bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of IT identity on consumer negatively-valenced engagement in mobile medical consultation: from consumer experience perspective
Authors: Zhang Wenjing , Li Dong 
Published: August 2022

PurposeThe mobile medical consultation (MMC) service is growing rapidly, but not all consumers are always willing to actively engage with it. To address this issue, based on IT identity theory, this study explores the underlying mechanism of how two types of platform-related consumer experience influence MMC platform identity, in turn, result in consumer negatively-valenced engagement in MMC.Design/methodology/approachThe data was collected from 400 consumers with the experience of MMC and analyzed by the partial least square (PLS) method.FindingsThe findings unfold that these two distinct consumer experience, servicescape experience (i.e. perceived telepresence and perceived platform surveillance) and service search experience (i.e. perceived diagnosticity and perceived serendipity), are associated with MMC platform identity and consumer negatively valenced engagement with MMC.Originality/valueResearch on consumer negatively-valenced engagement in the field of MMC is still in a nascent stage. The study identifies consumer experience in accordance with the unique context of the MMC platform and fills the research gap on the role of IT identity in consumer negatively valenced engagement.
The influence of market power on liquidity creation of commercial banks in Vietnam
Authors: Nguyen Tran Thai Ha , Phan Gia Quyen , Wong Wing-Keung , Moslehpour Massoud 
Published: August 2022

PurposeThis research examines the relationship between market power and liquidity creation in the specific context of bank profitability in the Vietnamese banking sector.Design/methodology/approachThe study applies the methodology proposed by Berger and Bouwman (2009) to demonstrate the creation of bank liquidity through a three-step procedure for investigating the relationship between market power and liquidity creation. The three steps include non-fat liquidity (NFLC), fat liquidity (FLC) and system generalized method of moments estimation for panel data.FindingsThis study finds that liquidity creation increases when a bank has high market power. Further, highly profitable banks positively impact the market power of banks with regard to liquidity creation, relative to less profitable banks. Moreover, bank size, capital, economic growth and interest rate negatively influence bank liquidity creation, while credit risk positively relates to bank liquidity creation.Research limitations/implicationsMeasurements used in this study are based on the works of Berger and Bouwman (2009). There are specific variations, relative to Basel III. In addition, other variables significantly impact bank liquidity creation that have not been considered in the models, and a quadratic model should have been considered to measure market power and bank liquidity creation.Practical implicationsThis study suggests that managers should control the liquidity of their banks by supervising vulnerable characteristics that have been mentioned herein and emphasizing improvements in profitability. Further, the government may consider encouraging banks to generate more liquidity by modifying regulations concerned with market power or reinforcing policies about improving the transparent business environment.Originality/valueThis study characterizes an attempt to examine the influence of market power on the liquidity creation of banks in Vietnam, which represents one of the most dynamic systems in Asia, with several varied participating banks. The current study also examines the same within the specific context of the modifying impact of the profitability of banks.
Common and differential neural mechanisms underlying mood disorders
Authors: Rai Sabina , Griffiths Kristi R. , Breukelaar Isabella A. , Barreiros Ana R. , Boyce Philip , Hazell Philip , Foster Sheryl L. , Malhi Gin S. , Harris Anthony W. F. , Korgaonkar Mayuresh S. 
Published: August 2022

AbstractBackgroundDespite homogenous clinical presentations between bipolar and unipolar disorders, there are distinct neurobiological differences. Chronicity of illness may be a factor impacting and sustaining certain neural features. The goal of this study was to investigate common and shared neural mechanisms underlying mood disorders, and possible sustained neural changes relating to illness chronicity by investigating a cohort of euthymic patients with bipolar disorder (BD), unipolar depression who had responded to treatment (treatment‐sensitive depression, TSD), and a chronically treatment‐resistant depressed (TRD) group.MethodsOne hundred and seventy‐two participants (40 BD, 39 TSD, 40 TRD, and 53 age–gender‐matched healthy controls) underwent resting‐state fMRI scans. Seed‐based and independent component analyses were performed to investigate group differences in resting‐state connectivity between the four groups.ResultsAll three clinical groups had significantly lower connectivity within the frontoparietal network (FPN) relative to controls. TRD and BD were significantly different from TSD (TRD, BD > TSD) but were not significantly different from each other. TRDs were also significantly different from both BD and TSD for salience network connectivity with the posterior cingulate (DMN) and the FPN with frontal pole (DMN). Additionally, the BD group exhibited greater DMN‐FPN (sgACC‐RDLPFC) connectivity relative to TRD, TSD, and controls, which was correlated with a previous number of depressive episodes, in the BD group only.ConclusionsBD demonstrated shared and differential connectivity features relative to symptomatic TRD and euthymic TSD groups. The increased sgACC‐RDLPFC connectivity in BD and its correlation with a number of depressive episodes could be a neural feature associated with illness chronicity.
Delivering Spatially Comparable Inference on the Risks of Multiple Severities of Respiratory Disease from Spatially Misaligned Disease Count Data
Authors: Lee Duncan , Anderson Craig 
Published: August 2022

Abstract
Population-level disease risk varies between communities, and public health professionals are interested in mapping this spatial variation to monitor the locations of high-risk areas and the magnitudes of health inequalities. Almost all of these risk maps relate to a single severity of disease outcome, such as hospitalization, which thus ignores any cases of disease of a different severity, such as a mild case treated in a primary care setting. These spatially-varying risk maps are estimated from spatially aggregated disease count data, but the set of areal units to which these disease counts relate often varies by severity. Thus, the statistical challenge is to provide spatially comparable inference from multiple sets of spatially misaligned disease count data, and an additional complexity is that the spatial extents of the areal units for some severities are partially unknown. This paper thus proposes a novel spatial realignment approach for multivariate misaligned count data, and applies it to the first study delivering spatially comparable inference for multiple severities of the same disease. Inference is via a novel spatially smoothed data augmented MCMC algorithm, and the methods are motivated by a new study of respiratory disease risk in Scotland in 2017.
The immune response as a double‐edged sword: The lesson learnt during the COVID‐19 pandemic
Authors: Agrati Chiara , Carsetti Rita , Bordoni Veronica , Sacchi Alessandra , Quintarelli Concetta , Locatelli Franco , Ippolito Giuseppe , Capobianchi Maria R. 
Published: August 2022

AbstractThe COVID‐19 pandemic has represented an unprecedented challenge for the humanity, and scientists around the world provided a huge effort to elucidate critical aspects in the fight against the pathogen, useful in designing public health strategies, vaccines and therapeutic approaches. One of the first pieces of evidence characterizing the SARS‐CoV‐2 infection has been its breadth of clinical presentation, ranging from asymptomatic to severe/deadly disease, and the indication of the key role played by the immune response in influencing disease severity. This review is aimed at summarizing what the SARS‐CoV‐2 infection taught us about the immune response, highlighting its features of a double‐edged sword mediating both protective and pathogenic processes. We will discuss the protective role of soluble and cellular innate immunity and the detrimental power of a hyper‐inflammation‐shaped immune response, resulting in tissue injury and immunothrombotic events. We will review the importance of B‐ and T‐cell immunity in reducing the clinical severity and their ability to cross‐recognize viral variants.
Bubble rise in molten glasses and silicate melts during heating and cooling cycles
Authors: Jackson Lucy E. , Wadsworth Fabian B. , Mitchell Joanne , Rennie Colin , Llewellin Edward W. , Hess Kai‐Uwe , Dingwell Donald B. 
Published: August 2022

AbstractThe Hadamard–Rybczynski equation describes the steady‐state buoyant rise velocity of an unconfined spherical bubble in a viscous liquid. This solution has been experimentally validated for the case where the liquid viscosity is held constant. Here, we extend this result for non‐isothermal conditions, by developing a solution for bubble position in which we account for the time‐dependent liquid viscosity, liquid and gas densities, and bubble radius. We validate this solution using experiments in which spherical bubbles are created in a molten silicate liquid by cutting gas cavities into glass sheets, which are stacked, then heated through the glass transition interval. The bubble‐bearing liquid, which has a strongly temperature‐dependent viscosity, is subjected to various heating and cooling programs such that the bubble rise velocity varies through the experiment. We find that our predictions match the final observed position of the bubble measured in blocks of cooled glass to within the experimental uncertainty, even after the application of a complex temperature–time pathway. We explore applications of this solution for industrial, artistic, and natural volcanological applied problems.
Effect of ζ‐Ta4C3−xon the mechanical properties of tantalum carbide at elevated temperatures
Authors: Schwind Evan C. , Fahrenholtz Bill , Watts Jeremy , Hilmas Greg 
Published: August 2022

AbstractTantalum carbide ceramics containing at least 75‐wt% ζ‐Ta4C3−xwere synthesized and densified to ∼99% of the theoretical density. Flexural strength in four‐point bending was measured from room temperature up to 1600°C, achieving strengths of 710 ± 36.5 MPa at room temperature and decreasing to 180 ± 19.7 MPa at 1600°C. Fracture toughness was measured via the chevron notch method from room temperature up to 1600°C, with a toughness of 10.2 ± 0.4 MPa m1/2at room temperature and decreasing to 4.7 ± 0.1 MPa m1/2at 1600°C. At 1600°C, ductile behavior was observed during testing, and mixed mode fracture was observed on all fracture surfaces. Vickers indentations were used at room temperature to damage the surface of specimens and shed some light on damage mechanisms in the material. Kinking and delamination were observed around the indentations. At elevated temperatures, these deformation mechanisms may activate more often, causing a decrease in strength and resulting in ductility between 1400 and 1600°C. The Griffith analysis was also used to identify critical flaws. The long axis of high aspect ratio grains appears to be the critical flaw from room temperature up to 1400°C, prior to any ductile behavior. Overall, the nanolaminate microstructures, and the kinking and delamination deformation mechanisms that result from it, are reminiscent of MAX phase and kinking nonlinear elastic materials.
The chromatin remodeler BRAHMA recruits HISTONE DEACETYLASE6 to regulate root growth inhibition in response to phosphate starvation in Arabidopsis
Authors: Li Tao , Zhang Ruyue , Satheesh Viswanathan , Wang Peng , Ma Guojie , Guo Jianfei , An Guo‐Yong , Lei Mingguang 
Published: August 2022

AbstractPlasticity in root system architecture (RSA) allows plants to adapt to changing nutritional status in the soil. Phosphorus availability is a major determinant of crop yield, and RSA remodeling is critical to increasing the efficiency of phosphorus acquisition. Although substantial progress has been made in understanding the signaling mechanism driving phosphate starvation responses in plants, whether and how epigenetic regulatory mechanisms contribute is poorly understood. Here, we report that the Switch defective/sucrose non‐fermentable (SWI/SNF) ATPase BRAHMA (BRM) is involved in the local response to phosphate (Pi) starvation. The loss of BRM function induces iron (Fe) accumulation through increased LOW PHOSPHATE ROOT1 (LPR1) and LPR2 expression, reducing primary root length under Pi deficiency. We also demonstrate that BRM recruits the histone deacetylase (HDA) complex HDA6‐HDC1 to facilitate histone H3 deacetylation at LPR loci, thereby negatively regulating local Pi deficiency responses. BRM is degraded under Pi deficiency conditions through the 26 S proteasome pathway, leading to increased histone H3 acetylation at the LPR loci. Collectively, our data suggest that the chromatin remodeler BRM, in concert with HDA6, negatively regulates Fe‐dependent local Pi starvation responses by transcriptionally repressing the RSA‐related genes LPR1 and LPR2 in Arabidopsis thaliana.
Optimising the educational value of indirect patient care
Authors: O'Toole Danielle , Sadik Marina , Inglis Gabrielle , Weresch Justin , Vanstone Meredith 
Published: August 2022

AbstractIntroductionIndirect patient care activities (IPCA) such as documentation, reviewing investigations and filling out forms require an increasing amount of physician time. While an essential part of patient care, rising rates of IPCA work correspond with increases in physician burnout and job dissatisfaction. It is not known how best to prepare residents in IPCA‐heavy specialties (e.g. family medicine) for this aspect of their career. This study investigates how educators and residency programmes can optimise IPCA work during residency to best prepare residents for future practice.MethodsUsing Constructivist Grounded Theory, we conducted focus groups and individual interviews with 42 clinicians (19 family medicine residents, 16 family physicians in the first 5 years of practice and 7 family physician educators). All participants were connected to one family medicine residency programme. We analysed interview data iteratively, using a staged approach to constant comparative analysis.ResultsWhile residents, early career physicians and educators perceived the educational value of IPCAs differently, they all reported IPCAs as a necessary weight that family physicians carry throughout their career. Some residents described IPCAs as a burden, creating inequities in workload and interfering with other learning and personal opportunities. In contrast, educators conceptualised IPCAs as an opportunity to build and develop the skills required to carry the weight of IPCAs throughout their career. We make specific recommendations for helping residents recognise this educational opportunity, such as clarifying expectations, navigating equity, understanding purpose and maintaining consistency when teaching IPCAs.ConclusionIPCAs are a key competency for many medical residents but require explicit pedagogical attention. If the educational opportunities are not made explicit, residents may miss the opportunity to develop strategies for practice management, professional boundaries, and administrative efficiencies.
Phylogenomic structure and speciation in an emerging model: the Sphagnum magellanicum complex (Bryophyta)
Authors: Shaw A. Jonathan , Piatkowski Bryan , Duffy Aaron M. , Aguero Blanka , Imwattana Karn , Nieto‐Lugilde Marta , Healey Adam , Weston David J. , Patel Megan N. , Schmutz Jeremy , Grimwood Jane , Yavitt Joseph B. , Hassel Kristian , Stenøien Hans K. , Flatberg Kjell‐Ivar , Bickford Christopher P. , Hicks Karen A. 
Published: August 2022

Summary

Sphagnum magellanicum is one of two Sphagnum species for which a reference‐quality genome exists to facilitate research in ecological genomics.

Phylogenetic and comparative genomic analyses were conducted based on resequencing data from 48 samples and RADseq analyses based on 187 samples.

We report herein that there are four clades/species within the S. magellanicum complex in eastern North America and that the reference genome belongs to Sphagnum divinum. The species exhibit tens of thousands (RADseq) to millions (resequencing) of fixed nucleotide differences. Two species, however, referred to informally as S. diabolicum and S. magni because they have not been formally described, are differentiated by only 100 (RADseq) to 1000 (resequencing) of differences. Introgression among species in the complex is demonstrated using D‐statistics and f4 ratios. One ecologically important functional trait, tissue decomposability, which underlies peat (carbon) accumulation, does not differ between segregates in the S. magellanicum complex, although previous research showed that many closely related Sphagnum species have evolved differences in decomposability/carbon sequestration.

Phylogenetic resolution and more accurate species delimitation in the S. magellanicum complex substantially increase the value of this group for studying the early evolutionary stages of climate adaptation and ecological evolution more broadly.
Understanding the organizational learning culture—Innovative behavior relation in local government: The roles of knowledge sharing and job autonomy
Authors: Lee Jaeyong , Jin Myung H. 
Published: August 2022

AbstractDrawing from research on organizational learning culture, knowledge sharing (KS), and job characteristics theory, this study investigates the mediating role of KS in the link between organizational learning culture (OLC) and employee's innovative behavior (IB), as well as how this mediating effect might be moderated by job autonomy (JA). Data captured from 1420 public employees of 33 local governments in South Korea shows that OLC affects employees' IB, while the effect size is reduced when controlling for the role of KS. Further, JA moderates the positive relationship between KS and IB, such that the relationship becomes invigorated at higher levels of JA. The findings also reveal that the indirect effect of OLC on IB through KS is more pronounced at higher levels of JA, which offers evidence of moderated mediation. We discuss the significant implications of our findings for future research and practice.
Public health in undergraduate nursing education and workforce readiness
Authors: Schofield Ruth , Chircop Andrea , Filice Sylvane , Filion Francoise , Lalonde Shona , Riselli Dawn Mercer , Ryan Maureen M. , Vukic Adele 
Published: August 2022

AbstractStudent engagement with the community is a cornerstone of undergraduate nursing education in Canada. Working with community from perspectives of social justice, health equity, advocacy, and political action are essential for workforce readiness. We suggest that the erosion of public health theory and clinical courses in baccalaureate nursing programs undermines the potential capability of nurses to address the intersectionality of the social determinants of health. The impact of the COVID‐19 pandemic on populations further demonstrates inequities, particularly among marginalized populations. Public health nursing education supports students’ understanding about the health impacts of social injustice, how systemic racism is embedded in colonial and Eurocentric structures, and practices of superiority and privileges.We, as a national group of public health nursing educators, set out to investigate how existing guidelines and competencies support public health in undergraduate education across Canada. Results from a national questionnaire of educators, and of PHN leaders on new graduate practice readiness are presented. Questionnaire responses confirm an erosion of PHN theory and practice in baccalaureate nursing education (BNE) curricula. The results of the questionnaires combined with evidence of PHN since the global pandemic provide educators and practitioners more insight to inform future directions to respond to workforce readiness.
Photolabile Protecting Groups Based on the Excited State Meta Effect: Development and Application†
Authors: Wang Pengfei , Lim Chaeeun 
Published: August 2022

AbstractThis review focuses on utilization of the excited state meta effect (ESME) in the development of photolabile protecting groups (PPGs). Structurally simple ESME‐based PPGs for release of various functional groups (such as carbonyl, hydroxyl, carboxyl, amino and thiol groups) are discussed. Examples that demonstrate the appealing advantages of these new PPGs are provided, including their efficient release of “poor” leaving groups such as hydroxyl or amino group directly instead of in their respective carbonate or carbamate form. Applications of these PPGs in synthesis, release of biologically important molecules, materials science and biomedical engineering are also described.
Pan-Cancer Analysis of Microbiome Quantitative Trait Loci
Authors: Chen Can , Cai Yimin , Liu Yizhuo , Chen Shuoni , Li Yanmin , Zhang Fuwei , Zhang Ming , Lu Zequn , Ying Pingting , Huang Jinyu , Fan Linyun , Cai Xiaomin , Ning Caibo , Wang Wenzhuo , Jiang Yuan , Zhang Heng , Yang Shuhui , Wang Zhihua , Wang Xiaoyang , Zhang Shaokai , Huang Chaoqun , Xu Bin , Fu Zhenming , Song Qibin , Jin Mingjuan , Chen Kun , Chen Hongda , Dai Min , Miao Xiaoping , Yang Xiaojun , Zhu Ying , Tian Jianbo 
Published: August 2022

Abstract

Microorganisms are commonly detected in tumor tissues, and the species and abundance have been reported to affect cancer initiation, progression, and therapy. Host genetics have been associated with gut microbial abundances, while the relationships between genetic variants and the cancer microbiome still require systematic interrogation. Therefore, identification of cancer microbiome quantitative trait loci (mbQTL) across cancer types might elucidate the contributions of genetic variants to tumor development. Using genotype data from The Cancer Genome Atlas and microbial abundance levels from Kraken-derived data, we developed a computational pipeline to identify mbQTLs in 32 cancer types. This study systematically identified 38,660 mbQTLs across cancers, ranging 50 in endometrial carcinoma to 3,133 in thyroid carcinoma. Furthermore, a strong enrichment of mbQTLs was observed among transcription factor binding sites and chromatin regulatory elements, such as H3K27ac. Notably, mbQTLs were significantly enriched in cancer genome-wide association studies (GWAS) loci and explained an average of 2% for cancer heritability, indicating that mbQTLs could provide additional insights into cancer etiology. Correspondingly, 24,443 mbQTLs overlapping with GWAS linkage disequilibrium regions were identified. Survival analyses identified 318 mbQTLs associated with patient overall survival. Moreover, we uncovered 135,248 microbiome–immune infiltration associations and 166,603 microbiome–drug response associations that might provide clues for microbiome-based biomarkers. Finally, a user-friendly database, Cancer-mbQTL (http://canmbqtl.whu.edu.cn/#/), was constructed for users to browse, search, and download data of interest. This study provides a valuable resource for investigating the roles of genetics and microorganisms in human cancer.

Significance:
This study provides insights into the host–microbiome interactions for multiple cancer types, which could help the research community understand the effects of inherited variants in tumorigenesis and development.