bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders
Authors: Luo Jie , Niu Mingming , Li Ling , Kong Dehui , Jiang Yi , Shieh Annie , Cheng Lijun , Giase Gina , Grennan Kay , White Kevin , Chen Chao , Wang Sidney , Pinto Dalila , Wang Yue , Liu Chunyu , Peng Junmin , Wang Xusheng 
Published: May 2022

Abstract

Psychiatric disorders are highly heritable yet polygenetic, potentially involving hundreds of risk genes. Genome-wide association studies (GWAS) have identified hundreds of genomic susceptibility loci for psychiatric disorders, but how these loci contribute to the underlying psychopathology and etiology remains elusive. Here we generated a deep human brain proteome by quantifying 11,672 proteins across 288 subjects using 11-plex tandem mass tag (TMT) coupled with two-dimensional liquid chromatography-tandem mass spectrometry (LC/LC-MS/MS). We identified 788 cis-acting protein quantitative trait loci (cis-pQTLs) associated with 883 proteins at a genome-wide false discovery rate (FDR) < 5%. In contrast to expression at transcript level and complex diseases that are found to be mainly influenced by noncoding variants, we found protein expression level tends to be regulated by non-synonymous variants. We also provided evidence of 487 shared regulatory signals between gene expression (i.e., eQTL) and protein abundance (i.e., pQTLs). Mediation analysis revealed that for most (64%) of the colocalized genes, the expression level of their corresponding proteins are regulated by cis-pQTLs via gene transcription. Causality analysis by Mendelian Randomization (MR) revealed 4 cis-pQTLs and 19 cis-eQTLs causally controlling schizophrenia (SCZ) GWAS loci, respectively. We further integrated multiple omic data together with network analysis to prioritize candidate genes for SCZ GWAS loci. Collectively, our results underscore the potential of proteome-wide linkage analysis for mechanistic understanding of psychiatric disorders.
Heat shock protein 90α is a potential prognostic and predictive biomarker in hepatocellular carcinoma: a large-scale and multicenter study
Authors: Su Ke , Liu Yanlin , Wang Pan , He Kun , Wang Fei , Rao Mingyue , Li Xueting , Wen Lianbin , Song Yanqiong , Zhang Jianwen , Gu Tao , Xu Ke , Li Qi , Chen Jiali , Wu Zhenying , Li Han , Huang Weihong , Chen Lan , Tong Jian , Li Hongyan , Feng Xunjie , Chen Siyu , Yang Binbin , Jin Hongping , Yang Yue , Liu Hanlin , Yang Chao , Wu Min , Xiong Fangyu , Peng Keyi , Zhu Lechuan , Xu Yaoyang , Tang Xue , Tan Zunyuan , Luo Xiaotong , Zheng Hanyue , Zhang Yuxin , Guo Lu , Han Yunwei 
Published: May 2022

Abstract
BackgroundAlthough the diagnostic value of plasma heat shock protein 90α (HSP90α) in hepatocellular carcinoma (HCC) has been previously reported, the causal effect of plasma HSP90α levels on HCC prognosis remains largely unclear. To this extent, we sought to assess whether plasma HSP90α act as a prognostic factor for HCC patients.MethodsA total of 2150 HCC patients were included in this retrospective study between August 2016 and July 2021. Plasma HSP90α levels were tested within a week prior to treatment and their association with prognosis was assessed.ResultsAn optimal cut-off value of 143.5 for the HSP90α based on overall survival (OS) was determined using the X-tile software. HCC patients with HSP90α < 143.5 ng/ml (low HSP90α) had longer median OS (mOS) compared to those with HSP90α ≥ 143.5 ng/ml (high HSP90α) (37.0 vs. 9.0 months, P < 0.001), indicating that high HSP90α plasma level is an independent poor prognostic factor for OS in HCC patients. In our subgroup analysis, including supportive care group, surgery group, transarterial chemoembolization (TACE) group, adjuvant TACE group, immune checkpoint inhibitor (ICI) plus targeted therapy group, and TACE plus ICI group, the high HSP90α group demonstrated better OS compared to the low HSP90α group. Moreover, in the supportive care, TACE, ICI plus targeted therapy and TACE plus ICI groups, high HSP90α levels was also an independent poor prognostic factor for OS.Conclusions Our study confirmed that plasma HSP90α could be used as a prognostic biomarker for HCC.
Effect of Architecture on Natural Ventilation Enhancement; an Ancient Windmill in Sistan, Iran
Authors: Mohammadi Elham , Jarkeh Mohammadreza , Arbabi Vahid , Zolfaghari Alireza 
Published: May 2022

Abstract
Over centuries different elements have been developed in architectures for ensuring adequate natural ventilation in residential units. This study assesses the different components of an ancient windmill in Sistan, Iran, on the structure's indoor air quality (IAQ) enhancement. Several climatic scenarios have been defined by the wind analysis of Sistan meteorological data and analyzed by CFD. The site measurements confirm the accuracy of the simulation results. In the windmill, two deflectors facing the prevailing wind are the significant elements which, in addition to the directing wind toward the entrance, they could form vortices near the east and west openings leading to suction ventilation. Alteration of the wind speed and angle from 10 m/s to 15 m/s and 30° to 17° would increase the air change per hour (ACH) by 150% and 110%, respectively. Meanwhile, the ACHs were higher than the ASHRAE desired level (ACH > 0.35).
Two-photon absorption cross-section investigation of visible light photoinitiators under Q-switched Nd:YAG nanosecond pulse laser at 1064 nm
Authors: Romphosri Suwat , Oo Phyu Sin , Karanyasopon Pornpawee , Traiphhol Rakchart , Waritanant Tanant 
Published: May 2022

Abstract
Two-photon polymerization (TPP) technologies commonly rely on femtosecond lasers such as Ti:sapphire which limits their accessibility due to high costs and complexities. Recently, multiple reports showed TPP under near-infrared irradiation which enables the use of alternative light sources such as Neodymium-doped lasers known to be affordable and efficient for nanosecond and picosecond pulsed generation. 4,4′-bis(dimethylamino) benzophenone or Michler’s ketone (MK), one of the photoinitiators commonly used for photopolymerization under UV irradiation, also shows an absorption band in the visible region which allows for two-photon polymerization at the fundamental wavelength of Neodymium-doped lasers at 1064 nm. In this report, we investigated the two-photon absorption (TPA) of MK in contrast with Irgacure-784 and Indane-1,3-dione, reported to also be promising photoinitiators for the same TPP process. Among them, MK showed a large TPA cross-section measured via the nonlinear transmission method and Z-scan technique with Q-switched Nd:YAG nanosecond pulse laser at 1064 nm, demonstrating MK as a promising photoinitiator for the low-cost two-photon polymerization.
Latent neural population dynamics underlie normal and disrupted breathing
Authors: Ramirez Jan-Marino , Bush Nicholas 
Published: May 2022

Abstract
Breathing is a vital rhythmic motor behavior incessant from the first to our last breath. Increasingly refined anatomical, physiological, and genetic methods identified critical neuronal structures for breathing in a rostro-caudally aligned column of discrete functional nuclei with distinct neuron types that constitute the Ventral Respiratory Column (VRC). However, the concept of such compartmentalized organization must be reconciled with the considerable neuronal heterogeneity distributed along the entire VRC. Using Neuropixel probes we record simultaneously from hundreds of neurons across the entire VRC in anesthetized, but otherwise intact, freely breathing mice. Combined with optogenetic tagging techniques, and 3D histological reconstruction we create a functional, anatomic, and genetic map of over 13,000 neurons in the VRC with single-unit and millisecond resolution. By applying recent neural population analyses we uncover that a highly constrained rotational latent dynamical mode governs normal breathing. Our data reveal that the offset of inspiration forms an attractor that resets the respiratory rhythm, suggesting that the respiratory cycle begins not at the onset of an inspiration, but its cessation. These trajectories are sensitive to metabolic and pharmacological manipulations. Opioid administration alters the latent timing, while hypoxia-induced gasping results in a discrete reconfiguration from rotational to ballistic dynamics. These data provide a novel look at an old problem. They conceptualize the constitutive components of respiratory neural activity not as being composed of the average activity of homogenous genetic cell-classes or single nuclei, but of the underlying low dimensional neural activity patterns (neural modes) which may be distributed across cells of a given genotype and/or anatomical location.
Magnetized water irrigating influences the growth and quality characteristics of Capsicum annuum L. under greenhouse cultivation in Shouguang city
Authors: Liu Xiumei , Ma Fengyun , Kong Linggang , Guo Jianyao , Meng Shiyuan , Bi Sisheng , Wang Lu 
Published: May 2022

Abstract
Background: Magnetic techniques have been reported as a feasible technology to improve the plant growth environment and help to promote soil restoration. Hence, it we applied these techniques, aiming to explore the effect of the magnetic treatment of irrigation water on promoting soil microecological conditions and seedling growth and production. A field experiment was performed under the cultivation conditions of a solar greenhouse. The crop Capsicum annuum L. was cultured in season during 2017 and 2018. A magnetic device was used to treat water, and two irrigation treatments were carried out. The physicochemical properties in the soil and the characteristics of seedling growth and parameters of fruits in long hot green pepper were analyzed.Results: Magnetized water irrigation (MWI) had the potential to promote bacterial and enzyme activities through increases in alpha-diversity indexes, abundance and multiple species, whereas mineral nutrient contents were enhanced. MWI had positive effects on promoting the physical characteristics in soil, which reduced the pH and bulk density and increased the total porosity and moisture content. MWI promoted morphological characteristics in both leaves and fruits and increased the fresh weight per fruit. MWI improved mineral nutrient contents and fruit quality. Moreover, the results of a correlation analysis between mineral nutrients, alpha-diversity parameters and bacterial communities showed that the relative abundance value was more than 10%, revealing that the dominant bacterial group of Proteobacteria was the opposite of Firmicutes and Bacteroidetes, whereas the latter two groups were significantly negatively correlated with the total contents of nitrogen and phosphorus and the contents of nitrate and ammonium nitrogen and available phosphorus but positively correlated with pH.Conclusions: In conclusion, The above results showed that irrigation with magnetically treated water could have helpful influences on soil quality; additionally, the improved soil conditions could be beneficial for the formation of bacterial groups, crop growth and output.
Groundwater quality assessment using water quality indices and GIS technique with kriging interpolation in Maadher plain of Hodna, northern Algeria
Authors: Selmane Tahar , Dougha Mostefa , Djerbouai Salim , Djemiat Djamaleddine , Lemouari Nadjet 
Published: May 2022

Abstract
In a semi-arid region of Maadher, central Hodna (Algeria), groundwater is the main source for agricultural and domestic purposes. The quality of groundwater is strongly influenced by surrounding anthropogenic activities under the effect of climate change. The objective of this study was to assess the quality of groundwater and its suitability for use in irrigation and drinking using quality indices and to identify polluted wells using geographic information system (GIS) by the spatial interpolation method of Kriging. The results showed that all water samples contained high levels of calcium, chlorine and sulfate, as well as alarming concentrations of nitrate ions that exceed WHO standards. Piper's diagram indicated that the groundwater hydrochemical facies is a sulfate-chloride-nitrate-calcium combination (SO₄2−-Cl−-NO₃⁻- Ca2+ water type). According to the water quality indices, the classifications of WQIs are similar, the majority of samples are in the poor water category and just over 10% of all samples are in the very poor water category, and less than 10% of the samples represent the good to excellent quality category. Irrigation water indices indicate that all samples are acceptable. Water quality maps generated using ordinary Kriging method show that high concentrations of salinization parameters (Ca2+, Na+, Mg2+, SO₄2− and Cl−) were found north of the Maadher zone and decrease as we move south; except for bicarbonate and nitrate which were high in the center of the zone, near the Wadi Bousaada depression. The study revealed that groundwater quality has been affected by anthropogenic activities represented by excessive agricultural practices and inflows from Wadi Bousaada. The groundwater saturation index was calculated to know the origin of the mineralization and the chemical processes that occur in the aquifer.
Fuzzy adaptive fixed-time quantized consensus tracking control of power-chained nonlinear multi-agent systems with uncertainties: a singularity-dispelled approach
Authors: Zhou Chuhan , Wang Wenfei , Wang Ying 
Published: May 2022

Abstract
This paper studies the distributed singularity dispelled fixed-time quantized consensus tracking control for quite a large family of power-chained (powers are positive odd integers) nonlinear multi-agent systems in the presence of uncertainties. It is extremely challenging to achieve fixed-time consensus for such dynamics because conventional feedback linearization and backstepping method successfully developed for low-power systems fail to work, and some exponential terms typically arising from fixed-time stability are difficult to design due to the existence of high powers and strong couplings among distinct agents. The fixed-time consensus tracking is realized by incorporating adding-one-power-integrator methodology into our newly proposed more general fixed-time stability criterion which is available for approximation based dynamics. The singularity issue existing ubiquitously in fixed-time control is overcome by delicately introducing a switching singularity dispelled function. Moreover, a variable-separable lemma is utilized to extract the input quantization in a “linear-like” manner and fuzzy approximators are utilized to estimate the uncertainties in system. It is rigorously proved that the consensus tracking error eventually converges to a residual set in fixed time, while the boundedness of all closed-loop signals are guaranteed. Numerical and practical simulations further verify the effectiveness of proposed scheme.
Evaluation the effect of grape seed extract (GSE) on oral mucositis in patients with head and neck radiotherapy history
Authors: Eslami Hosein , Jamali Zahra , Babaei Hossein , Fakhrzadeh Vahid , Ahmadi Javad , Tavakoli Fatemeh 
Published: May 2022

Abstract
Introduction: Mucositis is one of the most important complication of radiotherapy.Some factors such as type of treatment and degree of patiens sensivity effect on mucositis occurance.This research was implemented to evaluate the effect of grape seed extract on radiation induced mucositis.Method and material: This research is a double blinded randomized clinical trial implemented on 78 patients undergoing head and neck radiotherapy in oncology and radiotherapy ward of Imam Reza hospital of Tabriz. The patients were randomly divided in two groups, intervention and control group. each group included 39 patients. Intervention group used 2% grape seed extract mouthwashes and control group used placebo mouthwashes. The mouthwashes were used 3 times a day for 2 weeks. In order to statistical analyze of collected data, spss 20 software was applied.Results: The results showed that according to Friedman test, on 10th and 14th days mucositis grade and incidence had a significant difference between intervention and control groups.Conclusion: The study findings indicated that grape seed extract mouthwash in preventing radiation induced mucositis was more effective than placebo. Thus this agent can be recommended as an appropriate medicine in order to eliminate oral mucositis symptoms.
A Novel Approach to the Classification of Human Emotion and Analysis of Complete Mental State Using Brain EEG Signals
Authors: Kimmatkar Nisha , Babu B. Vijaya 
Published: May 2022

Abstract
In the area of brain-computer interface, Intelligent emotion detection based on Electroencephalography brain signals is of great significance. Currently, deep learning algorithms like DNN, CNN, and SVM have significantly improved detection and prediction accuracy in many fields. However, deep learning and SVM have certain limitations in perceiving global dependence. In the present scenario, most of the deep learning models rely on pre-processing, extracting features, and network topology but still are not sufficient to provide satisfactory accuracy for the small and noisy database. Overlapping in target classes and boundaries causes low performance of SVM no matter the dataset is highly dimensional with fewer samples. In this research study, the focus of the novel approach is on developing a classification strategy for working on more emotion types. A “Mean of Mean “algorithm is proposed to completely analyze mental state by considering all the features in the features set. Emotion is first classified into one of the quadrants from four quadrants of emotion by comparing with the referential mean and then depending on the intensity of arousal the emotion is further classified into 12 subtypes by using the MIN Max range. The proposed algorithm performed better compared to other algorithms and provide a wide range of emotion types. When compared to current research of multi-class emotion identification, the experimental findings demonstrated that the suggested technique is extremely competitive. The average accuracy rate was above 90%, and it provided a comprehensive assessment of the mental condition. On the emotional spectrum, a person's emotional state is assessed.
Does the Financial and Educational Status of the Patients Play a Role in Tooth Extraction?
Authors: Lima Fernanda Brasil Daura Jorge Boos , Costa Samuel Macedo , Ribeiro Bruna Campos , Vasconcelos Luana Soares , Frota Rodrigo Baeta da , Mota Barbara Gabrielle Bomfim da , Nunes Daniel Belo , Cruz Caio Diniz Da , Lima-Junior Sergio Monteiro 
Published: May 2022

Abstract
BackgroundsThe purpose of this study was to establish the relationship between educational status, family income, social inequality, and the Human Development Index (HDI) with the need for tooth extraction.MethodsThe authors conducted a 3,964 patients retrospective cohort, from 2007 to 2017, assessing gender, age, hometown, family income, general health data, educational level, extracted teeth, and cause of the extraction.ResultsFemales were predominant in a 1.5:1 ratio. The average number of removed teeth was 2.27 per patient. Third molar extraction was correlated with wealthier patients (p = .01), while poorer patients opted for the removal of other functional teeth. Neither social inequality nor human development promoted a correlation between which teeth were removed. Uneducated and poorly educated were related to the removal of other teeth, molars, and anterior teeth, rather than third molars (p = .032). Educated ones, with a college education and high school, preferably remove their third molar, without any other loss of permanent teeth (p = .006).ConclusionWealthy and educated patients are aware of oral health promotion programs, and usually seek elective treatment, especially third molars extractions, while the poor and uneducated are demanding treatment for functional teeth removal, worsening chewing, and aesthetics.
Influence of marine vertebrates on organic matter and trace element levels in Antarctic soils
Authors: Souza-Kasprzyk Juliana , Paiva Thais Castro , Convey Peter , Cunha Larissa Schmauder Teixeira , Soares Tuany Alves , Zawierucha Krzysztof , Costa Erli Schneider , Niedzielski Przemyslaw , Torres João Paulo Machado 
Published: May 2022

Abstract
The presence of marine vertebrates in reproductive colonies contributes to the input of organic matter into the local environment and it is believed that trace elements are subsequently remobilized from the excreta of these animals. In this study, we investigate the influence of marine vertebrates on trace elements levels (As, Cd, Co, Cu, Fe, Li, Lu, Mg, Mn, Ni, Pb, Sb, Sc, Se, Sm, Sn, Sr, Tb, U and Zn) and soil organic matter (SOM) content from five locations with and without marine vertebrate influence in Admiralty Bay, King George Island, South Shetland Islands. Soils were acid digested using microwave, elements were quantified using inductively coupled plasma mass spectrometry and SOM was calculated by loss-on-ignition. The non-influenced and vertebrate-influenced soils had similar concentrations of most of trace elements assessed, however we observed a significant increase in SOM that was positively correlated with the concentrations of As, Cd, Se, Sr and Zn. Although marine vertebrates do not appear to significantly influence trace element concentrations in the soils examined here, this conclusion is based on a limited overall sample size and there is evident input of organic matter linked with increased concentrations of elements correlated with SOM, indicating a possible ornithogenic influence. Contrasting our results with other studies, we conclude that soil elemental levels are an interplay between local geology, vertebrate diet and colony size. Further studies with increased sample size are required to obtain a better understanding of marine vertebrate influence on trace element levels in Antarctic soils.
Bond durability of a two-step adhesive with a universal-adhesive-derived primer in different etching modes under different degradation conditions
Authors: Takamizawa Toshiki , Hirokane Eizo , Sai keiichi , Ishii Ryo , Aoki Ryota , Barkmeier Wayne W , Latta Mark A , Miyazaki Masashi 
Published: May 2022

Abstract
Objectives
This study investigated the enamel and dentin bond durability of a two-step adhesive system, using a universal adhesive-derived primer (G2-Bond Universal [GU]), and compared it with the two conventional, two-step, self-etch adhesive systems (Clearfil SE Bond 2 [CS] and OptiBond XTR [OX]) under thermal cycling (TC) and long-term water storage (WS).
Materials and Methods
The shear bond strengths to bovine enamel and dentin were determined using the etch-and-rinse and self-etch modes. Twelve specimens per test group were prepared and further divided into the following subgroups: 1) subjected to TC, 2) long-term WS, and 3) WS for 24 h (baseline). The cured adhesive layers’ water contact angle and surface free energy were measured.
Results
Among the specimens in the baseline subgroups, the GU’s enamel and dentin bond performances were equivalent to those of CS, regardless of the etching mode. Although GU’s enamel bond durability was similar to that of CS, its dentin bond durability was superior to those of the other adhesive systems in both etching modes. GU’s cured adhesive layer was more hydrophobic than those of the other adhesive systems.
Conclusion
The enamel and dentin bond durability of GU was superior to those of CS and OX in different etching modes and under different degradation conditions.
Clinical Relevance
The latest two-step adhesive system, which utilizes universal adhesives' benefits in its primer, might offer durable clinical bonding performances and can be widely used in a clinical setting.