bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental Health Nurses’ Perceptions of Providing Pharmaceutical Care in Saudi Arabia
Authors: Alhamidi Sami , Alyousef Seham 
Published: November 2022

Abstract
Purpose
To investigate caring roles in nurse pharmaceutical care and to offer an initial report of psychiatric/mental health nurses’ experiences of psychiatric pharmaceutical care.
Methods
This study used a qualitative exploratory focus group discussion with nine experienced psychiatric nurses. Inductive data were gathered using open-ended probes and theoretical sampling and were analyzed to yield themes and subthemes.
Results
Principal themes and subthemes emerged from the data analyzed. These themes illuminated nurses’ experiences with respect to the use of pharmaceutical medication in the mental health setting, including ​(i) nurses’ responsibilities for psychiatric pharmaceutical medications, (ii) experiences in multi-disciplinary teams, (iii) nurses’ knowledge and education regarding medication, and (iv) barriers faced by psychiatric nurses during practice.
Conclusion
Nurses involved in pharmaceutical care need additional training, interprofessional collaboration, and clearly codified parameters to guide their professional practice in this aspect of care. Working with medication is an important role of mental health nurses. However, little attention has focused on these nurses’ perspectives on where the responsibility lies for preparing nurses for safe, competent medication management of their patients.
Ten-Years functional and oncological outcomes of a prospective randomised controlled trial comparing laparoscopic versus robot-assisted radical prostatectomy
Running title: RARP vs LRP after 10 years of follow-up
Authors: Checcucci Enrico , De Cillis Sabrina , Alladio Eugenio , Piramide Federico , Volpi Gabriele , Granato Stefano , Zamengo Davide , Amparore Daniele , Piana Alberto , Manfredi Matteo , Vallariello Edoardo , Stura Ilaria , Dio Michele Di , Autorino Riccardo , Fiori Cristian , Porpiglia Francesco 
Published: November 2022

Abstract
Background: The aim of this study was to present oncological, functional and quality of life data after 10 years of follow-up of a prospective RCT comparing RARP vs LRP.
Methods: This is a single center prospective parallel two arms randomized control trial for patients with localized PCa, who underwent LRP or RARP between January 2010 and January 2011. Functional (continence and potency) and oncological (PSA, biochemical recurrence [BCR] and BCR free survival [BCRFS] variables were evaluated. BCRFS curves were estimated by the Kaplan- Meier method and compared using the log-rank test. Furthermore, machine learning PLS-DA was tested as supervised multivariate data analysis to identify the variables that characterize more the patients who underwent RARP or LRP.
Results and Limitations: of the 120 patients enrolled, 75 patients remained on follow-up for 10 years; 40 (53%) underwent RARP and 35 (47%) LRP. Long term data did not find significant advantages in terms of continence and potency recovery, despite a Δ12% for continence and Δ8% for potency in favour of robotic approach (p=0.068 and p=0.56 respectively). PLS-DA revealed that LRP was characterized by worst functional related outcomes analyzing the entire follow-up period. 4 (10%) and 6 (17%) patients experienced BCR in RARP and LRP Group respectively (p= 0.36) with an overall 10-yr BCR free survival of 88% and 78% (p=0.16). No differences were found at EPIC 45 and EPIC 1 questions at the end of the follow-up period (p = 0.30 and p = 0.57) respectively.
Conclusions: Similar continence and potency rate were found between RARP and LRP at 10 years of follow-up. However, better quality of micturition and sexual outcomes at the end of long term follow-up was reached with a higher rate of totally dry patients and better erections in terms of IIEF-5 score in RARP cohort. Similar oncological outcomes reported.
Difficult Aspects of Treatments Patients With Acute Lung Abscesses Who Survived COVID -19
Authors: S.S. Atakov , A.O. Okhunov , Sh.A. Bobokulova , U.K. Kasimov , A.R. Bobabekov 
Published: November 2022

Abstract
Suppurative diseases of the lungs are topical issues of pulmonology that require detailed study due to the difficulties of diagnosis and high mortality of patients. This is due to several objective and subjective reasons such as the widespread use of antibioticresistant microflora, which is especially important when antibiotics are prescribed unreasonably, even with a mild form of COVID − 19. This, of course, affects COVID patients, who already have reduced immunity. The question of the exact mechanism of development of purulent complications of the lungs after or during infection with COVID − 19 remains open. Clinical and radiological signs of a lung abscess often resemble the symptoms of pneumonia; however, antibacterial, and symptomatic therapy have differences. With gangrene of the lung, the increase in intoxication syndrome can be gradual, which reduces the doctor's alertness regarding the most severe disease and causes inadequate therapy. Comprehensive diagnostic measures, knowledge of the main clinical, instrumental and laboratory parameters are necessary for all physicians.
Secondary perianal Paget’s disease from adenocarcinoma of the anorectal juncture:a case report
Authors: He Jun , Shen Zhong , Peng Jian-Zhong , Wang Tao , Si-Jia Lu , Wang Hou-Dong , Zhang Xiu-Feng 
Published: November 2022

Abstract
Background：Secondary extramammary Paget’s disease (EMPD) is a rare EMPD-like lesion deriving from the cutaneous extension of malignant cells and easy to be misdiagnosed. In this report, we present a more rare case suffered from secondary perianal Paget’s disease(PPD )which is associated with adenocarcinoma of the anorectal juncture.
Case presentation：We experienced a rare case of secondary perianal Paget’s disease (PPD) which associated with adenocarcinoma of the anorectal juncture. Preoperative mapping biopsy was applied to the margin assessment. The patient recovered well with a comprehensive treatment.
Conclusion：Perianal Paget disease secondary to adenocarcinoma of the anal canal is a rare disease. Early diagnosis and treatment for secondary PPD are critical for prognosis.Preoperative mapping biopsy could be considered as an alternative technique for margin assessment.
Neutralizing antibodies from prior exposure negatively correlate with dengue viremia and may influence serotype dominance
Authors: Anantharaj Anbalagan , Agrawal Tanvi , Shashi Pooja , Tripathi Alok , Kumar Parveen , Khan Imran , Pareek Madhu , Singh Balwant , Kumar Saurabh , Pandey Rajesh , Chandele Anmol , Lodha Rakesh , Whitehead Steve , Medigeshi Guruprasad 
Published: November 2022

Abstract
India is hyperendemic to dengue virus and over 50% of the adults are seropositive but there is limited information on the association between prior dengue exposure with neutralizing antibody profiles and how this could influence virus evolution and vaccine development. In this work, we found that the dengue seropositivity increased with age and pre-existing antibody levels negatively correlated with viremia during acute phase of illness. Adults showed a higher levels of viremia which associated with lower levels of neutralizing antibodies as compared to children. The titers of neutralizing antibodies negatively influenced the dominance of circulating dengue serotypes with highest levels of the neutralizing antibodies against DENV-2 followed by DENV-1, DENV-3 and DENV-4. We observed minimal cross-reactivity of neutralizing antibodies with related flaviviruses such as Japanese encephalitis virus and West Nile virus and the antibodies elicited against Indian isolates show a reduced ability to neutralize international dengue isolates.
Fruit wine or grain liquor? Re-investigation for the residue of the bronze pot excavated from Beibai’e cemetery, Shanxi China
Authors: Li Yufang , Zhang Ganyu , Nan Puheng , Yang Jiyun , Cao Jun , Ma Zhikun , Ge Wei , Wen Rui 
Published: November 2022

Abstract
Beibai’e cemetery is a high-status noble tomb group of the early Spring-Autumn period (770 B.C − 476 B.C). A sealed bronze pot with mud and liquid residue was excavated from M1 tomb. The previous investigation showed that the residue was fruit fermented wine since the syringic acid was identified. However, it is in contradiction with the tradition of grain wine brewing in the central plains of China since the Neolithic period. The syringic acid was considered to be the unique biomarker of the fruit wine discussed in this paper. The multi-analytical techniques including FTIR, HPLC-MS, and plant microfossil analysis were applied in the study. The results indicated that the residue was considered to be grain liquor rather than fruit wine. The study showed that comprehensive analysis and multiple evidence were necessary for the wine residue research.
A versatile method to archive and delipidate brain tissues for ensuing multiplexed immunolabeling and organ-level imaging
Authors: Lin Ya-Hui , Wang Li-Wen , Chen Yen-Hui , Chan Yi-Chieh , Hu Shang-Hsiu , Wu Sheng-Yan , Chiang Chi-Shiun , Huang Guan-Jie , Yang Shang-Da , Chu Shi-Wei , Wang Kuo-Chuan , Lin Chin-Hsien , Huang Pei-Hsin , Cheng Hwai-Jong , Chen Bi-Chang , Chu Li-An 
Published: November 2022

Abstract
Current tissue clearing and labeling approaches require freshly prepared samples to avoid problems related to over-fixation, such as loss of antigenicity or difficulty of tissue clearing. Thus, the predicament of specimens with long-term preservation limits the application of state-of-art technology to archived human brain tissues. Here, we present the development and validation of multiplex labeling of centimeter-sized archived tissue (MOCAT)—a formalin-fixed paraffin-embedding (FFPE)–based sample preservation and delipidation technique for centimeter-level tissue clearing and immunolabeling. We demonstrate that MOCAT sufficiently delipidates whole mouse brain and human brain blocks and is superior to 10% formalin for long-term antigenicity preservation; moreover, the spatial information of biomarkers offered by MOCAT-processed intact mouse brains is identical to that offered by freshly prepared SDS-delipidated intact mouse brains. MOCAT not only satisfies the need for long-term tissue storage before performing volumetric multiplex imaging for research purposes but also has the potential to be used in human clinical examination.
Heart rate variability after video-assisted thoracoscopic surgery lobectomy
Authors: Frandsen Mikkel Nicklas , Huang Lin , Petersen René Horsleben , Foss Nicolai Bang , Mehlsen Jesper , Kehlet Henrik 
Published: November 2022

Abstract
Background: Heart rate variability (HRV) is a measurement of autonomic nervous system functioning and is potentially related to hypotension, postoperative atrial fibrillation, and orthostatic intolerance. However, there is a lack of knowledge on which specific time points and indices to measure. To improve future study design, there is a need for procedure-specific studies in an enhanced recovery video-assisted thoracic surgery (VATS) lobectomy setting, and for continuous measurement of perioperative HRV.
Methods: HRV was measured continuously from 2 days before until 9 days after VATS lobectomy in 28 patients. Patients filled out the Orthostatic Discriminant and Severity Scale 4 times during the study to describe the symptom burden possibly related to autonomic nervous system dysfunction.
Results: After VATS lobectomy, with median length of stay = 4 days, the standard deviation between normal-to-normal beats and the total power of HRV were reduced for 8 days during the night and day times, while low-to-high frequency variation and detrended fluctuation analysis were stable. An increase in orthostatic intolerance was potentially related to HRV. There was an increase in pain, weakness, and fatigue. Two patients developed postoperative atrial fibrillation
Conclusions: This is the first detailed study to show that HRV measures of total variability was reduced following fast-track VATS lobectomy, while other measures were more stable. Further, preoperative HRV measures showed circadian variation. Preoperative HRV as a risk factor for postoperative orthostatic intolerance and atrial fibrillation requires further study. The results demonstrate a valid design platform for future HRV studies in relation to postoperative outcomes.
Use of nutria fecal samples for the molecular identification of Strongyloides myopotami infection and the determination of nutria haplotypes in Japan
Authors: Makoto  , Yuga  , Atsushi  , Ryosuke  , Yuzuru  , Atsushi  , Tomoyuki  , Kazumi  
Published: November 2022

Abstract
Strongyloides myopotami is a zoonotic parasite that percutaneously causes a severe pruriginous rash. S. myopotami are frequently detected in nutrias in Japan. Identification of S. myopotami is commonly conducted based on the morphological characteristics of adult worms and cultured larvae after autopsy. However, to further our understanding of the parasitic infection in nutrias, it would be preferable to be able to noninvasively confirm S. myopotami infection using only a few grams of feces. In the present study, we attempted to identify S. myopotami using only DNA extracted from nematode eggs obtained from fecal samples collected after conventional fecal examinations. Among nine previously reported primer pairs targeting the 18S rRNA gene of Strongyloides spp., most could not specifically amplify sequences in PCR assays, and the sequences of amplicons could not be determined. We newly designed primers that successfully amplified partial sequences of the 18S rRNA gene in S. myopotami that could be sequenced. Additionally, haplotypes of nutrias could be determined using DNA extracted from a small amount of feces as a template for mitochondrial DNA-specific PCR followed by sequencing. Our simple protocol is expected to be useful in nationwide surveys for clarifying the risk of human infection.
IMpleMenting Effective infection prevention and control in ReSidential aged carE (IMMERSE): protocol for a multi-level mixed methods implementation study
Authors: Tropea Joanne , Peters Sanne , Francis Jill J , Bennett Noleen , Fetherstonhaugh Deirdre , Buising Kirsty , Lim Lyn-li , Marshall Caroline , Flynn Madelaine , Murray Michael , Yates Paul , Aboltins Craig , Johnson Douglas , Kwong Jason , Long Karrie , McCahon Judy , Lim Wen K 
Published: November 2022

Abstract
Background

Older people living in residential aged care facilities are at high risk of acquiring infections such as influenza, gastroenteritis, and more recently COVID-19. These infections are a major cause of morbidity and mortality among this cohort. Quality infection prevention and control practice in residential aged care is therefore imperative. Although appointment of a dedicated infection prevention and control (IPC) lead in every Australian residential aged care facility is now mandated, all people working in this setting have a role to play in IPC. The COVID-19 pandemic revealed inadequacies in IPC in this sector and highlighted the need for interventions to improve implementation of best practice.

Methods

Using mixed methods, this four-phase implementation study will use theory-informed approaches to: (1) assess residential aged care facilities’ readiness for IPC practice change, (2) explore current practice using scenario-based assessments, (3) investigate barriers to best practice IPC, and (4) determine and evaluate feasible and locally tailored solutions to overcome the identified barriers. IPC leads will be upskilled and supported to operationalise the selected solutions. Staff working in residential aged care facilities, residents and their families will be recruited for participation in surveys and semi-structured interviews. Data will be analysed and triangulated at each phase, with findings informing the subsequent phases. Stakeholder groups at each facility and the IMMERSE project’s Reference Group will contribute to the interpretation of findings at each phase of the project.

Discussion

This multi-site study will comprehensively explore infection prevention and control practices in residential aged care. It will inform and support locally appropriate evidence-based strategies for enhancing infection prevention and control practice.
Fluvial response to Quaternary Hydroclimate in Eastern Africa: Evidence from Gona, Afar
Authors: Stinchcomb Gary E. , Quade Jay , Levin Naomi E. , Iverson Nels , Dunbar Nelia , McIntosh William , Arnold Lee , Demuro Martina , Duval Mathieu , Grün Rainer , Zhao Jian-xin , White Marie , Rogers Mike , Semaw Sileshi 
Published: November 2022

Abstract
The Busidima Formation in the Afar region, Ethiopia, spans the Quaternary and records the cultural evolution of the genus Homo. Yet, the Middle Pleistocene to Holocene fluvial environments in which early humans lived are undersampled in eastern Africa. This paper examines the stratigraphy, geochronology and paleoenvironments of the newly designated Odele Member of the uppermost Busidima Formation (< 152 thousand years (ka)), which has received little attention despite being a critical period in the evolution of early Homo sapiens and its migration out of Africa. The Odele Member is 40–50 m thick and spans 151 to 7 ka, defined at the base by the widespread Waidedo Vitric Tuff (WAVT, 151 ± 16 ka modeled age and 95.4% C.I.). There are two prominent erosional unconformities in the Odele Member, a lower one after the WAVT deposition with a modeled 95.4% C.I. range of 124 − 97 ka; and an upper one involving widespread alluvial fan incision commencing between 13 and 10.6 ka. The uppermost Odele Member also contains black, organic-rich mats, redox features, reed casts, and semi-aquatic and aquatic gastropods marking wetter conditions during the terminal Pleistocene and Early Holocene. A black, fine-grained relict soil coeval with the Halalalee paleosol bounds the top of the Odele Member and has mollic and vertic properties, weathering since ~ 12 ka. These incision events and prominent paleosol development near/at the top of the Busidima Formation document Middle to Late Pleistocene Awash River incision to its present-day course. Paleo-rainfall estimates suggest that the Early Holocene-age Halalalee paleosol weathered under a climate with mean annual rainfall 10–15% higher than today. A compilation of radiocarbon ages from aquatic gastropods, carbonized wood and charcoal from the upper Odele Member shows wetter and possibly more vegetated conditions during late marine isotope stage (MIS) 3 and the African Humid Period (AHP) that are tightly coupled with precession-driven summer insolation maxima. The Odele Member revises upward the age of the Busidima Formation to 7 ka, showing that it spans into the Holocene and now includes Middle and Later Stone Age archaeological traditions.
Assessment of Thermal Performances of Walls Made of Rubberized Gypsum Composite in Arid Zones - Experimental Study and Simulation
Authors: Laoubi Hamza , Meddah Abdelaziz , Bederina Madani 
Published: November 2022

Introduction:
In this study, the thermal performance efficiency of buildings located in M’sila region (Algeria), which is considered as typical arid zone, was investigated. In its first part, the study focused on the laboratory evaluation of the thermomechanical properties of a gypsum mortar, in which rubber waste was incorporated by volume replacement of sand. The second part of study was to investigate the insulation performance of a typical wall subjected to arid climatic conditions, using numeric simulations.

Methods:
The thermal properties were measured using Transient Plane Source method (TPS), and then the Time-lag “ƒ” and decrement factor “φ” were calculated, for various wall configurations, using theoretical equations. The effect of various parameters was studied, including: wall thickness, inclusion of air space within the wall and application of surfacing materials.

Result:
The obtained results showed that when rubber content, in the composite, increases, the mechanical strength and the density decrease; whereas the insulating performances are considerably improved. The later were improved by more than 50% with 50% of rubber. The numerical simulations indicated that the thermal inertia characteristics [ƒ, φ] are improved when the thickness of the wall increased; moreover, more improvement was recorded (more than 38%% in time lag and more than 2h in decrement factor) when an air space was included within the wall and even when the wall surfaces are coated.

Conclusion:
The use of rubber waste as building materials, helps to regulate the temperature inside buildings, reduce the energy consumption, reduces the construction cost and protect the environment.
Mechanical and Chemical Behaviour of Water Treatment Sludge and Soft Soil Mixtures for Liner Production
Authors: Marchiori Leonardo , Studart André , Albuquerque Antonio , Pais Luis Andrade , Boscov Maria Eugênia , Cavaleiro Victor 
Published: November 2022

Background:
Clay-based and geosynthetic liners are generally used as hydraulic barriers in solid waste disposal facilities, mining tailing ponds, and soil-based wastewater treatment technologies, avoiding the leaching of hazardous compounds into subsoil and groundwater. Water treatment sludge (WTS) is a water treatment plant (WTP) residue which due to hydraulic properties seems to decrease the permeability in WTS:soil mixtures and may become an alternative material to produce sustainable waste-based liners.

Objectives:
This research aims to characterize and analyse physical, chemical and mechanical parameters of a WTS, a soft soil and four mixtures WTS:soil following 05:95%, 10:90%, 15:85%, 20:80% ratios, Thereby, evaluating the best ratio for producing waste-based liners for civil engineering applications.

Methods:
The geotechnical characterization was performed for particle size distribution, specific surface, specific gravity, Atterberg limits, and Normal Proctor compaction; chemical composition due to oxides analyses through X-ray fluorescence (XRF), mineralogical description by X-ray diffraction (XRD) and scanning electron microscope (SEM) with energy dispersive spectrometer (EDS) coupled for imaging; and mechanical behavior performing - –oedometric consolidation, consolidated undrained (CU) triaxial, and falling head permeability. Tests were conducted for all mixtures, the soil, and WTS, with pointed-out exceptions.

Results and Discussion:
The results showed that the fine-grained WTS filled the soil voids but rearranged soil particles, thus, compacted dry unit weight decreased with WTS addition, probably due to its chemical composition with high amounts of aluminium and silica. The compressibility of the compacted mixtures did not differ significantly compared to the soil, while the shear strength analysis demonstrated a reduction in cohesion and an increase in the effective internal friction angle proportional to WTS addition. Hydraulic conductivity increased with WTS until 10% of residue introduction, decreased for 15%, and continued to decrease for 20%, reaching optimum permeability at 15%.

Conclusion:
The incorporation of WTS can improve or just not interfere with soil’s properties to be used as liner material in solid wastes storage facilities, mining ponds and soil-based wastewater treatment technologies. Furthermore, 15% of WTS (15:85% mixture) incorporation provided the best results meeting the hydraulic conductivity requirement for liner materials, i.e., equal, or lower than 10-9 m/s. The reuse of WTS for this purpose would allow producing a new added-value material in the scope of circular economy.