bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parathyroidectomy Versus Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Hemodialysis Patients
Authors: Alvarado Luis , Sharma Nishtha , Lerma Roxann , Dwivedi Alok , Ahmad Adeel , Hechanova Aimee , Payan‐Schober Fernanda , Nwosu Azikiwe , Alkhalili Eyas 
Published: January 2022

AbstractBackgroundSecondary hyperparathyroidism in patients with end stage renal disease on dialysis is associated with bone pain and fractures in addition to cardiovascular morbidity. Cinacalcet is the most commonly used drug to treat such patients, but it has never been compared to surgery. The goal of this study is to compare the long‐term outcomes and survival between cinacalcet and parathyroidectomy in the treatment of secondary hyperparathyroidism in hemodialysis patients.MethodsAdult patients on hemodialysis who were treated with cinacalcet or parathyroidectomy in the United States Renal Data System were included. Patients treated with surgery (n = 2023) were compared using 1:1 propensity score matching ratio to a cohort of patients treated with cinacalcet. A Cox regression analysis was conducted to compare the overall mortality.ResultsThe propensity score matching successfully created two groups with similar demographics. Patients in the surgery group had a higher mean peak PTH level prior to therapy (2066.8 vs 1425.4, P < 0.001). No difference was observed in the development of new‐onset coronary artery disease (7.7% vs 7.9%, P = 0.8) or cerebrovascular disease (7% vs 6.7%, P = 0.8). Surgical patients had a higher rate of pathologic fractures (27.8% vs 24.9%, P = 0.04). Survival analysis showed that patients undergoing surgery had a better 5‐year survival (65.6% vs 57.8%) and were less likely to die within the study period (HR 0.77, 95% CI 0.7–0.85, P < 0.0001).ConclusionsPatients on dialysis undergoing parathyroidectomy for the treatment of secondary hyperparathyroidism have a better overall survival than those treated with cinacalcet.
Acute effects of ketamine on the pregenual anterior cingulate: linking spontaneous activation, functional connectivity, and glutamate metabolism
Authors: Gärtner Matti , Weigand Anne , Scheidegger Milan , Lehmann Mick , Wyss Patrik O. , Wunder Andreas , Henning Anke , Grimm Simone 
Published: January 2022

AbstractKetamine exerts its rapid antidepressant effects via modulation of the glutamatergic system. While numerous imaging studies have investigated the effects of ketamine on a functional macroscopic brain level, it remains unclear how altered glutamate metabolism and changes in brain function are linked. To shed light on this topic we here conducted a multimodal imaging study in healthy volunteers (N = 23) using resting state fMRI and proton (1H) magnetic resonance spectroscopy (MRS) to investigate linkage between metabolic and functional brain changes induced by ketamine. Subjects were investigated before and during an intravenous ketamine infusion. The MRS voxel was placed in the pregenual anterior cingulate cortex (pgACC), as this region has been repeatedly shown to be involved in ketamine’s effects. Our results showed functional connectivity changes from the pgACC to the right frontal pole and anterior mid cingulate cortex (aMCC). Absolute glutamate and glutamine concentrations in the pgACC did not differ significantly from baseline. However, we found that stronger pgACC activation during ketamine was linked to lower glutamine concentration in this region. Furthermore, reduced functional connectivity between pgACC and aMCC was related to increased pgACC activation and reduced glutamine. Our results thereby demonstrate how multimodal investigations in a single brain region could help to advance our understanding of the association between metabolic and functional changes.
Primary systemic therapy for patients with brain metastases from lung cancer ineligible for targeted agents
Authors: Nieder Carsten , Aanes Siv G. , Haukland Ellinor 
Published: January 2022

Abstract
Purpose
The purpose of this study was to evaluate overall survival after systemic therapy, largely chemotherapy, in patients with small cell or non-small cell lung cancer and brain metastases. After completion of systemic therapy, some patients received planned brain irradiation, while others were followed.

Methods
Retrospective cohort study.

Results
Thirty-eight patients were included (28 small cell, 20 followed with imaging). Six of these 20 patients (30%) received delayed radiotherapy during follow-up. Planned radiotherapy (n = 18, intention-to-treat) was associated with longer survival from diagnosis of brain metastases, median 10.8 versus 6.1 months, p = 0.025. Delayed radiotherapy still resulted in numerically better survival than no radiotherapy at all (median 8.8 versus 5.3 months, not significant). If calculated from the start of delayed radiotherapy, median survival was only 2.7 months. In a multivariable analysis, both Karnofsky performance status ≥ 70 (p = 0.03) and planned radiotherapy (p = 0.05) were associated with better survival.

Conclusion
In patients ineligible for targeted agents, planned radiotherapy in a modern treatment setting was associated with longer survival compared to no radiotherapy. Timing and type of radiotherapy in such patients should be evaluated in prospective trials to identify patients who might not need planned radiotherapy.
Midterm osteolysis-induced aseptic failure of the M6-C™ cervical total disc replacement secondary to polyethylene wear debris
Authors: Scott-Young Matthew , Rathbone Evelyne , Grierson Lauren 
Published: January 2022

Abstract
Background
According to published meta-analyses, cervical total disc replacement (CTDR) seems to be superior to anterior cervical decompression and fusion (ACDF) in most clinical parameters. Despite short-term clinical success of CTDR, there are concerns regarding long-term durability of these prostheses.

Methods
This prospective study involved 382 patients who received standalone CTDR or a hybrid procedure (ACDF/CTDR). A retrospective comparison between different CTDR devices was conducted regarding patient-reported outcome measures (PROMs), failure scenarios, and revision surgeries. The M6-C™ Artificial Cervical Disc (Orthofix, Lewisville, Texas) cohort was compared to the other CTDR devices clinically. Etiological reasons for revision, and the surgical technique of the revision was investigated.

Results
Fifty-three patients received M6-C CTDR. Eighteen patients (34%) were revised at an average of 67 months postoperatively for wear-induced osteolysis. There were three additional cases of pending revision. The PROMs of the two groups were similar, indicating that the failure mode (wear-induced osteolysis) is often asymptomatic. The demographics of the two groups were also similar, with more women undergoing revision surgery than men. There were three one-level CTDR, four two-level hybrids, seven three-level hybrids, and three four-level hybrids revised anteriorly. Sixteen patients underwent removal of the prosthesis and were treated according to the extent of osteolysis. There were four vertebrectomies, six revisions to ACDF, and six revisions to another CTDR. One patient underwent supplemental fixation using a posterior approach. The other CTDR cohort had an incidence of 3.3% at the equivalent time, and none of these were due to osteolysis or wear-related events.

Conclusions
There is a concerning midterm failure rate related to ultra-high-molecular-weight-polyethylene wear-induced osteolysis in the M6-C. Patients implanted with the M6-C prosthesis should be contacted, informed, and clinically and radiologically assessed.
Effects of Habitat-Specific Primary Production on Fish Size, Biomass, and Production in Northern Oligotrophic Lakes
Authors: Norman Sven , Nilsson Karin A. , Klaus Marcus , Seekell David , Karlsson Jan , Byström Pär 
Published: January 2022

AbstractEcological theory predicts that the relative distribution of primary production across habitats influence fish size structure and biomass production. In this study, we assessed individual, population, and community-level consequences for brown trout (Salmo trutta) and Arctic char (Salvelinus alpinus) of variation in estimated habitat specific (benthic and pelagic) and total whole lake (GPPwhole) gross primary production in 27 northern oligotrophic lakes. We found that higher contribution of benthic primary production to GPPwholewas associated with higher community biomass and larger maximum and mean sizes of fish. At the population level, species-specific responses differed. Increased benthic primary production (GPPBenthic) correlated to higher population biomass of brown trout regardless of being alone or in sympatry, while Arctic char responded positively to pelagic primary production (GPPPelagic) in sympatric populations. In sympatric lakes, the maximum size of both species was positively related to both GPPBenthicand the benthic contribution to GPPWhole. In allopatric lakes, brown trout mean and maximum size and Arctic char mean size were positively related to the benthic proportion of GPPWhole. Our results highlight the importance of light-controlled benthic primary production for fish biomass production in oligotrophic northern lakes. Our results further suggest that consequences of ontogenetic asymmetry and niche shifts may cause the distribution of primary production across habitats to be more important than the total ecosystem primary production for fish size, population biomass, and production. Awareness of the relationships between light availability and asymmetric resource production favoring large fish and fish production may allow for cost-efficient and more informed management actions in northern oligotrophic lakes.
Are polypropylene mesh implants associated with systemic autoimmune inflammatory syndromes? A systematic review
Authors: Kowalik C. R. , Zwolsman S. E. , Malekzadeh A. , Roumen R. M. H. , Zwaans W. A. R. , Roovers J. W. P. R. 
Published: January 2022

Abstract
Purpose
The surgical implantation of polypropylene (PP) meshes has been linked to the occurrence of systemic autoimmune disorders. We performed a systematic review to determine whether PP implants for inguinal, ventral hernia or pelvic floor surgery are associated with the development of systemic autoimmune syndromes.

Methods
We searched Embase, Medline, Web of Science, Scopus, Cochrane library, clinicaltrialsregister.eu, clinicaltrails.gov and WHO-ICTR platform. Last search was performed on November 24th 2021. All types of studies reporting systemic inflammatory/autoimmune response in patients having a PP implant for either pelvic floor surgery, ventral or inguinal hernia repair were included. Animal studies, case reports and articles without full text were excluded. We intended to perform a meta-analysis. The quality of evidence was assessed with the Newcastle–Ottawa Scale. This study was registered at Prospero (CRD42020220705).

Results
Of 2137 records identified, 4 were eligible. Two retrospective matched cohort studies focused on mesh surgery for vaginal prolapse or inguinal hernia compared to hysterectomy and colonoscopy, respectively. One cohort study compared the incidence of systemic conditions in women having urinary incontinence surgery with and without mesh. These reports had a low risk of bias. A meta-analysis showed no association when comparing systemic disease between mesh and control groups. Calculated risk ratio was 0.9 (95% CI 0.82–0.98). The fourth study was a case series with a high risk of bias, with a sample of 714 patients with systemic disease, 40 of whom had PP mesh implanted.

Conclusion
There is no evidence to suggest a causal relationship between being implanted with a PP mesh and the occurrence of autoimmune disorders.
A Fractal Simulation Method for Simulating the Resource Abundance of Oil and Gas and Its Application
Authors: Guo Qiulin , Ren Hongjia , Wu Xiaozhi , Liu Zhuangxiaoxue , Wei Yanzhao , Liu Jifeng , Liu Haoyun , Yu Jingdu , Zhang Qian 
Published: January 2022

AbstractIn this study, a fractal simulation method for simulating resource abundance is proposed based on the evaluation results of the exploration risk and prediction technology for the spatial distribution of oil and gas resources at home and abroad. In addition, a key technical workflow for simulating resource abundance was developed. Furthermore, the model for predicting resource abundance has been modified, and the objective functions for conditional simulation have been improved. A series of prediction technologies for predicting the spatial distribution of oil and gas resources have been developed, and the difficulties in visualizing the exploration risks and predicting the spatial distribution of oil and gas resources have been solved. Prediction technologies have been applied to the Jurassic Sangonghe Formation in the hinterland of the Junggar Basin, and good results have been obtained. The results indicated that within the known area, taking the known abundance as the constraint condition, the coincidence rate of the simulated quantities of the original model and the improved model with the actual reserves reached 99.98% after the conditional simulation, indicating that the conditional simulation was effective. In addition, with the improved model, the predicted remaining resources are 0.7899$$\times 10^{8}$$

×

10
8

t, which is 65% of the discovered reserves, and the original model predicts that the remaining resources are 3.5033$$\,\times \,10^{8}$$

×

10
8

t, which is 2.89 times greater than the discovered reserves. Compared with the area in the middle stage of exploration, the results of the improved model are more consistent, and the results of the original model are obviously larger, indicating that the improved model has a good predictive effect for the unknown area. Finally, according to the risk probability and remaining resource distribution, the favorable areas for exploration were optimized as follows: the neighborhood of the triangular area formed by Well Lunan1, Well Shimo1, and Well Shi008, the area near Well Mo11, the area east of Well Mo5, the area west of Well Pen7, the area southwest of Well Shidong1, and the surroundings, as well as the area north of Well Fang2. The application results show that these prediction technologies are effective and can provide important reference and decision-making for resource evaluation and target optimization.
Bioactive nano-selenium antagonizes cobalt nanoparticle-mediated oxidative stress via the Keap1-Nrf2-ARE signaling pathway
Authors: Wang Siqi , Wang Chen , Zhang Weinan , Fan Wentao , Liu Fan , Liu Yake 
Published: January 2022

AbstractAt present, no effective treatment exists for the clinical toxicity of cobalt nanoparticles (CoNPs, 30 nm) after metal-on-metal (MOM) artificial joint replacement. As such, a better understanding of the CoNPs-toxicity mechanism is necessary and urgent for the development of effective and safe detoxification drugs. Our purpose was to explore the role of bioactive nano-selenium (BNS, > 97%) in antagonizing the toxicity of CoNPs and its mechanism through the Keap1-Nrf2-ARE signaling pathway. To examine BNS detoxification, we exposed HUVEC cells to CoNPs and BNS for 24 h, before measuring cell activity, reactive oxygen species (ROS), the GSH level, inflammatory factors, and KNA signaling pathway-related transcript and protein expression. CoNPs stimulate intracellular inflammation and ROS production to bring about significant downregulation of cellular activity and the GSH level. Conversely, BNS reduces ROS generation and suppresses inflammatory factors within cells to reduce CoNPs-mediated cytotoxicity, possibly via the KNA signaling pathway. Based on our results, BNS antagonizes CoNPs toxic effects by suppressing ROS production through the KNA pathway. Our research provides new insight into the clinical treatment of CoNPs toxicity and explores the potential of BNS in detoxification therapy. Trial registration: no human participant.
Observation of magnetic droplets in magnetic tunnel junctions
Authors: Shi Kewen , Cai Wenlong , Jiang Sheng , Zhu Daoqian , Cao Kaihua , Guo Zongxia , Wei Jiaqi , Du Ao , Li Zhi , Huang Yan , Yin Jialiang , Åkerman Johan , Zhao Weisheng 
Published: January 2022

AbstractMagnetic droplets, a class of highly nonlinear magnetodynamic solitons, can be nucleated and stabilized in nanocontact spin-torque nano-oscillators. Here we experimentally demonstrate magnetic droplets in magnetic tunnel junctions (MTJs). The droplet nucleation is accompanied by power enhancement compared with its ferromagnetic resonance modes. The nucleation and stabilization of droplets are ascribed to the double-CoFeB free-layer structure in the all-perpendicular MTJ, which provides a low Zhang-Li torque and a high pinning field. Our results enable better electrical sensitivity in fundamental studies of droplets and show that the droplets can be utilized in MTJ-based applications and materials science.
Mechanical Characteristics and Structure of Highly Deformed Zinc
Authors: Ostachowski Paweł , Paliborek Anna , Bochniak Włodzimierz , Łagoda Marek 
Published: January 2022

AbstractThe paper contains a set of experimental data on the influence of the KOBO extrusion (extrusion with simultaneous cyclic torsion) on mechanical properties of pure zinc and proves that they can be controlled in order to achieve the desired final values, while tensile characteristics may either show monotonic course or contain the Lüders-type effect. It has been found that the mechanical properties of the KOBO extruded zinc are not linked to the grain size, thus proving the hypothesis about the dominating role of over-equilibrial concentration of point defects (including their clusters).
Waste Pharmaceutical Blister Packages as a Source of Secondary Aluminum
Authors: Shukla Sugam , Halli Petteri , Khalid Muhammad Kamran , Lundström Mari 
Published: January 2022

AbstractWaste pharmaceutical blister packages (WPBs) are a source of solid waste, which are composed of plastics and aluminum, therefore acting as a potential source for secondary aluminum. The structure of WPBs makes the recycling of aluminum notably more complex than typical aluminum recycling. Currently, WBPs are disposed of as municipal solid waste; thus, aluminum is lost from the circulation during incineration. In this work, three types of WPBs were studied, each with two plastic layers and a metallic layer. Delamination of WPBs to separate aluminum and plastic(s) was investigated by using a solution of organic solvents. The effects of temperature (30–50°C), acetone to isopropanol ratio (0–100 vol.%) and different types of WPBs on delamination behavior were investigated. The results suggest that aluminum separation and recovery from WPBs is 100% at optimum conditions. Moreover, an overall indicative flowsheet for recycling and post-processing of segregated aluminum from the plastic is also suggested.
Anthocyanin-Colored Microencapsulation Effects on Survival Rate of Lactobacillus rhamnosus GG, Color Stability, and Sensory Parameters in Strawberry Nectar Model
Authors: Morsy Mohamed K. , Morsy Osama M. , Abdelmonem Mohamed A. , Elsabagh Rasha 
Published: January 2022

AbstractProbiotic microencapsulation is a promising way to produce functional food, while their stability and sensory acceptability still a challenge. This study aims to enhance the functional properties of strawberry (Fragaria × ananassa, cultivar Camarosa) nectar and sensory acceptance using novel anthocyanin-colored microencapsulation of Lactobacillus rhamnosus. Four formulations (F1–F4) of coated materials (alginate, whey protein, and pullulan) integrated with anthocyanin pigment were used for encapsulation. The physical properties of microencapsulated probiotics (size, color, efficiency, stability, and survival rate) and quality parameters of nectar (pH, anthocyanin, and sensory acceptability) during 4 weeks of storage at 4 and 25 °C were evaluated. All formulations exhibited high encapsulation efficiency (> 89%), medium bead size (406–504 μm), and proper color (red color). The microencapsulated cells were stable in simulated gastrointestinal and processing conditions (up 7 log10 CFU mL−1) compared to free cells. F4 (alginate 2% + anthocyanin 0.1% + whey protein 2% + pullulan 2% + cocoa butter 1% + L. rhamnosus GG) showed the greatest viability in nectar during storage (6.72 log10 CFU mL−1/4 °C/4 weeks), while a significant decrease in pH (< 2) and anthocyanin (< 60 mg 100 g−1) was observed in nectar-containing free cells. The sensory scores with a difference-preference test as exploratory and preliminary responses revealed that colored probiotic microcapsules enhanced the sensory characters (up to 4 weeks) and commercially accepted (> 80% agreed) of strawberry nectar. Results demonstrated that anthocyanin-colored alginate-whey protein-pullulan matrix had the potential to enhance probiotic viability in functional nectar without negative impact.
Generative design of 3D printed hands-free door handles for reduction of contagion risk in public buildings
Authors: De Crescenzio F. , Fantini M. , Asllani E. 
Published: January 2022

AbstractDuring the emergency caused by COVID 19 evidence has been provided about the risk of easily getting the virus by touching contaminated surfaces and then by touching eyes, mouth, or nose with infected hands. In view of the restarting of daily activities in presence, it is paramount to put in place any strategy that, in addition to social distancing, is capable to positively impact on the safety levels in public buildings by reducing such risk. The main aim of this paper is to conceive a design methodology, based on a digital, flawless, and sustainable procedure, for producing human-building interfacing solutions that allow anybody to interact in a safer and more comfortable way. Such solutions are focused on the adaptation of existing buildings features and are thought to be an alternative to sensor based touchless technology when this is not applicable due to economic or time constraints. The process is based on the integration of digital technologies such as 3D Scanning, Generative Design and Additive Manufacturing and is optimised to be intuitive and to be adaptive, hence, to be replicable on different kinds of surfaces. The design concept is finalised to generate automatically different products that meet geometry fitting requirements and therefore adapt to the specific geometries of existing handles. A specific case on Hands Free Door Handles is presented and the results of manufacturing and preliminary validation process are provided and discussed.