bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of SNP g.10428C>T of Stearoyl-CoA Desaturase gene related to meat quality in Bali cattle using PCR-RFLP method
Authors: Karimah S. N. , Noor R. R. , Jakaria J. 
Published: March 2022

The objectives of this research was to analyze the polymorphisms of SNP g.10428C>T in the SCD gene using PCR-RFLP and its association with meat charactheristics in Bali cattle. The number of 52 Bali cattle from BPTU-HTP Denpasar were used in this study and which were compared to Belgianblue (n=30), Limousine (n=14), Peranakan Ongole (PO) (n=30) and Wagyu (n=7). The polymorphism of the SCD gene was characterized by the use of the PCR-RFLP technique with HinfI enzyme restriction. The characteristics of the meat quality in Bali cattle were estimated using ultrasound imaging method. Genotyphic and allelic frequencies, heterozygosity values, and the Hardy-Weinberg equilibrium have been calculated using PopGen 1.32. The association between genotypes of SNP g.10428C>T SCD gene and meat quality characteristics was calculated using t-test. The results showed that homozygous genotypes (CC and TT) and heterozygous genotypes (CT) of the SCD|HinfI gene with C (0.26) and T (0.74) allele frequencies were and in Bali cattle. The CC genotype was found in Belgian-blue, Limousine, PO, and Wagyu cattle with the allele C frequency of 1.00. The observed heterozygosity (Ho=0.44) higher than expected heterozygosity (He=0.39) showed high diversity in Bali cattle. Genotypes of SNP g.10428C>T SCD gene were associated with backfat thickness, marbling score, and percentage of intramuscular fat. Thus the SNPs g.10428C>T have potential as marker-assisted selection candidates for Bali cattle.
Application of green tea waste with fibrolytic enzyme and phytase on layer performance and egg quality
Authors: Chumkam S. , Jintasataporn O. , Triwutanon S. 
Published: March 2022

This study aimed to investigate the effect of green tea waste, fibrolytic enzymes (xylanase and cellulase) and phytase supplementation in layer diets on performance and egg quality. The experiment was assigned in a 2×3 factorial arrangement by completely randomized design. Factor A consisted of two types of diets: a) a basal diet without any green tea waste and b) a basal diet with 1% of green tea waste. Factor B consisted of three levels of enzymes: a) level 0X, no enzyme supplementation; b) level 1X, a combination of fibrolytic enzymes, 24,000 FAXU xylanase and 100 ECU cellulase, and 1,000 FTU phytase; and c) level 2X, combination of fibrolytic enzymes, 48,000 FAXU xylanase and 200 ECU cellulase, and 2,000 FTU phytase. One hundred and ninety- two Roman Brown hens, aged 52 weeks, were randomly distributed to six groups and four replications. Layer hens were fed commercial diets with green tea waste and fibrolytic enzymes added on top as assigned in the treatment. The results showed that green tea waste significantly increased (p<0.05) egg production, egg mass, feed conversion, and Haugh unit. In addition, green tea waste tended to affect (p=0.07) TBAs value. Furthermore, the enzyme level significantly decreased (p<0.05) feed intake and TBAs value. In conclusion, the supplementation of 1% of green tea waste and 2X enzymes can improve feed conversion and the antioxidative property of eggs.
Pricing of livestock products in Indonesian modern food retailers during covid-19 pandemic
Authors: Pambudy R. , Adhi A. K. , Herawati H. , Harianto H. 
Published: March 2022

The role of modern markets is increasing in the food system in Indonesia, mainly as a result of technological and institutional advances. Indonesian households' food consumption still depends on staple food. The share of household expenditure on meat, eggs, and milk was only 12 percent. The purpose of the study was to analyze the pricing of livestock products in retail level in the modern market. The data used in this study is daily price data for beef, eggs, and chicken at wholesale and retail levels published through the National Strategic Food Price Information Center (PIHPSN) from January 2020 to December 2020. This study employed a quantitative method, through the formulation of an econometric model, and applied the 3SLS method to estimate the model. The results show that traders face an increasing price risk following the Covid-19 pandemic. The retailers enforce price stabilization at the consumer level when prices at the wholesaler level fluctuate. However, the study did not find the practice of price averaging between commodities at the retailers level. The results of this study are useful for policy formulations aimed at stabilizing food prices.
Swimming attenuates tumor growth in CT-26 tumor-bearing mice and suppresses angiogenesis by mediating the HIF-1α/VEGFA pathway
Authors: Li Jiapeng , Liu Liya , Cheng Ying , Xie Qiurong , Wu Meizhu , Chen Xiaoping , Li Zuanfang , Chen Haichun , Peng Jun , Shen Aling 
Published: March 2022

Abstract
Low physical activity correlates with increased cancer risk in various cancer types, including colorectal cancer (CRC). However, the ways in which swimming can benefit CRC remain largely unknown. In this study, mice bearing tumors derived from CT-26 cells were randomly divided into the control and swimming groups. Mice in the swimming group were subjected to physical training (swimming) for 3 weeks. Compared with the control group, swimming clearly attenuated tumor volume and tumor weight in CT-26 tumor-bearing mice. RNA sequencing (RNA-seq) identified 715 upregulated and 629 downregulated transcripts (including VEGFA) in tumor tissues of mice in the swimming group. KEGG pathway analysis based on differentially expressed transcripts identified multiple enriched signaling pathways, including angiogenesis, hypoxia, and vascular endothelial growth factor (VEGF) pathways. Consistently, IHC analysis revealed that swimming significantly downregulated CD31, HIF-1α, VEGFA, and VEGFR2 protein expression in tumor tissues. In conclusion, swimming significantly attenuates tumor growth in CT-26 tumor-bearing mice by inhibiting tumor angiogenesis via the suppression of the HIF-1α/VEGFA pathway.
Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook
Authors: Liu Yang , Hao Huiqin , Hou Tiezheng 
Published: March 2022

Abstract
The concanavalin A (Con A)-induced liver injury mouse model is a typical animal model focusing on T cell-dependent hepatic damage in the field of autoimmune hepatitis (AIH). However, the underlying mechanism of hepatic dysfunction due to cell activation or signaling pathways triggered by Con A has not been fully clarified. Therefore, the controversy on this model remains in the academic community. In this article, we first summarized the merit and demerit of this contentious model from the perspectives of cell dysfunction, microcirculation disturbance, involved signaling pathways, as well as the properties of Con A. Then, we summed up the scientific implications of the model in elucidating the pathogenesis of AIH, and the shortcomings of this model were also summarized to elucidate the pathogenesis and application prospect of this classical liver injury mouse model in the study of AIH.
Regulation of miR-30b in cancer development, apoptosis, and drug resistance
Authors: Fu Zhen-Jie , Chen Yan , Xu Yu-Qin , Lin Mei-Ai , Wen Hang , Chen Yi-Tao , Pan Pei-Lei 
Published: March 2022

Abstract
miR-30b, which is encoded by the gene located on chromosome 8q24.22, plays an important role in a variety of diseases. In most types of tumors, miR-30b significantly inhibits the proliferation, migration, and invasion of cancer cells through the regulation of target genes. Moreover, miR-30b can inhibit the PI3K/AKT signaling pathway through the regulation of EGFR, AKT, Derlin-1, GNA13, SIX1, and other target genes, thus inhibiting the EMT process of tumor cells and promoting apoptosis. In addition, miR-30 plays a significant role in alleviating drug resistance in tumor cells. Although the use of miR-30b as a clinical diagnostic indicator or anticancer drug is still facing great difficulties in the short term, with the deepening of research, the potential application of miR-30b is emerging.
Implementation of multilingual mother tongue education in Cambodian public schools for indigenous ethnic minority students
Authors: Wright Wayne E. , Boun Sovicheth , Chan Virak 
Published: March 2022

Abstract
In this qualitative interpretive policy analysis case study, we examine the Cambodian government’s adoption and expansion of a Multilingual Education (MLE) program for speakers of different indigenous ethnic minority languages across five Northeastern provinces. Data include MLE policy documents and curriculum, observations in MLE schools, and interviews and focus groups with NGO staff, government officials, MLE Core Trainers, local MLE teachers, and school board members. We also analyze the nature of Khmer and indigenous language use and the nature of teaching and learning in the MLE schools and classrooms. Findings reveal significant success in establishing new schools and programs, expanding access to nearly 5,000 indigenous students, but also identify a number of challenges related to the governments’ capacity to further develop and expand MLE, with continual reliance on NGOs for technical and other support. Analyses of classroom observation data provide evidence of fidelity to the MLE model and curriculum, effective teaching and learning, and highly engaged teachers and students.
A topological correspondence between partial actions of groups and inverse semigroup actions
Authors: Martínez Luis , Pinedo Héctor , Uzcátegui Carlos 
Published: March 2022

Abstract
We present some generalizations of the well-known correspondence, found by Exel, between partial actions of a group G on a set X and semigroup homomorphism of

𝒮
⁡

(
G
)

{\operatorname{\mathcal{S}}(G)}

on the semigroup

I
⁢

(
X
)

{I(X)}

of partial bijections of X, with

𝒮
⁡

(
G
)

{\operatorname{\mathcal{S}}(G)}

being an inverse monoid introduced by Exel. We show that any unital premorphism

θ
:

G
→
S

{\theta:G\to S}

, where S is an inverse monoid, can be extended to a semigroup homomorphism

θ
*

:

T
→
S

{\theta^{*}:T\to S}

for any inverse semigroup T with

𝒮
⁡

(
G
)

⊆
T
⊆

P
*

⁢

(
G
)

×
G

{\operatorname{\mathcal{S}}(G)\subseteq T\subseteq P^{*}(G)\times G}

, with

P
*

⁢

(
G
)

{P^{*}(G)}

being the semigroup of non-empty subsets of G, and such that

E
⁢

(
S
)

{E(S)}

satisfies some lattice-theoretical condition.
We also consider a topological version of this result. We present a minimal Hausdorff inverse semigroup topology on

Γ
⁢

(
X
)

{\Gamma(X)}

, the inverse semigroup of partial homeomorphisms between open subsets of a locally compact Hausdorff space X.
Thermal Analysis of Fibers
Authors: Qian Baojun , Wu Zongquan , Yang Pingyu , Qin Jian 
Published: March 2022

Abstract
Conducting thermal analysis of fibers in the swollen state possesses certain characteristics and advantages. The thermograms including both TMA and DSC of 12 acrylic fiber samples of different composition and mode of formation are given in this part of the paper. The lowering of the transition temperature as a depression of the melting points according to the theory of Flory is tested. The DSC thermograms of a commercial acrylic fiber sample are separated into its constituent peaks and the bond energy of the four regions is calculated. Finally the relation of the magnitudes of the different peak of a PAC
Abbreviation of polyacrylonitrile copolymer.
) fiber sample is sought and the effects of annealing and hot stretching of acrylic fibers on its texture are demonstrated.
Gel-Permeation Chromatography as a Tool for the Real-Time-Estimation of the Chain length Distribution in a Polymerization Reactor
Authors: Papadopoulou S. 
Published: March 2022

Abstract
The knowledge of the chain length distribution (CLD) during the operation in a polymerization reactor is necessary in order to control polymer quality. Model-based measurement methods (Kalman filter) provide the possibility of reconstructing on-line not directly accessible process states from easily available measurements. However, the presence of model inaccuracies or disturbances influencing primarily the CLD demand additional measurement information about CLD.
An extended Kalman filter composed of two decoupled filters and considering Gel-Permeation chromatographic, (GPC), measurements for the continuous estimation of the CLD in the case of free radical polymerization of styrene is discussed. Although the existence of a time delay, due to the GPC analysis, the consideration of this measurement in the filter algorithm produces the local observability of the states characterizing the CLD, allows continuous access to the CLD and its characteristic values and provides a periodical adaption of the CLD to the reality.
Spinnability and Dyeability for Copolymer/Nano-SiO2 Fiber of Glycol and 1,2-Propanediol with PTA
Authors: Wu J. , Chen Y. , Li Z. , Li S. 
Published: March 2022

Abstract
In the use of corn raw materials to produce glycol (corn-EG) and 1,2-propanediol (PDO), the output of PDO is more than that of corn-EG and the latter also contains some PDO. In order to produce high-performance polyester fibers by low-cost corn-EG instead of petroleum-EG, the paper initially seeks for the highest percentage of PDO that can be added in the conventional copolymerization of corn-EG/PDO/nano-SiO2 and terephthalic acid (PTA). The experiment shows that as the content of PDO in copolyester exceeds 12 %, the POY breaking strength quickly decreases. The DTY of copolyester fiber with 12% PDO and 0.1% nano-SiO2 can be dyed in the condition of atmospheric pressure and boiling water.
Gas Assisted Injection Molding of an Industrial Part: 3D Simulation Provides Virtual Molding Trials
Authors: Polynkin A. , Pittman J. F. T. , Sienz J. 
Published: March 2022

Abstract
Techniques developed for three-dimensional simulation of gas assisted injection molding of thermoplastics are here extended to a complex industrial application, a car door handle, providing uniquely detailed insights into the molding process. Handling of the three stages of the process – plastic filling, and primary and secondary gas penetration – is described in terms of the boundary and initial conditions applied. Predictions for plastic filling patterns are compared successfully with molding results, and provide detailed forewarning of potential problems due to weld surfaces and air-traps. Particular emphasis is placed on accurate modeling of secondary gas penetration, which is also validated against practical results. A further novel feature is the export of an STL model of the gas core, providing a CAD model of the finished molding for subsequent in-service analysis.
Facility-based stillbirth surveillance review and response: an initiative towards reducing stillbirths in a tertiary care hospital of India
Authors: Sharma Bharti , Aggarwal Neelam , Suri Vanita , Siwatch Sujata , Kakkar Nandita , Venkataseshan Sundaram 
Published: March 2022

Abstract

Objectives
India has the highest number of stillbirths in the world in 2019, with an estimated stillbirth rate of 13.9 per 1,000 births. Towards better identification and documentation, a stillbirth surveillance pilot was initiated with the World Health Organization Southeast Asia collaboration in Northern India in 2014. This study aimed to assess whether stillbirth surveillance is feasible and whether this approach provides sufficient information to develop strategies for prevention.

Methods
This study followed the framework provided in “WHO Making Every Baby Count” in which mortality audit is conducted in six steps; (1) identifying cases; (2) collecting information; (3) analysis; (4) recommending solutions; (5) implementing solutions; and (6) evaluation.

Results
A total of 5,284 births were examined between December 2018 and November 2019; 266 stillbirths were identified, giving a stillbirth rate of 50.6 per 1,000 births in a tertiary care referral hospital of northern India. Out of 266 stillbirths, 223 cases were reviewed and recommendations were formulated to strengthen obstetric triage, implementing fetal growth charts, strengthen the existing referral system and improve the communication skills of health care providers for better compliance with clinical practice guidelines.

Conclusions
Conducting stillbirth surveillance review and the response of cases in low-middle income countries setting is feasible. As countries progress towards ending preventable mortality, this has the potential to serve as a key process in improving evidence-based and context-specific planning and preventive strategies towards improving the quality of care.
High efficiency and large optical anisotropy in the high-order nonlinear processes of 2D perovskite nanosheets
Authors: Chen Zehong , Shi Zhonghong , Zhang Wenbo , Li Zixian , Zhou Zhang-Kai 
Published: March 2022

Abstract
Nonlinear nanophotonic devices have brought about great advances in the fields of nano-optics, quantum science, biomedical engineering, etc. However, in order to push these nanophotonic devices out of laboratory, it is still highly necessary to improve their efficiency. Since obtaining novel nanomaterials with large nonlinearity is of crucial importance for improving the efficiency of nonlinear nanodevices, we propose the two-dimensional (2D) perovskites. Different from most previous studies which focused on the 2D perovskites in large scale (such as the bulk materials or the thick flakes), herein we studied the 2D perovskites nanosheets with thickness of ∼50 nm. The high-order nonlinear processes including multi-photon photoluminescence and third-harmonic generation (THG) have been systematically investigated, and it is found the THG process can have a high conversion efficiency up to ∼8 × 10−6. Also, it is observed that the nonlinear responses of 2D perovskites have large optical anisotropy, i.e., the polarization ratio for the incident polarization dependence of nonlinear response can be as high as ∼0.99, which is an impressive record in the perovskite systems. Our findings reveal the properties of high efficiency and huge optical anisotropy in the nonlinear processes of 2D perovskite nanosheets, shedding light on the design of advanced integrated nonlinear nanodevices in future.
Inverse-designed waveguide-based biosensor for high-sensitivity, single-frequency detection of biomolecules
Authors: Chung Haejun , Park Junjeong , Boriskina Svetlana V. 
Published: March 2022

Abstract
Integrated silicon photonic waveguide biosensors have shown great potential for detecting bio-molecules because they enable efficient device functionalization via a well-developed surface chemistry, as well as simple scalable manufacturing, which makes them particularly suitable for low-cost point-of-care diagnostic. The on-chip integrated biosensors can be broadly classified into two types: (i) high-quality factor resonator sensors and (ii) interferometric sensors relying on non-resonant optical elements such as e.g. integrated waveguides. The former type usually requires a broadband or a tunable light source as well as complicated signal post-processing to measure a shift of the resonance frequency, while the latter exhibits a relatively low sensitivity due to the lack of efficient light recycling and phase accumulation mechanism in low quality factor elements. Additionally, high quality factor resonant photonic structures can be very sensitive to the presence of other non-target molecules in the water solution, causing sensor vulnerability to any noise. In this work, we combine a computational “inverse design” technique and a recently introduced high-contrast probe cleavage detection (HCCD) technique to design and optimize waveguide-based biosensors that demonstrate high sensitivity to the target molecule while being less sensitive to noise. The proposed biosensors only require a single frequency (or narrow-band) source and an intensity detector, which greatly simplifies the detection system, making it suitable for point-of-care applications. The optimal integrated sensor design that we demonstrate shows 98.3% transmission for the positive (target detected, probes cleaved) state and 4.9% transmission for the negative (probes are still attached) state at 1550 nm wavelength. The signal intensity contrast (20.06-fold transmission increase) shown in this work is much greater than the shift of the resonance frequency (less than 1% wavelength shift) observed in conventional ring-resonator-based biosensors. The new design may pave the way for realizing a single-frequency highly sensitive and selective optical biosensor system with a small physical footprint and a simple optical readout on a silicon chip.
Consensus statement for treatment protocols in pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Authors: Sgarbura Olivia , Eveno Clarisse , Alyami Mohammad , Bakrin Naoual , Guiral Delia Cortes , Ceelen Wim , Delgadillo Xavier , Dellinger Thanh , Di Giorgio Andrea , Kefleyesus Amaniel , Khomiakov Vladimir , Mortensen Michael Bau , Murphy Jamie , Pocard Marc , Reymond Marc , Robella Manuela , Rovers Koen P. , So Jimmy , Somashekhar S.P. , Tempfer Clemens , Van der Speeten Kurt , Villeneuve Laurent , Yong Wei Peng , Hübner Martin 
Published: March 2022

Abstract

Objectives
Safe implementation and thorough evaluation of new treatments require prospective data monitoring and standardization of treatments. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a promising alternative for the treatment of patients with peritoneal disease with an increasing number of suggested drug regimens. The aim was to reach expert consensus on current PIPAC treatment protocols and to define the most important research topics.

Methods
The expert panel included the most active PIPAC centers, organizers of PIPAC courses and principal investigators of prospective studies on PIPAC. A comprehensive literature review served as base for a two-day hybrid consensus meeting which was accompanied by a modified three-round Delphi process. Consensus bar was set at 70% for combined (strong and weak) positive or negative votes according to GRADE. Research questions were prioritized from 0 to 10 (highest importance).

Results
Twenty-two out of 26 invited experts completed the entire consensus process. Consensus was reached for 10/10 final questions. The combination of doxorubicin (2.1 mg/m2) and cisplatin (10.5 mg/m2) was endorsed by 20/22 experts (90.9%). 16/22 (72.7%) supported oxaliplatin at 120 with potential reduction to 90 mg/m2 (frail patients), and 77.2% suggested PIPAC-Ox in combination with 5-FU. Mitomycin-C and Nab-paclitaxel were favoured as alternative regimens. The most important research questions concerned PIPAC conditions (n=3), standard (n=4) and alternative regimens (n=5) and efficacy of PIPAC treatment (n=2); 8/14 were given a priority of ≥8/10.

Conclusions
The current consensus should help to limit heterogeneity of treatment protocols but underlines the utmost importance of further research.