bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Unicortical Locking Screw Placement Effective For The Torsional Loads in the Distal Radius Fractures? : Biomechanical Study in Cadaver
Authors: Pehlivan Ali Tufan , Oc Yunus , Ertogrul Rodi , KILINC BEKIR ERAY 
Published: June 2022

Abstract
Background
We aimed to compare biomechanical outcomes of short-length (75%-length) and full-length (100%-length) unicortical distal screws under axial and torsional compression in cadaveric distal radius volar plate model.
Methods
A total of 20 wrists from 10 fresh frozen cadavers were included. 2.5 mm titanium alloy distal radius anatomical plates was placed to the distal radii in full anatomical position, just proximal to the watershed line. Three bicortical screws to the shaft of the radius, followed by unicortical drilling for distal screwing were placed. Measurement by pulling the drill once it reached the opposite cortex was applied. We selected the screw lengths such that they corresponded to the 75% of the measured length (short-length). In the same configuration for each of the cadavers, we delivered six screws from distal radius holes of the anatomical plate. oscillating handsaw was used to create extraarticular distal radius fracture model (AO 23-A3.2). We created dorsal AP model by performing a 1-cm wedge osteotomy from dorsal aspect. Complete separation of the volar cortex was achieved. Potting was performed by embedding the shaft of the prepared radius into the polyurethane medium. We placed aluminum apparatus into the distal end to ensure applying of torsional and axial loading in biomechanistic tests.
Results
No statistically significant difference of stiffness between the short-length and full-length distal screws both under axial compression(p = 0.88) and torsional compression (p = 0.82). Short-length and full-length distal screw groups did not differ in elastic limit under axial compression (p = 0.71) and torsional compression (p = 0.71). Maximal force on short-length and full-length distal screw groups were also similar under both axial compression (p = 0.71) and torsional compression (p = 0.50).
Conclusion
It is a safe method under torsional load to avoid drilling of the dorsal cortex and unicortical delivery of 75%-length distal screws could be performed in order to prevent from extensor tendon complications secondary to drilling or screw protrusion.
Spatio-temporal variation of major ion chemistry and nutrient stoichiometry in a tropical monsoonal estuary: Insight into biogeochemical processes
Authors: Akhtar Shaheen , Equeen Sk. Md. 
Published: June 2022

Abstract
Major ions and nutrient chemistry of surface water from the Devi river estuary, eastern India has been studied in order to understand the governing biogeochemical processes. Concentration of Na, K, Ca, Mg, Cl, SO4 and PO4 increases towards higher salinity; however, NO3 and dissolved silica (DSi) decreases from upper to lower estuary. All major ions, except NO3 and DSi, show the highest and lowest concentration in summer and monsoon season respectively. Increased surface runoff has resulted in the highest concentration of NO3 and DSi in the monsoon period. The Na, Cl, SO4, NO3 and PO4 ions show conservative mixing behavior in the estuary throughout the year. Non-conservative behavior of DSi is attributed to the combined process of mineral weathering and biological removal by diatoms. Enrichment and depletion of Ca and Mg in the estuary is owed to carbonate mineral precipitation and dissolution processes. Decreasing carbonate saturation indices (SI) with reducing pH accompanied by lowering of DO% suggests the influence of organic matter degradation on the carbonate precipitation and/or dissolution potential. Nutrient stoichiometric ratios – NO3:PO4, DSi:PO4 and DSi:NO3 – are found to vary spatially and seasonally as a result of differences in geochemical processes prevailing in the fresh- and marine-water environment. A prominent PO4 limitation is observed in the upper estuary during summer and winter. However, this limitation reduces towards the lower estuary owing to precipitation of Fe-sulphide under the influence of higher salinity. In contrast, the influx of PO4-limited freshwater into the estuary controls the nutrient limitation in the monsoon season. The spatial variation of chlorophyll concentration in the estuary is in accordance to the nutrient stoichiometric ratios. Thus, this study emphasizes on the role of unique biogeochemical processes in controlling the spatial and seasonal distribution of major ions and nutrient stoichiometry in a tropical estuarine system.
Endoscopic grading system for predicting anastomotic complications after esophagectomy: a prospective cohort study. (Endoscopic grading system after esophagectomy)
Authors: Kobayashi Shinichiro , Kanetaka Kengo , Yoneda Akira , Yamaguchi Naoyuki , Kobayashi Kazuma , Nagata Yasuhiro , Maruya Yasuhiro , Yamaguchi Shun , Hidaka Masaaki , Eguchi Susumu 
Published: June 2022

Abstract
BackgroundPostoperative complications related to gastric conduit reconstruction are still common issues after McKeown esophagectomy. A novel endoscopic grading system is desired to predict anastomotic complications after McKeown esophagectomy.Aims and MethodsThe purpose of this study was prospectively to evaluate the safety and efficacy of endoscopic examinations of the anastomotic region in the acute period after esophagectomy.Endoscopic examinations were performed on postoperative days (PODs) 1 and 8. The severity of the ischemic area was prospectively validated and classified into four categories according to the novel endoscopic mucosal ischemic grading system (EMIGS). ResultsFifteen patients (25.9%) developed anastomotic complications after esophagectomy. The negative predictive values for anastomotic complications, leakage, and strictures in EMIGS grades C or D were extremely high on POD 8 after esophagectomy (95.1%, 100%, and 95.1%, respectively). In the multivariate analysis, EMIGS grades C or D on POD 8 had a significant correlation with anastomotic complications after esophagectomy (odds ratio [OR]: 67.0; 95% confidence interval [CI]: 6.5-688.4; P < 0.01). EMIGS grades C or D on POD 8 after esophagectomy were associated with developing anastomotic leakage and strictures after esophagectomy in the univariate logistic regressions analysis (OR: 2.1 x 107; 95%CI:9.0 – infinity; P<0.01, OR:35.8; 95%CI:7.5 – 273.4; P<0.01, respectively). ConclusionsThe application of endoscopic classification to mucosal ischemia after McKeown esophagectomy yielded suboptimal accuracy in predicting anastomotic complications.Trial registration: Clinical Trial.gov Registry, ID: NCT02937389, Registration date: Oct 17, 2015
Resolution enhancement using a multi-layered Aluminum- based plasmonic device for chikungunya virus detection
Authors: Shukla Sambhavi , Grover Nitika , Arora Pankaj 
Published: June 2022

Abstract
Biomolecular variations can be accounted for by changes in the intrinsic properties of the surrounding medium, such as the refractive index. This work employs such an arrangement using a modified attenuated total internal reflection configuration for telecommunication wavelength (1550nm). The phenomenon of surface plasmon resonance is initiated by Aluminum (Al) metal due to its low cost and better compatibility with CMOS devices. To achieve improved plasmonic response in terms of the sensor’s resolution, we have explored metal-dielectric-metal configuration under angle interrogation. Barium titanate and Molybdenum disulfide (MoS2) have been employed as the high dielectric constant material and the binding media respectively to enhance the sensing performance. After a series of optimizations, the proposed device configuration leads to a maximum Figure of Merit (FOM) of 540.9 RIU− 1, thus enhancing the resolution. The proposed plasmonic device can be used for chikungunya virus detection by considering different blood components in normal and infected stages. This Al-based multi-layered plasmonic device can serve many applications for resolution enhancement in the near-infrared region.
M5C modulator mediated methylation pattern and TME cell infiltration in bladder cancer
Authors: Yang Zhan , Lang Zhichao , Tao Qiqi , Chen Bo , Li Xiaoqi , Zhan Yating , Zhang Rongrong , Zhu Kai , Yao Zhengze , Gao Yuxiang , Chen Ji , Zheng Jianjian , Li Yeping 
Published: June 2022

Abstract
Background:
In recent studies, the role of modification patterns of N6-methyladenosine (m6A) regulators in tumor microenvironment (TME) cell infiltration in the tumor microenvironment has been identified. However, the role of 5-methylcytosine (m5C) modification patterns in TME cell infiltration remains to be discovered.
Methods:
In this study, 660 bladder cancer patients were enrolled to comprehensively evaluate the m5C modification pattern based on 13 m5C regulators, and to explore the association between m5C modification pattern and TME cell infiltration status. Finally, PRINCIPAL component analysis (PCA) algorithm constructed m5Cscore, which was used to evaluate and quantify individual m5C modification patterns.
Results:
Our study identified three distinct m5C modification patterns in bladder cancer. Studies showed that TME cell infiltration characteristics under these three modification patterns were highly associated with three tumor immunophenotypes (immune-inflamed, immune-excluded, immune-desert). In addition, m5C methylation modification patterns were proved to be able to predict tumor disease progression, genetic variation and prognosis of patients. The individualized scoring system – m5Cscore, which was based on m5C methylation modification, showed great differences in tumor mutation burden (TMB), clinical characteristics, immune checkpoint and immunotherapy. The low m5Cscore group was characterized by matrix activation and lack of effective immune cell infiltration, indicating the immune-excluded phenotype. The higher m5Cscore group showed fewer PD-L1 mutations, which were associated with a promoted response to PD-L1/PD-1 immunotherapy and a better prognosis.
Conclusions:
This work confirmed the extensive regulatory mechanisms of the m5C modification pattern in the tumor microenvironment. The m5C modification pattern functioned as an important element of forming the heterogeneity and complexity of TME landscape. Understanding and in-depth evaluation of individual m5C modification patterns would help us understand the TME landscape and guide better immunotherapy strategies.
Pituitary Function at Presentation and Following Therapy in Patients with Non-functional Pituitary Adenomas: A Single Centre Retrospective Cohort Study
Authors: Hussein Ziad , Marcus Hani J , Grieve Joan , Dorward Neil , Kosmin Michael , Fersht Naomi , Bouloux Pierre Marc , Jaunmuktane Zane , Baldeweg Stephanie E 
Published: June 2022

Abstract
Background:Non-functioning pituitary macroadenomas (NFPMs) may present with hypopituitarism. Pituitary surgery and radiotherapy pose an additional risk to pituitary function.ObjectivesTo assess the incidence of hypopituitarism at presentation, the impact of treatment, and the likelihood of endocrine recovery during follow-up.MethodsAll patients treated surgically with and without radiotherapy for NFPMs between 1987 and 2018 who had longer than 6 months follow-up were identified. Demographics, presentation, investigation, treatment, and outcomes were collected.ResultsIn total, 383 patients were identified. The median age was 57 years with a median follow-up of 8 years. Preoperatively, 235 patients (235/377; 62%) had evidence of at least one pituitary deficiency. Anterior panhypopituitarism was more common in men (p =0.001), older patients (p =0.005), and in those with adenomas extending beyond the sella turcica (p =0.05). Patients treated with surgery and radiotherapy had a higher incidence of all individual pituitary hormone deficiency and anterior panhypopituitarism as well as significantly lower GH, ACTH, and TSH deficiencies free survival probability than those treated with surgery alone. Recovery of central hypogonadism, hypothyroidism, and anterior panhypopituitarism was also less likely to be reported in those treated with surgery and radiotherapy.ConclusionNFPMs are associated with significant degree of hypopituitarism at time of diagnosis and post therapy. The combination of surgery and radiotherapy is associated with higher risk of pituitary dysfunction. Recovery of pituitary hormone deficit may occur after surgical treatment. Patients should have regular ongoing endocrine evaluation post-treatment to assess changes in pituitary function and the need for long-term replacement therapy.
Pollution, Ecological, and Health Risk Assessments of Heavy Metal Remediated Soil by Compost Fortified with Natural Coagulants
Authors: Taiwo Adewale M. , Oladotun Oluwafunbi R. , Alegbeleye Wilfred O , Gbadebo Adewole M. 
Published: June 2022

Abstract
The present study assessed the pollution, ecological, and health risks of heavy metals (HMs) in remediated soils by compost fortified with natural coagulants (Moringa, Neem, and Pawpaw).The polluted soils were mixed with the stabilized composts at varying ratios of 1:200, 1:100, 1:66, and 1:50. Heavy metals(Cu, Zn, Ni, Mn, Cd, and Pb) were determined in compost and soil samples using Atomic Absorption Spectrophotometry. Data collected were analyzed for descriptive and inferential statistics. Removal efficiencies (REs) of HMs by the compost types were also determined. Results showed Mn as the highest observed HM in composts with values ranging from 179.6 ± 1.25 mg kg− 1 in Neem to 206.3 ± 5.01 mg kg− 1 in Moringa. The levels of HMs (except Zn) observed in composts were generally less than the target values expected in unpolluted soil. Application of the three composts to contaminated soils reduced the HMs by 5–37, 17–47, 25–43, 43–57,59–71, and 69–75% for Cd, Cu, Ni, Pb, Mn, and Zn, respectively. Removal of HMs in contaminated soils followed the distribution pattern of Zn > Mn > Pb > Cu > Ni > Cd. All the compost types were effective in cleaning up Mn and Zn in contaminated soils. However, Moringa appeared to indicate the highest removal efficiency followed by Neem and Pawpaw, in that order.
An advance of optimization by Simulated Annealing Algorithm and ANFIS to minimize delamination during drilling Chopped Strand Mat GFRP
Authors: Thangavel Panneerselvam , Sriniva Raghuraman , Vasu Manoj , Panneerselvam Monica 
Published: June 2022

Abstract
Glass Fibre Reinforced Polymer (GFRP) composites are commonly used in many applications, such as in the aerospace, construction, maritime and automotive sectors, owing to their lightweight, corrosion resistant, strong rigidity and lightweight to strength ratios. This form of material normally struggles on machining with surface delamination, fibre peeling up, fibre pulling away, fibre cracking, fibre de-bonding and fibre breaking. There is a need to optimize the drilling parameters specifically in reducing the type of damage known as delamination which is prevalent during drilling activity on Chopped Strand Mat GFRP material. Regression equations for the experimental results collected from drilling Chopped Strand Mat GFRP material are established for this purpose. Considering the established regression equations as objective functions, under parallel search methodology, Simulated Annealing Algorithm employs innovatively to refine the drilling parameters for reduced delamination. Simulated Annealing Algorithm (SAA) is programmed using C + + and the decrement factor, known as the cooling factor applied during the search process, is varied for the parallel search of optimization. Through this optimization strategy, the tailored drilling parameters for drilling Chopped Strand Mat GFRP material with minimal delamination are substantially enhanced, and the performance of SAA are verified by the Adaptive Neuro Fuzzy Inference System (ANFIS).
Prevalence and Associations of Asteroid Hyalosis: The Beijing Eye Study
Authors: Zhang Chuan , Shao Lei , Dong Li , Zhou Wen Da , Zhang Rui Heng , Wei Wen Bin 
Published: June 2022

Abstract
Background: To determine the prevalence and associations of asteroid hyalosis (AH) in a Chinese population-based cohort.Methods: The retrospective, cross-sectional, population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years (range: 50-93 years). Participants underwent detailed ophthalmic examinations including fundus photographs for diagnosis of AH. Data on systemic and ocular factors were collected for all participants according to the standardized protocol. Multiple linear regression and multivariate Logistic regression analysis were performed.Results: Fundus photographs were gradable in 3419 subjects. AH was detected in 63 (0.9%, 95% CI: 0.7%, 1.1%) eyes of 53 (1.6%, 95% CI: 1.1%, 2.0%) subjects. AH was bilateral in 18.9%. Mean age of all subjects with AH was 69.2± 9.5 years (median, 71.0 years; range, 51–91 years), mean spherical equivalent was 0.63±1.53D (median, 0.75 D; range, -4.12 to 4.00D). In multivariate analysis, prevalence of AH was associated with elder age (P=0.014, OR 1.057), thicker lens (P=0.032, OR 3.887), higher spherical equivalent (P=0.017, OR 1.396).Conclusions: In adult Chinese in Beijing, the prevalence of AH was 0.9% for eyes or 1.6% for subjects. AH was associated with elder age, thicker lens, and higher spherical equivalent. It was not associated with diabetes or other systemic indicators.
Die Kennzeichnungskraft von Akronymen und eine potenzielle stillschweigende Praxisänderung bei der vollständigen Übernahme des älteren Zeichens in die neuere Marke
Authors: Reber Yannick 
Published: June 2022

Das Bundesverwaltungsgericht hatte sich anlässlich des Urteils B-1306/2021 vom 1. Februar 2022 – YT//EYT (fig.) mit Akronymen zu befassen und sich zu ihrer Bedeutung im Markenrecht zu äussern. Das Urteil enthält weiter Anhaltspunkte, welche die bisherige Praxis, wonach die integrale Übernahme eines älteren Zeichens in die neuere Marke markenrechtlich grundsätzlich unzulässig ist, in Frage stellen. Das Urteil verdient zwar im Ergebnis Zustimmung, vermag aber in den zugrunde liegenden rechtlichen Ausführungen nicht durchgehend zu überzeugen.
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A l'occasion de l'arrêt B-1306/2021 du 1er février 2022 - YT//EYT (fig.), le Tribunal administratif fédéral a dû se pencher sur les acronymes et se prononcer sur leur signification dans le droit des marques. L'arrêt contient en outre des éléments qui remettent en question la pratique actuelle selon laquelle la reprise intégrale d'un sigle antérieur dans la marque plus récente est en principe inadmissible du point de vue du droit des marques. Bien que le résultat de l'arrêt mérite d'être salué, les explications juridiques qui le sous-tendent ne sont pas entièrement convaincantes.
Kanto’s Guest House Business Competitive Strategic Analysis for Sustainable Income
Authors: Rosita Ameliya 
Published: June 2022

This research aims to formulate and select Kantos House (KH) - Guest House strategy to face the competitive market in hotel accommodation industry for optimizing sustainable income through (1) evaluated brand awareness of KH; (2) identified external and internal factors that significant related to KH business, (3) analyzed brand effectiveness and competitive advantages of KH for optimizing sustainable income. This research method used Kapferer’s Prism for analyzing KH brand identity, multichannel online review for analyzing consumer feedback of output average score of company’s hotel score review, room occupancy company report for analyzing average rate of KH’s occupancy, and SWOT diagram analysis. The result of this research shows currently the design of company brand has accomplished all the six criteria based on Brand Identity Prism, unfortunately the brand awareness still on low level. This resulted related due to the absence of brand marketing communication company’s budget. Customer Review currently is very important for company, which proof by the management’s commitment to maintain the average rate of KH online review at least or more than 4,4 of 5 star “very good” (Google rating version), also by opening review channels for customer feedback by putting the sticker for TripAdvisor review on the wall near the lobby hotel also via online by adding sub- menu for the review purposed. The average level of KH’s room occupancy from 2017 until November 2018 was 82% and on 2017 was 87%. This result is favorable which the company’s position highly above of the Indonesian hotel’s average room occupancy in 2017 was on 65% (BPS 2017). The SWOT analysis result showed the position of KH was in the 1st quadrant means company on healthy condition which the suitable competitive strategy is growth or aggressive strategy.
Analysis Influence of NPL, Good Corporate Governance, and BOPO to Stock Prices on National Private Bank Period 2012 - 2018
Authors: Winoto Agustinus , Purba Hendryan Tua Marudut 
Published: June 2022

The level of performance of a bank has many factors that affect that stock prices, including internal factor from the bank itself. The purpose of this research is to analyse the Non-performing Loan, Good Corporate Governance, and Beban Operasional Pendapatan Operasional (BOPO) affect to stock prices simultaneously or partially on the national private private banks listed on the Indonesia Stock Exchange period 2012-2018. The sample in this study was 21 national private banks listed on the Indonesia Stock Exchange period 2012-2018. Data analysis model used is panel data regression using the software E-views 10. The results of this study indicate simultaneously the independent variables namely NPL, GCG and BOPO have a significant effect on stock prices in national private banks period 2012-2018, NPL have a significant effect on stock prices at national private private banks period 2012-2018, whereas GCG and BOPO do not significant effect on stock prices on the national private private bank period 2012-2018.
How to Develop Learning Styles to Encourage Gen Zers in Their Academic Performance and Workforce
Authors: Paulina Christine , Ernawati Endang 
Published: June 2022

The research aimed to find out the support of information communication and technology (ICT) to encourage generation Z (Gen Zers) in their learning style in academic environment as well as a preparation for their competences to enter the workforce. The research applied a qualitative method with literature study style. The studied literature consisted of primary sources such as articles, scientific papers, and the secondary sources, such as books, and some other internet sources. The literatures were comprehended by reading, understanding, analyzing, and synthesizing them to produce new findings in the form of information from various studied sources. Data analysis was done by using content analysis method by selecting, comparing, and combining various information so that the relevant knowledge was found to clarify the learning style needed by generation Z. The results indicate that generation Z learners like to use social media in the learning process and to interact with friends and teachers. In a higher education context, technological tools are utilised for online learning. The combination of digital tools in teaching-learning process and a suitable materials for generation Z learners is also important as it will engage students in the learning process. In entering the future workforce, generation Z learners are equipped with knowledge, skills, and competencies in English to support them in finding jobs locally and regionally.