bluuebunny/crossref_metadata_2025_split huggingface dataset:
First psychotic episode as first manifestation of lyme disease: Case report
Authors: Leite R. Almeida , Almeida M. , Costa A. , Alcafache J. , Mesquita A. 
Published: February 2022

IntroductionLyme disease (LD) is caused by the spirochete Borrelia burgdorferi (Bb) and has been reported to be associated with various psychiatric presentations.ObjectivesTo report a case with LD and to highlight the importance of differential diagnosis in a first psychotic episode.MethodsCase report and non-systematic review of the literature.Results
A woman aged 31 was admitted to the psychiatric department, after a car accident with a mortal victim, due to a first psychotic episode with visual hallucinations, disorientation in time and space, persecutory and grandiosity delusions. She had a personal psychiatric history of obsessive-compulsive disorder and no previous admission to an inpatient Unit. On psychotropic drugs the condition failed to improve, and subsequently neurological symptoms developed. EEG abnormalities prompted a lumbar puncture. In the CSF a strong plasma cell reaction with atypical cells was observed. The enzyme immunoassay for Borrelia burgdorferi was positive and after treatment with penicillin the psychiatric and neurological signs and symptoms remitted. Screening assessment followed by a thorough history, comprehensive psychiatric clinical exam, review of systems, mental status exam, neurological exam and physical exam relevant to the patient’s complaints and findings with clinical judgment, pattern recognition and knowledgeable interpretation of laboratory findings facilitates diagnosis. Psychotropics and antibiotics may help improve functioning and prevent further disease progression.ConclusionsLD is relatively rare, but awareness of the association between LD and neuropsychiatric presentations can improve understanding of the causes of mental illness and result in more effective prevention, diagnosis and treatment.DisclosureNo significant relationships.
Reviewing the complex link between epilepsy and psychosis. A case report
Authors: Albarracin P. , Cabañas M. Jiménez , Herrero E. , Galeron R. , Naval M. Huete , Recio A. Garcia 
Published: February 2022

IntroductionWe present the case of a 56 year old woman with a diagnose of Complex Partial Seizures since her teenage years, with a history of multiple hospitalizations in the psychiatric ward of our hospital and a challenging clinical evolution.ObjectivesTo review the different kinds of psychotic disorders that may arise in relation to epilepsia.MethodsLiterature review of scientific papers and classic textbooks on the issue, including references in both Spanish and English languages.ResultsFrom 2008 to 2011 our patient was hospitalized with episodes of different clinical features leading to different diagnoses (in 2008 the episode was compatible with a maniac phase and led to a diagnosis of possible Bipolar Disorder, in 2010 dissociative-like symptoms became more prominent and led to a diagnose of Dissociative Identity Disorder and in 2011 the symptoms pointed to an interictal depression), and a subsequent symptomatology that made clinicians consider a diagnose of unspecified schizophrenia. From 2015 to 2020 our patient suffered multiple decompensations resulting in up to six new hospitalizations, with psychotic symptoms in the shape of auditive hallucinations being consistent and affective symptoms varying widely. This evolution suggests a plausible diagnose of interictal chronic psychosis with bipolar-like affective episodes.ConclusionsAn extensive review of the available scientific literature shows, as so does this case, that along the course of an epileptic disease both schizophrenia-like psychosis and affective psychosis may arise, and that those might be divided along the categories of peri ictal and inter ictal disorders.DisclosureNo significant relationships.
Description of the consumption of toxics in patients with assertive community treatment and prolonged release treatment
Authors: Garcia L. , Rodriguez C. , Willems A.I. 
Published: February 2022

IntroductionThe Assertive Community Treatment (ACT) was developed by Leonard Stein and Mary Ann. The objective is the treatment of serious Mental Disorders in an integral way and in the community.ObjectivesThe Assertive Community Treatment (ACT) was developed by Leonard Stein and Mary Ann. The objective is the treatment of serious Mental Disorders in an integral way and in the community.MethodsThis is a retrospective study with a total of 69 patients whose main diagnosis is Schizophrenia undergoing CT follow-up in 2018-2019. The data obtained have been analyzed by the SPSS statistical program.ResultsOur sample is mainly composed of men (60.9%) with an average age of 48 years (+ - 11.56). The main diagnosis is schizophrenia (62.3%) and the most commonly used long-term injectable treatment is paliperidone palmitate with a dose range of 150mg. Of the total number of patients, 29% of the cases did not maintain active use of any toxic, and the most commonly used toxic is tobacco (49.3% of cases).ConclusionsThe inclusion of patients in a ACT program requires a diagnosis of severe Mental Disorder and poor therapeutic adherence. After analyzing our data, we observed that most of them also have active toxic consumption and high doses of psychotropic drugs.DisclosureNo significant relationships.
Impact of the COVID-19 pandemic in a substance use harm reduction setting
Authors: Frias P. , Vilares J. 
Published: February 2022

IntroductionHarm reduction (HR) approaches substance use disorders (SUDs) from a standpoint of humanism and tolerance, understanding the difficulty of terminating consumption in some cases, and instead promoting practices aimed at reducing risks inherent to substance use while granting accessibility to comunity based healthcare and contact with differentiated care, when needed, to patients who otherwise wouldn’t have access to it. The COVID-19 pandemic brought about an economic crises, impacting mainly people from lower classes, associated with an increased prevalence of heroine and crack cocaine use and exacerbating previous SUDs.ObjectivesDescribe changes in a HR population treated in HR context in Gaia, Portugal.MethodsData was retrieved from clinical files of patients undergoing treatment in a Harm Reduction setting on the HR team “GiruGaia” from Porto. Analysed data included number of patients admitted to treatment in the period between march the 1st and december the 30th 2020, their sociodemographic data, psychiatric and substance use history, psychiatric treatment and opioid agonist treatment when required. Gathered data was compared to the same time period in previous years.ResultsThe number of patients admitted to treatment drastically increased. Patients presented with poorer socioeconomic conditions, more psychiatric comorbidity and in need of more extensive treatment interventions.ConclusionsOur findings suggest that the pandemic and it’s socioeconomic impact affected drug users in need of HR interventions worsening underlying psychiatric disorders, poverty and inacessibility to healthcare. Drug users are often a forgotten population, and our results indicate that more attention should be devoted to them.DisclosureNo significant relationships.
The program of complex differentiated medical and psychological rehabilitation of suicidal behavior in dementia
Authors: Mudrenko I. , Potapov O. , Alswaeer E. 
Published: February 2022

IntroductionThe course of dementia is accompanied by aggression, wandering, agitation, sexual and eating disorders, suicidal behavior (SB).ObjectivesDevelop and approbate a program of medical and psychological rehabilitation (MPRP) SB in patients with dementia.MethodsIt were treated 199 patients with SB in dementia of which 107 get cured according to the developed programs and 92 people received traditional treatment.ResultsThe program of MPRP combines pharmacotherapy, psychotherapy psychoeducation, psychological training and developed taking into account the mechanisms and predictors of SB. The program included phases: diagnostic phase, phase of active intervention, psychoprophylactic phase. Pathogenetic treatment of dementia was performed with acetylcholinesterase inhibitors and / or NMDA-receptor blockers for 4-6 months. Patients with dementia with a depressive mechanism of SB were additionally prescribed antidepressants from the class of SSRIS for 3-4 months; with the psychotic mechanism of SB – atypical neuroleptics (risperidone, quetiapine) for 2-3 months. The system of psychotherapeutic and psychosocial intervention included rational and family psychotherapy, cognitive training, self-care training and psychoeducation for patients with the cognitive mechanism of SB – art therapy and family psychotherapy, communicative trainings and psychoeducation for patients with the depressive mechanism of SB; crisis psychotherapy and art therapy, social skills training and psychoeducational classes for patients with a psychotic mechanism. Improvement of mental state and reduction of symptoms of SP were diagnosed in 72.9% of patients, and after the use of traditional forms of prevention – only in 40.2% (DC=2.58; MI=0.43, p>0.001).ConclusionsThe results of approbation MPRP program in SB testify to its effectiveness.DisclosureNo significant relationships.
The regulation of emotions: Gender differences
Authors: Delhom I. , Melendez J.C. , Satorres E. 
Published: February 2022

IntroductionEmotional regulation, understood as the emotional ability to repair emotional states, is a skill closely linked to adaptation during aging. People who are capable to manage their emotions have greater control over moods, applying adaptive regulation strategies that allow them to maintain positive moods and modify or regulate negative ones. It has been observed that gender can be a relevant variable related to emotional regulation. In this sense, it is considered that women may be more skillful than men to emotional regulation strategies, benefiting from more successful emotional management strategies.ObjectivesVerify if there are differences in the ability of emotional regulation between older men and women.MethodsThe sample consisted of 851 healthy older adults, of whom 299 were men and 554 women. The participants were recruited from elderly leisure centers in the city of Valencia (Spain). To assess emotional regulation, the regulation dimension of the Trait Meta-Mood Scale 24 (TMMS-24) was used.ResultsSignificant differences were obtained in the emotional regulation dimension based on gender (F1, 851 = 0.075, p = 0.010), finding higher levels in women than in men (3.64 vs. 3.49).ConclusionsThere is an apparent advantage of women in relation to emotional regulation, showing more skill than men in the management of emotional states. This is an important finding considering the impact of emotional regulation on adaptation during aging. This adaptative advantage has a greate importance in generation pleasant emotional states that contribute to healthy aging.DisclosureNo significant relationships.
Screening for hepatitis C in psychiatric population
Authors: Icole F. , Bronowicki J.-P. , Jeannoel C. , Besancon P. , Boulanger F. 
Published: February 2022

IntroductionA meta-analysis from 2016 estimates prevalence of hepatitis C to be superior in people with severe mental illness than general population. In France, positivity for hepatitis C is estimated at 0,75% of general population and 0.3% with a detectable viral load. No recent study was conducted to determine seroprevalence of hepatitis C in population admitted in psychiatric institution.ObjectivesThe aims of this study are to determine seroprevalence of hepatitis C in population admitted in psychiatric institution and describe the profile of infected patients.MethodsFrom january 2020 to october 2020, screening test for hepatitis C, hepatitis B and HIV was proposed to every patient admitted at the reception unit of Ravenel Hospital. In case of positivity, viral load was realised.ResultsBetween January 7th and Octobre 1st , 407 patients greed to the screening test. Among them, 17 (4,2%) were tested positive to hepatits C and viral load was detectable in 9/17 positives, which lead to a 2,2% seroprevalence of hepatitis C infection in the studied population. The patients with positive screening had a mean age of 40 years old. 82% of them were males. 16 admit using intoxicating substances and 10 were still current users at the time of the study. They were hospitalized for addictology purpose (5/17), psychosis (6/17), mood disorder (5/17), personality disorder (2/17), adjustement disorder (2/7). 10/17 had an alcohol use disorder.ConclusionsThis study confirms seroprevalence of hepatitis C infection in psychiatric population is seven times that of general population. This justifies a systematic screening of this population.DisclosureNo significant relationships.
Relationship quality in couples related to mental health of women and men during the COVID-19 pandemic and stay-at-home orders
Authors: Shaigerova L. , Vakhantseva O. , Almazova O. , Shilko R. , Dolgikh A. 
Published: February 2022

IntroductionThe data on gender differences in mental health make the investigation of the specific impact of the pandemic and of the stay-at-home orders on men and women relevant.ObjectivesThe study focuses on the quality of the relationship in couples and mental health in men and women during the COVID-19 pandemic.MethodsThe study was conducted through an online survey a few weeks after the pandemic was declared and the stay-at-home order was introduced in Russia. 274 participants (50 men and 224 women) engaged in long-term relationships aged from 18 to 62 (M=34.2; SD=9.1) took part in the research. The instruments included the Warwick-Edinburgh Mental Well-Being Scale, the Perceived Relationship Quality Components, and the Depression Anxiety Stress Scales.ResultsWomen show a considerably higher level of stress (t=3.805; p<0.001), depression (t=3.76; p<0.001) and anxiety (t=2.959; p=0.003). The quality of relationship for women is significantly connected with mental wellbeing (r=0.423; p<0.001) and negatively correlated with the stress level (r= -0.60; p<0.001), depression (r= -0,381; p<0,001) and anxiety (r=-0,313; p<0,001). Meanwhile for men, the quality of the relationship is connected to mental wellbeing (r=0.280; p=0.049), opposed to stress levels (r= -0.316; p=0.025) and is neither connected to depression (r= -0.210; p=0.144) nor to anxiety (r= -0.126; p=0.383).ConclusionsDuring the pandemic, a favorable partnership has a positive effect on the mental health of both men and women. However, while the relationship quality affects all investigated indicators of mental health in women, in men the relationship quality is only connected to the level of mental wellbeing and stress. The reported study was funded by RFBR, project number 20-04-60174.DisclosureNo significant relationships.
Occupational burnout syndrome among italian healthcare workers during the COVID-19 pandemic: A real-world study
Authors: Vignapiano A. , Nolfe G. 
Published: February 2022

IntroductionThe coronavirus disease 2019 (COVID-19) experience in 2019/2020 carrieda devastating impact on hospital systems and personnel. Therising number of cases, unpreparedness, lack of vital resources, excessiveworkload, and the incapacityto contain the spread has producedincreased psychological and physical pressure among thehealthcare workers. During thepandemic,the extreme pressures experienced by healthcare workers increasedthe risk ofburnout, which has negative consequences for individual health, but also for patient care andthe healthcare system.ObjectivesOur study has been developed with the aims to evaluate the impact of COVID-19 pandemic on occupational burnout of Italian healthcare workers and to identify the presence of protective and the risk factors.MethodsAn online survey addressed the Italian healthcare workers using email invitation, dissemination of the link through social media channels and involvement of professional associations. The snowball sampling procedure gave us the opportunity to recruit a large sample of the Italian healthcare workers with different role, specialties and settings.ResultsDuring the study period, 5643 responses were recorded. The final sample included 5385 participants. This included 63.2% of medical practitioners, 35.3% of nurses and social workers and 1.5% non-clinical or other. The majority of participants were female (60.7%), 39.4% had at least 20 years of clinical experience and 3170 participants worked in inpatient unit hospital.A subset of participants screened positively for moderate- to-severe symptoms of depression, anxiety. Front-line workers reported high greater severity of psychological distress.ConclusionsUnderstanding the health-related consequences of COVID-19 outbreak on Italian healthcare workers is mandatory to provide timely interventions to protect their health.DisclosureNo significant relationships.
The benefits of involving general practitioners in the promotion of e-health tools for primary prevention of suicide in the general population: The stopblues case
Authors: Jeannic A. Le , Turmaine K. , Chevreul K. 
Published: February 2022

IntroductionIn France about 10,000 suicides/year are recorded. General practitioners (GPs) have an important role in prevention, with consultation rates between 20% and 76% the day preceding suicide. StopBlues is an application/website for primary prevention of suicide in the general population. Its promotion was supported by municipalities and involved GPs.ObjectivesTo evaluate how the involvement of GPs in the promotion of StopBlues had an impact on its utilization.MethodsStopBlues was promoted in 25 French municipalities randomly assigned to a ‘basic’ promotion group organized by municipalities only or an ‘intensified’ promotion group that also includes promotion in GPs’ waiting rooms. StopBlues users were asked how they found out about StopBlues. After two years, an ad hoc questionnaire was sent to all GPs (N=2,111).ResultsStopBlues users from those municipalities (N=885) were 16% to learn about StopBlues from GPs, 93% of them living in municipalities with ‘intensified’ promotion. In the ‘basic’ group, where no GPs have heard about StopBlues, 15% would like to know more about it/will have a look at it and 8% will use it and recommend it to colleagues. Half of GPs from the ‘intensified’ group had heard about the program, with 24% who recommended StopBlues to some patients. 21% of GPs agreed that they will use it and recommend it to colleagues.ConclusionsInvolving GPs in the use of e-health tools is of major interest to improve their utilization. Our results show that GPs are in need of those in dealing with patients with psychological pain/distress.DisclosureNo significant relationships.
ECG changes associated with lithium intoxication – a study based on the lisie project
Authors: Truedson P. , Lindmark K. , Ström M. , Maripuu M. , Werneke U. 
Published: February 2022

IntroductionIt currently remains unclear in how far supratherapeutic lithium serum concentrations can affect the cardiac conduction system. Prolonged QT interval, arrhythmias and cardiac death have all been anecdotally reported, but the systematic studies are few.ObjectivesTo examine ECG changes occurring with supratherapeutic lithium concentrations that have given rise to lithium toxicity.MethodsWe examined all episodes of lithium intoxication defined as serum lithium level (≥ 1.5 mmol/L). We analyzed ECG before, during and after intoxication and recorded ECG changes. These, we then assessed according to type of intoxications, clinical and other pharmacological characteristics. The study is based on 20-year data (1997-2020) from the retrospective cohort study (LiSIE) in the Swedish region of Norrbotten.ResultsOf 1101 patients treated with lithium, 77 patients had experienced lithium intoxications. 12 patients had more than one episode of intoxication, yielding 91 episodes. 39 had ECG available both as reference and during lithium intoxication. We found no statistically significant prolongation of the QTc interval during lithium intoxication, compared to respective reference ECG (p = 0.364). Heart rate during lithium intoxication was significantly lower, mean 73 beats/min (SD 16,8, range 43 - 112), compared to the reference ECG, mean 79 beats/min (SD 15,3, range 48-112; p = 0.006). No patient died. All findings were independent of whether an intoxication was acute or chronic.ConclusionsIn our study, heart rate was significantly lower during episodes of intoxication. However, this decrease was of no clinical relevance in most cases. Lithium intoxication was not associated with prolonged QT time.DisclosureM. Ott: scientific advisory board member of Astra Zeneca, Sweden. U. Werneke: received funding for educational activities on behalf of Norrbotten Region; Astra Zeneca, Eli Lilly, Janssen, Novartis, Otsuka/Lundbeck, Servier, Shire, Sunovion. Others: None
Rates of 1-year cognitive impairment in older adults who developed delirium due to a systemic infection
Authors: Silva A.R. , Cardoso A.L. , Baldeiras I. , Santana I. , Cerejeira J. 
Published: February 2022

IntroductionDelirium affects a significant proportion of hospitalized older patients with acute infections. There is growing evidence that delirium accelerates the cognitive decline at long term.ObjectivesWe aimed to determine if delirium during hospitalization was independently associated with cognitive deterioration at one-year.MethodsFrom a total of 22 patients (12 C, 4 Dem, 2 D, and 4 DD) delirium (D and DD groups) was associated with a worse score in MOCA of 3-points (p<.02) and 2.5-points (p<.03), respectively, at one year, follow up. Dementia patients without delirium had a decrease of 2-point (p=.04) while cognitively healthy patients had a decrease in 1.08 points (p=.05) (Graph1). MOCA and NPI scores during hospitalization correlated significantly with cognitive decline in the four groups (r=.658, p<.01 and r=.439, p=.02, respectively.)ResultsFrom a total of 22 patients (12 C, 4 Dem, 2 D and 4 DD) delirium (D and DD groups) was associated with a worse score in MOCA of 3-points (p<.02) and 2.5-points (p<.03), respectively, at one year follow up. Dementia patients without delirium had a of 2-point (p=.04) while cognitively healthy patients had a decrease in 1.08 points (p=.05) (Graph1). MOCA and NPI scores during hospitalization correlated significantly with cognitive decline in the four groups (r=.658, p<.01 and r=.439, p=.02, respectively.)ConclusionsIndividuals developing delirium while recovering from infection have higher rates of cognitive decline after one year, but the cognitive decline is also present to a lower extent for individuals with infections that did not develop delirium.DisclosureNo significant relationships.