bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC
Authors: Liu Kangdong , Li Mingzhu , Duan Lina , Wu Wenjie , Li Wenjing , Zhao Lili , Li Ang , Lu Xuebo , He Xinyu , Dong Zigang , Jiang Yanan 
Published: May 2022

Abstract
Gastric cancer is the fourth leading cause of cancer deaths worldwide. Most patients are diagnosed in the advanced stage, and inadequate therapeutic strategies and the high recurrence rate leads to the poor 5-year survival rate. Therefore, effective chemoprevention drugs for gastric cancer are urgently needed. Repurposing clinical drugs is an effective strategy for cancer chemoprevention. In this study, we found vortioxetine hydrobromide, an FDA-approved drug, is a dual JAK2/SRC inhibitor, and has inhibitory effects on cell proliferation of gastric cancer. Computational docking analysis, pull-down assay, cellular thermal shift assay (CETSA) and in vitro kinase assays were used to illustrate whether vortioxetine hydrobromide directly bound to JAK2 and SRC kinases and inhibited their kinase activities. The results of non-reducing SDS-PAGE and Western blotting indicated that vortioxetine hydrobromide suppressed STAT3 dimerization, nuclear translocation and transcriptional activity. Furthermore, vortioxetine hydrobromide inhibited the cell proliferation dependent on JAK2 and SRC gene expression and suppressed the growth of gastric cancer PDX model in vivo. These data demonstrated that vortioxetine hydrobromide, as a novel dual JAK2/SRC inhibitor, curbed the growth of gastric cancer in vitro and in vivo by JAK2/SRC-STAT3 signaling pathways. It highlights that vortioxetine hydrobromide has the potential application in the chemoprevention of gastric cancer.
Use of Theatresports to Promote Positive Education Among Youth Participants
Authors: Chan Gloria Hongyee , Lo T.Wing , Fung Johnny S.C. 
Published: May 2022

Abstract
This study examined the application of theatresports to promote positive education in youth work settings, with the overall objective of fostering young people’s all-round development. To this end, qualitative research was conducted with 92 participants in a theatresports program. Thematic analysis was applied to analyze the participants’ feelings about the program. Overall, the participants perceived the program positively. They acquired various capabilities, including skills that were interpersonal (e.g., social) and intrapersonal (e.g., self-reflection, problem-solving, multi-perspective thinking). They also achieved a positive identity, received peer support, and developed a sense of belonging to the program. Among the implications of the program, practitioners should provide additional support to consolidate participants’ experience and thereby maximize their personal growth.
GediNET- Discover Disease-Disease Gene Associations utilizing Knowledge-based Machine Learning
Authors: Yousef Malik , Qumsiyeh Emma 
Published: May 2022

Abstract
Most gene expression studies aim to discover genes associated with specific diseases. The standard approaches based on machine learning utilize several feature selection techniques to identify significant genes that can serve as biomarkers for a given disease. In recent times, the integration of prior knowledge-based approaches for biomarker identification has shown much promise in discovering several biomarkers, thus allowing scope for an increase in translational applications. In this study, we developed a novel approach GediNET that integrates prior biological knowledge about genes associated with diseases like cancer to group genes into groups. The novelty of GediNet is that it discovers disease-disease gene associations within groups rather than disease-gene associations. These groups are later subject to a Scoring component for performing group selections rather than single feature selection. The top-ranked groups are used to train the machine learning model. The process of Grouping and Scoring using the (G-S-M) model is then applied to discover groups of disease genes or biomarkers for a specific disease. One of the outputs of the suggested tool GediNET is a list of significant groups of diseases that combine their associated genes can contribute to developing biomarkers and drugs. GediNET identifies the relationships between diseases, Disease–disease association (DDA) based machine learning, which explores novel associations of diseases that enhance knowledge of disease relationships, which could further improve approaches to disease diagnosis, prognosis, and treatment. The GediNET Knime workflow can be downloaded from: https://github.com/malikyousef/GediNET.git or https://kni.me/w/3kH1SQV_mMUsMTS- .
Resilience of females to acute blood-brain barrier damage and anxiety behavior following mild blast traumatic brain injury
Authors: Hubbard Brad , Velmurugan Gopal V. , Brown Emily , Sullivan Patrick G. 
Published: May 2022

Abstract
Low-level blast exposure can result in neurological impairment for military personnel. Currently, there is a lack of experimental data using sex as a biological variable in neurovascular outcomes following blast exposure. To model mild blast traumatic brain injury (mbTBI), male and female rats were exposed to a single 11psi static peak overpressure blast wave using the McMillan blast device and cohorts were then euthanized at 6h, 24h, 7d, and 14d post-blast followed by isolation of the amygdala. After mbTBI, animals experience immediate bradycardia, although no changes in oxygen saturation levels or acute weight loss. Male mbTBI animals displayed significantly higher levels of anxiety-like behavior (open field and elevated plus maze) compared to male sham groups; however, there was no anxiety phenotype in female mbTBI animals. Blast-induced neurovascular damage was explored by measuring expression of tight junction (TJ) proteins (zonula occludens-1 (ZO-1), occludin and claudin-5), glial fibrillary acidic protein (GFAP) and astrocyte end-feet coverage around the blood-brain barrier (BBB). Western blot analysis demonstrates that TJ protein levels were significantly decreased at 6h and 24h post-mbTBI in male rats, but not in female rats, compared to sham. Female animals have decreased GFAP at 6h post-mbTBI while male animals display decreased GFAP expression at 24h post-mbTBI. By 7d post-mbTBI, there were no significant differences in TJ or GFAP levels between groups in either sex. At 24h post-mbTBI, vascular integrity and astrocytic end-feet coverage around the BBB was significantly decreased in males following mbTBI. These results demonstrate that loss of GFAP expression may be due to astrocytic damage at the BBB. Our findings also demonstrate sex differences in acute vascular and behavioral outcomes after single mbTBI. Female animals display a lack of BBB pathology after mbTBI corresponding to improved acute neuropsychological outcomes as compared to male animals.
Dueling dynamics: competition between detachment rupture, splay faults, &amp; off-fault damage
Authors: Biemiller James , Gabriel Alice-Agnes , Ulrich Thomas 
Published: May 2022

Abstract
High-resolution observations show that large earthquakes commonly involve slip on multiple faults along with localized and distributed inelastic off-fault damage. Despite a lack of modern large earthquakes on shallowly dipping detachments, Holocene Mw>7 detachment ruptures are preserved in the paleoseismic record and inferred from historical accounts of such earthquakes and resulting tsunamis. Even in well-recorded megathrust earthquakes, the effects of non-linear off-fault plasticity and dynamically reactivated splay faults on shallow deformation and surface displacements, and thus hazard, remain elusive. Here, we develop geologically, geodetically and geophysically constrained 3D dynamic rupture models of the active Mai’iu fault in Papua New Guinea that highlight how multiple dynamic shallow deformation mechanisms compete in large detachment earthquakes. We show that splay faults in the detachment’s hanging wall are likely to rupture coseismically, with more slip expected on splays that dip at shallow angles synthetic to the detachment. Inelastic off-fault yielding in the hanging wall localizes into subplanar shear bands indicative of newly initiated splay faulting, most prominently above detachments with thick sedimentary basins in their hanging walls. Dynamic splay faulting and sediment failure limit shallow detachment rupture, modulating coseismic subsidence patterns, near-shore slip velocities, and the seismic and tsunami hazards posed by detachment earthquakes.
Heterogeneous scene matching based on gradient direction distribution field
Authors: Li Qingge , Lu Ruitao , Yang Xiaogang , Wang Siyu , Shen Tong , Xia Wenxin , Wei Zhaoying 
Published: May 2022

Abstract
Heterogenous scene matching is one of the key technologies in the field of computer vision. The image rotation problem has been a hot and difficult problem in the field of heterogenous scene matching. In this paper, a heterogenous scene matching method based on the gradient direction distribution field is proposed. The Distributed field theory is introduced into the heterogenous scene matching for the first time. First, the gradient direction distribution field is constructed and fuzzified, and then the effective regions are selected. Then, the concept of main direction distribution field is defined to solve the matching errors due to the existence of rotational transformations between heterogeneous source images. Third, the Chi-square distance is introduced as a similarity measure. At last, the hill-climbing method search strategy is adopted, which greatly improves the efficiency of the algorithm. Experimental results on 8 pairs of infrared and visible heterogenous images demonstrate that the proposed method outperforms the other state-of-the-art region-based matching methods in terms of robustness, accuracy and real-time performance.
Scene Recognition with Objectness, Attribute and Category Learning
Authors: Zhang Ji , Ainam Jean-Paul , Zhao Li-hui , Song Wenai , Wang Xin 
Published: May 2022

Abstract

Scene classification has established itself as a challenging research problem. Compared to images of individual objects, scene images could be much more semantically complex and abstract. Their difference mainly lies in the level of granularity of recognition. Yet, image recognition serves as a key pillar for the good performance of scene recognition as the knowledge attained from object images can be used for accurate recognition of scenes. The existing scene recognition methods only take the category label of the scene into consideration. However, we find that the contextual information that contains detailed local descriptions are also beneficial in allowing the scene recognition model to be more discriminative. In this paper, we aim to improve scene recognition using attribute and category label information encoded in objects. Based on the complementarity of attribute and category labels, we propose a Multi-task Attribute-Scene Recognition (MASR) network which learns a category embedding and at the same time predicts scene attributes. Attribute acquisition and object annotation are tedious and time consuming tasks. We tackle the problem by proposing a partially supervised annotation strategy in which human intervention is significantly reduced. The strategy provides a much more cost-effective solution to real world scenarios, and requires considerably less annotation efforts. Moreover, we re-weight the attribute predictions considering the level of importance indicated by the object detected scores. Using the proposed method, we efficiently annotate attribute labels for four large-scale datasets, and systematically investigate how scene and attribute recognition benefit from each other. The experimental results demonstrate that MASR learns a more discriminative representation and achieves competitive recognition performance compared to the state-of-the-art methods.
Biofilms preserve the transmissibility of a multi-drug resistance plasmid
Authors: Top Eva , Metzger Genevieve , Ridenhour Benjamin , France Michael , Gliniewicz Karol , Millstein Jack , Settles Matthew L. , Forney Larry , Stalder Thibault 
Published: May 2022

Abstract
Self-transmissible multidrug resistance (MDR) plasmids are a major health concern because they can spread antibiotic resistance to pathogens. Even though most pathogens form biofilms, little is known about how MDR plasmids persist and evolve in biofilms. We hypothesize that (i) biofilms act as refugia of MDR plasmids by retaining them in the absence of antibiotics longer than well-mixed planktonic populations, and that (ii) the evolutionary trajectories that account for the improvement of plasmid persistence over time differ between biofilms and planktonic populations. In this study, we evolved Acinetobacter baumannii with an MDR plasmid in biofilm and planktonic populations with and without antibiotic selection. In the absence of selection biofilm populations were better able to maintain the MDR plasmid than planktonic populations. In planktonic populations plasmid persistence improved rapidly but was accompanied by a loss of genes required for the horizonal transfer of plasmids. In contrast, in biofilms most plasmids retained their transfer genes, but on average plasmid persistence improved less over time. Our results showed that biofilms can act as refugia of MDR plasmids and favor the horizontal mode of plasmid transfer, which has important implications for the spread of MDR.
Research on the influencing factors of vaginal cuff dehiscence after Laparoscopic hysterectomy
Authors: Shi Yao , Wang Lan-ying , Han Ke-ping , Wang Qi-qin , Wang Si-yuan , Huang Chun-fang 
Published: May 2022

Abstract
Objective: To explore the influencing factors of vaginal cuff dehiscence after laparoscopic hysterectomy. Methods: From January 2015 to December 2021, the clinical data of patients who had vaginal cuff dehiscence after laparoscopic hysterectomy in our hospital were analyzed retrospectively, univariately, and multivariately Logistic regression was used to analyze the high-risk factors of vaginal cuff dehiscence. Results: Among 1459 cases with laparoscopic hysterectomy, there were 9 cases with vaginal cuff dehiscence after the operation, with an incidence of 0.617%. Univariate logistic regression analysis showed that preoperative hemoglobin value, vaginal cuff suture method, and postoperative first sexual lifetime were related to vaginal cuff dehiscence after laparoscopic hysterectomy (P < 0.05). Preoperative hemoglobin value of <90g/L and time interval between postoperative first sexual life and operation <3months were independent risk factors for vaginal cuff dehiscence after laparoscopic hysterectomy (P < 0.05), according to multivariate logistic regression analysis. Conclusions: Postoperative hemoglobin correction ≥90g/L and the time interval between postoperative first sexual life and operation ≥ 3months can reduce the occurrence of vaginal cuff dehiscence after laparoscopic hysterectomy.
The joint effect of sleep disorders, initiating sleep and exercise frequency on the risk of coronary heart disease in Chinese urban elderly
Authors: Lin Jiujing , Yao Huichen , Li Jia , Hou Chenyang , Song Xia , An Kang , Tian Shoufeng , Li Xiaoliang , Wang Yun , Guo Qing , Liu Weihua , Zhao Hengxia , He Jinjie , Hou Qingzhi 
Published: May 2022

Abstract
Background: Sleep quality and exercise frequency are closely associated with coronary heart disease (CHD). Few studies focused on the joint effect of initiating sleep, sleep disorders and exercise frequency on the risk of CHD in elderly. Based on Boshan Elderly Cohort Study (BSECS), we explored the sleep quality, exercise frequency and their joint effects on the risk of CHD.Methods: We collected 678 participants whose age ≥60 years old from Boshan district hospital. We used Pittsburgh Sleep Quality Index (PSQI) to evaluate the sleep quality, and obtained physical examination information from hospital.Results: Compared with non-CHD group, CHD patients spent more time in initiating sleep (time≥60mins, 34.59% vs 22.93%, P=0.025), and less time in exercising(exercise frequency<1times/week, 23.90% vs 17.15%, P=0.024). In multiple logistic regression analysis, sleep latency ≥ 60 mins were associated with CHD risk (adjusted OR=1.82; 95%CI: 1.16, 2.86; P=0.010). The adjusted OR (95%CI) of CHD was 2.24 (1.16, 4.34) for sleep duration <5 hours vs 5 - 9 hours. Compared with exercise frequency <1 times/week, the adjusted OR for exercise frequency ≥ 1 times/week was 0.66 (95% CI: 0.44, 0.98; P=0.037). In addition, the joint effects of long sleep latency (≥ 60 mins) and sleep disorders were associated with CHD (adjusted OR=3.29; 95%CI: 1.35,7.98; P=0.009), and the joint effect of exercise frequency ≥ 1 times/week and good initiating sleep were also associated with CHD, the adjusted OR (95%CI) was 0.39 (0.20, 0.77).Conclusions: Long sleep latency, high frequency of initiating sleep difficulty, sleep disorders and short sleep duration were positively associated with CHD. In addition, the joint effect of long sleep latency and sleep disorders were positively correlated with CHD incident, however, the joint effect of exercise frequency ≥ 1times/week and good initiating sleep were negatively associated with the risk of CHD.
Effect of local endometrial injury in Follicular vs. luteal phase on implantation and pregnancy outcomes of Frozen Embryo Transfer Cycles in women with repeated in vitro fertilization failure.A randomized clinical trial
Authors: Kashani Ladan , parsaiyan zahra 
Published: May 2022

Abstract
Introduction
:recurrent implantation failure(RIF)refers to failure to achieve a clinical pregnancy after transferring at least four good quality embryos in a minimum of three fresh or frozen cycles.Endometrial scratch is the newly proposed surgical strategy to improve endometrial receptivity;the healing process following scratch may release cytokines and growth factors which encourage endometrial growth and facilitates implantation.Timing of this procedure is a point that may lead to different outcomes.This study compares follicular versus luteal phase injury due to their different molecular patterns on the outcome of embryo transfer in RIF patients.
Study design:
This study is a double blinded randomized clinical trial.Patients came into infertility clinic of Arash women’s hospital in years2017and2018are divided into two groups. In one group injury was done with pipelle at4th-6thday of frozen embryo transferring cycle(n = 38)and in the other one it was done at21th- 23thday of the cycle before the FET (n = 40).Then the infertility rates were compared.
Results
Totally29(41.4%)chemical pregnancies happened,15(51.7%)of them was in follicular group and14(48.3%)in luteal group.28(40%)clinical pregnancies happened totally which were equal in both groups(14 in each one).Ongoing pregnancies happened in 22(31.4%)patients that12(54.5%)of them were in follicular and the other10(45.5%)were in luteal group.
Conclusion
According to this study,local endometrial injury by pipelle didn’t show any significant differences in both groups pregnancy outcomes.But in the follicular group the IVF cycle time period is decreased and therefore the psychological burden of long time required for luteal phase LEI will decrease and is more acceptable for patients,maybe it’s better to do LEI in follicular phase;more studies with larger sample sizes recommended.
Hypoxia induces chemoresistance to proteasome inhibitors through orchestrating deSUMOylation and ubiquitination of SRC-3 in multiple myeloma
Authors: Liu zhiqiang , Guo Jing , Lv Yangyang , Wang Sheng , Peng Ziyi , Xie Ying , Wang Yixuan , Jiang Hongmei , Li Xin , Wang Qimeng , Hu Meilin , Mu Jiangpeng , Wang Jingya , Xie Yangyang , Cheng Xiankui , Zhao Zhigang 
Published: May 2022

Abstract
The bone marrow microenvironment where multiple myeloma (MM) originated is hypoxic and an important stimulus for initiation of drug resistance to chemotherapies, but the underlying mechanisms and key regulators are still indistinct. In the current study, we found that hypoxia stimulus easily induced chemoresistance to proteasome inhibitors (PIs) but not to other chemicals, and the steroid receptor coactivator 3 (SRC-3) expression was remarkably augmented at posttranslational level. Protein interactome analysis identified SENP1 as a key modifier of SRC-3 stability, as deSUMOylation by SENP1 attenuated the K11-linked polyubiquitination of SRC-3. Depletion of SENP1 in MM cells by CRISPR/cas9 sgRNA, or in SENP1fl/flCD19Cre/+ B cells, accelerated the degradation of SRC-3, and overcame the resistance to PIs at vast scale, which phenotype was similar to administration of SENP1inhibitor Momordin Ιc (Mc) in the Vk*Myc and 5TGM1 mouse models and patient derived xenograft (PDX) of myeloma. Importantly, SENP1 level was positively correlated with SRC-3 level in the tissues from refractory/relapsed MM, as well as in xenograft tissues from mice treated with bortezomib and Mc. Taken together, our findings suggest that hypoxia induced SENP1 is a crucial regulator of chemoresistance to PIs, and shed light on developing therapeutic strategies to overcome chemoresistance by using small molecules targeting SENP1 or SRC-3.
Daytime napping and the risk of liver cancer in the context of predictive, preventive, and personalized medicine: a large population-based prospective cohort study
Authors: Arafa Ahmed , Eshak Ehab S. , Shirai Kokoro , Muraki Isao , Tamakoshi Akiko , Iso Hiroyasu 
Published: May 2022

Abstract
Background: Liver cancer is a major cause of morbidity and mortality in Japan and worldwide, that can be prevented by controlling its risk factors. On the other hand, daytime napping is a common behavior, especially among older adults, that was related in previous literature to unfavorable health conditions, including cancer. Thus, investigating whether daytime napping could be associated with liver cancer risk for possible preventive interventions and identifying populations at risk to personalize such interventions are essential. We, therefore, used the framework of predictive, preventive, and personalized medicine to study the association between daytime napping and liver cancer risk among the general population of Japan. Methods: In this prospective cohort study, data of 51,185 participants, aged 40-79 years, and registered in the Japan Collaborative Cohort Study (JACC Study) were analyzed. Incident cases of liver cancer were diagnosed using cancer registries, hospital records, and death certificates. Daytime napping was assessed using the JACC baseline self-administered questionnaire. We used the Cox regression to calculate hazard ratios (HRs) and their 95% confidence intervals (CIs) of incident liver cancer among participants in the age categories of the 40s, 50s, 60s, and 70s who reported daytime napping compared with their counterparts who did not. Results: Within 669,734 person-years of follow-up, 341 participants developed liver cancer. Daytime napping was associated with the increased risk of liver cancer among participants who were in their 60s and 70s of age after adjusting for sex: HRs (95% CIs) 1.88 (1.35, 2.61) and 1.96 (1.18, 3.26), lifestyle and medical history: 1.76 (1.27, 2.47) and 1.82 (1.07, 3.09), and history of liver diseases: 1.66 (1.18, 2.34) and 1.72 (1.01, 2.94), respectively. No associations were detected among participants from the 40s and 50s age groups. The association did not significantly differ between men and women (p- interaction= 0.775). Sensitivity analyses by excluding participants with a positive history of liver disease and those who reported short or long sleep duration did not materially affect the results. Conclusions: Daytime napping was associated with the increased risk of liver cancer among Japanese older adults. For liver cancer risk prevention, older adults should be advised against daytime napping.