bluuebunny/crossref_metadata_2025_split huggingface dataset:
A neural network account of memory replay and knowledge consolidation
Authors: Barry Daniel N , Love Bradley C 
Published: January 2022

Abstract
Replay can consolidate memories through offline neural reactivation related to past experiences. Category knowledge is learned across multiple experiences, and its subsequent generalization is promoted by consolidation and replay during rest and sleep. However, aspects of replay are difficult to determine from neuroimaging studies. We provided insights into category knowledge replay by simulating these processes in a neural network which approximated the roles of the human ventral visual stream and hippocampus. Generative replay, akin to imagining new category instances, facilitated generalization to new experiences. Consolidation-related replay may therefore help to prepare us for the future as much as remember the past. Generative replay was more effective in later network layers functionally similar to the lateral occipital cortex than layers corresponding to early visual cortex, drawing a distinction between neural replay and its relevance to consolidation. Category replay was most beneficial for newly acquired knowledge, suggesting replay helps us adapt to changes in our environment. Finally, we present a novel mechanism for the observation that the brain selectively consolidates weaker information, namely a reinforcement learning process in which categories were replayed according to their contribution to network performance. This reinforces the idea of consolidation-related replay as an active rather than passive process.
Digital Strategy and Social Media for Infectious Diseases
Authors: Marcelin Jasmine R , del Rio Carlos , Spec Andrej , Swartz Talia H 
Published: January 2022

Abstract
This supplement demonstrates the profound reach of social media across several domains: improved clinical care and advocacy, data analysis, broad reach to diverse patient populations, educational access, best practices in medical education, peer review, digital strategy for individuals and institutions, and combating misinformation.
Predicting the Risk of Human Immunodeficiency Virus Type 1 (HIV-1) Acquisition in Rural South Africa Using Geospatial Data
Authors: Roberts D Allen , Cuadros Diego , Vandormael Alain , Gareta Dickman , Barnabas Ruanne V , Herbst Kobus , Tanser Frank , Akullian Adam 
Published: January 2022

Abstract

Background
Accurate human immunodeficiency virus (HIV) risk assessment can guide optimal HIV prevention. We evaluated the performance of risk prediction models incorporating geospatial measures.

Methods
We developed and validated HIV risk prediction models in a population-based cohort in South Africa. Individual-level covariates included demographic and sexual behavior measures, and geospatial covariates included community HIV prevalence and viral load estimates. We trained models on 2012–2015 data using LASSO Cox models and validated predictions in 2016–2019 data. We compared full models to simpler models restricted to only individual-level covariates or only age and geospatial covariates. We compared the spatial distribution of predicted risk to that of high incidence areas (≥ 3/100 person-years).

Results
Our analysis included 19 556 individuals contributing 44 871 person-years and 1308 seroconversions. Incidence among the highest predicted risk quintile using the full model was 6.6/100 person-years (women) and 2.8/100 person-years (men). Models using only age group and geospatial covariates had similar performance (women: AUROC = 0.65, men: AUROC = 0.71) to the full models (women: AUROC = 0.68, men: AUROC = 0.72). Geospatial models more accurately identified high incidence regions than individual-level models; 20% of the study area with the highest predicted risk accounted for 60% of the high incidence areas when using geospatial models but only 13% using models with only individual-level covariates.

Conclusions
Geospatial models with no individual measures other than age group predicted HIV risk nearly as well as models that included detailed behavioral data. Geospatial models may help guide HIV prevention efforts to individuals and geographic areas at highest risk.
Relating In Vitro Neutralization Level and Protection in the CVnCoV (CUREVAC) Trial
Authors: Cromer Deborah , Reynaldi Arnold , Steain Megan , Triccas James A , Davenport Miles P , Khoury David S 
Published: January 2022

Abstract
The vaccine candidate CVnCoV (CUREVAC) showed surprisingly low efficacy in a recent phase 3 trial compared with other messenger RNA (mRNA) vaccines. Here we show that the low efficacy follows from the dose used and the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and is predicted by the neutralizing antibody response induced by the vaccine.
The impact of a cause–effect elaboration procedure on information security risk perceptions: a construal fit perspective
Authors: Goh Zhang Hao , Hou Minzheng , Cho Hichang 
Published: January 2022

Abstract
Cybersecurity breaches are on the rise. Extant literature in the development of strategies to enhance IT users’ online protective behaviours has neglected users’ cognitive processing of cybersecurity risk information. This study demonstrates a cause–effect elaboration procedure based on the concept of construal fit to influence online users’ cybersecurity risk perceptions. Using online experiments (N = 534), the construal fit between elaboration of causes vs effects of cybersecurity risks and perceived temporal distance (distant vs near) was manipulated. The results revealed that a construal fit between the elaboration of ‘effects’ (vs ‘causes’) and temporally ‘near’ (vs ‘distant’) cybersecurity risks enhanced users’ risk perceptions, which in turn predicted protective behavioural intentions. Ensuring construal fit is a novel, cognition-based approach to safeguard IT users against online threats. Our findings enrich existing staged theories used to investigate cybersecurity risk perceptions and suggest to practitioners that heightened cyber risk perception can effectively be induced by simultaneously enhancing the concreteness of IT users’ construal of cybersecurity incidents and emphasizing on its negative consequences (vs causes).
Overcoming information-sharing challenges in cyber defence exercises
Authors: Brilingaitė Agnė , Bukauskas Linas , Juozapavičius Aušrius , Kutka Eduardas 
Published: January 2022

Abstract
Active usage of threat intelligence information supports effective prevention, mitigation and defence against cyberattacks by threat actors ranging from individual amateurs to state organizations. However, threat intelligence highly depends on security specialists’ ability to share incident data on threat information-sharing platforms. Unfortunately, business managers and educational institutions undervalue the information-sharing aspect when planning the professional development of cybersecurity-related specialists. Consequently, cybersecurity specialists are insufficiently motivated to correctly communicate and propagate relevant information with team members, superiors, relevant institutions and the global community about the impact of the incident. Literature review reveals many technological, legal and psychological obstacles hindering successful information exchange. This research aims to improve threat information sharing by focusing on the educational aspect of the problem and analysing the attitude of cybersecurity specialists during cyber defence exercises (CDX). Our case study disclosed nine factors obstructing both proper reporting to relevant authorities and adequate communication among teams. By addressing these factors, CDX organizers could substantially improve the development of highly beneficial soft skills of the technical specialists.
An enormous right atrial myxoma highlights the role of echocardiography in heart failure pathways: a case report
Authors: Straw Sam , Sengupta Anshuman , Gantenby V Kate , Schlosshan Dominik , Ferrara Antonella , Witte Klaus K 
Published: January 2022

Abstract

Background
Myxomata are rare, benign, primary tumours of the heart which can present with a variety of symptoms depending on size, location, and mobility. Here, we report a case of enormous right atrial myxoma, obliterating the right atrial and right ventricular cavities presenting with symptoms of heart failure.

Case summary
A 66-year-old Caucasian female presented to primary care with symptoms of right heart failure and was found to have elevated N-terminal pro B-type natriuretic peptide of 2829 ng/L (normal value &lt;125 ng/L). The patient was referred for urgent evaluation to the integrated heart failure service at our institution. Echocardiography revealed an enormous mobile mass attached to the right atrial septum, extending into the right ventricle and inferior vena cava measuring 90 × 42 mm. The patient underwent urgent surgical resection. Perioperative transoesophageal echocardiography demonstrated severe tricuspid regurgitation, which was treated with tricuspid annuloplasty ring. The patient made an uneventful recovery and was discharged. Subsequent imaging showed a reduction in right ventricular dimensions and improved systolic function.

Discussion
This case serves to remind us of the critical role of echocardiography in the diagnosis and management of people with breathlessness and raised natriuretic peptides. Therapies for heart failure are guided by ejection fraction, therefore timely and accurate diagnosis is critical. Moreover, as in this case, echocardiography can also identify other features of critical relevance to patient care.
Progression of aortic valve insufficiency during centrifugal versus axial flow left ventricular assist device support
Authors: Jimenez Contreras Fabian , Mendiola Pla Michelle , Schroder Jacob , Bryner Benjamin , Agarwal Richa , Russell Stuart D , Mirza Jacqueline , Daneshmand Mani A , Milano Carmelo 
Published: January 2022

Abstract

OBJECTIVES
Long-term left ventricular assist device (LVAD) support can cause accelerated progression of aortic insufficiency (AI). The MOMENTUM trial has led to increased use of the HeartMate 3 (HM3) LVAD, due to greater hemocompatibility. However, the differential effect on the rate of progression of AI during HM3 support versus HeartMate 2 (HM2) has not been extensively studied. This analysis compares the rates of progression to moderate or severe AI (MSAI) comparing a cohort of patients supported with the HM2 versus HM3.

METHODS
A retrospective review was performed on all consecutive patients implanted with HM2 or HM3 between May 2005 and June 2020. Follow-up time was limited to the first 6 years after LVAD implantation. Demographics and 4005 echocardiograms were assessed for 536 HM2 and 300 HM3 patients. The primary end point was progression to MSAI. Univariable and multivariable Cox proportional hazard regression and landmark analyses were performed.

RESULTS
Progression to MSAI was greater in the HM2 (17%) versus HM3 (9.9%) cohort. On the univariable analysis, the hazard ratio for HM3 was 0.581 (95% confidence interval 0.370–0.909, P = 0.02) whereas on multivariable analysis hazard ratio was 0.624 (95% confidence interval 0.386–1.008, P = 0.0537). Preoperative AI, female sex and body surface area &lt;2 were significantly associated with progression to MSAI. Landmark analysis suggests that LVAD type has the most significant effect on progression to MSAI between 1 and 2 years post-implantation.

CONCLUSIONS
Current practice strategies achieved low rates of progression to MSAI. Preoperative AI, female sex and body surface area &lt;2 were the most important predictors of progression to MSAI. Pump type appears to be of secondary importance.
Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction
Authors: Ryan Calen P , Jones Meaghan J , Edgar Rachel D , Lee Nanette R , Kobor Michael S , McDade Thomas W , Kuzawa Christopher W 
Published: January 2022

Abstract

Background
Consistent with evolutionarily theorized costs of reproduction (CoR), reproductive history in women is associated with life expectancy and susceptibility to certain cancers, autoimmune disorders and metabolic disease. Immunological changes originating during reproduction may help explain some of these relationships.

Methodology
To explore the potential role of the immune system in female CoR, we characterized leukocyte composition and regulatory processes using DNA methylation (DNAm) in a cross-sectional cohort of young (20–22 years old) women differing in reproductive status.

Results
Compared to nulliparity, pregnancy was characterized by differential methylation at 828 sites, 96% of which were hypomethylated and enriched for genes associated with T-cell activation, innate immunity, pre-eclampsia and neoplasia. Breastfeeding was associated with differential methylation at 1107 sites (71% hypermethylated), enriched for genes involved in metabolism, immune self-recognition and neurogenesis. There were no significant differences in DNAm between nulliparous and parous women. However, compared to nullipara, pregnant women had lower proportions of B, CD4T, CD8T and natural killer (NK) cells, and higher proportions of granulocytes and monocytes. Monocyte counts were lower and NK counts higher among breastfeeding women, and remained so among parous women.

Implications
Our findings point to widespread differences in DNAm during pregnancy and lactation. These effects appear largely transient, but may accumulate with gravidity become detectable as women age. Nulliparous and parous women differed in leukocyte composition, consistent with more persistent effects of reproduction on cell type. These findings support transient (leukocyte DNAm) and persistent (cell composition) changes associated with reproduction in women, illuminating potential pathways contributing to CoR.
Lay Summary: Evolutionary theory and epidemiology support costs of reproduction (CoR) to women’s health that may involve changes in immune function. We report differences in immune cell composition and gene regulation during pregnancy and breastfeeding. While many of these differences appear transient, immune cell composition may remain, suggesting mechanisms for female CoR.
A Stall Only on the Surface? Working Hours and the Persistence of the Gender Wage Gap in Western Germany 1985–2014
Authors: Schmitt Laila , Auspurg Katrin 
Published: January 2022

AbstractTo what extent has the closing of the gender gap in hourly wages (‘gender wage gap’; GWG) in Western Germany stalled due to an increasing supply of non-standard working hours? We use descriptive trend analyses and Juhn–Murphy–Pierce decompositions of German Socio-Economic Panel data for the last 30 years (1985–2014) to analyse the extent to which the expansion of part-time and marginal work, as well as overwork, may have contributed to the dynamics of the GWG in Western Germany. We find that the large increase in part-time work among women in combination with increasing wage gaps between part-time and full-time work substantially widened the GWG (by about one-sixth). Working hour effects were large enough to offset the equalizing effects of declining gender gaps in human capital, and they existed even in the public sector. In contrast to the United States, trends in overwork did not have a meaningful impact on the GWG. In an add-on, we find a widening of the gender gap in monthly earnings, but also an important closing of the gender earnings gap unconditional on employment due to an increased labour supply of women. Our results suggest that working hours should be given more consideration in research on family–work conflict and gender earnings inequalities.
What makes working together work? A scoping review of the guidance on North–South research partnerships
Authors: Voller Shirine , Schellenberg Joanna , Chi Primus , Thorogood Nicki 
Published: January 2022

Abstract
At their best, research partnerships provide a mechanism to optimize each partner’s strengths, make scientific discoveries and achieve development goals. Each partner stands to gain from the relationship and perceives it to be fair. However, partnerships between institutions in the global North and the global South have been beleaguered by structural inequalities and power imbalances, and Northern stakeholders have been criticized for perpetuating paternalistic or neo-colonial behaviours. As part of efforts to redress imbalances and achieve equity and mutual benefit, various principles, guidelines, frameworks and models for partnership have been developed. This scoping review maps the literature and summarizes key features of the guidelines for North–South research partnerships. The review was conducted between October 2020 and January 2021. Three academic journal databases and Google were searched, and additional resources were identified through a hand search of reference lists and expert recommendation. Twenty-two guidelines were identified published between 1994 and 2021 and originating predominantly in the fields of international development and global health. The themes addressed within the guidelines were aggregated using NVivo qualitative analysis software to code the content of each guideline. Topics featuring most prominently in the guidelines were: partner roles, responsibilities and ways of working; capacity strengthening; motivation and goals; resource contributions; agenda setting and study design; governance structures and institutional agreements; dissemination; respect for affected populations; data handling and ownership; funding and long-term commitments. The current study reinforces many of the themes from two recent scoping reviews specific to the field of global health, but gaps remain, which need to be addressed: Southern stakeholders continue to be under-represented in guideline development, and there is limited evidence of how guidelines are used in practice. Further exploration is needed of Southern stakeholder priorities and whether and how guidelines are operationalized.
Obesity and Cerebral Blood Flow in the Reward Circuitry of Youth With Bipolar Disorder
Authors: Grigorian Anahit , Kennedy Kody G , Luciw Nicholas J , MacIntosh Bradley J , Goldstein Benjamin I 
Published: January 2022

Abstract

Background
Bipolar disorder (BD) is associated with elevated body mass index (BMI) and increased rates of obesity. Obesity among individuals with BD is associated with more severe course of illness. Motivated by previous research on BD and BMI in youth as well as brain findings in the reward circuit, the current study investigates differences in cerebral blood flow (CBF) in youth BD with and without comorbid overweight/obesity (OW/OB).

Methods
Participants consisted of youth, ages 13–20 years, including BD with OW/OB (BDOW/OB; n = 25), BD with normal weight (BDNW; n = 55), and normal-weight healthy controls (HC; n = 61). High-resolution T1-weighted and pseudo-continuous arterial spin labeling images were acquired using 3 Tesla magnetic resonance imaging. CBF differences were assessed using both region of interest and whole-brain voxel-wise approaches.

Results
Voxel-wise analysis revealed significantly higher CBF in reward-associated regions in the BDNW group relative to the HC and BDOW/OB groups. CBF did not differ between the HC and BDOW/OB groups. There were no significant region of interest findings.

Conclusions
The current study identified distinct CBF levels relating to BMI in BD in the reward circuit, which may relate to underlying differences in cerebral metabolism, compensatory effects, and/or BD severity. Future neuroimaging studies are warranted to examine for changes in the CBF-OW/OB link over time and in relation to treatment.
A Separable Universal Homogeneous Banach Lattice
Authors: Angelica Tursi Mary 
Published: January 2022

Abstract
We prove the existence of a separable approximately ultra-homogeneous Banach lattice $\mathfrak {B}\mathfrak {L}$ that is isometrically universal for separable Banach lattices. This is done by showing that that the class of finitely generated Banach lattices has the Amalgamation Property and thus form a metric Fraïssé class. Some additional results about the structural properties of $\mathfrak { BL}$ are also proven.
Serum Vitamin D Levels and Life-Threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants
Authors: Ferolla F Martin , Yfran E Walter , Ballerini M Gabriela , Caratozzolo Ana , Toledano Analía , Giordano Ana C , Acosta Patricio L , Cassinelli Hamilton , Bergada Ignacio , Ropelato M Gabriela , Contrini María M , López Eduardo L ,   GUTI Respiratory Infections Network, Neira Pablo , Carrizo Bárbara , Chiormi Agustina , Visingardi Gabriela , Feldman Florencia , Reyero Mariana , Talarico Laura , Retta Alejandra , Matute Javier , Mascardi Normando 
Published: January 2022

Abstract

Background
25-hydroxyvitamin D (VD) effects on lung function and immune-modulation might affect respiratory syncytial virus (RSV) infection outcomes. We aimed to assess VD levels on admission and their association with life-threatening RSV disease (LTD).

Methods
A prospective cohort study was conducted during 2017–2019. Previously healthy infants aged &lt;12 months, hospitalized with a first episode of RSV infection, were enrolled. LTD was defined by need for intensive care and ventilatory support. Serum VD levels &lt;20 ng/mL were categorized as deficient, and 20–29.9 ng/mL as insufficient.

Results
Of 125 patients studied, 73 (58%) were male. Median age was 4 months. Twenty-two patients developed LTD. No differences in viral load were seen between cases with LTD and controls (P = .94). Patients who developed LTD had significantly lower VD levels: median 18.4 ng/mL (IQR, 15.1–26.9 ng/mL) versus 31.7 ng/mL (IQR, 23.6–42.0 ng/mL), P &lt; .001; 59% of infants with LTD had VD deficiency compared with 12% in those with better outcome. Multivariable regression analysis confirmed VD deficiency as a risk factor (odds ratio, 11.83; 95% confidence interval, 3.89–35.9; P &lt; .001).

Conclusions
These findings provide additional evidence for the development of strategies to prevent severe RSV infections.
Spectrum of Activity of Raltegravir and Dolutegravir Against Novel Treatment-Associated Mutations in HIV-2 Integrase: A Phenotypic Analysis Using an Expanded Panel of Site-Directed Mutants
Authors: Smith Robert A , Wu Vincent H , Song Jennifer , Raugi Dana N , Diallo Mbaye Khardiata , Seydi Moussa , Gottlieb Geoffrey S 
Published: January 2022

Abstract

Background
Integrase inhibitors (INIs) are a key component of antiretroviral therapy for human immunodeficiency virus-1 (HIV-1) and HIV-2 infection. Although INI resistance pathways are well-defined for HIV-1, mutations that emerge in HIV-2 in response to INIs are incompletely characterized.

Methods
We performed systematic searches of GenBank and HIV-2 drug resistance literature to identify treatment-associated mutations for phenotypic evaluation. We then constructed a library of 95 mutants of HIV-2ROD9 that contained single or multiple amino acid changes in the integrase protein. Each variant was tested for susceptibility to raltegravir and dolutegravir using a single-cycle indicator cell assay.

Results
We observed extensive cross-resistance between raltegravir and dolutegravir in HIV-2ROD9. HIV-2–specific integrase mutations Q91R, E92A, A153G, and H157Q/S, which have not been previously characterized, significantly increased the half maximum effective concentration (EC50) for raltegravir when introduced into 1 or more mutational backgrounds; mutations E92A/Q, T97A, and G140A/S conferred similar enhancements of dolutegravir resistance. HIV-2ROD9 variants encoding G118R alone, or insertions of residues SREGK or SREGR at position 231, were resistant to both INIs.

Conclusions
Our analysis demonstrates the contributions of novel INI-associated mutations to raltegravir and dolutegravir resistance in HIV-2. These findings should help to improve algorithms for genotypic drug resistance testing in HIV-2–infected individuals.