bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Profiling of c-Jun and JunB transcription factor binding sites in an ALK+ ALCL cell line
Authors: Wu Zuoqiao , Nicoll Mary , Facundo Farynna Loubich , Zhang Jingxi , Ingham Robert J. 
Published: June 2022

AbstractAnaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is a T cell lymphoma which features translocations or inversion involving the ALK tyrosine kinase gene, and results in oncogenic fusion proteins (e.g. NPM-ALK). The elevated expression and/or activation of activator protein-1 (AP-1) transcription factors, c-Jun and JunB, is another molecular feature of ALK+ ALCL. c-Jun/JunB transcriptional targets are important in the pathobiology of this lymphoma, and several are also therapeutic targets. To better understand c-Jun/JunB function in ALK+ ALCL, we performed chromatin immunoprecipitation–sequencing experiments in the Karpas 299 ALK+ ALCL cell line to comprehensively identify sites bound by these transcription factors. We identified 13,083 c-Jun and 40,369 JunB binding sites, and ∼60% of sites bound by c-Jun were shared with JunB. Many sites were associated with genes known or predicted to be important in the pathogenesis of ALK+ ALCL. Pathway enrichment analysis of genes associated with both c-Jun and JunB binding sites revealed a significant over-representation for pathways associated with cancer and cell signalling. Furthermore, we identified several c-Jun and JunB binding sites associated with the NIBAN2/FAM129B gene. FAM129B is a PH domain-containing phosphoprotein that promotes proliferation in multiple cell types. However, while we found that FAM129B knock-down resulted in modest cell cycle alteration in most ALK+ ALCL cell lines, this did not appear to result in a significant proliferation defect. Finally, we found that inhibition of NPM-ALK and MEK/Erk signalling altered FAM129B electrophoretic mobility and decreased phosphorylation of FAM129B on serine residues known to be Erk phosphosites. In summary, this study is the first to globally profile sites bound by c-Jun/JunB in ALK+ ALCL. It reveals novel putative targets for these transcription factors in ALK+ ALCL, and identifies FAM129B as a novel phosphoprotein downstream of NPM-ALK signalling.
Salicaceae as potential host plants ofXylella fastidiosain European temperate regions
Authors: Casarin Noemi , Hasbroucq Séverine , Pesenti Lena , Géradin Amandine , Emond Amélie , López-Mercadal Júlia , Miranda Miguel Ángel , Grégoire Jean-Claude , Bragard Claude 
Published: June 2022

ABSTRACTThe discovery of three subspecies ofXylella fastidiosain Europe has triggered major attention on the potential spread up North of the bacteria. Assessing the susceptibility of a previously unexposed European flora is a key element that remains widely unknown. Under biosafety facility, we evaluated the susceptibility of Salicaceae such asPopulus tremula, Populus canescens, Salix albaandSalix capreaby mechanically inoculating the KLN59.3 GFP-labelledX. fastidiosaat 22 °C and at 28 °C. Bacterial movement and multiplication in plants were investigated by PCR, real-time PCR, confocal or scanning electron microscopy. Nine months post-inoculation, 100 % of the plants tested positive forX. fastidiosa, with the exception of 57% forP. canescensunder the 22 °C-growing conditions. Bacteria were detected up to 120 cm from the inoculation point forS. alba. They were detected in the roots of all species and were successfully isolated forS. albaandP. tremula. Estimates of average CFU/g of plant tissue per species ranged from 1.5E + 03 to 3.5E + 06, with the lowest figures forP. canescensand the highest forP. tremulatogether with high number of totally obstructed vessels observed by confocal microscopy. The possibility of insect transmission was also evaluated using an experimental set up based on Mallorca Island. There, transmission byP. spumariusof bothX. fastidiosaST1 and ST81 was proven onS. alba. We thus demonstrated that indigenous European Salicaceae such asS. albaorP. tremulaare new potential hosts forX. fastidiosa.
Women directors, educational background and firm value of Spanish listed companies
Authors: Molinero-Díez Patricia , Blanco-Mazagatos Virginia , Garcia-Rodriguez Inigo , Romero-Merino M. Elena 
Published: June 2022

Purpose
This study aims to evaluate changes in the presence of women on Spanish boards after the Unified Good Governance Code of Listed Companies (2006) and the Organic Law 3/2007 on Gender Equality, and this study compares the educational background of women and men directors. Also, this study analyses the influence of gender diversity and educational background of women directors on economic performance, corporate social responsibility (CSR) and, ultimately, firm value. In addition, this study explores the differences in board gender composition and its effect on firm value during the crisis and post-crisis periods. Finally, this study analyses the different influence of women directors depending on their typology.

Design/methodology/approach
This study uses a system of structural equations and a sample of 4,101 directors of 30 Spanish companies listed on IBEX-35 over 2008–2017.

Findings
The results show that women’s presence on boards has grown since 2008, and they have higher educational background than men. This study finds that women directors improve economic performance and CSR, though results are non-significant for firm value. Women directors with a bachelor’s or master’s degree increase economic and social performance but reduce firm value. Women directors with business or industry-related studies positively influence CSR but business specialisation negatively affects economic performance and firm value.

Originality/value
This study analyses the direct and indirect effect of women directors on firm value, the influence of their educational background and the potential differences arising from the economic situation (crisis) and the type of board position they hold.
An institutional theory perspective on the role of project management associations for projectification of society: the case of Germany
Authors: Wagner Reinhard , Huemann Martina , Radujković Mladen 
Published: June 2022

PurposeThis paper aims to provide insights into the role of project management associations for the projectification of society from an institutional theory perspective.Design/methodology/approachThe paper is based on a mixed methods approach. It draws on the research propositions of a recently conducted qualitative study and builds on them by analyzing the empirical data of a quantitative case study.FindingsThe results indicate that the projectification of society in Germany is well advanced and continues growing. The economy plays a leading role, which resonates with other sectors of society. The actions of project management associations have only an indirect influence on the projectification of society, which cultural–cognitive institutions are mediating. Both findings are novel compared to the literature.Practical implicationsTaking an overall view of the findings, project management associations gain a better understanding of the projectification process and important guidance on their role.Social implicationsThe results offer all people interested intriguing insights into the contemporary phenomenon of the projectification of society, along with its current state and future evolution.Originality/valueThe application of institutional theory to the projectification of society in the framework of this case study enables an in-depth analysis of the underlying social processes and interactions between the regulative, normative and cultural–cognitive activities of project management associations on the one hand, and institutions on the other hand, at the societal level. This opens up new and promising perspectives for further research.
What do expectations change? Optimistic expectations, job crafting, job satisfaction and a new theoretical model
Authors: Yeşilkaya Mukaddes , Yıldız Tayfun 
Published: June 2022

Purpose
The purpose of this study is to determine the effect of optimistic expectations on job satisfaction at work and whether job crafting behaviour plays a mediating role in this effect. At the same time, this model presents the need for “expectation management” in the context of work psychology to the attention of all academics and practitioners.

Design/methodology/approach
To test the hypotheses of the study, data were obtained from 475 health-care workers in a public hospital. Hypotheses were tested using Process Macro Model of Hayes (2018).

Findings
The result of the analyses determined that the optimistic expectations for the organization as a whole have a positive effect on job satisfaction, both directly and indirectly, and that job crafting behaviour has a partial mediating role in this effect.

Research limitations/implications
The first limitation is that the data were obtained only by a cross-sectional method. The second is that among the various workplace behaviours and workplace psychologies job crafting and job satisfaction were examined in the study. The partial mediation effect between the research variables reveals the existence of many other variables and constitutes the third limitation. The fourth is that only optimistic expectations effects on positive behaviours and positive psychological states were evaluated in this study. Finally, a fifth limitation of this study is that the sample is limited to those working in the health sector and public hospitals.

Practical implications
First, the data were obtained only by a cross-sectional method, and the longitudinal method was not implemented in how the study was designed. Second, among the workplace behaviours, only job crafting behaviour and only job satisfaction as a workplace psychology were analysed. Third, partial mediation effect was found to be among the other variables might indicate the role of additional variables that could be uncovered by further research. Fourth, only optimistic expectations and their effects on positive behaviours and positive psychological states at the workplace were evaluated. Fifth, the sample is limited to those working in the health sector and public hospitals.

Social implications
This study draws attention to “Expectation Management” as a management activity worth exploring and its potential in terms of social and working relations.

Originality/value
This study provides versatile answers to the question of why individuals perform differently despite working under the same conditions. The model suggested in the study takes the conventional way of thinking in the literature one step further by offering an alternative answer to this critical question, whose answers we have been discovering step by step since the Hawthorne studies. In addition, the proposed model draws attention to the need for “expectation management” in the context of business psychology in theory and practice.
Social capital and loan credit terms: does it matter in microfinance contract?
Authors: Iqbal Zahid , Rao Zia-ur-Rehman 
Published: June 2022

PurposeTo enhance the loan repayment performance of microfinance institutions (MFIs) in Pakistan, this study aims to analyze the direct impact of social capital and loan credit terms on loan repayment performance and microenterprises’ business performance while considering the mediating role of microenterprises’ business performance on the relationship between social capital, loan credit terms and loan repayment performance.Design/methodology/approachThe analysis was conducted based on the data gathered via a questionnaire distributed to 316 microenterprises owners. The respondents were selected using the stratified sampling technique by dividing the target population into three influential groups of manufacturing, trading and services microenterprises. The reliability and validity of the constructs were established using (1) factor loading, (2) Cronbach’s alpha, (3) composite reliability, (4) average variance extracted, (5) the variance inflation factor, (6) the Fornell–Larcker criterion and (7) the heterotrait–monotrait ratio. The structural equation modeling technique was then applied, and the hypotheses were tested based on the structure model generated through bootstrapping by using partial least squares structural equation modeling.FindingsThe results confirm the direct impact of social capital and loan credit terms on microenterprises’ business performance and loan repayment performance. It also supports the mediating role of microenterprises’ business performance toward the relationship between social capital, loan credit terms and loan repayment performance while considering the direct impact of microenterprises’ business performance on loan repayment performance.Originality/valueTo date, the direct impact of social capital and loan credit terms on microenterprises’ business performance and loan repayment performance has been hardly investigated in the context of Pakistan. This study also examines the mediating role of microenterprises’ business performance toward social capital, loan credit terms and loan repayment performance. The findings will enable both MFIs and microenterprises to improve their business performance and loan repayment performance through enhanced social ties and the development of more flexible credit products that protect the borrowers’ interests and the interest of lenders.
Health insurers: evolving into ecosystem-based service companies
Authors: Jahn Justin , Bohnet-Joschko Sabine 
Published: June 2022

Purpose
This study aims to investigate whether health insurers are transforming from pure payers into ecosystem-based health service companies. The authors discuss the findings’ impact on health insurers’ business model approach and their sources of competitive advantage.

Design/methodology/approach
The authors conducted a multiple case study of 25 incumbent and rising health insurers from the USA, Europe and Asia-Pacific. The selection of firms was based on databases from Forbes, S&P Global Market Intelligence and Crunchbase. By performing a review of financial reports, app descriptions, corporate websites and media coverage, the authors analyzed health insurers’ digital service offerings and underlying strategic approaches for providing those services.

Findings
This study demonstrates that major health insurers are transforming into ecosystem-based health service companies. They expand the traditional insurance value chain by offering value-adding health services along the patient journey. The analysis results are summarized in a table displaying 18 digital service categories along core patient journey phases with corresponding examples of health insurers and underlying strategic approaches.

Originality/value
The role of digital services and ecosystems has been explored for many industries. This study investigates this subject area with a focus on the health insurance sector, advancing a young field of research. The analysis gives insights into the latest digital service offerings and strategic approaches of an internationally diverse set of incumbents and rising ventures.
Quantifying the impact of early-stage maintenance clustering
Authors: Agergaard Julie Krogh , Sigsgaard Kristoffer Vandrup , Mortensen Niels Henrik , Ge Jingrui , Hansen Kasper Barslund 
Published: June 2022

PurposeThe purpose of this paper is to investigate the impact of early-stage maintenance clustering. Few researchers have previously studied early-stage maintenance clustering. Experience from product and service development has shown that early stages are critical to the development process, as most decisions are made during these stages. Similarly, most maintenance decisions are made during the early stages of maintenance development. Developing maintenance for clustering is expected to increase the potential of clustering.Design/methodology/approachA literature study and three case studies using the same data set were performed. The case studies simulate three stages of maintenance development by clustering based on the changes available at each given stage.FindingsThe study indicates an increased impact of maintenance clustering when clustering already in the first maintenance development stage. By performing clustering during the identification phase, 4.6% of the planned work hours can be saved. When clustering is done in the planning phase, 2.7% of the planned work hours can be saved. When planning is done in the scheduling phase, 2.4% of the planned work hours can be saved. The major difference in potential from the identification to the scheduling phase came from avoiding duplicate, unnecessary and erroneous work.Originality/valueThe findings from this study indicate a need for more studies on early-stage maintenance clustering, as few others have studied this.
How do we design and conduct cross-language research? A reflexive approach building on Squires' criteria
Authors: Jeong Daeul 
Published: June 2022

PurposeThis paper demonstrates complexity surrounding cross-language research involving an interpreter and illustrates how the author attempted to ensure methodological rigor through modifying and applying Squires' criteria to the design and conduct of her education research.Design/methodology/approachThis research employed Squires' recommendations for cross-language research as methodological guidelines for designing and conducting cross-language research. The research involved focus group discussions with teachers working in an ethnic minority boarding school in Laos and an interpreter who helped translating/transcribing interviews in Lao to English and data analysis.FindingsFrom applying Squires' criteria, this paper introduces a reflexive set of recommendations for researchers conducting a wide range of qualitative cross-language research.Originality/valueMost meta-criteria for cross-language research are developed to evaluate the quality of cross-language research. However, the soundness of a set of meta-criteria as one tool to evaluate all cross-language research might be questionable due to qualitative studies' diverse epistemological grounds. This paper argues that meta-criteria can serve as a critical and reflexive guide for cross-language researchers when used from the research design and on. The paper also suggests a new set of recommendations which may facilitate more reflexive approaches to cross-language research.
Ensuring brand loyalty for firms practising sustainable marketing: a roadmap
Authors: Khandai Sujata , Mathew Jones , Yadav Renu , Kataria Sonia , Kohli Harpuneet 
Published: June 2022

Purpose
The purpose of this paper is to explore the impact of sustainable marketing practices of firms on consumers’ attitudinal and behavioral brand loyalty. In addition, this study also aims to explore the mediating effect of brand trust and brand affect on this relationship.

Design/methodology/approach
A combination of descriptive and causal research has been used, for which data was collected from 582 respondents and processed using structural equation modeling to establish multivariate relationships. The PROCESS method was used to estimate mediation effects.

Findings
A rather valuable insight that emerged is the significant role that brand trust and brand affect play in engendering attitudinal and behavioral brand loyalty among consumers, for firms adopting sustainable marketing practices. Findings revealed that sustainable marketing practices result in enhanced brand trust, which further translates into higher levels of brand affect, thereby leading to attitudinal brand loyalty and further resulting in behavioral brand loyalty. This study also highlights the importance of brand affect in developing enduring behavioral brand loyalty.

Research limitations/implications
Consumers today are changing their consumption habits, preferring to satisfy ideological and symbolic needs rather than just rational needs. So, marketers practising sustainable marketing should aim to leverage brand trust and brand affect to ensure lasting behavioral brand loyalty.

Originality/value
The examination of the effect of sustainable marketing practices on brand-related variables has contributed to a better understanding of the mechanism that underlines the operation of emotion-based enduring loyalty. The vast majority of studies that provided insights about sustainable marketing practices and consumer behavior thereof were dominated by European and American perspectives and very few studies exist with a focus on developing economies. This study attempts to fill this void by exploring the personal care market in India.
Clinical utility of p16/Ki67 dual‐stain cytology for detection of cervical intraepithelial neoplasia grade two or worse in women with a transformation zone type 3: A cross‐sectional study
Authors: Gustafson Line Winther , Tranberg Mette , Christensen Pia Nørgaard , Brøndum Rikke , Wentzensen Nicolas , Clarke Megan A. , Andersen Berit , Petersen Lone Kjeld , Bor Pinar , Hammer Anne 
Published: June 2022

AbstractObjectiveTo evaluate the clinical utility of p16/Ki67 dual‐stain (DS) compared with cytology for detecting cervical intraepithelial lesion grade two or worse (CIN2+) in women with a transformation zone type 3 (TZ3).DesignCross‐sectional study.SettingColposcopy clinics in Central Denmark Region.PopulationWomen aged 45 years or older referred for colposcopy because of an abnormal screening test.MethodsAll women had a cervical sample collected for cytology and DS testing and underwent large‐loop excision of the transformation zone (LLETZ).Main outcome measureSensitivity, specificity and negative (NPV) and positive (PPV) predictive values of DS for CIN2+ detection were compared to those of cytology.ResultsOf 166 women eligible, 93 (56.0%) were included in the final analysis. Median age was 68 years (interquartile range [IQR] 63.4–70.5 years). Most women were postmenopausal (95.7%) and referred based on a positive human papillomavirus screening test (86.0%). Fifty‐two women (55.9%) were DS‐positive, 29 (55.8%) of whom had CIN2+ detected. Twenty‐seven (29.0%) women had atypical squamous cells of undetermined significance or worse (ASC‐US+), and CIN2+ was detected in 21 women (77.8%). DS had a higher sensitivity (96.7% versus 70.0% p = 0.021) and NPV (97.6% versus 86.4%, p = 0.018) compared with cytology for CIN2+ detection. In contrast, the specificity (63.5% versus 90.5% p < 0.001) and PPV (55.8% versus 77.8%, p = 0.001) were lower for DS compared with cytology.ConclusionsDual stain may be a valuable risk marker to guide clinical management of women with a TZ3. The superior NPV of DS suggests that a diagnostic excision may safely be avoided in DS‐negative women.