bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of digital implant impressions in clinical studies: A systematic review
Authors: Schmidt Alexander , Wöstmann Bernd , Schlenz Maximiliane Amelie 
Published: May 2022

AbstractObjectivesThe use of intraoral scanners (IOSs) for digital implant impressions in daily clinical practice is increasing. However, no structured literature review on the accuracy of digital implant impressions in clinical studies has been described to date. Therefore, this systematic review aimed to answer the PICO question: Which accuracy is described for digital implant impressions in clinical studies?Material and MethodsAn electronic database search was conducted in December 2021 using MeSH terms and free‐text search. English‐language studies addressing the accuracy of digital implant impressions in clinical studies involving at least 10 patients were included. All clinical indications were considered.ResultsEight publications between 2014 and 2021 matched the review criteria. However, the study designs showed considerable differences. The number of implants within the studies ranged from 1 to 6, and the number of patients ranged from 10 to 39. The oldest study (2014) revealed the highest deviation for linear distances at 1000 ± 650 µm, whereas the other studies reported data in the range of 360 ± 46 µm to 40 ± 20 µm. In one study, no numerical data were reported and all studies compared digital and conventional implant impressions.ConclusionsThe number of clinical studies on the accuracy of digital implant impressions is low. Thus, the impact of different factors, such as the scanpath or scanbody, could not be identified. However, the accuracy of recent IOSs for digital implant impressions in patients was shown to be clinically acceptable. Nevertheless, the transfer error still needs to be considered when fabricating implant‐supported restorations.
Inclusivity via ontological accountability
Authors: Moon Katie , Pérez‐Hämmerle Katharina‐Victoria 
Published: May 2022

AbstractConservation and environmental policies are increasingly criticized for marginalizing peoples, entities and practices. Typically overlooked, yet critical in their potential for marginalization and exclusion, are the assumptions that underlie a policy's classifications, categorizations and descriptions of reality. These ontological assumptions come to define which interventions are appropriate, or even possible, and for whom. We seek to illuminate the importance of ontology to policy‐making and implementation processes. We do so via an ontological analysis of selected elements of an international policy, the Convention on Biological Diversity, to show how language, logic, rights and responsibilities expressed and inferred within the policy could marginalize different entities and practices. The analysis demonstrates how a policy represents reality and thereby intervenes in the world, with consequences for alternative ontologies, peoples, and knowledges. To support ontological accountability, we offer a three‐stage conceptual framework to: deconstruct the language used in describing reality; make sense of how language and logic entangle rights and responsibilities; and enable transformation by becoming accountable to diverse practices of reality. Enabling the coexistence and practice of multiple ontologies is not easy or simple, but it is fundamental for transforming to inclusive policy‐making, implementation, and self‐determination.
Persistent advanced periductal fibrosis is associated with cagA‐positive Helicobacter pylori infection in post‐praziquantel treatment of opisthorchiasis
Authors: Phung Hang Thi Thu , Deenonpoe Raksawan , Suttiprapa Sutas , Mairiang Eimorn , Edwards Steven W. , Sripa Banchob 
Published: May 2022

AbstractBackgroundLiver fluke infection caused by Opisthorchis viverrini is associated with several hepatobiliary diseases including advanced periductal fibrosis (APF) and cholangiocarcinoma. Recently, we demonstrated a persistent APF in over one‐third of opisthorchiasis patients after worm removal by praziquantel (PZQ) treatment. However, the underlying mechanism(s) of this phenomena is unclear. Given a co‐infection with Helicobacter pylori (H. pylori) especially cagA‐positive strain enhances APF, we hypothesized that H. pylori with CagA virulent factor contributes to persistent APF.Materials and methodsSeventy‐five opisthorchiasis patients who underwent ultrasonography and treatment with PZQ were recruited in the 2‐year follow‐up study. Helicobacter and its cagA in the feces were examined by conventional and qPCR. Correlations between prevalence or bacterial loads of Helicobacter spp., H. pylori, and cagA‐positive H. pylori before and after PZQ treatment were analyzed among resolved, slowly resolved, relapsed, and persistent APF groups.ResultsOverall, prevalence of Helicobacter spp., H. pylori, and cagA‐positive H. pylori declined after PZQ treatment. However, only the prevalence and bacterial loads of cagA‐positive H. pylori detected at 2‐year post‐treatment were significantly lower than those before treatment (p < .05). In addition, both prevalence and bacterial loads of cagA‐positive H. pylori were significantly lower in the resolved APF group after PZQ treatment, while there were no significant changes in the slowly resolved, relapsed, and persistent APF groups. Among the APF subgroups, cagA‐positive H. pylori prevalence in both relapsed and persistent APF groups were significantly higher than the resolved APF group.ConclusionThe results support our hypothesis that H. pylori, especially cagA‐positive strain, contributes to the relapsed and persistent APF. A supplementary antibiotic treatment for H. pylori to reduce persistent APF and eventually CCA is warranted.
Probiotics mitigate Helicobacter pylori‐induced gastric inflammation and premalignant lesions in INS‐GAS mice with the modulation of gastrointestinal microbiota
Authors: He Cong , Peng Chao , Xu Xinbo , Li Nianshuang , Ouyang Yaobin , Zhu Yin , Lu Nonghua 
Published: May 2022

AbstractBackgroundDysbiosis of gastric microbiota including Helicobacter pylori (H. pylori) infection is associated with the development of stomach cancer. Probiotics have been shown to attenuate H. pylori‐induced gastritis, although their role in cancer prevention remains unclear. Thus, we aimed to explore the effects of probiotics on H. pylori‐induced carcinogenesis and the alterations of gastrointestinal microbiota.MethodsMale INS‐GAS mice were randomly allocated to H. pylori‐infected and non‐infected groups. After 4 weeks, probiotic combination (containing Lactobacillus salivarius and Lactobacillus rhamnosus) was administered in drinking water for 12 weeks. Stomachs were collected for RNA‐Sequencing and the differentially expressed genes were validated using RT profiler PCR array. 16S rRNA gene sequencing was performed to assess the alterations of gastrointestinal microbiota.ResultsProbiotics significantly alleviate H. pylori‐induced gastric pathology, including reduced infiltration of inflammation and lower incidence of precancerous lesions. RNA‐Sequencing results showed that probiotics treatment decreased expressions of genes involved in pro‐inflammatory pathways, such as NF‐κB, IL‐17, and TNF signaling pathway. Of note, probiotics did not suppress the growth of H. pylori, but dramatically reshaped the structure of both gastric and gut microbiota. The microbial diversity was increased in H. pylori‐infected group after probiotics treatment. While gastric cancer‐associated genera Lactobacillus and Staphylococcus were enriched in the stomach of H. pylori‐infected group, the beneficial short‐chain fatty acids‐producing bacteria, including Bacteroides, Alloprevotella, and Oscellibacter, were more abundant in mice treated with probiotics. Additionally, probiotics restored the H. pylori‐induced reduction of anti‐inflammatory bacterium Faecalibaculum in the gut.ConclusionsProbiotics therapy can protect against H. pylori‐associated carcinogenesis probably through remodeling gastrointestinal microbiota, which in turn prevent host cells from malignant transformation.
PUTTING CLIO BACK IN CLIOMETRICS
Authors: GAUTHIER LAURENT 
Published: May 2022

ABSTRACTThis article makes the argument for renewed cliometrics that could serve history. Over the past century, history and economics have grown relying on each other, but an imbalance has appeared, as the space between history and economics has been occupied by the latter. Consequently, historians have tended to shun these fields of inquiry. I begin my analysis with a discussion of the complex set of separate domains that lie between history and economics, and I determine certain salient features that define them—in particular, the search for nomothetic explanations. I examine the reception of economic method by historians and point out that it has suffered both from this nomothetic angle and from the implicit presumption that economics is only applicable to the economy. Stressing the distinction between understanding and explaining in the philosophy of history, I show that, for historians, explaining should remain in the realm of history. I then propose that economics be considered a methodological auxiliary for understanding, a form of new cliometrics, which does not attempt to offer explanations. I also discuss some examples of using microeconomics as a critical methodology in the study of ancient Greece.
Pretreatment processes assisted subcritical water hydrolysis for valorisation of spent coffee grounds
Authors: Park Jin‐Seok , Nkurunziza David , Roy Vikash Chandra , Ho Truc Cong , Kim Sung‐Yeoul , Lee Seung‐Chan , Chun Byung‐Soo 
Published: May 2022

SummaryThis study investigated the effect of sequential extraction techniques and pretreatment methods in enhancing the recovery of high‐value products from spent coffee ground. Supercritical carbon dioxide (SC‐CO2) deoiling was performed to recover non‐polar lipids, and subcritical water (SCW) hydrolysis of deoiled spent coffee ground (SCG) was conducted involving pretreatment with ultrasound (US‐SCG), and sample particle size reduction (PS‐SCG). SCW temperature, solid/liquid mixing ratio, constant pressure and residence time were studied for their effect on extracting reducing sugars (RS), total phenolic content (TPC), total flavonoid content (TFC), 5‐HMF, and furfural. Temperature increase enhanced hydrolysis efficiency and promoted RS dehydration into 5‐HMF and furfural. At 180 °C and 40 mg/600 mL, TPC, TFC and RS values increased significantly with ultrasound pretreatment correlating with improved antioxidant activities by DPPH and ABTS assays. Highest amount of 5‐HMF and furfural was obtained at 210°C (highest temperature studied) with 44.71 and 2.36 mg/100 g. Chlorogenic acid recovery was the highest in the non‐deoiled SCG (15.07 mg/100 g), with no significant difference observed in PS‐SCG, suggesting an increase due to its reduced particle size. The results of this study provide comprehensive knowledge on the combined effects of integrated engineering systems to boost the valorisation of SCGs into high‐value products.
Thermal inactivation kinetics parameters of browning enzymes in starfruit (Averrhoa carambola L.) juice
Authors: Tan Hui‐Ling , Koh Pei‐Nee , Mat Easa Azhar , Tan Thuan‐Chew 
Published: May 2022

SummaryThis study aimed to evaluate the thermal inactivation kinetics of polyphenol oxidase (PPO) and peroxidase (POD) in starfruit juice. It followed the Malaysia Food Regulations 1985 and CODEX STAN 247‐2005. Glucose, fructose and sucrose were the main sugars in starfruit juice. The total soluble solids, pH, titratable acidity, and total phenolics content of the starfruit juice produced were 8.13 ± 0.25 °Brix, 3.80 ± 0.05, 0.43% ± 0.02% malic acid, and 93.67 ± 4.96 mg GAEL−1, respectively. Thermal inactivation kinetics of PPO and POD followed the first‐order kinetic model. The decimal reduction time at 83.6 °C (D83.6) of PPO and POD was 198.48 and 98.4 s, respectively, while the thermal resistance constant (z value) of PPO and POD was 12.8 and 5.4 °C, respectively. In conclusion, PPO might be a suitable signal for thermal processing on starfruit juice since it has higher heat resistance than POD.
Why we need bricoleurs to foster robust governance solutions in turbulent times
Authors: Carstensen Martin B. , Sørensen Eva , Torfing Jacob 
Published: May 2022

AbstractThe public sector frequently confronts a heightened societal turbulence triggered by an increasing number of unpredictable and disruptive economic, political, and environmental crises. How can the public sector respond to this challenge? This article argues, first, that to continue to provide relevant solutions, public governance must be robust in the sense of adapting and innovating policies, programs, and services in ways that facilitate the achievement of basic public ambitions, functions, and values in the face of challenges, stressors, and threats. Second, to build robust governance, public managers must engage in bricolage and become bricoleurs in order to flexibly combine elements from competing and co‐existent public governance paradigms. Doing so necessitates the construction of institutions conducive to bricolage, that is, institutions that are characterized by a high degree of flexibility that allows for experimentation; institutions that foster inclusive deliberation, knowledge sharing and joint learning; and institutions that balance centralization with distributed agency.
How the Wake Up Safe pediatric anesthesia collaborative increased quality improvement capability and collaboration
Authors: Buck David W. , Claure Rebecca , Tjia Imelda M. , Varughese Anna M. , Brustowicz Robert , Subramanyam Rajeev 
Published: May 2022

AbstractWake Up Safe is a patient safety organization consisting of 40 institutions with a mission to improve the processes of care and outcomes for newborns, infants, and children having anesthesia for surgery and medical procedures. It was recognized that the level of quality improvement (QI), knowledge, and experience varied greatly between member institutions. In Fiscal Year 2015, the group's leadership created a subcommittee on QI and education in efforts to provide member institutions with the skills and resources to use QI methodology to improve care at their own institution. This subcommittee developed a program to improve members' knowledge in safety analytics and QI science and to help members implement change in their own institutions. This review describes the development and implementation of this initiative. As a result of this initiative, significant progress was made improving the QI capability of the collaborative over a two‐year period. This educational and support program included workshops, an online discussion forum, site visits, and project presentations.
Does a combination of self‐reported signs related to central sensitization and pressure pain threshold allow for a more detailed classification of pain‐related characteristics in patients with chronic musculoskeletal pain?: A cross‐sectional study
Authors: Mibu Akira , Nishigami Tomohiko , Tanaka Katsuyoshi , Yono Satoko , Manfuku Masahiro , Imai Ryota 
Published: May 2022

AbstractObjectivesThe clinical utility of combining the central sensitization (CS) inventory (CSI) with the pressure pain threshold (PPT) in assessing the effect of central sensitization on pain is unknown. This study aimed to investigate the effects of CSI, PPT, and their interaction on pain and the characteristics of clinical symptoms in patients with chronic musculoskeletal pain grouped according to the CSI score and PPT value.MethodA total of 187 participants with chronic musculoskeletal pain were recruited. PPT, brief pain inventory, widespread pain index, pain catastrophizing scale, EuroQol‐5 dimension, and CSI were assessed. Multiple regression analyses were performed using pain intensity and interference scores as dependent variables and the CSI score and PPT value as independent variables. Hierarchical cluster analysis was also performed to classify the participants into subgroups according to the CSI score and PPT value. Following the classification, pain‐related characteristics and health‐related QOL were compared among the subgroups.ResultsMultiple regression analyses demonstrated that only the CSI score significantly affected pain intensity and interference. As a result of the cluster analysis, three groups were identified: cluster 1 (n = 61, CSI low/PPT low group), cluster 2 (n = 78, CSI low/PPT high group), and cluster 3 (n = 48, CSI high/PPT low group). The CSI high/PPT low group had a higher incidence of pain‐related symptoms than the CSI low group regardless of the PPT value.ConclusionsCombined CSI and PPT may not fully allow a detailed classification of pain‐related characteristics. The CSI may be clinically more useful for assessing the effect of CS on pain‐related symptoms.
Potentiation of soybean resistance against Phakopsora pachyrhizi infection using phosphite combined with free amino acids
Authors: Picanço Bárbara B. M. , Silva Bruno N. , Rodrigues Fabrício A. 
Published: May 2022

AbstractConsidering the importance of Asian soybean rust (ASR), caused by Phakopsora pachyrhizi, in the decrease in soybean yield, this study investigated the potential of using phosphite combined with l‐α‐free amino acids (referred to as induced resistance [IR] stimulus hereafter) to boost defence responses of soybean plants against P. pachyrhizi infection. Plants were sprayed with water (control), acibenzolar‐S‐methyl (ASM) or IR stimulus and noninoculated or inoculated with P. pachyrhizi. Urediniospore germination was not affected by the IR stimulus in vitro. Reduced ASR severity, lower malondialdehyde concentration and less colonization of leaf tissues by P. pachyrhizi (lower TEF‐1α expression from 1 to 15 days after inoculation [dai]) occurred for IR stimulus‐sprayed plants. The pattern of gene expression for IR stimulus‐sprayed and infected plants was strikingly similar but sometimes more remarkable than that in ASM‐sprayed and infected plants. Higher production of phenolics and lignin along with stronger up‐regulation of PAL1.3 (5 and 10 dai), PAL2.2 (3 dai), PAL3.1 (1, 3 and 5 dai), ICS1 (5 dai), CHIA1 (1, 5 and 10 dai), CHI1B1 (5 dai), PR‐1A (5 and 10 dai), NR1‐2 (5 and 10 dai) and INR‐2 (5 and 10 dai) for IR stimulus‐sprayed plants increased their resistance against ASR. In addition, IR stimulus‐sprayed and infected plants showed less impairment of the photosynthetic apparatus and maintained high concentrations of chlorophyll a + b and carotenoids. These findings highlight the potential of using this IR stimulus for developing a well‐tuned and effective defensive strategy in soybean plants against P. pachyrhizi infection.
Circa 1.50–1.45 Ga metasedimentary rocks in southwestern Laurentia provide distinctive records of Mesoproterozoic regional orogenesis and craton interactions
Authors: Jones III James V. , Daniel Christopher G. 
Published: May 2022

ABSTRACTThe discovery of multiple deformed and metamorphosed sedimentary successions in southwestern Laurentia that have depositional ages between ca. 1.50 and 1.45 Ga marked a turning point in our understanding of the Mesoproterozoic tectonic evolution of the continent and its interactions with formerly adjacent cratons. Detrital zircon U-Pb ages from metasedimentary strata and igneous U-Pb zircon ages from interbedded metavolcanic rocks in Arizona and New Mexico provide unequivocal evidence for ca. 1.50–1.45 Ga deposition and burial, followed by ca. 1.45 and younger deformation, metamorphism, and plutonism. These events reflect regional shortening and crustal thickening that are most consistent with convergent to collisional orogenesis—the Mesoproterozoic Picuris orogeny—in southwestern Laurentia. Similar metasedimentary successions documented in the midcontinent of the United States and in eastern Canada help to establish ca. 1.45 Ga orogenesis as a continent-scale phenomenon associated with a complex and evolving convergent margin along southern Laurentia. Metasedimentary successions of similar age are also exposed across ~5000 km of the western Laurentian margin and contain distinctive 1.6–1.5 Ga detrital zircon populations that are globally rare except in select cratonic provinces in Australia and Antarctica. The recognition of these distinctive detrital zircon ages provides a transient record of plate interactions prior to breakup of Nuna or Columbia ca. 1.45 Ga and provides key constraints on global plate reconstructions.
Multiple phyla, one time resolution? Similar time averaging in benthic foraminifera, mollusk, echinoid, crustacean, and otolith fossil assemblages
Authors: Nawrot Rafał , Berensmeier Michaela , Gallmetzer Ivo , Haselmair Alexandra , Tomašových Adam , Zuschin Martin 
Published: May 2022

Abstract
Time averaging of fossil assemblages determines temporal precision of paleoecological and geochronological inferences. Taxonomic differences in intrinsic skeletal durability are expected to produce temporal mismatch between co-occurring species, but the importance of this effect is difficult to assess due to lack of direct estimates of time averaging for many higher taxa. Moreover, burial below the taphonomic active zone and early diagenetic processes may alleviate taxonomic differences in disintegration rates in subsurface sediments. We compared time averaging across five phyla of major carbonate producers co-occurring in a sediment core from the northern Adriatic Sea shelf. We dated individual bivalve shells, foraminiferal tests, tests and isolated plates of irregular and regular echinoids, crab claws, and fish otoliths. In spite of different skeletal architecture, mineralogy, and life habit, all taxa showed very similar time averaging varying from ~1800 to ~3600 yr (interquartile age ranges). Thus, remains of echinoids and crustaceans—two groups with multi-elemental skeletons assumed to have low preservation potential—can still undergo extensive age mixing comparable to that of the co-occurring mollusk shells. The median ages of taxa differed by as much as ~3700 yr, reflecting species-specific timing of seafloor colonization during the Holocene transgression. Our results are congruent with sequestration models invoking taphonomic processes that minimize durability differences among taxa. These processes together with temporal variability in skeletal production can overrule the effects of durability in determining temporal resolution of multi-taxic fossil assemblages.