bluuebunny/crossref_metadata_2025_split huggingface dataset:
Searching of Clinical Trials Made Easier in cBioPortal Using Patients' Genetic and Clinical Profiles
Authors: Unberath Philipp , Mahlmeister Lukas , Reimer Niklas , Busch Hauke , Boerries Melanie , Christoph Jan 
Published: March 2022

Abstract
Background Molecular tumor boards (MTBs) cope with the complexity of an increased usage of genome sequencing data in cancer treatment. As for most of these patients, guideline-based therapy options are exhausted, finding matching clinical trials is crucial. This search process is often performed manually and therefore time consuming and complex due to the heterogeneous and challenging dataset.
Objectives In this study, a prototype for a search tool was developed to demonstrate how cBioPortal as a clinical and genomic patient data source can be integrated with ClinicalTrials.gov, a database of clinical studies to simplify the search for trials based on genetic and clinical data of a patient. The design of this tool should rest on the specific needs of MTB participants and the architecture of the integration should be as lightweight as possible and should not require manual curation of trial data in advance with the goal of quickly and easily finding a matching study.
Methods Based on a requirements analysis, interviewing MTB experts, a prototype was developed. It was further refined using a user-centered development process with multiple feedback loops. Finally, the usability of the application was evaluated with user interviews including the thinking-aloud protocol and the system usability scale (SUS) questionnaire.
Results The integration of ClinicalTrials.gov in cBioPortal is achieved by a new tab in the patient view where the genomic profile for the search is prefilled and additional parameters can be adjusted. These parameters are then used to query the application programming interface (API) of ClinicalTrials.gov. The returned search results subsequently are ranked and presented to the user. The evaluation of the application resulted in an SUS score of 83.5.
Conclusion This work demonstrates the integration of cBioPortal with ClinicalTrials.gov to use clinical and genomic patient data to search for appropriate trials within an MTB.
Multipass Yb : KGW disk amplifier
Authors: Potemkin A.K. , Martyanov M.A. , Mironov S.Yu. 
Published: March 2022

Abstract
We have investigated a multipass Yb : KGW disk amplifier based on the White cell configuration and pumped by a laser diode with a fibre output. It is shown that the three-mirror layout of the cell is three times more efficient than the four-mirror one, since the size and position of the signal beam on the surface of the active element do not depend on the cell number of passes. For a three-mirror cell scheme, a small-signal gain G = 168 is obtained in experiments for a pump power of 360 W. The experimentally achieved gain of two such amplifiers arranged in series is 6 × 104, which exceeds G
2 approximately two-fold.
Absorption spectra and mechanical properties of C : F nanocoatings deposited from laser plasma onto leucosapphire surface
Authors: Sergeev P.B. , Kravchuk K.S. , Morozov N.V. 
Published: March 2022

Abstract
It is experimentally shown that during laser annealing of micron layers of fluorocarbon oil by high-power KrF laser radiation pulses, C : F nanocoatings with a thickness of up to ∼100 nm can be synthesised on a leucosapphire surface. The absorption spectra of these coatings, measured in the 0.19 – 6 μm range, virtually coincided with the absorption spectra of fluorographene in the quantum energy range of 5 ± 1 eV. The nanohardness and elasticity modulus of the C : F nanocoatings are found to be 7 and 250 GPa, respectively, which is close to the characteristics of fluorographene.
Mobile gentrifers and leavers: tourist dwelling as an agent of exclusion in Barcelona.
Authors: Mendoza Javier Macías , Russo Antonio Paolo 
Published: March 2022

Abstract

The rise in popularity of short-term rentals (STRs) has been widely noted to affect housing affordability, thus presenting itself as a driver of social exclusion in tourist cities. It is also suggested, but less documented, that rent infation is not the only factor that may be pushing autochthonous residents out of neighbourhoods experiencing intense 'airbnbization'. Dwelling in STRs unfolds in ways that could be challenging to many aspects of everyday life for a stable population, such as night rest, security, familiarity with neighbours, health, and access to basic services. Our research on such issues is carried out in Vila de Gràcia, a neighbourhood of Barcelona where traditional gentrifcation is enmeshed with the rising tourist profle of the area. In our feldwork we examined how residents perceive and cope with such pressures and investigated how (and to what extent) the material hindrances produced by temporary dwelling can trigger the decision to move out.
Airbnb guests' pro-environmental behaviour and community resilience: mitigating the negative impacts of Airbnb tourism.
Authors: Xie Jing-hua , Gjerald Olga 
Published: March 2022

Abstract

Despite the significant amount of literature on tourists' pro-environmental behaviour (PEB), there is no study to systematically investigate the PEB of Airbnb guests. Understanding Airbnb guests' PEB is important to improve the host communities' resilience and mitigate the negative impacts associated with Airbnb growth. This chapter examines the determinants to Airbnb guests' PEB focusing on guests' knowledge of and concern about the environment. A binary logit model was applied using the survey data collected from Norwegian university students. The results support the hypothesis that Airbnb guests' environmental knowledge and concern are important in influencing their PEB. The study further tested if Airbnb guests behave differently when they are in or close to their home and when they travel. The findings show that respondents' behaviour does not seem to differ significantly. The study results enhance understanding of the Airbnb's impact on host communities and highlight the need to design PEB strategies specifically targeting Airbnb guests for successful destination governance and improved community resilience.
Modeling of lead-bismuth gallate glass ultra-flatted normal dispersion photonic crystal fiber infiltrated with tetrachloroethylene for high coherence mid-infrared supercontinuum generation
Authors: Van Lanh Chu , Le Hieu Van , Nguyen Nguyen Dang , Minh Ngoc Vo Thi , Dinh Quang Ho , Hoang Van Thuy , Thi Thuy Nguyen , Van Bien Chu 
Published: March 2022

Abstract
We report a numerical study on mid-infrared (IR) supercontinuum (SC) generation in the regime of all normal dispersion using lead bismuth gallate glass photonic crystal fiber. This fiber allows the changing of dispersion from anomalous dispersion to ultra-flat normal dispersion in the wavelength range of over 930 nm by filling its cladding holes with C2Cl4. Using a 12.5 kW laser pulse at 2.8 µm as a pump source, we demonstrate that a broad and highly coherent SC generation spectrum is generated in the wavelength range of 1.2

μ

m

–3.4

μ

m

with the effects of vacuum noise. However, pulse-to-pulse relative intensity noise significantly decreases the coherence. These interesting optical properties make the proposed C2Cl4—infiltrated fiber highly promising for various applications in the mid-IR regime, particularly, spectroscopy, optical coherence tomography, and metrology.
The vibration harmonic response analysis of drillstring in compound drilling
Authors: Tian Long , Jiang Zhenxin , Dong Guangjian , Kedi Liya , Fu Jianhong 
Published: March 2022

Abstract
The harmonic response analysis model of drillstring is established to improve borehole quality. The harmonic response laws of drillstring is discussed. Harmonic response analysis is made intensively for longitudinal vibration, including non-failure case and failure case. Position of the maximum response displacement of drillstring and the maximum response stress at corresponding position are obtained through harmonic response analysis. Absorber control measure is simulated to lower vibration amplitude of drillstring. New suggestions are put forward from the view of controlling drillstring vibration by comparing and classifying features of vibration control measures comprehensively. In course of designing drilling parameter, it is required to avoid or reduce drillstring resonance under low-order inherent frequency as much as possible and adopt targeted comprehensive control measures timely. The research result is of much significance to improve wellbore quality.
A review on Chemical Looping Water Splitting (CLWS) as a potential alternative to Steam Methane Reforming (SMR) for hydrogen production
Authors: Waikar S , Jena D , Deshpande A 
Published: March 2022

Abstract
Hydrogen is the fuel of the future as it is a clean fuel and its utilization doesn’t emit greenhouse gases. It is used in various industries from petroleum, fertilizers to pharmaceuticals and even electronics. There are numerous established processes for hydrogen production each having its advantages and disadvantages. The current benchmark is Steam Methane Reforming (SMR). Despite giving a stable output, it releases harmful gases in the environment and has other challenges. Therefore, there was a need to find an inexpensive, efficient and environmentally friendly process with possible CO2 sequestration. CLWS, an alternative to SMR is a three step process where a transition metal oxide, preferably an iron-based oxide undergoes reduction, steam iron process and oxidation to produce hydrogen. This process has many advantages like the production of separate H2 and CO2 streams, no need to have additional units like acid gas removal and pressure swing adsorption. The only challenge is to perform process simulations such that we obtain maximum H2 yield with minimum carbon deposits which reduce the efficiency and purity of the hydrogen produced. CLWS has been studied in detail and optimum parameters for each of the underlying processes have been compiled along with suitable reactor design schemes, thermodynamics etc.
Simulation and optimization of hydrogen-based hybrid renewable energy systems: Software tools and applications
Authors: Li Yaze , Li Guodong , Li Jin , Bénard Pierre , Chahine Richard , Xiao Jinsheng 
Published: March 2022

Abstract
With continuous fossil energy consumption and global warming, renewable energy has become more popular. Therefore, more and more researchers have begun to study hydrogen-based hybrid renewable energy systems. This article mainly summarizes the commercial software tools and the simulation of hybrid renewable energy systems in recent years. Firstly, the commonly used softwares and research methods are reviewed so that other researchers can choose suitable tools and strategies to conduct their researches. Then TRNSYS software is used to perform a case study in Yichang, Hubei, China. The established model is simulated according to the one-year load of the community. The simulation results show that the total power generation of the system can meet the load demand most of the time but is insufficient in some peak periods. The system can further be optimized using optimization methods to fully meet the load.
Prospects of charge signal analyses in liquid xenon TPCs with proportional scintillation in the liquid phase
Authors: Kuger F. , Dierle J. , Fischer H. , Schumann M. , Toschi F. 
Published: March 2022

Abstract
As liquid xenon TPCs increase in target mass while pursuing the direct detection of WIMP dark matter, the technical challenges arising due to their size call for new solutions and open the discussion on alternative detector concepts. Proportional scintillation in liquid xenon allows for a single-phase design evading problems related to the liquid-gas interface and the precise gas gap required in a dual-phase TPC.
Aside from a different scintillation mechanism, the successful detection- and analysis scheme of state-of-the-art experiments is maintained in this approach.
We study the impact on charge signal analysis in a single-phase detector of DARWIN dimensions, where the fast timing of the proportional scintillation signal allows for the precise identification of the single electrons in the ionisation signal.
Such a discrete electron-counting approach can lead to a better signal resolution for low energies when compared to the classical dual-phase continuous method.
The absence of the liquid-gas interface can further benefit the S2-only energy resolution significantly. This can reduce the uncertainties from the scintillation and signal-detection process to a level significantly below the irreducible fluctuation in the primary ionisation. Exploiting the precise electron arrival time information can further allow for a powerful single vs. multiple site interaction discrimination with 93% rejection efficiency and 98% signal acceptance. This outperforms the design goal of the DARWIN observatory by a reduction factor of 4.2 in non-rejected multiple site neutron events.
Sensitivity of regional monsoons to idealised equatorial volcanic eruption of different sulfur emission strengths
Authors: D’Agostino Roberta , Timmreck Claudia 
Published: March 2022

Abstract
The impact of volcanic forcing on tropical precipitation is investigated in a new set of sensitivity experiments within the Max Planck Institute Grand Ensemble framework. Five ensembles are created, each containing 100 realizations for an idealized ‘Pinatubo-like’ equatorial volcanic eruption with emissions covering a range of 2.5-40 Tg sulfur (S). The ensembles provide an excellent database to disentangle the influence of volcanic forcing on monsoons and tropical hydroclimate over the wide spectrum of the climate’s internal variability. Monsoons are generally weaker for two years after volcanic eruption and their weakening is a function of emissions. However, only a stronger than Pinatubo-like eruption (

⩾

10 Tg S) leads to significant and substantial monsoon changes, and some regions (such as North and South Africa, South America and South Asia) are much more sensitive to this kind of forcing than the others. The decreased monsoon precipitation is strongly tied to the weakening of the regional tropical overturning. The reduced atmospheric net energy input and increased gross moist stability at the Hadley circulation updraft due to the equatorial volcanic eruption, require a slowdown of the circulation as a consequence of less moist static energy exported away from the intertropical convergence zone.
The Effect of Variations of Fly Ash Filling Materials on Porous Concrete Using Local Aggregates from South Borneo
Authors: Purnamasari E , Gazali A , Januar M B 
Published: March 2022

AbstractSouth Kalimantan has local aggregates that can be used as porous concrete making materials, which is one of the innovations in the infrastructure of environmentally friendly road pavement that serves to drain surface water into the ground. Porous concrete produces a lot of empty space as an air cavity that is 15%-25% of its total volume and also has a slump value that is close to zero. This study uses fly ash filler material as one of the efforts to reduce cement in porous concrete making materials. This research aims to find out the characteristics of the material, the composition of variations of porous concrete mixture, compressive strength and porosity of porous concrete. Testing uses the SNI method which consists of testing cement, fly ash, coarse aggregates and concrete. Concrete testing is done, namely the compressive strenght and porosity of concrete. Based on theresults of research characteristics of cement and fly ash materials have met the specifications of SNI and the results of rough aggregate testing have met the specifications. In porous concrete the fly ash variation of EM0% is obtained the compressive strength is 20.37 MPa and its porosity is 2.34%; in porous concrete the variation of fly ash EM15% obtained the compressive strength of 21.44 MPa and porosity 2.07%, and porous concrete variation fly ash EM30% obtained the compressive strength of 6.05 MPa and porosity by 6.80%. From the results of the analysis, it is found that there is an inverse relationship between compressive strength and porosity. More higher the porosity of the porous concrete, more lower the compressive strength. This happens because the void ratio affects the compressive strength of porous concrete, more greater the void value making higher the porosity value and causes the compressive strength to decrease.
Recycled Coarse Aggregate from Concrete Waste Using DMDA for Concrete
Authors: Canseco-Tuñacao H A R , Remoto K , Melendres K , Deguzman I M 
Published: March 2022

AbstractThis study investigates the effect of the replacement of recycled concrete as coarse aggregates using the Densified Mixture Design Algorithm Method (DMDA) in unconfined concrete behavior. DMDA was applied to produce concrete with the least void. Compressive strength, flexural strength and split tensile strength tests were conducted on 7-, 14-, 28- and 56-day old specimens. Compressive strength test results showed that specimens with 20, 30, and 40% RCA replacements at 56 days are relatively lower compared to the control and with 10% RCA replacement specimens. The compressive strengths of the specimens with RCA replacements decreased as the amount of RCA increased. However, the 10% replacement specimens showed promising performance with an average strength of 3275 psi at 56 days with an 11.2% difference in compressive strength with the control with 0% replacement. A significant increase in compressive strengths between the 28- and 56-day specimens for all specimens was observed and accounted due to the pozzolanic activity of the type C fly ash used as filler. For flexural and splitting tensile strength, results showed that specimens with 40% replacement showed best performance with a 9.87% difference and roughly 1% greater with the control in terms of its flexural and splitting tensile strength, respectively.
Flood Mitigation in Banjar Regency, South Kalimantan, Indonesia in 2021: Between Hydro-meteorological factor and Anthropogenic factor
Authors: Novitasari Novitasari , Kurdi Holdani 
Published: March 2022

Abstract
The year 2021 in Banjar Regency and several other regencies in South Kalimantan Province opened with floods disaster. High rainfall caused the river to overflow; one of the rivers that overflowed was the Martapura River in Banjar Regency. The flood in 2021 is not the first flood disaster to occur, but a floods disaster that has occurred frequently. This flood is a fairly large flood compared to the previous flood. The areas affected by the large flood in Banjar Regency are in the Districts of Sungai Tabuk, Martapura Kota, East Martapura, West Martapura, Astambul, Karang Intan, and Pengaron. The method used in this research is to analyze the hydro-meteorological using the rainfall-runoff model, and the anthropogenic factors in the flood events in Banjar Regency be approached by the value of the C coefficient. The hydro-meteorological factors as natural factors cannot be predicted. The extreme rainfall on January 14, 2021 as 255.3 mm is higher than 100-years return period as 244.716 mm. Its caused biggest flood disaster in January 2021. The anthropogenic factors caused by humans can be reduced. One of the anthropogenic factors that have the most impact on any flood event is land-use change. Land-use change causes rainwater that falls cannot infiltrate into the ground. One of the most common community activities is to close the yard and the drains so that rainwater does not have access to penetrate the ground. Second, the conversion of agricultural land, and swampland into residential and industrial areas. The third factor that is no less important is the role of the community in development that is not environmentally friendly, one of them by dredging for houses or other buildings. These three anthropogenic factors cause the C value to increase, and it increases the flood discharge.
Assessment of groundwater quality in Randublatung Groundwater Basin
Authors: Hartono A , Hendrayana H , Akmaluddin  
Published: March 2022

Abstract
Groundwater is used for domestic and industrial water supply and irrigation. Land use in the Randublatung groundwater basin is mainly agricultural, using groundwater as the primary source. The present study aims to assess the groundwater quality in Randublatung groundwater basin. Groundwater quality in the study area, 13 groundwater samples were collected and analyzed for various parameters. Physicochemical parameters of groundwater such as Electrical conductivity (EC), total dissolved solids (TDS), pH, Chloride (Cl), Calcium (Ca), Magnesium (Mg), Sodium (Na), Potassium (K), Sulfate (SO4), Bicarbonate (HCO3), Nitrate (NO3) were determined. A chemical index like percentage of sodium, sodium adsorption ratio (SAR), permeability index (PI), Kelly Index, and Magnesium ratio can be used to determine groundwater quality for irrigation. From the study, 3 of 13 samples are suitable for drinking. Based on Wilcox classification, 23% of the groundwater samples are suitable for irrigation. From the USSL chart, there are four types of water quality. All groundwater samples are in a low sodium hazard condition based on the sodium absorption ratio. The permeability index and magnesium ratio indicate that all groundwater samples are of good quality for irrigation utility. Based on the Kelly index, there is one sample unsuitable for irrigation.
Garlic essential oil as an edible film antibacterial agent derived from Nagara sweet potato starch applied for packaging of Indonesian Traditional Food - Dodol
Authors: Sihombing N , Elma M , Thala’ah R N , Simatupang F A , Pradana E A , Rahma A 
Published: March 2022

Abstract
Edible film as food packaging is an alternative solution to maintain Dodol quality and prevent to decay during storage. Commonly, edible films were prepared from starch-based materials. Nevertheless, the edible film which only made from starch has a limitation due does not provided antibacterial properties. Therefore, this study aims to synthesis and characterize of edible film from Nagara sweet potato with addition of garlic essential oil which applicated for Kandangan Dodol packaging. Synthesis of edible film was carried by prepared starch derived Nagara sweet potato by extraction. Garlic essential oil was added with various concentrations (0%, 0.25%, 0.5%, 0.75% v/v total). Furthermore, the edible film was characterized to determine the effect of the concentration of garlic essential oil extract on thickness, water absorption, air solubility, and mechanical properties of the edible film, as well as the application of edible film on Kandangan Dodol to determine the stored life time. Edible film with the addition of 0.75% garlic essential oil has a thickness of 0.1 mm with resistance and solubility to water of 50.53% and 39.46%., respectively. The presence of garlic essential oil in edible film has an important role to maintain the quality of Kandangan Dodol on antibacterial activity.
Investigation of enhancing industrial waste as a soft soil stabilizer
Authors: Yuniati Pratiwi Ade , Prasetia Irfan , Yahya M. , Effendi Rustam 
Published: March 2022

Abstract
This study compares two methods in enhancing fly ash as a soft-soil stabilizer. The first is using fly ash with mixing proportion varies from 10%, 15%, and 20%. In the second method, 10% cement combines with fly ash mixing proportion in the first method. Based on CBR test results, the fly-ash effectively increases the soft soil capacity with a CBR maximum of 9.31% at 20% fly ash in the first method. The second method enhances more impact than the first method with a CBR maximum of 49.36% at 20% fly ash. The swelling value keeps decreasing with the increase of fly ash content, and adding cement to fly ash-soft soil mixture can further minimize the swelling value by two times compared to only fly ash as the stabilizing agent.