bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated gut microbiota and serum metabolomics reveal the protective effect of oleanolic acid on liver and kidney‐injured rats induced by Euphorbia pekinensis
Authors: Wang Kuilong , Xu Xiaofen , Shan Qiyuan , Ding Rui , Lyu Qiang , Huang Lichuang , Chen Xinyi , Han Xin , Yang Qiao , Sang Xianan , Peng Mengyun , Hao Min , Cao Gang 
Published: November 2022

AbstractEuphorbia pekinensis (EP) is a commonly used Chinese medicine treating edema with potential hepatorenal toxicity. However, its toxic mechanism and prevention are remained to be explored. Oleanolic acid (OA) is a triterpene acid with potential hepatorenal protective activities. We investigated the protective effect and potential mechanism of OA on EP‐induced hepatorenal toxicity. In this study, rats were given total diterpenes from EP (TDEP, 16 mg/kg) combined with OA (10, 20, 40 mg/kg) by gavage for 4 weeks. The results showed that TDEP administration could lead to a 3–4‐fold increasement in hepatorenal biochemical parameters with histopathological injuries, while OA treatment could ameliorate them in a dose‐dependent manner. At microbial and metabolic levels, intestinal flora and host metabolism were perturbed after TDEP administration. The disturbance of bile acid metabolism was the most significant metabolic pathway, with secondary bile acids increasing while conjugated bile acids decreased. OA treatment can improve the disorder of intestinal flora and metabolic bile acid spectrum. Further correlation analysis screened out that Escherichia‐Shigella, Phascolarctobacterium, Acetatifactor, and Akkermansia were closely related to the bile acid metabolic disorder. In conclusion, oleanolic acid could prevent hepatorenal toxicity induced by EP by regulating bile acids metabolic disorder via intestinal flora improvement.
Adverse adult experiences and health outcomes: Racial and ethnic differences in a low‐income sample
Authors: Mersky Joshua , Plummer Lee ChienTi , Janczewski Colleen 
Published: November 2022

AbstractExtending research on adverse childhood experiences (ACEs), this study aimed to investigate whether the prevalence of and outcomes associated with adverse adult experiences vary among racial and ethnic subgroups. Survey data were collected from 1566 low‐income women in Wisconsin using the Adult Experiences Survey (AES). Ten major adult adversities were assessed, including items that reference an intimate partner or household member (e.g., physical or emotional abuse, substance use) along with other social and economic stressors such as homelessness and discrimination. Adverse adult experiences were highly prevalent overall, but even more so among non‐Hispanic Whites than their Black and Hispanic counterparts. The results reinforce prior research on ACEs in low‐income populations. Lending further credence to these findings, tests of measurement invariance indicated that the AES demonstrated acceptable configural and scalar invariance across racial and ethnic groups. As expected, greater exposure to adult adversity was significantly related to poorer physical and mental health. These associations manifested cross‐sectionally and longitudinally for observed and latent measures of adult adversity—even after controlling for ACEs. Associations between adult adversity and health were not moderated by race/ethnicity. In sum, adverse adult experiences were unequally distributed across racial/ethnic groups, but the consequences associated with adversity appeared to be evenly dispersed.
Cell‐Mimic Directional Cargo Transportation in a Visible‐Light‐Activated Colloidal Motor/Lipid Tube System
Authors: Ghellab Salah Eddine , Zhang Xinyuan , Yang Yicheng , Wang Shuo , Basharat Majid , Zhou Xuemao , Lei Lijie , Zhou Ye , Wang Yufeng , Fang Hui , Gao Yongxiang 
Published: November 2022

AbstractActive tether and transportation of cargoes on cytoskeletal highway enabled by molecular motors is key for accurate delivery of vesicles and organelles in the complex intracellular environment. Here, a hybrid system composed of colloidal motors and self‐assembled lipid tubes is designed to mimic the subcellular traffic system in living cells. The colloidal motors, composed of gold‐coated hematite, display light‐activated self‐propulsion tunable by the light intensity and the concentration of hydrogen peroxide fuel. Importantly, the motors show light‐switchable binding with lipid cargoes and attachment to the lipid tubes, whereby the latter act as the motor highways. Upon assembly, the colloidal motor/lipid tube system demonstrates directional delivery of lipid vesicles, emulating intracellular transportation. The assembly and function of the hybrid system are rationalized by a cooperative action of light‐triggered electrophoretic and hydrodynamic effects, supported by finite element analysis. A synthetic analog of the biological protein motor/cytoskeletal filament system is realized for the manipulation and delivery of different matter at the microscale, which is expected to be a promising platform for various applications in materials science, nanotechnology, microfluidics, and synthetic biology.
Copper‐Based Metal‐Organic Framework Induces NO Generation for Synergistic Tumor Therapy and Antimetastasis Activity
Authors: Ren Debao , Cheng Yibin , Xu Wenxuan , Qin Wenjun , Hao Tonghui , Wang Fei , Hu Yun , Ma Lixin , Zhang Cheng 
Published: November 2022

AbstractThe interaction between platelets and circulating tumor cells (CTCs) contributes to distal tumor metastasis by protecting CTCs from immunological assault and shear stress, which can be disrupted by nitric oxide (NO) through inhibiting platelet‐mediated adhesion. To eradicate primitive tumors and inhibit CTC‐based pulmonary metastasis, a novel biomimetic nanomedicine (mCuMNO) is designed by encapsulating Cu+‐responsive S‐nitrosoglutathione as a NO donor into a copper‐based metal‐organic framework (CuM). This work discovers that mCuMNO can target tumor regions and deplete local glutathione (GSH) to reduce Cu2+ to Cu+, followed by triggering NO release and hydroxyl radicals (·OH) production, thereby interrupting platelet/CTC interplay and contributing to chemodynamic therapy. Detailed studies demonstrate that mCuMNO exhibits high efficiency and safety in tumor therapy and antimetastasis activity, sheding new light on the development of CuM‐based tumor synthetic therapy.
The influence of fiber on salt frost resistance of hydraulic face slab concrete
Authors: Wang Ruijun , Cao Zhiliang , Li Yang , Shi Qi 
Published: November 2022

AbstractAs an important antiseepage structure of concrete face rockfill dam, the durability of concrete face slab is very important for the long‐term safe operation of the dam. Polypropylene fiber (PPF) and polyacrylonitrile fiber (PANF) are used as research objects to study the salt frost resistance of dual fiber Face slab concrete. The corrosion resistance of PPF and PANF concrete under different fiber volume was compared. The mass loss, residual compressive strength, relative dynamic modulus of elasticity and microstructure were evaluated in salt freezing environment. The results show that adding PPF and PANF to concrete can effectively improve the frost resistance of concrete, and the performance law is similar under the coupling failure of chloride and freeze–thaw cycles. Under the same volume, the effect of PPF concrete is more significant than PPF concrete, and the effect of adding two kinds of fibers at the same time is better than adding one fiber alone. Within the evaluation range, choosing 0.5% PPF and 0.5% PPF as additives is the best choice to improve the salt frost resistance. The results of scanning electron microscopy microstructure analysis of corrosion products are consistent with that of macro property analysis.
Botulinum toxin antibody titres: measurement, interpretation, and practical recommendations
Authors: Dressler Dirk , Rothwell John C. , Bhatia Kailash , Kopp Bruno , Bigalke Hans , Adib Saberi Fereshte 
Published: November 2022

AbstractBotulinum toxin (BT) therapy may be blocked by antibodies (BT-AB) resulting in BT-AB induced therapy failure (ABF). BT-AB may be detected by the mouse lethality assay (MLA), the mouse diaphragm assay (MDA) and the sternocleidomastoid test (SCMT). For the first time, we wanted to compare all three BT-AB tests and correlate them to subjective complaint of complete or partial secondary therapy failure in 37 patients with cervical dystonia (25 females, 12 males, age 51.2 ± 11.4 years, disease duration 12.4 ± 6.3 years). Complaint of therapy failure was not correlated with any of the BT-AB tests. MDA and MLA are closely correlated, indicating that the MDA might replace the MLA as the current gold standard for BT-AB measurement. The SCMT is closely correlated with MDA and MLA confirming that BT-AB titres and BT's paretic effect are in a functional balance: low BT-AB titres are reducing BT's paretic effect only marginally, whereas high BT-AB titres may completely block it. When therapy failure is classified as secondary and permanent, BT-AB evaluation is recommended and any BT-AB test may be applied. For MDA > 10 mU/ml, MLA > 3 and SCMT < 25%, ABF is highly likely. MDA < 0.6 mU/ml are therapeutically irrelevant. They are neither correlated with pathologic MLA nor with pathologic SCMT. They should not be the basis for treatment decisions, such as switching dystonia therapy to deep brain stimulation. All other results are intermediate results. Their interactions with therapy efficacy is unpredictable. In these cases, BT-AB tests should be repeated or one or two additional test methods should be applied.
Immunohistochemical expression of estrogen receptor alpha in the maxillary sinus, pulp, and periodontal ligament of adjacent teeth in late pregnancy in rats
Authors: Hassan Gihan S. , Helal Mai B. , Ibrahim H. F. 
Published: November 2022

AbstractThis study aimed to assess the histological changes in the maxillary sinus and its adjacent dental tissues as pulp and periodontal ligament during pregnancy and investigate the role of estrogen hormone in these changes through the detection of estrogen receptors in these tissues. Sixteen adult female rats were used and were allocated into two groups: control non-pregnant (n = 8) and pregnant (n = 8). They were sacrificed and their heads were prepared for histological and immunohistochemical examination for estrogen receptor alpha. Our results revealed that pregnant rats revealed inflammatory changes in the sinus as thick epithelial lining, loss of cilia, swollen goblet cells, intraepithelial and interstitial edema. The lamina propria demonstrated considerable infiltration of inflammatory cells, glandular hyperplasia with vacuolar degeneration, and vascular congestion. Periodontal ligament and pulp revealed hyperemia and vascular congestion. Immunohistochemical examination of estrogen receptor alpha in the maxillary sinus and adjacent dental tissues (Periodontal ligament and pulp) in pregnant rats revealed a significant increase in its expression in all examined tissues. In conclusion, there was an increase in expression of ERα in the sinus mucosa and dental tissues during pregnancy together with slight inflammatory changes in these tissues. Hence, dentists should be aware of the effect of these changes on the pregnant women avoiding teeth extraction due to misdiagnosis of dental, periodontal or sinus pain after exclusion of true pathologies.
Emotion contagion in agent-based simulations of crowds: a systematic review
Authors: van Haeringen E. S. , Gerritsen C. , Hindriks K. V. 
Published: November 2022

AbstractEmotions are known to spread among people, a process known as emotion contagion. Both positive and negative emotions are believed to be contagious, but the mass spread of negative emotions has attracted the most attention due to its danger to society. The use of agent-based techniques to simulate emotion contagion in crowds has grown over the last decade and a range of contagion mechanisms and applications have been considered. With this review we aim to give a comprehensive overview of agent-based methods to implement emotion contagion in crowd simulations. We took a systematic approach and collected studies from Web of Science, Scopus, IEEE and ACM that propose agent-based models that include a process of emotion contagion in crowds. We classify the models in three categories based on the mechanism of emotion contagion and analyse the contagion mechanism, application and findings of the studies. Additionally, a broad overview is given of other agent characteristics that are commonly considered in the models. We conclude that there are fundamental theoretical differences among the mechanisms of emotion contagion that reflect a difference in view on the contagion process and its application, although findings from comparative studies are inconclusive. Further, while large theoretical progress has been made in recent years, empirical evaluation of the proposed models is lagging behind due to the complexity of reliably measuring emotions and context in large groups. We make several suggestions on a way forward regarding validation to eventually justify the application of models of emotion contagion in society.
Wood lignocellulosic stabilizers: effect of their characteristics on stability and rheological properties of emulsions
Authors: Ho Thao Minh , Abik Felix , Hietala Sami , Isaza Ferro Estefania , Pitkänen Leena , Juhl Dennis W. , Vosegaard Thomas , Kilpeläinen Petri O. , Mikkonen Kirsi S. 
Published: November 2022

AbstractLignocellulosic materials from the forest industry have shown potential to be used as sustainable hydrocolloids to stabilize emulsions for many applications in life science and chemical industries. However, the effect of wood species and recovery method on the product’s properties and ability to stabilize emulsions of isolated lignocellulosic compounds is not well understood. Hemicelluloses, abundant lignocellulosic side stream, exhibit differences in their water solubility, anionic character, lignin content, and degree of acetylation. Here, we explored stability and rheological properties of model emulsions (5% hexadecane and 1% stabilizer, w/w) stabilized by different grades of sprucewood galactoglucomannan (GGM) and birchwood glucuronoxylan (GX) hemicelluloses. The results were compared to known soluble, insoluble, charged, and non-charged cellulosic stabilizers, namely methyl cellulose (MC), carboxymethyl cellulose (CMC), anionic- and nonionic-cellulose nanocrystals (aCNC and dCNC). The results showed that GX emulsions were highly stable compared to GGM emulsions, and that deacetylation and lignin removal markedly reduced emulsion stability of GGM. Carboxymethylation to increase anionic characters enhanced the emulsion stabilization capacity of GGM, but not that of GX. Investigating flow behaviors of emulsions indicated that hemicelluloses primarily stabilize emulsions by adsorption of insoluble particles, as their flow behaviors were similar to those of cellulose nanocrystals rather than those of soluble celluloses. Understanding the impact of the variations in composition and properties of hemicellulose stabilizers to stabilize emulsions allows tailoring of their recovery processes to obtain desirable hydrocolloids for different applications.
Harry Potter and the Social Construct. Does Gender-Swap Fanfiction Show Us That We Need to Re-consider Gender Within Children’s Literature?
Authors: Oulton Harry 
Published: November 2022

AbstractIn this paper I look at how gender is performed in fanfiction, specifically in gender-swap stories within the Harry Potter fandom. Fanfiction is not constrained by any editorial oversight, and there are no financial considerations attached to either reading or writing it, two facts which make it a unique and essential part of the discourse surrounding children’s literature. Anyone can write and read it, and there are very few narrative constraints, both of which make the characters and the worlds open to almost infinite types of adaptation. Rather than being closed off within a printed text, the characters take on an elasticity which allows them to exist in worlds, relationships and stories outside their source material. This narrative freedom means fan fictions act not just as textual adaptations, but also social commentaries, narrative sites which are plastic enough to allow writers to project themselves and their opinions onto pre-existing and familiar characters. This elasticity and textual fluidity lends itself very well to a study of contemporary performances of gender, which in turn reveals how the offline publishing market’s adherence to a patriarchal hegemony continues to produce a gender imbalance in terms of both subject and author privilege, something which doesn’t adequately reflect either the desires or the reading habits of contemporary children and young adults.
A Dilemma for the Russo–Williamson Thesis
Authors: Wilde Michael 
Published: November 2022

AbstractThe Russo–Williamson thesis maintains that establishing a causal claim in medicine normally requires establishing both a correlation and a mechanism. In this paper, I present a dilemma for defenders of this thesis: a strong version of the thesis requires denying a plausible counterexample, but as the thesis is weakened, its defenders must give up their favoured account of the explanatory role of causal claims in medicine. I appeal to some recent work in epistemology on infallibilism to propose a way out of this dilemma, where this way out requires neither denying the plausible counterexample nor giving up the favoured account. I think this shows that even apparently abstract debates in epistemology can provide resources that may help to resolve debates in the philosophy of science and medicine.
Genetic diversity of pea (Pisum sativum L.) genotypes differing in leaf type using SNP markers
Authors: Tran Chi Thanh , Beissinger Timothy M. , Becker Heiko C. , Horneburg Bernd 
Published: November 2022

AbstractA collection of 46 pea (Pisum sativum L.) accessions, mostly from Europe, were analysed for genetic diversity using the GenoPea 13.2 K SNP Array chip. Of these accessions were 24 nomal-leaved and 22 semi-leafless. Principal components analysis (PCA) separated the peas into two groups characterized by the two different leaf types, although some genotypes were exceptions and appeared in the opposite group. Cluster analysis confirmed the two groups. A dendrogram showed larger genetic distances between genotypes in the normal-leafed group compared to semi-leafless genotypes. Both PCA and cluster analysis show that the two leave types are genetically divergent. So normal-leaved peas are an interesting genetic resource, even if the breeding goal is to develop semi-leafless varieties.
Sutureless scleral fixation Carlevale IOL: a review on the novel designed lens
Authors: Carlà Matteo Mario , Boselli Francesco , Giannuzzi Federico , Caporossi Tomaso , Gambini Gloria , Mosca Luigi , Savastano Alfonso , Rizzo Stanislao 
Published: November 2022

AbstractBackground: Complicated cataract surgery is the main cause of secondary lens implantation surgery. Several approaches have been introduced to face those circumstances. As it concerns scleral-fixated IOLs for the posterior chamber, many types of IOL can be implanted. The aim of article is to review the single piece sutureless scleral fixation Carlevale lens; Methods: Narrative review; Results: Several works described as safe the IOL implantation utilizing the handshake approach, without tactile manipulation, which allows for self-centration and lens firm fixation in uncomplicated surgery. This allows to reduce high order aberration such as astigmatism and coma, with a very good postoperative BCVA Conclusions: Carlevale lens is one of the best option to manage insufficient capsular support.
Stress, Eating Behavior and Adverse Health in Parents of Young Children with Autism Spectrum Disorder
Authors: van der Lubbe Anna , Swaab Hanna , Vermeiren Robert R. J. M. , Ester Wietske A. 
Published: November 2022

AbstractMothers of children with Autism Spectrum Disorder (ASD) often experience chronic stress and are at risk for adverse health. However, little is known about fathers, especially when their child is in early childhood. Parenting stress, eating behavior and physical health was evaluated in mothers (n = 48) and fathers (n = 43) of young children (3–7 years) with ASD by questionnaires and physical measurements. Mother’s prevalence rates of obesity (39.1%), abdominal obesity (59.6%) and metabolic syndrome (21.6%) were higher than the norm. In fathers, the prevalence rate of clinical parenting stress (33%) was higher than the norm. Parenting stress was positively related to disinhibited eating in mothers, not in fathers. It is crucial to monitor stress and health of parents of children with ASD.
Therapeutic Hypothermia Combined with Hydrogen Sulfide Treatment Attenuated Early Blood–Brain Barrier Disruption and Brain Edema Induced by Cardiac Arrest and Resuscitation in Rat Model
Authors: Cai Shenquan , Li Qian , Fan Jingjing , Zhong Hao , Cao Liangbin , Duan Manlin 
Published: November 2022

AbstractBrain injury remains a major problem in patients suffering cardiac arrest (CA). Disruption of the blood–brain barrier (BBB) is an important factor leading to brain injury. Therapeutic hypothermia is widely accepted to limit neurological impairment. However, the efficacy is incomplete. Hydrogen sulfide (H2S), a signaling gas molecule, has protective effects after cerebral ischemia reperfusion injury. This study showed that combination of hypothermia and H2S after resuscitation was more beneficial for attenuated BBB disruption and brain edema than that of hypothermia or H2S treatment alone. CA was induced by ventricular fibrillation for 4 min. Hypothermia was performed by applying alcohol and ice bags to the body surface under anesthesia. We used sodium hydrosulphide (NaHS) as the H2S donor. We found that global brain ischemia induced by CA and cardiopulmonary resuscitation (CPR) resulted in brain edema and BBB disruption; Hypothermia or H2S treatment diminished brain edema, decreased the permeability and preserved the structure of BBB during the early period of CA and resuscitation, and more importantly, improved the neurologic function, increased the 7-day survival rate after resuscitation; the combination of hypothermia and H2S treatment was more beneficial than that of hypothermia or H2S treatment alone. The beneficial effects were associated with the inhibition of matrix metalloproteinase-9 expression, attenuated the degradation of the tight junction protein occludin, and subsequently protected the structure of BBB. These findings suggest that combined use of therapeutic hypothermia and hydrogen sulfide treatment during resuscitation of CA patients could be a potential strategy to improve clinical outcomes and survival rate.
Partisan Stability During Turbulent Times: Evidence from Three American Panel Surveys
Authors: Green Donald P. , Platzman Paul 
Published: November 2022

AbstractThe past decade has witnessed profound changes in the tenor of American party politics. These changes, in tandem with growing affective polarization and residential segregation by party, raise the question of whether party identification is itself changing. Using three multi-wave panel surveys that stretch from the first Obama Administration through the Trump Administration, this paper takes a fresh look at the stability of party identification, using several different statistical approaches to differentiate true partisan change from response error. Perhaps surprisingly, the pace of partisan change observed between 2011 and 2020 is quite similar to the apparent rates of change in panel surveys dating back to the 1950s. Few respondents experience appreciable change in party identification in the short run, but the pace at which partisanship changes implies that substantial changes are relatively common over a voter’s lifespan.