bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and economic value of sofosbuvir-based regimens in the treatment of chronic hepatitis C in Spain
Authors: Esteban Rafael , Domínguez-Hernández Raquel , Martín-Escudero Victoria , Casado Miguel Ángel 
Published: December 2022

Background
The treatment of chronic hepatitis C virus (HCV) with direct-acting antivirals has undergone a spectacular revolution and added significant value to healthcare systems and patients. The aim of the study was to evaluate the efficiency and value of Sofosbuvir (SOF)-based regimens for a target population of 85,959 chronic HCV patients treated in Spain during 2015–2019, compared to previous therapeutic strategies (peginterferon/ and ribavirin in double/triple therapy with telaprevir or boceprevir).

Methods
A previously developed lifetime Markov model was adapted to simulate the disease HCV evolution. In SOF-based regimens, all patients (100%) were treated regardless with sustained virological response (SVR) of 93–98%, obtained from real-world data. In previous therapeutic, only ≥F2 patients were treated according to clinical practice (38%) with an average SVR of 61% taken from published literature. The value was measured as clinical and economic impact in terms of avoided HCV-related mortality and liver complications; total costs and quality-adjusted life years (QALYs) applying an annual 3% discount rate.

Results
Compared to previous therapeutic, during lifetime, SOF-based regimens reduced decompensated cirrhosis by 89%, hepatocellular carcinoma by 77% and liver transplant by 84%, decreasing the cost associated to liver complications management in €770 million. SOF-based regimens also decreased liver-related mortality by 82%. Besides, SOF-based regimens gained 310,765/QALYs, saving €274 million (considering drugs, monitoring, and HCV management).

Conclusion
For Spain, SOF-based regimens offer value for HCV patients in terms of lowering HCV-related liver disease burden and generating significant cost savings for the health system, contributing to the WHO goal.
Plotlands of Shepperton, Stefan Szczelkun (2020)
Silence!, Stefan Szczelkun (2020)
Authors: Baker Stephen 
Published: December 2022

Review of: Plotlands of Shepperton, Stefan Szczelkun (2020)
London: Working Press, 54 pp.,
ISBN 978-1-87073-624-4, p/bk, £12.95

Silence!, Stefan Szczelkun (2020)
London: Working Press, 84 pp.,
ISBN 978-1-87073-622-0, p/bk, £9.95
Environmental Concerns Associated with the Development of the Agro-Industrial Complex and Analysis of Its Financing
Authors: LUKPANOVA Zhanar , JUMABEKOVA Almagul , MUKUSHEV Abzal , MATAIBAYEVA Gulnar , KADRINOV Maulet , BAIMAGAMBETOVA Zamzagul 
Published: December 2022

The world's agriculture is transforming from a traditional to a high-tech industry that is able to create new markets for innovative and investment decisions and developments, striving to increase labor productivity and yields. Only advanced mechanized solutions can sometimes help to achieve significant results in this area, given the current problems, as well as the economic, environmental and social challenges facing the countryside.
The purpose of the study is to identify the environmental concerns associated with the development of the agro-industrial complex and the analysis of its financing in the Republic of Kazakhstan, as well as the creation of an environmentally oriented system for the utilization of agricultural waste.
Improving the Efficiency of the National Healthcare as Oriented Sustainable System. The Socio-Economic Aspects and Environmental Issues
Authors: SMAILOV Bakhytzhan , ANDAROVA Roza , AKYBAYEVA Gulvira , GORDEYEVA Yelena , MAMBETOVA Sagynysh , GELASHVILI Nikolay 
Published: December 2022

Based on a review of existing approaches, the article substantiates the nature of medical services as a mixed public good in relation with the sustainability of our society. In this regard, the typology of the modern healthcare sector is investigated on the basis of detailing the theoretical constructs underlying the applied models in response to their organizational mechanism.
It is established that the target of all applied models of organization of the healthcare system is to search for optimal productivity. Medical efficiency of healthcare generates organizational effectiveness of therapeutic measures, social efficiency – the accessibility to medical services, economic efficiency – resource efficiency, environmental efficiency – overall sustainability of the healthcare system.
The findings of this research outline that the ideal model of the healthcare system, besides the fact that should have a high medical, social and economic efficiency, should also be an environmentally oriented sustainable system which will allow healthy life also for the next generations.
Power hardware-in-the-loop testbeds for advances laboratory testing of smart grid applications
Authors: Spina Alfio , Rehtanz Christian 
Published: December 2022

Abstract
This paper assesses practical aspects related to advanced laboratory testing of smart grid applications with Power-Hardware-in-the-Loop (PHIL) approach. Particularly, the general features together with a set of extended use-cases for PHIL testing are introduced. An existing laboratory at TU Dortmund University is presented and considered as a reference for describing the architecture and the principal components of typical advanced laboratory testing infrastructures based on PHIL approach. A number of exemplary testbeds are provided to show the potentially applications of advanced PHIL testing for low-voltage distribution grids.
Shear strength and meso-pore characteristic of saturated compacted loess
Authors: Ma Jinlian , Zhong Xiumei , Wang Ping , Ye Shuaihua , Liu Fuqiang , Xu Xiaowei 
Published: December 2022

Abstract
With the increasing demand for filling engineering construction in the Loess Plateau, the engineering problems related to saturated loess caused by rainfall and irrigation are also increasingly prominent. This work studied the shear characteristics of saturated compacted loess by experiments, and qualitatively and quantitatively explained the meso-mechanism of the effect of compaction degree on the shear characteristics combined with the meso-pore characteristic parameters. The study shows that the stress–strain curve of saturated loess under 80 and 85% compaction degree is strain softening, it is strain weak softening under 90% compaction degree, and strain hardening under 95% compaction degree. The failure strength and pore water pressure have a good fitting linear relationship with compaction degree, and the fitting correlation coefficients are more than 0.97. Under 95% compaction degree, the pore water pressure increases with the development of axial strain, then decreases after the peak, and may appear negative. With the increase in compaction degree, the micro and small pore content of the saturated loess soil increases, the medium, large and super large pore content decreases, the proportion of pore area decreases, the pore shape becomes uniform and smooth, the complexity of pore shape decreases, the pore arrangement tends to be regular and neat, and the directionality increases. The research results can provide references for engineering design, construction, and numerical calculation of filling engineering in loess area.
Online Activities and Extremist Attitudes in Adolescence: An Empirical Analysis with a Gender Differentiation
Authors: Goede Laura-Romina , Schröder Carl Philipp , Lehmann Lena , Bliesener Thomas 
Published: December 2022

Abstract
Radicalization research is dedicated to analyzing factors related to radicalization processes, which in turn can lead to extremism. One factor is frequently discussed: the role of the Internet. This paper examines the relationship between active and passive online activities, including consumption, networking, and posting, and extremist attitudes in the field of Islamism and right-wing extremism among adolescents. Data from a school survey (N = 6,715) show that right-wing attitudes are particularly correlated with consumption of political websites, though this effect is weaker among females. However, posting shows only a small effect and networking shows no effect at all. Islamist attitudes, on the other hand, are related to the extent to which one consumes violent Islamist videos, meets other Muslims online, and posts Islamic content.
Synthesis, structure, and photocatalytic properties of a two-dimensional uranyl organic framework
Authors: Meng Yuning , Liu Donghui , Lan Qiaofa , Xie Ziyu , Niu Fei , Zhang Xiaolin , Yang Youming 
Published: December 2022

Abstract
A two-dimensional uranyl organic framework (UOF) UO2(L)(DMA) (1) (H2L = 2-aminoisophthalic acid, DMA = N, N-dimethylacetamide) has been solvothermally synthesized and characterized thoroughly by elemental analysis, infrared spectroscopy, single-crystal X-ray diffraction, solid fluorescence, powder X-ray diffraction, thermogravimetric analysis, and UV–visible spectroscopy. Furthermore, the degradation efficiencies of UOF 1 to organic dye methylene blue (MB) and rhodamine B (RhB) are 93.2 and 86.5% under irradiation of visible light which indicates that UOF 1 has remarkable photocatalytic activity. UOF 1 also displayed a certain selectivity for mixed dyes of MB & RhB.
Observaciones fenológicas, características del aceite e isoterma de equilibrio de las semillas de Myroxylon peruiferum (Fabaceae)
Authors: Aguilar-Sandí Diego , Solano-Quesada Guillermo , Vargas-Ramírez Ester , Monge-Vargas Andrés Antonio , Irías-Mata Andrea , Barboza-Barquero Luis 
Published: December 2022

Introducción. La información fenológica sobre Myroxylon peruiferum en Costa Rica es escasa. Además, se desconocen las características del aceite y la isoterma de equilibrio de las semillas.El conocimiento generado en este campo permitirá realizar un adecuado manejo de las semillas; y generar opciones de prospección del aceite. Objetivos. (i) Documentar un evento de floración y fructificación de un árbol de M. peruiferum. (ii) Determinar las características del aceite del fruto y la semilla. (iii) Generar una isoterma de absorción/des-absorción de agua. Materiales y métodos. De marzo a mayo de 2021, se documentó la floración y fructificación de un árbol de M. peruiferum en Montes de Oca, San José, Costa Rica. Los frutos maduros se recolectaron entre junio y julio. Se caracterizó el contenido de aceite de los frutos y de las semillas por separado. Se elaboró una isoterma de absorción/des-absorción de agua, con la que se probó el ajuste de la ecuación de Cromarty. Resultados. El periodo de floración, fructificación y dispersión duró cinco meses. Estas fenofases ocurrieron simultáneamente. El ácido oleico fue el principal ácido graso. Hubo una correlación significativa entre los porcentajes de ácidos grasos del aceite del fruto y el de la semilla, y entre los contenidos de ácidos grasos saturados, monoinsaturados y poliinsaturados. El aceite es amarillo, medianamente intenso y luminoso. Al incrementar la humedad relativa, el contenido de humedad de las semillas aumentó. La relación lineal entre los valores reales y los obtenidos mediante la ecuación de Cromarty fue de R2= 0,93. Conclusión. La recolección de frutos maduros puede realizarse entre marzo y agosto, y destinarlos a estudios de germinación, propagación y prospección del aceite. Ya establecida la relación entre la humedad relativa y contenido de humedad de la semilla, se pueden desarrollar estudios sobre almacenamiento de semillas y pérdida de viabilidad.
Toward a Faithful Contextualization
Authors: Martin Carlos G. 
Published: December 2022

When gospel and culture meet, is the message biblically faithful and culturally appropriate? A theology that begins with culture and where culture is the determining factor will unavoidably end in syncretism. Adventist theology does not start with the cultural context but with the biblical text. A valid approach to contextualization demands a commitment to biblical authority. The message of the Bible must not be compromised. In examining the topic of contextualization, this article first reviews the concepts of culture, a definition of contextualization itself, and the issue of syncretism. Then, it considers different approaches to the balance of Scripture and cultural setting, followed with a focus on the important issues of contextualization and culture, and contextualization and doctrines. In the two final sections, the article deals with implications for missions, evangelism, and pastoral ministry, and considers a faithful approach to contextualization.
Deciphering Students and Teachers' Perceptions Towards English as a Medium of Instruction: A Case Study of Prince Sattam Bin Abdulaziz University
Authors: Aldawsari Mohammed 
Published: December 2022

Medium of instruction has been shifting towards English, thereby producing English as a medium of instruction (EMI) in Saudi higher education due to internationalization, globalization, economic and technological advancement. Saudi universities have been adopting EMI to address the needs of the day and the demands by the stakeholders and students. This study explores the perceptions of Saudi university students and teachers about the use of EMI in the Saudi higher education. The participants are 80 students and 20 university teachers affiliated to Prince Sattam bin Abdulaziz University, Kingdom of Saudi Arabia. A five-point Likert-scale questionnaire was used to collect data. The findings show that both teachers and students hold positive perceptions about the use of EMI in Saudi universities. The findings suggest that teachers hold stronger positive attitudes towards the use of EMI. Students demonstrate a positive attitudinal behavior when teachers switch to Arabic while teaching. Findings further show that the use of EMI may hamper the native language and culture as perceived by the students. A number of implications have been suggested as students may feel hesitant to speak in English due to their low English proficiency.
Contested bodies and delayed decisions: Attitudes to COVID-19 vaccines among Jamaicans
Authors: Yasheva Smith Aieka 
Published: December 2022

El coronavirus de 2019 (covid-19) ha venido acompañado de numerosos factores que han afectado negativamente a los pequeños Estados insulares en desarrollo (PEID). A pesar de varias campañas de vacunación contra el covid-19 y del número de personas que han sufrido o han muerto por haber contraído el virus, muchos jamaicanos han retrasado su vacunación. Este estudio investiga los factores detrás de las actitudes de los jamaicanos hacia las vacunas contra el covid-19. Sus conclusiones se basan en el análisis del contenido de los periódicos jamaicanos (N = 200), incluyendo columnas, editoriales y noticias publicadas en las ediciones en línea de dos de las principales publicaciones del país (The Jamaica Gleaner y Jamaica Observer). El estudio concluye que son varios los factores que determinan la actitud de los jamaicanos hacia las vacunas covid-19, entre ellos se encuentran sus posibles efectos secundarios, la elección personal, la percepción de la pandemia, el insuficiente conocimiento sobre la eficacia de las vacunas, las creencias religiosas y la desconfianza en el gobierno jamaicano y las autoridades sanitarias. El estudio subraya que para los PEID, como Jamaica, que se caracterizan por tener economías frágiles y sistemas de atención sanitaria pública deficientes, la indecisión sobre las vacunas es un obstáculo potencial para superar algunos de los retos relacionados con la pandemia actual.
El estudio señala la necesidad crítica de mejorar la aceptación de la vacuna covid-19 entre los jamaicanos. La comprensión de las especificidades relativas a la indecisión en la vacunación permitirá al gobierno jamaicano y a los proveedores de atención sanitaria organizar mejor las campañas de sensibilización pública para abordar las preocupaciones de los no vacunados en Jamaica.
FAKTOR-FAKTOR MAHASISWA IPS DALAM MEMILIH PROGRAM STUDI DAN PENGARUHNYA TERHADAP PRESTASI BELAJAR
Authors: Husna Nisa Arifatul , Mustikawan Alfin 
Published: December 2022

This research has been motivated by one study program or selection obtained in higher education which results in learning achievement and lack of understanding of students with courses so that researchers are interested in examining this phenomenon because continuing higher education requires maturity in determining the choice to choose a campus and study program that has been developed. If desired, each election has its own reasons, both internally and externally. This study aims (1) to determine the most dominant factor influencing students in choosing social studies education study programs (2) to determine the effect of learning achievement among social studies education students based on the influencing factors. The research method is a quantitative approach, the type of exploratory and correlational research is the 2019 2020, 2021 student sample batch of 188 students. Questionnaire and documentation instruments, data analysis using validity and reliability tests, classical assumption test, factor analysis and hypothesis testing. The results of the study (1) the most dominant factors influencing students in choosing Social Science education study programs, internal factors of interest with a percentage of 28%, (2) the influence of student achievement in choosing study programs based on internal factors did not affect student achievement, while based on external factors have an effect on student achievement.
Abstrak
Penelitian ini telah dilatarbelakangi salah progam studi atau pemilihan yang didapat dalam perguruan tinggi yang mengakibatkan pada prestasi belajar dan kurangnya pemahaman mahasiswa dengan mata kuliah sehingga peneliti tertarik untuk meneliti fenomena tersebut karena melanjutkan keperguruan tinggi memerlukan kematangan dalam menentukan pilihan untuk memilih kampus serta progam studi yang telah diinginkan maka setiap pemilihan tersebut mempunyai alasan tersendiri baik secara internal maupun eksternal. Penelitian ini bertujuan (1) untuk mengetahui faktor yang paling dominan mempengaruhi mahasiswa dalam memilih prodi pendidikan IPS (2) untuk mengetahui pengaruh prestasi belajar antara mahasiswa pendidikan IPS berdasarkan faktor yang mempengaruhi. Metode penelitian pendekatan kuantitatif jenis penelitian eksploratif dan korelasional sampel mahasiswa angkatan 2019, 2020, 2021 berjumlah 188 mahasiswa. Instrumen kuisoner dan dokumentasi, analisis data menggunakan uji validitas dan reliabilitas, uji asumsi klasik, analisis faktor dan uji hipotesis. Hasil penelitian (1) faktor-faktor yang paling domina mempengaruhi mahasiswa dalam memilih prodi pendidikan ilmu Pengatahuan Sosial faktor internal i minat dengan hasil persentase 28%, (2) pengaruh prestasi belajar mahasiswa memilih prodi berdasarkan faktor internal tidak berpengaruh terhadap prestasi belajar mahasiswa, sedangkan berdasarkan faktor eksternal telah berpengaruh pada prestasi mahasiswa.
Pengaruh Pemberian Kalium dan Pembalikan Tanaman terhadap Pertumbuhan dan Produktivitas Ubi Jalar (Ipomoea batatas L.)
Authors: Rohmadani Rosyid , Anom Wijaya Ketut 
Published: December 2022

Ubi jalar merupakan salah satu tanaman pangan non biji yang dimanfaatkan umbinya sebagai sumber karbohidrat. Kebutuhan konsumsi ubi jalar setiap tahun mengalami peningkatan namun produksinya menurun. Upaya yang dapat dilakukan untuk meningkatkan produktivitas tanaman ubi jalar denan cara pemupukan dan teknik budidaya yang benar. Penelitian ini bertujuan untuk mengetahui dosis kombinasi dosis pupuk kalium dan frekuensi pembalikan tanaman yang sesuai untuk pertumbuhan dan produksi ubi jalar. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) 2 faktor yang terdiri dari dosis pupuk kalium K1= 150 kg/ha, K2= 200 kg/ha, K3=250 kg/ha dan K4=300 kg/ha sedangkan faktor kedua yaitu pembalikan tanaman P0= tanpa pembalikan, P1= pembalikan setiap 15 hari dan P2= pembalikan setiap 30 hari. Setiap perlakuan akan diulang sebanyak 3 kali sehingga jumlah keseluruhan terdapat 36 unit percobaan. Data yang diperoleh dianalisis dengan analisis sidik ragam (ANOVA). Hasil yang diperoleh selanjutnya diuji menggunakan Duncan Multiple Range Test (DMRT) taraf α 5% untuk membandingkan pengaruh antar perlakuan terhadap variabel pengamatan. Hasil penelitian menunjukkan pemberian dosis pupuk kalium dan pembalikan tanaman memberikan interaksi pada variabel diameter umbi, berat umbi per tanaman, berat umbi layak jual, berat rata-rata umbi dan produktivitas tanaman. Kombinasi perlakuan K3P1 memberikan hasil terbaik pada produktivitas tanaman dan lebih efisien didalam penggunaan pupuk, sedangkan perlakuan K4P2 menunjukkan hasil yang berbeda tidak nyata namun lebih efisien didalam tenaga kerja. Faktor tunggal dosis pupuk kalium 300 kg/ha menghasilkan panjang tanaman dan panjang umbi tertinggi. Faktor tunggal pembalikan tanaman setiap 15 hari (P1) mampu menghambat panjang tanaman, jumlah cabang dan ruas yang muncul akar adventif.
‘Talent Offends, Genius Terrifies’
Authors: Rontsch Marc 
Published: December 2022

Christopher Langford James (1952 – 2008) was a Zimbabwean-born composer, orchestrator and pianist, whose style conflated traditional European musical textures with southern African instrumentation, rhythms, and harmonies. His compositions include works such as Four Portraits for Pianoforte in Four Movements (1982), Songs of Lamentation and Remonstration (1985), Images of Africa (1987), and Paradise Regained (1999). While my research on James’s life and music has uncovered multiple angles for critical inquiry, the dominant narrative that emerged from interviews with his family, and discussions with colleagues, was that of mental illness.
This article argues that mental illness – while being a very real condition experienced by James – can simultaneously be understood as doing persona work. Through the intersecting frameworks of persona studies and life writing, this article critically interrogates the understanding of stereotypical concepts of mental illness within the construct of what Kim Barbour terms ‘artistness’. Through critical examination of how mental illness is understood and interpreted as a central construction of artistness, this article speaks to the complexity of the construction of James’s biography, and how the narrative performance of James’s mental illness can be understood within the framework of persona studies.