bluuebunny/crossref_metadata_2025_split huggingface dataset:
FRIENDSHIP QUALITY IN COLLEGE PREDICTS WELL-BEING IN QUALITATIVE LIFE REFLECTIONS 50 YEARS LATER
Authors: Chopik William 
Published: January 2025

Abstract
Theories of successful aging and psychosocial development posit that well-being later life indicates successful adaptation and portends a longer life. In identifying antecedents to late life well-being, close relationships have emerged as a prominent antecedent for health and well-being across life. However, prospective studies examining the impact of social relationships on health and well-being are relatively rare, particularly mixed methods studies. I paired the Harvard Student Study Class of 1964 (N = 252) with qualitative reflection data in their alumni class reports every five years after graduation for over fifty years. Machine learning techniques will be featured depicting how psychological traits can be inferred through autobiographical reflections. Having more friends and closer friends during their freshman year of college (at age 22) was associated with more positive life reflections (r =.22), more positive relationships (r =.23), and less mental illness (r = -.25) fifty years later (at age 72). I will then leverage these archival sources to examine the impact of social relationships on health and well-being across nearly 100 years to test secular changes in a newly constructed cohort sequential design. Emerging methods for linking family reports across generations and cohorts will be discussed and preliminary results presented. The discussion of the talk will focus on the antecedents of successful aging and how to leverage existing data—in its many forms—to study psychosocial development within a person’s life and across historical time.
AGE DIFFERENCES IN THE FREQUENCY AND NATURE OF ADULTS’ DAILY INTERACTIONS WITH OTHERS
Authors: Fiori Katherine , Rauer Amy , Birditt Kira , Turkelson Angela , Huxhold Oliver 
Published: January 2025

Abstract
Decades of research show that although adults’ social networks tend to shrink with age, the proportion of closest ties stays relatively constant and older adults rate their relationships as more positive. However, little research has examined with whom adults actually interact on a daily basis and the nature of those interactions. We used hierarchical network mapping data and ecological momentary assessment to examine whether there were age differences in social interaction types (inner circle, middle/outer circles, outside network) and in their valence (positive, negative, ambivalent), and if age moderated the link between interaction type and valence. Participants from the Stress and Well-being in Everyday Life (SWEL) study (N = 168; M age = 52.96, range = 33-91; 66.1% female; 47.6% Black) completed surveys every three hours for 4-5 days, reporting a total of 5,771 social interactions. Results showed that 36.6% of all interactions occurred with people outside of the network. Furthermore, against common theoretical expectations, only interactions within the inner circle declined with age. Moreover, although older participants reported more positive and more ambivalent interactions overall than younger adults, age did not moderate the association between interaction type and valence. This indicates that the increased positivity in older adults’ interactions was not specific to inner circle ties, but rather cut across interactions with all types of ties. Examining interactions on a daily level provides new insights into the specificity of potential age effects in social relationships.
DEVELOPMENT, CONTENT VALIDATION, AND USER TESTING OF AN ICU FAMILY WORKBOOK FOR TRANSITIONS FROM HOSPITAL TO HOME
Authors: Scheunemann Leslie , Arivudainambi Aishwarrya , Isenberg Avital , Makeen Mutasim , Christensen Janelle , Donovan Heidi 
Published: January 2025

Abstract

Background
No evidence-based interventions provide education and training for families experiencing critical illness to adapt to the caregiving role and attend to self-care while caregiving across transitions from hospital to home.

Methods
We integrated literature with input from community engagement studios to develop a family-facing ICU Family Workbook addressing common unmet needs. A convenience sample of post-ICU family caregivers, clinicians, and researchers qualitatively and quantitatively assessed content validity related to 11 evidence-based elements. Given a strong content validity index, it is undergoing user testing with a convenience sample of 10 families experiencing critical illness to refine its structure and format.

Results
The ICU Family Workbook includes roughly 70 pages of content covering 11 elements: (1) identifying a transitional “system navigator”; (2) education on symptom management; (3) education on functional support; (4) caregiver needs assessment; (5) development of written plans; (6) financial, legal, employment and insurance resources; (7) interdisciplinary decision support; (8) online resources; (9) self-care/psychological support and referral; (10) education on communicating with clinicians; (11) respite resources. Overall content validity index was 0.93. Qualitative feedback informed revisions refining educational content, enhancing screening tools, and making clearer education and self-care recommendations. Early user testing suggests usability and acceptability to families and is informing additional refinement of its content and formatting. Conclusions: This publicly available ICU Family Workbook (www.picturethis.pitt.edu) has content validity for addressing 11 common gaps in caregiver support. After additional refinement based on user testing, it should undergo efficacy testing for improving caregiving and self-care for families after critical illness.
THE PHYSIOLOGIC COMPLEXITY OF PREFRONTAL OXYGENATION DYNAMICS IS ASSOCIATED WITH AGE AND COGNITIVE FUNCTION
Authors: Zhou Junhong , Hong Yinglu , Yu Wanting , Iloputaife Ike , Bao Dapeng , Manor Brad , Lipsitz Lewis , Jor’dan Azizah 
Published: January 2025

Abstract
The hemodynamics of prefrontal cortex (PFC) oxygenation are regulated by numerous elements over multiple temporal scales. The dynamics in the fluctuations of PFC oxygenation are thus complex. Age may alter the multiscale regulation of PFC oxygenation, leading to diminished physiologic complexity of this important regulatory process. We aimed to characterize the effects of age and cognitive demand on such complexity in younger and older adults and its relationship to cognitive performance. Twenty-four younger (aged 28±3 years) and 27 older adults (aged 78±6 years) completed this study. The oxygenation (HbO2) and deoxygenation (HHb) signals of the PFC were recorded using functional near-infrared-spectroscopy (fNIRS) during the n-back task of blank, identification-of-X (IdX), and 2-back conditions. We used multiscale entropy to quantify the HbO2 and HHb complexity of fNIRS. It was observed that older adults exhibited lower fNIRS complexity regardless of task condition (p=0.0005) and lower percent increase of complexity from blank (p=0.02) or IdX (p=0.01) to 2-back compared to younger. Both groups exhibited greater complexity during IdX and 2-back compared to blank condition (p&lt; 0.02). Those with greater HbO2 complexity had greater 2-back accuracy (p=0.02~0.04). Older adults with greater fNIRS complexity had faster reaction times (β=-0.56~-0.6, p=0.009~0.02); while younger with lower complexity had faster reaction times (β=0.58~0.62, p=0.01~0.02). Participants with greater increase of fNIRS complexity from blank to 2-back had faster 2-back reaction time (β=-0.68~-0.49, p=0.001~0.03). The complexity of fNIRS-measured PFC oxygenation fluctuations may capture the influence of aging and task demands on the regulation of prefrontal hemodynamics involved in cognitive task execution.
PERSONALITY AND ALLOSTATIC LOAD: TESTING HEALTHY NEUROTICISM IN HISPANIC AMERICANS OVER 50
Authors: Sevi Barış , Supiyev Adil , Gutierrez Angela , Terrera Graciela Muniz 
Published: January 2025

Abstract
Allostatic load (AL) measures the cumulative wear and tear resulting from chronic stress and life events. Hispanic populations report a higher risk for elevated AL. To diminish health inequities in socially disadvantaged populations, understanding the antecedents of AL is essential. Using data from the Health and Retirement Study, this study examines the Big-5 personality traits as predictors of AL among middle-aged and older Hispanic adults (age ≥ 50; n: 319). First, a conditional growth model was tested where baseline Big Five personality traits were entered simultaneously to test the association with AL over three time points in eight years (Time 1 = 2006/2008; Time 2 = 2010/2012; Time 3 = 2014/2016). Our findings indicate that higher conscientiousness at baseline was associated with lower AL, but the Big-5 personality traits did not significantly predict the rate of change in AL over time. As the healthy neuroticism hypothesis suggests that higher neuroticism, which is by itself associated with worse health, when combined with higher conscientiousness, may positively influence health outcomes, a second conditional growth model was tested with the interaction of neuroticism and conscientiousness added to the first model. Contrary to expectations, higher levels of neuroticism and conscientiousness were associated with higher baseline AL, with no significant association with the rate of change in AL. These results underscore the importance of personality in predicting AL but provide evidence that challenges the assumptions of the healthy neuroticism hypothesis.
ADAPTATIONS IN A DRUMMING AND HORTICULTURE INTERVENTION FOR OLDER PEOPLE LIVING WITH INTELLECTUAL DISABILITIES
Authors: Ihara Emily , Hand Michelle 
Published: January 2025

Abstract
People aging with intellectual and development disabilities (IDD) often experience intersectional discrimination, impacting multiple dimensions of wellness. Rhythm & Nature is a trauma-informed drumming and horticulture intervention that provides an inclusive and modifiable environment. Both activities involve bilateral stimulation, using alternating hand movements to help create connections between the left and right hemispheres of the brain, which can help improve anxiety symptoms, memory, creativity, and attention. The 8-week intervention was delivered two times, roughly one year apart. The convenience sample was drawn from attendees of an adult day center for older people living with IDD, who could participate in drumming, horticulture, or both activities. This presentation will provide qualitative analysis results of the eight participants in Group 1 and preliminary analysis of the 18 participants in Group 2. Themes from the Group 1 analysis included autonomy, voice, and creativity; fun, laughter, and joy; safe space for sharing; and skill development, affirmations, and confidence. The acuity level of Group 2 participants was higher and the group was larger, requiring different modifications by the two facilitators. Adaptations that improved accessibility included formatting the emojis differently on the pre/post forms, printing pre/post surveys on different colored paper to make it easier for them to follow, and focusing on one theme per session. Week 4 of Group 2 occurred during the center director’s last day. Participants were able to drum a farewell song and create a bouquet to convey meaningful goodbye messages. Further program examples and implications for research and practice will be provided.
CHRONOLOGICAL AGE MODIFIES THE RELATIONSHIP BETWEEN HEALTH COMORBIDITIES AND PERCEIVED HEALTH STATUS
Authors: Downer Brian , Castro Jose Cabrero , Brandt Anita 
Published: January 2025

Abstract
Societal norms perpetuate the notion that declining health is a normal part of aging. However, it is unclear whether chronological age modifies the relationship between health status and how middle-aged and older adults perceive their health relative to others their age. This analysis used data from 13,246 participants from the 2021 wave of the Mexican Health and Aging Study. Participants were asked if their health was better, the same, or worse than people their age. We grouped participants into four age groups (50-59, 60-69, 70-79, &gt;80) and the number of health conditions (0, 1, 2, 3, &gt;4). We used logistic regression models to estimate predicted probabilities of having better perceived health, adjusting for demographic characteristics, life satisfaction, depressive symptoms, and having been diagnosed with COVID-19. Nearly half (44.5%) of participants said their health was better than people their age, 46.1% said their health was the same, and 9.3% said their health was worse. The probability of better perceived health decreased with more health conditions and increased with age. The interaction between age and health conditions was statistically significant (p=0.009). The probability of having better perceived health decreased with more health conditions for participants aged 50-59, 60-69, and 70-79. Among participants aged &gt;80, the probability for better perceived health was similar for participants with 0, 1, 2, and 3 health conditions but was lower for participants with &gt;4 health conditions. Our findings suggest that older adults in Mexico have positive perceptions of their health despite a high prevalence of comorbid conditions.
EFFECTS OF CIRCADIAN MISALIGNMENT ON BEHAVIOR IN MAPT HUMANIZED MOUSE MODEL
Authors: Udenta Mesomachi , Gonzalez Andrea , Lin Qing , Dieterk Kristi , Koronowski Kevin , Palavicini Juan 
Published: January 2025

Abstract
The circadian rhythm is a natural biological process that regulates a multitude of processes including sleep-wake cycles, eating cycles and activity cycles. Circadian misalignment has been found to be related to many neurodegenerative diseases, one of them being Alzheimer’s Disease. Tauopathies, are a distinctive feature of Alzheimer’s Disease and other dementia related disorders. Tau is a protein that helps stabilize he internal structure of brain cells by supporting the microtubules needed for cell structure that oversee maintaining the integrity of the cell. Neurofibrillary tangles are formed when tau accumulates inside the neurons through a process called hyperphosphorylation. These tangles block the neurons transport system and effects the synaptic communication between the neurons which leads to cell damage and eventually cell death. This is the pathway that causes a lot of the major symptoms in Alzheimer’s Disease. In this project. we a MAPT mouse model was used conjunction with a chronic jet lag simulation. The MAPT Gene Replacement Mouse Model consists of genetically modifying mice to express human tau. The model replaces the mouse tau gene with the human tau gene. It can mimic the tau pathology that is seen in humans and allows mice to develop the tau related abnormalities that is seen in dementia related disorders. Studying how this is affected by circadian misalignment can help reveal how sleep wake cycles can influence tau pathology.
LACK OF SLEEP AND PERCEIVED SOCIAL ISOLATION
Authors: Vass Emma , Fiske Amy 
Published: January 2025

Abstract
As F. Scott Fitzgerald wrote, “The worst thing in the world is to try to sleep and not to.” Insomnia is related to multiple distressing health outcomes. Research suggests that one of these outcomes may be higher levels of loneliness (Hom et al. 2017). The aim of this study was to use secondary data analysis to examine the relationship between sleep duration and perceived social isolation among older and younger adults. This study hypothesized that shorter sleep duration would lead to greater perceived social isolation. A sample of 147,694 participants ages 18-64 and 87,343 participants ages 65-99, from the 2022 Behavioral Risk Factor Surveillance Survey (BRFSS) was used to conduct a linear regression analysis on the relationship between these two variables after controlling for gender and education level. The overall model was significant for both older and younger adults: older, R² =.027, F(3, 87339) = 433.41, p &lt;.001; younger, R² =.015 F(3,147690) = 1343.32, p &lt;.001. Regression coefficients were significant for both older, β=.099, p&lt;.001, and younger, β=.142, p&lt;.001, adults. Study results indicated that lower sleep duration is related to higher perceived social isolation in both older and younger adults. Nonetheless, effect sizes were small. With this information in addition to the aforementioned previous work, we can continue to explore the connection between loneliness and sleep problems.
DATA-DRIVEN APPROACHES TO UNDERSTAND PROTEOMICS SIGNATURES IN DEMENTIA: RESULTS FROM ELSA AND UK BIOBANK
Authors: Gong Jessica , Williams Dylan , Steptoe Andrew 
Published: January 2025

Abstract
Novel blood-based protein markers are crucial for understanding dementia’s biological mechanisms. Undertaking a data-driven, proteome-wide approach to understand the protein signatures in dementia, this study used the English Longitudinal Study of Ageing (ELSA) as the discovery cohort, and subsequently the UK Biobank (UKB) as the validation cohort, to estimate the associations between proteins and the risk of incident all-cause dementia (ACD), and dementia subtypes. Bidirectional Mendelian randomization (MR) and drug target MR were employed to establish causal evidence between proteins and dementia as well as cerebral white matter volume (WMV). Of the 276 proteins in 3249 samples from ELSA (229 incident ACD, 89 Alzheimer’s disease (AD), 41 vascular dementia (VAD)), over a median 9.8-year follow-up, two proteins (NEFL, RPS6KB1) were significant after full adjustments, using Cox Proportional Hazard regression models, with False Discovery Rate p-value set at 0.05 to indicate statistical significance. One protein (MMP12) was found to be associated with VAD. NEFL and RPS6KB1 in combination with demographic predictors (sex, age, education, race), along with APOE 4 genotype and memory score showed good predictive value (Area Under Curve (AUC)=0.87). All associations were replicated in UKB in 52,745 participants (1506 ACD, 732 AD, 281 VAD) over median 13.7-year follow-up. Causal evidence for MR indicated a backward association between dementia and NEFL; drug target MR indicated causal relationships between NEFL and AD and WMV, as well as MMP12 and VAD. This study highlights promising blood-based protein candidates for dementia diagnostics and therapeutic targets, emphasizing the potential for improving patient care.
FEASIBILITY OF VIRTUAL COMPANIONSHIP AND ACTIVITIES FOR PERSONS WITH DEMENTIA: MEMORI CORPS TRIAL
Authors: Marx Katherine , Herpst Jessica , Kirchner Kathleen , Samus Quincy 
Published: January 2025

Abstract
The majority of persons living with dementia (PLWD) are cared for at home by a family care partner. Social isolation, the need for meaningful activities, and care partner respite are common unmet care needs for PLWD. Home and community-based services such as Adult Day Care and friendly visitor programs have been instrumental in addressing these needs. However, not all families prefer out-of-home services, some lack service access, and few of these services are tailored specifically for PLWD. Additionally, the COVID-19 pandemic disrupted most services. This study evaluates the feasibility of providing virtual companionship and meaningful activities via Zoom to community-residing PLWD. Sixty-two dyads (PLWD and family care partner) and 52 trained volunteers (ages 55+), participated in a 12-week intervention. Individualized activity plans were developed based on the PLWD’s personal history, roles, interests, and current functional level. Activity sessions were offered up to five times a week for up to one–hour per session, primarily through Zoom. Advantages of virtual delivery included the ability to serve dyads across a large geographic area, resource efficiency, session flexibility allowing individual and group sessions, and the capability to continue services during participant travel. Drawbacks included low initial technology literacy levels of participants (e.g., session scheduling, joining, screen sharing), technical issues (e.g., hardware, Wi-Fi connection issues), need for in-home help for session setup on computer, limited selection of potential activities, and limited ability to evaluate and address environmental barriers impacting sessions. Overall, virtual implementation was feasible and allowed PLWD access to meaningful activity and socialization.
MACHINE LEARNING APPLIED TO MEDICARE CLAIMS DATA TO IDENTIFY OLDER ADULTS WITH UNDIAGNOSED DEMENTIA
Authors: Barnes Deborah , Benjamin Cynthia , Mannen Delia , Boscardin John 
Published: January 2025

Abstract
Approximately half of people living with Alzheimer’s disease and related dementias are undiagnosed. We performed a retrospective cohort study using the 5% Medicare claims sample to test machine learning approaches for calculating risk of undiagnosed dementia. For each calendar year from 2012 to 2021, we created a cohort of beneficiaries aged 65 years or older on January 1 who had at least 2 healthcare claims during the previous 2 years. Those who had prevalent dementia, were in hospice, or died within the calendar year were excluded. We identified those who received an incident dementia diagnosis during the calendar year (i.e., had undiagnosed dementia on January 1) and used machine learning methods to identify key predictors of undiagnosed dementia within each cohort based on demographics, diagnoses, and healthcare utilization. Model accuracy was assessed using c statistics. On average, 837,440 Medicare beneficiaries were included in each cohort, of whom 24,410 (2.9%) were diagnosed with incident dementia each year. An average of 35±10 variables were included using different machine learning approaches and cohort years. Overall model accuracy for detecting undiagnosed dementia ranged from 0.77 to 0.81. All models yielded clinically meaningful discrimination ranging from &lt; 1% (lowest predicted decile) to 13% (highest predicted decile). Model performance was stable temporally and across gender, race, and ethnicity. These results support application of machine learning with Medicare claims to identify older adults at risk of undiagnosed dementia. Future studies should prospectively validate this approach within healthcare systems and explore the potential value of additional data sources.
ASSOCIATION STUDY OF DNA METHYLATION AGE AND BONE HEALTH PHENOTYPES IN OLDER TWINS
Authors: Soerensen Mette , Christensen Kaare , Kassem Moustapha 
Published: January 2025

Abstract
DNA methylation age, a biomarker for biological aging, is reported to associate to mortality and several aging-related phenotypes, while studies of bone phenotypes are surprisingly rare. Here we explore the association between diagnoses on age-related bone fractures, osteoporotic bone fractures, and osteoporosis without factures from the Danish Patient Registry to seven DNA methylation clocks: Horvath, IEAA, Hannum, EEAA PhenoAge, GrimAge and DunedinPACE. Cox regression analysis in a discovery sample of 310 older twins (age 73-91) revealed all clocks to reflect an increased epigenetic age with increasing risk of diagnosis; especially GrimAge and DunedinPACE appeared consistent across all three disease groups. A replication cohort of 777 twins (age 30-79) reflected the same direction of effect, with DunedinPACE displaying statistical significance. A twin pair analysis, reducing genetic and environmental confounding, confirmed the direction of effects, with GrimAge holding the largest effect sizes (e.g., HR=1.21, P=0.057 for osteoporotic fractures). In all analysis the DNA methylation-estimated telomere length reflected the opposite direction of effect, i.e., shorter telomere length with increased risk of diagnosis. Lastly, for a subset of the replication cohort (N=288, age 30-76) data on bone mineral density (BMD) and the bone turn over markers CTX and P1NP were available; CTX and P1NP showed decreased levels with increasing epigenetic age, while BMD showed an inconsistent pattern. Interaction analysis revealed age and sex effects for some of the clocks for BMD, perhaps pointing to the complex mechanisms behind bone biology. Taken together we report associations between DNA methylation age and bone health phenotypes.