bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultivating Clinical Judgment in Pharmacological Decision-Making Through Reflection on Practice
Authors: Davis Rebecca G. , Wood Felecia G. 
Published: March 2022

Background:
Competent clinical judgment about pharmacological therapies by nurses is essential for safe medication outcomes. This study examined the impact of postclinical pharmacology-focused reflective debriefing sessions on clinical judgment in prelicensure senior nursing students.

Method:
A nonrandomized repeated measures design was used to compare clinical judgment of students who participated in an additional learning activity with students who did not. Data were collected using Lasater's Clinical Judgment Rubric.

Results:

Within-groups analysis of variance demonstrated statistically significant increases in clinical judgment scores at mid- and late-semester timepoints for the entire cohort of participants (
n
= 128). However, analysis of covariance showed no statistically significant differences in the clinical judgment scores for the intervention (
n
= 62) and control (
n
= 66) groups.

Conclusion:

Clinical experiences provide opportunities for prelicensure students to develop clinical judgment about pharmacological therapies. Nurse educators must implement and evaluate strategies to foster this process.

[
J Nurs Educ
. 2022;61(3):143–146.]
Dual Collegiate Roles—The Lived Experience of Nursing Student Athletes
Authors: Engelke Eileen C. , Frederickson Keville 
Published: March 2022

Background:
Teamwork and communication, characteristics learned through playing college sports, can precipitate a sense of wonder in the lived experiences of nursing students who played a college sport.

Method:
A phenomenological study was conducted to understand the meaning of the collegiate roles of the nursing student and the student athlete. These roles carry different sets of responsibilities, social contacts, and physical and emotional demands. Thirteen practicing nurses who played a college sport during their nursing program were interviewed.

Results:
Data analysis revealed four essential themes that described the meaning of their experience: athletic identity, perseverance, advocates and adversaries, and belongingness. Results suggest participation in college sports creates a sense of belonging that assists in the transition into college.

Conclusion:

Although nursing students may be deterred from coordinating academics and athletics, this study indicates it is possible and may even have benefits, both academically and during students' transition into practice.

[
J Nurs Educ
. 2022;61(3):117–122.]
Ethics Education for Nurses: Foundations for an Integrated Curriculum
Authors: Robichaux Catherine , Grace Pamela , Bartlett Jennifer , Stokes Felicia , Saulo Lewis Mileva , Turner Martha 
Published: March 2022

Background:
Complexity in health care environments causes practice problems. Nurses bear responsibility for recognizing, addressing, and preventing ethical problems. Inadequacies in ethics education are partly to blame and contribute to nurse moral distress, attrition, and suboptimal care. Foundational curricula structures adequate for developing nurse moral agency are needed.

Method:
The state of the science of ethics education in nursing was explored in-depth by a subcommittee of the American Nurses Association Ethics Advisory Board. A framework based in nursing goals was designed by nurse ethics experts to address ethics education across levels of curricula and practice. Rest's four-component model of moral behavior structures guidelines.

Results:
The model captures three facets of nurse moral agency: necessary characteristics, knowledge and skills, and motivation. A case is provided to illustrate its utility.

Conclusion:

This framework provides the means to meet the profession's goal of preparing ethically competent nurses who will exercise moral agency.

[
J Nurs Educ
. 2022;61(3):123–130.]
Sex Influences Age-Related Changes in Natural Antibodies and CD5+ B-1 Cells
Authors: Webster Sarah E , Ryali Brinda , Clemente Michael J , Tsuji Naomi L , Holodick Nichol E 
Published: March 2022

Abstract
Natural Abs are primarily produced by B-1 cells and are essential for protection against Streptococcus pneumoniae. The incidence and mortality rate for pneumococcal infection increases dramatically after age 65, disproportionately affecting males in both human and murine systems. To date, there is a significant gap in our understanding of the relationship among sex, aging, natural IgM efficacy, and the natural IgM repertoire. Our investigation demonstrates that the protective capacity of serum IgM against pneumococcal infection is maintained in IgM obtained from aged female mice but absent in IgM from aged male mice. To understand this difference in protective capacity, we examined serum Ig, discovering that the protective change was not associated with shifts in levels of phosphorylcholine (PC)- or pneumococcal capsular polysaccharide serotype 3–specific IgM. Interestingly, we observed that aged females have an increase in the total number of CD5+ B-1 cells, higher serum IL-5 levels, and a larger percentage of aged female CD5+ B-1 cells that express CD86 as compared with aged males. Furthermore, single-cell IgM repertoire analysis from peritoneal PC+, splenic PC+, and bone marrow CD5+ B-1 cell subsets demonstrated greater diversity with age and a higher level of germline status in female mice than previously observed in studies of aged male mice. Aged female CD5+ B-1 cells also expressed higher levels of transcripts associated with cell activity and self-renewal, such as Nanog and Hmga2. Taken together, these data indicate that females maintain a more diverse and active CD5+ B-1 cell pool and natural IgM repertoire, which has implications for sex-related susceptibility to infection and disease.
Cannabinoid CB2receptors and spinal microglia are implicated in tingenone-mediated antinociception in mice
Authors: Moura Clarice C.V. , dos Santos Rafaela S. , Duarte Lucienir P. , Galdino Giovane 
Published: March 2022

Objective:
To investigate the antinociceptive effect of tingenone on inflammatory pain, as well as and the involvement of the cannabinoid receptors type 2 (CB2) and spinal microglia in this process.

Methods:
Male Swiss mice were subjected to inflammatory pain induced by intraplantar injection of carrageenan. The nociceptive threshold was measured by von Frey filaments test. Tingenone was administered orally 60 min before carrageenan injection. To evaluate the involvement of CB2 receptor, endocannabinoids, and microglia, AM630 (a CB2 receptor antagonist), MAFP (an inhibitor of an enzyme that hydrolyses endocannabinoids), and minocycline (a microglial inhibitor) were given intrathecally 20 min before tingenone administration. In addition, an immunofluorescence assay was used to evaluate CB2 receptor and CD11B (a microglial marker) expression in the spinal cord dorsal horn.

Results:
Tingenone significantly reduced carrageenan-induced hyperalgesia, which was reversed by pretreatment with AM630. MAFP and minocycline potentiated and prolonged the tingenone- induced antinociception. CD11B expression was increased in the spinal cord dorsal horn of mice with inflammatory pain pretreated with tingenone, which was reduced by AM630, MAFP, and minocycline.

Conclusions:
CB2 receptors and endocannabinoids participate in the tingenone-induced antinociception which may involve the inhibition of microglia at spinal level.
Morin attenuates L-arginine induced acute pancreatitis in rats by downregulating myeloperoxidase and lipid peroxidation
Authors: Rehman Kanwal , Rashid Ummara , Jabeen Komal , Akash Muhammad Sajid Hamid 
Published: March 2022

Objective:
To explore the therapeutic role of morin against L-arginine-induced acute pancreatitis in rats.

Methods:
The group 1 received two intraperitoneal injections of normal saline, and groups 2-4 were given two intraperitoneal injections of L-arginine (250 mg/100 g body weight) at 1 h interval to induce acute pancreatitis. Subsequently, group 2 received no further treatment while groups 3 and 4 were treated with morin (30 mg/kg) and diclofenac sodium (30 mg/kg), respectively. Blood glucose and serum levels of insulin, α-amylase, malondialdehyde, myeloperoxidase, alanine aminotransferase, aspartate aminotransferase and cholesterol were measured. Moreover, histopathological study was carried out to investigate the effect of morin treatment on physiology of the pancreas.

Results:

L-arginine significantly altered the level of blood glucose and serum levels of insulin, α-amylase, malondialdehyde, myeloperoxidase, alanine aminotransferase, aspartate aminotransferase and cholesterol. Treatment with morin or diclofenac sodium significantly improved the levels of these biomarkers. Furthermore, morin showed more significant effect than diclofenac sodium. Histopathological analysis verified that morin protected the pancreas from deleterious effects of L-arginine.

Conclusions:
Morin plays a protective role against L-arginine- induced acute pancreatitis via reducing lipid peroxidation and tissue inflammation, and attenuating acute pancreatitis-associated alteration in insulin secretion and glucose metabolism.
Natural compounds as potential inhibitors of SARS-CoV-2 main protease
Authors: Mishra Amaresh , Pathak Yamini , Kumar Anuj , Mishra Surabhi Kirti , Tripathi Vishwas 
Published: March 2022

Objective:
To explore natural compounds as potential inhibitors against main protease (Mpro) of SARS-CoV-2.

Methods:
In the current study, systematic molecular docking analysis was conducted using AutoDock 4.2 to determine the binding affinities and interactions between natural compounds and Mpro. Selected natural compounds were further validated using a combination of molecular dynamic (MD) simulations and molecular mechanic Poisson-Boltzmann surface area (MM/PBSA) free energy calculations.

Results:
Out of twenty natural compounds, four natural metabolites namely, amentoflavone, guggulsterone, puerarin, and piperine were found to have strong interaction with Mpro of SARS-CoV-2 based on docking analysis. During MD simulations, all four natural compounds bound to Mpro at 50 ns and MM/G/P/BSA free energy calculations showed that all four shortlisted ligands had stable and favorable energies with strong binding to Mpro protein.

Conclusions:
Guggulsterone is a potential inhibitor of COVID- 19 main protease Mpro. Further in vitro and pre-clinical studies are needed.
Bounds for the distribution of the Frobenius traces associated to products of non-CM elliptic curves
Authors: Cojocaru Alina Carmen , Wang Tian 
Published: March 2022

AbstractLet
$g \geq 1$
be an integer and let
$A/\mathbb Q$
be an abelian variety that is isogenous over
$\mathbb Q$
to a product of g elliptic curves defined over
$\mathbb Q$
, pairwise non-isogenous over
$\overline {\mathbb Q}$
and each without complex multiplication. For an integer t and a positive real number x, denote by
$\pi _A(x, t)$
the number of primes
$p \leq x$
, of good reduction for A, for which the Frobenius trace
$a_{1, p}(A)$
associated to the reduction of A modulo p equals t. Assuming the Generalized Riemann Hypothesis for Dedekind zeta functions, we prove that
$\pi _A(x, 0) \ll _A x^{1 - \frac {1}{3 g+1 }}/(\operatorname {log} x)^{1 - \frac {2}{3 g+1}}$
and
$\pi _A(x, t) \ll _A x^{1 - \frac {1}{3 g + 2}}/(\operatorname {log} x)^{1 - \frac {2}{3 g + 2}}$
if
$t \neq 0$
. These bounds largely improve upon recent ones obtained for
$g = 2$
by Chen, Jones, and Serban, and may be viewed as generalizations to arbitrary g of the bounds obtained for
$g=1$
by Murty, Murty, and Saradha, combined with a refinement in the power of
$\operatorname {log} x$
by Zywina. Under the assumptions stated above, we also prove the existence of a density one set of primes p satisfying
$|a_{1, p}(A)|>p^{\frac {1}{3 g + 1} - \varepsilon }$
for any fixed
$\varepsilon>0$
.
On a topological Ramsey theorem
Authors: Kubiś Wiesław , Szeptycki Paul 
Published: March 2022

AbstractWe introduce natural strengthenings of sequential compactness, the r-Ramsey property for each natural number
$r\geq 1$
. We prove that metrizable compact spaces are r-Ramsey for all r and give examples of compact spaces that are r-Ramsey but not
$(r+1)$
-Ramsey for each
$r\geq 1$
(assuming Continuum Hypothesis (CH) for all
$r>1$
). Productivity of the r-Ramsey property is considered.
PENINGKATAN KAPASITAS KELEMBAGAAN DESA TANGGAP BENCANA
Authors: Hilman Yusuf Adam , Khoirurrosyidin Khoirurrosyidin , Nasution Robby Darwis 
Published: March 2022

Praktik pemberdayaan yang dilakukan berangkat dari kondisi kelembagaan pemerintahan desa, yang masih mencari formula yang tepat dalam rangka memperkuat kapasitasnya dalam membangun sistem penanggulangan bencana di level pemerintah desa, supaya dapat memunculkan bentuk kelembagaan desa tangga bencana yang tepat. Penguatan kelembagaan desa tanggap bencana berusaha mengujikan permodelan dengan memperkuat kelembagaan desa, melalui beberapa tahapan, diantaranya: 1). Komunikasi dengan pemerintah desa 2). FGD dan musyawarah Permodelan desa tanggap bencana, 3). Rekomendasi hasil FGD dan Musyawarah. Pemerintah desa melihat bahwa kelembagaan desa tanggap bencana dirasakan sangat di perlukan, beberapa hal telah disepakati, terkait pembentukan kelembagaan Tangguh bencana, persoalan anggaran, dna juga partisipasi masyarakat, yang harus dilanjutkan dalam tahap selanjutnya
Pengentasan Kemiskinan Melalui Social Preneur Bagi Ibu-Ibu PKK
Authors: Maliki Budi Ilham , Nashrudin Achmad 
Published: March 2022

Kegiatan ini hendak membantu dalam upaya pengentasan kemiskinan melalui pendekatan pemberdayaan dan gender, yakni pemberdayaan ibu-ibu PKK dengan menumbuh kembangkan social preneur pada organisasi dan kegiatan PKK. Kegiatan ini akan memberikan pelatihan ketrampilan sesuai peminatan mitra, agar mitra mampu menghasilkan produk unggulan yang memiliki nilai ekonomis dan dibutuhkan pasar. Produk tersebut selain untuk dipasarkan juga untuk dikonsumsi sendiri, dan mengurangi beban pengeluaran mitra dalam membiayai konsumsi rumah tangga. Untuk menumbuhkembangkan social preneur, yang bertujuan sosial (pengentasan kemiskinan), diberikan pula pelatihan motivasi kewirausahaan dan ketrampilan manajerial kewirausahaan, yang mencakup manajemen produksi, manajemen keuangan, akuntansi sederhana dan manajemen pemasaran. Luara kegiatan ini adalah: 1) Pengurangan beban biaya konsumsi barang kebutuhan rumah tangga pada keluarga ibu-ibu PKK mitra,(2) Terbentuknya social preneur Ibu-Ibu PKK RW mitra yang mampu memberikan penghasilan tambahan kepada keluarga anggota PKK, dan 3) Terciptanya produk barang kebutuhan rumah tangga dan konveksi hasil produksi PKK mitra yang layak dipasarkan
Impacto de los ecosistemas de innovación social en la gestión universitária
Authors: Hidalgo Verónica Ochoa , Mero Cindy Loor , Andrade Fredy Morquecho , González Angela Duque 
Published: March 2022

La presente investigación devela la importancia de la generación de ecosistemas de innovación social en las Instituciones de Educación Superior (IES), lugar en donde se fomenta y desarrolla proyectos con soluciones innovadores, que fortalecen a la matriz productiva de dichos países. El objetivo del artículo es exponer los casos de estudio en las Universidades de la ciudad de Guayaquil como la Universidad Laica VICENTE ROCAFUERTE (ULVR) y Universidad Internacional del Ecuador (UIDE); el estudio en la ULVR, se desarrolló en su Incubadora de negocios, con los emprendimientos de estudiantes que buscan mejorar su calidad de vida; mientras que en la UIDE se expone el trabajo realizado por los tutores de titulación en donde se busca la relación de la carrera de Ingeniería Mecánica Automotriz con la innovación y emprendimiento social, y se garantiza el desarrollo del emprendimiento acompañado de su tutor y se generan soluciones innovadoras para los casos de estudio. La metodología aplicada tiene un enfoque cualitativo, descriptivo y documental, permitiendo fortalecer las habilidades y competencias en la gestión concluyendo que las IES fomentan los ecosistemas de innovación social a través de la formación de destrezas empresariales en los estudiantes, generar plazas de empleos y potenciar el crecimiento económico.
Application of Centrality Measures in Determining Regional Development Priorities in the Graph Representation of Kalimantan Island
Authors: Suyudi Mochamad , Adli Fajrul Iqbal , Supriatna Asep Kuswandi 
Published: March 2022

The relocation of the capital of the Republic of Indonesia to the Kalimantan raises new problems in regional development. In this paper the priority areas to be developed on the Kalimantan will be determined using Centrality Measures. The type of centrality measures used are degree centrality, leverage centrality, closseneess centrality, Jordan centrality, and betwenness centrality. The results show that Banjar, Ketapang, Sintang, KutaiÂ Kertanegara, and Murung Raya areas are the areas that are central to the island of Kalimantan. Although the center of the island of Kalimantan, it is necessary to study the results of this paper with the actual distance of each region.
La Red Feminista Quintanarroense y la toma pacífica del Congreso del Estado de Quintana Roo
Authors: Rodríguez Pedraza Yunitzilim , Cornelio Ramos Erika Lizbeth , Cortés González Sandra María Guadalupe 
Published: March 2022

La toma pacífica del Congreso del Estado de Quintana Roo es un hecho histórico. Mujeres organizadas articuladas bajo la Red Feminista Quintanarroense levantaron la voz y pusieron el cuerpo durante 95 días en plena pandemia por el virus COVID-19 —46 de ellos sin energía eléctrica ni suministro de agua— para exigir que se legislara sobre su derecho a decidir. Las autoridades, demostrando su poca formación en materia de perspectiva de género, derechos humanos y, específicamente, en lo que implica el derecho a la protesta pacífica, incentivaron el discurso de odio e intolerancia que de por sí ya existía en contra de las feministas, especialmente en contra de aquéllas que se posicionaban abiertamente a favor del aborto legal, seguro y gratuito.
No obstante, el movimiento cobró fuerza y logró que se designara una sede alterna para que la “Legislatura de la Paridad” sesionara y que se modificara el calendario establecido para la discusión de las iniciativas existentes respecto a la despenalización del aborto; también logró un dictamen positivo sobre la materia y evidenció claramente que el discurso político sobre la lucha para erradicar la violencia contra la mujer en el estado y en el país es una simulación.
A produção científica sobre mediação da informação em arquivos: uma análise bibliométrica
Authors: Farias Dayane Dos Santos , Santos Thais Helen Do Nascimento 
Published: March 2022

A mediação da informação tem sido amplamente discutida na Ciência da Informação, sobretudo no ambiente das bibliotecas. Em contrapartida, as reflexões no âmbito dos arquivos carecem de maior aprofundamento. Nesse contexto, este estudo analisa a produção científica sobre mediação da informação em arquivos indexada na base de dados BRAPCI, no período de 2010 a 2020. Objetiva identificar os artigos, autores, ano de publicação, autores mais citados e vinculação institucional dos mesmos. A metodologia utilizada pauta-se na bibliometria, bem como a utilização das técnicas de análise de citação. Os resultados da pesquisa revelam que apesar do crescimento das discussões sobre mediação da informação nos últimos anos, ainda há uma escassez de publicações que abordem a mediação em arquivos de forma mais efetiva, ou seja, há a necessidade de maiores reflexões e aprofundamento sobre a temática em questão.
A publicidade dirigida a menores e os novos limites em velhos hábitos no direito à alimentação
Authors: Fialho d’ Almeida Rita Guimarães 
Published: March 2022

Our work aims to reflect on the reasons that guide the enshrining of the rules related to advertising directed to minors, with particular emphasis on the most recent restrictions on advertising directed to minors under 16 years related to foodstuffs and beverages that contain high energy value, content of salt, sugar, saturated fatty acids and processed fatty acids.	Despite the progress related to the protection of children and young people, other problems persist and/or are aggravated, demanding a serious debate, resulting in urgent responses. Among such problems, obesity, often as a result of childhood, is a chronic and complex disease, with an increasing prevalence worldwide and considered by the World Health Organization as the global epidemic of the 21st century, while, on the other side of the balance, malnutrition appears as the main cause of death of children in some countries, especially on the African continent.	The reasons that guided our interest and choice in the approach of the present theme are precisely due to the realization of such realities that are so different from one another: on the one hand, the epidemic of childhood obesity, often leading to bullying, namely developed in a school context, a phenomenon that comprises multiple realities and variants of intimidation, aggression and harassment, of a physical or psychological nature and that, essentially, is characterized by the repetition of acts performed by one or more aggressors against another member of the same school community who, for various reasons, such as childhood obesity, it is in a situation of greater fragility; on the other hand, the disturbing malnutrition of thousands of children.	The discussion around such realities, with food as a common denominator, cannot ordinarily neglect the concept of sustainable consumption, which is also of capital importance and which marks the current political, economic and social discourses.	If there were any doubts as to its importance, the Universal Declaration of Human Rights expressly enshrined the human right to food in the context of the right to an adequate standard of living. Its effectiveness is conditio sine qua non of health’s promotion and protection, as well as human dignity, the fight against poverty and social exclusion and, in correspondence, the construction of more just and democratic societies.	We believe that, also in this area, the action of the States is essential. Democratization and fair access are necessary to guarantee the well-being of citizens. In this context, the enshrining of rules related to advertising directed to minors, although relevant, seems to be insufficient in the realization of the human right to food.