bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oncological big data platforms for promoting digital competencies and professionalism in Chinese medical students: a cross-sectional study
Authors: Liu Jiahao , Jiao Xiaofei , Zeng Shaoqing , Li Huayi , Jin Ping , Chi Jianhua , Liu Xingyu , Yu Yang , Ma Guanchen , Zhao Yingjun , Li Ming , Peng Zikun , Huo Yabing , Gao Qing-Lei 
Published: September 2022

ObjectivesAdvancements in big data technology are reshaping the healthcare system in China. This study aims to explore the role of medical big data in promoting digital competencies and professionalism among Chinese medical students.Design, setting and participantsThis study was conducted among 274 medical students who attended a workshop on medical big data conducted on 8 July 2021 in Tongji Hospital. The workshop was based on the first nationwide multifunction gynecologic oncology medical big data platform in China, at the National Union of Real-World Gynecologic Oncology Research & Patient Management Platform (NUWA platform).Outcome measuresData on knowledge, attitudes towards big data technology and professionalism were collected before and after the workshop. We have measured the four skill categories: doctor‒patient relationship skills, reflective skills, time management and interprofessional relationship skills using the Professionalism Mini-Evaluation Exercise (P-MEX) as a reflection for professionalism.ResultsA total of 274 students participated in this workshop and completed all the surveys. Before the workshop, only 27% of them knew the detailed content of medical big data platforms, and 64% knew the potential application of medical big data. The majority of the students believed that big data technology is practical in their clinical practice (77%), medical education (85%) and scientific research (82%). Over 80% of the participants showed positive attitudes toward big data platforms. They also exhibited sufficient professionalism before the workshop. Meanwhile, the workshop significantly promoted students’ knowledge of medical big data (p<0.05), and led to more positive attitudes towards big data platforms and higher levels of professionalism.ConclusionsChinese medical students have primitive acquaintance and positive attitudes toward big data technology. The NUWA platform-based workshop may potentially promote their understanding of big data and enhance professionalism, according to the self-measured P-MEX scale.
Prevalence of nail biting and its chronological relationship with tics in child and adolescent outpatients with Tourette syndrome: a single-centre, retrospective observational study
Authors: Hsueh Chang-Wei , Chen Chia-Wen 
Published: September 2022

ObjectiveTo evaluate the prevalence of nail biting in child and adolescent outpatients at a single institution and the chronological relationship between nail biting and tics in patients with Tourette syndrome (TS) with or without attention-deficit hyperactivity disorder (ADHD).DesignRetrospective observational study.SettingTeaching hospital in Taiwan.ParticipantsAll participants were aged 4–18 years, including 535 patients with TS, 230 patients with provisional tic disorder and 1460 patients without neurological or psychiatric disorders (controls).Outcome measuresPresence of nail biting, starting age for nail biting and starting age for motor and/or vocal tics.ResultsNail biting was more commonly observed in patients with TS (56.6%) than in patients with provisional tic disorder (27.4%) or controls (15.0%), regardless of sex (all p<0.020). Nail biting was also more common in patients with TS with ADHD than in those without (75.0% vs 47.6%; p<0.001), but the starting age was significantly later in those with concomitant ADHD than without (5.3 vs 3.8 years; p<0.001). In patients with TS, the onset of nail biting occurred earlier than that of tics, regardless of ADHD status.ConclusionNail biting was more prevalent and occurred earlier than tics in patients with TS, regardless of ADHD status, in the study population.
Telephone-based cognitive behavioural therapy for patients with postoperative bariatric surgery to manage COVID-19 pandemic-related mental health issues and distress (TELE-BARICARE): a protocol for a randomised controlled trial
Authors: Sockalingam Sanjeev , Leung Samantha Eve , Agic Branka , Ma Clement , Hawa Raed , Wnuk Susan , Dash Satya , Jackson Timothy , Akbar Nadine , Forhan Mary , Cassin Stephanie E 
Published: September 2022

IntroductionBariatric surgery is currently the most effective treatment for obesity, and is performed yearly in over 8000 patients in Canada. Over 50% of those who live with obesity also have a history of mental health disorder. The COVID-19 pandemic has made it difficult for people living with obesity to manage their weight even after undergoing bariatric surgery, which combined with pandemic-related increases in mental health distress, has the potential to adversely impact obesity outcomes such as weight loss and quality of life. Reviews of virtual mental health interventions during COVID-19 have not identified any interventions that specifically address psychological distress or disordered eating in patients with obesity, including those who have had bariatric surgery.Methods and analysisA randomised controlled trial will be conducted with 140 patients across four Ontario Bariatric Centres of Excellence to examine the efficacy of a telephone-based cognitive behavioural therapy intervention versus a control intervention (online COVID-19 self-help resources) in postoperative bariatric patients experiencing disordered eating and/or psychological distress. Patients will be randomised 1:1 to either group. Changes in the Binge Eating Scale and the Patient Health Questionnaire 9-Item Scale will be examined between groups across time (primary outcomes). Qualitative exit interviews will be conducted, and data will be used to inform future adaptations of the intervention to meet patients’ diverse needs during and post-pandemic.Ethics and disseminationThis study has received ethics approvals from the following: Clinical Trials Ontario (3957) and the University Health Network Research Ethics Committee (22–5145), the Board of Record. All participants will provide written informed consent prior to enrolling in the study. Results will be made available to patients with bariatric surgery, the funders, the supporting organisations and other researchers via publication in peer-reviewed journals and conference presentations.Trial registration numberNCT05258578.
Recurrent 17q12 microduplications contribute to renal disease but not diabetes
Authors: Cannon Stuart , Clissold Rhian , Sukcharoen Kittiya , Tuke Marcus , Hawkes Gareth , Beaumont Robin N , Wood Andrew R , Gilchrist Mark , Hattersley Andrew T , Oram Richard A , Patel Kashyap , Wright Caroline , Weedon Michael N 
Published: September 2022

Background17q12 microdeletion and microduplication syndromes present as overlapping, multisystem disorders. We assessed the disease phenotypes of individuals with 17q12 CNV in a population-based cohort.MethodsWe investigated 17q12 CNV using microarray data from 450 993 individuals in the UK Biobank and calculated disease status associations for diabetes, liver and renal function, neurological and psychiatric traits.ResultsWe identified 11 17q12 microdeletions and 106 microduplications. Microdeletions were strongly associated with diabetes (p=2×10−7) but microduplications were not. Estimated glomerular filtration rate (eGFR mL/min/1.73 m2) was consistently lower in individuals with microdeletions (p=3×10−12) and microduplications (p=6×10−25). Similarly, eGFR <60, including end-stage renal disease, was associated with microdeletions (p=2×10−9, p<0.003) and microduplications (p=1×10−9, p=0.009), respectively, highlighting sometimes substantially reduced renal function in each. Microduplications were associated with decreased fluid intelligence (p=3×10−4). SNP association analysis in the 17q12 region implicated changes toHNF1Bas causing decreased eGFR (NC_000017.11:g.37741642T>G, rs12601991, p=4×10−21) and diabetes (NC_000017.11:g.37741165C>T, rs7501939, p=6×10−17). A second locus within the region was also associated with fluid intelligence (NC_000017.11:g.36593168T>C, rs1005552, p=6×10−9) and decreased eGFR (NC_000017.11:g.36558947T>C, rs12150665, p=4×10–15).ConclusionWe demonstrate 17q12 microdeletions but not microduplications are associated with diabetes in a population-based cohort, likely caused byHNF1Bhaploinsufficiency. We show that both 17q12 microdeletions and microduplications are associated with renal disease, and multiple genes within the region likely contribute to renal and neurocognitive phenotypes.
Reduced lung function and health-related quality of life after treatment for pulmonary tuberculosis in Gambian children: a cross-sectional comparative study
Authors: Nkereuwem Esin , Agbla Schadrac , Sallahdeen Azeezat , Owolabi Olumuyiwa , Sillah Abdou K , Genekah Monica , Tunkara Abdoulie , Kandeh Sheriff , Jawara Maryama , Saidy Lamin , Bush Andrew , Togun Toyin , Kampmann Beate 
Published: September 2022

BackgroundPost-tuberculosis (post-TB) lung disease is an under-recognised consequence of pulmonary tuberculosis (pTB). We aimed to estimate the prevalence of residual lung function impairment and reduced health-related quality of life (HRQoL) in children after pTB treatment completion.MethodsWe conducted a cross-sectional comparative study of children aged less than 15 years at TB diagnosis who had completed treatment for pTB at least 6 months previously with a comparator group of age-matched children without a history of pTB. Symptoms, spirometry and HRQoL measured with PedsQL scale were collected. Variables associated with lung function impairment were identified through logistic regression models.ResultsWe enrolled 68 post-TB cases (median age 8.9 (IQR 7.2–11.2) years) and 91 children in the comparison group (11.5 (8.0–13.7) years). Spirometry from 52 (76.5%) post-TB cases and 89 (94.5%) of the comparison group met the quality criteria for acceptability and repeatability. Lung function impairment was present in 20/52 (38.5%) post-TB cases and 15/86 (17.4%) in the comparison group, p=0.009. Previous pTB and a history of chronic cough were significantly associated with the presence of lung function impairment (p=0.047 and 0.006 respectively). Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVCz-scores were significantly lower in the post-TB cases compared with the comparison group (p= <0.001, 0.014 and <0.001, respectively). The distribution of the self-reported physical health score, and parent-reported physical, emotional, psychological, social and total HRQoL scores were significantly lower in the post-TB cases compared with the comparison group.ConclusionsPrevious TB in children is associated with significantly impaired lung function and HRQoL.
Beyond borders: cystic fibrosis survival between Australia, Canada, France and New Zealand
Authors: Coriati Adèle , Ma Xiayi , Sykes Jenna , Stanojevic Sanja , Ruseckaite Rasa , Lemonnier Lydie , Dehillotte Clémence , Tate Jan , Byrnes Catherine Ann , Bell Scott C , Burgel Pierre Regis , Stephenson Anne L 
Published: September 2022

BackgroundLife expectancy for people with cystic fibrosis (CF) varies considerably both within and between countries. The objective of this study was to compare survival among countries with single-payer healthcare systems while accounting for markers of disease severity.MethodsThis cohort study used data from established national CF registries in Australia, Canada, France and New Zealand from 2015 to 2019. Median age of survival for each of the four countries was estimated using the Kaplan-Meier method. A Cox proportional hazards model was used to compare risk of death between Canada, France and Australia after adjusting for prognostic factors. Due to low number of deaths, New Zealand was not included in final adjusted models.ResultsBetween 2015 and 2019, a total of 14 842 people (3537 Australia, 4434 Canada, 6411 France and 460 New Zealand) were included. The median age of survival was highest in France 65.9 years (95% CI: 59.8 to 76.0) versus 53.3 years (95% CI: 48.9 to 59.8) for Australia, 55.4 years (95% CI: 51.3 to 59.2) for Canada and 54.8 years (95% CI: 40.7 to not available) for New Zealand. After adjusting for individual-level factors, the risk of death was significantly higher in Canada (HR 1.85, 95% CI: 1.48 to 2.32; p<0.001) and Australia (HR 2.08, 95% CI: 1.64 to 2.64; p<0.001) versus France.InterpretationWe observed significantly higher survival in France compared with countries with single-payer healthcare systems. The median age of survival in France exceeded 60 years of age despite having the highest proportion of underweight patients which may be due to differences in availability of transplant.
Spatial dependency and independency of nitrogen in lowbush blueberry commercial fields
Authors: Pelletier Anthony J. , Lafond Jean , Paré Maxime C. 
Published: September 2022

Rhizomes of wild lowbush blueberry ( Vaccinium angustifolium Aiton) extend horizontally, creating spatial dependency when fertilization trials are performed. Knowing this spatial dependency would help researchers to better design field studies. Here, we used labelled nitrogen (N) fertilizer (15N-(NH4)2SO4) to measure N translocation among blueberry stems for one old (56 year) and one younger (15 year) commercial field. Leaf 15N concentrations at the tip-dieback stage were used to monitor N acquisition. No difference between sites suggests no field age effect on N translocation. Spatial dependency and independency were reached for distances of ≤0.75 and ≥1.75 m from the fertilizer application point, respectively.
EpIC: novel Monte Carlo generator for exclusive processes
Authors: Aschenauer E. C. , Batozskaya V. , Fazio S. , Gates K. , Moutarde H. , Sokhan D. , Spiesberger H. , Sznajder P. , Tezgin K. 
Published: September 2022

AbstractWe present the EpIC Monte Carlo event generator for exclusive processes based on generalised parton distributions. EpIC utilises the PARTONS framework, which provides a flexible software architecture and a variety of modelling options for the partonic description of the nucleon. The generator offers a comprehensive set of features, including simulation of a variety of exclusive processes and radiative corrections. It may be used both in the analysis of experimental data, as well as for impact studies, especially for the future electron-ion colliders.
Spatiotemporal jumps as particular solutions in geodesic trajectories with the Gödel metric on an extended manifold
Authors: Bellini Mauricio 
Published: September 2022

AbstractUsing the Gödel metric, we obtain some relevant solutions compatible with spatiotemporal jumps for the geodesic equations, by using an extension of General Relativity with nonzero boundary terms, which are described on an extended manifold generated by the connections $$\delta \Gamma ^{\mu }_{\alpha \beta } = b\,U^{\mu }\,g_{\alpha \beta }$$

δ

Γ

α
β

μ

=
b

U
μ

g

α
β

. These terms are given by a flow of velocities with components $$U^{\nu }$$

U
ν

: $$3\,b^2\,\nabla _{\nu }U^{\nu }=g^{\alpha \beta }\, \delta R_{\alpha \beta } = \lambda \left[ s\left( x^{\alpha }\right) \right] \,g^{\alpha \beta }\, \delta g_{\alpha \beta }$$

3

b
2

∇
ν

U
ν

=

g

α
β

δ

R

α
β

=
λ

s

x
α

g

α
β

δ

g

α
β

in the varied Einstein–Hilbert action. The solutions are valid for an arbitrary equation of state with ordinary matter: $$\Omega =P/(c^2\,\rho ) = \frac{\left( \frac{\omega }{c}\right) ^2-\lambda (s)}{\left( \frac{\omega }{c}\right) ^{2}+\lambda (s)}$$

Ω
=
P
/

(

c
2

ρ
)

=

ω
c

2

-
λ

(
s
)

ω
c

2

+
λ

(
s
)

.
Constraining extra dimensions using observations of black hole quasi-normal modes
Authors: Mishra Akash K. , Ghosh Abhirup , Chakraborty Sumanta 
Published: September 2022

AbstractThe presence of extra dimensions generically modify the spacetime geometry of a rotating black hole, by adding an additional hair, besides the mass M and the angular momentum J, known as the ‘tidal charge’ parameter, $$\beta $$
β
. In a braneworld scenario with one extra spatial dimension, the extra dimension is expected to manifest itself through – (a) negative values of $$\beta $$
β
, and (b) modified gravitational perturbations. This in turn would affect the quasi-normal modes of rotating black holes. We numerically solve the perturbed gravitational field equations using the continued fractions method and determine the quasi-normal mode spectra for the braneworld black hole. We find that increasingly negative values of $$\beta $$
β
correspond to a diminishing imaginary part of the quasi-normal mode, or equivalently, an increasing damping time. Using the publicly available data of the properties of the remnant black hole in the gravitational wave signal GW150914, we check for consistency between the predicted values (for a given $$\beta $$
β
) of the frequency and damping time of the least-damped $$\ell =2,m=2$$

ℓ
=
2
,
m
=
2

quasi-normal mode and measurements of these quantities using other independent techniques. We find that it is highly unlikely for the tidal charge, $$\beta \lesssim -0.05$$

β
≲
-
0.05

, providing a conservative limit on the tidal charge parameter. Implications and future directions are discussed.
Study on the Influencing Factors of Osteoarthritis in Southern China
Authors: Lu Danqing , Ding Xiaomin , Lu Wenqing 
Published: September 2022

Background. Osteoarthritis (OA) is a common chronic disease with numerous and interacting influencing factors, and current inadequate patient perceptions and behaviors in access to care contribute to the difficulties in the diagnosis, treatment, and management of osteoarthritis. Objective. The purpose of this study was to investigate the influencing factors of osteoarthritis (OA) in a southern Chinese population and to provide a scientific basis for the prevention and treatment of OA. Methods. A 1 : 2 matched case-control study was used to select 160 patients with OA from three hospitals in southern China as a case group. Three hundred and twenty cases of the same sex and similar age (within

±

2 years) were selected as the control group, and relevant data were collected for univariate and multivariate conditional logistic regression analysis. Results. There were no significant differences between the two groups of participants in terms of age, sex, and education (

P
>
0.05

). Logistic regression statistical analysis showed that genetic factors (OR = 4.52, 95% CI = 1.56–7.83), body mass index (OR = 2.57, 95% CI = 1.16–5.84), alcohol consumption (OR = 3.81, 95% CI = 1.53–5.87), and a history of external joint limb injury (OR = 3.37, 95% CI = 1.67–5.24) would increase the risk of OA. In contrast, eating more fresh vegetables (OR = 0.08, 95% CI = 0.03–0.31), more fresh fruits (OR = 0.34, 95% CI = 0.12–0.96), more soy products (OR = 0.11, 95% CI = 0.04–0.45), and exposure to sunlight (OR = 0.31, 95% CI = 0.14–0.71) would reduce the OA risk of OA. Conclusion. Obesity, alcohol consumption, and a history of joint trauma all increase the risk of OA in a southern Chinese population, whereas a diet rich in fresh vegetables, fresh fruit, soy products, and sun exposure would reduce the risk of OA. In the future, we should focus on improving patients’ awareness of medical care and developing their self-management skills, improving GPs’ treatment skills, improving negative attitudes of both doctors and patients, and promoting positive patient care.
Identification of Prognostic Factors in Cholangiocarcinoma Based on Integrated ceRNA Network Analysis
Authors: Jin Haili , Liu Wei , Xu Weiming , Zhou Liping , Luo Huarong , Xu Cheng , Chen Xi , Chen Wenbin 
Published: September 2022

This study is aimed at screening prognostic biomarkers in cholangiocarcinoma (CHOL) based on competitive endogenous RNA (ceRNA) regulatory network analysis. Microarray data for lncRNAs, mRNA, and miRNAs were downloaded from the GEO and TCGA databases. Differentially expressed RNAs (DERs) were identified in CHOL and normal liver tissue samples. WGCNA was used to identify disease-related gene modules. By integrating the information from the starBase and DIANA-LncBasev2 databases, we constructed a ceRNA network. Survival analysis was performed, and a prognostic gene-based prognostic score (PS) model was generated. The correlation between gene expression and immune cell infiltration or immune-related feature genes was analyzed using TIMER. Finally, real-time quantitative PCR (RT-qPCR) was used to verify the expression of the 10 DERs with independent prognosis. A large cohort of DERs was identified in the CHOL and control samples. The ceRNA network consisted of 6 lncRNAs, 2 miRNAs, 90 mRNAs, and 98 nodes. Ten genes were identified as prognosis-related genes, and a ten-gene signature PS model was constructed, which exhibited a good prognosis predictive ability for risk assessment of CHOL patients (

AUC

value
=
0.975

). Four genes, ELF4, AGXT, ABCG2, and LDHD, were associated with immune cell infiltration and closely correlated with immune-related feature genes (CD14, CD163, CD33, etc.) in CHOL. Additionally, the consistency rate of the RT-qPCR results and bioinformatics analysis was 80%, implying a relatively high reliability of the bioinformatic analysis results. Our findings suggest that the ten-signature gene PS model has significant prognostic predictive value for patients with CHOL. These four immune-related DERs are involved in the progression of CHOL and may be useful prognostic biomarkers for CHOLs.
An Evaluation of Replacing Fishmeal with Chlorella Sorokiniana in the Diet of Pacific White Shrimp (Litopenaeus Vannamei): Growth, Body Color, and Flesh Quality
Authors: Li Menglu , Li Xiaoqin , Yao Wenxiang , Wang Yuanyuan , Zhang Xin , Leng XiangJun 
Published: September 2022

This study was conducted to investigate the effects of replacing fishmeal (FM) with Chlorella sorokiniana on growth and flesh quality of Pacific white shrimp, Litopenaeus vannamei. A control diet was formulated to contain 560 g/kg FM, and then chlorella meal was used to replace 0% (C-0), 20% (C-20), 40% (C-40), 60% (C-60), 80% (C-80), and 100% (C-100) of dietary FM, respectively. The six isoproteic and isolipidic diets were fed to shrimp (

1.37
±
0.02

g) for 8 weeks. The results showed that weight gain (WG) and protein retention (PR) of C-20 group were significantly higher than those of C-0 group (

P
<
0.05

), while no significant differences were observed in WG and PR between C-0 and C-40 groups (

P
>
0.05

). When the replaced level of FM by chlorella meal reached 60%, the WG of shrimp decreased and feed conversion ratio (FCR) increased significantly (

P
<
0.05

). The quadratic regression analysis indicated that substituted fishmeal levels with chlorella meal were 20.50% and 28.25%, respectively, to obtain the highest WG and lowest FCR. In C-40 and C-60 groups, the body surface presented higher redness than the control (

P
<
0.05

). No significant differences in the whole body and muscle composition, SOD, T-AOC, GSH-PX activities, MDA contents, total collagen content, steaming loss, texture property, free delicious amino acids contents, PUFAs, and n-3/n-6 PUFAs in flesh were observed among the three groups of C-0, C-20, and C-40 (

P
>
0.05

). Compared to the control group, C-60, C-80, and C-100 groups showed lower flesh hardness, chewiness, shear force, and higher steaming loss and resilience (

P
<
0.05

). There were no significant differences in serum TP, TG, GLU, and ALB contents, boiling loss, freezing loss, total free amino acids, SAFs and MUFAs among all the groups (P >0.05). Conclusively, in a diet containing 560 g/kg FM, chlorella meal could replace 40% dietary FM without negative effects on the growth and flesh quality, while increase the body redness of white shrimp.