bluuebunny/crossref_metadata_2025_split huggingface dataset:
O impacto do isolamento social da COVID-19 na auto percepção da saúde geral e emocional de brasileiros
Authors: Oliveira Priscila Feliciano de , Jesus Amanda Souza de , Oliveira Anderson Barbosa Sá , Santos Swyanne Vitória Rodrigues dos , Silva Aparecida Grasiele de Lima , Oliveira Gabriele Sousa de , Raposo Oscar Felipe Falcão , Guedes-Granzoti Raphaela Barroso 
Published: January 2022

A fim de proteger a população da COVID-19 e conter a disseminação do vírus foi proposto o isolamento social. Porém, o confinamento e as medidas restritivas de circulação geraram impactos negativos na população, no que diz respeito principalmente à saúde e ao aspecto emocional. Objetivo: Analisar o impacto do isolamento social da COVID-19 na autopercepção da saúde geral e emocional de brasileiros. Metodologia: Fizeram parte deste estudo 660 participantes, sendo a coleta realizada de agosto a setembro de 2020 durante a pandemia da Covid -19. Foi aplicado um questionário por meio eletrônico idealizado pelos pesquisadores com 26 perguntas fechadas de múltipla escolha (dados de identificação, saúde em geral e aspectos emocionais). Resultados: Média de idade de 36 anos, sendo 80% do gênero feminino, residentes de todos os estados brasileiros. 36,2% trabalharam em home office e 17,4% perderam o emprego durante a pandemia. 50,7% cumpriram o isolamento social à risca. Dentre os aspectos emocionais a ansiedade (p=0,083) e estresse (p=0,014) foram as mais destacadas, além de existir mudança significativa na alimentação (p=0,017) e presença de zumbido (p=0,070). Dos sujeitos positivos para COVID-19 (n=73) os dados foram significativos para estresse (p=0,017), presença de zumbido (p=0,038) e tontura (p=0,000). Conclusão: Concluiu-se que o isolamento social foi um fator de risco para aumento do estresse, mudança de hábitos alimentares e aparecimento de zumbido, além de uma tendencia maior para ansiedade; e que a infecção por COVID-19 foi um fator de risco para o estresse e para o surgimento de tontura e zumbido entre os participantes.
Qualidade físico-química, microbiológica e identificação de compostos voláteis em amostras comerciais de queijo parmesão ralado
Authors: Andrade Vinícius Moura , Machado Ana Maria de Resende , Gomes Fátima de Cássia Oliveira 
Published: January 2022

O queijo parmesão é consumido pela população na forma ralada, o que tem proporcionado uma maior opção de marcas do produto no mercado. No entanto, o queijo é um produto susceptível a contaminações, oferecendo riscos à Saúde Pública. Poucos estudos sobre esse assunto têm sido publicados na literatura, tornando-se importante averiguar a qualidade dos produtos disponíveis no mercado. Assim, o trabalho teve por objetivo avaliar a qualidade microbiológica, determinar o teor de umidade e o perfil de compostos voláteis de diferentes amostras embaladas e a granel de queijo parmesão ralado, disponíveis no comércio, verificando se os produtos atendem aos padrões estabelecidos pela legislação. Em relação a umidade, observou-se que 50% das amostras apresentaram valores acima do permitido (20 g/100 g). Nas análises microbiológicas verificou-se que 70% das amostras estavam impróprias para o consumo com contagens acima do permitido pela legislação para bolores e leveduras, Staphylococcus spp. e coliformes totais. Em algumas amostras foram identificadas a presença de coliformes termotolerantes e Escherichia coli, mas não ultrapassaram o padrão estabelecido pela legislação. A análise dos compostos voláteis permitiu a identificação de 31 compostos de diferentes classes como cetonas (7), ésteres (7), ácidos carboxílicos (6), aldeídos (4), álcoois (2), lactonas (2), hidrocarboneto aromático (1), terpeno (1) e triacetina (1). Observou-se variação na composição química entre os queijos embalados e a granel. Essas variações podem ser observadas na falta de uniformidade das amostras o que requer a necessidade de uma fiscalização mais eficiente pelos órgãos oficiais e melhorias nas condições higiênicas durante a fabricação.
KADIE LAPANDEWA SEBAGAI MATANA SORUMBA KESULTANAN BUTON PADA MASA PEMERINTAHAN SULTAN DAYANU IKHSANUDDIN: 1610-1631
Authors: Halimuna Halimuna , Ali Basri La Ode , Hayari Hayari 
Published: January 2022

Tujuan penelitian ini adalah untuk mengetahui penyebab Kadie Lapandewa dijadikan sebagai Matana Sorumba Kesultanan Buton, untuk mengetahui kedudukan Kadie Lapandewa dalam struktur pemerintahan Kesultanan Buton, dan untuk mengetahui fungsi Kadie Lapandewa sebagai Matana Sorumba Kesultanan Buton bagian Selatan. Metode penelitian yang digunakan adalah metode penelitian sejarah menurut Kuntowijoyo yang terdiri dari lima tahap yaitu: (1) Pemilihan topik; (2) Heuristik sumber; (3) Verifikasi sumber; (4) Interpretasi sumber; serta (5) Historiografi. Hasil penelitian ini menunjukkan bahwa: (1) Kadie Lapandewa dijadikan sebagai Matana Sorumba Kesultanan Buton karena Lapandewa sebelumnya merupakan bagian dari pertahanan dan keamanan Kerajaan Tobe-Tobe sehingga sebagai Matana Sorumba yang salah satu tugas utamanya adalah untuk menjaga keamanan wilayah tertentu, dalam hal ini keamanan wilayah Lapandewa, diharapkan dapat terlaksana dengan baik; (2) Kesultanan Buton dalam strukturnya terdiri atas dua bagian besar yaitu Wilayah Barat (Sukanaeo) yang dipimpin oleh Bontona Peropa dan Wilayah Timur (Matanaeo) yang dipimpin oleh Bontona Baluwu. Lapandewa termasuk dalam wilayah Matanaeo. Kadie Lapandewa dalam struktur pemerintahan Kesultanan Buton termasuk dalam pembinaan Bontona Baluwu yang merupakan salah satu anggota Siolimbona; (3) Fungsi Kadie Lapandewa sebagai Matana Sorumba Kesultanan Buton bagian Selatan dapat terlihat dalam fungsi politik, fungsi ekonomi, fungsi sosial, dan fungsi pertahanan.
DISTRIK RUMBIA PADA MASA PEMERINTAHAN MOKOLE I PIMPIE: 1950-1962
Authors: Karmianti Karmianti , Suddin Suharni , Malik Elmy Selfiana 
Published: January 2022

Penelitian ini bertujuan untuk mengetahui profil Mokole I Pimpie dan untuk mengetahui perkembangan Distrik Rumbia pada masa Pemerintahan Mokole I Pimpie 1950-1962. Metode yang digunakan dalam penelitian ini adalah metode sejarah dengan tahapan sebagai berikut: (1) pemilihan topik; (2) heuristik sumber; (3) verifikasi sumber; (4) interprestasi sumber, serta (5) historiografi. Hasil penelitian menunjukan bahwa Mokole I Pimpie merupakan putra dari Mokole Munara. Mokole I Pimpie menggantikan Mokole Munara menjadi Kepala Distrik dengan gelar Mokole Keuwia-Rumbia ke-V pada tahun 1950. Pada masa pemerintahan Mokole I Pimpie, Distrik Rumbia mendapat gangguan keamanan dari gerombolan badik dan juga gangguan dari kelompok DI/TII. Distrik Rumbia di bawah pimpinan Mokole I Pimpie pada mulanya merupakan wilayah yang makmur, namun setelah masuknya gerombolan DI/TII di Rumbia pada sekitar tahun 1953 wilayah Rumbia menjadi terpuruk. Kondisi keamanan Distrik Rumbia yang tidak kondusif dengan adanya gerombolan DI/TII memengaruhi berbagai bidang kehidupan masyarakat Rumbia, baik dalam bidang ekonomi, sosial budaya, serta politik. Mokole I Pimpie mulai memulihkan kembali kondisi Distrik Rumbia setelah gerombolan DI/TII berhasil ditumpas pada tahun 1959 hingga berakhirnya sistem kedistrikan pada tahun 1962.
TANTANGAN ADMINISTRASI PENGENAAN PAJAK KARBON DI INDONESIA
Authors: Sutartib Muh. 
Published: January 2022

Pengenaan pungutan atas karbon baik dalam bentuk pajak atau cukai menjadi semakin umum dilakukan di berbagai negara sehubungan dengan kekhawatiran terjadinya perubahan iklim akibat bertambahnya emisi karbondioksida (CO2) yang berimplikasi dengan efek gas rumah kaca. Di Indonesia pungutan atas karbon menjadi semakin mendesak setelah meratifikasi Persetujuan Paris. Penelitian bertujuan menganalisis tantangan yang akan dihadapi oleh pemungut pajak (fiskus) terutama tantangan administrasi jika pengenaan pajak karbon disetujui oleh Dewan Perwakilan Rakyat. Metode penelitian yang digunakan adalah metode kualitatif, dengan reseacrh design berupa case study menggunakan data sekunder yang dikumpulkan sampai dengan September 2021. Penelitian menghasilkan pilihan dalam mendesain pajak karbon bisa dilakukan dengan Pendekatan Bahan Bakar, Pendekatan Emisi Langsung atau gabungan dari dua pendekatan ini. Indonesia sebaiknya mengenakan pajak karbon untuk sektor transportasi, rumah tangga, industri kecil maupun kegiatan sejenis menggunakan Pendekatan Bahan Bakar sedangkan untuk pembangkit tenaga listrik, industri-industri besar serta kegiatan lainnya yang emisi GRK besar dan tidak hanya berasal dari penggunaan bahan bakar fosil sebaiknya memakai Pendekatan Emisi Langsung. Pembuatan payung hukum yang menugaskan institusi (K/L) lain untuk membantu fiskus dalam mendesain pajak karbon terutama untuk aktivitas yang menimbulkan jejak karbon (Pendekatan Emisi Langsung) mutlak diperlukan agar diperoleh desain pajak karbon yang tepat serta mudah diimplementasikan.
Kata kunci: emisi karbondioksida, gas rumah kaca, pungutan karbon, persetujuan paris
Ultrasound-Guided Percutaneous Thermal Ablation of Hepatic Focal Nodular Hyperplasia——A Multicenter Retrospective Study
Authors: Yu Xuan , Chang Jiandong , Zhang Dezhi , Lu Qiang , Wu Songsong , Li Kai 
Published: January 2022

Background and Aim: To evaluate the clinical effect of ultrasound (US)-guided percutaneous thermal ablation of hepatic focal nodular hyperplasia (FNH).Methods: A retrospective analysis of the clinical data of patients undergoing US-guided percutaneous thermal ablation of FNH from November 2008 to August 2021 at five medical centers in China was conducted.Results: A total of 53 patients were included (26 males and 27 females). The mean age was 35.1 ± 10.8 years. Sixty-five lesions (46 solitary cases and 7 cases with multiple lesions) were included, 70.8% (46/65) of which were located in the right liver lobe. The mean tumor length was 2.9 ± 1.5 cm. All patients successfully completed the ablation treatment. Immediate postoperative imaging showed that the primary technical success rate was 94.3% (50/53). Two patients underwent ablation 3 and 6 months after the primary ablation, and the secondary technical success rate was 100% (2/2). The incidence of complications was 3.8% (2/53). Imaging follow-up was conducted regularly after ablation, and no residual lesion enlargement or tumor recurrence was observed during the follow-up period. The technique efficacy rate was 98.1% (52/53).Conclusion: US-guided percutaneous thermal ablation is a safe and effective treatment for FNH of the liver.
Filarial Lymphedema Patients Are Characterized by Exhausted CD4+ T Cells
Authors: Horn Sacha , Ritter Manuel , Arndts Kathrin , Borrero-Wolff Dennis , Wiszniewsky Anna , Debrah Linda Batsa , Debrah Alexander Y. , Osei-Mensah Jubin , Chachage Mkunde , Hoerauf Achim , Kroidl Inge , Layland Laura E. 
Published: January 2022

Worldwide, more than 200 million people are infected with filariae which can cause severe symptoms leading to reduced quality of life and contribute to disability-adjusted life years (DALYs). In particular, lymphatic filariasis (LF) caused by Wuchereria bancrofti can lead to lymphedema (LE) and consequently presents a serious health problem. To understand why only a fraction of the infected individuals develop pathology, it is essential to understand how filariae regulate host immunity. The central role of T cells for immunity against filariae has been shown in several studies. However, there is little knowledge about T cell exhaustion, which causes T cell dysfunction and impaired immune responses, in this group of individuals. Recently, we showed that LE patients from Ghana harbor distinct patterns of exhausted effector and memory CD8+ T cell subsets. Based on these findings, we now characterized CD4+ T cell subsets from the same Ghanaian patient cohort by analyzing distinct markers within a 13-colour flow cytometry panel. We revealed that LE patients had increased frequencies of CD4+ T cells expressing exhaustion-associated receptors such as KLRG-1, TIM-3 and PD-1 compared to healthy endemic normal and W. bancrofti-infected individuals. Moreover, CD4+ T cells in LE patients were characterized by distinct co-expression patterns of inhibitory receptors. Collectively with the previous findings on CD8+ T cell exhaustion patterns, the data shown here demonstrates that filarial LE patients harbor distinct subsets of exhausted T cells. Thus, T cell exhaustion patterns in LE patients need attention especially in regards to susceptibility of concomitant infections and should be taken into consideration for LE management measures.
Association Between Preoperative Monocyte to High-Density Lipoprotein Ratio on In-hospital and Long-Term Mortality in Patients Undergoing Endovascular Repair for Acute Type B Aortic Dissection
Authors: Xie Enmin , Yang Fan , Luo Songyuan , Liu Yuan , Xue Ling , Huang Wenhui , Xie Nianjin , Chen Lyufan , Liu Jitao , Yang Xinyue , Su Sheng , Li Jie , Luo Jianfang 
Published: January 2022

Aims: The monocyte to high-density lipoprotein ratio (MHR), a novel marker of inflammation and cardiovascular events, has recently been found to facilitate the diagnosis of acute aortic dissection. This study aimed to assess the association of preoperative MHR with in-hospital and long-term mortality after thoracic endovascular aortic repair (TEVAR) for acute type B aortic dissection (TBAD).Methods: We retrospectively evaluated 637 patients with acute TBAD who underwent TEVAR from a prospectively maintained database. Multivariable logistic and cox regression analyses were conducted to assess the relationship between preoperative MHR and in-hospital as well as long-term mortality. For clinical use, MHR was modeled as a continuous variable and a categorical variable with the optimal cutoff evaluated by receiver operator characteristic curve for long-term mortality. Propensity score matching was used to diminish baseline differences and subgroups analyses were conducted to assess the robustness of the results.Results: Twenty-one (3.3%) patients died during hospitalization and 52 deaths (8.4%) were documented after a median follow-up of 48.1 months. The optimal cutoff value was 1.13 selected according to the receiver operator characteristic curve (sensitivity 78.8%; specificity 58.9%). Multivariate analyses showed that MHR was independently associated with either in-hospital death [odds ratio (OR) 2.11, 95% confidence interval (CI) 1.16-3.85, P = 0.015] or long-term mortality [hazard ratio (HR) 1.78, 95% CI 1.31-2.41, P &lt; 0.001). As a categorical variable, MHR &gt; 1.13 remained an independent predictor of in-hospital death (OR 4.53, 95% CI 1.44-14.30, P = 0.010) and long-term mortality (HR 4.16, 95% CI 2.13-8.10, P &lt; 0.001). Propensity score analyses demonstrated similar results for both in-hospital death and long-term mortality. The association was further confirmed by subgroup analyses.Conclusions: MHR might be useful for identifying patients at high risk of in-hospital and long-term mortality, which could be integrated into risk stratification strategies for acute TBAD patients undergoing TEVAR.
Can Cardiopulmonary Rehabilitation Facilitate Weaning of Extracorporeal Membrane Oxygenation (CaRe-ECMO)? Study Protocol for a Prospective Multidisciplinary Randomized Controlled Trial
Authors: Zheng Yu , Sun Hao , Mei Yong , Gao Yongxia , Lv Jinru , Pan Dijia , Wang Lu , Zhang Xintong , Hu Deliang , Sun Feng , Li Wei , Zhang Gang , Zhang Huazhong , Chen Ying , Wang Shenrui , Zhang Zhongman , Li Baoquan , Chen Xufeng , Zhang Jinsong , Lu Xiao 
Published: January 2022

Background: Mortality of patients suffering from critical illness has been dramatically improved with advanced technological development of extracorporeal membrane oxygenation (ECMO) therapy. However, the majority of ECMO-supported patients failed to wean from ECMO therapy. As one of several options, cardiopulmonary rehabilitation serves as effective intervention in the improvement of cardiovascular and respiratory function in various major critical illness. Nonetheless, its role in facilitating ECMO weaning has not yet been explored. The purpose of this study is to investigate the effectiveness of cardiopulmonary rehabilitation on rate of ready for ECMO weaning in ECMO-supported patients (CaRe-ECMO).Methods: The CaRe-ECMO trial is a randomized controlled, parallel group, clinical trial. This trial will be performed in a minimum number of 366 ECMO-supported eligible patients. Patients will be randomly assigned to either: (1) the CaRe-ECMO group, which will be treated with usual care including pharmacotherapy, non-pharmacotherapy, and specific nursing for ECMO therapy and the CaRe-ECMO program; or (2) the control group, which will receive usual care only. The CaRe-ECMO program consists of protocolized positioning, passive range of motion (PROM) training, neuromuscular electrical stimulation (NMES), surface electrical phrenic nerve stimulation (SEPNS), and pulmonary rehabilitation. The primary outcome of the CaRe-ECMO trial is the rate of ready for ECMO weaning at CaRe-ECMO day 7 (refers to 7 days after the CaRe-ECMO program initiation). Secondary outcomes include rate of ECMO and mechanical ventilation weaning, total length in day of ready for ECMO weaning, ECMO weaning and mechanical ventilation, all-cause mortality, rate of major post-ECMO complications, ECMO unit length of stay (LOS) and hospital LOS, total cost for hospitalization, cerebral performance category (CPC), activities of daily living (ADL), and health-related quality of life (HRQoL).Discussion: The CaRe-ECMO is designed to answer the question “whether cardiopulmonary rehabilitation can facilitate weaning of ECMO (CaRe-ECMO).” Should the implementation of the CaRe-ECMO program result in superior primary and secondary outcomes as compared to the controls, specifically the add-on effects of cardiopulmonary rehabilitation to the routine ECMO practice for facilitating successful weaning, the CaRe-ECMO trial will offer an innovative treatment option for ECMO-supported patients and meaningfully impact on the standard care in ECMO therapy.Clinical Trial Registration:ClinicalTrials.gov, identifier: NCT05035797.
SNP and Haplotype Regional Heritability Mapping (SNHap-RHM): Joint Mapping of Common and Rare Variation Affecting Complex Traits
Authors: Oppong Richard F. , Boutin Thibaud , Campbell Archie , McIntosh Andrew M. , Porteous David , Hayward Caroline , Haley Chris S. , Navarro Pau , Knott Sara 
Published: January 2022

We describe a genome-wide analytical approach, SNP and Haplotype Regional Heritability Mapping (SNHap-RHM), that provides regional estimates of the heritability across locally defined regions in the genome. This approach utilises relationship matrices that are based on sharing of SNP and haplotype alleles at local haplotype blocks delimited by recombination boundaries in the genome. We implemented the approach on simulated data and show that the haplotype-based regional GRMs capture variation that is complementary to that captured by SNP-based regional GRMs, and thus justifying the fitting of the two GRMs jointly in a single analysis (SNHap-RHM). SNHap-RHM captures regions in the genome contributing to the phenotypic variation that existing genome-wide analysis methods may fail to capture. We further demonstrate that there are real benefits to be gained from this approach by applying it to real data from about 20,000 individuals from the Generation Scotland: Scottish Family Health Study. We analysed height and major depressive disorder (MDD). We identified seven genomic regions that are genome-wide significant for height, and three regions significant at a suggestive threshold (p-value &lt; 1 × 10−5) for MDD. These significant regions have genes mapped to within 400 kb of them. The genes mapped for height have been reported to be associated with height in humans. Similarly, those mapped for MDD have been reported to be associated with major depressive disorder and other psychiatry phenotypes. The results show that SNHap-RHM presents an exciting new opportunity to analyse complex traits by allowing the joint mapping of novel genomic regions tagged by either SNPs or haplotypes, potentially leading to the recovery of some of the “missing” heritability.
Acute Vertigo After COVID-19 Vaccination: Case Series and Literature Review
Authors: Di Mauro Paola , La Mantia Ignazio , Cocuzza Salvatore , Sciancalepore Pasqua Irene , Rasà Deborak , Maniaci Antonino , Ferlito Salvatore , Tundo Isabella , Anzivino Roberta 
Published: January 2022

Objective: The aim of this study was to present some cases of acute vertigo potentially related to the coronavirus disease 2019 (COVID-19) vaccine and review the available literature about cochleovestibular dysfunction after the COVID-19 vaccination.Methods: In the period from May to July 2021, we evaluated 33 patients (mean age 54.3 ± 14.1) with “acute vertigo” post COVID-19 vaccination. A detailed medical history was taken on comorbidities, types of vaccines received, and symptoms associated. All patients underwent otoneurological evaluation, such as head impulse test, nystagmus evaluation, test of skew (HINTS) examination. Head shaking test-induced nystagmus, hyperventilation-induced nystagmus, and parossistic positional nystagmus were studied to search for vestibular impairment.Results: Symptoms included 16 patients (48.5%) with objective vertigo, 14 patients (42.4%) with subjective vertigo, and 3 patients (9.1%) with dizziness. Of the associated ear, nose, and throat (ENT) symptoms, the most expressed was tinnitus (18.2%). Bedside examination showed absent nystagmus in 7 patients (21.2%), 9 patients (27.3%) had horizontal or rotatory nystagmus, 17 patients (51.5%) had a vertical or oblique nystagmus, negative HST, or “central HINTS.”Discussion and Conclusions: The 9 patients had an evoked nystagmus pathognomonic for benign paroxysmal positional vertigo; in the remaining 17 cases, peripheral vestibular dysfunction could be excluded and central disorder may be suggested. Due to the prevalence of nystagmus of non-peripheral origin, a central nervous system involvement could not be excluded. However, due to the small sample size, a definite cause–effect relationship between vaccination and vertigo cannot be inferred. In light of expected third dose, large-scale and well-designed studies are needed to better define possible adverse reactions of the COVID-19 vaccine.
Diabetes Treatment Is Associated With Better Cognitive Function: The Age Disparity
Authors: Wu Keyi , Liu Huamin , Zheng Jiazhen , Zou Lianwu , Gu Shanyuan , Zhou Rui , Yuan Zelin , Huang Zhiwei , Wu Xianbo 
Published: January 2022

Background: Diabetes mellitus (DM) is a recognised risk factor for cognitive dysfunction. The purpose of this study was to explore the relationship between active treatment for DM and cognitive function in middle-aged (&lt; 60 years) and older adults (≥60 years), respectively.Methods: A total of 13,691 participants (58.55 ± 9.64 years, 47.40% of men) from the Chinese Health and Retirement Longitudinal Study (CHARLS) were included. The participants were classified into three groups according to whether or not they have diabetes and to their diabetes treatment status: diabetes-free, treated-diabetes and untreated-diabetes, in which the diabetes-free group was regarded as reference specially. Cognitive function was assessed by two interview-based measurements for mental intactness and episodic memory.Results: Compared with the participants in the diabetes-free group, the older participants in the treated-diabetes group had better performance in terms of mental intactness (β = 0.37, 95% CI = 0.04–0.70). No significant association was observed in the middle-aged participants. In the subgroup analyses, the lower cognitive score was only observed in people without depression, who had never smoked and drunk, and with a normal weight (body mass index: 18.5–23.9 kg/m2).Conclusion: The cognitive function of actively treated diabetic patients was better than that of patients without diabetes, but the improvement was significant only in elderly people. Depression, smoking, drinking, and an abnormal weight may attenuate this effect.