bluuebunny/crossref_metadata_2025_split huggingface dataset:
Berberine bridge enzyme-like oxidase-catalysed double bond isomerization acts as the pathway switch in cytochalasin synthesis
Authors: Zhang Jin-Mei , Liu Xuan , Wei Qian , Ma Chuanteng , Li Dehai , Zou Yi 
Published: January 2022

AbstractCytochalasans (CYTs), as well as their polycyclic (pcCYTs) and polymerized (meCYTs) derivatives, constitute one of the largest families of fungal polyketide-nonribosomal peptide (PK-NRP) hybrid natural products. However, the mechanism of chemical conversion from mono-CYTs (moCYTs) to both pcCYTs and meCYTs remains unknown. Here, we show the first successful example of the reconstitution of the CYT core backbone as well as the whole pathway in a heterologous host. Importantly, we also describe the berberine bridge enzyme (BBE)-like oxidase AspoA, which uses Glu538 as a general acid biocatalyst to catalyse an unusual protonation-driven double bond isomerization reaction and acts as a switch to alter the native (for moCYTs) and nonenzymatic (for pcCYTs and meCYTs) pathways to synthesize aspochalasin family compounds. Our results present an unprecedented function of BBE-like enzymes and highly suggest that the isolated pcCYTs and meCYTs are most likely artificially derived products.
The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage
Authors: Girard Romain , Tremblay Sarah , Noll Christophe , St-Jean Stéphanie , Jones Christine , Gélinas Yves , Maloum-Rami Faïza , Perreault Nathalie , Laplante Mathieu , Carpentier André C. , Boudreau François 
Published: January 2022

AbstractThe transcription factor hepatocyte nuclear factor 4 A (HNF4A) controls the metabolic features of several endodermal epithelia. Both HNF4A and HNF4G are redundant in the intestine and it remains unclear whether HNF4A alone controls intestinal lipid metabolism. Here we show that intestinal HNF4A is not required for intestinal lipid metabolism per se, but unexpectedly influences whole-body energy expenditure in diet-induced obesity (DIO). Deletion of intestinal HNF4A caused mice to become DIO-resistant with a preference for fat as an energy substrate and energetic changes in association with white adipose tissue (WAT) beiging. Intestinal HNF4A is crucial for the fat-induced release of glucose-dependent insulinotropic polypeptide (GIP), while the reintroduction of a stabilized GIP analog rescues the DIO resistance phenotype of the mutant mice. Our study provides evidence that intestinal HNF4A plays a non-redundant role in whole-body lipid homeostasis and points to a non-cell-autonomous regulatory circuit for body-fat management.
Signatures of selection in recently domesticated macadamia
Authors: Lin Jishan , Zhang Wenping , Zhang Xingtan , Ma Xiaokai , Zhang Shengcheng , Chen Shuai , Wang Yibin , Jia Haifeng , Liao Zhenyang , Lin Jing , Zhu Mengting , Xu Xiuming , Cai Mingxing , Zeng Hui , Wan Jifeng , Yang Weihai , Matsumoto Tracie , Hardner Craig , Nock Catherine J. , Ming Ray 
Published: January 2022

AbstractMacadamia is a high value nut crop that is recently domesticated, ideal for testing the effect of artificial selection. Here, we sequence the genome of Hawaiian cultivar ‘Kau’ and assemble into 794 Mb in 14 pseudo-chromosomes with 37,728 genes. Genome analysis reveals a whole-genome duplication event, occurred 46.8 million years ago. Gene expansions occurred in gene families involves in fatty acid biosynthesis. Gene duplication of MADS-Box transcription factors in proanthocyanidin biosynthesis are relevant for seed coat development. Genome re-sequencing of 112 accessions reveals the origin of Hawaiian cultivars from Mount Bauple in southeast Queensland in Australia. Selective sweeps are detected in macadamia cultivars, including genes involved in fatty acid biosynthesis, seed coat development, and heat stress response. Such strong effects of artificial selection in few generations reveals the genomic basis for ‘one-step operation’ for clonal crop domestication. The knowledge gained could accelerate domestication of new crops from wild species.
Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson’s disease
Authors: Cury Rubens Gisbert , Pavese Nicola , Aziz Tipu Z. , Krauss Joachim K. , Moro Elena ,   the Neuromodulation of Gait Study Group from Movement Disorders Society
Published: January 2022

AbstractGait issues in Parkinson’s disease (PD) are common and can be highly disabling. Although levodopa and deep brain stimulation (DBS) of the subthalamic nucleus and the globus pallidus internus have been established therapies for addressing the motor symptoms of PD, their effects on gait are less predictable and not well sustained with disease progression. Given the high prevalence of gait impairment in PD and the limitations in currently approved therapies, there has been considerable interest in alternative neuromodulation targets and techniques. These have included DBS of pedunculopontine nucleus and substantia nigra pars reticulata, spinal cord stimulation, non-invasive modulation of cortical regions and, more recently, vagus nerve stimulation. However, successes and failures have also emerged with these approaches. Current gaps and controversies are related to patient selection, optimal electrode placement within the target, placebo effects and the optimal programming parameters. Additionally, recent advances in pathophysiology of oscillation dynamics have driven new models of closed-loop DBS systems that may or may not be applicable to gait issues. Our aim is to describe approaches, especially neuromodulation procedures, and emerging challenges to address PD gait issues beyond subthalamic nucleus and the globus pallidus internus stimulation.
Distanced self-talk increases rational self-interest
Authors: Gainsburg Izzy , Sowden Walter J. , Drake Brittany , Herold Warren , Kross Ethan 
Published: January 2022

AbstractDoes stepping back to evaluate a situation from a distanced perspective lead us to be selfish or fair? This question has been of philosophical interest for centuries, and, more recently, the focus of extensive empirical inquiry. Yet, extant research reveals a puzzle: some studies suggest that adopting a distanced perspective will produce more rationally self-interested behavior, whereas others suggest that it will produce more impartial behavior. Here we adjudicate between these perspectives by testing the effects of adopting a third-person perspective on decision making in a task that pits rational self-interest against impartiality: the dictator game. Aggregating across three experiments (N = 774), participants who used third-person (i.e., distanced) vs. first-person (i.e., immersed) self-talk during the dictator game kept more money for themselves. We discuss these results in light of prior research showing that psychological distance can promote cooperation and fairmindedness and how the effect of psychological distance on moral decision-making may be sensitive to social context.
Maximum 11C-methionine PET uptake as a prognostic imaging biomarker for newly diagnosed and untreated astrocytic glioma
Authors: Nakajo Kosuke , Uda Takehiro , Kawashima Toshiyuki , Terakawa Yuzo , Ishibashi Kenichi , Tsuyuguchi Naohiro , Tanoue Yuta , Nagahama Atsufumi , Uda Hiroshi , Koh Saya , Sasaki Tsuyoshi , Ohata Kenji , Kanemura Yonehiro , Goto Takeo 
Published: January 2022

AbstractThis study aimed whether the uptake of amino tracer positron emission tomography (PET) can be used as an additional imaging biomarker to estimate the prognosis of glioma. Participants comprised 56 adult patients with newly diagnosed and untreated World Health Organization (WHO) grade II–IV astrocytic glioma who underwent surgical excision and were evaluated by 11C-methionine PET prior to the surgical excision at Osaka City University Hospital from July 2011 to March 2018. Clinical and imaging studies were retrospectively reviewed based on medical records at our institution. Preoperative Karnofsky Performance Status (KPS) only influenced progression-free survival (hazard ratio [HR] 0.20; 95% confidence interval [CI] 0.10–0.41, p < 0.0001), whereas histology (anaplastic astrocytoma: HR 5.30, 95% CI 1.23–22.8, p = 0.025; glioblastoma: HR 11.52, 95% CI 2.27–58.47, p = 0.0032), preoperative KPS ≥ 80 (HR 0.23, 95% CI 0.09–0.62, p = 0.004), maximum lesion-to-contralateral normal brain tissue (LN max) ≥ 4.03 (HR 0.24, 95% CI 0.08–0.71, p = 0.01), and isocitrate dehydrogenase (IDH) status (HR 14.06, 95% CI 1.81–109.2, p = 0.011) were factors influencing overall survival (OS) in multivariate Cox regression. OS was shorter in patients with LN max ≥ 4.03 (29.3 months) than in patients with LN max < 4.03 (not reached; p = 0.03). OS differed significantly between patients with IDH mutant/LN max < 4.03 and patients with IDH mutant/LN max ≥ 4.03. LN max using 11C-methionine PET may be used in prognostic markers for newly identified and untreated WHO grade II–IV astrocytic glioma.
Discontinuation of Azathioprine could be considered in pediatric patients with Crohn’s disease who have sustained clinical and deep remission
Authors: Jeong Tae Jong , Kim Eun Sil , Kwon Yiyoung , Kim Seonwoo , Seo Sang Won , Choe Yon Ho , Kim Mi Jin 
Published: January 2022

AbstractFew studies have demonstrated treatment strategies about the duration and cessation of medications in patients with Crohn’s disease (CD). We investigated factors affecting clinical relapse after infliximab (IFX) or azathioprine (AZA) withdrawal in pediatric patients with CD on combination therapy. Pediatric patients with moderate-to-severe CD receiving combination therapy were analyzed retrospectively and factors associated with clinical relapse were investigated. Discontinuation of IFX or AZA was performed in patients who sustained clinical remission (CR) for at least two years and achieved deep remission. A total of 75 patients were included. Forty-four patients (58.7%) continued with combination therapy and 31 patients (41.3%) discontinued AZA or IFX (AZA withdrawal 10, IFX withdrawal 15, both withdrawal 6). Cox proportional-hazards regression and statistical internal validation identified three factors associated with clinical relapse: IFX cessation (hazard ratio; HR 2.982, P = 0.0081), IFX TLs during maintenance therapy (HR 0.581, P = 0.003), 6-thioguanine nucleotide (6-TGN) level (HR 0.978, P < 0.001). However, AZA cessation was not associated with clinical relapse (P = 0.9021). Even when applied in pediatric patients who met stringent criteria, IFX cessation increased the relapse risk. However, withdrawal of AZA could be contemplated in pediatric patients with CD who have sustained CR for at least 2 years and achieved deep remission.
Petrophysical core-based zonation of OW oilfield in the Bredasdorp Basin South Africa
Authors: Opuwari Mimonitu , Afolayan Blessing , Mohammed Saeed , Amaechi Paschal Ogechukwu , Bareja Youmssi , Chatterjee Tapas 
Published: January 2022

AbstractThis study aims to generate rock units based on core permeability and porosity of OW oilfield in the Bredasdorp Basin offshore South Africa. In this study, we identified and classified lithofacies based on sedimentology reports in conjunction with well logs. Lucia's petrophysical classification method is used to classify rocks into three classes. Results revealed three lithofacies as A (sandstone, coarse to medium-grained), B (fine to medium-grained sandstone), and C (carbonaceous claystone, finely laminated with siltstone). Lithofacies A is the best reservoir quality and corresponds to class 1, while lithofacies B and C correspond to class 2 and 3, which are good and poor reservoir quality rock, respectively. An integrated reservoir zonation for the rocks is based on four different zonation methods (Flow Zone indicator (FZI), Winland r35, Hydraulic conductivity (HC), and Stratigraphy modified Lorenz plot (SMLP)). Four flow zones Reservoir rock types (RRTs) were identified as RRT1, RRT3, RRT4, and RRT5, respectively. The RRT5 is the best reservoir quality composed of a megaporous rock unit, with an average FZI value between 5 and 10 µm, and HC from 40 to 120 mD/v3, ranked as very good. The most prolific flow units (RRT5 and RRT4 zones) form more than 75% of each well's flow capacities are supplied by two flow units (FU1 and FU3). The RRT1 is the most reduced rock quality composed of impervious and nanoporous rock. Quartz is the dominant framework grain, and siderite is the dominant cement that affects flow zones. This study has demonstrated a robust approach to delineate flow units in the OW oilfield. We have developed a useful regional petrophysical reservoir rock flow zonation model for clastic reservoir sediments. This study has produced, for the first time, insights into the petrophysical properties of the OW oilfield from the Bredasdorp Basin South Africa, based on integration of core and mineralogy data. A novel sandstone reservoir zonation classification criteria developed from this study can be applied to other datasets of sandstone reservoirs with confidence.
EEG signatures change during unilateral Yogi nasal breathing
Authors: Niazi Imran Khan , Navid Muhammad Samran , Bartley Jim , Shepherd Daniel , Pedersen Mangor , Burns Georgina , Taylor Denise , White David E. 
Published: January 2022

AbstractAirflow through the left-and-right nostrils is said to be entrained by an endogenous nasal cycle paced by both poles of the hypothalamus. Yogic practices suggest, and scientific evidence demonstrates, that right-nostril breathing is involved with relatively higher sympathetic activity (arousal states), while left-nostril breathing is associated with a relatively more parasympathetic activity (stress alleviating state). The objective of this study was to further explore this laterality by controlling nasal airflow and observing patterns of cortical activity through encephalographic (EEG) recordings. Thirty subjects participated in this crossover study. The experimental session consisted of a resting phase (baseline), then a period of unilateral nostril breathing (UNB) using the dominant nasal airway, followed by UNB using the non-dominant nasal airway. A 64-channel EEG was recorded throughout the whole session. The effects of nostril-dominance, and nostril-lateralization were assessed using the power spectral density of the neural activity. The differences in power-spectra and source localization were calculated between EEG recorded during UNB and baseline for delta, theta, alpha, beta and gamma bands. Cluster-based permutation tests showed that compared to baseline, EEG spectral power was significantly (1) decreased in all frequency bands for non-dominant nostril UNB, (2) decreased in alpha, beta and gamma bands for dominant nostril UNB, (3) decreased in all bands for left nostril UNB, and (4) decreased in all bands except delta for right nostril UNB. The beta band showed the most widely distributed changes across the scalp. our source localisation results show that breathing with the dominant nostril breathing increases EEG power in the left inferior frontal (alpha band) and left parietal lobule (beta band), whereas non-dominant nostril breathing is related to more diffuse and bilateral effects in posterior areas of the brain.These preliminary findings may stimulate further research in the area, with potential applications to tailored treatment of brain disorders associated with disruption of sympathetic and parasympathetic activity.
Surgeons have hesitated early cholecystectomy because of cardiovascular comorbidities during adoption of guidelines
Authors: Onishi Ichiro , Kayahara Masato , Yamaguchi Takahisa , Yamaguchi Yukari , Morita Akihiko , Sato Nariatsu , Kurosaka Yoshiyuki , Takegawa Shigeru 
Published: January 2022

AbstractThe introduction of the guidelines has resulted in an increase of laparoscopic surgeries performed, but the rate of early surgery was still low. Here, the initial effect of the introduction of the guideline was confirmed in single center, and factors disturbing early cholecystectomy were analyzed. This study included 141 patients who were treated for acute cholecystitis from January 2010 to October 2014 at Kanazawa Medical Center. Each patient was assigned into a group according to when they received treatment. Patients in Group A were treated before the Tokyo Guidelines were introduced (n = 48 cases), those in Group B were treated after the introduction of the guidelines (93 cases). After the introduction of the guidelines, early laparoscopic cholecystectomy was significantly increased (P < 0.001), however, the rate of early operations was still 38.7% only. There are many cases with cardiovascular disease in delayed group, the prevalence had reached 50% as compared with early group of 24% (P < 0.01). Approximately 25% of patients continued antiplatelet or anticoagulant therapy. In the early days of guidelines introduction, the factor which most disturbed early surgery was the coexistence of cardiovascular disease. These contents could be described in the next revision of the guidelines.
Chemical composition, quality attributes and antioxidant activity of stirred-type yogurt enriched with Melastoma dodecandrum Lour fruit powder
Authors: Rashwan Ahmed K. , Karim Naymul , Xu Yang , Cui Haoxin , Fang Jie , Cheng Kejun , Mo Jianling , Chen Wei 
Published: January 2022

Incorporation of Melastoma dodecandrum Lour fruit powder as a promising functional ingredient for stirred-type yogurt (STY) improved physicochemical properties, polyphenol contents, antioxidant activity, microstructure, and texture of STY.
A fractional time‐step simulation method suitable for the associated discrete circuit model of power electronic system
Authors: Wu Pan , Xu Jin , Wang Keyou , Li Zirun , Li Guojie 
Published: January 2022

AbstractThe associated discrete circuit (ADC) model for switches is widely used in electromagnetic transient simulation of power electronic system. When using ADC model, the problem of virtual power loss caused by L/C switching cannot be ignored and small time‐step (≤2 μs) is usually required to guarantee accuracy, both of which will limit the application of ADC model. To cope with this, a fractional time‐step simulation method (FTSSM) suitable for the ADC model of power electronic system is proposed. The method is derived from the compact form of electro‐magnetic transient program (EMTP) algorithm, and the simulation iteration is implemented by small‐step synthesis calculation with different fractional time‐steps, which are designed to locate the accurate switching actions. In this way, the simulation can be conducted under larger time‐step (to tens of μs) while the accuracy is still acceptable. Further analysis on time domain error and numerical stability of the FTSSM are discussed. Simulations of grid‐connected inverter system and permanent magnet synchronous motor (PMSM) driving system are done, using FTSSM and on PSCAD respectively for comparison. The results verify the accuracy of proposed FTSSM, and indicate that the FTSSM is helpful to accelerate the offline simulation and improve the real‐time simulation performance.
A compressed sensing and CNN‐based method for fault diagnosis of photovoltaic inverters in edge computing scenarios
Authors: Wang Xinyi , Yang Bo , Wang Zhaojian , Liu Qi , Chen Cailian , Guan Xinping 
Published: January 2022

AbstractAccurate and real‐time diagnosis of the inverter is crucial for the reliability, safety and generation efficiency of the photovoltaic (PV) system. Recently, deep learning (DL) is widely used for accurate diagnosis, which automatically extracts useful features instead of relying on experts. For real‐time diagnosis, in an emerging edge computing paradigm, massive data generated by end‐device are processed in nearby edge nodes, which reduces energy consumption and latency. However, large amounts of data are required for model training in the cloud, which leads to tremendous burdens of transmission and computation. To tackle these issues, a data‐driven diagnosis method based on compressed sensing (CS) and convolutional neural network (CNN) is proposed for open‐circuit faults of PV inverters. Based on CS, raw signals are compressed in edge nodes with the optimal compression ratio determined by experiments. The proposed CS‐CNN is evaluated on an edge‐cloud semi‐physical experiment platform. Compared with common compression methods, the accuracy of CS is improved by more than 3%, and the time consumption is only one‐fifth. Compared with the CNN of the same structure, the transmission and computation time is largely reduced by an order of magnitude. The developed CS‐CNN compresses 85% of data with a test accuracy of 99.18%.
Comparative study of reformed neural network based short‐term wind power forecasting models
Authors: Xing Zuoxia , Qu Boyang , Liu Yang , Chen Zhe 
Published: January 2022

AbstractShort‐term prediction of wind power plays a vital role in wind power application. In order to improve the accuracy of wind power forecasting, this paper investigates neural network combined forecasting models to forecast the wind power, the data of a real wind farm, the Pacific Wind Farm, is used. In view of the difficulty of predicting the large fluctuations of wind power, the complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) algorithm is used to decompose the wind power time series which can reduce the complexity of the forecasting process, and then the intrinsic mode function (IMF) signal is predicted by the BP Neural Network, wavelet neural network (WNN) and long short‐term memory (LSTM) neural network respectively, and the final result is obtained through wavelet reconstruction. By comparing with a single model, the combined prediction model has better prediction accuracy and stability, among them, the NMAE predicted by CEEMDAN‐GA‐BP in January was 4.167%, and the NRMSE was 6.590%. Reformed neural network based short‐term wind power forecasting models proposed in here provides very useful information for operation and control of high renewable energy penetrated power systems.
Zeeman Doppler mapping revisited: Force-free fields, regularisation functions, and abundance maps
Authors: Stift M. J. , Leone F. 
Published: January 2022

Aims. For the observational modelling of horizontal abundance distributions and of magnetic geometries in chemically peculiar (CP) stars, Zeeman Doppler mapping (ZDM) has become the method of choice. Comparisons between abundance maps obtained for CP stars and predictions from numerical simulations of atomic diffusion have always proved unsatisfactory. This study is intended to explore the reasons for the discrepancies.
Methods. We cast a cold eye (evoking the epitaph on Nobel laureate W.B. Yeats’ gravestone: Cast a cold Eye / On Life, on Death. / Horseman, pass by) on essential assumptions underlying ZDM, in particular, the formulae governing the magnetic field geometry, but also the regularisation functionals.
Results. Recognising that the observed strong magnetic fields in most well-mapped stars require the field geometry to be force free, we show that the formulae used so far to describe the magnetic geometry do not meet this condition. It follows that the published magnetic maps and the abundance maps of these stars are all spurious.
Conclusions. To obtain observational constraints for the modelling of atomic diffusion, the use in ZDM of the correct formulae for force-free or potential magnetic fields is paramount. Extensive simulations are required to quantify the effects of chemical stratifications and of regularisation functions on the recovered magnetic and abundance maps.