bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intereye structure–function relationship using photopic negative response in patients with glaucoma or glaucoma suspect
Authors: Lee Jihye , Kim Seong Ah , Lee Jiyun , Park Chan Kee , Jung Kyoung In 
Published: August 2022

AbstractWe evaluated the intereye structure–function relationship in glaucoma patients using photopic negative response in electroretinogram analysis. Patients with confirmed glaucoma (36 eyes, 36 patients) or suspected glaucoma (19 eyes, 19 patients) were included in this study. Electroretinogram (RETI-scan) was performed with red stimulus on blue background. Intereye comparison for 55 patients was performed between better eyes and worse eyes, which were divided based on average retinal nerve fiber layer (RNFL) thickness measured using spectral-domain optical coherence tomography. In the intereye analysis, PhNR amplitude was lower in worse eyes than in better eyes (P < 0.001). The intereye difference in PhNR amplitude was significantly correlated with intereye difference in average RNFL, as well as average or minimum ganglion cell-inner plexiform layer (GCIPL) thickness (P = 0.006, 0.044, 0.001). In patients with mean deviation ≥ − 6 dB of worse eyes, the intereye difference in PhNR amplitude was significantly associated with intereye difference in average RNFL thickness or minimum GCIPL thickness (P = 0.037, 0.007), but significant correlation was not found between mean sensitivity of visual field tests and structural parameters. In conclusion, PhNR performed well with regard to intereye structure–function association in glaucoma patients, especially at the early stage.
Application of immune enhanced organoids in modeling personalized Merkel cell carcinoma research
Authors: Forsythe Steven D. , Erali Richard A. , Laney Preston , Sivakumar Hemamylammal , Li Wencheng , Skardal Aleksander , Soker Shay , Votanopoulos Konstantinos I. 
Published: August 2022

AbstractMerkel cell carcinoma (MCC) is a rare neuroendocrine cutaneous cancer, with incidence of less than 1/100,000, low survival rates and variable response to chemotherapy or immunotherapy. Herein we explore the application of patient tumor organoids (PTOs) in modeling personalized research in this rare malignancy. Unsorted and non-expanded MCC tumor cells were isolated from surgical specimens and suspended in an ECM based hydrogel, along with patient matched blood and lymph node tissue to generate immune enhanced organoids (iPTOs). Organoids were treated with chemotherapy or immunotherapy agents and efficacy was determined by post-treatment viability. Nine specimens from seven patients were recruited from December 2018-January 2022. Establishment rate was 88.8% (8/9) for PTOs and 77.8% (7/9) for iPTOs. Histology on matched patient tissues and PTOs demonstrated expression of MCC markers. Chemotherapy response was exhibited in 4/6 (66.6%) specimens with cisplatin and doxorubicin as the most effective agents (4/6 PTO sets) while immunotherapy was not effective in tested iPTO sets. Four specimens from two patients demonstrated resistance to pembrolizumab, correlating with the corresponding patient’s treatment response. Routine establishment and immune enhancement of MCC PTOs is feasible directly from resected surgical specimens allowing for personalized research and exploration of treatment regimens in the preclinical setting.
A realistic morpho-anatomical connection strategy for modelling full-scale point-neuron microcircuits
Authors: Gandolfi Daniela , Mapelli Jonathan , Solinas Sergio , De Schepper Robin , Geminiani Alice , Casellato Claudia , D’Angelo Egidio , Migliore Michele 
Published: August 2022

AbstractThe modeling of extended microcircuits is emerging as an effective tool to simulate the neurophysiological correlates of brain activity and to investigate brain dysfunctions. However, for specific networks, a realistic modeling approach based on the combination of available physiological, morphological and anatomical data is still an open issue. One of the main problems in the generation of realistic networks lies in the strategy adopted to build network connectivity. Here we propose a method to implement a neuronal network at single cell resolution by using the geometrical probability volumes associated with pre- and postsynaptic neurites. This allows us to build a network with plausible connectivity properties without the explicit use of computationally intensive touch detection algorithms using full 3D neuron reconstructions. The method has been benchmarked for the mouse hippocampus CA1 area, and the results show that this approach is able to generate full-scale brain networks at single cell resolution that are in good agreement with experimental findings. This geometric reconstruction of axonal and dendritic occupancy, by effectively reflecting morphological and anatomical constraints, could be integrated into structured simulators generating entire circuits of different brain areas facilitating the simulation of different brain regions with realistic models.
One-particle engine with a porous piston
Authors: Álvarez Carlos E. , Camargo Manuel , Téllez Gabriel 
Published: August 2022

AbstractWe propose a variation of the classical Szilard engine that uses a porous piston. Such an engine requires neither information about the position of the particle, nor the removal and subsequent insertion of the piston when resetting the engine to continue doing work by lifting a mass against a gravitational field. Though the engine operates in contact with a single thermal reservoir, the reset mechanism acts as a second reservoir, dissipating energy when a mass that has been lifted by the engine is removed to initiate a new operation cycle.
Light color efficiency-balanced trans-palpebral illumination for widefield fundus photography of the retina and choroid
Authors: Son Taeyoon , Ma Jiechao , Toslak Devrim , Rossi Alfa , Kim Hoonsup , Chan R. V. Paul , Yao Xincheng 
Published: August 2022

AbstractA wide-field fundus camera, which can selectively evaluate the retina and choroid, is desirable for better detection and treatment evaluation of eye diseases. Trans-palpebral illumination has been demonstrated for wide-field fundus photography, but its application for true-color retinal imaging is challenging due to the light efficiency delivered through the eyelid and sclera is highly wavelength dependent. This study is to test the feasibility of true-color retinal imaging using efficiency-balanced visible light illumination, and to validate multiple spectral imaging (MSI) of the retina and choroid. 530 nm, 625 nm, 780 nm and 970 nm light emission diodes (LED)s are used to quantitatively evaluate the spectral efficiency of the trans-palpebral illumination. In comparison with 530 nm illumination, the 625 nm, 780 nm and 970 nm light efficiencies are 30.25, 523.05, and 1238.35 times higher. The light efficiency-balanced 530 nm and 625 nm illumination control can be used to produce true-color retinal image with contrast enhancement. The 780 nm light image enhances the visibility of choroidal vasculature, and the 970 nm image is predominated by large veins in the choroid. Without the need of pharmacological pupillary dilation, a 140° eye-angle field of view (FOV) is demonstrated in a snapshot fundus image. In coordination with a fixation target, the FOV can be readily expanded over the equator of the eye to visualize vortex ampullas.
Sustainable traditional grass cloth fiber dyeing using the Taguchi L16 (4^4) orthogonal design
Authors: Lin Lina , Jiang Tiancheng , Li Le , Pervez Md. Nahid , Zhang Cong , Yan Chao , Cai Yingjie , Naddeo Vincenzo 
Published: August 2022

AbstractFor many centuries, traditional grass cloth has been used as an important raw material for home textiles in China, but its market can be expanded by incorporating color. Reactive Red 2 (R2), Reactive Blue 194 (B194), and Reactive Orange 5 (O5) were used in this work to explore the dyeing behavior of sustainable traditional grass fiber using industrial dyeing methods. Initially, an L16 (4^4) orthogonal design was schematically applied to carry out the dyeing process and it was determined that the total dye fixation rate (T%) of B194 dye was the best among the three dyes. Accordingly, a statistical Taguchi technique was analyzed on a larger scale to optimize the dyeing process parameters (salt concentration, fixation time, fixation temperature, and solution pH) of B194, in which solution pH was found to be the most influential factor in achieving the highest T%. This phenomenon was also verified using analysis of variance (ANOVA), where the solution pH was found to be the biggest contributor (50%) and statistically significant (p < 0.05). Finally, confirmation tests were conducted under optimized conditions and a higher T% (53.18%) was determined compared to initial conditions (48.40%). Later, Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) were used to analyze the structural characteristics and found that grass cloth was chemically stable, yet gummy materials were still observed on their surface, which was also confirmed from digital photographs. Generally, the color coordinates and fastness properties were also satisfactory.
Smoking and microvascular free flap perfusion in head and neck reconstruction: radial free forearm flaps and anterolateral thigh flaps
Authors: Ooms Mark , Puladi Behrus , Houschyar Khosrow Siamak , Heitzer Marius , Rashad Ashkan , Bickenbach Johannes , Hölzle Frank , Modabber Ali 
Published: August 2022

AbstractHead and neck reconstruction with microvascular free flaps is frequently performed in smokers. Smoking causes various alterations in the cardiovascular system. The aim of this study was to investigate the effects of smoking on flap perfusion as a critical factor for flap survival. A total of 370 patients reconstructed with a radial free forearm flap (RFFF) or anterolateral thigh flap (ALTF) in the head and neck region between 2011 and 2020 were retrospectively analyzed. Flap perfusion measurements with the O2C tissue oxygen analysis system were compared between nonsmokers, light smokers (< 20 pack-years), and heavy smokers (≥ 20 pack-years). The blood flow was intraoperatively equal in RFFFs (84.5 AU vs. 84.5 AU; p = 0.900) and increased in ALTFs (80.5 AU vs. 56.5 AU; p = 0.001) and postoperatively increased in RFFFs (114.0 AU vs. 86.0 AU; p = 0.035) and similar in ALTFs (70.5 AU vs. 71.0 AU; p = 0.856) in heavy smokers compared to nonsmokers. The flap survival rate was similar in nonsmokers, light smokers, and heavy smokers (97.3%, 98.4%, and 100.0%). Smoking partially increases rather than decreases microvascular free flap perfusion, which may contribute to similar flap survival rates in smokers and nonsmokers.
Calpains in cyanobacteria and the origin of calpains
Authors: Vešelényiová Dominika , Hutárová Lenka , Lukáčová Alexandra , Schneiderová Mária , Vesteg Matej , Krajčovič Juraj 
Published: August 2022

AbstractCalpains are cysteine proteases involved in many cellular processes. They are an ancient and large superfamily of enzymes responsible for the cleavage and irreversible modification of a large variety of substrates. They have been intensively studied in humans and other mammals, but information about calpains in bacteria is scarce. Calpains have not been found among Archaea to date. In this study, we have investigated the presence of calpains in selected cyanobacterial species using in silico analyses. We show that calpains defined by possessing CysPC core domain are present in cyanobacterial generaAnabaena,Aphanizomenon,Calothrix,Chamaesiphon,Fischerella,Microcystis,ScytonemaandTrichormus. Based on in silico protein interaction analysis, we have predicted putative interaction partners for identified cyanobacterial calpains. The phylogenetic analysis including cyanobacterial, other bacterial and eukaryotic calpains divided bacterial and eukaryotic calpains into two separate monophyletic clusters. We propose two possible evolutionary scenarios to explain this tree topology: (1) the eukaryotic ancestor or an archaeal ancestor of eukaryotes obtained calpain gene from an unknown bacterial donor, or alternatively (2) calpain gene had been already present in the last common universal ancestor and subsequently lost by the ancestor of Archaea, but retained by the ancestor of Bacteria and by the ancestor of Eukarya. Both scenarios would require multiple independent losses of calpain genes in various bacteria and eukaryotes.
The Influence of Noise Type and Semantic Predictability on Word Recall in Older Listeners and Listeners With Hearing Impairment
Authors: Carter Brittney L. , Apoux Frédéric , Healy Eric W. 
Published: August 2022

Purpose:
A dual-task paradigm was implemented to investigate how noise type and sentence context may interact with age and hearing loss to impact word recall during speech recognition.

Method:
Three noise types with varying degrees of temporal/spectrotemporal modulation were used: speech-shaped noise, speech-modulated noise, and three-talker babble. Participant groups included younger listeners with normal hearing (NH), older listeners with near-normal hearing, and older listeners with sensorineural hearing loss. An adaptive measure was used to establish the signal-to-noise ratio approximating 70% sentence recognition for each participant in each noise type. A word-recall task was then implemented while matching speech-recognition performance across noise types and participant groups. Random-intercept linear mixed-effects models were used to determine the effects of and interactions between noise type, sentence context, and participant group on word recall.

Results:
The results suggest that noise type does not significantly impact word recall when word-recognition performance is controlled. When data from noise types were pooled and compared with quiet, and recall was assessed: older listeners with near-normal hearing performed well when either quiet backgrounds or high sentence context (or both) were present, but older listeners with hearing loss performed well only when both quiet backgrounds and high sentence context were present. Younger listeners with NH were robust to the detrimental effects of noise and low context.

Conclusions:
The general presence of noise has the potential to decrease word recall, but type of noise does not appear to significantly impact this observation when overall task difficulty is controlled. The presence of noise as well as deficits related to age and/or hearing loss appear to limit the availability of cognitive processing resources available for working memory during conversation in difficult listening environments. The conversation environments that impact these resources appear to differ depending on age and/or hearing status.
Robust private information retrieval for low encoding/decoding complexity distributed storage
Authors: Dai Mingjun , Deng Haiyan , Li Xiaofeng , Su Gongchao , Zhang Zhonghao 
Published: August 2022

AbstractPrivate information retrieval (PIR) means a user retrieves a file while revealing no information on which file is being retrieved. In classic PIR, the user needs to wait for the responses of all the storage nodes. However, in general, there may be some nodes that are unresponsive, in which case it is formulated as v‐robust PIR in the network coding (NC) structured distributed storage system (DSS), where v denotes the number of unresponsive nodes. We consider PIR with unresponsive nodes under the framework of NC structured DSS. In particular, the storage nodes adopt combination property with zigzag decodable (CP‐ZD) storage code since it has the advantage of extremely low decoding complexity, which is promised by zigzag decoding (ZD) within a binary field. We design a v‐robust PIR scheme with its download communication cost slightly larger than existing studies, but its decoding complexity is significantly reduced when compared with existing studies.
Breakdown behavior of SiC photoconductive switch with transparent electrode
Authors: Wang Bin , Wang Langning , Niu Xinyue , Chu Xu , Yi Muyu , Yao Jinmei , Xun Tao 
Published: August 2022

The breakdown behavior of a V-doped 4H silicon carbide photoconductive switch with a transparent electrode under a high electric field is studied. The device is triggered by a laser pulse below the bandgap wavelength with a repetition rate of 100 Hz. The light peak-power of the laser pulse reaches hundreds of kW, and the bias voltage is increased from 10 to 20 kV. With the accumulation of the number of pulses, the device shows breakdown behavior. Through the microscopic diagnosis of damaged and breakdown devices, according to the analysis of theoretical and simulation results, the breakdown of the device is due to the interaction between the laser and the aluminum doped zinc oxide transparent electrode on the device surface, resulting in the melting of the transparent electrode. The direct illuminate of the laser can form a field enhancement effect at the junction of the substrate and the transparent electrode, resulting in the damage of the device and the formation of pre-breakdown. Finally, the breakdown of the device inevitably occurs.
The visuality of metaphors*
Authors: Gal Michalle 
Published: August 2022

Abstract
This chapter proposes to define metaphor as a visual-material structure, the sphere of which is ontological rather than cognitive or conceptual. It argues that the essence of metaphor, as either an aesthetic or a communicative unit or both, resides in the qualitative dimension and appearance, or even materiality, of the metaphorical medium and its form. The chapter thus offers a new theory of metaphor, focusing on the medium of metaphor, which composes and transfigures or reconstructs its target anew: a composition that is prior to understanding or conceptualizing the target. In doing so, the chapter presents a formalist ontology of metaphors, established via an externalist account of metaphors, as opposed to the prevailing cognitivistconceptualist account which I characterize as internalist. The various kinds of metaphor – linguistic, poetic, visual or material – are based on their external structure, rather than an internal-conceptual mechanism of understanding, as assumed by a significant segment of the literature. Visual metaphor, therefore, is the paradigmatic kind of metaphor, the analysis of which can be generalized to other kinds of metaphor.
Furthermore, the chapter tries to overcome the current discrepancy between the formalist character of the metaphorical medium and the dominance of cognitivist and conceptualist theories of metaphor. Challenging these, I claim that if the identity of metaphor is indeed based on its composition, then it is actually based on its aesthetic qualities. That is to say, not only are there autonomous visual or material metaphors, that are not based on linguistic or conceptual ones, but linguistic and conceptual metaphors are based on visuality: they are enabled by the structural possibilities offered by visual media.
Doing We – Working alliance in psychotherapeutic relationships
Authors: Buchholz Michael B. 
Published: August 2022

Abstract
Larger chunks from psychotherapeutic cooperations are presented. Cooperation is studied in empirical
psychotherapeutic process research as “working alliance” of which conceptual conflicts are outlined.
I follow a proposal by Ginzburg and Poesio (2016) to micro-analyze
hesitation markers as conversational equivalents to embodied pointing gestures. Several stories by patients are told in order
to “point” to comparisons between the stories. The concept of “tacit comparisons” is, thus,
introduced. Then, a recursive model of common ground is proposed with reference to cognitive-linguistic theory of metaphor
(Cienki und Müller 2010; Lakoff 1987).
The conversation creates in describable steps new metaphors indicating important change.
Mineralogical Studies and Radioactivity on Stream Sediments Around Wadi Aidib Area, South Eastern Desert, Egypt
Authors: Hassan M , El Shafey M , M B Bayoumi , Ebyan O A 
Published: August 2022

Abstract
Wadi Aidib lie at southern part of the Eastern Desert of Egypt, between 22° 15’ - 22° 21’ N and Longitudes 36° 20’ - 36° 30’ E, covering an area of about 30km2. It is covered by basement rocks dissected by several wadies, Wadi Aidib as a main wadi with several tributaries. Constant of channel maintenance showed the dissection of the studied basin by lineaments, fractures and joints, dissection is minimized in wadi Aidib. Landsat ETM+ false color composite image (bands 3, 2, 1) The rock types wide spread out at Wadi Aidib area contains metavolcanics, alkali feldspar granites, quartz diorites, biotite granites metasediments. Heavy liquid separation and magnetic separation techniques in addition to microscopic examination for the studied stream sediment samples were applied. The mineral resource tonnage for each concerned economic mineral 171.315 ilmenite; 93.150, magnetite; 25.110, zircon; 9.720, total rutile; 7.695, garnet; 1.215, monazite and 810.000 green silicates, in thousands of tons. The studied stream sediments are measured radiometrically using gamma-ray spectrometer for determination the radionuclides contents. U concentration varies between 1 and 2 ppm with 1.69 as an average, Th from 3 to 7 ppm with an average 4.92 ppm.
Hybrid Hydro-pyrometallurgical Process for Zn Recovery from Electric Arc Furnace Dust
Authors: Bayoumi R.A. , Abdelmonem N. M. , Soliman M. A. , Ismail I.M. , Refaat A. A. 
Published: August 2022

Abstract
Electric arc furnace dust (EAFD) which is considered hazardous waste, contains significant amounts of Zinc (Zn), iron (Fe), and some dangerous elements. Zn exists in the dust as Zinc Oxide (ZnO) and Zinc Ferrite (ZnFe2O3) which is difficult to be leached with traditional methods. The main objective of the suggested process is to recover Zn from EAFD by using a hybrid pyro/hydrometallurgical method. This method includes mixing cement dust and EAFD and heating the mixture in a pyrometallurgical treatment step to convert ZnFe2O3 to ZnO. This step is followed by leaching the treated dust with sodium hydroxide (NaOH) solution using different Solid/Liquid (S/L) ratios through different time intervals in a hydrometallurgical treatment step. Finally, Zn-metal can be recovered from the leached solution in an electrochemical step (electro-winning). About 82 % of the Zn originally presented in the EAFD sample was successfully extracted by using a treatment mixture of 2:1 cement dust: EAFD at 1000 °C for 2 hrs., then leaching with 2M NaOH solution with an S/L ratio of 1/20 for 6 hrs. at a stirring rate of 250 rpm.
Facile Synthesis and Catalytic Activity Assessment of Copper Chromite Nanoparticles for Ammonium Perchlorate Decomposition
Authors: Ismael Shukri , Deif A , Maraden Ahmed , Elbasuney Sherif 
Published: August 2022

Abstract
The universal burning rate modifier used in composite solid propellants is copper chromite. The fabrication of copper chromite nanoparticles (CCNs) is highly appreciated; as superior performance could be accomplished. This research looks at how copper chromite nanoparticles can be made in a sustainable way using hydrothermal processing. Mono-dispersed particles with a medium particle size of 12 nm were seen in TEM micrographs. The XRD diffractogram revealed a crystalline structure. The co-precipitation approach was used to incorporate CCNs into ammonium perchlorate (AP). Differential scanning calorimetry (DSC) and thermal gravimetric analysis were used to analyze the activity of catalysis in CCNs on AP breakdown (TGA). The enthalpy of AP breakdown was enhanced from 742 J/g to 1391 J/g. CCNs caused the Peak of high-temperature decomposition shift toward lower temperatures, resulting in the overlapping of the two peaks into a single peak. At 244 °C, CCNs showed a decrease in AP endothermic phase transition. These characteristics could ensure high-burning-rate catalyzed decomposition processes.