bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aerobic exercise training‐induced follistatin‐like 1 secretion in the skeletal muscle is related to arterial stiffness via arterial NO production in obese rats
Authors: Inoue Kenichiro , Fujie Shumpei , Horii Naoki , Yamazaki Henry , Uchida Masataka , Iemitsu Motoyuki 
Published: May 2022

AbstractFollistatin‐like 1 (FSTL1), which is mainly secreted from skeletal muscle and myocardium, upregulates protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS) phosphorylation in vascular endothelial cells. It is unclear whether skeletal muscle‐ and myocardium‐derived FSTL1 secretion induced by aerobic exercise training is involved in the reduction of arterial stiffness via arterial NO production in obese rats. This study aimed to clarify whether aerobic exercise training‐induced FSTL1 secretion in myocardium and skeletal muscle is associated with a reduction in arterial stiffness via arterial Akt‐eNOS signaling pathway in obese rats. Sixteen Otsuka Long‐Evans Tokushima Fatty (OLETF) obese rats were randomly divided into two groups: sedentary control (OLETF‐CON) and eight‐week aerobic exercise training (treadmill for 60min at 25m/min, 5days/week, OLETF‐AT). Eight Long‐Evans Tokushima Otsuka (LETO) rats were used as a healthy sedentary control group. In OLETF‐CON, serum FSTL1, arterial Akt and eNOS phosphorylation, and arterial nitrite/nitrate (NOx) levels were significantly lower, and carotid‐femoral pulse wave velocity (cfPWV) was significantly greater than those in LETO. These parameters were improved in the OLETF‐AT compared to the OLETF‐CON. In the OLETF‐AT, FSTL1 levels in slow‐twitch fiber‐rich soleus muscle were significantly greater than those in the OLETF‐CON, but not in myocardium, fast‐twitch fiber‐rich tibialis anterior muscle, and adipose tissue. Serum FSTL1 levels were positively correlated with soleus FSTL1, arterial eNOS phosphorylation, and NOx levels and negatively correlated with cfPWV. Thus, aerobic exercise training‐induced FSTL1 secretion in slow‐twitch fiber‐rich muscles may be associated with a reduction in arterial stiffness via arterial NO production in obese rats.
Cytotoxic activity of guaiane-type sesquiterpene lactone (deoxycynaropicrin) isolated from the leaves of Centaurothamnus maximus
Authors: Nasr Fahd A. , Siddiqui Nasir Ali , ElGamal Ali A. , Al-Massarani Shaza M. , Basudan Omer A. , Abdel-Mageed Wael M. , Alhuzani Mohammed R. , Alqahtani Ali S. 
Published: May 2022

Abstract
Guaianolide is a type of naturally occurring sesquiterpene lactone compounds that have attracted attention due to their diverse biological properties. In this work, a guaiane-type sesquiterpene lactone identified as deoxycynaropicrin (compound 1) was isolated and reported for the first time from the leaves of Centaurothamnus maximus with two known flavonoid derivatives namely luteolin 6-O-methyl ether (compound 2) and quercetin 3-methyl ether 5-O-glucopyranoside (compound 3). The cytotoxic activity of all the three compounds was evaluated against the THP-1 human leukemia cell lines. Moreover, flow cytometry was employed to explore the cell cycle arrest and apoptosis induction for the active compound. We found that compound 1 (deoxycynaropicrin) exerted the highest cytotoxicity while compounds 2 and 3 showed no activity. Cell cycle analysis showed that compound 1 arrested the cells’ population at the G2/M phase. Furthermore, THP-1 cells treated with compound 1 exhibited a marked increase in the apoptotic cells compared to the control. Overall, this study showed that deoxycynaropicrin induces cytotoxicity against human leukemia cell lines and provided an important insight into its potential therapeutic effects against leukemia cells.
Investigation on an anti-corrosion Cu-rich multiple-principal-element alloy strengthened and toughened by nano-scaled L12-type ordered particles
Authors: Jin Chengyan , Du Xinghao , Li Wanpeng , Chen Wenyu , Yan Fei , Shi Chuanxin , Chou Tzu-Hsiu , Chih-Ching Huang Jacob 
Published: May 2022

Abstract
In this study, the microstructure and mechanical properties of a Cu-rich multiple-principal-element alloy with the composition (Cu50Ni20Cr20Mn10)95Al5 (at.%) were investigated. It was found that after 900 °C/1 h annealing process, the as-cast alloy has achieved promising mechanical properties with a yield stress of 510 MPa, an ultimate tensile stress of 820 MPa and tensile elongation of 30 %. These properties are superior to those of traditional nickel–aluminum bronze (NAB) alloys. Moreover, the as-annealed alloy exhibited much better anti-corrosion properties with respect to the NBA alloys. Transmission electron microscopy observations showed that high-number-density nano-scaled L12-type ordered particles have precipitated in the Cu-rich phase after heat treatment and this was regarded as the main mechanism responsible for the enhancement of yield stress.
A unifying causal framework for analyzing dataset shift-stable learning algorithms
Authors: Subbaswamy Adarsh , Chen Bryant , Saria Suchi 
Published: May 2022

AbstractRecent interest in the external validity of prediction models (i.e., the problem of different train and test distributions, known asdataset shift) has produced many methods for finding predictive distributions that are invariant to dataset shifts and can be used for prediction in new, unseen environments. However, these methods consider different types of shifts and have been developed under disparate frameworks, making it difficult to theoretically analyze how solutions differ with respect to stability and accuracy. Taking a causal graphical view, we use a flexible graphical representation to express various types of dataset shifts. Given a known graph of the data generating process, we show that all invariant distributions correspond to a causal hierarchy of graphical operators, which disable the edges in the graph that are responsible for the shifts. The hierarchy provides a common theoretical underpinning for understanding when and how stability to shifts can be achieved, and in what ways stable distributions can differ. We use it to establish conditions for minimax optimal performance across environments, and derive new algorithms that find optimal stable distributions. By using this new perspective, we empirically demonstrate that that there is a tradeoff between minimax and average performance.
Integrative analysis of chemical properties and functions of drugs for adverse drug reaction prediction based on multi-label deep neural network
Authors: Das Pranab , Yogita  , Pal Vipin 
Published: May 2022

Abstract
The prediction of adverse drug reactions (ADR) is an important step of drug discovery and design process. Different drug properties have been employed for ADR prediction but the prediction capability of drug properties and drug functions in integrated manner is yet to be explored. In the present work, a multi-label deep neural network and MLSMOTE based methodology has been proposed for ADR prediction. The proposed methodology has been applied on SMILES Strings data of drugs, 17 molecular descriptors data of drugs and drug functions data individually and in integrated manner for ADR prediction. The experimental results shows that the SMILES Strings + drug functions has outperformed other types of data with regards to ADR prediction capability.
Strategies for the prevention of maternal death from venous thromboembolism clinical recommendations based on current literature
Authors: Rath Werner H. , Stelzl Patrick 
Published: May 2022

Abstract
Venous thromboembolism (VTE) is one of the leading causes of direct maternal deaths. It has been estimated that approximately 50% of these deaths are potentially preventable. The UK Confidential Enquiries into Maternal Deaths and the National Partnership for Maternal Safety have proposed strategies for the prevention of maternal deaths from VTE based on current guideline recommendations.
The main strategies include:

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Early recognition and comprehensive assessment of risk factors for VTE at different times from the beginning of pregnancy until patient’s discharge from hospital.

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Appropriate risk stratification using standardized VTE risk assessment tools (e.g. the Royal College Scoring System).

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Risk–based antenatal and postnatal heparin thromboprophylaxis adjusting the heparin dosage and the duration of prophylaxis to the individual patient’s risk.

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Adequate management of heparin prophylaxis before and after delivery.

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Preference of universal rather than selective post-cesarean heparin thromboprophylaxis and application of perioperative mechanical prophylaxis.

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Avoidance of gaps in the postpartum prescription of heparin.

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Good communication and cooperation between primary and secondary care including community midwifery staff in the postpartum period.

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Immediate intravenous administration of (unfractionated) heparin, if pulmonary embolism is suspected.

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Critical analysis of all thromboembolic events, particularly in association with maternal death to learn from failures and to realize, if and where improvement is needed.

Adequate pharmacological thromboprophylaxis has the potential to reduce the risk of VTE by 60–70% in pregnant women at increased risk.
Langley’s Great Escape
Authors: Winkler David F. 
Published: May 2022

Abstract
The year 2022 will mark the centennial of the commissioning of the US Navy’s first aircraft carrier USS Langley. In late 1936, the ship was converted to become a seaplane tender and in 1939 is deployed to Manila. Following news reaching Admiral Hart and the Asiatic Fleet of the Japanese attack on Pearl Harbor, the arrival of Japanese bombers over Manila is imminent and the Langley is determined to be vulnerable to air attack. Departing Manila on December 9, Langley’s skipper Capt. Felix Stump served as the officer in tactical command of a convoy that also included the oilers Trinity and Pecos and is able to work his way through the archipelago, meeting up with the cruisers Houston and Boise which pick up the escort duties. Reaching Darwin before the end of the year, Stump turns over command to his executive officer Cdr. Robert McConnell to join the staff of the newly formed America British Dutch Australian combined command (ABDACOM) combined command under Vice Adm. William A. Glassford. Unfortunately, Langley will be lost on February 27, 1942, during a desperate attempt to transport Army P-40 pursuit planes to support Dutch efforts to defend Java.
Investigating the Properties of Folded Parchment – A Preliminary Study
Authors: Garside Paul , Dekeyser Camille 
Published: May 2022

Abstract
Parchment manuscripts form an important part of many historic collections. They are often found folded, with some displaying multiple fold patterns resulting from changing uses over their history. Parchment is a potentially fragile medium and folding can increase its susceptibility to damage, as well as hampering access and display. Treatment to address these issues may involve the relaxation of the folded structure, using humidification or a solvent such as propanol, and gentle pressing or stretching. However, this presents a dilemma – an inappropriately folded manuscript may be more prone to damage, but treatments require invasive interventions. This preliminary study has employed infrared spectroscopy and shrinkage temperature measurements to better understand the properties of folded parchment. It demonstrates that physicochemical changes can be detected at the fold and, to a lesser extent, in adjacent areas, compared to the bulk material, and that monitoring these changes allows the impact of different treatment methods to be assessed. This provides a basis for further research into the effect of both the original folding and of potential treatment methods, to inform conservation decisions and help ensure appropriate, effective, and sympathetic outcomes.
Review on optofluidic microreactors for photocatalysis
Authors: Wang Lei , Huang Ziyu , Yang Xiaohui , Rogée Lukas , Huang Xiaowen , Zhang Xuming , Lau Shu Ping 
Published: May 2022

Abstract
Four interrelated issues have been arising with the development of modern industry, namely environmental pollution, the energy crisis, the greenhouse effect and the global food crisis. Photocatalysis is one of the most promising methods to solve them in the future. To promote high photocatalytic reaction efficiency and utilize solar energy to its fullest, a well-designed photoreactor is vital. Photocatalytic optofluidic microreactors, a promising technology that brings the merits of microfluidics to photocatalysis, offer the advantages of a large surface-to-volume ratio, a short molecular diffusion length and high reaction efficiency, providing a potential method for mitigating the aforementioned crises in the future. Although various photocatalytic optofluidic microreactors have been reported, a comprehensive review of microreactors applied to these four fields is still lacking. In this paper, we review the typical design and development of photocatalytic microreactors in the fields of water purification, water splitting, CO2 fixation and coenzyme regeneration in the past few years. As the most promising tool for solar energy utilization, we believe that the increasing innovation of photocatalytic optofluidic microreactors will drive rapid development of related fields in the future.
Empirical Research on the Federal Constitutional Court of Germany. A Short Report on the State of the Art in Political Science
Authors: Lembcke Oliver W. 
Published: May 2022

AbstractThe article undertakes an overall view of the political science contributions to federal constitutional court research in the last 15 years. It assigns the development strands to different designs and theoretical paradigms. What follows is a brief introduction into the relationship between the rule of law and constitutional courts and a short review of the relevant impulses and favoring factors within the German-speaking research landscape for this branch of research. This overview reviews then three research fields – rationalities of action, networks, and impact – are examined in more detail and their innovations and desiderata.
Bemerkungen zum Nachleben antiker Feldherrn- und Herosporträts in den Geschichtswerken der Humanisten
Authors: Galántai Erzsébet 
Published: May 2022

The revival of Elias Corvinus.
The acts of the two famous Hunyadis, János(John), the prominent fighter against the Turks and his son, Mátyás (Matthias King from 1458 to 1490) were described by several literary works throughout Europe.These works abound in references to the antique literature. The autor's aim is to present some references and reminiscences related to the antique Roman literature that can be detected in Elias Corvinus' (1537-1602) work.
Символы великокняжеской власти в средние века (по данным духовных грамот московских великих князей)
Authors: Bótor Tímea 
Published: May 2022

Symbols of power in the wills of the Grand Princes of Moscow (14th– 15th Centuries)
After a thorough examination of the valuables listed in the will, I came to the conclusion that symbols of the later autocratic political power (gold cap, barmy, carneol box, gold chain with cross) first became part of the inheritance of the eldest son in the will of Vasily II in 1462. It was during the reign of Vasily II that they acquired a prominent role and became the regal symbols of the first-born son, the future Grand Prince.
Specific N‐glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning
Authors: Rahman Maisha , Ramirez‐Suarez Nelson J , Diaz‐Balzac Carlos A , Bülow Hannes E 
Published: May 2022

AbstractN‐glycans are molecularly diverse sugars borne by over 70% of proteins transiting the secretory pathway and have been implicated in protein folding, stability, and localization. Mutations in genes important for N‐glycosylation result in congenital disorders of glycosylation that are often associated with intellectual disability. Here, we show that structurally distinct N‐glycans regulate an extracellular protein complex involved in the patterning of somatosensory dendrites in Caenorhabditis elegans. Specifically, aman‐2/Golgi alpha‐mannosidase II, a conserved key enzyme in the biosynthesis of specific N‐glycans, regulates the activity of the Menorin adhesion complex without obviously affecting the protein stability and localization of its components. AMAN‐2 functions cell‐autonomously to allow for decoration of the neuronal transmembrane receptor DMA‐1/LRR‐TM with the correct set of high‐mannose/hybrid/paucimannose N‐glycans. Moreover, distinct types of N‐glycans on specific N‐glycosylation sites regulate DMA‐1/LRR‐TM receptor function, which, together with three other extracellular proteins, forms the Menorin adhesion complex. In summary, specific N‐glycan structures regulate dendrite patterning by coordinating the activity of an extracellular adhesion complex, suggesting that the molecular diversity of N‐glycans can contribute to developmental specificity in the nervous system.
Impact of parathyroidectomy on quality of life in multiple endocrine neoplasia type 1
Authors: Brescia Marília D’Elboux Guimarães , Rodrigues Karine Candido , d’Alessandro André Fernandes , Alves Filho Wellington , van der Plas Willemijn Y , Kruijff Schelto , Arap Sergio Samir , Toledo Sergio Pereira de Almeida , Montenegro Fábio Luiz de Menezes , Lourenço Delmar Muniz 
Published: May 2022

Background
Potential influences of parathyroidectomy (PTx) on the quality of life (QoL) in multiple endocrine neoplasia type 1-related primary hyperparathyroidism (HPT/MEN1) are unknown.

Method
Short Form 36 Health Survey Questionnaire was prospectively applied to 30 HPT/MEN1 patients submitted to PTx (20, subtotal; 10, total with autograft) before, 6 and 12 months after surgery. Parameters that were analyzed included QoL, age, HPT-related symptoms, general pain, comorbidities, biochemical/hormonal response, PTx type and parathyroid volume.

Results
Asymptomatic patients were younger (30 vs 38 years; P = 0.04) and presented higher QoL scores than symptomatic ones: Physical Component Summary score (PCS) 92.5 vs 61.2, P = 0.0051; Mental Component Summary score (MCS) 82.0 vs 56.0, P = 0.04. In both groups, QoL remained stable 1 year after PTx, independently of the number of comorbidities. Preoperative general pain was negatively correlated with PCS (r = −0.60, P = 0.0004) and MCS (r = −0.57, P = 0.0009). Also, moderate/intense pain was progressively (6/12 months) more frequent in cases developing hypoparathyroidism. The PTx type and hypoparathyroidism did not affect the QoL at 12 months although remnant parathyroid tissue volume did have a positive correlation (P = 0.0490; r = 0.3625) to PCS 12 months after surgery. Patients with one to two comorbidities had as pre-PTx PCS (P = 0.0015) as 12 months and post-PTx PCS (P = 0.0031) and MCS (P = 0.0365) better than patients with three to four comorbidities.

Conclusion
A variable QoL profile was underscored in HPT/MEN1 reflecting multiple factors associated with this complex disorder as comorbidities, advanced age at PTx and presence of preoperative symptoms or of general pain perception. Our data encourage the early indication of PTx in HPT/MEN1 by providing known metabolic benefits to target organs and avoiding potential negative impact on QoL.
De heridas y montajes
Authors: Patiño Moscoso Iván Mauricio 
Published: May 2022

Sobre la obra de Lesivo Bestial.
Lesivo Bestial
Impresor y artista gráfico. A finales del 2004 inició su proyecto de arte urbano, utilizando la imagen como elemento de comunicación visual, que reproduce en espacios de acceso público permitiendo un acercamiento más plural a su obra. El esténcil y la serigrafía, además de ser su oficio, son las técnicas con las que crea murales e imprime calcomanías y carteles, posibilitando una dinámica de autonomía en la creación, producción y difusión de su propuesta. Algunos de los temas que aborda en su trabajo son: el militarismo, la educación, el trabajo, la política, los medios de comunicación, la sociedad de consumo, la crisis ambiental, entre otros. Así mismo, en la creación de sus personajes, parte de montajes hechos de catálogos, revistas, diccionarios, instructivos y folletos inspirados en la estética publicitaria de las décadas de 1930 y 1960.
e-mail: lesivo.expresart@gmail.com
Mentir y colonizar. Obediencia inconsciente y subjetividad neoliberal (reseña)
Authors: Patiño Moscoso Iván Mauricio 
Published: May 2022

Reseña:
Merlin, Nora. Mentir y colonizar. Obediencia inconsciente y subjetividad neoliberal. Buenos Aires: Letra Viva, 2019. 142 páginas.
Stress degradation studies and development of validated stability indicating densitometric method for estimation of alpha lipoic acid in bulk and capsule dosage form
Authors: Srivastava Shruti , Dhaneshwar Suneela , Kawathekar Neha 
Published: May 2022

AbstractA precise, sensitive, specific and accurate stability indicating densitometric method was developed and validated for alpha-lipoic acid (ALA) in bulk and capsule dosage form. The study employed pre-coated silica gel 60F254 TLC plates as stationary phase and toluene: chloroform: methanol: formic acid (5:3:1:0.05; v/v/v/v) as mobile phase. The developed method furnished compact spots of alpha-lipoic acid (Rf 0.28 ± 0.05) after derivatization, offered good linearity in range 80–400 ng/spot with correlation coefficient of 0.998. The values for detection and quantitation were found 18.022 and 54.612 ng/spot respectively. ALA was subjected to stress degradation studies and total 13 degradation products were resolved. Thus, the proposed method offered good results according to ICH guidelines, and can be used for identification, routine quantitative determination as well as for monitoring the stability of ALA in bulk and in capsules.
Ethnic conciliation in parliaments: Western Balkans v. Western Europe
Authors: Szabó Zsolt 
Published: May 2022

AbstractA common feature of the present-day constitutions of the Western Balkans is the effort to solve conflicts of ethnic character using predominantly legal tools, mostly in a parliamentarian way. However, the practice shows that most legal regimes based on instruments that give preference to the interests of one or more equally strong ethnic groups can be built mostly to the detriment of democratic states. Effective and functional state institutions and ethnic power-sharing in multi-ethnic states seem to be in conflict with each other. Rule-of-law-based models can only function properly if parties have mutual trust and can solve their internal conflicts through compromises among themselves. Political agreements based on mutual trust are more effective in the long term as legal instruments. There are examples of such arrangements in multi-ethnic states of Western Europe (Belgium, Northern Ireland, and Switzerland). Analysis of the solutions of the Western Balkans countries and their comparison with these Western examples shows clearly that hard legal tools (vetoes) do not soften but sharpen conflicts, while informal arrangements based on mutual trust are more productive.