bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of COVID-19 in Hemodialysis Patients Using Traditional Chinese Medicine: A Single-Center, Retrospective Study
Authors: Huang Wei , Jiang Bo , Luo Jinli , Luo Meng , Ding Xiaoming , Yang Qian , Zhao Lin-Hua , Sun Qin-Guo , Tong Xiao-Lin 
Published: March 2022

Background: To explore the effect of combining traditional Chinese medicine (TCM) and Western medicine in hemodialysis patients with coronavirus disease 2019 (COVID-19).Methods: This study was conducted from 27 January 2020 to 17 March 2020 in Wuhan Third Hospital Guanggu Branch, Wuhan, China. Fifty-three patients were included and divided into a control group (CG), which received Western medicine and a combined treatment group, which received TCM and Western medicine (TG). Clinical and laboratory data, TCM symptom scores, and chest computed tomography results were extracted and compared between the two groups.Results: The TG included 21 (67.7%) men and 10 (32.3%) women with a mean age of 61.02 (standard deviation [SD] 15.07, range 26–89) years. The mean dialysis duration in the TG was 49 (SD 31) months. Of all patients in the TG, 27 (87.1%) had fatigue, 18 (58.1%) had dry cough, 16 (51.6%) had anorexia, 11 (35.5%) had dyspnea, and 11 (35.5%) had fever. The CG included 14 (63.6%) men and 8 (36.4%) women with a mean age of 61.45 (SD 13.78, range 36–84) years. The mean dialysis duration in the CG was 63 (SD 46) months. Of all patients in the CG, 21 (95.5%) had fatigue, 12 (54.5%) had dry cough, 17 (77.3%) had anorexia, 12 (54.5%) had dyspnea, and 7 (31.8%) had fever. After treatment, the TCM symptom scores of the two groups decreased; the anorexia scores were lower in the TG than in the CG (p &lt; 0.05). After treatment, albumin increased and D-dimer, C-reactive protein, and lactate dehydrogenase levels decreased in the TG. The d-dimer levels were lower and the albumin level was higher in the TG than in the CG after treatment (p &lt; 0.05). The cure rate was higher, and the mortality rate was lower in the TG than in the CG (p &lt; 0.05).Conclusion: A combination of TCM and Western medicine in hemodialysis patients with COVID-19 could relieve symptoms and help recovery. Further evidence from larger randomized controlled trials is needed to confirm our results.
On the Parental Influence on Children’s Physical Activities and Mental Health During the COVID-19 Pandemic
Authors: Khozaei Fatemeh , Carbon Claus-Christian 
Published: March 2022

BackgroundWhile neighborhood safety and stranger danger have been mostly canonized to play a part in parents’ physical activity (PA) avoidance, less is known about the impact of parental stress and perceived risk on children’s PA avoidance and consequently on children’s level of PA and wellbeing. Understanding the contributors to children’s wellbeing during pandemic disease is the first critical step in contributing to children’s health during epidemic diseases.MethodsThis study employed 276 healthy children, aged 10–12 years, and their parents. Data were collected in October and November 2020, about 9 months after the local closing of schools due to the coronavirus disease 2019 (COVID-19) pandemic. Parents and children answered a separate set of questions. Besides the demographic information, the parents responded to questions on their stress level, perceived risk of COVID-19, and PA avoidance for children. Children responded to questions on their PA and wellbeing in the last week. Data were analyzed using SmartPLS and IBM SPSS 22.ResultsThe result of the study supported the four directional research hypotheses of the sequential study model. As hypothesized, parents’ stress and perceived risk levels of COVID-19 negatively affected children’s PA. The PA level was shown to predict children’s wellbeing and mental health. Housing type, parents’ job security, number of siblings, number of members living together in-home, and history of death or hospitalization of relatives or family members due to COVID-19 were found to be associated with parents’ stress and children’s mental health.ConclusionThis study sheds light on parents’ role in children’s wellbeing and mental health during the COVID-19 pandemic. Parents with higher stress and high restrictive behaviors might put their children at risk of mental disorders in the end.
Sero-Surveillance to Monitor the Trend of SARS-CoV-2 Infection Transmission in India: Study Protocol for a Multi Site, Community Based Longitudinal Cohort Study
Authors: Nair Divya , Raju Reshma , Roy Sudipto , Dandge Shailendra , Chethrapilly Purushothaman Girish Kumar , Jayaraman Yuvaraj , Kangusamy Boopathi , Shrivastava Rahul , Arora Narendra Kumar , Rose Winsley , Juvekar Sanjay , Jammy Guru Rajesh , Singh Kavita , Mehendale Sanjay , Rajkumar Prabu , Malik Shikha Taneja 
Published: March 2022

IntroductionLarge-scale sero-prevalence studies with representation from all age groups are required to estimate the true burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the community. Serial serological surveys in fixed cohorts enable study of dynamics of viral transmission and correlates of immune response over time in the context of gradual introduction of COVID-19 vaccines and repeated upsurge of cases during the pandemic.MethodsThis longitudinal study will involve follow-up of a cohort of 25,000 individuals (5,000 per site) aged 2 years and above recruited from five existing demographic surveillance sites in India. The cohort will be tested for the presence of IgG antibodies against S1/S2 spike protein subunits of SARS-CoV-2 in four rounds; once at baseline and subsequently, at intervals of 4 months for a year between January 2021 and January 2022. Neutralization assays will be carried out in a subset of seropositive samples in each round to quantify the antibody response and to estimate the durability of antibody response. Serial serological surveys will be complemented by fortnightly phone based syndromic surveillance to assess the burden of symptomatic acute febrile illness/ influenza like illness in the same cohort. A bio-repository will also be established to store the serum samples collected in all rounds of serological surveys.DiscussionThe population based sero-epidemiological studies will help to determine the burden of COVID-19 at the community level in urban and rural Indian populations and guide in monitoring the trends in the transmission of SARS-CoV-2 infection. Risk factors for infection will be identified to inform future control strategies. The serial serological surveys in the same set of participants will help determine the viral transmission dynamics and durability of neutralizing immune response in participants with or without symptomatic COVID infection.
Sleep Patterns and Myopia Among School-Aged Children in Singapore
Authors: Li Mijie , Tan Chuen-Seng , Xu Lingqian , Foo Li-Lian , Yap Fabian , Sun Chen-Hsin , Tham Elaine K. H. , Cai Shirong , Ang Marcus , Saw Seang-Mei , Sabanayagam Charumathi 
Published: March 2022

PurposeTo evaluate the associations of sleep factors with myopia, spherical equivalent (SE), and axial length (AL) in elementary school-aged children from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort.MethodsThis cross-sectional study included multi-ethnic children who participated in the GUSTO prospective birth cohort and were delivered in two major tertiary hospitals in Singapore (2009–2010). Sleep factors and myopia outcomes were assessed at the 8- and 9-year study visits, respectively. Parent-reported sleep quality was assessed with the Children's Sleep Habits Questionnaire (CSHQ) total scores. Additionally, each child's sleep duration, timing (bedtime; waketime), and the consistency of sleep duration or timing (i.e., the difference between weekends and weekdays) were parent-reported. Outcomes included cycloplegic SE, myopia (SE ≤ −0.5 D) and AL. Eye measurements from both eyes were included in the analyses. Multivariable linear or logistic regression with Generalized Estimating Equations were used to account for the correlation between paired eyes and confounders in the associations of sleep factors at age 8 and myopia at age 9.ResultsA total of 572 multi-ethnic children (49.5% boys; 56.1% Chinese) aged 9 years were included in the analyses. Overall, 37.3% of eyes were myopic. Children reported a mean total CSHQ score of 46 [standard deviation (SD) = 6]. The mean duration of sleep was 9.2 (SD= 1.0) hours per day (h/day), with 59.9% of children reporting sufficient sleep (≥9 h/day) based on guidelines recommended by the National Sleep Foundation, USA. The mean bedtime and wake time were 22:00 (SD= 00:53) and 07:08 (SD= 00:55), respectively. In multivariable regression models, total CSHQ scores, the duration of sleep, bedtime and wake time were not significantly associated with myopia, SE, or AL (p≥ 0.05 for all), adjusting for gender, ethnicity, time outdoors, near-work, parental myopia, maternal education levels (and additionally the child's height when the outcome was AL). Similarly, the consistency of both the duration and timing of sleep (across weekends and weekdays) were not significantly associated with myopia, SE, or AL (p≥ 0.05 for all).ConclusionIn this cross-sectional study, sleep quality, duration, timing, and the consistency of specific sleep factors were not independently associated with myopia, SE, or AL among elementary school-aged children in Singapore. Large longitudinal studies are warranted to corroborate these results.
Obstetric and Perinatal Complications in the Induction of Labor at Different Stages of Pregnancy
Authors: Васильев С.А. , Пересада О.А. , Курлович И.В. , Ващилина Т.П. , Семенчук В.Л. , Виктор С.А. 
Published: March 2022

Цель исследования: оценить вероятность развития акушерских и перинатальных осложнений при индуцированных родах в зависимости от срока беременности.Материалы и методы. Проведен ретроспективный анализ акушерских и перинатальных исходов по данным 850 историй родов (форма № 096/у) за 2015–2019 гг. в ГУ «Республиканский научно-практический центр «Мать и дитя». В основную группу вошли 742 пациентки с индуцированными родами. Группу сравнения составили 108 пациенток с самостоятельно развившейся регулярной родовой деятельностью.Результаты. Проведена оценка влияния срока беременности при индуцированных родах на акушерские и перинатальные исходы. При индукции родов в сроке 41/0 неделя и более выше риски развития следующих акушерских и перинатальных осложнений по сравнению с индукцией родов в 39/0–39/6 недель беременности: первичная слабость родовой деятельности – OR 3,2 (95% ДИ 1,3–7,9), дистресс плода в родах – OR 2,7 (95% ДИ 1,3–5,8), экстренное родоразрешение путем операции кесарева сечения – OR 2,8 (95% ДИ 1,4–5,4), крупновесный новорожденный – OR 2,6 (95% ДИ 1,1–5,9), асфиксия при рождении – OR 15,0 (95% ДИ 1,5–147,5). Заключение. Следовательно, развитие акушерских и перинатальных осложнений зависит от срока беременности при индукции родов.
The purpose of the study: to assess the likelihood of developing obstetric and perinatal outcome of induction of labor, depending on the duration of pregnancy.Material and methods. A retrospective analysis of obstetric and perinatal outcomes was carried out according to 850 birth histories (form No. 096/y) for 2015-2019 in the Republican Scientific and Practical Center "Mother and Child". The main group included 742 patients with induction of labor. The comparison group consisted of 108 patients with independently developed regular labor.Results. The effect of gestational age on induced births on obstetric and perinatal outcomes is assessed. With the induction of labor at 41/0 weeks or more, the risks of developing the followingobstetric and perinatal complications are higher than with the induction of labor at 39/0-39/6 weeks of pregnancy: primary weakness of labor – OR 3.2 (95% CI 1,3–7.9), fetal distress at birth – OR 2.7 (95% CI 1.3–5.8), emergency delivery by cesarean section – OR 2.8 (95% CI 1.4–5,4), a large-weightednewborn – OR 2.6 (95% CI 1.1–5.9), asphyxia at birth – OR 15.0 (95% CI 1.5–147.5).Conclusion. Therefore, the development of obstetric and perinatal complications depends on the gestational age during the induction of labor.
The Value of the DNA Fragmentation Index in the Diagnosis of Male Infertility
Authors: Батуревич Л.В. , Шилейко И.Д. , Алехнович Л.И. , Коломиец А.О. , Кузьменко А.Т. 
Published: March 2022

Введение. Фрагментация ДНК, отражая нарушение целостности генома сперматозоида, может служить важным диагностическим и прогностическим критерием оценки фертильности мужчин.Цель. Установить клинико-лабораторную значимость определения ДНК-фрагментации сперматозоидов в качестве теста оценки фертильности эякулята мужчин, страдающих бесплодием.Материалы и методы. Методами световой микроскопии у 105 мужчин с бесплодием осуществлено исследование спермограммы и степени выраженности ДНК-фрагментации сперматозоидов с использованием набора реагентов Halosperm G2. Результаты. Установлена связь индекса фрагментации ДНК с подвижностью и жизнеспособностью сперматозоидов у инфертильных мужчин с олиго- и нормозооспермией.Выводы. Полученные данные позволяют сделать вывод о целесообразности оценки фрагментации ДНК сперматозоидов у мужчин с олигозооспермией. Определение дисперсии хроматина может быть рекомендовано в качестве скринингового теста для оценки фертильности мужчины.
Introduction. DNA fragmentation, reflecting the violation of the integrity of the sperm genome, can serve as an important diagnostic and prognostic criterion for assessing male fertility.Purpose. To establish the clinical and laboratory significance of determining the DNA fragmentation of spermatozoa as a test for assessing the fertility of the ejaculate of men suffering from infertility.Materials and methods. Using light microscopy methods, 105 men with infertility studied the semen analysis and the severity of DNA fragmentation of spermatozoa using the Halosperm G2 reagent kit.Results. The relationship between the DNA fragmentation index and the mobility and viability of spermatozoa in infertile men with oligo- and normozoosprmia has been established.Conclusions. The data obtained allow us to conclude that it is expedient to assess the DNA fragmentation of spermatozoa in men with oligozoospermia. The chromatin dispersion (SCD) method can be recommended as a screening test to assess male fertility.
Obtaining an aseptic culture of grape rootstocks
Authors: Павлова И.А. , Косюк М.И. 
Published: March 2022

В связи с возрастающей потребностью в получении материала высоких категорий качества для закладки маточников подвойных лоз винограда проводятся исследования по оптимизации всех этапов технологии клонального размножения подвоев in vitro . Цель настоящего исследования состояла в изучении особенностей морфогенеза подвоев винограда в системе in vitro на этапе получения асептической культуры. В результате исследований выявлена сортовая специфичность морфогенеза у подвоев Гравесак 11, Гравесак 12 и Феркаль как на этапе побегообразования, так и укоренения. Подвои отличались по регенерирующей способности почки, укоренению побегов, размерам морфологических структур. Установлено, что питательная среда MS, содержащая БАП в концентрации 0,4 мг/л применима для индукции побегообразования на этапе введения в культуру in vitro подвоев, а среда PG, содержащая НУК в концентрации 0,05 мг/л - для укоренения образовавшихся побегов. Предстоит, учитывая особенности морфогенеза, выработать стратегию эффективного размножения, для каждого отдельного сорта.
In connection with the growing need to obtain the material of high quality categories for establishment of rootstock vine nurseries, the research on optimization of all stages of rootstock clonal propagation technology in vitro is carried out. The purpose of this research was to study features of grape rootstock morphogenesis in the system in vitro at the stage of obtaining an aseptic culture. As a result of the research, the varietal specificity of morphogenesis was revealed in rootstocks ‘Gravesac 11’, ‘Gravesac 12’ and ‘Ferkal’ at both stages of shoot formation and rooting. The rootstocks differed in bud regenerative ability, shoot rooting, and the size of morphological structures. It was established that the MS nutrient medium, containing BAP at a concentration of 0.4 mg/l, is applicable for induction of shoot formation at the stage of introducing rootstocks into in vitro culture, and the PG medium, containing NAA at a concentration of 0.05 mg/l - for rooting the newly formed shoots. It is necessary, taking into account the peculiarities of morphogenesis, to develop a strategy of effective reproduction for each individual variety.
Recent Trends in Regulatory Design - Stakeholder Engagement in Regulatory Impact Assessment
Authors: Śliwa Renata 
Published: March 2022

Research objective: Justification of stakeholder engagement as a possible pillar of efficient regulatory governance
The research problem and methods: To visualize the significance of stakeholder engagement to regulation, the OECD data on stakeholder engagement are interpreted. Then, the case studies of the stakeholder engagement within regulatory impact assessment procedures in the European Union, Korea and the United Kingdom are highlighted. The methodology is based on the comparative analysis of the OECD secondary data and case study comparative analysis.
The process of argumentation: Starting from a view of regulatory policy as the realization of policy goals with regulation, law, and other instruments through which a higher standard of living of the population can be achieved. Concluding with the reasoning that stakeholder engagement is a crucial component of a check-and-balance mechanism in regulatory governance.
Research results: The stakeholder-engagement-driven three-layer division covers: Policy-driven layer (strategy) determined by the contemporary challenges stemmed from emancipation of association consciousness and movements and ICT revolution; Administration-driven layer (operationalization) determined by effectiveness and efficiency as well as public service imperatives; Governance-driven layer serving as the exponent of varieties of conflicting and complementing ideas and interest of social groups, check and balance in the process of monitoring, legitimization and accountability of regulators while wide-spreading the essential public services.
Conclusions, innovations, and recommendations: Stakeholder engagement as a crucial part of regulatory impact assessment has been the pivotal element of the systemic adjustments reaching out to the behavioral adaptations, and to the institutionalization of evidence-based policy making.
Vertical β-Ga2O3 Schottky barrier diodes with trench staircase field plate
Authors: Kumar Sandeep , Murakami Hisashi , Kumagai Yoshinao , Higashiwaki Masataka 
Published: March 2022

Abstract
This study presents vertical Ga2O3 Schottky barrier diodes (SBDs) with a staircase field plate on a deep trench filled with SiO2. It was clarified from device simulation that at high reverse voltage operation, the staircase field plate and the deep trench can effectively alleviate electric field concentration in the Ga2O3 drift layer and the SiO2 layer, respectively. The Ga2O3 SBDs successfully demonstrated superior device characteristics typified by an on-resistance of 7.6 mΩ cm2 and an off-state breakdown voltage of 1.66 kV. These results offer the availability of the trench staircase field plate as an edge termination structure for the development of Ga2O3 SBDs.
Aplikasi laser dalam bidang ortodontik (Laser application in orthodontic)
Authors: Yolwan Tri Mirda Ningsih , Erwansyah Eka 
Published: March 2022

Laser dalam kehidupan sehari-hari tidak lagi terdengar asing. Laser yang kita ketahui memiliki banyak kegunaan, terutama dalam dunia medis laser sudah sangat populer. Saat ini laser sudah semakin berkembang ke dalam dunia kedokteran gigi. Dengan aplikasi laser, sangatlah memungkinkan untuk melaksanakan penanganan pada banyak kondisi jaringan lunak yang seringkali menjadi tantangan dalam bidang ortodontik dan dapat mempengaruhi estetika hasil secara keseluruhan, serta memberikan penanganan dengan metode yang lebih mudah. Tujuan penulisan: Agar seluruh mahasiswa serta dokter gigi bisa lebih memahami tentang aplikasi laser dalam bidang ortodontik. Simpulan: Dalam bidang ortodontik, laser telah memiliki
banyak aplikasi, termasuk diantaranya mempercepat pergerakan gigi, remodeling tulang, dan etsa email
sebelum prosedur bonding, debonding bracket keramik dan penurunan rasa sakit setelah aplikasi tekanan
ortodontik dan pencegahan demineralisasi enamel. Aplikasi pada jaringan lunak seperti frenektomi,
contouring gingiva dan crown lengthening juga dapat dicapai dengan aplikasi laser dental ini.
Manifestasi klinis ulser rongga mulut pada penderita tuberkulosis
Authors: . Sumintarti , Sativa Oryza 
Published: March 2022

Tuberkulosis (TB) adalah penyakit infeksi menular yang menyerang berbagai organ tubuh terutama paru-paru yang disebabkan bakteri Mycobacterium tuberculosis. Penderita TB dapat menunjukkan gambaran klinis oral walaupun sangat jarang. Salah satunya yaitu ulser, yaitu lesi yang berupa hilangnya lapisan epitel hingga dibawah jaringan mukosa. Penelitian ini dilakukan untuk mengetahui gambaran klinis ulser rongga mulut pada penderita TB dan keberadaan infeksi bakteri Mycobacterium tuberculosis terhadap ulser. Penelitian observasional analitik dengan desain cross-sectional study ini dilakukan melalui pemeriksaan rongga mulut pada 30 penderita TB untuk melihat adanya ulser dan gambaran klinisnya. Untuk melihat keberadaan Mycobacterium tuberculosis dengan kultur pada medium Lowenstein-Jensen serta pewarnaan Ziehl-Neelsen.Penelitian ini menunjukkan bahwa kejadian ulser pada penderita TB ditemukan pada satu orang dengan gambaran klinis ulser berupa lesi tunggal, terletak di gingiva bukal rahang atas, ireguler, batasnya jelas, dan tidak nyeri. Hasil kultur laboratorium menunjukkan bahwa tidak ditemukan infeksi dari Mycobacterium tuberculosis. Dalam penelitian ini diketahui bahwa angka kejadian ulser pada penderita TB yaitu 3,3% dan ulser TB bersifat non spesifik pada gambaran klinisnya.
Kata kunci: tuberkulosis, ulser, Mycobacterium tuberculosis
ABSTRACT
The Correlation Between Children Who Use Bottle Feeding Ages 4 - 6 Years Against The Malocclusion
Authors: Imani Faziha Nurul , Habar Eddy Heriyanto 
Published: March 2022

ABSTRACT
Background: The prevalence of malocclusion in Indonesia is still very high at around 80% of the population and is one of the major dental and oral health problems, this is coupled with a low level of dental care awareness. The prevalence of malocclusion because of the habit of drinking milk with bottle feedings was 49.5% of 377 children. This is habit because, the habit of drinking milk with a bottle feeding causes the movement of the baby's tongue like a sucking motion. This abnormal tongue motor activity will result in aberrant swallowing habits which will eventually cause malocclusion. Purpose: To determine the correlation between children using bottle feeding aged 4 - 6 years to the occurrence of malocclusion. Methods: This study uses the Analytical Observational method with a cross sectional study design. The sample consisted of 30 children aged 4 - 6 years who met the criteria of the study determined by filling out questionnaires and intra-oral examination of samples Result: The result of Spearman's correlation statistical test, obtained the correlation coefficient value (r=0.435) which shows a moderate correlation. The results of the linear regression test to see if there are long-term effects of using a bottle feeding on the occurrence of malocclusion, obtained a value (p <0.05) which shows a significant effect. Conclusion: There is a moderate correlation between children who use bottle feedings aged 4-6 years to malocclusion. The longer children use bottle feeding, the more severe the malocclusion of children.
Keywords: Malocclusion, Bottle feeding