bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can lifestyle change and dietary control improve sexual dysfunction in sexually active men via visceral adiposity index?
Authors: Bolat Mustafa , Kocamanoğlu Fatih , Ozbek Latif , Şahin Bekir , Yılmaz Merve , Gümüş Salih , Dündar Cihad , Asci Ramazan 
Published: February 2022

Abstract
The metabolic syndrome (MeTS) negatively affects male sexual function. Lifestyle changes improve erectile function. However, the effects of lifestyle changes on sexual function in men with and without MeTS on the visceral adiposity index (VAI) have not been adequately investigated. Patients with MeTS (n = 48) and those with no MeTS (n = 31) were recruited. Sexual functions and psychogenic status were assessed using the International Index of Erectile Dysfunction (IIEF) questionnaire and Beck’s depression inventory (BDI), respectively. The VAI was calculated using the gender-specific formula. Demographic, clinical, biochemical and hormonal data were recorded. Participants were advised to 8500 steps per day and dietary control. At least three months later, demographic and biochemical tests were repeated, and the VAI was calculated. Association between sexual functions, presence of MeTS and lifestyle changes via the VAI were analyzed. Each integer increase of the VAI was related to a 1.74-fold increased risk of ED in the MeTS group. The MeTS was related to moderate to severe ED than those with no MeTS (p = 0.033). A 24% decrease of the VAI was recorded in the MeTS group at the end of the study (p = 0.014). The MeTS criteria were disappeared in eight patients at the end of the study, with a slight decrease of VAI (p = 0.07). In the beginning, patients with MeTS and no-MeTS showed similar sexual satisfaction, orgasm, desire, and general satisfaction scores. Sexual satisfaction, orgasm and general satisfaction were improved in the non-MeTS group (p < 0.05). At the end of the study, the MeTS group showed similar sexual satisfaction, desire, orgasm and general satisfaction rates (p > 0.05). Higher VAI levels were related to the lower erectile function scores, particularly in patients with MeTS. Lifestyle changes improved male sexual function scores only in the non-MeTS group. Therefore, fighting against MeTS should be adopted as a global healthcare policy.
Suggesting Time Frequency Representation of the Obtained Reaction Time of the Consecutive Tasks in a Driving Simulator for Determining the Rate of Change of Brain’s Frequency
Authors: Rajdeep Prashant , Patel Lajja , CD Steffy , Panchal Preeti 
Published: February 2022

Abstract
Objective – Suggesting an approach to determine the rate of change of brain’s frequency (ROCOF). Background – Reaction time (RT) is mostly well estimated in any driving simulator, especially the visual reaction time. However, an appropriate representation of RT in a driving simulator can help determine the changes in brain’s frequency. Method – We propose, use a driving simulator which can efficiently measure and record the participant’s reaction times for the rapidly successive tasks in a simulator. A reciprocal presentation of each RT can be used as the brain’s frequency for performing that task. Using this concept, a simulator software can calculate the brain’s frequencies for all the tasks. While its graphical representation over time can yield time frequency distribution (TFD). Results – Analysis of this time frequency representation (TDR) of RT may help to study the pattern of brain activity and to derive ROCOF, which can be used to classify the drivers.
Cryogenic treatment of 7050 Aluminum Alloy to improve corrosion resistance
Authors: Rivolta Barbara , Gerosa Riccardo , Panzeri Davide 
Published: February 2022

Abstract
Cryogenic treatments represent an innovative technology developed with the aim of improving the performance of metallic alloys. The beneficial effects on steels are well documented in the literature, whereas their influence on other materials, such as aluminum alloys, is still not completely clarified. Even if the scientific literature reports conflicting data and conclusions, the industrial applications of such treatments are constantly growing. In the present experimental work, the mechanical and corrosion properties of a high-performance 7050 aluminum alloy were studied after cryogenic treatment at − 196°C in liquid nitrogen. Whereas no appreciable variation was observed in the mechanical resistance, the corrosion tests showed a positive effect of the cryogenic treatment. The microstructure was investigated by FEG-SEM analysis, revealing a different distribution of precipitates near the grain boundaries, which was able to reduce the electrochemical potential difference among these regions and the center-grain.
Novel Hydrothermally Synthesized Strontium Telluride Nanoballs as: Efficient Electrocatalyst for Oxygen Evolution Reaction
Authors: Alharbi F. F. , Manzoor Sumaira , Nisa Mehar Un , Abid Abdul Ghafoor , Aman Salma , Ashiq Muhammad Naeem 
Published: February 2022

Abstract
The engineering of extremely efficient, low-cost, and stable electrocatalysts were required for the sluggish oxygen evolution reaction (OER). Herein, using hydrothermal technique, strontium telluride (SrTe/GC) nanoballs fabricated for water splitting to work efficiently as an efficient OER catalysts. According to physical and chemical characterizations, SrTe/GC nanoballs exhibits a three-dimensional form and homogeneous surface distribution, performing a low overpotential of 268 mV at 10 mA/cm2 with small Tafel slope of 25 mV/dec. The fabricated material exhibits excellent stability of 24 hours with no decline in current density. The Te-induced metallic telluride and substantial covalency around the strontium center is responsible for this catalyst's outstanding performance. This study reveals the valuable insight of metal telluride materials to function as an extraordinarily efficient and stable OER catalysts at high current densities.
In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents
Authors: Suleiman Waleed Bakry , Shehata Reda M. , Younis Ahmed 
Published: February 2022

Abstract
BackgroundInfectious disease is one of the major threats to human especially the current time in which the Covid-19 and its modified forms such as omicron variant, and it is the second leading cause of death worldwide. Edible mushrooms have many valuable nutritional and medicinal properties beneficial to human health. The medicinal properties of edible mushrooms extract in inhibiting pathogenic microorganisms had advantages over the use of antimicrobial chemical compounds, as edible mushrooms extracts are natural, have less unwanted side effects and some can overcome the bacterial resistance. Materials and methodsA strain of Hericium erinaceus was prepared as fruiting bodies for evaluation of its medicinal values. The study hypothesized that the polarity affects the extraction quality of this mushroom and subsequently affects its activity as antioxidant, anti-inflammatory, antimicrobial, antiviral potential. So, the mushroom at first was quantitively evaluated to assess its content of flavonoids, alkaloids, tannins, saponins, carbohydrates, protein, nitrogen, and oil. Results and discussion The current research clarified here that aquatic extract has a significant activity as antioxidant (IC50= 53.7 µg/ml), antiviral (IC50= 24.97 µg/ml) while, ethyl acetate extract showed a reasonable antimicrobial activity rather than all tested extract against tested microorganisms. Unfortunately, all extracts under investigations possess low anti-inflammatory action according to the adopting protocol. The superior results of both water and ethyl acetate extracts were later investigated by HPTLC and GC-MS for preliminary prediction of its chemical constitution of those extracts.Conclusion H. erinaceus mushroom succeeded to establish promising antimicrobial, antiviral, and antioxidant activities while, it has low ani-inflammatory activity. Both HPTLC and GC-MS could identify the chemical constituents of the mushroom crude extract.
Construction of an immune infiltration-associated ceRNA network and prognostic model for low-grade gliomas
Authors: Liu Jing-Yuan , Jing Ming , Liu Yuan-Yu , Zhang Fan , Liu Wen-Ying , Xu Sen 
Published: February 2022

Abstract
Due to the low-grade glioma (LGG) infiltrative nature, it can be challenging to cure patients suffering from this condition only with surgery or multi-drug adjuvant chemotherapy. LGG patients usually have poor prognoses, making the exploration in therapeutic tools and accurate prognosis that are different from traditional ones a novel topic in the medical field. In recent years, the regulation of ceRNA networks in the tumor microenvironment (TME) by immune cell infiltration has generated a research boom, providing new perspectives for tumor treatment and predicting patient prognosis. However, the role of the ceRNA network in regulating the LGG tumor microenvironment is not effectively understood yet. In this study, we obtained LGG patient data with complete survival information from the TCGA database and constructed a novel immune infiltration pattern-related ceRNA regulatory network and a novel prognostic model, which was multi-dimensionally validated to have better predictive features in terms of LGG prognosis. Our study reveals the potential association and clinical significance of the ceRNA network with immune infiltration and survival prediction of these patients.
Gut Microbiota-Regulated Bile Acids Metabolism Features In The Aging Process In Mice
Authors: Luo Duosheng , Chen Kechun , Zhao Yating , Wang Lexun , Yin Yifan , Yang Ling , Rong Xianglu , Guo Jiao 
Published: February 2022

Abstract
Aging is usually characterized with imbalanced gut microbiota and bile acids (BAs) dyshomeostasis. However, the gut microbiota-regulated BA metabolism features in the aging process remains unclear. To establish a direct link between gut microbiota and BA profile changes in the liver, plasma and intestinal contents. UPLC-MS/MS, 16S rDNA sequencing, Western blotting, and HE staining methods were used. The plasma content of TC, TG and LDL-C gradually increased during aging, the Lactobacillus, Bacteroides, Bacillus, Ruminococcus, Blautia and Streptococcus which can produce BSH were increased. The concentration of total BAs was increased, especially unconjugated BAs, and the ratio of unconjugated BAs to conjugated BAs was increased. The expression of bile acid transporter receptors and intestinal tight junction proteins were significantly decreased. The presented data revealed that the changes of BA profile mediated by gut microbiota were closely related to aging, and highlights that prevention and treatment of aging-related disorders, especially disorders of lipid metabolism by targeting gut microbiota-regulated BAs metabolism should be payed more attention. In the current study, we established a direct link between gut microbiota and BA profile changes in the liver, plasma, and intestinal contents, and detected protein expression of bile acid transporter receptors bile salt export pump (BSEP), apical sodium-dependent bile acid transporter (ASBT), multidrug resistance-associated protein 2(MRP2) and intestinal tight junction proteins zonula occludens-1 (ZO-1), Occludin and Claudin-5 during aging. The content of TC, TG and LDL-C in plasma gradually increased during aging, the Lactobacillus, Bacteroides, Bacillus, Ruminococcus, Blautia, and Streptococcus which can produce bacterial enzymes bile salt hydrolase (BSH) were increased. The concentration of total BAs in intestinal contents and plasma was increased, especially the content of unconjugated BAs, and the ratio of unconjugated BAs to conjugated BAs was increased in liver, plasma and intestinal contents. The expression of BSEP and MRP2 in the liver and ASBT in the intestinal were significantly decreased. Meanwhile, the expression of ZO-1, Occludin, and Claudin-5 were decreased. The presented data reveals that the changes of BA profile mediated by gut microbiota was closely related to aging, and highlights that the prevention and treatment of aging-related disorders, especially disorders of lipid metabolism by targeting gut microbiota-regulated BAs metabolism would become a promising therapy for the prevention and treatment of aging.
Development of Rice Variety with Durable and Broad-Spectrum Resistance to Blast Disease Through Marker-Assisted Introduction of Pigm Gene
Authors: Feng Zhiming , Li Mingyou , Wang Xiaoqiu , Wu Keting , Wang Jianan , Xu Zhiwen , Wu Yunyu , Wang Guangda , Zhao Jianhua , Hu Keming , Zhang Yafang , Chen Hongqi , Li Aihong , Chen Zongxiang , Zuo Shimin 
Published: February 2022

Abstract
Rice blast, caused by Magnaporthe oryzae (M. oryzae), is one of the most destructive diseases threatening rice production worldwide. Development of resistant cultivar using broad-spectrum resistance (R) gene with high breeding value is the most effective and economical approach to control this disease. In this study, the breeding potential of Pigm gene in geng/japonica rice breeding practice in Jiangsu province was comprehensively evaluated. Through backcross and marker-assisted selection (MAS), the Pigm was introduced into two geng rice cultivars (Wuyungeng 32/WYG32 and Huageng 8/HG8). In each genetic background, 5 advanced backcross lines with Pigm (ABLs) and same genotypes as the respective recurrent parent in the other 13 known R gene loci were developed. Compared with the corresponding recurrent parent, these ABLs all exhibited stronger resistance in seedling inoculation assay using 184 isolates collected from most rice growing regions of the lower region of the Yangtze River. With respect to panicle blast resistance, all ABLs reached high resistant level to blast disease in three consecutive years’ tests with the inoculation of total 7 mixed-conidial suspensions collected from different regions of Jiangsu province. In natural field nursery assays, the ABLs showed significantly higher resistance than the recurrent parents. No common change on importantly morphological traits and yield-associated components was found among the ABLs, demonstrating the introduction of Pigm had no tightly-linked undesirable effect on rice economically important traits. Notably, one rice line with Pigm, designated as Yangnonggeng3091, had been authorized as a new variety in Jiangsu province in 2021, showing excellent performance on both grain yield and quality as well as the blast resistance. Together, these results suggest that the Pigm gene has a high breeding value in developing rice varieties with durable and broad-spectrum resistance to blast disease.
Vacuum-Assisted Closure Versus On-demand Relaparotomy in Patients With Secondary Peritonitis – the VACOR Trial: Protocol for a Randomized Controlled Trial
Authors: Rajabaleyan Pooya , Michaelsen Jens , Holst Uffe Tange , Möller Sören , Toft Palle , Qvist Niels , Ellebaek Mark Bremholm , Luxhøi Jan , Buyukuslu Musa , Bohm Aske Mathias , Borly Lars , Sandblom Gabriel , Kobborg Martin , Poulsen Kristian Aagaard , Løve Uffe Schou , Ovesen Sophie , Sølling Christoffer Grant , Søndergaard Birgitte Mørch , Persson Lasse , Nielsen Michael Festersen , Lomholt Marianne Lund , Møller Dorthe Ritz 
Published: February 2022

Abstract
Background Secondary peritonitis is a severe condition with a reported mortality of 20–32%. Vacuum-assisted closure (VAC) or primary closure with relaparotomy on-demand (ROD) are the accepted treatment modalities. However, no randomised controlled trial has been conducted comparing the potential benefits and disadvantages of the two methods. MethodsThis study will be a randomised controlled multicentre trial, including patients aged 18 years or older with purulent or faecal peritonitis confined to up to two of the four abdominal quadrants, originating from the small intestine, colon or rectum. Randomisation will be web-based to either primary closure with ROD or VAC in blocks of 2, 4 and 6. The primary endpoint is peritonitis-related complications and comprehensive Complication Index (CCI) within 30 or 90 days and one year after index operation. Secondary outcomes are mortality after 30 or 90 days and one year; quality of life assessment by (SF-36) after three and 12 months, the development of incisional hernia after 12 months as assessed by clinical examination and CT-scanning and healthcare resource utilisation. With an estimated superiority of 15% in the primary outcome for VAC, a total of 340 patients must be included. Hospitals in Denmark and Europe will be invited to participate.Discussion There is no robust evidence for choosing either open abdomen with VAC-treatment or primary closure with relaparotomy on demand in patients with secondary peritonitis. The present study has the potential to answer this important clinical question.Trial Registration The study protocol has been registered at clinicaltrials.gov (NCT03932461).VersionProtocol version 1.0, 9 January 2022.
Gastrointestinal bleeding caused by metastatic testicular choriocarcinoma: a case report and literature review
Authors: Zhang Pengliang , Wang Yu , Xiong Lishou 
Published: February 2022

Abstract
Background: Testicular tumor is one of the common solid tumors in young men. Testicular choriocarcinoma is a non spermatogonial germ cell tumor, which is the most rare of all testicular cancers. Choriocarcinoma usually shows bleeding at the metastatic site, while gastrointestinal involvement is rare. Methods: Here we report a case of testicular choriocarcinoma with gastrointestinal bleeding as the first diagnosis, and summarize the similar cases all over the world in recent 20 years.Results: A 28 year old male was treated with repeated black stools for 2 months. No bleeding foci of stomach, duodenum, colon and rectum were found in endoscopy, and no bleeding foci of digestive tract were found in selective angiography, but space occupying lesions of lung, liver and upper jejunum were found in chest and abdominal CT, Considering the possibility of metastatic tumor and the ineffectiveness of medical treatment, the patient was converted to surgical treatment. The postoperative pathology was consistent with testicular choriocarcinoma. The patient received a chemotherapy regimen of paclitaxel, ifosfamide and cisplatin. At present, the chemotherapy regimen is well tolerated. Conclusions: The case report confirmed that even if we can't find the logical relationship between clinical manifestations and genital examination, genital examination should also be part of the patient's systematic examination.
The Establishment of China Bronchiectasis Registry and Research Collaboration (BE-China): Protocol of a prospective multicenter observational study
Authors: Gao Yonghua , Lu Hai-Wen , Mao Bei , Guan Weijie , Song Yuan-Lin , Li Yuan-Yuan , Wang Dao-Xin , Wang Bin , Gu Hong-Yan , Li Wen , Luo Hong , Wang Ling-Wei , Li Fan , Guo Feng-Xia , Zhang Min , Jie Zhi-Jun , Hang Jing-Qing , Yang Chao , Ren Tao , Yuan Zhi , Meng Qing-Wei , Jia Qin , Chen Yu , Chen Rong-Chang , Qu Jie-Ming , Xu Jin-Fu 
Published: February 2022

Abstract
BackgroundBronchiectasis is a highly heterogeneous chronic airway disease with marked geographic and ethnic variations. Most influential cohort studies to date have been performed in Europe and USA, which serve as the examples for developing a cohort study in China where there is a high burden of bronchiectasis. The Establishment of China Bronchiectasis Registry and Research Collaboration (BE-China) is designed to: (1) describe the clinical characteristics and natural history of bronchiectasis in China and identify the differences of bronchiectasis between the western countries and China; (2) identify the risk factors associated with disease progression in Chinese population; (3) elucidate the phenotype and endotype of bronchiectasis by integrating the genome, microbiome, proteome, and transcriptome with detailed clinical data; (4) facilitate large randomized controlled trials in China.Methods and design:The BE-China is an ongoing prospective, longitudinal, multi-center, observational cohort study which aims to recruit a minimum of 10,000 patients, which was initiated in January 2020 in China. Comprehensive data, including medical history, aetiological testing, lung function, microbiological profiles, radiological scores, comorbidities, mental status, and quality of life (QoL), will be collected at baseline. Patients will be followed up annually for up to 10 years to record longitudinal data on outcomes, treatment patterns and QoL. Biospecimens, if possible, will be collected and stored at -80℃ for further research. Up to October 2021, the BE-China has enrolled 3758 patients from 91 medical centers. The study protocol has been approved by the Shanghai Pulmonary Hospital ethics committee, and all collaborating centers received approvals from their local ethics committee. All patients provided written informed consent to their participation.ConclusionsFindings of the BE-China will be crucial to reveal the clinical characteristics and natural history of bronchiectasis and facilitate evidence-based clinical practice in China.Registration Number in ClinicalTrials.gov: NCT03643653
Immunohistochemical Evaluation of 5-hydroxymethylcytosine (5-hmC) in Breast Phyllodes Tumors
Authors: Vickery Jasmine , Han Lisa , Dzul Stephen , Zhang Wei , Zhang Zhou , Lapadat Razvan , Sattar Husain , Mueller Jeffrey , Krausz Thomas , Biernacka Anna 
Published: February 2022

Abstract
Phyllodes tumors (PTs) pose a significant diagnostic challenge in breast pathology as histological criteria and cutoffs for grading are complex and arbitrary. Nevertheless, the clinical behavior of PTs varies widely and correlates, in part, with the histological grade. Methylation signatures have gained interest as diagnostic and prognostic tools in a variety of neoplasms. In particular, 5-hydroxymethylcytosine (5-hmC) has been found to be a useful biomarker. Herein, we assess 51 PTs of varying grades and 15 cellular fibroadenomas (cFA) for stromal expression of 5-hmC by immunohistochemistry. We demonstrate that nuclear 5-hmC decreases as PT grade increases, correlating with histologic predictors of adverse behavior, while it shows comparable levels in benign PTs and cFAs. We identify thresholds at which reduced 5-hmC levels help to distinguish borderline and malignant PT from their benign counterparts. Our results indicate that 5-hmC may serve as a valuable adjunct in classifying PTs in diagnostically difficult cases.
An Ovarian Large-Cell Neuroendocrine Carcinoma Accompanied by Clear Cell Carcinoma with Specific High Level of AFP: Case Report and Review of the Literature
Authors: Qiu Jian , Yao Guorong , Zhu Fengjia , Wang Yanyan , Xu Jiewei 
Published: February 2022

Abstract
Background
Large cell neuroendocrine carcinoma (LCNEC) is a rare histological subtype of ovarian cancer. A few cases have been reported in literature with high invasiveness and poor prognosis. However, there still have not accepted criteria for diagnosis and treatment of LCNEC.
Case presentation:
We report an unmarried 37 year-old woman who was diagnosed with LCNEC associated with clear cell carcinoma and the tumor index was manifested with a specific increase of AFP. The case received six courses of Etoposide and carboplatin chemotherapy as an adjuvant therapy after primary curative surgery. However, she relapsed within 6 months after surgery and metastasized rapidly to distant organs despite combination chemotherapy of paclitaxel, cisplatin and bevacizumab and died 18 months after primary sugery.
Conclusions
This is the first reported case of LCNEC manifested with a specific increase of AFP and characteristically metastased to the spine as recurrence. Since LCNEC present with aggressive malignancies and can easily metastasize to distance place through hematogenous approach, we recommend that adding Bevacizumab in primary chemotherapy may be beneficial to extend disease-free survival. Further research are needed to find the best treatment of LCNEC so as to improve the prognosis of patients.