bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of molecular responses and outcomes between BCR::ABL1 e14a2 and e13a2 transcripts in chronic myeloid leukemia
Authors: Su Yi‐Jiun , Kuo Ming‐Chung , Chen Tsai‐Yun , Wang Ming‐Chung , Yang Youngsen , Ma Ming‐Chun , Lin Tung‐Liang , Lin Tung‐Huei , Chang Hung , Teng Chieh‐Lin Jerry , Hsiao Pei‐Ching , Chen Chih‐Cheng , Wang Po‐Nan , Shih Lee‐Yung 
Published: July 2022

AbstractSeveral studies have compared the molecular responses between e14a2 and e13a2 BCR::ABL1 transcripts in chronic myeloid leukemia (CML) patients treated with front‐line imatinib, but there were very limited studies on nilotinib or dasatinib‐treated patients. We retrospectively analyzed the molecular responses in 1124 CML patients with the e14a2 or e13a2 transcript receiving front‐line imatinib, nilotinib or dasatinib treatment. Patients with the e14a2 transcript had higher optimal response rates than those with the e13a2 transcript at 12 months in the imatinib‐treated group, and 6 and 12 months in the nilotinib‐treated group. The optimal response rates were not significantly different between the two transcripts in the dasatinib‐treated group at landmark molecular responses. With a median follow‐up time of 48.4 months, higher cumulative incidences of BCR::ABL1 International Scale ≤1% and major molecular response were observed in patients with the e14a2 rather than the e13a2 transcript receiving front‐line imatinib or nilotinib treatment, but not in dasatinib‐treated patients. The progression‐free survival and overall survival did not differ between the two transcripts in all three treatment groups. In view of the speed and depth of molecular responses, BCR::ABL1 transcript subtypes might provide helpful information in selecting a front‐line tyrosine kinase inhibitor for individual young patients with future potential treatment‐free remission.
Influence of the number of implants in the edentulous mandible on chewing efficacy and oral health‐related quality of life—A within‐subject design study
Authors: Passia Nicole , Chaar Mohammed Sad , Krummel Anna , Nagy Andreas , Freitag‐Wolf Sandra , Ali Shurouk , Kern Matthias 
Published: July 2022

AbstractObjectivesTo investigate the chewing efficiency and oral health‐related quality of life of edentulous patients wearing complete dentures, successively supported by one, two, and three implants in the mandible.MethodsThirteen (13) edentulous patients of at least 50 years of age received three implants in the mandible. After a conventional submerged healing period, the central implant was uncovered and connected to the denture base using a stud attachment. Two months later, chewing efficacy was evaluated, and the two lateral implants were uncovered and connected to the denture base. The central retention element was replaced by a short healing abutment with no connection to the denture base. Chewing efficiency was evaluated two months later. Afterward, the healing abutment of the central implant was replaced by a stud attachment and again connected to the denture base. Two months later, chewing efficacy was evaluated again. Oral health‐related quality of life (OHRQoL) was measured at each recall visit using the summary score of the oral health impact profile. For statistical analysis of chewing efficacy, the changes from baseline (with no implants) to one, two, and three implants were used and tested by analysis of variance with repeated mesurements.ResultsChewing efficacy clearly increased after implant loading, with a significant increase when two implants were loaded (p ≤ .05), compared to the chewing efficacy with no implants. OHRQoL also significantly improved after implant loading.ConclusionsWithin the limitations of the present clinical trial regarding the number of patients, chewing efficacy as well OHRQoL of edentulous patients improve after implant placement in the mandible, irrespective of the number of implants. The best chewing efficacy was achieved with two implants.
Automated interpretation of the pulmonary function test by a portable spirometer in Chinese adults
Authors: Zhou Jun , Wang Ping , Guo Leixin , Cao Jin , Zhou Min , Dai Ranran 
Published: July 2022

AbstractIntroductionA portable spirometer is a promising alternative to a traditional pulmonary function test (PFT) spirometer for respiratory function evaluation.ObjectivesThis study aimed to investigate the accuracy of automated interpretation of the PFT measured by a portable Yue Cloud spirometer in Chinese adults.MethodsThe PFT was performed to evaluate subjects prospectively enrolled at Ruijin Hospital (n = 220). A Yue Cloud spirometer and a conventional Jaeger MasterScreen device were applied to each patient with a 20‐min quiescent period between each measurement. Pulmonary function parameters, including forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF), maximal expiratory flow at 25%, 50%, and 75% of the FVC (MEF25, MEF50, and MEF75, respectively), and maximal mid‐expiratory flow (MMEF), were compared by correlation analyses and Bland–Altman methods. The Yue Cloud spirometer automatically interpreted the PFT results, and a conventional strategy was performed to interpret the PFT results obtained by the Jaeger machine. Concordance of the categorization of pulmonary dysfunction, small airway dysfunction, and severity was analyzed by the kappa (κ) statistic.ResultsSignificantly similar correlations of all variables measured with the two spirometers were observed (all p < 0.001). No significant bias was observed in any of the measured spirometer variables. A satisfactory concordance of pulmonary function and severity classification was observed between the automated interpretation results obtained with the Yue Cloud spirometer vs. a conventional spirometer interpretation strategy (all κ > 0.80).ConclusionThe portable Yue Cloud spirometer not only yields reliable measurements of pulmonary function but also can automatically interpret the PFT results.
First‐in‐human, randomized, double‐blind, placebo‐controlled, dose escalation trial of the anti‐herpes simplex virus monoclonal antibody HDIT101 in healthy volunteers
Authors: Blank Antje , Hohmann Nicolas , Dettmer Marlen , Manka‐Stuhlik Anette , Mikus Gerd , Stoll Felicitas , Stützle‐Schnetz Marlies , Thomas Daniel , Exner Evelyn , Schmitt‐Bormann Beate , Schaller Torsten , Laage Rico , Schönborn‐Kellenberger Oliver , Arndt Michaela , Haefeli Walter E. , Krauss Jürgen 
Published: July 2022

AbstractHDIT101 is a first‐in‐class humanized monoclonal antibody recognizing a conserved epitope in glycoprotein B, a target present on the surface of herpes simplex virus 1 (HSV‐1) and HSV‐2 particles as well as on virus‐infected cells. This was a first‐in‐human, single‐center, double‐blind, placebo‐controlled trial in 24 healthy volunteers, randomized 3:1 (placebo:active) in each of the six dose levels with escalating doses up to 12,150 mg HDIT101. HDIT101 was administered intravenously, to study safety, pharmacokinetics (PKs), and immunogenicity. HDIT101 was well‐tolerated in all recipients and no serious or severe adverse events, no infusion‐related reactions, and no events suggestive of dose limiting off‐target toxicity occurred. The mean serum exposure (area under the curve from zero to infinity [AUC0‐∞]) of HDIT101 showed a linear increase from 4340 h*μg/ml at a dose of 50 mg to 1,122,247 h*μg/ml at a dose of 12,150 mg. No immunogenic effects following HDIT101 exposure were observed at any of the applied doses. HDIT101 demonstrated the expected PK properties of a monoclonal antibody was well‐tolerated, and could be safely administered even at excessively high doses that may be required for treatment of patients with septical HSV spread.
Performance of breast fine needle aspiration as an initial diagnostic tool: A large academic hospital experience
Authors: Chen Zhengshan , Salibay Christine , Elatre Wafaa , Naritoku Wesley Y. , Ma Yanling , Martin Sue Ellen , Wang Tiannan 
Published: July 2022

AbstractBackgroundThe clinical performance of the Yokohama reporting system for breast cytology remains uncertain.MethodsIn this study, we retrospectively evaluated 318 breast fine needle aspirations (FNABs) from Los Angeles County Hospital over a five‐year period, analysing data for breast cytology, histology, and radiology.ResultsAmong 318 breast FNAB cases, 78.3% (249/318) were benign and 5.3% (17/318) malignant. Of 83 cases with follow‐up histology, 14.5% (12/83) were insufficient, 66.3% (55/83) were benign, and 16.9% (17/83) were malignant. Of 55 benign cases, 61.8% (34/55) were fibroadenoma and 9 (9/55, 16.4%) were fibrocystic changes. Two cases were diagnosed as “atypical” but confirmed “benign” on core needle biopsy (CNB). No “suspicious” cases were found. Seventeen malignant cases were confirmed by CNB, including 70.6% (12/17) invasive ductal carcinoma, 11.8% (2/17) invasive lobular carcinoma, and one malignant phyllodes tumour. Receptor studies on cell blocks of three malignant cases showed concordant results with CNB results. In addition, 82.2% (148/180) of lesions with Breast Imaging‐Reporting and Data System (BI‐RADS) scores of 2 or 3 were benign and 92.3% (12/13) BI‐RADS score 5 lesions were malignant on FNAB. Finally, 90% (67/74) of BI‐RADS 4a lesions were benign, and 97% (36/37) of fibroadenomas were BI‐RADS score 4a.ConclusionThis, by far the largest U.S. breast cytology study, showed 93.3% sensitivity, 100% specificity, 100% positive predictive value, and 98.2% negative predictive value for breast FNAB. Women with breast lesions of BI‐RADS score 3 or less have a low risk of malignancy; FNAB would contribute to the reduction of excisional biopsies. FNAB can be considered as an initial diagnostic tool for BI‐RADS 4 mass/lesions and satellite lesions, as well as for triaging patients.
Prospective study of a new endoscopic duodenal–jejunal bypass sleeve in obese patients with nonalcoholic fatty liver disease (with video)
Authors: Ren Mengting , Zhou Xinxin , Yu Mosang , Cao Yang , Xu Chengfu , Yu Chaohui , Ji Feng 
Published: July 2022

ObjectivesTo evaluate the safety and efficacy of a new endoscopic duodenal–jejunal bypass sleeve (DJBS) in obese patients with nonalcoholic fatty liver disease (NAFLD), while in situ for 3 months, and at 6 months postexplantation.MethodsPatients with obesity and NAFLD were enrolled in this single‐center, prospective study, wherein the TONGEE DJBS (Tangji Medical, Hangzhou, China) was implanted for 3 months. Primary outcomes were weight loss and changes in hepatic steatosis. Secondary outcomes included changes in liver enzymes, glycemic control, and lipid profile and device safety.ResultsTwenty‐six patients (age 35.2 ± 7.2 years; 61.5% women) underwent DJBS implantation. At 3 months, bodyweight change from baseline was −8.0 ± 3.6 kg (P < 0.001), corresponding to 8.9 ± 4.0% of total bodyweight. Hepatic steatosis significantly improved based on controlled attenuation parameter, hepatic steatosis index, and fatty liver index (P < 0.001). Liver enzymes, insulin resistance, and metabolic parameters were also improved. At 6 months postexplantation, weight loss and improvements in hepatic steatosis and liver enzyme levels remained statistically significant. Only one patient had a serious adverse event, namely, upper gastrointestinal hemorrhage.ConclusionsThree‐month TONGEE DJBS implantation resulted in significant weight loss and improvement in hepatic steatosis, liver enzymes, insulin resistance, and metabolic parameters in obese patients with NAFLD. Randomized controlled trials are required to further elucidate these initial findings.
A core outcome set for lower limb orthopaedic surgery for children with cerebral palsy: An international multi‐stakeholder consensus study
Authors: Almoajil Hajar , Hopewell Sally , Dawes Helen , Toye Francine , Theologis Tim 
Published: July 2022

AimTo develop a core set of outcome domains to be measured in clinical studies on lower limb orthopaedic surgery for ambulant children with cerebral palsy (CP) that represents the priorities of an international multi‐stakeholder group (children, parent/carers, and health professionals).MethodPotential outcome domains were identified through literature review and qualitative interviews with key stakeholders. These were scored in an international two‐round Delphi survey, using a 9‐point Likert scale. A final consensus meeting with key stakeholders agreed on the most important outcome domains and refined the core outcome set (COS).ResultsOne hundred and sixty‐one health professionals and 36 individuals with CP and their parents/carers rated 21 of 41 outcomes as important in the Delphi survey. The final consensus group agreed 19 outcomes within eight domains to be included in the final COS: pain and fatigue, lower limb structure, motor function, mobility (daily life activities), gait‐related outcomes, physical activity, independence, and quality of life.InterpretationA COS for lower limb orthopaedic surgery for children with CP was developed. Incorporating this in the design of future clinical studies will provide a more holistic assessment of the impact of treatment while allowing meaningful comparisons and future synthesis of results from primary studies.What this paper adds

Eight core outcome domains were identified as important to measure in future clinical research.
Key stakeholders perceived pain, balance and fall, and independence as very important outcomes.
Six contextual factors were identified as essential in surgical decision‐making.
Nutrition and food literacy among young Canadian adults living with type 1 diabetes
Authors: Itzkovitz Alexandra , Maggio Vanessa , Roy‐Fleming Amélie , Legault Laurent , Brazeau Anne‐Sophie 
Published: July 2022

AbstractAimNutrition and food literacy encompasses knowledge, skills and confidence to prepare healthy meals. This project aimed to assess and compare the proportion of young Canadian adults (18–29 years old) living with type 1 diabetes and without diabetes (controls) who demonstrated adequate nutritional health literacy.MethodsThis cross‐sectional study involved participants completing an online survey that included questions on socio‐economic status, nutrition knowledge, confidence and skills in meal preparation and the Short Food Literacy Questionnaire (SFLQ). Proportion of participants with adequate SFLQ score (i.e. ≥34/52) was compared between the groups (two‐sample t‐test).ResultsAmong the 236 people living with type 1 diabetes and 191 controls (81.5% women), mean age was 24 ± 3 years for people living with type 1 diabetes and 22 ± 3 years for controls (p < 0.001). More people living with type 1 diabetes reported adequate SFLQ score (people living with type 1 diabetes 88.0% vs. Controls 68.0%; p < 0.001). Similarly, majority of people living with type 1 diabetes prepared their own meals compared to the controls (74.5% vs. 47.6%; p < 0.001). Enhanced SFLQ score was associated with higher cooking skills (p = 0.02) and confidence (p < 0.01) in preparing healthy meals.ConclusionsLiving with type 1 diabetes was associated with greater SFLQ scores among young Canadian adults. Having the independence, the confidence and skills in meal preparation were contributing factors.
Sources of occupational stress amongst dentistry academics
Authors: Teixeira Hugo , Lalloo Ratilal , Evans Jane L. , Fuss Janet , Pachana Nancy A. , Burton Nicola W. 
Published: July 2022

AbstractBackgroundDentistry professionals may experience significantly higher occupational stress than other health professionals and dentistry academics may have specific work content and context sources of stress.AimsThe aim of this study is to identify common sources of occupational stress, and how these are associated with wellbeing, in dentistry academics.Materials & MethodsA cross‐sectional online survey with staff in Dentistry departments in Australia and New Zealand. Assessment included 23 items from five general domains of occupational stress from the NIOSH—Generic Job Stress Questionnaire, a 23‐item list of sources of stress and the 22‐item Psychological General Well‐Being Index. Analyses used descriptive statistics and multiple linear regression.ResultsA total of 107 respondents (average age 50 ± 11.7 years, 56.8% men) completed the survey. Leading sources of occupational stress were job future, time pressure at work, work overload, and administration demands. A multiple linear regression model significantly predicted wellbeing, F(8,77) = 13.141, p = .000, adj.R2 = .53, but there were no significant associations for any of the specific sources of stress.ConclusionThe combination of time pressure, workload and responsibility, job dissatisfaction, low social support, and uncertain job future was inversely associated with wellbeing amongst these dentistry academics. Future studies should consider the development and evaluation of interventions to address these concerns.
Investigating periodontal diagnosis and treatment at one dental school
Authors: DeStaffany Amy M. , Gurenlian Jo Ann R. , Bono Leciel K. 
Published: July 2022

AbstractIntroductionThe purpose of this study was to evaluate whether patients at one dental education institution received appropriate care based on their periodontal diagnosis in a timely manner.Materials and MethodsThis study used a retrospective design to evaluate data from July 2018 to February 2020. The patient records were screened to determine whether patients received a periodontal diagnosis, whether the diagnosis followed the 2018 AAP Classification Guidelines, and if appropriate preventive and therapeutic procedures were completed in a timely manner. In addition, the type or year of dental student providing the procedure was also recorded. Data were analysed using descriptive statistics and a Chi‐squared test.ResultsA total of 612 charts were generated for review and 157 met the inclusion criteria and were evaluated. Results revealed that more than half (56.7%) of the patient records did not demonstrate a periodontal diagnosis and another 10.8% did not follow current AAP Classification Guidelines. Most patients (n = 125, 79.6%) had a comprehensive periodontal assessment performed, while 32 (20.4%) had no comprehensive periodontal charting information recorded. Further, of the 157 records reviewed, 96 (61.1%) had no periodontal treatment specified. A statistically significant difference with a modest association was found between type of dental student and year based on periodontal diagnosis (Fisher's exact test value = 20.72, p = .001, Cramer's V = 0.25).ConclusionDocumentation of key clinical information, diagnostic conclusions, and treatment rendered requires curriculum review. Further studies are warranted to determine whether similar findings exist among other dental school education programs.
Impact of public health and higher education policies on the profile of final‐year Brazilian dental students: Challenges and future developments
Authors: Bitencourt Fernando Valentim , Olsson Thaís Ostroski , Lamers Juliana Maciel de Souza , Leite Fabio Renato Manzolli , Nascimento Gustavo Giacomelli , Toassi Ramona Fernanda Ceriotti 
Published: July 2022

AbstractIntroductionBrazil has experienced transformations in higher education and health services, including launching more inclusive public policies focused on these two areas.ObjectiveTo evaluate the profile of final‐year dental students from a Brazilian public university from 2010 to 2019, accompanied by changes in public health and higher education policies.MethodsA prospective observacional study was carried out with final‐year dental students. A self‐applicable semi‐structured questionnaire was applied.ResultSix‐hundred and seventy‐seven students participated, of which 71.5% were women, 72.9% aged between 21 and 25 years, 96.2% single, and 96.4% were without children. Over ten years, it was possible to identify trends in the profile explained by implementing public policies toward more inclusive access to Brazilian higher education by socioeconomically disadvantaged individuals. Students who completed the course between 2018 and 2019 did not have the state capital city (the wealthiest area) as their origin city and had lower parental education and income levels than dental students graduating between 2010 and 2011. Moreover, working as a primary care dentist in the Brazilian National Health System was considered a professional possibility by 61.4% of the students, and has gained prominence significantly over time, ranging from 21.1% in 2010 to 72.9% in 2019 (p < .05).ConclusionOver the study period, concomitantly to advances in public health and higher education policies in Brazil, more diverse access to public dental education was observed, allowing students from low socioeconomic positions to take the education. Changes have also impacted the students' perspectives regarding the need for postgraduate training and a career in public health dentistry. However, these trends need to be consolidated, and public policies continued and strengthened.
Doctoral education from its medieval foundations to today's globalisation and standardisation
Authors: Ruano‐Borbalan Jean‐Claude 
Published: July 2022

AbstractThe doctorate, as a ritualised form of evaluation, has existed for more than eight centuries—initially linked to Western medieval forms of knowledge production framed by religion, and to the professional training of lawyers and doctors. It nearly disappeared at the end of the modern era. Recast as a requirement for academic professions, it proceeded to play an important role in the production of new knowledge and became a key to scientific and research development in the 19th and 20th centuries. Since less than half a century ago, doctoral education has gone through tremendous changes due to both the globalisation and standardisation of higher education and public policies designed to encourage knowledge transfers from academia to society at large. Doctoral education has become a crucial part of knowledge production and the transfer of knowledge into the broader economy, but it faces huge obstacles that can only be understood by taking into account the history of its transformations, the anthropological role it played and still plays, and also the controversial effect of efforts to standardise knowledge production, which goes against the non‐standard nature of human knowledge creation.