bluuebunny/crossref_metadata_2025_split huggingface dataset:
Institutional coordination arrangements as elements of policy design spaces: insights from climate policy
Authors: von Lüpke Heiner , Leopold Lucas , Tosun Jale 
Published: November 2022

AbstractThis study offers insights into the institutional arrangements established to coordinate policies aiming at the mitigation of and adaptation to climate change. Drawing on the literature on policy design, we highlight institutional arrangements as elements of policy design spaces and contend that they fall into four categories that either stress the political or problem orientation of this activity: optimal, technical, political, and sub-optimal. We use original data on 44 major economies and greenhouse gas-emitting countries to test this expectation. These data capture various properties of national coordination arrangements, including the types of coordination instruments in place, the degree of hierarchy, the lead government agency responsible for coordination, and the scope of cross-sectoral policy coordination. The dataset also captures the degree to which non-state actors are involved in coordination and whether coordination processes are supported by scientific knowledge. Using cluster analysis, we show that the institutional arrangements for the horizontal coordination of climate policy do indeed fall into the four above-mentioned categories. The cluster analysis further reveals that a fifth, hybrid category exists. Interestingly, the political orientation dominates in the institutional arrangements for the horizontal coordination of climate change mitigation, whereas the problem orientation is more important in the arrangements for the horizontal coordination of climate change adaptation.
Effect of replacing soybean meal (Glycine max) with sesame meal (Sesamum indicum) on productive traits, carcass characteristics, and gross profit margin in fattening lamb’s diets
Authors: Pérez-Trejo Eleazar , Andrade-Montemayor Héctor M. , Robles-Jimenez Lizbeth E. , Humarán María Concepción Méndez Gómez , Orozco-Estrada Elba , Hernández-Hernandez Jesús , Vargas-Bello-Pérez Einar , Gonzalez-Ronquillo Manuel 
Published: November 2022

AbstractThe objective of this study was to determine the effect of replacing soybean meal (Glycine max) with sesame meal (Sesamum indicum) on productive traits, carcass characteristics, and gross profit margin (GMP) in fattening lamb’s diets. For this, 42 Katahdin lambs were divided into three treatments in duplicate: basal diet + soybean meal (100S), basal diet + sesame meal/soybean meal (50/50SA), and basal diet + sesame meal (100A). Dry matter intake, daily weight gain (DWG), total kg gained (KgT), feed conversion (FC), and feed efficiency (FE) were evaluated; upon reaching the weight for sale, the animals were slaughtered, and hot carcass weight (HCW) was evaluated. The results were analyzed with a completely randomized design with repeated measures. Regarding time, no differences were found between treatments, for DWG (0.171 ± 0.006 kg/d), FC (6.7 ± 0.55), FE (0.175 ± 0.02), KgT (2.86 ± 0.13 kg), HCW (50.97 ± 0.79 kg), as well as for chest depth (26.96 ± 0.33 cm), leg width (20.63 ± 0.028 cm), leg diameter (60.7 ± 0.44 cm), and ribs width (24.05 ± 0.14 cm). GPM was 16.50%, 18.63%, and 19.97% for 100S, 50/50SA, and 100A, respectively. Overall, in fatting lamb diets, replacing soybean meal with sesame meal by either 50% or 100% substitution could be a feasible feeding strategy as in both cases, gross profit was increased, and no negative effects were found for productive traits and carcass quality.
Negotiating State-Civil Society Relations in Turkey: The Case of Refugee-Supporting Organizations
Authors: Kayali Nihal 
Published: November 2022

AbstractHow do nonstate organizations carry out their programs in political contexts hostile to civil society activity? This paper examines the case of refugee-supporting organizations in Turkey, which hosts over 3.6 million Syrians under a temporary protection regime. While the Turkish state has taken a central role in refugee reception, nonstate organizations have played a sizeable role in refugee support. Analyzing interviews with key personnel across 23 organizations in Istanbul, the paper finds that organizational capacity and organizational identity together explain variations in CSO-state relations. While high-capacity organizations that adopt a variety of “rights-based” and “needs-based” identities will cooperate with state institutions, lower-capacity organizations use comparable signifiers to justify selective engagement or avoidance of state institutions. The paper argues that analyzing how organizations negotiate their identities can help explain variations in CSO-state relations in restrictive contexts without relying on a priori assumptions about CSO alignment with or opposition to the state.
Shame and Blame in Gambling: Relationship with Emotion Regulation and Gambling Motives
Authors: Estévez Ana , Momeñe Janire , Jauregui Paula , Etxaburu Nerea 
Published: November 2022

Abstract
Gambling disorder is a problem that is affecting increasingly more people. It is associated with difficulties in emotion regulation, gambling motives, blame, and shame. This study aims to study the relationship between gambling severity, blame, and shame, independently and together with emotion regulation and gambling motives; to analyse the mediating role of emotion regulation in the relationship between gambling severity and shame; and to compare mean differences in the study variables according to the sample group. For this purpose, a clinical and non-clinical sample of 158 individuals (119 males and 39 females) ranging in age from 12 to 30 years (M = 19.70, SD = 5.35) was divided into three groups. The questionnaires were administered online and on paper. The results showed that blame and shame are related to the severity of gambling. In the case of shame, this relationship was found to be partially mediated by the emotion regulation strategy of self-blame. Gambling severity, blame and shame were also found to be related to various gambling motives and different emotion regulation strategies. All this information can be of great use in the prevention and treatment of gambling problems.
Two new root endophyte and nematode cyst parasite species of the widely distributed genus Laburnicola
Authors: Knapp Dániel G. , Akhmetova Galiya K. , Kovács Gábor M. , Dababat Abdelfattah A. , Maier Wolfgang , Ashrafi Samad 
Published: November 2022

AbstractFungal root endophytes, including the common form group of dark septate endophytes (DSEs), represent different taxonomic groups with potentially diverse life strategies. During surveys of DSE communities and of nematode cysts colonizing fungi, isolates representing Laburnicola (Didymosphaeriaceae, Pleosporales) lineages were discovered. Here we carried out a comprehensive study of the phylogenetic relationships and taxonomy of fungi collected from plant roots in Hungary, Mongolia, and Kazakhstan and from eggs of the cereal cyst nematode Heterodera filipjevi in Turkey. In addition to the study of the morphology and culture characteristics of the strains, four loci (internal transcribed spacer, partial large and small subunit regions of nuclear ribosomal DNA and partial translation elongation factor 1-alpha) were used to infer the molecular phylogenetic relationships of the strains within Laburnicola. The isolates were found to represent two distinct lineages, which are described here as novel species, Laburnicola nematophila and L. radiciphila. The interaction of the strains with plants and nematodes was examined using in vitro bioassays, which revealed endophytic interactions with the plant roots and parasitic interactions with the nematode eggs. Analyses of similar ITS sequences found in public databases revealed that members of the genus Laburnicola are widely distributed characteristic members of the plant microbiome, and they are reported as parasites of plant parasitic cyst nematodes here for the first time.
Application of 123I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography
Authors: Nakajo Masatoyo , Horizoe Yoshihisa , Kawaji Kodai , Jinguji Megumi , Tani Atsushi , Fukukura Yoshihiko , Ohishi Mitsuru , Yoshiura Takashi 
Published: November 2022

Abstract
Purpose
This study examined the usefulness of the maximum standardized uptake value (SUVmax) of myocardial [123I]-metaiodobenzylguanidine ([123I]-MIBG) to characterize myocardial function by comparing it with echocardiographic parameters in patients with pheochromocytoma.

Materials and methods
This study included 18 patients with pheochromocytoma who underwent both planar and [123I]-MIBG single-photon emission computed tomography/computed tomography scans and echocardiography before surgery. Myocardial [123I]-MIBG visibility and SUVmax were compared with echocardiographic parameters related to systolic and diastolic functions. The Mann–Whitney U test, Fisher exact test, or Spearman rank correlation assessed differences or relationships between two quantitative variables.

Results
On visual analysis, 6 patients showed normal myocardial [123I]-MIBG uptake, whereas 12 patients showed decreased myocardial [123I]-MIBG uptake. No patients showed systolic dysfunction. A significant difference was observed in the incidence of diastolic dysfunction between the groups with normal and decreased uptake (p = 0.009), and left ventricular (LV) diastolic dysfunction was observed in 9 (75%) of 12 patients with decreased myocardial uptake. The myocardial SUVmax was significantly lower in 9 patients with LV diastolic dysfunction than in 9 patients with normal cardiac function (1.67 ± 0.37 vs. 3.03 ± 1.38, p = 0.047). Myocardial SUVmax was positively correlated with septal e′ (early diastolic velocity of septal mitral annulus) (ρ = 0.51, p = 0.031) and negatively correlated with the septal E/e′ ratio (early mitral E-velocity to early diastolic velocity of septal mitral annulus; ρ =  − 0.64, p = 0.004), respectively.

Conclusions
LV diastolic dysfunction was inversely related to myocardial [123I]-MIBG uptake. Myocardial [123I]-MIBG SUVmax may be useful for characterizing cardiac function in patients with pheochromocytoma.
Second abstract.
The semiquantitative analysis using the myocardial SUVmax in 123I-MIBG SPECT/CT was found to be potentially useful for characterizing cardiac function in patients with pheochromocytoma.
Assessment of Exocrine Pancreatic Function Following Bariatric/Metabolic Surgery: a Prospective Cohort Study
Authors: Çiçek Okuyan Gülten , Akkuş Doğukan 
Published: November 2022

Abstract

Background
Exocrine pancreatic insufficiency (EPI) can be seen after bariatric/metabolic surgery. Fecal elastase level is a simple test in diagnosing and grading EPI. Quality of life changes in patients with bariatric/metabolic surgery related to gastrointestinal complaints is debated.

Aim
This study aimed to investigate rates and grades of EPI via fecal elastase levels and association between EPI and quality of life in bariatric surgery patients.

Methods
A prospective study was performed for patients with bariatric/metabolic surgery at their second-year follow-up. Fecal elastase levels were used to diagnose and grade EPI as severe or moderate. Patient’s gastrointestinal quality of life index (GIQLI) was calculated. Patients were grouped as sleeve gastrectomy (SG), one-anastomosis gastric bypass (OAGB), single-anastomosis sleeve ileal bypass (SASI), and transit bipartition (TB). Rates of severe or moderate EPI were primary outcome. Secondary outcome was an association between fecal elastase and GIQLI.

Results
There were 17, 29, 21, and 15 patients in OAGB, SG, TB, and SASI groups. There was no significant difference between groups in GIQLI scores and fecal elastase levels (p = 0.152 and p = 0.361). Rates of patients with moderate EPI in the groups OAGB, SG, TB, and SASI were 23.5%, 17.2%, 14.3%, and 20.0%. GIQLI scores were not significantly correlated with age, postoperative morphometric data, and fecal elastase values (p > 0.05).

Conclusion
Rates of patients with moderate EPI ranged from 14.3 to 23.5% at second-year follow-up. There was no patient with severe EPI. GIQLI scores were not significantly correlated with fecal elastase levels and different types of bariatric/metabolic surgery.

Graphical Abstract
A Push–Pull Mechanism Between PRRT2 and β4-subunit Differentially Regulates Membrane Exposure and Biophysical Properties of NaV1.2 Sodium Channels
Authors: Valente Pierluigi , Marte Antonella , Franchi Francesca , Sterlini Bruno , Casagrande Silvia , Corradi Anna , Baldelli Pietro , Benfenati Fabio 
Published: November 2022

AbstractProline-rich transmembrane protein 2 (PRRT2) is a neuron-specific protein implicated in the control of neurotransmitter release and neural network stability. Accordingly, PRRT2 loss-of-function mutations associate with pleiotropic paroxysmal neurological disorders, including paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine. PRRT2 is a negative modulator of the membrane exposure and biophysical properties of Na+ channels NaV1.2/NaV1.6 predominantly expressed in brain glutamatergic neurons. NaV channels form complexes with β-subunits that facilitate the membrane targeting and the activation of the α-subunits. The opposite effects of PRRT2 and β-subunits on NaV channels raises the question of whether PRRT2 and β-subunits interact or compete for common binding sites on the α-subunit, generating Na+ channel complexes with distinct functional properties. Using a heterologous expression system, we have observed that β-subunits and PRRT2 do not interact with each other and act as independent non-competitive modulators of NaV1.2 channel trafficking and biophysical properties. PRRT2 antagonizes the β4-induced increase in expression and functional activation of the transient and persistent NaV1.2 currents, without affecting resurgent current. The data indicate that β4-subunit and PRRT2 form a push–pull system that finely tunes the membrane expression and function of NaV channels and the intrinsic neuronal excitability.
Efficacy and safety of equine anti-thymocyte immunoglobulin (eATG) in three Japanese patients with moderate to very severe aplastic anemia: a case series
Authors: Kanda Yoshinobu , Mori Takehiko , Narita Atsushi , Wolter Kevin D. , Yoshimatsu Hiroki , Nishimura Kazuma 
Published: November 2022

AbstractAplastic anemia results from lymphocyte-mediated destruction of hematopoietic stem cells. Immunosuppressive therapy with anti-thymocyte globulin (ATG) and cyclosporine is the standard front-line treatment for patients with severe aplastic anemia who are not suitable candidates for stem cell transplants. PF-06462700 is a potent equine ATG that targets T-lymphocytes and has been approved as a treatment for aplastic anemia outside of Japan for over 30 years. Due to the high medical need for PF-06462700, the Ministry of Health, Labor and Welfare requested its development for Japanese patients with aplastic anemia. In this case series, the efficacy and safety of PF-06462700, administered intravenously at 40 mg/kg/day for 4 days, were assessed over a 24-week period. This was as an open-label, single-arm, multicenter clinical study designed to enroll a minimum of three Japanese participants with aplastic anemia. Two participants met the primary outcome of hematologic response at week 12 and improvements in disease severity were observed. No deaths or serious adverse events were reported. The efficacy results from this case series suggest that administration of PF-06462700 is generally well-tolerated and produces a hematologic response in Japanese patients with aplastic anemia, which should be further evaluated in real-world studies.ClinicalTrials.gov identifier: NCT04350606.
The Effect of Extracellular Vesicles on Thrombosis
Authors: He Youfu , Wu Qiang 
Published: November 2022

Abstract
The risk of cardiovascular events caused by acute thrombosis is high, including acute myocardial infarction, acute stroke, acute pulmonary embolism, and deep vein thrombosis. In this review, we summarize the roles of extracellular vesicles of different cellular origins in various cardiovascular events associated with acute thrombosis, as described in the current literature, to facilitate the future development of a precise therapy for thrombosis caused by such vesicles. We hope that our review will indicate a new horizon in the field of cardiovascular research with regard to the treatment of acute thrombosis, especially targeting thrombosis caused by extracellular vesicles secreted by individual cells. As more emerging technologies are being developed, new diagnostic and therapeutic strategies related to EVs are expected to be identified for related diseases in the future.
Amphilagus plicadentis (Lagomorpha, Mammalia) from the Tagay locality (Olkhon Island, Baikal region, Eastern Siberia)
Authors: Erbajeva Margarita A. , Daxner-Höck Gudrun , Mörs Thomas 
Published: November 2022

AbstractNew excavations in the Tagay locality have revealed the presence of Amphilagus plicadentis Erbajeva, 2013, which belongs to the palaeolagine Lagomorpha rather than leporids, previously referred to Procaprolagus sp. (Logachev et al., 1964). Herein, we report a comprehensive morphological description of this species and compare it with the other known species of the genus Amphilagus. The Tagay lagomorph is conspecific with the Early Miocene species Amphilagus plicadentis found at locality Unkheltseg (UNCH-A) (biozone D; Early Miocene) in the Valley of Lakes, Central Mongolia. The Tagay specimens suggest a more advanced evolutionary stage of A. plicadentis and an age around Early/Middle Miocene transition.
Computer simulation of molecular recognition in biomolecular system: from in silico screening to generalized ensembles
Authors: Fukunishi Yoshifumi , Higo Junichi , Kasahara Kota 
Published: November 2022

AbstractPrediction of ligand-receptor complex structure is important in both the basic science and the industry such as drug discovery. We report various computation molecular docking methods: fundamental in silico (virtual) screening, ensemble docking, enhanced sampling (generalized ensemble) methods, and other methods to improve the accuracy of the complex structure. We explain not only the merits of these methods but also their limits of application and discuss some interaction terms which are not considered in the in silico methods. In silico screening and ensemble docking are useful when one focuses on obtaining the native complex structure (the most thermodynamically stable complex). Generalized ensemble method provides a free-energy landscape, which shows the distribution of the most stable complex structure and semi-stable ones in a conformational space. Also, barriers separating those stable structures are identified. A researcher should select one of the methods according to the research aim and depending on complexity of the molecular system to be studied.
How intercultural experience affects university students’ gender views: potential for transforming higher education in Japan
Authors: Uematsu‑Ervasti Kiyoko , Kawachi Kumiko 
Published: November 2022

AbstractReducing gender disparities in Japan is an urgent issue that requires the attention of multilevel stakeholders, including higher education institutions. Under Sustainable Development Goal 4, target 4.7 calls for educational institutions, including universities, to explore innovative approaches to tackle issues such as gender inequality. The transition from student life to adulthood is a crucial time for university students as they face and become aware of gender inequalities in society. This study examines various opportunities in higher education, such as short study-abroad programs and globalization-related coursework, that positively influence university students’ understanding of others and potentially broaden their gender perspectives. Historically, the impacts of studying abroad and intercultural experiences have only been subjectively assessed based on participants’ self-evaluation. However, by using the Beliefs, Events, and Values Inventory, quantified data can be used to evaluate the nature and form of depth-based growth and compare three cases for potential changes before, after, or during educational programs. The study’s findings shed light on opportunities and barriers to transforming students’ views especially on gender issues. The study reveals (1) signs of improvement in students’ gender perspectives after participating in a short study-abroad program, (2) that international students with diverse experiences tend to demonstrate lower gender traditionalism, and (3) that freshmen and sophomores have relatively moderate views on gender norms, indicating that further intervention could improve their gender perspectives. The results showcase the possibility of developing meaningful study-abroad programs and other coursework to drive the positive change in students’ perspectives, especially regarding gender.
The radical inclusive curriculum: contributions toward a theory of complete education
Authors: de la Herrán Gascón Agustín , Herrero Pablo Rodríguez 
Published: November 2022

AbstractThis paper contributes to curriculum theory from the perspective of a fundamental critique of education. Its objective is two-fold: to analyze both traditional and critical approaches to the curriculum and the types of education that flow from them and to propose changes that could result in significant improvements to the curricula through the radical and inclusive approach. The principles of pedagogy are redefined from the standpoint of this approach, aiming to enhance the educational potential of the curricula. The method of the paper is hermeneutic and dialectical, critically disputing the utility of curriculum theory and of the international policies that drive current educational practice. The essay’s arguments are developed throughout in the dialogical space between the critique and the proposed changes. These arguments are oriented toward complementarity and aim to redefine education and the curriculum in terms of complexity and a higher level of consciousness. The conclusions suggest that the radical and inclusive approach can produce significant, thoroughgoing change in curricula, education, and pedagogy.
Coherent causal control: a new distinction within causation
Authors: Weber Marcel 
Published: November 2022

AbstractThe recent literature on causation has seen the introduction of several distinctions within causation, which are thought to be important for understanding the widespread scientific practice of focusing causal explanations on a subset of the factors that are causally relevant for a phenomenon. Concepts used to draw such distinctions include, among others, stability, specificity, proportionality, or actual-difference making. In this contribution, I propose a new distinction that picks out an explanatorily salient class of causes in biological systems. Some select causes in complex biological systems, I argue, have the property of enabling coherent causal control of these systems. Examples of such control variables include hormones and other signaling molecules, e.g., TOR (target of rapamycin), morphogens or the products of homeotic selector genes in embryonic pattern formation. I propose an analysis of this notion based on concepts borrowed from causal graph theory.