bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early blood pressure changes during systemic thrombolysis and its association with unexplained early neurological deterioration in small subcortical infarct
Authors: Wei Xiu'e , Duan Zuowei , Zhai Yujia , Zhang Cuicui , Zhang Jun , Hu Ting , Liu Tengfei , Liu Zhenqian , Xu Jiang , Liu Haiyan , Rong Liangqun 
Published: July 2022

AbstractEarly neurological deterioration (END), observed in the acute phase of small subcortical infarct treated with intravenous thrombolysis (IVT), is not uncommon in these patients. However, in over half of the END cases, the exact cause is yet incompletely understood, which is so‐called unexplained END (unEND). Our aim was to investigate the association of early blood pressure (BP) changes with unEND in patients with small subcortical infarct in the perforator territory of middle cerebral artery treated with IVT. Consecutive patients with acute small subcortical infarct treated with IVT were enrolled in this study. unEND was defined as≧2‐point increase of NIHSS from baseline to 24 hours, without straightforward causes. BP excursions and BP variability were calculated and compared between patients with unNED and those without. A total of 168 patients with acute small subcortical infarct were included. Of them, there were 29 patients with unEND and 139 without END. During the first 24 hours following IVT, 66 (39.29%) patients had at least one BP excursion. Logistic regression analyses indicated that BP excursion presence (OR = 3.185, 95% CI: 1.238‐8.198), SBP excursion presence (OR = 3.535, 95% CI: 1.366‐9.143), and number of SBP excursion (OR = 1.466, 95% CI: 1.090‐1.973) were independently associated with unEND. Although SBPSD (P < .001) and SBPCV (P < .001) were higher in patients with unEND than those without END, none of the parameters of BP variability predicted unEND in multivariate analyses. BP excursions above guideline thresholds during the first 24 hours following IVT for small subcortical infarct are common and are independently associated with unEND.
SARS‐CoV‐2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytes
Authors: de Oliveira Lilian Gomes , de Souza Angelo Yan , Yamamoto Pedro , Carregari Victor Corasolla , Crunfli Fernanda , Reis‐de‐Oliveira Guilherme , Costa Lícia , Vendramini Pedro Henrique , Duque Érica Almeida , dos Santos Nilton Barreto , Firmino Egidi Mayara , Paiva Isadora Marques , Almeida Glaucia Maria , Sebollela Adriano , Polonio Carolina Manganeli , Zanluqui Nagela Ghabdan , de Oliveira Marília Garcia , da Silva Patrick , Davanzo Gustavo Gastão , Ayupe Marina Caçador , Salgado Caio Loureiro , de Souza Filho Antônio Francisco , de Araújo Marcelo Valdemir , Silva‐Pereira Taiana Tainá , de Almeida Campos Angélica Cristine , Góes Luiz Gustavo Bentim , dos Passos Cunha Marielton , Caldini Elia Garcia , D'Império Lima Maria Regina , Fonseca Denise Morais , de Sá Guimarães Ana Márcia , Minoprio Paola Camargo , Munhoz Carolina Demarchi , Mori Cláudia Madalena Cabrera , Moraes‐Vieira Pedro Manoel , Cunha Thiago Mattar , Martins‐de‐Souza Daniel , Peron Jean Pierre Schatzmann 
Published: July 2022

AbstractCOVID‐19 causes more than million deaths worldwide. Although much is understood about the immunopathogenesis of the lung disease, a lot remains to be known on the neurological impact of COVID‐19. Here, we evaluated immunometabolic changes using astrocytes in vitro and dissected brain areas of SARS‐CoV‐2 infected Syrian hamsters. We show that SARS‐CoV‐2 alters proteins of carbon metabolism, glycolysis, and synaptic transmission, many of which are altered in neurological diseases. Real‐time respirometry evidenced hyperactivation of glycolysis, further confirmed by metabolomics, with intense consumption of glucose, pyruvate, glutamine, and alpha ketoglutarate. Consistent with glutamine reduction, the blockade of glutaminolysis impaired viral replication and inflammatory response in vitro. SARS‐CoV‐2 was detected in vivo in hippocampus, cortex, and olfactory bulb of intranasally infected animals. Our data evidence an imbalance in important metabolic molecules and neurotransmitters in infected astrocytes. We suggest this may correlate with the neurological impairment observed during COVID‐19, as memory loss, confusion, and cognitive impairment.image
Efficacy of non‐pharmacological interventions to reduce pain in people with dementia: A systematic review and meta‐analysis
Authors: Saragih Ita Daryanti , Suarilah Ira , Son Nguyen Thi , Lee Bih‐O. 
Published: July 2022

AbstractAims and objectivesTo identify the efficacy of non‐pharmacological interventions designed to reduce pain in people with dementia.BackgroundPain is prevalent among patients with dementia but frequently remains untreated. Although non‐pharmacological interventions have been used to reduce pain in people with dementia, the efficacy of these interventions for pain management in people with dementia has not been thoroughly synthesised.DesignSystematic review and meta‐analysis.MethodsThe study was conducted in accordance with PRISMA guidelines and Cochrane criteria for systematic reviews. A comprehensive search was performed using the Academic Search Complete, CINAHL, Cochrane Library, EMBASE, MEDLINE, PubMed, OVID and Web of Science databases, from databases inception to 13 March 2022. The modified Cochrane risk‐of‐bias tool (ROB‐2) was used to evaluate the methodological quality of each included study. Standardised mean differences (SMDs) with 95% confidence intervals (CIs) were synthesised using a random‐effects model to assess the efficacy of non‐pharmacological interventions for reducing pain in people with dementia (using Stata 16.0).ResultsThe final analysis assessed 12 studies, including 989 persons with dementia. Non‐pharmacological interventions were found to reduce pain in 4–8 weeks after the interventions (SMD: −0.32; 95% CI: −0.62 to −0.02). However, the effects of intervention frequency and patient age remain unknown.ConclusionsNon‐pharmacological interventions are effective for reducing pain in people with dementia. Further investigations remain necessary to explore the effectiveness of specific non‐pharmacological therapies for pain reduction in people with dementia (e.g. aromatherapy, play activity, singing or robotic care).Relevance to clinical practiceThe findings of this study can guide healthcare practitioners when considering the use of non‐pharmacological pain management methods for people with dementia and may improve the implementation of these methods in clinical practice.Patient or public contributionsThe study suggests non‐pharmacological interventions to reduce pain and underlines the relevance of health provider's viewpoints. The types, duration and length of follow‐up of non‐pharmacological interventions can be offered based on patient's conditions and the standard of clinical practice.
Clinical judgement in nursing – An evolutionary concept analysis
Authors: Connor Justine , Flenady Tracy , Massey Deb , Dwyer Trudy 
Published: July 2022

AbstractAimsThe aim of this concept analysis was to develop a contemporary operational definition of Clinical Judgement in nursing.DesignConcept analysis.MethodsRodgers' evolutionary method of concept analysis. Throughout the study, the authors followed the SRQR checklist.ResultsThis concept analysis guided the development of an operational definition of clinical judgement, within the context of nursing, articulated as Clinical judgement is a reflective and reasoning process that draws upon all available data, is informed by an extensive knowledge base and results in the formation of a clinical conclusion.ConclusionThe purpose of this concept analysis was to propose a detailed definition of clinical judgement in nursing, that reflected its theoretical base within today's contemporary healthcare system. Using Rodgers' evolutionary method of concept analysis, surrogate terms, attributes, antecedents and consequences were identified, and a contemporary definition was developed.No patient or public contribution was required to design or undertake this research.
‘biogeom’: An R package for simulating and fitting natural shapes
Authors: Shi Peijian , Gielis Johan , Quinn Brady K. , Niklas Karl J. , Ratkowsky David A. , Schrader Julian , Ruan Honghua , Wang Lin , Niinemets Ülo 
Published: July 2022

AbstractMany natural objects exhibit radial or axial symmetry in a single plane. However, a universal tool for simulating and fitting the shapes of such objects is lacking. Herein, we present an R package called ‘biogeom’ that simulates and fits many shapes found in nature. The package incorporates novel universal parametric equations that generate the profiles of bird eggs, flowers, linear and lanceolate leaves, seeds, starfish, and tree‐rings, and three growth‐rate equations that generate the profiles of ovate leaves and the ontogenetic growth curves of animals and plants. ‘biogeom’ includes several empirical datasets comprising the boundary coordinates of bird eggs, fruits, lanceolate and ovate leaves, tree rings, seeds, and sea stars. The package can also be applied to other kinds of natural shapes similar to those in the datasets. In addition, the package includes sigmoid curves derived from the three growth‐rate equations, which can be used to model animal and plant growth trajectories and predict the times associated with maximum growth rate. ‘biogeom’ can quantify the intra‐ or interspecific similarity of natural outlines, and it provides quantitative information of shape and ontogenetic modification of shape with important ecological and evolutionary implications for the growth and form of the living world.
Parental atopy and risk of atopic dermatitis in the first two years of life in the BASELINE birth cohort study
Authors: O'Connor Cathal , Livingstone Vicki , Hourihane Jonathan O'. B. , Irvine Alan D. , Boylan Geraldine , Murray Deirdre 
Published: July 2022

AbstractBackgroundAtopic dermatitis (AD) has a strong genetic basis. The objective of this study was to assess the association between parental atopy and AD development by 2 years.MethodsA secondary data analysis of the BASELINE Birth Cohort study was performed (n = 2183). Parental atopy was self‐reported at 2 months. Infants were examined for AD by trained health care professionals at 6, 12, and 24 months. Variables extracted from the database related to skin barrier function, early skincare, parental atopy, and AD. Statistical analysis adjusted for potential confounding variables.ResultsComplete data on AD status were available for 1505 children at 6, 12, and 24 months. Prevalence of AD was 18.6% at 6 months, 15.2% at 12 months, and 16.5% at 24 months. Adjusted odds ratios (95% CIs) following multivariable analysis were 1.57 (1.09–2.25) at 6 months and 1.66 (1.12–2.46) at 12 months for maternal AD; 1.90 (1.28–2.83) at 6 months and 1.85 (1.20–2.85) at 24 months for paternal AD; 1.76 (1.21–2.56) at 6 months and 1.75 (1.16–2.63) at 12 months for maternal asthma; and 1.70 (1.19–2.45) at 6 months, 1.86 (1.26–2.76) at 12 months, and 1.99 (1.34–2.97) at 24 months for paternal asthma. Parental rhinitis was only associated with AD with maternal rhinitis at 24 months (aOR (95% CI): 1.79 (1.15–2.80)).ConclusionParental AD and asthma were associated with increased risk of objectively diagnosed AD in offspring in this contemporary cohort.
Characterization and differentiation of pollen lipidomes and proteomes from different intrafloral stamens in heterantherous Senna bicapsularis
Authors: Huang H. , Gong Z. 
Published: July 2022

ABSTRACT
Numerous compounds in pollen can affect the foraging decision‐making of bees. Clarification of phytochemical components and identification of key substances for bee foraging preference in pollen are essential steps for apiculture and developing a conservation strategy.
Senna bicapsularis, a heterantherous plant that possesses three different stamen types in the same flower, among which bees forage selectively, provides us with an ideal research model for identification of potential substances of bee foraging preference. The lipid and protein compositions of pollen from the anthers of different stamens of S. bicapsularis were investigated and compared.
The polyunsaturated fatty acids (PUFAs) and monounsaturated FAs (MUFAs) were highest among lipid molecules in pollen from short (S) stamens than from long (L) and medium (M) stamens. This result is consistent with the FA content measurement, showing the highest FAs and UFAs content in S pollen, especially α‐linolenic acid. We inferred that α‐linolenic acid might be one of the key substances for bee foraging preference in pollen. Moreover, proteomic analysis showed that several differentially expressed proteins involved in lipid biosynthesis were highly accumulated in S pollen, such as choline kinase 2, 3‐oxoacyl‐ACP synthase‐like protein and choline/ethanolamine phosphotransferase 1, in line with the highest FA content of S pollen. Additionally, DEPs involved in ‘starch and sucrose metabolism’, ‘phenylpropanoid biosynthesis’ and ‘cyanoamino acid metabolism’ were more represented in S compared with L and M pollen.
The study suggests that differences in proteomic and lipidomic profiling among the three different stamen types might affect foraging decision‐making of bumblebees.
Proteomic analysis of iTRAQ in melatonin‐treated sheep epididymal epithelial cells
Authors: Ge Wenbo , Xiao Longfei , Duan Hongwei , Zhao Xingxu , Li Jianyong , Hu Junjie 
Published: July 2022

AbstractDuring maturation, spermatozoa acquire motility and fertilizing capacity as they transit through the epididymis. Melatonin is a lipophilic hormone with multiple functions in regulating the fertility. Previous studies have shown that melatonin affected the capacitation or maturation of sperm in the epididymis. The aim of this study was to investigate the effects of melatonin on epididymal caput epithelial cells in sheep. In the study, we used iTRAQ labelling coupled with LC–MS/MS for quantitative identification of differentially expressed proteins in melatonin‐treated sheep epididymal caput epithelial cells. We identified 69 differentially expressed protein; 41 were upregulated and 28 were downregulated in samples from sheep in melatonin treated. We validated the differential expression of a subset of these proteins using qPCR and Western blot. Gene ontology annotation identified that the differentially expressed proteins function in cellular processes and metabolic processes. Notably, five of the differentially expressed proteins as SOD1, COL1A1, PRM1, NQO2, and FN1 are involved in sperm migration and sperm maturation. KEGG enrichment analysis demonstrated significant enrichment in several cardiac‐related pathways, such as “PI3K‐Akt signaling pathway”, “AGE‐RAGE signaling pathway in diabetic complications”, “ECM‐receptor interaction”, and “Ribosome”. Our results suggest that candidate biomarker (SOD1, COL1A1, PRM1, NQO2, and FN1) discovery can aid in understanding sperm development and maturation in sheep. These results provide insights into the potential mechanisms of melatonin regulation of sperm maturation in epididymal caput epithelial cells.
Support for the environment post‐transition? Material concerns and policy tradeoffs
Authors: Moldogaziev Temirlan T. , Krause Rachel M. , Arnold Gwen , Long Le Ahn Nguyen , Ruseva Tatyana , Silvia Chris , Witko Christopher 
Published: July 2022

AbstractThough many individuals are aware of the need to address environmental concerns, fewer are willing to pay for climate action or think the environment should be a priority for government spending. One compelling reason is that they prioritize using scarce resources to address immediate material concerns. This is particularly likely for individuals facing absolute material scarcity or for those who think they are relatively economically worse off, especially in contexts characterized by rapid transformation and volatility in the levels and quality of social welfare provision. To test these expectations, we analyze survey data from formerly Communist economies, which today find themselves with vastly different fortunes. Empirical findings suggest that absolute and relative material scarcity affect opinions regarding government spending on, and the willingness to pay more for, environmental action. However, willingness to pay more for government public services, inclusive of anti‐poverty initiatives, has an impact on willingness to pay more for climate action, but in counter‐intuitive ways. Overall, the results appear to suggest that explicitly addressing and relating individual living standards and inequality with environmental concerns may expand support for climate action.
Spatiotemporal ETAS Model with a Renewal Main-Shock Arrival Process
Authors: Stindl Tom , Chen Feng 
Published: July 2022

AbstractWe propose a spatiotemporal point process model that enhances the classical Epidemic-Type Aftershock Sequence (ETAS) model. This is achieved with the introduction of a renewal main-shock arrival process and we call this extension the renewal ETAS (RETAS) model. This modification is similar in spirit to the renewal Hawkes (RHawkes) process but the conditional intensity process supports a spatial component. It empowers the main-shock intensity to reset upon the arrival of main-shocks. This allows for heavier clustering of main-shocks than the classical spatiotemporal ETAS model. We introduce a likelihood evaluation algorithm for parameter estimation and provide a novel procedure to evaluate the fitted model's goodness-of-fit (GOF) based on a sequential application of the Rosenblatt transformation. A simulation algorithm for the RETAS model is outlined and used to validate the numerical performance of the likelihood evaluation algorithm and GOF test procedure. We illustrate the proposed model and methods on various earthquake catalogues around the world each with distinctly different seismic activity. These catalogues demonstrate the RETAS model's additional flexibility in comparison to the classical spatiotemporal ETAS model and emphasizes the potential for superior modelling and forecasting of seismicity.
Metabolomics‐based researches in autoimmune liver disease: A mini‐review
Authors: Adil Nurmeen , Siddiqui Amna Jabbar , Musharraf Syed Ghulam 
Published: July 2022

AbstractMetabolomics offers a promising approach to studying metabolites in the biological system. It offers new opportunities to assess the disease progression and biomarker selection and also provides a pathophysiological understanding of the disease. Autoimmune liver disease is a major public health concern worldwide. Three main categories of this disease include autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). Their pathogenesis is poorly understood till now. If not treated properly then it will eventually lead to liver cirrhosis and ultimately liver failure occurs. This review summarizes a comprehensive overview of human and animal studies intended to identify the role of metabolomics in all three types of autoimmune liver disease so far. Furthermore, a detailed discussion has been carried out on the disturbed metabolic pathways, including carbohydrate, amino acid, fatty acids, lipids, and bile acid metabolism. Till now, limited work has been done regarding the diagnostic assessment, type of therapy, and disease management for each type. Further research should be conducted to grasp this disease at an earlier stage and to prevent disease‐related complications.
Translating community resilience theory into practice: A deliberative Delphi approach
Authors: Glass Jayne , McMorran Rob , Currie Margaret , McKee Annie , Pinker Annabel , Reed Mark , Meador Elliot , Markantoni Marianna 
Published: July 2022

AbstractDespite the availability of important theoretical insights that could enhance the resilience of rural communities to complex challenges, there is a paucity of guidance on how to apply these insights in practice. This article therefore presents and assesses a deliberative research process using the Delphi technique to elicit expert knowledge from 22 academics, community practitioners and policymakers working in roles related to community resilience delivery in rural Scotland. The participants co‐produced an operational framework for community resilience, with support from researchers who facilitated the three‐stage, interactive process. The methodology enabled participants to work together in an iterative and inclusive manner, culminating in the collective development of a conceptual framework consisting of eight resilience‐enabling factors and corresponding criteria for monitoring change, which can be used to plan practical action and provide feedback to enable ongoing adaptation. The process also produced an in‐depth understanding of participants’ perceptions of rural community resilience, identified key factors that enable or impede rural community resilience, analysed the potential to assess community resilience and explored scale‐related issues. The article explores the implications of this framework for those working to make rural communities more resilient and reflects on the benefits and wider application of this type of research approach for developing shared understandings of complex concepts.
2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 6: Defining rational use of thrombolytics
Authors: Sharp Claire R. , Blais Marie‐Claude , Boyd Corrin J. , Brainard Benjamin M. , Chan Daniel L. , de Laforcade Armelle , Goggs Robert , Guillaumin Julien , Lynch Alex , Mays Erin , McBride Duana , Rosati Tommaso , Rozanski Elizabeth A. 
Published: July 2022

AbstractObjectivesTo systematically review available evidence and establish guidelines related to the use of thrombolytics for the management of small animals with suspected or confirmed thrombosis.DesignPICO (Population, Intervention, Control, and Outcome) questions were formulated, and worksheets completed as part of a standardized and systematic literature evaluation. The population of interest included dogs and cats (considered separately) and arterial and venous thrombosis. The interventions assessed were the use of thrombolytics, compared to no thrombolytics, with or without anticoagulants or antiplatelet agents. Specific protocols for recombinant tissue plasminogen activator were also evaluated. Outcomes assessed included efficacy and safety. Relevant articles were categorized according to level of evidence, quality, and as to whether they supported, were neutral to, or opposed the PICO questions. Conclusions from the PICO worksheets were used to draft guidelines, which were subsequently refined via Delphi surveys undertaken by the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) working group.ResultsFourteen PICO questions were developed, generating 14 guidelines. The majority of the literature addressing the PICO questions in dogs is experimental studies (level of evidence 3), thus providing insufficient evidence to determine if thrombolysis improves patient‐centered outcomes. In cats, literature was more limited and often neutral to the PICO questions, precluding strong evidence‐based recommendations for thrombolytic use. Rather, for both species, suggestions are made regarding considerations for when thrombolytic drugs may be considered, the combination of thrombolytics with anticoagulant or antiplatelet drugs, and the choice of thrombolytic agent.ConclusionsSubstantial additional research is needed to address the role of thrombolytics for the treatment of arterial and venous thrombosis in dogs and cats. Clinical trials with patient‐centered outcomes will be most valuable for addressing knowledge gaps in the field.