bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abbreviated Molecular Breast Imaging: Feasibility and Future Considerations
Authors: Maimone Santo , Morozov Andrey P , Letter Haley P , Robinson Kristin A , Wasserman Martha C , Li Zhuo , Maxwell Robert W 
Published: September 2022

Abstract

Objective
Molecular breast imaging (MBI) is a supplemental screening modality consistently demonstrating incremental cancer detection over mammography alone; however, its lengthy duration may limit widespread utilization. The study purpose was to assess feasibility of an abbreviated MBI protocol, providing readers with mediolateral oblique (MLO) projections only and assessing performance in lesion detection and localization.

Methods
Retrospective IRB-exempt blinded reader study administered to 5 fellowship-trained breast imaging radiologists. Independent reads performed for 124 screening MBI cases, half abnormal and half negative/normal. Readers determined whether an abnormality was present, side of abnormality, and location of abnormality (medial/lateral). Abnormal cases had confirmatory biopsy or surgical pathology; normal cases had imaging follow-up ensuring true negative results. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated to assess performance. A false negative result indicated that a reader failed to detect abnormal uptake; a false positive result indicated a reader incorrectly called an abnormality for a negative case. Tests for association included chi-square, Fisher-exact, and analysis of variance.

Results
Mean reader performance for detecting abnormal uptake: sensitivity 96.8%, specificity 98.7%, PPV 98.8%, and NPV 96.9%. Accuracy in localizing lesions to the medial or lateral breast was 100%. There were no associations in reader performance with reader experience, reader technique, lesion morphology, or lesion pathology. Median lesion size was 1.0 cm (range: 0.4–8.0 cm). All readers correctly identified 97.7% (42/43) of lesions with malignant or elevated risk pathology.

Conclusion
An abbreviated MBI protocol (MLO images only) maintained high accuracy in lesion detection and localization.
The mitochondrial genomes of Enoplolambrus validus (De Haan, 1837) and Jonas distinctus (De Haan, 1835) (Decapoda: Brachyura: Parthenopoidea, Corystoidea): a novel gene rearrangement and phylogenetic implications
Authors: Liu Cai-Xin , Gu Tian-Yu , Wang Lu-Yao , Shi Bo-Yang , Wang Ru-Xiao , Pan Da , Sun Hong-Ying 
Published: September 2022

Abstract
A complete mitochondrial genome (mitogenome) of Enoplolambrus validus (De Haan, 1837) (Parthenopoidea) and a near complete mitochondrial genome of Jonas distinctus (De Haan, 1835) (Corystoidea) were sequenced and characterized. Their lengths are 15,431 bp and 16,152 bp, respectively. Both mitogenomes comprise 13 protein-coding genes (PCGs), two ribosomal RNA genes, and 22 transfer RNA genes. A novel gene rearrangement pattern with seven rearranged genes was found in the mitogenome of J. distinctus. The nucleotide compositions of the two mitogenomes are biased towards A/T. The phylogenetic relationship of Brachyura from 57 mitogenomes was reconstructed with two species of Anomura as outgroups by both Bayesian inference and maximum likelihood methods using sequences of 13 protein coding genes. The freshwater crabs, (Gecarcinucoidea and Potamoidea) are sister to species of Thoracotremata. Our results do not support the monophyly of Heterotremata. Enoplolambrus validus and J. distinctus are clustered with species of six other superfamilies but the phylogenetic relationships among these superfamilies are largely unresolved. Our results provide valuable resources for understanding the mitogenome evolutionary pattern and phylogenetic relationships within Brachyura.
Toxicity and prosocial behaviors in massively multiplayer online games: The role of mutual dependence, power, and passion
Authors: Zhu Zicheng , Zhang Renwen , Qin Yuren 
Published: September 2022

AbstractUnderstanding factors that predict toxic and prosocial behavior in massively multiplayer online (MMO) games has drawn a great deal of scholarly attention. Prior work on this topic has primarily focused on individual and technological factors while overlooking the role of interpersonal dynamics. To fill this gap, this study examines if and how players’ perceptions of mutual dependence and power in MMO games are related to toxicity and prosocial behavior in games. Results from a survey of 782 Chinese game players suggest that players’ perceived power is positively related to prosocial behavior in games. Perceived mutual dependence and power are also indirectly related to prosocial and toxic behaviors through players’ passion for games. This study has theoretical implications for scholarship on toxicity, prosocial behaviors, and gameplay, while also providing design and policy implications for MMO games.
Reference genome of the Woolly Sculpin,Clinocottus analis
Authors: Wright Daniel B , Escalona Merly , Marimuthu Mohan P A , Sahasrabudhe Ruta , Nguyen Oanh , Sacco Samuel , Beraut Eric , Toffelmier Erin , Miller Courtney , Shaffer H Bradley , Bernardi Giacomo 
Published: September 2022

AbstractSculpins (Family Cottidae) are generally cold-temperate intertidal reef fishes most commonly found in the North Pacific. As part of the California Conservation Genomics Project (CCGP), we sequenced the genome of the Woolly Sculpin, Clinocottus analis, to establish a genomic model for understanding phylogeographic structure of inshore marine taxa along the California coast. These patterns, in turn, should further inform the design of marine protected areas using dispersal models based on genomic data. The small genome of C. analis is typical of marine fishes at less than 1 Gb (genome size = 538 Mb), and our assembly is near-chromosome level (contig N50 = 9.1 Mb, scaffold N50 = 21 Mb, BUSCO completeness = 97.9%). Within the context of the CCGP, the Woolly Sculpin genome will be used as a reference for future whole-genome resequencing projects aimed at enhancing our knowledge of the population structure of the species, and efficacy of marine protected areas across the state.
Europe’s Human Rights Court rules for the first time on a breach of a copyright holder’s right to property in a private dispute
Authors: Izyumenko Elena 
Published: September 2022

Abstract
The European Court of Human Rights has recently ruled that the domestic courts’ failure to justify the grounds for dismissing the applicant’s copyright infringement claim in a private-party dispute concerning the unauthorized online reproduction of the applicant’s book breached the latter’s human right to property. Notably, the Court was not satisfied with the fact that the national courts had not persuasively explained their conclusions regarding the applicability in the applicant’s case of digital exhaustion and of copyright exceptions for libraries and private copying.
Forest disturbance and occupancy patterns of American ermine (Mustela richardsonii) and long-tailed weasel (Neogale frenata): results from a large-scale natural experiment in Maine, United States
Authors: Evans Bryn E , Mortelliti Alessio 
Published: September 2022

Abstract
Weasels are small mustelid carnivores that play an important role as predators of small mammals in a wide array of ecosystems. However, their response to land use, such as forest harvest for timber products, is seldom the subject of focused research and management projects. Both the American ermine, also known as the short-tailed weasel (Mustela richardsonii), and the long-tailed weasel (Neogale frenata) are native to Maine, United States, where commercial timber harvesting is widespread. The effects of this forest disturbance on weasels are poorly understood, so to contribute toward filling this knowledge gap, we conducted a 4-year, large-scale field study: specifically, our objective was to assess the effects of forest disturbance caused by timber harvest on occupancy patterns of ermines and long-tailed weasels occupancy patterns in Maine. We collected data from 197 survey sites (three camera traps each) over 4 years and analyzed over 7,000 images of weasels using dynamic false-positive occupancy models. We found that American ermines were widely distributed across the state (naïve occupancy at 54% of sites), while long-tailed weasels were rarer (naïve occupancy at 16% of sites). Both species responded positively to forest disturbance, with higher occupancy probabilities as disturbance increased, especially at the larger scales. American ermines were more likely to occupy stands with a higher percentage of conifer trees, while no such relationship was found for long-tailed weasels. We conclude that current forest harvest practices in Maine are not detrimental to weasel populations, but that the two species warrant continued monitoring.
Attitudes towards adherence and deprescribing among polypharmacy patients: a cross-sectional study
Authors: Nusair Mohammad B , Khasawneh Rawand , Al-azzam Sayer , Al-Shuqairat Tala , Khair Zaid M , Arabyat Rasha 
Published: September 2022

Abstract

Objectives
Deprescribing is the process of optimization of medication regimens through cessation of potentially inappropriate or unnecessary medications or adjustment of doses with the goal of managing polypharmacy and improving outcomes. Deprescribing potentially improves adherence by reducing polypharmacy. This study aimed to assess polypharmacy patients’ adherence attitudes and their attitudes towards deprescribing.

Methods
A cross-sectional study that targeted polypharmacy patients at outpatient clinics at King Abdullah University Hospital. The inclusion criteria were (1) patients ≥18 years old, (2) patients taking five or more medications, and (3) patients who do not require a caregiver or assistance at home. We excluded patients that showed any signs of moderate or severe cognitive impairment. Patients who met the inclusion/exclusion criteria were interviewed by a clinical pharmacist and completed two survey instruments: revised Patients’ Attitudes Toward Deprescribing (rPATD) and Adherence Attitude Inventory (AAI).

Key findings
In total, 501 patients took part in this study. Over half of the participants were not satisfied with their current medicines and over 70% of them perceived that their current medications are a burden to them and would like their prescribers to initiate deprescribing. The majority of the participants have low to medium adherence attitudes primarily due to ineffective patient–provider communication. Logistic regression analysis revealed that self-efficacy, commitment to adherence, education and age were significantly associated with participants’ willingness to stop one or more of their medications.

Conclusions
Our findings suggest that polypharmacy patients have negative attitudes towards their medication therapy and favour deprescribing. These reported attitudes had been associated with negative adherence attitudes. Study findings offer schematic direction for future investigations of the role of adherence on key health-related outcomes in patients on polypharmacy. Furthermore, research is warranted to investigate the impact of deprescribing on polypharmacy patients’ medication adherence.
Analysis of the influence of perceived self-efficacy on organizational performance among pharmaceutical managers: a structural equation study
Authors: Ehidiamen Oamen Theophilus 
Published: September 2022

Abstract

Objective
To investigate the influence of perceived self-efficacy on organizational performance among operational, product and strategic managers in the pharmaceutical marketing industry.

Method
A cross-sectional study with a literature-based questionnaire administered to 241 managers proportioned across operational, product and strategic managerial roles using stratified random sampling. Structural equation modeling techniques in the analysis of moment structures software were used to examine causal relations between predictor and outcome variables. Study hypotheses were tested using inferential statistical measures with a P-value of &lt; 0.05.

Key findings
A large number of respondents were operational sales managers (n = 138, 57.3%), followed by strategic managers (n = 64, 25.6%), and the least was product managers (n = 39, 16.2%). The measurement models of self-efficacy, organizational performance constructs and structural models had acceptable measures of fit. Three first-order constructs were derived from the self-efficacy construct namely: self-adaptability (regression coefficient, β = 0.237, P &lt; 0.025), self-efficiency (β = 0.574, P &lt; 0.001), and self-creativity (β = 0.649, P &lt; 0.003). Structural equation modelling revealed a significant positive effect of perceived self-efficacy on organizational performance (R2 = 0.65, β = 0.651, P &lt; 0.003). Simple plot analysis revealed lower performance scores at a moderate level of self-efficacy with operational sales managers compared to strategic and product managers. Multigroup analysis revealed no confounding effect of gender and type of firm on the hypothesized relationship (P &gt; 0.05).

Conclusions
This study contributed another dimension to extant research on the relationship between perceived self-efficacy and performance among pharmaceutical managers. The study suggests targeted management training and collaborative learning for managers to improve their level of self-efficacy. Focal and routine training to enhance work-based competencies, professional development and problem-solving skills of pharmaceutical managers are advocated.
Observations of the October Draconid outburst at different latitudes along 120°E
Authors: Li Yi , Li Guozhu , Hu Lianhuan , Zhao Xiukuan , Sun Wenjie , Xie Haiyong , Yang Sipeng , Ning Baiqi 
Published: September 2022

ABSTRACT
The observations of short-duration meteor showers at different geographic locations are important for well understanding of their outbursts. Using the four all-sky interferometric meteor radars at Mohe (53.49°N, 122.34°E), Beijing (40.3°N, 116.19°E), Wuhan (30.54°N, 114.34°E), and Ledong (18.44°N, 108.97°E) in China, four outbursts (2011, 2012, 2018, and 2019) of the October Draconid meteor shower were observed between 2011 and 2021. The October Draconid meteor velocity was concentrated around 22∼23 km s−1, with an active duration of 6∼9 h and a main peak around the solar longitude 194.73°∼195.63°. When comparing the hourly rates of the October Draconid meteor shower for different years at Mohe, a maximum (minimum) of peak flux was observed in 2012 (2011). The radiants and orbit parameters of the October Draconid meteors derived from the radars at different latitudes are consistent, except that the weighted mean echo height during the peak activity at Mohe was always lower than that at other stations.
Non-gravitational parameters and orbital stability of asteroids in retrograde orbits
Authors: Wlodarczyk I 
Published: September 2022

ABSTRACT
We studied the dynamical evolution of all numbered and selected unnumbered asteroids in a retrograde orbit. We computed the absolute magnitude, size range, and non-gravitational parameters A2 and $Lyapunov\, times$ during the 2 Myr forward and backward orbital evolution of all 21 studied retrograde asteroids. We also studied non-gravitation parameters of 10 unnumbered retrograde asteroids brighter than 18.1 mag. It turns out that the values of A2 are of a similar order as for comets, i.e. on average, a few orders more than in the case of asteroids that are moving in prograde orbits. We investigated how the change of the non-gravitational effect influences the Lyapunov time and the evolution of the semimajor-axis-selected retrograde orbits during the forward and backward integration. We also indicated the roles of Lidov–Kozai resonance in the orbital evolution of the retrograde asteroid.
On the origin and characteristic features of the V1 layer in Venus ionosphere using Akatsuki radio science experiment and the one-dimensional photochemical model
Authors: Ambili K M , Tripathi K R , Choudhary R K , Imamura T 
Published: September 2022

ABSTRACT
Using the radio science experiment onboard the Akatsuki spacecraft and an in-house developed one-dimensional photochemical model (1D-PCM) characteristic features of the V1 layer in Venus ionosphere, which peaks ∼125 km, have been studied. The shape of a V1 layer is highly variable; it can appear from mere as a slope change below the V2 layer to a clear prominent layer peak. We simulated the observations using 1D-PCM and found that the model solar X-ray flux at 1.5–3 nm and 5–10 nm bands need to be enhanced by a factor of 2–4 to reproduce a V1 layer. The model simulations also show that major ions below 135 km are O$_2^+$ and NO+ with O$_2^+$ increasing linearly up to ∼135 km, while NO+ peaks at around 127 km. Our analysis shows that for a case when the V1 layer appears as a slope change below the V2 layer, O$_2^+$ ions are the dominant ions, whereas the NO+ ions are the major ion when a clear V1 peak appears. When both the ion densities are comparable, the layer appears as a ledge.
Mepolizumab administration for eosinophilic granulomatosis with polyangiitis in an elderly patient with an abrupt onset of limb ischaemia and peripheral neuropathy: A case-based literature review
Authors: Terashima Seika , Yamaguchi Makoto , Ishihara Tomomi , Hagita Junichiro , Katsuno Takayuki , Ito Mayumi , Sugiyama Hirokazu , Iwagaitsu Shiho , Nobata Hironobu , Kinashi Hiroshi , Ishimoto Takuji , Banno Shogo , Ito Yasuhiko 
Published: September 2022

ABSTRACT
Eosinophilic granulomatosis with polyangiitis (EGPA) is a type of anti-neutrophil cytoplasmic antibody-associated vasculitis characterised by small- to medium-sized vessel vasculitis and is typically associated with eosinophilic granulomatous inflammation. EGPA can affect any organ system, most commonly the lungs, skin, and the nervous system. However, limb ulcers are rare complications and have only been described in few case reports. Furthermore, no documented cases of EGPA have been treated with mepolizumab. Herein, we report a case of an 86-year-old Japanese woman with anti-neutrophil cytoplasmic antibody-negative EGPA, who had an abrupt onset of upper limb ulcers and bilateral foot drop due to multiple mononeuropathy. Clinicopathological sural nerve biopsy showed eosinophil-associated vascular damage. The patient was administered steroids, intravenous immunoglobulin, vasodilators, and mepolizumab; this resulted in clinical improvement of her finger ulcers and peripheral neuropathy without any adverse effects. In cases of an abrupt onset of limb ischaemia and peripheral neuropathy, physicians should consider the possibility of EGPA as a differential diagnosis. Furthermore, the early administration of mepolizumab might yield better outcomes in terms of improving limb ischaemia and peripheral neuropathy.
High-throughput identification of RNA localization elements in neuronal cells
Authors: Arora Ankita , Castro-Gutierrez Roberto , Moffatt Charlie , Eletto Davide , Becker Raquel , Brown Maya , Moor Andreas E , Russ Holger A , Taliaferro J Matthew 
Published: September 2022

Abstract
Hundreds of RNAs are enriched in the projections of neuronal cells. For the vast majority of them, though, the sequence elements that regulate their localization are unknown. To identify RNA elements capable of directing transcripts to neurites, we deployed a massively parallel reporter assay that tested the localization regulatory ability of thousands of sequence fragments drawn from endogenous mouse 3′ UTRs. We identified peaks of regulatory activity within several 3′ UTRs and found that sequences derived from these peaks were both necessary and sufficient for RNA localization to neurites in mouse and human neuronal cells. The localization elements were enriched in adenosine and guanosine residues. They were at least tens to hundreds of nucleotides long as shortening of two identified elements led to significantly reduced activity. Using RNA affinity purification and mass spectrometry, we found that the RNA-binding protein Unk was associated with the localization elements. Depletion of Unk in cells reduced the ability of the elements to drive RNAs to neurites, indicating a functional requirement for Unk in their trafficking. These results provide a framework for the unbiased, high-throughput identification of RNA elements and mechanisms that govern transcript localization in neurons.
Targeting the TREM1-positive myeloid microenvironment in glioblastoma
Authors: Filippova Natalia , Grimes Jeffrey M , Leavenworth Jianmei W , Namkoong David , Yang Xiuhua , King Peter H , Crowley Michael , Crossman David K , Nabors L Burt 
Published: September 2022

Abstract

Background
Tumor cellular and molecular heterogeneity is a hallmark of glioblastoma and underlies treatment resistance and recurrence. This manuscript investigated the myeloid-derived microenvironment as a driver of glioblastoma heterogeneity and provided a pharmacological pathway for its suppression.

Methods
Transcriptomic signatures of glioblastoma infiltrated myeloid-derived cells were assessed using R2: genomic platform, Ivy Glioblastoma Spatial Atlas, and single-cell RNA-seq data of primary and recurrent glioblastomas. Myeloid-derived cell prints were evaluated in five PDX cell lines using RNA-seq data. Two immunocompetent mouse glioblastoma models were utilized to isolate and characterize tumor-infiltrated myeloid-derived cells and glioblastoma/host cell hybrids. The ability of an inhibitor of HuR dimerization SRI42127 to suppress TREM1+-microenvironment and glioblastoma/myeloid-derived cell interaction was assessed in vivo and in vitro.

Results
TREM1+-microenvironment is enriched in glioblastoma peri-necrotic zones. TREM1 appearance is enhanced with tumor grade and associated with poor patient outcomes. We confirmed an expression of a variety of myeloid-derived cell markers, including TREM1, in PDX cell lines. In mouse glioblastoma models, we demonstrated a reduction in the TREM1+-microenvironment and glioblastoma/host cell fusion after treatment with SRI42127. In vitro assays confirmed inhibition of cell fusion events and reduction of myeloid-derived cell migration towards glioblastoma cells by SRI42127 and TREM1 decoy peptide (LP17) versus control treatments.

Conclusions
TREM1+-myeloid-derived microenvironment promulgates glioblastoma heterogeneity and is a therapeutic target. Pharmacological inhibition of HuR dimerization leads to suppression of the TREM1+-myeloid-derived microenvironment and the neoplastic/non-neoplastic fusogenic cell network.