bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activated Protein C Resistance Testing: An Update From Australasia/Asia‐Pacific
Authors: Favaloro Emmanuel J. , Arunachalam Sandya , Dean Elysse , Salwa Mahzuza , Ahuja Monica , Connelly Lynne , Chapman Kent , Vong Ronny , Pasalic Leonardo 
Published: February 2025

ABSTRACTIntroductionActivated protein C resistance (APCR) represents a risk factor for thrombosis and is usually due to factor V Leiden (FVL). Clinicians may order either test (i.e., APCR or FVL) to help assess ‘thrombophilia’ in patients who present with thrombosis. APCR testing is usually achieved using clot‐based assays, whereas FVL is assessed by genetic testing. There are advantages and disadvantages to either approach.MethodsWe report updated findings for APCR testing in our geographic region, in part using recent data from the RCPAQAP, an international external quality assessment (EQA) program, with some 50–60 participants for APCR testing over the past decade. Data have been updated to cover the past 13 years (2010–2023 inclusive), with four samples assessed each year, but with a primary focus on new data from 2020 to 2023 inclusive. In addition, data for APCR testing over several years from four large tertiary‐level hospital laboratories have been assessed following a recent change in instrumentation and haemostasis methods.ResultsEQA data continue to show variable performance in both numerical values and their interpretation for APCR testing, with certain methods providing more consistently correct findings than others. In addition, participant interpretation of their own numerical values and transcription errors seem problematic. Finally, the change in recent laboratory testing has also evidenced local improvements.ConclusionAPCR assays and testing laboratories continue to show variability in performance, with two methods (Pefakit and Staclot) showing the best performance overall. Targeted education may be of benefit, as most of the errors appear to originate from a small proportion of laboratories.
Simultaneous coinfection with influenza virus and an arbovirus impedes influenza‐specific but not Semliki Forest virus–specific responses
Authors: Foo Isabelle Jia‐Hui , Cabug Aira F , Gilbertson Brad , Fazakerley John K , Kedzierska Katherine , Kedzierski Lukasz 
Published: February 2025

AbstractOutbreaks of respiratory virus infections and arbovirus infections both pose a substantial threat to global public health. Clinically, both types of infection range from mild to severe and coinfections may occur more commonly than supposed. Our previous experimental coinfection study in mice demonstrated that prior infection with the arbovirus Semliki Forest virus (SFV) negatively impacted immune responses to influenza A virus (IAV). Here, we investigate whether simultaneous coinfection impacts the outcome of immune responses or disease. Simultaneous SFV and IAV infection did not lead to exacerbated or attenuated disease compared with the single virus infection control groups. SFV brain virus titers and brain pathology, including inflammation and immune responses, were comparable in the coinfection and single infection groups. By contrast, there was enhanced IAV replication, but no exacerbated lung pathology in coinfected mice. The magnitude of IAV‐specific CD8+ T‐cell responses in the lungs was lower compared with IAV‐only infection. Considered along with our previous study, this study provides evidence that the timing of viral coinfection is pivotal in determining effects on immune responses, pathological changes and disease outcome.
Beyond the WDR's state‐centrism: Multi‐level migration governance and migrant exclusion
Authors: Axster Sabrina , Beatty Riedl Rachel 
Published: February 2025

AbstractThe 2023 World Development Report, titled Migrants, Refugees, and Societies, analyses the state policies, laws, and labour market forces that determine the ability of migrants to improve their social and economic wellbeing. However, in its analysis the report adopts a state‐centric view, focusing predominantly on the state as the primary actor in the management of migration, thereby eliding a thorough analysis of how formal and informal institutions at the supranational and subnational levels impact the lives of migrants beyond citizenship. In this response, we instead argue for multi‐scalar analysis and evaluation of the policies that affect migrants. We illustrate how citizenship and access to its associated benefits are mediated at these multiple levels and bring compounding factors such as race, class, gender, religion, skill‐level, and rural or urban origin, among others, into view. This allows for a fuller analysis of the processes that shape migrant's experiences and lives.
‘It Gives Me Safety to Be Here’: Patients' Perspectives About Safety on Psychiatric Wards
Authors: Akinlotan Oladapo , O'Connor Allen , Peacham Beth , Crabb Lauren 
Published: February 2025

ABSTRACTProviding safe care within psychiatric wards is essential to promote the well‐being and recovery of patients on the wards. This can however be complicated because patients' behaviours can present risks to themselves and others. Understanding what patients think about safety on psychiatric wards holds crucial insight about addressing and managing safety issues on the wards. The aim of this study is to understand safety on psychiatric wards from the perspective of the patients. The study is a systematic review that follows PRISMA guidance and registered with PROSPERO. A comprehensive search of five electronic databases was completed. Searches were limited to peer‐reviewed academic journal articles published in English language from 2014 which examine safety on psychiatric settings from the patients' perspective. An initial result of 28 567 studies was filtered to six studies that met all the eligibility criteria. Quality assessment was completed using Critical Appraisal Skills Programme whereas data synthesis was conducted using thematic analysis. Four major themes that describe safety on psychiatric wards emerged: perception of safety; prevalence of lack of safety: perpetuating lack of safety; and promoting safety. Safety on psychiatric wards is like two sides of a coin: what promotes safety can also perpetuate lack of safety. The place (hospital), people (staff) and practice can both promote safety and perpetuate lack of safety. Finding and maintaining the right balance is crucial for achieving safety on psychiatric wards. These findings have implications for the effective management of safety issues on psychiatric wards.
Contemporary Factors Influencing Professional Identity in Acute Care Nurses: An Integrative Review
Authors: Howle Ashley , Carter Gregory , Reising Deanna 
Published: February 2025

ABSTRACTAimTo explore the current state of the science on influencing factors of acute care nursing professional identity.DesignIntegrative review.MethodsData were collected and screened using Covidence systematic review software, adhering to pre‐defined inclusion criteria. The Critical Appraisal Skills Programme checklist was used for critical appraisal, and content analysis was applied to analyse the data.Data SourcesCINAHL, PsycINFO and PubMed were utilised to search literature published between 2018 and 2023.ResultsA total of 18 articles were included. Five themes were identified: (1) internal influences; (2) external influences; (3) externalisation of role; (4) early versus seasoned career experiences and (5) barriers to professional identity formation.ConclusionThis review found evidence of multiple influencing factors, predominantly external, shaping acute care nurse professional identity. Research on the long‐term impacts on practice, management, policy and education remains limited.ImplicationsEnablers to forming professional identity foster empowerment, confidence, belonging and job satisfaction. Barriers to formation lead to hesitation, performance impediments, stress and exhaustion. Development of nurse professional identity may be instrumental in tackling acute care workforce challenges.ImpactReview findings on professional identity formation can guide initiatives for enhancing healthy work environments and workforce retention. This exploration has international contemporary relevance for the nursing profession with suggestions for future research.Impact StatementExisting literature underscores the significance of professional identity in nursing, yet the mechanisms underlying its integration and maintenance in the contemporary acute care workforce remain unclear. In the context of overwhelming workloads that adversely affect nurse mental health and retention, coupled with the escalating nursing shortage as we emerge from the pandemic, this examination of professional identity formation holds contemporary relevance for the evolving acute care landscape, offering implications for future research. The insights gleaned from this review may guide organisational leaders in developing new strategies addressing acute care nurse management, policy, education and retention.Reporting MethodReporting adheres to the EQUATOR network, ENTREQ guidelines.Patient or Public ContributionNone.
Comparison of Ultrasonography, CBCT, Transgingival Probing, Colour‐Coded and Periodontal Probe Transparency With Histological Gingival Thickness: A Diagnostic Accuracy Study Revisiting Thick Versus Thin Gingiva
Authors: Sabri Hamoun , Nava Paolo , Hazrati Parham , Alrmali Abdusalam , Galindo‐Fernandez Pablo , Saleh Muhammad H. A. , Calatrava Javier , Barootchi Shayan , Tavelli Lorenzo , Wang Hom‐Lay 
Published: February 2025

ABSTRACTAimTo assess the reliability of ultrasonographic, cone beam computed tomographic (CBCT), probe transparency and transgingival probing (TGP) methods in evaluating gingival thickness (GT), compared with the gold standard histological assessment.MethodsSixteen fresh cadaver heads with intact gingivae were used. The sequence for GT measurement included CBCT, ultrasonography, probe transparency, TGP and histology. Both stainless steel periodontal probe and colour‐coded probes were used for transparency. TGP involved a calibrated endodontic spreader, and histologic samples served as a comparative standard. Primary outcomes evaluated accuracy in GT measurement, while secondary outcomes assessed agreement among methods and established an optimal threshold for thin versus thick gingiva.ResultsOne hundred and fifteen teeth were examined, yielding a mean GT of 1.34 mm histologically. US and CBCT underestimated GT (means of 1.25 mm and 1.13 mm, respectively), while TGP overestimated (1.51 mm). Correlations (r = 0.88–0.98) and ICC values (0.73–0.95) indicated strong inter‐method agreement. Regression models significantly estimated histological GT from US, CBCT and TGP. A new 1.18 mm cut‐off, based on histology, improved diagnostic accuracy over the traditional 1 mm threshold.ConclusionsWhile histology remains the GT reference standard, US, CBCT and TGP achieved clinically acceptable accuracy. US showed the highest agreement with histology, followed by TGP and CBCT. The study supports US as the most practical non‐invasive tool, although CBCT and TGP remain viable options. Further clinical validation is recommended, acknowledging the limitations of cadaveric models in reflecting in vivo conditions.
A commentary on Kim et al.'s (2025) mapping the multifaceted approaches and impacts of adverse childhood experiences: an umbrella review of meta‐analyses for Journal of Child Psychology and Psychiatry's Annual Research Review
Authors: Herrenkohl Todd I. 
Published: February 2025

Research on Adverse Childhood Experiences (ACEs) has progresses at a rapid pace over the last 30 years and publications now span many fields and disciplines. With a literature this vast, it is important to stake stock of what is known and where gaps in knowledge remain by reviewing and synthesizing published findings. In this commentary, I center remarks on a well‐designed umbrella review conducted by Kim et al. on the impact of ACEs. Their review adds depth and precision to earlier reviews on this topic and draws attention to areas where further research is needed, including mechanisms underlying the transmission of risk and the onset of health‐related outcomes associated with ACE exposure. I conclude the commentary by echoing a call by Kim and colleagues for more investment in public health prevention to reduce ACE exposure, lessen trauma symptoms, and reduce costs to society.
Development of an Audit Tool to Evaluate End of Life Care in the Emergency Department: A Face and Content Validity Study
Authors: Heufel Melissa , Kourouche Sarah , Mitchell Rebecca , Cardona Magnolia , Thomas Benjamin , Lo Wing‐Shan Angela , Murgo Marghie , Vergan Debbie , Curtis Kate 
Published: February 2025

ABSTRACTObjectivesEmergency Departments (ED) are increasingly caring for patients with acute, chronic and terminal conditions requiring End of Life Care (EOLC). There is no published and validated tool available to evaluate EOLC delivery of patients dying in the ED. This study describes the face and content validity testing process to develop, refine and test a new and unique audit tool to evaluate EOLC in the ED.MethodsThe face and content validation process used a three‐round modified‐Delphi technique. We consulted 11 experts to assess the proposed 89 items. Face validity explored the overall question of appropriateness and relevance; and content validity examined relevance ratings using the Content Validity Index (CVI) 4‐point Likert scale in two rounds. Iterative assessment of ratings led to inclusion (CVI > 0.78), revision (CVI 0.65 to < 0.78) or exclusion (CVI < 0.65) of items from the tool.ResultsOf the initial 89 items, 66 were included (CVI > 0.78), 16 items revised (scores 0.65 to < 0.78), seven were removed (scores < 0.65) and two new items suggested. Items covered the constructs patient characteristics, circumstances of death, ED performance, communication and care planning, recognition of dying, care delivery, and needs of families and carers. Scale CVI achieved 0.90. The consolidated list of 81 items achieved acceptable face validity and excellent content validity.ConclusionFace and content validity of the ED EOLC audit tool achieved acceptable item‐CVI scores and an excellent scale‐CVI score. We recommend external validation of its components in real‐life settings to monitor and set locally relevant clinical practice benchmarks.
Determination of Minimum Alveolar Concentrations of Isoflurane and Effective Plasma Concentration of Propofol in Common Marmosets (Callithrix jacchus)
Authors: Muta Kanako , Koizumi Makoto , Miyabe‐Nishiwaki Takako , Sotomaru Yusuke , Nobukiyo Asako , Ohta Hiroki , Okano Hirotaka James , Kamata Masatoshi , Nagakubo Dai , Nishimura Ryohei 
Published: February 2025

ABSTRACTBackgroundCommon marmosets (Callithrix jacchus) have been widely used as laboratory animals; However, limited sedation and anesthetic protocols have yet to be established. In this study, the minimum alveolar concentration of an inhalant (isoflurane) and effective predicted plasma concentration of an injectable anesthetic (propofol) were measured for optimization of sedation and anesthetic protocols in marmosets.MethodsThe minimum alveolar concentrations (MACs) for several stimulations (nociceptive stimulation, endotracheal intubation, and non‐painful direct stimulation), MAC‐noci, MAC‐extb, and MAC‐awake, respectively, were measured for isoflurane with the up‐and‐down method from four healthy marmosets. Predicted plasma concentrations 50 (Cp50s), which are equivalent to MACs of isoflurane, Cp50‐noci, Cp50‐extb, and Cp50‐awake, respectively, were measured for propofol.ResultsMAC‐noci and MAC‐extb of isoflurane in marmosets were 1.91% and 1.38%, respectively. MAC‐awake was not determined owing to technical difficulties. Cp50‐noci, Cp50‐extb, and Cp50‐awake were 9.45, 7.21, and 3.54 μg/mL, respectively.ConclusionsThe obtained results refined existing isoflurane and propofol for sedation and anesthesia in marmosets.
From Nature to Nurture: The Science and Applications of Snail Slime in Health and Beauty
Authors: Rashad Muhammad , Sampò Simone , Cataldi Amelia , Zara Susi 
Published: February 2025

ABSTRACTBackgroundSnail slime (SS), a complex biological substance produced by various snail species, has garnered significant attention in recent years due to its diverse applications in health, cosmetics, and biotechnology.AimsOur previous review focused on the biological activities of SS, while the current one explores the science behind SS with a special focus on environmental factors affecting its quality and quantity, non‐lethal extraction methods, its composition, current applications in health and cosmetics followed by its emerging applications, and future prospects while achieving sustainability.MethodsA literature review on background, uses in health and cosmetics, and future prospects of SS was conducted. PubMed and Google Scholar were used to find the key articles exploring SS and the data is summarized and described here.ResultsExtraction methods range from traditional farming practices to advanced, non‐invasive techniques aimed at minimizing stress on snails. Emerging applications include potential use in sustained and targeted drug delivery systems, tissue engineering, and as components in advanced biomaterials. Future perspectives involve technological advancements in production, such as precision farming and biotechnology‐enhanced mucin production. The development of synthetic alternatives and sustainable practices is crucial for the industry's long‐term viability.ConclusionAs research continues to uncover new properties and applications, SS is poised to play an increasingly important role in the health and beauty industries, highlighting the need for balanced exploitation, standardization, quality control, and regulatory compliance in its production and use.
Critical Discourse Analysis in Reaction to Türkiye's Bill on the Euthanasia of Stray Animals: Revelations and Inferences
Authors: Utku‐Bilici Özlem , Bilici İlhan 
Published: February 2025

ABSTRACTThe phenomenon of animal rights has been a controversial issue i.e. not given proper priority but deserves utmost attention. The present study was designed in response to the increasing need to comprehend the unique being of animals within social boundaries. Besides, considering the ongoing discussions initiated in the varied recent studies as well as the contentious debates held within several up‐to‐date media sources, this study, designed as a single‐site case study, delved into the draft law that has been proposed by the Turkish government on euthanasia of stray animals. The data were obtained from six media platforms signifying three different editorial styles, namely pro‐government, anti‐government, and alternative channels. Three‐dimensional critical discourse analysis model and framing theory were simultaneously utilized to analyze the data. The findings revealed characteristic differences among six different media portals. The pro‐government channels were relatively cautious in reporting the bill whereas the anti‐government channels' agenda was generous in informing the public highly sensitively. Conversely, the alternative media platforms were found to be more neutral in demonstrating their responses to the draft law. Conclusively, case‐specific discoveries, perspectives, reflections, and insights were highlighted, and it was underscored that animals’ fundamental societal role requires more thorough acknowledgment and attention.
Who can work when, and why do we have to care? Education, care demands, and the gendered division of work schedules in France and Germany
Authors: Deuflhard Carolin , Ganault Jeanne 
Published: February 2025

AbstractObjectiveThis article investigates how education and the presence and age of children shape gendered work schedule arrangements among couples in France and Germany.BackgroundDespite the prevalence of nonstandard work schedules, schools and daycare facilities typically operate during standard work hours. Nevertheless, little is known on the gendered division of work schedules. Both France and Germany have shifted toward labor market deregulation, favoring the concentration of nonstandard schedules in lower‐class jobs. However, France provides full‐day public education and care. In Germany, public childcare is less comprehensive, and daycare and school hours are considerably shorter.MethodThe study uses sequence and cluster analysis on time‐use data (N = 11,268 days) to identify typical work schedules. Multinomial logistic regressions assess how education and the presence and age of children are associated with men's and women's types of days.ResultsIn both countries, less‐educated men were more likely to work shifts, whereas less‐educated women were more likely to not be employed. However, standard work schedules prevailed among better‐educated French men and women, whereas partial workdays and non‐workdays predominated among German women.ConclusionIn both labor market contexts, less‐educated partnered women rather than men seem to opt out of employment due to scheduling conflicts between work and care. However, more work‐facilitating family policies allow for more gender‐equal schedules among better‐educated men and women in France.
Causal Mechanisms in Corporate Social Responsibility (CSR) Management: A Meta‐Synthesis of Micro‐CSR Research
Authors: Remmer Stefanie , Gilbert Dirk Ulrich 
Published: February 2025

AbstractMuch psychologically oriented micro‐CSR research emphasizes intra‐individual processes, leading to a relative omission of the role of interactions among individuals in managing CSR. This limitation hinders the potential of such micro‐CSR research to explain CSR as an organizational‐level outcome. We adopt a meta‐synthesis methodology to extract insights on inter‐individual processes in CSR management from existing literature that examines CSR's microfoundations beyond a purely psychological perspective. By incorporating a causal mechanism approach into our meta‐synthesis, we develop a theoretical framework comprising three causal mechanisms that elucidate how individual behaviours and interactions of differing sets of dominant actor types (including change agents, supporters, opportunists, resisters and top and senior management) foster substantive or incremental progress in CSR or its obstruction within firms. Our findings establish a foundation for further research into individual‐level and temporal dynamics in CSR management, and the conditions under which firms are more likely to implement impactful CSR initiatives.