bluuebunny/crossref_metadata_2025_split huggingface dataset:
The comorbidities of psoriasis and the effects of long-term exposure to air pollution on psoriasis: an urban population–based retrospective cohort study
Authors: Seo Hyun-Min , Park Se Kwang , Kim Sungyu , Park Ji Hun , Oh Se Uk , Kim Joung Soo 
Published: July 2022

Abstract
Background: To date, the relationship between air pollutants and psoriasis is not well establishedObjective: This study aimed to evaluate the effects of long-term exposure to air pollution on psoriasis.Methods: Using the Korean National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) database, incident cases of psoriasis were calculated from 2008–2015. We collected daily air pollutants from AIRKOREA and the Air Quality Analysis and Control Center in Seoul and climatological variables from the Korean Meteorological Administration.Results: Between 2008–2015, there were 1,502 incident cases with psoriasis among an urban population of 105,800 people. Ischemic heart disease and diabetes as comorbidities were significantly more common in subjects with psoriasis compared to those without psoriasis. After adjusting for age, sex, income, comorbidities, and meteorological variables, long-term exposure to air pollutants, including particulate matter <2.5 μm in diameter (hazard ratio [HR], 1.651; for 1 μg/m3), particulate matter <10 μm in diameter (HR, 1.301; for 1 μg/m3), sulfur dioxide (HR, 4.109; for 1 part per billion [ppb]), nitrogen dioxide (HR, 1.683; for 1 ppb), and carbon monoxide (HR, 1.330; for 1 ppb), were significantly associated with increased risk for developing psoriasis.Limitations: The NHIS-HEALS database lacks detailed information on individual subjects. Conclusions: This study suggests that exposure to PM2.5, PM10, SO2, NO2, and CO independently increases the risk of developing psoriasis. Further studies are needed to investigate the mechanisms involved in the role of air pollutants in psoriasis onset.
Category-Aware Deep Multimodal Network with Hybrid Attention Mechanism for Fashion Compatibility Modeling
Authors: Li Yun , Zhang jing , Li Guoxiang , jing peiguang , wang xuejun 
Published: July 2022

Abstract
To address the problem of alignment representation and compatibility prediction in the multimodal feature fusion of fashion items, this paper designs a fashion compatibility prediction model based on a deep attention mechanism and category perception. The model comprises an attention mechanism fusion module and a category-aware module. The former is a fusion model based on the transformer cross-modal attention mechanism, which aligns visual features and text features for feature dimensionality and semantics. To utilize the category information of single products, the potential space of category embedding is constructed for different category pairings based on coarse-grained category partitioning pairs to build different mapping networks, and the compatibility scores between single products are calculated. The experimental simulation results show that compared with existing methods, the accuracy of clothing collocation and the accuracy of the fill-in-the-blank task on the publicly available Polyvore and Polyvore-D datasets are improved.
Screening key marker molecules of osteosarcoma using bioinformatics analysis technology
Authors: Xu Ruiqing , Wan Ningjun , Shi Jiandang 
Published: July 2022

Abstract
BACKGROUND: The most frequent primary bone tumor in children, adults, and elderly individuals over 60 years of age is osteosarcoma (OS), which is most commonly detected in the long bone epiphysis and has a poor prognosis and a high impairment rate. The precise etiology and underlying molecular pathways, however, remain unknown. Using bioinformatics approaches to evaluate the underlying biological mechanisms, this work attempted to discover differentially expressed genes (DEGs) in OS, implicated cell signaling pathways, and associated immune infiltration.MATERIALS AND METHODS: The GSE14359 dataset's expression profiles were downloaded from the GEO database, which contains 20 samples, including 18 OS samples and 2 normal osteoblast control samples. Raw data were collected, DEGs were obtained, and bioinformatics was used to further analyze the data. The gene expression matrix was subjected to WGCNA-weighted gene co-expression network analysis using R (version 4.1.1) software, as well as gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of candidate genes. The STRING database was used to create protein-protein interaction (PPI) networks of candidate genes. Core gene network maps were created using the Cytoscape software. The R (version 4.1.1) software was used to rank key genes. Subsequently, plots of individual hub gene survival curves, expression and clinical correlation and promoter methylation and clinical correlation were produced via an online website (http://ualcan.path.uab.edu/). Finally, the infiltration of immune cells in OS was assessed using CIBERSORT.RESULTS: A total of 625 DEGs were identified, of which 314 were up-regulated and 311 were down-regulated. Principal component analysis showed significant differences between the two tissues. WGCNA-weighted gene co-expression showed the highest absolute value of the MEgrey60 module, and a total of 247 genes were listed in the intersection of DEGs and MEgrey60 module genes taken.KEGG pathway analysis showed that these candidate genes mainly involved adherent spots, Rap1, PI3K-Akt, and MAPK, while GO pathway analysis mainly involved cellular processes such as osteogenesis, epithelial cell proliferation, osteoblast differentiation, and molecular functions such as growth factors and fibronectin binding. The 23 most closely related genes among the candidate genes were identified from the PPI network.CONCLUSION: Our study shows that screening for DEGs, pathway enrichment and immune infiltration using bioinformatics analysis not only helps to understand the molecular mechanisms of OS occurrence but also facilitates us to better execute target gene interventions. However, this study still has limitations and subsequent clinical validation of the samples is needed.
Role of Procalcitonin in the Timely Detection of Ischemia and Necrosis in Children With Intestinal Obstruction
Authors: Dominguez-Muñoz Alfredo , Davila-Perez Roberto , Fernandez-Portilla Emilio , Parra-Ortega Israel , Reyes-Lopez Alfonso , Bracho-Blanchet Eduardo 
Published: July 2022

Abstract
Introduction: Procalcitonin (PCT) has been studied for early identification of ischemia and/or necrosis (I/N) in children with intestinal obstruction (IO) secondary to adhesive small bowel obstruction (ASBO). However, the causes of IO in children are numerous. Purpose: To correlate the level of PCT with the presence of I/N.Results: Fifty-seven patients were analyzed. The incidence of I/N was 36%. PCT median was statistically higher in patients with I/N compared to those patients with normal intestine: 4.13 (13.9) vs 0.11 (0.28) ng/ml, p = <0.001. A PCT threshold >1.17 ng/ml for predicting I/N yielded a sensitivity of 90%, a specificity of 97%, a positive predictive value (PPV) of 95%, a negative predictive value (NPV) of 94%, p = <0.001, relative risk (RR) 17.57 (95%CI, 4.54 – 67.90). Similarly, a PCT threshold >1.41 ng/ml for predicting intestinal necrosis yielded a sensitivity of 92%, a specificity of 88%, a PPV of 72%, a NPV of 97%, p = <0.001, RR 28.16 (95%CI, 3.98 – 119.12).Conclusions: This study corroborates the association of PCT with IN in children with IO and expands the evidence of its use in this field. Similarly, suggests a PCT threshold >1.17 ng/ml and >1.41 for predicting IN and intestinal necrosis respectively.
Breast Conservation Therapy Decreased Heart-specific Mortality in Breast Cancer patients Compared with Mastectomy
Authors: Li Zhi , Zhao Ruipeng 
Published: July 2022

Abstract
Aim: To investigate the impacts of breast conservation therapy (BCT) and mastectomy on heart-specific mortality in breast cancer patients.Methods: Patients with primary breast cancer registered in the Surveillance, Epidemiology, and End Results (SEER) database between Jan 1998 and Dec 2015 were included. Patients were divided into either breast conservation therapy or mastectomy group. To compare mortality caused by heart diseases in breast cancer patients with BCT or mastectomy, univariate and multivariate regression after propensity score matching (PSM) were performed. Kaplan-Meier analysis was also used to evaluate heart-specific survival between two groups. Results: 132,616 patients with breast cancer were enrolled in this study. After PSM, four risk factors including age, race, marital status and types of surgery were identified significantly associated with death from heart diseases. Heart-specific survival analysis further showed that overall, BCT poses a lower risk to heart-specific mortality compared with mastectomy. Conclusion: Compared with mastectomy, BCT significantly decreased heart-specific mortality in breast cancer patients.
SOX9+ malignant cells define a poor prognosis subtype of Glioma with tumor-associated macrophage recruitment
Authors: Yu Shizhe , Ma Chao , Wang Haoren , Yu Bin , Luan Yi , Xia Zongping 
Published: July 2022

Abstract
Background
Gliomas, as the most common aggressive type of primary brain tumors, are highly prevalent and incurable among adults. The dysregulation of transcription factors, including sex determining region Y (SRY)-related high-mobility group (HMG) box (SOX) genes, are considered to be important in cancer development and progression. The aim of our study was to evaluate the effect of SOX9 in the prognosis of glioma.
Results
We revealed aberrant regulation of most SOX family genes by using 1289 glioma samples from the Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) cohorts. We identified 4 critical genes, SOX3, SOX6, SOX8 and SOX9, -based risk signature model through LASSO regression and a specific SOX9 + cell state with more pronounced malignancy through high-quality single-cell RNA sequencing data analysis. The up regulation of SOX9 and the downregulation of SOX3, SOX6, and SOX8 indicate a decrease in overall survival. The SOX9 + cell state represents a greater proliferative capacity and invasive metastatic properties and is a primary source of attraction for infiltration of bone marrow-derived myeloid (BMM) cells, which are also demonstrated by multicolor immunofluorescence analysis.
Conclusions
Our study suggests that SOX9 is an independent prognostic and predictive factor for glioma, and the potential interaction between SOX9 + malignant cells and BMM deserves further investigation.
Perinatal presentations of nonimmune hydrops fetalis due to biallelic pathogenic variants in PIEZO1: underdiagnosed?
Authors: Beneteau Claire , ghesh leïla , Désir Julie , Haye Damien , tanno pauline le , Devillard Françoise , Cogné Benjamin , marangoni martina , tecco laura , Héron Delphine , vaillant claudine le , Joubert Madelein 
Published: July 2022

Abstract
Hydrops fetalis is a rare disorder associated with significant perinatal complications and a high perinatal mortality of at least 50%. Nonimmune hydrops fetalis (NIHF) is more frequent and results from a wide variety of etiologies. One cause of NIHF is lymphatic malformation 6 (LMPHM6 or generalized lymphatic dysplasia of Fotiou) due to biallelic loss-of-function (LoF) variants in PIEZO1. Most individuals are diagnosed postnatally and only few clinical data are available on fetal presentations. We report six novel biallelic predicted LoF variants in PIEZO1 identified by exome sequencing in six fetuses and one deceased neonate from four unrelated families affected with LMPHM6: three nonsense variants (NM_001142864.4: c.2604T > A, p.(Cys868*); c.7117C > T, p.(Gln2373*) and c.1965C > G, p.(Tyr655*)), two splice-site variants (c.4775 + 1G > A, c.365-1G > A) and one frameshift (c.6468_6469del, p.(Lys2157Glufs*63)). During the pregnancy, most cases are revealed by isolated NIHF at second trimester of gestation. At post-mortem examination ascites, pleural effusions and telengectasies can guide the etiological diagnosis. We aim to further describe the perinatal presentation of this condition which could be underdiagnosed.
Effect of Nanoclay on Combustion, Mechanical and Morphological Properties of Recycled High Density Polyethylene/Organomodified Montmorillonite/Marula Seed Cake Nanocomposites
Authors: Ogah Anselm Ogah , Ezeani Obumneme Emmanuel 
Published: July 2022

Abstract
The aim of the study was to investigate the suitability of using marula seed cake as filler in recycled polyethylene (R-HDPE) composite manufacturing. In response to the disposal of environmental problematic agricultural and plastic waste, 50:50 wt% of recycled high density polyethylene (R-HDPE)/marula seed cake (MSC) agro-waste filler with varying contents (0, 2, 4, and 6 phc) of organomodified montmorillonite (OMMT) were produced by melt compounding technology. The effects of OMMT on the combustion, mechanical and morphological properties of R-HDPE/MSC/OMMT nanocomposites were investigated. Characterization of composites was performed using cone calorimetry, universal testing machine and scanning electron microscopy. Results showed that tensile and flexural strength and moduli increased with increase in the OMMT content up to 2 phc and then decreased. The optimum tensile and flexural strength and modulus were found to be 45.48 and 4061.52MPa, 30.78 and 3069.38MPa for the composites filled with 2 phc OMMT. Morphological images revealed that samples with 2phc showed no evidence of OMMT aggregation, whereas samples with 4 and 6 phc showed aggregated OMMT which caused reduced mechanical strength. It was found that the OMMT effectively improved flame retardancy of HDPE/MSC/OMMT nanocomposites with increase in the limiting oxygen index (LOI) and remarkably prolonged time to ignition (TTI) and decreasing heat release rate (HRR), as well as strongly reducing mass loss rate (MLR) and burning rate (BR). It can be inferred that MSC content of up to 50wt% and 50wt% R-HDPE with 2 phc of OMMT optimum content could be used in composite production.
Protective role of Codiaeum variegatum against genotoxicity induced by carmustine in somatic and germ cells of male mice
Authors: Fahmy Maha A. , Farghaly Ayman A. , Hassan Entesar E. , Abd-Alla Howaida Ibrahim , Hassan Zeinab M. 
Published: July 2022

Abstract
Carmustine (Cr) is an important chemotherapeutic drug widely used in the treatment of brain tumors. Herein, the genotoxic side effect of Cr was evaluated by using different cytogenetic parameters. Also, the protective role of Codiaeum variegatum leaves ethyl acetate fraction at different doses was determined. The technique HPLC-qTOF-MS/MS was used to identify the constituents in C. variegatum. A total of 90 male mice was used to evaluate micronuclei (MPCEs) in bone marrow, chromosomal aberration (CAs) in the bone marrow and mouse spermatocytes, sperm abnormalities, and gene expression (qRT-PCR). The following groups were included, I: Control negative (ethanol 30%), II: Control positive (i.p injected once with 30 mg/kg Cr), III: Control plant orally treated with C. variegatum at 500 mg/kg, four days). IV-VI: treated with 100, 300, and 500 mg/kg of the plant (4 days) plus a single dose of Cr on the last day of treatment. The results revealed the genotoxic effect of Cr in somatic cells evidenced by increasing in MPCEs and CAs by 3 and 7- folds respectively over the corresponding control. Cr also induced a significant percentage of CAs in spermatocytes in meiosis in the form of univalent (X-Y and autosomal univalent) and also a significant percentage of morphological sperm abnormalities was recorded. A large number of coiled tail abnormalities were detected indicating the effect of Cr in sperm motility. Cr also induced an overexpression of the P53 gene. C. variegatum mitigated all deleterious genotoxic effects of Cr with a dose-related relationship. By using HPLC-qTOF-MS/MS analysis, it was found that flavones (35.21%), phenolic acids (17.62%), flavonols (3.40%), isoflavones (0.53%), constitute mainly the polyphenolic components of the leaves. Other important phytochemicals (8.29–0.49%) such as coumarins, indoles, fatty acids, and amino acids, were also identified. Such components together participate in the obtained protective role of C. variegatum.
Very low incidence of HIV-infection and decreasing incidence of sexually transmitted infections among PrEP users in 2020 after introduction of coverage by health insurance in Germany
Authors: Schmidt Daniel , Kollan Christian , Bartmeyer Barbara , Bremer Viviane , Schikowski Tim , Friebe Martin , Schellberg Sven , Scholten Stefan , Bickel Markus , Hanhoff Nikola , Rüsenberg Robin , Schewe Knud , group NEPOS study 
Published: July 2022

Abstract
IntroductionObjectives of this study, as part of a nation-wide HIV pre-exposure prophylaxis (PrEP) evaluation project, were to determine the incidence of infections with HIV, chlamydia, gonorrhea, syphilis, hepatitis A/B/C in persons using PrEP, and to describe the health care funded PrEP use in Germany. Additionally, factors associated with chlamydia/gonorrhea and syphilis infections were assessed.MethodsAnonymous data of PrEP users were collected at 47 HIV-specialty centers from 09/2019-12/2020. Incidence rates were calculated per 100 person years (py). Using longitudinal mixed models, we analyzed risk factors associated with sexually transmitted infections (STIs).Results4620 PrEP users were included: 99.2% male, median age 38 years (IQR 32-45), 98.6% men who have sex with men (MSM). The median duration of observation was 451 days (IQR 357-488), totaling 5132 py.Four HIV infections were diagnosed, incidence rate 0,078/100py (95% CI 0.029-0.208). For two suboptimal adherence was reported and in the third case suboptimal adherence and resistance to emtricitabine was observed. One infection was likely acquired before PrEP start.Incidence rates were 21.6/100py for chlamydia, 23.7/100py for gonorrhea, 10.1/100py for syphilis and 55.4/100py for any STI and decreased significantly during the observation period. 65.5% of syphilis, 55.6% of chlamydia and 50.1% of gonorrhea cases were detected by screening of asymptomatic individuals. In a multivariable analysis among MSM younger age, PrEP start before health insurance coverage and daily PrEP were associated with greater risk for chlamydia/gonorrhea. Symptom triggered testing and a history of STI were associated with a higher risk for chlamydia/gonorrhea and syphilis. A significantly lower risk for chlamydia/gonorrhea and syphilis was found for observations during the covid-19 pandemic period.ConclusionsWe found that HIV-PrEP is almost exclusively used by MSM in Germany. A very low incidence of HIV-infection and decreasing incidence rates of STIs were found in this cohort of PrEP users. The results were influenced by the SARS-CoV-2 pandemic. Rollout of PrEP covered by health insurance should be continued to prevent HIV infections. Increased PrEP availability to people at risk of HIV infection through the elimination of barriers requires further attention. Investigation and monitoring with a longer follow-up would be of value.
Boerhaave’s Syndrome: A Case Presentation
Authors: Saqr Mahmoud , Almasloot Ahmed , Eltawagny Mahmoud , Hawana Osama 
Published: July 2022

Abstract
BackgroundSpontaneous oesophagal rupture is a rare and non-common presentation which requires a high level of clinical suspicion. Case presentationA 39-y-old patient presented with atypical symptoms of severe abdominal pain, constipation, and vomiting. Abdominal pain resolved after initial treatment, thought to have acute abdominal pathology, initial chest X-ray & abdominal X-ray were normal studies with no identified acute pathologies. The patient was kept under observation till deterioration happened, a computed tomography scan (CT scan) was done for suspected intra-abdominal sepsis, and then images showed a ruptured oesophagus. Eventually, the patient was admitted for urgent surgical intervention. ConclusionsThis case report describes a rare Emergency Department (ED) presentation which requires a high index of suspicion, early diagnosis, and urgent management.
Symbiont Genotype Influences Holobiont Response to Increased Temperature
Authors: Moffat Jennica J. , Coffroth Mary Alice , Wallingford Piper D. , terHorst Casey P. 
Published: July 2022

Abstract
As coral reefs face warming oceans and increased coral bleaching, a whitening of the coral due to loss of microalgal endosymbionts, the possibility of evolutionary rescue offers some hope for reef persistence. In tightly linked mutualisms, evolutionary rescue may occur through evolution of one or both partners. Many obligate mutualisms are composed of relatively small, fast-growing symbionts with greater potential to evolve on ecologically relevant time scales than their relatively large, slower growing hosts. We examined the potential for adaptation of the upside-down sea jelly Cassiopea xamachana to increased temperature via evolution of its microalgal endosymbiont, Symbiodinium microadriaticum. We quantified trait variation among five algal genotypes in response to three temperatures and fitness of hosts infected with each genotype. All genotypes had positive growth rates at each temperature, but rates of respiration and photosynthesis decreased with increasing temperature. Responses varied among genotypes but were unrelated to genetic similarity. The effect of temperature on asexual reproduction and the timing of development in the host also depended on the genotype of the symbiont. Natural selection could favor different algal genotypes at different temperatures, affecting host fitness. This eco-evolutionary interaction may be a critical component of understanding species resilience in increasingly stressful environments.
A Comparative Analysis of ARIMA and other Statistical Techniques in Rainfall Forecasting: A Case Study in Kolkata (KMC), West Bengal
Authors: Alam Md Juber , Majumder Arijit 
Published: July 2022

Abstract
Rainfall forecasting in urban environments is an important concern for city planners since it is linked to urban water management. In this study, the ARIMA (auto-regressive integrated moving average) model, as well as several regression approaches such as simple linear and second to sixth-degree polynomial regression equations have been used to forecast the annual rainfall based on 120 years of monthly and annual rainfall from 1901 to 2020 in Kolkata Municipal Corporation (KMC), West Bengal. It is a comparison of ARIMA and other regression techniques for forecasting rainfall using r squared and root mean square error (RMSE). The ARIMA model has been implemented through machine language using the python platform and other regression equations have been computed and analyzed in Microsoft Excel 2019. For using ARIMA, all assumptions were tested and the best order of the model was determined using the import auto-Arima package from the pmdarima.arima library and the stepwise model.aic function, which produced 0,1,1 as the best order of the model. The result shows that among all the regression approaches used to forecast rainfall the fifth-degree polynomial equation has the lowest RMSE making it the best model to forecast rainfall in this analysis.