bluuebunny/crossref_metadata_2025_split huggingface dataset:
AntiPD-L1 antibody conjugated Au-SPIOs nanoplatform for enhancing radiosensitivity and triggering anti-tumor immune response
Authors: Du Chengrun , Jiang Jianyun , Wan Caifeng , Pan Guangsen , Kong Fangfang , Zhai Ruiping , Hu Chaosu , Ying Hongmei 
Published: November 2022

AbstractTo improve radiotherapy effect by inducing more toxicity for tumors and less for normal tissue and switching immunosuppressive microenvironment caused by expression of PD-L1 and tumor-associated macrophages (TAMs) to immunoreactive microenvironment, we designed a PD-L1-targeted nanoplatform consisting of gold nanoparticles and superparamagnetic iron oxide nanoparticles (antiPD-L1-SPIOs@PLGA@Au). In vivo T2-weighted images, the best contrast effect of tumor was achieved two hours after intravenous injection of antiPD-L1-SPIOs@PLGA@Au. The tumor control caused by irradiation combined with antiPD-L1-SPIOs@PLGA@Au was better than that by radiotherapy alone in clone formation assay and B16F10 subcutaneous tumor model. Radiosensitivity enhancement induced by the addition of antiPD-L1-SPIOs@PLGA@Au was achieved by increasing ROS production and attenuating DNA damage repair. AntiPD-L1-SPIOs@PLGA@Au could promote the polarization of tumor-associated macrophages (TAMs) to M1 and reverse the immunosuppression caused by TAMs. By increasing the expression of CRT in tumor and blocking the PD-L1/PD pathway, antiPD-L1-SPIOs@PLGA@Au with radiation activated the anti-tumor immune response. In conclusion, antiPD-L1-SPIOs@PLGA@Au could be used as a radiosensitizer and a MRI contrast targeting PD-L1, with the functions of blocking the PD-L1/PD-1 immune checkpoint pathway and reversing the immunosuppression caused by TAMs.
Detection of mandibular fractures on panoramic radiographs using deep learning
Authors: Vinayahalingam Shankeeth , van Nistelrooij Niels , van Ginneken Bram , Bressem Keno , Tröltzsch Daniel , Heiland Max , Flügge Tabea , Gaudin Robert 
Published: November 2022

AbstractMandibular fractures are among the most frequent facial traumas in oral and maxillofacial surgery, accounting for 57% of cases. An accurate diagnosis and appropriate treatment plan are vital in achieving optimal re-establishment of occlusion, function and facial aesthetics. This study aims to detect mandibular fractures on panoramic radiographs (PR) automatically. 1624 PR with fractures were manually annotated and labelled as a reference. A deep learning approach based on Faster R-CNN and Swin-Transformer was trained and validated on 1640 PR with and without fractures. Subsequently, the trained algorithm was applied to a test set consisting of 149 PR with and 171 PR without fractures. The detection accuracy and the area-under-the-curve (AUC) were calculated. The proposed method achieved an F1 score of 0.947 and an AUC of 0.977. Deep learning-based assistance of clinicians may reduce the misdiagnosis and hence the severe complications.
A real-world pharmacovigilance study of FDA Adverse Event Reporting System (FAERS) events for osimertinib
Authors: Yin Yanchao , Shu Yamin , Zhu Junru , Li Feie , Li Juan 
Published: November 2022

AbstractOsimertinib was a third-generation, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), which approved by the US Food and Drug Administration (FDA) in 2015 for treatment of non-small cell lung cancer (NSCLC). Our study was to explore the adverse events (AEs) caused by osimertinib through data mining of the US FDA Adverse Event Reporting System (FAERS), and provide reference for clinical safety. Data of osimertinib were collected from the FAERS database covering the period from first quarter of 2016 to the fourth quarter of 2021. Disproportionality analyses was employed to quantify the associated AE signals of osimertinib and detect the risk signals from the data in the FAERS database. Reporting odds ratio (ROR) was used to detect the risk signals from the data in the FAERS database. The definition relied on system organ class (SOCs) and preferred terms (PTs) by the Medical Dictionary for Regulatory Activities (MedDRA). Totally, 9,704,33 reports were collected from the FAERS database, 10,804 reports of osimertinib were identified as the ‘primary suspected (PS)’ AEs. Osimertinib induced AEs occurred in 27 organ systems. 68 significant disproportionality PTs satisfying with the four algorithms were retained at the same time. Unexpected significant AEs such as scrotal volvulus, hepatic function abnormal, venous thromboembolisms might also occur. The median onset time of osimertinib-associated AEs was 58 days (interquartile range [IQR] 14–212 days), and the majority of the AEs occurred within the first 30 days after osimertinib initiation. Our study found significant new AEs signals of osimertinib and might provide support for clinical monitoring and risk identification of osimertinib.
Genome-wide transcriptome analysis of the orphan crop tef (Eragrostis tef (Zucc.) Trotter) under long-term low calcium stress
Authors: Ligaba-Osena Ayalew , Salehin Mohammad , Numan Muhammad , Wang Xuegeng , Choi Sang-Chul , Jima Dereje , Bobay Louis-Marie , Guo Wanli 
Published: November 2022

AbstractCalcium (Ca2+) is one of the essential mineral nutrients for plant growth and development. However, the effects of long-term Ca2+deficiency in orphan crops such as Tef [(Eragrostis tef) (Zucc.) Trotter], which accumulate high levels of Ca in the grains, remained unknown. Tef is a staple crop for nearly 70 million people in East Africa, particularly in Ethiopia and Eritrea. It is one of the most nutrient-dense grains, and is also more resistant to marginal soils and climatic conditions than main cereals like corn, wheat, and rice. In this study, tef plants were grown in a hydroponic solution containing optimum (1 mM) or low (0.01 mM) Ca2+, and plant growth parameters and whole-genome transcriptome were analyzed. Ca+2-deficient plants exhibited leaf necrosis, leaf curling, and growth stunting symptoms. Ca2+deficiency significantly decreased root and shoot Ca, potassium (K), and copper content in both root and shoots. At the same time, it greatly increased root iron (Fe) content, suggesting the role of Ca2+in the uptake and/or translocation of these minerals. Transcriptomic analysis using RNA-seq revealed that members of Ca2+channels, including the cyclic nucleotide-gated channels and glutamate receptor-like channels, Ca2+-transporters, Ca2+-binding proteins and Ca2+-dependent protein kinases were differentially regulated by Ca+2treatment. Moreover, several Fe/metal transporters, including members of vacuolar Fe transporters, yellow stripe-like, natural resistance-associated macrophage protein, and oligo-peptide transporters, were differentially regulated between shoot and root in response to Ca2+treatment. Taken together, our findings suggest that Ca2+deficiency affects plant growth and mineral accumulation by regulating the transcriptomes of several transporters and signaling genes.
Age- and cell cycle-related expression patterns of transcription factors and cell cycle regulators in Müller glia
Authors: Kato Maki , Sudou Norihiro , Nomura-Komoike Kaori , Iida Tomohiro , Fujieda Hiroki 
Published: November 2022

AbstractMammalian Müller glia express transcription factors and cell cycle regulators essential for the function of retinal progenitors, indicating the latent neurogenic capacity; however, the role of these regulators remains unclear. To gain insights into the role of these regulators in Müller glia, we analyzed expression of transcription factors (Pax6, Vsx2 and Nfia) and cell cycle regulators (cyclin D1 and D3) in rodent Müller glia, focusing on their age- and cell cycle-related expression patterns. Expression of Pax6, Vsx2, Nfia and cyclin D3, but not cyclin D1, increased in Müller glia during development. Photoreceptor injury induced cell cycle-associated increase of Vsx2 and cyclin D1, but not Pax6, Nfia, and cyclin D3. In dissociated cultures, cell cycle-associated increase of Pax6 and Vsx2 was observed in Müller glia from P10 mice but not from P21 mice. Nfia levels were highly correlated with EdU incorporation suggesting their activation during S phase progression. Cyclin D1 and D3 were transiently upregulated in G1 phase but downregulated after S phase entry. Our findings revealed previously unknown links between cell cycle progression and regulator protein expression, which likely affect the cell fate decision of proliferating Müller glia.
Noble gas isotopes reveal degassing-derived eruptions at Deception Island (Antarctica): implications for the current high levels of volcanic activity
Authors: Álvarez-Valero Antonio M. , Sumino Hirochika , Caracausi Antonio , Sánchez Antonio Polo , Burgess Ray , Geyer Adelina , Borrajo Javier , Rodríguez José A. Lozano , Albert Helena , Aulinas Meritxell , Núñez-Guerrero Elena 
Published: November 2022

AbstractDeception Island is one of the most active volcanoes in Antarctica with more than twenty explosive eruptions in the past two centuries. Any future volcanic eruption(s) is a serious concern for scientists and tourists, will be detrimental to marine ecosystems and could have an impact to global oceanographic processes. Currently, it is not possible to carry-out low and high frequency volcanic gas monitoring at Deception Island because of the arduous climatic conditions and its remote location. Helium, neon and argon isotopes measured in olivine samples of the main eruptive events (pre-, syn- and post caldera) offer insights into the processes governing its volcanic history. Our results show that: (i) ascending primitive magmas outgassed volatiles with a MORB-like helium isotopic signature (3He/4He ratio); and (ii) variations in the He isotope ratio, as well as intensive degassing evidenced by fractionated 4He/40Ar* values, occurred before the beginning of the main eruptive episodes. Our results show how the pre-eruptive noble gas signals of volcanic activity is an important step toward a better understanding of the magmatic dynamics and has the potential to improve eruption forecasting.
Storing high temperature solar thermal energy in shallow depth artificial reservoir for space heating
Authors: Bu Xianbiao , Jiang Kunqing , Guo Zhipeng 
Published: November 2022

AbstractThe discontinuous and unstable characteristics of solar energy limit its application in the space heating field, while aquifer thermal energy storage (ATES), as a seasonal thermal energy storage pattern, is a feasible way of solving these problems faced by solar space heating and however, low temperature ATES must not exceed 25–30 °C while high temperature ATES has low recovery efficiency. Here a novel scheme of storing high temperature solar thermal energy into a shallow depth artificial reservoir (SDAR) is proposed. By innovatively storing thermal energy into rocks rather than aquifer, the recovery efficiency improves from 46% for ATES to 90% for SDAR, and the thermal power increases from 309 kW for deep borehole heat exchanger to 1970 kW for SDAR. SDAR has no special requirement to rock temperature and can thus be created in shallow buried depth rocks, leading not only to a reduction of engineering cost but also an expansion of application scope. To further avoid risk of induced seismicity caused by hydraulic fracturing and reduce cost, the abandoned oil and gas fields and mines can be reused as the artificial reservoir.
Lung CCR6−CXCR3− type 2 helper T cells as an indicator of progressive fibrosing interstitial lung diseases
Authors: Tsukuda Tsukie Kin , Ohnishi Hiroshi , Fujimoto Minoru , Nakatani Yu , Takamatsu Kazufumi , Naka Tetsuji , Yokoyama Akihito 
Published: November 2022

AbstractProgressive fibrosing interstitial lung diseases (PF-ILDs) have a poor prognosis and may be resistant to corticosteroids and/or immunosuppressants, but antifibrotic therapies such as nintedanib and pirfenidone have been shown to slow the deterioration of lung function. The aim of this study was to identify the characteristic cellular profile of bronchoalveolar lavage fluid at diagnostic bronchoscopy for predicting PF-ILDs, defined as fibrotic diseases on chest high-resolution computed tomography with more than a 5% relative decline in the percent predicted value of forced vital capacity (FVC) over 6 months. The proportions of inflammatory cells, CCR6−CXCR3− T helper type 2 (Th2) cells among conventional CD4+ T cells in bronchoalveolar lavage fluid (BALF) and peripheral blood, were measured by flowcytometry. The proportion of lymphocytes in BALF was significantly higher in non-PF-ILD patients than in PF-ILD patients. The proportion of Th2 cells in BALF, but not in peripheral blood, was significantly higher in PF-ILD patients than in non-PF-ILD patients. Multivariate analysis showed that a greater population of Th2 cells in BALF was the only indicator for PF-ILDs. An increased proportion of Th2 cells in BALF is associated with greater deterioration of lung function in fibrotic interstitial lung diseases.
Transfer efficiency and impact on disease phenotype of differing methods of gut microbiota transfer
Authors: Zhang Chunye , Shi Yushu , Burch Matthew , Olthoff Benjamin , Ericsson Aaron C. , Franklin Craig L. 
Published: November 2022

AbstractTo test causal relationships between complex gut microbiota (GM) and host outcomes, researchers frequently transfer GM between donor and recipient mice via embryo transfer (ET) rederivation, cross-fostering (CF), and co-housing. In this study, we assess the influence of the transfer method and the differences in baseline donor and recipient microbiota richness, on transfer efficiency. Additionally, recipient mice were subjected to DSS-induced chronic colitis to determine whether disease severity was affected by GM transfer efficiency or features within the GM. We found that the recipient’s genetic background, the baseline richness of donor and recipient GM, and the transfer method all influenced the GM transfer efficiency. Recipient genetic background and GM both had significant effects on DSS colitis severity and, unexpectedly, the transfer method was strongly associated with differential disease severity regardless of the other factors.
Source discrimination of mine water based on the random forest method
Authors: Yang Zhenwei , Lv Hang , Xu Zhaofeng , Wang Xinyi 
Published: November 2022

AbstractMachine learning is one of the widely used techniques to pattern recognition. Use of the machine learning tools is becoming a more accessible approach for predictive model development in preventing engineering disaster. The objective of the research is to for estimation of water source using the machine learning tools. Random forest classification is a popular machine learning method for developing prediction models in many research settings. The type of mine water in the Pingdingshan coalfield is classified into surface water, Quaternary pore water, Carboniferous limestone karst water, Permian sandstone water, and Cambrian limestone karst water. Each type of water is encoded with the number 0–4. On the basis of hydrochemical data processing, a random forests model is designed and trained with the hydrochemical data. With respect to the predictive accuracy and robustness, fourfold cross-validation (CV) is adopted for the model training. The results show that the random forests model presented here provides significant guidance for the discrimination of mine water.
Structural analysis of Plasmodium falciparum ookinete surface antigen Pfs28 relevant for malaria vaccine design
Authors: Shukla Niharika , Tang Wai Kwan , Tolia Niraj H. 
Published: November 2022

AbstractPfs28 is a Plasmodium falciparum malaria transmission-blocking vaccine candidate that is anchored to the parasite surface through a C-terminal glycosylphosphatidylinositol (GPI) moiety, and plays a role in parasite survival in the mosquito midgut. Pfs28 contains epidermal growth factor (EGF)-like domains and is part of a family of sexual stage malaria proteins that includes the related vaccine antigen Pfs25. The lack of structural definition of Pfs28 and the immune response to this candidate has limited further malaria vaccine development for this antigen. Here, we present the crystal structure of Pfs28, examine its conservation with P. vivax Pvs28, and evaluate the cross-reactivity of Pfs28 to antibodies that recognize Pfs25. Pfs28 is comprised of four EGF-like domains stabilized by ten disulfide bridges with an overall architecture that highly resembles Pfs25. Despite the high sequence and structural similarity between these antigens, no cross reactivity of Pfs28 to anti-Pfs25 monoclonal antibodies could be demonstrated.
A new approach for microstructure imaging
Authors: Plancoulaine Benoît , Rasmusson Allan , Labbé Christophe , Levenson Richard , Laurinavicius Arvydas 
Published: November 2022

AbstractA recurring issue with microstructure studies is specimen lighting. In particular, microscope lighting must be deployed in such a way as to highlight biological elements without enhancing caustic effects and diffraction. We describe here a high frequency technique due to address this lighting issue. First, an extensive study is undertaken concerning asymptotic equations in order to identify the most promising algorithm for 3D microstructure analysis. Ultimately, models based on virtual light rays are discarded in favor of a model that considers the joint computation of phase and irradiance. This paper maintains the essential goal of the study concerning biological microstructures but offers several supplementary notes on computational details which provide perspectives on analyses of the arrangements of numerous objects in biological tissues.
Adaptive heading correction for an industrial heavy-duty omnidirectional robot
Authors: Galati Rocco , Mantriota Giacomo , Reina Giulio 
Published: November 2022

AbstractThe paper deals with the design and testing of a robot for industrial applications featuring omnidirectionality thanks to the use of mecanum wheels. While this architecture provides remarkable manoeuvrability in narrow or cluttered spaces, it has some drawbacks that limit its widespread deployment in practice, especially for heavy-duty and long-duration tasks. As an example, the variability in the mecanum wheel rolling radius leads to undesired dynamic ill-effects, such as slippage and vibrations that affect the accuracy of pose estimation and tracking control systems. Drawing on the modeling of the kinematic and dynamic behaviour of the robot, these effects have been tackled within an adaptive estimation framework that adjusts the robot control system based on the properties of the surface being traversed. The proposed approach has been validated in experimental tests using a physical prototype operating in real industrial settings.
Bolus Clearance Ratio Elevated in Patients With Neurogenic Dysphagia Compared With Healthy Adults: A Measure of Pharyngeal Efficiency
Authors: Leonard Rebecca , Miles Anna , Allen Jacqui 
Published: November 2022

Purpose:

Postswallow pharyngeal residue is a risk factor for aspiration, implies swallowing inefficiency, and increases the work of eating. The Bolus Clearance Ratio (BCR) is a derived metric that relates quantities of bolus material observed in the pharynx at two different points: before and after a swallow. The ratio provides a percentage estimate of bolus clearance. In healthy adults, mean BCR is < .05; that is, less than 5% of an ingested bolus is retained in the pharynx. The aim of this study was to compare BCR measures from patients referred for videofluoroscopic swallow studies with concerns related to stroke (
n
= 100) or other neurological conditions (
n
= 131, including Parkinson's disease and dementia) with BCRs for 139 healthy adults across the age range.

Method:
BCR for a 20 ml of thin liquid barium bolus was measured. Additional metrics included age, penetration–aspiration scale (PAS) score, and quantitative measures of timing and displacement. Correlations were explored between BCR and pharyngeal constriction ratio (PCR), pharyngoesophageal segment opening (PESmax), maximum hyoid displacement (HMax), and total pharyngeal transit time (TPT).

Results:

BCR values for patients with stroke (
Mdn
= 9%, interquartile range [IQR]: 19%, range: 0%–73%) and other neurological conditions (
Mdn
= 9%, IQR: 16%, range: 0%–96%) were significantly higher than in healthy norms (
Mdn
= 2%, IQR: 4%, range: 0%–16%,
p
< .001). BCR was significantly correlated with age (
R
s
= .23,
p
< .01), TPT (
R
s
= .20,
p
< .01), PCR (
R
s
= .55,
p
< .01), PESmax (
R
s
= −.17,
p
< .01), HMax (
R
s
= −.16,
p
< .01), and PAS (
R
s
= .38,
p
< .01).

Conclusions:
BCR was elevated in patients with neurogenic dysphagia in comparison with healthy norms and was significantly associated with increased aspiration severity (i.e., PAS). BCR was also correlated with pharyngeal timing and displacement parameters, with the strongest correlation with pharyngeal constriction—a measure of pharyngeal strength. The BCR offers clinicians a simple, quantitative measure of bolus residue and, therefore, pharyngeal efficiency and may be used to assess change in patients over time and with treatment.
The correlation between biotribological function and structural characteristics of bamboo rat teeth
Authors: Ning Zhenwu , Zhou Zhongrong , Zheng Jing 
Published: November 2022

AbstractChinese bamboo rats consume a diet that consists mainly mechanically demanding bamboo. The ability of the rats to process food depends on the capacity of their teeth to resist wear during biting and chewing. The mechanisms of the bamboo rat teeth were determined by investigating and correlating the structure and tribological properties of the teeth. The rat's incisor has a cutting‐edge cusp and outer enamel iron pigmentation, making the teeth harder, more resistant to acid attacks, and improving the resistance to cracking. Additionally, the incisor is designed to self‐sharpen. The complex morphology at the macroscale, and the three‐dimensional fabric body formed by densely packed rods and inter‐rods at the microscale of molar enamel benefit molar rapid capture and effective breaking of bamboo, resisting the high stresses required to process bamboo without wear. The results of the structure–function relations of bamboo rat teeth in this study may provide new ideas for improving plant cutting and grinding tools.
Design and cryptanalysis of a new iterative structure
Authors: Liu Jiajie , Sun Bing , Li Chao 
Published: November 2022

AbstractThis study proposes a new iterative structure called the L‐Feistel structure, which shares similar procedures between encryption and decryption and could unify the Feistel structure and the Lai‐Massey structure. This paper evaluates the security of the L‐Feistel structure from the perspective of provable security and classical analysis, respectively. Firstly, it is proved that the 4‐round Key‐Alternating L‐Feistel cipher with independent round keys and independent round functions is secure against 2n/2 queries that is, birthday‐bound security. Then by presenting the dual structure of the L‐Feistel structure with SP‐type round functions, it is proven that a differential of the L‐Feistel structure is impossible when and only when it is a zero‐correlation linear hull of its dual structure. Finally, the paper constructs impossible differentials, zero‐correlation linear hulls and integral distinguishers of the L‐Feistel structure with SP‐type round functions which cover six and seven rounds, respectively, under different conditions.