bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone marrow necrosis and fat embolism syndrome in sickle cell disease during COVID‐19 infection treated successfully with sequential red cell and plasma exchange
Authors: Rizvi Syed , Khakwani Muhammad , Pancham Shivan , Tsitsikas Dimitris , Rudzki Zbigniew , Hassan‐Smith Ghaniah , Bowen Michael , Wright Christine , Park Daniel 
Published: December 2022

AbstractFat embolism syndrome (FES) is a rare life‐threatening condition that is particularly seen in milder forms of sickle cell disease (SCD). Widespread systemic fat emboli are generated in the context of extensive bone marrow necrosis. Multi‐organ failure with a high morbidity and mortality may quickly develop. Infection with Parvovirus B19 is a common precipitant.Here, the authors report the case of a 35‐year‐old Afro‐Caribbean man with HbSC disease who presented with FES having tested positive for SARS‐COV‐2. He rapidly became critically ill and required admission to the intensive care unit for organ support. He was treated with red cell exchange and plasma exchange and made a good recovery to leave hospital at week 7.
The effect of post‐brew holding time and carafe type on the sensory properties of drip brew coffee
Authors: Batali Mackenzie E. , Cotter Andrew R. , Lim Lik Xian , Ristenpart William D. , Guinard Jean‐Xavier 
Published: December 2022

AbstractBackgroundCoffee quality is believed to degrade quickly after brewing, and retail establishments discard unsold brewed coffee after a specified holding time period, sometimes as short as 30 min. We used trained sensory panels to evaluate the flavor profiles of light, medium, and dark roast coffees held in three different carafe types (glass on hot plate, thermal jacket, and vacuum insulated) for times ranging from 15 min to 3 h. Furthermore, a panel of 93 coffee‐industry professionals performed a blind evaluation of fresh (30 min) versus held (180 min) coffee for overall liking and attribute level adequacy.ResultsSourness increased over time, consistent with acidity increasing over time (i.e., higher titratable acidity, lower pH), but only for the light and medium roasts. Dark roasted coffee became significantly more acidic over 3 h post‐brew but was not perceived as more sour over time by the sensory panel. Variations were observed between the thermal jacket and vacuum carafes for the light and dark roast, but few differences were observed with storage type in the medium roast. Surprisingly, the panel of coffee industry professionals showed no preference for fresh over held.ConclusionsMore sensory attributes decreased than increased over time, suggesting that the primary concern with loss of quality during coffee holding may be the loss of volatile aroma compounds. Hedonic ratings suggest that even if the changes over time are noticeable, they may not negatively impact overall liking. © 2022 Society of Chemical Industry.
Postoperative opioid‐prescribing practices in otolaryngology: Evidence‐based guideline outcomes
Authors: Rana Tanvi , Daniels Kelly , Dang Sophia , Li Jonathan C. , Freeman Cecilia G. , Duffy Alexander , Curry Joseph , Luginbuhl Adam , Cottrill Elizabeth , Cognetti David 
Published: December 2022

AbstractObjectivesWe previously reported that >50% of postoperative opioids prescribed at our institution went unused for common otolaryngologic procedures. Based on these findings, we instituted multimodal, evidence‐based guidelines for postoperative pain management. In the second part of our multiphasic study, we evaluated the effects of these guidelines on (1) quantity of unused opioids, (2) patient satisfaction, and (3) institutional perceptions toward the opioid epidemic and prescribing guidelines.MethodsStandardized, procedure‐specific opioid prescription guidelines were created using prospective data from the first phase of our study and evidence from current literature. Again, we examined sialendoscopy, parotidectomy, parathyroidectomy/thyroidectomy, and transoral robotic surgery (TORS). Patients were surveyed at their first postoperative appointment. Groups from Phases I and II were compared. Attending physicians were surveyed before the start of the multiphasic project and after prescribing guidelines were implemented.ResultsPrescribing guidelines led to an average reduction in prescribed morphine milligram equivalents (MME) per patient by: 48% (sialendoscopy), 63% (parotidectomy), 60% (para/thyroidectomy), and 42% (TORS). Average used MME per patient for parotidectomy was significantly reduced (64%). The proportion of unused MME per patient and patient satisfaction scores did not significantly change after guidelines were implemented.ConclusionImplementation of opioid‐prescribing guidelines and the use of multimodal analgesia substantially reduced the amount of opioids prescribed across all procedures without impacting patient satisfaction.Level of Evidence2
Development of 3D‐Printed, Biodegradable, Conductive PGSA Composites for Nerve Tissue Regeneration
Authors: Huang Wei‐Jia , Wang Jane 
Published: December 2022

AbstractNerve conduits are used to reconnect broken nerve bundles and provide protection to facilitate nerve regeneration. However, the low degradation rate and regeneration rate, as well as the requirement for secondary surgery are some of the most criticized drawbacks of existing nerve conduits. With high processing flexibility from the photo‐curability, poly (glycerol sebacate) acrylate (PGSA) is a promising material with tunable mechanical properties and biocompatibility for the development of medical devices. Here, polyvinylpyrrolidone (PVP), silver nanoparticles (AgNPs), and graphene are embedded in biodegradable PGSA matrix. The polymer composites are then assessed for their electrical conductivity, biodegradability, three‐dimensional‐printability (3D‐printability), and promotion of cell proliferation. Through the four‐probe technique, it is shown that the PGSA composites are identified as highly conductive in swollen state. Furthermore, biodegradability is evaluated through enzymatic degradation and facilitated hydrolysis. Cell proliferation and guidance are significantly promoted by three‐dimensional‐printed microstructures and electrical stimulation on PGSA composites, especially on PGSA‐PVP. Hence, microstructured nerve conduits are 3D‐printed with PGSA‐PVP. Guided cell growth and promoted proliferation are subsequently demonstrated by Schwann cell culture combined with electrical stimulation. Consequently, 3D‐printed nerve conduits fabricated with PGSA composites hold great potential in nerve tissue regeneration through electrical stimulation.
Photosensitive Benzoxazines Derived from Divanillidene Cyclopentanone/Cyclohexanone for Hydrophobic and Optical Applications
Authors: Appasamy Subasri , Arumugam Hariharan , Krishnasamy Balaji , Muthukaruppan Alagar 
Published: December 2022

AbstractAn attempt is made to synthesize two series of photosensitive benzoxazines using a divanillidene cyclopentanone/divanillidene cyclohexanone (DVCP/DVCH) core containing structurally different amines such as aniline, cyclohexylamine, 4‐aminobenzonitrile, furfurylamine, and stearylamine with paraformaldehyde through Mannich condensation reaction. The molecular structure of the synthesized benzoxazines is confirmed from Fourier transform infrared and proton nuclear magnetic resonance (1H‐NMR) spectroscopic analyses. The curing behavior and thermal stability of the benzoxazines are analyzed using differential scanning calorimetry and thermogravimetric analysis, respectively. Both DVCP and DVCH core benzoxazines are cured by thermal and photocuring methods. Cyclopentanone core containing benzoxazines exhibit higher thermal stability when compared with that of most of the cyclohexanone core containing benzoxazines. The DVCP and DVCH core benzoxazines exhibit excellent hydrophobic behavior and good self‐extinguishing properties. The photolysis of DVCP‐ and DVCH‐based benzoxazines indicates that the α,β‐unsaturated ketone moiety in the main chain dimerizes through 2π+2π cycloaddition reaction to form a cyclobutane derivative and leads to crosslinking. The photosensitivity of the benzoxazine decreases with an increase in the size of the cycloalkanone ring. The band gap energy (Eg) calculated from absorption spectra is found between 3.0 and 3.29 eV.
International Society for Prenatal Diagnosis 2022 DEBATE: There should be formal accreditation and ongoing quality assurance/review for units offering fetal therapy that includes public reporting of outcomes
Authors: Moldenhauer Julie S. , Johnson Anthony , Van Mieghem Tim 
Published: December 2022

AbstractThe field of fetal therapy has so far escaped from formal accreditation and quality control. Despite that, current published evidence shows that outcomes of interventions in younger fetal therapy centers are similar to what is achieved in more experienced centers and outcomes of interventions have improved over time. The question however remains what is not being published and what should be the standard of care, given the lack of level 1 evidence from randomized controlled trials for many interventions. Formal collaborative networks such as NAFTnet and others allow for anonymized benchmarking of center outcomes, without publicly shaming (and financially punishing) underperforming centers. Large registries also allow for tracking of rare complications and may result in improved patient outcomes over time. Core outcome sets, which could serve as a basis for outcome reporting, are available for some conditions, but certainly not for all, resulting in communication difficulties between centers. Formal accreditation, quality control, and outcome reporting are hard to implement, expensive, and may result in decreasing access to care by pushing smaller centers out of the market. Despite the existing difficulties, international societies have committed to quality improvement, and fetal therapy programs are strongly recommended to participate in voluntary outcome tracking.
ATAC‐seq exposes differences in chromatin accessibility leading to distinct leaf shapes in mulberry
Authors: Wang Lei , Feng Yuming , Wang Jiangying , Jin Xin , Zhang Qiaonan , Ackah Michael , Wang Yuhua , Xu Dayong , Zhao Weiguo 
Published: December 2022

AbstractMulberry leaf shape is an important agronomic trait indicating yield, growth, development, and habitat variation. China was the earliest country in the world to grow mulberry for sericulture, and it is also one of the great contributions of the Chinese nation to human civilization. ATAC‐seq (Assay for Transposase Accessible Chromatin using sequencing) is a recently developed technique for genome‐wide analysis of chromatin accessibility. The samples used for ATAC sequencing in this study were divided into two groups of whole leaves (CK‐1 and CK‐2) and lobed leaves (HL‐1 and HL‐2), with two replicates in each group. The related motif analysis, differential expression motif screening, and functional annotation of mulberry leaf shape differences were performed by raw letter analysis to finally obtain the transcription factors (TFs) that lead to the production of heteromorphic leaves. These transcription factors are common in plants, especially the TCP family, shown to be associated with leaf development and growth in other woody plants and are a potential transcription factor responsible for leaf shape differences in mulberry. Dissecting the regulatory mechanisms of leaf shape of different forms of mulberry leaves by ATAC‐seq is an important way to protect mulberry germplasm resources and improve mulberry yield. It is conducive to cultivating mulberry varieties with high resistance to adversity, promoting the sustainable development of sericulture, and protecting and improving the ecological environment.
An experimental vibrational spectroscopic and density functional theory computational study on 2,4‐dioxopyrimidine in solvation phase
Authors: Badoğlu Serdar , Yurdakul Şenay 
Published: December 2022

AbstractIn this study, experimental ATR FTIR spectrum of 2,4‐dioxopyrimidine is recorded in solid phase. Its vibrational frequencies and modes were determined. Density functional theory calculations are employed to determine the ground‐state geometry and vibrational frequencies of the title compound. Possible dimeric forms of the molecule were investigated theoretically. A solvation phase experimental ATR FTIR spectrum is recorded in dimethyl sulfoxide (DMSO) solution and vibrational frequencies together with the modes are determined. Solvent effects are included in our calculations by using polarizable continuum model in DMSO. Solid phase and solvation phase experimental spectra are compared with each other.
Current and future opportunities for satellite remote sensing to inform rewilding
Authors: Pettorelli Nathalie , Schulte to Bühne Henrike 
Published: December 2022

AbstractRewilding has been suggested as an effective strategy for addressing environmental challenges such as the intertwined biodiversity and climate change crises, but there is little information to guide the monitoring of rewilding projects. Since rewilding focuses on enhancing ecosystem functionality, with no defined endpoint, monitoring strategies used in restoration are often inappropriate, as they typically focus on assessing species composition, or the ecological transition of an ecosystem towards a defined desired state. We here discuss how satellite remote sensing can provide an opportunity to address existing knowledge and data gaps in rewilding science. We first discuss how satellite remote sensing is currently being used to inform rewilding initiatives and highlight current barriers to the adoption of this type of technology by practitioners and scientists involved with rewilding. We then identify opportunities for satellite remote sensing to help address current knowledge gaps in rewilding, including gaining a better understanding of the role of animals in ecosystem functioning; improving the monitoring of landscape‐scale connectivity; and assessing the impacts of rewilding on the conservation status of rewilded sites. Though significant barriers remain to the widespread use of satellite remote sensing to monitor rewilding projects, we argue that decisions on monitoring approaches and priorities need to be part of implementation plans from the start, involving both remote sensing experts and ecologists. Making use of the full potential of satellite remote sensing for rewilding ultimately requires integrating species and ecosystem perspectives at the monitoring, knowledge‐producing and decision‐making levels. Such an integration will require a change in know‐how, necessitating increased inter‐disciplinary interactions and collaborations, as well as conceptual shifts in communities and organizations traditionally involved in biodiversity conservation.
Deep learning for sustainable agriculture needs ecology and human involvement
Authors: Ryo Masahiro , Schiller Josepha , Stiller Stefan , Rivera Palacio Juan Camilo , Mengsuwan Konlavach , Safonova Anastasiia , Wei Yuqi 
Published: December 2022

AbstractDeep learning is an emerging data analytic tool that can improve predictability, efficiency and sustainability in agriculture. With a bibliometric analysis of 156 articles, we show how deep learning methods have been applied in the context of sustainable agriculture. As a general publication trend, China and India are leading countries for publication, international collaboration is still minor. Deep learning has been popularly applied in the context of smart agriculture across scales for individual plant monitoring, field monitoring, field operation and robotics, predicting soil, water and climate conditions and landscape‐level monitoring of land use and crop types. We identified that the potential of deep learning had been investigated mainly for predicting soil (abiotic), water, climate and vegetation dynamics, but ecological characteristics are critically understudied. We also highlight key themes that can be better addressed with deep learning for fostering sustainable agriculture: (i) including above‐ and belowground ecological dynamics such as ecosystem functioning and ecotone, (ii) evaluating agricultural impacts on other ecosystems and (iii) incorporating the knowledge and opinions of domain experts and stakeholders into artificial intelligence. We propose that deep learning needs to go beyond automatic data analysis by integrating ecological and human knowledge to foster sustainable agriculture.
Temporal variability in soil organic matter accretion rates in coastal deltaic wetlands under changing depositional environments
Authors: Sapkota Yadav , Xu Kehui , Maiti Kanchan , Inglett Patrick , White John R. 
Published: December 2022

AbstractThe Mississippi River Deltaic Plain experiences high relative sea level rise, limited sediment supply, and high marsh edge erosion, leading to the substantial coastal wetland and stored soil organic matter (SOM) loss. The objective of this study was to understand the SOM accumulation rates over the past 1000 years related to the changes in the depositional environment in these highly eroding coastal wetlands. Soil cores (2 m) were collected from four sites in Barataria Basin, LA and analyzed for proportion of organic and mineral matter, total C, N, P, particle size, and stable isotopic composition (δ13C and δ15N), as well as 14C and 137Cs dating. The soil carbon stock in the 2 m depth (62.4 ± 2 kg m−2) was approximately 88% greater than the carbon stock in just the 1 m depth (33.1 ± 0.6 kg m−2) indicating a need for considering deeper soil profiles (up to 2 m) to estimate blue carbon stock in deltaic environments. The average vertical accretion rate for Barataria Basin was 8.1 ± 0.6 mm year−1 over 50 years. The long‐term (1000‐year time scale) C accumulation rate (39 g C m−2 year−1) was ∼14% of the short‐term accumulation rate (254 ± 19 g C m−2 year−1). Wetlands in Barataria Basin started as fresh marsh and transitioned over time to intermediate to brackish. These marshes were able to maintain relative elevation through the accumulation of organic matter and mud despite high relative rates of sea‐level rise. However, the high rates of edge erosion may limit these marshes to continue to sequester atmospheric carbon under accelerating sea level in the absence of restoration efforts.
Current landscape in antiviral drug development against herpes simplex virus infections
Authors: Frejborg Fanny , Kalke Kiira , Hukkanen Veijo 
Published: December 2022

AbstractHerpes simplex viruses (HSV) are common human pathogens with a combined global seroprevalence of 90% in the adult population. HSV‐1 causes orofacial herpes but can cause severe diseases, such as the potentially fatal herpes encephalitis and herpes keratitis, a prevalent cause of infectious blindness. The hallmark of HSV is lifelong latent infections and viral reactivations, leading to recurrent lesions or asymptomatic shedding. HSV‐1 and HSV‐2 can cause recurrent, painful, and socially limiting genital lesions, which predispose to human immunodeficiency virus infections, and can lead to neonatal herpes infections, a life‐threatening condition for the newborn. Despite massive efforts, there is no vaccine against HSV, as both viruses share the capability to evade the antiviral defenses of human and to establish lifelong latency. Recurrent and primary HSV infections are treated with nucleoside analogs, but the treatments do not completely eliminate viral shedding and transmission. Drug‐resistant HSV strains can emerge in relation to long‐term prophylactic treatment. Such strains are likely to be resistant to other chemotherapies, justifying the development of novel antiviral treatments. The importance of developing new therapies against HSV has been recognized by the World Health Organization. In this review, we discuss the current approaches for developing novel antiviral therapies against HSV, such as small molecule inhibitors, biopharmaceuticals, natural products, gene editing, and oligonucleotide‐based therapies. These approaches may have potential in the future to answer the unmet medical need. Furthermore, novel approaches are presented for potential eradication of latent HSV.
Bacterial infection microenvironment‐responsive porous microspheres by microfluidics for promoting anti‐infective therapy
Authors: Gao Yang , Ma Qingming 
Published: December 2022

AbstractThe overuse of antibiotics for treating bacterial infection has caused severe bacterial resistance and become a public health threat worldwide. It is desired to develop novel antibiotic delivery systems as efficient antibacterial strategies for promoting anti‐infective therapy. Herein, the AgNPs‐loaded N‐[(2‐hydroxy‐3‐trimethyl ammonium) propyl] chitosan (HTCC)/hyaluronic acid (HA) porous microspheres (HHPMs) by microfluidics have been developed as novel bacterial infection microenvironment (IME)‐responsive antibiotic delivery systems for promoting antimicrobial therapy. The release of AgNPs can respond explicitly to the IME with acidic pH values and relatively high hyaluronidase concentration. The unique porous structures of HHPMs can effectively facilitate the capture and enrichment of bacteria, thus exerting synergistic antibacterial effects, which can be more efficient in instant bacteria inhibiting and killing. The excellent biocompatibility of HHPMs is revealed by investigating their hemolytic activity and cytotoxicity. In vivo assays demonstrate that the fabricated AgNPs‐loaded HHPMs can effectively resist bacterial infection and promote wound healing and tissue regeneration at infected wound sites by inhibition of the bacterial survival. This work indicates that fabricated HHPMs are ideal bacterial infection microenvironment‐responsive materials for antibiotic delivery and show great promises for promoting anti‐infective therapy in clinics.
Tuning the Kinetic Trapping in Chemically Fueled Self‐Assembly
Authors: Kriebisch Brigitte A. K. , Kriebisch Christine M. E. , Bergmann Alexander M. , Wanzke Caren , Tena‐Solsona Marta , Boekhoven Job 
Published: December 2022

AbstractThe front cover artwork is provided by BoekhovenLab at TU Munich. The image shows an energy landscape of kinetically trapped chemically fueled supramolecular fibers, which reminds of a mountain landscape. Read the full text of the Research Article at 10.1002/syst.202200035.
Species, God, and Dominion
Authors: Wilkins John S. 
Published: December 2022

AbstractSpecies as a concept is the outcome of theological and philosophical considerations, not empirical or scientific need. It still holds political import for the religious movement of dominionism, with great impact on environmentalist and conservationist politics in the United States and elsewhere in the world. This chapter will argue that having a “theoretical” notion of species is inimical to science and polity. It is not needed, as it retains much of its original essentialistic religious origins and emphasizes human exceptionalism to the detriment of ecological stewardship.
Dilepton Decays of Vector Particles
Authors: Faccioli Pietro , Lourenço Carlos 
Published: December 2022

AbstractThis chapter introduces the basic notions used in the measurement of the polarization of a particle and in its interpretation.We use, as a prototype, the case of a vector particle (the $$\text{J}/\psi$$meson,a virtual photon, the Z boson, etc.) decaying into a lepton-antilepton pair.In particular, we address the general shape of the decay angular distribution, its relation to the particle polarization, the meaning of the relevant parameters, and the main difficulties usually encountered in polarization measurements.