bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-time fathers show longitudinal gray matter cortical volume reductions: evidence from two international samples
Authors: Martínez-García Magdalena , Paternina-Die María , Cardenas Sofia I , Vilarroya Oscar , Desco Manuel , Carmona Susanna , Saxbe Darby E 
Published: September 2022

AbstractEmerging evidence points to the transition to parenthood as a critical window for adult neural plasticity. Studying fathers offers a unique opportunity to explore how parenting experience can shape the human brain when pregnancy is not directly experienced. Yet very few studies have examined the neuroanatomic adaptations of men transitioning into fatherhood. The present study reports on an international collaboration between two laboratories, one in Spain and the other in California (United States), that have prospectively collected structural neuroimaging data in 20 expectant fathers before and after the birth of their first child. The Spanish sample also included a control group of 17 childless men. We tested whether the transition into fatherhood entailed anatomical changes in brain cortical volume, thickness, and area, and subcortical volumes. We found overlapping trends of cortical volume reductions within the default mode network and visual networks and preservation of subcortical structures across both samples of first-time fathers, which persisted after controlling for fathers’ and children’s age at the postnatal scan. This study provides convergent evidence for cortical structural changes in fathers, supporting the possibility that the transition to fatherhood may represent a meaningful window of experience-induced structural neuroplasticity in males.
Renal involvement is frequent in adults with primary mitochondrial disorders: an observational study
Authors: Bakis Hugo , Trimouille Aurélien , Vermorel Agathe , Goizet Cyril , Belaroussi Yaniss , Schutz Sacha , Solé Guilhem , Combe Christian , Martin-Negrier Marie-Laure , Rigothier Claire 
Published: September 2022

ABSTRACT

Background
Mitochondrial functions are controlled by genes of both mitochondrial and nuclear DNA. Pathogenic variants affecting any of these are responsible for primary mitochondrial disorders (MIDs), which can be diagnosed during adulthood. Kidney functions are highly dependent on mitochondrial respiration. However, the prevalence of MID-associated nephropathies (MIDANs) is unknown in the adult population. We aimed to address this point and to provide a full characterization of MIDANs in this population.

Methods
We retrospectively included for observational study adults (≥16 years of age) with genetically diagnosed MID between 2000 and 2020 in our tertiary care academic centre when they had a chronic kidney disease (CKD) evaluation. MIDANs were ascertained by CKD occurring in MIDs. The phenotypic, biological, histopathological and genotypic characteristics were recorded from the medical charts.

Results
We included 80 MID-affected adults and ascertained MIDANs in 28/80 (35%). Kidney diseases under the care of a nephrologist occurred in only 14/28 (50%) of the adults with MIDAN. MIDANs were tubulointerstitial nephropathy in 14/28 patients (50%) and glomerular diseases in 9/28 (32.1%). In adults with MID, MIDAN was negatively associated with higher albumin levels {odds ratio [OR] 0.79 [95% confidence interval (CI) 0.67–0.95]} and vision abnormalities [OR 0.17 (95% CI 0.03–0.94)] and positively associated with hypertension [OR 4.23 (95% CI 1.04–17.17)].

Conclusion
MIDANs are frequent among adult MIDs. They are mostly represented by tubulointerstitial nephropathy or glomerular disease. Vision abnormalities, hypertension and albumin levels were independently associated with MIDANs. Our results pave the way for prospective studies investigating the prevalence of MIDANs among undetermined kidney disease populations.
Deep immune profiling of patients with renal impairment unveils distinct immunotypes associated with disease severity
Authors: Wu I-Wen , Wu Yi-Lun , Yang Huang-Yu , Hsu Cheng-Kai , Chang Lun-Ching , Twu Yuh-Ching , Chang Ya-Ling , Chung Wen-Hung , Yang Chih-Wei , Hsieh Wen-Ping , Su Shih-Chi 
Published: September 2022

ABSTRACT

Background
Chronic kidney disease (CKD) is pathologically correlated with a sophisticated milieu of innate and adaptive immune dysregulation, but the underlying immunological disturbances remain poorly understood.

Methods
To address this, we comprehensively interrogated cellular and soluble elements of the immune system by using high-dimensional flow cytometry to analyze peripheral blood mononuclear cells and performing cytokine/chemokine profiling of serum samples, respectively, in a cohort of 69 patients and 19 non-CKD controls.

Results
Altered serum levels of several cytokines/chemokines were identified, among which concentrations of stem cell factor (SCF) were found to be elevated with the progression of CKD and inversely correlated with estimated glomerular filtration rate (eGFR). Deep immunophenotyping analyses reveal a global change in immune modulation associated with CKD severity. Specifically, a decrease in the subsets of CD56dim natural killer (NK) cells (KLRG-1+CD38+CD64+CD15+CD197+) and monocytes (KLRG-1+CD38+PD-1+) was detected in severe CKD compared with controls and mild CKD. In addition, comparisons between mild and severe CKD demonstrated a loss of a mature B cell population (PD-1+CD197+IgD+HLA-DR+) in the advanced stages of disease. Further, we identified immunophenotypic markers to discriminate mild CKD from the controls, among which the portion of CD38+ monocytes was of particular value in early diagnosis.

Conclusions
Our data unveil severity-specific immunological signatures perturbed in CKD patients.
Thiazide diuretics are back in CKD: the case of chlorthalidone
Authors: Minutolo Roberto , De Nicola Luca , Mallamaci Francesca , Zoccali Carmine 
Published: September 2022

ABSTRACT
Sodium and volume excess is the fundamental risk factor underlying hypertension in chronic kidney disease (CKD) patients, who represent the prototypical population characterized by salt-sensitive hypertension. Low salt diets and diuretics constitute the centrepiece for blood pressure control in CKD. In patients with CKD stage 4, loop diuretics are generally preferred to thiazides. Furthermore, thiazide diuretics have long been held as being of limited efficacy in this population. In this review, by systematically appraising published randomized trials of thiazides in CKD, we show that this class of drugs may be useful even among people with advanced CKD. Thiazides cause a negative sodium balance and reduce body fluids by 1–2 l within the first 2–4 weeks and these effects go along with improvement in hypertension control. The recent CLICK trial has documented the antihypertensive efficacy of chlorthalidone, a long-acting thiazide-like diuretic, in stage 4 CKD patients with poorly controlled hypertension. Overall, chlorthalidone use could be considered in patients with treatment-resistant hypertension when spironolactone cannot be administered or must be withdrawn due to side effects. Hyponatremia, hypokalaemia, volume depletion and acute kidney injury are side effects that demand a vigilant attitude by physicians prescribing these drugs. Well-powered randomized trials assessing hard outcomes are still necessary to more confidently recommend the use of these drugs in advanced CKD.
Firm Ex Ante Heterogeneity, Entry and the Labour Share
Authors: Grazzini Jakob , Rossi Lorenza 
Published: September 2022

Abstract
This paper considers a two-sector real business cycle model augmented with firm heterogeneity and firm dynamics, and studies the steady state and dynamic properties of the model in response to a decline in the relative price of investment. It shows that both firm heterogeneity and entry play a crucial role in the decline in the labour share and the increase in capital intensity observed in the US economy. Using ORBIS firm-level data of the US economy, the paper finds robust evidence consistent with the mechanisms described in the model.
Populist Persuasion in Electoral Campaigns: Evidence from Bryan's Unique Whistle-Stop Tour
Authors: Buggle Johannes C , Vlachos Stephanos 
Published: September 2022

Abstract
This paper examines the effect of campaign appearances in the context of the one-sided nationwide tour by William J. Bryan, the Democratic US presidential candidate in 1896. During this electoral campaign, Bryan undertook an unprecedented whistle-stop train tour, while the Republican candidate followed a front-porch campaign. To identify the causal effect of campaign speeches, we exploit several estimation strategies, including a within-county difference-in-differences design and a neighbour-pair fixed effect estimator. We find that campaign visits by Bryan increased his vote share by about one percentage point on average. This increase likely stems from the persuasion of previously non-aligned industrial workers.
Development and Validation of a Modified QuEChERS Method for Simultaneous Analysis of 250 Flavor Constituents in Tobacco by Gas Chromatography Tandem Mass Spectrometry
Authors: Chen Li , Shi Tiancai , Zhao Jiaxing , Ren Zongcan , Cui Huapeng , Xie Fuwei , Fan Meijuan , Liu Shaofeng , Nie Cong , Liu Huimin 
Published: September 2022

Abstract

Background
Flavor constituents play an important role in the flavor characteristics of tobacco leaves and cigarettes. Sensitive, selective, and high-throughput multi-analyte analytical methods are needed to satisfy the demand for analyzing trace-level flavor constituents in tobacco. However, trace analysis of multi-targets in a complex tobacco matrix is significantly challenging.

Objective
This study was undertaken to develop and validate a fast, selective, sensitive, and accurate GC–tandem mass spectrometry (GC–MS/MS) method for the simultaneous analysis of 250 flavor constituents in tobacco using a modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) extraction procedure and backflushing technique.

Methods
The samples were extracted with a mixture of acetonitrile and phosphate buffer. GC–MS/MS served as a reliable tool to quantify the flavor constituents due to its high sensitivity, selectivity, and good repeatability.

Results
Our evaluation showed that 243 flavor constituents presented good linearity. Average recoveries of 216 target compounds in tobacco ranged from 70 to 120% with RSDs less than 20% at three fortification levels. The limits of quantitation of 225 and 25 compounds were in the range of 2–50 and 51–112 μg/kg, respectively. This method was then successfully applied to the analysis of 15 commercial cigarette samples with different style characteristics.

Conclusion
The modified QuEChERS method worked very well for a wide range of flavor constituents that have not been reported by QuEChERS pretreatment previously, and the use of concurrent backflushing offered significant increase in system robustness and sample throughput. The method greatly improved the detection performance and the range of the flavor constituents, and proved to be more accurate, sensitive, selective, convenient, and practical than the reported method, and thus, can be applied in routine analysis.

Highlights
A validated QuEChERS-based GC–MS/MS method for multiple flavor constituents analysis in tobacco was reported for the first time. The use of concurrent backflushing markedly improved the instrument robustness and sample throughput.
Clinical Toxicological Follow-Up Analysis of a Suicide Attempt Using Chloroquine
Authors: Jacobs Cathy M , Wagmann Lea , Frankenfeld Fabian , Meyer Markus R 
Published: September 2022

AbstractChloroquine, a drug approved for the treatment of malaria, is frequently used to commit suicide. We report about a suicide attempt by ingesting a high dose of chloroquine in combination with other drugs. Findings of the emergency toxicology screening of blood and urine and those of the follow-up analyses in blood are discussed. Systematic toxicological analysis approaches revealed the presence of chloroquine, butylscopolamine, cafedrine, diazepam, lorazepam, metoclopramide, nordazepam, norephedrine and 11-nor-9-carboxy-∆9-tetrahydroxycannabinol in blood and/or urine of the subject. Suicide due to a combination of chloroquine and benzodiazepines is known as the so-called “Kusch method” in German-speaking countries. The initial chloroquine plasma concentration was determined to be 9.6 mg/L after precipitation and analysis by liquid chromatography–high-resolution tandem mass spectrometry. The analytical procedure was developed ad hoc and validated in accordance with international recommendations. Clinical toxicological follow-up analyses in blood were performed over a period of 3 weeks. The chloroquine concentration remained above the therapeutic range (up to 0.5 mg/L) for 2 weeks and dropped to 0.3 mg/L after 3 weeks. Furthermore, monodesethylchloroquine (MDCQ) and bisdesethylchloroquine (BDCQ) were determined to be the most abundant metabolites in plasma. Within 3 weeks, the area ratios of MDCQ and chloroquine increased 4-fold (from 0.090 to 0.350), and those of BDCQ and chloroquine increased 100-fold (from 0.002 to 0.218). This information may help to estimate the chloroquine excretion progress in the future.
Managing Relational Contracts
Authors: Troya-Martinez Marta , Wren-Lewis Liam 
Published: September 2022

Abstract
Relational contracts are typically modeled as being between a principal and an agent, such as a firm owner and a supplier. Yet, in a variety of organizations, relationships are overseen by an intermediary such as a manager. Such arrangements open the door for collusion between the manager and the agent. This paper develops a theory of such managed relational contracts. We show that managed relational contracts differ from principal–agent ones in important ways. First, kickbacks from the agent can help solve the manager’s commitment problem. When commitment is difficult, this can result in higher agent effort than the principal could incentivize directly. Second, making relationships more valuable enables more collusion and hence can reduce effort. We also analyze the principal’s delegation problem and show that she may or may not benefit from entrusting the relationship to a manager.
Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation
Authors: Thornton Christina S , Acosta Nicole , Surette Michael G , Parkins Michael D 
Published: September 2022

Abstract
Chronic lower respiratory tract infections are a leading contributor to morbidity and mortality in persons with cystic fibrosis (pwCF). Traditional respiratory tract surveillance culturing has focused on a limited range of classic pathogens; however, comprehensive culture and culture-independent molecular approaches have demonstrated complex communities highly unique to each individual. Microbial community structure evolves through the lifetime of pwCF and is associated with baseline disease state and rates of disease progression including occurrence of pulmonary exacerbations. While molecular analysis of the airway microbiome has provided insight into these dynamics, challenges remain including discerning not only “who is there” but “what they are doing” in relation to disease progression. Moreover, the microbiome can be leveraged as a multi-modal biomarker for both disease activity and prognostication. In this article, we review our evolving understanding of the role these communities play in pwCF and identify challenges in translating microbiome data to clinical practice.
The Elusive Role of Airway Infection in Cystic Fibrosis Exacerbation
Authors: Caverly Lindsay J , VanDevanter Donald R 
Published: September 2022

Abstract
Cystic fibrosis (CF) pulmonary exacerbations (PEx) are clinical events that commonly result in increased treatment burden, decreased quality of life, and accelerated lung disease progression. CF PEx have historically been approached as though dealing with acute infections, and antibiotic treatments have been associated with improved outcomes. In this review, we discuss data supporting a causal role of CF airway infection in PEx as well studies that highlight our knowledge gaps in regard to PEx definitions, pathophysiology, and optimal treatment approaches. In the era of highly effective cystic fibrosis transmembrane conductance regulator modulator therapy, and the continually increasing health and longevity of persons with CF, a better understanding of PEx and further optimization of PEx antibiotic treatment approaches are needed.
A typed lambda-calculus with first-class configurations
Authors: Abe Tatsuya , Kimura Daisuke 
Published: September 2022

Abstract
Filinski and Griffin have independently succeeded in extending the formulae-as-types notion to deal with continuations. Whereas Griffin adopted control operators primitively, Filinski adopted the duality of functions to construct a symmetric lambda-calculus in which continuations are first-class objects. In this paper, we construct a typed lambda-calculus with first-class configurations consisting of expressions and continuations of the same types. Our calculus corresponds to a natural deduction based on Rumfitt’s bilateralism. Function types are represented as the implication and but-not connectives in intuitionistic and paraconsistent logics, respectively. Our calculus is not only logically consistent, but also computationally consistent. Our calculus with call-by-value and call-by-name strategies correspond to Wadler’s call-by-value and call-by-name dual calculi, respectively. Furthermore, we propose a notion of relaxed configurations, which loosely take expressions and continuations of different types. We confirm that the relaxedness defines control operators for delimited continuations.
The recurrent nova V3890 Sgr: a near-infrared and optical study of the red giant component and its environment
Authors: Kaminsky B , Evans A , Pavlenko Ya V , Woodward C E , Banerjee D P K , Gehrz R D , Walter F , Starrfield S , Ilyin I , Strassmeier K G , Wagner R M 
Published: September 2022

ABSTRACT
We present an analysis of the red giant component of the recurrent nova V3890 Sgr, using data obtained before and after its 2019 eruption. Its effective temperature is Teff = 3050 ± 200 K for log g = 0.7, although there are modest changes in Teff. There is an overabundance of both carbon (0.20 ± 0.05 dex) and sodium (1.0 ± 0.3 dex) relative to their solar values, possibly the result of ejecta from the 1990 nova eruption being entrained into the red giant photosphere. We find 12C/13C =25 ± 2, a value similar to that found in red giants in other recurrent novae. The interpretation of the quiescent spectrum in the 5–38$\, \mu$m region requires the presence of photospheric SiO absorption and cool (∼400 K) dust in the red giant environment. The spectrum in the region of the Na i D lines is complex, and includes at least six interstellar components, together with likely evidence for interaction between ejecta from the 2019 eruption and material accumulated in the plane of the binary. Three recurrent novae with giant secondaries have been shown to have environments with different dust content, but photospheres with similar 12C/13C ratios. The SiO fundamental bands most likely have a photospheric origin in the all three stars.
Infrared spectroscopy of the 2019 eruption of the recurrent nova V3890 Sgr: Separation into equatorial and polar winds revealed
Authors: Evans A , Geballe T R , Woodward C E , Banerjee D P K , Gehrz R D , Starrfield S , Shahbandeh M 
Published: September 2022

ABSTRACT
We present infrared spectroscopy of the 2019 eruption of the recurrent nova V3890 Sgr, obtained over the period of 5.1–46.3 d after the eruption. The spectrum of the red giant became more prominent as the flux declined, and by day 46.3 dominated the spectrum. Hydrogen and helium emission lines consisted of a narrow component superposed on a broad pedestal. The full width at half-maximum of the narrow components declined with time t as the eruption progressed, as t−0.74, whereas those of the broad components remained essentially constant. Conversely, the line fluxes of the narrow components of Pa β remained roughly constant, while those of the broad components declined by a factor ∼30 over a period of ≲ 25 d. The behaviour of the broad components is consistent with them arising in unencumbered fast-flowing ejecta perpendicular to the binary plane, in material that was ejected in a short ∼3.3-d burst. The narrow components arise in material that encounters the accumulated circumstellar material. The outburst spectra were rich in coronal lines. There were two coronal line phases, one that originated in gas ionized by supersoft X-ray source, the other in shocked gas. From the relative fluxes of silicon and sulphur coronal lines on day 23.4 – when the emitting gas was shocked – we deduce that the temperature of the coronal gas was 9.3 × 105 K, and that the abundances are approximately solar.
Sub-parsec resolution cosmological simulations of star-forming clumps at high redshift with feedback of individual stars
Authors: Calura F , Lupi A , Rosdahl J , Vanzella E , Meneghetti M , Rosati P , Vesperini E , Lacchin E , Pascale R , Gilli R 
Published: September 2022

ABSTRACT
We introduce a new set of zoom-in cosmological simulations with sub-pc resolution, intended to model extremely faint, highly magnified star-forming stellar clumps, detected at z = 6.14 thanks to gravitational lensing. The simulations include feedback from individual massive stars (in both the pre-supernova and supernova phases), generated via stochastic, direct sampling of the stellar initial mass function. We adopt a modified ‘delayed cooling’ feedback scheme, specifically created to prevent artificial radiative loss of the energy injected by individual stars in very dense gas (n ∼ 103–105 cm−3). The sites where star formation ignites are characterized by maximum densities of the order of 105 cm−3 and gravitational pressures Pgrav/k &gt;107 K cm−3, corresponding to the values of the local, turbulent regions where the densest stellar aggregates form. The total stellar mass at z = 6.14 is 3.4$\times 10^7~\rm M_{\odot }$, in satisfactory agreement with the observed stellar mass of the observed systems. The most massive clumps have masses of $\sim 10^6~\rm M_{\odot }$ and half-mass sizes of ∼100 pc. These sizes are larger than the observed ones, including also other samples of lensed high-redshift clumps, and imply an average density one orders of magnitude lower than the observed one. In the size–mass plane, our clumps populate a sequence that is intermediate between the ones of observed high-redshift clumps and local dSph galaxies.
A non-linear solution to the S8 tension?
Authors: Amon Alexandra , Efstathiou George 
Published: September 2022

ABSTRACT
Weak galaxy lensing surveys have consistently reported a lower amplitude for the matter fluctuation spectrum, as measured by the S8 parameter, than expected in the ΛCDM cosmology favoured by Planck. However, the expansion history follows the predictions of the Planck ΛCDM cosmology to high accuracy, as do measurements of lensing of the cosmic microwave background anisotropies. Redshift space distortion measurements also appear to be consistent with Planck ΛCDM. In this paper, we argue that these observations can be reconciled with the Planck ΛCDM cosmology if the matter power spectrum is suppressed more strongly on non-linear scales than assumed in analyses of weak galaxy lensing. We demonstrate this point by fitting a one-parameter model, characterizing a suppression of the non-linear power spectrum, to the KiDS-1000 weak lensing measurements. Such a suppression could be attributed to new properties of the dark matter that affect non-linear scales, or to a response of the matter fluctuations to baryonic feedback processes that are stronger than expected from recent cosmological simulations. Our proposed explanation can be tested using measurements of the amplitude of the matter fluctuation spectrum on linear scales, in particular via high precision redshift space distortion measurements from forthcoming galaxy and quasar redshift surveys.