bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Adnexa Foreign Body: A Piece of Mica from a Broken Helmet
Authors: Hapsari Windya Tri , Doemilah Ratna 
Published: December 2022

Introduction: Adnexa foreign body is one of the classifications of extraocular foreign body. Visual prognosis depends on the zone of injury, type, and size of the foreign body and subsequent complications. Case presentation: A 5-year-old girl came to the outpatient clinic with her parent with chief complaints of swelling and pain in the left lower eyelid after a motorcycle accident five months ago. The patient was hit by a piece of mica from a broken helmet in her left eye. The patient complained that her left eye was red, swollen, and difficult to be opened. She was referred to one of the ophthalmologists in Jember and then referred to Dr. Soetomo Hospital for the diagnosis of a conjunctival tumor in the left eye. The visual acuity of both eyes was 5/5. There was conjunctival hyperemia and a foreign body of glass or mica in the inferior fornix. CT scan imaging revealed corpus alienum with the size of 1.05 x 0.5 x 2.1 cm in the subcutan of the left inferior eyelid and ciliary body with swollen tissue around the corpus alienum. The patient was planning to extract the foreign body. Discussion: Definitive management was surgical. Corpus alienum extraction depends on the composition and size of the object. Adnexa foreign body management in the fornix was challenging because of the narrowing of the operating space. It was essential to identify the material type of the foreign body and the mechanism of injury because it impacts the step of the technique. Conclusion: Adnexa foreign body is one of the emergency cases in ophthalmology. The extraction technique depends on the object's composition and size because it impacts the step of the operation technique.
Pengembangan E-LKPD Berbasis Etnomatematika Melalui Kerajinan Anyaman pada Materi Lingkaran
Authors: Khadijah Siti , Fajriah Noor , Budiarti Indah 
Published: December 2022

Kurangnya minat siswa dalam pembelajaran matematika diakibatkan dari faktor internal ataupun eksternal seperti metode pembelajaran yang kurang bervariasi, dan materi yang digunakan kurang menarik. Cara yang dapat dilakukan untuk mengatasi hal tersebut dengan bahan ajar yang menarik dan interaktif salah satunya pengembangan LKPD dalam bentuk elektronik yang dikaitkan dengan kearifan budaya lokal Kalimantan Selatan. Penelitian ini bertujuan untuk mengetahui proses dan juga hasil dari pengembangan E-LKPD pada materi lingkaran berbasis etnomatematika melalui pendekatan saintifik untuk SMP/MTs yang valid. Metode Research and Development atau R&D adalah metode yang dipakai pada penelitian ini, dan dengan model 4D sampai pada tahap pengembangan saja. Teknik analisis data yang digunakan pada penelitian ini didasarkan pada uji validitas yang diperoleh melalui analisis secara kuantitatif dan kualitatif dari lembar validasi pada tahap develop yang dilakukan oleh tiga ahli. Menurut skor yang diberikan oleh ketiga ahli, didapatkan skor rata-rata 3,51, artinya E-LKPD termasuk kategori valid dan dapat digunakan dalam pembelajaran matematika. The lack of student interest in learning mathematics is caused by internal or external factors such as learning methods that are less varied and the material used could be more attractive. One way that can be done to overcome this is with interesting and interactive teaching materials, one of which is the development of the student worksheet in electronic form that is linked to the local cultural wisdom of South Kalimantan. This study aims to determine the process and results of developing an E-student worksheet on ethnomathematical-based circle material through a valid scientific approach for SMP/MTs. The Research and Development or R&D method is used in this research, and the 4D model only reaches the development stage. The data analysis technique used in this study was based on the validity test obtained through quantitative and qualitative analysis of the validation sheet at the development stage carried out by three experts. According to the scores given by the three experts, an average score of 3.51 was obtained, meaning that the E-LKPD was included in the valid category and could be used in learning mathematics.
Insights from the Alabama Hills into Mesozoic Magmatism and Tectonics in Eastern California
Authors: Frazer Ryan E. , Gaynor Sean P. , Coleman Drew S. , Wenner Jennifer M. 
Published: December 2022

Abstract
New zircon U-Pb ages for the Alabama Hills Granite in Owens Valley, eastern California, range from 103 to 102 Ma, nearly 20 Ma older than previously published zircon ages. The data preclude previously implied links between the pluton and the adjacent Late Cretaceous Mount Whitney Intrusive Suite. Geochronologic and isotopic data indicate a connection between the Alabama Hills Granite and leucogranites to the northwest on the Sierra Nevada crest, as well as a pluton to the southeast in the Coso Range. We refer to these units as the Kearsarge plutons. The suite was intruded from 103 to 100.5 Ma with S87r/S86ri=0.7045 to 0.7060 and εNdi=−2.4 to -4.5 and has distinctive enrichments in high field strength, middle, and heavy rare earth elements, as well as negative Eu anomalies and high Y/Sr. We suggest the Alabama Hills block could not have moved more than 10 km dextrally relative to the Sierra Nevada batholith since the Middle Jurassic and is thus a suitable piercing point for offsets across Owens Valley. The Kearsarge plutons, like other markers on either side of Owens Valley, support approximately 65–75 km of dextral offset across the valley. The suite’s location east of other middle Cretaceous suites, coupled with its mantle-like isotope geochemistry, suggests it could represent backarc magmatism, perhaps controlled by preexisting shear zones or fractures.
A Successful Implementation of a Cost-Effective Well Intervention Using Gas Injection Technique in Producing Wells to Increase Oil Production in Mature Fields
Authors: Nascimento Leonardo Severiano Guedes , Pinto Elida Natasche de Medeiros Gurgel , Dos Santos Felipe Pergentino , Leite Gustavo Brandao Monteiro , Bezerra Matheus De Freitas , Cardoso Antonio Augusto Cubeiro , Loureiro Gustavo Leandro 
Published: December 2022

Abstract
The objective of this paper is to present a successful and cost-effective technique applied in a producing well located in a Mature Field offshore Brazil. The Gas Injection technique increased the productivity index and rates temporarily in sandstones reservoirs suffering from compaction and fines migration, causing solids to deposit and build up in completion screens. It also increases temperature profile from the well, assisting in flow assurance issues and minimizing possibility of dynamic hydrate formation. The gas injection operation is performed periodically, shutting the well and injecting gas - through gas lift lines - into the wellbore passing by the completion screens. Due to the risk of hydrate formation, an inhibitor is injected to avoid this issue in both wellbore and jumper flowlines. The operation comprises of an injection target at controlled rate of 4 MMSCFD. Once performed, the well is brought back online. It is then evaluated the well performance aligned to a test separator, comparing current production figures to reference values prior to the gas injection operation. The mechanism of gas being injected into the wellbore will push the fines away from the completion screens, restoring the flow area. The results have shown an average increase of 21% of oil production with a lasting effect of ten days until it reaches same production figures as pre-injection reference figures. It has also been observed an increase of the well temperature profile (bottom hole and wellhead temperature transmitters), assisting in preventing dynamic hydrate formation and minimizing operational costs reducing continuous hydrate inhibitor injection rates for this well. Integrity risks have been considered and assessed with regards to reservoir, well completion and subsea system, with no major risks being identified. This technique presents a way to obtain production increase with no major intervention or downtime, at a low cost, extending the life cycle of producing wells in mature fields using means already available (in fields that use gas lift as artificial lift system). Secondarily, it will also assist in flow assurance issues with temperature increase and preventing dynamic hydrate formation.
Grow Newtonian rigid inertia into parameter repetitiveness memory equivalent bio-inertia over the “super-simultaneousness” of quantum mechanics for growth turnover selection inheritance
Authors: Lai Yi Yu 
Published: December 2022

Abstract
Inversion energy is defined as parameter-against-gravity-internal-fluctuation, the non-simultaneousness in correlated internal fluctuations is quantizing time. Modified Newtonian Three Laws are, first: 𝑑 𝑑𝑥 cosx =−𝑠𝑖𝑛𝑥, 𝑑 𝑑𝑥 sinx = 𝑐𝑜𝑠𝑥; second: 𝐹⃗ = 𝑚 ∙ 𝑎⃗ + |𝑚𝑔⃗ ∫ 𝑡𝑔𝜃 ⋅ 𝑑𝜃 ⟩ ↿⇂; third: Wavelength = 2 𝑛 L, frequency = n𝑓0 . Bio-systems are topological spaces that can process input objects into inversion energy for entropy-control by repetitiveness memory, the capability of equivalent procured inversion energy with memorized trigonometric repetitiveness by quantizing time is bio-inertia. Evolution grows the trigonometric folding equivalent capacity of a topological space. Schrödinger equation has only quantized energy but hasn’t quantized time thus inducing quantum collapse. We then write the gravitational growth turnover equation as 𝑯̂𝜓 = 𝑬𝜓 + ∑ | cos( 1 𝑛 𝑛 𝑥)⟩ to reverse super-simultaneous quantum collapse for lifespan. Originating from elastic quantum scale differences between Planck regions and surface tension regions, bio quantum duality grows in vivo cross folded-surface tension region flow. Life relies on trigonometric negentropy procured from elastic entropy generation ground states and physically inherit by bio quantum growth turnover selection.
Plant consumption in Áspero, Peru, during the Initial Formative Period (3000-1800 BCE): New evidence from starch grain trapped in human dental calculus.
Authors: Yseki Marco , Pezo-Lanfranco Luis , Machacuay Marco , Novoa Pedro , Shady Ruth 
Published: December 2022

Abstract
The objective of this research is to determine the dietary relevance of the plants consumed by the inhabitants of Aspero, an urban center on the coast of the Supe Valley, Peru. For this purpose, starch grains trapped in the human dental calculus of eleven individuals were recovered. Additionally, the results of one individual recovered from the Sacred City of Caral, located in the interior of Supe Valley, are presented. The high number of starch grains recovered from sweet potato and squash possibly indicates a frequent consumption of these starchy plant foods by the inhabitants of Áspero. These results are consistent with previously published isotopic analyses indicating that C3 plants were an important part of the diet of the Áspero inhabitants. Although our results indicate that there was maize consumption at Áspero and Sacred City of Caral, our results and previous isotopic analyses performed on the same individuals, show that maize was not fundamental in the diet of the origins of the civilization. Finally, based on the damage patterns in starch grains, we report the first direct evidence of possible maize fermentation during the Initial Formative Period. Considering the economic and ritual importance of fermented beverage consumption in the ethnohistoric and archaeological record of later periods, this finding could have critical implications for understanding the process of social complexity in the region.
Commercial Health Insurance, Catastrophic Medical Expenditures and Resident Income Inequality
Authors: Zhao Jian guo , Shi Long , zhou deshui 
Published: December 2022

Abstract

Objective:Commercial health insurance is an important link in both establishing a multi-layer social security system and as a means of facilitating social fairness and the distribution of wealth. This study evaluates the influence of commercial health insurance on resident income inequality and analyses its influencing mechanism from the perspective of catastrophic medical expenditures.Method:7,404 research samples from the China General Social survey (CGSS) hybrid databases for the years 2015, 2017, and 2018 were analysed. The influence of commercial health insurance on resident income inequality and its mechanism of action were tested through an OLS regression model and mediating effect model.Results:Commercial health insurance inhibits resident income inequality significantly, especially for respondents below 60 years of age in rural areas and western China. Commercial health insurance was found to relieve resident income inequality by lowering the occurrence rate of catastrophic medical expenditures.Conclusions:The complementary advantages of government and market mechanisms should be developed fully to accelerate the coordinated development of basic medical insurance and commercial medical insurance. Moreover, considerations should be given to differences among groups. It is suggested that the public should be relieved of the financial burden of major and critical diseases, that the differences in residents’ income levels should be narrowed, and that the distribution of wealth should be facilitated.
Comparison of the Effects of Empagliflozin and Sotagliflozin on a Zebrafish Diabetic Heart Failure with Reduced Ejection Fraction Model
Authors: Lee Hae-Young , Kim Inho , Cho Hyun-Jai , Lim Soo , Seok Seung Hyeok 
Published: December 2022

AbstractThe sodium-glucose co-transporter 2 (SGLT2) inhibitor, empagliflozin (EMPA), and dual SGLT1/2 inhibitor, sotagliflozin (SOTA) are emerging as heart failure (HF) medications beyond their glucose-lowering-effects in diabetes mellitus (DM). However, the precise mechanism underlying this cardioprotective effect has not yet been elucidated. Here, we evaluated the effects of EMPA and SOTA in a DM combined with HF with reduced ejection fraction (DM-HFrEF) zebrafish model. The myocardial contractile functions and motility were evaluated by MicroZebraLab and DanioVision, respectively. The structural binding and modulating effect of the two medications on sodium-hydrogen exchanger 1 (NHE1) was evaluatedin silicoandin vitro. DM-HFrEF zebrafish showed impaired cardiac contractility and decreased motility and survival, all of which were improved by 5 µM EMPA or SOTA treatment. However, the 25 µM SOTA treatment group had worse survival rates and less motility preservation than the EMPA treatment group with the same concentration, and an epicardial edema and uninflated swim bladder were observed. We evaluated the structural binding and modulation effect of the two medications on NHE1 bothin silicoandin vitro. The SOTA, EMPA and cariporide (CARI) showed a similar structural binding affinity to NHE1. In addition, EMPA, SOTA, and CARI effectively reduced intracellular H+, Na+and Ca2+changes through the inhibition of NHE1 activity. These findings suggest that both EMPA and SOTA exert cardioprotective effect in DM-HFrEF zebrafish model through the inhibition of NHE1 activity. In addition, despite the similar cardioprotective effects of both drugs, SOTA may be less effective than EMPA at high concentrations.
High dimensional feature selection using informative distance measures: Application to COVID-19 severity prediction
Authors: Wild Romina , Sozio Emanuela , Margiotta Riccardo Giuseppe , Dellai Fabiana , Acquasanta Angela , Ben Fabio Del , Tascini Carlo , Curcio Francesco , Laio Alessandro 
Published: December 2022

Abstract
Clinical data bases typically include, for each patient, many heterogeneous features, for example blood exams, the clinical history before the onset of the disease, the evolution of the symptoms, the results of imaging exams, and many others. Using subsets of these features, one can measure the similarity between two patients in several different manners. We here propose to exploit a recently developed statistical approach, the information imbalance, to compare these different similarity measures, and quantify their relative information content. We apply this approach to a data set of ~ 1,300 COVID-19 patients in Udine hospital before October 2021. Using this approach we find (asymmetric) relationships between single features and systematically compare subsets of up to 20 different features as COVID-19 severity predictors. The identified features can be measured at the moment of the admission of the patient and, if used in combination, are maximally informative of the clinical fate and of the severity of the disease. The approach can be used also if the features are available only for a fraction of the patients and, importantly, is able to select automatically features with small inter-feature correlation.
Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy
Authors: Kim Christine , Loftus John P , Huson Heather J. 
Published: December 2022

Abstract
Background
Alanine aminotransferase (ALT) is commonly used as a marker of hepatocellular injury. Increased serum ALT activity due to hepatocyte injury occurs in copper-associated hepatopathy (CuCH) and other necroinflammatory liver conditions. Blood ALT concentrations are frequently used to monitor therapy in cases of CuCH. Low serum ALT activities have been associated with an allele at the CFA13 locus.
Case presentation:
A 9-year-old female spayed Siberian Husky was diagnosed with CuCH (hepatic copper dry weight 2680 µg/g [normal, 120–400 µg/g; toxic, > 1500 µg/g]) and a normal ALT (78 U/L; reference range, 10–125 U/L). Mild hepatocellular necrosis was evident histologically. Genetic testing (Embark) revealed that the dog was heterozygous for the low ALT activity gene allele.
Conclusions
This case report illustrates the clinical implications for diagnosing and managing necroinflammatory liver disease such as CuCH in dogs with a low ALT activity genotype.
Poor subjective sleep reported by people living with HIV is associated with impaired working memory
Authors: Zahr Natalie M. , Sullivan Edith V. , Pfefferbaum Adolf 
Published: December 2022

Abstract
Background. Poor sleep can undermine the health of people in general and may be especially disruptive to those with chronic conditions including HIV infection.
Methods. Here, clinically well-described people living with HIV infection [PLWH] (74 men, 35 women) and healthy control (38 men, 35 women) participants were administered the Pittsburgh Sleep Quality Index (PSQI), which is a validated measure of subjective sleep with a global score ≥ 5 able to distinguish good from poor sleepers. In addition, participants completed neuropsychological tests assessing executive functioning, working memory, and learning and memory.
Results. PLWH (6.8±3.7) had higher global PSQI scores than those of healthy controls (4.1±2.8): 39.7% of uninfected controls and 68.8% of PLWH had a PSQI ≥ 5 indicative of poor sleep. There were no relations between the global PSQI score and any evaluated variables among healthy-control individuals or with demographic or HIV-related variables in PLWH. Instead, a higher global PSQI score among PLWH was associated with worse “Quality of Life” measures including scores on the Global Assessment of Functioning (GAF, p = .0007), the Medical Outcomes Study survey (21-item short form, SF-21, p < .0001), and Activities of Daily Living-Instrumental (ADL-I, p = .0041); and more depressive symptoms as determined by the Beck Depression Index (BDI, p < .0001). Further, in PLWH, a higher global PSQI score was associated with poor performance on a working memory task, the digit backward span (p = .0036). In PLWH, the 5 variables together explained 32.3% of the global PSQI score variance; only 3 variables – the SF-21, BDI, and digit backward scores – explained 30.6% of the variance.
Conclusions. To the extent that poor subjective sleep contributes to impaired working memory in HIV, we speculate that this impairment may be ameliorated by improved sleep health.
Hazardous exogenous geological processes in the mountains under the pressure of human activity: 15-year observations from a natural landscape to a large ski resort
Authors: Derkacheva Anna , Golosov Valentin , Shvarev Sergey , Kharchenko Sergey 
Published: December 2022

Abstract
Recent studies reveal an ongoing world-wide increase in a number of slope instability manifestations and their positive correlation with human activity. The latter involves construction activity as one of the most common trigger or susceptibility raising factors. In this study we conduct a detailed analysis of an extensive and rapid transformation of a forest-covered mountain landscape and its response. The study area is a mountain sport cluster of the Winter Olympic Games-2014, which developed from scratch to a large tourist resort in just a few years. A time-series of aerospace images and elevation models were used for a comprehensive mapping of the land cover changes and associated development of slope instabilities over 15 years, from a “pre-construction era” until now. We identify widespread deforestation and the land cover changes in upper chains of the fluvial systems to be the key drivers of the enhanced multiplication and intensification of the slope hazard processes. Completion of the active construction phase leads relatively quickly to a gradual natural stabilisation of the slope-located processes. However, the stream-located processes need several decades to regain a balance, because the increasing energy of small watercourses, due to growth of surface runoff coefficient, led to the transformation of longitudinal profiles of their channels. The obtained results provide a refined look at the anthropogenic influence on the slope instability occurrence and their short-time evolution in a mountain forest landscape. We also discuss the prospective course of events for this resort.
Perceived social support and depression among people living with HIV in China: roles of stigma and adherence self-efficacy
Authors: Wang Pengfei , Xiong Jianjing , Zheng Jinlei , Chai Chengliang , Wang Ying 
Published: December 2022

Abstract

Introduction People living with HIV (PLHIV) are a high-risk group for depression. In particular, the prevalence and burden of depression is higher and more severe among PLHIV in developing and less developed countries. There is evidence that perceived social support has a positive impact on reducing the occurrence of depression, and high stigma and low adherence self-efficacy are barriers to the effectiveness of social support for depressed PLHIV. However, how these risks affect the effect of social support on depression still needs further identification. Methods Between 2017 and 2018, a total of 1139 Chinese PLHIV (74.36% male, mean age = 43.91 years) from three provinces (Shanghai, Zhejiang and Henan) in China were enrolled in the study. Data were analyzed by multiple regression, mediation model and moderation model. Results 43.99% of PLHIV were with mild to severe depression. There was a significant negative association between perceived social support and depression (B = -0.049, P < 0.05). Stigma and adherence self-efficacy played a chain mediating role (B = -0.058, 95% CI [-0.078, -0.039]) and a moderating role in the effect of perceived social support on depression (stigma: B = -0.003, P < 0.05; adherence self-efficacy: B = 0.004, P < 0.05). Conclusion Stigma and adherence self-efficacy indirectly predicted depression, and perceived social support was more effective in reducing depression among PLHIV with high stigma or low adherence self-efficacy. Enhancing multiple social support resources for PLHIV may reduce their risk of depression. Moreover, the need for social support is greater for those with high stigma or low adherence self-efficacy.