bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Extremely Fast Charging through Boosting Intercalative Redox Pseudocapacitance: A SbCrSe3 Anode for Large and Fast Sodium Storage
Authors: Peng Baixin , Xu Shumao , Lv Zhuoran , Zhang Shaoning , Gao Yusha , Lin Tianquan , Huang Fuqiang 
Published: November 2022

AbstractAlloying‐type metals with high theoretical capacity are promising anode materials for sodium ion batteries, but suffer from large volume expansion and sluggish reaction kinetics. Dispersing alloying‐type metal into a buffer matrix with interfacial anionic covalent bonding is an effective method to solve the above issues. Here, this bifunctional structural unit is designed by incorporating high‐capacity Sb metal into a rigid CrSe framework for fast‐charging applications. The high‐capacity and high‐rate sodium storage can be synergistically realized in the bifunctional SbCrSe system, where the rigid CrSe framework endows the SbCrSe3 anodes with superior structural stability and improved intercalative redox pseudocapacitance. Moreover, the volume expansion of Sb during discharge can be buffered by the CrSe chain‐like matrix. The novel SbCrSe3 anode delivers a high charge capacity of 472 mAh g−1 at a current density of 0.4 C and retains ≈100% capacity at 60 C over 10 000 cycles. Further in situ and ex situ characterization reveal the multistep reaction mechanism, and the breakage and formation of reversible SbSe bonds during (dis)charge. The proposed bifunctional structural unit that combines alloying type anodes and intercalative anodes is expected to pave a new road for the development of high capacity and high rate anode materials.
Electrochemical ammonia production from nitrates in agricultural tile drainage: Technoeconomic and global warming analysis
Authors: Samaroo Sharmila , Hickey David P. 
Published: November 2022

AbstractNitrates from agricultural wastewater are harmful to human health and result in eutrophication. Several emerging electrochemical technologies have been developed independently to enable efficient recovery and recycling of nitrate waste; however, it remains unclear whether the implementation of such combined technologies can be economically viable. Herein, we perform technoeconomic and global warming potential analyses on several hypothetical nitrate capture and conversion systems for the recovery of nitrates from agricultural wastewater and conversion of nitrate to ammonia. The energy efficient technologies incorporated include: electrodialysis for nitrate separation, electrocatalysis for ambient ammonia production, and agrophotovoltaics as a clean energy source. Our technoeconomic analysis reveals that despite advancements in nitrate separation and conversion, capital investments for system installation cannot be recovered by the financial benefit of on‐site fertilizer production. Our analysis highlights the necessity of government intervention to promote nitrate abatement technologies to ensure environmental compliance and protect public health.
MOF‐derived bimetallic NiCo nanoalloys for the hydrogenation of biomass‐derived levulinic acid to γ‐valerolactone
Authors: Xu Hong , Hu Di , Lin Lu , Zhang Man , Li Xin , Zeng Yongjian , Amer Mahmoud , Luo Wenhao , Yan Kai 
Published: November 2022

AbstractThe selective hydrogenation of biomass‐derived levulinic acid (LA) to γ‐valerolactone (GVL) is one of pivotal reactions in many of the biorefinery schemes for the production of value‐added chemicals and biofuels. Herein, we have fabricated carbon‐supported bimetallic NiCo catalysts based on the metal–organic framework (MOF) material via a pyrolysis method. The as‐obtained Ni1Co1 bimetallic catalyst outperforms monometallic counterparts in the catalytic performance of LA‐to‐GVL, with a nearly full conversion of LA and a GVL yield of 95.2%, in particular with an excellent catalyst stability up to seven consecutive runs at 160°C and 4 MPa H2. Based on a combined characterization study by employing advanced techniques, for example, extended x‐ray absorption fine structure (EXAFS), high‐angle annular dark‐field scanning transmission electron microscopy (HADDF‐STEM), and electron paramagnetic resonance (EPR), we reveal that the enhanced catalytic performance, in particular the excellent stability, could be attributed to the formation of the bimetallic alloys, which efficiently alleviates the metal leaching and sintering during catalysis.
Variants in AQP11 may result in autosomal recessive bilateral cystic renal dysgenesis
Authors: Price Michael E. , Fishler Kristen P. , Muff‐Luett Melissa , Mauch Teri J. , Brunelli Luca , Euteneuer Joshua C. 
Published: November 2022

AbstractCongenital renal cystic dysplasia is a rare disease that occurs in approximately 1 in 4000 children and is often discovered in the antenatal period by ultrasound. It is commonly associated with oligohydramnios in utero and/or renal insufficiency or failure in the postnatal period. Aquaporins are membrane proteins that serve as transport channels in the transfer of water or small solutes across cell membranes. They play a role in the development of renal cysts. Aquaporin 11 (AQP11) deficient mice develop polycystic kidney disease in utero due to disruption of polycystin‐1. Here we describe a case of bilateral cystic kidney disease in a patient with novel compound heterozygous variants in AQP11: c.780G>T (p. Trp260Cys) and c.472C>T (p.Pro158Ser) (NM_173039.2) identified by whole genome sequencing. These findings suggest, for the first time, the potential role of AQP11 in congenital renal cystic dysplasia.
Modular One‐Step Three‐Component Assembly of Isochromans via Palladium/Norbornene Cooperative Catalysis
Authors: Zhang Xinping , Wei Han , Wei Qiang , Wu Chenggui , Liu Chang , Cheng Hong‐Gang , Zhou Qianghui 
Published: November 2022

AbstractWe herein report a modular one‐step three‐component protocol for the assembly of isochromans, which involved a Catellani/oxa‐Michael addition cascade. This approach features readily available starting materials, mild reaction conditions, low palladium catalyst loading, good scalability as well as high step‐ and atom‐economy.
Persicamidine – Außergewöhnliche Sesquarterpenoide mit potenter antiviraler Bioaktivität gegen Coronaviren
Authors: Keller Lena , Oueis Emilia , Kaur Amninder , Safaei Nasim , Kirsch Susanne H. , Gunesch Antonia P. , Haid Sibylle , Rand Ulfert , Čičin‐Šain Luka , Fu Chengzhang , Wink Joachim , Pietschmann Thomas , Müller Rolf 
Published: November 2022

AbstractEine neue Substanzfamilie von ungewöhnlichen Sesquarterpenoiden (Persicamidine A–E) mit hoher antiviraler Aktivität wurde aus einem kürzlich entdeckten Aktinobakterien‐Stamm (Kibdelosporangium persicum sp. nov.) isoliert, welcher aus einem Wüstenhabitat im Iran stammt. Umfangreiche NMR‐Analysen entlarvten ein hexazyklisches Terpenoidmolekül mit einer modifizierten Zuckereinheit auf einer Seite und einer höchst ungewöhnlichen Isoharnstoffeinheit, die mit der Terpenoidstruktur verbunden ist. Die Strukturen der fünf Derivate unterschieden sich ausschließlich durch die Aminoalkyl‐Seitenkette, die an die Isoharnstoffeinheit gebunden ist. Die Persicamidine A–E zeigten eine starke Aktivität gegen hCoV‐229E‐ und SARS‐CoV‐2‐Viren im nanomolaren Bereich bei gleichzeitig sehr guten Selektivitätsindizes. Dies macht die Persicamidine zu vielversprechenden Ausgangsverbindungen für die Arzneimittelentwicklung.
Controlled Annealing in Adaptive Multicomponent Gels
Authors: Ravarino Paolo , Panja Santanu , Bianco Simona , Koev Todor , Wallace Matthew , Adams Dave J. 
Published: November 2022

AbstractWe use a pH‐driven annealing process to convert between co‐assembled and self‐sorted networks in multicomponent gels. The initially formed gels at low pH are co‐assembled, with the two components coexisting within the same self‐assembled structures. We use an enzymatic approach to increase the pH, resulting in a gel‐to‐sol transition, followed by a hydrolysis to lower the pH once again. As the pH decreases, a self‐sorted network is formed by a two‐stage gelation process determined by the pKaof each component. This approach can be expanded to layered systems to generate many varied systems by changing composition and rates of pH change, adapting their microstructure and so allowing access to a far greater range of morphologies and complexity than can be achieved in single component systems.
Emerging Materials for Interfacial Solar‐Driven Water Purification
Authors: Cao Sijia , Thomas Arne , Li Changxia 
Published: November 2022

AbstractSolar‐driven water purification is considered as an effective and sustainable technology for water treatment using green solar energy. One major goal for practical applications is to improve the solar evaporation performance by the design of novel photothermal materials, with optimized heat localization and water transport pathways to achieve reduced energy consumption for water vaporization. Recently, some emerging materials like polymers, metal‐organic frameworks (MOFs), covalent organic frameworks (COFs) and also single molecules were employed to construct novel solar evaporation systems. In this minireview, we present an overview of the recent efforts on materials development for water purification systems. The state‐of‐the‐art applications of these emerging materials for solar‐driven water treatment, including desalination, wastewater purification, sterilization and energy production, are also summarized.
Bulk‐like Pt(100)‐oriented Ultrathin Surface: Combining the Merits of Single Crystals and Nanoparticles to Boost Oxygen Reduction Reaction
Authors: Gong Shuyan , Sun Mingze , Lee Yiyang , Becknell Nigel , Zhang Jiangwei , Wang Zhongqi , Zhang Liang , Niu Zhiqiang 
Published: November 2022

AbstractSingle crystal surfaces with highly coordinated sites very often hold high specific activities toward oxygen reduction reaction (ORR) and others. Transposing their high specific activity to practical high‐surface‐area electrocatalysts remains challenging. Here, ultrathin Pt(100) alloy surface is constructed via epitaxial growth. The surface shows 3.1–6.9 % compressive strain and bulk‐like characteristics as demonstrated by site‐probe reactions and different spectroscopies. Its ORR activity exceeds that of bulk Pt3Ni(100) and Pt(111) and presents a 19‐fold increase in specific activity and a 13‐fold increase in mass activity relative to commercial Pt/C. Moreover, the electrochemically active surface area (ECSA) is increased by 4‐fold compared to traditional thin films (e.g. NSTF), which makes the catalyst more tolerant to voltage loss at high current densities under fuel cell operation. This work broadens the family of extended surface catalysts and highlights the knowledge‐driven approach in the development of advanced electrocatalysts.
Nanofabrication of hybrid nanomaterials: Macroscopically aligned nanoparticles pattern via directed self‐assembly of block copolymers
Authors: Mendoza Cesar , Nirwan Viraj Pratap , Fahmi Amir 
Published: November 2022

AbstractPeriodic hybrid nanostructured materials based on aligned inorganic nanoparticles within self‐assembled copolymer matrixes aimed to harness the collective properties of generated functional nanomaterials. The nanoparticles are desirable for their useful magnetic, optical, catalytic, and electronic properties owed to the quantum confinement effect. For instance, gold, palladium and platinum as nanoparticles, have shown significant change in the physiochemical properties in comparison to their bulk materials. If the nanoparticles are aligned into well‐defined macroscopic periodic nanostructures in diverse of morphologies, the unique collective properties are significantly enhanced. These unique properties can be transformed to improve the performance of storage media, multi‐contact tracks solar panels and optoelectronic devices. Within this review, the nanofabrication tools will be presented as an alternative route to conventional top‐down methods for the fabrication of periodic nanostructured hybrid materials. A simple approach is reviewed to fabricate periodic nanostructured hybrid systems based on the directed assembly of inorganic nanoparticles into well‐defined periodic three‐dimensional nanostructures provided by the self‐assembling ability of block copolymers. The fabrications of varieties morphologies and the formation mechanism at different dimensions will be discussed as well as the characterization techniques. Finally, several applications of the proposed hybrid nanostructures are highlighted for the next generation of miniaturized devices.
Fluorine‐free, highly transparent, chemically durable and low ice adhesion icephobic coatings from biobased epoxy and polydimethylsiloxane
Authors: Wang Xiangzhao , Huang Xiaobin , Hu Wenbin , Ji Zemin , Sheng Haoqiang , Liu Hong 
Published: November 2022

AbstractPassive icephobic surfaces have been extensively studied by researchers due to their advantages of delaying icing time and reducing ice adhesion strength. However, icephobic materials with petroleum‐based resources and toxic fluorine‐containing chemicals, as one of the excellent icephobic materials, are very unfavorable for resource conservation and environmental protection. In this study, we report fluorine‐free, highly transparent, chemically durable and low ice adhesion icephobic coatings prepared by glycerol triglycidyl ether (GTE) derived from natural glycerin and bis(3‐aminopropyl) terminated polydimethylsiloxane (PDMS) via one‐pot method. On the one hand, PDMS with multiple methyl groups and two amine groups acts as a hydrophobic modifier to modulate the surface energy of the coatings, and also acts as a structure modifier to modulate the mechanical properties of the coatings, which allow us to design and synthesis the coating with excellent deicing performance (ice adhesion strength can reach about 16 kPa). On the other hand, GTE with multiple epoxy groups works as cross‐linker to endow the coatings with good cross‐linked networks, so that the coatings showed good durability after being subjected to different temperature treatment and different solution treatments. In additional, the transmittance of the coating is above 91.4%, which is expected to be applied to windows and sensors.
Redox Active cAAC−Fluorene/Indene Systems Displaying Solvatochromism, Green Luminescence and pH Sensing: Functionalization of Fluorenyl/Indenyl Rings with Radical Carbene
Authors: Arumugam Selvakumar , Bhattacharya Madhuri , Gorantla Sai Manoj N. V. T. , Mondal Kartik Chandra 
Published: November 2022

AbstractTwo new series of air stable compounds of cAACX = fluorene/indene (X = Me2, Et2, Cy) [cAAC = cyclic (alkyl) amino carbene] have been isolated and well characterized by X‐ray single crystal diffraction, photoluminescence, cyclic voltammogram (CV) and electron paramagnetic resonance (EPR) studies. Fluorescence studies reveals green light emission of cAAC bonded fluorene, whereas free fluorene generally displays a violet emission. Interestingly, the sterically crowded cAAC‐fluorene analogue display solvatochromism and CF3CO2H sensing in solution. CV of the these compounds show a quasi‐reversible electron transfer process, indicating the functionalization of fluorene/indene with radical anionic form of carbene, confirmed by CV/EPR measurements. DFT/TDDFT calculations and energy decomposition analysis coupled with natural orbital for chemical valence (EDA‐NOCV) have been carried out to study different aspects of bonding and electronic transitions. Such a class of redox active and thermally stable organic molecules may be suitable for molecule based spin memory devices in future.
Observer‐based adaptive output‐constrained control design of switched stochastic nonlinear systems with input saturation
Authors: Cao Zhongwen , Zhang Liang , Niu Ben , Zong Guangdeng , Zhao Xudong 
Published: November 2022

AbstractIn this article, the problem of adaptive fuzzy control for output‐constrained switched stochastic nonlinear systems subject to input saturation is addressed. By employing the trigonometric function mapping method, the constrained systems are transformed into unconstrained ones, and the control goals of the original constrained systems are not affected. Meanwhile, an auxiliary system is established to deal with the issue of input saturation, and an observer is constructed to estimate the unmeasured states. Then, the unknown nonlinear functions in the system are approximated by the fuzzy logic systems (FLSs). Based on the backstepping technique and Lyapunov function method, an output feedback control strategy is designed, where the dynamic surface control technique is applied in the backstepping design process to overcome the issue of a large number of online calculations. The designed controller can guarantee that all the signals of the system satisfy bounded conditions, and the output can track given reference signals within a small error range. Finally, a simulation example is given to verify the effectiveness of the proposed control scheme.
A simplified direct on‐chip forward or reverse immunoassay for evaluating protein–protein interactions in the serum
Authors: Liu Qian , Ye Lei , Li Song‐Guo , Gao Yi , Liu Sheng‐Sheng , Liu Biao , Li Xiao‐Xue , Du Wei‐Dong 
Published: November 2022

AbstractBackgroundThe identification of protein–protein interactions is a great challenge. In this study, we fabricated a gold surface‐modified biochip with activated sophorolipids (SLs) in combination with 16‐amino‐1‐hexadecanethiol hydrochloride to detect serum proteins.Main Methods and Major ResultsThe on‐chip immunoassay reported here included a forward assay, in which a ligand is immobilized on the biochip surface and allowed to interact with its free specific receptor in liquid phase, and a reverse assay, in which a receptor is loaded on the biochip surface and combined with its free specific ligand in solution. The specificity of the molecular interactions on the biochip was evaluated using immunological blocking assays and chemiluminescent immunoassays (CLIA). Hemophagocytic lymphohistiocytosis (HLH) serum was used to test the potential utilization of the biochip. Reverse receptor CD25‐based interleukin (IL)‐2 and forward ligand IL‐2‐based CD25 assays revealed that the limit of detection of the target proteins was as low as 156 and 78 pg/ml, respectively. Using receptor‐ or ligand‐based platforms, we found that the positive rates of free IL‐2 and soluble CD25 (sCD25) monomers in the sera of HLH patients were 14.3% and 71.4%, respectively. In addition, the biochip showed good compatibility with CLIA for the measurement of sCD25 (r = 0.77, p < 0.01).Conclusions and ImplicationsBiochip platforms, such as on‐chip immunoprecipitation (IP), can be used to evaluate the interactions between proteins, ligands, and receptors, or enzymes and substrates in serum.
Estimating recurrences prevented and costs avoided with atezolizumab in early non‐small cell lung cancer in the United States
Authors: Sharma Rishika , Ogale Sarika , Smith Nathaniel J. , Lee Janet Shin 
Published: November 2022

AbstractBackgroundRecurrence of early‐stage non‐small cell lung cancer (eNSCLC) is associated with significant mortality and costs. Atezolizumab (ATZ) was recently approved as adjuvant treatment following resection and platinum‐based chemotherapy for adults with stage II‐IIIA NSCLC with PD‐L1 expression ≥1% after demonstrating significant improvement in disease‐free survival (DFS) relative to best supportive care (BSC) in the IMpower010 trial (NCT02486718). This study evaluated the population‐level impact of ATZ as adjuvant treatment for eNSCLC in the United States by estimating the number and costs of recurrences avoided.MethodsA Monte Carlo simulation model estimated the cumulative number of recurrences and deaths prevented, along with direct, indirect, and terminal care costs, by treating eNSCLC patients with ATZ compared to BSC. The model included eligible patients treated in any given year and followed over a 5‐year period. Recurrence and mortality rates and costs were based on the IMpower010 data and supplemented by estimates from published literature.ResultsAn estimated 4400 eNSCLC patients in the United States were eligible for adjuvant ATZ in any given year, of whom 2387 would experience recurrence within 5 years with BSC. Following the introduction of ATZ, 1030 (95% confidence interval [CI]: 1023, 1036) recurrences and 369 (95% CI: 362, 376) deaths would be avoided with estimated reductions in cumulative recurrence‐related direct, indirect, and terminal care costs of $785 million, $15 million, and $32 million, respectively, over a 5‐year time horizon.ConclusionsAdjuvant ATZ is estimated to prevent a significant number of recurrences and reduce the economic burden of eNSCLC.
Design, Synthesis and Bio‐Evaluation of Novel Chalcones Bridged with 1,3,4‐Oxadiazole Linkers: ADMET and Docking Analysis
Authors: Gogisetti Gopalarao , Kanna Umamaheswararao , Sharma Vishal , Rao Allaka Tejeswara , Rao Tadiboina Bhaskara 
Published: November 2022

AbstractIn this article, we prepared a novel series of 1,3,4‐oxadiazoles containing chalcone analogs via replacement of phthalazine which had increased antibacterial activity and the final compounds were confirmed by proton, carbon nuclear magnetic resonance spectroscopy, infrared and mass spectral analysis. Two sets of 1,3,4‐oxadiazoles like 2‐methyl‐5‐substitutedbenzylthio‐1,3,4‐oxadiazolyl‐4‐methylphthalazine‐2‐ones (3a–f), (E)‐substituted phenyl acryloylphenyl‐4‐methyl‐1‐oxophthalazine‐1,3,4‐oxadiazolylthioacetamides (5a–f) were designed, synthesized and evaluated for their in vitro antibacterial potency against different Gram‐(+ve), Gram‐(–ve) microorganisms and fungal strains. The synthesized 4‐methyl‐2‐{[5‐({[2‐(trifluoromethyl)phenyl]methyl}sulfanyl)‐1,3,4‐oxadiazol‐2‐yl]methyl}phthalazin‐1(2H)‐one (3c), 4‐methyl‐2‐[(5‐{[(4‐nitrophenyl)methyl]sulfanyl}‐1,3,4‐oxadiazol‐2‐yl)methyl]phthalazin‐1(2H)‐one (3d), N‐(4‐{(2E)‐3‐[2‐(dimethylamino)phenyl]prop‐2‐enoyl}phenyl)‐2‐({5‐[(4‐methyl‐1‐oxophthalazin‐2(1H)‐yl)methyl]‐1,3,4‐oxadiazol‐2‐yl}sulfanyl)acetamide (5d), and N‐{4‐[(2E)‐3‐(3‐hydroxy‐4‐methoxyphenyl)prop‐2‐enoyl]phenyl}‐2‐({5‐[(4‐methyl‐1‐oxophthalazin‐2(1H)‐yl)methyl]‐1,3,4‐oxadiazol‐2‐yl}sulfanyl)acetamide (5e) displayed improved activity with MICs 1.41, 0.87, 2.16, 0.89 μg/mL as compared to the standard drugs rifamycin, ciprofloxacin, fluconazole (MIC=1.52, 1.94, 3.02 μg/mL). The prepared compounds were also analyzed with better target binding towards bacterial bioavailability, 5e exhibited highest bonds with amino acids ArgA45, LysA20, LysA17, ArgA171, AspA49, IleA14, HisA18 and having docking energy −8.68 Kcal/mol and dissociation constant 432.48 nM, respectively. These compounds were further evaluated for their ADMET and physicochemical properties by using SwissADME.
The strategic uses of collagen in adherent cell cultures
Authors: Chua PinFen , Lim William K. 
Published: November 2022

AbstractThe culture of adherent mammalian cells involves adhesion to the tissue culture vessel. This requires attachment factors from serum and/or a suitable substrate on the vessel surface. Some cells require collagen or other substrates to promote neurite outgrowth, differentiation or growth. However, laboratories often lack guidance on the selection and/or optimisation of collagen. We model such selection/optimisation work in the PC12 neuronal cell line. PC12 (NS‐1 variant) cells require a substrate for adherence. Comparing cell attachment against a series of substrates, we found collagen IV to be optimal. We show by comparison of morphology against a range of concentrations that 10 µg/ml is sufficient for supporting cell attachment, and also differentiation. PC12 cells from Riken Cell Bank do not require a substrate for routine culturing but only for differentiation. As all substrates supported attachment equally well, we used a novel serum‐free approach and identified collagen IV as its preferred substrate. For these cells, Dulbecco's modified eagle's medium but not Roswell Park Memorial Institute (RPMI) media supports normal cell attachment. However, coating with collagen IV enabled the cells to grow equally well in RPMI. Hence the strategic use of collagen is essential in laboratories working with anchorage‐dependent cell lines.