bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric Properties of the Mental Health Continuum-Short Form (MHC-SF) in Iranian Adolescents
Authors: afrashteh majid yousefi 
Published: February 2022

Abstract
Background
Psychological tests are necessary to assess and assess the mental state of individuals. Mental health is one of the important psychological indicators and is increasingly considered as having various aspects of well-being. The Mental Health Continuum-Short Form (MHC-SF) is a 14-item instrument that assesses mental health, focusing on emotional, psychological, and social well-being. The present study examined the psychometric properties of the Persian version of the MHC-SF among adolescents, focusing on its factor structure, internal consistency, construct validity, and gender measurement invariance.
Methods
The population of this study was Iranian adolescents between 11 and 18 years old who were enrolled in the seventh to twelfth grades. A convenience sample of 822 Adolescents from four large cities in the Iran (Tehran, Zanjan, Hamedan and Ghazvin) participated in the present study. Questionnaires were completed online. Statistical analyses to evaluate the factor structure, internal consistency, construct validity, gender and age factorial invariance were performed in SPSS and LISREL.
Results
The results of confirmatory factor analysis supported the 3-factor structure of MHC-SF (emotional, psychological, and social well-being). Reliability was confirmed by Cronbach's alpha method and composite reliability (>.7). Measurement invariance were confirmed among girls and boys. Convergent and divergent validity were also evaluated and confirmed by correlating the test score with similar and different tests.
Conclusion
This study examined and confirmed the psychometric properties of GHQ in the Iranian adolescent community. This instrument can be used in psychological research and diagnostic evaluations.
Roost Culling as an Effective Management Strategy for Reducing Invasive Rose-Ringed Parakeet (Psittacula Krameri) Populations
Authors: Anderson C. Jane , Brennan Leonard , Bukoski William , Hess Steven , Hilton Clayton , Shiels Aaron , Siers Shane , Kluever Bryan , Klug Page 
Published: February 2022

Abstract
Rose-ringed parakeets (Psittacula krameri) are one of the most widespread invasive avian species worldwide. This species was introduced to the island of Kaua‘i, Hawai‘i, USA, in the 1960s. Depredation of crops by this species causes extensive economic losses. Large congregations in evening roosts damage trees and lead to excessive noise and droppings in public areas. We evaluated the efficacy of a roost culling program conducted by an independent contractor from March 2020 – March 2021. We estimated island-wide minimum abundance was 10,512 parakeets in January 2020 and 7,372 in April 2021. Over 30 nights of culling, approximately 6,030 parakeets were removed via air rifles with 4,415 (73%) confirmed via carcasses retrieval. An estimated average of 45 parakeets were removed per hour of shooter effort. The ratio of culled juveniles to adults was approximately 1.6:1.0. Age and sex structure of animals removed varied seasonally; the proportion of adult females removed in 2020 was 1.9× greater when culled outside of the estimated nesting season. Of the four roosts where culling occurred, the parakeets fully abandoned three and partially abandoned one site; of the three fully abandoned roosts, an estimated average of 29.6% of birds were culled prior to roost abandonment. This study was conducted during the COVID-19 pandemic, when tourist numbers and foot traffic were greatly reduced; it is unknown how public perception of roost culling in public areas may impact future efforts. Findings can be used to inform implementation of roost culling for management of nonnative rose-ringed parakeet populations.
Exosomal lncRNA TUG1 Derived From Human Urine-derived Stem Cells Attenuates Renal Ischemia/reperfusion Injury by Interacting With SRSF1 to Regulate ASCL4 Mediated Ferroptosis
Authors: Sun Zejia , Wu Jiyue , Bi Qing , Wang Wei 
Published: February 2022

Abstract
Background: Human urine-derived stem cells (USCs) derived exosomes protect against kidney ischemia/reperfusion injury (IRI), while the underlying mechanisms of this protective effect remain unclear. Methods: Human USCs and USCs derived exosomes (USC-Exo) were isolated and verified by morphology and specific biomarkers. The effects of USC-Exo on ferroptosis and kidney injury were detected in the IRI-induced acute kidney injury (AKI) model in C57BL/6 mice. The effects of USC-Exo on ferroptosis and lncRNA taurine upregulated gene 1 (TUG1) were detected in hypoxia/reoxygenation (H/R) treated human proximal tubular epithelial cells (HK-2). The interaction of SRSF1 and TUG1, ACSL4 were checked via RNA pull down/RIP and RNA stability assays. The effects of LncRNA TUG1 on SRSF1/ACSL4 mediated ferroptosis were verified in H/R treated HK-2 cells and the IRI-induced AKI mouse models.Results: USC-Exo treatment improved kidney injury and ameliorated ferroptosis in IRI-induced AKI mouse models. USC-Exo were rich in lncRNA TUG1, which regulated ferroptosis in HK-2 cells exposed to H/R. Mechanistically, lncRNA TUG1 regulates the stability of ACSL4 mRNA by interacting with RNA binding protein SRSF1. In addition, SRSF1 up-regulation or ACSL4 down-regulation partially reversed this protective effect of lncRNA TUG1 on ferroptosis in H/R treated HK-2 cells. Further, ACSL4 up-regulation partially reversed the protective effect on kidney injury and cell ferroptosis by lncRNA TUG1 in IRI-induced AKI mice. Conclusion: Collectively, lncRNA TUG1 carried by USC-Exo regulated ASCL4 mediated ferroptosis by interacting with SRSF1, then protected IRI-induced AKI. Potentially, USC-Exo rich in lncRNA TUG1 can serve as a promising therapeutic method for IRI-induced AKI.
Organic Residue Analysis Reveals the Function of Bronze Age Metal Daggers
Authors: Caricola Isabella , Charles Alasdair , Tirillò Jacopo , Charlton Fraser , Barton Huw , Breglia Francesco , Rossi Alberto , Deflorian Maria Chiara , Marinis Anna Maria , Harris Susanna , Pellegrini Alessio , Scacchetti Federico , Boccuccia Paolo , Miari Monica , Dolfini Andrea 
Published: February 2022

Abstract
The article discusses results of organic residue analysis performed on ten copper-alloy daggers from Bronze Age Pragatto, Italy, c.1550-1250 BCE. Metal daggers are widespread in Chalcolithic and Bronze Age Europe, yet their social and practical roles are still hotly debated. Are they symbolic or functional? Are they tools or weapons? How were they used? For what tasks and on what materials? The research addresses these questions through a novel application of biochemical staining and SEM-EDX analysis. The method has proved successful in extracting and identifying animal residues located on cutting edges including bone, muscle, and tendons. These are interpreted as evidence of prehistoric carcass butchering and carving. Further residues were observed on blade faces and hafting plates or tangs; these are interpreted as remnants of bone handles and sheaths, the latter made of either wood fibers or processed hide and fur. The readings proposed in the article are validated by original experiments with replica daggers, as detailed in the Supplementary Materials. The analysis and experiments shed new light on Bronze Age metal daggers, showing that they were fully functional tools (and perhaps tool-weapons) primarily utilized for the processing of animal carcasses. This original research result contributes significant knowledge towards interpreting an under-studied, yet socially salient, prehistoric metal artifact.
A Systematic Review On Correlates of Risk of TB Disease In Children And Adults
Authors: Siddhi P , Raveendranath R , Chinnaswamy A , Pulgari P , Song R , Welch Steven 
Published: February 2022

Abstract
Background: Tuberculosis (TB) remains one of the leading causes of death in the world. Targeted treatment to prevent progression from TB exposure and infection to disease is a key element of WHO End-TB strategy. A systematic review to identify and develop correlates of risk (COR) of TB disease is timely.Method: EMBASE, MEDLINE, PUBMED were searched using relevant keywords and MeSH terms published between 2000-2020 on COR of TB disease in children and adults. Preferred Reporting Items for Systematic reviews and Meta-analysis (PRISMA) framework was used for structuring and reporting of outcomes. Risk of bias was assessed using Quality Assessment of Diagnostic Accuracy Studies tool-2 (QUADAS-2).Results: 4105 studies were identified. Following eligibility screening, 27 studies were quality assessed. Risk of bias was high in all studies. Broad variations in COR type, study population, methodology and result reporting were observed. Tuberculin skin test (TST) and interferon gamma release essays (IGRA) are poor COR. Transcriptomic signatures although promising require validation studies to assess wider applicability. Performance consistency of other CORs- cell marker, cytokines and metabolites are much needed.Conclusion: This review identifies the need for a standardized approach to identify a universally applicable COR signature to achieve the WHO END-TB targets.
Psychometric Properties of the Farsi Version of the Gaming Disorder Scale for Adolescents
Authors: MazaheriZadeh Ali , TaheriFar Zahra , Farahani Hojjatollah 
Published: February 2022

Abstract
Background

Gaming disorder was added to the 11th international classification of disorders by the World Health Organization in early 2019. Adolescents are the most vulnerable group in this area, thus a screening tool for this age range is essential. This study aims to examine psychometric properties of the Gaming Disorder Scale for Adolescents (GADIS-A) in Iranian male sample.
Methods

260 students -7th to 12th grade- of Isfahan city in the academic year 2020-21 were selected using convenience sampling. The participants responded to the Farsi version of the GADIS-A and problematic online game questionnaire (POGQ). Thirty participants answered the scale again to assess validity of the retest. Pearson’s correlation analysis, Cronbach's alpha and confirmatory factor analysis were used in this research. The data were analyzed by SPSS version 24 and LISREL version 8.8.
Results

Confirmatory factor analysis revealed that the two-factor model, which included cognitive-behavioral symptoms and negative consequences, had good fitness indices. The GADIS-A convergent validity is confirmed by the scale's significant correlation with the POGQ. Cronbach's alpha coefficient was used to determine the scale's validity, which was 0.85 for the full scale and 0.70 and 0.75 for two factors. The validity of the retest after two weeks also showed a correlation of 0.88.
Conclusion

The Farsi version of the Gaming Disorder Scale for adolescents has a two-factor structure and is valid for use in Iran.
Epidemiological Assessment of Sars-Cov-2 Reinfection
Authors: AlMadhi Marwa , Alsayyad Adel Salman , Conroy Ronan , Atkin Stephen , Awadhi Abdulla Al , Al-Tawfiq Jaffar A. , AlQahtani Manaf 
Published: February 2022

Abstract

Introduction. Vaccination against SARS-CoV-2 infection has been shown to reduce the severity of infection; however, the overall reinfection rate in those unvaccinated, partially vaccinated and fully vaccinated remains unclear. Therefore, this study was undertaken to elucidate the rates and associated factors for such occurrences.Methods. This was a retrospective epidemiological report analysing 1362 COVID-19 reinfection cases in the Kingdom of Bahrain between April 2020 and July 2021. The differences in disease severity and characteristics of reinfection between various levels of vaccination statuses were determined among fully vaccinated, interrupted vaccination (positive test less than 14 days after receiving the second dose of vaccine), one dose of vaccination, post-reinfection vaccination and unvaccinated. Data were collected from the National COVID-19 Contact Tracing Team Database of individuals who tested positive for SARS-CoV-2.Results. During the study, reinfection cases increased from zero cases per month in April – June 2020 to a sharp peak of 579 reinfection cases in May 2021 followed by a rapid decline. Males constituted a significantly larger proportion of reinfections (n=821, 60.3%) than females (39.7%) (p<0.0001). Reinfection episodes were highest amongst the 30-39 years of age (n=405, 29.7%). The rate of reinfection increased with time from the initial infection with the lowest reinfection rate occurring at 3-6 months after the first infection (n=281, 20.6%) and the highest episodes occurring ≥9 months after initial infection (n=632, 46.4%). Comparison of the symptomatology between initial infection and reinfection episode for each individual showed that most individuals were asymptomatic during both episodes (n=486, 35.7%), while 265 (19.5%) individuals were symptomatic during both episodes. Reinfection disease severity was mild and differed across the cohort (X2 test p=0.003) with vaccinated patients less likely to have symptomatic reinfection (OR 0·71, p=0·004). Only 89 (6.6%) reinfection cases required hospitalization and there were no deaths (Poisson exact, 97.5% Cl 2.7 per 1000).Conclusion. Vaccine induced immunity and prior infection with or without vaccination were effective in reducing disease severity of reinfection episodes.
Prospective Intraoperative and Histologic Evaluation of Cavernous Sinus Medial Wall Invasion by Pituitary Adenomas: Implications for Acromegaly Outcomes
Authors: Mohyeldin Ahmed , Katznelson Laurence , Hoffman Andrew , Asmaro Karam , Ahmadian Saman , Eltobgy Mostafa , Nayak Jayakar , Patel Zara , Hwang Peter , Fernandez-Miranda Juan Carlos 
Published: February 2022

Abstract
Recurrence and biochemical remission rates vary widely among different histological subtypes of pituitary adenoma. In this prospective study, we evaluated 107 consecutive primary pituitary adenomas operated on by a single neurosurgeon including 28 corticotroph, 27 gonadotroph, 24 somatotroph, 17 lactotroph, 5 null-cell and 6 plurihormonal. In each case, we performed direct endoscopic intraoperative inspection of the medial wall of the cavernous sinus, which was surgically removed when invasion was visualized. This was performed irrespective of tumor functional status. Medial wall resection was performed in 47% of pituitary adenomas, and 39/50 walls confirmed pathologic evidence of invasion, rendering a positive predictive value of intraoperative evaluation of medial wall invasion of 78%. We show for the first-time dramatic disparities in the frequency of medial wall invasion among pathological subtypes. Somatotroph tumors invaded the medial wall much more often than other adenoma subtypes, 81% intraoperatively and 69% histologically, followed by plurihormonal tumors (40%) and gonadotroph cell tumors (33%), both with intraoperative positive predictive value of 100%. The least likely to invade were corticotroph adenomas, at a rate of 32% intraoperatively and 21% histologically, and null-cell adenomas at 0%. Removal of the cavernous sinus medial wall was not associated with permanent cranial nerve morbidity nor carotid artery injury, although 4 patients (all Knosp 3-4) experienced transient diplopia. Medial wall resection in acromegaly resulted in the highest potential for biochemical remission ever reported, with an average postoperative day 1 GH levels of 0.96 ug/L and surgical remission rates of 92% based on normalization of IGF-1 levels after surgery (mean = 15.56 months; range 3-12 months). Our findings suggest that tumor invasion of the medial wall of the cavernous sinus may explain the relatively low biochemical remission rates currently seen for acromegaly and illustrate the relevance of advanced intradural surgical approaches for successful and durable outcomes in endonasal pituitary surgery for functional adenomas.
The Effects of Green Credit Policy On The Formation of Zombie Firms: Evidence From Chinese Listed Firms
Authors: Chen Rui 
Published: February 2022

Abstract
This paper examines the effects of the green credit policy on forming three types of "zombie firms," namely, credit-subsidized zombie firms, poorly managed zombie firms, and comprehensive zombie firms, considering the quasi-natural experiment of the implementation of the "Green Credit Guidelines" in 2004. In this paper, I implement a difference-in-differences method and use the data of all Chinese A-share non-financial listed companies from 2008 to 2017. The results show that the green credit policy attempts to inhibit the formation of credit-subsidized zombie firms by reducing bank loan subsidies and evergreen lending. However, the green credit policy promotes poorly managed zombie firms by strengthening firms' financial constraints and reducing the working capital and investment efficiency. The green credit policy has not shown a significant impact on comprehensive zombie firms. Moreover, the green credit policy has shown a more significant impact on state-owned firms, firms in industries that heavily rely on external financing and are highly competitive, and firms involved in high financial marketization areas.
Influence of size and shape of the auricular surfaces on subchondral bone density distribution in the sacroiliac joint
Authors: Poilliot Amélie , Hammer Niels , Toranelli Mireille , Doyle Terence , Gay Max Hans-Peter , Müller-Gerbl Magdalena 
Published: February 2022

Abstract

The sacroiliac auricular surface is morphologically variable. The impact of morphology variations on subchondral mineralization distribution has not been investigated. Sixty-nine subject datasets were subjected to CT-osteoabsorptiometry for chronic loading visualization. Auricular surface morphologies were sorted into three types based on posterior angle size: >160°, 130-160° and <130°. Mineralization was qualitatively classified into four patterns: two marginal (M1, M2) and two non-marginal patterns (N1, N2), and each surface was assessed. The auricular surfaces averaged 15.4±3.6 cm2, with higher values in males. Sacral and iliac areas were significantly different between sexes. Type 2 was the most common (75%) and type 3 the least common morphology (9%). M1 was the most common pattern (62% of surfaces) by sex (males 60%, females 64%) with the anterior border as the maxima region in all three morphologies. Sacra have a majority of surfaces with patterns from the marginal group (98%). Ilia have mineralization concentrated at the anterior border (patterns M1+N2=83%). Load distribution differences related to morphological diversity seems to have little effect on stress-related bone adaptation visualized with CT-osteoabsorptiometry. Higher iliac side mineralization was observed in larger joints potentially related to cartilage distribution. Chronic loading adaptation might account for age-related morpho-mechanical size alterations in males.
The effect of tetrastarch on the endothelial glycocalyx layer in early hemorrhagic shock using fluorescence intravital microscopy: a mouse model
Authors: Uzawa Kohji , Ando Tadao , Yoshikawa Takahiro , Shingo Mitsuda , Yorozu Tomoko , Ushiyama Akira 
Published: February 2022

Abstract
Background: This study aimed to clarify the effects of the optimal timing of infusion therapy during massive hemorrhage by measuring the glycocalyx (GCX) damage and its effect on vascular endothelial cell dysfunction.Methods: In this randomized control animal study, we withdrew 1.5 mL of blood and administered 1.5 mL of infusion resuscitation. The mice were divided into the following six groups according to the type of infusion and administration timing: group NS-NS (Normal Saline (NS)→NS), group NS-Hydroxyethyl starch (HES) (NS→ Hydroxyethyl starch 130/0.4/9 (HES130)), group HES-NS (HES130→NS), group NS-Albumin (ALB) (NS→albumin), group ALB-NS (albumin→NS), and group C (control, no withdrawal or infusion). We investigated the vascular endothelial dysfunction based on the GCX impairment, measured indirectly through the interstitial fluorescence intensity and syndecan-1 concentration. Results: The GCX index (GCXI) of a 40 μm artery was significantly larger in group C than in the other groups (P<0.01). Similarly, the GCXI for a 60 μm artery was significantly larger compared with the NS-NS (P≤0.05), NS-HES (P≤0.01), and NS-ALB groups (P≤0.05). The plasma syndecan-1 concentration, at 7.70±5.71 ng/mL, was significantly lower in group C than in group NS-NS (P≤0.01). The tetramethylrhodamine-labeled dextran (TMR-DEX40) fluorescence intensity in the ALB-NS and HES-NS groups, as well as the fluorescein isothiocyanate-labeled hydroxyethyl starch (FITC-HES130) fluorescence intensity in the NS-HES and HES-NS groups, were not significantly different from those of group C at any time point. FITC-HES130 was localized on the inner wall of the vessels in groups without HES130 infusion but uniformly distributed in groups treated with HES130. Conclusions: In an acute massive hemorrhage mouse model, initial fluid resuscitation therapy with saline administration impaired GCX and increased the vascular permeability. Prior administration of HES130 prevented the progression of GCX damage. Early colloid resuscitation may improve endothelial cell function.
Meta-QTLs for multiple disease resistance involving three rusts in common wheat (Triticum aestivum L.)
Authors: Pal Neeraj , Jan Irfat , Saini Dinesh Kumar , Kumar Kuldeep , Kumar Anuj , Sharma Pradeep Kumar , Kumar Sundip , Balyan Harinder Singh , Gupta Pushpendra Kumar 
Published: February 2022

Abstract
Rust diseases in wheat are a major threat to global food security, therefore, the development of multiple disease-resistant cultivars (resistant to all three rusts) is a major goal in all wheat breeding programs worldwide. In the present study, meta-QTLs and candidate genes for multiple disease resistance (MDR) involving all the three rusts were identified using 152 individual QTL mapping studies for resistance to leaf rust (LR), stem rust (SR), and yellow rust (YR). From these 152 studies, a total of 1,146 QTLs for resistance to the three rusts were retrieved, which included 368 QTLs for LR, 291 QTLs for SR, and 487 QTLs for YR. Of these 1,146 QTLs, only 718 QTLs could be projected onto the consensus map saturated with 234,619 markers. Meta-analysis of the projected QTLs resulted in the identification of 86 MQTLs, which included 71 MDR-MQTLs. Ten of these MDR-MQTLs were referred to as the ‘Breeders’ MQTLs’. Seventy-eight of the 86 MQTLs could also be anchored to the physical map of the wheat genome and 54 MQTLs were validated by marker-trait associations identified during earlier genome-wide association studies. Twenty MQTLs (including 17 MDR-MQTLs) identified in the present study were co-localized with 42 known R genes. In silico expression analysis allowed identification of several differentially expressed candidate genes encoding proteins carrying different domains including the following: NBS-LRR, WRKY domains, F-box domains, sugar transporters, transferases, etc. The introgression of these MDR loci into high-yielding cultivars should prove useful for developing high yielding cultivars with resistance to all three rusts.