bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desfechos clínicos dos idosos hospitalizados com COVID-19
Authors: Paula Aline da Silva , Hammerschmidt Karina Silveira de Almeida , Lenardt Maria Helena , Fugaça Neidamar Pedrini Arias , Souza Alcione Oliveira de , Lachouski Luciane 
Published: January 2022

Estudo quantitativo documental com objetivo de analisar desfechos clínicos e características sociodemográficas e clínicas de idosos hospitalizados pelo Coronavírus (COVID-19). Foi realizada pesquisa documental, com dados do Núcleo de Epidemiologia Hospitalar sobre idosos hospitalizados com COVID-19 em 2020. Os resultados mostram que predominou o sexo masculino (50,3%), a idade média de 71,9, e as multimorbidades (88,8%). No prognóstico, 70,9% receberam alta, 22,9 % óbitos e 6,1% transferência para outros hospitais. Nas altas prevaleceram: idade média de 70,4; sexo masculino 53,3%, uso de suporte de oxigênio (72,44%), em que 5,5% utilizaram ventilação mecânica, foram pronados (79,53%), tiveram média de pressão parcial de Oxigênio (PaO2) de 102,79 ± 47,47, D-Dímero de 2016,98 ± 1994,94, e o exame de tomografia com aspecto em opacidades ocorreu em 66,79%. Nos óbitos predominaram: idade média de 76,6, sexo feminino (58,5%), necessidade de oxigenoterapia em 97,53% dos idosos, uso de ventilador mecânico (VM) 58,54% e posição de prona em 60,98%, média D-Dímero de 5022,29, exame de tomografia com aspecto em opacidades em 73,2%. Por fim, nos desfechos alta e óbito, as morbidades prevalentes foram: HAS, diabetes Mellitus e doença cardiovascular. A idade média foi de 70,4 (alta) e 76,6 (óbito). Principal alteração na tomografia foi opacidades em vidros fosco (73,2%), 97,53% utilizaram oxigênio, e 58,54% necessitaram de intubação.
Kadar Albumin Ikan Glodok Segar Boleophthalmus boddarti dengan Metode Biuret
Authors: Belqis Farah Nabila , Santosa Hari , Syauqi Ahmad 
Published: January 2022

one of which is mudskipper. The species Boleophthalmus boddarti is able to survive outside the water for long periods, spending time outside the surface of the water walking, wallowing in mud, and entering burrows it creates. The purpose of this study was to analyze the albumin levels in fresh mudskipper meat of Boleophthalmus boddarti species using the biuret method. The research method is descriptive and is repeated three times. Using the biuret method with the spectrophotometer technique the standard curve equation y = 0.0482x + 0.0036. The highest albumin yield was found in the head meat, weighing 0.085 g with the absorbance in the spectrophotometer was 92.80 nm. Compared with the tail meat, the weight of albumin is 0.080 g and the absorbance is 70.08 nm. The greater the absorbance effect on albumin levels, the average measurement of albumin content of mudskipper species Boleophthalmus boddarti, the highest was found in the head meat, namely 93.667% and the albumin content in the meat of the tail was lower, namely 65.97%.Keywords: Albumin, Protein, Boleophthalmus boddarti ABSTRAK Albumin merupakan komponen protein dalam plasma yang dapat larut dalam air. Albumin dapat di jumpai dalam sebagian besar protein dalam ikan, salah satunya yaitu ikan glodok. Spesies Boleophthalmus boddarti mampu bertahan hidup di luar perairan dalam waktu yang lama, menghabiskan waktunya di luar permukaan air dengan berjalan, berkubang di lumpur, dan memasuki liang yang dibuatnya. Tujuan dari penelitian ini adalah untuk menganalisa kadar albumin pada daging ikan glodok segar spesies Boleophthalmus boddarti dengan metode biuret. Metode penelitian adalah deskriptif dan pengulangan tiga kali. Menggunakan metode biuret dengan teknik spektrofotometer persamaan kurva standart y = 0,0482x + 0,0036. Hasil albumin tertinggi di dapatkan pada bagian daging kepala yaitu seberat 0,085 gr dengan absorbansi dalam spektofotometer adalah 92,80 nm. Dibandingkan dengan bagian daging ekornya berat albumin yang di dapatkan seberat 0,080 gr dan absorbansi 70,08 nm. Semakin besar absorbansi berpengaruh terhadap kadar albumin, rata – rata pengukuran kadar albumin ikan glodok spesies Boleophthalmus boddarti paling tinggi terdapat pada daging bagian kepala yaitu 93,667 % dan kadar albumin pada daging bagian ekornya lebih rendah yaitu 65,97 %. Kata kunci : Albumin, Protein, Boleophthalmus boddarti
DEVELOPMENT OF RESEARCH OF CHEMISTRY OF COORDINATION COMPOUNDS IN V.I. VERNADSKY INSTITUTE OF GENERAL AND INORGANIC CHEMISTRY NAS OF UKRAINE: FROM THE 30'S TWENTIETH CENTURY (part 2)
Authors: Koval Larisa , Trunova Elena , Pekhnyo Vasyl 
Published: January 2022

The review considers the main stages of development of the chemistry of coordination compounds at the Institute of General and Inorganic Chemistry. VI Vernadsky National Academy of Sciences of Ukraine on the occasion of the 90th anniversary of its founding. An overview of complex compounds of p, d, f-me­tals with different classes of ligands (inorganic and organic), features of their synthesis, study of the structure and properties of the obtained compounds, contains current material on the use of synthesized complexes to create functional materials for different purposes. Me­thods of synthesis have been developed, do­zens of new coordination compounds with derivatives of hydrazones, amines, azomethanes, and thiosemicarbazones have been synthesized and isolated in the individual state. Their composition, structure and physicochemical pro­perties are determined. The general regularities that take place in the process of comp­lexation of metals with ligands, as well as factors influencing the composition, structure and physico­chemical properties of the obtained coordination compounds are established.
For the long history of the Institute has accumulated a huge amount of material on the problems of modern coordination chemistry. Significant research in this area belongs to Ukrainian scientists who have worked long and fruitfully at the Institute: A.K. Babko, К.B. Yat­si­mirsky, Ya.A. Fialkov, I.A. Sheka, S.V. Volkov, N.A. Kostromina, and who created scientific schools, known not only in Ukraine but also abroad. To date, the attention of scientists of the Institute has shifted from classical monomeric to bigeteronuclear, polynuclear, multiligand complexes, which is primarily due to intensive research of new functional materials: optical and magnetic, biologically active substances, as well as effective adsorbents, che­mical sensors, catalysts, catalysts, catalysts and biochemical processes.
Modeling of Overpressure Generation–Evolution of the Paleogene Source Rock and Implications for the Linnan Sag, Eastern China
Authors: Li Chao , Zhang Likuan , Luo Xiaorong , Wang Bing , Lei Yuhong , Cheng Ming , Luo Hongmei , Wang Changjiang , Yu Lan 
Published: January 2022

Subsurface pore pressure affects the direction of hydrocarbon migration, determines the distribution of the hydrocarbon reservoir, and provides scientific reference for drilling planning. Overpressures are widespread in the Paleogene Shahejie Formation in the Linnan Sag, which is closely related to the distribution of oil reservoir. However, the overpressure generation mechanisms are undefined, let alone the relationship between the evolution of paleo-overpressure and hydrocarbon migration in the Linnan Sag, which brings great challenges for the understanding of oil accumulation and future oil exploration. Basin modeling was carried out to solve the issue of quantitative evaluation of overpressure mechanisms and to restore the overpressure evolution of the Paleogene source rocks. The implications for the pore pressure prediction and oil migration in the Linnan Sag were further discussed. The modeling results show that the disequilibrium compaction of mudstones is a dominated overpressure mechanism of source rocks in the Linnan Sag, which accounts for approximately 90% of the measured overpressure in the region. The remainder part of overpressure was generated by hydrocarbon generation; however, the effects of hydrocarbon generation on overpressure evolution were limited in the intervals deeper than 4000 m. The significance of the overpressure mechanism is that the porosity-dependent method will give a satisfactory pressure prediction result in the current exploration depth range (3800–4300 m). The overpressure evolution of the source rock has undergone a cycle of “accumulation-dissipation-reaccumulation,” which corresponds to the age of 45.5–24.0 Ma (Es3-Ed period), 24.6–14.0 Ma (Ed period), and 14.0–0 Ma (Ng-Qp period). The oil potential of the Es3l shows good inheritance with the overpressure in the source rock, indicating overpressure increased the driving force for oil migration. The oil released from the source rock has a trend to migration from the center of the sag to the uplift belt, which is also indicated by the physical properties of crude oil. The knowledge of the generation and evolution of overpressure has great significance for further exploration in the Linnan Sag and other extensional basins.
Clinical and Neonatal Outcomes of Children Born After ICSI With or Without Surgically Acquired Sperm: A Retrospective Cohort Study
Authors: Du Mingze , Zhang Junwei , Li Zhen , Liu Yang , Wang Kexin , Guan Yichun 
Published: January 2022

ObjectiveThe purpose of this study was to explore the effects of different methods of obtaining sperm for intracytoplasmic sperm injection (ICSI) cycles on the live birth rate (LBR) and neonatal outcomes.MethodsThis was a single-center retrospective cohort study conducted from January 2016 to December 2019. A total of 3557 ICSI cycles were included in the analysis, including 540 cycles in the surgically acquired sperm group and 3017 cycles in the ejaculated sperm group. The main outcome measure was the LBR.ResultsThe clinical pregnancy rate in the surgically acquired sperm group was 69.4%, which was significantly higher than the 59.7% clinical pregnancy rate in the ejaculated sperm group (P=0.01). The LBR of the surgically acquired sperm group was significantly higher than that of the ejaculated sperm group (63.1% vs. 51.2%, P&lt;0.01). Similarly, the singleton LBR was also higher in the surgically acquired sperm group than in the ejaculated sperm group (45.4% vs. 39.2%, P=0.04). Due to differences in the baseline characteristics of the two groups, multiple logistic regression analysis was performed. After multiple logistic regression analysis, the different methods of obtaining sperm were independent risk factors influencing the clinical pregnancy rate (adjusted odds ratio (AOR)=0.73, 95% confidence (CI)=0.56-0.95, P=0.02) and LBR (AOR=0.69, 95% CI=0.54-0.89, P=0.01). The preterm birth rate (AOR=1.42, 95% CI=0.62-3.25, P=0.41) and the incidence of low birth weight (AOR=1.03, 95% CI=0.45-2.34, P=0.95), small for gestational age (AOR=0.81, 95% CI=0.39-1.68, P=0.57), macrosomia (AOR=0.88, 95% CI=0.47-1.66, P=0.70) and large for gestational age (AOR=1.08, 95% CI=0.65-1.82, P=0.76) were not affected by the different methods.ConclusionThe clinical pregnancy rate and LBR of the surgically acquired sperm group were higher than those of the ejaculated sperm group. There was no significant difference between the neonatal outcomes of the two groups.
Angiopoietin-Like Protein 8/Leptin Crosstalk Influences Cardiac Mass in Youths With Cardiometabolic Risk: The BCAMS Study
Authors: Wang Dongmei , Feng Dan , Wang Yuhan , Dong Peiyu , Wang Yonghui , Zhong Ling , Li Bo , Fu Junling , Xiao Xinhua , Speakman John R. , Li Ming , Gao Shan 
Published: January 2022

ObjectivesThe link between excess adiposity and left ventricular hypertrophy is multifaceted with sparse data among youths. Given that adipokines/hepatokines may influence lipid metabolism in myocardium, we aimed to investigate the relation of the novel hepatokine angiopoietin-like protein 8 (ANGPTL8) and other adipokines with cardiac structure in a cohort of youths and explore to what extent these adipokines/hepatokines affect cardiac structure through lipids.MethodsA total of 551 participants (aged 15-28 years) from the Beijing Child and Adolescent Metabolic Syndrome Study (BCAMS) cohort underwent echocardiographic measurements plus a blood draw assayed for five adipokines/hepatokines including adiponectin, leptin, retinol binding protein 4, fibroblast growth protein 21 and ANGPTL8.ResultsBoth ANGPTL8 (β = -0.68 g/m2.7 per z-score, P= 0.015) and leptin (β = -1.04 g/m2.7 per z-score, P= 0.036) were significantly inversely associated with left ventricular mass index (LVMI) independent of classical risk factors. Total cholesterol and low-density lipoprotein cholesterol significantly mediated the ANGPTL8–LVMI association (proportion: 19.0% and 17.1%, respectively), while the mediation effect of triglyceride on the ANGPTL8–LVMI relationship was strongly moderated by leptin levels, significantly accounting for 20% of the total effect among participants with higher leptin levels. Other adipokines/hepatokines showed no significant association with LVMI after adjustment for body mass index.ConclusionsOur findings suggest ANGPTL8, particularly interacting with leptin, might have a protective role in cardiac remodeling among youths with risk for metabolic syndrome. Our results offer insights into the pathogenesis of the cardiomyopathy and the potential importance of tissue-tissue crosstalk in these effects.
Features of Lymph Node Metastasis and Structural Recurrence in Papillary Thyroid Carcinoma Located in the Upper Portion of the Thyroid: A Retrospective Cohort Study
Authors: Heng Yu , Feng Siqi , Yang Zheyu , Cai Wei , Qiu Weihua , Tao Lei 
Published: January 2022

BackgroundThis study aims to reveal the features of lymph node metastasis (LNM) and recurrence in papillary thyroid carcinoma (PTC) tumors located in the upper portion of the thyroid.MethodsA total of 1075 PTC patients were retrospectively reviewed, including 314 patients with a tumor in the upper portion of the thyroid. Another 103 PTC patients with upper portion diagonsis from three clinical centers were included for external validation.ResultsThe results showed no difference between the patients with a tumor in the upper portion of the thyroid and those with a tumor in the non-upper portion in terms of overall LNM rates. However, patients with a tumor in the upper portion were significantly more prone to LLNM and exhibited a significantly worse recurrence outcome than those with a tumor in other subregions. Multivariate analysis showed that four factors—age no more than 40, maximum tumor diameter no less than1.0 cm, the presence of thyroid capsular invasion, and tumor with ipsilateral nodular goiter—were independent risk factors for LLNM of the tumor in the upper thyroid. A predictive risk-scoring model was established based on these factors.ConclusionsPatients with PTC located in the upper portion may have an exclusive lymphatic drainage pathway to the lateral neck region and are more prone to suffer from LLNM and tumor recurrence than those with a tumor located in other subregions. A new postoperative strategy selection flow chart was established based on our newly created risk-scoring model that can effectively predict the individualized possibility of LLNM for PTC patients with a tumor in the upper portion.
Highly Efficient MoS2/CsxWO3 Nanocomposite Hydrogen Gas Sensors
Authors: Wu Chang-Mou , Shrisha  , Motora Kebena Gebeyehu , Chen Guan-Ying , Kuo Dong-Hau , Gultom Noto Susanto 
Published: January 2022

Hydrogen gas sensors are important because of the significant use of hydrogen in industrial and commercial applications. In this study, we synthesized a novel CsxWO3/MoS2 nanocomposite using a solvothermal method. The samples were spin-coated on Si/SiO2 substrates, and the sensors were fabricated with interdigital electrodes. The hydrogen gas sensing properties of the sensor were investigated. CsxWO3/MoS2 exhibited an outstanding hydrogen gas sensing ability at room temperature. In particular, the nanocomposite comprising 15 wt.% MoS2 (15% CsxWO3/MoS2) showed a 51% response to hydrogen gas at room temperature. Further, it exhibited an excellent cyclic stability for hydrogen gas sensing, which is crucial for practical applications. Therefore, this study facilitates the development of effective and efficient hydrogen gas sensors operable at room temperature.
The Association of Body Mass Index With the Risk of Pulmonary Hypertension in Adults: A Systematic Review and Meta-Analysis of Observational Studies
Authors: Pu Shoufang , Yin Lidan , Wen Bi , He Juan 
Published: January 2022

BackgroundsFindings regarding the association of body mass index (BMI) with pulmonary hypertension (PH) are conflicting, and there is no systematic review and meta-analysis to summarize the results. Therefore, the purpose of this systematic review and meta-analysis is to assess this relationship.MethodsTo detect the relevant articles, PubMed, Scopus, and Google Scholar were searched until February 2021. Included essays were pooled using a random-effect model. Cochrane Q-test and I2-test was applied to assess between-study heterogeneity.ResultsFourteen articles (eight cross-sectional and four cohort studies) were included in the meta-analysis. The meta-analysis of comparing highest vs. lowest BMI categories did not indicate a significant association between BMI and PH (Summary Effect Estimate: 1.59 (95% CI: 0.50, 5.07, I2 = 92.3). Furthermore, The summary risk estimate for a one-unit increment in BMI was 1.01 (95 % CI: 0.99, 1.03), with high heterogeneity, I2 = 73.5 %, P heterogeneity &lt;0.001). Subgroup analysis showed significant positive association between BMI and the risk of PH in studies controlled for cofounders, and studies with higher sample sizes (≥2,000).ConclusionThere is no significant association between BMI and risk of pulmonary hypertension. Further studies are required to confirm these findings.
Association Between Non-obstructive Chronic Bronchitis and Incident Chronic Obstructive Pulmonary Disease and All-Cause Mortality: A Systematic Review and Meta-Analysis
Authors: Wu Fan , Fan Huanhuan , Liu Jing , Li Haiqing , Zeng Weifeng , Zheng Silan , Tian Heshen , Deng Zhishan , Zheng Youlan , Zhao Ningning , Hu Guoping , Zhou Yumin , Ran Pixin 
Published: January 2022

BackgroundChronic bronchitis in patients with chronic obstructive pulmonary disease (COPD) is associated with poor respiratory health outcomes. However, controversy exists around whether non-obstructive chronic bronchitis (NOCB) is associated with airflow obstruction, lung function decline, and all-cause mortality in ever smoker or never smoker.Research QuestionThis systematic review and meta-analysis aimed to clarify the relationship between NOCB and incident COPD, lung function decline, and all-cause mortality, and to quantify the magnitude of these associations.Study Design and MethodsWe searched PubMed, Embase, and Web of Science for studies published up to October 1, 2021. Eligibility screening, data extraction, and quality assessment of the retrieved articles were conducted independently by two reviewers. Studies were included if they were original articles comparing incident COPD, lung function decline, and all-cause mortality in normal spirometry with and without chronic bronchitis. The primary outcomes were incident COPD and all-cause mortality. The secondary outcomes were respiratory disease-related mortality and lung function decline. Pooled effect sizes and 95% confidence intervals (CIs) were calculated using the random-effects model.ResultsWe identified 17,323 related references and included 14 articles. Compared with individuals without NOCB, individuals with NOCB had an increased risk of incident COPD (odds ratio: 1.98, 95% CI: 1.21–3.22, I2 = 76.3% and relative risk: 1.44, 95%CI: 1.13–1.85, I2 = 56.1%), all-cause mortality (hazard ratio [HR]: 1.38, 95%CI: 1.26–1.51, I2 = 29.4%), and respiratory disease-related mortality (HR: 1.88, 95%CI: 1.37–2.59, I2 = 0.0%). Data on the decline in lung function could not be quantitatively synthesized, but the five articles that assessed the rate of decline in lung function showed that lung function declines faster in individuals with NOCB. The mean difference in the additional decline in forced expiratory volume in 1 s ranged from 3.6 to 23.2 mL/year.InterpretationIndividuals with NOCB are at a higher risk of incident COPD and all-cause mortality than individuals without NOCB, highlighting the crucial need for strategies to screen for and reduce NOCB risk.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/ PROSPERO, identifier CRD42020202837
Comparison of Efficacy of Anti-interleukin-17 in the Treatment of Psoriasis Between Caucasians and Asians: A Systematic Review and Meta-Analysis
Authors: Zhang Danyi , Qiu Jianing , Liao Xing , Xiao Yi , Shen Minxue , Deng Yaxiong , Jing Danrong 
Published: January 2022

BackgroundInterleukin-17 (IL-17) monoclonal antibody drugs have been increasingly significant in the treatment of psoriasis, but it is not clear whether the efficacy is equivalent across ethnicities.ObjectiveTo explore the differences of short-term efficacy of IL-17 inhibitors between Caucasians and Asians.MethodsThe pooled log risk ratio (logRR) between the groups was estimated. The meta-regression analysis on the logRR was performed, with the proportion of Caucasian patients as the covariate. The subgroup analysis was performed by specific IL-17 inhibitors.ResultsOf the 1,569 potentially relevant studies, sixteen randomized controlled trials (RCTs) were included. For the Psoriasis Area and Severity Index 75 (PASI 75) response at week 12, the pooled logRR of the Asian group and the Caucasian group was 2.81 (95% CI: 2.27–3.35, p &lt; 0.001) and 2.93 (95% CI: 2.71–3.16, p &lt; 0.001), respectively, indicating no significant difference of efficacy between Asians and Caucasians. The meta-regression analysis did not show an association of the proportion of Caucasians with the effect size (β = 0.3203, p = 0.334). In the subgroup analysis, the comparison results of secukinumab were consistent with the main analysis.LimitationsOnly the short-term efficacy was explored. The data from Asian countries were limited.ConclusionsThe short-term efficacy of IL-17 inhibitors in the treatment of psoriasis has no significant difference between Caucasians and Asians.Systematic Review RegistrationPROSPERO, identifier CRD42020201994, https://www.crd.york.ac.uk/prospero/.
Prognostic Value of Ki-67 Index in Patients With Endometrial Stromal Sarcoma
Authors: Meng Yu , Quan Quan , Zhang Fenfen , Liu Yao , Ren Siling , Mu Xiaoling 
Published: January 2022

ObjectiveThe Ki-67 index is used to evaluate cell proliferation activity, which is related to tumor progression, metastasis, and prognosis. We aimed to explore the prognostic value of Ki-67 index in endometrial stromal sarcoma and to explore the optimal cut-off value of Ki-67 index for predicting recurrent endometrial stromal sarcoma.MethodsA total of 82 patients with endometrial stromal sarcoma who were treated in our hospital were collected. Clinicopathological data of these patients were retrospectively analyzed. Ki-67 index was detected by the immunohistochemical method. Receiver operating characteristic curve and the Youden index were performed to determine the optimal cut-off value of Ki-67 index for predicting recurrent endometrial stromal sarcoma. The Cox regression was performed to analyze risk factors affecting prognosis of endometrial stromal sarcoma. The Kaplan–Meier method and Log-rank test were performed to analyze the survival of patients.ResultsThe optimal cut-off value of Ki-67 index for predicting recurrent endometrial stromal sarcoma was 35%. The results of univariate analysis showed that high Ki-67 index (≥35%) was statistically significantly bound up with shorter progress free survival and overall survival. The results of multivariate analysis showed that Ki-67 index (P = 0.001) and ovarian preservation (P = 0.040) were independent prognostic factors of progress free survival.ConclusionsA Ki-67 index cut-off of 35% was optimal for predicting recurrent endometrial stromal sarcoma. Ki-67 index may be a useful prognostic marker in endometrial stromal sarcoma.