bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heat-labile enterotoxin enhances F4-producing enterotoxigenic E. coli adhesion to porcine intestinal epithelial cells by upregulating bacterial adhesins and STb enterotoxin
Authors: Duan Qiangde , Pang Shengmei , Feng Lili , Liu Jiaqi , Lv Linfen , Li Baoliang , Liang Yuxuan , Zhu Guoqiang 
Published: October 2022

AbstractAs one of the crucial enterotoxins secreted by enterotoxigenic Escherichia coli (ETEC), heat-labile enterotoxin (LT) enhances bacterial adherence both in vivo and in vitro; however, the underlying mechanism remains unclear. To address this, we evaluated the adherence of LT-producing and LT-deficient ETEC strains using the IPEC-J2 cell model. The expression levels of inflammatory cytokines and chemokines, and tight-junction proteins were evaluated in IPEC-J2 cells after infection with various ETEC strains. Further, the levels of adhesins and enterotoxins were also evaluated in F4ac-producing ETEC (F4 + ETEC) strains after treatment with cyclic AMP (cAMP). The adherence of the ΔeltAB mutant was decreased compared with the wild-type strain, whereas adherence of the 1836-2/pBR322-eltAB strain was markedly increased compared with the 1836-2 parental strain. Production of LT up-regulated the expression of TNF-α, IL-6, CXCL-8, and IL-10 genes. However, it did not appear to affect tight junction protein expression. Importantly, we found that cAMP leads to the upregulation of adhesin production and STb enterotoxin. Moreover, the F4 + ETEC strains treated with cAMP also had greater adhesion to IPEC-J2 cells, and the adherence of ΔfaeG, ΔfliC, and ΔestB mutants was decreased. These results indicate that LT enhances the adherence of F4 + ETEC due primarily to the upregulation of F4 fimbriae, flagellin, and STb enterotoxin expression and provide insights into the pathogenic mechanism of LT and ETEC.
On the class of uncertainty inequalities for the coupled fractional Fourier transform
Authors: Shah Firdous A. , Lone Waseem Z. , Nisar Kottakkaran Sooppy , Abdeljawad Thabet 
Published: October 2022

AbstractThe coupled fractional Fourier transform$\mathcal {F}_{\alpha ,\beta}$Fα,βis a two-dimensional fractional Fourier transform depending on two anglesαandβ, which are coupled in such a way that the transform parameters are$\gamma =(\alpha +\beta )/2$γ=(α+β)/2and$\delta =(\alpha -\beta )/2$δ=(α−β)/2. It generalizes the two-dimensional Fourier transform and serves as a prominent tool in some applications of signal and image processing. In this article, we formulate a new class of uncertainty inequalities for the coupled fractional Fourier transform (CFrFT). Firstly, we establish a sharp Heisenberg-type uncertainty inequality for the CFrFT and then formulate some logarithmic and local-type uncertainty inequalities. In the sequel, we establish several concentration-based uncertainty inequalities, including Nazarov, Amrein–Berthier–Benedicks, and Donoho–Stark’s inequalities. Towards the end, we formulate Hardy’s and Beurling’s inequalities for the CFrFT.
Energy-efficient allocation for multiple tasks in mobile edge computing
Authors: Liu Jun , Liu Xi 
Published: October 2022

AbstractMobile edge computing (MEC) allows a mobile device to offload tasks to the nearby server for remote execution to enhance the performance of user equipment. A major challenge of MEC is to design an efficient algorithm for task allocation. In contrast to previous work on MEC, which mainly focuses on single-task allocation for a mobile device with only one task to be completed, this paper considers a mobile device with multiple tasks or an application with multiple tasks. This assumption does not hold in real settings because a mobile device may have multiple tasks waiting to execute. We address the problem of task allocation with minimum total energy consumption considering multi-task settings in MEC, in which a mobile device has one or more tasks. We consider the binary computation offloading mode and formulate multi-task allocation as an integer programming problem that is strongly NP-hard. We propose an approximation algorithm and show it is a polynomial-time approximation scheme that saves the maximum energy. Therefore, our proposed algorithm achieves a tradeoff between optimality loss and time complexity. We analyze the performance of the proposed algorithm by performing extensive experiments. The results of the experiments demonstrate that our proposed approximation algorithm is capable of finding near-optimal solutions, and achieves a good balance of speed and quality.
The correlation between anxiety, depression, and vertigo: a cross-sectional study
Authors: Omara Abir , Basiouny Eman Mostafa , Shabrawy Marwa El , Shafei Reham Rafei El 
Published: October 2022

Abstract
Background
Dizziness, including vertigo, affects approximately 15% to over 20% of adults each year. A significant proportion of patients with vertigo develop secondary psychiatric disorders throughout their disease. On the other hand, patients with psychiatric disorders frequently report dizziness as a co-occurring symptom of their illness. The purpose of this study was to screen the prevalence of depression and anxiety indices in dizzy patients and their relation to the severity of their dizziness handicap by administering two different questionnaires: The dizziness handicap inventory (DHI) and the Hospital Anxiety and Depression Scale (HADS).

Results
Psychological assessments revealed that 49% of the study group was normal, 29% had anxiety, 7% had depression, and 15% had both anxiety and depression. Besides, vestibular neuritis was associated with a higher mean anxiety score, whereas Meniere's disease was associated with a higher mean depression score.

Conclusion
As this study has shown, there was a statistically significant positive correlation between anxiety and depression scores and physical, emotional, functional, and total DHI scores. Screening and treatment of co-morbid mental health disorders are critical for appropriate management of vertigo disability that leads to a higher quality of life and fewer complications.
An ab initio study on phase stability, elastic and mechanical properties of Zr-doped TiAl2 and α-TiAl3 intermetallics
Authors: Mermer Erdem , Çinici Hanifi , Uğur Gökay , Ünal Rahmi 
Published: October 2022

Abstract
In this study, phase stability, elastic and mechanical properties of Zr-doped TiAl2 and

intermetallics have been studied by ab initio calculations based on density functional theory. The virtual crystal approximation (VCA) method has been utilized to develop crystal structures. Calculated lattice constants and elastic properties of the unalloyed TiAl2 and

intermetallics were given and discussed. In addition, machinability index has been accounted for. Formation enthalpies, Gibbs free energies of Zr-doped compounds are lower than pure TiAl2 and

intermetallics. Bulk moduli values have been improved by Zr doping for both alloys. Ductile alloys have been obtained when Zr addition of TiAl2 and

was greater than 6.0 wt.%.
Teprotumumab-Related Hyperglycemia
Authors: Amarikwa Linus , Mohamed Abubakr , Kim Sun H , Kossler Andrea Lora , Dosiou Chrysoula 
Published: October 2022

Abstract

Context
Graves orbitopathy (GO) or thyroid eye disease is a potentially sight-threatening and disfiguring autoimmune disease. Teprotumumab is a monoclonal antibody against the insulin-like growth factor-I receptor that was recently approved for GO treatment. Hyperglycemia is a recognized adverse event of teprotumumab, occurring in 10% of patients in 2 recent randomized controlled trials.

Objective
Our study aimed to report the incidence, severity, management, and longitudinal glycemic changes in patients treated with teprotumumab in an academic practice cohort.

Methods
This longitudinal, observational study included all consecutive patients treated with teprotumumab between March 2020 and May 2022 at 1 institution. Hemoglobin A1c (HbA1c) was measured every 3 months.

Results
Forty-two patients with baseline normoglycemia (n = 22), prediabetes (n = 10), and diabetes (n = 10) were followed for a mean of 47.5 weeks. Overall, HbA1c increased by 0.5% at 3 months. Least-squares mean changes in HbA1c at 3 months were 1.3 (P &lt; .001), 0.7 (P = .01), and 0.1 (P = .41) in patients with diabetes, prediabetes, and normoglycemia, respectively. Twenty-two patients (52%) had hyperglycemia, which was graded as mild, moderate, and life-threatening in 55% (12/22), 41% (9/22), and 5% (1/22) of cases, respectively. Age, pre-existing diabetes, and Hispanic and Asian race/ethnicity were significant risk factors for hyperglycemia. Among patients with hyperglycemia, 36.4% (8/22) returned to baseline glycemic status at last follow-up.

Conclusion
While effective, teprotumumab carries a significant risk of hyperglycemia, especially in patients with diabetes. Hyperglycemia may persist after stopping teprotumumab. These findings underscore the importance of guidelines for screening and management of teprotumumab-related hyperglycemia.
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia
Authors: Toledo Rodrigo A , Jimenez Camilo , Armaiz-Pena Gustavo , Arenillas Carlota , Capdevila Jaume , Dahia Patricia L M 
Published: October 2022

Abstract
Tumors driven by deficiency of the VHL gene product, which is involved in degradation of the hypoxia-inducible factor subunit 2 alpha (HIF2α), are natural candidates for targeted inhibition of this pathway. Belzutifan, a highly specific and well-tolerated HIF2α inhibitor, recently received FDA approval for the treatment of nonmetastatic renal cell carcinomas, pancreatic neuroendocrine tumors, and central nervous system hemangioblastomas from patients with von Hippel–Lindau disease, who carry VHL germline mutations. Such approval is a milestone in oncology; however, the full potential, and limitations, of HIF2α inhibition in the clinic are just starting to be explored. Here we briefly recapitulate the molecular rationale for HIF2α blockade in tumors and review available preclinical and clinical data, elaborating on mutations that might be particularly sensitive to this approach. We also outline some emerging mechanisms of intrinsic and acquired resistance to HIF2α inhibitors, including acquired mutations of the gatekeeper pocket of HIF2α and its interacting partner ARNT. Lastly, we propose that the high efficacy of belzutifan observed in tumors with genetically driven hypoxia caused by VHL mutations suggests that a focus on other mutations that similarly lead to HIF2α stabilization, such as those occurring in neuroendocrine tumors with disruptions in the tricarboxylic acid cycle (SDHA/B/C/D, FH, MDH2, IDH2), HIF hydroxylases (EGLN/PHDs), and the HIF2α-encoding gene, EPAS1, are warranted.
In toto imaging of early enteric nervous system development reveals that gut colonization is tied to proliferation downstream of Ret
Authors: Baker Phillip A. , Ibarra-García-Padilla Rodrigo , Venkatesh Akshaya , Singleton Eileen W. , Uribe Rosa. A. 
Published: October 2022

ABSTRACT
The enteric nervous system is a vast intrinsic network of neurons and glia within the gastrointestinal tract and is largely derived from enteric neural crest cells (ENCCs) that emigrate into the gut during vertebrate embryonic development. Study of ENCC migration dynamics and their genetic regulators provides great insights into fundamentals of collective cell migration and nervous system formation, and these are pertinent subjects for study due to their relevance to the human congenital disease Hirschsprung disease (HSCR). For the first time, we performed in toto gut imaging and single-cell generation tracing of ENCC migration in wild type and a novel ret heterozygous background zebrafish (retwmr1/+) to gain insight into ENCC dynamics in vivo. We observed that retwmr1/+ zebrafish produced fewer ENCCs localized along the gut, and these ENCCs failed to reach the hindgut, resulting in HSCR-like phenotypes. Specifically, we observed a proliferation-dependent migration mechanism, where cell divisions were associated with inter-cell distances and migration speed. Lastly, we detected a premature neuronal differentiation gene expression signature in retwmr1/+ ENCCs. These results suggest that Ret signaling may regulate maintenance of a stem state in ENCCs.
Experimental Determination of Deviation from Spherical Electron Densities of Atoms in Benzene Molecules in the Liquid State
Authors: Kameda Yasuo , Kowaguchi Misaki , Amo Yuko , Usuki Takeshi , Okuyama Daisuke , Sato Taku J 
Published: October 2022

Abstract
Deviation of electron distribution around atomic nuclei from the spherical density in liquid benzene has directly been obtained through a X-ray–neutron difference interference function derived from the difference between the intermolecular X-ray diffraction interference term and the linear combination of neutron intermolecular partial structure factors weighted by atomic scattering factors for the X-ray scattering. The difference distribution function exhibits a broad negative peak at around r = 3.24 Å corresponding to intermolecular distance in which electron density is relatively lower than that for the spherical case. Positive peaks found at r = 4.30, 5.22, and 6.20 Å indicate intermolecular distances with higher electron density. This experimental evidence for intermolecular electron distribution in the liquid benzene has been discussed by means of the average molecular geometry of the nearest neighbor benzene molecules which was determined from the least squares analyses of observed neutron intermolecular partial structure factors.
Daily Stress and Microvascular Dysfunction: The Buffering Effect of Physical Activity
Authors: Greaney Jody L. , Darling Ashley M. , Saunders Erika F.H. , Almeida David M. 
Published: October 2022

ABSTRACT
Though often short-lived, emotional responsiveness to daily stressors (i.e., routine and sometimes unexpected everyday hassles) is associated with increased cardiovascular disease (CVD) morbidity and mortality. Here, we present the novel hypothesis that a disruption of microvascular homeostasis is a key antecedent. We additionally postulate that physical activity may mitigate the psychobiological consequences of daily stress, thereby limiting pathophysiological CVD-related sequelae.
Suicide in the geriatric population of South East Asia - contexts and attributes
Authors: Kar Sujita Kumar , Arafat S. M. Yasir , Pandey Nisha Mani , Kabir Russell , Singh Shivangini 
Published: October 2022

Suicide in the geriatric population is a significant problem. Increasing age, living alone, having a psychiatric illness and medical comorbidities have been identified as risk factors for suicide among the elderly population. The elderly population in South East Asia is rapidly growing and the number of elderly people with mental illness and/or medical comorbidities is also increasing. The factors and attributes of suicide may vary from region to region due to socio-cultural and geographic diversities. Understanding these factors may help in planning suicide prevention strategies for the elderly population. There is a dearth of studies assessing the demography, risk factors for, and prevention of suicide among the elderly population in South East Asia. We tried to observe and explain the challenging paradigms to excerpt attributes and the context of geriatric suicide. It is observed in this review that lack of social integration or interaction along with some psychiatric disorders leads to suicidal ideation and completed suicide in the elderly. South East Asia has unique characteristics in several aspects like religious and cultural diversity, poverty, unemployment, demographic structure of the region, migration, natural disasters and calamities, political environment, poor policy implementation, and easy access to suicide means (e.g. pesticides). Primary care physicians, specialized mental health support, gate-keeper training, means restriction, raising awareness, supportive family environment, and dedicated call centers could be potential areas for suicide prevention among the elderly people of the region. Further studies are warranted to formulate effective suicide prevention strategies.
Linguistic ecology and multilingual education
Authors: Brown Kara 
Published: October 2022

Einar Haugeni teedrajava keeleökoloogiat käsitleva teose viiekümnes aastapäev pakub ideaalset võimalust mõtiskleda mõnede uute paljutõotavate suundumuste üle hiljutistes mitmekeelset haridust puudutavates uurimustes, mis keskenduvad keeleökoloogiale. Siinses artiklis vaadeldud uurimustes proovitakse mitmesuguseid keelenähtusi mõista läbi keeleökoloogia prisma, lähtudes eelkõige dünaamilistest muutustest uuritava kogukonna sees. Artiklis keskendutakse keeleökoloogia uurimise kolmele viimase viieteist aasta jooksul väljakujunenud arengusuunale, mis näitavad, kuivõrd suur mõju ja tähendus on sellel raamistikul siiani mitmekeelsele haridusele: 1) keskendumine kõrgharidusele, 2) transkeelsus ning 3) keelelised õigused ja jätkusuutlikkus. Esimeses osas antakse ülevaade keeleökoloogia olemusest – selle terviklikkusest ja dünaamilisusest – ning keeleökoloogia uurimise põhimõtetest haridusvaldkonnas ja lõpetatakse võimalike tuleviku urimissuundadega.
Full text
Teachers’ perceptions of values-oriented dialogic communication in a multicultural learning environment
Authors: Nummert Mari-Liis , Harro-Loit Halliki , Parder Mari-Liisa 
Published: October 2022

See uurimus analüüsib Eesti õpetaja arusaamu väärtustele keskenduvast dialoogilisest kommunikatsioonist (VKDK) mitmekultuurilises õpikeskkonnas, keskendudes küsimusele, milliseid VKDK olukordi ja vajadusi märkavad mitmekultuurilise õpikeskkonna kogemusega õpetajad. Kultuuridevahelisi väärtusi puudutavad arutelud eeldavad vastastikust kuulamist ja mõistmist, mistõttu lähtub siinne uurimus teoreetiliselt dialoogilise kommunikatsiooni kontseptsioonist. Samast kontseptsioonist lähtub ka Tartu Ülikooli eetikakeskusese õpilaste mäng "Väärtuste avastajad", mille lisapakett on suunatud kultuuriliste väärtuste alaste arutelude algatamiseks ja juhtimiseks. Õpetajate arusaamu ja praktilisi kogemusi koguti poolstruktureeritud intervjuude kaudu. Valimi moodustavad üheksa TÜ eetikakeskuse ja Eesti Pagulasabi pagulus ja -rändeteemalises projektis osalenud õpetajat, kelle kogemuste refleksioon vaatleb nii VKDK praktikaid kui ka õpilaste mängu kasutamisel ilmnenud võimalusi ja piiranguid.
Summary
Spatial Perspectives on Adopting and Developing the Two-Way Immersion Program in Estonia’s Kindergartens: Resources & Risks
Authors: Brown Kara 
Published: October 2022

Etniline ja rassiline eraldatus on üsna levinud probleem mitmel pool maailmas ning liigagi sageli kohtame vastuseisu lõimumisele koolis. Seega väärivad sellisest suhtumisest erinevad juhtumid erilist tähelepanu, eriti olukordades, kus kogukonnad on elanud ranges eraldatuses juba mitmete põlvkondade vältel. Eestis, kus nõukogude ajajärgul ühiskonnas domineerinud venekeelne vähemus õppis harva ära kohaliku keele, pööras 1991. aasta taasiseseisvumine etnilise võimustruktuuri pahupidi ja asetas enamiku venekeelsetest elanikest olukorda, kus nende ainsa riigikeele – eesti keele – oskus oli kas vähene või olematu.
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Compiling a collection of reading texts for Estonian A2-level adults. Finding a balance between authenticity, interest and affordability
Authors: Kitsnik Mare , Palts Linda , Urb Monika 
Published: October 2022

Teise keele omandamise üheks peamiseks eeltingimuseks on autentse, huvipakkuva ja jõukohase keelelise sisendi saamine. Lisalugemine väljaspool keeletunde on hea võimalus sisendi mahtu suurendada, kuid täiskasvanud algtasemel eesti keele õppijail on keeruline leida endale jõukohaseid autentseid ja huvitavaid lisalugemistekste. Artiklis vaadeldakse magistritööna tehtud arendusuuringut, mille käigus valmis täiskasvanud A2-taseme keeleõppijate jaoks illustreeritud lugemistekstide kogumik. Uuringu esimeses etapis loodi päriselus juhtunud sündmuste põhjal 32 teksti. Teises etapis koguti tekstidele kolmekordne tagasiside: sihtrühmalt, õppekirjanduse eksperdilt ja EKI keeleanalüsaatori abil. Kolmandas etapis toimetati tekste tagasiside põhjal. Lõpptulemusena valmis autentselaadse sisu ja keelekasutusega, täiskasvanutele huvipakkuvate ning A2-tasemele jõukohaste tekstide kogumik "Meie elu" (Palts, Urb, 2020), milles on 32 blogisissekandestiilis teksti.
Summary
Features of EEG & HRV in 1997 in humans exposed to the factors of the accident at the Chornobylian nuclear power plant in 1986
Authors: Ruzhylo Sofiya , Zakalyak Nataliya , Ivanikiv Nataliya , Popovych Dariya , Żukow Xawery , Popovych Igor 
Published: October 2022

Background. The dramatic events of the Russian-Ukrainian war around the Chornobyl’ nuclear power plant (NPP) once again opened up the healed wound inflicted by radionuclides on the human body not only in Ukraine, but also in Belarus and the border regions of Russia. The drama of the situation was further intensified by the events surrounding the Zaporizhzhia NPP. This prompted us to turn to the archive of the Truskavetsian Scientific School of Balneology and process the results of research that, due to certain technical and ethical circumstances, remained unanalyzed. Material and methods. The cohort of observation in 1997 were 19 men and 3 women who were exposed to pathogenic factors of the accident at the Chоrnobylian nuclear power plant during the liquidation of its consequences in 1986. The subject of the study was EEG and HRV parameters. The survey was conducted twice - on admission and after two weeks of rehabilitation at the Truskavets’ Spa. Results. Screening of the registered parameters revealed a pronounced sympathotonic shift of the autonomic balance, as well as a statistically significant deviation from the norm of 18 EEG parameters (increase in 8 and decrease in 10). Under the influence of two-week balneotherapy, 5 increased and 5 decreased EEG parameters normalized, but the remaining abnormal EEG and HRV parameters were resistant to the influence of balneofactors. Conclusion. Neurophysiological disorders, detected even 11 years after the effects of the factors of the Chornobyl’ disaster, differ both in severity and sensitivity to the sanogenic effect of the adaptogenic factors of the Truskavets’ Spa.