bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimising Exome Prenatal Sequencing Services (EXPRESS): a study protocol to evaluate rapid prenatal exome sequencing in the NHS Genomic Medicine Service
Authors: Hill Melissa , Ellard Sian , Fisher Jane , Fulop Naomi , Knight Marian , Kroese Mark , Ledger Jean , Leeson-Beevers Kerry , McEwan Alec , McMullan Dominic , Mellis Rhiannon , Morris Stephen , Parker Michael , Tapon Dagmar , Baple Emma , Blackburn Laura , Choudry Asya , Lafarge Caroline , McInnes-Dean Hannah , Peter Michelle , Ramakrishnan Rema , Roberts Lauren , Searle Beverly , Smith Emma , Walton Holly , Wynn Sarah L. , Han Wu Wing , Chitty Lyn S. 
Published: July 2022

Background: Prenatal exome sequencing (ES) for the diagnosis of fetal anomalies was implemented nationally in England in October 2020 by the NHS Genomic Medicine Service (GMS). The GMS is based around seven regional Genomic Laboratory Hubs (GLHs). Prenatal ES has the potential to significantly improve NHS prenatal diagnostic services by increasing genetic diagnoses and informing prenatal decision-making. Prenatal ES has not previously been offered routinely in a national healthcare system and there are gaps in knowledge and guidance. Methods: Our mixed-methods evaluation commenced in October 2020, aligning with the start date of the NHS prenatal ES service. Study design draws on a framework developed in previous studies of major system innovation. There are five interrelated workstreams. Workstream-1 will use interviews and surveys with professionals, non-participant observations and documentary analysis to produce in-depth case studies across all GLHs. Data collection at multiple time points will track changes over time. In Workstream-2 qualitative interviews with parents offered prenatal ES will explore experiences and establish information and support needs. Workstream-3 will analyse data from all prenatal ES tests for nine-months to establish service outcomes (e.g. diagnostic yield, referral rates, referral sources). Comparisons between GLHs will identify factors (individual or service-related) associated with any variation in outcomes. Workstream-4 will identify and analyse practical ethical problems. Requirements for an effective ethics framework for an optimal and equitable service will be determined. Workstream-5 will assess costs and cost-effectiveness of prenatal ES versus standard tests and evaluate costs of implementing an optimal prenatal ES care pathway. Integration of findings will determine key features of an optimal care pathway from a service delivery, parent and professional perspective. Discussion: The proposed formative and summative evaluation will inform the evolving prenatal ES service to ensure equity of access, high standards of care and benefits for parents across England.
Implementasi Sistem Monitoring dan Kontrol Suhu Kelembaban Ruang Budidaya Jamur Berbasis IoT
Authors: Manik Dirgayusari Ayu , Sudiarsa I Wayan 
Published: July 2022

Kondisi lingkungan lembab sangat dibutuhkan jamur tiram untuk hidup dengan baik. Di dalam memonitoring serta menjaga kondisi kelembaban pada ruang budidaya jamur tiram petani jamur tiram masih melakukannya dengan cara manual yaitu memeriksa kondisi kumbung dan menyemprotkan air secara langsung pada baglog dan ruang budidaya jamur tiram ketika kondisi cuaca sedang panas atau kelembaban kurang dari batas yang telah ditentukan. Kegiatan tersebut mengharuskan pembudidaya sering bolak-balik ke tempat budidaya jamur guna melakukan pengecekan berulang terhadap keadaan ruang pembudidayaan jamur. Pada penelitian ini dibuat sebuah sistem untuk memonitoring serta mengontrol suhu kelembaban pada ruang pembudidayaan jamur tiram. Pada sistem yang telah dibuat menggunakan sensor DHT22 untuk mengukur suhu dan kelembaban pada ruang budidaya, hasil pengukuran akan ditampilkan melalui layar LCD 20x4 secara offline serta melalui aplikasi blynk pada smartphone. Ketika kondisi kelembaban salah satu sensor lebih kecil dari setpoint yang telah di inputkan pada keypad 4x3, maka akan ada pesan notifikasi dan relay akan menghidupkan pompa nozzle kabut. Kemudian ketika kelembaban pada ruang budidaya lebih besar dari setpoint maka pompa akan mati.
Sistem Informasi Administrasi Pada Kelompok Wanita Tani Laksmi Dewi Desa Ulakan
Authors: Suardana I Made Eka , Sugiartawan Putu 
Published: July 2022

The Women Farmers Group (KWT) Laksmi Dewi in Ulakan Village, most of whom are housewives, where this group is engaged in agribusiness development that aims to improve village food security. The activities of this group include the use of vacant land used as planting land, training on the use of agricultural land, and utilization of village resources related to agribusiness. KWT activities are generally funded from the organization's treasury which is sourced from government grants from the village, district, and provincial governments, funds from donors, remaining business proceeds, and other assistance funds. The problem that occurs is from administrative management to support group management. From this, it is recommended that a website-based administrative information system be the solution. This system will be designed and built in such a way that it can handle system functionality in the form of managing KWT members, managing KWT activities, and managing KWT funds related to income and sources of funds, utilization of funds and results or income from each activity.
Effectiveness of nitazoxanide in the treatment of COVID-19 related diarrhoea
Authors: Islam Md Nazrul , Chowdhury Sabikun Nahar , Zaman Md Monir Uz , Huq Md Zahirul 
Published: July 2022

Background: Diarrhoea is becoming one of the most prominent and troublesome manifestations in COVID-19 infection but no definitive treatment is available. So Nitazoxanide was used to see whether it can shorten the duration and sufferings form COVID-19 related diarrhoea.
Objective: To see the efficacy of Nitazoxanide in decreasing frequency and improving the consistency of stool in COVID-19 related diarrhoea.
Methods: This randomized comparative study was done in private chambers of medicine specialists in Khulna and patients admitted in corona dedicated hospital, Khulna from July 2020 to June 2021. 100 patients were enrolled in the study using Nitazoxanide & ORS (oral rehydration solution) in 50 patients and only ORS in another 50 patients. Decreased frequency and volume of stool at 24, 48 and 72 hours of both groups were compared.
Results: After giving Nitazoxanide in diarrhoea of COVID-19 patients, improvement was in 90% patients at 24 hours: in 96% patients in 48 hours and in 98% cases at 72 hours. On the other hand, without Nitazoxanide improvement was found in 30%, 40% and 50% cases at 24, 48 and 72 hours respectively. So Nitazoxanide was effective (p <0.05) at reducing frequency of diarrhoea and improving the consistency of stool.
Conclusion: Nitazoxanide significantly improves diarrhoea in COVID-19 patients by reducing duration of diarrhoea and improving consistency of stool.
Bang Med J Khulna 2021; 54 : 13-16
Comparison of back muscle and leg muscle strength among different groups of female medical students
Authors: Azad Samina , Hasan Khan Md Mohibul , Lia Shamima Hoque , Ara Shamim 
Published: July 2022

Background: Muscle strength is the ability of a muscle or muscle group to exert force. Good muscle strength increases physical performance and may be important in weight maintenance.
Objective: The present study aimed at comparing the back muscle and leg muscle strength among different groups of female medical students which might be used as base-line findings for other similar sedentary professionals.
Methods: A cross-sectional analytical study was conducted in the department of Anatomy, Dhaka Medical College, Dhaka, from January 2016 to December 2016. The study was performed on 118 female Bangladeshi medical students. It was conducted on three groups depending on body mass index- normal group, overweight group and obese group.
Results: Significant difference of mean back muscle and leg muscle strength was observed among normal, overweight and obese groups. The mean back muscle and leg muscle strength were higher in normal group than overweight group and lower in obese group. Significant difference (p=0.030) was observed between mean leg muscle strength of over-weight and obese group.
Conclusion: The results of the present study demonstrate that back muscle and leg muscle strength were significantly higher in normal group than overweight group and it is lower in obese group.
Bang Med J Khulna 2021; 54 : 17-20
Implication of serum hepcidin level in maintainance haemodialysis patients in association with different iron indices
Authors: Tarafder Palash , Choudhury Md Ayub Ali , Alam Md Babrul , Ahammod Tofael , Tarafder Pritish 
Published: July 2022

Background: Anaemia is a frequent complication in maintenance hemodialysis (MHD) patients and is associated with increased morbidity and mortality. Altered systemic iron metabolism and functional iron deficiency mainly related to subclinical inflammation makes it difficult to maintain proper control of anaemia. The discovery of hepcidin and it's functions has contributed to a better understanding of iron metabolism disorders in CKD anaemia.
Objective: To evaluate the association of serum hepcidin with different iron indices (serum iron, serum ferritin, TIBC and TSAT).
Materials and Methods: The study was carried out in the Institute of Kidney Diseases and Urology, Dhaka for a period of six months between July to December 2016. Serum hepcidin-25, current iron markers and other laboratory parameters were measured among study subjects. Absolute and functional iron deficiency patients were identified according to serum ferritin and TSAT. Statistical analysis was performed to find out whether serum hepcidin level significantly differ in MHD patients than healthy controls and also to evaluate it's correlation with other iron indices among MHD patients.
Results: Total 88 subjects (fifty MHD patients and thirty eight healthy controls) were enrolled into the study. Serum hepcidin level was significantly higher in MHD patients than healthy controls (19.3 (7.0 - 81.8) ng/ml vs 8.0 (2.4 - 33.6) ng/ml, P value <0.001). Hepcidin has significant positive correlation with ferritin in MHD patients (r=0.480; p=<0.001). Hepcidin was also positively correlated with serum ferritin both in absolute iron deficiency patients (r=0.786; p=0.036) and functional iron deficiency patients (r=0.764; p=0.006).
Conclusion: Serum hepcidin level is increased in MHD patients and associated with disturbance of iron metabolism. Hepcidin positively correlates with serum ferritin in MHD patients and may be used similarly as ferritin in guiding iron therapy.
Bang Med J Khulna 2021; 54 : 21-25
Giant aneurysm of the splenic artery
Authors: Osmane Rania , Ayadi Firas , Bacha Douha , Wael Ferjaoui 
Published: July 2022

Splenic artery aneurysms (SAA) are one of the common visceral aneurysms. However giant SAA have barely been reported. We discuss a case of SAA, who had prior history of caroli disease at the stage of secondary biliary cirrhosis for which he was a candidate for liver transplantation. The patient underwent open surgical repair. The proximal and distal spenic artery were ligated from within the aneurysm and surgery was completed with splenectomy. The post operative period was uneventful.
Bang Med J Khulna 2021; 54 : 26-27
PENGGUNAAN EKSTRAK JERUK KALAMANSI DAN EKSTRAK TAUGE UNTUK MENINGKATKAN MUTU PRODUK DALAM PEMBUATAN NATA DE COCO
Authors: Winarsih Lies , Aprira Aprira 
Published: July 2022

Salah satu mata praktikum kewirausahaan di laboratorium dasar adalah pembuatan nata de coco. Dalam proses pembuatan nata de coco dalam praktikum dan produksi masyarakat bengkulu selama ini masih menggunakan bahan kimia yaitu urea dan asam asetat yang berfungsi menyediakan energi untuk terbentuknya lapisan nata dan membuat suasana asam. Penggunaan asam asetat dan urea adalah bahan kimia yang dicampurkan dalam proses pembuatan makanan sehingga produk nata yang dihasilkan kurang diminati sebagian konsumen yang punya anggapan produk tersebut kurang sehat dan aman untuk dikonsumsi. Sehingga penulis berfikir untuk mencari bahan alternatif pengganti dari kedua bahan tersebut.Penelitian ini bertujuan untuk mengetahui apakah ekstrak tauge dan ekstrak jeruk kalamansi dapat digunakan sebagai pengganti urea/za dan asam asetat dalam pembuatan nata de coco serta bagaimana kualitas produknya jika dibandingkan dengan nata de coco yang pembuatannya dengan urea dan asam asetat sebagai nata de coco kontrol. Penelitian dilakukan dengan mengganti urea dan asam asetat dengan ekstrak tauge dan ekstrak jeruk kalamnsi dengan fariasi ekstrak tauge 10%,15% dan 20% serta ekstrak jeruk kalamnsi 2%,4% dan 6%, dari hasil penelitian didapatkan bahwa ekstrak tauge 10% dan 15% dengan 2% ekstrak jeruk kalamansi mendapatkan hasil yang signifikan dengan nata de coco control di lihat dari segi ketebalan da berat nata serta aspek organoleptis yang meliputi bau ,warna dan rasa.
ANALISIS RISIKO KERUSAKAN PADA ALAT BERAT GRAB DENGAN METODE FAILURE MODE AND EFFECT ANALYSIS (Study Kasus: PT SIAM MASPION TERMINAL GRESIK)
Authors: Rislamy Achmad Fany , Mahbubah Nina Aini , Widyaningrum Dzakiyah 
Published: July 2022

Preventive maintenance is considered as keypoint in maintenace management in order to maintain logistics’ steadiness along with pre and post production process. PT. Siam Maspion Terminal is one of the leading port’s service company which is provide logistics services on terminal port. Grab heavy eguipment is considered as the main equipment during looading and unloading process. Initial instigation found that inspite of periodically maintenance have been implemented, however, a high number of machine’s downtine have been identified. This study aims to analyze the cause and effect risk failure of grab’s components in order to mitigate alternative preventive maintenance using the FMEA approach. This research begins with downtime identification of five types of Grab heavy equipment, followed by identify the cause and effect such failure to determine ranking values based on the severity, frequency of occurrence, and detection. A number of espondents from the maintenance department were chosen as expert who filled out the FMEA questionnaire. This study found that there are six Grab components which are identified as critical component from Grab no 2 and Grab no 5. It was found that two highest failure risk are pulley and axle components. Regular maintenace recommendations based on these critical failure components are recommended in order to prevent such failure occur in the future.
Pembuatan Sarana Air Bersih Sumur Gali di Wilayah Kerja Puskesmas Palolo Kabupaten Sigi
Authors: Sasmita Hanum , Amsal Amsal , Novarianti Novarianti 
Published: July 2022

Humans need water as a necessity for life, they must meet various requirements in quality, quantity, and continuity. Dug wells are clean water facilities that are widely used by the community, both in urban and rural areas because dug wells are relatively easy and inexpensive to manufacture. The purpose of this activity was to procure pilot dug wells and increase public knowledge about dug wells that meet health requirements in the work area of ​​the Palolo Health Center, especially in Rahmat Village. The method used was a combination of lecture, discussion, and practice methods. The target was the community in Rahmat Village whose dug wells do not meet the requirements and conducted pilot construction of 1 dug well. The results of community service can be seen from the dug wells that have been made as pilots and the achievement of goals can be said to be good seen from the level of understanding and activeness of the participants in discussions and sharing information with other participants. The achievement of the material targets was good and seen from all the training materials delivered by the community service team. Suggestions, with the addition of one dug well unit, it is hoped that the community can maintain and maintain clean water facilities and increase public awareness of the importance of making dug wells that meet the requirements to improve health status.

ABSTRAK
Manusia membutuhkan air sebagai kebutuhan hidupnya harus memenuhi berbagai persyaratan, terutama kualitas, kuantitas dan kontinuitas. Sumur gali merupakan sarana air bersih yang banyak digunakan masyarakat, baik di perkotaan maupun di pedesaan karena sumur gali tergolong mudah dan murah pembuatannya. Tujuan pengadaan sumur gali percontohan serta bertambahnya pengetahuan masyarakat tentang sumur gali yang memenuhi persyaratan kesehatan di wilayah kerja Puskesmas Palolo khususnya di Desa Rahmat. Metode yang digunakan dalam kegiatan ini adalah penggabungan metode ceramah, diskusi dan praktik. Sasaran adalah masyarakat di Desa Rahmat yang sumur galinya belum memenuhi syarat dan melakukan pembuatan percontohan sumur gali sebanyak 1 buah. Hasil dari pengabdian masyarakat dapat dilihat dari telah dibuatnya sumur gali sebagai percontohan dan ketercapaian tujuan dapat dikatakan baik dilihat dari tingkat pemahaman dan keaktifan para peserta dalam diskusi dan berbagi informasi dengan peserta lainnya. Ketercapaian target materi dapat dikatakan baik dilihat dari semua materi pelatihan yang disampaikan oleh tim pengabdian kepada masyarakat. Saran, dengan adanya penambahan satu unit sumur gali, diharapkan masyarakat dapat menjaga dan memelihara sarana air bersih sumur gali serta adanya peningkatan kesadaran masyarakat akan pentingnya pembuatan sumur gali yang memenuhi persyaratan sehingga dapat meningkatkan derajat kesehatan.
Penggunaan Pendekatan Emo-Demo dalam Edukasi Pencegahan Stunting pada Orang Tua Siswa Taman Kanak-kanak
Authors: Yustiyani Yustiyani , Nurmansyah Mochamad 
Published: July 2022

Stunting is one of many health problems in Indonesia than needs to be addressed through intervention program such as nutrition sensitive program. The objective of this community service program was to improve parental knowledge on stunting prevention using emotional demonstration (emo-demo) approach. The program was held on January 20, 2022, at Legoso kindergarten, South Tangerang city. The program participants consisted of 16 kindergarten student parents. The program blended the lecture and game session using emo demo approach. The emo-demo module was developed based on a guideline by GAIN. The participants characteristics as well as knowledge before and after the program was measured using a set of pre and post-test questionnaire on Google Form. Most of participants were female (93,8%), aged 31-40 years old (75,0%) with diploma or bachelor’s degree (68,8%). Almost all participants have heard about stunting prior to joining this program (93,8%). The information of stunting was obtained from social media/internet (56,3%), television/radio (50,0%) and came from families (31,3%), friends (31,3%), public figures (31,3%) and health care professionals (25%). We found significant improvement of the average participant’s knowledge on stunting from 17,25 ± 5,59 points to 23,58 ± 6,79 points at the end of the program (p=0,02). Emo-demo is one of the methods could be used to educate public especially related to stunting issue.

ABSTRAK
Stunting masih menjadi permasalahan kesehatan di Indonesia yang membutuhkan penanganan, salah satunya melalui intervensi gizi sensitif. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan orang tua siswa dalam pencegahan stunting pada anak usia dini dengan menggunakan pendekatan emo-demo. Kegiatan penyuluhan dilaksanakan pada 20 Januari 2022 di TK di Legoso, Tangerang Selatan. Peserta penyuluhan terdiri atas 16 orang tua siswa. Penyuluhan dilakukan dengan metode ceramah dan permainan menggunakan pendekatan emo-demo. Pengembangan modul emo-demo merujuk pada pedoman pengembangan oleh Global Alliance for Improved Nutrition (GAIN). Karakteristik peserta dan pengetahuan sebelum dan sesudah mengikuti penyuluhan diukur menggunakan kuesioner pre dan post-test dengan media Google Form. Sebagian besar peserta adalah perempuan (93,8%), berusia 31-40 tahun (75,0%), dan memiliki pendidikan terakhir diploma/sarjana (68,8%). Hampir seluruh peserta pernah mendengar istilah stunting sebelum mendapatkan penyuluhan (93,8%). Informasi tentang stunting diperoleh dari sosial media/internet (56,3%), televisi/radio (50,0%) dan berasal dari keluarga (31,3%), teman (31,3%), tokoh masyarakat (31,3%) dan tenaga kesehatan (25%). Terdapat peningkatan rata-rata skor pengetahuan peserta yang signifikan dari 17,25 ± 5,59 menjadi 23,58 ± 6,79 setelah mendapatkan penyuluhan (p=0,02). Emo-demo dapat menjadi salah satu metode yang efektif dalam pemberian edukasi bagi masyarakat khususnya terkait stunting.
Pemanfaatan Konseling ASI Eksklusif Menggunakan Media Leaflet pada Calon Pengantin
Authors: Al Rahmad Agus Hendra , Hadi Abdul , Miko Ampera , Ahmad Apripin 
Published: July 2022

The success of exclusive breastfeeding is largely determined by the knowledge of the mother and husband. It should be, the bride and groom need to be given education in the form of counseling about exclusive breastfeeding using leaflet media to support the 1000 HPK efforts and reduce the prevalence of stunting. The purpose of this activity is to provide exclusive breastfeeding counseling using leaflet media to prospective brides in Banda Aceh City. The service is carried out with a non-equivalent group pretest-posttest approach with the aim of being totaling 20 grooms and brides. This service was carried out in Banda Aceh City in 2019. Counseling is carried out by professional counselors using leaflet media. Knowledge before and after counseling was measured by interview. The evaluation was carried out statistically using the Dependent t-test. The results show that counseling for prospective brides can significantly increase knowledge about exclusive breastfeeding (p= 0.003) in Banda Aceh City, the knowledge increased from 26,3 to 33,1. In conclusion, exclusive breastfeeding counseling to prospective brides is very useful in increasing nutritional knowledge.

ABSTRAK
Keberhasilan pemberian ASI secara eksklusif sangat ditentukan oleh pengetahuan ibu dan suami. Sudah seharusnya, calon pengantin perlu diberikan edukasi berupa konseling tentang ASI esklusif menggunakan media leaflet dalam mendukung upaya 1000 HPK serta menurunkan prevalensi stunting. Tujuan kegiatan ini adalah untuk memberikan konseling ASI eksklusif menggunakan media leaflet kepada calon pengantin di Kota Banda Aceh. Pengabdian dilakukan pendekatan pretest posttest non equivalent group dengan sasaran yang berjumlah 20 calon pengantin pria dan wanita. Pengabdian ini dilakukan di Kota Banda Aceh pada tahun 2019. Konseling dilaksanakan oleh Konselor professional menggunakan media leaflet. Pengetahuan sebelum dan setelah konseling diukur secara wawancara. Evaluasi dilakukan secara statistik menggunakan uji Dependent t-test. Hasil menunjukkan bahwa konseling pada calon pengantin dapat meningkatkan pengetahuan tentang ASI eksklusif secara signifikan (p= 0,003) di Kota Banda Aceh, pengetahuan meningkat dari 26,3 menjadi 33,1. Kesimpulan, konseling ASI eksklusif kepada calon pengantin sangat bermanfaat dalam meningkatkan pengetahuan gizi.