bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and morphological aspects of neoadjuvant chemotherapy efficacy in patients with aggressive luminal HER2-negative breast cancer
Authors: Morozov D.  A. , Kolyadina I. V. , Poddubnaya I. V. , Ganshina I.  P. , Khokhlova S. V. , Kometova V. V. , Rodionov V. V. 
Published: January 2022

Background. The role of neoadjuvant chemotherapy (NACT) in luminal HER2-negative breast cancer (BC) remains highly controversial due to the lack of reliable predictors of drug therapy efficacy.Objective: to evaluate the effectiveness of NACT in patients with aggressive luminal HER2-negative BC and to compare modern systems for assessing the pathomorphological response.Materials and methods. The tumor response to NACT regimens was assessed in 64 patients with aggressive luminal HER2-negative BC stage II–III. The median age of women was 46.5 years (range 31–76 years), 76.6 % had primary operable stages (cT1–3N0–1), locally advanced BC (cT4, cN2–3) – 23.4 % patients. The characteristics of BC were as follows: invasive ductal carcinoma (76.6 %), grade G2 and G3–54.7 % and 45.3 %, Ki-67 ranged from 20 % to 98 %, median 45 %. The ER expression level was low (1–10 %, ERlow) in 12.5 % and was more than 10 % in 87.5 % of cases. HER2 status corresponded to 0, 1+ and 2+ in the absence of gene amplification – in 50.0 %, 35.9 % and 14.1 % of patients, respectively. The rate of TILs <10 %, 10–20 % and >20 % was in 71.4 %, 10.7 % and 17.9 % of cases. After NACT with the inclusion of anthracyclines and taxanes ± platinum combinations (in BRCA mutated status), the patients underwent radical surgery (mastectomy or breast-conserving surgery) with an assessment of the pathological response.Results. 15.6 % of patients had a complete pathomorphological response (pCR) to treatment, which corresponded to the RCB-0 class and the pathomorphological stage ypT0N0. Residual tumor load with incomplete response was very significant – class RCB-I was noted in only 7.8 %, and RCB-II and RCB-III – in 39.1 % and 37.5 %, respectively. An increase in the size of the residual tumor and the number of affected lymph nodes were associated with an increase in the RCB class. Predictors of pCR achievement in luminal HER2-negative cancer were: grade G3, rare histological forms of BC (medullary, metaplastic), rate of TILs ≥30 %, low ER expression, and HER2 0 status.Conclusion. Assessment of Ki-67, tumor grade, ER and HER2 rate, and TILs before starting NACT will help identify a group of high sensitivity to chemotherapy and optimize the treatment strategy in aggressive luminal HER2-negative BC.
Impact of adjuvant chemotherapy on relapse-free survival of patients with locally advanced cervical cancer
Authors: Smirnova M.  P. , Khadzhimba A. S. , Maksimov S. Ya. , Ilyin A. A. , Pletneva A. V. 
Published: January 2022

Background. In the NCCN guidelines published in 2020, chemoradiation treatment with adjuvant chemotherapy for patients with stage FIGO III cervical cancer was considered counter-productive. Long-term outcomes of treatment for patients with locally advanced disease (IIIC) are still not satisfactory. The desire to change the current situation resulted in the studying of the effectiveness of adjuvant chemotherapy in cervical cancer patients with regional lymph nodes metastases.Objective: to evaluate the effectiveness of the combination of neoadjuvant chemoradiation plus adjuvant chemotherapy in patients with FIGO stage III cervical cancer (T1–2N1M0).Materials and methods. The main group included 119 patients who received chemoradiation followed by adjuvant chemotherapy with cisplatin from 2015 to 2018. The comparison group included 66 patients who received the same combination treatment between 2015 and 2018, however, without adjuvant chemotherapy. Adjuvant chemotherapy did not result in a quality of life reduction. Also, acceptable toxicity was achieved.Results. The follow-up period for patients included in our research was 3 years or more. Recurrences occurred in 32 (27 %) patients in the main group and 31 (47 %) patients in the comparison group. During the first year of follow-up, recurrences occurred in 8 % in the main group and 43 % in a comparison group of patients respectively. There was a difference in the localization of recurrent events. Importantly, no cases of local recurrences were detected.Conclusion. Disease recurrences more often developed in patients of reproductive age and squamous histological type of tumor. Mostly, the progression of the disease was manifested by metastases in the paraaortic lymph nodes. Almost half of all progression cases (48 %) in the comparison group appeared to be hematogenic metastasis. Most often the lungs and bones damage was detected.
A rare missense Duchenne muscular dystrophy gene variant in a family with muscular dystrophy from Turkey
Authors: TOKGÜN Onur , ALBUZ Burcu , KARAGENÇ Nedim , ERDOĞAN Çağdaş , DEMİRAY Aydın , AKÇA Hakan 
Published: January 2022

Objectives: Duchenne and Becker muscular dystrophies (DMD/BMD) are muscle diseases that show X-linked recessive inheritance. The disease occurs depending on large mutations, deletions/duplications, small mutations, point mutations and mid-intronic mutations of the gene encoding the protein called dystrophin. Therefore, in this study, we aimed to investigate the pathogenic variants of DMD in the affected family. Methods: A 23-year-old male who had weakness in the muscles, difficulty climbing the stairs, frequent falls at the age of seven was referred to the Medical Genetics department for an initial diagnosis of DMD/BMD. His siblings also suffered from similar symptoms. Therefore, eight individuals from the same family were included in the study. MLPA analysis was performed to evaluate deletion/duplication and variants of the DMD gene were evaluated by targeted NGS. Sophia DDM algorithms were used for the bioinformatics analysis of data, and the pathogenicity of the mutations was evaluated based on in silico prediction tools. Results: Allelic variants were identified in 8 individuals of the family including two suspected patients and six suspected obligatory carriers. NGS analysis revealed that proband and his nephew were hemizygous for pathogenic c.10018T&gt; C (p.Cys3340Arg, C3340R) mutation and mother, two sisters and niece were carriers. Conclusions: C3340R mutation was first reported in a Taiwanese BMD patient among the 23 different pathologic changes. This variant identified as pathogenic because of being highly conserved cysteine substitution in the dystroglycan-binding domain of dystrophin. This study has the importance of reporting an infrequent pathogenic mutation, C3340R, in two patients and four suspected obligatory carriers of a Turkish family.
KUMPULAN PUISI PERJAMUAN KHONG GUAN KARYA JOKO PINURBO SEBAGAI BAHAN AJAR BAHASA INDONESIA DI SMA (KAJIAN STILISTIKA)
Authors: Argiandini Septian Refvinda , Suyitno Suyitno , Waluyo Herman J. 
Published: January 2022

<p class="p" align="justify"><span lang="IN">Kompleksnya unsur</span><span> kebahasaan teks</span><span lang="IN"> puisi seperti penggunaan diksi</span><span>, </span><span lang="IN">gaya bahasa, dan citraan membuat guru dan siswa kesulitan memahami puisi. Minimnya bahan ajar sastra juga membuat pembelajaran sastra di sekolah kurang bervariatif</span><span>. </span><span lang="IN">Penelitian ini bertujuan untuk mendeskripsikan dan menjelaskan (1) diksi Kumpulan Puisi <em>Perjamuan Khong Guan</em>, (2) gaya bahasa Kumpulan Puisi <em>Perjamuan Khong Gua</em>, (3) citraan Kumpulan Puisi <em>Perjamuan Khong Guan</em> (4) pemanfaatan diksi, gaya bahasa, citraan dalam pembelajaran bahasa Indonesia tingkat Sekolah Menengah Atas. Jenis penelitian ini adalah penelitian deskriptif kualitatif, menggunakan pendekatan stilistika sastra. Sumber data dalam penelitian adalah dokumen kumpulan puisi <em>Perjamuan Khong Guan</em> Karya Joko Pinurbo. Teknik pengambilan sampel menggunakan metode <em>purposive sampling</em>. Teknik pengumpulan data yang digunakan yaitu dengan cara analisis dokumen dan wawancara. Peneliti menggunakan triangulasi teori dan triangulasi sumber data sebagai uji validitas data. Teknik analisis data yang digunakan dalam penelitian adalah teknik analisis isi. Hasil penelitian ini dapat dikemukakan bahwa (1) diksi paling dominan dari kumpulan puisi <em>Perjamuan Khong Guan </em>Karya Joko Pinurbo adalah diksi konotatif. (2) Gaya bahasa yang paling dominan dari kumpulan puisi tersebut adalah gaya bahasa metafora. (3) Citraan yang paling dominan dari kumpulan puisi tersebut adalah citraan gerak. (4) Kumpulan Puisi <em>Perjamuan Khong Guan</em> dapat dimanfaatkan dalam pembelajaran teks puisi kelas X Sekolah Menengah Atas.</span><span>Kesimpulan dari penelitian ini adalah bahwa hasil </span><span>analisis </span><span lang="IN">diksi, gaya bahasa dan citraan dalam penelitian </span><span>juga </span><span lang="IN">dapat dijadikan sebagai inspirasi untuk menulis puisi dengan nilai esteti</span><span>s</span><span lang="IN"> yang tinggi.</span></p><p align="justify"> </p>
ANALISIS SISTEM APRAISAL PADA ARTIKEL PORTAL BERITA ONLINE LIPUTAN 6 YANG BERJUDUL CLAUDIA SI CANTIK PEMIMPIN KARTEL NARKOBA MIRIP KIM KARDASHIAN
Authors: Nugroho Muhammad Aprianto Budie 
Published: January 2022

<p>This reserach focus on apprasisal system analysis on an article entitled”<em>Claudia si cantik pemimpin kartel narkoba mirip Kim Kadarshian”</em>. In this reserach the researcher uses descriptive qualitative method, the data is taken form the news portal liputan6.com that’s afiliated in Surya Citra Televisi (SCTV). That text is analyzed by using appraisal system that focuse on attitude (affect, judgement, and appreciation) amplifying attitude and source of attitude (graduation). The result of this reserach shows that there are many positive apresiataion on Claudia eventhough Claudia is a drug lord.</p><p> </p><p> </p>
Part One: Abuse Liability of Vuse Solo Relative To Combustible Cigarettes And Nicotine Gum
Authors: Campbell Chris , Jin Tao , Round Elaine K. , Schmidt Eckhardt , Nelson Paul , Baxter Sarah 
Published: January 2022

Abstract
Abuse liability (AL) of electronic nicotine delivery systems (ENDS) is relevant as the category increases in popularity as a potentially less-harmful alternative to cigarette smoking. AL assessments are important to the FDA in determining if a new product is appropriate for the protection of public health. This paper reports the results for Vuse Solo and high and low AL-comparators evaluated in an open-label, randomized crossover confinement AL study. The confinement design was adapted from previous ambulatory studies of Vuse Solo and included product familiarization sessions before each four-hour test session in which subjective measures, nicotine uptake, and physiological endpoints were assessed following a single 10-minute ad libitum product use session. Product liking, intent to use again, suppression of urge to smoke, and nicotine uptake were lower after use of Vuse Solo compared to cigarettes and higher after use of Vuse Solo compared to nicotine gum. No significant differences in blood pressure or heart rate were observed between the products pre- to post-product use. These data reinforce previous research showing that Vuse Solo has an AL profile lower than that of combustible cigarettes but higher than that of nicotine gum and may have sufficient AL for product adoption by current adult smokers.
Time-Resolved Thickness and Shape-Change Quantification using a Dual-Band Nanoplasmonic Ruler with Sub-Nanometer Resolution
Authors: Nugroho Ferry , Switlik Dominika , Armanious Antonius , O'Reilly Padraic , Darmadi Iwan , Nilsson Sara , Zhdanov Vladimir , Höök Fredrik , Antosiewicz Tomasz , Langhammer Christoph 
Published: January 2022

Abstract
Time-resolved measurements of changes in size and shape of nanobiological objects and layers are crucial to understand their properties and optimize their performance. Optical sensing is particularly attractive with high throughput and sensitivity, and label-free operation. However, most state-of-the-art solutions require intricate modelling or multiparameter measurements to disentangle conformational or thickness changes of biomolecular layers from complex interfacial refractive index variations. Here, we present a dual-band nanoplasmonic ruler comprising mixed arrays of plasmonic nanoparticles with spectrally separated resonance peaks. As electrodynamic simulations and model experiments show, it enables real-time simultaneous measurements of thickness and refractive index variations in uniform and heterogeneous layers with sub-nanometer resolution. Additionally, nanostructure shape changes can be tracked, as demonstrated by quantifying the degree of lipid vesicle deformation at the critical coverage prior to rupture and supported lipid bilayer formation. In a broader context, the presented nanofabrication approach opens the door to multimodal nanoplasmonic optical sensing.
Effects of Underwater Ship Sound and Urban Noise on Voluntary Feeding and Growth Response of Fish
Authors: Kusku Halit 
Published: January 2022

Abstract
The drastically increase of human population and urbanization in waterfronts has boosted the shipping industry along the coast line of urbanized areas. In the present study, impacts of rising noise pollution in coastal areas due to intense urbanization at waterfronts and ship sound from harbors on possible acclimation response of fish through the assessment of voluntary feeding and growth performance have been evaluated. During the initial 15-days of sound exposure, fish growth was almost stable with a linear growth trend. However, an increasing trend was noted from day-30 onwards over the following 60 days until the end of the study (day-90), which could be linked to a time-dependent acclimation of fish to ship sound and urban noise. A remarkable shift towards a significant increase in growth after the first 15-days of slow-growth trend in fish exposed to underwater sound transmissions presented evidence for a “catch-up growth endeavor”, that resulted in an increased voluntary feeding, indicating that nearshore populations of fish near harbors, ferry ports and noisy intense urban waterfronts might acclimate to noisy conditions over a certain time, which was found as 15-30 days under the conditions applied in this study. These findings may support policymakers for environmental management towards an ecology-based planning of near-shore industrial development.
Comparison of End-To-End Descending Hypoglossal-Facial Anastomosis And End-To-Side Hypoglossal-Facial Anastomosis For Facial Paralysis After Vestibular Schwannoma Surgery
Authors: Song Gang , Zhou Yiqiang , Wu Yafang , Wu Xiaolong , Li Mingchu , Guo Hongchuan , Chen Ge , Bao Yuhai , Liang Jiantao 
Published: January 2022

Abstract
Background: We aimed to compare the outcomes of end-to-end descending hypoglossal-facial anastomosis (eeDHFA) and end-to-side hypoglossal-facial anastomosis (esHFA) in patients with complete facial paralysis after vestibular schwannoma (VS) surgery. Methods: This retrospective study included 52 patients with complete nerve damage identified during previous VS removal or on electromyography during follow-up. Postoperative facial palsy was evaluated using the House-Brackmann (HB) facial nerve grading system. Postoperative hemiglossal atrophy and swallowing were assessed using Martins’ grading system and the water-swallowing test, respectively. Hoarseness was also recorded if present. Results: The median time from VS resection to anastomosis was not significantly different between the two groups (p=0.062). The median follow-up time showed no significant differences between groups (eeDHFA: 17 months; esHFA: 14 months; p=0.446). We found no significant differences in the number of favourable (HB I-III) or unfavourable (HB IV-VI) outcomes for facial nerve function in the last follow-up (p=0.924). Only one patient from each group developed hemi-tongue myoparalysis. No patient experienced swallowing dysfunction or hoarseness. Conclusions: We concluded that eeDHFA is as effective as esHFA as a surgical method for the treatment of facial palsy after VS surgery. Since eeDHFA represents a simple technique for facial reanimation, it could therefore be considered as an alternative surgical option for patients affected by complete facial paralysis after VS surgery.
Effects of the COVID-19 outbreak on the use and perceptions of metropolitan agricultural parks. Evidence from Milan and Naples
Authors: Cattivelli Valentina , Rusciano Vincenzo , Gatto Andrea 
Published: January 2022

Abstract
This article describes the multi-function of the metropolitan agricultural parks in Milan (Parco Agricolo Sud Milano) and Naples (Parco De Filippo), as well as their resilience within the last period of the lockdown enforced for limiting the COVID-19 diffusion in Italy. These parks play an important role in the urban regeneration and social inclusion processes in their relative metropolitan areas. Nevertheless, the restrictions imposed to limit COVID-19 contagions have imposed their closure or severely limited their activities, with evident consequences on the local population wellbeing. Exploiting a document analysis and the elaboration of a semi-structured interview with the directors, the article lists the multiple functions of the parks and underlines their multidimensional governance vocations for fostering sustainable development (environmental, economic and social functions). The study also reveals that, during the lockdown, the parks’ activities have been strongly reduced or restructured. Recreational and educational activities were lifted in Parco Agricolo Sud in Milan, whilst local farms restructured their food supply, fostered their network and linkages with the urban distribution channels. In the same period, the metropolitan park analyzed in Naples had to stop its activities and reorganize into smart-working, holding meetings with its users throughout dedicated apps. Lastly, the article reveals that economic activities were resumed with greater urgency in Milan, whereas in Naples the recovery of the social ones has taken on greater importance. Farms network continued to operate in Milan Metropolitan Parks. Despite the limited number of offered social initiatives here, the local population was attracted. Right after the post-lockdown phase, the De Filippo urban park has, indeed, resumed all social activities: care of community gardens, public events, school visits.JEL codes: O13; O18; Q01; Q23.
Thermal Behavior of an Improved Face-Grinding Spindle: Water-Lubricated Hydrostatic Thrust Bearing Decreases Temperature Rise and Increases Axial Stiffness
Authors: Jiang Shuyun , Lin Shengye , Liu Fukang 
Published: January 2022

Abstract
Axial thermal deformation and axial stiffness are main technical indicators to affect manufacturing accuracy of face-grinding spindle. However, the face-grinding spindle supported by rolling bearings lubricated with grease has a relative disadvantage in respect of temperature rise, axial stiffness and rotational accuracy. To overcome this issue, this study proposes a novel face-grinding spindle supported by a combined bearings, which include a water-lubricated hydrostatic thrust bearing and two rolling bearings with oil-air lubrication system. The thermal model for the proposed face-grinding spindle is established and the spindle thermal behavior is analyzed systematically. An experiment prototype of the face-grinding spindle is developed, and temperature rise of the spindle is detected to verify the thermal model. The result shows that the temperature rise of the proposed spindle can be decreased by the using of the water-lubricated hydrostatic thrust bearing. A comparative study between the two types of spindles shows that the proposed face-grinding spindle with the combined support has technical advantage of low temperature rise, large axial stiffness and low rotation accuracy, etc.
Implementation of the Right to Healthy Environment: Regulations for running air conditioners in public buildings and recognition of biological pollutants.
Authors: Singh Raja , Dewan Anil 
Published: January 2022

Abstract
The Indian Supreme Court has declared the right to healthy environment a fundamental right available to citizens of India. This in contrast to Indian executive’s abstention from voting on the resolution for the right to healthy environment at United Nations Human Rights Council. Indian citizens may now be forced move courts for basic rights like clean and healthy air instead of a stronger executive action. This study uses an example of nine public buildings in New Delhi to show that air conditioners have an impact on the indoor air quality of congregational. This impact is all the more severe as it has a relation to the spread of airborne infections like COVID-19. The study highlights the paradox of fresh air intake for infection control and how it brings in polluted air due to ill equipped air conditioning systems. It also highlights biological contaminants’ non recognition as pollutants. The data was gathered by the use of the Right to Information Act, 2005 and was studied to reinforce the evidence-based lack of regulations and implementation in New Delhi. The focus today must be on making regulations so that people in India realise their right to breathable air and a healthy environment.
Expression of Inflammatory Markers In The Muscles of Patients With Idiopathic Inflammatory Myopathy According To The Presence of Interstitial Lung Disease
Authors: Lee Jung Sun , Ghang Byeongzu , Choi Wonho , Hong Seokchan , Kim Yong-Gil , Lee Chang-Keun , Nam Soo Jeong , Yoo Bin 
Published: January 2022

Abstract

Objective. Several studies have identified factors associated with the development of interstitial lung disease (ILD) in patients with idiopathic inflammatory myopathies (IIMs). However, few have assessed the association between ILD and muscle biopsy findings including inflammatory marker expressions analyzed using immunohistochemistry (IHC). We investigated the muscle biopsy findings that were associated with the presence of ILD.Methods. Muscle biopsies from patients who were newly diagnosed with IIMs between 2000 and 2017 were reviewed. ILD was diagnosed based on high-resolution computed tomography findings at the time of diagnosis of IIMs. IHC staining was performed for CD3, CD4, CD8, CD20, CD68, CD163, MX1, MHC class I, and HLA-DR. The factors associated with the presence of ILD were evaluated by logistic regression analysis. Results. Of the 129 patients with IIM, 49 (38%) had ILD. In muscle biopsy findings, CD4 expression (47% vs. 29%, P = 0.036), MX1 expression on immune cell (29% vs. 13%, P = 0.023), and expression of MHC class I (67% vs. 41%, P = 0.004) and HLA-DR (37% vs. 11%, P = 0.001) on myofiber were more common in patients with ILD than those without. In logistic regression analysis, HLA-DR expression on myofiber was significantly associated with the risk of ILD (OR, 2.39; 95% CI, 1.24–4.90, P = 0.012) after adjusting for pathologic findings, clinical features, and autoantibodies.Conclusion. Expression of HLA-DR on myofibers was associated with the presence of ILD in patients with IIM.