bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute cardiovascular effects associated with the use of prescription medications: A Danish nationwide screening study
Authors: Abbasi Saad Hanif , Lund Lars Christian , Hallas Jesper , Ernst Martin Thomsen , Pottegård Anton 
Published: February 2025

AbstractAimThis study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications.MethodsThis Danish nationwide screening study was conducted among incident cases of cardiovascular diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE), myocarditis, and atrial fibrillation (AF), between January 2000 and December 2022. Using a case‐crossover study design, we examined exposure to individual drugs on the date of the cardiovascular event (focal date) and three reference dates corresponding to days −180, −270 and −360 prior to index date. We calculated odds ratios (ORs) with 95% credible intervals (CIs) for associations between exposure drug and cardiovascular outcomes using the conditional logistic regression with a weak Bayesian shrinkage.ResultsAfter applying exclusion criteria, we identified 191,979 cases of AF, 145,148 cases of MI, 132,271 cases of IS, 71,821 cases of HF, 16,127 cases of VTE and 10,045 cases of myocarditis. Based on the threshold for the strength of associations (OR ≥ 1.5; lower limit of CI ≥ 1), we identified 222 associations for 104 individual drugs across all six outcomes. Some major drug classes, such as antibiotics, analgesics and corticosteroids, consistently demonstrated associations for most cardiovascular outcomes. Use of pantoprazole, in contrast to other PPIs, was associated with AF (OR 1.83; 95% CI 1.68–2.00) along with MI, HF, myocarditis and VTE. Similarly, oxazepam stood out among other benzodiazepines and demonstrated increased risk of VTE (OR 2.53; 95% CI 1.55–4.13) as well as MI, HF and AF.ConclusionsThe results highlight several potentially important associations across various pharmacological drug classes that warrant further investigation in tailored pharmacoepidemiological analyses.
Photoluminescence Properties of Novel Ca3Y2B4O12:Eu3+ and Dy3+ Phosphors for Solid‐State Lighting Prepared by Combustion Method
Authors: Nandanwar C. M. , Kokode N. S. , Yerpude A. N. , Uke A. M. 
Published: February 2025

ABSTRACTIn this study, novel Ca3Y2B4O12:Eu3+ and Dy3+ phosphors were synthesized utilizing a simple and efficient combustion process. The Ca3Y2B4O12 host orthorhombic phase with high crystallinity formation is confirmed by structural x‐ray diffraction analysis. The Ca3Y2B4O12:Eu3+ phosphors PL study indicated different emission peaks at 595 and 618 nm under 397 nm excitation, whereas Ca3Y2B4O12:Dy3+ phosphors emission peaks displayed blue (485 nm) and yellow (579 nm) under 353 nm excitation. The ideal doping concentration of 0.5 mol% for Eu3+ and Dy3+ ions resulted in maximum emission intensity due to reduced concentration quenching effects. The chromaticity coordinates show that the emissions are in the visible spectrum, with high‐purity colors suitable for solid state lighting. The results indicate that novel Ca3Y2B4O12:Eu3+ and Dy3+ is promising materials for n‐UV emitting phosphors for solid‐state lighting applications.
A Novel Molecular Profile of Hormone‐Sensitive Prostate Cancer Defines High Risk Patients
Authors: Piombino Claudia , Nasso Cecilia , Bettelli Stefania , Manfredini Samantha , Vitale Maria Giuseppa , Pipitone Stefania , Baldessari Cinzia , Costantini Matteo , Eccher Albino , Mastrolia Ilenia , Catani Virginia , Bacchelli Francesca , Ferretti Stefania , Dominici Massimo , Sabbatini Roberto 
Published: February 2025

ABSTRACTBackgroundThe therapeutic management of metastatic hormone‐sensitive prostate cancer (mHSPC) is still based on clinical and pathological parameters due to the lack of biomarkers that may drive tailored treatment.MethodsIn this non‐randomized, single‐center, retrospective trial, we searched for a genetic signature using the NanoString nCounter PanCancer Pathways Panel on formalin‐fixed paraffin embedded prostate cancer samples belonging to 48 patients with de novo or relapsed mHSPC. Patients were divided into a high‐clinical‐risk group (n = 36) and a low‐clinical‐risk group (n&amp;#x02009;=&amp;#x02009;12) according to the mean time to metastatic relapse.ResultsThe analysis of Nanostring nCounter Panel data revealed differential expression of 42 genes between high‐clinical‐risk and low‐clinical‐risk groups. All the genes except for NR4A1 and FOS were upregulated in the high‐clinical‐risk group. A general overexpression of apoptosis, PI3K and MAPK pathway‐related genes, including AKT2, was observed in the high‐clinical‐risk group.ConclusionThe differential genetic signature identified between the two study groups revealed novel biomarkers in mHSPC, additionally suggesting new therapeutic targets within the hormone sensitive phase, such as AKT2. Further prospective larger cohort studies are needed to assess the prognostic value of our findings and their exact role in prostate cancer progression.
Real‐Life Impact of Enfortumab Vedotin or Chemotherapy in the Sequential Treatment of Advanced Urothelial Carcinoma: The ARON‐2 Retrospective Experience
Authors: Rizzo Mimma , Morelli Franco , Ürün Yüksel , Buti Sebastiano , Park Se Hoon , Bourlon Maria T. , Grande Enrique , Massari Francesco , Landmesser Johannes , Poprach Alexandr , Takeshita Hideki , Roviello Giandomenico , Myint Zin W. , Popovic Lazar , Soares Andrey , Abahssain Halima , Giannatempo Patrizia , Molina‐Cerrillo Javier , Incorvaia Lorena , Salah Samer , Zeppellini Annalisa , Monteiro Fernando Sabino Marques , Porta Camillo , Gupta Shilpa , Santoni Matteo 
Published: February 2025

ABSTRACTBackgroundRecently, a plethora of novel systemic agents have been incorporated into the therapeutic armamentarium of advanced urothelial carcinoma (aUC). The antibody–drug conjugate (ADC), enfortumab vedotin (EV), has demonstrated relevant clinical benefit in patients with aUC refractory to platinum and immune‐checkpoint inhibitor (ICI) therapy. Our study provides a retrospective, international, real‐world analysis comparing the effectiveness of EV to chemotherapy in this setting.MethodsThe data were extracted from the medical records of patients treated with EV or chemotherapy following pembrolizumab for recurrent or progressive aUC after platinum‐based chemotherapy. Patients were assessed for overall survival (OS), progression‐free survival (PFS), overall response rate (ORR) and duration of response (DoR).ResultsOur analysis included 247 patients treated with EV (88, 36%) or chemotherapy (159, 64%). Median OS was 9.1 months (95%CI 7.2–10.7) in the overall study population, 13.6 months (95%CI 10.0–31.0) in patients receiving EV and 6.8 months (95%CI 6.0–8.9) in patients receiving chemotherapy (p < 0.001). The OS benefit of EV was not affected by primary tumour site and histology, metastatic sites, type of first platinum‐based chemotherapy or response to pembrolizumab. In the EV cohort, the median PFS was significantly longer (8.8 months [95%CI 6.5–17.0] vs. 3.0 months [95%CI 2.6–3.7]) and the ORR was significantly higher (56% vs. 23%) than in the chemotherapy cohort.ConclusionsThe results of our international analysis of real‐world data confirm the effectiveness of EV in the sequential strategy of aUC patients who have received prior platinum‐based chemotherapy and anti‐PD‐1 pembrolizumab, regardless of commonly considered prognostic factors.Trial Registration: ClinicalTrials.gov identifier: NCT05290038
Robust HPV‐16 Detection Workflow for Formalin‐Fixed Cancer Tissue and Its Application for Oral Squamous Cell Carcinoma
Authors: Morodomi Shizuka , Hirosue Akiyuki , Rahman Akhinur , Nohata Kyotaro , Matsuo Misaki , Reda Omnia , Alam Rajib Samiul , Saito Haruki , Takeda Hiroki , Yoshida Ryoji , Nakamoto Masafumi , Hirayama Masatoshi , Kawahara Kenta , Takatori Mitsuyoshi , Orita Yorihisa , Nakayama Hideki , Satou Yorifumi 
Published: February 2025

ABSTRACTBackgroundVirus‐related cancers are malignancies caused by specific viruses, such as human papillomavirus (HPV), hepatitis B virus, and human T‐cell leukemia virus, contributing significantly to the global cancer burden through persistent infection and oncogenic transformation. The current study aimed to develop a robust HPV‐16 detection method for formalin‐fixed cancer specimens.Materials and MethodsTo prevent false negatives resulting from DNA fragmentation, a DNA quality check step was added. Additionally, this study used multiplex polymerase chain reaction (PCR) covering the entire HPV‐16 genome to mitigate effects caused by viral sequence variation. To prove this concept, we analyzed genomic DNA extracted from oropharyngeal cancer tissues known as HPV‐16‐positive. Subsequently, the protocol was tested on oral squamous cell carcinoma (OSCC) samples in our cohort. Given the wide variation in HPV‐16 positivity in previous studies, it remains elusive how frequently HPV‐16 is positive in OSCC.ResultsThe results showed faint bands or smears in the multiplex PCR of 7 out of 112 cases. Droplet digital PCR confirmed variable positivity levels of HPV‐16, suggesting two scenarios of HPV‐16 positivity in cancer tissue: cancer cells derived from infected cells or only a portion being HPV‐16‐positive. Finally, we comprehensively analyzed the case and identified the integration of a deleted HPV‐16 genome into the intronic region of the host gene TMEM94 on chromosome 17. To the best of our knowledge, this is the first evidence showing the integration of HPV‐16 in OSCC cells and providing its complete viral sequence.ConclusionsThe established protocol should be applicable to various cancer tissues for analyzing the association with HPV‐16 infection.
The Economic Burden of Colorectal Cancer in Type 2 Diabetes Mellitus (T2DM) in Shanghai, China
Authors: Zhu Zhi‐xu , Peng Yu‐xin , Ye Jing‐hong , Wei Yan 
Published: February 2025

ABSTRACTObjectiveThis study aimed to analyze disease cost levels among colorectal cancer (CRC) patients, examining differences in disease costs between those with type 2 diabetes mellitus (T2DM) and those without T2DM while considering various demographic characteristics.MethodsThe study included respondents from colorectal cancer patients diagnosed and managed within the population‐based cancer registry system of the Shanghai Municipal Center for Disease Control and Prevention from 2020 to 2022. Diabetic colorectal cancer cases were matched with nondiabetic colorectal cancer controls using propensity scores, maintaining a 1:1 ratio between cases and controls; bias for the majority of the matched variables is below 10%. Direct, indirect, and intangible costs were estimated for study subjects.ResultsAfter propensity score matching, the analysis encompassed 376 cases of T2DM‐related CRC and 376 non‐T2DM CRC cases. The T2DM group exhibited higher direct medical costs (¥57,059.65 vs. ¥48,933.93, p < 0.05), direct nonmedical costs (¥9292.45 vs. ¥7969.35), indirect costs (¥300.13 vs. ¥241.11), intangible costs (¥3601.70 vs. ¥2631.96), and total disease costs (¥70,253.93 vs. ¥59,776.36, p < 0.05) compared to the non‐T2DM group. In Stage II CRC, direct medical costs were ¥74,008.39 for the T2DM group versus ¥57,368.84 for the non‐T2DM group. Among surgical patients, direct medical costs were ¥57,658.81 for the T2DM group versus ¥1337.00 for the non‐T2DM group, and ¥49,061.52 for the non‐T2DM surgical group versus ¥1089.00 for the non‐T2DM nonsurgical group.ConclusionColorectal cancer imposes a substantial economic burden. Patients with CRC and concurrent T2DM experience a higher economic burden compared to nondiabetic patients. Notably, individuals with both T2DM and Stage II cancer face a significantly higher economic burden, whereas surgical patients exhibit a significantly greater disease burden than nonsurgical patients. Efforts should concentrate on primary prevention and secondary prevention to alleviate the economic burden associated with colorectal cancer.
Transcriptomic Profiles for Elucidating Response of Bladder Intracavitary Hyperthermic Perfusion Chemotherapy in High‐Risk Nonmuscular Invasive Bladder Cancer
Authors: Huang Zhicheng , Zhang Tianhui , Pan Jinghua , Zhang Guihao , Jiang Linjun , Jiang Huiming , Wan Pei , Peng Ying , Zou Wenchao , Liu Qinghua , Chen Nanhui 
Published: February 2025

ABSTRACTBackgroundBladder intracavitary hyperthermic perfusion chemotherapy (HIPEC) is a promising treatment for non‐muscular invasive bladder cancer (NMIBC). However, the molecular mechanisms underlying the response to HIPEC remain poorly understood. This study aimed to elucidate the transcriptomic profiles associated with the response to HIPEC in NMIBC patients.MethodsRNA sequencing was performed on bladder tumor samples from NMIBC patients who underwent HIPEC treatment. Differentially expressed genes (DEGs) between responders and non‐responders to HIPEC were identified. Gene ontology and pathway analysis were conducted to explore the biological functions and pathways enriched in the DEGs. Additionally, the expression of specific immune‐related genes was evaluated for their association with HIPEC response. The diagnostic efficiency of selected genes in predicting relapse before and after HIPEC treatment was assessed in a validation cohort.ResultsWe assessed the expression status of differentially expressed genes (DEGs) between responders and non‐responders to HIPEC. Gene ontology and pathway analysis revealed that DEGs were enriched in immune‐related pathways, including cytokine‐cytokine receptor interaction, chemokine signaling pathway, and antigen processing and presentation. Furthermore, the expression of several immune‐related genes, including ZMAP4, UPP2, and GALR1, was significantly associated with the response to HIPEC. Therefore, the immune system's reaction plays a crucial role in the response to HIPEC in patients with NMIBC. At last, a considerable diagnostic efficiency that tissue TMEFF2, KRT222, and GTSF1 in predicting relapse in NMIBC patients after HIPEC treatment, and ZMAP4, UPP2, and GALR1 in predicting relapse in NMIBC patients before HIPEC treatment in the validation cohort.ConclusionTranscriptomic profiling revealed that immune‐related pathways and genes play a crucial role in the response to HIPEC in NMIBC patients. These findings suggest that transcriptomic profiling could provide a valuable tool for predicting treatment outcomes and identifying therapeutic targets for NMIBC.
Successful Management of Aluminum Phosphide (Celphos) Poisoning With Aspiration Pneumonia: A Case Report
Authors: Kandel Rakshya Arun , Kafle Rukma Raj , Chaulagain Sabin , Shah Chandan , Atreya Alok 
Published: February 2025

ABSTRACTAluminum phosphide (AlP) poisoning typically has a poor prognosis, but this case report from Nepal demonstrated that prompt hospitalization, aggressive supportive care, including gastric lavage with coconut oil, and careful management of metabolic acidosis can lead to successful patient recovery.
Respiratory epithelial adenomatoid hamartoma, a different presentation
Authors: Fernandes Lopes Patrícia , Ruas Morgado Filipa , Canavarros Fernando , Santos Alberto , Macor Carlos 
Published: February 2025

Key Clinical MessageRespiratory epithelial adenomatoid hemartoma (REAH) has been included in the World Health Organization's classification of tumors since 2005. It results from non‐neoplastic overgrowth of glandular tissue. It is rarely located in the upper airway and in 70% of these cases it is present in the nasal septum. Within the described locations, it has never been described as attached to the nasal floor. We present the case of a 56‐year‐old male patient with progressive right nasal obstruction for 2 years. A nasal endoscopy showed a large, well circumscribed, whitish lesion with lobulated contour and solid polypoidal components. The incisional biopsy was inconclusive and the computed tomography (CT) of the paranasal sinuses showed obliteration of the right nostril and of the upper nasopharyngeal and oropharyngeal airways by a lobulated lesion. We performed endoscopic excision of the 9 cm lesion attached to the nasal floor. Histopathologic study revealed REAH. Of uncertain etiology, REAH appears to correlate with chronic inflammation. It presents with nonspecific symptoms, which may mimic other nasal lesions. Despite not being described in the literature, our case presented REAH located in the nasal floor. Only excisional biopsy determines the diagnosis. Treatment involves complete endoscopic excision. REAH are underdiagnosed and its identification is important to avoid more aggressive treatments. In this article we present a rare case of a REAH located in the nasal floor, not described in the literature to this date.
Aeroallergen sensitivity patterns in Gulf countries: A systematic review
Authors: Khurram Tahira , Missous Ghalia , van Panhuys Nicholas , Karim Mohammed Yousuf 
Published: February 2025

AbstractBackgroundSuccessful management of allergic diseases necessitates accurate diagnosis, implementation of appropriate allergen avoidance techniques, and medical therapies. However, data availability regarding aeroallergens in the Gulf Cooperation Council (GCC) countries is limited.MethodsWe conducted a systematic review of studies conducted in Gulf countries on individuals diagnosed with or tested for aeroallergen sensitivities, focusing on prevalence and respiratory health impacts. The search strategy followed the PRISMA guidelines and was conducted across PubMed, Scopus, Web of Science, and Google Scholar from inception to November 12, 2023.ResultsA total of 27 studies, both adult and pediatric, were included in this systematic review. Aeroallergen sensitization was assessed using skin prick testing (SPT) in 15 studies; 5 used in vitro methods, 2 employed both, 4 relied on self‐reports, and 1 on aerobiological monitoring. Sensitization rates varied considerably, influenced by factors such as age, demographics, and location. Sensitization was noted to allergens shared with Western populations, and to those native to the region for example, house dust mite sensitization ranged from 15% to 78%, Salsola from 13% to 78%. Up to 65.1% of allergen‐positive individuals demonstrated polysensitization. Sensitization patterns differed between indigenous populations and expatriates, with local allergens being more prevalent among natives. Sensitization rates were lower in younger children but increased with age.ConclusionOur systematic review highlights the crucial importance of providing allergen‐sensitivity information that is specifically tailored to the local environment. This tailored approach can improve clinical diagnosis, enable appropriate allergen avoidance and immunotherapy strategies, and result in potential cost savings.
Type 2 Diabetes Mellitus: A Comprehensive Review of Pathophysiology, Comorbidities, and Emerging Therapies
Authors: Singh Aditi , Shadangi Sucharita , Gupta Pulkit Kr. , Rana Soumendra 
Published: February 2025

ABSTRACTHumans are perhaps evolutionarily engineered to get deeply addicted to sugar, as it not only provides energy but also helps in storing fats, which helps in survival during starvation. Additionally, sugars (glucose and fructose) stimulate the feel‐good factor, as they trigger the secretion of serotonin and dopamine in the brain, associated with the reward sensation, uplifting the mood in general. However, when consumed in excess, it contributes to energy imbalance, weight gain, and obesity, leading to the onset of a complex metabolic disorder, generally referred to as diabetes. Type 2 diabetes mellitus (T2DM) is one of the most prevalent forms of diabetes, nearly affecting all age groups. T2DM is clinically diagnosed with a cardinal sign of chronic hyperglycemia (excessive sugar in the blood). Chronic hyperglycemia, coupled with dysfunctions of pancreatic β‐cells, insulin resistance, and immune inflammation, further exacerbate the pathology of T2DM. Uncontrolled T2DM, a major public health concern, also contributes significantly toward the onset and progression of several micro‐ and macrovascular diseases, such as diabetic retinopathy, nephropathy, neuropathy, atherosclerosis, and cardiovascular diseases, including cancer. The current review discusses the epidemiology, causative factors, pathophysiology, and associated comorbidities, including the existing and emerging therapies related to T2DM. It also provides a future roadmap for alternative drug discovery for the management of T2DM.
Identification of QTLs for reproductive stage salinity tolerance in rice using a cross between CSR28 and BRRI dhan28
Authors: Mondal Sejuti , Vaughn Robert , Septiningsih Endang M. , Singh Rakesh K. , Thomson Michael J. 
Published: February 2025

AbstractSalinity poses a serious threat to rice (Oryza sativa L.) production in coastal regions across the globe. Since salinity tolerance is a complex and polygenic trait, understanding the salt‐tolerance mechanisms is key for rice breeding. Breeding efforts can be aided by quantitative trait locus (QTL) mapping for complementary salt tolerance mechanisms in plants. While numerous studies are available on salinity tolerance at the seedling stage, limited studies have been conducted on reproductive stage tolerance in rice due to the difficulty in achieving reliable stage‐specific phenotyping techniques. In this study, a BC1F2 mapping population consisting of 435 individuals derived from a cross between a salt‐tolerant Indian variety, CSR28, and a salt‐sensitive Bangladeshi mega variety, BRRI dhan28, was evaluated for yield components after exposure to salinity stress of EC 10 dS/m during the reproductive stage. After selecting extremely tolerant and sensitive progenies, 190 individuals were genotyped by kompetitive allele‐specific PCR (KASP) genotyping with 152 high‐quality single nucleotide polymorphic (SNP) markers. Consequently, 15 QTLs were identified under reproductive stage salt stress, including plant height, panicle length, number of filled and unfilled spikelets, percent filled spikelets, grain yield, and the Na+‐K+ ratio. Notably, three QTLs, one each for the number of filled spikelets (qNFS10.1), percent filled spikelets (qPFS10.1), and grain yield (qGY10.1), were mapped at the same position (75.9 cM) on chromosome 10. These promising QTLs can be examined further to dissect the molecular mechanisms underlying reproductive stage salinity tolerance in rice.