bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dekonvolution von Mikroskopiedaten bei niedrigem Signal-Rausch-Verhältnis
Authors: Woelk Lena-Marie , Diercks Björn-Philipp , Werner René 
Published: November 2022

AbstractFluorescence live cell microscopy is central to the analysis of inter- and intracellular signaling. However, analysis of highly dynamic, local processes requires high temporal and spatial resolution imaging, which is intrinsically linked to a low signal-to-noise ratio. To improve image quality after data acquisition, computational techniques, referred to as deconvolution, are being developed. Here, we discuss recent approaches in the areas of variational and deep learning image deconvolution.
Die Wirkungsweise des ZAP-Proteins bei Cytomegalievirus-Infektionen
Authors: Brinkmann Melanie M. 
Published: November 2022

AbstractThe repertoire of antiviral drugs and vaccines for many viral infections is astonishingly small. No licensed vaccine against human cytomegalovirus (HCMV) exists to protect risk groups. Thus, there is an urgent need to better understand the complex interplay between HCMV and its host and to identify effective intervention strategies. Recently, we identified the cellular ZAP protein as an important antiviral factor during HCMV infection: it binds specific viral transcripts and targets them for degradation. Further insights into the molecular details may improve targeted antiviral drug design.
Polyphosphat — ein unterschätztes Molekül
Authors: Jendrossek Dieter , Hildenbrand Jennie C. 
Published: November 2022

AbstractPolyphosphate (polyP) is an inorganic biopolymer ubiquitously present in all species. It has a variety of functions ranging from that of a reservoir for phosphorous in many microorganisms to functions in blood coagulation and plays a role in neurogenerative diseases in humans. Here, we provide a summary of the structure and functions that have been addressed to polyP in microorganisms.
Neue Methoden ermöglichen die Live-Beobachtung der Holzentstehung
Authors: Sass Annika , Schneider René 
Published: November 2022

AbstractTrees are among the largest organisms on earth. Their growth is supported by a specialized vascular system — the xylem, also known as wood — which conducts water from the root to the canopy and provides mechanical stability. The xylem is a network of dead hollow cells whose walls are extremely resilient and feature highly ordered spatial patterns. New optical methods allow real-time observation of wood formation, providing insight into how these walls function in transporting water.
Schallschalter: Photoschaltbare Reporter und Sensoren in der Optoakustik
Authors: Göllner Simon , Mishra Kanuj , Stiel Andre C. 
Published: November 2022

AbstractOptoacoustic imaging offers a unique combination of observation volume and achievable resolution in vivo. However, the use of transgene labeling agents has been impractical because their signal is low compared to the background of the tissue. Thus, detection was limited to large numbers of cells. We tackle this problem by using switchable agents — switching creates a signal modulation which allows to separate the labeled cells from the constant background — making it virtually invisible.
Bestimmung mikrobieller Gemeinschaften von Teichen in Stadt und Land
Authors: Ionescu Danny , Bizic Mina , Grossart Hans-Peter 
Published: November 2022

AbstractLand use intensification through intensive agriculture or urbanization were shown to affect biodiversity of different taxonomic or functional groups. We used deep amplicon sequencing of environmental DNA to investigate these effects on pond biodiversity in an area intensely used for agriculture, as well as in urban ponds. We revealed a biodiversity homogenization across ponds in arable fields, grasslands, and forests in the rural Uckermark, yet with significant differences to urban ponds in Berlin.
The Circular RNA Circ-ANAPC7 as a Biomarker for the Risk Stratification of Myelodysplastic Syndrome
Authors: Zhou Fang , Zhang Shuying , Huo Mei , Zhou Ying , Jiang Libo , Zhou Hong , Qu Ying 
Published: November 2022

AbstractTo assess the diagnostic value of circ-ANAPC7 expression levels in MDS and its risk stratification. This is a retrospective observational study. This study enrolled 125 patients diagnosed with MDS and divided them into five groups according to IPSS-R (very high group, 25; high group, 25; intermediate group, 25; low group, 25; and very low group, 25), and 25 patients with IDA were studied as control group from our bone marrow cell bank. Bone marrow cell were used as material in this study to measure the expression level of circ-ANAPC7 by qRT-PCR. An evaluation of diagnostic value was conducted using ROC curves. Circ-ANAPC7 expression levels were 5.623 ± 4.483, 28.396 ± 12.938, 91.867 ± 37.010, 202.525 ± 54.911, 337.633 ± 86.013, and 502.269 ± 98.410 from the control group to the very high group, respectively (p < 0.05). Circ-ANAPC7 expression was gradually upregulated with the risk stratification of MDS. The AUCs of circ-ANAPC7 were 0.973, 0.996, 0.951, 0.920, and 0.907 in the control group/very low group, very low group/low group, low group/intermediate group, intermediate group/high group, and high group/very high group, respectively. In this study, the expression level of circ-ANAPC7 was found to be a promising biomarker for MDS. It may be added to the scoring system to better identify risk groups.
Development and prospects of garnet ceramic scintillators: A review
Authors: Zhu Danyang , Nikl Martin , Chewpraditkul Weerapong , Li Jiang 
Published: November 2022

AbstractGarnet ceramic scintillators are a class of inorganic scintillation materials with excellent overall performance. The flexibility of cation substitution in different lattice positions leads to tunable and versatile properties and a wide range of applications. This paper starts with an overview of the development history of the inorganic scintillation materials, followed by a description of major preparation methods and characterization of garnet scintillation ceramics. Great progress obtained in recent years consisting in applying the band-gap and defect engineering strategies to the garnet scintillation ceramics is reviewed. Finally, the respective problems in the preparation and performance of multicomponent garnet single crystals and ceramics and the effective solutions are discussed. The garnet scintillation ceramics with the highest application potential are summarized, and the future development directions are proposed.
Becoming a Parent
Authors: McMahon Catherine A. 
Published: November 2022

The contexts for becoming a parent are ever-changing, bringing new opportunities and new challenges. Becoming a Parent examines the transition to parenthood from diverse perspectives – it is about becoming, rather than being a parent. Drawing on a large body of theory and research, the book explores universal psychological journeys as well as the specific challenges faced by those whose pathways to parenthood are non-traditional or medically complicated. It also examines the unprecedented reproductive choices in contemporary society and provides a comprehensive overview of the personal and social impact of reproductive technologies. Pregnancy, childbirth, and early parenthood (the so-called 'fourth trimester') are discussed in detail and illustrated with case anecdotes and personal stories of people with 'high-risk' pregnancies, fathers as well as mothers, adoptive parents, and LGBTQ as well as heterosexual adults. It concludes with social and policy initiatives that can better support positive adaptation during this crucial life transition.
A Quality Assessment of Aquaporin-4 & Myelin Oligodendrocyte Glycoprotein Antibody Testing
Authors: Krett Jonathan D. , Fritzler Marvin J. , Alikhani Katayoun , Burton Jodie M. 
Published: November 2022

ABSTRACT:Background:Accurate anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody assays are needed to effectively diagnose neuromyelitis optica spectrum disorder and MOG antibody-associated disease. A proportion of patients at our centre have been tested for anti-AQP4 and anti-MOG autoantibodies locally, followed by an outsourced test as part of real-world practice. Outsourced testing is costly and of unproven utility. We conducted a quality improvement project to determine the value of outsourced testing for anti-AQP4 and anti-MOG autoantibodies.Methods:All patients seen by Calgary neurological services who underwent cell-based testing for anti-AQP4 and/or anti-MOG autoantibodies at both MitogenDx (Calgary, AB) and Mayo Clinic Laboratories (Rochester, MN, USA) between 2016 and 2020 were identified from a provincial database. The interlaboratory concordance was calculated by pairing within-subject results collected no more than 365 days apart. Retrospective chart review was done for subjects with discordant results to determine features associated with discordance and use of outsourced testing.Results:Fifty-seven anti-AQP4 and 46 anti-MOG test pairs from January 2016 to July 2020 were analyzed. Concordant tests pairs comprised 54/57 (94.7%, 95%CI 88.9–100.0%) anti-AQP4 and 41/46 (89.1%, 95%CI 80.1–98.1%) anti-MOG results. Discordant anti-AQP4 pairs included two local weak positives (negative when outsourced) and one local negative (positive when outsourced). Discordant anti-MOG pairs were all due to local weak positives (negative when outsourced).Conclusion:Interlaboratory discordant results for cell-based testing of anti-AQP4 autoantibodies were rare. Local anti-MOG weak positive results were associated with discordance, highlighting the need for cautious interpretation based on the clinical context. Our findings may reduce redundant outsourced testing.
The Epistemology of the South, Coloniality of Gender, and Latin American Feminism
Authors: Mendoza Breny , Paredes Grijalva Daniela 
Published: November 2022

AbstractThis article provides a Latin American feminist critique of early decolonial theories focusing on the work of Aníbal Quijano and Enrique Dussel. Although decolonial theorists refer to Chicana feminist scholarship in their work, the work of Latin American feminists is ignored. However, the author argues that Chicana feminist theory cannot stand in for Latin American feminist theory because “lo latinoamericano” gets lost in translation. Latin American feminists must do their own theoretical work. Central to the critique of the use of gender in decolonial theory is an analysis of the social pacts among white capitalists and white working-class men that not only exclude white women but make citizenship and democracy impossible for men and women of color in the metropolis as well as in the colony. By revealing the nexus between gender, race, and democracy, not only is the coloniality of gender apparent, but also the coloniality of democracy.
An Autonomous-Feminist Statement: The Challenge for Developing Community in La Casa de las Diferencias
Authors: Autónomo Encuentro Feminista , Castillo Espinosa Lia 
Published: November 2022

AbstractThis autonomous-feminist statement is a collective work born from a gathering at the Autonomous Feminist Encounter [Encuentro Feminista Autónomo] in Mexico City in 2009. This piece gives a historical review of so-called autonomous feminism in Latin America and poses a definition and vision of its praxis, taking into account the socio-political-economic context in Latin America in the early 2000s. This article also recognizes feminist groups that started the critique of hegemonic feminist praxis in the region.
The Woman and Her Obscure Versions
Authors: Rodríguez Moreno Celenis , Montelongo González Alejandro 
Published: November 2022

AbstractThe objective of this article is to analyze the production of the subject Woman by reviewing some practices, discourses, and technologies promoted by the state, the church, and elites. It is important to emphasize that in most research about women or femininity, female subjectivity appears tightly linked to sexual difference. However, in this work I want to show that the notion of Woman is co-determined by race and class. The experience characteristic of such representation was possible only for a small group of white and bourgeois women. Others—Indian, black, and mestiza “women”—could hardly account for a social experience comparable to the Western narrative about woman. Nevertheless, processes of homogenization allow these others to be classified and disciplined according to the gender norm, yet without altering the prejudices and inequalities produced by the prevailing racist and classist system, which implies the production of other female subjectivities, of other “women.”
The Flaw in Formalist Accounts of Circumvention Tourism
Authors: Shaw Joshua 
Published: November 2022

AbstractCircumvention tourism is a form of medical tourism that occurs when individuals travel abroad to receive treatments that are a prohibited in their home county but permitted in a destination country. This paper explores this question: Should individuals be punished by their home countries for engaging in circumvention tourism? Guido Pennings, Richard Huxtable, and I. Glenn Cohen have all argued for what I call “formalist accounts” of circumvention tourism. That is, they try to show that certain types of circumvention tourism should or should not be punished in principle. Against them, I show that questions about circumvention tourism’s punishability cannot be answered in the abstract. Whether individuals should be punished depends too much on the prima facie morality of the treatments being performed and the prohibitions being circumvented.
The Role of District Magnitude in When Women Represent Women
Authors: Crisp Brian F. , Cunha Silva Patrick 
Published: November 2022

AbstractLegislators are likely to substantively represent groups to which they belong or with which they have some particular affinity. However, there are electoral systems that diminish this tendency and systems that promote it. More precisely, as district magnitude increases, representatives will be freer to focus on issues that are not decisive of vote choice for most voters. In this letter, we use a case of electoral reform and the nature of the post-reform chamber (Chile's Chamber of Deputies) to test whether increasing district magnitude makes it more likely that women will focus on women's issues. A series of tests on multiple sets of observations show robust results for the conclusion that as the number of candidates elected in a district increases, elected women become more likely to pursue women's issues.
Effect of experimental stress and cortisol release induced by ACTH administration on expression of key genes related to milk synthesis and apoptosis during mammary involution of Saanen goats
Authors: Manica Emanuel , Silva Priscila dos Santos , Merighe Giovana Krempel Fonseca , de Oliveira Sandra Aparecida , Bomfim Gabriela Facholi , Negrão João Alberto 
Published: November 2022

AbstractThis research paper addresses the hypothesis that stress, induced by ACTH administration and cortisol release increases somatic cell count (SCC) in mammary secretion, and improves the effectiveness of dry off in goats. We report indicators of milk synthesis and mammary gland involution during dry off. Thirty Saanen goats were subjected to abrupt dry off and treatments: (1) ACTH administration (ACTH) or (2) placebo (Control) on days 1, 3, 6, 9, 12, 15, 30, and 60 of dry off. The expression of target genes in mammary tissue that are related to milk synthesis and cell survival such as insulin-like growth factor 1 receptor (IGF1R), phosphatidylinositol-3-kinase (PIK3CA), protein kinase B (AKT1) and mechanistic target of rapamycin (MTOR), casein (CSN2), lactalbumin (LALBA) and lactoferrin (LF) were evaluated, and plasma cortisol concentration, SCC, leucocyte count, and microbiological analyses in milk and mammary secretions were assessed. ACTH significantly downregulated the expression of IGF1R and upregulated the expression of PIK3CA in mammary tissue, increased lactoferrin concentration and SCC, and changed immune cell levels in mammary secretions compared to Control. Furthermore, ACTH administration increased the percentage of dry goats compared to the Control (73 vs. 46%, respectively). We conclude that the effect of stress via ACTH administration and cortisol release accelerated mammary involution during the early dry-off period.
Exploration and arrangement in physical and social worlds
Authors: Oatley Keith 
Published: November 2022

Abstract
Fiction involves exploring imaginative arrangements of places and characters: elements that can be recognized by readers. In childhood, exploration occurs from a safe home base of a caregiver; fiction enables a comparable basis. Physical elements in fiction are settings. More important are social explorations: transactions with characters that can include transformation. This is illustrated by Alice's Adventures in Wonderland.
The allure of the unknown in a tamed, mapped, and homogenized world
Authors: Gabora Liane , Gomez Isabel 
Published: November 2022

Abstract
As the physical world becomes tamed and mapped out, opportunities to experience the unknown become rarer; imaginary worlds provide a much-needed sense of potentiality. Potentiality is central to the Self-Other Re-organization theory of cultural evolution, which postulates that creativity fuels cumulative cultural change. We point to evidence that fear affects, not the magnitude of exploration, but how cautiously it proceeds.
Does progressive aphantasia exist? The hypothetical role of aphantasia in the diagnosis of neurodegenerative diseases
Authors: Sitek Emilia J. , Konieczna Seweryna 
Published: November 2022

Abstract
Aphantasia is a heterogeneous neuropsychological syndrome consisting of the inability to create mental images. We argue that its progressive form may be a harbinger of dementia. Aphantasia may manifest as the inability to create any mental images or to create complex scenes, inability to spontaneously initiate generation of mental images, and/or inability to visualize a sequence of events.
Assessment of L2 intelligibility: Comparing L1 listeners and automatic speech recognition
Authors: Inceoglu Solène , Chen Wen-Hsin , Lim Hyojung 
Published: November 2022

AbstractAn increasing number of studies are exploring the benefits of automatic speech recognition (ASR)–based dictation programs for second language (L2) pronunciation learning (e.g. Chen, Inceoglu & Lim, 2020; Liakin, Cardoso & Liakina, 2015; McCrocklin, 2019), but how ASR recognizes accented speech and the nature of the feedback it provides to language learners is still largely under-researched. The current study explores whether the intelligibility of L2 speakers differs when assessed by native (L1) listeners versus ASR technology, and reports on the types of intelligibility issues encountered by the two groups. Twelve L1 listeners of English transcribed 48 isolated words targeting the /ɪ-i/ and /æ-ε/ contrasts and 24 short sentences that four Taiwanese intermediate learners of English had produced using Google’s ASR dictation system. Overall, the results revealed lower intelligibility scores for the word task (ASR: 40.81%, L1 listeners: 38.62%) than the sentence task (ASR: 75.52%, L1 listeners: 83.88%), and highlighted strong similarities in the error types – and their proportions – identified by ASR and the L1 listeners. However, despite similar recognition scores, correlations indicated that the ASR recognition of the L2 speakers’ oral productions mirrored the L1 listeners’ judgments of intelligibility in the word and sentence tasks for only one speaker, with significant positive correlations for one additional speaker in each task. This suggests that the extent to which ASR approaches L1 listeners at recognizing accented speech may depend on individual speakers and the type of oral speech.
Ethical Issues Regarding Nonsubjective Psychedelics as Standard of Care
Authors: Yaden David B. , Earp Brian D. , Griffiths Roland R. 
Published: November 2022

AbstractEvidence suggests that psychedelics bring about their therapeutic outcomes in part through the subjective or qualitative effects they engender and how the individual interprets the resulting experiences. However, psychedelics are contraindicated for individuals who have been diagnosed with certain mental illnesses, on the grounds that these subjective effects may be disturbing or otherwise counter-therapeutic. Substantial resources are therefore currently being devoted to creating psychedelic substances that produce many of the same biological changes as psychedelics, but without their characteristic subjective effects. In this article, we consider ethical issues arising from the prospect of such potential “nonsubjective” psychedelics. We are broadly supportive of efforts to produce such substances for both scientific and clinical reasons. However, we argue that such nonsubjective psychedelics should be reserved for those special cases in which the subjective effects of psychedelics are specifically contraindicated, whereas classic psychedelics that affect subjective experience should be considered the default and standard of care. After reviewing evidence regarding the subjective effects of psychedelics, we raise a number of ethical concerns around the prospect of withholding such typically positive, meaningful, and therapeutic experiences from most patients.
Complexity, Not Severity: Reinterpreting the Sliding Scale of Capacity
Authors: Mellgard George , Gligorov Nada 
Published: November 2022

AbstractIn this article, we focus on the definition and application of the sliding scale of capacity. We show that the current interpretations of the sliding scale confound distinct features of the medical decision, such as its urgency, its severity, or its complexity, that do not always covary. We propose that the threshold for assessing capacity should be adjusted based solely on the cognitive complexity of the decision at hand. We further suggest that the complexity of a decision should be identified based on a patient’s particular cognitive deficits. We utilize the current research on the types of deficits that characterize amnestic dementias and examine which types of medical decisions might be most complex for patients with that type of dementia. We conclude that applying the sliding scale based on individualized judgments of cognitive complexity will improve accuracy of assessment of capacity and enable capable patients to participate in medical decision making.