bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biochemical analyses for dental age estimation: a review
Authors: Pillalamarri Maitreyi , Manyam Ravikanth , Pasupuleti Swetha , Birajdar Smita , Akula Satya Tejaswi 
Published: January 2022

Abstract
Background
For various legal and forensic scenarios, establishing an individual’s age, both living and dead, plays a crucial role. Various morphological, radiographic, and molecular methods can be used for age estimation. In children and adolescents, age estimation is based on the established developmental stages. However, in adults, where the development ceases into maturation, the degenerative changes play a role in determining the age.

Main body of the abstract
In the natural aging process, several molecular changes occur most commonly in the long-living proteins and hard tissues like the teeth and bone. These molecular changes gradually lead to alterations in several organs and organ systems, which can be quantified and correlated with age, including aspartic acid racemization, collagen crosslinks, advanced glycation-end products, and mitochondrial DNA mutations.

Short conclusion
Among the above methods, the racemization of aspartic acid can be considered as the most precise method. The main advantage of using aspartic acid racemization is that the sample can be collected from tissues (teeth) protected from various environmental and nutritional factors. If all the confounding factors are stable, the utilization of advanced glycation-end products can also be considered valuable. Environmental factors like lead accumulations may also help determine the age. However, further studies need to be conducted, focusing on providing a more standardized method. This review provides a concise summary of the biochemical techniques that can be used for estimation of age.
Considerations on Integrating Prostate-Specific Membrane Antigen Positron Emission Tomography Imaging Into Clinical Prostate Cancer Trials by National Clinical Trials Network Cooperative Groups
Authors: Schöder Heiko , Hope Thomas A. , Knopp Michael , Kelly William K. , Michalski Jeff M. , Lerner Seth P. , Tawab-Amiri Abdul , Mann Bhupinder S. , Lin Daniel W. , Yu Evan Y. , Chen Ronald C. , Beach Gillian C. , Reeves Steven A. ,   Members of the Working Group, Shankar Lalitha K. 
Published: January 2022

PURPOSE As prostate-specific membrane antigen (PSMA) positron emission tomography (PET) becomes increasingly available in the United States, the greater sensitivity of the technology in comparison to conventional imaging poses challenges for clinical trials. The NCI Clinical Imaging Steering Committee (CISC) PSMA PET Working Group was convened to coordinate the identification of these challenges in various clinical scenarios and to develop consensus recommendations on how best to integrate PSMA PET into ongoing and upcoming National Clinical Trials Network (NCTN) trials. METHODS NCI CISC and NCI Genitourinary Steering Committee members and leadership nominated clinicians, biostatisticians, patient advocates, and other imaging experts for inclusion in the PSMA PET Working Group. From April to July 2021, the working group met independently and in conjunction with the CISC to frame challenges, including stage migration, response assessment, trial logistics, and statistical challenges, and to discuss proposed solutions. An anonymous, open-ended survey was distributed to members to collect feedback on challenges faced. Representatives from each NCTN group were invited to present an overview of affected trials. From these discussions, the consensus document was developed and circulated for the inclusion of multiple rounds of feedback from both the Working Group and CISC. RESULTS The current consensus document outlines the key challenges for clinical prostate cancer trials resulting from the increasing availability of PSMA PET. We discuss implications for patient selection and definition of end points and provide guidance and potential solutions for different clinical scenarios, particularly with regard to best practices in defining eligibility criteria and outcome measures. RECOMMENDATIONS This article provides guidance regarding clinical trial design and conduct, and the interpretation of trial results.
Severe Hypoglycemia Increases Dementia Risk and Related Mortality: A Nationwide, Population-based Cohort Study
Authors: Han Eugene , Han Kyung-do , Lee Byung-Wan , Kang Eun Seok , Cha Bong-Soo , Ko Seung-Hyun , Lee Yong-ho 
Published: January 2022

Abstract

Context
There are few studies focused on the relationship between hypoglycemia and new-onset dementia in patients with type 2 diabetes and no study regarding mortality of dementia after hypoglycemia.

Objective
We investigated the effect of severe hypoglycemia on dementia subtypes and its relation to overall mortality in patients with type 2 diabetes.

Methods
We evaluated incident dementia, including Alzheimer disease and vascular dementia, among health checkup participants aged 40 years or older in the National Health Insurance System in Korea from January 2009 to December 2015. Episodes of severe hypoglycemia were examined for 3 years before the date of the health checkup.

Results
Among 2 032 689 participants (1 172 271 men, 860 418 women), 14 443 (0.7%) experienced severe hypoglycemia, during a mean follow-up period of 6.9 ± 1.7 years. Individuals in the severe hypoglycemia group were more likely to be diagnosed with dementia compared to individuals without severe hypoglycemia (23.3% vs 7.3%; P &lt; .001) and the overall incidence of Alzheimer disease was higher than vascular dementia. Dementia risk rose with increasing number of severe hypoglycemic episodes (1 episode [hazard ratio (HR) = 1.54; 95% CI, 1.48-1.60], 2 or more episodes [HR = 1.80; 95% CI, 1.66-1.94]). Overall mortality was higher in participants with dementia, but without severe hypoglycemia (HR = 2.03; 95% CI, 1.96-2.10) and severe hypoglycemia, but without dementia (HR = 4.24; 95% CI, 4.29-4.40), and risk of death was highest in those with both severe hypoglycemia and dementia (HR = 5.08; 95% CI, 4.83-5.35).

Conclusion
Severe hypoglycemia is associated with dementia, especially Alzheimer disease and mortality; together, they have an additive effect on overall mortality.
What Was Tragedy during the Haitian Revolution?
Authors: Murphy Kieran M. 
Published: January 2022

AbstractContemporary actors and, later, historians and critics have long compared the Haitian Revolution to a tragic play. But the model of tragedy they invoke has changed over time. Today the best-known example comes from The Black Jacobins (1963), in which C. L. R. James narrates the events of the Revolution through the lens of a Hegelian definition of tragedy. David Scott has championed James’s “tragic mode of history” for political reasons, arguing that it is better suited to address the challenges of the postcolonial present. But a tragic mode of history can be of use for the postcolonial present only if it is firmly grounded in the world-changing events that it is supposed to illuminate. It should build on what tragedy was in the milieu of Toussaint Louverture and the slave rebels. To lay the groundwork for this critical shift, this essay traces how tragic performances and history intersected during the Revolution and shows how radicalized versions of Voltaire’s Roman-themed tragedies and Afro-Caribbean mythology and rituals played a prominent part in the fight for equality.
Domesticating Decadence: Joris-Karl Huysmans, Pierre Louÿs, and Their Invisible English Translators
Authors: Valentine Colton 
Published: January 2022

AbstractDecadence eludes definition, but critics tend to concur on the movement’s transgressive and uncommercial status in the British literary field. This essay questions those associations by exploring a current of archetypal decadent French novels translated by and marketed to a mainstream Anglophone audience: Joris-Karl Huysmans’s En Route (1895, trans. 1896) and La cathédrale (1898, trans. 1898) and Pierre Louÿs’s Aphrodite: Mœurs antiques (1896, trans. 1900 and 1906) and La femme et le pantin (1898, trans. 1908). By reading letters, memoirs, and prefaces alongside periodical reviews and a publisher’s archive, the essay sheds light on the novels’ invisible translators and reveals the fiscal and legal viability of “domesticated decadence.” Doing so models how translation studies and book-historical methods can revise deep-set tenets of literary history. These “poisonous” epitomes of the fin de siècle in fact circulated freely across the Channel, reaching more than the happy few.
Microwave-exfoliated Graphene Oxide for High Voltage “Water-in-Salt” Electrolyte-based Supercapacitor
Authors: Yu Sangho , Sano Hideaki , Zheng Guobin , Tanabe Shuji 
Published: January 2022

Abstract
Exfoliated and reduced graphene oxide (MEGO) was fabricated by rapid microwave irradiation. When MEGO was used as the electrode of 17 m NaClO4 “water-in-salt” (WIS) electrolyte-based supercapacitors, the cell exhibited stable double layer capacitant behavior up to 2.5 V, much higher than the electrochemical stable window of water. The MEGO exhibited high energy density of 22 Wh/kg at a power density of 12.5 kW/kg, attributable to fast motion of ion clusters in the large space of exfoliated nanosheets in MEGO.
Single-molecule Fluorescence Kinetic Sandwich Assay Using a DNA Sequencer
Authors: Kawai Kiyohiko , Fujitsuka Mamoru 
Published: January 2022

Abstract
Using an ATP split aptamer as a model system, a single-molecule fluorescence kinetic sandwich assay was performed on zero-mode waveguides (ZMWs). A high-throughput parallel analysis of 150250 ZMWs was demonstrated by using an RSII+ (Pacific Biosciences) third-generation DNA sequencer.
An exploration of the consequences of, and coping with loneliness in an ageing intellectual disability population
Authors: Wormald Andrew , McCallion Philip , McCarron Mary 
Published: January 2022

Background: Loneliness has been associated with hypervigilance and sad passivity. The physiological and psychological reactions of people with an intellectual disability to loneliness have never been investigated. This research aims to explore the outcomes of loneliness for an ageing intellectual disability population. Methods: In Ireland, data from a nationally representative data set of people aged over 40 years with an intellectual disability (N=317) was applied to a social environment model that describes the effects of loneliness in five pre-disease pathways health behaviours, exposure to stressful life events, coping, health and recuperation. The data was tested through chi-squared, ANCOVA and binary logistic regression. Results: Being lonely predicted raised systolic blood pressure (A.O.R=2.051, p=0.039), sleeping difficulties (AOR=2.526, p=0.002) and confiding in staff (AOR=0.464 p=0.008). Additionally, participants who did moderate activity had significantly higher loneliness scores (F=4.171, p<0.05). Conclusions: The analysis supports the concept of hypervigilance in older people with an intellectual disability and limited support for the use of coping mechanisms that differ from those found in the wider population. Future research needs to investigate the longitudinal relationships between loneliness and health.
Work and its transformations: from statism-based work to the Gig Economy
Authors: Krzyminiewska Grażyna 
Published: January 2022

Motivation: Work as a socio-cultural and -economic phenomenon in the process of Poland’s economic transformation within the last thirty years requires special analyses due to its central role both in individual and social terms. To a significant extent, the traditional approach is based on unhelpful separation of economic determinants from the social system as a whole, which is with detriment to the ability to investigate economic processes. Economic phenomena are not the effect of actions of unrelated individuals and their decisions based on rational calculations, but also arise out of the values rooted in their way of thinking and demonstrated through culture.
Aim: This paper is aimed at describing the evolution of work in the context of the changes occurring on the labour market which result from the transformation of these institutions and of the economic culture of Poles. The aim may be achieved by assuming that the experience of the so-called ‘cultural turn’, a term which perfectly suits to describe the transformation process, requires interest to be taken also in phenomena occurring in everyday life, such as values, attitudes or cultural patterns. The transformation of work and of its meaning for development will be subject to descriptive and comparative analysis in two aspects: (1) with regard to the shift from statism-based economy to flexible forms of employment and the occurrences that accompany that shift and (2) in terms of global economic and technological changes in this regard.
Results: The analyses carried out allowed to describe the changes in the Polish society observed in the area of work. The stages of the changes are identified, and new trends are specified which emerge under the impact of global development and their consequences for the economy and the society.
Unemployment as a determinant of local service-oriented entrepreneurship: a case study of Poland
Authors: Wosiek Małgorzata 
Published: January 2022

Motivation: Unemployment is an important entrepreneurship determinant which is captured by the unemployment push/pull hypotheses. Those issues remain underexplored, with only few studies investigating the relationship between unemployment and the sector structure of entrepreneurship, while considering the specificity of the local economy.
Aim: The main goal of the study is to assess the impact of local unemployment rate on the number of newly registered service businesses in Poland, taking into account both the heterogeneity of that sector and the specificities of local economies in 2003–2018.
Results: The research results show that in Poland growing unemployment contributed to the increasing registration of new service businesses, which empirically supports the unemployment-push hypothesis. Both the occurrence and the intensity of the unemployment-push effect were conditioned by territorial factors, with the higher elasticity of entrepreneurship in relation to unemployment changes in lagged local units.
Peculiarities of neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats
Authors: Hrytsak Myroslava , Popovych Dariya , Badiuk Nataliya , Hrytsan Ivanna 
Published: January 2022

Background. Earlier we found that the newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have similar neuroendocrine and metabolic effects on healthy old female rats significantly different from daily water. The aim of this study is to elucidate the effects of these mineral waters on the neuroendocrine status and metabolism of these animals. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the control group for 6 days injected a tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The day after the completion of the drinking course in all rats, at first, assessed the state of autonomous regulation by parameters of the HRV. The plasma levels of the hormones of adaptation were determined: corticosterone, triiodothyronine and testosterone (by the ELISA) as well as electrolytes: calcium, magnesium, phosphates, chloride, sodium and potassium; nitric metabolites: creatinine, urea, uric acid, medium molecular polypeptides, bilirubin; lipid peroxidation products and antioxidant enzymes, as well as cholesterol, amylase and glucose. Most of the listed parameters of metabolism were also determined in daily urine. In the adrenals the thickness of glomerular, fascicular, reticular and medullar zones was measured. Results. To identify exactly those parameters, the set of which all four groups of animals differ significantly from each other, the information field of the registered parameters was subjected to discriminant analysis. The program included in the model 8 endocrine and 16 metabolic parameters, information about which is condensed into three roots. The first root reflects directly the SOD and corticosterone and inversely the reticular zone as well as plasma uric acid and glucose. The second root contains information about Nap/Kp ratio, natrihistia, amylasemia, magnesiumuria as well as inversely about kaliemia. The third root reflects directly the triiodothyronine, parathyroid activity, plasma Ca, natriuria and chloriduria as well as urine malondyaldehide. Inversely displays the root information about the testosterone, Ku/Nau ratio, glomerular zone, plasma katalase and Na as well as uricosuria and amylasuria. In the information space of the three discriminant roots, all four groups are quite clearly distinguished. Classification accuracy is 94% (three errors). Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets resort have specific endocrine and metabolic effects on healthy old female rats with weekly use. This provides a basis for preclinical studies.
A systematic review and meta-analysis uncovering the relationship between alcohol consumption and sickness absence. When type of design, data, and sickness absence make a difference
Authors: S. Hashemi Neda , Skogen Jens Christoffer , Sevic Aleksandra , Thørrisen Mikkel Magnus , Rimstad Silje Lill , Sagvaag Hildegunn , Riper Heleen , Aas Randi Wågø 
Published: January 2022

AimEarlier research has revealed a strong relationship between alcohol use and sickness absence. The aim of this review was to explore and uncover this relationship by looking at differences in type of design (cross-sectional vs. longitudinal), type of data (self-reported vs. registered data), and type of sickness absence (long-term vs. short term).MethodSix databases were searched through June 2020. Observational and experimental studies from 1980 to 2020, in English or Scandinavian languages reporting the results of the association between alcohol consumption and sickness absence among working population were included. Quality assessment, and statistical analysis focusing on differences in the likelihood of sickness absence on subgroup levels were performed on each association, not on each study. Differences in the likelihood of sickness absence were analyzed by means of meta-analysis. PROSPERO registration number: CRD42018112078.ResultsFifty-nine studies (58% longitudinal) including 439,209 employees (min. 43, max. 77,746) from 15 countries were included. Most associations indicating positive and statistically significant results were based on longitudinal data (70%) and confirmed the strong/causal relationship between alcohol use and sickness absence. The meta-analysis included eight studies (ten samples). The increased risk for sickness absence was likely to be found in cross-sectional studies (OR: 8.28, 95% CI: 6.33–10.81), studies using self-reported absence data (OR: 5.16, 95% CI: 3.16–8.45), and those reporting short-term sickness absence (OR: 4.84, 95% CI: 2.73–8.60).ConclusionThis review supports, but also challenges earlier evidence on the association between alcohol use and sickness absence. Certain types of design, data, and types of sickness absence may produce large effects. Hence, to investigate the actual association between alcohol and sickness absence, research should produce and review longitudinal designed studies using registry data and do subgroup analyses that cover and explain variability of this association.
A Critical Review of Open Innovation in SMEs: Implementation, Success Factors and Challenges
Authors: Wibisono Eristian 
Published: January 2022

<p><strong><em>Abstract</em></strong></p><p><em>This literature review explores the Open Innovation of SME companies, their application, success factors, impact, and challenges. The theoretical framework is built starting from the definition, a critical pillar, and Open Innovation in SME companies. The main factor in the Open Innovation process stage is finding innovative ideas and establishing network access with the external environment. Balanced, systematic, and thorough collaboration is the key to this process. Although European scholars have done it quite a lot, the study of literature on Open Innovation in SMEs still could continue to be developed. Several research results were found in studies conducted in developing countries such as China, Taiwan, and Korea, distinguishing them from similar studies in Europe.</em></p><p><strong><em>Keywords:</em></strong><em> <em>innovation; SMEs; technology; entrepreneurship; open innovation</em></em></p>
The Reorientation of Thailand’s National R&D Programmes - Limits and Challenges
Authors: Jutarosaga Anittha , Hengjan Yupadee , Charoenpornpattana Santi , Jitvanichphaibool Kommate 
Published: January 2022

<p>Since 2016 Thailand has recognised a significant transition in research and innovation policy, with government increasingly acknowledging the importance of national R&amp;D programmes and favourable institutional conditions as determinants to overcome middle income trap. Drawing a lesson-learned from successful experiences of South Korea and Japan, the Thai government decided to experiment the national large-scaled mission-oriented R&amp;D programme, known as ‘Spearhead R&amp;D Programme’. This novel innovation financing scheme was designed to accelerate the commercialisation and economic impact of R&amp;D outputs. From the outset, it was clear that the outcome and impact of Spearhead R&amp;D Programme was yet to be realized. The purpose of this paper is to investigate the reorientation of Thailand’s research and innovation landscape with the focus on the efficiency of operation in relation to the objective of the Spearhead R&amp;D Programme. It is found that the Spearhead R&amp;D Programme is equipped with four novel conceptual and operational features including strategic national STI agenda, R&amp;D commercialization, multi-year budget allocation and proactive research management. Yet, there were also potential limits and challenges that need to be addressed to move the Programme towards greater sectoral contribution with open innovation and flexibility in policy learning.</p><p> </p><p>Keywords: Research &amp; Innovation Reform, Mission-oriented R&amp;D Programme, Policy Experiment, Catch-up, R&amp;D Commercialisation, Thailand</p>
Pandemia COVID-19 e Ações do Núcleo Ampliado de Saúde da Família e Atenção Básica na Rede SUS
Authors: Coelho Otamares Castro Simões , Ferreira Anelisa Terrola Martins , Mendonça Raquel de Deus 
Published: January 2022

O Núcleo Ampliado de Saúde da Família e Atenção Básica (NASF-AB) visa ampliar as ações desenvolvidas pela Estratégia de Saúde da Família. Entretanto, suas atividades sofreram alterações temporárias, devido à pandemia da COVID-19. O objetivo deste trabalho é descrever as atividades e serviços realizados pelos profissionais do NASF-AB de uma regional na rede SUS-BH durante a pandemia de SARS-CoV-2. Trata-se de um estudo transversal com amostra de conveniência em Belo Horizonte-MG. Os dados foram coletados por um questionário online autoaplicado. Participaram 38 profissionais, dos quais 71% atuavam na Atenção Básica há mais de 5 anos. Na pandemia, observou-se falta de acesso a treinamentos (71%) e equipamentos tecnológicos (53%) para acompanhamento dos usuários. Os grupos operativos foram 100% suspensos e 90% relataram acesso aos Equipamentos de Proteção Individual. Apesar dos desafios que dificultaram a reorganização dos trabalhos e o acompanhamento dos usuários durante eventos excepcionais, o NASF-AB apresenta-se como uma potente estratégia de cuidado.