bluuebunny/crossref_metadata_2025_split huggingface dataset:
Directional Laser from Solution‐Grown Grating‐Patterned Perovskite Single‐Crystal Microdisks
Authors: Zhang Zemin , Vogelbacher Florian , De Jianbo , Wang Yang , Liao Qing , Tian Yang , Song Yanlin , Li Mingzhu 
Published: June 2022

AbstractSolution‐processed, high‐gain, and wavelength‐tunable perovskite single‐crystal microdisk (PVKsc‐MD) lasers have emerged as prospective coherent light sources in advanced nanophotonic designs. However, the inevitable multi‐directional emission from a highly symmetrical cavity leads to low light collection efficiency which greatly hinders its application in integrated optical circuits. Here, we report on surface‐patterned MAPbBr3 PVKsc‐MDs synthesized by a cost‐efficient bottom‐up solution process employing spin‐coating and confined‐growth nanoimprinting. The patterned microdisks have high crystal quality with regular shape and sharp edges and nano‐grating structure on the upper surface. This straightforward process yields surface‐patterned PVKsc‐MD lasers with a low lasing threshold and high quality (Q) factor. In addition, the grating structure patterned on the PVKsc‐MDs reduces the original symmetry of the laser cavity, which improves the emission directionality four times.
Metal–Organic Frameworks for Ion Conduction
Authors: Xue Wendan , Sewell Christopher D. , Zhou Qixing , Lin Zhiqun 
Published: June 2022

AbstractSolid‐state ionic conductors are compelling alternatives to liquid electrolytes in clean energy‐harvesting and ‐storage technologies. The development of novel ionic conducting materials is one of the most critical challenges for next‐generation energy technologies. Several advancements in design strategies, synthetic approaches, conducting properties, and underlying mechanisms for ionic conducting metal–organic frameworks (MOFs) have been made over the past five years; however, despite the recent, considerable expansion of related research fields, there remains a lack of systematic overviews. Here, an extensive introduction to ionic conducting performance for MOFs with different design strategies is provided, focusing primarily on ion mobility with the aid of hydrogen‐bonding networks or solvated ionic charge. Furthermore, current theories on ion conducting mechanisms in different regimes are comprehensively summarized to provide an understanding of the underlying working principles in complex, realistic systems. Finally, challenges and future research directions at the forefront of ionic conducting MOF technologies are outlined.
Comparative Evaluation of Light‐Driven Catalysis: A Framework for Standardized Reporting of Data**
Authors: Ziegenbalg Dirk , Pannwitz Andrea , Rau Sven , Dietzek‐Ivanšić Benjamin , Streb Carsten 
Published: June 2022

AbstractLight‐driven homogeneous and heterogeneous catalysis require a complex interplay between light absorption, charge separation, charge transfer, and catalytic turnover. Optical and irradiation parameters as well as reaction engineering aspects play major roles in controlling catalytic performance. This multitude of factors makes it difficult to objectively compare light‐driven catalysts and provide an unbiased performance assessment. This Scientific Perspective highlights the importance of collecting and reporting experimental data in homogeneous and heterogeneous light‐driven catalysis. A critical analysis of the benefits and limitations of the commonly used experimental indicators is provided. Data collection and reporting according to FAIR principles is discussed in the context of future automated data analysis. The authors propose a minimum dataset as a basis for unified collecting and reporting of experimental data in homogeneous and heterogeneous light‐driven catalysis. The community is encouraged to support the future development of this parameter list through an open online repository.
2D MOF with Compact Catalytic Sites for the One‐pot Synthesis of 2,5‐Dimethylfuran from Saccharides via Tandem Catalysis
Authors: Deng Qiang , Hou Xuemeng , Zhong Yao , Zhu Jiawei , Wang Jun , Cai Jianxin , Zeng Zheling , Zou Ji‐Jun , Deng Shuguang , Yoskamtorn Tatchamapan , Tsang Shik Chi Edman 
Published: June 2022

AbstractOne pot synthesis of 2,5‐dimethylfuran (2,5‐DMF) from saccharides under mild conditions is of importance for the production of biofuel and fine chemicals. However, the synthesis requires a multitude of active sites and suffers from slow kinetics due to poor diffusion in most composite catalysts. Herein, a metal‐acid functionalized 2D metal‐organic framework (MOF; Pd/NUS‐SO3H), as an ultrathin nanosheet of 3–4 nm with Lewis acid, Brønsted acid, and metal active sites, was prepared based on the diazo method for acid modification and subsequent metal loading. This new composite catalyst gives substantially higher yields of DMF than all reported catalysts for different saccharides (fructose, glucose, cellobiose, sucrose, and inulins). Characterization suggests that a cascade of reactions including polysaccharide hydrolysis, isomerization, dehydration, and hydrodeoxygenation takes place with rapid molecular interactions.
Enantioselective Synthesis of Enantioisotopomers with Quantitative Chiral Analysis by Chiral Tag Rotational Spectroscopy
Authors: Mills Mitchell D. , Sonstrom Reilly E. , Vang Zoua Pa , Neill Justin L. , Scolati Haley N. , West Channing T. , Pate Brooks H. , Clark Joseph R. 
Published: June 2022

AbstractFundamental to the synthesis of enantioenriched chiral molecules is the ability to assign absolute configuration at each stereogenic center, and to determine the enantiomeric excess for each compound. While determination of enantiomeric excess and absolute configuration is often considered routine in many facets of asymmetric synthesis, the same determinations for enantioisotopomers remains a formidable challenge. Here, we report the first highly enantioselective metal‐catalyzed synthesis of enantioisotopomers that are chiral by virtue of deuterium substitution along with the first general spectroscopic technique for assignment of the absolute configuration and quantitative determination of the enantiomeric excess of isotopically chiral molecules. Chiral tag rotational spectroscopy uses noncovalent chiral derivatization, which eliminates the possibility of racemization during derivatization, to perform the chiral analysis without the need of reference samples of the enantioisotopomer.
Lower neutrophil‐to‐lymphocyte ratio and positive programmed cell death ligand‐1 expression are favorable prognostic markers in patients treated with pembrolizumab for urothelial carcinoma
Authors: Miyama Yu , Kaneko Go , Nishimoto Koshiro , Yasuda Masanori 
Published: June 2022

AbstractBackgroundImmune checkpoint inhibitors (ICIs) are effective in some cancer patients; however, they may show no efficacy in others. Predictive biomarkers are crucial for appropriately selecting the patients who receive ICI therapy. This study aimed to clarify the predictors of disease progression in urothelial carcinoma (UC) patients treated with an ICI, pembrolizumab.MethodsWe analyzed the response patterns of 50 UC patients who were treated with pembrolizumab, as well as the association between survival and clinicopathological factors. Clinical factors included age, sex, body mass index, clinical courses, laboratory data, metastases, and adverse events. Pathological factors included special variant, squamous differentiation, programmed cell death ligand‐1 (PD‐L1) expression, CD8‐positive lymphocytes density, and CDKN2A/p16 homozygous deletion.ResultsDuring pembrolizumab treatment, four (8%), 11 (22%), and eight (16%) patients achieved the best‐case scenarios of complete response, partial response, and stable disease, respectively. Twenty‐seven patients (54%) showed progressive disease. In this study, younger age, lower preoperative neutrophil‐to‐lymphocyte ratio (NLR), and positive PD‐L1 expression were significantly correlated with longer progression‐free survival and overall survival. Moreover, lower NLR and positive PD‐L1 expression were independently associated with longer OS in multivariate analysis.ConclusionsBased on our observations, lower NLR and positive PD‐L1 expression may be independent favorable prognostic markers in UC patients treated with pembrolizumab. These results suggest that both host and tumor status can reflect the effectiveness of pembrolizumab among patients with UC.
Interactive exploration of drapes by simulation parameters
Authors: Ju Eunjung , Kim Kwang‐yun , Lee Jaehoon , Yoon Sungjin , Choi Myung Geol 
Published: June 2022

AbstractHow similar a virtual product is to a real product is one of the most important issues when using virtual simulation to develop real apparel designs. The first step to achieve high similarity is finding optimal simulation parameters for the desired fabrics. However, it is notoriously difficult to find an optimal parameter set that reproduces the physical properties of a specific fabric as closely as possible. It is because the relationship between the changes of simulation parameters and drape shapes is highly non‐linear, not intuitive, and hard to be predicted even by experts. Therefore, users have to repeat trial and error based on personal experience until they find satisfactory results, which is time consuming due to the simulation time required for each trial. To handle this problem, we proposed a neural network model that learns the relationship between the parameter space and the drape space, then we presented a user interface that allows users to quickly explore the extensive drape space through simulation parameters. To validate our method, we provided our UI with experts in the fashion design industry and conducted user studies with them for qualitative evaluation.
Cyclic Disulfide Liposomes for Membrane Functionalization and Cellular Delivery
Authors: Qualls Megan L. , Lou Jinchao , McBee Dillon P. , Baccile Joshua A. , Best Michael D. 
Published: June 2022

AbstractLiposomes are effective therapeutic delivery nanocarriers due to their ability to encapsulate and enhance the pharmacokinetic properties of a wide range of therapeutics. Two primary areas in which improvement is needed for liposomal drug delivery is to enhance the ability to infiltrate cells and to facilitate derivatization of the liposome surface. Herein, we report a liposome platform incorporating a cyclic disulfide lipid (CDL) for the dual purpose of enhancing cell entry and functionalizing the liposome membrane through thiol‐disulfide exchange. In order to accomplish this, CDL‐1 and CDL‐2, composed of lipoic acid (LA) or asparagusic acid (AA) appended to a lipid scaffold, were designed and synthesized. A fluorescence‐based microplate immobilization assay was implemented to show that these compounds enable convenient membrane decoration through reaction with thiol‐functionalized small molecules. Additionally, fluorescence microscopy experiments indicated dramatic enhancements in cellular delivery when CDLs were incorporated within liposomes. These results demonstrate that multifunctional CDLs serve as an exciting liposome system for surface decoration and enhanced cellular delivery.
Intramolecular, Interrupted Homo‐Nazarov Cascade Biscyclizations to Angular (Hetero)Aryl‐Fused Polycycles
Authors: Chen Doris , Jones Elizabeth V. , Williams Corey W. , Huynh Tan‐Khang N. , McPhail Tristan C. , France Stefan 
Published: June 2022

AbstractHerein, a SnCl4‐catalyzed intramolecular, interrupted homo‐Nazarov cascade biscyclization to access angular (hetero)aryl‐fused polycycles is reported. Subsequent decarboxylation of the readily enolizable products afforded the angular products in up to 71 % yield over two steps, with the trans‐diastereomers as the major products. The cyclopropyl homo‐Nazarov cyclization precursors were formed using a scalable and modular synthetic route that, ultimately, offers access to 6,6,6‐, 6,6,5‐, 6,5,6‐, 6,6,5,6‐, and 6,6,6,5‐fused angular polycyclic products. To showcase the rigor and utility of the method, an 8‐step total synthesis of (±)‐1‐oxoferruginol, an antibacterial aromatic abietane diterpenoid, was disclosed.
Altered innate immune profile in blood of systemic mastocytosis patients
Authors: Pérez‐Pons Alba , Jara‐Acevedo María , Henriques Ana , Navarro‐Navarro Paula , García‐Montero Andrés C. , Álvarez‐Twose Iván , Pedreira Carlos E. , Sánchez‐Muñoz Laura , Damasceno Daniela , Caldas Carolina , Muñoz‐González Javier I. , Matito Almudena , Flores‐Montero Juan , González‐López Oscar , Criado Ignacio , Mayado Andrea , Orfao Alberto 
Published: June 2022

AbstractBackgroundMast cells (MC) from systemic mastocytosis (SM) patients release MC mediators that lead to an altered microenvironment with potential consequences on innate immune cells, such as monocytes and dendritic cells (DC). Here we investigated the distribution and functional behaviour of different populations of blood monocytes and DC among distinct diagnostic subtypes of SM.MethodsOverall, we studied 115 SM patients ‐ 45 bone marrow mastocytosis (BMM), 61 indolent SM (ISM), 9 aggressive SM (ASM)‐ and 32 healthy donors (HD). Spontaneous and in vitro‐stimulated cytokine production by blood monocytes, and their plasma levels, together with the distribution of different subsets of blood monocytes and DCs, were investigated.ResultsSM patients showed increased plasma levels and spontaneous production by blood monocytes of IL1β, IL6, IL8, TNFα and IL10, associated with an exhausted ability of LPS + IFNγ‐stimulated blood monocytes to produce IL1β and TGFβ. SM (particularly ISM) patients also showed decreased counts of total monocytes, at the expense of intermediate monocytes and non‐classical monocytes. Interestingly, while ISM and ASM patients had decreased numbers of plasmacytoid DC and myeloid DC (and their major subsets) in blood, an expansion of AXL+ DC was specifically encountered in BMM cases.ConclusionThese results demonstrate an altered distribution of blood monocytes and DC subsets in SM associated with constitutive activation of functionally impaired blood monocytes and increased plasma levels of a wide variety of inflammatory cytokines, reflecting broad activation of the innate immune response in mastocytosis.
Patient navigation to address sociolegal barriers for patients with cancer: A comparative‐effectiveness study
Authors: Battaglia Tracy A. , Gunn Christine M. , Bak Sharon M. , Flacks JoHanna , Nelson Kerrie P. , Wang Na , Ko Naomi Y. , Morton Samantha J. 
Published: June 2022

BackgroundSociolegal barriers to cancer care are defined as health‐related social needs like affordable healthy housing, stable utility service, and food security that may be remedied by public policy, law, regulation, or programming. Legal support has not been studied in cancer care.MethodsThe authors conducted a randomized controlled trial of patients who had newly diagnosed cancer at a safety‐net medical center in Boston from 2014 through 2017, comparing standard patient navigation versus enhanced navigation partnered with legal advocates to identify and address sociolegal barriers. English‐speaking, Spanish‐speaking, or Haitian Creole‐speaking patients with breast and lung cancer were eligible within 30 days of diagnosis. The primary outcome was timely treatment within 90 days of diagnosis. Secondary outcomes included patient‐reported outcomes (distress, cancer‐related needs, and satisfaction with navigation) at baseline and at 6 months.ResultsIn total, 201 patients with breast cancer and 19 with lung cancer enrolled (response rate, 78%). The mean patient age was 55 years, 51% of patients were Black and 22% were Hispanic, 20% spoke Spanish and 8% spoke Haitian Creole, 73% had public health insurance, 77% reported 1 or more perceived sociolegal barrier, and the most common were barriers to housing and employment. Ninety‐six percent of participants with breast cancer and 73% of those with lung cancer initiated treatment within 90 days. No significant effect of enhanced navigation was observed on the receipt of timely treatment among participants with breast cancer (odds ratio, 0.88; 95% CI, 0.17‐4.52) or among those with lung cancer (odds ratio, 4.00; 95% CI, 0.35‐45.4). No differences in patient‐reported outcomes were observed between treatment groups.ConclusionsNavigation enhanced by access to legal consultation and support had no impact on timely treatment, patient distress, or patient needs. Although most patients reported sociolegal barriers, few required intensive legal services that could not be addressed by navigators.Lay Summary

In patients with cancer, the experience of sociolegal barriers to care, such as unstable housing, utility services, or food insecurity, is discussed. Addressing these barriers through legal information and assistance may improve care.
This study compares standard patient navigation versus enhanced navigation partnered with legal advocates for patients with breast and lung cancers. Almost all patients in both navigation groups received timely care and also reported the same levels of distress, needs, and satisfaction with navigation.
Although 75% of patients in the study had at least 1 sociolegal barrier identified, few required legal advocacy beyond what a navigator who received legal information and coaching could provide.
Myoinhibitory peptides in the central complex of the locust Schistocerca gregaria and colocalization with locustatachykinin‐related peptides
Authors: Hensgen Ronja , Dippel Stefan , Hümmert Sophie , Jahn Stefanie , Seyfarth Jutta , Homberg Uwe 
Published: June 2022

AbstractThe central complex in the brain of insects provides a neural network for sensorimotor processing that is essential for spatial navigation and locomotion and plays a role in sleep control. Studies on the neurochemical architecture of the central complex have been performed especially in the fruit fly Drosophila melangoaster and the desert locust, Schistocerca gregaria. In several insect species, myoinhibitory peptides (MIPs) are involved in circadian control and sleep‐wake regulation. To identify neurons that might underlie these functions, we investigated the distribution of MIPs in the central complex of the locust. In silico transcript analysis suggests the presence of eight different MIPs in the desert locust. Through immunolabeling, we identified five systems of central‐complex neurons that express MIP‐like peptides. Two systems constitute columnar neurons of the protocerebral bridge and the lower division of the central body, while the other three systems are columnar neurons (two systems) and tangential neurons (one system) of the upper division of the central body. The innervation pattern and cell count of two systems of columnar neurons revealed the existence of 18 instead of 16 columns of the protocerebral bridge. Immunostaining of preparations containing intracellularly stained single cells allowed us to further specify subtypes of labeled columnar neurons. Double‐label experiments showed that three systems of MIP‐immunostained columnar neurons are also locustatachykinin‐immunoreactive. No colocalization was found with serotonin immunostaining. The data provide novel insights into the architecture of the locust central complex and suggest that MIPs play a prominent role within the central‐complex network.
Calcitonin gene‐related peptide: An intra‐articular therapeutic target for TMJ disorders
Authors: Brouxhon Sabine M. , O'Banion M. Kerry , Dickerson Ian M. , Kyrkanides Stephanos 
Published: June 2022

AbstractObjectivesThe goal of this project was to evaluate the role of calcitonin gene‐related peptide (CGRP) in the development of arthritis.MethodsHerein, we employed somatic mosaic analysis in two different joints by FIV(CGRP) intra‐articular inoculation in the knees or temporomandibular joints (TMJ) of young adult male C57/BL6 mice. FIV(CGRP) is a feline immunodeficiency virus over‐expressing full‐length CGRP. Joint pathology and function were evaluated at the histopathological and behavioral levels. In addition, CGRP signaling was inhibited by intra‐articular inoculation using FIV(CGRP8‐37), such that the inhibitory peptide CGRP(8‐37) was overexpressed 4 weeks after induction of joint inflammation in the TMJ of IL‐1βXAT transgenic mouse model. The mice were evaluated for behavior and killed for evaluation of knee and TMJ pathology.ResultsOverexpression of CGRP in the joints of wild‐type mice induced the development of joint anomalies, including meniscal hypertrophy and articular pathology, associated with nocifensive behavior. Intriguingly, overexpression of the CGRP(8‐37) inhibitory peptide in the knee and TMJ of IL‐1βXAT transgenic mice with joint inflammation resulted in partial amelioration of the attendant joint pathology.ConclusionsThe results of this study suggest that CGRP is sufficient and necessary for the development of joint pathology and may serve as an intra‐articular therapeutic target using gene therapy or monoclonal antibody‐based therapies.
A fully integrated soft switched high frequency resonant DC‐DC voltage regulator
Authors: Meshkat Amin , Dehghani Rasoul , Farzanehfard Hosein 
Published: June 2022

SummaryFully integrated 750‐MHz resonant voltage regulator is presented. Providing soft switching conditions for the transistors has prevented degradation of the converter efficiency at this high switching frequency. High switching frequency has reduced volume of the passive on‐chip components and thus increased the converter current density. Due to the limitations of the CMOS processes, control and gate drive circuits are designed to increase chip reliability. One of the major challenges of the fully integrated voltage regulators is the on‐chip inductor realization. Based on the mathematical models for inductance and resistance of spiral on‐chip inductor, the geometric dimensions of the employed inductor are optimally designed to have maximum quality factor and minimum chip area. The power switches are optimized to achieve maximum efficiency. All post layout parasitic elements of MOSFETs and metal routings including inductive effects are extracted using 3‐D EM simulation and finite element method for 0.18‐
m standard CMOS technology. Maximum output voltage ripple is 5.2% at maximum load current. Peak efficiency of the proposed on‐chip power supply is 82% when input/output voltage is 1.8 V/1.48 V and load current is 120 mA. Maximum value of the efficiency enhancement factor is 42% for output input/voltage of 1.8 V/0.55 V. Current density of the proposed converter is 574 mA/mm2. In the worst case, the load step causes an overvoltage/undervoltage smaller than 15.56% at the output voltage.
NIS‐Mediated Intramolecular sp3 C−H Oxidation of 2‐Alkyl‐Substituted Benzamides**
Authors: Sun Lei , Cui Jichun , Nie Shaozhen , Xie Lei , Wang Yanlan , Wu Lingang 
Published: June 2022

AbstractIn this work, we describe the N‐iodosuccinimide‐mediated benzyl sp3 C−H oxidation of 2‐alkyl‐substituted benzamide derivatives. This Hofmann‐Löffler‐Freytag (HLF) type reaction involving intramolecular sp3 C−O bond formation differs from the construction of the C−N bond in the classic and modified HLF reactions. This reaction proceeded smoothly via 1,5‐hydrogen atom transfer of N‐centered radicals directly afforded by in situ N−I bond generation, providing iminoisobenzofuran derivatives in moderate to excellent yields with exclusive chemoselectivity.