bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Diagnostic Significance of the BI‐RADS Classification Combined With Automated Breast Volume Scanner and Shear Wave Elastography for Breast Lesions
Authors: Ren Tiantian , Li Xiaoran , Xiang Yu , Zhang Yuanyuan , Jiang Mingfei , Zhang Chaoxue 
Published: December 2022

ObjectiveWe herein compared the diagnostic accuracy of the BI‐RADS, ABVS, SWE, and combined techniques for the classification of breast lesions.MethodsBreast lesions were appraised using the BI‐RADS classification system as well as the combinations of BI‐RADS plus ABVS (BI‐RADS + ABVS) and BI‐RADS plus SWE (BI‐RADS + SWE), and both methods (BI‐RADS + ABVS + SWE) by two specialties Medical Ultrasound physician. The Fisher's exact and χ2 tests were performed to compare the degree of malignancy for the various methods with a pathology ground truth. Receiver operating characteristic curves (ROC) were generated and the corresponding area under the curve (AUC) values were determined to test the diagnostic efficacy of the various methods and identify the optimal SWE cut‐off indicative of malignancy.ResultsThe incidence of the retraction phenomenon on ABVS images of the malignant group was significantly higher (P < .001) than that of the benign group. The specificity, sensitivity, and positive and negative predictive values of the BI‐RADS classification were 88.72, 79.38, 83.70, and 85.50%, respectively. BI‐RADS plus SWE‐Max exhibited enhanced specificity, sensitivity, and positive and negative predictive values of 88.72, 92.78, 85.70, and 94.40%, respectively. Similarly, when BI‐RADS + ABVS was utilized, the sensitivity and negative predictive value increased to 95.88 and 96.40%, respectively. BI‐RADS + ABVS + SWE possessed the highest overall sensitivity (96.91%), specificity (94.74%), and positive (93.10%) and negative (97.70%) predictive values from all four indices.ConclusionABVS and SWE can reduce the subjectivity of BI‐RADS. As a result, BI‐RADS + ABVS + SWE resulted in the best diagnostic accuracy.
Selective synthesis of 2‐substituted 2,3‐dihydroquinazolin‐4(1H)‐ones and quinazolin‐4(3H)‐ones catalyzed by Schiff base dioxomolybdenum(VI) complex
Authors: Feng Mengmeng , Yan Qingmin , Yang Lan , Ye Yanan , Liu Gang , Wang Weili 
Published: December 2022

AbstractSchiff base dioxomolybdenum(VI) complex is found to be a novel and efficient catalyst for the selective synthesis of 2‐substituted 2,3‐dihydroquinazolin‐4(1H)‐ones via condensation of 2‐aminobenzamide with aldehydes or ketones. Also, this catalyst is also found to be efficient for the construction of quinazolin‐4(3H)‐ones while in the presence of hydrogen peroxide as oxidant. At higher temperature the aldehydes undergo an oxidative cyclization reaction affording the quinazolin‐4(3H)‐ones. Herein we report a novel protocol with practical simplicity, broad substrate scope, good selectivity, moderate to excellent yields, and low catalyst loading (0.5% mol).
Heeding emotions or seeking challenges? Family support processes cultivate consumers' emotion‐ and problem‐focused support‐seeking
Authors: Moisio Risto , Beruchashvili Mariam 
Published: December 2022

AbstractThis research explores how families shape consumers' support‐seeking from businesses' employees and other customers. Findings from a qualitative study of Weight Watchers uncover that some families trigger support‐seeking focused on attenuating emotions arising from the source of stress (emotion‐focused support‐seeking), while other families foster support‐seeking related to attenuating the cause(s) of stress itself (problem‐focused support‐seeking). Consumers' support‐seeking reflects whether they experience their families' support as caring and responsive to their needs. As such, this research informs the substantive understanding of how consumers cope with consumption‐induced stress. Theoretically, this research contributes to coping literature in marketing with its conceptualization of emotion‐ and problem‐focused support‐seeking. This work also contributes to marketing literature on social support, expanding and revising the literature's explanation about when and how support from primary sources (e.g., family) is related to consumers' support‐seeking from businesses' employees and customers. Managerially, this work is relevant to businesses in consumer health domain. The key implication is that to enhance customer satisfaction and retention, businesses ought to improve the alignment between their services and consumers' support‐seeking tendencies.
Motion‐resolved real‐time 4D flow MRI with low‐rank and subspace modeling
Authors: Sun Aiqi , Zhao Bo , Zheng Yichen , Long Yuliang , Wu Peng , Wang Bei , Li Rui , Wang He 
Published: December 2022

PurposeTo develop a new motion‐resolved real‐time four‐dimensional (4D) flow MRI method, which enables the quantification and visualization of blood flow velocities with three‐directional flow encodings and volumetric coverage without electrocardiogram (ECG) synchronization and respiration control.MethodsAn integrated imaging method is presented for real‐time 4D flow MRI, which encompasses data acquisition, image reconstruction, and postprocessing. The proposed method features a specialized continuous ‐space acquisition scheme, which collects two sets of data (i.e., training data and imaging data) in an interleaved manner. By exploiting strong spatiotemporal correlation of 4D flow data, it reconstructs time‐series images from highly‐undersampled ‐space measurements with a low‐rank and subspace model. Through data‐binning‐based postprocessing, it constructs a five‐dimensional dataset (i.e., x‐y‐z‐cardiac‐respiratory), from which respiration‐dependent flow information is further analyzed. The proposed method was evaluated in aortic flow imaging experiments with ten healthy subjects and two patients with atrial fibrillation.ResultsThe proposed method achieves 2.4 mm isotropic spatial resolution and 34.4 ms temporal resolution for measuring the blood flow of the aorta. For the healthy subjects, it provides flow measurements in good agreement with those from the conventional 4D flow MRI technique. For the patients with atrial fibrillation, it is able to resolve beat‐by‐beat pathological flow variations, which cannot be obtained from the conventional technique. The postprocessing further provides respiration‐dependent flow information.ConclusionThe proposed method enables high‐resolution motion‐resolved real‐time 4D flow imaging without ECG gating and respiration control. It is able to resolve beat‐by‐beat blood flow variations as well as respiration‐dependent flow information.
Safety and activity of anti‐CD14 antibody IC14 (atibuclimab) in ALS: Experience with expanded access protocol
Authors: Gelevski Dario , Addy Grace , Rohrer Margot , Cohen Caroline , Roderick Aimee , Winter Allison , Carey Judith , Scalia Jennifer , Yerton Megan , Weber Harli , Doyle Michael , Parikh Neil , Kane Geli , Ellrodt Amy , Burke Katherine , D'Agostino Derek , Sinani Ervin , Yu Hong , Sherman Alexander , Agosti Jan , Redlich Garry , Charmley Patrick , Crowe David , Appleby Mark , Ziegelaar Brian , Hanus Katherine , Li Zhenhua , Babu Suma , Nicholson Katharine , Luppino Sarah , Berry James , Baecher‐Allan Clare , Paganoni Sabrina , Cudkowicz Merit 
Published: December 2022

AbstractIntroduction/AimsIC14 (atibuclimab) is a monoclonal anti‐CD14 antibody. A previous phase 1 trial of 10 participants with amyotrophic lateral sclerosis (ALS) demonstrated initial safety of IC14 in an acute treatment setting. We provided long‐term treatment with IC14 to individuals with ALS via an expanded access protocol (EAP) and documented target engagement, biomarker, safety, and disease endpoints.MethodsParticipants received intravenous IC14 every 2 weeks. Consistent with United States Food and Drug Administration guidelines, participants were not eligible for clinical trials and the EAP was inclusive of a broad population. Whole blood and serum were collected to determine monocyte CD14 receptor occupancy (RO), IC14 levels, and antidrug antibodies. Ex vivo T‐regulatory functional assays were performed in a subset of participants.ResultsSeventeen participants received IC14 for up to 103 weeks (average, 30.1 weeks; range, 1 to 103 weeks). Treatment‐emergent adverse events (TEAEs) were uncommon, mild, and self‐limiting. There were 18 serious adverse events (SAEs), which were related to disease progression and unrelated or likely unrelated to IC14. Three participants died due to disease progression. Monocyte CD14 RO increased for all participants after IC14 infusion. One individual required more frequent dosing (every 10 days) to achieve over 80% RO. Antidrug antibodies were detected in only one participant and were transient, low titer, and non‐neutralizing.DiscussionAdministration of IC14 in ALS was safe and well‐tolerated in this intermediate‐size EAP. Measuring RO guided dosing frequency. Additional placebo‐controlled trials are required to determine the efficacy of IC14 in ALS.
Core–shell electrospun fiber architecture used as a nanoreactor to synthesize conjugated polymers
Authors: Miranda Diego Oliveira , Dorneles Matheus Figueiredo , Oréfice Rodrigo Lambert 
Published: December 2022

AbstractChemical reactions in a confined nanometer‐sized space can have a dramatic impact on conversion, reaction rate and macromolecular texture. In this work, the idea of synthesizing conjugated polymers (polyaniline, PANI) within the core of a core–shell submicron electrospun fiber was tested. To this end, acrylamide/acrylic acid solution containing ammonium persulfate was photopolymerized during electrospinning to prepare the shell of a core–shell electrospun fiber, while the core was produced based on an aniline‐rich solution. Polymerization of aniline occurred during the electrospinning through the contact of ammonium persulfate and aniline at the core of the newly formed fibers as observed by AFM electrical current mode and by Fourier transform infrared results that showed the presence of a highly doped and conductive emeraldine PANI. The ability of the shell of the fibers to swell in water and to lead to materials with low elastic modulus, as common hydrogels, was also detected through AFM images and indentation curves in water. © 2022 Society of Industrial Chemistry.
Influence of copolymer composition on the properties of soluble poly(aniline‐co‐2‐[2‐chloro‐1‐methylbut‐2‐en‐1‐yl]aniline)s
Authors: Latypova Lyaysan R. , Andriianova Anastasiia N. , Usmanova Gulsum S. , Salikhov Renat B. , Mustafin Akhat G. 
Published: December 2022

AbstractOxidative polymerization of aniline and 2‐(2‐chloro‐1‐methylbut‐2‐en‐1‐yl)aniline gave corresponding hitherto unknown copolymers with various compositions. The copolymers were studied by several techniques, including UV–visible spectroscopy, Fourier transform IR spectroscopy, cyclic voltammetry, thermal analysis and SEM. Copolymerization of aniline with an ortho‐substituted aniline derivative leads to the appearance of luminescence whose intensity increases with growth in the content of the substituted monomer units. It has been shown that the solubility of the copolymers obtained is determined by their composition. It has been found that the temperature of the start of thermal destruction of the copolymers increases with an increase in the content of a functionalized monomeric aniline therein. The solubility of the copolymers makes it possible to create homogeneous thin films and use them as the active layer in resistive gas sensors. © 2022 Society of Industrial Chemistry.
Development and validation of a stability‐indicating reversed‐phase–high‐performance liquid chromatography method for quantification of 2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a from lipid‐polymeric hybrid nanoparticles
Authors: Pradhan Rajesh , Dubey Sunil Kumar , Puri Anu , Taliyan Rajeev 
Published: December 2022

Abstract2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a is a second‐generation, lipophilic, chlorin‐based photosensitizer currently used for various types of solid cancer including breast, esophageal, neck, and head cancer, etc. The aim of the present work was to develop a sensitive and robust reversed‐phase–high‐performance liquid chromatography–ultraviolet detection method for the determination of 2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a to explore in vitro‐based applications including encapsulation, loading, drug release, and stability studies, and also could be utilized for the selective analysis of 2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a from developed lipid polymer hybrid nanoparticle. The developed reversed‐phase–high‐performance liquid chromatography–ultraviolet detection method was validated in terms of linearity, accuracy, precision, stability, and robustness as per standard guidelines. The developed method exhibited linearity ranging from 50 to 2000 ng/ml with an R2 value of 0.999. The limit of detection and limit of quantitation value of the developed method was found to be 14.03 and 42.80 ng/ml, respectively. Also, degradation studies revealed that 2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a degraded quickly under basic conditions compared to other stability conditions (i.e., acidic, oxidative, temperature, etc.). Furthermore, the developed drug‐loaded lipid polymer hybrid nanoparticle showed an average size of 123.03 nm (polydispersity index = 0.253) with an encapsulation efficiency of 70.23%. Cell cytotoxicity assay of lipid polymer hybrid nanoparticle showed significant cancer cell death equivalent to 2‐fold higher than the free drug. In conclusion, the developed reversed‐phase–high‐performance liquid chromatography–ultraviolet detection analytical method was found to be sensitive and reliable for the determination of free 2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a and 2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a content in loaded lipid polymer hybrid nanoparticle. Thereby, opening the avenues for future research to explore the detailed physiochemical and formulation designing for the 2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a.
RATE: A model‐based testing approach that combines model refinement and test execution
Authors: Bombarda Andrea , Bonfanti Silvia , Gargantini Angelo , Lei Yu , Duan Feng 
Published: December 2022

AbstractIn this paper, we present an approach to conformance testing based on abstract state machines (ASMs) that combines model refinement and test execution (RATE) and its application to three case studies. The RATE approach consists in generating test sequences from ASMs and checking the conformance between code and models in multiple iterations. The process follows these steps: (1) model the system as an abstract state machine; (2) validate and verify the model; (3) generate test sequences automatically from the ASM model; (4) execute the tests over the implementation and compute the code coverage; (5) if the coverage is below the desired threshold, then refine the abstract state machine model to add the uncovered functionalities and return to step 2. We have applied the proposed approach in three case studies: a traffic light control system (TLCS), the IEEE 11073‐20601 personal health device (PHD) protocol, and the mechanical ventilator Milano (MVM). By applying RATE, at each refinement level, we have increased code coverage and identified some faults or conformance errors for all the case studies. The fault detection capability of RATE has also been confirmed by mutation analysis, in which we have highlighted that, many mutants can be killed even by the most abstract models.
Synergistic effects of agonists and two-pore-domain potassium channels on secretory responses of human pancreatic duct cells Capan-1
Authors: Sørensen Christiane E. , Trauzold Anna , Christensen Nynne M. , Tawfik Doaa , Szczepanowski Monika , Novak Ivana 
Published: December 2022

Abstract
Mechanisms of synergistic agonist stimulation and modulation of the electrochemical driving force for anion secretion are still not fully explored in human pancreatic duct epithelial cells. The first objective of this study was therefore to test whether combined agonist stimulation augments anion transport responses in the Capan-1 monolayer model of human pancreatic duct epithelium. The second objective was to test the influence of H+,K+-ATPase inhibition on anion transport in Capan-1 monolayers. The third objective was to analyze the expression and function of K+ channels in Capan-1, which could support anion secretion and cooperate with H+,K+-ATPases in pH and potassium homeostasis. The human pancreatic adenocarcinoma cell line Capan-1 was cultured conventionally or as polarized monolayers that were analyzed by Ussing chamber electrophysiological recordings. Single-cell intracellular calcium was assayed with Fura-2. mRNA isolated from Capan-1 was analyzed by use of the nCounter assay or RT-PCR. Protein expression was assessed by immunofluorescence and western blot analyses. Combined stimulation with different physiological agonists enhanced anion transport responses compared to single agonist stimulation. The responsiveness of Capan-1 cells to histamine was also revealed in these experiments. The H+,K+-ATPase inhibitor omeprazole reduced carbachol- and riluzole-induced anion transport responses. Transcript analyses revealed abundant TASK-2, TWIK-1, TWIK-2, TASK-5, KCa3.1, and KCNQ1 mRNA expression. KCNE1 mRNA and TREK-1, TREK-2, TASK-2, and KCNQ1 protein expression were also shown. This study shows that the Capan-1 model recapitulates key physiological aspects of a bicarbonate-secreting epithelium and constitutes a valuable model for functional studies on human pancreatic duct epithelium.
An Identity Theorem for the Fourier–Laplace Transform of Polytopes on Nonzero Complex Multiples of Rationally Parameterizable Hypersurfaces
Authors: Engel Konrad 
Published: December 2022

AbstractA set $$\mathcal {S}$$
S
of points in $$\mathbb {R}^n$$

R

n

is called a rationally parameterizable hypersurface if there is vector function $$\varvec{\sigma }:\mathbb {R}^{n-1}\rightarrow \mathbb {R}^n$$

σ

:

R

n
-
1

→

R

n

having as components rational functions defined on some common domain D such that $$\mathcal {S}=\{\varvec{\sigma }(\textbf{t}):\textbf{t}\in D\}$$

S
=
{

σ

(
t
)
:
t
∈
D
}

. A generalized n-dimensional polytope in $$\mathbb {R}^n$$

R

n

is a union of a finite number of convex n-dimensional polytopes in $$\mathbb {R}^n$$

R

n

. The Fourier–Laplace transform of such a generalized polytope $$\mathcal {P}$$
P
in $$\mathbb {R}^n$$

R

n

is defined by $$F_{\mathcal {P}}(\textbf{z})=\int _{\mathcal {P}}e^{\textbf{z}\cdot \textbf{x}}\,\textbf{dx}$$

F
P

(
z
)

=

∫
P

e

z
·
x

dx

. Let $$\gamma $$
γ
be a fixed nonzero complex number. We prove that $$F_{\mathcal {P}_1}(\gamma \varvec{\sigma }(\textbf{t}))=F_{\mathcal {P}_2}(\gamma \varvec{\sigma }(\textbf{t}))$$

F

P
1

(
γ

σ

(
t
)

)

=

F

P
2

(
γ

σ

(
t
)

)

for all $$\textbf{t} \in O$$

t
∈
O

implies $$\mathcal {P}_1=\mathcal {P}_2$$

P
1

=

P
2

if O is an open subset of D satisfying some well-defined conditions and we present similar results for the null set of the Fourier–Laplace transform of $$\mathcal {P}$$
P
. Moreover we show that this theorem can be applied to quadric hypersurfaces that do not contain a line, but at least two points, i.e., in particular to spheres.
Therapeutic education and physical activity are feasible and safe in hematologic cancer patients referred to chemotherapy: results of a randomized controlled trial
Authors: Accogli Monia Allisen , Denti Monica , Costi Stefania , Fugazzaro Stefania 
Published: December 2022

Abstract
Purpose
Although over 60% of patients with hematologic cancer report distressing fatigue, they often do not receive recommendations on fatigue management strategies. The aim of this pilot study was to estimate the feasibility of therapeutic education and physical activity (TEPA) by measuring the patients’ adherence to this multidimensional intervention. The secondary aim was to estimate the impact of TEPA on clinical outcomes.

Methods
Patients with hematologic cancer participated in this single-center, open-label, randomized controlled trial. The control group (CG) received two educational group sessions on fatigue and physical activity. The experimental group (EG) received the two educational sessions plus six weekly individual sessions aimed at implementing a personalized physical exercise program. Follow-ups were at 1, 3, and 7 months.

Results
Forty-six patients referred to chemotherapy were included, corresponding to 54% of recruitment rate. Adherence reached 90% in the EG and 68% in the CG. Most patients (65% in EG and 64% in CG) attended a minimum of 80% of the planned sessions. Overall retention rate was 87% (85% in EG and 91% in CG). No adverse events were registered. No between-group differences were detected in fatigue (FACIT-F), psychological distress (NCCN Distress Thermometer), QoL (EORTC QLQ-C30), or functional exercise capacity (TUG test and 6MWT). Adherence to an active lifestyle, measured by a semi-structured interview, increased from 56.5 to 84% in the EG at 7 months (p = 0.02), whereas it decreased slightly in the CG (from 47.8 to 42.9%).

Conclusion
Multidimensional rehabilitation interventions are feasible and safe in this population, and larger trials should focus on the efficacy of such approaches on clinically relevant outcomes.

Trial registration
ClinicalTrials.gov Identifier: NCT03403075.
Morpho-functional analysis of patient-derived xenografts reveals differential impact of gastric cancer and chemotherapy on the tumor ecosystem, affecting immune check point, metabolism, and sarcopenia
Authors: Venkatasamy A. , Guerin E. , Reichardt W. , Devignot V. , Chenard M. P. , Miguet L. , Romain B. , Jung A. C. , Gross I. , Gaiddon C. , Mellitzer G. 
Published: December 2022

Abstract
Objectives
Gastric cancer (GC) is an aggressive disease due to late diagnosis resulting from the lack of easy diagnostic tools, resistances toward immunotherapy (due to low PD-L1 expression), or chemotherapies (due to p53 mutations), and comorbidity factors, notably muscle atrophy. To improve our understanding of this complex pathology, we established patient-derived xenograft (PDX) models and characterized the tumor ecosystem using a morpho-functional approach combining high-resolution imaging with molecular analyses, regarding the expression of relevant therapeutic biomarkers and the presence of muscle atrophy.

Materials and methods
GC tissues samples were implanted in nude mice. Established PDX, treated with cisplatin or not, were imaged by magnetic resonance imaging (MRI) and analyzed for the expression of relevant biomarkers (p53, PD-L1, PD-1, HER-2, CDX2, CAIX, CD31, a-SAM) and by transcriptomics.

Results
Three well-differentiated, one moderately and one poorly differentiated adenocarcinomas were established. All retained the architectural and histological features of their primary tumors. MRI allowed in-real-time evaluation of differences between PDX, in terms of substructure, post-therapeutic changes, and muscle atrophy. Immunohistochemistry showed differential expression of p53, HER-2, CDX2, a-SAM, PD-L1, PD-1, CAIX, and CD31 between models and upon cisplatin treatment. Transcriptomics revealed treatment-induced hypoxia and metabolic reprograming in the tumor microenvironment.

Conclusion
Our PDX models are representative for the heterogeneity and complexity of human tumors, with differences in structure, histology, muscle atrophy, and the different biomarkers making them valuable for the analyses of the impact of platinum drugs or new therapies on the tumor and its microenvironment.