bluuebunny/crossref_metadata_2025_split huggingface dataset:
The antifungal effects of the essential oils of Artemisia argyi and Acorus tatarinowii on Panax notoginseng root rot disease
Authors: Ling Cui-Qiong , Liao Hong-Xin , Nie Hong-Yan , Wen Jin-Rui , Xu Fu-Rong , Dong Xian 
Published: August 2022

Abstract
Essential oils (EOs) have a potent antifungal effect. Traditional Chinese medicines Artemisia argyi and Acorus tatarinowii have significant research value. Gas chromatography–mass spectrometry (GC–MS) was used to examine the chemical components of EOs from two therapeutic products. Panax notoginseng root rot pathogenic fungi were employed as target strains. The effect of EOs on pathogenic fungi was confirmed using the Oxford cup method and the chessboard method. The findings revealed that the two EOs as well as their principal chemical components exhibited potent inhibitory effects on pathogenic P. notoginseng. The combination of A. argyi, A. tatarinowii and hymexazol improved the inhibition of Fusarium oxysporum and Fusarium solani. This finding demonstrates that EO has strong antifungal properties and has the potential to be widely manufactured and used in agriculture. Thus, it is hypothesized that understanding the antifungal activity of plant EOs, such as those from A. argyi and A. tatarinowii, will aid in the resolution of agricultural cultivation problems, such as crop diseases caused by P. notoginseng, and lay the groundwork for the future development of green pesticides.
Synergistic effect of oxaliplatin and nanocurcumin in dendrosomal carrier to inhibits ovarian cancer cells invasion and metastasis through the long non-coding RNA MEG3
Authors: Hosseini Elahe Seyed , Zarei Marziyeh Alizadeh , Kashani Narjes Riahi , Kashani Hamed Haddad , Nikzad Hossein 
Published: August 2022

Abstract
Background: Ovarian cancer (OC) is a common female cancer with a high mortality rate. Maternally Expressed Gene 3 (MEG3) is a long non-coding RNA (lncRNA) located on chromosome 14q32.3 and act as an anti-tumor factor in various cancers. In this study we aimed to determine the role of siRNA–mediated MEG3 knockdown under dendrosomal nanocurcumin (DNC) and Oxaliplatin (OXA) treatment on ovarian cancer cell lines, also the expression levels of cancer-associated gene of Bcl-2, BAX, MMP-2 and MMP-9.Methods: We performed the MTT assay, flow cytometry for cell cycle analysis and Annexin V-FLUOS approach to evaluate the apoptosis, transwell migration and invasion assay in ovarian cancer cell lines. The expression analysis of lncRNA MEG3 and Bcl-2, BAX, MMP-2 and MMP-9 genes was also done using real-time PCR. Results: As result, we found MEG3 expression was significantly increased in two cell lines while it was in a time-dependent manner with OXA (24h and 48h) (P <0.01) and DNC (24h and 48h) (P <0.001) in OVCAR3 cell line. Also, siRNA-meditated MEG3 could significantly suppress many aspects of DNC and OXA anticancer effects in ovarian cancer cell lines. Real time analysis data demonstrated the increased expression of MMP-2 only in DNC (P <0.01) and combination treatment (P <0.001) and increased MMP-9 expression level only in OXA treatment after MEG3 downregulation (P <0.01).Conclusion: The findings of the current study illustrate MEG3 knockdown potentially can affect anti-cancer effects of DNC treatment in migration and invasion of ovarian cancer cell lines by change the expression levels of metastasis-associated genes MMP-2 and MMP-9. Then, it seems DNC and OXA combination treatment act as novel and efficient therapy in ovarian cancer, also MEG3 as a potential biomarker and therapeutic target for drug –resistance ovarian cells.
Comparison of Functional and Oncological Outcome of Conformal Sphincter Preservation Operation, Low Anterior Resection and Abdominoperineal Resection in Very Low Rectal Cancer; A Retrospective Comparative Cohort Study with Propensity Score Matching
Authors: Sun Ge , Lou Zheng , Zheng Kuo , Chen Yuntao , Zhang Hang , Wen Rongbo , Gao Xianhua , Meng Ronggui , Gong Haifeng , Bai Chenguang , Furnée Edgar J.B. , Zhang Wei 
Published: August 2022

Abstract
Purpose: Conformal sphincter preservation operation (CSPO) procedure is a sphincter preservation procedure for preserving the anal canal function for very low rectal cancers. This study investigated the functional and oncological outcome of conformal sphincter preservation operation by comparing with low anterior resection (LAR) and abdominoperineal resection (APR).
Methods: This is a retrospective comparative study. Patients who received conformal sphincter preservation operation (n=52), low anterior resection (n=54) or abdominoperineal resection (n=69) were included between 2011 and 2016 in a tertiary referral hospital. Propensity score matching was applied to adjust the baseline characteristics which may influence the choice of the surgical procedure.
Results: Twenty-one pairs of conformal sphincter preservation operation vs. low anterior resection and 29 pairs of conformal sphincter preservation operation vs. abdominoperineal resection were selected. The first group had a higher tumor location than the second group. Compared with the low anterior resection group, the conformal sphincter preservation operation group had shorter distal resection margins, however, no significant differences were identified in daily stool frequency, Wexner incontinence score, local recurrence, distant metastasis, overall survival, and disease-free survival between both groups. Compared with the abdominoperineal resection group, the conformal sphincter preservation operation group had shorter operative times and shorter postoperative hospital stay. No significant differences were identified in local recurrence, distant metastasis, overall survival, and disease-free survival.
Conclusion: Conformal sphincter preservation operation is oncologically safe compared to APR and LAR, and has similar functional findings to LAR. Studies comparing CSPO with intersphincteric resection should be performed.
Does matching degree matter for proximal femoral intramedullary nail on reoperation rate in intertrochanteric fractures?
Authors: Wang Fei , Zou Ji-Long , Shang Jian 
Published: August 2022

Abstract
IntroductionPrevious articles reported on the tip-apex distance, lag screw placement, fracture pattern, reduction quality, osteoporosis and other factors associated with second surgery. The current study focused on investigating the association of the matching degree between proximal femoral intramedullary nail and femoral medullary cavity on reoperation rate.Patients and methodsA retrospective cohort study was conducted. It included patients with intertrochanteric fracture who were treated with proximal femoral anti-rotatory intramedullary nail (PFNA) between January 2016 and April 2021. The gap between the intramedullary nail and the femoral medullary cavity was equal to the difference in diameter between the two. According to the gap size, all patients were divided into three groups, as follows: high-matching group: gap ≤ 2 mm; middle-matching group: 2 < gap < 4 mm; and low-matching group: gap ≥ 4 mm. The mean gap was measured through standard images. The primary observational index was whether the reoperation was needed, and secondary observational indexes included operative time, length of hospital stay. Patient characteristics were recorded, as follows: age, sex, follow-up time, fracture pattern, reduction grade and length of intramedullary nail.ResultsA total of 203 eligible patients were recorded, including 78 males (38.4%) and 125 females (61.6%). They had a mean age of 77.8 ± 9.9 years old and an average follow-up time of 58.1 ± 24.0 weeks. Twenty-seven patients (13.3%) needed a second operation. Coxa varus combined with screw cutting was the most common reason for reoperation (11 cases). Unstable fracture pattern with poor reduction grade tended to contribute to reoperation, whose odds ratio (OR) was 6.61 (95% confidence interval [CI], 1.98–22.09; p = 0.002). The three groups had 11 cases (13.7%), 12 cases (13.8%) and 4 cases (11.1%) of reoperation respectively and logistic regression showed no significant association was noted between matching degree of intramedullary nail and reoperation rate.ConclusionsThe matching degree between proximal femoral intramedullary nail and femoral medullary cavity did not seem to be an important factor for reoperation, which offered more options of intramedullary nail size intraoperatively and reduced implants stock from inventory.
Climatological changes in rain distributions at different rain-rates under Qinghai-Tibet Plateau warming during 1981-2060
Authors: Ayantobo Olusola Olaitan , Wei Jiahua , Wang Guangqian 
Published: August 2022

Abstract
Climatological changes in rainfall affect the Tibetan Plateau’s eco-hydrological processes and water resource regimes. To better understand these changes, we examined how rain amount distribution (RAD) and rain frequency distribution (RFD) has changed as well as future change under Tibetan Plateau warming. Daily rain accumulation from two observed datasets (Climate Prediction Center and Climate Forecast System Reanlysis) and CMIP6 models for SSP126, SSP245, and SSP585 are used to estimate RAD and RFD at each grid point. To capture the full range of rainfall from light to heavy, we used logarithmically distributed rain-rate bins, whose coordinates enable mathematical operations. This means that each rain-rate bin is a percentage wider in log coordinates than the previous one, with the same bin center. Results showed that RAD magnitudes varied from 0.74 to 0.93 mm/day at moderate rain-rates, with the broadest and narrowest curves occurring in 2011-2020 and 1991-2000, respectively. These distributions changed strongly from moderate to higher rain-rates at 2.8 mm/day/K. Further, RFD magnitudes ranged from 13.03% (1991-2000) to 13.51% (2011-2020), with a negative response at light rain-rates (-10.33%/K) and positive response at moderate rain-rates (10 %/K). Under future warming, RAD magnitudes were around 0.42 mm/day for the SSPs at moderate rain-rates, which shifted to higher rain-rates, implying that the RAD curve will become larger with more rain at higher rain-rates. Besides RAD whose response was around 2.85%/K under SSP126 at light rain-rate, most SSP126 responses were negative at light rain-rate but shifted positively and increased with SSP245 and SSP585 at higher rain-rates. This study will raise awareness of unexpected future events by showing how rain distribution changes with global warming.
Variability and magnitude of brain volume abnormalities in disruptive behavior disorders, antisocial personality disorder, and psychopathy - a meta-analysis
Authors: Tully John , Cross Ben , Gerrie Brooke , Griem Julia , Blackwood Nigel , Blair James , McCutcheon Robert 
Published: August 2022

Abstract
Individuals with Disruptive Behavior Disorders in youth and antisocial personality disorder and psychopathy as adults share some clinical characteristics, but also diverge in important ways. Existing meta-analyses of structural imaging studies suggest abnormalities within these disorders, however to date none have examined the role of variability. Hence, we performed a meta-analysis to examine both variability (log coefficient of variation ratio) and magnitude of brain volume differences between antisocial groups and healthy non-offenders (quantified using Hedges g). Twenty-seven studies met inclusion criteria. In antisocial individuals, there was significantly increased variability for total gray matter and overall decreases in mean volume for: total whole brain; intracranial volume; total gray matter; and amygdala, compared with healthy non-offenders. This suggests a key role for structural variability in clinical divergence within these disorders. Further studies should seek to specify how this neurobiological variability maps to clinical variability and whether this holds potential value as a biomarker to guide prognosis or treatment selection.
Safety and efficacy of single insertion accelerated MR-image guided brachytherapy following chemo-radiation in locally advanced cervix cancer: Modifying our EMBRACE during the COVID pandemic
Authors: Stevens Mark J , Ko Florence , Martland Judith , Brown Ryan , Bell Linda , Atyeo John , Yim Jackie 
Published: August 2022

Abstract
Background: Utero-vaginal brachytherapy (BT) is an irreplaceable care component in treating locally advanced cervix cancer (LACC). Magnetic Resonance Imaging (MRI)-image guided adaptive BT (IGABT) using the GYN-GEC-ESTRO EMBRACE regimen is the international care standard. Usually following chemo-radiation therapy (CRT), IGABT has high proven utility in LACC but requires significant health system resources. Timely access was disrupted by the COVID-19 pandemic, challenging us to re-design our established IGABT care pathway. Methods: From April 2020 consecutive patients with LACC were enrolled after CRT in a single arm exploratory non-inferiority study of a modified IGABT (mIGABT) protocol. Comparable to EMBRACE, our 3-fraction mIGABT delivered an iso-effective BT dose (39.3Gy: EQD2: α/β10Gy concept) over a 24-hour period during a single overnight hospitalisation. Results : Fourteen LACC patients received mIGABT from April 2020 to March 2022. Median age was 62.5 years (37-82 yrs.). LACC histology was primary squamous (9/14) or adeno-carcinoma (5/14). International Federation of Gynaecology and Obstetrics (FIGO) 2018 stages ranged from IB1/2 (N=3), IIA1/IIB (5), IIIB (2), IIIC1/2 (4) with mean ± standard deviation (SD) gross tumour volume (GTV) of 37.7cc ± 71.6cc. All patients achieved complete cancer response with CRT and IGABT. Two women developed systemic metastatic disease and one died at 12-months; 13 patients were alive without cancer at 15.5 ± 7.2 months follow-up. Actuarial 2-year overall survival was 93%.Prescribed dose covered at least 90% (D90) of the entire cervix and any residual cancer at time of BT (HRCTV_D90: high-risk clinical target volume) with 3-fractions of 8.5Gy delivered over 24-hours (22.8 ± 1.7 hrs). Overall treatment time including CRT was 38 days. The mIGABT schedule was well tolerated and met recommended (EQD2: α/β10Gy) target dose coverage 87.5 ± 3.7Gy, and organ-at-risk median: interquartile range D2cc constraints (EQD2: α/β3Gy) for bladder (65.9Gy: 58.4-72.5Gy), rectum (59.1Gy: 55.7-61.8Gy), and sigmoid colon (54.6Gy: 50.3-58.9Gy). ICRU recto-vaginal point dose was significantly higher (75.7Gy) in our only case of severe (G4) toxicity.Conclusions: This study demonstrated the utility of mIGABT and VMAT CRT in a small cohort with LACC. Loco-regional control was achieved in all cases. Single insertion IGABT was logistically efficient, cost-saving, and patient-centric during the COVID-19 pandemic.
Use of a cognitive behavioral therapy-based mobile application for non-patients with irritable bowel syndrome: preliminary evidence of effectiveness
Authors: Kobayashi Kana , So Yugan , Yamada Tatsuto , Fujii Yasushi 
Published: August 2022

Abstract
Non-patients with irritable bowel syndrome (IBS) experience severe pain associated with IBS symptoms but may have never consulted a doctor for the same. Cognitive behavioral therapy (CBT) is an effective treatment for relieving bowel pain and improving quality of life. However, it is usually employed only for severe cases in clinical trials. Thus, we aimed to develop and evaluate the effectiveness of a CBT-based application as a potential solution to the lack of accessible treatments for non-patients with IBS. The participants comprised non-patients with IBS, recruited online and randomly assigned to either the treatment (n = 5) or waitlist control (n = 6) condition. The application, used for two months with the therapist’s guidance, comprised three modules: psychoeducation, cognitive restructuring, and exposure. The following outcome measures were assessed at six time points: Gastrointestinal Symptom Rating Scale (GSRS), Irritable Bowel Syndrome-Quality of Life Questionnaire (IBS-QOL-J), Pain Catastrophizing Scale (PCS-J), Cognitive Scale for Functional Bowel Disorders (CS-FBD), Visceral Sensitivity Index (VSI), and Irritable Bowel Syndrome Behavioral Responses Questionnaire (IBS-BRQ). The waitlist control group used the application after the treatment group had completed the assessment. Group differences were evaluated using mixed-factors analysis of variance. The interaction of intervention condition × time was significant for the CS-FBD, VSI, and IBS-BRQ. However, no statistically significant between-group differences were observed for the GSRS, IBS-QOL-J, and PCS-J scores at different time points. While the application improved symptom-specific cognition and behavior and gastrointestinal-specific anxiety, it was not effective in improving IBS symptoms and quality of life.
Knowledge Attitude and Practice about Hepatitis C Virus and Associated Factors among Waste Handlers at Public Hospitals of Sidama Region, Ethiopia: Facility Based Cross Sectional Study
Authors: Betela Birhanu , Belayneh Mehretu 
Published: August 2022

Abstract
Background
Hepatitis C (HCV) is worldwide community health problem that gives rise to liver cancer. Even though prevalence of HCV is higher and waste handlers being at high risk for HCV, there is scarcity of information on knowledge, attitude and practice (KAP) concerning HCV among waste handlers.
Methods
Quantitative cross-sectional study from Oct 2021 to 30 July 2022 in different public Hospitals of Sidama Region aimed to evaluate KAP of HCV among randomly selected waste handlers was undertaken amongst 282 respondents. KAP regarding HCV were assessed using standardized structured questionnaire. Descriptive summary measures were done. Multivariate logistic regression was accompanied with 95% confidence interval and P-value < 0.05 was confirmed statistically significant. To assess the association between the KAP, Spearman’s rho correlation were used.
Results
Mean scores for KAP were 22.24 ± 8.15, 46.75 ± 10 and 4.19 ± 1.72 respectively. Educational level (OR = 2.427; 95% CI = [1.116 − 37.89], P = 0.042), monthly income (OR = 1.001; 95% CI = [1.000–10.002], P = 0.029), use of media (OR = 2.461; 95% CI = [2.688–8.799], P = 0.006), marital status (OR = 22.961; 95% CI = [1.203–38.157], P = 0.037) and residence (OR = 6.332; 95% CI = [1.703–23.544], P = 0.006) contributed significantly to the prediction of knowledge. Spearman rank correlation revealed significant positive correlations between knowledge-attitude (r = 0.57, P < 0.037), knowledge-practice (r = 0.265, P = 0.00) and attitude-practice (r = 0.72, P = 0.02).
Conclusions
Although the study highlighted optimal KAP with regards to several aspects of HCV, educational campaigns should emphasize the necessity of continued education about HCV in order to more improve attitudes, knowledge and practices of waste handlers regarding HCV.
Sustained Response on Sequential Anti-fgfr Therapy in Metastatic Gall Bladder Cancer - a Case Report and Literature Review
Authors: Sheth Hardik , Limaye Sewanti , Kumar Prashant , Shreenivas Aditya 
Published: August 2022

Abstract
Advanced gall bladder cancer (aGBC) is an aggressive disease with no consensus on treatment options beyond first line chemotherapy. We report a case of an elderly male with FGFR2 altered advanced adenocarcinoma of the gallbladder who failed two prior lines of chemotherapy but had sustained response and stable disease on sequential FGFR directed targeted therapy. This treatment was based on comprehensive genomic profiling by next-generation sequencing revealed FGR2 alteration. Sequential anti-FGFR tyrosine kinase inhibitors was initiated as a treatment of choice. The patient tolerated the sequential targeted therapy very well and had a sustained response and stable disease with 5 years of survival. Our study demonstrates that aGBC with FGFR alteration can be managed on anti-FGFR therapy for prolonged periods of time, with improved survival. The study revealed a FGFR-directed therapeutic as a viable treatment option in these patients.
The value of preoperative systemic inflammatory response index (SIRI) combined with albumin-bilirubin grading (ALBI) in predicting early recurrence following curative resection of single hepatocellular carcinoma
Authors: Fu Yubin , Feng Zhengkai , Xue Jiahao , Ge Penglei , Li Lin , Wu Yang 
Published: August 2022

Abstract
Background
This study was conducted to explore the risk factors for early recurrence of single hepatocellular carcinoma (HCC) following curative resection, and to evaluate the predictive value of systemic inflammatory response index (SIRI) combined with the albumin - bilirubin index (ALBI) for early recurrence of HCC following curative resection.
Methods
We retrospectively analyzed the clinical data of 233 patients with pathologically confirmed HCC who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2015 to January 2018. The optimal cut-off values of alpha-fetoprotein, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), SIRI, and ALBI were determined by receiver operating characteristic curve (ROC), and the predictive efficiency of each index was compared by area under curve (AUC). A Cox-proportional hazard regression model was used to analyze factors affecting early recurrence. Kaplan-Meier analysis was used to estimate the 2-year recurrence-free survival (RFS) rate of different factors.
Results
The AUC of SIRI for predicting early recurrence was 0.644, which was better than that of NLR, MLR, PLR, and SII. SIRI > 0.96, ALBI >-2.7, tumor diameter > 5 cm, and microvascular invasion (MVI) were risk factors for early recurrence after radical resection of HCC. The AUC of SIRI combined with ALBI was 0.759, which was better than that of single SIRI and ALBI. Combined with the above four risk factors, a new prognostic index was constructed, and the AUC for predicting early recurrence was 0.801.
Conclusion
SIRI, ALBI, MVI, and tumor diameter could be considered reliable predictors of early recurrence following curative resection of single HCC. Preoperative SIRI combined with ALBI possesses an important reference value in predicting early recurrence following radical resection of HCC. It is helpful for clinicians in identifying high-risk patients with early recurrence, actively carry out postoperative adjuvant treatment, and improving the prognosis of patients.
Breaking Bud Dormancy in Tea Crabapple [Malus hupehensis (Pamp.) Rehd.] with Cytokinins1
Authors: Broome Olivia C. , Zimmerman Richard H. 
Published: August 2022

Abstract
A technique is described for forcing the buds of tea crabapple using cytokinins. Of the cytokinins tested, 6-benzylamino purine (BA) produced the best results at 2,000 ppm, 6-(benzylamino)-9-(2-tetrahydropyranyl)-9H-purine (PBA) was nearly as effective, and N6-[Δ2-isopentenyl]-adenosine (IPA) and N6-[Δ2 isopentenyl]-adenine (2ip) were ineffective. Depending on the cytokinin used, inclusion of 0.5 or 1.0% surfactant was required to insure consistent results. No differences were found among 8 surfactants tested. Dimethylsulfoxide (DMSO) was an excellent solvent for the cytokinins and slightly enhanced their effect. The treatment effect was not translocated from the site of application. This method was consistent, faster than 10 weeks of cold treatment, less phytotoxic than cytokinins applied in a lanolin fraction, and permitted rapid spray application of small quantities of solution.