bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibiotic exposure and acquisition of antibiotic-resistant gram-negative bacteria among outpatients at a US Veterans Affairs medical center
Authors: Akpoji Ukwen C. , Wilson Brigid M. , Briggs Janet M. , Song Sunah , Bej Taissa A. , Perez Federico , Jump Robin L. P. 
Published: January 2022

Abstract

Objectives:
To assess the prevalence of antibiotic-resistant gram-negative bacteria (R-GNB) among patients without recent hospitalization and to examine the influence of outpatient antibiotic exposure on the risk of acquiring R-GNB in this population.

Design:
2-year retrospective cohort study.

Setting:
Regional Veterans Affairs healthcare system.

Patients:
Outpatients at 13 community-based clinics.

Methods:
We examined the rate of acquisition of R-GNB within 90 days following an outpatient visit from 2018 to 2019. We used clinical and administrative databases to determine and summarize prescriptions for systemic antibiotics, associated infectious diagnoses, and subsequent R-GNB acquisition among patients without recent hospitalizations. We also calculated the odds ratio of R-GNB acquisition following antibiotic exposure.

Results:
During the 2-year study period, 7,215 patients had outpatient visits with microbiological cultures obtained within 90 days. Of these patients, 206 (2.9%) acquired an R-GNB. Among patients receiving antibiotics at the visit, 4.6% acquired a R-GNB compared to 2.7% among patients who did not receive antibiotics, yielding an unadjusted odds ratio of 1.75 (95% confidence interval, 1.18–2.52) for a R-GNB following an outpatient visit with versus without an antibiotic exposure. Regardless of R-GNB occurrence, >50% of antibiotic prescriptions were issued at visits without an infectious disease diagnosis or issued without documentation of an in-person or telehealth clinical encounter.

Conclusions:
Although the rate of R-GNBs was low (2.9%), the 1.75-fold increased odds of acquiring a R-GNB following an outpatient antibiotic highlights the importance of antimicrobial stewardship efforts in outpatient settings. Specific opportunities include reducing antibiotics prescribed without an infectious diagnosis or a clinical visit.
A framework and road map for rapid start-up and completion of a COVID-19 vaccine trial: A single clinical trial site experience
Authors: Rojas Carlos , Spector Stephen A. , Cale Bernadette , Loughran Megan , Lazaro Leander , Mah Eric , Firestein Gary S. , Gold Kathryn A. , Wallace Mark 
Published: January 2022

Abstract
The COVID-19 global pandemic required the rapid development of vaccines with a quick start up of phase 1–3 studies with large enrollment targets. The University of California San Diego was identified as a site for the phase 3 trial of the mRNA-1273-SARS-CoV-2 vaccine. There were many challenges with scaling up a large-scale clinical trial in such a short time. This report describes the processes and procedures that were implemented to successfully complete the enrollment target in under 10 weeks. This required the team to identify existing tools that could rapidly be accessed to develop a database, scheduling system, effective communication, document management, staff time tracking/efficiency, subject scheduling/tracking, project management, and accrual/study performance. The outcome of these efforts resulted in rapid enrollment and study completion in a short time. The lessons learned from this experience can be used by other clinical trial sites faced with similar challenges.
Diversity, Trust, and Conformity: A Simulation Study
Authors: Fazelpour Sina , Steel Daniel 
Published: January 2022

AbstractPrevious simulation models have found positive effects of cognitive diversity on group performance, but have not explored effects of diversity in demographics (e.g., gender, ethnicity). In this paper, we present an agent-based model that captures two empirically supported hypotheses about how demographic diversity can improve group performance. The results of our simulations suggest that, even when social identities are not associated with distinctive task-related cognitive resources, demographic diversity can, in certain circumstances, benefit collective performance by counteracting two types of conformity that can arise in homogeneous groups: those relating to group-based trust and those connected to normative expectations toward in-groups.
Resolving the Raven Paradox: Simple Random Sampling, Stratified Random Sampling, and Inference to Best Explanation
Authors: Ward Barry 
Published: January 2022

AbstractSimple random-sampling resolutions of the raven paradox relevantly diverge from scientific practice. We develop a stratified random-sampling model, yielding a better fit and apparently rehabilitating simple random sampling as a legitimate idealization. However, neither accommodates a second concern, the objection from potential bias. We develop a third model that crucially invokes causal considerations, yielding a novel resolution that handles both concerns. This approach resembles Inference to the Best Explanation (IBE) and relates the generalization’s confirmation to confirmation of an associated law. We give it an objective Bayesian formalization and discuss the compatibility of Bayesianism and IBE.
Perspectival Instruments
Authors: Creţu Ana-Maria 
Published: January 2022

AbstractDespite its potential implications for the objectivity of scientific knowledge, the claim that “scientific instruments are perspectival” has received little critical attention. I show that this claim is best understood as highlighting the dependence of instruments on different perspectives. When closely analyzed, instead of constituting a novel epistemic challenge, this dependence can be exploited to mount novel strategies for resolving two old epistemic problems: conceptual relativism and theory-ladeness. The novel content of this article consists in articulating and developing these strategies by introducing two fine-grained notions of perspectives as the key units of analysis: “broad perspectives” and “narrow perspectives.”
What Makes Behavioral Measures of Consciousness Subjective and Direct?
Authors: Jonkisz Jakub 
Published: January 2022

AbstractThis article addresses two issues: the distinction between objective and subjective measures and the directness of such measures. It is argued that the distinction is unambiguous only when based on a methodological criterion (i.e., the threshold utilized by the measures) rather than a semantic one (i.e., their referring either to the world or to the participant’s inner states). Different senses of directness are discussed: metaphysical (which seems to rest on a category error), methodological (the only unambiguously defined one, though relating “directly” to performance rather than awareness), semantic (which appears gradable), and causal.
Assessing fitness costs of the resistance of Spodoptera frugiperda (Lepidoptera: Noctuidae) to pyramided Cry1 and Cry2 insecticidal proteins on different host plants
Authors: Garlet Cínthia G. , Muraro Dionei S. , Godoy Daniela N. , Cossa Gisele E. , Hanich Manoela R. , Stacke Regis F. , Bernardi Oderlei 
Published: January 2022

AbstractFall armyworm (FAW), Spodoptera frugiperda (Smith), is one of the major pests targeted by transgenic crops expressing insecticidal proteins from Bacillus thuringiensis (Bt) Berliner. However, FAW presents a high capacity to develop resistance to Bt protein-expressing crop lines, as reported in Brazil, Argentina, Puerto Rico and the southeastern U.S. Here, FAW genotypes resistant to pyramided maize events expressing Cry1F/Cry1A.105/Cry2Ab2 (P-R genotype) and Cry1A.105/Cry2Ab2 (Y-R genotype) from Brazil were used to investigate the interactions between non-Bt hosts (non-Bt maize, non-Bt cotton, millet and sorghum) and fitness costs. We also tested a FAW genotype susceptible to Bt maize and F1 hybrids of the resistant and susceptible genotypes (heterozygotes). Recessive fitness costs (i.e., costs affecting the resistant insects) were observed for pupal and neonate to adult survival of the P-R genotype on non-Bt cotton; larval developmental time of the P-R genotype on millet and sorghum; larval and neonate-to-adult developmental time of the Y-R genotype on non-Bt cotton and sorghum; the fecundity of the Y-R genotype on non-Bt cotton; and mean generation time of both resistant genotypes. However, on non-Bt cotton and non-Bt maize, the P-R genotype had a higher fitness (i.e., fitness benefits), displaying greater fecundity and rates of population increases than the Sus genotype. Non-recessive fitness costs (i.e., costs affecting heterozygotes) were found for fecundity and population increases on millet and sorghum. These findings suggest that, regardless of the disadvantages of the resistant genotypes in some hosts, the resistance of FAW to Cry1 and Cry2 Bt proteins is not linked with substantial fitness costs, and may persist in field conditions once present.
THE CORPORATE GROUP: SYSTEM, DESIGN AND RESPONSIBILITY
Authors: Witting Christian 
Published: January 2022

AbstractLungowe v Vedanta Resources plc presages more liberal criteria for determining when a parent company owes a duty of care to third parties injured by subsidiary activities. It invokes systems language and points to potential parent company liability for omissions in managing the group. This article develops these ideas. It portrays the corporate group in systems-managerial terms. The parent creates group-wide structures and deploys management strategies and integrating mechanisms that facilitate achievement of its purposes. It has a substantial causal influence upon subsidiary acts and omissions. Prima facie the parent cannot avoid extended liability claims by hiding behind the “pure omissions” rule.
International Solidarity and the Global Compact on Refugees: What Role for the African Union and the European Union?
Authors: Nicolosi Salvatore F , Momoh Solomon 
Published: January 2022

AbstractOn the 70th anniversary of the UN Refugee Convention, this article examines the concept of solidarity and explains its relevance today, through the lens of the Global Compact on Refugees (GCR). While stressing the potential as well as the challenges for thorough implementation of the solidarity mechanisms established by the GCR, the article argues that regional organizations may contribute to meeting the GCR objectives. This is particularly urgent for regions that are most affected by migratory flows. In proposing new ways of approaching the concept of solidarity, the article suggests that the African Union strengthen mechanisms other than the physical sharing of refugees, including pooling resources to support states experiencing large influxes of refugees. In addition to a system of financial support for refugee protection, the article also recommends that the European Union ensures safe channels for arrivals and a more robust resettlement programme, to help realize the GCR objectives.
Comparative proteomic analysis of hybrid maize MR2008 and its parental lines
Authors: Osawa-Martínez E. E. , Minjarez B. , Rodríguez-Yáñez Y. , Reza-Zaldivar E. E. , Canales-Aguirre A. A. , Mena-Munguía S. 
Published: January 2022

AbstractMaize is one of the three staple foods in the world. The white variety represents 60% of the maize importation with a world consumption of 1125 million tons in 2019/2020. Currently, new technologies could contribute to the analysis of this seed, supporting quality control and improvement. This study aims to carry out the morphological and proteomic comparison between the hybrid MR2008 and its parental lines LUG03 and CML491 through mass spectrometry and bioinformatics analysis. Herein, we identified that 34.8% of the hybrid proteome differs from the parental proteome. Also, ontological and morphological analyses determined that the hybrid exhibits more characteristics related to CML491 than LUG03, for example, metabolic pathways and enzymes, such as anthocyanidin 3-O-glucosyltransferase (UniProt P16166). This analysis allowed the identification of dominant characters, metabolic pathways and confirms the utility of this methodology in agricultural practices, mainly in processes of selection and quality control of a crop.
Improvement of Cercospora leaf spot and powdery mildew resistance of mungbean variety KING through marker-assisted selection
Authors: Papan P. , Chueakhunthod W. , Jinagool W. , Tharapreuksapong A. , Masari A. , Kaewkasi C. , Ngampongsai S. , Girdthai T. , Tantasawat P. A. 
Published: January 2022

AbstractThe development of resistant mungbean varieties is one of the most efficient strategies to control major diseases such as Cercospora leaf spot (CLS) and powdery mildew (PM). The objectives of this study were to pyramid a CLS resistance gene and two PM resistance genes from the donor parent D2 into a susceptible variety KING through marker-assisted backcrossing (MABC) and to evaluate their agronomic traits and disease resistance under field conditions. Five markers linked to the resistance genes were used for foreground selection, while two marker sets [Set A containing 15 polymorphic simple sequence repeat (SSR) and expressed sequence tag-SSR (EST-SSR) markers and Set B containing 34 polymorphic inter-simple sequence repeat (ISSR) loci] were also used for background selection. Two pyramided backcross (BC) lines, namely H3 and H4, were homozygous at all five marker loci when confirmed in BC4F4 and BC4F5 generations. Their recurrent parent genome (RPG) recovery ranged from 96.4 to 100.0%, depending on the marker sets. During field evaluation, a moderate to high level of CLS and PM resistance was observed in both BC lines compared to the susceptible recurrent parent KING. One of these BC lines (H3) had all agronomic traits similar or superior to the recurrent parent KING at all environments, and had a higher yield than KING (18.0–32.0%) under CLS and PM outbreaks. This line can be developed into a new resistant mungbean variety in Thailand in the future. These results substantiate the usefulness of MABC for transferring multiple resistance genes into an elite variety.
Implications of updated protocol for classification of childhood malnutrition and service delivery in world’s largest refugee camp amid this COVID-19 pandemic
Authors: Anwar Afsana , Mondal Probal Kumar , Yadav Uday Narayan , Shamim Abu Ahmed , Rizwan Abu Ansar Md. , Mistry Sabuj Kanti 
Published: January 2022

AbstractObjectives:During the COVID-19 pandemic, the authorities made a change in the classification of malnutrition and concomitant service delivery protocol among the Rohingya children, residing in world’s largest refugee camp, located in Cox’s Bazar, Bangladesh. In this paper, we discussed the potential implications of this updated protocol on the malnutrition status among children residing in the Rohingya camps.Design:This paper reviewed relevant literature and authors’ own experience to provide a perspective of the updated protocol for the classification of malnutrition among the children in the Rohingya camps and its implication from a broader perspective.Setting:Rohingya refugee camps, Bangladesh.Participants:Children aged less than five years residing in the Rohingya camps.Results:Major adaptation during this COVID-19 was the discontinuation of using weight-for-height z-score (WHZ) and the use of only mid upper arm circumference (MUAC) and presence of oedema for admission, follow-up and discharge of malnourished children in the camps. However, evidence suggests that use of MUAC only can underestimate the prevalence of malnutrition among the children in Rohingya camps. These apparently non-malnourished children are devoid of the rations that they would otherwise receive if classified as malnourished, making them susceptible to more severe malnutrition.Conclusions:Our analysis suggests that policymakers should consider using the original protocol of using both MUAC and WHZ to classify malnutrition and retain the guided ration size. We also believe that it would not take an extra effort to adopt the original guideline as even with MUAC only guideline, certain health measures needed to adopt during this pandemic.
Genetic liability to rheumatoid arthritis on autism and autistic traits: polygenic risk score and Mendelian randomization analyses
Authors: Ly Amanda , Leppert Beate , Rai Dheeraj , Jones Hannah , Dardani Christina , Stergiakouli Evie 
Published: January 2022

AbstractHigher prevalence of autism in offspring born to mothers with rheumatoid arthritis has been reported in observational studies. We investigated (a) the associations between maternal and offspring’s own genetic liability for rheumatoid arthritis and autism-related outcomes in the offspring using polygenic risk scores (PRS) and (b) whether the effects were causal using Mendelian randomization (MR). Using the latest genome-wide association (GWAS) summary data on rheumatoid arthritis and individual-level data from the Avon Longitudinal Study of Parents and Children, United Kingdom, we constructed PRSs for maternal and offspring genetic liability for rheumatoid arthritis (single-nucleotide polymorphism [SNP] p-value threshold 0.05). We investigated associations with autism, and autistic traits: social and communication difficulties, coherence, repetitive behaviours and sociability. We used modified Poisson regression with robust standard errors. In two-sample MR analyses, we used 40 genome-wide significant SNPs for rheumatoid arthritis and investigated the causal effects on risk for autism, in 18,381 cases and 27,969 controls of the Psychiatric Genetics Consortium and iPSYCH. Sample size ranged from 4992 to 7849 in PRS analyses. We found little evidence of associations between rheumatoid arthritis PRSs and autism-related phenotypes in the offspring (maternal PRS on autism: RR 0.89, 95%CI 0.73–1.07, p = 0.21; offspring’s own PRS on autism: RR 1.11, 95%CI 0.88–1.39, p = 0.39). MR results provided little evidence for a causal effect (IVW OR 1.01, 95%CI 0.98–1.04, p = 0.56). There was little evidence for associations between genetic liability for rheumatoid arthritis on autism-related outcomes in offspring. Lifetime risk for rheumatoid arthritis has no causal effects on autism.
Targeted memory reactivation of face-name learning depends on ample and undisturbed slow-wave sleep
Authors: Whitmore Nathan W. , Bassard Adrianna M. , Paller Ken A. 
Published: January 2022

AbstractFace memory, including the ability to recall a person’s name, is of major importance in social contexts. Like many other memory functions, it may rely on sleep. We investigated whether targeted memory reactivation during sleep could improve associative and perceptual aspects of face memory. Participants studied 80 face-name pairs, and then a subset of spoken names with associated background music was presented unobtrusively during a daytime nap. This manipulation preferentially improved name recall and face recognition for those reactivated face-name pairs, as modulated by two factors related to sleep quality; memory benefits were positively correlated with the duration of stage N3 sleep (slow-wave sleep) and negatively correlated with measures of sleep disruption. We conclude that (a) reactivation of specific face-name memories during sleep can strengthen these associations and the constituent memories, and that (b) the effectiveness of this reactivation depends on uninterrupted N3 sleep.
Application of convolutional neural networks for prediction of disinfection by-products
Authors: Peleato Nicolás M. 
Published: January 2022

AbstractFluorescence spectroscopy can provide high-level chemical characterization and quantification that is suitable for use in online process monitoring and control. However, the high-dimensionality of excitation–emission matrices and superposition of underlying signals is a major challenge to implementation. Herein the use of Convolutional Neural Networks (CNNs) is investigated to interpret fluorescence spectra and predict the formation of disinfection by-products during drinking water treatment. Using deep CNNs, mean absolute prediction error on a test set of data for total trihalomethanes, total haloacetic acids, and the major individual species were all < 6 µg/L and represent a significant difference improved by 39–62% compared to multi-layer perceptron type networks. Heat maps that identify spectral areas of importance for prediction showed unique humic-like and protein-like regions for individual disinfection by-product species that can be used to validate models and provide insight into precursor characteristics. The use of fluorescence spectroscopy coupled with deep CNNs shows promise to be used for rapid estimation of DBP formation potentials without the need for extensive data pre-processing or dimensionality reduction. Knowledge of DBP formation potentials in near real-time can enable tighter treatment controls and management efforts to minimize the exposure of the public to DBPs.
Oligosaccharide equine feed supplement, Immulix, has minor impact on vaccine responses in mice
Authors: Henriksen Ida Wang , Mejia Josue Leonardo Castro , Mentzel Caroline Martha Junker , Lindenberg Frederikke , Hansen Axel Kornerup 
Published: January 2022

AbstractSeveral mammalian species are vaccinated in early life, but little is known about the effect of diet on vaccine response. Oligosaccharides are increasingly proposed as dietary supplement for young individuals due to their anti-inflammatory potential elicited through modulation of gut microbiota (GM). Also, diet, e.g. the size of the fat fraction, is known to modulate the GM. We tested if an oligosaccharide diet (Immulix) and/or increased dietary fat content affected antibody titers to a tetanus vaccine in 48 BALB/cJTac mice through GM modulation. Female mice had significantly higher IgG titers with higher variation compared to male mice. The effects of Immulix and/or increased fat content were minor. Immulix negatively affected IgG titers in male mice four weeks after secondary vaccination but upregulated Il1b gene expression in the spleen. Immulix had a downregulating effect on expression of Cd4 and Foxp3 in ileum only if the mice were fed the diet with increased fat. The diet with increased dietary fat increased Il1b but decreased Cd8a gene expression in the spleen. Immulix and diet affected GM composition significantly. Increased dietary fat content upregulated Lactobacillus animalis but downregulated an unclassified Prevotella spp. Immulix decreased Lactobacillales, Streptococcaceae and Prevotellaceae but increased Bacteroides. It is concluded that in spite of some minor influences on immune cell markers, cytokines and IgG titers Immulix feeding or increased dietary fat content did not have any biologically relevant effects on tetanus vaccine responses in this experiment in mice.
Diamond and methane formation from the chemical decomposition of polyethylene at high pressures and temperatures
Authors: Watkins E. B. , Huber R. C. , Childs C. M. , Salamat A. , Pigott J. S. , Chow P. , Xiao Y. , Coe J. D. 
Published: January 2022

AbstractPolyethylene (C2H4)n was compressed to pressures between 10 and 30 GPa in a diamond anvil cell (DAC) and laser heated above 2500 K for approximately one second. This resulted in the chemical decomposition of the polymer into carbon and hydrocarbon reaction products. After quenching to ambient temperature, the decomposition products were measured in the DAC at pressures ranging from ambient to 29 GPa using a combination of x-ray diffraction (XRD) and small angle x-ray scattering (SAXS). XRD identified cubic diamond and methane as the predominant product species with their pressure–volume relationships exhibiting strong correlations to the diamond and methane equations of state. Length scales associated with the diamond products, obtained from SAXS measurements, indicate the formation of nanodiamonds with a radius of gyration between 12 and 35 nm consistent with 32–90 nm diameter spherical particles. These results are in good agreement with the predicted product composition under thermodynamic and chemical equilibrium.