bluuebunny/crossref_metadata_2025_split huggingface dataset:
Centrosomal protein55 enhances melanoma cell proliferation, invasion and migration through PI3K/AKT signaling
Authors: Hua Huaikang , Yang Huifang 
Published: November 2022

Purpose: To investigate the role of centrosomal protein55 (CEP55) in melanoma.
Methods: The CEP55 expression in human melanoma cells and normal human melanocytes were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blot. Cell proliferation was evaluated by colony formation and CCK8 assays, while cell cycle was assessed by flow cytometry. Transwell assay was used to investigate cell migration and invasion.
Results: The CEP55 protein expression was higher in A-2058 and A375 melanoma cells than in normal HEMn-LP cells. Overexpression of CEP55 increased melanoma cell viability and the number of melanoma cell colonies (p < 0.01), while CEP55 silencing reduced melanoma cell viability and proliferation. Overexpression of CEP55 promoted cell cycle (p < 0.01) via decreased p21 expression, but increased CyclinD1 and CDK1 expression. Knockdown of CEP55 enhanced p21 expression and reduced CyclinD1 and CDK1 expression to induce cell cycle arrest. Knockdown of CEP55 suppressed melanoma cell migration and invasion by downregulating p-AKT and p-PI3K.
Conclusion: Centrosomal protein55 functions as an oncogene in melanoma by activating PI3K/AKT signaling. Therefore, CEP55 might be a promising target for melanoma diagnosis and treatment.
ANALISIS PELAKSANAAN SISTEM INFORMASI KESEHATANDI PUSKESMAS PABUARAN KABUPATEN SERANG
Authors: Yunita Shalsha , Wahyuni Sri , Syamiyah Najah 
Published: November 2022

Penyelenggaraan Sistem Informasi Kesehatan (SIK) merupakan salah satu upaya yang dilakukan untuk mencapai tujuan pembangunan kesehatan serta merupakan pelayanan penunjang dalam upaya kesehatan di Puskesmas. Berdasarkan Kepmenkes RI Nomor 192/MENKES/SK/VI/2012. Puskesmas pabuaran adalah salah satu puskesmas dikabupaten serang, sudah ada sistem isnformasi kesehatan yang merupakan bagian dari sitem informasi kesehatan kabupaten, hanya dalam pelaksanaan SIK di Puskesmas Pabuaran kabupaten Serang masih manual sehingga data yang dihasilkan tidak tepat waktu. Penelitian ini bertujuan untuk menganalisis pelaksanaan sistem informasi kesehatan di Puskesmas Pabuaran Kabupaten Serang. Penelitian ini adalah jenis penelitian kualitatif. Jumlah informan dalam penelitian ini adalah sebanyak 4orang. Pengumpulan data melalui wawancara, observasi dan penelusuran dokumen. Hasil penelitian menunjukkan bahwa pengelolaan/pelaksanaan SIK belum online, semuanya masih manual. Pengumpulan data dilakukan oleh setiap pemegang program dan pembina desa/bidan desa. Pengiriman data dibawa langsung oleh petugas dari Puskesmas ke Dinas Kesehatan. Pengolahan data sebagian sudah menggunakan komputer namun ada juga yang masih tulis tangan. Di Puskesmas Pabuaran ada Sumber Daya Manusia (SDM) di bidang SIK malah puskesmas membuat program sendiri yang bersifat internal untuk memudahkan mereka dalam pengumpulan data dan pelaporan yaitu aplikasi Cash Poin selain SimKes yang difasilitasi oleh dinas kesehatan terkait. Sarana dan prasarana SIK untuk komputer belum lengkap/tidak merata. Kendala pelaksanaan SIK menyangkut keterbatasan anggaran, masalah internet, serta masalah masalah seperti gunta ganti aplikasi dari dinas kesehatan yang malah membuat lebih membingungkan juga kurang fasilitas pengelolaan dan pengkajian data. Pelaksanaan SIK di Puskesmas Pabuaran Kabupaten Serang belum berjalan sebagaimana mestinya.
SITUASI PENYAKIT KUSTA DI KABUPATEN SERANG TAHUN 2020
Authors: Kurniatillah Nia , Hayat Fauzul , Lusinto Widodo Hari 
Published: November 2022

Kusta merupakan penyakit menular yang masih menjadi permasalahan yang sangat kompleks bagi kesehatan masyarakat Global. Tujuan penelitian ini untuk mengetahui situasi penyakit kusta di Kabupaten Serang. Penelitian ini merupakan penelitian deskriptif dengan metode kuantitatif. Jumlah penderita kusta di Kabupaten Serang tahun 2019 sebanyak 175 kasus dengan angka prevalensi kusta sebesar 1,2 per 100.000 penduduk. Angka penemuan kasus baru sebesar 11,6 per 100.000 penduduk. Penderita kusta tipe Pausi Basiler (PB) dengan jenis kelamin laki-laki (46,2%) dan perempuan (53,8%). Penderita kusta tipe Multipausi Basiler (MB) berjenis kelamin laki-laki (69,8%) dan perempuan (30,2%). Penderita kusta tipe Pausi Basiler (PB) tersebar di 11 wilayah Kecamatan dan tipe Multipausi Basiler (MB), sebaran kasus merata di seluru wilayah di 31 Kecamatan Kabupaten Serang. Terdapat 13 penderita kusta anak < 15 tahun (7,4%). Penderita kusta dengan cacat tingkat 0 (86,9%) dan cacat tingkat 2 (9,7%). Penderita kusta tipe Pausi Basiler (PB) telah menyelesaikan pengobatan (100%). Penderita kusta tipe Multipausi Basiler (MB) telah menyelesaikan pengobatan sebanyak (88,2%). Strategi eleminasi kusta di Kabupaten Serang diperlukan upaya advokasi, kerjasama lintas sektor, program, jejaring kerja serta penguatan kegiatan surveilans kusta. Untuk masyarakat, diperlukan upaya promosi kesehatan melalui media Informasi, Komunikasi dan Edukasi. Peran aktif masyarakat dalam penemuan kasus, deteksi dini dan pengobatan segera.
HUBUNGAN POLA MAKAN DAN PERILAKU MEROKOK DENGAN KEJADIAN HIPERTENSI PADA REMAJA PUTRA DI WILAYAH KERJA PUSKESMAS NAMBO
Authors: Abadi Ellyani , Faisal Faisal , Demmalewa Jenny Qlifianti 
Published: November 2022

Berdasarkan data Dinas Kesehatan Kota Kendari dalam 3 tahun terakhir menunjukkan bahwa kejadian penyakit hipertensi pada usia dewasa (15-18 tahun) yaitu tahun 2017 sebanyak 1.172 kasus. Sedangkan pada tahun 2018 mengalami peningkatan sebanyak 1.249 kasus dan tahun 2019 (Januari- September) penderita Hipertensi pada usia dewasa (15-18 tahun) tercatat 1.097 kasus. Tujuan penelitian ini adalah untuk mengetahui perilaku merokok dan pola makan dengan kejadian hipertensi pada remaja putra di wilayah kerja Puskesmas Nambo. Sampel dalam penelitian ini adalah sebanyak 70 orang remaja putra. Desain penelitian Kuantitatif dengan pendekatan cross sectional. Instrumen penelitian berupa kuesioner dan food frequensi Data dianalisis menggunakan uji Chi-Square. Hasil penelitian menunjukkan bahwa sebagian besar remaja putra tidak hipertensi (62,8%), sebagian besar pola makan remaja putra tidak baik (57,1%), sebagian besar remaja putra perokok (64,2%). Ada hubungan perilaku merokok dengan kejadian hipertensi pada remaja putra di wilayah kerja puskesmas Nambo ditunjukan dengan nilai ρ = 0,000. Tidak ada hubungan pola makan dengan kejadian hipertensi pada remaja putra di wilayah kerja puskesmas Nambo ditunjukan dengan nilai ρ = 0,284. Kesimpulan dari penelitian ini ada hubungan antara perilaku merokok dengan kejadian hipertensi pada remaja putra di wilayah kerja puskesmas Nambo, Tidak ada hubungan pola makan dengan kejadian hipertensi pada remaja putra di wilayah kerja puskesmas Nambo
The polar mesospheric cloud dataset of the Balloon Lidar Experiment (BOLIDE)
Authors: Kaifler Natalie , Kaifler Bernd , Rapp Markus , Fritts David C. 
Published: November 2022

Abstract. The Balloon Lidar Experiment (BOLIDE) observed polar mesospheric clouds (PMCs) along the Arctic circle between Sweden and Canada during the balloon flight of PMC Turbo in July 2018. The purpose of the mission was to study small-scale dynamical processes induced by the breaking of atmospheric gravity waves by high-resolution imaging and profiling of the PMC layer. The primary parameter of the lidar soundings is the time- and range-resolved volume backscatter coefficient β. These data are available at high resolutions of 20 m and 10 s (Kaifler, 2021, https://doi.org/10.5281/zenodo.5722385). This document describes how we calculate β from the BOLIDE photon count data and balloon floating altitude. We compile information relevant for the scientific exploration of this dataset, including statistics, mean values, and temporal evolution of parameters like PMC brightness, altitude, and occurrence rate. Special emphasis is given to the stability of the gondola pointing and the effect of resolution on the signal-to-noise ratio and thus the detection threshold of PMC. PMC layers were detected during 49.7 h in total, accounting for 36.8 % of the 5.7 d flight duration and a total of 178 924 PMC profiles at 10 s resolution. Up to the present, published results from subsets of this dataset include the evolution of small-scale vortex rings, distinct Kelvin–Helmholtz instabilities, and mesospheric bores. The lidar soundings reveal a wide range of responses of the PMC layer to larger-scale gravity waves and breaking gravity waves, including the accompanying instabilities, that await scientific analysis.
The Representation of Causality and Causation with Ontologies: A Systematic Literature Review
Authors: Sawesi Suhila , Rashrash Mohamed , Dammann Olaf 
Published: November 2022

ABSTRACT

Objective: To explore how disease-related causality is formally represented in current ontologies and identify their potential limitations.

Methods: We conducted a systematic literature search on eight databases (PubMed, Institute of Electrical and Electronic Engendering (IEEE Xplore), Association for Computing Machinery (ACM), Scopus, Web of Science databases, Ontobee, Open Biological and Biomedical Ontology
(OBO) Foundry, and Bioportal. We included studies published between January 1, 1970, and December 9, 2020, that formally represent the notions of causality and causation in the medical domain using ontology as a representational tool. Further inclusion criteria were publication in English and peer-reviewed journals or conference proceedings. Two authors (SS, RM) independently assessed study quality and performed content analysis using a modified validated extraction grid with pre-established categorization.

Results: The search strategy led to a total of 8,501 potentially relevant papers, of which 50 met the inclusion criteria. Only 14 out of 50 (28%) specified the nature of causation, and only 7 (14%) included clear and non-circular natural language definitions. Although several theories of causality were mentioned, none of the articles offers a widely accepted conceptualization of how causation and causality can be formally represented.

Conclusion: No current ontology captures the wealth of available concepts of causality. This provides an opportunity for the development of a formal ontology of causation/causality.
(Abstract: 213 words)
UPAYA MENINGKATKAN KOMPETENSI GURU DALAM MENERAPKAN MODEL PEMBELAJARAAN COOPERATIF LEARNING MELALUI SUPERVISI KELAS DI SMP NEGERI 2 SIDAREJA TAHUN PELAJARAN 2021/2022
Authors: Dianawati Lely 
Published: November 2022

Penelitian tindakan sekolah ini bertujuan untuk meningkatkan kompetensi guru dalam menerapkan model pembelajaran cooperatif learning melalui supervisi kelas di SMP Negeri 2 Sidareja Kecamatan Sidareja. Subjek dalam penelitian tindakan sekolah ini adalah 10 orang guru di SMP Negeri 2 Sidareja Kabupaten Cilacap terdiri dari 6 oarang guru laki – laki dan 4 orang guru perempuan. Penelitian ini dilaksanakan dua siklus dan tiap siklusnya terdiri dari dua kali pertemuan yang tiap siklusnya dilaksanakan melalui supervisi kelas. Teknik dan alat pengumpul data melalui tes dan non tes serta melalui observasi. Indikator keberhasilan dalam penelitian ini apabila 85 % dari guru memiliki kompetensi untuk menerapkan model pembelajaran cooperatif learning dan menunjukkan keaktifan. Hasil penelitian menunjukkan peningkatan keaktifan guru , dari 70 % pada siklus I meningkat menjadi 100 % pada siklus II, demikian juga dengan kompetensi guru pada siklus I mencapai 60% meningkat menjadi 100 % pada siklus II. Dengan demikian melalui supervisi kelas dapat meningkatkan kompetensi guru dalam menerapkan model pembelajaran cooperatif learning.
LEGISLATIVE REGULATION OF GENERAL CONDITIONS FOR CERTAIN OF CRIMINAL PROCEEDINGS STAGES
Authors: Лантух Н.В. 
Published: November 2022

В статье осуществлена попытка выделения в отдельную правовую категорию института общих условий, которые действуют на любой стадии уголовного судопроизводства, однако на законодательном уровне регламентированы лишь на стадиях предварительного расследования и судебного разбирательства. Автор осуществляет анализ норм, устанавливающих требования, правила к производству по уголовным делам в каждой стадии уголовного процесса, их обусловленность принципами уголовного судопроизводства, во взаимосвязи с такими категориями уголовно-процессуальной деятельности, как ее задачи, содержание и процессуальный порядок, а также результаты.
The article attempts to separate into a separate legal category of the institution the general conditions that apply at any stage of criminal proceedings, but are regulated at the legislative level only at the stages of preliminary investigation and trial. The author analyzes the norms that establish requirements, rules for criminal proceedings at each stage of the criminal process, their conditionality by the principles of criminal proceedings, in conjunction with such categories of criminal procedural activity as its tasks, content and procedural order, as well as results.
FREQUENCY OF VENTRICULAR SEPTAL RUPTURE AS A COMPLICATION OF ACUTE ST-ELEVATION MYOCARDIAL INFARCTION IN PATIENTS PRESENTING TO A TERTIARY CARE HOSPITAL
Authors: Shahsawar  , Mati ur Rehman  , Muhammad Hammad Sharif  , Zeeshan Afzal  
Published: November 2022

Background: Nearly one-third of the world's population dies from cardiovascular disorders, the majority of which are caused by stroke and coronary artery problems and 80 percent of these fatalities occur in impoverished countries. This study was conducted to determine the frequency of ventricular septal rupture in patients with acute ST-elevation myocardial infarction presenting to cardiology unit Hayatabad Medical Complex Peshawar. Methods: This was descriptive cross sectional research study at the Department of Cardiology, MTI-Hayatabad Medical Complex, Peshawar, from January to July 2020. Detailed history was obtained including duration of symptoms, co-morbidities present and occupation. A thorough clinical examination was done for signs of heart failure and ventricular septal rupture. Patients' demographics, clinical and laboratory parameters were recorded on a pro forma. All the data was analyzed statistically by using SPSS version 24.0. Results: A total of 179 patients were included in our study. Ventricular Septal Rupture (VSR), was recorded in 7 (3.9%) patients having Acute ST elevation of MI. In our study age, obesity, reperfusion therapy, location of MI and history of previous shock were observed to be non-significantly (pË‚0.05) associated with high incidence of Ventricular Septal Rupture in patients having Acute ST elevation of MI. Conclusion: According to our findings, individuals with PI-VSR have a significant risk of acute-phase death. Furthermore, a significant incidence of acute-phase fatalities has been related to female gender and severe cardiac failure upon admission.
A STAB IN THE FORBIDDEN TERRITORY
Authors: Tariq Khuzaima , Asmat Achakzai  , Muneer Amanullah  , Asad Awan  
Published: November 2022

Penetrating heart injuries are associated with higher mortality rates. Coronary lesions caused by penetrating trauma are considered even rarer and universally fatal. We present a case of a fortunate survivor who had complete transection of left anterior descending (LAD) artery with right ventricular (RV) tear after being stabbed by knife, arriving in emergency unit with massively bleeding chest wound. Complex cardiac trauma involving coronaries and cardiac chambers is a challenge to surgeons if patients miraculously reach the hospital alive. This patient had complete transection of LAD artery with penetration into RV cavity, he was successfully managed by timely and prompt surgical intervention by on call team. This case highlights the importance of team dynamics working in harmony during emergency situations, we stress upon conducting routine drills to train surgical residents, perfusionists and operation theatre staff.
EFFECT OF THE FLAVONOID 6-AMINOFLAVONE IN ASPIRIN-INDUCED GASTRIC ULCER IN SPRAGUE-DAWELY RATS: A HISTOMORPHOLOGICAL STUDY
Authors: Tahira Mehreen  , Aamir Shabnum , Nadeem Ali Shah  , Muhammad Shahid  , Irum Javaid  , Munayal Roghani  , Arslan Roghani  , Faizan Roghani  
Published: November 2022

Background: The analgesic drugs are the main cause of gastric ulcer. The objective of this study was to determine the gastroprotective ability of flavonoid, 6-aminoflavone in a rat pyloric ligation model of aspirin associated gastro-ulcerogenesis. Methods: A laboratory based experimental study was conducted in the animal house and research laboratory at Khyber Medical College, Peshawar from July to November 2019. A total of 42 adult male Spargue-Dawely rats were divided into seven groups. Flavonoid, 6-aminoflavone was administered orally in doses of 10, 25 and 100 mg/kg with misoprostol, as standard at 50 µg/kg orally for 4 days. On the last day aspirin was given orally at 200 mg/kg and the pyloric ligation surgery was performed. After 4 hours all animals were killed by cervical dislocation. The gastric tissues were collected for histomorphological study. The obtained data were expressed as mean±SEM. Analysis was carried out by using ANOVA. p value Ë‚0.05 was considered significant. Results: The animals treated with the different doses of 6-aminoflavone showed a marked protective effect in the histological observations. The 10 mg/kg dose had a mild protective effect as occasional ulcerative changes were observed. However, doses of 25 and 100 mg/kg significantly caused the reduction in the ulcer score. These effects produced were equipotent to the gastroprotective effectiveness inherent in the misoprostol. Conclusion: These findings conclude that 6-aminoflavone as like other flavonoids has a significant gastroprotective propensity with significant effect produced at doses of 25 and 100 mg/kg and can be used as a part of therapy management for the treatment of gastrointestinal disease particularly ulcerative condition.
COMPLIANCE TO COLONOSCOPY IN PATIENTS VISITING THE DEPARTMENT OF GASTROENTEROLOGY AT LADY READING HOSPITAL, PESHAWAR
Authors: Durrani Talha , Humayun Omama , Khan Osama Sherjeel , Qazalbash Zeeshan Ali , Durrani Daniyal , Imran Ullah  
Published: November 2022

Background: Colorectal cancer is the largest cause of mortality in patients admitted to any Gastroenterology units. Diagnostic colonoscopy is a valuable tool for the disease's diagnosis and proper treatment but its compliance has been historically low. Our main objective was to find out social, cultural, and psychological barriers among those patients who finally did not show up for their colonoscopy appointment and, make a comparative analysis with those who did. Methods: A cross-sectional study was conducted in the Lady Reading Hospital, Peshawar from October 2021 to March 2022, selecting 224 patients through consecutive sampling. Results: Out of the 224 patients included, males (48.2%) were more likely to show up for the procedure than females (51.8%) (p<0.05). Overall, the most recurring barrier was a lack of knowledge with 116 (51.7%) for both the groups, but especially more for the non-compliant patients (p<0.05). Fear of results, fear of complications of the procedure, and affordability issues stood out as important differences between the compliant and non-compliant patients. Conclusion: For the country's healthcare to be able to overcome these problems, and enter an era where screening colonoscopy is a norm, mass education regarding the issue is imperative.
COMPARISON BETWEEN SUPINE POSITION VERSUS PRONE POSITION IN PERCUTANEOUS NEPHROLITHOTOMY: A SINGLE CENTERED ANALYSIS OF 623 CASES
Authors: Muhammad Nasir Jamil  , Haq Faheem ul , Ehsan ul Islam  , Robina Shaheen  , Umer Farooq  
Published: November 2022

Background: The ideal urological method for treating complex, large renal calculi is Percutaneous nephrolithotomy (PCNL). Its instruments, surgical techniques, and positions have all been adjusted as a result of its ever-changing nature. In PCNL, the supine position is advantageous compared to the prone position due to its several advantages, including the absence of cardiopulmonary risks, fewer post operative complications and shorter operative time. This study was designed for comparison of PCNL in prone and supine positions. Methods: After receiving ethical and research committee approval, this retrospective cohort study (comparative study?) was conducted from 2015 to 2021. Out of 623 patients, PCNL in prone position was performed on 258 patients and 365 patients in modified supine position. The patients' demographics, stone size and location, number of tracts, operating time, hospital stay, stone clearance rate, and post-operative complications were all compared. Results: The gender and age of the patients, the size and number of tracts, and location of the stones were all comparable (p>0.05). Operative time for prone position was 82 min±2.49 SD VS 65 min±2.95 SD, for modified supine position, p<0.001), hospital stay was 58 hrs.±1.66 SD for prone VS 51 Hrs.±1.65 SD, for modified supine position, p<0.01) and analgesia requirements for prone position was 41% VS 23% for modified supine position, p<0.001). The stone clearance rate was 87% in supine position and 89% in the prone positioning group (p=0.47). Urinary leakage from tract site was 0.38% in prone vs. 0% in supine position and temperature >99 °F was 12.4% in prone vs. 11.3% in supine position were the most common post-operative complications. Angioembolization was not observed in either group. Blood transfusions were given to 4.26% in prone position and in 3.58% of cases in supine PCNL. Conclusion: Percutaneous nephrolithotomy in the supine position had a short operating time, short hospital stays, and less analgesia requirements than PCNL in the prone position. In view of the above findings, supine PCNL is easy, quick to perform and having less complications rate as compare to Prone PCNL.
HYPONATREMIA AS A MARKER OF COMPLICATED APPENDICITIS
Authors: Qureshi Muhammad Umer , Asad Iqbal  , Murad Habib  , Muhammad Umar Nisar  , Afia Ayub  , Chaudhary Muhammad Amjad , Babar Sibghatullah 
Published: November 2022

Background: The most frequent cause of paediatric acute abdomen is acute appendicitis. If acute appendicitis is not treated promptly, one third of cases progress to complicated appendicitis. Complicated appendicitis is associated with significant morbidity and its management protocol differs significantly from that of uncomplicated appendicitis. In this study, we assessed the relationship between serum sodium levels and complicated appendicitis. Methods: We conducted a prospective observational study from July to December 2020 at the Department of Neonatal and Paediatric Surgery, The Children Hospital, Pakistan Institute of Medical Sciences, Islamabad, on a sample size of 140 patients who met inclusion and exclusion criteria. For this study, we divided the patients into two groups. Group 1 had uncomplicated appendicitis and Group 2 had complicated appendicitis. These findings were then compared to preoperative serum sodium (Na) levels. Results: The median serum sodium level in group 1 (uncomplicated appendicitis) was 137.81 mg/dl, while in group 2 it was 131.35 mg/dl (Complicated Appendicitis). The sensitivity and specificity of serum sodium levels at a cut-off point of less than 135 mg/dl were 84.80% and 89.40%, respectively. Conclusion: Hyponatremia is currently thought to be a new marker for differentiating between complicated and uncomplicated appendicitis. It is a low-cost, high-efficiency predictive marker for diagnosing and differentiating complicated appendicitis in children.
Complot
Authors: Geelhoed Fiore , De Koster Margo , Cools Marc 
Published: November 2022

Conspiracy: an introduction
This introduction offers an overview of current academic discussions about the term ‘conspiracy theory’, the historical development of conspiracy beliefs, and academic knowledge of the phenomenon. In addition, it addresses the relation between conspiracy thinking, state power, culture and deviance. The authors emphasize the need to move beyond a pathological view on conspiracy beliefs, to take them seriously and study them from a cultural and critical criminological perspective.