bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-neuropathic Pain Mechanistic Study on A. conyzoides Essential Oil,
Precocene II, Caryophyllene, or Longifolene as Single Agents and in
Combination with Pregabalin
Authors: Sukmawan Y. Purwandi , Anggadiredja Kusnandar , Adnyana I. Ketut 
Published: April 2022

Background:
Neuropathic pain has become a contributor to the global burden of illness.
However, the currently available drugs exhibit inadequate pain relief and significant side effects. Our
previous study demonstrated that the essential oil of Ageratum conyzoides exerts potent antineuropathic
pain activity through opioid receptor activation. Precocene II, longifolene, and caryophyllene
are the largest component of the A. conyzoides essential oil.

Objective:
The objective of the study was to determine the anti-neuropathic pain activity of precocene
II, longifolene, and caryophyllene as single agents and in combination with pregabalin. Possible
mechanisms of action involving the opioid receptor, ATP-sensitive potassium channel, and gammaaminobutyric
acid (GABA) were further investigated.

Methods:
The experimental animals (male mice Swiss Webster) were divided randomly into seven
groups, namely, Normal control (naïve mice), Negative control (CMC 1%), Sham (CMC 1%), Positive
control (Pregabalin 0,195 mg/ 20 g BW of mice), Test I (Precocene II 21.09 mg/Kg BW), Test II
(Longifolene 9.94 mg/Kg BW), and Test III (Caryophyllene 3.64 mg/Kg BW). Each group contained
3 animals. The test groups that demonstrated anti-neuropathic pain activity were further tested in combination
with pregabalin, followed by mechanistic studies. The negative, positive, and test I-III groups
were induced with chronic constriction injury.

Results:
The results of the study demonstrated that caryophyllene and longifolene, but not precocene
II, exerted anti-neuropathic pain activity. The caryophyllene was shown to involve in the activation of
opioid receptors and ATP-sensitive potassium channels. It was also reported to increase GABA concentration
in the spinal cord. We further found that longifolene exerted its action via opioid receptor
activation. The combination of A. conyzoides essential oil, longifolene, or caryophyllene with pregabalin
demonstrated additive anti-neuropathic pain activity.

Conclusion:
Taken together, the results of the present study suggested that the A. conyzoides essential
oil and caryophyllene have the potential to be developed as novel drugs to treat neuropathic pain.
Attitudes and Acceptance of the Palestinian Population Towards COVID-19 Health Precautions and Vaccinations: A Cross-Sectional Study
Authors: Hamdan Anas , Ghanim Mustafa , Mosleh Rami , Jarrar Yazun 
Published: April 2022

Background:
COVID-19 is a new pandemic and the best protection against this infection is by vaccination.

Aims:
To assess the commitment to COVID-19 health precautions and vaccination willingness among the Palestinian population.

Methods:
An online-based survey was developed in an observational cross-sectional study. A total of 1367 participants were recruited conveniently between February and June 2021. To carry out comparisons, Mann-Whitney or Kruskal–Wallis was used for numerical variables and chi-square or Fisher's exact for categorical. Multiple logistic regression was used for health precautions and multinomial logistic regression for vaccination willingness.

Results:
The commitment to the majority of health precautions was predicted by perceiving COVID-19 threat, educational level, and city residency (P < 0.05). Social distancing and sterilizer usage were associated with city residency (P < 0.001). Students, males, and unemployed participants were less committed to health precautions (P < 0.05). Vaccination willingness was less predicted by the perception of an ineffective vaccine (P < 0.001), perceiving no threat of COVID-19 (P < 0.05) or perception of threat for old/or chronic diseases (P < 0.05), employed participants (P < 0.05), without chronic diseases (P < 0.05), and not committed to wearing a mask (P < 0.001).

Conclusion:
COVID-19 threat perception, high education level, and city residency predict more commitment to health precautions, in contrast to male students and unemployed participants. On the other hand, Having no chronic diseases, perception of ineffective vaccines, unperceived COVID-19 threat, and unwillingness to wear masks predicted less vaccination acceptance. Therefore, it is critical to increase awareness about the COVID-19 threat, health precautions, and vaccination efficacy.
This study is cross-sectional. Future works concerning changes in Attitudes toward COVID-19 health precautions and vaccination should be encouraged including vaccinated participants.
Innovation for Sugarcane Planting Material in Ryland Farming
Authors: Ningsih Devita Areifvia , Taryono Taryono , Wulandari Rani Agustina 
Published: April 2022

Sugar productivity of sugarcane is dependent on stalk yield and sucrose content which both influenced by planting material. Due to the important of planting material, this study is intended to examine the influence of planting materials i.e. cutting as a control, bud set and bud chip, toward seed quality and the early growth of cane plant in the field. This study was arranged in completly randomized design, with two factors, which are six clones of sugarcane and three types of seedling materials. The results showed that there was an interactions between both factors on germination rate, vigor index, leaf numbers, internode numbers, tiller numbers, leaf area, root volume, root fresh weight, root dry weight, shoot fresh weight, and shoot dry weight. The early growth of seedling was dependent on the clone. According to shoot fresh weight, cutting was suitable for PS 881 and Bululawang. Bud set for PS 864 clone, whereas bud chip for PSJT 941 and Kidang Kencana. Three seedling materials could be fitted to Bululawang and VMC 86-550, however for dryland farming bud sett and bud chip are preferred because such planting materials can be germinated first at the nursery and then transplantted in the field when there has been enough water content in the soil.
Kemampuan Regenerasi Akar, Kotiledon dan Daun Lima Kultivar Terung Lokal (Solanum melongena L.)
Authors: Islami Irfan , Taryono Taryono , Wulandari Rani Agustina 
Published: April 2022

Terung merupakan tanaman yang banyak digunakan sebagai tanaman model dalam perbaikan sifat karena peran dan potensi morfogenik terung yang tinggi. Perannya yang sangat penting dalam menunjang kebutuhan nutrisi dan kesehatan menjadikan banyak penelitian dilakukan untuk mendapatkan jenis terung unggul. Salah satu cara untuk mendapatkan terung jenis unggul adalah budidaya in vitro baik melalui organogenesis langsung maupun tidak langsung dengan induksi keragaman somaklonal. Faktor yang mempengaruhi budidaya in vitro terung yaitu genotipe, sumber eksplan, dan zat pengatur tumbuh. Namun, dari budidaya in vitro terung yang telah dilakukan tingkat regenerasi yang didapatkan masih rendah. Tujuan dari penelitian ini adalah mengetahui tanggapan regenerasi tiga organ sebagai bahan biakan lima kultivar terung. Perlakuan tersusun oleh 2 faktor yaitu bahan biakan dan kultivar yang ditata dalam Rancangan Acak Lengkap (RAL). Pengamatan kuantitatif dilakukan pada persentase eksplan membentuk tunas, jumlah tunas, tinggi tunas, jumlah daun, panjang daun terbesar, lebar daun terbesar, dan jumlah akar primer. Data kuantitatif hasil penelitian dianalisis menggunakan analisis varians (ANOVA) taraf 5 % dan apabila terdapat sumber ragam yang berbeda nyata, reratanya dibandingkan dengan Duncan’s Multiple Range Test (DMRT). Pengamatan kualitatif dilakukan pada kalus yang terbentuk, tunas yang terbentuk, tanggapan eksplan akar, tanggapan eksplan daun, tanggapan eksplan kotiledon. Hasil penelitian menunjukkan organ masing-masing kultivar memiliki kenampakan yang beragam. Organ kotiledon menunjukkan regenerasi paling baik berdasarkan pengamatan kualitatif dan kuantitatif khususnya pada kultivar Lokal Bantul.
Pengaruh Takaran Pupuk Kandang dan Kompos terhadap Pertumbuhan Daun Kangkung (Ipomea Reptans) Akuaponik
Authors: Sayekti Rahmi Sri , Prajitno Djoko , Indradewa Didik 
Published: April 2022

AbstractThe population increase will be accompanied by an increase in the food needed. The agricultural sector is an area which is wrought by the majority of the population in all over Indonesia. The need for land lots to do enough to be able to increase food needs people of Indonesia. Currently, function transfer land acquisition is one of the problems that make a decreased production of agricultural products. Aquaponics is an alternative to cultivate plants and fish in one place. This technique to integrate the cultivation of fish ( recirculation ) aquaculture in coupled with plants. The bucket filled with approximately 60 l then mixed with manure 250 g / 1000 l, manure 500 g / 1000 l, compost 250 g / 1000 l, compost 500 g / 1000 l, and water control without additional fertilizer. The application of organic fertilizers in the form of manure and compost Aquaponics water spinacs leaves to improved growth than without the application of organic fertilizer. The application of manure with measure 500 g / 1000 l results is the best growth aquaponics water spinach leaves. AbstrakJumlah penduduk yang meningkat akan diiringi dengan peningkatan kebutuhan akan pangan. Sektor pertanian merupakan bidang mayoritas yang dikerjakan oleh penduduk di Indonesia. Kebutuhan akan lahan yang luas harus dilakukan agar mampu mencukupi peningkatan kebutuhan pangan penduduk di Indonesia. Saat ini alih fungsi lahan merupakan salah satu masalah yang membuat produksi hasil pertanian mengalami penurunan. Akuaponik merupakan sebuah alternatif yang membudidayakan tanaman dan ikan dalam satu tempat. Teknik ini mengintegrasikan budidaya ikan (resirculating aquaculture) yang dipadukan dengan tanaman. Ember diisi air kurang lebih 60 L lalu dicampur dengan pupuk kandang 250 g/ 1000 l, pupuk kandang 500 g/ 1000 l, pupuk kompos 250 g/ 1000 l, pupuk kompos 500 g/ 1000 l, dan air kontrol tanpa penambahan pupuk. Aplikasi pupuk organik dalam bentuk pupuk kandang dan kompos mampu meningkatkan pertumbuhan daun kangkung akuaponik dibandingkan dengan tanpa aplikasi pupuk organik. Aplikasi pupuk kandang dengan takaran 500 g/1000 l memberikan hasil pertumbuhan daun kangkung akuaponik yang terbaik.
Pengujian Cocopeat dan Limbah Media Jamur (Baglog) sebagai Media Pembibitan untuk Meningkatkan Mutu Bibit Tiga Klon Teh (Camellia Sinensis (L.) O. Kuntze
Authors: Mufidah Irfanty , Wulandari Rani Agustina , Taryono Taryono 
Published: April 2022

Produksi teh menempati peringkat kedua pada sektor pertanian untuk nilai ekspor non migas sehingga teh memiliki peranan cukup penting bagi perekonomian negara. Salah satu faktor penting dalam budidaya teh adalah mutu bibit teh. Pembibitan teh dengan metode stek banyak digunakan karena dapat menghasilkan bibit dalam jumlah besar dengan mutu baik. Pembibitan teh banyak menggunakan media yang terdiri dari topsoil dan subsoil. Penggunaan topsoil dan subsoil berlebihan akan menyebabkan ketersediaannya terbatas sehingga menyebabkan kerusakan lingkungan. Cocopeat dan limbah media jamur (baglog) merupakan bahan yang dapat digunakan sebagai campuran media pembibitan. Penelitian ini bertujuan menguji penggunaan cocopeat dan baglog sebagai campuran media pembibitan teh dan mengenali komposisi yang optimal untuk media pembibitan. Penelitian ini menggunakan Rancangan perlakuan Faktorial 3 x3 yang disusun dalam Rancangan Acak Lengkap (RAL) dengan 4 ulangan. Faktor pertama berupa macam klon yaitu: GMB 3, GMB 7, dan GMB 9 ; dan faktor kedua berupa macam media tanam yaitu: tanah+cocopeat (1:2), tanah+baglog (1:2) dan pembanding yang terdiri dari topsoil dan subsoil (1:3). Data yang diperoleh diuji dengan analisis varian. Apabila pada analisis varian perlakuan menunjukkan pengaruh nyata pada taraf 5%, maka dilajutnya perbandingan rerata dengan uji beda nyata jujur (HSD/tukey) dengan taraf nyata 5%. Hasil penelitian menunjukkan bahwa media tanah+cocopeat dan media tanah+baglog belum memperbaiki mutu bibit teh.
Pengaruh Dosis Pupuk Urea dan Umur Panen terhadap Hasil Hijauan Sorgum (Sorghum bicolor (L) Moench)
Authors: Astuti Dian , Suhartanto Bambang , Umami Nafiatul , Agus Ali 
Published: April 2022

Penelitian dilakukan untuk mengetahui pertumbuhan dan produktivitas tanaman sorgum yang ditanam dengan umur panen dan dosis pemupukan urea yang berbeda. Penelitian dilakukan di lahan Pusat Inovasi Agroteknologi (PIAT) UGM selama 6 bulan, dengan desain RPPT (split split plot design) dengan menggunakan 3 faktor yaitu varietas (V) sebagai petak utama terdiri dari dua varietas yaitu V1 = Varietas Numbu dan V2 = Varietas BMR. Umur panen (U) sebagai anak petak terdiri dari 3 umur panen yaitu 50 hari (U1), 60 hari (U2) dan 70 hari (U3). Aras pupuk urea sebagai anak anak petak terdiri dari 3 aras yaitu 0 (P1), 100 (P2) dan 200 kg/ha (P3). Hasil penelitian menunjukkan bahwa umur panen (U) berpengaruh nyata (P<0,05) terhadap tinggi tanaman, hasil segar, hasil bahan kering dan hasil bahan organik. Dosis pemupukan urea berpengaruh nyata (P<0,05) terhadap tinggi tanaman, hasil segar, bahan kering dan hasil bahan organik Perlakuan umur panen 70 hari dengan pemupukan Urea 200 kg/ha (U3P3) menunjukkan nilai tertinggi pada semua variabel.
Penapisan Pendahuluan Berbagai Aksesi Padi (Oryza sativa L) Terhadap Serangan Hama Serangga dan Nematoda Parasit Tanaman
Authors: Indarti Siwi , Taryono Taryono , Supriyanta Supriyanta , Wulandari Ayu Suci 
Published: April 2022

Kajian penapisan padi terhadap serangan organisma pengganggu tanaman merupakan tahapan penting untuk mendapatkan varietas unggul. Tiga puluh empat aksesi padi dilakukan penapisan untuk mengetahui tanggapannya terhadap serangan hama serangga dan nematoda parasit tanaman. Penelitian dilakukan pada lahan persawahan irigasi yang merupakan daerah endemik kedua golongan hama tersebut. Penelitian menggunakan Rancangan Acak Kelompok (RAK) dengan 3 blok sebagai ulangan. Pengamatan berupa gejala kerusakan tanaman yang diakibatkan oleh berbagai jenis hama serangga dan nematoda parasit tanaman. Hasil penelitian menunjukkan serangan hama walang sangit pada semua aksesi padi yang diuji. Serangan wereng hijau ditemukan pada aksesi no UGM-F-00004 dan UGM-F-00008, sedangkan serangan penggerek batang hanya ditemukan pada aksesi nomor UGM-F-00005 dan UGM-F-00006. Jenis nematoda parasit tanaman yang ditemukan adalah Meloidogyne graminicola, Hirsmaniella oryzae, Helicotylenchus sp., dan Criconemoides sp. dengan tingkat populasi yang beragam. Aksesi nomor UGM-F-00028 paling rentan terhadap serangan nematoda M.graminicola. dengan populasi tertinggi > 600 nematoda per 100 g tanah dan 900 nematoda per 5 g akar.
Pengaruh Program Sapta Pesona terhadap Peningkatan Pengunjung Obyek Wisata Guci Tegal
Authors: Suyadi Suyadi 
Published: April 2022

Research intended to count the of implementation of Sapta Pesona program effects toward visitors’ quantity ofGuci Park at Kabupaten/District of Tegal, Central Java Province of Indonesia. the quantitative research methodused for this study. Data collected through questionnaires from visitors. The data analyzed by a correlationalstatistic. Instruments tested by validity test, normality test, multiple regression equations, and coefficientcorrelation feasibility. The research result showed that Sapta Pesona program affects significantly toward thequantity of visitor of Guci Park of Tegal District. Determination coefficient count 0.498 means that Sapta PesonaProgram affected to the increasing of visitors by 49.2%, while 50.2% affected by another factor as governmentregulations, service quality, visitor satisfaction, infrastructures and facilities, and so on.
AbstrakPenelitian ini bertujuan untuk mengetahui seberapa besar pengaruh pelaksanaan program sapta pesona dalammeningkatkan kuantitas pengunjung obyek wisata Guci Kabupaten Tegal. Penelitian ini menggunakan data yangberasal dari hasil penyebaran kuesioner kepada para pengunjung obyek wisata di wisata Guci Tegal baik padavariabel sapta pesona dan peningkatan pengunjung. Metode yang digunakan dalam penelitian ini adalah metodepenelitian kuantitatif deskriptif dan survei. Data hasil penyebaran kuesioner kemudian dianalisis denganmenggunakan penghitungan statistik korelasional. Pengujian yang dilakukan meliputi uji validitas, normalitas.persamaan regresi berganda, dan kelayakan koefisien regresi. Hasil penelitan menunjukkan bahwa sapta pesonamempunyai pengaruh yang signifikan terhadap peningkatan pengunjung Wisata Guci di Kabupaten Tegal,dengan koefisien determinasi KD = 0,498 hal ini berarti sapta pesona berpengaruh terhadap peningkatanpengunjung sebesar 49,8% sedangkan 50,2% dipengaruhi oleh faktor lain yang tidak diteliti. Dimana faktor laintersebut seperti peraturan pemerintah, kualitas pelayanan, kepuasan pengunjung, dan lain-lain. Dengan demikian,dapat dikatakan bahwa sapta pesona mempunyai pengaruh yang besar terhadap peningkatan pengunjung WisataGuci di Kabupaten Tegal.
Pengaruh Worklife Balance dan Employee Engagement terhadap Turnover Intention di Elzatta Hijab Jakarta
Authors: Viani Naufalia Viani Naufalia 
Published: April 2022

Penelitian ini bertujuan untuk mengetahui pengaruh worklife balance dan employee engagement terhadap turnover intention di elzatta hijab jakarta. Populasi pada penelitian ini berjumlah 60 responden, dan seluruh populasi dijadikan sampel. Metode yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif. Data yang diperoleh kemudian dianalisis menggunakan analisis jalur untuk menjawab hipotesa penelitian. Berdasarkan perhitungan analisis jalur, diperoleh analisis jalur worklife balance terhadap turnover intention sebesar 0,754 memiliki tingkat korelasi kuat. Analisis jalur employee engagement terhadap turnover intention sebesar = -0,244 memiliki tingkat korelasi rendah. Dan analisis jalur worklife balance terhadap employee engagement sebesar 0,806 memiliki tingkat korelasi tinggi. Oleh karena itu, hasil penelitian ini menyimpulkan bahwa adanya pengaruh worklife balance dan employee engagement terhadap turnover intention di Elzatta Hijab Jakarta.
ITINERÁRIO TERAPÊUTICO COMO BUSCA DO CUIDADO AO PACIENTE COM DOENÇA FALCIFORME
Authors: Roman Cassiela , Campos Marina da Silva , Bueno Denise 
Published: April 2022

A forma como são realizadas as mudanças nos processos de trabalho na área da saúde precisam ser sensíveis ao itinerário terapêutico possível dos seus usuários. No caso dos pacientes com doença falciforme (DF), é preciso analisar a necessidade de consultas frequentes em centros de referência e que a dispensação de medicamentos pós-consulta pode impactar na adesão ao tratamento. O objetivo deste estudo foi descrever o itinerário terapêutico de pacientes com DF na busca pelos medicamentos. Trata-se de um estudo qualitativo, realizado por meio de entrevista semiestruturada, realizado com 12 participantes (pacientes e cuidadores) no Centro de Referência para DF do Hospital de Clínicas de Porto Alegre, localizado na região Sul do Brasil, entre outubro e novembro de 2017. Quatro principais categorias foram identificadas: (1) Descoberta da doença, (2) Busca dos medicamentos, (3) Itinerários terapêuticos e (4) Linha do cuidado. Observou-se que existe um desconhecimento por parte dos entrevistados sobre as mudanças realizadas na forma de retirada dos medicamentos para tratamento da doença, fazendo com que seus itinerários terapêuticos estejam desorganizados no sistema de saúde. Anteriormente, os medicamentos eram retirados no centro de referência hospitalar, mas passaram a ser dispensados nas farmácias do estado no município de origem dos pacientes. A partir das informações levantadas, conclui-se que o desconhecimento relatado evidencia que a presença do profissional farmacêutico pode aproximar a dispensação do medicamento da realidade das pessoas com DF que necessitam de um olhar particularizado na atenção à saúde.
SÍNDROMES HIPERTENSIVAS NA GESTAÇÃO: PERFIL CLÍNICO MATERNO E CONDIÇÃO NEONATAL AO NASCER
Authors: Lopes Lhayse dos Santos , França Alba Maria Bomfim de , Pedrosa Aldrya Ketly , Miyazawa Ana Paula 
Published: April 2022

Este trabalho tem como objetivo identificar o perfil clínico de mulheres com Síndromes Hipertensivas na Gestação (SGH) e seus neonatos, caracterizando o perfil sociodemográfico e obstétrico materno, além de descrever as condições clínicas neonatais ao nascer. Trata-se de um estudo descritivo, transversal, com abordagem quantitativa, a partir de 190 prontuários de mulheres que tiveram seus partos realizados em duas maternidades referência para alto risco em Alagoas, Brasil, e seus respectivos neonatos. Identificou-se que as mulheres eram jovens, pardas, multíparas, com parto a termo por cesariana. A SHG mais encontrada foi a pré-eclâmpsia; também foram encontrados casos de eclampsia e síndrome HELLP. Os neonatos nasceram com peso adequado para a idade gestacional (AIG) e índice de Apgar ≥ 7, sendo que 52,63% apresentaram intercorrência ao nascer, dentre elas, a síndrome do desconforto respiratório. A partir dos dados encontrados, considera-se que o perfil clínico e obstétrico materno é prejudicado, porém, o desfecho neonatal foi considerado positivo frente a essa patologia. Por isso a importância da assistência pré-natal qualificada, minimizando riscos e evitando complicações por meio de medidas preventivas.
USO MEDICINAL DA CANNABIS SATIVA E SUA REPRESENTAÇÃO SOCIAL
Authors: Santos Solange Oliveira , Miranda Marlene Barreto Santos 
Published: April 2022

Trata-se de uma revisão não sistemática da literatura, descritiva, exploratória e de caráter qualitativo. Tem o objetivo de descrever a importância do uso medicinal da Cannabis sativa, apontando as representações sociais sobre a temática, com vistas a reduzir a falta de informação sobre a substância. Diante do cenário de preconceito em relação à cannabis conclui-se que são inúmeros os dados históricos sobre o consumo da substância, além dos consistentes estudos sobre o seu uso medicinal, porém ainda há a necessidade da formulação/mudança de estratégias que sirvam de subsídios/dados à formação de profissionais, principalmente das áreas de saúde, para serem aplicados nas suas práticas futuras de intervenção junto aos usuários de cannabis medicinal, bem como na implementação de políticas públicas de educação e promoção da saúde. A temática sobre o consumo medicinal da cannabis sativa surgiu após a veiculação através da mídia televisiva de uma entrevista, sobre uma criança, Anny Fisher, portadora de uma síndrome rara, que causava grandes episódios de convulsões ao dia, e após o uso do Canabidiol, um medicamento a base de maconha, houve uma diminuição considerável das crises convulsivas. A partir dessa constatação de que um simples medicamento poderia minimizar a dor de muitas pessoas e que todo o preconceito que envolve essa substância, não tem nenhum respaldo científico, algumas famílias decidiram travar uma grande batalha jurídica, política e social no sentido de conseguir junto ao órgão regulador, nesse caso a ANVISA, autorização para importação do produto para uso medicinal.