bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between freshwater harmful algal blooms and neurodegenerative disease incidence rates in South Korea
Authors: Lee Seungjun , Choi Boseung , Kim Sung Jae , Kim Jinnam , Kang Dayun , Lee Jiyoung 
Published: November 2022

Abstract
Background
Due to anthropogenic activities and global warming, the severity and distribution of harmful algal blooms (HABs) have been increasing steadily worldwide, including in South Korea (S. Korea). Previous studies reported that exposure to HABs could increase the risk of HAB-related diseases. However, very few studies examined the linkage between HABs and disease occurrence, particularly in S. Korea. The objective of this study was to evaluate the potential impact of HABs on neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, and motor neuron disease, at a population level.

Methods
Thirteen-year data (2005–2017) for chlorophyll-a (chl-a) concentrations as a bloom-related parameter, annual numbers of NDs, and population information were collected. First, the entire area of S. Korea was divided into a grid of 1 km, and the population number in each 1-km grid was collected using the Statistical Geographic Information Service Plus system. Cross-sectional time series data were analyzed with two statistical models, a generalized linear mixed model and a generalized linear model.

Results
The results show a general trend of increasing chl-a concentration and NDs year by year. We observed positive correlations between HAB intensity and the incidence rate of NDs. Particularly, HABs seem to have the most long-term carry-over effect on Parkinson’s disease. Another key finding was that a 5-km radius from the HAB location was the boundary that showed the most significant associations with three NDs.

Conclusions
This study provides statistical evidence that supports the potential risk of NDs from the exposure to HAB. Thus, it is recommended to monitor a broad spectrum of cyanotoxins, including neurotoxins, in bloom-affected regions in S. Korea and epidemiological studies in the future.
Reduced left atrial contractile strain with speckle tracking analysis predicts abnormal plasma NTproBNP in an asymptomatic community population
Authors: Liu Lin , Zhang Baowei , Yang Ying , Qi Litong , Wang Shuo , Meng Lei , Ma Wei , Huo Yong 
Published: November 2022

Abstract
Background
The left atrium (LA) is closely related to left ventricular diastolic function. Two-dimensional speckle tracking strain and strain rate (SR) imaging has been applied in the study of LA function. We intended to explore the relationship between global LA deformation parameters and plasma NTproBNP levels in asymptomatic community residents with normal ejection fraction and normal LA volume.

Methods
A cross-sectional sample of Beijing residents underwent comprehensive Doppler echocardiography and medical record review in 2009. Global LA longitudinal strain and SR indexes were obtained in the apical four-chamber view. LA stiffness index (LASI) was calculated as the ratio of early diastolic velocity of transmitral flow/early diastolic mitral annular motion velocity (E/E') to LA reservoir strain.

Results
A total of 620 individuals (mean age = 65.8 years, left ventricular ejection fraction = 70.8%, LA volume index = 17.9 ml/m2) were investigated in our study. 117 individuals had increased plasma NTproBNP (≥ 125 pg/ml). LA reservoir and contractile function by LA strain and SR indexes were significantly reduced in the abnormal NTproBNP group compared with the normal NTproBNP group. Multiple regression analysis indicated that LA contractile strain was a negative predictor of plasma NTproBNP in addition to indexed LA volume and E/E'. LASI was higher in the abnormal NTproBNP group and was significantly correlated with NTproBNP (r = 0.342, P < 0.001). The area under ROC analysis for LASI in predicting elevated plasma NTproBNP was 0.690, similar with LA contractile strain, E/E’ and LAVI. The cut-off value of LASI was 0.612.

Conclusions
LA reservoir and contractile functions demonstrated by LA strain and SR were significantly impaired in the community-based population with increased plasma NTproBNP levels. LA contractile strain adds incremental information in predicting abnormal NTproBNP levels. As a single index, LASI showed similar diagnostic value with LAVI and E/E’ in predicting abnormal NTproBNP.
Is there a role for lung surgery in initially unresectable non-small cell lung cancer after tyrosine kinase inhibitor treatment?
Authors: Diong Nguk Chai , Liu Chia-Chuan , Shih Chih-Shiun , Wu Mau-Ching , Huang Chun-Jen , Hung Chen-Fang 
Published: November 2022

Abstract
Background
The role of lung surgery in initially unresectable non-small cell lung cancer (NSCLC) after tyrosine kinase inhibitor (TKI) treatment remains unclear. We aimed to assess the survival benefits of patients who underwent surgery for regressed or regrown tumors after receiving TKI treatment.

Methods
The details of patients diagnosed with unresectable NSCLC treated with TKI followed by lung resection from 2010 to 2020 were retrieved from our database. The primary endpoint was 3-year overall survival (OS), whereas the secondary endpoints were a 2-year progression-free survival (PFS), feasibility, and the safety of pulmonary resection. The statistical tests used were Fisher’s exact test, Kruskal Wallis test, Kaplan-Meier method, Cox proportional hazards model, and Firth correction.

Results
Nineteen out of thirty-two patients were selected for the study. The patients underwent lung surgery after confirmed tumor regression (17 [89.5%]) and regrowth (two [10.5%]). All surgeries were performed via video-assisted thoracoscopic surgery: 14 (73.7%) lobectomies and five (26.3%) sublobar resections after a median duration of 5 months of TKI. Two (10.5%) postoperative complications and no 30-day postoperative mortality were observed. The median postoperative follow-up was 22 months.
The 2-year PFS and 3-year OS rates were 43.9% and 61.5%, respectively. Patients who underwent surgery for regressed disease showed a significantly better OS than for regrowth disease (HR=0.086, 95% CI 0.008–0.957, p=0.046). TKI-adjuvant demonstrated a better PFS than non-TKI adjuvant (HR=0.146, 95% CI 0.027–0.782, p=0.025).

Conclusion
Lung surgery after TKI treatment is feasible and safe and prolongs survival via local control and directed consequential therapy. Lung surgery should be adopted in multimodality therapy for initially unresectable NSCLC.
Colonocyte-derived lactate promotes E. coli fitness in the context of inflammation-associated gut microbiota dysbiosis
Authors: Taylor Savannah J. , Winter Maria G. , Gillis Caroline C. , Silva Laice Alves da , Dobbins Amanda L. , Muramatsu Matthew K. , Jimenez Angel G. , Chanin Rachael B. , Spiga Luisella , Llano Ernesto M. , Rojas Vivian K. , Kim Jiwoong , Santos Renato L. , Zhu Wenhan , Winter Sebastian E. 
Published: November 2022

Abstract
Background
Intestinal inflammation disrupts the microbiota composition leading to an expansion of Enterobacteriaceae family members (dysbiosis). Associated with this shift in microbiota composition is a profound change in the metabolic landscape of the intestine. It is unclear how changes in metabolite availability during gut inflammation impact microbial and host physiology.

Results
We investigated microbial and host lactate metabolism in murine models of infectious and non-infectious colitis. During inflammation-associated dysbiosis, lactate levels in the gut lumen increased. The disease-associated spike in lactate availability was significantly reduced in mice lacking the lactate dehydrogenase A subunit in intestinal epithelial cells. Commensal E. coli and pathogenic Salmonella, representative Enterobacteriaceae family members, utilized lactate via the respiratory L-lactate dehydrogenase LldD to increase fitness. Furthermore, mice lacking the lactate dehydrogenase A subunit in intestinal epithelial cells exhibited lower levels of inflammation in a model of non-infectious colitis.

Conclusions
The release of lactate by intestinal epithelial cells during gut inflammation impacts the metabolism of gut-associated microbial communities. These findings suggest that during intestinal inflammation and dysbiosis, changes in metabolite availability can perpetuate colitis-associated disturbances of microbiota composition.
Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip
Authors: Mahajan Gautam , Doherty Erin , To Tania , Sutherland Arlene , Grant Jennifer , Junaid Abidemi , Gulati Aakanksha , LoGrande Nina , Izadifar Zohreh , Timilsina Sanjay Sharma , Horváth Viktor , Plebani Roberto , France Michael , Hood-Pishchany Indriati , Rakoff-Nahoum Seth , Kwon Douglas S. , Goyal Girija , Prantil-Baun Rachelle , Ravel Jacques , Ingber Donald E. 
Published: November 2022

Abstract
Background
A dominance of non-iners Lactobacillus species in the vaginal microbiome is optimal and strongly associated with gynecological and obstetric health, while the presence of diverse obligate or facultative anaerobic bacteria and a paucity in Lactobacillus species, similar to communities found in bacterial vaginosis (BV), is considered non-optimal and associated with adverse health outcomes. Various therapeutic strategies are being explored to modulate the composition of the vaginal microbiome; however, there is no human model that faithfully reproduces the vaginal epithelial microenvironment for preclinical validation of potential therapeutics or testing hypotheses about vaginal epithelium-microbiome interactions.

Results
Here, we describe an organ-on-a-chip (organ chip) microfluidic culture model of the human vaginal mucosa (vagina chip) that is lined by hormone-sensitive, primary vaginal epithelium interfaced with underlying stromal fibroblasts, which sustains a low physiological oxygen concentration in the epithelial lumen. We show that the Vagina Chip can be used to assess colonization by optimal L. crispatus consortia as well as non-optimal Gardnerella vaginalis-containing consortia, and to measure associated host innate immune responses. Co-culture and growth of the L. crispatus consortia on-chip was accompanied by maintenance of epithelial cell viability, accumulation of D- and L-lactic acid, maintenance of a physiologically relevant low pH, and down regulation of proinflammatory cytokines. In contrast, co-culture of G. vaginalis-containing consortia in the vagina chip resulted in epithelial cell injury, a rise in pH, and upregulation of proinflammatory cytokines.

Conclusion
This study demonstrates the potential of applying human organ chip technology to create a preclinical model of the human vaginal mucosa that can be used to better understand interactions between the vaginal microbiome and host tissues, as well as to evaluate the safety and efficacy of live biotherapeutics products.
CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin
Authors: Ma Jingbo , Xu Xiaolong , Fu Chunjin , Xia Peng , Tian Ming , Zheng Liuhai , Chen Kun , Liu Xiaolian , Li Yilei , Yu Le , Zhu Qinchang , Yu Yangyang , Fan Rongrong , Jiang Haibo , Li Zhifen , Yang Chuanbin , Xu Chengchao , Long Ying , Wang Jigang , Li Zhijie 
Published: November 2022

Abstract

Background
It is highly desirable to develop new therapeutic strategies for gastric cancer given the low survival rate despite improvement in the past decades. Cadherin 17 (CDH17) is a membrane protein highly expressed in cancers of digestive system. Nanobody represents a novel antibody format for cancer targeted imaging and drug delivery. Nanobody targeting CHD17 as an imaging probe and a delivery vehicle of toxin remains to be explored for its theragnostic potential in gastric cancer.

Methods
Naïve nanobody phage library was screened against CDH17 Domain 1-3 and identified nanobodies were extensively characterized with various assays. Nanobodies labeled with imaging probe were tested in vitro and in vivo for gastric cancer detection. A CDH17 Nanobody fused with toxin PE38 was evaluated for gastric cancer inhibition in vitro and in vivo.

Results
Two nanobodies (A1 and E8) against human CDH17 with high affinity and high specificity were successfully obtained. These nanobodies could specifically bind to CDH17 protein and CDH17-positive gastric cancer cells. E8 nanobody as a lead was extensively determined for tumor imaging and drug delivery. It could efficiently co-localize with CDH17-positive gastric cancer cells in zebrafish embryos and rapidly visualize the tumor mass in mice within 3 h when conjugated with imaging dyes. E8 nanobody fused with toxin PE38 showed excellent anti-tumor effect and remarkably improved the mice survival in cell-derived (CDX) and patient-derived xenograft (PDX) models. The immunotoxin also enhanced the anti-tumor effect of clinical drug 5-Fluorouracil.

Conclusions
The study presents a novel imaging and drug delivery strategy by targeting CDH17. CDH17 nanobody-based immunotoxin is potentially a promising therapeutic modality for clinical translation against gastric cancer.

Graphical Abstract
Economic Ecosystems and Postcapitalist Futures in The Professor's House
Authors: Kimmet Sarah 
Published: November 2022

Abstract
Despite Willa Cather's claims about the incompatibility of art and economics, the majority of her novels are structured by and around economic ecosystems, both capitalist and noncapitalist. This article argues that Cather's sensitivity to the heterogeneity of the American economic landscape allows her to explore sites of anti-capitalist resistance that are often dismissed by traditional Marxists (and postmodern liberals) still wedded to a rigid Hegelian dialectic. Anticipating the insights of analytical Marxists and network theorists as well as the historical trajectory of late capitalism, The Professor's House explores the possibilities of eroding capitalism from within by leveraging the concrete alternatives that already exist within and adjacent to it. Neither capitalist breakdown nor proletariat revolution appear on the horizon of the world Cather's protagonists inhabit; nevertheless, possibilities for potentially revolutionary collective action still exist.
Does a gluten-free diet affect the course of Hashimoto's disease? - the review of the literature
Authors: Krzysiek Urszula , Podgórska Klaudia , Puła Aleksandra , Artykiewicz Klaudia , Urbaś Weronika , Grodkiewicz Maria , Kozieł Paweł , Czarkowski Marcin , Gorczyca Kamila , Słupczyńska Aleksandra 
Published: November 2022

Introduction and purpose
The fashion for following a gluten-free diet is causing more and more people to opt for it. It is indicated in the treatment of celiac disease. Due to the high prevalence of Hashimoto's disease in the population and the lack of causal treatment for the disease, many researchers have tested the validity of gluten elimination for those burdened with it. This work aimed to review the results achieved so far and assess whether this diet has a real impact on the course of Hashimoto's disease.
A brief description of the state of knowledge
A PubMed database was searched for studies describing the relationship between gluten consumption and the course of Hashimoto's disease. Some studies indicated a potential beneficial effect of the introduced diet on thyroid function. However, these were mostly survey-based studies of questionable research quality. More reliable studies that took into account antibody and TSH levels showed no significant improvement in thyroid function in response to the diet.
Conclusions
Based on the studies reviewed, there is no need for a gluten-free diet in patients with chronic autoimmune thyroid disease. It has not been proven that gluten can provoke the body to produce autoantibodies that cause the destruction of thyroid tissue. It is more important to maintain a balanced diet rich in zinc, selenium, iodine, vitamin D3, and iron, as they are essential in the process of hormone production by the thyroid gland.
Footballers' endurance based on Berlin football teams
Authors: Kalinowski Paweł , Kalinowska Katarzyna , Jerszyński Damian , Rachwalski Krzysztof , Pietranis Dariusz 
Published: November 2022

Endurance is one of the most essential motor skills in the well planned training process in football. The high intensity and pace of the game force the players to be very well prepared. The increasing requirements of the game over the years direct the attention towards the oxygen mechanisms of football players.The aim of the study was to determine a relationship between the endurance tested by the Cooper test and the effectiveness of the game, determined by a modified method of competent referees.The study was inclued 90 footballers of german clubs SV Berliner Brauereien, Berliner TSC and BSC Eintracht Südring Berlin. The results of studies conducted in Berlin in 2015-2018 were analysed.Descriptive statictics were conducted: mean (X), minimum values (min), maximum values (max) and standard deviation (SD). Normal distribution was checked and correlation coefficient were determined. The results of the study were statistically analyzed in Statistica 13,3.In the study on a bigger number of players, a statistically significant relationship was noted between the effectiveness of the game of German team players and cardio-respiratory endurance.
Muscle dysfunction during physical activity – muscle rhabdomyolysis
Authors: Żołądkiewicz Katarzyna , Pabianek Łukasz , Jaśkiewicz Łukasz , Brzezińska Paulina 
Published: November 2022

Rhabdomyolysis is the breakdown of striated muscle fibers, which results in the release of muscle cell components into the peripheral circulation. Most cases of rhabdomyolysis are the result of trauma, often a consequence of seizures, alcohol and drug abuse but in some cases it is associated with very intensive physical activity. Proper understanding of muscle rhabdomyolysis can contribute to better preparation of sportsman for the intensive physical activity and to protect his body from episodes of extensive muscle breakdown and prevent their occurrence. This article is an attempted to summarize and show medical and biochemical basics of muscle rhabdomyolysis with a special attention to the episodes that occurs during physical activity. It may help in prevention of such cases in the future and protects the body of a sportsmen.
Fundamental Motor Skills in Identifying Differences in Performance level between Students and Athletes Ages 10-12 years
Authors: Elmazi Rovena , Miftari Florian 
Published: November 2022

Fundamental motor skills that are developed during childhood are considered to be the building blocks for sport-specific movement patterns and are typically the focus of physical development programs for children, to develop gross motor skills from early childhood. Specifically, it has been shown that within a sport-specific environment, fundamental motor skills can separate children with potential for sport success. This is because gross motor skills underpin the development of the more specific sport skills that will likely be required for future sport success.The study aimed to assess fundamental motor skills in identifying differences in performance levels between students and athletes aged 10-12 years living in Albania, and further examine the indicators obtained in order to study how these two groups of children compare to each other. The data gathered through this study are indispensable in revealing the level of obesity, physical and technical capacities and identifying talented athletes. 641 students coming from the primary and secondary school systems and 410 athletes were subjected to standard anthropometric measurements (weight/height/BMI), standard physical fitness tests (push-up, abdominal press high jump, long jump, horizontal stretch, 30m dash, shuttle run 112 m) and technical measurements (Bridling, passing boll, Moving in defence and shooting) Based on BMI standards for students and athletes of this age group, it can be observed that athletes demonstrate a growth in body mass, even the physical fitness and technical indicators tested speak for a bigger development of athletes . Therefore, testing procedures should be expanded from only subjective measures of players’ abilities and objective tests of specific conditioning capacities to the objective assessments of technical capacities connected to the motor skills of individuals. This could then be used to select children at an age when the goal is to identify those talented in basketball.
A game without penalty: Purchasing a professional club, a rational crime?
Authors: Carin Yann , Terrien Mickael 
Published: November 2022

This paper aims to advance a new strategic explanation for the detention of a professional football club based on criminal motivations. Despite recurring deficits, most of the French professional football teams have changed owner over the last years (22 of 40 since 2010). It is therefore difficult at first sight to understand why investors are attracted to this industry. Beyond the internal / external distinction, this article advances a new explanation based on economics of crime. Semi-structured interviews were performed and primary data was analyzed to explain that purchasing a professional football club for criminal ends would be rational. The removal of the Third Party Ownership may explain some of this phenomenon. Results also suggest that the football industry is a criminogenic market. From this, it was possible to derive consequences of the potential criminal behavior of the new investors and managerial recommendations to fight against this existing situation.
Sports indicators affecting the brand
Authors: Kiani Mohammad Saeid , Nazari Leila 
Published: November 2022

Objective: The purpose of this study was to present a model of sport indicators affecting the brand of the country.
Methodology: This is a correlational study and the statistical population of this study is PhD students in sports in Iran (N = 400). Based on Morgan's table, 144 Individuals were selected by random method. In order to achieve the research goals, a comprehensive list of sports indicators was prepared and adjusted and a researcher - made questionnaire was developed. The validity of the questionnaire was confirmed by 15 sports management professors and their reliability was in a preliminary study with 30 subjects and Cronbach's alpha was calculated to be 0.909 . Descriptive and inferential statistical methods such as exploratory factor analysis, and confirmatory factor analysis were used to analyze the data using SPSS and LISREL software.
Results: The results showed that the main variables have eight general dimensions of sport tourism, sport diplomacy, sports investment, sporting-cultural, sports exports, sports people-sports, sports achievements and media sports, and has a total of 50 indicators.
Conclusion:According to the results of the research and the identified indicators, the proposed model is a suitable theoretical model for sport indicators affecting the brand of the country.