bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromosomal Analysis of 129 Miscarried Conceptuses: A Retrospective Study
Authors: Gui Juan , Liu Qian , Wang Xiaochen , Xie Qingzhen , Ming Lei 
Published: January 2022

Abstract
Background

Embryonic chromosomal abnormality is one of the significant causative factors of pregnancy loss. Our goal was to investigate the differences of chromosomal abnormality between different conception modes in miscarried products of conception (POCs).
Methods

A retrospective study included 129 miscarried POCs from 81 women undergoing assisted reproductive technology (ART) and 48 spontaneous pregnant (SP) women during March 2019 to March 2021 in Renmin Hospital of Wuhan University. Subgroups were divided according to age, fertilization method, types of embryo transfer. The profiles of cytogenetic abnormalities in the miscarried POCs were measured via next-generation sequencing.
Results

The total chromosomal abnormality rate was 65.1%. No significant difference was found in the rate of chromosomal abnormalities between ART and SP group (63% vs. 68.8%, P = 0.505). However, the rate of chromosomal structural abnormalities was significantly increased in ART group (P = 0.02). There was no significant difference in the rate of chromosomal abnormalities when stratified by age (62.9% vs. 71.9%, P = 0.355) and frequency of abortion (66.7% vs. 63.2%, P = 0.678). In the patients aged < 35 years, the ART group had more frequent structural abnormality than SP group (P = 0.006). In the patients aged ≥ 35 years, numerical chromosomal abnormality was predominated in both groups (P = 0.655). Compared with the IVF fertilization subgroup, microdeletion was more frequent in the ICSI fertilization subgroup (80% vs.28.6%, P = 0.013). The rate of chromosomal abnormality in the fresh embryo transfer group was significantly higher than that in the frozen embryo transfer group (92.3% vs.50%, P = 0.0001), especially the structural abnormality (46.2% vs. 15.4%, P = 0.016).
Conclusion

Chromosomal abnormality is the main cause of spontaneous abortion, whether in SP or in ART patients. The incidence of structural abnormalities in miscarried POCs from ART patients was significantly increased and fresh cycles had higher frequency of chromosomal abnormalities than the frozen cycles, hints us that “freezing all” should be considered in the process of assisted reproduction if encountered hyper ovarian stimulation, to avoid the negative effect of high estrogen environment on embryo development.
Effects of Prebiotic Supplement on Gut Microbiota, Drug Bioavailability and Adverse Effects in Patients with Colorectal Cancer at Different Primary Tumor Locations Receiving Chemotherapy: Study Protocol for a Randomized Clinical Trial
Authors: Li Yanmin , Cao Hong , Fei Bojian , Bao Chuanqing , Xu Jianmin , Cao Huaxiang , Mao Yong , Chen Xiaoping , Gao Xiang , Zhao Wei , Zhang Feng 
Published: January 2022

Abstract
Background: The prevalence of colorectal cancer (CRC) worldwide is a huge challenge to human health. Primary tumor locations found to impact prognosisand response to therapy. The important role of gut microbiota in the progression and treatment of CRC has led to many attempts of alleviating chemotherapy-induced adverse effects using microecologics. However, the underlying mechanism of the difference in the prognosis of different primary tumor locations and the synergistic effect of prebiotics on chemotherapy need to be further elucidated. This study aims to explore the differences in tumor microbiota and examine the effectiveness of xylooligosaccharides (XOS) on gut microbiota, adverse effects, and bioavailability of chemotherapy drugs in CRC patients at different primary tumor locations.Methods: This is a double-blinded, randomized, parallel controlled clinical trial. Participants with left-sided CRC (LSCRC, n = 50) and right-sided CC (RSCC, n = 50) will randomly allocated to prebiotic group (n = 25) or control group (n = 25) and will receive either a daily XOS (3 g/d) or placebo, respectively, for 12 weeks. The primary outcomes will be the differences in the mucosa microbiota composition at different tumor locations, and differences in gut microbiota composition, adverse effects, and blood concentration of capecitabine posttreatment. The secondary outcomes will include other blood indicators, short-chain fatty acids (SCFAs) concentration, quality of life, and mental health.Discussion: This study will reveal the potential benefits of prebiotic for improving the gut microbiota composition, alleviating the adverse effects, and improving the efficacy of chemotherapy in patients with CRC. In addition, this study will provide data on the different distribution of tumor microbiota and the different changes of gut microbiota during treatment in LSCRC and RSCC, which may provide novel insights into personalized cancer treatment strategies based on primary tumor locations and gut microbiota in the future.Trial registration: Chinese Clinical Trial Registry(www.chictr.org.cn): ChiCTR2100046237. Registered on 12 May 2021.
Acute Exposure to Simulated High-altitude Hypoxia Alters Gut Microbiota in Mice
Authors: Wang Feng , Zhang Han , Xu Tong , Hu Youchun , Jiang Yugang 
Published: January 2022

Abstract
Gut microbiota bears adaptive potential to different environments, but little is known regarding its responses to acute high-altitude exposure. This study aimed to evaluate the microbial changes after acute exposure to simulated high-altitude hypoxia. C57BL/6J mice were divided into hypoxia and normoxia groups. The hypoxia group was exposed to a simulated altitude of 5500 m for 24 hours above sea level. The normoxia group was maintained in low-altitude of 10 m above sea level. Colonic microbiota was analyzed using 16S rRNA V4 gene sequencing. Compared with the normoxia group, shannon, simpson and Akkermansia were significantly increased, while Firmicutes to Bacteroidetes ratio and Bifidobacterium were significantly decreased in the hypoxia group. The hypoxia group exhibited lower mobile element containing and higher potentially pathogenic and stress tolerant phenotypes than those in the normoxia group. Functional analysis indicated that environmental information processing was significantly lower, metabolism, cellular processes and organismal systems were significantly higher in the hypoxia group than those in the normoxia group. In conclusion, acute exposure to simulated high-altitude hypoxia alters gut microbiota diversity and composition, which may provide a potential target to alleviate acute high-altitude diseases.
Association Between IL-23 And Coronary Arterial Lesions In Children With Kawasaki Disease
Authors: Su Ya , Feng Siqi , Liu Ruixi , Yi Qijian 
Published: January 2022

Abstract
The pathogenesis of coronary artery lesions (CALs) in KD patients has been thought of as an unknown stimulus that triggers an inflammatory cascade with activation of the immune system. However, interleukin-23 (IL-23) is supposed as a key cytokine in inflammatory and autoimmunity diseases. The role of IL-23 in the pathogenesis of CALs has not been fully elucidated. This study explored the relationship between the serum IL-23 levels and CALs in patients with KD. We collected blood specimens from 90 children with KD before intravenous immunoglobulin (IVIG) therapy. Levels of IL-23, IL-6, IL-17A, IL-10, MCP-1 and VEGF were measured in 190 cases, including 4 groups: KD with CALs (n = 46), KD without CALs (n = 44), febrile control group, (FC, n = 40) and normal control group, (NC, n = 60). Clinical parameters were tested in all subjects. IL-23 was significantly elevated in the KD group compared with the febrile and normal control groups, especially increased in the KD patients with CALs. Serum levels of IL-23 in KD patients were positively associated with WBC, CRP, IL-6, IL-17A, IL-10, MCP-1, and VEGF in children with KD. IL-23 may be involved in the pro-inflammatory process and the pathogenesis of CALs in KD patients.
Short circuit fire risk assessment in investigating and examining fires caused by emergency modes in overhead transmission lines
Authors: Kozlova Yu. S. 
Published: January 2022

Emergency modes (short circuits) in electric power system and equipment are the main technical cause of fires. However, it is not always possible to prove the involvement of a particular operating mode in a fire. The fire hazard can be due to three components: a fuel load, an oxidizer and an ignition source. Since overhead transmission lines are used in an open space, they are oxidized. The presence of a fuel load is confirmed by a fire. The source of ignition should be identified. The aim of the study is to develop an algorithm for assessing the fire hazard for short circuits in overhead transmission lines with 1000 V. The study was conducted using scientific analysis, physical experiment and simulation. The ignition source is due to the appearance of an energy source with parameters sufficient to ignite a fuel load. The probability of ignition in overhead line wires depends on the probability of occurrence of the short circuit itself ( Qi (v1) ) , the probability of failure of protection devices ( Qi (v2) ), and the probability that the electric current value in the event of a fault is in the range of fire hazard values (Qi(z)). The values of the first two components are determined on the basis of statistical data, taking into account the theory of reliability. The third component is based on the experiment results. The experimental studies made it possible to establish the ranges of fire hazard values for uninsulated aluminum wires of various cross-sections, thereby providing the possibility of calculating ( Qi (z). Using the data obtained and information about the nature of changes in short-circuit currents and performance characteristics of protection devices, depending on the line length, an algorithm for assessing the fire hazard for a short circuit was developed. The results make it possible to assess the fire hazard for short circuits in various sections of the electrical network, made by overhead transmission lines, and to establish the involvement of sparks generated by short circuits in a fire
Development of fully superconducting 5 MW aviation generator with liquid hydrogen cooling
Authors: Dezhin Dmitry , Ilyasov Roman 
Published: January 2022

The use of liquid hydrogen as a fuel will be inevitable in the aviation of the future. This statement means that manufacturers will also implement liquid hydrogen for cooling all superconducting aviation equipment of an electric propulsion system. The development of fully electric aircraft is the most promising solution in this case. Scientists from the Department of electrical machines and power electronics of Moscow aviation institute have conducted calculations and theoretical researches of critical specific mass-dimensional parameters (MW/ton and MW/m3 at 21 K) of fully superconducting aviation synchronous generator of the electric propulsion system. The results are in this article.
The article discusses the results 3D finite element modeling (FEM) simulation of a 5 MW fully superconducting synchronous generator with combined excitation. Superconducting armature and axial excitation windings based on second generation high temperature superconductors (HTS-2G) are located on the stator, which makes it possible to contactlessness and the absence of sliding seals. A dry gap will reduce gas-dynamic losses and increase the nominal peripheral speed of the rotor. The use of liquid hydrogen as a coolant makes it possible to significantly increase the linear load of the generator, and high current densities to reduce the cross-sectional area of the coils, which will make it possible to place them in individual cryostats in the future. Individual cryostats will allow to remove the heat release of magnetic losses from the cryogenic zone and reduce the consumption of refrigerant. For the purpose of internal redundancy of the HTS coils, the machine has a complete set of reserve winding made of ultrapure aluminum, also cooled by liquid hydrogen. If the superconducting coils get out of the stand, the generator will provide 15 % power on standby
Development of a method for the combined control of the hardness of winding textile package
Authors: Nuriyev Mahammadali Nuraddin , Jafarova Afet Mastan 
Published: January 2022

Analysis of methods for determining the hardness of the winding shows that all existing methods require a lot of labor and time. When measuring the layer-by-layer hardness, the known methods do not allow obtaining continuous values, and in the case of measuring the hardness of packages of complex shape (conical bobbins, cops, spinning cobs, etc.), it requires a calculation using cumbersome formulas. In this case, the main difficulties arise in determining the volume of the layers of the winding, which in the general case have a complex configuration, and due to defects in the winding may have an irregular shape. Obviously, the described technique is rather cumbersome, and a lot of measurements and calculations are required to obtain a graph of the change in the winding hardness along the package radius. The construction of a graph of the change in hardness along the generatrix using a special device is generally problematic, since placement of more than three sources on the device is impossible due to the size of the meters, and the construction of the curve by three points cannot be considered satisfactory. Winding hardness is one of the most important parameters, on which many technological properties of the package depend. Indeed, with an increase in the hardness of the winding, the amount of material in the same volume increases, which makes it possible to replace packages less often, both on the machine that forms them, and at the subsequent transition. As a result, the equipment useful time increases.
It was found that the hardness of the winding is closely related to its rigidity, and hence to the stability during transportation. The hardness of the winding affects the permeability of the package when it is treated with solutions. In this case, a huge role is played not only by the average value of the hardness, but also by its distribution over the layers
Increasing the mechanical properties of structural cast iron for machine-building parts by combined Mn – Al alloying
Authors: Popov Stanislav , Frolova Liliia , Rebrov Oleksii , Naumenko Yevheniia , Postupna Оlenа , Zubko Vladyslav , Shvets Pavel 
Published: January 2022

The object of research in this work was cast iron for machine-building parts, alloyed with Al. The possibility of improving the mechanical properties of cast iron by choosing the optimal Mn – Al combinations, depending on the carbon content in the cast iron, was determined. The study was carried out on the basis of available retrospective data of serial industrial melts by constructing the regression equation for the ultimate strength of cast iron in the three-factor space of the input variables C – Mn – Al. The optimization problem was solved by the ridge analysis method after reducing the dimension of the factor space by fixing the carbon content at three levels: C = 3 %, C = 3.3 %, and C = 3.6 %.
It was found that the maximum values of the ultimate strength are achieved at the minimum level of carbon content (C = 3%) and are in the range of values close to 300 MPa. In this case, the Al content is in the range (2.4–2.6) %, and the Mn content is about 0.82 %. With an increase in the carbon content, there is a tendency to a decrease in the content of Mn and Al in the alloy, which is necessary to ensure the ultimate strength close to 300 MPa. The results of the ridge analysis of the response surface also showed that at the upper limit of the carbon content (C = 3.6%), it is not possible to reach the ultimate strength of 300 MPa in the existing range of Mn and Al variation.
All solutions are verified for the following ranges of input variables C = (2.94–3.66) %, Mn = (0.5–1.1) %, Al = (1.7–2.9) %.
Graphical-analytical descriptions of the optimal Mn – Al ratios are obtained, depending on the actual content of carbon in the alloy, which make it possible to purposefully select the optimal melting modes by controlling the tensile strength of the alloy
The problem of low adherence to antiresorptive therapy with bisphosphonates: solutions
Authors: Yakushevskaya O. V. 
Published: January 2022

Over the past several decades, there has been a global aging of the population around the world. The demographic situation in the Russian Federation is no exception, being a natural result of an increase in the life expectancy of the population. In clinical practice, geriatric diseases have been identified and are widely studied, which deserve priority attention due to a sharp decline in the quality of life of elderly patients. Osteoporosis is called a “silent epidemic” among elderly and senile patients. This disease is associated with a high risk of low-traumatic fractures of various localization. The imperfect rehabilitation program after complex fractures and its insufficient funding are forcing clinicians to focus on more cost-effective solutions to this problem – the prevention and treatment of osteoporosis. Osteomodifying agents are widely used by physicians of various specialties. Bisphosphonates effectively reduce the risk of low-traumatic fractures against the background of an increase in bone mineral density. The level of effectiveness of bisphosphonates depends on the patient’s adherence to antiresorptive therapy and the degree of compensation for vitamin D and serum calcium. Low adherence to osteoporosis therapy is based on the need for long-term use of bisphosphonates and a different spectrum of adverse events. In the article, using alendronate as an example, the problem of low adherence to antiresorptive therapy will be considered and ways to solve it are presented.
Non-hormonal therapy of patients with fibrocystic mastopathy in combination with endometrial hyperplasia
Authors: Borovikov I. O. , Kutsenko I. I. , Bulgakova V. P. , Borovikova O. I. 
Published: January 2022

Introduction. The article presents a comparative analysis of the treatment of patients with combined estrogen-dependent pathology of female reproductive system: fibrocystic mastopathy and endometrial hyperplasia without atypia. The experience of treatment with an indole-carbinol-containing drug as monotherapy while using a levonorgestrel-releasing intrauterine system is presented.Aim. To evaluate the clinical efficacy of indolecarbinol in the treatment of patients with combined estrogen-dependent pathology of the female reproductive system.Materials and methods. The authors studied the responses to the treatment of patients with fibrocystic mastopathy and simple endometrial hyperplasia (n = 65) with the indole-carbinol-containing drug at a dose of 400 mg once daily for 12 months. All patients were divided into two groups: Group I (n = 32) – women who refused hormone therapy (indole-carbinol monotherapy); Group II (n = 33) – the use of indole-carbinol while using the levonorgestrel-releasing intrauterine system. Diagnostic methods: clinical and laboratory examination, ultrasound examination of mammary glands and pelvic organs, mammography, nipple discharge cytology at baseline and 6 and 12 months after the start of therapy. Before study group assignment to treatment, all patients underwent hysteroscopy with endometrial biopsy and histological examination. Descriptive statistics were used to evaluate the data: p-values below 0.05 were considered statistically significant.Results and discussion. The presented experience in treating women with combined pathology of the female reproductive system (fibrocystic mastopathy and endometrial hyperplasia without atypia) with the indole-carbinol-containing drug showed high clinical efficacy in mastopathy (relief of mastodynia (83.0 ± 1.6%), improvement of the ultrasound view of BI-RADS (66.1 ± 1.4%), reductions in mammographic density (66.1 ± 2.1%, p < 0.05)), high tolerability and satisfactory compliance. This drug combined with hormone therapy is recommended for the treatment of endometrial hyperplasia.Сonclusion. The use of indole-carbinol in the treatment of benign hyperplastic processes in mammary glands and endometrial hyperplasia is pathogenetically substantiated and shows high clinical efficacy
Experience with the triple fixed combination in patients with chronic obstructive pulmonary disease
Authors: Demko I. V. , Mamaeva M. G. , Sobko E. A. , Kraposhina A. Yu. , Gordeeva N. V. 
Published: January 2022

Chronic obstructive pulmonary disease (COPD) is one of the most important problems of modern medicine associated with a high mortality rate, high costs of treatment and relief of exacerbations of COPD. The main objectives of COPD treatment are symptom control, reduce the frequency of exacerbations and hospitalizations, and reduced risk of exacerbation in the future. The recommendations of the GOLD initiative propose a treatment approach based on the assessment of exacerbation rates external respiratory function indicators (spirometric classification of GOLD), the severity of symptoms assessed on the CAT test and mMRC. When choosing therapy, the physician must first of all take into account the effectiveness, safety of the drug, adherence to treatment in order to achieve the therapeutic goals of treating patients with COPD. The change in therapeutic approaches in COPD treatment is associated with the accumulation of knowledge in physiology, clinical pharmacology, and the isolation of new clinical phenotypes of COPD. Currently, the main classes of drugs for the treatment of COPD are long-acting beta-agonists (LABA), longacting anticholinergics (LAMA), and inhaled glucocorticosteroids (ICS). The evolution of therapeutic approaches in COPD treatment has led to the creation of new fixed inhalation combinations of the main groups of drugs for COPD treatment. The therapeutic strategies recommended by GOLD and the Russian Federal Guidelines determine the long-term goals of COPD treatment – the impact on the risk of exacerbations in the future. The presented clinical observation of a patient with severe COPD demonstrates the effectiveness of a triple fixed combination vilanterol/umeclidinium/fluticasone furoate 55/22/92 μg as a basic therapy. The chosen treatment strategy not only reduces the severity of the symptoms of the disease, but also reduces the risk of exacerbations in the future.