bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrospun non-wovens potential wound dressing material based on polyacrylonitrile/chicken feathers keratin nanofiber
Authors: Serag Eman , El-Aziz Asmaa M. Abd , El-Maghraby Azza , Taha Nahla A. 
Published: September 2022

AbstractElectrospinning nanofibers have a tremendous interest in biomedical applications such as tissue engineering, drug administration, and wound healing because of their ability to replicate and restore the function of the natural extracellular matrix found in tissues. The study’s highlight is the electrospinning preparation and characterization of polyacrylonitrile with chicken feather keratin as an additive. In this study, keratin was extracted from chicken feather waste using an environmentally friendly method and used to reinforce polymeric nanofiber mats. Scanning electron microscopy, energy dispersive spectroscopy, and transmission electron microscopy were used to examine the morphology and the structure of the prepared nanofiber mats. The effect of keratin on the porosity and the tensile strength of reinforcing nanofibers is investigated. The porosity ratio of the nanofiber mats goes up from 24.52 ± 2.12 for blank polyacrylonitrile (PAN (NF)) to 90.89 ± 1.91% for polyacrylonitrile nanofiber with 0.05 wt% keratin (PAN/0.05% K). Furthermore, keratin reinforcement improves the nanofiber's mechanical properties, which are important for wound dressing application, as well as its antibacterial activity without causing hemolysis (less than 2%). The best antibacterial activities were observed against Pseudomonas aeruginosa (30 ± 0.17 mm inhibition zone) and Staphylococcus aureus (29 ± 0.31 mm inhibition zone) for PAN/0.05% K sample, according to the antibacterial test. This research has a good potential to broaden the use of feather keratin-based nanofibers in wound healing.
SARS-CoV-2 specific T cell and humoral immune responses upon vaccination with BNT162b2: a 9 months longitudinal study
Authors: Takeuchi Junko S. , Fukunaga Ami , Yamamoto Shohei , Tanaka Akihito , Matsuda Kouki , Kimura Moto , Kamikawa Azusa , Kito Yumiko , Maeda Kenji , Ueda Gohzoh , Mizoue Tetsuya , Ujiie Mugen , Mitsuya Hiroaki , Ohmagari Norio , Sugiura Wataru 
Published: September 2022

AbstractThe humoral and cellular immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon the coronavirus disease 2019 (COVID-19) vaccination remain to be clarified. Hence, we aimed to investigate the long-term chronological changes in SARS-CoV-2 specific IgG antibody, neutralizing antibody, and T cell responses during and after receiving the BNT162b2 vaccine. We performed serological, neutralization, and T cell assays among 100 hospital workers aged 22–73 years who received the vaccine. We conducted seven surveys up to 8 months after the second vaccination dose. SARS-CoV-2 spike protein-specific IgG (IgG-S) titers and T cell responses increased significantly following the first vaccination dose. The highest titers were observed on day 29 and decreased gradually until the end of the follow-up period. There was no correlation between IgG-S and T cell responses. Notably, T cell responses were detected on day 15, earlier than the onset of neutralizing activity. This study demonstrated that both IgG-S and T cell responses were detected before acquiring sufficient levels of SARS-CoV-2 neutralizing antibodies. These immune responses are sustained for approximately 6 to 10 weeks but not for 7 months or later following the second vaccination, indicating the need for the booster dose (i.e., third vaccination).
The neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting
Authors: Ishikawa Masashi , Iwasaki Masae , Namizato Dai , Yamamoto Makiko , Morita Tomonori , Ishii Yosuke , Sakamoto Atsuhiro 
Published: September 2022

AbstractPostoperative acute kidney injury (AKI) is a highly prevalent and serious complication after cardiac surgery. The aim of this study is to identify the predictors of AKI and the cut-off values after isolated off-pump coronary artery bypass grafting (OPCAB). A total of 329 adult patients, who underwent isolated OPCAB between December 2008 and February 2021, were retrospectively analyzed. The patients were divided into three groups: non-AKI, early AKI and late AKI groups. The early AKI group or the late AKI group were defined as ‘having AKI that occurred before or after 48 h postoperatively’, respectively. Multivariate logistic regression analysis was performed to identify the predictors of AKI. Receiver operating characteristic (ROC) curve analysis was used to evaluate the cutoff value, the sensitivity, and the specificity of the predictors. On the multivariate analysis, the emergency surgery, the preoperative serum albumin, and the postoperative day 1 neutrophil to lymphocyte ratio (NL ratio) were identified as the independent predictors of AKI. However, neither albumin nor the NL ratio predicted late AKI. The present study showed the preoperative albumin and the postoperative day 1 NL ratio were the robust and independent predictors of postoperative early AKI in isolated OPCAB.
Adsorption of ice-binding proteins onto whole ice crystal surfaces does not necessarily confer a high thermal hysteresis activity
Authors: Arai Tatsuya , Yamauchi Akari , Yang Yue , Singh Shiv Mohan , Sasaki Yuji C. , Tsuda Sakae 
Published: September 2022

AbstractMany psychrophilic microorganisms synthesize ice-binding proteins (IBPs) to survive the cold. The functions of IBPs are evaluated by the effect of the proteins on the nonequilibrium water freezing-point depression, which is called “thermal hysteresis (TH)”, and the inhibitory effect of the proteins on the growth of larger ice crystals, which is called “ice recrystallization inhibition (IRI)”. To obtain mechanical insight into the two activities, we developed a modified method of ice affinity purification and extracted two new IBP isoforms from Psychromyces glacialis, an Arctic glacier fungus. One isoform was found to be an approximately 25 kDa protein (PsgIBP_S), while the other is a 28 kDa larger protein (PsgIBP_L) that forms an intermolecular dimer. Their TH activities were less than 1 °C at millimolar concentrations, implying that both isoforms are moderately active but not hyperactive IBP species. It further appeared that both isoforms exhibit high IRI activity even at submicromolar concentrations. Furthermore, the isoforms can bind to the whole surface of a hemispherical single ice crystal, although such ice-binding was generally observed for hyperactive IBP species. These results suggest that the binding ability of IBPs to whole ice crystal surfaces is deficient for hyperactivity but is crucial for significant IRI activity.
Synthesis of vacancy-rich titania particles suitable for the additive manufacturing of ceramics
Authors: Benavides-Guerrero Jaime A. , Gerlein Luis Felipe , Trudeau Charles , Banerjee Debika , Guo Xiaohang , Cloutier Sylvain G. 
Published: September 2022

AbstractIn the last decades, titania (or TiO2) particles played a crucial role in the development of photo-catalysis and better environmentally-friendly energy-harvesting techniques. In this work, we engineer a new generation of TiO2 particles rich in oxygen vacancies using a modified sol–gel synthesis. By design, these vacancy-rich particles efficiently absorb visible light to allow carefully-controlled light-induced conversion to the anatase or rutile crystalline phases. FTIR and micro-Raman spectroscopy reveal the formation of oxygen vacancies during conversion and explain this unique laser-assisted crystallization mechanism. We achieve low-energy laser-assisted crystallization in ambient environment using a modified filament 3D printer equipped with a low-power laser printhead. Since the established high-temperature treatment necessary to convert to crystalline TiO2 is ill-suited to additive manufacturing platforms, this work removes a major fundamental hurdle and opens whole new vistas of possibilities towards the additive manufacturing of ceramics, including carefully-engineered crystalline TiO2 substrates with potential applications for new and better photo-catalysis, fuel cells and energy-harvesting technologies.
Ficus dubia latex extract prevent DMH-induced rat early colorectal carcinogenesis through the regulation of xenobiotic metabolism, inflammation, cell proliferation and apoptosis
Authors: Hu Rentong , Chantana Weerachai , Pitchakarn Pornsiri , Subhawa Subhawat , Chantarasuwan Bhanumas , Temviriyanukul Piya , Chewonarin Teera 
Published: September 2022

AbstractFicus dubia latex is recognized as a remedy in Asian traditional medicine with various therapeutic effects. The present study aimed to determine the preventive action of Ficus dubia latex extract (FDLE) on 1,2-dimethylhydrazine (DMH)-induced rat colorectal carcinogenesis and its mechanisms. The experiment included an initiation model in which rats were orally administered with FDLE daily for 1 week before DMH injection until the end of the experiment, while only after DMH injection until the end in the post-initiation model. The results firstly indicated that FDLE treatment could reduce the level of methylazoxymethanol (MAM) in rat colonic lumen by inhibition of the activities of both phase I xenobiotic metabolizing enzymes in the liver and β-glucuronidase in the colon, leading to reduced DNA methylation in colonic mucosal cells, related to the number of ACF in the initiation stage. Besides, FDLE modulated the inflammation which could suppress the growth and induce apoptosis of aberrant colonic mucosal cells, leading to retardation of ACF multiplicity. Therefore, FDLE showed the ability to suppress the DMH-induced rat ACF formation and inflammation promoted growth of ACF. In conclusion, FDLE had the potential to prevent carcinogens-induced rat colorectal carcinogenesis in the initiation stage.
Did Changes to Adult Hearing Aid Pathways Due to COVID-19 Affect Patient Outcomes? A Service Evaluation
Authors: Duckworth Zoe , Beckman Adam , Heinrich Antje 
Published: September 2022

Objective:
The objective of this study was to determine whether changes to adult hearing aid provision during COVID-19 affected patient outcomes or service efficiency.

Design:
A service evaluation compared three cohorts: patients who had hearing aid provision prior to the COVID-19 pandemic (the conventional pathway); patients who had hearing aid provision during the initial national lockdown (remote fittings); and patients who had hearing aid provision during the gradual reopening phase (a blended service with both face-to-face and remote service provision). Outcomes measured the effectiveness and efficiency of the service, using the Glasgow Hearing Aid Benefit/Difference Profiles (GHABP/DP) and number of follow-up appointments required. Results were assessed using descriptive statistics and error bars, separately for new and existing users.

Sample:
This study included 240 hearing aid users.

Results:
Remote fittings adversely impacted the effectiveness of provision for new hearing aid users with a reduction in all GHABP domains. While new users' benefit was equally as good for blended and conventional service provision, blended provision was less efficient and required more follow-up visits. For existing hearing aid users, no differences were seen in GHADP outcomes of different pathways and remote fittings increased service efficiency.

Conclusions:
Remote hearing aid fittings are less effective for new users than hearing aids fitted using standard face-to-face service provision or service provision using a blended model of remote and face-to-face care. Current pathways using a blended model of care are less efficient but equally effective for new hearing aid users compared with provision prior to COVID-19 and result in equivalent patient outcomes in terms of benefit.

Supplemental Material:

https://doi.org/10.23641/asha.21067585
CDFM: A cross‐domain few‐shot model for marine plankton classification
Authors: Guo Jin , Li Wengen , Guan Jihong , Gao Hang , Liu Baobo , Gong Lili 
Published: September 2022

AbstractMarine plankton classification is important for monitoring marine biological populations and understanding marine ecosystems. However, it is difficult to obtain abundant annotated image data of marine plankton to train classification models of high quality. To classify marine plankton with a small number of image samples, a cross‐domain few‐shot learning model (CDFM) is proposed. First, CDFM learns knowledge from existing labelled images and then transfers the knowledge to new images. In this process, there is an issue of domain differences between the new images and the existing datasets due to differences in data acquisition time and locations. To address this issue, the authors pre‐train a model in the source domain and then use fine‐tuning to adapt it to the target domain. Second, the graph neural network is used as a meta‐learning module to learn a feature distance metric for marine plankton classification with limited samples. Extensive experiments on four marine plankton image datasets are conducted, including Kaggle Plankton, miniPPlankton, ZooScan and WHOI, and CDFM outperforms existing methods for marine plankton classification.
Optimal quantised bits for estimation over a capacity and power limited, lossy channel
Authors: Akumalla Venkatareddy , Khan Mohammed Zafar Ali 
Published: September 2022

AbstractThis letter considers the problem of estimating the state of a scalar dynamical system over a wireless channel that is lossy, capacity, and power limited. The limited power assumption, which is valid for most real problems, links the number of quantisation bits and packet error rate. As the number of quantisation bits increases, the quantisation noise decreases but the packet loss rate increases. It is shown that the estimation error variance (EEV) is minimised for a range of quantisation bits. Further, it is shown that operating beyond the optimal range sharply increases the EEV. Simulation results corroborating the analytical results are also presented.
Identifying and correcting the errors of vehicle trajectories from roadside millimetre‐wave radars
Authors: Lei Cailin , Zhao Cong , Ji Yuxiong , Shen Yu , Du Yuchuan 
Published: September 2022

AbstractMillimetre‐wave (MMW) radars have been increasingly deployed along the roadside highways to collect vehicle trajectory data, which are valuable for traffic safety analyses and traffic control decisions. Nevertheless, possible errors of the trajectories resulting from roadside MMW radars have not been well documented. This study scrutinizes roadside MMW radar data and the concurrent video ground truth to identify five typical errors of vehicle trajectories, including different vehicles tagged with the same ID, different trajectories produced by the same vehicle, ghost vehicles, erroneous vehicle classification, and vehicle location drift. Data cleaning methods were developed to identify and correct these errors. The performance of the developed methods was evaluated empirically in a case study based on the data of five radars, which were installed at different locations along the highway and had different headings. The thresholds of the developed method were calibrated using one radar data and then applied to the data of the five radars. The results showed that the data qualities of all radars are greatly improved by the developed methods, demonstrating that the developed methods are generally applicable for cleaning vehicle trajectory data from roadside MMW radars.
La mémoire insupportable
Authors: Givord-Bartoli Augustin 
Published: September 2022

Aujourd’hui, les troubles de la mémoire s’installent dans nos pratiques et notre questionnement. S’il nous paraît logique de lier ce phénomène à celui du vieillissement global de la population, une observation approfondie ouvre le champ d’une réflexion au-delà du seul sujet âgé. L’approche ici proposée part d’un trouble mémoriel déclaré sur le tard, pour mieux expliquer l’organisation de la mémoire depuis sa formation. Il s’agit de traiter les éléments manifestes en tant que signes structurels.
Ainsi, les désordres de la mémoire révèlent la trame inconsciente du sujet, et nous aident à penser son inscription psychique. Ceci au sein d’un monde où les technologies d’assistance à l’être humain, via l’informatique et la robotique principalement, sont en plein essor... au risque de croire en une science idéale, capable de biaiser tous nos insupportables.
Face validity of a virtual reality simulation platform to improve competency in endoscopy: a prospective observational cohort study
Authors: Eley Catherine , Hawkes Neil D , Egan Richard J , Robinson David B , Brown Chris , Murray Sam , Siau Keith , Lewis Wyn 
Published: September 2022

Abstract
Background and study aims Virtual reality endoscopic simulation training has the potential to expedite competency development in novice trainees. However, simulation platforms must be realistic and confer face validity. This study aimed to determine the face validity of high-fidelity virtual reality simulation (EndoSim, Surgical Science, Gothenburg), and establish benchmark metrics to guide the development of a Simulation Pathway to Improve Competency in Endoscopy (SPICE).
Methods A pilot cohort of four experts rated simulated exercises (Likert scale score 1–5) and following iterative development, 10 experts completed 13 simulator-based endoscopy exercises amounting to 859 total metric values.
Results Expert metric performance demonstrated equivalence (P = 0.992). In contrast, face validity of each exercise varied among experts (median 4 (interquartile range [IQR] 3–5), P < 0.003) with Mucosal Examination receiving the highest scores (median 5 [IQR 4.5–5], P = 1.000) and Loop Management and Intubation exercises receiving the lowest scores (median 3 [IQR 1–3], P < 0.001, P = 0.004), respectively. The provisional validated SPICE comprised 13 exercises with pass marks and allowance buffers defined by median and IQR expert performance.
Conclusions EndoSim Face Validity was very good related to early scope handling skills, but more advanced competencies and translation of acquired clinical skills require further research within an established training program. The existing training deficit with superadded adverse effects of the COVID pandemic make this initiative an urgent priority.
Underwater endoscopic submucosal dissection and hybrid endoscopic submucosal dissection as rescue therapy in difficult colorectal cases
Authors: Cecinato Paolo , Lucarini Matteo , Campanale Chiara , Azzolini Francesco , Bassi Fabio , Sassatelli Romano 
Published: September 2022

Abstract
Background and study aims Colorectal endoscopic submucosal dissection (ESD) is still not widely used due to its technical difficulty and the risk of complications. Rescue therapies such as hybrid ESD (H-ESD) have been proposed for very difficult cases, as has underwater ESD (U-ESD). This study evaluated the safety and efficacy of H-ESD and U-ESD in difficult cases.
Patients and methods The hospital charts of consecutive patients referred for colorectal ESD between January 2014 and February 2021 because they were considered difficult cases were retrospectively analyzed. The primary outcome of the study was en bloc resection rate; secondary outcomes were the rate of complete resection, procedure speed, and incidence of adverse events (AEs).
Results Fifty-nine colorectal neoplasms were considered, 22 of which were removed by U-ESD and 37 by H-ESD. The en bloc resection rate in the U-ESD group was 100 %, while it was 59.5 % in the H-ESD group. Dissection speed was 17.7mm2/min in the U-ESD group and 8.3 mm2/min in the H-ESD group. The AE rate was low in the U-ESD group and moderately high during H-ESD (5 % and 21.6 %, respectively; and perforation rate 0 % and 10.8 %, respectively). Larger lesions were treated with U-ESD, while more fibrotic ones were treated with H-ESD.
Conclusions U-ESD and H-ESD are both effective and safe techniques in difficult colorectal situations. U-ESD is particularly effective and fast for large lesions when it is not possible to obtain comfortable knife position, while H-ESD is more suitable for very fibrotic lesions.
Educational interventions to improve ergonomics in gastrointestinal endoscopy: a systematic review
Authors: Shergill Amandeep K. , Grover Samir C. , Scaffidi Michael A. , Gimpaya Nikko , Fecso Andras B. , Khan Rishad , Li Juana , Bansal Rishi , Torabi Nazi 
Published: September 2022

Abstract
Background and study aims Endoscopists are at high risk of musculoskeletal pain and injuries (MSPI). Recently, ergonomics has emerged as an area of interest to reduce and prevent the incidence of MSPI in endoscopy. The aim of this systematic review was to determine educational interventions using ergonomic strategies that target reduction of endoscopist MSPI from gastrointestinal endoscopy.
Methods In December 2020, we conducted a systematic search in MEDLINE, EMBASE, PsycINFO, Web of Science, Scopus, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews for articles published from inception to December 16, 2020. Studies were included if they investigated educational interventions aimed at changing knowledge and/or behaviors related to ergonomics in gastrointestinal endoscopy. After screening and full-text review, we extracted data on study design, participants, type of training, and assessment of primary outcomes. We evaluated study quality with the Medical Education Research Study Quality Instrument (MERSQI).
Results Of the initial 575 records identified in the search, five met inclusion criteria for qualitative synthesis. We found that most studies (n = 4/5, 80 %) were single-arm interventional studies that were conducted in simulated and/or clinical settings. The most common types of interventions were didactic sessions and/or videos (n = 4/5, 80%). Two (40 %) studies used both standardized assessment studies and formal statistical analyses. The mean MERSQI score was 9.7.
Conclusions There is emerging literature demonstrating the effectiveness of interventions to improve ergonomics in gastrointestinal endoscopy.
Angiosarcoma on Top of a Meningioma Mimicking a Transosseous Meningioma: an Interdisciplinary Point of View
Authors: Kohl Jana , König Rebecca E , Kraus Armin , Mawrin Christian , Paukisch Harald , Stein Klaus-Peter , Rashidi Ali , Luchtmann Michael , Sandalcioglu I Erol , Lilla Nadine 
Published: September 2022

AbstractCutaneous angiosarcoma is a rare type of sarcoma with poor prognosis. Meningioma is the most frequent benign intracranial tumor. Despite the fact that meningiomas are mostly benign, bone and skin can be infiltrated. We report the rare case of an angiosarcoma on top of a meningioma with hyperostosis at exactly the same location mimicking a transosseous growth of a meningioma. An 84-year-old man presented with progressive swelling and ulcerous lesion of the forehead. The patient underwent surgery in an interdisciplinary setting together with a plastic surgeon, including resection of the intracranial tumor and infiltrated bone and skin. To the best of our knowledge, this is the only reported case of a meningioma and angiosarcoma in direct neighborhood. A preoperative biopsy of the skin tumor would have led initially to the correct diagnosis of an angiosarcoma and would have allowed a better planning of the operation and extent of resection.