bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Serum Interleukin-17 and Interleukin-23 Levels with
Disease Activity, Function, Mobility, Enthesitis Index in Patients with
Ankylosing Spondylitis
Authors: Beyazal Münevver Serdaroğlu , Tayfun Aliekber , Devrimsel Gul , Yıldırım Murat , Arpa Medeni 
Published: November 2022

AbstractAim: More and more studies have demonstrated that the interleukin
(IL)-23/IL-17 axis is highly associated with immune dysfunction and
activated autoimmune inflammation. The purposes of this study were to determine
the serum levels of IL-17 and IL-23 in ankylosing spondylitis (AS) patients
compared with healthy controls and evaluate these cytokine levels based on
disease-related characteristics. Material and Methods: Eighty-six consecutive AS
patients and 70 sex and age-matched healthy controls were included in the study.
The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Ankylosing
Spondylitis Disease Activity Score (ASDAS)-erythrocyte sedimentation rate (ESR),
ASDAS-C reactive protein, the Bath Ankylosing Spondylitis Functional Index
(BASFI), the Spondyloarthritis Research Consortium of Canada (SPARCC) enthesitis
index, the Bath Ankylosing Spondylitis Metrology Index (BASMI), the Ankylosing
Spondylitis Quality of Life Questionnaire (ASQoL) and Achilles pain VAS scores
were recorded. Serum IL-17 and IL-23 levels were examined by enzyme-linked
immunosorbent assay. Results: The serum levels of IL-17, IL-23 and CRP as well
as ESR values were significantly increased in AS patients compared with controls
(1.94 vs. 0.28 pg/mL p ˂ 0.001; 82.9 vs.
44.3 pg/mL p ˂ 0.001; 0.48 vs.
0.30 mg/dL, p=0.001; 12±13.9 vs.
8±6.8 mm/h, p=0.003, respectively). In AS
patients, serum IL-17 levels were significantly correlated with the ASDAS-ESR
and ASDAS-CRP (r=0.244, p=0.024; r=0.258,
p=0.017), but not with ESR, CRP, BASDAI, function, mobility, quality of
life, enthesitis index or Achilles pain scores (all p>0.05). Serum IL-23
levels demonstrated a significant correlation with Achilles pain VAS, but not
with other disease-related parameters (all p>0.05). Conclusions: AS
patients had increased serum IL-17 and IL-23 levels compared with healthy
controls, and serum IL-17 levels were associated with disease activity. Our
study results support the hypothesis that the IL17/23 pathway plays an
important role in the pathogenesis of AS.
Eosinophilic esophagitis: Comparison of clinical, endoscopic and histological scoring systems
Authors: Lorenz Nikolas Johannes , Link Alexander , Czapiewski Piotr , Arnim Ulrike von 
Published: November 2022

Abstract
Background Eosinophilic Esophagitis (EoE) has received increasing attention as a disease entity, and it is now recognized as an important disorder of the Upper Gastrointestinal Tract. Topical corticosteroids (tCS) are effective in clinical-pathological remission induction (RI) and remission maintenance (RM) of active EoE. With scoring systems, such as clinical (SDI), endoscopic (EREFS), and histological (EoEHSS) systems, EoE can be graded, and its disease activity can be assessed.
Objective To discover how closely results within each of the three scoring systems SDI, EREFS, and EoEHSS are correlated between initial diagnosis (ID), RI, and RM, and to determine how well scores from the three systems are intercorrelated at each time point.
Methods Retrospective cohort analysis of patients with active EoE was performed between 2006 and 2020, with follow-up for up to 6 years. SDI, EREFS and EoEHSS scores were recorded at ID, at RI, and in RM. Evaluation employed descriptive statistics, the Friedman test, and Bonferroni-corrected post hoc pairwise comparisons.
Results At RI 29 and at RM 19 EoE patients provided data. Significant correlations were found between EREFS and EoEHSS at RI and in RM. Pairwise comparisons showed significant differences between ID and RI for SDI, for EREFS, and for EoEHSS.
Conclusion The scoring systems tested did not show intercorrelation at ID. Comparison revealed significant differences for SDI, EREFS, and EoEHSS between the systems at ID und RI, but not in RM, during tCS treatment. These results underline the efficacy of tCS (at RI and RM) in the treatment of active EoE.
Implementierbarkeit, Praktikabilität und Akzeptanz ambulanter
Psychotherapie für zuhause lebende ältere Menschen mit
Depression und Pflegebedarf – Ergebnisse des Innovationsfondsprojekts
PSY-CARE
Authors: Tegeler Christina , Hoppmann Fee , Demmerle Christina , Gellert Paul , Ludwig Valentina , Kessler Eva-Marie 
Published: November 2022

Zusammenfassung
Ziel Zuhause lebende pflegebedürftige ältere Menschen mit
Depression sind psychotherapeutisch massiv unterversorgt. Untersucht wird die
Realisierbarkeit ambulanter Psychotherapie bei der Patientengruppe unter den
Bedingungen der Regelversorgung.
Methode Das Innovationsfonds-Projekt PSY-CARE ist eine in Berlin
angesiedelte pragmatische, randomisiert-kontrollierte Studie zur Untersuchung
von Kurzzeit-Verhaltenstherapie für zuhause lebende Menschen
über 60 Jahren mit Pflegegrad und Depression. Ausgewertet werden
Implementierbarkeit, Praktikabilität und Patientenzufriedenheit.
Ergebnisse Allen 102 in die Interventionsgruppe aufgenommenen Patienten
konnte Psychotherapie vermittelt werden, wovon fast alle Therapien
(92,3%) nur durch Hausbesuche realisierbar waren. Die Patienten waren
überwiegend (83,7%) weitgehend bis sehr zufrieden mit der
Psychotherapie. Die für das Projekt gewonnenen ambulanten
Psychotherapeuten bewerteten Angehörigeneinbezug und interprofessionelle
Zusammenarbeit als hilfreich. Anpassungen des Ausbildungs- und
Vergütungssystems wurden als notwendig erachtet.
Schlussfolgerung Hausbesuche, interprofessioneller Austausch und Arbeit
mit Angehörigen müssen reguläre Elemente ambulanter
Psychotherapie werden. Es bedarf einer speziellen gerontopsychologischen
Qualifikation für Psychotherapeuten.
London Dispersion-Assisted Low-Temperature Gas Phase Synthesis of Hydrogen Bond-Inserted Complexes
Authors: Suhm Martin A. , Lange Manuel , Sennert Elisabeth 
Published: November 2022

AbstractSupersonic expansions of organic molecules in helium carrier gas mixtures are used to synthesize model (pre)reactive complexes at low temperature. Whether or not barriers for hydrogen bond rearrangements can be overcome in this collisional process is not well understood. Using the example of alcohols inserting into intramolecular hydrogen bonds of α-hydroxy esters, we explore whether dispersion energy donors can assist the process in a systematic way. Bromo, iodo, and tert-butyl substitution of benzyl alcohol in the para-position is used to show that the insertion process into methyl glycolate is controllable, whereas it is largely avoided for the chiral methyl lactate homologue. Methyl lactate appears to steer the transient chirality of benzyl alcohol derivatives in a uniform direction relative to the lactate handedness for the OH∙∙∙O=C insertion product, as well as for the competing attachment to the hydroxy group of the ester. A simple rule based on the total binding energy in relation to the rearrangement barrier is tentatively proposed to estimate whether the insertion is feasible or not in such molecular complexes during expansion.
Aminium-Radical-Mediated Intermolecular Hydroamination of Nonactivated Olefins
Authors: Wang Fei , Jia Si-Ming , Huang Yi-Hang 
Published: November 2022

AbstractAminium radicals are attractive intermediates in synthetic chemistry that readily participate in a series of C–N bond-forming processes. Here, we briefly discuss strategies for generating aminium radicals from various precursors in the context of intermolecular alkene amination, and we highlight recent advances in aminium-radical-mediated hydroaminations of nonactivated olefins to directly approach alkylamines.1	Introduction2	Intermolecular Hydroamination of Nonactivated Alkenes with Alkylamines under Photoredox Catalysis3	Intermolecular Hydroamination of Nonactivated Alkenes with Aliphatic Azides4	Conclusions
Oligodendrocyte precursor cells ingest axons in the mouse neocortex
Authors: Buchanan JoAnn , Elabbady Leila , Collman Forrest , Jorstad Nikolas L. , Bakken Trygve E. , Ott Carolyn , Glatzer Jenna , Bleckert Adam A. , Bodor Agnes L. , Brittain Derrick , Bumbarger Daniel J. , Mahalingam Gayathri , Seshamani Sharmishtaa , Schneider-Mizell Casey , Takeno Marc M. , Torres Russel , Yin Wenjing , Hodge Rebecca D. , Castro Manuel , Dorkenwald Sven , Ih Dodam , Jordan Chris S. , Kemnitz Nico , Lee Kisuk , Lu Ran , Macrina Thomas , Mu Shang , Popovych Sergiy , Silversmith William M. , Tartavull Ignacio , Turner Nicholas L. , Wilson Alyssa M. , Wong William , Wu Jingpeng , Zlateski Aleksandar , Zung Jonathan , Lippincott-Schwartz Jennifer , Lein Ed S. , Seung H. Sebastian , Bergles Dwight E. , Reid R. Clay , da Costa Nuno Maçarico 
Published: November 2022

Neurons in the developing brain undergo extensive structural refinement as nascent circuits adopt their mature form. This physical transformation of neurons is facilitated by the engulfment and degradation of axonal branches and synapses by surrounding glial cells, including microglia and astrocytes. However, the small size of phagocytic organelles and the complex, highly ramified morphology of glia have made it difficult to define the contribution of these and other glial cell types to this crucial process. Here, we used large-scale, serial section transmission electron microscopy (TEM) with computational volume segmentation to reconstruct the complete 3D morphologies of distinct glial types in the mouse visual cortex, providing unprecedented resolution of their morphology and composition. Unexpectedly, we discovered that the fine processes of oligodendrocyte precursor cells (OPCs), a population of abundant, highly dynamic glial progenitors, frequently surrounded small branches of axons. Numerous phagosomes and phagolysosomes (PLs) containing fragments of axons and vesicular structures were present inside their processes, suggesting that OPCs engage in axon pruning. Single-nucleus RNA sequencing from the developing mouse cortex revealed that OPCs express key phagocytic genes at this stage, as well as neuronal transcripts, consistent with active axon engulfment. Although microglia are thought to be responsible for the majority of synaptic pruning and structural refinement, PLs were ten times more abundant in OPCs than in microglia at this stage, and these structures were markedly less abundant in newly generated oligodendrocytes, suggesting that OPCs contribute substantially to the refinement of neuronal circuits during cortical development.
Conceptual blending in entrenched Persian noun-noun nominal compounds
Authors: Diyanati Masoumeh , Rezaei Hadaegh , Rafiei Adel 
Published: November 2022

Abstract
The current paper offers an analysis of a set of 27 entrenched endocentric, exocentric, and copulative
āb (water)-noun nominal compounds in Persian with both right- and left-headed compounds, based on the network
model of conceptual blending theory. Given that an emergent meaning is involved in endocentric and copulative compounds, the same
as in exocentric compounds, the paper argues that all types of compounds can be insightfully defined as conceptual blends.
However, the conceptual blending network model fails to show the distinct role of head and modifier in the overall meaning of
compounds, on the one hand, and the qualifying difference in the extent of emergent meaning among various types of compound words,
on the other hand. Our study also lends support to a correspondence between the continuum of integration networks and the
continuum of figurativity in compounds.
Conceptual metaphor sport as war in Vietnamese football news
Authors: Hanh Nguyen Thi Bich , Huong Le Vien Lan , Hien Pham 
Published: November 2022

Abstract
Stemming from the widespread appearance of war metaphors in Vietnamese sports news, the article conducts the
research on the emergence of metaphors related to the source domain of war in Vietnamese sports news. The International
Commentary section aims to clarify the relationship between “sport” and “war” in Vietnamese mind maps. This article analyses the
conceptual metaphor sport as war underlying the metaphorically used words and expressions in Vietnamese sports news and
explains the mapping scheme between source domain and target domain. Based on the experiential correlations and knowledge mapped
from source domain to target domain, the article shows typical thinking of the conceptual construction, which is both universal
and typical of Vietnamese people thinking, indicating the hierarchy in conceptual thinking. The primary metaphor sport as
war, through mapping scheme, the article proves the appearance of derivative metaphors in sports news such as sports
competition as a battle between the warring parties; the footballers as military participants; the main footballers in
competition are the weapons in the war; tactics in competing in a sports event as tactics in battle; the actions of
footballers are the actions of the warring parties; fouls and misconduct are destroying an opponent in battle; coach as battle
commander; winning/losing the match as winning/losing the battle. The current study’s findings are the metaphors grouped
into categories: battle activities, battle devices, battle results/consequences, battle tactics. The article’s research results
may help journalism students in writing skills and use conceptual metaphors in writing news and articles; suggest to sports
bulletin editors how to use conceptual metaphors in news and articles to increase attraction for readers and listeners; and make
matches more excited, dramatic and attractive.
Divine and human agency in figurative language from John’s Gospel and Jodo‑Shinshu Buddhism
Authors: Richardson Peter , Nagashima Miori 
Published: November 2022

Abstract
This paper seeks to extend the focus of previous analyses of agency and metaphor in Christianity and Buddhism
(Charteris-Black 2017; Chilton 2004;
Richardson 2012; Richardson & Nagashima
2018) by comparing the results of a previous cognitive linguistic analysis of John 14:6 (Kövecses 2011) with an analysis of figurative language and agency patterns in an extract from a Jodo
Shinshu Buddhist text (Wilson 2009). The comparative analysis highlights both locally
contingent and more stable differences in both texts. However, we also discuss some highly schematic conceptual similarities that
deserve further study. These include some similarities in their use of journey and light source domains, the
role of the divine agent in the salvation process, one aspect of the divine entity embodying and acting as instrument for another
aspect of the same divine entity, and the divine act being a paragon for human action.
Neology pathways
Authors: Ferrucci Francesca 
Published: November 2022

Abstract
A quantitative analysis of the Italian lexicon has been made, focusing on the semantic relationships of
meronymy/holonymy and hyponymy/hypernymy. The study used two lexicographical sources, together representing one of the largest
structured Italian datasets. Within the theoretical debate on the ontolex interface, the aforementioned semantic
relationships can be particularly interesting, assuming their closeness to crucial aspects of cognition. In this framework, the
collected evidence legitimates some hypotheses on the pathways that underlie lexical and semantic neology: the direction from
holonym to meronym(s) appears more productive than the opposite, suggesting that the conceptualization of an object as a whole is
more likely to stimulate further conceptualization of parts, members or substance. The same top-down direction from species to
genus (genera), prevails in hypernyms/hyponyms. Recurring trends of use rates, first attestation dates, and correlation rates can
be exploited further to discuss the issue of cognitive economy and the ways in which it manifests itself in language.
Applying cognitive linguistics to foreign language teaching and learning
Authors: Wirag Andreas , Li Yunong , Zhang Bin 
Published: November 2022

AbstractThe discipline of Applied Cognitive Linguistics is a recent, still emerging framework, which is situated at the interface of Cognitive Linguistics (CL) and Applied Linguistics research (Pütz, Niemeier & Dirven 2001a,2001b). At its core, Applied CL is concerned with the use of CL models, theories, or concepts for L2 teaching and learning, where it aims to create effective teaching methods, activities, or materials. Owing to its more recent origin in the 1990s/2000s, a lively metadisciplinary discussion is still taking place within the discipline, which highlights various challenges or concerns that Applied CL research is currently facing (e.g.,Achard & Niemeier 2004;Pütz 2010;Roche 2014;Tyler & Huang 2018). Major concerns in this discussion are, for instance, (1) the underuse of empirical data in Applied CL research and (2) the yet limited application of CL theories to Communicative Language Teaching (as opposed to Present-Practice-Produce, in which it is typically embedded). This article outlines these two challenges to research in Applied CL and offers suggestions how to address these concerns in future investigations. By doing so, we intend to contribute to the ongoing metadisciplinary discussion about the Applied CL framework and to promote its further consolidation.
Correlated barrier charge hopping and non-Debye relaxation in columbite MnNb2O6
Authors: R Maruthi , Deshpande S K , Deshmukh V , Singh K , Thota S 
Published: November 2022

Abstract
A comprehensive study on the mechanism of ac-charge transport and dielectric relaxation in the MnNb2O6 columbite system has been reported. Thermally driven, Arrhenius-like behaviour of the ac-conductivity

(
σ
(
ω
,
T
)
)

is predominant at temperatures above 300 K in the frequency range 50 Hz–5 MHz with activation energies

(

E

a
c

)

lying between 0.45 and 0.38 eV. Besides, a quadratically decreasing trend in the activation energy is evident as given by:

E

a
c

(
f
)

= A + Bf + Cf
2 with the constants A (0.413 eV), B (0.023 eV Hz−1) and C (−0.004 eV Hz−2). The measured

σ
(
ω
,
T
)

data is analysed using the Double power law to explain the dispersive behaviour of electrical conductivity. These studies also provide evidence for the correlated-barrier hopping (CBH) conduction mechanism of charge carriers for temperatures in the range 173–473 K. Further, the temperature dependence of frequency exponent, s(T) displays two distinct regions both of which are associated with the CBH mechanism with slopes

∂

s
1

/

∂
T
=
−
1.9
×

10

−
3

K−1 and

∂

s
2

/

∂
T
=
−
1.3
×

10

−
3

K−1 in Region-I (173–300 K) and the slope

∂

s
1

/

∂
T
=
−
1.7
×

10

−
3

K−1 with non-linear variation of s
2 in Region-II (300–473 K). However, the second region is more dominated by thermally activated Arrhenius-like behaviour. The dynamical response of complex electric modulus spectra

(

M
∗

(
ω
,
T
)
)

and the corresponding analysis using Kohlrausch-Williams-Watts method reveals the presence of a non-Debye type relaxation process with decay function exponent β lying between 0.794 and 0.840. This inference of the non-Debye type relaxation process is further supported by depressed semicircles in Nyquist plots and the higher magnitude of full width half maximum (FWHM) (≈1.44 decades) of the normalized master cusp

(

M

′
′

/

M

m
a
x

′
′

vs

ω

/

ω

m
a
x

)

compared to the FWHM ( = 1.14 decades) for ideal Debye behaviour. Both short-range and long-range conductivity regions are ubiquitous in

(

M
∗

(
ω
,
T
)
)

with a pronounced distribution of relaxation times (

τ
≈
935.8
−
0.36
μ

s) with temperature. This study further leads to the estimation of activation energy of charge carriers, E

M
= 0.44 eV which is in consonance with

E

a
c

(
f
,
T
)

.
Effect of goat manure and NPK fertilizer against the growth and production of tomato plants (Lycopersicon esculentum)
Authors: Purnomo Joko , Miftakhurrohmat A. , Prihatiningrum Andriani Eka 
Published: November 2022

Abstract
This study aims to determine the effect of goat manure and NPK fertilizer on the growth and production of tomato (Lycopersicon Esculentum). The research was conducted in the village of Jiken, Tulangan District, Sidoarjo Regency, from June to August 2020. The experiment was arranged in a factorial using a randomized block design. The first factor is the manure dosage consisting of 0 and 10 tons / ha, while the second factor is the NPK fertilizer dosage consisting of 0, 50, 150, 250, and 350 kg / ha. The experiment was repeated 3 times in order to obtain 30 experimental units. The variables observed were plant height (cm), number of leaves (strands), leaf area (cm2), stem diameter (mm) and vitamin C content (%). Observation data will be analyzed with ANOVA 5% followed by the BNJ 5% test to determine the differences between treatments. The results showed that there was no significant interaction between the dosage treatment of goat manure and NPK fertilizer on all observation variables. Meanwhile, the manure dose treatment showed a significant effect on the variable weight of tomato fruit.
Oleoresin Production and Turpentine Component of Pinus oocarpa and Pinus merkusii
Authors: Sukarno Agus , Sutarman  , Mondiana Yani Quarta , Irawan Dedy Wahyu , Wiranegara Yudo Aria , Abror Muhammad 
Published: November 2022

Abstract
This study aims to determine differences in oleoresin production and the type and content of turpentine P. oocarpa and P. merkusii. The first stage of the research activity was to collect oleoresin obtained from 15 plants of each type of pine aged 14 years which were determined randomly. Determination of the type and content of phytochemicals, especially turpentine using Gas Chromatography-Mass Spectrometry by injecting gas-phase chemical isolates. The oleoresin tapping data were analyzed by paired t-test with a test level of 5% to determine the difference in the amount of oleoresin. The results showed that there was no difference in production capacity (p<0.05) between the two stands with an average oleoresin production per tree of 0.0127±0.002 g.d-1 (P. oocarpa) and 0.0183±0.003 g.d-1 (P. merkusii). The most important species in P. oocarpa consisted of: α-pinene (5.2%), ß-pinene (5.8%), and delta 3 carena (13.8%); while in P. merkusii are α-pinene (8.2%), ß-pinene (11.5%), limonene (5.2%), α-terpinolene (32.7%), benzenemethanol (4.3%), and trans-pinocarveol (3.5%). All turpentine compounds produced by the two types of pine can be used for various pharmaceutical, cosmetic, and pesticide industries.
Effect of Boron Fertilizer and of Potassium Fertilizer on Growth and Production of Purple Eggplant (Solanum Melongena L.)
Authors: Sari Fanny Martha , Abror M. , Arifin Saiful 
Published: November 2022

Abstract
This study aims to determine the response of boron and potassium fertilizers on the growth and production of purple eggplant (Solanum melongena L.). The research was conducted in the village of Jiken, Kec. Tulang, Sidoarjo Regency and continued in the microbiology and biotechnology laboratory of the Muhammadiyah University of Sidoarjo. Starting from February to May 2020. The experiment was arranged factorially using a randomized block design followed by the 5% BNJ test consisting of 2 factors. The first factor is boron fertilizer with levels of 0 kg/ha, 6 kg/ha and 12 kg/ha. The second factor was potassium fertilizer which consisted of 3 treatment doses, namely 50 kg/ha, 100 kg/ha and 150 kg/ha. The variables observed were plant height, leaf area, number of leaves, number of fruits, fruit weight, fruit length, fruit sweetness,antioxidant levels. The results showed that there was no significant interaction in each treatment, this is because boron fertilizer decreased at the last observation in the study. While the antioxidan test in this study used free radical damping method with DPPH with wavelength of 517 nm using spectrophotometer.