bluuebunny/crossref_metadata_2025_split huggingface dataset:
Litigating crashes? Insights from security class actions
Authors: Zhang Huilin , Ni Xiaoran , Jin Qi 
Published: September 2022

AbstractInvestors tend to litigate large stock price declines, i.e., file ‘stock‐drop lawsuits’. However, it is less clear whether the ex‐ante threat of security class actions can deter stock price crashes in the first place. To answer this question, we exploit the 1999 ruling of the Ninth Circuit Court of Appeals that discourages security class actions as a quasi‐exogenous shock, and find that reducing the threat of security class actions leads to a significant increase in stock price crash risk measured by negative skewness of stock returns. We reveal that the main effect is partially driven by a reduction in the timeliness of bad news disclosure and worsened earnings quality, which is consistent with the view that bad news hoarding serves as the key factor in the formation of a stock price crash. Our overall findings highlight the importance of security class actions in deterring the occurrence of firm‐level negative tail events on the financial market.
From Indenture to “Good Governance”: eMigrate and the Politics of Reforming Global Labour Supply Chains
Authors: Buckley Michelle , Chakravartty Paula , Gill Sahiba 
Published: September 2022

AbstractContract substitution—in which workers sign one contract but end up working under another—is a common form of fraud faced by Indian low‐wage migrant workers working in the Gulf Cooperation Council states. This paper presents a study of workers’ experiences of contract substitution alongside the eMigrate system, which is a digital registration system introduced by the Indian government in 2015. While a stated aim of eMigrate is to protect workers from contract fraud, these practices persist. We explore the colonial genealogies of eMigrate to show that not only has it adapted repertoires of worker protection inherited from the British Empire’s indenture system, but that eMigrate risks facilitating conditions of unfreedom under the mantle of worker protection, much as the British imperial state did during indenture. We contend that recognising how legacies of indentured labour regulation persist through eMigrate has implications for contemporary campaigns for migrant justice.
Postoperative tolvaptan use in left ventricular assist device patients: The TOLVAD randomized pilot study
Authors: Belkin Mark N. , Imamura Teruhiko , Rodgers Daniel , Kanelidis Anthony J. , Henry Michael P. , Fujino Takeo , Kagan Viktoriya , Meehan Karen , Okray Justin , Creighton Shana , LaBuhn Colleen , Song Tae , Ota Takeyoshi , Jeevanandam Valluvan , Nguyen Ann B. , Chung Ben B. , Smith Bryan A. , Kalantari Sara , Grinstein Jonathan , Sarswat Nitasha , Pinney Sean P. , Sayer Gabriel , Kim Gene , Uriel Nir 
Published: September 2022

AbstractPurposeTolvaptan, a selective vasopressin type‐2 antagonist, has been shown to increase serum sodium (Na) and urine output in hyponatremic left ventricular assist device (LVAD) patients in retrospective studies. In this prospective randomized pilot study, we aimed to assess the efficacy of tolvaptan in this population.MethodsWe conducted a prospective, randomized, non‐blinded pilot study of LVAD recipients with post‐operative hyponatremia (Na < 135 mEq/L) (NCT05408104). Eligible participants were randomized to receive tolvaptan 15 mg daily in addition to usual care versus usual care alone. The primary outcome was a change in Na level and estimated glomerular filtration rate (eGFR), from the first post‐operative day of hyponatremia (the day of randomization) to discharge.ResultsA total of 33 participants were enrolled, and 28 underwent randomization (median age 55 [IQR 50–62]), 21% women, 54% Black, 32% ischemic cardiomyopathy, median baseline Na 135 (IQR 134–138). Fifteen participants were randomized to tolvaptan (TLV) and 13 were randomized to usual care alone (No‐TLV). Mean change in Na from randomization to discharge in the TLV group was 2.7 mEq/L (95%CI 0.7–4.7, p = 0.013) and 1.8 (95%CI 0.5–4.0, p = 0.11) in the No‐TLV group, though baseline and final Na levels were similar between groups. The mean change in eGFR was 2.6 ml/min/1.73 m2 (95%CI 10.1–15.3, p = 0.59) in TLV versus 7.5 ml/min/1.73 m2 (95%CI 5.2–20.2, p = 0.15) in No‐TLV. TLV participants had significantly more urine output than No‐TLV patients during their first 24 h after randomization (3294 vs 2155 ml, p = 0.043).ConclusionTLV significantly increases urine output, with nominal improvement in Na level, in hyponatremic post‐operative LVAD patients without adversely impacting renal function.
Will auditors charge more for corporate philanthropy? Evidence from China
Authors: Huang Chenghao , Tang Jing 
Published: September 2022

AbstractThis study examines the relationship between corporate philanthropy (CP) and audit fees. Using corporate donation data from China, our investigation finds that CP is significantly positively associated with audit fees. Resource‐seeking purpose and the enhanced publicity effect may be plausible channels behind this relationship. We further find that the frequency and intensity of donations reinforce this positive association. Additional analysis reveals that the resource‐seeking effect exists in any type of enterprise, while the enhanced publicity effect only exists in non‐SOEs. Our main results remain robust to a battery of additional tests. Overall, our findings suggest that by increasing audit workload and prospective audit risk, CP could make auditors more conservative such that they charge a higher audit fee. This article emphasizes the dialectic institutional stakeholder perspective in understanding the economic consequences of CP. Both the theoretical contributions and practical implications of these findings are discussed.
Reciprocal relationships between personality traits and psychological well‐being
Authors: Joshanloo Mohsen 
Published: September 2022

AbstractThis study used an American sample collected over a period of approximately 2 decades (at 3 time points) to examine the temporal relationships between psychological well‐being and personality traits (i.e., neuroticism, extraversion, agreeableness, conscientiousness, and openness to experience). The random‐intercept cross‐lagged panel model was used to separate between‐person and within‐person sources of variation. Between‐person correlations were comparable to those of previous studies. New insights were gained at the within‐person level. There were reciprocal relationships between psychological well‐being and openness and extraversion, suggesting the joint development of plasticity‐related traits and well‐being over time. The relationships between psychological well‐being and conscientiousness and agreeableness were unidirectional, with psychological well‐being preceding these traits. Despite a strong between‐person association between neuroticism and psychological well‐being, the two were not related at the within‐person level.
Oncological validation and discriminative ability of pentafecta criteria after open radical cystectomy
Authors: von Deimling Markus , Rink Michael , Klemm Jakob , Koelker Mara , König Frederik , Gild Philipp , Khonsari Maryam , Ludwig Tim A. , Marks Phillip , Dahlem Roland , Fisch Margit , Vetterlein Malte W. 
Published: September 2022

ObjectivesTo validate the pentafecta criteria (PC) proposed by the PROMETRICS group for outcome reporting after radical cystectomy in an open radical cystectomy (ORC) cohort with long‐term follow‐up and to assess the discriminative ability of PC attainment for oncological endpoints.Patients and MethodsBetween January 2009 and December 2017, 420 patients underwent ORC with pelvic lymph node dissection and urinary diversion for non‐metastatic bladder cancer. The PC were defined as reported by the PROMETRICS group. The primary endpoint was PC attainment, and oncological outcomes comprised further endpoints. We used uni‐ and multivariable logistic regression analysis to assess predictors of PC attainment. The discriminative ability of PC for overall mortality (OM), cancer‐specific mortality (CSM) and other‐cause mortality (OCM) was compared using Kaplan–Meier curves and cumulative incidence functions. After stratification by the number of PC attained, the association between PC attainment and the survival endpoints was tested on multivariable Cox regression and competing‐risks models.ResultsA total of 108 patients (26%) fulfilled all PC, while 195 (46%), 77 (18%), 35 (8.3%) and five (1.2%) attained 4/5, 3/5, 2/5 and ≤1/5 PC, respectively. Increasing age‐adjusted Charlson comorbidity index (odds ratio [OR] 0.80, P = 0.015) and incontinent diversion (OR 0.38, P = 0.005) were independent predictors of PC non‐attainment. The median follow‐up was 73 months. PC attainment (≥4/5 vs 3/5 vs ≤2/5 PC attained) was used to stratify patients into groups at significantly different risk of death (P < 0.001). A decreasing number of PC attained (<4/5) was associated with unfavourable survival estimates for both OM and CSM (all P ≤ 0.005) but not for OCM (all P ≥ 0.2).ConclusionsThe PC proposed by the PROMETRICS group represent accurate quality indicators for oncological outcome reporting after ORC for non‐metastatic bladder cancer and have a distinct discriminative ability to predict long‐term OM and CSM.
Oncogenic lesions and molecular subtypes in adults with B‐cell acute lymphoblastic leukemia
Authors: Yasuda Takahiko , Sanada Masashi , Tsuzuki Shinobu , Hayakawa Fumihiko 
Published: September 2022

AbstractB‐cell acute lymphoblastic leukemia (B‐ALL), a genetically heterogeneous disease, is classified into different molecular subtypes that are defined by recurrent gene rearrangements, gross chromosomal abnormalities, or specific gene mutations. Cells with these genetic alterations acquire a leukemia‐initiating ability and show unique expression profiles. The distribution of B‐ALL molecular subtypes is greatly dependent on age, which also affects treatment responsiveness and long‐term survival, partly accounting for the inferior outcome in adolescents and young adults (AYA) and (older) adults with B‐ALL. Recent advances in sequencing technology, especially RNA sequencing and the application of these technologies in large B‐ALL cohorts have uncovered B‐ALL molecular subtypes prevalent in AYA and adults. These new insights supply more precise estimations of prognoses and targeted therapies informed by sequencing results, as well as a deeper understanding of the genetic basis of AYA/adult B‐ALL. This article provides an account of these technological advances and an overview of the recent major findings of B‐ALL molecular subtypes in adults.
Effects of social distancing policy on labor market outcomes
Authors: Gupta Sumedha , Montenovo Laura , Nguyen Thuy , Lozano‐Rojas Felipe , Schmutte Ian , Simon Kosali , Weinberg Bruce A. , Wing Coady 
Published: September 2022

AbstractUS workers receive unemployment benefits if they lose their job, but not for reduced working hours. In alignment with the benefits incentives, we find that the labor market responded to COVID‐19 and related closure‐policies mostly on the extensive (12 pp outright job loss) margin. Exploiting timing variation in state closure‐policies, difference‐in‐differences (DiD) estimates show, between March 12 and April 12, 2020, employment rate fell by 1.7 pp for every 10 extra days of state stay‐at‐home orders (SAH), with little effect on hours worked/earnings among those employed. Forty percentage of the unemployment was due to a nationwide shock, rest due to social‐distancing policies, particularly among “non‐essential” workers.
The capillary lobule variant of radiation‐associated angiosarcoma in the setting of breast cancer: A diagnostic pitfall
Authors: Agrawal Shruti , Fritchie Karen J. , Fernandez Anthony P. , Ko Jennifer S. , Bergfeld Wilma , Rubin Brian P. , Billings Steven D. 
Published: September 2022

AbstractAimPost‐radiation angiosarcoma is an iatrogenic event seen in the setting of breast cancer treatment. Histopathologically, there are morphologic variants of angiosarcoma that mimic benign entities, including the capillary lobule variant of post‐radiation angiosarcoma. We present the largest case series to date of this histopathologic variant of post‐radiation angiosarcoma.Methods and ResultsCases of the capillary lobule variant of post‐radiation angiosarcoma from institutional/consultation archives from 2008 to June 2022 were reviewed. For inclusion, tumors had to occur in irradiated skin and exhibit a multi‐lobular proliferation of tightly packed capillary‐like vessels, as previously described in this variant. Prior ancillary studies were also reviewed. Eight cases met the criteria. All occurred in women treated with radiation for breast cancer (median age 75 years). All cases had similar findings, including a multi‐lobular proliferation of tightly packed vessels, infiltrative cords, and atypical single endothelial cells. A conventional angiosarcoma pattern was also seen in five cases. All cases tested were positive for vascular markers (CD31, CD34, and/or ERG) and MYC. MYC amplification was shown by FISH in all cases tested. Smooth muscle actin (SMA) was positive in pericytes in the capillary lobules in all five cases tested and areas of conventional angiosarcoma in two of three cases.ConclusionsThe capillary lobule variant of angiosarcoma is a rare and therefore potentially under‐recognized variant of post‐radiation angiosarcoma. The lobular architecture and SMA positivity may mimic benign vascular proliferations. Careful attention to histopathologic features and ancillary tests may facilitate accurate diagnosis.
How great tits respond to urgency‐based information in allopatric Southern house wren mobbing calls
Authors: Dutour Mylène , Fernández Gustavo J. , Randler Christoph 
Published: September 2022

AbstractMany species of birds use alarm calls to signal information about predators, including the level of threat. Previous playback experiments suggest that the urgency response towards heterospecific calls is phylogenetically conserved, notably in the Paridae family. Using playback experiments conducted on European great tits (Parus major), we tested whether this species perceives information about urgency in mobbing calls produced by an allopatric non‐Paridae species, the Southern house wren (Troglodytes aedon bonariae), by broadcasting calls with high‐calling rate (high threat) and calls with low‐calling rate (low threat). We found that great tits tend to approach the loudspeaker during playbacks of calls with high‐calling rate more often than during playbacks of calls with low‐calling rate. Female great tits gave more calls during playbacks of calls with high‐calling rate than during playbacks of calls with low‐calling rate, whereas there was no significant difference in the number of calls given by males between playbacks of calls with high‐ and low‐calling rates. Thus, our results suggested that great tits perceived the urgency message encoded in calls given by an allopatric non‐Paridae species.
Effectiveness of root canal treatment for vital pulps compared with necrotic pulps in the presence or absence of signs of periradicular pathosis: A systematic review and meta‐analysis
Authors: Rossi‐Fedele Giampiero , Ng Yuan‐Ling 
Published: September 2022

AbstractBackgroundPreoperative pulpal status may influence the outcomes of root canal treatment (RCTx) according to various measures used.ObjectivesTo compare the effectiveness of RCTx of teeth with a vital pulp versus a necrotic pulp, using a range of clinical and patient‐related outcomes proposed for the development of S3‐level clinical practice guidelines.MethodsA search was conducted in the PubMed‐MEDLINE, Scopus, EMBASE, Google scholar databases and available repositories, followed by hand searches, until 29 March 2022. Clinical studies published in the English language comparing the stipulated outcomes of RCTx of teeth with vital versus necrotic pulp were included. The Newcastle–Ottawa Scale was adapted to assess study quality. Effects of pulpal status were estimated and expressed as risk ratio (RR) using fixed‐ and random‐effect meta‐analyses. The quality of evidence was assessed through the Grading of Recommendations Assessment, Development and Evaluation tool.ResultsTwenty‐eight studies published between 1961 and 2021 were included. Five studies have investigated the “tooth survival” outcome, four reported pulpal status was not a significant predictor, consistent with meta‐analysis findings (RR: 1.00; 95% CI: 1.00, 1.00; n = 3). Seven studies reported pulpal status had no significant influence on postoperative pain, regardless of duration after treatment. Sixteen studies have analysed “periapical health,” and 11 revealed pulpal status had no significant influence. Meta‐analyses revealed the influence was not significant if preoperative periapical radiolucency was absent (RR: 0.95; 95% CI: 0.90, 1.00; n = 9) but significant if it was present (RR: 1.12; 95% CI: 1.05, 1.19; n = 11). Most studies were classified as “some concerns” (n = 17) to “low” (n = 9) risk of bias RoB.DiscussionEvidence is limited and only available for three outcomes when comparing the effectiveness of RCTx in permanent teeth with vital pulp versus pulp necrosis. Nevertheless, the quality of available evidence was moderate to high. The “periapical health” data heterogeneity could be explained by preoperative radiolucency, thus RCTx was found more effective for prevention than the resolution of apical periodontitis.ConclusionsThere was no significant difference in the “tooth survival,” “postoperative pain” and “evidence of apical radiolucency” outcomes of RCTx in teeth with vital or necrotic pulps.RegistrationPROSPERO database (CRD42021260280).
Exploring masstige brands' antecedents and outcomes
Authors: Rodrigues Paula , Sousa Ana , Fetscherin Marc , Borges Ana Pinto 
Published: September 2022

AbstractThis study focused on developing a new conceptual model of consumers' perceptions of—and behaviours towards—masstige brands based on consumer‐brand relationship and brand equity theory, which was then applied using quantitative data analysis. The research model facilitated an exploration of how important brand love, co‐creation and need for uniqueness are as masstige brand antecedents and of whether brand happiness, brand loyalty and electronic word of mouth are outcomes. The proposed model's generalisability was assessed based on consumer data on a total sample of 1041 consumers from three countries: the United States, Portugal and China. The hypotheses were tested using partial least squares‐structural equation modelling. The results show that the model is well specified, and all the hypothesised relationships between the selected constructs related to masstige brands are supported by the data. The five brands included in the questionnaire have Masstige Mean Score Scale Index values indicating that these brands fit in this classification. The findings have a wide range of theoretical and managerial implications.
Surface modification of peanut meal with atmospheric cold plasma: Identifying the critical factors that affect functionality
Authors: Ji Hui , Tang Xiaojuan , Li Ling , Peng Shanli , Yu Jiao‐jiao 
Published: September 2022

SummaryPeanut meal (PM), a by‐product of processing, is hard to recycle due to its poor functional properties affected by the processing environment. To increase its utilisation value, atmospheric cold plasma (ACP) technology was used to enhance the functional properties of PM. Results showed that the soluble protein concentration, water holding capacity, surface hydrophobicity, foaming and emulsifying properties of PM were significantly improved after ACP treatment. The changes in amino acid composition, surface element content, apparent conformation, Fourier transform infrared spectroscopy and secondary structure of the protein in PM indicated that ACP treatment promoted the interaction between components of PM by introducing oxygen‐containing groups and producing etching. The protein molecule tended to be flexible, so as to improve the overall function of PM. ACP could be an effective and promising method to improve the functional properties of agricultural by‐products for further utilisation.
Metabolic plasticity and regulation of T cell exhaustion
Authors: Li Fei , Liu Huiling , Zhang Dan , Ma Yanlin , Zhu Bingdong 
Published: September 2022

AbstractThe metabolic reprogramming during T cell activation and differentiation affects T cell fate and immune responses. Cell metabolism may serve as the driving force that induces epigenetic modifications, contributing to regulating T cell differentiation. Persistent pathogen infection leads to T cell exhaustion, which is composed of two main subsets and with distinct metabolic characteristics. The progenitor exhausted T cells utilize mitochondrial fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) for energy, while terminally exhausted T cells mainly rely on glycolytic metabolism with impaired glycolysis and OXPHOS. Here, we compiled the latest research on how T cell metabolism defines differentiation, focusing on T cell exhaustion during chronic infections. In addition, metabolic‐related factors including antigen stimulation signals strength, cytokines and epigenetics affecting T cell exhaustion were also reviewed. Furthermore, the intervention strategies on metabolism and epigenetics to reverse T cell exhaustion were discussed in detail, which may contribute to achieving the goal of prevention and treatment of T cell exhaustion.
Transcriptomic profiling of cardiac tissues from SARS‐CoV‐2 patients identifies DNA damage
Authors: Kulasinghe Arutha , Liu Ning , Tan Chin Wee , Monkman James , Sinclair Jane E. , Bhuva Dharmesh D. , Godbolt David , Pan Liuliu , Nam Andy , Sadeghirad Habib , Sato Kei , Bassi Gianluigi Li , O'Byrne Ken , Hartmann Camila , dos Santos Miggiolaro Anna Flavia Ribeiro , Marques Gustavo Lenci , Moura Lidia Zytynski , Richard Derek , Adams Mark , de Noronha Lucia , Baena Cristina Pellegrino , Suen Jacky Y. , Arora Rakesh , Belz Gabrielle T. , Short Kirsty R. , Davis Melissa J. , Guimaraes Fernando Souza‐Fonseca , Fraser John F. 
Published: September 2022

AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is known to present with pulmonary and extra‐pulmonary organ complications. In comparison with the 2009 pandemic (pH1N1), SARS‐CoV‐2 infection is likely to lead to more severe disease, with multi‐organ effects, including cardiovascular disease. SARS‐CoV‐2 has been associated with acute and long‐term cardiovascular disease, but the molecular changes that govern this remain unknown. In this study, we investigated the host transcriptome landscape of cardiac tissues collected at rapid autopsy from seven SARS‐CoV‐2, two pH1N1, and six control patients using targeted spatial transcriptomics approaches. Although SARS‐CoV‐2 was not detected in cardiac tissue, host transcriptomics showed upregulation of genes associated with DNA damage and repair, heat shock, and M1‐like macrophage infiltration in the cardiac tissues of COVID‐19 patients. The DNA damage present in the SARS‐CoV‐2 patient samples, were further confirmed by γ‐H2Ax immunohistochemistry. In comparison, pH1N1 showed upregulation of interferon‐stimulated genes, in particular interferon and complement pathways, when compared with COVID‐19 patients. These data demonstrate the emergence of distinct transcriptomic profiles in cardiac tissues of SARS‐CoV‐2 and pH1N1 influenza infection supporting the need for a greater understanding of the effects on extra‐pulmonary organs, including the cardiovascular system of COVID‐19 patients, to delineate the immunopathobiology of SARS‐CoV‐2 infection, and long term impact on health.