bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive Factors of Medium-Large Coronary Artery Aneurysm in Children with Acute Kawasaki Disease: A Retrospective Cohort Study
Authors: Liu Jie , Su Danyan , Ye Bingbing , Qin Suyuan , Chen Cheng , Pang YuSheng 
Published: January 2022

Abstract
Background: The severity of the cardiac complications resulting from Kawasaki disease (KD) appears to be directly correlated to the magnitude of the coronary artery aneurysm (CAA). However, there remains some unclear about the risk factors for medium-large CAA identified after acute KD.Methods: We analyzed 90 patients diagnosed with CAA in KD hospitalized from January 2013 through August 2021. Patients were stratified based on the coronary artery z-score adjusted for body surface area as the medium-large CAA group and small-sized CAA group. The association of baseline characteristics was investigated within the groups. Multivariable logistic regression analyses were performed to evaluate potential risk factors associated with medium-large CAA development.Results: In total, 353 pediatric cases with KD were investigated during the study period, of whom 90 (25.5%) presented with CAA, including medium-large CAA in 20 patients (5.7%) after acute KD. The medium-large CAA group showed significantly higher Harada risk scores, the incidence of thrombosis, serum globulin concentration values, proportions of C-reactive protein > 40 mg/L, proportions of albumin < 35 g/L, and lower values of albumin-to-globulin ratio (A/G ratio) than those in the small-sized CAA group (P < 0.05). Medium-large CAA was significantly associated with the A/G ratio (odds ratio, 3.503; 95% confidence interval [CI]: 1.068–11.492). The area under the receiver operating characteristic curve was 0.684 (95% CI: 0.558–0.810), and the cutoff point of 1.35 showed a sensitivity and specificity for predicting medium-large CAA of 80% and 59%, respectively.Conclusions: A lower A/G ratio independently predicts medium-large CAA in patients with KD. Medium-large CAA is associated with greater odds of developing thrombosis. Thus, close monitoring with routine echocardiography is recommended.
Integrin Alpha L as an Immune-Related Biomarker Correlated with the Prognosis and Effect of Immunotherapy in Gliomas
Authors: Ma Jinyang , Wang Lei , Zhou Youdong , Fu Changtao , Huang Song , Lang Bojuan 
Published: January 2022

Abstract
Backgroud:

Discovering effective immune-related biomarkers is vital to ensure efficient immunotherapy for glioma patients. Integrin Alpha L(ITGAL), essential to inflammatory and immune responses, have not been studied in gliomas, systematically.
Methods

RNA‑seq data and corresponding clinical information of glioma patients were collected from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA), and mRNA data of normal brain tissues were obtained in Genotype-Tissue Expression (GTEx) project. Wilcoxon test was performed to analyze the correlation of ITGAL expression and glioma subtypes. Univariate and multivariate cox proportional hazards regression, receiver operating characteristic (ROC) curves and Kaplan-Meier plots were used to evaluate the prognostic value of ITGAL in glioma. Functional enrichment analyses and immune infiltration analysis were performed to investigate the potential function in mediating the immune response in the tumor microenvironment. Finally, we evaluated the ability of ITGAL for predicting the efficacy of ICB treatment for patients.
Results

We found the up-regulation of ITGAL may predict a poor prognosis for glioma patients, the expression level increased with the increasing of WHO grade and 1p19q co-deletion status and IDH mutation status. The total methylation level and copy number variation of ITGAL were moderately correlated with its mRNA expression in LGG samples (P < 0.05). Furthermore, ITGAL was correlated with the immunosuppressive tumor microenvironment for the strong correlation with M2 macrophages and Tregs. Finally, GSEA showed the upregulation of ITGAL was mainly involved in the signal recognition and regulation between immune cells, and Toll-like receptor signaling pathway.
Conclusion

ITGAL is a novel tumor-related and immune-associated biomarker, which could predict the prognosis and effect of ICB therapy for glioma patients.
Moving From Evidence To Decisions in Guidelines: An Analysis of Guidance Documents
Authors: Meneses-Echavez Jose F , Bidonde Julia , Yepes-Nuñez Juan Jose , Peričić Tina Poklepović , Puljak Livia , Bala Malgorzata M , Storman Dawid , Swierz Mateusz , Zając Joanna , Montesinos-Guevara Camila , Zhang Yuan , Guapo Nathaly Chavez , Schünemann Holger , Flottorp Signe , Alonso-Coello Pablo 
Published: January 2022

Abstract
Background
The process of moving from evidence to decisions (EtD) represents a cornerstone within guideline development methods. Little is known about the processes used by organizations in charge of guideline development and what criteria they consider when formulating recommendations.
Objective
To identify and describe the processes suggested for the formulation of healthcare recommendations in health care guidelines available in guidance documents.
Methods
We searched in spring 2020 the Guidelines International Network (G-I-N) website, MEDLINE, and The Cochrane Methodology Register to retrieve guidance documents published in the last decade by organizations dedicated to guideline development. Pairs of researchers independently selected and extracted data about the characteristics of the guidance document, including explicit or implicit recommendation-related criteria and processes considered, as well as the use of frameworks. We conducted both descriptive and bivariate analyses.
Results
We included 68 guidance documents, published mostly by scientific societies (58%). Most of the organizations reported a system for grading the strength of recommendations (88%), half of them being the GRADE approach. Two out of three guidance documents (66%) proposed the use of a framework to guide the EtD process. We identified 14 recommendation-related criteria. The GRADE Evidence to Decision (GRADE-EtD) framework was the most often reported framework (19 organizations, 42%), whereas 20 organizations (44%) proposed their own multi-criteria frameworks. Using any EtD framework was related with a more comprehensive set of recommendation-related criteria compared to no framework, especially for criteria like values, equity, and acceptability. A similar association was observed between the GRADE-EtD framework and either no framework or another EtD frameworks.
Conclusion
The use of systematic and structured processes for moving from evidence to decisions is still limited among international organizations. The use of EtD frameworks facilitates the inclusion of relevant recommendation criteria. Among the structured frameworks, the GRADE-EtD framework offers the most comprehensive perspective for evidence-informed decision-making processes. More complete and detailed reporting in the guidance documents is warranted.
An Exploration of Registered Dietitian Accreditation System Development in China
Authors: Wang Xiaoli , Zhang Yajie , Liu Ya , Shen Xiuhua , Xiao Rong , Zhu Huilian , Zeng Guo , Yang Yuexin , Cai Wei , Ma Aiguo 
Published: January 2022

Abstract
Background:

To review the highlights of the registered dietitian accreditation system in China, including history, organization, regulatory policies, certification requirements, development, and performance on the certification examination, registration, and continuing education, the process for the accreditation system development was focused. The data from the certification examinations and registrations were collected and analyzed. The eligibility requirements, as well as practice pathways, were discussed. Lessons learned from the development of the registered dietitian accreditation system, opportunities, challenges, and future directions for the field were discussed. There remain needs for well-established degree programs and a professional organization’s maintenance with endeavouring in job opportunities, as well as legislative concerns.
Presumed Ocular Tuberculosis: A Retrospective Case Series
Authors: Grodsky Jacob , Lee John , Piri Niloofar 
Published: January 2022

Abstract
Purpose
Despite the common misconception that tuberculosis is an uncommon disease in developed countries such as the United States, cases have become increasingly more prevalent. We aim to further the ophthalmologic understanding of this disease through the presentation of clinical findings in nine cases of presumed ocular tuberculosis seen at our institution.
Methods
Retrospective case review of all patients diagnosed with tuberculosis with encounters at Saint Louis University Hospital and SLUCare between 1/1/2011 and 3/1/2021.
Results
Nine patients, 6 females and 3 males ages 18-60 years, were included in this study. All cases (100%) presented with a variety of ocular involvement including anterior uveitis, panuveitis, optic nerve edema, sequential papillitis, granulomatous uveitis, peripheral vasculitis, and possible choroidal granuloma. Known history of tuberculosis exposure was only obtained in 22% of patients.
Conclusion
The low proportion of patients with known history of tuberculosis exposure and manifestations of ocular tuberculosis highlights the general lack of presumption of diagnosis amongst our population. Patients without known exposure and without extraocular manifestations are most at risk for being misdiagnosed and left untreated for tuberculosis. It is important to address this issue with studies leading to more precise diagnostic guidelines and protocols so that patients will be treated in a timely manner to prevent irreversible visual damage secondary to intraocular inflammation as well as potential systemic manifestations of tuberculosis.
Prescribed Performance Tracking Control for High-Order Uncertain Nonlinear Systems
Authors: Ding Jiling , Zhang Weihai 
Published: January 2022

Abstract
This paper considers the prescribed performance tracking control for high-order uncertain nonlinear systems. For any initial system condition, a state feedback control is designed, which guarantees the prescribed tracking performance and the boundedness of closed-loop signals. The proposed controller can be implemented without using any approximation techniques for estimating unknown nonlinearities. In this respect, a significant advantage of this article is that the explosion of complexity is avoided, which is raised by backstepping-like approaches that are typically employed to the control of uncertain nonlinear systems, and a low-complexity controller is achieved. Moreover, contrary to the existing results in existing literature, the restrictions on powers of high-order nonlinear systems are relaxed to make the considered problem having stronger theoretical and practical values. The effectiveness of the proposed scheme is verified by some simulation results.
Analyze the Outbreak of COVID-19 in Wuhan City Based on Large-Scale Events and Extreme Weather
Authors: Xie De-ming , Wang Tianyu , Liu Hai , Jiang Pan 
Published: January 2022

Abstract
This article analyzes the impact of large-scale mass activities and extreme weather on the outbreak of COVID-19 in Wuhan, confirming that the South China Seafood Market is indeed the origin of the Wuhan epidemic, and found that the probability of respiratory transmission is low in open space, while food transmission is possible. At the same time, it was found that the outbreaks of SARS in Beijing in 2003 and COVID-19 in Wuhan in 2019 were both related to extreme weather. By investigating genomics and epidemiological data, it was determined that the first COVID-19 case in Wuhan was in November, and the beginning of the epidemic was in late November. Comparing the climate of November, December and January in Wuhan from 2011 to 2020, it is found that there are a lot of extreme weather events in Wuhan from the end of 2019 to the beginning of 2020, including strong winds, heavy rains, large cooling after continuous high temperature, and continuous low temperature and rainy after large cooling, the temperature suddenly rises and then drops rapidly, the wind continues to weaken for many days and then suddenly increases, and long rainy days, etc.
Identification of Lens Cultivars in Market by Molecular Tools: DNA Barcoding and SSRs
Authors: TATLISES Metin Burak , Hasancebi Semra 
Published: January 2022

Abstract
Substitution of plant cultivars of high commercial value with a cheaper, lower-quality one is a common fraud committed against consumers and producers. Since it is one of the most widely grown legumes, lentil (Lens culinaris Medik.) are a suitable for such frauds. This study aimed to identify lentil cultivars which are registered and authorized in the market in Turkey by using current molecular methods. For this purpose, 26 lentil cultivars were analyzed for 15 SSR markers and 2 DNA barcode loci (trnH-psbA and matK). A high allele diversity was observed by 12 scorable SSR markers, and the average number of alleles was determined to be 16. One of the important findings was the presence of “cultivar-specific alleles” that can be used to identify each cultivar in the lentil market in Turkey. At least one “cultivar-specific allele” was obtained for each cultivar. The lentil cultivars were analyzed in terms of 2 DNA barcode regions as trnH-psbA and matK. Sequences that could identify 14 of the 26 cultivars were obtained. While the rate of the intra-species variation for the trnH-psbA region was observed to be low, a higher rate was found for matK. Nevertheless, it was observed that intra-species discrimination can be made more effective when both loci are used together. We expect that the results of this study, especially the cultivar-specific SSR alleles and DNA barcoding sequence data may be used routinely to identify on production and packaged products that are commercially available in markets.
Evaluation of Brain Structure Based on Voxel and Surface Morphology in Adults with MRI Negative Temporal Lobe Epilepsy
Authors: Yang Fan , Kukun Hanjiaerbieke , Jia Wenxiao , Ding Shuang , Zhao Wei , Wang Yunling 
Published: January 2022

Abstract
Background
MRI-negative TLE (TLE-N) is a manifestation lacks visible MRI findings yet with detectable electrophysiological changes. In this study, differences of gray matter in drug-controlled MRI negative temporal lobe epilepsy (cTLE-N) and drug-resistant MRI negative temporal lobe epilepsy (rTLE-N) patients were calculated and analyzed by voxel-based morphology (VBM) and surface-based morphology (SBM), to discover the brain structural changes of TLE-N patients.
Materials and methods
Consecutive resident patients with 30 cTLE-N and 21 rTLE-N were recruited into respective groups, and 30 healthy controls’ structural MRI (sMRI) data collected as a control group. Open-source software based on VBM and SBM was deployed as gray matter volume (GMV) and cortical thickness (CT) analytic tools.
Results
VBM analysis showed that GMV of bilateral thalamus and right lingual gyrus of cTLE-N group, and left hippocampus, left fusiform gyrus and left thalamus of rTLE-N group were smaller compared to HC group(FDR corrected, P<0.05), while right cerebellum, inferior temporal gyrus, hippocampus, parahippocampal gyrus, amygdala, fusiform gyrus, orbital middle frontal gyrus, and left posterior central gyrus in cTLE-N group, and bilateral cerebellum and middle temporal gyrus, right fusiform gyrus, amygdala, hippocampus, and left middle occipital gyrus of rTLE-N group were greater than HC group(FDR corrected, P<0.05). SBM analysis showed that CT of the left medial orbitofrontal cortex and lateral occipital cortex in cTLE-N group, and thickness of the left medial orbitofrontal, temporal pole, middle temporal gyrus and right anterior superior cingulate cortex in rTLE-N group were thinner, compared to HC group. Correlation analysis showed that GMV and CT of different structures were correlated with age of onset, disease duration, and MoCA score.
Conclusion
This study utilized two different sMRI analytic tools and discovered several brain morphological changes in TLE-N. These morphological changes were also correlated with clinical variables. Further study may indicate the potential of these findings on the recognition of the TLE-N epilepsy network.
Gold Nanoparticle Effects on the Hounsfield Unit of Computed Tomography in Hepatocellular Carcinoma: Systematic Review
Authors: Gourani Pouya , Sedeh Amirhossein Barati , Zareyi Hajar , Shirvaliloo Milad , Sheervalilou Roghayeh , Ghaznavi Habib 
Published: January 2022

Abstract
Background: The present study has attempted to gather all the original and relevant data on the application of gold nanoparticles aimed at the improvement of computed tomography image quality and Hounsfield unit in hepatocellular carcinoma. We performed a systematic review on the studies indexed in PubMed from January 2000 to January 2020. Afterwards, the study design and quality were evaluated. Results: An increase in the nanoparticles concentration and incubation time was associated with improved image quality and the Hounsfield Unit of computed tomography. Conclusion: This study highlights the considerable diagnostic role of gold nanoparticle as novel contrast agents in the early detection of hepatocellular carcinoma.
Decoding Human Visual Colour EEG Information Using Machine Learning and Visual Evoked Potentials
Authors: Wu Yijia , Zeng Xinhua , Feng Kaiqiang , Wei Donglai , Song Liang 
Published: January 2022

Abstract
With the rapid development of brain-computer interfaces (BCIs), human visual decoding, one of the important research directions of BCIs, has attracted a substantial amount of attention. However, most visual decoding studies have focused on graphic and image decoding. In this paper, we first demonstrate the possibility of building a new kind of task-irrelevant, simple and fast-stimulus BCI-based experimental paradigm that relies on visual evoked potentials (VEPs) during colour observation. Additionally, the features of visual colour information were found through reliable real-time decoding. We selected 9 subjects who did not have colour blindness to participate in our tests. These subjects were asked to observe red, green, and blue screens in turn with an interstimulus interval of 1 second. The machine learning results showed that the visual colour classification accuracy had a maximum of 93.73%. The latency evoked by visual colour stimuli was within the P300 range, i.e., 176.8 milliseconds for the red screen, 206.5 milliseconds for the green screen, and 225.3 milliseconds for the blue screen. The experimental results hereby show that the VEPs can be used for reliable colour real-time decoding.
Fixation of Superomedially Displaced Acetabular Fractures Using an Anatomical Suprapectineal Quadrilateral Surface Plate Through Modified Stoppa Approach
Authors: Kwak Dae-Kyung , Lee Seunghun , Lee Yongmin , Hwang Ji-Hyo , Yoo Je-Hyun 
Published: January 2022

Abstract
Treatment of superomedially displaced acetabular fractures including a quadrilateral surface (QLS) is challenging. We present a surgical technique using an anatomical suprapectineal QLS plate through the modified Stoppa approach and report the availability of this plate to treat this fracture type along with the surgical outcomes. Thirteen consecutive patients (11 men and 2 women) who underwent surgical treatment using an anatomical suprapectineal QLS plate through a modified Stoppa approach for superomedially displaced acetabular fractures between June 2018 and June 2020, were enrolled retrospectively. These fractures included 10 both-column fractures and 3 anterior-column and posterior hemitransverse fractures, which were confirmed on preoperative 3-dimensional computed tomography. Surgical outcomes were clinically assessed using the Postel Merle d’Aubigné (PMA) score and visual analog scale (VAS) score at the final follow-up, and radiological evaluations were performed immediately after the operation and at the final follow-up. The follow-up period was longer than 1 year in all patients with a mean 22.9 months. The mean operation time was 103 min. Anatomical reduction was achieved in 11 (84.6%) patients, while imperfect reduction was achieved in the remaining two (15.3%) patients. At the final follow-up, radiographic grades were excellent, fair, and poor in 11 (84.6%), one (7.6%), and one patient, respectively. The mean PMA score was 16.3 (range, 13-18) and the mean VAS score was 1.0 (range, 0-3). No secondary reduction loss or implant loosening was observed. However, two patients underwent conversion to total hip arthroplasty due to post-traumatic arthritis and subsequent joint pain. No other complications were observed. Simultaneous reduction and fixation using an anatomical suprapectineal QLS plate through the modified Stoppa approach can provide satisfactory outcomes in superomedially displaced acetabular fractures, resulting in shorter operation times and fewer complications.
Strategies To Support Older Adults’ Mental Health During the Transition Into Residential Aged Care: A Qualitative Study of Multiple Stakeholder Perspectives
Authors: Polacsek Meg , Woolford Marta 
Published: January 2022

Abstract
BackgroundThe move from home into residential care is one of the most stressful life experiences for older adults. ‘Relocation stress’ is a significant risk factor for anxiety and/or depression in aged care residents. Whether long-term or recently diagnosed, these mood disorders are associated with a decline in overall well-being, daily functioning and independence. The mental health needs of older adults are often poorly recognised and supported, including during the transition into residential care. Despite growing interest in how to facilitate this major life transition, few studies have taken the perspective of multiple stakeholders. The aim of this study was to explore resident, relative and staff experiences of the transition into residential aged care, and to identify strategies to support the mental health of older adults at this time. MethodsSemi-structured interviews were conducted with 35 aged care residents, relatives and staff, between January and April 2021. Participants were selected using purposive and convenience sampling. Interviews were audio recorded and transcribed verbatim. Data were analysed inductively and grouped into themes. ResultsResults were distilled into three main categories related to the overall transition experience, residents’ mental health needs and strategies to support residents’ mental health. A novel contribution of this study relates to the need to address a broad misunderstanding of the role of pastoral care and subsequent under-utilisation of a potentially valuable resource. ConclusionsBy describing transition experiences and the resources to support residents’ mental health, findings of this study provide practical, ‘real world’ suggestions for reducing relocation stress. New resources developed from the findings include guides, checklists and short question-and-answer films, in which current residents and staff describe strategies to support mental health and overall quality of life. Similar resources could be used to support transitions in other care settings.