bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNAJC10 correlates with tumor immune characteristics and predicts the prognosis of glioma patients
Authors: Liu Feng , Tu Zewei , Liu Junzhe , Long Xiaoyan , Xiao Bing , Fang Hua , Huang Kai , Zhu Xingen 
Published: January 2022

Abstract
Background: The role of DnaJ heat shock protein family (Hsp40) member C10 (DNAJC10) in cancers has been reported but its function in glioma is not clear. We reveal the prognostic role and underlying functions of DNAJC10 in glioma in the present study.
Methods: Reverse Transcription and Quantitative Polymerase Chain Reaction (RT-qPCR) was used to quantify the relative DNAJC10 messenger RNA (mRNA) expression of clinical samples. Protein expressions of clinical samples were tested by Western blot. The overall survival (OS) of glioma patients with different DNAJC10 expression was compared by Kaplan–Meier method (two-sided log-rank test). Single-sample gene set enrichment analysis (ssGSEA) was used to estimate the immune cell infiltrations and immune-related function levels. The independent prognostic role of DNAJC10 was determined by univariate and multivariate Cox regression analyses. The DNAJC10-based nomogram model was established using multivariate Cox regression by R package ‘rms’.
Results: Higher DNAJC10 is observed in gliomas and it is up-regulated in higher grade, isocitrate dehydrogenase (IDH)-wild, 1p/19q non-codeletion, O(6)-methylguanine-DNA methyltransferase (MGMT) unmethylated gliomas. Gliomas with higher DNAJC10 expression present poorer prognosis compared with low-DNAJC10 gliomas. The predictive accuracy of 1/3/5-OS of DNAJC10 is found to be stable and robust using time-dependent ROC model. Enrichment analysis recognized that T-cell activation and T-cell receptor signaling were enriched in higher DNAJC10 gliomas. Immune/stromal cell infiltrations, tumor mutation burden (TMB), copy number alteration (CNA) burden and immune checkpoint genes (ICPGs) were also positively correlated with DNAJC10 expression in gliomas. DNAJ10-based nomogram model was established and showed strong prognosis-predictive ability.
Conclusion: Higher DNAJC10 expression correlates with poor prognosis of glioma and it was a potential prognostic biomarker for glioma.
Spheroidal force-free neutron star magnetospheres
Authors: Pétri J. 
Published: January 2022

Context. Fast rotating and self-gravitating astrophysical objects suffer strong deformations from centrifugal forces. If, moreover, they are magnetised, they generate an electromagnetic wave that is perturbed accordingly. When stellar objects are also surrounded by an ideal plasma, a magnetosphere is formed. For neutron stars, a relativistic magnetised wind is launched, efficiently extracting rotational kinetic energy flowing into particle creation and radiation.
Aims. We study the electromagnetic configuration of a force-free magnetosphere encompassing an ideal spheroidal rotating conductor as an inner boundary. We put special emphasis on millisecond period neutron star magnetospheres, that is those showing a significant oblate shape. For completeness, we also investigate the effect of prolate stars.
Methods. Force-free solutions were computed by numerical integration of the time-dependent Maxwell equations in spheroidal coordinates using pseudo-spectral techniques. Relevant quantities such as the magnetic field structure, the spin-down luminosity, the polar cap rims, and the current density are shown and compared to the force-free spherical star results.
Results. We find that the force-free magnetic field produced by spheroidal stars remains very similar to their spherical counterpart. However, the spin-down luminosity slightly decreases with increasing oblateness or prolateness. Moreover, the polar cap area increases and, for the most part, always encompasses the equivalent spherical star polar cap rims. The polar cap current density is also drastically affected.
Conclusions. Neutron stars are significantly distorted by either rotational effects such as millisecond pulsars or by magnetic pressure such as magnetars and high magnetic field pulsars. An observational interpretation of and fitting a thermal X-ray pulsation will greatly benefit from an accurate and quantitative analysis similar to the one presented in this paper. However, even for the fastest possible rotation, the effect would certainly be unobservable, in the sense that we cannot predict what feature of the light curve would supposedly reveal the neutron star deformation due to fast rotation.
Endovascular Management of Internal Carotid Artery Pseudoaneurysm Secondary to Pediatric Deep Neck Space Infection: A Case Report and Review of Literature
Authors: Rajagopal Rengarajan , Sharma Smily , Bagarhatta Meenu , Tiwari Sarbesh , Bagarhatta Rajeev 
Published: January 2022

AbstractPseudoaneurysms of extracranial internal carotid artery (ICA) are rare in children. Main causes include trauma, iatrogenic causes, and neck space infection. Prompt diagnosis and management is vital, in view of life-threatening complications like fatal airway hemorrhage and stroke. Endovascular management has currently become the preferred treatment strategy due to its minimally invasive nature and lower complication rates. We report a rare case of mycotic pseudoaneurysm of extracranial ICA in a 4-year-old child as a complication of neck space infection, which was successfully managed with endovascular parent artery occlusion.
Risk and Management of Intracerebral Hemorrhage in Patients with Bleeding Disorders
Authors: Dorgalaleh Akbar , Farshi Yadolah , Haeri Kamand , Ghanbari Omid Baradarian , Ahmadi Abbas 
Published: January 2022

AbstractIntracerebral hemorrhage (ICH) is the most dreaded complication, and the main cause of death, in patients with congenital bleeding disorders. ICH can occur in all congenital bleeding disorders, ranging from mild, like some platelet function disorders, to severe disorders such as hemophilia A, which can cause catastrophic hemorrhage. While extremely rare in mild bleeding disorders, ICH is common in severe coagulation factor (F) XIII deficiency. ICH can be spontaneous or trauma-related. Spontaneous ICH occurs more often in adults, while trauma-related ICH is more prevalent in children. Risk factors that can affect the occurrence of ICH include the type of bleeding disorder and its severity, genotype and genetic polymorphisms, type of delivery, and sports and other activities. Patients with hemophilia A; afibrinogenemia; FXIII, FX, and FVII deficiencies; and type 3 von Willebrand disease are more susceptible than those with mild platelet function disorders, FV, FXI, combined FV–FVIII deficiencies, and type 1 von Willebrand disease. Generally, the more severe the disorder, the more likely the occurrence of ICH. Contact sports and activities can provoke ICH, while safe and noncontact sports present more benefit than danger. An important risk factor is stressful delivery, whether it is prolonged or by vacuum extraction. These should be avoided in patients with congenital bleeding disorders. Familiarity with all risk factors of ICH can help prevent occurrence of this diathesis and reduce related morbidity and mortality.
An ACS-NSQIP Analysis of Unicompartmental Knee Arthroplasty Trends from 2013 to 2018
Authors: Cochrane Niall , Belay Elshaday , Wu Mark , O'Donnell Jeffrey , Kim Billy , Seyler Thorsten 
Published: January 2022

AbstractUnicompartmental knee arthroplasty (UKA) volume has increased with advances in implant design, perioperative protocols, and patient selection. This study analyzed national trends of UKA from 2013 to 2018 and the relationship between patient demographics and postoperative outcomes. Data on UKA (CPT 27446) from 2013 to 2018 was collected from the National Surgical Quality Improvement Program (NSQIP). Variables collected included patient demographics, American Society of Anesthesiology classification, functional status, NSQIP morbidity probability, operative time, length of stay, 30-day reoperation, and readmission rates. There was an increase in outpatient UKAs performed (920 in 2013; 11,080 in 2018) (p < 0.0001). Analysis of variance from 2013 to 2018 revealed significant decrease in patient body mass index (BMI) (32.5 in 2013; 31.5 in 2018) (p < 0.01) and NSQIP morbidity probability (0.014 in 2013; 0.011 in 2018) (p < 0.0001). Operative time increased (79.1 minutes in 2013; 84.4 minutes in 2018) (p < 0.01), but length of stay decreased (0.9 days in 2013; 0.5 days in 2018) (p < 0.0001). The number of all-cause and related readmissions decreased significantly (p < 0.045; p < 0.01). Age, male gender, BMI >40 and chronic obstructive pulmonary disease (COPD) were significant predictors for 30-day readmission. BMI >40 was a significant predictor for discharge destination. UKA has seen a rise in incidence from 2013 to 2018 with an increasing number of outpatient UKAs. Operative times and 30-day readmissions have both decreased in this time. BMI > 40 is predictive for discharge destination after UKA, while age, male gender, BMI >40, and COPD are independent risk factors for 30-day readmission.
Anteromedial Tibial Attachment in Single-Bundle Anterior Cruciate Ligament Reconstruction Can Represent Normal Kinematics in Computer Simulation
Authors: Nakamura Shinichiro , Tanaka Yoshihisa , Kuriyama Shinichi , Nishitani Kohei , Watanabe Mutsumi , Yamauchi Kenshiro , Song Young D. , Matsuda Shuichi 
Published: January 2022

AbstractTunnel position during anterior cruciate ligament (ACL) reconstruction is considered as an important factor to restore normal knee kinematics and to gain better clinical outcomes. It is still unknown where the optimal femoral and tibial tunnel position is located in single-bundle (SB) ACL reconstruction. The purposes of this study were to analyze the knee kinematics with various graft positions and to propose the optimal graft position during SB ACL reconstruction. A musculoskeletal computer simulation was used to analyze knee kinematics. Four attachments on the femoral side (anteromedial [AM], mid, posterolateral [PL], and over-the-top positions) and three attachments on the tibial side (AM, middle, and PL positions) were determined. The middle-bundle attachment was placed at the midpoint of the AM and PL bundle attachments for the femoral and tibial attachments. SB ACL reconstruction models were constructed to combine each of the four femoral attachments with each of three tibial attachments. Kinematic comparison was made among a double-bundle (DB) model and 12 SB reconstruction models during deep knee bend and stair descent activity. The tunnel position of the tibia had greater effect of knee kinematics than that of the femur. AM tibial attachment models showed similar medial and lateral anteroposterior positions to the DB model for both activities. Axial rotation in the AM tibial attachment models was similar to the DB model regardless of the femoral attachment, whereas greater maximum axial rotation was exhibited in the PL tibial attachment models, especially during stair descent activity. AM tibial attachment can represent normal knee kinematics, whereas the PL tibial attachment can induce residual rotational instability during high-demand activities. The AM tibial tunnel is recommended for SB ACL reconstruction.
Theories explaining the relationship between neighbourhood stressors and depressive symptoms
Authors: Cho Seungjong 
Published: January 2022

AbstractThis study synthesizes the current theoretical knowledge to explain the relationship between neighbourhood stressors and depressive symptoms. The two most relevant sociological theories, social disorganization theory and stress process theory, are identified. The current study carefully reviewed the two theories regarding their historical development and key conceptual aspects, beginning with the theoretical evolution of research on neighbourhood stressors and mental health. This study also provides detailed critiques on each theory and suggests how researchers can apply both theories to their empirical testing. For example, social disorganization theory points out the application of both objective and subjective aspects of neighbourhood stressors. Also, the stress process theory emphasizes the mediating or moderating role of psychosocial resources. In conclusion, this study suggests a conceptual model of neighbourhood stressors, psychosocial resources, and depressive symptoms.
Cs diffusion mechanisms in UO2 investigated by SIMS, TEM, and atomistic simulations
Authors: Panetier C. , Pipon Y. , Gaillard C. , Mangin D. , Amodeo J. , Morthomas J. , Wiss T. , Benedetti A. , Ducher R. , Dubourg R. , Moncoffre N. 
Published: January 2022

Experimental investigations and atomistic simulations are combined to study the cesium diffusion processes at high temperature in UO2. After 133Cs implantation in UO2 samples, diffusion coefficients are determined using the depth profile evolution after annealing as measured by secondary ion mass spectrometry. An activation energy of 1.8 ± 0.2 eV is subsequently deduced in the 1300–1600 °C temperature range. Experimental results are compared to nudged elastic band simulations performed for different atomic paths including several types of uranium vacancy defects. Activation energies ranging from 0.49 up to 2.34 eV are derived, showing the influence of the defect (both in terms of type and concentration) on the Cs diffusion process. Finally, molecular dynamics simulations are performed, allowing the identification of preferential Cs trajectories that corroborate experimental observations.
Difference-frequency chirped-pulse dual-comb generation in the THz region: Temporal magnification of the quantum dynamics of water vapor lines by &gt;60 000
Authors: Stroud Jasper R. , Plusquellic David F. 
Published: January 2022

A new difference-frequency method based on electro-optic phase modulators (EOMs) and two free-running lasers is reported to perform chirped-pulse dual-comb spectroscopy in the THz region. A variation of a near-IR interleaving scheme we recently reported has been developed to interleave the EOMs’ orders and sidebands and to map THz comb teeth into the radio-frequency region below 1 MHz. The down-converted comb teeth are shown to have transform limited widths of 1 Hz over a 1 s time scale. The dual chirp-pulsed scheme is used to measure the complex line shapes of two water vapor lines below 600 GHz and to temporally magnify the effects of rapid passage by more than 60 000. For the 11,0 ← 10,1 transition in H2O, a pressure dependent phase perturbation is observed in the rapid passage response over the magnified time scale in contrast to a uniform line shape transformation observed for the 21,1 ← 20,2 transition of D2O. The possible origins for this anomalous behavior are modeled and discussed. The method is applicable to any region where difference or sum frequency waves can be generated.
X-ray absorption spectra of aqueous cellobiose: Experiment and theory
Authors: Akazawa Daisuke , Sasaki Takehiko , Nagasaka Masanari , Shiga Motoyuki 
Published: January 2022

The hydration structure of cellulose is very important for understanding the hydrolysis of cellulose at the molecular level. In this paper, we report a joint experimental and theoretical study on x-ray absorption spectroscopy (XAS) of aqueous cellobiose, a disaccharide unit of cellulose. In the experimental part, high resolution measurements of the carbon K-edge XAS spectra were taken. In the theoretical part, ab initio molecular dynamics simulations and ensemble calculations of electronic excited states were performed to obtain the continuous XAS spectra. The XAS spectra were found to have three characteristic peaks at 289.3, 290.7, and 293.6 eV, each representing the absorption by carbon atoms of the alcohol group, the hemiacetal group, and both of these functional groups. It was found that the peak heights in the spectrum change considerably over the temperature range of 25–60 °C, which is a reflection of the number of hydrogen bonds between cellobiose and water. We suggest that this spectral change could be useful information for identifying the hydration of cellulose in various environments.
Revisiting the link between magnetic properties and chemisorption at graphene nanoribbon zigzag edge
Authors: Wei Ziyang , Sautet Philippe 
Published: January 2022

Graphene has received tremendous interest in both chemical and physical fields. Among different edges of the graphene system, the zigzag edge terminated graphene nanoribbons (ZGNRs) show unique magnetic properties in the antiferromagnetic (AFM) state. However, to date, the understanding of ZGNR chemical properties is mainly based on the partial radical concept, and in previous studies, the energy differences between the ferromagnetic (FM) and AFM states are smaller than experimental evidence. Here, we report that the strongly constrained and appropriately normed functional gives a significantly larger energy difference, which matches the experimental observation. Furthermore, utilizing the energetics in the large difference case, we propose a conceptual supplement to the previous partial radical concept: the overall stabilization of the AFM state compared to the nonmagnetic (NM) state consists of two parts that affect the adsorption energy conversely. The NM-FM energy differences will strengthen the adsorption, being in line with the previous partial radical concept. The FM-AFM energy differences will instead weaken the adsorption. We perform calculations of H, OH, and LiS radical adsorption energies on ZGNRs to show that this weakening effect is numerically non-negligible: at least a ∼0.2 eV difference in the adsorption energies is found. We expect that this refinement of the partial radical concept can provide a more comprehensive understanding of the chemical properties of ZGNRs. The differences in adsorption energies for the H, OH, and LiS radicals found here lead to significant changes in the predicted reactivity of the ZGNR models.
A quantitative framework reveals traditional laboratory growth is a highly accurate model of human oral infection
Authors: Lewin Gina R. , Stocke Kendall S. , Lamont Richard J. , Whiteley Marvin 
Published: January 2022

SignificanceMost microbial knowledge comes from experiments in laboratory models, despite the assumption that these artificial systems alter microbial physiology relative the native environment. We tested this assumption for an oral pathogen,Porphyromonas gingivalis, using 93 metatranscriptomes from periodontally healthy and diseased patients and 122 transcriptomes from experimental models. We discovered that a simple in vitro model, midlogarithmic growth in rich media, highly recapitulatesP. gingivalisgene expression in the human oral cavity, outperforming other models, including a murine infection model. These results support the biological relevance of decades of laboratory experiments with this pathogen and validate an accessible experimental model for studyingP. gingivalisbiology. Furthermore, these data provide a conceptual framework for understanding in situ gene expression across microbes.
Facile fabrication of TiO2/Bi5O7Br photocatalysts for visible-light-assisted removal of tetracycline and dye wastewaters
Authors: Salmanzadeh-Jamadi Zahra , Habibi-Yangjeh Aziz , Pouran Shima Rahim , Xu Xuefei , Wang Chundong 
Published: January 2022

Abstract
The emergence of persistent organic pollutants such as dyes and pharmaceuticals in the aquatic environment has created drastic concerns worldwide due to their toxicity and potential hazards to the environment. Accordingly, non-stoichiometric TiO2/Bi5O7Br nanocomposites were prepared by stirring method as a visible-light-effective photocatalyst for degradation of amoxicillin (AMX) and tetracycline (TC), as antibiotic pollutants, and rhodamine B (RhB), methylene blue (MB), and malachite green (MG), as dye pollutants. The physiochemical properties of the samples were studied using FESEM, TEM/HRTEM, XRD, EDX, UV–vis DRS, FT-IR, XPS, BET, PL, photocurrent, and EIS analyses. The TiO2/Bi5O7Br (40%) photocatalyst performed superior to TiO2, Bi5O7Br, and TiO2/BiOBr (40%) in photodegradation of the studied contaminants. The degradation rate constants of AMX, TC, MG, RhB, and MB over the TiO2/Bi5O7Br (40%) photocatalyst were 18.2‒32.5 folds greater than pure TiO2, 1.6‒17.3 times higher than pure Bi5O7Br, and 1.4‒13 times larger than TiO2/BiOBr (40%), respectively. Quenching studies showed that superoxide anion radicals and holes had major roles in photocatalytic elimination of TC. Importantly, TiO2/Bi5O7Br (40%) nanocomposite showed robust reusability with high degree of TC removal after four successive photocatalytic recycles. This research introduces a cost-effective, efficient, and reusable visible-light-triggered binary system based on TiO2 for decontamination of medicinal and dye polluted wastewaters.
Superconductor–insulator transitions in three-dimensional indium-oxide at high pressures
Authors: Hen Bar , Shelukhin Victor , Greenberg Eran , Rozenberg Gregory Kh , Kapitulnik Aharon , Palevski Alexander 
Published: January 2022

Abstract
Experiments investigating magnetic-field-tuned superconductor–insulator transition (HSIT) mostly focus on two-dimensional material systems where the transition and its proximate ground-state phases, often exhibit features that are seemingly at odds with the expected behavior. Here we present a complementary study of a three-dimensional pressure-packed amorphous indium-oxide (InOx) powder where granularity controls the HSIT. Above a low threshold pressure of ∼0.2 GPa, vestiges of superconductivity are detected, although neither a true superconducting transition nor insulating behavior are observed. Instead, a saturation at very high resistivity at low pressure is followed by saturation at very low resistivity at higher pressure. We identify both as different manifestations of anomalous metallic phases dominated by superconducting fluctuations. By analogy with previous identification of the low resistance saturation as a ‘failed superconductor’, our data suggests that the very high resistance saturation is a manifestation of a ‘failed insulator’. Above a threshold pressure of ∼6 GPa, the sample becomes fully packed, and superconductivity is robust, with T
C tunable with pressure. A quantum critical point at P
C ∼ 25 GPa marks the complete suppression of superconductivity. For a finite pressure below P
C, a magnetic field is shown to induce a HSIT from a true zero-resistance superconducting state to a weakly insulating behavior. Determining the critical field, H
C, we show that similar to the 2D behavior, the insulating-like state maintains a superconducting character, which is quenched at higher field, above which the magnetoresistance decreases to its fermionic normal state value.
Radiation modulated spin coupling in a double-stranded DNA model
Authors: López Alexander , Varela Solmar , Medina Ernesto 
Published: January 2022

Abstract
The spin activity in macromolecules such as DNA and oligopeptides, in the context of the chiral induced spin selectivity has been proposed to be due to the atomic spin–orbit coupling (SOC) and the associated chiral symmetry of the structures. This coupling, associated with carbon, nitrogen and oxygen atoms in biological molecules, albeit small (meV), can be enhanced by the geometry, and strong local polarization effects such as hydrogen bonding. A novel way to manipulate the spin degree of freedom is by modifying the spectrum using a coupling to the appropriate electromagnetic radiation field. Here we use the Floquet formalism in order to show how the half filled band Hamiltonian for DNA, can be modulated by the radiation to produce up to a tenfold increase of the effective SOC once the intrinsic coupling is present. On the other hand, the chiral model, once incorporating the orbital angular momentum of electron motion on the helix, opens a gap for different helicity states (helicity splitting) that chooses spin polarization according to transport direction and chirality, without breaking time reversal symmetry. The observed effects are feasible in physically reasonable parameter ranges for the radiation field amplitude and frequency.