bluuebunny/crossref_metadata_2025_split huggingface dataset:
Roboter-assistierte Hemihepatektomie links mittels Glissonean pedicle approach bei Caroli Syndrom
Authors: Birgin Emrullah , Reissfelder Christoph , Rahbari Nuh N. 
Published: September 2022

Zusammenfassung
Zielsetzung Das Caroli-Syndrom ist eine seltene Gallenwegserkrankung, die durch eine nicht obstruktive Dilatation der intrahepatischen Gallenwege, Leberfibrose und ein erhöhtes
Risiko für ein cholangiozelluläres Karzinom charakterisiert ist. Eine Leberresektion ist beim lokalen Befund die Therapie der Wahl und wird in der Literatur zunehmend minimalinvasiv
durchgeführt. Allerdings wurde in der Literatur bisher eine roboterassistierte Leberresektion beim Caroli-Syndrom nicht beschrieben. Indikation Eine 72-jährige asiatische Patientin
wurde mit einer multifokalen zystischen Dilatation der Lebersegmente II, III und IV unserer Klinik vorgestellt. Bis auf eine konventionelle Appendektomie waren keine weiteren Voroperationen
und Vorerkrankungen, insbesondere keine kongenitalen Zysten, bekannt. Die Leberfunktionsparameter waren unauffällig und die Echinokokkus-Serologie fiel negativ aus. Die MRT-Schnittbildgebung
zeigte eine reguläre Gallenwegsanatomie der rechten Leber. Eine roboterassistierte Hemihepatektomie links mit dem Da Vinci Xi-System wurde geplant. Methode Die roboterassistierte
Hemihepatektomie links wurde in einer Französischlagerung durchgeführt. Zunächst erfolgte eine Adhäsiolyse und Cholezystektomie. Eine aberrante Leberarterie aus der A. gastrica sinistra
wurde mithilfe von Clips abgesetzt. Nach Senkung der hilären Platte wurde der linke Pedikel en bloc mittels Glissonean Pedicle Approach umfahren und mit einer Bulldog-Klemme ausgeklemmt.
Eine ischämische Demarkationslinie zur rechten Leber zeichnete sich auf der Leberoberfläche ab. Die Parenchymdissektion wurde mittels bipolarer Pinzette durchgeführt. Ein Pringle-Manöver
wurde nicht angewendet. Der linke Pedikel und die linke Lebervene wurden mit einem robotischen Linearstapler abgesetzt und die mittlere Lebervene erhalten. Die regelrechte Perfusion der
Restleber inkl. Segment I wurde mittels intravenöser Indocyaningrünapplikation (ICG) in einer Dosierung von 0,2 mg/kg Körpergewicht bestätigt. Das Resektat wurde in einen Bergebeutel
verbracht und über einen Pfannenstiel-Schnitt geborgen. Die OP-Zeit betrug 239 min mit einem Gesamtblutverlust von 100 ml. Die Patientin wurde am 5. postoperativen Tag entlassen. Der
histologische Befund bestätigte ein Caroli-Syndrom. In der 6-Monats-Verlaufskontrolle hatte die Patientin eine regelrechte Leberfunktion ohne Zeichen einer rezidivierenden Erkrankung.
Schlussfolgerung Eine Hemihepatektomie links ist in der Glissonean-Pedicle-Approach-Technik sicher roboterassistiert durchführbar und ein geeignetes Verfahren für die Therapie des
Caroli-Syndroms.
Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (–)-Melearoride A and Antibiotic (–)-PF1163B
Authors: Pabbaraja Srihari , Yasam Bharath Kumar 
Published: September 2022

AbstractA flexible stereoselective and convergent cum divergent approach to the synthesis of two 13-membered macrolides through a common skeleton present in their structure is described featuring two different routes, with good overall yield. The key synthetic reactions utilized include Keck allylation, Evans asymmetric methylation, Grubbs metathesis, and Julia–Kocienski olefination.
Copper Nitrate Mediated Regioselective Difunctionalization of Alkenes with N-Fluorobenzenesulfonimide: A Direct Approach to β-Aminonitrates
Authors: Ding Chang-Hua , Xu Bin , Zhou Kaijing , Yin Li , Guo Ying 
Published: September 2022

AbstractAn efficient copper nitrate mediated difunctionalization of alkenes with N-fluorobenzenesulfonimide (NFSI) has been developed for the direct synthesis of β-aminonitrates in moderate to excellent yields with high regioselectivity. This reaction proceeds through a radical process, where copper nitrate is used as the nitrate source and NFSI as the nitrogen source. The given protocol provides a direct access to functionalized nitrates with operational simplicity, good functional group tolerance, and a wide substrate scope. The reaction can be performed on a gram scale and the synthetic utility of the product is demonstrated.
Starting gastrointestinal endoscopy in a lower middle-income country in Africa: Training, creating an endoscopy facility and developing telemedicine
Authors: Campos Sara T. , Barreto Lagchar , Fernandes Vítor , Meira Tânia , Portela Francisco , Carreira Cátia , Nunes Ana Margarida , d’Apresentação Pascoal , Barreto Laurinda , Lima Wrciley , da Costa Dʼjarda , Zhaky Ahmed , Freitas Paulo 
Published: September 2022

Abstract
Background and study aims The prevalence of digestive diseases seems to be high in African countries. Nonetheless, the human and material resources are scarce. The aim of the Portuguese volunteering project described in this report was to develop the specialty of digestive endoscopy in Sao Tome and Principe, a lower-middle-income country in Africa.
Methods Beginning by assessing the local needs and available resources and managing immediate issues related to this field, we aimed to provide the tools necessary to improve gastroenterological and endoscopic care in the country. The first step included training of the local teams, through the development and accomplishment of an adapted curriculum for a 3-year medical gastroenterological fellowship and a short-term nursing fellowship, both in Portugal, and the organization of regular gastroenterological and endoscopic theoretical and practical sessions in Sao Tome and Principe. Second, the endoscopy facilities of the unit were significantly optimized. Third, a web platform was designed to provide telemedicine incorporating real-time endoscopic imaging available remotely.
Results Through these sequential steps achieved in collaboration with Portuguese and local teams, this 5-year project provided the basis for gastroenterology care in this country.
Conclusions At the present time, Sao Tome and Principe has an autonomous, efficient and skilled team and unit to provide care for patients with gastrointestinal diseases who need endoscopic procedures.
A new device for endoscopic band ligation for colorectal diverticular bleeding
Authors: Kikuchi Daisuke , Hayasaka Junnosuke , Uruga Hironori , Fujii Takeshi , Ochiai Yorinari , Hoteya Shu 
Published: September 2022

Abstract
Background and study aims Endoscopic band ligation (EBL) has been reported to be effective for colorectal diverticular bleeding. However, current EBL devices have some limitations, and we have developed a novel EBL device.
Methods This novel EBL device has a tapered hood attached to the tip of the endoscope and an outer cylinder that loads two EBL bands. Twelve EBL procedures were performed in a live porcine model alternately using a conventional EBL device (Group C) and the novel EBL device (Group N).
Results EBL was successful in all cases in both groups. There were no cases of perforation in the 10 days after EBL. After ligation, the mean major axis of the ridge was significantly larger in Group N than Group C (9.7 ± 1.4 mm vs 7.2 ± 1.4 mm, P = 0.011). Pathological examination revealed disruption of the muscularis propria at four of the six ligation sites in Group C and at five of the six ligation sites in Group N.
Conclusions Using this novel EBL device, it was possible to perform multiple ligation procedures in succession with a good field of view. No perforation was observed, but disruption of the muscularis propria was observed at approximately three-quarters of the ligation sites pathologically.
One-Pot, Base- and Metal-Free Practical Synthesis of Novel Cycloalkene-Fused [1,4]Thiazepines through the Sequential Ugi/SNCsp2 Reactions
Authors: Al-Harrasi Ahmed , Takallou Ahmad , Al-Shidhani Sulaiman , Anwar Muhammad U. 
Published: September 2022

AbstractA one-pot and sequential Ugi/SNCsp2 four-component reaction was introduced for the synthesis of cycloalkene-fused [1,4]thiazepine derivatives. A variety of cyclic β-bromovinyl aldehyde with different sizes, amines, and isocyanides were reacted with thioglycolic acid. This approach can provide a practical and rapid access to the fused bioactive cycloalkene structures containing thiazepine, and peptide unit, which proved the achievement of a significant structural diversity. Further use of this method has been successfully applied in synthesizing a variety of quinoline-fused [1,4]thiazepines with satisfactory results. The practical nature of this approach was demonstrated by a gram-scale synthesis of a selected product.
Total Synthesis of Geranyl-Resorcinols Isolated from Mushrooms of Genus Hericium
Authors: Kobayashi Shoji 
Published: September 2022

AbstractThis Short Review covers the total synthesis of tetraketide-based meroterpenoids, i.e. geranyl-resorcinols, isolated from the mushrooms of genus Hericium. Some of these compounds are believed to be involved in the unique health-promoting effects of Hericium erinaceus. Herein, more than seventy natural products identified so far have been classified into seven-types based on both assumed biosynthetic pathways and chemical structures, and the successful total syntheses are summarized according to the structural type.1	Introduction2	Pioneering Synthetic Study3	Total Synthesis of Geranyl-Resorcinol with a Geranyl Side Chain (Types 1, 3, and 6)4	Total Synthesis of Geranyl-Resorcinol with an Oxidized Geranyl-Derived Side Chain (Types 2, 4, and 7)5	Conclusion
The Association of Methylenetetrahydrofolate Reductase (MTHFR) A1298C
Gene Polymorphism with Susceptibility to Diabetic Nephropathy: A
Meta-Analysis
Authors: Huo Yanhong , Zhang Wenbo , Zhang Xin , Su Li , Li Hao , Wang Fa , Zhang Yan 
Published: September 2022

AbstractThis meta-analysis was conducted to investigate the association between MTHFR
A1298C polymorphism and susceptibility to diabetic nephropathy. PubMed, Embase,
Web of Science, Cochrane Library, China national knowledge infrastructure (CNKI)
and China Wanfang database were searched for studies on the association between
MTHFR A1298C single nucleotide polymorphism and susceptibility to diabetic
nephropathy until May 2022. Data were analyzed by Stata 15.0 software. Odds
ratio (OR) was used as the effect size. A total of 7 articles were identified,
including 1287 cases in the diabetic nephropathy group and 1431 cases in the
control group. The pooled OR of allele C at MTHFR A1298C was 1.28 (95%
CI: 1.02–1.59, p=0.03) compared with allele A. The pooled OR
values of dominant, and heterozygous genetic models were 1.45 (95% CI:
1.13–1.86), and 1.42 (95% CI: 1.19–1.70), respectively,
and the differences were all statistically significant. There was no statistical
significance in the recessive (OR=1.06, 95% CI:
0.62–1.82), and homozygous gene inheritance models (OR=1.29,
95% CI: 0.72–2.31). In conclusion, MTHFR A1298C polymorphism is
associated with susceptibility to diabetic nephropathy. Allele C, genotype
CC+AC, and AC at MTHFR A1298C locus can increase the risk of diabetic
nephropathy.
Acute Hepatitis C Virus Infection Treated with Daclatasvir/Sofosbuvir in a 9-Year-Old Boy
Authors: Rahmani Parisa , Farahmand Fatemeh , Heidari Ghobad 
Published: September 2022

AbstractThe present study includes a case report of a 9-year-old boy who came to our center with jaundice, elevated liver enzymes, and palpable liver. He was treated with ursodeoxycholic acid, but no improvement in symptoms was seen. Reverse transcription polymerase chain reaction and liver biopsy were positive for hepatitis C virus. He was treated with daclatasvir/sofosbuvir for 3 months. Daclatasvir/sofosbuvir might be effective against the treatment of hepatitis in children, with no report of remission and minimal side effects.
The Role of Codon Usage, tRNA Availability, and Cell Proliferation in EBV Latency and (Re)Activation
Authors: Kanduc Darja 
Published: September 2022

AbstractEpstein–Barr nuclear antigen 1 (EBNA1) protein synthesis is inhibited during Epstein–Barr virus (EBV) latency and is resumed in EBV (re)activation. In analyzing the molecular mechanisms underpinning the translation of EBNA1 in the human host, this article deals with two orders of data. First, it shows that the heavily biased codon usage of the EBNA1 open reading frame cannot be translated due to its noncompliance with the human codon usage pattern and the corresponding tRNA pool. The EBNA1 codon bias resides in the sequence composed exclusively of glycine and alanine, i.e., the Gly-Ala repeat (GAR). Removal of the nucleotide sequence coding for GAR results in an EBNA1 codon usage pattern with a lower codon bias, thus conferring translatability to EBNA1. Second, the data bring cell proliferation to the fore as a conditio sine qua non for qualitatively and quantitatively modifying the host's tRNA pool as required by the translational needs of EBNA1, thus enabling viral reactivation. Taken together, the present work provides a biochemical mechanism for the pathogen's shift from latency to (re)activation and confirms the role of human codon usage as a first-line tool of innate immunity in inhibiting pathogens' expression. Immunologically, this study cautions against using codon optimization and proliferation-inducing substances such as glucocorticoids and adjuvants, which can (re)activate the otherwise quiescent, asymptomatic, and innocuous EBV infection. Lastly, the data pose the question whether the causal pathogenic role attributed to EBV should instead be ascribed to the carcinogenesis-associated cellular proliferation.
The Effect of Aminophylline on Urine Output and Fluid Balance after a Single Dose in Children Admitted to the Pediatric Cardiac Intensive Care Unit
Authors: Loomba Rohit S. , Uppuluri Sruti , Chandra Priya , Yousef Faeeq , Dorsey Vincent , Farias Juan S. , Flores Saul , Villarreal Enrique G. 
Published: September 2022

AbstractThe purpose of this retrospective study was to investigate the effects of a single dose of aminophylline on urine output and fluid balance in children admitted to the cardiac intensive care unit. A retrospective study was performed to compare variables of interest before and 24 hours after aminophylline administration in children under the age of 18 years who were admitted to the cardiac intensive care unit at our institution from January 2011 onwards. Variables of interest included age, weight, aminophylline dose, concurrently administered diuretics, specific hemodynamic parameters, and blood urea nitrogen and creatinine levels. Variables such as urine output and fluid balance were measured through a binary endpoint. Data were compared in a paired fashion and continuous variables were compared through paired t-tests. Analyses were conducted using SPSS Version 23.0. A total of 14 patients were included in the study. There was no significant change in hemodynamic parameters or creatinine levels before and after intravenous aminophylline administration of 5 mg/kg. There was a significant difference in urine output, fluid balance, and blood urea nitrogen levels from the baseline value. Concurrent usage of diuretics did not show significant association with a difference in urine output or fluid balance from baseline. No significant adverse reactions were noted 24 hours after administration of aminophylline. Use of aminophylline dosed at 5 mg/kg is safe and leads to improvement in urine output and fluid balance without negatively impacting systemic oxygen delivery or renal filtration function.
Risk Factors for Left Ventricular Thrombus Formation in Patients with Dilated Cardiomyopathy
Authors: Wu Hao-Sheng , Dong Jian-Zeng , Du Xin , Hu Rong , Jia Chang-Qi , Li Xu , Wu Jia-Hui , Ruan Yan-Fei , Yu Rong-Hui , Long De-Yong , Ning Man , Sang Cai-Hua , Jiang Chen-Xi , Bai Rong , Wen Song-Nan , Liu Nian , Li Song-Nan , Wang Wei , Guo Xue-Yuan , Zhao Xin , Zuo Song , Cui Yi-Kai , Tang Ri-Bo , Ma Chang-Sheng 
Published: September 2022

Abstract
Background Left ventricular thrombus (LVT) is a common complication of dilated cardiomyopathy (DCM), causing morbidity and mortality.
Methods This study retrospectively analyzed patients with DCM from January 2002 to August 2020 in Beijing Anzhen Hospital. Clinical characteristics were compared between the LVT group and the age and sex 1:4 matched with the LVT absent group. The receiver operator characteristic (ROC) curve was plotted to evaluate the diagnostic value of D-dimer predicting LVT occurrence in DCM.
Results A total of 3,134 patients were screened, and LVT was detected in 72 (2.3%) patients on echocardiography. The patients with LVT had higher D-dimer, fibrinogen, and lower systolic blood pressure than those without LVT. The ejection fraction (EF) was lower and left ventricular end-systolic diameter was larger in the LVT group. Severe mitral regurgitation (MR) was more common in the LVT absent groups. The prevalence of atrial fibrillation was lower in the LVT group. The ROC curve analysis yielded an optimal cut-off value of 444 ng/mL DDU (D-dimer units) for D-dimer to predict the presence of LVT. Multivariable binary logistic regression analysis revealed that EF (OR = 0.90, 95% CI = 0.86–0.95), severe MR (OR = 0.19, 95% CI = 0.08–0.48), and D-dimer level (OR = 15.4, 95% CI = 7.58–31.4) were independently associated with LVT formation.
Conclusion This study suggested that elevated D-dimer levels (>444 ng/mL DDU) and reduced EF were independently associated with increased risk of LVT formation. Severe MR could decrease the incidence of LVT.
Myoclonus-Dystonia in an Individual with a Mutation in the GRIN2A Gene
Authors: Al Qahtani Xena , Multhaupt-Buell Trisha , Sharma Nutan , Dy-Hollins Marisela E. 
Published: September 2022

AbstractMutations in the GRIN2A gene are associated with epilepsy-aphasia spectrum disorders and developmental and epileptic encephalopathies. Associations have been linked with disorders, including autism spectrum disorder and Parkinson's disease. Recently, GRIN2A variants have been reported as a cause of movement disorders in individuals without epilepsy, suggesting that movement disorders should be highlighted as a genetic phenotype associated with pathogenic variants in GRIN2A. We present a case of a male with myoclonus dystonia and without epilepsy found on whole-exome sequencing to have a c.1880G > A; p.S627N variant in the GRIN2A gene. Our case contributes to the expanding phenotypic spectrum of GRIN2A-related disorders and highlights another genetic cause of the myoclonus-dystonia phenotype. GRIN2A should be considered a part of the differential diagnosis of myoclonus-dystonia in individuals with developmental delay without epilepsy.
Temporal Trend of COVID-19 Clinical Severity and the Ethnic/Racial Disparity: A Report from the Maryland Study Group
Authors: Cojocaru Liviu , Pahlavan Autusa , Tadbiri Hooman , Seung Hyunuk , Reddy Ramya , Mangione Mary E. , Uribe Katelyn , Ufua Michelle , Stockett Arica M. , Jones-Beatty Kimberly , Burd Irina , Turan Ozhan M. , Turan Sifa 
Published: September 2022

Objectives This study aimed to evaluate the temporal trend of novel coronavirus disease 2019 (COVID-19) symptoms and severity of clinical outcomes among pregnant women over a calendar year in the State of Maryland and compare clinical outcomes between different ethnic and racial groups.
Study Design We conducted a retrospective, multicenter observational study of the temporal trend of COVID-19 clinical presentation during pregnancy in the State of Maryland. We reviewed consecutive charts of adult pregnant females, aged 18 to 55 years, with laboratory-confirmed severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection between March 1, 2020, and February 28, 2021, and managed within the University of Maryland Medical System and Johns Hopkins Medicine. We excluded cases with insufficient data for assessing the COVID-19 diagnosis, pregnancy status, or clinical outcomes. We evaluated the evolution of COVID-19 symptoms at the time of presentation. Also, we compared COVID-19 infection rate, hospitalization rate, oxygen use, and intensive care unit (ICU) admission rates between different ethnic and racial groups.
Results We included 595 pregnant women with laboratory-confirmed COVID-19 over the study period. The prevalence of respiratory and systemic symptoms decreased over time with incidence rate ratios (IRRs) of 0.91 per month (95% confidence interval [CI]: 0.88–0.95) and 0.87 per month (95% CI: 0.83–0.95), respectively. The prevalence of hospitalization, O2 requirement, and ICU admission decreased over time with IRRs of 0.86 per month (95% CI: 0.82–0.91), 0.91 per month (95% CI: 0.84–0.98), and 0.70 per month (95% CI: 0.57–0.85), respectively. The Hispanic and Black populations had a higher COVID-19 infection rate and hospitalization rate than the non-Hispanic White population (p = 0.004, < 0.001, and < 0.001, respectively).
Conclusion Understanding the concepts of viral evolution could potentially help the fight against pandemics like COVID-19. Moreover, this might improve the knowledge of how pandemics affect disadvantaged populations and help close the gap in health care inequities.
Key Points
Resonant cold scattering of highly vibrationally excited D2 with Ne
Authors: Perreault William E. , Zhou Haowen , Mukherjee Nandini , Zare Richard N. 
Published: September 2022

To accurately map weak D2–Ne long-range interactions, we have studied rotationally inelastic cold scattering of D2 prepared in the vibrationally excited (v = 4) and rotationally aligned (j = 2, m) quantum state within the moving frame of a supersonically expanded mixed molecular beam. In contrast to earlier high energy D2–Ne collision experiments, the (j = 2 → j′ = 0) cold scattering produced highly symmetric angular distributions that strongly suggest a resonant quasi-bound collision complex that lives long enough to make a few rotations. Our partial wave analysis indicates that the scattering dynamics is dominated by a single resonant l = 2 orbital, even in the presence of a broad temperature (0–5 K) distribution that allows incoming orbitals up to l = 5. The dominance of a single orbital suggests that the resonant complex stabilizes through the coupling of the internal (j = 2) and orbital (l = 2) angular momentum to produce a total angular momentum of J = 0 for the D2–Ne complex.
Speakers’ subjective evaluation of adversity
Authors: Su Danjie 
Published: September 2022

AbstractAdversative passives like Mandarin Chinesebei-passives are known to convey adversity, but what “adversity” means specifically for speakers ofbei-in conversational discourse remains unknown. Whereas previous studies examine adversity within thebei-clause, this study uses the lens concept to investigate speakers’ subjective evaluations of the event attested by the larger context beyond thebei-clause. Using a subjectivity coding scheme and the discourse adjacent alternation method, I analyzed 4,203 values of event valence of 1,401bei-utterances and 65 alternations in spontaneous talk show conversations. Results show that: (1) The same event that a speaker evaluates as “adverse” usingbei- is sometimes evaluated as “non-adverse” using non-beistructures. (2) The samebei+verb phrase that previous studies may deem “adverse” can be evaluated as “adverse” or “positive” by actual speakers. (3) 84.5% (1,184/1,401) of the time,bei-passive in conversation expresses speakers’ evaluation that a causative event is adverse for the affectee, regardless of what reality is. (4) Adversity means undesirable, disadvantageous, morally or socially wrong, empathy-deserving, and/or sympathy-deserving for speakers ofbei-. The findings indicate that the adversity thatbei-conveys is not an objective description of reality but a subjective evaluation independent of reality–the Adversity lens. This study sheds light on subjectivity and specific manifestations of adversity in conversational discourse.