bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liver transplantation in rare late‐onset ornithine transcarbamylase deficiency with central nervous system injury: A case report and review of the literature
Authors: Jin Xin , Zeng Xinchen , Zhao Dong , Jiang Nan 
Published: September 2022

AbstractBackgroundOrnithine transcarbamylase deficiency (OTCD) is a genetic metabolic disease. Its clinical manifestations are mainly central nervous system dysfunction caused by high blood ammonia. Late‐onset OTCD combined with central nervous system injury has a poor therapeutic response, which is one of the main factors affecting the prognosis and quality of life of patients. liver transplantation (LT) has gradually become a radical treatment for OTCD, which has achieved good results. However, there is no consensus on the timing of LT and problems of nervous system damage and repair.MethodsWe report the development of late‐onset OTCD with central nervous system injury in an 11‐year‐old child who received liver transplantation at our transplant center. His first symptoms were nonprojectile vomiting, followed by irritability and disturbance of consciousness, after which the disease progressed rapidly and finally resulted in a coma. After liver transplantation, the child's consciousness returned to normal, muscle strength of the limbs gradually recovered from grade 0 to grade 4, and muscle tone gradually recovered from grade 4 to grade 1, suggesting that the motor nerves had gradually recovered. However, the child is currently mentally retarded, and the language center has not yet fully recovered.At the same time, we made a literature review of OTCD.ConclusionFor OTCD patients with central nervous system injury, liver transplantation can fundamentally solve the problem of ammonia metabolism in the liver and avoids further damage to the central nervous system caused by hyperammonemia. At the same time, children's nervous systems are in the developmental stage when neuroplasticity is greatest. If liver transplantation is performed as soon as possible, nerve repair is still possible.
Herpes zoster prophylaxis: Essential for treating newly diagnosed multiple myeloma patients
Authors: Lin Wen‐Ying , Tsai Chun‐Kuang , Yeh Chiu‐Mei , Chian Tin , Liu Yao‐Chung , Wang Hao‐Yuan , Ko Po‐Shen , Lin Ting‐An , Hsiao Liang‐Tsai , Chen Po‐Min , Gau Jyh‐Pyng , Liu Chia‐Jen 
Published: September 2022

AbstractBackgroundMultiple myeloma (MM) is known for its immune disturbance and patients suffering from MM are thus vulnerable to opportunistic infections, including herpes zoster (HZ). As HZ infection remarkably affects patients' quality of life and poses huge economic burdens on the health system, we aim to identify the risk factors of HZ infection and evaluate the effects of different dosages, types, and durations of anti‐HZ prophylaxis drugs to prevent HZ infection.Methods551 MM patients at Taipei Veterans General Hospital in Taiwan between January 1, 2009 and August 31, 2021 were restrospectively analyzed. The patients' baseline characteristics were recorded. The primary endpoint of the study was the incidence of HZ infection among the studied patient population. Due to the lack of cost coverage from Taiwanese public health insurance on HZ prophylaxis drugs, the use of anti‐HZ drugs mainly depends on physicians' preferences and patients' choices.ResultsIn our study, prophylaxis was given to 283 of the patients. In the multivariate analysis, we included non‐prophylaxis, age ≥ 60, corrected serum calcium ≥12 mg/dl, serum creatinine ≥2 mg/dl, serum β2‐microglobulin ≥5500 mg/L, autologous stem cell transplant (SCT), and allogeneic SCT for analysis. Our results demonstrated that the non‐prophylaxis group (HR: 2.37, 95% CI 1.57–3.57) and patients receiving autologous SCT (HR: 2.22, 95% CI 1.28–3.86) and allogeneic SCT (HR: 5.12, 95% CI 1.13–23.22) had higher risk of HZ infection. The difference in dosage and types of anti‐HZ drugs showed similar protective effects. In patients who stopped anti‐HZ prophylaxis before active cancer‐related treatment, a higher risk of getting HZ infection compared to the corresponding group was also observed (adjusted HR 3.09, 95% CI 1.35–7.07, p = 0.008).ConclusionsWe concluded that MM patients should receive HZ prophylaxis drugs while receiving active cancer‐related treatment. Patients receiving SCT are also at high risk of getting HZ infection, even under prophylaxis.
Risk of metachronous contralateral breast cancer in patients with primary invasive lobular breast cancer: Results from a nationwide cohort
Authors: Akdeniz Delal , Kramer Iris , van Deurzen Carolien H. M. , Heemskerk‐Gerritsen Bernadette A. M. , Schaapveld Michael , Westenend Pieter J. , Voogd Adri C. , Jager Agnes , Steyerberg Ewout W. , Sleijfer Stefan , Schmidt Marjanka K. , Hooning Maartje J. 
Published: September 2022

AbstractLobular primary breast cancer (PBC) histology has been proposed as a risk factor for contralateral breast cancer (CBC), but results have been inconsistent. We investigated CBC risk and the impact of systemic therapy in lobular versus ductal PBC. Further, CBC characteristics following these histologic subtypes were explored. We selected 74,373 women diagnosed between 2003 and 2010 with stage I‐III invasive PBC from the nationwide Netherlands Cancer Registry. We assessed absolute risk of CBC taking into account competing risks among those with lobular (n = 8903), lobular mixed with other types (n = 3512), versus ductal (n = 62,230) histology. Hazard ratios (HR) for CBC were estimated in a cause‐specific Cox model, adjusting for age at PBC diagnosis, radiotherapy, chemotherapy and/or endocrine therapy. Multivariable HRs for CBC were 1.18 (95% CI: 1.04–1.33) for lobular and 1.37 (95% CI: 1.16–1.63) for lobular mixed versus ductal PBC. Ten‐year cumulative CBC incidences in patients with lobular, lobular mixed versus ductal PBC were 3.2%, 3.6% versus 2.8% when treated with systemic therapy and 6.6%, 7.7% versus 5.6% in patients without systemic therapy, respectively. Metachronous CBCs were diagnosed in a less favourable stage in 19%, 26% and 23% and less favourable differentiation grade in 22%, 33% and 27% than the PBCs of patients with lobular, lobular mixed and ductal PBC, respectively. In conclusion, lobular and lobular mixed PBC histology are associated with modestly increased CBC risk. Personalised CBC risk assessment needs to consider PBC histology, including systemic treatment administration. The impact on prognosis of CBCs with unfavourable characteristics warrants further evaluation.
Financial toxicity of patients with lung cancer in China: Results from a National Survey Study
Authors: Liu Meicen , Huang Dengmin , Liu Yuanli 
Published: September 2022

AbstractObjectiveTo develop a comprehensive understanding of financial toxicity (FT) among patients with lung cancer in China and the major factors affecting FT.MethodsDrawing from a national cross‐sectional survey, which used the validated comprehensive score for financial toxicity (COST) questionnaire, we estimated the prevalence and degree of FT. Patient coping actions were investigated. Pearson's chi tests and multinomial logistic regression were used to evaluate the predictors of FT in patients with lung cancer.ResultsThe median score of FT was 20 (scored on a range of 0–44, with lower scores indicating more severe toxicity). Altogether, 77% of the sample patients had FT (COST <26), 54.5% had mild FT (COST 14–25), and 22.5% had moderate and severe FT (COST 0–13). Living in the less‐developed western region of China, being male, having a lower educational level, lower annual family income, and advanced stage or worse self‐reported health status were significantly related to higher FT than their counterparts (p < 0.05). Patients with higher FT tended to have a lower level of medical compliance, a higher risk of incurring debts, and reduced living expenditures relative to those with lower FT.ConclusionDespite China's remarkable progress in the past two decades with regard to Universal Healthcare Coverage, FT still presents a serious challenge for patients with lung cancer. Keen attention must be paid to reducing the disproportionate high financial risks of patients with low socioeconomic status.
Phenolic Glucosides from the Leaves of Vitex negundo var. cannabifolia
Authors: Sun Jing , Li Manman , Wang Yongru , Chang Chuang , Pei Yujie , Zeng Kewu , Zhao Yunfang , Zheng Jiao , Song Yuelin , Tu Pengfei , Huo Huixia , Li Jun 
Published: September 2022

AbstractFour new phenolic glucosides, cannabifolins G–J (1–4), together with four known ones (5–8), were isolated from the leaves of Vitex negundo var. cannabifolia. Their structures were established by comprehensive analysis of 1D and 2D NMR data and comparison of their spectroscopic and physical data with the literature values. Compound 7 exhibited weak inhibition of nitric oxide production stimulated by lipopolysaccharide in BV‐2 microglial cells with IC50 value of 132.8 μM.
LaCoxFe1‐xO3‐δ‐QDs/CNTs Composite as an Efficient Electrocatalyst for Oxygen Evolution Reaction
Authors: Yang Haidong , Wang Qianyi , Ren Jiajia , Chang Shan , Zhang Yongfeng 
Published: September 2022

AbstractOxygen evolution reaction (OER) is a critical half‐reaction in the process of electrochemical water splitting, which has been researched a lot in last few years. Nevertheless, OER has high overpotential and sluggish reaction kinetics. Therefore, preparing non‐noble metal catalysts with high surface activity to decrease the activation energy of the reaction is the key to solving these problems. Herein, we report a facile development of an electrocatalyst for OER. The composites of perovskite oxide quantum dots with abundant oxygen vacancies attached to oxidized carbon nanotubes (LaCoxFe1‐xO3‐δ‐QDs/CNTs) were manufactured by sodium borohydride reduction method. The results evidence that the optimized LaCo0.5Fe0.5O2.603‐QDs/CNTs sample exhibits optimal electrocatalytic performance (with an overpotential of 210 mV at 10 mA/cm2) and prominent stability towards OER. It should attribute to quantum dots structure, suitable Co/Fe ratio, fitting calcination temperature, appropriate oxygen vacancy concentration. This work will offer novel inspiration for the research and evolution of non‐precious metal catalysts with improved performance.
Silver‐Based Conductive Ink on Paper Electrodes Based on Micro‐Pen Writing for Electroanalytical Applications
Authors: Zhao Chen‐Fei , Wang Jun , Zhang Zhuo‐Qing , Sun Zhao , Maimaitimin Zuliaya 
Published: September 2022

AbstractNano‐silver conductive inks have attracted the attention of researchers due to their high electrical conductivity, good chemical stability, and wide applicability. As the mainstream conductive ink, it is mostly used in inkjet printing, but its application is limited due to the high sintering temperature. In this paper, silver nanoparticles were synthesized by reducing silver nitrate with sodium borohydride. Using silver nanoparticles as basic conductive fillers and graphene or copper nanoparticles as auxiliary conductive fillers, silver conductive inks, silver/graphene conductive inks and silver/copper conductive inks suitable for micro‐direct writing printing were prepared. Electrode patterns were printed on photo paper by micro‐pen writing printing. The prepared paper electrode can detect nitrate using electrochemical analysis. The results show that the paper electrodes prepared with the three conductive inks can be used for the analysis of potassium ferricyanide and potassium nitrate. The minimum square resistance of paper electrodes prepared with silver conductive ink is 0.11 Ω/sq. It can be cycled 60 times in electrochemical applications with small standard deviation and high reproducibility and stability. Analysis and detection can also be performed in nitrate concentrations ranging from 60 μM to 1000 μM. This low silver‐containing, green, and low resistivity flexible electrode offers a solution for the simplicity and economy of electronic devices.
Electrophotochemical Metal‐Catalyzed Decarboxylative Coupling of Aliphatic Carboxylic Acids
Authors: Yang Kai , Lu Jiaqing , Li Liubo , Luo Sanzhong , Fu Niankai 
Published: September 2022

AbstractAn electrophotochemical dual metal‐catalyzed protocol for decarboxylative arylation of simple aliphatic carboxylic acids with aryl halides is reported. The relative stabilities of catalytically active metal complexes simultaneously generated at anode and cathode are the key design elements for the success of this convergent paired electrolysis. This new electrophotocatalytic method is mild, robust, and most importantly, capable of accommodating simple primary aliphatic acids including acetic acid – ubiquitous and variegated structural motifs yet remain oddly challenging substrates – directly as native functional groups for decarboxylative C(sp2)−C(sp3) bond formation.
Peri‐Functionalized Tetraazaperylenes: Strong Emitters for Molecular Polaritonics
Authors: Wesp Tobias , Valsalan Parvathi , Kochan Alexander , Hertzog Manuel , Wadepohl Hubert , Zaumseil Jana , Gade Lutz H. 
Published: September 2022

AbstractThe functionalization of the peri position of the bay chlorinated tetraazaperylene was investigated by varying the donor behavior of the substituents to assess the resulting photophysical and electrochemical properties. To accomplish this, electron donating alkyl‐ and arylsulfido substituents, methoxy and methyl groups were selectively introduced into the peri position via a nucleophilic aromatic substitution of the perchlorinated tetraazaperylene. Both the alkylated and benzylated thioethers displayed high fluorescence quantum yields of up to 80 %. Compounds from the latter group were integrated in resonant optical microcavities to achieve strong light‐matter coupling. The formation of exciton‐polaritons was observed by angle‐dependent reflectivity and photoluminescence that could be tuned by variation of the concentration of the fluorophores and of the thickness of the cavity.
A Porous Polyaromatic Solid for Vapor Adsorption of Xylene with High Efficiency, Selectivity, and Reusability
Authors: Sumida Ryuki , Matsumoto Takeshi , Yokoi Toshiyuki , Yoshizawa Michito 
Published: September 2022

AbstractDevelopment of porous materials capable of capturing volatile organic compounds (VOCs), such as benzene and its derivatives, with high efficiency, selectivity, and reusability is highly demanded. Here we report unusual vapor adsorption behavior toward VOCs by a new porous solid, composed of a polyaromatic capsule bearing a spherical nanocavity with subnano‐sized windows. Without prior crystallization and high‐temperature vacuum drying, the porous polyaromatic solid exhibits the following five features: vapor adsorption of benzene over cyclohexane with 90 % selectivity, high affinity toward o‐xylene over benzene and toluene with >80 % selectivity, ortho‐selective adsorption ability (>50 %) from mixed xylene isomers, tight VOCs storage even under high temperature and vacuum conditions, and at least 5 times reusability for xylene adsorption. The observed adsorption abilities are accomplished at ambient temperature and pressure within 1 h, which has not been demonstrated by organic/inorganic porous materials reported previously.
Auto‐thermal chemical looping combustion of sulphur with Fe2O3 oxygen carriers for sulphuric acid production: Thermodynamics
Authors: Gao Peng , Shen Yue , Zheng Min , Bao Guirong , Wang Hua , Xie Haitao , Wang Lulu 
Published: September 2022

AbstractChemical looping is a novel fuel conversion and material separation technology. It can be applied to obtain sulphur through selective oxidation of H2S. Further, chemical looping combustion (CLC) of sulphur can generate SO2 with a high concentration without NOx formation. The high SO2 concentration is adjustable and facilitates large‐scale H2SO4 production. In this study, we examined the thermodynamics of the CLC of sulphur for H2SO4 production, which has not been reported previously. We analyzed the effects of reactor temperature and sulphur to Fe2O3 oxygen carrier (OC) ratios on sulphur allotrope transformations and on the distributions of reaction products. Moreover, the reactors were operated auto‐thermally. Based on this design, we examined the effects of fuel reactor (FR) and air reactor temperatures on the minimum recirculation of the OC, as well as the gas and solid products and heat released from the air reactor. Our results showed that the CLC of sulphur with Fe2O3 OC could occur through an auto‐thermal process. The FR in a sulphur CLC system should be operated over a temperature range of 800–950°C, with an Fe2O3 OC recirculation between 45 and 143 kg/kgS(s). Furthermore, when the FR was operated in the auto‐thermal mode, we achieved 100% SO2 conversion. The findings of this study may be applied to reactor design for large‐scale H2SO4 production through CLC of sulphur.
Reactivity stabilization and capacity study of fabricated alumina and zirconia‐supported CaO‐based sorbents for high‐temperature CO2 capture in a fixed‐bed reactor
Authors: Mohammadi Mahshid , Sedghkerdar Mohammad Hashem , Abbasi Mohsen , Izadbakhsh Ali , Karami Davood 
Published: September 2022

AbstractCalcium looping process is a promising approach for CO2 capture from the flue gas of fossil fuel power plants and the cement industry. Even though the advantages of calcium‐based sorbents are low cost and high uptake capacity, they suffer from low durability during cycles. Modified sorbents were fabricated by adding alumina and zirconia and the mixture of alumina and zirconia to calcium oxide via the co‐precipitation method. The performance of synthesized sorbents in terms of stability and CO2 capture capacity were evaluated using a fixed bed reactor in various CO2 sorption/desorption cycles. The sorbents were fabricated by a co‐precipitation methodology using 10% binders (alumina and/or silica). X‐ray diffraction (XRD), BET/BJH, and scanning electron microscopy (SEM) were conducted for characterization of synthesized sorbents. CaO‐10% ZrO2 showed the best performance among the fabricated sorbents in terms of stability during 5 cycles and CO2 capacity (14 mmol CO2/g sorbent). The formation of CaZrO3 with a perovskite structure and high‐temperature resistance could be attributed to well performance of zirconia‐supported sorbent. On the other hand, no sign of aluminum zirconate formation was approved in XRD analysis for the fabricated sorbent using mixed binders of zirconia and alumina to enhance its stability during cycles.
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2
Authors: Laleu Benoît , Rubiano Kelly , Yeo Tomas , Hallyburton Irene , Anderson Mark , Crespo‐Fernandez Benigno , Gamo Francisco‐Javier , Antonova‐Koch Yevgeniya , Orjuela‐Sanchez Pamela , Wittlin Sergio , Jana Gouranga P. , Maity Bikash C. , Chenu Elodie , Duffy James , Sjö Peter , Waterson David , Winzeler Elizabeth , Guantai Eric , Fidock David A. , Hansson Thomas G. 
Published: September 2022

AbstractNew antimalarial treatments with novel mechanism of action are needed to tackle Plasmodium falciparum infections that are resistant to first‐line therapeutics. Here we report the exploration of MMV692140 (2) from the Pathogen Box, a collection of 400 compounds that was made available by Medicines for Malaria Venture (MMV) in 2015. Compound 2 was profiled in in vitro models of malaria and was found to be active against multiple life‐cycle stages of Plasmodium parasites. The mode of resistance, and putatively its mode of action, was identified as Plasmodium falciparum translation elongation factor 2 (PfeEF2), which is responsible for the GTP‐dependent translocation of the ribosome along mRNA. The compound maintains activity against a series of drug‐resistant parasite strains. The structural motif of the tetrahydroquinoline (2) was explored in a chemistry program with its structure‐activity relationships examined, resulting in the identification of an analog with 30‐fold improvement of antimalarial asexual blood stage potency.
Energy‐efficient computation offloading and resource allocation in delay‐constrained vehicular edge network
Authors: Yang Junchao , Lin Feng , Saini Dinesh Kumar , Zhu Yanyan , Li Yu , Guo Zhiwei 
Published: September 2022

SummaryCellular vehicular‐to‐everything (C‐V2X), as a key technology of Internet of Vehicles (IoV), is promised to be enhanced and strengthened to improve road traffic safety and achieve intelligent transportation in 6G era. However, computation‐intensive and latency‐sensitive computation tasks of autonomous driving create a great challenge for the computation and storage limited vehicles. Fortunately, mobile edge computing (MEC) architecture offers a possible solution for the challenge. In this paper, a joint computation offloading and resource allocation algorithm is proposed to solve the computation tasks offloading problem in the scenario of vehicular edge computing network. First, the computation offloading and resource allocation are jointly modeled as a mixed integer nonlinear optimization problem. Aiming at minimizing the total system cost (weighted sum of delay and energy consumption), a particle encoding method and a particle refinement algorithm are proposed based on the compression factor particle swarm optimization, and multilevel penalty function is adopted to deal with the constraints of the objective. Finally, experimental performances validate the effectiveness and feasibility of the proposed algorithm.
Electrosurgical knife with the water‐jet function of tip‐type during endoscopic treatment injection
Authors: Ono Satoshi , Kurihara Yasuko , Hirose Fumiya , Aoki Hajime , Maejima Kyohei , Ito Shun , Osumi Shun , Hatori Seika , Fukagawa Kazushi , Hosaka Shosuke , Matsukawa Miho , Kobayashi Ryosuke , Yamazaki Nobuyoshi , Fujishiro Mitsuhiro 
Published: September 2022

AbstractObjectivesThis study aimed to objectively evaluate the water‐jet‐functioned electrosurgical knife injection performances in a desktop experiment.MethodsFive types of water‐jet‐functioned electrosurgical knives, including two injection styles of sheath‐type (A: DualKnife J, KD‐655L; B: FlushKnife, DK2620‐J‐B20S; C: Splash M‐Knife, DN‐D2718B; D: ISSEN, SN1650‐20) and tip‐type (E: ORISE ProKnife, M00519361) were evaluated. These knives were compared with an injection needle (Control: SuperGrip 25G) as a control. The injection speed under constant pressure and the injection efficiency for each knife against prepared porcine stomach mucosa were evaluated. The additional clear gel injections using an injection needle were observed using an indigo blue‐colored gel to evaluate the difference between the locations of water‐jet holes.ResultsFour types of knives, except for A, showed significantly higher water‐jet speeds (A: 0.79 ± 0.03 g/20 s, B: 2.56 ± 0.05 g/20 s, C: 3.09 ± 0.06 g/20 s, D: 2.86 ± 0.05 g/20 s, and E: 1.79 ± 0.03 g/20 s) compared to that of the control (1.21 ± 0.03 g/20 s). Meanwhile, significantly higher efficacy of injection was found in the tip‐type water‐jet function knife, second to the injection needle (Control: 37.2% ± 35.5%, A: 20.9% ± 20.2%, B: 1.1% ± 2.2%, C: 6.2% ± 12.6%, D: 12.5% ± 15.6%, and E: 33.3% ± 32.2%). An additional injection experiment revealed that the injection with a piercing tip into the gel could achieve sufficient additional injection inside the stacked clear gel.ConclusionsThe tip‐type water‐jet function electrosurgical knife is preferable for effective submucosal injection during endoscopic treatments.