bluuebunny/crossref_metadata_2025_split huggingface dataset:
Directly Printed Interconnection Wires between Layers for 3D Integrated Stretchable Electronics
Authors: Sun Peng , Zhang Jinbao , Zhu Xiaoyang , Li Hongke , Li Yang , Yang Jianjun , Peng Zilong , Zhang Guangming , Wang Fei , Lan Hongbo 
Published: April 2022

AbstractMultilayer circuits, especially in stretchable electronic devices, are considered to be an effective way to integrate various components and modules for complex functions. However, the existing manufacturing methods for multilayer flexible and stretchable electronics have problems such as complex technology, expensive equipment, and low production efficiency. Here, a direct ink writing 3D printing method is proposed to fabricate multilayer stretchable electronic devices by using high‐viscosity stretchable silver paste as the material for interconnecting wires, and stretchable polydimethylsiloxane as the dielectric layer. The optimal range of printing parameters is explored to realize the stable and repeatable manufacturing of wires. A protective layer is printed on the interconnection wires and rigid components to connect the soft substrate and the rigid electronic components. The results show that stress concentration is reduced and stable electrical response of the device is achieved under more than 49% tensile deformation. Vertical interconnect accesses and arc‐shaped wires are applied to a multilayer flexible thermal imaging display device and a NE555 timer device, and the outcomes prove that the direct ink writing 3D printing method provides an efficient, simple, and low‐cost manufacturing method for fabricating multilayer stretchable electronics.
Empowering Electrochemical Biosensing through Nanostructured or Multifunctional Nucleic Acid or Peptide Biomaterials
Authors: Campuzano Susana , Pedrero María , Barderas Rodrigo , Pingarrón José M. 
Published: April 2022

AbstractElectrochemical biosensors continue to evolve at an astonishing pace, consolidating as competitive tools for determining a wide range of targets and relentlessly strengthening their attributes in terms of sensitivity, selectivity, simplicity, response time, and antifouling ability, making them suitable for getting a foothold in real‐world applications. The design and exploitation of nanostructured or multifunctional nucleic acid or peptide biomaterials are playing a determinant role in these achievements. With the aim of highlighting the potential and opportunities of these biomaterials, this perspective article critically discusses and overviews the electrochemical biosensors reported since 2019 involving nanostructured and multifunctional DNA biomaterials, multifunctional aptamers, modern peptides, and CRISPR/Cas systems. The use of these biomaterials as recognition elements, electrode modifiers (acting as linkers or creating scaffolds with antifouling properties), enzyme substrates, and labeling/carrier agents for signal amplification is discussed through rationally and strategically selected examples, concluding with a personal perspective about the challenges to be faced and future lines of action.
Surface Coupling between Mechanical and Electric Fields Empowering Ni‐Rich Cathodes with Superior Cyclabilities for Lithium‐Ion Batteries
Authors: Dai Zhongsheng , Wang Jianhang , Zhao Huiling , Bai Ying 
Published: April 2022

AbstractNi‐rich cathodes with high energy densities are considered as promising candidates for advanced lithium‐ion batteries, whereas their commercial application is in dilemma due to dramatic capacity decay and poor structure stability stemmed from interfacial instability, structural degradation, and stress–strain accumulation, as well as intergranular cracks. Herein, a piezoelectric LiTaO3 (LTO) layer is facilely deposited onto Li[NixCoyMn1−x−y]O2 (x = 0.6, 0.8) cathodes to induce surface polarized electric fields via the intrinsic stress–strain of Ni‐rich active materials, thus modulating interfacial Li+ kinetics upon cycling. Various characterizations indicate that the electrochemical performances of LTO‐modified cathodes are obviously enhanced even under large current density and elevated temperature. Intensive explorations from in situ X‐ray diffraction technique, finite element analysis, and first‐principle calculation manifest that the improvement mechanism of LTO decoration can be attributed to the enhanced structural stability of bulk material, suppressed stress accumulation, and regulated ion transportation. These findings provide deep insight into surface coupling strategy between mechanical and electric fields to regulate the interfacial Li+ kinetics behavior and enhance structure stability for Ni‐rich cathodes, which will also arouse great interest from scientists and engineers in multifunctional surface engineering for electrochemical systems.
Modulation Doping Enables Ultrahigh Power Factor and Thermoelectric ZT in n‐Type Bi2Te2.7Se0.3
Authors: Chen Cheng‐Lung , Wang Te‐Hsien , Yu Zih‐Gin , Hutabalian Yohanes , Vankayala Ranganayakulu K. , Chen Chao‐Chih , Hsieh Wen‐Pin , Jeng Horng‐Tay , Wei Da‐Hua , Chen Yang‐Yuan 
Published: April 2022

AbstractBismuth telluride‐based thermoelectric (TE) materials are historically recognized as the best p‐type (ZT = 1.8) TE materials at room temperature. However, the poor performance of n‐type (ZT≈1.0) counterparts seriously reduces the efficiency of the device. Such performance imbalance severely impedes its TE applications either in electrical generation or refrigeration. Here, a strategy to boost n‐type Bi2Te2.7Se0.3 crystals up to ZT = 1.42 near room temperature by a two‐stage process is reported, that is, step 1: stabilizing Seebeck coefficient by CuI doping; step 2: boosting power factor (PF) by synergistically optimizing phonon and carrier transport via thermal‐driven Cu intercalation in the van der Waals (vdW) gaps. Theoretical ab initio calculations disclose that these intercalated Cu atoms act as modulation doping and contribute conduction electrons of wavefunction spatially separated from the Cu atoms themselves, which simultaneously lead to large carrier concentration and high mobility. As a result, an ultra‐high PF ≈63.5 µW cm−1 K−2 at 300 K and a highest average ZT = 1.36 at 300–450 K are realized, which outperform all n‐type bismuth telluride materials ever reported. The work offers a new approach to improving n‐type layered TE materials.
Chirality‐Dependent Magnetoelectric Responses in a Magnetic‐Field‐Induced Ferroelectric Phase of Pb(TiO)Cu4(PO4)4
Authors: Kimura Kenta , Katsuyoshi Tsukasa , Miyake Atsushi , Tokunaga Masashi , Kimura Shojiro , Kimura Tsuyoshi 
Published: April 2022

AbstractMagnetoelectric multiferroic materials can exhibit a variety of functional properties such as electric field control of magnetization and nonreciprocal electromagnetic responses. Such a magnetoelectric response may be further enriched by the combination of the magnetoelectric order and a peculiar crystallographic order, such as crystal chirality. Recently, it was reported that a chiral‐lattice magnet Pb(TiO)Cu4(PO4)4 showing a magnetoelectric quadrupole order in its ground state exhibits anomalous chirality‐induced tilt of magnetization vector with respect to an applied magnetic field. In this progress report, additional results that advance the understanding of chirality‐induced tilt of magnetization vector are presented. It is found that chirality‐induced tilt of the magnetization vector also exists in a magnetic‐field‐induced ferroelectric (FI‐FE) phase of this compound that is stabilized in magnetic fields higher than 16 tesla. The resulting transverse component of the magnetization can be switched with an applied electric field through a polarization reversal. The analysis indicates that this transverse component is as large as ≈0.014 μB per f.u, suggesting that the tilting angle of the magnetization in the FI‐FE phase is much larger than that in the low‐field phase. Also, as another research progress, electric field control of nonreciprocal directional dichroism in the FI‐FE phase is demonstrated.
Predictive metabolic networks reveal sex‐ and APOE genotype‐specific metabolic signatures and drivers for precision medicine in Alzheimer's disease
Authors: Chang Rui , Trushina Eugenia , Zhu Kuixi , Zaidi Syed Shujaat Ali , Lau Branden M. , Kueider‐Paisley Alexandra , Moein Sara , He Qianying , Alamprese Melissa L. , Vagnerova Barbora , Tang Andrew , Vijayan Ramachandran , Liu Yanyun , Saykin Andrew J. , Brinton Roberta D. , Kaddurah‐Daouk Rima ,   for the Alzheimer's Disease Neuroimaging Initiative and the Alzheimer's Disease Metabolomics Consortium
Published: April 2022

AbstractIntroductionLate‐onset Alzheimer's disease (LOAD) is a complex neurodegenerative disease characterized by multiple progressive stages, glucose metabolic dysregulation, Alzheimer's disease (AD) pathology, and inexorable cognitive decline. Discovery of metabolic profiles unique to sex, apolipoprotein E (APOE) genotype, and stage of disease progression could provide critical insights for personalized LOAD medicine.MethodsSex‐ and APOE‐specific metabolic networks were constructed based on changes in 127 metabolites of 656 serum samples from the Alzheimer's Disease Neuroimaging Initiative cohort.ResultsApplication of an advanced analytical platform identified metabolic drivers and signatures clustered with sex and/or APOE ɛ4, establishing patient‐specific biomarkers predictive of disease state that significantly associated with cognitive function. Presence of the APOE ɛ4 shifts metabolic signatures to a phosphatidylcholine‐focused profile overriding sex‐specific differences in serum metabolites of AD patients.DiscussionThese findings provide an initial but critical step in developing a diagnostic platform for personalized medicine by integrating metabolomic profiling and cognitive assessments to identify targeted precision therapeutics for AD patient subgroups through computational network modeling.
A graph signal processing‐based multiple model Kalman filter (GSP‐MMKF) tool for predictive analytics: An air separation unit process application
Authors: Ghosh Sambit , Yerimah Lucky E. , Wang Yajun , Cao Yanan , Flores‐Cerrillo Jesus , Bequette B. Wayne 
Published: April 2022

AbstractThe industrial Air Separations Unit (ASU) is a complicated and tightly operated process. The use of dynamic process analytics is also a key element of safe and economic operation of these processes, with increasing focus on predictive analytics to take preemptive actions. With the availability of real‐time data from hundreds of sensors, the data analysis process should also consider the topology of the data, as seen in sensor networks. In this paper, a novel tool is presented that considers the complex connectivity patterns in the sensor network and uses local adaptive disturbance estimations to predict global network‐scale trends. The paper introduces the emerging field of Graph Signal Processing (GSP) and presents a rigorous derivation of the tool starting from the extraction of the sensor‐network (in a graph theoretical sense) from the data. This network, which is in the form of a matrix, is then used to derive a Kalman‐filter type of state‐space model driven by input disturbances. Multiple disturbance models (e.g., step, ramp, periodic) are included to allow the model to have different kinds of disturbance propagation. Each graph node (representing the sensors used) dynamically adapts to the most recent detected disturbance individually. These estimated disturbances are propagated to the global network using the graph. Modifications to ensure stability are also discussed. The fidelity of the tool is tested on certain downtime events and the paper concludes by discussing the advantages of the method and planned future improvements.
Actuation of Liquid Crystalline Elastomers at or Below Ambient Temperature
Authors: Bauman Grant E. , McCracken Joselle M. , White Timothy J. 
Published: April 2022

AbstractLiquid crystal elastomers (LCE) are an emerging class of material actuators. LCE undergo macroscopic dimensional changes when subjected to a stimulus. The large stimuli‐response of LCE is associated with thermotropic disruption of order. Historically, comparatively high temperatures are required to disrupt orientation in LCE to achieve meaningful work output. Here, we introduce an approach to prepare LCE via thiol‐Michael/thiol–ene reactions that actuate at or below ambient temperature. Alignment was imparted to the LCE by mechanical alignment and 3D printing. The LCE materials detailed here achieve strains of 40 % with a maximum deformation rate of 6.5 % °C−1. The functional utility of the tunability of the thermotropic response of these materials is illustrated in reconfiguration triggered via body heat and sequential actuation of a multi‐material element.
Properties of direct coal liquefaction residue water slurry: Effect of mineral matters by acid‐leaching demineralization
Authors: Lv Dongmei , Wu Huijun , Wang Chenyong , Zheng Zhiqi , Zhang Xuejie , Li Jing , Gong Shuwen 
Published: April 2022

AbstractThe effects of demineralization treatment by acid leaching on the properties of direct coal liquefaction residue water slurry (DCLRWS) were investigated. The demineralized direct coal liquefaction residue (DCLR) with different mineral matter content and composition was prepared by leaching with the solution of HCl/HF, HCl, and HF, designated as DEM‐1, DEM‐2, and DEM‐3, respectively. After demineralization, the slurryability of DCLR decreases but their effective solid loading (ash‐free basis) increases. The results indicate that metallic minerals are the principal factor improving the slurryability of DCLRWS, mainly by increasing the dispersant adsorption capacity of DCLR. In addition, the decreasing density of DCLR after demineralization is not advantageous to its slurryability. DCLRWSs prepared by DCLR, DEM‐1, and DEM‐2 all have the same stabilization time (2 days), indicating that removal of metallic minerals could not deteriorate the stability. However, after removal of clay minerals, the slurries prepared by DEM‐3 tend to form sediment after stopping high‐speed stirring, attributed to its lowest zeta potential and loss of stability due to clay minerals. Except for DEM‐3, the slurries prepared by other three samples all have a shear‐thinning behavior, with the strongest behavior observed for DEM‐1 slurry.
Prospects of the Multilateral Cooperation Center for Development Finance (MCDF) to catalyse infrastructure financing
Authors: Nedopil Christoph , Larsen Mathias Lund , Yue Mengdi , Wang Yao 
Published: April 2022

AbstractInitiated in 2017 and formally established in 2020, the Multilateral Cooperation Center for Development Finance (MCDF) is the latest addition to the development finance landscape in Asia. This article provides an in‐depth analysis of MCDFʼs potential to offer additionality in development finance and its political legitimacy by comparing it to 18 development finance and capacity‐building organisations. The article finds that while the MCDF contributes to closing the substantial infrastructure financing gap in Asia, it risks overlapping with existing initiatives to such a degree that it may become an inefficient use of resources while lacking legitimacy as a multilateral organisation due to its unclear relationship with Chinaʼs Belt and Road Initiative. From this outset, and given the climate mandates of its multilateral development bank members, this article finds that if the MCDF focuses specifically on green and climate finance, it could carve out an area where it can become a much‐needed new platform for project development and coordination.
Application of microfluidic technology in antibody screening
Authors: Sun Heng , Hu Ning , Wang Jianhua 
Published: April 2022

AbstractSpecific antibodies are widely used in the biomedical field. Current screening methods for specific antibodies mainly involve hybridoma technology and antibody engineering techniques. However, these technologies suffer from tedious screening processes, long preparation periods, high costs, low efficiency, and a degree of automation, which have become a bottleneck for the screening of specific antibodies. To overcome these difficulties, microfluidics has been developed as a promising technology for high‐throughput screening and high purity of antibody. In this review, we provide an overview of the recent advances in microfluidic applications for specific antibody screening. In particular, hybridoma technology and four antibody engineering techniques (including phage display, single B cell antibody screening, antibody expression, and cell‐free protein synthesis) based on microfluidics have been introduced, challenges, and the future outlook of these technologies are also discussed.
Screening of anti‐atrophic peptides by using photo‐cleavable peptide array and 96‐well scale contractile human skeletal muscle atrophy models
Authors: Yamamoto Kazuki , Ohsumi Saki , Nagashima Takunori , Akiyama Hirokazu , Honda Hiroyuki , Shimizu Kazunori 
Published: April 2022

AbstractSkeletal muscle atrophy is characterized by decreases in protein content, myofiber diameter, and contractile force generation. As muscle atrophy worsens the quality of life, the development of anti‐atrophic substances is desirable. In this study, we aimed to demonstrate a screening process for anti‐atrophic peptides using photo‐cleavable peptide array technology and human contractile atrophic muscle models. We developed a 96‐well system and established a screening process with less variability. Dexamethasone‐induced human atrophic tissue was constructed in the system. Eight peptides were selected from the literature and used for the screening of peptides for preventing the decrease of the contractile forces of tissues. The peptide QIGFIW, which showed preventive activity, was selected as the seed sequence. As a result of amino acid substitution, we obtained QIGFIQ as a peptide with higher anti‐atrophic activity. These results indicate that the combinatorial use of the photo‐cleavable peptide array technology and 96‐well screening system could comprise a powerful approach to obtaining anti‐atrophic peptides, and suggest that the 96‐well screening system and atrophic model represent a practical and powerful tool for the development of drugs/functional food ingredients.
Assessment of Bioactivity‐Modulating Pseudo‐Ring Formation in Psilocin and Related Tryptamines
Authors: Lenz Claudius , Dörner Sebastian , Trottmann Felix , Hertweck Christian , Sherwood Alexander , Hoffmeister Dirk 
Published: April 2022

AbstractPsilocybin (1) is the major alkaloid found in psychedelic mushrooms and acts as a prodrug to psilocin (2, 4‐hydroxy‐N,N‐dimethyltryptamine), a potent psychedelic that exerts remarkable alteration of human consciousness. In contrast, the positional isomer bufotenin (7, 5‐hydroxy‐N,N‐dimethyltryptamine) differs significantly in its reported pharmacology. A series of experiments was designed to explore chemical differences between 2 and 7 and specifically to test the hypothesis that the C‐4 hydroxy group of 2 significantly influences the observed physical and chemical properties through pseudo‐ring formation via an intramolecular hydrogen bond (IMHB). NMR spectroscopy, accompanied by quantum chemical calculations, was employed to compare hydrogen bond behavior in 4‐ and 5‐hydroxylated tryptamines. The results provide evidence for a pseudo‐ring in 2 and that sidechain/hydroxyl interactions in 4‐hydroxytryptamines influence their oxidation kinetics. We conclude that the propensity to form IMHBs leads to a higher number of uncharged species that easily cross the blood‐brain barrier, compared to 7 and other 5‐hydroxytryptamines, which cannot form IMHBs. Our work helps understand a fundamental aspect of the pharmacology of 2 and should support efforts to introduce it (via the prodrug 1) as an urgently needed therapeutic against major depressive disorder.
PROTOCOL: Global elder abuse: A mega‐map of systematic reviews on prevalence, consequences, risk and protective factors and interventions
Authors: Mikton Christopher , Beaulieu Marie , Yon Yongjie , Cadieux Genesse Julien , St‐Martin Kevin , Byrne Mark , Phelan Amanda , Storey Jennifer , Rogers Michaela , Campbell Fiona , Ali Parveen , Burnes David , Band‐Winterstein Tova , Penhale Bridget , Lachs Mark , Pillemer Karl , Estenson Lilly , Marnfeldt Kelly , Eustace‐Cook Jessica , Sutton Anthea , Lacasse Francis 
Published: April 2022

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows: to produce a mega‐map which identifies, maps and provides a visual interactive display, based on systematic reviews on all the main aspects of elder abuse in both the community and in institutions, such as residential and long‐term care institutions.
CO Oxidation Catalytic Effects of Intrinsic Surface Defects in Rhombohedral LaMnO3
Authors: Tapia‐P Juan , Cao Yipeng , Gallego Jaime , Osorio‐Guillén Jorge M. , Morgan Dane , Espinal Juan F. 
Published: April 2022

AbstractThere is an ongoing effort to replace rare and expensive noble‐element catalysts with more abundant and less expensive transition metal oxides. With this goal in mind, the intrinsic defects of a rhombohedral perovskite‐like structure of LaMnO3 and their implications on CO catalytic properties were studied. Surface thermodynamic stability as a function of pressure (P) and temperature (T) were calculated to find the most stable surface under reaction conditions (P=0.2 atm, T=323 K to 673 K). Crystallographic planes (100), (111), (110), and (211) were evaluated and it was found that (110) with MnO2 termination was the most stable under reaction conditions. Adsorption energies of O2 and CO on (110) as well as the effect of intrinsic defects such as Mn and O vacancies were also calculated. It was found that O vacancies favor the interaction of CO on the surface, whereas Mn vacancies can favor the formation of carbonate species.
High gain miniaturrized super‐wideband microstrip patch antenna
Authors: Tewary Tapas , Maity Smarajit , Mukherjee Surajit , Roy Avisankar , Sarkar Partha Pratim , Bhunia Sunandan 
Published: April 2022

SummaryA miniaturized super‐wideband (SWB) monopole antenna is presented in this work. Electrical dimension of the presented antenna is 0.239λ × 0.239λ × 0.0147λ, where λ indicates the wavelength corresponding to the lowest operating frequency. Presented antenna displays single −10 dB operating band from 2.75 to 28 GHz with 164% percentage bandwidth and bandwidth ratio of more than 10:1. The proposed SWB antenna exhibits a large bandwidth dimension ratio (BDR) of 2871 with realized gain of 4.80 dBi. Radiating patch of the proposed antenna is designed by modifying conventional rectangular patch by loading a matching stepwise structure. Further, in order to achieve SWB characteristics, the ground plane is reduced with a loaded rectangular notch for better impedance matching. The designed antenna has the advantages of simple planar miniaturized structure, acceptable gain, and wide bandwidth to support various objectives in modern wireless communication. To boost the maximum gain further over the entire frequency band, the proposed antenna is combined with the proposed frequency selective surface (FSS) which acts as a partially reflector surface. The antenna is placed over 4 × 4 FSS at suitable distance without hampering the obtained bandwidth of the antenna. FSS combined antenna structure, having the physical volume of 56 mm × 56 mm × 26.2 mm, exhibits realized gain of 9.3 dBi which is suitable for long range communication. CST MWS (Microwave studio) for simulation results of the suggested antenna and appropriate Microwave Test bench is used to verify the same.