bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subjective cognitive complaints and dental clinic visits: A cross‐sectional study from the Japan Gerontological Evaluation Study
Authors: Yamamoto‐Kuramoto Kinumi , Kiuchi Sakura , Kusama Taro , Kondo Katsunori , Takeuchi Kenji , Osaka Ken , Aida Jun 
Published: August 2022

AimWe investigated the association between subjective cognitive complaints (SCCs) and dental visits in older Japanese adults.MethodsThis was a cross‐sectional study from the Japan Gerontological Evaluation Study (carried out in 2019). The participants were independent older adults aged ≥65 years without dementia. The presence/absence of dental treatment visits and dental checkup visits within the past 12 months were used as outcome variables. The SCC score measured using the Kihon Checklist was set as the explanatory variable. Possible confounders were also included as covariates. Prevalence ratios and 95% confidence intervals were estimated using a Poisson regression model.ResultsThe mean age was 74.1 years (standard deviation 6.0 years). Among the 19 677 eligible participants, 12 359 (62.8%) had dental treatment visits and 11 063 (56.3%) had dental checkup visits. Of these, 5966 (30.3%) had an SCC score of ≥1. The proportion of participants with dental treatment and dental checkup visits within the past 12 months was 63.2% and 56.7% among those with SCC score = 0, and 52.8% and 35.2% among those with SCC score = 3, respectively. In the fully adjusted model, no significant association was observed for participants with SCC scores of 1 and 2. Those with SCC score = 3 had less frequent dental checkup visits (prevalence ratio 0.74, 95% confidence interval 0.57–0.95).ConclusionsOur study highlights that SCC was not associated with limited access to dental care among those with mild SCC. However, those with the highest SCC score seemed to have disturbed access to dental care. Geriatr Gerontol Int 2022; 22: 773–778.
The evolutionary patterns of intercity co‐invention networks in the Greater Pearl River Delta, China: A comparative analysis based on the technological intensity of industry
Authors: Chong Zhao‐hui , Liu Jia 
Published: August 2022

AbstractA substantial amount of research has examined the collaborations within technology‐based industries, but how technological intensity relates to the evolution of interregional research collaboration is less well understood. This paper investigates the dynamic changes of spatial structure and determinants of intercity research collaborations in the sectoral innovation networks of high‐tech industries contrasting to low and medium technology (LMT) industries in the Greater Pearl River Delta (GPRD), China. Using the sectoral patent application data over the period 2008–2016, the social network analysis results confirm a higher level of triangles in the co‐invention network of high‐tech industries than within LMT industries. Moreover, the empirical results through Exponential Random Graph Model (ERGM) show that, compared to LMT industries, collaboration in the co‐invention network of high‐tech industries is less sensitive to geographical and linguistic distance, while more subject to economic distance, regional educational level and government support with time. In addition, cognitive proximity and regional R&D intensity are both important prerequisite in the formation of these two collaborative networks.
Institutional varieties, governance quality, and firm‐level innovation in emerging economies: Case of India
Authors: Persaud Ajax , Zare Javid 
Published: August 2022

AbstractThis study examines how institutional varieties at the subnational (state) level influence firm‐level innovation in an emerging economy—India. Knowledge of how institutional varieties influence firm‐level innovation is derived principally from country‐level studies involving multiple developed countries. Research on emerging economies is sparse and tends to follow country‐level approaches involving multiple countries. Research involving asingleemerging economy where there are substantial institutional varieties between regions is thin. The institutional varieties of some emerging countries are so striking that they can be viewed as several countries within a country, for example, India, China. This study contributes to the innovation literature on the role of institutional varieties on firm‐level innovation by focusing on a different level of analysis—a single, emerging economy with substantial institutional varieties across the different states of India. Innovation in emerging economies is a topic of increasing academic interest. A multilevel study involving regional‐ and firm‐level factors is employed. Firm‐level data are from the World Bank Enterprise Survey and regional‐level data are from statistical agencies in India. The results confirm that institutional varieties have major impacts on firm‐level innovation. The research, policy, and managerial implications are discussed.
Switching from standard to extended half‐life FVIII prophylaxis in haemophilia A: Comparison of factor product use, bleed rates and pharmacokinetics
Authors: Nummi Vuokko , Lehtinen Anna‐Elina , Iorio Alfonso , Szanto Timea , Lassila Riitta 
Published: August 2022

AbstractIntroductionMajority of haemophilia A patients in our comprehensive care centre have switched from standard half‐life (SHL) to extended half‐life (EHL) FVIII products in a short time.AimWe compared the clinical and laboratory outcomes between SHL and EHL FVIII prophylaxis in product switchers.MethodsThis is a retrospective inception cohort of all adult haemophilia A patients switched to EHL (rFVIIIFc or rFVIII‐PEG) prophylaxis in our centre. Dosing, product utilization, annualized bleed rates (ABR), treatment regimen and pharmacokinetics by Web Accessible Population Pharmacokinetic Service (WAPPS)‐Hemo were compared between SHL and EHL.ResultsWe included 38 patients, whose median age was 38 years (range 17–75). Median FVIII dose was 23 IU/kg for SHL versus 25 IU/kg for EHL. After switching, weekly infusions decreased by 29% from median 2.8 (every 2.5 days) to 2.0 (every 3.5 days) (P = <.001) and factor consumption for prophylaxis by 17% from 60 to 50 IU/kg/week (P = <.001). Weekly infusions decreased in 71% and FVIII utilization in 55% of patients. ABR remained low (1.0 for SHL and .5 for EHL, respectively). In pharmacokinetics, the half‐life of FVIII increased from median 13 to 21 h after switching. Times above .01 and .03 IU/ml improved from 85 to 131 h and from 65 to 106 h. Half‐lives of the SHL products and von Willebrand factor levels predicted half‐lives with the EHL products.ConclusionsOur cohort study confirms the successful experience of switching to EHL FVIII products, with decreased infusion frequency, factor consumption and excellent clinical efficacy.
Antibiotic resistance status of helicobacter pylori strains isolated from initial eradication patients in Ningbo, China, from 2017 to 2021
Authors: Shao Yongfu , Lin Yifan , Wang Bojun , Miao Min , Ye Guoliang 
Published: August 2022

AbstractBackgroundResistance of Helicobacter pylori (H. pylori) to antibiotics is an evolving and dynamic process. Presence of antibiotic resistance impacts the success rate of initial eradication strategies in the clinic.AimTo improve the success rate of initial eradication therapy and explore new antibiotic regimens, a large sample‐based study utilizing antimicrobial susceptibility testing was performed. A total of 2508 H. pylori strains from patients subjected to initial eradication therapy were isolated, cultured, and tested for drug susceptibility from 2017 to 2021. The minimal inhibitory concentration (MIC) was recorded. H. pylori susceptibility profiles and its change trends from initial eradication patients were analyzed. The relationships between drug resistance, year of sample collection, age, and sex of patients were analyzed.ResultsThe overall resistance rates were as follows: amoxicillin (9.25%), clarithromycin (38.48%), levofloxacin (42.86%), furazolidone (11.28%), doxycycline (8.56%), rifampicin (10.81%), tinidazole (74.32%), gatifloxacin (61.71%), tetracycline (0%), metronidazole (78.71%), ornidazole (97.87%), and fosfomycin (31.67%). Only 38.04% of the strains were pansusceptible to amoxicillin, clarithromycin, levofloxacin, and furazolidone, followed by those of mono resistance (29.90%), double resistance (24.96%), triple resistance (6.34%), and quadruple resistance (0.76%). Significant differences in the resistance rate and MIC were also observed in different age and sex groups. Time of collection and patient age and sex were associated with the distribution of antibiotic resistance.ConclusionWith the increasing resistance rate and multiple resistance of H. pylori to commonly used antibiotics, drug susceptibility testing is imperative to permit individualized therapy, and a regimen containing the combination of amoxicillin, furazolidone, tetracycline, doxycycline, or rifampicin is reasonable for initial empirical eradication therapy.
Helicobacter pyloriresults in lysis and death after exposure to water
Authors: Inamasu Yoshinori , Ogawa Midori , Saito Mitsumasa , Harada Masaru , Fukuda Kazumasa 
Published: August 2022

AbstractBackgroundHelicobacter pylorihas a high infection rate, and it is possible that more than half of the world's population is infected. The route of transmission ofH. pylorihas not been completely elucidated yet. The coccoid form ofH. pyloriis generally considered to be in a VBNC (viable but nonculturable) state, and this form in the environment is thought to play an important role in infection and transmission, but its stability and survivability are still unknown.Materials and methodsIn order to promote its changing to coccoid form, the spiral form ofH. pylorigrown in a culture medium was exposed to sterile distilled water, and we investigated the bacterial cell number and the morphological changes by using fluorescence staining methods and electron microscopic observation. We also examined the dynamics of its growth ability by measuring the colony forming unit on an agar‐plate medium.ResultsAfter exposure to sterile distilled water, theH. pylorispiral form rapidly lost its growth ability at 37°C. One day after exposure, approximately 95% of the spiral form disappeared and the proportion of the coccoid form increased. The total number of bacteria also decreased to less than half and continued to decrease over time. Epi‐microscopic and electron microscopic observations revealed that deformation of bacterial cells, collapse, and leaking out of cell contents were promoted in exposure to sterile distilled water.ConclusionHelicobacter pyloriquickly begins to transform into the coccoid form after exposure to sterile distilled water, rapidly loses its growth ability, and then lyses and dies. Water‐exposure is lethal forH. pyloriand it is unlikely to survive in the VBNC state in water.
Global crisis management and higher education: Agency and coupling in the context of wicked COVID‐19 problems
Authors: Oleksiyenko Anatoly , Mendoza Pilar , Riaño Fredy Esteban Cárdenas , Dwivedi Om Prakash , Kabir Arif H. , Kuzhabekova Aliya , Charles Muweesi , Ros Vutha , Shchepetylnykova Ielyzaveta 
Published: August 2022

AbstractCampus crisis management remains an understudied topic in the context of COVID‐affected higher education. In this paper, we contrasted the ability to tame the wicked problems brought by the pandemic of COVID‐19 in private and public universities in Bangladesh, Cambodia, Colombia, India, Kazakhstan, Uganda, and Ukraine. The cross‐country analysis and diversity of institutional types allowed us to consider a wide range of challenges faced by academic leaders and their institutions during the global pandemic. By drawing on institutional policy reviews and interviews with university administrators, we have examined tensions between the human and institutional agencies on these crisis‐stricken campuses given differing institutional coupling, sizes, resources, and missions. The focus on agential co‐dependencies and institutional coupling lays the ground for conceptualizing campus crisis management as a culturally specific construct in the context of higher education affected by the global pandemic.
Use of contraindicated antiretroviral drugs in people with HIV/HCV coinfections receiving HCV treatment with direct‐acting antivirals—Results from the EuroSIDA study
Authors: Nikolaichuk Myroslava , Mocroft Amanda , Wandeler Gilles , Szlavik János , Gottfredsson Magnus , Reikvam Dag Henrik , Svedhem Veronica , Elinav Hila , Laguno Montserrat , Mansinho Kamal , Devitt Emma , Chkhartishvili Nikoloz , Behrens Georg , Bogner Johannes , Viard Jean‐Paul , Winston Alan , Benfield Thomas , Leen Clifford , Fursa Olga , Rockstroh Jürgen , Peters Lars ,   for the EuroSIDA study group
Published: August 2022

AbstractObjectivesOur objective was to determine whether antiretroviral drugs (ARVs) were used according to the European AIDS Clinical Society (EACS) guidelines for people with HIV/hepatitis C virus (HCV) coinfection treated with direct‐acting antivirals (DAAs) between 30 November 2014 and 31 December 2019 in the pan‐European EuroSIDA study.MethodsAt each publication date of the EACS guidelines, plus 3 and 6 months, we calculated the number of people receiving DAAs with potential and actual ARV contraindications (‘red shading’ in the EACS guidelines). We used logistic regression to investigate factors associated with using contraindicated ARVs.ResultsAmong 1406 people starting DAAs, the median age was 51 years, 75% were male, 57% reported injected drug use as an HIV risk, and 76% were from western Europe. Of 1624 treatment episodes, 609 (37.5%) occurred while the patient was receiving ARVs with potential contraindications; among them, 38 (6.2%; 95% confidence interval [CI] 4.3–8.2) involved a contraindicated ARV (18 non‐nucleoside reverse transcriptase inhibitors), 16 involved protease inhibitors, and four involved integrase strand transfer inhibitors. The adjusted odds of receiving a contraindicated ARV were higher (3.25; 95% CI 1.40–7.57) among participants from east/central east Europe (vs. south) and lower (0.22; 95% CI 0.08–0.65) for 2015–2018 guidelines (vs. 2014). In total, 29 of the 32 (90.6%) patients receiving a contraindicated ARV and 441 of the 461 (95.7%) with potential ARV contraindications experienced a sustained virological response ≥12 weeks after stopping treatment (SVR12; p = 0.55).ConclusionIn this large heterogenous European cohort, more than one‐third of people with HIV/HCV coinfection received DAAs with potential ARV contraindications, but few received a contraindicated ARV. Use of contraindicated ARVs declined over time, corresponding to the increased availability of ARV therapy regimens without interactions with DAA across Europe. Participants who received a contraindicated DAA and ARV combination still had a high rate of SVR12.
Efficacy, durability, and tolerability of dolutegravir/lamivudine and dolutegravir/rilpivirine for the treatment of HIV in a real‐world setting in Belgium
Authors: Nasreddine Rakan , Yombi Jean Cyr , Darcis Gilles , Florence Eric , Allard Sabine D. , De Scheerder Marie‐Angélique , Henrard Sophie , Demeester Rémy , Messiaen Peter , Ausselet Nathalie , Loeckx Matthias , Delforge Marc , De Wit Stéphane ,   the Belgian Research on AIDS and HIV Consortium (BREACH)
Published: August 2022

AbstractObjectivesA paradigm shift from three‐drug regimens to two‐drug regimens (2DRs) is currently taking place in real‐world clinical practice. This study aimed to describe the efficacy, durability, and tolerability of dolutegravir (DTG)/lamivudine (3TC) and DTG/rilpivirine (RPV) in a real‐world setting.MethodsThis was a retrospective, observational, multicentre (ten centres in Belgium) study involving adult treatment‐naïve and treatment‐experienced people living with HIV on DTG/3TC or DTG/RPV between 1 January 2019 and 30 September 2020. The primary endpoint was rate of virological suppression (VS; plasma HIV‐1 viral load [VL] <50 copies/ml) using an on‐treatment analysis. Main secondary endpoints included the proportion of people that experienced loss of VS (LVS; defined as two consecutive HIV‐1 VLs of >200 copies/ml after initially achieving VS) and a resistance analysis at the time of LVS; rate, incidence, and reasons for discontinuation of treatment (stopping treatment or changing any component of the 2DR); and change in weight, along with the proportion of people reporting a >10% weight gain. Ordinal logistic regression analysis examined associations between baseline variables and >10% on‐treatment weight gain.ResultsOverall, 948 people were included, of whom 734 (77%) were on DTG/3TC and 214 (23%) were on DTG/RPV. Baseline characteristics included 54% aged ≥50 years, 31% female, 31% Black sub‐Saharan African, 95% treatment‐experienced, and 8% with HIV‐1 VL ≥50 copies/ml. Through 48 weeks, the rate of VS for the overall cohort was 98.3% (99.1% with 3TC; 96.2% with RPV). LVS was observed in 0.5% (n = 5) of the overall population (n = 1 [3TC group], n = 4 [RPV group]). There were 40 treatment discontinuations (4.2%, n = 27 [3TC group]; n = 13 [RPV group]), corresponding to an incidence of 4.7 per 100 patient‐years. The most common reason for discontinuation was an adverse event (1.4%), with neurotoxicity the most frequent (0.5%). Median on‐treatment weight gain at week 48 was 1 kg (interquartile range [IQR] −1–3) overall, 1 kg (IQR −1–3) in the 3TC group, and 2 kg (IQR 0–4) in the RPV group. A >10% weight increase was observed in 6.3% of people. Regression analysis showed that being on a tenofovir disoproxil fumarate‐based regimen prior to 2DR initiation was the only variable associated with a >10% increase in weight from baseline (odds ratio 3.48; 95% confidence interval 1.13–10.68; p = 0.038).ConclusionIn this real‐world analysis, the 2DRs analysed were effective, durable, and safe for those who were treatment‐naive and treatment‐experienced. A slight increase in weight was associated with these regimens.
Thermoelectric properties of a series of polycrystalline Mo(Se1−xTex)2
Authors: Park Okmin , Kim Hyun‐Sik , Lee Se Woong , Lee You Jong , Park Sang Jeong , Kim Sang‐il 
Published: August 2022

AbstractTransition metal dichalcogenides have being actively studied on the account of their large density‐of‐state effective mass and low lattice thermal conductivity. Herein, thermoelectric and electrical transport properties of MoSe2–MoTe2 system are investigated. A series of Mo(Se1−xTex)2 (x = 0, .25, .5, .75, and 1) polycrystalline samples was synthesized by conventional solid‐state reaction. Single hexagonal phase was identified for each sample without secondary phase, confirming the formation of complete solid solutions between MoSe2 and MoTe2. The electrical conductivity and magnitude of the Seebeck coefficient increased simultaneously with increasing Te content x at high temperatures, with the power factor following the same trend. As results, the MoTe2 sample exhibited the maximum power factor of .014 mW/(m K2) at 823 K. The lattice thermal conductivities of the alloyed samples (x = .25, .5, and .75) significantly decreased compared to MoSe2 and MoTe2 owing to point defect phonon scattering via anion substitution, which is verified by the Debye–Callaway model. A maximum zT of .0044 was obtained for MoTe2 sample at 773 K; however, the calculated quality factor B values of the samples with x = .75 and 1 at 773 K were almost identical, suggesting that a further enhancement of zT can be achieved by optimizing an nH of the Mo(Se0.25Te0.75)2 sample.
The influence of emotional burnout and resilience on the psychological distress of nursing students during the COVID‐19 pandemic
Authors: Merino‐Godoy María Ángeles , Yot‐Domínguez Carmen , Conde‐Jiménez Jesús , Ramírez Martín Patricia , Lunar‐Valle Piedad María 
Published: August 2022

AbstractThe aim of this study was to measure and analyse the association of emotional burnout and resilience with the psychological distress of students who finished their nursing studies after the peak of the COVID‐19 pandemic. The mental health of nursing students was affected during the pandemic, and resilience seems to counteract the negative effects. This is a cross‐sectional study. The data (quantitative) were gathered at the beginning of the second term of the academic year 2020/2021. The study was carried out in the Spanish university context. Self‐reported measures were gathered using three one‐dimensional, valid, and reliable scales: the Psychological Distress Scale (K‐10), the Emotional Burnout Scale (EBS), and the short version of the Connor‐Davidson Resilience Scale (CD‐RISC10). A total of 393 students of different Spanish universities participated in this study. A valid linear regression model was obtained, which allowed verifying that psychological distress is explained, with 37% variance, by emotional burnout and resilience. The total score in emotional burnout has more relevance than the total score in resilience, and the latter has a negative tendency. Facing the factors that generate emotional burnout in students in the academic scope and promoting resilience in them are fundamental aspects that contribute to their psychological well‐being. The reflection should be extended to clinical practices. Universities are urged to think about last‐year students, their experiences, perceptions, and feelings, to determine how their susceptibility to emotional burnout and psychological distress can be minimized in their future clinical practices. Strategies to promote their resilience should also be studied.
The impact of trauma‐informed suicide prevention approaches: A systematic review of evidence across the lifespan
Authors: Procter Nicholas , Othman Shwikar , Jayasekara Rasika , Procter Alexandra , McIntyre Heather , Ferguson Monika 
Published: August 2022

AbstractTrauma is associated with an increased likelihood of experiencing suicidality, indicating the need for and potential value of trauma‐informed suicide prevention strategies. The aim of this study is to systematically review published literature regarding trauma‐informed approaches for suicide prevention, and the impact on suicide outcomes. Systematic searches were conducted in eight databases (Medline, Embase, PsycInfo, Emcare, Nursing, and JBI in the Ovid platform; as well as ProQuest Psychology Database and The Cochrane Library) in March 2022, with no publication date limit. Four studies met the inclusion criteria: two randomized controlled trials and two quasi‐experimental studies. Two studies reported reductions in ideation, intent, and behaviour among youth and a cultural minority group. Few studies directly reporting suicide outcomes were identified, all were quantitative, and heterogeneity prevents generalizability across population groups. Currently, there is limited evidence focusing specifically on trauma‐informed suicide prevention across the lifespan. Additional research, incorporating lived experience voices, is needed to understand the potential of this approach, as well as how mental health nurses can incorporate these approaches into their practice.