bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Friction and Pore-Fluid Pressure Conditions Controlled by Fault Mineral Composition Affect Earthquake Rupture Propagation
Authors: Tsuda Kenichi , Hirono Tetsuro 
Published: November 2022

Abstract
Although direct recovery of frictional features of fault rocks through drilling projects and multiple experimental analyses, such as the Japan Trench Fast Drilling Project and the Nankai Trough Seismogenic Zone Experiment have been recently performed, the conditions of rupture propagation to levels of friction and pore-fluid pressure remains uncertain. In order to invest such issues, we performed dynamic rupture simulations based on experimental friction datasets measured in fault rocks on the Nankai Trough that was ruptured during the 1944 Mw8.0 Tonankai earthquake. A steady-state friction triggered large slip (about 30 m) near the trench, whereas a high friction suppressed the rupture. The condition in which the pore-fluid pressure was nearly equal to the lithostatic stress decreased the slip about 25 m in case of low friction. However, in case of high friction with negative stress drop, the slip reached to around 20 m, because the low shear strength did not arrest the inertial motion of rupture propagation. Such differences in fault-rock properties and fluid conditions, controlled by fault mineral composition, may fundamentally influence on the complexity and the variability of rupture propagation.
A novel candidate gene CLN8 regulates fat deposition in avian
Authors: Li Xiaoqin , Zhang Fan , Sun Yunxiao , Sun Dandan , Yang Fangxi , Liu Yongtong , Hou Zhuo-cheng 
Published: November 2022

Abstract
Background
The fat deposition has a crucial role in animal meat flavor, and fat deposition-related traits are vital for breeding in the commercial duck industry. Avian fat-related traits are typical complex phenotypes, which need a large amount of data to analyze the genetic loci.
Results
In this study, we newly phenotyped fat traits and genotyped whole-genome variations for 1246 ducks, and combed with previous GWAS data to reach 1880 ducks for following analysis. The carcass composition traits, subcutaneous fat weight (SFW), subcutaneous fat percentage (SFP), Abdominal fat weight (AFW), Abdominal fat percentage (AFP) and the body weight of day 42 (BW42) for each duck were collected. We identified a set of new loci that affect the traits related to fat deposition in avian. Among these loci, Ceroid-lipofuscinosis, neuronal 8 (CLN8) is a novel candidate gene controlling fat deposition. We investigated its novel function and regulation in avian adipogenesis.Five significant SNPs and a single haplotype were detected in the upstream of gene CLN8 and the most significant SNP (P-value = 21.37E-12) for subcutaneous fat percentage was obtained. Subsequently, luciferase assay demonstrated that five linkage mutations in the upstream of the CLN8 gene significantly decreased the transcriptional activity of CLN8. Further, ATAC-seq analysis showed that transcription factor binding sites were identified in a region close to the haplotype. A set of luciferase reporter gene vectors that contained different deletion fragments of the CLN8 promoter were constructed, and the core promoter area of CLN8 was finally identified in the − 1884/-1207 bp region of the 5′ flanking sequences, which contains adipogenesis-related transcription factors binding sites. Moreover, the over-expression of CLN8 can remarkably facilitate adipocyte differentiation in ICPs. Consistent with these, the global transcriptome profiling and functional analysis of the over-expressed CLN8 in the cell line further revealed that the lipid biosynthetic process during the adipogenesis was significantly enriched.
Conclusions
Our results demonstrated that CLN8 is a positive regulator of avian adipocyte differentiation. These findings identify a novel function of CLN8 in adipocyte differentiation, which provides important clues for the further study of the mechanism of avian fat deposition.
What facilitators and barriers might researchers encounter when using reporting guidelines? Part 1: A thematic synthesis
Authors: Harwood James , Albury Charlotte , de Beyer Jennifer Anne , Bian Zhaoxiang , Duan Yuting , Kirtley Shona , Schlussel Michael , Zhao Lingyun , Collins Gary S 
Published: November 2022

Abstract
Background
Despite endorsement by medical journals, reporting guidelines have only modestly affected reporting quality. We aimed to identify facilitators and barriers that researchers might encounter when using reporting guidelines.
Methods
We searched MEDLINE, Embase, PsychINFO, AMED, WHO Global Index Medicus, SciELO, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang Data, VIP Chinese Medical Journal Database, OSF, and MiRoR for research that collected qualitative data to explore researchers’ experiences of using reporting guidelines, published after 1996 in English, Chinese, Spanish, or Portuguese. We appraised studies using CASP-Qual. For thematic synthesis, we applied descriptive codes to all sentences that reported qualitative findings, then aggregated codes inductively into descriptive themes that captured the codes’ meaning. We interpreted and contextualised possible facilitators and barriers from these descriptive themes to create analytic themes.
Results
From 18 eligible studies, we developed 12 analytic themes. 1) Researchers may not understand guidance as intended. 2) Researchers report many reasons for using reporting guidelines, and that some are more important than others. 3) Researchers use reporting guidelines for different tasks and want guidance to be delivered in ways that fit their needs. 4) Using reporting guidelines has costs which researchers may feel outweigh benefits. 5) Reporting guidelines may need to be revised and updated for different reasons. 6) Researchers report feeling uncertain or worried if they are unable to report all items. 7) Awareness and accessibility may limit reporting guideline usage. 8) Reporting guidelines may be most beneficial to less experienced researchers, but these researchers may find them harder to use. 9) Researchers seek design advice but reporting guidelines may not be the right place to find it. 10) A reporting guideline's scope must be well-balanced and well-defined. 11) Researchers may have to use multiple reporting guidelines, multiplying complexity and costs. 12) Researchers may use checklists but never read the full guidance.
Discussion
Few reporting guidelines have been evaluated qualitatively. Many studies used surveys which resulted in thin data and were subject to recall bias. Nevertheless, we identified many potential barriers and facilitators. Our findings will help guideline developers and advocates improve reporting guidance dissemination.
Comparison of magnesium status using 24-hour urine magnesium content and magnesium fraction excretion in PCOS with non-PCOS control women: A cross-sectional study
Authors: Abbasi Saeed , Mohebbi Masoud , Vahed Seyedeh Houra Mousavi , Moghaddam Maliheh Dadgar , Afiat Maliheh , Nematy Mohsen , Jahanpak Nafiseh 
Published: November 2022

Abstract

Objective. Magnesium (Mg) is the second most frequent intracellular cation, have an important role in normal enzyme function and insulin secretion. Polycystic Ovarian Syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age and often associated with insulin resistance. Two systematic reviews and meta-analyses have been conducted to compare mean serum Mg levels between PCOS and control groups. Both studies detected unexplained heterogeneity among input studies and the two conclusions contradict each other; while approximately 1% of total body Mg is present in Extracellular Fluid (ECF) and serum Mg level does not represent Mg status well. For the first time, we investigated Magnesium renal Fraction Excretion (FEMg) and compared mean values between PCOS and non-PCOS control women.
Design.Cross-sectional analysis.
Setting. Academic medical center. Population. 44 women were included in PCOS group based on Rotherdam criteria and 50 non-PCOS women in control group.
Method. Statistical analysis of the relationship between 24-hour urinary Mg content, FEMg, and also physical and metabolic variables. The STROBE guidelines for cross-sectional study was followed.
Main outcome measurements. 24-hour urinary Mg content, FEMg.
Results.Mean values of 24-hour urinary Mg content and FEMg did not significantly differ between PCOS and control groups (P=0.22 and P=0.24, respectively). Also serum Mg levels were similar between the groups (P=0.17).
Conclusion. Our data did not suggest Mg play a role in PCOS pathogenesis. For further investigation, we recommend using FEMg for evaluating Mg status rather than serum Mg levels.
Clinical characteristics of a group of HIV patients with ocular lesions
Authors: Che Xin , Zhang Yang , Li Qingjian , Suo Jinshan , Wang Luoziyi , Wang Zhiliang 
Published: November 2022

Abstract
Background: The study was to analyze HIV dynamics across BRB and the relevant risk factors for HIV-associated ocular complications.
Methods: This study included a prospective case series of 40 HIV-positive patients with ocular lesions. Clinical and laboratory examinations included plasma and intraocular VL were evaluated.
Results: HIV VL on paired aqueous/plasma samples was available for 40 patients. Aqueous VL was negatively associated with ART duration (p = 0.02 and p < 0.05), plasma VL was independent of ART duration (p = 0.53). An aqueous/plasma discordance was found in 19/40 (47.5%) patients, eight of whom (20%) had detectable aqueous VL despite a suppressed plasma VL (escape). There were significant differences in CD4+ T-lymphocyte levels (p=0.012 and p < 0.05) and ART duration (p=0.007 and p < 0.05) between the patients with HIV-associated ocular complications and the patients without.
Conclusion: This study provides rationale for initiating ART early in the course of infection to reduce HIV VL in the aqueous humor, and raises the possibility of the ocular sanctuary where HIV replicate. Meanwhile, early and standard ART would be optimal option to protect against ocular opportunistic infection.
Trial registration: Participants enrolled in the research signed informed consent and the study was approved by the institutional ethics committee of Huashan Hospital affiliated with Fudan University (protocol number: KY2021-837).
The value of high-risk HPV E6/E7 mRNA test positivity with NILM cytology in detecting cervical squamous intraepithelial lesions and cervical cancer
Authors: Liu Ying , Jin Xiu , Gong Yingying , Ma Yingying , Du Beibei , Yang Linqing , Wang Yunfei , Zhu Weipei 
Published: November 2022

Abstract

Background: The number of patients who use E6/E7 mRNA for HPV testing is increasing yearly in China.However, there is a lack of uniform clinical standards and guidelines for the management of HPV E6/E7 mRNA-positive patients.This study aimed to assess the value of an HPV E6/E7 mRNA assay and HPV 16 18/45 genotype assay combined with age stratification for triaging women negative for intraepithelial lesions or malignancy (NILM) cytology.
Methods: From January 2017 to December 2021, a total of 162309 eligible women underwent cervical cancer screening at the Affiliated Hospital of Jining Medical University, China. Excluding those with negative HPV E6/E7 mRNA, abnormal and unsatisfactory cytology, and those who failed to undergo colposcopy, 6845 women were ultimately included in our study. We analysed the triage guidance for different subtypes of HPV in the presence of NILM cytology.
Results: Among 162309 women, 19834 (12.2%) were positive for HPV E6/E7 mRNA. Of the 6845 women included in the study, 1941 (28.4%), 561 (8.2%), 55 (0.8%) and 4,288 (62.6%) tested positive for HPV 16, HPV 18/45, HPV16/18/45 or other HR-HPV genotypes, respectively. The proportions of LSIL+ (including LSIL, HSIL and ICC) and HSIL+ (including HSIL and ICC) pathological results in the HPV 16/18/45+ group were 57% and 34.1%, respectively, higher than 36.3% and 11% in the other HR-HPV+group (c2 =653.214, P<0.001). The percentages of LSIL+ and HSIL+ in the HPV16+ group (61.3% and 42.8%, respectively) and HPV16+/18/45+ group (76.3% and 41.9%, respectively) were much higher than those in the HPV18+ group (40.6% and 13.1%, respectively) (P<0.001). However, there was no significant difference in the percentage of histopathological results between the HPV16+ group and HPV16+/18/45+ groups (P>0.05). The above results were consistent after stratification according to age.
Conclusions: The rate of histopathological abnormalities was still high for the other HR-HPV subtypes with NILM cytology, although the rate of histopathological abnormalities was much higher for the HPV 16/18/45 positive subtypes. Therefore, colposcopy should be performed in women with HPV E6/E7 mRNA positivity and NILM cytology, regardless of age and HPV genotype.
A study of aerosol impacts on clouds and precipitation development during an extreme rainfall event over Far-North Cameroon using WRF-Chem
Authors: Djomou David , Meukaleuni Cyrille , Tanessong Romeo S. , Betant Carine A. , Ndao Sémou , Ngongang Rinelle Djiondo , Lenouo Andre 
Published: November 2022

Abstract

An unusual extreme rainfall occurred in far-north Cameroon on August 2020. The monthly accumulated rainfall observed, exceeded 274 mm and the main rainfall time occurred during the third week of this month with a total accumulated rainfall of 80 mm. The Weather Research and Forecasting Model coupled with Chemistry (WRF-Chem) was used to investigate the effects of aerosols on the cloud properties, radiative flux, and precipitations over this region. Three sensitivity tests were designed by varying the anthropogenic emissions. Increased aerosol number concentration has resulted in more numerous cloud droplets of smaller size, through which the optical properties of clouds have been changed. Both shortwave and longwave cloud forcing are decreased in more polluted tests while the net radiative cloud forcing is increased causing an overall warming effect. The cloud and ice water content increased while the rainwater content decreased in the more polluted tests. It is found that; cloud fraction is reduced in more polluted atmospheres. The domain-averaged accumulated rainfall in the clean and polluted tests decreased compared to that in the control test and the maximum accumulated rainfall increased in more polluted experiments. Nevertheless, changes in the rate of precipitation are observed, such that under a polluted atmosphere light rain is increased, while both moderate and heavy rain are weaker, confirming the fact that a decrease in cloud droplet size can reduce precipitations.
The prognostic role of tissue and serum transthyretin expression in patients with surgically resected non-small cell lung cancer
Authors: LI li , Zhong Jian , Zou Jue , Zhang Tiantian , Xu Chunhua 
Published: November 2022

Abstract
Background
Transthyretin (TTR) is a traditional biomarker for nutritional and inflammatory. The present study was conducted to explore the clinical value of TTR in serum and tumor tissue in patients with surgically resected non-small cell lung cancer (NSCLC).
Methods
TTR expression levels were determined in paraffin-embedded NSCLC tissue specimens using immunohistochemistry. Serum TTR expression levels were measured from patients with lung cancer and healthy controls using enzyme-linked immunosorbent assay (ELISA).
Results
The expression levels of TTR were significantly higher in lung cancer tissues than in paracancerous tissues, and TTR expression was significantly associated with TNM stage (P = 0.002) and lymph node metastasis (P = 0.032). Multivariate analysis revealed that increased expression of TTR was an independent risk factor for overall survival (OS) (P = 0.012) and disease-free survival (DFS) (P = 0.011) in NSCLC patients. The expression levels of TTR in serum from lung cancer patients were lower than those of healthy controls (P = 0.002). A high expression of TTR in tumor tissue was associated with a higher serum level (r = 0.799, P = 0.001).
Conclusions
TTR expression is upregulated in lung cancer patients, and its expression was correlated with poor prognosis in NSCLC patients.
Effects of stellate ganglion block on postoperative cognitive dysfunction in elderly patients undergoing radical resection of gastrointestinal malignant tumor
Authors: Yan Shiting , Yu Yanlong , Chen Chao , Xia Wei , Xue Feng , Ma Jianming , Yu Leyang , Wang Ying , Tian Shunping , Zhang Dongsheng , Zhang Zhuan 
Published: November 2022

AbstractPurpose:To investigate the effects of stellate ganglion block (SGB) on postoperative cognition dysfunction (POCD) in elderly patients undergoing radical resection for malignant tumor.Methods:Herein, 40 patients undergoing radical reaction of gastrointestinal malignant tumor were randomly divided into two groups: Group S (preoperative SGB implementation) and Group C (control group). General anesthesia combined with epidural anesthesia was performed in both groups. HR, MAP and SPO2were recorded before general anesthesia induction (T1), immediately after tracheal intubation (T2), at surgery beginning (T3), 1 h after surgery beginning (T4), 2 h after surgery beginning (T5), at the end of surgery (T6), immediately after extubation (T7) and 30 min after transferring into the PACU (T8), respectively. Changes of electrolytes and blood glucose were recorded at T1, T4, T5and T6. Plasma IL-1, IL-6, IL-10 and S100-β concentrations were recorded at 1 day before surgery (T0), 1 day postoperatively (T9) and 3 day postoperatively (T10). Cognitive function was assessed at T0, T9, T10, 5 day postoperatively (T11) and 7 day postoperatively (T12) using the Mini-mental State Examination (MMSE) scale.Results:Compared with Group C, Group S had significantly lower blood glucose levels at T5and T6(P< 0.05), lower IL-6 at T9and S100-β at T9and T10(P< 0.05), lower IL-1 while higher IL-10 at T10(P< 0.05), and higher MMSE scores at T9and T10, with lower incidence of POCD (P< 0.05).Conclusion:SGB improves postoperative cognitive function and decreases the incidence of POCD in elderly patients undergoing radical resection for gastrointestinal malignant tumor.
Bilateral Paramedian Thalamic Infarct without Involvement of Corticospinal Tract
Authors: Hassan Mohamed Sheikh , Sidow Nor Osman 
Published: November 2022

Abstract
Introduction and importance: Bilateral thalamic infarct is a rare form of stroke. Mostly thalamic infarcts are unilateral. Occlusion of the artery of Percheron leads to bilateral thalamic infarction with or without involvement of the midbrain. In most cases, bilateral thalamic infarction leads to cognitive dysfunction, opthalmoparesis, conscious impairment, behavioral disturbance, and corticospinal dysfunction.
Case Presentation: A 75-year-old male patient presented to the emergency department of our hospital with agitation and somnolence for one day. He had poorly controlled hypertension. There was no previous history of stroke, diabetes mellitus, hyperlipidemia, known cardiac disease, or smoking history. There was no seizure, recent headache, or visual disturbance. The patient was somnolent and not oriented to time, person, or place. Neurological examination did not show any focal weakness or vertical eye movement restrictions. Other systemic examinations, including those of the respiratory and cardiovascular systems, were unremarkable. Extensive laboratory investigations excluded potential metabolic, infectious, endocrine, or toxic etiologies. The patient did not have any recent history of drug misuse, including benzodiazepines. Brain MRI with diffusion-weighted imaging showed an acute bilateral thalamic infarct. Cerebral MRI angiography was unremarkable. ECG and echocardiography did not show any potential cardioembolic source. The patient was treated with low molecular weight heparin 60 mg subcutaneously, aspirin 300 mg daily, and haloperidol 5mg twice daily. After two weeks of intrahospital treatment, his condition improved (consciousness and orientation massively improved). He was discharged for outpatient neurology clinic follow up.
Conclusion: Bilateral thalamic infarcts are rare presentations of posterior circulation stroke; conscious impairment, agitation, and cognitive dysfunction are the major presentations. Here we report an interesting case with hypertension diagnosed bilateral thalamic infarction without corticospinal tract involvement.
Can the current monkeypox affect the heart? A Comprehensive Systematic Review
Authors: Sayad Reem , Siddiq Abdelmonem , Hashim Ahmed , Elsaeidy Ahmed Saad 
Published: November 2022

Abstract
Background
Till now all symptoms of monkeypox virus aren’t known, and we still discover new symptoms associated with monkeypox. Accordingly, we aimed to summarize evidence about cardiac complications associated with monkeypox virus.
Methods
On Oct. 27, 2022, a systematic search of the literature was done to locate papers that discuss any cardiac complications associated with monkeypox, then data were analyzed qualtitively.
Results
five articles including seven cases that reported cardiovascular complications of the disease were included in the review, it was reported that five were men of which four are bisexual or gays which reveal the importance of the sexual route in the disease transmission. All of seven cases have different forms of cardiac complications such as acute myocarditis, pericarditis, pericardial effusion and myopericarditis. Most of them have evidence of systemic inflammatory response in the form of fever, myalgia, and headache.
Conclusions
The first study summarizes cardiac complications of monkeypox infection. It indicates the possibility of cardiac complications of monkeypox infection which can be managed by supportive treatment and complete rest for a period that may reach 6 months depending on the status of the patient.
Peripheral Red Blood Cells Morphology in Covid-19 Patients
Authors: Gassoum Alsadig 
Published: November 2022

Abstract
Covid-19 pandemic has resulted in global health disaster and posed a great challenge to the suitable measures to contain the disease. The pathogenesis of the disease is still evolving. In the search for the pathogenesis of the virus, little attention has been made to the peripheral blood picture in Covid-19 patients. This study has focused on the morphology of the red blood cells as stained with Geimsa. The results showed distinct RBCs morphological changes includingrouleauxformation, Significant finding of ring-like stained bodies were seen within the RBCs in 98.3%of the patients. No such ring bodies were detected in any of the control smears. In a number of smears stained particles were seen on the RBCs cell wall. Macrocytosis with central polar stomatocytes and tear shape RBCs were seen. Nuclei of neutrophils with fetus like structure and anisocytosisand mild poikilocytosis were reported The number of reticulocytes and platelets is scanty in the covid-19 patients compared to controls. All patients’ blood smears showed marked lymphocytopenia, thrombocytopenia and slight neutrophilia with nuclei fetus like structure. Direct Coombs test was listed to be positive in 15% of the patients. In conclusion peripheral blood picture seems to be easy and predictable tool to diagnose Covid-19 patients.
Exact solution for certain regular thermoelasticity problems in a rectangular long rod by complex harmonics
Authors: Dhaba A. R. El , Abou-Dina M. S. 
Published: November 2022

Abstract
A simple expansion method is used to solve certain regular, uncoupled plane problems of thermoelastostatics for long rods in a rectangle. These solutions are exact when the involved boundary conditions are in polynomial form. A particular case involving heat source in the bulk and surface distributions of temperature and pressures is considered for an exact solution. The results are plotted and discussed.