bluuebunny/crossref_metadata_2025_split huggingface dataset:
S100 proteins in head and neck squamous cell carcinoma
Authors: Hu Yihong , Han Yucheng , He Minhui , Zhang Yanqun , Zou Xianqiong 
Published: November 2022

Abstract
The most common tumor affecting the head and neck is head and neck squamous cell carcinoma (HNSCC). Characteristics of HNSCC include rapid onset, a lack of early diagnosis, drug resistance, relapse and systemic adverse effects, leading to inadequate prevention, diagnosis and treatment. Notably, previous research suggests that there is an association between S100 proteins and HNSCC. S100A8, S100A9 and S100A14 interfere with tumor cell proliferation by blocking the cell cycle. S100A4 enhances cancer stem cell properties, and interacts with actin and tropomyosin to promote tumor cell migration. S100A1, S100A8, S100A9, S100A10, S100A14 and S100P are involved in the occurrence and development of HNSCC via Hippo, nuclear factor κB, phosphatidylinositol kinase/protein kinase B/mammalian target of rapamycin and other signaling pathways. In addition, certain long non-coding RNAs (lncRNAs) and microRNAs are involved in regulating the expression of S100 proteins in HNSCC. Reducing the expression of certain members of the S100 protein family may improve the chemosensitivity of HNSCC. Collectively, these results suggested that S100 proteins may act as markers and targets for the prevention, diagnosis and treatment of HNSCC.
Performance of monocyte distribution width in predicting the need for respiratory support in COVID-19 patients
Authors: Daorattanachai Kiattichai , Hirunrut Chachchom , Pirompanich Pattarin , Weschawalit Sinee , Srivilait Winchana 
Published: November 2022

Abstract

Background:The emergence of the novel coronavirus caused by SARS-CoV-2 infection resulted in a global pandemic whose clinical features ranged from asymptomatic infection to a severe fulminant respiratory distress and death. The monocyte distribution width (MDW) is a novel inflammatory biomarker that reflects morphological changes in response to inflammation and has been shown to useful in identifying COVID-19 identification and predicting death. There are limited data on the use of MDW for predicting the need for respiratory support.The aim of the study was to determinethe performance of MDW in predicting the need for respiratory support in patients with SAR-CoV-2 infection.Methods:Our retrospective cohort study was conducted at Thammasat University hospital, Thailand. Hospitalized COVID-19 adult patients were enrolled. Respiratory support was any one of oxygen therapy, high flow nasal cannula, non-invasive or invasive mechanical ventilation. The performance of MDW was measured using the area under the receiver operating characteristic (AuROC) curve and multivariable logistic regression analysis evaluated the independent effect of MDW on respiratory support.Results:Of the 250 enrolled patients, 122 (48.8%) patients were received respiratory support. The mean MDW was significantly higher in respiratory support group: 27.2±4.6 vs 23.6±4.1 (p<0.001). An MDW≥25 alone had the best AuROC characteristics: 0.70 [95% confidence interval (CI); 0.65-0.76] for a sensitivity, specificity, and positive likelihood ratio of 71.9%, 68.2%, and 2.26, respectively. Combining age, respiratory rate and oxygen saturation increased the AUROC to 0.84 (95% CI; 0.79-0.88). Increasing age [adjusted odds ratio (aOR) 1.03], respiratory rate (aOR 1.11) and MDW≥25 (aOR 3.42) significantly increased the odds of needing respiratory support whilst a higher oxygen saturation significantly reduced it (aOR 0.81).Conclusion:MDW is a promising biomarker for predicting the need of respiratory support in COVID-19 patients and can easily be implemented in routine clinical practice.
Symptomatic vasospasm after resection of an intracranial epidermoid cyst: A case report
Authors: Higashino Masashi , Koyama Junji , Fujita Kenji , Akutsu Nobuyuki , Kawamura Atsufumi 
Published: November 2022

Abstract
We report a 10-year-old girl who developed symptomatic vasospasm after complete resection of a left cerebellopontine angle epidermoid cyst. Conservative management with intravenous hydration and administration of a corticosteroid and free radical scavenger was effective in resolving her symptoms and radiologic vasospasm. This rare complication should be considered even after an uneventful operation.
DarkFight: A detection method of violent behavior in dark place for intelligent monitoring system
Authors: Wang Jun , Xu Xiaolong 
Published: November 2022

Abstract
With the continuous development of deep learning, the use of deep learning methods for intelligent violent behavior recognition has become an active research field in computer vision. However, there are relatively few studies on violent behavior recognition in dark light environment. In this paper, we propose the DarkFight network model for violent behavior recognition in dark light environment. In the proposed DarkFight model, Resnet50 is used as the basic network model to extract features. In order to obtain multi-scale spatiotemporal features, DarkFight adds a multi-scale attention module PSA to the network. The DarkFight model uses Zero-DCE for low-light image enhancement. In order not to lose the spatiotemporal characteristics of the low-light environment, DarkFight uses the initial dark-light data and the enhanced data as the input to the two paths of the model. In addition, this paper researches the replacement of the traditional temporal global average pooling layer of the network with the BERT module to better utilize the temporal information when fusing the two path features. We construct a violent behavior dataset VDID (Violence Detection in Dark) in a dark-light environment, and conduct experimental verification on this dataset. The verification results show that the recognition precision of the DarkFight model increases by 2.51%, the accuracy increases by 3.4%, and the F1-score improves by 0.032.
A Novel Approach to Detect and Prevent Data Leakage in IoT using Blockchain Technology
Authors: M NAVANEETHAN , S JANAKIRAMAN 
Published: November 2022

Abstract
The Internet of Things is the next step in the evolution of communication and business(IoT). Real-world objects can create, receive, and exchange data in a seamless manner thanks to the Internet of Things. Several Internet of Things apps aims to automate processes and enable inanimate physical devices to work without human involvement. Existing and future IoT systems offer a lot of potential in terms of improving user comfort, efficiency, and automation. To integrate such a world in an ever-increasing way, high levels of security, privacy, authentication, and attack recovery are required. In this paper, the IoT data and logs are processed with a special Keyword Based Detection System (KBDS) based on the known data & log pattern and stored data attributes, and detect whether the data is shareable or not to the external world based on the sensitivity. Every data flow is noted and managed by the user in the User-Console. If the data is not shareable it will Alert-To-User (ATU). Then the data is getting stored in the InterPlanetary File System (IPFS), the IPFS hash related to the data & logs will be stored in Blockchain. Using Smart contract the user can decide to share which data to respective third-party.
Characteristic of CuMn Alloy Films Prepared by Using Electrochemical Deposition
Authors: Lee Wen-Hsi , Puteri Narendra Gharini , Chang C. W. 
Published: November 2022

Abstract
Copper-manganese (Cu-Mn) alloys are usually used in resistance materials with a low resistance and low temperature coefficient of resistance (TCR). However, current research and development has been mainly focused on thin film materials deposited by the sputtering method, which is also by the cost due to its vacuum equipment. In the study, three kinds of electrochemical deposition methods were used to prepare a Cu-Mn-Cu switch structure. Firstly, we prepared the Al thick film as the sacrificial layer by screen printing on the Al2O3 substrate, and then transformed the Al thick film into the Cu thick film by the chemical oxidation-reduction replacement reaction at 80°C for 75 minutes. Secondly, the electroplating method was used to deposit Mn on the as-replaced Cu film. Based on the results of the SEM and XRD, it could be seen that a high quality and desired Cu-Mn 9:1 ratio could be obtained by depositing at 1.6V for 10 minutes. Finally, the top Cu layer was coated on the surface again by electroless plating to complete the sandwich structure of the Cu-Mn-Cu. Sequentially, annealing under normal pressure in reducing the atmosphere was done to make the Cu and Mn interdiffusion into the alloy phase. Both the XPS and Raman confirmed that annealing in a nitrogen-hydrogen atmosphere could extremely reduce the possibility of manganese oxidation and showed promising electrical properties such as a low temperature coefficient of resistance at 900℃ (150 ppm).
Response of “Lollo Bionda” lettuce to drip and porous pipe irrigation
Authors: Kunze Alexander , Spreer Wolfram , Beck Michael , Kell Karin , Max Johannes F. J. 
Published: November 2022

Abstract
Under the impression of changing rainfall patterns, agriculture in Germany faces increasing drought stress problems and water saving irrigation is gaining importance in the agricultural practice. Porous pipes for subsurface irrigation are an innovative method which is promoted as a water-efficient way to apply irrigation water. In the present study “Ecotubes” porous pipe irrigation was used for irrigation of “Lollo Bionda” lettuce at the University of Weihenstephan-Triesdorf in Southern Germany and compared to state-of-the art drip irrigation both at surface and sub-surface installation. Four treatments were compared during three experimental cycles “summer”, “late summer” and “autumn”: (a) drip irrigation in standard surface installation (control), (b) sub-surface drip irrigation, (c) porous pipes at standard operation and (d) porous pipes at very low pressure. The treatments were compared in terms of crop development, irrigation water applied, yield and water use efficiency (WUE). The highest yields were observed at low pressure irrigation with porous pipes (39.4 t/ha) followed by subsurface drip irrigation (36 t/ha). However, it was shown that the total amount of irrigation water applied, rather than the irrigation method determined the overall yield level. Subsurface irrigation methods had the highest WUE with 50.5 and 49.6 kg/m3 for porous pipes and subsurface drip irrigation, respectively. The study shows that subsurface micro irrigation systems are good for water saving horticultural production in Germany. The use of porous pipes is a good option for subsurface irrigation depending on the technological development in terms of installation and recovery, and the durability of the material.
Temperature effect on electrochemical properties of lithium manganese phosphate with carbon coating and decorating with MWCNT for lithium-ion battery
Authors: Robles J. Herrera , Montes H. Camacho , Casillas P. E. García , Velasco-Santos C. , Martínez-Hernández A. L. , Herrera O. Raymond , Aquino J. A. Matutes , Coba L. Fuentes , Contreras L. Alvarez , Bordia R. K. 
Published: November 2022

Abstract
The ever-increasing demands for higher energy density and higher power capacity of Li-ion secondary batteries have led to a search for electrode materials whose capacities and performance are better than those available today. One candidate is lithium manganese phosphate, and it is necessary to understand its transport properties. These properties are crucial for designing high-power Li-ion batteries. In order to analyze the effect on the electronic conductivity with a conductor material, carbon nanotubes multi-walled, and glucose were used as a carbon source. Here the transport properties of LiMnPO4, LiMnPO4/C, and LiMnPO4/MWCNT are investigated using impedance spectroscopy. The electronic conductivity is found to increase with increasing the temperature from 2.92 x 10− 5 S cm− 1 to 6.11 x 10− 5 S cm− 1. The magnetization curves are investigated, and antiferromagnetic behavior below 34K is reported for the three compositions. The structural characterizations were explored to confirm the phase formation of material with XRD, TEM, and SEM
Short term effects of sodium-glucose cotransporter 2 inhibitors on lipid regulation in coronary artery disease patients undergoing Percutaneous Coronary Intervention: A Propensity-Matched Analysis
Authors: Lin Maoning , Shan Yu , Hu Xiaolong , Zhou Hui , Chen Zhezhe , Li Duanbin , Gao Menghan , Yang Siwei , Zhang Wenbin , Wang Min 
Published: November 2022

Abstract
Background
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are currently widely used hypoglycemic drugs. Due to its cardiorenal protective effect independent of hypoglycemic effect, it is turning out to be progressively significant in the cardiovascular field. However, the effect of SGLT2 inhibitors on lipids is still controversial. We aimed to investigate whether the use of SGLT2 inhibitors could further down-regulate LDL-cholesterol (LDL-C) level of patients undergoing percutaneous coronary intervention (PCI) with background hypolipidemic therapy.
Methods
The longitudinal data were collected from Hospital Information System (HIS) of the Sir Run Run Shaw Hospital. SGLT2 inhibitor users and nonusers undergoing PCI were selected. Lipid data at baseline and 1-month follow-up after PCI were recorded. Propensity score 1:1 matching (PSM), inverse probability of treatment weighting (IPTW), and overlap weighting (OW) were performed to adjust baseline demographic and clinical characteristics.
Results
We identified 2451 coronary artery disease patients undergoing percutaneous coronary intervention. On the one month follow up after PCI, the serum lipid profile of all patients showed that triglyceride (TG) (1.26 [0.94;1.75] vs 1.47 [1.06;2.06], P < 0.001), total cholesterol (TC) (3.32 [2.83;3.90] vs 4.20 [3.51;5.13], P < 0.001), LDL-cholesterol (LDL-C) (1.69 [1.27;2.13] vs 2.43 [1.81;3.12], P < 0.001), and VLDL-cholesterol (VLDL-C) (0.34 [0.14;0.57] vs 0.46 [0.22;0.74], P < 0.001) decreased significantly; Free fatty acids (FFA) (0.48 [0.33;0.61] vs 0.45 [0.28;0.56], P < 0.001) increased; HDL-cholesterol (HDL-C) and lipoprotein(a) (Lpa) have no significant difference (P > 0.05). There was no significant difference in the changes of seven indexes of serum lipid profile in PSM cohort, including 361 SGLT2 inhibitor users and 361 nonusers (P > 0.05). Similar trends were observed in IPTW and OW cohorts (P > 0.05).
Conclusions
In coronary artery disease patients undergoing percutaneous coronary intervention, SGLT2 inhibitors do not confer benefit or harm on lipid regulation in the context of the original hypolipidemic strategy.
Urolithin B attenuates cerebral ischemia-reperfusion injury by modulating Nrf2-regulated anti-oxidation in rats
Authors: Li lizhiwei , Tang Hua , Chen Xin-xin , Li Xuan-xuan , Chen Mao-hua , Ba Hua-jun , Lin Qun , Dai Jun-xia , Cai Jian-yong , Lu Chuan , Chen Xian-dong , Sun Jun , Han Guo-sheng 
Published: November 2022

AbstractIschemia-reperfusion (IR) causes a wide range of irreversible injuries. Cerebral IR injury (IRI) refers to further brain tissue damage after regaining blood flow following cerebral ischemia. Methods to treat IRI are still far from being established. Oxidative stress is one of the main mechanisms of IRI initializing, and considered as an essential entry point of the treatment of IRI. Urolithin B (UB, 3-Hydroxy-6H-dibenzo[b,d]pyran-6-one) is a metabolite of ellagitannins, which are antioxidant polyphenols and has been found to be protective against oxidative stress in a variety of diseases. It is unclear how UB affects cerebral IRI, however. In our present study, using a neurological deficit score, we found that UB could suppress IR-induced neurological functional damage. 2,3,5-triphenyltetrazolium chloride (TTC) staining and neuron nissl staining showed that cerebral infarction was improved after administration of UB. Terminal deoxynucleotidyl transferase-mediated dNTP nick end labeling (TUNEL) assay and Caspase-3 measurement indicated that UB inhibited neuronal apoptosis. The oxidative stress level, reduced by UB, was analyzed by malondialdehyde (MDA) concentration and the activity of superoxide dismutase (SOD), and immunohistochemistry of inducible nitric oxide synthase (iNOS) and 8-hydroxyl-2’-deoxyguanosine (8-OHdG). Mechanically, UB stimulated Nrf2/HO-1signaling pathway. The injection of ATRA, an Nrf2 inhibitor, significantly reduced UB's neuroprotective effects mentioned above. To sum up, UB inhibits oxidative stress caused by IR through activating the Nrf2/HO-1 signaling pathway, and could potentially be used for the treatment of IRI.
Dating Greek Papyri Images with Machine Learning
Authors: Paparrigopoulou Asimina , Pavlopoulos John , Konstantinidou Maria 
Published: November 2022

Abstract
Dating papyri accurately is crucial not only to editing their texts, but also for our understanding of palaeography and the history of writing, ancient scholarship, material culture, networks in antiquity, etc. Most ancient manuscripts offer little evidence regarding the time of their production, forcing papyrologists to date them on palaeographical grounds, a method often criticized for its subjectivity. By experimenting with data obtained from the Collaborative Database of Dateable Greek Bookhands and the PapPal online collections of objectively dated Greek papyri, this study shows that deep learning dating models, pre-trained on generic images, can achieve accurate chronological estimates for a test subset (67.97% accuracy for bookhands and 55.25% for documents). To compare the estimates of these models with those of humans, experts were asked to complete a questionnaire with samples of literary and documentary hands that had to be sorted chronologically by century. The same samples were dated by the models in question. The results are presented and analysed.
Evaluation of the growth rates and related prognostic factors in radiation-induced meningiomas
Authors: Entenmann Christian Joachim , Bubeníková Adéla , Blažko Jana , Zápotocký Michal , Kruseová Jarmila , Sumerauer David , Trková Kateřina , Sochová Vladimíra , Koblížek Miroslav , Kynčl Martin , Malinová Běla , Bradáč Ondřej ,   Vladimír Beneš 3rd
Published: November 2022

Abstract

Purpose
Literature dedicated to growth patterns and growth rate influencing factors of radiation-induced meningiomas (RIMs) is limited. To deliver new insights into the topic, a volumetric growth analysis of RIMs was performed.
Methods
This single-center, retrospective cohort study included patients diagnosed with intracranial meningioma who received radiation treatment at least > 5 years before the RIM diagnosis. Volumetric analysis of individual RIMs was performed using 3D volumetry at the time of RIM diagnosis and during follow-up. RIM growth was determined by calculating absolute (AGR), and relative (RGR) growth rates. Prognostic factors associated with RIM growth were evaluated.
Results
A total of 26 patients with 33 meningiomas were enrolled in the study and radiologically/clinically followed up during a median duration of 5.6 years (IQR, 3.9–8.8 years). Median AGR was 0.19 cm3 per year and the median RGR was 34.5% per year. Surgically managed RIMs were more likely fast-growing compared to observed ones based on the AGR (p < 0.002). The recurrence rate after total resection was 14.3%. A larger RIM volume at diagnosis was associated with symptomatic presentation (p = 0.007). Younger age at RIM diagnosis was associated with higher tumor growth (RGR ≥ 30%, p = 0.040). A significant correlation was found between the length of latency period and the RGR (p = 0.005).
Conclusion
To diagnose RIM as early as possible comprehensive MRI surveillance is required. Younger patients with shorter latency periods may profit from shortened MRI intervals, with further management being dependent on the growth rate and symptomatology.
Primary aldosteronism without hypertension: A case report and review of the literature
Authors: Dimitrov Yves , Ott J. , Beguin L. , Muller B. 
Published: November 2022

Abstract
We describe the case of a patient who presented with hyperaldosteronism without arterial hypertension. She had been referred for consultation for persistent severe hypokalaemia despite oral KCl supplementation. The absence of hypertension had been proven by repeated clinical measurements and by ABPM. Hyperaldosteronism had been demonstrated by hormonal assays and catheterization of the adrenal veins. Abdominal CT revealed a left adrenal adenoma. Finally, the anatomopathological examination of the surgical specimen confirmed the adenoma. After the intervention, serum potassium normalized. The clinical case is completed by a review of the literature of hyperaldosteronisms without arterial hypertension.
Comprehensive analysis of lncRNA-miRNA-mRNA ceRNA network in exosomes from lipoma tissue reveals differential impacts on biological functions
Authors: Zhou Yuxi , Wang Yujing , Shao Zifei , Wang Xiang , Huang Weiman , Wang Xidi , Li Kun 
Published: November 2022

Abstract

Background Our previous study found that both exosomes from lipoma tissue (Exo-LT) and exosomes from adipose tissue (Exo-AT) can promote the proliferation, migration, and adipogenesis of ADSCs. There is no significant difference between Exo-LT and Exo-AT in promoting the adipogenesis of ADSCs, but Exo-LT has a stronger ability to promote the proliferation and migration of ADSCs than Exo-AT. To elucidate the reason for this difference, we envisioned to explore the gene regulation mechanism of Exo-LT's stronger pro-proliferation effect than Exo-AT by comprehensively analyzing the differential genes between Exo-LT and Exo-AT. Methods Herein, we used high-throughput sequencing technology to analyze the expression of lncRNA, miRNA, and mRNA in Exo-LT and Exo-AT and screen out significantly differentially expressed genes, and then searched mRNAs related to cell proliferation and adipogenesis in GO enrichment and KEGG pathway analysis results for subsequent targeted analysis and construction of ceRNA networks. Results A total of 10 mRNAs were screened that met both significant differential expression conditions (|logFC|>2, p < 0.05) and abundance quality control (CPM༞100), of which 6 were up-regulated in Exo-LT and 4 were down-regulated in Exo-LT. Afterwards in the ceRNA regulatory network, we noticed 5 meaningful lncRNAs that were highly correlated with cell proliferation and adipogenesis, including HOXA11-AS, GAS5, HOTAIR, MALAT1, and PVT1, among which HOXA11-AS was significantly up-regulated in Exo-LT, while GAS5, HOTAIR, MALAT1, and PVT1 were expressed at high levels in both the Exo-LT and Exo-AT group. Interestingly, our follow-up analysis found that many of the lncRNA-miRNA targeting relationships predicted by these 5 lncRNAs in the ceRNA network have been well validated in a large number of previous studies. Conclusions Our first analysis of lncRNA, miRNA, and mRNA expression profiles and ceRNA networks in Exo-LT provides a preliminary explanation for the differences between Exo-LT and Exo-AT in promoting ADSCs proliferation and adipogenesis, as well as a new theoretical basis for the formation mechanism of lipoma tissue.