bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal immunisation against Group B Streptococcus: a global analysis of health impact and cost-effectiveness
Authors: Procter Simon R. , Gonçalves Bronner P. , Paul Proma , Chandna Jaya , Seedat Farah , Koukounari Artemis , Hutubessy Raymond , Trotter Caroline , Lawn Joy E , Jit Mark 
Published: July 2022

AbstractBackgroundGroup B Streptococcus (GBS) can cause invasive disease (iGBS) in young infants, typically presenting as sepsis or meningitis, and is also associated with stillbirth and preterm birth. GBS vaccines are under development, but their potential health impact and cost-effectiveness have not been assessed globally.MethodsWe assessed the health impact and value (using net monetary benefit, NMB, which measures both health and economic effects of vaccination into monetary units), of GBS maternal vaccination across 183 countries in 2020. Our analysis uses a decision-tree model, combining risks of GBS-related outcomes from a Bayesian disease burden model with estimates of GBS related costs and Quality-Adjusted Life Years (QALYs) lost. We assumed 80% vaccine efficacy against iGBS and stillbirth, following the WHO Preferred Product Characteristics, and coverage based on the proportion of pregnant women receiving at least four antenatal visits. One dose was assumed to cost $50 in high-income countries, $15 in upper-middle income countries, and $3.50 in low-/lower-middle income countries. We estimated NMB using alternative normative assumptions that may be adopted by policy makers.FindingsVaccinating pregnant women could avert 214,000 (95% uncertainty range 151,000 – 457,000) infant iGBS cases, 31,000 deaths (14,000 – 67,000), 21,000 (9,000 – 52,000) cases of neurodevelopmental impairment, and 23,000 (10,000 – 58,000) stillbirths. A vaccine effective against GBS-associated prematurity might also avert 172,000 (13,000 – 378,000) preterm births. Globally, a 1-dose vaccine programme could cost $1.7 billion but save $385 million in healthcare costs. Estimated global NMB ranged from $1.1 billion ($-0.2 – 3.8 billion) to $17 billion ($9.1 – 31 billion).InterpretationMaternal GBS vaccination could have a large impact on infant morbidity and mortality globally and at reasonable prices is likely to be cost-effective.
Tuberculosis knowledge gaps and associated factors among suspects of tuberculosis in a peripheral emerging region of northwest Ethiopia: a case of Benishangul Gumuz
Authors: Lobie Tekle Airgecho , Roba Aklilu Abrham 
Published: July 2022

AbstractGood Knowledge about tuberculosis (TB) is a key element to have a favourable attitude and practice in the control of TB. However, in the resources limited peripheral emerging region of Ethiopia, there is a limited knowledge about it. Therefore, this study aimed to investigate the knowledge about TB symptoms, transmission, and prevention methods and identify the associated factors in Northwest Ethiopia.MethodsA facility-based cross-sectional study was conducted among 391 TB suspects in two hospitals and seven health centres in the Benishangul Gumuz region. Composite scales were generated for knowledge about TB symptoms, route of transmission, and prevention methods. Data were analysed by Statistical Package for Social Sciences (SPSS) Version 25. Multivariate logistic regression was conducted to identify associated factors. A P-value less than 0.05 was considered statistically significant.ResultsFrom a total of 391 approached TB suspects, 383 (98%) participated in the study with the mean age of 33.34 ±14.10 years ranging from 11-89 years. There was very poor knowledge about TB symptoms (12%) but fair knowledge about TB transmission (61.6%), and prevention (57.4%). The previous history of treatment was significantly associated with the participants’ overall poor knowledge about TB symptoms (AOR 2.787, 95% CI=1.148-6.765), route of transmission (AOR=4.03, 95% CI=1.82-8.92), and prevention methods (AOR=4.89, 95% CI=2.18-10.99). Also, being illiterate was associated with poor knowledge about the route of TB transmission (AOR 11.39, 95% CI 2.15 - 60.33) prevention methods (AOR 13.28, 95% CI 2.69-65.73).ConclusionThere was little knowledge about TB symptoms while fair knowledge about the mode of transmission and means of prevention in the Benishangul Gumuz region. Health education intervention particularly targeting TB symptoms, transmission, and prevention methods should be initiated through easily accessible media supported by effective strategies.
COVID-19 Vaccination Uptake and Self-Reported Side Effects among Healthcare Workers in Mbale City Eastern Uganda
Authors: Akech Gabriel Madut , Kanyike Andrew Marvin , Nassozi Ashah Galabuzi , Aguti Beatrice , Nakawuki Ashley Winfred , Kimbugwe Denis , Kiggundu Josen , Maiteki Robert , Mukyala Dorothy , Bongomin Felix , Obakiro Samuel Baker , Rebecca Nekaka , Iramiot Jacob Stanley 
Published: July 2022

ABSTRACTBackgroundFear of anticipated side effects has hindered the COVID-19 vaccination program globally. We report the uptake and the self-reported side effects (SEs) of the COVID-19 vaccine among Healthcare workers (HCWs) in Mbale City Eastern Uganda.MethodsA cross-sectional survey of HCWs at seven different level health facilities was conducted from 6th September to 7th October 2021 using a structured self-administered questionnaire.ResultsCOVID-19 vaccine had been received by 119 (69%) participants of which 79 (66%) received the two recommended doses of the AstraZeneca vaccine. Getting vaccinated was associated with working in a lower health facility (aOR= 14.1, 95% CI: 4.9 – 39.6, P=0.000), perceived minor risk of contracting COVID-19 (aOR= 12.3, 95% CI: 1.0 – 44.6, p=0.047), and agreeing that COVID-19 vaccine is protective (aOR= 16.7, 95% CI: 5.6 – 50.4, p=0.000). 97 (82%) of participants experienced side effects to at least one dose of which most were mild on both the first (n=362, 51%) and second dose (n=135, 69%). The most frequently reported side effects on the first and second dose were fever (79% and 20%), injection site pain (71% and 25%), and Fatigue (69% and 20%) respectively.ConclusionsThe majority of the HCWs in Mbale City had received at least one dose of the COVID-19 vaccine and experienced a side effect. The side effects were mostly mild on either dose thus the vaccines are generally safe.
High-Intensity Interval Training Improves physical morphology, Cardiopulmonary Fitness and Metabolic Risk Indicators of Cardiovascular Disease in Children and Adolescents: A Systematic Review and Meta-Analysis
Authors: Menjie  , Shuangling Zou , Majia  , chenmin Xiang , Shufeng Li , Junli Wang 
Published: July 2022

ABSTRACTObjectiveTo systematically evaluate the safety and efficacy of high-intensity interval training in children and adolescents.DesignSystematic Review and Meta-AnalysisMethodsEight databases were searched. Descriptive analysis of the efficacy and safety of high-intensity interval training on body shape, cardiorespiratory fitness, and metabolic risk markers for cardiovascular disease between children and adolescents. Subgroup analysis was performed with age, participants, intervention time, and exercise frequency as covariates.Results47 studies included 2995 children and adolescents. Meta-analysis results showed that high-intensity interval training significantly improved cardiorespiratory fitness indicators (VO2max, SBP, DBP and HRmax) and cardiovascular disease metabolic risk indicators (TC, HDL-C). HIIT had no significant effect on body shape indicators (BMI, BF% and WC) and some cardiometabolic indicators (TG and LDL-C).ConclusionCurrent evidence shows insufficient evidence that high-intensity interval training with intermittent running as the main form of exercise improves body shape indicators in children and adolescents. Nevertheless, it deserves to recommend for the purpose of improving cardiorespiratory fitness and reducing the metabolic risk of cardiovascular disease.
Structural basis of human PRPS2 filaments
Authors: Lu Guangming , Hu Huan-Huan , Chang Chia-Chun , Zhong Jiale , Zhou Xian , Guo Chen-Jun , Zhang Tianyi , Li Yi-Lan , Yin Boqi , Liu Ji-Long 
Published: July 2022

ABSTRACTPRPP synthase (PRPS) transfers the pyrophosphate groups from ATP to ribose-5-phosphate to produce 5-phosphate ribose-1-pyrophosphate (PRPP), a key intermediate in the biosynthesis of several metabolites including nucleotides, dinucleotides and some amino acids. There are three PRPS isoforms encoded in human genome. While hPRPS1 and hPRPS2 are expressed in most tissues, hPRPS3 is exclusively expressed in testis. Although hPRPS1 and hPRPS2 share 95% sequence identity, hPRPS2 has been shown to be less sensitive to allosteric inhibition and specifically upregulated in certain cancers in the translational level. Recent studies demonstrate that PRPS can form a subcellular compartment termed the cytoophidium in multiple organisms across prokaryotes and eukaryotes. Forming the cytoophidium is considered as a distinctive mechanism involving the polymerization of the protein. In order to investigate the function and molecular mechanism of hPRPS2 polymerization, we solve the polymer structure of hPRPS2 at 3.08Å resolution using cryo-Electron Microscopy (cryo-EM). hPRPS2 hexamers stack into polymers in the conditions with the allosteric/competitive inhibitor ADP. The binding modes of ADP at the canonical allosteric site and at the catalytic active site are clearly determined. A point mutation disrupting the inter-hexamer interaction prevents hPRPS2 polymerization and results in significantly reduced catalytic activity. Our findings suggest that the regulation of hPRPS2 polymer is distinct from E. coli PRPS polymer and provide new insights to the regulation of hPRPS2 with structural basis.
Mismatch resolution for repeat-mediated deletions show a polarity that is mediated by MLH1
Authors: Trost Hannah , Merkell Arianna , Lopezcolorado Felicia Wednesday , Stark Jeremy M. 
Published: July 2022

ABSTRACTRepeat-mediated deletions (RMDs) are a type of chromosomal rearrangement between two homologous sequences that causes loss of the sequence between the repeats, along with one of the repeats. Sequence divergence between repeats suppresses RMDs; the mechanisms of such suppression and of resolution of the mismatched bases remains poorly understood. We identified RMD regulators using a set of reporter assays in mouse cells that test two key parameters: repeat sequence divergence and the distances between one repeat and the initiating chromosomal double-strand break. We found that the mismatch repair factor MLH1 suppresses RMDs with sequence divergence in a manner that is epistatic with the mismatch repair factors MSH2 and MSH6, and which is dependent on residues in MLH1 and its binding partner PMS2 that are important for nuclease activity. Additionally, we found that resolution of mismatches in the RMD product have a specific polarity, where mismatched bases that are proximal to the chromosomal break end are preferentially removed. Moreover, we found that the MLH1 endonuclease domain is important for this polarity of mismatch resolution. Finally, we identified distinctions between MLH1 vs. TOP3α in regulation of RMDs. We suggest that MLH1 suppresses RMDs with sequence divergence, while also promoting directional mismatch resolution.
Dengue seroprevalence study during COVID-19 pandemic in Bali
Authors: Masyeni Sri , Fatawy Rois Muqsith , Paramasatiari AAAL , Maheraditya Ananda , Dewi Ratna Kartika , Winianti NW , Santosa Agus , Setiabudy Marta , Sumadewi Nyoman Trisna , Herawati Sianny 
Published: July 2022

AbstractIntroductionDengue infection poses significant public health problems in tropical and subtropical regions all over the world. The clinical manifestation of dengue varies from asymptomatic cases to severe dengue manifestation. The detection of clinical cases enables us to measure the incidence of dengue infection, whereas serological surveys give insights into the prevalence of infection. This study aimed to determine the dengue prevalence among healthy adult patients in Bali.MethodCross-sectional seroprevalence surveys were performed from July 2020 to June 2021 among healthy and adult patients in Denpasar Bali. Blood samples were collected from 539 randomly selected samples from urban sites in Denpasar. IgG antibodies against DENV were detected in serum using a commercial enzyme-linked immunosorbent assay (ELISA) kit.ResultsOverall, the positive dengue seroprevalence rate among 539 clinically healthy adult patients was high (85.5%). The subject’s median age was 34.1 (range between 18-86.1) years old. Most participants in the study were younger than 40 years old (61.2%). The gender is dominated by males (54.5%). The study found a significant association of dengue seropositivity among people age more than 40 years old with healthy status (p=0.005 and p<0.001, respectively). Another seroprevalence study reported a lower rate of dengue infection in children in Indonesia (69.4%). The difference may be associated with less probability of Aedes bites among the children. The study reflected the proportion of asymptomatic dengue that needs better assessment with a serological test.ConclusionThe current study highlighted a high prevalence of dengue seropositive with a relatively dominant proportion of asymptomatic cases. The study guides the physicians o to beware of every dengue infection in tropical countries and prevents the spread of the disease.
Spillover and crossover effects of social support through work-family balance: a time-lagged analysis in Italian dyads
Authors: Lo Presti Alessandro , Van der Heijden Beatrice , Landolfi Alfonso 
Published: July 2022

PurposeBuilding on the spillover-crossover model (Bakker and Demerouti, 2013), this study aimed to examine the processes through which three forms of social support at work (i.e. from coworkers, from supervisor and organizational family-friendly) were positively associated with an individual's level of work-family balance (spillover effect), and through this latter, with one's partner's family life satisfaction (crossover effect), via the partner's perception of family social support as provided by the incumbent person.Design/methodology/approachThe authors sampled 369 heterosexual couples using a time-lagged design, surveying forms of social support at work and work-family balance at t1 and family social support and partner's family life satisfaction at t2. Data were analyzed through structural equation modeling.FindingsThe results showed that coworkers’ support and organizational family-friendly support positively predicted work-family balance. Furthermore, work-family balance mediated the associations between organizational family-friendly support and coworkers’ support with instrumental family social support. Moreover, only emotional family social support positively predicted partner's family life satisfaction.Originality/valueThe authors simultaneously examined the direct and indirect associations of three concurrent forms of social support at work with one's work-family balance (spillover effect). Moreover, in line with the spillover-crossover model, the authors adopted a systemic approach and assessed how one's work-family balance is associated with emotional and instrumental family social support as perceived by one's partner and the latter's family life satisfaction (crossover effect).
Challenges to developing smart prisons in the United Arab Emirates
Authors: Aldhaheri Mohammed Abdulla , Xia Bo 
Published: July 2022

Purpose
The smart building concept has gained prominence in the construction sector during the past decade. In the United Arab Emirates, although smart building technology has been widely adopted in different building sectors, no empirical studies have examined the applicability of the smart buildings concept in prison facilities. The current study aims to understand the current status of prison buildings in the UAE and the challenges faced by the prison industry to implement new smart technology.

Design/methodology/approach
This study involved a semi-structured interview consisting of 14 participants who were interviewed face-to-face about their opinion about the objectives of the study. The interviewees were experts from the prison and construction industry of the UAE working at the top management level. Mind-maps were created from the thematic data using Nvivo software.

Findings
The results demonstrated that among current issues prevailing in prisons, overcrowding was regarded as the most severe issue. Additionally, in most cases, there is no systemic classification of inmates. Concerning the potential challenges in the implementation of smart technologies in the prison buildings, being too old and outdated of prison buildings are a significant concern, followed by a substantial gap in the approval system of budget to purchase new smart technology.

Originality/value
The findings of this study are of vital importance and help to identify potential challenges involved in the implementation of smart technologies in prison buildings that should be taken into consideration before selecting any new smart technology.
The costs of introducing a vaccine in sub-Saharan Africa: a systematic review of the literature
Authors: De Micco Patrice , Maraghini Maria Pia , Spadafina Tiziana 
Published: July 2022

PurposeThis study provides a systematic literature review and categorization of the costs reported in the literature for the introduction of new vaccines, focusing on sub-Saharan Africa within LMICs, where vaccines are highly needed, financial resources are scarce and data are lacking and scattered.Design/methodology/approachA systematic literature search of PubMed and Web of Science databases was conducted according to the PRISMA requirements. Searches also included the relevant grey literature. In total, 39 studies were selected and nine cost categories were investigated to build a comprehensive framework.FindingsThe paper considers nine cost categories that cover the whole life of the vaccine, from its initial study to its full implementation, including for each of them the relevant subcategories. The systematic review, besides providing specific quantitative data and allowing to assess their variability within each category, points out that delivery, program preparation, administration and procurement costs are the most frequently estimated categories, while the cost of the good sold, costs borne by households and costs associated to AEFI are usually overlooked. Data reported on R&D costs and investment in the production plant differ significantly among the selected contributions.Originality/valueThe literature contributions on cost estimation tend to focus on a precise vaccine, a specific geographic area, or to adopt a narrow approach that captures only a subset of the costs. This article presents a rich and inclusive set of the economic quantitative data on immunization costs in limited-resource countries.
Federated learning algorithm based on matrix mapping for data privacy over edge computing
Authors: Tripathy Pradyumna Kumar , Shrivastava Anurag , Agarwal Varsha , Shah Devangkumar Umakant , L. Chandra Sekhar Reddy , Akilandeeswari S.V. 
Published: July 2022

Purpose
This paper aims to provide the security and privacy for Byzantine clients from different types of attacks.

Design/methodology/approach
In this paper, the authors use Federated Learning Algorithm Based On Matrix Mapping For Data Privacy over Edge Computing.

Findings
By using Softmax layer probability distribution for model byzantine tolerance can be increased from 40% to 45% in the blocking-convergence attack, and the edge backdoor attack can be stopped.

Originality/value
By using Softmax layer probability distribution for model the results of the tests, the aggregation method can protect at least 30% of Byzantine clients.
Exploring the role of external pressure, environmental sustainability commitment, engagement, alliance and circular supply chain capability in circular economy performance
Authors: Agyabeng-Mensah Yaw , Afum Ebenezer , Baah Charles , Essel Dacosta 
Published: July 2022

PurposeThis study explores the role of external pressure, engagement capability (ENC), alliance capability (ACA), environmental sustainability commitment (ESC), and circular supply chain capability in circular economy performance.Design/methodology/approachThrough a cross-sectional survey and data collected from 124 small and medium enterprises (SMEs) in Ghana, this study employs partial least square structural equation modelling (PLS-SEM) to test the proposed model.FindingsThe findings reveal the following; first, external pressure has a significant impact on ESC. Second, ESC positively impacts ACA, ENC and circular supply chain capability. Third, ACA and ENC mediate the relationship between ESC and circular supply chain capability. Finally, circular supply chain capability has a significant impact on circular economy performance.Originality/valueThe originality of this study lies in testing a novel model that confirms that SMEs respond to external pressure by enhancing ESC as well as develop engagement and alliance capabilities to improve circular supply chain capability to achieve circular economy performance goals.
Mitigating implicit racial bias in tipping: when direct and indirect experience matters
Authors: O’Rourke Anne-Maree , Belli Alex , Mathmann Frank 
Published: July 2022

Purpose
Academic research has supported the belief that consumers undertip minority race service workers due to implicit racial biases. However, there has been less focus in examining possible moderating factors. This paper aims to fill this gap by analyzing the role of direct and indirect experience in tipping frontline service workers from a minority background. Given the prominence of customer ratings on digital service platforms and the perception that African Americans are discriminated against, the authors look at the interplay of interaction length (direct experience) and customer ratings (indirect experience) on the relationship between race and tipping.

Design/methodology/approach
An expectancy disconfirmation framework was developed and tested with a sample of 360 US participants in an online experiment. The experiment followed a 2 × (race: African-American versus Caucasian) × 2 (direct experience: limited versus extensive) × 3 (indirect experience: absent versus positive versus negative customer rating) design.

Findings
The authors found consumers who have extended direct experience (longer service interaction) and no indirect experience (absent customer ratings) tipped African Americans more than Caucasians. Interestingly, this effect is reduced in the presence of indirect experience (customer ratings). Finally, where the consumer lacks direct experience (shorter service interaction) but is exposed to positive indirect experience (positive customer ratings), consumers tip African Americans more.

Originality/value
To the best of the authors’ knowledge, this is the first paper that examines the role of direct and indirect experience in the relationship between race and tipping. Based on the authors’ findings, the authors provide several contributions, including recommendations to reduce inequalities arising from implicit racial bias on digital service platforms.