bluuebunny/crossref_metadata_2025_split huggingface dataset:
Białka z rodziny Bcl-2 oraz neurotrofiny jako istotny czynnik decydujący o przeżywalności neuronów obwodowych u zwierząt transgenicznych
Authors: Trzęsicki Michał , Białoń Natalia , Kuźma Damian , Górka Dariusz 
Published: December 2022

Apoptoza jest uporządkowanym, czynnym procesem przebiegającym z aktywacją określonych genów, w wyniku którego komórka może wejść na drogę programowanej śmierci. Podczas embriogenezy, zaprogramowane szablony śmierci komórkowej w regresji struktur pierwotnych lub nieprawidłowych są niezbędne w prawidłowym kształtowaniu narządów i funkcjonowaniu układu nerwowego. Z kolei, nasilona śmiertelność komórek w dojrzałym układzie nerwowym może prowadzić do różnych chorób neurodegeneracyjnych. Z tych powodów rodzina białek Bcl‑2 jest intensywnie badana w kontekście funkcjonowania układu nerwowego. Programowana śmierć komórki (PCD) pozwala eliminować komórki zbędne, przyczyniając się w ten sposób do utrzymania homeostazy w organizmie. Jako przykład można podać usuwanie z tkanek komórek starych, uszkodzonych lub nadliczbowych. Nieprawidłowa regulacja apoptozy charakterystyczna jest dla procesów nowotworowych, zmian zwyrodnieniowych i schorzeń autoimmunologicznych. Obecnie badania nad ekspresją genów białek pro- i antyapoptotycznych, z zastosowaniem technologii knock‑out budzą wielkie nadzieje na leczenie pacjentów, dotkniętych zmianami neurodegeneracyjnymi. Aktualne odkrycia sugerują, że nie bez znaczenia pozostaje stosunek poziomów ekspresji genów białek Bcl‑2 i Bax. Białka Bcl‑2 poprzez regulację kaspazo- zależnej apoptozy w neuronach, zapobiegają szybkiej degeneracji wallerowskiej. Możliwości oddziaływania absencji genu bcl-2 na substancje i czynniki neurotroficzne może mieć przełożenie na proces regeneracji nerwów obwodowych.
Use of Stream of Consciousness in Brick Lane: A Psychoanalytical Approach to Study Nazneen’s Evolution
Authors: Jabin Haque Manfath 
Published: December 2022

This paper attempts an interpretive study of Monica Ali’s use of steam of consciousness in her first novel Brick Lane (2003), examining the psychological connection with this technique to comprehend the protagonist Nazneen’s evolutionary expedition. Brick Lane starts with the stillbirth of Nazneen and by her mother’s influence she learns to accept fate without any question. After her marriage with Chanu, she becomes a British immigrant and embarks her journey to adjust in a new place, new life and to form a new identity beyond the patriarchal constraints. Throughout the novel, she undergoes various internal and external dilemma and troubles; but, she establishes her own identity by attaining economic emancipation and by establishing her logical opinion. This paper purports to interpret step by step journey of ‘a village girl’ Nazneen towards her transformation as an independent woman retaining her native cultural values. The study identifies the stream of consciousness used by the author to reveal the mind’s workings of Nazneen behind her behaviours and activities. This article attempts to explore the psychological interpretation of Nazneen’s thoughts and actions. In this regard, Freud’s theory of ‘unconscious’ and ‘conscious’ mind is used to explore how her stream of consciousness works for the readers to dive deep into the character to comprehend her predicament and upswing. This paper presents, through a psychoanalytical approach, an in-depth textual interpretation of Nazneen’s story with a specific reference to her stream of consciousness.
Field Efficacy of Cowpathy Products and Biological Control Agents in Controlling Banded Leaf and Sheath Blight Disease and Increasing Maize Yield
Authors: Yadav Lokesh , Kumar Ashwani , Punia Rakesh , Yadav Naresh Kumar , Yadav Pankaj 
Published: December 2022

Background: Maize is an important cereal crops as it is a good source of nutrition and raw material for industries. Among various pathogens attacking maize crop, banded leaf and sheath blight (BLSB) caused by Rhizoctonia solani f.sp sasakii is a potential threat for quality maize production. It affects all the plant parts at every stage of crop growth. Methods: The present investigation was carried out at Regional Research Station Uchani, Karnal of CCS Haryana Agricultural University, Hisar to evaluate the efficiency and efficacy of biorational products (Cowpathy) such as Vedic Krishi inputs viz., Beejamrit and Jiwamrit, compost extract and biocontrol agents with the objective to manage banded leaf and sheath disease and increasing yield of maize. Result: All the biorational products were found quite effective in controlling the disease and enhancing the yield attributes. Seed treatment with Achook (Neem based fungicide containing azadirachtin) @ 2 g/l of seed was found most effective in controlling disease upto 51.77 per cent. Seed treatment with Pseudomonas fluorescens @ 10 ml/kg followed by Beejamrit @ 10 ml/kg were also found effective in reducing the disease incidence as compared to control. These are economic, reliable and viable sources and hold good promise for use in organic and sustainable agriculture.
The Role of National Brand “Bangga Buatan Indonesia” to Support MSME Resilience in COVID-19 Crisis
Authors: Wibowo Joshi 
Published: December 2022

Abstract
The weakening of economic activity in Indonesia caused by the spread of the COVID outbreak impacted MSME activities in Indonesia negatively. The Indonesian government has implemented various preventive policies to support local MSME resilience to overcome this issue. One of which is a policy related to the brand nation, “Gerakan Bangga Buatan Indonesia” (BBI). This study aims to determine the role of BBI policies on the resilience of Indonesian MSMEs in the era of the COVID-19 pandemic. The data used in this study were sourced from social media “Twitter” which contains the hashtag #banggabuatanindonesia from March 2020 – March 2021. This study examines tweets related to BBI with matters that affect the resilience of local MSMEs, such as business regulation, financial reform, tax reform, and economic stimulus qualitatively. The results showed that the most affected category to MSME resilience in the COVID-19 pandemic era was digitalization, followed by trade activities, economic stimulus, business regulation, financial reform, and tax reform. The magnitude of the influence of digitalization on MSME resilience was caused by the COVID-19 pandemic, which forces MSME actors to digitize their activities to maintain their business. In addition, this study also found two unique phenomena, which are: (1) digitalization is indirectly integrated into other categories such as trade activities, economic stimulus, and financial reform to support local MSME resilience; (2) The high participation of netizens consisting of the Indonesian people to support BBI policies through the use of the hashtag #banggabuatanindonesia. Overall, BBI policies have a positive impact on the resilience of MSMEs in Indonesia in the new normal era and the post-COVID-19 era.
JEL Code: I15, J18, O14, Z19
Assessment of Direct Tax Collection in India
Authors: Wagle Namrata , Manerkar Manjiri 
Published: December 2022

Abstract
The overall development of society is the primary objective of any government and India is no exception. It should focus on basic functions and on welfare and developmental activities that require finance. Government raises finance for public necessities through tax i.e., direct tax and indirect tax. The tax system in India has come a long way, dating back from the colonial era till now. This paper examines the performance of direct tax collection in India for the period from the financial year 2001-02 to 2018-19. The data has been collected from secondary sources i.e., the website of the Central Board of Direct Taxes (CBDT). It is found that the collection of direct tax witnesses an increasing trend. The direct tax collected from each state in India was analyzed for the period of the study to perceive if there is a statistical difference. Also, the study showcases that the net collection of Direct Tax has a positive impact on GDP of the country.
Increase Corrosion Resistance of Alkyd Paint With Nio-zro2y Coating on Hot-rolled Steel
Authors: Cano Carolina , Malagón Eduard Ricardo Romero , González Gloria Ivonne Cubillos 
Published: December 2022

Abstract
The corrosion resistance of an alkyd paint was evaluated, substituting commercial anticorrosive with a thin film of NiO-ZrO2Y partially stabilized with Ytria deposited by means of the RF sputtering technique. Hot-rolled (HR) steel was used as the substrate. For the two anticorrosive coating systems, the structure, morphology, and composition were determined via the techniques of X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS) in order to determine the composition of the NiO-ZrO2Y film. The corrosion resistance was determined from polarization curves and weight loss by immersion in a 3.5% NaCl solution. The electrochemical and weight loss results indicated that use of the NiO-ZrO2 film shows a fourfold increase in the corrosion resistance of the material subjected to immersion in the corrosive electrolyte compared to the traditionally-used commercial anticorrosive.
The surveillance of patients hospitalised with COVID-19 in Norway: a comparison of two register-based systems
Authors: Whittaker Robert , Toikkanen Salla , Dean Katharine , Lyngstad Trude Marie , Buanes Eirik , Kløvstad Hilde , Paulsen Trine Hessevik , Seppälä Elina 
Published: December 2022

Abstract
Introduction

We compared data in two national electronic health registries to evaluate and further optimise the surveillance of patients hospitalised with COVID-19 in Norway.

Method

We included COVID-19 patients registered in the Norwegian Patient Registry (NPR) or Norwegian Pandemic Registry (NoPaR) with admission dates between 17 February 2020 and 1 May 2022. We linked patients, identified overlapping hospitalisation periods and described the overlap between the registries. We calculated the proportion of ICD-10 diagnosis codes (from NPR) and their combinations by main cause of admission (clinically assessed as COVID-19 or other, from NoPaR), age and time. We also calculated the sensitivity and specificity of selected code combinations for representing U07.1 patients’ main cause.

Results

In the study period, 20,115 admissions with laboratory-confirmed COVID-19 were registered in NoPaR, and 21,030 with the ICD-10 code U07.1 in NPR. Up to late-2021 there was a 90 – 100% overlap between the registries, which thereafter gradually decreased to below 75%. The distribution of ICD-10 codes by main cause and sensitivity and specificity of selected code combinations for representing COVID-19 as main cause varied by age and time.

Conclusion

Changes in patient cohorts, virus characteristics and the management of COVID-19 patients in hospitals from late-2021 impacted the registration of patients in NoPaR and ICD-10 codes in NPR. Using ICD-10 codes for the surveillance of patients hospitalised due to COVID-19 requires age- and time-specific definitions, and ongoing validation to consider temporal changes in patient cohorts and virus characteristics.
A cyanobacterial bloom can be effectively managed by combining different temperatures and light intensity using hydrogen peroxide as an indicator
Authors: Rahman Mizanur , Asaeda Takashi , Abeynayaka Helayaye Damitha Lakmali 
Published: December 2022

Abstract
This study conducted laboratory experiments to evaluate the combined effect of different temperatures and diurnal light intensities on cyanobacteria. After 23 days of incubation of sufficient Microcystis aeruginosa cells at 30°C, 20°C, and 10°C temperatures, the light intensities were changed diurnally hourly by 100 µmol m− 2 s− 1 starting from 6:00 to 18:00, where maximum light intensity reached 600 µmol m− 2 s− 1 at 11:00 to 13:00 and then decreased parallel till 18:00. H2O2, Chl-a, and CAT levels increased until 15:00 but decreased with light intensity afterward. It was found that temperature (30°C to 10°C) significantly influenced H2O2, protein, and Chl-a concentrations. The H2O2/protein concentration significantly correlated with protein concentration in decreasing temperature. CAT activity was directly proportional to H2O2/protein concentration at different temperatures. H2O2/protein was defined as the content of H2O2 within cells. These findings would provide the necessary tools for treating cyanobacterial blooms by using H2O2 as an indicator.
Healthy Sleep Patterns, Genetic Susceptibility, and Incident of Cirrhosis and Liver Cancer
Authors: Wang Haoxue , Qin Shifan , Zhang Shanshan , Shen Qian , Zhu Ying , Tian Jianbo , Chang Jiang , Zhong Rong 
Published: December 2022

Abstract
Introduction: Existing evidence implicated that individual unhealthy sleep behaviors play potential roles in the pathogenesis of liver-related disease. However, the associations of sleep pattern with cirrhosis and liver cancer remains unclear. Therefore, we aim to examine the associations of sleep patterns with cirrhosis and liver cancer incidence in a large prospective cohort and evaluate the role of genetic risks in the associations.
Methods: This study prospectively followed participants from the UK Biobank cohort study who were free of cirrhosis and liver cancer at baseline. Five sleep behaviors were collected to measure sleep pattern. We constructed a polygenic risk score for cirrhosis and liver cancer. Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
Results: During the prospective follow-up of 370,976 participants, we documented 580 cirrhosis and 213 liver cancer incidents. Compared with participants with an unfavourable sleep pattern, multivariable-adjusted HRs (95% CIs) for those with favourable sleep pattern were 0.63 (0.44-0.92) for cirrhosis (Ptrend = 0.001), 0.40 (0.23-0.71) for liver cancer (Ptrend = 0.013), and 0.39 (0.21-0.72) for non-cirrhotic liver cancer (Ptrend = 0.019). Moreover, participants with an unfavourable sleep pattern and a high genetic risk had higher risks of cirrhosis incidence (HR: 3.43, 95% CI: 2.00-5.88) and liver cancer incidence (HR: 3.33, 95% CI: 1.19-9.26) than those with a favourable sleep pattern and a low genetic risk. Conclusions: A healthy sleep pattern was associated with lower risk of cirrhosis and liver cancer, and genetic risk did not modify these associations.
Correlation Between Peri-Implant Bone Mineral Density and Initial Stability of Implants as Interpreted by Artificial Intelligence Jaw Density Classification
Authors: Lv Lingfeng , Xiao Yanjun , Zhou Lin , Guo Jianbin , Lin Yanjun , Chen Jiang , Huang Wenxiu , Wu Dong 
Published: December 2022

Abstract
Objective: To investigate the correlation between peri-implant BMD and initial stability of implants when combined with the new artificial intelligence classification method of jaw density.
Materials and Methods: 49 patients who received dental implant treatment in the Affiliated Hospital of Stomatological of Fujian Medical University were included. The torque value and implant stability quotient (ISQ) value of the implants after implantation were recorded. Artificial intelligence image segmentation software was used to obtain the distribution of jaw density in implant areas, and the neck, the middle, the bottom and the total bone mineral density (BMD) coefficients of the 1mm region around the implant were calculated by model overlap and image overlap techniques. Then, the correlation betwen ISQ and BMD evaluated by a new jaw density artificial intelligence classification method were investigated.
Results: There was a significant positive correlation between the BMD coefficient of the total, the neck and the middle region around implants and the ISQ value (P < 0.05), but there was no significant correlation between the BMD coefficient of the bottom around implants and the ISQ value (P > 0.05). BMD was significantly higher at the implant site with larger implant torque (P < 0.05).
Conclusions：The results of this study suggest that there is a positive correlation between BMD coefficient and the ISQ. BMD of both the neck and the middle of the implant have a significant positive correlation with the ISQ, while BMD of the bottom of the implant has no significant correlation with ISQ.
Untargeted lipidomic analysis and network pharmacology for parthenolide treated papillary thyroid carcinoma cells
Authors: Huang Le-Tian , Li Tie-Jun , Li Ming-Lin , Luo Han-Yong , Wang Yi-Bing , Wang Jia-He 
Published: December 2022

Abstract
Background: With fast rising incidence, papillary thyroid carcinoma (PTC) is the most common head and neck cancer. Parthenolide, isolated from traditional Chinese medicine, inhibits various cancer cells, including PTC cells. The aim was to investigate the lipid profile and lipid changes of PTC cells when treated with parthenolide.
Methods: Comprehensive lipidomic analysis of parthenolide treated PTC cells was conducted by using a UHPLC/Q-TOF-MS platform, and the changed lipid profile and specific altered lipid species were explored. Network pharmacology and molecular docking were performed to show the associations among parthenolide, changed lipid species, and potential target genes.
Results: With high stability and reproducibility, a total of 34 lipid classes and 1736 lipid species were identified. Lipid class analysis indicated that parthenolide treated PTC cells contained higher levels of fatty acid (FA), cholesterol ester (ChE), simple glc series 3 (CerG3) and lysophosphatidylglycerol (LPG), lower levels of zymosterol (ZyE) and Monogalactosyldiacylglycerol (MGDG) than controlled ones, but with no significant differences. Several specific lipid species were changed significantly in PTC cells treated by parthenolide, including the increasing of phosphatidylcholine (PC) (12:0e/16:0), PC (18:0/20:4), CerG3 (d18:1/24:1), lysophosphatidylethanolamine (LPE) (18:0), phosphatidylinositol (PI) (19:0/20:4), lysophosphatidylcholine (LPC) (28:0), ChE (22:6), and the decreasing of phosphatidylethanolamine (PE) (16:1/17:0), PC (34:1) and PC (16:0p/18:0). Four key targets (PLA2G4A, LCAT, LRAT, and PLA2G2A) were discovered when combining network pharmacology and lipidomics. Among them, PLA2G2A and PLA2G4A were able to bind with parthenolide confirmed by molecular docking.
Conclusions: The changed lipid profile and several significantly altered lipid species of parthenolide treated PTC cells were observed. These altered lipid species, such as PC (34:1), and PC (16:0p/18:0), may be involved in the antitumor mechanisms of parthenolide. PLA2G2A and PLA2G4A may play key roles when parthenolide treated PTC cells.
Preliminary issues in the reverse engineering of an spur gear with non-standard geometric parameters
Authors: Konecki Karol , Wojtkowiak Dominik , Talaśka Krzysztof 
Published: December 2022

Abstract
The paper presents issues related to an attempt to recreate the geometry of an involute spur gear with non-standard geometric parameters such as: module m = 4.98 mm, radial clearance factor c* = 0.383, addendum modification y = 0.795, profile shift x = 0.0695, profile angle α = 26.325° and with straight teeth, made in the 6 degree IT, using conventional techniques and measuring instruments. In the process of recreating the geometry of the tested gear, a completely different set of parameters was obtained: m = 5 mm, c* = 0.418, y = 0.81, x = 0.0143, α = 26.806°. The correctness of the reconstructed geometry was assessed by comparing the position of the contour of the involute of the nominal gear with the contour of the involute of the reconstructed gear, establishing that the error value ∆e along the radius leading tangent to the base circle of the restored gear was 0.0054 mm. However, the most important stage of this work is to demonstrate that two involute gears with straight teeth can be identical despite using different geometric parameters in most of them (including, in particular, different modules m and different nominal profile angles α). A formula was derived to calculate the exact value of the profile shift for a new, alternative set of geometric parameters with a different module. A matrix was developed that allows making calculations to derive two identical gears with alternative sets of geometric parameters. Therefore, a proper and valid alternative set of geometric parameters was adopted for the reproduced gear for which the modulus was m = 5 mm, together with c* = 0.380, y = 0.793, x = 0.0325, α = 26.784°. The paper also outlines further research plans.
Numerical Stability of Hanging Cables’ Parametric Vibration during Fastening-Hanging Cantilever Construction Stage of Arch Bridge
Authors: guo zengwei , Tang Xinyu , Yao Guowen 
Published: December 2022

Abstract
The cable-stayed fastening-hanging cantilever construction method has been widely used in the construction of arch bridges. Hanging cables’ parametric vibration frequently appears during the cantilever construction stage of arch rings. However, there is a lack of research on hanging cables’ parametric vibration as well as its control strategies for inerter dampers. Although Runge-Kutta method can achieve the transient response of cables’ parametric vibration under arbitrarily support excitation, it might not achieve the large-amplitude solution due to inappropriate initial conditions. Therefore, parametric vibration equation of hanging cable with parallel inerter damper was established and solved both by Runge-Kutta method and method of multiple scales(MMS). The steady-state solution of hanging cables calculated by Runge-Kutta method and its dependence on initial conditions were discussed and analyzed. Numerical stability of Runge-Kutta solution was also investigated by analyzing the phase portraits of multiple-scale solution. Besides, the influence of inerter damper on Runge-Kutta solutions’ numerical stability and initial condition dependence was discussed and explained. Finally, a general method to determine initial conditions of Runge-Kutta method was proposed to achieve large-amplitude solution of hanging cables’ parametric vibration under arbitrary support excitation. The results indicate that different initial conditions cause Runge-Kutta’s transient amplitude to develop along different phase trajectories, and finally to converge to different steady-state solutions. The inerter damper changes the critical phase trajectory of cable-inerter system, which shifts the region of reasonable initial conditions. Runge-Kutta steady-state solutions with inerter damper, solved by the initial conditions for no inerter damper case, may be the small-amplitude solutions, which may lead to overestimation of the control effect of inerter dampers. This study provides a general method to determine initial conditions of Runge-Kutta method for cables’ parametric vibration, which provides a reference for future parametric vibration studies.