bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visual Acuity After Vitrectomy Combined Phaco Fragmentation in Patients Having Trauma Ocular Contusion in Vietnam
Authors: Nguyen Le Trung , Nguyen Kien Trung 
Published: June 2022

Abstract
Purpose
To evaluate visual acuity pre and post-vitrectomy combined phaco fragmentation and fixation scleral IOL in patients with contusion trauma to the eyeball.
Patients and Methods:
Prospective, interventional, non-control study, from July 2018 to October 2021 at the National Eye Hospital. One hundred three patients (69 men/34 women). We assessed visual acuity before and after surgery at each time point lasting up to one year after surgery. The related factors were evaluated by multivariable logistic regression.
Results
Comparing the visual acuity results between the time points before surgery, after surgery, 2 weeks and 1 month showed a statistically significant difference with p < 0.05. After 6 months of surgery, the rate of a visual outcome of 0.2 or more was 56%. At 12 months, the rate of visual acuity of 0.2 or more was 51.6%. Factors related to surgical results include: age under 40 years (OR = 1.8, p < 0.05), position of lens luxation (OR = 2.0, p < 0.05), corneal edema (OR = 4.8, p < 0.05), iridodialysis (OR = 3.0, p < 0.05), pupil dilation (OR = 3.4, p < 0.05) and vitreous hemorrhage (OR = 2.8, p < 0.05).
Conclusion
The results of vitrectomy combined with phaco fragmentation fixed IOL improved visual acuity after 12 months. Factors related to visual acuity outcomes include age, the position of lens deviation, corneal opacity, iris tear, pupil dilation, and vitreous hemorrhage.
Managing the Information and Analytical Data System on Interaction Between Corium and Structural Materials of a Power Reactor
Authors: Kudranova Adiya , Syssaletin Andrey , Baklanova Yulia , Vurim Alexander , Yermakov Vladimir , Islamov Ramil 
Published: June 2022

Abstract
This paper presents the results on designing of an information and analytical data system that characterizes the interaction between melt of the core of a nuclear reactor and structural materials of the corium retention devices (melt traps), which were resulted from physical modeling the processes of a severe accident at the stands of Institute of Atomic Energy Branch of the Republican State Enterprise “National Nuclear Center of the Republic of Kazakhstan”.
An investigation of the effects of B7-H4 gene rs10754339 and miR‐125a gene rs12976445 on cancer susceptibility
Authors: Jin Yuchen , Dong Lijuan , Yang Qinyue , Xiong Weining , Wang Weiyi , Feng Xianhong , Yu Wei , Huang Wei , Chen Bifeng 
Published: June 2022

Abstract
The B7-H4 gene rs10754339 and miR-125a gene rs12976445 have been repeatedly investigated for their contribution to cancer susceptibility. However, only a few types of cancer have been covered in previous studies, and their results were conflicting rather than conclusive. Thus, we here performed a case-control study and meta-analysis to further investigate the effects of rs10754339 and rs12976445 on cancer susceptibility. A total of 550 lung cancer patients, 460 gastric cancer patients, 480 liver cancer patients and 800 normal controls were recruited in present case-control study. The genotyping of rs10754339 and rs12976445 was performed with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The present case-control study showed that in Hubei Han Chinese population, rs10754339 was significantly associated with the risk of lung and gastric cancer but not liver cancer, and rs12976445 was significantly associated with the risk of lung cancer but not liver or gastric cancer. The following meta-analysis combining the data of previous related studies and present study indicated that rs10754339 and rs12976445 contributed to cancer susceptibility in Chinese population, and also revealed a significant association between rs10754339 and breast cancer risk, as well as between rs12976445 and lung cancer risk. Collectively, B7-H4 gene rs10754339 and miR‐125a gene rs12976445 may be the potential genetic markers for cancer susceptibility in Chinese population, which should be validated in future studies with larger samples in other ethnic populations.
Interaction between TGF-β1 and long non-coding RNA 4.9 in a model of latent infection with human cytomegalovirus
Authors: Yi Xiaolian , Liu Lifang , Tao Ran , Li Wei , Li Huamei , He lin , Liu Yujie , Shang Shiqiang 
Published: June 2022

Abstract
To investigate the interaction between long non-coding RNA4.9 (lncRNA4.9) and transforming growth factor-β1 (TGF-β1) in the model of HCMV DNA. The experiment was divided into 5 groups: NC group, PCDNA-lncRNA4.9 group, SH-lncRNA4.9 group, LV-TGF-β1) Group, and SH-lncRNA4.9 group. Compared with the NC group, overexpression of lncRNA4.9 could significantly increase (P <0.05) the expression of TGF-β1 and decrease with time. The relative expression of HCMV DNA was significantly decreased (P <0.05) with the overexpression of lncRNA4.9. Compared with the NC group, overexpression of TGF-β1 significantly increased the expression of lncRNA4.9 and decreased with time. The relative expression of HCMV DNA was significantly decreased (P <0.05) with the overexpression of TGF-β1. However, silencing TGF-β1 could not reduce the relative expression of lncRNA4.9, but increased the relative expression of lncRNA4.9 on day 5, and the difference was statistically significant (P <0.05). Silencing lncRNA4.9 could not reduce expression of TGF-β1, but increased expression of lncRNA4.9 on day 5 (P <0.05). Overexpression of TGF-β1 could increase the relative expression level of lncRNA4.9 and decrease with time, and reduce the relative expression level of HCMV DNA, thus promoting HCMV into the latent infection state.
Improvements of Polya Upper Bound for Cumulative Standard Normal Distribution and Related Functions
Authors: eidous omar mohammad 
Published: June 2022

Abstract
Although there is extensive literature on the upper bound for cumulative standard normal distribution Φ(χ), there are relatively not sharp for all values of the interested argument χ. The aim of this paper is to establish a sharp upper bound for Φ(χ), in the sense that its maximum absolute difference from Φ(χ) is less than 5.785 x10-5 for all values of χ ≥ 0. The established bound improves the well-known Polya upper bound and it can be used as an approximation for Φ(χ) itself with very satisfactory accuracy. Numerical comparisons between the proposed upper bound and some other existing upper bounds have been achieved, which shows that the proposed bound is tighter than alternative bounds found in the literature.
Electrochemical arc micro-drilling of Nickel-Titanium SMAs utilizing GRA-based AHP and RSM
Authors: KUMAR NITISH , Kumar Amaresh 
Published: June 2022

Abstract
Electrochemical arc machining (ECAM) is a hybrid technique which is discovered by the further development of ECDM. As Nickel-Titanium is a hard-to-cut shape memory alloy, therefore ECAM has been utilized. For any manufacturing industry, the machining characteristics are an essential component of the process for the production of NiTi-based things, therefore in this study, MRR, TWR, over cut, and delamination have been chosen as performance parameters whereas voltage, electrolyte concentration (ethanol with ethylene glycol and NaCl), and tool rotation has been selected as variable parameters. The molybdenum has a low tendency to react chemically, therefore it was chosen as a tool for drilling NiTi. The optimum drilling condition has been detected as 20 v/v% of electrolyte concentration, 0 rpm of tool rotation, and 80V of voltage with help of the GRA-based AHP technique, and further, the GRG was optimized by RSM. The optimum value of the performance parameter has been observed as 101.19 mg/min, 0.006 mg/min, 0.111, and 1.16 for MRR, TWR, OC, and delamination respectively. The SEM analysis revealed HAZ, a white layer, melted droplet, number of cavities, craters, and microvoids near the drilled hole. Furthermore, EDX analysis proved that the work surface can be free of Mo after machining Nitinol by electrochemical arc machining. Also, the XRD analysis revealed the development of carbides like TiC in the melting zone of a drilled hole, where that carbide can vanish the shape memory properties in HAZ. As the electrolyte used is a water-free electrolyte, therefore no formation of oxides was observed.
Analysis and Design of Wide Band 28/38 GHz Antenna Array Integrated with 3D printed Dielectric Lens For 5G Automotive Applications
Authors: khairy A. , Elboushi A. , Shaalan A. A. , Ahmed M. F. 
Published: June 2022

Abstract
This paper presents the design of a Chebyshev linear antenna array (CLA) integrated with the dielectric lens. In comparison to a uniform amplitude distribution (UAD), a Chebyshev amplitude distribution (CAD) is used to achieve a low side lobe level (SLL) characteristic and increase the directivity of the antenna array. The proposed CLA is optimized to operate at a high fifth generation (5G) frequency. The proposed CLA achieves a -10 dB broadband width from 25.8 GHz to 42.4 GHz. The dielectric lenses can be employed to modify the phase and amplitude of the antenna array, which increases the realized gain and leads to stable radiation over the operational bandwidth. The main purposes of the dielectric lens are to improve the realized gain, enhance efficiency, and result in stable radiation pattern properties. The CLA is integrated with an epoxy resin dielectric lens, which has a relative permittivity (εr) of 2.716. The proposed CLA integrated with a dielectric lens has a realized gain of 15.2 dB at 28 GHz and 11.94 dB at 38 GHz, respectively. The proposed design is simulated using CSTMWS2020 and HFSS. However, to verify the obtained results, the proposed design is fabricated using a photolithography process technique, and the dielectric lens is fabricated using a 3D printing technique.
Degradation kinetics of artesunate for the development of an ex-tempore intravenous injection
Authors: Gashe Fanta , Wynendaele Evelien , De Spiegeleer Bart , Suleman Sultan 
Published: June 2022

Abstract
BackgroundArtesunate is recommended by the world health organization (WHO) for parenteral treatment of severe Plasmodium falciparum malaria. However, artesunate is inherently unstable in an aqueous solution and hydrolyses rapidly after its preparation for injection. Therefore, the aim of the study was to evaluate the stabilizing effects of phosphate buffer and mannitol against short-term (ex-tempore) artesunate hydrolysis.MethodsA HPLC-UV isocratic method was developed using a reversed-phase fused core column (HALO RP-C18) and a mobile phase consisting of a mixture of 45% ammonium formate 10 mM in water (pH 4.5) and 55% methanol. Artesunate was formulated as aqueous solutions using a design of experiment (DOE) to investigate the artesunate stabilizing effects of pH (8-10), phosphate buffer strength ( 0.3 – 0.5 M), and mannitol (0 – 0.22 mmol/mL). The solutions were incubated at predefined temperatures (5, 25, and 40 °C) with subsequent analysis. Arrhenius equation was applied to model and evaluate the stability results.ResultsThe developed HPLC-based method using fused-core stationary phase allowed to selectively quantify artesunate in the presence of its main hydrolysis degradants; namely β-dihydroartemisinin (β-DHA) and α-dihydroartemisinin (α-DHA) within 10 minutes. By applying the Arrhenius equation, the rate of hydrolysis of the drug increased approximately by 3.44 as the temperature raised by 10 ℃. Buffer strength was found to be the main factor affecting the hydrolysis rate constants at 5 and 25 ℃ (p<0.05), the activation energy (p = 0.007), and the frequency factor (p = 0.046). However, the effect of the buffer was predominant on the activation energy and hydrolysis rate constants, revealing its stabilizing effect on the drug at lower buffer strength (0.3 M). Within the investigated range (pH = 8-10), pH was found to influence the activation energy, with a positive stabilizing effect in the pH range of 8-9. The addition of mannitol as stabilizing agent into artesunate aqueous formulation did not show an improved response. ConclusionPhosphate buffer was the main stability determining factor of artesunate in the aqueous intravenous (i.v.) formulation and was found to be more effective in stabilizing artesunate at a buffer strength of 0.3 M in pH 8 to 9, while mannitol lacked stabilizing effect.
Nonlinear Generation of Fluting Perturbations by Kink Mode in a Twisted Magnetic Tube
Authors: Ruderman Michael , Petrukhin Nikolai 
Published: June 2022

Abstract
We study the excitation of fluting perturbations in a magnetic tube by an initially imposed kink mode. We use the ideal magnetohydrodynamic (MHD) equations in the cold-plasma approximation. We also use the thin-tube approximation and scale the dependent and independent variables accordingly. Then we assume that the dimensionless amplitude of the kink mode is small and use it as an expansion parameter in the regular perturbation method. We obtain the expression for the tube boundary perturbation in the second-order approximation. This perturbation is a superposition of sausage and fluting perturbations. The amplitude of the fluting perturbation takes its maximum at the middle of the tube, and it monotonically decreases with the distance from the middle of the tube.
Sorting of viable unlabeled cells based on deep representations links morphology to multiomics.
Authors: Salek Mahyar , Li Nianzhen , Chou Hou-Pu , Sinai Kiran , Jovic Andreja , Jacobs Kevin , Johnsson Chassidy , Lee Esther , Chang Christina , Nguyen Phuc , Mei Jeanette , Pant Krishna , Wong-Thai Amy , Smith Quillan , Huang Stephanie , Chow Ryan , Cruz Janifer , Walker Jeff , Chan Bryan , Musci Thomas , Ashley Euan , Masaeli Maddison 
Published: June 2022

Abstract
Phenotyping of single cells has dramatically lagged advances in molecular characterization and remains a manual, subjective, and destructive process. We introduce Computational Sorting and Mapping of Single cells (COSMOS), a platform for phenotyping and enrichment of cells based on deep learning interpretation of high-content morphology data in realtime. By training models on an atlas of >1.5 billion images, we demonstrate enrichment of unlabeled cells up to 33,000-fold. By applying COSMOS to tissue samples we identify malignant cells with similar accuracy to molecular approaches while enriching cells for functional evaluation. We show high-dimensional embedding vectors of morphology without any need for complex sample pre-processing, gating, or bioinformatics capabilities, which enables discovery of cellular phenotypes and integration of morphology into single-cell multimodal analyses as a new “omic”. Sorting intact cells based on deep morphological representations could further provide a powerful tool for tying together data across different modalities.
The presence of P. malariae and P. knowlesi in near malaria elimination setting in western Indonesia
Authors: Lubis Inke Nadia Diniyanti , Nainggolan Irbah Rea Alvieda , Syafutri Rycha Dwi , Sinambela Monica Nadya , Devina Clara , Handayani Handayani , Hasibuan Beby Syofiani , Permatasari Ranti , Chuangchaiya Sriwipa , Divis Paul C S , Id Zulkarnain Md 
Published: June 2022

Abstract
Background
Indonesia is progressing towards malaria elimination. To achieve this goal, intervention measures must be addressed to cover all types of Plasmodium species. Comprehensive control measures and surveillance programs must be intensified. This study aims to determine the prevalence of microscopic and submicroscopic malaria in Langkat district, North Sumatera Province, Indonesia.
Methods
A cross-sectional survey was conducted in six villages in Langkat district, North Sumatera Province in June 2019. Data were recorded using a standardized questionnaire. Finger pricked blood samples were obtained for malaria examination using rapid diagnostic test, thick and thin blood smears, and polymerase chain reaction.
Result
A total of 342 individuals were included in the study. Of them, one (0.3%) had a microscopic Plasmodium malariae infection, no positive RDT examination, and three (0.9%) were positive for P. malariae (n = 1) and Plasmodium knowlesi (n = 2). Almost half of the participants had bed nets (40%), had a house within a radius 100–500 m from the forest (86.3%), and had the housing material of cement floor (56.1%), a tin roof (82.2%), wooden wall (35.7%), bamboo wall (28.1%), and brick wall (21.6%).
Conclusion
Malaria incidence has substantially decreased in Langkat, North Sumatera, Indonesia. However, submicroscopic infection remains in the population and may contribute to further transmission. Surveillance should include the detection of microscopic undetected parasites, to enable the achievement of malaria elimination.
'It is a hard decision': A qualitative study of women's experiences with perinatal intimate partner violence disclosure
Authors: Barez Malikeh Amel , Najmabadi Khadijeh Mirzaii , Roudsari Robab Latifnejad , Bazaz Mojtaba Mousavi , Babazadeh Raheleh 
Published: June 2022

Abstract
Background
Perinatal intimate partner violence is a hidden under reported and difficult to identify problem which has negative effects on mother and child. The present study aimed to explore women's experiences with perinatal intimate partner violence disclosure.
Methods
This qualitative study was carried out from October 2019 to January 2021 in Mashhad, Iran. Participants included 23 abused women (11 pregnant and 12 postpartum) which were selected via purposive sampling. Semi-structured in-depth interviews and focus group discussion were conducted until the data saturation was achieved. The data analysis was performed based on conventional content analysis adopted by Graneheim & Lundman.
Results
The main themes "barriers to disclosure" and "facilitators of disclosure" were emerged as the result of data analysis. Barriers to disclosure included negative disclosure consequences. Facilitators of disclosure included maternal self-efficacy, intensity of violence, and formal and informal supportive networks.
Conclusions
Most abused women did not disclose violence despite routine screening for perinatal intimate partner violence in antenatal care. Recognizing the barriers to and facilitators of violence disclosure play an important role in eliminating barriers, strengthen facilitators, providing effective supportive services for abused women, and reducing perinatal violence. Focus on the barriers to and facilitators of disclosure will be useful to policymakers, health program planners, and health care providers to identify and manage intimate partner violence, appropriately.
GPRIN1 promotes gallbladder cancer progression through the CDK1 pathway
Authors: Li Min , Shen Feng , Ni Xiaojian , Gong Zijun , Song Lujun , Suo Tao , Liu Han , Shen Sheng , Liu Houbao , Ni Xiaoling 
Published: June 2022

Abstract
Purpose Recent studies have shown that G protein-regulated inducer of neurite outgrowth 1 (GPRIN1) regulates cancer proliferation and migration. However, there is limited research regarding its role in gallbladder cancer (GBC). We aimed to investigate the mechanism by which GPRIN1 promotes GBC cell proliferation and migration. Methods Immunohistochemistry was performed to visualize in situ GPRIN1 expression in 65 human GBC tissues and 59 corresponding normal tissues. The Kaplan–Meier method was used to analyze the correlation between GPRIN1 and overall survival. Cell proliferation (Celigo and MTT), apoptosis (FACS), and cell migration and invasion assays and a subcutaneous xenograft tumor model were used to define the effects of GPRIN1 downregulation in GBC cells in vitro and in vivo. Coimmunoprecipitation assays, mass spectrometry and Western blotting were performed to identify GPRIN1-interacting proteins. Cell proliferation, MTT and Transwell assays were performed to verify the functional recovery effect of cyclin-dependent protein kinase 1 (CDK1) on GPRIN1. Proteomic analysis of differentially expressed proteins and/or phosphorylated peptides was performed. Results GPRIN1 is upregulated in GBC tumor tissues and high GPRIN1 expression is positively correlated with a poor prognosis in GBC patients. High GPRIN1 expression reinforced the proliferative and invasive capacities of GBC in vitro and in vivo. Coimmunoprecipitation assays, mass spectrometry and Western blotting validated the direct interaction between GPRIN1 and CDK1. Cell proliferation, MTT and Transwell assays suggested that CDK1 exerts a functional recovery effect on GPRIN1. Proteomic analysis revealed the involvement of CDK1 in many biological processes and cellular pathways. Conclusions GPRIN1 promotes the invasion and metastasis of GBC cells via CDK1 pathway activation.
Renal Cell Carcinoma: A Comprehensive in Silico Study in Searching for Therapeutic Targets
Authors: Naghdibadi Mohammadjavad , Moemeni Maryam , Yavari Parvin , gholaminejad Alieh , Roointan Amir 
Published: June 2022

Abstract
Background: Renal cell carcinoma (RCC) is recognized as one of the main causes of illness and death worldwide. Understanding the molecular mechanisms in RCC pathogenesis is of utmost importance for discovering novel therapeutic targets and developing efficient drugs. With the application of a comprehensive in silico analysis of the RCC-related array sets, the main objective of this study was to discover the top molecules and pathways in the pathogenesis of this cancer.Methods: RCC microarray datasets were downloaded from the Gene Expression Omnibus database and after quality checking, normalization, and analysis using the limma algorithm, differentially expressed genes (DEGs) were identified considering the adjusted p-value < 0.049. The intensity values of the identified DEGs were introduced to the WGCNA algorithm for the construction of co-expression modules. Functional enrichment analyses were performed using the DEGs in the disease correlated module and hub genes were identified among the top genes in a protein-protein interaction network and the disease most correlated module. The expression analysis of hub genes was done by utilizing GEPIA and GSCA server was used to make a comparison between the expression patterns of hub genes in ccRCC and other cancers. DGIdb database was utilized to identify the hub genes related drugs.Results: Three datasets including GSE11151, GSE12606, and GSE36897 were retrieved, merged, normalized, and analyzed. Using WGCNA the DEGs were clustered into eight different modules. Translocation of ZAP-70 to immunological synapse, endosomal/vacuolar pathway, cell-surface interactions at the vascular wall, and immune-related pathways were the topmost enriched terms for the ccRCC correlated DEGs. Twelve genes including PTPRC, ITGAM, TLR2, CD86, PLEK, TYROBP, ITGB2, RAC2, CSF1R, CCR5, CCL5, and LCP2 were introduced as hub genes. All the 12 hub genes were up-regulated in ccRCC samples and showed a positive correlation with the infiltration of different immune cells. According to the DGIdb database, 127 drugs including tyrosine kinase inhibitors, glucocorticoids, and chemotaxis targeting molecules were identified to interact with the hub genes.Conclusions: By utilizing an integrative bioinformatics approach, this experiment shed a light on the underlying signaling pathways in the pathogenesis of ccRCC and introduced several potential therapeutic targets for repurposing or developing novel drugs for an efficient treatment of this cancer.