bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface Decoration of Peptide Nanoparticles Enables Efficient Therapy toward Osteoporosis and Diabetes
Authors: Huang Tianhe , Wang Guan , Shahbazi Mohammad‐Ali , Bai Yuancheng , Zhang Jingrui , Feng Guobing , Asadian Elham , Ghorbani‐Bidkorpeh Fatemeh , Yang Zhiyuang , Li Yuanai , Huo Qingqing , Liu Yingxin , Liu Dongfei 
Published: November 2022

AbstractA versatile surface decoration strategy to efficiently encapsulate water‐soluble peptides is developed. By assembling peptide molecules into nanoparticles, diverse physiochemical properties of these compacted molecules are equalized to the surface properties of nanoparticles. Primarily driven by the generic electrostatic attractions, the surface of as‐prepared peptide nanoparticles is decorated with charged amino acids‐grafted poly(lactic‐co‐glycolic acid). This adsorbed polymer layer versatilely blocks the phase transfer of peptide nanoparticles by increasing their affinity to the dispersed phase solvent molecules. Attributed to the ultrahigh encapsulation efficiencies (> 96%), the peptide mass fraction inside the obtained microcomposites is higher than 48%. The plasma calcium level has been efficiently reduced for ≈3 weeks with only one single injection of salmon calcitonin‐encapsulated microcomposite in osteoporotic rats. Similarly, one single injection of exenatide‐encapsulated microcomposites efficiently controls the glycemic level in type 2 diabetic rats for up to 3 weeks. Overall, the developed versatile surface decoration strategy efficiently encapsulates peptides and improves their pharmacokinetic features, regardless of the molecular structure of peptide cargos.
Food security status in seniors over their life course
Authors: Pezzia Carla , Rogg Magda C. , Leonard Tammy 
Published: November 2022

AbstractWe examine the life stories of 107 low‐income older adults to assess critical points in which to intervene and potentially prevent senior food insecurity. Participants were recruited from various social service agencies throughout Dallas county. They were asked about life experiences, food insecurity, economic hardships, and health challenges. We utilized qualitative (thematic and content) and quantitative (bivariate and multiple regression) analyses. Our data suggest that vulnerable seniors often experience multiple hardships simultaneously, which play off one another and create tradeoffs. These hardships sometimes pose barriers to receiving assistance. Prior experiences of hardship also modify expectations of hardships in older adulthood.
Synthesis and evaluation of epoxidized vegetable oleic acid as a novel environmental benign plasticizer for polyvinyl chloride
Authors: Feng Shan , Jiang Pingping , Zhang Pingbo , Lu Minjia , Cui Zhixuan , Pan Jie , Pan Lingen 
Published: November 2022

AbstractA bio‐based plasticizers, acetyl‐oleate triethylene glycol (AOT), was successfully synthesized by using oleic acid as a raw material through esterification, epoxidation, and acetylation. Its structure was analyzed by Fourier transform infrared spectroscopy and 1H nuclear magnetic resonance. The plasticizing performances of this plasticizer was compared with those of two commercial ones: dioctyl terephthalate (DOTP) and dioctyl adipate (DOA). This was done by blending these plasticizers with PVC, respectively. Thermal gravimetric analysis results showed that the 5% weight loss temperature of PVC with AOT was 53°C higher than that of DOA and 36°C higher than that of DOTP. The tensile results showed that the AOT plasticized PVC had excellent stretchability: its elongation at break with 50 phr AOT reached 697.7%. Furthermore, its transmittance was as high as 90%, showing better compatibility of ATO with PVC.
Effect of hardener and catalyst contents on curing and degradation of epoxidized soybean oil
Authors: Albuquerque Ananda K. C. , Almeida Débora E. O. , Barreto José V. M. , Silva Ingridy D. S. , Jaques Nichollas G. , Nepomuceno Neymara C. , Medeiros Eliton S. , Wellen Renate M. R. 
Published: November 2022

AbstractEpoxidized soybean oil (ESO) compounds were cured with methyl tetrahydrophthalic anhydride (MTHPA) as hardener and 2,4,6‐tris (dimethylaminomethyl) phenol (DEH 35) as catalyst. To figure out MTHPA and DEH 35's influence during curing and degradation, ESO/MTHPA/DEH 35 compounds were investigated using Fourier‐Transform Infrared Spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermogravimetry (TG). FTIR spectra of uncured resin showed the secondary interactions among ESO's carbonyl groups with MTHPA and DEH 35's hydroxyls and amines. Curing progress was followed tracking the evolution of reactive groups, that is, epoxy and carbonyl bands and corroborated with released heat of DSC scans. ESO 87:5 and ESO 87:10 compounds cured using higher heating rates presented higher released enthalpy suggesting denser reticulation, and they also displayed lower activation energy for curing, which was evaluated using the Friedman model. Increasing the hardener and catalysts contents promoted higher thermal stability and lower degradation rates, while higher for degradation was verified.
Effect of the temperature of the heat treatment of pine wood on subsequent in situ polymerization with poly(methyl methacrylate)
Authors: Acosta Andrey P. , Diaz René H. , Amico Sandro C. , Beltrame Rafael , Barbosa Kelvin T. , Delucis Rafael A. , Gatto Darci A. 
Published: November 2022

AbstractThe objective of this study was to evaluate a two‐step Pinus elliottii modification process comprising thermal treatment at different temperatures (180 °C, 200 °C, or 220 °C) for 2 h followed by vacuum‐pressure treatment and in situ polymerization with a highly pure solution of poly (methyl methacrylate) (PMMA). The treated samples were then characterized based on weight loss, weight gain, density, Fourier transform infrared spectroscopy, chemical constituents, thermal stability, dimensional stability, surface hydrophobicity, morphology, color changes, and mechanical properties. Thermal modification prior to impregnation increased thermal stability (~100%–150%) in comparison with heat‐treated pine wood. Furthermore, after the two‐step treatment, the color presented similar patterns and a lower level of water uptake (~40%–60%). Post‐treatment with PMMA recovered the losses in both stiffness and strength brought by thermal modification at 180 °C and 200 °C; however, the treatment at 220 °C was found to be unsuitable for the two‐step process. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
The efficacy of anti‐proteolytic peptide R7I in intestinal inflammation, function, microbiota, and metabolites by multi‐omics analysis in murine bacterial enteritis
Authors: Sun Taotao , Liu Xuesheng , Su Yunzhe , Wang Zihang , Cheng Baojing , Dong Na , Wang Jiajun , Shan Anshan 
Published: November 2022

AbstractIncreased antibiotic resistance poses a major limitation in tackling inflammatory bowel disease and presents a large challenge for global health care. Antimicrobial peptides (AMPs) are a potential class of antimicrobial agents. Here, we have designed the potential oral route for antimicrobial peptide R7I with anti‐proteolytic properties to deal with bacterial enteritis in mice. The results revealed that R7I protected the liver and gut from damage caused by inflammation. RNA‐Seq analysis indicated that R7I promoted digestion and absorption in the small intestine by upregulating transmembrane transporter activity, lipid and small molecule metabolic processes and other pathways, in addition to upregulating hepatic steroid biosynthesis and fatty acid degradation. For the gut microbiota, Clostridia were significantly reduced in the R7I‐treated group, and Odoribacteraceae, an efficient isoalloLCA‐synthesizing strain, was the main dominant strain, protecting the gut from potential pathogens. In addition, we further discovered that R7I reduced the accumulation of negative organic acid metabolites. Overall, R7I exerted better therapeutic and immunomodulatory potential in the bacterial enteritis model, greatly reduced the risk of disease onset, and provided a reference for the in vivo application of antimicrobial peptides.
Layered manganese phosphorus trisulfides for high‐performance lithium‐ion batteries and the storage mechanism
Authors: Shen Hailin , Cai Yueling , Ma Zhongtao , Wang Peng , Guo Bingkun , Cheng Jipeng , Li Qianqian , Wang Hongtao , Liu Zhongyuan , Nie Anmin , Wu Jinsong 
Published: November 2022

AbstractAlthough advanced anode materials for the lithium‐ion battery have been investigated for decades, a reliable, high‐capacity, and durable material that can enable a fast charge remains elusive. Herein, we report that a metal phosphorous trichalcogenide of MnPS3 (manganese phosphorus trisulfide), endowed with a unique and layered van der Waals structure, is highly beneficial for the fast insertion/extraction of alkali metal ions and can facilitate changes in the buffer volume during cycles with robust structural stability. The few‐layered MnPS3 anodes displayed the desirable specific capacity and excellent rate chargeability owing to their good electronic and ionic conductivities. When assembled as a half‐cell lithium‐ion battery, a high reversible capacity of 380 mA h g−1 was maintained by the MnPS3 after 3000 cycles at a high current density of 4 A g−1, with a capacity retention of close to or above 100%. In full‐cell testing, a reversible capacity of 450 mA h g−1 after 200 cycles was maintained as well. The results of in‐situ TEM revealed that MnPS3 nanoflakes maintained a high structural integrity without exhibiting any pulverization after undergoing large volumetric expansion for the insertion of a large number of lithium ions. Their kinetics of lithium‐ion diffusion, stable structure, and high pseudocapacitance contributed to their comprehensive performance, for example, a high specific capacity, rapid charge–discharge, and long cyclability. MnPS3 is thus an efficient anode for the next generation of batteries with a fast charge/discharge capability.
Development of a Single‐Use Device and an Associated Optical Measurement Method for Automated Magnetic Bioseparation
Authors: Wommer Lars , Barth Isabelle , Ulber Roland , Kampeis Percy 
Published: November 2022

AbstractIn bioseparation, magnetic particles can be used for the adsorption of biomolecules. They can be selectively separated from multi‐component suspensions with high‐gradient magnetic separation (HGMS). A single‐use HGMS separation chamber has been developed to avoid cross‐contamination. As with fixed‐bed adsorption, breakthrough occurs after a certain time. Subsequently, the magnetic particles that are then still further fed, are lost together with the biomolecules bound to them. In order to stop the HGMS process before breakthrough, an associated optical measurement method was developed.
Easy Structural Dereplication of Natural Products by Means of Predicted Carbon‐13 Nuclear Magnetic Resonance Spectroscopy Data**
Authors: Kuhn Stefan , Nuzillard Jean‐Marc 
Published: November 2022

AbstractThe present article reports the creation and usage of a general natural product database for the structural dereplication of natural products. This database, acd_lotusv7, derives from the LOTUS natural products database as the sole source of chemical structures. Database construction also relies on the commercial “ACD/C+H Predictors and DB” software for the prediction of the carbon‐13 nuclear magnetic resonance (NMR) spectral data associated with structures. The linkage of each natural compound with a Wikidata resource identifier already present in LOTUS accelerates the access to the primary literature data such as biologic origin and bibliographic references. The open source nmrshiftdb2 web interface and search engine provide a simple and free way to retrieve compound structures stored in acd_lotusv7 from carbon‐13 data and to analyze search results. Dereplication is illustrated by the easy and free retrieval of the structure of three natural compounds of low, medium, and high complexity from published lists of carbon‐13 NMR chemical shifts.
DRA‐MQoS: AnMQoSscheduling algorithm based on resource feature matching in federated edge cloud
Authors: Li Yujin , Liu Bo , Wu Enju , Li Jianqiang , Zhou Zhangbing , Zhang Wenbo 
Published: November 2022

SummaryFederated edge cloud (FEC) is an edge computing environment where servers in the same edge management domain could collaborate to handle latency‐sensitive services, thus better guaranteeing users' requirements on multiple quality of service (MQoS). Traditional scheduling methods only consider whether the server meets the resource requirements of the service, without paying attention to whether their resource characteristics match. In scenarios where server's resources are dynamically changing, this may reduce the resource utilization and the efficiency of service execution. To address this challenge, a dynamic resource adaptation‐multiple quality of service (DRA‐MQoS) algorithm is proposed for service scheduling in this environment. DRA‐MQoS could dynamically evaluate the resource characteristics of servers and services from the perspectives of “individual” and “overall” by combining the historical scheduling data of services and the utilization of different resources of server clusters. By scheduling the services to servers with the same resource characteristics for execution, the proposed policy fusion algorithm efficiently responds to the dynamically changing quality of service (QoS) demands of users by changing the weight parameters of policies. Simulation results in CloudSimSDN show that the energy consumption and execution time of DRA‐MQoS are reduced by 23% and 12%, respectively, compared with existing methods.
A Phosphine‐ß‐diketiminate Nickel(I)‐Complex for Small Molecule Activation
Authors: Zovko Christina , Krätschmer Frederic , Schmidt Sarah , Seifert Tim P. , Gamer Michael T. , Roesky Peter W. 
Published: November 2022

AbstractA bis(diphenyl)‐phosphine functionalized ß‐diketimine ligand (PNac‐H) was applied for the synthesis of a subvalent Ni(I) complex [PNac‐Ni]. Here, the Ni(I) center is stabilized by a tetradentate PNNP‐type pocket, forming a square planar coordination sphere. Subsequently, the Ni(I) complex was investigated with regard to its reactivity and the activation of small molecules. The reductive potential of Ni(I) enabled an activation of different substrate classes, such as CH2X2 (X=Br, I), I2 or Ph2E2 (E=S, Se). The ligand's design allows a stabilization of the reactive Ni(I) species while at the same time enabling activation processes due to a hemilabile coordination behavior and accessible axial coordination sites. The activation products have been characterized by single crystal X‐ray diffraction, NMR and IR spectroscopy as well as elemental analysis.
How to use experience‐sampling technology to understand daily functioning: A practical guide for mental health professionals
Authors: Daniëls Naomi E. M. , Verhagen Simone J. W. , van Bokhoven Marloes A. , Beurskens Anna J. , Delespaul Philippe A. E. G. 
Published: November 2022

AbstractSatisfying daily life functioning is essential in mental healthcare. Standard assessments focus on symptoms and are designed to detect underlying vulnerabilities. However, they offer insufficient insight into patterns of contextual variability and resilience. Consequently, interventions are planned using incomplete information. The experience‐sampling method (ESM) is a structured moment‐to‐moment diary assessing the individual's affect, thoughts, perception and behaviour in the daily life context. ESM helps to understand variation in mental states (e.g., anxiety or sleeping problems) as adaptational processes in relation to contextual challenges (functional analysis). Although ESM has been extensively studied across psychological disorders, the adoption by mental health professionals and their patients remains limited because the ‘how to’ is unclear. This paper presents a practical guide for ESM application in routine clinical care. It integrates empirical knowledge with expert experiences and provides real‐world examples and recommendations for successful implementation. The guide comprises how to engage and motivate patients and how to customize assessments to the patient's needs. It also includes instructions to interpret results and create an atmosphere of shared decision‐making. Experience‐sampling technology has merits for patients with various mental health complaints and across healthcare settings, although the exact use and implementation may vary depending on the individual case.
Expression levels and patterns of B‐cell maturation antigen in newly diagnosed and relapsed multiple myeloma patients from Indian subcontinent
Authors: Sriram Harshini , Kunjachan Florence , Khanka Twinkle , Gawai Sangamitra , Ghogale Sitaram , Deshpande Nilesh , Girase Karishma , Patil Jagruti , Chatterjee Gaurav , Rajpal Sweta , Patkar Nikhil V. , Bagal Bhausaheb , Jain Hasmukh , Sengar Manju , Hasan Syed Khizer , Khattry Navin , Subramanian Papagudi G. , Gujral Sumeet , Tembhare Prashant R. 
Published: November 2022

AbstractBackgroundMany novel therapies are being evaluated for the treatment of Multiple myeloma (MM). The cell‐surface protein B‐cell maturation antigen (BCMA, CD269) has recently emerged as a promising target for CAR‐T cell and monoclonal‐antibody therapies in MM. However, the knowledge of the BCMA expression‐pattern in myeloma patients from the Indian subcontinent is still not available. We present an in‐depth study of BCMA expression‐pattern on abnormal plasma cells (aPC) in Indian MM patients.MethodsWe studied BM samples from 217 MM patients (211‐new and 6‐relapsed) with a median age of 56 years (range, 30–78 years & M:F‐2.29) and 20 control samples. Expression levels/patterns of CD269 (clone‐19f2) were evaluated in aPCs from MM patients and in normal PCs (nPC) from uninvolved staging bone marrow samples (controls) using multicolor flow cytometry (MFC). Expression‐level of CD269 was determined as a ratio of mean fluorescent intensity (MFI‐R) of CD269 in PCs to that of non‐B‐lymphocytes and expression‐pattern (homogenous/heterogeneous) as coefficient‐of‐variation of immunofluorescence (CVIF).ResultsMedian (range) percentage of CD269‐positive abnormal‐PCs in total PCs was 71.6% (0.49–99.29%). The MFI‐R (median, range) of CD269 was significantly higher in aPCs (4.13, 1.12–26.88) than nPCs (3.33, 1.23–12.87), p < .0001. Median (range) MFI of CD269 at diagnosis and relapse were 2.39 (0.77–9.57) and 2.66 (2.15–3.23) respectively. CD269 levels were similar at diagnosis and relapse, p = .5529.ConclusionsWe demonstrated that BCMA/CD269 is highly expressed in aPCs from a majority of MM patients, both at diagnosis and relapse. Thus, BCMA is a valuable target for therapy for Indian MM patients.
Experimental investigation on maximizing conveying efficiency of belt conveyors used in series application and estimation of power consumption through statistical analysis
Authors: Jena Madhab Chandra , Mishra Sarat Kumar , Moharana Himanshu Sekhar 
Published: November 2022

AbstractIn this research work, different parameters have been studied which affect the energy consumption of belt conveyors. The effect of conveying distance and vertical lift on energy consumption was studied in detail by collecting energy consumption and other associated data of belt conveyors from different cement plants and analyzed with the help of different statistical analysis. The highest specific energy consumption was found to be 0.0011 kWh/Ton‐m in the smallest belt conveyor of 15 m and the lowest specific energy consumption was found to be 0.0007 kWh/Ton‐m in the longest belt conveyor of 100 m. Specific energy consumption is reduced up to 36% per ton‐meter of material conveying in the longest belt conveyor compared with the smallest belt conveyor. On the contrary, the specific energy consumption for different vertical lifts is found almost the same. Hence, it can be suggested that for horizontal conveying, the series of belt conveyors should be replaced with a single long conveyor to achieve maximum conveying efficiency and to lower specific energy consumption. The above study will be helpful for heavy industries such as cement plants, steel plants, and so forth to reduce their energy consumption on belt conveyors and achieve the environmental sustainability goals. At the last part of the study an equation is derived for estimating energy consumption in belt conveyors by applying multiple regression analysis. The proposed equation will be helpful for estimation of energy consumption of belt conveyors according to which the decision for conveyor length can be taken.
Psychometric properties of the Autonomic Symptoms Checklist in the Lewy body disease module of the uniform dataset
Authors: Waters Abigail B. , Williamson John B. , Kiselica Andrew M. 
Published: November 2022

AbstractIntroductionAutonomic dysfunction is an important feature of Lewy Body Dementia (DLB), but measurement of autonomic symptoms has been limited in both previous research and clinical practice. Accurate measurement of autonomic dysfunction has the potential to improve our understanding of the course and progression of DLB, given that autonomic symptoms typically precede cognitive impairment and are associated with functional impairment. The primary aim of this study was to examine the psychometric properties of the two versions (3.0 and 3.1) of the NACC LBD‐module Autonomic Symptom Checklist (ASC).MethodsPsychometric analyses of the ASC (internal consistency, reliability, factor structure, and validity) were conducted on data acquired from 245 individuals with DLB from the NACC database. ASC V3.0 was contrasted on these attributes to V3.1.ResultsResults suggested an underlying factor structure for the ASC, and confirmatory factor analysis (CFA) revealed 3 factors, which generally aligned with discrete autonomic systems. The ASC V3.0 and CFA‐identified scales were comparable in terms of reliability, which were both improved relative to the ASC V3.1. In terms of ecological validity, CFA‐identified items related to gastrointestinal/thermoregulation symptoms were significantly more associated with functional outcomes compared to the unitary ASC.ConclusionFindings underscore the importance of differentiation within the autonomic system. Future research into autonomic symptom classes and lab‐based pathophysiological measurement of autonomic dysfunction in DLB has the potential to support early identification and inform treatment planning.