bluuebunny/crossref_metadata_2025_split huggingface dataset:
The success of robot-assisted cystectomy in the treatment of muscle-invasive bladder cancer
Authors: Pavlov V. N. , Urmantsev M. F. , Bakeev M. R. 
Published: August 2022

Background. Bladder cancer is a serious problem of modern oncourology due to the annual increase in the number of diagnosed malignant neoplasms of the urinary system. High-risk muscle-invasive and non-muscle-invasive forms are subject to surgical treatment, while open radical cystectomy serves as the “gold standard”. Laparoscopic and robot-assisted radical cystectomy are serious competitors to this method. To date, the robotic method of removing the bladder is the least studied, despite the fact that it seems to be the most technologically advanced and modern.Aim. To analyze the own results of the use of robot-assisted interventions in high-risk musculoskeletal and non-musculoskeletal invasive bladder cancer, as well as to study the literature on the use of robot-assisted radical cystectomy in the treatment of malignant neoplasms of the bladder.Materials and methods. A prospective study was conducted on the basis of the clinic of the Bashkir State Medical University with the participation of 70 patients who were diagnosed with bladder cancer (T1–T4). The subjects underwent a robot-assisted radical cystectomy with various variants of urine derivation.Results. At the end of the study, the outcomes after robot-assisted radical cystectomy were analyzed and evaluated. The primary endpoints were 30- and 90-day complications of the Clavien–Dindo system. According to secondary indicators, robot-assisted radical cystectomy demonstrated a low duration of surgery, intraoperative blood loss.Conclusion. Robot-assisted radical cystectomy is a serious competitor to open and laparoscopic interventions for early and long-term perioperative indicators. This technique has shown its profitability in the treatment of bladder cancer, demonstrating a sufficient level of effectiveness and safety.
Prognostic significance of sPD-1/sPD-L1 in renal cancer depending on the phenotype of tumor and stromal cells
Authors: Kovaleva O. V. , Gratchev A. N. , Makarova E. I. , Bezhanova S. D. , Stilidi I. S. , Matveev V. B. , Kushlinskii N. E. 
Published: August 2022

Background. The search for new prognostic markers of renal cell carcinoma is an urgent problem of oncourology. Modern studies demonstrate the need for a comprehensive assessment of the clinical and prognostic significance of many markers.Aim is a comprehensive analysis of the prognostic significance of soluble forms of PD-1 and PD-L1 (sPD-1 and sPD-L1) depending on the phenotype of tumor cells and the microenvironment.Materials and methods. The study included tumor tissue and serum samples from 54 patients with renal cell cancer and from 67 healthy donors. The concentrations of sPD-1 and sPD-L1 were determined in blood serum using ELISA. Tissue expression of PD-L1, PU.1, CD3, and CD20 was assessed by immunohistochemistry. To determine statistically significant differences in independent groups, the Mann–Whitney test and Fisher’s exact test were used. Overall survival was analyzed by constructing survival curves using the Kaplan–Meier method. Differences were considered statistically significant at p <0.05.Results. Increase of sPD-L1 concentration in serum from patients with renal cell carcinoma compared with healthy donors was demonstrated. The highest concentration of the soluble form of the PD-1 receptor was observed in serum from patients with the non-clear cell renal cell carcinoma. High levels of sPD-L1 in serum and PD-L1 in tumor cells are associated with disease progression (advanced stage, higher malignancy, as well as the presence of regional metastases). It has been shown that the high content of PU.1+ and CD20+ cells in the tumor stroma are significant factors of unfavorable prognosis. No prognostic significance was found for both sPD-L1 and PD-L1 expressed in tumor tissue. However, analysis of a combination of these markers showed that the high concentration of sPD-L1 together with the high tissue expression of PD-L1 is an extremely unfavorable factor.Conclusion. Analysis of sPD-L1 concentration and tissue expression of PD-L1 in combination is a new approach for assessing the prognosis of renal cell carcinoma.
Еколого-естетичний підхід до дизайну об’єктів збору сміття в міському просто-рі
Authors: Рихліцька Оксана Дмитрівна , Косик Оксана Іванівна , Беззубцева Марія Сергіївна 
Published: August 2022

Розглядаються еколого-естетичні принципи створення місць збору сміття в сучасному міському просторі. Проаналізовано нові ідеї облаштування і дизайну смітників та контейнерів для побутових відходів в європейському та вітчизняному урбаністичному середовищі. Продемонстровано їх практичну та естетичну роль у міському ландшафті.В статті представлені останні розробки нових систем для зберігання і транспортування побутових відходів різного типу та затрати на їхнє впровадження в маштабах сучасного міста на прикладі міста Києва. Вирішення проблеми дизайну смітників у зоні міста має ряд переваг. В першу чергу це екологічна сторона питання. В естетично привабливу і функціональну урну сміття викидатимуть з більшою охотою. По друге — економічний аспект. Впроводження сучасних технологій в сферу зберігання та переробки побутових відходів позитивним чином позначиться на економіці міста і потребуватиме менше коштів на обслуговування системи збору, зберігання та переробки сміття. По третє — покращення естетичного вигляду смітників позитивним чином позначиться на розвитку туристичного бізнесу. Дизайн смітників, як і дизайн елементів благоустрою взагалі, пов’язаний за стилем виконання та матеріалами з візуальним характером відповідної громадської зони. Для збагачення простору тематичного середовища та посилення вражень можуть використовуватись креативні тематичні стилізовані смітники.
Análisis y evaluación de mercados internacionales de la miel natural
Authors: Castro Fajardo Hermes , Otálora Gómez Lina María , Chavarro Miranda Fernando 
Published: August 2022

La investigación tiene como objetivo clasificar los países para orientar la internacionalización de los productores de miel natural en Colombia al aplicarles la matriz de atractividad y competitividad, ya que el mercado actual exige a las empresas acciones que generen ventajas competitivas para enfrentar la creciente competencia internacional y aprovechar sus oportunidades. La matriz de atractividad y competitividad, aquí explicada, orienta la decisión acerca de a dónde y cómo entrar en mercados internacionales, para ello, se adaptó la matriz Boston Consulting Group (BCG) en sus ejes originales por el consumo per cápita y crecimiento del mercado para ubicar a los países objetivo en cuadrantes acordes con el ciclo de vida del producto (introducción, crecimiento, madurez y obsolescencia) o con ejes de consumo per cápita y precio aparente para ubicar las estrategias competitivas (liderazgo en costos, diferenciación y enfoque), lo que facilita el diseño de los planes de mercadeo internacional. La investigación muestra que Francia se posiciona como el mercado de mayor potencial para ser abordado con la posibilidad de los productores nacionales para ofrecer propuestas de valor basadas en la diferenciación y enfoque.
Pengembangan media pembelajaran biologi berbentuk buku saku dilengkapi peta konsep pada materi plantae siswa kelas x sma.
Authors: Elpina Nisi , Deswati Lisa , Sari Rona Taula 
Published: August 2022

<p>Penelitian ini bertujuan untuk menghasilkan buku saku yang dilengkapi dengan peta konsep materi plantae siswa kelas X yang valid dan praktis. Adapun yang melatarbelakangi penelitian ini adalah masih banyak siswa yang kurang aktif dalam proses pembelajaran serta hasil belajar siswa yang relatif rendah. Jenis penelitian ini adalah penelitian dan pengembangan yang merupakan metode penelitian yang digunakan untuk menghasilkan produk tertentu. Jenis penelitian ini menggunakan 3 tahapan model 4-D yaitu define, design, dan develop. Berdasarkan penelitian yang dilakukan, dihasilkan media pembelajaran biologi berupa buku saku yang dilengkapi dengan peta konsep sangat valid sebesar 3,67 oleh validator dan praktik oleh guru sebesar 83,75% dan oleh siswa sebesar 86% dengan kriteria praktik. Dan peneliti juga menyarankan agar peneliti lain dapat menjadikan penelitian ini sebagai referensi penelitian, sedangkan guru dan siswa dapat menjadikan buku saku ini sebagai salah satu sumber belajar.</p><p> </p><p><em><strong>Development of pocketbooks equipped with concept map on plantae material for high school students. </strong>This research aims to produce a pocket book equipped with a concept map on plantae material of valid and practical X grade students. As for the background of this research is that many students are still less active in the learning process as well as relatively low student learning outcomes. This type of research is research and development which is a research method used to produce certain products. This type of research uses 3 stages of 4-D models namely define, design, and develop. Based on the research conducted, produced biology learning media in the form of pocketbooks equipped with a very valid concept map of 3.67 by validators and practical by teachers by 83.75% and by students by 86% with practical criteria. And the researchers also suggested that other researchers could make this study a reference for research, while teachers and students could make this pocketbook as one of the learning sources.</em></p>
Can digital economic development facilitate employment growth? Empirical evidence from China
Authors: Huang Huan , Chen Yu-Xiang , Xiao Yi , Xiang Xin , Tang Xiao 
Published: August 2022

Abstract
With the gradual disappearance of the demographic dividend, the recurring world financial crisis, and the sudden outbreak of the new crown epidemic, a variety of complex factors have caused the Chinese job market to be under unprecedented pressure. In recent years, the development of the digital economy does not seem to be affected by the above factors. Can the fast-growing digital economy ease the current employment pressures facing China? In this paper, through the establishment of an index system of digital level of economic development, use of Chinese 30 provinces from 2011 to 2019, the digital economy data, calculate the annual digital economy development level of each province and explore the impact of digital economy development on employment. The findings show that the level of digital economy development is higher in the eastern coastal regions of China than in the western inland regions; through the development of the digital economy, the employment level can be effectively enhanced. This conclusion persisted after a series of robustness tests. The mechanism test finds that digital economy development affects the change of employment volume by influencing the level of education. Through further research, it is found that there is a threshold effect on the impact of the digital economy on employment in the central and eastern regions. This may be because there is a large variation in economic levels and an imbalance in education between the central and western regions, creating a certain amount of over-education. Finally, on the basis of the digital economy development and the current situation of employment of China now, this article from the perspective of the development of digital economy, education levels, improve some targeted suggestions are put forward.
Evaluation of the quality of multiple-choice questions according to the students' academic level
Authors: Iñarrairaegui Mercedes , Fernandez-Ros Nerea , Lucena Felipe , Landecho Manuel F , Garcia Nicolas , Quiroga Jorge , Herrero J. Ignacio Ignacio 
Published: August 2022

Abstract
Background. One of the most important challenges in medical education is the preparation of multiple-choice questions able to discriminate between students with different academic level. Average questions may be very easy for students with good performance, reducing their discriminant power in this group of students. The aim of this study was to analyze if the discriminative power of multiple-choice questions is different according to the students' academic performance. Methods. We retrospectively analyzed the difficulty and discrimination indices of 257 multiple-choice questions used for the end of course examination of pathophysiology and analyzed whether the discrimination indices were lower in students with good academic performance (group 1) than in students with moderate/poor academic performance (group 2). We also evaluated whether case-based questions maintained their discriminant power better than factual questions in both groups of students or not. Comparison of the difficulty and discrimination indices between both groups was based on the Wilcoxon test.Results. Difficulty index was significantly higher in group 1 (median: 0.78 versus 0.56; P < 0.001) and discrimination index was significantly higher in group 2 (median: 0.21 versus 0.28; P < 0.001). Factual questions had higher discriminative indices in group 2 than in group 1 (median: 0.28 versus 0.20; P < 0.001), but discriminative indices of case-based questions did not differ significantly between groups (median: 0.30 versus 0.24; P=0.296). Conclusions. Multiple-choice question exams have lower discriminative power in the group of students with high scores. The use of clinical vignettes may allow to maintain the discriminative power of multiple-choice questions.
Fixed Point Results in Soft Rectangular B-metric Space
Authors: Sonam Sonam , Chauhan C.S. , Bhardwaj Ramakant , Narayan Satyendra 
Published: August 2022

Abstract
The fundamental goal of the proposed work is to present the concept of soft rectangular b-metric space by generalising the notions of rectangular metric space and b-metric space, as well as to examine certain basic and topological aspects of the underlying spaces. Also, fixed point theorems for maps satisfying essential criteria in space are established, which generalises well known results in fixed point theory. In addition, some congruous examples are provided to clarify the concept of said space structure.Mathematics Subject Classification: 47H10, 54H25.
The first nonclassical Tc1 transposon discovered in yeast
Authors: Gao Shan , Chang Jia , Mi Dong , Yau Tung On , Liu Chang , Cui Jianlin , Xue Huaijun , Ruan Jishou , Bu Wenjun , Duan Guangyou 
Published: August 2022

Abstract
Background
Identification of transposons or retrotransposons is still a difficult task and can not be accomplished without specialist knowledge. Tc1/mariner is a superfamily of DNA transposons that have been discovered in animals, plants, and fungi. Tc1/mariner transposons are probably the most widespread DNA transposons in nature. However, Tc1 transposons have not been identified and characterized in yeast and their nucleotide sequences are not available in public databases.
Results
In the present study, we reported the discovery of two intact Tc1 transposons in yeast and. filamentous fungi, respectively. The first one, named Tc1-OP1, can be used as a signature of Ogataea parapolymorpha. The second one, named Tc1-MP1, represents a subfamlily of Tc1 transposons in Rhizopus, Mucor, Circinella, etc. Notablely, Tc1-OP1 may encode a protease and a transposase, challenging the classical model of DNA transposons.
Conclusions
Tc1-OP1 is the first reported Tc1 transposon in yeast. Tc1-OP1 and Tc1-MP1 can be used for the identification and characterization of Tc1 transposons in future studies. The discovery of Tc1-OP1 revealed a nonclassical model of DNA transposons, which could challenge and enrich fundamental concepts of DNA transposons.
Acceptability and Feasibility of a Mobile Health Application for Enhancing Public Private Mix for TB care among Healthcare workers in Southwestern Uganda
Authors: Tumuhimbise Wilson , Atwine Daniel , Kaggwa Fred , Musiimenta Angella 
Published: August 2022

Abstract
Background: Mobile health interventions can potentially enhance public-private linkage for tuberculosis care. However, evidence about their acceptability and feasibility is lacking.
Objective: To assess the initial acceptability and feasibility of a mobile health application for following up presumptive tuberculosis patients referred from private to public hospitals.
Methods: A total of 22 healthcare workers from three private hospitals and one public hospital in southwestern Uganda were trained and received Tuuka mobile application for a period of one month for testing. Testing focused on a variety of issues such as referring cases by private healthcare workers and receiving cases by public healthcare workers, and sending SMS reminders to the referred patients by filling the digital referral forms inbuilt within the app. Study participants participated in qualitative semi-structured in-depth interviews on the acceptability and feasibility of this app. An inductive, content analytic approach, framed by the unified theory of acceptance and use of technology model, was used to analyze qualitative data. Quantitative feasibility metrics and the quantitative assessment of acceptability were analyzed descriptively using STATA.
Results: Healthcare workers found the Tuuka application acceptable and feasible with a mean total system usability scale score of 98 (SD 1.97). The application was perceived to be useful in reminding referred patients to adhere to referral appointments, notifying public hospital healthcare workers about the incoming referred patients, facilitating communication across facilities, and enhancing patient-based care.
Conclusion: A mobile health application is acceptable and feasible for following up the referred presumptive tuberculosis patients referred from private to public hospitals in southwestern Uganda. Future efforts should focus on incorporating incentives to motivate and enable sustained use among healthcare workers.
Assessment of Resources for Quality Blocklaying, Bricklaying and Concreting Trade Option in Ogun State Technical Colleges
Authors: Raji Farouk Abiodun , Yisa Mukaila Abiodun 
Published: August 2022

Abstract
The study assesses the resources available in Ogun State Technical Colleges for quality block-laying, bricklaying, and concreting trade possibilities. Structured questionnaires were provided to 102 respondents, including 7 teachers, 2 technicians, and 93 students from eight (8) technical colleges in Ogun State that offer block-laying, bricklaying, and concreting trades. The Cronbach Alpha technique was used to estimate reliability. The alpha coefficient obtained was 0.71. A structured questionnaire and checklist were used to obtain information on availability, adequacy, and utilization. However, percentage and mean were used to analyze data obtained on the availability, adequacy, and utilization respectively. The results show that all of the required resources are available, but to varying degrees, ranging from very high to low; 2% are very highly available, 11.5% are highly available, 36.5% are moderately available, and 50% are poorly available quality block-laying, bricklaying, and concreting (BB&C) trade option in Ogun State Technical Colleges. Furthermore, the results suggest that 84.5% of the resources necessary are insufficient, 13.5% are adequate, and 2% are highly adequate. The findings also show that just 2 of the 14 pieces of equipment are frequently used, while the remaining 12 are only occasionally used. However, 22 of the 34 tools are frequently used, while the remaining 12 are only occasionally used. The study concluded that more funds should be injected into technical colleges to enable the provision of adequate tools and equipment for the implementation of technical education programs, and that personnel in Ogun State Technical Colleges should be sensitised to the importance of utilising available tools and equipment for quality block-laying, bricklaying, and concreting (BB&C) trade options.
Revisitando políticas latinoamericanas de género. Una operación histórica sobre las disrupciones genealógicas en los discursos de las cuotas femeninas del sur
Authors: Videla Hernán 
Published: August 2022

Desde finales del siglo XX Occidente, en pleno proceso de globalización y metamorfosis liberal del capitalismo, se mostró cuestionado profundamente por la ebullición de diferentes movimientos sociales que pondrían en crisis las tradicionales cosmovisiones políticas, organizativas y públicas de los estados. Dicho orden, probablemente el constructo clásico de las revoluciones modernas, comenzaba a verse resquebrajado por sectores marginados de la toma de decisiones.
En este contexto, las miradas políticas nacionales realizaron cierto giro programático hacia la periferia: Argentina se convirtió en el primer país del mundo en reconocer la asimetría patriarcal que el sistema político republicano había garantizado mediante sus principios liberales. Instrumentó una legislación específica que reivindicaba acciones positivas para obligar a los partidos políticos, otros grandes relictos de la modernidad occidental, a incorporar en sus listas militantes mujeres con posibilidades de resultar electas. Pronto, con desiguales variables, la región adheriría a esta praxis política.
Este trabajo pretende ofrecer un estudio histórico que refleje la problemática de la representación parlamentaria femenina en los ámbitos nacionales de determinados estados sudamericanos. Para ello se empleará una metodología cualitativa de carácter histórico entramada conceptualmente con los enfoques teóricos de la Historia Reciente y la Historia de Género.
Práctica y creación musical femenina en Santiago de Chile a mediados del siglo XIX. El caso de Delfina Pérez
Authors: Vera Malhue Fernanda 
Published: August 2022

Durante la segunda mitad del siglo XIX la creación y la práctica musical de repertorio de salón en contextos privados fue una actividad considerada como apropiada para la expresión artística de las mujeres burguesas de la época. En tanto prácticas, dialogaron con la literatura y la poesía y formaron parte del mismo modelo de educación ilustrado y moderno, y encontraron su lugar de expresión en el espacio semipúblico del salón.
El presente artículo busca poner en duda que Delfina Pérez fue el seudónimo artístico de Delfina de la Cruz, una mujer música chilena que vivió a mediados del siglo XIX. Mediante una revisión crítica de la prensa de la época, de las partituras conservadas en distintos archivos más el análisis de la historiografía musical que la menciona es que este artículo busca entregar las pruebas suficientes que permitan afirmar que a mediados del siglo XIX existieron en Chile dos mujeres llamadas Delfina que interpretaron y compusieron música bajo los cánones de la época. De manera específica, se busca visibilizar a Delfina Pérez como una mujer música y compositora profesionalmente activa durante casi toda la segunda mitad del siglo XIX.