bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vonoprazan - a new drug for inhibiting gastric acid secretion
Authors: Niewęgłowski Kacper , Wilczek Natalia , Rycharski Michał , Niewęgłowska Julita 
Published: August 2022

Introduction and purpose
Vonoprazan is a potassium-competent acid blocker (P-CAB). It has the potential to be an alternative to proton pump inhibitors (PPIs) as it inhibits hydrochloric acid secretion. The mechanism of action is different than PPIs - vonoprazan reversibly inhibits gastric H+, K+-ATPase, while PPIs irreversibly. Vonoprazan is approved for use in Japan and the US. The aim of the study was to review articles on the use of vonoprazan instead of PPIs in the treatment of acid-related gastrological diseases and to present the results obtained.

A brief description of the state of knowledge
Vonoprazan is used in the treatment of acid-related gastrological diseases. The 20 mg dose is suitable for most diseases, such as treatment of ulcers during low-dose aspirin treatment, post-endoscopic submucosal dissection (post-ESD) ulcers, erosive esophagitis (EE) in gastroesophageal reflux disease (GERD), and Helicobacter pylori eradication.

Summary
Researches suggest that the drug is an alternative for PPIs and can be used instead of them. The main advantage of this drug over PPIs is that it works faster, more potent and long-lasting. Studies suggest that vonoprazan can be use to treatment of the acid-related diseases and may be a better choice than PPIs. Vonoprazan may have a particular use in the treatment of PPI-refractory GERD. In post-ESD ulcers, a significant benefit in treatment effects of vonoprazan over PPIs cannot be clearly concluded.
Analysis of the bacterial flora of periodontal pockets and evaluation of the diagnostic value and the validity of using the PET test in the detection of Sockransky’s red complex pathogens at various stages and degrees of periodontitis
Authors: Adamus Aleksandra , Cabon Julia , Mrożek Martyna , Rudzińska Iwona , Sekuła Sylwia , Wilk Anna , Wierucka-Młynarczyk Beata 
Published: August 2022

Introduction: In microbiological diagnostics, a significant role is played by the PET test based on a polymerase chain reaction developed thanks to medical engineering methods, which, by amplifying specific fragments of genetic material, enables the identification of microorganisms. As a consequence, it is possible to quantify and qualify a sample of biological material under study, which has found application in the diagnosis and treatment of periodontitis.
Aim:The following paper shows the validity of carrying out the PET test in people with clinically diagnosed chronic periodontitis who also suffer from other loads, such as smoking or systemic diseases, as well as the physiological state of pregnancy.Another goal is also to confirm the presence of Sockransky's red complex bacteria responsible for the development of periodontitis.Material and Methods:The research was carried out at the Clinic of Conservative Dentistry and Periodontal Diseases, performing an examination of 4 patients, and then after determining the deepest periodontal pockets, biological material was collected from them and sent to a bacteriological laboratory, where it was analyzed.Results:The quantitative and qualitative determination of the samples of biological material collected from the pockets of the patients showed the presence of the red complex bacteria according to Sockransky, especially the species: Treponema denticola and Porphyromonas gingivalis.Conclusions: In the studied clinical cases, the PET test confirmed the presence of bacteria responsible for periodontitis. The legitimacy of its use was also confirmed, emphasizing that it is a tool that can be used by a dentist in implementing therapeutic decisions in the treatment of periodontitis.
VLA15 - a potential Lyme disease vaccine
Authors: Czarnota Jakub , Dobrzyński Michał , Skubel Tomasz , Drozd Małgorzata , Dudek Iga , Rybak Natalia 
Published: August 2022

Introduction: Lyme disease is the most common disease transmitted by ticks. In Poland, over 20,000 cases of this disease were diagnosed in 2019. The first vaccine approved to prevent this condition was Lymerix. Currently, we do not have any preparation registered for this purpose. Data from Phase 2 trials of VLA15 show strong immunogenicity in both adults and children, with an acceptable safety and tolerability profile in both study populations
Aim: The purpose of this paper is to present the current state of the art in research into the VLA15 vaccine.
Results: Phase 3 of the VALOR study has started. Ultimately, about 6,000 participants aged 5 and older are to take part in it. The experiment is conducted in a dozen or so sites located in areas where Lyme disease is highly endemic. Participants will receive three doses of VLA15 180 µg or a placebo in saline as the first series of vaccinations, followed by one booster dose of VLA15 or placebo in 0.9% NaCl (1: 1 ratio).
Conclusion: Phase 2 studies on VLA15 showed promising results. Phase 3 of the research is ongoing.
Key words: VLA15, Lyme disease, Borrelia
Preparer Opposition and Strategic Implementation of Governmental Accounting Standards: Evidence from Public Pension Accounting Reform
Authors: Allen Abigail , Petacchi Reining C. 
Published: August 2022

Widely acknowledged as one of the most controversial standards in governmental accounting, Governmental Accounting Standards Board (GASB) Statements 67/68 radically altered both the recognition and measurement for defined benefit public pensions. The standards require the recognition of previously only disclosed unfunded pension liabilities and increase the magnitude of reported pension liabilities by requiring the partial incorporation of a market-based discount rate. Although the recognition proposal was unaltered from its initial conception to the final standards, the discount rate proposal was significantly attenuated after the initial proposal met with unanimous preparer opposition. Accordingly, we examine what incentives drive preparer lobbying positions, whether such lobbying is aligned with user interests, and how such lobbying affects ex post implementation of the final standard. Our results suggest a misalignment between preparer lobbying and a user interest perspective. In particular, although state opposition for liability-increasing proposals is positively associated with expected financial statement impact, economic constraints, and political ramifications, user lobbying exhibits the opposite relationship, suggesting that users demand greater transparency in the states most likely to eschew it. We further find that state governments consistently opposed to the market-based discount rate are more likely to maintain status quo higher discount rates that lower reported liabilities after the implementation of GASB 67/68. Examining the mechanism, we find that opposing states avoid the market-rate trigger by increasing required contributions from employees rather than by increasing government funding or implementing benefit cuts. The evidence taken together contributes to our understanding of the development and implementation of the landmark GASB 67/68 standards. This paper was accepted by Brian Bushee, accounting. Funding: The authors acknowledge financial support from Brigham Young University and Georgetown University. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4515 .
A decolonialidade em direção ao feminisno negro quilombola: uma reflexão necessária
Authors: Carvalho Francisca Edilza Barbosa de Andrade , Castilho Suely Dulce de 
Published: August 2022

Este artigo é parte do resultado dos estudos desenvolvidos pelo Grupo de Pesquisa em Educação Quilombola da Universidade Federal de Mato Grosso, com um viés voltado para a compreensão do decolonialismo como meio de o feminismo negro da mulher quilombola ressignificar a sua história na sociedade. Como lócus da pesquisa, que possui abordagem qualitativa, por meio de uma revisão bibliográfica de autoras negras que abordam o tema, adotou-se o território quilombola Vão Grande, no município de Barra do Bugres (MT). Para tanto, buscou-se responder ao seguinte questionamento: de acordo com as concepções de teóricas negras, quais indícios na sociedade contemporânea continuam reforçando as desigualdades raciais e de gênero em relação às mulheres negras quilombolas? Assim, o objetivo delineado foi o de analisar sobre os saberes e os fazeres das mulheres negras quilombolas e como essas mulheres são (re)conhecidas espacial e culturalmente de acordo com os constructos teóricos, buscando verificar se, diante do avanço da contemporaneidade, o papel da mulher negra quilombola vem sendo ressignificado. Concluiu-se que, mesmo com os avanços nos estudos e nos entendimentos que visam romper com a visão da colonização e da subalternidade, ainda que as mulheres entrevistadas no decorrer da pesquisa apresentem conquistas pessoais, como o acesso ao estudo e à formação, o discurso hegemônico colonial ainda prevalece, de forma que necessário se faz fomentar debates e políticas públicas para a sua efetiva desconstrução.
End-of-life simulation: a cross-field evaluation in an undergraduate nursing programme
Authors: Parry Maria , Jones Bridie , Churcher Clare 
Published: August 2022

Background: Death can cause a great deal of anxiety in nursing students for a variety of reasons. They are expected to provide a high level of care for patients, give the family the respect and patience they deserve and contend with the associated emotional attachments. This raised the question in today's educational world—can the use of technology and simulation aid students in preparing for an end-of-life scenario as part of an undergraduate nursing programme? Aim: To explore the efficacy of the use of simulations in end-of-life care. Method: A small study focusing upon the evaluation of an end-of-life simulated scenario for undergraduate second year cross-field Bachelor of Nursing students in a university setting. The simulated scenario consisted of a young patient who was dying and her mother. This project used a mixed approach to address varied students' learning styles and combined the need for visualisation and more structured base-sessions on the topic of death and end-of-life care. One student from the cohort group was randomly assigned as the nurse in charge, while other students were allocated to a scenario (out of a potential four) and provided care in real time. Subsequently, the impact of the scenario was assessed and students were immediately debriefed. Students' response to the scenario was important and needed to be considered, as it directly influenced the debriefing. There were some significant differences between how the students approached the scenario and their reaction to it. Results: Of the students who took part in the end-of-life simulated scenario, the majority strongly agreed that the simulation increased their clinical reasoning and learning. Conclusion: The end-of-life scenario was deemed beneficial, despite the emotional impact on the learners involved.
On the same page? A qualitative study protocol on collaboration in a multi-laboratory preclinical study
Authors: Evans Jenna M. , Peever Alexander , Grudniewicz Agnes , McDonald Braedon , Mendelson Asher A. , Lalu Manoj M. 
Published: August 2022

Introduction
Medical advancements are slow to reach the patient bedside due to issues with knowledge translation from preclinical studies. Multi-laboratory preclinical studies are a promising strategy for addressing the methodological deficiencies that weaken the translational impact of single laboratory findings. However, multi-laboratory preclinical studies are rare and difficult, requiring strong collaboration to plan and execute a shared protocol. In multiteam systems such as these, collaboration is enhanced when members have cohesive ways of thinking about their goals and how to achieve them–that is, when they have “shared mental models”. In this research project, we will examine how members of Canada’s first multi-laboratory preclinical study build shared mental models and collaborate in the execution of their study.

Methods
Six independent labs in Canada will conduct a preclinical study using a common protocol. To investigate mental models and collaboration in this multiteam system we will conduct a longitudinal qualitative study involving interviews at four time points, team observation, and document analysis. We will analyze interview transcripts using deductive coding to produce a matrix analysis of mental model content over time and inductive coding to produce a thematic analysis of members’ experiences of collaboration over time. We will also triangulate data sources to “tell the story” of teamwork, capturing events and contextual information that explain changes in mental models and collaboration over time.

Discussion
This study will be one of the most comprehensive longitudinal analyses of a real-world multiteam system, and the first within a preclinical laboratory setting. The results will contribute to our understanding of collaboration in multiteam systems, an organizational form increasingly used to tackle complex scientific and social problems. The results will also inform the implementation of future multi-laboratory preclinical studies, enhancing the likelihood of effective collaboration and improved ‘bench to bedside’ translation.
CUNHA, Luiz Antônio. O ensino profissional na irradiação do industrialismo. 2. ed. São Paulo: Editora UNESP; Brasília, DF: FLACSO, 2005. 270 p.
Authors: Romanini de Oliveira Renata Cristiane , Pedrosa José Geraldo 
Published: August 2022

CUNHA, Luiz Antônio. O ensino profissional na irradiação do industrialismo. 2. ed. São Paulo: Editora UNESP; Brasília, DF: FLACSO, 2005. 270 p.
Apresentado originalmente em 1999 para o Projeto Replanfor, da Secretaria de Formação e Desenvolvimento Profissional, do Ministério do Trabalho, e incorporado como parte dos trabalhos sobre o tema que o autor vem desenvolvendo desde 1972, quando da defesa de sua dissertação de mestrado, o livro é uma relevante contribuição para os estudos sobre a história da educação profissional no Brasil. Constitui o terceiro volume da trilogia publicada pelo autor sobre o ensino técnico-profissional, antecedido das seguintes obras: O ensino de ofícios artesanais e manufatureiros no Brasil escravocrata (2000) e O ensino de ofícios nos primórdios da industrialização (2000).
O livro retrata o desenvolvimento da educação profissional brasileira, no período que vai do Governo Provisório pós-1930 até ao fim do século XX. Numa continuidade de sua extensa produção historiográfico[1]educacional e partindo de um posicionamento teórico-metodológico crítico, Cunha consegue captar as vicissitudes do movimento histórico do trabalho e da educação para o trabalho no Brasil no período correspondente, embora muitas vezes se referindo ao Brasil acabe generalizando e dando ênfase aos grandes centros como São Paulo e Rio de Janeiro.
Cunha parte do ensino orientado pela força de trabalho industrial e manufatureira para abordar o ensino profissional, demonstrando que a constituição deste “grande aparato educacional” não é um processo linear e homogêneo. O autor busca reconstruir a lógica interna às políticas educacionais, descrevendo com exatidão a legislação correspondente, explicada por suas implicações ideológicas e disputas hegemônicas que se desenvolveram no campo educacional. Além das mudanças ocorridas no processo produtivo, o autor também descreve como os protagonistas envolvidos com o ensino profissional as encararam. Este livro culmina com a apresentação de um campo educacional marcado por conflitos, sobretudo no que diz respeito ao Serviço Nacional de Aprendizagem Industrial (SENAI), instituição que o autor dá atenção especial. [...]
Data de registro:13/02/2012
Data de aceite:03/10/2012
Myocardial Scintigraphy in Diagnosing Cardiac Transthyretin Amyloidosis
Authors: Petrovic Marija , Lopez Persio D. , Eng Calvin , Rashid Mahjabeen 
Published: August 2022

Myocardial scintigraphy with technetium-99m pyrophosphate is a minimally invasive technique that can distinguish between transthyretin amyloidosis (ATTR) and light-chain amyloidosis. We present a case in which it helped determine the amyloidosis type in a 74-year-old man with cardiac amyloidosis and multiple previous admissions for acute decompensated heart failure.
The patient presented with increasing abdominal girth and bilateral lower extremity edema. His medical history also included atrial fibrillation, liver cirrhosis, hypertension, stage 3 chronic kidney disease, and peripheral vascular disease. We prescribed guideline-directed medical therapy for his acute decompensated heart failure with cardiorenal syndrome and his decompensated cirrhosis.
Two years previously, a presumptive diagnosis of ATTR cardiomyopathy had been made on the basis of the patient's age, predominantly cardiac involvement, an unremarkable serum protein electrophoresis result, and an abnormal free κ/λ light-chain ratio of 2.24. Over the next year, the patient's clinical condition had worsened with the development of liver cirrhosis and peripheral neuropathy, and his free κ/λ light-chain ratio had become even more abnormal. At the current presentation, a technetium-99m pyrophosphate nuclear scintigram revealed a free κ/λ light-chain ratio of 1.52. This, combined with the patient's age and slow progression of primarily cardiac disease, supported the diagnosis of ATTR, and we prescribed tafamadis.
This case suggests that technetium-99m pyrophosphate scintigraphy is valuable in definitively diagnosing ATTR cardiomyopathy and selecting patients who may benefit from disease-modifying therapy.
Alendronato de sódio e vitamina D na osteoporose pós-menopausa
Authors: Júnior José Reginaldo Alves de Queiroz , Pereira Jarson Pedro da Costa , Pires Leonardo Lucas , Maia Carina Scanoni 
Published: August 2022

Objetivo: avaliar a eficácia da utilização da terapia combinada de alendronato de sódio e vitamina D no metabolismo ósseo de mulheres em tratamento de osteoporose pós-menopausa.Métodos: trata-se de uma revisão sistemática, a qual foram pesquisados ensaios clínicos randomizados (ECR) indexados nas bases de dados BVS, ISI Web of Science, PubMed, SciELO, ScienceDirect e Scopus que comparavam a associação de alendronato sódico e vitamina D com a monoterapia de alendronato de sódio. Resultados: um total de seis ECR contemplou os critérios para serem inclusos nesse estudo, compreendendo um total de 4164 participantes e seus respectivos dados. Os estudos avaliaram diferentes domínios do metabolismo ósseo, como níveis séricos de vitamina D, paratormônio, densidade mineral óssea e marcadores de turnover ósseo. A terapia combinada produziu melhora significativa nos marcadores metabólicos ósseos. Conclusão: a terapia combinada de alendronato de sódio com vitamina D promove melhora no metabolismo ósseo de mulheres com osteoporose pós-menopausa.
Indicadores de sustentabilidad ecológica para diferentes secuencias agrícolas en la región pampeana de Argentina
Authors: Golik Silvina , Chamorro Adriana M. , Bezus Rodolfo , Pellegrini Andrea , Voisin Axel 
Published: August 2022

Introducción. La intensificación de la agricultura con la soja (Glycine max L.) como principal componente del sistema de producción provoca perjuicios importantes en el suelo de Argentina y de muchos otros lugares del mundo. Objetivo. Evaluar la sustentabilidad ecológica de cuatro secuencias agrícolas, bajo distintos manejos de sus barbechos. Materiales y métodos. El ensayo se llevó a cabo en la Estación Experimental J. Hirschhorn de la Facultad de Ciencias Agrarias y Forestales, Universidad Nacional de La Plata (34° 52´ LS, 57° 58´ LO), Buenos Aires, Argentina, donde desde el año 2011 se ha trabajado con cuatro secuencias de cultivos y, a partir del año 2015, con cuatro manejos distintos de sus barbechos (testigo, compost, cultivo de cobertura sin fertilizante y cultivo de cobertura más fertilizante). Para la evaluación de la sustentabilidad se usaron cinco indicadores: balance de N, P, S y de carbono, además, eficiencia de uso del agua. Asimismo, se calculó el índice de sustentabilidad. Resultados. La secuencia cebada (Hordeum vulgare L.) / soja (Glicine max L.) 2da - maíz (Zea mays L.) - soja-trigo (Triticum aestivum L.) fue la de mayor sustentabilidad bajo tres de los cuatro manejos. La secuencia trigo / soja 2da – soja – soja – trigo fue la de menor sustentabilidad para todos los manejos realizados. Conclusión. Las secuencias analizadas presentaron diferencias en la sustentabilidad ecológica, lo que indica la importancia de la elección de sus componentes en la búsqueda de mejorar la sustentabilidad de los agroecosistemas. La utilización de cultivos de cobertura en los barbechos mejoró la sustentabilidad, cuando se asoció a un mayor uso de fertilizantes y cuando no fue así. El uso de compost tuvo un efecto inmediato menor, ya que solo en la secuencia con mayor frecuencia de soja produjo mejoras en la sustentabilidad.
Castellano Rioplatense in Australia
Authors: Natolo Stephanie 
Published: August 2022

In an era marked by globalisation and migration, heritage languages and their use in particular societies is gaining interest. Yet, research into one of the world’s largest heritage languages, Spanish, has primarily focussed on the United States of America. This article examines an under-researched topic of the Spanish-speaking community in Australia. This heterogenous community is far more recent and has received far less scholarly recognition than that of its closely researched North American counterpart. Moreover, considering the complexity of language usage, heritage language research has concentrated on standardised use rather than on regional dialects. This directly influences the strategic significance of regional dialects as Latin American Australians are framed as a homogenous community to the broader Anglophone public. This article adds to the current body of research from a unique Australian perspective. Survey and interview data from 100 members of the Argentinian community explores their reasons and use of Castellano Rioplatense. It argues that Castellano Rioplatense is perceived to accrue status and is a means where Argentineans maintain a distinct linguistic and cultural differentiation within the broader Latin American community.
Escritura en artes: creencias, tensiones y retos
Authors: Colmenares Sol , Vergara Luján Omaira , Salamanca Solis Martha Lucía 
Published: August 2022

En este artículo exploramos el vínculo con la escritura de un grupo de profesores adscritos a programas de licenciaturas en artes. En datos recolectados a través de entrevistas a profundidad, analizamos su autopercepción como escritores, las imágenes y funciones que atribuyen a la escritura universitaria y las creencias que tienen sobre su enseñanza y aprendizaje. Aunque en los resultados sobresale una apropiación fuerte y positiva de la escritura —entendida como práctica ligada al quehacer docente, con funciones de carácter epistemológico, profesional y personal— esto no se traduce en actitudes favorables hacia su enseñanza. Concluimos que la didáctica de la escritura en las licenciaturas en artes necesita de una intervención urgente, en el marco de una política institucional, que asegure su presencia a lo largo de la formación y que se formule teniendo en cuenta el lenguaje de las artes y sus prácticas, que se reflejan en modos particulares de escribir.