bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable Intensification and Large-scale Operation of Cultivated Land Use at the Farmers' Scale: A Case Study of Shandong Province, China
Authors: Li Li , Lyu Xiao , Zhang Anlu , Niu Shandong , Peng Wenlong 
Published: July 2022

Abstract
Sustainable intensification of cultivated land use (SICLU) and large-scale operations (LSO) are widely recognized to improve agricultural performance. However, the current literature is ambiguous in defining sustainable intensification (SI), incomprehensive in structuring SI indicators, and very limited in discussing their impacting mechanism. Self-efficacy is an important psychological factor that affects farmers’ land-use behavior. Based on conceptualizing the connotation and extension of SICLU, we designed an index framework (including subjective and objective indicators) to assess SICLU. Then, by evolving the input and output of agricultural materials, a demonstration was carried out with the example of SICLU and LSO in Shandong Province, China. Logistic, OLS, and BRT models were used to quantify the possible degree and dynamic curve between SICLU indicators (such as policy cognition, labor availability, grain transaction turnover, machinery input, and irrigation input) and LSO.
Variations in the TAS2R38 Gene Among College Students in Hubei
Authors: Wang Xiaojun , Wang Lin , Xia Mengwei , Teng Feng , Chen Xuejiao , Huang Rufeng , Zhou Jiahao , Xiao Juan , Zhai Lihong 
Published: July 2022

Abstract
Background: The bitter taste receptor gene TAS2R38 is a member of the human TAS2R gene family. Polymorphisms in TAS2R38 affect the ability to taste the bitterness of phenylthiourea (PTC) compounds, thus affecting an individual’s food preference and health status. Methods: We investigated polymorphisms in the TAS2R38 gene and the sensitivity to PTC bitterness among healthy Chinese college students in Hubei province. The association of TAS2R38 polymorphisms and PTC sensitivity with body mass index (BMI), food preference, and health status was also analyzed. A total of 320 healthy college students were enrolled (male: 133, female: 187; aged 18–23 years). The threshold value method was used to measure the perception of PTC bitterness, and a questionnaire was used to analyze dietary preferences and health status. Polymerase chain reaction (PCR) was used to analyze polymorphisms at three common TAS2R38 loci (rs713598, rs1726866, and rs10246939). Results: In our study population, 65.00% of individuals had medium sensitivity to the bitterness of PTC; in contrast, 20.94% were highly sensitive to PTC bitterness, and 14.06% were not sensitive. For the TAS2R38 gene, the PAV/PAV and PAV/AAI diplotypes were the most common (42.19% and 40.63%, respectively), followed by the homozygous AVI/AVI (8.75%) and PAV/AVI (5.00%) diplotypes. Conclusions: There was a significant correlation between the sensitivity to PTC bitterness and sex, but there was no correlation between the common diplotypes of TAS2R38 and gender. Polymorphisms in the TAS2R38 gene were associated with the preference for tea, but not with one’s native place, BMI, health status, or other dietary preferences. There was no significant correlation between the perception of PTC bitterness and one’s native place, BMI, dietary preference, or health status. We hope to find out the relationship between PTC sensitivity and TAS2R38 gene polymorphisms and dietary preference and health status of Chinese population through this study, providing relevant guidance and suggestions for dietary guidance and prevention of some chronic diseases in Chinese population.
Contraceptive Experiences of Women of Procreation Age Who Attended Two Health Centers in the City of Abidjan (Cote D'ivoire)
Authors: Essis Esme Marie Laure , Koffi Kouassi Benjamin , Manouan N'guetta Mathilde , Coulibaly-Koné Soltié Aminata , Iba Bamba , Kpebo Djoukou Olga Denise , Konan Loukou Leandres , Aka Joseph , Nola Prata 
Published: July 2022

Abstract
Introduction: Maternal mortality, which is estimated at 614 deaths per 100,000 births in Côte d'Ivoire, is associated with a low national contraceptive prevalence rate of 13.9%. In this study, we are interested in the contraceptive experiences of women who attend health centers to estimate their rate of contraceptive use and to assess the factors involved in the use of modern contraceptive methods among women of childbearing age who are exposed to the risk of pregnancy. Method: A descriptive cross-sectional study was conducted among 423 women, who attended two health centers in Abidjan. A bivariate analysis identified factors associated with contraceptive use by these women. A descriptive analysis determined the means for the quantitative variables and the frequencies and percentages of qualitative variables. Interpretation of results was based on significance (α=5%, 95% CI).Results: Contraceptive prevalence was 37%. There was a significant relationship between contraceptive use and the socio-demographic and reproductive characteristics of women (p < 0.001).Conclusion: Women who were aged over 35 years, uneducated, primary school graduates, housewives, unemployed, in the informal sector, Muslims, nulliparous, and lacking information and decision-making power were less likely to use modern contraceptive methods. They are the target population for strategic interventions to improve contraceptive prevalence.
Prenatal diagnosis of an adrenal mature teratoma mimicking a neuroblastoma
Authors: Garcia Camille , Fusi Giulia , Gambart Marion , Sartor Agnès , Gomez-Mascard Anne , Abbo Olivier 
Published: July 2022

Abstract
Aim of the study: To present our experience with an adrenal antenatal mass firstly diagnosed as a left adrenal neuroblastoma that turned out to be a mature teratoma after anatomopathology. Case description: We present the case of an infant with an antenatal diagnosis of a left adrenal cystic image on the 22nd week of amenorrhea ultrasound. The fetal MRI showed a 20 x 13 mm non-calcified cystic formation of the left adrenal gland, compatible with a neuroblastoma.At birth, the diagnosis has been confirmed by an ultrasound that showed an anechogenic image of the left adrenal gland of 17 x 12 mm, with thin walls.Besides, in the 9 months interval between birth and the last CT scan, the image had minimally diminished in size. Then it stabilized at about 2 cm. The workup was otherwise normal. The infant was closely monitored during his first year and in the absence of significant regression of the adrenal mass, we decided to perform a left laparoscopical adrenalectomy. Unexpectedly, the anatomopathologist results showed a mature cystic adrenal teratoma. Conclusions: An adrenal mass diagnosed antenatally is generally a haemorrhage or a neuroblastoma. Only two other case of unexpected adrenal teratoma in infants are described in literature. Adrenal teratomas are very rare and those diagnosed antenatally even more. At present, we have no clinical, biological, or radiological evidence to suspect them before surgical removal.
Trans-ancestry meta-analysis improves performance of genetic scores for multiple adiposity-related traits in East Asian populations
Authors: Walters Robin , Fairhurst-Hunter Zammy , Lin Kuang , Millwood Iona , Pozarickij Alfred , Chen Tzu-Ting , Torres Jason M. , Luan Jian'an , Kartsonaki Christiana , Gan Wei , Mahajan Anubha , Du Huaidong , Sohoni Rajani , Guo Yu , Sansome Sam , Yang Ling , Yu Canqing , Chen Yiping , Lv Jun , Hemani Gibran , Koido Masaru , Kamatani Yoichiro , Spracklen Cassandra , Gordon-Larsen Penny , Koprulu Mine , Meng Xiangrui , Kuchenbaecker Karoline , Fatumo Segun , Bhatta Laxmi , Brumpton Ben , Alegre-Diaz Jesus , Kuri-Morales Pablo , Tapia-Conyer Roberto , Graham Sarah , Willer Cristen , Neville Matthew , Karpe Fredrik , Graff Mariaelisa , North Kari , Loos Ruth , Haiman Christopher , Peters Ulrike , Buyske Steven , Gignoux Christopher , Wojcik Genevieve , Lin Yen-Feng , Li Liming , McCarthy Mark , Chen Zhengming , Holmes Michael 
Published: July 2022

Abstract
Genome-wide association studies (GWAS) in predominately European-ancestry (EUR) populations have identified numerous genetic variants associated with adiposity-related traits. An emerging challenge is the limited transferability of genetic scores constructed based on GWAS results from one ancestry for trait prediction in other ancestries. We performed trans-ancestry meta-analysis (TAMA) for eight adiposity-related traits using genetic data from 96,124 East Asian (EAS) and 443,359 EUR individuals. We identified >1400 genomic regions significantly associated with one or more traits. Despite EAS comprising only ~20% of the study population, genetic scores constructed from the trans-ancestry (TA) results accounted for between 30% and 79% more variation in the adiposity traits in EAS compared with scores derived from the EUR GWAS alone. Furthermore, TA scores also modestly improved variance explained in African/African American, Hispanic and South Asian populations. Our findings highlight the utility of TAMA for increasing variance explained by genetic scores across populations of different ancestries.
Usability and perceptions of a Telementoring Program for young physicians in rural settings of Peru: A mixed method study
Authors: Rojas-Mezarina Leonardo , Escobar-Agreda Stefan , Chahuara-Rojas Max , Silva-Valencia Javier , Herrera Héctor Espinoza , Reátegui-Rivera C. Mahony , Moscoso Miguel G. , Quispe-Gamarra Juan , Ronceros Gerardo 
Published: July 2022

Abstract
Background: Telementoring seems to be a promising strategy to deliver training and counselling to physicians in remote areas. In Peru, early graduated physicians must work for the Rural and Urban-Edge Health Service Program where they face important training needs. The aim of this study was to describe the usage of a Telementoring program for rural physicians and evaluate the aspects related to the perceptions of acceptability and usability.Methods: Mixed methods study on recently graduated physicians who work in rural areas and participate in the Telementoring program. The program used a mobile application to connect these young doctors with specialized mentors to answer queries about real-life problems raised by working in a rural area. We summarize administrative data to assess participant characteristics and their participation in the program. Additionally, we conducted in-depth interviews to explore the perceived usability, ease of use, and reason for non-use of the Telementoring program.Results: Of 74 physicians (mean age 25, 51.4% women) enrolled, 12 (16.2%) actively used the program and performed a total of 27 queries, which received response in an average time of 5.4 ± 6.3 hours. In the interviews, the main reasons for non-use were connectivity issues, feelings of shame, and self-efficacy. For those who used the Telementoring program they referred it was easy to use and solve their inquiries timely. Conclusions:The implementation of a Telementoring program sought to provide guidance to recently graduated physicians working in rural areas. Low use rates show that administrative and process-related deficiencies in the program implementation need to be improved.
Creation and Validation of an Algorithm Predicting Recurrence of Atrial Fibrillation Following Pulmonary Vein Isolation Utilizing Ensemble Modeling Techniques
Authors: Horde Gaither , Ayyala Deepak Nag , Maddux Paul , Gopal Aaron , White William , Berman Adam E 
Published: July 2022

Abstract
Catheter ablation (CA) of atrial fibrillation (AF) represents a mainstay of treatment of this prevalent arrhythmia. Clinical trials investigating the efficacy of CA may poorly represent real-world patient populations. However, many real-world data sets possess missing data, which may impede their applicability in research. We sought to use ensemble modeling to address missing data and develop a model to estimate the probability of AF recurrence following CA. We retrospectively analyzed clinical variables in 476 patients who underwent an initial CA of AF. Univariate and multivariate logistic regression was performed to determine those variables predictive of AF recurrence. A multivariate logistic model was created to estimate the probability of AF recurrence after CA. Missing data was addressed using ensemble modeling and variable selection was performed using the aggregate of multiple models. After analysis, six variables remained in the model. Predictive modeling was performed using these variables for 1000 randomly partitioned datasets (80% training, 20% testing) and 1000 random imputations for each partitioned dataset. The model predicted AF recurrence with an accuracy of 74.34 ± 3.99%. Application of this model to patients undergoing CA may help identify those at risk of AF recurrence.
Frequency Specific Alterations of the Degree Centrality in Patients with Acute Basal Ganglia Ischemic Stroke: A Resting-State fMRI Study
Authors: Chen Hao , Zhan Linlin , Li Qianqian , Meng Chaoguo , Quan Xuemei , Chen Xiaoling , Hao Zeqi , Li Jing , Gao Yanyan , Li Huayun , Jia Xize , Li Mengting , Liang Zhijian 
Published: July 2022

Abstract
This study intends to investigate the frequency specific of brain oscillation activity in patients with acute basal ganglia ischemic stroke (BGIS) by using degree centrality (DC) method. Here, 34 acute BGIS patients and 43 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning to investigate abnormal neural activity using the DC method within three frequency bands: conventional band (0.01-0.08Hz), slow‑4 band (0.027-0.073Hz), slow‑5 band (0.01-0.027Hz). Moreover, correlation between abnormal DC values and clinical indicators was performed. In conventional band, compare to HCs, BGIS patients exhibited increased DC values in the right superior temporal gyrus, right superior frontal gyrus and left angular gyrus. In slow-4 band, BGIS patients showed greater increased DC values in the bilateral precentral gyrus. In slow-5 band, BGIS patients presented increased DC values in the left precuneus, bilateral caudate, left angular gyrus and vermis_4_5. Additionally, the DC values increased in the right caudate (r=0.400; p =0.019) and vermis_4_5 (r=0.431; p =0.011) in slow-5 band were positively correlated with NIHSS and the DC values increased in the right caudate (r=-0.339; p =0.050) were negatively correlated with BI in patients. Our findings showed that the DC changes in BGIS were frequency specific and the slow-5 band could be more sensitive to examine the DC changes, and revealed that the DC changes reflected the potential neurobiological mechanism of brain functional reorganization in patients with acute BGIS.
Influence of the Metal−Support and Metal−Metal Interactions on Pd nucleation and NO adsorption in a Pd4/γ-Al2O3 (110D) model
Authors: Prates Letícia M. , Carneiro José W. de M. , Cruz Maurício T. de M. 
Published: July 2022

Abstract
The role played by the metal − support (MSI) and metal − metal (MMI) interactions on two important processes in controlling the catalyst performance - nucleation and molecular adsorption – has been investigated using DFT (B3LYP) combined with LMOEDA and NBO calculations, with aid of a Pd4/γ-alumina (110D) model (Pd4/Al13O23H7). Our results indicate the occurrence of an electronic effect (EMSI) at the metal − support interface which induces a most intense charge transfer in the Pd4→γ-alumina backdonation direction, most expressive in Pd→Al, promoting an electronic redistribution within the units and attenuating the MMI. Nevertheless, the MSI/MMI synergistic effect seems to favor slightly the nucleation of a fifth palladium atom, leading to a distorted square pyramidal arrangement for Pd5. The LMOEDA analysis points to a mostly covalent character in the Pd − Al bonds, whereas the Pd − O bonds are mainly electrostatic in nature. The palladium atoms deposited on oxygen anions are the acid centers, where both NO molecule and an additional palladium atom anchor more strongly. In addition, the MSI/MMI effect, through the electronic and geometric contributions, drives the adsorption of the NO molecule to the mode which most favors the Pd→NO (4dz2→2π*) backdonation (bridge mode).
Achieving a Robust Mentoring and Research Capacity Program in a LMIC – The BRAINS Faculty Development Model
Authors: Ogunsola Folasade Tolulope , Sekoni Adekemi O. , Emmanuel Madonna , Manga-Atangana Bibiane , Caleb-Adepoju Sikeade Olawumi , Folarin Olalekan , Afolabi Bosede Bukola , Okubadejo Njideka Ulunma , Adeyemo Wasiu Lanre , Akanmu Alani Sulaimon , Osuntoki Akinniyi , Okonkwo Prosper , Murphy Robert , Kanki Phyllis 
Published: July 2022

Abstract
Background: A research and training program (RTP) was carried out to build capacity of faculty and improve the culture of research in the College of Medicine, University of Lagos (CMUL), Nigeria.Methods: Realist guided mixed methods evaluation of the BRAINS project was carried out using secondary data generated during the 5-years (2015 – 2020) of project implementation. The participants were trainee’s and mentees (45) currently faculty in the CMUL. Data was extracted from all project related documents including coursework biodata, workshop evaluation forms, quarterly project report and end of project report, submitted by the mentees, minutes of meetings and the proposal submitted for funding. It was in the form of continuous variables and prose (sentences & stories). Quantitative data was analysed with IBM SPSS statistics version 20 while the prose was thematically analysed to generate themes and narratives. Both were subsequently combined for interpretation and used to refine the initial programme theory into an evidence-informed theory.Results: Twelve courses were deployed, 1,418 participants (47.8% males and 52.2% females) from medical, nursing and allied medical departments were trained. Eighty participants were trained on Responsible Conduct of Research and Manuscript Writing over a three year period. Comparison of the pre/post-test knowledge scores showed a positive mean difference. Thematic analysis of workshop data produced three thematic domains representing effectiveness and gains namely: cognitive, reward and behavioural. 45 trainees were awarded grants and mentored, analysis of mentees data generated 4 themes: Achieving a robust mentoring program; Benefits of the mentoring program; Resilience in research; Improving the mentoring program. Conclusion: By contributing to the body of knowledge available on RTPs, this evaluation identified key components that contributed to the success of the project and developed a model for achieving a robust training and mentoring program which can be replicated in other LMICs.
An Improved Sparrow Search Algorithm for Deployment Problem in Wireless Sensor Network
Authors: Xie Jiazu , Zhang Cuiping 
Published: July 2022

Abstract
When designing and deploying wireless sensor network (WSN), sensor node deployment is one of the crucial issues for WSN providing high quality of service. Sensor node deployment could also affect network coverage, network connectivity, network lifetime, and energy consumption. This paper attempts to solve sensor node deployment problem in WSN. A mathematical model is constructed by considering coverage maximization, deployment strategy and other constraints. As the problem is non-deterministic polynomial (NP) complete, a new method called sparrow search algorithm (SSA) is used. A novel population structure is proposed to improve SSA to solve the problem. Two populations with central symmetry property are created in initialization. Crossover operator is used to exchange information of the two populations. The computational complexity of the improved SSA algorithm is also discussed. Numerical simulations are performed to solve the deployment problem in WSN. The improved SSA algorithm is tested and compared with other algorithms. The results show that the proposed method is useful to address NP complete sensor node deployment problem in WSN.
Fetal pancreas size and maternal serum biomarkers glycated albumin and insulin-regulated aminopeptidase provide no potential for early prediction of gestational diabetes mellitus
Authors: Guleroglu Filiz Yarsilikal , Ozmen Aliye Balkan , Bakirci Isil Turan , Dogu Sevilay Yavuz , Yilmaz Ibrahim , Cetin Ali 
Published: July 2022

Abstract
Purpose: We aimed to determine the predictive values of fetal pancreas size and maternal serum biomarkers glycated albumin (GA) and insulin-regulated aminopeptidase (IRAP) for gestational diabetes mellitus (GDM). Material and methods: In this prospective observational study including 109 pregnant women, the fetal pancreas size and maternal serum biomarkers GA and IRAP were measured at the gestational age of 20-22 weeks and later at the gestational age of 24-28 weeks, in 19 participants of them, GDM was confirmed with the 75-g oral glucose tolerance test (OGTT) and the fetal pancreas size was measured in all the participants again. Results: The median fetal pancreas sizes were significantly higher in women with or without GDM when measured at the 24-28 weeks of pregnancy compared to those at the 20-22 weeks of pregnancy (p<0.05). At both of the 20-22 and 24-28 weeks of pregnancy, the median values of fetal pancreas sizes in the women with or without GDM were found comparable (p>0.05). There were no significant differences between pregnant women with or without GDM regarding maternal serum biomarkers GA and IRAP (p>0.05). Conclusions: The fetal pancreas size and maternal serum biomarkers GA and IRAP provide no potential for early prediction of GDM at the 20-22 weeks of gestation. Further studies, including serial measurement of these parameters during second and third trimesters of GDM pregnancies, may clarify their role in the antenatal care of women with GDM.
Chemotherapy refusal and subsequent survival in older women with high genomic risk estrogen-receptor positive breast cancer
Authors: White McKenzie J. , Kolbow Madison , Prathiba Saranya , Praska Corinne , Ankeny Jacob , LaRocca Christopher , Jensen Eric H. , Tuttle Todd M. , Hui Jane Y. C. , Marmor Schelomo 
Published: July 2022

Abstract
Background: Patients with estrogen receptor (ER)-positive, HER2-negative breast cancer (BC) and high-risk 21-gene recurrence score (RS) results benefit from chemotherapy. We evaluated chemotherapy refusal and survival in older women with high-RS, ER-positive BC.Methods: Retrospective review of the National Cancer Database (2010-2017) identified women ³ 65 years of age, with ER-positive, HER2-negative, high-RS (³ 26) BC. Patients with Charlson Comorbidity Index ³ 1, stage III/IV disease, or incomplete data were excluded. Women were compared by chemotherapy receipt or refusal using the Cochrane-Armitage test, multivariable logistical regression modeling, the Kaplan-Meier method, and Cox’s proportional hazards modeling.Results: 6,827 women met study criteria; 5,449 (80%) received chemotherapy, 1,378 (20%) refused. Compared to women who received chemotherapy, women who refused were older (71 vs 69 years), were diagnosed more recently (2014-2017, 67% vs 61%), and received radiation less frequently (67% vs 71%) (p£0.05). Refusal was associated with decreased 5-year OS for women 65-74 (92% vs 95%) and 75-79 (85% vs 92%) (p£0.05), but not for women ³80 years old (84% vs 91%; p=0.07). On multivariable analysis, hazard of death increased with refusal overall (HR 1.12, 95% CI 1.04-1.2); but, when stratified by age, was not increased for women ³80 years (HR 1.10, 95% CI 0.80-1.51).Conclusions: Among healthy women with high-RS, ER-positive BC, chemotherapy refusal was associated with decreased OS for women ages 65-79, but did not impact the OS of women ≥ 80 years old. Genomic testing may have limited utility in this population, warranting prudent shared decision-making and further study.