bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic morphologies of submerged late glacial to Early Holocene landscapes at the eastern Dogger Bank, central North Sea Basin – implications for geo-archaeological potential
Authors: Andresen Katrine Juul , Hepp Daniel A. , Keil Hanno , Spiess Volkhard 
Published: March 2022

Abstract
The inundated Doggerland in the North Sea Basin has been a coveted research target for many years owing to its key location with respect to geological evolution since the last glaciation and its archaeological potential related to prehistoric hunter–gatherer populations. Still, many uncertainties related to glacial and sea-level forcing on erosion and deposition remain, and the first discovery of submerged settlements is yet to be reported. In this study, we present a range of seismic morphologies and facies characteristic for the late glacial and Holocene succession near a major drainage system at the eastern Dogger Bank. Five of these facies are dominant in the area while two facies can be associated with a terrestrial–fluvial landscape buried 0–22 m below the seafloor. We detect various erosion levels of the terrestrial–fluvial landscape that are greatest towards the south where sediment has been removed, probably owing to combined terrestrial–fluvial and marine erosion. We find that five subareas show geo-archaeological potential in terms of (1) the preservation degree of terrestrial strata based on erosion estimates, (2) the accessibility of terrestrial strata based on burial depths and (3) the palaeolandscape configuration based on the spatial setting in relation to the drainage system and the palaeocoastlines. We further document a geological evolution of the study area, which is comparable with the evolution at the western Dogger Bank. However, we find more evidence for an extended flooding period because of the vicinity to the major drainage system and the Elbe Paleo Valley. We propose that our approach can be used as a workflow for marine investigations that focus on submerged hunter–gatherer heritage.
Cardiac Dysfunction Promotes Cancer Progression via Multiple Secreted Factors
Authors: Awwad Lama , Aronheim Ami 
Published: March 2022

Abstract

Heart failure and cancer are the leading cause of deaths worldwide. While heart failure and cancer have been considered separate diseases, it is becoming evident that they are highly connected and affect each other's outcomes. Recent studies using experimental mouse models have suggested that heart failure promotes tumor progression. The mouse models used involve major irreversible surgery. Here, we induced heart hypertrophy via expression of activating transcription factor 3 (ATF3) in cardiomyocytes, followed by cancer cells’ implantation. Tumors developing in ATF3-transgenic mice grew larger and displayed a more highly metastatic phenotype compared with tumors in wild-type mice. To address whether ATF3 expression or the cardiac outcome are necessary for tumor progression, ATF3 expression was turned off after cardiac hypertrophy development followed by cancer cell implantation. The tumor promotion phenotype and the enhancement of metastatic properties were preserved, suggesting that the failing heart per se is sufficient to promote tumor progression. Serum derived from ATF3-transgenic mice enhanced cancer cell proliferation and increased cancer cell metastatic properties in vitro. Using a cytokine array panel, multiple factors responsible for promoting tumor cell proliferation and the metastatic phenotype were identified. Interestingly, the failing heart and the tumor separately and simultaneously contributed to higher levels of these factors in the serum as well as other tissues and organs. These data suggest the existence of intimate cross-talk between the hypertrophied heart and the tumor that is mediated by secreted factors, leading to cancer promotion and disease deterioration.

Significance:
This work highlights the importance of early diagnosis and treatment of heart failure prior to reaching the irreversible stage that can exacerbate cancer progression.
Patients Recently Treated for B-lymphoid Malignancies Show Increased Risk of Severe COVID-19
Authors: Rubinstein Samuel M. , Bhutani Divaya , Lynch Ryan C. , Hsu Chih-Yuan , Shyr Yu , Advani Shailesh , Mesa Ruben A. , Mishra Sanjay , Mundt Daniel P. , Shah Dimpy P. , Sica R. Alejandro , Stockerl-Goldstein Keith E. , Stratton Catherine , Weiss Matthias , Beeghly-Fadiel Alicia , Accordino Melissa , Assouline Sarit E. , Awosika Joy , Bakouny Ziad , Bashir Babar , Berg Stephanie , Bilen Mehmet Asim , Castellano Cecilia A. , Cogan Jacob C. , KC Devendra , Friese Christopher R. , Gupta Shilpa , Hausrath Daniel , Hwang Clara , Johnson Nathalie A. , Joshi Monika , Kasi Anup , Klein Elizabeth J. , Koshkin Vadim S. , Kuderer Nicole M. , Kwon Daniel H. , Labaki Chris , Latif Tahir , Lau Eric , Li Xuanyi , Lyman Gary H. , McKay Rana R. , Nagaraj Gayathri , Nizam Amanda , Nonato Taylor K. , Olszewski Adam J. , Polimera Hyma V. , Portuguese Andrew J. , Puc Matthew M. , Razavi Pedram , Rosovski Rachel , Schmidt Andrew , Shah Sumit A. , Shastri Aditi , Su Christopher , Torka Pallawi , Wise-Draper Trisha M. , Zubiri Leyre , Warner Jeremy L. , Thompson Michael A. ,   for the COVID-19 and Cancer Consortium
Published: March 2022

Abstract

Patients with B-lymphoid malignancies have been consistently identified as a population at high risk of severe COVID-19. Whether this is exclusively due to cancer-related deficits in humoral and cellular immunity, or whether risk of severe COVID-19 is increased by anticancer therapy, is uncertain. Using data derived from the COVID-19 and Cancer Consortium (CCC19), we show that patients treated for B-lymphoid malignancies have an increased risk of severe COVID-19 compared with control populations of patients with non–B-lymphoid malignancies. Among patients with B-lymphoid malignancies, those who received anticancer therapy within 12 months of COVID-19 diagnosis experienced increased COVID-19 severity compared with patients with non–recently treated B-lymphoid malignancies, after adjustment for cancer status and several other prognostic factors. Our findings suggest that patients recently treated for a B-lymphoid malignancy are at uniquely high risk for severe COVID-19.

Significance:
Our study suggests that recent therapy for a B-lymphoid malignancy is an independent risk factor for COVID-19 severity. These findings provide rationale to develop mitigation strategies targeted at the uniquely high-risk population of patients with recently treated B-lymphoid malignancies.
This article is highlighted in the In This Issue feature, p. 171
Exercícios passivos na reabilitação de pacientes com dor, edema e limitação articular: estudo piloto
Authors: Folchine Ana Elisa Rosselli , Foss Marco Henrique Dall’aglio , Cavenaghi Simone , Godoy Jose Maria Pereira de 
Published: March 2022

Imobilização parcial ou completa leva a diferentes processos de ajuste como perda de força muscular, diminuição do desempenho geral e edema. Objetivo: Avaliar a melhora da dor utilizando de um dispositivo eletromecânico que realiza movimentos passivo nos pacientes com dor, limitação da mobilidade e uso de dispositivos auxiliadores da marcha. Método: Foram avaliados em ensaio clinico prospectivo 20 pacientes, a melhora da dor, fazendo uso de dispositivos auxiliares de locomoção, em pacientes que faziam tratamento convencional por quatro a 12 meses, mas que passaram a fazer diariamente por uma hora e, comparando com exercício passivo realizado com o dispositivo, por duas horas/dia, por cinco dias, e avaliados pela escala analógica de dor antes e depois no Hospital de Base da Fundação Faculdade de Medicina de São Jose do Rio Preto - FUNFARME de março de 2019 a janeiro de 2020. Resultados: Quando compara a diferença de redução do grupo realizou dispositivo eletromecânico passivo com o grupo convencional houve uma redução de 6,6 na escala analógica de dor e em relação ao grupo convencional de 2, sendo diferente estatisticamente teste t pareado valor p= 0,0001. Conclusão: Exercícios passivos mecânicos, que realizam a drenagem linfática é uma nova opção de tratamento aos pacientes que tem dor e limitação crônica da marcha.
Dialysis Initiation in Patients With Chronic Coronary Disease and Advanced Chronic Kidney Disease in ISCHEMIA‐CKD
Authors: Briguori Carlo , Mathew Roy O. , Huang Zhen , Mavromatis Kreton , Hickson LaTonya J. , Lau Wei Ling , Mathew Anoop , Mahajan Sandeep , Wheeler David C. , Claes Kathleen J. , Chen Gang , Nolasco Fernando E. B. , Stone Gregg W. , Fleg Jerome L. , Sidhu Mandeep S. , Rockhold Frank W. , Chertow Glenn M. , Hochman Judith S. , Maron David J. , Bangalore Sripal 
Published: March 2022

Background
In participants with concomitant chronic coronary disease and advanced chronic kidney disease (CKD), the effect of treatment strategies on the timing of dialysis initiation is not well characterized.

Methods and Results

In ISCHEMIA‐CKD (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches–Chronic Kidney Disease), 777 participants with advanced CKD and moderate or severe ischemia were randomized to either an initial invasive or conservative management strategy. Herein, we compare the proportion of randomized participants with non–dialysis‐requiring CKD at baseline (n=362) who initiated dialysis and compare the time to dialysis initiation between invasive versus conservative management arms. Using multivariable Cox regression analysis, we also sought to identify the effect of invasive versus conservative chronic coronary disease management strategies on dialysis initiation. At a median follow‐up of 23 months (25th–75th interquartile range, 14–32 months), dialysis was initiated in 18.9% of participants (36/190) in the invasive strategy and 16.9% of participants (29/172) in the conservative strategy
(P=
0.22). The median time to dialysis initiation was 6.0 months (interquartile range, 3.0–16.0 months) in the invasive group and 18.2 months (interquartile range, 12.2–25.0 months) in the conservative group
(P=
0.004), with no difference in procedural acute kidney injury rates between the groups (7.8% versus 5.4%;
P
=0.26). Baseline clinical factors associated with earlier dialysis initiation were lower baseline estimated glomerular filtration rate (hazard ratio [HR] associated with 5‐unit decrease, 2.08 [95% CI, 1.72–2.56];
P
<0.001), diabetes (HR, 2.30 [95% CI, 1.28–4.13];
P
=0.005), hypertension (HR, 7.97 [95% CI, 1.09–58.21];
P
=0.041), and Hispanic ethnicity (HR, 2.34 [95% CI, 1.22–4.47];
P
=0.010).

Conclusions
In participants with non–dialysis‐requiring CKD in ISCHEMIA‐CKD, randomization to an invasive chronic coronary disease management strategy (relative to a conservative chronic coronary disease management strategy) is associated with an accelerated time to initiation of maintenance dialysis for kidney failure.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01985360.
Evolution of Neuropsychological Deficits in First-Ever Isolated Ischemic Thalamic Stroke and Their Association With Stroke Topography: A Case-Control Study
Authors: Scharf Anne-Carina , Gronewold Janine , Todica Olga , Moenninghoff Christoph , Doeppner Thorsten R. , de Haan Bianca , Bassetti Claudio L.A. , Hermann Dirk M. 
Published: March 2022

Background:
The thalamus plays an essential role in cognition. Cognitive deficits have to date mostly been studied retrospectively in chronic thalamic stroke in small cohorts. Studies prospectively evaluating the evolution of cognitive deficits and their association with thalamic stroke topography are lacking. This knowledge is relevant for targeted patient diagnostics and rehabilitation.

Methods:
Thirty-seven patients (57.5±17.5 [mean±SD] years, 57% men) with first-ever acute isolated ischemic stroke covering the anterior (n=5), paramedian (n=12), or inferolateral (n=20) thalamus and 37 in-patient controls without stroke with similar vascular risk factors matched for age and sex were prospectively studied. Cognition was evaluated using predefined tests at 1, 6, 12, and 24 months. Voxel-based lesion-symptom mapping was used to determine associations between neuropsychological deficits and stroke topography.

Results:
Patients with anterior thalamic stroke revealed severe deficits in verbal memory (median T score [Q1–Q3]: 39.1 [36.1–44.1]), language (31.8 [31.0–43.8]), and executive functions (43.8 [35.5–48.1]) at 1 month compared with controls (verbal memory: 48.5 [43.6–61.0], language: 55.7 [42.3–61.1], executive functions: 51.3 [50.1–56.8]). Patients with paramedian thalamic stroke showed moderate language (44.7 [42.8–55.9]) and executive (49.5 [44.3–55.1]) deficits and no verbal memory deficits (48.1 [42.5–54.7]) at 1 month compared with controls (59.0 [47.0–64.5]; 59.6 [51.1–61.3]; 52.5 [44.2–55.3]). The language and executive deficits in paramedian thalamic stroke patients almost completely recovered during follow-up. Intriguingly, significant deficits in verbal memory (44.7 [41.5–51.9]), language (47.5 [41.8–54.1]), and executive functions (48.2 [46.2–59.7]) were found in inferolateral thalamic stroke patients at 1 month compared with controls (50.5 [46.7–59.9]; 57.0 [51.2–62.9]; 57.4 [51.2–60.7]). Language, but not executive deficits persisted during follow-up. Voxel-based lesion-symptom mapping revealed an association of verbal memory deficits with anterior thalamus lesions and an association of non-verbal memory, language, and executive deficits with lesions at the anterior/paramedian/inferolateral border.

Conclusions:
All 3 stroke topographies exhibited significant deficits in diverse cognitive domains, which recovered to a different degree depending on the stroke localization. Our study emphasizes the need for comprehensive neuropsychological diagnostics to secure adequate patient rehabilitation.
Integrating Cultural Heritage into Human Security Analysis
Authors: Weinert Matthew S. 
Published: March 2022

Abstract
The UN Development Programme introduced the human security concept in 1994 to address the diversity of challenges to people’s survival, livelihood, and dignity in seven key areas: personal, food, health, economic, political, community, and environmental security. A voluminous literature has since engaged its definitional parameters, theoretical implications, and practical applications. Yet neither dignity nor community security, defined in part to include cultural traditions and identities, have attracted much attention despite considerable human and community insecurities caused by assaults on cultural heritage which, as emblematic of distinctive cultural identities, have downward effects on dignity. This article aims to correct that gap. It identifies and examines three security markers to ascertain and redress the sufferance of indignities and insecurities pertaining to heritage, dignity, and community security: ensuring use of heritage; promoting its transmission; and protecting and advancing cultural rights.
Influence of Tactile Flow on Visual Heading Perception
Authors: Rosenblum Lisa , Grewe Elisa , Churan Jan , Bremmer Frank 
Published: March 2022

Abstract
The integration of information from different sensory modalities is crucial for successful navigation through an environment. Among others, self-motion induces distinct optic flow patterns on the retina, vestibular signals and tactile flow, which contribute to determine traveled distance (path integration) or movement direction (heading). While the processing of combined visual–vestibular information is subject to a growing body of literature, the processing of visuo-tactile signals in the context of self-motion has received comparatively little attention. Here, we investigated whether visual heading perception is influenced by behaviorally irrelevant tactile flow. In the visual modality, we simulated an observer’s self-motion across a horizontal ground plane (optic flow). Tactile self-motion stimuli were delivered by air flow from head-mounted nozzles (tactile flow). In blocks of trials, we presented only visual or tactile stimuli and subjects had to report their perceived heading. In another block of trials, tactile and visual stimuli were presented simultaneously, with the tactile flow within ±40° of the visual heading (bimodal condition). Here, importantly, participants had to report their perceived visual heading. Perceived self-motion direction in all conditions revealed a centripetal bias, i.e., heading directions were perceived as compressed toward straight ahead. In the bimodal condition, we found a small but systematic influence of task-irrelevant tactile flow on visually perceived headings as function of their directional offset. We conclude that tactile flow is more tightly linked to self-motion perception than previously thought.
Phylum Nematoda: a classification, catalogue and index of valid genera, with a census of valid species
Authors: HODDA M. 
Published: March 2022

A classification of the entire Phylum Nematoda is presented, based on current molecular, developmental and morphological evidence. The classification reflects the evolutionary relationships within the phylum, as well as significant areas of uncertainty, particularly related to the early evolution of nematodes. It includes 3 classes, 8 subclasses, 12 superorders, 32 orders, 53 suborders, 101 superfamilies, 276 families, 511 subfamilies, 3030 genera, and 28537 species. All valid species named from the time of publication of the previous classification and census (2010) to the end of 2019 are listed, along with the number of valid species in each genus. Taxonomic authorities are provided for taxon names of all ranks. The habitats where the species in each genus are found are listed, and an alphabetic index of genus names is provided. The systematics of nematodes is reviewed, along with a history of nematode classification; evolutionary affinities and origins of nematodes; and the current diagnosis of the group. Short overviews of the general biology, ecology, scientific and economic importance of the group are presented.
High Ice Water Content Conditions Associated with Wintertime Elevated Convection in the Midwest
Authors: Rugg Allyson , Bernstein Ben C. , Haggerty Julie A. , Korolev Alexei , Nguyen Cuong , Wolde Mengistu , Heckman Ivan , DiVito Stephanie 
Published: March 2022

AbstractAircraft flying through areas of high ice water content (HIWC) can experience engine damage and/or failure. HIWC is typically associated with convection and the microphysical properties of tropical oceanic and coastal convection are well documented as a result of several field campaigns in the past decade. HIWC appears to be less common in extratropical convection, but instances of HIWC-related aircraft issues have been recorded in extratropical weather, even during winter. The present study documents the microphysical properties of HIWC between −25° and 0°C and the meteorological and thermodynamic conditions around that HIWC from five flights from the In-Cloud Icing and Large-Drop Experiment (ICICLE) in the midwestern United States in February 2019. All five cases contained elevated convection above a strong low-level temperature inversion. Values for top-of-inversion mixing ratios and total column precipitable water were about 5 g kg−1and 20 mm, respectively, according to soundings near each case. A maximum ice water content of 2.1 g m−3was observed over a length scale of about 500 m, and ice particle size distributions had mean volume equivalent diameters around 1000μm. Supercooled drizzle droplets were also observed in the vicinity of the HIWC, raising questions about the possible role of secondary ice production via the freezing and shattering of supercooled large droplets in HIWC formation. The generalizability of these results is limited by the small number of cases, but they provide some of the first in situ observations of extratropical winter HIWC and highlight the need for continued research on these conditions.Significance StatementHigh ice water content (HIWC) conditions can cause engine damage, stall, and failure in aircraft and can cause air data probes to report erroneous values. Most research on HIWC has focused on tropical convection. This paper serves to draw more attention to the aviation hazard posed by extratropical winter HIWC and the need for additional research into these environments. The cases examined also contained supercooled precipitation-sized liquid droplets. Combined with other recent research, these observations may help to motivate laboratory experiments investigating the role of secondary ice production via droplet freezing and shattering in the formation of HIWC.
Soluble Vascular Adhesion Protein-1 Level Correlates With Adropin and Inflammatory Biomarkers in Patients With Obstructive Sleep Apnea
Authors: Kong Zhongyu , Liu Yuehong 
Published: March 2022

Purpose Soluble vascular adhesion protein-1 (sVAP-1) and adropin are 2 biomarkers of endothelial dysfunction. The main purpose of this study was to evaluate the levels of sVAP-1 in patients with moderate and severe obstructive sleep apnea (OSA) compared to healthy controls, and to further determine the relationship between sVAP-1 and adropin levels, as well as inflammatory biomarkers and sleep parameters. Methods In this study, we included 50 male patients with OSA (25 moderate and 25 severe) and 20 age- and sex-matched control subjects. Patients with OSA underwent polysomnography. All subjects underwent fasting peripheral blood sampling for laboratory analysis. Results Serum sVAP-1 and inflammatory biomarkers (IL-6, TNF-α, and hsCRP) levels were significantly higher in patients with severe OSA compared to those with moderate OSA and control groups, while plasma levels of adropin showed the opposite trend. Furthermore, sVAP-1 levels had a significant positive correlation with AHI, ODI, TNF-α, IL-6, and hsCRP levels and a significant negative correlation with adropin levels. The receiver operating characteristic analysis showed an Area Under Curve (AUC) of .876 ( P < .001) for sVAP-1 levels predicting OSA. Serum sVAP-1 threshold of > 445.5 ng/mL had an 88% sensitivity and 80% specificity for detecting OSA status. Multivariate regression analysis demonstrated that sVAP-1 remained a significant positive predictor of OSA severity. Conclusions Increased sVAP-1 levels in OSA patients are significantly correlated with indices of OSA severity, adropin levels, and inflammatory biomarkers, suggesting that sVAP-1 plays a vital role in the pathophysiology of OSA and may become a potential screening tool in the evaluation of OSA severity.
Perspectives and early experience on endoscopic stapedotomy from a group of “traditional school” otologists
Authors: Dutta Mainak , Kundu Sohag , Ghosh Bhaskar , Ghosh Pramit 
Published: March 2022

Background: This paper evaluates endoscopic stapedotomy from the perspectives of a group of 3 surgeons, each of whose experience in endoscopic and microscopic stapedotomy is 3 years and more than 12 years, respectively. Methods: Thirty-four patients clinically diagnosed with stapedial otosclerosis were alternately assigned for unilateral, microscope- and endoscope-assisted stapedotomy following the selection criteria given. Results were evaluated with predetermined epidemiologic, preoperative, perioperative, and postoperative outcome parameters. Results: The microscope group had 12 ears with otosclerosis and the endoscope-assisted group 14. Ears found to have conditions other than otosclerosis at surgery, and patients lost to follow-up were excluded. Apart from the operative time, the difference in the results of none of the parameters was statistically significant in the two groups. The average operative times for microscope- and endoscope-assisted stapedotomy were 63 minutes and 86.5 minutes, respectively, the difference being statistically significant ( P < .001). Conclusions: From the perspectives of otologists in differential positions in the learning curve for microscope- and endoscope-assisted stapedotomy, there were no statistically significant differences between the two procedures in the execution of the steps to achieve “adequate surgical exposure” and in postoperative outcomes, except for operative time.