bluuebunny/crossref_metadata_2025_split huggingface dataset:
In‐Hospital Outcomes of Acute Myocardial Infarction With Essential Thrombocythemia and Polycythemia Vera: Insights From the National Inpatient Sample
Authors: Wu Jing , Fan YongZhen , Zhao Wei , Li Bing , Pan Naifan , Lou Zhiyang , Zhang Mingyou 
Published: December 2022

Background
Acute myocardial infarction (AMI) with essential thrombocythemia (ET) or polycythemia vera is rare, and there are scarce real‐world data on its management and impact on in‐hospital outcomes.

Methods and Results
Dates of current retrospective cohort study were obtained from the US National Inpatient Sample from October 2015 to 2019 for hospitalizations with AMI. The primary outcome was in‐hospital mortality, and the secondary outcome was major adverse cardiac or cerebrovascular events, stroke, and bleeding; major adverse cardiac or cerebrovascular event was defined by a composite of all‐cause mortality, stroke, and cardiac complications. Of the 2 871 934 weighted AMI hospitalizations, 0.27% were with ET and 0.1% were with polycythemia vera. Before propensity matching, AMI hospitalization with ET was associated with increased risk of in‐hospital mortality (7.1% versus 5.7%; odds ratio [OR], 1.14 [95% CI, 1.04–1.24]), major adverse cardiac or cerebrovascular events (12.6% versus 9%; OR, 1.36 [95% CI, 1.26–1.45]), bleeding (12.7% versus 5.8%; OR, 2.28 [95% CI, 2.13–2.44]), and stroke (3.1% versus 1.8%; OR, 1.66 [95% CI, 1.46–1.89]). Polycythemia vera was associated with an increased risk of in‐hospital mortality (7.8% versus 5.7%; OR, 1.21 [95% CI, 1.04–1.39]) and major adverse cardiac or cerebrovascular events (12.0% versus 9%; OR, 1.18 [95% CI, 1.05–1.33]). After propensity matching, ET was associated with increased risk of bleeding (12.6% versus 6.1%; OR, 2.22 [95% CI, 1.70–2.90]), and AMI with polycythemia vera was not associated with worse in‐hospital outcomes.

Conclusions
AMI hospitalization with ET is associated with high bleeding risk before and after propensity score matching, particularly for hospitalizations treated with percutaneous coronary intervention. The management of AMI requires a multidisciplinary and patient‐centered approach to ensure safety and improve outcomes.
Change in Depressive Symptoms During the First Month of Discharge and 1‐Year Clinical Outcomes in Patients Hospitalized for Heart Failure
Authors: Wang Bin , Lei Lubi , Zhang Haibo , Miao Fengyu , Zhang Lihua , Tian Aoxi , Li Jing 
Published: December 2022

Background
The patterns of depressive symptom change during the first month after discharge, as well as their prognostic implications, and predictors of persistent or new‐onset depressive symptoms are not well characterized.

Methods and Results
We included patients hospitalized for heart failure undergoing Patient Health Questionnaire‐2 before discharge and at 1 month after discharge in a multicenter prospective cohort. We characterized 4 patterns of change in depressive symptoms—persistent, new‐onset, remitted depressive symptoms, and no depressive symptom—and examined the associations between the 4 patterns and 1‐year clinical outcomes. We analyzed the factors associated with persistent or new‐onset depressive symptoms. A total of 4130 patients were included. Among 1175 (28.5%) symptomatic patients and 2955 (71.5%) symptom‐free patients before discharge, 817 (69.5%) had remission, and 366 (12.2%) had new‐onset depressive symptoms, respectively. Compared with no depressive symptom, persistent depressive symptoms were associated with an increased risk of cardiovascular death (hazard ratio [HR], 2.10 [95% CI, 1.59–2.79]) and heart failure rehospitalization (HR, 1.56 [95% CI, 1.30–1.87]); new‐onset depressive symptoms were associated with an increased risk of cardiovascular death (HR, 1.78 [95%CI, 1.32–2.40]) and heart failure rehospitalization (HR, 1.54 [95% CI, 1.29–1.83]). Remitted depressive symptoms were associated with a slightly increased risk of cardiovascular death but had no significant association with heart failure rehospitalization. Patients who were female or had poor socioeconomic status, stroke history, renal dysfunction, or poor health status had a higher risk of persistent or new‐onset depressive symptoms.

Conclusions
Sex, socioeconomic status, clinical characteristics, and health status help identify patients with high risks of depressive symptoms at 1 month after discharge. Dynamic capture of depressive symptom change during this period informs long‐term risk stratifications and targets patients who require psychological interventions and social support to improve clinical outcomes.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier (NCT02878811).
Increasing Compound Hazards of Tropical Cyclones and Heatwaves over Southeastern Coast of China under Climate Warming
Authors: Wang Pinya , Yang Yang , Xue Daokai , Qu Yi , Tang Jianping , Leung L. Ruby , Liao Hong 
Published: December 2022

Abstract
Compound hazards are more destructive than the individual ones. Using observational and reanalysis datasets during 1960–2019, this study shows a remarkable concurrent relationship between extreme heatwaves (HWs) over southeastern coast of China (SECC) and tropical cyclone (TC) activities over western North Pacific (WNP). Overall, 70% of HWs co-occurred with TC activities (TC–HWs) in the past 60 years. Although the total frequency of TCs over WNP exhibited a decreasing trend, the occurrences of TC–HWs over SECC have been increasing, primarily due to the increasing HWs in the warming climate. In addition, TC–HWs are stronger and longer lasting than HWs that occur alone (AHWs). And in the long-term perspective, both AHWs and TC–HWs exhibit increasing trends, especially since the mid-1980s. The enhancement on HWs caused by TC activities is sustained until TCs make their landfalls and then collapse. Based on composite analysis, TC activities enhance HWs by modulating atmospheric circulations and triggering anomalous descending motion over southern China mainland which intensifies the western Pacific subtropical high (WPSH) and favors increased temperatures therein. Given the severe adverse impacts of TC–HWs on coastal populations, more research is needed to assess the future projections of TC–HWs, as HWs are expected to be more frequent and stronger as the climate warms, whereas TCs over WNP may occur less often.
Right middle lobe syndrome after upper lobectomy: Role of the bronchial angle
Authors: Strollo Diane C , Donnenberg Vera S , Madan Shobhit , Moran Pauline L , Luketich James D , Sanchez Manuel Villa 
Published: December 2022

Background Right middle lobe syndrome is part of a spectrum of relatively rare but serious conditions that may occur following right upper lobectomy. We aimed to assess whether the preoperative middle lobe bronchial angle on CT predicted patients at risk of developing middle lobe syndrome. Method All patients who had a complete upper lobectomy over 4 years were retrospectively reviewed for clinical and imaging findings of middle lobe syndrome. Patients with previous lung surgery, preoperative chemo- or radiation therapy, or more extensive surgical resection were excluded. Patient demographics and symptoms, the surgical, pathologic and bronchoscopy reports, and pre- and post-operative chest imaging, to include 3D CT reconstructions and measurements of the middle lobe angles in a subset of patients, were retrospectively reviewed. Result One hundred and twenty-eight patients met inclusion criteria. Ten (8%) had middle lobe syndrome based on symptoms and imaging features. Eight had severe middle lobe consolidation. Two had postoperative onset of wheezing, with middle lobe bronchial abnormality on CT. The pre- and postoperative middle lobe bronchial angles of 14 patients without middle lobe syndrome were compared to 10 patients with middle lobe syndrome. The middle lobe bronchus was completely obliterated postoperatively and could not be determined in 1 patient. There was no significant difference between the pre- and postoperative angles in patients with or without middle lobe syndrome. Conclusion Middle lobe syndrome occurred in 8% of patients with right upper lobectomy. The preoperative middle lobe bronchial angle did not predict patients at risk for developing middle lobe syndrome.
Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults
Authors: Matuskey David , Gallezot Jean-Dominique , Nabulsi Nabeel , Henry Shannan , Torres Kristen , Dias Mark , Angarita Gustavo A , Huang Yiyun , Shoaf Susan E , Carson Richard E , Mehrotra Shailly 
Published: December 2022

Background: Centanafadine is an inhibitor of reuptake transporters for norepinephrine (NET), dopamine (DAT) and serotonin (SERT). Aims: This phase 1, adaptive-design positron emission tomography study investigated the occupancy time course of NET, DAT, and SERT and the relationship to centanafadine plasma concentrations. Methods: Healthy adult males received centanafadine sustained-release 400 mg/day for 4 days ( N = 6) or 800 mg in a single day ( N = 4). Assessments included safety monitoring; time course of occupancy of NET, DAT, and SERT; and centanafadine plasma concentrations. Results: Transporter occupancy was numerically higher for NET versus DAT or SERT. For NET, estimated (mean ± standard error [SE]) maximal observable target occupancy (TOmax) and concentration at half maximal occupancy (IC50) were 64 ± 7% and 132 ± 65 ng/mL, respectively, for all regions and 82 ± 13% and 135 ± 97 ng/mL after excluding the thalamus, which showed high nonspecific binding. For DAT and SERT, TOmax could not be established and was assumed to be 100%; estimated IC50 (mean ± SE) values were 1580 ± 186 ng/mL and 1,760 ± 309 ng/mL, respectively. For centanafadine, the estimated in vivo affinity ratio was 11.9 ± 6.0 (mean ± SE) for NET/DAT, 13.3 ± 7.0 for NET/SERT, and 1.1 ± 0.2 for DAT/SERT. DAT and SERT occupancies at a plasma concentration of 1400 ng/mL were estimated to be 47 and 44%, respectively. Conclusions: High occupancy at NET and moderate occupancy at DAT and SERT was observed at peak concentrations achieved following 400 mg total daily doses of centanafadine.
Cyclophosphamide exposure via sweat of patients receiving CHOP therapy
Authors: Miyazawa Maho , Yamashita Rina , Ichinohe Yui , Kohzai Yasuji , Kishimoto Keiko 
Published: December 2022

Introduction “Secondary exposure to anticancer drugs” refers to exposure to anticancer drugs after chemotherapy via the patient's urine and other excretions. The necessity of countermeasures against secondary exposure to anticancer drugs has been recently highlighted. Although anticancer drugs are also excreted through sweat, few studies have reported exposure to drug residues via this route. We investigated the amount of cyclophosphamide (CPA) excreted in the sweat of patients receiving CHOP therapy (cyclophosphamide, doxorubicin, vincristine, and prednisone). Methods The study population included eight patients with malignant lymphoma who received CHOP therapy between May and December 2021. The amount of CPA in their underwear (namely, cotton short-sleeved shirts) worn from the start of the CHOP therapy until 24 h after the end of CPA administration was measured, using liquid chromatography-mass spectrometry (LC-MS/MS). Results CPA was detected in the underwear of all the patients, with levels ranging between 7.38 and 160.77 ng/cm2. No subjective changes were observed in the sweating status of any patients during the study period. Conclusions These results suggested that patients’ sweat, as well as urine, is a potential route for exposure to anticancer drugs. Whether visibly contaminated or not, the clothing and linen worn directly by patients should be handled as a source of sweat-mediated exposure to anticancer drugs both in medical facilities and at home.
Textile-based weft knit strain sensor: Experimental investigation of the effect of stretching on electrical conductivity and electromagnetic shielding
Authors: Palanisamy Sundaramoorthy , Tunakova Veronika , Tunak Maros , Militky Jiri 
Published: December 2022

Recently, the research and development of textile-based sensors have attracted considerable attention. Changes in electrical conductivity (EC) and electromagnetic (EM) shielding effectiveness (SE) during external stimuli are the most frequently studied output. In this study, the EC and EM SE of an electro-conductive 1 × 1 rib knitted fabric made of metal-coated yarn were investigated during uniaxial and biaxial stretching. According to a theoretical survey, 2 main mechanisms are expected to influence the EC of the fabric under mechanical stress: the contact resistance at the junction of two yarns at low levels of applied force and the electrical resistance (ER) of yarn at high stress. Therefore, the electromechanical properties of single, single-loop, and multiloop yarns were also explored to explain the knitted fabric behavior during uniaxial and biaxial stretching. The SE of the knitted fabric varied from 63 to 47 dB based on the type and level of stretching. Using tests with yarns and crocheted chains, we confirmed that the effect of contact points and resistance on the entire ER textile unit prevails at low deformations. Further, the SE increased almost linearly with deformation during wale-wise stretching. The SE results correlate well with the ER values, which reflect the contact and longitudinal resistances of the knitted fabric. The higher the ER, the lower the SE. Notably, the porosity, which changes during stretching, needs to be considered in estimating SE. It was experimentally confirmed that the knit electro-conducite fabric could be used as a wireless strain sensors.
Determinants of anaemia prevalence in women of reproductive age in Nigeria: A cross-sectional study using secondary data from Nigeria Demographic and Health Survey 2018
Authors: Ogbuabor Daniel Chukwuemeka , Ogbuabor Alphonsus Ogbonna , Ghasi Nwanneka 
Published: December 2022

Background: Anaemia disproportionately affects women of reproductive age in sub-Saharan Africa including Nigeria. Yet, community-based studies on the prevalence and determinants of anaemia among women of reproductive age are scarce in Nigeria. Design: A cross-sectional community-based survey using a nationally representative sample. Objectives: This study described anaemia prevalence and its associated factors among women of reproductive age, pregnant women, and non-pregnant women in Nigeria. Methods: We analysed data from the 2018 Nigeria Demographic and Health Survey. Pregnant women with a haemoglobin level less than 11 g/dL and non-pregnant women with a haemoglobin level less than 12 g/dL were considered anaemic. Anaemia was also categorized as mild, moderate, and severe. Pearson’s chi-square test was used to evaluate the association between anaemia status and independent variables. All variables with ρ ⩽ 0.25 in bivariate analyses were further analysed using complex sample logistic regression. Results: Anaemia prevalence was 57.8%, 57.4%, and 61.1% for women of reproductive age, non-pregnant women, and pregnant women, respectively. The prevalence of severe anaemia was 1.6%, 1.5%, and 2.3% for overall women of reproductive age, non-pregnant women, and pregnant women, correspondingly. The southern regions, rural residence, low education, unemployment, low wealth index, and non-use of modern contraceptives significantly increased the likelihood of anaemia and severe anaemia among women of reproductive age and non-pregnant women. The likelihood of being anaemic was significantly increased by large family size among women of reproductive age and by being underweight among non-pregnant women. The South-East region, rural residence, low education, and unemployment were significantly associated with anaemia among pregnant women. The South-South region and unemployment increased the likelihood of severe anaemia among pregnant women. Short stature significantly reduced the odds of being anaemic and severely anaemic among pregnant women. Conclusions: Anaemia prevalence among all categories of women of reproductive age is high in Nigeria. Predictors of anaemia prevalence and severity should be considered in policies intended to reduce anaemia among women of reproductive age in Nigeria.
Achievement of more stringent disease control is associated with reduced burden on workplace and household productivity: results from long-term certolizumab pegol treatment in patients with psoriatic arthritis
Authors: Tillett William , Coates Laura C. , Kiri Sandeep , Taieb Vanessa , Willems Damon , Mease Philip J. 
Published: December 2022

Background: Psoriatic arthritis (PsA) impacts the physical health and functional ability of patients, leading to reduced productivity. High unemployment rates and absence due to sickness have been reported in patients with PsA. Objectives: This post hoc study investigated certolizumab pegol treatment impact on workplace and household productivity in patients with PsA, and assessed whether achievement of more stringent disease control was associated with greater improvements in productivity. Design: RAPID-PsA was a 216-week phase III trial. Methods: This post hoc study used a generalised estimating equations (GEE) model to examine the disease activity association, measured using American College of Rheumatology (ACR) and Disease Activity in PSoriatic Arthritis (DAPSA), and workplace and household productivity, assessed using an arthritis-specific Work Productivity Survey (WPS). The GEE model estimated the mean cumulative number of days patients meeting different disease control criteria were affected by absenteeism or presenteeism in the workplace and household. Results: In all, 273 patients were randomised to certolizumab pegol and 183 (67.0%) completed Week 216. At baseline, 60.8% of patients were employed outside the home. Improved disease control, measured using ACR and DAPSA criteria, was associated with fewer cumulative days affected by workplace absenteeism through Week 216: ACR70: 4.1 days, ACR50 to <70: 7.7, ACR20 to <50: 20.9, <ACR20: 35.7; DAPSA remission (REM): 3.3, low disease activity (LDA): 9.8, moderate disease activity (MoDA): 22.4, high disease activity (HDA): 54.0. Improved disease control was also associated with fewer days affected by workplace presenteeism: ACR70: 5.6, ACR50 to <70: 19.3, ACR20 to <50: 71.2, < ACR20: 141.2; DAPSA REM: 5.7, LDA: 25.8, MoDA: 77.2, HDA: 223.6. Similar associations between greater disease control and improved productivity were observed for household absenteeism and presenteeism. Conclusion: This post hoc study demonstrates the cumulative workplace and household work productivity benefits for patients with PsA when achieving more stringent thresholds of disease control with certolizumab pegol treatment.
A post-phenomenological analysis of using menstruation tracking apps for the management of premenstrual syndrome
Authors: Riley Sarah , Paskova Klara 
Published: December 2022

ObjectivesMenstruation tracking digital applications (MTA) are a popular technology, yet there is a lacuna of research on how women use this technology for the management of PMS. Theoretical frameworks for understanding users’ experiences are also underdeveloped in this nascent field. The objectives of the study were therefore twofold, to propose a theoretical framework for understanding women's use of MTA and apply it to the analysis of users’ experiences in the management of PMS.MethodA novel theoretical framework was proposed, informed by post-phenomenology, postfeminist healthism, feminist new materialism and digital health technologies as public pedagogy. This framework focuses analytic attention on affective relationships between subjectivity, bodily sensations, digital technology, and discourse. It was used to structure the analysis of five in-depth timeline interviews with women in Aotearoa New Zealand who experienced benefits from using MTA to manage PMS symptoms.ResultsThree pedagogical relationships were identified: a pedagogy of empowerment, where users learnt to control, predict and manage their PMS symptoms in line with healthism; a pedagogy of appreciation, where users learnt to understand their menstruating bodies as amazing, a valued part of them, and awe-inspiring that radically overturned past internalised stigma; and an ‘untrustworthy teacher’ who eroded this affirmative learning through inaccuracy, positioning users in dis-preferred categories, or being ‘creepy’.ConclusionsMTA offers huge possibilities for challenging menstrual stigma that need to be nurtured, developed, and protected; and there are benefits for analysing MTA within wider scholarship on postfeminist healthism.
Using motion capture technology to assess locomotor development in children
Authors: Bossavit Benoit , Arnedillo-Sánchez Inmaculada 
Published: December 2022

Objective Motor and cognitive development share biological background within the prefrontal cortex and cerebellum. Monitoring motor development is relevant to identify children at risk of developmental delays. However, access to timely assessment is prevented by its availability and cost. Affordable motion capture technology may provide an alternative to human assessment. Methods MotorSense uses this technology to guide and assess children executing age-related developmental motor tasks. It incorporates advanced heuristics informed by pattern recognition principles based on the developmental sequences of motor skills. MotorSense was evaluated with 16 4–6 year-old children from a rural primary school. Results A total of 506 jumps, 2415 steps and 831 hops were analysed. The analysis illustrates MotorSense Accuracy (MA), recognising jump forward (89.96%), jump high (83.34%), jump sideway (85.63%), hop (74.58%) and jog (92.34%), is as good as the sensor's precision. The analysis of the tasks’ execution shows a high level of agreement between human and MotorSense's assessment on jump forward (91%), jump high (99%), jump sideway (93%), hop (94%) and jog (92%). Conclusions MotorSense helps address the shortage of affordable technologies to support the assessment of motor development using graded age-related developmental motor tasks. Furthermore, it could contribute towards the tele-detection of motor developmental delays.
What does Dame Carol Black’s review of drug and alcohol misuse services mean for probation services?
Authors: Ball Kevin 
Published: December 2022

The Review of Drugs in two parts by Dame Carol Black (2020, 2021) has put new life into the case for properly resourcing substance misuse services in England and Wales. The Black Review has largely been accepted by the UK Government; Dame Carol’s analysis and recommendations have been the catalyst for additional funding and a renewed policy focus upon enforcement, treatment and prevention of drug misuse. Nevertheless, the Review has been criticised for focussing upon low-harm recreational drugs, for lacking consideration of co-occurring alcohol and drug misuse, and for accepting the Government’s restricted remit which excluded from consideration the harms of criminalisation and the ‘war on drugs’ (Transform Drugs, 2021). The following will summarise the Black Review, and the associated research and evidence. The article also attempts to elucidate key implications for probation, and the new opportunities for probation professionals to restore their ‘fractured relationship’ (Ball and Parker, 2022) with substance misuse colleagues.