bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coadministration of CD19- and CD22-Directed Chimeric Antigen Receptor T-Cell Therapy in Childhood B-Cell Acute Lymphoblastic Leukemia: A Single-Arm, Multicenter, Phase II Trial
Authors: Wang Tianyi , Tang Yanjing , Cai Jiaoyang , Wan Xinyu , Hu Shaoyan , Lu Xiaoxi , Xie Zhiwei , Qiao Xiaohong , Jiang Hui , Shao Jingbo , Yang Fan , Ren Hong , Cao Qing , Qian Juan , Zhang Jian , An Kang , Wang Jianmin , Luo Chengjuan , Liang Huanhuan , Miao Yan , Ma Yani , Wang Xiang , Ding Lixia , Song Lili , He Hailong , Shi Wenhua , Xiao Peifang , Yang Xiaomin , Yang Jing , Li Wenjie , Zhu Yiping , Wang Ningling , Gu Longjun , Chen Qimin , Tang Jingyan , Yang Jun J. , Cheng Cheng , Leung Wing , Chen Jing , Lu Jun , Li Benshang , Pui Ching-Hon 
Published: November 2022

PURPOSE We determined the safety and efficacy of coadministration of CD19- and CD22-chimeric antigen receptor (CAR) T cells in patients with refractory disease or high-risk hematologic or isolated extramedullary relapse of B-acute lymphoblastic leukemia. PATIENTS AND METHODS This phase II trial enrolled 225 evaluable patients age ≤ 20 years between September 17, 2019, and December 31, 2021. We first conducted a safety run-in stage to determine the recommended dose. After interim analysis of the first 30 patients treated (27 at the recommended dose) showing that the treatment was safe and effective, the study enrolled additional patients according to the study design. RESULTS Complete remission was achieved in 99.0% of the 194 patients with refractory leukemia or hematologic relapse, all negative for minimal residual disease. Their overall 12-month event-free survival (EFS) was 73.5% (95% CI, 67.3 to 80.3). Relapse occurred in 43 patients (24 with CD19+/CD22+ relapse, 16 CD19–/CD22+, one CD19–/CD22–, and two unknown). Consolidative transplantation and persistent B-cell aplasia at 6 months were associated with favorable outcomes. The 12-month EFS was 85.0% (95% CI, 77.2 to 93.6) for the 78 patients treated with transplantation and 69.2% (95% CI, 60.8 to 78.8) for the 116 nontransplanted patients ( P = .03, time-dependent covariate Cox model). All 25 patients with persistent B-cell aplasia at 6 months remained in remission at 12 months. The 12-month EFS for the 20 patients with isolated testicular relapse was 95.0% (95% CI, 85.9 to 100), and for the 10 patients with isolated CNS relapse, it was 68.6% (95% CI, 44.5 to 100). Cytokine release syndrome developed in 198 (88.0%) patients, and CAR T-cell neurotoxicity in 47 (20.9%), resulting in three deaths. CONCLUSION CD19-/CD22-CAR T-cell therapy achieved relatively durable remission in children with relapsed or refractory B-acute lymphoblastic leukemia, including those with isolated or combined extramedullary relapse. [Media: see text]
Epidemiology of Vitamin D (EpiVida)—A Study of Vitamin D Status Among Healthy Adults in Brazil
Authors: Borba Victoria Zeghbi Cochenski , Lazaretti-Castro Marise , Moreira Sandra da Silva , de Almeida Maria Conceição Chagas , Moreira Edson Duarte 
Published: November 2022

Abstract

Context
There are few studies of 25-hydroxyvitamin D (25(OH)D) concentrations in healthy adults in Brazil.

Objective
This work aimed to estimate the prevalence of vitamin D status and its association with lifestyle, sociodemographic, and anthropometric data in 3 regions of Brazil.

Methods
A cross-sectional study was conducted among blood donors of both sexes, living in the cities of Salvador, São Paulo, and Curitiba during summer. Blood samples were collected during the procedure. Serum 25(OH)D and parathyroid hormone (PTH) were measured in the same laboratory using chemiluminescence immunoassays. Lifestyle, sociodemographic, and anthropometric data were gathered by an interview with a standardized questionnaire. Vitamin D deficiency and insufficiency was defined as 25(OH)D levels below 20 ng/mL and below 30 ng/mL, respectively.

Results
A total of 1004 healthy adults were evaluated with mean levels of 25(OH)D (28.7 ± 9.27 ng/mL) and PTH (34.4 ± 15.1 pg/mL). The standardized prevalence of vitamin D deficiency and insufficiency was in the study population 15.3% and 50.9%: in Salvador 12.1% and 47.6%, in São Paulo 20.5%, and 52.4% and in Curitiba 12.7% and 52.1%, (P = .0004). PTH levels were negatively correlated with 25(OH)D levels. Greater body mass index (BMI) and higher latitude were significant predictors of vitamin D deficiency, whereas skin color (White), longer duration of sun exposure, and current use of dietary supplement were protective.

Conclusion
This study confirmed the high prevalence of vitamin D deficiency and insufficiency even in the midsummer in a healthy population of Brazil. Vitamin D levels are associated with sun exposure, latitude, BMI, skin color, and use of supplements.
Research on factors affecting tourist involvement in coffee tourism after the COVID-19 pandemic in Thailand
Authors: Madhyamapurush Warach 
Published: November 2022

Background: The world economy was broken by the COVID-19 pandemic, which affected the coffee industry. The COVID-19 pandemic's financial effects might influence equity markets and personal lives. This includes financial commodities like coffee, which the pandemic is predicted to damage. Coffee tourism is an emerging new kind of tourism in Thailand, formed in response to growing demand from visitors with a particular affinity for the beverage. Coffee tourism may contribute considerably to the expansion of Thai tourism if given the proper guidance and assistance. Methods: As part of a coffee tourism experience focusing on first-hand activities and information, tourists can visit neighbouring sites while on a coffee plantation. This research uses a stochastic neuro-fuzzy decision tree (SNF-DT) to analyse coffee tourism in Thailand. The research surveys 400 international and Thai coffee tourists. According to studies, Thai visitors mostly visit coffee tourism locations in Thailand for enjoyment. They also wanted to visit coffee fields in order to get personal knowledge of coffee production and marketing. Based on the comments of Thai visitors, coffee tourism in northern Thailand looks to be highly and effectively handled. Due to the same factor, responses from foreign coffee tourists indicated that many of their journeys to coffee tourism destinations were made entirely for enjoyment rather than the business. They also wanted to meet local tour guides and acquire handmade and locally produced things to understand more about coffee tourism. Result: According to study results, coffee tourism management in northern Thailand looks well-received by international tourists. We also compare the suggested model to the traditional one to demonstrate its efficacy. The performance metrics are prediction rate, prediction error, and accuracy. The estimated results for our proposed technique are prediction rate (95%), prediction error (97%), and accuracy (94%).
Granite classification using machine learning and edge computing
Authors: Karanam Madhavi , Nagaraju Krishna Chythanya , P Gotham Sai , S SaiKiran Manasa , G Pranay Krishna 
Published: November 2022

Background: The outlook and the aura of any place are highly dependent on how a place is decorated and what materials are used in designing it. Granite is such a kind of rock which is vastly used for this purpose. Granite flooring and counters have a major influence on the interior d ́ecor which is essential to set the mood and ambience of a house. A system is needed to help the end users differentiate between granites, which enhance the grandeur of their house and also check the frauds of different color granite being sent by the merchant as compared to what was selected by the end user. Several models have been developed for this cause using CNN and other image processing techniques. However, a solution for this purpose must be precise and computationally efficient. Methods: For this purpose,researchers in this work developed a machine learning based granite classifier using Edge Computing and a website to help users in choosing which granite would go well with their d ́ecor is also built. The developed system consists of a color sensor [TCS3200] integrated with an ESP8266 board. The data pertaining to RGB contrasts of different rocks is acquired by using the color sensor from a dealership.This data is used to train a Machine Learning algorithm to classify the rock into different granite types from a granite dealer and yield the category prediction. Results: The proposed system yields a result of 94% accuracy when classified using Random Forest Algorithm. Conclusion: Thus, this system provides an upper hand for the end users in differentiating between different types of granites.
Comparative analysis of computed tomography severity indices in predicting the severity and clinical outcome in patients with acute pancreatitis
Authors: Parmar Geetanjali , Noronha Griselda Philomena , Poornima Vinaya 
Published: November 2022

Background: Acute pancreatitis (AP) has unpredictable severity. Its management is based on initial assessment of disease severity. It ranges from mild interstitial to severe necrotic form; the latter is associated with poor prognosis. Contrast-enhanced computed tomography (CT) of the abdomen is the gold standard in early detection of pancreatic necrosis and in assessing the severity of AP. Two CT grading systems exist to assess severity of AP: CT severity Index (CSI) and modified CSI (MCSI). This study compares the usefulness of these two systems in predicting severity and clinical outcome in AP in comparison with Ranson’s criteria and clinical outcome parameters. Methods: This is a prospective hospital-based screening study of 80 patients aged >12 years with clinical diagnosis of AP who underwent contrast-enhanced CT study of the abdomen. Comparative analysis between MCSI and CSI with Ranson’s criteria and clinical outcome parameters was assessed by Chi-Squared test. Results: The accuracy of CSI and MSCI in predicting the requirement of critical care, superadded infection, multiple organ dysfunction syndrome (MODS) and requirement of intervention were 73.0%, 64.5%, 69.8% 60.9% and 77.2%, 76.0%, 74.4% & 56.6%, respectively. Area under the curve for MCSI score was significantly higher (AUC : 0.861; 95% CI: 0.736-0.986) than CSI score (AUC:0.815;95% CI:0.749-0.941). MCSI and CSI showed significant correlation with Ranson’s criteria; however, MCSI correlation was better (r:0.53; p<0.01) than CSI (r:0.35;p:0.04). Conclusion: CSI and MCSI are better predictors of severity, clinical outcome and mortality compared with Ranson’s criteria, with MCSI being more accurate and better predictor than CSI. The accuracy of MCSI is better than CSI for prediction of requirement of critical care, development of superadded infection and development of MODS in AP. However, CSI and MCSI have low accuracy in predicting intervention in AP.
School learning environment and educational space: features and differences
Authors: Nikolaev V. 
Published: November 2022

The modern school education is aimed at developing students’ personality, forming their traits and skills that can help them to cope with the challenges and changes in the content of education, as well as with educational technological advances (including information technology), forms of interaction (with all subjects of the educational process), new methods and means of education. The ultimate goal is to be ready for further self-realization in the conditions of constant changes in the surrounding society.
The design of a new type of the learning environment that integrates all the resources and capabilities of the school educational space will contribute to achieving the desired goal.
The article considers the features and differences between the concepts "learning environment" and "educational space", and discusses their impact on students. This paper also presents some approaches used to design the learning environment that was developed for the teaching staff of the school-kindergarten Educational Complex "Our School" (Novosibirsk): the mission of the school, the basic principles of organizing the educational space, the main system-forming approaches to the design of the school learning environment.
Nanosecond tunable laser for the all-optical switching network
Authors: Yin Zhiqian , Sun Qi , Liu Zhewen , Wang Yaguang , Wang Leilei , Zhang Yunshan , Zhu Xingbang , Fang Tao , Chen Xiangfei 
Published: November 2022

The optically switched network can offset the increasing gap between datacenter traffic growth and electrical switch capacity due to the slowdown of Moore’s law. Ultra-high-speed wavelength tunable lasers are especially vital for the high integration and performance improvement of the all-optical switching system. In this paper, a fast tunable laser based on a laser array is realized. The2×8matrix structure of the laser array is fabricated by the reconstruction-equivalent-chirp (REC) technique. Aiming at the2×8array, a drive control system is designed to provide stable and fast switching, to achieve high-speed switching of the laser wavelength, and to keep the wavelength stable after switching. The simulation and experimental results show that the switching time between any two wavelength channels of the laser is less than 10 ns. The switching time of any two channels of the laser can be reduced by 2–3 ns after the pre-emphasis processing of the electrical signal.
Hematological parameters of reproductive-age women using hormonal contraceptives at University of Gondar Comprehensive Specialized Referral Hospital, Northwest Ethiopia: A comparative cross-sectional study
Authors: Gedfie Solomon , Getawa Solomon , Kassahun Woldeteklehaymanot , Gashaye Kiros Terefe , Melku Mulugeta 
Published: November 2022

Background
More than one-third of reproductive aged women in Ethiopia use hormonal contraceptives to prevent conception. The present study aimed to compare the hematological parameters of reproductive-age women taking hormonal contraceptives at the University of Gondar Comprehensive Specialized Referral Hospital, Northwest Ethiopia in 2021.

Methods
A comparative cross-sectional study was conducted from April to June 2021. A total of 240 study participants were recruited by using a consecutive sampling technique. Data on socio-demographic variables and clinical data were collected through face-to-face interviews using a structured questionnaire and medical record reviews, respectively. Three milliliter venous blood was collected for complete blood count analysis using Unicel DxH 800 coulter hematology analyzer. Data was entered into Epi-data 4.4.3.1 version then exported to IBM SPSS v25 for analysis. Kruskal-Wallis H, Dunn-Bonferroni pairwise comparison test, and Spearman’s correlation analysis were used for inferential statistics. P<0.05 were considered statistically significant.

Result
The median and interquartile range of platelet count among combined oral contraceptive users was 285(238–332) which is significantly higher than that of depot medroxyprogesterone acetate users 246(220–226) (p = 0.010), implant user 247(221–297) (p = 0.034), and controls 256(224–278) (p = 0.015). The result also showed long-term use of implant negatively correlated with red blood cell count (p = 0.033).

Conclusion
This finding concludes that combined oral contraceptive users had a higher platelet counts than controls while long-term use of implants can result in low red blood cells count. Therefore, a baseline evaluation of complete blood count in women desiring contraceptive methods would also be recommended.
Who Understands Comics? Questioning the Universality of Visual Language Comprehension, Neil Cohn (2020)
Authors: Bateman John A. 
Published: November 2022

Review of: Who Understands Comics? Questioning the Universality of Visual Language Comprehension, Neil Cohn (2020)
London and New York: Bloomsbury Academic, 256 pp.,
ISBN 978-1-35015-604-3, p/bk, £25.99
El curso escolar en tres actos
Authors: Talaya Meseguer María 
Published: November 2022

El presente artículo elabora una propuesta didáctica y metodológica para sexto curso de Educación Primaria. La propuesta consiste en la creación dramática de un cuento-musical, que se desarrollará a lo largo del curso escolar, un proyecto donde la música juega un papel central. Está previsto que este proyecto se lleve a cabo de forma interdisciplinar y transversal, gracias a la metodología del aprendizaje basado en proyectos (ABP). Donde participarán de forma intrínseca, y con un mismo objetivo, todas las áreas que conforman el currículo del sexto curso de Educación Primaria, al que va dirigido la propuesta. Además, en este proyecto intervienen varios tipos de aprendizaje: aprendizaje significativo, aprendizaje vivencial, aprendizaje interdisciplinar, aprendizaje constructivista y aprendizaje colaborativo. Estos suponen una motivación extrínseca para el alumnado y le ayudarán a la construcción de sus propias herramientas y el desarrollo de sus habilidades.
El proyecto que se presenta resulta una propuesta innovadora, tanto como para el área de música, como para la enseñanza interdisciplinar y por proyectos en Educación Primaria. No solamente se busca una mejora de la calidad educativa para los discentes, sino que esta propuesta aspira a redefinir la asignatura de Música en Educación Primaria.
Palabras clave: ABP; interdisciplinariedad; música; motivación; cuento-musical.
Una experiencia audiovisual para los futuros maestros de educación musical
Authors: López Palacios Joaquín , Bravo Marín Raquel , De Moya Martínez María del Valle 
Published: November 2022

La inclusión de recursos audiovisuales ha creado nuevos ambientes de aprendizaje con cambios pedagógicos significativos que obligan a una formación docente en el uso de las TIC. Estos recursos, importante complemento a las explicaciones docentes, resultan motivadores para los estudiantes. Así, la asignatura Expresión Artística de 4º curso del Grado de Maestro en Infantil en la Facultad de Educación de Albacete (UCLM), año académico 2021-22, se enfocó a la creación de un videocuento para desarrollar la creatividad en la expresión plástica y musical y trabajar con diferentes herramientas digitales y pedagógicas: aplicaciones como Movie Maker, Imovie, Adobe Premiere y Spark Vídeo; Power Point o Adobe Acrobat para las presentaciones y recursos específicos como Stop Motion.

Se han aplicado diferentes técnicas artísticas adaptándose a su futura utilización en las aulas de infantil, como el collage, la tampografía o frottage. En el ámbito musical, se ha trabajado la oralidad, paisajes sonoros, leit motive, onomatopeyas y melodías de diferentes periodos y estilos musicales. Así, la unión de tradición y actualidad son un complemento enriquecedor para el alumno, favoreciendo aprendizajes acordes con la digitalización actual. Este uso didáctico de las TIC ofrece a los alumnos la necesaria adaptación tecnológica en las disciplinas artísticas.
Investigation on the inhibitory effects of Zingiber officinale (ginger) and Curcuma longa (turmeric)’s antifungal properties on Rhizopus stolonifer (black bread mould) growth on bread
Authors: Kara Begum 
Published: November 2022

The scope of this research aims to explore effective ways to prevent the bread from moulding for as long as possiblewith the treatment of antifungal herbaceous plants.The research investigates the growth of the fungusRhizopus stoloniferafter theZingiber officinaleandCurcuma longatreatment. This investigationdemonstrates how growth rates of moulds will change against substances with antifungal properties when applied toRhizopus stolonifer,commonly known as black bread mould.
In order to investigate the inhibitory activity of the herbaceous plants with antifungal properties,an experiment with the herb speciesZ. officinaleandC. longa is conducted.For this purpose, the experimental groups under the same circumstances, with an independent variable of two types of plant treatments with fungi-inhibiting properties are compared alongside a control group that shares the same conditions except for the herbaceous plant treatment. Based on the obtained data, an ANOVA statistical test was processed to present acomparison ofthetwo antifungal plant speciesin terms of theireffectiveness in inhibiting fungal growth and reproduction. The investigation aims to bring new perspectives to the biological aspects of a real life problem that most humans encounter in their daily lives.
„Feuergriffel“ – Mannheimer Stadtschreiber für Kinder- und Jugendliteratur
Authors: Harling Bettina 
Published: November 2022

Zusammenfassung
Die Stadtbibliothek Mannheim schreibt seit 2006 alle zwei Jahre ein Stadtschreiber-Stipendium für Kinder- und Jugendbuchautor*innen aus. Drei Monate leben und arbeiten die Preisträger*innen im Turm der Alten Feuerwache. Die Stadtbibliothek sorgt für Begegnungen zwischen den Schreibenden und kleinen und großen Mannheimer*innen. Was als besondere Aktion zum Stadtjubiläum 2007 begann, hat inzwischen einen festen Platz im Kalender der Stadt und mit dem BUNTSTIFT auch noch einen kleinen Bruder bekommen. Hier prämieren Vorschulkinder ihren liebsten Bilderbucherstling.
Zeolitic imidazolate frameworks dispersed in waterborne epoxy resin to improve the anticorrosion performance of the coatings
Authors: Li Li , Cheng Gang , Chen Xuyong 
Published: November 2022

Abstract
Reasonable design of inorganic nano-base materials to promote the anticorrosion performance of waterborne epoxy resin (EP) coating remains a great challenge. Herein, we describe the preparation method and anticorrosion properties of zeolitic imidazolate framework (ZIF-67) composite coatings. ZIF-67 could be used as both anticorrosion filler and pigment for the coatings. The addition of ZIF-67 improved the impermeability of the coating, thus slowing down the chemical reaction on the surface of the substrate. The long-term corrosion-resistant performance of composite coatings (ZIF-67@EP) in 3.5% NaCl solution was evaluated comparatively. Before immersion, the low-frequency impedance of 1% ZIF-67@EP coating was 2.5 times of 0% ZIF-67@EP coating, and after 14 days of immersion, the low-frequency impedance of 1% ZIF-67@EP coating was still 1.8 times of 0% ZIF-67@EP coating. The corrosion rate of 1% ZIF-67@EP coating was decreased by 177 times.
Comprehensive Patent Data of the German Democratic Republic 1949–1990
Authors: Hipp Ann , Fritsch Michael , Greve Maria , Günther Jutta , Lange Marcel , Liutik Christian , Pfeifer Beate , Shkolnykova Mariia , Wyrwich Michael 
Published: November 2022

Abstract
We document the generation and the content of the Comprehensive Patent Database (CPDB) of the German Democratic Republic (GDR) (1949–1990), which is freely available at GESIS https://doi.org/10.7802/2448. The database contains all patents granted in the GDR and published by the Office of Inventions and Patents (later: German Patent and Trade Mark Office/DPMA). The core database covers the years 1950–1990 and contains 24 variables with manually cleaned and processed information on a total of 261,822 unique patents of the GDR.
Rivalry and Philosophy after Deleuze’s Reversal of Platonic Participation
Authors: Butera Steph 
Published: November 2022

Abstract
Deleuze’s reversal of Platonism shifted the traditional emphasis on thinking that which participates in a concept to that in which a claim to participation occurs. The first part of this article presents a reading of this reversal that highlights the implications of Deleuze’s ontology for his non-ontological account of participation, highlighting how this ontology (1) builds on aspects of Plato’s philosophy recovered from beneath the later Platonic tradition of philosophy and (2) supports Deleuze’s account of the rival claims of philosophy and opinion to participate in thought. The second part outlines the difficulties presented by philosophy’s constitutive participation in friendship, love, and rivalry for it to be able to achieve its distinctive task of creating concepts that defeat opinion’s rival claims to address the problems that present themselves to thought.