bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIMULAÇÃO DE PROCEDIMENTOS BÁSICOS PARA ALUNOS DOS PRIMEIROS SEMESTRES DA GRADUAÇÃO EM ENFERMAGEM
Authors: Nascimento Michelle Ingridy Machado do , Beserra Eveline Pinheiro , Teles Liana Mara Rocha , Lima Camila Albuquerque Lima Albuquerque , Sousa Weslley Monteiro Amora , Lima Maria Alzete de 
Published: August 2022

Avaliar a percepção dos estudantes de enfermagem acerca do uso de simulação realística de procedimentos básicos de Enfermagem para alunos do primeiro ano da graduação para aquisição de competências. Este é um estudo quase-experimental. A amostra do estudo foi composta por 49 discentes participantes. A análise dos dados foi realizada por meio do teste de normalidade Shapiro-Wilk e o teste t de Student. Ao analisar, a categoria conhecimento pode-se perceber que tanto na simulação 1 como na simulação 2, o item relacionado ao planejamento das ações obteve maior média. A categoria habilidade nas simulações 1 e 2, obteve maior média relacionada a habilidade em técnicas e procedimentos de enfermagem, mostrando que mesmo nos semestres iniciais, por meio da simulação os alunos se sentiram capacitados a realizar o procedimento. Na categoria atitude, em ambas simulações a maior média foi no item interesse em aprender. Comparando as médias de conhecimento, habilidade e atitude na simulação 1 e 2, pode-se inferir que embora haja diferença entre as médias, do primeiro para o segundo momento, descritas pelo valor t. O p-valor confirma que não há diferença estatisticamente significante entre as médias. A simulação mostrou-se uma ferramenta eficaz de ensino, facilitando a consolidação do conhecimento e despertando maior interesse por parte dos discentes. O uso de práticas simuladas requer capacitação permanente dos docentes para fortalecer o uso dessa metodologia.
Recent Updates in Surgical Treatment of Benign Prostatic Hyperplasia: A Review Article
Authors: Shakya Pawan , Poudel Sagar 
Published: August 2022

Benign prostatic hyperplasia refers to the non-malignant growth or enlargement of the prostate gland and is a general cause of lower urinary tract symptoms in men which rises with growing age. There is a wide range of management options available from watchful waiting, and medicinal therapy to various surgical intervention methods. Though medicinal therapy is the preliminary treatment for benign prostatic hyperplasia, some patients lack the desire to keep on with the extended duration, and on occasion, they must break either due to treatment failure or side effects. Lately, numerous innovative surgical methodologies have been established to provide patients with efficient therapy on a day-care basis, without the risk of general anaesthesia and with rapid recovery, marginal morbidity, and safeguarding the reproductive function. Existing treatment alternatives for benign prostatic hyperplasia differ in the extent of intrusiveness, efficiency, complications, and cost-effectiveness. Various treatment modalities are available these days that are less invasive and have lesser complications as compared to conventional transurethral resection of the prostate. It helps curtail expenses, preserve time for recovery, curb untoward general and reproductive side effects. Laser, endoscopic, robotic, water vapor utilization, and various other minimally invasive methods have demonstrated their effectiveness in the treatment of benign prostatic hyperplasia in various studies.
Non-Thyroidal Illness Syndrome: A Pattern of Thyroid Dysfunction Seen in Intensive Care Unit Patients of a Tertiary Care Centre
Authors: Sah Sanjay Kumar , Gupta Suprita , Marasini Surendra , Yadav Nirdhan , Jha Amit Chandra , Jha Sudhakar , Shrestha Brijesh 
Published: August 2022

Introduction: The response to the endocrine mechanism including thyroid gland hormones to critical illness is a complex phenomenon.1 There is a marked and distinct changes in the levels of thyroid hormones in critical illness.2 The magnitude of the decrease in circulating tri-iodothyronine (fT3) levels (also known as non-thyroidal illness) during the first 24 hour after the onset of acute illness reflects the severity of illness and correlates with mortality. The study aims to evaluate the thyroid function test (TFT) of critically ill patients. The results of the study will be helpful in determining the thyroid picture of the critically ill patients in our setting and definitely help in assessing the outcome of the patient admitted in ICU or ward.
Materials and Methods: This is a hospital based cross sectional study. A total of 150 cases with the critical illness assessed as per Acute Physiology and Chronic Health Evaluation II (APACHE II) score were enrolled in the study from 12th December 2021 to 15th June, 2022. Informed written consent and ethical approval were taken.
Results: The majority of the cases (52%) were of geriatric age group with the mean age of 57 years. Majority of the study participants (42%) in APACHE II were from 20–24 across all participants, and both sexes. Fifty‑one percent of the patients had reduced fT3 levels. There was an increase in percentage of patients with decreased fT3 levels with increasing APACHE II score, compared to normal fT3 levels at similar APACHE II score and the distribution was found to be statistically significant (p = 0.0233). Of the 68 patients expired, 52 of them had low fT3 levels whereas only 16 cases expired were with the normal fT3 level, making it a strong predictor of severity and outcome.
Conclusion: Decrease in the levels of fT3, a condition of non-thyroidal illness, is a crucial prognostic indicator in critically ill patients which in coordination APACHE Score II can be helpful in clinical settings to predict the severity and outcome of such patients.
Empirical Analysis of the Hugh Gray 'Nessie' Photograph
Authors: Watson Roland 
Published: August 2022

The first photograph said to be of the Loch Ness Monster was taken on 12th November 1933 around noon by a local man by the name of Hugh Gray. I say "Loch Ness Monster" because I believe the photograph to be genuine and part of the evidence portfolio. The picture that generally circulates is shown below. The Scottish Daily Record took his picture and Mr. Gray gave the following account to them having been interviewed by Hugh Mackenzie (the future Provost of Inverness), Peter Munro representing Hugh Gray's employers at the British Aluminium Company and a Daily Record staff member:
Four Sundays ago, after church I went for my usual walk near where the river enters the Loch. The Loch was like a mill pond and the sun shining brightly. An object of considerable dimensions rose out of the water not very far from where I was. I immediately got my camera ready and snapped the object which was two or three feet above the surface of the water. I did not see any head, for what I took to be the front parts were under the water, but there was considerable movement from what seemed to be the tail, the part furthest from me. The object only appeared for a few minutes then sank out of sight.
A contemporary picture of Hugh Gray was printed later which I don't think flatters him much but is shown below to show you the man behind the monster.
The tenor of the account suggests some throwing up of spray and water as the presumed tail beat about the waters and hence caused some blurriness around that region of the picture. Mackenzie described Gray as a man highly respected by his fellow workmen, employers and locals. Likewise, the Daily Record had the negative examined by four experts who deemed it as untampered. It caused a stir, was panned by zoologists and faded along with general Nessie-lore as the World entered war six years later. Twenty-two years on, Nessie author, Constance Whyte, visited Hugh Gray in May 1955 who was sticking to his story and still had vivid memories of that day plus he also recounted five other times he claimed to have seen the monster over those decades. Renowned monster hunter, Tim Dinsdale, also recounts how he visited Gray in April 1960 and described him as "a most courteous individual" as he took him to the spot of the sighting[4]. He spoke with "complete conviction" about that day as well as maintaining an accuracy of his account. He also added some detail of his other sightings which partly consisted of rapidly moving bow waves with no visible cause. What remains of the photograph today is uncertain.
L’effet des cégeps du Québec sur le nombre total d’années de scolarité
Authors: Fortin Pierre , Mishagina Natalia , Royer Jimmy 
Published: August 2022

Nous décrivons la réforme collégiale des années 1960 au Québec et nous étudions l’effet initial de la création des cégeps sur la scolarisation des jeunes Québécois en la comparant à celle des jeunes Ontariens. Nous suivons les grandes tendances de la fréquentation scolaire et de l’obtention de diplômes au niveau postsecondaire de 1960 à 2018. Puis nous estimons l’effet de l’arrivée des cégeps sur le nombre total d’années de scolarité des premières cohortes touchées. Une analyse de différence de différences appliquée aux hommes et aux femmes francophones et anglophones au moyen des microdonnées du Recensement de 2001 nous permet d’estimer que l’effet initial des cégeps a été globalement positif et substantiel.
Biografia e educação: aspectos histórico-teórico-metodológicos
Authors: Xavier Antônio Roberto , Vasconcelos José Gerardo , Xavier Lisimére Cordeiro do Vale 
Published: August 2022

Este artigo tem como enfoque principal promover o debate sobre as pesquisas de cunho biográfico, em geral, e especificamente educacional. Como é praxe nas pesquisas científicas, este estudo teve como fio condutor as seguintes querelas problematizadoras: as pesquisas biográficas devem ser consideradas e aceitas no mundo acadêmico como científicas? Se forem, que critérios devem ser seguidos? Visando atender a referida demanda, esta escrita de gênero teórico é do tipo descritiva, quanto ao objetivo, e qualitativa, quanto à abordagem. Como procedimento técnico, adota-se a pesquisa bibliográfica em fontes secundárias por meio de revisão de literatura. Como técnica interpretativa das fontes, emprega-se a análise do discurso. Em conclusão, a priori, as pesquisas biográficas se apresentaram como possibilidade ímpar para dar visibilidade às ações e atuações de sujeitos sociais anônimos, inclusive de professores(as), em todos os níveis, incluindo os(as) leigos(as), de pouca ou de nenhuma formação no campo intelectual, pois, o que se investigam são suas práticas educativas e a realidade social do contexto delimitado.
Adentrando aos arquivos: formação e aspectos da atuação docente de Pórcia Guimarães Alves (1917-1962)
Authors: Ribeiro Alexandra Ferreira Martins 
Published: August 2022

A professora Pórcia Guimarães Alves, nascida em 1917 e falecida em 2005, dedicou boa parte de seu tempo à educação. Pórcia teve acesso a uma formação educacional e docente privilegiada, possibilitada tanto por sua família quanto pelo Estado. O período de sua instrução elementar, até a conclusão do curso de Pedagogia, foi marcado pela paulatina inserção dos conhecimentos científicos da Sociologia, da Biologia e da Psicologia, intuindo o desenvolvimento de novos padrões em educação e na especialização científica dos professores. Pórcia enfatizou os estudos da Psicologia ligada às questões educacionais, no Curso de Pedagogia e em congressos e cursos complementares. Seus conhecimentos da Psicologia aplicados à Educação concretizaram-se nas ações que transitaram entre sua docência, na Universidade Federal do Paraná, com a instalação e a direção do Centro de Estudos e Pesquisas Educacionais (CEPE), da Escola Mercedes Stresser e do Instituto Decroly. Logo, nesse estudo, procurou-se responder ao questionamento: como se deu a formação e a atuação docente de Pórcia Guimarães Alves, entre o período de 1917 a 1962? Elencaram-se os objetivos específicos: identificar, na composição familiar de Pórcia, elementos que colaboraram para sua formação docente; pesquisar as influências institucionais na sua formação docente; e investigar a formação complementar, a inserção profissional e alguns aspectos da atuação docente de Pórcia. Nessa perspectiva, a pesquisa seguiu o caminho da busca bibliográfica e documental, com abordagem qualitativa. Como aporte teórico-metodológico, foi basilar o estudo de Viñao Frago (1995) sobre a possibilidade de estudos na História da Educação por meio da História Cultural; Goodson (1992), no que tange à integração do professor e a pessoa do professor em um único ser, e de Loriga (2011) acerca das perspectivas da biografia na historiografia. Ao longo de sua vida, Pórcia constituiu um diversificado acervo de documentos que variaram desde dados de seus familiares, informações e certificados de seu período escolar, diários, recortes de jornais, cartas, publicações, até pesquisas que compõem um extenso arquivo pessoal. Para a análise desses documentos,a pesquisa valeu-se dos estudos de Gomes (2004) e Farge (2009) e da análise de conteúdo proposta por Bardin (2015). Quanto à utilização da memória como fonte histórica, foi importante a contribuição dos conceitos de “arquivar a própria vida”, de Artières (1998), e de “memória silenciada”, de Pollak (1989). Para a contextualização histórica, cultural, social, econômica e política da pesquisa, deram apoio os estudos realizados por Miguel (1997); Maluf e Mott (1998); Gomes (1999; 2013); Del Priore (2005); Souza (2008) e Vieira (2015; 2017). As análises dos documentos evidenciaram que a formação docente de Pórcia foi resultado de sua vontade de ser rofessora,somada ao ambiente proporcionado por sua família e pelo Estado.
Eu... Uma pesquisadora narrativa: aprendendo a pensar e escrever narrativamente
Authors: Souza Valeska Virgínia Soares 
Published: August 2022

Nesta pesquisa autobiográfica, narro e componho sentidos do meu percurso de pesquisadora, permeado de tensões, de incertezas e de aprendizagem. Meu objetivo inicial foi compreender narrativamente a experiência de me constituir uma pesquisadora narrativa, ao aprender a pensar e a escrever narrativamente. Um desdobramento desse primeiro objetivo, ao narrar a experiência e redigir o texto de pesquisa, foi perceber como são algumas interações entre os membros de um grupo de pesquisa, ou comunidade responsiva. Meu trabalho foi norteado pelas premissas da pesquisa narrativa, segundo Clandinin e Connelly (2000; 2015), dentre outros pesquisadores. Inicio este artigo com minha narrativa, apresentando-me e descrevendo o meu contexto: como fui provocada a viver uma história de pesquisa embasada nos pressupostos teórico-metodológicos da pesquisa narrativa. Posteriormente, narro o meu entrar no entremeio da pesquisa narrativa. Conto histórias vividas nos encontros do grupo de pesquisa, apontando para a importância da prática e do aspecto relacional, e histórias que vivi como parecerista e como organizadora de eventos, reconhecendo minha antiga concepção de busca por verdades e a transição para honrar o fazer colaborativo. Analiso o meu pensar e o meu escrever em direção ao fazer narrativo, tanto em termos das pesquisas que desenvolvo e para além do pesquisar. Narro tensões vivenciadas, ao aprender a pensar e escrever narrativamente, e concluo que o processo é aberto, e o tornar-me pesquisadora está sempre em progresso.
Pengembangan Tanaman Anggrek di Kawasan Wisata Hutan Pinus Motilango Kecamatan Tibawa Kabupaten Gorontalo
Authors: Lalla Milawati , Sudiarta I Made 
Published: August 2022

Orchid is one type of ornamental flower plant that has many types spread throughout the world, including Indonesia. The original habitat of orchids is forests or areas that have high humidity, rich in organic matter. Reduction of forest area makes several types of orchids threatened with extinction so that efforts are needed for conservation and protection. Motilango pine forest tourism found several types of orchids, but the surrounding community did not know the prospect of orchid plants if they were developed properly. The purpose of the activity is to educate the local community and tourism managers to cultivate orchids to become a source of family income. The method used is discourse method and discussion. Participants consist of communities around the area, village officials and pine forest tourism managers. The material presented consisted of an introduction to the characteristics of orchids, prospects, methods of propagation and cultivation of orchids. The result of the activity is that there is an increase in participant knowledge about orchid plants. There are two types of orchids that are commonly found in the tourist area of Motilango pine, namely the dove orchid (Dendrobium crumenatum) and the ground orchid (Spathoglottis plicata) which are easily propagated by separating seedlings. Orchid growing media that is widely available in the area is coconut husk.
Comparison of plasma- and saliva-derived exosomal miRNA profiles reveals diagnostic potential in head and neck cancer
Authors: Hofmann Linda , Abou Kors Tsima , Ezić Jasmin , Niesler Beate , Röth Ralph , Ludwig Sonja , Laban Simon , Schuler Patrick J. , Hoffmann Thomas K. , Brunner Cornelia , Medyany Valentin , Theodoraki Marie-Nicole 
Published: August 2022

Background: Head and neck squamous cell carcinomas (HNSCC) lack tumor-specific biomarkers. Exosomes from HNSCC patients carry immunomodulatory molecules, and correlate with clinical parameters. We compared miRNA profiles of plasma- and saliva-derived exosomes to reveal liquid biomarker candidates for HNSCC.Methods: Exosomes were isolated by differential ultracentrifugation from corresponding plasma and saliva samples from 11 HNSCC patients and five healthy donors (HD). Exosomal miRNA profiles, as determined by nCounter® SPRINT technology, were analyzed regarding their diagnostic and prognostic potential, correlated to clinical data and integrated into network analysis.Results: 119 miRNAs overlapped between plasma- and saliva-derived exosomes of HNSCC patients, from which 29 tumor-exclusive miRNAs, associated with TP53, TGFB1, PRDM1, FOX O 1 and CDH1 signaling, were selected. By intra-correlation of tumor-exclusive miRNAs from plasma and saliva, top 10 miRNA candidates with the strongest correlation emerged as diagnostic panels to discriminate cancer and healthy as well as potentially prognostic panels for disease-free survival (DFS). Further, exosomal miRNAs were differentially represented in human papillomavirus (HPV) positive and negative as well as low and high stage disease.Conclusion: A plasma- and a saliva-derived panel of tumor-exclusive exosomal miRNAs hold great potential as liquid biopsy for discrimination between cancer and healthy as well as HPV status and disease stage. Exosomal miRNAs from both biofluids represent a promising tool for future biomarker studies, emphasizing the possibility to substitute plasma by less-invasive saliva collection.
Estimated pulse wave velocity can predict the incidence of new-onset atrial fibrillation: A 11-year prospective study in a Chinese population
Authors: Chen Haojia , Chen Guanzhi , Zhang Liling , Wu Weiqiang , Li Weijian , Wang Xianxuan , Yan Xiuzhu , Chen Youren , Wu Shouling 
Published: August 2022

BackgroundArterial stiffness, a risk factor for atrial fibrillation (AF), is rarely applied in clinical practice because of the difficulty and high cost of its measurement. Estimated pulse wave velocity (ePWV) is a simple, reproducible, and non-invasive index of arterial stiffness. This study was to assess the predictive value of ePWV for the risk of new-onset AF.MethodsSubjects were selected from the Kailuan cohort study population who underwent initial physical examination between 2006 and 2008. A total of 96,561 subjects were ultimately included in the final analysis. ePWV was divided into four groups according to quartiles. The Kaplan–Meier method was used to calculate the cumulative incidence of AF. A Cox regression model was used to assess the predictive value of estimated arterial stiffness for new-onset AF.ResultsMean age of subjects was 51.47 ± 9.68 years, while 76,968 (79.65%) were male and 19,663 (20.35%) were female. During mean follow-up period of 11.77 years, 1,215 AF events occurred. Results of the Kaplan–Meier analysis showed that the incidence of new-onset AF increased with increase in ePWV. Cox regression analysis showed that in the total population, the incidence of new-onset AF was 1.64, 1.90, and 2.64 times higher in the medium, medium-high, and high ePWV groups, respectively, compared with the low ePWV group. When stratified according to sex, ePWV had higher predictive value in the female population.ConclusionsIncreased ePWV increases the incidence of new-onset AF, and may promote application of more aggressive primary prevention.Trial registry nameRisk factors and intervention for cardiology, cerebrovascular and related disease (Kailuan Study); URL: http://www.chictr.org.cn/showproj.aspx?proj=8050; Registration number: ChiCTR-TNRC-11001489.
CYP2C19 loss-of-function alleles predicts clinical outcomes in East Asian patients with acute myocardial infarction undergoing percutaneous coronary intervention and stenting receiving clopidogrel
Authors: Chen Yu-Wei , Liao Yi-Ju , Chang Wei-Chun , Hsiao Tzu-Hung , Lin Ching-Heng , Hsu Chiann-Yi , Liu Tsun-Jui , Lee Wen-Lieng , Chen Yi-Ming 
Published: August 2022

BackgroundCYP2C19 loss-of-function (LOF) alleles reduce the effectiveness of clopidogrel and are associated with high rates of clinical events in patients undergoing percutaneous coronary intervention (PCI) and stenting in Northeast Asians. However, the prevalence and influence of CYP2C19 LOF alleles in Southeast Asians remain unclear.ObjectivesThis study aims to retrospectively investigate the prevalence of CYP2C19 LOF alleles and clinical outcomes in East Asian patients taking clopidogrel and undergoing PCI.MethodsBetween June 2019 and June 2020, volunteer participants in a single medical center were consecutively selected. The genetic data of CYP2C19 were derived from the Taiwan Precision Medicine Initiative (TPMI). Patients receiving clopidogrel while undergoing PCI with stenting were retrospectively analyzed.ResultsA total of 999 patients (62.4 ± 11.1 years old, 83.7% men) were enrolled; 39.3% without the CYP2C19 LOF allele (normal metabolizers + rapid metabolizers, NM + RM); 44.9% with one LOF allele (intermediate metabolizers, IM); 15.7% with two LOF alleles (poor metabolizers, PM). The incidence of stroke was higher in the PM subgroup compared to the NM + RM subgroup or IM subgroup in patients presenting with acute myocardial infarction (AMI). The 1-year major adverse cardiac and cerebrovascular events (MACCE)-free survival rates in all participants were similar among the three groups. However, in the AMI group, the 1-year MACCE-free survival rates were significantly lower in the PM subgroup compared to the NM + RM subgroup or IM subgroup.ConclusionIn East Asians presenting with AMI, CYP2C19 PM was associated with deleterious cardiovascular outcomes and stroke. Our results reinforce the crucial role of preemptive CYP2C19 genotyping in East Asian AMI patients receiving clopidogrel treatment.