bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the El Niño-Southern Oscillation Impact on the Indian Summer Monsoon 1-Dimensional? Quantifying the Role of Antecedent Southwestern Indian Ocean Capacitance on the Variability of Summer Monsoon Rainfall over Homogeneous Regions of India
Authors: Thandlam Venugopal , Rahaman Hasibur , Rutgersson Anna , Sahlee Erik , Muthulagu Ravichandran , SSVS Ramakrishna 
Published: January 2022

Abstract
Recent rapid changes in the global climate and warming temperatures increase the demand for local and regional weather forecasting and analysis to improve the accuracy of seasonal forecasting of extreme events such as droughts and floods. On the other hand, the role of ocean variability is at a focal point in improving the forecasting at different time scales. Here we study the effect of Indian Ocean mean sea level anomaly (MSLA) and sea surface temperature anomalies (SSTA) on Indian summer monsoon rainfall during 1993-2019. While SSTA and MSLA have been increasing in the southwestern Indian Ocean (SWIO), these parameters' large-scale variability and pre-monsoon winds could impact the inter-annual Indian monsoon rainfall variability over homogeneous regions. Similarly, antecedent heat capacitance over SWIO on an inter-annual time scale has been the key to the extreme monsoon rainfall variability from an oceanic perspective. Though both SSTA and MSLA over SWIO have been influenced by El Niño-southern oscillation (ENSO), the impact of SWIO variability was low on rainfall variability over several homogeneous regions. However, rainfall over northeast (NE) and North India (NI) has been moulded by ENSO, thus changing the annual rainfall magnitude. Nevertheless, the impact of ENSO on monsoon rainfall through SWIO variability during the antecedent months is moderate. Thus, the ENSO influence on the atmosphere could be dominating the ocean part in modulating the inter-annual variability of the summer monsoon. Analysis shows that the cooler (warmer) anomaly over the western Indian Ocean affects rainfall variability adversely (favourably) due to the reversal of the wind pattern during the pre-monsoon period.
Psychiatric Comorbidities and Dehydration are More Common in Children Admitted to the Emergency Department for Eating Disorders in the COVID-19 Era.
Authors: Spina Giulia , Roversi Marco , Marchili Maria Rosaria , Raucci Umberto , Fini Francesca , Mirra Gianluca , Testa Giulia , Guarnieri Benedetta , Clemente Anna , Diamanti Antonella , Zanna Valeria , Castiglioni Maria , Vicari Stefano , Reale Antonino , Villani Alberto 
Published: January 2022

Abstract
Purpose Since the beginning of COVID-19 pandemic, social distancing and home-confinement had a significant impact on children, especially on those with eating disorders (ED). The primary objective of this retrospective study was to describe and analyze the demographic and clinical profiles of children presenting with ED during the COVID-19 pandemic.Methods We conducted a retrospective review of clinical charts of patients with ED younger than 18 years who accessed the emergency department of the Bambino Gesù Children's Hospital, Rome, between March 2019 and March 2021. Of these, we reported and compared the demographic, clinical and laboratory data before and after the COVID-19 pandemic and looked for predictors of ED severity.Results A total of 211 admissions for ED were recorded. The patients, mostly females (86.3%) were on average 14.1 years old. The mean weight loss on admission was 11 kg. Bradycardia was observed in 31.3% of the study sample. 16.6% of patients had an associate psychiatric disorder and 60.2% required psychotropic drugs. 68.7% of the patients required hospitalization. Respectively, 96 and 115 patients were admitted before and during the COVID-19 pandemic. The latter were hospitalized more (78.3 vs 57.3%; p=0.001), yet for less time (19 vs 26 days; p=0.004), had a higher mean serum creatinine (0.68 vs 0.47; p<0.001) and were more frequently diagnosed with an associated psychiatric disorder (23.5 vs 8.3%; p=0.003).Conclusion Our study shows a significant increase of hospitalizations of children with ED during the COVID-19 pandemic, along with a shorter length of stay, more psychiatric comorbidities, and some distinctive features at the laboratory workup, such as an increase of serum creatinine and/or a reduction of serum albumin.Level of evidence III, evidence obtained from well-designed cohort or case-control analytic studies
Extreme wind speed prediction in mountainous area with mixed wind climates
Authors: Ma Teng , Cui Wei , Zhao Lin , Ding Yejun , Fang Genshen , Ge Yaojun 
Published: January 2022

Abstract
In addition to common synoptic wind system, the mountainous terrain forms a local thermally driven wind system, which makes the mountain wind system have strong terrain dependence. Therefore, in order to estimate the reliable design wind speeds for structural safety, the samples for extreme wind speeds for certain return periods at mountainous areas can only come from field measurements at construction site. However, wind speeds measuring duration is usually short in real practice. This work proposes a novel method for calculating extreme wind speeds in mountainous areas by using short-term field measurement data and long-term nearby meteorological observatory data. Extreme wind speeds in mountainous area are affected by mixed climates composed by local-scale wind and large scale synoptic wind. The local winds can be recorded at construction site with short observatory time, while the extreme wind speeds samples from synoptic wind climate from nearby meteorological station with long observatory time is extracted for data augmentation. The bridge construction site at Hengduan Mountains in southwestern China is taken as an example in this study. A 10-month dataset of field measurement wind speeds is recorded at this location. This study firstly provides a new method to extract wind speed time series of windstorms. Based on the different windstorm features, the local and synoptic winds are separated. Next, the synoptic wind speeds from nearby meteorological stations are converted and combined with local winds to derive the extreme wind speeds probability distribution function. The calculation results shows that the extreme wind speed in the short return period is controlled by the local wind system, and the long-period extreme wind speed is determined by the synoptic wind system in the mountain area.
Analysis of the Negative Impacts of Coffee Husk on the Local Environment
Authors: Tolessa Berhanu , Amena Berhanu Tolessa , Altenbach Holm , Tibba Getachew Shunki , Lemu Hirpa G. 
Published: January 2022

Abstract
In a locality wherever intense low process is completed while not appropriate waste management measures, low effluents area unit the principal reason behind organic pollution. Low husk contains caffeine, tannins, and chlorogenic acid, creating it a dangerous exposed husk. The low method has been delivery environmental issues to the environment thanks to the discharge of pollution with a large quantity of organic waste. the target of this work is to research the negative impacts of low husk on the atmosphere to scale back environmental pollution in step with the planet Health Organization, one among the foremost vital problems that enterprises confront as they look for ways to limit their use of the artifact by changing it into value-add products/applications is that the harmful impact of low husk on the atmosphere (WHO).The significance of the experiment is to form low husk as an alternate resource to switch fiber. Methylene chloride liquid-liquid extraction was developed to avoid caffeine, tannin, and CGA spectral overlapping within the three hundred -700 nm wavelength vary. The results indicated increment deadly materials that have an effect on the atmosphere. From the experiment performed low husk are often used as an alternate resource for getting composites for might applications and solve the environmental issues.
Influence of A Public Health Emergency On Care For Patients With Duchenne Muscular Dystrophy: An Online, Cross-Sectional Survey
Authors: Zhang Shu , Wang Shaoxia , Dong Yuru , Chen Xinyu , Hu Miao , Kou Sen , Zhang Chunyan , Wu Shiwen , Tian Yaping 
Published: January 2022

Abstract
Background: The public health emergency has created challenges for the care of patients, particularly those with chronic diseases such as Duchenne muscular dystrophy. To elucidate the challenges faced by Chinese patients with Duchenne muscular dystrophy during the public health emergency coronavirus disease 2019 pandemic, we conducted an online cross-sectional survey, the responses of which were collected between March 27 and June 30, 2021. Results: In total, valid questionnaire responses were obtained from 2,105 patients, of whom 49 lived in pandemic lockdown areas. Of the 2,056 responders from non-lockdown areas, 42.8% reduced their outside daily activities, 49.4% reduced their use of rehabilitation services, 39.7% postponed regular follow-up appointments, and 40.8% complained of accelerated declines in motor function over the previous year. The corresponding figures for the 49 participants from lockdown areas were almost all higher, with 67.3% reducing outside daily activities, 44.9% reducing their use of rehabilitation services, 79.6% postponing regular follow-up appointments, and 55.1% complaining of accelerated declines in motor function. When asked whether they expected more assistance from society than they had received before the pandemic, 60.8% of patients in non-lockdown areas and 87.8% of those in lockdown areas responded affirmatively. When asked whether they felt more anxious than they had before the pandemic and needed psychological counseling, 11.5% of respondents in non-lockdown areas and 18.4% of respondents in lockdown areas responded affirmatively. In non-lockdown areas, 76% of respondents had at least one telemedicine visit, and 71% of them thought that telemedicine was helpful. In lockdown areas, 91.8% had used telemedicine at least once, and 66.7% of them found it helpful.Conclusions: These public health emergency control measures have affected the care of patients with chronic diseases worldwide, particularly pronounced in lockdown areas. It is imperative that healthcare workers assist patients and establish more robust chronic disease management systems. Telemedicine is an effective model for providing healthcare to such patients.
Economic Impact and Cost Benefit of the Inpatient Clinical Pharmacist Interventions in Cancer Care Units
Authors: Abushanab Dina , Gulied Amaal , Hamad Anas , Rouf Palli Valappila Abdul , Hail Moza Al , Kassem Wessam El , Hajj Maguy El , Al-Badriyeh Daoud 
Published: January 2022

Abstract
Background: Clinical pharmacists play a key role in ensuring the optimum use of cancer medicines. Yet, the economic benefit of this role has never been assessed in Qatar. Aim: To evaluate the overall economic impact of clinical pharmacist interventions in the main cancer care setting in Qatar. Methods: From the public healthcare perspective, this was an analysis of the total economic benefit and a cost-benefit analysis of the clinical pharmacy interventions. As a study sample size, patient records in March 2018, July/August 2018, and January 2019 were retrospectively reviewed at the National Center for Cancer Care & Research (NCCCR), Qatar. The total benefit from interventions was the total of the cost avoidance due to preventable adverse drug events (ADEs) plus the cost savings associated with therapeutic interventions. The interventions cost was based on salary and increased cost due to therapeutic interventions. The cost-benefit analysis results were presented via net benefit and benefit‐to‐cost ratio measures. Results : Total of 1,352 interventions occurred during the 3-month follow-up period. The total benefit was QAR 196,010,360 (USD53,834,206), constituting cost avoidance of QAR 194,764,534 (USD 53,492,040) and cost savings of QAR 1,245,826 (USD 342,166), mostly due to recommending additional medications and the medication dose reduction. The benefit-to-cost ratio was 174:1 and the annual net benefit was QAR 779,539,440 (USD 214,100,351). Sensitivity analyses confirmed the robustness of results. Conclusion: The clinical pharmacist intervention is a cost-beneficial practice in the NCCCR setting, associated with ADEs prevention and substantial economic benefits, including relative to the interventions cost.
‘Others Will Even Call us Terminators’: Barriers and Facilitators to Provision of Comprehensive Abortion Care (Cac) in Zambia – A Qualitative Study
Authors: PHIRI CHRISTABEL CHIGWE , JACOBS CHOOLWE , SICHONE VICTOR , KAONGA PATRICK , MAKASA MUSONDA , VWALIKA BELLINGTON , KUMWENDA ANDREW , MUKOSHA MOSES , NKOLE THERESA , MUMBA JANE , MUNAKAMPE MARGARATE NZALA , MANGALA BENEDICTUS , MWILA MEEK , LUBEYA MWANSA KETTY 
Published: January 2022

Abstract
Background:It is estimated that one in every five pregnancies globally ends up as abortion, with about 40% being unsafe. Abortions account for approximately 5.9% of all maternal mortalities and 50% of gynaecological admissions in Zambia. Despite implementing Comprehensive Abortion Care (CAC), which aims to provide high quality, safe and affordable services to women, unsafe abortions rates remain high. In this study, we explored the barriers and facilitators to CAC provision in selected health facilities of Lusaka and Copperbelt provinces in Zambia.Materials and methods: A qualitative case study using in-depth interviews with health care providers was conducted between July – August, 2021 in nine selected public health facilities of Zambia. A total of 17 interviews were conducted with participants purposively sampled. The interviews were digitally recorded and transcribed verbatim. Data analysis was done using content analysis. Results: The study revealed a number of barriers and facilitators most of which are health system related. The health system related barriers included inadequate CAC providers, healthcare provider perception that provision of CAC was optional, lack of CAC dedicated space and privacy, frequent shortages of medical supplies and lack of incentives, while individual related barriers included stigma surrounding CAC provision, religious and moral dilemmas. Facilitators to CAC provision included having providers trained and mentored in CAC, availability of a liberal legal framework, accessible services, task shifting and external financial support. Conclusions: The findings of this study on the several barriers of CAC reinforces the idea that despite having appropriate legal provisions to CAC provision in Zambia, challenges in the implementation of the law and related service provision continue to persist. The identified barrriers suggests to consider incorporating CAC services into the pre-service training to ensure more trained and skilled providers are available in the public facilities.
Neoadjuvant Therapy with Doxorubicin-Cyclophosphamide Followed by Weekly Paclitaxel in Early Breast Cancer: A Retrospective Analysis of 200 Consecutive Patients Treated in A Single Center with A Median Follow-Up of 9.5 Years.
Authors: Dredze Lisi M. , Friger Michael , Ariad Samuel , Koretz Michael , Delgato Bertha , Shaco-Levy Ruthy , Tokar Margarita , Bayme Michael , Agassi Ravit , Rosenthal Maia , Dyomin Victor , Beluchitski Olga , Libson Shai , Mizrahi Tamar , Geffen David B. 
Published: January 2022

Abstract
Purpose
We analyzed outcomes of doxorubicin-cyclophosphamide(AC) followed by weekly paclitaxel as neoadjuvant chemotherapy(NAC) for breast cancer(BC), in an everyday practice with long-term follow-up of patients.
Methods
All patients (n=200) who received the AC-paclitaxel combination as NAC for BC at the Soroka University Medical Center from 2003 to 2012 were included in this retrospective cohort study. AC was administered on an every 3-week schedule (standard dose) until May, 2007(n=99); and subsequently every 2 weeks (dose dense)(dd)(n=101). Clinical pathologic features, treatment course and outcome information were recorded. Complete pathologic response(pCR) was analyzed according to BC subtype, dose regimen and stage.
Results
Median age was 49 years; 55.5% and 44.5% of patients were clinically stage 2 and 3, respectively. Standard dose patients had more T3 tumors. Subtypes were human-epidermal-growth-factor receptor(HER 2)-positive 32.5% (of whom 82% received trastuzumab), hormone-receptor positive/HER2 negative 53%, triple negative 14.5%. Breast conserving surgery(BCS) was performed in 48.5% of patients; only 9.5% were deemed suitable for BCS prior to NAC. Toxicity was acceptable. The overall pCR rate was 26.0% and was significantly higher in the dd group and HER2-positive patients. With a median follow-up of 9.51 years median event-free survival(EFS), and overall survival(OS) is 10.85 years and 12.61 years, respectively. Patients achieving pCR had significantly longer EFS and OS.
Conclusions-
NAC for BC with AC-paclitaxel can be safely administered in the “real-world’ setting with high efficacy. Current efforts are aimed at Increasing rates of pCR and identifying patients who may benefit from additional therapy or conversely, de-escalated treatment.
Sow Vaccination Against Virulent Glaesserella Parasuis Shapes the Nasal Microbiota of Their Offspring
Authors: Blanco-Fuertes Miguel , Correa-Fiz Florencia , Lopez-Serrano Sergi , Sibila Marina , Aragon Virginia 
Published: January 2022

Abstract
Glaesserella parasuis is the etiological agent of Glässer’s disease, a common pathology in the pork industry with higher prevalence in the postweaning period. Vaccination is one of the strategies to control this disease. Here, we investigated the effect that sow vaccination against virulent strains of G. parasuis had in the nasal microbiota of their offspring. Nasal swabs from fifteen days-old piglets from vaccinated (vs-P, N=11) and unvaccinated sows (cs-P, N=11) were obtained and DNA was extracted for 16S amplicon sequencing. Microbiota composition was different, with lower diversity in vs-P, and a strong clustering of the groups in beta diversity analysis. Among the 1,509 sequences associated to either study group, all the sequences classified as G. parasuis (N=10) had lower relative abundance in the vs-P group. A list of 32 inferred metabolic pathways were statistically different between groups. A distinctive structure of the two microbial networks was detected, with modules in the cs-P not conserved in the vs-P network. In conclusion, vaccination of the sows had a large effect in the microbiota composition of their offspring that went beyond the effect on the targeted pathogen. The mechanisms underneath these changes may include alteration of the microbiota network due to the elimination of the targeted pathogen and/or immunological changes.
An-Luo-Hua-Xian Pill Can Improve the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated With Entecavir
Authors: Liu Yi-Qi , Zhang Chi , Li Jia-Wen , Cao Li-Hua , Zhang Zhan-Qing , Zhao Wei-Feng , Shang Qing-Hua , Zhang Da-Zhi , Ma An-Lin , Xie Qing , Gui Hong-Lian , Zhang Guo , Liu Ying-Xia , Shang Jia , Xie Shi-Bin , Li Jun , Zhang Xu-Qing , Zou Zhi-Qiang , Chen Yu-Ping , Zhang Zong , Zhang Ming-Xiang , Cheng Jun , Zhang Fu-Chun , Huang Li-Hua , Li Jia-Bin , Meng Qing-Hua , Yu Hai-Bin , Mi Yu-Qiang , Peng Yan-Zhong , Wang Zhi-Jin , Chen Li-Ming , Meng Fan-Ping , Ren Wan-Hua , Bai Lang , Zeng Yi-Lan , Fan Rong , Lou Xian-Zhi , Liang Wei-Feng , Liu Hui , Zhuang Hui , Zhao Hong , Wang Guiqiang 
Published: January 2022

Abstract
Background & Aims: Chronic hepatitis B (CHB) can cause liver fibrosis and lead to cirrhosis even cancer, antiviral therapy can reverse liver fibrosis with limited effect, thus we aimed to evaluate the effect of An-Luo-Hua-Xian pill (ALHX) on fibrosis regression in CHB patients treated with ETV.Methods: Treatment naïve patients with CHB from Oct 1st, 2013 to Dec 31st, 2020 were randomly treated with ETV alone or combined with ALHX (ETV+ALHX). Patients’ demographic, laboratory and liver histology data before and after 78 weeks of treatment were collected. Ishak fibrosis score (F) was used and fibrosis regression means F decreased ≥1 after treatment.Results: In total, 394 patients with a second liver biopsy after treatment were included in per-protocol population: 132 patients in ETV group and 262 patients in ETV+ALHX group. After 78 weeks of treatment, the fibrosis regression rate in the ETV+ALHX group were significantly higher than ETV group in baseline F≥3 patients: 124/211 (58.8%) verse 45/98 (45.9%), p=0.035. The degradation rate of liver stiffness measurement (LSM) is also consistent with it: 154/262 (73.0%) in ETV+ALHX group and 60/132 (61.2%) in ETV group, p=0.037. Logistic regression analysis showed that combined with ALHX was related to fibrosis regression (OR=1.94, p=0.018), and family history of hepatocellular carcinoma was on the contrary (OR=0.41, p=0.031).Conclusions: ETV combined with ALHX can significantly increase liver fibrosis regression in CHB patients.
Assessment of Anthelmintic Property and Insilico study of phytocompounds in roots of Dechaschistia crotonifolia Wight &amp; Arn.
Authors: Peeriga Raveesha , Adarapu Keerthi Priyanka , Sanivar Kavya Sri , Kanumuri Jyothsna , Akunuri Rikith Swamy , Atmakuri Lakshmana Rao 
Published: January 2022

Abstract
Background:Worm infections in developing countries were reported high. Phytoconstituents have been a vital role for the treatment of many ailments. The current study was aimed assess for anthelmintic activity of different root extracts of Dechaschistia crotonifolia Wight & Arn. belongs to the family Ebanaceae against Pheretima posthuma. Further Insilico study was carried out for phytocompounds present in Dechaschistia. Results: The chloroform, ethylacetate and ethanol extract of Dechaschistia crotonifolia Wight & Arn. were considered for the study of anthelmintic property on earthworms at concentrations 20 mg/ml, 40 mg/ml and 60 mg/ml. During this study, the parameters paralysis time (Pt) and Death Time (Dt) of adult Indian earthworms was observed. As a standard and control Albendazole 10 mg/ml and 2% Tween 80 in distilled water were taken respectively. The study resulted that ethanolic extract was significant when compared with the Albendazole 10 mg/ml. Docking studies revealed the all phytocompounds in Dechaschistia shown binding affinity, however comparatively scopoletin and stigmasterol had shown a good binding affinitiy about -7.7 Kcal/mol and -7.6 Kcal/mol compared to standard drug Albendazole which was shown about -8.7 Kcal/mol. Conclusion: The study revealed that the ethanol extract of Dechaschistia crotonifolia Wight & Arn. at a concentration of 60mg/ml exhibited a stronger anthelmintic property compared to Albendazole 10mg/ml. A dose dependent anthelmintic activity is exerted by all the extracts in an ascending manner Chloroform<Ethyl acetate<Ethanol. These observations were made evidenced by docking studies of phytocompounds in Dechaschistia as the phytocompounds were shown excellent docking score when compared with standard Albendazole.