bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of Pancreatic Lipase Inhibition in Fermented Beverages Brewed from Katuk Leaves Using RSM
Authors: Maryati Yati , Susilowati Agustine , Mulyani Hani , Aspiyanto  , Budiari Setyani 
Published: July 2022

The inhibition of pancreatic lipase and the associated reduction of lipid absorption has become the most appropriate approach for treating obesity. Meanwhile, katuk (Sauropus androgynus) leaves are rich in polyphenols that act as natural bioactive compounds and are also responsible for the potential effect on metabolic diseases, including inhibition of pancreatic lipase activity. Naturally occurring polyphenols can inhibit pancreatic lipase and consequently affect fat digestion as well as energy intake. Therefore, this study aimed to optimize the inhibitory activity of pancreatic lipase, which plays an essential role in lipid absorption. In fermented katuk (Sauropus androgynus) leaves were brewed following RSM using a Box Behnken design. Data analysis was used to optimize the formulation with a response surface model consisting of three factors namely sucrose concentration ranging from 10-20% b/v, culture 10-20 b/v, as well as fermentation time of 1-5 days. The parameters tested were the percentage inhibition of pancreatic lipase, antioxidant activity, polyphenol, and total acid. Based on the RSM optimization results obtained from the three influencing factors, the optimum conditions were established namely 10.43% w/v sucrose, 10% v/v kombucha culture, and fermentation for 5 days. These conditions yielded the most optimal responses, with the percentage inhibition of pancreatic lipase, antioxidant activity, polyphenol, and total acid being 86.13%, 96.27%, 0.97 mg GAE/mL, and 1.11%, respectively. In general, the results demons-trated that the RSM method of the Box Behnken design and the parameter prediction values obtained using the model equation are in good agreement with the experimental values with at least R2 ≥ 0.8.
The Effects of Processing Time on the Total Phenolic, Flavonoid Content, and Antioxidant Activity of Multi Bulb and Single Bulb Black Garlic
Authors: Krisnawan Alfian Hendra , Budiono Ryanto , Natarika Albina , Mirani Arum , Andarini Novia 
Published: July 2022

Black garlic is produced by processing multi-bulb garlic (Allium sativum) or single-bulb garlic in high temperature and high humidity for several days. Black garlic has many health benefits, such as an antioxidant activity resulting from its compound, including groups of flavonoid and phenolic compounds. This study aimed to analyze the effect of aging time on multi-bulb and single-bulb black garlic on the content of total phenolic, flavonoid, and antioxidant activity. Black garlic was processed at a 60-70°C heating temperature and 70-80% relative humidity for 25 days. Determination of total phenol and flavonoid contents was conducted using spectrophotometric methods with gallic acid as a standard of total phenolic and quercetin as a standard of flavonoid, while the antioxidant activity was determined by DPPH radical reduction. The results showed that total phenolic contents (% w/w GAE), flavonoids contents (% w/w QE), and EC50 values at 0 until day 25 increased on a particular day in multi-bulb and single-bulb black garlic. The optimal total phenolic content of both black garlic was obtained by heating for 20 days, flavonoid content of multi-bulb garlic for 10 days, and single-bulb black garlic for 15 days. Highest antioxidant activity was obtained on days 20 and 25 for single-bulb black garlic and multi-bulb black garlic, respectively. The aging time of black garlic affects total phenolic, flavonoid content, and antioxidant activity. In general, longer processing time caused an increase in the total phenolic content, flavonoid content, and antioxidant activity of both black garlics. Multi-bulb black garlic showed higher phenolic or flavonoid content and antioxidant activity than single-bulb black garlic.
The Effect of Relationship Marketing, Promotions, and Brand Image on Purchasing Decision of Sahira Dates Syrup
Authors: Simanjuntak Vera Clara , Kusumaningrum Dewi Ayu 
Published: July 2022

Aims: This study aimed to discover the effect of relationship marketing, promotions, and brand image on purchasing decision of Sahira Dates syrup.
Study Design: Quantitative study
Place and Duration of Study: Study location was in Bogor City, with a study duration of five months from August – December 2021.
Methodology: An associative study using a quantitative approach. The study population was Sahira Dates syrup customers. The samples were 137 respondents, determined using purposive sampling. Data were collected using interviews, questionnaire, and documents. The study utilized validity test, reliability test, descriptive statistical analysis, classic assumption test, multiple linear regression analysis, and hypothesis test with the SPSS Statistic 20 program.
Results: The study results showed that the total average of each variable was categorized as good. The relationship marketing sub-variable had a high average assessment, where employees of Sahira Dates syrup are fast and responsive in handling customer complaints. The promotion sub-variable had a high average assessment, where promotions in the form of rebates (IDR) and discounts (%) by Sahira Dates syrup can attract customers appeal to purchase. The brand image sub-variable had a high average assessment, where services offered by Sahira Dates syrup staff are positive. The purchasing decision sub-variable had a high average assessment, where the price as affordable by the public’s purchasing power. Partially, relationship marketing, promotion, and brand image variables positively and significantly affected purchasing decision. Meanwhile, simultaneously, relationship marketing, promotions, and brand image affected purchasing decision. The researcher suggests maintaining a better long-term relationship between the company and its customers by providing services about company information, product information, customer complaints, or consultations about herbal medicines through forums or other media communication in order to create good corporate and customer relationships and employees can better understand the character of each customer. Also improving marketing communication, including by doing promotions by giving discounts, buy 1 get 1, free shipping, and building with other products on social media such as Facebook (Meta), TikTok, Instagram, website, youtube, marketplace, and others.
Conclusion: Relationship marketing, promotions, and brand image had a partial, positive, and significant effect on purchasing decision. Meanwhile, simultaneously, relationship marketing, promotions, and brand image affected purchasing decision.
Modeling of resilience based on categorized recovery scenario and improving resilience with viscous damper
Authors: Akehashi Hiroki , Takewaki Izuru 
Published: July 2022

AbstractIn this study, a model for the evaluation of a building's resilience and recovery time is proposed, and a new method is developed for the optimal viscous damper placement for a targeted resilience. The features of this model are as follows: 1) building components are categorized into systems in view of their functionality, 2) recovery time is regarded as a function of the damage to building components and human resources for repairing the components, 3) the model is applicable to structural design. This design method uses a type of real‐coded genetic algorithm (GA). The effective use of a constraint on the sum of the added damper damping coefficients enables an efficient search for the solution.
Determination of a reliable assessment for occupational eye lens dose in nuclear medicine
Authors: Miyaji Noriaki , Miwa Kenta , Iimori Takashi , Wagatsuma Kei , Tsushima Hiroyuki , Yokotsuka Noriyo , Murata Taisuke , Kasahara Tetsuharu , Terauchi Takashi 
Published: July 2022

AbstractThe most recent statement published by the International Commission on Radiological Protection describes a reduction in the maximum allowable occupational eye lens dose from 150 to 20 mSv/year (averaged over 5‐year periods). Exposing the eye lens to radiation is a concern for nuclear medicine staff who handle radionuclide tracers with various levels of photon energy. This study aimed to define the optimal dosimeter and means of measuring the amount of exposure to which the eye lens is exposed during a routine nuclear medicine practice. A RANDO human phantom attached to Glass Badge and Luminess Badge for body or neck, DOSIRIS and VISION for eyes, and nanoDot for body, neck, and eyes was exposed to 99mTc, 123I, and 18F radionuclides. Sealed syringe sources of each radionuclide were positioned 30 cm from the abdomen of the phantom. Estimated exposure based on measurement conditions (i.e., air kerma rate constants, conversion coefficient, distance, activity, and exposure time) was compared measured dose equivalent of each dosimeter. Differences in body, neck, and eye lens dosimeters were statistically analyzed. The 10‐mm dose equivalent significantly differed between the Glass Badge and Luminess Badge for the neck, but these were almost equivalent at the body. The 0.07‐mm dose equivalent for the nanoDot dosimeters was greatly overestimated compared to the estimated exposure of 99mTc and 123I radionuclides. Measured dose equivalents of exposure significantly differed between the body and eye lens dosimeters with respect to 18F. Although accurately measuring radiation exposure to the eye lenses of nuclear medicine staff is conventionally monitored using dosimeters worn on the chest or abdomen, eye lens dosimeters that provide a 3‐mm dose equivalent near the eye would be a more reliable means of assessing radiation doses in the mixed radiation environment of nuclear medicine.
Neuropeptides in Cancer: Friend and Foe?
Authors: Wu Yue , Berisha Adrian , Borniger Jeremy C. 
Published: July 2022

AbstractNeuropeptides are small regulatory molecules found throughout the body, most notably in the nervous, cardiovascular, and gastrointestinal systems. They serve as neurotransmitters or hormones in the regulation of diverse physiological processes. Cancer cells escape normal growth control mechanisms by altering their expression of growth factors, receptors, or intracellular signals, and neuropeptides have recently been recognized as mitogens in cancer growth and development. Many neuropeptides and their receptors exist in multiple subtypes, coupling with different downstream signaling pathways and playing distinct roles in cancer progression. The consideration of neuropeptide/receptor systems as anticancer targets is already leading to new biological and diagnostic knowledge that has the potential to enhance the understanding and treatment of cancer. In this review, recent discoveries regarding neuropeptides in a wide range of cancers, emphasizing their mechanisms of action, signaling cascades, regulation, and therapeutic potential, are discussed. Current technologies used to manipulate and analyze neuropeptides/receptors are described. Applications of neuropeptide analogs and their receptor inhibitors in translational studies and radio‐oncology are rapidly increasing, and the possibility for their integration into therapeutic trials and clinical treatment appears promising.
Ultrathin Self‐Standing Covalent Organic Frameworks toward Highly‐Efficient Nanofluidic Osmotic Energy Generator
Authors: Wang Ce , Tang Jiadong , Li Leyuan , Wan Jiahe , Ma Yuchen , Jin Yuhong , Liu Jingbing , Wang Hao , Zhang Qianqian 
Published: July 2022

AbstractNanofluidics is promising in the construction of highly‐efficient osmotic energy generator, but it is still a challenge to develop large‐scale and high‐performance nanofluidic membranes. The emerging covalent organic frameworks (COFs) provide a desirable platform to create nanofluidic membranes with high ion selectivity and permeability towards effective osmotic energy conversion. Herein, an ultrathin self‐standing COF nanofluidic membranes based on terephthalaldehyde‐tetrakis(4‐aminophenyl)methane is developed to construct high‐efficiency nanofluidic osmotic energy generator. Benefiting from the nano‐confined channels (1.4 nm) and negative surface charges, the COF based nanofluidic membrane demonstrates both excellent cation selectivity and high ion conductance. Moreover, an ultrathin thickness of ≈1.5 µm significantly reduces the membrane resistance. Consequently, the nanofluidic osmotic energy generator based on COF membrane can deliver a high output power of 5.31 W m−2 under a 50‐fold salinity gradient simulating natural river/sea junction, which is superior to most reported systems and reaches the industrial level. More importantly, such a COF nanofluidic membrane exhibits excellent stability in response to various environmental factors, including wide saline solution concentration, temperature and pH ranges. This work is anticipated to highlight the great potential of 1D COF nanofluidic membranes toward highly‐efficient osmotic energy generators.
Trends in Layered Double Hydroxides‐Based Advanced Nanocomposites: Recent Progress and Latest Advancements
Authors: Chen Biao‐Qi , Xia Hong‐Ying , Mende Lokesh Kumar , Lee Chia‐Hung , Wang Shi‐Bin , Chen Ai‐Zheng , Xu Zhi‐Ping , Kankala Ranjith Kumar 
Published: July 2022

AbstractRecently, layered double hydroxides (LDHs) have gathered vast interest due to overall positive charge, unique crystallinity, and biocompatibility for diverse applications. Despite the advantageous attributes, these hydrotalcites often result in several limitations concerning the application requirements, such as aggregation, as well as poor chemical and thermal stabilities, hindering their scale‐up progress and practical utilization. In addressing these issues, the recent advancements in the fabrication of intelligent LDHs nanocomposites based on organically (polymer/polyelectrolyte)‐modified and inorganic (metal)‐composited architectures are systematically presented. Initially, a brief note on the shortcomings in various fields and the chemistry of these pristine LDHs is given. Then, various synthetic strategies used to fabricate these emerging LDH nanocomposites are comprehensively emphasized, focusing on the advancements in their structure and applicability. In addition, the effects of various attractive physicochemical attributes of LDHs and their nanocomposite forms are discussed, including their applicability in adsorption, biomedicine, catalysis, energy, and environment‐related applications. In summary, this article is concluded with an outlook concerning the positioning of LDH‐based nanocomposites compared to other innovative materials, as well as the current challenges and future requirements for scale‐up.
Highly Efficient Polarization‐Controlled Electrical Conductance Modulation in a van der Waals Ferroelectric/Semiconductor Heterostructure
Authors: Parker Jacob , Gu Yi 
Published: July 2022

AbstractUtilizing the unique in‐plane/out‐of‐plane polarization coupling in ferroelectric van der Waals α‐In2Se3, ferroelectric‐polarization‐controlled electrical conductance modulation in two‐dimensional (2D) MoS2 with a large dynamic range of over 5 orders of magnitude and excellent non‐volatility is demonstrated. This highly efficient control of the electrical conductance is facilitated by enhanced capacitive coupling through atomic‐layer‐deposition‐grown Al2O3 as the dielectric medium. By varying the in‐plane poling bias to the ferroelectric α‐In2Se3, the electrical conductance of vertically stacked 2D MoS2 can be tuned continuously. This approach enables simplified device design and provides great flexibility in device integrations, and it can be applied in principle to manipulate the electronic states in any 2D semiconductors for various applications such as transistors, tunneling devices, and reconfigurable electronics. The results also provide insight into the ferroelectric polarization screening by ambient chemical species, highlighting the need for surface passivation, and/or device encapsulations.
Epidemiological investigation and proteomic profiling of typical TCM syndrome in HIV/AIDS immunological nonresponders
Authors: Ji Shao‐Xiu , Zheng Yan‐Feng , Li Xia , Li Bai‐Xue , Zou Jia‐Xi , Wang Yi‐Ting , Xia Xin‐Yi , Chen Xin , Hu Qian‐Nan , Wan Ting‐Jun , Wen Li , Feng Quan‐Sheng 
Published: July 2022

AbstractHIV/AIDS pandemic remains the world's most severe public health challenge, especially for HIV/AIDS immunological nonresponders (HIV/AIDS‐INRs), who tend to have higher mortality. Due to the advantages in promoting patients' immune reconstitution, Traditional Chinese medicine (TCM) has become one of the mainstays of complementary treatments for HIV/AIDS‐INRs. Given that effective TCM treatments largely depend on precise syndrome differentiation, there is an increasing interest in exploring biological evidence for the classification of TCM syndromes in HIV/AIDS‐INRs. In our study, to identify the typical HIV/AIDS‐INRs syndrome, an epidemiological survey was first conducted in the Liangshan prefecture (China), a high HIV/AIDS prevalence region. The key TCM syndrome, Yang deficiency of spleen and kidney (YDSK), was evaluated by using a tandem mass tag combined with liquid chromatography–tandem mass spectrometry (TMT‐LC–MS/MS). A total of 62 differentially expressed proteins (DEPs) of YDSK syndrome compared with healthy people were screened out. Comparative bioinformatics analyses showed that DEPs in YDSK syndrome were mainly associated with response to wounding and acute inflammatory response in the biological process. The pathway annotation is mainly enriched in complement and coagulation cascades. Finally, the YDSK syndrome‐specific DEPs such as HP and S100A9 were verified by ELISA, and confirmed as potential biomarkers for YDSK syndrome. Our study may lay the biological and scientific basis for the specificity of TCM syndromes in HIV/AIDs‐INRs, and may provide more opportunities for the deep understanding of TCM syndromes and the developing more effective and stable TCM treatment for HIV/AIDS‐INRs.
Sensitivitätsbetrachtungen zur rückwärtigen Schädigung des Betons beim Durchbohren dünner Bauteile
Authors: Zeman Oliver , Stierschneider Elisabeth , Voit Klaus , Köttl Philipp , Bergmeister Konrad 
Published: July 2022

AbstractDieser Fachbeitrag befasst sich mit der rückwärtigen Schädigung des Betons beim Durchbohren von Betonuntergrund unterschiedlicher Dicke und Zusammensetzung. Insbesondere bei der nachträglichen Installation von Befestigungen in sehr dünnen Bauteilen kann es bei der Erstellung des Bohrlochs zum vollständigen Durchbohren des Befestigungsuntergrunds kommen. Anzutreffen sind solche geringen Bauteildicken in der Praxis beispielsweise bei Hohlkammerdecken oder dünnen Fassadenelementen. Die beim Durchbohren entstehende rückwärtige Schädigung des Betons meint damit den Ausbruch auf jener Seite, die dem Beginn des Bohrvorgangs entgegengewandt ist. Dies ist dann von Relevanz, wenn etwaige nachträgliche Befestigungen dadurch einen großen Anteil ihrer Einbindetiefe in den Betonuntergrund verlieren. In diesem Beitrag wird auf der Grundlage von insgesamt mehr als 400 erstellten Bohrlöchern die Ausprägung der rückwärtigen Schädigung des Betons in Abhängigkeit von den Parametern Bauteildicke, Bohrdurchmesser, Größtkorn, Bohrverfahren und Schlagenergie des Bohrgeräts untersucht. Auf Grundlage der Untersuchungen kann gezeigt werden, dass die Tiefen und die Volumina der Ausbrüche einer logarithmischen Normalverteilung folgen. Dadurch lässt sich die Größe der rückwärtigen Schädigung des Betons statistisch beschreiben und damit die verbleibende Verankerungstiefe berechnen.
No one is an island: The influence of social crowding on prosocial intentions
Authors: Tong Luqiong , He Fengyun 
Published: July 2022

AbstractCharitable activities emphasizing distant recipients or places often struggle to attract contributions because consumers tend to be more willing to help others who are spatially closer to them. Therefore, identifying methods to promote prosocial intentions toward distant recipients is critical, and the present study considers the implications of social crowding, as a common environmental factor, for evoking such prosocial intentions. Four studies conducted online and in the laboratory demonstrate that consumers are more likely to feel a stronger social connection to recipients of help in uncrowded (vs. crowded) environments, which, in turn, increases their helping intentions. This influence of social crowding on prosocial intentions is also moderated by spatial distance such that the effect is more significant when the charitable project targets distant (vs. closer) recipients.
Li2SiO3 Modification of C/LiFe0.5Mn0.5PO4 for High Performance Lithium‐Ion Batteries
Authors: Liu Xichang , Ouyang Baixue , Hao Rui , Liu Penggao , Fan Xiaowen , Zhang Mengjie , Pan Mengwei , Liu Weifang , Liu Kaiyu 
Published: July 2022

AbstractThe carbon‐coated LiFe0.5Mn0.5PO4 (C/LFMP) and carbon‐coated LiFe0.5Mn0.5PO4@Li2SiO3 (C/LFMP‐LSO) could be successfully prepared by high temperature solid‐state reaction. Even though the crystal structure and morphology of C/LiFe0.5Mn0.5PO4 was not changed by Li2SiO3 coating, Li2SiO3 modification was able to facilitate the diffusion of lithium ions, resulting in an excellent rate performance and cyclic stability of C/LFMP‐1LSO (1 wt %). The reversible discharge specific capacities of C/LFMP‐1LSO are 157.6 mAh g−1 and 106.3 mAh g−1 at 0.1C and 10C, respectively. Meanwhile, the C/LFMP‐1LSO was cycled for 500 times at 5C with a capacity retention rate of 85.3 %. Furthermore, at a low temperature of 6 °C and 0.2C, the C/LFMP‐1LSO displayed good low temperature performance with a discharge specific capacity of 140.6 mAh g−1. Li2SiO3 coating was considered an effective way to boost the overall electrochemical performance of C/LFMP.
Heavy Alkali Metal Manganate Complexes: Synthesis, Structures and Solvent‐Induced Dissociation Effects
Authors: Ballmann Gerd M. , Gentner Thomas X. , Kennedy Alan R. , Hevia Eva , Mulvey Robert E. 
Published: July 2022

AbstractRare examples of heavier alkali metal manganates [{(AM)Mn(CH2SiMe3)(N‘Ar)2}∞] (AM=K, Rb, or Cs) [N‘Ar=N(SiMe3)(Dipp), where Dipp=2,6‐iPr2‐C6H3] have been synthesised with the Rb and Cs examples crystallographically characterised. These heaviest manganates crystallise as polymeric zig‐zag chains propagated by AM⋅⋅⋅π‐arene interactions. Key to their preparation is to avoid Lewis base donor solvents. In contrast, using multidentate nitrogen donors encourages ligand scrambling leading to redistribution of these bimetallic manganate compounds into their corresponding homometallic species as witnessed for the complete Li ‐ Cs series. Adding to the few known crystallographically characterised unsolvated and solvated rubidium and caesium s‐block metal amides, six new derivatives ([{AM(N‘Ar)}∞], [{AM(N‘Ar)⋅TMEDA}∞], and [{AM(N‘Ar)⋅PMDETA}∞] where AM=Rb or Cs) have been structurally authenticated. Utilising monodentate diethyl ether as a donor, it was also possible to isolate and crystallographically characterise sodium manganate [(Et2O)2Na(nBu)Mn[(N‘Ar)2], a monomeric, dinuclear structure prevented from aggregating by two blocking ether ligands bound to sodium.
Positive Cooperativity Induced by Interstrand Interactions in Silver(I) Complexes with α,α′‐Diimine Ligands
Authors: Zare Davood , Piguet Claude , Prescimone Alessandro , Housecroft Catherine E. , Constable Edwin C. 
Published: July 2022

AbstractInvited for the cover of this issue are Davood Zare, Claude Piguet, Edwin C. Constable and co‐workers at the University of Basel and the University of Geneva. The image depicts a [AgIL]+ intermediate about to catch a second α,α′‐diimine ligand to form the stable [AgIL2]+. Read the full text of the article at 10.1002/chem.202200912.