bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospection of Indigenous Yeasts from Uruguayan Tannat Vineyards with a View to Their Oenological Applications
Authors: Morera Guillermo , de Ovalle Stefani , -Pombo Paula Gonzalez 
Published: March 2022

Abstract
Prospection of yeasts from oenological environments can provide knowledge of new native strains that are capable of ferment must and positively influence the composition and sensory characteristics of the wine. This work is addressed to the biotechnological characterization of indigenous yeast of Tannat must, an emblematic and widespread vineyard of Uruguay. Fifty-three yeast strains were morphologically characterized and further identified by amplification and sequencing of ITS and D1-D2 regions, grouping into a total of fifteen species. A representative strain of each species was selected and evaluated for its technological traits. In presence of ethanol (6 to 16% v/v) and SO2 (40 mg/L), native Saccharomyces cerevisiae T19-3FS presented the best growth rates and minors lag phase. Of the non-Saccharomyces strains, S. bacillaris T19-3MS stood out for its behavior in vinification conditions, more closely related with Saccharomyces strains. S. cerevisiae T19-3FS, S. bacillaris T19-3MS, S. diversa T19-1FS and P. terricola T19-1FN conducted a successful fermentation process reaching final ethanol concentration ≥ 10% v/v, and showed K + R phenotype, highlighting its potential use in pure starter cultures for the production of finished wines. It also notes that S. diversa T19-1FS exhibits BGL activity making it interesting to explore its possible activity onto non-volatile glycosides during fermentation, to enhance aromatic compounds. Regarding the rest of the NS yeast studied, they could be good candidates for use in mixed-fermentations with Saccharomyces.
Trends and Timing of Interventions in Management of Acute Gallstone Pancreatitis in the United States
Authors: Chkhikvadze Tamta , Bashir Muhammad , Uwagbale Ese , Kwak Ye Eun , Shi Junxin , Vignesh Shivakumar 
Published: March 2022

Abstract
Background: Only about 50% of acute gallstone pancreatitis admissions undergo index cholecystectomy.Aims: We aimed to analyze the national trends in acute gallstone pancreatitis management: the proportion and optimal timing of cholecystectomy. Methods: Adult admissions with acute gallstone pancreatitis and associated procedures were extracted from National Inpatient Sample (2005-2014yy). Patients with index cholecystectomy were identified and divided into early and delayed intervention groups. Trends, complications, mortality, and hospital resource utilization were analyzed. Results: In 991,476 acute gallstone pancreatitis hospitalizations, the rate of index cholecystectomy remained low at 53-55%. Analysis of cholecystectomy complications and resource utilization demonstrated the safest and most cost-effective strategy is to perform cholecystectomy during 24-72 hours of admission. A risk difference of 12.6% in the complication rate was observed between early (<72hrs) versus delayed (>72hrs) cholecystectomy groups. Delay in cholecystectomy to day five or beyond was associated with significantly higher morbidity, mortality, and resource utilization. Conclusion: The rate of index cholecystectomies to prevent recurrent acute gallstone pancreatitis remains significantly low nationally (53-55%). Our analysis demonstrates that cholecystectomy should be avoided in the first 24 hours, and optimal timing for intervention is from 24 to 72 hours of acute gallstone pancreatitis hospitalization. Careful patient selection and timing of definitive operative management are important to ensure the best clinical outcomes and avoid unnecessary healthcare expenses.
Exploration of bimetallic Au@Ag Core-Shell Nanocubes Dimers supports plasmonic Fano resonances
Authors: Maati Lamia Abu El , Alkallas Fatemah. H. , Trabelsi Amira Ben Gouider , Elaissi Samira , Alrebdi Tahani A. , Ahmad Mahmoud 
Published: March 2022

Abstract
We report a theoretical simulation of optical spectra of Au@Ag core/shell nanocubes dimers. The influence of the core/shell size ratio and the dimers separation gap on these spectra have been studied using boundary element method (BEM). The scattering sections of various core/shell size ratio (= 10–80%) with different separation gap (2 to 16 nm) have been numerically determined via Maxwell equations. We have examined the scattering sections along a wide wavelengths range, 250–1500 nm, in visible and IR domain. The edge lengths of 60, 80, 100 and 120 nm of the shell nanocubes have been considered. We revealed the formation of Fano resonance line shape through the investigation of the scattering section variation within the entire wavelengths. The Fano resonance line shape emerges with the variation of the gap between the dimer as well as of the core/shell size ratio. The trace of the Fano interference dip is slightly blue shifted and it is lost above gap separation equal 4 nm. The core/shell dimer with varied core/shell size ratio manipulate and image easily the trace of the Fano resonance dip up to core/shell size ratio equal 50% for gap separation above 4 nm. We demonstrate the important duality of the gap separation and core/shell ratio variation in designing Fano resonance interface. This has a potential effect on applications in nonlinear optics, metamaterial, tunable nanophotonic devices such as filters, wave-guiding, subwavelength optical imaging, chemical and biological sensing.
The Difference in Kinematic Parameters During Gait Between the Patients with Knee Osteoarthritis and Healthy Controls Using an Insole with a Single Inertial Measurement Unit: A Case-Control study
Authors: Yaguchi Haruki , Honda Keita , Sekiguchi Yusuke , Chenhui Huang , Kenichiro Fukushi , Zhenwei Wang , Kentaro Nakahara , Kamimura Masayuki , Aki Takashi , Ogura Ken , Izumi Shin-Ichi 
Published: March 2022

Abstract
Background: Gait disturbance is a critical problem in patients with osteoarthritis of the knee (KOA). The inertial measurement unit (IMU) is small size and lightweight allows for the measurement of patients without physical constraints. The purpose of this study was to investigate whether an insole with a single IMU can detect differences in kinematic parameters during gait between patients with KOA and healthy controls.Methods: Twenty patients with KOA, for whom unilateral total knee arthroplasty was planned, and 13 age-matched control subjects were included in this study. Participants wore shoes with IMU-equipped insoles and were required to walk across an 8-m walkway at a self-selected speed and foot movement data were collected during gait. We compared the spatiotemporal and kinematic parameters on the right side in healthy controls and both sides in patients with KOA.Results: The self-selected walking speed and stride length in the KOA group were significantly lower than those of the controls. The foot extension angular velocity at the toe-off (TO) was significantly smaller on the affected side than on the contralateral side (p<0.001) and in the healthy controls (p<0.001). During the swing phase, foot forward acceleration was significantly smaller on the affected side of KOA compared with healthy controls (p=0.005). Furthermore, foot upward acceleration at the initial contact (IC) in patients with KOA was significantly lower on the contralateral side compared with that of healthy controls (p=0.0167) but not on the affected side (p=0.344), despite a decrease in walking speed. Conclusions:The insole with a single IMU can detect differences in foot kinematics during gait between patients with KOA and healthy controls. Our findings indicate that patients with KOA exhibit a dysfunction of the push-off at TO and shock absorption at the IC on the affected side.
Implementation of a Reference Center for Inborn Errors of Immunity in Latin America
Authors: Ain Ana Carolina da Matta , Barreiros Lucila Akune , Aranda Carolina Sanchez , Neto Antonio Condino 
Published: March 2022

Abstract
We would like to report our experience in the deployment of an Immunology outpatient clinic that over 14 years became a Reference Center for Inborn Errors of Immunity (IEI) in Brazil, which is located in the city of Taubaté, in the region of Vale do Paraíba, state of São Paulo, responsible for serving a region of approximately 2.5 million inhabitants. During this period, we participated in the pilot project to implement neonatal screening for severe combined immunodeficiency and initiated courses for physicians from basic health units, implementation of classes on clinical immunology in the undergraduate program of medicine, implementation of an outpatient clinic at the city's Faculty of Medicine, in addition to the assessment of patients hospitalized in emergency and intensive care units. Thus, the implementation of a Reference Center for IEI in Latin America proved to be viable and can serve as a model for other services to be initiated. Based on our experience, we suggest some itens for additional IEI centers to emerge.
Study on machining characteristics with variable distribution density micro-texture tools in turning superalloy GH4202
Authors: Yu Xin , Wang Yongguo , Lv Dejin , Ye Zi , Gao Yuan 
Published: March 2022

Abstract
Micro texture tool (MTT) with variable distribution density was proposed, and the novel MTT can adapt to different friction states in the tool chip contact area and maintain good anti-friction and wear resistance. The novel MTTs were composed of two regions with different groove width and distribution density which were prepared on the rake face by femtosecond laser technology. The cutting process were carried out in turning superalloy GH4202. According to the machining characteristics (rake wear, tool wear volume, workpiece material adhesion volume and the chip morphology), the role of variable distribution density in turning were analyzed. The experimental results show that the texture parameters of the texture region near and away from the edge have different effects and mechanisms on the machining characteristics. Compared with non textured tool and uniform textured tool, the proper design of texture parameters of variable distribution density texture can make the MTT have better wear resistance and chip breaking ability when turning superalloy GH4202.
Behavioral problems as a risk factor for Alopecia Areata and another skin disease: a case-control study in Iran
Authors: shahini Najmeh , Derakhshanpour Firoozeh , salami zanireh , kazemian kimia , Vaghari GholamReza 
Published: March 2022

Abstract
Background: Alopecia areata is a dermatological disorder that is more prevalent among the pediatric population. This disease has been linked to behavioral problems in both pediatrics and adults. However, the behavioral problems of the pediatric population have not been widely studied. The present study aimed to evaluate the behavioral problems among the pediatric population in the north of Iran. methods: This case-control study was carried out on the 90 children aged 4-13 who have been chosen by simple sampling and equally enrolled in three study groups; Alopecia areata, another skin disease, and healthy children. The parent’s version of the strengths and difficulties questionnaire (SDQ) was used, and P<0.05 is considered a significant level. Results: The mean age of the patients with Alopecia, other diseases, and healthy population were 9.27, 8.43, and 9.93 years, respectively. The total difficulty score was not significantly different between the alopecia patients and patients with other diseases (p=0.137). The total difficulty score was significantly different among those with alopecia areata and those with other diseases and the healthy population (p=0.003 and p=0.045). Emotional symptoms of conduct problems and peer relationship problems were common in children with alopecia areata compared to the healthy population (p=0.004, p=0.019, and p< 0.001, respectively). Conclusions: The pediatric patients with alopecia areata have an increased level of behavioral problems compared to the healthy population. Therefore, pediatric patients with alopecia areata need psychiatric assessments alongside treating their dermatologic concerns.
Dramatic Efficacy of Interferon and Vemurafenib on Psychiatric Symptoms Revealing BRAFV600E Mutated Erdheim-Chester Disease
Authors: Jérôme Razanamahery , Maroua Abdallahoui , Guillaume Chabridon , Agnès Fromont , Georges Tarris , Ahmed Idbaih , Olivier Comby Pierre , Francois Godard , Julien Haroche , Sylvain Audia , Bernard Bonnotte 
Published: March 2022

Abstract
Erdheim-Chester disease (ECD) is a rare histiocytosis with underestimated neurological involvement. Neurological manifestations are heterogenous depending on disease location and mechanisms, but psychiatric symptoms have not been described to date in the clinical spectrum of neuro-ECD. An 81-year-old woman was referred to the hospital because of delirium with auditive and visual hallucinations, severe cognitive impairment and cerebellar syndrome. Brain magnetic resonance imaging showed FLAIR hyperintensity lesions in the pons, upper cerebellum peduncles. Blood and cerebrospinal fluid (CSF) analysis were normal except for an elevated neopterin level in the CSF. Whole-body CT scan (18FDG-PET) showed peri-nephric fat infiltration and aorta adventitia sheathing with radiotracer uptake in the pons, vessels, peri-nephric fat, and bone lesions, which were characteristic of ECD. The diagnosis was confirmed on perirenal tissue biopsy, which also showed a BRAFV600E mutation. Treatment with interferon resulted in resolution of delirium, and BRAF inhibitor subsequently resulted in partial remission of all active sites. This case highlights that delirium can be the first manifestation of neurodegenerative ECD. Interferon and targeted therapy appear to be effective in this situation.
The Pattern of Cardiovascular Disease Risks Among Working People (18-64 Years) via a Nationwide Household-Based Survey in Malaysia
Authors: Awaluddin S Maria , Lin Chong Zhuo , Kuay Lim Kuang , Shawaluddin Nor Syaqilah , Lah Tuan Amin Tuan , Robat Rosnawati Muhamad , Mahjom Maznieda , Yussof Muhammad Fadhli Mohd 
Published: March 2022

Abstract
Background
Cardiovascular diseases (CVDs) is prevalent globally and it is increasing tremendously. The article aimed to determine the prevalence and the odds ratio of seven type of diseases/ risk factors which contribute to CVDs among working people (18–64 years) in Malaysia.
Methods
A cross-sectional study among a nationally representative sample in Malaysia was conducted using a validated questionnaire. Clinical procedures were done by registered nurses to measure glucose, cholesterol, body mass index and blood pressure. The prevalence and prevalence odds ratio were calculated via complex samples data analysis of IBM SPSS Statistics version 25.
Results
The overall prevalence of CVD risks among working people were 14.1%, 17.3%, 24.5%, 28.8%, 31.7%, 45.9% and 94.2%, for diabetes, obesity, hypertension, physically inactive, tobacco smoker, hypercholesterolemia and inadequate fruit and vegetable (FV) intake, respectively. This study found that older age was associated with the odds of having the most CVD risks. Males were associated with higher odds of having hypertension and tobacco smoker, whereas females were more likely to have hypercholesterolemia, obesity, and physical inactivity. Those who worked as the manager & senior officials, clerical workers and services & sales workers were physically inactive while workers from the lower educational level were more likely to smoke tobacco. Workers in public sector were more likely to have a higher prevalence of diabetes, hypertension, hypercholesterolemia, smoking and obesity than workers in private sector.
Conclusions
This study highlighted that working people have significant CVD risks and the best intervention should be conducted at workplace settings.
Predicting Early Failure of Quantum Cascade Lasers During Accelerated Burn-in Testing Using Machine Learning
Authors: Aydinkarahaliloglu A. Cagri , Jatar Shashank , Wang Xiaojun , Fong Mary , Gupta Vijay , Troccoli Mariano , Hoffman Anthony J. 
Published: March 2022

Abstract
Device life time is a significant consideration in the cost of ownership of quantum cascade lasers (QCLs). The life time of QCLs beyond an initial burn-in period has been studied previously; however, little attention has been given to predicting premature device failure where the device fails within several hundred hours of operation. Here, we demonstrate how standard electrical and optical device measurements obtained during an accelerated burn-in process can be used in a simple support vector machine to predict premature failure with high confidence. For every QCL that fails, at least one of the measurements is classified as belonging to a device that will fail prematurely—as much as 205 hours before the actual failure of the device. Furthermore, for devices that are operational at the end of the burn-in process, the algorithm correctly classifies all the measurements. This work will influence future device analysis and could lead to insights on the physical mechanisms of premature failure in QCLs.
A randomized, double-blind, placebo-controlled 12-Week trial of Infliximab in patients with Juvenile-Onset Spondyloarthritis or Enthesitis Related Arthritis
Authors: Burgos-Vargas Rubén , Loyola-Sanchez Adalberto , Ramiro Sofia , Reding-Bernal Arturo , Gutiérrez-Suárez Raul , Casasola-Vargas Julio C. , Alvarez-Hernandez Everardo , Heijde Désirée Van der , Vazquez-Mellado Janitzia 
Published: March 2022

Abstract
Objective. To assess the efficacy and safety of infliximab versus placebo in the treatment of patients with Juvenile-onset Spondyloarthritis and enthesitis-related arthritis (JoSpA/ERA). Methods. Phase III, randomised, double-blind, placebo-controlled-trial of 12-weeks that included patients <18-year-old with JoSpA/ERA not-responding to nonsteroidal-anti-inflammatory drugs, sulfasalazine, or methotrexate. Patients were randomly assigned 1:1 to the infusion of Infliximab 5mg/kg or placebo; completers entered then an open-label extension (OLE) period of 42 weeks. The primary endpoint was the number of active joints. Secondary outcomes included the assessment of disease activity, tender entheses, spinal mobility, serum C reactive protein (CRP), the Bath Ankylosing Spondylitis Disease Activity and Functional Index, and the Childhood Health Assessment Questionnaire (CHAQ). Results. We randomized 12 patients to Infliximab and 14 to placebo. No significant differences were found between groups at baseline. At week 12, the mean number of active joints was 1.4 (SD 2.4) in the Infliximab group and 4.1 (SD 3.0) in the placebo group (p=0.0002). A repeated measures mixed model analysis that included all endpoints in the study demonstrated sustained favourable outcomes of Infliximab for active joints, tender joints, swollen joints and tender entheses counts, as well as for CHAQ and CRP (p<0.01). Adverse events were more frequent in the Infliximab group, including infections and infusion reactions, but none of them were serious.Conclusion. Infliximab is efficacious for patients with JoSpA/ERA with an inadequate response to conventional treatment. No serious adverse events with the use of infliximab were observed.
Investigating the Representation of Heatwaves from an Ensemble of Km-scale Regional Climate Simulations within CORDEX-FPS Convection
Authors: Sangelantoni Lorenzo , Sobolowski Stefan , Lorenz Torge , Hodnebrog Øivind , Cardoso Rita Margarida Cardoso , Soares Pedro , Ferretti Rossella , Lavín-Gullón Alvaro , Fernandez Jesus , Goergen Klaus , Milovac Josipa , Katragkou Eleni , Kartsios Stergios , Coppola Erika , Pichelli Emanuela , Adinolfi Marianna , Mercogliano Paola , Berthou Ségolène , de Vries Hylke , Dobler Andreas , Belušić Danijel , Feldmann Hendrik , Tölle Merja , Bastin Sophie 
Published: March 2022

Abstract
Heatwaves (HWs) are high-impact phenomena that stress both societies and ecosystems. Their intensity and frequency are expected to increase in a warmer climate over many regions of the world. While these impacts can be wide ranging, they are potentially influenced by local to regional features such as topography, land-cover, urbanization. Here, we leverage recent advances in the very high resolution modelling required to elucidate the impacts of heatwaves at these fine scales. Further we aim to understand how the new generation of km-scale regional climate models (RCMs) modulates the representation of heatwaves over a well-known climate change hot spot. We analyze an ensemble of 15 convection-permitting regional climate model (CPRCM, ~ 2–4 km grid spacing) simulations and their driving, convection-parameterized regional climate model (RCM, ~ 12–15 km grid spacing) simulations from the CORDEX Flagship Pilot Study on Convection. The focus is on the evaluation experiments (2000–2009) and three subdomains with a range of climatic characteristics. During HWs, and generally in summer season, CPRCMs exhibit warmer and drier conditions than their driving RCMs. Higher maximum temperatures arise due to an altered heat flux partitioning, with daily peaks up to ~ 150 W/m2 larger latent heat in RCMs compared to the CPRCMs. This is driven by a 5–25% lower soil moisture content in the CPRCMs, which is in turn related to longer dry spell length (up to double). It is challenging to ascertain whether these differences represent an improvement. However, a distribution-based maximum temperature evaluation, suggests that this CPRCMs warmer/drier tendency is likely more realistic compared to the RCMs, with ~ 70% of reference sites indicating an added value compared to the driving RCMs. Certainly, CPRCMs enhance dry conditions, with knock-on implications for summer season temperature overestimation, especially over flat terrains. Whether this improved physical representation of HWs also has implications for future changes is under investigation.
Citric acid production by a novel autochthonous Candida zeylanoides isolate: Optimization of process parameters
Authors: BÖREKÇİ BILGE SAYIN , Kaya Mükerrem , Göksungur Yekta , Kaban Güzin 
Published: March 2022

Abstract
In this study, citric acid production by autochthonous Candida zeylanoides 7.12 was investigated and optimized. Response surface methodology (RSM) was used for the analysis of simultaneous effects of the chosen factors and two experiment designs were applied. In the first experimental design, the effects of initial pH value (5.5-6.5), fermentation time (4-6 days) and initial glucose concentration (125-175 g/L) on citric acid production were investigated. Initial pH value was adjusted periodically with NaOH. Results of the statistical analysis showed that the model was found to be not applicable sufficiently to the chosen data. A second experimental design was employed by keeping the pH constant at pH 6.5 using glucose concentration and fermentation time as the process parameters to be optimized. Results of the statistical optimization showed that the fit of the model was good and the lack of fit was not significant at the 5 % (P<0.05). The highest citric acid concentration of 11.36 g/L was obtained after 6 days of fermentation with an initial glucose concentration of 125 g/L. The results indicated that initial glucose concentration and fermentation time were important parameters for citric acid production by C. zeylanoides 7.12 and this strain could be used for future studies.