bluuebunny/crossref_metadata_2025_split huggingface dataset:
Worry for cancer in association with gastro-esophageal reflux symptoms in patients endoscopically treated for Barrett’s neoplasia. A cross-sectional questionnaire study
Authors: Loon Mirjam van der Ende-van , Nijhuis RAB Oude , Curvers WL , Schoon EJ 
Published: November 2022

Abstract
Background
Endoscopic treatment has become the preferred treatment for (early) neoplasia in a Barrett Esophagus (BE). The diagnoses and treatment of this pre-malignant condition may trigger cancer worry. Reflux symptoms are known as an important factor for negative illness perception on BE. The aim of this study was to assess worry for cancer and reflux symptoms in patients endoscopically treated for a BE (DBE) compared to non-dysplastic BE (NDBE) patients and to patients with reflux symptoms only.
Methods
We performed a cross sectional self-administered questionnaire study using the cancer worry scale, and reflux disease questionnaire.
Results
From October 2019 until July 2021, 192 DBE patients, 213 NDBE patients and 111 refractory reflux symptom patients were included, 76.8% of participants were male and aged 66.9 years. High cancer worry was reported in 40.6% of the DBE patients and 36.2% of NDBE patient. Reflux patients scored significant worse with 56.6% stated high cancer worry. Positive correlations were found between reflux symptoms and cancer worry in NDBE patients (R=.326; p=<.000 N 213) and reflux patients (R=.233; p= .019 N=11)1. In DBE patients correlations were found on higher cancer worry and younger age (R=.-190; p=.009 N 187) and a (family) history of diagnosis of esophageal carcinoma (R= .192; p=0.08 N187).
Conclusions
BE patients reported low cancer worry and good reflux symptom control. Still a significant group of DBE patients reported high cancer worry. Physicians should communicate about the actual cancer risk, which leads to greater patient understanding and may therefore positively affects health outcomes.
Fabrication of dialysis membrane from cotton Giza 86 cellulose di-acetate prepared using Ac2O and NiCl2 as new catalyst
Authors: Ragab Safaa , Sikaily Amany El , Nemr Ahmed El 
Published: November 2022

Abstract
This attempt has been made to synthesis the cellulose di-acetate in solvent-free acetylation system of cotton Giza 86 cellulose with Ac2O (200 and 300 ml) in the presence of NiCl2.6HO (1.0, 1.5 and 2.0 g) as an effectively available and new catalyst by the conventional reflux and microwave irradiation methods. This study, also illustrates the preparation of dialysis membrane which made from a cellulose di-acetate–dichloromethane- methanol-polyethylene glycol (MW: 200) casting solution. The microwave irradiation method for synthesis of cellulose di-acetate showed excellent yields and short reaction time, which is the important feature of this method. The impact of the two methods on the cellulose di-acetate formation and its used in the dialysis membrane formulations was studied. The experimental degree of substitution of the prepared cellulose di-acetate values (DS = 2.00-2.7) showed an agreement with the calculated values by FTIR and 1H-NMR analysis methods. The formation of cellulose di-acetate with percentage yields varied from 62.85 to 89.85%. The applicability of the prepared membrane in dialysis operation was evaluated in terms of urea clearance, rejection of Bovine Serum Albumin (BSA) and flux of pure water. Characterization of cellulose di-acetate was achieved through 1H-NMR, FTIR, TGA, and BET analyses. The CA-PEG blend membrane was examined by contact angle measurement, porosity, and water uptake of membrane. The cellulose acetate membrane surface morphology was determined using SEM. It is observable that, the fabricated CA-PEG blend membrane from synthesized cellulose di-acetate by using Nickel chloride as a catalyst is showing remarkably rejection of BSA and urea clearance up to 100 and 67.2%, respectively. Definitely, the present work is promising and also, applicable in dialysis membrane.
Clinical Outcomes of Acute Myocardial Infarction Arising from Non-lipid-rich Plaque determined by NIRS-IVUS
Authors: Terada Kosei , Wakana Noriyuki , Kubo Takashi , Ino Yasushi , Khalifa Amir Kh. M. , Fujita Suwako , Takahata Masahiro , Shiono Yasutsugu , Madder Ryan D. , Kameyama Takeyoshi 
Published: November 2022

Abstract
Aims. Pathological studies have suggested that acute myocardial infarction (AMI) can be caused by plaque erosion with small or no evidence of a lipid-core. This study sought to compare the clinical outcomes after percutaneous coronary intervention (PCI) between AMI showing maximum lipid-core burden index in 4 mm (maxLCBI4mm) <400 and ≥400 in the infarct-related lesions assessed by near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS).
Methods and results. We investigated 426 AMI patients who underwent NIRS-IVUS in the infarct-related lesions before PCI. Major adverse cardiovascular events (MACE) were defined as the composite of cardiac death, non-fatal MI, clinically driven target lesion revascularization (TLR), clinically driven non-TLR, and congestive heart failure requiring hospitalization. 107 (25%) patients had infarct-related lesions of maxLCBI4mm<400, and 319 (75%) patients had those of maxLCBI4mm≥400. The maxLCBI4mm<400 group had a younger median age at onset (68years [IQR: 57–78years] vs. 73years [IQR: 64–80years], P=0.007), less frequent multi-vessel disease (39% vs. 51%, P=0.029), less frequent TIMI flow grade 0 or 1 before PCI (62% vs. 75%, P=0.007), and less frequent no-reflow immediately after PCI (5% vs. 11%, P=0.039). During a median follow-up period of 31 months [IQR: 19–48 months], the frequency of MACE was significantly lower in the maxLCBI4mm<400 group compared with the maxLCBI4mm≥400 group (4.7% vs. 17.2%, P=0.001). MaxLCBI4mm<400 was an independent predictor of absence of MACE at multivariable analysis (hazard ratio: 0.30 [confidence interval: 0.11-0.82], P=0.018).
Conclusion. MaxLCBI4mm<400 measured by NIRS in the infract-related lesions before PCI was associated with better long-term clinical outcomes in AMI patients.
CyberSecurity for Autonomous Vehicles Against Malware Attacks in Smart-Cities
Authors: Aurangzeb Sana , Aleem Muhammad , Khan Muhammad Taimoor , Anwar Haris , Siddique Muhammad Shaoor 
Published: November 2022

Abstract

Smart autonomous vehicles (AVs) are networks of cyber physical systems (CPS) in which they wirelessly communicate with other CPS sub-systems (e.g., smart -vehicles and smart-devices) to efficiently and securely plan safe travel. Due to unreliable wireless communication among them, such vehicles are an easy target of malware attacks that may compromise vehicles’ autonomy, increase inter-vehicle communication latency, and drain vehicles’ power. Such compromises may result in traffic congestion, threaten the safety of passengers, and can result in financial loss. Therefore, real-time detection of such attacks is key to the safe smart transportation and Intelligent Transport Systems (ITS). Current approaches either employ static analysis or dynamic analysis techniques to detect such attacks. However, these approaches may not detect malware in real-time because of zero-day attacks and huge computational resources. Therefore, we introduce a hybrid approach that combines the strength of both analyses to efficiently detect malware for the privacy of smart-cities.
Flow Characteristics of River Channels under Different Types of Ice Cover
Authors: Chengguang Li , Zhiwei Li , Xuequn Chen , Junfeng Liu 
Published: November 2022

Abstract
A RSM numerical model together with a laboratory measurement with Micro ADV were adopted to investigate flow through a straight rectangular flume under four conditions: no ice cover, continuous ice cover, discontinuous ice cover and inshore ice cover. Under the combined action of ice cover roughness and bed roughness, the flow structure is complex. The water depth with ice sheet conditions is generally larger than that without ice cover. The presence of ice cover makes the vertical profile no longer satisfies the classical logarithmic distribution. The stream-wise velocity increases gradually from the bottom of the riverbed and reaches its maximum at a point between the ice sheet and the riverbed, which is called the inflection point. After passing the inflection point of flow velocity, the flow velocity gradually decreases, eventually decreasing to 0 at the ice sheet. There is a large velocity gradient at the interface between the ice cover and the current. Comparison between the numerical prediction and laboratory measurement shows that the RSM model can well predict the flow structure of ice cover. Furthermore, the turbulent kinetic energy and dissipation rate are analyzed based on the RSM prediction. The increasing of turbulent kinetic energy and dissipation rate at the interface between ice cover and water surface indicates that ice cover causes more intense internal mixing and energy dissipation of water flow.
Preliminary assessment of the degree of food addiction through the Spanish Yale Food Addiction Scale for Children (S-YFAS-C) in a pilot pediatric population.
Authors: Brito Nestor Benitez , González Himar Pacheco , Robayna Berta Pinto , Redondo Fran Moreno , Romero Carlos Díaz , Fariña Yolanda Ramallo 
Published: November 2022

Abstract

Introduction.
The Spanish Yale Food Addiction Scale for Children (S-YFAS-C) scale is the first tool adapted to Spanish to evaluate food addiction (FA) in the paediatric population. The aim of this study is to preliminarily evaluate the degree of FA in a non-clinical pilot paediatric population.
Material and methods.
A transversal observational study was performed on a convenience sample comprised of boys and girls aged 9 to 12 (4th to 6th year primary school). The main outcome measures were evaluation of FA (S-YFAS-C scale), child feeding attitudes (ChEAT scale) and evaluation of body image (CDRS scale). Moreover, sociodemographic and anthropometric data were collected. A descriptive and bivariate analysis of the main characteristics of subjects and outcome measures was performed.
Results.
A total of 21 boys and 24 girls were preliminarily evaluated and the minimum and maximum values obtained were for age (9.48 – 12.33), weight in kilograms (26.6 – 64.5), height in centimetres (131-163), BMI (14.2-27.9) and BMI Z-score (-1.36 – 2.66). The average number of FA symptoms measured with the S-YFAS-C scale is 1.67±1.45 (range 0 - 7). A total of 20% of the sample shows three or more symptoms for FA, risk of developing a food disorder and distortion of the body image. Moreover, statistically significant differences were observed between desired body image in boys and girls (P=0.001).
Conclusions.
The S-YFAS-C scale enables evaluating food addiction in Spanish-speaking boys and girls. The data obtained in regard to quantifying symptoms are similar compared to the original scale (S-YFAS-C: 1.67±1.45 vs. YFAS-C: 2±1.81). The option to score the counting of symptoms is the most sensitive measure to evaluate subclinical food behaviours.
Community of Inquiry, Self-Efficacy, and Student Attitudes in Sustained Remote Health Professions Learning Environments
Authors: Burbage Amanda K. , Jia Yuane , Hoang Thuha 
Published: November 2022

Abstract
The purpose of this study was to investigate the impact of Community of Inquiry (CoI) presence types and self-efficacy on perceived student attitudes within a sustained remote learning environment. As institutions must remain ready for modality-altering situations, a better understanding of CoI and self-efficacy in sustained remote teaching and learning environments may help address gaps in current practices and perceived student attitudes. An interinstitutional team of health professions education researchers from six U.S. universities collected survey data from 205 health professions students representing a wide range of professions in five U.S. institutions. Latent mediation models under structural equation modeling framework were used to examine whether student self-efficacy mediates the relationship between CoI presence and student’s favorability of sustained remote learning delivered in the prolonged stages of the COVID-19 pandemic. Results showed that higher levels of teaching presence and social presence in the remote learning environment were associated with higher levels of remote learning self-efficacy which, in turn, predicts variance in positive attitudes toward remote learning. Only direct effects for cognitive presence and self-efficacy on the favorability of sustained remote learning were observed. CoI presence types explained 61%, 64%, and 88% of the variance respectively in student’s favorability of sustained remote learning. Theoretical implications of this study include the establishment of the CoI and its three presence types as a relevant and stable framework for investigating sustained remote health professions teaching and learning environments, not only carefully designed online learning environments.
Assessment on solubility and solid phase chemical fractionation of manganese in hot infusions of green and roasted mate
Authors: Leoncio Mariana Silva , Garcia Edivaldo Egea 
Published: November 2022

Abstract
A solid phase chemical fractionation (SPCF) of the Mn in hot infusions prepared from commercial samples of roasted (RM) and green mate (GM) using a chelating resin Chelex 100 (NH4+ form) was performed to assess the relative lability of this essential trace element (ETE). In addition, total Mn contents in the RM and GM samples and their infusions were determined by flame atomic absorption spectrometry. Furthermore, total polyphenol (TP) contents and the presencde of soluble melanoidins (SM) were correlated with the Mn solubility in the RM and GM infusions. From the SPCF study, it was possible to observe that the soluble Mn forms in the mate infusions were essentially associated to relatively noninert chemical species (98.4-99.7%), suggesting that they may be potentially bioavailable. In addition, the soluble Mn contents in the GM infusions were 20.5% higher than those found in the RM. Furthermore, Mn solubility in the (RM) infusions was highly and directly correlated (r = 0.99) with the soluble TP, while in the GM infusions it was high and inversely correlated with soluble TP (r = -0.87). On the other hand, Mn solubility in the RM and GM infusions were weakly correlated with the SM. It should be stressed GM infusions can contribute with 56.7% and 44.4% more than the RM infusions to the recommended adequate intake of Mn established for females and males, respectively. Moreover, this work is the first to evaluate and compare the relative lability of Mn and its solubility in the RM and GM infusions.
Integrated modeling to implicate evolving neoantigen-T cell interplays and immunotherapy efficacy in tumors
Authors: Ruihan Ruihan , Chyr Jacqueline , Wen Jianguo , Wang Yanfei , Zhao Weiling , Zhou Xiaobo 
Published: November 2022

Abstract
Immunotherapies have revolutionized cancer treatment modalities; however, predicting clinical response accurately and reliably remains challenging. Neoantigen load is considered as a fundamental genetic determinant of therapeutic response. However, only a few predicted neoantigens are highly immunogenetic, with little focus on intratumor heterogeneity (ITH) in the neoantigen landscape and its link with different features in the tumor microenvironment. To address this issue, we comprehensively characterized neoantigens arising from nonsynonymous mutations and gene fusions in lung cancer and melanoma. We developed a composite NEO2IS to characterize interplays between cancer and CD8 + T-cell populations. NEO2IS improved prediction accuracy of patient responses to immune-checkpoint blockades (ICBs). We found that TCR repertoire diversity was consistent with the neoantigen heterogeneity under evolutionary selections. Our defined neoantigen ITH score (NEOITHS) reflected infiltration degree of CD8 + T lymphocytes with different differentiation states and manifested the impact of negative selection pressure on CD8 + T-cell lineage heterogeneity or tumor ecosystem plasticity. We classified tumors into distinct immune subtypes and examined how neoantigen-T cells interactions affected disease progression and treatment response. Overall, our integrated framework helps profile neoantigen patterns that elicit T-cell immunoreactivity, enhance the understanding of evolving tumor-immune interplays and improve prediction of ICBs efficacy.
Postoperative fever is associated with infections in elderly patients aged 80 years or older after femoral intertrochanteric fracture surgeries
Authors: Leng Junsheng , Chang Xiao , Bai Qiushi , Fan Yu , Zou Xiongfei , Zhang Baozhong 
Published: November 2022

Abstract
Background
Postoperative fever (POF) following orthopedic surgeries was generally secondary to inflammatory responses and most diagnostic tests were unnecessary according to previous reports. To our knowledge, there has been no literature discussing POF in elderly patients after femoral intertrochanteric fracture (ITF) surgeries. This study aimed to investigate the incidence of POF and the association between POF and infections in patients aged 80 years or older after ITF surgeries.
Methods
We retrospectively reviewed 128 patients aged 80 years or older after ITF surgeries. A postoperative body temperature ≥ 38ºC was defined as POF. Diagnostic tests conducted for POF were reviewed. Univariate analysis was used to compare the variables. Logistic regression was used to identify the independent risk factor of infections.
Results
32 (25%) patients developed POF. Positive results were identified in 48.9% (22/45) of diagnostic tests. The positive rates of diagnostic tests were as follows: sputum cultures, 77.8% (7/9); urine cultures, 75% (3/4); urinalyses, 58.3% (7/12); chest radiographs, 36.4% (4/11); blood culture, 11.1% (1/9). The infection rate of the febrile patients was significantly higher than the afebrile patients (40.6% versus 17.7%, p = 0.008). After adjustment for age, sex and body mass index, POF was independently associated with infections (odds ratio = 3.4, 95% confidence interval = 1.4–8.1). In the febrile patients, the infection rate of patients who developed POF at postoperative day (POD) 2 or later was significantly higher than patients who developed POF within POD 1 (75.0% versus 29.2%, p = 0.022).
Conclusions
POF in patients aged 80 years or older following ITF surgeries was associated with postoperative infections. Diagnostic tests for respiratory and urinary systems were recommended for POF. POF occurred at POD 2 or later suggested increased infection risk in the febrile patients.
Nonclinical In Vitro Safety Assesment Summary of Hemp Derived (R/S)-Hexahydrocannabinol ((R/S)-HHC)
Authors: Collins Arianna C. , Tesfatsion Tesfay T. , Ramirez Giovanni A. , Ray Kyle P. , Cruces Westley 
Published: November 2022

Abstract
In pursuit of a more detailed understanding of the naturally rare occurring cannabinoid analogue, Hexahydrocannabinol (HHC), safety becomes a question when possible human consumption is introduced. We explore the safety profile of HHC, using a third-party lab to produce preclinical in vitro safety profile data on the cyto-toxicity of cardiomyocytes through hERG, hepatocytes, and lung fibroblasts. hERG1 (The human Ether Related Gene) is a gene that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (simply denoted as “hERG”) is best known for its contribution to the electrical activity of the heart: the hERG channel mediates the repolarizing current in the cardiac action potential, which helps coordinate the heart's beating. Preceding studies of HHC, neglect the base scaffold structure of HHC2, and test on synthetic derivatives, and various analogs. The purpose of these studies is to demonstrate HHC as a safe cannabinoid for potential human consumption. The preclinical assessments of HHC did not indicate any cardiac safety issues via data from a hERG3 fast patch assay. HHC also demonstrated no cytotoxicity in the plated human liver hepatocyte cell viability assay. HHC, according to in vitro data produced potential cytotoxic effects in human lung fibroblasts when exceeding 10 mM concentrations, when reviewing the data, safe possible human consumption is feasible without complications.
Compound Dihuang Granule Changes Gut Microbiota of MPTP-Induced Parkinson's Disease Mice via Inhibiting TLR4/NF-κB Signaling
Authors: He Zhu-qing , Huan Peng-fei , Wang Li , He Jian-cheng 
Published: November 2022

Abstract
Intestinal flora was connected to Parkinson's Disease (PD) pathology. The ancient Chinese medication for PD is Compound Dihuang Granule (CDG), and we found a neuroprotective function in treating the constipation of PD patients. Nevertheless, the mechanism of action still needs to be clarified. We predicted the probable targets of CDG against PD through Traditional Chinese medicine (TCM) network pharmacology and verified the analysis through animal experiments in vivo. The protein-protein interaction (PPI) network analysis screened PD-related genes, including TLR4, TBK1, NF-KB (NF-KB p65), and TNF(TNF-α). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses proved that the NF-κB and toll-like receptor signaling pathways serve a key function in CDG therapy of PD. Molecular docking analysis demonstrated that CDG strongly connected to TLR4/NF-κB. Experiments findings indicated that CDG improved the damage of DA neurons and gut microbial dysbiosis, ameliorated motor impairments, and suppressed the PD-associated inflammation and oxidative stress in mice induced by MPTP. CDG suppressed the inflammatory proteins in the colon and protected the intestinal barrier. Overall, CDG improved gut microbial in PD by blocking the pathway of TLR4/NF-κB.