bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between PCV13 pneumococcal vaccination and risk of hospital admissions due to pneumonia or sepsis among patients with haematological malignancies: a single-centre retrospective cohort study in Israel
Authors: Draliuk Regina , Shadmi Efrat , Preis Meir , Dagan Efrat 
Published: April 2022

ObjectivesPatients with haematological malignancies receiving immunosuppressive therapy are at highest risk of invasive pneumococcal disease. Our goal was to investigate whether vaccination of haematological patients with pneumococcal 13-valent conjugated vaccine (PCV13) prior to therapy initiation is associated with decreased hospital admissions due to pneumonia or sepsis within 12 months.Design and settingA longitudinal retrospective cohort study was conducted at the haematology unit of Carmel Medical Center, Israel.ParticipantsInformation on adult patients (>18 years) who were diagnosed between 1 January 2009 and 30 December 2019 with haematological malignancies and received immunosuppressive therapy was retrieved from the electronic health records. Patients with haematological malignancies who received the PCV13 vaccination during or after initiation of the immunosuppressive therapy were excluded from the study.Outcome measuresA multivariate logistic regression model was performed to determine whether PCV13 vaccination is associated with fewer hospital admissions due to pneumonia or sepsis.ResultsThe cohort included 616 patients, of which 418 (67%) patients were not vaccinated and 198 (33%) were vaccinated. Within 12 months, 15.1% (n=63) of non-vaccinated patients compared with only 7.1% (n=14) of the vaccinated patients were hospitalised due to pneumonia or sepsis. The logistic regression analysis demonstrated that receiving PCV13 vaccination is associated with 45% (OR=0.45, 95% CI: 0.246 to 0.839, p=0.012) reduced odds of being hospitalised due to pneumonia or sepsis in patients with haematological malignancies receiving immunosuppressive therapy.ConclusionThis is the first observational study to demonstrate the association between PCV13 vaccination and hospital admissions in patients with haematological malignancies receiving immunosuppressive therapy. Patients receiving PCV13 vaccination before immunosuppressive therapy initiation had significantly reduced odds of hospitalisation due to pneumonia or sepsis compared with non-PCV13-vaccinated patients.
Allophone immigrant women’s knowledge and perceptions of epidural analgesia for labour pain: a qualitative study
Authors: Dominicé Dao Melissa , Gerosa Désirée , Pélieu Iris , Haller Guy 
Published: April 2022

ObjectivesTo explore allophone immigrant women’s knowledge and perceptions of epidural analgesia for labour pain, in order to identify their information needs prior to the procedure.DesignWe conducted focus groups interviews with allophone women from five different linguistic immigrant communities, with the aid of professional interpreters. Thematic analysis of focus group transcripts was carried out by all authors.SettingWomen were recruited at two non-profit associations offering French language and cultural integration training to non-French speaking immigrant women in Geneva.ParticipantsForty women from 10 countries who spoke either Albanian, Arabic, Farsi/Dari, Tamil or Tigrigna took part in the five focus groups. Four participants were nulliparous, but all others had previous experience of labour and delivery, often in European countries. A single focus group was conducted for each of the five language groups.ResultsWe identified five main themes: (1) Women’s partial knowledge of epidural analgesia procedures; (2) Strong fears of short-term and long-term negative consequences of epidural analgesia during childbirth; (3) Reliance on multiple sources of information regarding epidural analgesia for childbirth; (4) Presentation of salient narratives of labour pain to justify their attitudes toward epidural analgesia; and (5) Complex community positioning of pro-epidural women.ConclusionsWomen in our study had partial knowledge of epidural analgesia for labour pain and held perceptions of a high risk-to-benefits ratio for this procedure. Diverse and sometimes conflicting information about epidural analgesia can interfere with women’s decisions regarding this treatment option for labour pain. Our study suggests that women need comprehensive but also tailored information in their own language to support their decision-making regarding epidural labour analgesia.
Estimating excess visual loss from neovascular age-related macular degeneration in the UK during the COVID-19 pandemic: a retrospective clinical audit and simulation model
Authors: Thomas Darren S , Warwick Alasdair , Olvera-Barrios Abraham , Egan Catherine , Schwartz Roy , Patra Sudeshna , Eleftheriadis Haralabos , Khawaja Anthony , Lotery Andrew , Muller Philipp L , Hamilton Robin , Preston Ella , Taylor Paul , Tufail Adnan 
Published: April 2022

ObjectivesTo report the reduction in new neovascular age-related macular degeneration (nAMD) referrals during the COVID-19 pandemic and estimate the impact of delayed treatment on visual outcomes at 1 year.DesignRetrospective clinical audit and simulation model.SettingMultiple UK National Health Service (NHS) ophthalmology centres.ParticipantsData on the reduction in new nAMD referrals were obtained from four NHS Trusts comparing April 2020 with April 2019. To estimate the potential impact on 1-year visual outcomes, a stratified bootstrap simulation model was developed drawing on an electronic medical records dataset of 20 825 nAMD eyes from 27 NHS Trusts.Main outcome measuresSimulated mean visual acuity and proportions of eyes with vision ≤6/60, ≤6/24 and ≥6/12 at 1 year under four hypothetical scenarios: 0-month, 3-month, 6-month and 9-month treatment delays. Estimated additional number of eyes with vision ≤6/60 at 1 year nationally.ResultsThe number of nAMD referrals dropped on average by 72% (range 65%–87%). Simulated 1-year visual outcomes for 1000 nAMD eyes with a 3-month treatment delay suggested an increase in the proportion of eyes with vision ≤6/60 from 15.5% (13.2%–17.9%) to 23.3% (20.7%–25.9%), and a decrease in the proportion of eyes with vision ≥6/12 (driving vision) from 35.1% (32.1%–38.1%) to 26.4% (23.8%–29.2%). Outcomes worsened incrementally with longer modelled delays. Assuming nAMD referrals are reduced to this level for 1 month nationally, these simulated results suggest an additional 186–365 eyes with vision ≤6/60 at 1 year.ConclusionsWe report a large decrease in nAMD referrals during the COVID-19 lockdown and provide an important public health message regarding the risk of delayed treatment. As a conservative estimate, a treatment delay of 3 months could lead to a >50% relative increase in the number of eyes with vision ≤6/60 and 25% relative decrease in the number of eyes with driving vision at 1 year.
Performance and resource requirements of in-person versus voice call versus automated telephone-based socioeconomic data collection modalities for community-based health programmes: a systematic review protocol
Authors: Allen Luke Nelson , Mackinnon Shona , Gordon Iris , Blane David , Marques Ana Patricia , Gichuhi Stephen , Mwangi Alice , Burton Matthew J , Bolster Nigel , Macleod David , Kim Min , Ramke Jacqueline , Bastawrous Andrew 
Published: April 2022

IntroductionGathering data on socioeconomic status (SES) is a prerequisite for any health programme that aims to assess and improve the equitable distribution of its outcomes. Many different modalities can be used to collect SES data, ranging from (1) face-to-face elicitation, to (2) telephone-administered questionnaires, to (3) automated text message-based systems. The relative costs and perceived benefits to patients and providers of these different data collection approaches is unknown. This protocol is for a systematic review that aims to compare the resource requirements, performance characteristics, and acceptability to participants and service providers of these three approaches to collect SES data from those enrolled in health programmes.Methods and analysisAn information specialist will conduct searches on the Cochrane Library, MEDLINE, Embase, Global Health, ClinicalTrials.gov, the WHO ICTRP and OpenGrey. All databases will be searched from 1999 to present with no language limits used. We will also search Google Scholar and check the reference lists of relevant articles for further potentially eligible studies. Any empirical study design will be eligible if it compares two or more modalities to elicit SES data from the following three; in-person, voice call, or automated phone-based systems. Two reviewers will independently screen titles, abstracts and full-text articles; and complete data extraction. For each study, we will extract data on the modality characteristics, primary outcomes (response rate and equivalence) and secondary outcomes (time, costs and acceptability to patients and providers). We will synthesise findings thematically without meta-analysis.Ethics and disseminationEthical approval is not required, as our review will include published and publicly accessible data. This review is part of a project to improve equitable access to eye care services in low-ioncome and middle-income countries. However, the findings will be useful to policy-makers and programme managers in a range of health settings and non-health settings. We will publish our findings in a peer-reviewed journal and develop an accessible summary of results for website posting and stakeholder meetings.PROSPERO registration numberCRD42021251959.
Types of anticipated affect that encourage and discourage vaccination: a scoping review protocol
Authors: Okuhara Tsuyoshi , Okada Hiroko , Goto Eiko , Tsunezumi Aiko , Kagawa Yumi , Kiuchi Takahiro 
Published: April 2022

IntroductionVarious cognitive behavioural models and theories have been used to address vaccine hesitancy. However, those models and theories have been criticised for focusing on cognitive influences on health behaviours at the expense of affective influences. Recent studies have highlighted the importance of affective elements as complementary predictors of health behaviours. Anticipated affect (ie, an expectation of one’s affective response to the target behaviour) has received the most scrutiny. This scoping review will analyse studies of anticipated affect that aimed to encourage vaccination and organise implications for future research and practice in vaccine communication. Our report will focus on exploring the usefulness of affective influence in terms of a comparison with the cognitive influence on vaccination.Methods and analysisWe will search several databases (MEDLINE, CINAHL, PsycINFO, PsycARTICLES, Academic Search Complete, Embase, Scopus, Web of Science and Google Scholar) and identify additional literature by searching the reference lists of eligible studies. Eligible studies are those that quantitatively or qualitatively examined anticipated affect and aimed to encourage vaccination. Only papers written in English will be included. We will include all eligible publications from database inception up to the date of the final database search. Two independent reviewers will screen the titles, abstracts and full texts of all identified studies. Two independent reviewers will share responsibility for data extraction and verification. Discrepancies will be resolved through discussion to reach consensus. We will extract data such as study characteristics, type of vaccine, type of anticipated affect, participant characteristics, methodology and main results. Data will be extracted using a customised extraction template on Covidence. The findings will be synthesised in a descriptive, narrative review.Ethics and disseminationThis work does not warrant any ethical or safety review. This scoping review will be presented at a relevant conference and published in a peer-reviewed journal.
Why ‘one size fits all’ is not enough when designing COVID-19 immunity certificates for domestic use: a UK-wide cross-sectional online survey
Authors: Niculaescu Corina Elena , Sassoon Isabel , Landa-Avila Irma Cecilia , Colak Ozlem , Jun Gyuchan Thomas , Balatsoukas Panagiotis 
Published: April 2022

ObjectivesThe present study explored public’s willingness to use COVID-19 immunity certificates across six different domestic scenarios.DesignCross-sectional online survey.SettingUK representative survey conducted on 3 August 2021.Participants534 UK residents over 18 years old.InterventionsParticipants replied to the same set of questions.Primary and secondary outcome measuresThe primary outcome measure was willingness to use immunity certificates across three different domestic settings: (1) visiting the general practitioner (GP) for a non-urgent health issue; (2) dining in a restaurant and (3) attending a performance in a theatre. For each setting two options, one prioritising convenience (option A) and the other privacy (option B), were offered. Our secondary outcome measures were computed indices from items adapted from the Health Belief Model; attitudes towards sharing immunity status with service providers; prior to COVID-19 lifestyle. In addition, we recorded data about respondents’ sociodemographic characteristics.ResultsRespondents were more willing to use immunity certificates that prioritised convenience (92%), rather than privacy (76%), when visiting their GP . However, privacy was more favourable in the other two settings (dining in a restaurant (84%) and going to a theatre (83%)) compared with convenience (38% and 39% respectively). Personal beliefs about COVID-19 and immunity certificates were associated with variations in willingness to use these across all scenarios. No variations were observed across sociodemographics and lifestyle.ConclusionsThe findings of this survey suggest that there is not one-size-fits-all solution for designing immunity certificates. Immunity certificates are complex sociotechnical systems, any attempt to implement these for domestic use should be tailored to different settings and user needs. The design of certification services requires a more evidence-based approach and further research is needed to understand how different settings, design elements (like convenience or privacy) and personal beliefs about the pandemic should inform their design.
Quality and reliability evaluation of online videos on carpal tunnel syndrome: a YouTube video-based study
Authors: Kwak Donghee , Park Jong Woong , Won Yousun , Kwon Yeongkeun , Lee Jung Il 
Published: April 2022

ObjectivesWith the increasing popularity of searches for medical information on YouTube, the availability of videos concerning carpal tunnel syndrome (CTS) is increasing. This study aimed to evaluate the quality and reliability of YouTube videos on CTS.Setting and participantsNo participants were included.Primary and secondary outcome measuresWe searched YouTube on 1 April 2021 using the keywords “carpal tunnel syndrome” and “carpal tunnel release” and evaluated the first 55 retrieved videos. We summarised the video characteristics including Video Power Index (VPI), which was designed to evaluate video popularity based on the number of likes and views. We categorised them based on source and content. Video quality and reliability were evaluated using the Journal of the American Medical Association (JAMA) benchmark criteria, the Global Quality Score (GQS) and the Carpal Tunnel Syndrome-Specific Score (CTS-ss) .ResultsThe mean (range: minimum–maximum) of JAMA scores, GQS and CTS-ss were 2.13 (1–4), 2.69 (1–5), and 5.0 (1–15), respectively. The most common source of video was from allied health workers, and academically sourced videos had the highest JAMA score and GQS. Three scores were significantly correlated with each other. Multiple linear regression analysis showed that a higher JAMA score was associated with a higher likes ratio, and a higher GQS was associated with a longer video running time and greater number of comments. However, a higher VPI was not associated with higher video quality or reliability represented by the three scores.ConclusionsYouTube videos on CTS have low quality and reliability. Video popularity was not significantly correlated with quality or reliability. Our findings suggest that expert groups should provide and promote high-quality video content to YouTube users and patients.
Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at
Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised
controlled trial to improve gait and cognition in individuals at risk for
dementia
Authors: McGibbon Chris , Jarrett Pam , Handrigan Grant , Bouchard Danielle , Tranchant Carole C , Sexton Andrew M , Yetman Linda , Robinson Bryn , Crapoulet Stephanie , Chamard-Witkowski Ludivine , Liu-Ambrose Teresa , Middleton Laura Elizabeth , Almeida Quincy J , Bherer Louis , Lim Andrew , Speechley Mark , Kamkar Nellie , Montero Odasso Manuel 
Published: April 2022

Introduction
Physical exercise and cognitive training have the potential to
enhance cognitive function and mobility in older adults at risk of
Alzheimer’s disease and related dementia (ADRD), but little is known
about the feasibility of delivering multidomain interventions in home
settings of older adults at risk of ADRD. This study aims to assess the
feasibility of home-based delivery of exercise and cognitive
interventions, and to evaluate the relationship between participants’
intervention preferences and their subsequent adherence. Secondary
objectives include the effect of the interventions on ADRD risk factors,
including frailty, mobility, sleep, diet and psychological
health.

Methods and analysis
The SYNchronising Exercises, Remedies in GaIt and Cognition at Home
(SYNERGIC@Home) feasibility trial is a randomised control trial that
follows a 2×2 factorial design, with a 16-week home-based intervention
programme (3 sessions per week) of physical exercises and cognitive
training. Participants will be randomised in blocks of four to one of
the following four arms: (1) combined exercise (aerobic and
resistance)+cognitive training (NEUROPEAK); (2) combined
exercise+control cognitive training (web searching); (3) control
exercise (balance and toning)+cognitive training; and (4) control
exercise+control cognitive training. SYNERGIC@Home will be implemented
through video conferencing. Baseline and post-intervention assessments
at 4-month and 10-month follow-up will include measures of cognition,
frailty, mobility, sleep, diet and psychological health. Primary
feasibility outcome is adherence to the interventions. Primary analytic
outcome is the relationship between pre-allocation preference for a
given intervention and subsequent adherence to the allocated
intervention. A series of secondary analytic outcomes examining the
potential effect of the individual and combined interventions on
cognitive, mobility and general well-being will be measured at baseline
and follow-up.

Ethics and dissemination
Ethics approval was granted by the relevant research ethics boards.
Findings of the study will be presented to stakeholders and published in
peer-reviewed journals and at provincial, national and international
conferences.

Trial registration number
NCT04997681, Pre-results.
Transplantation Without Overimmunosuppression (TWO) study protocol: a phase 2b randomised controlled single-centre trial of regulatory T cell therapy to facilitate immunosuppression reduction in living donor kidney transplant recipients
Authors: Brook Matthew Oliver , Hester Joanna , Petchey William , Rombach Ines , Dutton Susan , Bottomley Matthew James , Black Joanna , Abdul-Wahab Seetha , Bushell Andrew , Lombardi Giovanna , Wood Kathryn , Friend Peter , Harden Paul , Issa Fadi 
Published: April 2022

IntroductionRegulatory T cell (Treg) therapy has been demonstrated to facilitate long-term allograft survival in preclinical models of transplantation and may permit reduction of immunosuppression and its associated complications in the clinical setting. Phase 1 clinical trials have shown Treg therapy to be safe and feasible in clinical practice. Here we describe a protocol for the TWO study, a phase 2b randomised control trial of Treg therapy in living donor kidney transplant recipients that will confirm safety and explore efficacy of this novel treatment strategy.Methods and analysis60 patients will be randomised on a 1:1 basis to Treg therapy (TR001) or standard clinical care (control). Patients in the TR001 arm will receive an infusion of autologous polyclonal ex vivo expanded Tregs 5 days after transplantation instead of standard monoclonal antibody induction. Maintenance immunosuppression will be reduced over the course of the post-transplant period to low-dose tacrolimus monotherapy. Control participants will receive a standard basiliximab-based immunosuppression regimen with long-term tacrolimus and mycophenolate mofetil immunosuppression. The primary endpoint is biopsy proven acute rejection over 18 months; secondary endpoints include immunosuppression burden, chronic graft dysfunction and drug-related complications.Ethics and disseminationEthical approval has been provided by the National Health Service Health Research Authority South Central—Oxford A Research Ethics Committee (reference 18/SC/0054). The study also received authorisation from the UK Medicines and Healthcare products Regulatory Agency and is being run in accordance with the principles of Good Clinical Practice, in collaboration with the registered trials unit Oxford Clinical Trials Research Unit. Results from the TWO study will be published in peer-reviewed scientific/medical journals and presented at scientific/clinical symposia and congresses.Trial registration numberISRCTN: 11038572; Pre-results.