bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Antara Rasio Lingkar Pinggang dan Panggul (RLPP) dengan Derajat Nyeri pada Pasien Osteoartritis Lutut di RS UNS
Authors: Adissa Dinda Khairunnisa  , Kurniawati Tandiyo Desy , Hastami Yunia 
Published: March 2022

Pendahuluan: Osteoartritis lutut merupakan gangguan sendi kronis yang prevalensinya cukup tinggi. Obesitas sering dikaitkan sebagai salah satu faktor risiko OA lutut dan menyebabkan peningkatan intensitas nyeri pada pasien. RLPP dapat digunakan sebagai indikator pengukuran obesitas yang dianggap lebih sensitif untuk mengetahui distribusi lemak pada bagian tubuh. Penelitian ini dilakukan untuk menilai hubungan antara rasio lingkar pinggang dan panggul (RLPP) dengan rerajat nyeri pada pasien osteoartritis lutut di RS UNS. Metode: Penelitian yang dilakukan adalah penelitian observasional analitik dengan pendekatan cross sectional. Terdapat 47 pasien osteoartritis lutut yang berobat ke Instalasi Rehabilitasi Medik RS UNS dari tanggal 7 Juni - 19 Juli 2021 dan 25 diantaranya merupakan subjek penelitian. Variabel terikat penelitian adalah derajat nyeri OA yang diukur menggunakan kuisioner numerical rating scale (NRS). Variabel bebas penelitian adalah rasio lingkar pinggang dan panggul (RLPP) yang diukur menggunakan pita ukur. Hubungan antar variabel diuji menggunakan uji korelasi Spearman. Hasil: Tidak terdapat hubungan yang signifikan antara RLPP dengan derajat nyeri pada pasien osteoartritis lutut di RS UNS (p = 0,118). Kesimpulan: Tidak terdapat hubungan yang antara RLPP dengan derajat nyeri pada pasien osteoartritis lutut di RS UNS. Kata Kunci: Osteoartritis Lutut; Rasio Lingkar Pinggang dan Panggul; Derajat Nyeri. ABSTRACT Introduction: Knee osteoarthritis is a chronic joint disorder with a quite high prevalence. Obesity is often associated as a risk factor for knee OA and causes an increase of pain intensity in patients. Waist-to-hip ratio (WHR) can be used as an indicator of obesity which is considered more sensitive to determine the distribution of fat in the body. This study was conducted to assess the correlation between waist-to-hip circumference ratio (WHR) and the degree of pain in patients with knee osteoarthritis at UNS Hospital.. Methods: This research was analytic observational study with a cross sectional approach. There were 47 patients who went to Installation of Medical Rehabilitation at UNS Hospital from 7 June - 19 July 2021 and 25 of them were research subjects. The dependent variable of the study was degree of pain which was measured using a numerical rating scale (NRS) questionnaire. The independent variable of the study was waist-to-hip circumference (WHR) which was measured using a measuring tape. The correlation between variables was tested using Rank Spearman Correlation Test. Results: There was no significant correlation between WHR and degree of pain in patients with knee osteoarthritis at UNS Hospital (p = 0,118). Conclusion: There is no correlation between WHR and degree of pain in patients with knee osteoarthritis at UNS Hospital. Keywords: Knee Osteoarthritis; Degree of Pain; Waist-to-Hip Ratio
Efficacy of Hyaluronic Acid Injections in the Treatment of Osteoarthritis of the Knee
Authors: Trimm Erica 
Published: March 2022

Background:
Hyaluronic acid injections for treatment of osteoarthritis of the knee are a widely used yet highly controversial therapy. Many societal guidelines recommend against the use of such injections.

Objective:
This review aims to investigate efficacy of intra-articular hyaluronic acid injections for treatment of osteoarthritis of the knee.

Conclusion:
There are many factors impacting the efficacy of intra-articular hyaluronic acid injections. This can include source of hyaluronic acid, dosing regimen, molecular weight of the product, and patient characteristics. Overall, hyaluronic acid injections can be effective in reducing pain and improving physical function in patients with osteoarthritis of the knee. These injections may also prolong time between diagnosis and arthroplasty. Adverse events after injection are rare and can be product-related. Radiologic findings and severity of disease can be predictive of successful treatment outcomes. More consistent research will be necessary to overturn societal guideline recommendations to support treatment with intra-articular hyaluronic acid products.
Building a Transdisciplinary Expert Consensus on the Cognitive Drivers of Performance Under Pressure: An International Multi-panel Delphi Study
Authors: Albertella Lucy , Kirkham Rebecca , Adler Amy , Crampton John , Drummond Sean , Fogarty Gerard , Gross James , Zaichkowsky Leonard , Andersen Judith , Bartone Paul (T) , Boga Danny , Bond Jeffrey , Brunyé Tad , Campbell Mark , Ciobanu Liliana , Clark Scott , CRANE Monique , Dietrich Arne , Doty Tracy , Driskell James , Fahsing Ivar , Fiore Stephen , Flin Rhona , Funke Joachim , Gatt Justine , Hancock Peter , Harper Craig , Heathcote Andrew , Heaton Kristin , Helsen Werner , Hussey Erika , Jackson Rob , Khemlani Sangeet , Killgore William , Kleitman Sabina , Lane Andrew , Loft Shayne , MacMahon Clare , Marcora Samuele , McKenna Frank , Meijen Carla , Moulton Vanessa , Moyle Gene , Nalivaiko Eugene , O’Connor Donna , O’Conor Dorothea , Patton Debra , Piccolo Mark , Ruiz Coleman , Schücker Linda , Smith Ronald , Smith Sarah , Sobrino Chava , Stetz Melba , Stewart Damien , Taylor Paul , Tucker Andrew , Stralen Haike van , Vickers Joan , Visser Troy , Walker Frederick , Wiggins Mark , Williams Mark , Wong Leonard , Aidman Eugene , Yucel Murat 
Published: March 2022

Abstract
The ability to perform optimally under pressure is critical across many occupations, including the military, first responders, and competitive sport, and depends on a range of cognitive factors. How common these key performance factors are across application domains remains unclear. The current study sought to integrate existing knowledge in the performance field in the form of a transdisciplinary expert consensus on the cognitive mechanisms that underlie performance under pressure. International experts were recruited from four performance domains (i. Defence; ii. Competitive Sport; iii. Civilian High-stakes; and iv. Performance Neuroscience). Experts rated constructs from the Research Domain Criteria (RDoC) framework (in addition to several expert-suggested constructs) across successive rounds, until all constructs reached consensus for inclusion or were eliminated. Finally, included constructs were ranked for their relative importance. Sixty-eight experts completed the first Delphi round, with 94% of experts retained by the end of the Delphi process. Seven of the ten constructs that reached transdisciplinary consensus came from the Cognitive Systems domain including: 1) Attention; 2) Cognitive Control—Goal Selection, Updating, Representation & Maintenance; 3) Cognitive Control—Performance Monitoring; 4) Cognitive Control—Response Selection & Inhibition/Suppression; 5) Working memory—Flexible Updating; 6) Working memory—Active Maintenance; and 7) Working memory—Interference Control. Other constructs that reached transdisciplinary consensus were Self-knowledge, Arousal, and Shifting (an expert-suggested construct). Our results identify a set of transdisciplinary neuroscience-informed constructs, validated through Delphi consensus. This expert consensus is critical to standardising cognitive assessment and informing mechanism-targeted interventions in the broader field of human performance optimisation.
The Expression of YKL-40 in The Peripheral Blood of Colorectal Cancer Patients and its Effect on The Proliferation and Angiogenesis of Colorectal Cancer Cells
Authors: yang shaohui , shen jie , zhao yibin 
Published: March 2022

Abstract
Objective To observe the expression of YKL-40 in the serum of patients with colorectal cancer and to study the effect of the YKL-40 gene on the proliferation and angiogenesis of colon cancer cell lines. Methods Serum samples of 79 patients with colorectal cancer before and 7 days after surgery, 13 patients with precancerous lesions and 21 healthy controls were collected, and the expression of YKL-40 was detected by enzyme-linked immunosorbent assays (ELISAs). The HCT116 cell line with high expression of YKL-40 was selected from the colon cancer cell lines HCT-15, HCT116 and SW480, and then, HCT116 cells were divided into an experimental group and a control group. The expression of the YKL-40 gene in the experimental group was inhibited by small interfering RNA (siRNA), and the high expression of YKL-40 in the control group was maintained. Then, the cells in the two groups were cocultured with bevacizumab. Cell proliferation was detected by CCK-8 assays, and angiogenesis was detected by cell formation assays. Results The mean values of serum YKL-40 in the colorectal cancer group (preoperative), the precancerous lesion group and the control group were 178.50±71.91 μg/L, 95.18±33.56 μg/L and 85.47±24.97 μg/L, respectively. The colorectal cancer group (preoperative) had a significantly higher value than the precancerous lesion group and the control group (P <0.01). The precancerous lesion group had a higher value than the control group, but the difference between the two was not significant (P= 0.265). The expression of YKL-40 was positively correlated with the stage of colorectal cancer (P<0.05). There was no significant difference in the expression of serum YKL-40 before and after surgery (P=0.07). HCT116 is a cell line with high YKL-40 expression. After the expression of this gene was inhibited, the survival rate of the experimental group was 78.75%, which was significantly lower than that of the control group (P<0.05). The angiogenesis test was used to detect the angiogenic ability. Both siRNA targeting the YKL-40 gene and the addition of bevacizumab inhibited angiogenesis in vitro. Moreover, the vascular inhibitory effect of bevacizumab in the group with low expression of YKL-40 was stronger than that in the group with high expression of YKL-40. Conclusion YKL-40 is highly expressed in the peripheral blood of patients with colorectal cancer and is related to tumour stage. The HCT116 colon cancer cell line highly expresses YKL-40. Interfering with the expression of YKL-40 can inhibit cell proliferation and angiogenesis. This finding suggests that YKL-40 plays an important role in the occurrence and development of colorectal cancer.
A probability crossover based complete elitist genetic algorithm for drug scheduling to minimize tumor cells in cancer chemotherapy
Authors: Das Kedar Nath , Ahmed Afsana Zannat , Acharjya D. P. 
Published: March 2022

Abstract
In the United States, there is one death out of every four due to cancer. Cancer chemotherapy is one of the few practices adopted for the treatment of this disease that uses anti-cancer drugs. However cancer chemotherapy comes hand in hand with a large number of side effects due to which the patients being unable to bear it leave the treatment in the midway. In day to day life, it is not possible to find a chemotherapy drug regime which is free of side effects. In the present work, an attempt is made to design a suitable cancer chemotherapy drug regime with the help of elitist Genetic Algorithm (GA) with side effects as minimum as possible. This present works proposes a drug schedule so that the number of cancer cells is reduced over the period of treatment interval and the toxic side effects are to be minimum as well. In order to increase the robustness of the proposed algorithm, the GA operators like crossover and mutation has been suitably investigated over their possible permutations. A complete elitism has been employed at the end of each GA cycle that helps to retain the good individuals for the next iteration. Based on the numerical results and statistical analysis the out performance of elitist GA has been substantiated to be better competent over the state-of-the-art techniques in finding optimal drug scheduling in cancer chemotherapy.
Insights Into Volcanic Unrest by Correlating Petrological and Seismic Observations at Kizimen (Kamchatka, Russia)
Authors: Ostorero Lea , Balcone-Boissard Hélène , Boudon Georges , Shapiro Nikolai , Belousov Alexander , Belousova Marina , Auer Andreas , Senyukov Sergey , Droznina Svetlana 
Published: March 2022

Abstract
The increase of number and intensity of earthquakes during a pre-eruptive crisis is the main basis of seismic volcano monitoring. However, the exact relationship between the seismic activity and the volcano-magmatic processes remains unclear. Here we present a direct comparison between characteristics of a seismo-volcanic crisis recorded prior to the 2010-2013 eruption of Kizimen volcano (Kamchatka, Russia) and the timescales of processes in the magma plumbing system. These timescales are inferred from the modelling of Fe-Mg intracrystalline interdiffusion in 88 zoned orthopyroxene crystals from dacites and silica-rich andesites samples collected after the eruption. We show that the eruptible magmas were assembled rapidly during a magma mixing episode ~1.5 years before the eruption, which is well correlated with the onset of a seismic crisis. We conclude that the observed seismic re-activation marks the onset of magma mixing leading to destabilization of the reservoir followed by the eruption after ~1.5 years.
Activity tracker-based intervention to increase physical activity in patients with type 2 diabetes and healthy individuals: study protocol for a randomized controlled trial
Authors: Mähs Mareike , Pithan Jana Sabrina , Bergmann Isabell , Gabrys Lars , Graf Jonathan , Hölzemann Alexander , Laerhoven Kristof Van , Otto-Hagemann Silke , Popescu Maria Loredana , Schwermann Lisa , Wenz Benjamin , Pahmeier Iris , Teti Andrea 
Published: March 2022

Abstract
Background
One relevant strategy to prevent the onset and progression of type 2 diabetes mellitus (T2DM) focuses on increasing physical activity. The use of activity trackers by patients could enable objective measurement of their regular physical activity in daily life and promote physical activity through the use of a tracker-based intervention. This trial aims to answer three research questions: (1) Is the use of activity trackers suitable for longitudinal assessment of physical activity in everyday life? (2) Does the use of a tracker-based intervention lead to sustainable improvements in the physical activity of healthy individuals and in people with T2DM? (3) Does the accompanying digital motivational intervention lead to sustainable improvements in physical activity for participants using the tracker-based device?
Methods
The planned study is a randomized controlled trial focused on 1,642 participants with and without T2DM for 9 months with regard to their physical activity behavior. Subjects allocated to an intervention group will wear an activity tracker. Half of the subjects in the intervention group will also receive an additional digital motivational intervention. Subjects allocated to the control group will not receive any intervention. The primary outcome is the amount of moderate and vigorous physical activity in minutes and the number of steps per week measured continuously with the activity tracker and assessed by questionnaires at four time points. Secondary endpoints are medical parameters measured at the same four time points. The collected data will be analyzed using inferential statistics and explorative data-mining techniques.
Discussion
The trial uses an interdisciplinary approach with a team including sports psychologists, sports scientists, health scientists, health care professionals, physicians, and computer scientists. It also involves the processing and analysis of large amounts of data collected with activity trackers. These factors represent particular strengths as well as challenges in the study.
Trial Registration
The trial is registered at the World Health Organization International Clinical Trials Registry Platform via the German Clinical Studies Trial Register (DRKS), DRKS00027064. Registered on 11 November 2021.
Dynamic QTL-Based Ecophysiological Models to Predict Phenotype from Genotype and Environment Data
Authors: Vallejos C. Eduardo , Jones James W. , Bhakta Mehul S. , Gezan Salvador A. , Correll Melanie J. 
Published: March 2022

Abstract
BackgroundPredicting the phenotype from the genotype is one of the major contemporary challenges in biology. This challenge is greater in plants because their development occurs mostly post-embryonically under diurnal and seasonal environmental fluctuations. Most current crop simulation models are physiology-based models capable of capturing environmental fluctuations but cannot adequately capture genotypic effects because they were not constructed within a genetics framework. ResultsWe describe the construction of a mixed-effects dynamic model to predict time-to-flowering in the common bean (Phaseolus vulgaris L.). This prediction model applies the developmental approach used by traditional crop simulation models, uses direct observational data, and captures the Genotype, Environment, and Genotype-by-Environment effects to predict progress towards time-to-flowering in real time. Comparisons to a traditional crop simulation model and to a previously developed static model shows the advantages of the new dynamic model.ConclusionsThe dynamic model can be applied to other species and to different plant processes. These types of models can, in modular form, gradually replace plant processes in existing crop models as has been implemented in BeanGro, a crop simulation model within the DSSAT Cropping Systems Model. Gene-based dynamic models can accelerate precision breeding of diverse crop species, particularly with the prospects of climate change. Finally, a gene-based simulation model can assist policy decision makers in matters pertaining to prediction of food supplies.
Benzimidazole and aminoalcohol derivatives show in vitro anthelmintic activity against Trichuris muris and Heligmosomoides polygyrus
Authors: Valladares Maria Martinez , Valderas-García Elora , Häberli Cécile , Bardón María Álvarez , Escala Nerea , de Agüero Verónica Castilla Gómez , Vega Jennifer de la , Olmo Esther del , Balaña-Fouce Rafael , Keiser Jennifer 
Published: March 2022

Abstract
Background: Infections by gastrointestinal nematodes cause significant economic losses and disease in both human and animals worldwide. The discovery of novel anthelmintic drugs is crucial for maintaining control of these parasitic infections.Methods: For this purpose, the aim of the present study was to evaluate the potential anthelmintic activity of three series of compounds against the gastrointestinal nematodes Trichuris muris and Heligmosomoides polygyrus in vitro. The compounds tested were derivatives of benzimidazole, lipidic aminoalcohols and diamines. A primary screening was performed to select those compounds with an ability to inhibit T. muris L1 motility by more than 90% at a single concentration of 100 µM, and then, their respective IC50 values were calculated. Those compounds with IC50 lower than 10 µM were also tested against the adult stage of T. muris and H. polygyrus at a single concentration of 10µM. Results: Of the 41 initial compounds screened, only compounds AO14, BZ6 and BZ12 had IC50 values lower than 10 µM on T. muris L1 assay, showing IC50 values of 3.30, 8.89 and 4.17 µM, respectively. However, only two of them displayed activity against the adult stage of the parasites: BZ12 killed 81% of adults of T. muris (IC50 of 8.1 µM) and 53% of H. polygyrus while BZ6 killed 100% of H. polygyrus adults (IC50 of 5.3 µM) but only 17% of T. muris. Conclusions: BZ6 and BZ12 could be considered as potential candidates for further in vivo efficacy testing.
Improving appearance and mechanical strength of aluminum-polypropylene/talc composite friction stir joint using a novel tool design
Authors: Shiravi Hosseinali , Movahedi Mojtaba , Ozlati Ashkaan 
Published: March 2022

Abstract
In this research, friction stir joining of aluminum-polypropylene/talc composite was investigated due to the numerous applications of aluminum-polymer joints in automotive and aerospace industry. A novel tool design, including a rotary/stationary holder was used to improve the appearance and mechanical performance of friction stir lap joints by preventing the mixed molten polymer and aluminum particles from exiting the stirred zone. Effect of tool transverse speed on the joint microstructure and strength was investigated. Using the rotary/stationary holder, tensile-shear strength of the joints increased (by ~45% to ~220% at various transverse speeds). Since during the tensile-shear test, all joints failed from the aluminum/stirred zone interface, joint strength was affected by the formation of anchor-like aluminum pieces in the composite substrate as the mechanical locks, reaction layer at the joint interface and large voids near the aluminum/stirred zone interface. Joining at the optimum transverse speed led to the highest tensile-shear peak load of 315 N.
Selective C(sp3)-C(sp3) reduction and metathesis of ketones
Authors: Wang Shengke , Wang Yitu , Yang Yan , Hu Kun , Lou Dingkai , Wang Kai , Maron Laurent , Zhou Xigeng 
Published: March 2022

Abstract
The C–C bond reduction and metathesis are fundamentally important in organic synthesis. However, homogeneously reducible C–C bonds are currently limited to either strained rings or to specific and prefunctionalized sites; and there are no practical methods for tandem C–C reduction and intramolecular C(sp3)–C(sp3) metathesis. Here we report a versatile approach for selective reduction of unstrained C(sp3)–C(sp3) bond of ketones, including hydrogenolytic retro-[2+2+2]-cycloreversion of 2,4-diaroylcyclohexanols, without requiring protecting groups. We have also established an unprecedented intramolecular C(sp3)–C(sp3) metathesis, thus enabling the cyclizative degradation of poly(vinylketone). The present C–C cleavage occurs via a bimetallic pathway and nucleophile trapping of resulting enone is crucial for C–C cleavage relay. These results would open new prospect for deconstruction of organic molecules.