bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic Profile and Echocardiographic Evaluation in Adults with Growth Hormone Deficiency
Authors: Yang Hongbo , Xu Hanyuan , Wang Linjie , Duan Lian , Gong Fengying , Zhu Huijuan , Pan Hui 
Published: October 2022

AbstractAdult growth hormone deficiency (AGHD) is associated with increased cardiovascular risks. The primary endpoint of this retrospective cohort study was to compare metabolic profile and echocardiographic parameters in childhood-onset (CO) and adulthood-onset (AO) AGHD patients. 26 patients with CO AGHD (19 males, 26.8±8.5 years) and 41 patients with AO AGHD (23 males, 35.1±6.8 years) were included. The standard deviation score of insulin-like growth factor-1 (IGF-1 SDS), metabolic profile, liver sonography and echocardiographic parameters were compared. The IGF-1 SDS were significantly lower in CO AGHD patients (p<0.05). AO AGHD patients showed much profound glycolipid aberrations, elevated C-reactive protein levels (p=0.012), and proportionally higher prevalence of non-alcoholic fatty liver disease (95.2% vs.8.3%, p<0.001). In all subjects, IGF-1 SDS was negatively related to low-density lipoprotein cholesterol, and positively related to total cholesterol and lipoprotein a (Lpa). There were significant differences between the two group with regard to the correlations between IGF-1 SDS and high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, LPa, uric acid and creatinine (all p for interaction<0.05). CO AGHD patients exhibited smaller heart, but similar ventricular ejection fraction compared to AO AGHD patients. AGHD may be a group of heterogenous entity based on the onset ages of disease. AO patients had prominent metabolic disorders, while CO patients had smaller heart but similar cardiac performance. Whether growth hormone replacement therapy will equally benefit both CO and AO AGHD patients needs further investigations.
Unmet medical need in der Hals-Nasen-Ohren-Heilkunde: Die HNO-Ärztinnen und HNO-Ärzte sind gefordert
Authors: Guntinas-Lichius Orlando , Deitmer Thomas , Löhler Jan , Bujok Oliver 
Published: October 2022

Zusammenfassung
Hintergrund HNO-Ärztinnen und HNO-Ärzte sind prädestiniert dafür, den medizinischen Bedarf in der HNO-Heilkunde unter dem Dach der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie (DGHNO-KHC) wissenschaftlich zu analysieren und zu priorisieren. Diese Bedarfsanalyse ist wichtig, um gezielt Erforschung und Entwicklung medizinischer Innovationen zur besseren Versorgung von HNO-Patientinnen und HNO-Patienten auf diesen Bedarf auszurichten und entsprechende Programme zur Forschungs- und Innovationsförderung frühzeitig anzustoßen.
Methoden Hiermit soll die Empfehlung ausgesprochen werden, dass die DGHNO-KHC und deren Arbeitsgemeinschaften und Arbeitsgruppen in ihren Spezialdisziplinen sich des Themas annehmen. Das Ziel ist ein umfassendes Medical Need Assessment für die HNO-Heilkunde. Die Kriterien zur Parametrisierung des medizinischen Bedarfs werden dem Konzept des unmet medical need (UMN) entnommen. Zur Priorisierung von UMN wird die Methode der multikriteriellen Entscheidungsanalyse (Multi-criteria decision analysis; MCDA) herangezogen.
Empfehlung Die Arbeitsgemeinschaften und Arbeitsgruppen der DGHNO-KHC machen sich mit dem Konzept des UMN vertraut. Anschließend werden Vorschläge zu HNO-Erkrankungen mit UMN in Diagnostik und Therapie unter Beachtung der medizinischen Evidenz gesammelt. Die Vorschläge werden nach MCDA standardisiert bewertet und ein Ranking aufgestellt. Die Ergebnisse werden veröffentlicht und genutzt, um Institutionen der Forschungs- und Innovationsförderung auf den UMN in der HNO-Heilkunde aufmerksam zu machen.
Diskussion Die Arbeit wird zur Weiterentwicklung des UMN-Konzepts beitragen und auch eine Grundlage schaffen können, um das Instrument des Medical Need Assessment in Deutschland zu etablieren. Die DGHNO-KHC wird über diese Arbeit als wichtiger wissenschaftlicher Motor für die Entwicklung bedarfsgetriebener medizinischer Innovationen in Deutschland wahrgenommen.
Technology Acceptance of a Mobile Application to Support Family Caregivers in a Long-Term Care Facility
Authors: Perez Hector , Miguel-Cruz Antonio , Daum Christine , Comeau Aidan K. , Rutledge Emily , King Sharla , Liu Lili 
Published: October 2022

Abstract
Background Family caregivers are unpaid individuals who provide care to people with chronic conditions or disabilities. Family caregivers generally do not have formal care-related training. However, they are an essential source of care. Mobile technologies can benefit family caregivers by strengthening communication with care staff and supporting the monitoring of care recipients.
Objective We conducted a mixed-method study to evaluate the acceptance and usability of a mobile technology called the Smart Care System.
Methods Using convenience sampling, we recruited 27 family caregivers to evaluate the mobile Smart Care System (mSCS). In the quantitative phase, we administered initial and exit questionnaires based on the Unified Theory of Acceptance and Use of Technology. In the qualitative phase, we conducted focus groups to explore family caregivers' perspectives and opinions on the usability of the mSCS. With the quantitative data, we employed univariate, bivariate, and partial least squares analyses, and we used content analysis with the qualitative data.
Results We observed a high level of comfort using digital technologies among participants. On average, participants were caregivers for an average of 6.08 years (standard deviation [SD] = 6.63), and their mean age was 56.65 years (SD = 11.62). We observed a high level of technology acceptance among family caregivers (7.69, SD = 2.11). Behavioral intention (β = 0.509, p-value = 0.004) and facilitating conditions (β = 0.310, p-value = 0.049) were statistically significant and related to usage behavior. In terms of qualitative results, participants reported that the mobile application supported care coordination and communication with staff and provided peace of mind to family caregivers.
Conclusion The technology showed high technology acceptance and intention to use among family caregivers in a long-term care setting. Facilitating conditions influenced acceptance. Therefore, it would be important to identify and optimize these conditions to ensure technology uptake.
End-to-Side Nerve Transfer for the Management of Chronic Leg Compartment Ankle Dorsiflexion Weakness
Authors: Rodriguez-Collazo Edgardo R. , Raja Asim A.Z. , Ward Shawn Christopher , Oexeman Stephanie , Khan Arshad A. 
Published: October 2022

Abstract
Background A proximal deep peroneal nerve (DPN) injury can significantly impact the functional capacity of the leg, to include compromised motor function of the tibialis anterior (TA) muscle. Clinical examination can range from weakness in ankle dorsiflexion, to complete foot drop. Diagnostic nerve conduction velocity (NCV) testing can demonstrate abnormalities at select areas of impingement (or) entrapment (i.e., regions affected by a demyelinating compression mono-neuropathy), along the proximal course of the common peroneal nerve.
Methods We retrospectively report on 17 patients with clinical weakness involving ankle dorsiflexion. All patients underwent surgical end-to-side anastomosis, transferring a muscular nerve branch from the superficial peroneal nerve (SPN) to a segment of the DPN responsible for TA muscle innervation. Outcomes were based on comparisons of preoperative and postoperative DPN motor function to the TA muscle, standardized to the British Medical Research Council Scale for Muscle Strength. Preoperative scores were generally M2 or below.
Results Postoperative outcome scores of M4 to M5 were considered good (or) successful. 94.1% of patients demonstrated successful outcomes.
Conclusion An end-to-side SPN motor branch anastomosis, into the motor branch of the DPN responsible for TA muscle innervation, can be a viable treatment option for weakness in ankle dorsiflexion. All reported cases involved a compromised segment of deep peroneal nerve within the proximal one-third of the leg.
Critical View of Safety in Laparoscopic Cholecystectomy: A Word of Caution in Cases of Aberrant Anatomy
Authors: Antonopoulou Maria Ioanna , Manatakis Dimitrios K. 
Published: October 2022

Abstract
Introduction To avoid vasculobiliary injuries, the Critical View of Safety (CVS) technique is strongly recommended during dissection of the hepatocystic triangle. It entails three basic steps as follows: (1) complete clearance of the hepatocystic triangle of fibrofatty tissue, (2) separation of the lower part of the gallbladder from the cystic plate, so that (3) two and only two structures are seen entering the gallbladder.
Case History In this video vignette, we present the case of an aberrant hepatic artery, coursing subserosally parallel to the gallbladder wall. Despite presumably achieving all three CVS requirements, the surgeon did not proceed to clipping and dividing the two structures, preventing a major vascular injury. Due to its unusually large caliber, the artery was carefully dissected, and multiple smaller branches to the gallbladder were ligated instead, until it was definitively identified entering into the hepatic parenchyma of segments IVb–V.
Discussion The CVS approach was originally conceived as a means for the conclusive recognition of the cystic duct and artery to prevent misidentification errors. However, in such cases of extreme anatomical variations, the CVS may indeed have certain limitations. Therefore the surgeon should always maintain a high degree of suspicion and a low threshold for alternative bail-out options.
O uso do escore SARC-F como auxiliar na prevenção de fraturas por fragilidade
Authors: Martini Carlos Augusto Nunes , Weigert Carolina Souza , Stiegemaier Anderson Carlos Bigolin , Ferreira Ana Paula Ribeiro Bonilauri , Gonçalves Ellen Liceras , Valle Sandro Fortes 
Published: October 2022

Resumo
Objetivo O presente estudo teve como objetivo relacionar o escore strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC-F) com a presença ou não de fratura por fragilidade na população acima de 60 anos.
Métodos O risco de sarcopenia foi determinado por meio da aplicação do questionário SARC-F, sendo os pacientes divididos em 2 grupos, de acordo com a ocorrência ou não de fratura por fragilidade (n = 100).
Resultados Foram levantados 32 casos de fratura de rádio distal e 18 casos de fratura de fêmur proximal. Uma maior pontuação no SARC-F determina bem entre ter ou não ter fratura por fragilidade, estimando que a cada ponto a mais no escore há um acréscimo de 70% na chance de o paciente ter fratura, independentemente da idade, sexo e índice de massa corporal (IMC).
Conclusão Houve correlação direta entre uma maior pontuação no SARC-F e aumento na chance de fratura por fragilidade.
Multiple Primary Bilateral Cerebral Echinococcosis in an Adult: A Neurological Rarity
Authors: Garg Manish , Sarma Pragyan , Chaturvedi Sujata , Pant Ishita 
Published: October 2022

AbstractAlthough cases of intracranial hydatid cysts are commonly encountered, majority of them are secondary and are seen in children. Primary bilateral multiple intracranial hydatid cysts in adults are a neurological rarity. Intracranial involvement usually occurs following infestation of the other organs in the body by the pathogen. Multiple lesions in brain can manifest either following rupture of a single parent cyst in brain or by systemic dissemination from other organs. Here, we are presenting an adult patient who underwent successful surgical removal of multiple primary hydatid cysts of brain. A 47-year-old male patient presented with features of raised intracranial pressure and other focal deficits. Magnetic resonance imaging showed multiple cystic lesions on both sides of the cerebrum. Similar primary lesions elsewhere in the body were ruled out by other investigations. He underwent successful surgical removal of all the lesions. Intraoperative picture and histology were suggestive of hydatid cyst. In published literature, there are very few cases similar to ours. Echinococcosis should be considered as a differential diagnosis in multiple cystic lesions of the brain in endemic areas. Early diagnosis, proper surgical technique, and standard antihelminthic drug regimen are the key to achieve good outcome in these patients.
Pediatric Cervical Spine Injuries
Authors: Yadav Awdhesh , Singh Aneeta , Verma Rajat , Singh Vijay K. , Ojha Bal K. , Chandra Anil , Srivastava Chhitij 
Published: October 2022

Abstract
Objective Pediatric cervical spine injuries are rare and account for 1 to 2% of all pediatric spine injuries. There is a paucity of data on pediatric cervical spine injuries in developing countries like India. The purpose of this study is to review and analyze our 5 years of experience with pediatric cervical spine injuries.
Methods All the available medical records over the 5 years were reviewed retrospectively. The data was analyzed to know the epidemiology, mechanism of injury, injury patterns, management, and outcome. The patients were divided into two groups: 0 to 9 years and 10 to 18 years.
Results Seventy-five eligible records were included in our study. The incidence of cervical spine injuries was significantly lower in younger children than the older ones (p < 0.042). The most common mechanism of injury was fall from height: 33 (44%) patients followed by road traffic accidents: 27 (36%) patients. The involvement of the upper cervical spine was significantly higher in younger children (p < 0.001). Fractures with subluxation were the most common pattern of injury, observed in 35 (47%) patients. However, fractures with subluxation were uncommon in younger children compared with older children (p < 0.04). Spinal cord injury without radiographic abnormality (SCIWORA) was observed in 42% of younger children compared with 8% of older children (p < 0.02). Thirty (40%) patients were managed surgically; anterior cervical corpectomy with fusion was the most commonly performed procedure in 19 (63%) patients. The overall mortality was 20%.
Conclusion The results of our study revealed predominant involvement of the upper cervical spine in children younger than 10 years of age. SCIWORA was documented in both the age groups with a significantly higher incidence in younger children. The instrumentation and fusion techniques in children are safe; however, developing pediatric spine needs special considerations.
Joint experimental and theoretical study on electron scattering from titanium tetrachloride (TiCl4) molecule
Authors: Tańska Natalia , Randi Pedro A. S. , Stefanowska-Tur Sylwia , Moreira Giseli M. , Ptasińska-Denga Elżbieta , Bettega Márcio H. F. , Szmytkowski Czesław , Możejko Paweł 
Published: October 2022

Absolute grand-total cross section for electron scattering from titanium tetrachloride, TiCl4, molecule was measured at electron-impact energies ranging from 0.3 to 300 eV, in the linear electron-transmission experiment. The elastic integral, differential, momentum transfer, and total ionization cross sections for TiCl4 molecule were also calculated for low and intermediate collisional energies at the level of various theories. The low-energy elastic integral, differential, and momentum transfer cross sections were calculated with the Schwinger multichannel method implemented with pseudopotentials, in the static-exchange and static-exchange plus polarization levels of approximation, for energies up to 30 eV. The integral cross section calculated for low-energy electron scattering with the R-matrix method within the static-exchange and static-exchange plus polarization approximations for energies up to 15 eV are also reported. By the inspection of the cross sections, the presence of resonances is discussed. In particular, the calculated integral cross sections and the measured total cross section display a minimum at around 1 eV, which is consistent with the presence of a Ramsauer–Townsend minimum and a sharp increase at low energies, which is consistent with the presence of a virtual state. Additionally, interactions in elastic and ionization channels for intermediate collision energies were investigated with the additivity rule and the binary-encounter-Bethe methods.
Influence of calcium on the toxicity of saline solutions to the mayfly,
Authors: Nanjappa Vinitha , Vink Sue , Dunlop Jason , Krosch Matt N. , Mann Reinier 
Published: October 2022

Context Although calcium may provide a means to reduce toxicity of saline waters, the relationship between them is not well understood. Aim To investigate whether increasing calcium may result in a proportional reduction in toxicity. Methods Acute toxicity tests were conducted using an artificial mine-affected water (AMW) and the same AMW with increased calcium on the mayfly species, Austrophlebioides sp. AV11. Results Results demonstrated that there was a reduction in toxicity when calcium concentration (added as both calcium chloride and calcium sulfate together) was increased by both two-fold (+143 mg L−1) and four-fold (+272 mg L−1) compared with the AMW test solution (161 mg L−1). A further increase by up to eight-fold (+718 mg L−1) did not substantially change the toxicity of the AMW solution. Conclusion The toxicity did not reduce when calcium chloride and calcium sulfate salts were used independently. This study suggests that adding calcium (as calcium chloride and calcium sulfate) to a saline solution reduces toxicity upto a maximum threshold, beyond which no further benefit is achieved. Implications Increased calcium can have diminishing effect on toxicity or reach a maximum threshold beyond which no further reduction in toxicity is achieved. Improved understanding of this relationship is needed to inform the management of saline mine waters.
Controlling inversion disorder in a stoichiometric spinel magnet
Authors: Dronova Margarita G. , Ye Feng , Cooper Scott E. , Krishnadas Anjana , Hoffmann Christina M. , Fujisawa Yuita , Okada Yoshinori , Khomskii Daniel I. , Feng Yejun 
Published: October 2022

In the study of frustrated quantum magnets, it is essential to be able to control the nature and degree of site disorder during the growth process, as many measurement techniques are incapable of distinguishing between site disorder and frustration-induced spin disorder. Pyrochlore-structured spinel oxides can serve as model systems of geometrically frustrated three-dimensional quantum magnets; however, the nature of the magnetism in one well-studied spinel, ZnFe
2
O
4
, remains unclear. Here, we demonstrate simultaneous control of both stoichiometry and inversion disorder in the growth of ZnFe
2
O
4
single crystals, directly yielding a revised understanding of both the collective spin behavior and lattice symmetry. Crystals grown in the stoichiometric limit with minimal site inversion disorder contravene all the previously suggested exotic spin phases in ZnFe
2
O
4
. Furthermore, the structure is confirmed on the

F

4
¯

3
m

space group with broken inversion symmetry that induces antiferroelectricity. The effective tuning of magnetic behavior by site disorder in the presence of robust antiferroelectricity makes ZnFe
2
O
4
of special interest to multiferroic devices.
Space-borne atom interferometric gravitational wave detections. Part III. Eccentricity on dark sirens
Authors: Yang Tao , Cai Rong-Gen , Lee Hyung Mok 
Published: October 2022

AbstractEccentricity of the inspiraling compact binaries can greatly improve the distance inference and source localization of dark sirens. In this paper, we continue the research for the space-borne atom interferometric gravitational-wave detector AEDGE and investigate the effects of eccentricity on the dark sirens observed by AEDGE in the mid-band. We simulate five types of typical compact binaries with component mass ranging from 1-100 M⊙. The largest improvement for both distance inference and localization can be as much as 1.5–3 orders of magnitude. We then construct the catalogs of dark sirens observed by AEDGE in five years. We find eccentricity is crucial to the detection of golden binary black holes (BBH) whose host galaxy can be uniquely identified. With only 5–10 golden dark BBHs one can obtain a 2 percent precision measurement ofH0which is sufficient to arbitrate the Hubble tension. Regardless of eccentricity, AEDGE can also observe tens of golden binary neutron stars (BNS) and neutron star-black hole binaries (NSBH) with unique host galaxies. These golden dark sirens can serve as early warnings for the follow-up observations of gravitational waves in the high frequency band as well as the search of their electromagnetic counterparts. Our results show eccentricity is a crucial factor in the detection, data analysis, and application of GWs with the atom interferometers in the mid-band.
Energetic particle loss mechanisms in reactor-scale equilibria close to quasisymmetry
Authors: Paul E.J. , Bhattacharjee A. , Landreman M. , Alex D. , Velasco J.L. , Nies R. 
Published: October 2022

Abstract
Collisionless physics primarily determines the transport of fusion-born alpha particles in 3D equilibria. Several transport mechanisms have been implicated in stellarator configurations, including stochastic diffusion due to class transitions, ripple trapping, and banana drift-convective orbits. Given the guiding center dynamics in a set of six quasihelical and quasiaxisymmetric equilibria, we perform a classification of trapping states and transport mechanisms. In addition to banana drift convection and ripple transport, we observe substantial non-conservation of the parallel adiabatic invariant which can cause losses through diffusive banana tip motion. Furthermore, many lost trajectories undergo transitions between trapping classes on longer time scales, either with periodic or irregular behavior. We discuss possible optimization strategies for each of the relevant transport mechanisms. We perform a comparison between fast ion losses and metrics for the prevalence of mechanisms such as banana-drift convection (Velasco et al 2021 Nucl. Fusion
61 116059), transitioning orbits, and wide orbit widths. Quasihelical configurations are found to have natural protection against ripple-trapping and diffusive banana tip motion leading to a reduction in prompt losses.
Exergoeconomic analysis of potential magnet configurations of a magnetic refrigerator operating at 4.2 K
Authors: López de Toledo C.H. , López J.M. , Rodriguez L.G.-T. 
Published: October 2022

Abstract
This article compares the exergetic cost of cooling of an Adiabatic Demagnetization Refrigerator (ADR) providing 1 W of refrigeration at 4.2 K, with two different magnetic field sources: a Nb3Sn superconducting (SC) magnet and a NdFeB permanent magnet (PM) Halbach cylinder. The total cost of the system is assumed to be comprised of two components: the cost of the magnetocaloric material (MCM), which is a function of the total volume of the MCM, and the cost of the magnetic system, which depends on the MCM volume and the peak magnetic field. The exergetic cost of cooling for different values of mass (volume) of MCM and hot source temperatures are shown in the article, assuming a specific cost of the SC wire of 890$/kg, 3500$/kg for the MCM, and 100$/kg for the PM. The SC appear to be the most cost-effective solution for the system. However, if large temperatures spans are required between the hot source and the cold source PMs emerge as a better option.