bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor-Faktor Yang Mempengaruhi Status Gizi Balita Di Desa Penggalaman Kecamatan Martapura Barat
Authors: Anwar Rosihan 
Published: April 2022

Based on Riskesdas 2018, the prevalence of malnutrition nationally fluctuated because in 2013 the prevalence of malnutrition was 19.6% and decreased in 2018 to 17.7%. According to the 2017 Nutritional Status Assessment based on the BB/U index in Indonesia, children under five suffer from malnutrition by 3.5%, malnutrition 11.3%, and in South Kalimantan children under five were malnourished 3.6% and undernourished was 12.9%.
This type of research is analytic observational with a cross-sectional research design. The population is all families who have children under five.
KK SD/equivalent education is 28%, SMP/equivalent is not in school as much as 44%, while the mother's last education is SD/equivalent 45%, SMP/equivalent. KK are farmers 50%, traders 8%, civil servants/private employees 22%. Mothers work as housewives 92%, civil servants 2%. Poor nutritional status category 12%, good 84%. The level of energy consumption for toddlers in the category of more than 6%, good is 0%. The level of protein consumption for toddlers with more categories is 82%, either 10%. Infectious diseases 46% and those that are not 54%. Availability of food in good category 56%, sufficient 38% and less 6%. Mother's parenting pattern with good category 68%, moderate 30% and less 2%.
There is no significant relationship between intake of energy consumption, infectious diseases, food availability and parenting patterns with the nutritional status of children under five according to BB/TB.
Keywords: nutritional status, income, occupation, energy and protein consumption, infection, food availability
ANALYSIS AND VISUALIZATION OF MARKET SEGEMENTATION IN BANKING SECTOR USING KMEANS MACHINE LEARNING ALGORITHM
Authors: Durojaye D. I. , Obunadike Georgina 
Published: April 2022

Segmentation is a way of assigning each dataset to a segment called cluster. It is widely applied in different area of human endeavor such as banking sector, health sector, retail, media etc. Many organizations are faced with problems of ineffective customer care services and intelligent management decisions because of inability to effectively analyze customer data that will give insight to the nature of customers to help in effective customer services and intelligent management decision. Kmeans algorithm is the widely used algorithm for market segmentation, normally the k value of Kmeans algorithm are randomly picked. Picking the optimal k value is usually a challenge in application of Kmeans algorithm and this usually affects the performance of Kmeans algorithm. This work applies elbow method to obtain the optimal k value that was applied to analyze dataset from banking sector (in this case United Bank of Africa) for better insight, business management and marketing strategy. The customer cluster created was evaluated using visual plots and cluster centers. The optimal k value of six (6) was obtained using the elbow function. The dataset was thus segmented based on the optimal k value of 6 obtained. The clustering results obtained showed high intra cluster similarity (data within a cluster are similar) and low inter cluster similarity (data from different clusters are dissimilar). The result also showed that customers in cluster 3 and 4 has similar marketing needs and can be served together
Peran Pelatihan dan Keterikatan Kerja Untuk Meningkatkan Kinerja Karyawan Pada Industri Telekomunikasi
Authors: Ruhiyat Imam , Meria Lista , Julianingsih Dwi 
Published: April 2022

Penelitian ini dilakukan dengan tujuan untuk mengetahui peran pelatihan, keterikatan kerja terhadap kinerja pegawai pada pegawai pada Industri Penyediaan Jasa Telekomunikasi yang berdomisili di wilayah Jabodetabek. Variabel bebasnya adalah pelatihan, keterikatan kerja, sedangkan variabel terikatnya adalah kinerja pegawai. Populasi dalam penelitian ini adalah karyawan yang berdomisili di wilayah Jabodetabek yang bekerja di perusahaan jasa telekomunikasi. Jumlah sampel yang terdapat dalam penelitian ini adalah 200 responden. Teknik pengambilan sampel yang terdapat dalam penelitian ini menggunakan metode non probability sampling dengan teknik purposive sampling, pengujian instrumen data menggunakan uji validitas dan uji reliabilitas. Metode yang digunakan dalam penelitian ini adalah Structural Equation Modeling (SEM). Berdasarkan penelitian ini ditemukan bahwa pelatihan berpengaruh positif dan signifikan terhadap kinerja karyawan. Selanjutnya pelatihan berpengaruh positif dan signifikan terhadap work engagement. Kemudian work engagement berpengaruh positif dan signifikan terhadap kinerja karyawan.
Kata kunci : Pelatihan, Keterlibatan Kerja, Kinerja Karyawan.
Kinerja Desentralisasi dan Sistem Akuntansi Manajemen Terhadap Kinerja Manajer Pada Bisnis Perhotelan di Kota Palembang
Authors: Fitriasuri Fitriasuri , Arsyad Sholahuddin 
Published: April 2022

Abstract
The purpose of this study in general is to determine the role of decentralization and management accounting systems on the performance of hotel business managers in the Palembang city area. The independent variables used are decentralization and management accounting systems, while the dependent variable is the manager's performance. The sample in this study were 38 respondents who were managers from various levels. The 38 respondents came from 10 hotels in Palembang. Respondents were selected using purposive random sampling method. Data were collected using a questionnaire with 35 questions and analyzed using Linear Regression. The results of the analysis show R Square 48.6% and a significance level of 0.001. The results of the study indicate that decentralization and management accounting systems simultaneously affect the performance of managers in the hospitality sector in the city of Palembang. For the partial test, the significance level of the decentralization variable is 0.068 and the regression coefficient is 0.374, which means that decentralization partially has no effect on the manager's performance, while the significance level of the management accounting system is 0.004 and the regression coefficient is 0.447, which means that the management accounting system partially has a positive effect on the performance of hotel managers. .
Keywords: decentralization, management accounting system, manager performance

Abstrak
Tujuan penelitian ini secara umum adalah untuk mengetahui Kinerja desentralisasi dan sistem akuntansi manajemen terhadap kinerja manajer bisnis perhotelan yang ada di wilayah kota Palembang. Variabel independen yang digunakan adalah desentralisasi dan sistem akuntansi manajemen, sedangkan variabel dependen adalah kinerja manajer. Sampel yang diteliti dalam penelitian ini sebanyak 38 responden manajer dari berbagai tingkatan dan berasal dari 10 hotel yang ada di kota Palembang yang dipilih menggunakan metode purposive random sampling. Data dikumpulkan menggunakan kuisioner dengan 35 butir pertanyaan. Data dianalisis menggunakan Regresi Linear. Hasil analisis menunjukkan nilai R2 sebesar 48,6% dan tingkat signifikan sebesar 0,001. Hasil penelitian menunjukkan bahwa desentralisasi dan sistem akuntansi manajemen secara bersama-sama memberikan pengaruh terhadap kinerja manajer di bidang perhotelan di kota Palembang. Untuk Uji parsial tingkat signifikansi variabel desentralisasi adalah 0,068 dan koefisien regresi 0,374 yang artinya desentralisasi secara parsial tidak berpengaruh terhadap kinerja manajer, sedangkan tingkat signifikansi sistem akuntansi manajemen adalah 0,004 dan koefisien regresi 0,447 yang artinya sistem akuntansi manajemen secara parsial berpengaruh positif terhadap kinerja manajer bidang perhotelan.
Kata Kunci: desentralisasi, sistem akuntansi manajemen, kinerja manajer
In Vitro Study of Endothelial Cell Morphology and Gene Expression in Response to Wall Shear Stress Induced by Arterial Stenosis
Authors: Mu Lizhong , Liu Xiaolong , Liu Mengmeng , Long Lili , Chi Qingzhuo , He Ying , Pan Yue , Ji Changjin , Gao Ge , Li Xiaona 
Published: April 2022

Objectives: We examined the correlation between changes in hemodynamic characteristics induced by arterial stenosis and vascular endothelial cell (EC) morphology and gene expression in straight silicone arteries.Materials and methods: Transparent silicone straight artery models with four degrees of stenosis (0, 30, 50, and 70%) were fabricated. Particle image velocimetry was performed to screen silicone vessel structures with good symmetry and to match the numerical simulations. After the inner surface of a symmetric model was populated with ECs, it was perfusion-cultured at a steady flow rate. A computational fluid dynamics (CFD) study was conducted under the same perfusion conditions as in the flow experiment. The high-WSS region was then identified by CFD simulation. EC morphology in the high-WSS regions was characterized by confocal microscopy. ECs were antibody-stained to analyze the expression of inflammatory factors, including matrix metalloproteinase (MMP)-9 and nuclear factor (NF)-κB, which were then correlated with the CFD simulations.Results: As the degree of vascular stenosis increases, more evident jet flow occurs, and the maximum WSS position moves away first and then back. ECs were irregularly shaped at vortex flow regions. The number of gaps between the cells in high-WSS regions increased. The MMP-9 and NF-κB expression did not differ between vessels with 30 and 0% stenosis. When arterial stenosis was 70%, the MMP-9 and NF-κB expression increased significantly, which correlated with the regions of substantially high WSS in the CFD simulations.Conclusion: Stenotic arteries induce hemodynamic stress variations, which contribute to differences in EC morphology and gene expression. A high degree of vascular stenosis can directly increase inflammatory factor expression.
In Vivo Corneal Biomechanical Properties in a Selected Chinese Population, Measured Using the Corneal Visualization Scheimpflug Technology
Authors: Li Yuxin , Tian Lei , Guo Li-Li, , Hao Yiran , Jie Ying 
Published: April 2022

Purpose: To evaluate the repeatability and reproducibility of recalculated dynamic corneal response (DCR) parameters and the biomechanical-compensated intraocular pressure (bIOP) derived from the Corneal Visualization Scheimpflug Technology (Corvis ST), as well as to study the variations of DCR parameters and their relationship with demographic, and ocular characteristics.Methods: A total of 544 healthy subjects were recruited in this study and a series of ophthalmological examinations were performed on their right eyes. Three repeated measurements were obtained at 3-min intervals for 291 of the participants to ensure repeatability. A sum of 100 participants was examined twice within 2-h intervals using two different Corvis ST in the reproducibility study. The repeatability and reproducibility of 37 parameters, including 36 DCR parameters and bIOP, were assessed by the coefficient of repeatability (CR), coefficient of variation (CV), intraclass correlation coefficient (ICC), and within-subject standard deviation (sw). Pearson’s correlation coefficients and stepwise multivariate linear regression models were performed to investigate whether the DCR parameters were related to demographic and ocular characteristics.Results: Of all the 37 parameters, 34 showed excellent (ICC ≥0.90) or good (ICC ≥0.75) repeatability while 27 of the 37 parameters showed excellent (ICC ≥0.90) or good (ICC ≥0.75) reproducibility. In particular, a CV of less than 20% was found for all DCR parameters and bIOP. A fraction of 14 out of 36 DCR parameters was selected for correlation analysis, based on measurement reliability and clinical relevance in referring to previous literature. Age was negatively associated with the Highest concavity delta arc length (HCdArcL) and peak distance (PD) but it positively correlated with the Whole Eye Movement Max Length (WEMML). Intraocular pressure (IOP) and central corneal thickness (CCT) were negatively associated with the deformation amplitude ratio (DARM) [1 mm], A1 Velocity (A1V), and PD, while positively related to the stiffness parameter at applanation 1 (SP-A1). The bIOP was negatively associated with A1V but positively associated with A2 Velocity (A2V). The anterior chamber volume (ACV) was negatively associated with the pachy slope (PS), WEMML, and SP-A1.Conclusion. The Corvis ST showed good precision for the repeatability and reproducibility of 36 DCR parameters and bIOP parameters in healthy eyes. The IOP, CCT, bIOP, Km, and ACV significantly influenced the DCR parameters of the eyes.
Characterization of Specific Signatures of the Oral Cavity, Sputum, and Ileum Microbiota in Patients With Crohn’s Disease
Authors: Xia Kai , Gao Renyuan , Wu Xiaocai , Sun Jing , Wan Jian , Wu Tianqi , Fichna Jakub , Yin Lu , Chen Chunqiu 
Published: April 2022

BackgroundCrohn’s disease (CD) is a chronic nonspecific inflammatory bowel disease (IBD) with an increasing incidence worldwide. The etiology of CD is still obscure, but microbial dysbiosis has been recognized as an essential factor contributing to CD. However, few studies have revealed the microbiome’s signatures and reciprocal correlations between multiple sites in patients with CD over different disease stages. This study investigated the specific microbial architectures of the oral cavity, sputum, and ileum in patients with CD in the active and remission stages.MethodsMicrobial samples from the oral cavity, sputum, and ileum were collected from patients with CD in the active and remission stages and healthy controls. The microbial composition was assessed by 16S ribosomal RNA (rRNA) gene sequencing. In addition, bioinformatics methods were used to demonstrate the microbial signatures, functional changes, and correlations between microbiota and clinical data in CD.ResultsCompared with healthy controls, a distinct microbiota dysbiosis in the oral cavity, sputum, and ileum of patients with CD was identified, characterized by alterations in microbiota biodiversity and composition. The oral cavity and sputum microbiota showed significantly lower microbial diversity in patients with CD than in healthy controls. In terms of microbiota composition, the microbiota changes in the oral cavity of patients with CD were similar to those in the sputum, while they were different from those in the ileum. In the oral cavity and sputum of patients with CD, a lower relative abundance of Firmicutes and Actinobacteria was observed compared to healthy controls, which was most prominent in the active stage. In contrast, an increased relative abundance of Fusobacteria, Porphyromonas, and Haemophilus was observed in patients with CD. The predicted metabolic pathways involved in the oral cavity, sputum, and ileum were similar, predominantly involving metabolism, environmental information processing, and genetic information processing.ConclusionThe results revealed the alterations of microbiota architecture in the oral cavity, sputum, and ileum of patients with CD, which varied across disease stages. Studying microbiota dysbiosis may bring new insights into the etiology of CD and lead to novel treatments.
Long-Term Risk of Death From Heart Disease Among Breast Cancer Patients
Authors: Agha Aya , Wang Xi , Wang Ming , Lehrer Eric J. , Horn Samantha R. , Rosenberg Jennifer C. , Trifiletti Daniel M. , Diaz Roberto , Louie Alexander V. , Zaorsky Nicholas G. 
Published: April 2022

BackgroundMost breast cancer patients die of non-cancer causes. The risk of death from heart disease, a leading cause of death, is unknown. The aim of this study is to characterize the long-term risk of fatal heart disease in breast cancer patients.MethodsThis retrospective study used the Surveillance, Epidemiology, and End Results (SEER) database. Standard mortality ratios (SMR) were calculated for breast cancer patients diagnosed from 1992 to 2014. Patients were stratified by receipt of radiotherapy and/or chemotherapy, disease laterality, and diagnosis era. Hazard ratios (HRs) and odds ratios (ORs) were calculated to compare the risk of death from heart disease among other breast cancer patients.ResultsThere were 1,059,048 patients diagnosed with breast cancer from 1992 to 2014, of which 47,872 (4.6%) died from heart disease. The SMR for death from heart disease at 10+ years for patients who received only radiotherapy was 2.92 (95% CI 2.81–3.04, p &lt; 0.001) and in patients who received only chemotherapy was 5.05 (95% CI 4.57–5.55, p &lt; 0.001). There was no statistically significant difference in SMR for death from heart disease for left-sided vs. right-sided disease. At 10+ years, heart disease made up 28% of deaths from non-primary cancer. HRs and ORs showed that the risk of death from heart disease was highest in patients older than 70 years of age and with longer follow-up.ConclusionThe risk of fatal heart disease was highest in older breast cancer patients with longer follow-up (i.e., &gt;5–10 years) and who received chemotherapy. These patients should be referred to cardio-oncology clinics to mitigate this risk.
Clinical Outcomes of Drug-Coated Balloon Treatment After Successful Revascularization of de novo Chronic Total Occlusions
Authors: Jun Eun Jung , Shin Eun-Seok , Teoh Eu-Vin , Bhak Youngjune , Yuan Song Lin , Chu Chong-Mow , Garg Scot , Liew Houng Bang 
Published: April 2022

BackgroundThe safety and efficacy of drug-coated balloon (DCB) treatment for de novo coronary chronic total occlusion (CTO) remain uncertain. The aim of this study was to evaluate the outcomes of DCB only treatment for de novo CTO.MethodsIn this retrospective study, 101 vessels with de novo CTO lesions dilated by balloon angioplasty with thrombolysis in myocardial infarction flow grade 3 were included. Among them, 93 vessels successfully treated with DCB only treatment were analyzed. The study endpoint was major adverse cardiac events (MACE) at 2 years, a composite of cardiac death, non-fatal myocardial infarction (MI), target vessel revascularization (TVR), and target vessel thrombosis. The secondary endpoint was late lumen loss (LLL) on follow-up coronary angiography.ResultsAll 84 patients were followed up clinically, and 67 vessels underwent scheduled coronary angiography after 6 months. There were no procedural complications, and three vessels required bailout-stenting. The median follow-up was 720 days (interquartile range [IQR]; 406–1,268 days). MACE occurred in 8.3% of the patients after 1 year, including cardiac death (1.2%), TVR (7.1%), and no non-fatal MI and target vessel thrombosis. Two years after treatment, MACE occurred in 16.7% of the patients, including cardiac death (2.4%), non-fatal MI (3.6%), TVR (13.1%), and no target vessel thrombosis. The mean LLL was 0.03 ± 0.53 mm. Binary restenosis occurred in 14.9% of the treated vessels, and 3.0% of the vessels had late re-occlusion on follow-up coronary angiography.ConclusionsIf the result of revascularization using balloon angioplasty is good, the clinical outcomes of DCB only treatment of de novo CTOs at the 2-year follow-up are encouraging, with a low rate of hard endpoints and acceptable MACE rates (Clinical Trial Registration Information; Impact of Drug-coated Balloon Treatment in de novo Coronary Lesion; NCT04619277).
Tanshinone IIA Has a Potential Therapeutic Effect on Kawasaki Disease and Suppresses Megakaryocytes in Rabbits With Immune Vasculitis
Authors: Chen Hui , Shu Huiying , Su Weiqing , Li Bo , Zhang Hua , Li Liang , Lin Chao , Yi Wenfang , Zhan Xiao-Yong , Chen Chun , Li Xiaojing , Yang Yanqi , Zhou Min , Yang Mo 
Published: April 2022

Background and ObjectiveIt is urgent to find out an alternative therapy for Kawasaki disease (KD) since around 20% patients are resistant to intravenous immunoglobulin (IVIG) or aspirin. Tanshinone IIA is the active component of the traditional Chinese medicine Danshen (Salvia miltiorrhiza), which has anti-inflammatory and anti-platelet properties; however, whether or not tanshinone IIA has a therapeutic effect on KD remains unclear. Therefore, the present study aimed to examine the effect of tanshinone IIA on KD patients and rabbits with immune vasculitis, and to identify the potential mechanisms with special emphasis on megakaryopoiesis and megakaryocytic apoptosis.MethodsKawasaki disease patients were recruited and prescribed with tanshinone IIA in the absence or presence of aspirin and IVIG, and the inflammatory responses and platelet functions were determined. Megakaryocytes (MKs) isolated from rabbits with immune vasculitis and human megakaryocytic CHRF-288-11 cells were treated with tanshinone IIA to examine the colony forming unit (CFU) and apoptosis, respectively. Microarray assay was conducted to identify potential targets of tanshinone IIA-induced apoptosis.ResultsTanshinone IIA reduced the serum levels of C-reactive protein (CRP), interleukin (IL)-1β, IL-6, and P-selectin in KD patients; such inhibitory effect was more significant compared to aspirin and IVIG. It also dose-dependently lowered the levels of tumor necrosis factor (TNF)-α and IL-8 in peripheral blood mononuclear cells isolated from KD patients. In rabbits with immune vasculitis, tanshinone IIA significantly reduced the serum levels of proinflammatory cytokines and platelet functions. In addition, tanshinone IIA significantly decreased the number of bone marrow MKs and inhibited the Colony Forming Unit-Megakaryocyte (CFU-MK) formation. In human megakaryocytic CHRF-288-11 cells, tanshinone IIA induced caspase-dependent apoptosis, probably through up-regulating TNF receptor superfamily member 9 (TNFRSF9) and the receptor (TNFRSF)-interacting serine/threonine-protein kinase 1 (RIPK1), which may contribute to its anti-platelet and anti-inflammatory properties.ConclusionTanshinone IIA exerts better anti-inflammatory and anti-platelet effects in treating KD patients than aspirin and IVIG. It attenuates immune vasculitis likely by inhibiting IL-mediated megakaryopoiesis and inducing TNFRSF9/RIPK1/caspase-dependent megakaryocytic apoptosis. The findings therefore suggest that tanshinone IIA may be a promising alternative therapy for the treatment of KD.