bluuebunny/crossref_metadata_2025_split huggingface dataset:
Editorial: A case for diversity in educational research and educational practice
Authors: Biesta Gert , Wainwright Emma , Aldridge David 
Published: February 2022

AbstractIn this editorial we explore how diversity might matter for educational research and educational practice. We highlight that diversity constitutes a value in itself and can be valued for its consequences. We suggest that valuing diversity doesn't mean that any diversity is simply acceptable. Diversity, so we argue, requires a criterion, and we suggest that democracy may be a relevant criterion for diversity. We also argue that diversity needs a reference point so that rather than talking about diversity in the abstract, it is important to explore in what particular contexts and settings diversity may matter. Against this background we highlight the importance of methodological, conceptual and theoretical diversity in educational research, also for the sake of the diversity of educational practice.
Simulating denial increases false memory rates for abuse unrelated information
Authors: Bücken Charlotte A. , Mangiulli Ivan , Otgaar Henry 
Published: February 2022

AbstractVictims of abuse might deny their traumatic experiences. We studied mnemonic effects of simulating false denial of a child sexual abuse narrative. Participants (N = 127) read and empathized with the main character of this narrative. Next, half were instructed to falsely deny abuse‐related information while others responded honestly in an interview. One week later, participants received misinformation for the narrative and interview. In a final source memory task, participants' memory for the narrative and interview was tested. Participants who falsely denied abuse‐related information endorsed more abuse‐unrelated misinformation about the event than honest participants. Abuse‐related false memory rates did not statistically differ between the groups, and false denials were not related to omission errors about (1) the interview and (2) narrative. Hence, victim's memory for abuse‐related information related to their experience might not be affected by a false denial, and inconsistencies surrounding the abuse‐unrelated information are more likely to take place.
Autologous blood injection intracoronary artery for treating slow‐flow and no‐reflow in acute coronary syndrome related to primary pci
Authors: Truong Hoai Lam , Nguyen Xuan Duy , Nguyen Duc Hung , Nguyen Tuan Long 
Published: February 2022

AbstractSlow‐flow and no‐reflow phenomenon are taken to sudden loss of coronary artery flow, typically after stenting or angioplasty in primary PCI. Otherwise conventional therapy, we report a technique, which autologous blood into intracoronary to supply oxygen and break process thrombosis results in successfully management no‐reflow in primary PCI in ACS.
Coexistence of thrombotic thrombocytopenic purpura and adult‐onset Still's disease
Authors: Ben Salah Raida , Bouattour Yosra , Turki Chourouk , Frikha Faten , Bahloul Zouhir 
Published: February 2022

AbstractThe association of Thrombotic thrombocytopenic purpura (TTP) and adult‐onset Still's disease (AOSD) is very uncommon. Hereby, we present a case of TTP occurring in patient with a known AOSD and the successful outcome after plasma exchanges.
“Burgundy wine” pleural effusion: An unusual manifestation of acute bacterial empyema
Authors: Kuwahara Daichi , Okazaki Akihito 
Published: February 2022

AbstractAlthough empyema diagnosis by thoracentesis is relatively straightforward, the pleural effusion can sometimes be bloody rather than purulent. We report a case of acute empyema with a dark‐red bloody effusion, wherein multiple anaerobic bacteria were detected. Chest imaging findings improved with pleural drainage, intrapleural fibrinolytic therapy, and intravenous antibiotic treatment.
Preoperative diagnosis of gallbladder torsion by magnetic resonance cholangiopancreatography: A case report
Authors: Miyata Takashi , San‐nomiya Yuta , Nagayama Taigo , Kin Ryosuke , Nishiki Hisashi , Hashimoto Akifumi , Fujii Yoritaka , Miura Seiko , Kaida Daisuke , Tomita Yasuto , Nakamura Naohiko , Miyashita Tomoharu , Fujita Hideto , Ueda Nobuhiko , Takamura Hiroyuki 
Published: February 2022

AbstractGallbladder torsion is a rare and potentially fatal condition presenting with acute abdominal pain. Gallbladder torsion requires early diagnosis and treatment; however, preoperative diagnosis is difficult. In the present case, magnetic resonance cholangiopancreatography provided definitive imaging findings and was very useful in making the preoperative diagnosis.
Carbohydrate‐Functionalized Triazolylidene Iridium Complexes: Hydrogenation Catalysis in Water with Asymmetric Induction
Authors: Byrne Joseph P. , Delgado Lidia , Paradisi Francesca , Albrecht Martin 
Published: February 2022

AbstractTwo sets of carbohydrate‐NHC hybrid iridium complexes were synthesised in order to combine properties of carbohydrates and triazolylidene (trz) ligands in organometallic catalysis. One set features a direct trz linkage to the anomeric carbohydrate carbon, while the second set is comprised of an ethyl linker between the two functional units. Deprotection of the carbohydrate afforded hybrid complexes that efficiently catalyse the direct hydrogenation of ketones in water. The catalytic activity of the hybrid complexes was influenced by the pH of the aqueous medium and surpassed the activity of carbohydrate‐free or acetyl‐protected analogues (>90 % vs 13 % yield). While no enantiomeric induction was observed for the ethyl‐linked hybrids, a moderate enantiomeric excess (ee) was induced by the directly linked systems. Moreover, these carbohydrate‐trz hybrid complexes displayed mixed inhibitory activity towards a glycosidase from H. orenii that contain a glucose binding site.
Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A
Authors: Bando Yuko , Hou Yu , Seyfarth Lydia , Probst Jannik , Götze Sebastian , Bogacz Marta , Hellmich Ute A. , Stallforth Pierre , Mittag Maria , Arndt Hans‐Dieter 
Published: February 2022

AbstractA total synthesis of the cyclic lipodepsipeptide natural product orfamide A was achieved. By developing a synthesis format using an aminoacid ester building block and SPPS protocol adaptation, a focused library of target compounds was obtained, in high yield and purity. Spectral and LC‐HRMS data of all library members with the isolated natural product identified the 5Leu residue to be d‐ and the 3’‐OH group to be R‐configured. The structural correction of orfamide A by chemical synthesis and analysis was confirmed by biological activity comparison in Chlamydomonas reinhardtii, which indicated compound configuration to be important for bioactivity. Acute toxicity was also found against Trypanosoma brucei, the parasite causing African sleeping sickness.
Behavioral Testing Design for Evaluation of Cognitive Disabilities
Authors: Riet Fabrice , Mittelhaeuser Christophe , Lux Aline , Bour Raphael , Selloum Mohammed , Sorg Tania , Herault Yann , Meziane Hamid 
Published: February 2022

AbstractIntellectual disabilities (ID) constitute a class of human neurodevelopmental diseases and are a major medical and socioeconomic problem owing to their high incidence and enormous burden to the families of those affected. In the past three decades, mutant mouse technologies have provided powerful tools for elucidating the pathophysiological mechanisms underlying behavioral and developmental alterations related to IDs and for addressing new therapeutic strategies, and major progress has been made revealing previously unidentified genes involved in ID. However, the pathological hallmarks of IDs are very heterogeneous in regard to both the functional deficits observed and the severity of the phenotype, even within the same mutation types. For this reason, an appropriate experimental design is required to reduce the risk of false negatives and positives in animal functional genomic studies. This experimental design should address functions important to evaluate, tests, and the appropriate workflow. Here, we propose an extensive behavioral screen with detailed protocols, which was successfully used in a systematic mouse functional genomic approach to gain pathway‐based insights into mechanisms leading to cognitive dysfunction in humans. © 2022 Wiley Periodicals LLC.Basic Protocol 1: Assessment of circadian activity and ingestive behaviorBasic Protocol 2: Assessment of neurological reflexes and motor abilities using the grip and rotarod testsBasic Protocol 3: Evaluation of anxiety‐related behavior using the elevated plus mazeBasic Protocol 4: Evaluation of recognition memory using the object recognition taskBasic Protocol 5: Evaluation of social behavior using the social recognition testBasic Protocol 6: Evaluation of working memory using the Y‐maze spontaneous alternation testBasic Protocol 7: Evaluation of emotional learning and memory using the fear conditioning test
Visualizing Endogenous Necrosomes in Necrosomes by In Situ Proximity Ligation Assay
Authors: Liang Wei , Yuan Junying 
Published: February 2022

AbstractNecroptosis is a regulated form of necrosis that has been shown to participate in the pathogenesis of major human inflammatory and neurodegenerative diseases. Formation of a necrosome, composed of the RIPK1/RIPK3 complex, drives the execution of necroptosis. Although the co‐immunoprecipitation (co‐IP) assay has been widely used as a biochemical protocol for studying necrosomes, the technical limitations of co‐IP prevent its use for identifying necrosomes in complex tissues and for investigating the subcellular localization of necrosomes. The development of a specific assay for visualizing necrosomes in situ is needed. Here, we developed an in situ proximity ligation assay (PLA), which converts the detection of protein‐protein interaction to detection of DNA product by rolling‐circle amplification for investigating the endogenous necrosome in situ and in tissues. This protocol describes an in situ PLA that we have developed for visualizing endogenous necrosomes in necroptosis in both human and mouse cells and in mouse embryos with sensitivity and specificity. © 2022 Wiley Periodicals LLC.Basic Protocol 1: Detection of RIPK1/RIPK3 interaction by in situ proximity ligation assay in human and mouse cells
Measurements of hydrocortisone and cortisone for longitudinal profiling of equine plasma by liquid chromatography–tandem mass spectrometry
Authors: Tou Kathy , Cawley Adam , Bowen Christopher , Sornalingam Kireesan , Fu Shanlin 
Published: February 2022

AbstractThe conventional detection of exogenous drugs in equine doping samples has been used for confirmation and subsequent prosecution of participants responsible. In recent years, alternative methods using indirect detection have been investigated due to the expanding number of pharmaceutical agents available with the potential of misuse. The monitoring of endogenous biomarkers such as hydrocortisone (HC) has been studied in equine urine with an international threshold of 1 μg/ml established; however, there is no current threshold for equine plasma. The aim of this research was to investigate plasma concentrations of HC and cortisone (C) in race day samples compared to an administration of Triamcinolone Acetonide (TACA). The reference population (n = 1150) provided HC (6 to 145 ng/ml) and C (0.7 to 13 ng/ml) levels to derive the HC to C ratio (HC/C). Population reference limits (PRLs) were proposed for HC/C values at 0.2 (lower) and 61 (upper). Administration of TACA resulted in down‐regulation of HC/C values below the estimated PRLs for up to 96 h post‐administration. This indirect detection period was longer than the detection of TACA for 72 h. The use of individual reference limits (IRLs) for HC/C values was investigated to support the Equine Biological Passport (EBP), an intelligence model developed by Racing NSW for longitudinal monitoring of biomarkers.
Metabolomics in clinical and forensic toxicology, sports anti‐doping and veterinary residues
Authors: Keen Bethany , Cawley Adam , Reedy Brian , Fu Shanlin 
Published: February 2022

AbstractMetabolomics is a multidisciplinary field providing workflows for complementary approaches to conventional analytical determinations. It allows for the study of metabolically related groups of compounds or even the study of novel pathways within the biological system. The procedural stages of metabolomics; experimental design, sample preparation, analytical determinations, data processing and statistical analysis, compound identification and validation strategies are explored in this review. The selected approach will depend on the type of study being conducted. Experimental design influences the whole metabolomics workflow and thus needs to be properly assessed to ensure sufficient sample size, minimal introduced and biological variation and appropriate statistical power. Sample preparation needs to be simple, yet potentially global in order to detect as many compounds as possible. Analytical determinations need to be optimised either for the list of targeted compounds or a universal approach. Data processing and statistical analysis approaches vary widely and need to be better harmonised for review and interpretation. This includes validation strategies that are currently deficient in many presented workflows. Common compound identification approaches have been explored in this review. Metabolomics applications are discussed for clinical and forensic toxicology, human and equine sports anti‐doping and veterinary residues.
Validation of a single liquid chromatography‐tandem mass spectrometry approach for oxytetracycline determination in bull plasma, seminal plasma and urine
Authors: Bardhi Anisa , Gazzotti Teresa , Pagliuca Giampiero , Mari Gaetano , Barbarossa Andrea 
Published: February 2022

AbstractOxytetracycline is a broad‐spectrum antibiotic, which inhibits protein synthesis and is generally used for the treatment of pneumonia, shipping fever, leptospirosis and wound infections in cattle and swine. The present work proposes a novel liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for oxytetracycline quantification in bull plasma, seminal plasma and urine, requiring limited sample treatment before analysis. Extraction with trichloroacetic acid followed by dilution of the supernatant in mobile phase proved to be effective in all three matrices, allowing to rapidly process large batches of samples. Sharp and symmetrical peak shape was obtained using a BEH C18 reversed‐phase column in a chromatographic run of just 3.5 min. The mass spectrometer operated in positive electrospray ionization mode and monitored specific transitions for oxytetracycline (461.1 → 425.8) and the internal standard demeclocycline (465.0 → 447.6). The method was validated over concentration ranges suitable for field concentrations of oxytetracycline found in each matrix, showing good linearity during each day of testing (R2 always >0.99), as also confirmed by analysis of variance (ANOVA) and lack‐of‐fit tests. Excellent accuracy and precision were demonstrated by calculated bias always within ±15% and CV% below 10% at all quality control (QC) levels in the three matrices. Matrix effect and recovery were investigated for both analytes, which showed consistent and comparable behaviour in each matrix. To our knowledge, this is the first validated approach for mass spectrometric determination of oxytetracycline in seminal plasma and urine. The method was successfully applied to samples collected during a pharmacokinetic study in bulls, allowing to assess the oxytetracycline concentration–time profile in plasma, seminal plasma and urine.
Source of the aeolian sediments in the Yarlung Tsangpo valley and its potential dust contribution to adjacent oceans
Authors: Ling Zhiyong , Yang Shengli , Xia Dunsheng , Wang Xin , Chen Fahu 
Published: February 2022

AbstractSurface sediments such as aeolian sand, loess/sandy loess, and fluvial/alluvial clastics are widespread in the Yarlung Tsangpo (YT) catchment and across the Tibetan Plateau (TP). However, it is debated whether the source of the aeolian sediments is local or remote, involving transport across large regions, and whether the surface sediments, especially aeolian deposits, are a major source of global dust. Here, we use strontium‐neodymium (Sr‐Nd) isotopic analysis and modern observations of dust emissions to investigate the provenance of aeolian sediments from the YT catchment and adjacent areas during different periods (modern, Holocene, Late Pleistocene), and the relationship between surface sediments of the TP and the dust component of sediments in the Japan Sea and the North Pacific Ocean. Strontium‐87/strontium‐86 (87Sr/86Sr) and neodymium isotopic ratio (εNd) show a wide range of variation in different areas (87Sr/86Sr varies from 0.707996 to 0.731078, and εNd from −6.2 to −13.6), influenced by the composition of the clastic material derived from the local parent rock; additionally, there are no significant variations between size fractions. Due to local recycling the aeolian sedimentary systems in the southern TP are supplied with clastic material from proximal sources, and they are unlikely to receive large quantities of long‐range dust transported from regions such as the Taklimakan desert in Central Asia. Dust emission occurs mainly in the dry season (from March to May) and the dust is carried on the upper‐level westerly jet stream and then deposited downwind in the Japan Sea and the North Pacific Ocean, thus contributing to global dust.
Machine learning for power control in device‐to‐device communications with full‐duplex relays using ITLinQ spectrum sharing scheme
Authors: Taheri Hanjani Zahra , Mohammadi Abbas , Dosaranian‐Moghadam Mohamad , Kazemi Mohammad 
Published: February 2022

AbstractA proposed mechanism for interference management and scheduling links in device‐to‐device (D2D) networks with full‐duplex relays (FDRs) is FDR‐information theoretic links scheduling (FDR‐ITLinQ).This article employs a machine learning (ML) technique with the FDR ITLinQ spectrum sharing method in D2D communications. In this article, transmission powers of transmitters and corresponding relays are determined with a Full‐duplex relay (PC) mechanism employing genetic algorithm (GA). The objective function is maximizing two main criteria of evaluation of network performance. The first criterion is the average sum rate (ASR), and the second is energy efficiency (EE). In addition, addressing two objectives simultaneously leads to a trade‐off between ASR and EE. Therefore, employing the ML strategy, we determine the transmission powers of transmitters and their corresponding relay pairs. The ML strategy has more flexibility and lower computational complexity in comparison to the traditional optimization methods. The proposed neural network (NN) considers the channel coefficients as inputs and optimal power for transmitters and relays as outputs. The optimal allocated power for new situations and conditions are predicted via trained NN. The simulation results show that the PC mechanism that uses the ML approach has almost the same performance as GA. However, the superiority of ML approach over GA is that the calculation time and system complexity are reduced, which, in turn, makes the proposed scheme applicable to implement in practical networks.
Chemical constituents and bioactivities of hops (Humulus lupulus L.) and their effects on beer‐related microorganisms
Authors: Sun Shaokang , Wang Xiaochen , Yuan Ai , Liu Jianlin , Li Zebin , Xie Dongxiao , Zhang Huimin , Luo Wenqing , Xu Hengyuan , Liu Jinshang , Nie Cong , Zhang Haojun 
Published: February 2022

AbstractThe female inflorescence of hops is traditionally used in the brewing industry to impart bitterness, aroma, flavour and longer shelf life to beer, where the bittering acids are the main compounds that enhance the quality of the beer. In recent years, a wide variety of bioactive compounds have been reported to be present in female flowers. Due to the growing consumer interests in natural ingredients, a great deal of research has been carried out in the last few years to find new sources of functional biomolecules. This paper reviews the recent applications of hops in the food, pharmaceutical and cosmetic industries and provides an overview of the bioactive potential of hops. In addition, the analytical techniques of hops compound are reviewed. The biological activities of hops compound such as antibacterial, antifungal, cardioprotective, antioxidant, anti‐inflammatory and anticancer are reviewed and the recent effects of hop bittering derivatives on beer‐related microbial activity are also presented. It is thus clear that hops have a high potential as bioactive components for use as preservatives in fresh foods to extend shelf life and as cosmetic formulations for skin care products as well as nutraceutical and health implications.
Efficacy of programmed cell death 1 inhibitor maintenance therapy after combined treatment with programmed cell death 1 inhibitors and anti‐CD19‐chimeric antigen receptor T cells in patients with relapsed/refractory diffuse large B‐cell lymphoma and high tumor burden
Authors: Mu Juan , Deng Haobin , Lyu Cuicui , Yuan Jijun , Li Qing , Wang Jia , Jiang Yanyu , Deng Qi , Shen Jichun 
Published: February 2022

AbstractWe studied the efficacy and safety of the combined treatment with programmed cell death 1 (PD‐1) inhibitors and anti‐CD19 chimeric antigen receptor (CAR) T‐cell therapy and subsequent PD‐1 inhibitor maintenance treatment in patients with relapsed/refractory (R/R) diffuse large B‐cell lymphoma (DLBCL) and high tumor burden. Forty‐four R/R DLBCL patients with high tumor burden were enrolled in this study. The experimental group of 26 patients received combined therapy with PD‐1 inhibitors and anti‐CD19‐CAR T cells, while the control group of 18 patients received anti‐CD19‐CAR T‐cell therapy alone. The objective response rate (ORR) was 65.39% and 61.11% in the combination and control groups, respectively. The PD‐1 inhibitor maintenance therapy was selected for patients who achieved complete response or partial response in the combination therapy group. Progression‐free survival and overall survival rates in the combination group were higher than those in the control group 3 and 12 months after CAR T‐cell infusion. There was no significant difference in the grade of cytokine release syndrome or immune effector cell associated neurotoxic syndrome between the two groups. In the maintenance therapy group, only eight patients experienced grade 1 Common Terminology Criteria for Adverse Events (CTCAE) and three grade 2 CTCAE. Overall, we found that the ORR was not affected by the combination therapy with PD‐1 inhibitors and anti‐CD19‐CAR T cells. However, patients who had achieved the ORR might benefit from PD‐1 inhibitor maintenance therapy after combination therapy without increased side effects.