bluuebunny/crossref_metadata_2025_split huggingface dataset:
MODEL PENGEMBANGAN DAN PEMBERDAYAAN MASYARAKAT BERBASIS KEMANDIRIAN UNTUK MEWUJUDKAN KETAHANAN EKONOMI DAN KETAHANAN PANGAN (Strategi Pemberdayaan Ekonomi Pada Masyarakat Dieng Di Propinsi Jawa Tengah)
Authors: Prawoto Nano 
Published: June 2022

Research on the development and empowerment of community-based self-reliance to increase community food security Dieng in Central Java province is descriptive investigative research to gain an overview of the problems of economic development community, especially regarding food security. The output of this research program and the completion of strategic activities (strategic plan) an integral and comprehensive in order to improve food security and economic empowerment Dieng community. This research method to apply multiple methods of analysis (multi-methods analysis) is by applying several methods that Quotion Loqation method (LQ), SWOT analysis, trend analysis, and analysis of the Economic Empowerment of the agricultural sub-sector. This study has value and strategic objectives as well as provide important information to improve community food security in particular Dieng and underserved communities in Indonesia in general.
Penelitian mengenai pengembangan dan pemberdayaan masyarakat yang berbasis kemandirian untuk peningkatan ketahanan pangan masyarakat Dieng di provinsi Jawa Tengah merupakan penelitian deskriptif investigatif untuk memperoleh gambaran tentang permasalahan pembangunan ekonomi masyarakat khususnya menyangkut ketahanan pangan. Output dari kegiatan penelitian ini yaitu tersusunnya program dan kegiatan strategik (strategic plan) secara integral dan komprehensif dalam rangka meningkatkan pemberdayaan ekonomi dan ketahanan pangan masyarakat Dieng. Metode penelitian ini menerapkan beberapa metode analisis (multi-methods analysis) yaitu dengan mengaplikasikan beberapa metode yaitu metode Loqation Quotion (LQ), analisis SWOT, analisis Trend, dan analisis Pemberdayaan Ekonomi Masyarakat pada sub-sektor pertanian. Penelitian ini memiliki nilai dan tujuan strategis disamping memberikan informasi penting untuk meningkatkan ketahanan pangan masyarakat Dieng khususnya dan masyarakat tertinggal di Indonesia pada umumnya.
Characteristics of Strong Ground Motions in the 30 October 2020, MW6.9 Aegean Sea Earthquake
Authors: Malcioglu Fatma Sevil , O’Kane Aisling , Donmez Kokcan , Aktas Yasemin D. 
Published: June 2022

The eastern parts of the Aegean Sea were struck by a destructive MW 6.9 earthquake on 30 October 2020 at 11:51:27 UTC. The earthquake ruptured an East-West trending normal fault in the Aegean Sea between the northern coast of Samos Island and the southern coast of İzmir and also triggered a medium level tsunami and thousands of aftershocks across the region. 119 fatalities, 1,051 injuries, and many collapsed buildings were reported due to the earthquake in the affected region. The most catastrophic consequences of the earthquake were registered in the Bayraklı and Bornova districts, which are built on a deep alluvial Basin approximately 60–70 km away from the epicentre of the mainshock. This paper explains the damage with an extensive dataset of ground motion records of the mainshock and aftershocks, which are provided by both Greek and Turkish networks. A set of ground motion parameters such as peak ordinates, spectral quantities, intensity measures and duration parameters are calculated and analysed. The closest softer soil station in Samos Island produces the highest peak ground acceleration and velocity. The ground motion models employed commonly for the region overestimate the observed data beyond 60–70 km of Joyner-Boore distance except for the recently published local ground motion model, which utilises local earthquakes in the derivation of the model. Contrary to expectations, stiff soil recordings exhibit considerable spectral accelerations in the long period region, similar to those in soft soils. The calculated ground motion parameters are correlated with the results of the hybrid reconnaissance mission, organized by the Earthquake Engineering Field Investigation Team (EEFIT). Although the peak values and regarded intensity measures clearly highlight the variability in soil conditions in the most damaged area (Bayraklı and Bornova), velocity-based ground motion parameters seem to be the more responsive damage indicators. The spectral shapes of the normalised response spectra in the İzmir Basin are not compatible with the 2018 Turkish seismic code spectrum whereas their response spectra are below the 475-years return period design spectra provided in outdated and current Turkish seismic codes.
Developing an Immune-Related Signature for Predicting Survival Rate and the Response to Immune Checkpoint Inhibitors in Patients With Glioma
Authors: Zhang Sibin , Xiao Xu , Wang Yu , Song Tianjun , Li Chenlong , Bao Hongbo , Liu Qing , Sun Guiyin , Sun Xiaoyang , Su Tianqi , Fu Tianjiao , Wang Yujie , Liang Peng 
Published: June 2022

Background: Glioma is one of the most aggressive cancer types affecting the central nerve system, with poor overall survival (OS) rates. The present study aimed to construct a novel immune-related signature to predict prognosis and the efficiency of immunotherapy in patients with glioma.Methods: The mRNA expression data and other clinical information of patients with glioblastoma multiforme (GBM) and low grade glioma (LGG) were obtained from The Cancer Genome Atlas and Chinese Glioma Genome Atlas databases. The immune-related genes were obtained from the Immunology Database and Analysis Portal database. Subsequently, an immune-related signature was created following the results obtained from the Least Absolute Shrinkage and Selection Operator regression model. To validate the predictability of the signature, Kaplan-Meier survival curves and time-dependent receiver operating characteristic curves were created. Moreover, both univariate and multivariate analyses were carried out using the OS between this signature and other clinicopathologic factors, and a nomogram was constructed. In addition, the association between signature, immune cell infiltration, tumor mutation burden and immunophenoscore were determined.Results: Results of the present study using 118 GBM and LGG samples uncovered 15 immune-related genes that were also differently expressed in glioma samples. These were subsequently used to construct the immune-related signature. This signature exhibits the ability to predict prognosis, the infiltration of immune cells in the tumor microenvironment and the response of patients with glioma to immunotherapy.Conclusion: Results of the present study demonstrated that the aforementioned novel immune-related signature may accurately predict prognosis and the response of patients with glioma to immunotherapy.
Serum Immunoglobulins, Pneumonia Risk, and Lung Function in Middle-Aged and Older Individuals: A Population-Based Cohort Study
Authors: Khan Samer R. , Vanoverschelde Anna , Lahousse Lies , Peeters Robin P. , van Hagen P. Martin , Brusselle Guy , Chaker Layal , Dalm Virgil A. S. H. 
Published: June 2022

IntroductionImmunoglobulins (Igs) play a pivotal role in host defense and prevention of pneumonia. Aging influences serum Ig levels, but the association between Igs and pneumonia in community-dwelling older individuals remains unknown. We evaluated the association of serum IgA, IgG, and IgM with pneumonia and lung function in middle-aged and older individuals.MethodsWe performed Cox and negative binomial regression analyses for the association of Igs with incident pneumonia and pneumonia-related mortality, and recurrent pneumonia respectively. We performed logistic regression analyses for the association between Igs and lung function values. Associations were adjusted for age, sex, smoking, comorbidities, and serum C-reactive protein.ResultsWe included 8,766 participants (median age 62.2 years, 57% women, median follow-up 9.8 years). Higher IgA (hazard ratio [HR]: 1.15; 95% confidence interval [95% CI]: 1.00-1.32) and IgG (HR: 1.13; 95% CI: 1.06-1.19) were associated with an increased pneumonia risk. Higher IgG was associated with an increased risk of pneumonia-related mortality (HR: 1.08; 95% CI: 1.01-1.16) and recurrent pneumonia (incidence rate ratio: 1.04; 95% CI: 1.00-1.09). Higher IgA and IgG were also associated with lower forced expiratory volume in one second (FEV1), lower forced vital capacity (FVC), and an increased odds of preserved ratio impaired spirometry (PRISm, i.e. FEV1 &lt;80% and FEV1/FVC ratio ≥70%). No association was seen with an obstructive spirometry pattern.DiscussionHigher serum IgA and IgG levels were associated with pneumonia, pneumonia-related mortality, and PRISm in middle-aged and older individuals from the general population. Future studies should validate our findings and elucidate underlying pathophysiology.
A Phase I Study of Locoregional High-Dose Autologous Natural Killer Cell Therapy With Hepatic Arterial Infusion Chemotherapy in Patients With Locally Advanced Hepatocellular Carcinoma
Authors: Bae Woo Kyun , Lee Byung Chan , Kim Hyeon-Jong , Lee Je-Jung , Chung Ik-Joo , Cho Sung Bum , Koh Yang Seok 
Published: June 2022

BackgroundTo explore the feasibility and safety of natural killer (NK) cell therapy in HCC, we performed a prospective, open-label, phase I trial to evaluate the synergistic effect of locoregional high-dose autologous NK cell therapy in combination with hepatic arterial infusion chemotherapy (HAIC).MethodsPatients with locally advanced HCC who were refractory to the standard treatment were eligible for this study. Patients received expanded and activated NK cells for 5 consecutive days in a dose-escalating manner (dose 2.5×108, 5×108, 10×108 NK cells/injection) through hepatic arterial infusion following 4 cycles of HAIC with 5-fluorouracil (750 mg/m2) and cisplatin (25 mg/m2). The primary endpoint was the safety of NK cell-based immunotherapy, and the secondary endpoints were objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and immunologic responses.ResultsOf the 11 patients enrolled, the confirmed ORR was 63.6% (complete response [CR]: 36.4%, confirmed partial response [PR]: 27.3%). Stable disease (SD) and progressive disease (PD) were observed in two patients (18.2%) each, resulting in a disease control rate (DCR) of 81.8%. The median PFS and OS were 10.3 and 41.6 months, respectively. There were no incidences of decompensation or severe adverse events during HAIC, and no adverse events related to NK cell infusion were noted.ConclusionThe combination of HAIC and locoregional high-dose NK cell therapy is a safe and effective treatment for locally advanced HCC patients who were refractory to the standard treatment. This result warrants further development of this novel treatment to establish its efficacy in HCC. Clinical Trial Registrationcris.nih.go.kr, identifier KCT0003973.
PET/CT-Based Characterization of 18F-FDG Uptake in Various Tissues Reveals Novel Potential Contributions to Coronary Artery Disease in Psoriatic Arthritis
Authors: Schwartz Daniella M. , Parel Philip , Li Haiou , Sorokin Alexander V. , Berg Alexander R. , Chen Marcus , Dey Amit , Hong Christin G. , Playford Martin , Sylvester McKella , Teague Heather , Siegel Evan , Mehta Nehal N. 
Published: June 2022

Background and ObjectivesPsoriasis is a heterogeneous inflammatory disease that involves the skin, joints, liver, heart, and other organs. Psoriatic arthritis (PsA) is associated with cardiovascular disease (CVD), but the relative contributions of inflammatory and metabolic dysregulation to CVD are incompletely understood. We set out to discover novel potential contributors to CVD in PsA patients by comprehensively phenotyping a cohort of PsA patients using these advanced technologies.MethodsIn this cross-sectional analysis of a cohort study, we investigated associations of systemic inflammation and metabolic dysregulation with Coronary CT angiography (CCTA)-proven coronary artery disease (CAD) in 39 subjects with PsA. We measured traditional CVD risk factors [blood pressure, Body Mass Index (BMI), diabetes, age, sex, smoking], serum markers of systemic inflammation (hsCRP, GlycA) and metabolic dysfunction (cholesterol efflux capacity), and inflammatory cytokines (IL-1β, IL-6, IL-12/IL-23, IL-17A, TNF-α, IFN-γ). We also incorporated radiographic measures of metabolic dysfunction (visceral and subcutaneous adipose volume) and tissue-specific inflammation (positron emission tomography-computed tomography, PET-CT). To quantify relative contributions of FDG (fluorodeoxyglucose) uptake and adiposity to coronary plaque, we performed multiple linear regression, controlling for Framingham risk score (FRS) and FRS + visceral adiposity.ResultsCompared with non-psoriatic volunteers, subjects with PsA had elevated markers of metabolic and inflammatory disease, which was more pronounced in subjects with moderate-to-severe skin disease. This included visceral (p = 0.005) and subcutaneous (p = 0.004) adiposity, BMI (p = 0.001), hemoglobin A1C (p = 0.037), high sensitivity C-reactive protein (p = 0.005), IL-6 (p = 0.003), IFN-γ (p = 0.006), and liver FDG uptake (p = 0.03). In subjects with PsA, visceral adiposity correlated significantly with subclinical CAD (standardized β = 0.681, p = 0.002), as did FDG uptake in bone marrow (standardized β = 0.488, p = 0.008), liver (standardized β = 0.619, p &lt; 0.001), spleen (standardized β = 0.523, p = 0.004), and subcutaneous adipose (standardized β = 0.524, p = 0.003).InterpretationTogether, these findings reveal inflammatory and metabolic potential contributors to subclinical CAD in PsA, including adipose inflammation, and suggesting novel targets for CVD prevention and treatment in PsA.
Prevalence and Prognostic Significance of Liver Fibrosis in Patients With Aneurysmal Subarachnoid Hemorrhage
Authors: Li Tiangui , Wang Peng , Gong Xiao , Chong Weelic , Hai Yang , You Chao , Kang Juan , Fang Fang , Zhang Yu 
Published: June 2022

ObjectivesTo report the prevalence, clinical associations, and prognostic consequences of liver fibrosis in patients with aneurysmal subarachnoid hemorrhage (aSAH).MethodsIn a retrospective study of patients with aSAH, we evaluated three validated liver fibrosis indices and modeled them as continuous-exposure variables, including the aspartate aminotransferase/platelet ratio index (APRI), the fibrosis-4 (FIB-4) index, and the Forns index. The primary outcome was mortality at 90 days. We compared the addition of fibrosis indices to the predictors of the full Subarachnoid Hemorrhage International Trialists model.ResultsA total of 3,722 patients with aSAH were included in the study. According to the APRI, FIB-4 index, and Forns index, 21.7, 17.7, and 11.4% of patients had liver fibrosis. After adjusting for potential confounding factors, liver fibrosis indices were associated with increased 90-day mortality, with odds ratios of 1.35 (95% CI 1.02–1.77) for the FIB-4 index, 1.39 (95% CI.08–1.78) for APRI, and 1.53 (95% CI 1.11–2.12) for the Forns index. Similarly, high liver fibrosis indices were associated with an increased risk of rebleeding. However, the Forns index was not significantly associated with mortality and rebleeding. The addition of FIB-4 indices and APRI into the standard model improved the mortality prediction.ConclusionsLiver fibrosis is common in patients with aSAH, and high liver fibrosis indices are associated with mortality and rebleeding. The addition of liver fibrosis indices to a standard clinical model significantly improves risk stratification.
Comparison of Unilateral Middle Cerebral Artery and Bilateral Middle Cerebral Artery Monitoring for Right-to-Left Shunt Detection by Contrast-Enhanced Transcranial Doppler
Authors: Zhang Wenjie , Yang Le , Wang Shuli , Wang Lin , Li Haixian , Yang Keshi 
Published: June 2022

IntroductionContrast-enhanced transcranial Doppler (c-TCD) is a noninvasive test with high sensitivity for the detection of a right-to-left shunt (RLS). Currently, there are no reports on the outcomes of unilateral versus bilateral middle cerebral artery (MCA) monitoring. This study compared the positivity rate of bilateral MCA monitoring with unilateral MCA monitoring for RLS using c-TCD.MethodsWe enrolled 239 patients (86 women and 153 men) with a mean age of 48.54 ± 13.25 years (range, 14–79 years), who underwent c-TCD examination in the Department of Transcranial Doppler Ultrasound of our hospital between February 2018 and February 2021, due to suspicion of RLS. Bilateral MCA monitoring of 239 patients was performed using dual-channel and dual-depth c-TCD. The positive rate and shunt classification of RLS were calculated for left, right, and bilateral MCA monitoring. The differences in RLS detected by c-TCD monitoring of the left, right and bilateral MCA were compared.ResultsIn the left middle cerebral artery (LMCA) monitoring, 35.56% (85 of 239) had a positive RLS result, 38 cases were permanent (44.70%), and 47 cases were latent (55.30%). In the right middle cerebral artery (RMCA) monitoring, 36.82% (88 of 239) had a positive RLS result, 38 cases were permanent (43.18%), and 50 cases were latent (56.82%). In the bilateral MCA group, 43.09% (103 of 239) had a positive RLS result, 50 cases were permanent (48.54%) and 53 were latent (51.46%). The positive rate of bilateral MCA monitoring was higher than that of LMCA and RMCA (43.09, 35.56, and 36.82%, respectively), and the difference was not statistically significant (P = 0.193). The positive rate of bilateral MCA monitoring was higher than that of LMCA and RMCA for mild and moderate shunts, but the difference was not statistically significant. The positive rate of bilateral MCA monitoring was equal to that of RMCA, but higher than that of LMCA, with no statistical significance. LMCA monitoring revealed 85 patients with RLS. The sensitivity was 82.52% (85/103). The specificity was 100%. The RMCA monitoring results showed 88 cases with RLS. The sensitivity was 85.44% (88/103). The specificity was 100%.ConclusionsThere was no significant difference in the RLS detection rate between unilateral and bilateral MCA monitoring using c-TCD. Bilateral MCA monitoring may be more advantageous for mild RLS detection.
Increased Resting-State Functional Connectivity of the Hippocampus in Rats With Sepsis-Associated Encephalopathy
Authors: Yao Yue , Lu Chunqiang , Chen Jiu , Sun Jie , Zhou Cuihua , Tan Cheng , Xian Xian , Tong Jianhua , Yao Hao 
Published: June 2022

BackgroundSepsis-associated encephalopathy (SAE) has been identified as a frequent complication of sepsis, featured by an aberrant level of cognitive and affective functions. The present study is designed to explore the changes in functional connectivity (FC) of the hippocampus in rats with SAE utilizing resting-state functional magnetic resonance imaging (rs-fMRI).MethodsSprague-Dawley rats were randomly assigned to the SAE and control groups. We acquired rs-fMRI data using a 7T MRI to evaluate hippocampal network functional differences between the two groups with a seed-based approach. Behavioral performance was assessed using the open field test and forced swimming test. Statistical analysis was undertaken to evaluate the correlation between the hippocampal FC and behavioral findings.ResultsCompared with the control group, the SAE group showed increased FC between the bilateral hippocampus and thalamus, septum, bed nuclei stria terminalis (BNST), left primary forelimb somatosensory cortex (S1FL), primary motor cortex (M1), and inferior colliculus. Increased FC between the left hippocampus and thalamus, septum, BNST, left S1FL, and inferior colliculus was observed. While with the right hippocampus, FC in thalamus, septum, left S1FL and inferior colliculus was enhanced. Additionally, positive correlations were found between the hippocampal FC and the immobility time in the forced swimming test.ConclusionHippocampus-related brain networks have significant alterations in rats with SAE, and the elevated hippocampal resting-state FC was positively related to affective deficits. Changes in FC between the hippocampus and other brain regions could be a potential neuroimaging biomarker of cognitive or mental disorders triggered by SAE.
Cause of Death During Renal Cell Carcinoma Survivorship: A Contemporary, Population-Based Analysis
Authors: Yu Dong-Dong , Chen Wei-Kang , Wu Chen-Yu , Wu Wan-Ting , Xin Xiao , Jiang Yu-Li , Li Peng , Zhang Ming-Hua 
Published: June 2022

BackgroundAs the survival rates of patients with renal cell carcinoma (RCC) continue to increase, noncancer causes of death cannot be ignored. The cause-specific mortality in patients with RCC is not well understood.ObjectiveOur study aimed to explore the mortality patterns of contemporary RCC survivors.MethodsWe performed a retrospective cohort study involving patients with RCC from the Surveillance, Epidemiology, and End Results (SEER) database. We used standardized mortality ratios (SMRs) to compare the death rates in patients with RCC with those in the general population.ResultsA total of 106,118 patients with RCC, including 39,630 who died (27%), were included in our study. Overall, compared with the general US population, noncancer SMRs were increased 1.25-fold (95% confidence intervals [CI], 1.22 to 1.27; observed, 11,235), 1.19-fold (95% CI, 1.14 to 1.24; observed, 2,014), and 2.24-fold (95% CI, 2.11 to 2.38; observed, 1,110) for stage I/II, III, and IV RCC, respectively. The proportion of noncancer causes of death increased with the extension of survival time. A total of 4,273 men with stage I/II disease (23.13%) died of RCC; however, patients who died from other causes were 3.2 times more likely to die from RCC (n = 14,203 [76.87%]). Heart disease was the most common noncancer cause of death (n = 3,718 [20.12%]; SMR, 1.23; 95% CI, 1.19–1.27). In patients with stage III disease, 3,912 (25.98%) died from RCC, and 2,014 (13.37%) died from noncancer causes. Most patients (94.99%) with stage IV RCC died within 5 years of initial diagnosis. Although RCC was the leading cause of death (n = 12,310 [84.65%]), patients with stage IV RCC also had a higher risk of noncancer death than the general population (2.24; 95% CI, 2.11–2.38).ConclusionsNon-RCC death causes account for more than 3/4 of RCC survivors among patients with stage I/II disease. Patients with stage IV are most likely to die of RCC; however, there is an increased risk of dying from septicemia, and suicide cannot be ignored. These data provide the latest and most comprehensive assessment of the causes of death in patients with RCC.