bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential mRNA Expression and Circular RNA-Based Competitive Endogenous RNA Networks in the Three Stages of Heart Failure in Transverse Aortic Constriction Mice
Authors: Li Xiang , Tan Weijiang , Zheng Shuang , Pyle W. Glen , Zhu Caiyi , Chen Honghua , Kang Le , Wu Jian , Zou Yunzeng , Backx Peter H. , Yang Feng Hua 
Published: March 2022

BackgroundThe murine transverse aortic constriction (TAC) model is frequently used to investigate molecular mechanisms underlying heart failure. However, limited data is available regarding the expression of mRNAs and circRNAs in murine heart failure progression induced by pressure overload.MethodsTransverse aortic constriction was used to induce pressure overload for 2, 4, and 8 weeks in mice. Echocardiographic measurements in B-mode and M-mode, as well as blood flow Doppler data were collected in mice without (sham) and with (2W-, 4W-, and 8W-post-TAC) pressure load. Hearts were excised and morphology, cardiomyocyte size, and fibrosis were determined. RNA sequencing, circRNA microarray, functional mRNA enrichment analysis, hub gene identification, target miRNA interaction, and competitive endogenous RNA (ceRNA) network construction were conducted.ResultsHeart weight, cardiomyocyte hypertrophy, and fibrosis gradually increased over time in the hearts with pressure overload. The 2W-post-TAC hearts displayed concentric hypertrophy, thickened left ventricular walls, and increased EF and FS. The 4W-post-TAC hearts were characterized by preserved EF and FS, dilated atria, and increased left ventricle (LV) systolic volume. The 8W-post-TAC hearts presented with ventricular and atrial dilation, increased LV systolic and diastolic volume, reduced EF and FS, and increased ejection time (MV ET). mRNA expression analysis suggested that cardiac remodeling, immune response dysregulation, and metabolic disorder were the key cellular events in heart failure progression. Depression in chemotaxis and mitochondrial function were predicted in 4W- and 8W-post-TAC myocardia, respectively. A ceRNA network analysis demonstrated that the circRNAs targeted the expression of genes enriched in metabolism dysregulation in the 2W-post-TAC hypertrophic hearts, while they targeted genes enriched in cardiac remodeling in the 4W-post-TAC EF-preserved hearts and in the suppression of oxidative phosphorylation and cardiac contraction in the 8W-post-TAC EF-reduced hearts.ConclusionOur work empirically demonstrates that distinctive features of heart failure, including ventricular hypertrophy, heart failure with preserved EF (HFpEF), and heart failure with reduced EF (HFrEF) are present in the murine pressure overload models. The three stages of heart failure vary in terms of mRNA and circRNA expression, as well as ceRNA regulation in a manner consistent with their structural, functional, and pathological differences.
Self-Compassion and Its Association With Ruminative Tendencies and Vagally Mediated Heart Rate Variability in Recurrent Major Depression
Authors: Svendsen Julie Lillebostad , Schanche Elisabeth , Vøllestad Jon , Visted Endre , Jentschke Sebastian , Karl Anke , Binder Per-Einar , Osnes Berge , Sørensen Lin 
Published: March 2022

BackgroundRecurrent Major Depressive Disorder (MDD) is one of the most disabling mental disorders in modern society. Prior research has shown that self-compassion protects against ruminative tendencies, a key feature of recurrent MDD. In addition, self-compassion has been found to be positively related to higher psychophysiological flexibility (indexed by a higher vagally mediated heart rate variability; vmHRV) in young, healthy adults. To our knowledge, there is a lack of studies on how self-compassion relates to vmHRV in patients with recurrent MDD. The aim of the current study was to investigate whether higher self-compassion would associate with (1) lower ruminative tendencies and (2) higher vmHRV in a sample of adults with recurrent MDD.MethodsWe included a sample of 63 patients (46 females) between 20 and 71 years old (M = 40.24, SD = 12.8) with a history of three or more depressive episodes. They filled out the Self-Compassion Scale (SCS), Beck Depression Inventory (BDI), and Rumination Rating Scale (RRS). ECG (used to derive vmHRV) was acquired while resting and the square root of the mean squared differences of successive RR interval values (RMSSD) was calculated as measure of vmHRV.ResultsAs hypothesized, self-compassion was associated with lower ruminative tendencies. However, self-compassion was not associated with level of vmHRV. Several confounding variables were controlled for in the statistical analyses, and higher age predicted lower vmHRV across all statistical analyses.ConclusionThe results confirmed our hypothesis that higher self-compassion would be associated with lower ruminative tendencies in recurrent MDD. Contrary to our expectation, we did not find that the tendency to be more self-compassionate was associated with higher vmHRV. As such, higher self-compassion seems to relate with a lower tendency to ruminate about past mistakes and events but does not seem to relate to a flexible autonomic stress response (as indexed by higher vmHRV). Other potential explanatory factors for lower vmHRV in recurrent MDD is suggested as focus for exploration in future studies.
Psychometrics of the Patient Health Questionnaire (PHQ-9) in Uganda: A Systematic Review
Authors: Kaggwa Mark Mohan , Najjuka Sarah Maria , Ashaba Scholastic , Mamun Mohammed A. 
Published: March 2022

BackgroundDepression is screened by many psychological tools, whereas the Patient Health Questionnaire-9 (PHQ-9) is one of the most commonly used self-administered tools. Uganda is a culturally diverse country with a wide variety of tribes, ethnic groups, languages, and disease conditions; it is urgent to know the psychometrics of the used PHQ-9 across different cohorts. However, there is no prior review to assess its reliability in this culturally diverse country, where this review fulfills the knowledge gap.MethodsAdhering to the PRISMA guideline, a systematic search was performed in several databases (i.e., PubMed, Africa-Wide Information, AJOL, and PsycINFO, among others), and a total of 51 articles were included in this review, confirming the study inclusion criteria (e.g., using the PHQ-9).ResultsThe PHQ-9 has been used among individuals above 10 years and both genders, and the tool has been used most among the HIV patient group (n= 28). The tool is frequently administered by interviews and has been translated into several languages (mostly Luganda,n= 31). A cutoff of 10 was commonly used to identify clinical or major depression (n= 23), and its prevalence ranged from 8 to 67%. It has been validated for use in two populations, (i) HIV-positive participants and (ii) the general population attending a health facility. The sensitivity and specificity were 92 and 89%, respectively, at a cutoff score of 10, whereas 67 and 78%, respectively, at a cutoff score of 5. The Cronbach alpha ranged between 0.68 and 0.94.ConclusionThe PHQ-9 has been used in several studies in Uganda but validated in only two populations and is commonly used in one language. Thus, validation of the tool in various populations and languages is warranted to improve the tool's acceptance in Uganda.
Extraversion and Neuroticism on College Freshmen's Depressive Symptoms During the COVID-19 Pandemic: The Mediating Role of Social Support
Authors: Yu Tengxu , Hu Jinsheng 
Published: March 2022

ObjectiveThis study aims to explore the direct effects of extraversion and neuroticism on college freshmen's depressive symptoms and their indirect effects via social support under the background of COVID-19.MethodA total of 3,563 college freshmen were surveyed using the extraversion and neuroticism scales of the Chinese version of the Eysenck Personality Questionnaire (EPQ), the Chinese version of the Beck Depression Inventory-II (BDI-II), and the Social Support Rating Scale (SSRS). Partial correlation analyses and regression analyses were used.Results(1) Extraversion had a significant and negative predictive effect on depressive symptoms, while neuroticism positively predicted depressive symptoms. The interaction effect between extraversion and neuroticism on depressive symptoms was also significant. Neuroticism had a greater impact on depressive symptoms in college freshmen with low levels of extraversion. (2) Furthermore, social support partially mediated the relationships between extraversion and depressive symptoms, and neuroticism and depressive symptoms.ConclusionsExtraversion and neuroticism can directly affect college freshmen' s depressive symptoms, and have indirect effects via the mediating role of social support. Additionally, extraversion interacts with neuroticism, and extraversion plays a protective role in the effect of neuroticism on depressive symptoms. These findings help identify college freshmen at high risk of depression and design effective prevention or intervention measures for them.
Observation of the Intervention Effect of Biofeedback Therapy Combined With Cluster Nursing on Perioperative Constipation in Patients With Thoracolumbar Fracture
Authors: Luo Jin , Xie Nan , Yang Liping 
Published: March 2022

PurposeTo discuss the intervention effect of biofeedback therapy combined with cluster nursing on perioperative constipation in patients with thoracolumbar fracture.MethodsFrom June 2019 to June 2020, a total of 482 patients with thoracolumbar fracture who were treated by surgery in our department were selected. The random number table method was used to divide into experimental group (n = 241) and control group (n = 241). The control group was given routine constipation care, the experimental group was given biofeedback therapy combined with cluster nursing based on the control group. The constipation score, Bristol stool scale score, the short health questionnaire (SF-36) scale score, and the satisfaction of two groups were observed.ResultsThe constipation scores of the experimental group were lower than those of the control group, while the Bristol stool scale score, SF-36 score, and satisfaction degree of the experimental group were higher than those of the control group (p &lt; 0.05).ConclusionBiofeedback therapy combined with cluster nursing has a good intervention effect in perioperative constipation of patients with thoracolumbar fracture, which can reduce the degree of constipation, improve stool traits, improve the quality of life, and improve the satisfaction of patients.
Efektivitas Pembelajaran Daring dan Luring di SMP Negeri 3 Pleret
Authors: Sari Silvia Indah 
Published: March 2022

Penelitian dilatarbelakangi oleh sistem pembelajaran daring dan lurimg yang diterapkan di SMP Negeri 3 Pleret. Tujuan penelitian yaitu untuk mengetahui keefektifan pembelajaran daring dan luring di SMP Negeri 3 Pleret. Penelitian dilakukan dengfan menggunakan pendekatan kualitatif dan metode wawancara. Hasil dari penelitian menunjukkan 69,2 siswa berpendapat bahwa pembelajaran luring lebih efektif, sedangkan 30,1 siswa berpendapat sebaliknya. Begitu juga pendapat guru, sebanyak 62% menyatakan bahwa pembelajaran luring lebih efektif dibandingkan dengan pembelajaran daring. Proses pembelajaran daring dilakukan dengan menggunakan aplikasi WhatsApp grup, Google Formulir dan lainnya. Tatap muka dilakukan seminggu 2 kali untuk mengumpulkan tugas, modul, dan lainnya. Model pembelajaran yang digunakan yaitu model pembelajaran “discovery learning”. Model tersebut dimaksudkan agar siswa menjadi aktif dan tanggap dalam mengikuti proses pembelajaran. Media yang digunakan yaitu “Powtoon” serta media lain seperti Power Point dan Word Dokumen. Katakunci: proses, belajar, daring, luringAbstract: The background of the research is the online and offline learning system implemented at SMP Negeri 3 Pleret. The purpose of the study was to determine the effectiveness of online and offline learning at SMP Negeri 3 Pleret. The research was conducted using a qualitative approach and interview methods. The results of the study showed that 69.2 students thought that offline learning was more effective, while 30.1 students thought otherwise. Likewise, the opinion of teachers, as many as 62% stated that offline learning was more effective than online learning. The online learning process is carried out using the WhatsApp group application, Google Forms, and others. Face-to-face meetings are held twice a week to collect assignments, modules, and more. The learning model used is the "discovery learning" learning model. The model is intended so that students become active and responsive in following the learning process. The media used is "Powtoon" and other media such as PowerPoint and Word Documents. Keywords: process, learn, online, offline
Ragam Kolokial pada Kepolisian RI
Authors: Nabilah Farah , Mujianto Gigit 
Published: March 2022

Artikel ini akan mendeskripsikan variasi kolokial yang dipengaruhi faktor luar bahasa yang tedapat dalam interkasi SPEAKING. Metode deskriptif kualitatif digunakan dalam penelitian ini, dengan menitik beratkan peneliti sebagai instrumen penentu dalam penyelesian penelitian ini dengan deskripsi analisis terkait data. Data dalam penelitian ini berupa tuturan yang ditranskrip dari interaksi para penutur pada peritiwa turur tertentu. Teknik dalam penelitian ini yaitu deksriptif analisis yang digunakan untuk memaparkan penjelasan mengenai interaksi SPEAKING pada terapan variasi kolokial dalam bentuk tuturan yang ditranskrip. Hasil penelitian ini menujukkan penggunaan variasi bahasa kolokial yang ada dalam hierarki Kepolisian Republik Indonesia terdiri dari, (1) kolokial penghilangan huruf vokal dalam sebuah kata, (2) kolokial penghilangan huruf konsonan dalam sebuah kata, (3) penggunaan suku kata awal dan akhir pada sebuah kata, kemudian variasi bahasa kolokial dapat juga digunakan dalam situasi semi formal, dan formal. Katakunci: kolokial, SPEAKING, semi formal, dan formalAbstract This article will describe colloquial variations that are influenced by external factors in the SPEAKING interaction. The qualitative descriptive method was used in this study, with the emphasis on the researcher as a decisive instrument in completing this study with a description of the analysis related to the data. The data in this study are utterances that are transcribed from the interactions of speakers at certain speech events. The technique in this study is the descriptive analysis which is used to explain the explanation of the SPEAKING interaction in the application of colloquial variations in the form of transcribed speech. The results of this study indicate the use of colloquial language variations that exist in the hierarchy of the Indonesian National Police consisting of, (1) colloquial omission of vowels in a word, (2) colloquial omission of consonants in a word, (3) use of initial and final syllables in a word. a word, then colloquial language variations can also be used in semi-formal and formal situations.Keywords: Colloquial, SPEAKING, Semi-Formal, and Formal Situations
Pengembangan e-Modul Mata Kuliah Pembelajaran Bahasa Indonesia
Authors: Diana Purwati Zisca 
Published: March 2022

Artikel ini akan mendeskripsikan hasil analisis kebutuhan terhadap pengembangan rancangan e-modul mata kuliah Pembelajaran Bahasa Indonesia. Analisis kebutuhan ini merupakan bagian dari penelitian dan pengembangan (R&D). Metode penelitian yang digunakan adalah deskriptif kualitatif. Subjek penelitian adalah mahasiswa semester 4 tahun akademik 2020/2021. Pengumpulan data dilakukan dengan observasi, wawancara, kuesioner, dan analisis dokumen. Analisis data dilakukan dengan teknik analisis interaktif Miles-Huberman, yaitu pereduksian data, penyajian data, dan penarikan kesimpulan. Hasil penelitian, menunjukkan bahwa sumber belajar yang diperlukan mudah dipelajari dan dalam bentuk digital. Sebanyak 77,94% mahasiswa senang menggunakan e-modul sebagai sumber belajar karena praktis. Dengan demikian, dapat disimpulkan perlu dikembangkan e-modul sebagai sumber belajar dalam mata kuliah Pembelajaran Bahasa Indonesia.Kata kunci: analisis kebutuhan, e-modul, sumber belajar, bahasa Indonesia Abstract:This article will describe the results of the needs analysis on the development of the e-module design for Indonesian Language Learning courses. This needs analysis is part of research and development (R&D). The research method used is descriptive qualitative. The research subjects are 4th-semester students of the 2020/2021 academic year. Data were collected by observation, interviews, questionnaires, and document analysis. Data analysis was carried out using the Miles-Huberman interactive analysis technique, namely data reduction, data presentation, and conclusion drawing. The results showed that the learning resources needed were easy to learn and in digital form. As many as 77.94% of students are happy to use e-modules as a learning resource because it is practical. Thus, it can be concluded that it is necessary to develop e-modules as learning resources in Indonesian Language Learning courses.Keywords: needs analysis, e-module, learning resources, Indonesian language
Fabrication of high-entropy REBa2Cu3O7−δ thin films by pulsed laser deposition
Authors: Yamashita Aichi , Hashimoto Kazuki , Suzuki Shunta , Nakanishi Yusuke , Miyata Yasumitsu , Maeda Toshihiko , Mizuguchi Yoshikazu 
Published: March 2022

Abstract
Thin films of REBa2Cu3O7−δ
(RE123, RE: rare earth) having a high-entropy (HE) RE site were successfully fabricated by the pulsed laser deposition method. Solution various RE elements result in increasing configurational entropy of mixing. Critical current density of the HE films exceeds an order of 1.0 MA cm−2 under conditions of T < 20 K and μ
0
H < 7 T. Since the HE effects have a potential to an improvement of irradiation tolerance, the present results encourage further development of HE RE123 superconducting materials used in the environment with high magnetic fields and irradiation, for example in fusion reactors.
Penerapan Metode Pembelajaran Discovery Learning Dalam Meningkatkan Keterampilan Menulis Teks Berita Pada Siswa Kelas VIII SMPN 7 Mataram Tahun Ajaran 2017/2018
Authors: B. Airmah  
Published: March 2022

Penelitian Tindakan Kelas (PTK) ini dilakukan di Sekolah Menegah Pertama (SMP) Negeri 07 Mataram, Kelas VIII Tahun Pelajaran 2017/2018. Tujuan dari penelitian tindakan kelas ini adalah menganalisis penerapan metode discovery learning terhadap meningkatnya kemampuan siswa menulis teks berita.
Tujuan Penelitian yang ingin dicapai dalam pelaksanaan penelitan tindakan kelas ini adalah:1.Meningkatkan kompetensi guru Bahasa Indonesia dalam merancang dan mengaplikasikan pembelajaran dengan penggunaan metode discovery leaning. 2.Meningkatkan motivasi belajar Bahasa Indonesia siswa kelas VIII SMPN 7 Mataram yang antusias, mau bekerjasama,aktif selama proses pembelajaran, bisa menggunakan waktu secara efektif. 3.Meningkatkan keterampilan menulis siswa kelas VIII sehingga nilai rata-rata kelas diharapkan mencapai 75 sebagaimana yang telah ditetapkan dalam KKM. Penelitian ini dilakukan di Sekolah Menengah Pertama Negeri 7 Mataram, Jl. Bung Karno Pagutan Kota Mataram dengan subjek penelitian siswa kelas VIII di Sekolah Menengah Pertama Negeri 7 Mataram. Prosedur penelitian tindakan kelas dilaksanakan dalam dua siklus. Tiap-tiap siklus 2 kali pertemuan. Penelitian ini terdiri dari tahap perencanaan, tindakan, observasi dan refleksi. Alokasi waktu tahap tindakan yang berupa proses pembelajaran adalah 2 x 40 menit. Pengumpulan data dengan teknik tes dan non tes berupa observasi atau pengamatan yang dilakukan oleh siswa. Analisis datanya menggunakan deskriptif kualitatif dengan teknik deskriptif prosentase. Berdasarkan hasil penelitian dapat disimpulkan bahwa Pembelajaran dengan Metode metode discovery learning dapat meningkatkan keterampilan menulis teks berita pada siswa kelas VIII SMPN 7 Mataram.
PENGARUH BUDAYA ORGANISASI TERHADAP KINERJA PEGAWAI PADA KANTOR KEMENTERIAN AGAMA (KEMENAG) KABUPATEN BIMA
Authors: Nuranisyah dan Firmansyah Kusumayadi  
Published: March 2022

Penelitian ini bertujuan untuk mengetahui pengaruh budaya organisasi terhadap kinerja pegawai pada Kantor Kementerian Agama Kab. Bima. Instrumen penelitian kuesioner. Teknik skor yang digunakan dalam kuesioner penelitian ini adalah skala Likert. Populasi penelitian seluruh pegawai Kementerian Agama (KEMENAG) Kabupaten Bima. Selanjutnya untuk menentukan ukuran sampel menggunakan teknik pengambilan sampel puposive sampling dimana populasi dijadikan sampel berdasarkan kriteria dengan jumlah sampel sebanyak 34 PNS. Hasil penelitian menunjukkan bahwa budaya Organisasi berpengaruh positif terhadap kinerja pegawai.
Kebenaran, Keyakinan dan Moralitas Manusia Rasional
Authors: Muslikh Muslikh 
Published: March 2022

Tindakan radikalisme dan terorisme yang menghalalkan segala cara adalah suatu tindakan immoralitas-irrasional yang tidak berdasarkan fakta dan kebenaran. Idealnya apa yang dilakukan oleh seseorang seharusnya berdasarkan suatu kebenaran hasil dari pertimbangan akal dan pengalaman empirisnya di lapangan. Jika kebenaran sudah didapatkan, maka skeptisisme akan hilang, dan lahirlah suatu keyakinan. Dengan keyakinannya secara rasional seharusnya orang melakukan suatu tindakan dalam koridor “benar, baik dan indah”, sehingga ia dapat hidup secara harmonis dalam suatu tatanan kehidupan masyarakat. Dengan demikian sejatinya manusia rasional adalah pribadi yang mampu menselaraskan antara pikiran, perasaan dan tindakan yang menghasilkan kebenaran, keyakinan dan sikap sebagi pribadi yang utuh. Suatu kesalahan fatal jika tindakan yang dikuatkan oleh keyakinan yang berubah menjadi “doktrin” tidak berdasarkan pada fakta dan kebenaran, sehingga berimplikasi pada tindakan immoralitas yang bertentangan dengan nilai-nilai kemanusiaan. Tujuan penelitian ini adalah menjelaskan konstruksi berfikir manusia rasional yang pikiran dan perbuatannya menggambarkan manusia yang bermoral. Metode yang digunakan dalam penelitian ini adalah library research dengan kajian-kajian referensi yang berkaitan dengan tema permasalahan. Hasil dari penelitian ini adalah karakteristik manusia rasional yang tindakannya berdasarkan fakta dan kebenaran, yang selaras dengan nilai etika dan estetika. Konstruksi berpikir ilmiah ini penting karena berimplikasi sangat luas terhadap kehidupan manusia dalam bermasyarakat, berbangsa dan bernegara serta dalam tatanan kehidupan global.