bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research Trends on Ash Stabilization in the Pavement during 2002-2021
Authors: Hatami Amir Mostafa , Sabour Mohammad Reza , Joshaghani Alireza 
Published: May 2022

Abstract
Incineration ashes should be disposed of appropriately considering environmental issues. Ash stabilization in the pavement is an effective approach to reduce environmental impact and proper disposal. This study aimed to achieve a bibliometric analysis of “ash stabilization in pavement” research during 2002-2021, considering language, chronological trends, source types, subject areas, document types, affiliations, journals, countries, and author keywords. Also, Social Network Analysis was used for trends mapping and global collaborations determination among countries. The results exposed that the number of publications has been significantly increased by more than fourteenfold over the studied period. The United States, by 383 publications, was the leading country, followed by India and China. The most independent rate of the publications belonged to India, by 93.0%. The “Construction and Building Materials” published the most related articles, followed by “Journal Of Materials in Civil Engineering” and “Road Materials and Pavement Design.” Amongst the top ten productive institutes and organizations, four affiliations were from China, and three were from the United States. “Fly ash,” “compressive strength,” “durability,” “geopolymer,” “strength,” and “resilient modulus” had the most growth rate in recent years, based on the author keywords analysis. Besides, the increase of emerging keywords, “pervious concrete,” “reclaimed asphalt pavement,” and “lateritic soil” are noteworthy in the second half period.
Serum lipidomics reveals novel biomarkers by UHPLC-HRMS to assist the discrimination between colorectal adenoma and cancer
Authors: Chen Hongwei , Zhang Jiahao , Zhou Hailin , Zhu Yifan , Liang Yunxiao , Zhu Pingchuan , Zhang Qisong 
Published: May 2022

Abstract
Background: The mechanisms of colorectal adenoma (CA) transforming colorectal cancer (CRC) remain unclear, and there are still lacking biomarkers to distinguish CA from CRC. Hence, this study aimed to explore underlying the mechanisms of CA canceration and novel biomarkers to differentiate CA from CRC. Methods: An ultrahigh performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) method was employed to measure global lipid profiles of 100 serum samples from CA and CRC patients. Univariate and multivariate statistical analysis were applied to select the differential lipids between two groups. Combining constituent ratio analysis and performance evaluation analysis by the receiver operating characteristic (ROC) curve explored the mechanisms of CA canceration and lipid markers to discriminate CA and CRC.Results: Serum lipid profiles presented obvious differences between CA and CRC. Totally 85 differential lipids (P < 0.05 and fold change > 1.5) were discovered and mainly involved in fatty acid (FA), phosphatidylcholine (PC), and triacylglycerol (TAG) metabolism with ratio > 63%. 7 lipids served as the putative biomarkers with the area under the curve (AUC) > 0.800. Among them, a lipid panel containing four lipids was selected as the potential biomarkers with excellent performance (AUC = 0.971) and the highest selected frequency to distinguish CA from CRC based on SVM classification model.Conclusions: The lipid panel could act as the potential biomarkers aiding the early diagnosis of CRC. Metabolic dysregulation of FAs, PCs, and TAGs should be involved in CA canceration, which provides new clues to understand its underlying mechanisms.
Dynamic link between economic growth, tourism, inward FDI, environmental degradation in ASEAN countries: A fresh look at an old problem
Authors: Noor Sameena , Azam Muhammad , Nawaz Muhamad Atif , Awan Abdul Majid 
Published: May 2022

Abstract
This study aims to investigate the linkage among tourism, foreign direct investment (FDI), environmental degradation by carbon dioxide (CO2) emissions and economic growth in five countries from Association of Southeast Asian Nations (ASEAN) over 1995–2018. The outcomes of pooled mean group (PMG) estimator reveal that inward FDI and international tourism arrivals have a significantly positive influence on economic growth both in the short-run and the long-run. The association between growth and CO2 emissions is found negative and significant. The Granger causality result reveals that there is bidirectional causality between FDI and growth, tourism, and growth and FDI and tourism. A unidirectional causal link is found between CO2 emissions and growth, tourism and population and population and CO2 emissions. These findings suggest enhance more inward FDI, control environmental pollution, but also necessary to attract more tourists towards these countries, which in turn, generate revenue and boost up economic growth and development.
Deformation failure and acoustic emission characteristics of continuous graded waste rock cemented backfill under uniaxial compression
Authors: Chen Guan , Ye Yicheng , Yao Nan , Fu Fanghui , Hu Nanyan , Zhang Zhen 
Published: May 2022

Abstract
In order to study the effect of aggregate particle size on damage and failure of cemented backfill, uniaxial compression tests were carried out on waste rock cemented backfill with different Talbol particle size gradations using YZW-30A rock direct shearing instrument. The characteristic parameters of acoustic emission (AE) of the specimens during loading process were monitored, and the damage evolution and failure mode of waste rock cemented backfill with different particle size gradations were discussed. The results show that: With the increase of Talbol particle size gradation index n, the uniaxial compressive strength of backfill body first increased and then decreased, and the failure mode of backfill body gradually changed from shear failure to tensile failure. The cracks on the surface of specimens are more and damage is more serious with the increase of the gradation index n. With the increase of the Talbol gradation index n, AE energy rate is more active, and the cumulative AE energy rate is higher. The AE energy rate increases rapidly in the plastic development stage, and reaches maximum value before and after the peak stress, which can be used as the precursor to judge the failure of waste rock cemented backfill. According to the test results, the damage model and constitutive equations of waste rock cemented backfill with different Talbol particle size gradations are established, which can provide engineering guidance for filling mined-out areas with waste rock to ensure safe production of mines.
Cultural Adaptation and Validation of the SPICT-ESTM Instrument to Identify Palliative Care Needs in Chilean Older Adults
Authors: Farfán-Zúñiga Ximena , Zimmermann-Vildoso Melissa 
Published: May 2022

Abstract
INTRODUCTION: Chile presents a scenario of an aging population and increased life expectancy, leading to many older adults (OA) needing palliative care (PC) during the course of their illness. The SPICT-ESTM is an instrument used to clinically evaluate patients with advanced chronic illness (ACI) to detect PC needs. Validating this instrument in Chile will allow for early detection of OA at risk of clinical decline who require this care.OBJECTIVE: adapt and validate the SPICT-ESTM instrument to identify PC needs among OA in Chile.METHODOLOGY: study following quantitative design – cross-sectional, descriptive, and developed in three stages: cultural adaptation by expert judgment; preliminary test of the SPICT-ESCH instrument to evaluate reliability and application of the SPICT-ESCH in 292 patients, to determine internal consistency and stability of the instrument. This study was done between January 2019 and July 2021. Participants in the study were nurses and OA from 5 health centers in Santiago, Chile. This study was approved by the Ethics Committee of Universidad de los Andes.RESULTS: in the cultural adaptation with content validity, following expert judgment, all items were kept. Semantic modifications were made on only three of them. A Cronbach’s Alpha of 0.84 and a Lawshe coefficient of 84% were achieved, ranking this as an acceptable tool for application. The pilot for the new version in Chile, SPICT-ESCH, determined stability and consistency over time, with a Pearson correlation coefficient (ρ) of 0.9167 (p<0.0001). In the final application of the instrument, to fortify the psychometric evaluation (n=292) we identified 53.4% positive SPICT-ESCH. The logistical model via OR (<0.001) showed that the items predicted the positivity of the instrument. The internal consistency obtained was 0.8662, confirming a correlation and intercorrelation between items. 100% of nurses evaluated the SPICT-ESCH as a useful and feasible instrument. CONCLUSION: SPICT-ESCH includes all the relevant indicators for adequate clinical identification of PC needs among the Chilean OA population, who could Benefit from the early introduction of palliative support contributing to their quality of life.
Peri-conceptional folic acid supplementation: A Cross-Sectional study to Assess the Awareness, Knowledge, Use and Associated Factors Among Pregnant Women Attending Antenatal Care in a Secondary Health Care Facility, Southwest Region, Cameroon
Authors: Alemajo Confidence Atemnkeng , Halle-Ekane Gregory Edie , Nkengasong Elvis Ajabmoh , Asongalem Emmanuel Acha 
Published: May 2022

Abstract
Background
Neural tube defects(NTDs) are among the most common birth defects, contributing to miscarriages, infant mortality, severe congenital abnormalities and serious disabilities. The protective effect of peri-conceptional folic acid (PFA) supplementation in reducing the risk of NTDs and other adverse pregnancy outcomes has been scientifically confirmed.
Methods
A cross sectional study was conducted using a structured questionnaire administered to 393 pregnant women seeking routine antenatal care between February to April 2020. Multivariate logistic regression was used to model factors associated with awareness, knowledge, and use of PFA.
Results
Approximately 55% of women reported that they had heard of folic acid and only 6.1% had knowledge of folic acid (its benefit in preventing birth defects and the appropriate time to start using it). However, only 5.1% reported that they started using folic acid before pregnancy. Folic acid awareness showed a significant relationship with university education and above (OR = 4.30, 95% CI [2.60, 7.30], P < 0.001). There was also a significant difference in the odds of knowledge among those with university education and above (OR = 5.06, 95% CI [1.65, 19.0], P = 0.0076). There was a statistically significant difference in the odds of being aware and having knowledge of folic acid between women who had a history of folic acid education from a health care provider before pregnancy compared to those who did not, (OR = 23.7, 95% CI [4.84, 430], P = 0.002), (OR = 12.0, 95% CI [4.31, 35.1], P < 0.001) respectively. Even though women who planned their pregnancy (OR = 4.89, 95% CI [0.84, 93.9]), received pre-conceptional folic acid education (OR = 5.11, 95% CI [1.47, 18.7], and had a history of an unsuccessful pregnancy (OR = 2.61, 95% CI [0.86, 8.65], had higher odds of folic acid use, these relationships were not statistically significant.
Conclusion
These results supports the fact that women with a high level of education and those with pre-conceptional education from a health care provider are more likely to be aware and have knowledge of folic acid, though this does not translate into use. Antenatal and population based health educational strategies and campaigns by health care providers targeting pregnant and child bearing age women, especially those with low levels of educational may improve use.
Human umbilical cord-derived mesenchymal stem cells ameliorate experimental colitis by normalization of gut microbiota
Authors: Yang Fan , Ni Beibei , Liu Qiuli , He Fangping , Li Li , Zhong Xuemei , Zheng Xiaofan , Lu Jianxi , Chen Xiaoyan , Lin Huizhu , Xu Ruixuan , He Yizhan , Zhang Qi , Zou Xiaoguang , Chen Wenjie 
Published: May 2022

Abstract
Background Crohn's disease (CD) is a chronic nonspecific inflammatory bowel disease. Current CD therapeutics cannot fundamentally change the natural course of CD and therefore it is of great significance to find new treatment strategy for CD. Preclinical and clinical studies have shown that mesenchymal stromal cells (MSCs) are a promising therapeutic approach, However，the mechanism of MSC alleviating CD and how MSC affects gut microbes is still unclear and needs to be further elucidated. MethodsWe used 2,4,6-trinitrobenzenesulfonic acid (TNBS) to induce experimental colitis in mice, and analyzed the microbiota in the fecal samples, which come from the control group, the TNBS group and the TNBS+MSC group with fecal 16S rDNA sequencing. Subsequent analysis of alpha and beta diversity were all performed based on the rarified data. PICRUStII analysis was subsequently performed from 16S rRNA gene sequences to infer gut microbiome functions. ResultsMSCs treatment improved the TNBS-induced colitis by increasing survival rates, relieving symptoms. A distinct bacterial signature was found in the TNBS group that differed from the TNBS+MSC group and controls. MSC alleviated the increased activities of sulfur and riboflavin metabolism.Meanwhile some metabolisms such as biosynthesis of amino acids，lysine biosynthesis, sphingolipid metabolism，secondary bile acid biosynthesis were decreased in the TNBS group when compared with the control group and the TNBS+MSC group.ConclusionsMSC treatment could modulate the dysregulated metabolism pathways in mice with colitis, restoring the abnormal microbiota function to a normal situation as the control group.
Domains of competence in midwifery students:A basis for developing a competence assessment tool for Iranian undergraduate midwifery students
Authors: Firoozehchian Firoozeh , Zareiyan Armin , Geranmayeh Mehrnaz , Moghadam Zahra Behboodi 
Published: May 2022

Abstract
Background:Given the growing importance of competence-based midwifery education, this study was conducted to explain the domains of clinical competence in midwifery students. Methods: Qualitative approach and conventional content analysis were used in the design of the present study. The research setting included midwifery and nursing schools and hospitals and health centers affiliated to Tehran and Guilan universities of medical sciences in Iran. The target population consisted of undergraduate midwifery students in the fourth to eighth semesters of school, midwives working in hospitals and health centers, midwifery faculty members, and obstetricians. The participants were selected through purposive maximum variation sampling, which continued until data saturation. After in-depth semi-structured interviews, the content of the interviews was analyzed according to the steps proposed by Zhang & Wildemuth. Results: Twenty-four people participated in this study, including seven midwifery students, seven midwives, nine midwifery and reproductive and sexual health faculty members, and one obstetrician. The participants were aged 20-56 years and their mean age was 39.75 years. Their level of education varied from midwifery student to PhD. The mean work experience of the participants was 13.62 years and the mean duration of the interviews was 48 minutes. The analysis of the data obtained from the experiences of the participants led to the formation of the four categories of ethical and professional function in midwifery, holistic midwifery care, effective interaction, and personal and professional development, along with ten subcategories. Conclusion: The findings of the present study showed that clinical competence in midwifery students involves different domains that correspond well overall to the general definitions of clinical competence in different sources. These findings can be used as a basis for the design and psychometric assessment of a clinical competence assessment tool for undergraduate midwifery students.
Towards Precision Home Visiting: Results at Six Months Postpartum from a Randomized Pilot Implementation Trial to Assess the Feasibility of a Precision Approach to Family Spirit
Authors: Ingalls Allison , Rebman Paul , Martin Lisa , Kushman Elizabeth , Leonard Amanda , Cisler Aimee , Gschwind Ingrid , Brayak Amanda , Amsler Ann Marie , Haroz Emily E. 
Published: May 2022

Abstract
Background: Shared implementation challenges at scale in early childhood home visiting have led researchers to explore precision home visiting as a promising service delivery mechanism to better address families’ unique needs and build greater program efficiencies. This randomized controlled pilot study aimed to assess the acceptability of a precision approach to one home visiting model, Family Spirit® and explore potential differences between Precision Family Spirit (PFS) and Standard Family Spirit (Standard FS) on participant-home visitor relationship and maternal outcomes. Methods: Participants (N=60) were at least 14 years old, pregnant or within two months postpartum, and enrolled in Family Spirit. Four sites in Michigan were randomized 1:1 to deliver PFS (up to 17 core lessons plus up to 13 additional lessons as needed) or Standard FS (home visiting services as usual). Primary (program acceptability, participant satisfaction, home visitor-participant relationship quality, retention, adherence) and secondary (knowledge, quality of life, difficulty with parenting problems, substance use, depression, stress) outcomes at 6 months postpartum are presented. PFS participants only were assessed during home visits on a subset of secondary measures that informed which lessons they should receive. Results: Mothers in both groups reported positive program acceptability, satisfaction, and home visitor-participant relationships at 6 months postpartum. However, open-ended feedback from Standard FS participants indicates that some lesson content may not be applicable to all participants. At six months, retention was 82.3% for PFS and 66.7% for Standard FS, and adherence was 30.1% for PFS and 20.6% for Standard FS. Conclusions: Preliminary findings indicate that precision home visiting may be acceptable and feasible, yet more research is needed to understand its impact as an implementation strategy. Trial registration: ClinicalTrials.gov NCT03975530 (first posted on 05/06/2019)
“We start where we are”: A qualitative study of barriers and pragmatic solutions to the assessment and reporting of implementation strategy fidelity
Authors: Akiba Christopher F , Powell Byron J , Pence Brian W , Muessig Kate , Golin Carol E. , Go Vivian 
Published: May 2022

Abstract
Background: Fidelity measurement of implementation strategies is underdeveloped and underreported, and the level of reporting is decreasing over time. Failing to properly measure the factors that affect the delivery of an implementation strategy may obscure the link between a strategy and its outcomes. Barriers to assessing and reporting implementation strategy fidelity among researchers are not well understood. The aims of this qualitative study were to identify barriers to fidelity measurement and pragmatic pathways towards improvement. Methods: We conducted in-depth interviews among researchers conducting implementation trials. We utilized a theory-informed interview approach to elicit the barriers and possible solutions to implementation strategy fidelity assessment and reporting. Reflexive-thematic analysis guided coding and memo-writing to determine key themes regarding barriers and solutions. Results: Twenty-two implementation researchers were interviewed. Participants agreed that implementation strategy fidelity was an essential element of implementation trials and that its assessment and reporting should improve. Key thematic barriers focused on (1) a current lack of validated fidelity tools with the need to assess fidelity in the short term, (2) the complex nature of some implementation strategies, (3) conceptual complications when assessing fidelity within mechanisms-focused implementation research, and (4) structural issues related to funding and publishing. Researchers also suggested pragmatic solutions to overcome each barrier. Respondents reported using specification and tracking data in the short term until validated tools become available. Participants suggested that researchers with strategy-specific content expertise lead the way in identifying core components and setting fidelity requirements for them. Addressing the third barrier, participants provided examples of what pragmatic prospective and retrospective fidelity assessments might look like along a mechanistic pathway. Finally, researchers described approaches to minimize costs of data collection, as well as more structural accountability like adopting and enforcing reporting guidelines or changing the structure of funding opportunities. Discussion: We propose short- and long-term priorities for improving the assessment and reporting of implementation strategy fidelity and the quality of implementation research. Conclusions: A better understanding of the barriers to implementation strategy fidelity assessment may pave the way toward pragmatic solutions.
Perceiving the landscape of fear for a semi-sessile ecosystem engineer - induced defensive and facilitative responses in mussels can be related to dose and origin of chemical cues
Authors: Capelle Jacob 
Published: May 2022

Abstract
Phenotypic plasticity in defensive traits (inducible defences) are energetically costly and are a trade off between growth and safety. Mussels live in high risk environments and, being semi-sessile perceive information on this environment via chemical cues. We hypothesize that in a natural situation different cues are simultaneously present in a dose that informs about density and type of predator. First, it is identified if the magnitude of the induced defense of the mussels is directly related to the degree of the dose of the chemical. Second, it is investigated if there is a difference in response to stimuli from different origin, as perceived by the mussel via chemical cues released. Chemical cues from an increasing number of predators, injured/dead conspecifics, aggregating mussels at high turbulence, and a combination of these factors are all observed. A toolkit was developed to quickly assess effects of the presence of various cues using formation and subsequent detachment of byssus treads as inducible defence. Results show that mussels can distinguish between chemical cues released by different predators and threats, and adjust their defensive response accordingly, but also respond to cues that give rise to facilitation (i.e. aggregation). Results further suggest that mussels react to risk relative to the threat it poses. A higher density of crabs evoked an increase in byssal thread production and the presence of sea stars only evoked an inducible defence in combination with crushed mussels. Energy allocation to deal with a threat is thereby increased only when the treat is immediate.