bluuebunny/crossref_metadata_2025_split huggingface dataset:
The survival of bike-sharing startups in China: an empirical analysis of the influencing factors
Authors: Zhou Yan , Park Sangmoon , Wang Qifeng , Zhang Justin Zuopeng , Behl Abhishek 
Published: March 2022

PurposeBike-sharing is popular worldwide, and it has led to a new development direction in green transportation. However, the collapse of many bike-sharing startups and residual social problems has brought about contradictions and challenges to the development of the industry. The purpose of this paper is to determine how internal factors affect the survival of bike-sharing startups.Design/methodology/approachThe authors used binary logit regression as the measurement model to conduct an empirical analysis based on 137 bike-sharing startups in China. The study focuses on using traditional theoretical evidence and considers the uniqueness of the industry to jointly explore the survival factors that influence the emerging business model of bike-sharing.FindingsThe results show that entrepreneurial team size and differentiation strategy positively influence survival. Founder-CEOs have a negative impact on survival. Founders' entrepreneurial experience and venture capital have no significant influence on survival.Originality/valueThe results verify the role of traditional survival factors in the new business model of sharing economy and fill the research gap on the survival strategy of startups. This study offers a unique perspective for researchers to better understand the sharing economy industry and provides practical guidance for entrepreneurs and investors to enter the market.
Measuring Internet banking service quality: an empirical evidence
Authors: Mir Rouf Ahmad , Rameez Raja , Tahir Nida 
Published: March 2022

PurposeThis study aims to empirically develop a reliable and valid instrument measuring the online service quality in the context of the banking sector in India.Design/methodology/approachThe methodological framework of this research comprises developing an instrument that is based on previous literature, qualitative and quantitative procedure. The study used the survey method and collected data via a well-structured questionnaire from a sample of active Internet banking users. The proposed instrument is identified by the data-reduction technique that is exploratory factor analysis (EFA), and validated through the confirmatory factor analysis (CFA).FindingsThe results confirmed that the digital banking service quality scale (DBSQual) contains 24 items in seven dimensions: (1) web architecture, (2) user friendliness, (3) efficiency of website, (4) reliability, (5) responsiveness, (6) security and (7) personalization. The relationship between digital banking service quality and e-customer satisfaction has also been found to be significant in this study.Research limitations/implicationsThe results of this study do not find general application for different banks operating in the same sector in India. More testing of DBSQual is required across various different contexts for validity augmentation. In addition, findings would be more reliable if the non-Indian context could be taken into consideration. Thus, such limitations open a window for future research.Practical implicationsThis study is quite fruitful for the banking organizations in measuring their online services, and enables them to implement their marketing and operational strategies more effectively and efficiently.Originality/valueThe contribution of this study is the development and validation of a new instrument that is DBSQual that contains seven determinants of customers' e-service quality perception, emphasis on measuring online service quality in the Indian banking sector. These determinants will offer banks a promising starting idea for establishing an effective quality management for their online businesses. They will be able to increase the opportunities by tapping themselves at a competitive edge.
Negotiating mental illness across the lay‐professional divide: Role play in peer work consultations
Authors: Kessing Malene Lue , Mik‐Meyer Nanna 
Published: March 2022

AbstractPatient involvement is a prominent policy aim in modern health care. Today, mental health services employ peer workers (PWs) who have personal experiences with mental illness. Based on 22 interviews with PWs and 26 audio recordings of real‐life consultations, we show how PWs talk about their personal experiences as professional qualifications. Furthermore, we demonstrate how in real‐life encounters, PWs and patients convert personal experiences into a professional approach through an interactionist role play that balance PWs role as former patients and current professionals. Our analysis shows that PWs combine the personal pronoun ‘I’ (stressing that it is personal) with the indefinite pronoun ‘one’ (referring to generalised patient experiences) when they recount illness experiences. This convey that PWs engage with mental illness as both a personal and professional topic. In addition, the analysis shows that PWs (and patients) use professional clues to manifest PWs’ positions as professionals. Overall, the article demonstrates that instead of focussing on authentic patient relationships, as previous research has done, it is beneficial to investigate peer work from a symbolic interactionist approach revealing how PWs and patients skilfully manoeuvre the contradictions embedded in the PWs’ dual role as former patients and current professionals.
International airports as agents of resilience
Authors: Horton Robert , Kiker Gregory A. , Trump Benjamin D. , Linkov Igor 
Published: March 2022

AbstractThe Dallas‐Fort Worth International Airport is used as an example of how traditional approaches of hardening isolated components of critical infrastructure against specific threats leaves critical assets exposed to significant, expensive, and unacceptable levels of cascading failure. Optimizing the entire airport supply chain requires the development of an interdisciplinary approach that incorporates the complexities of the airports' supply chain including numerous dependent, interdependent and independent relationships. Far greater return‐on‐investment will be yielded through resilience‐focused approaches that address the entire life cycle of disruptions including planning, absorption, recovery and adaptation.
Efficacy of cytapheresis for induction therapy and extra‐intestinal skin manifestations of ulcerative colitis
Authors: Shibuya Tomoyoshi , Nomura Osamu , Nomura Kei , Haraikawa Mayuko , Haga Keiichi , Ishikawa Dai , Osada Taro , Yamaji Ken , Ikeda Shigaku , Nagahara Akihito 
Published: March 2022

AbstractIntroductionIn recent years, the prevalence of inflammatory bowel diseases has been increasing in Japan due to the westernization of lifestyles. Many patients have been reported to have extra‐intestinal manifestations (EIMs) at least once. Skin lesions occur with a high degree of frequency among EIMs, with erythema nodosum (EN) and pyoderma gangrenosum (PG) the main complications. Cytapheresis is again attracting attention as a treatment with few side effects.MethodsWe investigated the therapeutic effect of cytapheresis on ulcerative colitis (UC) and cutaneous EIMs. Between 2008 and 2021, 240 patients with active UC had induction therapy by cytapheresis at our hospital.ResultsRemission and response rates were 50.0% and 67.5%, respectively. Apheresis was performed on seven patients with PG and five patients with EN with a good response. Serious adverse events were not observed.ConclusionThis retrospective assessment of efficacy showed that EN and PG responded favorably to cytapheresis.
The post‐COVID‐19 future of digital learning in higher education: Views from educators, students, and other professionals in six countries
Authors: Guppy Neil , Verpoorten Dominique , Boud David , Lin Lin , Tai Joanna , Bartolic Silvia 
Published: March 2022

AbstractPredictions about the post‐pandemic future of digital learning vary among higher education scholars. Some foresee dramatic, revolutionary change while others speculate that growth in educational technology will be buffeted both by modest expansion and unevenness. To this debate we contribute evidence from four groups across six countries on four continents: college and university educators (n = 281), students (n = 4243), senior administrators (n = 15), and instructional design specialists (n = 43). Our focus is on the future of digital learning after the pandemic‐induced pivot to emergency remote instruction. Using data from interviews and self‐administered questionnaires, our findings reveal a high degree of congruency between respondent groups, with most envisioning more blended/hybrid instruction post‐pandemic and some modest increases in fully online courses. Student opinion is more sceptical about future change than within the other groups. Among respondents in all groups there is little expectation for a full‐blown, revolutionary change in online or digital learning.
Practitioner notesWhat is already known about this topic

Digital learning has been growing in higher education, although a digital disconnect continues whereby the availability of educational technology exceeds its application to learning.
Expectations regarding technology‐mediated learning post‐COVID‐19 are mixed, hampering planning for the future.
Hesitancy about teaching or taking courses with some or full online components persists.
What this paper adds

A strong majority of respondents in higher education foresee the most growth in blended/hybrid forms of digital learning post‐COVID‐19.
A solid percentage, between about two‐thirds and three‐quarters of faculty and students, envision learners and instructors taking or teaching more fully online courses post‐pandemic.
A strong congruency exists between faculty, students, senior administrators, and instructional design professionals in their ranking of scenarios for the future of digital learning.
Implications for practice and/or policy

Educational technology in higher learning will not return to a pre‐COVID‐19 normality—if a pre‐COVID‐19 ‘normal’ could even be defined.
As post‐pandemic institutional planning unfolds, it is important to reflect experiences and incorporate insights of instructors, students, and instructional designers.
Successfully building on these insights, where more blended/hybrid learning is foreseen, requires a thoughtful integration of face‐to‐face learning and educational technology.
PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia‐like features
Authors: Fukui Katsuya , Nomura Miyuki , Kishimoto Kazuhiro , Tanuma Nobuhiro , Kurosawa Koreyuki , Kanazawa Kosuke , Kato Hiroyuki , Sato Tomoki , Miura Shinji , Miura Koh , Sato Ikuro , Tsuji Hiroyuki , Yamashita Yoji , Tamai Keiichi , Watanabe Toshio , Yasuda Jun , Tanaka Takuji , Satoh Kennichi , Furukawa Toru , Jingu Keiichi , Shima Hiroshi 
Published: March 2022

AbstractTo examine effects of PP6 gene (Ppp6c) deficiency on pancreatic tumor development, we developed pancreas‐specific, tamoxifen‐inducible Cre‐mediated KP (KRAS(G12D) plus Trp53‐deficient) mice (cKP mice) and crossed them with Ppp6cflox/flox mice. cKP mice with the homozygous Ppp6c deletion developed pancreatic tumors, became emaciated and required euthanasia within 150 days of mutation induction, phenotypes that were not seen in heterozygous or wild‐type (WT) mice. At 30 days, a comparative analysis of genes commonly altered in homozygous versus WT Ppp6c cKP mice revealed enhanced activation of Erk and NFκB pathways in homozygotes. By 80 days, the number and size of tumors and number of precancerous lesions had significantly increased in the pancreas of Ppp6c homozygous relative to heterozygous or WT cKP mice. Ppp6c−/− tumors were pathologically diagnosed as pancreatic ductal adenocarcinoma (PDAC) undergoing the epithelial–mesenchymal transition (EMT), and cancer cells had invaded surrounding tissues in three out of six cases. Transcriptome and metabolome analyses indicated an enhanced cancer‐specific glycolytic metabolism in Ppp6c‐deficient cKP mice and the increased expression of inflammatory cytokines. Individual Ppp6c−/− cKP mice showed weight loss, decreased skeletal muscle and adipose tissue, and increased circulating tumor necrosis factor (TNF)‐α and IL‐6 levels, suggestive of systemic inflammation. Overall, Ppp6c deficiency in the presence of K‐ras mutations and Trp53 gene deficiency promoted pancreatic tumorigenesis with generalized cachexia and early death. This study provided the first evidence that Ppp6c suppresses mouse pancreatic carcinogenesis and supports the use of Ppp6c‐deficient cKP mice as a model for developing treatments for cachexia associated with pancreatic cancer.
Reforms and inequalities in selective fields of higher education in France: Measuring the impacts using a dual approach
Authors: Jaoul‐Grammare Magali 
Published: March 2022

AbstractOne of the specificities of French higher education is that there is no single higher education system but two compartmentalised and hierarchical higher education systems comprising (1) universities and (2) grande école higher education institutions. Competing for a place in the latter requires that students have succeeded in classe préparatoire studies at the undergraduate level (an intensive foundation degree). While access to university is open to all students, access to classe préparatoire is very selective and remains the source of many inequalities. Thus, in 2018, only 7% of students studying in classe préparatoire programmes had a working‐class father, compared with 50% whose father was a manager, and less than 43% were women, 30% of whom were in the science stream (RERS, 2018). Numerous reforms have been implemented over the past thirty years to mitigate inequalities associated with gender, social and cultural status, as well as geographical location. This study analysed the impact of reforms on the evolution of inequalities. With focus on social and gender inequalities, I use a dual approach to analyse questions pertaining to access and the impact of reforms; specifically, (1) a cliometric approach, based on a quantitative historical analysis of long time series, and (2) a microeconomic approach that relies on individual series. I show that despite measures aimed at opening access to students of different gender and social backgrounds, the grandes écoles higher education institutions remain a relatively compartmentalised system that perpetuates the reproduction of social and gender inequalities.
Salivary gland involvement and oral health in patients with coeliac disease
Authors: Liu Jason , Lundemann Ann‐Kristine Juncker , Reibel Jesper , Pedersen Anne Marie Lynge 
Published: March 2022

AbstractCoeliac disease (CD) is a chronic immune‐mediated enteropathy triggered by ingestion of gluten. The aim of this study was to investigate if the salivary glands as a component of the mucosal immune system are involved in CD, leading to sialadenitis and salivary gland dysfunction and associated oral manifestations. Twenty patients with CD aged 49.2 (SD 15.5 years) and 20 age‐ and gender‐matched healthy controls underwent an interview regarding general and oral health, serological analysis, a clinical oral examination including bitewing radiographs, Candida smear, assessment of salivary mutans streptococci and lactobacilli levels, unstimulated and chewing‐stimulated whole and parotid saliva flow rates, analysis of secretory IgA, and a labial salivary gland biopsy. Xerostomia, mucosal lesions, dry/cracked lips and focal lymphocytic sialadenitis were more prevalent and extensive in patients with CD than in healthy controls. Moreover, the patients had less gingival inflammation and higher whole saliva flow rates than the healthy controls, but did not differ regarding dental health and levels of cariogenic bacteria and Candida. The major salivary gland function appears unaffected, contributing to maintenance of a balanced microbiota and oral health in CD patients. Xerostomia and labial dryness may be related to minor salivary gland inflammation and subsequent impaired mucosal lubrication.
Whole‐transcriptome sequencing identifies postzygotic ATP2A2 mutations in a patient misdiagnosed with herpes zoster, confirming the diagnosis of very late‐onset segmental Darier disease
Authors: Mohaghegh Fatemeh , Youssefian Leila , Galehdari Hamid , Tavakoli Narjes , Vahidnezhad Hassan , Uitto Jouni 
Published: March 2022

AbstractAn 82‐year‐old female patient presented with a recent onset of painful skin lesions in unilateral distribution on the abdominal area following the lines of Blaschko; the initial diagnosis of Varicella‐Zoster infection was made. However, because the individual lesions appeared as hyperkeratotic papules and were unresponsive to antiviral therapy, a skin biopsy was performed, which revealed hyperkeratosis, suprabasal acantholysis and dyskeratosis with corps ronds and grains, consistent with acantholytic dyskeratotic acanthoma. Since this entity has been associated with Darier disease, whole‐transcriptome sequencing by RNA‐Seq was performed on RNA isolated from a lesion and from adjacent normal appearing skin, and a recently developed bioinformatics pipeline that can identify both genomic sequence variants and the presence of any of 926 viruses was applied. Two pathogenic missense mutations in the ATP2A2 gene were identified in the lesional but not in normal appearing skin, and no evidence of Varicella‐Zoster infection was obtained. These findings confirm the diagnosis of segmental Darier disease due to postzygotic mutations in the ATP2A2 gene, and attest to the power of a novel single‐step application of RNA‐Seq in providing correct diagnosis in this rare genodermatosis.
Salivation in Parkinson's disease: A scoping review
Authors: Verhoeff Merel C. , Koutris Michail , Vries Ralph de , Berendse Henk W. , Dijk Karin D. van , Lobbezoo Frank 
Published: March 2022

AbstractObjectivesWe aimed to provide an overview of the available literature that includes both objective assessments (namely hypersalivation and hyposalivation) and the subjective experience (namely xerostomia and drooling) of salivary problems in patients with Parkinson's disease.BackgroundIn patients with Parkinson's disease, there may be complaints of salivary problems such as xerostomia or drooling. This can have consequences for their oral health and quality of life. To date, systematic reviews have focused on drooling only.Materials and methodsA literature search in 4 databases was performed up to 12 February 2021. Two researchers independently assessed studies for eligibility.ResultsIn total, 63 studies were included. The prevalence of self‐reported xerostomia ranged from 49% to 77%, and that of self‐reported drooling ranged from 5% to 80%. Ten articles reported a significantly lower mean salivary flow in patients with Parkinson's disease than in controls. None of the articles with both a control group and a patient group reported a significantly higher salivary flow in patients with Parkinson's disease. When questioned about subjective salivary problems, a significantly higher prevalence of both xerostomia (7 studies) and drooling (14 studies) was found in patients with Parkinson's disease than in controls. Patients with Parkinson's disease have a lower salivary flow rate and higher prevalence of both xerostomia and drooling than controls.ConclusionThe complexity of salivary problems present in patients with Parkinson's disease necessitates a multidisciplinary approach in order to avoid mutually counteracting treatments from different healthcare professionals.
Trajectories of muscle quantity, quality and function measurements in hospitalized older adults
Authors: Welch Carly , Greig Carolyn , Lewis Danielle , Majid Zeinab , Masud Tahir , Moorey Hannah , Pinkney Thomas , Stanley Benjamin , Jackson Thomas 
Published: March 2022

AimAcute sarcopenia is defined by the development of incident sarcopenia (low muscle quantity/quality and function) within 6 months of a stressor event. However, outcome measures for clinical trials have not been validated. This study aimed to characterize changes in muscle quantity, quality, strength, and physical function during and after hospitalization.MethodsPatients aged ≥70 years admitted for elective colorectal surgery, emergency abdominal surgery or acute infections were recruited from a single university hospital. Assessments were carried out at baseline, and within 7 ± 2 days and 13 ± 1 weeks postoperatively or post‐admission.ResultsA total of 79 participants (mean age 79 years, 39% female) were included. Physical function defined by the Patient‐Reported Outcome Measures Information System T‐score declined from baseline (42.3, 95% CI 40.2–44.3) to 7 days (36.6, 95% CI 34.5–38.8; P = 0.001), with improvement after 13 weeks (40.5, 95% CI 37.9–43.0). Changes in muscle quantity, quality and function measurements were overall heterogeneous, with few significant changes at the study population level. Change in rectus femoris echogenicity over 13 weeks correlated with changes in handgrip strength (r = 0.53; P < 0.001) and gait speed (r = 0.59; P = 0.003) over the same period.ConclusionsPatient‐Reported Outcome Measures Information System T‐score provides a sensitive measure of change in physical function in hospitalized older patients. However, changes in muscle quantity, quality and function measurements were heterogeneous, and not significant at the study population level. Further research should assess for factors that might be predictive of changes within individuals to enable stratified interventions. Geriatr Gerontol Int 2022; 22: 311–318.
Navigating white academe during crisis: The impact of COVID‐19 and racial violence on women of color professionals
Authors: Melaku Tsedale M. , Beeman Angie 
Published: March 2022

AbstractScholars have shown that women of color experience racial and gender aggressions in different workplaces but strategically in predominantly white institutions. This article explores how women of color professionals in academic institutions perceive their experiences during this time of multiple pandemics induced by COVID‐19 and racial violence. By examining research on women of color in academe and other white institutional spaces, we discuss how systemic racism is embedded within organizational practices that sustain racial inequality. Drawing on data from a qualitative online survey of women of color in academe (n = 25), our theoretically grounded research employs Black feminist thought as a methodological practice to examine how COVID‐19 and racial violence have impacted women of color through the continued perpetuation of racial and gender inequities. The findings provide important insights on how institutional responses to public discourses about racism can influence the experiences of women of color and their career trajectories.