bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrochemical sensor based on molecularly imprinted copolymer for selective and simultaneous determination of Ascorbic acid and Tyrosine
Authors: Karazan Zahra Mirzaei , Roushani Mahmoud 
Published: November 2022

AbstractThis study reported a novel electrochemical sensor based on molecularly imprinted polymer (MIP) for simultaneous and selective detection of Ascorbic acid (AA) and Tyrosine (Tyr). The MIP film was electropolymerized on the glassy carbon electrode (GCE) using of o-aminophenol (o-AP) and m-dihydroxy benzene (m-DB) as monomers and the dual analyte of AA and Tyr, and its electrochemical performance was evaluated. Influencing parameters such as the pH value, electropolymerization cycle numbers, and template/monomer ratio were optimized. Differential pulse voltammetry (DPV) technique was used for the simultaneous and individual determination of AA and Tyr in their binary mixture. The introduced sensor showed the linear concentration ranges of 0.1–300 µM for AA and 0.01–180 µM for Tyr and good limits of detection were 0.03 µM and 0.003 µM, respectively. The proposed sensor was successfully employed to detect AA and Tyr in real samples.
Bilateral exudative retinal detachment, unusual pattern of uveitis with Multiple sclerosis
Authors: Helal Rehab Sabry , Arya Saket , Sbeit Rami Abu , Elshafei Maha 
Published: November 2022

Abstract
MS associated uveitis used to have limited phenotypes. Bilateral exudative retinal detachment has never been recognized as a pattern of uveitis in such patients. We are here reporting a case of multiple sclerosis who presented initially with the usual pattern of intermediate uveitis and later developed bilateral exudative retinal detachment.
Factors Associated with Anxiety Caused by the Possibility of Infection with Monkeypox in Perú
Authors: Mamani-Benito Oscar , Fernandez Juan Pichén , Vinella-Arzubiaga Daniella , Armada José , Tito-Betancur Madona , Mejia Christia R. 
Published: November 2022

Abstract

Monkeypox is causing great concern due to its great infectious power and the possibility that it could become a new pandemic. The objective of this study was to determine the factors associated with the anxiety produced by the possibility of being infected with monkeypox in Peru. An analytical cross-sectional study was conducted; a previously validated survey was used to measure concern about possible infection and its association with other sociodemographic variables. Of the 779 respondents, 5% mentioned that they were concerned almost all the time about the possibility of being infected with monkeypox. Women, those who always worry and cannot control it and those who are discouraged, depressed or without hope had more anxiety/concern about being infected; in contrast, those who lived on the coast and independent and dependent workers were less concerned. In conclusion, there were important factors that were associated with greater concern for this disease, especially among women and among those who were more anxious or depressed. The findings of this study should be evaluated in other populations to prevent the deterioration of mental health.
How does the 6-month abstinence period fare for patients seeking Liver transplantation? Lessons Learned from Game Theoretic Analysis
Authors: Andhavarapu Sanketh , Saposnik Gustavo , Swistak Piotr T. 
Published: November 2022

Abstract

Background

Patients with alcoholic liver disease are often required to demonstrate a period of abstinence before being eligible for liver transplant. This is known as the 6-month rule. Early liver transplant has shown comparable outcomes in carefully selected patients, yet the 6-month rule is still used in transplant centers worldwide. We applied game theory to evaluate whether the 6-month rule is effective in distinguishing a relapsing patient from a non-relapsing patient during decisions for liver transplant for alcoholic liver diseases.

Methods

We used game theory to model the interactions between alcoholic liver disease patients and transplant physicians. We assumed that patients are either curable or refractory, but the physician does not know which. Patients can either abstain for 6 months or not, thereby signaling their type to the physician. We solved this model for the equilibria under different payoff assumptions.

Results

The equilibria for the models for both patient types resulted in the same equilibria, indicating that the 6-month rule is ineffective in separating the two types of patients. This finding held true for all probabilities of patient relapse and all payoff structures except the unlikely scenario where the cost of abstinence outweighs the benefits of transplant.

Limitations

Our model is based on assumptions, though these assumptions reflect real world preferences and scenarios. We also elected not to analyze other critical factors in the decision-making process for liver transplantation such as the patient’s clinical profile or the physician’s pre-existing biases.

Conclusions

Our game theoretic framework offers a mathematical explanation on why the 6-month abstinence criterion, although seemingly intuitive, is not an effective strategy for identifying LT candidates who would develop an alcohol relapse.
Construction of recombinant Lactococcus expressing thymosin and interferon fusion protein and its application as an immune adjuvant
Authors: Liu Zengqi , Zhang Suhua , Hu Hongjiao , Wang He , Qiu Yu , Dong Mingqi , Wang Muping , Cui Ziyang , Cui Hongyu , Wang Yunfeng , He Gaoming 
Published: November 2022

Abstract
In this study, recombinant food-grade Lactococcus lactis (r-L. lactis-Tα1-IFN) expressing thymosin Tα1 and interferon fusion protein was constructed. In vitro interaction with macrophages showed that recombinant r-L. lactis-Tα1-IFN could significantly activate both macrophage J774-Dual™ NF-κB signaling pathway and IRF signaling pathway. In vitro interaction with chicken, PBMCs showed that recombinant r-L. lactis-Tα1-IFN significantly enhanced the expression levels of IFN-γ, IL-10, CD80, and CD86 molecules in chicken PBMCs cells. Animal experiments showed that injection of recombinant r-L. lactis-Tα1-IFN could significantly activate the proliferation activity of T cells and antigen-presenting cells in chicken PBMCs, and the results of 16S analysis of intestinal microbiota showed that injection of recombinant r-L. lactis-Tα1-IFN could significantly improve the structure and composition of chicken intestinal microbiota, with a significant increase in probiotic genera such as Lactobacillus spp. were significantly increased. The results of animal experiments using recombinant r-L. lactis-Tα1-IFN as an immune adjuvant for inactivated chicken Newcastle disease vaccine showed that the serum HI antibody titers of the experimental group were extremely significantly higher than those of the vaccine control group, and the expression levels of cytokines IFN-γ, IL-2, and IL-10 were significantly higher than those of the vaccine control group, These results indicate that food-safe recombinant r-L. lactis-Tα1-IFN has potential as a vaccine immune booster and immune adjuvant, and this study lays the foundation for the development of natural green novel animal immune booster or immune adjuvant.
Quality seed production to optimize the success of reforestation and agroforestry based on local indigenous forest species: case of Khaya senegalensis (Meliaceae) and Parkia biglobosa (Fabaceae) in West Africa
Authors: Adji Beda Innocent , Letort Véronique , Kang Mengzhen , Wang Xiujuan , De Reffye Philippe , Jaeger Marc , Kouassi Kouadio Henri , Duminil Jérôme , Cilas Christian , Sabatier Sylvie , Akaffou Doffou Sélastique 
Published: November 2022

Abstract

Seed size is a key factor that can affect the regeneration process of plant populations. This study aims to identify efficient seeds that can optimise the cultivation of two overexploited native forest species in Côte d'Ivoire, namely Khaya senegalensis and Parkia bliglobosa. Sets of 1080 seeds per species were tested for their germination and seedling vigour in two distinct environments (dry and humid) in Côte d'Ivoire. The results showed that, for optimized germination, large seeds were preferable for Khaya senegalensis while for Parkia biglobosa, on the contrary, small and medium seeds were preferable. However, the most vigorous seedlings were generated by germinating large seeds regardless of species and study site. In this case, pre-treatment tests on large seeds in Parkia biglobosa are possible to improve their germination performance. Large seeds appear to be the best candidates for high quality, high performance seeds that can optimise the cultivation of Khaya senegalensis (0.25-0.37g) and Parkia biglobosa (0.25-0.37g) in Côte d'Ivoire. They can be provided to farmers to assist in the success of replanting programmes (reforestation and agroforestry) using the target species in Côte d'Ivoire. These results can contribute to the sustainable management of the target species and serve as a basis for restructuring forest regeneration policy in Côte d'Ivoire.
Estimating bank line migration of the Brahmaputra river in the Middle Brahmaputra floodplains of Assam, India using Digital Shoreline Analysis System (DSAS)
Authors: Bhuyan Nirsobha , Sharma Yatendra , Sajjad Haroon , Ahmed Raihan 
Published: November 2022

Abstract

The process of erosion as an inevitable and disastrous mechanism has caused migration of bank lines of rivers globally. In its middle reaches, the Brahmaputra River has eroded many pockets of land, eventually leading to drastic bank line shifting. This study aims to analyze the bank line migration of the Brahmaputra river in the Middle Brahmaputra floodplains of Assam, India, over a period of 30 years (1990-2020) and forecast their future positioning. The study was carried out using digital shoreline analysis system (DSAS). End point rate (EPR) was used to estimate bank line migration over three decades (1990-2000, 2000-2010 and 2010-2020). Both end point rate (EPR) and linear regression rate (LRR) were used for calculating long-term migration from 1990 to 2020. The findings revealed that bank line migration was more prominent along the river’s south bank and the river channel was observed to be migrating in a southward direction. The average shift of the right bank of the river was around -8.15 m/y, 11.83 m/y and -4.5 m/y during 1990-2000, 2000-2010 and 2010-2020 respectively. The left bank of the river showed an erosive trend with an average positional shift of -57.02 m/y, -53.65 m/y and -38.66 m/y during 1990-2000, 2000-2010 and 2010-2020 respectively. The forecasting of the bank lines for 2030 and 2040 showed that the river would likely continue to erode its banks leading to channel widening. The study demonstrated the severity of riverbank erosion and bank line migration processes in the Middle Brahmaputra floodplains. This work might help policymakers find solutions to protect the invaluable lands and lessen the vulnerability of the affected population.
The Relationship between Long-term use of Nonsteroidal Anti-inflammatory Drugs and Kidney Function in Patients with Ankylosing Spondylitis
Authors: Koo Bon San , Hwang Subin , Park Seo Young , Shin Ji Hui , Kim Tae-Hwan 
Published: November 2022

Abstract
Background
Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for ankylosing spondylitis (AS), their effect on kidney function remains unclear. This longitudinal study investigated the correlation between long-term NSAID use and kidney function in patients with AS using electronic medical records.
Methods
The electronic medical records of 1,280 patients with AS collected from a single center between January 2001 and December 2018 were reviewed. The Assessment of Spondyloarthritis International Society (ASAS) NSAID Intake Score was used to determine the cumulative dose of all NSAIDs prescribed for a different time intervals. Each ASAS NSAID Intake Score was obtained for intervals of 6 months, 1 year, 2 years, 3 years, 5 years, and 10 years. The correlation between the ASAS NSAID Intake Score and final estimated glomerular filtration rate (eGFR) for each interval was investigated.
Results
The mean ASAS Intake Scores for 6-month, 1-year, 2-year, 3-year, 5-year, and 10-year intervals were 55.30, 49.28, 44.84, 44.14, 44.61, and 41.17, respectively. At each interval, the pearson correlation coefficients were − 0.018 (95% CI: -0.031 ‒ -0.006, p = 0.004), -0.021 (95% CI: -0.039 ‒ -0.004, p = 0.018), -0.045 (95% CI: -0.071 ‒ -0.019, p = 0.001), -0.069 (95% CI: -0.102 ‒ -0.037, p < 0.001), -0.070 (95% CI: -0.114 ‒ -0.026, p = 0.002), -0.019 (95% CI: -0.099 ‒ 0.062, p = 0.645), respectively. There was a very weak negative relationship between ASAS Intake Score and eGFR at each interval.
Conclusion
Long-term NSAID use did not correlate with kidney function based on real-world data in patients with AS.
Radially Oscillating Incompressible Hyperelastic Multi-layer Tubes: Interface Effects and Energy Approach
Authors: Yucesoy Atacan , Pence Thomas 
Published: November 2022

Abstract
In the context of the extensively studied problem for finite amplitude radial motion of incompressible isotropic hyperelastic cylinders, we consider the effect of material property discontinuity on the response of finite thickness multilayer tubes. This enables explicit characterization of the effect of layer differences (density mismatch, constitutive parameter mismatch (e.g. shear moduli), and interface location). Example demonstration is given in terms of the phase-plane treatment for free oscillation of a two-layer Mooney-Rivlin tube. Equivalent results are then obtained by a fully independent energy treatment which proceeds with no mention of the concept of stress. The second order equation of motion emerges both by a Lagrangian treatment and also by Hamilton's principle.
Evaluation of CMIP5 Decadal Precipitation at Catchment level
Authors: Hossain Md Monowar , Anwar A. H. M. Faisal , Garg Nikhil , Prakash Mahesh , Bari Mohammed 
Published: November 2022

Abstract
The fidelity of the decadal experiment in Coupled Model Intercomparison Project Phase-5 (CMIP5) has been examined, over different climate variables for different temporal and spatial scales, in many previous studies. Most of the studies were, however, for the temperature and temperature-based climate indices. A quite limited study was conducted on precipitation of decadal experiment and no attention was paid to a catchment level. This study evaluates the performances of eight GCMs (MIROC4h, EC-EARTH, MRI-CGCM3, MPI-ESM-MR, MPI-ESM-LR, MIROC5, CMCC-CM, and CanCM4) for the monthly hindcast precipitation of decadal experiment over the Brisbane River catchment in Queensland, Australia. First, the GCMs datasets were spatially interpolated onto a spatial resolution of 0.05o×0.05o (5 km×5 km) matching with the grids of observed data and then were cut for the catchment. Next, model outputs are evaluated for temporal skills, dry and wet periods, and total precipitation (over time and space) based on the observed values. Comparing the skills, models are divided into three categories (Category-I: MIROC4h, EC-EARTH and MRI-CGCM3; Category-II: MPI-ESM-LR and MPI-ESM-MR; and Category-III: MIROC5, CanCM4, and CMCC-CM). Three multi-model ensembles’ mean (MMEMs) are formed using the arithmetic mean of Category-I (MMEM1), Category-I and II (MMEM2), and all eight models (MMEM3). The performances of MMEMs are also assessed using the same skill tests and found MMEM2 performed best which suggests evaluating the models is an important step before the formation of MMEM using GCM models.
Is it meaningful to add mesh reinforcement to laparoscopic fundoplication for esophageal hiatal hernias?
Authors: Tsuboi Kazuto , Masuda Takahiro , Omura Nobuo , Hoshino Masato , Yamamoto Se-Ryung , Akimoto Shunsuke , Sakashita Yuki , Fukushima Naoko , Takeuchi Hideyuki , Takahashi Keita , Yano Fumiaki , Eto Ken 
Published: November 2022

Abstract
Background: While laparoscopic fundoplication is a standard surgical procedure for patients with esophageal hiatal hernias, the postoperative recurrence of esophageal hiatal hernias is a problem for patients with giant hernias, elderly patients, or obese patients. Although there are some reports indicating that reinforcement with mesh is effective, there are differing opinions regarding the use thereof.
Purpose: We investigated whether mesh reinforcement is effective for laparoscopic fundoplication in patients with esophageal hiatus hernias.
Patients and Methods: The subjects included 280 patients who underwent laparoscopic fundoplication as the initial surgery for giant esophageal hiatal hernias, elderly patients aged 75 years or older, and obese patients with a BMI of 28 or higher, who were considered at risk of recurrent hiatal hernias based on the previous reports. Of the subject patients, 91 cases without mesh and 86 cases following the stabilization of mesh use were extracted in order to compare the postoperative course including the pathology, symptom scores, surgical outcome, and recurrence of esophageal hiatus hernias.
Results: The preoperative conditions indicated that the degree of esophageal hiatal hernias was high in the mesh group (p=0.0001), while the preoperative symptoms indicated that the score of heartburn was high in the non-mesh group (p=0.0287). Although the surgical results indicated that the mesh group underwent a longer operation time (p<0.0001) and a higher frequency of intraoperative complications (p=0.037), the rate of recurrence of esophageal hiatal hernia was significantly low (p=0.049), with the rate of postoperative reflux esophagitis also tending to be low (p=0.083).
Conclusions: Mesh reinforcement in laparoscopic fundoplication for esophageal hiatal hernias contributes to preventing the recurrence of esophageal hiatal hernias when it comes to patient options based on these criteria.
Cost-utility analysis of genomic profiling in early breast cancer in Colombia
Authors: Rojas Leonardo , Rojas-Reyes María , Rosselli Diego , Ariza Juan Guillermo , Ruiz-Patiño Alejandro , Cardona Andres F. 
Published: November 2022

Abstract
Background: In Colombia, the best strategy to establish indication for adjuvant chemotherapy in early breast cancer (EBC) remains unknown. This study aimed to identify the cost-utility of Oncotype DX™ (ODX) or Mammaprint™ (MMP) tests to establish the necessity of adjuvant chemotherapy.
Methods: This study used an adapted decision-analytic model to compare cost and outcomes of care between ODX or MMP tests and routine care without ODX or MMP tests (adjuvant chemotherapy for all patients) over a 5-year time horizon from the perspective of the Colombian National Health System (NHS; payer). Inputs were obtained from national unit cost tariffs, published literature, and clinical trial database. The study population comprised women with hormone-receptor-positive (HR+), HER2-negative, lymph-node-negative (LN0) EBC with high-risk clinical criteria for recurrence. The outcome measures were discounted incremental cost-utility ratio (ICUR; 2021 United States dollar per quality-adjusted life-year [QALY] gained) and net monetary benefit (NMB).Probabilistic (PSA) and deterministic sensitivity analysis (DSA) were performed.
Results: ODX increases QALYs by 0.05 and MMP by 0.03 with savings of $2,374 and $554 compared with the standard strategy, respectively, and were cost-saving in cost-utility plane. NMB for ODX was $2,203 and for MMP was $416. Both tests dominate the standard strategy. Sensitivity analysis revealed that with a threshold of 1 gross domestic product per capita, ODX will be cost-utility in 95.5% of the cases compared with 70.2% cases involving MMP.DSA showed that the variable with significant influence was the monthly cost of adjuvant chemotherapy. PSA revealed that ODX was a consistently superior strategy.
Conclusions: Genomic profiling using ODX or MMP tests to define the need of adjuvant chemotherapy treatment in patients with HR+ and HER2− EBC is a cost-utility strategy that allows Colombian NHS to maintain budget.
Primary care physicians and gender medicine: validation of the Italian version of Nijmegen Gender Awareness in Medicine Scale (N-GAMS)
Authors: Gattino Silvia , Molinengo Giorgia , De Piccoli Norma 
Published: November 2022

Abstract
Objective To evaluate the psychometric properties of the Nijmegen Gender Awareness Scale – N-GAMS to the Italian context.
Methods The structure of N-GAMS was evaluated by confirmatory factor analysis (CFA) and its invariance was tested with multigroup techniques The criterion-related validity of the measure was analyzed using the Pearson correlation coefficient with physician empathy and ambivalent sexism
Results 431 Italian physicians (44.5% women; Mage = 50.1) completed the Italian version of N-GAMS along with measures of physician’s empathy and sexism. 311 were primary care physicians and 120 were medical students specializing in primary care. CFA showed that the N-GAMS consists of three factors: Gender Sensitivity (GS), Gender-Role Ideology toward Patients (GRI-P), and Gender-Role Ideology toward Doctors (GRI-D). Multigroup analysis showed that N-GAMS was invariant between women and men and between physicians in service and postgraduate medical students. Finally, N-GAMS showed satisfactory concurrent criterion‑related validity for both physician empathy and ambivalent sexism.
Conclusion This study provides an opportunity to extend current knowledge about the psychometric qualities of the N-GAMS for assessing gender awareness in physicians in training
Practice Implications The Italian version of the N-GAMS appears to be a robust psychological instrument for use in research and clinical settings.
Qos Aware Routing Protocol Using Robust Spatial Gabriel Graph Based Custering Scheme for Adhoc Network
Authors: T.B Sivakumar , Hussain Hasan , G Sugitha 
Published: November 2022

Abstract
MANET (Mobile Ad hoc Network) comprises of a set of wireless mobile node connected in a self-healing and self-configured network devoid of any fixed infrastructure. The major challenge in this ad-hoc network is that the network should adapts the multicast interactions to the condition at which there is an occurrence of infinite flexibility and repeated failures. The cognitive radio (CR) in the MANET system has been developed for addressing this problem of spectrum congestion thereby enabling the cognitive users to utilize the spectrum that are underused in that way mitigating the interference among the users. Also, at the transmission process there is a problem of primary radio’s protection (PRs). In traditional approaches, the problem of transmission process is rectified by employing an optimal solution based on various algorithms and in turn reduces the PRs interference. However, the existing techniques failed to solves the complex convex problem of channel assignment. To address this issue, the proposed protocol is designed. In the proposed scheme, both primary user (PU) and secondary user (SU) are clustered initially based on the graph theory process. After that, in each cluster, formation of Robust spatial Gabriel Graph takes place at which the neighbouring nodes are predicted by estimating the weighted end-to-end delay approach. Once the multi path decision making condition is satisfied, the route path is established, and the communication takes place based on QoS constraint. This RS-GG can easily update their neighbouring list and is capable of adjusting the transmission power. This can lead to the improved rate of PDR, network connectivity maintenance and too enhances the network lifetime. The performance analysis of the proposed methods is carried out in terms of PDR, control overheads, energy consumption, and End-to-End delay and the analysis is compared with existing protocols to compare the variation and to prove the effectiveness of proposed protocol designed. The simulation outcomes illustrate that the suggested strategy performs well and improves the transmission of data with the best optimal solutions.