bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors predicting successful discontinuation of acute kidney replacement therapy: A retrospective cohort study
Authors: Ohara Cristine Naomi , Suarez Maria Irma , Kitawara Koody Hassemi , Zamoner Welder , Balbi André Luis , Ponce Daniela 
Published: September 2022

AbstractBackgroundTreatment for severe acute kidney injury (AKI) typically involves the use of acute kidney replacement therapy (AKRT) to prevent or reverse complications.MethodologyWe aimed to determine the prevalence of successful discontinuation of AKRT and its predictive factors. A retrospective cohort study was performed with 316 patients hospitalized at a public Brazilian university hospital between January 2011 and June 2020.ResultsSuccess and hospital discharge were achieved for most patients (85% and 74%, respectively). Multivariable logistic regression analysis showed that C‐reactive protein (CRP), urine output, and need mechanical ventilation at the time of interruption were variable associated with discontinuation success (OR 0.969, CI 0.918–0.998, p = 0.031; OR 1.008, CI 1.001–1.012, p = 0.041 and OR 0.919, CI 0.901–0.991, p = 0.030; respectively), while the absence of comorbidities such as chronic kidney disease (OR 0.234, CI 0.08–0.683, p = 0.008), cardiovascular disease (OR 0.353, CI 0.134–0.929, p = 0.035) and hypertension (OR 0.278, CI 0.003–0.882, p = 0.009), as well as pH values at the time of AKRT indication (OR 1.273, CI 1.003–1.882, p = 0.041), mechanical ventilation at the time of interruption (OR 0.19, CI 0.19–0.954, p = 0.038) and successful discontinuation (OR 8.657, CI 3.135–23.906, p < 0.001) were identified as variables associated with hospital discharge.ConclusionThese results show that clinical conditions such as comorbidities, urine output, and mechanical ventilation, and laboratory variables such as pH and CRP are factors associated with hospital discharge and AKRT discontinuation success, requiring larger studies for confirmation.
Comparison of hemodynamics in biological surgical aortic valve replacement and transcatheter aortic valve implantation: An in‐silico study
Authors: Franke Benedikt , Schlief Adriano , Walczak Lars , Sündermann Simon , Unbehaun Axel , Kempfert Jörg , Solowjowa Natalia , Kühne Titus , Goubergrits Leonid 
Published: September 2022

AbstractObjectivesIn aortic valve replacement (AVR), the treatment strategy as well as the model and size of the implanted prosthesis have a major impact on the postoperative hemodynamics and thus on the clinical outcome. Preinterventional prediction of the hemodynamics could support the treatment decision. Therefore, we performed paired virtual treatment with transcatheter AVR (TAVI) and biological surgical AVR (SAVR) and compared hemodynamic outcomes using numerical simulations.Methods10 patients with severe aortic stenosis (AS) undergoing TAVI were virtually treated with both biological SAVR and TAVI to compare post‐interventional hemodynamics using numerical simulations of peak‐systolic flow. Virtual treatment procedure was done using an in‐house developed tool based on position‐based dynamics methodology, which was applied to the patient's anatomy including LVOT, aortic root and aorta. Geometries were automatically segmented from dynamic CT‐scans and patient‐specific flow rates were calculated by volumetric analysis of the left ventricle. Hemodynamics were assessed using the STAR CCM+ software by solving the RANS equations.ResultsVirtual treatment with TAVI resulted in realistic hemodynamics comparable to echocardiographic measurements (median difference in transvalvular pressure gradient [TPG]: −0.33 mm Hg). Virtual TAVI and SAVR showed similar hemodynamic functions with a mean TPG with standard deviation of 8.45 ± 4.60 mm Hg in TAVI and 6.66 ± 3.79 mm Hg in SAVR (p = 0.03) while max. Wall shear stress being 12.6 ± 4.59 vs. 10.2 ± 4.42 Pa (p = 0.001).ConclusionsUsing the presented method for virtual treatment of AS, we were able to reliably predict post‐interventional hemodynamics. TAVI and SAVR show similar hemodynamics in a pairwise comparison.
Clinical characteristics and long‐term outcomes in patients with peripartum cardiomyopathy (PPCM) receiving left ventricular assist devices (LVAD)
Authors: Berliner Dominik , Li Tong , Mariani Silvia , Hamdan Righab , Hanke Jasmin , König Tobias , Pfeffer Tobias Jonathan , Abou‐Moulig Valeska , Dogan Günes , Hilfiker‐Kleiner Denise , Haverich Axel , Bauersachs Johann , Schmitto Jan D. 
Published: September 2022

AbstractBackgroundPeripartum cardiomyopathy (PPCM) is a rare cause of heart failure (HF), presenting with left ventricular (LV) systolic dysfunction either at the end of pregnancy or in the months following delivery. In rare cases, PPCM leads to severe impairment of LV function, refractory cardiogenic shock or advanced HF. LV assist devices (LVAD) have been shown to be a feasible treatment option in advanced HF. However, little is known about long‐term outcomes and prognosis of PPCM patients undergoing LVAD implantation.MethodsA retrospective analysis of data from PPCM patients undergoing LVAD implantation in two tertiary centers with respect to long‐term outcomes was performed.ResultsTwelve patients of median age 30 (18–39) years were included. Eight patients were experiencing cardiogenic shock (INTERMACS 1) at implantation. Seven patients were implanted within 1 month of their PPCM diagnosis. Median duration of LVAD support was 19 (2–92) months with median follow up of 67 (18–136) months (100% complete). In‐hospital and 1‐year mortality were 0% and 8.3%, respectively. Two patients died on LVAD support, four patients were successfully bridged to transplantation, two patients are still on LVAD, and four were successfully weaned due to sufficient LV recovery (one died after LV function deteriorated again).ConclusionLVAD treatment of decompensated end‐stage PPCM is feasible. Early LVAD provision led to hemodynamic stabilization in our cohort and facilitated safe LV recovery in one third of these young female patients.
SBI is uncommon in the absence of paediatricians' gut feeling and abnormal respiratory pattern
Authors: Cozzi Giorgio , Tessitore Antimo , Giangreco Manuela , Cogo Paola , Valentini Elena , Salis Simona , Pascolo Paola , Barbi Egidio 
Published: September 2022

AbstractAimAccording to the Italian national statistical institute, severe bacterial infections (SBI) in Italy are responsible for 1.7% of mortality under 5 years of age and their recognition is often challenging, especially in the first stages of the disease.We tried to estimate the prevalence of SBI in our target population and to identify signs and symptoms that could guide in the initial evaluation of a child with a possible SBI.MethodsWe designed a prospective, multicentre study and enrolled patients aged 0–14 years at the first evaluation to the emergency department with an acute illness lasting a maximum of 5 days. The presence of variables suggestive of SBI was collected for every enrolled patient. One week after the enrolment, every patient was followed up by telephone.ResultsSBI is more likely to be detected with the ‘gut feeling’ in both univariate and multivariate models (univariate OR: 7.16, 95% CI: 4.08–12.56; multivariate OR: 5.34, 95% CI: 2.78–10.25), while abnormal breathing pattern resulted significative only in univariate model (OR 3.83, 95% CI: 1.98–7.40). Nevertheless, their associated sensitivity is low.ConclusionSBI is uncommon in the absence of paediatricians' gut feeling and abnormal respiratory pattern.
Mold‐deteriorated archaeological Egyptian papyri: Biodeteriogens, monitoring the deterioration, and treatment approach
Authors: Saada Hanadi , Othman Moamen , Khaleil Mona 
Published: September 2022

AbstractFungi play a critical role in the deterioration of ancient papyri due to their organic and hygroscopic nature. Fourteen fungal species belonging to five genera—Aspergillus,Cladosporium,Penicillium,Talaromyces, andUlocladium—were isolated and identified from 20 Egyptian papyrus artifacts located at the Grand Egyptian Museum—Conservation Center (GEM‐CC). The biodeterioration mechanism was evaluated by two analyses: cellulase enzyme activity and acid production assay. The isolated fungusP. lanosumshowed potent biodeterioration power as it exhibited the highest enzymatic activity and could produce acid as well. Four different analyses were performed to assess the entity of the biodeterioration phenomenon: scanning electron microscopy, Fourier transform infrared spectroscopy, colorimetry, and pH measurements. The analyses demonstrated considerable changes in surface morphology, chemical structure (mainly represented by oxidation and hydrolysis of infected papyrus samples), darkness of the papyrus samples (ΔE3.84–7.33), and pH (which dropped to 5.2 in the case ofA. niger‐infected sample. This article builds a preliminary perception for monitoring the biodeterioration of archaeological papyri and a trial for in vitro treatment to prevent further degradation, which may lead to loss of our valuable artifacts over a prolonged period.
Video‐assisted thoracoscopic surgery for pleuroperitoneal communication
Authors: Tsubouchi Hideki , Nakamura Shota , Fukui Takayuki , Kadomatsu Yuka , Ueno Harushi , Ozeki Naoki , Fukumoto Koichi , Mizuno Masashi , Chen‐Yoshikawa Toyofumi F. 
Published: September 2022

AbstractHere we report the cases of five patients on continuous ambulatory peritoneal dialysis (CAPD) who developed hydrothorax because of pleuroperitoneal communication. Preoperative computed tomography (CT) peritoneography revealed penetrated sites on the diaphragm in all patients. All patients underwent video‐assisted thoracoscopic surgery (VATS), and a dialysate containing indigo carmine was injected intraperitoneally through a CAPD catheter to confirm the fistula. In all patients, a thinned bleb was found at the center of the diaphragmatic tendon consistent with that noted on preoperative CT peritoneography. The bleb was resected using a surgical stapler in four patients, and the pleuroperitoneal communication did not recur. However, in one patient, the bleb was only covered with reinforcement agents and the hydrothorax recurred after CAPD. This study demonstrates that VATS treatment for pleuroperitoneal communication is safe and effective but that lesion resection would be more useful for preventing hydrothorax recurrence in patients undergoing CAPD.
Exploring the self‐care practices of social workers in China under the COVID‐19 pandemic
Authors: Li Qing , Xu Liying , Wang Yun , Zhu Yun , Huang Yan 
Published: September 2022

AbstractThe self‐care practices of social workers have garnered increasing attention in the literature, yet little is known about the case of China. To explore the self‐care practices of Chinese social workers under the COVID‐19 pandemic, this study uses the Self‐Care Practice Scale (SCPS) to measure the self‐care practices of social workers (N = 1066) in Fujian Province, China. The results indicate that Chinese social workers engage in moderate amounts of self‐care practices under the COVID‐19 pandemic. Significant group differences exist in social workers' self‐care practices by marital status, parenting status, age, health satisfaction, years of practicing social work, average hours of work per day, resignation intention, job satisfaction, number of received supervision services in a year, and self‐care education. Significant predictors of self‐care include marital status, monthly salary, service status, average hours of work per day, number of received supervision services in a year, school self‐care education, job satisfaction, and health satisfaction. This study has practical implications for self‐care education and practice, including workplace health promotion and the development of self‐care practice policies.
The moderating role of socioeconomic status on the relationship between teacher social support and sense of belonging to school
Authors: Bakchich Julien , Carré Arnaud , Claes Nele , Smeding Annique 
Published: September 2022

AbstractBackgroundTeacher social support (TSS) has been identified as one of the most important factors of success and well‐being for students. Yet, there is a gap in the literature regarding the impact of students' socioeconomic status (SES) on their perceptions of TSS, and whether SES may impact the strength of the relationship between teacher social support and students' sense of belonging to school (SBS).AimsIn this preregistered study, we aimed at filling this gap by testing the moderating role of SES on the TSS‐SBS link, along with the direct associations between these variables.SampleWe used data from the French sample of the Programme for International Student Assessment 2018 (PISA; N = 6308).MethodsTSS was primarily assessed as a latent construct based on three indicators provided by PISA: teacher support, teacher emotional support and teacher feedback. Regarding SES, we primarily focused on family wealth possessions and parents' highest level of education.ResultsUsing structural equation modelling, findings confirmed that the TSS‐SBS link was stronger for high‐SES than low‐SES students. We also found a negative association between teacher support and SES. Importantly, preregistered additional analyses highlight that findings depend on the SES and TSS indicators considered.ConclusionsFindings support the importance of SES effect on students' perceptions of their interactions with teachers and the extent to which they perceive they belong to the school. The implications and limitations of this research are discussed.
Optimizing decision‐making after ventral onlay buccal mucosa graft urethroplasty failure
Authors: Bandini Marco , Basile Giuseppe , Lazzeri Massimo , Montorsi Francesco , Valli Benedetta , Balò Sofia , Barbagli Guido 
Published: September 2022

ObjectivesTo evaluate factors predicting recurrence after treatment and to assess the best rescue option for patients failing buccal mucosa graft (BMG) urethroplasty.Materials and methodsWe evaluated the data from 575 patients treated with ventral onlay BMG urethroplasty. Multivariable Cox regression analysis was performed to identify predictors of BMG urethroplasty failure, and their effect on failure risk was estimated using the Kaplan–Meier method and compared using log‐rank tests. Then, for those patients who underwent a rescue treatment, namely, direct visual internal urethrotomy (DVIU) vs open urethroplasty, we assessed the probability of success after retreatment using the Kaplan–Meier method and regression tree analyses.ResultsOn multivariable Cox regression analysis, only stricture length ≥5 cm (hazard ratio 3.46, 95% confidence interval 1.50–7.94; P = 0.003) was a predictor of failure. A total of 103 patients had at least one re‐intervention. Notably, 12‐month success rates after first rescue DVIU, second rescue DVIU, third rescue DVIU, and fourth rescue DVIU were 66.3%, 62.5%, 37.5% and 25%, respectively. Conversely, for those patients who underwent open urethroplasty retreatment, success rates at 12 months were 83.3%, 79%, 92.3% and 75% after BMG ventral onlay, first rescue DVIU, second rescue DVIU and third rescue DVIU, respectively. These data were confirmed in regression tree analyses.ConclusionVentral BMG urethroplasty fails in approximately one out of five patients. Despite DVIU as a rescue treatment being a good option, its success rate becomes lower as the number of DVIU treatments performed increases. Conversely, open urethroplasty improves patient outcomes in almost three out of four patients, even in the case of previous failed DVIU treatments for stricture recurrence.
Commentary: Using experts by experience to enhance transitional age youth mental health services – a commentary on Adu et al. (2022)
Authors: Wakefield Emma , Wakefield Toni 
Published: September 2022

BackgroundIn their article, ‘System Transformation to Enhance Transitional Age Youth Mental Health – A Scoping Review’, Joseph Adu et al. consider how, over the last 15 years, youth mental health and the transitional age from adolescents to young adulthood has received increasing attention, with 1 in 5 living with mental illness reported as being under 25. Their research on the transition to adult mental health services identifies a need for innovative, evidence‐based approaches to TAY mental health care, in response to the emerging and persistent challenges experienced globally in this area of practice.In responding to this review, the authors support the findings that when youth actively participate in service design, they experience improvements in their own mental health and are able to contribute to the evolution of evidence‐based mental health promotion and care. Examples from personal experience and research reiterate the importance of youth voice through all levels of system design.ConclusionsThe benefits of co‐production are evident, both in this review and from personal experience, recognising that mental health issues have a major impact on individuals, families, and communities. The use of this approach in developing and improving youth mental health transition services is beneficial for all involved.
METTL3‐mediated m6A mRNA contributes to the resistance of carbon‐ion radiotherapy in non‐small‐cell lung cancer
Authors: Xu Xiaofeng , Zhang Peiru , Huang Yangle , Shi Weizhong , Mao Jingfang , Ma Ningyi , Kong Lin , Guo Lin , Liu Jinlong , Chen Jian , Lu Renquan 
Published: September 2022

AbstractLung cancer is one of the leading causes of death among cancer patients worldwide. Carbon‐ion radiotherapy is a radical nonsurgical treatment with high local control rates and no serious adverse events. N6‐methyladenosine (m6A) modification is one of the most common chemical modifications in eukaryotic messenger RNA (mRNA) and has important effects on the stability, splicing, and translation of mRNAs. Recently, the regulatory role of m6A in tumorigenesis has been recognized more and more. However, the dysregulation of m6A and its role in carbon‐ion radiotherapy of non‐small‐cell lung cancer (NSCLC) remains unclear. In this study, we found that the level of methyltransferase‐like 3 (METTL3) and its mediated m6A modification were elevated in NSCLC cells with carbon‐ion radiotherapy. Knockdown of METTL3 in NSCLC cells impaired proliferation, migration, and invasion in vitro and in vivo. Moreover, we found that METTL3‐mediated m6A modification of mRNA inhibited the decay of H2A histone family member X (H2AX) mRNA and enhanced its expression, which led to enhanced DNA damage repair and cell survival.
Bucco‐palatal implant position and its impact on soft tissue level in the maxillary esthetic zone
Authors: Fürhauser Rudolf , Fürhauser Lukas , Fürhauser Nikolaus , Pohl Veronika , Pommer Bernhard , Haas Robert 
Published: September 2022

AbstractAimThe term “buccal implant position” is commonly used but lacks a precise definition and missing a reference point. Considering its major impact on peri‐implantitis and esthetic failures the purpose of this study was to find a correlation between bucco‐palatal implant positioning and the midfacial soft tissue level of implant crowns using newly defined Emergence‐points.Materials and MethodsPatients with unilateral single‐tooth implant crowns in the region of the central or lateral maxillary incisor were included in this study. Digital intraoral scans were superimposed over a scan of the master cast or the original digital data set and analyzed in a computer planning program. In relation to the corresponding natural tooth, an ideal Emergence‐point (EIDEAL‐point) was defined from a frontal view. The distance to the real Emergence‐point (EREAL‐point) of the implant crown was correlated to apical displacement (AD) of peri‐implant soft tissue. The distance of the implant shoulder (I‐point) to the real Emergence‐point (EREAL‐point) of the implant crown was also correlated to the AD of peri‐implant soft tissue. In cross sections, the horizontal distance between EREAL‐ and I‐point represents the sagittal implant position (SIP), and the vertical distance represents the vertical implant position (VIP).ResultsSeventy‐three patients met the inclusion criteria. AD ranged from 0 to 3.5 mm (AD = 0.87 ± 1.01), SIP from 0.2 to 5.1 mm (AD = 2.66 ± 1.64). Statistical analysis showed a significant inverse correlation between AD and SIP (ρ = −.55, p < .001). VIP, the implant inclination, time span since implant insertion, and phenotype revealed no significant correlation to AD.ConclusionThe more palatal the implant was positioned, the less AD was observed. The position of the implant shoulder should preferably be planned more than 2 mm behind the ideal E‐point. This E‐point can be used for implant planning as it defines the ideal crown length for prospective planning.
Anorexia nervosa and autoimmune comorbidities: A bidirectional route?
Authors: Sirufo Maria M. , Magnanimi Lina M. , Ginaldi Lia , De Martinis Massimo 
Published: September 2022

AbstractImmunological dysfunctions in eating disorders have recently gained increasing scientific attention. Furthermore, the reciprocal association between anorexia and autoimmune diseases is of particular interest and suggests a role of autoimmunity in the pathogenesis of eating disorders. Anorexia nervosa (AN) and autoimmune diseases are linked by a bidirectional relationship based on common immunopathological mechanisms. In this review, in addition to reporting the numerous cases described in which autoimmune disorders are associated with anorexia or vice versa, we summarize the many aspects of this relationship between the immune system (IS) and AN. We describe how the microbiota affects the IS, disrupts gut‐brain communication, and possibly triggers eating disorders. We also describe the shared immunological pathways of autoimmune and eating disorders and in particular the occurrence of disrupted T cell tolerance and autoantibodies in AN. The described observations represent the starting point for possible, future research directions.
Collateral damage from agricultural netting to open‐country bird populations in Thailand
Authors: Angkaew Rongrong , Round Philip D. , Ngoprasert Dusit , Powell Larkin A. , Limparungpatthanakij Wich'yanan , Gale George A. 
Published: September 2022

AbstractNets are used across a wide variety of food production landscapes to control avian pests typically resulting in deaths of entangled birds. However, the impact of nets on bird populations is a human–wildlife conflict that remains mostly unquantified. Here, we examined the scale of netting in the central plains of Thailand, a region dominated by ricefields, among which aquaculture ponds are increasingly interspersed. Nets/exclusion types, number of individual birds and species caught were recorded on 1312 road‐survey transects (2‐km length × 0.4‐km width). We also interviewed 104 local farmers. The transect sampling took place in late‐September 2020, and from December 2020 to April 2021. Each survey transect was visited only once. We found 1881 nets and barriers of parallel cords on 196 (15%) of the transects. Counts of nets and barriers were ~13 times higher than expected in aquaculture ponds based on their areal proportion, and vertical nets were the most commonly observed type (n = 1299). We documented 735 individuals of at least 45 bird species caught in the nets and parallel cords, including many species not regarded as pests. Approximately 20% of individuals caught in ricefields and 95% at aquaculture ponds were non‐target bycatch. Our interviews suggested that 55% of respondents thought nets were ineffective while only 6% thought they were effective. We suggest imposing a ban on netting, considering other mitigation strategies to reduce conflicts such as promoting the use of parallel cords, and prioritizing conservation actions with community participation. Further studies should investigate the efficacy of less deleterious deterrents.