bluuebunny/crossref_metadata_2025_split huggingface dataset:
The European framework for cybersecurity: strong assets, intricate history
Authors: Salvaggio Salvino A. , González Nahuel 
Published: November 2022

AbstractOver the last decade, the European Union (EU) has demonstrated a consistent determination to promote a global, open, stable, and secure cyberspace for everyone. A structured (and chronological) review of key EU documents, reports, and directives on cybersecurity shows that the recommendations from the relevant EU institutions (Parliament, Commission, Council) have been persistent over time, reiterating the same core issues that seem to not yet have been solved after a decade of debates and experts’ advice. Since at least 2012, EU institutions have identified the two domains that are under constant critical observation for the deployment of a coordinated European cybersecurity approach—gaps in policies and poor integration—while the European fundamentals of cybersecurity (both human and physical) have been consistently seen as an asset rather than a liability. However, the progressive de-professionalization of coding that tends to blur the distinction between amateurs and professionals should not be underestimated, as it furtively introduces a new class of risk related to unverified or circularly certified skills. It is therefore recommended that the regulatory framework is expanded to better govern the accreditation/certification of professional cybersecurity experts as well.
The environmental impact of health care for musculoskeletal conditions: A scoping review
Authors: McKenzie Bayden J. , Haas Romi , Ferreira Giovanni E. , Maher Chris G. , Buchbinder Rachelle 
Published: November 2022

BackgroundHealth care has significant environmental impact. We performed a scoping review to map what is known about the environmental impact of health care for musculoskeletal conditions.MethodsWe included published papers of any design that measured or discussed environmental impact of health care or health support services for any musculoskeletal condition in terms of climate change or global warming (e.g., greenhouse gas emissions it produces). We searched MEDLINE and Embase from inception to 2 May 2022 using keywords for environmental health and musculoskeletal conditions, and performed keyword searches using Google and Google Scholar. Two independent reviewers screened studies. One author independently charted data, verified by a second author. A narrative synthesis was performed.ResultsOf 12,302 publications screened and 73 identified from other searches, 122 full-text articles were assessed for eligibility, and 49 were included (published 1994 to 2022). Of 24 original research studies, 11 measured environmental impact relating to climate change in orthopaedics (n = 10), and medical aids for the knee (n = 1), one measured energy expenditure of laminar versus turbulent airflow ventilation systems in operating rooms during simulated hip replacements and 12 measured waste associated with orthopaedic surgery but did not relate waste to greenhouse gas emissions or environmental effects. Twenty-one editorials described a need to reduce environmental impact of orthopaedic surgery (n = 9), physiotherapy (n = 9), podiatry (n = 2) or occupational therapy (n = 1). Four narrative reviews discussed sustainability relating to hand surgery (n = 2), orthopaedic surgery (n = 1) and orthopaedic implants (n = 1).ConclusionDespite an established link between health care and greenhouse gas emissions we found limited empirical data estimating the impact of musculoskeletal health care on the environment. These data are needed to determine whether actions to lower the carbon footprint of musculoskeletal health care should be a priority and to identify those aspects of care that should be prioritised.
Potential Theory on Gromov Hyperbolic Spaces
Authors: Kemper Matthias , Lohkamp Joachim 
Published: November 2022

Abstract
Gromov hyperbolic spaces have become an essential concept in geometry, topology and group theory. Herewe extend Ancona’s potential theory on Gromov hyperbolic manifolds and graphs of bounded geometry to a large class of Schrödinger operators on Gromov hyperbolic metric measure spaces, unifying these settings in a common framework ready for applications to singular spaces such as RCD spaces or minimal hypersurfaces. Results include boundary Harnack inequalities and a complete classification of positive harmonic functions in terms of the Martin boundary which is identified with the geometric Gromov boundary.
Biological therapies in the prevention of maternal mortality
Authors: Ljubić Aleksandar , Bozanovic Tatjana , Piperski Vesna , Đurić Emilija , Begovic Aleksa , Sikiraš Marina , Perovic Andjela , Vukovic Jovana , Abazović Džihan 
Published: November 2022

Abstract
Although the maternal mortality rate has decreased and significant improvements have been made in maternal care, maternal death remains one of the substantial problems of our society. The leading causes of maternal death are postpartum hemorrhage, the most important cause of death in developing countries, and preeclampsia and venous thromboembolism, which are more prevalent in developed countries. To treat these conditions, a variety of therapeutic approaches, including pharmacologic agents and surgical techniques, have been adopted. However, a certain number of pregnant women do not respond to any of these options. That is the main reason for developing new therapeutic approaches. Biological medications are isolated from natural sources or produced by biotechnology methods. Heparin is already successfully used in the therapy of deep venous thrombosis and pulmonary embolism. Blood derivatives, used in an autologous or allogenic manner, have proven to be efficacious in achieving hemostasis in postpartum hemorrhage. Mesenchymal stem cells, alpha-1-microglobulin, and antithrombin exhibit promising results in the treatment of preeclampsia in experimental models. However, it is essential to evaluate these novel approaches’ efficacy and safety profile throughout clinical trials before they can become a standard part of patient care.
Effect of nano graphene and CNT addition on coating properties in friction surfacing process
Authors: Erdem Serkan 
Published: November 2022

Abstract
In this study, the wear behaviour of the composite material obtained as a result of the coating process by adding nano-size powder to the consumable rod with the friction surfacing method was investigated. An amount of 3–5 wt% nano graphene and carbon nano tube (CNT) were added into the hole drilled at a certain depth in the center of the consumable rod, and then the rod was subjected to sintering process. The obtained consumable rod was deposited on the substrate material at a certain rotational speed, horizontal and vertical progression speeds by friction surfacing method. Wear tests were carried out by subjecting the deposited surface samples to the pin-on-disc wear test. According to the results obtained, the increase in the additive ratio decreased the wear rate by approximately 30% in the 3 wt% graphene additive sample and 75% in the 5 wt% additive sample for 900 m wear distance. The same CNT additive ratios decreased the wear rate in the sample by 41% and 58%, respectively.
Die Theorie-Praxis-Differenz überwinden? Zur Mitwirkung von (Sport-) WissenschaftlerInnen in Wahlämtern herausgehobener Sportverbände
Authors: Lindt Katrin , Post Carina , Thieme Lutz 
Published: November 2022

Zusammenfassung
Die Überwindung von Theorie-Praxis-Differenzen wird entlang der Unterscheidung zwischen wissenschaftlicher Rigorosität und Relevanz geführt. Der direkte Übertrag von wissenschaftlichen Befunden in die Praxis könnte im Sport auch durch die Übernahme von Führungspositionen gelingen. Forschungen, in welchem Maße und warum WissenschaftlerInnen Führungspositionen im Sport parallel zu einer Position an der Hochschule begleiten, liegen bislang noch nicht vor. Die Ergebnisse zeigen, dass nur ein geringer Teil der Vorstandsämter in DOSB/DSB, Landessportbünden und olympischen Spitzenverbänden durch forschende WissenschaftlerInnen besetzt ist und diese bei Amtsübernahme und -ausübung nicht die Lösung der Theorie-Praxis-Differenz priorisieren.
TRAPPC1 is essential for the maintenance and differentiation of common myeloid progenitors in mice
Authors: Xu Yanan , Zhang Zhaoqi , Zhao Yang , Zhao Chenxu , Shi Mingpu , Dong Xue , Zhang Jiayu , Tan Liang , Zhang Lianfeng , Zhao Yong 
Published: November 2022

AbstractMyeloid cell development in bone marrow is essential for the maintenance of peripheral immune homeostasis. However, the role of intracellular protein trafficking pathways during myeloid cell differentiation is currently unknown. By mining bioinformatics data, we identify trafficking protein particle complex subunit 1 (TRAPPC1) as continuously upregulated during myeloid cell development. Using inducible ER‐TRAPPC1 knockout mice and bone marrow chimeric mouse models, we demonstrate that TRAPPC1 deficiency causes severe monocyte and neutrophil defects, accompanied by a selective decrease in common myeloid progenitors (CMPs) and subsequent cell subsets in bone marrow. TRAPPC1‐deleted CMPs differentiate poorly into monocytes and neutrophils in vivo and in vitro, in addition to exhibiting enhanced endoplasmic reticulum stress and apoptosis via a Ca2+‐mitochondria‐dependent pathway. Cell cycle arrest and senescence of TRAPPC1‐deleted CMPs are mediated by the activation of pancreatic endoplasmic reticulum kinase and the upregulation of cyclin‐dependent kinase inhibitor p21. This study reveals the essential role of TRAPPC1 in the maintenance and differentiation of CMPs and highlights the significance of protein processing and trafficking processes in myeloid cell development.
Iris, Zephyros and Eros: A genealogy of winged beings and winds
Authors: Di Serio Chiara 
Published: November 2022

AbstractIn a lesser known mythological tradition Eros is the son of Iris and Zephyros. His mother, Iris, belongs to a lineage of winged beings who are connected to a pre-cosmic dimension that precedes the historical reality ruled and guaranteed by Zeus. His father, Zephyros, is a wind and also a winged being whose story is linked to the birth of other superhuman beings who contribute to the foundation of a reality not yet fully established. Equally, Eros is a primordial superhuman being, whose nature at a mythical level is that of preceding the foundation of the cosmos. The purpose of this work is to investigate – through the meanders of mythological heritage – which elements of the narratives referring to these characters are relevant to classical Greek culture.
THİACLOPRİD’İN İNSAN LENFOSİTLERİNDE DNA HASARINA ETKİSİ
Authors: TOĞAY Vehbi Atahan , AŞCI ÇELİK Dilek 
Published: November 2022

Amaç
Thiacloprid neonikotinoid sınıfı bir insektisittir ve DNA
hasarına etkisi hakkında yapılan çalışma sayısı oldukça
sınırlıdır. Bu araştırma ile Thiacloprid’in insan
lenfosit DNA’sı üzerindeki etkisinin farklı dozlar ve
farklı maruziyet süreleri için değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem
4 erkek ve 4 kadın gönüllünün her birinden 15 mL kan
alınmış ve çalışmada yer alan gruplar için tüm katılımcıların
kanları ayrı ayrı kullanılmıştır. Thiacloprid,
100, 300 ve 500 μM olmak üzere 3 farklı dozda ve her
bir doz için 1, 2 ve 4 saat olmak üzere 3 farklı zamanda
uygulanmıştır. Her inkübasyon saati için ayrı ayrı
oluşturulan internal pozitif ve negatif kontrol grupları
karşılaştırma için kullanılmıştır. DNA hasarının tespiti
için comet metodu kullanılmış ve kuyruk DNA yüzdesi
parametresi hasarın göstergesi olarak seçilmiştir.
Bulgular
Tüm Thiacloprid uygulamaları DNA hasarında artışa
sebep olmuştur. Ancak en düşük doz olan 100 μM
Thiacloprid ile inkübasyon uygulanan gruplar 7, 10 ve
13’de meydana gelen artış, internal kontrol gruplarına
kıyasla istatistiksel olarak anlamlı bulunmamıştır
(p>0,05). 300 veya 500 μM Thiacloprid ile 1, 2 veya
4 s inkübasyon uygulanan gruplar 8, 9, 11, 12, 14 ve
15’de, internal kontrol gruplarına kıyasla DNA hasarında
anlamlı artış görülmüştür (p
A model for possible crustal deformation prior to a coming large interplate earthquake in the Tokai district, central Japan
Authors: Kato Naoyuki , Hirasawa Tomowo 
Published: November 2022

Abstract
We perform numerical simulations of a seismic cycle by applying a laboratory-derived friction law to evaluate possible crustal deformations prior to the hypothesized Tokai earthquake, which is expected to occur in the near future along the Suruga trough, central Japan. The frictional force obeying a rate- and state-dependent friction law is assumed to act on the plate interface in a 2D model of the subduction zone. We test two versions of the friction law: the so-called slowness version and the slip version. We select model parameters on the basis of historical documents about past large earthquakes in the Tokai district and the present coupling state of the plate interface beneath the Tokai district estimated by GPS observations. Simulation results for both the slowness and the slip version are as follows: (1) The coupling region of the plate interface becomes narrower with time in the interseismic period. (2) The inland crust contracts at a nearly constant rate for most of the interseismic period. The contraction rate decreases or a change from contraction to extension takes place before the occurrence of a large interplate earthquake. (3) Significant abnormal crustal deformation precedes the earthquake, and maximum amplitudes about one day before the earthquake exceed the noise levels in the case of clear weather of borehole strainmeters installed in the Tokai district. (4) The spatiotemporal variation of aseismic sliding on the plate interface perturbs the regional stress field around the source volume of the coming earthquake, leading possibly to precursory seismic quiescence in the overriding plate and a change in focal mechanisms of small earthquakes in the subducting slab. The most significant difference in the results between the slowness version and the slip version of the friction law is that amplitudes of preslip and crustal deformation just before earthquakes are several times larger for the slowness version than for the slip version. Although some ambiguity remains in the present model mainly because of the incompleteness of the friction law and the deficiency of observational data constraining model parameters, the physical model can be improved through the comparison of predicted crustal deformation with observations. Continuous and concentrated observations of crustal deformation and seismic activity are thus important in the Tokai district to understand quantitatively the sliding process preceding a large interplate earthquake there.
Comparative safety and efficacy of tenecteplase and streptokinase in prosthetic valve thrombosis: An observation from Eastern India
Authors: Mishra Chandrakanta , Mishra Archana , Dash Manoj , Routray Satyanarayan 
Published: November 2022

Prosthetic valve thrombosis (PVT) is a life-threatening emergency. Thrombolytic therapy is emerging as a potential substitute. The objective of this study was to assess the safety and efficacy of Tenecteplase (TNK) in comparison to streptokinase (STK) in patients with PVT. In this prospective study, patients with PVT who were not subjected to the surgery underwent thrombolysis with TNK (TNK arm) or STK (STK arm). Efficacy and safety of both treatment arms were judged from clinical, echocardiographic (ECHO), and Cinefluoroscopic parameters. Treatment outcomes and complications were compared between the two arms.Between December 2017 and December 2019, a total of 41 cases of PVT were enrolled to receive either TNK (n=23) or STK (n=18). After thrombolysis, complete recovery was significant in the TNK arm (82.6% [19/23] vs. 44.4% [8/18], respectively; p=0.007) irrespective of the valve position. This trend was observed in both mitral PVT (85.7% vs. 46.6%, respectively; p=0.03) and aortic PVT (77.8% vs. 33.3%, respectively; p=0.151). No failure was seen in the TNK arm but failure was observed in 1/3cases in the STK arm. No major bleeding was observed with either treatment. Minor bleeding and systemic embolization were non-significant (P=0.514). There were no deaths in the TNK arm but two patients (11%) from the STK arm died.To our knowledge, this is the largest published comparative evidence indicating superior efficacy and equal safety of tenecteplase compared to streptokinase for the treatment of prosthetic valve thrombosis irrespective of valve position and NYHA class.
Prevalence of iron deficiency in simple febrile seizures in children at different age group in Maharashtra
Authors: Jagadale Sandeep  Bahusaheb 
Published: November 2022

Prevalence of iron deficiency anaemia and febrile convolutions was observed in children at different age groups. Hence haematological profile has to be correlated with simple seizures. 130 Iron deficiency children below 5 years were compared with same number of healthy children (controlled group). Blood examination included Hb% HCT, MCV, MCH, MCHS, RDW, PS. Serum Ferritin was ruled out and compared in both groups. The Haematological profile and serum Ferritin study was compared in both groups and p value was highly significant (p&#60;0.00) in all parameters. The result suggests that, Iron deficiency is the main root cause for febrile seizures in children below 5 years of age. This pragmatic study will help paediatrician to treat such patients efficiently to avoid morbidity and mortality.
Evaluation of culture, molecular assay (TB-PCR), GeneXpert system and histopathology for detection of genital tuberculosis
Authors: Das Subrata , Mahata Ritu , Gupta Amrita 
Published: November 2022

Female genital tuberculosis (FGTB) has a crucial role in many gynaecological complaint and delay in diagnosis can cause irreversible damages. The new diagnostic technique GeneXpert system is accurate and rapid test can make paradigm shift in FGTB treatment. The aim of the study to estimate efficacy of different tests i.e. AFB BACTEC culture, molecular assay (TB-PCR) and histopathology in comparison to GeneXpert system to detect FGTB. The prospective observational study was conducted in between January, 2018 and June, 2019. Randomly selected total 62 patients were put under all four diagnostic tests from endometrial sampling. The positivity of genital TB and efficacy of the tests were compared with test result of GeneXpert assay.In our study, out of 62 patients, most commonly 33.9% were each from age group of 21-30 and 31-40 years i.e. reproductive ages, 45.2% were overweight, primary infertility of 48.4% patients were predominant symptomatology. Overall positivity by GeneXpert test was 21% (3/62), histopathology 8.1% (5/62), AFB BACTEC culture 12.9% (8/62) and 24.2% (15/62%) by molecular assay (TB-PCR). On evaluating against our diagnostic tests, specificity of histopathology, AFB BACTEC Culture and TB-PCR was 97.96%, 95.92% and 75.51%. The diagnostic tests were analysed by Kappa measure agreement in comparison to GeneXpert assay. The histopathology and AFB BACTEC Culture showed fair and moderate agreement respectively, but on the contrary TB-PCR have not showed any agreement with GeneXpert assay.High degree of suspicion and battery of tests needed for diagnosis of genital TB. Rapid diagnosis by GeneXpert assay may play a crucial role in TB control programme. Female genital tuberculosis (FGTB) has a crucial role in many gynaecological complaint and delay in diagnosis can cause irreversible damages. The new diagnostic technique GeneXpert system is accurate and rapid test can make paradigm shift in FGTB treatment.
To estimate the prevailing Serotype of dengue virus and IgM antibody in suspected dengue fever cases
Authors: Sudha N , Selvi R 
Published: November 2022

Dengue virus infection a vector borne disease affecting more than 50 million people worldwide annually. It is distributed in tropical and subtropical regions of the world, abundant in urban and semi-urban areas. It is the disease that spreads by bite of Aedes aegypti and Aedes albopictus mosquitoes. The virus being a RNA virus belongs to Flaviviridae family. The four serotypes of Dengue virus are DENV-1, DENV-2, DENV-3, and DENV-4 which have distinct antigenicity complex.This study was conducted in Microbiology Department, Government Stanley Medical College, Chennai, during the period Jan 2018 to Dec 2018 with 120 blood samples from patients of suspected dengue fever. Samples were selected by stratified random sampling method into three strata and each strata consisting of 40 samples based on duration of fever. All the samples were subjected to procedure for both NS1 antigen and IgM antibodies.15 NS1 positives samples with duration of fever less than 5 days were serotyped by PCR. : A total of 18 cases had NS1 antigen, 26 cases had IgM antibodies and 27 cases had both. A combination of the two tests detected a total of 44 cases. The chance of detection of NS1antigen decreased with duration of fever and IgM antibodies increased with duration of fever. The serotyping detected were DENV1 and DENV3 NS1 antigen detection by ELISA is useful in early phase of infection. A combination of NS1 ELISA and IgM ELISA have high sensitivity depending upon the duration of illness. Detection of DENV1 and DENV3 by PCR procedure helps to know the presence of prevailing serotype in this particular region which would be a good guide to predict the recurrence of outbreak and for efficient prevention and management.
Drug induced secondary angle closure glaucoma- A case series
Authors: Balakrishnan Saranya , Anandan Amrutha Mahalakshmi , Arunachalasamy Chandrika 
Published: November 2022

: We report 3 cases with acute bilateral angle closure glaucoma following intake of oral chlorthalidone, mefenamic acid, topiramate. : Case series. : All patients developed bilateral acute onset painful defective vision with shallow anterior chamber, raised intraocular pressure. Gonioscopy revealed bilateral occludable angle and ultrasonogram B scan showed shallow choroidal detachment, suggestive of drug induced non pupillary block secondary angle closure glaucoma. All patients were managed by discontinuation of causative drug and started on topical antiglaucoma medication and cycloplegic drug. : we would like to bring this potentially sight threatening and reversible ophthalmic condition to general physician, which can be managed effectively by timely referral and intervention.
Regional carbon isotope curve and biotic events in the Silurian of the Western slope of the Subpolar Urals and Chernov Uplift
Authors: Beznosova Tatiana , Matveev V. 
Published: November 2022

We present a new regional event scale based on a generalized analysis of results of determination of event-stratigraphic boundaries of biotic events of various levels and 13C isotope anomalies in studied reference sections of the Subpolar Urals and the Chernov Uplift.
The combined regional curve of carbon isotopic composition allows finding out several isotopic events in the Silurian.