bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current knowledge of vector-borne zoonotic pathogens in Zambia: A clarion call to scaling-up “One Health” research in the wake of emerging and re-emerging infectious diseases
Authors: Mubemba Benjamin , Mburu Monicah M. , Changula Katendi , Muleya Walter , Moonga Lavel C. , Chambaro Herman M. , Kajihara Masahiro , Qiu Yongjin , Orba Yasuko , Hayashida Kyoko , Sutcliffe Catherine G. , Norris Douglas E. , Thuma Philip E. , Ndubani Phillimon , Chitanga Simbarashe , Sawa Hirofumi , Takada Ayato , Simulundu Edgar 
Published: February 2022

Background
Although vector-borne zoonotic diseases are a major public health threat globally, they are usually neglected, especially among resource-constrained countries, including those in sub-Saharan Africa. This scoping review examined the current knowledge and identified research gaps of vector-borne zoonotic pathogens in Zambia.

Methods and findings
Major scientific databases (Web of Science, PubMed, Scopus, Google Scholar, CABI, Scientific Information Database (SID)) were searched for articles describing vector-borne (mosquitoes, ticks, fleas and tsetse flies) zoonotic pathogens in Zambia. Several mosquito-borne arboviruses have been reported including Yellow fever, Ntaya, Mayaro, Dengue, Zika, West Nile, Chikungunya, Sindbis, and Rift Valley fever viruses. Flea-borne zoonotic pathogens reported include Yersinia pestis and Rickettsia felis. Trypanosoma sp. was the only tsetse fly-borne pathogen identified. Further, tick-borne zoonotic pathogens reported included Crimean-Congo Haemorrhagic fever virus, Rickettsia sp., Anaplasma sp., Ehrlichia sp., Borrelia sp., and Coxiella burnetii.

Conclusions
This study revealed the presence of many vector-borne zoonotic pathogens circulating in vectors and animals in Zambia. Though reports of human clinical cases were limited, several serological studies provided considerable evidence of zoonotic transmission of vector-borne pathogens in humans. However, the disease burden in humans attributable to vector-borne zoonotic infections could not be ascertained from the available reports and this precludes the formulation of national policies that could help in the control and mitigation of the impact of these diseases in Zambia. Therefore, there is an urgent need to scale-up “One Health” research in emerging and re-emerging infectious diseases to enable the country to prepare for future epidemics, including pandemics.
Lung and blood early biomarkers for host-directed tuberculosis therapies: Secondary outcome measures from a randomized controlled trial
Authors: Wallis Robert S. , Ginindza Sibuse , Beattie Trevor , Arjun Nishanee , Likoti Morongwe , Sebe Modulakgotla , Edward Vinodh A. , Rassool Mohammed , Ahmed Khatija , Fielding Katherine , Ahidjo Bintou A. , Vangu Mboyo D. T. , Churchyard Gavin 
Published: February 2022

Background
Current tuberculosis treatments leave most patients with bronchiectasis and fibrosis, permanent conditions that impair lung function and increase all-cause post-TB mortality. Host-directed therapies (HDTs) may reduce lung inflammation and hasten eradication of infection. Biomarkers can accelerate tuberculosis regimen development, but no studies have yet examined early biomarkers of TB-HDTs.

Methods
Biomarkers of inflammation and microbicidal activity were evaluated as a part of a recent phase-2 randomized controlled trial of four HDTs in 200 patients with pulmonary tuberculosis and baseline predictors of poor outcome, including CC-11050 (PDE4i), everolimus (mTORi), auranofin (oral gold salt), and ergocalciferol (vitamin D). Two of the 4 arms (CC-11050 and everolimus) showed superior recovery of lung function at day 180 compared to control; none showed accelerated eradication of MTB infection. Patients underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) on entry and day 56. PET signals were analyzed according to total, maximal, and peak glycolytic activity; CT was analyzed according to total modified Hounsfield units to assess radiodensity. Mycobactericidal activity in ex vivo whole blood culture was measured on days 42, 84, and 140. C-reactive protein (CRP) was measured at multiple time points.

Results
All PET/CT parameters showed highly significant reductions from baseline to day 56; however, only maximal or peak glycolytic activity showed further experimental reduction compared to controls, and only in everolimus recipients. CRP dropped precipitously during early treatment, but did so equally in all arms; over the entire period of treatment, the rate of decline of CRP tended to be greater in CC-11050 recipients than in controls but this fell short of statistical significance. Whole blood mycobactericidal activity in ex-vivo culture was enhanced by auranofin compared to controls, but not by other HDTs.

Conclusions
None of these early biomarkers correctly predicted HDT effects on inflammation or infection across all four experimental arms. Instead, they each appear to show highly specific responses related to HDT mechanisms of action.
A novel pro-oxidant combination of resveratrol and copper reduces transplant related toxicities in patients receiving high dose melphalan for multiple myeloma (RESCU 001)
Authors: Agarwal Anshul , Khandelwal Aakanksha , Pal Kavita , Khare Naveen Kumar , Jadhav Vishal , Gurjar Murarilal , Punatar Sachin , Gokarn Anant , Bonda Avinash , Nayak Lingaraj , Kannan Sadhana , Gota Vikram , Khattry Navin , Mittra Indraneel 
Published: February 2022

Background
Transplant related toxicity is a major therapeutic challenge. We have previously reported that the toxicity of chemotherapy is largely not directly because of the drugs themselves; rather it is mainly due to DNA damage, apoptosis and hyper-inflammation triggered by cell-free chromatin particles that are released because of drug-induced host cell death. Cell-free chromatin particles can be inactivated by free-radicals which are generated when the nutraceuticals resveratrol and copper are administered orally. We investigated if a combination of resveratrol and copper would reduce transplant related toxicities in an exploratory, prospective dose-escalation study.

Patients and methods
Twenty-five patients with multiple myeloma were enrolled between March 2017 to August 2019. Patients were divided into 3 groups: control (Group 1, N = 5) received vehicle alone; group 2 (N = 15) received resveratrol-copper at dose level I (resveratrol = 5.6 mg and copper = 560 ng); group 3 (N = 5) received resveratrol-copper at dose level II (resveratrol = 50 mg and copper = 5 μg). The dose was given twice daily with the first dose administered 48 hours before administering melphalan and continued until day +21 post-transplant. Common Terminology Criteria for Adverse Events version 4.02 was used to assess toxicities which included oral mucositis, nausea, vomiting and diarrhea. Measurement of inflammatory cytokines was done by ELISA.

Results
All patients (100%) in the control group developed grade 3/4 oral mucositis compared to 8/20 (40%) in both resveratrol-copper group 2 plus group 3 combined (P = 0.039). Reduction in inflammatory cytokines: salivary TNF - α (p = 0.012) and IL—1β (p = 0.009) in dose level I but not in dose level II was observed.

Conclusions
A combination of resveratrol-copper reduced transplant related toxicities in patients with multiple myeloma receiving high dose melphalan. We conclude that relatively inexpensive nutraceuticals may be useful as adjuncts to chemotherapy to reduce its toxicity.

Registration
The trial was registered under Clinical Trial Registry of India (no.CTRI/2018/02/011905).
Goal-oriented care for patients with chronic conditions or multimorbidity in primary care: A scoping review and concept analysis
Authors: Boeykens Dagje , Boeckxstaens Pauline , De Sutter An , Lahousse Lies , Pype Peter , De Vriendt Patricia , Van de Velde Dominique ,   on behalf of the Primary Care Academy
Published: February 2022

Background
The healthcare system is faced by an ageing population, increase in chronic conditions and multimorbidity. Multimorbid patients are faced with multiple parallel care processes leading to a risk of fragmented care. These problems relate to the disease-oriented paradigm. In this paradigm the treatment goals can be in contrast with what patients value.
The concept of goal-oriented care is proposed as an alternative way of providing care as meeting patients’ goals could have potential benefits. Though, there is a need to translate this concept into tangible knowledge so providers can better understand and use the concept in clinical practice. The aim of this study is to address this need by means of a concept analysis.

Method
This concept analysis using the method of Walker and Avant is based on a literature search in PubMed, Embase, Cochrane Library, PsychInfo, CINAHL, OTSeeker and Web of Science. The method provides eight iterative steps: select a concept, determine purpose, determine defining attributes, identify model case, identify additional case, identify antecedents and consequences and define empirical referents.

Results
The analysis of 37 articles revealed that goal-oriented care is a dynamic and iterative process of three stages: goal-elicitation, goal-setting, and goal-evaluation. The process is underpinned by the patient’s context and values. Provider and patient preparedness are required to provide goal-oriented care. Goal-oriented care has the potential to improve patients’ experiences and providers’ well-being, to reduce costs, and improve the overall population health. The challenge is to identify empirical referents to evaluate the process of goal-oriented care.

Conclusion
A common understanding of goal-oriented care is presented. Further research should focus on how and what goals are set by the patient, how this knowledge could be translated into a tangible workflow and should support the development of a strategy to evaluate the goal-oriented process of care.
Randomized controlled trial of early, small-volume formula supplementation among newborns: A study protocol
Authors: Ginsburg Amy Sarah , Braima de Sa Augusto , Nankabirwa Victoria , Co Raimundo , Murungi Joanitta , Kim Mi-Ok , Brim Rachel , Namiiro Flavia , Namugga Olive , Hartigan-O’Connor Dennis J. , Roberts Susan B. , Flaherman Valerie 
Published: February 2022

Childhood undernutrition is a major health burden worldwide that increases childhood morbidity and mortality and causes impairment in infant growth and developmental delays that can persist into adulthood. The first weeks and months after birth are critical to the establishment of healthy growth and development during childhood. The World Health Organization recommends immediate and exclusive breastfeeding (EBF). In infants for whom EBF may not meet nutritional and caloric demands, early, daily, small-volume formula supplementation along with breastfeeding may more effectively avoid underweight wasting and stunting in early infancy than breastfeeding alone. The primary objective of this randomized controlled trial is to evaluate the efficacy of formula for 30 days among low birth weight (LBW) infants <6 hours of age and those not LBW with weights <2600 grams at 4 days of age. We will compare breastfeeding and formula (up to 59 milliliters administered daily) through 30 days of infant age vs recommendations for frequent EBF without supplementation, and test the hypothesis that formula increases weight-for-age z-score at 30 days of infant age. The trial will enroll and randomize 324 mother-infant pairs in Guinea-Bissau and Uganda, and follow them for 6 months for outcomes including growth, intestinal microbiota, breastfeeding duration, infant dietary intake, and adverse events. Conservatively estimating 20% loss to follow up, this sample size provides ≥80% power per weight stratum for intervention group comparison to detect a difference of 0.20 with respect to the outcome of WAZ at day 30. This trial was approved by the University of California, San Francisco Institutional Review Board (19–29405); the Guinea-Bissau National Committee on Ethics in Health (Comite Nacional de Etica na Saude, 075/CNES/INASA/2020); the Higher Degrees, Research and Ethics Committee of Makerere University (871); and the Uganda National Council of Science and Technology (HS1226ES). We plan to disseminate study results in peer-reviewed journals and international conferences.
Trial registration number: NCT04704076.
Entre el “crimen atroz” y el “amor terrible”: Poder y violencia enCrónica de una muerte anunciada
Authors: Celis Nadia 
Published: February 2022

ResumenEste artículo es una relectura en clave feminista de las distintas “crónicas” que confluyen en Crónica de una muerte anunciada (1981) de Gabriel García Márquez, con énfasis en la caracterización de su protagonista femenina, la legendaria novia devuelta tras la noche de bodas, Ángela Vicario, y en la mujer cuya tragedia la inspiró, Margarita Chica Salas. Aunque variedad de críticos han explorado los paralelos entre la vida y la ficción en torno al “crimen atroz” que tomó la vida de Santiago Nasar, protagonista de la “muerte anunciada”, pocos han prestado atención a la historia de “amor terrible” que detona el segundo final de la novela, la reconciliación del esposo agraviado con la novia devuelta. Leyendo el texto como “crónica” de las visiones del amor que cimientan los roles y relaciones de género dominantes en las culturas caribeñas y latinoamericanas, mi análisis expone la relación entre las diferentes formas de violencia representadas por la novela, y expande la denuncia implícita del poder que se erige sobre esas violencias a una crítica de los pilares íntimos -afectivos y sexuales—del poder público. Con base en borradores inéditos de la novela, notas periodísticas sobre los personajes reales y entrevistas con testigos, entre otras fuentes poco exploradas, el artículo documenta además las consecuencias ya no solo del crimen real que inspiró la novela sino de su publicación en la vida de Margarita Chica Salas, apuntando a las formas en que la ficción y la realidad se retroalimentan para apropiar el cuerpo, la sexualidad y la autonomía de las mujeres. El involucramiento excepcional del autor en la creación y difusión de esta novela permite asimismo poner a prueba la posición de García Márquez ante las nociones de amor y poder que su obra reproduce. Testimonio de realidades e imaginarios aún vigentes, Crónica es además un cuadro idóneo para evaluar las tareas avanzadas en la agenda crítica feminista hispanoamericana de cara al reto de revisar nuestra educación sentimental y su complicidad con la dominación patriarcal.
Disciplinary Practices and Synchronized Swimming in Mar Gómez Glez’sBajo el agua
Authors: Pasero-O’Malley Anthony 
Published: February 2022

AbstractMar Gómez Glez’s 2014 site-specific and fact-inspired play Bajo el agua portrays the governing presence of the disciplinary mechanisms that operate upon the construction of the female body and feminine subjectivity through the unique focus on the microcosm of synchronized swimming. By deliberately placing a singular emphasis on a sport dominated by women, Gómez Glez calls attention to the gendered nature of disciplinary practices, inviting the reader/spectator to take stock of and better understand the degree of implementation and perpetuation within a wider social frame. This article proposes a reading of Bajo el agua through the theoretical writings of Michel Foucault and Sandra Lee Bartky, employing this critical prism as a means of elucidating the ways in which discipline is both implemented and gendered. My analysis additionally examines the inclusion of elements of performativity as well as the use of multimedia as crucial components of the play’s structural and thematic construction. Gómez Glez’s combination of dramatic fictions and real-life referents, together with contemporary experimental staging techniques further serve to actualize both the form and the content for modern audiences. My reading of Bajo el agua thus stands at the crossroads of studies on feminism, sports sociology, and contemporary theatre practices.
Cruising“Campos de Castilla”: prácticasqueerdel postporno transfeminista
Authors: Liante Ana Almar 
Published: February 2022

ResumenEl presente artículo analiza el corto postporno “Campos de Castilla” (2014), realizado por Karmen Tep y Elena Urko, como una producción audiovisual procedente del activismo transfeminista en el Estado español, fenómeno que apenas ha sido estudiado en la academia estadounidense. El transfeminismo, una corriente del feminismo surgida en España a comienzos de los 2000 y heredera del activismo queer de los años 90, supone una reacción a interpretaciones estrechas del sujeto de representación del feminismo liberal o institucional, reivindicando la proliferación de significados en torno a dicho sujeto así como la consideración de condiciones transversales de opresión. Este análisis resalta cómo “Campos” elabora a nivel audiovisual la intervención crítica del postporno a la producción de sexualidades, cuerpos y deseos heteronormativos característica del porno mainstream, pero además, sitúa al corto dentro de un contexto sociocultural más amplio que destaca las tradiciones cinematográfica y literaria en las que se enmarca este vídeo. Para entender cómo se implementan las micropolíticas de reapropiación del sistema género-sexo-sexualidad, realizaré un close-reading del vídeo a partir de los múltiples niveles y elementos (movimientos de la cámara, puntos de vista, mise-en-scène, sonido, etc.) con los que se juega en “Campos.”
Los muñecos de guiñol en las memorias de guerra de Aurora Arnáiz: una reformulación de la persona legal
Authors: Sedano Nagore 
Published: February 2022

ResumenA partir de la década de 1990, el proyecto de memoria histórica de la Guerra Civil Española se centra principalmente en el marco jurídico de los derechos humanos. Las memorias de la exiliada republicana vasca Aurora Arnáiz (1913-2009), Retrato hablado de Luisa Julián. Memorias de una guerra (1996), se suman a esta tendencia. Arnáiz concluye su obra autobiográfica reclamando justicia por la muerte, a los ocho meses, de su hijo Carlos, y el asesinato, a manos de la policía franquista, de su primer marido, José Cazorla (1906-1940). No obstante, sostengo que lo novedoso de Retrato hablado es que su propuesta jurídica va más allá de la cuestión de impunidad legal de los crímenes franquistas. En este artículo, propongo que el texto autobiográfico de la republicana socialista somete a interrogatorio el cimiento del discurso de los derechos humanos: la persona legal de la tradición política liberal. Esta crítica del sujeto de derecho moderno se logra gracias al tratamiento literario de la figura esperpéntica del muñeco de guiñol. Arnáiz recurre al guiñol en los capítulos que versan sobre la guerra civil para articular sus experiencias más traumáticas. Este artículo propone que las memorias de Arnáiz desestabilizan el discurso de los derechos humanos al dramatizar la fisura entre la ley y el trauma.
The Trouble with Fat: Excess and Desire in Mariana Villegas’s Este cuerpo mío
Authors: Limón Lilia Adriana Pérez 
Published: February 2022

Abstract
The Fat Acceptance Movement, born in the late 1960s with the founding of the civil rights organization, the National Association to Aid Fat Americans, aims to end discrimination against fat people and disrupt the belief that fat bodies are not meant to be visible. This article draws upon the convergence between sexuality, desire, fatness, and disability in Mariana Villegas’s monologue, Este cuerpo mío. Villegas advocates transforming the way we view bodies and understanding fatness in terms of privilege and power, thus envisioning pleasure and sexuality as constituting a rejection of all that has been used to define fat women as undesirable.
Miradas y ojos reconstruidos a partir de accidentes, viajes y retornos en dos geografías: El cuerpo en que nací y Sangre en el ojo
Authors: de Alva María 
Published: February 2022

Resumen
Las novelas El cuerpo en que nací de Guadalupe Nettel (México) y Sangre en el ojo de Lina Meruane (Chile) son autoficciones en las que la voz narrativa queda anclada entre la autora y la narradora-personaje que relata a partir de un ojo marcado; en el primer caso por un lunar y en el segundo, una retinopatía. La mirada narra la experiencia del cuerpo y del ojo desde la exclusión, pero también desde el espacio de la memoria del país ausente al cual se regresa. La tara física define el cuerpo, la identidad personal y la memoria del país.
Reframing Disability through an Ecocritical Perspective in Sara Mesa’s Cara de pan
Authors: Leone Maryanne L. 
Published: February 2022

Abstract
This article establishes a dialogue between disability studies and ecocriticism to analyze Sara Mesa’s novel Cara de pan (2018), which narrates the relationship between a thirteen-year-old girl bullied at school and a fifty-four-year-old man with an atypical appearance who fixates on limited topics. The analysis examines the hegemony of normativity and dominant social narratives about disability, gender, and sexuality. Grounded in the idea that people with disabilities actively intervene in their environment, the essay argues that the characters’ environmental empathy supports the need for a diversity of experiences and perspectives, positively resituating disability and autism.
Pechos dobles (Los míos)
Authors: Arcos Carol 
Published: February 2022

Abstract
Doctora en Estudios Latinoamericanos, ensayista y poeta feminista. Actualmente, es profesora visitante en University of California, San Diego. Su trabajo crítico ha versado sobre historia cultural de la literatura, la edición y la escritura de mujeres en América Latina, como también sobre feminismos, género y sexualidades, desde una perspectiva psicoanalítica. Ha publicado en revistas académicas y en medios masivos, como también capítulos de libros colectivos. Entre sus obras más destacadas, en este ámbito, está la coedición de los cinco volúmenes de la Historia crítica de la literatura chilena (LOM).
Vírgenes y santas: Las devociones católicas en Nuestra Señora de la noche
Authors: Sabogal Alexandra Rodríguez 
Published: February 2022

Resumen
Este ensayo analiza cómo Mayra Santos Febres reinterpreta y recrea las devociones católicas desde las experiencias de marginalización de género, raza y clase. A través de las devociones a vírgenes y santas católicas, Nuestra Señora de la noche recrea una experiencia religiosa menos patriarcal que expande y humaniza el espectro de comportamiento femenino impuesto a las mujeres en la tradición católica. Como interlocutoras de las tres protagonistas, vírgenes y santas revelan discursos privilegiados por la teología patriarcal que naturalizan opresiones de género, raza y clase. Esta reinterpretación literaria centrada en la experiencia religiosa femenina coincide con la teología feminista que interpreta textos y símbolos religiosos desde la perspectiva de género.
Insilio, exilio y falsos idilios: Escritura, amor y nación en Domingo de revolución (2016) de Wendy Guerra
Authors: Santiago-Stommes Ivelisse 
Published: February 2022

Resumen
Este artículo explora cómo Domingo de revolución presenta el acoso que sufre una escritora de renombre internacional por parte del régimen dictatorial en Cuba, el efecto nocivo que el entorno de represión política causa a nivel colectivo y personal y el modo en que el cuerpo y la escritura se prestan como mecanismos de resistencia. Por medio de los desafíos, reacciones y comentarios de la protagonista, la obra cuestiona el concepto tradicional de nación y la nacionalidad cubana, al igual que desafía la autoridad del régimen político para determinar en qué consiste ser cubano y quién forma parte de la nación cubana.