bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endocannabinoid levels in peripheral blood mononuclear cells of multiple sclerosis patients treated with dimethyl fumarate
Authors: Sánchez-Sanz Alicia , Posada-Ayala María , Sabín-Muñoz Julia , Fernández-Miranda Ismael , Aladro-Benito Yolanda , Álvarez-Lafuente Roberto , Royuela Ana , García-Hernández Ruth , la Fuente Ofir Rodríguez-De , Romero Julián , García-Merino Antonio , Sánchez-López Antonio José 
Published: November 2022

AbstractThe endocannabinoid system (ECS), a signalling network with immunomodulatory properties, is a potential therapeutic target in multiple sclerosis (MS). Dimethyl fumarate (DMF) is an approved drug for MS whose mechanism of action has not been fully elucidated; the possibility exists that its therapeutic effects could imply the ECS. With the aim of studying if DMF can modulate the ECS, the endocannabinoids 2-arachidonoylglycerol (2-AG), anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) were determined by liquid chromatography-mass spectrometry in peripheral blood mononuclear cells from 21 healthy donors (HD) and 32 MS patients at baseline and after 12 and 24 months of DMF treatment. MS patients presented lower levels of 2-AG and PEA compared to HD. 2-AG increased at 24 months, reaching HD levels. AEA and PEA remained stable at 12 and 24 months. OEA increased at 12 months and returned to initial levels at 24 months. Patients who achieved no evidence of disease activity (NEDA3) presented the same modulation over time as EDA3 patients. PEA was modulated differentially between females and males. Our results show that the ECS is dysregulated in MS patients. The increase in 2-AG and OEA during DMF treatment suggests a possible role of DMF in ECS modulation.
Vibration analysis of a high-pressure multistage centrifugal pump
Authors: Zhang Yan , Liu Jingting , Yang Xinzhen , Li Hongmin , Chen Songying , Lv Wei , Xu Wenchao , Zheng Jianping , Wang Dianyuan 
Published: November 2022

AbstractHigh-pressure multistage centrifugal pumps have been widely used in modern industry and required low vibration and noise. In this study, modal analysis of the rotor system of a seven-stage centrifugal pump was carried out numerically by introducing fluid force to ensure that the centrifugal pump would not resonate. A vibration test bench was established to investigate the characteristics with flow rates of 0.8Qd, 1.0Qd, and 1.2Qd, and the vibration data of ten measuring points were collected. The period of the vibration at the bearing was found to be around 20 ms and the period was related to the shaft frequency (SF) and the blade passing frequency (BPF). The vibration of the pump casing was mainly determined by the SF, two times the SF, and two times the BPF. Mechanical motion is the main factor causing pump vibration, and fluid unstable motion is also an important cause.
In-hive learning of specific mimic odours as a tool to enhance honey bee foraging and pollination activities in pear and apple crops
Authors: Farina Walter M. , Arenas Andrés , Díaz Paula C. , Susic Martin Cinthia , Corriale María J. 
Published: November 2022

AbstractThe areas devoted to agriculture that depend on pollinators have been sharply increased in the last decades with a concomitant growing global demand for pollination services. This forces to consider new strategies in pollinators’ management to improve their efficiency. To promote a precision pollination towards a specific crop, we developed two simple synthetic odorant mixtures that honey bees generalized with their respective natural floral scents of the crop. We chose two commercial crops for fruit production that often coexist in agricultural settings, the apple (Malus domesticus) and the pear trees (Pyrus communis). Feeding colonies with sucrose solution scented with the apple mimic (AM) or the pear mimic (PM) odour enabled the establishment of olfactory memories that can bias bees towards the flowers of these trees. Encompassing different experimental approaches, our results support the offering of scented food to improve foraging and pollination activities of honey bees. The circulation of AM-scented sucrose solution inside the hive promoted higher colony activity, probably associated with greater activity of nectar foragers. The offering of PM-scented sucrose solution did not increase colony activity but led to greater pollen collection, which is consistent with pear flowers offering mainly pollen as resources for the bees. Results obtained from apple and pear crops suggest that the offering of AM- and PM-scented sucrose solution increased fruit yields. This preliminary study highlights the role of in-hive olfactory learning to bias foraging preferences within pome fruit crops.
Preparation of high-quality YAG:Ce3+ ceramic phosphor by high-frequency induction heated press sintering methods
Authors: Kwon Seok Bin , Yoo Jung Hyeon , Choi Seung Hee , Na MinYoung , Kim Bo Young , Lee Seon Young , Jeong Ho-Jung , Kim Wan Ho , Park Seoung Hyok , Yoon Ho Shin , Kang Bong Kyun , Song Young Hyun , Yoon Dae Ho 
Published: November 2022

AbstractThis study investigates the characteristics of a ceramic phosphor (CP) for the converter of a high-power laser diode-based automobile headlamp synthesized by high-frequency induction heated press (HFP) sintering. The CP prepared by an HFP method exhibits remarkable optical properties that are comparable to spark plasma sintering. The effects of post-treatment process for controlling residual pores, as well as sintering temperature, sintering pressure and heating rate for optimization of the HFP sintering method, were studied. The HFP sintering process can be widely used in ceramics and lighting fields because it is designed relatively low cost compared to other techniques and exhibits excellent productivity.
Cannabinoid receptor 2 (Cb2r) mediates cannabinol (CBN) induced developmental defects in zebrafish
Authors: Amin Md Ruhul , Ahmed Kazi Tanveer , Ali Declan William 
Published: November 2022

AbstractOf the three primary cannabinoids in cannabis: Δ9-Tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD) and cannabinol (CBN), very little is known about the actions of CBN, the primary oxidative metabolite of THC. Our goal was to determine if CBN exposure during gastrulation alters embryonic development, and if so, does it act via the canonical cannabinoid receptors. Zebrafish embryos were exposed to CBN during gastrulation and exhibited dose-dependent malformations, increased mortality, decreased locomotion and a reduction in motor neuron branching. Moreover, larva showed a significant reduction in the response to sound stimuli. CBN exposure altered the development of hair cells associated with otic vesicles and the lateral line. Pharmacological block of Cb2rs with AM 630 or JTE 907 prevented many of the CBN-induced developmental defects, while block of Cb1rs with AM 251 or CP 945598 had little or no effect. Altogether we show that embryonic exposure to CBN results in alterations in embryonic growth, neuronal and hair cell development, physiology and behavior via Cb2r-mediated mechanisms.
Improving urban flood resilience via GDELT GKG analyses in China's Sponge Cities
Authors: Lu Xiaohui , Chan Faith Ka Shun , Li Nan , Chen Chuke , Chen Wei-Qiang , Chan Hing Kai 
Published: November 2022

AbstractUrban floods are the most severe disaster in most Chinese cities due to rapid urbanisation and climate challenges. Recently, media data analytics has become prominent in enhancing urban flood resilience. In this study, news media data from the GKG of the GDELT project was innovatively used to examine the pattern of news media responses towards urban flooding in China's Sponge City Programme (SCP) pilot cities. We find that public sentiments toward urban flood events have been more positive in SCP pilot cities from 2015 to 2021. News media responses towards urban floods exhibit strong seasonality, which is significantly connected with rainfall patterns. Most of the media articles were posted during the urban flood event. Finally, we suggest the opportunities and challenges in applying GKG data analytics and new technologies for urban flood resilience. The results can provide beneficial references to urban flood management strategies in China's Sponge Cities for associated policymakers and stakeholders.
Chronic prenatal delta-9-tetrahydrocannabinol exposure adversely impacts placental function and development in a rhesus macaque model
Authors: Roberts Victoria H. J. , Schabel Matthias C. , Boniface Emily R. , D’Mello Rahul J. , Morgan Terry K. , Terrobias Juanito Jose D. , Graham Jason A. , Borgelt Laura M. , Grant Kathleen A. , Sullivan Elinor L. , Lo Jamie O. 
Published: November 2022

AbstractCannabis use in pregnancy is associated with adverse perinatal outcomes, which are likely mediated by the placenta. However, the underlying mechanisms and specific vasoactive effects of cannabis on the placenta are unknown. Our objective was to determine the impact of chronic prenatal delta-tetrahydrocannabinol (THC, main psychoactive component of cannabis) exposure on placental function and development in a rhesus macaque model using advanced imaging. Animals were divided into two groups, control (CON, n = 5) and THC-exposed (THC, n = 5). THC-exposed animals received a THC edible daily pre-conception and throughout pregnancy. Animals underwent serial ultrasound and MRI at gestational days 85 (G85), G110, G135 and G155 (full term is ~ G168). Animals underwent cesarean delivery and placental collection at G155 for histologic and RNA-Seq analysis. THC-exposed pregnancies had significantly decreased amniotic fluid volume (p < 0.001), placental perfusion (p < 0.05), and fetal oxygen availability (p < 0.05), all indicators of placental insufficiency. Placental histological analysis demonstrated evidence of ischemic injury with microinfarctions present in THC-exposed animals only. Bulk RNA-seq demonstrated that THC alters the placental transcriptome and pathway analysis suggests dysregulated vasculature development and angiogenesis pathways. The longer-term consequences of these adverse placental findings are unknown, but they suggest that use of THC during pregnancy may deleteriously impact offspring development.
Performances of four Nucleic Acid Amplification Tests for the identification of SARS-CoV-2 in Ethiopia
Authors: Hailemariam Belete Woldesemayat , Zealiyas Kidist , Gutema Gadissa , Gebremicael Gebremedhin , Adane Sisay , Tadele Sisay , Tayachew Adamu , Araya Shambel , Desta Kassu 
Published: November 2022

AbstractSince Coronavirus Disease-2019 (COVID-19) outbreak was reported, many commercial Nucleic Acid Amplification Tests (NAAT) have been developed all over the world, and it has been the standard method. Even though several assays were rapidly developed and applied to laboratory diagnostic testing, the performance of these assays was not evaluated in different contexts. Thus, this study aimed to assess the performance of Abbott SARS-CoV-2, Daan Gene, BGI and Sansure Biotech assays by using Composite Reference Standard (CRS). The study was conducted at the Ethiopian Public Health Institute (EPHI) from December 1 to 30/2020. Of the 164 nasopharyngeal samples were extracted by using a QIAamp RNA mini kit and Abbott DNA sample preparation system. Out of 164 samples, 59.1% were positive and 40.9% were negative by CRS. Sansure Biotech positivity was significantly low compared to CRS (p < 0.05). The overall agreement of the four assays compared to CRS was 96.3–100%. The performance of the four assays had almost comparable diagnostic performance, except for a low positive rate of Sansure Biotech assay. Hence, Sansure Biotech assay [Research Use Only (RUO)] needs further verification on its use in Ethiopia. Finally an additional study should be considered for evaluating assays with respective manufacturer claims.
Green synthesis and characterization of UKMRC-8 rice husk-derived mesoporous silica nanoparticle for agricultural application
Authors: Dorairaj Deivaseeno , Govender Nisha , Zakaria Sarani , Wickneswari Ratnam 
Published: November 2022

AbstractAgriculture plays a crucial role in safeguarding food security, more so as the world population increases gradually. A productive agricultural system is supported by seed, soil, fertiliser and good management practices. Food productivity directly correlates to the generation of solid wastes and utilization of agrochemicals, both of which negatively impact the environment. The rice and paddy industry significantly adds to the growing menace of waste management. In low and middle-income countries, rice husk (RH) is an underutilized agro-waste discarded in landfills or burned in-situ. RH holds enormous potential in the development of value-added nanomaterials for agricultural applications. In this study, a simple and inexpensive sol–gel method is described to extract mesoporous silica nanoparticles (MSNs) from UKMRC8 RH using the bottom-up approach. RHs treated with hydrochloric acid were calcinated to obtain rice husk ash (RHA) with high silica purity (> 98% wt), as determined by the X-ray fluorescence analysis (XRF). Calcination at 650 °C for four hours in a box furnace yielded RHA that was devoid of metal impurities and organic matter. The X-ray diffraction pattern showed a broad peak at 2θ≈20–22 °C and was free from any other sharp peaks, indicating the amorphous property of the RHA. Scanning electron micrographs (SEM) showed clusters of spherically shaped uniform aggregates of silica nanoparticles (NPs) while transmission electron microscopy analysis indicated an average particle size of < 20 nm. Besides Energy Dispersive X-Ray which validated the chemical constituent of the silica NPs, the Fourier transform infrared (FT-IR) spectra showed peaks at 796.4 cm−1and 1052 cm−1corresponding to O–Si–O symmetric stretching vibration and O–Si–O asymmetric stretching, respectively. The Brunauer–Emmet–Teller (BET) analysis indicated an average pore size = 8.5 nm while the specific surface area and the pore volume were 300.2015 m2/g and 0.659078 cm3/g, respectively. In conclusion, agrowaste-derived MSN was synthesized using a simple and economical sol–gel method without the addition of surfactant reagents for controlled formation at the structural level. Owing to the MSNs’ excellent physical properties, the method established herein, could be used singly (without any modifications) for the functionalization of a myriad of agrochemicals.
Safety and efficacy of two ilioiliac tension band plates osteosynthesis of fragility fractures of the pelvis
Authors: Kułakowski Michał , Reichert Paweł , Elster Karol , Ślęczka Paweł , Oleksy Łukasz , Królikowska Aleksandra 
Published: November 2022

AbstractThe study retrospectively determined the efficacy and safety of fixation of the pelvis (FFP) fragility fractures type IV using two tension band ilioiliac locking compression plates. Forty-one patients with FFP were treated in 2017–2020. 16 patients with FFP type IV, unable to walk weight-bearing, were treated by fixation using two tension band ilioiliac locking compression plates without fixing the anterior ring. Preoperatively and one year postoperatively, the functional outcome and performance were assessed using Pelvic Discomfort Index (PDI) and Timed Up and Go (TUG) test. Pre- and postoperative hemoglobin level was evaluated. Operation time and intra-and postoperative complications were documented. One year postoperatively, an X-ray was taken. The arithmetic mean (x) and standard deviations (±) of quantitative variables were calculated. T-test for dependent samples was used for pre-and postoperative results comparison. The PDI improved (p < 0.001) from x = 81.42 ± 4.04 to x = 36.19 ± 15.58. Preoperatively none of the patients was able to perform the TUG test. Postoperatively, the result exceeded x = 13.13 ± 3.99 s. The operation lasted x = 42.80 ± 8.90 min. Hemoglobin decreased (p < 0.001) from 11.63 ± 1.11 to 9.07 ± 1.21 g/dL. No complications nor fixation loosening were noted. The study support fixation using two tension band ilioiliac locking compression plates as an efficient and safe treatment of the FFP type IV.
Macrophage polarity and wound age determination
Authors: Kuninaka Yumi , Ishida Yuko , Ishigami Akiko , Nosaka Mizuho , Matsuki Jumpei , Yasuda Haruki , Kofuna Ayumi , Kimura Akihiko , Furukawa Fukumi , Kondo Toshikazu 
Published: November 2022

AbstractWe investigated the dynamics of the gene expression of M1 and M2 macrophage markers during skin wound healing in mice. Expression of M1-macrophage markers, such as Il12a, Tnf, Il6, Il1b, and Nos2 was upregulated after wounding and peaked at 1 or 3 days after injury, and that of M2-macrophage markers such as Mrc1, Cd163, Ccl17, Arg, and Tgfb1, peaked at 6 days after injury. Consistent with these findings, using triple-color immunofluorescence analysis revealed that F4/80+CD80+ M1 macrophages were more abundant than F4/80+CD206+ M2 macrophages on day 3 in mouse wound specimens, and that M2 macrophages were prominently detected in day 6 wounds. For application in forensic practice, we examined macrophage polarization using human wound specimens. The average ratios of CD68+iNOS+ M1 macrophages to CD68+CD163+ M2 macrophages (M1/M2 ratios) were greater than 2.5 for the wounds aged 2–5 days. Out of 11 wounds aged 1–5 days, five samples had the M1/M2 ratios of > 3.0. These observations propose that the M1/M2 ratios of 3.0 would indicate a wound age of 1–5 days as the forensic opinion. This study showed that M1 and M2 macrophages in human skin wound might be a promising marker for wound age determination.
Protecting nonlocal quantum correlations in correlated squeezed generalized amplitude damping channel
Authors: Wang Shuo , Han Xin-Hong , Li Wei-Chen , Qian Tian , Fan Xuan , Xiao Ya , Gu Yong-Jian 
Published: November 2022

AbstractNonlocal quantum correlations, such as quantum entanglement, quantum steering, and Bell nonlocality, are crucial resources for quantum information tasks. How to protect these quantum resources from decoherence is one of the most urgent problems to be solved. Here, we investigate the evolution of these correlations in the correlated squeezed generalized amplitude damping (SGAD) channel and propose a scheme to protect them with weak measurement (WM) and quantum measurement reversal (QMR). Compared with the results of the uncorrelated SGAD channel, we find that when $$n=1$$

n
=
1

, correlation and squeezing effects can prolong the survival time of quantum entanglement, Bell nonlocality, and quantum steering by about 152 times, 207 times, and 10 times, respectively. In addition, local WM and QMR can effectively recover the disappeared nonlocal quantum correlations either in uncorrelated or completely correlated SGAD channels. Moreover, we find that these initial nonlocal quantum correlations could be drastically amplified under the correlated channel. And the steering direction can be flexibly manipulated either by changing the channel parameters or the strength of WM and QMR. These results not only make a step forward in suppressing decoherence and enhancing quantum correlation in noise channels, but also help to develop relevant practical applications.
Homogenization of the vertically stacked medium frequency magnetic metamaterials with multi-turn resonators
Authors: Steckiewicz Adam 
Published: November 2022

AbstractThe paper presents a homogenization method of the magnetic metamaterials, made of perpendicularly oriented resonators consisting of multi-turn planar coils. A resulting composite, in the form of parallel stripes with metamaterial cells, exhibits extraordinary properties in the medium frequency magnetic field, such as zero permeability. To identify an effective permeability of this metamaterial, two models were presented, i.e., a three-dimensional numerical model with current sheet approximation as well as Lorentz oscillator model, where individual coefficients are based on the lumped circuit parameters and directly related with a geometry of the unit cell. The accuracy of the second approach is improved by taking into account mutual inductances in a metamaterial grid. Then, a comparison is made with numerical model results to show adequacy of the adopted analytical attempt, and properties of this type of metamaterial are discussed. It is shown that discussed metamaterial structure can achieve negative permeability as well as its values, at identical resonant frequency, are dependent on number of turns of the planar coil.
Motion error analysis of a shield machine tool-changing robot based on a screw-vector method
Authors: Qian Wenxue , Song Shuai , Liu Kexin , Zeng Xianhai , Yin Xiaowei , Xie Liyang 
Published: November 2022

AbstractIndustrial robots are widely used in various industrial fields, such as handling and welding, due to their good repeat positioning accuracy. The motion error determines the absolute accuracy. For robot design, dimensional parameter errors and drive parameter errors, a mathematical model of a kinematic exponential product with error screws was proposed. The influence of different rod lengths and transmission errors on the accuracy of the end motion was analysed. A composite analysis method based on screw theory and vector method is proposed for the spatial deflection error of robot rotating joints with clearance. By using screw theory, a mathematical error model of the axial movement and spatial deflection of the joint gap was established. A mathematical model of joint space radial movement was established by using the three-dimensional vector method. Through numerical simulation, the position distribution law of the random error of the robot terminal in the workspace and the distribution of the plane projection density were obtained. By solving the attitude matrix, the distribution of each Euler angle error was obtained. A simulation test was carried out to verify the model's correctness. The calculation showed that the method is simple and correct, and the obtained error distribution characteristics are of great significance to improving robotic kinematic calibration accuracy and optimising the spatial position error distribution.
Protective water curtains as wave attenuators for blast-resistant tunnels
Authors: Mohammadi Payam Keshavarz Mirza , Khalilpour Seyed Hamed , Parsa Hasan , Sareh Pooya 
Published: November 2022

AbstractTunnels, as highly cost-demanding infrastructures which facilitate the transportation of people and goods, have been a target of terrorist attacks within the past few decades. The significance of the destructive impact of explosives on these structures has resulted in research on the development of blast-resistant design approaches. In this paper, water curtains are proposed as a blast-resistant system due to the established performance of water against explosives in free fields in previous studies as well as its capability to mitigate the potential incoming fire after an explosion. A parametric study was conducted for this purpose, considering the effects of curtain thickness, the distance of the curtain from the tunnel opening, and the amount of TNT charge. Accordingly, fifty-two finite element (FE) models were created in the FE package ABAQUS to investigate the performance of a water wall in a typical tunnel through the Eulerian approach to simulation. The water curtains had four different thicknesses and were located at three different distances from the reference point. TNT explosive charges were placed at the tunnel opening with four different masses. The thicker walls nearer to the tunnel opening were found to be more effective. However, the peak pressure reduction in all charges was in a desirable range of 53 to 80%. The parametric study also illustrated that the peak pressures were more sensitive to wall thickness rather than TNT charges mass and the wall distance from the explosives. We anticipate this preliminary study to be a starting point for the further development of the concept of water curtains for blast mitigation.