bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostat Kanseri Kemik Metastazına Radyoterapi Uygulanan Hastalarda Sağ Kalımı Etkileyen Faktörler
Authors: MENTEŞ Selahattin , KARACA Feryal , KESKİN Sıddık 
Published: April 2022

Amaç: Bu çalışmada, prostat kanserlerinde metastatik kemiğe radyoterapi uygulanan hastalarda sağ kalım üzerine etkili olabileceği düşünülen faktörlerin karşılaştırılması amaçlanmıştır.
Gereç ve Yöntemler: Prostat kanserinin kemik metastazı nedeniyle radyoterapi almış olan 92 hasta çalışmaya dahil edilmiştir.
Bulgular: Yetmiş yaşından küçük hastalarda %57.1 oranında ölüm gözlenirken, >70 yaş hastalarda bu oran %74 olarak belirlenmiştir. Bu değerlerin karşılaştırılmasında her ne kadar istatistiksel olarak anlamlı fark görülmese de >70 olan hastaların ≤70 hastalara göre ölüm riskinin 2.135 kat daha yüksek olma
eğiliminde olduğu gözlenmiştir (p>0.05). Visseral organ metastazı ile birlikte kemik metastazı olan hastalarla, yalnız kemik metastazı olan hastaların sağ kalımı karşılaştırıldığında istatistiksel olarak anlamlı sonuç bulunmuştur (p
A Case of Non-Progressive Congenital Myopathy: Efficacy and Clinical Outcomes of The Wharton's Jelly Derived Mesenchymal Stem Cell Transplantation
Authors: Azeri Riza , Sun Eda , Karaoz Erdal 
Published: April 2022

Non-Progressive Congenital Myopathy is a disease characterized by muscle weakness, and unfortunately, there is no conventional treatment. In the last decade, regenerative medicine practices have become a rising value, and Mesenchymal Stem Cells (MSCs) have fascinating outcomes in regenerative medicine with their high regenerative capacities, their ability to regulate with paracrine secretions, and their immunological properties. Based on our experience in our previous clinical studies, Wharton's-Jelly-derived (WJ-)MSCs are the most suitable source for muscle diseases among all MSC sources. In this study, we evaluated the outcomes of 10 doses of WJ-MSC transplantation to the patient diagnosed with Non-Progressive Congenital Myopathy. A 17-year-old female with a SPEN-1 mutation, Non-Progressive Congenital Myopathy patient received 10 times as 1×10⁶/kg in the intra-arterial, intramuscular and intravenous administration of allogenic WJ-MSC. Before and after the treatment, the patient was followed-up with the upper extremity scale, Vignos lower extremity scale, muscle strength scale, functional independence measure, and evaluation of Serum creatine kinase (CK) levels. Improvement in both upper extremity scale and Vignos lower extremity scales, increasing in muscle strength, and decreasing in CK-level were detected. Although transplantation of WJ-MSC cannot treat any genetic-based diseases, they may benefit in alleviating clinical outcomes of disease. More importantly, WJ-MSC transplantation may offer a better quality of life by alleviating the symptoms of this rare disease with no treatment option that can be provided in conventional methods.
Acil Servise Başvuran Kronik ve Akut Hastalığı Olan Çocukların Annelerinde Depresyon ve Anksiyete Düzeylerinin Karşılaştırılması
Authors: TEKELİ Aysun , BODUR İlknur , ÖZTÜRK Betül , AKCA ÇAĞLAR Ayla , AÇIKEL Sadettin Burak , ÇOLAK Burçin , KARACAN Can Demir , TUYGUN Nilden 
Published: April 2022

Amaç: Ebeveynlerin kronik hastalığı olan çocuğa sahip olması yaşam kalitelerini ve ruhsal durumlarını olumsuz etkilemektedir. Çalışmamızda, kronik hastalığı olan ve önceden sağlıklı akut hastalık ile acil servise başvuran çocukların annelerinde sürekli ve durumluk kaygı düzeyleri ile depresyon düzeylerinin belirlenmesi ve bunu etkileyen faktörlerin değerlendirmesi amaçlanmıştır.
Gereç-Yöntem: Çalışmamız prospektif kesitsel bir çalışmadır. Çocuk Acil Kliniğine önceden sağlıklı ve akut hastalık ile başvuran çocukların anneleri ile kronik hastalığı olan çocukların anneleri çalışmaya dahil edildi. Beck Depresyon Ölçeği (BDÖ) ve Durumluk-Sürekli Kaygı Envanteri (State Trait Anxiety Inventory-STAI) çalışmaya katılan tüm annelere uygulandı. Olguların sosyodemografik verileri sosyodemografik veri toplama formu ile elde edildi. Mann-Whitney-U, Ki-kare ve tek yönlü Anova testleri ile post-hoc analizlerde Tukey HSD istatiksel analizler için kullanıldı.
Bulgular: Çalışmaya 101 (%49) kronik ve 105 (%51) akut hastalığı olan çocukların anneleri dahil edildi. Akut ve kronik hasta grupları arasında sürekli kaygı düzeyi ve BDÖ puanları arasında ise anlamlı farklılık saptanmıştır (sırasıyla p=0,004 ve p=0,001). Durumluk kaygı düzeyi puanlarında anlamlı farklılık saptanmamıştır (p=0,778). Hastalar BDÖ’nin kesme puanı (17 puan) dikkate alınarak muhtemel depresyon açısından ikiye ayrıldığında kronik hastalığı olan çocukların annelerinde akut hastalığı olan çocukların annelerine göre yüksek risk altında oldukları saptanmıştır (χ 2=8,641; p=0,004).
Sonuç: Çalışmamızın sonuçlarında kronik hastalığı olan çocukların annelerinde sürekli kaygı düzeyleri ve depresif belirti oranları önceden sağlıklı ve akut nedenle acil servise başvuran çocuk annelerine göre anlamlı yüksek tespit edilmiştir. Kronik grup ebeveynlerin eğitim ve sosyoekonomik düzeylerinin daha düşük olduğu saptanmıştır. Kronik hastalığı olan çocukların ebeveynleri ruhsal etkilenim açısından değerlendirilmeli, depresyon ve anksiyete gibi bozukluklar tespit edildiğinde psikolojik yardım almaları sağlanmalıdır.
ULTRASOUND ELASTOGRAPHY FINDINGS IN SJÖGREN’S SYNDROME
Authors: GÜNGÖR Özlem , ŞAHİN Kubilay , ÖZTÜRK Cansu , UYSAL RAMADAN Selma , CAN Sevinc , KAŞIKCI Merve 
Published: April 2022

Background/Aims: In Sjögren’s syndrome the basic histopathology in all affected organs is progressive lymphocyte infiltration This causes a change in tissue elasticity in the major salivary glands. The purpose of this study is to investigate salivary gland stiffness in primary Sjögren’s syndrome via shear wave elastography.
Material and Methods: According to the 2016 American European Consensus Group criteria, 47 female cases were included in the study as the "patient group" by two rheumatologists. A total of 41 healthy female volunteers, who were in a similar age group and had no symptoms of dry mouth or sicca, and no diagnosis of salivary gland disease, constituted the "control group" of the study .The paired parotid and submandibular glands of all subjects were examined with shear wave elastography. The study was conducted between October 2018-October 2019
Results: In our study, there was a significant difference in both parotid glands' tissue elasticity values in both speed and kPA values in cases with pSS compared to the control group. However, when the submandibular glands were evaluated, no significant difference was found between the two groups. In our study, no relationship was found between the duration of symptoms and elasticity values.
Conclusions :The fact that shear wave velocity (m / sec) and elasticity value (kPA) values are higher in the evaluation of the parotid gland by SWE technique in patients with pSS than the control group makes SWE an easy, non-invasive, and effective imaging method in Sjögren's Syndrome.
Climate-driven shifts in kelp forest composition reduce carbon sequestration potential
Authors: Wright Luka , Pessarrodona Albert , Foggo Andy 
Published: April 2022

Abstract
The potential contribution of kelp forests to blue carbon sinks is currently of great interest but interspecific variance has received no attention. In the Northeast Atlantic, kelp forest composition is changing due to climate-driven poleward range shifts of cold temperate Laminaria digitata and L. hyperborea and warm temperate L. ochroleuca. To understand how this might affect the carbon sequestration potential of these ecosystems, we quantified interspecific differences in carbon export and decomposition alongside changes in detrital photophysiology and biochemistry. We found that while warm temperate kelp exports up to 71% more carbon per plant, it decomposes up to 155% faster than its boreal congeners. Elemental stoichiometry and polyphenolic content cannot fully explain faster carbon turnover, which may be attributable to contrasting tissue toughness or unknown biochemical and structural defences. Faster decomposition causes the detrital photosynthetic apparatus of L. ochroleuca to be overwhelmed after 20 d and lose integrity after 36 d, while detritus of cold temperate species maintains carbon assimilation. Depending on the photoenvironment, detrital photosynthesis could further exacerbate interspecific differences in decomposition via a potential positive feedback loop. Via compositional change such as the predicted prevalence of L. ochroleuca, ocean warming will therefore likely reduce the carbon sequestration potential of these temperate marine forests.
Energy Efficient Dim and Dark Cache for Temperature Reduction of Chip
Multiprocessors
Authors: Kulkarni Ashwini , Mahajan Shrinivas P. 
Published: April 2022

Background:
For high computation, parallel and distributed processing chip multiprocessors
are widely used. In chip multiprocessors, large on chip cache memories are used for performance
improvement and speedy execution of the task. These cache memories consume 13% to 45%
of the overall power consumed by the entire chip. As chip size shrinks with technology scaling, static
energy consumed by the chip increases. This results in heating and chip malfunctioning. To solve
this problem we apply static energy reduction techniques to Last Level Cache (LLC) to reduce static
energy consumption and thereby chip temperature rise.

Methods:
Static energy reduction is achieved with two methods.
DIM_OLY_SEL Policy:- In this policy, static Energy Reduction is achieved by dimming cache
banks.
DIM_DARK_PAT Policy:- In this method, dimming as well as darkening techniques are used to
save static energy and thereby, temperature reduction.

Results:
With the implementation of DIM_OLY_SEL policy LLC, Temperature Reduction up to
1.4 Kelvin, improvements in EDP (Energy Delay Product) gains up to 28% and leakage energy Saving
up to 23% is observed.
With the implementation of DIM_DARK_PAT, we observed LLC temperature reduction up to 4.7
Kelvin, EDP gain improvement of 33 % and leakage energy saving 23%.

Conclusion:
DIM_OLY_SEL and DIM_DARK_PAT Policies are observed to be very effective
policies for energy saving and chip temperature reduction. Hence, they can be used effectively for
safe chip multiprocessor functioning.
Therapeutic Alliance in Web-Based Treatment for Eating Disorders: Secondary Analysis of a Randomized Controlled Trial
Authors: Stoeten Claudia , de Haan Hein Arnoud , Postel Marloes Gerda , Brusse-Keizer Marjolein , ter Huurne Elke Daniëlle 
Published: April 2022

Background
In face-to-face therapy for eating disorders, therapeutic alliance (TA) is an important predictor of symptom reduction and treatment completion. To date, however, little is known about TA during web-based cognitive behavioral therapy (web-CBT) and its association with symptom reduction, treatment completion, and the perspectives of patients versus therapists.

Objective
This study aimed to investigate TA ratings measured at interim and after treatment, separately for patients and therapists; the degree of agreement between therapists and patients (treatment completers and noncompleters) for TA ratings; and associations between patient and therapist TA ratings and both eating disorder pathology and treatment completion.

Methods
A secondary analysis was performed on randomized controlled trial data of a web-CBT intervention for eating disorders. Participants were 170 females with bulimia nervosa (n=33), binge eating disorder (n=68), or eating disorder not otherwise specified (n=69); the mean age was 39.6 (SD 11.5) years. TA was operationalized using the Helping Alliance Questionnaire (HAQ). Paired t tests were conducted to assess the change in TA from interim to after treatment. Intraclass correlations were calculated to determine cross-informant agreement with regard to HAQ scores between patients and therapists. A total of 2 stepwise regressive procedures (at interim and after treatment) were used to examine which HAQ scores predicted eating disorder pathology and therapy completion.

Results
For treatment completers (128/170, 75.3%), the HAQ-total scores and HAQ-Helpfulness scores for both patients and therapists improved significantly from interim to post treatment. For noncompleters (42/170, 24.7%), all HAQ scores decreased significantly. For all HAQ scales, the agreement between patients and therapists was poor. However, the agreement was slightly better after treatment than at interim. Higher patient scores on the helpfulness subscale of the HAQ at interim and after treatment were associated with less eating disorder psychopathology. A positive association was found between the HAQ-total patient scores at interim and treatment completion. Finally, posttreatment HAQ-total patient scores and posttreatment HAQ-Helpfulness scores of therapists were positively associated with treatment completion.

Conclusions
Our study showed that TA in web-CBT is predictive of eating disorder pathology and treatment completion. Of particular importance is patients’ confidence in their abilities as measured with the HAQ-Helpfulness subscale when predicting posttreatment eating disorder pathology and treatment completion.
A Nurse-Led Multimedia Intervention to Increase Patient Participation in Recovery After Knee Arthroplasty: Hybrid Type II Implementation Study
Authors: McDonall Jo , Redley Bernice , Livingston Patricia , Hutchinson Ana , de Steiger Richard , Botti Mari 
Published: April 2022

Background
Advances in digital technology and the use of multimedia platforms to deliver information provide clinicians with a unique opportunity to develop innovative ways to consistently provide high-quality, accessible, and evidence-based information to support patient participation. Introducing new technologies into everyday acute care clinical practice can be difficult.

Objective
The aim of this paper was to provide a description of an implementation strategy and the subsequent evaluation undertaken to examine the contextual factors important to the successful adoption of new technology by nurses in the context of acute postoperative care.

Methods
Implementation of the intervention and process evaluation was undertaken in 3 phases: phase 1, preimplementation stakeholder engagement and identification of barriers and enablers to implementation; phase 2, supported implementation of the intervention; and phase 3, evaluation of uptake, usability, and acceptability of the intervention in clinical practice.

Results
The outcomes of the implementation of the multimedia intervention in the context of acute postoperative care were positive. Of the 104 patients in the intervention group, 103 (99%) received the intervention. All 103 patients completed the 8-item intervention questionnaire and 93.3% (97/103) were interviewed on day 3 to evaluate usability, uptake, and acceptability. Of these 97 patients, almost all (n=94, 91%) found the program easy to use and most (n=64, 62%) could view the MyStay Total Knee Replacement program as often as they wanted. The findings also suggest that the time to implement the program was minimal (5-10 minutes). Collaboration with nurses and patients before and during implementation to identify potential barriers to successful implementation of the intervention was essential to develop timely strategies to overcome these barriers. To ensure end-user engagement, careful consideration was given to nurses’ views on who was responsible for facilitating this intervention.

Conclusions
The findings provide evidence that the structured implementation of the multimedia intervention was robust and successful in terms of patient participant recruitment and application; however, it was difficult to assess the level of engagement by nurse clinicians with the program.

Trial Registration
Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12614000340639; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12614000340639
PERANCANGAN ARSITEKTUR ENTERPRISE SISTEM INFORMASI MENGGUNAKAN TOGAF ADM DI SMA NEGERI 1 SINGARAJA
Authors: Adi Sista Dewa Nyoman , Candiasa I Made , Aris Gunadi I Gede 
Published: April 2022

Penelitian ini bertujuan untuk mendefinisikan serta menguji efektivitas TOGAF ADM sebagai model arsitektur enterprise sistem informasi guna mendukung aktivitas bisnis di SMA Negeri 1 Singaraja.Â Secara garis besar data pada penelitian ini diambil dengan teknik wawancara dan observasi kemudian dianalisis menggunakan pemodelan TOGAF ADM. Adapun perangkat yang digunakan untuk memodelkan fase dalam TOGAF ADM adalah analisis SWOT, Value Chain, Bussiness Process Modeling and Notation, Unified Modelling Language, McFarland Strategic, dan Focus Group Discussion (FGD). Hasil penelitian ini berupa (1) rekomendasi pembuatan aplikasi, (2) rekomendasi topologi jaringan, (3) rekomendasi hardware dan software, (4) usulan urutan implementasi dan (5) roadmap implementasi dari rekomendasi-rekomendasi yang telah diberikan, serta (6) pengujian menggunakan teknik FGD. Dari hasil pengujian diperoleh hasil bahwa rekomendasi peneliti diterima dengan baik oleh peserta dan diharapkan dapat direalisasikan. Sedangkan hambatan yang akan ditemui ketika mengimplementasikan sistem informasi ini adalah pada proses mengubah kebiasaan para guru, pegawai dan siswa yang telah sekian lama mengandalkan pekerjaan secara manual. Serta faktor usia pada guru dan pegawai juga akan menjadi penghambat dalam proses penyesuaian tersebut.
KARAKTERISTIK RDF DARI SAMPAH KOTA TERSELEKSI YANG DIHASILKAN OLEH PYROLYSER ULIR
Authors: Himawanto Dwi Aries 
Published: April 2022

Penelitian ini bertujuan untuk menemukan kondisi temperatur slow pyrolysis yang sesuai dari sampah kota terseleksi (segregated municipal solid wastes) guna menghasilkan bahan bakar padat alternatif (Refused Derived Fuel) secara berkesinambungan dengan menggunakan screw pyrolyser.Untuk mencapai tujuan tersebut, maka dilakukan rekaya peralatan proses slow pyrolisis secara berkesinambungan dalam skala laboratorium dengan menggunakan Â screw pyrolyser yang tepat agar menghasilkan Refused Derived Fuel yang memiliki karakteristik produk minimal sama dengan hasil studi sebelumnya. Penelitian dilakukan dengan 5 variasi temperatur reaktor yaitu 3000C, 3500C, 4000C , Â 4500CÂ dan 5000C ..Dengan menggunakan prototipe pyrolyser ulir dengan kemampuan proses 6 kg/jam, dengan produk char yang dihasilkan terbaik didapatkan pada komposisi 70 % sampah organik yang dipirolisa pada temperatur pyrolyser 450Â°C. Char yang dihasilkan mengandung kadar air 1,77 %, kadar abu 9,66 %, volatile matter 66,387 % dan karbon tetap 22,17% serta memiliki nilai kalor 6,86 kkal/gram. Efisiensi proses yang didapatkan berkisar 95,3%.
UNDIKSHA VIRTUAL ASSISTANT (SHAVIRA): INTEGRATION FREQUENCY ASKED QUESTION WITH RASA FRAMEWORK
Authors: Resika Arthana I Ketut , Dewi Luh Joni Erawati , Seputra Ketut Agus , Marti Ni Wayan 
Published: April 2022

Nowadays, the implementation of chatbots in information systems is getting popular to increase user experience. In our previous research, we developed Undiksha Virtual Assistant (Shavira). Shavira is a knowledge management system (KMS) as Frequency Asked Question (FAQ) system to facilitate users to get an answer about their questions. The challenge on the existing Shavira system is that the users must open a website and type queries to get a list of answers. The text query must match with the keyword in systems. To address this problem and to avoid cognitive load, in this research we implemented a chatbot in Shavira. The purpose of the chatbot implementation in Shavira is to make information easier to be accessed and to increase user experience. The users can ask a question in natural language and get an answer immediately on their chat application such as: Telegram, Facebook, or Messenger. We used Rasa Framework as a chatbot engine in Shavira. Rasa Framework is an open-source virtual assistant engine based on artificial intelligence. The challenge in conducting this research is in integrating the existing FAQ system with Rasa Framework. This research consists of four phases, they are: adaptation data structure in the existing FAQ with data structure requested by Rasa framework, data integration and mapper, and evaluation. The result of this research is a new Shavira that is integrated with a chatbot and can be accessed from chat applications such as Telegram.Â We evaluated the accuracy of Shavira powered by Rasa Framework with ten topics about academic information. The results showed that the accuracy of Shavira is 90%. We also evaluated the usability of Shavira with Software Usability Scale (SUS) Questionnaire. The usability evaluation showed that Shavira satisfied users with valueÂ 81 (threshold 68) and categorized Excellent, Acceptable and Prometer.
METODA FAST FORWARD UNTUK MEMPERCEPAT DINAMIKA KUANTUM ADIABATIK PADA SPIN TUNGGAL
Authors: Benggadinda Annisa , Setiawan Iwan 
Published: April 2022

AbstrakPenelitian ini membahas metode percepatan dinamika kuantum adiabatikÂ pada sistem spin tunggal yaitu dinamika spin yang bergerak pada keadaan awal up (atas) akan bergerak ke down (bawah) pada keadaan akhir. Metode ini disebut skema fast forward. Metode ini pertama kali di usulkan oleh Masuda dan Nakamura. Dalam metode ini, skema percepatan dibangun dengan menambahkan suku interaksi penggerak ke Hamiltonian awal dan mempercepatnya dengan menggunakan faktor penskalaan waktu yang bernilai besar dan parameter adiabatik yang menuju nol (0) dan bertujuan mewujudkan dinamika kuantum adiabatik pada waktu yang singkat dan dengan penambahan medan magnet penggerak. Hamiltonian penggerak dan medan magnet penggerak ini menjamin spin tunggal dapat bergerak dari keadaan awal ke keadaan akhirÂ dalam waktu yang singkat tanpa mengubah karakteristik awalnya.Â Kata kunci: Adiabatik, Dinamika Kuantum, Spin tunggalÂ AbstractThis study discusses the method of accelerating adiabatic quantum dynamics in a single spin system, namely the dynamics of a spin that moves in the up initial state will move down in the final state. This method is called a fast forward scheme. This method was first proposed by Masuda and Nakamura. In this method, the acceleration scheme is constructed by adding the driving interaction term to the initial Hamiltonian and accelerating it by using a large time scaling factor and adiabatic parameter towards zero (0) and aims to realize adiabatic quantum dynamics in a short time andÂ by adding a driving magnetic field. The driving Hamiltonian and the driving magnetic field ensure that a single spin can move from its initial state to its final state in a short time without changing its initial characteristics.Â Keywords : Adiabatic, Quantum Dynamics, Single Spin