bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors that distinguish opioid withdrawal during induction with buprenorphine microdosing: a configurational analysis
Authors: K. K. Adams , E. J. Miech , D. M. Sobieraj 
Published: October 2022

Abstract
Background
Novel buprenorphine dosing strategies have emerged with an aim to transition patients from opioid agonists to buprenorphine without prerequisite opioid withdrawal. We applied a configurational approach to a subset of data from our earlier systematic review to answer the following question: when patients received a buprenorphine initiation strategy aimed to eliminate prerequisite withdrawal, what factors consistently distinguished patients that experienced withdrawal during the initiation process from patients that did not?

Methods
From the 24 cases identified by our systematic review, we included cases that were treated using buprenorphine microdosing strategies (oral or transdermal), cases with opioid use disorder, and cases that fully transitioned to buprenorphine without continuing the full opioid agonist. Configurational analysis was used to identify combinations of patient and regimen level factors that uniquely distinguished cases experiencing withdrawal during induction.

Result
Fourteen cases were included in our analysis, of which 9 experienced opioid withdrawal symptoms. Three factors were involved in explaining both the presence and absence of withdrawal symptoms: history of heroin use, history of methadone use, and duration of overlap between buprenorphine and the full opioid agonist during induction. For the presence of withdrawal symptoms, the addition of a fourth factor “buprenorphine starting dose” resulted in a model with perfect consistency and coverage; for the absence of withdrawal symptoms, the addition of a fourth factor “induction duration” similarly resulted in a model with perfect consistency and 80% coverage.

Conclusion
Application of configurational methods allowed synthesis of case reports identified through a systematic review.
Determining factors for the creation of innovation-based ventures
Authors: Escorcia Adalberto , Ramos-Ruiz Jose , Zuluaga-Ortiz Rohemi , Delahoz-Domínguez Enrique 
Published: October 2022

AbstractThis research aims to determine the impact of internal and external factors of Social Capital, Entrepreneurial Self-Efficacy, and Person-Entrepreneurship Fit in the transition of nascent entrepreneurs toward venture creation. For the development of this research, a sample of 500 entrepreneurs located in Colombia who are creating a company was taken. The research methodology is hypothetical-deductive with a cross-sectional multiple causal correlation design with an explanatory scope and is divided into three stages: first, an exploratory analysis of the data relating to the study variables is carried out. Second, a principal component analysis is carried out. Finally, the third stage is the modelling using the Partial Least Squares-Path Modelling methodology. Among the most relevant findings, it is found that Social Capital is significant in explaining Person-Entrepreneurship Fit. In turn, Social Capital and Person-Entrepreneurship Fit are significant in explaining Entrepreneurial Self-Efficacy. Finally, the construct of Venture Creation is only significantly explained by Person-Entrepreneurship Fit. Consequently, it can be concluded that the influence of social and psychological variables within the business cycle is significant, and models and strategies must consider these elements to design tools that support the optimal development of start-ups within the business cycle, so that they consolidate as stable ventures. This study contributes to filling the research gap by focusing on the factors determining the entrepreneurial process beyond its initial phase.
In-vivo assessment of meniscal movement in the knee joint during internal and external rotation under load
Authors: Fuchs Andreas , Georgii Joachim , Taghizadeh Elham , Heldmann Stefan , Lange Thomas , Bendak Sebastian F. , Siegel Markus , Yilmaz Tayfun , Schmal Hagen , Izadpanah Kaywan 
Published: October 2022

Abstract
Purpose
The menisci transmit load between femur and tibia and thus play a crucial role in the functionality of the knee joint. Knee joint movements have a major impact on the position of the menisci. However, these meniscus movements have not yet been assessed in a validated setting. The objective of this study is to evaluate the meniscal movements in MRI with prospective motion correction based on optical tracking under loading via internal and external tibial torques.

Methods
Thirty-one healthy volunteers were recruited for this study. MRI scans were performed in internal and external rotation induced by a torque of 5 Nm, using a 3 T MRI. A validated software used the generated images to calculate the absolute meniscus movements as the sum of all vectors. Differences between subgroups were analyzed by using a Wilcoxon signed-rank test.

Results
The MM shows an average movement of 1.79 mm in anterior-lateral direction under internal rotation and 6.01 mm in posterior-lateral direction under external rotation, whereas the LM moves an average of 4.55 mm in posterior-medial direction under internal rotation and 3.58 mm in anterior-medial direction under external rotation. When comparing the overall meniscus movements between internal and external rotation, statistically significant differences were found for total vector length and the direction of meniscus movements for medial and lateral meniscus. The comparison between medial and lateral meniscus movements also showed statistically significant differences in all categories for internal and external rotation.

Conclusions
Overall, the MM and LM movements in internal and external rotation differ significantly in extent and direction, although MM and LM movements in opposite directions during internal and external rotation can be observed. In internal rotation, most meniscus movements were found in the IHLM. In external rotation, the IHMM showed the greatest mobility. Segment analysis of internal vs. external rotation showed less difference in LM movements than MM.

Level of evidence
Level II.
Evaluation of 3D apparel design spatial visualization training for cognitive function of older adults: cross-cultural comparisons
Authors: Chang Hyo Jung Julie , Min Seoha 
Published: October 2022

AbstractThis study examined how older adults of four different ethnic groups evaluate the spatial visualization training using 3D apparel design software. The model tested was derived from the Technology Acceptance Model (TAM) and a Unified Theory of Acceptance and Use of Technology (UTAUT). A quantitative research design with an online questionnaire using the purposive quota sampling was used. Structure equation modeling and ANOVAs were performed to test the hypotheses with 600 completed data. The result shows significant ethnic differences of the perceptions, attitude, and behavioral intention for our spatial visualization training. Especially, Asian Americans found the training easy to be involved with and were more likely to use it, whereas Caucasian Americans felt the training to be most difficult and were less likely to use it, compared to other ethnic groups. Also, perceived ease of use and the performance expectancy are cardinal in increasing the positive attitude toward the training. This study discovered the significant factors influencing the intention to use the apparel design virtual technology to improve cognitive functioning. The ethical differences found on the latent variables among four ethnic groups indicate the need of more thoughtful training development by considering the different cultural requirements and challenges.
The effect of loading time on marginal bone change of implants immediately placed after extraction: a retrospective study
Authors: Lee Sung-Jae , Kim Euy-Hyun , Lee Dong-Keon , Song In-Seok , Jun Sang-Ho 
Published: October 2022

Abstract
Background
The purpose of this study is to compare and analyze the treatment outcomes between two groups which are both immediately placed implant cases, one is immediate loading, and the other is conventional loading group.

Methods
Medical records of the patients who underwent implant treatment which were immediately placed after tooth extraction were analyzed. Demographic data were collected and by using periapical or panoramic radiographic image, marginal bone level and distant crestal bone level were measured. Marginal bone change over time was analyzed and compared between immediate loading group and conventional loading group.

Results
A total of 71 patients, 112 immediately placed implants after tooth extraction were initially involved. Measuring was done with implants which had not failed (81). 10 implants were had failed and removed. The others were excluded because of follow-up loss, absence of radiographic image, etc. Demographic data were collected, and measured values were averaged at each follow-up and showed in linear graphs.

Conclusions
In case of immediate implantation of dental implant after extraction, loading time could affect marginal bone level or biological width of the implant. Immediate loading group showed 0.92 mm (mean value) more bone loss compared to conventional loading group at bone–implant contact points 24 months after implantation. At distant crestal points, there was no noticeable difference in bone change pattern between two groups.
Chronic Viral Hepatitis in Elite Athletes: Approaches to Risk Assessment, Prevention and Management
Authors: Mak Lung-Yi , Beasley Ian , Kennedy Patrick T. F. 
Published: October 2022

AbstractElite athletes who participate in contact sports are at risk of bleeding injuries, leading to transmission of blood-borne viruses including hepatitis type B, C and D (HBV, HCV and HDV) capable of causing chronic liver disease, liver failure and liver cancer. In view of the significant advances in the viral hepatitis field over the past decade, more structured approaches should be in place to screen for and manage viral hepatitis in elite athletes. HBV status should be assessed in all elite athletes, and those infected should receive nucleos(t)ide analogues for viral suppression, while uninfected individuals should receive HBV vaccination. The all-oral direct acting antivirals for HCV are highly effective and safe, thus the remaining challenge with hepatitis C is case identification and linkage to care. HDV is only found in HBV-infected individuals, which is characterized by rapid disease progression and higher rates of cirrhosis and liver cancer in infected subjects. Pegylated interferon was the mainstay of treatment for HDV infection until bulevirtide, a viral entry inhibitor, was recently approved by the European Union (EMA) and FDA in America, while multiple novel therapies are already in clinical trials as part of the HBV cure program. Overall, awareness of chronic viral hepatitis in athletes should be improved. Prevention remains the cornerstone of the management of viral hepatitis in sport coupled with rigorous disease assessment in infected individuals, and antiviral therapy where indicated.
Long-term effects of caesarean delivery on health and behavioural outcomes of the mother and child in Bangladesh
Authors: Rahman Mostafizur , Khan Nuruzzaman , Rahman Aminur , Alam Mahmudul , Khan Alam 
Published: October 2022

Abstract
Background
Medically unnecessary caesarean section (CS) is now an ongoing concern worldwide including in Bangladesh. This intensifies the occurrence of adverse maternal and child health outcomes. We investigated the associations of CS with some basic health and behavioural outcomes of the mothers and their children in Bangladesh.

Methods
We conducted a community-based case–control study from May to August 2019. A total of 600 mother–child dyads were interviewed using a structured questionnaire, 300 of them had CS, and 300 had vaginal delivery (VD) in their most recent live births. The exposure variable was the mode of delivery, classified as 1 if mothers had CS and 0 if mothers had VD. The outcome variables were a group of health and behavioural problems of the mothers and their children. Multivariate or multiple logistic regression model, separately for each health and behavioural outcome, was used to determine the effect of exposure variable on outcome variable after adjusting for possible confounders.

Results
The mean age and weight of mothers were 25.1 years and 53.1 kg, respectively. Likelihoods of headache, after delivery hip pain, problem of daily activities, and breastfeeding problem were reported higher among mothers who had CS in their most recent live birth than mothers who had VD. Similarly, children who were born through the CS operation were more likely to report breathing problem, frequent illness, lower food demand and lower hours of sleeping.

Conclusion
The use of CS increases the risks of health and behavioural problems of the mothers and their children. Policies and programs to avoid medically unnecessary CS and increase awareness over its adverse effects are important.
Self-medication and Anti-malarial Drug Resistance in the Democratic Republic of the Congo (DRC): A silent threat
Authors: Akilimali Aymar , Bisimwa Charles , Aborode Abdullahi Tunde , Biamba Chrispin , Sironge Leonard , Balume Alain , Sayadi Rahma , Ajibade Samuel Babatunde , Akintayo Akintola Ashraf , Oluwadairo Tolulope Olamide , Fajemisin Emmanuel Adebowale 
Published: October 2022

Abstract
Background
Malaria is a global infectious (vector-borne: Anopheles mosquitoes) disease which is a leading cause of morbidity and mortality in Sub-Saharan Africa (SSA). Among all its parasitic (protozoan: Plasmodium sp.) variants, Plasmodium falciparum (PF) is the most virulent and responsible for above 90% of global malaria deaths hence making it a global public health threat.

Main context
Despite current front-line antimalarial treatments options especially allopathic medications and malaria prevention (and control) strategies especially governmental policies and community malaria intervention programs in SSA, PF infections remains prevalent due to increased antimicrobial/antimalarial drug resistance caused by several factors especially genetic mutations and auto(self)-medication practices in SSA. In this article, we focused on the Democratic Republic of Congo (DRC) as the largest SSA country by bringing perspective into the impact of self-medication and antimalarial drug resistance, and provided recommendation for long-term improvement and future analysis in malaria prevention and control in SSA.

Conclusions
Self-medication and anti-malarial drug resistance is a major challenge to malaria control in DRC and sub-Saharan Africa, and to achieve sustainable control, individual, community and governmental efforts must be aligned to stop self-medication, and strengthen the health systems against malaria.
Cardiac surgery receipt and outcomes for people using secondary mental healthcare services: Retrospective cohort study using a large mental healthcare database in South London
Authors: Brooks Gonul , Weerakkody Ruwan , Harris Matthew , Stewart Robert , Perera Gayan 
Published: October 2022

Abstract

Background
Patients diagnosed with mental health problems are more predisposed to cardiovascular disease, including cardiac surgery. Nevertheless, health outcomes after cardiac surgery for patients with mental health problems as a discrete group are unknown. This study examined the association between secondary care mental health service use and postoperative health outcomes following cardiac surgery.

Methods
We conducted a retrospective observational research, utilizing data from a large South London mental healthcare supplier linked to national hospitalization data. OPCS-4 codes were applied to classify cardiac surgery. Health results were compared between those individuals with a mental health disorder diagnosis from secondary care and other local residents, including the length of hospital stay (LOS), inpatient mortality, and 30-day emergency hospital readmission.

Results
Twelve thousand three hundred and eighty-four patients received cardiac surgery, including 1,481 with a mental disorder diagnosis. Patients with mental health diagnosis were at greater risk of emergency admissions for cardiac surgery (odds ratio [OR] 1.60; 1.43, 1.79), longer index LOS (incidence rate ratio 1.28; 1.26, 1.30), and at higher risk of 30-day emergency readmission (OR 1.53; 1.31, 1.78). Those who underwent pacemaker insertion and major open surgery had worse postoperative outcomes during index surgery hospital admission while those who had major endovascular surgery had worse health outcomes subsequent 30-day emergency hospital readmission.

Conclusion
People with a mental health disorder diagnosis undertaking cardiac surgery have significantly worse health outcomes. Personalized guidelines and policies to manage preoperative risk factors require consideration and evaluation.
Characteristic of Non–Sinus-Type Parasagittal Dural Arteriovenous Fistulas: Clinical and Cadaveric Experiences
Authors: Miyake Shigeta , Nakai Yasunobu , Suenaga Jun , Akimoto Taisuke , Uemura Kazuya , Funakoshi Kengo , Yamamoto Tetsuya 
Published: October 2022

BACKGROUND:
In parasagittal dural arteriovenous fistulas (DAVFs), the shunt point is on the falx cerebri and drains directly into the cortical vein. The venous structure anatomy of the falx cerebri is not well understood.

OBJECTIVE:
To describe a parasagittal DAVF as a non–sinus-type DAVF using clinical expertise and cadaver analysis. We focused on the clinical characteristics of parasagittal DAVFs, anatomy of the cortical vein directly flowing into the falx cerebri, and venous route in the falx cerebri.

METHODS:
Six patients with parasagittal DAVFs were examined between April 2009 and March 2019. In 7 cadaver heads, we examined the entire falx cerebri length and the cortical veins flowing into it were noted. The falx cerebri was divided down from the midline into the dura propria to examine the venous pattern.

RESULTS:
Clinically, all 6 cases were classified as parasagittal DAVFs. Intracerebral hemorrhage occurred in 2 patients (33.3%). In all 6 cases, only the cortical vein was the draining vein ipsilateral to the shunt point. One patient (16.7%) underwent transarterial embolization, 2 (33.3%) underwent direct surgery, and 2 (33.3%) underwent combined transarterial embolization with direct surgery. In the anatomic study, 7 (50.0%) venous structures directly flowed into the falx cerebri and 5 (35.7%) were located in the parasinus portion. The veins directly flowing into the falx ran through the dura propria on each side.

CONCLUSION:
Based on the clinical characteristics and anatomic features, clinicians must pay attention to cerebral hemorrhage in patients with parasagittal DAVFs to manage aggressive symptoms.
A new network for the synergistic translation of mouse research
Authors: Sansom Owen 
Published: October 2022

Over the past 20 years, the UK has become a leading force in the generation and use of complex mouse models in the precise investigation of human disease. Nevertheless, there remains a great challenge in improving how research in animals is translated to clinical benefits.
Developing and expanding connections between basic scientists and clinicians to ensure that animal models accurately recapitulate human disease will be key to this effort. This is the focus of the new UK Medical Research Council (MRC) National Mouse Genetics Network (https://nmgn.mrc.ukri.org/), which we believe will hugely impact our ability to harness recent advances in mouse genetics.
The National Mouse Genetics Network is a major £22 million investment initially comprising seven challenge-led research clusters with members distributed across the UK. At its core, the Mary Lyon Centre at MRC Harwell will act as a repository for, and provider of, genetically altered mice, as well as generate and share data, training, specialist facilities and resources. Importantly, each cluster will integrate expertise in fundamental biology with clinical findings to better address pertinent research questions.
Results from previous, smaller-scale, network initiatives suggest that this model can synergise research, but we believe that this structure will work better when carried out on a larger scale, with greater scope for collaboration and capacity of the system. This Editorial will outline the principal aims of the Network and identify the main areas in which this model will be able to exploit the power and synergy of its different elements.
Artificial intelligence-based model for COVID-19 prognosis incorporating chest radiographs and clinical data; a retrospective model development and validation study
Authors: Walston Shannon L , Matsumoto Toshimasa , Miki Yukio , Ueda Daiju 
Published: October 2022

Objectives: The purpose of this study was to develop an artificial intelligence-based model to prognosticate COVID-19 patients at admission by combining clinical data and chest radiographs. Methods: This retrospective study used the Stony Brook University COVID-19 dataset of 1384 inpatients. After exclusions, 1356 patients were randomly divided into training (1083) and test datasets (273). We implemented three artificial intelligence models, which classified mortality, ICU admission, or ventilation risk. Each model had three submodels with different inputs: clinical data, chest radiographs, and both. We showed the importance of the variables using SHapley Additive exPlanations (SHAP) values. Results: The mortality prediction model was best overall with area under the curve, sensitivity, specificity, and accuracy of 0.79 (0.72–0.86), 0.74 (0.68–0.79), 0.77 (0.61–0.88), and 0.74 (0.69–0.79) for the clinical data-based model; 0.77 (0.69–0.85), 0.67 (0.61–0.73), 0.81 (0.67–0.92), 0.70 (0.64–0.75) for the image-based model, and 0.86 (0.81–0.91), 0.76 (0.70–0.81), 0.77 (0.61–0.88), 0.76 (0.70–0.81) for the mixed model. The mixed model had the best performance (p value < 0.05). The radiographs ranked fourth for prognostication overall, and first of the inpatient tests assessed. Conclusions: These results suggest that prognosis models become more accurate if AI-derived chest radiograph features and clinical data are used together. Advances in knowledge: This AI model evaluates chest radiographs together with clinical data in order to classify patients as having high or low mortality risk. This work shows that chest radiographs taken at admission have significant COVID-19 prognostic information compared to clinical data other than age and sex.