bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exhumation of plutons controlled by boundary faults: Insights from the kinematics, microfabric, and geochronology of the Taibai shear zone, Qinling Orogen, China
Authors: Cheng Chao , Sun Shengsi , Dong Yunpeng , Zhang Bin , Guo Zhao 
Published: February 2022

Abstract
The Taibai granitic plutons lie between the Taibai ductile shear zone to the north and the Shangdan suture to the south. The deformation mechanism of the ductile shearing is crucial to understanding the exhumation processes of the multiple plutons that formed after the Late Mesozoic period. Geological investigations, microstructures, and kinematic vorticity calculations indicate that the Taibai shear zone deformed in response to pure shear-dominated (54%–65%) transpression and top-to-NW shear sense as a result of NE–SW oblique contractional tectonics. The quartz crystallographic preferred orientations of the prism &lt;a&gt; slip system, the grain boundary migration, and sub-grain rotation dynamic recrystallization of quartz—combined with the plagioclase–hornblende thermometer—constrain the main deformation temperatures to a range of 400–650 °C, which suggests amphibolite to greenschist facies conditions. In addition, it is extremely likely that the mylonites experienced late-stage, lower temperature deformation as demonstrated by the sporadic bulging recrystallization, the quartz basal &lt;a&gt; slip system, and the two-feldspar geothermometer calculation. The samples collected from the weakly deformed mylonitic granite pluton and the undeformed quartz-feldspathic dike that intruded into the mylonites yield zircon U–Pb ages of 129 ± 1 Ma and 115 ± 1 Ma, respectively. This information, with the lower intercept ages of ca. 120 Ma obtained from the mylonite samples, suggests that the ductile shearing probably occurred from ca. 129 Ma to 115 Ma. Combined with the regional geological data, these findings suggest that the Taibai shear zone and the Shangdan suture accommodated the oblique upward extrusion of the Taibai plutons during Early Cretaceous time.
The late Holocene Nealtican lava-flow field, Popocatépetl volcano, central Mexico: Emplacement dynamics and future hazards
Authors: Ramírez-Uribe Israel , Siebe Claus , Chevrel Magdalena Oryaëlle , Ferres Dolors , Salinas Sergio 
Published: February 2022

Abstract
Popocatépetl, one of the most hazardous volcanoes worldwide, poses significant threats for nearby populations in central Mexico. Therefore, it is important to reconstruct its eruptive history, including estimates of lava-flow emplacement times and their rheological properties. These studies define possible future eruptive scenarios and are necessary to mitigate the risk. Stratigraphic studies of the cal 350–50 B.C. Lorenzo Plinian pumice sequence indicate that effusive activity (Nealtican lava-flow field) occurred shortly after explosive activity, reflecting drastic changes in the eruptive dynamics. It was likely due to the efficient degassing of the magma during the Plinian phase and a decrease of magma ascent and decompression rates. Magma mixing, fractional crystallization, and a minor crust assimilation are the processes controlling the differentiation of the Nealtican lavas. We used lava chemical and mineralogical composition to estimate lava-flow viscosities, and used high-resolution elevation data to estimate emplacement times. Results indicate that lava viscosities of andesites and dacites ranged from 109 to 1012 Pa·s and emplacement durations were between ~1 and ~29 years, depending on the flow unit and morphological method employed. Considering the entire volume of emitted lava (4.2 km3) and a mean output rate of ~1 m3/s to ~15 m3/s, we estimated that the effusive phase that produced the Nealtican lava-flow field may have lasted ~35 years. This eruption had a considerable impact on pre-Hispanic settlements around the volcano, whose population exodus and relocation probably contributed to the rise of important cities in central Mexico, such as Teotihuacán and Cholula.
Oligocene onset of uplift and inversion of the Cascadia forearc basin, southern Oregon Coast Range, USA
Authors: Darin Michael H. , Armentrout John M. , Dorsey Rebecca J. 
Published: February 2022

Abstract
An extensive detrital zircon U-Pb data set (n = 6324 dates) from Eocene to Miocene sandstones and modern river sands establishes the onset of arc magmatism and forearc uplift along the Cascadia convergent margin in southwestern Oregon (United States). Middle to late Eocene marine strata in the Coos Bay area were primarily sourced from the Klamath Mountains and coeval Clarno-Challis volcanoes in central Oregon and/or Idaho. Ancestral Cascades arc magmatism initiated at 40 Ma and supplied sediment to a broad forearc basin in western Oregon during late Eocene time. Major reduction of Ancestral Cascades arc (40–12 Ma) and Clarno-Challis (52–40 Ma) zircon in the Tunnel Point Sandstone (ca. 33–30 Ma) records the isolation of the Coos Bay area from the Ancestral Cascades arc due to Oligocene onset of forearc uplift, basin inversion, and emergence of the southern Oregon Coast Range. The Tarheel formation (ca. 18–15 Ma) is characterized by disappearance of Ancestral Cascades arc zircon and a substantial increase in Clarno-Challis zircon recycled from underlying forearc strata. The ~15–20 m.y. delay between subduction initiation (ca. 49–46 Ma) and the onset of forearc uplift (ca. 33–30 Ma) supports insights from thermomechanical models that identify tectonic underplating and thermally activated lower-crustal flow as major drivers of deformation and uplift in active forearc regions.
Spatial codistribution of HIV, tuberculosis and malaria in Ethiopia
Authors: Alene Kefyalew Addis , Elagali Ahmed , Barth Dylan D , Rumisha Susan F , Amratia Punam , Weiss Daniel J , Atalell Kendalem Asmare , Erena Andargachew Kumsa , Gething Peter W , Clements Archie C A 
Published: February 2022

BackgroundHIV, tuberculosis (TB) and malaria are the three most important infectious diseases in Ethiopia, and sub-Saharan Africa. Understanding the spatial codistribution of these diseases is critical for designing geographically targeted and integrated disease control programmes. This study investigated the spatial overlap and drivers of HIV, TB and malaria prevalence in Ethiopia.MethodsHIV, TB and malaria data were obtained from different nationwide prevalence surveys, and geospatial covariates were obtained from publicly available sources. A Bayesian model-based geostatistical framework was applied to each survey leveraging the strength of high-resolution spatial covariates to predict continuous disease-specific prevalence surfaces and their codistribution.ResultsThe national prevalence was 1.54% (95% CI 1.40 to 1.70) for HIV, 0.39% (95% CI 0.34 to 0.45) for TB and 1.1% (95%CI 0.95 to 1.32) for malaria. Substantial subnational variation was predicted with the highest HIV prevalence estimated in Gambela (4.52%), Addis Ababa (3.52%) and Dire Dawa (2.67%) regions. TB prevalence was highest in Dire Dawa (0.96%) and Gambela (0.88%), while malaria was highest in Gambela (6.1%) and Benishangul-Gumuz (3.8%). Spatial overlap of their prevalence was observed in some parts of the country, mainly Gambela region. Spatial distribution of the diseases was significantly associated with healthcare access, demographic, and climatic factors.ConclusionsThe national distribution of HIV, TB and malaria was highly focal in Ethiopia, with substantial variation at subnational and local levels. Spatial distribution of the diseases was significantly associated with healthcare access, demographic and climatic factors. Spatial overlap of HIV, TB and malaria prevalence was observed in some parts of the country. Integrated control programmes for these diseases should be targeted to these areas with high levels of co-endemicity.
Global disparities in public health guidance for the use of COVID-19 vaccines in pregnancy
Authors: Zavala Eleonor , Krubiner Carleigh B , Jaffe Elana F , Nicklin Andrew , Gur-Arie Rachel , Wonodi Chizoba , Faden Ruth R , Karron Ruth A 
Published: February 2022

IntroductionGaps in information about the safety and efficacy of COVID-19 vaccines in pregnancy have led to substantial global variation in public health guidance regarding the use of COVID-19 vaccines in pregnancy over the course of the pandemic.MethodsWe conducted systematic screenings of public health authorities’ websites across 224 countries and territories every 3 weeks to track the development of policies on COVID-19 vaccine use in pregnancy. Policies were categorised using a 1–5 permissiveness scale, with 1 indicating policies that recommended use, and 5 indicating policies that recommended against use.ResultsAs of 30 September 2021, 176 countries/territories had issued explicit guidance on COVID-19 vaccine use in pregnancy, with 38% recommending use, 28% permitting use, 15% permitting use with qualifications, 2% not recommending but with exceptions, and 17% not recommending use whatsoever. This represented a significant shift from May 2021, when only 6% of countries/territories with such policies recommended the use of COVID-19 vaccines in pregnancy (p<0.001). However, no policy positions could be found for 21% of all countries and territories, the vast majority being low and middle income. Policy positions also varied widely by vaccine product, with Pfizer/BioNTech and Moderna vaccines being most commonly recommended or permitted.ConclusionOur study highlights the evolution of policies regarding COVID-19 vaccine use in pregnancy over a 5-month period in 2021, the role of pregnancy-specific data in shaping these policies and how inequities in access for pregnant people persist, both within countries and globally.
Utilisation of immediate postpartum family planning among postpartum women at public hospitals of North Shoa Zone, Ethiopia: a cross-sectional study
Authors: Silesh Mulualem , Lemma Tesfanesh , Abdu Samuel , Fenta Belete , Tadese Mesfin , Taye Birhan Tsegaw 
Published: February 2022

ObjectiveThis study aimed to assess the prevalence of immediate postpartum family planning utilisation and the associated factors among postpartum women at public hospitals of North Shoa Zone, Ethiopia.Design and methodsA facility-based cross-sectional study was conducted in 1–30 May 2020. Systematic random sampling technique was used to select the participants. Data were collected through a face-to-face interview using a structured and pretested questionnaire. Univariate and multivariable logistic regression analyses were employed. In multivariable logistic regression analysis, p<0.05 and adjusted OR (AOR) with 95% CI were used to declare statistically significant factors.Setting and participantsThe study was conducted at public hospitals of North Shoa Zone, Ethiopia. A total of 394 postpartum women within 48 hours after giving birth before discharge from the selected hospitals were enrolled in the study.OutcomeImmediate postpartum family planning utilisation (used or not used).ResultsOf the total 394 participants, 84 (21.3%) used immediate postpartum family planning. The factors associated with immediate postpartum family planning utilisation were women’s age (30–34 years) (AOR: 0.118; 95% CI 0.023 to 0.616), planning status of pregnancy (AOR: 3.175; 95% CI 1.063 to 9.484), reproductive intention (AOR: 5.046; 95% CI 1.545 to 16.479), partner support (AOR: 4.293; 95% CI 1.181 to 15.61), attitude towards family planning (AOR: 2.908; 95% CI 1.081 to 7.824) and maternal satisfaction with intrapartum care (AOR: 6.243; 95% CI 2.166 to 17.994).ConclusionIn the study area, only less than a quarter of postpartum women used immediate postpartum family planning. Therefore, enhancing immediate postpartum family planning utilisation, strengthening community awareness to develop a favourable attitude towards family planning, promoting partner involvement in family planning and ensuring maternal satisfaction during intrapartum care are essential.
Prevalence and risk factors of senile pruritus: a systematic review and meta-analysis
Authors: Chen Shi , Zhou Faquan , Xiong Yiquan 
Published: February 2022

ObjectivesTo systematically assess the prevalence and risk factors for senile pruritus (SP) in the elderly (≥60 years of age).DesignA meta-analysis was used to pool the prevalence and risk factors for SP estimated from individual studies. Four subgroup analyses were conducted to explore the prevalence for SP in different age, sex, research sites and region.Setting, participants and measuresSP reduces quality of life in the elderly, yet the worldwide prevalence is unclear. Moreover, the risk factors for SP are controversial. Data from cross-sectional studies, case–control studies, longitudinal studies and cohort studies that reported the prevalence or the risk factors for SP were collected by searching nine electronic databases up to October 2020, including Web of Science, PubMed, Embase, Cochrane Library, CINAHL, CBM, CNKI, Wanfang and VIP. Two reviewers independently screened studies according to the inclusion and exclusion criteria, extracted data and assessed methodological quality. Data analysis was performed using Stata V.15.1 software.ResultsSeventeen studies involving 28 666 participants were included. The overall pooled prevalence of SP was 21.04% (95% CI 11.37% to 32.72%). In addition, the results showed that smoking, excessive drinking and monophagism were possible risk factors for SP, with pooled ORs of 1.26 (95% CI 1.14 to 1.40), 25.03 (95% CI 18.28 to 34.25) and 1.22 (95% CI 1.12 to 1.33), respectively.ConclusionsThe overall prevalence of SP was high. Smoking, excessive drinking and monophagism were possible risk factors for SP.PROSPERO registration numberCRD42019143295.
Does the risk of chronic low back pain depend on age at menarche or menopause? A population-based cross-sectional and cohort study: the Trøndelag Health Study
Authors: Heuch Ingrid , Heuch Ivar , Hagen Knut , Storheim Kjersti , Zwart John-Anker 
Published: February 2022

ObjectiveIn most population-based studies of low back pain (LBP), women have a higher risk than men, possibly reflecting hormonal influences. The aim of this study was to explore associations between age at menarche and menopause and risk of chronic LBP.DesignPopulation-based cross-sectional and cohort study designs.SettingThe HUNT2 and HUNT3 medical surveys of the entire population of Nord-Trøndelag County in Norway.Main outcome measurePrevalence or risk of chronic LBP, defined as LBP persisting at least 3 months continuously during last year.ParticipantsAssociations between age at menarche and prevalence of chronic LBP were examined in cross-sectional data from HUNT2, comprising 27 697 women aged 20–69 years, with 7300 women reporting LBP. The corresponding cohort data included 11 659 women without LBP at baseline in HUNT2, with 2353 women reporting LBP at follow-up 11 years later in HUNT3. Cross-sectional data on age at menopause or premenopausal status included 11 332 women aged 40–69 years, with 3439 women reporting chronic LBP. Corresponding cohort data included 7893 women without LBP at baseline, of whom 1100 developed LBP.MethodsAssociations between age at menarche or menopause and risk of chronic LBP were examined by generalised linear modelling.ResultsA U-shaped association was indicated between age at menarche and risk of chronic LBP, both in the cross-sectional and cohort studies. Age at menarche ≤11 years was associated with an increased risk of chronic LBP, with a relative risk of 1.32 (95% CI 1.15 to 1.52), compared with age 14 years at menarche, after relevant adjustments. Corresponding cross-sectional crude absolute risks were 32% and 25%, respectively. No association was established between age at menopause and risk of LBP. Being premenopausal had no influence on risk.ConclusionsIn contrast to results for age at menopause, the association with age at menarche suggests that hormonal factors affect the risk of LBP.
Protocol for a systematic review of the financial burden experienced by people affected by head and neck cancer
Authors: McCaffrey Nikki , Engel Lidia 
Published: February 2022

IntroductionHead and neck cancer (HNC) is the seventh most common cancer worldwide. Treatment may be associated with the inability to work and substantial out-of-pocket expenses. However, to date, there is little research synthesising quantitative evidence on the financial burden experienced by people affected by HNCs, including family members and informal carers. The purpose of this systematic review is to estimate out-of-pocket costs, reduced or lost income and informal care costs associated with HNC, identify categories of financial burden and investigate which costs predominate when considering financial burden in this population.Methods and analysisA comprehensive search of peer-reviewed literature will be conducted for articles published from 01/01/2010 to 19/03/2021 (CINAHL, Cochrane library, EconLit, Embase, Medline Complete). Published, English-language articles describing primary and secondary research directly related to the topic and quantitative cost data will be included. One researcher will complete the searches and screen results for potentially eligible studies. Three other researchers will independently screen the titles and abstracts of a subset of 30% citations, that is, 10% each. Full text articles will be independently screened by three reviewers. Any disagreement will be resolved by consensus among the team. Study and patient characteristics, cost categories and financial burden will be independently extracted by one reviewer and checked by a second. Methodological quality will be evaluated independently by two reviewers. Descriptive analyses will be undertaken and a narrative summary of the included studies will be provided.Ethics and disseminationEthics approval is not required to conduct this research because this is a planned systematic review of published literature. Findings will be presented at leading cancer and health economic conferences, published in a peer-reviewed journal and disseminated via website postings and social media channels.Systematic review registration numberCRD42021252929.
DEPEND study protocol: early detection of patients with pancreatic cancer – a pilot study to evaluate the utility of faecal elastase-1 and 13C-mixed triglyceride breath test as screening tools in high-risk individuals
Authors: Afolabi Paul Remi , McDonnell Declan , Byrne Christopher D , Wilding Sam , Goss Victoria , Walters Jocelyn , Hamady Zaed Z 
Published: February 2022

IntroductionPancreatic cancer (PC) is the fifth leading cause of cancer-related death in the UK. The incidence of PC is increasing, with little or no improvement in overall survival and the best chance for long-term survival in patients with PC relies on early detection and surgical resection. In this study, we propose the use of a diagnostic algorithm that combines tests of pancreatic exocrine function (faecal elastase-1 (FE-1) test and the 13C-mixed triglyceride (13C-MTG) breath test) to identify patients with PC that urgently needs imaging studies.Methods and analysisThis prospective pilot (proof of concept) study will be carried out on 25 patients with resectable PC, 10 patients with chronic pancreatitis and 25 healthy volunteers. This study will construct a predictive algorithm for PC, using two tests of pancreatic exocrine function, FE-1 test and the 13C-MTG breath test. Continuous flow isotope ratio mass spectrometry in the 13C-MTG breath test will be used to analyse enriched 13CO2 in exhaled breath samples. The additional predictive benefit of other potential biomarkers of PC will also be considered. Potential biomarkers of PC showing abilities to discriminate between patients with PC from healthy subjects or patients with chronic pancreatitis will be selected by metabolomic analysis.Ethics and disseminationThe study was approved by the North of Scotland Research and Ethics Committee on 1 October 2020 (reference: 20/NS/0105, favourable opinion granted). The results will be disseminated in presentations at academic national/international conferences and publication in peer-review journals.
Prospective analyses of sex/gender-related publication decisions in general medical journals: editorial rejection of population-based women’s reproductive physiology
Authors: Kalidasan Dharani , Goshtasebi Azita , Chrisler Joan , Brown Helen L , Prior Jerilynn C 
Published: February 2022

ObjectiveTo assess whether editorial desk rejection at general medical journals (without peer review) of two clinical research manuscripts may relate to author gender or women’s physiology topics. Given evidence for bias related to women in science and medicine, and editorial board attitudes, our hypothesis was that submissions by women authors, on women’s reproductive, non-disease topics received differential editorial assessment.DesignA prospective investigation of publications, author gender and topics in general medical journals in two issues following the editorial rejections of two clinical research manuscripts by five major English-language general medical journals. The rejected manuscripts (subsequently published in lower impact journals) described research funded by national granting bodies, in population-based samples, authored by well-published women scientists at accredited institutions and describing innovative women’s reproductive physiology results.SettingTertiary academic medical centre.Main outcome measuresAll clinical research published in the two issues following rejection date by each of the five major general medical journals were examined for first/senior author gender. The publication topic was assessed for its gendered population relevance, whether disease or physiology focused, and its funding. Rejection letters assessed editor gender and status.ResultsWomen were underrepresented as original research authors; men were 84% of senior and 69% of first authors. There were no, non-disease focused publications relating to women’s health, although most topics were relevant to both genders. The majority (80%) of rejection letters appeared to be written by junior-ranked women editors.ConclusionSex/gender accountability is necessary for clinical research-based editorial decisions by major general medical journals. Suggestions to improve gender equity in general medical journal publication: (1) an editorial board sex/gender champion with power to advocate for manuscripts that are well-performed research of relevance to women’s health/physiology; (2) an editorial rejection adjudication committee to review author challenges; and (3) gender parity in double-blind peer review.