bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective Analysis of Patients with Percutaneous Dilatational Tracheostomy in Intensive Care Unit
Authors: KOCAYİGİT Havva , ÖZMEN SÜNER Kezban , PEKŞEN Özge , KIZILIŞIK Halil , TOMAK Yakup 
Published: March 2022

INTRODUCTION: Tracheostomy is a method frequently applied in intensive care units with the indication of prolonged intubation. [1] Our aim in this study is to retrospectively analyze the percutaneous dilatational tracheostomy (PDT) cases performed in our clinic within 1 year.
METHODS: It's analyzed the patients who underwent PDT in Sakarya Training and Research Hospital, Anesthesia Intensive Care Unit between January 2019 and December 2019. Each patient's age, gender, diagnosis of intensive care admission, use of anticoagulant drugs, and APACHE II score were recorded. Then, the day of tracheostomy procedure, complications, total intensive care unit stay, and the patient's discharge from the intensive care unit were evaluated.
RESULTS: A total of 79 patients were found to have undergone PDT. It was observed that the mean age of the patients was 66.56±17.83 and 48 (60.8%) were male. It was observed that 25(31.6%) of the patients were admitted to the intensive care unit with the diagnosis of postresuscitation syndrome, 17 (21.5%) cerebrovascular accident, and 15(19%) pneumonia. The mean APACHE II scores of the patients were 24.1±6.2, and 16(20.3%) patients were discharged. The median PDT procedure day was 19.5[12-30]. It was determined that only 2 of the patients had minor and 1 major and 3 (3.9%) patients did not develop any other complications apart from the bleeding related complication.
DISCUSSION AND CONCLUSION: In our study, although 66 (83.6%) of the patients who underwent PDT procedure received anticoagulant-antiaggregant treatment, postoperative bleeding rates were observed to be quite low in accordance with the literature.
Results of adjustable intragastric balloon use according to Body Mass Index values
Authors: TURHAN Veysel Barış , ÖZTÜRK Doğan , ŞAHİN Mutlu , KESKİN Müge , BULUŞ Hakan 
Published: March 2022

Aim: In our study, it was aimed to compare the results of adjustable intragastric balloons in patients according to body mass index.
Material and Method: We recorded the data of 82 patients that we performed AIGB procedure in the last four years. During the initial implantation of the balloon, inflating was performed with 300-350 cc saline and methylene blue. Body mass index values and excess weight loss ratios of the patients at the time of the balloon removal were noted. Patients' complaints and complications arising after balloon application or additional inflation were reported.
Results: It was determined that there was a statistically significant decrease between weight, BMI, and EWL values measured at the 4th, 8th, and 12th months after the first application was performed (p
The impact of diabetes mellitus on levels of sex hormones and their receptors in tumor tissues in female rats with Guerin’s carcinoma
Authors: Frantsiyants E. M. , Bandovkina V. A. , Kaplieva I. V. , Surikova E. I. , Pogorelova Yu. A. , Cheryarina N. D. , Kotieva I. M. , Morozova M. I. , Shikhlyarova A. I. 
Published: March 2022

Purpose of the study. Analysis of the effect of DM on levels of sex hormones and their receptors in tumor and perifocal tissues in outbred white female rats.Materials and methods. Outbred white female rats were divided into 2 groups, 18 rats each: control group – with transplantable Guerin’s carcinoma, main group – with transplantable Guerin’s carcinoma growing in presence of DM. DM was reproduces in animals by the single intraperitoneal alloxan injection (150 mg/kg body weight). Animals were killed after 10 days of the tumor growth. Levels of hormones (estradiol, testosterone, progesterone and prolactin) and their receptors (RЕα, RЕβ, RA and RP4) were measured by ELISA in tumor and perifocal tissues in animals of the control and main groups.Results. Female rats with Guerin’s carcinoma growing in presence of DM showed an increase in glucose in tumor and perifocal tissues by 1.8 times (р < 0.05) and 7.6 times, respectively, compared to the levels in the control group. Levels of E2 were increased, respectively, by 2.4 and 9.5 times; P4 – by 2.1 and 3.0 times; PRL – by 2.7 and 4.4 times. T was increased in perifocal tissues by 2.2 times and was unchanged in tumor tissues. RЕα and RP4 were elevated by 3.9 and 3.0 times, respectively, only in tumor tissues, and RA by 3.9 times only in perifocal tissues. The REα/RЕβ ratio was increased only in the tumor by 3.2 times. The Е2/RЕβ ratio was increased in tumor and perifocal tissues by 2.0 and 9.6 times, respectively. The T/RA ratio was decreased in the tumor and its perifocal area by 1.4 (р < 0.05) and 2.0 times, respectively. The opposite changes were observed in the Е2/RЕα and P4/RP4 ratios: a decrease in the tumor by 1.6 and 1.4 times, respectively (р < 0.05), and an increase in the perifocal area by 9.8 and 2.5 times, respectively.Conclusion. Female rats with Guerin’s carcinoma growing in presence of DM demonstrated local hyperglycemia, changes in the levels of sex steroids and a misbalance in their receptors in tumor and perifocal tissues causing active metastasis and reduced average survival of animals.
Analysis of Gene Expression Omnibus high-throughput sequencing data for the determination of microribonucleic acids in the blood plasma of patients with glioblastomas
Authors: Pushkin A. A. , Gvaldin D. Yu. , Timoshkina N. N. , Rostorguev E. E. , Vladimirova L. Yu. , Dzenkova E. A. 
Published: March 2022

Purpose of the study. This work is devoted to the study of blood plasma miRNA patterns in blood plasma using high-throughput sequencing of the Omnibus Gene Expression base and the search for candidate miRNA molecules for the development of a minimally invasive diagnostic panel.Materials and methods. Basing on the open dataset of Omnibus Expression of the NCBI GSE150956 Gene, groups of samples with glioblastoma and conventionally healthy donors were formed. For each sample, information on the levels of miRNA expression was extracted. Determination of significant miRNAs using machine learning algorithms of the R 4.0.4 project. For significant miRNAs, target genes have been performed, an analysis of the improvement of functional characteristics and interactome analysis of target genes of miRNA were performed.Results. The study analyzed the data of 131 samples, where 35 samples with glioblastoma and 96 samples of the conditionally healthy group. Differential expression data were obtained for 945 miRNA. Two panels were obtained using machine learning methods, common miRNA – hsa-miR 3180, hsa-miR 3180-3p, hsa-miR 6782-5p, hsa-miR 182-5p, hsa-miR 133b and hsa-miR 670-3p. For significant miRNAs, information was obtained on experimentally confirmed target genes, a gene ontology demonstrating their participation in enzyme binding, participation in the regulation of primary cellular metabolic processes, and the development of glioblastomas and cancer in general.Conclusion. As a result of layer-by-layer filtering and application of machine learning algorithms, significant miRNAs were identified that are candidates for a diagnostic panel of a minimally invasive method of high-grade glial tumors.
An overview of heat-stress response regulation in Gram-negative bacteria considering Escherichia coli as a model organism
Authors: Paul Deborupa , Ghosh Sanmitra 
Published: March 2022

Response to heat stress (HSR) is a key stress response for endurance in Escherichia coli mediated by transcriptional factor σ-32. Even though there has been extensive investigation on the contribution of proteins and chaperones in retaining protein stability in cells under stress conditions, limited information is available regarding the dynamic nature of mechanisms regulating the activity of the highly conserved heat shock proteins (Hsps). Several gene expression-based studies suggest the pivotal role of Hsp70 (DnaK) in the regulation of the expression of heat shock genes (Hsg). Direct interaction of Hsp70 with σ-32 may regulate this function in E. coli. Recent studies revealed that localization of σ-32 to the membrane interior by SRP-dependent pathway enables them to function appropriately in their role as regulators. The contributions of different cellular components including cell membrane remain unknown. Other cellular components or σ-32 interfere with polypeptides which could play a crucial role in cell survival. Sigma factor monitors and preserves outer membrane integrity of E. coli by stimulating the genes regulating outer membrane proteins (OMPs) and lipopolysaccharide (LPS) assemblage as well as through expression of small RNAs to down-regulate surplus unassembled OMPs. σ-E activity is regulated by the rate at which its membrane-encompassing anti-sigma factor, RseA is degraded. Mutations in rseA are reported to constitutively increase the sigma (E) activity that is validated at both genetic and biochemical levels. In this review, the basic mechanism of heat stress regulation in gram-negative bacteria has been elaborated using E. coli as a model organism.
The distribution and the related factors of forward head posture among medical students
Authors: KÖSE Elif , BAYLAN Hüseyin , KARAHAN Hilal , EKERBİÇER Hasan 
Published: March 2022

Objective: Forward head posture (FHP) is becoming common in medical students who study for long durations with wrong postures due to intensive curriculum. This study was conducted to determine the frequency of FHP and related factors in medical students.
Method: The first and second-year medical students filled out the questionnaire including sociodemographic characteristics, activity status, Smartphone Addiction Questionnaire, Beck Depression, Body Awareness, and Perceived Stress Scales after their verbal consent was obtained. FHP and craniovertebral angle values were measured.
Results: 47% of the students had highly severe (≥5 cm), 46.2% had severe FHP (2.5-5 cm), and 6.8% had mild FHP. The mean CVA (Costovertebral Angle) values were determined as 44.31 ± 4.31. The frequency of students whose CVA values are below 45° is 59.3% (140 people). The frequency of highly severe FHP was also found as high in the taller, in males, and in the students with high BMI. In the regression model examining the situations that increase the risk of severe FHP, it was found that depression increased the risk of FHP 2.5 times.
Conclusion: FHP was found to be very common (90%) in medical students. FHP was found to be more severe in students with high depression scores.
Intense Cooling during Composite Rock Breaking of High-Pressure CO2 Jet-Polycrystalline Diamond Cutter
Authors: Cai Can , Yang Xian-Peng , Gao Chao , Pu Zhi-Cheng , Zhang Pei , Tan Zheng-Bo , Li Bangrun , Xie Song 
Published: March 2022

SummaryIn deep well drilling, rock breaking has some problems, such as low rock breaking efficiency, serious thermal wear of cutters, short service life, and high cost. It is noticed that the application of CO2 drilling fluid in the oil and gas underbalanced drilling is an efficient approach to achieve the reduction of CO2 emissions. Thus, based on the rock-breaking advantages of CO2 jetting, a new rock-breaking method of combing high-pressure CO2 jet and polycrystalline diamond cutter (PDC) is proposed in our study. The cooling mechanism and influencing during rock breaking by using the high-pressure CO2 jet-PDC are conducted. With the test system during composite rock breaking of the high-pressure CO2 jet-PDC, the composite rock-breaking experiment of the high-pressure CO2 jet-PDC was carried out. In the experiment, the comparison of the CO2 jet, N2 jet, water jet, and without a jet was conducted and analyzed. And based on the numerical simulation analysis, the intense cooling mechanism was expounded. In the process during composite rock breaking of the high-pressure CO2 jet-PDC, the intense cooling mechanism was mainly attributed to three main reasons: the thermal effect of the jet flow, the expansion endothermic effect of the jetted flow, and the phase transformation cooling effect of the CO2 jet. The effects of rock samples, jet temperatures, jet flow pressures, and rock temperatures on the cutting temperature were experimentally explored, and finally, the intense cooling rules of composite rock breaking were obtained. The experimental results showed that the CO2 jet had a stronger cooling effect on granite than that of the sandstone. In a certain range, jet pressure was positively correlated with the cutting temperature, whereas jet temperature and heating time were negatively correlated with cutting temperature. The study provides the theoretical support for the CO2 application as a drilling medium in underbalanced drilling.
Polymyositis as a Paraneoplastic Syndrome of a Patient With Primary Pulmonary Lymphoepithelioma-like Carcinoma: a Case Report and Literature Review
Authors: Lei Yu , Liu Caiyang , Wan Xiu , Yang Yanhui , Yao Yi , Luo Lei , Huang Tingyu , Li Ji 
Published: March 2022

Abstract
Background Pulmonary lymphoepithelima-like carcinoma (LELC) is a rare type of non-small cell lung cancer, which mostly occurred in non-smoking Asian populations. The prognosis of this tumor is better than other lung cancers. Polymyositis, a kind of idiopathic inflammatory myopathies, may negatively affected the prognosis of patients with lung cancer as a paraneoplastic syndrome (PNPS). LELC seldomly accompanied with paraneoplastic syndrome, thus the treatment strategy and prognosis should be discussed.Case presentationWe report a 49-year-old female patient who was hospitlaized for “ symmetric limb weakness and pain for more than 2 months”. Glucocorticoid-based anti-inflammatory therapy had been performed for over 3 weeks before the patient being hospitalized, however, in vain. The result of serum autoimmune antibody showed Anti-nRNP/Sm (+). The serum level of myoglobin, lactate dehydrogenase and creatine kinase elevated significantly. Electromyogram revealed peripheral nerves injury and myogenic damages. Imaging showed a mass in the posterior basal segment of the left lung. Percutaneous transthroacic needle biopsy was performed and the pathological result was LELC. The patient was diagnosed with pulmonary LELC accompanied with polymyositis. Positron emission tomography computed tomography showed only lpsilateral hilar and mediastinal lymph nodes metastasis. Video-assisted thoracoscopic surgery for the left lower lobe resection and systematic mediastinal lymphadenectomy were performed. Postoperative pathological stage was T2N2M0, IIIa(UICC 8th), and the patient received adjuvant chemotherapy and subsequent radiotherapy. The patient was followed up for 5 months with no recurrence of tumor and the limb weakness and pain relieved apparently after the successful comprehensive treatment of her primary tumor.Conclusion PM is associated with lung cancer, ignoring this relationship may lead to missed diagnosis in clinic. Pulmonary LELC is a rare subtype of NSCLC seldomly accompanied with PNPS. Though PNPS negatively affected the prognosis of patients with other lung cancers,surgery based comprehensive treatment of primary tumor can lead to a prospective prognosis in pulmonary LELC patients with PNPS. And successful treatment of pulmonary LELC can also improve symptoms of PNPS.
Assessment of Patients Health-Related Quality of Life During Complications of Pregnancy in a Tertiary Care Teaching Hospital: a Prospective Study
Authors: Jain Vartika , Singh Avinash kumar 
Published: March 2022

Abstract
Background and Objective: Pregnancy has undesirable effects on women lives which lead to reduction in quality of life. Assessment of Quality of Life is necessary among pregnant women because of association with the various complications. Hence, the present study was conducted to evaluate the patient’s health-related quality of life during complications of pregnancy.
Method: A prospective observational single centered study was conducted on 81 pregnant women who were diagnosed with complications (Anemia, UTI, Pre-eclampsia and Hyperemesis gravid arum) in Obstetrics & Gynecology department of NIMS Hospital, Jaipur, (Rajasthan).
Result: The mean score of physical component scale (PCS) and mental component scale (MCS) was found to be 58.43±0.70 and 75.8±1.25 respectively. The mean score at the time of discharge were physical functioning 69.8±13.77, role limitation due to physical problems 79.01±16.15, role limitation due to emotional problems 68.00±17.10, vitality 48.68±7.30, mental health 98.64±4.25, social functioning 87.22±18.71, bodily pain 80.61±12.67, general health 72.5±4.06 and reported health transition 82.71±12.89 and overall score at p-value was found to be significant.
Conclusion: HRQoL of pregnant women associated with complications has been improved where mental health tends to recover more quickly than physical health.
Keywords: Quality of Life; Anemia; UTI; Pre-eclampsia; Hyperemesis gravidarum.
Impact of six weeks trimodal prehabilitation program on short-term functional recovery for elderly patients undergoing colorectal cancer surgery
Authors: Liu Bin , Zheng Lei , Li Yousheng 
Published: March 2022

Abstract
Background and objectives
The impact of prehabilitation on physical fitness and postoperative course after colorectal cancer surgery for elderly patients is unknown. The aim of this study was to assess whether a 6-week trimodal prehabilitation program (exercise, nutritional supplementation, and counseling on relaxation techniques) is sufficient to modify physical fitness, nutritional status, and postoperative outcomes of patients undergoing colorectal cancer surgery for elderly patients.
Materials and methods
From January 2018 to October 2021, the clinical data of patients undergoing cancer surgery in our department were collected. Patients were assigned to either a prehabilitation (n=26) or matched time control group (n=26). Patients before the introduction of prehabilitation were included as historical control subjects for 1:1 propensity score-matching (control group). Over the 6-week period prior to surgery, patients in prehabilitation group participated in a trimodal prehabilitation program. Patients in control group received the same program but only postoperatively. The 6-min walk test (6MWT) was used for assessment of functional walking capacity. Hospital anxiety and depression scale (HADS) score was recorded before intervention and before operation. The recovery of intestinal function, postoperative complications, the length of hospital stay were compared between the two groups.
Results
Over the preoperative period, serum albumin levels were significantly deteriorated in the control group, whereas this index did not deteriorate or even improved in the prehabilitation group. By performing prehabilitation, prehabilitation group significantly increased the amount of moderate and vigorous intensity physical activities that they performed. Prehabilitation group patients also demonstrated a greater improvement in 6MWT compared to Control group during the prehabilitation period. Although the overall incidence of postoperative complications did not differ between the two groups, the postoperative hospital stay and recovery of intestinal function was shorter in the prehabilitation group than in the control group.
Conclusions
These findings highlight that the positive effects of a trimodal prehabilitation program can significantly improve the perioperative physical function, psychological status and nutritional status of patients on elderly colorectal cancer patients within the 6-week prehabilitation period are an achievable goal and could have a significant effect on the cancer care continuum.
Future Land Use/Land Cover Scenarios Considering Natural Hazards Using Dyna-CLUE in Uzungöl Nature Conservation Area (Trabzon-NE Turkey)
Authors: Aydın ABDURRAHİM , Eker Remzi 
Published: March 2022

Abstract
This study aimed to determine past and potential future temporal and spatial changes in land use/land cover (LULC) and to evaluate its interactions with natural hazards (especially snow avalanches and rockfalls) in Uzungöl Nature Conservation Area (UNCA) (Trabzon- NE Turkey). The objectives were; 1) to assess past LULC change for last 60 years (1955–2015), 2) to simulate future LULC with Dyna-CLUE by 2050 considering two different scenarios, and 3) to evaluate interactions of past and future LULC change with natural hazards. The analysis of past LULC change showed an increase of 51.03 ha in settlement for last 60 years resulted from conversion fully from agriculture. From future LULC simulations, Scenario 1 resulted that settlement will grow towards areas exposed to snow avalanches, from 68 ha in 2015 up to 97.5 ha in 2035, and 126.5 ha in 2050. Scenario 2 resulted that these settlement areas will grow up to 119.75 ha in 2035 and 137.75 ha in 2050. In addition, Scenario 1 resulted that settlement exposed to rockfall hazard will change from 28 ha in 2015 to 24 ha in 2035 and 28.25 ha in 2050, whereas Scenario 2 resulted that these areas will change to 26.25 ha in 2035, 28.75 ha in 2050. This study showed how LULC dramatically changed since 1955 due to population growth and changes in consumption patterns in society, and how could be changed potentially in the future. It was concluded that an obligatory increase in settlement towards dangerous areas will be observed in future.
A Novel Ultra-Miniaturized THz Refractive Index-Based Material Sensor
Authors: Mathivanan Anbuselvi , Veeraselvam Aruna , Mohammed Gulam Nabi Alsath 
Published: March 2022

Abstract
This paper discusses the design, characterization and analysis of an ultra-miniaturized and highly sensitive metamaterial THz sensor for material sense. A novel spin-shaped resonator integrated with hexagonal is designed as an absorber to perform material sensing operations. The footprint of the proposed sensor is 0.67λeff × 0.67λeff where λeff is the effective wavelength calculated at 7.16 THz. The proposed THz sensor is analyzed based on the absorption characteristics by estimating the sensitivity of the metamaterial sensor. The proposed sensor offers 99.9% absorptivity under free-space conditions. The proposed THz sensor exhibits rotational symmetry and hence it is insensitive to polarization changes. Furthermore, the proposed sensor is angularly stable for oblique incidences up to 60˚. The sensor performance is estimated for different refractive indices of various analytes and the average sensitivity is estimated as 1.37 THz/Refractive Index Unit (RIU). The impact of the thickness of the analyte is analyzed and the average deviation of 59 GHz/µm is reported. Thus, it is concluded that the proposed metamaterial THz sensor is best suitable for different material sensing applications.