bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wearing the Future—Wearables to Empower Users to Take Greater Responsibility for Their Health and Care: Scoping Review
Authors: Kang Harjeevan Singh , Exworthy Mark 
Published: July 2022

Background
Wearables refer to devices that are worn by individuals. In the health care field, wearables may assist with individual monitoring and diagnosis. In fact, the potential for wearable technology to assist with health care has received recognition from health systems around the world, including a place in the strategic Long Term Plan shared by the National Health Service in England. However, wearables are not limited to specialist medical devices used by patients. Leading technology companies, including Apple, have been exploring the capabilities of wearable health technology for health-conscious consumers. Despite advancements in wearable health technology, research is yet to be conducted on wearables and empowerment.

Objective
This study aimed to identify, summarize, and synthesize knowledge on how wearable health technology can empower individuals to take greater responsibility for their health and care.

Methods
This study was a scoping review with thematic analysis and narrative synthesis. Relevant guidance, such as the Arksey and O’Malley framework, was followed. In addition to searching gray literature, we searched MEDLINE, EMBASE, PsycINFO, HMIC, and Cochrane Library. Studies were included based on the following selection criteria: publication in English, publication in Europe or the United States, focus on wearables, relevance to the research, and the availability of the full text.

Results
After identifying 1585 unique records and excluding papers based on the selection criteria, 20 studies were included in the review. On analysis of these 20 studies, 3 main themes emerged: the potential barriers to using wearables, the role of providers and the benefits to providers from promoting the use of wearables, and how wearables can drive behavior change.

Conclusions
Considerable literature findings suggest that wearables can empower individuals by assisting with diagnosis, behavior change, and self-monitoring. However, greater adoption of wearables and engagement with wearable devices depend on various factors, including promotion and support from providers to encourage uptake; increased short-term investment to upskill staff, especially in the area of data analysis; and overcoming the barriers to use, particularly by improving device accuracy. Acting on these suggestions will require investment and constructive input from key stakeholders, namely users, health care professionals, and designers of the technology. As advancements in technology to make wearables viable health care devices have only come about recently, further studies will be important for measuring the effectiveness of wearables in empowering individuals. The investigation of user outcomes through large-scale studies would also be beneficial. Nevertheless, a significant challenge will be in the publication of research to keep pace with rapid developments related to wearable health technology.
Peritoneal dialysis in 2022: an accidental renaissance?
Authors: Ivanov Dmytro D. 
Published: July 2022

The review focuses on peritoneal dialysis as a renal replacement therapy for stage 5 chronic kidney disease (CKD). About 10 % of the world’s population suffers from CKD, but its prevalence and incidence vary widely across the world due to social and economic conditions. The main areas of renal replacement therapy today are haemodialysis and peritoneal dialysis, the beginning of which is recommended for CKD stage 5. Both methods are effective and have similar survival and mortality rates. Both techniques are used successfully around the world, but peritoneal dialysis is less resource-intensive, making it the method of choice in many less affluent countries. The advantages of peritoneal dialysis can be: shorter sessions, limited patient movement, being in the family circle and better quality of life according to the patients themselves. Numerous studies are being conducted to improve the reliability and quality of peritoneal dialysis, including access and prevention of infections.
Clinical case of hydronephrotic form of multicystic dysplastic kidney complicated by pyelonephritis in adults
Authors: Chub O.I. , Reshetniak S.O. , Dumanskiy Yu.V. , Maltsev A.V. 
Published: July 2022

Multicystic dysplastic kidney (MCDK) is a renal dysplasia characterized by the presence of multiple cysts that are non-communicating, varying in size, separated by dysplastic parenchyma that consume the renal cortex resulting in a non-functional kidney with the absence of a normal pelvocaliceal system. The incidence of MCDK is approximately 1 : 4300 of live births, with males being affected more often than females. Many concurrent urinary tract abnormalities have been described in patients with MCDK. The most common and potentially significant urologic defect seen is vesico-ureteral reflux to the contralateral kidney. In our clinical case, multicystic dysplastic kidney complicated by hydronephrotic transformation and septic obstructive pyelonephritis, which developed on the base of undiagnosed vasorenal conflict.
Desarrollo de habilidades para la vida en estudiantes universitarios por medio de un programa de asignaturas electivas: un análisis de coincidencia de percepciones
Authors: García Sicard Nadia , Saldaña Medina Caleb , Salamanca Gómez Sophia , Jiménez Roa Daniel 
Published: July 2022

El futuro del estudiantado depende de la medida en que este desarrolle las llamadas Habilidades para la Vida, especialmente aquellas relacionadas con el currículo académico. De ahí la importancia de evaluarlas. Este estudio explora el grado de coincidencia entre la percepción de profesores, monitores y estudiantes acerca de las habilidades para la vida, que se desarrollan en cuatro asignaturas electivas de la Universidad del Rosario, Colombia. Las percepciones se obtuvieron por medio de tres métodos de recolección: grupos focales, observación participativa y un cuestionario. Los resultados mostraron un porcentaje de coincidencia entre los y las participantes Sobre cuáles habilidades se desarrollaron, los resultados mostraron un porcentaje de coincidencia entre los y las participantes de 34,8% en la electiva de Enología, 55% en el Taller de Escritura Creativa, 80% en la electiva enfocada en el manejo del estrés y 94% en la electiva de Mapa de Sentidos; la coincidencia general fue de 66%. Al final se discute que, si bien es cierto las electivas están enfocadas de forma adecuada para conseguir una educación para la academia, también lo está para la vida. Es necesario establecer de forma previa y mesurable las habilidades a desarrollar en cada asignatura y de qué manera, con el fin de optimizar los resultados de aprendizaje y tener un impacto acorde a los objetivos de las asignaturas.
Los resultados mostraron un 66% de coincidencia entre los participantes llevando a la discusión de que, si bien es cierto que las electivas están enfocando de forma adecuada la educación para la vida y no únicamente para la academia, es necesario ajustar de forma previa y mesurable qué habilidades se desarrollan en cada asignatura y de qué manera, para optimizar los resultados de aprendizaje y tener un impacto acorde a los objetivos de las asignaturas.
Blocking effect of Guan-Fu Base A on human Na V 1.5 channels and the mutants expressed in Xenopus Laevis oocytes
Authors: Wang Na , Fan Xin-Rong , Wen Jing , Zeng Bo , Chen Gui-Lan 
Published: July 2022

Introduction GFA (Guan-Fu Base A) as one of the main active
substances in the Chinese medicine Ranunculaceae Aconite, has been
approved the effect of anti-atrial fibrillation via its atrial-selective
Na channel-blocking action. It is recently
undergoing phase IV clinical study. However, the molecular mechanism of
Na 1.5 channel inhibition by GFA is largely unclear.
Methods and Results Na 1.5 channel and its
mutants were expressed in Xenopus oocytes and the currents were
recorded with two-microelectrode voltage-clamp. GFA inhibited Na
1.5 currents in a concentration-dependent manner, with
IC of 66.24 μM, 371.59 μM, and 381.08 μM for
wild type (WT), Delta KPQ (∆KPQ) and R1623Q constructs, respectively.
Both the mutations of ∆KPQ and R1623Q decreased inhibitory potency of
GFA about 5~6-fold. N406K mutation significantly altered
the inhibition effect of GFA. Even 1 mM GFA has almost no inhibitory
effect on the mutant. For both the WT and mutant channels, GFA reduced
the currents in concentration, voltage and time dependent manner.
Conclusion: GFA is a potent blocker of Na 1.5
channel. N406, the aromatic residues in the transmembrane helical of
DIS6, is most likely responsible for the high-affinity binding of GFA to
Na 1.5 channel.
PATAS, a first-in-class therapeutic peptide biologic, improves whole-body insulin resistance and associated comorbidities in vivo
Authors: Schreyer Edwige , Obringer Cathy , Messaddeq Nadia , Kieffer Bruno , Zimmet Paul , Fleming Alexander , Geberhiwot Tarekegn , Marion Vincent 
Published: July 2022

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<p>Adipose tissue is a key regulator of whole-body metabolic fitness because of its role in controlling insulin sensitivity. Obesity is associated with hypertrophic adipocytes with impaired glucose absorption; a phenomenon existing in the ultra-rare monogenic disorder Alström syndrome consisting of severe insulin resistance. Inactivation of ALMS1 directly inhibits insulin-mediated glucose absorption in the white adipose tissue and induces severe insulin resistance, which leads to type 2 diabetes, accelerated non-alcoholic liver disease and fibrosis. These phenotypes were reversed by specific adipocyte-ALMS1 reactivation <em>in vivo</em>. Subsequently, ALMS1 was found to bind to PKC alpha in the adipocyte and upon insulin signaling PKC alpha is released from ALMS1. Alpha helices in the kinase domain of PKC alpha were therefore screened to identify a peptide sequence that interfered with the ALMS1-PKC alpha protein interaction. When incubated with cultured human adipocytes, the stapled peptide termed PATAS, for <strong>P</strong>eptide derived of PKC <strong>A</strong>lpha <strong>T</strong>argeting <strong>A</strong>lm<strong>S</strong>, triggered insulin-independent glucose absorption, <em>de novo</em> lipogenesis and cellular glucose utilization. <em>In vivo</em>, PATAS reduced whole-body insulin resistance, improved glucose intolerance, fasting glucose, liver steatosis and fibrosis in rodents. Thus, PATAS represents a novel first-in-class peptide that targets the adipocyte to ameliorate insulin resistance and its associated comorbidities. </p>
BAF60a deficiency in macrophage promotes diet-induced obesity and metabolic inflammation
Authors: Kong Qin , Zou Jiahuan , Zhang Ziyin , Pan Ran , Zhang Zhe Yu , Han Shuang , Xu Yanyong , Gao Yue , Meng Zhuo-Xian 
Published: July 2022

<p> </p>
<p>Adipose tissue macrophage (ATM) has been shown to play a key role in the pathogenesis of obesity-associated adipose tissue inflammation and metabolic diseases. However, the upstream factors that integrate the environmental signals to control ATM activation and adipose inflammation in obesity remain elusive. Here, we identify BAF60a, a subunit of the SWI/SNF chromatin remodeling complexes, as the central checkpoint regulator of obesity-induced ATM activation, adipose tissue inflammation and systemic metabolic impairment. BAF60a expression was robustly downregulated in the adipose tissue stromal vascular fractions (SVFs) in type 2 diabetic mice. Myeloid-specific BAF60a ablation (BaMKO) promotes ATM pro-inflammatory activation, exacerbating diet-induced obesity, insulin resistance and metabolic dysfunction. Conversely, myeloid-specific overexpression of BAF60a in mice attenuates macrophage pro-inflammatory activation. Mechanistically, transcriptome and chromatin landscape analyses demonstrate that BAF60a inactivation triggers the expression of pro-inflammatory gene program through chromatin remodeling. Moreover, motif analysis of ATAC-Seq and CUT&Tag-Seq data identifies the transcription factor Atf3 that physically interacts with BAF60a to suppress the pro-inflammatory gene expression, thereby controlling ATM activation and metabolic inflammation in obesity. Consistently, myeloid-specific Atf3 deficiency also promotes the pro-inflammatory activation of macrophage. Together, this work uncovers BAF60a/Atf3 axis as the key regulator in obesity-associated ATM activation, adipose tissue inflammation and metabolic diseases.</p>
PENGARUH KEPEMILIKAN KELUARGA TERHADAP KEBIJAKAN DIVIDEN (STUDI EMPIRIS PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2016-2018)
Authors: Siswantaya I Gede 
Published: July 2022

ABSTRACTThis research aims to examine the effect of family ownership on dividend policy, since in Indonesia most companies are family companies. The sample of this research is banking companies which published annual reports in the period of 2016-2018. In all, there are 29 companies and 87 observations. This research uses the data derived from the Indonesia Stock Exhange official website (www.idx.co.id). Hypothesis is tested by using multiple regression analysis, with Return on Assets (ROA) as the control variable. The results show that family ownership negatively affects dividend policy.Keywords: family ownership; dividend policy; return on assets; expropriationABSTRAKPenelitian ini bertujuan untuk menguji pengaruh perusahaan dengan kepemilikan keluarga atas kebijakan dividen yang akan diambil, hal tersebut dikarenakan Indonesia merupakan salah satu negara yang karakteristik perusahaannya merupakan perusahaan kepemilikan keluarga. Sampel dalam penelitian ini adalah perusahaan perbankan yang menerbitkan laporan tahunan 2016-2018. Berdasarkan kriteria yang ditetapkan, terdapat sampel 29 perusahaan perbankan dengan 87 pengamatan. Data penelitian diambil dari website resmi Bursa Efek Indonesia (www.idx.co.id). Pengujian hipotesis menggunakan analisis regresi linear berganda. Variabel kontrol yang digunakan dalam penelitian ini adalah Return on Assets (ROA). Hasil dari penelitian ini menunjukkan bahwa kepemilikan keluarga berpengaruh negatif terhadap kebijakan dividen. Kata kunci: kepemilikan keluarga; kebijakan dividen; return on assets; ekspropriasi
Desain Sistem Kerja yang Berpusat pada Manusia Transisi Ke Industri 4.0
Authors: Fandhilah Laisa Sofiana Nur , Giovanni Axel 
Published: July 2022

Saat ini transisi Industri 4.0 semakin meningkat untuk menerapan perubahan dalam pekerjaan manusia dan kerja organisasi, sehingga menciptakan tantangan dan peluang baru. Untuk memanfaatkan dan menghadapi tantangan ini, perlu adanya pemahaman tentang interaksi dan penerapan rancangan sistem kerja yang berpusat pada manusia terhadap teknologi baru. Dalam artikel ini, menyajikan temuan tinjauan pustaka tentang gambaran sistem kerja yang berpusat pada manusia dalam menghadapi transisi Industri 4.0 . Kata Kunci : Sistem kerja, Human-Centered, Industri 4.0
Pengaruh Pendapatan Asli Daerah, Dana Alokasi Umum dan Dana Alokasi Khusus Terhadap Belanja Modal
Authors: Ivana Diva , Hardiwinoto Hardiwinoto , Nurcahyono Nurcahyono 
Published: July 2022

Penelitian ini bertujuan untuk menguji pengaruh pendapatan asli daerah, dana alokasi umum dan dana alokasi khusus terhadap belanja modal. Jenis penelitian ini adalah penelitian kuantitatif. Sampel pada penelitian ini diperoleh dengan menggunakan metode purposive sampling, yaitu pemilihan sampel dengan kriteria – kriteria yang telah ditentukan. Berdasarkan metode purposive sampling tersebut didapatkan sebanyak 80 sampel dari 35 kabupaten/kota provinsi Jawa Tengah dan 5 kabupaten/kota di DIY Yogyakarta. Teknik analisis yang digunakan adalah regresi linear berganda. Hasil analisis data diketahui pengujian hipotesis secara parsial PAD berpengaruh positif dan signifikan terhadap belanja modal, Dana Alokasi Umum berpengaruh tidak signifikan terhadap belanja modal, Dana Alokasi Khusus berpengaruh positif dan signifikan terhadap belanja modal. secara simultan PAD, DAU, DAK berpengaruh positif dan signifikan terhadap belanja modal. Kata Kunci : Pendapatan Asli Daerah, Dana Alokasi Umum, Belanja Modal
The Religiosity Values in the Novel of the Split Moon in America Sky and its Relevance toward the Character Education Values
Authors: Wiryareja Sutarman Tarman , Aman Santoso Adina Pamungkas 
Published: July 2022

This study aims to examine in depth the values of religiosity in the novel “Bulan Terbelah di Langit di Amerika” (BTDLA) and its values of moral/character education contained of the novel.The method used in this research is a qualitative method with a literature review approach. This research is a library research, with the primary data source is the novel BTDLA by Hanum Salsabila Rais Rangga Almahendra, and the secondary data sources are books, articles relevant to religious values, and research journals related to the novel. The data was collected by using literary research techniques. The technique used in this study was critical reading and content analysis.The results of this study indicate that there are religious values in the BTDLA novel and its relevance to the values of character education (morals), namely: (1) there is a good relationship between humans and God, humans with humans, humans with the environment, and society; (2) the relationship between humans and God is good and also depends on how humans treat other humans; (3) Learn about the values of caring for others, respecting differences, and remaining peaceful and prosperous without any debate and upholding religious tolerance, without tarnishing one's own beliefs or those of others.
Persepsi Keamanan, Kepercayaan, dan Akuntabilitas Perusahaan Terhadap Niat Berdonasi Melalui Fintech Crowdfunding
Authors: Irawan Dwi , Puspitasari Arlita Ariyani , Astuti Sri Wibawani Wahyuning , Widyastuti Aviani 
Published: July 2022

ABSTRACTThis study aims to empirically examine the effect of perceived security, trust and corporate accountability on the intention to donate through fintech crowdfunding. This research data is primary data which is obtained by distributing questionnaires through google form. The population of this study is all Indonesian people who have used fintech crowdfunding. The sample in this study used simple random sampling, where everyone who has used fintech crowdfunding is randomly selected and asked to be part of the research sample. Testing the data in this study using structural equation modeling (SEM) model with a Smart PLS 3. The results showed that the trust, security and accountability of the company had a positive and significant effect on the intention to donate through fintech crowdfunding. A crowdfunding company that is able to provide a high level of security related to customer personal data and transaction information, is able to make customers believe it, and the company's ability to provide disclosure of its financial statement information will make people believe that they will make online donations to the crowdfunding company.Keywords: accountability, intention to donate, security, trust. ABSTRAKPenelitian ini bertujuan untuk menguji secara empiris pengaruh persepsi keamanan, kepercayaan dan akuntabilitas perusahaan terhadap niat berdonasi melalui fintech crowdfunding. Data penelitian ini merupakan data primer dimana diperoleh dengan melakukan penyebaran kuisioner melalui google form. Populasi penelitian ini seluruh masyarakat Indonesia yang pernah menggunakan fintech crowdfunding. Sampel pada penelitian ini menggunakan simple random sampling, dimana setiap orang yang pernah menggunakan fintech crowdfiunding dipilih secara acak dan diminta untuk menjadi bagian sebagai sampel penelitian. Pengujian data dalam penelitian ini menggunakan model structural equation modeling (SEM) dengan Smart PLS 3. Hasil penelitian menunjukkan bahwa kepercayaan, keamanan dan akuntabilitas perusahaan berpengaruh positif dan signifikan terhadap niat berdonasi melalui fintech crowdfunding. Perusaahan crowdfunding yang mampu memberikan tingkat keamanan yang tinggi terkait dengan data pribadi pelanggan maupun terhadap informasi transaksi, mampu membuat pelanggan pecaya, serta kemampuan perusahaan dalam memberikan keterbukaan atas informasi laporan keuangannya akan membuat masyarakat yakin akan melakukan donasi online pada perusahaan crowdfunding tersebut.Kata Kunci: akuntabilitas, keamanan, kepercayaan, niat berdonasi.
Analisis Determinan Kompetensi Pegawai Terhadap Implementasi New Public Service di Kabupaten Lamongan
Authors: Wulandari Devvy Pramasti 
Published: July 2022

ABSTRAKKompetensi pegawai merupakan faktor kunci dalam penyediaan layanan publik. Persoalan layanan publik yang lambat, tidak transparan dan diskriminatif merupakan sebagian indikator lemahnya kompetensi pegawai sektor publik di Indonesia. Penelitian ini bertujuan menguji pengaruh kompetensi pegawai terhadap implementasi New Public Service sebagai paradigma baru penyelenggaraan layanan publik di dunia. Sampel dipilih menggunakan metode purposive sampling dengan total 100 responden yang terebar di 10 instansi Pemerintah Kabupaten Lamongan. Dengan teknik analisis regresi linier berganda, penelitian ini meregresikan variabel independen character (X1), attitude (X2), knowledge (X3), skill (X4), dan motivation (X5) terhadap variabel dependen citizenship (Y1), accountability (Y2), dan Excellent Services (Y3) yang melalui uji instrumen dan uji asumsi klasik terlebih dahulu. Hasil penelitian ini membuktikan bahwa kompetensi pegawai berpengaruh secara simultan terhadap penerapan New Public Service dengan tingkat signifikan 0,000. Sedangkan secara parsial, implementasi prinsip citizenship dipengaruhi signifikan oleh attitude, knowledge, dan motivation. Implementasi prinsip accountability dipengaruhi signifikan oleh knowledge dan skill. Sedangkan, implementasi prinsip excellent service dipengaruhi signifikan oleh knowledge, skill, dan motivation. Melalui analisis adjusted R-square, kompetensi pegawai mempengaruhi implementasi New Public Service yaitu 87,7% mempengaruhi prinsip citizenship (R2 0,877), 77,4% mempengaruhi accountability (R2 0,774), dan 88,3% mempengaruhi excellent services (R2 0,883).Kata Kunci: Kompetensi Pegawai, New Public Service
SMART TROLLY DESIGN BASED ON MARKER DETECTION
Authors: Trisno Syahrul Nugraha , Ubaidillah Achmad , Wibisono Kunto Aji 
Published: July 2022

In this modern era, robots are very instrumental in helping the human work and even replace their work. From the various human works, humans will need a trolley to carry goods. As in supermarkets, people will need a trolley to make it easier to carry groceries and other luggage. But with a trolley that is commonly used, users must encourage the trolley to move so that it reduces hand activity to do other activities. Therefore, we need a trolley that can move to follow the user automatically, so the user no longer needs to push the trolley, and the user's hand can be more free to do other activities. This research discusses about trolley robot using marker detection. With the application of this method will help the robot determine the object so as to facilitate the movement of the robot to follow the user. In the testing process carried out in the study, the system accuracy in detecting markers on objects was 70%.