bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a high-performance thin-layer chromatography densitometric method for the simultaneous determination of novel 1-acridinyl-1,2,3-triazole derivatives
Authors: Abdel-Hafez Gehan A. , Aboraia Ahmed S. , Mohammad Abdel-Mabood I. , Youssef Adel F. 
Published: September 2022

AbstractHigh-performance thin-layer chromatographic (HPTLC) method provides a simple, sensitive, and accurate analytical method for the simultaneous determination of certain synthesized 1-acridinyl-1,2,3-triazole derivatives without interference from starting materials and intermediates. Separation was carried out on Merck HPTLC silica gel 60F254 plates, using chloroform‒methanol (9:1, V/V) and hexane‒ethyl acetate (3:2, V/V) as mobile phases. Validation of the method was performed based on the basis of the International Council for Harmonisation (ICH) guidelines in terms of linearity, sensitivity, limit of detection, limit of quantification, precision, selectivity, and specificity. Least-square equations were calculated for the studied compounds in the ranges of 25–500 and 10–500 ng/spot for ultraviolet (UV) and fluorescence measurements, respectively. Correlation coefficients (r) values were found ranging from 0.9913 to 0.9992 for analytes. The method provides selectivity and specificity which ensure that synthesized compounds are in the pure form without the interference of starting materials and intermediates. The detection limits for the studied compounds ranged from 11.02 to 51.09 ng/spot and 3.84 to 31.95 ng/spot and quantification limits were 33.39–154.82 ng/spot and 11.63–73.67 ng/spot for both spectrophotometric and spectrofluorimetric methods, respectively, indicating applicability for good qualitative and quantitative determination of members of this series at the nanogram concentration levels in biological fluids.
Circular economy strategies for combating climate change and other environmental issues
Authors: Yang Mingyu , Chen Lin , Wang Jiangjiang , Msigwa Goodluck , Osman Ahmed I. , Fawzy Samer , Rooney David W. , Yap Pow-Seng 
Published: September 2022

AbstractGlobal industrialization and excessive dependence on nonrenewable energy sources have led to an increase in solid waste and climate change, calling for strategies to implement a circular economy in all sectors to reduce carbon emissions by 45% by 2030, and to achieve carbon neutrality by 2050. Here we review circular economy strategies with focus on waste management, climate change, energy, air and water quality, land use, industry, food production, life cycle assessment, and cost-effective routes. We observed that increasing the use of bio-based materials is a challenge in terms of land use and land cover. Carbon removal technologies are actually prohibitively expensive, ranging from 100 to 1200 dollars per ton of carbon dioxide. Politically, only few companies worldwide have set climate change goals. While circular economy strategies can be implemented in various sectors such as industry, waste, energy, buildings, and transportation, life cycle assessment is required to optimize new systems. Overall, we provide a theoretical foundation for a sustainable industrial, agricultural, and commercial future by constructing cost-effective routes to a circular economy.
Statistical Properties of a Virtual Cohort for In Silico Trials Generated with a Statistical Anatomy Atlas
Authors: La Mattina Antonino A. , Baruffaldi Fabio , Taylor Mark , Viceconti Marco 
Published: September 2022

AbstractOsteoporosis-related hip fragility fractures are a catastrophic event for patient lives but are not frequently observed in prospective studies, and therefore phase III clinical trials using fractures as primary clinical endpoint require thousands of patients enrolled for several years to reach statistical significance. A novel answer to the large number of subjects needed to reach the desired evidence level is offered by In Silico Trials, that is, the simulation of a clinical trial on a large cohort of virtual patients, monitoring the biomarkers of interest. In this work we investigated if statistical aliasing from a custom anatomy atlas could be used to expand the patient cohort while retaining the original biomechanical characteristics. We used a pair-matched cohort of 94 post-menopausal women (at the time of the CT scan, 47 fractured and 47 not fractured) to create a statistical anatomy atlas through principal component analysis, and up-sampled the atlas in order to obtain over 1000 synthetic patient models. We applied the biomechanical computed tomography pipeline to the resulting virtual cohort and compared its fracture risk distribution with that of the original physical cohort. While the distribution of femoral strength values in the non-fractured sub-group was nearly identical to that of the original physical cohort, that of the fractured sub-group was lower than in the physical cohort. Nonetheless, by using the classification threshold used for the original population, the synthetic population was still divided into two parts of approximatively equal number.
Back to the Control Room: Managing Artistic Work
Authors: Reeves Stuart , Greiffenhagen Christian , Perry Mark 
Published: September 2022

AbstractControl rooms have long been a key domain of investigation in HCI and CSCW as sites for understanding distributed work and fragmented settings, as well as the role and design of digital technologies in that work. Although research has tended to focus mainly on ‘command and control’ configurations, such as rail transport, ambulance dispatch, air traffic and CCTV rooms, centres of coordination shaped by artistic and performative concerns have much to contribute. Our study examines how a professional team of artists and volunteers stage manage and direct the performance of a mixed reality game from a central control room, with remote runners performing live video streaming from the streets nearby to online players. We focus on the work undertaken by team members to bring this about, exploring three key elements that enable it. First, we detail how team members oriented to the work as an artistic performance produced for an audience, how they produced compelling, varied content for online players, and how the quality of the work was ongoingly assessed. Second, we unpack the organisational hierarchy in the control room’s division of labour, and how this was designed to manage the challenges of restricted informational visibility there. Third, we explore the interactional accomplishment of the performance by looking at the role of radio announcements from the event’s director to orchestrate how the performance developed over time. Announcements were used to resolve trouble and provide instructions for avoiding future performative problems; but more centrally, to give artistic direction to runners in order to shape the performance itself. To close we discuss how this study of a performance impacts CSCW’s understandings of control room work, how the problem of ‘diffuse’ tasks like artistic work is co-ordinated, and how orientations towards quality as an artistic concern is manifest in / as control room practices. We also reflect on hierarchical and horizontal control room arrangements, and the role of video as both collaborative resource and product.Graphical abstract
Choice, Negotiation, and Pluralism: a Conceptual Framework for Participatory Technologies in Museum Collections
Authors: Hansson Karin , Dahlgren Anna Näslund 
Published: September 2022

AbstractIn an era of big data and fake news, museums’ collection practices are particularly important democratic cornerstones. Participatory technologies such as crowdsourcing or wikis have been put forward as a means to make museum collections more open and searchable, motivated by a desire for efficiency but also as a way to engage the public in the development of a more diverse and polyphonic heritage. However, there is a lack of a nuanced vocabulary to describe participatory technologies in terms of democracy. Without a deeper understanding of how technology shapes the overall structures, there is a risk that the tools instead undermine democratic ambitions.Addressing the need to conceptualize democracy in these contexts, we therefore develop a framework for participatory technologies with an eye toward the long-term development and preservation of cultural heritage. In this framework different democratic processes intersect with democratic values, from a liberal conception of democracy to a more deliberative democracy, to an agonistic pluralism emphasizing the importance of acknowledging conflict and diversity.To firmly ground our vocabulary in museum collection practices, we have investigated two cases from museums in the US that have opposite participatory strategies for enriching images with metadata; the Smithsonian Transcription Center, and the National Gallery of Art collection on Wikimedia Commons. These cases demonstrate how the framework can be used to identify patterns of participation showing the support for different values and processes.Furthermore, our conceptual investigation points out a contradiction in Human–Computer Interaction (HCI) research, between the pluralism and conflicts emphasized in more critical and participatory design perspectives used in the development of design, and the features in the actual design of participatory technologies, emphasizing consistency and access.
Systematizing core properties of pairing-based attribute-based encryption to uncover remaining challenges in enforcing access control in practice
Authors: Venema Marloes , Alpár Greg , Hoepman Jaap-Henk 
Published: September 2022

AbstractAttribute-based encryption (ABE) cryptographically implements fine-grained access control on data. As such, data can be stored by an entity that is not necessarily trusted to enforce access control, or an entity that is not even trusted to have access to the plaintext data at all. Instead, access control can be externally enforced by a trusted entity. Additionally, some multi-authority variants of ABE—which do not have a central authority—can effectively and securely implement access control in multiple-domain settings. Furthermore, ABE is the only cryptographic approach to fine-grained access control that does not require an online trusted third party during access requests, and thus provides better availability properties. The actual realization of these theoretical advantages in practice depends on whether current state-of-the-art ABE schemes support the necessary core properties. Much progress has been made in the last two decades in pairing-based ABE schemes, owing to their versatility and efficiency. In fact, it is possible to support most core properties under strong security guarantees, while incurring acceptable storage and computational costs. It is therefore a good time to ask ourselves whether pairing-based ABE has reached its full practical potential. To answer this question, we provide a comprehensive systematized overview of various existing pairing-based ABE schemes and their core properties. We also investigate the relationship between these core properties and real-world access control requirements. We show that a few challenges remain, that must be overcome for ABE to reach its full potential as a mechanism to implement efficient and secure access control in practice.
Reliability of electromyography during 2000 m rowing ergometry
Authors: Gee Thomas I. , Mulloy Franky , Gibbon Karl C. , Stone Mark R. , Thompson Kevin G. 
Published: September 2022

Abstract
Purpose
This study aimed to investigate the reliability of surface electromyography (EMG) assessed at seven muscles during three repeated 2000 m rowing ergometer sessions.

Methods
Twelve male well-trained rowers participated in a repeated measures design, performing three 2000 m rowing ergometer sessions interspersed by 3–7 days (S1, S2, S3). Surface electrodes were attached to the gastrocnemius, biceps femoris, gluteus maximus, erector spinae, vastus medialis, rectus abdominis and latissimus dorsi for EMG analysis.

Results
No differences existed between 2000 m sessions for EMG amplitude for any of the seven muscles (p = 0.146–0.979). Mean coefficient of variation of EMG for 6 of 7 muscles was ‘acceptable’ (12.3–18.6%), although classed as ‘weak’ for gastrocnemius (28.6%). Mean intra-class correlation coefficient values across muscles ranged from ‘moderate’ to ‘very large’ (0.31–0.89). Within-session EMG activation rates of vastus medialis were greater during 0–500 m and 1500–2000 m segments, compared with 500–1000 m and 1000–1500 m (p < 0.05). Values for biceps femoris and gluteus maximus were significantly higher during 1500–2000 m compared to 500–1000 m and 1000–1500 m (p < 0.05). The general pattern was for higher activation rates during 0–500 m and 1500–2000 m compared to 500–1000 m and 1000–1500 m. However, there were no between-sessions differences in EMG for any of the 500 m segments (p > 0.05).

Conclusion
Reliability of EMG values over repeated 2000 m sessions was generally ‘acceptable’. However, EMG was seemingly not sensitive enough to detect potential changes in neural activation between-sessions, with respect to changes in pacing strategy.
The association between sport nutrition knowledge, nutritional intake, energy availability, and training characteristics with the risk of an eating disorder amongst highly trained competitive road cyclists
Authors: Cook Oliver , Dobbin Nick 
Published: September 2022

Abstract
Purpose
To determine the association between sport nutrition knowledge, nutritional intake, energy availability, and training characteristics with the risk of an eating disorder amongst highly trained competitive cyclists.

Methods
Using an observational cohort study design, 36 male cyclists (age = 23.1 ± 3.9 years) provided information on personal characteristics, training history and functional threshold power. The cyclists completed the sports nutrition knowledge questionnaire (SNKQ) and brief eating disorder in athletes questionnaire (BEDA-Q) before submitting a three-day food diary to quantify energy and macronutrient intake, and calculate energy availability.

Results
The estimated lean body mass, years training, weekly on-bike training and functional threshold power were 57.6 ± 3.9 kg, 5.9 ± 3.0 years, 16.4 ± 3.2 h and 355 ± 33 W, respectively. The mean score for the SNKQ was 60.0 ± 8.4% whilst the BEDA-Q score was 4.3 ± 4.1 AU. Training and rest day energy availability was 16 ± 18 kcal·kg eLBM−1 and 44 ± 14 kcal·kg eLBM−1, respectively. Associations between SNKQ with energy intake (r = 0.13, P = 0.553) and availability (r = 0.21, P = 0.345) were trivial to small. There was a large, negative association between SNKQ and BEDA-Q (r = –0.55, P = 0.006) suggesting that for every correct answer on the SNKQ, the BEDA-Q score reduced by 0.3 AU. All other association with the BEDA-Q were trivial to small (r = –0.29–0.27, all P > 0.05).

Conclusion
The results indicate that sport nutrition knowledge and energy intake was insufficient to match their training demand on training days. The large, negative association between SNKQ and BEDA-Q suggests that those highly trained cyclists with less sport nutrition knowledge may be at a greater risk of an eating disorder.
Risk assessment and spatio-temporal distribution of dissolved trace metals in Swarna, Sharavati and Kali estuaries, South-West Coast of India
Authors: Nishitha D’Souza , Sudheer Athiyarath Krishnan , Arun Kumar , Amrish Vadakkeveedu Narayan , Mahesh Gaddam , Udayashankar Harikripa Narayana , Balakrishna Keshava 
Published: September 2022

Abstract
Trace metals act as a limiting nutrient and prerequisite for primary productivity in marine environments. The distribution of metals in dissolved phase along the salinity gradients of Swarna, Sharavati and Kali estuaries in southwestern India, during post and pre-monsoon seasons, were studied. We have investigated the behaviour of trace metals in the estuarine environment and their extent of impact on human health and ecosystem. The study revealed, non-conservative behaviour of dissolved Mn, Fe, Ni, Cd and Co in the estuaries. Whereas Cu behaved non-conservatively in post-monsoon and conservatively in pre-monsoon seasons. Risk assessment studies revealed that higher chronic daily intake (CDI) in humans, through dermal pathway, in Swarna and Sharavati estuaries during post-monsoon, whereas it was during pre-monsoon season in the Kali estuary. Hazard Index values for the studied metals in adults and children are below risk thresholds, though children are more prone to health risk through the dermal pathway.
Dwell Fatigue Behavior of Two-Phase Ti-6Al-4V Alloy at Moderate Temperature
Authors: Ziaja Waldemar , Kawalec Andrzej 
Published: September 2022

AbstractFatigue life of titanium and titanium alloys is frequently reduced if the load holds at the maximum stress are introduced, which is termed dwell debit. Many factors affect dwell fatigue of titanium alloys, like stress state, level and ratio, alloy chemistry, microstructure and microtexture, holding time and temperature. Dwell sensitivity of titanium alloys is usually attributed to the phenomenon of load shedding, which is a time-dependent redistribution of stress from so-called ‘weak’ to ‘strong’ grains possessing different crystallographic orientations. Stress concentration leads to crack initiation and formation of quasi-cleavage facets in ‘strong’ grains. Another factor contributing to dwell sensitivity of titanium alloys is time dependent strain accumulation, which is observed even at room temperature. In the paper, the effect of load holds and volume fraction of primary α phase on the fatigue behavior of Ti-6Al-4V alloy at the temperature of 150°C was investigated. Two variants of bi-modal microstructure of the alloy were obtained by means of the heat treatment. Stress controlled fatigue tests with and without hold time at maximum load and constant load creep test were carried out.
Backbone and side chain NMR assignment of the heme-nitric oxide/oxygen binding (H-NOX) domain from Nostoc punctiforme
Authors: Chasapi Styliani A. , Argyriou Aikaterini I. , Spyroulias Georgios A. 
Published: September 2022

AbstractSoluble guanylate cyclase (sGC) is considered as the primary NO receptor across several known eukaryotes. The main interest regarding the biological role and its function, focuses on the H-NOX domain of the β1 subunit. This domain in its active form bears a ferrous b type heme as prosthetic group, which facilitates the binding of NO and other diatomic gases. The key point that still needs to be answered is how the protein selectively binds the NO and how the redox state of heme and coordination determines H-NOX active state upon binding of diatomic gases. H-NOX domain is present in the genomes of both prokaryotes and eukaryotes, either as a stand-alone protein domain or as a partner of a larger polypeptide. The biological functions of these signaling modules for a wide range of genomes, diverge considerably along with their ligand binding properties. In this direction, we examine the prokaryotic H-NOX protein domain from Nostoc punctiforme (Npun H-NOX). Herein, we first report the almost complete NMR backbone and side-chain resonance assignment (1H, 13C, 15 N) of Npun H-NOX domain together with the NMR chemical shift-based prediction of the domain’s secondary structure elements.
Implantable defibrillator therapy and mortality in patients with non-ischaemic dilated cardiomyopathy
Authors: Theuns D. A. , Verstraelen T. E. , van der Lingen A. C. J. , Delnoy P. P. , Allaart C. P. , van Erven L. , Maass A. H. , Vernooy K. , Wilde A. A. M. , Boersma E. , Meeder J. G. 
Published: September 2022

Abstract
Background
Primary prophylactic implantable cardioverter-defibrillators (ICDs) in patients with non-ischaemic cardiomyopathy (NICMP) remains controversial. This study sought to assess the benefit of ICD therapy with or without cardiac resynchronisation therapy (CRT) in patients with NICMP. In addition, data were compared with real-world clinical data to perform a risk/benefit analysis.

Methods
Relevant randomised clinical trials (RCTs) published in meta-analyses since DANISH, and in PubMed, EMBASE and Cochrane databases from 2016 to 2020 were identified. The benefit of ICD therapy stratified by CRT use was assessed using random effects meta-analysis techniques.

Results
Six RCTs were included in the meta-analysis. Among patients without CRT, ICD use was associated with a 24% reduction in mortality (hazard ratio [HR]: 0.76; 95% confidence interval [CI]: 0.62–0.93; P = 0.008). In contrast, among patients with CRT, a CRT-defibrillator was not associated with reduced mortality (HR: 0.74, 95% CI 0.47–1.16; P = 0.19). For ICD therapy without CRT, absolute risk reduction at 3‑years follow-up was 3.7% yielding a number needed to treat of 27.

Conclusion
ICD use significantly improved survival among patients with NICMP who are not eligible for CRT. Considering CRT, the addition of defibrillator therapy was not significantly associated with mortality benefit compared with CRT pacemaker.
Preparation and Antibacterial Properties of Carvacrol-loaded Composite Microcapsules via Palygorskite-Stabilized Pickering Emulsions
Authors: Hui Aiping , Zhu Yongfeng , Yang Fangfang , Kang Yuru , Wang Aiqin 
Published: September 2022

AbstractEssential oils (including carvacrol, CAR) have been used in the medicinal and health field because of their broad-spectrum antibacterial activities. However, the volatility and pungent odor are still the greatest obstacles to wider application. The purpose of the present study was to address those problems by encapsulating the antibacterial CAR in palygorskite (Plg) by integrating it into Pickering emulsions with complex coacervation. The CAR in Pickering emulsion was formed firstly by stabilization with the CAR-modified Plg; then, the emulsion droplets were embedded and fixed in the microcapsule through the subsequent complex coacervation process, which occurred between the quaternary ammonium salt of chitooligosaccharides (HACC) and sodium alginate (SA) via calcium ions. The microcapsules obtained were characterized by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The results demonstrated that the microcapsules presented a nearly sphere-like shape with a mean diameter of 3.5 mm but had a porous interior structure. The Plg plays multiple roles in the preparation process, including increasing the emulsion stability, improving the encapsulation efficiency of CAR, and the thermostability of microcapsules. The microcapsules showed remarkable antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), and inhibition rates toward E. coli and S. aureus reached 100% when the microcapsules were encapsulated with 15 or 20% of CAR, respectively. The microcapsules obtained could be used as antibacterial agents in food preservatives, animal feed, and other health-related consumer products.