bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of recurrence in patients without non-inducibility of ventricular tachycardia at the end of ablation
Authors: Nakasone Kazutaka , Fukuzawa Koji , Kiuchi Kunihiko , Takami Mitsuru , Sakai Jun , Nakamura Toshihiro , Yatomi Atsusuke , Sonoda Yusuke , Takahara Hiroyuki , Yamamoto Kyoko , Suzuki Yuya , Tani Kenichi , Iwai Hidehiro , Nakanishi Yusuke , Hirata Ken-ichi 
Published: May 2022

Abstract
Background: Ventricular tachycardia (VT) non-inducibility at the end of ablation is associated with a less likely VT recurrence. However, it is not clear whether we should use VT non-inducibility as a routine end point of VT ablation. The aim of this study was to evaluate VT recurrence in patients in whom VT non-inducibility was not achieved at the end of the RF ablation and the factors attributing to the VT recurrence.Methods: We analyzed 62 patients in whom VT non-inducibility was not achieved at the end of the RF ablation were studied.Results: Over 2 years, 22 (35%) of the cases had VT recurrences. A multivariate analysis showed that an LVEF≥35% (HR:0.19; 95% CI:0.06- 0.49; P<0.01) and partial success as an acute ablation efficacy (HR:0.23; 95% CI:0.04- 0.81; P=0.02) were independent predictors of fewer VT recurrences. RF ablation was associated with a 91.1% reduction in VT episodes.Conclusion: Even if VT non-inducibility was not achieved, patients with an LVEF≥35% or in whom partial success could be achieved might be prevented from having VT recurrences. The validity of the VT non-inducibility of any VT should be evaluated considering each patient’s background and the results of the procedure.
Clinical and Radiological findings with long-term Conservative Therapy in lumbar and Cervical Disc Prolapse
Authors: ELDANASORY OMAR 
Published: May 2022

Abstract
Objectives: A retrospective analysis study of 40 patients, with cervical, and/or lumbar disc prolapse, to evaluate the effectiveness of long-term conservative treatment. Method: The study involved 40 patients with acute, or chronic onset of cervical or lumbar radiculopathy, due to disc prolapse between 2015 and 2019. All patients had a standard neurological and clinical assessment, with follow-up Magnetic Resonance Imaging (MRI) for a period ranging from 2 to 3 years. The Associations between clinical findings during the physical examination and follow-up MRI imaging findings were compared and discussed. Their age ranges from 25 years old up to 50 years old (13 women (32.5%) and 27 men (67.5%)). All patients were refusing surgery because of the surgical drew back occurring to their family members for the same surgery, due to medical problems preventing surgery, or had improvement with long- term conservative therapy. The protocol of medical treatment and physiotherapy were the same for all patients.Results: Long-term conservative treatment for cervical and lumbar disc prolapses could be superior and better than surgical treatment in acute disc prolapse without any neurological deterioration. The surgical treatment of the cervical and lumbar disc prolapses in young patients is has not been considered the gold slandered option of treatment because of the postoperative complications especially recurrence disc and the failed back surgery syndrome.Conclusion: The conservative treatment of cervical and/or lumbar disc prolapses of all selected patients who received the same protocol was effective for long-term therapy. The follow-up MRI spine was also very effective and show spontaneous regression of the disc materials for all patients. Therefore, conservative management of disc prolapses could be superior and better than surgical management especially, in acute stages.
A hybrid tool wear prediction model based on JDA
Authors: Huang Hua , Yao Jiajing , Zhi Xiaobo , Pang Qianzhi , Xue Wenhu 
Published: May 2022

Abstract

Tool wear monitoring plays a vital role in improving product quality and reducing production costs. Aiming at the problems of low prediction accuracy and poor generalization caused by the difference in tool wear data distribution and the fixation of single global model parameters, a hybrid prediction modeling method for tool wear based on joint distribution adaptation (JDA) is proposed. Firstly, JDA is exploited to adapt the data features under different data distributions. Then, the adapted data features are identified by the KNN classifier. Finally, according to the tool state classification results, different regression prediction models are assigned to different wear stages to complete the whole tool wear prediction task. The results of milling experiments show that the maximum prediction accuracy of this method can reach 91.15%, and it has good recognition accuracy and generalization performance. Through the analysis of the tool wear hybrid prediction modeling method, the research can improve the prediction accuracy and generalization performance of the model and realize tool on-line monitoring. The research results can provide solutions and a theoretical basis for the application of tool wear monitoring technology in practical production.
Inhaled corticosteroids do not affect the antibody titer against the SARS-CoV-2 spike protein in BNT162b2 mRNA vaccinated patients
Authors: Nakajima Takeo , Nagano Tatsuya , Miyata Yoshiharu , Murakami Shoko , Mitsuyuki Satoshi , Funakoshi Yohei , Yakushijin Kimikazu , Horimoto Hitoshi , Nishimura Yoshihiro 
Published: May 2022

Abstract
Objectives: Oral corticosteroids reduce the antibody titer of the BNT162b2 mRNA vaccine against SARS-CoV-2. To date, the effect of inhaled corticosteroids on antibody titers is unknown.Study Design: The design of this study is retrospective study.Methods: We analyzed the relationship between the clinical features and total antibody titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein in 320 subjects who had never been infected with Coronavirus disease 2019 (COVID-19) and were vaccinated the second time with the BNT162b2 mRNA vaccine between October 1 to December 28, 2021.Results: Of the 320 subjects, 205 were treated with inhaled corticosteroids. The median antibody titer of patients treated with inhaled corticosteroids was 573 U/mL, which was significantly higher than that of patients treated without inhaled corticosteroids (451 U/mL, P=0.00155). The median antibody titers of smokers, men, and patients aged 65 years and over, were 315.5 U/mL, 385 U/mL, and 425.5 U/mL, respectively. These results are significantly lower than those of patients who never smoked, women, and patients aged less than 64 years (582 U/mL [P<0.001], 682.5 U/mL [P<0.001], and 717 U/mL [P<0.001], respectively). The multivariate analysis revealed that smoking history, females, and age were independent antibody titer-reducing factors (P=0,0458, <0.001, and P <0.001, respectively). Conclusions: The use of inhaled corticosteroids did not reduce the antibody titer against SARS-CoV-2 spike protein. Clinicians should continue treatment with inhaled corticosteroids if indicated.
Safety and outcomes of combined immune checkpoint inhibitor and radiation therapy for patients with melanoma brain metastases
Authors: Desagneaux Andréa , Charles Julie , Kastler Adrian , Dols Anne -Marie , Leccia Marie-Thérèse , Elhalawani Hesham , Aizer Ayal , Flandin Isabelle , Verry Camille 
Published: May 2022

Abstract
INTRODUCTION:
In spite of the promising results of systemic treatment in melanoma, the development of brain metastases remains a common issue, often prompting use of Radiation Therapy (RT). The purpose of this study is to assess the safety and outcomes of Immune Checkpoint Inhibitor (ICI) and brain RT with a focus on timing of both treatments.
METHODS
This retrospective study included all consecutive patients treated for a brain metastatic melanoma with an ICI (anti – CTLA4 or anti – PD1 or both) and brain RT from December 1, 2010 and April 30, 2018. The concurrent group was defined by an ICI performed within 4 weeks before or after RT. Primary endpoint was neurological adverse events graded with Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.
RESULTS
Fifty - three consecutive patients were included. A total of 81 RT courses were performed: 23 with whole brain radiotherapy (WBRT) and 58 with stereotactic radiotherapy (SRT). The majority of RT (63%, n = 51) was delivered with concurrent ICI. Acute neurological Adverse Events (AE) ≥ grade 3 occurred for 12.3% of RT course, with no difference between concurrent and non – concurrent groups. The median OS after RT was 11.5 months for the entire cohort with 15.9 months for SRT in comparison to 2.7 months for WBRT. The objective response rate was significantly better for concurrent ICI – SRT group at 66.7% compared to 40% for non-– concurrent group (p = 0.04). One-year LC probability was higher in the concurrent group than in the non-concurrent group, respectively 72. % vs 38.5% (p = 0.007).
CONCLUSIONS
Combined RT and ICI is well tolerated with acceptable neurological adverse events. Stereotactic radiation therapy delivered concurrently with ICI is associated with improved local control.
Pulmonary Function Test induction Jacket - A device which reduces the effort related challenges during Forced Vital Capacity maneuver.
Authors: Rajdeep Prashant , Poorey Ketaki , Patel RK , Oommen ER 
Published: May 2022

Abstract
Background- Over the last few years, the prevalence of lung function abnormalities has led to several mass testing programs across the world. PFT induction jacket has been invented as a small step towards making the process of performing FVC maneuver effortless and productive for both the patients and the medical practitioner.Method- The jacket is made up of a three-layered PVC sheet sealed together to form a single jacket with two chambers. The inner chamber is formed between an inner layer and middle layer, in which, when triggered cold water of 10 degree is circulated using connected water unit. Like ways, an outer chamber where air is pressurised using connected air unit is formed between middle layer and outer layer. Thirty volunteers performed FVC maneuver with and without wearing jacket.Results- There was no difference between the results in spirometry parameters ‘without jacket’ and ‘with jacket’. However, Median ± IQR (Q3-Q1) for the number of trials, which a participant had to undergo to perform spirometry was 3 ± 2 (4-2) (without jacket) and 1 ± 1 (2-1) (with jacket) and this difference was statistically significant (Wilcoxon signed rank test z = 4.129, p < 0.0001), which shows the jacket’s usefulness in performing FVC maneuver. Conclusion- PFT induction jacket has automated the FVC maneuver of computerized Spirometer by triggering physiological inspiratory gasp using cold water and circumscribing pressurised air for expiration. Induction jacket makes the maneuver easy to perform, time efficient and effortless for the patient.
Career opportunities and challenges of orthodontists graduated in the UAE
Authors: Buhamer Balquees , Ferguson Donald , Allam Eman 
Published: May 2022

Abstract
Aim: To assess the UAE orthodontics graduates and alumni professional career opportunities as well as challenges facing them. In addition, the impact of their postgraduate clinical and research training on their current job satisfaction and their future career plans was also explored.Methods: A questionnaire was sent online to a sample of 132 dentists representing all orthodontics specialists graduating from UAE based programs. Survey data were collated for 13 queries related to “job satisfaction” (6 queries) and “impact of the educational program from which they graduated” (7 queries). Likert scales were used to record responses. The ordinal responses to the 13 queries were assessed according to subgroup breakdowns in relation to demographics and current position satisfaction using non‐parametric testing. Results: Thirty-seven graduates responded to the online survey (28% response rate). Job satisfaction rate averaged (3.72) and was significantly lower than the impact of the educational program response (average 4.37). About 90% employability rate was reported. Orthodontists currently working in the UAE were significantly less satisfied with their jobs than orthodontists working outside the UAE when queried about salary and benefits, positive and supportive work environment and overall job satisfaction. Orthodontists who never moved since taking their initial job were less satisfied with salary and benefits as well as a positive and supportive work environment. Conclusion: While several factors might currently be considered essential elements for the higher education institutes quality assessment, their efforts in preparing their graduates to joining the workforce and improving their chances in career development and opportunities would be the most valuable from the postgraduates’ perspectives specifically in practice-focused degrees such as clinical specialities in dentistry. Majority of the orthodontics specialists graduated from UAE speciality programs are satisfied with their current job and the way their educational program prepared them.
Evaluating The Relation of Time Spent On Internet and Video Games On Ambulatory Blood Pressure Monitoring Parameters In Children And Adolescents
Authors: YETİŞGİN Hande , İNÖZÜ Mihriban , ÇÖP Esra , ÖZLÜ Sare Gülfem 
Published: May 2022

Abstract
Purpose: In this study, we aimed to determine the role of internet addiction and video games in blood pressure elevation in children and adolescents by evaluating ambulatory blood pressure monitoring measurements.Patients and Methods: This study was carried out with the patients who were referred to our pediatric nephrology out patient clinic for evaluation of hypertension. Children aged between 12 and 18 years old were included in the study. Patients with chronic kidney disease, chronic heart disease, endocrinological diseases, psychiatric diseases were excluded from the study. Demographic data, clinical and laboratory findings of the patients were obtained from hospital records. Ambulatory blood presssure monitoring was performed to evaluate hypertension. Young Internet Addiction Scale and Video Game Scale scores and ABPM parameters were compared.Results: Of the 107 patients included in our study, 40 were girls and 67 were boys. The mean age was 14.9±1.8 years. According to ABPM measurements, 43 (40.2%) of 107 patients were normotensive, 24 (22.4%) prehypertensive, and 40 (37.4%) hypertensive. We detected that as the test scores increased, the overall mean systolic blood pressure increased, but it did not reach a statistically significant state. As Young's Internet Addiction test score increased, the maximum daytime systolic blood pressure and mean daytime systolic blood pressure increased. Conclusion: Sedentary life style has increased the frequency of hypertension along with obesity. Both video game playing and increased time spent on the Internet; increase sedentary life and obesity and may also lead to the development of hypertension indepently from obesity. Therefore, we think that problematic internet use and video game playing disorders should be evaluated when investigating hypertensive children and adolescents.
Determination of Polychlorinated Dibenzo-p-Dioxins and Furans in Food Samples by Gas Chromatography-Triple Quadrupole Mass Spectrometry (GC- MS/MS) and Comparison with Gas Chromatography-High Resolution Mass Spectrometry (GC-HRMS)
Authors: Lyu Bing , Zhang Xiaoyan , Zhang Lei , Zhong Yuxin , Wu Yongning , Li Jingguang 
Published: May 2022

Abstract
Although gas chromatography–triple quadrupole mass spectrometry (GC-MS/MS) has been applied to the determination of polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) in various food samples, there is insufficient evidence to evaluate its equivalence with gas chromatography–high resolution mass spectrometry (HRMS). In the present study, two GC-MS/MS instruments with different ion sources (advanced electron ionization [AEI] and atmospheric pressure chemical ionization [APCI]) were evaluated for detecting trace levels of PCDD/Fs in various foods. GC-AEI-MS/MS and GC-APCI-MS/MS showed good linear relationships for 17 PCDD/Fs (0.01–200 ng/mL, R2 > 0.999), and the relative standard deviations of the relative response factors were 3–18%. The limit of quantitation range of the PCDD/Fs was 0.005–0.101 ng/mL with GC-APCI-MS/MS and 0.006–0.201 ng/mL with GC-AEI-MS/MS. The capabilities of the GC-MS/MS methods were evaluated for determination of PCDD/Fs in reference materials and real food samples. Statistical analyses showed that the toxic equivalents (TEQs) were comparable to those obtained with GC-HRMS, and the methods had good sensitivity, repeatability, and reproducibility. No difference was found between the results from the GC-MS/MS techniques and GC-HRMS when the PCDD/Fs concentrations were greater than 10− 2 pg/g. The results suggest that when the total TEQ is greater than 0.57 pg TEQ/g (lipid weight) or 0.052 pg TEQ/g (wet weight), GC-MS/MS techniques could be used as a complementary approach to GC-HRMS. Both GC-AEI-MS/MS and GC-APCI-MS/MS have similar sensitivity, selectivity, and stability to HRMS and could be used as confirmation methods for the analysis of trace PCDD/Fs in animal foods.
Image blind deblurring network with back projection feature fusion
Authors: Li Chi , Kong Weiwei , Xue Jiawei , Wang Ze , Chang Liang 
Published: May 2022

Abstract
Aiming at the problem of image motion blur caused by hand-held camera jitter and object motion in the process of collecting photos, a generative adversarial network (GAN) based on feature fusion of back projection is proposed for blind image deblurring. Firstly, the generator network is established by using U-Net structure, and a feature fusion residual block based on back projection is designed according to the error feedback principle, which solves the problem of saving spatial information in U-Net structure. Secondly, the self-attention module is introduced into the generator network to extract the feature map that pays more attention to detail. Finally, the combination of perceptual loss, mean square error loss and relative generative adversarial loss effectively alleviates the mode collapse problem of traditional GAN and improves the stability of model training. The experimental results show that the peak signal to noise ratio (PSNR) and structural similarity (SSIM) of this method on GoPro data set are 30.183dB and 0.941 respectively, and 26.962 and 0.837 on the Kohler dataset, with the shortest running time, which are better than the existing mainstream methods. The restored image is clearer in subjective vision and richer in texture details, which can effectively improve the image deblurring effect.
Identification of a Novel Compound Heterozygous Mutation of PHGDH in Neu–Laxova Syndrome
Authors: Li Huan , Yu Wen-Qian , Wei Jun , Liu Cai-Xia , Lyu Yuan 
Published: May 2022

Abstract
Background
Neu–Laxova syndrome (NLS) is an autosomal recessive genetic disease characterized by a variety of congenital malformations. It is a fatal developmental disorder caused by homozygous or compound heterozygous mutations in PHGDH, PSAT1, and PSPH.
Method
In this study, we aimed to characterize the clinical and molecular features of a fetus with NLS caused by novel heterozygous missense variants in PHGDH that were identified in his non-consanguineous parents. The fetus showed severe intrauterine growth restriction and abnormal ultrasound signs at 28 weeks of gestation. Fetal muscular tissue and peripheral blood samples from both parents were collected for whole-exome sequencing and Sanger sequencing.
Results
The clinical features were consistent with a diagnosis of NLS. Three missense mutations were detected in PHGDH in the fetus: c.488G > A(p.Arg163Gln) was carried by the father and c.607A > T(p.Ile203Phe) and c.743C > T (p.Ala248Val) were carried by the mother, resulting in a compound heterozygous mutation. Clinvar database suggests that c.743C > T may be benign variation, So we speculate that c.607A > T(p.Ile203Phe) is the pathogenic site carried by the mother.
Conclusions
This is the first report of PHGDH mutations in a patient with NLS in Northeast China. Thus, we detected a novel compound heterozygous pathogenic mutation in PHGDH, thereby expanding the molecular and phenotypic spectrum and providing strong support for the contribution of PHGDH to the pathogenesis of NLS.
Investigation and Modulation of Interleukin 6 following Subarachnoid Hemorrhage: Targeting Inflammatory Activation for Cerebral Vasospasm
Authors: Lucke-Wold Brandon , Dodd William , Motwani Kartik , Hosaka Koji , Laurent Dimitri , Martinez Melanie , Dugan Victoria , Chalouhi Nohra , Johnson Richard , Hoh Brian 
Published: May 2022

Abstract
Background: Cerebral vasospasm (CV) can contribute significant morbidity for subarachnoid hemorrhage (SAH) patients. A key unknown is how CV induction is triggered following SAH. Methods: human aneurysmal blood was collected for evaluation. To confirm mechanism, c57/bl6 wild type and c57/bl6 IL-6 female knockout (KO) mice were utilized with groups: saline injected, SAH, SAH + IL-6 blockade, SAH IL-6 KO, SAH IL-6 KO + IL-6 administration. For SAH, 50mm blood was collected from tail puncture and administered into basal cisterns. IL-6 blockade was given at various time points. Various markers of neuroinflammation were measured with western blot and immunohistochemistry. Cerebral blood flow was also measured. Vasospasm was measured via cardiac injection of india-ink/gelatin. Turning test and Garcia’s modified SAH score were utilized. P<0.05 was considered significant. Results: IL-6 expression peaked 3 days following SAH (p<0.05). Human IL-6 was increased in aneurysmal blood (p<0.05). Receptor upregulation was periventricular and perivascular. A significant increase in BBB markers endothelin 1 and occludin were noted following SAH but reduced with IL-6 blockade (p<0.01). CV occurred 5 days post SAH but was absent in IL-6 KO mice and mitigated with IL-6 blockade (p<0.05). IL-6 blockade, and IL-6 KO mitigated effects of SAH on cerebral blood flow (p<0.05). SAH mice had impaired performance on turn test and poor Modified Garcia Scores compared to saline and IL-6 blockade. A distinct microglia phenotype was noted day 5 in the SAH group (overlap coefficients r=0.96 and r=0.94) for Arg1 and iNOS, which was altered by IL-6 blockade. Day 7, a significant increase in toll-like receptor 4 and Stat3 were noted. This was mitigated by IL-6 blockade and IL-6 KO, which also reduced Caspase 3 (p<0.05). Ventricular dilation and increased tunel positivity were noted day 9 but resolved by IL-6 blockade (p<0.05). Conclusion: correlation between IL-6 and CV has been well documented. We show that a mechanistic connection exists via the inflammatory response, and IL-6 blockade provides benefit in reducing CV and its consequences.