bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Anterior Segment Abnormalities in Individuals With FOXC1 and PITX2 Variants
Authors: Prem Senthil Mallika , Knight Lachlan S. W. , Taranath Deepa , Mackey David A. , Ruddle Jonathan B. , Chiang Mark Y. , Siggs Owen M. , Souzeau Emmanuelle , Craig Jamie E. 
Published: March 2022

Purpose:
Axenfeld–Rieger syndrome encompasses a group of developmental disorders affecting the anterior chamber structures of the eye, with associated systemic features in some cases. This study aims to compare the difference in anterior segment phenotypes such as those involving the cornea, iris, lens, and anterior chamber angle between cases with disease-causing sequence variations in FOXC1 and PITX2.

Methods:
This cross-sectional study involved 61 individuals, from 32 families with pathogenic FOXC1 or PITX2 variants, who were registered with the Australian and New Zealand Registry of Advanced Glaucoma.

Results:
The median age of the cohort was 39 years at the time of last assessment (range 3–85 years; females, 54%). Thirty-two patients had pathogenic variants in the FOXC1 gene, and 29 patients had pathogenic variants in the PITX2 gene. Corneal abnormalities were more common in individuals with FOXC1 variants (18/36, 50%) than those with PITX2 variants (4/25, 16%; P = 0.007). Iris abnormalities such as hypoplasia (P = 0.008) and pseudopolycoria (P = 0.001) were more common in individuals with PITX2 variants than those with FOXC1 variants. Glaucoma was present in 72% of participants. Corneal decompensation was positively associated with corneal abnormalities (P < 0.001), glaucoma surgery (P = 0.025), and cataract surgery (P = 0.002).

Conclusions:
Corneal abnormalities were more common in individuals with FOXC1 than in those with PITX2 variants and were often associated with early onset glaucoma. These findings highlight that patients with FOXC1 variations require close follow-up and monitoring throughout infancy and into adulthood.
Age-based disparities in telehealth use in an urban, underserved population in cancer and pulmonary clinics: A need for policy change
Authors: Pasquinelli Mary M. , Patel Darshil , Nguyen Ryan , Fathi Joelle , Khan Mahir , Fernandez Katia , Bhatia Yash , Corbridge Susan , Cadman Kasandra , Harmon Vanessa , Trosman Julia , Weldon Christine , Pappalardo Andrea A. , Nyenhuis Sharmilee M. 
Published: March 2022

ABSTRACT

Background:
During the COVID-19 pandemic, telehealth rapidly emerged as an essential health care service and became particularly important for patients with cancer and chronic conditions. However, the benefits of telehealth have not been fully realized for some of the most vulnerable populations due to inequitable access to telehealth capable technology.

Purpose:
This study aimed to assess accessibility and satisfaction with telehealth technology by vulnerable patients with cancer and pulmonary disease.

Methodology:
A paper survey and internet-based survey were developed and administered to adult (≥18 years) cancer and pulmonary clinic patients (July 1, 2020 to October 30, 2020).

Results:
Descriptive statistics and Fisher exact test were performed. Two hundred eleven patients completed the survey. Adults ≥50 years old (older) had reduced access to smartphone video capability and internet connection compared with adults less than 50 years old (59% vs. 90%, p < .01). Older adults reported more challenges with telehealth visits compared with younger adults (50.3%, 28.6%; p < .01). No difference in access to technology and preferences for telehealth versus in-person care was found by race, gender, or education level.

Conclusions:
Nearly all patients (95%) who had a previous experience with a telehealth visit felt confident in the quality of care they received via telehealth. Younger adults preferred video visits compared with older adults (75% vs. 50.6%, p < .01). Older adults were less likely to have access to smartphones with internet access, have more challenges with telehealth visits, and were less likely to prefer audio–video telehealth visits compared with younger adults.

Implications:
Ensuring equitable access to all health care delivery modalities by telehealth, including audio-only visits for patients across the age continuum, is paramount.
BMI is important in predicting the loss of response in inflammatory bowel disease patients on tumour necrosis factor-α inhibitors
Authors: Chuck Winnie , Shadbolt Bruce Frederick , Nordin Fariza , Subramaniam Kavitha 
Published: March 2022

Introduction
Obesity is an emerging phenomenon among patients with inflammatory bowel disease (IBD). This study aims to evaluate whether the response to tumour necrosis factor-α (TNF-α) inhibitors (infliximab and adalimumab) could be influenced by BMI in IBD.

Methods
We identified a cohort of 181 IBD patients attending a single-tertiary centre, naive to biologic therapy and stratified them according to their BMI. The primary outcome is the first occurrence of loss of response (LOR).

Results
The median BMI was 26 kg/m2 (15–63 kg/m2). Approximately 68% of patients had LOR on both adalimumab (ADA) (n = 52) and infliximab (IFX) (n = 71). However, 83% on ADA with BMI ≥30 kg/m2 had LOR compared to 61% on IFX with BMI ≥30 kg/m2. For patients on ADA, Cox regression analysis revealed that after accounting for age, sex, disease type, duration of disease, fistulising disease, smoking status, haemoglobin, C-reactive protein, albumin and platelet levels, there were statistically significant associations between BMI (≥30 kg/m2 vs. <30 kg/m2) and LOR [P = 0.010; hazard ratio (HR) 3.2; confidence interval (CI), 1.3–7.6]. However, for patients on IFX, after accounting for the same factors, the only significant factor was the association of lower rate of LOR with higher albumin levels (P = 0.024; HR 0.95; CI, 0.91–0.99). There was an increased accelerated time to LOR for patients on ADA with BMI ≥30 kg/m2 compared to BMI <30 kg/m2 (P = 0.026). However, there was no difference in time to LOR for patients on IFX (P = 0.177).

Conclusion
BMI is important in predicting the LOR among IBD patients on TNF-α inhibitors, especially among patients receiving ADA.
The Association Between Binge-Watching Behavior and Psychological Problems Among Adolescents
Authors: Özkent Yasemin , Açıkel Burak 
Published: March 2022

Abstract
This study aims to investigate the relationship between binge-watching addiction and family, emotional, conduct, cognitive and anger control problems, hyperactivity, Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV)–ADHD Index, DSM-IV–Inattention, and DSM-IV–Hyperactivity Impulsivity in a large sample of healthy Turkish adolescents. The association between binge-watching behavior addiction and mood disorders in healthy adolescents was examined in this cross-sectional study conducted in Turkey. Participants completed both measures, The Binge-Watching Addiction Questionnaire and The Conners-Wells’ Adolescent Self-Report Scale. An online survey of 189 adolescents was conducted. One hundred fourteen subjects (60.3%) were categorized into the binge-watcher group. Results showed important positive associations between binge-watching behavior and emotional, conduct, cognitive problems, and DSM-IV–Inattention. The conducted analysis showed an important association between high frequency of binge-watching and emotional problems (p < 0.001), conduct problems (p = 0.012), cognitive problems (p = 0.001), and inattention (p < 0.001). These findings contributed to our comprehension of adolescents’ psychological correlates of television viewing behavior. Further researches on the relationship between extreme binge-watching and psychiatric disorders of adolescents are recommended.
A Clinical Prediction Model Based on Post Large Artery Atherosclerosis Infarction Pneumonia
Authors: Zhang Wen-Bo , Tang Tian-Chi , Zhang An-Ke , Zhang Zhong-Yuan , Hu Qiu-Si , Shen Zhi-Peng , Chen Zhi-Lin 
Published: March 2022

Background and Purpose:
Stroke-associated pneumonia (SAP) has been found as a common complication in acute ischemic stroke (AIS) patients. Large artery atherosclerosis (LAA) infarct is a major subtype of AIS. This study aimed to build a clinical prediction model for SAP of LAA type AIS patients.

Methods:
This study included 295 patients with LAA type AIS. Univariate analyses and logistic regression analyses were conducted to determine the independent predictors for the modeling purpose. Nomogram used receiver operating characteristics to assess the accuracy of the model, and the calibration plots were employed to assess the fitting degree between the model and the practical scenario. One hundred and five patients were employed for the external validation to test the stability of the model.

Results:
From the univariate analysis, patients’ ages, neutrophil-to-lymphocyte ratios, National Institute of Health Stroke scale (NIHSS) scores, red blood cell, sex, history of coronary artery disease, stroke location and volume-viscosity swallow test showed statistical difference in the development group for the occurrence of SAP. By incorporating the factors above into a multivariate logistic regression analysis, patients’ ages, neutrophil-to-lymphocyte ratios, NIHSS, and volume-viscosity swallow test emerged as the independent risk factors of the development of SAP. The nomogram based on the mentioned 4 variables above achieved a receiver operating characteristic of 0.951 and a validation group of 0.946.

Conclusions:
The proposed nomogram is capable of predicting predict the occurrence of SAP in LAA type AIS patients, and it may identify high-risk patients in time and present information for in-depth treatment.
Variants of Th17 pathway-related genes influence brain morphometric changes and the risk of schizophrenia through epistatic interactions
Authors: Subbanna Manjula , Shivakumar Venkataram , Bhalerao Gaurav , Varambally Shivarama , Venkatasubramanian Ganesan , Debnath Monojit 
Published: March 2022

Objective
T helper 17 (Th17) pathway has been reported to be abnormal in schizophrenia; however, it is not known whether variation within genes of this pathway has any impact on schizophrenia. Herein, the impact of genetic variations and gene–gene interactions of Th17 pathway-related genes on the risk, psychopathology, and brain volume was examined in schizophrenia patients.

Methods
Functional polymorphisms within interleukin 6 (IL6)(rs1800795 and rs1800797), IL10 (rs1800872 and rs1800896), IL17A (rs2275913 and rs8193036), IL22 (rs2227484 and rs2227485), IL23R (rs1884444), and IL27 (rs153109 and rs181206) genes were studied in 224 schizophrenia patients and 226 healthy controls. These variants were correlated with the brain morphometry, analyzed using MRI in a subset of patients (n = 117) and controls (n = 137).

Results
Patients carrying CC genotype of rs2227484 of IL22 gene had significantly higher apathy total score [F (1,183) = 5.60; P = 0.019; partial ɳ2 = 0.030]. Significant epistatic interactions between IL6 (rs1800797) and IL17A (rs2275913) genes were observed in schizophrenia patients. GG genotype of rs2275913 of IL17A gene was associated with reduced right middle occipital gyrus volume in schizophrenia patients (T = 4.56; P < 0.001).

Conclusion
Interactions between genes of Th17 pathway impact the risk for schizophrenia. The variants of Th17 pathway-related genes seem to have a determining effect on psychopathology and brain morphometric changes in schizophrenia.
Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones
Authors: Lima Noemia S. , Musayev Maryam , Johnston Timothy S. , Wagner Danielle A. , Henry Amy R. , Wang Lingshu , Yang Eun Sung , Zhang Yi , Birungi Kevina , Black Walker P. , O’Dell Sijy , Schmidt Stephen D. , Moon Damee , Lorang Cynthia G. , Zhao Bingchun , Chen Man , Boswell Kristin L. , Roberts-Torres Jesmine , Davis Rachel L. , Peyton Lowrey , Narpala Sandeep R. , O’Connell Sarah , Wang Jennifer , Schrager Alexander , Talana Chloe Adrienna , Leung Kwanyee , Shi Wei , Khashab Rawan , Biber Asaf , Zilberman Tal , Rhein Joshua , Vetter Sara , Ahmed Afeefa , Novik Laura , Widge Alicia , Gordon Ingelise , Guech Mercy , Teng I-Ting , Phung Emily , Ruckwardt Tracy J. , Pegu Amarendra , Misasi John , Doria-Rose Nicole A. , Gaudinski Martin , Koup Richard A. , Kwong Peter D. , McDermott Adrian B. , Amit Sharon , Schacker Timothy W. , Levy Itzchak , Mascola John R. , Sullivan Nancy J. , Schramm Chaim A. , Douek Daniel C. 
Published: March 2022

AbstractAn important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. The basis for such cross-protection at the molecular level is incompletely understood. Here we characterized the repertoire and epitope specificity of antibodies elicited by Beta, Gamma and ancestral variant infection and assessed their cross-reactivity to these and the more recent Delta and Omicron variants. We developed a high-throughput approach to obtain immunoglobulin sequences and produce monoclonal antibodies for functional assessment from single B cells. Infection with any variant elicited similar cross-binding antibody responses exhibiting a remarkably conserved hierarchy of epitope immunodominance. Furthermore, convergent V gene usage and similar public B cell clones were elicited regardless of infecting variant. These convergent responses despite antigenic variation may represent a general immunological principle that accounts for the continued efficacy of vaccines based on a single ancestral variant.
Impact of working capital management on firm profitability and liquidity: the moderating role of family ownership
Authors: Abdullah Abdullah , Hashmi Muhammad Arsalan , Iqbal Muhammad Sikander 
Published: March 2022

PurposeThis study aims to analyze whether family ownership and working capital management (WCM) affect firm profitability and liquidity. Further, we also investigate the moderating effect of family ownership on the association between WCM, firm profitability and liquidity.Design/methodology/approachThis study uses a sample of 150 nonfinancial companies listed on the Pakistan Stock Exchange for the period 2014–2019. For empirical analysis, this study used multiple proxies of family ownership and applied robust and bootstrapped quantile regression models.FindingsThe results suggest that family ownership has a negative association with firm profitability and liquidity. Moreover, this study finds a positive association between WCM and firm profitability and liquidity. Furthermore, the results indicate that family ownership negatively moderates the association between WCM and firm profitability. In addition, we argue that family ownership rescinds the impact of WCM as excess liquidity may be used for extracting private benefits and related party transactions.Originality/valueFirst, this study has examined the nexus between family ownership, WCM, firm profitability and liquidity in the context of a developing country, i.e. Pakistan. Second, previous studies have not analyzed the moderating role of family ownership in the association between working capital management, firm profitability and liquidity. Third, this study provides unique evidence that family-owned firms have an adverse liquidity position as compared with other firms.
Spiraling impact of discrepancies in sales accounting on a booming business: a case study of T.M. Exports
Authors: Faridi Mohammad Rishad , Ahmad Mubeen 
Published: March 2022

Learning Outcomes
By reading and understanding this case study, students are expected to: 1.Able to understand and review the impact of unethical practices from accounting perspective; 2.Able to make an analysis of how one unethical act triggers a series of forced unethical acts (ripple effect); 3.Identify the unfair practices as well as be proactive in preventing unfair practices in the business day to day affairs; 4.Able to relate the function of various ratios (current ratio, quick ration, debt to asset ratio, debt to equity ratio etc.) and its impact on the business performance; and 5.Able to apply various lean quality tools, doing the root cause analysis in identifying and solving problems.

Case Overview/Synopsis
T.M. Exports (TME) was an India-based privately owned and operated enterprise. The company had a brilliant employee named Sanjay, who was a 12-year veteran. TME’s Business Intelligence (BI) department at TME head office, Kanpur, India, ostensibly learned on April 8, 2019, from the rumors about a brand-new vehicle dished out to Sanjay by his friend who made fortune worth of millions from certain transactions. To add fuel to the fire, another incident surfaced concerning a warehouse keeper, Mohit, who was also involved in embezzlement in one of the sales offices. On May 16, 2019, BI reported these two incidents to the internal auditor who launched an internal investigation to get to root of this case. Consequently, the company owner, Tariq Mahmood got himself caught up in a dilemma to fire both Sanjay and Mohit only or restructure the organization for better transparency and integrative approach in future. Moreover, the newly appointed Chief Executive Officer had the dilemma of keeping high safety stock to maximize service level or keeping conservative safety stock and rely on-spot market-buying if demand spiked. He decided and instructed all the warehouses to keep higher inventories to meet the forecasted demand, considering unexpected spikes in demand witnessed historically. Thus, increase in inventory caused panic in the sales department as demand was sluggish. He, therefore, offered high discounted prices to liquidate the stock. This study integrated the theories of accounting/financial ratio metrics, accounts reconciliation, business ethics and lean tools. It was demonstrated in this case that the irregularities in sales accounting and their inability of reconciliation had a serious impact on business performance. The concept of total reward was also invoked to understand the disruptive and unscrupulous practices.

Complexity Academic Level
This case has been particularly focused on undergraduate and postgraduate early-stage-level students pursuing business or commerce program, particularly those specializing in accounting (sales accounting) and human resource management courses.

Supplementary materials
Teaching notes are available for educators only.

Subject Code
CSS 1: Accounting and Finance.
The influence of clan culture and supervisor support on Korean female managers’ subjective career success: mediating role of leadership competencies
Authors: Yim Suwon , Kim Minyoung , Park Yoonhee 
Published: March 2022

PurposeThe purpose of this study is to investigate the structural relationships between clan culture, perceived supervisor support, leadership competencies and subjective career success among South Korean female managers.Design/methodology/approachA structural equation modeling was used to analyze the sixth wave of data from the Korean Women Manager Panel (KWMP) survey by the Korean Women’s Development Institute in South Korea. The panel respondents were 1,384 female managers in tenured positions at South Korean companies.FindingsThe results showed that clan culture and perceived supervisor support directly influenced female managers’ subjective career success and indirectly affected their subjective career success through leadership competencies at the same time.Research limitations/implicationsThe respondents’ self-report can be a limitation as it can result in inflated outcomes in research findings. Even though no common method bias was found using Harmans’ single-factor test, the bias might not be removed completely. The study’s limitation includes the panel data and measures from KWMP, which constrained attempts to create constructs for measuring variables more precisely.Originality/valueThere is little research on the relationships between leadership competencies and other variables of female managers. The current study expanded the research on female managers’ leadership competencies by verifying that the leadership competencies play an important role in the relationships between clan culture, perceived supervisor support and subjective career success. The findings highlight that it is essential for female managers in South Korea to have supportive environments to receive fair treatment, demonstrate leadership competence in organizations and perform challenging tasks.
Fake news on the internet: a literature review, synthesis and directions for future research
Authors: Wu Yuanyuan , Ngai Eric W.T. , Wu Pengkun , Wu Chong 
Published: March 2022

PurposeThe extensive distribution of fake news on the internet (FNI) has significantly affected many lives. Although numerous studies have recently been conducted on this topic, few have helped us to systematically understand the antecedents and consequences of FNI. This study contributes to the understanding of FNI and guides future research.Design/methodology/approachDrawing on the input–process–output framework, this study reviews 202 relevant articles to examine the extent to which the antecedents and consequences of FNI have been investigated. It proposes a conceptual framework and poses future research questions.FindingsFirst, it examines the “what”, “why”, “who”, “when”, “where” and “how” of creating FNI. Second, it analyses the spread features of FNI and the factors that affect the spread of FNI. Third, it investigates the consequences of FNI in the political, social, scientific, health, business, media and journalism fields.Originality/valueThe extant reviews on FNI mainly focus on the interventions or detection of FNI, and a few analyse the antecedents and consequences of FNI in specific fields. This study helps readers to synthetically understand the antecedents and consequences of FNI in all fields. This study is among the first to summarise the conceptual framework for FNI research, including the basic relevant theoretical foundations, research methodologies and public datasets.
Frontline service employees and customer engagement: some further insights
Authors: Zahoor Adil , Khan Danish 
Published: March 2022

PurposeThis study aims to investigate whether frontline retail banking employees’ proactive personality helps in ameliorating customer engagement. This study further aims to investigate the mediational role of work engagement and service recovery performance in the employee proactivity – customer engagement relationship.Design/methodology/approachThis study used a triadic approach for the collection of primary data. Each triad consisted of a customer, a frontline employee and an immediate colleague of the frontline employee. Structured questionnaires were used to solicit data from the respondents. Specifically, customers were asked to report their level of engagement with the bank and the recovery performance of the employee who redressed their grievances. Frontline employees responded to their level of work engagement while their colleagues reported about the proactive disposition of frontline employees at the workplace.FindingsEmpirical findings revealed under service scenario, Indian retail banking employees’ proactive disposition nurtures customer engagement. It was further observed that this relationship is sequentially mediated by work engagement and service recovery performance.Originality/valueThe role of frontline employees in enriching customer engagement has to date remained under-researched among marketing scholars. To the best of the authors’ knowledge, this study is the maiden attempt to relate frontline employee proactivity with customer engagement. Also, this study is one of the early research to investigate customer engagement under a service recovery context, thereby, opening pathways for further exploration.