bluuebunny/crossref_metadata_2025_split huggingface dataset:
A reconsideration of university gap funds for promoting biomedical entrepreneurship
Authors: Hall Everett G. , Krenning Thomas M. , Reardon Robert J. , Toker Emre , Kinch Michael S. 
Published: January 2022

Abstract
The last 50 years have seen an increasing dependence on academic institutions to develop and commercialize new biomedical innovations, a responsibility for which many universities are ill-equipped. To address this need, we created LEAP, an asset development and gap fund program at Washington University in St. Louis (WUSTL). Beyond awarding funds to promising projects, this program aimed to promote a culture of academic entrepreneurship, and thus improve WUSTL technology transfer, by providing university inventors with individualized consulting and industry expert feedback. The purpose of this work is to document the structure of the LEAP program and evaluate its impact on the WUSTL entrepreneurial ecosystem. Our analysis utilizes program data, participant surveys, and WUSTL technology transfer office records to demonstrate that LEAP consistently attracted new investigators and that the training provided by the program was both impactful and highly valued by participants. We also show that an increase in annual WUSTL start-up formation during the years after LEAP was established and implicate the program in this increase. Taken together, our results illustrate that programs like LEAP could serve as a model for other institutions that seek to support academic entrepreneurship initiatives.
FebriDx host response point-of-care testing improves patient triage for coronavirus disease 2019 (COVID-19) in the emergency department
Authors: Mansbridge Christopher T. , Tanner Alex R. , Beard Kate R. , Borca Florina , Phan Hang T.T. , Brendish Nathan J. , Poole Stephen , Hill Christopher , Kiuber Michael , Crouch Robert , Waddington Daniel , Clark Tristan W. 
Published: January 2022

AbstractObjectives:Patients presenting to hospital with suspected coronavirus disease 2019 (COVID-19), based on clinical symptoms, are routinely placed in a cohort together until polymerase chain reaction (PCR) test results are available. This procedure leads to delays in transfers to definitive areas and high nosocomial transmission rates. FebriDx is a finger-prick point-of-care test (PoCT) that detects an antiviral host response and has a high negative predictive value for COVID-19. We sought to determine the clinical impact of using FebriDx for COVID-19 triage in the emergency department (ED).Design:We undertook a retrospective observational study evaluating the real-world clinical impact of FebriDx as part of an ED COVID-19 triage algorithm.Setting:Emergency department of a university teaching hospital.Patients:Patients presenting with symptoms suggestive of COVID-19, placed in a cohort in a ‘high-risk’ area, were tested using FebriDx. Patients without a detectable antiviral host response were then moved to a lower-risk area.Results:Between September 22, 2020, and January 7, 2021, 1,321 patients were tested using FebriDx, and 1,104 (84%) did not have a detectable antiviral host response. Among 1,104 patients, 865 (78%) were moved to a lower-risk area within the ED. The median times spent in a high-risk area were 52 minutes (interquartile range [IQR], 34–92) for FebriDx-negative patients and 203 minutes (IQR, 142–255) for FebriDx-positive patients (difference of −134 minutes; 95% CI, −144 to −122; P < .0001). The negative predictive value of FebriDx for the identification of COVID-19 was 96% (661 of 690; 95% CI, 94%–97%).Conclusions:FebriDx improved the triage of patients with suspected COVID-19 and reduced the time that severe acute respiratory coronavirus virus 2 (SARS-CoV-2) PCR-negative patients spent in a high-risk area alongside SARS-CoV-2–positive patients.
Overpromising Social Welfare Benefits? Electoral Competition and Welfare Politics in Taiwan
Authors: Shim Jaemin 
Published: January 2022

AbstractDrawing insights from legislative, electoral and welfare studies, the article investigates whether and to what extent electoral competition affects incumbent politicians’ overpromising of social welfare benefits. For this, Taiwan is chosen as the case and the article examines the fate of elite-level social welfare legislative proposals in the period between 1992 and 2016. Findings drawn from quantitative bill sponsorship patterns demonstrate that political elites tend to propose failure-prone social welfare bills during election periods. Moreover, this tendency grew even more clearly in tandem with the rising levels of electoral democracy. The article argues that the overpromising of social welfare benefits is likely due to cognitive biases on the voter side allowing politicians to make promises without necessarily facing the negative consequences of under-delivery. The article contributes to the comparative welfare state literature by adding much-needed nuance to the existing debates on the relationship between democratic deepening, electoral competition, and the development of welfare politics.
The sponge pump as a morphological character in the fossil record
Authors: Aragonés Suarez Pablo , Leys Sally P. 
Published: January 2022

AbstractThe timing of early animal evolution remains one of the biggest conundrums in biology. Molecular data suggest Porifera diverged from the metazoan lineage some 800 Ma to 650 Ma, which contrasts with the earliest widely accepted fossils of sponges at 535 Ma. However, the lack of criteria by which to recognize the earliest animals in the fossil record presents a challenge. The sponge body plan is unchanged since the early Cambrian, which makes a sponge-type animal a good candidate for the earliest fossils. Here we propose a method for identifying an organism as sponge grade by translating the sponge pump character into a quantifiable morphological trait. We show that the ratio between the two major components of the aquiferous system, the cross-sectional area of the osculum (OSA) and the surface area of the whole sponge (SA), is an effective metric of the pump character of extant sponges and that the slope of this ratio is distinct for three classes of Porifera: Demospongiae, Calcarea, and Hexactinellida. Furthermore, this metric is effective at distinguishing as sponges both extant taxa and fossils from two extremes of the Phanerozoic, the Cambrian and Paleogene. We tested this metric on the putative Ediacaran spongeThectardis avalonensisfrom Mistaken Point, Newfoundland, and foundThectardisfits both with Cambrian sponges and with modern demosponges. These analyses show that the OSA/SA ratio is a reliable character by which to identify fossils as sponge grade, opening up exciting possibilities for classifying new fossils as sponges.
Energy Requirements Undermine Substrate Independence and Mind-Body Functionalism
Authors: Thagard Paul 
Published: January 2022

AbstractSubstrate independence and mind-body functionalism claim that thinking does not depend on any particular kind of physical implementation. But real-world information processing depends on energy, and energy depends on material substrates. Biological evidence for these claims comes from ecology and neuroscience, while computational evidence comes from neuromorphic computing and deep learning. Attention to energy requirements undermines the use of substrate independence to support claims about the feasibility of artificial intelligence, the moral standing of robots, the possibility that we may be living in a computer simulation, the plausibility of transferring minds into computers, and the autonomy of psychology from neuroscience.
Does Neuroplasticity Support the Hypothesis of Multiple Realizability?
Authors: Maimon Amber , Hemmo Meir 
Published: January 2022

AbstractIt is commonly maintained that neuroplastic mechanisms in the brain provide empirical support for the hypothesis of multiple realizability. We show in various case studies that neuroplasticity stems from preexisting mechanisms and processes inherent in the neural (or biochemical) structure of the brain. We argue that not only does neuroplasticity fail to provide empirical evidence of multiple realization, its inability to do so strengthens the mind-body identity theory. Finally, we argue that a recently proposed identity theory called Flat Physicalism can be enlisted to explain the current state of the mind-body problem more adequately.
Islamic State's Terrorist Attacks Disengage Their Supporters: Robust Evidence from Twitter
Authors: Barceló Joan , Labzina Elena 
Published: January 2022

AbstractThis article responds to Hansen's (2022) comment on the use of social media data to evaluate the effects of terrorist attacks on related online behavior. Hansen casts doubts on our previous finding that terrorist attacks disengage supporters of terrorist groups. The author speculates that this result might not hold when considering the bias introduced by the timing of Twitter account suspensions. We contend that this critique is deficient in several respects. First, Hansen speculates about a possible bias, yet no empirical evidence is offered to support this claim. Second, the author largely ignores our discussion of the role of Twitter account suspensions and our measures of Twitter suspension efforts and Anonymous reporting activity to alleviate this concern. In this article, rather than engaging in a qualitative debate on the amount of bias, we make two contributions. First, we offer an empirical investigation of the fragility of our previous finding to the presence of omitted variable bias. Once we account for Twitter suspension activities, we find that an extreme, unlikely amount of confounding is required to alter the estimated effect of terrorist attacks on disengagement. Second, we employ sequential g-estimation to calculate the average controlled direct effect of terrorist attacks on disengagement after controlling for two intermediate confounders: Twitter suspension behavior and Anonymous reporting activities. The estimated average controlled direct effect indicates that Islamic State's terrorist attacks significantly reduced followers in Islamic State-related Twitter accounts after de-mediating this effect from Twitter suspension efforts and Anonymous reporting activities. Further, we show that this average controlled direct effect is robust to a massive, and implausible, violation of the sequential unconfoundedness assumption. Overall, these analyses show that the timing of Twitter account suspensions, as well as any other confounder, is extremely unlikely to alter our conclusion: Islamic State's terrorist attacks disengage their supporters. We conclude this article by offering guidance on how to address practical challenges in political science research using social media data.
The use of modified Montgomery T-tubes as frontal sinus stents: how I do it
Authors: Bandino F , Bates J , Qureishi A , Martinez-Devesa P 
Published: January 2022

AbstractBackgroundFrontal sinus surgery is challenging as the frontal recess is prone to re-stenosis and there is subsequent occlusion of the frontal sinus outflow tract. In an attempt to maintain the frontal recess calibre and reduce frontal sinus re-stenosis, frontal sinus stents have been used with different materials and varying results.ObjectiveThis paper presents the technique of using a modified Montgomery T-tube as a frontal sinus stent.Results and conclusionThe use of a soft, self-retaining and non-absorbable stent that can be used for stenting of the frontal sinus is described. Our technique is safe, effective, inexpensive and well tolerated.
Corporate Governance with Chinese Characteristics: Party Organization in State-owned Enterprises
Authors: Beck Kasper Ingeman , Brødsgaard Kjeld Erik 
Published: January 2022

AbstractThis article analyses the role of the Chinese Communist Party (CCP) in the corporate governance of Chinese state-owned enterprises (SOEs), including a case study of a central-level SOE holding group. Relying on official documents, secondary literature and interviews with enterprise managers, government officials and academics, the article documents how the CCP has actively formalized its role in Chinese business by embedding itself in the corporate governance structure of SOEs. Through the application of Chinese indigenous administrative corporate governance concepts such as “bidirectional entry, cross appointment” and “three majors, one big,” the CCP has consolidated its dominance of enterprise decision-making procedures and personnel appointment and created a hybrid, Party-led model of corporate governance. While this hybrid model can secure enterprise compliance, communication with higher state and Party organs, as well as long-term development planning, it is unlikely to help solve SOE efficiency problems and may even undermine other SOE reforms.
Supraventricular tachycardia associated with severe diabetic ketoacidosis in a child with new-onset type 1 diabetes mellitus
Authors: Shati Ayed A. , Al-Asmari Own J. , Alhayani Abdullah A. , Alqahtani Youssef A. , Alshehri Salem A. , Alhelali Ibrahim A. 
Published: January 2022

AbstractDiabetic ketoacidosis is one of the most serious and common complications of diabetes, with between 15 and 70% of new-onset type 1 diabetes mellitus worldwide presented with diabetic ketoacidosis. Supraventricular tachycardia, however, is an infrequent complication of diabetic ketoacidosis. We present the case of a child with a new-onset type 1 diabetes mellitus with supraventricular tachycardia as a complication of paediatric diabetic ketoacidosis. The patient received intravenous fluid resuscitation, insulin, and potassium supplementation and subsequently developed stable supraventricular tachycardia initially, confirmed on a 12-lead electrocardiogram despite a structurally normal heart and normal electrolytes. Vagal manoeuvers failed to achieve sinus rhythm. The patient went into respiratory distress and was intubated, for mechanical ventilation. She received one dose of adenosine with successful conversion to sinus rhythm and a heart rate decreased from 200 to 140 beats per minutes. We conclude that supraventricular tachycardia can occur as a complication of diabetic ketoacidosis, including in new-onset type 1 diabetes mellitus. Furthermore, a combination of acidosis, potassium derangement, falling magnesium, and phosphate levels may have precipitated the event. Here, we report a case of supraventricular tachycardia as a complication of paediatric diabetic ketoacidosis.
A Counter-Terrorism Medicine Analysis of Drone Attacks
Authors: Barten Dennis G. , Tin Derrick , De Cauwer Harald , Ciottone Robert G. , Ciottone Gregory R. 
Published: January 2022

AbstractBackground:The rapid popularization of unmanned aerial vehicles (UAVs; also referred to as drones), in both the recreational and industrial sectors, has paved the way for rapid developments in drone capabilities. Although the threat of UAVs used by terrorists has been recognized by specialists in both Counter-Terrorism and Counter-Terrorism Medicine (CTM), there are limited data on the extent and characteristics of drone use by terrorist organizations.Methods:Data collection was performed using a retrospective database search through the Global Terrorism Database (GTD). The GTD was searched using the internal database search functions for all terrorist attacks using UAVs from January 1, 1970 - December 31, 2019. Years 2020 and 2021 were not yet available at the time of the study. Primary weapon type, number and type of UAVs used, related attacks, location (country, world region), and number of deaths and injuries were collated. Results were exported into an Excel spreadsheet (Microsoft Corp.; Redmond, Washington USA) for analysis.Results:There were 76 terrorist attacks using UAVs. The first attack occurred in 2016, and the number of attacks per year varied considerably (range: 4-36). Forty-seven of the 76 attacks (70%) were successful. Twenty-seven individually listed events (36%) were related and part of nine coordinated, multi-part incidents. A total of 50 deaths and 132 injuries were recorded, which equated to 1.09 deaths (range: 0-6) and 2.89 injuries (range: 0-20) per successful attack. The mean number of UAVs used in an attack was 1.28 (range: 1-5) and multiple UAVs were used in 22% of attacks.Conclusion:The use of UAVs to carry out terrorist attacks is on the rise. Seventy-six terrorist attacks using this novel method were recorded since 2016, killing 50 and injuring 132 people. While the use of UAV-related explosives appears less lethal than traditional explosive attacks, advancing technologies and swarming capabilities, increasing ability to carry larger payloads, and the possibility of UAVs to disperse chemical, biological, radiological, and nuclear (CBRN) weapons will likely increase UAV lethality in the future, requiring CTM specialists be more proactive.
The challenge of making climate adaptation profitable for farmers: evidence from Sri Lanka's rice sector
Authors: Scognamillo Antonio , Sitko Nicholas , Bandara Sidath , Hewage Shantha , Munaweera Thilani , Kwon Jihae 
Published: January 2022

AbstractAdapting agricultural systems to changes in seasonal precipitation is critical for the agricultural sector in Sri Lanka. This paper presents evidence on the adoption drivers and the welfare impacts of agricultural strategies adopted by Sri Lankan rice farmers to adapt to low rainfall conditions. We estimate the causal impact of adopting different adaptive strategies across three different dimensions: (a) sensitivity to water stress, (b) household productivity, and (c) household livelihood conditions. The results highlight important trade-offs faced by farmers between reducing vulnerability to water stress and maximizing profitability and welfare outcomes. These findings are important for informing policies to support climate adaptation among smallholders, and to build and improve the climate resilience of Sri Lanka's rice sector.
Diagnostic accuracy of the Patient Health Questionnaire 2 (PHQ-2) in Qatar’s primary care settings
Authors: Sedeeq Saad Thamer , AlTamimi Mohammad Jamil Mohammad , Hamed Ehab , Syed Mohamed Ahmed 
Published: January 2022

Abstract
This cross-sectional study was designed to establish diagnostic accuracy of the Patient Health Questionnaire 2 in Qatar’s primary care population. The data required for the study were anonymously extracted from Qatar’s primary care electronic medical record system. The sensitivity, specificity, predictive values, negative values and optimal cut-off points were calculated for the tool. A total of 6921 individuals met the study’s inclusion criteria. The diagnostic accuracy of cut-off values was calculated for scores 1–6. Based on the Youden’s index (0.58), a score of 2 was identified as the most optimal cut-off. It offers a sensitivity of 88.73% and specificity of 69.31%. Further studies should aim to confirm the results using alternative study designs and to report them in accordance to population characteristics both in Qatar and internationally.
Recent Advances in Gas Injection System-Free Cryo-FIB Lift-Out Transfer for Cryo-Electron Tomography of Multicellular Organisms and Tissues
Authors: Klumpe Sven , Kuba Jakub , Schioetz Oda H. , Erdmann Philipp S. , Rigort Alexander , Plitzko Jürgen M. 
Published: January 2022

Abstract:Cryo-electron tomography (cryo-ET) enables visualization of protein complexes within their native cellular environment at molecular resolution. Most cells and all tissues, however, are too thick to be imaged directly by transmission electron microscopy (TEM). Overcoming this limitation requires the production of thin biological sections called lamellae. The procedure to obtain lamellae of cells, either seeded or grown directly on electron microscopy grids, requires cryo-focused ion beam (cryo-FIB) milling to thin the samples. This method faces an additional challenge when dealing with tissues and multicellular organisms, as these samples must be high-pressure frozen, which embeds the sample in a thick layer of ice. Nonetheless, lamellae can still be prepared from such samples by extracting a small volume and transferring it to a receiver grid for lamella preparation, a process called lift-out. Here, we describe the available workflows to produce lamellae by lift-out at cryogenic conditions and recent developments in gas injection system (GIS)-free approaches to the lift-out transfer. These advances expand the applications of cryo-ET, enabling the investigation of tissues and whole organisms in situ at molecular resolution.
Differences in Radiative Forcing, Not Sensitivity, Explain Differences in Summertime Land Temperature Variance Change Between CMIP5 and CMIP6
Authors: Chan Duo , Rigden Angela , Proctor Jonathan , Chan Pak Wah , Huybers Peter 
Published: January 2022

AbstractHow summertime temperature variability will change with warming has important implications for climate adaptation and mitigation. CMIP5 simulations indicate a compound risk of extreme hot temperatures in western Europe from both warming and increasing temperature variance. CMIP6 simulations, however, indicate only a moderate increase in temperature variance that does not covary with warming. To explore this intergenerational discrepancy in CMIP results, we decompose changes in monthly temperature variance into those arising from changes in sensitivity to forcing and changes in forcing variance. Across models, sensitivity increases with local warming in both CMIP5 and CMIP6 at an average rate of 5.7 ([3.7, 7.9]; 95% c.i.) × 10−3°C per W m−2 per °C warming. We use a simple model of moist surface energetics to explain increased sensitivity as a consequence of greater atmospheric demand (∼70%) and drier soil (∼40%) that is partially offset by the Planck feedback (∼−10%). Conversely, forcing variance is stable in CMIP5 but decreases with warming in CMIP6 at an average rate of −21 ([−28, −15]; 95% c.i.) W2 m−4 per °C warming. We examine scaling relationships with mean cloud fraction and find that mean forcing variance decreases with decreasing cloud fraction at twice the rate in CMIP6 than CMIP5. The stability of CMIP6 temperature variance is, thus, a consequence of offsetting changes in sensitivity and forcing variance. Further work to determine which models and generations of CMIP simulations better represent changes in cloud radiative forcing is important for assessing risks associated with increased temperature variance.
Population Exposure Projections to Intensified Summer Heat
Authors: Park Chang‐Eui , Jeong Sujong 
Published: January 2022

AbstractPopulation aging, an increasing share of the elderly to the total population, can exacerbate heat vulnerability to intensified heat hazards. However, the aging impacts on increases in exposure of the elderly to unprecedented hot summers (UHSs) could be variable in the warming climate. Here, we present considerable contribution of age structure changes to increases in the elders' exposure to intensified UHSs in countries with a high percentage of youth population, namely, China, India, and Brazil, by analyzing combined scenarios of climate change with population structure. In the aforementioned regions, increases in exposure to stronger UHSs relevant to rapid aging will exceed at least half of the warming impact, which primarily causes frequent occurrence of stronger UHSs. Conversely, the United States and Europe, which have already entered an aged society, show a negligible aging impact. These results suggest that the future evolution of a society's age structure is an important constraint for projecting population exposure to strengthened summer heat.