bluuebunny/crossref_metadata_2025_split huggingface dataset:
A critical review on extraction, characteristics, physicochemical activities, potential health benefits, and industrial applications of fucoidan
Authors: Du Bin , Zhao Qiancheng , Cheng Caihong , Wang Huiying , Liu Yanfei , Zhu Fengmei , Yang Yuedong 
Published: July 2022

AbstractFucoidan is a kind of sulfated polysaccharide that consists mainly of fucose and is found in marine brown alga. Fucoidan is a major bioactive compound in brown seaweeds known to have biological activities including anticancer, anti‐inflammatory, antioxidant, anticoagulant, antithrombotic, antivirus, hypolipidemic, and immune‐modulating properties. Due to the adhesive property of fucoidan, it can increase endothelial cell adhesion and proliferation. An increasing number of investigations in the past few years have demonstrated the extraction process of fucoidan. However, the critical review of fucoidan in health benefits has been less explored. In this review, the recent advances of fucoidan were summarized. Moreover, the extraction and purification processes, the characterization of structure, as well as its physicochemical activities, biological activities, and industrial applications were discussed. This review will provide fundamental information for future investigation on controlling the structure, purity, and consistency of the fucoidan product.
Oral milrinone for management of refractory right ventricular failure in patients with left ventricular assist devices
Authors: Akhtar Waqas , Butcher Charles , Morley‐Smith Andrew , Riesgo Gil Fernando , Dar Owais , Baston Veronica , Dunning John , Lyster Haifa 
Published: July 2022

AbstractAimsWe present a single‐centre retrospective experience using oral milrinone in patients with a left ventricular assist device (LVAD) and concurrent refractory right ventricular failure.Methods and resultsAll patients implanted with LVAD between January 2013 and July 2021 from a high‐volume advanced heart failure service were reviewed. Eight patients were initiated on oral milrinone during this period. Oral milrinone was started 1.5 [inter‐quartile range (IQR) 1–2.3] years after LVAD implantation and continued for 1.2 (IQR 0.5–2.8) years. Therapeutic milrinone levels were achieved (232.2 ± 153.4 ng/mL) with 62.4 ± 18% of time within the therapeutic range. Two patients had adverse events (non‐sustained ventricular tachycardia and ventricular fibrillation effectively treated by internal cardioverter defibrillator) but did not require milrinone discontinuation. Four deaths occurred, one after transplant and three from disease progression determined to be unrelated to oral milrinone use. Three patients continue oral milrinone therapy in the community. There was no significant difference found after the initiation of oral milrinone on any of the physiological measures; however, there were trends in reduction of New York Heart Association class from 3.4 ± 0.5 to 3.0 ± 0.8 (P = 0.08), reduction of right atrial/wedge pressure from 0.9 ± 0.3 to 0.5 ± 0.2 (P = 0.08), and improvement of right ventricular stroke work index from 3.8 ± 2 to 5.8 ± 2.7 (P = 0.16).ConclusionsOral milrinone appears safe for long‐term use in the outpatient setting when combined with therapeutic monitoring in this complex medical cohort with limited management options. Further study is needed to ascertain whether this treatment is effective in reducing heart failure symptoms and admissions.
Catalytic oxidation of toluene over B‐site doped La‐based perovskite LaNixB1−xO3 (B = Co, Cu) catalysts
Authors: Qi Songya , Zhang Wanqi , Li Xiang , Wang Qing , Zhu Zerui , Zhou Ting , Wang Gaoxiang , Xie Aijuan , Luo Shiping 
Published: July 2022

AbstractA series of LaNixB1−xO3 (B = Co, Cu) perovskite catalysts were prepared by sol–gel method and applied in toluene degradation. The effects of different calcination temperatures and time on the performance of perovskite catalysts for toluene were investigated. And the CO2 yield was also carried out on as‐prepared catalysts. The results showed that a small amount of Co‐doping in B site of LaNiO3 could significantly improve its toluene degradation, while the substitution of Ni with Cu could not effectively enhance its activity. When the Ni/Co molar ratio in LaNixCo1−xO3 perovskite was 3:1, LaNi0.75Co0.25O3 catalyst exhibited the best activity, and it showed relatively short time and low temperature (T90 = 225°C, T90, corresponding to 90% conversion) for toluene degradation. Therefore, LaNi0.75Co0.25O3 catalyst has a broad prospect in the degradation of volatile organic pollutants.
Enigmatic annular landform on a Miocene planar karst surface, Nullarbor Plain, Australia
Authors: Lipar Matej , Ferk Mateja , Šmuc Andrej , Barham Milo 
Published: July 2022

AbstractThe Nullarbor Plain is a ~200,000 km2planar karst surface in southern Australia, underlain by Cenozoic shallow‐water limestones. During the Miocene the area was uplifted, and although the plain is generally considered extremely flat, locally, the geomorphology of the Nullarbor Plain retains evidence of earth surface processes across a long, middle Miocene‐to‐present time span. The accessibility of the recent 0.4 arc‐second TanDEM‐X digital elevation model (DEM) by the German Aerospace Centre motivated the search for other possible fine‐scale landforms that would previously have been unresolvable. The analysis of DEM images revealed an enigmatic annular landform with an outer diameter between 1200 m and 1300 m. It consists of a circular elevated rim and a central dome. Its morphology is distinct from other landforms observed on the plain, and cannot be readily explained as a part of known active or inferred/expected processes on the plain (e.g., fluvial, aeolian, karst, tectonic or extra‐terrestrial impact processes).More recent karst processes (dayas formation) overprinting the landform indicates the presence of the annular structure prior to dayas formation. A unique microbial boundstone facies sampled from the bed‐rock of the annular structure supports an interpretation of long‐lived, at least partial retention of a primary depositional structure. Differential carbonate deposition, especially bioherm growth, was a likely origin of the annular topographical expression of the present‐day landform and is comparable to biogenic structures in the modern day deeper Great Barrier Reef.
Carboxylation reactions for integrating CO2 capture with the production of renewable monomers
Authors: Faba Laura , Rapado Paula , Ordóñez Salvador 
Published: July 2022

AbstractResearch advances in carboxylation reactions using CO2 and light organic molecules of renewable origin are reviewed in this work, especially considering chemical catalytic approaches. Carboxylation, one of the most promising carbon capture and utilization (CCU) technologies, has a double environmental benefit, reducing greenhouse gas emissions by developing sustainable processes for commodity synthesis. The industrial interest is based on its potential use in the synthesis of biopolymer precursors from bioplatform molecules such as ethanol or furfural. Acrylic acid is obtained from ethylene (after ethanol dehydration), by a liquid phase reaction activated by organometallic catalysts. Promising yields are reported for different ligands and solvents, but a practical and sustainable implementation of these reactions is still challenging. On the other hand, the furoic acid carboxylation (furoic acid obtained by oxidation of furfural) is a solid‐gas reaction that produces 2,5furandicarboxylic acid in presence of alkaline carbonates. In this case, the economic feasibility is the main bottleneck to solve for scaling‐up, and efforts should be focused on substituting the most active alkaline carbonate (Cs) by more available alternatives. © 2022 The Authors. Greenhouse Gases: Science and Technology published by Society of Chemical Industry and John Wiley & Sons Ltd.
Uncovering neural distinctions and commodities between two creativity subsets: A meta‐analysis of fMRI studies in divergent thinking and insight using activation likelihood estimation
Authors: Kuang Changyi , Chen Jun , Chen Jiawen , Shi Yafei , Huang Huiyuan , Jiao Bingqing , Lin Qiwen , Rao Yuyang , Liu Wenting , Zhu Yunpeng , Mo Lei , Ma Lijun , Lin Jiabao 
Published: July 2022

AbstractThe dual‐process theory that two different systems of thought coexist in creative thinking has attracted considerable attention. In the field of creative thinking, divergent thinking (DT) is the ability to produce multiple solutions to open‐ended problems in a short time. It is mainly considered an associative and fast process. Meanwhile, insight, the new and unexpected comprehension of close‐ended problems, is frequently marked as a deliberate and time‐consuming thinking process requiring concentrated effort. Previous research has been dedicated to revealing their separate neural mechanisms, while few studies have compared their differences and similarities at the brain level. Therefore, the current study applied Activation Likelihood Estimation to decipher common and distinctive neural pathways that potentially underlie DT and insight. We selected 27 DT studies and 30 insight studies for retrospective meta‐analyses. Initially, two single analyses with follow‐up contrast and conjunction analyses were performed. The single analyses showed that DT mainly involved the inferior parietal lobe (IPL), cuneus, and middle frontal gyrus (MFG), while the precentral gyrus, inferior frontal gyrus (IFG), parahippocampal gyrus (PG), amygdala (AMG), and superior parietal lobe were engaged in insight. Compared to insight, DT mainly led to greater activation in the IPL, the crucial part of the default mode network. However, insight caused more significant activation in regions related to executive control functions and emotional responses, such as the IFG, MFG, PG, and AMG. Notably, the conjunction analysis detected no overlapped areas between DT and insight. These neural findings implicate that various neurocognitive circuits may support DT and insight.
Pandemics, infodemics and health promotion
Authors: White Becky , Phuong Lynette , Roach Jeremy , Teggelove Nikki , Wallace Hazel 
Published: July 2022

AbstractThe COVID‐19 pandemic and the accompanying infodemic are significant public health issues. The COVID‐19 infodemic has been prolific from early in the pandemic response, and has continued to escalate during vaccine rollout. COVID‐19 is the first pandemic in the social media era, expediting the need for effective measures to manage the high volume of information and misinformation. To address the infodemic, the World Health Organization (WHO) and others have commenced a comprehensive program of work, building capacity, raising awareness and developing new tools and methods. As part of the WHO capacity building effort, they have developed a comprehensive infodemic manager training program. The authors of this paper are Australian alumni from the first two training courses, all authors have health promotion backgrounds. Health Promotion Practitioners are uniquely positioned to build on existing skills, knowledge and reach to develop preventative strategies to help mitigate infodemics. This paper offers our combined perspectives on why the infodemic is a significant health promotion concern and the role we believe Health Promotion Practitioners can play in managing and mitigating the infodemic.
Increasing global temperatures threaten gains in maternal and newborn health in Africa: A review of impacts and an adaptation framework
Authors: Chersich Matthew F. , Scorgie Fiona , Filippi Veronique , Luchters Stanley ,   Climate Change and Heat‐Health Study Group
Published: July 2022

AbstractAnatomical, physiologic, and socio‐cultural changes during pregnancy and childbirth increase vulnerability of women and newborns to high ambient temperatures. Extreme heat can overwhelm thermoregulatory mechanisms in pregnant women, especially during labor, cause dehydration and endocrine dysfunction, and compromise placental function. Clinical sequelae include hypertensive disorders, gestational diabetes, preterm birth, and stillbirth. High ambient temperatures increase rates of infections, and affect health worker performance and healthcare seeking. Rising temperatures with climate change and limited resources heighten concerns. We propose an adaptation framework containing four prongs. First, behavioral changes such as reducing workloads during pregnancy and using low‐cost water sprays. Second, health system interventions encompassing Early Warning Systems centered around existing community‐based outreach; heat‐health indicator tracking; water supplementation and monitoring for heat‐related conditions during labor. Building modifications, passive and active cooling systems, and nature‐based solutions can reduce temperatures in facilities. Lastly, structural interventions and climate financing are critical. The overall package of interventions, ideally selected following cost‐effectiveness and thermal modeling trade‐offs, needs to be co‐designed and co‐delivered with affected communities, and take advantage of existing maternal and child health platforms. Robust‐applied research will set the stage for programs across Africa that target pregnant women. Adequate research and climate financing are now urgent.
Effects of ridge planting on crop seedlings under saline water drip irrigation
Authors: Han Xiaoyu , Kang Yaohu , Wan Shuqin , Li Dan 
Published: July 2022

AbstractA field experiment was conducted in northwest China to study the effects of different irrigation water salinity levels on the emergence and growth of corn, sunflower, summer squash, and cowpea. Two tillage systems (flat and ridge planting) and five salinity levels (at 1.7, 4.0, 6.3, 8.6, and 10.9 dS/m) were tested. Compared with flat planting, the soil salinity within 30 cm horizontally from the drip tapes decreased by 15% in the ridge planting system. Ridge planting significantly improved the emergence and growth of crops, which was mainly manifested in higher emergence rates, reduced emergence time, and increased dry biomass, especially under high‐salinity conditions (electrical conductivity of irrigation water >4 dS/m). The electrolytic conductivity of the saturation extract threshold at which corn, sunflower, summer squash, and cowpea endured without reduced emergence rates was 5.8, 5.8, 4.8, and 4.0 dS/m, respectively. Above this threshold, the relative emergence rate decreased by 11%, 16%, 14%, and 20%, respectively. Our results indicate the agronomic benefits of ridge planting, and the soil environment was improved by ridge planting with saline water drip irrigation. In addition, we discuss the crop responses in terms of emergence rates and relative seedling dry biomass in relation to soil salinity. Suggestions for the secure and efficient use of saline water for irrigation in arid regions have been put forward.
Architecting rural smartness: A collaborative platform design for rural digital business ecosystem
Authors: Mukti Iqbal Yulizar , Firdausy Danniar Reza , Aldea Adina , Iacob Maria E. 
Published: July 2022

AbstractThe wide urban–rural economic gap, particularly in developing countries, has led to various problems. To lower the gap, the participation of rural communities in digital business ecosystems is being viewed as a promising approach. To this end, we use design science research methodology to present a reference architecture of a rural smartness platform that facilitates the emergence of a smarter business ecosystem. This ecosystem embodies the characteristics of rural smartness, which are empirically proven to have a strong positive impact on improving the rural economic climate. Evaluation by means of expert opinion, technical action research, and empirical research suggest that the proposed architecture effectively improves the rural economic climate and is feasible to be implemented in a real‐world setting. This paper contributes to the body of knowledge regarding the establishment of a digital business ecosystem for rural communities, particularly by proposing a solution resulting from a design science perspective that is backed by empirical evidence.
Comparison of the enhanced attachment and proliferation of the human mesenchymal stem cells on the biomimetic nanopatterned surfaces of zein, silk fibroin, and gelatin
Authors: Huang Xueying , Zeng Jie , Wang Yi 
Published: July 2022

AbstractNatural proteins have been reported to positively affect the attachment and proliferation of cells. For the first time, zein, a plant protein, was utilized to make patterned surface mimicking the extracellular matrix to assist the attachment and proliferation of stem cells. Zein would promote the attachment and proliferation of the stem cells more than 10 times of that of gelatin and silk fibroin, respectively, which are popular protein selections for the formation of the biomaterial scaffolds. The more the surface was covered by zein, the more the stem cell grown. It was revealed that the stem cells would grow and stretch in the direction of the patterns, and the stem cells preferred to grow in the grooves in the size of 8 μm, that was similar to the size of the stem cells, rather than the size larger or smaller than that of the cells, such as 50 and 2 μm. It was concluded that zein is a better choice than silk fibroin and gelatin with highly potential for the formation of patterned surface and structure as the biomaterial scaffolds for stem cell therapy.
Reduction of Mature B Cells and Immunoglobulins Results in Increased Trabecular Bone
Authors: Lagerquist Marie K. , Gupta Priti , Sehic Edina , Horkeby Karin L. , Scheffler Julia M. , Nordqvist Jauquline , Lawenius Lina , Islander Ulrika , Corciulo Carmen , Henning Petra , Carlsten Hans , Engdahl Cecilia 
Published: July 2022

ABSTRACTInflammation has a significant effect on bone remodeling and can result in bone loss via increased stimulation of osteoclasts. Activated immunoglobulins, especially autoantibodies, can increase osteoclastogenesis and are associated with pathological bone loss. Whether immunoglobulins and mature B lymphocytes are important for general bone architecture has not been completely determined. Here we demonstrate, using a transgenic mouse model, that reduction of mature B cells and immunoglobulins leads to increased trabecular bone mass compared to wild‐type (WT) littermate controls. This bone effect is associated with a decrease in the number of osteoclasts and reduced bone resorption, despite decreased expression of osteoprotegerin. We also demonstrate that the reduction of mature B cells and immunoglobulins do not prevent bone loss caused by estrogen deficiency or arthritis compared to WT littermate controls. In conclusion, the reduction of mature B cells and immunoglobulins results in disturbed regulation of trabecular bone turnover in healthy conditions but is dispensable for pathological bone loss. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
The hepatoprotective effects of taurine against oxidative stress induced by isotretinoin in rats
Authors: Taziki Shohreh , Gholamzadeh Faramarz , Hosseini Rozhin 
Published: July 2022

AbstractLiver disorders are one of the principal reasons for mortality in the world. Isotretinoin is a systemic retinoid that has been approved for therapy of acne vulgaris since 1982. This drug causes complications in the body. Evidence suggests that Isotretinoin might cause hepatotoxicity. Our research aimed to study the exact mechanism of hepatotoxicity induced by isotretinoin and the protective role of taurine in this toxicity. Biomarkers such as aspartate transaminase (AST) and alanine transaminase (ALT), superoxide dismutase, glutathione content (GSH), catalase, and malondialdehyde (MDA) were examined. Furthermore, pathological changes were evaluated. The results showed that oral administration of Isotretinoin induced hepatotoxicity as showed by elevation in ALT, AST, and MDA; also, it reduced intracellular GSH in rat liver tissue. Administration of taurine prevented the hepatotoxicity induced by isotretinoin in rats significantly.
Quercetin attenuates cyclophosphamide induced‐immunosuppressive indoleamine 2,3‐dioxygenase in the hippocampus and cerebral cortex of male Wister rats
Authors: Ebokaiwe Azubuike P. , Ushang Odobi R. , Ogunwa Tomisin H. , Kikiowo Babatomiwa , Olusanya Olasiende 
Published: July 2022

AbstractThis study investigated the protective effect of quercetin against cyclophosphamide‐induced immunosuppressive indoleamine 2,3‐dioxygenase (IDO) via the mechanism of oxidative‐inflammatory stress and behavioral indices. Cyclophosphamide (CYP) was administered to male Wister rats at a dose of 100 mg/kg with or without quercetin 50 mg/kg every other day for 7 days. Experimental techniques including western blotting, immunohistochemistry analysis, and inflammatory and oxidative stress marker assays were carried out. We also conducted behavioral analyses such as open field, tail suspension, and Y‐maze tests for cognitive assessment. The results indicated that quercetin attenuated oxidative‐inflammatory stress induced by CYP in the hippocampus and cerebral cortex of male Wister rats by augmenting the activities of antioxidant enzymes and suppressing lipid peroxidation as well as inflammatory mediators such as interleukin‐6 and interferon‐γ. Concomitantly, quercetin partially prevented the alteration in brain tissue histological architecture and mitigated the activities of IDO/tryptophan 2,3‐dioxygenase (TDO) and protein expression of IDO1. This was corroborated by the IDO‐quercetin model obtained in silico, revealing a favorable inhibitory interaction between quercetin and the enzyme. Finally, the results of behavioral tests suggested that quercetin significantly prevented the depressive‐like posture of the CYP‐treated rats. Our study for the first time revealed that quercetin ameliorates the effect of CYP‐instigated IDO/TDO activities in the cerebral cortex and hippocampus via restoration of antioxidant enzymes and preventing oxidative‐inflammatory stress.
Integration of soil washing and cork permeable reactive barriers for the remediation of soil contaminated with polycyclic aromatic hydrocarbons
Authors: Silva Karyn NO , Henrique João MM , Đolić Maja B , Martínez‐Huitle Carlos A , Dos Santos Elisama V , Moreira Francisca C , Vilar Vítor JP 
Published: July 2022

AbstractBACKGROUNDSoil washing is a well‐known technology for the remediation of soils polluted by organic contaminants, including polycyclic aromatic hydrocarbons (PAHs). This study aimed to go further by integrating soil washing and permeable reactive barriers (PRBs) made of cork granules to remove PAHs from the soil. While PAHs may be transferred from the soil to the washing solution in the soil washing step, the cork PRB may provide the removal of PAHs from the washing solution, ultimately leading to the reuse of this solution.RESULTSThe integrated approach was tested by means of packed bed column experiments in the absence and presence of cork PRBs. Two PAHs were under focus: fluorene (FLU) and phenanthrene (PHE). In soil with 0.5 mmol L−1 kgsoil−1 of FLU and PHE, the soil washing technique employing thermally treated cork granules and a solution of 70%/30% water/acetonitrile (v/v) flowing at 2.2 mL min−1 promoted the transfer of ~58% of PAHs from the soil to the washing solution, while the cork PRB retained ~98% of the PAHs from the washing solution. The acetonitrile content of the water/acetonitrile washing solutions contributed to the soil washing since it was responsible for PAH desorption and elution, however it was unfavorable for PAH sorption onto the cork as acetonitrile competed with PAHs for cork sorption sites.CONCLUSIONCork PRBs were able to retain PAHs from soil washing solutions and provide final solutions free of PAHs, demonstrating the viability of integrating solvent‐aided soil washing with cork PRBs. © 2022 Society of Chemical Industry (SCI).