bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exome Sequencing Expands the Genetic Diagnostic Spectrum for Pediatric Hearing Loss
Authors: Perry Julia , Redfield Shelby , Oza Andrea , Rouse Stephanie , Stewart Candace , Khela Harmon , Srinivasan Tarika , Albano Victoria , Shearer Eliot , Kenna Margaret 
Published: December 2022

ObjectivesGenetic testing is the standard‐of‐care for diagnostic evaluation of bilateral, symmetric, sensorineural hearing loss (HL). We sought to determine the efficacy of a comprehensive genetic testing method, exome sequencing (ES), in a heterogeneous pediatric patient population with bilateral symmetric, bilateral asymmetric, and unilateral HL.MethodsTrio‐based ES was performed for pediatric patients with confirmed HL including those with symmetric, asymmetric, and unilateral HL.ResultsES was completed for 218 probands. A genetic cause was identified for 31.2% of probands (n = 68). The diagnostic rate was 40.7% for bilateral HL, 23.1% for asymmetric HL, and 18.3% for unilateral HL, with syndromic diagnoses made in 20.8%, 33.3%, and 54.5% of cases in each group, respectively. Secondary or incidental findings were identified in 10 families (5.52%).ConclusionES is an effective method for genetic diagnosis for HL including phenotypically diverse patients and allows the identification of secondary findings, discovery of deafness‐causing genes, and the potential for efficient data re‐analysis.Level of Evidence4 Laryngoscope, 133:2417–2424, 2023
Comparison of two conchal formers for nonsurgical correction on Conchal Crus
Authors: Zou Qijuan , Zhao Shouqin , Wang Danni , Chen Peiwei , Yang Lin , Gao Mengdie , Liu Yujie , Zhao Chunli , Li Sijia , Yang Jinsong 
Published: December 2022

AbstractObjectivesConchal Crus is a kind of congenital auricular deformation which is often overlooked. Few studies reported a large number of cases. We compared the efficacy of EarWell and self‐made conchal formers on Conchal Crus to summarize our experience of correction and to find out the influencing factors.MethodsTwo groups of Conchal Crus babies underwent conchal correction with the EarWell and self‐made conchal formers respectively. The combined auricular deformities in these babies were corrected with EarWell Infant Ear Correction System. Conchal Crus deformity was classified as severe and mild. Auricular and conchal morphologic outcomes were graded as excellent, good, and poor.ResultsThe auricular morphologic results were comparable between the two groups. There was no significant difference in the effective (excellent plus good) rate between the two groups, but the excellent rate for conchal results in the Self‐made group was significantly higher than that in the EarWell group. The former incidence of pressure ulcers was significantly lower than the latter. Multinomial regression analysis showed that the more severe conchal deformity was, the less likely the conchal shape tended to be improved.ConclusionBoth conchal formers could correct Conchal Crus effectively. The self‐made conchal former could make more excellent conchal fossae and lead to less pressure ulcers at the Conchal Crus. The degree of Conchal Crus deformity was an important influencing factor in the conchal correction outcome.Level of evidence4
Kinetics of nitrous oxide production from ammonia oxidation in the Eastern Tropical North Pacific
Authors: Frey Claudia , Sun Xin , Szemberski Laura , Casciotti Karen L. , Garcia‐Robledo Emilio , Jayakumar Amal , Kelly Colette L. , Lehmann Moritz F. , Ward Bess B. 
Published: December 2022

AbstractMarine oxygen‐deficient zones represent a natural source of nitrous oxide (N2O), a potent greenhouse gas and ozone‐depleting agent. To investigate controls on N2O production, the responses of ammonia oxidation (AO) to nitrite () and N2O with respect to oxygen (O2), ammonium () and concentrations were evaluated using tracer incubations in the Eastern Tropical North Pacific. Within the oxycline, additions of and O2stimulated N2O production according to Michaelis–Menten kinetics, indicating that both substrates were limiting, and that N2O production, even if the exact mechanisms remain uncertain, is mediated by predictable kinetics. Low half‐saturation constants for (12–28 nM) and O2(460 ± 130 nM) during N2O production indicate that AO communities are well adapted to low concentrations of both substrates. Hybrid N2O formation (i.e., from one and one unlabeled nitrogen (N) source, e.g., , NO) accounted for ~ 90% of the N2O production from and was robust across the different O2, , and conditions. Lack of response to variable substrate concentrations implies that the unlabeled N source was not limiting for N2O production. Although both O2and were key modulators of N2O production rates, N2O yield (N2O produced per produced) seemed to be controlled solely by O2. The N2O yield increased when O2concentrations dropped below the half‐saturation concentration for AO to (< 1.4 μM), the range where production decreased faster than N2O production. Our study shows that O2control on N2O yield from AO is robust across stations and depths.
Merits matter: A new perspective on multifaceted pride and its effects on conspicuous consumption
Authors: Kwon Yongju , Park Kiwan 
Published: December 2022

AbstractIn the present research, we propose a new perspective on multifaceted pride based on merits of achievements. We define merited pride as the feeling of accomplishment resulting from achievements one believes primarily resulted from internal factors, and unmerited pride as a similar feeling resulting from achievements one believes primarily resulted from external factors. We examine how these newly proposed facets of pride differentially affect conspicuous consumption. We propose, and three studies confirm, that individuals with unmerited (vs. merited) pride show a higher propensity for conspicuous consumption. Furthermore, we identify the need for signaling status as a psychological mechanism underlying the effect of pride on conspicuous consumption. Finally, we find that the proposed effect is more pronounced when the achievements are framed as nonfailure rather than as success. The current research contributes to the literature by supporting our new perspective on multifaceted pride and demonstrating the link between the newly proposed facets of pride and conspicuous consumption. Our findings have practical implications with regard to the design of advertising messages for luxury products and consumer education programs for people who are addicted to conspicuous consumption.
Climatological characteristics of nocturnal eastward‐propagating diurnal precipitation peak over South India during summer monsoon: Role of monsoon low‐level circulation and gravity waves
Authors: Konduru Rakesh Teja , Matsumoto Jun , Yokoi Satoru , Mori Shuichi 
Published: December 2022

AbstractThis study explores the climatological diurnal cycle of precipitation during the summer monsoon season over southeast India using the Tropical Rainfall Measuring Mission (TRMM) 3G68 precipitation product from 2000 to 2014. The primary area of focus is the leeward side of the Western Ghats. We found that the climatological diurnal cycle over this area exhibits a bimodal peak with an afternoon/evening peak near the eastern slopes of the Western Ghats and a nocturnal peak near the southeast coast. This nocturnal peak near the southeast coast propagated offshore in the eastward direction with a phase speed of 18–20 m s−1 and attained an offshore peak in the late night/early morning. The afternoon diurnal peak is associated with daytime convection and propagates eastward over southeast India. The nocturnal peak is due to the convergence of intensified monsoon low‐level westerly winds along the land–sea boundary over the leeward side and supports the nocturnal diurnal peak to cross the coast at late night. The eastward‐propagating gravity waves support further eastward offshore propagation of nocturnal diurnal precipitation patterns. Altogether, the leeward‐side climatological diurnal peaks and diurnal variability in southeast India are controlled by complex precipitation types and their formation mechanisms due to monsoon low‐level westerly winds and gravity waves.
Antidepressant‐like effects of geniposide in chronic unpredictable mild stress‐induced mice by regulating the circ_0008405/miR‐25‐3p/Gata2 and Oip5os1/miR‐25‐3p/Gata2 networks
Authors: Zhao Yu , Zhang Qian , Yan Yuzhu , Wang Xinbo , Shao Yin , Mei Cheng , Zou Tianyu 
Published: December 2022

AbstractEvidence exists suggesting the anti‐depressive activities of geniposide (GP), a major compound in Gardenia jasminoides Ellis. Accordingly, the present study attempts to explore the anti‐depressive mechanism of GP in chronic unpredictable mild stress (CUMS)‐induced depression‐like behaviors of mice. CUMS‐induced mice were given GP daily and subjected to behavioral tests to observe the effect of GP on the depression‐like behaviors. It was noted that GP administration reduced depression‐like behaviors in CUMS mice. Transcriptome sequencing was conducted in three control and three CUMS mice. Differentially expressed circRNAs, lncRNAs and mRNAs were then screened by bioinformatics analyses. Intersection analysis of the transcriptome sequencing results with the bioinformatics analysis results was followed to identify the candidate targets. We found that Gata2 alleviated depression‐like behaviors via the metabolism‐ and synapse‐related pathways. Gata2 was a target of miR‐25‐3p, which had binding sites to circ_0008405 and Oip5os1. circ_0008405 and Oip5os1 competitively bound to miR‐25‐3p to release the expression of Gata2. GP administration ameliorated depression‐like behaviors in CUMS mice through regulation of the circ_0008405/miR‐25‐3p/Gata2 and Oip5os1/miR‐25‐3p/Gata2 crosstalk networks. Taken together, GP may exert a potential antidepressant‐like effect on CUMS mice, which is ascribed to regulation of the circ_0008405/miR‐25‐3p/Gata2 and Oip5os1/miR‐25‐3p/Gata2 crosstalk networks.
City reputation and the role of sustainability in cities
Authors: Pérez‐Cornejo Clara , Rodríguez‐Gutiérrez Pablo , de Quevedo‐Puente Esther 
Published: December 2022

AbstractCity reputation is a valuable intangible asset that boosts the attractiveness of a city in terms of resources, events, tourism, or as a place of residence. Since city sustainability is understood as the framework of a city's economic activities conducted within the carrying capacity of the local environment to the benefit of the local population, it may help to satisfy city stakeholders' expectations over time; in other words, to enhance city reputation. Our results from Tobit analyses, based on an international sample of 62 cities between 2015 and 2018, confirm that city sustainability is a determinant of city reputation. Specifically, this study shows that the level of environmental, social, and economic sustainability affects positively city reputation. Our results are of interest to local authorities, as they indicate the relevance of efforts to consolidate city sustainability in order to build a good city reputation.
Antiviral Effect of Saffron Compounds on the GP120 of HIV‐1: an In Silico Study
Authors: Sabzian‐Molaei Fatemeh , Hosseini Seyedrafi , Bolhassani Azam , Eskandari Vahid , Norouzi Saeed , Hadi Amin 
Published: December 2022

AbstractSince most anti‐HIV‐1 drugs must penetrate host cells to prevent viral replication, developing viral inhibitors as drugs is essential because they inactivate viruses before binding to host cells. gp120 HIV‐1 surface glycoprotein, which has a role in the first stages of HIV‐1 infection and entrance of the virus to the cell, is one of the proper molecules for targeted therapy. The phenylalanine‐43 cavity located protectively between the inner and outer domains of gp120 of several virus variants has been an attractive medical target for its interaction with CD4. Contrary to industrial drugs, saffron‘s bioactivity has recently been noticed due to its bio‐accessibility and bioavailability, low toxicity, and ease of production. Due to its carotenoid content, this study examined, for the first time, the main components of saffron (Crocin, Picrocrocin, Safranal and Crocetin) for their ability to inhibit viral‐cellular membrane fusion and inactivate cell‐free HIV‐1.The dockings were performed using Autodock Vina Software to study the interactions between the saffron compounds mentioned above with gp120 and CD4 separately. Hence, the dockings were done using Autodock Vina software. The results showed that Crocin and Picrocrocin compounds attach to the protected Phe43 Cavity and Asp368, Trp427, and Ile371 (binding site) of gp120. To confirm the stability, the best complexes of docking were studied using molecular dynamic simulation (via Gromacs 2020.2). It was observed that Crocin keeps its attachment for 100 ns of the simulation, but Picrocrocin detaches. In the end, the binding affinity of Crocin and gp120 was calculated in the 100 snapshots of the last 10 ns of simulations using PRODIGY, which was −10.3 kcal/mol. Finally, Crocin was suggested as a treatment for AIDS. Based on our atomic‐level studies, we have determined that Crocin can stably bind to gp120 but not to human CD4+ T cells in the absence of HIV‐1.
Structure and Electronic Properties of Metalloboranes with General Formula Cp*3(μ‐H)M3B8H8 (M=Cr, Mo and W): The Effect of the Size of the Metal
Authors: Treto‐Suárez Manuel A. , Zarate Ximena , Schott Eduardo 
Published: December 2022

AbstractA family of Metalloborane of general formula Cp*3(μ‐H)M3B8H8 changing the metals M by Cr, Mo, and W, were theoretically studied via Density Functional Theory (DFT) incorporating the relativistic scalar (Scal) and spin‐orbit (SO) corrections. All the calculations agree with the experimental reports of the compound Cp*3(μ‐H)W3B8H8 and allowed us to describe the molecular and electronic structures of this family of Metalloborane. The electronic properties were modeled using reactivity indexes, Nucleus Independent Chemical Shift (NICS) indexes, Natural Bond Orbital (NBO), and other methods showing that the metallic core is aromatic. The spectroscopic properties were also studied via Time‐Dependent Density Functional Theory (TD‐DFT) showing a variation in the UV‐Vis spectra as the metallic atoms were changed. The most intense transitions are centered mainly over the metalloboranes cage with a decrease of the wavelengths as the metallic core gets bigger due to the increase of the HOMO‐LUMO gap. The Cp*‐Metalloborane core and the H‐Metalloborane core interactions were studied via the Morokuma‐Ziegler decomposition scheme, showing that the electrostatic interaction plays the most important role in the stabilization energy of the Cp*‐Metalloborane core. All our results suggest that the compound a (Cp*3(μ‐H)Cr3B8H8) and b (Cp*3(μ‐H)Mo3B8H8) will display similar properties to compound c (Cp*3(μ‐H)W3B8H8) and all of them are expected to have interesting properties.
Metal‐Based Nanozymes with Multienzyme‐Like Activities as Therapeutic Candidates: Applications, Mechanisms, and Optimization Strategy
Authors: Li Dan , Dai Danni , Xiong Gege , Lan Shuquan , Zhang Chao 
Published: December 2022

AbstractMost nanozymes in development for medical applications only exhibit single‐enzyme‐like activity, and are thus limited by insufficient catalytic activity and dysfunctionality in complex pathological microenvironments. To overcome the impediments of limited substrate availabilities and concentrations, some metal‐based nanozymes may mimic two or more activities of natural enzymes to catalyze cascade reactions or to catalyze multiple substrates simultaneously, thereby amplifying catalysis. Metal‐based nanozymes with multienzyme‐like activities (MNMs) may adapt to dissimilar catalytic conditions to exert different enzyme‐like effects. These multienzyme‐like activities can synergize to realize “self‐provision of the substrate,” in which upstream catalysts produce substrates for downstream catalytic reactions to overcome the limitation of insufficient substrates in the microenvironment. Consequently, MNMs exert more potent antitumor, antibacterial, and anti‐inflammatory effects in preclinical models. This review summarizes the cellular effects and underlying mechanisms of MNMs. Their potential medical utility and optimization strategy from the perspective of clinical requirements are also discussed, with the aim to provide a theoretical reference for the design, development, and therapeutic application of their catalytic effects.
Ligands in Lead Halide Perovskite Nanocrystals: From Synthesis to Optoelectronic Applications
Authors: Sun Wenda , Yun Rui , Liu Yuling , Zhang Xiaodan , Yuan Mingjian , Zhang Libing , Li Xiyan 
Published: December 2022

AbstractLigands are indispensable for perovskite nanocrystals (NCs) throughout the whole lifetime, as they not only play key roles in the controllable synthesis of NCs with different sizes and shapes, but also act as capping shell that affects optical properties and electrical coupling of NCs. Establishing a systematic understanding of the relationship between ligands and perovskite NCs is significant to enable many potential applications of NCs. This review mainly focuses on the influence of ligands on perovskite NCs. First of all, the ligands‐dominated size and shape control of NCs is discussed. Whereafter, the surface defects of NCs and the bonding between ligands and perovskite NCs are classified, and corresponding post‐treatment of surface defects via ligands is also summarized. Furthermore, advances in engineering the ligands towards the high performance of optoelectronic devices based on perovskite NCs, including photodetector, solar cell, light emitting diode (LED), and laser, and finally to potential challenges are also discussed.
Seismic analysis and connection optimization of the side column on modular prefabricated four‐sided connected composite shear wall
Authors: Ou Tong , Mei Can , Mao Jihua , Wang Dayang 
Published: December 2022

SummaryA modular prefabricated four‐side connected composite (MPFC) shear wall that consists of a composite shear wall modular (CSWM) and steel frame boundary elements is proposed. First, the finite element model (FEM) of the MPFC shear wall, which considers a plastic‐damage constitutive model of both concrete and steel materials, is established based on the finite‐element software ABAQUS. Second, the FEM accuracy of the MPFC shear wall is verified by the experimental results of a modular prefabricated two‐sided connected buckling‐restrained (MTB) steel plate shear wall. Third, the seismic performance of the MPFC shear wall is investigated based on the verified FEM. The connection between the CSWM and side column is optimized. Finally, the initial stiffness calculation formula of the MPFC shear wall that considers the impact of that the thickness ratio between the connection steel plate (CSP) and inner steel plate (ISP) is deduced. The results show that the peak bearing capacity, initial stiffness, total energy, and total strain energy of the MPFC shear wall increased by 42.47%, 44.81%, 113.24%, and 58.97%, respectively, compared with those of the MTB steel plate shear wall. The compressive corner damage of the reinforcement concrete faceplate (RCF) of the MPFC shear wall with a side column and CSWM is connected by a middle steel plate is effectively improved. Compared with those of the MPFC shear wall in which the side column and CSWM are connected by bolts, the shearing force, axial force, and bending moment of the side column of the MPFC shear wall in which the side column and CSWM are connected by the middle steel plate are notably decreased by 25.32%, 26.08%, and 39.51%, respectively. The FEM results are compared with the formula calculation results to establish its accuracy in calculating the initial stiffness of the MPFC shear wall.
The influencing factors of infectious complications after percutaneous nephrolithotomy: a systematic review and meta-analysis
Authors: Zhou Guiming , Zhou Yuan , Chen Rui , Wang Daoqi , Zhou Shumin , Zhong Jiao , Zhao Yuan , Wan Chuanping , Yang Bin , Xu Jinming , Geng Erkang , Li Guoxiong , Huang Yunfeng , Liu Haoran , Liu Jianhe 
Published: December 2022

AbstractInfection is the most common complications of percutaneous nephrolithotomy (PCNL) in treating urinary calculi. However, the risk factors for developing infectious complications after surgery have not been clarified, and the predictive value of some factors is controversial. This study aimed to assess the risk factors for postoperative infectious complications of PCNL. We performed a systematic search of PubMed, Web of Science, Cochrane Library, and EMBASE to obtain studies reporting risk factors for postoperative infection complications after PCNL. In this review, demographic factors, laboratory test factors, and perioperative factors were evaluated. The odds ratio (OR) or mean difference (MD) with a 95% confidence interval (CI) was calculated to assess the risk factors. A total of 18 studies were included, with a total of 7161 study patients with a mean age of 46.4 to 55.5 years and an incidence of infectious complications after PCNL ranging from 2.4% to 40.4%. Twelve factors were identified as independent risk factors for post-PCNL infection complications (P < 0.05), female (OR = 1.60, 95% CI 1.23–2.07), positive urine culture (UC) (OR = 3.16, 95% CI 2.11–4.74), positive renal pelvis urine culture (RPUC) (OR = 5.81, 95% CI 1.75–19.32), positive stone culture (SC) (OR = 5.11, 95% CI 1.46–17.89), positive urine leukocyte (OR = 3.61, 95% CI 2.45–5.34), infected stones (OR = 7.00, 95% CI 1.27–38.55), elevated blood leukocyte (MD = 0.71, 95% CI 0.31–1.10), elevated neutrophil-to-lymphocyte ratio (NLR) (MD = 0.55, 95% CI 0.43–0.66), preoperative stenting (OR = 1.55, 95% CI 1.10–2.20), multiple puncture access (OR = 2.58, 95% CI 1.75–3.82), prolonged operative time (MD = 10 20, 95% CI 4.80–15.60), and postoperative residual stone (OR = 1.56, 95% CI 1.24–1.98). Female, UC positivity, RPUC positivity, SC positivity, urine leukocyte positivity, infected stones, elevated peripheral blood leukocytes, elevated NLR, preoperative stent implantation, multiple puncture channels, prolonged operation time, and postoperative residual stones were identified as independent risk factors for infection complications after PCNL.