bluuebunny/crossref_metadata_2025_split huggingface dataset:
CSF tap test in idiopathic normal pressure hydrocephalus: still a necessary prognostic test?
Authors: Griffa Alessandra , Bommarito Giulia , Assal Frédéric , Preti Maria Giulia , Goldstein Rachel , Armand Stéphane , Herrmann François R. , Van De Ville Dimitri , Allali Gilles 
Published: May 2022

Abstract
Objective
To assess whether gait, neuropsychological, and multimodal MRI parameters predict short-term symptom reversal after cerebrospinal fluid (CSF) tap test in idiopathic normal pressure hydrocephalus (iNPH).

Methods
Thirty patients (79.3 ± 5.9 years, 12 women) with a diagnosis of probable iNPH and 46 healthy controls (74.7 ± 5.4 years, 35 women) underwent comprehensive neuropsychological, quantitative gait, and multimodal MRI assessments of brain morphology, periventricular white-matter microstructure, cortical and subcortical blood perfusion, default mode network function, and white-matter lesion load. Responders were defined as an improvement of at least 10% in walking speed or timed up and go test 24 h after tap test. Univariate and multivariable tap test outcome prediction models were evaluated with logistic regression and linear support vector machine classification.

Results
Sixteen patients (53%) respondedpositively to tap test. None of the gait, neuropsychological, or neuroimaging parameters considered separately predicted outcome. A multivariable classifier achieved modest out-of-sample outcome prediction accuracy of 70% (p = .028); gait parameters, white-matter lesion load and periventricular microstructure were the main contributors.

Conclusions
Our negative findings show that short-term symptom reversal after tap test cannot be predicted from single gait, neuropsychological, or MRI parameters, thus supporting the use of tap test as prognostic procedure. However, multivariable approaches integrating non-invasive multimodal data are informative of outcome and may be included in patient-screening procedures. Their value in predicting shunting outcome should be further explored, particularly in relation to gait and white-matter parameters.
Measurement of upper limb function in ALS: a structured review of current methods and future directions
Authors: Hayden C. D. , Murphy B. P. , Hardiman O. , Murray D. 
Published: May 2022

AbstractMeasurement of upper limb function is critical for tracking clinical severity in amyotrophic lateral sclerosis (ALS). The Amyotrophic Lateral Sclerosis Rating Scale-revised (ALSFRS-r) is the primary outcome measure utilised in clinical trials and research in ALS. This scale is limited by floor and ceiling effects within subscales, such that clinically meaningful changes for subjects are often missed, impacting upon the evaluation of new drugs and treatments. Technology has the potential to provide sensitive, objective outcome measurement. This paper is a structured review of current methods and future trends in the measurement of upper limb function with a particular focus on ALS. Technologies that have the potential to radically change the upper limb measurement field and explore the limitations of current technological sensors and solutions in terms of costs and user suitability are discussed. The field is expanding but there remains an unmet need for simple, sensitive and clinically meaningful tests of upper limb function in ALS along with identifying consensus on the direction technology must take to meet this need.
Creatine kinase and prognosis in amyotrophic lateral sclerosis: a literature review and multi-centre cohort analysis
Authors: Gao Jiali , Dharmadasa Thanuja , Malaspina Andrea , Shaw Pamela J. , Talbot Kevin , Turner Martin R. , Thompson Alexander G. 
Published: May 2022

Abstract
Background
Amyotrophic lateral sclerosis (ALS) is a prognostically heterogeneous neurodegenerative disease. Blood creatine kinase (CK) level has been inconsistently reported as a prognostic biomarker and raised levels in some ALS patients have been presumed to reflect muscle wasting, which is also variable.

Methods
MEDLINE was systematically searched for papers related to CK in ALS and the relevant studies were reviewed. Using data from 222 ALS patients in a multi-centre, prospective, longitudinal cohort, survival analyses using Kaplan–Meier and Cox proportional hazards models were undertaken in relation to CK and other prognostic factors.

Results
Twenty-five studies investigating CK in ALS were identified, of which 10 specifically studied the link between CK and survival. Five studies observed no association, four found that higher CK levels were associated with longer survival and one, the opposite. In our cohort (n = 222), 39% of patients had a CK level above the laboratory reference range. Levels were higher in males compared to females (p < 0.001), in patients with limb versus bulbar onset of symptoms (p < 0.001) and in patients with higher lower motor neuron burden (p < 0.001). There was no significant trend in longitudinal CK values. Although a higher standardised log (CK) at first visit was associated with longer survival in univariate analysis (hazard ratio 0.75, p = 0.003), there was no significant association after adjusting for other prognostic covariates.

Conclusion
While raised CK levels in ALS do reflect lower motor neuron denervation to a large extent, they are not independently associated with survival when measured in the symptomatic phase of the disease.
Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours
Authors: Cleven Arjen H. G. , Schreuder Willem H. , Groen Eline , de Lange Jan , Briaire-de Bruijn Inge H. , Bovée Judith V. M. G. 
Published: May 2022

Abstract
Non-ossifying fibroma (NOF) and central giant cell granuloma (CGCG) are both benign tumours of bone with overlapping morphology and similar mutations in the RAS/MAPK pathway. However, NOF is located in the long bones with regression after puberty in contrast to CGCG which is located in the jaw bones and does not regress spontaneously. We hypothesised that endocrine regulation by oestrogen plays a role in the spontaneous regression in NOF. Therefore, we examined the expression of ERα in a series of NOF and CGCG. ERα expression (EP1) was determined using immunohistochemistry on 16 NOFs (whole slides), and 47 CGCGs (tissue microarrays (TMA’s n = 41 and whole slide n = 6)). As comparison, we included TMAs of other giant cell containing bone lesions: giant cell tumour of bone (n = 75), chondroblastoma (n = 12), chondromyxoid fibroma (n = 12), aneurysmal bone cyst (n = 6) and telangiectatic osteosarcoma (n = 6). All 16 NOF samples demonstrated ERα protein expression, while all 47 CGCG and all other giant cell containing bone tumours were negative. Most NOF samples had moderate staining intensity and between 24 and 49% of the spindle cells were ERα-positive. Our findings further support the role of endocrine regulation via oestrogen in the spontaneous regression in NOF. Whether oestrogen signalling at puberty is involved in the induction of senescence in the neoplastic cells of NOF harbouring RAS/MAPK pathway mutations needs further research. Since ERα expression was not observed in other giant cell containing bone lesions with overlapping morphological features, positive ERα expression may favour the diagnosis of NOF in challenging diagnostic cases.
Genetic testing enables a precision medicine approach for nephrolithiasis and nephrocalcinosis in pediatrics: a single-center cohort
Authors: Huang Lin , Qi Chang , Zhu Gaohong , Ding Juanjuan , Yuan Li , Sun Jie , He Xuelian , Wang Xiaowen 
Published: May 2022

Abstract
Objective
Hereditary factors are the main cause of pediatric nephrolithiasis (NL)/nephrocalcinosis (NC). We summarized the genotype–phenotype correlation of hereditary NL/NC in our center, to evaluate the role of genetic testing in early diagnosis.

Methods
The clinical data of 32 NL/NC cases, which were suspected to have an inherited basis, were retrospectively analyzed from May 2017 to August 2020. The trio-whole exome sequencing was used as the main approach for genetic testing, variants were confirmed by Sanger sequencing, and pathogenicity analysis according to protein function was predicted with custom-developed software.

Results
Causative monogenic mutations were detected in 24 of 32 NL/NC patients, and copy number variation was detected in one patient. A summary of manifestations in patients with inherited diseases revealed a significant degree of growth retardation, increased urinary excretion of the low-molecular weight protein, hypercalciuria, electrolyte imbalances, and young age of onset to be common in heredity disease. In addition, some patients had abnormal renal function (3 ppm 25). The most frequent pathology identified was distal renal tubular acidosis (with inclusion of SLC4A1, ATP6V1B1, and ATP6VOA4 genes), followed by Dent disease (CLCN5 and OCRL1 genes), primary hyperoxaluria (PH) (AGXT and HOGA1 genes) and Kabuki syndrome (KMT2D gene), which was more likely to present as NC or recurrent stone and having a higher correlation with a specific biochemical phenotype and extrarenal phenotype.

Conclusion
The etiology of NL/NC is heterogeneous. This study explored in depth the relationship between phenotype and genotype in 32 patients, and confirmed that genetic testing and clinical phenotype evaluation enable the precision medicine approach to treating patients.
Fuzzy forward dynamics of distinct gait phases with a prosthetic foot
Authors: Scheiterer Eduard S. , Leyendecker Sigrid 
Published: May 2022

AbstractThis work considers epistemic uncertainty in the form of fuzzy parameters in a multibody forward dynamics simulation of the human leg with a prosthetic foot. The thigh and shank are modelled as rigid bodies while the prosthetic foot, modelled after a carbon spring prosthesis, is represented by a predeformed geometrically exact beam model. A variational integrator is used to solve the equations of motion in the forward dynamics simulation and the Graph Follower algorithm is used to include epistemic uncertainty. Two cases are considered. Large movements are examined using a pendulum swing, similar to the swing phase during human gait. To validate the deformation of the prosthesis, a second case is examined, where the prosthesis is fixed in space and deforms under the weight of the body segments. Both cases consider a fuzzy Young’s modulus and determine the envelopes of the resulting uncertain target output. The Graph Follower algorithm was modified to substantially increase computational efficiency, enabling the propagation of fuzzy uncertainty through the complex multibody model with rigid and flexible bodies.
Localisation of the petrous internal carotid artery relative to the vidian canal on computed tomography: a case–control study evaluating the impact of petroclival chondrosarcoma
Authors: Connor Steve E. J. , Thomas Nicholas W. M. , Shapey Jonathan 
Published: May 2022

Abstract
Background
The vidian canal (VC) is normally a reliable anatomical landmark for locating the petrous internal carotid artery (pICA). This study determined the influence of petroclival chondrosarcoma on the relationship between the VC and pICA.

Methods
Nine patients (3 males, 6 females; median age 49) with petroclival chondrosarcoma, and depiction of the pICA on contrast-enhanced CT, were retrospectively studied. CT-based measurements were performed by two observers, both in the presence of the petroclival chondrosarcoma (case) and on the contralateral control side. The antero-posterior (AP) and craniocaudal (CC) measurements from the posterior VC to the pICA, whether the pICA was in the trajectory of the VC, and the coronal relationship of the pICA anterior genu with the VC were recorded.

Results
Chondrosarcoma usually displaced the pICA anteriorly (8/9 cases) and superiorly (6/9 cases) relative to the normal side with mean AP and CC measurements of 3.9 mm v 7.2 mm (p = 0.054) and 4.4 mm v 1.4 mm (p = 0.061). The VC trajectory less frequently intersected the pICA cross-section in the presence of chondrosarcoma however it was in the line of the eroded dorsal VC in one case. The anterior genu of the pICA was displaced more laterally by chondrosarcoma but usually remained superior to the VC.

Conclusion
Petroclival chondrosarcoma variably influences the anatomical relationship between the VC and the pICA, hence requiring an individualised approach. The pICA is usually anterosuperiorly displaced, and the anterior genu remains superior to the VC, however it may be located in the line of the canal.
Melt polymer drawn single and multi-capillary fibre-based electroosmotic pumps
Authors: Wu Liang , Farajikhah Syamak , Beirne Stephen , Large Maryanne C. J. , Fleming Simon , Innis Peter C. 
Published: May 2022

AbstractMicrofluidic devices have been employed in micro-analytical systems and microelectronics using inexpensive, customisable fluid-handling automation at the microliter scale. Here we utilise a well-established fibre drawing technique, which offers a range of materials and capillary conformations, that can be utilized within microfluidic devices to control fluid movement via electroosmotic processes to produce a simple electroosmotic pump (EOP). Single capillary EOPs were fabricated from drawn PU capillary fibres with internal diameters ranging from 73 to 200 µm and were shown to be capable of actively transporting a buffer solution using an external driving electric potential. A maximum flow rate of 0.8 ± 0.1 μL/min was achieved for a 73 ± 2 µm diameter PU capillary fibre at an applied potential of 750 V/cm. This flow rate was successfully increased up to 5.3 ± 0.3 μL/min by drawing a multi-capillary array consisting of 4, 5 and 7 capillaries.
The age and well-being “paradox”: a longitudinal and multidimensional reconsideration
Authors: Hansen Thomas , Blekesaune Morten 
Published: May 2022

AbstractThis paper explores qualifications to the much-discussed paradox that although aging is associated with multiple physical and social losses, subjective well-being (SWB) is stable or increasing in later life. We explore age-related changes in cognitive, affective, and eudaimonic dimensions in three waves of data spanning up to 15 years from the Norwegian NorLAG study (N = 4,944, age 40 − 95). We employ fixed-effect models to examine the nature and predictors of aging effects on SWB. Results indicate a general pattern of stability well into older age, but negative changes in advanced age across well-being measures. Declines in SWB are less pronounced and with a later onset for the cognitive compared with the other measures. Loss of health, a partner, and friends are robust predictors of declining SWB. Women report both more negative affect and engagement than men, and these differences increase with age. In conclusion, while increasing SWB from midlife to the mid-70 s attests to the adaptive behaviors and coping resources of young-old adults, the significant downturns in SWB in advanced age point to limits to psychological adjustment when health-related and social threats and constraints intensify.
Investigating the measurement of academic resilience in Aotearoa New Zealand using international large-scale assessment data
Authors: Rudd Georgia , Meissel Kane , Meyer Frauke 
Published: May 2022

AbstractAcademic resilience captures academic success despite adversity and thus is an important concept for promoting equity within education. However, our understanding of how and why rates of academic resilience differ between contexts is currently limited by variation in the ways that the construct has been operationalised in quantitative research. Similarly, comparing the strength of protective factors that promote academic resilience is hindered by differing approaches to the measurement of academic resilience. This methodological variation has complicated attempts to reconcile disparate findings about academic resilience. The current study applied six commonly used operationalisations of academic resilience that combined different thresholds of high risk and high achievement, to three international large-scale assessments, to explore how these different operationalisations impacted the findings produced. The context of Aotearoa New Zealand was chosen as a case study to further academic resilience research within this context and investigate how academic resilience manifests in an education system with relatively high levels of average achievement alongside low levels of educational equity. Within international large-scale assessment datasets, prevalence rates differed markedly across subject areas, grade levels, and collection cycles, as a function of the measure of academic resilience employed, while the strength of protective factors was more consistent. Thresholds that were norm-referenced produced more consistent findings across the different datasets compared to thresholds that were criterion-referenced. High levels of missing data prevented the analysis of some datasets, and differences in the way that key constructs were measured undermined the comparability of findings across international large-scale assessments. The findings emphasise the strengths and limitations of utilising international large-scale assessment data for the study of academic resilience, particularly within the Aotearoa New Zealand context. Furthermore, the study highlights that researchers’ methodological decisions have important impacts on the conclusions drawn about academic resilience.
Assessing expected utility and profitability to support decision-making for disease control strategies in ornamental heather production
Authors: Ruett Marius , Dalhaus Tobias , Whitney Cory , Luedeling Eike 
Published: May 2022

AbstractMany farmers hesitate to adopt new management strategies with actual or perceived risks and uncertainties. Especially in ornamental plant production, farmers often stick to current production strategies to avoid the risk of economically harmful plant losses, even though they may recognize the need to optimize farm management. This work focused on the economically important and little-researched production system of ornamental heather (Calluna vulgaris) to help farmers find appropriate measures to sustainably improve resource use, plant quality, and profitability despite existing risks. Probabilistic cost-benefit analysis was applied to simulate alternative disease monitoring strategies. The outcomes for more intensive visual monitoring, as well as sensor-based monitoring using hyperspectral imaging were simulated. Based on the results of the probabilistic cost-benefit analysis, the expected utility of the alternative strategies was assessed as a function of the farmer’s level of risk aversion. The analysis of expected utility indicated that heather production is generally risky. Concerning the alternative strategies, more intensive visual monitoring provides the highest utility for farmers for almost all levels of risk aversion compared to all other strategies. Results of the probabilistic cost-benefit analysis indicated that more intensive visual monitoring increases net benefits in 68% of the simulated cases. The application of sensor-based monitoring leads to negative economic outcomes in 85% of the simulated cases. This research approach is widely applicable to predict the impacts of new management strategies in precision agriculture. The methodology can be used to provide farmers in other data-scarce production systems with concrete recommendations that account for uncertainties and risks.
Usefulness of maximum intensity projection images of non-enhanced CT for detection of hyperdense middle cerebral artery sign in acute thromboembolic ischemic stroke
Authors: Oguro Sota , Mugikura Shunji , Ota Hideki , Bito Seiji , Asami Yuta , Sotome Wataru , Ito Yoshiaki , Kaneko Hideki , Suzuki Kazuyo , Higuchi Nobuya , Takase Kei 
Published: May 2022

Abstract
Purpose
To compare the sensitivity of the hyperdense middle cerebral artery (MCA) sign between maximum intensity projection (MIP) and conventional averaged images in patients with acute focal neurological deficits with acute thromboembolic MCA occlusion (MCA occlusion group) and patients with acute focal neurological deficits without MCA occlusion (control group).

Materials and methods
Initial computed tomography (CT) scans on admission were reconstructed with 5 mm thickness at every 3 mm interval for averaged and MIP images from 1 mm thickness non-contrast axial source images. Images were obtained from 30 cases each in the MCA occlusion and control groups. The CT values in the region of interests (ROIs) on the affected and unaffected sides of the MCA were compared. To compare CT values among subjects, the CT values were normalized by obtaining a ratio on the affected and unaffected sides, and the normalized CT values were analyzed using the receiver operating characteristic (ROC) curve.

Results
The hyperdense MCA sign was visually detected on MIP images in 90% cases and on 5 mm averaged images in only 57% cases in the MCA occlusion group. Based on the ROC analysis of the normalized ratio on the affected and unaffected sides, area under the curve of MIP image and averaged image was 0.941 and 0.655, respectively. On MIP images, the optimal threshold of the ratio on the affected and unaffected sides was 1.152 (sensitivity: 90.0%, and specificity: 93.3%).

Conclusion
The hyperdense MCA sign sensitivity on 5 mm MIP images was significantly higher than that on conventional 5 mm averaged CT images. This could be useful for the early initiation of proper therapy for patients with acute focal neurological deficits.
Validation of a LiDAR-based player tracking system during football-specific tasks
Authors: Bampouras Theodoros M. , Thomas Neil M. 
Published: May 2022

AbstractTracking players’ movements in sports is important to monitor and optimise exercise volume, avoid injuries, and enhance game performance. A new LiDAR-based system (Sportlight®) purports to provide accurate velocity and acceleration metrics derived from player movements. This study examined the validity of the LiDAR-based system against a 3D motion analysis system. Two competitive football players (age: 18 years, height: 1.74 ± 0.01 m, mass: 66.5 ± 7.8 kg; playing experience at this level: 3 years) completed nine trials each of six sport-specific movements, consisting of straight-line sprints, cuts, and curved runs. Trials were recorded concurrently by a four-unit LiDAR system and a 64-camera 3D motion analysis system. Instantaneous velocity and acceleration, and time spent within key performance indicator bands (defined by velocity and acceleration thresholds) were compared between systems. Agreement between the systems was evaluated by root mean square error. Differences in time spent within each key performance indicator band between systems were assessed with t tests and standardised effect sizes. Velocity root mean square error values ranged from 0.04 to 0.14 m·s−1 across all movements and acceleration root mean square error values ranged from 0.16 to 0.7 m·s−2. Differences between systems for time spent within each key performance indicator band were mostly trivial. These results show that the LiDAR-based system can provide valid measures of velocity and acceleration in football-specific tasks, thus providing accurate tracking of players and calculation of relevant key performance indicators.