bluuebunny/crossref_metadata_2025_split huggingface dataset:
A missing link in affect regulation: the cerebellum
Authors: Frazier Madeleine R , Hoffman Linda J , Popal Haroon , Sullivan-Toole Holly , Olino Thomas M , Olson Ingrid R 
Published: June 2022

Abstract
The cerebellum is one-third the size of the cerebrum yet holds twice the number of neurons. Historically, its sole function was thought to be in the calibration of smooth movements through the creation and ongoing modification of motor programs. This traditional viewpoint has been challenged by findings showing that cerebellar damage can lead to striking changes in non-motor behavior, including emotional changes. In this manuscript, we review the literature on clinical and subclinical affective disturbances observed in individuals with lesions to the cerebellum. Disorders include pathological laughing and crying, bipolar disorder, depression and mixed mood changes. We propose a theoretical model based on cerebellar connectivity to explain how the cerebellum calibrates affect. We conclude with actionable steps for future researchers to test this model and improve upon the limitations of past literature.
Voice-Hearing Across The Continuum: A Phenomenology of Spiritual Voices
Authors: Moseley Peter , Powell Adam , Woods Angela , Fernyhough Charles , Alderson-Day Ben 
Published: June 2022

Abstract

Background and Hypothesis
Voice-hearing in clinical and nonclinical groups has previously been compared using standardized assessments of psychotic experiences. Findings from several studies suggest that nonclinical voice-hearing is distinguished by reduced distress and increased control. However, symptom-rating scales developed for clinical populations may be limited in their ability to elucidate subtle aspects of nonclinical voices. Moreover, such experiences often occur within specific contexts and belief systems, such as spiritualism. We investigated similarities and differences in the phenomenology of clinical voice-hearing and nonclinical voice-hearer (NCVH).

Study Design
We conducted a comparative interdisciplinary study which administered a semi-structured interview to NCVH individuals (N = 26) and psychosis patients (N = 40). The nonclinical group was recruited from spiritualist communities. We used content analysis and inductive thematic analysis to create a coding frame which was used across both spiritual and patient groups to compare phenomenological features of voice-hearing.

Study Results
The findings were consistent with previous results regarding distress and control. Additionally, in the NCVH group, multiple modalities were often integrated into 1 entity, and there were high levels of associated visual imagery, and subtle differences in the location of voices relating to perceptual boundaries. Most NCVHs reported voices before encountering spiritualism, suggesting that their onset was not solely due to deliberate practice.

Conclusions
Nonclinical spiritual voice-hearing has important similarities and differences to voices in psychosis. Future research should aim to understand how spiritual voice-hearers cultivate and control voice-hearing after its onset, which may inform interventions for people with psychosis with distressing voices.
Surveillance, Social Control, and Managing Semi-Legality in U.S. Commercial Cannabis
Authors: Kinney Alexander B 
Published: June 2022

Abstract
This article presents a case study of commercial cannabis in the United States. Drawing on 56 interviews with cannabis stakeholders collected between 2018–2020, I examine how different governmentalities of surveillance became distorted by the contradiction between state and federal cannabis laws. As in other regulated markets, these governmentalities informed state-sponsored surveillance initiatives to stop, contain, or support certain forms of deviance by commercial cannabis businesses. Due to fragmented governance, the efficacy of these initiatives depended in part upon the actions of the regulated cannabis industry. Commercial cannabis businesses looked to how surveillance was configured to develop strategies that could help them overcome challenges stemming from their semi-legality. These strategies included incorporating practices that were not required by law, partnering with the state in surveillance efforts, and engaging in activities to combat the black market. I argue that the embedded relationship between governmentalities, surveillance initiatives, and commercial cannabis activities transformed these strategies into mechanisms through which structure emerged in this nascent market. This paper introduces a set of surveillance categories, proposes new directions for research on social control and markets, and offers a novel study of commercial cannabis that can help to explain the trajectory of this market.
Structure of the Harmonin PDZ2 and coiled‐coil domains in a complex with CDHR2 tail and its implications
Authors: Yan Wenxia , Chen Guanhao , Li Jianchao 
Published: June 2022

AbstractHarmonin is a protein containing multiple PDZ domains and is required for the development and maintenance of hair cell stereocilia and brush border microvilli. Mutations in the USH1C gene can cause Usher syndrome type 1C, a severe inheritable disease characterized by the loss of hearing and vision. Here, by solving the high‐resolution crystal structure of Harmonin PDZ2 and coiled‐coil domains in a complex with the tail of cadherin‐related family member 2, we demonstrated that mutations located in the Harmonin PDZ2 domain and found in patients could affect its stability, and thus, the target binding capability. The structure also implies that the coiled‐coil domain could form antiparallel dimers under high concentrations, possibly when Harmonin underwent liquid–liquid phase separation in the upper tip‐link density in hair cell stereocilia or microvilli of enterocytes of the intestinal epithelium. The crystal structure, together with the biochemical analysis, provided mechanistic implications for Harmonin mutations causing Usher syndrome, non‐syndromic deafness, or enteropathy.
Promoting Safe Mobility
Authors: Olson Linda M. , Zonsius Mary C. , Rodriguez-Morales Grisel , Emery-Tiburcio Erin E. 
Published: June 2022

This article is the fifth in a series, Supporting Family Caregivers in the 4Ms of an Age-Friendly Health System, published in collaboration with the AARP Public Policy Institute as part of the ongoing Supporting Family Caregivers: No Longer Home Alone series. The 4Ms of an Age-Friendly Health System (What Matters, Medication, Mentation, and Mobility) is an evidence-based framework for assessing and acting on critical issues in the care of older adults across settings and transitions of care. Engaging the health care team, including older adults and their family caregivers, with the 4Ms framework can help to ensure that every older adult gets the best care possible, is not harmed by health care, and is satisfied with the care they receive.
The articles in this series present considerations for implementing the 4Ms framework in the inpatient hospital setting and incorporating family caregivers in doing so. Resources for both nurses and family caregivers, including a series of accompanying videos developed by AARP and the Rush Center for Excellence in Aging and funded by The John A. Hartford Foundation, are also provided. Nurses should read the articles first, so they understand how best to help family caregivers. Then they can refer caregivers to the informational tear sheet—Information for Family Caregivers—and instructional videos, encouraging them to ask questions. For additional information, see Resources for Nurses.
An Introduction to Yoga
Authors: Todd Betsy 
Published: June 2022

Editor's note: From its first issue in 1900 through to the present day, AJN has unparalleled archives detailing nurses' work and lives over more than a century. These articles not only chronicle nursing's growth as a profession within the context of the events of the day, but also reveal prevailing societal attitudes about women, health care, and human rights. Today's nursing school curricula rarely include nursing's history, but it's a history worth knowing. To this end, From the AJN Archives highlights articles selected to fit today's topics and times.
This article, from AJN's February 1976 issue, was written by Robin L. Wilson, a nurse and yoga instructor, who today is a member of the YogaNurse Academy. In this early AJN article on the subject, Wilson described the many benefits of the practice, and shared easy-to-follow instructions for a simple yoga routine. She noted, “These exercises can be adapted for patient care, taught to patients, or practiced by nurses to maintain their own health.”
In this issue, Angela Dossett and colleagues describe the results of a program of structured yoga sessions for patients hospitalized on a locked medical–psychiatric unit. The popular sessions, led by a nurse–yoga instructor, have expanded to all behavioral inpatient units at their facility.—Betsy Todd, MPH, RN
Destigmatizing alcohol use disorder among nurses
Authors: Rathburn Jill 
Published: June 2022

Abstract:
The use of alcohol to cope with work-related stress is an increasing problem among nurses. However, barriers to diagnosis and treatment keep nurses with alcohol use disorder (AUD) from getting the help they need. This article discusses the issues and treatment obstacles affecting AUD among nurses, and outlines compassionate, stigma-free paths forward.
Current Status and Challenges of Valvular Heart Disease Interventional Therapy
Authors: Zhang Yi , Xiong Tianyuan , Feng Yuan 
Published: June 2022

Abstract
Valvular heart disease (VHD) is common in the global population, occupying an heavy disease burden among aging population. Currently, it is the booming era of transcatheter VHD treatment, even with superiority than traditional open heart surgery in some clinical outcomes. We collected data sources mainly derived from published articles and conference presentations, including randomized controlled trials, first-in-man studies, clinical registries, and other single- or multi-center and prospective or retrospective clinical studies. This review summarized the relevant devices and researches of transcatheter aortic valve replacement, transcatheter mitral valve repair and replacement, transcatheter tricuspid valve repair and replacement, and transcatheter pulmonary valve replacement. Moreover, possible challenges of interventional therapy for various VHD in the future were discussed as well.
Seasonal Rise in Plastic Surgery during Ramadan: A Cross-sectional Survey
Authors: Gelidan Adnan G. 
Published: June 2022

Background:
While demand for plastic surgery continues to rise worldwide, there are no known seasonal differences in plastic surgery volume. This study aimed to evaluate whether Ramadan was associated with a measurable rise in demand for plastic surgery.

Methods:
This was a cross-sectional nationwide survey of plastic surgeons. Surgeon demographics, practice setting, case load, surgical preference during the month of Ramadan, factors associated with surgical volume, and procedures that were in demand during Ramadan were collected from all registered plastic surgeons in the Saudi Commission Health Specialties.

Results:
A total of 120 (73%) of 165 plastic surgeon completed the survey. The male:female ratio was 8:1. A total of 34 (28%) surgeons operated in public- and private-sector practices, and 53% (n = 64) maintained private practice only. When they operate, 60 (50%), 34 (28%), and 10 (8%) operate in the morning, in morning and evening, and in evening only, respectively. Although surgeons reported lower case volumes due to reduced working hours, 57% (n = 68) reported an increase in the proportion of cosmetic surgery. There was more than 80% consensus between surgeons on school vacation and ensuing wedding season as reasons for increased demand for plastic surgery.

Conclusions:
Seasonal demand for cosmetic plastic surgery was virtually unheard of. Although reduced working hours in Ramadan meant lower plastic surgery case volumes, surgeons reported an increase in the demand for cosmetic surgical and nonsurgical procedures during the month of Ramadan. School vacation and post-Ramadan social events were attributed as reasons for this rise.
Ageing with Interstitial lung disease: preserving health and well being
Authors: Saketkoo Lesley Ann , Obi Ogugua Ndili , Patterson Karen C. , Russell Anne-Marie 
Published: June 2022

Purpose of review
Ageing, the accrual of molecular and cellular damage over a lifetime confers progressive physiologic dysfunction of bodily systems, leaving the body in a heightened state of vulnerability to biophysical and psychosocial stressors. The inflection point is frailty which easily leads to disability and death. Interstitial lung disease (ILD) creates biophysical and psychosocial stresses difficult for even optimally fit patients to cope with. With evolving ILD treatment pathways, people with ILD are living longer.

Recent findings
ILD and ageing are bi-directionally influential: ILD, its treatments, complications, and collateral systemic extra-pulmonary damage (hypoxic and oxidative stress) wear on the ageing person and ageing impacts a person's tolerance of ILD. ILD extent may proportionally accelerate age-related vulnerabilities. ILD related to inflammatory systemic diseases, e.g. connective tissue diseases or sarcoidosis, exert an even more complex biophysical impact on the body.

Summary
The present review stresses goals of preventing frailty in ILD and preserving general health and well being of people living with ILD of any age, from time of diagnosis and as they age. The development of a prediction score is proposed to classify those at risk of frailty and guide interventions that preserve successful ageing for all levels of ILD severity.

Video abstract

http://links.lww.com/COPM/A32
Integrated 18F-FDG PET/CT parameter defines metabolic oligometastatic non-small cell lung cancer
Authors: Ma Rong , Zhao Qian , Zhao Ren , Li Juan , Wang Yan-Yang 
Published: June 2022

Aims
The purpose of this study was to define metabolic oligometastatic non-small cell lung cancer (NSCLC) by using the number of metastatic lesions and 18F-FDG PET/CT parameters.

Methods
One hundred twenty-four newly diagnosed stage IV NSCLC patients who received pretreatment 18F-FDG PET/CT examination were retrospectively analyzed. The maximum standardized uptake value (SUVmax) of primary and metastatic lesions and the collected clinical parameters were fed into the univariate and multivariate Cox proportional hazard model. Survival analysis was performed using Kaplan–Meier and log-rank test.

Results
In univariate analysis, the results revealed that histology, metastatic organ numbers, adrenal gland metastasis, SUVmax of both primary and metastatic lesions, lactate dehydrogenase, systemic treatment, and local treatment were significantly correlated with overall survival of stage IV NSCLC patients. Multivariate analysis demonstrated that SUVmax of primary lesions and systemic treatment were independent risk factors of stage IV NSCLC patients. The addition of primary lung cancer SUVmax to traditional method (only count the numbers of metastasis lesions) enhanced the identification of oligometastatic NSCLC and the C-index increased from 0.601 to 0.693.

Conclusion
We developed a method for the definition of metabolic oligometastatic NSCLC, which combined the number of organs involved, the number of metastatic lesions, and the SUVmax of primary lung cancer.
Comparison of plantar pressure distribution in underweight, normal, overweight, and obese adolescents: A cross-sectional study evaluation of plantar pressure in adolescents
Authors: Yıldırım Şahan Tezel , Türker Duygu , Söyler Osman 
Published: June 2022

Background:
Repeated overload by body weight in the adolescents affects the foot structure.

Objective:
This study aimed to evaluate plantar pressure distribution in adolescents with different body mass indices during gait and standing.

Study design:
This is a randomized, cross-sectional study.

Methods:
One hundred eighty-six adolescents between the ages of 8 and 15 years were included. The individuals were divided into groups according to body mass index (BMI). Plantar pressure distributions were examined during gait and standing. Surface areas, plantar pressures, forefoot-hindfoot load, surface amounts, and foot angles of the individuals were determined during gait and standing.

Results:
Significant differences were detected in left-right surfaces, maximum load quantities, average pressures, forefoot-hindfoot surface areas between static and dynamic plantar pressure distributions of underweight, normal, overweight, and obese adolescents (P < 001). Maximum, average pressure, right forefoot foot load, and foot angles increased in the obese group during standing as BMI increased; total surface areas, and loads in forefoot, hindfoot surface areas in right and left feet also increased in maximum and average pressures during gait (P < .05). No differences were detected between groups in foot angles during standing and gait (P > .05).

Conclusions:
This study show that increased BMI causes increased plantar pressures during gait and standing, and weight gain would cause problems in adolescents.
Assessment of Fat Fractions in the Tongue, Soft Palate, Pharyngeal Wall, and Parapharyngeal Fat Pad by the GOOSE and DIXON Methods
Authors: Song Ruitian , Hwang Scott N. , Goode Chris , Storment Diana , Scoggins Matthew , Abramson Zachary , Hillenbrand Claudia M. , Mandrell Belinda , Krull Kevin , Reddick Wilburn E. 
Published: June 2022

Objective
The 2-point DIXON method is widely used to assess fat fractions (FFs) in magnetic resonance images (MRIs) of the tongue, pharyngeal wall, and surrounding tissues in patients with obstructive sleep apnea (OSA). However, the method is semiquantitative and is susceptible to B0 field inhomogeneities and R2* confounding factors. Using the method, although several studies have shown that patients with OSA have increased fat deposition around the pharyngeal cavity, conflicting findings was also reported in 1 study. This discrepancy necessitates that we examine the FF estimation method used in the earlier studies and seek a more accurate method to measure FFs.

Materials and Methods
We examined the advantages of using the GOOSE (globally optimal surface estimation) method to replace the 2-point DIXON method for quantifying fat in the tongue and surrounding tissues on MRIs. We first used phantoms with known FFs (true FFs) to validate the GOOSE method and examine the errors in the DIXON method. Then, we compared the 2 methods in the tongue, soft palate, pharyngeal wall, and parapharyngeal fat pad of 63 healthy participants to further assess the errors caused by the DIXON method. Six participants were excluded from the comparison of the tongue FFs because of technical failures. Paired Student t tests were performed on FFs to detect significant differences between the 2 methods. All measures were obtained using 3 T Siemens MRI scanners.

Results
In the phantoms, the FFs measured by GOOSE agreed with the true FF, with only a 1.2% mean absolute error. However, the same measure by DIXON had a 10.5% mean absolute error. The FFs obtained by DIXON were significantly lower than those obtained by GOOSE (P < 0.0001) in the human participants. We found strong correlations between GOOSE and DIXON in the tongue (R
2 = 0.90), soft palate (R
2 = 0.66), and parapharyngeal fat pad (R
2 = 0.88), but the correlation was weaker in the posterior pharyngeal walls (R
2 = 0.32) in participants.

Conclusions
The widely used 2-point DIXON underestimated FFs, relative to GOOSE, in phantom measurements and tissues studied in vivo. Thus, an advanced method, such as GOOSE, that uses multiecho complex data is preferred for estimating FF.
Blastococcus tunisiensis sp. nov., isolated from limestone collected in Tunisia
Authors: Louati Moussa , Hezbri Karima , Montero-Calasanz Maria del Carmen , Rohde Manfred , Göker Markus , Ghodhbane-Gtari Faten , Klenk Hans-Peter , Nouioui Imen , Gtari Maher 
Published: June 2022

A new actinobacterium strain, designated BMG 823T, was isolated from a limestone sample collected in Tunisia. Its taxonomic position was scrutinized using a polyphasic approach. Colonies of strain BMG 823T were pink orange-coloured, regular and had a moist surface. Cells are Gram-stain-positive, catalase-negative and oxidase-negative. The strain grew at pH 5.5–9, 10–40 °C and in presence of up to 4 % NaCl (w/v). Chemotaxonomically, strain BMG 823T was characterized by cell-wall type III containing meso-diaminopimelic acid as diamino acid, glucose, ribose and rhamnose as whole-cell sugars, MK-9(H4) as predominant menaquinone, and phosphatidylcholine, diphosphadidylglycerol, phosphatidethanolamine, phosphatidylcholine, phosphatidylinositol, unidentified glycolipid, unidentified aminophospholipids and unidentified glycophospholipid as major polar lipids. The fatty acid profile consisted of iso-C16 : 0 and iso-C17 : 1
ω9. Phylogenetic trees based on 16S rRNA gene and genome sequences placed strain BMG 823T within the genus

Blastococcus

and separated it from all type strains of validly published species. Comparison of 16S rRNA gene sequence similarity, digital DNA–DNA hybridization and average nucleotide identity indicated that strain BMG 823T was most closely related to

Blastococcus litoris

DSM 106127T and

Blastococcus colisei

BMG 822T with pairwise values well below the species differentiation thresholds. The distinct phenotypic and genotypic features of strain BMG 823T (=DSM 46838T=CECT 8881T) within the genus

Blastococcus

warrant its recognition as the type strain for the new species for which we propose the name Blastococcus tunisiensis sp. nov.
On the biological constraints that limit the productivity of rain-fed annual crops
Authors: Kan Iddo , Tsur Yacov , Moshelion Menachem 
Published: June 2022

AbstractEfforts to cope with hunger by breeding highly productive annual crops for rain-fed agriculture in stochastic-rainfall environments have had only minor success, which we attribute to biological constraints that limit the crops’ yields. We use optimization modelling to interpret experimentally measured transpiration trajectories of wild barley plants following a rain event: the plants first maximized biomass accumulation by employing their maximal transpiration rate, then switched to their minimal transpiration rate to ensure survival until maturity. Thus, breeding plants with lower minimal transpiration rates combined with higher water-use efficiency and maximal transpiration rates could increase expected yields. However, our experimental results indicate that biological constraints impose tradeoffs among maximal and minimal transpiration rates and water-use efficiency. A proposed breeding methodology identifies less biologically constrained cultivar candidates.