bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review on the Neuroprotective Effect of Berberine against Chemotherapy- induced Cognitive Impairment
Authors: Sahu Kuleshwar , Singh Sukhdev , Devi Bhawna , Singh Charan , Singh Arti 
Published: March 2022

Abstract:Chemobrain is one of the major side effects of chemotherapy; despite increased research, the mechanisms underlying chemotherapy-induced cognitive changes remain unknown. Several pos-sibly important candidate mechanisms have been identified and will be studied further in the future. Chemobrain is characterized by memory loss, cognitive impairment, difficulty in language, concen-tration, acceleration, and learning. The major characteristic of chemobrain is oxidative stress, mito-chondrial dysfunction, immune dysregulation, hormonal alteration, white matter abnormalities, and DNA damage. Berberine (BBR) is an isoquinoline alkaloid extracted from various berberine species. BBR is a small chemical that easily passes the blood-brain barrier (BBB), making it useful for treat-ing neurodegenerative diseases. Many studies on the pharmacology of BBR have been reported in the past. Furthermore, several clinical and experimental research indicates that BBR has a variety of pharmacological effects. So, in this review, we explore the pathogenesis of chemobrain and the neu-roprotective potential of BBR against chemobrain. We also introduced the therapeutic role of BBR in various neurodegenerative and neurological diseases such as Alzheimer's, Parkinson's disease, mental depression, schizophrenia, anxiety, and also some stroke.
Changing Characteristics of Patients Living with HIV/AIDS After the
COVID-19 Pandemic in Turkey
Authors: Karaosmanoglu Hayat Kumbasar , Mete Birgul , Gunduz Alper , Sevgi Dilek Yildiz , Aydin Ozlem Altuntas , Dokmetas Ilyas , Tabak Fehmi 
Published: March 2022

Aims:
The COVID-19 pandemic has substantially changed lives and presented several barriers
to health services. HIV care continuum needs a high rate of diagnosis, effective treatment, and
sustained suppression of viral replication. The COVID-19 pandemic has affected these three steps of
HIV care. This study investigated the characteristics of newly diagnosed patients living with
HIV/AIDS (PLWH) during the COVID pandemic and compared them with those before the pandemic.

Methods:
All newly diagnosed patients in three HIV healthcare centers, in Istanbul, Turkey, were
included in the study. The pandemic period included April 1, 2020, to April 1, 2021, and the prepandemic
period included March 1, 2019, to March 1, 2020.

Results:
756 patients were diagnosed with HIV/AIDS. In the pandemic period, this figure was 58%
less: 315. Patients in the pre-pandemic and pandemic period had comparable age and gender distributions.
PLWH diagnosed in the pandemic period had higher rates of low CD4 cells: low CD4 (<350
cells /mm3) was measured in 243 (36.4%) patients in the pre-pandemic period, while it was done in
126 (47.9%) in the pandemic period (p<0.01). Also, the distribution of CD4 cells was significantly different
between periods: In the pandemic period, CD4 cell distribution significantly skewed to lower
CD4 categories. Symptomatic patient rates and AIDS-defining disorder rates among symptomatic patients
were comparable. Viral loads were not significantly different in the two periods.

Conclusion:
A low number of newly diagnosed PLWH can be explained by less HIV testing, less
admission to health care, or an actual decrease of HIV prevalence during the pandemic. Sexual behaviors
may have changed during the COVID-19 pandemic, leading to HIV transmission restriction.
Lower CD4 counts among the newly diagnosed PLWH suggest that admittance to health care is late
and a significant portion of PLWH remain undiagnosed.
Pharmacological Significance of Synthetic Bioactive Thiazole Derivatives
Authors: Amin Andleeb , Qadir Tanzeela , Salhotra Alka , Sharma Praveen Kumar , Jeelani Ishtiaq , Abe Hitoshi 
Published: March 2022

Abstract:
Thiazole and the related nuclei constitute one of the most significant moieties in the
extensively emerging domain of heterocyclic compounds. The versatile nature of the thiazole nucleus
can be determined as it is present in natural products like vitamin B1. Furthermore, its derivatives
exhibit diverse biological activities, including antimicrobial, anticancer, antihistaminic, antioxidant,
etc. They have also emerged as potent CNS agents and are primarily used in the treatment
of various CNS disorders. The structure-activity relationship of various amine derivatives of ethylated
thiazole demonstrates their use as potential agents in the treatment of melanoma, pigmentation
as well as solar elastosis. Thiazole fused with different heterocyclic systems results in many novel
derivatives with higher therapeutic activity. Benzothiazole and Thiazolopyrimidine have a distinct
position in this regard. This review focuses on the central role of thiazole and its derivatives in
current drug design, covering a broad spectrum of pharmacological activities associated with them.
Growth Hormone/Insulin-like Growth Factor 1 Axis Associated with
Modifier Factors in Children with Sickle Cell Anemia
Authors: Costa-Júnior Domício Antônio da , Santos Ana Paula Pinho , da Silva Célia Maria , Velloso-Rodrigues Cibele 
Published: March 2022

Background:
Sickle cell anemia is a disease that develops episodes of acute pain and multiple organ dysfunction that can affect the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis. The severity of sickle cell anemia is influenced by modifying factors, such as levels of fetal hemoglobin (HbF), the co-inheritance of alpha-thalassemia, or treatment with hydroxyurea.

Methods:
This cross-sectional study in children with sickle cell anemia evaluated bone age (BA), adult height prediction (AHP) using BA, a target height (TH) calculated as the mean SDS of the parents, and laboratory parameters. Children were grouped according to serum levels of HbF, co-inheritance of alpha-thalassemia, and hydroxyurea therapy.

Results:
The mean age of the 39 children was 8.2 ± 2.2 years old. The average height was -0.75 ± 0.30 SDS, and 10.3% (4/39) had short stature. Adjusted levels of IGF-1 or IGFBP-3 were significantly higher in children with sickle cell anemia on hydroxyurea treatment, in children with HbF levels >10%, and in those without alpha-thalassemia. Using SDS, the growth potential of children with sickle cell anemia in relation to their parents calculated by the difference between AHP and TH as well as the difference between children’s height and their TH, were lower in children with co-inheritance of alpha-thalassemia.

Conclusion:
The study showed an association between modifying factors and the GH/IGF-1 axis in children with sickle cell anemia. Additionally, the co-inheritance of alpha-thalassemia was associated with decreased height in these children when adjusted for their parents’ height.
Sob as águas, respirar e resistir
Authors: Daré Paula Serafim 
Published: March 2022

Em uma troca de mensagens da equipe da Self, falávamos da necessidade de 2022 chegar de mansinho, depois de uma travessia difícil, que ainda não terminou, marcada pela pandemia da Covid-19 e agravada por um quadro de desemprego, inflação e desgoverno do país.
O ano de 2022, no entanto, chegou com enchentes na Bahia, Minas Gerais e Petrópolis, região serrana do Rio de Janeiro, com um novo surto de COVID-19 e da gripe influenza e a queda de uma gigantesca rocha em Capitólio (MG). No plano internacional, a Rússia entra em guerra contra a Ucrânia, revivendo lembranças difíceis da última grande guerra mundial.
Evidence for Continuing Professional Development and Recency of Practice Standards for Regulated Health Professionals in Australia: Protocol for a Systematic Review
Authors: Main Penelope , Anderson Sarah 
Published: March 2022

Background
Continuing professional development (CPD) and recency of practice (ROP) standards are components of health practitioner regulation in Australia. The CPD and ROP standards are currently under review, and an evidence base to assist the development of consistent standards is required. Preliminary searching was unable to find a recent systematic review of the literature to provide an evidence base to underpin the standards review.

Objective
This paper presents the protocol for a systematic review that aims to develop a current evidence base that will support the National Boards to develop more consistent, evidence-based, effective standards that are clear and easy to understand and operationalize.

Methods
Research questions were developed to support the planned review of CPD and ROP registration standards. Major databases and relevant journals were searched for articles published in English between 2015 and 2021, using key search terms based on previous unpublished reviews of the CPD and ROP registration standards. The quality of the articles retrieved will be assessed using an instrument suitable for use in the development of public policy. The findings will be published in a peer-reviewed journal.

Results
In September 2021, our search strategy identified 18,002 studies for the CPD-related research questions after removal of duplicates. Of these, 509 records were screened based on their title, and 66 full-text articles were assessed for eligibility based on their abstract, of which 31 met the inclusion criteria. A further 291 articles were identified as relevant to the ROP research questions. Of these, 87 records were screened based on their title, and 46 full-text articles were assessed for eligibility based on their abstract, of which 8 studies met our inclusion criteria.

Conclusions
This protocol outlines the scope and methodology that will be used to conduct a systematic review of evidence for CPD and ROP and inform a review of the standards for regulated health professionals in Australia. Previous research has shown that while CPD improves practitioner knowledge, the link to public safety is unclear. While there has been a greater focus on maintenance of certification and other quality assurance activities over the past 10 years, there remains great variability in CPD requirements across both professions and jurisdictions. ROP was found to be a poorly researched area with most research concentrating on medical practitioners, nurses, and midwives and no clear consensus about the optimal time period after which retraining or an assessment of competence should be introduced. As the CPD and ROP standards are currently under review, it is timely that a review of current evidence be undertaken.

International Registered Report Identifier (IRRID)
DERR1-10.2196/28625
INSURANCE DEVELOPMENT AND LIFE QUALITY IN THE EUROPEAN UNION COUNTRIES. AN EMPIRICAL ASSESSMENT
Authors: Cristea Mirela , Noja Graţiela Georgiana , Drăgoi Doina , Andriţoiu Leontina Codruţa 
Published: March 2022

The connection between insurance and economic development has been intensively addressed in the literature, but a comprehensive analysis including the dimensions of human capital/quality of life has been less considered. The general objective of this research is to assess the degree of development of the insurance sector in the interplay with the representative dimensions of quality of life, at the level of the European Union (EU) Member States (MS), and to propose strategies for narrowing the gap between countries. The data encloses representative indicators that reveal the size of the insurance market, on the one hand, and the dimensions of quality of life, on the other hand, at the level of 2019. The research methodology consists of cluster analysis with the Ward method. The main results reveal that, at the level of all EU-27 Member States, the size of the insurance market is interconnected with the quality of life, with significant differences between them, developing countries having modest results compared to developed countries. Thereby, specific strategies and policies for these groups of countries are paramount, in order to enhance the wellbeing by insurance services and coverage.
Reactivación partidaria. La campaña electoral de 1983 en la prensa chaqueña
Authors: Campusano Marina Noemí , De los Reyes Andrea 
Published: March 2022

Este artículo se propone reconstruir el proceso de reactivación que supuso la reconstrucción democrática para el Partido Justicialista y la Unión Cívica Radical, principales fuerzas políticas en la provincia del Chaco, a partir del análisis de la campaña electoral de 1983. En particular, trabajamos con los diarios El Territorio y Norte, considerando las oportunidades que el proceso electoral permitió evidenciar en la prensa local. Así, siguiendo el enfoque sociohistórico, abordamos la temática en dos ejes: qué dicen y qué hacen los actores políticos en este escenario, a partir de las páginas de los diarios y de entrevistas a militantes. De este modo, damos cuenta del universo militante compartido, las acciones al interior de los espacios y por fuera de ellos para organizar el trabajo militante y asegurar el reposicionamiento de los actores políticos en un momento complejo e incierto de la historia política local y nacional.
Planning and Implementation of the "Library of Dipanegara" at STMIK Library"
Authors: Syaiful S Muhammad , Muliyadi Irvan 
Published: March 2022

Kegiatan yang dilakukan di perpustakaan mulai dari penginputan, pendataan, hingga pelayanan ketika itu dilakukan secara manual tentu akan menimbulkan beberapa hambatan serta membutuhkan banyak waktu. Perpustakaan sebagai wadah yang dalam aktivitasnya menghimpun, mengatur, ataupun merawat bahan pustaka, harus didukung dengan penyajian informasi yang cepat dan akurat. Oleh karena itu perlu adanya sistem informasi di perpustakaan.Rancangan sistem informasi ini bertujuan untuk memudahkan pustakawan dan pemustaka dalam proses sirkulasi di perpustakaan. Dalam penelitian ini penulis menggunakan metode pengambilan data secara kualitatif. Sedangkan instrumen untuk pengumpulan data yang digunakan yaitu observasi, wawancara, dan studi literatur. Sistem ini memiliki beberapa fitur seperti penginputan buku, data buku, data anggota, peminjaman dan pengembalian buku. Sistem informasi ini dibuat menggunakan bahasa pemrograman PHP dan MySQL untuk basis datanya. Sistem ini mengggunakan metode pengujian Blackbox. Dari hasil penelitian ini menghasilkan sebuah sistem informasi yang dapat memudahkan pustakawan dalam pelayanan sirkulasi di perpustakaan.ABSTRACTActivities carried out in the library, starting from inputting, collecting data, to services when it is done manually, will certainly cause several obstacles and require a lot of time. Libraries as a media that in their activities to collect, to organize, or to maintain library materials, must be supported by the present of fast and accurate information. Therefore, it is necessary to have an information system in the library. This information system is aims to facilitate librarians in the circulation area. This system has several features such as book entry, book data, member data, book borrowing and return. This information system is created using the PHP programming language and MySQL for its database. This system uses the Blackbox testing method. The results of this study showed that an information system is needed so that can facilitate librarian in circulation services in the library.
Analisis Pemanfaatan Koleksi American Corner di Perpustakaan Unand
Authors: Islami Gema Putra 
Published: March 2022

Collection is a term that is used widely in the library world to describe what library materials should be held in the library. Types of library collections, printed collections, non-printed collections, graphic material collections, electronic collections. American Corner is one of the services in collaboration with the Unand library. There are 4 corner services at the Unand library, namely American Corner, Franch Corner, Minangkabau Corner and BI Corner. American Corner itself is a service under the American embassy in Indonesia which aims to introduce, attract and broaden Unand students' knowledge about all things about America. The method used is qualitative, namely in the form of direct interviews with related parties. After the data has been collected, the writer will analyze the results of the interview and make a way for how the use of this collection can be used by all Unand students. Koleksi adalah suatu istilah yang digunakan secara luas di dunia perpustakaan untuk menyatakan bahan perpustakaan apa saja yang harus diadakan di perpustakaan. Jenis koleksi perpustakaan, koleksi tercetak, koleksi non cetak, koleksi bahan grafika, koleksi dalam bentuk elektronik American Corner merupakan salah satu layanan yang bekerjasama dengan perpustakaan Unand. Layanan corner di perpustakaan Unand sendiri memiliki 4 yaitu American Corner, Franch Corner, Minangkabau Corner dan BI Corner. American Corner sendiri merupakan layanan di bawah lembaga kedutaan Amerika yang ada di Indonesia yang bertujuan memperkenalkan, serta menarik minat dan menambah wawasan mahasiswa Unand tentang segala hal tentang Amerika. Metode yang dipakai ialah kualitatif yaitu berupa wawancara langsung terhadap pihak yang terkait. Setelah data terkumpul maka penulis akan menganalisis hasil dari wawancara dan melakukan cara untuk bagaimana pemanfaatan koleksi ini dapat dimanfaatkan oleh seluruh mahasiswa Unand.
Analisis Desain Interior Perpustakaan di Dinas Perpustakaan dan Kearsipan Kota Padang Panjang
Authors: Yasmon Tania 
Published: March 2022

This article aims to find out and describe how the interior design of the Padang Panjang City library includes a public reading room. A storage room (specifically for reference collections) and children's reading room. The data from this study were obtained from direct observations in the field by the author. Data analysis used descriptive qualitative data analysis which begins with collecting data, analyzing the data, then presenting the data obtained and then making inferences on the results obtained. From the results of data collection, it can be concluded that the interior design of the Padang Panjang City library has followed the applicable standards which based on color selection, furniture, ergonomics, and lighting provide comfort and friendliness to visitors. Artikel ini bertujuan untuk mengetahui serta mendeskripsikan bagaimana desain interior di perpustakaan Kota Padang Panjang yang meliputi ruang baca umum. Ruang tandon (khusus koleksi referensi) dan ruang baca anak. Data dari penelitian ini didapat dari hasil pengamatan langsung ke lapangan oleh penulis. Analisis data yang digunakah analisis data kualitatif deskriptif yang diawali dengan mengumpulkan data, menganalisis data, lalu menyajikan data yang didapat dan kemudian melakukan penyimpulan terhadap hasil yang didapat. Dari hasil pengumpulan data didapat kesimpulan bahwa desain interior perpustakaan Kota Padang Panjang sudah mengikuti standar yang berlaku dimana berdasarkan pemilihan warna, perabotan, ergonomi, dan pencahayaan memberikan kenyamanan dan ramah terhadap pengunjung.
Hubungan Layanan Sirkulasi dengan Pembentukan Citra Perpustakaan (Studi Deskripsi di Perpustakaan Universitas Andalas)
Authors: Irfan Rifan Irfandi 
Published: March 2022

Circulation services, in English circulation is “circulation”, which is a round in the world of libraries, this service division serves as a lending service and a customer service. In the world of libraries, this service is very important, therefore the services in this section require library management personnel to be equipped with knowledge and skills in managing libraries, especially in the circulation services section. From this description, it can be concluded that circulation services are activities that must be in the library related to the borrowing and returning library materials so that they can be used optimally by users. This circulation service aims to make the use of collections effective and the control of collections in the library can be considered because they can know when the users borrow and return the collections borrowed from the library, therefore the collections can be performed well. If the user is late in returning the collection, he will be subject to a fine that has been agreed upon and determined by the library. Layanan sirkulasi, dalam bahasa inggris sirkulasi ialah “circulation” ialah putaran di dunia perpustakaan bagian layanan ini bertugas untuk sebagai pelayanan peminjaman dan pelayanan pemustaka. Di dalam dunia perpustakaan layanan ini sagatlah penting oleh karena itu layanan yang ada bagian ini Untuk itu membutuhkan tenaga pengelola perpustakaan perlu dibekali pengetahuan dan keterampilan mengelola perpustakaan khususnya pada bagian pelayanan sirkulasi. Dari uraian tersebut bisa disimpulkan bahwa pelayanan sirkulasi adalah kegiatan yang harus ada di dalam perpustakaan yang berhubungan dengan bagian peminjaman dan pengembalian bahan pustaka agar dapat dipergunakan oleh pengguna secara maksimal. Layanan sirkulasi ini bertujuan agar pemakaian koleksi bisa efektif dan pengawasan terhadap koleksi di perpustakaan bisa diperhatikan karena bisa tau kapan pemustaka meminjam dan mengembalikan koleksi yang di pinjam di perpustakaan oleh karena itu koleksi dapat terja denan baik. Jika pemustaka tersebut terlambat mengembalikan koleksi maka akan dikena denda yang telah disepakati dan ditetapkan oleh perpustakaan tersebut.
Ultrasonic wave promoting ice melt in ice storage tank based on polynomial fitting calculation model
Authors: Li Chengjun , Zhang Huan , Wang Tianyu , Zhang Jianming , Li Chengchun , Yu Dong 
Published: March 2022

Abstract
The existence of floating ice in ice storage tanks in an ice storage system affects the normal operation of the ice storage automatic control system. For the ice storage tank in an ice storage system, the ice “problem”, puts forward the way of melting ice in an ultrasonic assisted manner. This paper establishes a polynomial mathematical model of observation data changes over time, by setting a variable’s value used to model the polynomial fitting method. It could be used in the design and operation index model or higher polynomial model fitting process of melting ice. Ultrasonic wave is used to solve the floating ice problem of ice storage tank in the operation of ice storage, and the effects of ultrasonic power density, ice-water ratio, ice size, initial ice amount and other parameters on the characteristics of ice melting are tested and analysed through experiments, which provides an important reference for the practical application of this technology. It is found that the ultrasonic wave can obviously promote and strengthen the melting of ice, and the influence of power, ice–water ratio and ice size conforms to the normal theory and practice law. The greater the power, the smaller the ice–water ratio and the smaller the ice size, the faster the melting speed will be. Due to the multiple effects of technology and economy, the power density has an optimal value, which needs to be optimised according to the actual situation in the application. For large size ice, the promotion effect of high-power ultrasonic on melting ice is more obvious.
Pengelolaan Sumberdaya Arkeologi untuk Pariwisata Berkelanjutan (Pengembangan Wisata Benteng di Pulau Ambon)
Authors: Mansyur Syahruddin 
Published: March 2022

Pemerintah Pusat melalui Departemen Kebudayaan dan Pariwisata telah menetapkan tahun 2008 sebagai “Visit Indonesian Year”. Salah satu potensi wisata yang dapat dikembangkan untuk mendukung program ini adalah wisata arkeologi khususnya wisata benteng yang jumlahnya cukup banyak dan tersebar dihampir seluruh pulau di Maluku. Wisata benteng di Maluku yang saat ini masih mengandalkan benteng sebagai satu-satunya daya tarik menunjukkan belum optimalnya Pemerintah Daerah mengembangkan wisata ini. Salah satu upaya yang perlu dilakukan adalah dengan mengemas berbagai atraksi wisata sebagai tambahan daya tarik bagi wisatawan yang akan berkunjung. Makalah ini mencoba memaparkan prospek wisata benteng di Pulau Ambon dengan menawarkan langkah-langkah yang perlu dilakukan dalam upaya pengembangan wisata yang lebih optimal.