bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer Prevention from the Viewpoint of UVA Comprehensive Cancer Center
Authors: Loughran Thomas P. , Cohn Wendy , Bonilla Gloribel , Anderson Roger T. 
Published: November 2022

Abstract
Prevention is a cornerstone of the guiding mission of the University of Virginia Comprehensive Cancer Center, which is “to reduce the burden of cancer for the patients of today, through skilled, integrated, and compassionate care and to eliminate the threat of cancer for the patients of tomorrow, through research and education in an environment that promotes diversity, equity, and inclusion.” We find it useful to conceptualize different opportunities for cancer prevention using NCI's Health Behaviors Research Branch's multilevel translational framework. The latter considers three intersecting continuums: cancer control—from prevention through survivorship; translation—from basic sciences to dissemination and implementation; and level of influence or impact—from genetics to policy. An advantage of this heuristic is that “prevention” is inherently defined as an inter-programmatic concept cutting across basic, clinical, and population science research rather than solely as a programmatic domain of Population Sciences. Through the UVA community outreach and engagement, we apply this multilevel framework to mitigate the social determinants of cancer risk and outcomes that drive cancer inequities in our catchment area. Below, we provide examples of our prevention research and translation along the model continuums and focus on equity.
Surveying Mechanisms of Immune Checkpoint Blockade from a VISTA
Authors: Wei Spencer C. 
Published: November 2022

Abstract
Defining the mechanisms of action of immune checkpoint blockade therapies is essential for effectively designing combination therapeutic approaches and developing the next generation of immunotherapies. In this issue, Schaafsma and colleagues report that V-domain immunoglobulin suppressor of T-cell activation antagonism acts through mechanisms distinct from anti–CTLA-4 and anti—programmed cell death protein 1 via remodeling of the myeloid-cell compartment and modulating T-cell quiescence.
See related article by Schaafsma et al. p. 38 (1).
Pengaruh Kualitas Pelayanan Food Delivery pada Gojek terhadap Kepua-san Pelanggan Studi pada Mahasiswa Institut Stiami
Authors: Vikaliana Resista , Astusti Widya Hastri , Nurhasanah Siti , Irwansyah Irwansyah 
Published: November 2022

Fitur GoFood yang disediakan oleh Go-jek adalah layanan pesan-antar (delivery) yang disediakan Go-jek untuk membelikan dan mengantarkan makanan kepada penggunanya. Go-jek dengan persaiangan yang ketat terutama dengan pesaing terkuatnya yaitu Grab-food memiliki kelebihan seperti kelengkapan jenis restoran yang tersedia dibanding applikasi lainnya atau serupa. Keberhasilan GoJek dalam memberikan layanan pesan antar makanan terbilang sukses dengan jumlah konsumen dan patner pemilik usaha yang terbilang banyak. Kualitas pelayanan menjadi salah satu unsur terpenting untuk memperoleh kepuasan konsumen.
Penelitian ini menggunakan metode kuantitatif dengan populasi adalah mahasiswa pengguna aplikasi Go-food pada Go-jek di Institut Stiami Kampus Bekasi B yang menggunakan aplikasi Go-food pada Go-jek. Sampel dalam penelitian ini sebanyak 100 orang, kemudian data diolah dengan menggunakan alat uji analisis statistik SPSS 21.
Hasil dari penelitian ini menunjukkan bahwa terdapat pengaruh pengaruh kualitas pelayanan food delivery pada Gojek terhadap kepuasan pelanggan dari Mahasiswa Institut Stiami Kampus Bekasi B. Besarnya pengaruh kualitas pelayanan food delivery pada Gojek terhadap kepuasan pelanggan dari Mahasiswa Institut Stiami Kampus Bekasi B sebesar 70,0%.
Backlash to Climate Policy
Authors: Patterson James J. 
Published: November 2022

Abstract
Hard climate policy (e.g., regulation, taxes/pricing, phaseouts) is needed to meet ambitious climate targets, but when such policy is introduced, it can sometimes trigger backlash. Backlash involves an abrupt and forceful negative reaction by a significant number of actors seeking to reverse a policy, often through extraordinary means that transgress established procedures and norms. Yet, explanations of policy backlash remain nascent and fragmented. I synthesize insights from within and beyond climate politics to argue that contested legitimacy is central to climate policy backlash, which provokes attempts toward delegitimation. I develop a conceptual pathway to explain the occurrence of climate policy backlash and generate hypotheses about how practices of delegitimation occur, and their effects. This contributes to explaining why backlash occurs, highlighting ideational factors alongside interests and institutions. Overall, I suggest the need for a contextually embedded approach to understanding the volatile dynamics of backlash, bringing political sociology into conversation with political economy.
“Who Knows?”: A Bakhtinian Reading of Carnivalesque Motifs in Jonah
Authors: McNinch Timothy C. 
Published: November 2022

Abstract
This brief study dialogues with Mikhail Bakhtin’s insights to evaluate the rhetoric of Jonah’s humor. The “carnivalesque” lens invites the reader to revel in the dialogic dissonances of the book, for in carnival fashion, the humor of Jonah counters the seriousness of a seemingly determined world with the liberating laughter of open-ended ambiguity. In Jonah, social hierarchies are collapsed, the hero is debased, and the world is depicted in grotesque and hyperbolic form. By embodying a “carnival sense of the world,” the humor in Jonah wonders aloud: What if the world is not as simple, ordered, and predictable as the prophetic voice often assumes? That idea is provoked and prodded by embodying the idea of “the prophet” in the character of Jonah and dropping him into unusual circumstances, as an authentically open-ended, literary, thought experiment. In that experiment, “Who knows?” Anything could happen.
An observation of attempted infanticide and female–female cooperation in wild plains zebras (Equus quagga)
Authors: Hex Severine B.S.W. , Mwangi Margaret , Warungu Rosemary , Rubenstein Daniel I. 
Published: November 2022

Abstract
Male infanticide has been reported in a wide range of taxa as a strategy for redirecting maternal investment and increasing a male’s chance of siring future offspring. Plains zebras (Equus quagga) possess many of the social organization and life history traits found to favour infanticide. However, most documented cases are from captive animals, while it has not been detected in studies of free-ranging populations. Here, we report an apparent infanticide attempt in which the historical associations of all participants were known. In addition, we report the first instance of non-kin female–female cooperative defence against male aggression in this species. We discuss why this behaviour may not have been observed by other longitudinal studies. We then explore how intraspecific and inter-individual variation may factor into its relative rarity, how the reproductive biology of plains zebras relates to this behaviour, and how female–female cooperation between non-kin can operate as an effective counterstrategy.
More opportunities to peck for identical food availability increases foraging efficiency in pigeons
Authors: Wittek Neslihan , Oeksuez Fatma , Güntürkün Onur , Anselme Patrick 
Published: November 2022

Abstract
The opportunity and the information available to secure food resources drives foraging behaviour. We tested how inconsistent hole-food pairings and coverings could alter foraging performance, even when food availability is held constant. In our first experiment, we exposed pigeons (Columba livia) to a board in which each of the 60 covered holes contained one food item and to another board in which only one third of the 180 covered holes randomly contained one food item. In a second experiment, only the 60-hole board was used and the holes were not covered. The pigeons increased their body weight, gave fewer pecks per hole, revisited holes less often, and inspected fewer adjacent holes with 180 rather than 60 covered holes while eating similar amounts. However, their pecks were disproportionately higher near the edges of the board with 60 covered holes. This behaviour was not evident in the second experiment, when the food items were visible and individuals could know where food was available. Thus, the information about food location may drive foraging behaviour more directly than the information about food availability.
Predictors of response to anti-CGRP monoclonal antibodies: a 24-week, multicenter, prospective study on 864 migraine patients
Authors: Barbanti Piero , Egeo Gabriella , Aurilia Cinzia , Altamura Claudia , d’Onofrio Florindo , Finocchi Cinzia , Albanese Maria , Aguggia Marco , Rao Renata , Zucco Maurizio , Frediani Fabio , Filippi Massimo , Messina Roberta , Cevoli Sabina , Carnevale Antonio , Fiorentini Giulia , Messina Stefano , Bono Francesco , Torelli Paola , Proietti Stefania , Bonassi Stefano , Vernieri Fabrizio ,   for the Italian Migraine Registry study group
Published: November 2022

Abstract
Background and objectives
The identification of predictors of response to antiCGRP mAbs could favor tailored therapies and personalized treatment plans. This study is aimed at investigating predictors of ≥ 50%, ≥ 75% and 100% response at 24 weeks in patients with high-frequency episodic (HFEM: 8–14 days/month) or chronic migraine (CM).

Methods
This is a large, multicenter, cohort, real-life study. We considered all consecutive adult patients affected by HFEM or CM who were prescribed antiCGRP mAbs for ≥ 24 weeks in 20 headache centers. Patients were interviewed face-to-face using a shared semi-structured questionnaire carefully exploring socio-demographic and clinical characteristics. Patients received subcutaneous erenumab (70 mg or140 mg, monthly), galcanezumab (120 mg monthly, following a 240 mg loading dose), or fremanezumab (225 mg, monthly or 675 mg, quarterly) according to drug market availability, physician’s choice, or patient’s preference. The primary endpoint of the study was the assessment of ≥ 50% response predictors at 24 weeks. Secondary endpoints included ≥ 75% and 100% response predictors at 24 weeks.

Results
Eight hundred sixty-four migraine patients had been treated with antiCGRP mAbs for ≥ 24 weeks (erenumab: 639 pts; galcanezumab: 173 pts; fremanezumab: 55 pts). The ≥50% response (primary endpoint) in HFEM was positively associated with unilateral pain (UP) + unilateral cranial autonomic symptoms (UAs) (OR:4.23, 95%CI:1.57–11.4; p = 0.004), while in CM was positively associated with UAs (OR:1.49, 95%CI:1.05–2.11; p = 0.026), UP + UAs (OR:1.90, 95%CI:1.15–3.16; p = 0.012), UP + allodynia (OR:1.71, 95%CI:1.04–2.83; p = 0.034), and negatively associated with obesity (OR:0.21, 95%CI:0.07–0.64; p = 0.006). The 75% response (secondary endpoint) was positively associated with UP + UAs in HFEM (OR:3.44, 95%CI:1.42–8.31; p = 0.006) and with UP + UAs (OR:1.78, 95%CI:1.14–2.80; p = 0.012) and UP + allodynia (OR:1.92, 95%CI:1.22–3.06; p = 0.005) in CM. No predictor of 100% response emerged in patients with HFEM or CM.

Conclusions
A critical evaluation of headache characteristics indicating peripheral or central sensitization may help in predicting responsiveness to antiCGRP mAbs in HFEM and CM. A more precise pain profiling may represent a steppingstone for a mechanism-based approach and personalized treatment of migraine with compounds targeting specific molecular mechanisms.
MLAGO: machine learning-aided global optimization for Michaelis constant estimation of kinetic modeling
Authors: Maeda Kazuhiro , Hatae Aoi , Sakai Yukie , Boogerd Fred C. , Kurata Hiroyuki 
Published: November 2022

Abstract
Background
Kinetic modeling is a powerful tool for understanding the dynamic behavior of biochemical systems. For kinetic modeling, determination of a number of kinetic parameters, such as the Michaelis constant (Km), is necessary, and global optimization algorithms have long been used for parameter estimation. However, the conventional global optimization approach has three problems: (i) It is computationally demanding. (ii) It often yields unrealistic parameter values because it simply seeks a better model fitting to experimentally observed behaviors. (iii) It has difficulty in identifying a unique solution because multiple parameter sets can allow a kinetic model to fit experimental data equally well (the non-identifiability problem).

Results
To solve these problems, we propose the Machine Learning-Aided Global Optimization (MLAGO) method for Km estimation of kinetic modeling. First, we use a machine learning-based Km predictor based only on three factors: EC number, KEGG Compound ID, and Organism ID, then conduct a constrained global optimization-based parameter estimation by using the machine learning-predicted Km values as the reference values. The machine learning model achieved relatively good prediction scores: RMSE = 0.795 and R2 = 0.536, making the subsequent global optimization easy and practical. The MLAGO approach reduced the error between simulation and experimental data while keeping Km values close to the machine learning-predicted values. As a result, the MLAGO approach successfully estimated Km values with less computational cost than the conventional method. Moreover, the MLAGO approach uniquely estimated Km values, which were close to the measured values.

Conclusions
MLAGO overcomes the major problems in parameter estimation, accelerates kinetic modeling, and thus ultimately leads to better understanding of complex cellular systems. The web application for our machine learning-based Km predictor is accessible at https://sites.google.com/view/kazuhiro-maeda/software-tools-web-apps, which helps modelers perform MLAGO on their own parameter estimation tasks.
Identification of quantitative trait loci for related traits of stalk lodging resistance using genome-wide association studies in maize (Zea mays L.)
Authors: Wu Lifen , Zheng Yunxiao , Jiao Fuchao , Wang Ming , Zhang Jing , Zhang Zhongqin , Huang Yaqun , Jia Xiaoyan , Zhu Liying , Zhao Yongfeng , Guo Jinjie , Chen Jingtang 
Published: November 2022

Abstract
Background
Stalk lodging is one of the main factors affecting maize (Zea mays L.) yield and limiting mechanized harvesting. Developing maize varieties with high stalk lodging resistance requires exploring the genetic basis of lodging resistance-associated agronomic traits. Stalk strength is an important indicator to evaluate maize lodging and can be evaluated by measuring stalk rind penetrometer resistance (RPR) and stalk buckling strength (SBS). Along with morphological traits of the stalk for the third internodes length (TIL), fourth internode length (FIL), third internode diameter (TID), and the fourth internode diameter (FID) traits are associated with stalk lodging resistance.

Results
In this study, a natural population containing 248 diverse maize inbred lines genotyped with 83,057 single nucleotide polymorphism (SNP) markers was used for genome-wide association study (GWAS) for six stalk lodging resistance-related traits. The heritability of all traits ranged from 0.59 to 0.72 in the association mapping panel. A total of 85 significant SNPs were identified for the association mapping panel using best linear unbiased prediction (BLUP) values of all traits. Additionally, five candidate genes were associated with stalk strength traits, which were either directly or indirectly associated with cell wall components.

Conclusions
These findings contribute to our understanding of the genetic basis of maize stalk lodging and provide valuable theoretical guidance for lodging resistance in maize breeding in the future.
Epidemiology of carbapenem-resistant Klebsiella pneumoniae ST15 of producing KPC-2, SHV-106 and CTX-M-15 in Anhui, China
Authors: Zhao Hang , He Zhien , Li Yujie , Sun Baolin 
Published: November 2022

Abstract
Background:
It is well known that carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a more problematic public health issue due to its widespread spread worldwide. In China, ST11-type CRKP is the most prevalent CRKP, but ST15-type CRKP, a recently prevalent high-risk clone, has emerged widely throughout China, posing a serious public health risk. Therefore, we conducted an epidemiological of an outbreak of ST15 CRKP of producing CTX-M-15, KPC-2 and SHV-106 in a tertiary hospital in Anhui, China, to Understanding the potential risks of the current STT15 CRKP outbreak.

Results:
From July 2021 to December 2021, 13 ST15 CRKP isolates were identified by collecting non-repeated clinical multidrug-resistant isolates, with all capsular typing of serotype KL19. All ST15 CRKP isolates were resistant to cephalosporins, carbapenems and quinolones, but were sensitive to amikacin, tigecycline and polymyxin B. In addition, isolates carried blaSHV−106 (100%), blaKPC−2 (69%), blaCTX−M−15 (69%), blaTEM−1B (69%), blaOXA−1 (62%) and blaLAP−2 (8%), as well as iron chelators (iutA, ybt, fyuA, ent, fepA, irp1, irp2, 100%) were detected. In phenotyping experiments, all ST15 CRKP exhibited lower growth rates than NTUH-K2044, and all ST15 CRKP did not exhibit mucoviscositty characteristics. However, in the Galleria mellonella infection model, isolates 21081212, 21081241 and 21091216 were more lethal than the hypervirulent isolates NTUH-K2044. Sequencing results showed that the genetic environment surrounding the genes blaSHV−106, blaKPC−2, blaCTX−M−15, blaOXA−1 and blaTEM−1B were all identical in the ST15 CRKP isolates. Phylogenetic analysis showed that 13 ST15 CRKP isolates were divided into three subgroups, and when placed in global analysis, 10 of them were highly homologous to isolates from Jiangsu, two were highly homologous to isolates from Zhejiang, and one was homologous to an isolate from an unlabelled region.

Conclusion:
Our research shows that ST15 CRKP, which carries multiple β-lactamases genes and siderophores-encoding genes, may be evolving to hypervirulence and may have spread widely in localised areas. Therefore, environmental surveillance and clinical infection control in hospitals should be strengthened to prevent further spread of ST15 CRKP.
Developmentally regulated mitochondrial biogenesis and cell death competence in maize pollen
Authors: Chamusco Karen C. , Milazzo May N. , Bhan Kanchan S. , Kamps Terry L. , Smith Prestina , Durojaiye Modupeoluwa , Moreira Cristina D. , Gallo Maria , Chase Christine D. 
Published: November 2022

AbstractBackgroundCytoplasmic male sterility (CMS) is a maternally inherited failure to produce functional pollen that most commonly results from expression of novel, chimeric mitochondrial genes. InZea mays, cytoplasmic male sterility type S (CMS-S) is characterized by the collapse of immature, bi-cellular pollen. Molecular and cellular features of developing CMS-S and normal (N) cytoplasm pollen were compared to determine the role of mitochondria in these differing developmental fates.ResultsTerminal deoxynucleotidyl transferase dUTP nick end labeling revealed both chromatin and nuclear fragmentation in the collapsed CMS-S pollen, demonstrating a programmed cell death (PCD) event sharing morphological features with mitochondria-signaled apoptosis in animals. Maize plants expressing mitochondria-targeted green fluorescent protein (GFP) demonstrated dynamic changes in mitochondrial morphology and association with actin filaments through the course of N-cytoplasm pollen development, whereas mitochondrial targeting of GFP was lost and actin filaments were disorganized in developing CMS-S pollen. Immunoblotting revealed significant developmental regulation of mitochondrial biogenesis in both CMS-S and N mito-types. Nuclear and mitochondrial genome encoded components of the cytochrome respiratory pathway and ATP synthase were of low abundance at the microspore stage, but microspores accumulated abundant nuclear-encoded alternative oxidase (AOX). Cytochrome pathway and ATP synthase components accumulated whereas AOX levels declined during the maturation of N bi-cellular pollen. Increased abundance of cytochrome pathway components and declining AOX also characterized collapsed CMS-S pollen. The accumulation and robust RNA editing of mitochondrial transcripts implicated translational or post-translational control for the developmentally regulated accumulation of mitochondria-encoded proteins in both mito-types.ConclusionsCMS-S pollen collapse is a PCD event coincident with developmentally programmed mitochondrial events including the accumulation of mitochondrial respiratory proteins and declining protection against mitochondrial generation of reactive oxygen species.
Nasopharyngeal aspirates in children with severe community-acquired pneumonia collected within 3 days before bronchoscopy can partially reflect the pathogens in bronchoalveolar lavage fluids
Authors: Zhu Qiguo , Zhou Junli , Li Fei , Shi Peng , Lu Yi , Lin Xiaoliang , Yuan Lin , Zhuo Zhiqiang , Shen Jun 
Published: November 2022

Abstract
Background
There is little evidence about consistency between nasopharyngeal and pulmonary pathogens in children with severe pneumonia. This study aims to compare the difference of pathogens between nasopharyngeal aspirates (NPAs) collected before bronchoscopy and bronchoalveolar lavage fluids (BALFs) in children with severe community-acquired pneumonia (SCAP).

Methods
NPAs and BALFs were collected form pediatric SCAP cases hospitalized from January 2018 to March 2019. NPAs were colleced within 3 days before bronchoscopy. Samples were detected by direct immunofluorescence assay (DFA) for seven respiratory viruses and by routine bacterial culture in the clinical microbiology laboratory. Respiratory syncytial virus (RSV), Adenovirus (ADV), Influenza virus types A, B (IV-A and IV-B), Parainfluenza virus 1–3 (PIV1-3) were detected with a commercial assay. The virological and bacteriological detention results of NPAs were compared with the results of BALFs.

Results
In total 204 cases with mean age of 3.4 ± 2.8 years (IQR, 1 month-14 years) were included in the study. Both NPA and BALF were collected from those cases. The positive rates of pathogen in NPAs and BALFs were 25.0% (51/204) and 36.7% (75/204), respectively (x2 = 6.614, P = 0.010). Respiratory viruses were found in 16.1% (33/204) from NPAs and 32.3% (66/204) from BALFs (x2 = 14.524, P < 0.001). RSV and ADV were the two most frequent detected viruses in NPAs and BALFs. High consistentcy of pathogens between NPAs and BALFs was observed, and 96.9% (32/33) viruses detected in NPAs were also found in BALFs. While bacteria were isolated from 12.7% (26/204) and 10.7% (22/204) of the two kinds of samples, respectively (x2 = 0.378, P = 0.539). In addition, Haemophilus influenzae (HI) was the dominant germ in both samples.

Conclusion
The DFA method used to detect seven respiratory viruses from NPAs collected within 3 days before bronchoscopy can partially reflect the pathogens in the lungs in children with SCAP.