bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of dental training and distance of the observer on the perception of apically shifted gingival margin with increased vertical tooth size in the esthetic zone
Authors: Montevecchi Marco , Desimini Fabio Paolo , Sforza Nicola , Bagattoni Simone , Piana Gabriela 
Published: November 2022

AbstractObjectivesTo evaluate the influence of the gingival contour on the smile esthetics. The influence of size, symmetry, teeth involved in apically shifted gingival margins, and the distance and clinical training of the observer were investigated.Materials and MethodsTwo groups were identified: 33 first‐year dental students (inexperienced) and 40 last‐year students (trained). Each observer expressed four evaluations on four different images assigning a score from 0 to 10. Using a picture of an “ideal” female smile, 10 variants were virtually created by shifting (2 and 4 mm) the gingival contour apically at different sites of the upper incisors and canines. A total of 292 evaluations were collected.ResultsConsidering a score >6 for a “pleasant smile,” only one 4 mm single alteration at the canine gingival contour obtained an insufficient score. “Observational distance” and “clinical training” did not influence the final score, while size and symmetry of alterations displayed a significant role.ConclusionsThe dental training of the observer and a close interpersonal distance seemed to be irrelevant in the esthetic perception of gingival margin alterations.
Determinants of corporate social responsibility performance in emerging markets: An international orientation perspective
Authors: Li Peng‐Yu 
Published: November 2022

AbstractFor emerging market multinational enterprises (EMNEs), corporate social responsibility (CSR) is a foreign business practice. Because EMNEs are late movers in the international market, their attempts to engage in sustainable development and to improve CSR performance (CSP) are hindered by their limited relevant knowledge and resources. Few studies have investigated how EMNEs achieve high CSP. In this study, a sample of 177 Taiwanese companies in Taiwan listed on the Taiwan Stock Exchange from 2013 to 2015 was examined. Data were collected from the Taiwan Economic Journal database. The effects of international orientation on the level of internationalization, market entry in advanced economies, and adherence to international CSR principles on the CSP of these EMNEs were investigated. The results revealed that higher levels of internationalization, greater market entry in advanced economies, and adherence to international CSR principles are positively related to CSP. In addition, a higher level of internationalization enhances the relationship between adherence to international CSR principles and CSP.
Cross‐sectoral information and actors' contact networks in natural resource governance in the Swiss Alps
Authors: Huber Martin Nicola , Fischer Manuel , Egli Nicolas 
Published: November 2022

AbstractGovernance of natural resources is challenging due to cross‐sectoral dependencies across related sectors such as, for example, water, agriculture, and energy. Actors involved in natural resource governance create network contacts with each other, in order to deal with specific governance issues. An important resource for actors is information, and actors act according to the amount of information they have about other related sectors. In this article, we study how the information actors possess about different sectors is related to their contact network across sectors. We empirically study a case of water management in the Swiss mountain valley of Engadin. We use descriptive and inferential network analysis to show that actors with more information about other sectors establish more contacts in general, as well as with actors from those other sectors. We conclude that successful natural resource governance hinges upon the information that actors have about other sectors related to their sector.
Transition Metal Borate Complexes Containing κ0‐κ6 Denticity of Scorpionate Borate Ligands
Authors: Saha Suvam , Assanar Faneesha , Ghosh Sundargopal 
Published: November 2022

AbstractThe recent developments in the field of transition metal (TM) borate complexes have been a landmark in modern coordination chemistry. The structural diversities of these complexes play an important role in several catalytic processes. Generally, polypyrazolyl borate ligands, [BHn(pz)4‐n]− (n=1, 2; pz=pyrazolyl), popularly known as scorpionates have been used extensively for the preparation of TM borate complexes. The presence of multiple donor atoms in the flexible borate proligands led to several coordination modes. Based on the electronic and steric properties of these ligands and the metals, the denticity of borate ligands in TM complexes varied from κ0 to κ6. The presence of different bonding modes of these borate ligands made them very interesting in main group organometallic chemistry. In addition, cooperative activation of boranes by TM complexes containing metal‐nitrogen or metal‐sulfur bonds has become an alternative to the utilization of borate proligands for the synthesis of TM borate complexes. This review summarizes the advancements of the chemistry of TM borate complexes focusing exclusively on the synthetic methods and various bonding scenarios.
Molybdenum Incorporated Strontium‐Iron and Strontium‐Cobalt (SrBMoO3−δ; B=Fe & Co) Perovskites: Preparation and Their Application on Oxidation of Iso‐Eugenol into Vanillin
Authors: Bhavisha Meloth , Aswani Saralabhai , Sreenavya Awadakkam , Neethu P. Purayil , Archana I. Gopinathan , Balamurugan Sarkarainadar , Ganesh Venkatachalam , Sakthivel Ayyamperumal 
Published: November 2022

AbstractSrBO3−δ (B=Fe & Co) type perovskite oxides and their 25 % molybdenum doped counterparts, SrFe0.75Mo0.25O3−δ (SFMO) and SrCo0.75Mo0.25O3−δ (SFCO) are synthesized by the conventional solid‐state method and systematically characterized using Fourier transfer infrared spectroscopy, powder X‐ray diffraction, thermo‐gravimetric analysis, nitrogen sorption, and temperature‐programmed reduction. The powder X‐ray diffraction patterns and FTIR spectral analysis evident the formation of the pure cubic phase and the doping of molybdenum into the perovskite crystal lattice. The variable oxidation states of iron and cobalt and the formation of oxygen vacancies are apparent from the TPR‐H2 and TGA curves, respectively. All of the samples have a lower surface area than porous materials, which is typical of the bulk oxide character. The iron‐based perovskite demonstrated superior activity to the cobalt‐based one for the oxidation of iso‐eugenol to 4‐hydroxy‐3‐methoxybenzaldehyde (vanillin) when employing aqueous H2O2 as the oxidant. The maximum conversion of 73 % with 63 % selectivity for vanillin was obtained within 1.5 h at 60 °C over the SFMO catalyst. The catalytic conversion was almost similar upon re‐use of the catalyst.
Improving the Measurement of Iron(III) Bioavailability in Freshwater Samples: Methods and Performance
Authors: Balsamo Crespo Emiliano , Reichelt-Brushett Amanda , Smith Ross E. W. , Rose Andrew L. , Batley Graeme E. 
Published: November 2022

Abstract
The toxicity of iron(III) in fresh waters has been detected at concentrations above the iron solubility limit, indicating a contribution of colloidal and particulate forms of iron(III) to the toxicity response. Current water quality guideline values for iron in fresh water are based on analytical determinations of filterable or total iron. Filtration, however, can underestimate bioavailable iron by retaining some of the colloidal fraction, and total determinations overestimate bioavailable iron measurements by recovering fractions of low bioavailability from suspended solids (e.g., iron oxides and oxyhydroxides) naturally abundant in many surface waters. Consequently, there is a need for an analytical method that permits the determination of a bioavailable iron fraction, while avoiding false-negative and false-positive results. Ideally, a measurement technique is required that can be readily applied by commercial laboratories and field sampling personnel, and integrated into established regulatory schemes. The present study investigated the performance of pH 2 and pH 4 extractions to estimate a bioavailable iron(III) fraction in synthetic water samples containing iron phases of different reactivities. The effects of aging on fresh precipitates were also studied. The total recoverable, 0.45-µm filtered, and pH 4 extractable fractions did not discriminate iron phases and age groups satisfactorily. Contrastingly, the pH 2 extraction showed specificity toward iron phases and aging (0.5–2-h interval). Extraction times above 4 h and up to 16 h equally recovered &gt;90% of the spiked iron regardless of its age. Furthermore, &lt;1% of the well-mineralized iron was targeted. The present study shows that a pH 2 dilute-acid extraction is a suitable candidate method to operationally define iron fractions of higher bioavailability avoiding false-negative and false-positive results. Environ Toxicol Chem 2023;42:303–316. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Predictive power of the implied volatility term structure in the fixed‐income market
Authors: Chen Ren‐Raw , Hsieh Pei‐Lin , Huang Jeffrey , Li Xiaowei 
Published: November 2022

AbstractWe apply the interest rate model of Chen, Hsieh, and Huang (CHH), the CHH model, to explore the implied volatility (IV) term structure's predictive power for bond excess returns. The CHH model has two advantages over existing models: (1) it delivers the IV of the interest rate, rather than the volatility of the swap rate on which the conventional swaption pricing model is built, and (2) the CHH model systematically summarizes 100 swaption prices into a volatility term structure with 10 succinct IVs. By exploiting these advantages, we demonstrate the IV term structure's predictive power and its connection to economic conditions.
The global, regional and national epidemiology, incidence, mortality, and burden of ovarian cancer
Authors: Mazidimoradi Afrooz , Momenimovahed Zohre , Allahqoli Leila , Tiznobaik Azita , Hajinasab Negar , Salehiniya Hamid , Alkatout Ibrahim 
Published: November 2022

AbstractBackgroundOvarian cancer has the highest mortality rate among gynecological malignancies and is associated with poor prognosis. Since the accurate assessment of the global burden along with the trend of cancers contributes to the development of policies, this study aimed to explain the incidence, mortality, and burden of ovarian cancer using the global burden of disease (GBD) 2019 study.MethodsEpidemiological data have been collected from the study of the GBD 2019. Data were extracted globally for 204 countries and groups based on a socio‐demographic index (SDI), WHO regions, continents, World Bank regions, and 22 GBD regions.ResultsIn 2019, a total of 294,422 new cases of ovarian cancer were reported. The highest age‐standardized incidence rate (ASIR) was reported in areas with higher SDI, World high‐income countries, continental Europe, and then America. In GBD regions, the highest age‐standardized incidence is in Central Europe. In 2019, a total of 198,412 deaths due to ovarian cancer were reported. The highest ASR death is related to countries with high SDI and the World Bank high‐income countries. In 2019, adjusted years of life with disabilities (DALYs) due to ovarian cancer were reported to be 5,359,737, of which 5,205,660 were related to lost years of life (YLLs), and 154,077 were related to years of life with disabilities (YLDs).ConclusionsIn 2019, the highest age‐standardized incidence of ovarian cancer, ASR death, and DALYs ASR belong to the high SDI countries. Designing interventions based on risk factors as well as providing preventive approaches to reduce the risk of this cancer, improving the treatment of ovarian cancer, and using appropriate and invasive treatments are recommended.
The relationship between cumulative dose of immunosuppressive agents and COVID‐19‐associated mucormycosis: A multicenter cross‐sectional study
Authors: Rastkar Mohsen , SeyedAlinaghi SeyedAhmad , Asanjarani Behzad , Siri Goli , Abdollahi Hamed , Ghadami Ladan , Hasibi Mehrdad , Khodashahi Rozita , Bagheri AmirBehzad , Asadollahi‐Amin Ali 
Published: November 2022

AbstractBackground and AimsImmunosuppressive therapy has a key role in developing coronavirus disease‐2019 (COVID‐19)‐associated mucormycosis. In this study, we investigated the effect of the type and cumulative dose of immunosuppressive agents on COVID‐19‐associated mucormycosis.MethodsWe designed a descriptive cross‐sectional study involving three COVID‐19 hospitals in Iran. Clinical and demographic data were gathered from the medical records and checked by two independent researchers to minimize errors in data collection.ResultsSeventy‐three patients were included in the study. The mean age of cases was 57.41 (SD = 12.64) and 43.8% were female. Among patients, 20.5% were admitted to the intensive care unit (ICU) during COVID‐19. Furthermore, 17 patients (23.29%) had a history of diabetes mellitus. Sixty‐nine patients (94.52%) had a history of receiving corticosteroids (dexamethasone) during treatment of COVID‐19, and of those, five patients (6.85%) received Tocilizumab beside. The mean cumulative dose of corticosteroids prescribed was 185.22 mg (SD = 114.738). The average cumulative dosage of tocilizumab was 720 mg (SD = 178.89). All of the included patients received amphotericin B for mucormycosis treatment, and 42 survived (57.53%). Also, there was a significant relationship between hospitalization in ICU for COVID‐19 and the mucormycosis outcome (p = 0.007). However, there weren't any significant associations between cumulative doses of immunosuppressive drugs and mucormycosis outcome (p = 0.52).ConclusionThe prevalence of COVID‐19‐associated mucormycosis is increasing and should be considered in the treatment protocols of COVID‐19. Controlling risk factors such as diabetes, malignancy and the administration of immunosuppressive agents based on recommended dosage in validated guidelines are ways to prevent mucormycosis.
Preliminary report of Iranian Registry of Alzheimer's disease in Tehran province: A cross‐sectional study in Iran
Authors: Fahanik‐Babaei Javad , Sedighi Mohsen , Mehrabi Soraya , Pournik Omid , Sheikh Taheri Abbas , Kamalzadeh Leila , Zarei Mahsa , Roghani Mehrdad , Golab Fereshteh , Almasi Mostafa , Etezadi Afshin , Afshin‐Majd Siamak , Malakouti Seyed Kazem , Rajabi Majid , Moghaddasi Mehdi , Hajati Gholamreza , Golmohammadi Khamne Fatemeh , Jafari Arzhang , Amanollahi Alireza , Baluchnejadmojarad Tourandokht 
Published: November 2022

AbstractBackground and AimsAlzheimer's disease (AD) is the main cause of dementia and over the 55 million people live with dementia worldwide. We aimed to establish the first database called the Iranian Alzheimer's Disease Registry to create a powerful source for future research in the country. In this report, the design and early results of the Iranian Alzheimer's Disease Registry will be described.MethodsWe performed this multicenter investigation and patients' data including age, sex, educational level, disease status, Mini‐Mental State Examination (MMSE), and Geriatric Depression Scale (GDS) from 2018 to 2021 were collected, registered, and analyzed by GraphPad Prism software.ResultsTotally 200 AD patients were registered in our database. 107 (54%) were women and age of 147 (74%) were over 65. The mean age for men and women was 76.20 ± 8.29 and 76.40 ± 8.83 years, respectively. 132 (66%) were married and 64 (32%) were illiterate. Also, 94 (47%) were in the moderate stage of disease, and 150 (75%) lived at home together with their families. The most frequent neurological comorbidity was psychosis (n = 72, 36%), while hypertension was the most common non‐neurological comorbidity (n = 104, 52%). The GDS score of women in the mild stage (5.23 ± 2.9 vs. 6.9 ± 2.6, p = 0.005) and moderate stage (5.36 ± 2.4 vs. 8.21 ± 2.06, p = <0.001) of the disease was significantly greater than men. In univariate analysis, MMSC score was remarkably associated with stroke (β = −2.25, p = 0.03), psychosis (β = −2.18, p = 0.009), diabetes (β = 3.6, p = <0.001), and hypercholesteremia (β = 1.67, p = 0.05). Also, the MMSE score showed a notable relationship with stroke (β = −2.13, p = 0.05) and diabetes (β = 3.26, p = <0.001) in multivariate analysis.ConclusionIranian Alzheimer's Disease Registry can provide epidemiological and clinical data to use for purposes such as enhancing the current AD management in clinical centers, filling the gaps in preventative care, and establishing effective monitoring and cure for the disease.
Feasibility study of use of desflurane combined with dexmedetomidine in inhibiting postoperative neurocognitive disorders in elderly patients under general anesthesia: A perspective study
Authors: Hu Yue , Ye Yong , Lin Hui , Chen Jun‐Jie , Sun Ting‐Ting , Zhang Gong‐Wei , Wang Na , Shu Yuan‐Hang , Gong Xue , Ran Fei‐Fei , Zhang Jia‐Li , Tao Yong 
Published: November 2022

AbstractThis study aimed to explore whether the combined application of desflurane and dexmedetomidine (Dex) reduces the occurrence of postoperative neurocognitive disorders (PND) in patients. We selected patients in our hospital who underwent surgery under general anesthesia, and divided them into two groups: Dex and desflurane (Dex + Des) and desflurane (Des) groups. The data of patients were collected and the Mini‐Mental State Examination (MMSE) score was used to assess cognitive status. The blood cell counts were determined preoperatively and on postoperative days 1, 3, and 6, and the percentage of neutrophils and lymphocytes were also recorded. The statistical methods used were the independent‐samples t‐test and the χ2 test. Pearson's correlation was used to analyze the correlation between PND and inflammation. The incidence of PND in the Dex + Des group was lower than that in the Des group. The postoperative MMSE scores in the Dex + Des group were higher than those in the Des group (p = 0.032). The percentage of neutrophils in the Dex + Des group was significantly lower than that in the Des group on the first and third days after surgery (p = 0.007; p = 0.028). The MMSE scores on the first day after surgery were negatively correlated with the multiple changes in white blood counts and the percentage of neutrophils (r = −0.3038 and −0.3330). Dex combined with Des reduced the incidence of PND and reduced the postoperative inflammatory cell counts.
The rapid implementation of a pharmacy student vaccination program with the Department of Health to increase the delivery of intradermal monkeypox vaccinations
Authors: Denninger Jade , Jakeman Bernadette , Arnett Jonathan , Bachyrycz Amy 
Published: November 2022

AbstractThe monkeypox virus is an orthopoxvirus, which is in the same family of viruses as the variola virus that causes smallpox. The United States (US) has documented the largest number of monkeypox globally with a reported 28 000 people infected. The greatest number of cases in the United States have been reported in men, ages 31–40. More than 90% of US cases between 17 May and 22 July 2022 were reported in men who reported recent sex or close contact with a man. Because of New Mexico's unique experience with pharmacist‐administered tuberculin skin testing, pharmacists and pharmacy students were in a position to fill a community needs to provide intradermal monkeypox vaccinations. Pharmacy students at the University of New Mexico administered 355 subcutaneous doses and 534 intradermal doses of the monkeypox vaccine. The purpose of this manuscript is to highlight how pharmacy student interns can be successfully trained to vaccinate using the intradermal route of administration and provide patient care during this public health outbreak.
Blockage of MDM2‐mediated p53 ubiquitination by yuanhuacine restrains the carcinogenesis of prostate carcinoma cells by suppressing LncRNA LINC00665
Authors: Yan Miao , Li Xin , Gu Jinbao , Gao Guojun , Wu Ziyu , Xue Peng 
Published: November 2022

AbstractProstate cancer (PCa) is a challenging issue for men's health worldwide due to its uncontrolled proliferation and high metastatic potential. Increasing evidence has supported plant extracts and natural plant derivatives as promising antitumor therapy with less toxic side effects. Yuanhuacine is an active component isolated from Daphne genkwa and can effectively suppress the tumorigenesis of several cancers. However, its role in PCa remains unclear. In this study, yuanhuacine dose‐dependently inhibited the proliferation and induced apoptosis of PCa cells. Moreover, yuanhuacine also restrained the invasion and migration of PCa cells. Mechanically, yuanhuacine decreased the ubiquitination and degradation of p53 protein, and ultimately increased p53 levels, which was regulated by inhibiting the phosphorylation and total protein levels of mouse double minute 2 (MDM2). Moreover, elevation of MDM2 reversed the suppressive efficacy of yuanhuacine in PCa cell viability, invasion, and migration. The network pharmacologic and bioinformatics analysis confirmed that MDM2 might be a common target of D. genkwa and LINC00665. Furthermore, yuanhuacine inhibited LINC00665 expression. Upregulation of LINC00665 reversed yuanhuacine‐mediated inhibition in MDM2 protein expression and suppressed p53 levels by enhancing its ubiquitination in yuanhuacine‐treated cells. Importantly, the inhibitory effects of yuanhuacine on cell viability and metastatic potential were offset after LINC00665 elevation. Together, the current findings highlight that yuanhuacine may possess tumor‐suppressive efficacy by inhibiting LINC00665‐mediated MDM2/p53 ubiquitination signaling. Therefore, this study indicates that yuanhuacine may be a promising candidate for the treatment of PCa.
Performance projection of multi‐bias and nonlinear distortion for gallium arsenides nano‐pHEMT
Authors: Alim Mohammad A. , Sultana Sadia , Naima Jannatul , Jui Fahmida S. , Alam Sabrina , Rezazadeh Ali A. 
Published: November 2022

AbstractIntermodulation distortion tests using the two‐tone technique with an extensive bias range were used to demonstrate the nonlinearity in terms of frequency for active devices like nano pHEMT based on gallium arsenide semiconductor material. It is demonstrated that the intermodulation distortion components are directly connected to the RF transconductance derivatives calculated using the two‐tone test. Furthermore, it was discovered that the third‐order intermodulation distortion power is lowest when the second derivative of the transconductance Gm3is zero. To emphasize the influence of RF transconductance, a two‐tone approach has been presented as an empirical, analytical explanation for this device's nonlinearity. The modeled data is demonstrated to agree with the results of the measurements, making it a helpful tool for analyzing these devices.