bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of myocardial scar burden on microvascular resistance reserve in patients with coronary artery disease
Authors: Hoshino Masahiro , Hoek Roel , Jukema Ruurt. A. , Dahdal Jorge , van Diemen Pepijn , Hopman Luuk H. G. A. , Raijmakers Pieter , Driessen Roel , Twisk Jos , Danad Ibrahim , Kakuta Tsunekazu , Knuuti Juhani , Knaapen Paul 
Published: February 2025

Abstract

Purpose
The impact of myocardial scar on coronary microcirculation is not well understood. This study aims to evaluate the association between microvascular resistance reserve (MRR) and scar tissue.

Methods
In this post-hoc analysis of the PACIFIC 2 trial, symptomatic patients with prior myocardial infarction (MI) and/or percutaneous coronary intervention (PCI) underwent [15O]H2O positron emission tomography (PET), cardiac magnetic resonance (CMR) imaging, and fractional flow reserve (FFR). MRR was assessed utilizing PET-derived coronary flow reserve and FFR measurements. Scar quantification was assessed by CMR late gadolinium enhancement (LGE). Vessel LGE burden was defined as the scar tissue proportion in each myocardial territory. Total LGE burden was defined as the proportion of overall scar.

Results
The study included 154 patients with 397 vessels with a mean MRR of 3.56 ± 1.24. Patients with any scar tissues (LGE > 0%) exhibited a lower MRR in every myocardial territory than those without scar tissues. After adjusting for cardiovascular risk factors, either vessel LGE burden (β =-0.013, P = 0.006) or total LGE burden (β =-0.039, P = 0.002) independently predicted a reduced MRR. Compared to myocardial territories without scar tissues (LGE burdens = 0%), MRR was significantly lower in myocardial territories with vessel LGE burden = 0% + total LGE burden > 0%, and in myocardial territories with both LGE burdens > 0%.

Conclusion
Scar burden was negatively associated with MRR in patients with prior MI and/or PCI. Our findings indicate that both the proportion of myocardial scar in the vascular territory and the overall myocardial scar affect the microcirculation of individual vascular territories.

Clinical trial number
Not applicable.
Denitrification in Agricultural Soils – Integrated control and Modelling at various scales (DASIM)
Authors: Kleineidam Kristina , Böttcher Jürgen , Butterbach-Bahl Klaus , Dannenmann Michael , Dittert Klaus , Dörsch Peter , Fiedler Sebastian , Frosch Torsten , Grosz Balázs , Henjes Sina , Horn Marcus A. , Ippisch Olaf , Jansen-Willems Anne , Kaiser Klaus , Kempe Miriam , Köster Jan Reent , Geers-Lucas Maik , Malique Franҫois , Matson Amanda , Merian Andreas , Mikutta Robert , Müller Carsten W. , Ramm Elisabeth , Rohe Lena , Rummel Pauline Sophie , Scheer Clemens , Schimpf Corinna M. , Schlüter Steffen , Schulze Johannes , Surey Ronny , Tenspolde Arne , van Dijk Hester , Vogel Hans-Jörg , Well Reinhard , Wrage-Mönnig Nicole , Yankelzon Irina , Zawallich Jan , Müller Christoph 
Published: February 2025

Abstract
The special issue summarises and highlights key findings of the research unit DASIM funded by the German Research Foundation (DFG) on the process of denitrification. Progress was made in several areas including the development of new and advanced methods to quantify N2 fluxes such as a new 15N gas flux method, enhanced Raman spectroscopy and a new incubation system to study plant-soil interactions in He-O2 atmosphere. Understanding of denitrification in disturbed and structured soil was gained by combining X-ray CT scanning and microbial ecology methods. High resolution models developed as part of DASIM were able to successfully simulate experimental data and provide valuable insights for the improvement of existing ecosystem models. Improved 15N tracing tools for the analysis of 15N tracing data in soil-plant systems have been developed that are extensively used by associated partners. DASIM brought together an interdisciplinary network of researchers interested in analytical but also modelling aspects. This includes close collaboration with the FAO/IAEA centre of Nuclear Techniques in Food and Agriculture of the United Nations which resulted in an open access book that describes the methods used in DASIM. The impact of the DASIM research unit on the scientific community is manifold and will most likely have a lasting impact on the understanding of nitrogen cycling in terrestrial ecosystems.
T2 high-signal-intensity zone of the spinal cord dorsal horn in patients treated with spinal cord stimulation for herpes zoster-associated pain: a retrospective case–control study
Authors: Arakawa Kyosuke , Nakagawa Masayuki , Abe Yoichiro , Morimatsu Hiroshi 
Published: February 2025

Abstract

Purpose
In patients with herpes zoster-associated pain (ZAP), magnetic resonance imaging (MRI) has revealed T2 high-signal intensity zones (MRI T2 HIZ) in the dorsal horn of the spinal cord, associated with postherpetic neuralgia (PHN). We retrospectively analyzed the relationship between PHN and MRI T2 HIZ in patients with refractory ZAP in the subacute phase who underwent temporary spinal cord stimulation therapy (tSCS).

Methods
This single-center, case–control study included patients who underwent tSCS for refractory ZAP between 2010 and 2018. MRIs were re-assessed for the presence of T2 HIZ in the dorsal horn of the spinal cord. Patients were divided into T2 HIZ( +) and T2 HIZ(−) groups. Patients with a numerical rating score (NRS) ≥ 3 at the last visit were defined as PHN. The NRS values and the incidence rate of PHN were compared between the two groups.

Results
Of the 67 cases extracted, 38 were included in the analysis: 22 in T2 HIZ( +) group and 16 in T2 HIZ(−) group. No significant differences were observed in background factors between the two groups. However, the T2 HIZ( +) group had a significantly higher NRS at the final visit (T2 HIZ( +):3.8 ± 2.1, T2 HIZ(−):1.4 ± 1.5; P < 0.05) and had significantly more patients with PHN than the T2 HIZ(−) group (T2 HIZ( +) vs. T2 HIZ(−), 15/22 (68%) vs. 3/16 (19%); odds ratio = 8.67; 95% confidence interval, 1.7–63.3).

Conclusion
T2HIZ is detected in more than half of refractory ZAP, and pain is more likely to remain after tSCS treatment in the T2HIZ( +) group.
Correlation between Sirtuin 1 downregulation and reduced vitamin D receptor expression in patients with diabetic neuropathy
Authors: Latini Andrea , De Benedittis Giada , Morgante Chiara , Gasperini Beatrice , D’Ippolito Ilenia , Lauro Davide , Novelli Giuseppe , Ciccacci Cinzia , Spallone Vincenza , Borgiani Paola 
Published: February 2025

Abstract

Aims
We aimed to analyse Sirtuin 1 (SIRT1) and Vitamin D receptor (VDR) expression levels in the peripheral blood of patients with type 2 diabetes (T2D), characterized for the presence of diabetic neuropathy (DN), and to evaluate possible genetic factors that could influence the VDR expression levels.

Methods
Fifty-one participants with T2D, who underwent neurological assessment for DN were recruited. We quantified the mRNA levels of SIRT1 and VDR in peripheral blood mononuclear cells. Moreover, we analysed the methylation status and the rs2228570 genetic variant of VDR promoter.

Results
Patients with DN (n = 32) showed lower expression of SIRT1 (pcorr=0.018) and VDR (pcorr=0.009), compared to those without DN. Furthermore, we observed a positive correlation between the mRNA levels of SIRT1 and VDR (p = 0.01). The expression levels of these genes negatively correlated with the score based on cardiovascular reflex tests (CARTs score). Moreover, the variant allele of rs2228570 in the VDR gene was associated with higher expression of this gene compared to the wild-type allele (p = 0.003).

Conclusion
In patients with DN, both SIRT1 and VDR expression levels are reduced and interrelated. Low VDR expression levels could negatively affect SIRT1 transcription, thus influencing all the most pathogenetic pathways of DN regulated by this protein.
A review of olivine as a tool for understanding kimberlite petrogenesis and diamond potential
Authors: Howarth Geoffrey H. , Casetta Federico , Abersteiner Adam 
Published: February 2025

Abstract
Olivine, the most abundant mineral in kimberlites, exhibits complex compositional zoning characterised by xenocrystic mantle-derived cores that are surrounded by numerous growth and equilibration zones. This review explores how olivine can be used to understand magma evolution, mantle sampling depths, and assess the diamond potential of kimberlites. Aluminium-in-olivine thermometry of xenocryst cores, calibrated against local geotherms, provides valuable insights into the peridotitic material sampled by kimberlites, including its diamond potential. By analyzing the relative abundance of peridotitic- versus megacrystic-derived olivine core zones in individual kimberlites, the extent of diamond-destructive preconditioning by proto-kimberlite melts within the sub-continental lithospheric mantle (SCLM) can be evaluated. Global compilations of mean core and rim compositions, along with groundmass modal abundances, help to understand the diversification of kimberlite melts through complex interactions with SCLM. Similarly, global data on cratonic olivine lamproites indicate that they evolved from sub-lithospheric melts, diversifying within the SCLM to produce the observed range of cratonic lamproite compositions. Crystal inclusions within olivine allow for the liquid line of descent to be constrained, and chemical gradients at the interface between cores and growth zones in olivine allow the application of chronometry models for estimating the ascent rate of kimberlites from the mantle to the surface. Additionally, primary and secondary melt/fluid inclusions offer snapshots of kimberlite melt compositions, tracing melt evolution across multiple stages. Thus, olivine allows for unprecedented insight into the nature of the SCLM sampled by kimberlite magmas, as well as their formation and evolution from source to surface.
Indigenous migrant labourers and land: towards an exploration of indigenous’ socio-cultural reproduction in the Colombian Altillanura
Authors: Arango Lorenza 
Published: February 2025

Abstract
Production and social reproduction are increasingly characterized by its multisitedeness given the rising number of working people migrating for wage work. The ways in which these spheres interplay, both at migrants’ places of origin and at the destination sites of work, differ greatly across societies. Based on primary research in Puerto Gaitán, Colombia—a small town in a largely rural area serving as an agribusiness and oil exploitation hub—I suggest that the complex expressions of the production-social reproduction nexus are intimately connected with the ‘politics of land’. While the town of Puerto Gaitán, as a place of migration, provides for most everyday ‘material’ elements to sustain life (food, shelter, clothing, care, schools, hospitals), other crucial aspects of social reproduction are still heavily performed at indigenous’ rural collective lands (resguardos). Resguardo lands are a key socio-cultural basis of Indigenous peoples’ reproduction, despite serious limitations partly due to their isolation, to restrictions on the free circulation by large landowners, and to historical underlying drivers founded in dispossession. One important analytical and political implication is that migrant workers’ access to land should respond to a broader conceptualization of social reproduction—i.e., in which non-material aspects are equally considered.
A deadly taste: linking bitter taste receptors and apoptosis
Authors: Miller Zoey A. , Carey Ryan M. , Lee Robert J. 
Published: February 2025

Abstract
Humans can perceive five canonical tastes: salty, sour, umami, sweet, and bitter. These tastes are transmitted through the activation of ion channels and receptors. Bitter taste receptors (Taste Family 2 Receptors; T2Rs) are a sub-family of 25 G-protein coupled receptor (GPCR) isoforms that were first identified in type II taste bud cells. T2Rs are activated by a broad array of bitter agonists, which cause an increase in intracellular calcium (Ca2+) and a decrease in cyclic adenosine 3’,5’-monophosphate (cAMP). Interestingly, T2Rs are expressed beyond the oral cavity, where they play diverse non-taste roles in cell physiology and disease. Here, we summarize the literature that explores the role of T2Rs in apoptosis. Activation of T2Rs with bitter agonists induces apoptosis in several cancers, the airway epithelia, smooth muscle, and more. In many of these tissues, T2R activation causes mitochondrial Ca2+ overload, a main driver of apoptosis. This response may be a result of T2R cellular localization, nuclear Ca2+ mobilization and/or a remnant of the established immunological roles of T2Rs in other cell types. T2R-induced apoptosis could be pharmacologically leveraged to treat diseases of altered cellular proliferation. Future work must explore additional extra-oral T2R-expressing tissues for apoptotic responses, develop methods for in-vivo studies, and discover high affinity bitter agonists for clinical application.
Concomitant medications in patients with metastatic urothelial carcinoma receiving enfortumab vedotin: real-world data from the ARON-2EV study
Authors: Fiala Ondřej , Buti Sebastiano , Fujita Kazutoshi , de Liaño Alfonso Gómez , Fukuokaya Wataru , Kimura Takahiro , Yanagisawa Takafumi , Giannatempo Patrizia , Angel Martin , Mennitto Alessia , Molina-Cerrillo Javier , Bourlon Maria T. , Soares Andrey , Takeshita Hideki , Calabrò Fabio , Ortega Cinzia , Kucharz Jakub , Milella Michele , Seront Emmanuel , Park Se Hoon , Tural Deniz , Benedetti Giovanni , Ürün Yüksel , Battelli Nicola , Melichar Bohuslav , Poprach Alexandr , Buchler Tomas , Kopecký Jindřich , Conteduca Vincenza , Monteiro Fernando Sabino Marques , Massari Francesco , Gupta Shilpa , Santoni Matteo 
Published: February 2025

Abstract
Patients with metastatic urothelial carcinoma (mUC) are typically elderly and often have other comorbidities that require the use of concomitant medications. In our study we evaluated the association of concomitant use of antibiotics (ATBs), proton pump inhibitors (PPIs), corticosteroids, statins, metformin and insulin with patient outcomes and we validated the prognostic role of a concomitant drug score in mUC patients treated with enfortumab vedotin (EV) monotherapy. Data from 436 patients enrolled in the ARON-2EV retrospective study were analyzed according to the concomitant medications used at baseline. Finally, the patients were stratified into three risk groups according to the concomitant drug score based on ATBs, corticosteroids and PPIs. Statistical analysis involved Fisher exact test, Kaplan–Meier method, log-rank test, and univariate/multivariate Cox proportional hazard regression models. Inferior survival outcomes were observed in ATB users compared to non-users (OS: 7.3 months, 95%CI 5.0 − 12.3 vs 13.7 months, 95%CI 12.2 − 47.3, p = 0.001; PFS: 5.1 months 95%CI 3.3 − 17.7 vs 8.3 months, 95%CI 7.1 − 47.3, p = 0.001) and also in corticosteroid users compared to non-users (OS: 8.4 months, 95%CI 6.6 − 10.0 vs 14.2 months, 95%CI 12.7 − 47.3, p < 0.001; PFS: 6.0 months 95%CI 4.6 − 7.9 vs 8.9 months, 95%CI 7.2 − 47.3, p = 0.004). In the Cox multivariate analysis, the concomitant drug score was a significant factor predicting both OS (HR = 1.32 [95% CI 1.03 − 1.68], p = 0.026) and PFS (HR = 1.23 [95% CI 1.01 − 1.51], p = 0.044). Our findings suggest detrimental impact of concomitant use of ATBs and corticosteroids on survival outcomes and the prognostic utility of the concomitant drug score in previously treated mUC patients receiving EV.
Understanding customer loyalty-aware recommender systems in E-commerce: an analytical perspective
Authors: Esmeli Ramazan , Can Ali Selcuk , Awad Aya , Bader-El-Den Mohamed 
Published: February 2025

Abstract
The selection of relevant variables is critical for providing personalized product and service recommendations on e-commerce businesses. However, the integration of e-loyalty-related features into recommender systems remains underexplored. This study aims to investigate the impact of incorporating e-loyalty indicators, such as purchase frequency and platform engagement, on the performance of recommender systems in the context of e-commerce businesses. Using three well-established recommender system models and four real-world datasets, we conducted computational experiments to assess performance improvements when e-loyalty features are incorporated. The results show that integrating e-loyalty-related features significantly enhances the performance of recommendation systems, with sequential deep neural networks outperforming other algorithms. Our study contributes to the literature by highlighting the value of leveraging customer loyalty data to enhance recommendation accuracy. Theoretical implications include underscoring the importance of using longitudinal user engagement data in recommender systems to move beyond static personalization toward adaptive, behavior-aware technologies. From a practical perspective, our findings suggest that incorporating e-loyalty features can improve recommendation accuracy, offering valuable insights for e-commerce businesses seeking to personalize their services. This research offers original contributions by focusing on the role of loyalty-driven features in improving recommender systems, an area that remains largely underexplored.
Mindfulness-based interventions for binge eating: an updated systematic review and meta-analysis
Authors: Liu Jianyi , Tynan Mara , Mouangue Alexandra , Martin Caroline , Manasse Stephanie , Godfrey Kathryn 
Published: February 2025

Abstract
Mindfulness-based interventions (MBIs) have gained popularity in recent years in treating binge eating. Previous reviews and meta-analyses have found that MBIs demonstrated medium-large to large effects in reducing binge eating. However, as the literature on this topic has been growing rapidly, an updated review on MBIs’ effectiveness is much needed. This study is a 10-year update of the Godfrey, Gallo, & Afari (2015) systematic review and meta-analysis of MBIs for binge eating. PubMED, PsycINFO, and Web of Science were searched using keywords including binge eating, overeating, objective bulimic episodes, acceptance and commitment therapy, dialectical behavior therapy, mindfulness, meditation, and mindful eating. Results indicate there has been a large increase in the number of studies testing MBIs for binge eating in the past 10 years with 54 studies meeting inclusion criteria, compared to 19 ten years ago. The majority of the studies yielded large and medium effect sizes. The random effects meta-analysis of between-group effect sizes yielded medium-large effects for MBIs versus non-psychological intervention controls at post-treatment (mean Hedge’s g = − 0.65) and follow-up (mean Hedge’s g = − 0.71), and negligible effects for MBIs versus active psychological controls at post-treatment (mean Hedge’s g = − 0.05) and follow-up (mean Hedge’s g = 0.13). Of all MBIs, DBT had the most studies with large effects. More studies examined MBIs that directly targeted binge eating had larger effects than studies with MBIs targeting other health outcomes (with binge eating as a secondary outcome). New studies included in the current review were internationally-conducted, focused more on participants with overweight or obesity, involved more self-help and technology-based components, and had more novel and innovative interventions components. Future MBIs research should conduct more RCTs comparing MBIs with other psychological interventions, conduct meta-analyses to examine the effectiveness of different types of MBIs and intervention targets, and extend follow-up periods.
Improved lower bound for estimating the number of defective items
Authors: Bshouty Nader H. 
Published: February 2025

Abstract
Consider a set of items, X, with a total of n items, among which a subset, denoted as

$$I\subseteq X$$

I
⊆
X

, consists of defective items. In the context of group testing, a test is conducted on a subset of items Q, where

$$Q \subset X$$

Q
⊂
X

. The result of this test is positive, yielding 1, if Q includes at least one defective item, that is if

$$Q \cap I \ne \emptyset $$

Q
∩
I
≠
∅

. It is negative, yielding 0, if no defective items are present in Q. We introduce a novel method for deriving lower bounds in the context of non-adaptive randomized group testing. For any given constant j, any non-adaptive randomized algorithm that, with probability at least 2/3, estimates the number of defective items |I| within a constant factor requires at least

$$\Omega \left( \dfrac{\log n}{\log \log {\mathop {\cdots }\limits ^{j}}\log n}\right) $$

Ω

log
n

log
log

⋯
j

log
n

tests. Our result almost matches the upper bound of

$$O(\log n)$$

O
(
log
n
)

and addresses the open problem posed by Damaschke and Sheikh Muhammad in (Combinatorial Optimization and Applications - 4th International Conference, COCOA 2010, pp 117–130, 2010; Discrete Math Alg Appl 2(3):291–312, 2010). Furthermore, it enhances the previously established lower bound of

$$\Omega (\log n/\log \log n)$$

Ω
(
log
n
/
log
log
n
)

by Ron and Tsur (ACM Trans Comput Theory 8(4): 15:1–15:19, 2016), and independently by Bshouty (30th International Symposium on Algorithms and Computation, ISAAC 2019, LIPIcs, vol 149, pp 2:1–2:9, 2019). For estimation within a non-constant factor

$$\alpha (n)$$

α
(
n
)

, we show: If a constant j exists such that

$$\alpha >{\log \log {\mathop {\cdots }\limits ^{j}}\log n}$$

α
>

log
log

⋯
j

log
n

, then any non-adaptive randomized algorithm that, with probability at least 2/3, estimates the number of defective items |I| to within a factor

$$\alpha $$

α

requires at least

$$\Omega \left( \dfrac{\log n}{\log \alpha }\right) .$$

Ω

log
n

log
α

.

In this case, the lower bound is tight.
The Berry Paradox
Authors: Tennant Neil 
Published: February 2025

Abstract
Berry’s Paradox, like Russell’s Paradox, is a ‘paradox’ in name only. It differs from genuine logico-semantic paradoxes such as the Liar Paradox, Grelling’s Paradox, the Postcard Paradox, Yablo’s Paradox, the Knower Paradox, Prior’s Intensional Paradoxes, and their ilk. These latter arise from semantic closure. Their genuine paradoxicality manifests itself as the non-normalizability of the formal proofs or disproofs associated with them. The Russell, the Berry, and the Burali-Forti ‘paradoxes’, by contrast, simply reveal the straightforward inconsistency of their respective existential claims—that the Russell set exists; that the Berry number exists; and that the ordinal of the well-ordering of all ordinals exists. The disproofs of these existential claims are in free logic and are in normal form. They show that certain complex singular terms do not—indeed, cannot—denote. All this counsels reconsideration of Ramsey’s famous division of paradoxes and contradictions into his Group A and Group B. The proof-theoretic criterion of genuine paradoxicality formally explicates an informal and occasionally confused notion. The criterion should be allowed to reform our intuitions about what makes for genuine paradoxicality, as opposed to straightforward (albeit surprising) inconsistency.