bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrospinning Nanofibrous Sodium Alginate/β‐Cyclodextrin Composite Membranes for Methylene Blue Adsorption
Authors: Ma Xiaolong , Men Jinxin , Gao Tong , Liu Wenxia , Wang Xuejun , Lou Tao 
Published: July 2022

AbstractTo effectively remove the toxic dyes from wastewater, sodium alginate (SA)/β‐cyclodextrin(β‐CD) nanofibrous composite membranes with average fiber diameters of 167–174 nm are obtained by an electrospinning method. The adsorption capacity of the SA/β‐CD membrane for methylene blue is 2776 mg g–1, much higher than that of a pure SA membrane (1780 mg g–1). The incorporation of β‐CD also improves the adsorption rate significantly. The adsorption mechanism is mainly the synergy of the electrostatic attraction of SA and the host–guest interaction of β‐CD. Meanwhile, the SA/β‐CD nanofibrous membranes can be used in a wide pH range, and maintain excellent adsorption capacity after four cycles. The rapid adsorption efficiency and excellent adsorption capacity of SA/β‐CD nanofibrous membrane endows great potential in the field of wastewater treatment.
Preclinical evaluation of [18F]FDG-PET as a biomarker of lymphoid tissue disease and inflammation in Zika virus infection
Authors: Victorio Carla Bianca Luena , Ong Joanne , Tham Jing Yang , Reolo Marie Jennifer , Novera Wisna , Msallam Rasha , Watanabe Satoru , Kalimuddin Shirin , Low Jenny G. , Vasudevan Subhash G. , Chacko Ann-Marie 
Published: July 2022

Abstract

Purpose
Zika (ZIKV) is a viral inflammatory disease affecting adults, children, and developing fetuses. It is endemic to tropical and sub-tropical countries, resulting in half the global population at risk of infection. Despite this, there are no approved therapies or vaccines against ZIKV disease. Non-invasive imaging biomarkers are potentially valuable tools for studying viral pathogenesis, prognosticating host response to disease, and evaluating in vivo efficacy of experimental therapeutic interventions. In this study, we evaluated [18F]fluorodeoxyglucose ([18F]FDG)-positron emission tomography (PET) as an imaging biomarker of ZIKV disease in a mouse model and correlated metabolic tracer tissue uptake with real-time biochemical, virological, and inflammatory features of tissue infection.

Methods
[18F]FDG-PET/CT imaging was performed in an acute, lethal ZIKV mouse infection model, at increasing stages of disease severity. [18F]FDG-PET findings were corroborated with ex vivo wholemount-tissue autoradiography and tracer biodistribution studies. Tracer uptake was also correlated with in situ tissue disease status, including viral burden and inflammatory response. Immune profiling of the spleen by flow cytometry was performed to identify the immune cell subsets driving tissue pathology and enhancing tracer uptake in ZIKV disease.

Results
Foci of increased [18F]FDG uptake were consistently detected in lymphoid tissues—particularly the spleen—of ZIKV-infected animals. Splenic uptake increased with disease severity, and corroborated findings in tissue pathology. Increased splenic uptake also correlated with increased viral replication and elevated expression of pro-inflammatory cytokines within these tissues. ZIKV-infected spleens were characterized by increased infiltration of myeloid cells, as well as increased proliferation of both myeloid and lymphoid cells. The increased cell proliferation correlated with increased tracer uptake in the spleen. Our findings support the use of [18F]FDG as an imaging biomarker to detect and track ZIKV disease in real time and highlight the dependency of affected tissue on the nature of the viral infection.

Conclusion
[18F]FDG uptake in the spleen is a useful surrogate for interrogating in situ tissue viral burden and inflammation status in this ZIKV murine model.
EARL compliance and imaging optimisation on the Biograph Vision Quadra PET/CT using phantom and clinical data
Authors: van Sluis Joyce , van Snick Johannes H. , Brouwers Adrienne H. , Noordzij Walter , Dierckx Rudi A. J. O. , Borra Ronald J. H. , Slart Riemer H. J. A. , Lammertsma Adriaan A. , Glaudemans Andor W. J. M. , Boellaard Ronald , Tsoumpas Charalampos 
Published: July 2022

Abstract
Purpose
Current European Association of Nuclear Medicine (EANM) Research Ltd. (EARL) guidelines for the standardisation of PET imaging developed for conventional systems have not yet been adjusted for long axial field-of-view (LAFOV) systems. In order to use the LAFOV Siemens Biograph Vision Quadra PET/CT (Siemens Healthineers, Knoxville, TN, USA) in multicentre research and harmonised clinical use, compliance to EARL specifications for 18F-FDG tumour imaging was explored in the current study. Additional tests at various locations throughout the LAFOV and the use of shorter scan durations were included. Furthermore, clinical data were collected to further explore and validate the effects of reducing scan duration on semi-quantitative PET image biomarker accuracy and precision when using EARL-compliant reconstruction settings.

Methods
EARL compliance phantom measurements were performed using the NEMA image quality phantom both in the centre and at various locations throughout the LAFOV. PET data (maximum ring difference (MRD) = 85) were reconstructed using various reconstruction parameters and reprocessed to obtain images at shorter scan durations. Maximum, mean and peak activity concentration recovery coefficients (RC) were obtained for each sphere and compared to EARL standards specifications.
Additionally, PET data (MRD = 85) of 10 oncological patients were acquired and reconstructed using various reconstruction settings and reprocessed from 10 min listmode acquisition into shorter scan durations. Per dataset, SUVs were derived from tumour lesions and healthy tissues. ANOVA repeated measures were performed to explore differences in lesion SUVmax and SUVpeak. Wilcoxon signed-rank tests were performed to evaluate differences in background SUVpeak and SUVmean between scan durations. The coefficient of variation (COV) was calculated to characterise noise.

Results
Phantom measurements showed EARL compliance for all positions throughout the LAFOV for all scan durations. Regarding patient data, EARL-compliant images showed no clinically meaningful significant differences in lesion SUVmax and SUVpeak or background SUVmean and SUVpeak between scan durations. Here, COV only varied slightly.

Conclusion
Images obtained using the Vision Quadra PET/CT comply with EARL specifications. Scan duration and/or activity administration can be reduced up to a factor tenfold without the interference of increased noise.
Clinical and sociodemographic determinants of disease-specific health-related quality of life in long-term breast cancer survivors
Authors: Doege Daniela , Thong Melissa S. Y. , Koch-Gallenkamp Lena , Bertram Heike , Eberle Andrea , Holleczek Bernd , Nennecke Alice , Pritzkuleit Ron , Waldmann Annika , Zeissig Sylke R. , Brenner Hermann , Arndt Volker 
Published: July 2022

Abstract
Purpose
It is important to monitor disease-specific health-related quality of life (HRQoL) in breast cancer (BC) survivors to identify potential unmet supportive care needs. However, previous studies were characterized by small samples of mostly short-term survivors and were limited to certain age ranges, stages and/or treatments.

Methods
We used data from 3045 long-term BC survivors (5–15 years post-diagnosis) recruited in a German multi-regional population-based study. We assessed disease-specific HRQoL with the EORTC QLQ-BR23, scoring from 0 to 100. Differences in functioning and symptoms according to age at survey, self-reported treatments, stage, and disease status (disease-free vs. active disease) were assessed with multiple regression. Active disease was defined as any self-report of recurrence, metastasis or second primary cancer after the index cancer.

Results
Older BC survivors reported a higher body image and a better future perspective, but lower sexual functioning. Survivors aged 30–49 years who had breast-conserving therapy or mastectomy with breast reconstruction reported a better body image compared to those who had mastectomy only. We also found differences in symptoms according to treatments in some age groups. Stage at diagnosis was not associated with HRQoL overall and in most age subgroups. Disease-free BC survivors aged 30–79 years reported a better future perspective and less systemic therapy side effects than those with active disease.

Conclusion
Several treatment-associated symptoms and functioning detriments were found 5–15 years after diagnosis. The results emphasize the need of a comprehensive, individualized survivorship care, recognizing differential needs of long-term BC survivors according to age, treatment modalities, and disease status.
Reverse spatial top-k keyword queries
Authors: Ahmed Pritom , Eldawy Ahmed , Hristidis Vagelis , Tsotras Vassilis J. 
Published: July 2022

AbstractWe introduce the ReverseSpatial Top-kKeyword (RSK) query, which is defined as: given a query term q, an integer k and a neighborhood size find all the neighborhoods of that size where q is in the top-k most frequent terms among the social posts in those neighborhoods. An obvious approach would be to partition the dataset with a uniform grid structure of a given cell size and identify the cells where this term is in the top-k most frequent keywords. However, this answer would be incomplete since it only checks for neighborhoods that are perfectly aligned with the grid. Furthermore, for every neighborhood (square) that is an answer, we can define infinitely more result neighborhoods by minimally shifting the square without including more posts in it. To address that, we need to identify contiguous regions where any point in the region can be the center of a neighborhood that satisfies the query. We propose an algorithm to efficiently answer an RSK query using an index structure consisting of a uniform grid augmented by materialized lists of term frequencies. We apply various optimizations that drastically improve query latency against baseline approaches. We also provide a theoretical model to choose the optimal cell size for the index to minimize query latency. We further examine a restricted version of the problem (RSKR) that limits the scope of the answer and propose efficient approximate algorithms. Finally, we examine how parallelism can improve performance by balancing the workload using a smart load slicing technique. Extensive experimental performance evaluation of the proposed methods using real Twitter datasets and crime report datasets, shows the efficiency of our optimizations and the accuracy of the proposed theoretical model.
Blockchain Technology for Supply Chains operating in emerging markets: an empirical examination of technology-organization-environment (TOE) framework
Authors: Chittipaka Venkataiah , Kumar Satish , Sivarajah Uthayasankar , Bowden Jana Lay-Hwa , Baral Manish Mohan 
Published: July 2022

AbstractOrganizations adopt blockchain technologies to provide solutions that deliver transparency, traceability, trust, and security to their stakeholders. In a novel contribution to the literature, this study adopts the technology-organization-environment (TOE) framework to examine the technological, organizational, and environmental dimensions for adopting blockchain technology in supply chains. This represents a departure from prior studies which have adopted the technology acceptance model (TAM), technology readiness index (TRI), theory of planned behavior (TPB), united theory of acceptance and use of technology (UTAUT) models. Data was collected through a survey of 525 supply chain management professionals in India. The research model was tested using structural equation modeling. The results show that all the eleven TOE constructs, including relative advantage, trust, compatibility, security, firm’s IT resources, higher authority support, firm size, monetary resources, rivalry pressure, business partner pressure, and regulatory pressure, had a significant influence on the decision of blockchain technology adoption in Indian supply chains. The findings of this study reveal that the role of blockchain technology adoption in supply chains may significantly improve firm performance improving transparency, trust and security for stakeholders within the supply chain. Further, this research framework contributes to the theoretical advancement of the existing body of knowledge in blockchain technology adoption studies.
Interactions Between Flame Topology and Turbulent Transport in High-Pressure Premixed Combustion
Authors: Martínez-Sanchis Daniel , Sternin Andrej , Tagscherer Kenneth , Sternin Daniel , Haidn Oskar , Tajmar Martin 
Published: July 2022

AbstractDirect numerical simulations of a turbulent premixed stoichiometric methane-oxygen flame were conducted. The chosen combustion pressure was 20 bar, to resemble conditions encountered in modern rocket combustors. The chemical reactions followed finite rate detailed mechanism integrated into the EBI-DNS solver within the OpenFOAM framework. Flame geometry was thoroughly investigated to assess its interaction with the transport of turbulent properties. The resulting flame front was remarkably thin, with high density gradients and moderate Karlovitz and Damköhler numbers. At mid-flame positions, the variable-density transport mechanisms dominated, leading to the generation of both vorticity and turbulence. A reversion of this trend towards the products was observed. For intermediate combustion progress, vorticity transport is essentially a competition between the baroclinic torque and vortex dilatation. The growth of turbulent kinetic energy is strongly correlated to this process. A geometrical analysis reveals that the generation of enstrophy and turbulence is restricted to specific topologies. Convergent and divergent flame propagation promote turbulence creation due to pressure fluctuation gradients through different physical processes. The possibility of modeling turbulence transport based on curvature is discussed along with the inherent challenges.
Stabilisation of soil organic matter: interactions between clay and microbes
Authors: Islam Md. Rumainul , Singh Balwant , Dijkstra Feike A. 
Published: July 2022

AbstractSoil organic matter (SOM) plays a central role in the global carbon balance and in mitigating climate change. It will therefore be important to understand mechanisms of SOM decomposition and stabilisation. SOM stabilisation is controlled by biotic factors, such as the efficiency by which microbes use and produce organic compounds varying in chemistry, but also by abiotic factors, such as adsorption of plant- and microbially-derived organic matter onto soil minerals. Indeed, the physicochemical adsorption of organic matter onto soil minerals, forming mineral associated organic matter (MAOM), is one of the significant processes for SOM stabilisation. We integrate existing frameworks of SOM stabilisation and illustrate how microbial control over SOM stabilisation interacts with soil minerals. In our new integrated framework, we emphasise the interplay between substrate characteristics and the abundance of active clay surfaces on microbial processes such as carbon use efficiency and recycling. We postulate that microbial use and recycling of plant- and microbially-derived substrates decline with increased abundance of active clay surfaces, and that the shape of these relationships depend on the affinity of each substrate to adsorb, thereby affecting the efficiency by which organic matter remains in the soil and is stabilised into MAOM. Our framework provides avenues for novel research and ideas to incorporate interactions between clay surfaces and microbes on SOM stabilisation in biogeochemical models.
Graphical abstract
Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats
Authors: Nawwar Dalia A. , Zaki Hala F. , Sayed Rabab H. 
Published: July 2022

AbstractSchizophrenia is a common mental disorder affecting patients’ thoughts, behavior, and cognition. Recently, the NRG1/ErbB4 signaling pathway emerged as a candidate therapeutic target for schizophrenia. This study investigates the effects of aripiprazole and sertindole on the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in ketamine-induced schizophrenia in rats. Young male Wistar rats received ketamine (30 mg/kg, intraperitoneally) for 5 consecutive days and aripiprazole (3 mg/kg, orally) or sertindole (2.5 mg/kg, orally) for 14 days. The proposed pathway was investigated by injecting LY294002 (a selective PI3K inhibitor) (25 μg/kg, intrahippocampal injection) 30 min before the drugs. Twenty-four hours after the last injection, animals were subjected to behavioral tests: the open field test, sucrose preference test, novel object recognition task, and social interaction test. Both aripiprazole and sertindole significantly ameliorated ketamine-induced schizophrenic-like behavior, as expected, because of their previously demonstrated antipsychotic activity. Besides, both drugs alleviated ketamine-induced oxidative stress and neurotransmitter level changes in the hippocampus. They also increased the gamma-aminobutyric acid and glutamate levels and glutamate decarboxylase 67 and parvalbumin mRNA expression in the hippocampus. Moreover, aripiprazole and sertindole increased the NRG1 and ErbB4 mRNA expression levels and PI3K, p-Akt, and mTOR protein expression levels. Interestingly, pre-injecting LY294002 abolished all the effects of the drugs. This study reveals that the antipsychotic effects of aripiprazole and sertindole are partly due to oxidative stress reduction as well as NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways activation. The NRG1/ErbB4 and PI3K signaling pathways may offer a new therapeutic approach for treating schizophrenia in humans.
Exploring the Association Between Irrational Beliefs, Motivation Regulation and Anxiety in Ultra-Marathon Runners: A Mixed Methods Approach
Authors: Miller Anthony , Calder Bruce , Turner Martin , Wood Andrew 
Published: July 2022

AbstractResearchers are beginning to explore the antecedents to anxiety symptomology. Such antecedents to anxiety symptomology may be that of irrational beliefs and motivation regulation. It has been intimated that both irrational beliefs and motivation regulation can be risk factors for increased anxiety in athletes. Research is yet to explore the association between these two antecedents, and how and whether they interact in predicting anxiety symptomology. The present paper investigates such associations within two phases. In phase one, we identify the predictive capacity of irrational beliefs and motivation regulation on anxiety symptomology in 61 elite ultra-marathon runners. Results support intimated associations between irrational beliefs and motivation regulation, evidencing that irrational performance beliefs negatively associated with relative autonomous motivation. In addition, it was found that irrational performance beliefs positively associated with anxiety symptomology, whilst autonomous motivation negatively associated with anxiety symptomology in elite ultra-marathon runners. In phase two, we use a narrative approach to understand seven elite athletes’ stories surrounding their performance beliefs, motivation, and anxiety symptomology. Phase two supports findings in phase one, evidencing that the co-existence of both irrational performance beliefs and controlled motivation is an antecedent to anxiety symptomology and dysfunctional behaviours in ultra-marathon runners. The findings of both phase one and phase two are discussed in relation to the theoretical and practical implications for elite athletes.
Global justice in the context of transnational surrogacy: an African bioethical perspective
Authors: Fayemi Ademola Kazeem , Chimakonam Amara Esther 
Published: July 2022

AbstractThe ongoing debate on how best to regulate international commercial surrogacy defies consensus, as the most cogent normative and jurisprudential grounds for and against non-altruistic surrogacy remain controversial. This paper contributes to the debate by focusing on social justice issues arising from transnational, moneymaking surrogacy, with a focus on the Global South. It argues that existing theoretical perspectives on balancing interests, rights, privileges, and resources in the context of cross-border surrogacy—such as cosmopolitanism, communitarianism, liberal feminism, radical feminism, and neorealism—are not sufficient to treat the question of justice underpinning transnational surrogacy in the Global South. An Afro-communal theory of social justice is proposed as an alternative model for addressing the shortcomings in existing global justice theories. Building on Thaddeus Metz’s construction of Afro-communal social theory and a bioethic of communion, this article reveals the fundamental nature of injustices in the Global South surrogacy foray. This approach provides prima facie grounds for making commercial surrogacy more just in the evolving global order.
The role of parental health and distress in assessing children’s health status
Authors: Kaplan Sherrie H. , Shaughnessy Marilou , Fortier Michelle A. , Vivero-Montemayor Marla , Masague Sergio Gago , Hayes Dylan , Stern Hal , Dai Maozhu , Heim Lauren , Kain Zeev 
Published: July 2022

Abstract
Purpose
The purpose of the study was to examine the contributions of parents’ health and distress to parent’s and children’s assessments of children’s health.

Methods
We used baseline data from a longitudinal study of 364 children (ages 4–12) about to undergo surgery and their parents in a Southern California pediatric hospital. We used the 20-item child self-reported CHRIS 2.0 general health and the parallel parent-reported measure of the child’s health, along with a measure of parental distress about the child’s health were administered in the perioperative period. Other measures included parents’ physical and mental health, quality of life, distress over their child’s health, and number and extent of other health problems of the child and siblings.

Results
On average, parents’ reports about the child were consistently and statistically significantly higher than children’s self-reports across all sub-dimensions of the CHRIS 2.0 measure. Parents’ personal health was positively associated with their reports of the child’s health. More distressed parents were closer to the child’s self-reports, but reported poorer personal health.

Conclusion
Parent–child differences in this study of young children’s health were related to parental distress. Exploring the nature of the gap between parents and children in assessments of children’s health could improve effective clinical management for the child and enhance family-centered pediatric care. Future studies are needed to assess the generalizability of CHRIS 2.0 to other health settings and conditions and to other racial/ethnic groups.