not been studied following TTVI.MethodsWe performed a single‐center retrospective analysis of isolated tricuspid valve (TV) surgery or TTVI for TR. The primary outcome was postprocedural class D or E CS according to Society for Cardiovascular Angiography and Interventions (SCAI) CS classification scheme, and secondary outcome was in‐hospital mortality. Multivariable logistic regression modeling was performed for primary and secondary outcomes. Support vector machine analysis was performed for sensitivity analysis.ResultsFrom 2008 to 2020, a total of 122 patients underwent isolated TV surgery (n = 58, 14 TV repair, and 44 TV replacement) or TTVI (n = 64, 36 TV repair, and 28 TV replacement). Surgical patients were significantly younger than TTVI patients (67.5 vs. 80 years, p < 0.0001). Multivariable modeling revealed an association between the primary outcome and surgery (odds ratio [OR]: 8.75, 95% confidence interval [CI]: 2.83, 27.03, p = 0.0002), as well as baseline central venous pressure (CVP, OR: 1.12, 95% CI: 1.02, 1.22, p = 0.016). Additionally, class DE CS was independently associated with in‐hospital mortality (OR: 5.21, 1.35, 20.09, p = 0.016). CVP and surgery were found to have highest importance indices in support vector machine analysis.ConclusionIn patients undergoing TV intervention for TR, surgery versus TTVI and elevated CVP are associated with advanced postprocedural CS. Patients developing advanced CS are at increased risk of in‐hospital mortality.
Percutaneous decannulation of extracorporeal membrane oxygenation using a plug‐based closure device
Authors: Dalén Magnus , Settergren Magnus , Kastengren Mikael , Ullström Pia , Fux Thomas 
Published: January 2022

AbstractBackgroundThere is limited experience of using the MANTA plug‐based vascular closure device for percutaneous arterial closure of the femoral artery after venoarterial extracorporeal membrane oxygenation.ObjectivesTo study femoral artery complications and need for subsequent vascular interventions after percutaneous decannulation of venoarterial extracorporeal membrane oxygenation (VA ECMO) using the MANTA plug‐based vascular closure device.MethodsWe studied 34 consecutive patients who underwent percutaneous decannulation of VA ECMO using the MANTA device. Primary outcomes were conversion to surgical cutdown of the groin at decannulation (immediate) or later. Secondary outcomes were type of vascular complication necessitating conversion to surgical cutdown of the groin.ResultsSix (17.7%) patients had to undergo immediate (n = 3) or late (n = 3) conversion to surgical cutdown of the groin. Of these, three were owing to occlusion of the common femoral artery resulting in insufficient distal perfusion and three owing to bleeding or pseudoaneurysm. The mechanism of failure was complete intravascular deployment of the MANTA device in three patients, incomplete MANTA sealing of the arteriotomy in one patient, MANTA‐unrelated thrombotic occlusion in one patient, and unknown in one patient. Surgical cut‐down was typically performed with concomitant catheter thrombectomy with or without patch reconstruction of the artery.ConclusionPercutaneous decannulation of VA ECMO using the MANTA VCD was feasible but a substantial number of patients needed to be converted to unplanned surgical repair, owing to either closure site‐located stenosis/occlusion or bleeding. If suboptimal MANTA positioning is suspected, a low threshold for conversion to surgical cutdown of the groin is recommended.