bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metaheuristic optimization based feature subset selection with deep belief network for stress prediction in working employees
Authors: Swaminathan Anitha , Muthuraman Vanitha 
Published: November 2022

SummaryStress is a physiological response to mental, emotional, or other physical challenges that humans face in real time situations, particularly in working environment. In recent times, there is a considerable increase in work related stress among working employees. The conventional stress assessment approaches are only based on self‐reported questionnaires that are subjective and could not offer instant details regarding the person's condition. So, continual observation of stress using the recent technologies can be used to effectively comprehend the stress patterns and offer better understandings about probable future involvements. So, the advent of deep learning (DL) models assists the stress prediction process to understand the patterns effectively and offer effective perceptions about possible future interventions. In this view, this article presents a gravitational search algorithm (GSA) based feature selection with deep belief network (DBN) model, named GSAFS‐DBN to predict stress among working employees. The proposed GSAFS‐DBN model aims to predict the stress level by the selection of features and optimal classification process. In addition, the GSAFS‐DBN technique involves the design of GSA based feature selection technique to choose an optimal subset of features. Moreover, DBN model is employed for the classification process to determine the proper class labels. Furthermore, Adamax optimization algorithm is applied to improve the training process of the DBN model. The effectiveness of the proposed model is examined using an own stress prediction dataset with 1197 samples of employees gathered from schools, banks, and universities and so forth. A detailed comparison study is implemented to highlight the enhanced predictive performance of the GSAFS‐DBN approach in terms of different evaluation measures like sensitivity, specificity, precision, accuracy, F‐score.
Ethical Frameworks for Disclosure of Alzheimer Disease Biomarkers to Research Participants: Conflicting Norms and a Nuanced Policy
Authors: Bunnik Eline M. , Smedinga Marthe , Milne Richard , Georges Jean , Richard Edo , Schermer Maartje H. N. 
Published: November 2022

ABSTRACTMore and more frequently, clinical trials for Alzheimer disease (AD) are targeting cognitively unimpaired individuals who are at increased risk of developing the disease. It is not always clear whether AD biomarker information should be disclosed to research participants: on the one hand, research participants may be interested in learning this information because of its perceived utility, but on the other hand, learning this information may be harmful, as there are very few effective preventive or therapeutic options available for AD. In this article, we bring together three separate sets of ethical guidance literature: on the return of individual research results, on an individual's right to access personal data, and on transparent enrollment into clinical trials. Based on these literatures, we suggest policies for the disclosure of AD biomarker test results in longitudinal observational cohort studies, clinical trials, and hybrid research projects, such as the European Prevention of Alzheimer's Dementia (EPAD) project, in which we served as an ethics team. We also present and critically discuss recommendations for disclosure of AD biomarkers in practice. We underscore that, as long as the clinical validity of AD biomarkers remains limited, there are good reasons to avoid actively disclosing them to cognitively unimpaired research participants.
Demonstration Project: Transitioning a Research Network to New Single IRB Platforms
Authors: Burr Jeri S. , Johnson Ann , Risenmay Annie , Bisping Stephanie , Serdoz Emily S. , Coleman Whit , Sward Katherine A. , Rothwell Erin , Dean J. Michael 
Published: November 2022

ABSTRACTSince the 2016 National Institutes of Health (NIH) mandate to use a single IRB (sIRB) in multicenter research, institutions have struggled to operationalize the process. In this demonstration project, the University of Utah Trial Innovation Center assisted the Collaborative Pediatric Critical Care Research Network to transition from using individually negotiated reliance agreements and paper‐based documentation to a new sIRB master agreement and an informatics platform to capture reliance documentation. Lessons learned that can guide other academic institutions and IRBs as they operationalize sIRBs included the need for sites to understand what type of engagement or reliance is required and their need to understand the difference between reliance and activation. Requirements around local review remain poorly understood. Further research is needed to determine approaches that can achieve the NIH vision of reviews becoming more efficient and improving study start‐up times, relieving administrative burden while advancing human research protections.
Isostructural Family of Rare‐Earth MOFs Synthesized from 1,1,2,2‐Tetrakis(4‐phosphonophenyl)ethylene
Authors: Steinke Felix , Otto Tobias , Ito Sho , Wöhlbrandt Stephan , Stock Norbert 
Published: November 2022

AbstractThe tetraphosphonic acid 1,1,2,2‐tetrakis(4‐phosphonophenyl)ethylene (H8L) was used as linker in the synthesis of eight new isostructural, phosphonate‐based metal‐organic frameworks of composition [M2(H2O)2(H2L)] ⋅ xH2O (M=Y3+, Tb3+, Dy3+, Ho3+, Er3+, Tm3+, Yb3+, Lu3+; 1.5<x<4), denoted as M‐CAU‐34. The compounds were synthesized under hydrothermal reaction conditions, using the corresponding metal nitrates as starting materials. The determination of the crystal structure was achieved by a combination of electron and powder X‐ray diffraction (PXRD) data. In addition, a thorough characterization by thermogravimetric and elemental analysis, IR‐ and Raman‐spectroscopy as well as H2O‐sorption is given.
The role of post‐trauma stress symptoms in the development of chronic musculoskeletal pain and disability: A systematic review
Authors: Jadhakhan Ferozkhan , Evans David W. , Falla Deborah 
Published: November 2022

AbstractBackground and ObjectiveTraumatic injuries are amongst the leading causes of death and disability in the world across all age groups. This systematic review aimed to (1) describe the role of post‐traumatic stress symptoms (PTSS) on the development of chronic pain and/or pain‐related disability following musculoskeletal trauma and (2) report pain and or pain‐related disability by injury severity/type.Database and Data TreatmentElectronic databases were searched, from inception to 31 November 2021 and updated on 10 May 2022, to identify studies in which: participants were adults aged ≥16 years sustaining any traumatic event that resulted in one or more musculoskeletal injuries; an outcome measure of PTSS was used within 3 months of a traumatic event; the presence of pain and/or pain‐related disability was recorded at a follow‐up of 3 months or more. Two reviewers independently screened papers and assessed the quality of included studies.ResultsEight studies were included. Owing to between‐study heterogeneity, the results were synthesized using a narrative approach. Five studies investigated the relationship between PTSS and pain. Participants with PTSS were more likely to develop persistent pain for at least 12 months post‐injury. Six studies assessed the relationship between PTSS and pain‐related disability. The results suggest that patients with PTSS had significantly higher disability levels for at least 12 months post‐injury.ConclusionFindings from this comprehensive systematic review support a clear relationship between PTSS post‐injury and future pain/disability, with the potential importance of certain PTSS clusters (hyper‐arousal and numbing).SignificanceThe findings of this systematic review indicate an association between PTSS reported within 3 months of a traumatic musculoskeletal injury and the development of longer‐term pain and disability. The PTSS clusters of ‘hyper‐arousal’ and ‘numbing’ appear to be of particular importance in this relationship.Prospero Registration NumberCRD42021285243.
Co‐mutation landscape and clinical significance of RAS pathway related gene mutations in patients with myelodysplastic syndrome
Authors: Ren Yanling , Lang Wei , Mei Chen , Luo Yingwan , Ye Li , Wang Lu , Zhou Xinping , Xu Gaixiang , Ma Liya , Jin Jie , Tong Hongyan 
Published: November 2022

AbstractSingle gene mutations in the RAS pathway are uncommon and of unknown significance in myelodysplastic syndrome (MDS) patients, RAS pathway‐related gene mutations (RASwaymut) as a whole may be significant and require further elucidation. The clinical and molecular data of 370 MDS patients who were newly diagnosed between 1 November 2016 and 31 August 2020 in our hospital were collected and retrospectively reviewed. RASwaymut were detected in 57 (15.41%) patients. Higher median percentage of marrow blasts (2% vs. 1%, P = 0.00), more co‐mutated genes (4, interquartile range [IQR]: 2–5. vs. 2, IQR:1–4, P = 0.00), more higher risk patients according to international prognostic scoring system‐revised (IPSS‐R) (80.70% vs. 59.11%, P = 0.002) as well as higher acute myeloid leukemia transformation rate (35.09% vs. 14.38%, P = 0.02) were observed in patients with RASwaymut when compared to those with wild type RAS pathway‐related genes (RASwaywt). The most frequent co‐mutated genes were ASXL1 (28.6%), TET2 (23.2%), U2AF1, RUNX1, TP53 (14.3%); DNMT3A (12.5%), among which ASXL1 mutation rate were significantly higher than those with RASwaywt (p < 0.05). RASwaymut had no significant effect on response to disease‐modifying treatment in MDS patients. However, Overall survivals (OS) of RASwaymut patients were significantly shorter than those with RASwaywt (16.05 m. vs. 92.3 m, P = 0.00), especially in patients with marrow blasts less than 5% (P = 0.002), normal karyotype (P = 0.01) and lower risk (P = 0.00). While multivariate prognostic analysis showed that RASwaymut co‐mutated with TET2 was an independent poor prognostic factor for all MDS patients (P = 0.00, hazrad ratio [HR] = 4.77 with 95% confidence interval [CI]: 2.4–9.51) and RASwaymut patients (P = 0.02, HR 2.76, 95% CI 1.21–6.29). In conclusion, RASwaymut was associated with higher IPSS‐R risk, higher incidence of leukemic transformation thus shorter OS in MDS patients, it could be viewed as a whole to predict poor prognosis. Co‐mutation with TET2 may promote disease progression and was an independent poor prognostic factor in MDS patients.
Spatiotemporal tracking of small extracellular vesicle nanotopology in response to physicochemical stresses revealed by HS‐AFM
Authors: Sajidah Elma Sakinatus , Lim Keesiang , Yamano Tomoyoshi , Nishide Goro , Qiu Yujia , Yoshida Takeshi , Wang Hanbo , Kobayashi Akiko , Hazawa Masaharu , Dewi Firli R. P. , Hanayama Rikinari , Ando Toshio , Wong Richard W. 
Published: November 2022

AbstractSmall extracellular vesicles (sEVs) play a crucial role in local and distant cell communication. The intrinsic properties of sEVs make them compatible biomaterials for drug delivery, vaccines, and theranostic nanoparticles. Although sEV proteomics have been robustly studied, a direct instantaneous assessment of sEV structure dynamics remains difficult. Here, we use the high‐speed atomic force microscopy (HS‐AFM) to evaluate nanotopological changes of sEVs with respect to different physicochemical stresses including thermal stress, pH, and osmotic stress. The sEV structure is severely altered at high‐temperature, high‐pH, or hypertonic conditions. Surprisingly, the spherical shape of the sEVs is maintained in acidic or hypotonic environments. Real‐time observation by HS‐AFM imaging reveals an irreversible structural change in the sEVs during transition of pH or osmolarity. HS‐AFM imaging provides both qualitative and quantitative data at high spatiotemporal resolution (nanoscopic and millisecond levels). In summary, our study demonstrates the feasibility of HS‐AFM for structural characterization and assessment of nanoparticles.
産褥期に肺血栓塞栓とともに発症した特発性冠動脈解離の1例(Spontaneous coronary artery dissection with pulmonary thromboembolism during puerperium)
Authors: 大祐 小林 , 嘉尚 越田 
Published: November 2022

要旨　31歳の女性で双胎妊娠切迫早産の診断のもと，約4か月の間，安静加療が続けられていた。妊娠36週目に無症候性に，1児の胎児死亡が認められ，緊急帝王切開術となった。術後2日目，呼吸苦と咽頭部の閉塞感を訴え，胸部造影CT検査の結果，肺血栓塞栓症が認められた。精査加療目的でICU入室となったが，12誘導心電図で広範囲誘導のST上昇と，心エコー図検査で心尖部を中心とした無収縮が認められ急性冠症候群が疑われた。右心負荷所見はなく，肺血栓塞栓症は長期安静の結果，慢性的に生じたものと推測され否定的であった。一方，手術侵襲や胎児死亡による身体的・精神的ストレスの影響から，たこつぼ症候群も疑われた。緊急冠動脈造影検査の結果，seg.7に解離による100%閉塞病変が認められ，特発性冠動脈解離と診断された。冠動脈形成術となり，解離遠位端にre–entryが作成され偽腔の血腫が吸引されたことで，血流の改善が得られた。基礎疾患のない妊産婦における産褥期の重篤な疾患として，肺血栓塞栓症の診断がなされたときも，特発性冠動脈解離を常に鑑別に考え，背景疾患や病態に応じて集学的に対処することが求められる。
下肢ガス壊疽を生じた盲腸癌による後腹膜穿通の1例(A case of retroperitoneal perforation due to colon cancer with gas gangrene)
Authors: 貴広 池下 , 優太郎 須藤 , 弘毅 清水 , 雄司 藤田 , 紀雄 秋山 
Published: November 2022

要旨　症例は75歳女性。右下腿の疼痛，発赤を主訴に近医受診しcomputed tomography（CT）検査を施行され，右後腹膜膿瘍および右下腿蜂窩織炎の診断で当院に救急搬送された。来院時，右鼠径部から下腿にかけて握雪感を伴う発赤および疼痛を認めたが，腹部所見は認めなかった。造影CTでは回盲部に腫瘍性病変を認め，腫瘍から連続し右腸腰筋周囲から下腿までガスを伴う膿瘍形成を認めた。盲腸癌の後腹膜穿通による下肢ガス壊疽の診断で同日緊急手術を行った。術中，結腸回盲部に腫瘤性病変を認めた。後腹膜への癒着が強く，剥離すると腫瘍は自壊し後腹膜側に穿通しており，腸腰筋周囲に多量の便を認めた。回盲部切除および右鼠径部，右大腿，右下腿のドレナージ術も同時に行った。術後3度の右下肢のデブリードマンを要した。その後縫合不全などの合併症なく，第79病日に退院となった。稀ではあるが，下肢ガス壊疽の原因として癌による後腹膜腔への穿通も考慮する必要がある。
The Embodied Journey of an Idea: An Exploration of Movement Creativity in Circus Arts
Authors: Richard Veronique , Glăveanu Vlad , Aubertin Patrice 
Published: November 2022

ABSTRACTKnowledge about embodied creativity is in its infancy. In circus arts, performers are nowadays ‘owning’ their creativity making this performance domain fruitful to study embodied creativity. Building on socio‐cultural creativity perspectives and radical embodied cognitive sciences, the current study aimed at exploring movement creativity by tracking the journey of embodied ideas in a Circus School. Specifically, this research questioned how the interactions between actors, audiences, affordances, and actions support the emergence and evolution of movement ideas. A narrative ethnographic research design, gathering process observationsin situ, was used to scrutinize the movement ideas generated by student‐artists, teachers, and artistic advisors over a 4‐month period. Reflexive thematic analysis led to the design of an exhaustive mapping which illustrates the key findings. Namely, the journey of an embodied idea is influenced by stimulating spaces and collaborative socio‐cultural environment which ignite the actors' desire to create. This desire, in turn, unfolds into multiple ideational pathways paved with research strategies (e.g., improvisation, constraints, variability) and emotions (i.e., pleasant and unpleasant). Embodied ideas then go through an assessment process leading (or not) to its growth. Results are discussed in light of embodied, pedagogical, and emotional considerations offering an alternative to the conceptualization of idea.
Examining the factor structure of the DSM‐5 Level 1 cross‐cutting symptom measure
Authors: Gibbons Alison B. , Farmer Cristan , Shaw Jacob S. , Chung Joyce Y. 
Published: November 2022

AbstractObjectivesThe DSM‐5 Level 1 Cross‐Cutting Symptom Measure (DSM‐XC) was developed by the American Psychiatric Association as a transdiagnostic mental health symptom survey. Despite its promise as a screening tool, few studies have assessed its latent dimensionality or provided guidance on interpreting responses. We examined the factor structure of the DSM‐XC in a convenience sample of participants with varying degrees of psychopathology.MethodsParticipants (n = 3533) were enrolled in an online study on the mental health impact of COVID‐19 (NCT04339790). We used a factor analytic framework with exploratory and confirmatory analyses to evaluate candidate factor solutions. Convergent validity analysis with concurrent study measures was also performed.ResultsSix‐factor and bifactor candidate solutions both had good fit and full measurement invariance across age, sex, and enrollment date. The six‐factor solution resulted in constructs labeled as: mood, worry, activation, somatic, thought, and substance use. A general psychopathology factor and two residual factors (mood and anxiety constructs) explained the variance of the bifactor solution.ConclusionsOur analysis supports that the DSM‐XC is a multidimensional instrument spanning many mental health symptoms. We provide scoring solutions for two factor structures that capture broader constructs of psychopathology. Use of a convenience sample may limit generalizability of findings.
Rhabdomyosarcoma xenotransplants in zebrafish embryos
Authors: Siebert Jakob , Schneider Michaela , Reuter‐Schmitt Daniela , Würtemberger Julia , Neubüser Annette , Driever Wolfgang , Hettmer Simone , Kapp Friedrich G. 
Published: November 2022

AbstractRhabdomyosarcomas (RMS) are the most common pediatric soft tissue sarcomas. High‐risk and metastatic disease continues to be associated with very poor prognosis. RMS model systems that faithfully recapitulate the human disease and provide rapid, cost‐efficient estimates of antitumor efficacy of candidate drugs are needed to facilitate drug development and personalized medicine approaches. Here, we present a new zebrafish‐based xenotransplant model allowing for rapid and easily accessible drug screening using low numbers of viable tumor cells and relatively small amounts of water‐soluble chemicals. Under optimized temperature conditions, embryonal RMS xenografts were established in zebrafish embryos at 3 h postfertilization (hpf). In proof‐of‐principle experiments, chemotherapy drugs with established clinical anti‐RMS efficacy (vincristine, dactinomycin) and the mitogen‐activated protein kinase kinase inhibitor trametinib were shown to significantly reduce the cross‐sectional area of the tumors by 120 hpf. RMS xenograft models in zebrafish embryos henceforth could serve as a valuable addition to cell culture and mammalian models of RMS and represent a rapid and cost‐effective solution for preclinical candidate drug testing.
Time‐dependent properties of high‐density polyethylene with wood/graphene nanoplatelets reinforcement
Authors: Al‐Maqdasi Zainab , Pupure Liva , Emami Nazanin , Joffe Roberts 
Published: November 2022

AbstractThe effect of graphene nanoplatelets (GNPs) on the long‐term performance of wood fiber/high‐density polyethylene (HDPE) composite is investigated by using short‐term creep tests with an efficient, faster data analysis approach. Previously, it was shown that the addition of GNPs at 15 wt% into HDPE reduces the viscoplastic (VP) strain developed during 2 h creep by ~50%. The current study shows that 25 and 40 wt% wood content in HDPE reduce the VP strains developed during 2 h creep time by >75% with no noticeable effect of the increased wood content. However, further addition of GNPs results in more than 90% total reduction in the VP strains. The current study shows that the development of the VP strains in the hybrid composites follows Zapas model. Viscoelastic (VE) response of these composites is nonlinear and thus is described by Schapery's model. Parameters for VP and VE models are obtained from the creep experiments and were validated in a separate loading‐unloading test sequence. Results show a very good agreement between experiments and predictions for the studied materials as long as the micro‐damage is not present.
Aspects of halloysite nanotubes integration in epoxy nanocomposites: Curing kinetics and deformation mechanism
Authors: AlKhateab Baidaa , Haghighi Poudeh Leila , Elmas Sinem , Sas Hatice S. , Yildiz Mehmet 
Published: November 2022

AbstractThe curing kinetics of diglycidyl ether of bisphenol A epoxy resin using amine‐based hardener in the presence of halloysite nanotubes (HNTs) are investigated by performing isothermal and dynamic differential scanning calorimetry measurements, followed by a detailed analysis of the experimental data via the kinetic free method and three common model‐based analysis. Kamal and Sourour model gave the best fit for the experimental data and thus, was further modified by Williams–Landel–Ferry diffusion control equations to calculate the diffusion constants near the glass transition temperature (Tg). The optimized model is used to find the curing kinetics parameters of epoxy/HNTs nanocomposites, and those finding are further validated and explained by performing rheometric measurements. Noncatalytic and autocatalytic curing reactions and diffusion constants are all functions of the amount of HNTs. HNTs shift the curing reaction slightly toward higher temperatures and promote etherification reactions, leading to an increase in the curing enthalpy, as extra bonds will be formed between HNTs and epoxy resin during the polymerization. The combination of acceleration and inhibition mechanisms dictates the complex kinetics of the reactions at high concentrations of HNTs, while the produced local topology of the polymeric network depends highly on HNTs weight ratio. Furthermore, to investigate the mechanical performance of the prepared nanocomposites under flexural loads, three points bending tests are performed in both modes, dynamic and static, followed by a fractography analysis of the fractured surfaces. The mechanical properties have improved by the addition of pristine HNTs without compromising the Tg of the polymer. This study provides a set of observational relationships between various chemical interactions during polymerization and the final topology and performance of the polymer, which in turn aims to bridge the gap in the literature between the curing kinetics of epoxy/HNTs nanocomposites and the performance of these nanocomposites under various thermal and mechanical stresses.
Electrospun coaxial microfiber‐based water detecting sensor using expansion pressure mechanism
Authors: Kim Huiseon , Shin Min Jae 
Published: November 2022

AbstractWe fabricated a water‐detecting sensor using an electrospun coaxial microfiber. Polydiacetylene (PDA) was used as the color‐change material, and poly(ethylene oxide) (PEO) or poly(vinyl alcohol) (PVA) as the core material. Although several polymeric materials have been used as shell materials, the water‐detecting sensor was fabricated only using polycaprolactone (PCL). When the core material (PEO or PVA) comes in contact with water, it expands, changing the color of the PDA in the shell from blue to red on account of the stress due to the expansion of the core material. Selecting a suitable polymer for the shell is essential for sensor operation. The elastic property of PCL is crucial for the sensor fabrication. The solvent of the electrospinning core material also affected the properties of the sensor. The rate of color change was controlled using the thickness of the core and shell of the coaxial microfibers, and the fastest observed time was 53 s.