bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non‐coding RNA, a supreme post‐transcriptional immune regulator of bacterial or virus‐driven immune evolution in teleost
Authors: Haridevamuthu B. , Guru Ajay , Velayutham Manikandan , Snega Priya P. , Arshad Aziz , Arockiaraj Jesu 
Published: July 2022

AbstractThe global aquaculture boom, fuelled by a reduction in wild population and detection of novel viruses, has created a demanding market, hence, there is a pressing need to investigate the immune system of fish, further. As the most diverse community of vertebrates and a central contributor to the progressing global aquaculture market, teleost continues to draw vast scientific interest. Recent breakthroughs in multi‐omics technologies have provided a platform to understand the role of long non‐coding RNA (lncRNA) in the host immune system during infection. Emerging evidence shows that teleost lncRNA might have a regulatory role in immune responses, mostly through lncRNA–microRNA (miRNA) sponging. Teleost lncRNA shares a functionally active short sequence complement to target the miRNA which is conserved among the several fish species. Recent report suggests that rhabdovirus exploits a lncRNA in teleost and, to dodge the host immune mechanism and negatively regulate the immune system. This observation reveals the essentiality of lncRNA in pathogen‐driven immunity in teleost. Reports available on the function of teleost lncRNA are still in early stages and experimental verifications are a limiting factor. Unravelling the lncRNA‐mediated immune regulation in fishes could be used against the invading pathogens to strengthen the aquaculture production. This review elaborates on the experimentally identified and functionally characterized lncRNA and its regulatory role in the teleost immune response during infection and pathogen‐driven host immune evolution, which could eventually lead to achieving high standards in aquaculture productivity.
Genes and race in the era of genetic ancestry testing: The geneticization of identity and the social deconstruction of whiteness
Authors: Hunt Whitney , Merolla David M. 
Published: July 2022

AbstractThe link between racial identity and biology has long been a topic of fascination within the US popular imagination. After the completion of the Human Genome Project, this fascination has increased as journalists and others have continued to search for a genetic basis of racial classifications. Moreover, the increasing popularity of genetic ancestry testing (GAT) is spurring a geneticization of identity as individuals are encouraged to change their racial identity based on their genetic profiles, rather than their social location. Scholarship suggests white Americans are more likely to take GATs and change their identity based on results. This paper reviews the literature on links between race and genes and GAT. We argue that GAT is a racial project prompting white individuals to engage in an inverse process of constructing race, a process we call “the social deconstruction of whiteness.” That is, GATs allow white individuals to use the imprimatur of genetic science to claim alternative identities in an era where the socially constructed category of “white” is losing its salience and the history of white supremacy is becoming more widely recognized. This process could lead society from “racism without racists” and towards “white supremacy without whites.”
Reliability and Sensitivity of Nocturnal Heart Rate and Heart-Rate Variability in Monitoring Individual Responses to Training Load
Authors: Nuuttila Olli-Pekka , Seipäjärvi Santtu , Kyröläinen Heikki , Nummela Ari 
Published: July 2022

Purpose: To assess the reliability of nocturnal heart rate (HR) and HR variability (HRV) and to analyze the sensitivity of these markers to maximal endurance exercise. Methods: Recreational runners recorded nocturnal HR and HRV on nights after 2 identical low-intensity training sessions (n = 15) and on nights before and after a 3000-m running test (n = 23). Average HR, the natural logarithm of the root mean square of successive differences (LnRMSSD), and the natural logarithm of the high-frequency power (LnHF) were analyzed from a full night (FULL), a 4-hour (4H) segment starting 30 minutes after going to sleep, and morning value (MOR) based on the endpoint of the linear fit through all 5-minute averages during the night. Differences between the nights were analyzed with a general linear model, and intraclass correlation coefficient (ICC) was used for internight reliability assessments. Results: All indices were similar between the nights followed by low-intensity training sessions. A very high ICC (P < .001) was observed in all analysis segments with a range of .97 to .98 for HR, .92 to .97 for LnRMSSD, and .91 to .96 for LnHF. HR increased (P < .001), whereas LnRMSSD (P < .01) and LnHF (P < .05) decreased after the 3000-m test compared with previous night only in 4H and FULL. Increments in HR (P < .01) and decrements in LnRMSSD (P < .05) were greater in 4H compared with FULL and MOR. Conclusions: Nocturnal HR and HRV indices are highly reliable. Demanding maximal exercise increases HR and decreases HRV most systematically in 4H and FULL segments.
Albian–Cenomanian granitoid magmatism in Eastern and Central Tibet as a result of diachronous, continental collision induced slab tear propagation
Authors: Gao Xue , Dilek Yildirim 
Published: July 2022

AbstractA discrete belt of Albian–Cenomanian granitoid plutons occurs in the Lhasa and Qiangtang terranes in the Central (CTP) and Eastern Tibetan Plateau (ETP) and represents a major magmatic pulse in the plateau’s crustal evolution during the Cretaceous. The geochemistry, petrogenesis, and magmatic development of these granitoids are different from those of magmatic arc granitoids along the southern edges of the Lhasa and Qiangtang terranes, indicating different heat and melt sources and tectonic setting of their formation. We present here new mineral, whole-rock and isotope geochemistry, and zircon U-Pb age data from the Xiasai pluton in the ETP and discuss its geochemical-petrological characteristics and magmatic development in comparison to the other Cretaceous plutons in the ETP and CTP, and within the tectonic framework of the Mesotethyan geology of Tibet. Zircons from the Xiasai and other plutons in the ETP have yielded U-Pb ages ranging from 106 Ma to 93 Ma in comparison to 115 Ma and 100.3 Ma zircons from the Southern Qiangtang Terrane (SQT) and 113.4 Ma and 109 Ma zircons from the Northern Lhasa Terrane (NLT) farther west. The Cretaceous granitoids in the ETP and CTP range in composition from granite, K-feldspar granite to monzogranite and biotite monzogranite, representing highly fractionated I-type granites with relatively high SiO2 and K2O contents, variable (Na2O + K2O)/CaO and FeOT/MgO ratios, and (Zr + Nb + Ce + Y) abundances. They display significant negative Eu anomalies (Eu/*Eu) = 0.04–0.12) and strong depletions in Sr and Ba, and are strongly enriched in large ion lithophile elements but depleted in high field strength elements. Their εHf(t) values correspond to wide ranging Hf isotope crustal model ages (TDMC) of 0.3–1.9 Ga, and their Sr-Nd isotopic signatures show elevated (87Sr/86Sr)i ratios (0.7034–0.7105) and negative εNd(t) values of –8.8 to –4.9. These high whole-rock (87Sr/86Sr)i ratios and relatively high Th/Nb and Th/Yb ratios indicate incorporation of melts derived from partial melting of subducted sediments into the melt evolution of these granitoids that involved partial melting of the subduction-metasomatized lithospheric mantle and the mafic- to intermediate-composition continental crust. The extant zircon crystallization ages of the granitoid intrusions in the CTP and ETP show eastward younging of their emplacement from 115 Ma to 93 Ma, suggesting an apparent eastward migration of the heat source through time. A diachronous collision of the NLT with the SQT during 145–120 Ma and the subsequent slab breakoff induced, eastward propagated slab tear and asthenospheric upwelling produced the hybrid melts of the Albian–Cenomanian granitoids and their emplacement in a discrete, narrow magmatic belt in the CTP and ETP.
Case of reactive sacroiliitis possibly induced by an mRNA coronavirus disease vaccine
Authors: Roux Nicolas , Poussing Sophie , Maurier François 
Published: July 2022

A woman in her 30s received a second dose, first booster, Corminaty vaccine against the SARS-CoV-2. Three days later, the patient developed unilateral sacroiliitis. A pelvic scan revealed inflammatory joint edges, bone erosion and a heterogeneous mass of 2.5 cm in the psoas muscle. Joint puncture revealed no microcrystalline deposits, but bone marrow cells, erythroblast were identified. The standard bacterial cultures and culture for mycobacteria were negative. HLA B27 was negative, and no seroconversion was identified for HIV, Epstein-Barr virus, cytomegalovirus, chlamydia or Quantiferon. Two months later, the sacroiliitis resolved.The aetiologic approach of this erosive unilateral acute sacroiliitis in a person naïve to rheumatologic pathology was negative for inflammatory or infectious sacroiliitis. Arthralgias after vaccination are expected. Arthritis is less common, and acute sacroiliitis has not yet been described. Acute sacroiliitis may be considered a reactive sacroiliitis to the anti-COVID-19 mRNA vaccine.
Serious adverse event rates and reoperation after arthroscopic shoulder surgery: population based cohort study
Authors: Rees Jonathan L , Craig Richard , Nagra Navraj , Baldwin Mathew , Lane Jennifer C E , Price Andrew , Beard David J , Abram Simon , Judge Andrew , Prieto-Alhambra Daniel , Furniss Dominic , Carr Andrew J 
Published: July 2022

AbstractObjectiveTo provide clinicians and patients with accurate risk estimates of serious adverse events after common elective shoulder arthroscopic procedures, including reoperation within one year.DesignPopulation based cohort study.SettingHospital Episode Statistics for NHS England, including civil registration mortality data from the Office for National Statistics.Participants288 250 arthroscopic shoulder procedures performed in 261 248 patients aged ≥16 years between 1 April 2009 and 31 March 2017. Elective procedures were grouped into subacromial decompression, rotator cuff repair, acromioclavicular joint excision, glenohumeral stabilisation, and frozen shoulder release.Main outcome measuresThe primary outcomes were rates of serious adverse events (mortality, pulmonary embolism, pneumonia, myocardial infarction, acute kidney injury, stroke, and urinary tract infection) requiring inpatient care within 90 days post-surgery. Secondary outcomes were specific adverse event rates at 90 days, and reoperations (including for deep infection) within one year.ResultsThe overall rate of complications within 90 days after arthroscopic shoulder surgery (including reoperation) was low at 1.2% (95% confidence interval 1.2% to 1.3%), with one in 81 patients at risk, and varied according to type of procedure, from 0.6% (0.5% to 0.8%) for glenohumeral stabilisation to 1.7% (1.5% to 1.8%) for frozen shoulder release. After adjustment for age, comorbidities, and sex, no effect of procedure type was observed. Pneumonia was the most common adverse event (0.3%, 0.3% to 0.4%), with one in 303 patients at risk. Pulmonary embolic events were rare, at 0.1% (0.1% to 0.1%), with one in 1428 patients at risk. At one year, the overall rate for reoperation was 3.8% (3.8% to 3.9%), with one in 26 patients at risk, ranging from 2.7% (2.5% to 3.0%) for glenohumeral stabilisation to 5.7% (5.4% to 6.1%) for frozen shoulder release. The overall rate of further surgery for deep infection was low, at 0.1% (0.1% to 0.1%), with one in 1111 patients at risk, but was higher after rotator cuff repair (0.2%, 0.2% to 0.2%), with one in 526 patients at risk. Over the study period the number of arthroscopic shoulder procedures increased, except for subacromial decompression, which decreased.ConclusionsThe findings of this study suggest that risks of serious adverse events associated with common shoulder arthroscopy procedures are low. Nevertheless, serious complications do occur, and include the risk of reoperation in one in 26 patients within one year.Study registrationClinical.Trials.govNCT03573765.
Assessment of the non-communicable diseases kit for humanitarian emergencies in Yemen and Libya
Authors: Kiapi Lilian , Alani Ahmad Hecham , Ahmed Iman , Lyons Gemma , McLain Grace , Miller Laura , Darji Bhavika , Waweru Isaac , Aragno Mauricio , Kisarach Kelly , Zeleke Mekuanint , Nagi Nabeel , Jain Vageesh , Slama Slim 
Published: July 2022

Emergency health kits are a vital way of providing essential medicines and supplies to health clinics during humanitarian crises. The WHO non-communicable diseases (NDCs) kit was developed 5 years ago, recognising the increasing challenge of providing continuity of care and secondary prevention of NCDs and exacerbations, in such settings. Monitoring and evaluation of emergency health kits is an important process to ensure the contents are fit for purpose and to assess usability and utility. However, there are also challenges and limitations in collecting the relevant data to do so.This Practice paper provides a summary of the key methodologies, findings and limitations of NCD kit assessments conducted in Libya and Yemen. Methodologies included a combination of semistructured interviews, surveys with healthcare workers, NCD knowledge tests and quantifying the remaining contents.The kit was able to support the vital delivery of NCD patient care in some complex humanitarian settings and was appreciated by health facilities. However, there were also some challenges affecting kit use. Some kit contents were found to be in greater or lesser quantities than required, and medicine brands and country of origin affected acceptability. Supply chains were affected by the humanitarian situations, with some kits being held up for months prior to arrival. Furthermore, healthcare staff had received limited NCD training and were unable to dispense certain medicines, such as psychotropics, at the primary care level. Further granularity of kit modules, predeployment facility assessments, increased NCD training opportunities and a monitoring system could improve the utility of the kits.
Meta-analysis of COVID-19 prevalence during preoperative COVID-19 screening in asymptomatic patients
Authors: de Bock Ellen , Filipe Mando D , Simmermacher Roger K J , Kroese A Christiaan , Vriens Menno R , Richir Milan C 
Published: July 2022

ObjectivesPatients with COVID-19 may be asymptomatic and are able to transmit COVID-19 during a surgical procedure, resulting in increased pressure on healthcare and reduced control of COVID-19 spread. There remains uncertainty about the implementation of preoperative screening for COVID-19 in asymptomatic surgical patients. Therefore, this study aims to determine the prevalence of preoperative COVID-19, confirmed by reverse transcriptase PCR (RT-PCR), in asymptomatic patients.DesignSystematic review and meta-analysis.Data sourcesPubmed and Embase databases were searched through 20 February 2022.Eligibility criteriaAll COVID-19 articles including preoperative asymptomatic patients were included.Data extraction and synthesisTwo independent reviewers extracted data and assessed risk of bias. Meta-analysis was performed to determine the prevalence of COVID-19 with 95% CI. Moreover, estimated positive predictive value (PPV), negative predictive value, false-positives (FP) and false-negatives were calculated for preoperative asymptomatic patients.ResultsTwenty-seven studies containing 27 256 asymptomatic preoperative screened patients were included, of which 431 were positive for COVID-19 by RT-PCR test. In addition, the meta-analysis revealed a pooled COVID-19 prevalence of 0.76% (95% CI 0.36% to 1.59%). The calculated PPV for this prevalence is 40.8%.ConclusionsThe pooled COVID-19 prevalence in asymptomatic patients tested preoperatively was 0.76%, with low corresponding PPV. Consequently, nearly three-quarters of postponed surgical procedures in asymptomatic preoperative patients may be FP. In the event of similar pandemics, modification of preoperative mandatory RT-PCR COVID-19 testing in asymptomatic patients may be considered.
Have the COVID-19 pandemic and lockdown affected children’s mental health in the long term? A repeated cross-sectional study
Authors: Pustake Manas , Mane Sushant , Ganiyani Mohammad Arfat , Mukherjee Sayan , Sayed Misba , Mithbavkar Varada , Memon Zaid , Momin Abdus Samad , Deshmukh Krishna , Chordia Ayush , Parida Sabyasachi , Johnson Alan , Warghade Sanket , Varma Deepankar , Bhagwat Ajit 
Published: July 2022

ObjectiveThe study aimed to evaluate the impact of the COVID-19 pandemic on levels of anxiety and depressive symptoms in children and adolescents.DesignCross-sectional surveys were carried out on the mental health of children; one survey was conducted before the COVID-19 pandemic and one into the pandemic, 15 months after the school closures and implementation of lockdown and social distancing. Demographic data and COVID-19 pandemic-related data were collected from specific parent-report and self-report questionnaires.ParticipantsParticipants included children and adolescents between ages 6 and 16 years, attending a tertiary care hospital without any diagnosed major psychiatric or chronic disorder.AnalysisData were collected at two points (before the COVID-19 pandemic and during it) and compared. Levels of anxiety and depressive symptoms were compared and tested for statistically significant differences between these two points using appropriate statistical tests. Regression models were constructed to predict the factors affecting increased anxiety levels and depressive symptoms in the COVID-19 period.Results832 and 1255 children/adolescents were included in the study during the pre-COVID-19 and COVID-19 times, respectively. The median age of the participants was 10 years (IQR=4 years). The median (IQR) Spence Children’s Anxiety Scale score was 24 (12) at the pre-COVID-19 point and 31 (13) during the COVID-19 pandemic (p<0.001, r=−0.27). 11% and 16% of children reported being depressed at these two-time points, respectively (p=0.004, φc=−0.063). Regression analysis showed that many factors, including the duration of smartphone use, female gender and only child status, were associated with increased anxiety or depression levels.ConclusionA large proportion of children had elevated anxiety and depressive symptoms during the pandemic relative to before the pandemic, suggesting a need for measures to engage children in healthy habits to protect children’s mental health and continuous monitoring of children during such scenarios.
Randomised trials in maternal and perinatal health in low and middle-income countries from 2010 to 2019: a systematic scoping review
Authors: Eggleston Alexander John , Richards Annabel , Farrington Elise , Tse Wai Chung , Williams Jack , Sella Hewage Ayeshini , McDonald Steve , Turner Tari , Vogel Joshua P 
Published: July 2022

ObjectivesTo identify and map all trials in maternal health conducted in low and middle-income countries (LMIC) over the 10-year period from 2010 to 2019, to identify geographical and thematic trends, as well as comparing to global causes of maternal death and preidentified priority areas.DesignSystematic scoping review.Primary and secondary outcome measuresExtracted data included location, study characteristics and whether trials corresponded to causes of mortality and identified research priority topics.ResultsWe searched the Cochrane Central Register of Controlled Trials database, a combined registry of trials from multiple sources. Our search identified 7269 articles, 874 of which were included for analysis. Between 2010 and 2019, maternal health trials conducted in LMICs more than doubled (50–114). Trials were conducted in 61 countries—231 trials (26.4%) were conducted in Iran. Only 225 trials (25.7%) were aligned with a cause of maternal mortality. Within these trials, pre-existing medical conditions, embolism, obstructed labour and sepsis were all under-represented when compared with number of maternal deaths globally. Large numbers of studies were conducted on priority topics such as labour and delivery, obstetric haemorrhage and antenatal care. Hypertensive disorders of pregnancy, diabetes and health systems and policy—despite being high-priority topics—had relatively few trials.ConclusionDespite trials conducted in LMICs increasing from 2010 to 2019, there were significant gaps in geographical distribution, alignment with causes of maternal mortality and known research priority topics. The research gaps identified provide guidance and insight for future research conduct in low-resource settings.Trial registration number10.17605/OSF.IO/QUJP5.
Examining the effectiveness of psychological interventions for marginalised and disadvantaged women and individuals who have experienced gender-based violence: protocol for a scoping review
Authors: Yalcinoz-Ucan Busra , Zilney Laura , Zientarska-Kayko Agnes , Ireland Timothy , Browne Dillon Thomas 
Published: July 2022

IntroductionExposure to gender-based violence (GBV) has devastating psychological outcomes for victims/survivors. Particularly in conditions where GBV intersects with multiple forms of oppression, the negative impacts of violence are more challenging to overcome and potential pathways for recovery become less accessible. However, evidence regarding the availability and effectiveness of mental health interventions for GBV survivors from marginalised and disadvantaged communities has yet to be systematically integrated and synthesised. The proposed scoping review will examine the relevant literature regarding the availability and effectiveness of psychological interventions for survivors of GBV from marginalised and disadvantaged backgrounds. This review will (i) document what psychological interventions have been available and empirically established for marginalised and disadvantaged women and individuals with experiences of GBV, (ii) provide a narrative examination of the treatment outcomes of identified interventions regarding their effectiveness and (iii) examine the degree to which GBV interventions in selected sources are designed and applied with a recognition of the social determinants of mental health.Methods and analysisThe search for the proposed scoping review will include five electronic databases: PsycINFO, Scopus, Web of Science, Ovid Medline, and CINAHL. The database search will be completed in June 2022. An additional search will be conducted before the completion of the study in December 2022. The search will target research studies published after 2010. The primary eligibility criterion for study selection is having a focus on psychological interventions for GBV survivors from marginalised and disadvantaged groups. Two reviewers will conduct screening and data extraction. The data will be evaluated to map the treatment outcomes of interventions and their effectiveness. Implications for clinical services will be discussed.Ethics and disseminationNo ethical consideration is foreseen for this scoping review. The dissemination will be done through a publication in a top-tier open access journal and conference presentations.