bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of drug-resistant phenotype, drug resistance mechanism, and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in Dongguan, China
Authors: Guo Zhusheng , Lv Fei , Xie Shujin , Huang Ya , Lin Sisi , Xu Baohua , Feng Jianbo , Feng Sen , He Fen , Zhou Mouqing , Gong Chengfang 
Published: July 2022

Abstract
In China, the genetic environment of KPC-2 in Zhejiang and Taiwan is type B1, while Dongguan seems to be different. A total of 131 Carbapenem-resistant Enterobacteriaceae (CRE) strains were detected from the inpatients of 13 hospitals in Dongguan from January 2016 to December 2018, including 79 Klebsiella pneumoniae (60.31%), 21 Escherichia coli (16.03%), and 12 Enterobacter cloacae (9.16%). Intensive Care Unit (ICU) was the main clinical department with detectable CRE isolates. Sputum, urine, and wound secretion were the top three samples with detectable CRE. Results of drug resistance assessment revealed high drug resistance of CRE to clinical common antibacterial agents but low drug resistance to amikacin only. Additionally, KPC-2 (57 strains, 54.81%), NDM-1 (7 strains, 6.73%), and NDM-5 (2 strains, 1.92%) carbapenemases were detected in 104 CRE strains (Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae). ST11-type (49 strains, 62.03%) was the main detectable MLST in 79 carbapenem-resistant Klebsiella pneumoniae (CRKP) strains, followed by ST1-type (25 strains, 31.65%). The porins (ompK35, ompK36, and ompK37) showed high proportions of mutations (94%, 97.47%, and 100%, respectively). The dominant genetic environment of the blaKPC-2 gene was B1-type mutant (38 strains, 48.10%), followed by A-type mutant (14 strains, 17.72%). A large number of clinical CRE isolates in Dongguan exhibited strong drug resistance. Among them, ST11-type was the most prevalent in CRKP, most of which harbored KPC-2-type carbapenemase, indicating that the genetic environment of the blaKPC-2 gene is B1-type mutant and the blaKPC-2 is mainly spread through plasmids. Moreover, the proportion of the porins mutations was extremely high. In general, the prevalence of CRKP in Dongguan is different from that in other area.
Real-World Study of HIV Patients Starting Antiretroviral Treatment With Boosted Protease Inhibitors in the Integrase Inhibitors Era
Authors: Pardo Ana Arancón , Salillas Carmen Mateos , Jiménez-Nácher Inmaculada , García Juan González , Ambrosio Alicia Herrero 
Published: July 2022

Abstract
Background
Boosted-protease inhibitors (b-PIs) are not recommended for initial therapy in HIV patients, but there is still a cohort of patients who could benefit from this antiretroviral treatment (ART). The purpose of this study was to analyze the profile of HIV patients who receive for the first time an ART containing two nucleoside reverse transcriptase inhibitors (NRTIs) and one b-PI. Efficacy and safety of this treatment, as well as the reasons for starting and changing it, were evaluated.
Methods
An observational, retrospective study was performed on the use of b-PIs in adult HIV patients. Individuals who started treatment with two NRTIs (emtricitabine and tenofovir alafenamide) and one b-PI (darunavir combined with cobicistat or ritonavir) between October 2019 and September 2021 were eligible for our study. This study was retrospectively registered by local Ethics Committee of our hospital (protocol number: PI-5066) on January 13th 2022.
Results
Overall, 52 patients started ART with two NRTIs plus one b-PIs. Only 8% of them were naïve, 21% received already two NRTIs plus a b-PI and 71% received other regimens. Reasons to start PIs were adverse effects to previous treatment and previous treatment failure. Most patients continued PIs treatment during the 2 years follow-up period and only six of them withdrew it.
Conclusions
This study analyzes the subgroup of patients that could benefit from treatment with b-PIs in the current era of integrase inhibitors. Even though its use is minority, its efficacy is high especially in patients with toxicity, therapeutic failure or poor adherence to other ARTs.
Land-Use Change in Wetlands: A Multi-Disciplinary Study in Iran
Authors: Damaneh Hadi Eskandari , Damaneh Hamed Eskandari , Zehtabian Behnaz , Rezai Marzieh , Sardooei Mohsen Adeli , Tiefenbacher John P. 
Published: July 2022

Abstract

Land-use changes are a primary cause of global environmental change. Land use is the management of land cover through human intervention. Study of land-use change in wetlands is largely overlooked as an estimated 30 to 90 % of the world’s wetlands have been destroyed or strongly modified. Therefore, supporting wetland conservation is an urgent priority in three high-level global agendas of 2030. While many factors like global warming and changing climates are key to wetland degradation today, overexploitation by agriculture is the most important destroyer of wetlands in countries like Iran. This study examines the case of the Bakhtegan and Tashak wetland in Iran to determine the factors that influence farmers’ attitudes and behaviors toward wetland conservation. This is done in two phases. The first phase uses remote sensing and GIS to analyze land use changes from 2000 to 2020. The second phase involves surveying farmers to examine the factors behind their intended willingness to participate or support conservation. The data were analyzed using ENVI 5.3, GIS 10.3, SPSS 20, and AMOS 20. The results of phase one reveal a significant increase of bare lands around the wetlands. The survey shows that attitude and subjective norms had positive influences on farmers’ behavioral intentions toward wetland conservation to a statistically significant extent.
Prediction of exercise-induced desaturation in COPD patients without resting hypoxemia: a retrospective study
Authors: Yang Lulu , Qumu Shiwei , Shi Minghui , Situ Xuanming , He Jiaze , Yang Ting 
Published: July 2022

Abstract
BackgroundThere is no universally accepted criterion for assessing exercise-induced desaturation (EID). The purpose of this study is to compare the two methods regularly used methods for determining EID in COPD patients,as well as to explore the risk factors and predictors related to EID.MethodsThe 6MWT was performed with continuous SpO2 monitoring on patients with stable COPD. Using two methods (method A: "SpO2rest-SpO2min≥ 4% and/or SpO2min< 90%", method B: "SpO2rest-SpO2end≥ 4% and/or SpO2end< 90%") as EID determination criteria to assess the incidence of EID. The differences and consistency of the two methods are compared. Moreover, we collected data through the pulmonary function test, mMRC dyspnea score, COPD assessment test, BODE index and CT-defined emphysema. Univariate and multivariate logistic regression analyses were used to identify factors affecting the EID. For the parameters that predict EID in 6MWT, a receiver operating characteristic (ROC) curve analysis was employed.ResultsThe analysis included 124 patients. The overall incidence of EID was 62.1% by using method A as the criterion and 51.6% by method B. All of the EID patients found by method B were included in the EID patients identified by method A, as well as 13 new-EID patients. The difference in diagnostic outcomes between the two approaches was not statistically significant (P>0.05), but they were in excellent agreement (Kappa=0.807, P=0.001). Logistic regression analyses found that DLCO SB% pred, DLCO/VA% pred, CAT score, mean density, PD15, emphysema volume and %LAA were significant determinants of the EID. For predicting EID, the ROC analysis produced AUC and cutoffs of 0.689 and 50.45% (DLCO SB% pred), 0.707 and 75.0% (DLCO/VA% pred), 0.727 and 15 points (CAT score), 0.691 and -955.00HU (PD15), 0.671 and -856.46HU (mean density), 0.668 and 338.14ml (emphysema volume) and 0.656 and 7.63% (%LAA), respectively.ConclusionsTwo methods evaluating EID in this research are in a good agreement, method A can find more EID patients by focusing on SpO2min. When conditions are constrained, it is also sufficient to assess EID in COPD patients by method B. In terms of the predictors of EID, DLCO SB% pred, DLCO/VA% pred, CAT score and CT-defined emphysema are all statistically significant test variables to determine EID.
Causal analysis of trade openness, government expenditures and economic growth in Nigeria (1980-2020): Recalling economic policy corrective actions
Authors: Zaria Yusuf Bala 
Published: July 2022

Abstract
This research investigates the causality relationship between trade openness, government expenditures and investment in infrastructure's relative advantage of economic growth for recalling economic policy corrective actions. Based on the theory of comparative advantage and elementary neoclassical trade model that concentrating on different productivity would improve trade and development potentials of the country. It employs Johansen cointegration and Granger causality techniques to examine the comparative advantage theory and assess the short-run and long-run relationship. Annual time-series data from 1980 to 2020 shows the relationship between trade openness, government expenditures on education and investment in infrastructure are statistically significant for economic growth in Nigeria. There is a cointegration relationship among the indicators with relative advantage, and Granger causality reveals short-run. There is a bidirectional relationship between trade openness and economic growth. While a unidirectional relationship between trade openness and infrastructural development on economic growth. Hence, this research realize that human capital development does not affect economic growth. The policy recommendations imply that all the indicators are solid macroeconomic factors following the empirical analysis for emphasizing the relative advantage of trade openness in Nigeria. The policymakers should consider trade diversification through development of infrastructure, human capital development to increase productivity toward economic growth.
What is the impact of COVID-19 pandemic, season and temperature on prevalence of childhood diarrhoeal cases and treatment in India during 2018-2021– A 41 months cross-sectional research study?
Authors: Kumar Piyush , Anupama Advocate 
Published: July 2022

Abstract
Globally diarrheal illness is the second leading reason behind death in kids underneath 5 years accounting for 525 000 kids death annually, which can be treated and prevented if timely interventions are applied as well as can be prevented through safe drinking-water with adequate sanitation and hygiene. Global prevalence of childhood diarrhoea is about 1.7 billion cases per annum. SARS-CoV utilize the Angiotensin-converting enzyme 2 (ACE2) with the serine protease TMPRSS2 for S protein priming. ACE2 and TMPRSS2 are expressed in lung, as well as small intestinal epithelia, added to this the ACE2 is expressed in the oesophagus, liver, and colon; SARS-CoV-2 binds strongly with ACE2 (10–20 times) compared with other SARS-CoV. The purpose of this research is to examine the epidemiology of childhood diarrheal events during COVID-19-period and comparing it with the pre-pandemic period of 2018–2019 as well as monthly-seasonal-temperature variations during different months of pre-pandemic and pandemic period associated diarrhoea to identify any changes in the usual seasonal pattern of childhood diarrheal events. A total of 11171113 eligible childhood diarrhoea (0–5 years) and 1704819 Childhood diarrhoea treated in Inpatients (0–5 years) were analyzed during the 41 month study period. A total of 11171113 (mean-272466.2; [95% Conf. Interval means] 250375.4- 294556.9) childhood diarrhoea (mean-; [95% Conf. Interval means]) (0–5 years), 1704819 (mean 41580.95-; [95% Conf. Interval means − 36458.75- 46703.15]) childhood diarrhoea treated in Inpatients (0–5 years), 7603860 (mean 185460-; [95% Conf. Interval means − 159578.8- 211341.2]) were included in this study on an all-India basis. The 41 months of study when grouped into two groups as pre-pandemic era and pandemic era shows that the Monthly /seasonally Prevalence of Childhood diarrhoea (0–5 years) were MAX in July 2019 monsoon season during pre-pandemic period with 418722 cases ([95% CONF. INTERVAL] 299758.7- 338763.3; STD. ERR.- 9427.519; MEAN-319261; STD. DEV- 46185.22; and MIN-261319 in December 2019, post monsoon season, See table- 1, 3, and 4; figure-5 and 6. During the COVID-19 pandemic period Monthly /seasonally Prevalence of Childhood diarrhoea (0–5 years) were MAX in February 2020 winter season during pre-pandemic period with 284075 cases ([95% CONF. INTERVAL] 188170.3–224635.3; STD. ERR.- 8600.616; MEAN-206402.8; STD. DEV- 35461.25; and MIN-158007 in April 2020.
The prevalence of smartphone addiction and associated factors among Zimbabwean undergraduate students: a cross-sectional study
Authors: Muchemwa Sidney , Moyo Pamela I.A. , Paradza Blessing , Chipunza Omega , Dambi Jermaine M. , Chibanda Dixon , Kaiyo-Utete Malinda 
Published: July 2022

Abstract
Objective: Smartphones are an invaluable daily tool, with over a third of the world having mobile access to the internet. There has been a concurrent upsurge in smartphone use among university students, and despite these benefits, excessive use of smartphones is highly prevalent. Smartphone addiction/problematic mobile phone use is a behavioural addiction that leads to severe impairment and distress. The ongoing COVID-19 pandemic has led to an exponential increase in smartphone usage, further exacerbating the burden of smartphone addiction. This study aims to determine the prevalence of smartphone addiction and its associated risk factors among Zimbabwean university students. Data were collected from 380 undergraduate students and analyzed through descriptive statistics, bivariate statistics, and binary logistic regression.Results: The prevalence of smartphone addiction in our study population was 54.2%. After controlling for potential covariates, social media usage (OR 2.7: CI 1.2 – 5.9), using a smartphone for entertainment (OR 2.2: CI 1.2 – 4.0), the experience of coronavirus-induced anxiety (OR 1.1: CI 1.0 – 3.2) and an experience of an adverse event (OR 1.8) were associated with increased smartphone addiction. The use of smartphones for academic work was protective against smartphone addiction (OR .38: CI .19 - .77).
Association of COVID-19 with Diabetes: A Systematic Review and Meta-Analysis
Authors: Ssentongo Paddy , Zhang Yue , Witmer Lisa , Chinchilli Vernon M. , Ba Djibril M. 
Published: July 2022

Abstract
Emerging evidence suggests that long COVID-19 may lead to a wide range of post-acute sequelae outcomes, including new onset of diabetes. The aim of this meta-analysis was to estimate the incidence of newly diagnosed diabetes in survivors of coronavirus disease-2019 (COVID-19). Multiple electronic databases (MEDLINE, Scopus, Cochrane Central Register of Controlled Trials and the World Health Organization Global Literature on Coronavirus Disease) and clinical trial registries were searched to June 25, 2022, for studies reporting the association of COVID-19 and diabetes. Two investigators independently assessed studies for inclusion. Risk of bias was assessed using the Newcastle-Ottawa Scale. We estimated the effect of COVID-19 on incident diabetes by random-effects meta-analyses using the generic inverse variance method. We identified 5 eligible studies consisting of 1,130,773 COVID-19 patients and 16,630,187 controls. Median age was 43 years (interquartile range, 1QR: 20–55), and 34.8 % were female. COVID-19 was associated with a 74% higher risk of incident diabetes (risk ratio, 1.74; 95% CI: 1.37; 2.21). The average risk of bias assessment was 7.5. In this systematic review and meta-analysis, COVID-19 was associated with higher risk for developing new onset diabetes among survivors. Active monitoring of glucose dysregulation after recovery from severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection is warranted.
Study of the functional properties of a fermented milk product based on mare’s milk
Authors: Simonenko E. S. , Kupaeva N. V. , Simonenko S. V. , Manuilov B. M. 
Published: July 2022

In the last few years, there has been a growing interest in the use of mare’s milk for human nutrition as well as in the use of this product for treatment and prevention of diseases such as hepatitis, chronic pathologies of the gastrointestinal tract, tuberculosis and others. The beneficial properties of mare’s milk are determined first of all by its significant differences from ubiquitous cow’s milk. Many studies show that consumption of fermented milk products offers various advantages for health and the use of probiotic cultures in the composition of starters for fermented milk products allows imparting several functional properties to a product. However, kumis is the only available fermented milk product from mare’s milk on the market. Therefore, the development of new fermented milk products based on mare’s milk is topical and highly demanded. Fermented milk products were developed based on mare’s milk and mare’s milk with addition of cow’s milk using the association consisted of the starter for yogurt and the probiotic strain L. rhamnosus F. The aim of the work was to determine functional properties of fermented milk products based on mare’s milk and mare’s milk with addition of cow’s milk by in vitro methods. It was proved that the products had the high total antioxidant capacity, antiradical and antimicrobial activities as well as the low value of atherogenicity (1.22); the ratio of hypocholesterolemic fatty acids to hypercholesterolemic fatty acids is 1.40.
Grocery Delivery to Support Healthy Weight Gain Among Pregnant Young Women With Low Income: Protocol for a Randomized Controlled Trial
Authors: Waselewski Marika , Plegue Melissa , Sonneville Kendrin , Resnicow Ken , Ghumman Aisha , Ebbeling Cara , Mahmoudi Elham , Sen Ananda , Wolfson Julia A , Chang Tammy 
Published: July 2022

Background
Excessive weight gain during pregnancy is associated with complications for both the mother and her infant including gestational diabetes, hypertensive disorders, operative delivery, and long-term obesity. A healthy diet during pregnancy promotes healthy gestational weight gain and determines fetal epigenetic programming in infants that impacts risk for future chronic disease.

Objective
This project will examine the impact of grocery delivery during pregnancy on the weight, diet, and health outcomes of young pregnant women and their infants.

Methods
A three-arm randomized controlled trial design will be performed. A total of 855 young pregnant women, aged 14-24 years, from across the state of Michigan will be enrolled and randomized equally into the three study arms. Participants in arm one (control) will receive usual care from the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC); arm two will receive WIC plus biweekly grocery delivery; and arm three will receive WIC plus biweekly grocery and unsweetened beverage delivery. Weight will be assessed weekly during pregnancy, and total pregnancy weight gain will be categorized as above, below, or within guidelines. Additionally, dietary intake will be assessed at three time points (baseline, second trimester, and third trimester), and pregnancy outcomes will be extracted from medical records. The appropriateness of pregnancy weight gain, diet quality, and occurrence of poor outcomes will be compared between groups using standard practices for multinomial regression and confounder adjustment.

Results
This study was funded in April 2021, data collection started in December 2021, and data collection is expected to be concluded in 2026.

Conclusions
This study will test whether grocery delivery of healthy foods improves weight, diet, and pregnancy outcomes of young moms with low income. The findings will inform policies and practices that promote a healthy diet during pregnancy, which has multigenerational impacts on health.

Trial Registration
ClinicalTrials.gov NCT05000645; https://clinicaltrials.gov/ct2/show/NCT05000645

International Registered Report Identifier (IRRID)
DERR1-10.2196/40568
The effect of the performance of the audit committee, internal audit, and manager religion on the implementation of good corporate governance and their implications on fraud
Authors: Friyani Rita , Haryadi Haryadi , Afrizal Afrizal , Arum Enggar Diah Puspa 
Published: July 2022

The main objective of this research is to analyze the performance of the audit committee, internal audit, and religiosity of the manager on the implementation of good corporate governance (GCG) and its implication for fraud. The study was conducted at State-owned enterprises (SOEs) in Indonesia. The population of this research is all SOEs in Indonesia, and the number of samples is 89 SOEs (based on the Slovin formula). The sampling method used a simple random sampling technique. The research data was obtained by submitting a list of questions to the selected respondents. Respondents consist of the chairman of the audit committee or members of the audit committee, the head of internal audit or members of internal audit, the corporate secretary, and the finance director (financial manager). The data were analyzed using the SEM-PLS model. The research proves that the performance of audit committees and internal audits affects the implementation of GCG, while the religiosity of managers does not affect the implementation of GCG. The research also proves that the performance of the audit committee and the implementation of GCG affect fraud, while internal audit and religiosity of managers do not affect fraud
Reconocimiento NIIF: el capital intelectual en el contexto de las instituciones de educación superior
Authors: Gutiérrez Rivera Dina L. , Vega Gaitán Belky F. , González Pulido Angélica S. 
Published: July 2022

Con la llegada de la globalización surgieron nuevos conceptos, uno de ellos es el capital intelectual, definido como un activo intangible que se encarga de aportar valor a la empresa por medio de criterios como la investigación, la innovación y el desarrollo, a través de conocimientos que se van adquiriendo en las actividades propias de una compañía o asociación. De otra parte, siendo una fuente de intangibles, las universidades son consideradas como empresas sociales, especialmente porque conforman un conjunto de información, servicios, bienes, entre otros, en procura de mayores beneficios comunitarios. Por tal motivo, el alcance de esta investigación se centra en contribuir con un proceso de reconocimiento del capital intelectual bajo la normativa NIIF dentro de las instituciones de educación superior de la ciudad de Villavicencio.

Para efectos de esta investigación, se incorporaron instrumentos de recolección de información, ficha de caracterización, entrevistas y encuestas aplicadas a la unidad de análisis, todo esto con la finalidad de lograr un desarrollo armónico en torno al problema planteado, principalmente en procura de la integración de conceptos contables con el desarrollo del capital intelectual en los espacios de formación universitaria.
Tax Research by Bad Example: A Twist on the Classic Case
Authors: Esdale Michaele Morrow , Franklin Mitchell 
Published: July 2022

ABSTRACT
Traditional tax research cases provide students a set of facts and then ask them to conduct research and write a memo summarizing those findings. While this method exposes students to both research and writing, it does not expose students to the review process that is integral to a professional career in accounting. Students are given a poorly written tax research memo and client email that were completed by a fictional colleague, then asked to play the role of an experienced associate in a public accounting firm and to review the documents to identify errors in both technical content and writing. Acting as an associate, the student provides written feedback to the colleague, but then must write a correct tax research memo and client letter. Feedback from students shows that this exercise was successful in developing skills and providing a positive learning experience. This case is adaptable for undergraduates or graduates.
JEL Classifications: H2; J4; K3.