bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Pandemisinin Sağlık Hizmetlerinin Sürdürülebilirliğine Etkisinin İncelenmesi
Authors: KIYMIŞ İbrahim , AKBULUT Meryem , KAYA Afşin Ahmet 
Published: June 2022

Küreselleşmenin hayatımızı kolaylaştıran olumlu etkilerinin yanı sıra olumsuz etkileri de farklı bağlamlarda etkisini göstermiştir. Küreselleşmenin olumsuz etkilerinin son örneği, tüm dünyayı ve tüm toplumları derinden etkileyen COVID-19 pandemisi olmuştur. COVID-19 pandemisi özellikle sağlık hizmetlerini olumsuz etkilemiştir. Bu çerçevede bu çalışmanın amacı, COVID-19 pandemi sürecinin sağlık hizmetlerinin sunumuna olan etkisini değerlendirmektir.
Bu araştırmanın örneklemi seçilirken amaçlı örnekleme yöntemlerinden biri olan ölçüt örnekleme kullanılmıştır. Sağlık hizmetleri sektöründe faaliyet gösteren kurum yöneticileri ile operasyonel müdahaleler, lojistik ve kaynak yönetimi, kurumlar arası koordinasyon, iş sağlığı ve güvenliği, planlama ve finansal yönetim gibi konularda açık uçlu sorulardan oluşan yarı yapılandırılmış bir form kullanılarak görüşülmüştür.
Bazı yöneticiler, özellikle küçük ölçekli hastanelerin afet ve acil durumlara hazırlıklı olmadığını belirterek, planlamanın ve hazırlıklı olmanın önemine vurgu yapmıştır. Bu bilgiler ışığında, her hastanenin Hastane Afet ve Acil Durum Planlarına gereken özeni göstermeleri ve tüm personeli sürece dahil ederek gerekli hazırlıkları yapmaları şarttır. Planlama ve hazırlıklı olmanın temeli hem teorik hem de pratik olarak ele alınması gereken tatbikatlardır. Hastanelerin en olası riskleri içeren afet ve acil durum senaryoları oluşturmaları ve bu yönde tatbikatlar yapmaları gerekmektedir. Senaryonun gerçek olması durumunda beklenmedik durumlarla karşılaşmamak için gerçekçi senaryolar oluşturulmalı ve bu senaryolar tüm yönleriyle ele alınmalıdır. Tatbikatlar her yıl aynı senaryoya dayanmamalıdır. Ayrıca her yıl müdahale seviyesi artırılmalı ve mevcut kapasiteler yeniden değerlendirilmelidir.
PREDICTING KIDNEY TUMOR SUBTYPE FROM CT IMAGES USING RADIOMICS AND CLINICAL FEATURES
Authors: ŞİRİN Duygu , GÜVENİŞ Albert 
Published: June 2022

Purpose: This study aims to evaluate the performance of machine learning methods in predicting the subtype (clear-cell vs. non-clear-cell) of kidney tumors using clinical patient and radiomics data from CT images.
Method: CT images of 192 malignant kidney tumor cases (142 clear-cell, 50 other) from TCIA’s KiTS-19 Challenge were used in the study. There were several different tumor subtypes in the other group, most of them being chromophobe or papillary RCC. Patient clinical data were combined with the radiomic features extracted from CT images. Features were extracted from 3D images and all of the slices were included in the feature extraction process. Initial dataset consisted of 1157 features of which 1130 were radiomics and 27 were clinical. Features were selected using Kruskal Wallis – ANOVA test followed by Lasso Regression. After feature selection, 8 radiomic features remained. None of the clinical features were considered important for our model as a result. Training set classes were balanced using SMOTE. Training data with the selected features were used to train the Coarse Gaussian SVM and Subspace Discriminant classifiers.
Results: Coarse Gaussian SVM was faster compared to Subspace Discriminant with a training time of 0.47 sec and ~11000 obs/sec prediction speed. Training duration of Subspace Discriminant was 4.1 sec with ~960 obs/sec prediction speed. For Coarse Gaussian SVM; validation accuracy was 67,6% while the accuracy of test was 80%, with and AUC of 0.86. Similarly, Subspace Discriminant had 68,8% validation accuracy and 80% test accuracy; AUC was 0.85.
Conclusion: Both models produced promising results on classifying malignant tumors as ccRCC or non-ccRCC. However, Coarse Gaussian SVM might be more preferable because of its training and prediction speed.
Transit Timing Variations for AU Microscopii b and c
Authors: Wittrock Justin M. , Dreizler Stefan , Reefe Michael A. , Morris Brett M. , Plavchan Peter P. , Lowrance Patrick J. , Demory Brice-Olivier , Ingalls James G. , Gilbert Emily A. , Barclay Thomas , Cale Bryson L. , Collins Karen A. , Collins Kevin I. , Crossfield Ian J. M. , Dragomir Diana , Eastman Jason D. , Mufti Mohammed El , Feliz Dax , Gagné Jonathan , Gaidos Eric , Gao Peter , Geneser Claire S. , Hebb Leslie , Henze Christopher E. , Horne Keith D. , Jenkins Jon M. , Jensen Eric L. N. , Kane Stephen R. , Kaye Laurel , Martioli Eder , Monsue Teresa A. , Pallé Enric , Quintana Elisa V. , Radford Don J. , Roccatagliata Veronica , Schlieder Joshua E. , Schwarz Richard P. , Shporer Avi , Stassun Keivan G. , Stockdale Christopher , Tan Thiam-Guan , Tanner Angelle M. , Vanderburg Andrew , Vega Laura D. , Wang Songhu 
Published: June 2022

Abstract
We explore the transit timing variations (TTVs) of the young (22 Myr) nearby AU Mic planetary system. For AU Mic b, we introduce three Spitzer (4.5 μm) transits, five TESS transits, 11 LCO transits, one PEST transit, one Brierfield transit, and two transit timing measurements from Rossiter–McLaughlin observations; for AU Mic c, we introduce three TESS transits. We present two independent TTV analyses. First, we use EXOFASTv2 to jointly model the Spitzer and ground-based transits and obtain the midpoint transit times. We then construct an O − C diagram and model the TTVs with Exo-Striker. Second, we reproduce our results with an independent photodynamical analysis. We recover a TTV mass for AU Mic c of

10.8

−
2.2

+
2.3

M
⊕. We compare the TTV-derived constraints to a recent radial velocity (RV) mass determination. We also observe excess TTVs that do not appear to be consistent with the dynamical interactions of b and c alone or due to spots or flares. Thus, we present a hypothetical nontransiting “middle-d” candidate exoplanet that is consistent with the observed TTVs and candidate RV signal and would establish the AU Mic system as a compact resonant multiplanet chain in a 4:6:9 period commensurability. These results demonstrate that the AU Mic planetary system is dynamically interacting, producing detectable TTVs, and the implied orbital dynamics may inform the formation mechanisms for this young system. We recommend future RV and TTV observations of AU Mic b and c to further constrain the masses and confirm the existence of possible additional planet(s).
Disks in Nearby Young Stellar Associations Found Via Virtual Reality
Authors: Higashio Susan , Kuchner Marc J. , Silverberg Steven M. , Brandt Matthew A. , Grubb Thomas G. , Gagné Jonathan , Debes John H. , Schlieder Joshua , Wisniewski John P. , Slocum Stewart , Bans Alissa S. , Bhattacharjee Shambo , Biggs Joseph R. , Bosch Milton K. D. , Cernohous Tadeas , Doll Katharina , Durantini Luca Hugo A. , Enachioaie Alexandru , Griffith Phillip , Hamilton Joshua , Holden Jonathan , Hyogo Michiharu , Jung Dawoon , Lau Lily , Piñeiro Fernanda , Piipuu Art , Stiller Lisa ,   The Disk Detective Collaboration
Published: June 2022

Abstract
The Disk Detective citizen science project recently released a new catalog of disk candidates found by visual inspection of images from NASA’s Wide-field Infrared Survey Explorer mission and other surveys. We applied this new catalog of well-vetted disk candidates to search for new members of nearby young stellar associations (YSAs) using a novel technique based on Gaia data and virtual reality (VR). We examined AB Doradus, Argus, β Pictoris, Carina, Columba, Octans-Near, Tucana–Horologium, and TW Hya by displaying them in VR together with other nearby stars, color coded to show infrared excesses found via Disk Detective. Using this method allows us to find new association members in mass regimes where isochrones are degenerate. We propose 10 new YSA members with infrared excesses: three of AB Doradus (HD 44775, HD 40540 and HD 44510), one of β Pictoris (HD 198472), two of Octans-Near (HD 157165 and BD+35 2953), and four disk-hosting members of a combined population of Carina, Columba, and Tucana–Horologium: CPD-57 937, HD 274311, HD 41992, and WISEA J092521.90-673224.8. This last object (J0925) appears to be an extreme debris disk with a fractional infrared luminosity of 3.7 × 10−2. We also propose two new members of AB Doradus that do not show infrared excesses: TYC 6518-1857-1 and CPD-25 1292. We find HD 15115 appears to be a member of Tucana–Horologium rather than β Pictoris. We advocate for membership in Columba–Carina of HD 30447, CPD-35 525, and HD 35841. Finally, we propose that three M dwarfs, previously considered members of Tucana–Horologium are better considered a separate association, tentatively called “Smethells 165”.
Azithromycin treatment failure and macrolide resistance in Mycoplasma genitalium infections in Sofia, Bulgaria
Authors: Philipova Ivva , Levterova Viktoryia , Simeonovski Ivan , Kantardjiev Todor 
Published: June 2022

Introduction: Mycoplasma genitalium is an established cause of sexually transmitted infections in men and women. Current guidelines recommend azithromycin and moxifloxacin as first- and second-line treatment, respectively. However, azithromycin treatment failure has been increasingly reported. The aim of this study was to determine the efficacy of azithromycin and alternative antibiotic regimens in a prospective cohort of M. genitalium-positive patients, and macrolide resistance mutations associated with azithromycin failure.
Materials and methods: Consecutive eligible M. genitalium-positive patients attending the National Center of Infectious and Parasitic Diseases in Sofia, Bulgaria between 1 January 2018 and 31 December 2020 were treated with azithromycin and retested by polymerase chain reaction 21-28 days after completion of the treatment. Cure was defined as M. genitalium-negative result on the test of cure. Cases failing azithromycin were treated with moxifloxacin and retested another 21-28 days after treatment. Pre- and post-treatment samples were assessed for macrolide resistance mutations by conventional DNA sequencing.
Results: Of 21 patients treated with azithromycin, 11 (52.4%) were cured. Pre- and post-treatment macrolide resistance mutations were detected in 10 (47.6%) patients, and all of them failed azithromycin. Moxifloxacin was effective in all cases failing azithromycin; and all were M. genitalium-negative at the test of cure after moxifloxacin treatment.
Conclusions: In this study a high azithromycin failure rate (47.6%) in an M. genitalium-positive cohort in association with high levels of pretreatment macrolide resistance was reported. Moxifloxacin was highly effective in treating macrolide-resistant infections. These findings necessitate implementation of new diagnostic and therapeutic strategies such as sequential antimicrobial therapy for M. genitalium guided by a macrolide-resistance assay.
Prophylactic central lymph node dissection in differentiated thyroid cancer – benefits and risk
Authors: Kostov Gancho G. , Dimov Rossen S. , Doykov Mladen I. 
Published: June 2022

Introduction: Papillary thyroid cancer is the most common thyroid malignancy. Lymph nodes involvement is common in differentiated thyroid cancer, and cervical lymph node micrometastases are observed in up to 85% of patients with papillary thyroid cancer during surgery. While the therapeutic central lymph node dissection has been accepted, the debate on the prophylactic in differentiated thyroid carcinoma (DTC) continues.
Aim: To evaluate the benefits and risk of prophylactic central lymph node dissection in differentiated thyroid cancer.
Materials and methods: Between January 2014 and December 2018, 223 total thyroidectomies due to papillary thyroid cancer were performed in the Kaspela University Hospital in Plovdiv. The patients were allocated into two groups: group A consisting of 36 patients with total thyroidectomy alone, and group B - 178 patients with total thyroidectomy and prophylactic central lymph node dissection.
Results: In 36 (21.6%) patients, we found metastases only in ipsilateral side. In 24 (13.4%) of them we found metastatic spread in both ipsilateral and contralateral lymph nodes. In 7 (3.9%) patients, the metastasis was found only in the contralateral nodes. A pre-laryngeal lymph node was found and removed in 79 patients. Metastases were found in 12 of these 79 nodes. Analysis of complications showed no significant differences in its rate in patients with TT+ PCLND vs. patients with TT alone.
Conclusions: The present study suggests that the realization of total thyroidectomy with prophylactic central lymph node dissection in papillary thyroid cancer patients has neither substantial advantages nor significant complications for the short period of observation.
Daily iron intake and BMI for age but not for daily tannin intake increase hemoglobin levels in young females at Karanganyar Regency, Central Java, Indonesia
Authors: Ilmiyati Liyana , Indarto Dono , Wasita Brian 
Published: June 2022

Abstract

Introduction: Prevalence of anemia among young women in Indonesia has been seen to increase in the last five years. This situation indicates that this nutritional disorder looks like an iceberg phenomenon. Daily consumption of vegetables containing foods is recommended for prevention of non-communicable diseases including anemia. These foods contain not only ferric ions but also other natural compounds.
Aim: To analyse the relationship of daily intake of micronutrients and polyphenols with hemoglobin levels in young females.
Materials and methods: This cross-sectional study recruited 117 young females who studied in six senior high schools in Karanganyar Regency, Central Java; they were selected using a purposive sampling. Data of micronutrients and polyphenols intake were collected using the Semi Quantitative-Food Frequency questionnaire. Blood samples from lower arm veins were used for hemoglobin measurements in a hematology analyser. The collected data were analysed using the Rank Spearman and multiple regression linear tests to evaluate the relationship of micronutrients and polyphenols intake with the hemoglobin levels.
Results: The prevalence of anemia was 17.1% among 20/117 young females. Higher dietary intake of iron (b=0.043; p&lt;0.001) and higher BMI for age (b=0.246; p=0.025) increased the Hb levels while higher dietary intake of tannin (b=−0.003; p=0.009) decreased them.
Conclusions: Dietary intake of iron and BMI for age are related to the hemoglobin levels but tannin intake is inversely related to these levels in young females. Higher iron intake from vegetable resources should be taken into account for anemia reduction in young females due to the presence of tannins.
Pitfalls in the reporting of neoplastic and pseudo neoplastic lesions in the colon and rectum
Authors: Al Qudah Mohammad , Haboubi Najib 
Published: June 2022

Introduction: Colonic biopsies comprise large portion of pathologists’ daily work. Within various pathological entities, there are histological ranges and variations. Unawareness of all of these variabilities might lead to misdiagnosis by an inexperienced pathologist and, accordingly, to mismanagement.
Aim: The aim of this article was to alert the reporting pathologist to some of the most common and/or important pitfalls in considering a diagnosis of neoplastic conditions of the colon.
Materials and methods: We highlighted main neoplastic pitfalls in colonic biopsies histopathological investigations.
Results: The pitfalls described in this article are the most common problems we encountered according to our experience. Thus, double reporting for difficult cases is highly recommended to avoid problems in reporting such cases.
Conclusions: Pathologist should be fully alert when reporting some of the most common pitfalls.
La léthargie : une contribution à l’étude de la réaction thérapeutique négative
Authors: Cesio Fidias R. , Assan Jean-Michel 
Published: June 2022

L’auteur décrit la présence d’« objets léthargiques » dans l’inconscient des patients qui présentent une réaction thérapeutique négative, et une activité du moi qui tend à produire et à maintenir la paralysie de ces objets. L’objet « léthargisé » est équivalent au noyau psychotique, ainsi qu’au moi prénatal du malade. Cet objet interne est intensément éprouvé par l’analyste dans son contre-transfert. Ces idées sont illustrées par l’histoire d’un patient qui présentait une réaction thérapeutique négative.
Pour un système de santé français intégré
Authors: El Saïr Philippe , Lebée-Thomas Émilie , Malone Antoine 
Published: June 2022

Plus de deux ans de pandémie de Covid ont grandement éprouvé les systèmes de santé de la plupart des pays du monde. En France, si le personnel a fait face, c’est au prix d’un épuisement physique et moral des soignants, qui appellent régulièrement à une refonte du système. À l’échelle locale, la pénurie de praticiens et le développement des déserts médicaux sont régulièrement évoqués parmi les principales préoccupations des citoyens. À n’en pas douter la réforme du système de santé français devrait figurer en bonne place dans les enjeux du quinquennat qui vient de commencer. Pour alimenter les réflexions sur ce sujet, cet article de Philippe El Saïr, Émilie Lebée-Thomas et Antoine Malone propose une piste nouvelle consistant à mettre en place un système intégré optimisant l’offre de soins et les dépenses afférentes à des échelles territoriales spécifiques. Les auteurs, tous praticiens hospitaliers de haut niveau, se fondent ici sur un modèle de coopération actuellement en cours d’expérimentation dans cinq territoires français, s’inspirant d’expériences en vigueur dans d’autres pays. Au cœur du projet figurent quatre objectifs : meilleure prise en charge des patients, meilleure santé de la population concernée, meilleur emploi des ressources budgétaires, enfin, meilleures conditions de travail des soignants. Après avoir rappelé ce que recouvre la notion d’intégration de l’offre de santé et présenté les modèles ayant déjà fait leurs preuves, de manière soit verticale (Kaiser Permanente en Californie, National Health System anglais), soit horizontale (Gesundes Kinzigtal en Allemagne, organisations de soins responsables [ACO] aux États-Unis, Intégreo en Belgique), les auteurs montrent comment on pourrait mettre en place une telle intégration au sein du système de santé en France. Partant des expériences pionnières, ils précisent l’échelle territoriale optimale, les freins à lever et les atouts à mobiliser, ainsi que les prérequis pour une généralisation d’un modèle intégré à l’échelle nationale. S.D.
Idéaux, valeurs et nécessités économiques
Authors: Cusset Pierre-Yves 
Published: June 2022

Début 2022 est paru un ouvrage qu’auraient grand intérêt à lire nos gouvernants et ceux qui les conseillent, en particulier en matière économique : Le Prix de nos valeurs. Quand nos idéaux se heurtent à nos désirs matériels, d’Augustin Landier et David Thesmar. Les auteurs s’y penchent sur le décalage manifeste entre l’opinion des économistes (qui souvent nourrit la décision publique) et celle des individus « ordinaires », animés par leurs idéaux, leurs valeurs, mais aussi leurs aspirations et contraintes matérielles, parfois contradictoires. « Les vrai[e]s gens s’avèrent fort différent[e]s de l’ Homo œconomicus, ce robot froid et excellent calculateur des manuels d’économie », écrivent-ils. Cet écart pourrait expliquer la défiance croissante vis-à-vis de l’expertise et alimenterait, selon les auteurs, la montée des populismes, extrémismes ou de l’abstention, et par extension, l’affaiblissement des démocraties. Pierre-Yves Cusset a lu cet ouvrage et en résume ici les principaux enseignements, à commencer par ce décalage entre les valeurs des économistes et celles du reste du monde, illustré par de nombreux exemples concrets et particulièrement parlants (en matière de libre-échange, d’immigration, d’héritage, etc.). Puis il présente les résultats de l’enquête internationale qui sert, dans la deuxième partie du livre, à évaluer les aspirations des individus selon le coût économique des options qui leur sont proposées — permettant d’appréhender les compromis qu’ils seraient prêts à faire (ou non) entre leurs principes moraux et la réalité économique. In fine , en dépit des certitudes qui peuvent animer beaucoup d’économistes, ceux-ci n’ont pas le monopole de la bonne décision, et les citoyens sont les seuls légitimes pour faire leurs choix économiques, selon une rationalité qui leur est propre et dont il faut tenir compte. S.D.
La longue marche vers l’Union européenne
Authors: Papon Pierre 
Published: June 2022

L’entrée en guerre de la Russie en Ukraine fin février 2022 a réveillé les souvenirs douloureux d’une époque où l’Europe vivait au rythme des guerres et des dissensions entre voisins. Alors que le Vieux Continent pensait être pacifié, à la faveur de la construction de l’Union européenne et de ses élargissements successifs à la plus grande partie du continent, ce retour de la guerre sur le sol européen et aux frontières de l’Union inquiète. Il montre aussi les vulnérabilités qui demeurent dans l’Union, à la fois en matière de défense militaire et en termes de dépendance énergétique. Et sur ces deux aspects, le conflit russo-ukrainien pourrait bien inciter les pays européens à faire un pas de plus dans leur intégration politique. Une intégration politique que préconisait déjà Victor Hugo au milieu du XIX e siècle, appelant au rapprochement des pays européens dans une « unité supérieure », en matière tant économique que politique. L’écrivain français qui prônait déjà une forme de fédéralisme sera finalement suivi, deux ou trois guerres plus tard, au cours du XX e siècle, par les pères fondateurs de la Communauté européenne (Robert Schuman, Jean Monnet en particulier). C’est ce que rappelle Pierre Papon, dans ce Futur d’antan, en reprenant de larges extraits de ces discours fondateurs qui ont conduit l’Europe à se construire, à petits pas, par l’interdépendance économique ; en attendant l’étape d’une véritable intégration politique ? S.D.
L’Ukraine, 28 e État membre ?
Authors: Drevet Jean-François 
Published: June 2022

Il est difficile de savoir où en sera le conflit russo-ukrainien au moment où paraîtra ce numéro d’été, mais à l’heure de le boucler, il y a peu de chances que la situation soit revenue à ce qu’elle était en février 2022. Les frontières de l’Ukraine auront-elles encore bougé comparées à celles de 2014, avant l’annexion de la Crimée par la Russie ? Les troupes de Vladimir Poutine auront-elles reculé ? Mais si le président Volodymyr Zelensky est encore en place, les discussions relatives à une possible entrée de l’Ukraine dans l’Union européenne conserveront toute leur actualité. Une telle perspective est-elle envisageable ? Selon quelles modalités et quel calendrier ? Dans cette chronique européenne, Jean-François Drevet remet la demande d’adhésion rapide ( fast track ) de l’Ukraine à l’Union en perspective, à la fois sur le plan géopolitique et sur le plan institutionnel. Il rappelle en particulier combien les processus d’adhésion sont longs et complexes (plusieurs pays des Balkans patientent dans l’antichambre de l’adhésion depuis déjà plusieurs années), et nécessitent une préparation et une négociation minutieuses entre le candidat et l’Union ; il souligne aussi le contexte très particulier lié aux ambitions et à la conception sécuritaire du voisin russe. Autant d’éléments qui ne plaident pas en faveur de ce « fast track », mais plutôt d’un renforcement de l’aide financière et matérielle à l’Ukraine dans son combat contre la Russie, avant — une fois la situation stabilisée — d’envisager la demande d’adhésion de Kiev selon le processus habituel suivi par l’Union jusqu’à présent, éventuellement précédé d’une association renforcée. S.D.