bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structurall features of the pancreas in patients with type 1 diabetes mellitus
Authors: Ragimov M. R. , Nikonova T. V. , Babaeva D. M. , Vladimirova V. P. , Shestakova M. V. 
Published: July 2022

BACKGROUND: Observation of changes in the volume and size of the pancreas has a long history, however, the results of studies are still not unambiguous, the specific causes of changes in pancreatic volume, as well as their consequences, are not clear. According to some data, the decrease of pancreas volume in life expectancy is 35–45% in the population of patients with a long history of type 1 diabetes, and about 20–25% during the first year of the disease. Interestingly, in T1D in 20–45% of cases, the development of exocrine pancreatic insufficiency is noted, one of the manifestations of which is pancreatic atrophy, leading to a decrease in life expectancy.AIM: Assess the volume and size of the pancreas, as well as factors that can influence on their changes.MATERIALS AND METHODS: The study included 78 patients with type 1 diabetes mellitus, the control group consisted of 23 people without previously identified disorders of carbohydrate metabolism, comparable in age and anthropometric parameters with the study group. RESULTS: The volume and dimensions of the pancreas were statistically significantly less in patients with T1D than in the control group. In addition, the influence of the duration of T1D and the age of onset of the disease on these indicators has been proven.CONCLUSION: The volume and size of the pancreas in patients with T1D is less than in healthy individuals. It is necessary to study the effect of these changes on the function of the pancreas.
Real-time control of laboratory information system based on nonlinear programming
Authors: Lv Fei , Yu Junfang 
Published: July 2022

Abstract
In order to study the real-time control research of laboratory information system based on nonlinear programming, by analyzing the role played by the laboratory information management system (LIMS) in quality management, and the relationship with quality control, put forward the functions that LIMS should set up and possess in the management of controlled documents, processing of inspection data, etc., an accurate and reliable method to ensure the test results. It has been verified that the system can meet the performance requirements of 350 virtual concurrent users, its memory usage and CPU usage are within acceptable limits, the response time of important operations of each module of the system is within 3 s. The average memory consumption obtained from the test is 2.02 GB, and the average utilization rate of CPU is 66%. The two indicators basically meet the performance requirements of the system. The system can meet the performance requirements of the number of virtual concurrent users 350, both its memory occupancy and CPU utilization rate are in the acceptable range. It not only improves the accuracy of the sample processing results, but also reduces the labor intensity of the technicians, so that the laboratory expands the analysis function from the simple reporting function.
Tra gli Inferi e le stelle: un problema testuale nel mito di Orfeo in Virgilio (georg. 4,509) e il Leitmotiv astronomico nelle catabasi da Omero a Dante (con echi di Apollonio Rodio)
Authors: Boldrer Francesca 
Published: July 2022

Abstract
The article treats the presence of stars in terrestrial landscapes, in opposition to the Underworld and in connection to the topos of katabasis, above all in order to pursue in more depth a textual problem in the fabula Orphei of Vergil’s Georgics (4,509 astris / antris). The philological question is approached both on the basis of context and in relation to the descent into Hades of Aeneas, as well as in diachronic comparison with the earlier Homeric katabasis of Odysseus and the later otherworldly voyage of Dante in the Commedia. This internal and intertextual investigation reveals multiple functions of the celestial bodies in similar stories, as well as analogies between Homer, Vergil and Dante, linked by interests in nature and astronomy and by reciprocal influences. In fact, the Greek model and the Italian emulator seem to help clarify the contested passage in the Vergilian katabasis of Orpheus, while the Latin poet and Dante (who also share echoes of Apollonius Rhodius) rework a celestial detail already present in the νέκυια of Homer. Finally, both these classical authors, as well as Ovid, are subtly present at the ends of the three parts of the Commedia, each of which closes with the suggestive and symbolic image of “stars”, which evokes and renews an ancient tradition.
A New Emendation for matavitatau in Petronius’ Satyricon
Authors: Boggio Tiziano 
Published: July 2022

Abstract
In this paper I propose an emendation for a long-standing textual problem in the Satyricon. In the Cena Trimalchionis one of the freedmen, Niceros, recounts a bizarre story, culminating in a frightening encounter between him and a werewolf. In a desperate attempt to escape peril, Niceros draws his sword to repel horrific shadows and utters a sequence of eleven letters which has puzzled scholars for more than a century: matavitatau (Petron. Sat. 62.2). I propose a correction which hypothesizes the presence of a verb and an interjection, namely gladium strinxi et

matavi – tatae! –

umbras cecidi. I support my proposal by analyzing the intersections between literary genres and poetic texts in the Satyricon. After analyzing the meanings and nuances of tatae, I argue that the presence of such an exclamation is perfectly suitable for the situation of fear and danger that Niceros is experiencing. I suggest that Homer’s Odyssey and Vergil’s Aeneid offer decisive indications to make the presence of an interjection plausible. Niceros’ dreadful encounter with the werewolf recalls epic models, namely the descent of Odysseus and Aeneas into the Underworld. Finally, I suggest that Petronius portrays Niceros as a mythomaniac narrator who fails to appropriate the conventions of Latin and Greek epic poetry.
Arousal/Stress Effects of “Overwatch” eSports Game Competition in Collegiate Gamers
Authors: Kraemer William J. , Caldwell Lydia K. , Post Emily M. , Beeler Matthew K. , Emerson Angela , Volek Jeff S. , Maresh Carl M. , Fogt Jennifer S. , Fogt Nick , Häkkinen Keijo , Newton Robert U. , Lopez Pedro , Sanchez Barbara N. , Onate James A. 
Published: July 2022

Abstract
Kraemer, WJ, Caldwell, LK, Post, EM, Beeler, MK, Emerson, A, Volek, JS, Maresh, CM, Fogt, JS, Fogt, N, Häkkinen, K, Newton, RU, Lopez, P, Sanchez, BN, and Onate, JA. Arousal/stress effects of “Overwatch” eSports game competition in collegiate gamers. J Strength Cond Res 36(10): 2671–2675, 2022—To date, no physical response data are available for one of the most popular eSport games, Overwatch. The purpose of this investigation was to describe the stress signaling associated with competitive Overwatch play and to understand how acute hormonal responses may affect performance. Thirty-two male college-aged gamers (age: 21.3 ± 2.7 years; estimated time played per week: 18 ± 15 hours) completed the study. Subjects were randomly assigned to a 6-player team to compete in a tournament-style match. Salivary measures of cortisol and testosterone were collected immediately before (PRE) and after (POST) the first-round game, with the heart rate recorded continuously during the match. The mean characteristics were calculated for each variable and comparisons made by the skill level. Significance was defined as p ≤ 0.05. There were no differences in measures of salivary cortisol. A differential response pattern was observed by the skill level for testosterone. The low skill group displayed a significant increase in testosterone with game play (mean ± SD, testosterone PRE: 418.3 ± 89.5 pmol·L−1, POST: 527.6 ± 132.4 pmol·L−1, p < 0.001), whereas no change was observed in the high skill group. There were no differences in heart rate characteristics between skill groups. Overall, the average heart rate was 107.2 ± 17.8 bpm with an average max heart rate of 133.3 ± 19.1 bpm. This study provides unique physiological evidence that a sedentary Overwatch match modulates endocrine and cardiovascular responses, with the skill level emerging as a potential modulator.
Assessing the Relationship Between External Workloads and Noncontact Injuries During Summer Conditioning and Preseason Practice in National Collegiate Athletic Association Division 1 Football Players
Authors: Burghardt William P. , Pfeiffer Karin A. , Kuenze Chris 
Published: July 2022

Abstract
Burghardt, WP, Pfeiffer, KA, and Kuenze, C. Assessing the relationship between external workloads and noncontact injuries during summer conditioning and preseason practice in National Collegiate Athletic Association Division 1 football players. J Strength Cond Res 37(4): 816–822, 2023—The purpose of this study was to prospectively investigate the relationship between noncontact injuries and workload in collegiate football during summer conditioning and preseason training. Workload and noncontact injury data were collected over the summer conditioning and preseason practice periods for a Division 1 National Collegiate Athletic Association football team (n = 34). Seven- and 21-day exponentially weighted moving averages (EWMA) were calculated daily for each athlete. The acute:chronic ratio (A:C ratio) of these 2 measures was also calculated daily. Injury rates for noncontact injuries were calculated for both periods. Continuous variable modeling (panel logistic regression and restricted cubic spline) was used to assess the relationship of EWMA A:C ratio and noncontact injury using a 3-day lag period. Athletic exposures (AEs) were defined as individual sport training, practice, or competition sessions. Nine injuries were observed (6.97/1,000 AEs), with 4 injuries resulting in lost time (3.09/1,000 AEs). The mean EWMA A:C ratio was 0.92 ± 0.41 (95% confidence interval: 0.03–2.09). Both the panel logistic regression and the restricted cubic spline models showed a significant relationship between EWMA A:C ratio and noncontact injuries. However, the odds ratio (14.16) in the logistic regression had a very large standard error (14.51) and a wide 95% confidence interval (1.90–105.49). The restricted cubic spline model had a pseudo R
2 of 0.136. Injury occurrence at given EWMA ratio values was lower than reported in previous research. Although both continuous models demonstrated a significant relationship between the EWMA A:C ratio and subsequent noncontact injuries over the next 3 days, neither model had sufficient goodness of fit to warrant adoption at this time.
Optogenetic control of YAP cellular localisation and function
Authors: Toh Pearlyn J Y , Lai Jason K H , Hermann Anke , Destaing Olivier , Sheetz Michael P , Sudol Marius , Saunders Timothy E 
Published: July 2022

AbstractYAP, an effector of the Hippo signalling pathway, promotes organ growth and regeneration. Prolonged YAP activation results in uncontrolled proliferation and cancer. Therefore, exogenous regulation of YAP activity has potential translational applications. We present a versatile optogenetic construct (optoYAP) for manipulating YAP localisation, and consequently its activity and function. We attach a LOV2 domain that photocages a nuclear localisation signal (NLS) to the N‐terminus of YAP. In 488 nm light, the LOV2 domain unfolds, exposing the NLS, which shuttles optoYAP into the nucleus. Nuclear import of optoYAP is reversible and tuneable by light intensity. In cell culture, activated optoYAP promotes YAP target gene expression and cell proliferation. Similarly, optofYap can be used in zebrafish embryos to modulate target genes. We demonstrate that optoYAP can override a cell's response to substrate stiffness to generate anchorage‐independent growth. OptoYAP is functional in both cell culture and in vivo, providing a powerful tool to address basic research questions and therapeutic applications in regeneration and disease.
Using Geomarkers and Sociodemographics to Inform Assessment of Caregiver Adversity and Resilience
Authors: Shah Anita N. , Rasnick Erika , Bhuiyan Mohammad AN , Wolfe Chris , Bosse Dianna , Simmons Jeffrey M. , Shah Samir S. , Brokamp Cole , Beck Andrew F. 
Published: July 2022

BACKGROUND AND OBJECTIVES
A high level of caregiver adverse childhood experiences (ACEs) and/or low resilience is associated with poor outcomes for both caregivers and their children after hospital discharge. It is unknown if sociodemographic or area-based measures (ie, “geomarkers”) can inform the assessment of caregiver ACEs or resilience. Our objective was to determine if caregiver ACEs or resilience can be identified by using any combinations of sociodemographic measures, geomarkers, and/or caregiver-reported household characteristics.

METHODS
Eligible participants for this cohort study were English-speaking caregivers of children hospitalized on a hospital medicine team. Caregivers completed the ACE questionnaire, Brief Resilience Scale, and strain surveys. Exposures included sociodemographic characteristics available in the electronic health record (EHR), geomarkers tied to a patient’s geocoded home address, and household characteristics that are not present in the EHR (eg, income). Primary outcomes were a high caregiver ACE score (≥4) and/or a low BRS Score (&lt;3).

RESULTS
Of the 1272 included caregivers, 543 reported high ACE or low resilience, and 63 reported both. We developed the following regression models: sociodemographic variables in EHR (Model 1), EHR sociodemographics and geomarkers (Model 2), and EHR sociodemographics, geomarkers, and additional survey-reported household characteristics (Model 3). The ability of models to identify the presence of caregiver adversity was poor (all areas under receiver operating characteristics curves were &lt;0.65).

CONCLUSIONS
Models using EHR data, geomarkers, and household-level characteristics to identify caregiver adversity had limited utility. Directly asking questions to caregivers or integrating risk and strength assessments during pediatric hospitalization may be a better approach to identifying caregiver adversity.
Evolution of the combined effect of different irrigation solutions and activation techniques on the removal of smear layer and dentin microhardness in oval-shaped root canal – An in-vitro study
Authors: Shi Lu , Wan Jie , Yang Yunfei , Yao Ying , Yang Ruiming , Xie Wen 
Published: July 2022

The aim of this in vitro study was to evaluate the effect of three final irrigants, namely QMix, MTAD and EDTA, combined with three irrigation techniques, namely conventional needle irrigation (CNI), passive ultrasonic irrigation (PUI) and photon-induced photoacoustic streaming (PIPS), on smear layer removal, dentin mineral content and microhardness in oval-shaped canals. 130 decoronated premolars with single, oval root canals were equally divided into1 blank control group and 12 treatment groups (n=10) according to the final irrigation protocols. Roots in treatment groups were instrumented with ProTaper Gold to size F4 and subjected to final irrigation. Smear layer removal was assessed by using a four-level scoring system under an environmental scanning electron microscope. Energy dispersive X-ray spectroscopy was performed to measure the dentin mineral content. Dentin microhardness was measured by Knoop microhardness testing. Statistical analysis of the data was performed by using Kruskal-Wallis test, followed by Dunn’s post hoc test with Bonferroni correction. PUI- and PIPS-activated QMix and EDTA removed smear layer more effectively than MTAD groups (p<0.05). Regarding the dentin mineral content and microhardness, QMix groups yielded the least calcium (Ca), phosphorus (P) and Ca/P ratio, followed by EDTA groups and MTAD groups (p<0.05). QMix groups produced significantly lower dentin microhardness values and higher hardness reduction percentages than MTAD groups (p<0.05). Within the limitations of the present study, it was concluded that QMix and EDTA were superior to MTAD in smear layer removal, especially when activated by PUI and PIPS, but these agents produced more pronounced effect on dentin mineral content and microhardness than MTAD.
Guidelines for breast cancer treatment in Bosnia and Herzegovina
Authors: Hadžikadić-Gušić Lejla , Cerić Timur , Marijanović Inga , Iljazović Ermina , Koprić Dijana , Zorlak Anela , Tanović Mahira , Mekić-Abazović Alma , Šišić Ibrahim , Delić Una , Mustedanagić-Mujanović Jasminka , Aginčić Alija , Bećiragić Edin , Greene Frederick 
Published: July 2022

Breast cancer is the most common cancer among women. In Bosnia and Herzegovina, accurate data on the status of breast cancer are lacking due to the absence of a central registry. Multiple international guidelines imply that institutions that monitor breast cancer patients should have optimal therapeutic options for treatment. In addition, there have been several international consensus guidelines written on the management of breast cancer. Application of consensus guidelines have previously been demonstrated to have a positive influence on breast cancer care. The importance of specialty breast centers has previously been reported. As part of the 2021 Bosnian-Hercegovinian American Academy of Arts and Sciences (BHAAAS) conference in Mostar, a round table of multidisciplinary specialists from Bosnia and Herzegovina and the diaspora was held. All were either members of BHAAAS or regularly participate in collaborative projects. The focus of the consortium was to write the first multidisciplinary guidelines for the general management of breast cancer in Bosnia and Herzegovina. The grading system used is reported in Table 1. Statements without use of a grading system were considered standard clinical practice by our panel of experts (see Table 2). Guidelines were developed for each area of breast cancer treatment and management. These guidelines will serve as a resource for practitioners managing breast cancer in the Bosnia and Hercegovina region. This might also be of benefit to the ministry of health and any future investors interested in developing breast cancer care policies in this region of the world.
Comparitive evaluation of antimicrobial effectiveness of titanium oxide coatings on different types of ceramic brackets against Streptococcus mutans
Authors: Goud SV Ramesh , Singamani Raja , Bhaskar V , Kumaran M Kurunji , Arafat Mohammed , Duvvuri S N Reddy 
Published: July 2022

Nanomaterials are widely used in modern clinical dentistry. They improve various properties, such as antimicrobial properties, durability of materials. These particles do not exceed 100 nm, due to they obtain a better ratio between the surface and mass. Nanomaterials are used in many areas of dentistry, such as conservative dentistry, endodontics, oral, and maxillofacial surgery, periodontics, orthodontics, and prosthetics. One of the most important complications of fixed orthodontic treatment is enamel demineralization. Brackets and orthodontic accessories facilitate plaque accumulation and compromise oral hygiene maintenance which lead to an increase in oral bacteria count during orthodontic treatment. 30 MBT 0.022’’ monocrystalline ceramic brackets and 30 MBT 0.022’’ polycrystalline ceramic brackets (Metro Orthodontics) which are randomly divided into 4 groups: 2 control groups (group-1=15 uncoated monocrystalline and group-2=15 uncoated polycrystalline) and 2 experimental groups (group-3=15 silver oxide coated monocrystalline and group-4=15 silver oxide coated polycrystalline). S.mutans counts were significantly less in the experimental groups than control groups. Titanium oxide coatings on ceramic brackets reduced the colony forming units of S. mutans. Reduced number of colony forming units was seen in both the monocrystalline and polycrystalline coated brackets than their control groups.
Project-Based Learning: o caso da Feira de Negócios em Educação Física
Authors: Voltan Daniel Zonzini , Carvalho Beatriz Leme Passos 
Published: July 2022

Métodos ativos de ensino têm sido aplicados em diversas esferas da educação e seguramente é uma tendência, em especial no ensino superior. Dentre estes métodos encontra-se o Project-based Learning em que os alunos ganham conhecimento e habilidades trabalhando por um longo período de tempo para investigar e responder a uma pergunta, problema ou desafio autêntico, envolvente e complexo. A formação do profissional de Educação Física envolve o desenvolvimento de diversas competências relacionadas as áreas de humanas, biológicas e exatas. Uma importante competência exigida pelo mercado atual são as competências de administração e empreendedorismo.. Assim, o objetivo deste estudo é descrever a aplicação dos conceitos de administração, marketing e empreendedorismo no curso de graduação em Educação Física a partir do método ativo de ensino Project-based Learning. Esta pesquisa possui caráter qualitativo e caracteriza-se como Estudo de Caso de ensino da administração, com o intuito de compreender o como e o porquê do processo ensino-aprendizagem. Com a aplicação deste método foi possível desenvolver as competências das áreas do conhecimento, das habilidades, das emocionais e atitudinais. O engajamento dos alunos é muito maior quando estes veem um significado e principalmente utilidade para aquele conteúdo que estão aprendendo. E a conduta e atitude do professor é peça-chave no processo para potencializar a evolução dos alunos.
A Contrastive Research on the Digital Transformation of Sino-British Traditional Enterprises
Authors: Chai Peiyun 
Published: July 2022

<p>In the context of the rapid development of information technology, many domestic traditional enterprises have embarked on the road of transformation, upgrading and development to enhance their comprehensive competitiveness on the basis of excellent local culture. <span style="font-family: 'Times New Roman';">There are </span>many world-renowned brands and companies <span style="font-family: 'Times New Roman';">in Britain</span>, and on <span style="font-family: 'Times New Roman';">the basis of</span> its <span style="font-family: 'Times New Roman';">cultural </span>background, <span style="font-family: 'Times New Roman';">Britain</span> is regarded as the object of this <span style="font-family: 'Times New Roman';">contrastive research</span>. How to realize the development goal of enterprise digital transformation with the help of traditional culture has become one of the problems that enterprises need to solve. This article analyzes the comparison of the digital transformation of traditional enterprises in China and <span style="font-family: 'Times New Roman';">Britain</span>, in order to provide a reference for the steady development of traditional enterprises in the new era.</p>
Function and Limitation of Volunteer Organization -- Reflection on Dormitory Environment Construction Based on Game Theory
Authors: Zhang Ruixia , Wu Haishan , Tian Wang 
Published: July 2022

As we all know, college life is a buffer station for one to change from the role of a student to a socialized person.College
students spend at least half of their school time in dormitories, so dormitory environment has a huge impact on one’s physical and
mental health.The dormitory environment of most universities in China is not optimistic. On the one hand, some students do not
flush the toilet and throw rubbish into the washroom.Secondly, some students talk loudly during the break, which affects other
students’ rest.Thirdly, dormitory garbage is not thrown out in time, and the sorting trash can at the gate of school dormitory is
arranged.This paper mainly studies through the use of cooperative game theory to attract college students fall over each other to
participate in the volunteer organization, and then influence other students with poor self-restraint ability to change their behavior,
so as to improve the campus environment, and college students a healthy, clean and hygienic dormitory environment.