bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived performances of peer learning and education approach on malaria prevention through primary schools communities in rural Ethiopia: Peer educators' perspectives
Authors: Deressa Alemayehu , Eyeberu Addis , Gamachu Mulugeta , Debella Adera , Abamecha Ababulgu Fira 
Published: November 2022

BackgroundSchools are viewed as natural hubs and an effective strategy for promoting community healthy practices such as malaria prevention and control. This study examined the perceived performance of the peer learning and education approach to malaria prevention in rural primary school communities in Ethiopia, which has thus far received little attention.MethodsPost-intervention data were collected from 404 randomly selected peer educators between 2 April and June 2020 using a structured questionnaire. The data were analyzed using the Statistical Package for Social Sciences (SPSS) version 24.0. Multiple linear regression was used to identify independent predictors of perceived performance of school-based peer learning and educational approach. A statistically significant p-value of &lt; 0.05 was considered statistically significant.ResultsFour hundred and one educators (99.2%) completed the interview. The mean score of perceived performance was 44.31 (SD = 6.13) which was above the expected mean level range of 11–55. Feasibility (β = 0.253, 95% CI = [0.313, 0.682]), and appropriateness (β = 0.163, 95% CI = [0.099, 0.442]) were significantly associated with perceived performance. Self-efficacy, malaria risk perception, eagerness to share and learn from each other's experiences, and preference for more than one subject were all significantly associated with perceived performance, with (β = 0.097, CI = [0.017, 0.242]), (β = 0.143, CI = [0.071, 0.233]), (β = 0.207, CI = [0.308, 0.826]) and (β = 0.075, CI = [0.084, 2.511]) at 95% CI, respectively.ConclusionsThe peer learning and education approach to malaria prevention and control in schools has a noticeably high level of perceived performance. Thus, it is recommended that when designing and implementing such programs through schools, personal and social (team) factors such as self-efficacy, risk perceptions, and peer education team spirit be considered.
Observation-based temperature field simulation at Zhurong landing site, Mars
Authors: Zhang Lei , Zhang Jinhai 
Published: November 2022

Modeling the temperature field near the Martian surface is critical for many scientific exploration tasks, such as detecting liquid water and analyzing the existence of saline ice. Meteorological conditions on Mars are highly dramatic, with a daily temperature change of up to 80–100 K. Most previous tasks of surface temperature monitoring on Mars are based on satellite observations, lacking in-situ measured data. Recently, two Martian missions at mid-low latitudes in the northern hemisphere, InSight lander and Zhurong rover, carried out near-surface temperature observations. However, the temperature monitoring of the Zhurong rover obtained data for only some short periods in its working days; thus, the amount of recorded temperature data is inadequate for a whole-day analysis at the landing site. Here we reconstruct the near-surface temperature at the Zhurong landing site by incorporating the continuous temperature data observed at the InSight lander, simultaneously referring to the Martian Climate Database; then, the reconstructed data are used to constrain the numerical simulation of the response of shallow subsurface under the Zhurong landing site. The numerical simulation of heat conduction shows that the daily temperature change under the Zhurong landing site mainly influences the uppermost depth of 0–30 cm, with a daily average temperature of ∼225 K. During the traveling duration of the Zhurong rover (i.e., summer of Mars), the seasonal temperature change within the top 1 m is significant and is related to the thermal properties of possible subsurface media (e.g., soil, ice, and sandstones). Although there might be aqueous activities in Utopia Planitia, our results show that from the perspective of temperature field, there is little possibility of liquid water in the shallow subsurface under the Zhurong landing site. The proposed method in this study provides a new way for the temperature field simulation of the subsurface in areas with insufficient local observations, especially on extraterrestrial objects.
Analysis of appendicitis management during COVID-19 pandemic: A study of Chinese adult cohorts
Authors: Wang Wei-Di , Lin Jin-Quan , Zheng Guang-Wei , Fang Zhi-Peng , Yan Yi-Xing 
Published: November 2022

BackgroundHealthcare seeking behavior has been widely impacted due to the restricted movements of individuals during the Coronavirus disease-19 (COVID-19) pandemic. This study aims to perform risk stratification in patients requiring timely intervention during the recovery periods.MethodsOperation notes of acute appendicitis (AA) patients within a hospital were analyzed during three six-month periods (23 January-23 July in 2019, 2020, and 2021, respectively). Patient data were collected retrospectively including demographics, pre-emergency status, perioperative information, postoperative outcomes, and follow-up results.Results321 patients were included in this study, with 111, 86, and 124 patients in 2019, 2020, and 2021 groups, respectively. The median age of patients decreased by 4 years in 2020 as compared to that in 2019. The proportion of pre-hospitalization symptoms duration of more than 48 h in the 2020 group was higher (36.05% in 2020 vs. 22.52% in 2019). Length of hospital stay (LOS) in 2020 was shorter than it was during the same period in 2019 (4.77 vs. 5.64) and LOS in 2021 was shorter than in 2019 (4.13 vs. 5.64). Compared to the lockdown period, the proportion of patients with recurrent AA was higher in the post-lockdown period (15.1% vs. 27.4%). The median age was 34 years (vaccinated) vs. 37 years (unvaccinated). Logistic regression suggests that elevated C-reactive protein (CRP) (OR = 1.018, CI = 1.010–1.028), white cell count (WBC) (OR = 1.207, CI = 1.079–1.350), female (OR = 2.958, CI = 1.286–6.802), recurrent (OR = 3.865, CI = 1.149–12.997), and fecalith (OR = 2.308, CI = 1.007–5.289) were associated with complicated appendicitis (CA).ConclusionThe lockdown measures during the COVID-19 epidemic are shown to be correlated with a reduction in the proportion of AA patients who underwent surgery, particularly in older adults. Risk factors for CA include elevated CRP, WBC, female, recurrent, and fecalith.
Three Pairs of Novel Enantiomeric 8-O-4′ Type Neolignans from Saussurea medusa and Their Anti-inflammatory Effects In Vitro
Authors: Cao Jing-Ya , Dong Qi , Wang Zhi-Yao , Mei Li-Juan , Tao Yan-Duo , Yu Rui-Tao 
Published: November 2022

Three pairs of novel enantiomeric 8-O-4′ type neolignans (1a/1b–3a/3b), together with seven known analogues (4–10), were isolated from the whole plants of Saussurea medusa. Their structures were elucidated by extensive spectroscopic data analysis and electric circular dichroism (ECD) calculations after chiral separations. All compounds were obtained from S. medusa for the first time, and compounds 1–3 and 5–10 had never been obtained from the genus Saussurea previously. The anti-inflammatory activities of the compounds were evaluated by determining their inhibitory activities on the production of NO and inducible nitric oxide synthase (iNOS) expression in LPS-stimulated RAW 264.7 cells. Compounds (+)-1a, (−)-1b and 5–7 inhibited NO production and had IC50 values ranging from 14.3 ± 1.6 to 41.4 ± 3.1 μM. Compound 7 induced a dose-dependent reduction in the expression of iNOS in LPS-treated RAW 264.7 cells. Molecular docking experiments showed that all active compounds exhibited excellent docking scores (<−7.0 kcal/mol) with iNOS. Therefore, compounds (+)-1a, (−)-1b and 5–7 isolated from the whole plants of S. medusa may have therapeutic potential in inflammatory diseases.
Clinical Outcomes of Single Versus Double Plating in Distal-Third Humeral Fractures Caused by Arm Wrestling: A Retrospective Analysis
Authors: Mao Jui-Ting , Chang Hao-Wei , Lin Tsung-Li , Lin I-Hao , Lin Chia-Yu , Hsu Chin-Jung 
Published: November 2022

Background and Objectives: Arm wrestling is a simple and popular activity among young people that causes distal-third humeral fractures. However, injury to the young population may cause economic loss; therefore, they need to return to work as soon as possible. Accordingly, we aimed to compare radiological and functional outcomes of distal-third humeral fractures caused by arm wrestling treated with double and single plating. Materials and Methods: Thirty-four patients with distal-third humeral fractures caused by arm wrestling were treated between January 2015 and January 2021. They were separated into double- and single-plating groups and treated using a triceps-sparing approach. Regular follow-up was performed to evaluate elbow functionality, range of motion, bone union, and complications; the American Shoulder and Elbow Surgeons score was used for functional assessment. Results: Patients treated with single plating exhibited union rate, union time, and elbow range of motion similar to those of patients treated with double plating; however, they exhibited better pain and functional outcomes (American Shoulder and Elbow Surgeons score) at 2 weeks, 1 month, and 3 months postoperatively (84.50 ± 5.01 vs. 61.70 ± 12.53 at 2 weeks, 96.20 ± 2.63 vs. 84.25 ± 14.56 at 1 month, and 100.00 vs. 94.76 ± 9.71 at 3 months, p < 0.05). The two groups exhibited no significant differences after 1 year (100.00 vs. 98.54 ± 3.99, p < 0.13). The overall complication rate was significantly higher in patients treated with double plating than in those treated with single plating (18.75% vs. 5.56%). Radial nerve palsy was observed in patients in both groups. Conclusions: In patients with distal-third humeral fractures caused by arm wrestling, single plating provides a union rate and elbow range of motion similar to those of double plating, with significantly fewer complications and lower surgical time and blood loss with improved early functional outcomes.
IDENTIFICATION AND DISTRIBUTION OF THE HH7 FERTILITY HAPLOTYPE OF HOLSTEIN CATTLE IN A SUBPOPULATION OF THE KRASNODAR TERRITORY
Authors: КОВАЛЮК Н.В. , ВОЛЧЕНКО А.Е. , ЯКУШЕВА Л.И. , ШАХНАЗАРОВА Ю.Ю. 
Published: November 2022

В 2020 году методом идентификации регионов с потерей гомозиготности открыт новый гаплотип крупного рогатого скота голштинской породы. Делеция (выпадение 4-х пар нуклеотидов) затрагивает ген CENPU(хромосома 27 g.14168130_14168133delTACT), онавлияет на высококонсервативную область генома млекопитающих. В гетерозиготном состоянии делецияприводит к носительству гаплотипа НН7, в гомозиготном — вызывает замедление роста эмбриона и самопроизвольный аборт. Родоначальниками этой аномалии считают голштинских производителей SECRET (HOLUSAM000001856904, 1980 г.р.), MERDRIGNAC (HOLFRAM002296001756, 1996 г.р.) и DUTCH BOY (HOLUSAM000017058140, 1996 г.р.). Частота встречаемости носителей НН7-гаплотипа в современной голштинской популяции составляет около 1,1%. Установлено, что среди коров и быков-производителей голштинской породы, используемых в системе искусственного осеменения в Краснодарском крае, носители гаплотипа НН7 отсутствуют. В статье приведены последовательности праймеров и методика генотипирования. Проблема распространения носительства гаплотипа НН7 для молочного скотоводства Краснодарского края в настоящее время не является актуальной. Однако тестирование на наличие гаплотипа НН7 желательно включить вместе с тестированием на наличие других гаплотипов голштинского скота (НН1, НН2, НН3, НН4, НН5, НСD) в список обязательных генетических исследований быков-производителей с целью не допустить в дальнейшем распространения мутации в гене CENPU.
In 2020, a new haplotype of Holstein cattle was discovered by identifying regions with loss of homozygosity. Deletion (loss of 4 nucleotide pairs) affects the CENPU gene (Chromosome 27 g.14168130_14168133delTACT), it affects a highly conserved region of the mammalian genome. In the heterozygous state, deletion leads to the carriage of the haplotype HH7, in the homozygous state, it causes a slowdown in embryo growth and spontaneous abortion. Holstein producers SECRET (HOLUSAM000001856904, born in 1980), MERDRIGNAC (HOLFRAM002296001756, born in 1996) and DUTCH BOY (HOLUSAM000017058140, born in 1996) are considered the originators of this anomaly. The frequency of occurrence of carriers of the HH7 haplotype in the modern Holstein population is about 1.1%. It has been established that there are no carriers of haplotype HH7 among the Holstein breed cows and bulls used in the artificial insemination system in the Krasnodar Territory. The article presents the sequences of primers and the method of genotyping. The problem of spreading the haplotype HH7 carrier for dairy cattle breeding in the Krasnodar Territory is currently not relevant. However, it is desirable to include testing for the presence of haplotype HH7 together with testing for the presence of other haplotypes of Holstein cattle (HH1, HH2, HH3, HH4, HH5, HSD) in the list of mandatory genetic studies of breeding bulls in order to prevent the further spread of mutation in the CENPU gene.
Conhecimento de familiares e cuidadores sobre cuidados paliativos: revisão integrativa de literatura
Authors: Ferreira Roberto Emanuel Bueno , Signolfi Rafaela Rossi , Pena Juliana Corrêa , Bobroff Maria Cristina Cescatto 
Published: November 2022

Cuidados Paliativos são abordagens promovida por uma equipe interprofissional, que visam tratar e prevenir o sofrimento dos pacientes com doenças ameaçadoras da vida, promovendo conforto para eles e seus familiares. Portanto, devido a fatores culturais, políticos dentre outros, o entendimento de familiares sobre o tema é tênue. Dessarte, objetivou-se identificar o conhecimento de familiares e cuidadores sobre CP em base de dados científicas da literatura nacional e internacional. Estudo de Revisão Integrativa de Literatura com busca de artigos nas bases de dados online BVS, PubMed e SciELO, abrangendo artigos publicados entre janeiro de 2015 a dezembro de 2020. Adotados como critérios de inclusão: artigos gratuitos, em um dos idiomas: Português, Inglês e Espanhol com os descritores: Cuidados Paliativos, Percepção, Família, Cuidadores e Conhecimento e uso do operador Booleano (AND). Utilizou-se a estratégia PICO (patient, intervention, comparison, outcomes), além do guideline PRISMA (2020). Foram encontrados 1358 artigos nas bases de dados supracitadas sendo 83 selecionados para análise e cinco para a revisão. Dos artigos selecionados três provêm de pesquisas realizadas no Brasil, um no México e um na Alemanha. Analisando-se as semelhanças e diferenças entre os resultados, surgiram três categoriais temáticas: 1) Falta de políticas públicas; 2) Má divulgação da modalidade de cuidado; 3) Desconhecimento dos profissionais da saúde e da comunidade. O conhecimento de CP entre familiares e cuidadores ainda são insuficientes e refletem a fragilidade na educação de profissionais de saúde e a conturbada comunicação equipe-família-cuidadores.
Cervejaria industrial versus artesanal: um estudo comparativo sobre o gerenciamento da água e resíduos de acordo com a P+L
Authors: Barreira Isabela Barbosa de Freitas , Monteiro Luciane Pimentel Costa , Simões Rita de Cassia Colman 
Published: November 2022

A água é a principal matéria prima da cerveja, sendo indispensável durante todo o seu processo produtivo, o que faz com que grandes volumes da mesma sejam gastos. Por isso, foram visitadas duas cervejarias: uma industrial e outra artesanal, depois disso foram verificadas todas as etapas do processo produtivo, seus respectivos impactos, e se existia alguma redução do mesmo na fonte, reaproveitamento interno ou algum reaproveitamento externo, de acordo do a P+L. Os resultados obtidos mostraram que embora o impacto ambiental seja maior na cervejaria industrial e seu gasto de água seja de 240 a 360 vezes maior que a empresa menor, a mesma tem muitos mecanismos de redução de impacto. Cerca de 55% do consumo de água foi reduzido nos últimos 18 anos e 99% dos resíduos sólidos também. O consumo de água por litro da bebida era de 5,36L e caiu para 2,4L e reutiliza 500m3 de efluente tratado para lavagem da área externa da empresa. No envase, a envasadora é alinhada por um temporizador, que reduz a perda de água na troca de garrafas. As embalagens usadas são 100% retornáveis e o gasto nessa etapa já foi reduzido em 20%. Todos os processos de fabricação possuem hidrômetros próprios, monitorando quantitativamente o gasto de água. Já na empresa artesanal, o consumo de água por litro de cerveja era de aproximadamente 10L em 2011, e hoje é de aproximadamente 5,5L, uma redução de 45%. Apesar de fazerem o reaproveitamento do bagaço e da levedura, não existe acompanhamento desses indicadores. Não existe reaproveitamento do efluente gerado, e por isso, é a fabricação menos adepta ao método de produção mais limpa.
Estudos da atividade antioxidante de novas tinturas mãe homeopáticas de plantas medicinais da região de Governador Valadares-MG
Authors: Andrade Larissa Martins Duarte , Noman Rafael , Pereira Michelle Bueno de Moura , De Castro Sandra Bertelli Ribeiro , Alves Caio Cesar de Souza , Bertoldi Michele Correa , Antunes João Eustáquio 
Published: November 2022

As tinturas mães (TM’s) são extratos etanólicos obtidos a partir de plantas, sendo um tipo de formulação muito comum a ser utilizado na produção de medicamentos homeopáticos. Seu efeito terapêutico está parcialmente atribuído à presença de fitoquímicos e associados, muitas vezes, ao saber popular. Neste trabalho foram estudadas treze tinturas mães obtidas a partir de diferentes plantas coletadas na região de Governador Valadares-MG. As TM’s foram preparadas pelo processo de maceração de material vegetal fresco das plantas em solução hidroalcoólica. A viabilidade celular e a produção de óxido nítrico das TM’s foram obtidas pelo método MTT nas linhagens de macrófagos murinos RAW 264.7. Foram testados também teor de compostos fenólicos totais (TPC) e a atividade antioxidante (AA) usando radicais livres. De modo geral, as TM’s não apresentaram citotoxicidade à cultura de células RAW 264.7. Não houve redução significativa da viabilidade celular da linhagem de macrófagos testadas pelas TM’s, o que pode demonstrar baixa toxicidade celular. Todos os extratos das TM’s inibiram a produção de NO em determinadas concentrações testadas, porém os extratos das TMs 6, 7, 12, e 13 foram os que tiveram os melhores resultados para este teste. As TM’s que tiveram maior teor de compostos fenólicos foram: TM’s 5, 6 e 12. Já as TM’s, que apresentaram maior atividade antioxidante foram:7, 3; 6 12. Podemos destacar neste estudo a importância da presença de compostos fenólicos com potencial atividade antioxidante observado nas TM’s. Assim, pode-se concluir que algumas TM’s estudadas, além da atividade antioxidante também apresentaram capacidade de inibição da produção de NO, sendo, portanto, amostras promissoras para estudos posteriores.
Mobility degradation under a high effective normal field in an inversion layer of 4H-SiC (0001) metal–oxide–semiconductor structures annealed in POCl3
Authors: Ito Koji , Kimoto Tsunenobu 
Published: November 2022

Abstract
Mobility degradation under a high effective normal field (1 MV cm−1 < E
eff < 2 MV cm−1) in an inversion layer of 4H-silicon carbide (SiC) (0001) metal–oxide–semiconductor field-effect transistors (MOSFETs) annealed in POCl3 is investigated by applying a negative body bias (0 V ≥ V
BS ≥ −40 V). The effective channel mobility (μ
eff) is proportional to E
eff
−2.3–−2.2 in the range 1 MV cm−1 ≤ E
eff. On the basis of the obtained results, the authors propose that the mobility degradation in the high-E
eff region is caused by strong surface roughness scattering in SiC MOSFETs with a very low interface state density.
ANALISIS KELAYAKAN USAHA PENGGILINGAN PADI DITINJAU DARI ASPEK FINANSIAL DI KECAMATAN LUBUK PINANG KABUPATEN MUKOMUKO
Authors: Feriady Anton , Mutmainnah Elni , Satria Arif 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui usaha penggilingan padi ditinjau dari aspek kelayakan finansial di Kecamatan Lubuk Pinang Kabupaten Mukomuko. Metode yang digunakan dalam penelitian ini adalah metode sensus, metode sensus adalah teknik pengambilan sampel di mana seluruh anggota populasi dijadikan sampel semua dan dijadikan responden pemberi informasi.Responden dalam penelitian ini adalah enam resonden. Waktu pelaksaan penelitian ini yaitu pada bulan september dan oktober 2020 di Kecamatan Lubuk Pinang Kabupaten Mukomuko. Data yang digunakan ada dua data yaitu, data primer dan data sekunder. penentuan lokasi dilakukan secara sengaja. Hasil penelitian menunjukkan bahwa usaha penggilingan padi keli di Kecamatan Lubuk Pinang Kabupaten Mukomuko menguntungkan dengan keuntungan yaitu sebesar Rp219.295.833,00 Dalam keadaan nomal NPV positif, Rp137.217.941,00 Net B/C = 2.1 dan Internal Rate Of Return = 28,77% Dalam analisis sensitivitas biaya naik sebesar 3% NPV positif, sebesar Rp94.344.241,00 Net B/C = 1,8 artinya, > 1 dan Internal Rate Of Return = 25,78%. Dalam keadaan penerimaan turun sebesar 2% NPV positif, Rp134.478.786,00
Net B/C = 2,1 dan Internal Rate Of Return = 28,54%.
Kata kunci: kelayakan usaha, penggilingan padi
Pengaruh Macam dan Konsentrasi ZPT Sintetik Terhadap Fase Vegetatif Tanaman Kedelai (Glycine Max L.)
Authors: Putri Ineke , Miftakhurrohmat A. 
Published: November 2022

Abstrak Penelitian ini bertujuan untuk mengetahui interaksi ZPT sintetik dan konsentrasi terhadap fase vegetatif tanaman kedelai, dilaksanakan di Desa Jogosatru Kecamatan Sukodono Kabupaten Sidoarjo dan pengamatan lanjutan dilakukan di Laboratorium Agroteknologi Fakultas Sains dan Teknologi Universitas Muhammadiyah Sidoarjo mulai pada bulan November sampai Desember 2021. Penelitian ini menggunakan Rancangan Acak Kelompok pola faktorial dilanjutkan dengan uji BNJ. Faktor pertama adalah ZPT sintetik auksin (Z1), sitokinin (Z2), giberilin (Z3) dan faktor kedua adalah konsentrasi ZPT 5 ppm (K1), 7 ppm (K2), 9 ppm (K3) yang diulang sebanyak 3 kali. Hasil penelitian menunjukkan bahwa perlakuan ZPT sintetikÂ giberilin dengan konsentrasi 7 ppm (Z3K2) dapat meningkatkan kecepatan perkecambahan dan terjadi interaksi sangat nyata pada variabel pengamatan panjang akar dan luas daun kemudian interaksi yang nyata antara perilaku ZPT sintetik dan konsentrasi pada variabel pengamatan jumlah daun pada usia 14, 21 28 HST, berat basah ,berat kering kecambah dan jumlah klorofil. Pada perlakuan macam ZPT sintetik menunjukkan pengaruh yang nyata pada variabel pengamatan tinggi tanaman pada usia 28 HST, perlakuan ZPT auksin (Z1) menunjukkan nilai rata-rata tertinggi pada parameter tinggi tanaman. Sedangkan perlakuan konsentrasi ZPT sintetik menunjukkan pengaruh yang nyata pada variabel pengamatan tinggi tanaman pada usia 7 dan 21 HST dan jumlah daun pada usia 7 HST.Â Kata kunci : kedelai, ZPT sintetik,konsentrasi.