bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can glucagon-like peptide-1 receptor agonists cause acute kidney injury? An analytical study based on post-marketing approval pharmacovigilance data
Authors: Dong Shichao , Sun Chuan 
Published: December 2022

Clinical studies after marketing have shown that the use of glucagon-like peptide-1 receptor agonist(GLP-1RA) may lead to acute kidney injury(AKI). However, few epidemiological studies have investigated the risk, clinical features, and outcomes of AKI caused by different GLP-1RA. In this study, Adverse Event Reporting System (FAERS) data were used to compare the association between different GLP-1RA and AKI in the real world.MethodsFAERS data from January 2004 to December 2021 were mined using disproportionality analysis and Bayesian analysis to determine the correlation between different GLP-1RA and AKI, and the onset time, mortality, and hospitalization rate of different GLP-1RA were analyzed.ResultsWe identified 2670 cases of AKI events associated with GLP-1RA, of which liraglutide was the most commonly reported (34.98%). The patients with AKI were mainly males (47.94%), and the age group was mainly 45-84 years old (73.15%). obese patients with weight more than 99kg (24.42%) were more likely to have AKI. According to different signal mining methods, reporting odds ratio (ROR) (1.50, 95% confidence interval =1.41-1.60) and Bayesian confidence Propagation neural network (0.57, 95% confidence interval =0.54), liraglutide was more strongly associated with AKI than other GLP-1RA. The median time to onset of AKI was 63 days [quartile range (IQR): 15-458.5 days]. In addition, the hospitalization rate and fatality rate of patients with GLP-1RA-related AKI were 45.28% and 4.23% respectively.ConclusionsBased on the data in the FAERS database, we analyzed the risk, onset time, and adverse reaction outcomes of GLP-1RA-induced AKI in detail. The results showed that liraglutide had the highest risk of AKI. From the early stage of treatment, we need to monitor patients’ renal function regularly, especially for patients with high kidney risks such as obesity and age.
Genetic evidence of differential dispersal pattern in the Asiatic wild dog: Comparing two populations with different pack sizes
Authors: Modi Shrushti , Mondol Samrat , Ghaskadbi Pallavi , Nigam Parag , Habib Bilal 
Published: December 2022

IntroductionDispersal is a multi-causal, crucial life-history event in shaping the genetic and behavioral structure of mammals. We assessed the dispersal pattern of dholes aka Asiatic wild dog (Cuon alpinus), a social monogamous mammal at two tiger reserves of Maharashtra with different degrees of pack size and competition with tigers i.e. Tadoba-Andhari (TATR, smaller pack size, higher tiger density) and Nawegaon-Nagzira (NNTR, larger pack size, lower tiger density).MethodsWe used the microsatellite data of 174 individual genotypes (98 males and 67 females) to assess the dispersal pattern of dholes from two populations with varying pack size, tiger density, and landscape connectivity using gene flow as a proxy. We compared the population structure, pairwise F statistics, assignment index, and relatedness across a spatial scale.Results and discussionOverall, the results suggested a difference in sex-bias dispersal pattern for the two sub-populations, exhibiting significant results for female-biased dispersal in the TATR population with a smaller pack size and higher tiger density. Our study highlights the variability in sex-biased dispersal patterns in two different populations which could be the consequence of different variables such as pack size, tiger density, and geographical scale. The study warrants further quantitative investigation including several factors such as individual behavior, pack composition, pack size, tiger density, etc. In the present Anthropocene era, determining the sex bias in dispersal patterns for a short-range, pack-living carnivore will help in devising an effective conservation management plan for their long-term survival.
Effective natural inhibitors targeting granzyme B in rheumatoid arthritis by computational study
Authors: Wang Xinyu , Jiang Ye , Zhou Pengcheng , Lin Liangxin , Yang Yilin , Yang Qifan , Zhang Jiting , Zhu Dong 
Published: December 2022

BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by erosive arthritis, and current treatments for RA fall short of the outcomes expected by clinicians and patients.ObjectivesThis study aimed to identify novel therapeutic and prognostic targets in RA at the genomic level and to screen desirable compounds with potential inhibitory effects on GZMB.MethodsWe performed differential gene analysis on GSE55235 and GSE55457 from Gene Expression Omnibus (GEO) and then obtained the intersection of the two differentially expressed genes (DEGs) lists by drawing Venn diagrams. Then we performed protein-protein interaction (PPI) network analysis, Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis on the DEGs of the intersection. Next, we downloaded the crystal structure of Granzyme B (GZMB). Molecular docking technology was used to screen potential inhibitors of GZMB in subsequent experiments, and we then analyzed the toxicity and water solubility of these potential inhibitors for future drug experiments. Finally, whether the docking of these small molecules with GZMB is stable is tested by molecular dynamics.ResultsA total of 352 mutual DEGs were identified. Twenty hub genes were obtained according to PPI network analysis, among which the GZMB gene attracted the attention of our research. Three potent natural compounds, ZINC000004557101, ZINC000012495776, and ZINC000038143593, bound to GZMB, show better binding affinity. Furthermore, they are predicted to own low Ames mutagenicity, developmental toxicity potential, rodent carcinogenicity, and high tolerance to cytochrome P4502D6. Molecular dynamics simulations show that ZINC000004557101 and GZMB have more advantageous potential energy and can exist stably in a natural environment. Moreover, we finally verified the inhibitory effect of ZINC000004557101 on granzyme B by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and Western blotting experiment.ConclusionRA patients showed increased GZMB expression. ZINC000004557101 is a potential drug targeting GZMB for treating RA.
The research frontier of cesarean section recovery: A bibliometric analysis
Authors: Zhao Lizheng , Wei Hong 
Published: December 2022

BackgroundCesarean section (CS) has become an effective means to solve dystocia and some obstetric complications, and to save the lives of women and perinatal women. Disparities in quality obstetric care and rehabilitation in CS result from differences in health care systems across regions, and more scientific and reasonable rehabilitation programmes and management measures will benefit more parturient and newborns worldwide who must take CS. In this study, we performed a bibliometric analysis to collect a graphical representation of the CS recovery.MethodsA total of 995 documents of CS recovery were retrieved from the Web of Science Core Collection (WOSCC) on December 31, 2021, and then VOS viewer 1.6.18 was used for visual analysis.ResultsOver the last 20 years, the researches of CS recovery have gradually increased and it will continue to grow in the next period. Anesthesia and Analgesia is the most popular journal in CS recovery. Most of the representative achievements are concentrated in the relevant institutions of European and American countries, Brendan Carvalho and Ian J. Wrench are among the outstanding scholars in this field, but the overall outcome is limited by limited regional work and lack of broad cooperation and representation. “CS,” “surgery,” “management,” “recovery,” “enhanced recovery,” and “risk factors” are high frequency keywords, and there is a close relationship between “management” and “enhanced recovery” around the CS and they also become one of the key factors to regulate the condition of patients.ConclusionThis work firstly analyzed the research condition of CS recovery by a bibliometric analysis. According to the practice guideline, it produces some outstanding representative productions, which involves enhanced recovery after surgery (ERAS) and will continue to be the focus of researchers. More substantive research articles and large-scale clinical studies may greatly enhance the scientific value, and it is necessary to strengthen the ERAS guideline and cooperation between researchers, generate broader consensus and results, and ultimately provide help for CS recovery.
Effects of stent shape on focal hemodynamics in intracranial atherosclerotic stenosis: A simulation study with computational fluid dynamics modeling
Authors: Liu Haipeng , Liu Yu , Ip Bonaventure Y. M. , Ma Sze Ho , Abrigo Jill , Soo Yannie O. Y. , Leung Thomas W. , Leng Xinyi 
Published: December 2022

Background and aimsThe shape of a stent could influence focal hemodynamics and subsequently plaque growth or in-stent restenosis in intracranial atherosclerotic stenosis (ICAS). In this preliminary study, we aim to investigate the associations between stent shapes and focal hemodynamics in ICAS, using computational fluid dynamics (CFD) simulations with manually manipulated stents of different shapes.MethodsWe built an idealized artery model, and reconstructed four patient-specific models of ICAS. In each model, three variations of stent geometry (i.e., enlarged, inner-narrowed, and outer-narrowed) were developed. We performed static CFD simulation on the idealized model and three patient-specific models, and transient CFD simulation of three cardiac cycles on one patient-specific model. Pressure, wall shear stress (WSS), and low-density lipoprotein (LDL) filtration rate were quantified in the CFD models, and compared between models with an inner- or outer-narrowed stent vs. an enlarged stent. The absolute difference in each hemodynamic parameter was obtained by subtracting values from two models; a normalized difference (ND) was calculated as the ratio of the absolute difference and the value in the enlarged stent model, both area-averaged throughout the arterial wall.ResultsThe differences in focal pressure in models with different stent geometry were negligible (ND&lt;1% for all cases). However, there were significant differences in the WSS and LDL filtration rate with different stent geometry, with ND &gt;20% in a static model. Observable differences in WSS and LDL filtration rate mainly appeared in area adjacent to and immediately distal to the stent. In the transient simulation, the LDL filtration rate had milder temporal fluctuations than WSS.ConclusionsThe stent geometry might influence the focal WSS and LDL filtration rate in ICAS, with negligible effect on pressure. Future studies are warranted to verify the relevance of the changes in these hemodynamic parameters in governing plaque growth and possibly in-stent restenosis in ICAS.
Clinicopathological characteristics of gastrointestinal schwannomas: A retrospective analysis of 78 cases
Authors: Peng Hailing , Han Liu , Tan Yuyong , Chu Yi , Lv Liang , Liu Deliang , Zhu Hongyi 
Published: December 2022

IntroductionSchwannomas are tumors arising from Schwan cells of the neural sheath, which rarely occur in the gastrointestinal tract. The aim of the present study was to analyze the clinicopathological features and treatment outcomes of gastrointestinal schwannomas (GISs).MethodsPatients who were diagnosed with GISs in our hospital from January 2010 to December 2021 were selected. Data about demographic characteristics, clinical symptoms, treatment methods and outcomes, pathological results, and follow-up results were retrospectively collected and analyzed.ResultsA total of 78 patients with 79 GISs were included, the female-to-male ratio was 55:23, and the average age was 52.12 ± 12.26 years. One-third (26/78) of the patients were asymptomatic. A total of 79 GISs were removed, and the average size was 3.63 ± 2.03 cm (range, 0.3–10 cm). As for tumor location, 54 GISs were located in the stomach, 14 in the esophagus, 2 in the duodenum, 6 in the colorectum (4 in the colon and 2 in the rectum), and the other 3 in the small intestine. A total of 23 and 55 patients underwent endoscopic and surgical resections, respectively. Compared with surgical resection, endoscopic resection is associated with a smaller diameter, lower cost, and shorter hospital stay. Pathological results revealed that S100 was positive in all the GISs. No recurrence was noticed during a median follow-up of 45 months (range, 6–148 months).ConclusionGISs are rare gastrointestinal tumors with favorable prognoses, which are most commonly seen in the stomach and diagnosed by pathological findings with immunohistochemical staining. Surgical resection remains the standard method for removing GISs, while endoscopic resection may serve as an alternative method for selected patients with GISs and may be attempted in GISs with a diameter of &lt;3 cm and no signs of malignancy.
Tenascin-C predicts IVIG non-responsiveness and coronary artery lesions in kawasaki disease in a Chinese cohort
Authors: Li Yujie , Xu Ziqing , Wu Lin , Liang Xuecun , Zhao Lu , Liu Fang , Wang Feng 
Published: December 2022

ObjectivesTo assess the predictive value of tenascin-C (TN-C) for intravenous immunoglobulin (IVIG) non-responsiveness and coronary artery lesions (CALs) development at the acute stage of Kawasaki disease, and to build novel scoring systems for identifying IVIG non-responsiveness and CALs.MethodsA total of 261 patients in acute-stage Kawasaki disease were included. Serum samples before IVIG initiation were collected and TN-C expression levels were measured using an enzyme-linked immunosorbent assay. In addition to TN-C, another fifteen clinical and laboratory parameters collected before treatment were compared between IVIG responsive and non-responsive groups, and between groups with and without CALs. Multiple logistic regression analyses were performed to construct new scoring systems for the prediction of IVIG non-responsiveness and CALs development.ResultsIVIG non-responsive group (n = 51) had significantly higher TN-C level compared to IVIG responsive group (n = 210) (15.44 vs. 12.38 IU/L, P &lt; 0.001). A novel scoring system composed of TN-C, total bilirubin, serum sodium and albumin was established to predict IVIG non-responsiveness. Patients with a total score ≥ 2 points were classified as high-risk cases. With the sensitivity of 78.4% and specificity of 73.8%, the efficiency of our scoring system for predicting IVIG non-responsiveness was comparable to the Kobayashi system. Consistently, the group developing CALs at the acute stage (n = 42) had significantly higher TN-C level compared to the group without CALs (n = 219) (19.76 vs. 12.10 IU/L, P &lt; 0.001). A new scoring system showed that patients with elevated TN-C, platelet count ≥ 450 × 109/L, and delayed initial infusion of IVIG had a higher risk of developing CALs. Individuals with a total score ≥ 3 points were classified as high-risk cases. The sensitivity and specificity of the novel simple system for predicting CALs development were 83.3% and 74.0%, respectively, yielding a better efficiency than the Harada score.ConclusionElevated TN-C appeared to be an independent risk factor for both IVIG non-responsiveness and CALs in Chinese children with KD. Our scoring systems containing TN-C is simple and efficient in the early identification of high-risk KD cases that could benefit from more individualized medications.
High-speed ghost imaging by an unpredictable optical phased array
Authors: Sun Xuyang , Chen Hui , Qiu Bingni , Wang Gao , Xu Wanting , Luo Sheng , Yuan Yuan , Chen Bing , Zheng Huaibin , He Yuchen , Xu Zhuo 
Published: December 2022

Ghost imaging (GI) retrieves an image from the correlation between a sequence of illumination patterns on the object and their corresponding bucket detections. Traditionally, GI requires the precise information of the illumination patterns, which raises technology barriers on building a high-speed illumination source, limiting the scope of its application. In this study, we propose a high-speed GI system, which implements a self-correlation with a purely optical operation without determining illumination patterns. The light source is an optical phased array (OPA), built of a set of waveguide-type electro-optic phase modulators. The OPA is driven to randomly change the phases in every 200 ns, generating speckle patterns at a rate of 5 MHz. Although the speckle patterns are not predictable or post-determinable, with the help of the naked-eye GI scheme, the system in real time optically generates the images of the object at a frame rate of more than 1 kHz, which can be directly observed by eyes or using a camera. This method avoids acquiring the information of the illumination, thus providing a simple and easy way to realize high-speed GI. It also inspires a different way of applying OPAs to high-speed imaging.
Socio-economic factors associated with mental health outcomes during the COVID-19 pandemic in South Korea
Authors: Lee Seo Yoon , Lee Jung Jae , Lee Hooyeon 
Published: December 2022

BackgroundIndividuals are at an increased risk of adverse mental health outcomes during the COVID-19 pandemic. To reduce the impact on mental health outcomes that were induced by national-level policies, which may influence an individual at the community level, exploring the comprehensive relations between individual and environmental factors are needed. The aim is to examine socio-ecological factors associated with mental health outcomes, including depressive and anxiety symptoms, with the perspective of support to provide interventions that help the community during future disease outbreaks.MethodFrom 5 November to 20 November 2020, a cross-sectional and population-based study was conducted to assess the socio-ecological factors of mental health outcomes during the COVID-19 pandemic. A total of 1,000 participants, aged 20–69 years, in Chungnam Region, South Korea, were included in this study. Multiple linear regression models were used to examine the association between socio-ecological factors and mental health outcomes. The primary outcomes were individuals' mental health outcomes which are measured by PHQ-9 and GAD-7 scores.ResultsOf the 1,000 participants, the average PHQ-9 was 4.39, and GAD-7 was 3.21 during the COVID-19 pandemic. Specifically, the participants with moderate or severe levels of PHQ-9 and GAD-7 were 12.6 and 6.8%, respectively. Higher levels of depressive and anxiety symptoms were associated with participants who were single, reported a lower household income, had decreased support from friends or family, and increased stress from the workplace or home. In subgroup analyses by age, gender, and household income, a similar trend was reported in individual and interpersonal-level factors. There were significant associations between regional-level factors, including gross regional domestic product (GRDP), mental health institutions, psychiatrists, nurse-to-population ratios, and individuals' mental health outcomes.ConclusionThe management of depressive and anxiety symptoms of individuals during the pandemic was better explained by individual and interpersonal characteristics rather than regional-level factors, highlighting the need for more policies aimed at these lower levels.
persistência de “erros” ortográficos e a sua relação com os fenômenos fonético- fonológicos do Português Brasileiro
Authors: Carvalho Renata 
Published: December 2022

Este artigo tem o intuito de evidenciar a persistência de “erros” de ortografia na
idade adulta e a sua relação com o processo de variação linguística. Para isso, são brevemente descritos quatro dentre os diversos fenômenos fonético-fonológicos do Português Brasileiro (monotongação, ditongação, apagamento da consoante final e alçamento de vogais átonas), com base principalmente em Bortoni-Ricardo (2004), acompanhados de amostras de fala extraídas de cartas de atlas linguísticos regionais brasileiros e de exemplos de seus reflexos na escrita de crianças e adultos, além de reunir sugestões para o ensino de ortografia apresentadas por estudiosos (CAGLIARI, 1999, 2001; CIDRIM, AGUIAR, MADEIRO, 2007; LEMLE, 2000, SCLIAR-CABRAL, 2003a e 2003b; SOARES, 2006a, 2006b, entre outros) da área da aprendizagem de escrita.
Português para estrangeiros e interculturalidade: olhares para si e para o outro como processo de ressignificação cultural
Authors: Parissenti Cassiana , Ferreira de Campos Jucelina , Girardo Botelho Borges Flávia 
Published: December 2022

Este artigo objetiva analisar a interculturalidade nas aulas de Português para Estrangeiros. O estudo foi desenvolvido em um grupo multinível e multilíngue de um curso de extensão da UFMT. Teve como aporte teórico autores como Xavier Albó (2005), Bhabha (1998), Carmo (2016), entre outros. Metodologicamente, fez-se um recorte de uma das aulas, extraindo-se excertos de atividades que envolveram questões culturais nas quais os alunos se perceberem no mundo e ao mesmo tempo perceber o outro. Foram selecionados trechos em que se pode observar reflexões sobre interação, interculturalidade e identidade. Em síntese, percebeu-se que a interculturalidade demanda um jogo interacional do professor e do aprendiz e que questões sensíveis precisam ser trazidas à tona para evitar a formação de preconceitos linguísticos.

Palavras-chave: Interculturalidade. Identidade. Ensino de Línguas. PLE.
Considerações discursivas em questionários de avaliação de cursos universitários introdutórios de português no Chile
Authors: Dos Santos Marques Ana Laura , Baêta Neves Pereira Diniz Mônica 
Published: December 2022

O objetivo deste artigo é descrever, do ponto de vista discursivo, como as percepções da aprendizagem do português como uma segunda língua estrangeira (PLE) no contexto universitário chileno se correlacionam com crenças, emoções e experiências geradas
ao longo desse processo. Nossa proposta se baseia no referencial teórico-metodológico da Linguística Sistêmico Funcional para analisar as respostas obtidas em questionários de avaliação final de disciplinas. Abordamos também as noções cultura de aprender e cultura de ensinar, emoções e crenças em sala de aula. Os resultados obtidos apontam à complexidade do trabalho de planejar e conduzir aulas de PLE, posto que, no discurso, crenças, emoções e atitudes dos estudantes se manifestam em e influenciam esse processo.
Bonne nouvelle : les enseignants du fondamental estiment qu’il est important d’enseigner l’oral en classe et se sentent compétents pour le faire ! Mais certains ne le font quand même pas…
Authors: Colognesi Stéphane , Moser Vanessa , Deschepper Catherine , Hanin Vanessa 
Published: December 2022

L'objectif de cette contribution est de prolonger un état des lieux réalisé en 2019 sur l'enseignement de l'oral. Plus particulièrement, nous abordons ici : (1) les croyances des enseignants concernant l’oral et son enseignement ; (2) leur sentiment de compétence pour le faire ; (3) les situations orales pour lesquelles les enseignants estiment que les élèves doivent être compétents en langage orale ; (4) ce qu'ils disent faire concernant l'oral en classe et (5) les freins qui pourraient les empêcher de mener à bien des activités où l'oral est enseigné. En plus, nous avons voulu savoir si les réponses à ces questionnements divergeaient entre les enseignants du maternel et du primaire. Il ressort des analyses quantitatives et qualitatives menées certaines différences existent entre les enseignants des deux "groupes", mais aussi des ressemblances : ils trouvent que c'est important de travailler et enseigner l'oral en classe et ils se disent confiants dans leur capacité à l'enseigner. Leur top 4 des situations qu'il faudrait privilégier en classe est "donner une explication, expliquer un raisonnement, exprimer ses émotions et reformuler une idée". On remarque aussi un écart entre ce que les enseignants pensent, leurs conceptions de l’enseignement de l’oral en classe et leurs pratiques rapportées qui renseignent finalement peu d'oral enseigné. Cinq freins pour l'enseignement de l'oral ressortent de nos analyses.