bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-17 and TNF-β: Predictive biomarkers for transition to psychosis in ultra-high risk individuals
Authors: Ouyang Lijun , Li David , Li Zongchang , Ma Xiaoqian , Yuan Liu , Fan Lejia , Yang Zihao , Zhang Zhenmei , Li Chunwang , He Ying , Chen Xiaogang 
Published: December 2022

BackgroundDysregulation of immunity, such as levels of inflammatory factors, has been regarded as a sign of schizophrenia. Changes in cytokine levels are not only described in the early onset of disease, but also observed in ultra-high risk (UHR) individuals. This study aimed to investigate the potential of cytokines as biomarkers for psychotic disorders and in individuals at UHR of developing a psychotic disorder in the future.MethodsThe Luminex liquid chip technology was used to detect the concentrations of Interferon-gamma (INF-γ), Interleukin (IL)-2, Interleukin (IL)-4, Interleukin (IL)-6, Interleukin (IL)-17, Interleukin-1beta (IL-1β), and Tumor Necrosis Factor-beta (TNF-β) in the plasma of all subjects. Meanwhile, the plasma level of Tumor Necrosis Factor-Alpha (TNF-α) was measured with the enzyme-linked immunosorbent assay (ELISA) kits. Then, the levels of these cytokines were compared among patients with Drug-naïve first-episode schizophrenia (FES; n = 40), UHR population (UHR; n = 49), and healthy controls (HCs; n = 30). Baseline cytokine levels were compared among UHR individuals who later transitioned (UHR-T; n = 14), those who did not transition (UHR-NT; n = 35), and HCs (n = 30).ResultsOur analysis results showed that IL-1β levels were significantly higher in UHR group than HC group (p = 0.015). Meanwhile, TNF-α concentration was significantly increased in FES group compared with HC group (p = 0.027). IL-17 (p = 0.04) and TNF-β (p = 0.008) levels were significantly higher in UHR-T group compared with UHR-NT group.ConclusionIn conclusion, our findings suggest that the immuno-inflammatory activation level is increased in the early stage of psychosis before psychotic conversion and the Drug-naïve FES. IL-1β and TNF-α are the representatives of the specific biomarkers for UHR and FES, respectively. IL-17 and TNF-β may be the potential selective predictive biomarkers for future transition in UHR individuals.
META analysis on the effect of taijiquan on improving negative psychological symptoms of college students and the optimal dose
Authors: Du Zhihao , Zhang Xiuli , Qin Hao , Wang Ruiqi , Bai Yunxia , Yao Xiaonan 
Published: December 2022

BackgroundTaijiquan, as a physical and mental exercise, can improve the negative psychology of college students. However, it is still controversial, and the optimal exercise dose of taijiquan to interfere with negative psychology has not been evaluated.ObjectiveThis study is aimed at systematically evaluating the effect of taijiquan therapy on improving negative psychological symptoms of college students and its optimal intervention dose.MethodsSearch databases such as Web of Science, Embase, PubMed, CNKI, WFSD, etc. Collect high-quality relevant RCT studies. After screening, extracting, coding and counting the data, a META analysis is done through Review Manage 5.3 and Stata 15.0 software. PICOS established the eligibility criteria to select the studies as follows: (i) population - non-clinical of college students; (ii) intervention - taijiquan intervention; (iii) comparison - taijiquan intervention group and regular physical activity group; (iv) outcomes - depression, anxiety; and (v) study design - randomized controlled trial.ResultsA total of 12 articles and 1,000 samples were included. All of the participants are college students. Taijiquan therapy can significantly reduce the depression and anxiety symptoms of college students [SMD = −0.53, 95% CI (−0.82, −0.23)], [SMD = −0.49, 95% CI (−0.90, −0.09)], with statistical significance (P &lt; 0.05). Subgroup analysis shows that: there is a precise focus on depression and anxiety symptoms. The intervention period is more than 12 weeks, and the best effect appears when people practice 3 times a week. The best single intervention time for depression symptoms is 60 min, and for anxiety symptoms 80–90 min. It is found that taijiquan combined with mindfulness intervention can significantly reduce negative psychological symptoms like depression and anxiety of college students than single taijiquan intervention. Funnel plot combined with sensitivity analysis, Begg, Egger test showed no publication bias.ConclusionTaijiquan intervention can effectively improve the negative psychological symptoms of college students, and it has great promotion value in colleges and universities.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022314071.
Prevalence and potential risk factors of self-reported diabetes among elderly people in China: A national cross-sectional study of 224,142 adults
Authors: Hu Xing , Meng Lingbing , Wei Zhimin , Xu Hongxuan , Li Jianyi , Li Yingying , Jia Na , Li Hui , Qi Xin , Zeng Xuezhai , Zhang Qiuxia , Li Juan , Liu Deping 
Published: December 2022

AimTo evaluated the prevalence and potential risk factors of self-reported diabetes among the elderly in China, by demographic data, socioeconomic factors, and psychological factors.MethodsDescriptive analysis and Chi-square analysis were used to assess the prevalence and variation between self-reported diabetes and non-diabetes by demographic data, living habits, socioeconomic factors and comorbidities. Univariate and multivariate logistic regression were used to describe the odds ratios (OR) of diabetes prevalence in different groups, while stratification analysis was performed to describe prevalence based on gender, age, and urban/rural areas.Results215,041 elderly adults (102,692 males and 112,349 females) were eventually included in the analysis. The prevalence of self-reported diabetes among the elderly in China is about 8.7%, with the highest prevalence in Beijing (20.8%) and the lowest prevalence in Xizang (0.9%). Logistic regression analysis showed that urban area (P &lt; 0.001), older age (65–84 years old, P &lt; 0.001), female (P &lt; 0.001), higher income(P &lt; 0.001), poor sleep quality (P = 0.01) and some other factors were potential risk factors for diabetes.ConclusionsThis study illustrates the prevalence and potential risk factors of diabetes among the elderly in China Meanwhile, these results provide information to assist the government in controlling non-communicable diseases in the elderly.
Estimating cropland requirements for global food system scenario modeling
Authors: Smith Nick W. , Fletcher Andrew J. , Millard Peter , Hill Jeremy P. , McNabb Warren C. 
Published: December 2022

IntroductionThe production of plant crops is foundational to the global food system. With the need for this system to become more sustainable while feeding an increasing global population, tools to investigate future food system scenarios can be useful to aid decision making, but are often limited to a calorie- or protein-centric view of human nutrition.MethodsHere, a mathematical model for forecasting the future cropland requirement to produce a given quantity of crop mass is presented in conjunction with the DELTA Model®: an existing food system scenario model calculating global availability of 29 nutrients against human requirements. The model uses national crop yield data to assign yield metrics for 137 crops.ResultsThe crops with the greatest variation between high and low yielding production were specific nuts, fruits, and vegetables of minor significance to global nutrient availability. The nut crop group showed the greatest overall yield variation between countries, and thus the greatest uncertainty when forecasting the cropland requirement for future increases in production. Sugar crops showed the least overall yield variation. The greatest potential for increasing global food production by improving poor yielding production was found for the most widely grown crops: maize, wheat, and rice, which were also demonstrated to be of high nutritional significance.DiscussionThe combined cropland and nutrient availability model allowed the contribution of plant production to global nutrition to be quantified, and the cropland requirement of future food production scenarios to be estimated. The unified cropland estimation and nutrient availability model presented here is an intuitive and broadly applicable tool for use in global food system scenario modeling. It should benefit future research and policy making by demonstrating the implications for human nutrition of changes to crop production, and conversely the implications for cropland requirement of food production scenarios aimed at improving nutrition.
Chemoradiotherapy with 3-weekly CDDP 80 mg/m2 for head and neck squamous cell carcinoma: 5-year survival data from a phase 2 study
Authors: Otaki Kohei , Takahashi Takeshi , Tanaka Ryoko , Saijo Kohei , Omata Jo , Yokoyama Yusuke , Shodo Ryusuke , Ueki Yushi , Yamazaki Keisuke , Ota Hisayuki , Togashi Takafumi , Takahashi Nao , Okabe Ryuichi , Matsuyama Hiroshi , Horii Arata 
Published: December 2022

ObjectiveThe global standard for chemoradiation therapy (CCRT) for head and neck squamous cell carcinoma is cisplatin 100 mg/m2 administered once every three weeks, although cisplatin 80 mg/m2 is also widely used as an alternative treatment to reduce adverse events in Japan. We aimed to assess the long-term survival outcomes and late adverse events associated with CCRT with a 3-weekly cisplatin dose of 80 mg/m2.MethodsA phase 2 study on CCRT with a 3-weekly cisplatin dose of 80 mg/m2 was performed in 47 patients between April 2015 and December 2016 at four centers in Japan. Survival outcomes and late adverse events at 5 years after this phase 2 trial were investigated.ResultsThe median follow-up period was 61 months. The 5-year progression-free survival/overall survival of all 47 patients was 66.0%/76.6%, while that of patients with stage III, IV disease (UICC) was 65.6%/71.9%. Seventeen patients (36%) experienced dysphagia as a late adverse event. Univariate and multivariate analyses revealed a significant association between acute mucositis/low body mass index (BMI) during CCRT and late dysphagia.ConclusionThe survival outcomes of CCRT with a 3-weekly cisplatin dose of 80 mg/m2 may be comparable to the previously reported dose of 100 mg/m2. Acute mucositis and low BMI at CCRT were risk factors for late dysphagia, indicating the importance of managing these conditions during CCRT to prevent late adverse events. Caution and care for acute mucositis and swallowing training in patients with low BMI may be important for preventing late-stage dysphagia.
Spontaneous regression of multiple flow-related aneurysms following treatment of an associated brain arteriovenous malformation: A case report
Authors: Andereggen Lukas , Gruber Philipp , Anon Javier , Tortora Angelo , Steiger Hans-Jakob , Schubert Gerrit A. , Marbacher Serge , Remonda Luca 
Published: December 2022

IntroductionThere is no consensus in the treatment strategy of intracranial aneurysms (IAs) associated with brain arteriovenous malformation (BAVM). In particular, it is unknown if a more aggressive approach should be considered in patients harboring a BAVM, in whom multiple aneurysms or a history of aneurysmal subarachnoid hemorrhage (aSAH) is present.Case presentationWe report on an elderly woman harboring multiple aneurysms with a history of SAH due to rupture of an unrelated IA. On evaluation, she was also found to harbor a contralateral, left parietal convexity BAVM. Following resection of the latter, spontaneous regression of two large flow-related aneurysms was encountered.DiscussionWe discuss the therapeutic decision-making, risk stratification, and functional outcome in this patient with regard to the pertinent literature on the risk of hemorrhage in IAs associated with BAVM.
Hyperbaric oxygen exposure alleviate metabolic side-effects of olanzapine treatment and is associated with Langerhans islet proliferation in rats
Authors: AlQudah Mohammad , Khalifeh Mohammad , Al-Azaizeh Rasha , Masaadeh Amr , Al-Rusan Omar M. , Haddad Husam K. 
Published: December 2022

Introduction: Olanzapine (OLZ) is one of the second-generation antipsychotics drugs (APDs) used to treat several psychiatric illnesses. Olanzapine treatment is often associated with many metabolic side effects in a dose dependent manner such as obesity, dyslipidemia and insulin resistance, induction of type II diabetes and acute pancreatitis in some patients.Methods: Hyperbaric Oxygen therapy (HBOT) was investigated as a tool to mitigate olanzapine metabolic side effects in rats. Thirty-six female Sprague Dawley (SD) rats were divided into 4 groups; rats on olanzapine treatment either exposed to hyperbaric oxygen therapy (HBOOLZ) or left without exposure (OLZ) then non-treated rats that either exposed to hyperbaric oxygen therapy or left without exposure (control). Rats received Hyperbaric Oxygen therapy for 35 days at 2.4 atmospheres absolute (ATA) for 2.5 h daily followed by intraperitoneal injection of olanzapine at 10 mg/kg or placebo.Results: Rats on either hyperbaric oxygen therapy or olanzapine had a significant loss in body weight. Olanzapine treatment showed a decrease in serum insulin level, triglyceride, highdensity lipoprotein (HDL) cholesterol, and lipase level but an increase in fasting blood sugar (FBS), insulin resistance index (HOMA-IR) and amylase, while rats’ exposure to hyperbaric oxygen therapy reversed these effects. The Pancreatic Langerhans islets were up-regulated in both hyperbaric oxygen therapy and olanzapine treatments but the combination (HBOOLZ) doubled these islets number.Discussion: This study advocated that hyperbaric oxygen therapy can be an alternative approach to control or reverse many metabolic disorders (MDs) associatedwith olanzapine treatment. In addition, it seems that hyperbaric oxygen therapy positively affect the pancreatic Langerhans cells activity and architecture.
Novel Virulence Factors Deciphering Klebsiella pneumoniae KpC4 Infect Maize as a Crossing-Kingdom Pathogen: An Emerging Environmental Threat
Authors: Huang Min , He Pengfei , He Pengbo , Wu Yixin , Munir Shahzad , He Yueqiu 
Published: December 2022

Klebsiella pneumoniae is not only a human and animal opportunistic pathogen, but a food-borne pathogen. Cross-kingdom infection has been focused on since K. pneumoniae was identified as the pathogen of maize, banana, and pomegranate. Although the pathogenicity of K. pneumoniae strains (from ditch water, maize, and human) on plant and mice has been confirmed, there are no reports to explain the molecular mechanisms of the pathogen. This study uncovered the K. pneumoniae KpC4 isolated from maize top rot for the determination of various virulence genes and resistance genes. At least thirteen plant disease-causing genes are found to be involved in the disruption of plant defense. Among them, rcsB is responsible for causing disease in both plants and animals. The novel sequence types provide solid evidence that the pathogen invades plant and has robust ecological adaptability. It is imperative to perform further studies on the verification of these KpC4 genes’ functions to understand the molecular mechanisms involved in plant–pathogen interactions.
Rickettsia Infection Benefits Its Whitefly Hosts by Manipulating Their Nutrition and Defense
Authors: Fan Ze-Yun , Liu Yuan , He Zi-Qi , Wen Qin , Chen Xin-Yi , Khan Muhammad Musa , Osman Mohamed , Mandour Nasser Said , Qiu Bao-Li 
Published: December 2022

Endosymbionts play an essential role in the biology, physiology and immunity of insects. Many insects, including the whitefly Bemisia tabaci, are infected with the facultative endosymbiont Rickettsia. However, the mutualism between Rickettsia and its whitefly host remains unclear. This study investigated the biological and physiological benefits of Rickettsia infection to B. tabaci. Results revealed that infection of Rickettsia increased the fertility, the survival rate from nymph to adult and the number of female whiteflies. In addition, this facilitation caused a significant reduction in nymphal developmental duration but did not affect percentage rate of egg hatching. Rickettsia infected B. tabaci had significantly higher glycogen, soluble sugar and trehalose contents than Rickettsia negative B. tabaci individuals. Rickettsia also improved the immunity of its whitefly hosts. Rickettsia infested B. tabaci had lower mortality rates and higher semi-lethal concentrations (LC50) when exposed to the fungus Akanthomyces attenuatus and the insecticides imidacloprid and spirotetramat. The percentage of parasitism by Encarsia formosa was also reduced by Rickettsia infection. Overall, Rickettsia infection benefits B. tabaci by improving the nutritional composition of its host, and also protects B. tabaci by enhancing its resistance towards insecticides (imidacloprid and spirotetramat), entomopathogenic fungi (A. attenuatus) and its main parasitoid (E. formosa); all of which could significantly impact on current management strategies.
Portrait d'un équipement en émergence continue
Authors: Creuze Cécile 
Published: December 2022

L'émergence est un terme, lui aussi neuf, émergent, qui tente d'apporter des éléments de définition dans le champ de la jeunesse, de ses pratiques et de leur prise en compte par l'État. Si ce terme dit bien que l'on ne peut plus faire sans ces pratiques, que l'on ne peut plus ignorer la jeunesse qui prend sa place malgré tout, il contient des limites certaines.
Travaillant sur un équipement de diffusion de musiques amplifiées et sur son implantation locale autant que sur son implication (forcée) dans les aléas des politiques publiques culturelles, l'auteur constate que l'émergence n'est pas une position de revendication, mais bel et bien un signe de précarité.
Du prosélyte et du pouvoir. Logiques d'exclusion et logiques d'intégration dans la pensée rabbinique
Authors: Attias Jean-Christophe 
Published: December 2022

Proselitismo y poder.
Lógicas de exclusión y lógicas de integración en el pensabiento rabinico.
La conversión al judaismo no es unicamente la adhesion a un credo, es tambien la entrada en de una historia, la participación en una memoria colectiva, la integración en una comunidad nacional. De manera mas precisa, la entrada del prosélito en Israel maltrata inevitablemente la vision genealógica de la identidad judia. Es como un centro candente, como un polo de resistencia que es dificil de sobrepasar. La dificultad se exprime abiertamente a partir del momento en que se trata de saber si el prosélito puede asumir, dentro de la comunidad que lo acoge, una función especifica que implique el reconocimiento de un privilegio o de una precedencia, incluso la atribución de un poder sobre otros miembros de la comunidad. ¿Un prosélito puede ser rey o Sumo Sacerdote? Aún mas, en tanto que colectividad depositaria de un mensaje revelado ¿Israël puede investir a un prosélito de una autoridad de proféta? ¿O de la de sabio? ¿Es que su minusvalia genealógica puede no tener ninguna repercusión con relación a la Revelación o su saber con respecto a los textos sagrados?
Les Sarrasins en vallée Française ? Genèse et perception contemporaine d'un récit légendaire en Cévennes
Authors: Laurence Pierre 
Published: December 2022

Saracens in French Valley ?
Genesis and Modern Perception of a Fegenday Tale in Cévennes. The Saracen legend in French valley (Cévennes) illustrates a very common type of story in Southern France, both in erudites spoken and written tradition. It combines battle relation, toponymie interpretation and legendary lineage. Its origin goes back to the 19th century in a time of religious rivalry, which is not without consequence on its modern perception.
Histoire de l'immigration en Belgique. Heurts et malheurs des projets pour un musée
Authors: Morelli Anne 
Published: December 2022

■ Morelli
Desencuentros y desdichas de los proyectos para un Museo de la inmigración en Bélgica
Desde hace quince años, y a pesar de diversas iniciativas, los intentos por crear en Bélgica un Museo de la Inmigración se han enfrentado a numerosos obstáculos tanto materiales como políticos. Los últimos proyectos parecen privilegiar el aspecto social y cultural de una «Casa de las Migraciones» y poner en entre dichos la dimensión que le corresponde a la historia y a la memoria, lo cual implicaria la reunión de colecciones documentales, su clasificación, almacenaje y su explotación, todos aspectos fundamentales para cualquier museo. En 2005, tanto el porvenir de este proyecto como su contenido siguen siendo muy inciertos...
Beetween Oblivion and Representation. Commemorating Contemporary Migration History in Germany
Authors: Ohliger Rainer , Motte Jan 
Published: December 2022

■ Ohliger & Motte
Entre oubli et représentation : commémorer l’histoire contemporaine des migrations en Allemagne.
Les discours concernant la mémoire et l'immigration sont tous deux très présents dans la société allemande contemporaine. Cependant, ils ne se croisent que rarement. Les débats sur la mémoire et la commémoration sont essentiellement centrés sur le passé national-socialiste de l'Allemagne, alors que la migration est plutôt vue comme un sujet social et politique d'actualité. L'article analyse et illustre les points de rencontre potentiels entre les deux thèmes. Il donne des exemples de discours publics et de représentations institutionnelles quant à l'histoire des migrations en Allemagne.
Mémoire en débat, mémoires en travail. L'histoire de l'immigration au prisme d'initiatives locales
Authors: Teulières Laure 
Published: December 2022

■ Teulières
Memorias en debates, memorias en trabajo : la historia de la inmigración a través del prisma de las iniciativas locales
Frente al envite, hasta ahora ampliamente afirmado, de otorgar todo su lugar a la inmigración dentro de la memoria colectiva, no cabe considerar únicamente a los movimientos de fondo que operan a nivel nacional. También es necesario tomar en cuenta las evoluciones que se esbozan en un marco regional, y hasta en el local. De allí la idea de interrogar, tomando en cuenta todas sus diversidades, distinctos tipos de iniciativas públicas que intentan, localmente, manifestar, conmemorar o poner en debate la historia de la inmigración.
Entre mémoire institutionnelle et mémoire personnelle. Quelle mémoire partagée de la migration portugaise en France ?
Authors: Dos Santos Irène 
Published: December 2022

■ Dos Santos
Entre mémoires institutionnelles et mémoires personnelles : quelle mémoire partagée de la migration portugaise en France ?
La confrontation de pratiques commémoratives de l'émigration, au Portugal, et des représentations de la migration parentale chez des jeunes franco-portugais, met en évidence l'occultation d'une histoire récente. L'auteur questionne dès lors la construction, en cours, au sein d'espaces associatifs franco-portugais, d'une mémoire partagée de la migration portugaise.
Reproduction ou création ? Images, pratiques et objets religieux arméniens dans l'exil à Los Angeles
Authors: Mekdjian Sarah 
Published: December 2022

¿Reproducción o creación ? Imágenes, prácticas y objetos religiosos armenios del exilio en Los Angeles
El genocidio de 1915 significó una dispersión a gran escala del pueblo armenio. La pérdida de imágenes y objetos religiosos a la vez material y espiritual. ¿En que medida estos elementos de lo religioso son reproducidos de una manera idéntica en el exilio en Los Angeles? ¿O hasta que punto son reinventados, conforme a procesos creativos?