bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe weather disasters in China linked to solar activity during 1-1825 Common Era
Authors: Liu Jann-Yenq , Chen Yuh-Ing , Lee Po-Han , Huang Chi-Shen , Fang Tzu-Wei 
Published: March 2022

AbstractHistorical records truthfully document human life and environment associated with climate changes. We quantify official historical records of China dating back last 2000 years to examine the disasters due to anomalous temperatures of cold or hot, irregular precipitations of wet or dry, and floods in inland/coastal or Northern/Southern areas in four seasons that possibly linked to solar activities during 1-1825 CE (Common Era). It is found that the proportion of disaster years is positively associated with the time periods, and therefore, both the cases with high and low solar activity (HSA and LSA) leading are under study. Statistical results show that extreme cold weather occurs particularly in the Winter and Spring during LSA periods. Irregularities precipitations, including heavy rain/hail/snow and severe drought are significantly frequent during LSA periods, while floods on inland and coastal river basins tend to occur more frequently in LSA and HSA periods, respectively. The disasters owing to irregularities precipitations and floods frequently happen in Summer and Autumn, which suggests that the irregular precipitations could cause the floods. All the disasters occur significantly in the Northern China, which suggests the climate boundary of the Qinling–Huaihe Line along at about 33°N being essential. In total, all the disasters due to the anomalously cold temperatures, irregular precipitations, and floods tend to occur during the LSA periods.
Development and feasibility testing of a physical activity intervention for youth with anxiety and depression: a study protocol
Authors: Kodal Arne , Muirhead Fiona , Reilly John J. , Wergeland Gro Janne H. , Thorsen Paul Joachim Bloch , Bovim Lars Peder , Elgen Irene Bircow 
Published: March 2022

Abstract
Background
Anxiety and depressive disorders in children and adolescents are highly prevalent and account for more than half of all youth psychiatric disorders. Left untreated, anxiety, and depression lead to numerous detrimental outcomes, including reduced quality of life, psychiatric, and somatic comorbidity and even reduced lifespan. This puts a large strain on child and adolescent mental healthcare services (CAMHS) to provide effective treatments. However, even when provided the best evidence-based treatment, between 40–50% of patients continue to report significant symptom burdens. Thus, there is an immediate need for supplemental and/or new treatment approaches. Physical activity as a supplementary treatment may be such an approach. However, research investigating this approach within this population is scant. This protocol paper describes the development and feasibility trial of a physical activity-based intervention targeting anxiety and depressive symptoms in youth treated in CAMHS.

Methods/design
The study is based on the UK Medical Council Research Framework (MRC) for developing and evaluating complex interventions. Feasibility and acceptability of the physical activity intervention (confident, active, and happy youth) will be evaluated in an uncontrolled open-label trial using qualitative and quantitative data. Twenty youths with anxiety and/or depressive symptoms will be recruited. Acceptability of assessment procedures, the intervention, and perceived benefits and barriers to participation will be assessed, and qualitative interviews with participants, caregivers, and referring specialists will explore contextual and practical factors associated with intervention delivery. Physical activity will be measured using the Actigraph GT3X+ monitor at baseline, and post-intervention and change in anxiety and depression will be assessed.

Discussion
This study will contribute to the development of supplementary physical treatment interventions for youth with anxiety and depression in contact with CAMHS. The goal is to examine new avenues of treatment that ultimately may improve upon current treatment outcomes of anxiety and depression. This work will be in preparation for a future definitive randomized controlled trial (RCT) of this approach, in line with the MRC Framework.

Trial registration
ClnicalTrials.gov, NCT05049759. Registered on August 19, 2021. Retrospectively registered.
Multiple ways for the same destination: bone regeneration
Authors: Kim Seong-Gon 
Published: March 2022

AbstractThe regeneration of the bone is a challenging topic for maxillofacial plastic and reconstructive surgeons. For successful bone regeneration, timely providing of essential components is prerequisite. They are cellular components (osteoblasts, osteoclasts, and immune cells), extracellular matrix, and inorganic components (calcium and phosphate). Any deficient component can be provided from outside as a graft. Accordingly, there are many ways for successful bone regeneration. Selection of appropriate methods in an individualized situation is important.
Efficacy of low-fat milk and yogurt fortified with vitamin D3 on systemic inflammation in adults with abdominal obesity
Authors: Sharifan Payam , Rashidmayvan Mohammad , Khorasanchi Zahra , Darroudi Susan , Heidari Azam , Hoseinpoor Fatemeh , Vatanparast Hassan , Safarian Mohamad , Eslami Saeid , Afshari Asma , Asadi Zahra , Ghazizadeh Hamideh , Bagherniya Mohammad , Khedmatgozar Hamed , Ferns Gordon , Rezaie Mitra , Mobarhan Majid Ghayour 
Published: March 2022

Abstract
Background
The prevalence of vitamin D deficiency is increasing globally and is associated with an increased risk of metabolic syndrome, autoimmune disease, and cardiovascular disease. Vit D deficiency is also associated with increased systemic inflammation. The current study aimed to determine the efficacy of low-fat milk and yogurt fortified with 1500 IU nano-encapsulated vitamin D, on systemic inflammation in abdominal obese participants.

Method
This multi-center study was conducted using a 2.5-month parallel total-blind randomized clinical trial design. Two hundred and eighty nine subjects were allocated to four groups: low-fat milk fortified by 1500 IU nano-encapsulated vitamin D3 (200 mL/day). Simple milk (200 mL/day), low-fat yogurt fortified by 1500 IU nano-encapsulated vitamin D3 (150 g/day), and simple yogurt (150 g/day).

Results
The results showed that serum levels of neutrophils, lymphocytes, platelets and red blood cell distribution width (RDW) were significantly lower before and after the intervention in fortified dairy groups. The results showed that serum levels of neutrophils, lymphocytes, platelets, and RDW before and after intervention in the fortified dairy groups were significantly lower (p < 0.05). The values of = neutrophil to lymphocyte ratio (NLR), platelets to lymphocyte ratio, and RDW to platelets ratio (RPR) reduced significantly in the fortification group (p < 0.05).

Conclusion
Fortification with nano-encapsulated vitamin D3 of dairy products may decrease inflammation in individuals with abdominal obesity.
Electrical power behavioral usage in public institutions and its intervention: a case of tanzania higher learning institutions
Authors: Bazila Simon , Kalinga Ellen , Ibwe Kwame , Abdalla Abdi T. 
Published: March 2022

AbstractPublic institutions in developing countries, taking Tanzania as an example, are facing huge electricity consumption bills caused by inefficient utilization of electrical power. The causes of inefficient power usage can be due to the users’ behavioral and inadequacy of technology deployment in electric controlling infrastructure. This study explores the users’ behavior and the consequences of inefficient power utilization in Tanzania Higher Learning Institutions (HLIs). Around 85% of the sampled participants in the selected HLIs were least concerned with power saving strategies while using office facilities. The study reveals that inefficient energy consumption may result in high electrical power bills, unnecessary energy waste, psychological effects caused by inability to pay electrical bills and distress resulting from frequent power outages. Besides, the study proposes both behavioral- and technological-based interventions for electrical power saving in HLIs.
Gene polymorphisms of Interleukin 6 (−174 G/C) and transforming growth factor β-1(+915 G/C) in ovarian cancer patients
Authors: Almolakab Zainab M. , El-Nesr Khalid A. , Mohamad Hassanin Ehab Hassanin , Elkaffas Rasha , Nabil Ahmed 
Published: March 2022

Abstract
Background
In the study on hand, we investigated the effect of IL-6 (−174 G/C; rs 1800795) and TGF-β1 (+915G/C; rs 1800471) gene polymorphisms on the susceptibility to Ovarian Cancer and their effect on plasma levels. IL-6 (−174 G/C) SNP was analyzed using mutagenically separated polymerase chain reaction (MS-PCR) while TGF-β1 +915G/C (codon 25) SNP was investigated by the sequence-specific primer polymerase chain reaction (SSP-PCR). An enzyme-linked immunosorbent assay (ELISA) was used to quantify IL-6 and TGF-β1 plasma levels in 48 ovarian cancer patients and 48 normal controls.

Results
Regarding IL 6 (−174 G/C), a significant increase in CC and GC+CC genotypes parallel with the C allele was considered as risk factors for ovarian cancer; on the other hand, the G allele was considered as a protective factor for ovarian cancer. TGF-β1 (+915G/C) investigations showed a significant elevation in GC and GC+CC genotypes which can be considered as a risk factor for ovarian cancer. Plasma IL-6 and TGF-β1 were higher in ovarian cancer patients compared with controls. No specific genotype or allele could be responsible for the elevation of TGF-β1 in ovarian cancer patients’ plasma, while the highest significant value for IL6 in subjects carrying GG and CC genotypes in comparison with GC genotype.

Conclusions
This study supports an association of IL6 (−174G/C) and TGF-β1 (+915G/C) gene polymorphisms with the susceptibility to ovarian cancer.
Evaluation of periostin, fibronectin and tenascin-C in patients chronic otitis media with cholesteatoma
Authors: Birinci Mehmet , Terzi Suat , Demir Emine , Çeliker Metin , Okçu Oğuzhan , Arpa Medeni , Çelebi Özlem , Özergin Zerrin , Dursun Engin 
Published: March 2022

Abstract
Background
Although many studies have investigated the mechanisms of cholesteatoma formation, its pathogenesis remains unclear. The aim of this study was to evaluate the levels of periostin, fibronectin and tenascin-C, which are involved in many mechanisms, such as cell adhesion, cell differentiation, inflammation, fibrosis, angiogenesis and cell proliferation, in patients with chronic otitis media (COM). A total of 80 participants, 65 COM patients undergoing surgery and 15 healthcare personnel volunteers serving as controls, were included in this study. The participants were divided into four groups: cholesteatoma, granulation, avivation and control group. The serum periostin, fibronectin and tenascin-C levels of all participants were determined biochemically. Histopathological evaluation of tissue samples and 20 skin samples used as controls was performed by immunohistochemistry.

Results
Of the 65 patients, 22 presented with cholesteatoma, 15 with granulation tissue and 28 with the edge of the tympanic membrane perforation freshening tissue. There were no significant differences in serum periostin, fibronectin and tenascin-C levels between the groups. In the immunohistochemical evaluation, fibronectin and periostin staining was significantly more intense in the cholesteatoma group than in the other groups (p = 0.001). Epithelial tenascin-C staining was significantly more intense in the avivation group than in the other groups (p = 0.041).

Conclusion
The levels of periostin and fibronectin were higher in cholesteatoma tissue than in other forms of chronic otitis and skin tissue. This suggests that they may be involved in the mechanism of cholesteatoma formation. These proteins could be used as biomarkers in the diagnosis and treatment of cholesteatoma.
Is it really about freedom of thought?
Authors: Drescher Jack 
Published: March 2022

SummaryThis opinion piece responds to Marcus Evans's ‘Freedom to Think’ regarding treating adolescents diagnosed with gender dysphoria (DSM)/gender incongruence (ICD). Evans notes not everything is known about GD/GI, particularly its ‘causes’. Although correct, he presents this fact as a rationale for delaying treatment for all children presenting with GD/GI symptoms. However, Marcus does not specify how long such prolonged evaluations should last nor does he have much of an evidence base to support his recommendation. This author believes delaying treatment for GD/GI adolescents who need it for the benefit of children who ‘aren’t really’ transgender is an ethically troubling issue.
Same-Cell Co-Occurrence of RAS Hotspot and BRAF V600E Mutations in Treatment-Naive Colorectal Cancer
Authors: Gularte-Mérida Rodrigo , Smith Shaleigh , Bowman Anita S. , da Cruz Paula Arnaud , Chatila Walid , Bielski Craig M. , Vyas Monika , Borsu Laetitia , Zehir Ahmet , Martelotto Luciano G. , Shia Jinru , Yaeger Rona , Fang Fang , Gardner Rui , Luo Ruibang , Schatz Michael C. , Shen Ronglai , Weigelt Britta , Sánchez-Vega Francisco , Reis-Filho Jorge S. , Hechtman Jaclyn F. 
Published: March 2022

PURPOSE Mitogen-activated protein kinase pathway–activating mutations occur in the majority of colorectal cancer (CRC) cases and show mutual exclusivity. We identified 47 epidermal growth factor receptor/BRAF inhibitor-naive CRC patients with dual RAS hotspot/ BRAF V600E mutations (CRC-DD) from a cohort of 4,561 CRC patients with clinical next-generation sequencing results. We aimed to define the molecular phenotypes of the CRC-DD and to test if the dual RAS hotspot/BRAF V600E mutations coexist within the same cell. MATERIALS AND METHODS We developed a single-cell genotyping method with a mutation detection rate of 96.3% and a genotype prediction accuracy of 92.1%. Mutations in the CRC-DD cohort were analyzed for clonality, allelic imbalance, copy number, and overall survival. RESULTS Application of single-cell genotyping to four CRC-DD revealed the co-occurrence of both mutations in the following percentages of cells per case: NRAS G13D/ KRAS G12C, 95%; KRAS G12D/ NRAS G12V, 48%; BRAF V600E/ KRAS G12D, 44%; and KRAS G12D/ NRAS G13V, 14%, respectively. Allelic imbalance favoring the oncogenic allele was less frequent in CRC-DD (24 of 76, 31.5%, somatic mutations) compared with a curated cohort of CRC with a single-driver mutation (CRC-SD; 119 of 232 mutations, 51.3%; P = .013). Microsatellite instability–high status was enriched in CRC-DD compared with CRC-SD (23% v 11.4%, P = .028). Of the seven CRC-DD cases with multiregional sequencing, five retained both driver mutations throughout all sequenced tumor sites. Both CRC-DD cases with discordant multiregional sequencing were microsatellite instability–high. CONCLUSION Our findings indicate that dual-driver mutations occur in a rare subset of CRC, often within the same tumor cells and across multiple tumor sites. Their presence and a lower rate of allelic imbalance may be related to dose-dependent signaling within the mitogen-activated protein kinase pathway.
The analysis of efficiency for high-dimensional quantum secure direct communications under atmospheric turbulence
Authors: Niu Jialei , Liu Xin-Chang 
Published: March 2022

Abstract
Recently, there is a tremendous attention on the high-dimensional quantum information processing using the orbital angular momentum (OAM) of photons. It provides an efficient method to increase the capacity of quantum channel. However, OAM is very vulnerable to atmospheric turbulence, resulting in phase distortion and, therefore, leading to information leakage during quantum communications. On the other hand, quantum secure direct communications (QSDC) define an efficient way of information exchange through quantum channels directly. Here in this work, by combining the applications of OAM states of photons as the information carrier with the QSDC, we analyze the performance of the high-dimensional quantum secure direct communication protocol based on encoding the information on the single photon OAM state under the condition of free space channel. Numerically, we discussed the performance of OAM states QSDC under atmospheric turbulence, and mainly calculated the influence of cross-talk caused by phase fluctuation on the system. We draw the conclusion that under the weak turbulence, when the beam waist

and the Fried parameter r become comparable, the information capacity will decrease sharply.
Prefixed-threshold real-time selection for free-space phase-matching quantum key distribution
Authors: Yu Yang , Wang Le , Zhao Shengmei , Mao Qianping 
Published: March 2022

Abstract
Phase-matching quantum key distribution (PM-QKD), a practical version of twin-field quantum key distribution (TF-QKD), is able to surpass the linear bound without quantum repeaters. Implementing PM-QKD through free space can guarantee two parties to share unconditionally secure keys between ground stations and mobile platforms. However, atmospheric turbulence (AT) in the free-space channel would decrease the secure key rate (SKR) since it would cause fluctuations of transmittances. Two works we do are presented in this paper. First, for simplicity and generality, we derive the SKR for 4-intensity PM-QKD with asymmetric channel transmittances. Secondly, we apply the observable model of the prefixed-threshold real-time selection (P-RTS) method to mitigate the effect of AT in PM-QKD. Here, the authorized parties predetermine the threshold of transmittances and use it to select the signals while monitoring the real-time transmittances. The results show that the performance of PM-QKD in free space is severely degraded by AT, while P-RTS can reduce the impact of AT, making it transmit more than 3 times as long the distance and have a 3.37 times as large SKR at a distance of 50 km.
Metastatic Differentiated Thyroid Cancer Survival Is Unaffected by Mode of Preparation for 131I Administration
Authors: Gomes-Lima Cristiane J , Chittimoju Sanjita , Wehbeh Leen , Dia Sunita , Pagadala Prathyusha , Al-Jundi Mohammad , Jhawar Sakshi , Tefera Eshetu , Mete Mihriye , Klubo-Gwiezdzinska Joanna , Van Nostrand Douglas , Jonklaas Jacqueline , Wartofsky Leonard , Burman Kenneth D 
Published: March 2022

Abstract

Context
Recombinant human thyrotropin (rhTSH) is currently not Food and Drug Administration approved for the treatment of high-risk patients with differentiated thyroid cancer (DTC).

Objective
The goal of our study was to compare the outcomes in higher-risk patients with metastatic DTC prepared for radioiodine (RAI) therapy with rhTSH vs thyroid hormone withdrawal (THW).

Methods
A retrospective chart review was performed of patients with metastatic DTC in follow-up at MedStar Washington Hospital Center and MedStar Georgetown University Hospital from 2009 to 2017. Patients were divided according to their preparation for RAI therapy, with assessment of progression-free survival (PFS) and overall survival (OS).

Results
Fifty-five patients with distant metastases (16 men, 39 women) were prepared for RAI therapy exclusively either with rhTSH (n = 27) or with THW (n = 28). There were no statistically significant differences between the groups regarding clinicopathological features and history of RAI therapies. The median follow-up time for patients with rhTSH-aided therapies was 4.2 years (range, 3.3-5.5 years) and for patients with THW-aided therapies was 6.8 years (range, 4.2-11.6 years) (P = .002). Multivariate analysis showed that the method of thyrotropin stimulation was not associated with a difference in PFS or OS.

Conclusion
As has been shown previously for low-risk DTC, this study indicates that the mode of preparation for RAI therapy does not appear to influence the outcomes of patients with metastatic DTC. PFS and OS were similar for patients with THW-aided or rhTSH-aided RAI therapies.
Attenuated Metabolic and Cardiorespiratory Responses to Isoenergetic High-Intensity Interval Exercise of Short Versus Long Bouts
Authors: BOGDANIS GREGORY C. , STAVRINOU PINELOPI S. , TSIRIGKAKIS SPYRIDON , MOUGIOS VASSILIS , ASTORINO TODD A. , MASTORAKOS GEORGE 
Published: March 2022

ABSTRACT

Purpose
To compare the metabolic, cardiorespiratory and perceptual responses to three isoenergetic high-intensity interval exercise (HIIE) protocols of different bout duration and an isoenergetic continuous exercise protocol.

Methods
Eleven healthy males (age, 28 ± 6 yr) performed four 20-min cycling trials of equal mean power output 1 wk apart. Participants cycled either continuously (CON) or intermittently with 10 s (HIIE10), 30 s (HIIE30), or 60 s (HIIE60) bouts at intensities corresponding to 49% (CON) or 100% of power at peak oxygen uptake (V̇O2peak). Recovery intervals during the HIIE trials were 15, 45, and 90 s, respectively.

Results
Average V̇O2 was similar in the HIIE trials (2.29 ± 0.42, 2.20 ± 0.43, and 2.12 ± 0.45 L·min−1, for HIIE10, HIIE30, and HIIE60, respectively), whereas in CON (2.02 ± 0.38 L·min−1), it was lower than HIIE10 (P = 0.002) and HIIE30 (P = 0.043). Average pulmonary ventilation (VE) was higher in HIIE60 compared with HIIE10, HIIE30, and CON (75.8 ± 21.8 L·min−1 vs 64.1 ± 14.5 L·min−1, 64.1 ± 16.2 L·min−1, and 54.0 ± 12.5 L·min−1, respectively, P < 0.001). The peak values and oscillations of V̇O2 and VE in HIIE60 were higher compared with all other trials (P < 0.001). Blood lactate concentration was higher in HIIE60 compared with HIIE10, HIIE30, and CON from the fifth minute onward, reaching 12.5 ± 3.5, 7.2 ± 2.1, 7.9 ± 2.9, and 4.9 ± 1.6 mmol·L−1, respectively, at the end of exercise (P < 0.001). RPE was higher and affective responses were lower in HIIE60 compared with all other trials toward the end of exercise (P < 0.001).

Conclusions
These findings highlight the importance of bout duration in HIIE, since shorter bouts resulted in attenuated metabolic and cardiorespiratory responses, lower RPE and feelings of displeasure compared with a longer bout, despite equal total work, duration, and work-to-recovery ratio. These results may have implications for the prescription of HIIE in various populations.