bluuebunny/crossref_metadata_2025_split huggingface dataset:
Augmented anticancer effect and antibacterial activity of silver nanoparticles synthesized by using Taxus wallichiana leaf extract
Authors: Yousaf Aliya , Waseem Muhammad , Javed Aneela , Baig Sofia , Ismail Bushra , Baig Ayesha , Shahzadi Irum , Nawazish Shamyla , Zaman Iftikhar 
Published: November 2022

Background
Taxus wallichiana is an evergreen tree species found in the Himalayan region of Pakistan. The tree possesses important secondary metabolites such as Taxol that has been implicated in treating breast, ovarian and colon cancer. Therefore keeping in view the importance of this plant species, silver nanoparticles were synthesized using Taxus wallichiana aqueous leaf extract and evaluated for their anti-bacterial and anti-cancer properties.

Methods
Silver (Ag) nanoparticles (NPs) were characterized for their optical, morphological and structural features using techniques such as UV-visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) and were evaluated for their antibacterial activity and anti-cancer activity using U251 cell line.

Results
The study showed that the UV-absorbance peak of Ag2O NPs at 450 nm shifted to 410 nm, affirming the formation of leaf extract Ag NPs. Similarly structural studies revealed the crystalline nature of the cubic structure of the Ag crystal with an average crystallite size of 29 nm. FTIR analysis exhibited the existence of different functional elements including O-H and N-H and phenolic groups. Non-spherical glomerular shaped Taxus wallichiana Ag NPs were observed from SEM studies and EDX profile showed Ag as the main element along with constituent of biological origin. The synthesized Ag NPs showed significant antibacterial activity against Salmonella typhi, and Staphylococcus aureus. The cytotoxic activity of Ag NPs on U251 brain cancer cells showed a synergistic effect with 10 ug/mL concentration after 48 and 72 h incubation based on cell viability assay indicating promising glioblastoma drug potential.
Sentiment Analysis for Market Survey in the Framework of the Establishment of the IT Boarding School Vocational School
Authors: Fernandes Adji Achmad Rinaldo 
Published: November 2022

Aims: This study aims to obtain indicators which are then compiled in a questionnaire research instrument which will later be used in further analysis namely sentiment analysis.
Methodology: Sentiment analysis is a method used to identify how a sentiment is expressed using text and how that sentiment can be categorized as positive sentiment or negative sentiment. Boarding school. So that researchers can conclude whether the sentiments or issues that arise in the tweets published by the surrounding community on social media are more supportive or even less supportive regarding the boarding school program at a boarding school.
Results: The findings of this study are the variables that can be used in further research, namely marketing communication strategies, marketing mix, and interest in learning.
Conclusion: Based on the sentiment analysis, it was found that society has a neutral tendency regarding public perceptions in Indonesia regarding the boarding school program at a boarding school.
Risk of Cardiovascular Diseases Associated With Medications Used in Attention-Deficit/Hyperactivity Disorder
Authors: Zhang Le , Yao Honghui , Li Lin , Du Rietz Ebba , Andell Pontus , Garcia-Argibay Miguel , D’Onofrio Brian M. , Cortese Samuele , Larsson Henrik , Chang Zheng 
Published: November 2022

ImportanceUse of attention-deficit/hyperactivity disorder (ADHD) medications has increased substantially over the past decades, but there are concerns regarding their cardiovascular safety.ObjectiveTo provide an updated synthesis of evidence on whether ADHD medications are associated with the risk of a broad range of cardiovascular diseases (CVDs).Data SourcesPubMed, Embase, PsycINFO, and Web of Science up to May 1, 2022.Study SelectionObservational studies investigating the association between ADHD medications (including stimulants and nonstimulants) and risk of CVD.Data Extraction and SynthesisIndependent reviewers extracted data and assessed study quality using the Good Research for Comparative Effectiveness (GRACE) checklist. Data were pooled using random-effects models. This study is reported according to the Meta-analyses of Observational Studies in Epidemiology guideline.Main Outcomes and MeasuresThe outcome was any type of cardiovascular event, including hypertension, ischemic heart disease, cerebrovascular disease, heart failure, venous thromboembolism, tachyarrhythmias, and cardiac arrest.ResultsNineteen studies (with 3 931 532 participants including children, adolescents, and adults; 60.9% male), of which 14 were cohort studies, from 6 countries or regions were included in the meta-analysis. Median follow-up time ranged from 0.25 to 9.5 years (median, 1.5 years). Pooled adjusted relative risk (RR) did not show a statistically significant association between ADHD medication use and any CVD among children and adolescents (RR, 1.18; 95% CI, 0.91-1.53), young or middle-aged adults (RR, 1.04; 95% CI, 0.43-2.48), or older adults (RR, 1.59; 95% CI, 0.62-4.05). No significant associations for stimulants (RR, 1.24; 95% CI, 0.84-1.83) or nonstimulants (RR, 1.22; 95% CI, 0.25-5.97) were observed. For specific cardiovascular outcomes, no statistically significant association was found in relation to cardiac arrest or arrhythmias (RR, 1.60; 95% CI, 0.94-2.72), cerebrovascular diseases (RR, 0.91; 95% CI, 0.72-1.15), or myocardial infarction (RR, 1.06; 95% CI, 0.68-1.65). There was no associations with any CVD in female patients (RR, 1.88; 95% CI, 0.43-8.24) and in those with preexisting CVD (RR, 1.31; 95% CI, 0.80-2.16). Heterogeneity between studies was high and significant except for the analysis on cerebrovascular diseases.Conclusions and RelevanceThis meta-analysis suggests no statistically significant association between ADHD medications and the risk of CVD across age groups, although a modest risk increase could not be ruled out, especially for the risk of cardiac arrest or tachyarrhythmias. Further investigation is warranted for the cardiovascular risk in female patients and patients with preexisting CVD as well as long-term risks associated with ADHD medication use.
Tailoring Optical Properties in Transparent Highly Conducting Perovskites by Cationic Substitution
Authors: Mohammadi Mahdad , Xie Ruiwen , Hadaeghi Niloofar , Radetinac Aldin , Arzumanov Alexey , Komissinskiy Philipp , Zhang Hongbin , Alff Lambert 
Published: November 2022

AbstractSrMoO3 , SrNbO3, and SrVO3 are remarkable highly conducting d1 (V, Nb) or d2 (Mo) perovskite metals with an intrinsically high transparency in the visible. A key scientific question is how the optical properties of these materials can be manipulated to make them suitable for applications as transparent electrodes and in plasmonics. Here, it is shown how 3d/4d cationic substitution in perovskites tailors the relevant materials parameters, i.e., optical transition energy and plasma frequency. With the example of the solid‐state solution SrV1−xMoxO3, it is shown that the absorption and reflection edges can be shifted to the edges of the visible light spectrum, resulting in a material that has the potential to outperform indium tin oxide (ITO) due to its extremely low sheet resistance. An optimum for x = 0.5, where a resistivity of 32 µΩ cm (≈12 Ω sq−1) is paired with a transmittance above 84% in the whole visible spectrum is found. Quantitative comparison between experiments and electronic structure calculations show that the shift of the plasma frequency is governed by the interplay of d‐band filling and electronic correlations. This study advances the knowledge about the peculiar class of highly conducting perovskites toward sustainable transparent conductors and emergent plasmonics.
Nickel Metallaphotoredox Catalysis Enabling Desulfurative Cross Coupling Reactions
Authors: Geniller Lilian , Taillefer Marc , Jaroschik Florian , Prieto Alexis 
Published: November 2022

AbstractMetallaphotoredox processes have emerged as powerful methods for C−C bond formations. The Ni‐photoredox catalyzed desulfurative cross‐coupling of thiol derivatives with aryl bromides has now been established. This procedure provides access to simple and complex unsymmetrical diarylmethane molecules under mild reaction conditions with a broad functional group tolerance. The key steps of the reaction involve a silane‐mediated halogen‐atom transfer (XAT) and a subsequent intramolecular homolytic substitution (SH), formingC‐centered radicals from various thiol derivatives as shown by mechanistic studies. This study paves the way for new transformations of abundant, naturally occurring thiols.magnified image
[EMmim][NTf2]—a Novel Ionic Liquid (IL) in Catalytic CO2 Capture and ILs’ Applications
Authors: He Xin , Gao Yangyan , Shi Yunlei , Zhang Xiaowen , Liang Zhiwu , Zhang Riguang , Song Xingfei , Lai Qinghua , Adidharma Hertanto , Russell Armistead G. , Eddings Eric G. , Fei Weiyang , Cheng Fangqin , Tsang Shik Chi Edman , Wang Jianji , Fan Maohong 
Published: November 2022

AbstractIonic liquids (ILs) have been used for carbon dioxide (CO2) capture, however, which have never been used as catalysts to accelerate CO2 capture. The record is broken by a uniquely designed IL, [EMmim][NTf2]. The IL can universally catalyze both CO2 sorption and desorption of all the chemisorption‐based technologies. As demonstrated in monoethanolamine (MEA) based CO2 capture, even with the addition of only 2000 ppm IL catalyst, the rate of CO2 desorption—the key to reducing the overall CO2 capture energy consumption or breaking the bottleneck of the state‐of‐the‐art technologies and Paris Agreement implementation—can be increased by 791% at 85 °C, which makes use of low‐temperature waste heat and avoids secondary pollution during CO2 capture feasible. Furthermore, the catalytic CO2 capture mechanism is experimentally and theoretically revealed.
What determines the evolutionary trajectories of wild plant species? Approaches to the study of quantitative fitness‐related traits
Authors: Mazer Susan J. , Sakai Ann K. , Weller Stephen G. , Larios Eugenio 
Published: November 2022

AbstractWild plant species provide excellent examples of qualitative traits that evolve in response to environmental challenges (e.g., flower color, heavy metal tolerance, cyanogenesis, and male sterility). In addition to such discrete characters, a dazzling array of continuously distributed, quantitative traits are expressed at every phase of the life cycle. These traits are known or suspected to have evolved by natural selection because they are heritable, differ among populations or closely related taxa occupying distinct habitats, and have individual phenotypes associated with survival and reproductive success. This special issue [American Journal of Botany 109(11)] focuses on the tools and approaches for detecting or inferring the ecological and genetic factors contributing to changes in genetically based variation of quantitative traits within or among populations, or causing their divergence among taxa. The assembled articles use one or more of three primary approaches to detect the process or outcome of natural selection on morphological, life history, reproductive, chemical, and physiological quantitative traits: the analysis of phenotypic or artificially imposed selection to detect direct and indirect selection on traits whose function is well‐understood; common garden experiments, including reciprocal transplants and “resurrection” experiments; and quantitative genetic analyses designed to detect and to estimate the environmental and genetic sources of phenotypic variation or to forecast short‐term evolutionary change. Together, these articles examine and reveal the adaptive capacity of quantitative traits and the genetically based constraints that may limit their directional evolutionary change, thereby informing and testing inferences, hypotheses, and predictions concerning the evolutionary trajectories of wild plant species.
Congenital diaphragmatic hernia in Coffin Siris syndrome: Further evidence from two cases
Authors: Rimoldi Martina , Rinaldi Berardo , Villa Roberta , Cerasani Jacopo , Beltrami Benedetta , Iascone Maria , Silipigni Rosamaria , Boito Simona , Gangi Silvana , Colombo Lorenzo , Porro Matteo , Cesaretti Claudia , Bedeschi Maria Francesca 
Published: November 2022

AbstractCoffin‐Siris Syndrome (CSS) is a rare multi‐system dominant condition with a variable clinical presentation mainly characterized by hypoplasia/aplasia of the nail and/or distal phalanx of the fifth digit, coarse facies, hirsutism/hypertrichosis, developmental delay and intellectual disability of variable degree and growth impairment. Congenital anomalies may include cardiac, genitourinary and central nervous system malformations whereas congenital diaphragmatic hernia (CDH) is rarely reported. The genes usually involved in CSS pathogenesis are ARID1B (most frequently), SMARCA4, SMARCB1, ARID1A, SMARCE1, DPF2, and PHF6. Here, we present two cases of CSS presenting with CDH, for whom Whole Exome Sequencing (WES) identified two distinct de novo heterozygous causative variants, one in ARID1B (case 1) and one in SMARCA4 (case 2). Due to the rarity of CDH in CSS, in both cases the occurrence of CDH did not represent a predictive sign of CSS but, on the other hand, prompted genetic testing before (case 1) or independently (case 2) from the clinical hypothesis of CSS. We provide further evidence of the association between CSS and CDH, reviewed previous cases from literature and discuss possible functional links to related conditions.
The role of nitric oxide in the dorsomedial periaqueductal gray (dmPAG) column in cardiovascular responses in urethane‐anesthetized male rats
Authors: Najaftomaraei Mohammad , Ghorbani Atiyeh , Rahimi Alireza , Mohebbati Reza , Sherkat Sogol , Shafei Mohammad Naser 
Published: November 2022

AbstractBackgroundThe dorsomedial periaqueductal gray (dmPAG) is a mesencephalic area and has numerous functions including cardiovascular regulation. Because nitric oxide (NO) is present in the dmPAG, here we investigate, the probable cardiovascular effect of NO in the dmPAG.MethodsFive groups (n = 6 for each group) were used as follows: (1) control; (2) L‐NAME (NG‐nitro‐L‐arginine methyl ester, a NO synthase inhibitor, 90 nmol); (3) L‐arginine (L‐Arg, a precursor for NO, 60 nmol); (4) Sodium nitroprusside (SNP, a NO donor, 27 nmol); and (5) L‐Arg + L‐NAME. The cardiovascular parameters were recorded by a Power Lab device after cannulation of the femoral artery. Drugs were injected using a stereotaxic instrument. The changes (∆) in systolic blood pressure (SBP), mean arterial pressure (MAP), and heart rate (HR) were calculated at different times and compared to the control group.ResultsMicroinjection of L‐NAME significantly increased ∆SBP, ∆MAP, and ∆HR more than saline (from p < 0.05 to p < 0.001). L‐Arg only significantly increased ∆HR (p < 0.05). In the L‐Arg + L‐NAME group, the above parameters also significantly increased (from p < 0.01 to p < 0.05) but not as significantly as with L‐NAME alone. Microinjection of SNP significantly decreased ∆SBP and ∆MAP more than in the control and L‐NAME groups (from p < 0.01 to p < 0.001), but ∆HR did not change significantly.ConclusionThe results indicated that NO in dmPAG has an inhibitory effect on cardiovascular responses in anesthetized rats.
Wacker Oxidation of Methylenecyclobutanes: Scope and Selectivity in an Unusual Setting
Authors: Sietmann Jan , Tenberge Marius , Wahl Johannes M. 
Published: November 2022

AbstractMethylenecyclobutanes are found to undergo Wacker oxidation via a semi‐pinacol‐type rearrangement. Key to a successful process is the use of tert‐butyl nitrite as oxidant, which not only enables efficient catalyst turn‐over but also ensures high Markovnikov‐selectivity under mild conditions. Thus, cyclopentanones (26 examples) can be accessed in an overall good yield and excellent selectivity (up to 97 % yield, generally >99 : 1 ketone:aldehyde ratio). Stereochemical analysis of the reaction sequence reveals migration aptitudes in line with related 1,2‐shifts. By introducing a pyox ligand to palladium, prochiral methylenecyclobutanes can be desymmetrized, thus realizing the first enantioselective Wacker oxidation.
Fast chromatography of pulse triacylglycerols
Authors: Byrdwell William Craig , Kotapati Hari Kiran , Goldschmidt Robert 
Published: November 2022

AbstractA short 10‐min ultra high performance liquid chromatography (UHPLC) method was used for separation and lipidomic analysis of triacylglycerols (TAGs) in 10 pulses: baby lima beans, black beans, black‐eyed peas, butter beans, cranberry beans, garbanzo beans, green split peas, lentils, navy beans, and pinto beans. The lipids extracted using chloroform/methanol averaged 1.9–2.7% across all pulses except garbanzo beans, which gave 6.2% lipids. TAGs were analyzed using dual parallel mass spectrometry (LC1MS2), areas were integrated using LipidSearch 4.2 software, and percent relative TAG compositions were calculated. Fatty acid response factors were calculated by comparison to calibrated GC‐FID, which were used to calculate response‐factor adjusted TAG compositions. Principal component analysis revealed that the pulses separated into three clusters, which were further highlighted using hierarchical cluster analysis. A subset of TAGs was quantified using calibration curves made from alternating sets of regioisomers in the non‐linear high concentration range (~2.5 nMol/ml to ~300 nMol/ml). A linear calibration curve for the sum of tocopherols detected by fluorescence was constructed with a coefficient of determination, r2, >0.99 for low concentrations (0.50–50 μg/ml), but tocopherols in pulses appeared to be inefficiently extracted. TAG regioisomers were quantified based on a Critical Ratio (CR), [AA]+/[AB]+, interpolated between the CRs of two pure regioisomer standards taken from alternating calibration standards. TAG mole percent relative compositions are reported for the first time for most pulses and the compositions are given with more detail and specificity than previously reported.
Corrosion protection of stainless steel by a new and low‐cost organic coating obtained from cashew nutshell liquid
Authors: Nunes Maelson Sousa , Bandeira Rafael Marinho , Figueiredo Francisco Cardoso , dos Santos Junior José Ribeiro , de Matos José Milton Elias 
Published: November 2022

AbstractIn this work, the corrosion protection of 316L steel was promoted by an electro‐synthesized polymer obtained from the technical cashew nutshell liquid (t‐CNSL). Spectroscopic techniques confirmed the polymer formation. The polymer was dispersed in the ethyl acetate solvent and used to form coatings on 316L steel substrates. The coated samples were subjected to electrochemical tests in a saline environment. The coated electrode with poly(t‐CNSL) polymer was exposed to the corrosive medium for 24 days, and superior corrosion protection was observed compared with the uncoated sample. The open circuit potential measurements showed that the coated sample possessed a more positive corrosion potential when compared with the uncoated substrate. The electrochemical impedance spectroscopy results indicated that the coated electrode's polarization resistance (Rp) recorded ~1.0 MΩ cm2 after 24 days of exposure. A decrease in polarization resistance was observed with the exposure time due to the presence of micropores in the t‐CNSL coating. The polarization curves exhibited that the coated electrode with poly(t‐CNSL) has lower corrosion current density and less negative corrosion potential than the uncoated steel electrode. Therefore, t‐CNSL favors the manufacture of thin poly(t‐CNSL) coatings for corrosion protection purposes besides being a low‐cost material.
Substrate‐directed Synthesis of Isocoumarin and 3‐Ylidenephthalide Conjugated Noscapinoids and their Antiproliferative Activities
Authors: Kumar Pedapati Ravi , Chirra Nagaraju , Pranathi Abburi Naga , Bollikonda Rakesh , Alekhya Danaboiena , Sridhar Balasubramanian , Naik Pradeep K. , Kantevari Srinivas 
Published: November 2022

AbstractA series of new noscapinoids designed; synthesized and assessed whether its 3‐ylidenephthalide and isocoumarin conjugates improved cytotoxicity. Cu‐catalysed Sonogashira coupling of N‐propargyl noscapine with 2‐bromobenzoic acids followed by in‐situ substrate‐directed 5‐exo‐dig or 6‐endo‐dig cyclization produced 3‐ylidenephthalide 6 a–6 f and isocoumarin 7 a–7 h analogues in very good yields. In comparison to the lead drug, noscapine, all the newly synthesised derivatives exhibited strong cytotoxic potential in vitro with IC50 ranging from 5.4 μM to 39.5 μM across the evaluated panel of cancer cell lines, without harming normal cells (IC50 >300 μM).
1H‐NMR Metabolomics Profiling and Volatile Content of ‘Hoja Santa’ (Piper auritum Kunth): A Millenary Edible Plant Consumed in Mexico
Authors: Pacheco‐Hernández Yesenia , Villa‐Ruano Nemesio , Cruz‐Duran Ramiro , Becerra‐Martínez Elvia , Lozoya‐Gloria Edmundo 
Published: November 2022

AbstractThe leaves of Piper auritum Kunth (‘Hoja Santa’) have been consumed for centuries by native people of central and southern Mexico as a fresh vegetable or condiment. Herein we present the result of the 1H‐NMR metabolomics profiling of three accessions of P. auritum harvested in three different provinces of Mexico (Puebla, Tlaxcala, and Oaxaca). The volatile content associated with the flavoring properties of the plant was also determined by GC/MS. The non‐targeted metabolome of these samples revealed that P. auritum is a source of free essential amino acids such as isoleucine, leucine, threonine, valine, histidine, phenylalanine, and tryptophan as well as organic acids, free monosaccharides, and valuable nutraceuticals such as trigonelline, Myo‐inositol, betaine, and choline. Principal component analysis and orthogonal partial least squares discriminated analysis of the metabolites found in P. auritum revealed trigonelline as the main differential compound found in the three studied accessions, suggesting this metabolite as a possible chemical marker. According to these statistical approaches, 60 % of the differential metabolites were provided by Oaxaca samples, suggesting that leaves harvested in this province have better (p<0.05) nutritional properties than the other samples analyzed. Nevertheless, the high abundance of the anti‐nutrient safrole (90 %) in the volatile fraction, advises the potential toxicity of P. auritum consumed in Oaxaca. On the other hand, samples harvested in the northern highlands of Puebla, contained the lowest levels of safrole (30 %) and acceptable levels of nutrients and nutraceuticals including choline. From the three groups of studied plants, those harvested in the northern highlands from Puebla, could be considered safer for human consumption than the other analyzed accessions.