bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival trends of patients with non‐metastatic gastric adenocarcinoma in the US and European countries: the impact of decreasing resection rates
Authors: Huang Lei , Jansen Lina , Verhoeven Rob H.A. , Ruurda Jelle P. , Van Eycken Liesbet , De Schutter Harlinde , Johansson Jan , Lindblad Mats , Johannesen Tom B. , Zadnik Vesna , Žagar Tina , Lagarde Sjoerd M. , van de Velde Cornelis J.H. , Schrotz‐King Petra , Brenner Hermann 
Published: June 2022

AbstractBackgroundWe previously observed decreasing resection rates of non‐metastatic gastric adenocarcinoma (GaC) in the US and some European countries. If and to what extent these trends affect the trends in overall survival (OS) of patients with non‐metastatic GaC at the population level remain unclear. This large international population‐based cohort study aimed to assess the impact of the previously observed decreasing resection rates on multivariable‐adjusted trends in the long‐term OS of patients with non‐metastatic GaC.MethodsIndividual‐level data of patients with non‐metastatic GaC were obtained from the national cancer registries of the Netherlands, Belgium, Sweden, Norway, and Slovenia, and the US Surveillance, Epidemiology, and End Results database. We analyzed data for each country separately. Associations between year of diagnosis and OS were assessed using Cox proportional hazards regression model with adjustment for multiple prognostic variables, with and without including resection and chemotherapy as potential explanatory variables.ResultsA total of 66,398 non‐metastatic GaC patients diagnosed in 2003‐2016 were analyzed, with an accumulated follow‐up of 172,357 person‐years. Without adjustment for resection, OS was improved only slightly in the US [hazard ratio (HR)per year = 0.99; HR≥ vs. <2010 = 0.96], and no improvement was observed in the investigated European countries, with OS even worsening in Sweden (HRper year = 1.03; HR≥ vs. <2010 = 1.17). After adjusting for resection, the increasing OS trend became stronger in the US (HRper year = 0.98; HR≥ vs. <2010 = 0.88), and the temporal trend became insignificant in Sweden. In Slovenia (HRper year = 0.99; HR≥ vs. <2010 = 0.92) and Norway (HRper year = 0.97; HR≥ vs. <2010 = 0.86), improved OS over time emerged after resection adjustment. Improved OS in patients undergoing resection was observed in the US, the Netherlands, and Norway. Adjustment for chemotherapy did not alter the observed associations. Stratified analyses by tumor location showed mostly similar results with the findings in all patients with non‐metastatic GaCs regarding the associations between year of diagnosis and survival.ConclusionsOS of patients with non‐metastatic GaC mostly did not improve in selected European countries and was even worsened in Sweden, while it was slightly increased in the US in the early 21st century. Progress in OS of patients with non‐metastatic GaC seems to have been impeded to a large extent by decreasing rates of resection.
Oxaspiro Indiculides from Old Woman Octopus Cistopus indicus as Dual Inhibitors of Inducible Cyclooxygenase and Lipoxygenase
Authors: Kunnappilly Paulose Silpa , Chakraborty Kajal 
Published: June 2022

AbstractThe organic extract of the old woman octopus Cistopus indicus (Octopodidae), ubiquitous in the Central and South Indo‐Pacific to the tropical Indian Ocean, was chromatographically fractionated over a reverse‐phase adsorbent to yield two oxygenated spiro heterocyclic compounds, named indiculides A and B. Their structures were elucidated by using comprehensive spectroscopic methods. The radical scavenging potential displayed by indiculide A (IC50 ∼1.2 mM) besides attenuating the cyclooxygenase isoforms (COX‐1/COX‐2; IC50 3.36/3.02 μM) showed considerably superior activities when equated to those showed by indiculide B (IC50 3.45/3.22 μM). The inhibition property of indiculide A against 5‐LOX (IC50 2.57 μM) was significantly greater than that of the standard 5‐LOX inhibitor zileuton (IC50 3.70 μM, p<0.05). A greater selectivity index (anti‐COX‐1/anti‐COX‐2, 1.11) was perceived for indiculide A than that demonstrated by indiculide B (1.07) and anti‐inflammatory drug diclofenac (0.96). Structure bio‐activity relation study of indiculide A disclosed proportionality to the electronic properties besides permissible hydrophobicity‐lipophilicity equilibrium, which could result in its efficient interface with the active site of inflammatory enzyme causing promising anti‐inflammatory potential. Larger hydrogen bond networks of indiculide A on account of the more electronic‐rich centers in conjunction with reduced docking factors reinforced its noteworthy attenuation potential against 5‐LOX. The in vitro bioactivity assessment and in silico docking results were further validated by the superior drug‐like characteristics of indiculide A (drug‐likeness score, 0.21) than B analog, and therefore, the former metabolite could be a potential anti‐inflammatory lead.
Comparative evaluation of the nutritional value of faba bean flours and protein isolates with major legumes in the market
Authors: Shi Dai , House James D. , Wanasundara Janitha P. D. , Nickerson Michael T. 
Published: June 2022

AbstractBackground and ObjectivesThe plant protein market has been growing at an unprecedented rate. To evaluate the utilization potential of Canadian faba beans, the nutritional value of flours and protein isolates of cultivars Fabelle, Malik, and Snowbird were compared to yellow pea (CDC Amarillo) and soy (AAC 26‐15), the two major players in the legume protein market.FindingsFaba bean was largely comparable to pea and soy for total phenolic compounds, condensed tannins, and phytic acid (PA) contents, less concentrated with the raffinose family oligosaccharides, and contained additional vicine and convicine (V‐C) at varying levels. However, it was more limiting in methionine and cysteine and had lower protein quality, particularly in the isolates (in vitro protein digestibility corrected amino acid score, or IV‐PDCAAS < 50%). Among cultivars, Fabelle was the lowest and highest in V‐C and PA, respectively, and Snowbird showed the lowest protein quality.ConclusionsFaba bean flours showed higher protein quality values than the isolates, possibly due to the loss of albumins during the extraction process. Future research should focus on the modification of wet fractionation methods to minimize the loss of sulfur‐rich amino acids.Significance and NoveltyThe findings show a clear picture of how recent faba bean cultivars grown in Canada compared nutritionally to each other and pea and soy, providing insights on ingredient selection and processing.
Mesoporous Silica Supported Highly Dispersed GaN Catalysts Synthesized by Thermal Atomic Layer Deposition for Propane Dehydrogenation
Authors: Zhang Wangle , Li Jianguo , Hui Longfei , Gong Ting , Qin Lijun , Lu Jian , Feng Hao 
Published: June 2022

AbstractAs a typical wide band gap semiconductor material, gallium nitride (GaN) has found extensive applications in electronic related fields. This material could also make a promising catalyst. However, due to the difficulty of synthesizing high surface area GaN, its applications in catalysis have been greatly constrained. In this work, we report a novel method of synthesizing high surface area GaN catalysts supported on mesoporous silica (MCM‐41) using thermal atomic layer deposition (ALD). Trimethyl gallium and ammonia were alternately dosed in the temperature range between 400–500 °C to generate nanoparticles of GaN on the support. Formation of highly dispersed GaN nanoparticles was confirmed and their structural and physiochemical properties were investigated. Structural characterization results reveal that amorphous GaN could be deposited on MCM‐41 at 400 °C while crystalline GaN could only be formed at temperatures≥500 °C and with multiple cycles of ALD. In propane dehydrogenation (PDH) reaction the ALD GaN/MCM‐41 catalysts demonstrated excellent activity and selectivity. The specific activity of amorphous GaN turned out to be better than crystalline GaN, probably due to the larger fraction of active species exposed on the surface. Density function theory calculation was used to analyze the catalytic process and mechanism of PDH on supported GaN. It was revealed that GaN was active in the cleavage of C−H bond in propane. Amorphous GaN facilitates the adsorption of propane, which could also contribute to the enhanced activity of amorphous GaN.
Enhanced Effect of the Mesoporous Carbon on Iron Carbide Catalyst for Hydrogenation of Dimethyl Oxalate to Ethanol
Authors: Cao Meng , Huang Huijiang , Zheng Yuntao , Zhang Qiaochu , Wang Shengping , Ge Rile , Wang Junhu , Zhao Yujun , Ma Xinbin 
Published: June 2022

AbstractDue to the low activity of bulk Fe5C2 catalyst in the hydrogenation of dimethyl oxalate to ethanol, a supported Fe5C2 catalyst was designed and prepared with mesoporous carbon as the carrier. For a comparison, two iron carbide catalysts supported on activated carbon and microporous carbon were also prepared. Based on the characterization results of IR, XRD, H2‐TPR, CO‐TPD, XPS and MES, the oxygen‐containing functional groups (especially COOH group) on the surface of the carbon supports inhibit the formation of iron carbides, which are regarded as the active sites and play the key role in the hydrogenation of dimethyl oxalate to ethanol. However, the mesoporous carbon exhibits a more positive effect on the dispersion of iron particles than the other two carbon supports. As a result, the as‐prepared mesoporous catalyst presents an excellent activity (the ethanol yield of 85.8 %) and stability in the hydrogenation of dimethyl oxalate. This work suggests a practical strategy in fabricating a supported iron carbides catalyst for the chemosynthesis of ethanol via DMO hydrogenation from syngas.
Cognitive deficiency, parental relationship, and coping strategies are related with anxiety and depression among parents of children with epilepsy
Authors: Ren Zhengjia , Yang Chunsong , Yu Dan 
Published: June 2022

AbstractBackgroundThe diagnosis of epilepsy in a child often and understandably causes psychological adjustment difficulties in the parents. To help parents of children with epilepsy cope with stress, it is important to understand how parents cope with the sickness of their child. The objective of this study was to assess factors related to the state of anxiety and depression among parents of children with epilepsy.MethodsThe present study was a cross‐sectional study, and the data were collected through an anonymous, Internet‐based survey platform between October 2018 and October 2019 from 250 participants aged 22–65 years. Participants were invited to fill questionnaires include socioeconomic questionnaire, anxiety, depression, and coping strategies scale.ResultAmong the parents of children with epilepsy, 48.8% (122/250) had depressive symptoms (Patient Health Questionnaire‐9 [PHQ‐9] score >4) and 46.4% (116/250) had anxiety symptoms (7‐item Generalized Anxiety Disorder [GAD‐7] score >5). Depression among parents of children with epilepsy was significantly associated with comorbidity (odds ratio [OR] = 0.392, 95% CI = 0.182–0.846), a poor parental relationship (OR = 0.283, 95% CI = 0.130–0.614), positive coping (OR = 0.947, 95% CI = 0.903–0.992), and negative coping (OR = 1.287, 95% CI = 1.179–1.405). Anxiety among parents of children with epilepsy was significantly associated with a poor parental relationship (OR = 0.416, 95% CI = 0.207–0.835) and negative coping (OR = 1.155, 95% CI = 1.087–1.228).ConclusionsThe present study indicates the importance of couple support and providing effective coping to make parents of children with epilepsy more resilient in the presence of negative life events, especially for parents of children with comorbidity with cognitive deficiency.
Acute necrotic disorder of the small intestine post‐coronavirus disease‐2019 vaccination
Authors: Nishimura Tomoyuki , Onogawa Seiji , Yamamoto Takuya , Okuda Yasuhiro , Ikeda Morito , Matsumoto Nozomu , Kurihara Keisuke , Shimizu Akinori , Kitamura Shosuke , Katamura Yoshio , Hirano Naomichi , Itamoto Shingo , Nakahara Masahiro , Yonehara Shuji , Shimamoto Fumio , Hanada Keiji 
Published: June 2022

AbstractThe Pfizer‐BioNTech coronavirus disease 2019 (COVID‐19) vaccine is extensively used worldwide, and its safety has been proven. Herein, we report a case of an acute necrotic disorder in the small intestine post‐COVID‐19 vaccination. The patient developed severe abdominal pain the day after the first vaccination. Contrast‐enhanced computed tomography showed extensive ileum wall thickening and ascites. Colonoscopy revealed a ring‐shaped ulcer and stricture in the terminal ileum. Ileocecal resection was performed, and the patient did not have further episodes of a necrotic disorder in the small intestine. Although it is unknown if this event is associated with vaccination, and this occurrence also does not outweigh the efficacy and safety of the Pfizer‐BioNTech COVID‐19 vaccine, gastroenterologists need to be aware of this rare case, given its noteworthy timing.
Seasonal and spatial variability of zooplankton diversity in the Poyang Lake Basin using DNA metabarcoding
Authors: Qiu Xuemei , Liu Xiongjun , Lu Quanfeng , Chen Jinping , Liang Tao , Wang Weikai , Ouyang Shan , Zhou Chunhua , Wu Xiaoping 
Published: June 2022

AbstractFreshwater ecosystems face multiple threats to their stability globally. Poyang Lake is the largest lake in China, but its habitat has been seriously degraded because of human activities and natural factors (e.g. climate change), resulting in a decline in freshwater biodiversity. Zooplankton are useful indicators of environmental stressors because they are sensitive to external perturbations. DNA metabarcoding is an approach that has gained significant traction by aiding ecosystem conservation and management. Here, the seasonal and spatial variability in the zooplankton diversity were analyzed in the Poyang Lake Basin using DNA metabarcoding. The results showed that the community structure of zooplankton exhibited significant seasonal and spatial variability using DNA metabarcoding, where the community structure was correlated with turbidity, water temperature, pH, total phosphorus, and chlorophyll‐a. These results indicated habitat variations affected by human activities and seasonal change could be the main driving factors for the variations of zooplankton community. This study also provides an important reference for the management of aquatic ecosystem health and conservation of aquatic biodiversity.
Visible Light‐Mediated Metal‐Free Chlorodifluoromethylation of Arenes and Heteroarenes by a Hypervalent Iodine EDA Complex
Authors: Lin Daniel , Krishnamurti Vinayak , Prakash G. K. Surya 
Published: June 2022

AbstractA novel EDA complex comprised of a bis(chlorodifluoroacetoxy)iodoarene and 1,3,5‐trimethoxybenzene is described, which enables the direct radical C(sp2)−H chlorodifluoromethylation of arenes and heteroarenes under monochromatic visible‐light irradiation. The procedure is mild, operationally simple, and utilizes commercially available reagents. The developed conditions demonstrate compatibility with a host of commonly encountered functionalities and biologically relevant scaffolds, whilst showcasing the post‐functionalization capabilities of the −CF2Cl moiety. Various mechanistic studies were performed to explore the EDA complex and radical generation pathway.
Acute Oral Toxicity of Nonfluorinated Fire-Fighting Foams to Northern Bobwhite Quail (Colinus virginianus)
Authors: Hossain Farzana , Dennis Nicole M. , Subbiah Seenivasan , Karnjanapiboonwong Adcharee , Guelfo Jennifer L. , Suski Jamie , Anderson Todd A. 
Published: June 2022

Abstract
Long-chain per- and poly-fluoroalkyl substances (PFAS) have been the active ingredients in firefighting foams for more than 50 years. Due to their extreme persistence, regulatory agencies are concerned about their potential adverse environmental and health impacts. Recently, nonfluorinated chemical constituents have been proposed for use in fire-fighting foams in an effort to reduce the potential negative impacts of PFAS on terrestrial and aquatic flora and fauna. However, it is important to also determine the potential ecotoxicity of these nonfluorinated foam products, because we have little toxicological information for many of them. In preparation for a chronic study, we conducted an acute (24-h) oral toxicity test in northern bobwhite quail (Colinus virginianus) using six different fluorine-free foams; five were commercial foams (BioEx ECOPOL A, Fomtec Enviro USP, National Foam Avio Green KHC, National Foam NFD 20-391, and Solberg Re-Healing Foam), and one was an experimental foam (NRL 502W). A short-chain PFAS-based foam (Buckeye Platinum Plus C6) was also evaluated for comparative purposes. Groups of five birds were initially pseudogavaged with a volume of each product corresponding to a “limit” (the highest exposure concentration expected to occur environmentally). Only one bird (1 of 35) died during the limit test, indicating that all seven products have an acute median lethal dose in adult quail at or above the limit (~1500 mg/kg body wt). Environ Toxicol Chem 2022;41:2003–2007. © 2022 SETAC
Outage probability minimization based power control and channel allocation in underlay D2D‐NOMA for IoT networks
Authors: Jose Justin , Agarwal Anirudh , Bhatia Vimal , Krejcar Ondrej 
Published: June 2022

AbstractThe emergence of Internet‐of‐Things (IoT) aims to improve modern life by inter‐connecting many smart devices, technologies, and applications. It, however, drastically increases mobile traffic and requires large wireless spectrum. Therefore, for a better spectrum utilization to support this massive connectivity along with low latency and close proximity based communication, non‐orthogonal multiple access enabled underlay device‐to‐device (D2D‐NOMA) is envisioned as a key technology for IoT deployment. Hence, in this work, we consider multiple IoT clusters communicating via underlay D2D‐NOMA in an uplink cellular network, with the objective of minimizing the outage probability (OP) while allocating resources to the clusters. Specifically, for each cluster, we formulate the optimization problem of OP‐based power control with fixed channel allocation (PCCA) and solve it using particle swarm optimization (PSO). Additionally, we prove the convexity of PCCA problem and obtain closed‐form expressions at high SNR. Further, we propose a novel OP‐aware channel allocation (OPCA) algorithm to enhance the overall D2D network outage performance. The results are numerically validated and an average performance improvement of 31% and 51% is observed over the two conventional schemes namely fixed power allocation and orthogonal multiple access enabled D2D, respectively.
Default Mode Network quantitative diffusion and resting‐state functional magnetic resonance imaging correlates in sporadic Creutzfeldt‐Jakob disease
Authors: Paoletti Matteo , Caverzasi Eduardo , Mandelli Maria Luisa , Brown Jesse A. , Henry Roland G. , Miller Bruce L. , Rosen Howard J. , DeArmond Stephen J. , Bastianello Stefano , Seeley William W. , Geschwind Michael D. 
Published: June 2022

AbstractGrey matter involvement is a well‐known feature in sporadic Creutzfeldt–Jakob disease (sCJD), yet precise anatomy‐based quantification of reduced diffusivity is still not fully understood. Default Mode Network (DMN) areas have been recently demonstrated as selectively involved in sCJD, and functional connectivity has never been investigated in prion diseases. We analyzed the grey matter involvement using a quantitatively multi‐parametric MRI approach. Specifically, grey matter mean diffusivity of 37 subjects with sCJD was compared with that of 30 age‐matched healthy controls with a group‐wise approach. Differences in mean diffusivity were also examined between the cortical (MM(V)1, MM(V)2C, and VV1) and subcortical (VV2 and MV2K) subgroups of sCJD for those with autopsy data available (n = 27, 73%). We also assessed resting‐state functional connectivity of both ventral and dorsal components of DMN in a subset of subject with a rs‐fMRI dataset available (n = 17). Decreased diffusivity was predominantly present in posterior cortical regions of the DMN, but also outside of the DMN in temporal areas and in a few limbic and frontal areas, in addition to extensive deep nuclei involvement. Both subcortical and cortical sCJD subgroups showed decreased diffusivity subcortically, whereas only the cortical type expressed significantly decreased diffusivity cortically, mainly in parietal, occipital, and medial‐inferior temporal cortices bilaterally. Interestingly, we found abnormally increased connectivity in both dorsal and ventral components of the DMN in sCJD subjects compared with healthy controls. The significance and possible utility of functional imaging as a biomarker for tracking disease progression in prion disease needs to be explored further.
The effect of learning management system on ICU nurses' sustained learning about safe blood transfusion: A quasi‐experimental study
Authors: Falaki Mojgan , Ahmadinejad Mehdi , Razban Farideh , Najafipour Mohammad A. , Asadi Neda 
Published: June 2022

AbstractBackground and AimsTransfusion of blood products is an important part of the health care system. Since one of the significant challenges in nursing education is using an effective method that provides depth and stability of learning, this study aimed to assess using a learning management system (LMS) for intensive care unit (ICU) nurses' sustained learning about safe blood transfusion in southeast Iran.MethodsThis was a quasi‐experimental study in southeast of Iran in 2021 in two groups, control and intervention. Two ICUs received lecture training and two ICUs received LMS. The samples 80 nurses were selected by random convenience sampling. In the LMS group, the educational content was presented using Edmodo software. The control group received no intervention except for traditional education (lecture). The questionnaires were completed immediately, 1 month, and 3 months after the intervention.ResultsThe mean score of knowledge immediately, 1 month and 3 months after the intervention were 9.53 ± 1.82, 9.46 ± 1.85, and 8 ± 2.94, in the lecture group and 8.91 ± 1.59, 9.47 ± 2.46, and 8.09 ± 1.94 in the LMS group, respectively. The mean score of practice immediately, 1 and 3 months after the intervention were 59.69 ± 39.6, 70.63 ± 7.4, and 83.70 ± 43.6 in the lecture group and 45.68 ± 55.5, 67.69 ± 4.56, and 35.70 ± 46.4 in the LMS group, respectively. The mean score of knowledge and practice in the two groups significantly increased immediately and 1 month and 3 months after intervention (p < 0.001). No significant difference was observed between the two groups (p > 0.05).ConclusionsLMS method has a significant effect on improving the sustained learning of ICU nurses, and no significant difference was observed between the two educational methods. Hence, considering the busy work schedule of nurses, lack of staff, and the impossibility of physical attendance in lecture classes, it seems that LMS‐based methods are appropriate alternatives to traditional learning methods.