bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does short-term exposure to a Neonicotinoid insecticide trigger Biochemical and Physiological responses in Juvenile catfish?
Authors: Erhunmwunse Nosakhare O. , Pajiah Timeyin J. , Victory Ogbodo , Ewere Endurance 
Published: October 2022

Abstract
Imidacloprid is among the most widely used insecticides and may contaminate surface waters, yet there is limited information available on their effects on fish. In the present study, juvenile catfish (Clarias gariepinus) were exposed to 100, 130, 160, and 190 mg/L of imidacloprid for 96 hours, and the effects on mortality, behavior, hepatic and endocrine functions, oxidative stress, and tumor and inflammatory responses were investigated. The 96 hours LC50 was 166.60 (143.38-193.59 95% confidence intervals) mg/L with mortality recorded at concentrations ≥ 130 mg/L. Exposure to imidacloprid induced behavioral alterations and clinical symptoms including gulping, hypoactivity, abnormal surface distribution, loss of buoyancy, and excessive mucus secretion. Furthermore, amylase, lipase, conjugate bilirubin, carbohydrate antigen 19 − 9 (CA 19 − 9), thyroid stimulating hormone (TSH), and glutathione peroxidase (GPx) activity were significantly increased, while significant reductions were observed in triiodothyronine (T3) and superoxide dismutase (SOD) activity. Non-significant changes were observed in aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, 17β- estradiol (E2), thyroxine (T4), C-reactive protein (CRP), glutathione S-transferases (GST), total antioxidant capacity (TAC) and catalase (CAT) activity. Our results demonstrate that imidacloprid causes behavioral, hepatic, and endocrine toxicity in catfish as well as oxidative stress and tumor marker elevation. Our findings show that short-term exposure to imidacloprid triggers biochemical and physiological responses in juvenile catfish.
A Descriptive &amp; clinical study of HIV patients in Damascus and the effect of Dolutegravir &amp; Abacavir on CD4+ titer
Authors: Almouli Rahem , Domirieh Ahmad , Aldahr Nizar , Al-Manasfi Anas 
Published: October 2022

Abstract
Background:
AIDS is one of the diseases of concern worldwide, as the number of people infected with HIV around the world reached about 38.4 million until 2021, and new infections this year were about one and a half million.
Design:
A Cross-Sectional and prospective Study conducted in Syria.
Methods:
(150) HIV patients registered at the AIDS Control Center in Damascus and patients in the septic division of Al-Mowasat University Hospital until 15/8/2022.
Results:
The results were classified in statistical tables and graphs, which we will summarize as follows:
• The largest percentage of AIDS patients in Damascus are males, 80.7%.
• The largest percentage was diagnosed in 2018 and 2019.
• Improved CD4+ values in patients who were put on the current protocol, Dolutegravir+Abacavir.
Renewable energy for productive manufacturing firms in Cameroon: effect of renewable energy on the productivity of manufacturing firms
Authors: KOUMOU ETIENNE LANDRY 
Published: October 2022

Abstract
The objective of this paper is to investigate the effect of renewable energy on the productivity of manufacturing firms in Cameroon. The data used comes from the annual enterprise surveys (EAE) of the National Institute of Statistics (INS) for the 2012–2019 editions. The method used is the two-stage stochastic frontier approach. The results show that renewable energy positively affects the productivity growth of firms. This effect is evaluated at 14.70% for 1% of renewable energy consumed. Despite this positive effect, the productivity growth of these firms remains low over the whole period 21.16%.
Real-time spectral interleaved electro-optic dual-comb spectroscopy
Authors: Xu Bingxin , Fan Xinyu , Wang Shuai , He Zuyuan 
Published: October 2022

Abstract
Optical frequency comb with evenly spaced lines over a broad bandwidth has revolutionized the fields of optical metrology and spectroscopy. Here, we propose a fast interleaved dual comb spectroscopy with sub femtometer resolution and absolute frequency, in which two electro optic frequency combs are swept. Electrically modulated stabilized laser enables ultrahigh resolution of 0.16 fm (or 20 kHz in optical frequency and single shot measurement in 90 ms. Total 20 million points are recorded spanning 3.2 nm (or 400 GHz bandwidth, corresponding to a spectral sampling rate of 2.5 × 10 8 points/s under Nyquist limitation. Besides, considering the trade off between the me asurement time and spectral resolution, a fast single shot measurement is also realized in 1.6 ms with 8 fm (or 1 MHz ) resolution. We demonstrate the 25 averaged result with 30.6 dB spectral measurement signal to noise ratio ( by reducing the filter ba ndwidth in demodulation. The results show great prospect for precise measurement with flexibly fast refresh time, high spectral resolution, and high SNR .
MABAC method based on cumulative prospect theory for multiple attribute group decision making with 2-tuple linguistic Pythagorean fuzzy information
Authors: Zhang Yangjingyu , Gao Hui , Wei Guiwu , Guo Yanfeng 
Published: October 2022

Abstract
With the progress of the times, decision-making problems have become increasingly complex. Under such circumstances, the problems of multiple attribute decision making have emerged. Based on the original MABAC method and its related applications, we propose to apply the MABAC method combined Cumulative Prospect Theory (CPT) with2-tuple linguistic Pythagorean fuzzy numbers (2TLPFNs). In the first place, we show a lot of definitions of Pythagorean fuzzy sets, 2-tuple linguistic Pythagorean fuzzy sets, the 2TLPFWA and 2TLPFWG operators. Next, illustrating calculation formulas according to the score function, the accuracy function and the basic operations of two 2TLPFNs. Afterwards, we simply explain the original MABAC method and the MABAC method with 2TLPFNs (2TLPFN-MABAC) based on the research of other scholars. Besides, we completely give the actual operations of the new method about MABAC method based on CPT for MAGDM with 2TLPFSs (2TLPFN-CPT-MABAC). In the end, by a case study of the assessment of houses, according to the proposed new method and making some comparative analyses among the new method and other methods. In a word, all above are for verifying the effectiveness. In view of the new method with the advantages, MADM problems can be better solved and the new method can be applied to more fields.
Protein PDK4 Interacts with HMGCS2 to Facilitate High Glucoseinduced Myocardial Injuries
Authors: Tan Wenliang , Bao Huogeng , Liu Ziming , Liu Yuanyuan , Hong Lang , Shao Liang 
Published: October 2022

Objectives:As a distinct type of cardiomyopathy, diabetic cardiomyopathy (DCM) is featured as diastolic or systolic cardiac dysfunction in diabetic patients. In order to broaden the understanding of molecular mechanisms in DCM, we intended to explore the mechanism of the interaction between PDK4 protein and Hmgcs2 in high glucose (HG)-induced myocardial damages.Methods:PDK4 and Hmgcs2 expression in the myocardium of diabetes mellitus (DM) model rats and HG-incubated cardiomyocyte line H9C2 was analyzed by western blot analysis. Echocardiography and TUNEL assay were utilized for respective assessment of cardiac structure and function and cardiomyocyte apoptosis in DM rats after silencing PDK4 or/and Hmgcs2. In vitro, the impact of PDK4 and Hmgcs2 on HG-induced cardiomyocyte injuries was identified with cell counting kit-8 and flow cytometry assays, along with detection of LDH release, caspase-3/7 activities, and reactive oxygen species (ROS) and malondialdehyde (MDA) levels. Moreover, a coimmunoprecipitation assay was utilized to test the interaction between PDK4 and Hmgcs2.Results:Both PDK4 and Hmgcs2 were highly expressed in the myocardial tissues of DM rats. Mechanistically, PDK4 interacted with Hmgcs2 to upregulate Hmgcs2 expression in HG-induced H9C2 cells. Silencing PDK4 improved cardiac function and reduced cardiomyocyte apoptosis in DM rats. In HG-induced H9C2 cells, PDK4 or Hmgcs2 silencing enhanced cell viability and reduced LDH release, caspase-3/7 activities, cell apoptosis, and ROS and MDA levels, and these trends were further promoted by the simultaneous silencing of PDK4 and Hmgcs2.Conclusions:In summary, the silencing of PDK4 and Hmgcs2 alleviated HG-induced myocardial injuries through their interaction.
Synthesis, Spectral Characterization, In silico Docking and ADME Prediction
and Biological Evaluation of Novel Piperidin-4-one Derivatives
Authors: Ezhilarasi Muthuvel Ramanathan , Gopalakrishnan Mannathusamy 
Published: October 2022

Abstract:
A novel series of 2, 6-diaryl-3-(4-methylpiperazin-1-yl) piperidin-4-one (2a-2f) derivatives were synthesized. All the synthesized compounds were characterized by FT-IR, NMR, Mass spectrum, and CHN analysis. NMR spectral analyses were performed unambiguously by their one-dimensional (1H NMR and 13C NMR) and two-dimensional (1H-1H COSY and 1H-13C HSQC) NMR. From the NMR spectral data, the compounds (2a-2f) were found to have normal chair conformation with an equatorial orientation of all the phenyl groups at C-2 and C-6 and the piperazine ring at C-3. The target compounds 2a-2f were subjected to insilico docking and ADME prediction. From the result of insilico docking study, compound 2d showed a good docking score (-8.2 kcal/mol) compared to the standard drug ciprofloxacin (-7.8 kcal/mol). The synthesized piperidine-4-one compounds (2a-2f) demonstrated good to moderate activity against gram-positive and gram-negative strains. From the result of insilico ADME prediction, most of the compound exhibited good drug score and good drug likeness property.
A Review on the Synthesis and Pharmacological Activity of
Heterocyclic Compounds
Authors: Baranwal Jyoti , Kushwaha Smriti , Singh Swastika , Jyoti Archana 
Published: October 2022

Abstract:
Biologically active compounds play a very important role in our daily life. Almost all the biologically active compounds contain heteroatoms and among these a major portion are heterocycles. Heterocycles are a significant component in drug development programs. Drugs containing a heterocyclic moiety are highly valued resources in the fight against human and animal diseases and disorders. Some of these compounds are utilized as anticonvulsants antivirals, anti-inflammatory, and central vasodilators, while others are used as nontherapeutic anthelmintics, diuretics, anti-hypertensives, uricosurics, fungicides, bactericides, herbicides. In this review, we have discussed the chemistry of heterocyclic compounds such as Quinoxaline, Triazole, Pyrimidine, Pyridine, Oxadiazole, Thiazole, Indole, and Azepine. Besides some of their recent synthetic methodologies, their pharmaceutical importance is also discussed. Undoubtedly, the contents of this review will motivate readers to do more novel work in this area which will accelerate the journey towards the exploration of the pharmacological activity of heterocyclic compounds.
Preventing Revictimization Through a Web-Based Intervention for Primary Caregivers of Youth in Care (EMPOWERYOU): Protocol for a Randomized Factorial Trial
Authors: Heinrichs Nina , Brühl Antonia 
Published: October 2022

Background
Children in foster care are at a higher risk for relationship problems than their counterparts raised by their biological family because of higher exposure to or prevalence of neglect or maltreatment early in life. Consequently, these children may also show more challenging behavior in their foster families, which in turn increases the parental stress experience of foster caregivers. Furthermore, the children may engage in a vicious cycle of risky relationship behaviors and expectations that put them at a greater risk for revictimization.

Objective
To support foster caregivers in reducing the risk for revictimization, several intervention modules delivered via the internet were developed using a consumer-based approach (phase 1 of the multiphase optimization strategy). This project (phase 2 of the multiphase optimization strategy) aimed to develop a sustainable intervention by selecting promising intervention components based on their contribution to the outcome.

Methods
In a 24 factorial trial, a total of 317 foster caregivers with children aged 8 to 13 years are randomly assigned to 1 of 16 conditions. The primary outcome is the rate of revictimization from baseline to 3 months after intervention. Secondary outcomes include risk-taking and functional behaviors in relationships. All caregivers will receive access to all the intervention components after the follow-up assessment. The participants assigned to the condition with all component levels on are expected to show the best improvement in the primary and secondary outcomes.

Results
Recruitment and data collection for the factorial trial started in March 2022 and is ongoing. As of October 2022, we recruited 181 families. Although it is difficult to predict the exact study timeline owing to COVID-19 pandemic–related delays, results are expected in February 2024.

Conclusions
There is a need for easily accessible information related to raising children in foster care who have experienced early life adversities to interrupt the cycle of violence and enhance the developmental pathway of health and emotional stability. It might be useful, in addition to generally useful parenting information (eg, parental self-care or emotion regulation management), to specifically focus on the needs of these caregivers (eg, how to support the child to reduce dysfunctional relationship behaviors that may have developed because of early adverse experiences).

Trial Registration
ClinicalTrials.gov NCT05235659; https://clinicaltrials.gov/ct2/show/NCT05235659

International Registered Report Identifier (IRRID)
DERR1-10.2196/38183
The Association of Midday Napping With Hypertension Among Chinese Adults Older Than 45 Years: Cross-sectional Study
Authors: Tang Dongfeng , Zhou Yiheng , Long Chengxu , Tang Shangfeng 
Published: October 2022

Background
Hypertension is one of the main public health issues around worldwide, and midday napping is a popular habit. The association between the two remains to be explored.

Objective
The goal of the research was to explore the association of midday napping with hypertension.

Methods
This study separately selected 11,439, 12,689, and 9464 Chinese respondents aged over 45 years from the China Health and Retirement Longitudinal Study 2011, 2015, and 2018 data sets. Binary logistic regression was used to explore the association of midday napping with hypertension, and the 3-step method was used to test the mediation effect of BMI.

Results
Among all respondents, the prevalence rates of hypertension were 24.6% (2818/11439) in 2011, 21.1% (2683/12689) in 2015, and 22.1% (2092/9464) in 2018. Midday napping was positively correlated with hypertension. In 2011 and 2015, napping 60 to 90 minutes had the greatest odds ratios [OR] (OR2011 1.705, OR2015 1.494). In 2018, the biggest OR came from the group napping 30 to 60 minutes (OR 1.223), and ORs of different napping durations decreased from 2011 to 2018. In addition, BMI had a partial mediation effect in 2015 and 2018.

Conclusions
Midday napping is a potential risk factor for hypertension with BMI acting as a mediator. To prevent hypertension, avoiding prolonged duration of midday napping and taking action to maintain a normal BMI level are recommended.
The Effects of the Use of Patient-Accessible Electronic Health Record Portals on Cancer Survivors’ Health Outcomes: Cross-sectional Survey Study
Authors: Liu Piper Liping , Zhao Xinshu , Ye Jizhou Francis 
Published: October 2022

Background
In the past decade, patient-accessible electronic health record (PAEHR) systems have emerged as an important tool for health management both at the hospital level and individual level. However, little is known about the effects of PAEHR portals on the survivorship of patients with chronic health conditions (eg, cancer).

Objective
This study aims to investigate the effects of the use of PAEHR portals on cancer survivors’ health outcomes and to examine the mediation pathways through patient-centered communication (PCC) and health self-efficacy.

Methods
Data for this study were derived from the Health Information National Trends Survey (HINTS 5, Cycle 4) collected from February 2020 to June 2020. This study only involved respondents who reported having been diagnosed with cancer (N=626). Descriptive analyses were performed, and the mediation models were tested using Model 6 from the SPSS macro PROCESS. Statistically significant relationships among PAEHR portal use, PCC, health self-efficacy, and physical and psychological health were examined using bootstrapping procedures. In this study, we referred to the regression coefficients generated by min-max normalization as percentage coefficients (bp). The 95% bootstrapped CIs were used with 10,000 resamplings.

Results
No positive direct associations between PAEHR portal use and cancer survivors’ health outcomes were found. The results supported the indirect relationship between PAEHR portal use and cancer survivors’ psychological health via (1) PCC (bp=0.029; β=.023, 95% CI .009-.054), and (2) PCC and health self-efficacy in sequence (bp=0.006; β=.005, 95% CI .002-.014). Besides, the indirect association between PAEHR portal use and cancer survivors’ physical health (bp=0.006; β=.004, 95% CI .002-.018) via sequential mediators of PCC and health self-efficacy was also statistically acknowledged.

Conclusions
This study offers empirical evidence about the significant role of PAEHR portals in delivering PCC, improving health self-efficacy, and ultimately contributing to cancer survivors’ physical and psychological health.
HIS Implementation in Small Hospital
Authors: Perwirani Resia 
Published: October 2022

Background: Budi Rahayu Hospital at Magelang City has implemented HIS in partnership with the SIMKES FKKMK laboratory of Gadjah Mada University since April 2021. During the initial four months of implementation, Budi Rahayu Hospital experienced various challenges. For understanding and overcome the challenges, it is necessary to construct a strategy of HIS implementation, and then offer a proper recommendation based on study.Methods: This study is a descriptive qualitative with action research design that describe four stages of action research i.e Diagnosing, Planning, Action, and Evaluation. On the Diagnosing stage, Author arrange an interview and discussion with Hospital Team. Next, Author plan a strategy to generate suitable recommendations for the successful implementation of HIS. In the Action stage, author conduct an implementation review and assistance. Author also manage an UAT as a evaluation stage distributed to respondents using a questionnaire. The study is performed by observing of HIS implementation from September – December 2021. The subject of this study is chosen purposively from departments involved, with total 20 end-users respondents on multiple service units to capture data in a real environtment when HIS is used for healthcare services to patients.Results: Strategic actions for smooth implementation is active involvements and collaboration from developer team and hospital team monitored by regional health services. the hospital team and developer team formed an online communication group as a place to discuss the problems encountered. There are monitoring activities that involved by regional health services, so the timeline that has been set runs according to the target and the hospital gets optimal benefits of HIS implementation. System acceptance is important for the further development of HIS. The score of HIS acceptance at Budi Rahayu Hospital is 70% based on 85% scenario that execute successfully. Based on system performance, continues maintenance and communication among implementation team, HIS can be accepted with condition of continuous improvement and adjustment.Conclusions: Active involvements and collaboration from developer team and hospital team, performance improvement and availability of the system is very crucial for user acceptance, satisfaction and overall success of HIS implementation. Keywords: HIS, Implementation, UAT
Factores que inciden en la conducta de compra de productos agroecológicos en Mérida, Yucatán, México
Authors: Bojórquez Carrillo Ana Laura , Flores Anel , Hernández Islas Mireya Noemí , Ortiz Medina Imelda 
Published: October 2022

Objetivo: analizar los motivadores, las barreras y los factores sociodemográficos que inciden en la compra de productos agroecológicos y la relación que existe entre estas variables. El conocimiento de los motivadores y barreras que inciden en la compra de estos productos repercute en los planes y estrategias de mercadotecnia, principalmente de tipo social.
Diseño metodológico: el enfoque de este estudio es cuantitativo, correlacional y transversal. La recopilación de la información se realizó a través de la aplicación de 719 encuestas a clientes potenciales de productos agroecológicos. Los métodos de análisis de la información empleados fueron la estadística descriptiva y la estadística no paramétrica, efectuando pruebas de independencia Chi a partir de las tablas de contingencia cuadrado correspondientes y la obtención de los coeficientes de correlación de Spearman, Tau b de Kendall, y un modelo de regresión logística binaria.
Limitaciones: el trabajo de campo se hizo en el mes de noviembre de 2021, tiempo en el que había restricciones de movilidad impuestas por la pandemia COVID-19, lo que resultó en una alta tasa de rechazo para efectuar las entrevistas personales que se requirieron, por lo que, a pesar de haber logrado la muestra, esta situación puedo haber afectado la representatividad.
Hallazgos: los resultados demuestran que, si el comprador tiene la motivación para contribuir con el medio ambiente o para convertirse en un consumidor responsable es más probable que tenga una alta frecuencia de compra de productos agroecológicos. Asimismo, se observaron los siguientes resultados: a mayor edad de los clientes potenciales, mayor frecuencia de compra; a menor edad de los clientes potenciales, más motivación tienen para elegir los productos agroecológicos si tienen un buen sabor, entre otros.