bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing osteoporosis management: targeting to treat — an initiative by the Egyptian Academy of Bone Health
Authors: El Miedany Yasser , Gadallah Naglaa Ali , Toth Mathias 
Published: November 2022

AbstractThe overarching goal of treating osteoporotic patients is to reduce the incidence of fractures, yet interventions that support early detection of osteoporosis and prevention of osteoporotic fractures are underutilized. Osteoporosis and, specifically, the associated burden of fractures call for a screening strategy offering an opportunity to intervene early. Such strategy should be clinically feasible and cost-effective, aiming to identify and treat subjects at high or very high risk of fragility fracture.The low sensitivity of bone mineral density measurements in identifying high-risk patients is evidenced by the high number of osteoporotic fractures occurring in subjects with BMD values above threshold required for a diagnosis of osteoporosis. Consequently, DXA scanning is not considered appropriate as a public screening tool identifying patients at risk of sustaining fragility fractures and current efforts focus on identifying non-BMD-related risk factors.In Egypt, we are fortunate in having all modalities of osteoporosis therapy and assessment tools available, yet there remains a significant treatment gap in osteoporosis management. Furthermore, screening for fracture risk is not currently advocated nationally. This manuscript describes a national initiative for a population screening intervention to identify patients at risk of developing a fragility fracture aiming to reduce fragility fractures especially in older adults.
Digital literacy in contemporary mental healthcare: electronic patient records, outcome measurements and social media
Authors: Tracy Derek K. , Gadelrab Romayne , Rahim Ayesha , Pendlebury Gabrielle , Reza Hashim , Bhattacharya Rahul , Bachlani Asif , Worlley Katherine , Rigby David , Scott Jonathan , Dave Subodh 
Published: November 2022

SUMMARYDigital psychiatry has become increasingly important and understanding of certain aspects is essential for practising clinicians. This article discusses electronic patient records (EPRs), from their origins to current and future use, the growth and embedding of outcome measurements, the use of social media, and learning and research in virtual arenas.
Mediators of quality of life change in people with severe psychotic disorders treated in integrated care: ACCESS II study
Authors: Schröter Romy , Lambert Martin , Rohenkohl Anja , Kraft Vivien , Rühl Friederike , Luedecke Daniel , Gallinat Jürgen , Karow Anne , Schmidt Stefanie J. 
Published: November 2022

Abstract

Background
Patients with severe psychotic disorders exhibit a severely reduced quality of life (QoL) at all stages of the disease. Integrated care often led to an improvement in QoL. However, the specific mediators of QoL change are not yet well understood.

Methods
The ACCESS II study is a prospective, long-term study investigating the effectiveness of an integrated care program for people with severe psychotic disorders (IC-TACT) that includes Therapeutic Assertive Community Treatment within a care network of in- and outpatient services at the University Medical Center Hamburg-Eppendorf, Germany. We examined longitudinal associations between QoL and the hypothesized mediators of change (i.e., negative symptoms, depression, and anxiety), using cross-lagged panel models.

Results
The sample includes 418 severely ill patients treated in IC-TACT for at least 1 year. QoL increased, whereas symptom severity decreased significantly from baseline to 6-month follow-up (p-values ≤ 0.001), and remained stable until 12-month follow-up. QoL and symptom severity demonstrated significant auto-correlated effects and significant cross-lagged effects from QoL at baseline to negative symptoms (6 months, β = −0.20, p < 0.001) to QoL (12 months, β = −0.19, p < 0.01) resulting in a significant indirect, mediated effect. Additionally, negative symptoms after 6 months had a significant effect on the severity of depression after 12 months (β = 0.13, p < 0.05).

Conclusions
Negative symptoms appear to represent an important mechanism of change in IC-TACT indicating that improvement of QoL could potentially be achieved through optimized intervention on negative symptoms. Moreover, this may lead to a reduction in the severity of depression after 12 months.
Patterns of Treatment and Outcomes in Epithelial Ovarian Cancer: A Retrospective North Indian Single-Institution Experience
Authors: Meena Rajendra Kumar , Syed Nisar Ahmad , Sheikh Zahoor Ahmad , Guru Faisal Rashid , Mir Mohmad Hussain , Banday Saquib Zaffar , MP Arun Krishnan , Parveen Shaheena , Dar Nazir Ahmad , Bhat Gull Mohammad 
Published: November 2022

PURPOSEOvarian cancer (OC) is ranked as the third most common gynecologic cancer in various Indian cancer registries. In India, OC is seen in the younger age group, with a median age < 55 years being reported by most of the studies. The majority of patients are diagnosed in advanced stage (70%-80%), where the long-term (10-year) survival rate is poor, estimated at 15%-30%. The aim of this study was to evaluate clinical epidemiology, treatment patterns, and survival outcomes in patients with epithelial OC.METHODSThis was a retrospective analysis of patients with epithelial OC who were treated at Sher-i-Kashmir Institute of Medical Sciences, Srinagar, over a period of 9 years, from January 2010 to December 2018.RESULTSOC constituted 2.94% of all cancers registered. Epithelial OC constituted 88.4% of all OCs, with a median age 50 years. More than two third of patients belonged to rural background and the majority (76.9%) of the patients were in stage III or IV at the time of diagnosis. The main presenting symptoms were abdominal distension/bloating (46.5%) and gastrointestinal disturbances (35.2%). The most common histologic types were serous (65.9%) followed by mucinous carcinoma (15%). Median overall survival for the whole study cohort was 30 months (95% CI, 28.0 to 31.9). Median overall survival for stage I, II, III, and IV was 72, 60, 30, and 20 months, respectively.CONCLUSIONMost of the patients presented in advanced stage of the disease and have poor outcome. Delay in diagnosis and improper management before registering in tertiary cancer center and lack of tertiary care facilities are the root causes of poor outcomes. The general population and primary care physicians need to be made aware of OC symptoms.
Juyong Gate
Authors: Cho Yong 
Published: November 2022

Abstract
In 1345 the Mongol ruling house of the Yuan (1271–1368) built Juyong Gate along China's Great Wall. The gate stood on a road connecting the empire's twin capitals, Dadu and Shangdu. Those two cities possessed vastly different built environments. Dadu, the emperor's winter residence, evoked the tradition of Chinese imperial-city building. It provided the ruler with wooden and stone buildings laid out on an orthogonal grid. Shangdu, the emperor's summer residence, delivered a space for grassland containing pastures, where the ruler could set up collapsible tents filled with wall hangings. In other words, the seasonal movement between the two capitals entailed a shift in the habit of seeing and visual representation. To reflect that shift, Juyong Gate's passageway was carved with imagery that could simultaneously belong to the two visual worlds: planar reliefs that could be perceived as both stone carvings and wall hangings. Juyong Gate thus became a site where two major visual systems in constant negotiation in the Mongols' China could come together and coexist as one.
Digital Juneteenth: Territorializing the Freedom Colony Diaspora
Authors: Roberts Andrea , Aduen Valentina , Blanks Jennifer , Carter Schuyler , Girault Kendall 
Published: November 2022

AbstractAfter Juneteenth, formerly enslaved African Americans in Texas founded hundreds of historic Black settlements known as freedom colonies. Later, freedom colonies’ populations dispersed, physical traces disappeared, and memories of locations vanished as descendants passed away. In the absence of buildings and legally recognized borders, intangible heritage—stories, ephemeral traditions—define a sense of place. Betraying the perception that these places have disappeared, founders’ descendants express commitments to freedom colonies by returning periodically to plan commemorative events, rehabilitate historic structures, and steward cemeteries. The Texas Freedom Colonies Project (The TXFC Project), a team of faculty and student researchers, documents settlements while supporting descendant communities’ historic preservation aims. By making diasporic publics legible and increasing the visibility of communities’ settlement patterns and remaining extant features, The TXFC Project elevates stakeholders’ concerns in urban planning domains. In 2020, COVID-19’s social distancing requirements challenged diasporic descendants’ efforts to foster social cohesion. Consequently, The TXFC Project hosted a Facebook Live “talk show,” leveraging social media platforms to amplify freedom colony descendants’ work. The team analyzed event transcripts revealing cultural adaptations to socially restrictive conditions during Juneteenth commemorations and indicating that virtual storytelling helped territorialize widely dispersed, unbounded places for stakeholders facing natural and human-made disruptions.
“Housing Is a Human Right”
Authors: Overholt M. C. 
Published: November 2022

AbstractIn the midst of the global SARS-CoV-2 epidemiological crisis unfolds another contagion: the eviction epidemic. This essay attends to the work of Moms for Housing, an organization of formerly homeless and marginally housed Black mothers in Oakland, California who have organized to confront dispossession, real-estate speculation, and the privatization of housing. Using Black feminist and queer of color intellectual frameworks as ciphers through which to interpret and properly attribute weight to the organization's activism, the essay argues that Moms for Housing not only offers potential flightlines toward a post-property future—one in which housing is positioned as a basic human right—but also a generative critique of the home as a site of racialized and gendered subject formation. Indeed, through their work, the reconception of kinship formation and territorial formation are understood to be mutually constitutive, abolitionist projects.
Governance Interface: The Index in Modi's India
Authors: Samdub Mila 
Published: November 2022

AbstractIn Modi's India, a host of indices perform transparency, efficiency, and good governance but leave undeclared the political shifts they are bringing about. Dramatized in real-time dashboards, policy briefs, press reports, and social media posts, these technocratic numbers arbitrarily rank administrative units and place them in a competitive relation with each other within Indian federalism. As technical device, aesthetic projection, and mediating interface, the index is a node in “maximum governance,” an emergent apparatus of governance that renders development as the site of a pernicious combination of centralizing state power and neoliberal entrepreneurship.
Pandemic changes in work, rest, physical activity and diet versus nutritional status of respondents
Authors: Jawień Wiktoria , Kania Barys Barbara , Kądziołka Anna , Jurkiewicz Beata 
Published: November 2022

The aim of the study was to determine how the COVID-19 pandemic affected the nutritional status of the respondents through changes in work mode, physical activity and diet among residents of the Tarnów region.
Material and methods. The study was conducted using the diagnostic survey method, and the tool was the author's questionnaire. The study was conducted in January-February 2022, using the Google Forms platform. In total, data were collected from 414 people. The questionnaires were filled out mostly by women (67.9% vs. 32.1%). The average age of respondents was 31.9 years (±13.52).
Results. Those who worked remotely and in hybrid mode had the highest percentages declaring an increase in food intake during the COVID-19 pandemic (65.0% and 59.7%, respectively). The highest percentages of those who indicated a deterioration in the quality of their food intake were those who worked remotely (60.0%) and hybrid job (45.5%), while those who did not work were the group that most often among the others indicated an improvement in the quality of their food (23.4%). Respondents with remote and hybrid jobs were the most likely to report a reduction in their activity level (72.5% and 58.4%, respectively). Considering the BMI of those surveyed before the COVID-19 pandemic and now, there is an apparent decrease in the percentage of those with a normal BMI in favor of overweight and obesity.
Conclusions. During the COVID-19 pandemic period, the percentages of overweight and obese people increased. People working remotely and in hybrid mode not only increased the amount of food they consumed, but also began to consume lower-quality products, as well as more often reporting reduced levels of physical activity.
Clinical significancy of WNT pathway inhibition in various cancers
Authors: Rogaczewski Patryk , Janiak Michał , Borysewicz Kamil , Głos Tadeusz , Ahmadi Navid , Szylberg Łukasz 
Published: November 2022

The tumor microenvironment (TME) plays an important role in the cell cycle. There is a correlation between the Wnt/B–catenin signaling pathway and TME. This article reviews methods of inhibiting Wnt Pathway, a useful process in the treatment of various cancers. Compounds of Wnt/β–Catenin Signaling Pathway, such as TCF–1, have an impact on the differentiation and migration of CD8+ T cells. CCL4 expression is regulated by the beta–catenin protein to recruit CD103+ dendritic cells, which enables CD8+ T cell activation. Inhibition of the Wnt/β–catenin pathway has an impact on ovarian cancer patients’ prognosis, reducing the development of ovarian cancer. Research shows that inhibition of the pathway with the use of the LGK974 inhibitor may boost immunity, especially when applied with a Paclitaxel mix. After treatment, expression of the inhibitory receptors CTLA–4, TIM3, PD–1 on CD8+ T cells decreased. The combination of LGK974 and Paclitaxel can cause the death of tumor cells and significantly inhibit their proliferation. The application of dose–dense Paclitaxel avoids toxicity related to the maximum dose needed to protect the patient's immune system by increasing CD8+ TILs. There are concerns regarding toxicity of the LGK 974, especially for cells dependent on the Wnt/β–catenin pathway to maintain homeostasis. Many Wnt/β–catenin pathway inhibitors are tested against colorectal cancer (CRC) with successful results. These include NSAIDs, porcupine inhibitors, tankyrase inhibitors, Wnt5A inhibitors, and disheveled protein inhibitors.The Wnt/β–catenin pathway, when expressed in Triple Negative Breast Cancer (TNBC), leads to the transition of epithelial to mesenchymal cells. In early clinical development, there are multiple inhibitors (ex. KYA1797K) targeting the Wnt/β–catenin pathway in TNBC cells, which could become a viable anticancer strategy.
Processo de trabalho do profissional de Educação Física na atenção básica em territórios do campo
Authors: Lima Fernando de , Almeida Maria Deisyelle Sibaldina da Silva , Melo Taynara Poliana Gonçalves de , Rodrigues Junior Wellington da Silva , Da Silva Nicole Caroline Nascimento , Silva Ranieri Moreira da , Francisco Larissa Manuelle Marciano , Santos Danyela Lays dos , Lages Itamar , Lemos Emmanuelly Correia de 
Published: November 2022

O objetivo do estudo foi descrever o processo de trabalho do profissional de Educação Física na Atenção Primária à Saúde em territórios do campo. Estudo do tipo relato de experiência sistematizado a partir das vivências dos profissionais residentes de Educação Física, inseridos na Atenção Primária à Saúde nos territórios do campo dos municípios de Garanhuns e Caruaru, cidades do Agreste Pernambucano, com populações quilombolas e assentados de territórios de reforma agrária, no período de janeiro a agosto de 2021. O processo de trabalho dos profissionais de Educação Física no campo é marcado por agentes, objetos, meios, produtos e resultados que caracterizam o trabalho na Atenção Primária, composto por ações de núcleo e outras abrangentes, além das especificidades da área. Perpassa por atividades individuais, coletivas, a partir da realidade e necessidades específicas da população do campo,contribuindo com a atenção à saúde, facilitando a coordenação e continuidade do cuidado dessa população.
Providing Data Samples for Free
Authors: Drakopoulos Kimon , Makhdoumi Ali 
Published: November 2022

We consider the problem of a seller of data who sells information to a buyer regarding an unknown (to both parties) state of the world. Traditionally, the literature explores one-round strategies for selling information because of the seller’s holdup problem: once a portion of the data set is released, the buyer’s estimate improves, and as a result, the value of the remaining data set drops. In this paper, we show that this intuition is true when the buyer’s objective is to improve the precision of the estimate. On the other hand, we establish that when the buyer’s objective is to improve downstream operational decisions (e.g., better pricing decisions in a market with unknown elasticity) and when the buyer’s initial estimate is misspecified, one-round strategies are outperformed by selling strategies that initially provide free samples. In particular, we provide conditions under which such free-sample strategies generate strictly higher revenues than static strategies and illustrate the benefit of providing data samples for free through a series of examples. Furthermore, we characterize the optimal dynamic pricing strategy within the class of strategies that provide samples over time (at a constant rate), charging a flow price until some time when the rest of the data set is released at a lump-sum amount. This paper was accepted by Itai Ashlagi, revenue management and market analytics. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4534 .
The transition of a mental health facility to a COVID-19 isolation ward and unit to deliver remote inpatient mental health care
Authors: Corrigan Mary , Curran Michelle , Kirwan Shane , Donohue Gráinne , Keogh Brian 
Published: November 2022

Throughout the COVID-19 pandemic, mental health services were confronted with significant challenges and mental health staff have not only had to provide a continued service for, often distressed, service users but have had to adapt practice and comply with the ever-changing public guidelines for containing the virus. There is a pressing need, therefore, to learn from the challenges that mental health services have faced and continue to face throughout different stages of the pandemic. While uncertainty is inevitable in pandemics, mental health nurses as a community can learn from individual experiences of adaptation. This article describes the unique and rapid transition of one Irish mental health facility to a COVID-19 isolation ward and unit for delivery of remote admission to a mental health service (home care admission). In order to capture this transitory experience, the areas discussed include preparation of the site, key challenges and the role of nursing staff, mental health service delivery, managing home care packages, the nurse management role and remote ward nursing. This discussion demonstrates how one mental health setting successfully evolved and met the challenges brought by the global pandemic through a combination of adaptability and flexibility in service delivery.
Influence of Tempering Methods on Waxy White Sorghum Kernel, Milling, and Flour Properties
Authors: Yoganandan Mohana , Buenavista Rania Marie , Bean Scott R. , Aramouni Fadi M. , Dogan Hulya , Siliveru Kaliramesh 
Published: November 2022

Highlights

Tempering moisture content and condition had a significant impact on waxy white sorghum kernel and flour properties.

Physical sorghum kernel properties after tempering varies with efficiency of moisture penetration into kernels.

Steam tempering for 15 s led to better physical kernel properties for handling, transportation, and processing.

Room temperature water tempering (18%, 24 h) yielded better flour yield and protein content.

Abstract. To optimize the yield and quality of waxy white sorghum flour, the effects of various tempering treatments on sorghum kernel physical properties, milling performance, and flour properties were evaluated. Waxy white sorghum kernels were tempered at different moisture levels and for different times using either room temperature water, hot water, or steam. Tempered sorghum kernels were milled into flour using a milling flowsheet developed for a laboratory-scale tabletop roller mill that consists of four break rolls and eight reduction rolls. The effects of these tempering methods on waxy white sorghum kernel properties, roller milling, and flour properties were investigated. Tempering moisture content and condition had a significant impact on the waxy white sorghum kernel’s physical and flour properties. Steam tempering for 15s led to desirable physical kernel properties that would positively impact handling, transportation, and processing: lower bulk (732.53 kg/m3), tapped (769.39 kg/m3), and true densities (1313.37 kg/m3); lower hardness index (65.01); higher abrasive hardness index (AHI) (23.73); higher angle of repose (23.60); and higher coefficients of static (0.35) and rolling friction (0.29). In terms of milling, room temperature water tempering at 18% w.b. moisture level for 24 h resulted in better bran-endosperm separation without compensating for important flour quality characteristics. It exhibited higher protein content (9.72%), low ash content (0.94%), high bran extraction (6.42%), and high brightness (80.67). Room temperature water tempering at 18% w.b. for 24 h is a more suitable pretreatment prior to the milling of waxy white sorghum kernels in terms of flour yield and quality. Keywords: Flour properties, Kernel properties, Roller milling, Tempering, Waxy white sorghum.