bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining Pre-operative Diffusion Tensor Images and Intraoperative Magnetic Resonance Images in the Navigation Is Useful for Detecting White Matter Tracts During Glioma Surgery
Authors: Tamura Manabu , Kurihara Hiroyuki , Saito Taiichi , Nitta Masayuki , Maruyama Takashi , Tsuzuki Shunsuke , Fukui Atsushi , Koriyama Shunichi , Kawamata Takakazu , Muragaki Yoshihiro 
Published: January 2022

PurposeWe developed a navigation system that superimposes the fractional anisotropy (FA) color map of pre-operative diffusion tensor imaging (DTI) and intraoperative magnetic resonance imaging (MRI). The current study aimed to investigate the usefulness of this system for neurophysiological monitoring and examination under awake craniotomy during tumor removal.MethodA total of 10 glioma patients (4 patients with right-side tumors; 5 men and 5 women; average age, 34 years) were evaluated. Among them, the tumor was localized to the frontal lobe, insular cortex, and parietal lobe in 8, 1, and 1 patient, respectively. There were 3 patients who underwent surgery on general anesthesia, while 7 patients underwent awake craniotomy. The index of DTI anisotropy taken pre-operatively (magnetic field: 3 tesla, 6 motion probing gradient directions) was analyzed as a color map (FA color map) and concurrently co-registered in the intraoperative MRI within the navigation. In addition to localization of the bipolar coagulator and the cortical stimulator for brain mapping on intraoperative MRI, the pre-operative FA color map was also concurrently integrated and displayed on the navigation monitor. This white matter nerve functional information was confirmed directly by using neurological examination and referring to the electrophysiological monitoring.ResultsIntraoperative MRI, integrated pre-operative FA color map, and microscopic surgical view were displayed on one screen in all 10 patients, and white matter fibers including the pyramidal tract were displayed as a reference in blue. Regarding motor function, motor-evoked potential was monitored as appropriate in all cases, and removal was possible while directly confirming motor symptoms under awake craniotomy. Furthermore, the white matter fibers including the superior longitudinal fasciculus were displayed in green. Importantly, it was useful not only to localize the resection site, but to identify language-related, eye movement-related, and motor fibers at the electrical stimulation site. All motor and/or language white matter tracts were identified and visualized with the co-registration and then with an acceptable post-operative neurological outcome.ConclusionCo-registering an intraoperative MR images and a pre-operative FA color map is a practical and useful method to predict the localization of critical white matter nerve functions intraoperatively in glioma surgery.
Radiological Knosp, Revised-Knosp, and Hardy–Wilson Classifications for the Prediction of Surgical Outcomes in the Endoscopic Endonasal Surgery of Pituitary Adenomas: Study of 228 Cases
Authors: Araujo-Castro Marta , Acitores Cancela Alberto , Vior Carlos , Pascual-Corrales Eider , Rodríguez Berrocal Víctor 
Published: January 2022

PurposeTo evaluate which radiological classification, Knosp, revised-Knosp, or Hardy–Wilson classification, is better for the prediction of surgical outcomes in the endoscopic endonasal transsphenoidal (EET) surgery of pituitary adenomas (PAs).MethodsThis is a retrospective study of patients with PAs who underwent EET PA resection for the first time between January 2009 and December 2020. Radiological cavernous sinus invasiveness was defined as a Knosp or revised-Knosp grade &gt;2 or a grade E in the Hardy–Wilson classification.ResultsA total of 228 patients with PAs were included. Cavernous sinus invasion was evident in 35.1% and suprasellar extension was evident in 74.6%. Overall, surgical cure was achieved in 64.3% of patients. Surgical cure was lower in invasive PAs than in non-invasive PAs (28.8% vs. 83.1%, p &lt; 0.0001), and the risk of major complications was higher (13.8% vs. 3.4%, p = 0.003). The rate of surgical cure decreased as the grade of Knosp increased (p &lt; 0.001), whereas the risk of complications increased (p &lt; 0.001). Patients with Knosp 3B PAs tended to achieve surgical cure less commonly than Knosp 3A PAs (30.0% vs. 56.0%, p = 0.164). Similar results were observed based on the invasion and extension of Hardy–Wilson classification (stage A–C 83.1% vs. E 28.8% p &lt; 0.0001, grade 0–II 81.1% vs. III–IV 59.7% p = 0.008). The Knosp classification offered the greatest diagnostic accuracy for the prediction of surgical cure (AUC 0.820), whereas the invasion Hardy–Wilson classification lacked utility for this purpose (AUC 0.654).ConclusionThe Knosp classifications offer a good orientation for the estimation of surgical cure and the risk of complications in patients with PAs submitted to EET surgery. However, the invasion Hardy–Wilson scale lacks utility for this purpose.
Effect of Sophocarpine on the Pharmacokinetics of Umbralisib in Rat Plasma Using a Novel UPLC-MS/MS Method
Authors: Weng Qinghua , Lan Xia , Wang Yingjie , Fan Chen , Xu Ren-ai , Zhang Pengzhao 
Published: January 2022

Umbralisib is a dual inhibitor of phosphatidylinositol 3-kinase delta (PI3Kδ) and casein kinase 1 epsilon (CK1ε) for treating marginal zone lymphoma (MZL) and follicular lymphoma (FL). This study aimed to develop a fast and stable ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for quantitative analysis of umbralisib in rat plasma and its application for evaluating the effect of sophocarpine on the pharmacokinetics of umbralisib. A direct protein preparation with acetonitrile was used to deal with rat plasma. Umbralisib and duvelisib (internal standard, IS) were isolated on a Waters Acquity UPLC BEH C18 column with mobile phase consisted of acetonitrile and 0.1% formic acid in water. The linear range was from 0.5 to 1,000 ng/ml. Both of the precision (RSD%) and accuracy (RE%) were less than 15% in a permissible range. The mean recovery and matrix effect of umbralisib were 86.3–96.2% and 97.8–112.0%, respectively. When umbralisib was combined with sophocarpine, AUC0→∞ of umbralisib was significantly reduced to 2462.799 ± 535.736 ng/ml•h from 5416.665 ± 1,451.846 ng/ml•h, and Cmax also was markedly diminished. Moreover, CLz/F was increased more than two times. This developed, optimized and technical UPLC-MS/MS method was extremely suitable for detecting the concentrations of umbralisib in rat plasma after an oral administration, and sophocarpine significantly changed the pharmacokinetics of umbralisib in rats. This obvious pharmacokinetic changes indicates that there seems to exist herb-drug interaction between sophocarpine and umbralisib.
Medication Adherence in a Cross-Diagnostic Sample of Patients From the Affective-to-Psychotic Spectrum: Results From the PsyCourse Study
Authors: Kirchner Sophie-Kathrin , Lauseker Michael , Adorjan Kristina , Anderson-Schmidt Heike , Anghelescu Ion-George , Baune Bernhardt T. , Budde Monika , Dannlowski Udo , Dietrich Detlef E. , Fallgatter Andreas J. , Falkai Peter , Figge Christian , Gade Katrin , Heilbronner Urs , Hiendl Lena , Juckel Georg , Kalman Janos L. , Klöhn-Saghatolislam Farahnaz , Konrad Carsten , Lang Fabian U. , Oraki Kohshour Mojtaba , Papiol Sergi , Reich-Erkelenz Daniela , Reimer Jens , Reininghaus Eva Z. , Schaupp Sabrina K. , Schmauß Max , Schmitt Andrea , Schulte Eva Christina , Senner Simon , Spitzer Carsten , Vogl Thomas , Zimmermann Jörg , Hasan Alkomiet , Schulze Thomas G. , Senner Fanny 
Published: January 2022

IntroductionAccording to the World Health Organization, medication adherence is defined as the extent to which a person's behavior corresponds with an agreed recommendation from a healthcare provider. Approximately 50% of patients do not take their medication as prescribed, and non-adherence can contribute to the progress of a disease. For patients suffering from mental diseases non-adherence plays an important role. Various factors have been proposed as contributing to non-adherence, however the literature remains heterogeneous dependent on the analyzed patient subgroups. This study comprehensively evaluates the association of sociodemographic, clinical, personality and quality of life related factors with medication adherence by analyzing data from the PsyCourse study. The PsyCourse study is a large and cross-diagnostic cohort of psychiatric patients from the affective-to-psychotic spectrum.MethodsThe study sample comprised 1,062 patients from the PsyCourse study with various psychiatric diagnoses (mean [SD] age, 42.82 [12.98] years; 47.4% female). Data were analyzed to identify specific factors associated with medication adherence, and adherence was measured by a self-rating questionnaire. Odds ratios (OR) were estimated by a logistic regression for binary outcomes. Missing data were imputed using multiple imputation.ResultsThe following factors showed the strongest association with medication adherence: never having used illicit drugs (OR, 0.71), number of prescribed antipsychotics (OR, 1.40), the personality trait conscientiousness (OR, 1.26), and the environmental domain of quality of life (OR, 1.09).ConclusionIn a large and cross-diagnostic sample, we could show that a higher level of conscientiousness, a higher number of antipsychotic medication, a better quality of life within the environmental domain, and the absence of substance abuse contribute to a better medication adherence independent of the underlying disorder.
Association Between Subnational Vaccine Coverage, Migration, and Incident Cases of Measles, Mumps, and Rubella in Iraq, 2001–2016
Authors: Comfort Haley , Lafta Riyadh K. , Flaxman Abraham D. , Hagopian Amy , Duber Herbert C. 
Published: January 2022

ObjectiveThis analysis examines governorate-level disease incidence as well as the relationship between incidence and the number of persons of concern for three vaccine-preventable diseases—measles, mumps, and rubella—between 2001 and 2016.MethodsUsing Iraqi Ministry of Health and United Nations High Commissioner for Refugees (UNHCR) data, we performed descriptive analyses of disease incidence and conducted a pooled statistical analysis with a linear mixed effects regression model to examine the role of vaccine coverage and migration of persons of concern on subnational disease incidence.ResultsWe found large variability in governorate-level incidence, particularly for measles (on the order of 100x). We identified decreases in incident measles cases per 100,000 persons for each additional percent vaccinated (0.82, 95% CI: [0.64, 1.00], p-value &lt; 0.001) and for every additional 10,000 persons of concern when incorporating displacement into our model (0.26, 95% CI: [0.22, 0.30], p-value &lt; 0.001). These relationships were insignificant for mumps and rubella.ConclusionsNational level summary statistics do not adequately capture the high geospatial disparity in disease incidence between 2001 and 2016. This variability is complicated by MMR vaccine coverage and the migration of “persons of concern” (refugees) during conflict. We found that even when vaccine coverage was constant, measles incidence was higher in locations with more displaced persons, suggesting conflict fueled the epidemic in ways that vaccine coverage could not control.
Studi Tentang Motivasi Berprestasi Taruna Sekolah Tinggi Ilmu Pelayaran
Authors: Reknati Puji 
Published: January 2022

Penelitian ini bertujuan untuk mengetahui faktor-faktor apa yang mempengaruhi rendahnya motivasi berprestasi pada taruna STIP. Motivasi berprestasi yang dimaksud disini adalah kebutuhan dari seorang individu untuk menyelesaikan sesuatu yang sulit dengan baik dan mandiri, menghadapi rintangan dan mencapai standar yag tinggi, serta keberanian untuk bersaing
Pendekatan yang digunakan kombinasi kuantitatif dan kualitatif dengan subjek taruna STIP. Sampel diambil secara kebetulan yaitu taruna yang diajar peneliti pada semester genap 2020/2021,terdiri dari dua kelas semester delapan, satu kelas semester tujuh dan dua kelas semester empat dari tiga prodi yang ada di STIP. Pengumpulan data dilakukan dengan memberian pertanyaan terbuka pada responden kemudian analisis data dilakukan dengan pengelompokan responden pada faktor -faktor yang mempengaruhi motivasi berprestasi, baik faktor intrinsik yaitu kemungkinan untuk sukses, perasaan takut gagal, self efficacy , value dan pengalaman. Maupun faktor ekstrinsik yang terdiri dari lingkungan sekolah, keluarga dan teman. Disamping itu untuk kelengkapan data juga dilakukan wawancara terhadap beberapa taruna, dan dosen, mempelajari dokumen yang relevan dan observasi terhadap perilaku subjek.
Gambaran dari respon responden kemudian digunakan untuk pengajuan saran strategi peningkatan motivasi berprestasi taruna.
Upaya Mengatasi Gangguan Sistem Pembilasan Guna Menunjang Kelancaran Pengoperasian Mesin Induk Di Kapal MV. Lumoso Harmoni
Authors: Hartaya  , Herawati Susi , Komar Syarifuddin 
Published: January 2022

Sampai saat ini, mesin induk diesel masih mendominasi sebagai mesin penggerak utama kapal. Oleh karena itu kinerja pengoperasiannya sangatlah penting dalam menunjang kelancaran pengoperasian kapal itu sendiri. Daya yang dihasilkannya sangat bergantung besar pada kualitas pembakaran yang terjadi di dalam silinder. Hal tersebut dapat dipengaruhi oleh beberapa faktor antara lain : jumlah dan kualitas bahan bakar yang disuplai, kualitas dan kuantitas udara bilas yang masuk ke dalam silinder, kondisis ruand kompresi serta sistem-sistem pendukung laninnya. Pada kapal MV.Lumoso terjadi gangguan dalam pengoperasian mesin induk terkait pada sistem pembilasan, yaitu pengisian udara bilas yang masuk ke dalam silinder untuk proses pembakaran. Hal ini sangat mempengaruhi terjadinya penurunan putaran mesin induk dan pada gilirannya mengakibatkan penurunan daya serta kecepatan kapal. Permasalahan yang terjadi di kapal MV Lumoso Harmoni di antaranya yaitu terjadinya surging pada turbocharger, penyumbatan pada saringan udara, tekanan udara bilas menurun, temperatur udara bilas lebih tinggi dari yang seharusnya, terbatasnya waktu untuk perawatan secara berkala dan pendinginan pada intercooler tidak maksimal. Kondisi ini sangat mepengaruhi opersional kapal, di mana rencana jadual keberangkatan maupun kedatangannya di pelabuhan menjadi terganggu Maka hal inilah yang mendasari penulisan penelitian ini, bagaimana strategi untuk mengatasi gangguan pada kasus mesin induk kapal MV Lumoso Harmoni. Agar dapat bermanfaat sumbangan pemikiran bagi rekan-rekan Ahli Mesin Kapal, bila mengalami kasus serupa di tempat kerjanya.
Religiosidade e/ou espiritualidade como fatores de proteção ao uso de álcool entre adolescentes: revisão sistemática
Authors: Clarindo Celestino Lázaro , Fukushiro Ana Paula , Sharllene Carneiro da Silva Andressa , Ferreira Santiago Júnior Joel , Dos Santos Trettene Armando 
Published: January 2022

Objetivo: identificar evidências da influência da religiosidade e/ou espiritualidade como fatores de proteção ao uso de álcool em adolescentes. Método: Revisão Sistemática da Literatura. Bases elegíveis: PubMed, Lilacs, Cinahl e Embase. Cadastrou-se, esta revisão no banco de dados PROSPERO, que recebeu protocolo nº CRD42020188122, e seguiu a adequação do protocolo PRISMA. A busca inicial resultou em 1.180 artigos. Após a leitura dos títulos e resumos, restaram 179 artigos. Após aplicação dos critérios de inclusão e exclusão, foram selecionados 09 estudos finais. Resultados: Identificou-se, a religiosidade e espiritualidade como um importante fator de proteção aos adolescentes contra o uso do álcool. Conclusão: como sugerem os resultados deste estudo, a religiosidade e a espiritualidade configuraram-se como fatores de proteção ao uso do álcool por adolescentes. Nesse sentido, se pesquisas adicionais apoiarem essa hipótese, a identificação de tais adolescentes será importante para destinar prioritariamente os esforços de prevenção. Não obstante, o grande desafio é traduzir esses achados em programas eficazes de prevenção.
Sentralitas Aktor dan Distribusi Jaringan Komunikasi Kelompok Prostitusi di Media Sosial Twitter
Authors: Tayibnapis Radita Gora , Tarsani Oni 
Published: January 2022

Fenomena prostitusi di Indonesia kian menggeliat, di masa COVID 19 para pelaku prostitusi semakin menyebar dengan membentuk jaringan-jaringan baru perdagangan wanita di media sosial. Pembentukan jaringan di media sosial semakin memudahkan para pelaku prostitusi membentuk kelompok dan subkelompok baru sehingga akses untuk melakukan komunikasi antarpelaku prostitusi semakin mudah di media sosial. Upaya untuk menganalisis, peneliti menggunakan Teori Jaringan Sosial untuk menganalisis jaringan komunikasi antarpelaku prostitusi dan Computer Mediated Communication (CMC) untuk mendalami permasalahan perluasan jaringan dan pembentukan jaringan melalui metode campuran sekuensial eksplanatori. Berdasarkan hasil penelitian menunjukkan bahwa para pelaku prostitusi dapat melakukan perluasan jaringan secara masif melalui jaringan media sosial yang sudah meluas transaksi jaringannya. Selain itu, para pelaku prostitusi online di Twitter tersebar di seluruh kota di Jawa bahkan jaringan tersebut juga dapat meluas hingga luar Pulau Jawa. Motif dari perdagangan jasa seksual online ini tidak terlepas dari kebutuhan ekonomi.
Kata kunci: prostitusi, sentralitas aktor, subkelompok, metode campuran, jaringan komunikasi
THEODOR FONTANE’S NOVEL “EFFI BRIESTˮ: PSEUDO-GOTHIC FEATURES
Authors: Алексеева Марина Геннадьевна 
Published: January 2022

В статье исследуются жанровые особенности супружеского романа Теодора Фонтане “Effi Briestˮ. Роман, жанр которого определяется как поэтический реализм, изобилует псевдоготическими элементами. Их вычленение, установление значимости межжанровых вкраплений обусловливает актуальность исследуемой проблемы. В результате применения метода лингвистического анализа текста в работе были выделены и описаны признаки готического романа, актуализированные писателем в виде клишированных амплуа героев - злодей и юная жертва, клишированных мотивов - путешествия, мотив экзотики, мотивы сна и сновидений, в виде типичных топологических маркеров - прóклятое место и в каноническом стержне романа - преступлении или исчезновении какого-либо героя в прошлом. Элементы готического романа переоцениваются в дальнейшем повествовании, они последовательно нейтрализуются главными героями, при этом выявляются дополнительные личностные характеристики главных персонажей, например, «мистицизм» барона Инштеттена, его страсть воспитывать окружающих, в том числе методом запугивания. Нивелирование и изымание из повествования готических элементов, действия героев вопреки готическим канонам, например, желание Эффи вернуть «счастливые дни в доме с привидениями» или примирение, пусть и через посредников, «злодея» и «жертвы», способствуют выделению признаков жанра «поэтический реализм», подчеркивают критическую оценку Т. Фонтане Прусской Германии, противопоставление гуманистического начала прогрессу, власти и культуре.
This article explores the genre features of Theodor Fontane’s marital novel “Effi Briestˮ. The novel, the genre of which is defined as poetic realism, is replete with pseudo-gothic elements. The identification of those elements and ascertainment of the significance of inter-genre inclusions make the problem under research relevant. The method of linguistic analysis of the text made it possible to identify and describe the features of the Gothic novel actualized by the writer in the form of clichéd characters (the villain and the young victim), clichéd motives(travel, exotic motive, motives of sleep and dreams), typical topological markers(cursed place), and the canonical core of the novel (the crime or disappearance of a character in the past). The elements of the Gothic novel are reevaluated in the further narrative, they are consistently neutralized by the main characters, while revealing additional personal characteristics of the main characters, such as ‘mysticism’ of Baron Instetten, his passion to educate others, even employing intimidation. Neutralization and removal of Gothic elements from the narrative, the actions of the characters contrary to Gothic canons, such as Effie’s desire to return ‘happy days in a haunted house’ or the reconciliation, even through intermediaries, of ‘villain’ and ‘victim’, contribute to the identification of signs of the genre ‘poetic realism’, emphasize T. Fontane’s critical assessment of Prussian Germany, the opposition of the humanist principle to progress, power and culture.
FORMATION OF SELF-CONTROL AMONG SENIOR SCHOOLCHILDREN IN STUDYING A FOREIGN LANGUAGE WITH THE HELP OF LEARNING DIARY
Authors: Хрисанова Елена Геннадьевна , Савельева Анна Ивановна 
Published: January 2022

В статье рассматривается проблема формирования самоконтроля у обучающихся старших классов в процессе изучения иностранного языка. Показана актуальность данного вопроса, подтверждаемая научными изысканиями А. А. Крылова, С. Д. Якушевой, Г. К. Селевко, значимостью самоконтроля для самостоятельной учебной деятельности старшеклассников в целом и изучения иностранного языка в частности. Представлены результаты проведенного в ряде общеобразовательных школ г. Чебоксары исследования самоконтроля учебной деятельности старшеклассников: зависимость его эффективности от проявляемого к изучению того или иного предмета интереса и учебной мотивации; завышенная самооценка уровня сформированности самоконтроля учебной деятельности, демонстрируемая школьниками. В качестве технологии формирования самоконтроля у старшеклассников предложено ведение дневника учебных достижений. Раскрывается возможная структура такого дневника, включающая цели изучения иностранного языка, календарь на учебный год, календарь на каждый месяц в году, календарь на отдельные недели месяца, систему отслеживания (трекер) на месяц и др. Приводится пример ведения дневника учебных достижений в процессе подготовки к сдаче ЕГЭ по иностранному языку. Даны комментарии и рекомендации для педагогов по формированию у старшеклассников самоконтроля в учебной деятельности с использованием дневника учебных достижений.
The article discusses the problem of formation of self-control in senior students in the process of learning a foreign language; shows the urgency of this problem confirmed by the scientific research works of A. A. Krylov, S. D. Yakusheva, G. K. Selevko, and the importance of self-control skills for independent learning activities of senior schoolchildren in general and studying a foreign language in particular. The work also presents the results of the study of senior pupils’ educational activity self-control, conducted in a number of secondary schools in Cheboksary. The study demonstrated the dependence of self-control effectiveness on the interest in a particular subject and educational motivation; overestimated self-esteem of the level of educational activity self-control demonstrated by schoolchildren. The authors suggest keeping a learning diary for the formation of self-control among senior schoolchildren; provide a structure of such a diary including the goals of learning a foreign language, a calendar for an academic year, a calendar for every month of the year, a calendar for individual every week of the month; a tracking system (tracker) for a month, etc. They also present an example of keeping a leaning diaryin the process of preparing for the USE in a foreign language. The comments and recommendations are given for teachers on the formation of senior schoolchildren’s skills of self-control of educational activities using a learning diary.