bluuebunny/crossref_metadata_2025_split huggingface dataset:
Masked nocturnal hypertension as a result of high prevalence of non-dippers among apparently well-controlled hypertensive patients with type 2 diabetes mellitus: data from a prospective study
Authors: Călin Pop , Viorel Manea , Luchiana Pruna , Mihaela Cosma , Lavinia Pop 
Published: September 2022

Abstract
Background
Ambulatory blood pressure monitoring (ABPM) in patients with diabetes mellitus (DM) and hypertension (HTN) show the dipping patterns, identify masked uncontrolled hypertension (MUCH), and demonstrate the effectiveness of the blood pressure (BP) treatment. MUCH is associated with a two-fold higher risk of adverse events. Prevalence in patients with DM is between 13.3 and 66.4%. Our study aims to investigate the prevalence of MUCH and the BP patterns in a population of apparently well-controlled hypertensive patients with type 2 DM (T2DM). A second aspect was the assessment of the effectiveness of antihypertensive treatment.

Methods
One hundred and sixty-three consecutively treated hypertensive patients with T2DM and an office BP between 130–139 and 80–89 mmHg performed a 24 h ABPM. The circadian BP variation, the presence of MUCH, and the correlations with the treatment were assessed.

Results
There were 75 dippers (46.02%), 77 non-dippers (47.23%), 4 reverse dippers (2.45%), and 7 extreme dippers (4.30%). Eighty-one patients (77 non-dippers + 4 reverse dippers; 49.7%) had isolated nocturnal MUCH according to the mean night ABPM criteria. Dippers and extreme dippers (75 dippers + 7 extreme dippers; 51.3%) did not have any MUCH criteria. The patients took, on an average, 3 antihypertensive drugs with no difference between those with controlled HTN and the isolated nocturnal MUCH group. Significant factors associated with isolated nocturnal MUCH and a non-dipping BP pattern included age > 65 years (OR = 1.9), DM duration > 10 years (OR = 1.4), HTN duration > 6.5 years (OR = 1.2), obesity (OR = 1.6), and cardiovascular comorbidities (OR = 1.4).

Conclusions
The current study shows that half of the treated hypertensive patients with T2DM and office clinical normotension are non-dippers or reverse dippers. They experience isolated nocturnal MUCH due to their elevated nocturnal BP values, which comply with the actual definition of masked nocturnal hypertension. Bedtime chronotherapy in those patients could be linked to better effectiveness of antihypertensive treatment during the night with the important goal of reducing cardiovascular and cerebrovascular adverse events. ABPM should be performed in hypertensive patients with DM for better risk stratification and more effective control of HTN.
Cushing syndrome as a failed cardiac screen in a patient with McCune–Albright syndrome: a case report
Authors: Foster Christy , Al Zubeidi Hiba , Diaz-Thomas Alicia 
Published: September 2022

Abstract
Background
McCune–Albright syndrome is a complex disorder encompassing multiple endocrinopathies. These manifestations are secondary to a mutation in the stimulatory G-protein alpha subunit. Cushing syndrome is due to autonomous secretory function of the adrenal gland and is present in 7.1% of patients with McCune–Albright syndrome. Cardiac newborn screenings assist in the identification of critical congenital heart disease. These screenings have become part of routine postnatal care nationwide.

Case report
A 6-week-old Caucasian male presented to a cardiologist at the University of Tennessee Health Science Center with left ventricular hypertrophy and poor feeding after a failed cardiac newborn screen. He had been previously seen at 2 weeks by a cardiologist on follow-up for abnormal critical congenital heart disease screening. Electrocardiogram and echocardiographic studies identified hypertrophic cardiomyopathy. Other examination findings revealed multiple characteristic café-au-lait lesions along with hypotonia and rounded facies. Given his cardiac disease, he was admitted to the hospital, where an evaluation was done for Cushing syndrome, showing elevated cortisol by immunoassay of 38 μg/dL (1.7–14.0 μg/dL, Vitros 5600) after a dexamethasone suppression test and urinary cortisol elevated to 35 μg/dL/24 hours (reference range 3–9 μg/dL/24 hours) (Esoterix; Calabasas, CA). He was started on metyrapone therapy to block synthesis of cortisol. His cortisol improved and was suppressed less than 2 μg/dL. His hypertension and clinical features of Cushing syndrome improved.

Conclusions
This case demonstrates a unique presentation of Cushing syndrome in a young infant. This is the first case to our knowledge showing significant left ventricular hypertrophy resulting from Cushing syndrome identified following a failure on a critical congenital heart disease screen. It highlights the importance of considering of McCune–Albright syndrome in patients with Cushing syndrome, especially if other clinical features are present. Medical therapy can be used to treat Cushing syndrome and can result in improvement in the cardiovascular pathology.
Machine learning for identification of silylated derivatives from mass spectra
Authors: Ljoncheva Milka , Stepišnik Tomaž , Kosjek Tina , Džeroski Sašo 
Published: September 2022

Abstract
Motivation
Compound structure identification is using increasingly more sophisticated computational tools, among which machine learning tools are a recent addition that quickly gains in importance. These tools, of which the method titled Compound Structure Identification:Input Output Kernel Regression (CSI:IOKR) is an excellent example, have been used to elucidate compound structure from mass spectral (MS) data with significant accuracy, confidence and speed. They have, however, largely focused on data coming from liquid chromatography coupled to tandem mass spectrometry (LC–MS).
Gas chromatography coupled to mass spectrometry (GC–MS) is an alternative which offers several advantages as compared to LC–MS, including higher data reproducibility. Of special importance is the substantial compound coverage offered by GC–MS, further expanded by derivatization procedures, such as silylation, which can improve the volatility, thermal stability and chromatographic peak shape of semi-volatile analytes. Despite these advantages and the increasing size of compound databases and MS libraries, GC–MS data have not yet been used by machine learning approaches to compound structure identification.

Results
This study presents a successful application of the CSI:IOKR machine learning method for the identification of environmental contaminants from GC–MS spectra. We use CSI:IOKR as an alternative to exhaustive search of MS libraries, independent of instrumental platform and data processing software. We use a comprehensive dataset of GC–MS spectra of trimethylsilyl derivatives and their molecular structures, derived from a large commercially available MS library, to train a model that maps between spectra and molecular structures. We test the learned model on a different dataset of GC–MS spectra of trimethylsilyl derivatives of environmental contaminants, generated in-house and made publicly available. The results show that 37% (resp. 50%) of the tested compounds are correctly ranked among the top 10 (resp. 20) candidate compounds suggested by the model. Even though spectral comparisons with reference standards or de novo structural elucidations are neccessary to validate the predictions, machine learning provides efficient candidate prioritization and reduction of the time spent for compound annotation.
Respiratory motion correction in F-18-FDG PET/CT impacts lymph node assessment in lung cancer patients
Authors: Noto Benjamin , Roll Wolfgang , Zinken Laura , Rischen Robert , Kerschke Laura , Evers Georg , Heindel Walter , Schäfers Michael , Büther Florian 
Published: September 2022

Abstract
Backgrounds
Elastic motion correction in PET has been shown to increase image quality and quantitative measurements of PET datasets affected by respiratory motion. However, little is known on the impact of respiratory motion correction on clinical image evaluation in oncologic PET. This study evaluated the impact of motion correction on expert readers’ lymph node assessment of lung cancer patients.

Methods
Forty-three patients undergoing F-18-FDG PET/CT for the staging of suspected lung cancer were included. Three different PET reconstructions were investigated: non-motion-corrected (“static”), belt gating-based motion-corrected (“BG-MC”) and data-driven gating-based motion-corrected (“DDG-MC”). Assessment was conducted independently by two nuclear medicine specialists blinded to the reconstruction method on a six-point scale $$s$$ ranging from “certainly negative” (1) to “certainly positive” (6). Differences in $$s$$ between reconstruction methods, accounting for variation caused by readers, were assessed by nonparametric regression analysis of longitudinal data. From $$s$$, a dichotomous score for N1, N2, and N3 (“negative,” “positive”) and a subjective certainty score were derived. SUV and metabolic tumor volumes (MTV) were compared between reconstruction methods.

Results
BG-MC resulted in higher scores for N1 compared to static (p = 0.001), whereas DDG-MC resulted in higher scores for N2 compared to static (p = 0.016). Motion correction resulted in the migration of N1 from tumor free to metastatic on the dichotomized score, consensually for both readers, in 3/43 cases and in 2 cases for N2. SUV was significantly higher for motion-corrected PET, while MTV was significantly lower (all p < 0.003). No significant differences in the certainty scores were noted.

Conclusions
PET motion correction resulted in significantly higher lymph node assessment scores of expert readers. Significant effects on quantitative PET parameters were seen; however, subjective reader certainty was not improved.
Analysis of prognostic factors of undifferentiated pleomorphic sarcoma and construction and validation of a prediction nomogram based on SEER database
Authors: Wang Zimao , Liu Jinhua , Han Jingjing , Yang Zheng , Wang Qiying 
Published: September 2022

AbstractBackgroundUndifferentiated pleomorphic sarcoma (UPS) is considered one of the most common types of soft tissue sarcoma (STS). Current studies have shown that the prognosis of UPS is related to some of its clinical characteristics, but no survival prediction model for the overall survival (OS) of UPS patients has been reported. The purpose of this study is to construct and validate a nomogram for predicting OS in UPS patients at 3, 5 years after the diagnosis.MethodsAccording to the inclusion and exclusion criteria, 1079 patients with UPS were screened from the SEER database and randomly divided into the training cohort (n = 755) and the validation cohort (n = 324). Patient demographic and clinicopathological characteristics were first described, and the correlation between the two groups was compared, using the Kaplan–Meier method and Cox regression analysis to determine independent prognostic factors. Based on the identified independent prognostic factors, a nomogram for OS in UPS patients was established using R language. The nomogram’s performance was then validated using multiple indicators, including the area under the receiver operating characteristic curve (AUC), consistency index (C-index), calibration curve, and decision curve analysis (DCA).ResultsBoth the C-index of the OS nomogram in the training cohort and the validation cohort were greater than 0 .75, and both the values of AUC were greater than 0.78. These four values were higher than their corresponding values in the TNM staging system, respectively. The calibration curves of the Nomogram prediction model and the TNM staging system were well fitted with the 45° line. Decision curve analysis showed that both the nomogram model and the TNM staging system had clinical net benefits over a wide range of threshold probabilities, and the nomogram had higher clinical net benefits than the TNM staging system as a whole.ConclusionWith good discrimination, accuracy, and clinical practicability, the nomogram can individualize the prediction of 3-year and 5-year OS in patients with UPS, which can provide a reference for clinicians and patients to make better clinical decisions.
Attitudes and stigma toward seeking psychological help among Saudi Adults
Authors: Alluhaibi Bushra A. , Awadalla Abdel W. 
Published: September 2022

AbstractBackgroundIn the Kingdom of Saudi Arabia (KSA), public attitudes and stigma toward mental health illness seem to prevent people from seeking psychological help, which negatively impacts an individual's life. The primary objective of this study was to investigate people's attitudes toward seeking psychological help and identify the extent to which the associated stigma is responsible for preventing them from seeking psychological help.MethodsTwo hundred eighteen adults recruited from the community living in the Eastern Province of the KSA completed the questionnaires, customized to create the Arabic version of Attitudes Toward Seeking Professional Psychological Help Scale-Short Form (ATSPPH-SF-A), the Arabic version of Stigma Scale for Receiving Psychological Help (SSRPH-A), and the Arabic version of Hopkins Symptom Checklist-25 (HSCL-25-A).ResultsBoth stigma and psychological distress significantly affected attitudes toward seeking professional help. Furthermore, it indicated that attitudes were negatively correlated with stigma while positively correlated with psychological distress. No significant difference in attitudes toward psychological help-seeking was identified between male and female participants. However, males displayed higher levels of stigma, while females showed greater psychological distress. Furthermore, the groups who received psychological treatment demonstrated more favorable attitudes toward seeking psychological help.ConclusionStigma and psychological stress influence attitudes toward treatment-seeking behavior for mental illness, making them two major predictors responsible for the underutilization of mental health services. More research is needed to assess specific sociodemographic disparities across more data sources and the factors that further contribute to stigma and psychological distress.
EFL learners’ grit, classroom enjoyment and their willingness to communicate: Iranian public school versus private English language institute learners
Authors: Ebn-Abbasi Faramarz , Nushi Musa 
Published: September 2022

AbstractThe pivotal role of communication in second language (L2) learning has triggered plethoric research to identify factors that may influence learners’ willingness to communicate (L2 WTC). However, there is a dearth of comparative research on L2 WTC, especially among EFL learners studying English at different educational institutions. To this end, the present study investigates the role of ‘grit’ and ‘classroom enjoyment’ (CE) in learners’ L2 WTC in two different educational settings of public schools and private language institutes. Grit includes two lower-order constructs, namely perseverance of effort (POE) and consistency of interest (COI), which were examined separately in this study. A total of 269 Iranian students from both public schools and private institutes completed an online survey. What was revealed from the data analysis through the Mann–Whitney u-test, Spearman’s rho, and multiple regression analysis is that private institute learners enjoyed higher levels of WTC compared to public school students. While POE and CE exerted a significant effect on L2 WTC in both educational settings, COI failed to do so. The findings of this study are discussed from a socio-educational perspective with regard to the difference between these two educational contexts.
Are home-based exercises effective to reduce blood pressure in hypertensive adults? A systematic review
Authors: Rodrigues Gabriel Dias , Lima Ligia Soares , da Silva Nicole Cristine Simões , Telles Paula Gomes Lopes , da Mota Silva Rocha Teresa Mell , de Aragão Porto Victor Quintella , Cardoso Viviane Veloso , da Silva Soares Pedro Paulo 
Published: September 2022

AbstractSedentarism and chronic non-communicable diseases have been a worldwide health problem that is drastically exacerbated by the COVID-19 pandemic social impacts. Home-based exercises are widely encouraged during social isolation to counterbalance the physical inactive impacts. Although, in the context of hypertension, are home-based exercises effective in blood pressure controlling? Our objective is to conduct a systematic review of high-quality controlled trials comparing the possible effects of different types of home-based exercises in hypertensive patients. The literature search was carried out in three scientific databases: Medline, Europe PMC, and Lilacs. Articles were included following three criteria: analyzing the effect of home-based exercise programs on blood pressure in treated and untreated hypertensive patients; exercises must perform at home and on the frequency, intensity, time, and type (FITT) principle, and the articles were published in English. From the qualitative analysis of 27 original trials screened through 451 identified studies, the main results are the following: 1) both endurance, isometric strength, and respiratory home-based exercise programs were efficient to decrease blood pressure in hypertensive patients; 2) differences in methodological approaches regarding FITT components, distinct blood pressure values at baseline and specific underlying mechanisms must be considered as a potential bias of each home-based interventions. In conclusion, endurance, isometric strength, and breathing home-based programs seems to be effective to reduce blood pressure in hypertensive patients. However, further randomized controlled trials and mechanistic studies must be performing to guide evidence-based recommendations of home-based exercises as antihypertensive therapy.
Acute retinal necrosis. Management and visual outcomes: a case series
Authors: Mojarrad Alireza , Omidtabrizi Arash , Ansari Astaneh Mohammadreza , Bakhtiari Elham , Shiezadeh Elham , Hassani Mohadeseh , Hosseini Seyedeh Maryam 
Published: September 2022

Abstract
Background
The present study reports the functional and anatomical outcomes of eyes with acute retinal necrosis(ARN).

Methods
This is a retrospective case series conducted at a tertiary Eye Hospital from March 2015 to March 2020. Medical records of patients with clinical and laboratorial—Polymerase Chain Reaction (PCR)—diagnosis of ARN were reviewed. To identify factors related to the outcomes of visual acuity(VA) and retinal detachment (RD) over time, Cox proportional hazards regression modeling and survival analyses were used.

Results
Twenty-three eyes of 23 patients (16 male, 7 female) were reviewed. Based on the PCR results, 16 cases (69.6%) had Varicella zoster virus, 3 cases (13%) had Cytomegalovirus, 1 patient (4.3%) had Herpes simplex virus associated ARN, and 1 case (4.3%) had negative PCR. The incident rate for ≥ 2-line VA gain was 0.28/eye-year (EY) (95% CI 0.21 ± 0.26) while the rate of severe vision loss was 0.09/eye-year (95% CI 0.05 ± 0.08). The RD development was observed at a rate of 0.43/eye-year (0.42 ± 0.02), which occurred in 9 eyes with a mean time of 100 days after the initial presentation of ARN. Patients’ age was the only factor associated with 2-line or more gain in VA over time with a hazard ratio of 0.921 (95% CI 0.854–0.993, P = 0.032).

Conclusions
Generally, although being crucial, treatment is not highly effective in improvement of VA and decrease of RD development, as well as vision loss, in patients with ARN. However, treatment prevents fellow eye involvement efficiently. Younger age is associated with better response to treatment and more chance to achieve better VA.
Optimization and kinetics studies of biodiesel synthesis from Jatropha curcas oil under the application of eco-friendly microwave heating technique: an environmentally benign and sustainable bio-waste management approach
Authors: Amesho Kassian T. T. , Lin Yuan-Chung , Chen Chin-En , Cheng Pei-Cheng , Ponnusamy Vinoth Kumar 
Published: September 2022

AbstractThis study attempts to synthesize biodiesel as a green liquid fuel from Jatropha curcas oil (JCO) utilizing waste eggshell (WES) as an effective and excellent sustainable source of the heterogeneous catalyst under the application of environmentally benign microwave heating technique. After preparing the CaO-based catalyst, diverse characterization techniques such as X-Ray Diffraction, Energy Dispersive Spectroscopy, Scanning Electron Microscopy, Fourier Transform Infrared, and Brunauer–Emmett–Teller were employed for characterization measurements. Under different optimized conditions, a considerable high biodiesel yield of 92% was attained while employing the following reaction conditions; methanol to oil molar ratio of 9:1, 5 wt% catalyst loading, 165 min reaction time with a microwave power of 800 W, and a 65 °C reaction temperature. The developed catalyst had significantly retained its reusability up to the 5th cycle of reuse. The catalysed transesterification process's activation energy of 38.5 kJ mol−1 demonstrated that the reaction is chemically controlled. Therefore, the WES has been utilized as a renewable base heterogeneous catalyst for novel biodiesel synthesis from JCO, which can be applied in diesel engines to lessen air pollution, specifically pollutant emissions from diesel vehicles. The results of this study are not for academic purposes only. They can also serve as models for industrial biodiesel production by exploiting bio-waste as catalysts and non-edible oils as feedstocks in microwave heating systems as environmentally friendly chemistry systems. In addition, our study uses non-consumable oil feedstock and bio-waste materials in an economical way to produce biofuel while contributing to environmental sustainability and sustainable bio-waste management. This approach extends to the existing state-of-the-art research.
Lysosomal storage diseases in the era of COVID-19: a report of an Egyptian case of alpha-fucosidosis and a summary of the lysosomal storage diseases-COVID-19 relationship
Authors: El-Amawy Heba Saed , Dawoud Heba 
Published: September 2022

AbstractBackgroundWe present a case of alpha-fucosidosis, a lysosomal storage disorder, from Egypt. The report also includes a brief review of the COVID-19 and lysosomal storage diseases relationship.Case presentationA female patient aged 18 years, diagnosed with type II fucosidosis, based on the cutaneous signs, characteristic facies, and systemic symptoms, and diagnosis was confirmed using genetic analysis. The patient died from COVID-19 pneumonia during the COVID-19 pandemic after getting the infection from her father and being hospitalized.ConclusionsPatients with lysosomal storage diseases with local or systemic immune suppression may be predisposed to respiratory complications of COVID-19. Intense care with protective guidelines should be applied to those patients.