bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating community engagement with implementation science to advance the measurement of translational science
Authors: Gunn Christine M. , Sprague Martinez Linda S. , Battaglia Tracy A. , Lobb Rebecca , Chassler Deborah , Hakim Dema , Drainoni Mari-Lynn 
Published: August 2022

Abstract
This special communication provides an approach for applying implementation science frameworks to a Clinical and Translational Science Institutes (CTSIs) community engagement (CE) program that measures the use of implementation strategies and outcomes that promote the uptake of CE in research. Using an iterative multi-disciplinary group process, we executed a four-phased approach to developing an evaluation plan: 1) creating an evaluation model adapted from Proctor’s conceptual model of implementation research; 2) mapping implementation strategies to CTSI CE program interventions that support change in research practice; 3) identifying and operationalizing measures for each strategy; and 4) conducting an evaluation. Phase 2 employed 73 implementation strategies across 9 domains generated by the Expert Recommendations for Implementing Change project. The nine domains were used to classify each CE program implementation strategy. In Phase 3, the group used the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework to define measures for each individual strategy. Phase 4 demonstrates the application of this framework and measures Year 1 outcomes for the strategy providing interactive assistance, which we implemented using a centralized consultation model. This approach can support the CTSA program in operationalizing CE program measurement to demonstrate which activities and strategies may lead to benefits derived by the program, institution, and community.
Culture and group-functional punishment behaviour
Authors: Espín Antonio M. , Brañas-Garza Pablo , Gamella Juan F. , Herrmann Benedikt , Martín Jesús 
Published: August 2022

AbstractHumans often ‘altruistically’ punish non-cooperators in one-shot interactions among genetically unrelated individuals. This poses an evolutionary puzzle because altruistic punishment enforces cooperation norms that benefit the whole group but is costly for the punisher. One key explanation is that punishment follows a social-benefits logic: it is eminently normative and group-functional (drawing on cultural group selection theories). In contrast, mismatch-based deterrence theory argues that punishment serves the individual-level function of deterring mistreatment of oneself and one's allies, hinging upon the evolved human coalitional psychology. We conducted multilateral-cooperation experiments with a sample of Spanish Romani people (GitanosorCalé) and the non-Gitanomajority. TheGitanosrepresent a unique case study because they rely heavily on close kin-based networks and display a strong ethnic identity. We find thatGitanonon-cooperators were not punished by co-ethnics in only-Gitano(ethnically) homogeneous groups but were harshly punished by otherGitanosand by non-Gitanosin ethnically mixed groups. Our findings suggest the existence of culture-specific motives for punishment:Gitanos, especially males, appear to use punishment to protect their ethnic identity, whereas non-Gitanosuse punishment to protect a norm of universal cooperation. Only theories that consider normative, group-functional forces underlying punishment behaviour can explain our data.
Distal systems in topological dynamics and ergodic theory
Authors: EDEKO NIKOLAI , KREIDLER HENRIK 
Published: August 2022

AbstractWe generalize a result of Lindenstrauss on the interplay between measurable and topological dynamics which shows that every separable ergodic measurably distal dynamical system has a minimal distal model. We show that such a model can, in fact, be chosen completely canonically. The construction is performed by going through the Furstenberg–Zimmer tower of a measurably distal system and showing that at each step there is a simple and canonical distal minimal model. This hinges on a new characterization of isometric extensions in topological dynamics.
Automated hand hygiene compliance system’s audible alert reminder increases healthcare worker hand hygiene compliance
Authors: Webster Kristen L. , Bishop Sarah M. , Scott LaShawn E. , Oppy Leah M. , Heishman Crystal R. , Stevenson Gina M. , Arnold Forest W. 
Published: August 2022

AbstractObjective:To evaluate the effectiveness of an automated hand hygiene compliance system (AHHCS) audible alert and vibration for increasing hand hygiene compliance.Design:A nonrandomized, before-and-after, quasi-experimental study of an AHHCS was implemented in several inpatient units. Over a 51-day period, the system’s real-time audible alert was turned on, off, and back on. Overall, hand hygiene compliance was compared between days with activated and deactivated alerts and vibration.Setting:This study was conducted at a level 1 trauma center, a regional academic health system with 1,564 beds.Participants:The AHHCS was implemented in 9 inpatient units: 3 adult medical-surgical step-down units, and 6 adult intensive care units. The AHHCS badges were assigned to patient care assistants, registered nurses, physical therapists, occupational therapists, speech therapists, respiratory therapists, and physicians.Intervention:In the 9 inpatient units, selected healthcare staff were issued wearable badges that detected entry into and exit from a patient room. The audible alert was turned on for 16 days, turned off for 17 days, and then turned back on for 18 days, for a total of 51 days.Results:Utilization of the AHHCS real-time audible alert reminder resulted in sustained HH compliance ≥90%. When the alert and vibration were deactivated, HH compliance dropped to an average of 74% (range, 62%–78%). Once the alert resumed, HH compliance returned to ≥90%.Conclusion:Utilization of an AHHCS with real-time reminder audible alerts may be an effective method to increase healthcare worker HH compliance to ≥90%. Users of AHHCSs should consider the use of real-time reminders to improve HH compliance.
Wright about Wight: A dialect glossary of the Isle of Wight based on EDD Online
Authors: Markus Manfred 
Published: August 2022

AbstractDescribing specific dialect areas in terms of their lexis is an attractive idea now that the latest version of the English Dialect Dictionary Online (EDD Online 3.0, 2019) allows for quick and easy lexical retrievals of English dialect words of the Late Modern English period. This paper uses the Isle of Wight (I.W.) as a test case for putting such an idea into practice. The 137 words uniquely attributed in the EDD to I.W. are analyzed and interpreted in relation to the 1500-odd words used on I.W. alongside other areas of the UK. The paper informs the reader of the available query modes and discusses their pros and cons, quantifying and mapping the different numbers of isolated words in use on I.W. versus those unique to other English counties. The larger number of words that the island shared with the counties of the “mainland” will likewise be considered, thus allowing for first steps towards a “dialectometrical” analysis. The findings are related to the historical background of I.W., particularly in the 18th and 19th centuries.
Dispersals from the West Tethys as the source of the Indo-West Pacific diversity hotspot in comatulid crinoids
Authors: Saulsbury James G. , Baumiller Tomasz K. 
Published: August 2022

AbstractConspicuous centers of biodiversity are frequently attributed to local conditions that promote speciation or resistance to extinction, but recent diversification studies indicate this mode of explanation might not be very general, so it may be fruitful to revisit the role of dispersal in concentrating biodiversity. Here we consider the processes underlying the marine diversity hotspot in the Indo-West Pacific among comatulid crinoids, suspension-feeding echinoderms conspicuous on modern tropical reefs. We used ancestral-range reconstruction on a phylogeny of extant crinoids, assembled a new occurrence database of fossil comatulids and interrogated it with probabilistic preservational models, and developed a morphological character matrix to estimate the relationships among living and fossil comatulids. Ancestral-range reconstruction on a phylogeny of extant comatulids recovers an origin outside the Indo-Pacific and elevated dispersal into it. A new occurrence database records the comatulid clade spreading out gradually from origin in the Early Jurassic of the West Tethys. Comatulids do not appear in their modern hotspot until the Oligocene, and taphonomic analyses show these results cannot be explained solely as a result of inadequate sampling in Asia and Oceania. Finally, phylogenetic analyses demonstrate that deeply nested crown-group comatulids had originated before the clade became well established in the East Tethys, implying many independent dispersals into the modern hotspot. These consilient results suggest a biodiversity hotspot that owes its existence to dispersals out of the ancient West Tethys rather than to elevated in situ diversification.
High dietary Ca and microbial phytase reduce the expression of Ca transporters while enhancing claudins involved in paracellular Ca absorption in the porcine jejunum and colon
Authors: Hu Yixin , van Baal Jurgen , Hendriks Wouter H. , Resink Jan-Willem , Liesegang Annette , van Krimpen Marinus M. , Bikker Paul 
Published: August 2022

AbstractExpression levels of genes (RT-qPCR) related to Ca and P homeostasis (transporters and claudins (CLDN)) were determined in porcine jejunal and colonic mucosa. Forty growing pigs (BW 30·4 (sem 1·3) kg) received a low and high Ca content (2·0 and 9·6 g/kg, respectively) diet with or without microbial phytase (500 FTU/kg) for 21 d. Dietary Ca intake enhanced serum Ca and alkaline phosphatase concentration and reduced P, 1,25(OH)2D3, and parathyroid hormone concentration. Jejunal transient receptor potential vanilloid 5 (TRPV5) mRNA expression was decreased (32%) with phytase inclusion only, while colonic TRPV5 mRNA was reduced by dietary Ca (34%) and phytase (44%). Both jejunal and colonic TRPV6 mRNA expression was reduced (30%) with microbial phytase. Calbindin-D9k mRNA expression was lower in colonic but not jejunal mucosa with high dietary Ca (59%) and microbial phytase (37%). None of the mRNAs encoding the Na–P cotransporters (NaPi-IIc, PiT-1, PiT-2) were affected. Jejunal, but not colonic expression of the phosphate transporter XPR1, was slightly downregulated with dietary Ca. Dietary Ca downregulated colonic CLDN-4 (20%) and CLDN-10 (40%) expression while CLDN-7 was reduced by phytase inclusion in pigs fed low dietary Ca. Expression of colonic CLDN-12 tended to be increased by phytase. In jejunal mucosa, dietary Ca increased CLDN-2 expression (48%) and decreased CLDN-10 (49%) expression, while phytase slightly upregulated CLDN-12 expression. In conclusion, compared with a Ca-deficient phytase-free diet, high dietary Ca and phytase intake in pigs downregulate jejunal and colonic genes related to transcellular Ca absorption and upregulate Ca pore-forming claudins.
The Social Biography: Pitfalls and Temptations
Authors: Stutje Jan Willem 
Published: August 2022

AbstractThere were times – not so long ago – when it seemed that historical processes could be dissected as though human action did not matter. Those times have changed. Nowadays, scholarly biography is enjoying broad interest, also among social historians, as is shown in this issue of the IRSH, in which John D. French explains how biography can contribute to a better understanding of global labour history. This contribution addresses three issues. Firstly, the relationship between agency (subject) and structure, or the role of the personality in history and society; secondly, the question of charismatic leadership, and finally, the question of how to deal with issues of necessity and coincidence and with the selection of leadership.
Lactobacillus buchneri inoculation compared to chitosan and facultative heterofermentative lactic acid bacteria improves sugarcane silage conservation
Authors: Del Valle T. A. , Campana M. , Pereira N. R. , Osório J. A. C. , Garcia T. M. , Capucho E. , de Morais J. P. G. 
Published: August 2022

AbstractThe present study aimed to evaluate the effects of chitosan instead of microbial inoculants on fermentation profile, losses, chemical composition, in vitro degradation, and aerobic stability of sugarcane silage (SS). Forty experimental silos (PVC tubes with 28 cm i.d., 25 cm height) were used in a randomized block design to evaluate the following treatments: (I) Control (CON): SS with no additive; (II) LB: SS ensiled with 5.0 × 105 colony forming units (CFU) of Lactobacillus buchneri (NCIM 40788)/g as-fed; (III) LPPA: SS ensiled with 1.6 × 105 CFU of L. plantarum and 1.6 × 105 CFU of Pediococcus acidilactici/g as-fed; and (IV) Chitosan (CHI): SS ensiled with 6 g/kg dry matter (DM) of chitosan. Microbial inoculation of SS reduced (P ≤ 0.05) silage pH relative to CON and CHI treatment. The LPPA decreased ammonia-nitrogen and LB decreased (P ≤ 0.05) ethanol content and increased acetic acid content relative to other treatments. The LPPA-silos had higher (P ≤ 0.05) gas losses and lower (P ≤ 0.05) DM recovery than other treatment silos. Consequently, LPPA reduced (P ≤ 0.05) DM and non-fibre carbohydrates and increased (P ≤ 0.05) neutral detergent fibre (NDF) silage content compared to other treatments. Treatments did not affect (P ≥ 0.212) DM and NDF in vitro degradation and silage pH after aerobic exposure. However, LB reduced silage temperature after aerobic exposure. Thus, LB reduces alcoholic fermentation and improves SS aerobic stability. Inoculation of LPPA reduces DM recovery and negatively affects SS chemical composition. Although CHI positively affects SS conservation relative to CON, it shows higher gas losses and decreased SS temperature after aerobic exposure compared to LB.
Intercropping and cover crop effects on maize nitrogen requirement for optimal growth
Authors: Souza S. S. , Flôres J. A. , Coelho A. P. , Deienno J. M. , Lemos L. B. , Rolim G. S. 
Published: August 2022

AbstractIntercropping maize (Zea mays L.) with cover crops (Crotalaria spectabilis and Urochloa ruziziensis) is a sustainable cultivation strategy that can generate ecological benefits combined with grain yield (GY). However, cover crops may require nitrogen (N) fertilization management to be adjusted to obtain a high GY in intercropping systems. This study was carried out over 2 years in southeastern Brazil using randomized complete block design in a split-plot scheme. The plots were composed of three cropping systems: sole maize, maize + U. ruziziensis and maize + C. spectabilis. The subplots consisted of four N levels: 0, 70, 140 and 210 kg/ha. The GY of the maize + U. ruziziensis may be reduced by 13% compared to the sole maize. The GY of the sole maize increased up to 11.3 Mg/ha for 95 kg/ha of N in the first year and 6.7 Mg/ha for 169 kg/ha of N in the second year. The GY of the maize + U. ruziziensis intercropping system showed linear increments of 120 kg/ha for every 10 kg/ha of N applied. In the maize + C. spectabilis intercropping, GY increased up to 9.8 Mg/ha for 201 kg/ha of N in the first year, without any variation during the second year. The land equivalent ratio (LER) of intercropping was increased by more than 35% compared to that of sole maize, and N fertilization increased the LER of the sole maize and maize + U. ruziziensis intercropping. Maize intercropping had higher LER values with greater demand for nitrogen to obtain similar yields compared to sole maize cropping.
Long-term storage of microalgae: determination of optimum cryopreservation conditions
Authors: Deniz Irem , Demirel Zeliha , Imamoglu Esra , Conk-Dalay Meltem 
Published: August 2022

AbstractMaintenance of eukaryotic microalgae strains for the long term is generally carried out using serial subculture techniques which require labour, time and cost. Cryopreservation techniques provide long-term storage of up to years for numerous microorganism strains and cell cultures. Ssu930ijn vbvbhnn8;l,n is related to a successfully designed mass and heat transfer balance throughout the cell. In this study, optimization of the cryopreservation process was carried out for two commercially used microalgal strains. The parameters to be optimized were DMSO percentage (0–25%), incubation time (1–15 min) and cryopreservation term (7–180 days) using a central composite design (CCD). Long-term storage up to 123.17 and 111.44 days corresponding to high cell viabilities was achieved for Chlorella vulgaris and Neochloris texensis, respectively. Generated models were found to be in good agreement with experimental results. The study also revealed holistic results for storage of microalgal strains in a stable state for industrial applications.
Between- and within-person effects of stress on emotional eating in women: a longitudinal study over 49 days
Authors: Fowler Natasha , Mikhail Megan E. , Neale Michael , Keel Pamela K. , Katzman Debra K. , Sisk Cheryl L. , Burt S. Alexandra , Klump Kelly L. 
Published: August 2022

AbstractBackgroundStress is associated with binge eating and emotional eating (EE) cross-sectionally. However, few studies have examined stress longitudinally, limiting understanding of how within-person fluctuations in stress influence EE over time and whether stress is a risk factor or consequence of EE. Additionally, little is known regarding how the biological stress response relates to EE.MethodsWe used an intensive, longitudinal design to examine between-person and within-person effects of major life stress, daily stress, and cortisol on EE in a population-based sample of women (N = 477; ages 15–30; M = 21.8; s.d. = 3.0) from the Michigan State University Twin Registry. Participants reported past year major life stress, then provided daily ratings of EE and stress for 49 consecutive days. Hair cortisol concentration (HCC) was collected as a longitudinal biological stress measure.ResultsWomen reported greater EE when they experienced greater mean stress across days (between-person effects) or greater stress relative to their own average on a given day (within-person effects). Daily stress was more strongly associated with EE than major life stress. However, the impact of daily stress on EE was amplified in women with greater past year major life stress. Finally, participants with lower HCC had increased EE.ConclusionsFindings confirm longitudinal associations between stress and EE in women, and highlight the importance of within-person shifts in stress in EE risk. Results also highlight HCC as a novel biological stress measure that is significantly associated with EE and may overcome limitations of prior physiological stress response indicators.
Passive Remote Monitoring and Aging in Place: A Scoping Review
Authors: Read Emily , Woolsey Cora , Donelle Lorie , Weeks Lori , Chinho Norma 
Published: August 2022

AbstractPassive remote monitoring is a relatively new technology that may support older adults to age in place. However, current knowledge about the effectiveness of this technology in extending older adults’ independence is lacking. Therefore, we conducted a scoping review of studies examining passive remote monitoring to systematically synthesize evidence about the technology’s effectiveness as an intervention. Our initial search of Embase, CINAHL, PubMed, and Scopus databases identified 486 unique articles. Of these, 14 articles met our inclusion criteria. Results show that passive remote monitoring technologies are being used in innovative and diverse ways to support older adults aging in place and their caregivers. More high-quality research on this topic is needed.
The New Recipe for a General Principle of Law: Premise Theory to “Fill in the Gaps”
Authors: OCHI Megumi 
Published: August 2022

AbstractThis article proposes a new theory, “premise theory”, to account for recent international criminal courts’ practice on finding general principles of law. After analysing the traditional theory of transposition from national to international legal settings, and the modification/choice model, this article demonstrates that the focus should be shifted from arbitrariness to the determinants of results of recognizing general principles of law. Premise theory explains a mechanism that judges modify a common legal principle or choose the most appropriate national legal principle to apply to the issue at hand to reflect the premises of the legal field, the court, and, sometimes, even the individual case. This article concludes with a proposal for utilizing premise theory as an explanatory tool and as a guide for legal reasoning to increase judicial transparency and predictability. Lastly, it advocates for the application of premise theory to other areas of international law.
Triennium Linguae Latinae: a case study of introducing Latin to the Key Stage 3 timetable in a comprehensive school
Authors: McMillan Ian David 
Published: August 2022

AbstractA personal reflection on the experience of introducing Latin to the curriculum. School S. (non-selective, secondary) introduced Latin as a timetabled subject at Key Stage 3 between 2016 and 2019. This is a case study and personal reflection from the teacher who instigated and taught the course, comprising the extracurricular efforts which paved the way for the class, methodological considerations, an evaluation of the project, and the reasons why Latin was ultimately discontinued from the curriculum.
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients
Authors: Zhang Hongsheng , Shao Lin , Lin Zhihao , Long Quan-Xin , Yuan Huilong , Cai Lujian , Jiang Guangtong , Guo Xiaoyi , Yang Renzhi , Zhang Zepeng , Zhang Bingchang , Liu Fan , Li Zhiyong , Ma Qilin , Zhang Yun-Wu , Huang Ai-Long , Wang Zhanxiang , Zhao Yingjun , Xu Huaxi 
Published: August 2022

AbstractApolipoprotein E (APOE) plays a pivotal role in lipid including cholesterol metabolism. The APOE ε4 (APOE4) allele is a major genetic risk factor for Alzheimer’s and cardiovascular diseases. Although APOE has recently been associated with increased susceptibility to infections of several viruses, whether and how APOE and its isoforms affect SARS-CoV-2 infection remains unclear. Here, we show that serum concentrations of APOE correlate inversely with levels of cytokine/chemokine in 73 COVID-19 patients. Utilizing multiple protein interaction assays, we demonstrate that APOE3 and APOE4 interact with the SARS-CoV-2 receptor ACE2; and APOE/ACE2 interactions require zinc metallopeptidase domain of ACE2, a key docking site for SARS-CoV-2 Spike protein. In addition, immuno-imaging assays using confocal, super-resolution, and transmission electron microscopies reveal that both APOE3 and APOE4 reduce ACE2/Spike-mediated viral entry into cells. Interestingly, while having a comparable binding affinity to ACE2, APOE4 inhibits viral entry to a lesser extent compared to APOE3, which is likely due to APOE4’s more compact structure and smaller spatial obstacle to compete against Spike binding to ACE2. Furthermore, APOE ε4 carriers clinically correlate with increased SARS-CoV-2 infection and elevated serum inflammatory factors in 142 COVID-19 patients assessed. Our study suggests a regulatory mechanism underlying SARS-CoV-2 infection through APOE interactions with ACE2, which may explain in part increased COVID-19 infection and disease severity in APOE ε4 carriers.