bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Profile of Adult Organophosphorus Compound Poisoning in a Tertiary Care Hospital
Authors: Hoq Md Enamul , Islam AKM Shafiqul , Sharmin Rubaba , Akbar Mohammad Shafiqullah , Islam Mohammad Mushaidul , Roy Soumitra , Fayaz Md Abul 
Published: August 2022

Despite the apparent benefits of organophosphate compounds (OPCs) acute organophosphate (OP) pesticide poisoning is an increasing problem worldwide. In a country like Bangladesh, where agriculture is a major component of the economy, these compounds are readily available to the general public. There is paucity of evidence from Bangladesh showing the pattern of organophosphate poisoning (OPP) in healthcare facilities. The aim of this study is to see the clinical profile of organophosphorus compound poisoning in admitted patients of tertiary care hospital.
Methods: This observational cross-sectional study was carried out over all admitted patient with OPC poisoning in the department of Medicine, Cumilla Medical college, Cumilla from July 2019 to January 2020. A total of 100 cases were enrolled in the study. Patients having history of poisoning with OPC compound were stabilized by ABC care system and then assessed according to detailed history, physical examination and paradeniya organophosphorus poisoning (POP) scale.
Results: The mean age was found 25.0±8.0 years and male to female ratio was 1:1.2, were mostly married (78.0%) and most of them from poor family (86%). The commonest manner of poisoning was suicidal (90.0%) with oral ingestion. More than eighty (84.0%) percent patients came from rural area. Commonest symptoms were abdominal pain (88.0%), vomiting (63.0%), excessive sweating (58.0%), salivation (35.0%), breathlessness (34.0%) and lacrimation (27.0%). Total hospitalization period was more than one week and less than two weeks in majority of cases (73%) and mortality rate was 2.0%.
Conclusion: Due to increasing numbers of organophosphorus poisoning cases in younger age groups strict legislature on the availability of organophosphate compounds, preventive measures and appropriate health education should be introduced to decrease the incidence.
Central Medical College Journal Vol 5 No 2 Jul 2021 PP 76-83
Effect of Topical Insulin Versus Normal Saline Dressing in Healing of Diabetic Foot Ulcers
Authors: Uddin Md Abbas , Hasina Ayesha , Shill Sajal kumar 
Published: August 2022

Diabetic foot ulcer is a common cause of admission in the surgical wards and sometimes the first presentation of this debilitating disease. Numerous topical medication and gels are promoted for ulcer care and healing. Relatively few have proved to be more efficacious than normal saline dressing. This study aimed to compare the effect of topical insulin versus normal saline dressing in healing of diabetic foot ulcers at Rajshahi Medical College Hospital, Rajshahi.
Aims and objectives: To assess the effect of topical insulin versus normal saline dressing in healing of diabetic foot ulcers.
Methods: A total of 60 patients with diabetic foot ulcers were studied in different units of surgical ward of Rajshahi Medical College Hospital from July 2017 to June 2019. Patients were divided into two groups of 30 patients each that is group A (topical insulin) and group B (Normal saline). Ratio, mean, standard deviation, Pearson Chi-Square test were applied appropriately to this study.
Results: Among the 60 patients, majority of the patients were males in both the groups (73.33% in group A and 80.00% in group B) with male to female ratio of 2.7:1 in group A and 4:1 in group B. The mean age in group A was 50.00±7.33 years and in group B it was 53.00±7.80 years, where P=1.00. Among patients with group A significant reduction of mean ulcer area was observed (314.30±171.26 mm2 ) with higher mean percentage reduction (15.30±3.28 percent), whereas, in group B the mean percentage reduction was significantly less (6.35±2.03 percent) with less reduction of mean final ulcer area (110.5±56.23mm2), where P<0.001.
Conclusions: Topical insulin dressing provided better outcome in patients with diabetic foot ulcers by significant reduction in wound area when compared to normal saline dressing.
Central Medical College Journal Vol 5 No 2 Jul 2021 PP 94-101
Prevalence, Clinical Pattern and Presentations of Psoriasis in A Tertiary Care Hospital of Bangladesh
Authors: Kalam Md Abul , Islam Kismat Ara , Akber Elias Bin , Jahan Israt 
Published: August 2022

To find out different presentations of Psoriasis in Bangladesh.
Material and Methods: This is a cross sectional study of all dermatology patients with features of psoriasis who attended the dermatology outpatient clinic of the hospital between July 2016 and June 2017. Data was collected on a perform questionnaire. Age, gender and clinical presentations were recorded and analyzed using SPSS version 16.
Results: Psoriasis was found in 1.13% (60/5505) of the study population. There was a male preponderance with a male to female ratio of 1.34:1. The majority of patients seen were in the fourth decade of life. Stress, alcohol, and drugs were the most reported predisposing factors to psoriasis. All types of psoriasis were found, and plaque psoriasis was the most common.
Conclusion: Psoriasis is a one of the common skin diseases with wide range of clinical variation and predisposing factors. The current trend in the management of psoriasis is focused on treating the inflammatory process as well as managing the modifiable environmental triggers.
Central Medical College Journal Vol 5 No 2 Jul 2021 PP 102-105
A tagállamok fiskális hatásköreinek gyakorlása során hozott döntéseinek felülvizsgálata az EUB gyakorlatában
Authors: Szuchy Róbert , Korom Ágoston 
Published: August 2022

A tagállamok fiskális hatásköreik gyakorlása során adókat szednek be, illetve gazdasági szereplőknek támogatásokat nyújtanak. A tagállamok e területen nem élveznek korlátlan mozgásteret, gyakran előfordul, hogy egy gazdasági szereplőnek nyújtott támogatás vagy beszedett adó nem felel meg az uniós jog kritériumainak.Ilyen esetekben főszabályként, különösen a belső piaccal összeegyeztethetetlen támogatás esetén, az adókat, és a támogatásokat is vissza kell téríteni. E főszabály alól jelent kivételt, ha az adott döntés jogerőre emelkedett, ilyen esetben az uniós jog nem követeli meg a kérdéses döntések felülvizsgálatát.Azonban e kivétel nem minden esetben alkalmazható, valamint a belső piaccal összeegyeztethetetlen támogatásokra speciális szabályok vonatkoznak. E dolgozatban azt vizsgáljuk, hogy mely esetekben kell eltekinteni a tagállami jogerős döntésektől. Jelentős állami támogatások visszafizetése, vagy éveken át befizetett adók utólagos visszafizetése komoly befolyást gyakorolhat a gazdasági szereplők, valamint a tagállamok költségvetésére is.
PBC, an easy and efficient strategy for high-throughput protein C-terminome profiling
Authors: Zhai Linhui , Wang Le , Hu Hao , Liu Quan , Lee Sangkyu , Tan Minjia , Zhang Yinan 
Published: August 2022

High-throughput profiling of protein C-termini is still a challenging task. Proteomics provides a powerful technology for systematic and high-throughput study of protein C-termini. Various C-terminal peptide enrichment strategies based on chemical derivatization and chromatography separation have been reported. However, they are still costly and time-consuming, with low enrichment efficiency for C-terminal peptides. In this study, by taking advantage of the high reaction selectivity of 2-pyridinecarboxaldehyde (2-PCA) with an α-amino group on peptide N-terminus and high affinity between biotin and streptavidin, we developed a 2-PCA- and biotin labeling–based C-terminomic (PBC) strategy for a high-efficiency and high-throughput analysis of protein C-terminome. Triplicates of PBC experiments identified a total of 1,975 C-terminal peptides corresponding to 1,190 proteins from 293 T cell line, which is 180% higher than the highest reported number of C-terminal peptides identified from mammalian cells by chemical derivatization–based C-terminomics study. The enrichment efficiency (68%) is the highest among the C-terminomics methods currently reported. In addition, we not only uncovered 50 proteins with truncated C-termini which were significantly enriched in extracellular exosome, vesicle, and ribosome by a bioinformatic analysis but also systematically characterized the whole PTMs on C-terminal in 293 T cells, suggesting PBC as a powerful tool for protein C-terminal degradomics and PTMs investigation. In conclusion, the PBC strategy would benefit high-efficiency and high-throughput profiling of protein C-terminome.
Epidemiological characteristics of P. vivax asymptomatic infections in the Peruvian Amazon
Authors: Villasis Elizabeth , Garcia Castillo Stefano S. , Guzman Mitchel , Torres Julian , Gomez Joaquin , Garro Katherine , Cordova Ana Maria , Reategui Carolina , Abanto Caroline , Vinetz Joseph , Gamboa Dionicia , Torres Katherine 
Published: August 2022

IntroductionHerein, we tested the hypothesis that Asymptomatic P. vivax (Pv) infected individuals (Asym) feature different epidemiological, clinical and biochemical characteristics, as well as hematological parameters, potentially predictive of clinical immunity in comparison to symptomatic Pv infected individuals (Sym).MethodologyBetween 2018 - 2021, we conducted 11 population screenings (PS, Day 0 (D0)) in 13 different riverine communities around Iquitos city, in the Peruvian Amazon, to identify Pv Sym and Asym individuals. A group of these individuals agreed to participate in a nested case - control study to evaluate biochemical and hematological parameters. Pv Asym individuals did not present common malaria symptoms (fever, headache, and chills), had a positive/negative microscopy result, a positive qPCR result, reported no history of antimalarial treatment during the last month, and were followed-up weekly until Day 21 (D21). Control individuals, had a negative malaria microscopy and qPCR result, no history of antimalarial treatment or malaria infections during the last three years, and no history of comorbidities or chronic infections.ResultsFrom the 2159 individuals screened during PS, data revealed a low but heterogeneous Pv prevalence across the communities (11.4%), where most infections were Asym (66.7%) and submicroscopic (82.9%). A total of 29 Asym, 49 Sym, and 30 control individuals participated in the nested case - control study (n=78). Ten of the individuals that were initially Asym at D0, experienced malaria symptoms during follow up and therefore, were included in the Sym group. 29 individuals remained Asym throughout all follow-ups. High levels of eosinophils were found in Asym individuals in comparison to Sym and controls.ConclusionFor the first-time, key epidemiological, hematological, and biochemical features are reported from Pv Asym infections from the Peruvian Amazon. These results should be considered for the design and reshaping of malaria control measures as the country moves toward malaria elimination.
Retinal vascular measures from diabetes retinal screening photographs and risk of incident dementia in type 2 diabetes: A GoDARTS study
Authors: Doney Alexander S. F. , Nar Aditya , Huang Yu , Trucco Emanuele , MacGillivray Tom , Connelly Peter , Leese Graham P. , McKay Gareth J. ,   on behalf of the INSPIRED consortium
Published: August 2022

ObjectivePatients with diabetes have an increased risk of dementia. Improved prediction of dementia is an important goal in developing future prevention strategies. Diabetic retinopathy screening (DRS) photographs may be a convenient source of imaging biomarkers of brain health. We therefore investigated the association of retinal vascular measures (RVMs) from DRS photographs in patients with type 2 diabetes with dementia risk.Research Design and MethodsRVMs were obtained from 6,111 patients in the GoDARTS bioresource (635 incident cases) using VAMPIRE software. Their association, independent of Apo E4 genotype and clinical parameters, was determined for incident all cause dementia (ACD) and separately Alzheimer's disease (AD) and vascular dementia (VD). We used Cox’s proportional hazards with competing risk of death without dementia. The potential value of RVMs to increase the accuracy of risk prediction was evaluated.ResultsIncreased retinal arteriolar fractal dimension associated with increased risk of ACD (csHR 1.17; 1.08–1.26) and AD (HR 1.33; 1.16–1.52), whereas increased venular fractal dimension (FDV) was associated with reduced risk of AD (csHR 0.85; 0.74–0.96). Conversely, FDV was associated with increased risk of VD (csHR 1.22; 1.07–1.40). Wider arteriolar calibre was associated with a reduced risk of ACD (csHR 0.9; 0.83–0.98) and wider venular calibre was associated with a reduced risk of AD (csHR 0.87; 0.78–0.97). Accounting for competing risk did not substantially alter these findings. RVMs significantly increased the accuracy of prediction.ConclusionsConventional DRS photographs could enhance stratifying patients with diabetes at increased risk of dementia facilitating the development of future prevention strategies.
Development and validation of a nomogram for risk prediction of nephrolithiasis recurrence in patients with primary hyperparathyroidism
Authors: Zhou Yihong , Chu Xi , Jiang Dong , Wu Xiang , Xu Jiarong , Qi Hao , Tang Yuxin , Dai Yingbo 
Published: August 2022

BackgroundNephrolithiasis is a common complication of primary hyperparathyroidism (PHPT), and the recurrence of nephrolithiasis in patients with PHPT is also an urgent concern. What is worse, there is a scarcity of recommended evaluation to predict the risk of nephrolithiasis recurrence in patients with PHPT. This study was aimed to develop and validate a nomogram to facilitate risk assessment in patients with PHPT.MethodsA total of 197 patients with PHPT were retrospectively included in this study from September 2016 to August 2021. Patients’ demographic data, blood test parameters, urinalysis, stone parameters, and surgical intervention were collected. Extracted variables were submitted to a least absolute shrinkage and selection operator (LASSO) regression model. A nomogram was built and validated according to the area under the curve (AUC) value, calibration curve, and decision curve analysis.ResultsAccording to the LASSO regression and logistic regression analyses, five predictors were derived from 22 variables: creatinine, uric acid, bilateral stone, multiplicity, and surgery. The AUC and concordance index of the training cohort and validation cohort were 0.829 and 0.856, and 0.827 and 0.877, respectively. The calibration curve analysis and the decision curve analysis showed that the nomogram had an adequate prediction accuracy.ConclusionWe built a useful nomogram model to predict the risk of nephrolithiasis recurrence in patients with PHPT. This would assist clinicians to provide appropriate advices and managements for these patients.
Prevalence of polycystic ovary syndrome in patients with type 2 diabetes: A systematic review and meta-analysis
Authors: Long Caiyi , Feng Haoyue , Duan Wen , Chen Xin , Zhao Yuemeng , Lan Ying , Yue Rensong 
Published: August 2022

PurposeWith type 2 diabetes mellitus (T2DM) occurring at a younger age, a greater number of women with T2DM experience reproductive health problems. The prevalence of polycystic ovary syndrome (PCOS), a common reproductive disease associated with T2DM, remains unknown in women with T2DM. This systematic review and meta-analysis aimed to determine the prevalence of PCOS in women with T2DM.MethodsStata 15.1 was used to perform a meta-analysis on the prevalence of PCOS in patients with T2DM included in this study. Additionally, a narrative review of the effects of different diagnostic methods, obesity, state, and other factors on the prevalence of PCOS was conducted.ResultsMeta-analysis showed that the overall prevalence of PCOS in women with T2DM was approximately 21%. Subgroup analysis showed that the incidence of PCOS in female patients aged 25-45 years was higher than that in female patients aged &lt; 25 years. The prevalence of PCOS in obese women was 14%, which was lower than that in normal weight women and normal weight or overweight or obese women. Women with T2DM in Oceania had the highest incidence of PCOS, followed by those in Europe and Asia; women with T2DM in North America had the lowest incidence. In terms of PCOS diagnostic standards, the prevalence of PCOS diagnosed by the National Institutes of Health was the lowest. The prevalence of PCOS diagnosed on the basis of clinical symptoms and biochemical characteristics was the highest, and the prevalence of PCOS diagnosed on the basis of medical records was 20%.ConclusionsPCOS is a common disease in female patients with T2DM. The prevalence of PCOS in women with T2DM at childbearing age was higher than that in adolescent females. Women with T2DM at childbearing age should pay attention to the screening and prevention of PCOS to avoid the hazards of PCOS to reproductive health.Systematic review registrationPROSPERO, identifier CRD42022318657.
PIEZO1 mechanoreceptor activation reduces adipogenesis in perivascular adipose tissue preadipocytes
Authors: Rendon C. Javier , Flood Emma , Thompson Janice M. , Chirivi Miguel , Watts Stephanie W. , Contreras G. Andres 
Published: August 2022

During hypertension, vascular remodeling allows the blood vessel to withstand mechanical forces induced by high blood pressure (BP). This process is well characterized in the media and intima layers of the vessel but not in the perivascular adipose tissue (PVAT). In PVAT, there is evidence for fibrosis development during hypertension; however, PVAT remodeling is poorly understood. In non-PVAT depots, mechanical forces can affect adipogenesis and lipogenic stages in preadipocytes. In tissues exposed to high magnitudes of pressure like bone, the activation of the mechanosensor PIEZO1 induces differentiation of progenitor cells towards osteogenic lineages. PVAT’s anatomical location continuously exposes it to forces generated by blood flow that could affect adipogenesis in normotensive and hypertensive states. In this study, we hypothesize that activation of PIEZO1 reduces adipogenesis in PVAT preadipocytes. The hypothesis was tested using pharmacological and mechanical activation of PIEZO1. Thoracic aorta PVAT (APVAT) was collected from 10-wk old male SD rats (n=15) to harvest preadipocytes that were differentiated to adipocytes in the presence of the PIEZO1 agonist Yoda1 (10 µM). Mechanical stretch was applied with the FlexCell System at 12% elongation, half-sine at 1 Hz simultaneously during the 4 d of adipogenesis (MS+, mechanical force applied; MS-, no mechanical force used). Yoda1 reduced adipogenesis by 33% compared with CON and, as expected, increased cytoplasmic Ca2+ flux. MS+ reduced adipogenesis efficiency compared with MS-. When Piezo1 expression was blocked with siRNA [siPiezo1; NC=non-coding siRNA], the anti-adipogenic effect of Yoda1 was reversed in siPiezo1 cells but not in NC; in contrast, siPiezo1 did not alter the inhibitory effect of MS+ on adipogenesis. These data demonstrate that PIEZO1 activation in PVAT reduces adipogenesis and lipogenesis and provides initial evidence for an adaptive response to excessive mechanical forces in PVAT during hypertension.
Setting thresholds of ecosystem structure and function to protect streams of the Brazilian savanna
Authors: Campos Camila Aida , Tonin Alan M. , Kennard Mark J. , Gonçalves Júnior José Francisco 
Published: August 2022

Freshwater environments are among the most threatened by human activities, consequently, their ecosystem structures and functions are targets of significant transformations. It makes monitoring an essential tool in the management of these environments. Ecological metrics have been proven to be effective in monitoring programs aimed at assessing freshwater ecosystem integrity. Structural and functional aspects of the ecosystem may allow for a comprehensive view of the multiple human impacts that occur at different scales. However, a gap in the effective use of such ecological tools lies in the identification of the relative importance of different mechanisms that cause impacts and the interactions between them. Using Boosted Regression Tree (BRT) models, we evaluated the relative importance of natural and human impact factors, from local to catchment scales, on metrics related to diatom and macroinvertebrate assemblages and ecosystem processes. The study was carried out in 52 stream reaches of the Brazilian savanna in central Brazil. Conductivity was the most relevant factor to explain the variation of ecological metrics. In general, macroinvertebrate metrics and algal biomass production responded to both water quality and land use factors, while metrics of diatoms and microbial biomass responded more strongly to water quality variables. The nonlinear responses allowed the detection of gradual or abrupt-changes curves, indicating potential thresholds of important drivers, like conductivity (100–200 µS cm−1), phosphate (0.5 mg L−1) and catchment-scale urbanization (10–20%). Considering the best performance models and the ability to respond rather to stress than to natural factors, the potential bioindicators identified in the study area were the macroinvertebrates abundance, the percentage of group Ephemeroptera/Plecoptera/Trichoptera abundance, the percentage of group Oligochaeta/Hirudinea abundance, the percentage of genus Eunotia abundance, the Trophic Diatom Index and the algal biomass production. The results reinforced the importance of consider in the national monitoring guidelines validated ecological thresholds. Thus, maintaining the balance of aquatic ecosystems may finally be on the way to being achieved.
Risk of HBV reactivation in relapsed or refractory diffuse large B-cell lymphoma patients receiving Bruton tyrosine kinase inhibitors therapy
Authors: Ni Ying , Gao Lixia , Lu Yan , Ye Shiguang , Zhou Lili , Qian Wenbin , Liang Aibin , Li Ping 
Published: August 2022

BackgroundBruton tyrosine kinase inhibitors (BTKis) interrupt B-cell receptor signaling and thereby could potentially reactivate hepatitis B virus (HBV). However, data about the risk for HBV reactivation (HBVr) of BTKis in relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL) patients are sparse.MethodsA total of 55 R/R DLBCL patients receiving BTKis therapy in the Tongji Hospital of Tongji University were enrolled. Patient clinical characteristics, treatment outcomes and details of HBVr were collected and analyzed, aiming to demonstrate the risk of HBVr in R/R DLBCL patients post BTKis therapy and the efficacy of BTKis in HBV-associated R/R DLBCL patients.ResultsOf 55 R/R DLBCL patients treated with ibrutinib (N=38) and zanubrutinib (N=17), 4 were with chronic HBV infection (HBsAg positive), 26 with resolved HBV infection (HBsAg negative and HBcAb positive) and 25 without HBV infection (HBsAg negative and HBcAb negative). In resolved HBV infection group, 2 patients developed HBVr after the use of ibrutinib and zanubrutinib respectively. Neither of them developed HBV-related hepatitis. Our finding showed that the incidence of HBVr in resolved HBV infection group was 7.69% (95% CI, 0.9-25.1%). In this study, Overall response rate (ORR) was 70.9%. 1-year overall survival (OS) rate was 80.0%. Median progression-free survival (PFS) was 4 months (95% CI, 3-5 months). In addition, HBV infection was not associated with response rates or survival among R/R DLBCL patients post BTKis treatments.ConclusionOur study suggested that HBV infection do not affect the efficacy of BTKis’ treatment. However, R/R DLBCL patients with resolved HBV infection are at a moderate risk of developing HBVr throughout BTKis treatment. Patients should be screened for HBVr during BTKis therapy.