bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building social identity-based groups to enhance online peer support for patients with chronic disease: a pilot study using mixed-methods evaluation
Authors: Su Jingyuan , Dugas Michelle , Guo Xitong , Gao Guodong 
Published: March 2022

AbstractOnline peer support is increasingly important to encourage patients with chronic diseases to engage in successful self-management. However, studies mainly focus on individual-level participation and have not fully explored how to maximize the impact of online peer support through group identification. In this study, we aim to build an online social identity-based group to examine the impact of group identity on peer support. Twenty-five participants who completed the first phase of a larger study were randomly assigned either to the treatment group (identity-based group level, n = 15, three subgroups, five members in each subgroup) or to the control group (individual-level, n = 10). All participants in both treatment and control groups received the same tasks and incentives. Peer support behavior (informational support and emotional support), task completion (knowledge learning, self-tracking behavior), and health-related outcomes (self-efficacy [SE] and HbA1c) were collected for qualitative and quantitative analysis. Results from a 3-month pilot experiment showed that the treatment group offered substantial enhancement in peer support compared to the control group. It also significantly promoted improvement in SE. However, there was no significant difference in task completion or changes in HbA1c between the two groups. The results of the content analysis suggest that having a team leader, timely responsiveness, and intergroup competition played important roles in building social identity-based online groups and subsequently generating peer support. We provide some encouraging results that indicate how online groups may be effectively designed to promote peer support.
A Lay Theory Perspective on Age-Based Stereotyping
Authors: Keating Lauren A , Heslin Peter A 
Published: March 2022

Abstract
In their insightful commentary, Murphy and DeNisi (2021) highlight that there is little consistent evidence for the proposition that age stereotypes negatively influence personnel decisions about older employees. Yet older workers increasingly report witnessing or experiencing age discrimination based on such stereotypes that impede them from securing and maintaining employment, as well as being given developmental opportunities and advancing at work. What, then, might explain this discrepancy between the scientific and anecdotal evidence? In response to Murphy and DeNisi’s (2021) call to consider potential moderators of stereotyping effects, we introduce lay theories that managers hold about older employees as a step toward understanding when and why age-stereotyping and ageist personnel management may be likely to emerge. We also discuss how older employees’ meta-lay theories could shape their reactions to Murphy and DeNisi’s (2021, p. 5) potentially dissonant message that research does not support the widely held assumption that “negative stereotypes of older workers play an important role in age discrimination in the workplace.” We suggest several avenues for research focused on understanding lay theory and age-stereotyping dynamics, as well as how this research could be leveraged for practical initiatives to ameliorate their potentially destructive impact.
First molecular phylogeny and species delimitation of West PalaearcticPollenia(Diptera: Polleniidae)
Authors: Szpila Krzysztof , Piwczyński Marcin , Glinkowski Wojciech , Lutz Lena , Akbarzadeh Kamran , Baz Arturo , Johnston Nikolas P , Grzywacz Andrzej 
Published: March 2022

AbstractCluster flies of the genus Pollenia are known as mass invaders of human dwellings, but are important plant pollinators in the temperate climatic zone. Despite being the most species-rich and widespread genus in Polleniidae, no study to date has tested infrageneric relationships using molecular data. Here we use three molecular markers, COI, Ef-1α and CAD to reconstruct the phylogenetic relationships between 18 West Palaearctic species of Pollenia, representing eight predefined morphological species groups, using both maximum likelihood and Bayesian approaches. We show several instances where morphological and molecular results are congruent, but also instances where they are discordant. We develop a COI barcode reference library for 18 species, containing newly generated data (87 sequences) and sequences retrieved from the Barcode of Life Data System (BOLD). We analyse this dataset using both Automatic Barcode Gap Discovery (ABGD) and Bayesian Phylogenetics & Phylogeography (BPP) methods to validate morphological species hypotheses and delimit species. The results of these species delimitation analyses were, in most cases, identical and aligned with predefined morphological species concepts. Based on the results of our analyses, we synonymize P. moravica (stat. rev.) with P. amentaria and assign 191 unidentified sequences from BOLD to named morphospecies.
Varicella Zoster With Pemphigus-like Reaction
Authors: Fernandez-Flores Angel , Cassarino David 
Published: March 2022

Abstract:
We present a case of a 55-year-old man with a rash on his right foot that was biopsied and diagnosed as a Varicella Zoster virus infection with an accompanying positive immunohistochemical study with antiviral antibodies. He concomitantly suffered from a Varicella Zoster virus meningitis. The skin biopsies not only showed clear histologic signs of viral cytopathic effects but also showed intercellular IgG and C3 intraepidermal staining by direct immunofluorescence study, findings which are typically consistent with pemphigus vulgaris. However, the patient did not have any history of pemphigus; there was no mucosal involvement, and serum antibodies to desmoglein 1 and 3 were negative. After discharge, the patient continued to have right-sided foot pain, and he continued the acyclovir treatment.
Presence of Skin Tissue-Resident Memory T Cells in Human Nonmalignant and Premalignant Melanocytic Skin Lesions and in Melanoma
Authors: Willemsen Marcella , Tio Darryl , Krebbers Gabrielle , Kasiem Fazira R. , Jaspars Elisabeth H. , Matos Tiago R. , Bekkenk Marcel W. , Bakker Walbert J. , Luiten Rosalie M. 
Published: March 2022

Abstract:
The infiltration of tissue-resident memory (TRM) cells in melanoma correlates with improved survival, suggesting an important role for TRM cells in immunity against melanoma. However, little is known about the presence of TRM cells in nonmalignant and premalignant melanocytic lesions. This study aimed to evaluate the presence of TRM cells in human skin melanocytic lesions, representing the spectrum from healthy skin to metastatic melanoma. FFPE sections from healthy skin, sun-exposed skin, benign nevi, lentigo maligna (LM), primary LM melanoma, and primary cutaneous and metastatic melanoma were analyzed by immunohistochemistry. The number of infiltrating cells expressing TRM-associated markers, CD3, CD4, CD8, CD69, CD103, and CD49a, was quantified by digital analyses. Multiplex immunofluorescence was performed to analyze coexpression of TRM cell markers. More T cells and CD69+ cells were found in melanoma lesions, as compared with healthy skin and nevi. CD103+ and CD49a+ cell numbers did not significantly differ. More importantly, no differences were seen in expression of all markers between healthy skin and benign nevi. Similar results, except for CD69, were observed in LM melanoma, as compared with LM and sun-exposed skin. Interestingly, multiplex immunofluorescence showed that nevi tissues have comparable CD103+ T cell numbers with healthy skin but comprise more CD103+ CD8+ cells. Expression of TRM cell markers is significantly increased in melanoma, as compared with nonmalignant skin. Our data also show that TRM cells are not abundantly present already in premalignant tissues. Further studies on the specificity of TRM cells for melanocyte/melanoma antigens may reveal their significance in cancer immunosurveillance.
Buttocks' Skin Laxity Severity Scale
Authors: Hexsel Doris , Valente-Bezerra Indira , Dal'Forno Taciana , Camozzato Fernanda , Mosena Gabriela , Parizotto Joanna Tereza , Soirefmann Mariana , Ughini Marilene , Carvalho de Matos Rosa Maria , Silva Aline Flor , Siega Carolina 
Published: March 2022

BACKGROUND
Clinical scales are useful to assess skin laxity in different areas of the body.

OBJECTIVE
To elaborate and validate a photonumeric scale to assess buttocks skin laxity.

MATERIALS AND METHODS
The Buttocks' Skin Laxity Severity Scale (SLSS) was developed based on a sample of 120 patients. The SLSS validity and reliability were assessed in 2 validation cycles, performed by 8 dermatologists assessing 50 clinical cases. Both criteria and construct validity were tested.

RESULTS
The Buttocks' SLSS is composed by 5 clinical aspects of skin laxity graded from absent (0) to severe (3): buttocks ptosis, skin scalloped appearance, infragluteal fold, localized fat on the lower third of the buttocks, and linear depressed lesions. Final skin laxity classification results from the sum of each item grade multiplied by its weight and varies from 0 to 24. Overall, Kendall, weighted kappa, and intraclass correlation coefficients indicated very good reliability and consistent interrater and intrarater agreement (p < .001). Cronbach alpha of 0.82 indicates high scale reliability. The scale validity was confirmed by criteria validity tests (rs: 0.72, p < .05).

CONCLUSION
Buttocks' SLSS is a reliable and valid scale to identify skin laxity severity and its different features, and it is an accurate tool for clinical research.
Long term efficacy and safety profiles of iris-fixated foldable anterior chamber phakic intraocular lens implantation in eyes with ≥ 10-year follow-up
Authors: Papa-Vettorazzi Mario R. , Moura-Coelho Nuno , Manero Felicidad , Cruz-Rodriguez José B. , Elies Daniel , Güell José L. 
Published: March 2022

Abstract

Purpose:
Evaluate the long-term efficacy, safety, predictability, and stability of a foldable anterior chamber phakic intraocular lens (Artiflex) in eyes with ≥10-year follow-up.

Setting:
Instituto de Microcirugía Ocular, Barcelona, Spain.

Design:
Retrospective study.

Methods:
Eyes undergoing Artiflex implantation from 2008-2011 with ≥10-year follow-up were included. Variables analyzed were: preoperative, 1-month, 1-year, 5-years, and last follow-up uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction, spherical equivalent (SE), endothelial cell count (ECC), and intraocular pressure (IOP). Descriptive statistics were performed and results reported following the Standard for Reporting Refractive Surgery Outcomes.

Results:
76 eyes (40 patients) were analyzed, mean follow-up 10.67 ± 0.64 years. Mean preoperative SE was -8.26 ± 2.47D and mean preoperative cylinder -0.95 ± 0.86D. At last follow-up, efficacy and safety indices were 0.82 and 1.11, respectively. In total, 58 (76%) eyes achieved an UDVA of ≥20/40. 30 (39%) eyes gained ≥1 line of CDVA, and no eye lost ≥2 lines of CDVA. At final follow-up, 46 (61%) and 58 (76%) eyes were within ±0.50D and ±1.00D of attempted SE correction, respectively. 72 (95%) eyes had ≤1.00D of postoperative astigmatism and 46 (61%) eyes were within ±15° from the intended correction axis. At the last visit, a statistically significant myopic progression of -0.56 ± 0.83D was observed (p=0.01). Mean ECC loss at last follow-up was 12.2 ± 12.5%. IOP remained stable. 2 eyes (2.63%) developed cataract after 10.3 years.

Conclusions:
Long-term results demonstrate that Artiflex is effective, predictable, stable, and safe.
Molecular Characterization and Detection of Macrolide and Fluoroquinolone Resistance Determinants in Mycoplasma genitalium in South Africa, 2015 to 2018
Authors: Mahlangu Mahlape P. , Müller Etienne E. , Da Costa Dias Bianca , Venter Johanna M.E. , Kularatne Ranmini S. 
Published: March 2022

Background
Antimicrobial resistance in Mycoplasma genitalium is a global concern, as therapeutic options are limited. We aimed to determine the prevalence of macrolide and fluoroquinolone resistance–associated genetic determinants and strain diversity in M. genitalium–positive surveillance specimens from symptomatic primary health care center attendees in South Africa (2015–2018). A secondary objective was to investigate for an association between M. genitalium strain type, HIV serostatus, and antimicrobial resistance.

Methods
A total of 196 M. genitalium–positive specimens from adult males and females presenting with genital discharge to primary health care centers were tested for resistance-associated mutations in 23S rRNA, parC and gyrA. A dual-locus sequence type (DLST) was assigned to M. genitalium strains based on the detection of single nucleotide polymorphisms in the semiconserved 5′ region of the mgpB gene (MG191-sequence typing) as well as the enumeration of short tandem repeats within the lipoprotein gene (MG309 short tandem repeat typing).

Results
The A2059G mutation in 23S rRNA, associated with macrolide resistance, was detected in 3 of 182 specimens (1.7%; 95% confidence interval, 0.3–4.7). We did not detect gyrA or parC mutations associated with fluoroquinolone resistance in specimens that could be sequenced. Molecular typing with DLST revealed genetic heterogeneity, with DLST 4–11 being the most common M. genitalium strain type detected. There were no associations between DLST and macrolide resistance or HIV infection.

Conclusions
We found a low prevalence of M. genitalium strains with macrolide resistance–associated mutations over a 4-year surveillance period. Ongoing antimicrobial resistance surveillance is essential for informing genital discharge syndromic treatment guidelines.
Virtual Surgical Subinternships: Course Objectives and a Proposed Curriculum
Authors: Reghunathan Meera , Dean Riley A. , Hauch Adam , Reid Christopher M. , Gosman Amanda A. , Lance Samuel H. 
Published: March 2022

Background:
Due to the recent COVID-19 pandemic, patient care and medical education have faced many significant changes. The Association of American Medical Colleges and the American Council of Academic Plastic Surgery officially recommended halting all student rotations and interviews for the year. This change has unfortunately fallen squarely at the onset of a vital season for education and recruitment of plastic surgery subinterns. This article presents a curriculum for a single institution’s virtual surgical subinternship to help inspire ideas and inspiration for programs developing their own virtual subinternships.

Methods:
The goals for the virtual surgical subinternship are focused on student preparation for residency and remain similar to those outlined by the core competencies for in-person rotations. The first virtual subinternship in plastic surgery modeled after the curriculum presented was offered as a 2-week course starting May of 2020.

Results:
The components of the curriculum include a self-study syllabus, virtual case reviews, virtual suture laboratory, educational teleconferences, participation in research, and mentorship meetings. The 2-week course has approximately 25 hours of conferences and teaching, involving direct interaction with residents and faculty, and approximately 15 hours of self-directed learning.

Conclusions:
To the authors’ knowledge, this was the first virtual subinternship offered for rising fourth-year medical students. They strongly encourage other residency training programs to offer similar virtual learning opportunities for medical students, particularly for those without access to a home plastic surgery training program. The curriculum presented in this article is simply to provide ideas, inspiration, and a potential framework for programs wishing to create similar virtual learning opportunities.
Objective Comparison of Donor-Site Morbidity following Full and Thoracodorsal Nerve-Preserving Split Latissimus Dorsi Flaps
Authors: Oberhofer Haley M. , Samant Sonja S. , Swan Courtney C. , Wolfe Erin M. , Satteson Ellen S. , Leyngold Mark M. , Chim Harvey 
Published: March 2022

Background:
The latissimus dorsi flap is a workhorse for reconstruction. However, flap harvest has been variably reported to result in donor-site morbidity. The aim of this study was to compare donor-site morbidity following harvest of a split latissimus dorsi flap, preserving the anterior branch of the thoracodorsal nerve, and a traditional nerve-sacrificing full latissimus dorsi flap.

Methods:
Patients who underwent split or full latissimus dorsi flaps between July of 2017 and August of 2020 at a single center were recalled for assessment. Donor-site morbidity in the shoulder was evaluated through the Disabilities of the Arm, Shoulder and Hand questionnaire; the Shoulder Pain and Disability Index; and the American Shoulder and Elbow Surgeons questionnaire. Medical Research Council strength grading was also performed.

Results:
A total of 22 patients in the split latissimus dorsi cohort and 22 patients in the full latissimus dorsi cohort were recalled. Patient-reported outcomes as assessed through the Disabilities of the Arm, Shoulder and Hand questionnaire; Shoulder Pain and Disability Index; and American Shoulder and Elbow Surgeons questionnaire scores revealed statistically greater (p < 0.05) donor-site morbidity associated with the traditional compared to split latissimus dorsi flap. Seven patients in the full latissimus dorsi cohort had less than Medical Research Council grade 5 power at the shoulder, whereas all patients in the split latissimus dorsi cohort demonstrated full power at the shoulder.

Conclusions:
Traditional full latissimus dorsi flaps were found to result in greater donor-site morbidity compared to thoracodorsal nerve-preserving split latissimus dorsi flaps. Split latissimus dorsi flaps may be beneficial in preserving donor-site function and strength.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.
Closed-Incision Negative-Pressure Wound Therapy after Resection of Soft-Tissue Tumors Reduces Wound Complications: Results of a Randomized Trial
Authors: Dadras Mehran , Ufton Dominic , Sogorski Alexander , Wallner Christoph , Wagner Johannes M. , Lehnhardt Marcus , Harati Kamran , Behr Björn 
Published: March 2022

Background:
Wound healing after resection of large soft-tissue tumors is often impaired by large dead space and fluid collection. Recently, the authors were able to show an association of wound complications with worse oncologic outcome in soft-tissue sarcomas. The aim of the study was to examine the value of closed-incision negative pressure wound therapy on postoperative wound drainage and wound complications after soft-tissue tumor resection.

Methods:
Patients for whom resection is planned of a soft-tissue tumor larger than 10 cm in diameter of the extremities or the trunk were allocated randomly to one of two groups. After wound closure, patients in the study group received closed-incision negative-pressure wound therapy for a duration of 5 days, whereas those in the control group received regular dressings. The amount of drainage fluid, course of wound healing, length of hospital stay, and wound edge perfusion at postoperative day 5 measured by white-light infrared spectroscopy were compared.

Results:
Sixty patients could be included in the study with even distribution to both study arms, meeting the goal. The postoperative course of wound drainage volume was significantly lower in the study group, and hospital stay was significantly shorter, with 9.1 ± 3.8 days versus 13.9 ± 11.8 days. The occurrence of wound complications was significantly lower in the study group on time-to-event analysis (one versus six). Tissue spectroscopy revealed a significantly higher oxygen saturation increase in the wound edge for the study group versus the control group.

Conclusion:
Closed-incision negative-pressure wound therapy should be considered for patients undergoing resection of large soft-tissue tumors.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, II.
The Multiple-U Technique: A Novel Microvascular Anastomosis Technique That Guarantees Everted Anastomosis Sites with Solid Intima-to-Intima Contact
Authors: Kuo Spencer Chia-Hao , Tsai Yueh-Ju , Kuo Pao-Jen , Huang Faye , Lin Tsan-Shiun , Hsieh Ching-Hua 
Published: March 2022

Summary:The key to successful microvascular anastomosis is achieving intima-to-intima contact, which is not always easy. In this article, the authors propose the multiple-U technique, which is a novel microvascular anastomosis technique that characterizes easy and reliable intima-to-intima contact. The technique was performed on patients who underwent free flap reconstruction for head and neck defects at the Kaohsiung Chang Gung Memorial Hospital from September 1, 2020, to November 30, 2020. The immediate patency test results for all vessel anastomoses were positive, and the postoperative recovery courses of the patients were without any vascular complications. In conclusion, the multiple-U technique is a widely available technique that guarantees everted anastomosis sites and solid intima-to-intima contact. This technique can be performed on both arterial and venous anastomoses regardless of vessel size and wall thickness.
Sharing the Operating Room: A Descriptive Study of Combined and Collaborative Plastic Surgery Cases
Authors: Davis Matthew J. , Lopez Joseph P. , Turner Acara , Abu-Ghname Amjed , Davies Lesley W. , Buchanan Edward P. 
Published: March 2022

Background:
Plastic surgeons are often asked for intraoperative assistance by other surgical services. Improvement of a plastic surgery service has been shown to improve patient outcomes, decrease length of stay, and increase hospital revenue, yet plastic surgery’s contribution to a hospital tends to be undervalued. The purpose of this study was to quantify the multidisciplinary role the plastic surgery service plays within a single, large pediatric institution.

Methods:
Surgical cases involving both plastic surgery and at least one other team were identified from 2016 to 2019. Each case was categorized as either “combined” or “collaborative” based on whether the two teams worked separately on separate problems or together on the same problem, respectively. Data points collected included combined and collaborative cases, operating room hours, and total hospital charges billed.

Results:
Of the 7564 total plastic surgery cases performed, multidisciplinary cases made up a minority of total cases (16 percent) but required 32 percent of the operating room hours and provided 49 percent of the total charges billed. Collaborative cases alone accounted for 20 percent of the service’s operating room hours and 39 percent of total charges billed, while making up only 8 percent of total cases.

Conclusions:
Relative to cases where plastic surgery operates alone, combined and collaborative cases account for a disproportionately high number of operating room hours and provide a disproportionately high amount of charges billed.
Sublingual Gland Observed on Salivary Gland Scan
Authors: Jung Ju-Yang , Yoon Joon-Kee , Lee Su Jin , An Young-Sil 
Published: March 2022

Abstract
The major salivary glands, namely, the parotid, submandibular, and sublingual glands, are important in maintaining oral cavity health. A salivary gland scan is used to evaluate the uptake and excretory function of the salivary glands. By intravenously injecting 99mTcO4
−, which is distributed like chloride ions in the body, the glands become visible on the salivary gland scan. The parotid and submandibular glands are typically appreciated on the salivary gland scan, but the sublingual gland is not. We present a rare image of a prominent sublingual gland on a salivary gland scan.