bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gerakan Masyarakat Hidup Sehat Dengan Senam Oce-Dm (Orang Care Diabetes Melitus) Di Kecamatan Pondok Kelapa Kabupaten Bengkulu Tengah Provinsi Bengkulu
Authors: S Sunita R , Diah Halimatussa , Febriyanto Tedy , Suryani Desri , Fitriani Evi , Baruara Guntur 
Published: March 2022

ABSTRAK Diabetes Melitus (DM) ditandai dengan tingginya kadar glukosa dalam darah disertai dengan gangguan metabolisme karbohidrat, lipid dan protein sebagai akibat dari insufisiensi fungsi insulin. Peningkatan DM didasarkan oleh gaya hidup yang tidak sehat, banyak mengkonsumsi makanan berlemak, kurangnya aktivitas fisik sehingga tidak terkontrolnya kadar glukosa darah. Senam diabetes merupakan aerobic low impact dan ritmic, bermanfaat menurunkan kadar glukosa darah dan mencegah kegemukan serta menekan terjadinya komplikasi. Untuk menggerakan masyarakat untuk hidup sehat dan aktif melakukan pencegahan DM melalui aktivitas senam OceDM, di Kecamatan Pondok Kelapa Kabupaten Bengkulu Tengah Propinsi Bengkulu. Metode kegiatan berupa ceramah, praktek, diskusi dan partisipastif. Hasil kegiatan menunjukkan terbentuknya tim senam OceDM pada setiap 6 desa, senam selalu dilaksanakan penderita DM walaupun kegiatan sudah selesai. Terjadi penurunan nilai glukosa darah sebelum dan sesudah melakukan senam OceDM dan terbentuknya kader senam OceDM yang dapat menjadi promotor hidup sehat bersama diabetes militus. Kata Kunci: Diabetes Melitus, Senam OceDM, Glukosa Darah ABSTRACT Diabetes Mellitus (DM) is characterized by high blood glucose levels accompanied by impaired carbohydrate, lipid, and protein metabolism as a result of insulin function insufficiency. The increase in DM is based on an unhealthy lifestyle, consuming lots of fatty foods, lack of physical activity, so blood glucose levels are not controlled. Diabetes gymnastics is a low impact and rhythmic aerobic, useful for lowering blood glucose levels and preventing obesity, and suppressing complications. To mobilize people to live healthily and actively prevent DM through OceDM exercise activities in Pondok Kelapa District, Central Bengkulu Regency, Bengkulu Province. The method of activity is lecture, practice, discussion, and participatory. The results of the activity showed the formation of an OceDM gymnastics team in every six villages, and gymnastics was always carried out by DM patients even though the activities had been completed. There was a decrease in blood glucose values before and after doing OceDM exercise and the formation of OceDM gymnastics cadres who could be promoters of healthy living with diabetes mellitus. Keywords: Diabetes Mellitus, OceDM Gymnastics, Blood Glucose
Experimental and Numerical Investigation of Different Types of Jacketing Effect on Retrofitting RC Short Columns Using ECC Concrete
Authors: Dadmand Behrooz , Pourbaba Masoud , Riahi Ramin 
Published: March 2022

Given the deterioration of civil infrastructure throughout the world, developing more efficient repair and strengthening is essential. Jacketing is one of the most common methods for retrofitting reinforced concrete (RC) columns. Notably, using engineered cementitious composite (ECC) within the jacketing area increases the bearing capacity and significantly enhances the ductility of the columns. The recent development of ECC concrete with suitable compressive strength and higher ductility of about 5 % can significantly enhance the performance of reinforced concrete structures. The behavior of retrofitted RC columns depends heavily on the cohesion between the jacket and the original column as well as the mechanical properties of the jacketing materials. This study investigates jacketed square and circular RC columns using ECC and conventional/normal concrete (NC) using different casing techniques to retrofit RC columns, namely galvanized mesh, U and L-shape joints, removing the cover, core drilling, and integrated models. All specimens were subjected to a compression test. The results indicate that in both square and circular specimens, the use of ECC as a super ductile material and vertical U-shaped elements to connect the longitudinal rebars of the casing and the core leads to much higher ductility and bearing capacity than in NC specimens. These elements also showed suitable ductility because of using ECC as a super ductile material. In order to optimize these methods, finite element analysis (FEA) was conducted using Abaqus software to verify experimental models, as well as a parametric study to achieve an optimum design of the jacketing.
Desenvolvimento e aceitação sensorial de produtos elaborados com farinha de banana verde
Authors: Medeiros Angela de Fatima da Costa , Hautrive Tiffany Prokopp , Silva Maritiele Naissinger da , Bohrer Cariza Teixeira 
Published: March 2022

Este trabalho objetivou o desenvolvimento, a análise sensorial e a investigação quanto a intenção de compra de produtos de panificação à base de farinha de banana verde. Para tanto, realizou-se um estudo descritivo de abordagem quali-quantitativa, a partir da elaboração de três diferentes produtos de panificação (pão, cookie e bolo), à base de farinha de banana verde, os quais foram avaliados por meio da análise sensorial. Os resultados foram analisados estatisticamente, a um nível de significância de 5%. Observou-se que todos os atributos avaliados (aparência, aroma, textura e sabor) apresentaram correlação significativa entre si, e que houve diferença significativa entre os três produtos avaliados, com relação a cada um dos atributos. O cookie foi o produto com melhor aceitação entre todos os seus atributos avaliados, quando comparado ao pão e ao bolo. Quanto à intenção de compra, a melhor aceitação também foi do cookie, seguido do bolo e pão. Diante dos resultados obtidos no presente estudo, pode-se afirmar que o cookie e bolo, elaborados com a farinha de banana verde, tiveram uma boa aceitação pelos julgadores, podendo ser considerados produtos com boa aceitação no mercado. Para esses três produtos testados não foram necessários outros tipos de farinha.
Seleção de bactérias promotoras do crescimento vegetal produtoras de enzima: Efeito na decomposição de resíduos orgânicos
Authors: Franco Thaís Cristina , Oliveira Tayla Evellin de , Mantovani José Ricardo , Florentino Ligiane Aparecida 
Published: March 2022

Objetivou-se com essa pesquisa avaliar a produção de enzimas por bactérias promotoras do crescimento vegetal e o efeito da inoculação destas bactérias na decomposição de resíduos orgânicos e solubilização de fósforo. No primeiro experimento foram analisadas a produção das enzimas amilase e celulase por oito estirpes bacterianas. Esses testes foram realizados em meio de cultura e a presença das enzimas foram averiguadas pela formação de halo. O segundo experimento foi instalado em respirômetros adaptados, contendo solo, resíduos vegetais de feijão guandú (Cajanus cajan), brachiaria (Brachiaria decumbens) e controle sem adição de resíduo e adição de fosfato natural de Bayóvar, seguido ou não da inoculação com as estirpes bacterianas. As avaliações da evolução de C-CO2 foram realizadas semanalmente por um período de 42 dias. Após o período de avaliação do C-CO2 evoluído, o solo das câmaras de incubação foi utilizado para análise da concentração de fósforo. Como resultado foi verificado que a UNIFENAS 100-24 se mostrou potencialmente capaz de produzir amilase e celulose. Essa estirpe promoveu maior liberação de C-CO2, no entanto, não foi observado maior liberação de fósforo. A inoculação com a estirpe UNIFENAS 100-24 pode promover maior decomposição dos resíduos orgânicos, favorecendo a ciclagem de nutrientes e a melhoria da qualidade do solo.
PEMANFAATAN BOKASHI BERBAHAN LOKAL SEBAGAI PUPUK ORGANIK KAKAO DAN PAKAN IKAN AIR TAWAR TERBENAM DI DESA AMASARA KECAMATAN BAITO KABUPATEN KONAWE SELATAN
Authors: Syaf Hasbullah , Mardin Mardin 
Published: March 2022

Kecamatan Baito merupakan kecamatan pemekaran dari Kecamatan Tinanggea yang berada di Kabupaten Konawe Selatan. Kecamatan ini merupakan salah satu sentra produksi pangan dan perkebunan rakyat khususnya tanaman kakao dan budidaya ikan air tawar. Produksi tanaman ini terus menerus mengalami penurunan disebabkan dengan umur tanaman yang telah lanjut dan hama penggerek busuk buah kakao. Salah satu solusi adanya peremajaan tanaman melalui sambung samping. Kegiatan ini membutuhkan introduksi pupuk yang begitu banyak untuk menstimulir aktivitas pertumbuhan tanaman baru. Pupuk yang tersedia saat ini dari ketersediaan dan harga masih dirasakan oleh petani sebagai masalah yang utama. Ketersediaan pupuk kimia pada tingkat petani di Kecamatan Baito sangat rendah dan harga pupuk sangat mahal. Sehingga diperlukan bokashi berbahan lokal untuk mendampingi dan mengganti pupuk kimia. Di sisi lain, tingginya harga dan perolehan pakan ikan air tawar di rasakan petani sehingga diperlukan pengganti pakan yang ramah lingkungan melalui pemanfaatan bokashi berbahan lokal. Pengabdian ini bertujuan untuk mengubah prilaku petani, melaksanakan pelatihan/penyuluhan dan aplikasi teknik pembuatan dan penggunaan bokashi berbahan lokal di kebun kakao dan kolam ikan. Metode yang digunakan adalah percobaan langsung di lahan petani. Pengabdian dilakukan selama empat bulan dari bulan Juli hingga Oktober 2018. Di Desa Amasara. Pembuatan bokashi untuk kakao dan ikan air tawar dilakukan secara bersamaan. Hasil bokashi langsung diaplikas di kebun kakao. Sementara, pemanfaatan bokashi di kolam ikan petani dilakukan dengan membenamkan karungan bokashi disetiap sudut kolam. Hasil pelaksanaan kegiatan diperoleh: (a) telah terjadi perubahan prilaku dan peningkatan kepedulian petani di Desa Amasara dan sebaliknya adanya respon positif dari masyarakat sasaran terhadap program yang dilaksanakan; (b) telah dilaksanakan pelatihan/penyuluhan pembuatan bokashi untuk pemanfaatan pupuk organik dan pakan ikan terbenam dan (c) telah dilakukan kegiatan teknik penggunaan bokashi dilahan tanaman kakao rakyat dan teknik pemberian pakan ikan di kolam pembudiayaan ikan air tawar milik petani. Hasil di lapangan menunjukkan munculnya pucuk daun dan tunas muda pada tanaman kakao yang diberikan bokashi. Pada kolam ikan petani terjadi pertambahan bobot ikan nila dan mujair sebesar 15-20%, ikan emas sebesar 2-3%.
PENERAPAN SISTEM INFORMASI MANAJEMEN DAERAH DALAM MENDUKUNG TATA KELOLA KEUANGAN PUBLIK YANG BAIK DI KABUPATEN BUTON UTARA
Authors: Natsir Said Laode Muhammad 
Published: March 2022

Tujuan penelitian ini adalah mendeskripsikan dan menganalisis penerapan sistem informasi manajemen daerah dalam mendukung tata kelola keuangan publik yang baik. Penelitian menggunakan metode kualitatif, data kualitatif dari hasil wawancara dengan informan terpilih serta data sekunder dari organisasi terkait. Analisis data dilakukan secara deskripsi kualitatif. Kesimpulan, penerapan sistem informasi manajemen daerah dalam pengelolaan keuangan sektor publik dilaksanakan dengan memenuhi komponen sistem pendukung SIMDA keuangan yaitu penyediaan personil pelaksana, penyediaan perangkat teknologi komputerisasi beserta kelengkapannya termasuk program aplikasi SIMDA keuangan, penyediaan basis data dan operasional SIMDA untuk menghasilkan output sesuai kebutuhan pengelolaan keuangan daerah dalam hal perencanaan, penganggaran, penatausahaan, pelaporan berupa pengelolaan gaji dan barang milik daerah.
Advanced Oxidative Protein Products Drive Trophoblast Cells Into Senescence by Inhibiting the Autophagy: The Potential Implication of Preeclampsia
Authors: Li Zhengjuan , Wang Shuoshi , Li Liping 
Published: March 2022

Introduction:Advanced oxidation protein products (AOPPs), the novel marker of oxidative stress, have been found to be elevated in preeclampsia (PE). To date, the effect of AOPPs on the senescence of trophoblast cells is still unclear. In this study, we investigated whether AOPPs promoted the senescence of trophoblast cells and explored the underlying mechanisms of AOPPs-induced aging process which may facilitate the progression of PE.Methods:The trophoblast cell line HTR-8/SV neo cells were cultured in the presence of PBS, AOPPs, AOPPs plus an anti-oxidant N-acetyl-L-cysteine (NAC). In some experiments, cells were pre-treated with rapamycin (an activator of autophagy), 3-MA (an inhibitor of autophagy), or cyclic pifithrin-α (PFT-α, an antagonist of p53), and then treated with AOPPs. Cellular senescence was analyzed by measuring the levels of senescence-associated β-galactosidase (SA β-Gal), senescence-associated heterochromatin foci (SAHF), mitochondrial membrane potential (ΔΨm), and cell cycle. Cell autophagic flux was analyzed by measuring tandem fluorescence-tagged LC3 reporter (mCherry-EGFP-LC3). Levels of p53, phosphorylated p53 (p-p53), p21, BECN1, p62,p-mTOR andp-p70S6K were measured by western blot.Results:Treatment with AOPPs significantly increased the levels of SA β-Gal and SAHF, the percentage of cells in the G0/G1 phase, and decreased cell ΔΨm compared with the control group. Co-treatment with NAC and AOPPs significantly reversed AOPPs-induced senescence. Pre-treatment with rapamycin or 3-MA significantly inhibited or promoted AOPPs-induced senescence, respectively. In addition, administration of AOPPs significantly decreased the numbers of mCherry+EGFP+autophagosomes and mCherry+EGFP-autolysosomes in cells compared with cells treated with PBS. Furthermore, AOPPs significantly increased the levels of proteinsp-p53, p21,p-mTOR andp-p70S6K compared with the control group. Pre-treatment with rapamycin or PFT-α significantly down-regulated the levels of SAβ-Gal, SAHF, p-p53, p21, autophagy related protein p62, the percentage of cells in the G0/G1 phase, and significantly up-regulated ΔΨm, autophagy related protein BECN1, autophagosomes and autolysosomes compared with cells only treated with AOPPs.Conclusion:AOPPs may induce trophoblast cell senescence by inhibiting the autophagy process in a p53/mTOR/p70S6K-dependent pathway.
Extracellular Vesicles From LPS-Treated Macrophages Aggravate Smooth Muscle Cell Calcification by Propagating Inflammation and Oxidative Stress
Authors: Yaker Linda , Tebani Abdellah , Lesueur Céline , Dias Chloé , Jung Vincent , Bekri Soumeya , Guerrera Ida Chiara , Kamel Saïd , Ausseil Jérôme , Boullier Agnès 
Published: March 2022

Background: Vascular calcification (VC) is a cardiovascular complication associated with a high mortality rate among patients with diseases such as atherosclerosis and chronic kidney disease. During VC, vascular smooth muscle cells (VSMCs) undergo an osteogenic switch and secrete a heterogeneous population of extracellular vesicles (EVs). Recent studies have shown involvement of EVs in the inflammation and oxidative stress observed in VC. We aimed to decipher the role and mechanism of action of macrophage-derived EVs in the propagation of inflammation and oxidative stress on VSMCs during VC.Methods: The macrophage murine cell line RAW 264.7 treated with lipopolysaccharide (LPS-EK) was used as a cellular model for inflammatory and oxidative stress. EVs secreted by these macrophages were collected by ultracentrifugation and characterized by transmission electron microscopy, cryo-electron microscopy, nanoparticle tracking analysis, and the analysis of acetylcholinesterase activity, as well as that of CD9 and CD81 protein expression by western blotting. These EVs were added to a murine VSMC cell line (MOVAS-1) under calcifying conditions (4 mM Pi—7 or 14 days) and calcification assessed by the o-cresolphthalein calcium assay. EV protein content was analyzed in a proteomic study and EV cytokine content assessed using an MSD multiplex immunoassay.Results: LPS-EK significantly decreased macrophage EV biogenesis. A 24-h treatment of VSMCs with these EVs induced both inflammatory and oxidative responses. LPS-EK-treated macrophage-derived EVs were enriched for pro-inflammatory cytokines and CAD, PAI-1, and Saa3 proteins, three molecules involved in inflammation, oxidative stress, and VC. Under calcifying conditions, these EVs significantly increase the calcification of VSMCs by increasing osteogenic markers and decreasing contractile marker expression.Conclusion: Our results show that EVs derived from LPS-EK–treated-macrophages are able to induce pro-inflammatory and pro-oxidative responses in surrounding cells, such as VSMCs, thus aggravating the VC process.
Thoracoscopic Trans-mitral Septal Myectomy for Hypertrophic Obstructive Cardiomyopathy in the Elderly
Authors: Wei Peijian , Liu Jian , Ma Jiexu , Liu Yanjun , Tan Tong , Wu Hongxiang , Zhu Wei , Chen Zhao , Chen Jimei , Zhuang Jian , Guo Huiming 
Published: March 2022

BackgroundThe thoracoscopic trans-mitral approach can not only facilitate exposure of the ventricular septum, mitral valve, and subvalvular apparatus, it also enables the surgeons to perform concomitant mitral valve intervention. This study aimed to determine the safety and efficacy of thoracoscopic trans-mitral septal myectomy in elderly patients with hypertrophic obstructive cardiomyopathy (HOCM).MethodsWe reviewed the demographic to clinical characteristics and outcomes of patients who underwent thoracoscopic trans-mitral septal myectomy in our center between April 2019 and April 2021. The population was divided into a younger group (&lt;60 years) and an elderly group (≥60 years).ResultsThere were 46 and 20 patients in the younger and elderly groups, respectively. The majority of patients in the elderly group were female (39.1 vs. 80.0%, P &lt; 0.01). Patients in the elderly group were more likely to be in New York Heart Association Class IV (2.2 vs. 80.0%, P &lt; 0.01). The European System for Cardiac Operation Risk Evaluation II predicted mortality rates were significantly higher (3.97 ± 1.81 vs. 1.62 ± 0.86%, P &lt; 0.01) in the elderly group. In the elderly group, a patient converted to median sternotomy due to left ventricular posterior free wall rupture following septal myectomy and mitral bioprosthetic valve replacement. The patient then underwent double-patch sandwich repair for rupture and mitral mechanical valve replacement and was eventually discharged. All patients in the elderly group were discharged, while one in the younger group died. No patient in the elderly group required permanent pacemaker implantation vs. one in the younger group. Patients in the elderly group were more likely to spend more time in the intensive care unit than those in the younger group (5.44 ± 5.80 days vs. 3.07 ± 2.72, P &lt; 0.05). However, there was no significant intergroup difference in in-hospital mortality or complications. Importantly, the left ventricular outflow tract pressure gradient was significantly decreased from 96.15 ± 32.89 mmHg to 8.2 ± 3.42 mmHg with no residual obstruction in the elderly group. The interventricular septal thickness was significantly decreased from 19.73 ± 3.14 mm to 11.30 ± 2.23 mm. Postoperative mitral regurgitation severity was significantly improved in the elderly group.ConclusionThis study demonstrated that thoracoscopic trans-mitral septal myectomy is a feasible option for selected elderly patients with satisfactory outcomes similar to those of young patients.
Modelling Fault Scarp Degradation to Determine Earthquake History on the Muztagh Ata and Tahman Faults in the Chinese Pamir
Authors: Lu Lejun , Zhou Yu , Zhang Peizhen , Cheng Xiao 
Published: March 2022

The frequency of earthquakes on active faults is usually revealed by palaeoseismic trenching and geological dating. Nonetheless, field trenching and sampling are sometimes limited by difficulties in logistics, therefore impeding palaeoseismological studies. As surface rupture earthquakes create fault scarps that evolve with time, they may also provide important information about the timing of earthquakes. In this study, we provide a new approach to determine earthquake history based on the morphology of fault scarps. We select the Muztagh Ata and Tahman normal faults in the Chinese Pamir as a test area, on which fault scarps are well preserved but the earthquake history has not been quantified yet. We first simulate fault scarp degradation using a nonlinear transport model to obtain the empirical relationship between scarp width and its evolution time. We then measure 68 fault scarps from high-resolution topographic data derived from WorldView-2 stereo imagery. The measured fault scarps are clustered in four groups, each group possibly representing one earthquake event. Combining the time-width relationship and scarp width measurements, we infer that four earthquakes occurred at 0.1±0.4 kyrs before the present (BP), 2.1±0.5 kyrs BP, 2.9±0.4 kyrs BP and 4.9±0.5 kyrs BP, respectively. The first event is likely to be the most recent earthquake occurred on the faults, i.e., the 1895 Tashkurgan earthquake ( ∼0.13 kyrs BP). Based on the estimated earthquake recurrence intervals and vertical offsets, we obtain a vertical slip rate of 2.2±0.3 mm/yr on the Muztagh Ata and Tahman faults, conforming to previous geological rate estimates.
Study on Influence of Heavy Oil Reservoir Damage Caused by Multi-Component Thermal Fluid Huff and Puff
Authors: Yu Xinan , Liu Xilei , Chen Mingming , Wu Guanghuan , Li Xiaoping 
Published: March 2022

Multi-component thermal fluid (MCTF) huff and puff technology is an innovative heavy oil development technology widely used in China offshore oilfields. MCTFs mainly include steam, N2 and CO2. Under high temperature and high pressure, the physical and chemical reactions between thermal fluids and rocks occur, damaging the reservoir permeability and production effect. In this paper, 16 groups of core comparison experiments were carried out by MCTF device, the influence of original permeability, temperature and component on reservoir damage was quantitatively studied, and a mathematical model was established. Finally, the influence of reservoir damage on heavy oil development was investigated through numerical simulation. The experimental study reveals that MCTF has an obvious damage effect on the reservoir, where temperature and PV dominate the damage degree; with the increase of MCTF injection volume (PV), the core permeability rapidly decreases initially and stabilizes later (&gt;6 PV). The numerical simulation results show that reservoir damage could lead to a recovery drop by 6.9% during MCTF development; on the premise of considering reservoir damage, MCTF huff and puff will further improve oil recovery by 9.68% compared with pure steam. The research is of great significance for understanding the production law of MCTF huff and puff and helpful for promoting the development of offshore heavy oil reservoir.