bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value Propositions of the U.S. Trucking Industry
Authors: RANDALL WESLEY S. , DEFEE C. CLIFFORD , BRADY STEPHAN P. 
Published: June 2022

Abstract
This article uses a method combining analysis of Web site content with the constant comparison process from grounded theory to investigate the value propositions offered by 100 U.S. motor carriers. Using the selling messages of the Web site for these firms, coupled with follow-up interviews, we found that the basic motor carrier value proposition is developed around the four themes of time, place, value management, and value-add. In addition we found underlying capabilities (e.g., type equipment, technology, reliability) that carriers suggest are required to create those value proposition themes. These messages serve an important role in differentiating a firm's offering in a commodity business, like the U.S. motor carrier industry, where price is not a distinguishing factor in most cases. Our findings suggest that many of the sampled firms attempt to avoid price-based commoditization through the value propositions they project.
Efficacy and Safety of Once-Weekly Efpeglenatide Monotherapy Versus Placebo in Type 2 Diabetes: The AMPLITUDE M Randomized Controlled Trial
Authors: Frias Juan Pablo , Choi JaeDuk , Rosenstock Julio , Popescu Luiza , Niemoeller Elisabeth , Muehlen-Bartmer Isabel , Baek Seungjae 
Published: June 2022

<p><em>Objective:</em> To assess the efficacy and safety of the glucagon-like peptide-1 receptor agonist (GLP-1 RA) efpeglenatide versus placebo in patients with type 2 diabetes inadequately controlled with diet and exercise alone. </p>
<p><em>Research design and methods:</em> AMPLITUDE-M was a phase 3, double-blind, placebo-controlled, multicenter trial that randomized adults with type 2 diabetes suboptimally controlled with diet and exercise alone to once-weekly efpeglenatide (2 mg, 4 mg or 6 mg) or placebo for up to 56 weeks. The primary objective was to demonstrate the superiority of efpeglenatide versus placebo for HbA1c reduction at week 30. Secondary objectives included changes in other measures of glycemic control and body weight at weeks 30 and 56. </p>
<p><em>Results:</em> At week 30, HbA1c was reduced from a baseline of 8.1% (65 mmol/mol) to 6.9% (52 mmol/mol), 6.6% (49 mmol/mol) and 6.4% (47 mmol/mol) with efpeglenatide 2, 4 and 6 mg, respectively. Least squares (LS) mean HbA1c reductions from baseline were statistically superior for each efpeglenatide dose versus placebo (2 mg: −0.5% [95% confidence interval [CI] −0.9,−0.2; p=0.0054]; 4 mg: −0.8% [95% CI −1.2,−0.5; p<0.0001]; 6 mg: −1.0% [95% CI −1.4,−0.7; p<0.0001]). A greater proportion of efpeglenatide-treated patients (all doses) achieved HbA1c <7% (53 mmol/mol) versus placebo by week 30 (p<0.0001 for all), and significant reductions in body weight and fasting plasma glucose were also observed for efpeglenatide (4 and 6 mg doses) versus placebo at week 30 (p<0.05 for all). Consistent with the GLP-1 RA class, gastrointestinal adverse events were most commonly reported; these were generally transient and mild/moderate in severity. Few patients reported hypoglycemia.</p>
<p><em>Conclusions:</em> As monotherapy in patients with type 2 diabetes, once-weekly efpeglenatide significantly improved glycemic control and body weight with a safety and tolerability profile similar to other GLP-1 RAs.</p>
Environmental impacts of solar photovoltaic systems: a revision from Life Cycle Assessments and other studies
Authors: Romero Pereira María Carolina , Sánchez Coria Alba 
Published: June 2022

According to the 7th goal of sustainable development concluded by the United Nations (UN), energy should become clean and accessible for every human being on the planet in the upcoming decades. Clean energy is often used as a synonym for renewable, sustainable or green energy, words which are associated with a concept of low-impact technologies. However, renewable energies (REs) also have a set of negative environmental impacts (EIs), which can be identified and assessed through an EI Assessment (EIA) and/or a Life Cycle Assessment (LCA). This article focuses on the revision of EIs documented in LCA studies for solar photovoltaic (PV) systems (SPVSs), the most common type of modern REs to satisfy energy demand globally.
Although different LCA studies include various environmental assessment categories, five categories were selected for analysis, namely global warming potential (GWP), land use, biodiversity loss, human health (HH) and waste generation.
The results show that documented EIs of SPVSs from LCAs depend not only on the technology, context and scale of the project, but also on the objective and scope of each study. Still, this article summarizes orientational values for the GWP, land use and fatal bird accidents related to SPVSs. Further, the research reveals the need for complementary approaches such as EIAs or toxicity studies for the assessment of biodiversity loss as well as the impacts on HH, and the lack of an existing waste management system for the million tons of waste soon to be disposed.
La mercantilización del territorio en el municipio de Huamantla, Tlaxcala, México
Authors: Cabrera Luis Ricardo , Palacio-Aponte Alvaro Gerardo , Vazquez Solís Valente 
Published: June 2022

El turismo en México es un sector económico consolidado, sin embargo, para el estado de Tlaxcala se considera una actividad económica emergente. Pese a esto, la entidad oferta una amplia variedad de atractivos turísticos como la exhacienda premier de San Francisco Soltepec, el Santuario de las Luciérnagas, el pueblo estilo toscano de Val’Quirico, además de los Pueblos Mágicos de Tlaxco y Huamantla. Este artículo explica el proceso de mercantilización del municipio de Huamantla con el fin de adherirse al circuito del mercado turístico nacional. Para tal efecto, se extrajeron indicadores territoriales de los años 2015 y 2021 relacionados con la reconversión del capital, agentes con mayor capacidad de inversión y cambios, tanto en actividades económicas como en el paisaje rural, con el fin de contrastarlos y demostrar la celeridad de dicho proceso. Los resultados hallados indicaron que, si bien Huamantla se inclinó por un perfil turístico a raíz del nombramiento como Pueblo Mágico en 2007, el municipio consolidó la mercantilización del territorio gracias al impulso económico generado por el sector industrial algunos años después. De esta manera, la instalación, a partir del año 2016, de la automotriz Audi y los parques industriales fueron tomados en consideración para el caso de estudio.
Habitus in the context of transfer of students from central Mexico to tourist destinations during the COVID-19 era
Authors: García Lirios Cruz , Quiróz Campas Cellia Yaneth , Espinoza Morales Francisco , Carreón Guillén Javier , Sánchez Sánchez Arturo , Rosas Ferrusca Francisco Javier 
Published: June 2022

Habitus is a disposition towards a risk. In the case of the pandemic, the habitus of transfer and stay suggests contexts that the present work addresses to observe them in a sample of students. A cross-sectional, exploratory, and non-experimental study was carried out. The sample consisted of 100 students with an average age of 20 years old, a monthly income of 1,781.89 USD and an average 150 minutes commute time from residence to school. A structure of five factors that explained the effects of state communication on the use of public transport was found. It is hoped that the model can extend the dimensions of the habitus to other research settings.
Growing Beagles and Foxhound-Boxer-Ingelheim Labrador Retriever mixed breeds show a forelimb-dominated gait and a cranial shift in weight support over time during a kinetic gait analysis
Authors: Mall Sandra U. , Steigmeier-Raith Stephanie , Reese Sven , Meyer-Lindenberg Andrea 
Published: June 2022

Abstract

OBJECTIVE
To collect kinetic gait reference data of dogs of 2 breeds in their growth period during walking and trotting gait, to describe their development, and to investigate the weight support pattern over time.

ANIMALS
8 Foxhound-Boxer-Ingelheim Labrador Retriever mixed breeds and 4 Beagles.

PROCEDURES
Ground reaction force variables (GRFs), peak vertical force and vertical impulse, and temporal variables (TVs) derived therefrom; time of occurrence; and stance times were collected. Body weight distribution (BWD) was evaluated. Six measurements, each containing 1 trial in walking and 1 trial in trotting gait, were taken at age 10, 17, 26, 34, 52, and 78 weeks. The study period started July 17, 2013 and lasted until October 7, 2015. Area under the curve with respect to increase was applied. The difference of area under the curve with respect to increase values between breeds and gaits was analyzed using either the t test or the Mann-Whitney test. Generalized mixed linear models were applied.

RESULTS
Significant differences in gait and breed comparisons were found. Growing dogs showed a forelimb-dominated gait. The development of GRF and TV values over the study period were described.

CLINICAL RELEVANCE
Reference values for GRFs, TVs, and BWDs in growing dogs were given. A cranial shift in weight support over time was found during trotting gait. Smaller, younger dogs walked and trotted more inconsistently.
First report of the presence of enterotoxin gene in coagulase-negative staphylococci recovered from meat of snails (Achatina achatina)
Authors: Okafor Arthur C. , Ogbo Frank C. , Akharaiyi Fred C. , Oladeinde Henry B. 
Published: June 2022

Abstract

Introduction
It has been suggested that coagulase-negative staphylococci can serve as reservoirs of virulence genes for other bacteria. This study assessed the presence of such genes in selected isolates recovered from meat of the giant African snail (Achatina achatina).

Material and Methods
Virulence genes were detected using a polymerase chain reaction targeting specific primers. Two representative isolates were identified using 16S rRNA gene sequencing.

Results
The results showed that the staphylococcal enterotoxin A gene (sea) was present in five out of the eight isolates studied. The isolates expressed resistance mainly to three antibiotics: chloramphenicol, norfloxacin and cloxacillin in descending order of incidence. Most importantly, the Staphylococcus sciuri isolate NEDU 181, in addition to being resistant to the three aforementioned antibiotics, also harboured the sea gene.

Conclusion
Our findings demonstrate, for the first time, the presence of toxigenic and antibiotic-resistant coagulase-negative Staphylococcus spp. in commercially-available fresh snail meat. With staphylococcal enterotoxin A known to survive cooking temperature, this presents a food safety concern.
Metacognitive awareness and emotional resilience in children with Attention Deficit Hyperactivity Disorder
Authors: Ünver Hatice , Rodopman Arman Ayşe , Nur Akpunar Şerife 
Published: June 2022

Abstract

Background
This study explored the metacognitive awareness and emotional resilience levels of children suffering from attention deficit hyperactivity disorder (ADHD) (n=60) with typically developing children (n=30).

Methods
Measures included Metacognitive Awareness Inventory and Resiliency Scales for Children and Adolescents filled out by participants, the List of Adverse Life Events, Turgay DSM-IV-Based Disruptive Behavior Disorders Scale, and Revised Child Anxiety and Depression Scale—Parent Form filled out by parents.

Results
Metacognitive awareness and emotional resilience were found to be low in the children with ADHD. Emotional resilience increases as metacognitive awareness increases. Metacognitive awareness decreased in the presence of heightened ADHD, anxiety, and/or depression symptoms expressed by the parents' questionnaires (p < 0.001, r = −0.438; p < 0.001, r = −0.403; and p < 0.001, r = −0.421).

Conclusions
Findings identified that metacognitive skills and emotional resilience are affected in ADHD.
Evaluation of Anti-inflammatory Activity of Trichosanthes dioica Roxb. Seeds
Authors: Arora Rashmi , Singh Gill Naresh 
Published: June 2022

Inflammation a complex disease associated with various symptoms. These symptoms can be managed with non-steroidal and steroidal anti-inflammatory drugs, which on long term use lead to severe side effects. To overcome this problem, natural products are used as an alternative source of the discovery of new entities to be used as compounds anti-inflammatory compounds. Trichosanthes diocia (T. diocia) belongs to Cucurbitaceae family. T. dioica a dioecious perennial herbaceous vegetable is rich source of vitamin C and minerals. In addition to fruits, leaves and tender shoots have been used in the indigenous system of medicine. The objective of the present study was to evaluate the anti-inflammatory activity of methanolic extract of Trichosanthes dioica seeds for scientific validation of the folklore claim of the plant. The extract was evaluated at three different concentration of 100, 200 and 400 mg/kg, p.o. Significant dose dependent anti-inflammatory activity was observed which was comparable with that of the standard drug indomethacin at dose of 10 mg/kg.
Design And Characterization Of Ceritinib Self- Nanoemulsifying Drug Delivery Systems (SNEDDS)
Authors: Katuri Sujitha , Bhikshapathi Darna 
Published: June 2022

The main objective of the current study was to develop ceritinib SNEDDS for the improvement of solubility, permeability and drug release. Solubility of ceritinib was studied in various oils, surfactants and co-surfactants and based on its maximum solubility an oil, surfactant and co-surfactant were chosen (captex355,tergitol and propylene glycol) and mixed in varying ratios , the ratios with no phase separation, maximum transmittance and clear in appearance were identified and used for plotting pseudo tertiary phase diagram. Fifteen SNEDDS formulations were selected from miscible regions of pseudo ternary phase diagram subjected to thermodynamic stability testing. Formulations that passed stability testing were evaluated for % transmission, drug content and in vitro drug release analysis. The final optimized formulation was analysed for particle size, Z average and zeta potential followed by FTIR and SEM analysis. Formulation F13 with maximum drug release of 98.9% in 60 minutes that is higher than 48 % of pure drug is considered the optimised formulation. The particle size, Z average and zeta potential of the ceritinib SNEDDS formulation F13 were 144 nm, 132 nm and -7.2 mV respectively. The FTIR and SEM studies do not indicate any drug excipient interaction and confirm uniform drug distribution. The formulation subjected to accelerated stability study is proved to be stable over a period of six months. The results indicate ceritinib SNEDDS formulations can be designed in order to enhance the solubility of ceritinib and thereby increase in its absorption rate and drug release.
Development and Optimization of Nefopam hydrochloride Push-Pull Osmotic Pumps by Design of Experiments
Authors: Gorasiya Prashant , Patel VIPUL 
Published: June 2022

Nefopam hydrochloride (NFH) is one of the centrally acting NSAIDs drug used for pain management. The main objective of this research is to study the effect of ratio of Cellulose acetate: Polyethylene glycol (PEG) 3350 and % weight gain in extended release (ER) coating of push-pull osmotic pump (PPOP) tablets, optimized by design of experiment (DoE) using response surface face center (α=1), central composite design having two independent variables at three levels. PPOP tablets of NFH was administer once in a day to reduce dosing frequency and improve patient compliance. PPOP tablets contains drug layer and push layer, compressed in to bilayer tablets which is further coated with cellulose acetate (CA) as semipermeable membrane polymer and PEG 3350 as a plasticizer or pore forming agent. ER coated tablets mechanically drill ~0.50mm on drug layer part for the controlled release of drug up to 24 hrs. Based on the results it can be concluded that the ratio of CA: PEG 3350 and % weight gain in ER coating of PPOP tablets shows significant impact on % drug release. At lower % of PEG, burst release was observed due to cracking of ER coating layer, while at higher % of PEG, slightly rapid release of drug was observed. % Drug release is decrease with increase in the % weight gain of tablets. PPOP Tablets with 10% of PEG 3350 (Ratio of CA:PEG 3350, 90:10) and 8% weight gain exhibits zero order kinetic drug release up to 24 hrs.
Comparative study of herbal bioenhancer containing nano formulation for oral delivery of paclitaxel: pharmacokinetic and cytotoxicity analysis
Authors: SAHU GYANESH KUMAR , SHARMA HARISH , AJAZUDDIN  , Kaur Chanchal Deep 
Published: June 2022

The main objective of this study was to develop novel formulation containing herbal bioenhancer to increase the bioavailability of poorly water-soluble anticancer drug. Paclitaxel (PTX) loaded bioenhancer (Piperine and Quercetin) nanoparticle prepared by emulsification solvent evaporation method by using Eudragit RLPO as a polymer and to evaluate its in-vivo pharmacokinetics (PK) and cytotoxicity studies. The result is reduced oral bioavailability, which limits the use of paclitaxel, a crucial anticancer medication, when taken orally. Though multiple formulation approaches have been taken to fight this low absorption profile but consequence of different herbal bioenhancer, happening CYP3A and P-gp inhibitor on augmentation of bo plasma. Paclitaxel loaded nanoparticles with both bioenhancer used for this study and pharmacokinetic, cytotoxic study (MTT Assay) was used for comparative study. The prepared nanoparticles were evaluated for in vitro cell cytotoxicity study by MTT assay on lung cancer cell line and pharmacokinetic profile. The result revealed good in vitro properties with bioenhancer. The goal of the present work is to asses any modification in oral pharmacokinetics of paclitaxel. Therefore, it can be concluded that addition of bioenhancer with antitumor drug can enhance its prolifertive effect. However, further in vivo studies are recommended to establish the fact.
PEMBERIAN RATIONAL-EMOTIVE BEHAVIOR THERAPY DAN ASSERTIVE TRAINING SEBAGAI UPAYA MENGURANGI PERILAKU AGRESIF PADA REMAJA DI PAUH PADANG
Authors: Sarfika Rika , Afriyeni Nelia , Hermalinda Hermalinda , Feri Fernandes Feri Fernandes 
Published: June 2022

Perilaku agresif remaja di Kota Padang sudah sangat meresahkan dan bahkan sudah mengarah pada tindakan kriminal. Perilaku agresif ini dapat merugikan remaja itu sendiri, keluarga dan lingkungan disekitar mereka. Tujuan kegiatan ini adalah untuk mengurangi perilaku agresif melalui pemberian Rational Emotive-Behavior Therapy (REBT) dan Assertive Training (AT). Peserta kegiatan ini adalah remaja siswa di SMA Negeri 15 Padang dan SMA Negeri 9 Padang. Sebanyak 36 siswa dari 2 sekolah ini diberikan terapi secara berkelompok berdasarkan asal sekolah masing-masing. Kriteria peserta kegiatan adalah siswa dengan perilaku agresif dan bersedia mengikuti terapi REBT dan AT selama 2 minggu. Sebelum dan sesudah pemberian terapi, remaja diberikan kuisioner Agression Questionaire (AQ) untuk mengukur perilaku agresif yang dimiliki remaja. Data dianalisis menggunakan uji t-berpasangan (paired t-test). Hasil analisis data menunjukkan bahwa ada perubahan signifikan dalam perilaku agresif remaja sebelum dan sesudah diberikan REBT-AT. Perubahan signifikan terjadi pada perilaku agresi fisik dan permusuhan. Namun, pada agresi verbal dan kemarahan tidak ada perubahan yang signifikan. Berdasarkan hasil kegiatan, pemberian REBT-AT belum mampu mengurangi semua komponen perilaku agresif yang dimiliki remaja. Idealnya, untuk mendapatkan hasil yang maksimal, terapi harus diberikan selama 4 minggu untuk REBT dan 4 minggu untuk AT. Untuk itu, perlu evaluasi lebih lanjut selama 8 minggu untuk mengetahui apakah program ini berhasil dalam mengatasi perilaku agresif pada kelompok terapeutik ini.
LITERASI VISUAL MEDIA EDUKASI POSTER TERKAIT COVID-19 PADA SISWA SMA DI KOTA PADANG
Authors: Wahyuni Ullya Mega , Rahmadoni Jefril , Kartika Afriyanti Dwi , Arifnur Adi Arga , Kamil Husnil , Silvana Meza , Akbar Ricky , Wahyudi Wahyudi 
Published: June 2022

Secara resmi Organisasi Kesehatan Dunia (WHO) menetapkan bahwa COVID-19 sebagai pandemi dan pemerintah Indonesia juga menetapkan bahwa wabah Corona sebagai bencana Nasional. Untuk bisa melaksanakan berbagai aktivitas di masa pandemi, maka perlu dilakukan Komunikasi, Informasi, dan Edukasi (KIE) kepada masyarakat terkait COVID-19. KIE dapat dilakukan dengan memanfaatkan poster sebagai media komunikasi. Kegiatan ini ditujukan kepada siswa/I SMA yang ada di kota Padang. Tujuan dari kegiatan ini adalah memberikan pelatihan kepada siswa/i SMA yang ada di kota Padang, agar bekal ilmu yang diberikan dapat dimanfaatkan dengan membuat poster edukasi dan menyebarkan informasi terkait COVID-19 kepada masyarakat melalui media sosial sebagai bentuk kepedulian para siswa/i untuk mengurangi penyebaran Virus Corona. Kegiatan ini melibatkan siswa/i dari empat sekolah yang ada di kota Padang yaitu SMAN 7, SMAN 11, SMA Pertiwi 2 dan SMA Don Bosco Padang. Metode pelaksanaan pada kegiatan Pengabdian Kepada Masyarakat ini terdiri dari tiga tahap yaitu persiapan, implementasi, dan evaluasi. Selama kegiatan berlangsung, peserta sangat antusias mengikuti kegiatan sampai tahap akhir. Ketercapaian target dari kegiatan ini adalah 90% dilihat dari peserta yang mengumpulkan hasil poster edukasi selama pelatihan. Sedangkan kemampuan literasi visual peserta sebesar 85%, dinilai dari pemahaman dan pemaknaan pesan visual yang dituangkan ke dalam poster edukasi. Untuk meningkatkan antusias dan semangat kepada peserta agar tetap semangat berkarya secara daring di masa pandemi, maka diadakan pemilihan best poster dari peserta yang ikut kegiatan pengabdian kepada masyarakat.
PENGUATAN KELEMBAGAAN PETANI BARAMBAN DALAM PEMASARAN SAYUR SEHAT BERSERTIFIKAT PRIMA 3 DI KECAMATAN BANUHAMPU KABUPATEN AGAM, SUMATERA BARAT
Authors: Noer Melinda , Herviyanti Herviyanti , Habazar Trimurti , Refdi Cesar Welya 
Published: June 2022

Kelompok Tani Baramban sejak tahun 2014 telah melaksanakan usaha tani sayuran sehat dengan produk sayur yang telah bersertifikat Prima 3. Namun sampai saat ini, pengelolaan usaha tani sayuran sehat oleh Kelompok Tani Baramban di Kecamatan Banuhampu, Kabupaten Agam ini belum banyak mengalami perkembangan usaha tani karena belum terciptanya pasar yang luas dengan harga yang memihak kepada kesejahteraan petani. Penguatan kelembagaan petani dalam pemasaran sayuran sehat dengan demikian menjadi sangat penting dan menjadi elemen penting dalam pengembangan agribisnis sayuran sehat, baik di pasar lokal, nasional, bahkan pasar global. Metode yang digunakan adalah penyuluhan, pembinaan dan pendampingan. Kegiatan ini direncanakan akan dilaksanakan selama lima tahun ke depan, yang dimulai dengan membangun kesepakatan kerjasama dengan kelompok tani Baramban, dimulai tahun 2020. Beberapa alternatif solusi untuk menyelesaikan permasalahan mitra kelompok usaha tani sayuran sehat yang diusulkan dan disepakati oleh Kelompok Tani Baramban adalah sebagai berikut: a. Melakukan kegiatan pendampingan kepada petani sayuran sehat dengan mentransfer daya dari perguruan tinggi melalui keilmuan yang terintegrasi dengan cara pandang agribisnis, b. Pemberdayaan petani dengan basis Penguatan Kelembagaan kelompok agar terbangun aksi kolektif (collective action) yang kemandirian petani untuk menggerakkan pasar sayuran sehat, c. Memfasilitasi petani untuk menciptakan segmen pasar sayuran sehat, melalui pasar modern dan pasar online (online market) dengan teknologi informasi 4.0 dan 4. Membangun kemitraan dengan Transmart sebagai pasar modern berskala nasional dan memiliki jaringan pemasaran berskala global. Kesimpulan adalah bahwa kelompok tani bersedia untuk menjadi partner Tim Pengabdi dalam skim program kemitraan masyarakat membantu usaha berkembang.