bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quick Release of Hydrogen Peroxide from Carbamide Peroxide Promotes Apoptosis of A549 Lung Cancer Cells
Authors: Meng Xiangrui , Zheng Qiao , Sun Yuanyuan , Wang Qian , Wang Lan , Yuan Ping , Song Xiao , Miao Yuqing 
Published: August 2022

AbstractLung cancer is one of the malignant tumors with the leading morbidity and mortality worldwide. H2O2 is an important oxidant, and lethal to tumor cells. The present study aimed to explore new higher‐H2O2‐content and faster‐H2O2‐release rate carbamide peroxide (CP) compounds for treatment of lung cancer. The CP added with benzoic acid termed CP−B was applied in the research. Fenton reaction was used to determine the content and rate of H2O2 release by degrading organic small molecule dyes. The results showed that CP−B could be decolorized 200 mg/L RhB solution within 60 s. The phenotype was analyzed by vitro experiment the effects of the CP compound on A549 lung cancer cell line. The results showed that CP−B had a significant effect on pro‐apoptosis, anti‐proliferation and anti‐migration of A549 cells. Using RNA seq, it was found that CP−B might up‐regulate the INS‐IGF2 gene and it was closely related to the PI3 K/AKT signaling pathway. Finally, in vivo experiments indicated that CP−B has extremely low side effects and potentially tumor treatment capabilities.
Room Temperature Direct Reductive Amination of Carbonyl compounds by L‐ascorbic Acid‐ NaBH4 in Water
Authors: Mukherjee Suvodip , Chandra Pariyar Gyan , Mitra Bijeta , Ghosh Pranab 
Published: August 2022

AbstractA novel concept for the direct reductive amination of aldehyde and ketones has been developed which uses largely available, low cost and harmless L‐ascorbic acid as sustainable, versatile, non‐toxic catalyst and NaBH4 as a reductant. Described herein is a one‐pot conversion of effortlessly accessible primary and secondary amines to biologically active secondary and tertiary amines respectively in water at room temperature within 15–45 minutes. The generality of reaction was established by using various aromatic and aliphatic aldehydes, ketones and amines with 20 examples ranging from 65 to 97 % yield. The mild condition, environmentally benign byproducts and broad scope of makes this transformation very useful.
Distal renal tubular acidosis and lethargy associated with zonisamide treatment in a dog with idiopathic epilepsy
Authors: Itoi Takamasa , Akashi Natsuki , Shimizu Yuki , Sugimoto Keisuke , Hata Akihisa , Kutara Kenji , Miyama Takako Shimokawa , Kanda Teppei 
Published: August 2022

AbstractA 3‐year‐old neutered male golden retriever administered zonisamide for the treatment of seizures showed lethargy and had normal anion gap metabolic acidosis with hypokalaemia, hyperchloremia, and alkaline urine. The serum zonisamide concentration was close to the upper limit, which raised a suspicion of adverse effects of zonisamide. This is the first report showing that the fractional excretion of bicarbonate after compensation for the plasma bicarbonate concentration by a sodium bicarbonate infusion was approximately 5%, indicating distal renal tubular acidosis (RTA). The serum zonisamide concentration decreased, and adverse effects were abated by reducing the zonisamide dosage. Diagnostic therapy with bicarbonate served as a means of compensating for bicarbonate deficiency and contributed to the clinical diagnosis of the condition in zonisamide‐associated RTA in dogs.
Suicide in the Transport System
Authors: Andersson Anna-Lena , Svensson Kenneth 
Published: August 2022

AbstractThe Swedish Transport Administration (STA) work to reduce the number of suicides in the transport system. Fatalities, i.e., on roads, railways, and bridges, originate from either accidents or suicides, natural death excluded. Knowing the correct manner of death is needed to work with optimal prevention strategies. The aims are to separate fatalities due to suicides, follow the development, and implement measures for suicide prevention. Methods are developed for suicide classification and criteria for the selection in which suicides were suspected. Fatalities in level one and two of five were classified as suicides. Data from the STA’s databases are used and so are data from the psychosocial investigations done by a trained investigator in the topic and with clinical experience from counselling at hospitals. 2129 persons died on the roads in Sweden, 10% (206 persons) were classified as suicides. 336 persons died after being hit by trains, 85% (284 persons) were suicides. 130 persons died by jumping from bridges.The number of suicides increases with population density. Suicide in the transport system is a major problem; firstly personal tragedies, it is also a work environment problem for truck and train drivers and for the emergency staff. It generates delays and costs for passenger and cargo transport. By analyzing the results of countermeasures in the form of obstructive barriers, the physical environment can be improved and high-risk areas can be accentuated. Restricting access to the means of suicide is important in suicide prevention. Strategies for the STA include suicide prevention in the design of new roads, railways, and bridges, as well as by identifying and reducing existing high-risk locations. Sharing the results with other authorities and organizations and cooperation within suicide prevention missions are vital for the enhancement of the overall suicide prevention work in society.
Classification of Robinson-Trautman and Kundt geometries with Large D limit
Authors: Kirezli Pınar 
Published: August 2022

Abstract
Algebraic classification of higher dimensional, shear-free, twist-free, expanding (or non-expanding) spacetime is studied with the limit of D → ∞. Similar to classification of any arbitrary dimension D > 4, this spacetime is Type I(b) or more special, according to our calculations. However, thanks to the method of taking the limit of dimension D → ∞, the relevant Weyl scalars become much simpler. Without solving field equations, by determining obligatory conditions to the components of Weyl scalar vanish, the spacetime is classified Type I(a), Type II(a-b-c-d), Type III(a-b), Type N and Type O for primary Weyl aligned null direciton (WAND), and Type Ii, Type IIi, Type IIIi and Type D(a-b-c-d) for secondary WAND.
Treatment patterns and prognosis of patients with inoperable stage III NSCLC after completion of concurrent chemoradiotherapy ± immune checkpoint inhibition: a decade-long single-center historical analysis
Authors: Flörsch Benedikt , Taugner Julian , Käsmann Lukas , Kenndoff Saskia , Guggenberger Julian , Tufman Amanda , Reinmuth Niels , Duell Thomas , Belka Claus , Eze Chukwuka , Manapov Farkhad 
Published: August 2022

Abstract
Purpose
To investigate the impact of treatment time and patterns in inoperable stage III non-small cell lung cancer (NSCLC) following concurrent chemoradiotherapy (cCRT) ± immune checkpoint inhibitors (ICIs).

Methods
Patients were stratified by treatment year: A (2011–2014), B (2015–2017) and C (2018–2020). Tumor- and treatment-related characteristics regarding locoregional recurrence-free survival (LRRFS), progression-free survival (PFS) and overall survival (OS) were investigated.

Results
One hundred and thirty-six consecutive patients were analyzed. All patients completed thoracic radiotherapy (TRT) to a total dose ≥ 60.0 Gy; 36 (26%) patients received ICI. Median PFS in subgroups A, B and C was 8.0, 8.2 and 26.3 months (p = 0.007). Median OS was 19.9 months, 23.4 months and not reached (NR), respectively. In group C, median LRRFS and PFS were 27.2 vs. NR; and 14.2 vs. 26.3 months in patients treated with and without ICI. On multivariate analysis planning target volume (PTV) ≥ 700 cc was a negative prognosticator of LRRFS (HR 2.194; p = 0.001), PFS (HR 1.522; p = 0.042) and OS (HR 2.883; p = 0.001); ICI was a predictor of LRRFS (HR 0.497; p = 0.062), PFS (HR 0.571; p = 0.071) and OS (HR 0.447; p = 0.1). In the non-ICI cohort, multivariate analyses revealed PTV ≥ 700 cc (p = 0.047) and a maximum standardized uptake value (SUVmax) ≥ 13.75 (p = 0.012) were predictors of PFS; PTV ≥ 700 cc (p = 0.017), SUVmax ≥ 13.75 (p = 0.002) and a total lung V20 ≥ 30% (V20 ≥ 30) (p < 0.05) were predictors of OS.

Conclusions
Patients treated after 2018 had improved survival regardless of ICI use. Implementation of ICI resulted in further significant increase of all tested survival endpoints. PTV ≥ 700 cc and ICI were only prognosticators for LRRFS, PFS and OS in the analyzed cohort.
Spatial genetic structure in the Madeiran endemic Dactylorhiza foliosa (Orchidaceae)
Authors: Hedren Mikael 
Published: August 2022

AbstractOceanic islands have isolated biota, which typically include many endemic species. However, island endemics are vulnerable due to small population sizes, and they are often threatened by habitat destruction or by introduced pests and predators. Adequate conservation planning requires good information on genetic variability and population structure, also when seemingly viable species are considered. Here, I analysed the genetic structure in the terrestrial orchid Dactylorhiza foliosa, which is endemic to Madeira. This species is a characteristic component of evergreen laurel forests occupying the northern slopes of the island. Levels of diversity in both the plastid genome and in the nuclear genome were comparable to levels of diversity found in congeners growing in continental regions. Within populations, plants separated by distances up to 256 m shared plastid haplotypes significantly more often than plants at random, but when nuclear markers were considered, only plants growing closer than eight metres were significantly more closely related. Analysis of plastid marker variation revealed that gene dispersal by seeds is not sufficiently large to counterbalance the accumulation of mutations that build up divergence between the most distant populations. However, differentiation in the nuclear genome was considerably smaller, suggesting that gene dispersal by pollen is much more efficient than gene dispersal by seeds in D. foliosa. The overall pollen to seed dispersal ratio, mp/ms, was 7.30. Considering genetic parameters, conditions for long-term persistence of D. foliosa on Madeira seem to be good.
A material momentum balance law for shells and plates with application to phase transformations and adhesion
Authors: Goldberg Nathaniel N. , O’Reilly Oliver M. 
Published: August 2022

AbstractA balance law for material momentum in shells and plates is proposed. The implications of this balance law for the propagation of defects, phase transformations, and shocks are explored. The developments are presented using a purely mechanical theory of a Cosserat (or directed) shell and specialized to the cases of a Kirchhoff–Love shell theory and a linearly elastic plate theory. To explore connections to the literature on delamination and adhesion, the balance law is applied to the problem of blistering.
Age Effects on Women’s and Men’s Dyadic and Solitary Sexual Desire
Authors: Wieczorek Larissa L. , Chivers Meredith , Koehn Monica A. , DeBruine Lisa M. , Jones Benedict C. 
Published: August 2022

AbstractWhile most studies on sexuality in later life report that sexual desire declines with age, little is known about the exact nature of age effects on sexual desire. Using self-reported dyadic sexual desire relating to a partner, dyadic sexual desire relating to an attractive person, and solitary sexual desire from a large (N > 8000) and age diverse (14.6–80.2 years) online sample, the current study had three goals: First, we investigated relationships between men and women’s sexual desire and age. Second, we examined whether individual differences such as gender/sex, sexual orientation, self-rated masculinity, relationship status, self-rated attractiveness, and self-rated health predict sexual desire. Third, we examined how these associations differed across sexual desire facets. On average, the associations between age and both men and women’s sexual desire followed nonlinear trends and differed between genders/sexes and types of sexual desire. Average levels of all types of sexual desire were generally higher in men. Dyadic sexual desire related positively to self-rated masculinity and having a romantic partner and solitary desire was higher in people with same-sex attraction. We discuss the results in the context of the evolutionary hypothesis that predict an increase of sexual desire and female reproductive effort prior to declining fertility. Our findings both support and challenge beliefs about gender/sex specificity of age effects on sexual desire and highlight the importance of differentiating between desire types.
Supporting English non-dominant language authors’ efforts to publish: perspectives from the editors-in-chief of highly recognised journals in Mathematics Education
Authors: Geiger Vince , Delzoppo Catherine , Straesser Rudolf 
Published: August 2022

AbstractIn this article, we document the support provided by highly recognised journals in Mathematics Education in response to the challenges faced by English non-dominant language (EnDL) authors when they attempt to publish in English. To address this issue, we first conducted a synthesis of research literature related to those influences that direct EnDL authors’ publication efforts towards English language journals and the associated challenges that result. Second, we gathered survey and interview data from participant editors-in-chief of leading journals in Mathematics Education about the support, enacted and planned, provided by their journal for EnDL authors and associated challenges. Finally, we discuss the findings of the study from the perspective of heteroglossia. Findings indicate that while a range of initiatives have been employed to support EnDL authors, current journal policies lag somewhat behind the plans of editors-in-chief, which have been limited, to date, by available resources.
Assessment of the diet-environment-health-cost quadrilemma in public school canteens. an LCA case study in Galicia (Spain)
Authors: Simon Xavier , Copena Damián , Pérez-Neira David 
Published: August 2022

AbstractThe role of policies and public school canteens as drivers of sustainable and healthy diets is increasingly becoming the center of attention of academics and policy-makers alike. This work therefore aims to assess the environmental, economic and nutritional quality dimensions of the menus consumed across the Local Network of School Canteens in the municipality of Ames (Galicia, Spain). It additionally performs different scenarios to evaluate the effects on the environment-cost-nutritional quality trilemma of implementing two major dietary changes in these menus: introducing more organic products, and shifting toward a more plant-based consumption pattern. To this end, this study considers the following indicators: a) those obtained from an energy and carbon life cycle assessment of the school menus (cradle-to-grave approach), mainly the cumulative energy demand (CED) and the carbon footprint (CF), complemented by some energy efficiency indicators; b) the total cost (TC) of the menus, obtained from their life cycle cost assessment (cradle-to-fork approach); and c) the nutritional quality of the menus, calculated and assessed based on the nutrient rich diet index (NRD 9.3). The CED, CF, TC, and NRD 9.3 index of a daily meal at school canteens are, respectively, estimated at 18.87 MJ, 1.30 kg CO2-eq, EUR 4.65, and 278 per meal. The consumption of animal products and labor (for food preparation) are identified, respectively, as the main environmental impact and economic cost of the menus. The results of our research show how implementing changes in consumption habits toward a more vegetarian diet in school menus makes it possible to include organic products to generate the most positive effects in terms of the environment and nutrition without incurring in cost overruns. Our work discusses the main barriers to be overcome and the political actions that must be enforced to advance the procurement of more sustainable and healthy public food.
Graphical abstract
Higher education and the importance of values: evidence from the World Values Survey
Authors: Koshy Paul , Cabalu Helen , Valencia Vicar 
Published: August 2022

AbstractThe collection of data on values through instruments such as the World Values Survey has focused attention on two opposing but inter-related trends, namely the combination of substantial cultural change in many countries and the persistence of distinctive traditional values. This reflects the interplay between social changes associated with modernisation and globalisation—including increased global trade and the rise of global popular culture—with traditional values country-specific systems. In this paper, we introduce a focus on another potentially important source of change, that of widening higher education participation and attainment, and the extent to which self-reported values differ between university graduates and non-graduates. We investigated this question using data from the most recent collection of the World Values Survey (2017–2020) for six core values—family, friends, leisure, work, politics, and religion—and tested for the influence of higher education attainment on the perceived “importance” of each value and the extent to which this influence differs across values and in gender, generation and country grouping sub-samples. We find evidence for consistent effects in most contexts, with no statistical differences between graduates on non-graduates in relation to the propensity to view family and work as important, statistically significant positive effects on the propensity of graduates to view friends, leisure, and politics as important, and a significant negative effect in relation to religion.
It runs in the family?
Authors: Helin Jouni , Jokinen Juho , Koerselman Kristian , Nokkala Terhi , Räikkönen Eija 
Published: August 2022

AbstractFamily background has been shown to be a strong determinant of educational attainment, yet relatively little is known about the role that family background plays in PhD attainment or in the selection into academic careers. In this study, we estimate sibling correlations from Finnish full population register data to comprehensively assess the importance of family background in selection into academia. Our results show that family background accounts for over a third of the overall variation in becoming a PhD and subsequently an academic — a share which is up to four times as large as implied by conventional comparisons by parental education. However, we did not find evidence that family background would be an exceptionally strong determinant of doctoral outcomes when compared to other educational outcomes. Our findings further suggest that sibling similarities in PhD attainment and academic careers may largely be attributed to sibling similarities in prior educational achievement rather than to other family background characteristics.
School Social Capital Mediates Associations Between ASD Traits and Depression Among Adolescents in General Population
Authors: Mori Hiroyuki , Hirota Tomoya , Monden Rei , Takahashi Michio , Adachi Masaki , Nakamura Kazuhiko 
Published: August 2022

AbstractThough autism spectrum disorder (ASD) traits are associated with depression, it is unclear if school social capital mediates their association. We examined whether school social capital mediates the association between ASD traits and depression, and moderation effect of sex on the mediation effect among adolescents in a general population sample (1750 males, 1779 females; equivalent 12–15 years old). The results of this study indicate that ASD traits are associated with depression among adolescents, and that this association is partly mediated by school social capital. Furthermore, the results of the moderated mediation analysis suggest that lower level of school social capital can lead to more increase level of depression for females than for males.
Was There a 3.2 ka Crisis in Europe? A Critical Comparison of Climatic, Environmental, and Archaeological Evidence for Radical Change during the Bronze Age–Iron Age Transition
Authors: Molloy Barry 
Published: August 2022

AbstractThe globalizing connections that defined the European Bronze Age in the second millennium BC either ended or abruptly changed in the decades around 1200 BC. The impact of climate change at 3.2 ka on such social changes has been debated for the eastern Mediterranean. This paper extends this enquiry of shifting human–climate relationships during the later Bronze Age into Europe for the first time. There, climate data indicate that significant shifts occurred in hydroclimate and temperatures in various parts of Europe ca. 3.2 ka. To test potential societal impacts, I review and evaluate archaeological data from Ireland and Britain, the Nordic area, the Carpathian Basin, the Po Valley, and the Aegean region in parallel with paleoclimate data. I argue that 1200 BC was a turning point for many societies in Europe and that climate played an important role in shaping this. Although long-term trajectories of sociopolitical systems were paramount in defining how and when specific societies changed, climate change acted as a force multiplier that undermined societal resilience in the wake of initial social disjunctures. In this way, it shaped, often detrimentally, the reconfiguration of societies. By impacting more directly on social venues of political recovery, realignment, and reorganization, climate forces accentuate societal crises and, in some areas, sustained them to the point of sociopolitical collapse.
Low-Cost Industrial IoT System for Wireless Monitoring of Electric Motors Condition
Authors: Magadán L. , Suárez F.J. , Granda J. C. , García D. F. 
Published: August 2022

AbstractCondition monitoring of industrial equipment has become a critical aspect in Industry 4.0. This paper shows the design, implementation and testing of a low-cost Industrial Internet of Things (IIoT) system designed to monitor electric motors in real-time. This system can be used to detect operating anomalies and paves the way for building predictive maintenance models. The system is built using low-cost hardware components (wireless multi-sensor modules and single-board computers as gateways), open-source software and open cloud services, where all the relevant information is stored. The module collects real-time vibration data from electric motors. Vibration analyses in the temporal and frequency domains were carried out in both modules and gateways to compare their capabilities. This approach is also a springboard to using edge/fog computing to save cloud resources. A system prototype has been tested in the laboratory and in an industrial dairy plant. The results show that the proposed system can be used for continuous monitoring of any rotatory machine with similar accuracy to professional monitoring devices but at a significantly lower cost.