bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily Oral Ibandronate With Adjuvant Endocrine Therapy in Postmenopausal Women With Estrogen Receptor–Positive Breast Cancer (BOOG 2006-04): Randomized Phase III TEAM-IIB Trial
Authors: Vliek Sonja B. , Noordhoek Iris , Meershoek-Klein Kranenbarg Elma , van Rossum Annelot G.J. , Dezentje Vincent O. , Jager Agnes , Hokken J.W. Esmeralda , Putter Hein , van der Velden Annette W.G. , Hendriks Mathijs P. , Bakker Sandra D. , van Riet Yvonne E.A. , Tjan-Heijnen Vivianne C.G. , Portielje Johanneke E.A. , Kroep Judith R. , Nortier Johan W.R. , van de Velde Cornelis J.H. , Linn Sabine C. 
Published: April 2022

PURPOSE For postmenopausal patients with breast cancer, previous subgroup analyses have shown a modest benefit from adjuvant bisphosphonate treatment. However, the efficacy of oral nitrogen-containing bisphosphonates such as ibandronate is unclear in this setting. TEAM-IIB investigates adjuvant ibandronate in postmenopausal women with estrogen receptor–positive (ER+) breast cancer. METHODS TEAM-IIB is a randomized, open-label, multicenter phase III study. Postmenopausal women with stage I-III ER+ breast cancer and an indication for adjuvant endocrine therapy (ET) were randomly assigned 1:1 to 5 years of ET with or without oral ibandronate 50 mg once daily for 3 years. Major ineligibility criteria were bilateral breast cancer, active gastroesophageal problems, and health conditions that might interfere with study treatment. Primary end point was disease-free survival (DFS), analyzed in the intention-to-treat population. RESULTS Between February 1, 2007, and May 27, 2014, 1,116 patients were enrolled, 565 to ET with ibandronate (ibandronate arm) and 551 to ET alone (control arm). Median follow-up was 8.5 years. DFS was not significantly different between the ibandronate and control arms (HR, 0.97; 95% CI, 0.76 to 1.24; log-rank P = .811). Three years after random assignment, DFS was 94% in the ibandronate arm and 91% in the control arm. Five years after random assignment, this was 89% and 86%, respectively. In the ibandronate arm, 97/565 (17%) of patients stopped ibandronate early because of adverse events. Significantly more patients experienced GI issues, mainly dyspepsia, in the ibandronate arm than in the control arm (89 [16%] and 54 [10%], respectively; P < .003). Eleven patients in the ibandronate arm developed osteonecrosis of the jaw. CONCLUSION In postmenopausal women with ER+ breast cancer, adjuvant ibandronate 50 mg once daily does not improve DFS and should not be recommended as part of standard treatment regimens.
Tislelizumab Versus Chemotherapy as Second-Line Treatment for Advanced or Metastatic Esophageal Squamous Cell Carcinoma (RATIONALE-302): A Randomized Phase III Study
Authors: Shen Lin , Kato Ken , Kim Sung-Bae , Ajani Jaffer A. , Zhao Kuaile , He Zhiyong , Yu Xinmin , Shu Yongqian , Luo Qi , Wang Jufeng , Chen Zhendong , Niu Zuoxing , Zhang Longzhen , Yi Tienan , Sun Jong-Mu , Chen Jianhua , Yu Guohua , Lin Chen-Yuan , Hara Hiroki , Bi Qing , Satoh Taroh , Pazo-Cid Roberto , Arkenau Hendrick-Tobias , Borg Christophe , Lordick Florian , Li Liyun , Ding Ningning , Tao Aiyang , Shi Jingwen , Van Cutsem Eric ,   for the RATIONALE-302 Investigators
Published: April 2022

PURPOSE Patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC) have poor prognosis. For these patients, treatment options are limited after first-line systemic therapy. PATIENTS AND METHODS In this open-label phase III clinical study, patients with advanced or metastatic ESCC, whose tumor progressed after first-line systemic treatment, were randomly assigned (1:1) to receive intravenous tislelizumab, an anti–programmed cell death protein 1 antibody, 200 mg every 3 weeks or chemotherapy (investigator's choice of paclitaxel, docetaxel, or irinotecan). The primary end point was overall survival (OS) in all patients. The key secondary end point was OS in patients with programmed death-ligand 1 tumor area positivity (TAP) score ≥ 10%. RESULTS In total, 512 patients across 11 countries/regions were randomly assigned. At final analysis, conducted after 410 death events occurred, OS was significantly longer with tislelizumab versus chemotherapy in all patients (median, 8.6 v 6.3 months; hazard ratio [HR], 0.70 [95% CI, 0.57 to 0.85]; one-sided P = .0001), and in patients with TAP ≥ 10% (median, 10.3 months v 6.8 months; HR, 0.54 [95% CI, 0.36 to 0.79]; one-sided P = .0006). Survival benefit was consistently observed across all predefined subgroups, including those defined by baseline TAP score, region, and race. Treatment with tislelizumab was associated with higher objective response rate (20.3% v 9.8%) and a more durable antitumor response (median, 7.1 months v 4.0 months) versus chemotherapy in all patients. Fewer patients experienced ≥ grade 3 treatment-related adverse events (18.8% v 55.8%) with tislelizumab versus chemotherapy. CONCLUSION Tislelizumab significantly improved OS compared with chemotherapy as second-line therapy in patients with advanced or metastatic ESCC, with a tolerable safety profile. Patients with programmed death-ligand 1 TAP ≥ 10% also demonstrated statistically significant survival benefit with tislelizumab versus chemotherapy.
Chromosome 3p25.3 Gain Is Associated With Cisplatin Resistance and Is an Independent Predictor of Poor Outcome in Male Malignant Germ Cell Tumors
Authors: Timmerman Dennis M. , Eleveld Thomas F. , Sriram Sruthi , Dorssers Lambert C.J. , Gillis Ad J.M. , Schmidtova Silvia , Kalavska Katarina , van de Werken Harmen J.G. , Oing Christoph , Honecker Friedemann , Mego Michal , Looijenga Leendert H.J. 
Published: April 2022

PURPOSE Cisplatin is the main systemic treatment modality for male type II germ cell tumors (GCTs). Although generally very effective, 5%-10% of patients suffer from cisplatin-resistant disease. Identification of the driving mechanisms of resistance will enable improved risk stratification and development of alternative treatments. METHODS We developed and characterized cisplatin-resistant GCT cell line models and compared their molecular characteristics with patient samples with cisplatin resistance and/or a poor clinical outcome. Subsequently, the association between the overlapping genetic features and clinical data was assessed. Finally, we used Cox regression to determine the prognostic relevance of these features within the currently used risk classification. RESULTS Gain of chromosome 3p25.3 was detected in all cisplatin-resistant cell lines, and copy number of this region correlated with the level of resistance (R = 0.96, P = 1.5e-04). Gain of this region was detected at low frequencies in primary tumors and at higher frequencies in relapsed and/or cisplatin-resistant tumors. Chromosome 3p25.3 gain was associated with shorter progression-free survival and overall survival, with the strongest association observed in nonseminomas excluding pure teratomas. 3p25.3 gain was more frequently observed in tumors with yolk sac tumor histology and predicted adverse outcome independent of the International Germ Cell Cancer Collaborative Group risk classification and the presence of TP53/ MDM2 alterations. CONCLUSION On the basis of both in vitro analyses and clinical data, we found 3p25.3 to be strongly associated with cisplatin resistance and poor clinical outcome in male type II GCTs. Using genomic profiling, 3p25.3 status could help to improve risk stratification in male patients with type II GCT. Further characterization of this locus and underlying mechanisms of resistance is warranted to guide development of novel treatment approaches for cisplatin-resistant disease.
Religiosity and Young Unmarried Women's Sexual and Contraceptive Behavior: New Evidence From a Longitudinal Panel of Young Adult Women
Authors: Brooks Isabel H. McLoughlin , Weitzman Abigail 
Published: April 2022

Abstract
Drawing on weekly panel data from the Relationship Dynamics and Social Life study, we investigate the relationship between religiosity and young Christian women's premarital intercourse, hormonal contraceptive use, and condom use for a period of up to 2.5 years. Mediation analyses reveal what explains the relationship between baseline religiosity and young women's subsequent reproductive behaviors, with consideration for their normative environments, moral order and learned competencies, attitudes, and anticipated guilt after sex. Results indicate that the more religious a young woman is, the less likely she is to have intercourse and to use hormonal contraception in a given week. However, when having intercourse and not using a hormonal method, the more religious a young woman is, the more likely she is to use condoms. Religiosity's relationship to these behaviors operates largely through women's reproductive attitudes, anticipated feelings of guilt after sex, and past sexual or contraceptive behaviors. Together, these findings highlight the complex relationship between religiosity and premarital sex and contraceptive use, elucidate key pathways through which religiosity operates, and draw attention to the often overlooked role of sexual emotions.
Fulfillment of Patient Expectations After Spine Surgery is Critical to Patient Satisfaction: A Cohort Study of Spine Surgery Patients
Authors: Rampersaud Y. Raja , Canizares Mayilee , Perruccio Anthony V. , Abraham Edward , Bailey Christopher S. , Christie Sean D. , Evaniew Nathan , Finkelstein Joel A. , Glennie Raymond Andrew , Johnson Michael G. , Nataraj Andrew , Paquet Jerome , Phan Philippe , Weber Michael H. , Thomas Kenneth , Manson Neil , Hall Hamilton , Fisher Charles G. 
Published: April 2022

BACKGROUND:
Patient satisfaction is an important indicator used to monitor quality of care and outcomes after spine surgery.

OBJECTIVE:
To examine the complex relationship between preoperative expectations, fulfillment of expectations, postsurgical outcomes, and satisfaction after spine surgery.

METHODS:
In this national study of patients undergoing elective surgery for degenerative spinal conditions from the Canadian Spine Outcomes and Research Network Registry, we used logistic regression to examine the relationships between patient satisfaction with surgery (1-5 scale), preoperative expectation score (0 = none to 100 = highest), fulfillment of expectations, and disability and pain improvement.

RESULTS:
Fifty-eight percent of patients were extremely satisfied, and 3% were extremely dissatisfied. Expectations were variable and generally high (mean 79.5 of 100) while 17.3% reported that none of their expectations were met, 49.8% reported that their most important expectation was met, and 32.9% reported that their most important expectation was not met but others were. The results from the fully adjusted ordinal logistic model for satisfaction indicate that satisfaction was higher among patients with higher preoperative expectations (odds ratio [OR] [95% CI]: 1.11, [1.04-1.19]), reporting important improvements in disability (OR [95% CI]: 2.52 [1.96-3.25]) and pain (OR [95% CI]: 1.64 [1.25-2.15]) and reporting that expectations were fulfilled (OR = 80.15, for all expectations were met). The results were similar for lumbar and cervical patients.

CONCLUSION:
Given the dominant impact of expectation fulfillment on satisfaction level, there is an opportunity for improving overall patient satisfaction by specifically assessing and mitigating the potential discrepancies between patients' preoperative expectations and likely surgical outcomes. The findings are likely relevant across elective surgical populations.
Efficacy of Exercise for Fall Prevention in Older Adults
Authors: Bechtel Meredith , Garber Carol Ewing 
Published: April 2022

Apply It!
• The exercise professional will be given evidenced-based effective exercises to be used for fall mitigation and prevention purposes with older adults.
• The exercise professional will learn to look for common risk factors for falling in an assessment and how to address these in an exercise program.
• The exercise professional will be provided with strategies for successful work with a client who experiences fear of falling.
Effective Contract As a Means of Monitoring of the Professional Achievements of a Scientific and Pedagogical Worker
Authors: MINCHENKO Vladimir , Poddubnaya Tatiana , ZADNEPROVSKAYA Elena , Khatit Fatima 
Published: April 2022

Based on the analysis and generalization of research, the experience of implementing effective contracts in the activities of universities, the article provides a rationale for an effective contract as a means of monitoring the professional achievements of a scientific and pedagogical worker in the context of a comprehensive assessment of the effectiveness of the university. The purpose of the article is to reveal the historical roots of the implementation of an effective contract in the practice of higher educational institutions, to describe its functional purpose, main characteristics and implementation experience. The authors reveal the reasons for the transition of universities to a criterion assessment of the effectiveness of the professional activities of scientific and pedagogical workers, the concept and principles of the development and implementation of an effective contract are given, variations in the criteria and indicators of teachers' performance reflected in an effective contract, as well as mechanisms for their provision and accounting are presented. The study allows you to develop an understanding of an effective contract as a method of objective complex assessment of the results of scientific and pedagogical work and an innovative mechanism of educational management.
The research materials deepen the understanding of monitoring the professional activity of a scientific and pedagogical worker in the context of globalization, which complements the existing scientific understanding of the determinants of systemic changes in the professional activity of a higher school teacher and theoretical ideas in the field of educational qualimetry.
Immediate neurotropic effects of ukrainian phytocomposition
Authors: Ruzhylo Sofiya , Fihura Oksana , Zukow Walery , Popovych Igor 
Published: April 2022

Background. Previous experimental and clinical-physiological studies have shown that the Ukrainian phytocomposition “Balm Kryms’kyi” has adaptogenic properties, which are manifested in its vegetative, endocrine, immunotropic, coagulotropic, actotropic and metabolic effects. However, the neurotropic properties of the phytocomposition remain unclear, which is the purpose of this study. Materials and methods. The object of observation were 12 women (44±13 years) and 62 men (44±12 years) with dysfunction of neuro-endocrine-immune complex. HRV and EEG parameters were recorded in the morning in basal conditions. Then the members of the main group used 5 ml of phytocomposition dissolved in 45 ml of tap water, instead in the control group used 50 ml of the latter. After 1,5 hours, the test was repeated. Results. Discriminant analysis revealed 30 EEG parameters and 4 HRV parameters characteristic of the initial state and after consumption of phytocomposition or tap water. Conclusion. Ukrainian phytocomposition “Balm Truskavets” causes immediate neurotropic effects at patients with dysfunction of neuro-endocrine-immune complex.
An Operations Research–Based Teaching Unit for Grade 10: The ROAR Experience, Part I
Authors: Colajanni Gabriella , Gobbi Alessandro , Picchi Marinella , Raffaele Alice , Taranto Eugenia 
Published: April 2022

We introduce Ricerca Operativa Applicazioni Reali (ROAR; in English, Real Applications of Operations Research), a three-year project for higher secondary schools. Its main aim is to improve students’ interest, motivation, and skills related to Science, Technology, Engineering, and Mathematics disciplines by integrating mathematics and computer science through operations research. ROAR offers examples and problems closely connected with students’ everyday life or with the industrial reality, balancing mathematical modeling and algorithmics. The project is composed of three teaching units, addressed to grades 10, 11, and 12. The implementation of the first teaching unit took place in Spring 2021 at the scientific high school IIS Antonietti in Iseo (Brescia, Italy). In particular, in this paper, we provide a full description of this first teaching unit in terms of objectives, prerequisites, topics and methods, organization of the lectures, and digital technologies used. Moreover, we analyze the feedback received from students and teachers involved in the experimentation, and we discuss advantages and disadvantages related to distance learning that we had to adopt because of the COVID-19 pandemic. Funding: E. Taranto and G. Colajanni were partially supported by the research projects “Programma Ricerca di Ateneo UNICT 2020-22 linea 2,” “EEEP&DLaD,” and “OMNIA” of the University of Catania. Supplemental Material: The online appendix is available at https://doi.org/10.1287/ited.2022.0271 .
PEMBENTUKAN KARAKTER KREATIF MELALUI EKSTRAKURIKULER HIZBUL WATHAN DI SD MUHAMMADIYAH KARANGKAJEN II YOGYAKARTA
Authors: Wulandari Monika Feby , Hidayah Nur 
Published: April 2022

Penelitian ini bertujuan untuk mendeskripsikan pembentukan karakter kreatif melalui ekstrakurikuler Hizbul Wathan di SD Muhammadiyah Karangkajen II Yogyakarta. Jenis penelitian yang digunakan adalah penelitian kualitatif dalam bentuk deskriptif. Subjek penelitian ini adalah pembina, kepala sekolah, dan peserta didik kelas IV dan V. Objek penelitian ini adalah pembentukan karakter kreatif peserta didik melalui ekstrakurikuler Hizbul Wathan. Teknik pengumpulan data melalui wawancara dan dokumentasi. Keabsahan data menggunakan teknik triangulasi sumber dan metode. Teknik analisis data berdasarkan teori Miles dan Huberman yaitu data reduction, data display, dan conclusion drawing/verification. Hasil penelitian menunjukkan bahwa pembentukan karakter kreatif peserta didik melalui ekstrakurikuler Hizbul Wathan di SD Muhammadiyah Karangkajen II Yogyakarta dilakukan berdasarkan metode kepanduan Hizbul Wathan yaitu: (1) Pemberdayaan anak didik lewat sistem beregu; (2) Kegiatan yang dilakukan di alam terbuka; (3) Pendidikan dengan metode yang menarik, menyenangkan, dan menantang; (4) Penggunaan sistem kenaikan tingkat dan tanda kecakapan; (5) Sistem satuan dan kegiatan terpisah antara pandu putera dan pandu puteri. Karakter kreatif peserta didik yang terbentuk melalui ekstrakurikuler Hizbul Wathan di SD Muhmmadiyah Karangkajen II yaitu hasrat keingintahuan yang cukup besar, bersikap terbuka terhadap pengalaman baru, panjang akal, keingintahuan untuk menemukan, cenderung lebih menyukaiÂ tugas yang berat dan sulit, cenderung mencari jawaban yang luas dan memuaskan, memiliki dedikasi bergairah serta aktif dalam melaksanakan tugas, berfikir fleksibel, kemampuan membuat analisis dan sintesis, memiliki semangat bertanya serta meneliti, dan memiliki daya abstraksi yang cukup baik.
STRATEGI PENILAIAN PEMBELAJARAN MATEMATIKA PADA MASA PANDEMI COVID-19 DI KELAS TINGGI SEKOLAH DASAR
Authors: Yantoro Yantoro , Hayati Suci , Rahmad Rahmad 
Published: April 2022

Penelitian ini bertujuan untuk mendeskripsikan strategi guru dalam melaksanakan penilaian pembelajaran matematika pada masa pandemi Covid-19 di kelas tinggi sekolah dasar. Penelitian ini dilakukan di SD Negeri 34/I Teratai pada bulan Januari sampai dengan Februari 2021. Pengumpulan data dalam penelitian ini dilakukan dengan cara observasi, wawancara, dan dokumentasi. Setelah data dikumpulkan, data dianalisis secara kualitatif. Hasil penelitian ini menunjukkan bahwa penilaian pembelajaran matematika pada masa pandemi Covid-19 ini hanya berfokus kepada penilaian kognitif peserta didik, maka dari itu guru memiliki strategi dalam melaksanakan penilaian pembelajaran matematika supaya bisa memberikan gambaran nyata dari kemampuan peserta didik. Strategi yang guru gunakan dalam penilaian pembelajaran matematika yaitu (1) Melakukan penilaian pembelajaran secara tatap muka langsung. (2) Penilaian berdasarkan tugas harian peserta didik. (3) Penilaian berdasarkan kehadiran peserta didik. (4) Merujuk pada nilai rapor semester sebelumnya. Pembelajaran matematika pada masa pandemi Covid-19 ini membuat guru menjadi berjarak dengan peserta didiknya, sehingga guru perlu memiliki strategi penilaian pembelajaran matematika yang dapat membantu guruÂ Â memberikan penilaian secara utuh yang merupakan gambaran kemampuan peserta didik yang sebenarnya.Dari hasil penelitian ini dapat disimpulkan bahwa strategi guru dalam melaksanakan penilaian pembelajaran matematika pada masa pandemi saat ini berlangsung efektif dalam mengetahui kemampuan peserta didik yang sebenarnya, mengingat bahwa tugas-tugas yang diberikan guru melalui pembelajaran jarak jauh tidak serta merta dikerjakan oleh peserta didik itu sendiri, namun juga dapat dikerjakan oleh orang lain.
The relationship between patient-reported outcomes and preoperative pain characteristics in patients who underwent total hip arthroplasty
Authors: Everett Brandon Paul , Sherrill Garrett , Nakonezny Paul A. , Wells Joel E. 
Published: April 2022

Aims This study aims to answer the following questions in patients with hip osteoarthritis (OA) who underwent total hip arthroplasty (THA): are patient-reported outcome measures (PROMs) affected by the location of the maximum severity of pain?; are PROMs affected by the presence of non-groin pain?; are PROMs affected by the severity of pain?; and are PROMs affected by the number of pain locations? Methods We reviewed 336 hips (305 patients) treated with THA for hip OA from December 2016 to November 2019 using pain location/severity questionnaires, modified Harris Hip Score (mHHS), Hip Outcome Score (HOS), international Hip Outcome Tool (iHOT-12) score, and radiological analysis. Descriptive statistics, analysis of covariance (ANCOVA), and Spearman partial correlation coefficients were used. Results There was a significant difference in iHOT-12 scores between groups experiencing the most severe pain in the groin and the trochanter (p = 0.039). Additionally, more favourable mHHS scores were related to the presence of preoperative pain in trochanter (p = 0.049), lower back (p = 0.056), lateral thigh (p = 0.034), and posterior thigh (p = 0.005). Finally, the maximum severity of preoperative pain and number of pain locations had no significant relationship with PROMs (maximum severity: HHS: p = 0.928, HOS: p = 0.163, iHOT-12 p = 0.233; number of pain locations: HHS: p = 0.211; HOS: p = 0.801; iHOT-12: p = 0.112). Conclusion Although there was a significant difference in iHOT-12 scores between patients with the most severe pain in the groin or trochanter, and the presence of pain in the trochanter, lower back, lateral thigh, or posterior thigh was related to higher mHHS scores, the majority of preoperative pain characteristics did not have a significant impact on outcomes. Therefore, a broad array of patients with hip OA might expect similar, favourable outcomes from THA notwithstanding preoperative pain characteristics. Cite this article: Bone Jt Open 2022;3(4):332–339.