bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Dimensi Servqual Terhadap Loyalitas Tamu Bossotel Inn, Bangkok Dengan Kepuasan Sebagai Variabel Intervening
Authors: Manggali Galuh Putri , Sulaksono Hary 
Published: February 2022

This research aims to analyze servqual dimension that consisting of tangible, empathy, reliability, responsiveness, and assurance towards guest loyalty at Bossotel Inn, Bangkok, with satisfaction as an intervening variable.
This research method uses quantitative descriptive research, data collection techniques using purposive sampling by distributing 100 questionnaires to the guest of Bossotel Inn, Bangkok, the analysis method used is path analysis using SPSS version 20 and the sobel test calculator to test hypotheses.
The results of this research indicate that: 1) reliability and assurance variable have a direct effect on Bossotel Inn, Bangkok guest satisfaction. While tangible, empathy, and responsiveness variable do not have direct effect, 2) empathy and responsiveness variable have direct effect on Bossotel Inn, Bangkok guest loyalty, while tangible, reliability, and assurance variable have no effect, 3) hotel guest satisfaction variable has a direct effect on Bossotel Inn, Bangkok guest loyaltsy, and the last, 4) hotel guest satisfaction cannot be a mediate the relationship between tangible, empathy, reliability, responsiveness, and assurance towards guest loyalty at Bossotel Inn, Bangkok, Thailand.
EXPERIENCIA DE CARIES EN ESCOLARES DE 12 AÑOS DE LLACAO CUENCA
Authors: LOARTE MERINO GUISELA JANETH 
Published: February 2022

Objetivo: Determinar el Índice CPOD promedio en escolares de 12 años en la parroquia Llacao perteneciente al Cantón Cuenca en el año 2016. Materiales y métodos: Estudio descriptivo, observacional, clínico, en 75 escolares de la parroquia Llacao de la ciudad de Cuenca, se utilizaron los criterios del índice CPOD recomendados por la OMS para el diagnóstico de caries. Resultados: El CPOD promedio de la muestra estudiada fue de 3,7 D.E. (3,2) que se considera como un nivel moderado. La prevalencia de caries dental en la población estudiada es de 76%
LA FARMACORRESISTENCIA MICROBIANA: UNA NUEVA PERSPECTIVA
Authors: RADAX JOHANN FRANZ 
Published: February 2022

Esta revisión literaria analiza si el abuso de los antibióticos y el desarrollo resultante de resistencias microbianas constituyen la realidad de nuestro presente o si vivimos en el mundo “feliz” presentado en los comerciales. Se realizó una búsqueda inicial por clústeres en el internet y subsiguientes búsquedas adicionales según el principio de bola de nieve. El uso de los antibióticos ha aumentado en las últimas décadas. En los EEUU el 80% de estas substancias se destina a la agricultura y ganadería, especialmente para fines profilácticos y como promotores de crecimiento. Mediante ejemplos se comprueba que no existe unaseparación real entre los antibióticos para el uso veterinario y aquellos para el uso humano. Varios estudios internacionales (Europa, Norteamérica, Brasil) determinaron la presencia de bacterias multirresistentes en animales de granja y personas expuestas. Una prohibición en la Unión Europea del uso de antibióticos para la profilaxis y la promoción del crecimiento en la ganadería no surtió efectos satisfactorios. Se informa el problema de los antibióticos en productos alimenticios y en el suelo y los resultados de estudios locales sobre la contaminación de alimentos con antibióticos y gérmenes resistentes. Las grandes farmacéuticas abandonan el desarrollo de nuevos antibióticos por no constituir un modelo económico atractivo. Se critica eluso indiscriminado de “antibióticos de reserva” en la producción ganadera. El uso de los antibióticos en la odontología es sometido a una evaluación. Se presenta la lista de recomendaciones emitida por la Sociedad Americana de Enfermedades Infecciosas y se amplía la lista por varios puntos para adaptarla a la realidad del Ecuador. Se advierte de que se está agotando el tiempo que queda para actuar.
GUÍA PARA AUTORES Y NORMAS DE PUBLICACIÓN
Authors: OActiva Revista 
Published: February 2022

La revista O-Activa de la carrera de Odontología fue creada en el año 2015; indexada en LATINDEX- CATÁLOGO v2.0
en el año 2018 con un puntaje 38/38, pertenece a la Unidad Académica de Salud y Bienestar de la Universidad Católica
de Cuenca. Es un órgano de difusión científica que pretende divulgar todo tipo de trabajos con el objetivo fundamental
de transmitir el conocimiento dentro del área odontológica, en el cual se incluyen temas de actualidad y relevancia como:
Epidemiología, Operatoria Dental, Materiales dentales, Radiología Maxilofacial, Cirugía Bucal y Maxilofacial, Ortodoncia
y Ortopedia Maxilar, Odontopediatría, Periodoncia e Implantología, Endodoncia, Rehabilitación Oral, Patología Bucal,
Odontología Forense, Salud Pública, entre otros tantos aspecto médicos relacionados con la Odontología. La revista está
dirigida a todos los investigadores, docentes, profesionales y estudiantes no solo de la especialidad, sino también del área de
las Ciencias de la Salud en general. De esta forma se contribuye al fortalecimiento, discusión e intercambio de conocimientos,
proporcionando con ello información que sirva de base para el desarrollo profesional y la formación continua. La presente
guía consta de cuatro partes: tipología de artículos a publicar, requisitos para preparar un manuscrito, instrucciones para la
preparación de las secciones del manuscrito y proceso de evaluación por pares.
Immunological characteristics of human umbilical cord mesenchymal stem cells after hepatogenic differentiation
Authors: Yin Yanfeng , Hu Zongqiang , Guan Zheng , Lv Sha , Wang Yiyin , Su Wenjun , Yan Chuntao , Wang Yiting , Ma Li , Jiang Jie , Feng Shiming , Li Li 
Published: February 2022

BACKGROUND: Acute liver failure is one of the most intractable clinical problems. The use of bioartificial livers may solve donor shortage problems. Human umbilical cord mesenchymal stem cells (hUCMSCs) are an excellent seed cell choice for artificial livers because they change their characteristics to resemble hepatocyte-like cells (HLCs) following artificial liver transplantation. OBJECTIVE: This study aimed to determine whether the immunological characteristics of hUCMSCs are changed after being transformed into hepatocyte-like cells. METHODS: HUCMSCs were isolated by the adherent method. The following hUCMSC surface markers were detected using flow cytometry: CD45, CD90, CD105, CD34, and octamer-binding transcription factor 4 (OCT-4). Functional detection of adipogenic differentiation was performed. The hUCMSCs were cultured in complete medium (control group) or induction medium (induction group), and flow cytometry was used to detect cell surface markers. Peritoneal lavage fluid was collected after intraperitoneal injection of 1 × 106 cells/mouse over 40 minutes. The leukocyte count, labeled CD45, CD3, CD4 and CD8 antibodies, and flow detection of T lymphocyte subsets were determined using the peritoneal lavage fluid. RESULTS: Using phenotypic and functional identification, hUCMSCs were successfully isolated using a two-step induction method. The surface markers of the hUCMSCs cells changed after HLC induction. In vivo immune results showed that hUCMSCs and HLsC induced leukocyte production. CONCLUSION: Hepatic induction of hUCMSCs changes their cell surface markers. Both HLCs and hUCMSCs cause leukocytosis in vivo, but the immune response induced by HLCs is slightly stronger.
Human-derived decellularized extracellular matrix scaffold incorporating autologous bone marrow stem cells from patients with congenital heart disease for cardiac tissue engineering
Authors: Gao Liping , Li Xuexia , Tan Rubin , Cui Jie , Schmull Sebastian 
Published: February 2022

BACKGROUND: Stem cells are used as an alternative treatment option for patients with congenital heart disease (CHD) due to their regenerative potential, but they are subject to low retention rate in the injured myocardium. Also, the diseased microenvironment in the injured myocardium may not provide healthy cues for optimal stem cell function. OBJECTIVE: In this study, we prepared a novel human-derived cardiac scaffold to improve the functional behaviors of stem cells. METHODS: Decellularized extracellular matrix (ECM) scaffolds were fabricated by removing cells of human-derived cardiac appendage tissues. Then, bone marrow c-kit+ progenitor cells from patients with congenital heart disease were seeded on the cardiac ECM scaffolds. Cell adhesion, survival, proliferation and cardiac differentiation on human cardiac decellularized ECM scaffold were evaluated in vitro. Label-free mass spectrometry was applied to analyze cardiac ECM proteins regulating cell behaviors. RESULTS: It was shown that cardiac ECM scaffolds promoted stem cell adhesion and proliferation. Importantly, bone marrow c-kit+ progenitor cells cultured on cardiac ECM scaffold for 14 days differentiated into cardiomyocyte-like cells without supplement with any inducible factors, as confirmed by the increased protein level of Gata4 and upregulated gene levels of Gata4, Nkx2.5, and cTnT. Proteomic analysis showed the proteins in cardiac ECM functioned in multiple biological activities, including regulation of cell proliferation, regulation of cell differentiation, and cardiovascular system development. CONCLUSION: The human-derived cardiac scaffold constructed in this study may help repair the damaged myocardium and hold great potential for tissue engineering application in pediatric patients with CHD.
Serological cancer-associated protein biomarker levels at bowel endoscopy: Increased risk of subsequent primary malignancy
Authors: Piper Thomas B. , Nielsen Hans J. , Christensen Ib Jarle 
Published: February 2022

BACKGROUND: It was previously shown in three subpopulations that subjects not identified with colorectal cancer (CRC) at bowel endoscopy, but with increased serological cancer-associated protein biomarker levels had an increased risk of being diagnosed with subsequent malignant diseases. Objective: The aim of the present study was to perform a pooled analysis of subjects from the three subpopulations and subsequently validate the results in an independent study. The study population denoted the training set includes N = 4,076 subjects with symptoms attributable to CRC and the independent validation set N = 3,774 similar subjects. METHODS: Levels of CEA, CA19-9, TIMP-1 and YKL-40 were determined in blood samples collected prior to diagnostic bowel endoscopy. Follow-up of subjects not diagnosed with CRC at endoscopy, was ten years and identified subjects diagnosed with primary intra- or extra-colonic malignant diseases. The primary analysis was time to a newly diagnosed malignant disease and was analyzed with death as a competing risk in the training set. Subjects with HNPCC or FAP were excluded. The cumulated incidence was estimated for each biomarker and in a multivariate model. The resulting model was then validated on the second study population. RESULTS: In the training set primary malignancies were identified in 515 (12.6%) of the 4,076 subjects, who had a colorectal endoscopy with non-malignant findings. In detail, 33 subjects were subsequently diagnosed with CRC and 482 subjects with various extra-colonic cancers. Multivariate additive analysis of the dichotomized biomarkers demonstrated that CEA (HR = 1.50, 95% CI:1.21–1.86, p < 0.001), CA19-9 (HR = 1.41, 95% CI:1.10–1.81, p = 0.007) and TIMP-1 (HR = 1.25 95% CI: 1.01–1.54, p = 0.041) were significant predictors of subsequent malignancy. The cumulated incidence at 5 years landmark time was 17% for those subjects with elevated CEA, CA19-9 and TIMP-1 versus 6.7% for those with low levels of all. When the model was applied to the validation set the cumulated 5-year incidence was 10.5% for subjects with elevated CEA, CA19-9 and TIMP-1 and 5.6% for subjects with low levels of all biomarkers. Further analysis demonstrated a significant interaction between TIMP-1 and age in the training set. The age dependency of TIMP-1 indicated a greater risk of malignancy in younger subjects if the biomarker was elevated. This observation was validated in the second set. CONCLUSION: Elevated cancer-associated protein biomarker levels in subjects with non-malignant findings at large bowel endoscopy identifies subjects at increased risk of being diagnosed with subsequent primary malignancy. CEA, CA19-9 and TIMP-1 were significant predictors of malignant disease in this analysis. TIMP-1 was found dependent on age. The results were validated in an independent symptomatic population.
SIFAT FISIK, KIMIA DAN ORGANOLEPTIK PERMEN JELLY TOMAT DENGAN VARIASI JENIS GULA DAN BAHAN PEMBENTUK GEL
Authors: Handayani Catur Budi , Hartati Sri , Afriyanti Afriyanti 
Published: February 2022

The purpose of this study was to determine the characteristics of the physical, chemical characteristic (reducing sugar content) and organoleptic characteristic (taste, preference) tomato jelly with various types of sugar (glucose, dextrose and sucros and gelling agents (agar and jelly powder) are added. The study used a factorial design. The results showed that the water content of the tomato jelly candy ranged from 7.4 to 10.03% and there was no significant difference between all treatments. The reducing sugar content ranged from 0.59 to 3.46% and there was a significant difference between candy using dextrose and other types of sugar. The organoleptic characteristic of taste showed that the most preferred tomato jelly candy was candy made using sucrose and agar with a score of 3.03 (delicious) and the least preferred was jelly candy with dextrose agar. The overall organoleptic test of liking showed that the most preferred candy was candy made with glucose agar and the least preferred candy was candy made using dextrose agar. Keywords: agar, jelly powder, tomato jelly candy, sugar
Smart Learning Torso Berbasis IoT: Tool Cerdas Pembelajaran Mandiri untuk Menumbuhkan Self-Effycacy Anak Berkebutuhan Khusus
Authors: Pratiwi Umi 
Published: February 2022

Anak berkebutuhan khusus (ABK) merupakan anak yang memiliki keunikan pada jenis dan karakter tertentu. Anak-anak ABK yang kehilangan salah satu indra tubuhnya akan menggunakan sisa indra yang ada, hal ini menyebabkan terganggu fungsi penerimaan informasi sebagai kebutuhan pengetahuannya. Mereka memerlukan perhatian khusus untuk hidup seperti anak-anak normal lainnya seperti pemenuhan kebutuhan informasi untuk mendapatkan penghidupan yang layak. Kehidupan yang layak salah satunya pemenuhan pendidikan agar anak-anak ABK dapat menikmati pendidikan yang sama dengan anak normal lainnya sesuai dengan kebutuhannya. Oleh karena itu untuk memenuhi kebutuhan anak berkebutuhan khusus di SLB terpadu Muhammadiyah Purworejo di kembangkan media pembelajaran smart learning torso sebuah media pembelajaran media cerdas dalam bentuk torso alat peraga bilogi organ tubuh manusia untuk meningkatkan pengetahuan pemahaman materi IPA Biilogi dan kemandirian siswa. Pembuatan media pembelajaran menggunakan model pengembangan ADDIE dimulai dari proses analisis kebutuhsn, tahap desain, tahap pengembangan, tahap implementasi, dan tahap evaluasi. Media yang dihasilkan menghasilkan kemampuan kognitif sebesar 78,3 %, kemampuan afektif sebesar 80%, dan kemampuan psikomotorik sebesar 86,25%. Adanya 3 kemampuan ini siswa paling tidak dapat menunjukkan nama-nama organ utama tubuh manusia dan letaknya.
Data Format and Interface Design in Digital Identity Applications Using WSO2
Authors: Winata Yuki Indragiri , Hermawaty Hermawaty , Mujib Muh 
Published: February 2022

This study aims to upgrade the application login system in STMIK "AMIKBANDUNG", from some problems that exist in a regular login system and with the development of an information system that requires STMIK "AMIKBANDUNG" to follow its development, not only various applications but companies are required to improve data security on the application login system. In the draft in this study proposes a single entry system (Single Sign On). By using this single login system, users only need to remember one user name and password to enter in various applications in the organization or company. In this study using open source WSO2 IS, and in the database system in WSO2 IS there is an embedded database system that is H2 database, in addition to H2 database, WSO2 IS provides a place for other database systems such as MYSQL. So in one identity provider this contains two database systems. And the results of the application of MYSQL database in this research allows WSO2 IS users to develop in various protocols in WSO2 IS, and use a simple and easy to understand interface format. So with this research, STMIK "AMIKBANDUNG" can upgrade the login system, with only one account can make it easier for students and staff to enter into one or more of the application services in STMIK "AMIKBANDUNG".
Perancangan Sistem Informasi Persediaan Bahan Baku Pada PT. Aneka Sarivita
Authors: Azizah Nur , Salsabila Fakhirah , Rahayu Lutfy 
Published: February 2022

The process of monitoring the inventory of raw materials in a company is very important. Because to find out the supply of raw materials that are still available, and so that there is no inhibition in the production process. But in fact, PT. Aneka Sarivita in recording raw material data still uses paper and is inputted using Microsoft Excel so that there is often a mismatch of the amount of raw material data with the amount in the warehouse. This system was built using PHP (Hypertext Preprocessor) as a programming language, MySQL as a database, Unified Modeling Language (UML) as a design method and SWOT (Strengths, Weaknesses, Opportunities, Threats) as an analysis method. The conclusion of this research is that a raw material inventory information system website is needed which aims to make the data search process accurate and the raw material inventory stock report can be controlled according to the raw material inventory in the warehouse.
Keywords—Inventory; Raw materials; SWOT

Proses monitoring persediaan bahan baku pada suatu perusahaan sangat penting. Karena untuk mengetahui persediaan bahan baku yang masih tersedia, serta supaya tidak terjadi penghambatan pada proses produksi. Namun pada kenyataanya, PT. Aneka Sarivita dalam pencatatan data bahan baku masih menggunakan kertas dan di input menggunakan Microsoft Excel sehingga sering terjadi ketidaksesuaian jumlah data bahan baku dengan jumlah yang berada di gudang. Sistem ini dibuat menggunakan PHP (Hypertext Preprocessor) sebagai bahasa pemrograman, MySQL sebagai database, Unified Modelling Language (UML) sebagai metode perancangan dan SWOT (Strengths, Weaknesses, Opportunities, Threats) sebagai metode analisa. Kesimpulan dari riset ini dibutuhkan sebuah website sistem informasi persediaan bahan baku yang bertujuan agar proses pencarian data menjadi akurat dan laporan stok persediaan bahan baku dapat terkontrol sesuai dengan persediaan bahan baku di gudang.
Kata Kunci—Persediaan; Bahan baku; SWOT
Perspectivas del Big data
Authors: Arcos Coba Jesús Alberto , Alvarado Barrera Lissette Fernanda , Muñoz Sánchez Kléver Paul 
Published: February 2022

En la actualidad, la humanidad está sumergida en un mundo de constantes cambios y evoluciones, presentada por la globalización y los grandes volúmenes de datos que se generan producto de los medios tecnológicos llámense internet, móviles, redes sociales, entre otros, como consecuencia han aparecido las tecnologías del Big Data, a fin de convertir esos datos en información útil para la sociedad y las organizaciones. Siendo el objetivo de la presente investigación indagar y conocer las perspectivas del Big Data, a través de las posiciones de los diferentes autores, para esto se usa una metodología de tipo documental, basada en el diseño bibliográfico. Esta revisión bibliográfica permitió concluir que a pesar de las barreras que se puedan presentar para la adquisición de las nuevas tecnologías, es más valiosa la información que se está generando y que puede ser depurada con las tecnologías del Big Data, siendo los profesionales más idóneos para manipular y gestionar esas tecnologías y sus herramientas, los ingenieros del área de informática o afines, por lo que deben mantenerse actualizados, así como la incorporación de dichas tecnologías en los currículos educativos de los centros universitario, garantizando profesionales de alta gama tan necesarios en la actualidad.
INFLUENCIAS DE ESTILOS ARQUITECTÓNICOS EN EL CENTRO HISTÓRICO DE CUENCA
Authors: Roura-Burbano Alexandra , Ochoa-Arias Paúl 
Published: February 2022

En el presente artículo se describe la influencia que ha recibido la arquitectura cuencana desde los diferentes estilos foráneos como: el Neoclásico Francés, el Art Nouveau, el Art Déco, el Racionalismo y otros, los mismos que se evidencian con notoriedad en algunas de las edificaciones del centro histórico de la ciudad.
Palabras Clave: Centro histórico Cuenca, arquitectura, patrimonio edificado, Neoclásico Francés, Art Nouveau, Art Déco.
AbstractThe present article describes the influence that Cuenca’s architecture has received from different foreign styles such as: French neoclassical, Art Nouveau, Art Deco, Rationalism, and others, which are strongly evident in some of the buildings in the Historic Center of the city.
Keywords: Historic Centre of Cuenca, architecture, building heritage, French neoclassical, Art Nouveau, Art Deco.
Pengaruh Ukuran Perusahaan, Leverage, dan Likuiditas terhadap Kualitas Laba dengan Profitabilitas sebagai Variabel Moderating
Authors: Azizah Vita Nurul , Asrori Asrori 
Published: February 2022

This research intends to find out the influence of firm size, leverage, and liquidity on earnings quality with profitability as a moderating variable. The property and real estate companies listed on Indonesia Stock Exchange for the period 2017 to 2020 is used as the population in this recearch. This study used a purposive sampling technique with 77 units of analysis obtained. The analytical technique used in this research is Ordinary Least Square (OLS) using the SPSS 25 application. The study shows that firm size have no influence on earnings quality and leverage have no influence on earnings quality, while liquidity has a significant positive influence on earnings quality. Profitability can strengthen the influence of company size on earnings quality. On the other hand, profitability can weaken the influence of leverage on earnings quality but, profitability can not strengthen the influence of liquidity on earnings quality. The conclusions of this research that liquidity has a significant positive influence on earnings quality. Profitability can strengthen the influence of firm size on earnings quality and profitability can weaken the influence of leverage on earnings quality. Suggestions for a new research are expected to add different independent variables which have influence on earnings quality
Analisis Pengaruh Suku Bunga, Harga Minyak Dunia, Harga Emas Dunia Terhadap Indeks Harga Saham Gabungan Dengan Inflasi Sebagai Variabel Moderating Di Indonesia
Authors: Mahendra A. , Amalia Mekar Meilisa , Leon Hengky 
Published: February 2022

This research is intended to know the influence of interest rate, world oil price, and world gold price on joint stock price index with inflation as a moderating variables in Indonesia. Population in this research is Indonesia and 20 of them were selected to be the samples for this research through purposive sampling technique. Estimates conducted by the multiple regression analysis. The data that were used in this study were secondary data, consisted of Interest Rate, World Oil Price, and World Gold Price to Joint Stock Price Index for the year 2000-2019. The results of this research, that Based on the partial test (t test), the Interest Rate variable has no significant effect while the World Oil Price and World Gold Price have a significant effect on the variables of the Joint Stock Price Index in Indonesia, the simultan test (F test), Interest Rate, World Oil Price and World Gold Price have a significant effect on the variables of the Joint Stock Price Index. The inflation are unable to moderate the relationship between interest rate, world oil price and world gold price on the joint stock price index.