bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a video intervention on physicians’ acceptance of pain apps: a randomised controlled trial
Authors: Hein Hauke Jeldrik , Glombiewski Julia Anna , Rief Winfried , Riecke Jenny 
Published: May 2022

ObjectivesThe aim of our study was to determine and enhance physicians’ acceptance, performance expectancy and credibility of health apps for chronic pain patients. We further investigated predictors of acceptance.DesignRandomised experimental trial with a parallel-group repeated measures design.Setting and participants248 physicians working in various, mainly outpatient settings in Germany.Intervention and outcomePhysicians were randomly assigned to either an experimental group (short video about health apps) or a control group (short video about chronic pain). Primary outcome measure was acceptance. Performance expectancy and credibility of health apps were secondary outcomes. In addition, we assessed 101 medical students to evaluate the effectiveness of the video intervention in young professionals.ResultsIn general, physicians’ acceptance of health apps for chronic pain patients was moderate (M=9.51, SD=3.53, scale ranges from 3 to 15). All primary and secondary outcomes were enhanced by the video intervention: A repeated-measures analysis of variance yielded a significant interaction effect for acceptance (F(1, 246)=15.28, p=0.01), performance expectancy (F(1, 246)=6.10, p=0.01) and credibility (F(1, 246)=25.61, p<0.001). The same pattern of results was evident among medical students. Linear regression analysis revealed credibility (β=0.34, p<0.001) and performance expectancy (β=0.30, p<0.001) as the two strongest factors influencing acceptance, followed by scepticism (β=−0.18, p<0.001) and intuitive appeal (β=0.11, p=0.03).Conclusions and recommendationsPhysicians’ acceptance of health apps was moderate, and was strengthened by a 3 min video. Besides performance expectancy, credibility seems to be a promising factor associated with acceptance. Future research should focus on ways to implement acceptability-increasing interventions into routine care.
Novel genetic variants associated with inhaled corticosteroid treatment response in older adults with asthma
Authors: Wang Alberta L , Lahousse Lies , Dahlin Amber , Edris Ahmed , McGeachie Michael , Lutz Sharon M , Sordillo Joanne E , Brusselle Guy , Lasky-Su Jessica , Weiss Scott T , Iribarren Carlos , Lu Meng X , Tantisira Kelan G , Wu Ann C 
Published: May 2022

IntroductionOlder adults have the greatest burden of asthma and poorest outcomes. The pharmacogenetics of inhaled corticosteroid (ICS) treatment response is not well studied in older adults.MethodsA genome-wide association study of ICS response was performed in asthmatics of European ancestry in Genetic Epidemiology Research on Adult Health and Aging (GERA) by fitting Cox proportional hazards regression models, followed by validation in the Mass General Brigham (MGB) Biobank and Rotterdam Study. ICS response was measured using two definitions in asthmatics on ICS treatment: (1) absence of oral corticosteroid (OCS) bursts using prescription records and (2) absence of asthma-related exacerbations using diagnosis codes. A fixed-effect meta-analysis was performed for each outcome. The validated single-nucleotide polymorphisms (SNPs) were functionally annotated to standard databases.ResultsIn 5710 subjects in GERA, 676 subjects in MGB Biobank, and 465 subjects in the Rotterdam Study, four novel SNPs on chromosome six nearPTCHD4validated across all cohorts and met genome-wide significance on meta-analysis for the OCS burst outcome. In 4541 subjects in GERA and 505 subjects in MGB Biobank, 152 SNPs with p<5 × 10−5were validated across these two cohorts for the asthma-related exacerbation outcome. The validated SNPs included methylation and expression quantitative trait loci forCPED1,CRADDandDSTfor the OCS burst outcome andGM2A,SNW1,CACNA1C,DPH1, andRPS10for the asthma-related exacerbation outcome.ConclusionsMultiple novel SNPs associated with ICS response were identified in older adult asthmatics. Several SNPs annotated to genes previously associated with asthma and other airway or allergic diseases, includingPTCHD4.
Targeted Radionuclide Therapy with Low and High-Dose Lutetium-177–Labeled Single Domain Antibodies Induces Distinct Immune Signatures in a Mouse Melanoma Model
Authors: Ertveldt Thomas , De Beck Lien , De Ridder Kirsten , Locy Hanne , de Mey Wout , Goyvaerts Cleo , Lecocq Quentin , Ceuppens Hannelore , De Vlaeminck Yannick , Awad Robin Maximilian , Keyaerts Marleen , Devoogdt Nick , D'Huyvetter Matthias , Breckpot Karine , Krasniqi Ahmet 
Published: May 2022

Abstract
Targeted radionuclide therapy (TRT) using probes labeled with Lutetium-177 (177Lu) represents a new and growing type of cancer therapy. We studied immunologic changes in response to TRT with 177Lu labeled anti-human CD20 camelid single domain antibodies (sdAb) in a B16-melanoma model transfected to express human CD20, the target antigen, and ovalbumin, a surrogate tumor antigen. High-dose TRT induced melanoma cell death, calreticulin exposure, and ATP-release in vitro. Melanoma-bearing mice received fractionated low and high-dose TRT via tumor targeting anti-human CD20 sdAbs, as opposed to control sdAbs. Tumor growth was delayed with both doses. Low- and high-dose TRT increased IL10 serum levels. Low-dose TRT also decreased CCL5 serum levels. At the tumor, high-dose TRT induced a type I IFN gene signature, while low-dose TRT induced a proinflammatory gene signature. Low- and high-dose TRT increased the percentage of PD-L1pos and PD-L2pos myeloid cells in tumors with a marked increase in alternatively activated macrophages after high-dose TRT. The percentage of tumor-infiltrating T cells was not changed, yet a modest increase in ovalbumin-specific CD8pos T-cells was observed after low-dose TRT. Contradictory, low and high-dose TRT decreased CD4pos Th1 cells in addition to double negative T cells. In conclusion, these data suggest that low and high-dose TRT induce distinct immunologic changes, which might serve as an anchoring point for combination therapy.
Brasis sobrepostos: fontes da conformação e transformação do tempo
Authors: Gouveia Inês , Galvão Luciana Suarez , Garcia Walter 
Published: May 2022

Editorial - O ano de 2022 parece nos convidar para o olho do furacão, com todo o seu caráter celebrativo em torno de efemérides que atualizam e associam 1822, 1922 e 2022. É importante termos atenção, pois, conforme Jacques Le Goff (1990) argumenta, as celebrações têm sido apanágio dos conservadores. Nesses termos, compreendemos que o passado tem sido um tempo decorrido e inerte, o presente, fugaz, e o futuro, um tempo abstrato, ancorado em devir de esperança, progresso, desenvolvimento e revolução. [...]
Quem arrisca perde e ganha: um estudo sobre O sedutor do sertão, de Ariano Suassuna
Authors: Oliveira Fábio José Santos de 
Published: May 2022

Este artigo tem por objetivo analisar um romance de Ariano Suassuna (1927-2014) publicado postumamente: O sedutor do sertão (2020). Apesar de seu aspecto deleitável (o que poderia gerar a impressão de uma escrita facilitada), O sedutor do sertão se mostra uma obra de ampla complexidade compositiva. Fatos históricos da Paraíba, motivos populares, citação de folhetos de cordel e aproveitamento cromático, tudo isso se concentra na elaboração de uma obra rica em detalhes, bem ao estilo de Ariano Suassuna.
Abstract 103: Smooth Muscle Cell Specific Overexpression Of Adamts7 Drives Atherosclerosis Development Through The Remodeling Of The Extracellular Matrix
Authors: Chung Allen , Chang Hyun-kyung , Soni Rajesh , Reilly Muredach P , Bauer Robert C 
Published: May 2022

Genome-wide association studies in humans link ADAMTS7 with coronary artery disease. Subsequent studies in mice showed ADAMTS7 to be proatherogenic, as whole-body knockout (KO) reduced atherosclerosis independent of lipid-lowering. Further studies show that Adamts7 expression is temporarily induced in response to vascular injury, and Adamts7 KO reduces primary smooth muscle cell (SMC) migration ex vivo. However, both the mechanism through which ADAMTS7 influences atherosclerosis progression and the responsible cell type remain unclear.

As ADAMTS7 is secreted, we sought to determine its cleavage targets. We generated an immortalized human SMC line with doxycycline-inducible expression of GFP or ADAMTS7. We analyzed conditioned media from these cells via terminal amine isotopic labeling of substrates (TAILS) proteomics. This method labels new protein N termini, enabling the identification of cleavage products. Overexpression of
Adamts7
enriched extracellular matrix (ECM) peptides such as Col1a1, Col1a2, Col4a2, and fibronectin. Furthermore, KEGG analysis identified ECM receptor interaction and focal adhesion formation as highly enriched pathways in the dataset. These results suggest ADAMTS7 alters SMCs by modulating signaling between cell and ECM.

To examine the cell type that confers the proatherogenic effects of Adamts7, we generated a conditional transgenic ADAMTS7 mouse on the Ldlr knockout background. Given previously described roles for ADAMTS7 in SMC migration and vascular reendothelialization, we crossed these mice to either the Tie2-Cre or Myh11-CreERT2 to overexpress ADAMTS7 in endothelial and SMCs respectively. We found >3-fold increase (p = 0.0002) in plaque burden by en face staining in overexpression of Adamts7 in SMCs compared to controls. In contrast, transgenic overexpression of Adamts7 in endothelial cells is embryonic or perinatally lethal (Chi-squared = 0.0018).
In summary, our transgenic study affirms the proatherogenic effect of increased Adamts7 expression in SMCs in vivo. Furthermore, our TAILS data suggests a dynamic role of ADAMTS7 in cleaving ECM. These studies fill critical knowledge gaps in our understanding of ADAMTS7 biology and help inform potential therapeutic avenues to targeting this enzyme.
Sex‐Related Differences in Clinical Features and In‐Hospital Outcomes of Type B Acute Aortic Dissection: A Registry Study
Authors: Takahashi Toshiyuki , Yoshino Hideaki , Akutsu Koichi , Shimokawa Tomoki , Ogino Hitoshi , Kunihara Takashi , Usui Michio , Watanabe Kazuhiro , Kawata Mitsuhiro , Masuhara Hiroshi , Yamasaki Manabu , Yamamoto Takeshi , Nagao Ken , Takayama Morimasa 
Published: May 2022

Background
The association between female sex and poor outcomes following surgery for type A acute aortic dissection has been reported; however, sex‐related differences in clinical features and in‐hospital outcomes of type B acute aortic dissection, including classic aortic dissection and intramural hematoma, remain to be elucidated.

Methods and Results

We studied 2372 patients with type B acute aortic dissection who were enrolled in the Tokyo Acute Aortic Super‐Network Registry. There were fewer and older women than men (median age [interquartile range]: 76 years [66–84 years], n=695 versus 68 years [57–77 years], n=1677;
P
<0.001). Women presented to the aortic centers later than men. Women had a higher proportion of intramural hematoma (63.7% versus 53.7%,
P
<0.001), were medically managed more frequently (90.9% versus 86.3%,
P
=0.002), and had less end‐organ malperfusion (2.4% versus 5.7%,
P
<0.001) and higher in‐hospital mortality (5.3% versus 2.7%,
P
=0.002) than men. In multivariable analysis, age (per year, odds ratio [OR], 1.06 [95% CI, 1.03–1.08];
P
<0.001), hyperlipidemia (OR, 2.09 [95% CI, 1.13–3.88];
P
=0.019), painlessness (OR, 2.59 [95% CI, 1.14–5.89];
P
=0.023), shock/hypotension (OR, 2.93 [95% CI, 1.21–7.11];
P
=0.017), non–intramural hematoma (OR, 2.31 [95% CI, 1.32–4.05];
P
=0.004), aortic rupture (OR, 26.6 [95% CI, 14.1–50.0];
P
<0.001), and end‐organ malperfusion (OR, 4.61 [95% CI, 2.11–10.1];
P
<0.001) were associated with higher in‐hospital mortality, but was not female sex (OR, 1.67 [95% CI, 0.96–2.91];
P
=0.072).

Conclusions
Women affected with type B acute aortic dissection were older and had more intramural hematoma, a lower incidence of end‐organ malperfusion, and higher in‐hospital mortality than men. However, female sex was not associated with in‐hospital mortality after multivariable adjustment.
Impact of Assimilating Adaptively Thinned AIRS Cloud-Cleared Radiances on the Analysis of Polar Lows and Mediterranean Sea Tropical-Like Cyclone in a Global Modeling and Data Assimilation Framework
Authors: Ganeshan Manisha , Reale Oreste , McGrath-Spangler Erica , Boukachaba Niama 
Published: May 2022

Abstract
Polar lows, and mesoscale convective cyclones bearing resemblance to tropical cyclones but originating outside of the tropics, are storms that are challenging to represent accurately in global analyses and models because of their small size, rapid growth at subsynoptic scales, occurrence in data poor oceanic regions, and difficulties in objectively validating them in analysis. Building on previous positive results obtained with respect to the representation of tropical cyclones (TCs) in a global model, a set of observing system experiments (OSEs) performed using the NASA Goddard Earth Observing System (GEOS, version 5) are investigated, focusing on three case studies—a polar low in the Sea of Okhotsk, a polar low in the Southern Ocean, and a Mediterranean Sea tropical-like cyclone that occurred during the boreal fall season of 2014. Experiments assimilating adaptively thinned cloud-cleared hyperspectral infrared radiances from the Atmospheric Infrared Sounder (AIRS) instrument on board the NASA Aqua satellite, with higher density in the vicinity of each storm and its pre-cyclogenesis environment, and lower density elsewhere, demonstrate a positive impact on the analyzed representation of each storm. The adaptive thinning experiments improve the storm intensity and structure, including vertical alignment, depth, symmetry, strength, and compactness of warm core compared to the reference experiments. The results suggest that jet-level processes associated with extremely strong horizontal velocity gradients as represented in the model analysis can be useful to locate dynamically active regions of the extratropical atmosphere where denser data coverage is likely to improve the analyzed representation of polar lows and other similar marine mesoscale convective cyclones.

Significance Statement
Extratropical maritime mesoscale convective cyclones are short-lived, elusive features that are difficult to represent accurately in global analyses. Previous work by this team demonstrated a positive impact of an adaptive thinning methodology for infrared radiances applied to the tropical cyclone (TC) analysis. The methodology allows a relatively greater volume of radiance data to be assimilated around TCs within a TC-centered moving domain in a global model, yielding an improvement in TC structure and intensity forecast. A similar approach is explored here for two polar lows and a Mediterranean Sea tropical-like cyclone, wherein infrared radiances are more densely assimilated in the vicinity of each storm and its pre-cyclogenesis environment, resulting in a positive impact on the representation of the storm. Strong jet-level horizontal velocity gradients appear to precede each storm, and could be used to automate the adaptive thinning strategy in the future.
A Spatiotemporal Perspective on the 31 May 2013 Tornado Evacuation in the Oklahoma City Metropolitan Area
Authors: Hatzis Joshua J. , Klockow-McClain Kim E. 
Published: May 2022

Abstract
On 31 May 2013, an extremely large and violent tornado hit near the town of El Reno, Oklahoma, a small town in the Oklahoma City metropolitan area. The size and intensity of this tornado, coupled with the fact that it was heading toward Oklahoma City, prompted local broadcasters to warn residents to evacuate their homes and head south if they could not shelter belowground. This warning led to a large-scale evacuation of the metropolitan area and massive traffic jams on the interstates and major highways that could have caused casualties in the hundreds if the tornado had not dissipated before reaching Oklahoma City. The focus of this study was to understand the magnitude of the 31 May 2013 evacuation through the evaluation of traffic volume data and to determine how frequently such evacuations occur in Oklahoma City and other metropolitan areas. We found that of the six metropolitan areas tested, only Oklahoma City had mass anomalous traffic reversal (ATR) days (days with a mass evacuation signal) with 31 May 2013 having the largest mass ATR day by far. Despite the rarity of mass ATR days, the potential consequences of a large, violent tornado hitting gridlocked traffic is significant, and we recommend that communicators encourage more local sheltering options.

Significance Statement
On the evening of 31 May 2013, a large-scale evacuation of the Oklahoma City metropolitan area occurred as a result of a very large and dangerous tornado that had formed near the town of El Reno and was moving east toward Oklahoma City. If the tornado had not dissipated before it reached the city it could have caused hundreds of casualties as it passed over gridlocked roads. We sought to understand the frequency of such mass evacuations and found that no other event in six metropolitan areas studied during 2011–18 could compare. While such evacuations fortunately appear rare, more work should be done to understand why they happen when they do and to connect individuals with better local sheltering options.
Impacts of decision-making process on social justice in the infrastructure equity in Ethiopia
Authors: Desalegn Ambaw , Solomon Negussie 
Published: May 2022

Equity concerns the distribution of resources and is inevitably linked with concepts of fairness and social justice. What are the decision-making processes for fair allocation of infrastructure resources and its effect on social justice in Ethiopia? The article uses structural equation modeling-partial least square software for analysis. Therefore, the article finds that there is infrastructure inequity and social injustice owing to a lack of democratic decision-making and accountability in Ethiopia. Moreover, the Ethiopian government lacks the tools and institutions that provide the foundation for good decision-making processes and democratic accountability. There also exists a low level of social cohesion in Ethiopia today. Hence, the government needs a democratic decision-making process that would bring diverse interests together and solve the lack of intergovernmental relations (IGRs) as well as the lack of democratic accountability to improve citizens’ justice in the infrastructure sector in Ethiopia. As a result, it requires a focus on regional governments’ needs, reacting to their concerns, and keeping them justified on the equitable distribution of infrastructure across regional states in the country. This will also help to save Ethiopia from bloody conflicts. Points for practitioners In practice, the drive for public management is to increase the quality and efficiency of government-provided services. Professions in government agencies, public enterprises, and trusts that deal with policies and strategies that govern the equitable allocation and administration of public resources make up the public management and administration pathway. As a result, the most important takeaway for professionals is that creating a learning organization is a significant management strategy that public organizations must pursue in exercises.
Sustained release of azithromycin from lipid liquid-crystalline nanoparticles laden in situ gel for the treatment of periodontitis: In vitro and efficacy study
Authors: Zheng Jing , Zhang Yuwen , Zhang Suxin 
Published: May 2022

Periodontitis is a chronic inflammatory disease affecting teeth, periodontal ligament and alveolar bone. Current treatment options include surgery or oral antibiotics. Oral dosage forms shows systemic side effects due to frequent dosing and it failed to reach the therapeutic concentration in the periodontal cavity. In this work, a novel in situ gel loaded with azithromycin laden lipid liquid-crystalline nanoparticles (cubosomes) was formulated for effective treatment of periodontitis. Cubosomes were prepared using DL-α-monoolein (MO) and Pluronic®F-127, and characterized for size, zeta potential, shape, and entrapment efficacy. In situ gel laden cubosomes were evaluated for pH, drug content, viscosity, syringeability, mucoadhesive strength, texture profile, gelation temperature, gel strength, in vitro release profile, antimicrobial activity and in vivo efficacy in rat model. Cubosomal size (137–450 nm) and entrapment efficacy (74–88%) increases with increase in the level of MO. The in situ gel-cubosomal batches showed sufficient viscosity (878–956 cp), syringeability (125–150N), mucoadhesive strength (25.7–26.2 dyne/cm2), gelation temperature (34.3–35.3oC), gel strength (45–51 s), and texture profile for periodontal application. The in vitro release profiles showed sustain azithromycin release for 24h from the in situ gel-cubosomal gels compared to 4h from the marketed azithromycin gel. The in vivo studies (alveolar bone loss and histopathology) in rat model confirmed the efficacy of in situ gel to treat periodontitis at low frequency of dosing compared to marketed gel. In conclusion, the study demonstrated the potential of cubosomes to sustain the release of azithromycin from in situ gelling system for effective treatment of periodontitis.
Performance evaluation of electro-spark eroded high-volume fraction of Cr-Fe-Ni superalloy
Authors: Raj Atul , Misra Joy Prakash , Khanduja Dinesh 
Published: May 2022

Current research aims to execute a viability study of electro-spark erosion technique to process Inconel 690, a high-volume fraction of Cr-Fe-Ni superalloy (∼32% Cr). The Box-Behnken design of response surface methodology with varying processing conditions is used to execute the experimental trails. Process performance is examined in terms of material removal rate and surface topography. The surface conditions of the processed surface are studied using scanning electron microscopy. The tool wear character and tribological behavior of the processed surface are also scrutinized to check the post-process consequences. The study explores the formation of oxide layers, craters, spherical droplets, and micro-cracks on the surface processed at Ton: 118 mu; Toff: 45 mu; Ip: 130 mu; Sv: 50 V ( parametrical settings for maximum material removal rate), and at Ton: 118 mu; Toff: 30 mu; Ip: 220 mu; Sv: 50 V ( parametrical settings for maximum surface roughness) attributing a deteriorating surface quality. The maximum material removal rate of 9.38 mm3/min and minimum surface roughness of 0.47 μm are achieved. A significant improvement of approximately 20 HV in micro-hardness is detected owing to the formation of a recast layer on the processed surface. Consequently, a noticeable improvement is observed in the wear resistance of the processed surface.