bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Corporate Social Responsibility Terhadap Nilai Perusahaan dan Volume Perdagangan Saham (Studi pada Perusahaan Pertambangan Minyak dan Gas Yang Terdaftar Di Bursa Efek Indonesia Tahun 2017-2019)
Authors: Rahayu Alviya , Agustina Rachma 
Published: September 2022

Pengungkapan tanggungjawab sosial perusahaan atau sering disebut dengan Corporate Social Responsibility (CSR) merupakan informasi untuk menilai tingkat kepedulian perusahaan terhadap lingkungan. Kepedulian perusahaan terhadap lingkungan ini tentunya mengindikasikan perusahaan memiliki komitmen dan kemampuan dalam kinerja finansial.Tujuan penelitian ini untuk menguji pengaruh corporate social responsibility terhadap nilai perusahaan dan volume perdagangan saham. Populasi dalam penelitian di bursa efek indonesia perusahaan Pertambangan Minyak Dan Gas, ada 14 perusahan dan sempel yang diambil 10 perusahaan yang terdaftar di BEI, tempat penelitian di Bursa Efek Indonesia. Alat analisis dalam penelitian ini menggunakan regresi linear sederhana. Hasil penelitian ini menunjukkan bahwa corporate social responsibility tidak berpengaruh terhadap nilai perusahaan, dan corporate social responsibility tidak berpengaruh terhadap volume perdagangan saham.
Kata Kunci: Corporate Social Responsibility ; Nilai Perusahaan ; Volume Perdagangan Saham
Pouch failure in patients with ulcerative colitis
Authors: Achkasov S. I. , Kulikov A. E. , Mingazov A. F. , Vardanyan A. V. , Aleshin D. V. , Surovegin E. S. , Shahmatov D. G. , Sushkov O. I. 
Published: September 2022

AIM: to assess results of pouch surgery for ulcerative colitis (UC).PATIENTS AND METHODS: the retrospective single-center study included 144 patients who underwent J-pouch surgery in 2011–2018 (4 patients refused ileostomy closure due to nonmedical reasons and were excluded from analysis). Median follow-up was 32 (20; 43) months. The definition of «pouch failure» (PF) was clarified as a condition, when J-pouch associated complications do not permit ileostomy closure ≥ 12 months or more after pouch surgery.RESULTS: PF was detected in 30/140 (21.4%) cases and only in 8/140 (5,7%) patients pouch was removed. The most common complication identified by PF was pouch fistula, which was detected in 16/30 (53.3%) patients. Of the 30 patients with PF, 22 (73.3%) managed to “save” the pouch, of which — in 11/30 (36.7%) cases, anal defecation was restored, and in other cases — 11 (36. 7%) the ileostomy was not closed, but the pouch was preserved and is being treated conservatively. In 9/30 (30%) patients, the identified complications were performed by transanal removal of the remaining part of the rectum with the formation of a pouch-anal anastomosis, followed by closure of the ileostomy. In 8/30 (26.6%) cases pouch was removed. The multivariant analysis revealed hypoalbuminemia at the time of pouch surgery (OR = 5.74; 95% CI = 1.83–18.01; p = 0.003) as independent risk factors for PF.CONCLUSION: the only independent risk factor for complications which lead to PF was hypoalbuminemia. Multi-stage surgical treatment of complications associated with the pouch made it possible to “save” the ileal pouch in 22/30 (73.3%) cases, and completely overcome PF and restore anal defecation in 11/30 (36.7%) cases. In 8/140 (5.7%) patients, the pouch had to be removed and a permanent ileostomy was done.
Balloon dilation and electrodestruction for colorectal anastomosis strictures
Authors: Kachanova T. V. , Veselov V. V. , Vaganov Yu. E. , Mingazov A. F. , Shakhmatov D. G. , Likutov A. A. , Chernyshov S. V. , Sushkov O. I. 
Published: September 2022

AIM: to assess results of balloon dilatation (BD) and electric destruction (ED) for strictures of colorectal anastomoses.PATIENTS AND METHODS: the prospective cohort study included 69 patients with colorectal anastomotic strictures. Thirty-two of them underwent endoscopic balloon dilatation, 37 — electric destruction of scar tissue using a spherical monopolar electrode.RESULTS: the recurrence rate of the anastomotic stricture in the BD group was 3 times higher than after ED (OR = 2.9; 95% CI: 0.7–11.1; p = 0.04). The independent factor of stricture recurrence was the extent of stricture > 11 mm (OR = 11.8; 95% CI: 1,57–123,5; p = 0.02).CONCLUSION: electric destruction and balloon dilatation are effective and safe methods for strictures of colorectal anastomoses. The independent factor recurrence risk of the stricture was the extent of the scar narrowing more than 11 mm long.
Cost-effectiveness of the enhanced recovery program in patients undergoing colon surgery. Results of randomized clinical trial
Authors: Surovegin E. S. , Achkasov S. I. , Nazarov I. A. , Lukashevych I. V. , Sushkov O. I. 
Published: September 2022

AIM: to evaluate the cost-effectiveness of the enhanced recovery program (ERP).PATIENTS AND METHODS: a randomized clinical trial was carried out. A total of 152 patients were divided into ERP (n = 77) and conventional (n = 75) groups. To study the cost-effectiveness of ERP, direct medical costs were assessed at all stages of treatment (outpatient, inpatient, and also within 30 days after discharge from the hospital). Cost minimization analysis (CMA) was used.RESULTS: the median total costs at the stage of outpatient check-up ERP and conventional groups where comparable (33115-35146 rubles; p = 0.1). The total cost of inpatient treatment in the main group was 175,535 rubles, in the control group — 199,055 rubles (p < 0.0001). The costs of outpatient follow-up in ERP group were significantly higher compared to the conventional group (p = 0.0005). The difference, according to Hodges-Lehmann estimation, was 940.7 rubles. The cost of the entire cycle of treatment in the ERP group was 214805 rubles, in the conventional — 237890 rubles (p < 0.0001). Thus, the total reduction in treatment costs associated with ERP amounted to 23,085 rubles (9.7% expenditures)CONCLUSION: a cost-effectiveness analysis of the implementation of the Enhanced Recovery Program showed an overall cost reduction of 9.7% due to a reduction in costs at the inpatient stage.
Psychological rehabilitation of patients with colorectal cancer
Authors: Tkachenko G. A. , Kalashnikova I. A. , Musaev I. E. , Kuzmichev D. V. , Polinovskiy A. V. 
Published: September 2022

AIM: to work out the program for psychological support for patients with colorectal cancer and to evaluate its efficiency.PATIENTS AND METHODS: the prospective clinical psychological pilot study involved 26 patients who underwent surgery for colorectal cancer (after 6–12 months), aged 64.6 ± 7.1 year. The patients were divided into two groups: the main group included 12 patients who underwent psychotherapy and the control group with single consulting by the psychologist in order to fulfill the questionnaire (without psychotherapy). The psychological adjustment included cognitive behavioral psychotherapy and methods of neurofeedback. The efficiency assessment of the program for psychological adjustment was performed using the Hospital Anxiety and Depression Scale (HADS) before the rehabilitation and after its completion.RESULTS: the primary diagnostics showed that the anxiety of all patients in both groups was increased up to the subclinical level (8.6 ± 0.5 and 8.7 ± 0.2 points). Most patients of both groups initially demonstrated depressive symptoms of various severity degrees (83.3% and 85.7%). After the psychological adjustment, the anxiety level of the patient of the main group was reduced from 8.6 ± 0.5 to 7.5 ± 0.3 points (p = 0.052). In the control group, the anxiety level practically did not change (8.7 ± 0.2 and 8.2 ± 0.6 points) (p = 0.436). The quantitative analysis of the testing results showed that after the adjustment course including psychotherapeutic measures the number of patients who did not have depression in the main group definitely increased (41.7%). In the control group, the number of patients with depression was reduced less significantly from 85.7% to 71.4%.CONCLUSION: the anxiety-depressive condition is peculiar for patients with colorectal cancer 1 year after surgery and requires psychological support. The combination of cognitive behavioral psychotherapy and methods based on neurofeedback are effective psychological methods for these patients.
Comparison of techniques for left subclavian artery preservation during thoracic endovascular aortic repair: A systematic review and single-arm meta-analysis of both endovascular and surgical revascularization
Authors: Zhang Yuchong , Xie Xinsheng , Yuan Ye , Hu Chengkai , Wang Enci , Zhao Yufei , Lin Peng , Li Zheyun , Mo Fandi , Fu Weiguo , Wang Lixin 
Published: September 2022

BackgroundCurrently, the optimal technique to revascularize the left subclavian artery (LSA) during thoracic endovascular aortic repair (TEVAR) remains controversial. Our study seeks to characterize early and late clinical results and to assess the advantages and disadvantages of endovascular vs. surgical strategies for the preservation of LSA.MethodsPubMed, Embase and Cochrane Library searches were conducted under the PRISMA (Preferred Reporting Items for Systematic review and Meta-Analyses) standards. Only literature published after January 1994 was included. Studies reporting on endovascular revascularization (ER), surgical revascularization (SR) for LSA preservation were included. 30-day mortality and morbidity rates, restenosis rates, and rates of early and late reintervention are measured as outcomes.ResultsA total of 28 studies involving 2,759 patients were reviewed. All articles were retrospective in design. Single-arm analysis found no significant statistical differences in ER vs. SR in terms of 30-day mortality and perioperative complication rates. The mean follow-up time for the ER cohort was 12.9 months and for the SR cohort was 26.6 months, respectively. Subgroup analysis revealed a higher risk of perioperative stroke (4.2%) and endoleaks (14.2%) with the chimney technique compared to the fenestrated and single-branched stent approaches. Analysis of the double-arm studies did not yield statistically significant results.ConclusionBoth ER and SR are safe and feasible in the preservation of LSA while achieving an adequate proximal landing zone. Among ER strategies, the chimney technique may presents a greater risk of neurological complications and endoleaks, while the single-branched stent grafts demonstrate the lowest complication rate, and the fenestration method for revascularization lies in an intermediate position. Given that the data quality of the included studies were relatively not satisfactory, more randomized controlled trials (RCTs) are needed to provide convincing evidence for optimal approaches to LSA revascularization in the future.
Food plant diversity determines home range area and formation of a new family group of the world’s rarest primate
Authors: Wang Lu , Li Yousheng , Cui Jie , Zhang Hui , Gong Wenfeng 
Published: September 2022

Global primates are endangered, and thus it is important to know the determinants of primate population dynamics. It is widely reported that food plant diversity and nutrients are key determinants of many primate population dynamics. However, it remains unknown whether this can be applied to explain the population dynamics of Hainan gibbon (Nomascus hainanus), the world’s rarest primate. Recently, two individuals moved out from one family group (group C) and went across more than 9 km to form a new family group (group E), thus providing a perfect chance to quantify whether food plant diversity and nutrients can determine Hainan gibbon’s formation of the new family group. Here, we used a plot survey to compare the differences in food plant diversity (species richness and abundance) and nine leaf nutrient traits (leaf water content, total soluble sugar, vitamin C, calorific value, crude fat, crude protein, crude fiber, Zn, and Fe) between group C and group E. We found that plant diversity in group E was indeed higher (1.35–1.41 times) than that in group C. Moreover, in both groups C and E, food plant diversity within the home range was also higher (1.4–1.6 times) than that out of the home range. However, both cases could not be witnessed for all leaf nutrient traits. Results of principal component analysis revealed that food plant species between groups C and E were all significantly separated by food plant diversity but not leaf nutrient traits. Food plant species within and out of the home range of both groups C and E could also be significantly separated by food plant diversity, but not for all leaf nutrient traits. In conclusion, food plant diversity was one key determinant of the formation of a new family group of Hainan gibbons. Choosing high food plant diversity was also one key motivation for Hainan gibbons to select their home range.
Autonomic function predicts cognitive decline in mild cognitive impairment: Evidence from power spectral analysis of heart rate variability in a longitudinal study
Authors: Nicolini Paola , Lucchi Tiziano , Abbate Carlo , Inglese Silvia , Tomasini Emanuele , Mari Daniela , Rossi Paolo D. , Vicenzi Marco 
Published: September 2022

BackgroundDespite the emerging clinical relevance of heart rate variability (HRV) as a potential biomarker of cognitive decline and as a candidate target for intervention, there is a dearth of research on the prospective relationship between HRV and cognitive change. In particular, no study has addressed this issue in subjects with a diagnosis of cognitive status including cognitive impairment.ObjectiveTo investigate HRV as a predictor of cognitive decline in subjects with normal cognition (NC) or Mild Cognitive Impairment (MCI). Specifically, we tested the literature-based hypothesis that the HRV response to different physical challenges would predict decline in different cognitive domains.MethodsThis longitudinal study represents the approximately 3-year follow-up of a previous cross-sectional study enrolling 80 older outpatients (aged ≥ 65). At baseline, power spectral analysis of HRV was performed on five-minute electrocardiographic recordings at rest and during a sympathetic (active standing) and a parasympathetic (paced breathing) challenge. We focused on normalized HRV measures [normalized low frequency power (LFn) and the low frequency to high frequency power ratio (LF/HF)] and on their dynamic response from rest to challenge (Δ HRV). Extensive neuropsychological testing was used to diagnose cognitive status at baseline and to evaluate cognitive change over the follow-up via annualized changes in cognitive Z-scores. The association between Δ HRV and cognitive change was explored by means of linear regression, unadjusted and adjusted for potential confounders.ResultsIn subjects diagnosed with MCI at baseline a greater response to a sympathetic challenge predicted a greater decline in episodic memory [adjusted model: Δ LFn, standardized regression coefficient (β) = −0.528, p = 0.019; Δ LF/HF, β = −0.643, p = 0.001] whereas a greater response to a parasympathetic challenge predicted a lesser decline in executive functioning (adjusted model: Δ LFn, β = −0.716, p &lt; 0.001; Δ LF/HF, β = −0.935, p &lt; 0.001).ConclusionOur findings provide novel insight into the link between HRV and cognition in MCI. They contribute to a better understanding of the heart-brain connection, but will require replication in larger cohorts.
Effects of docosahexaenoic acid and eicosapentaoic acid supplementation on white matter integrity after repetitive sub-concussive head impacts during American football: Exploratory neuroimaging findings from a pilot RCT
Authors: Raikes Adam C. , Hernandez Gerson D. , Mullins Veronica A. , Wang Yiwei , Lopez Claudia , Killgore William D. S. , Chilton Floyd H. , Brinton Roberta D. 
Published: September 2022

ContextRepetitive sub-concussive head impacts (RSHIs) are common in American football and result in changes to the microstructural integrity of white matter. Both docosahexaenoic acid (DHA) and eicosapentaoic acid (EPA) supplementation exerted neuroprotective effects against RSHIs in animal models and in a prior study in football players supplemented with DHA alone.ObjectiveHere, we present exploratory neuroimaging outcomes from a randomized controlled trial of DHA + EPA supplementation in American football players. We hypothesized that supplementation would result in less white matter integrity loss on diffusion weighted imaging over the season.Design, setting, participantsWe conducted a double-blind placebo-controlled trial in 38 American football players between June 2019 and January 2020.InterventionParticipants were randomized to the treatment (2.442 g/day DHA and 1.020 g/day EPA) or placebo group for five times-per-week supplementation for 7 months. Of these, 27 participants were included in the neuroimaging data analysis (n = 16 placebo; n = 11 DHA + EPA).Exploratory outcome measuresChanges in white matter integrity were quantified using both voxelwise diffusion kurtosis scalars and deterministic tractography at baseline and end of season. Additional neuroimaging outcomes included changes in regional gray matter volume as well as intra-regional, edge-wise, and network level functional connectivity. Serum neurofilament light (NfL) provided a peripheral biomarker of axonal damage.ResultsNo voxel-wise between-group differences were identified on diffusion tensor metrics. Deterministic tractography using quantitative anisotropy (QA) revealed increased structural connectivity in ascending corticostriatal fibers and decreased connectivity in long association and commissural fibers in the DHA+EPA group compared to the placebo group. Serum NfL increases were correlated with increased mean (ρ = 0.47), axial (ρ = 0.44), and radial (ρ = 0.51) diffusivity and decreased QA (ρ = −0.52) in the corpus callosum and bilateral corona radiata irrespective of treatment group. DHA + EPA supplementation did preserve default mode/frontoparietal control network connectivity (g = 0.96, p = 0.024).ConclusionsThese exploratory findings did not provide strong evidence that DHA + EPA prevented or protected against axonal damage as quantified via neuroimaging. Neuroprotective effects on functional connectivity were observed despite white matter damage. Further studies with larger samples are needed to fully establish the relationship between omega-3 supplementation, RSHIs, and neuroimaging biomarkers.Trial registrationClinicalTrials.gov-NCT04796207
Structural and functional changes of bioactive proteins in donor human milk treated by vat-pasteurization, retort sterilization, ultra-high-temperature sterilization, freeze-thawing and homogenization
Authors: Liang Ningjian , Koh Jeewon , Kim Bum Jin , Ozturk Gulustan , Barile Daniela , Dallas David C. 
Published: September 2022

BackgroundDonor human milk should be processed to guarantee microbiological safety prior to infant feeding, but this process can influence the structure and quantity of functional proteins.ObjectiveThe aim of this study was to determine the effect of thawing, homogenization, vat-pasteurization (Vat-PT), retort sterilization (RTR) and ultra-high-temperature (UHT) processing on the structure of bioactive proteins in donor milk.MethodsPooled donor milk was either not treated (Raw) or treated with an additional freeze-thaw cycle with and without homogenization, Vat-PT, RTR with and without homogenization, and UHT processing with and without homogenization. Overall protein retention was assessed via sodium-dodecyl sulfate (SDS-PAGE), and the immunoreactivity of 13 bioactive proteins were assessed via enzyme-linked immunosorbent assay (ELISA).ResultsFreeze-thawing, freeze-thawing plus homogenization and Vat-PT preserved all the immunoglobulins (sIgA/IgA, IgG, IgM) in donor milk, whereas RTR and UHT degraded almost all immunoglobulins. UHT did not alter osteopontin immunoreactivity, but Vat-PT and retort decreased it by ~50 and 70%, respectively. Freeze-thawing with homogenization, Vat-PT and UHT reduced lactoferrin's immunoreactivity by 35, 65, and 84%, respectively. Lysozyme survived unaltered throughout all processing conditions. In contrast, elastase immunoreactivity was decreased by all methods except freeze-thawing. Freeze-thawing, freeze-thawing plus homogenization and Vat-PT did not alter polymeric immunoglobulin receptor (PIGR) immunoreactivity, but RTR, RTR plus homogenization and UHT increased detection. All heat processing methods increased α-lactalbumin immunoreactivity. Vat-PT preserved all the growth factors (vascular/endothelial growth factor, and transforming growth factors β1 and β2), and UHT treatments preserved the majority of these factors.ConclusionDifferent bioactive proteins have different sensitivity to the treatments tested. Overall, Vat-PT preserved more of the bioactive proteins compared with UHT or RTR. Therefore, human milk processors should consider the impact of processing methods on key bioactive proteins in human milk.
Establishment and validation of a radiological-radiomics model for predicting high-grade patterns of lung adenocarcinoma less than or equal to 3 cm
Authors: Dong Hao , Yin Lekang , Chen Lei , Wang Qingle , Pan Xianpan , Li Yang , Ye Xiaodan , Zeng Mengsu 
Published: September 2022

ObjectiveWe aimed to develop a Radiological-Radiomics (R-R) based model for predicting the high-grade pattern (HGP) of lung adenocarcinoma and evaluate its predictive performance.MethodsThe clinical, pathological, and imaging data of 374 patients pathologically confirmed with lung adenocarcinoma (374 lesions in total) were retrospectively analyzed. The 374 lesions were assigned to HGP (n = 81) and non-high-grade pattern (n-HGP, n = 293) groups depending on the presence or absence of high-grade components in pathological findings. The least absolute shrinkage and selection operator (LASSO) method was utilized to screen features on the United Imaging artificial intelligence scientific research platform, and logistic regression models for predicting HGP were constructed, namely, Radiological model, Radiomics model, and R-R model. Also, receiver operating curve (ROC) curves were plotted on the platform, generating corresponding area under the curve (AUC), sensitivity, specificity, and accuracy. Using the platform, nomograms for R-R models were also provided, and calibration curves and decision curves were drawn to evaluate the performance and clinical utility of the model. The statistical differences in the performance of the models were compared by the DeLong test.ResultsThe R-R model for HGP prediction achieved an AUC value of 0.923 (95% CI: 0.891-0.948), a sensitivity of 87.0%, a specificity of 83.4%, and an accuracy of 84.2% in the training set. In the validation set, this model exhibited an AUC value of 0.920 (95% CI: 0.887-0.945), a sensitivity of 87.5%, a specificity of 83.3%, and an accuracy of 84.2%. The DeLong test demonstrated optimal performance of the R-R model among the three models, and decision curves validated the clinical utility of the R-R model.ConclusionIn this study, we developed a fusion model using radiomic features combined with radiological features to predict the high-grade pattern of lung adenocarcinoma, and this model shows excellent diagnostic performance. The R-R model can provide certain guidance for clinical diagnosis and surgical treatment plans, contributing to improving the prognosis of patients.