bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet-Mediated Transfer of Cardioprotection by Remote Ischemic Conditioning and Its Abrogation by Aspirin But Not by Ticagrelor
Authors: Lieder Helmut Raphael , Tsoumani Maria , Andreadou Ioanna , Schrör Karsten , Heusch Gerd , Kleinbongard Petra 
Published: May 2022

Abstract
Purpose
The role of platelets during myocardial ischemia/reperfusion (I/R) is ambivalent. They contribute to injury but also to cardioprotection. Repeated blood flow restriction and reperfusion in a tissue/organ remote from the heart (remote ischemic conditioning, RIC) reduce myocardial I/R injury and attenuate platelet activation. Whether or not platelets mediate RIC’s cardioprotective signal is currently unclear.

Methods and Results
Venous blood from healthy volunteers (without or with pretreatment of 500/1000 mg aspirin or 180 mg ticagrelor orally, 2–3 h before the study, n = 18 each) was collected before and after RIC (3 × 5 min blood pressure cuff inflation at 200 mmHg on the left upper arm/5 min deflation). Washed platelets were isolated. Platelet-poor plasma was used to prepare plasma-dialysates. Platelets (25 × 103/µL) or plasma-dialysates (1:10) prepared before and after RIC from untreated versus aspirin- or ticagrelor-pretreated volunteers, respectively, were infused into isolated buffer-perfused rat hearts. Hearts were subjected to global 30 min/120 min I/R. Infarct size was stained. Infarct size was less with infusion of platelets/plasma-dialysate after RIC (18 ± 7%/23 ± 9% of ventricular mass) than with platelets/plasma-dialysate before RIC (34 ± 7%/33 ± 8%). Aspirin pretreatment abrogated the transfer of RIC’s cardioprotection by platelets (after/before RIC, 34 ± 7%/33 ± 7%) but only attenuated that by plasma-dialysate (after/before RIC, 26 ± 8%/32 ± 5%). Ticagrelor pretreatment induced an in vivo formation of cardioprotective factor(s) per se (platelets/plasma-dialysate before RIC, 26 ± 7%/26 ± 7%) but did not impact on RIC’s cardioprotection by platelets/plasma-dialysate (20 ± 7%/21 ± 5%).

Conclusion
Platelets serve as carriers for RIC’s cardioprotective signal through an aspirin-sensitive and thus cyclooxygenase-dependent mechanism. The P2Y12 inhibitor ticagrelor per se induces a humoral cardioprotective signal.

Graphical abstract
Political leaders with professional background in business and climate outcomes
Authors: Diaz-Serrano Luis , Kallis Giorgos 
Published: May 2022

AbstractThe literature on how the ideology of political parties in power correlates with climate policy outcomes is abundant, but there is no similar literature for the individual characteristics of government leaders. This assessment is the first study of its kind, building on a dataset of government leaders of OECD countries for the period 1992–2017. We find that national presidents or prime ministers with a professional background in business are strongly correlated with bad climate mitigation outcomes. In particular, higher emissions and lower renewable energy deployment are more likely to occur during the tenure of former business people. Our results suggest that voters and pressure groups should pay attention to candidates’ professional backgrounds, in addition to their party’s ideology.
A Systematic Meta-analysis of the Reliability and Validity of Subjective Cognitive Load Questionnaires in Experimental Multimedia Learning Research
Authors: Krieglstein Felix , Beege Maik , Rey Günter Daniel , Ginns Paul , Krell Moritz , Schneider Sascha 
Published: May 2022

Abstract
For more than three decades, cognitive load theory has been addressing learning from a cognitive perspective. Based on this instructional theory, design recommendations and principles have been derived to manage the load on working memory while learning. The increasing attention paid to cognitive load theory in educational science quickly culminated in the need to measure its types of cognitive load — intrinsic, extraneous, and germane cognitive load which additively contribute to the overall load. In this meta-analysis, four frequently used cognitive load questionnaires were examined concerning their reliability (internal consistency) and validity (construct validity and criterion validity). Results revealed that the internal consistency of the subjective cognitive load questionnaires can be considered satisfactory across all four questionnaires. Moreover, moderator analyses showed that reliability estimates of the cognitive load questionnaires did not differ between educational settings, domains of the instructional materials, presentation modes, or number of scale points. Correlations among the cognitive load types partially contradict theory-based assumptions, whereas correlations with learning-related variables support assumptions derived from cognitive load theory. In particular, results seem to support the three-factor model consisting of intrinsic cognitive load, extraneous cognitive load, and germane cognitive load. Results are discussed in relation to current trends in cognitive load theory and recommendations for the future use of cognitive load questionnaires in experimental research are suggested.
Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking
Authors: Petrovic Dusan , Bodinier Barbara , Dagnino Sonia , Whitaker Matthew , Karimi Maryam , Campanella Gianluca , Haugdahl Nøst Therese , Polidoro Silvia , Palli Domenico , Krogh Vittorio , Tumino Rosario , Sacerdote Carlotta , Panico Salvatore , Lund Eiliv , Dugué Pierre-Antoine , Giles Graham G. , Severi Gianluca , Southey Melissa , Vineis Paolo , Stringhini Silvia , Bochud Murielle , Sandanger Torkjel M. , Vermeulen Roel C. H. , Guida Florence , Chadeau-Hyam Marc 
Published: May 2022

AbstractSmoking-related epigenetic changes have been linked to lung cancer, but the contribution of epigenetic alterations unrelated to smoking remains unclear. We sought for a sparse set of CpG sites predicting lung cancer and explored the role of smoking in these associations. We analysed CpGs in relation to lung cancer in participants from two nested case–control studies, using (LASSO)-penalised regression. We accounted for the effects of smoking using known smoking-related CpGs, and through conditional-independence network. We identified 29 CpGs (8 smoking-related, 21 smoking-unrelated) associated with lung cancer. Models additionally adjusted for Comprehensive Smoking Index-(CSI) selected 1 smoking-related and 49 smoking-unrelated CpGs. Selected CpGs yielded excellent discriminatory performances, outperforming information provided by CSI only. Of the 8 selected smoking-related CpGs, two captured lung cancer-relevant effects of smoking that were missed by CSI. Further, the 50 CpGs identified in the CSI-adjusted model complementarily explained lung cancer risk. These markers may provide further insight into lung cancer carcinogenesis and help improving early identification of high-risk patients.
Comparison of drone and vessel-based collection of microbiological water samples in marine environments
Authors: Horricks Ryan A. , Bannister Cody , Lewis-McCrea Leah M. , Hicks James , Watson Kiersten , Reid Gregor K. 
Published: May 2022

AbstractMany water quality metrics cannot be measured in situ and require collection of a physical sample for laboratory analysis. This includes microbiological samples for detection of fecal coliform bacteria in marine and freshwater systems which are a critical component of food safety programs for human consumption of bivalve shellfish worldwide. Water sample collection programs are typically vessel-based which can be time and resource intensive. In Canada, the Canadian Shellfish Sanitation Program aims to avoid consumption of contaminated molluscan bivalves by monitoring fecal coliform bacteria through vessel-based water sample collection. Uncrewed aerial vehicles or drones are becoming more commonly used for water sample collection given their relatively low cost but are rarely used to support microbiological analyses. A prerequisite for the acceptance of a new collection method for a regulatory program is to determine if the method of sample collection affects results. To assess this potential, we designed, developed, and tested a sampling device attached to the underside of a drone to collect water samples for bacteriological analysis. Drone and vessel-based samples were collected in the same location, at the same 20-cm depth, within a minute apart, at ten different geographic locations in coastal Nova Scotia waters to compare fecal coliform counts. Bacterial count estimates obtained from drone-collected samples were not significantly different than estimates obtained from vessel-collected samples (p < 0.5). Results from this study suggest novel water sampling techniques using drones could supplement or replace traditional vessel-based sampling methods.
Transitivity and homogeneity of orthosets and inner-product spaces over subfields of $${{\mathbb {R}}}$$
Authors: Vetterlein Thomas 
Published: May 2022

AbstractAn orthoset (also called an orthogonality space) is a set X equipped with a symmetric and irreflexive binary relation $$\perp $$
⊥
, called the orthogonality relation. In quantum physics, orthosets play an elementary role. In particular, a Hilbert space gives rise to an orthoset in a canonical way and can be reconstructed from it. We investigate in this paper the question to which extent real Hilbert spaces can be characterised as orthosets possessing suitable types of symmetries. We establish that orthosets fulfilling a transitivity as well as a certain homogeneity property arise from (anisotropic) Hermitian spaces. Moreover, restricting considerations to divisible automorphisms, we narrow down the possibilities to positive definite quadratic spaces over an ordered field. We eventually show that, under the additional requirement that the action of these automorphisms is quasiprimitive, the scalar field embeds into $${{\mathbb {R}}}$$
R
.
Autism Spectrum Disorder and Gender Dysphoria/Incongruence. A systematic Literature Review and Meta-Analysis
Authors: Kallitsounaki Aimilia , Williams David M. 
Published: May 2022

AbstractThe suggested overlap between autism spectrum disorder (ASD) and gender dysphoria/incongruence (GD/GI) has been much disputed. This review showed a relationship between ASD traits and GD feelings in the general population and a high prevalence of GD/GI in ASD. Our meta-analyses revealed that the pooled estimate of the prevalence of ASD diagnoses in GD/GI people was 11% (p < .001) and the overall effect size of the difference in ASD traits between GD/GI and control people was significant (g = 0.67, p < .001). Heterogeneity was high in both meta-analyses. We demonstrated that the chances that there is not a link between ASD and GD/GI are negligible, yet the size of it needs further investigation.
Shining a Light on a Hidden Population: Social Functioning and Mental Health in Women Reporting Autistic Traits But Lacking Diagnosis
Authors: Belcher Hannah L. , Morein-Zamir Sharon , Stagg Steven D. , Ford Ruth M. 
Published: May 2022

AbstractFemale Phenotype Theory (FPT) suggests that autistic women often present with less obvious social impairments than autistic men. We examined the possibility of an exaggerated female phenotype among undiagnosed but probably autistic women. In two nationwide online surveys, we compared self-reported social functioning and mental health between diagnosed autistic women and women without diagnosis who scored ≥ 32 on the Autism Quotient. Compared to diagnosed autistic women, probably autistic women had higher empathy and general social functioning, and were more likely to have received a diagnosis of Borderline Personality Disorder. Autistic women had typically received more mental health diagnoses prior to their ASC diagnosis than autistic men. These findings shed light on the history of misdiagnosis experienced by many autistic women.
Prediction of Neurodevelopmental Disorders Based on De Novo Coding Variation
Authors: Chow Julie C. , Hormozdiari Fereydoun 
Published: May 2022

AbstractThe early detection of neurodevelopmental disorders (NDDs) can significantly improve patient outcomes. The differential burden of non-synonymous de novo mutation among NDD cases and controls indicates that de novo coding variation can be used to identify a subset of samples that will likely display an NDD phenotype. Thus, we have developed an approach for the accurate prediction of NDDs with very low false positive rate (FPR) using de novo coding variation for a small subset of cases. We use a shallow neural network that integrates de novo likely gene-disruptive and missense variants, measures of gene constraint, and conservation information to predict a small subset of NDD cases at very low FPR and prioritizes NDD risk genes for future clinical study.
High-power short-duration ablation index–guided pulmonary vein isolation protocol using a single catheter
Authors: Badertscher Patrick , Knecht Sven , Spies Florian , Völlmin Gian , Schaer Beat , Schärli Nicolas , Bosshard Flurina , Osswald Stefan , Sticherling Christian , Kühne Michael 
Published: May 2022

Abstract
Background
Catheter ablation for atrial fibrillation (AF) is the most commonly performed electrophysiological procedure. To improve healthcare utilization, we aimed to compare the efficacy, efficiency, and safety of a minimalistic, streamlined single catheter ablation approach using a high-power short-duration ablation index–guided protocol (HPSD) vs. a control single-catheter protocol (SP).

Methods
Pulmonary vein isolation (PVI) with a single transseptal puncture without a multipolar mapping catheter was performed in 91 patients. Left atrial mapping was performed with the ablation catheter, only. Pacing maneuvers were used to confirm exit block. Procedural characteristics and success rates were compared using HPSD (n = 34) vs. a control (n = 57) ablation protocol. Freedom from recurrence was defined as a 1-year absence of AF episodes > 30 s, beyond the 3-month blanking period.

Results
Using the HPSD protocol the median procedure and RF ablation time were significantly shorter compared to the SP, 84 (IQR 76–100) vs. 118 min (IQR 104–141) and 1036 (898–1184) vs. 1949s (IQR 1693–2261), respectively, p < .001 for all. First-pass PVI was achieved using the HPSD protocol in 88% and using the SP in 87% of patients, p = 1.0. No procedural complications were observed. High-sensitivity cardiac troponin levels were significantly higher in patients using the HPSD protocol compared to the SP. At 12 months follow-up, 87% patients remained free from AF with no differences between groups.

Conclusions
A minimalistic, HPSD ablation index–guided PVI with a single-catheter approach is very efficient, safe, and associated with excellent clinical outcomes at 1 year.
Work-related support in clinical care for patients with a chronic disease: development of an intervention
Authors: Butink Maarten , Dona Desiree , Boonen Annelies , Peters Marlies , Baadjou Vera , Senden Theo , de Rijk Angelique 
Published: May 2022

Abstract
Background
Patients with a chronic disease are more vulnerable in the labor market, and work-related support in clinical care would enhance the timely support greatly needed in each phase of their working life. This paper describes the development of a generic stay-at-work intervention to provide work-related support in clinical care to patients with a chronic disease.

Methods
Steps 1–4 of Intervention Mapping (IM) were combined with action research principles. A needs assessment (Step 1) involved the project group formation, a literature review, qualitative studies with healthcare professionals (HCPs; n = 9) and patients (n = 10), consultation with financial staff and testing, and resulted in objectives (Step 2). Guided by methods and applications (Step 3), the intervention was developed, tested and finalized (Step 4).

Results
The needs assessment revealed the importance of behavioral change in HCPs, including changing attitude, self-efficacy, and social influence. For that purpose, a pathway and training sessions were developed. Testing these unveiled the need for practical tools and intervision. The final intervention comprises a care pathway as part of working routines, including screening, risk stratification, and tailored support. Practical tools, training sessions, and intervision for HCPs were developed.

Conclusions
Combining IM with action research principles resulted in a generic stay-at-work intervention in clinical care via behavioral change in HCPs. A generic care pathway, practical tools, training sessions, and intervision were developed. More specific alignment to specific patient groups is possible. To implement the intervention in another hospital, the local context, (financial) resources, and the national legislation should be considered.
How bricoleurs go international: a European cross-country study considering the moderating role of governmental entrepreneurship support programs
Authors: Kollmann Tobias , Hensellek Simon , Jung Philipp Benedikt , de Cruppe Katharina 
Published: May 2022

AbstractResearch increasingly suggests that innovativeness and internationalization are two intertwined pathways to growth for entrepreneurial ventures. However, both ways can be resource intensive and thus challenging. Therefore, theory points to the emerging concept of entrepreneurial bricolage to explain how resourceful behavior helps entrepreneurial ventures thrive despite facing the challenges associated with growth. At the same time, recent studies increasingly emphasize the importance of institutional support for successful venture growth. Combining both streams, this study explores product/service innovativeness as a mediator in the relationship between bricolage and the degree of internationalization and further investigates the moderating role of governmental entrepreneurship support programs in this relationship. By drawing on a unique dataset of 681 European entrepreneurial ventures, we find that bricolage is an important means for entrepreneurial ventures that target foreign markets, as it fosters product/service innovativeness and thereby enhances a venture’s degree of internationalization. Interestingly, governmental entrepreneurship support programs do not affect the link between bricolage and innovativeness, but they influence how innovativeness translates into greater degrees of internationalization. We discuss the theoretical and practical implications of our findings.
Parent-child Communication, Social Norms, and the Development of Cyber Aggression in Early Adolescence
Authors: Bullo Anna , Schulz Peter J. 
Published: May 2022

AbstractTo understand the development of cyber aggression during adolescence, it is important to consider the temporal variability of its potential predictors. This study uses a four-wave survey to investigate how changes in peer norms, parental norms, and parental communication are associated with two-year trajectories of online peer aggression. The sample includes 1521 Swiss middle school students (Mage T1 = 11.54, SD = 0.40; 48% female). The results showed that over time a better parental communication quality and anti-aggression norms predicted lower rates and slower development of cyber aggression. Moreover, parental variables emerged as a quite stable deterrent of aggressive conduct. Although entrance into adolescence is characterized by the rise of peer influence, results from this study suggest that parents maintain an important protective role.
A Person-Centered Approach to Adolescent Nonsuicidal Self-Injury: Predictors and Correlates in a Community Sample
Authors: Reinhardt Melinda , Rice Kenneth G. , Durán Barbara S. , Kökönyei Gyöngyi 
Published: May 2022

AbstractGrowing incidence of nonsuicidal self-injury (NSSI) and a lack of intensive examination of NSSI variability among adolescents justify identification of latent classes based on the endorsement of different NSSI behaviors. Latent class analysis was used to detect the heterogeneity of past month NSSI among 322 high school students (73.2% female). Two interpretable latent classes emerged. The Severe/Multimethod NSSI class (39%) engaged in almost all forms of NSSI with high intensity and motivated mainly for intrapersonal reasons. The results imply that compared to Mild/Moderate NSSI group (61%), the Severe class is at greater risk for poor mental health, which can exacerbate further NSSI acts. In school settings, identifying adolescents who are vulnerable for more severe NSSI can help to interrupt NSSI trajectories to emerging adulthood.
Effects of chlorine particle concentration on the human airway
Authors: Elwekeel Fifi N. M. , Cui Xinguang , Abdala Antar M. M. 
Published: May 2022

AbstractFor COVID-19, chlorine has lately been utilised as a home disinfectant. Given that chlorine is hazardous to the human airway, the current research investigates the effects of chlorine mass fraction and droplet size on the human airway. The effects are investigated at chlorine mass ratios of 2% (24 ppm), 10% (120 ppm), 15% (180 ppm), and 20% (240 ppm), as well as chlorine particle diameters of 10 nm, 20 nm, 30 nm, and 50 nm, and three inhalation rates (15 l/min, 30 l/min, and 60 l/min). The results reveal that when the chlorine mass fraction is 2% and the inhalation rate is low, the chlorine volume fraction decreases. Furthermore, at 2% chlorine and a rapid breathing rate, chlorine particles are accelerated to escape into the lungs.
Intranasal Oxytocin Attenuates Cognitive Impairment, β-Amyloid Burden and Tau Deposition in Female Rats with Alzheimer’s Disease: Interplay of ERK1/2/GSK3β/Caspase-3
Authors: El-Ganainy Samar O. , Soliman Omar A. , Ghazy Aya A. , Allam Maram , Elbahnasi Aya I. , Mansour Amira M. , Gowayed Mennatallah A. 
Published: May 2022

AbstractOxytocin is a neuropeptide hormone that plays an important role in social bonding and behavior. Recent studies indicate that oxytocin could be involved in the regulation of neurological disorders. However, its role in modulating cognition in Alzheimer’s disease (AD) has never been explored. Hence, the present study aims to investigate the potential of chronic intranasal oxytocin in halting memory impairment & AD pathology in aluminum chloride-induced AD in female rats. Morris water maze was used to assess cognitive dysfunction in two-time points throughout the treatment period. In addition, neuroprotective effects of oxytocin were examined by assessing hippocampal acetylcholinesterase activity, β-amyloid 1–42 protein, and Tau levels. In addition, ERK1/2, GSK3β, and caspase-3 levels were assessed as chief neurobiochemical mediators in AD. Hippocampi histopathological changes were also evaluated. These findings were compared to the standard drug galantamine alone and combined with oxytocin. Results showed that oxytocin restored cognitive functions and improved animals’ behavior in the Morris test. This was accompanied by a significant decline in acetylcholinesterase activity, 1–42 β-amyloid and Tau proteins levels. Hippocampal ERK1/2 and GSK3β were also reduced, exceeding galantamine effects, thus attenuating AD pathological hallmarks formation. Determination of caspase-3 revealed low cytoplasmic positivity, indicating the ceasing of neuronal death. Histopathological examination confirmed these findings, showing restored hippocampal cells structure. Combined galantamine and oxytocin treatment showed even better biochemical and histopathological profiles. It can be thus concluded that oxytocin possesses promising neuroprotective potential in AD mediated via restoring cognition and suppressing β-amyloid, Tau accumulation, and neuronal death.