bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gambling and Financial Stress
Authors: Koomson Isaac , Churchill Sefa Awaworyi , Munyanyi Musharavati Ephraim 
Published: March 2022

AbstractIn recent years, gambling harm has been considered a significant public health concern due to its increasing socioeconomic costs. Although the adverse effects of gambling have attracted research interest, evidence of its effect on financial stress remains largely anecdotal. This study empirically examines the link between individual problem gambling severity and financial stress using panel data from the household, income and labour dynamics in Australia survey. After addressing endogeneity, we find that problem gambling severity is positively associated with self-reported financial stress. Thus, problem gambling severity tends to increase financial stress. This finding is robust to alternative measures of financial stress and gambling behaviour—whether gambling is measured using the problem gambling severity index, gambling risk statuses, number of gambling activities, or gambling expenditure. The positive effect of gambling on financial stress is largely driven by gambling activities involving scratch cards and poker machines. Although males exhibit higher levels of problem gambling severity, females are more financially stressed than males. Our findings also suggest that gambling widens the gender gap in financial stress. Further analysis reveals that financial resilience mediates the gambling-financial stress relationship. This implies that promoting policies that enhance financial resilience can help to insulate individuals against the effects of gambling on financial stress.
Energy Spectra vs. Element Abundances in Solar Energetic Particles and the Roles of Magnetic Reconnection and Shock Acceleration
Authors: Reames Donald V. 
Published: March 2022

AbstractWe reexamine the relationship between energy spectral indices and element abundance enhancements in solar energetic particle (SEP) events at energies of a few MeV amu−1. We find a correlated behavior only in the largest gradual SEP4 events when all ions are accelerated from the ambient coronal plasma by shock waves driven by fast, wide coronal mass ejections (CMEs). This correlated abundance behavior can track complex time variations in the spectral indices during an event. In other (SEP3) events, CME-driven shock waves, days apart, sample seed particles from a single pool of suprathermal impulsive ions contributed earlier. Of the smaller, Fe-rich, impulsive SEP events, previously related to magnetic reconnection in solar jets, over half are subsequently reaccelerated by CME-driven shock waves (SEP2), causing typical ion intensities to have a 64% correlation with shock speeds. In these SEP2 events, the onset of shock acceleration is signaled by a new component in the abundances, large proton excesses. The remaining SEP1 events lack evidence of shock acceleration. However, for all these events (SEP1–SEP3) with abundances determined by magnetic reconnection, energy spectra and abundances are decoupled.
Riv-Bonding of Aluminum Alloys with High-Strength Steels against the Favorable Joining Direction
Authors: Domitner Josef , Auer Peter , Stippich Jennifer , Silvayeh Zahra , Jessernig Sabrina , Peiser Lukas , Hönsch Florian , Sommitsch Christof 
Published: March 2022

AbstractIn order to exploit the advantages offered by multi-material design, this work studies the feasibility of joining aluminum alloys with high-strength steels (HSS) against the favorable joining direction by using self-piercing riveting (SPR) combined with adhesive bonding, so-called riv-bonding. Therefore, riv-bonding of four joint configurations including different aluminum alloy sheets (AW-6014-PX, AW-6451-T4), HSS sheets (HC420LA, HC450X) and rivet types (C5.3×8.0-H4, U5.5×5.0-H6) was experimentally investigated. Moreover, riv-bonding of two joint configurations was exemplarily modeled using the Simufact Forming finite element (FE) software. The viscoelastic properties of the liquid adhesive layer between the sheets were substituted with “equivalent” elastoplastic properties to model the adhesive as solid with strain rate-dependent flow behavior. Good agreement of joint cross sections and force-displacement curves between experiments and simulations confirms that the presented numerical model of riv-bonding is suitable for predicting both the joinability of aluminum alloys with HSS and the final quality of hybrid joints.
A “Sequential Design of Simulations” approach for exploiting and calibrating discrete element simulations of cohesive powders
Authors: Chen Xizhong , Pei Chunlei , Elliott James A. 
Published: March 2022

AbstractThe flow behaviours of cohesive particles in the ring shear test were simulated and examined using discrete element method guided by a design of experiments methodology. A full factorial design was used as a screening design to reveal the effects of material properties of partcles. An augmented design extending the screening design to a response surface design was constructed to establish the relations between macroscopic shear stresses and particle properties. It is found that the powder flow in the shear cell can be classified into four regimes. Shear stress is found to be sensitive to particle friction coefficient, surface energy and Young’s modulus. A considerable fluctuation of shear stress is observed in high friction and low cohesion regime. In high cohesion regime, Young’s modulus appears to have a more significant effect on the shear stress at the point of incipient flow than the shear stress during the pre-shear process. The predictions from response surface designs were validated and compared with shear stresses measured from the Schulze ring shear test. It is found that simulations and experiments showed excellent agreement under a variety of consolidation conditions, which verifies the advantages and feasibility of using the proposed “Sequential Design of Simulations” approach.
How do plants defend themselves against pathogens-Biochemical mechanisms and genetic interventions
Authors: Kaur Simardeep , Samota Mahesh Kumar , Choudhary Manoj , Choudhary Mukesh , Pandey Abhay K. , Sharma Anshu , Thakur Julie 
Published: March 2022

AbstractIn agro-ecosystem, plant pathogens hamper food quality, crop yield, and global food security. Manipulation of naturally occurring defense mechanisms in host plants is an effective and sustainable approach for plant disease management. Various natural compounds, ranging from cell wall components to metabolic enzymes have been reported to protect plants from infection by pathogens and hence provide specific resistance to hosts against pathogens, termed as induced resistance. It involves various biochemical components, that play an important role in molecular and cellular signaling events occurring either before (elicitation) or after pathogen infection. The induction of reactive oxygen species, activation of defensive machinery of plants comprising of enzymatic and non-enzymatic antioxidative components, secondary metabolites, pathogenesis-related protein expression (e.g. chitinases and glucanases), phytoalexin production, modification in cell wall composition, melatonin production, carotenoids accumulation, and altered activity of polyamines are major induced changes in host plants during pathogen infection. Hence, the altered concentration of biochemical components in host plants restricts disease development. Such biochemical or metabolic markers can be harnessed for the development of “pathogen-proof” plants. Effective utilization of the key metabolites-based metabolic markers can pave the path for candidate gene identification. This present review discusses the valuable information for understanding the biochemical response mechanism of plants to cope with pathogens and genomics-metabolomics-based sustainable development of pathogen proof cultivars along with knowledge gaps and future perspectives to enhance sustainable agricultural production.
Model architectures for bacterial membranes
Authors: Carey Ashley B. , Ashenden Alex , Köper Ingo 
Published: March 2022

AbstractThe complex composition of bacterial membranes has a significant impact on the understanding of pathogen function and their development towards antibiotic resistance. In addition to the inherent complexity and biosafety risks of studying biological pathogen membranes, the continual rise of antibiotic resistance and its significant economical and clinical consequences has motivated the development of numerous in vitro model membrane systems with tuneable compositions, geometries, and sizes. Approaches discussed in this review include liposomes, solid-supported bilayers, and computational simulations which have been used to explore various processes including drug-membrane interactions, lipid-protein interactions, host–pathogen interactions, and structure-induced bacterial pathogenesis. The advantages, limitations, and applicable analytical tools of all architectures are summarised with a perspective for future research efforts in architectural improvement and elucidation of resistance development strategies and membrane-targeting antibiotic mechanisms.
Intelligent Assistants
Authors: Dhiman Hitesh , Wächter Christoph , Fellmann Michael , Röcker Carsten 
Published: March 2022

AbstractIntelligent assistants are an increasingly commonplace class of information systems spanning a broad range of form and complexity. But what characterizes an intelligent assistant, and how do we design better assistants? In the paper, the authors contribute to scientific research in the domain of intelligent assistants in three steps, each building on the previous. First, they investigate the historical context of assistance as human work. By examining qualitative studies regarding the work of human assistants, the authors inductively derive concepts crucial to modeling the context of assistance. This analysis informs the second step, in which they develop a conceptual typology of intelligent assistants using 111 published articles. This typology explicates the characteristics (what or how) of intelligent assistants and their use context (who or which). In the third and final step, the authors utilize this typology to shed light on historical trends and patterns in design and evaluation of intelligent assistants, reflect on missed opportunities, and discuss avenues for further exploration.
The Effects of Mixing Pulp and Paper Mill Sludge Into Wood Bark on Storage-Related Environmental Impacts and Heating Value
Authors: Oksanen Juha , Keskinen Riikka , Heikkinen Jaakko , Kaseva Janne , Rasa Kimmo 
Published: March 2022

Abstract
The pulping industry generates vast amounts of bark and wastewater treatment sludges, which are combined and stored in stacks, often in the open air, prior to combustion for energy. The effects of incorporating sludge into bark on heating value and storage-related environmental impacts were investigated in laboratory and outdoors. Biological degradation was found to be higher in treatments containing 25% sludge (B75S25) and 50% sludge (B50S50) in comparison with pure bark (B100). Mean monthly dry mass loss was 2.1% (B100), 3.3% (B75S25), and 3.7% (B50S50) in the laboratory and 2.7, 4.2, and 4.8%, respectively, outdoors. Addition of sludge maintained degradation activity at low temperatures (+ 3 °C). Co-storage of sludge and bark led to loss of energy, mainly due to increased loss of biomass and increased moisture, which governed the heating value. Cumulative methane emissions were higher from the sludge-containing treatments than from pure bark, but emissions of nitrogen-containing gases (N2O and NH3) were negligible throughout. Sludge addition roughly halved the cumulative chemical oxygen demand (COD) of leachate and minimized its concentration of phosphate-P. However, larger amounts of inorganic elements were released from the sludge-containing treatments. Overall, these results indicate that finding alternative uses for the sludge fraction would be beneficial.

Graphical Abstract
Interpretation of Students’ Errors as Part of the Diagnostic Competence of Pre-Service Primary School Teachers
Authors: Larrain Macarena , Kaiser Gabriele 
Published: March 2022

AbstractUnderstanding students’ thinking and learning processes is one of the greatest challenges teachers face in the classroom. Misconceptions and errors have the potential to be a rich source of information for identifying students’ thinking and reasoning processes. However, empirical studies show that pre-service teachers (PSTs) and teachers find it challenging to focus their interpretations and pedagogical decisions on students’ thinking processes when they identify students’ mathematical errors.Based on the theoretical approach of noticing, the study described in this paper examines primary PSTs’ diagnostic competence in error situations before and after they participated in a seminar sequence implemented at several Chilean universities. Our analyses focus on PSTs’ competence with regard to formulating hypotheses about the causes of students’ errors. The proposed hypotheses were categorized into those that attributed errors to students’ lack of conceptual understanding, those that explained errors in terms of lack of procedural understanding, and those that assumed a failure of instructional strategies. In addition, the relationships between PSTs’ diagnostic competence, their beliefs and university learning opportunities were examined. The results indicate that PSTs’ diagnostic competence in error situations and the changes of this competence were related to PSTs’ beliefs, practical experiences, and learning opportunities. Overall, the findings suggest that it is possible to promote changes on PSTs’ diagnostic competence during initial teacher education. The paper concludes with implications for teacher education and future research.
PKC-β modulates Ca2+ mobilization through Stim1 phosphorylation
Authors: Song Hye-Jin , Jeon In-Sook , Kim Seung Ryul , Park Kwan Sik , Soh Jae-Won , Lee Kwang Youl , Shin Jae-Cheon , Lee Hak-Kyo , Choi Joong-Kook 
Published: March 2022

Abstract
Background
Calcium ions play a pivotal role in cell proliferation, differentiation, and migration. Under basal conditions, the calcium level is tightly regulated; however, cellular activation by growth factors increase the ion level through calcium pumps in the plasma membrane and endoplasmic reticulum for calcium signaling. Orai1 is a major calcium channel in the cell membrane of non-excitable cells, and its activity depends on the stromal interaction molecule 1 (Stim1). Several groups reported that the store-operated calcium entry (SOCE) can be modulated through phosphorylation of Stim1 by protein kinases such as extracellular signal-regulated kinase (ERK), protein kinase A (PKA), and p21-activated kinase (PAK). PKC is a protein kinase that is activated by calcium and diacylglycerol (DAG), but it remains unclear what role activated PKC plays in controlling the intracellular calcium pool.

Objectives
Here, we investigated whether PKC-β controls intracellular calcium dynamics through Stim1.

Methods
Several biochemical methods such as immune-precipitation, site directed mutagenesis, in vitro kinase assay were employed to investigate PKC interaction with and phosphorylation of Stim1. Intracellular calcium mobilization, via Stim1 mediated SOCE channel, were studied using in the presence of PKC activator or inhibitor under a confocal microscope.

Results
Our data demonstrate that PKC interacts with and phosphorylates Stim1 in vitro. phosphorylation of Stim1 at its C-terminal end appears to be important in the regulation of SOCE activity in HEK293 and HeLa cells. Additionally, transient intracellular calcium mobilization assays demonstrate that the SOCE activity was inhibited by PKC activators or activated by PKC inhibitors.

Conclusion
In sum, our data suggest a repressive role of PKC in regulating calcium entry through SOCE.
United Kingdom Copyright Decisions 2021
Authors: Lee Yin Harn 
Published: March 2022

AbstractThis report highlights the main UK copyright decisions in 2021. Most of these decisions deal with the right to communicate the work to the public in the context of website blocking injunctions, and provide insight into the British courts’ likely approach to EU-derived copyright principles following the end of the Brexit transition period. The report also discusses the high-profile case brought by the Duchess of Sussex against the operators of The Mail on Sunday and MailOnline for copyright infringement of a letter written by her to her father, which raised issues relating to originality and copyright exceptions.
Neurofilament-Leichtketten (NFL) als prognostischer Biomarker in der Diagnostik der multiplen Sklerose
Authors: Oremek G. M. , Passek K. , Braun M. , Droege J. , Ohlendorf D. 
Published: March 2022

ZusammenfassungDie vorliegende Übersicht zum Biomarker Neurofilament-Leichtketten (NFL) wird im Rahmen der Serie „Biomarker“ des Zentralblatts für Arbeitsmedizin, Arbeitsschutz und Ergonomie publiziert. Das NFL ist ein Serummarker in der Diagnostik der multiplen Sklerose. NFL eignet sich als Marker zur Therapie‑, Verlaufs- und Rezidivkontrolle von multipler Sklerose. Hier zeigt dieser eine hohe Sensitivität und Spezifität.
Quo vadis artificial intelligence?
Authors: Jiang Yuchen , Li Xiang , Luo Hao , Yin Shen , Kaynak Okyay 
Published: March 2022

AbstractThe study of artificial intelligence (AI) has been a continuous endeavor of scientists and engineers for over 65 years. The simple contention is that human-created machines can do more than just labor-intensive work; they can develop human-like intelligence. Being aware or not, AI has penetrated into our daily lives, playing novel roles in industry, healthcare, transportation, education, and many more areas that are close to the general public. AI is believed to be one of the major drives to change socio-economical lives. In another aspect, AI contributes to the advancement of state-of-the-art technologies in many fields of study, as helpful tools for groundbreaking research. However, the prosperity of AI as we witness today was not established smoothly. During the past decades, AI has struggled through historical stages with several winters. Therefore, at this juncture, to enlighten future development, it is time to discuss the past, present, and have an outlook on AI. In this article, we will discuss from a historical perspective how challenges were faced on the path of revolution of both the AI tools and the AI systems. Especially, in addition to the technical development of AI in the short to mid-term, thoughts and insights are also presented regarding the symbiotic relationship of AI and humans in the long run.
Addressing climate change through climate action
Authors: Tosun Jale 
Published: March 2022

AbstractThis editorial introduces the journalClimate Actionto its audience and defines its aims and scope. It first calls for the need to understand climate action as the choices and behavior of international organizations, governments, civil society, businesses, and individuals. Next, it discusses both the facilitators and impacts of climate action. The editorial concludes with a research agenda for climate action to be studied from a transdisciplinary perspective with practitioners for triggering widespread societal transformation.
Minority Stress and Sexual Functioning Among African American Women with At-Risk Partners in South Los Angeles
Authors: Schrode Katrina , Poareo Eliza , Li Michael , Harawa Nina T. 
Published: March 2022

ABSTRACTBackgroundPreliminary evidence indicates that acute and chronic psychological stress affect sexual arousal and satisfaction. African American women, in particular, are vulnerable to the impacts of gender- and race-related stress, given their socially constructed identities as African Americans and as women.AimWe examined associations between minority stress and sexual function using data from 248 African American women.MethodsSurveys were conducted with 248 African American women in South LA with male partners at risk for acquiring HIV. We analyzed self-reports on (i) stress indicators: chronic burden, perceived racism/sexism, and histories of trauma/sexual abuse; (ii) Female Sexual Function Index domains: desire, arousal, and satisfaction; and (iii) potential moderators: social support and spirituality. We used multiple regression, adjusting for potential confounding factors, to examine the relationships between stress indictors, potential moderators, and sexual function domains. Outcomes: The outcomes were the female sexual function index domains of desire, arousal, and satisfaction.ResultsThis largely low-income sample experienced significant chronic and acute stressors, was highly spiritual and reported strong social support. Moderate-high chronic burden and increasing sexism scores were independently associated with decreased arousal (B = -0.38, 95%CI = -0.75, -0.02) and satisfaction (B = -0.03, 95%CI = -0.06, 0.00) scores, respectively.Clinical ImplicationsProviders may want to explore chronic burden in patients who complain about low sexual arousal. Additionally, to develop effective HIV- and other STI-related interventions that impact behaviors that can confer sexual risk, prevention strategies are needed that either reduce contextual stressors or mitigate their impact.StrengthsStrengths of this research are that it focuses on sexual function among previously under-studied, low-income African American women and that it takes into account the unique set of stressors faced by these women.LimitationsA limitation is that the sample size may have been too small to capture the effects of potential moderators.ConclusionsLow-income African American women accumulate life stressors that may harm sexual function.
Comparison of the performance of a clinical classification tree versus clinical gestalt in predicting sepsis with extended-spectrum beta-lactamase–producing gram-negative rods
Authors: Smith Hayden L. , Elfeki Mohamed A. , Lowry Dana , Sabates Rebecca , Ropte Molly , Sittig Katherine R. , Finch Stephanie , Braun Kristina , Pruett William , Wasson Aaron , Fischman Kenna , Peterson Jennifer , Rosa Rossana 
Published: March 2022

Abstract
A clinical decision tree was developed using point-of-care characteristics to identify patients with culture-proven sepsis due to extended-spectrum β-lactamase–producing Enterobacterales (ESBL-PE). We compared its performance with the clinical gestalt of emergency department (ED) clinicians and hospital-based clinicians. The developed tree outperformed ED-based clinicians but was comparable to inpatient-based clinicians.