bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphorus and water supply independently control productivity and soil enzyme activity responses to elevated CO2 in an understorey community from a Eucalyptus woodland.
Authors: Piñeiro Juan , Ochoa-Hueso Raúl , Serrano-Grijalva Lilia , Power Sally A. 
Published: June 2022

Abstract
Aims: While it is well-established that nitrogen (N) availability regulates elevated [CO2] (eCO2) effects on plant growth and soil carbon (C) storage in N-limited environments, there are fewer studies investigating the role of phosphorus (P) supply on such responses in P-limited environments. In this study, we explored whether P fertilization influences plant growth, soil enzyme activity and C fluxes responses to eCO2, and determined how different levels of water availability regulate these processes.Methods: We used soil collected from a temperate, P-limited Eucalyptus woodland containing the native soil seed bank to grow a potted replica of local understory communities. We exposed the emerging communities to eCO2 under two contrasting water levels and two levels of P fertilization. We assessed plant biomass allocation, the rhizosphere activity of extracellular enzymes related to C, N and P cycles, as well as CO2 fluxes.Results: The positive effects of eCO2 on plant production and ecosystem C dynamics were strongly constrained by low levels of P availability. Our data also suggest that plant and microbial mechanisms that increase nutrient release from SOM may not be able to overcome this P limitation. Modest increases in water are unlikely to have a major impact on these responses.Conclusions: While current Earth System Models predict positive feedback responses of terrestrial ecosystems on C storage under eCO2, here we emphasize the importance of accounting for the widespread phenomenon of P-limitation in such responses.
New PS modified Epoxy-based Nanoclay and Hybrid Composites: Mechanical, Thermal, and Flammability Properties
Authors: Ozmeral Nimet , Soydal Ulku , Kocaman Suheyla , Ahmetli Gulnare 
Published: June 2022

Abstract
In the first stage of this study, the epoxy resin-hardener system, which was used in modification with thermoplastic polystyrene (PS) waste, was determined. For this purpose, different epoxy resins: bisphenol-A type (ER) and phenolic novolac (EPN) epoxy resins and modified cycloaliphatic amine type different curing agents were tried, and the EPN-IPOX system was found suitable. The curing degrees of the neat ER, EPN, and modified EPN (EPN-PS) resins calculated from the FTIR spectra were found as 99.3%, 99.9%, and 86.5%, respectively. The increase in the degree of curing increased the density values. Pristine (NC) and chemically modified (MNC) montmorillonite nanoclays were used in the preparation of nano- and hybrid composites. Chemical modification was accomplished by treating NC particles with tetramethylammonium chloride (TMAC). Chemical structures of nanoclays were elucidated by FTIR. The appropriate ratio of PS and NC was accepted as 4% and 2% by weight, respectively. Hybrid composites were produced at a fixed NC or MNC ratio of 2% by weight, with red mud waste (RMW) released during the production of alumina from bauxite. The surface morphology of nano- and hybrid composites was characterized by Scanning electron microscopy (SEM) and X-ray diffraction (XRD). A comparative study of the influence of 1–4 wt% pristine NC, and two-types binary systems; (a) 2 wt% NC-(15–35) wt% RMW; and (b) 2 wt% MNC-(15–35) wt% RMW on the mechanical, dynamic mechanical, and thermal properties of modified epoxy resin (EPN-PS) was investigated. Combustion of the EPN-PS matrix decreased with adding NC/MNC and RMW.
Machine Learning in Production: From Experimented ML Model to System
Authors: Bhowmik Pritom 
Published: June 2022

Abstract
Production ML pipeline refers to a complete end-to-end workflow of a machine learning product ready for deployment. In recent years, companies have vastly invested in Machine Learning research; developers are developing new tools and technologies to make ML more flexible. Now, we can experience AI in most devices around us, from home appliances to cars. When we want to develop an AI-powered product, it is vital to understand the crucial workflows of the ML. Academic research to develop an ML model and a production ML pipeline are entirely different scenarios. From business problems, data collection to deploying the model is an acutely iterative process. Most of the time, Data scientists and Machine Learning Engineers need to deal with issues like data shift, concept shift, model decay, etc. Sometimes, there are need to change the complete ML architecture or how the features are engineered in the dataset. It will become tedious if someone is working in such an environment and lacks an understanding of the entire workflow of the ML pipeline. Though every ML project is different, a data scientist/ ML engineer/ data engineer must understand the end-to-end workflow of the ML pipeline for the product they are developing. The challenge starts with a business problem. We may face different domain problem statements that need to be solved with Machine Learning. How the data will be collected is also a big concern. Data pre-processing, data validation, data monitoring, feature engineering, Model Selection, hyperparameter tuning, model optimization, model performance analysis, performance evaluation, detecting bias, model deployment, post-deployment analysis & monitoring are the crucial processes to make your model production-ready. The main contribution of this research paper is to present a complete picture of the end-to-end workflows of a production-ready ML pipeline. The process can apply to any production ML project though some workflow or steps may differ due to the domain or use-case's demand. A proper ML pipeline architecture should be easily maintainable, scalable, and reusable. Because as the machine learning project grows, it becomes more and more complex. So, performing regular updates and scaling will become easy for data scientists & ML engineers if the pipeline is well designed and automated.
Impact of different invasion methods of invasive species on omnivorous food webs
Authors: Jiabu Duojie , Li Weide 
Published: June 2022

Abstract
Habitat loss and habitat fragmentations are the two main characteristics of habitat destruction and one of the main drivers of biological extinction. So far, many studies have made progress in theoretical studies of spatial food webs, but research on the effects of invasive species in omnivorous food webs is still lacking. Therefore, studying the impact of invasive species on omnivorous food webs in landscapes characterized by habitat loss and fragmentation is necessary. We first developed a simple model of an omnivorous food web. An invasive species with different roles was introduced into this simple omnivorous food web to construct different food web structures. In this different food web that we consider the predation relationship between species, competition, and different dispersal types. Our model simulation results show that the structure of the omnivorous food web formed after the invasion becomes significantly more complex and forms more food chains than before the invasion. There is competition between invasive and native species in the different omnivorous food web structures formed after the invasion. The results of our simulations show that this competition can lead to invasive species that will exclude native species or native species that will defeat invasive species. Overall, our study of this theoretical biological invasion model provides new insight into the actual biological invasion phenomenon.
Predictive value of 6-hour lactate clearance rate for mortality rate of septic shock patients with age stratification
Authors: Jin Chunhua , Jiang Longlin , Wang Liquan 
Published: June 2022

Abstract
Objective: Early lactate clearance was associated with mortality in sepsis patients, but needs further clarification whether it should be adjusted according to the age. Our study aimed to investigate the predictive value of early 6-hour lactate clearance rate with the mortality rate of septic shock patients according to age stratification.Methods and Results: This was a prospective, single center and observational study. A total of 261 patients with mean age of 69.5 years were enrolled. Male patients accounted for 61.6%, with a total mortality rate of 47.5%. The blood lactate levels (LAC1) of patients showed no significnat differences between Survival Group and Death Group (P=0.767) during ICU admission. However, after 6-hour treatment, the blood lactate levels of patients in Survival Group were significantly lower compared to Death Group (P<0.001), and similar are the results of 6-hour lactate clearance rate (P<0.001).Multivariate Logistic regression indicated that age ( and lactate clearance rate were significantly associated with 28-day mortality rate. The AUC value of ROC curve for lactate clearance rate was 0.800. AUC value of ROC curve for patients >65 years and ≤65 years was 0.778 and 0.845. AUC value of ROC curve for patients >80 years and ≤80 year old was 0.751 and 0.818. However, the lactate clearance rate showed no significant differences between Survival Group patients of different age (P= 0.5413 and P=0.338), respectively.Conclusion: In clinical practice, The blood lactate levels (LAC1) of patients showed no significnat differences between Survival Group and Death Group,but early 6-hour lactate clearance rate could be used to predict the mortality rate of patients with age stratification, with optimal accuracy.
Elevated NT-ProBNP levels are associated with CTP ischemic volume and 90- day functional outcomes in acute ischemic stroke: a retrospective cohort study
Authors: Shen Xiaozhu , Xu Yiwen , Liu Mengqian , Nan Dong , Fang Qi , Zhang Xianxian , Liao Juan , Jiang Yi , Yu Liqiang , Chen Qingmei 
Published: June 2022

Abstract
Objective: To investigate the impact of N-terminal pro-B-type natriuretic peptide (NT-proBNP) on CTP infarct core volume and poor 90-day functional outcomes in acute ischemic stroke (AIS). Methods: A total of 403 hospitalized patients with AIS in the Stroke Center of the First Hospital Affiliated to Soochow University were enrolled from March 2018 to January 2021. The association between NT-proBNP and clinical outcomes in acute ischemic patients was assessed by logistic regression and adjusted for confounding factors. Also, subgroup analyses were conducted based on treatment decisions. Results: NT-proBNP was positively correlated with CTP ischemic volume (p<0.001), infarct core volume (p<0.001), and ischemic penumbra volume (p<0.001). Univariate analysis showed that the influence of NT-proBNP and functional outcomes were statistically significant in model 1 (p=0.002). This phenomenon was persistent after adjusted for age, sex, and body mass index in model 2 (p=0.011), adjusted for SBP, current smoking, family history of stroke, hypertension, and diabetes mellitus in model 3 (p<0.001), and adjusted for TnI, D-dimer, PLT, Cr, TC, TG, HDL-C, treatment decisions, and NIHSS score in model 4 (p=0.027). A high NT-proBNP was associated with a high 90-days mRS score among the total population, IV rt-PA, and standardized treatment groups, but not in IV rt-PA+EVT, EVT, and EVT/IV rt-PA+EVT groups.Conclusion: Elevated NT-ProBNP levels reveal large CTP infarct core volume and poor 90-day functional outcome in AIS. NT-pro BNP is an independent risk factor for functional outcomes, while endovascular treatment could counteract the role of NT-proBNP as a biomarker for predicting poor outcomes.
Erosion Source Area Identification Using Rusle and Multi-criteria Decision Analysis, Acase of Andassa Watershed, Upper Blue Nile Basin
Authors: Tegegne Moges Animut , Wosenie Mekete Dessie , Kumlachew Yibeltal Zewudu , Melsse Dessie Wubetu , Hayi Solomon Kasaa 
Published: June 2022

Abstract
Soil erosion reduces the productive capacity of the land, which leads to global food insecurity, decline landscape beauty, decrease quality of water, loss of aquatic lives in water bodies, and Catchments. Generally, Soil erosion problems disturbs the whole ecological process. The results of the study show that mean annual soil loss of Andassa watershed was about 68 t ha1 year-1. From soil erosion factors, Topographic wetness index followed by land use land cover have been found to have significant effect on soil erosion in the watershed. The combined result of MCE and RUSLE result showed that 21.17% of Andassa watershed was highly sensitive, 23.17% moderately sensitive, 46.78% slightly sensitive, 8.31% currently not sensitive and 0.04% were constraint to soil erosion. Based on these results, the watershed has significantly at high to moderate risk of soil erosion (44.34%) from the hole watershed. Thus, the Upper part of the watershed is under high class of soil erosion source and needs immediate attention in terms of management as well as planning perspective and it should be managed for conservation and environmental protection activities. From the overall combined map of Multicriteria decision analysis (MCDA) and revised universal soil lose map showing the areas of increased risk erosion represented by highly sensitive (S1), moderately sensitive(S2), less sensitive(S3), and non-sensitive(S4) areas so the governmental or non-governmental organizations or any concerned organization should refer this important severity map of soil erosion for watershed management and priority of the watershed.
Post-operative outcome in emergency surgical interventions in patients with right sided colon cancer. A nation-wide population- based study Danish Colorectal Cancer Group (DCCG) register
Authors: El-Hussuna Alaa , Knudsen Maria , Frasson Matteo , Poulsen Laurids Østergaard 
Published: June 2022

Abstract
Aim: to identify modifiable risk factors associated with short term post-operative complications in this group of patients. in patients with right sided colon cancer (RCC) who undergo emergency surgical interventions.Methods: This was a retrospective nation-wide study based on a prospectively maintained Danish Colorectal Cancer Group database. Results: A total of 2740 patients fulfilled the inclusion criteria of which 2464 had definitive surgical procedure in form of segmental colon resection (89.9%). Older patients (OR 1.032 CI 95 % [1.009-1.055] p= 0.005) and patients with high ASA score (OR 1.61 CI 95% [1.422-1.830] p<0.001) had higher rates of sever post-operative complications (grade 3b and above as classified by Clavian-Demartines-Dindo classification). De-functioning procedures i.e., stoma construction or colonic stent (without oncological resection) did not reduce the risk of complications compared to definitive surgery. The 30-day and 90 days post-operative mortality rates were significantly reduced over the time of the study (OR 0.943 CI 95% [0.922-0.965] p<0.01) and OR 0.953 CI 95% [0.934- 0.972] p<0.01) respectively. Compared with European Society Colo-Proctology snapshot audit in 2015 showed less occurrence of intra-abdominal septic complications 29/212 (13.7%), wound infection 43/253 (17%) and unplanned intra-operative adverse events 26/235 (10.3%) in the Danish cohort compared to the international cohort.Conclusion: Age and ASA score were risk factors for sever post-operative complications. De-functioning procedure did not protect these patients from the high risk of post-operative complications nor post-operative 90-day mortality. This study can be a baseline to evaluate the effect of pre-operative optimization in this group of patients.
Chalcone Derivative B8HA as A Novel Histone Deacetylase and Tubulin Dual-targeting Inhibitors, Inhibits Triple-Negative Breast Cancer Cells Proliferation
Authors: Li Kangkang , Zheng Qiuling , Qi Shulei , Xie Yi , Chen Xuehong 
Published: June 2022

Abstract
Purpose Designing and synthesizing dual- and multi-target drugs have raised considerable interests due to their advantages in improving potencies as antitumor agents. In previous studies, our group designed and synthesized a series of novel chalcone based tubulin and histone deacetylase (HDAC) dual-targeting inhibitors. Among them, compound B8HA exhibited promising potency for the treatment of triple-negative breast cancer. In this work, we highlighted its biological evaluations in MDA-MB-231 and 4T1 cells.Methods The in vitro antiproliferative efficacies of compound B8HA against MDA-MB-231, MDA-MB-468, MCF-7, 4T1, A549, HCT-116, HT-29 and K562 were evaluated with MTT assay. Moreover, the potencies of B8HA as inhibitors of HDAC and tubulin polymerase were also evaluated in vitro and vivo.Results Comparing to the classical HDACi SAHA, B8HA has higher potency to induce apoptosis and inhibits the migratory and invasive abilities of tumor cells under the same dose in vitro and vivo. B8HA as tubulin inhibition is also able to inhibit the formation of capillary-like structures as well as to disrupt existing tubules.Conclusion These results indicated that compound B8HA is a potent inhibitor of both HDAC and tubulin, leading to excellent in vitro and in vivo antiproliferative activities.
Spectroscopic Characterization of Subsurface Thermal Degradation of Eu:Y(acac)3(DPEPO) in an Opaque Medium Using Wavefront-shaping Assisted Bidirectional Focusing
Authors: Anderson Benjamin R. , Gese Natalie , Eilers Hergen 
Published: June 2022

Abstract
We characterize the subsurface thermal degradation of an inert analogue of energetic molecular crystals (Eu:Y(acac)3(DPEPO)) using a wavefront-shaping assisted bidirectional focusing microscope. This microscope provides the capability to focus inside of a heterogeneous material and measure both Raman and fluorescence spectra during thermal degradation. From these measurements we find that embedding the molecular crystal in the polymer results in improved thermal stability as the polymer acts to constrict the effects of melting, which is the primary mechanism for spectroscopic changes for this material in the temperature range explored. Additionally, we identify a significant challenge in the microscope with regards to signal arising from out of focus guidestar particles and scattering particles. To address this issue we propose the use of spatial filtering of the output signal to remove unwanted signal while keeping the in-focus signal.
Sphingosine 1-phosphate Receptor 2 Mediated Early Stages of Pancreatic and Systemic Inflammatory Response via NF-kappa B Activation in Acute Pancreatitis
Authors: Yang Jing , Tang Xujiao , Li Baiqiang , Shi Jinsong 
Published: June 2022

Abstract
In acute pancreatitis (AP), activation of inflammatory signaling including nuclear factor-kappa B (NF-κB) pathway within acinar cells is known to be an early intracellular event occurring in parallel with pathologic trypsinogen activation. Sphingosine 1-phosphate Receptor 2 (S1PR2) plays a critical role in endothelial inflammation and our previous studies reported that S1PR2 deficiency significantly reduced inflammatory response in liver injury under cholestasis conditions. However, the role of S1PR2 in inflammatory signaling activation within acinar cells and inflammatory responses during acute pancreatitis has not been elucidated. Here we report that S1PR2 was upregulated in whole pancreas during acute pancreatitis conditions. Blockade of S1PR2 by pharmacologic inhibition of S1PR2 by JTE-013 or AAV-mediated knockdown of S1PR2 improved the severity of pancreatic injury as indicated by significant reduction of inflammation and acinar cells death in acute pancreatitis mice. Moreover, S1PR2 is the predominant S1PRs expressed in pancreatic acinar cells and mediates NF-κB activation and early inflammatory response within acinar cell under acute pancreatitis conditions via ROCK signaling pathways, not extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. In addition, S1PR2 mediated macrophages NF-κB activation, migration and polarization toward M1 phenotype. Therefore, this results demonstrated that S1PR2-mediated early inflammatory response in acinar cell promote the progression of acute pancreatitis, successfully linking the local events to the systematic inflammatory response and leading a novel therapeutic target for acute pancreatitis aimed at halting the progression of inflammatory response.
Long-term profound investigation of Fenoxaprop-p-ethyl and indirect pesticide pollution in jute cropped-environmental ecosystem for dietary and ecological risk assessment
Authors: Bhattacharyya Sudip , Poi Rajlakshmi , Sen Moni Baskey , Hazra Dipak Kumar , Mandal Swagata , Karmakar Rajib 
Published: June 2022

Abstract
Jute is a healthy vegetable due to its high content of carotenoids, vitamins, and minerals, in addition to its industrial utility. The purpose of this study was to look into the dissipation of fenoxaprop-p-ethyl and to track indirect sources of pesticide accumulation in jute ecosystems for three years in a row during tropical monsoon seasons. To avoid the intake of residues over approved limits, a rapid extraction technique was developed to evaluate the residues of this herbicide (Whip-Super 9% EC) in jute leaves, fiber, cropped soil, and water. A modified QuEChERS approach based on liquid chromatography and UV-VIS detection was developed and successfully validated in accordance with SANCO requirements. GC-MS was used to examine fish and water samples from jute fields and retting pond for twenty widely used multi-class pesticide contaminations from indirect sources. Acceptable value of recoveries (100-115%) and relative standard deviations (RSD) (≤20) are observed. In edible jute leaves, independent of season, first-order kinetics of dissipation was recorded, with half-lives ranging from 0.61 to 0.68 days. Based on the findings of the risk assessment, it is feasible to conclude that the consumer health risks of ingesting jute leaves are insignificant, even on day zero, when used at the recommended amount, and that using jute bags for food packaging and storage is safe. But jute field water was found to be less polluted with indirect pesticides than water from a nearby jute retted pond. Fish samples from this jute retted pond water were also analysed and found to be 26% contaminated. The presence of quinalphos and chlorpyriphos in jute retting water and fish might pose a concern to consumer health and environmental eco-systems.