bluuebunny/crossref_metadata_2025_split huggingface dataset:
An overview of preventive and control strategies for common mental health disorders during infectious disease epidemics
Authors: Parsekar Shradha , Dhyani Vijay Shree , Rajwar Eti , Krishnan Jisha B , Venkatesh Bhumika Tumkur , Saravu Kavitha , Brand Helmut 
Published: March 2022

Background: The emergence of the COVID-19 pandemic has affected people’s mental health owing to different factors. The primary objective of this review was to systematically summarize available literature on the range of interventions for common mental health disorders during an infectious disease outbreak, specifically focusing on the COVID-19 pandemic. Methods: We searched PubMed, PsychInfo, Scopus, Web of Science, CINAHL, EPPI mapper and Google Scholar to identify English literature published since January 2010. We included scientific research studies and grey literature, extracted the information and summarized results thematically. Results: A range of common mental health disorders that affected populations from most parts of the world and associated factors were identified. We thematically classified intervention into the following: providing accurate and timely information and ensuring adequate supplies of daily need essentials; developing mindfulness and resilience that can revive self-sufficiency and self-awareness in stress management; early identification; providing necessary mental health care through professionals; and health system strengthening and capacity building interventions. Conclusion: There is an immediate need for a collective action through inter-sectoral coordination at community, national and international levels. Policymakers and program implementers should be prepared to tackle common mental health disorders amidst the ongoing COVID–19 pandemic and in future emerging and re-emerging infectious disease outbreaks.
Human papillomavirus (HPV) detection in vaginal self-samples: evaluation of eNat® as an alternative suspension medium to ThinPrep®PreservCyt® for vaginal swabs
Authors: Giubbi Chiara , Martinelli Marianna , Vallini Ivan , Paganoni Silvia , Dafa'alla Tarig , Perdoni Federica , Musumeci Rosario , Wu Winnie , Castriciano Santina , Romano Paolo , Cocuzza Clementina E. 
Published: March 2022

Human Papillomavirus (HPV) testing on self-collected samples allows for improved coverage rates of cervical cancer (CC) screening programs. ThinPrep®PreservCyt® (HOLOGIC®, USA) medium is widely used for the suspension of cervical and vaginal self-samples. However, this medium is costly, toxic, and flammable, involving special handling procedures which make its use difficult in screening programs, particularly in low- and middle-income countries. This pilot study aimed to evaluate the analytical performance of eNat® (Copan SpA), an alternative non-alcohol-based suspension medium, compared to ThinPrep®PreservCyt® (HOLOGIC®) for high-risk HPV (hrHPV) detection in vaginal self-collected swabs using three different real-time polymerase chain reaction (RT-PCR) HPV assays: Anyplex™II HPV28 (Seegene, Korea), Papilloplex® High Risk HPV (GeneFirst, UK), and HPV OncoPredict (Hiantis, Italy). 30 women, referred to colposcopy, were enrolled in this observational, prospective pilot study and asked to collect two vaginal self-taken samples, which were suspended in 5 mL of ThinPrep®PreservCyt® or eNat®. Nucleic acids were extracted from 200 μL using Microlab Nimbus platform (Seegene, Korea) and tested with the three different RT-PCR full-genotyping high-risk HPV assays. The HPV results of vaginal samples resuspended in the two different media were compared to those obtained from the reference clinician-collected cervical sample from the same woman. hrHPV detection in vaginal self-samples suspended in both media demonstrated a substantial agreement with cervical samples with the three assays under-investigation (0.667<k<0.796). Moreover, the discordances between vaginal self-samples collected from the same woman were found only in cases of normal cytology or low-grade cytological lesions and were generally related to low hrHPV viral loads as indicated by the quantitative HPV OncoPredict assay (6.24E+02 copies/10,000 cells). This study demonstrated a very good agreement between cervical and vaginal self-collected samples suspended in ThinPrep®PreservCyt® and eNat®, suggesting that the latter could represent a good alternative medium in HPV screening programs based on self-collection.
Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS Foundation Trust
Authors: Colton Hayley , Hodgson David , Hornsby Hailey , Brown Rebecca , Mckenzie Joanne , Bradley Kirsty L. , James Cameron , Lindsey Benjamin B. , Birch Sarah , Marsh Louise , Wood Steven , Bayley Martin , Dickson Gary , James David C. , Nicklin Martin J. , Sayers Jon R. , Zafred Domen , Rowland-Jones Sarah L. , Kudesia Goura , Kucharski Adam ,   CMMID COVID-19 Working Group, Darton Thomas C. , de Silva Thushan I. , Collini Paul J. 
Published: March 2022

Background: We aimed to measure SARS-CoV-2 seroprevalence in a cohort of healthcare workers (HCWs) during the first UK wave of the COVID-19 pandemic, explore risk factors associated with infection, and investigate the impact of antibody titres on assay sensitivity. Methods: HCWs at Sheffield Teaching Hospitals NHS Foundation Trust were prospectively enrolled and sampled at two time points. We developed an in-house ELISA for testing participant serum for SARS-CoV-2 IgG and IgA reactivity against Spike and Nucleoprotein. Data were analysed using three statistical models: a seroprevalence model, an antibody kinetics model, and a heterogeneous sensitivity model. Results: Our in-house assay had a sensitivity of 99·47% and specificity of 99·56%. We found that 24·4% (n=311/1275) of HCWs were seropositive as of 12th June 2020. Of these, 39·2% (n=122/311) were asymptomatic. The highest adjusted seroprevalence was measured in HCWs on the Acute Medical Unit (41·1%, 95% CrI 30·0–52·9) and in Physiotherapists and Occupational Therapists (39·2%, 95% CrI 24·4–56·5). Older age groups showed overall higher median antibody titres. Further modelling suggests that, for a serological assay with an overall sensitivity of 80%, antibody titres may be markedly affected by differences in age, with sensitivity estimates of 89% in those over 60 years but 61% in those ≤30 years. Conclusions: HCWs in acute medical units and those working closely with COVID-19 patients were at highest risk of infection, though whether these are infections acquired from patients or other staff is unknown. Current serological assays may underestimate seroprevalence in younger age groups if validated using sera from older and/or more severe COVID-19 cases.
Demand Expansion and Cannibalization Effects from Retail Store Entry: A Structural Analysis of Multichannel Demand
Authors: Shriver Scott K. , Bollinger Bryan 
Published: March 2022

In this paper, we investigate the demand response of a firm’s existing customers to retail store entry and which aspects of the response are demand-expanding and which cannibalize online sales. The empirical goal of the paper is to separately identify the effects of customer-to-store distance on purchase frequency, channel choice, and expenditure per purchase, using transaction-level data from a multichannel apparel brand. Our identification strategy exploits within-customer variation in distance resulting from store entry during a period of rapid retail expansion. We establish retail distance effects using descriptive regressions before developing a unified structural model that affords rich counterfactual analyses and further controls for product category preferences. We find material effects of decreasing retail store distance on purchase frequency and retail channel choice but not expenditures per purchase. Our structural model ascribes mechanisms to these effects in the form of increased brand consideration, higher retail utility from nonmonetary factors (e.g., reduced driving times), and infungibility of monetary transportation costs with budgets for apparel. Our estimates imply that a 10% reduction in retail store distance increases retail channel expenditures by 1.9% and decreases online channel expenditures by 1.2%, resulting in a 0.4% increase in total expenditures. Through counterfactual experiments, we demonstrate that retail expansion can ultimately limit the ability of the firm to price discriminate across channels because reducing transportation costs weakens the firm’s ability to enforce channel-based segmentation schemes. This paper was accepted by Matthew Shum, marketing. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2022.4308 .
Assessment and examination of the cardiovascular system
Authors: Harcharran Maleka 
Published: March 2022

Cardiovascular disease is the leading cause of death in the UK. Maleka Harcharran describes a systematic overview of conducting a focused assessment and examination of the cardiovascular system The heart is the most vital organ in the body. Therefore, advanced practitioners must understand the basic anatomy and physiology related to the heart and how to conduct a thorough clinical assessment and examination of the cardiovascular system. This article will provide a systematic overview of conducting a focused assessment and examination of the cardiovascular system.
Benefits of quasi-continuous symbol rate tunability in links constrained by ROADM filtering
Authors: Searcy Steven , Richter Thomas , Burtsev Sergey , Tibuleac Sorin 
Published: March 2022

As modern optical networks continue evolving toward higher symbol rates while supporting tight channel spacing, penalties due to optical filtering incurred by transmission through reconfigurable optical add-drop multiplexers (ROADMs) can become significant within the overall link budget. For this reason, filtering impairments must be realistically assessed and accurately modeled, particularly in terrestrial networks where signals may traverse many ROADMs. Given that modern transceivers can provide flexible modulation options and most ROADMs in use today support flexible grid operation, there remains the challenge of optimizing performance and/or capacity while managing these multiple degrees of freedom. In this work, we use real-time transceivers with a tunable symbol rate up to 72 GBaud and variable modulation up to 64QAM to experimentally investigate the impact of ROADM filtering on the optimum operating condition required to maximize channel capacity or margin. We also present a simplified model for considering the filtering impairment as an additive noise term and use it to predict performance in other scenarios. It is shown that symbol rate tunability in steps below 5 GBd is required to maximize the margin for a given link passband. Finally, we explore the difference in performance for filtering conditions with passband narrowing on both sides of the signal, assuming individual wavelength routing, or only on one side of the signal, assuming multi-carrier routing.
Tunable microcavities coupled to rare-earth quantum emitters
Authors: Xia Kangwei , Sardi Fiammetta , Sauerzapf Colin , Kornher Thomas , Becker Hans-Werner , Kis Zsolt , Kovacs Laszlo , Dertli Denis , Foglszinger Jonas , Kolesov Roman , Wrachtrup Jörg 
Published: March 2022

Electro-optical control of on-chip photonic devices is an essential tool for efficient integrated photonics. Lithium niobate on insulator (LNOI) is an emerging platform for on-chip photonics due to its large electro-optic coefficient and high nonlinearity. Integrating quantum emitters into LNOI would extend their versatility in classic photonics to quantum computing and communication. Here, we incorporate rare-earth ion (REI) quantum emitters into electro-optical tunable lithium niobite (LN) thin films and demonstrate control of LN microcavities coupled to REIs over a frequency range of 160 GHz with 5 µs switching speed. Dynamic control of the cavities enables modulation of the Purcell enhancement of REIs with short time constants. Using Purcell enhancement, we show evidence of detecting single

Y

b

3
+

ions in LN cavities. Coupling quantum emitters in fast tunable photonic devices is an efficient method to shape the waveform of the emitter. It also offers a platform to encode quantum information in the integration of a spectral–temporal–spatial domain to achieve high levels of channel multiplexing, as well as an approach to generate deterministic single-photon sources.
Implementation of rapid and frequent SARS-CoV2 antigen testing and response in congregate homeless shelters
Authors: Aranda-Díaz Andrés , Imbert Elizabeth , Strieff Sarah , Graham-Squire Dave , Evans Jennifer L. , Moore Jamie , McFarland Willi , Fuchs Jonathan , Handley Margaret A. , Kushel Margot 
Published: March 2022

Background
People experiencing homelessness who live in congregate shelters are at high risk of SARS-CoV2 transmission and severe COVID-19. Current screening and response protocols using rRT-PCR in homeless shelters are expensive, require specialized staff and have delays in returning results and implementing responses.

Methods
We piloted a program to offer frequent, rapid antigen-based tests (BinaxNOW) to residents and staff of congregate-living shelters in San Francisco, California, from January 15th to February 19th, 2021. We used the Reach-Effectiveness-Adoption-Implementation-Maintenance (RE-AIM) framework to evaluate the implementation.

Results
Reach: We offered testing at ten of twelve eligible shelters. Shelter residents and staff had variable participation across shelters; approximately half of eligible individuals tested at least once; few tested consistently during the study.
Effectiveness: 2.2% of participants tested positive. We identified three outbreaks, but none exceeded 5 cases. All BinaxNOW-positive participants were isolated or left the shelters.
Adoption: We offered testing to all eligible participants within weeks of the project’s initiation.
Implementation: Adaptations made to increase reach and improve consistency were promptly implemented.
Maintenance: San Francisco Department of Public Health expanded and maintained testing with minimal support after the end of the pilot.

Conclusion
Rapid and frequent antigen testing for SARS-CoV2 in homeless shelters is a viable alternative to rRT-PCR testing that can lead to immediate isolation of infectious individuals. Using the RE-AIM framework, we evaluated and adapted interventions to enable the expansion and maintenance of protocols.
COVID-19 and social determinants of health: Medicaid managed care organizations’ experiences with addressing member social needs
Authors: Opoku Samuel T. , Apenteng Bettye A. , Kimsey Linda , Peden Angie , Owens Charles 
Published: March 2022

Background
The significant adverse social and economic impact of the COVID-19 pandemic has cast broader light on the importance of addressing social determinants of health (SDOH). Medicaid Managed Care Organizations (MMCOs) have increasingly taken on a leadership role in integrating medical and social services for Medicaid members. However, the experiences of MMCOs in addressing member social needs during the pandemic has not yet been examined.

Aim
The purpose of this study was to describe MMCOs’ experiences with addressing the social needs of Medicaid members during the COVID-19 pandemic.

Methods
The study was a qualitative study using data from 28 semi-structured interviews with representatives from 14 MMCOs, including state-specific markets of eight national and regional managed care organizations. Data were analyzed using thematic analysis.

Results
Four themes emerged: the impact of the pandemic, SDOH response efforts, an expanding definition of SDOH, and managed care beyond COVID-19. Specifically, participants discussed the impact of the pandemic on enrollees, communities, and healthcare delivery, and detailed their evolving efforts to address member nonmedical needs during the pandemic. They reported an increased demand for social services coupled with a significant retraction of community social service resources. To address these emerging social service gaps, participants described mounting a prompt and adaptable response that was facilitated by strong existing relationships with community partners.

Conclusion
Among MMCOs, the COVID-19 pandemic has emphasized the importance of addressing member social needs, and the need for broader consideration of what constitutes SDOH from a healthcare delivery standpoint.
Evaluating the antibody response to SARS-COV-2 vaccination amongst kidney transplant recipients at a single nephrology centre
Authors: Chukwu Chukwuma A. , Mahmood Kassir , Elmakki Safa , Gorton Julie , Kalra Phillip A. , Poulikakos Dimitrios , Middleton Rachel 
Published: March 2022

Background and objectives
Kidney transplant recipients are highly vulnerable to the serious complications of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infections and thus stand to benefit from vaccination. Therefore, it is necessary to establish the effectiveness of available vaccines as this group of patients was not represented in the randomized trials.

Design, setting, participants, & measurements
A total of 707 consecutive adult kidney transplant recipients in a single center in the United Kingdom were evaluated. 373 were confirmed to have received two doses of either the BNT162b2 (Pfizer-BioNTech) or AZD1222 (Oxford-AstraZeneca) and subsequently had SARS-COV-2 antibody testing were included in the final analysis. Participants were excluded from the analysis if they had a previous history of SARS-COV-2 infection or were seropositive for SARS-COV-2 antibody pre-vaccination. Multivariate and propensity score analyses were performed to identify the predictors of antibody response to SARS-COV-2 vaccines. The primary outcome was seroconversion rates following two vaccine doses.

Results
Antibody responders were 56.8% (212/373) and non-responders 43.2% (161/373). Antibody response was associated with greater estimated glomerular filtration (eGFR) rate [odds ratio (OR), for every 10 ml/min/1.73m2 = 1.40 (1.19–1.66), P<0.001] whereas, non-response was associated with mycophenolic acid immunosuppression [OR, 0.02(0.01–0.11), p<0.001] and increasing age [OR per 10year increase, 0.61(0.48–0.78), p<0.001]. In the propensity-score analysis of four treatment variables (vaccine type, mycophenolic acid, corticosteroid, and triple immunosuppression), only mycophenolic acid was significantly associated with vaccine response [adjusted OR by PSA 0.17 (0.07–0.41): p<0.001]. 22 SARS-COV-2 infections were recorded in our cohort following vaccination. 17(77%) infections, with 3 deaths, occurred in the non-responder group. No death occurred in the responder group.

Conclusion
Vaccine response in allograft recipients after two doses of SARS-COV-2 vaccine is poor compared to the general population. Maintenance with mycophenolic acid appears to have the strongest negative impact on vaccine response.
Pan-genome and resistome analysis of extended-spectrum ß-lactamase-producing Escherichia coli: A multi-setting epidemiological surveillance study from Malaysia
Authors: Dwiyanto Jacky , Hor Jia Wei , Reidpath Daniel , Su Tin Tin , Lee Shaun Wen Huey , Ayub Qasim , Mustapha Faizah Binti , Lee Sui Mae , Foo Su Chern , Chong Chun Wie , Rahman Sadequr 
Published: March 2022

ObjectivesThis study profiled the prevalence of extended-spectrum ß-lactamase-producingEscherichia coli(ESBL-EC) in the community and compared their resistome and genomic profiles with isolates from clinical patients through whole-genome sequencing.MethodsFecal samples from 233 community dwellers from Segamat, a town in southern Malaysia, were obtained between May through August 2018. Putative ESBL strains were screened and tested using antibiotic susceptibility tests. Additionally, eight clinical ESBL-EC were obtained from a hospital in the same district between June through October 2020. Whole-genome sequencing was then conducted on selected ESBL-EC from both settings (n = 40) for pan-genome comparison, cluster analysis, and resistome profiling.ResultsA mean ESBL-EC carriage rate of 17.82% (95% CI: 10.48%– 24.11%) was observed in the community and was consistent across demographic factors. Whole-genome sequences of the ESBL-EC (n = 40) enabled the detection of multiple plasmid replicon groups (n = 28), resistance genes (n = 34) and virulence factors (n = 335), with no significant difference in the number of genes carried between the community and clinical isolates (plasmid replicon groups, p = 0.13; resistance genes, p = 0.47; virulence factors, p = 0.94). Virulence gene marker analysis detected the presence of extraintestinal pathogenicE.coli(ExPEC), uropathogenicE.coli(UPEC), and enteroaggregativeE.coli(EAEC) in both the community and clinical isolates. MultipleblaCTX-Mvariants were observed, dominated byblaCTX-M-27(n = 12),blaCTX-M-65(n = 10), andblaCTX-M-15(n = 9). The clinical and community isolates did not cluster together based on the pan-genome comparison, suggesting isolates from the two settings were clonally unrelated. However, cluster analysis based on carried plasmids, resistance genes and phenotypic susceptibility profiles identified four distinct clusters, with similar patterns between the community and clinical isolates.ConclusionESBL-EC from the clinical and community settings shared similar resistome profiles, suggesting the frequent exchange of genetic materials through horizontal gene transfer.
Knowledge, attitude and practice of wearing mask in the population presenting to tertiary hospitals in a developing country
Authors: Furnaz Shumaila , Baig Natasha , Ali Sajjad , Rizwan Sahar , Khawaja Uzzam Ahmed , Usman Muhammad Abdullah , Haque Muhammad Tanzeel Ul , Rizwan Ayesha , Ali Farheen , Karim Musa 
Published: March 2022

Background
In the era of COVID-19 where there is emphasis on the importance of wearing a mask, wearing it rightly is equally important. Therefore, the purpose of this study was to assess the knowledge, attitude and practice of wearing a mask in the general population of a developing country at three major tertiary care hospital.

Materials and methods
Participants of this cross-sectional study were patients and attendants at three major tertiary care hospital of Karachi Pakistan. Selected participants, through non-probability convenient sampling technique, were interviewed regarding knowledge, attitude, and practice of wearing mask using an Urdu translated version of a questionnaire used in an earlier study. Three summary scores (0 to 100) were computed to indicate participants’ mask wearing practice, technique of putting it on, and technique of taking if off. Collected data were analyzed with the help of IBM SPSS version 19.

Results
A total of 370 selected individuals were interviewed, out of which 51.9% were male and mean age was 37.65±11.94 years. For more than 90% of the participants, wearing a face mask was a routine practicing during the pandemic. The mean practice score was 65.69±25.51, score for technique of putting on a face mask was 67.77±23.03, and score of technique of taking off a face mask was 51.01±29.23. Education level of participant tends to have positive relationship with all three scores, while presence of asthma or chronic obstructive pulmonary disease (COPD) as co-morbid had negative impact on mask wearing practice.

Conclusion
We have observed suboptimal knowledge, attitude and practice of wearing mask among the selected individuals. There is a continued need to spread awareness and educate general population about the importance of using a face mask, as well as the proper technique of wearing and taking off a face mask.