bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strong Red Up‐Conversion Emission in Thin Film Devices Based on Rare‐Earth Oxides Obtained from Templating 2D Coordination Networks
Authors: Godoy Agustín A. , Gomez Germán E. , Miranda Carlos D. , Illescas Marcos , Barja Beatriz C. , Vega Daniel , Bernini María C. , Narda Griselda E. 
Published: February 2022

AbstractCoordination networks (CNs) with tailorable multi‐metallic composition were designed and then used as sacrificial materials to obtain promising materials with Up‐conversion (UC) properties. The metal‐organic precursors led to solid solutions of Rare‐Earth Oxides (REO)Y2O3:Yb3+/Er3+or Y2O3:Yb3+/Er3+/Gd3through a calcination process. In order to obtain luminescent UC platforms, spin‐coating technique was implemented to deposit these materials onto glass supports. The synthesized solids and the resulting films were characterized by Scanning Electron Microscopy – Energy Dispersive Spectroscopy (SEM‐EDS), infrared spectroscopy, powder (PXRD), and grazing incidence (GIXRD) X‐ray diffraction techniques. Moreover, the photophysical properties of bulk and deposited Y2O3:Ln3+doped oxides were evaluated after being irradiated with NIR wavelength (980 nm) laser to excite the Yb3+sensitizer ion. Besides, decay emission profiles from each sample were also obtained and lifetime (τobs) values were calculated. These results open up the implementation of REO thin films obtained through CN calcination for promising applications such as solar cells and sensor devices.
Palladium‐Catalyzed Suzuki Coupling and NIS‐Mediated Dehydrogenative Cylcoetherification: A Concise Approach to 6,6‐Disubstituted 6H‐benzo[c]chromenes and Total Synthesis of Didehydroconicol
Authors: Shekhar Chander , Satyanarayana Gedu 
Published: February 2022

AbstractBenzo[c]chromones are valuable tricyclic systems of natural and biological significance. Herein, we report a concise approach of 6,6‐disubstituted 6H‐benzo[c]chromenes in a two‐step sequence starting from ortho‐bromo benzylic alcohols and arylboronic acids, using intermolecular palladium‐catalyzed C−C and intramolecular N‐Iodosuccinimide (NIS) mediated key C−O bonds construction. Besides, the current method explored broad substrate scope under robust conditions. Notably, the practicality of the present approach is further extended for the total synthesis of Didehydroconicol.
Divergent Annulation of Spiro[indoline‐pyran] and Fused (Epoxyetheno)indeno‐Furan from 1,2‐Diketone and 1‐Cyanoketone
Authors: Yadav Maruti B. , Vagh Sandip S. , Jeong Yeon Tae 
Published: February 2022

AbstractA simple and efficient method for the construction of spiro[indoline‐pyran] and fused (epoxyetheno)indeno[1,2‐b]furan compounds from 1‐cyanoketones and 1,2‐diketone has been developed. The synthesis proceeded via the Knoevenagel and Michael adduct through intramolecular/Paal‐Knorr cyclization under similar reaction condition. The less commonly used 1‐cyanoketones and active carbonyl compounds served as the indole containing pyran and bicyclic furan source for the preparation of a new series of heterocyclic compounds. This heterocyclic structure allows one and more than one tetra‐substituted carbon center and sequential hexa‐ and penta‐cyclic core under very mild conditions and shows excellent chemo and regioselectivity. In addition, the synthesis of spiro[indoline‐pyran] and (epoxyetheno)indeno[1,2‐b]furan was demonstrated in a gram scale.
Influence of carbon binder domain on the performance of lithium‐ion batteries: Impact of size and fractal dimension
Authors: Chauhan Anshuman , Asylbekov Ermek , Kespe Susanne , Nirschl Hermann 
Published: February 2022

AbstractA lithium‐ion battery (LIB) cathode comprises three major components: active material, electrical conductivity additive, and binder. The combination of binder and electrical conductivity additive leads to the formation of composite clusters known as the carbon binder domain (CBD) clusters. Preparation of a LIB cathode strongly influences the dispersion of the above‐mentioned constituents leading to the formation of distinct pore and electrical conduction networks. The resulting structure thus governs the performance of LIBs. The presence of CBD is essential for the structural integrity and sufficient electrical conductivity of the LIB cathode. However, CBD abundance in LIB cathodes leads to unfavorable gravimetrical and volumetrical consequences owing to its electrochemical inertness. Increasing CBD content adds to the weight of the LIBs, thus negatively impacting the energy density. Furthermore, increased electrical conductivity is won at a cost of ionic conductivity as CBD clusters breach the pore networks in the cathode microstructure. The following study establishes a link between the various possibilities of CBD cluster size and fractal dimension that may eventualize during the mixing process of slurry preparation to the resulting microstructural properties and hence to the performance of LIBs by means of idealized cathode geometries. Since the performance determining processes occur at the microstructural scale, which are often very tedious to study via experimental research, the study makes use of spatially resolving microstructural, numerical, simulations. The results demonstrate that the CBD cluster size has a strong influence on the cathode microstructure. The CBD cluster fractal dimension on the other hand displayed a minor influence on the structural properties of the cathode, and the size of the cluster primary particles was shown to be the dominant factor. Finally, performance evaluation simulations confirmed the trends seen in structural properties with changing cluster size and fractal dimension.
Recent advances in ion‐sensitive field‐effect transistors for biosensing applications
Authors: Ma Xiaohao , Peng Ruiheng , Mao Wei , Lin Yuanjing , Yu Hao 
Published: February 2022

AbstractOver the past decades, considerable development and improvement can be observed in the area of the ion‐sensitive field‐effect transistor (ISFET) for biosensing applications. The mature semiconductor industry provides a solid foundation for the commercialization of the ISFET‐based sensors and extensive research has been conducted to improve the performance of ISFET, with a special research focus on the materials, device structures, and readout topologies. In this review, the basic theories and mechanisms of ISFET are first introduced. Research on ISFET gate materials is reviewed, followed by a summary of typical gate structures and signal readout methods for the ISFET sensing system. After that, a variety of biosensing applications including ions, deoxyribonucleic acid, proteins, and microbes are presented. Finally, the prospects and challenges of the ISFET‐based biosensors are discussed.
Nano‐scale BN interface for ultra‐stable and wide temperature range tolerable Zn anode
Authors: Jia Hao , Qiu Minghui , Tang Chunxia , Liu Hongqi , Fu Shaohai , Zhang Xiangwu 
Published: February 2022

AbstractAqueous Zn‐based energy storage device (ZESD) is a promising candidate for large‐scale energy storage applications due to its significant merits like low cost, inherent safety, and environmental benignity. However, one shortcoming of ZESDs is the performance deficiency of pristine Zn anode caused by detrimental dendrite formation and side reactions. In this work, a novel boron nitride nano‐scale interface was established for ultra‐stable and wide temperature range tolerable anode (BN@Zn) by a scalable magnetron sputtering technique. The as‐introduced BN layers afford enhanced Zn deposition kinetics for a wide temperature application range from −20 to 60°C and effectively mitigated dendritic growth, which were ascribed to the strong interlayer bonds and uniform active sites as demonstrated by both experimental and density functional theory research results. Thus, the ultra‐thin BN interface could significantly improve the reaction kinetics and electrochemical stability of Zn anode, providing a new perspective towards the advanced ZESDs.image
Large‐scale fabrication of core‐shell triboelectric braided fibers and power textiles for energy harvesting and plantar pressure monitoring
Authors: Li Yingying , Zhang Yihan , Yi Jia , Peng Xiao , Cheng Renwei , Ning Chuan , Sheng Feifan , Wang Sen , Dong Kai , Wang Zhong Lin 
Published: February 2022

AbstractFlexible and wearable energy harvesting devices and multifunctional sensors have been widely reported, but challenges in the large‐scale manufacturing process still exist. This work reports a large‐scale fabrication method of core‐shell triboelectric braided fibers that exhibit stable structure and strong tensile strength, which can be further integrated into power textiles with different fabric structures, such as weaving and knitting, with the purpose of biomechanical energy harvesting or plantar pressure monitoring. The triboelectric braided fibers integrating on the knitting power textiles exhibit good pressure sensitivity and fatigue resistance, which is combined with traditional socks to measure the pressure distribution of the plantar in different positions. The weaving power textiles exhibit high electrical output, which can be used for biomechanical energy harvesting and can easily light up 116 commercial LEDs. This large‐scale preparation approach provides more possibilities for power textiles applications in self‐powered wearable electronics and human–computer interfacing.
Experimental study on the combustion of low‐calorific NG/N2 in a porous burner
Authors: Wang Guanqing , Shi Zhongyu , Xu Guohua , Luo Dan , Xu Jiangrong 
Published: February 2022

AbstractLarge amounts of low‐calorific fuel gas without oxygen (LCFGWO), generated by industry every year, are hardly utilized by the conventional combustion technology. Here, an LCFGWO mixture was simulated by diluting natural gas (NG) with nitrogen (N2), and its combustion under different lower heating values (LHV) was experimentally investigated in a SiC ceramic foam burner via an intermittent operation method. The key operating parameters of the burner (i.e., LHV, superficial velocity, and excess air ratio) were analyzed by focusing on its combustion characteristics (temperature profiles, super‐adiabatic effects, and emissions). The results showed that the initial position of the combustion flame was anchored downstream with decreasing LHV. As the LHV decreased to 3.36 MJ/Nm3, super‐adiabatic combustion began to appear, and the super‐adiabatic ratio slightly increased with decreasing LHV. Further, clean combustion of the NG/N2 mixtures in the burner could be achieved over a wide range of LHV with an optimal excess air ratio ranging from 1.3 to 1.5. Subsequently, the length of the porous medium was discussed in terms of the optimal excess air ratio. Its minimum length required to burn the NG/N2 mixtures was found to decrease exponentially with increasing LHV, and an exponential function was fitted to the experimental data. A mathematic correlation for designing the burner length was obtained by considering the effect of flame propagation velocity. These results are helpful toward the design of porous burners for the clean combustion of low‐calorific NG/N2.
Autoimmune hepatitis in pregnancy: Pearls and pitfalls
Authors: Chung Y. Y. , Heneghan Michael A. 
Published: February 2022

Abstract
Autoimmune hepatitis (AIH) in pregnancy has many unique considerations. Evidence provided from single center studies with patient level data and nationwide population studies provide valuable insight into this complex situation. Because a planned pregnancy is a safer pregnancy, preconception counseling is a crucial opportunity to optimize care and risk stratify women with AIH. Women with chronic liver disease who receive preconception advice and counseling are more likely to achieve stable liver disease at conception and undergo appropriate variceal surveillance. Loss of biochemical response in pregnancy is associated with adverse outcomes in unstable disease. New onset AIH in pregnancy should be managed with classical treatment regimens. The continued use of immunosuppression in pregnancy, with the exception of mycophenolate mofetil, has not shown to adversely affect the rates of stillbirth or congenital malformation. Previously adopted immunosuppression withdrawal paradigms in pregnancy should no longer be considered advantageous, because remission loss postdelivery is likely (12%–86%). Population studies, report improved outcomes with preterm birth rates falling from 20% to 9%–13% in AIH pregnancies over a 20‐year period. Newer data have also demonstrated an increased risk of gestational diabetes and hypertensive complications in AIH pregnancy, which has implications for management and preeclampsia prevention with aspirin use. This review aims to provide the framework to guide and manage pregnancy in AIH outlining pearls and pitfalls to ensure optimal outcomes for mother, baby and to reduce variation in practice.
A hierarchical regulatory network ensures stable albumin transcription under various pathophysiological conditions
Authors: Feng Rilu , Kan Kejia , Sticht Carsten , Li Yujia , Wang Shanshan , Liu Hui , Shao Chen , Munker Stefan , Niess Hanno , Wang Sai , Meyer Christoph , Liebe Roman , Ebert Matthias P. , Dooley Steven , Ding Huiguo , Weng Honglei 
Published: February 2022

Abstract

Background and Aims
It remains unknown how patients with liver failure maintain essential albumin levels. Here, we delineate a hierarchical transcription regulatory network that ensures albumin expression under different disease conditions.

Approach and Results
We examined albumin levels in liver tissues and serum in 157 patients, including 84 with HCC, 38 decompensated cirrhosis, and 35 acute liver failure. Even in patients with liver failure, the average serum albumin concentrations were 30.55 g/L. In healthy subjects and patients with chronic liver diseases, albumin was expressed in hepatocytes. In patients with massive hepatocyte loss, albumin was expressed in liver progenitor cells (LPCs). The albumin gene (ALB) core promoter possesses a TATA box and nucleosome‐free area, which allows constitutive RNA polymerase II binding and transcription initiation. Chromatin immunoprecipitation assays revealed that hepatocyte nuclear factor 4 alpha (HNF4α), CCAAT/enhancer‐binding protein alpha (C/EBPα), and forkhead box A2 (FOXA2) bound to the ALB enhancer. Knockdown of either of these factors reduced albumin expression in hepatocytes. FOXA2 acts as a pioneer factor to support HNF4α and C/EBPα. In hepatocytes lacking HNF4α and C/EBPα expression, FOXA2 synergized with retinoic acid receptor (RAR) to maintain albumin transcription. RAR nuclear translocation was induced by retinoic acids released by activated HSCs. In patients with massive hepatocyte loss, LPCs expressed HNF4α and FOXA2. RNA sequencing and quantitative PCR analyses revealed that lack of HNF4α and C/EBPα in hepatocytes increased hedgehog ligand biosynthesis. Hedgehog up‐regulates FOXA2 expression through glioblastoma family zinc finger 2 binding to the FOXA2 promoter in both hepatocytes and LPCs.

Conclusions
A hierarchical regulatory network formed by master and pioneer transcription factors ensures essential albumin expression in various pathophysiological conditions.
Immunoglobulin M: A Neglected Serum Biomarker in Treatment‐Naive Primary Biliary Cholangitis With Normal Alkaline Phosphatase
Authors: Ding Dawei , Xuan Guoyun , Hu Yinan , Yu Jiahao , Liu Yansheng , Guo Guanya , Ma Shuoyi , Yang Fangfang , Tian Siyuan , Ma Gang , Chen Ling , Zhou Xinmin , Shang Yulong , Han Ying 
Published: February 2022

The diagnosis of primary biliary cholangitis (PBC) in patients with seropositive anti‐mitochondrial antibody (AMA) but normal alkaline phosphatase (ALP) depends on a liver biopsy. We aimed to reveal potential serum biomarkers that could suggest the necessity of a liver biopsy in such patients. Retrospective analysis was performed. Subjects who were treatment naive with seropositive AMA but normal ALP and who underwent at least one liver biopsy between 2008 and 2020 were included in this study. Histologic biopsies were evaluated by two experienced pathologists blinded to the serum tests. A total of 115 patients who were treatment naive were included in this study. Of these, 77 patients (67%) exhibited histologic PBC features and nonspecific histologic features were found in the remaining 38 (33%) patients. Multivariate analysis suggested that baseline serum immunoglobulin M (IgM) >0.773 × upper limit of normal (ULN) (P < 0.001) and age >42 years (P = 0.002) were associated with the diagnosis of PBC through liver biopsies. A significant decrease in the median levels of gamma‐glutamyl transpeptidase (GGT) and IgM was found in 54 patients with PBC who received ursodeoxycholic acid (UDCA). Conclusion: For patients who were treatment naive with seropositive AMA but normal ALP, baseline serum IgM >0.773 × ULN and age >42 years were the factors that strongly suggested a diagnosis of PBC. In these patients receiving UDCA, a dynamic monitoring of GGT and IgM might be helpful in evaluating therapeutic responses.
Team boundary work and team workload demands: Their interactive effect on team vigor and team effectiveness
Authors: Leicht‐Deobald Ulrich , Lam Chak Fu , Bruch Heike , Kunze Florian , Wu Wen 
Published: February 2022

AbstractDrawing from team‐level job demands‐resources theory, we hypothesize that team workload demands moderate the positive link between team boundary work (i.e., boundary spanning and boundary buffering) and team effectiveness (i.e., team innovation and team performance), such that boundary work is more beneficial for team effectiveness when teams face higher team workload demands. Furthermore, we predict that this interaction occurs through increased team vigor, where team vigor is defined as an affective emergent state characterized by positive valences and high activation levels experienced by team members. We largely find support for our model across two field studies: a cross‐sectional survey using three independent data sources (89 automotive research and development teams, including 724 team members, 89 team leaders and 18 managers) and a time‐lagged survey using two independent data sources (139 teams working in a Chinese utility company, including 640 team members and 139 team leaders). Our article contributes to team research by broadening our understanding of when and how team boundary work is associated with greater team effectiveness.
Dietary fats and their sources in association with the risk of bladder cancer: A pooled analysis of 11 prospective cohort studies
Authors: Dianatinasab Mostafa , Wesselius Anke , Salehi‐Abargouei Amin , Yu Evan Y. W. , Fararouei Mohammad , Brinkman Maree , van den Brandt Piet , White Emily , Weiderpass Elisabete , Le Calvez‐Kelm Florence , Gunter Marc J. , Huybrechts Inge , Zeegers Maurice P. 
Published: February 2022

AbstractThe effects of fat intake from different dietary sources on bladder cancer (BC) risk remains unidentified. Therefore, the present study aimed to investigate the association between fat intakes and BC risk by merging world data on this topic. Data from 11 cohort studies in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) study, provided sufficient information on fat intake for a total of 2731 BC cases and 544 452 noncases, which yielded 5 400 168 person‐years of follow‐up. Hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were estimated using Cox‐regression models stratified on cohort. Analyses were adjusted for total energy intake in kilocalories, gender, smoking status (model‐1) and additionally for sugar and sugar products, beers, wine, dressing and plant‐based and fruits intakes (model‐2). Among women, an inverse association was observed between mono‐unsaturated fatty acids (MUFAs) and BC risk (HR comparing the highest with the lowest tertile: 0.73, 95% CI: 0.58‐0.93, P‐trend = .01). Overall, this preventative effect of MUFAs on BC risk was only observed for the nonmuscle invasive bladder cancer (NMIBC) subtype (HR: 0.69, 95% CI: 0.53‐0.91, P‐trend = .004). Among men, a higher intake of total cholesterol was associated with an increased BC risk (HR: 1.37, 95% CI: 1.16‐1.61, P‐trend = .01). No other significant associations were observed. This large prospective study adds new insights into the role of fat and oils in BC carcinogenesis, showing an inverse association between consumption of MUFAs and the development of BC among women and a direct association between higher intakes of dietary cholesterol and BC risk among men.
Alcohol intake trajectories during the life course and risk of alcohol‐related cancer: A prospective cohort study
Authors: Bassett Julie K. , MacInnis Robert J. , Yang Yi , Hodge Allison M. , Lynch Brigid M. , English Dallas R. , Giles Graham G. , Milne Roger L. , Jayasekara Harindra 
Published: February 2022

AbstractWe examined associations between sex‐specific alcohol intake trajectories and alcohol‐related cancer risk using data from 22 756 women and 15 701 men aged 40 to 69 years at baseline in the Melbourne Collaborative Cohort Study. Alcohol intake for 10‐year periods from age 20 until the decade encompassing recruitment, calculated using recalled beverage‐specific frequency and quantity, was used to estimate group‐based sex‐specific intake trajectories. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated for primary invasive alcohol‐related cancer (upper aerodigestive tract, breast, liver and colorectum). Three distinct alcohol intake trajectories for women (lifetime abstention, stable light, increasing moderate) and six for men (lifetime abstention, stable light, stable moderate, increasing heavy, early decreasing heavy, late decreasing heavy) were identified. 2303 incident alcohol‐related cancers were diagnosed during 485 525 person‐years in women and 789 during 303 218 person‐years in men. For men, compared with lifetime abstention, heavy intake (mean ≥ 60 g/day) at age 20 to 39 followed by either an early (from age 40 to 49) (early decreasing heavy; HR = 1.75, 95% CI: 1.25‐2.44) or late decrease (from age 60 to 69) (late decreasing heavy; HR = 1.94, 95% CI: 1.28‐2.93), and moderate intake (mean <60 g/day) at age 20 to 39 increasing to heavy intake in middle‐age (increasing heavy; HR = 1.45, 95% CI: 1.06‐1.97) were associated with increased risk of alcohol‐related cancer. For women, compared with lifetime abstention, increasing intake from age 20 (increasing moderate) was associated with increased alcohol‐related cancer risk (HR = 1.25, 95% CI: 1.06‐1.48). Similar associations were observed for colorectal (men) and breast cancer. Heavy drinking during early adulthood might increase cancer risk later in life.
Massive hemorrhagic ascites associated with extensive severe peritoneal endometriosis: A rare case report
Authors: Papageorgiou Dimitrios , Prantalos Panagiotis , Tzavoulis Dimitrios , Sgouros Spiros N. , Ivros Nikolaos , Papakonstantinou Katerina 
Published: February 2022

SynopsisThe contents of this page will be used as part of issue TOC only. It will not be published as part of main article.Massive hemorrhagic ascites may be a symptom of peritoneal endometriosis.