bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interlaboratory comparison of voltage sweep methods used for the electrical characterization of encapsulated high‐efficiency c‐Si solar cells
Authors: Zhang Yating , Monokroussos Christos , Wilterdink Harrison , Müllejans Harald , Pavanello Diego , Yoshita Masahiro , Yamagoe Kengo , Ramspeck Klaus , Hinken David , Bothe Karsten , Fujita Yuji , Arnoux Gilles , Pinto Filipe , Ambigapathy Rajesh , Gao Qi , Shi Qiang , Chen Yi Feng , Ping Yan 
Published: October 2022

AbstractThis work presents the comparison of measurement results for four types of encapsulated high‐efficiency c‐Si solar cells measured by 10 laboratories based in Asia, Europe and North America utilizing a wide range of voltage sweeping methods, which include well‐established procedures that represent good industry practice, as well as recently introduced ones that have not been verified yet. The aim of the round‐robin interlaboratory comparison was to examine the measurement comparability of different laboratories with respect to their measurement methods of high‐efficiency solar cells. A proficiency test was employed to examine the consistency of results and their corresponding uncertainties. The short‐circuit current (ISC) under STC measured by four accredited laboratories was firstly compared. In order to investigate the consistency related to the high device capacitance, the value of the ISC was fixed for all 10 participants. The results of all participant laboratories—compared via En number analysis—generally remained well within [−1; 1], thus indicating consistency between the measured values and the reference values within stated measurement uncertainties. The differences remained within ±1.15% in PMAX and within ±0.35% in VOC for all participants and methods applied. Correlations were observed among the PMAX, VOC, and FF differences from their weighted mean. An analysis of the effects of transient current (dQ/dt) at maximum power point caused by hysteresis effect on the measurement error of PMAX showed a significant linear correlation between error of maximum power and junction voltage sweep rate for heterojunction (HJT) solar cells. This work forms the basis to validate all applied methods and their stated measurement uncertainties.
Study on a Novel Synthetic Route and Properties of 1‐trinitromethyl‐3‐nitro‐1,2,4‐triazole (TNMNT)
Authors: Yanwu Yu , Yuan Guo , Haodong Zhao , Hongbin Wang , Hui Ma , Jiahu Guo , Suming Jing , Guimin Cheng , Xiaodan Wang , Yuanfeng Zhao 
Published: October 2022

AbstractMaterials with low melting point and high energy density have become the focus of research on energy‐containing materials thanks to their superb detonation performance and wide applications. This paper proposed a new synthetic route for an energy‐containing compound 1‐trinitromethyl‐3‐nitro‐1,2,4‐triazole (TNMNT), using 3‐nitro‐1,2,4‐triazole as the raw material, low toxic chloroacetone as the substitute and KBr as the catalyst. These substances reacted at 70 °C for 3 h in a DMF reaction solvent system. The intermediate 1‐acetonyl‐3‐nitro‐1,2,4‐triazole (ANT) was obtained with a yield of 38 %. The nitration process increased the volume ratio of mixed nitric and sulfuric acids (1 : 3), and the reaction time was 36 h. TNMNT as a nitrogen‐rich compound having low melting point and high energy density was synthesized with a yield of 43 %. Compared with the traditional process, the experimental period was significantly shortened, and this synthetic method proved more environment‐friendly. Scanning Electron Microscopy (SEM), Differential Scanning Calorimeter (DSC) and mechanical sensitivity tests were performed on the products. It was found that the melting and decomposition points of TNMNT were 100.5 °C and 166.4 °C, respectively, the characteristic drop height H50 was 21.3 cm, and the frictional sensitivity was 56 %. Results show that the TNMNT crystals synthesized by this new route have better morphology, higher purity, and lower melting point. Compared with the raw material, the introduction of the trinitromethyl group produced higher mechanical sensitivity than other compounds having low melting point. Calculation of the thermal decomposition parameters found: activation energy of 104.4 kJ ⋅ mol−1, pre‐exponential factor of 2.27×1010 s−1, activation enthalpy of 100.9 kJ ⋅ mol−1, activation entropy of 57.98 J ⋅ mol−1 ⋅ K−1, and activation free energy of 125.72 kJ ⋅ mol−1.
RCSB Protein Data bank: Tools for visualizing and understanding biological macromolecules in 3D
Authors: Burley Stephen K. , Bhikadiya Charmi , Bi Chunxiao , Bittrich Sebastian , Chao Henry , Chen Li , Craig Paul A. , Crichlow Gregg V. , Dalenberg Kenneth , Duarte Jose M. , Dutta Shuchismita , Fayazi Maryam , Feng Zukang , Flatt Justin W. , Ganesan Sai J. , Ghosh Sutapa , Goodsell David S. , Green Rachel Kramer , Guranovic Vladimir , Henry Jeremy , Hudson Brian P. , Khokhriakov Igor , Lawson Catherine L. , Liang Yuhe , Lowe Robert , Peisach Ezra , Persikova Irina , Piehl Dennis W. , Rose Yana , Sali Andrej , Segura Joan , Sekharan Monica , Shao Chenghua , Vallat Brinda , Voigt Maria , Webb Benjamin , Westbrook John D. , Whetstone Shamara , Young Jasmine Y. , Zalevsky Arthur , Zardecki Christine 
Published: October 2022

AbstractNow in its 52nd year of continuous operations, the Protein Data Bank (PDB) is the premiere open‐access global archive housing three‐dimensional (3D) biomolecular structure data. It is jointly managed by the Worldwide Protein Data Bank (wwPDB) partnership. The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) is funded by the National Science Foundation, National Institutes of Health, and US Department of Energy and serves as the US data center for the wwPDB. RCSB PDB is also responsible for the security of PDB data in its role as wwPDB‐designated Archive Keeper. Every year, RCSB PDB serves tens of thousands of depositors of 3D macromolecular structure data (coming from macromolecular crystallography, nuclear magnetic resonance spectroscopy, electron microscopy, and micro‐electron diffraction). The RCSB PDB research‐focused web portal (RCSB.org) makes PDB data available at no charge and without usage restrictions to many millions of PDB data consumers around the world. The RCSB PDB training, outreach, and education web portal (PDB101.RCSB.org) serves nearly 700 K educators, students, and members of the public worldwide. This invited Tools Issue contribution describes how RCSB PDB (i) is organized; (ii) works with wwPDB partners to process new depositions; (iii) serves as the wwPDB‐designated Archive Keeper; (iv) enables exploration and 3D visualization of PDB data via RCSB.org; and (v) supports training, outreach, and education via PDB101.RCSB.org. New tools and features at RCSB.org are presented using examples drawn from high‐resolution structural studies of proteins relevant to treatment of human cancers by targeting immune checkpoints.
Relativistic Krori‐Barua Compact Stars in f(R,T)$f(R,T)$ Gravity
Authors: Shamir M. Farasat , Asghar Zoya , Malik Adnan 
Published: October 2022

AbstractThis work aims to investigate the behaviour of compact stars in the background of theory of gravity. For current work, we consider the Krori‐Barua metric potential i.e., and , where, and C are constants. We use matching conditions of spherically symmetric space‐time with Schwarzschild solution as an exterior geometry and examine the physical behaviour of stellar structure by assuming the exponential type gravity model. In the present analysis, we discuss the graphical behaviour of energy density, radial pressure, tangential pressure, equation of state parameters, anisotropy and stability analysis respectively. Furthermore, an equilibrium condition can be visualized through the modified Tolman‐Oppenheimer‐Volkov equation. Some extra features of compact stars i.e. mass‐radius function, compactness factor and surface redshift have also been investigated. Conclusively, all the results in current study validate the existence of compact stars under exponential gravity model.
Mass Hierarchies and Quantum Gravity Constraints in DKMM‐refined KKLT
Authors: Blumenhagen Ralph , Gligovic Aleksandar , Kaddachi Seyf 
Published: October 2022

AbstractWe carefully revisit the mass hierarchies for the KKLT scenario with an uplift term from an anti D3‐brane in a strongly warped throat. First, we derive the bound resulting from what is usually termed “the throat fitting into the bulk” directly from the Klebanov‐Strassler geometry. Generating the small value of the superpotential W0 via the mechanism proposed by Demirtas, Kim, McAllister and Moritz (DKMM), we identify two possible DKMM‐refined KKLT scenarios for stabilizing the light axio‐dilaton modulus. The first scenario spoils the expected hierarchy between the bulk and the throat mass scales and implies that the energy scale of the uplift is larger than the species scale of the effective theory in the throat. Moreover it requires an unnaturally large tadpole that is certainly in conflict with tadpole cancellation. For the less restricted second scenario, the hierarchy can be controlled at the expense of, under the most optimistic assumptions, an only moderately large tadpole .
Juglone promotes antitumor activity against prostate cancer via suppressing glycolysis and oxidative phosphorylation
Authors: Hu Cheng , Xu Haiyue , Li Zehao , Liu Dandan , Zhang Siqi , Fang Fang , Wang Liguo 
Published: October 2022

AbstractThe treatments currently used for prostate cancer (PC) do not meet clinical needs, and thus, new therapies with greater effectiveness are urgently required. Metabolic reprogramming of tumor cells is emerging as an exciting field for cancer therapy. Although the Warburg effect is a common feature of glucose metabolism in many cancers, PC cells have a unique metabolic phenotype. Non‐neoplastic prostate cells show reduced oxidative phosphorylation (OXPHOS) because large, accumulated zinc inhibits citrate oxidation. During transformation, there are low levels of zinc in PC cells, and the tricarboxylic acid (TCA) cycle is reactivated. However, metastatic PC exhibits the Warburg effect. Due to metabolic differences in prostate tissue, targeting metabolic alterations in PC cells is an attractive therapeutic strategy. In this study, we investigated the effect of juglone on energy metabolism in PC cells. We found that juglone inhibited cell proliferation and induced apoptosis. Mechanistically, we demonstrated that juglone suppressed OXPHOS and glycolysis due to its inhibition of hexokinase (HK), phosphofructokinase (PFK), and pyruvate kinase (PK) activity. Furthermore, downregulation of PFK and PK, but not HK contributed to the inhibition of these enzyme activities. The current study indicates that further development of juglone for PC treatment would be beneficial.
Improved off‐policy reinforcement learning algorithm for robust control of unmodeled nonlinear system with asymmetric state constraints
Authors: Zhang Yong , Mu Chaoxu , Feng Yanghe , Zhao Zhijia 
Published: October 2022

AbstractIn this article, an improved data‐based off‐policy reinforcement learning algorithm is proposed for the robust control of unmodeled nonlinear systems with asymmetric state constraints. An improved nonlinear mapping is defined for the asymmetric state constraint problem, which can ensure that the mapping state has better response speed and amplitude than the original state. Then, an auxiliary mapping error system is constructed for the off‐policy robust controller design. At the same time, an innovative network dimensionality reduction method based on principal component analysis is proposed to simplify the useless activation function of action network in off‐policy algorithm, which can effectively reduce the computational burden of data episodes. Considering the uncertain data caused by disturbances, a dominant data sampling method is designed to extract samples that are beneficial to algorithm convergence. On this basis, the improved off‐policy robust control algorithm is constructed. Based on an industrial manipulator system, the effectiveness of the dominant data sampling method and the improved off‐policy robust control algorithm is verified by comparative simulation.
Free water derived by multi‐shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease
Authors: Nakaya Moto , Sato Noriko , Matsuda Hiroshi , Maikusa Norihide , Shigemoto Yoko , Sone Daichi , Yamao Tensho , Ogawa Masayo , Kimura Yukio , Chiba Emiko , Ohnishi Masahiro , Kato Koichi , Okita Kyoji , Tsukamoto Tadashi , Yokoi Yuma , Sakata Masuhiro , Abe Osamu 
Published: October 2022

AbstractIntroductionFree‐water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau/inflammatory and amyloid positron emission tomography (PET).MethodsSeventy‐one participants underwent multi‐shell diffusion MRI, 18F‐THK5351 PET, 11C‐Pittsburgh compound B PET, and neuropsychological assessments. They were categorized into two groups: healthy controls (HCs) (n = 40) and AD‐spectrum group (AD‐S) (n = 31) using the Centiloid scale with amyloid PET and cognitive function. We analyzed group comparisons in FW and PET, correlations between FW and PET, and correlation analysis with neuropsychological scores.ResultsIn AD‐S group, there was a significant positive correlation between FW and 18F‐THK5351 in the temporal lobes. In addition, there were negative correlations between FW and cognitive function in the temporal lobe and cingulate gyrus, and negative correlations between 18F‐THK5351 and cognitive function in the same regions.DiscussionFW imaging could be a biomarker for tau in AD alongside clinical correlations.
miR‐1246 is implicated as a possible candidate for endometrium remodelling facilitating implantation in buffalo (Bubalus bubalis)
Authors: Dubey Pratiksha , Batra Vipul , Sarwalia Parul , Nayak Samiksha , Baithalu Rubina , Kumar Rakesh , Datta Tirtha Kumar 
Published: October 2022

AbstractBackgroundThe microRNAs (miRs) secreted by the trophectoderm (TE) cells have recently been implicated in the conceptus‐endometrial cross talk during implantation and placentation. These miRs modulate various cellular processes during conception and throughout the pregnancy by regulating the gene expression in the foetal and maternal tissues.ObjectivesThis study was undertaken to elucidate the function of TE secreted miRNAs in the maternal‐foetal cross‐talk during implantation/placentation in buffalo.MethodsThe in vitro produced blastocysts were cultured on a cumulus feeder layer for 21 days. The relative expression profiles of a selected panel of miRs was generated using the spent media collected on Days 0, 7, 12, 16, and 21. A custom‐designed mirVana™ miRNA mimic was used to transfect the endometrial epithelial cells (EECs) in order to determine the role of miRNA exhibiting highest expression on Days 21 and 21.ResultsThe expression of miR‐1246 (p < 0.001) and let‐7b (p < 0.01) was found to be significantly higher on Day 21 of TE culture in comparison to the control (Day 0). This elevated expression indicated the involvement of these miRs in the maternal‐foetal cross‐talk. Interestingly, after the transfection of EECs with miRNA mimic for miR‐1246 (a novel molecule vis‐à‐vis implantation), the expression of beta‐catenin and mucin1 in these cells was found to be significantly (p < 0.05) downregulated vis‐à‐vis the control, that is, the IFN‐τ primed EECs (before transfection).ConclusionsThe TE secreted miR‐1246 appeared to lower the expression of the endometrial receptivity genes (mucin1 and beta‐catenin) which apparently assists the endometrium in preparing for placentation.
Non-relativistic and ultra-relativistic expansions of three-dimensional spin-3 gravity theories
Authors: Concha Patrick , Henríquez-Baez Carla , Rodríguez Evelyn 
Published: October 2022

Abstract
In this paper, we present novel and known non-relativistic and ultra-relativistic spin-3 algebras, by considering the Lie algebra expansion method. We start by applying the expansion procedure using different semigroups to the spin-3 extension of the AdS algebra, leading to spin-3 extensions of known non-relativistic and ultra-relativistic algebras. We then generalize the procedure considering an infinite-dimensional semigroup, which allows to obtain a spin-3 extension of two new infinite families of the Newton-Hooke type and AdS Carroll type. We also present the construction of the gravity theories based on the aforementioned algebras. In particular, the expansion method based on semigroups also allows to derive the (non-degenerate) invariant bilinear forms, ensuring the proper construction of the Chern-Simons gravity actions. Interestingly, in the vanishing cosmological constant limit we recover the spin-3 extensions of the infinite-dimensional Galilean and infinite-dimensional Carroll gravity theories.
Basal Gp78-dependent mitophagy promotes mitochondrial health and limits mitochondrial ROS
Authors: Alan Parsa , Vandevoorde Kurt R. , Joshi Bharat , Cardoen Ben , Gao Guang , Mohammadzadeh Yahya , Hamarneh Ghassan , Nabi Ivan R. 
Published: October 2022

AbstractMitochondria are major sources of cytotoxic reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, that when uncontrolled contribute to cancer progression. Maintaining a finely tuned, healthy mitochondrial population is essential for cellular homeostasis and survival. Mitophagy, the selective elimination of mitochondria by autophagy, monitors and maintains mitochondrial health and integrity, eliminating damaged ROS-producing mitochondria. However, mechanisms underlying mitophagic control of mitochondrial homeostasis under basal conditions remain poorly understood. E3 ubiquitin ligase Gp78 is an endoplasmic reticulum membrane protein that induces mitochondrial fission and mitophagy of depolarized mitochondria. Here, we report that CRISPR/Cas9 knockout of Gp78 in HT-1080 fibrosarcoma cells increased mitochondrial volume, elevated ROS production and rendered cells resistant to carbonyl cyanide m-chlorophenyl hydrazone (CCCP)-induced mitophagy. These effects were phenocopied by knockdown of the essential autophagy protein ATG5 in wild-type HT-1080 cells. Use of the mito-Keima mitophagy probe confirmed that Gp78 promoted both basal and damage-induced mitophagy. Application of a spot detection algorithm (SPECHT) to GFP-mRFP tandem fluorescent-tagged LC3 (tfLC3)-positive autophagosomes reported elevated autophagosomal maturation in wild-type HT-1080 cells relative to Gp78 knockout cells, predominantly in proximity to mitochondria. Mitophagy inhibition by either Gp78 knockout or ATG5 knockdown reduced mitochondrial potential and increased mitochondrial ROS. Live cell analysis of tfLC3 in HT-1080 cells showed the preferential association of autophagosomes with mitochondria of reduced potential. Xenograft tumors of HT-1080 knockout cells show increased labeling for mitochondria and the cell proliferation marker Ki67 and reduced labeling for the TUNEL cell death reporter. Basal Gp78-dependent mitophagic flux is, therefore, selectively associated with reduced potential mitochondria promoting maintenance of a healthy mitochondrial population, limiting ROS production and tumor cell proliferation.
Bibliometric development of Naunyn–Schmiedeberg’s Archives of Pharmacology
Authors: Dats Leah B. , von Haugwitz Florentin , Seifert Roland 
Published: October 2022

AbstractMotivated by the 150-year anniversary of the Naunyn–Schmiedeberg’s Archives of Pharmacology in 2023, we studied the bibliometric development of the journal. We evaluated data from Editorial Reports, Clarivate, and Springer Nature databases. Several parameters representing the journal’s performance, such as the impact factor and social impact, were analyzed over the years. We analyzed the journal’s meta-data and wrote an algorithm to retrieve cities and countries of origin. We could see a decrease in publications from Germany and an increase in papers from Brazil, China, Egypt, and Iran during the last years. The decrease in publications from Germany is probably a zeitgeist effect because this country places a strong emphasis on high-impact factor papers for academic promotion and winning grants. Germany was the country with the most publications throughout the 100 most-cited articles. Most of these articles were published between 1970 and 1990, when neurotransmitters were the most published topic. Klaus Starke (Freiburg) and Manfred Göthert (Bonn) were prominent drivers of this field. The most common topics nowadays are “Drugs for the Treatment of Malignant Tumor Diseases” and “Immunopharmacology.” The internationality of the journal substantially increased after introduction of English as mandatory language in the 1970s. The journal also experienced substantial COVID-19 pandemic-related effects. This paper is not only of relevance for the field of pharmacology but for science in general in the sense that Naunyn–Schmiedeberg’s Archives of Pharmacology is a case study for profound changes in a traditional scientific journal, requiring permanent adjustment by editors, referees, publisher, authors, and readers alike. The development of the journal has been strongly influenced by historic and political developments, cultural attitudes (zeitgeist), language changes, global changes in research topics, and eminent individuals who published many papers in Naunyn–Schmiedeberg’s Archives of Pharmacology.
Production of propionate using metabolically engineered strains of Clostridium saccharoperbutylacetonicum
Authors: Baur Tina , Wentzel Alexander , Dürre Peter 
Published: October 2022

Abstract
The carboxylic acid propionate is a valuable platform chemical with applications in various fields. The biological production of this acid has become of great interest as it can be considered a sustainable alternative to petrochemical synthesis. In this work, Clostridium saccharoperbutylacetonicum was metabolically engineered to produce propionate via the acrylate pathway. In total, the established synthetic pathway comprised eight genes encoding the enzymes catalyzing the conversion of pyruvate to propionate. These included the propionate CoA-transferase, the lactoyl-CoA dehydratase, and the acryloyl-CoA reductase from Anaerotignum neopropionicum as well as a D-lactate dehydrogenase from Leuconostoc mesenteroides subsp. mesenteroides. Due to difficulties in assembling all genes on one plasmid under the control of standard promoters, the PtcdB-tcdR promoter system from Clostridium difficile was integrated into a two-plasmid system carrying the acrylate pathway genes. Several promoters were analyzed for their activity in C. saccharoperbutylacetonicum using the fluorescence-activating and absorption-shifting tag (FAST) as a fluorescent reporter to identify suitable candidates to drive tcdR expression. After selecting the lactose-inducible PbgaL promoter, engineered C. saccharoperbutylacetonicum strains produced 0.7 mM propionate upon induction of gene expression. The low productivity was suspected to be a consequence of a metabolic imbalance leading to acryloyl-CoA accumulation in the cells. To even out the proposed imbalance, the propionate-synthesis operons were rearranged, thereby increasing the propionate concentration by almost four-fold. This study is the first one to report recombinant propionate production using a clostridial host strain that has opened a new path towards bio-based propionate to be improved further in subsequent work.

Key points
• Determination of promoter activities in C. saccharoperbutylacetonicum using FAST.
• Implementation of propionate production in C. saccharoperbutylacetonicum.
• Elevation of propionate production by 375% to a concentration of 3 mM.