bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Plant Secondary Metabolites for the Prevention of Skin Cancers
and their Mechanism: A Review
Authors: Kadian Jai Parkash , Kaushik Madan Lal , Chauhan Bhupendra , Singh Aniruddh Dev 
Published: June 2022

Abstract:
Skin carcinoma is the most common malignancy, including malignant melanoma and
non-malignant melanoma throughout the world, and in the last three decades, its incidences have
been increasing drastically. High cost, severe side effects and development of resistance from conventional
chemotherapy have decreased its acceptability and increased the urge for the search for
alternate options. Therefore, plant derived phytochemicals have come up with cost effectiveness,
ease of availability and promising potential for skin related cancers. In spite of the lack of clinical
data involving humans to support the positive effects of phytochemicals on different types of skin
cancers, topical application of these plant derived anticancer phytochemicals is extremely promising.
Many mechanisms and pathways underlie the antitumor activity of plant-derived phytochemicals
, such as loss of mitochondrial membrane potential, the release of cytochrome-c, suppression of
antiapoptotic proteins and induction of proapoptotic proteins, activation of caspases, Fas, FADD and
p53 signaling pathway, inhibition of Akt signaling pathway, phosphorylation of ERK, P13K, Raf,
survivin gene, STAT 3 and NF-kB. The use of cell line models in the in vitro study of skin cancer
offers the opportunity to identify the mechanisms of action of plant derived phytochemicals against
various types of skin cancer. As such, this article aims at providing a comprehensive review of plant
extracts and phytochemicals, which have been reported to exhibit promising anti-carcinogenic properties
in animal models and against various skin cancer cell lines.
Pengembangan Modul Pembelajaran Penggunaan ArcGIS Online untuk Pembuatan Peta Penyebaran Gedung: Studi Kasus pada Peta Penyebaran SMK Kompetensi Keahlian DPIB di Daerah Istimewa Yogyakarta
Authors: Sukmantari Hanna Nursanti , Marsudi Ilham , Raharjo Nuryadin Eko 
Published: June 2022

ABSTRACTThe purpose of this study was to develop a learning module for the use of ArcGIS Online in making the distribution map of the SMK DPIB expertise program in DIY in the Geomatics Practicum II course in the Department of Civil Engineering and Planning UNY. This research is included in research and development or Research and Development (RD), the 4D (four-D) method by Thiagarajan. The data collection technique spreads questionnaires to respondents. Qualitative descriptive technique as a data analysis technique. The results of this study are: (1) The development of learning media through the 4D stage. The defining stage (Define) is to obtain the needs in using ArcGIS Online., The selected media design stage is the learning module, the development stage (Develop) stage is validated by material experts, and media experts then a feasibility test is carried out on the user ,, and the dissemination stage (Disseminate), the dissemination stage is carried out by spreading the media that has been developed. The learning media developed is a learning module. The feasibility of the learning module is based on the assessment of the material expert, namely 3.93 with the "Feasible" category, media experts of 4.77 with the "Very Appropriate" category, and the user feasibility test of 4.23 with the "Very Appropriate" category.Keywords: ArcGIS Online, Learning Module, DevelopmentABSTRAKTujuan dari penelitian ini adalah untuk mengembangkan modul pembelajaran penggunaan ArcGIS Online dalam pembuatan peta sebaran SMK program keahlian DPIB di DIY pada mata kuliah Praktikum Geomatika II di Jurusan Pendidikan Teknik Sipil dan Perencanaan UNY. Penelitian ini termasuk ke dalam penelitian dan pengembangan atau Research and Development (RD), menggunakan metode 4D (four-D) oleh Thiagarajan. Teknik pengumpulan data menggunakan menyebar angket kepada responden. Teknik yang digunakan berupa deskriptif kualitatif sebagai teknik analisis data. Hasil penelitian mendapatkan hasil yaitu Pengembangan media pembelajaran melalui tahap 4D. Tahap pendefinisian (Define) adalah untuk memperoleh kebutuhan penggunaan ArcGIS Online, tahap perancangan (Design) media yang dipilih yaitu modul pembelajaran, tahap pengembangan (Develop) tahap ini dilakukan validasi ahli materi, dan ahli media kemudian dilakukan uji kelayakan kepada pengguna, dan tahap penyebaran (Disseminate), tahap penyebaran dilakukan dengan menyebarkan media yang telah dikembangkan. Media pembelajaran yang dikembangkan adalah modul pembelajaran. Kelayakan modul pembelajaran berdasarkan penilaian dari ahli materi, yaitu 3,93 dengan kategori “Layak”, untuk ahli media sebesar 4,77 dengan kategori “Sangat Layak”, sdangkan uji kelayakan pengguna sebesar 4,23 dengan kategori “Sangat Layak”.
Worldwide Presence of National Anesthesia Societies on Four Major Social Networks in 2021: Observational Case Study
Authors: Clavier Thomas , Occhiali Emilie , Guenet Claire , Vannier Naurine , Hache Camille , Compere Vincent , Selim Jean , Besnier Emmanuel 
Published: June 2022

Background
Although the presence of medical societies on social networks (SNs) could be interesting for disseminating professional information, there is no study investigating their presence on SNs.

Objective
The aim of this viewpoint is to describe the worldwide presence and activity of national anesthesia societies on SNs.

Methods
This observational study assessed the active presence (≥1 post in the year preceding the collection date) of the World Federation of Societies of Anesthesiologists member societies on the SNs Twitter, Facebook, Instagram, and YouTube. We collected data concerning each anesthesia society on the World Federation of Societies of Anesthesiologists website.

Results
Among the 136 societies, 66 (48.5%) had an active presence on at least one SN. The most used SN was Facebook (n=60, 44.1%), followed by Twitter (n=37, 27.2%), YouTube (n=26, 19.1%), and Instagram (n=16, 11.8%). The SN with the largest number of followers was Facebook for 52 (78.8%) societies and Twitter for 12 (18.2%) societies. The number of followers was 361 (IQR 75-1806) on Twitter, 2494 (IQR 1049-5369) on Facebook, 1400 (IQR 303-3058) on Instagram, and 214 (IQR 33-955) on YouTube. There was a strong correlation between the number of posts and the number of followers on Twitter (r=0.95, 95% CI 0.91-0.97; P<.001), Instagram (r=0.83, 95% CI 0.58-0.94; P<.001), and YouTube (r=0.69, 95% CI 0.42-0.85; P<.001). According to the density of anesthetists in the country, there was no difference between societies with and without active SN accounts.

Conclusions
Less than half of national anesthesia societies have at least one active account on SNs. Twitter and Facebook are the most used SNs.
Exploring the Association of Cancer and Depression in Electronic Health Records: Combining Encoded Diagnosis and Mining Free-Text Clinical Notes
Authors: Leis Angela , Casadevall David , Albanell Joan , Posso Margarita , Macià Francesc , Castells Xavier , Ramírez-Anguita Juan Manuel , Martínez Roldán Jordi , Furlong Laura I , Sanz Ferran , Ronzano Francesco , Mayer Miguel A 
Published: June 2022

Background
A cancer diagnosis is a source of psychological and emotional stress, which are often maintained for sustained periods of time that may lead to depressive disorders. Depression is one of the most common psychological conditions in patients with cancer. According to the Global Cancer Observatory, breast and colorectal cancers are the most prevalent cancers in both sexes and across all age groups in Spain.

Objective
This study aimed to compare the prevalence of depression in patients before and after the diagnosis of breast or colorectal cancer, as well as to assess the usefulness of the analysis of free-text clinical notes in 2 languages (Spanish or Catalan) for detecting depression in combination with encoded diagnoses.

Methods
We carried out an analysis of the electronic health records from a general hospital by considering the different sources of clinical information related to depression in patients with breast and colorectal cancer. This analysis included ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification) diagnosis codes and unstructured information extracted by mining free-text clinical notes via natural language processing tools based on Systematized Nomenclature of Medicine Clinical Terms that mentions symptoms and drugs used for the treatment of depression.

Results
We observed that the percentage of patients diagnosed with depressive disorders significantly increased after cancer diagnosis in the 2 types of cancer considered—breast and colorectal cancers. We managed to identify a higher number of patients with depression by mining free-text clinical notes than the group selected exclusively on ICD-9-CM codes, increasing the number of patients diagnosed with depression by 34.8% (441/1269). In addition, the number of patients with depression who received chemotherapy was higher than those who did not receive this treatment, with significant differences (P<.001).

Conclusions
This study provides new clinical evidence of the depression-cancer comorbidity and supports the use of natural language processing for extracting and analyzing free-text clinical notes from electronic health records, contributing to the identification of additional clinical data that complements those provided by coded data to improve the management of these patients.
Analysis of Factors Related to 3R-Based Waste Management Site in Jambi City
Authors: Ningsih Wahyu , Jalius Jalius , Hadi Syafril 
Published: June 2022

The objective of this study is to analysis of factors related to the functioning of 3R-based waste management site in Jambi City. The factors are consists of internal factors and external factors. The internal factors are individual characteristic (age, gender, job status, education, income), knowledge and attitude. The external factors are regulation, community participation and local government support. Design of this study is cross sectional design with 100 respondents as the samples. Proportional stratified random sampling is used as sampling technique and questionnaire is used to collect the data. The result of this study showed that the good functioning of 3R-based waste management site is 56%, and 44% has bad functioning. Based on Chi Square test showed that there were factors related to the functioning of 3R-based waste management site. They were knowledge, attitude, community participation and local government support. Based on linier regression test showed that community participation (95% CI: 0,815-9,661) was the most dominant factor related to the functioning of 3R-based waste management site which are controlled by knowledge, attitude and local government support. The conclusion of this study is to increase the functioning of 3R-based waste management site in Jambi City, the community participation have to developed by increasing the education about waste management with 3R-concept, also the increasing of local goverment support by coaching about the importance of 3R-based waste management site in Jambi City.
Management and Outcomes of Severe Hypoglycemia Treated by Emergency Medical Services in the U.S. Upper Midwest
Authors: Myers Lucas A. , Swanson Kristi M. , Glasgow Amy E. , McCoy Rozalina G. 
Published: June 2022

OBJECTIVE
To examine factors associated with emergency department (ED) transport after hypoglycemia treated by emergency medical services (EMS) and assess the impact of ED transport on severe hypoglycemia recurrence.

RESEARCH DESIGN AND METHODS
We retrospectively analyzed electronic health records of a multistate advanced life support EMS provider and an integrated healthcare delivery system serving an overlapping geographic area in the upper Midwest. For adults with diabetes treated by EMS for hypoglycemia between 2013 and 2019, we examined rates of ED transport, factors associated with it, and its impact on rates of recurrent hypoglycemia requiring EMS, ED, or hospital care within 3, 7, and 30 days.

RESULTS
We identified 1,977 hypoglycemia-related EMS encounters among 1,028 adults with diabetes (mean age 63.5 years [SD 17.7], 55.2% male, 87.4% non-Hispanic White, 42.4% rural residents, and 25.6% with type 1 diabetes), of which 46.4% resulted in ED transport (31.1% of calls by patients with type 1 diabetes and 58.0% of calls by patients with type 2 diabetes). Odds of ED transport were lower in patients with type 1 diabetes (odds ratio [OR] 0.44 [95% CI 0.31–0.62] vs. type 2 diabetes) and higher in patients with prior ED visits (OR 1.38 [95% CI 1.03–1.85]). Within 3, 7, and 30 days, transported patients experienced recurrent severe hypoglycemia 2.8, 5.2, and 10.6% of the time, respectively, compared with 7.4, 11.2, and 22.8% of the time among nontransported patients (all P &lt; 0.001). This corresponds to OR 0.58 (95% CI 0.42–0.80) for recurrent severe hypoglycemia within 30 days for transported versus nontransported patients. When subset by diabetes type, odds of recurrent severe hypoglycemia among transported patients were 0.64 (95% CI 0.43–0.96) and 0.42 (95% CI 0.24–0.75) in type 1 and type 2 diabetes, respectively.

CONCLUSIONS
Transported patients experienced recurrent hypoglycemia requiring medical attention approximately half as often as nontransported patients, reinforcing the importance of engaging patients in follow-up to prevent recurrent events.
Caloric Restriction and Weight Loss Are Primary Factors in the Early Tissue-Specific Metabolic Changes After Bariatric Surgery
Authors: Flynn Charles Robb , Tamboli Robyn A. , Antoun Joseph , Sidani Reem M. , Williams Brandon , Spann Matthew D. , English Wayne J. , Welch E. Brian , Sundaresan Sinju , Abumrad Naji N. 
Published: June 2022

OBJECTIVE
To evaluate changes in insulin sensitivity, hormone secretion, and hepatic steatosis immediately after caloric restriction, vertical sleeve gastrectomy (VSG), and Roux-en-Y gastric bypass (RYGB).

RESEARCH DESIGN AND METHODS
Obese subjects were assessed for 1) insulin sensitivity with hyperinsulinemic-euglycemic clamp with glucose tracer infusion, 2) adipokine concentrations with serum and subcutaneous adipose interstitial fluid sampling, and 3) hepatic fat content with MRI before and 7–10 days after VSG, RYGB, or supervised caloric restriction.

RESULTS
Each group exhibited an ∼5% total body weight loss, accompanied by similar improvements in hepatic glucose production and hepatic, skeletal muscle, and adipose tissue insulin sensitivity. Leptin concentrations in plasma and adipose interstitial fluid were equally decreased, and reductions in hepatic fat were similar.

CONCLUSIONS
The improvements in insulin sensitivity and adipokine secretion observed early after bariatric surgery are replicated by equivalent caloric restriction and weight loss.
Management and Outcomes of Severe Hypoglycemia Treated by Emergency Medical Services in the U.S. Upper Midwest
Authors: Myer Lucas A. , Swanson Kristi M. , Glasgow Amy E. , McCoy Rozalina G 
Published: June 2022

<p> </p>
<p><strong>Objective.</strong> To examine factors associated with emergency department (ED) transport after hypoglycemia treated by emergency medical services (EMS) and assess the impact of ED transport on severe hypoglycemia recurrence.</p>
<p><strong>Research Design and Methods.</strong> We retrospectively analyzed electronic health records of a multi-state advanced life support EMS provider and an integrated healthcare delivery system serving an overlapping geographic area in the Upper Midwest. For adults with diabetes treated by EMS for hypoglycemia between 2013-2019, we examined rates of ED transport, factors associated with it, and its impact on rates of recurrent hypoglycemia requiring EMS, ED, or hospital care within 3, 7, and 30 days.</p>
<p><strong>Results. </strong>We identified 1977 hypoglycemia-related EMS encounters among 1028 adults with diabetes (mean age 63.5 years [SD, 17.7], 55.2% male, 87.4% Non-Hispanic White, 42.4% rural residents, 25.6% with type 1 diabetes) of which 46.4% resulted in ED transport (31.1% of calls by patients with type 1 diabetes and 58.0% of calls by patients with type 2 diabetes). Odds of ED transport were lower in patients with type 1 diabetes (OR 0.44 [95% CI 0.31-0.62] vs. type 2 diabetes) and higher in patients with prior ED visits (OR 1.38 [95% CI 1.03-1.85]). Within 3, 7, and 30 days, transported patients experienced recurrent severe hypoglycemia 2.8%, 5.2%, and 10.6% of the time, respectively, compared to 7.4%, 11.2%, and 22.8% of the time among non-transported patients; all p<0.001. This corresponds to OR 0.58 (95% CI 0.42-0.80) for recurrent severe hypoglycemia within 30 days for transported vs. non-transported patients. When subset by diabetes type, odds of recurrent severe hypoglycemia among transported patients were 0.64 (95% CI 0.43-0.96) and 0.42 (95% CI 0.24-0.75) in type 1 and type 2 diabetes, respectively.</p>
<p><strong>Conclusions. </strong>Transported patients experienced recurrent hypoglycemia requiring medical attention approximately half as often as non-transported patients, reinforcing the importance of engaging patients in follow-up to prevent recurrent events.</p>
Karakteristik Kegiatan Redistribusi Tanah di Kabupaten Pasaman Barat berdasarkan Pemanfaatan untuk Agunan
Authors: Monsaputra Monsaputra , Munibah Khursatul , Panuju Dyah Retno 
Published: June 2022

Reforma agraria bertujuan memperbaiki ketimpangan struktur agraria menjadi lebih berkeadilan melalui redistribusi penguasaan, penggunaan dan pemanfaatan lahan. Kabupaten Pasaman Barat telah mengimplementasikan program redistribusi tanah untuk menata kembali penguasaan, pemilikan, penggunaan dan pemanfaatan tanah. Sertipikat redistribusi tanah dapat digunakan sebagai agunan, tahun 2009-2018 sertipikat redistribusi tanah yang diagunkan sebanyak 871 buah (7,79 %). Penelitian ini bertujuan untuk mengidentifikasi karakteristik kegiatan redistribusi tanah berdasarkan kategori pemanfaatan sertipikat untuk agunan di Kabupaten Pasaman Barat. Metode penelitian yang digunakan adalah metode kuantitatif dengan teknik analisis data dengan analisis spasial melalui overlay peta. Pemanfaatan sertipikat untuk agunan tinggi ditahun pertama setelah pembagian dan cenderung menurun setelahnya. Hasil penelitian memperlihatkan bahwa mayoritas lokasi redistribusi tanah berada pada nilai tanah yang tidak terlalu tinggi dan berada dibawah radius 2 km dari jalan. Lokasi yang diagunkan cenderung lebih banyak pada radius lebih jauh dari pusat pemerintahan, sedangkan lokasi yang belum diagunkan dominan pada radius 40 km dan 60 km dari pusat pemerintahan. Lokasi kegiatan redistribusi tanah mayoritas memiliki luas 1-2 ha perbidang tanah, baik yang diagunkan maupun yang belum diagunkan.
Comparison Normalized Dryness Built-Up Index (NDBI) with Enhanced Built-Up and Bareness Index (EBBI) for Identification Urban in Buleleng Sub-District
Authors: Nuraini Lilis , Nugraha A Sediyo Adi , Yanti Restu Ade , Janah Lutfiatul 
Published: June 2022

The research aims to determine how much accuracy is improved in developing settlements and distinguish the areas built up and vacant land in Buleleng, Bali district. This study used remote sensing methods to monitor and detect changes in the waking area using Landsat 8 OLI imagery. Identify settlement developments using the Normalized Difference Built-up Index (NDBI) and Enhanced Built-Up and Bareness Index (EBBI) algorithms. Both algorithms use red and infrared bands as the basis for identifying building differences. As a result, NDBI and EBBI have differences where the accuracy of EBBI is higher than NDBI by 84% and 82%. The difference in accuracy is influenced by the appearance of vegetation and clay-roofed buildings. Based on that, it can be concluded that in identifying the building, EBBI has a higher capacity compared to NDBI, but it must be ensured that in the use of EBBI, the area studied has a more dominant appearance of the building.
Study on examining the impact of financial support on economic and social empowerment of women in rural areas in Pakistan: a study of BISP-financial support program
Authors: Phulpoto Nazar Hussain , Memon Saifullah , Phulpoto Shumaila 
Published: June 2022

Abstract
The study is to examine the impact of Benazir income support program BISP on women empowerment in Pakistan. BISP is one of the best program initiated by the government of Pakistan. In order to cover and control many social problems of people. It was started to empower women. It provides social security, improve living standard, reduce poverty.
Sample of 300 respondents was used in the study because its area of study was confined to the Khairpur city. It carried out quantitative techniques to measure the impact of BISP on women empowerment for this regression analysis was done and association was explained through Pearson correlation. Finding of this study recommends that there is positive and significant impact of BISP in women empowerment and it has strong correlation with women empowerment. Further questionnaire was designed that was comprised of 24 questions and distributed in BISP beneficiaries to understand its effect. questionnaire was based on 5- point Likert scale. Further hypotheses were also tested and found supported. Entire results were taken through SPSS version 25. In this study the prediction of living standard contributed 35%, poverty alleviation strategy 29% and social security contributed 24%. In this regard it is ensured that government of Pakistan take more effective initiatives to empower not only women but also men.