bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameters of Axion-Like Particles Required to Explain High-Energy Photons from GRB 221009A
Authors: Troitsky S. V. 
Published: November 2022

Recent astrophysical transient Swift J1913.1+1946 is possibly associated with the gamma-ray burst GRB 221009A at the redshift $$z \approx 0.151$$. The transient was accompanied by very high-energy gamma rays up to 18 TeV observed by LHAASO and a photon-like air shower of 251 TeV detected by Carpet-2. These energetic gamma rays cannot reach us from the claimed distance of the source because of the pair production on cosmic background radiation. If the identification and redshift measurements are correct, one would require new physics to explain the data. One possibility invokes axion-like particles (ALPs) which mix with photons but do not attenuate on the background radiation. Here we explore the ALP parameter space and find that the ALP–photon mixing in the Milky Way, and not in the intergalactic space, may help to explain the observations. However, given the low Galactic latitude of the event, misidentification with a Galactic transient remains an undiscarded explanation.
Cardiopulmonary fitness in children with asthma versus healthy children
Authors: Moreau Johan , Socchi Floriane , Renoux Marie Catherine , Requirand Anne , Abassi Hamouda , Guillaumont Sophie , Matecki Stefan , Huguet Helena , Avesani Martina , Picot Marie-Christine , Amedro Pascal 
Published: November 2022

ObjectivesTo evaluate, with a cardiopulmonary exercise test (CPET), the cardiopulmonary fitness of children with asthma, in comparison to healthy controls, and to identify the clinical and CPET parameters associated with the maximum oxygen uptake (VO2max) in childhood asthma.DesignThis cross-sectional controlled study was carried out in CPET laboratories from two tertiary care paediatric centres. The predictors of VO2maxwere determined using a multivariable analysis.ResultsA total of 446 children (144 in the asthma group and 302 healthy subjects) underwent a complete CPET. Mean VO2maxwas significantly lower in children with asthma than in controls (38.6±8.6 vs 43.5±7.5 mL/kg/min; absolute difference (abs. diff.) of −4.9 mL/kg/min; 95% CI of (−6.5 to −3.3) mL/kg/min; p<0.01) and represented 94%±9% and 107%±17% of predicted values, respectively (abs. diff. −13%; 95% CI (−17 to −9)%; p<0.01). The proportion of children with an impaired VO2maxwas four times higher in the asthma group (24% vs 6%, p<0.01). Impaired ventilatory efficiency with increased VE/VCO2slope and low breathing reserve (BR) were more marked in the asthma group. The proportion of children with a decreased ventilatory anaerobic threshold (VAT), indicative of physical deconditioning, was three times higher in the asthma group (31% vs 11%, p<0.01). Impaired VO2maxwas associated with female gender, high body mass index (BMI), FEV1, low VAT and high BR.ConclusionCardiopulmonary fitness in children with asthma was moderately but significantly altered compared with healthy children. A decreased VO2maxwas associated with female gender, high BMI and the pulmonary function.Trial registration numberNCT04650464.
EUS-guided drainage of large walled-off pancreatic necroses using plastic versus lumen-apposing metal stents: a single-centre randomised controlled trial
Authors: Karstensen John Gásdal , Novovic Srdan , Hansen Erik Feldager , Jensen Annette Bojer , Jorgensen Henrik Lovendahl , Lauritsen Morten Laksafoss , Werge Mikkel Parsberg , Schmidt Palle Nordblad 
Published: November 2022

ObjectiveIn treating pancreatic walled-off necrosis (WON), lumen-apposing metal stents (LAMS) have not proven superior to the traditional double pigtail technique (DPT). Among patients with large WON (>15 cm) and their associated substantial risk of treatment failure, the increased drainage capacity of a novel 20-mm LAMS might improve clinical outcomes. Hence, we conducted a study comparing the DPT and 20-mm LAMS in patients with large WON.DesignA single-centre, open-label, randomised, controlled superiority trial using an endoscopic step-up approach in patients with WON exceeding 15 cm in size. The primary endpoint was the number of necrosectomies needed to achieve clinical success (clinical and CT resolution), while the secondary endpoints included technical success, adverse events, length of stay and mortality.ResultsTwenty-two patients were included in the DPT group and 20 in the LAMS group, with no significant differences in patient characteristics. The median size of WON was 24.1 cm (P25–P75: 19.6–31.1). The technical success rates were 100% for DPT and 95% for LAMS (p=0.48), while clinical success rates were 95.5% and 94.7%, respectively (p=1.0). The mean number of necrosectomies was 2.2 for DPT and 3.2 for LAMS (p=0.42). Five patients (12%) developed procedure-related serious adverse events (DPT=4, LAMS=1, p=0.35). The median length of stay was 43 (P25–P75: 40–67) and 58 days (P25–P75: 40–86) in the DPT and LAMS groups (p=0.71), respectively, with an overall mortality of 4.8%.ConclusionsFor treating large WON, LAMS are not superior to DPT. The techniques are associated with comparable needs for necrosectomy and hospital stay, and no gross difference in adverse events.Trial registration numberNCT04057846.
Clinical and psychological implications of secondary and incidental findings in cancer susceptibility genes after exome sequencing in patients with rare disorders
Authors: Carrasco Estela , López-Fernández Adrià , Codina-Sola Marta , Valenzuela Irene , Cueto-González AM , Villacampa Guillermo , Navarro Victor , Torres-Esquius Sara , Palau Dolors , Cruellas Mara , Torres Maite , Perez-Dueñas Belen , Abulí Anna , Diez Orland , Sábado-Álvarez Constantino , García-Arumí Elena , Tizzano Eduardo F , Moreno Lucas , Balmaña Judith 
Published: November 2022

Background/ObjectivesExome sequencing may identify pathogenic variants unrelated with the purpose of the analysis. We investigated the frequency of secondary and incidental findings (SF/IF) in cancer susceptibility genes (CSG), their clinical actionability and the psychological impact in individuals with an SF/IF (cases) compared with individuals tested due to their cancer history (controls).MethodsThis study analysed 533 exomes ordered for non-cancer conditions. Medical records were reviewed for clinical actionability of SF/IF. Psychological impact was analysed using the Multidimensional Impact of Cancer Risk Assessment (MICRA) scale and compared between cases and controls with a propensity score weighting method.ResultsThe frequency of SF/IF in CSG was 2.1% (95% CI 1.1% to 3.8%): threeBRCA2, threePMS2, twoSDHB, and one each inBRCA1,MLH1andRAD51C. Among the relatives, 18 were carriers. Twenty enrolled for surveillance, and a neoplasm was diagnosed in 20%: three paragangliomas and one breast cancer. Cases presented higher MICRA mean scores than controls (21.3 vs 16.2 in MICRA total score, 6.3 vs 4.2 in the distress subscale, and 8.3 vs 6.6 in the uncertainty subscale; all p<0.001).ConclusionSF/IF in CSG were identified in 2.1% of patients. Despite a numerically higher psychological impact, the identification of SF/IF allowed early detection and cancer prevention in families without cancer history.
Should menthol e-cigarettes be banned? Reaction of adult smokers and users of e-cigarettes to hypothetical bans
Authors: Yang Yong , Lindblom Eric N , Ward Kenneth D , Salloum Ramzi G 
Published: November 2022

IntroductionThis study examines how current smokers using menthol cigarettes or flavoured cigars, and current users of flavoured e-cigarettes may respond to three hypothetical flavour-ban scenarios: (1) banning only menthol cigarettes and flavoured cigars; (2) also banning e-cigarettes with any non-tobacco flavours except menthol; and (3) also banning e-cigarettes with any non-tobacco flavours, including menthol.MethodsRecruited from mTurk, respondents were asked if they would quit all tobacco-nicotine use or continue or start using products that were still legally available. The patterns of responding to each ban scenario, for both flavoured smokers and users of non-tobacco flavoured e-cigarettes, were summarised. Multinomial logistic regressions were used to estimate associations between demographics, smoking or e-cigarette use status and reactions to a ban.ResultsA ban on menthol cigarettes and flavoured cigars would lead to 12%–20% of flavoured smokers trying to quit all tobacco use and 32%–52% switching to non-flavoured smoking, with the remaining switching to e-cigarettes or other products. Compared with a ban on only menthol cigarettes and flavoured cigars, also banning flavoured e-cigarettes would increase the likelihood of quitting all tobacco-nicotine use (OR=2.58) but also increase the likelihood of switching to non-flavoured smoking (OR=1.74).ConclusionsOur results indicate that a ban on menthol cigarettes and flavoured cigars would decrease smoking. However, it is unclear if adding a ban of menthol e-cigarettes would lead to additional benefits because without menthol e-cigarettes as an alternative, some smokers and e-cigarette users may switch to non-flavoured tobacco smoking, rather than quit all tobacco use.
ATP—Sensitive Potassium Channel Opener Diazoxide Reduces Myocardial Stunning in a Porcine Regional With Subsequent Global Ischemia Model
Authors: Velez Ana K. , Etchill Eric , Giuliano Katherine , Kearney Sean , Jones Melissa , Wang Jie , Cho Brian , Brady Mary Beth , Dodd‐o Jeffrey , Meyer Joseph M. , Lawton Jennifer S. 
Published: November 2022

Background
ATP‐sensitive potassium channels are inhibited by ATP and open during metabolic stress, providing endogenous myocardial protection. Pharmacologic opening of ATP potassium channels with diazoxide preserves myocardial function following prolonged global ischemia, making it an ideal candidate for use during cardiac surgery. We hypothesized that diazoxide would reduce myocardial stunning after regional ischemia with subsequent prolonged global ischemia, similar to the clinical situation of myocardial ischemia at the time of revascularization.

Methods and Results

Swine underwent left anterior descending occlusion (30 minutes), followed by 120 minutes global ischemia protected with hyperkalemic cardioplegia±diazoxide (N=6 each), every 20 minutes cardioplegia, then 60 minutes reperfusion. Cardiac output, time to wean from cardiopulmonary bypass, left ventricular (LV) function, caspase‐3, and infarct size were compared. Six animals in the diazoxide group separated from bypass by 30 minutes, whereas only 4 animals in the cardioplegia group separated. Diazoxide was associated with shorter but not significant time to wean from bypass (17.5 versus 27.0 minutes;
P
=0.13), higher, but not significant, cardiac output during reperfusion (2.9 versus 1.5 L/min at 30 minutes;
P
=0.05), and significantly higher left ventricular ejection fraction at 30 minutes (42.5 versus 15.8%;
P
<0.01). Linear mixed regression modeling demonstrated greater left ventricular developed pressure (
P
<0.01) and maximum change in ventricular pressure during isovolumetric contraction (
P
<0.01) in the diazoxide group at 30 minutes of reperfusion.

Conclusions
Diazoxide reduces myocardial stunning and facilitates separation from cardiopulmonary bypass in a model that mimics the clinical setting of ongoing myocardial ischemia before revascularization. Diazoxide has the potential to reduce myocardial stunning in the clinical setting.
Tragedy of the Non-Visible: Aesthetic and Ontological Differences in Early Computer versus Conceptual Art
Authors: Samuels Miranda 
Published: November 2022

AbstractThis article considers the complex relationship between early computer and Conceptual art in the late 1960s and early 1970s in the United States and Europe. It assesses a range of accounts that explain the simultaneous decline in art world support for computer art and growing institutional traction enjoyed by Conceptual art. The author argues that these accounts overlook a subtle but consequential difference in the aesthetic and ontological conditions of the two art forms. Comparative analysis of writings by computer and Conceptual artists and theorists ultimately shows that the relationship between the visible output and the non-visible code or algorithm in computer art is not akin to the relationship between materiality and immateriality in Conceptual art, as is oftentimes assumed. The paper suggests that historical accounts explaining the divergent trajectories of computer and Conceptual art address this difference to avoid oversimplifying computer art’s aesthetic and ontological conditions.
Age differences in functional brain networks associated with loneliness and empathy
Authors: Mwilambwe-Tshilobo Laetitia , Setton Roni , Bzdok Danilo , Turner Gary R. , Spreng R. Nathan 
Published: November 2022

Abstract
Loneliness is associated with differences in resting-state functional connectivity (RSFC) within and between large-scale networks in early- and middle-aged adult cohorts. However, age-related changes in associations between sociality and brain function into late adulthood are not well understood. Here, we examined age differences in the association between two dimensions of sociality—loneliness and empathic responding—and RSFC of the cerebral cortex. Self-report measures of loneliness and empathy were inversely related across the entire sample of younger (mean age = 22.6y, n = 128) and older (mean age = 69.0y, n = 92) adults. Using multivariate analyses of multi-echo fMRI RSFC, we identified distinct functional connectivity patterns for individual and age group differences associated with loneliness and empathic responding. Loneliness in young and empathy in both age groups was related to greater visual network integration with association networks (e.g., default, fronto-parietal control). In contrast, loneliness was positively related to within- and between-network integration of association networks for older adults. These results extend our previous findings in early- and middle-aged cohorts, demonstrating that brain systems associated with loneliness, as well as empathy, differ in older age. Further, the findings suggest that these two aspects of social experience engage different neurocognitive processes across human life-span development.
Diagnosing the State: Medical Metaphors in Ottoman Political Writing
Authors: Topal Alp Eren , Wigen Einar 
Published: November 2022

Abstract
This paper traces the transformation in how Ottoman scribes, statesmen, and bureaucrats imagined the body politic from the sixteenth to the nineteenth century by focusing on metaphors derived from medicine and the human body. As others have shown, sixteenth- and seventeenth-century Ottoman political writing demonstrates a clear influence of Galenic medicine and Aristotelian and Avicennan metaphysics in conceptualizing state and society. During the eighteenth century, however, we see the adoption of a Khaldunian conception of society as an organic unity with a determined lifespan, something that implies a shift in emphasis from spatiality to temporality of the polity. From the early Tanzimat onwards, we see sporadic use of modern medical, disease, and germ-related concepts to explain the problems of Ottoman politics and society. Our argument is that instead of a sudden shift from a Galenic to a modern medical vocabulary due to the impact of the West, Ottoman political imagery gradually changed over the seventeenth and eighteenth centuries in response to administrative challenges. In narrating this transformation, we also reflect on how examining metaphors can contribute to our understanding of conceptual transformation and, particularly in our case, the concept of “state”.
The making of Islamic reform (iṣlāḥ) in Colonial Algeria (1882–1938): Ibadi scholars, French officials and the conceptual foundations of modern Islamic studies
Authors: Jomier Augustin 
Published: November 2022

Abstract
Among the conceptual foundations on which scholars of modern Islam have built their narratives for decades, ideas such as “reform” and “reformism” have been singled out for charges of Eurocentricism and Orientalism. At the same time, research on early modern Islam leads us to question the specificities of these nineteenth and twentieth-century concepts. Building on this scholarship, this article examines the case of Algerian Ibadi reform (iṣlāḥ) in order to reassert the specificity of the early twentieth century as a moment when Islamic concepts acquired new meanings, but also as a moment of deep entanglements between Islamic and colonial knowledge production. It shows that a systematic understanding of iṣlāḥ as social and religious reform linked to the idea of progress developed only during the interwar period. It also demonstrates that the emic and etic uses of iṣlāḥ and “reform” developed together, a result of the confluence between modern Islamic scholarship and scholarship about Islam in the early twentieth-century Algerian colonial public sphere. Thus, the conceptual history of iṣlāḥ warns us against approaches that consider emic and etic categories bounded entities and invites us instead to unravel their complexities.
Tracing the Nationalisation of Millet in the Late Ottoman Period: A Conceptual History Approach
Authors: Dressler Markus 
Published: November 2022

Abstract
During its last century, the Ottoman Empire faced strong contestation of its political order, which had undergone radical changes that are generally discussed in relation to modernisation. Against this background, key social and political concepts in Ottoman Turkish shed old meanings and acquired new ones. This article examines the trajectory of the term millet in this period as a case study. Drawing on political and lexicographic texts from the Tanzimat era and afterwards, the article discusses the semantic shifts through which millet, traditionally closely related to din/religion, acquired connotations of a political community, not the least proto-national ones. This led to a polysemy that remained relatively stable until the end of the Ottoman era, when the political meaning of the term millet as “nation” gained dominance. This secularisation of the term reached its peak in the early Turkish republic, although the older, religious connotations of the term were never totally forgotten and are still evoked in conservative religious discourse.
Sexual Health, Morality and the Missionary Press in Britain and the South Pacific, 1795–1850
Authors: Tilson Kate 
Published: November 2022

Abstract
This article explores the London Missionary Society’s textual production on the South Pacific in the first half of the nineteenth century and argues that sexuality was connected to moral and physical understandings of health in missionary texts. This was due to the nature of missionary and indigenous entanglements in the South Pacific and the era’s burgeoning medical print network. The discussion builds on current debates on mission and the cultural underpinnings of the British empire through showcasing the processes involved in the making of missionary texts and colonial knowledge production from the South Pacific.
Becoming a People of Greater Hospitality
Authors: Francisco Jose Mario 
Published: November 2022

Abstract
Unlike some religious traditions elsewhere, Philippine Catholicism readily recognized the severity of the Covid-19 pandemic as described by medical science and public health protocols. Given this general perspective, it promoted communal worship online and inclusive feeding programs – practices integral to Catholicism and rooted in the local religious ethos. The defining characteristics of these practices during the pandemic invite critical inquiry on its theological foundations. The first provides greater accessibility to the ekklesia and interrogates therefore the traditional notion of Catholic belonging and identity. The second exemplifies a more inclusive framework for social ministry on account of the wide diversity of roles among those involved and its integration of charitable services with structural change. Thus both practices challenge Philippine Catholicism to become a people of greater hospitality.
Investigating the plant growth promoting and biocontrol potentiality of endophytic Streptomyces SP. SP5 against early blight in Solanum lycopersicum seedlings
Authors: Devi Sapna , Sharma Manish , Manhas Rajesh Kumari 
Published: November 2022

Abstract
Background
Early blight (EB), caused by Alternaria solani, is one of the alarming diseases that restrict tomato production globally. Existing cultural practices and fungicide applications are not enough to control early blight diseases. Therefore, the study aimed to isolate, identify, and characterize an endophytic Streptomyces exhibiting the potential to control early blight in tomato and also promote plant growth.

Results
From a Citrus jambhiri leaf, an endophytic Streptomyces sp. with antagonistic activity against Alternaria solani, Colletotrichum acutatum, Cladosporium herbarum, Alternaria brassicicola, Alternaria sp., Fusarium oxysporum and Fusarium sp. was isolated. It was identified as a Streptomyces sp. through 16S ribosomal DNA sequence analysis and designated as SP5. It also produced indole acetic acid which was confirmed by Salkowski reagent assay, TLC and HPLC analysis. Treatment of pathogen infected plants with Streptomyces sp. SP5 antagonists (culture cells/culture supernatant/solvent extract/ acetone precipitates) decreased the early blight disease incidence and significantly increased the various agronomic traits.

Conclusion
The present study concluded that Streptomyces sp. SP5 possessed antifungal activity against different fungal phytopathogens and had significant potential to control early blight disease and promote plant growth.
Comparative plastomes and phylogenetic analysis of seven Korean endemic Saussurea (Asteraceae)
Authors: Yun Seona , Kim Seung-Chul 
Published: November 2022

Abstract
Background
Saussurea is one of the most species-rich genera in the Cardueae, Asteraceae. There are approximately 40 Saussurea species distributed in Korea, with nearly 40% of them endemics. Infrageneric relationships remain uncertain due to insufficient resolutions and low statistical support. In this study, we sequenced the plastid genomes of five Korean endemic Saussurea (S. albifolia, S. calcicola, S. diamantica, S. grandicapitula, and S. seoulensis), and comparative analyses including two other endemics (S. chabyoungsanica and S. polylepis) were conducted.

Results
The plastomes of Korean endemics were highly conserved in gene content, order, and numbers. Exceptionally, S. diamantica had mitochondrial DNA sequences including two tRNAs in SSC region. There were no significant differences of the type and numbers of SSRs among the seven Korean endemics except in S. seoulensis. Nine mutation hotspots with high nucleotide diversity value (Pi > 0.0033) were identified, and phylogenetic analysis suggested that those Korean endemic species most likely evolved several times from diverse lineages within the genus. Moreover, molecular dating estimated that the Korean endemic species diverged since the late Miocene.

Conclusions
This study provides insight into understanding the plastome evolution and evolutionary relationships of highly complex species of Saussurea in Korean peninsula.