bluuebunny/crossref_metadata_2025_split huggingface dataset:
Further development of the Affordances for Motor Behavior of Schoolchildren (AMBS): standardized version and scoring system
Authors: Flôres Fábio Saraiva , Rodrigues Luis Paulo , Cordovil Rita 
Published: May 2022

Abstract
Mapping and evaluating regular contexts that schoolchildren attend is of great importance to understanding motor behavior. This communication aims to present the scoring system and standardization of the Affordances for Motor Behavior of Schoolchildren (AMBS), recently presented to the scientific and educational community. The AMBS was developed to assess children’s interdependent systems, such as home, school, and sports activities, that can influence 6 to 10-year-olds ’ motor development, motor learning, and motor competence. The questionnaire was completed by 377 Brazilian families. Raw scores of each of the three sub-scales (Home, Materials, and School) can be transformed into standard scores, ranging from very low to very high. The AMBS total raw score is a result of the sum of the three sub-scales standard scores and can be classified into three categories, ranging from a low to a high AMBS. We expect that raw and standard scores of the AMBS can be used by researchers, parents, and clinical/education professionals to assess children’s affordances for motor behavior.
Olverembatinib (HQP1351), a highly safe and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial
Authors: Jiang Qian , Li Zongru , Qin Yazhen , Li Weiming , Xu Na , Liu Bingcheng , Zhang Yanli , Meng Li , Zhu Huanling , Du Xin , Chen Suning , Liang Yang , Hu Yu , Liu Xiaoli , Song Yongping , Men Lichuang , Chen Zi , Niu Qian , Wang Hengbang , Lu Ming , Zhai Yifan , Yang Dajun , Huang Xiaojun 
Published: May 2022

Abstract
Background BCR-ABL1T315I mutations confer resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML). Olverembatinib is a new potent BCR-ABL1 TKI with preclinical activity against T315I-mutated CML. In phase 1/2 studies, we explored the safety and efficacy of olverembatinib in Chinese adults with TKI-resistant CML in the chronic phase (CML-CP) and accelerated phase (CML-AP).Methods In the phase 1 study, olverembatinib was orally administered once every other day in 28-day cycles at 11 dose cohorts ranging from 1 to 60 mg, and we evaluated the maximum tolerated dose, recommended phase 2 dose (RP2D), safety, efficacy, and pharmacokinetics of olverembatinib. In the phase 2 studies, olverembatinib was administered at the RP2D of 40 mg orally on alternate days for 28-day cycles. The primary outcome measure is major cytogenetic response (MCyR) and major hematologic response by the end of Cycle 12 in CML-CP and CML-AP, respectively. Fine and Gray's hazard models were used to identify covariates associated with responses. ResultsA total of 165 patients (> 80.0% of whom had received ≥ 2 TKIs) were enrolled in this study. Among 127 patients with CML-CP, the 3-year cumulative incidences of achieving MCyR, complete cytogenetic response (CCyR), major molecular response (MMR), MR4.0, and MR4.5 were 79.0%, 69.0%, 56.0%, 44.0%, and 39.0%, respectively. The highest response rates were observed in patients with a single T315I mutation. Among 38 patients with CML-AP, the 3-year cumulative incidences of achieving MCyR, CCyR, MMR, MR4.0, and MR4.5 were 47.4%, 47.4%, 44.7%, 39.3%, and 32.1%, respectively. In multivariate analyses, baseline BCR-ABL1 mutation status was significantly associated with cytogenetic and molecular responses. Common treatment-related adverse events included skin hyperpigmentation, hypertriglyceridemia, proteinuria, and severe thrombocytopenia.Conclusions Olverembatinib was well tolerated, with significant antileukemic activity in adults with TKI-resistant CML-CP and CML-AP, especially those with the T315I mutation.Trial registration The phase 1 trial is registered at CTR20220566, and the two single-arm, open-label phase 2 studies are registered at ClinicalTrials.gov: NCT03883087 (CML-CP) and NCT03883100 (CML-AP).
3D Bi-layered hydrogel and nanofiber multifunctional sponge dressing: an efficacious healing agent for chronic and deep open wounds
Authors: K Nanditha C. , Shah Manan Rakesh , Priya P , Harikrishnan K , Kumar G. S.Vinod 
Published: May 2022

Abstract
Chronic wound management using biomaterials-based dressings have made a significant impact on improving the standard and efficiency of wound healing. However, various available wound healing aids are ineffective in treating deep open injuries and chronic wounds like diabetic wounds. This study developed a 3D bi-layered hydrogel and nanofiber multifunctional sponge, which addresses the structural and functional issues faced by biomaterial dressings in treating deep and chronic wounds. The layered sponge consists of a hydrogel base functionalised with wound healing peptide carrying nanoparticles and topped with nanofiber layer functionalised with antimicrobial peptide. The 3D bi-layered sponge with its highly porous, elastic and enhanced fluid absorption ability makes it a suitable wound treatment aid. The developed multifunctional 3D-sponge shows antibacterial action and promotes a micro-environment similar to the Extra Cellular Matrix (ECM) in regulating dermal cell survival and migration. Study in full-thickness skin defect diabetic mouse model has shown that developed 3D bi-layered sponge accelerates wound closure and promotes functional skin regeneration. Enhanced diabetic wound healing through reduced inflammation, faster granulation tissue formation, re-epithelialisation, neo-vascularisation, and skin appendage restoration make this 3D bi-layered multifunctional sponge an efficient and advanced chronic wound management aid with potential for future clinical application.
Chia (Salvia hispanica L.) seeds contain a highly stable trypsin inhibitor with potential for bacterial management alone or in drug combination therapy with oxacillin
Authors: de Souza Adson Ávila , Lima Adrianne Maia , de Sousa Daniele de Oliveira Bezerra , Nogueira Francisca Cristiane , Neto José Carlos do Sacramento , Dias Lucas Pinheiro , Araújo Nadine Monteiro Salgueiro , Nagano Celso Shiniti , Júnior Hélio Vitoriano Nobre , Silva Cecília Rocha da , Sá Lívia Gurgel do Amaral Valente , Neto João Batista Andrade , Barroso Fátima Daiana Dias , de Moraes Maria Elisabete Amaral , de Oliveira Hermógenes David 
Published: May 2022

Abstract
The emergence of antibiotic resistance poses a serious and challenging threat to healthcare systems, making it imperative to discover novel therapeutic options. This work reports the isolation and characterization of a thermostable trypsin inhibitor from chia (Salvia hispanica L.) seeds, with antibacterial activity against Staphylococcus aureus sensitive and resistant to methicillin. The trypsin inhibitor ShTI was purified from chia seeds through crude extract heat treatment, followed by affinity and reversed-phase chromatography. Tricine-SDS–PAGE revealed a single glycoprotein band of ~11 kDa under nonreducing conditions, confirmed by mass spectrometry analysis (11.558 kDa). ShTI was remarkably stable under high temperatures (100 °C; 120 min.) and a broad pH range (2 – 10; 30 min.). Upon exposure to DTT (0.1 M; 120 min.), ShTI antitrypsin activity was partially lost (~ 38%), indicating the participation of disulfide bridges in its structure. ShTI is a competitive inhibitor (Ki = 1.79 x 10-8 M; IC50 = 1.74 x 10-8 M) that forms a 1:1 stoichiometry ratio for the ShTI: trypsin complex. ShTI displayed antibacterial activity alone (MICs range from 15.83 to 19.03 µM) and in drug combination with oxacillin (FICI range from 0.20 to 0.33) against strains of S. aureus, including methicillin-resistant strains. Overproduction of reactive oxygen species and plasma membrane pore formation are involved in the antibacterial action mode of ShTI. Overall, ShTI represents a novel candidate for use as a therapeutic agent for the bacterial management of S. aureus infections.
Cross-cultural adaptation and validation of the Thai version of the Functional Index for Hand Osteoarthritis (FIHOA)
Authors: Suwannaphisit Sitthiphong , Tangtrakulwanich Boonsin , Suwanno Porames , Sinnathakorn Nitiphoom , Maheu Emmanuel 
Published: May 2022

Abstract
Background: The Functional Index for Hand Osteoarthritis (FIHOA) is a simple tool to assess functional impairment for hand OA patients. The purpose of this study was to translate the FIHOA into the Thai language, and validate it in Thai hand OA patients.Methods: The FIHOA was translated into Thai (T-FIHOA) according to the principles of cross-cultural adaptation and administered to 102 hand OA patients recruited between September 2020 and July 2021 together with the modified Health Assessment Questionnaire (mHAQ), Disabilities of the Arm, Shoulder and Hand (DASH), and visual analogue scale (VAS) for hand pain. Spearman’s correlation coefficient and intraclass correlation coefficient (ICC) were used to check the test-retest reliability of each item and the total scores in the translated questionnaire. The internal consistency reliability was evaluated using Cronbach’s alpha. The external construct validity was assessed using correlations between the T-FIHOA, mHAQ, DASH and hand pain VAS. Results: The T-FIHOA had a unidimensional structure. The ICC was > 0.9 and the Cronbach’s alpha of 0.92 indicated excellent reliability and internal consistency, respectively. The external validity tests indicated moderate correlation with the hand pain VAS (r = 0.37, P < 0.01) and moderate to strong correlations with the mHAQ (r = 0.63, P < 0.01), and DASH score (r = 0.52, P < 0.01). The T-FIHOA had the highest ES and SRM (- 0.37 and -0.58 respectively) among all questionnaires except for the VAS when assessing changes between baseline and week 4.Conclusions: The T-FIHOA is a good and reliable assessment tool freely available for practitioners/researchers to evaluate functional impairment in Thai hand OA patients.
Viral Inhibitory potential of Hyoscyamine in Japanese Encephalitis virus infected Embryonated Chick involving multiple signaling pathways
Authors: Bhattacharjee Arghyadeep , Naga Rahul , SAHA MANISH , ROY SOUVIK 
Published: May 2022

Abstract
Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis worldwide. Emergence of new genotypes of the virus and increased rate of mutation demands for alternatives that can fight against this deadly pathogen. Although the anti-viral property of Atropa belladonna and its active components such as Atropine, Scopolamine has been studied, yet the role of its another important component hyoscyamine against JEV has not yet been established till date. Thus our current study is focussed to investigate the protective effects of hyoscyamine against JEV and its immunomodulatory function in embryonated chick. Pre-treatment with hyoscyamine sulphate indicated significant decrease in viral load in both CAM and brain tissues after 48 hour and 96 hour (post infection). Insilico studies showed stable binding and interaction between hyoscyamine and NS5 (non structural protein 5) making it an effective compound against the virus. Embryonated eggs pre-treated with hyoscyamine sulphate showed upregulation of TLR3, TLR7, TLR8, IL-4, IL-10 as well as interferons and the regulatory factors. Hyoscyamine sulphate caused significant downregulation of TLR4 as compared to other experimental groups as analysed by one-way ANOVA. Hence our study demonstrated the protective function of hyoscyamine in controlling JEV viral replication and its dissemination to brain that may emerge as a promising therapy against JEV in future.
Tailored Magnetic Properties of a Double Tetrahedral Molecule with Mixed (1, ½) Spin
Authors: Hafidi Mohamed El , Bakas Said Id 
Published: May 2022

Abstract
In this paper, we study the magnetic properties of a molecule composed of two inverted spin-½ tetrahedra sharing their common vertex via a spin-1. We achieve an exact resolution using the Heisenberg model. As long as the exchange couplings are predominantly ferromagnetic, the spin structure is fully saturated and behaves like a large spin-4 unique magnet. Antiferromagnetic coupling can strongly frustrate the spins of the nanodevice. This may lead to several exotic phenomena. Therefore, the magnetization can be quantified into plateaus separated by quantum phase transitions. The work is intended to inspire researchers to develop molecular magnets as a basis for innovative nanoscale engineering applications.
On Asymptotic Behavior of a Bi-jensen Functiona Equation
Authors: Bae Jae-Hyeong , Tareeghee Mohammad Amin , Najati Abbas 
Published: May 2022

Abstract
See manuscript PDF for complete Abstract:In this paper, we give some properties of the bi-Jensen functional equation \[4f\left(\frac{x+y}{2}, \frac{z+w}{2}\right)=f(x,z)+ f(x,w)+ f(y,z)+ f(y,w)\] and the Hyers-Ulam stability is investigated. Also, we establish the Hyers-Ulam stability of the bi-Jensen functional equation on some restricted domains. Finally, we apply the obtained results to study some of interesting asymptotic behaviors of bi-Jensen functions.
Spectroscopic characterization, virtual drug designing, quantum and optoelectronics properties of Schiff base metal (II) complexes
Authors: Choudhary Mukesh , . Aprajita 
Published: May 2022

Abstract
This work is concerned with a combined approach to study the design of three transition metal complexes (platinum (II)/, copper (II)/ and nickel (II)) of 1-(E-(2, 4-dibromophenylimino) methyl) naphthalene-2-ol (HL) ligand, which were virtually designed in silico evaluation as efficient candidates for drug discovery applications. The mono deprotonated (L) ligand act as a bidentate coordinated to transition metal ions through the N and O donor atoms. The studied complexes have been physico-chemically characterized. The structure of the metal (II) complexes analysed through spectral data showed four coordinated tetrahedral complexes with 1:2 (metal: ligand) stoichiometry. The values of quantum yield and fluorescence intensity of metal (II) complexes were found to be more in comparison to HL. The preliminary tests were also conducted and reported in the theoretical biological activities. The photophysical and optical properties of the titled complexes was also incorporated in the study. Furthermore, the quantum computational methods are used for the calculation of linear polarizability, nonlinear optical polarizability, which shows the synthesized complexes as effective NLO materials. Frontier molecular orbitals, total density of state and partial density of state are also studied. Thus, we hope that the present study will provoke not only the interest of material chemists in materials designing but also incite the drug designing community within the medicinal chemistry.
Equity – performance trade-off in water rationing regimes with domestic storage
Authors: Randeniya Aruna , Radhakrishnan Mohanasundar , Sirisena T. A. J. G. , Masih Ilyas , Pathirana Assela 
Published: May 2022

Abstract
Water rationing contributes to inequalities in the water supply. Household storage tanks complicate the performance and the hydraulic modelling of these systems. Rationing is often not based on insights into system performance and fails to achieve equity and the operators struggle to explain the rationing tactics to the stakeholders. Understanding the behaviour of water networks rationed regularly is essential to resolve the supply inequalities. We present a contextual analytical framework for understanding and managing water rationing based on the duration of supply (cycle time), rationing fraction (duration of non-supply) and domestic storage to analyse the equity and performance in the water network. The framework was tested using a model of a distribution network in Kakkapalliya, Sri Lanka, under different rationing schemes. The results show that large household tanks create inequities, which can be reduced through a trade-off by increasing the cycle-time of the rationing with a minor reduction in performance. Very small or non-existent domestic storage also negatively impacts the performance and equity of stressed water networks. Resolution of supply inequalities can be achieved through the trade-off between equity and performance is possible through the operation of the water network and by the regulation of domestic storage in water rationing regimes.
Microplastics in drinking water: a macro issue
Authors: Singh Surya , Trushna Tanwi , Kalyanasundaram Madhanraj , Tamhankar Ashok J. , Diwan Vishal 
Published: May 2022

AbstractMicroplastics are one of the emerging contaminants that have received attention in recent decades due to their adverse effects on human health and the environment. Though microplastics are primarily found in abundance in oceans, freshwater sources and drinking water are not unaffected. Nevertheless, it is not only the microplastics that are harmful; rather their ability to transport contaminants is another serious issue of concern. The contaminant transport ability is affected by various environmental and physico-chemical parameters of microplastics. Lack of effective and targeted water treatment technologies have led intake of microplastics by humans resulting in a variety of health issues. Even though a few regulatory attempts have been made in the direction of curtailing the production and use of microplastics, there is still a long way to go. This paper focuses on various aspects of microplastics’ presence in drinking water, focusing on their contaminant transport ability, human health risks, removal technologies, and the global scenario of concern.
Los espacios escolares transformados: Narrativas y dibujos sobre la experiencia escolar en pandemia
Authors: Dussel Inés , Páez Triviño Yuri Constanza 
Published: May 2022

Este artículo analiza las transformaciones del espacio escolar durante la pandemia de COVID-19 en algunas escuelas mexicanas, a partir de entrevistas a directores y docentes de ocho entidades federativas y de relatos y dibujos de estudiantes de primaria y secundaria. Se plantean algunas reflexiones conceptuales sobre el espacio y la materialidad escolares, en relación con las narrativas y representaciones visuales de la experiencia escolar reciente. Se señala la importancia del ámbito escolar como espacio de lo público y como espacio otro, de umbral y pasaje, rasgos que han perdido especificidad y potencia en el contexto de la pandemia.
Aplicaciones terapéuticas del eculizumab
Authors: Campos-González Natalia , Ruiz-Jiménez Susana , Rodríguez-Jiménez Johanna , Chacón-Jiménez Luz 
Published: May 2022

Introducción: El eculizumab es un anticuerpo monoclonal de tipo IgG diseñado para el tratamiento de la hemoglobinuria paroxística nocturna (HPN), en el que su diana farmacológica forma parte del sistema del complemento. Su mecanismo de acción ha permitido implementarlo en el tratamiento de enfermedades huérfanas, como el síndrome urémico hemolítico atípico (SUHa), trastorno del espectro de la neuromielitis óptica (TENMO) y miastenia gravis, cuya incidencia, es baja. Asimismo, es viable en el tratamiento de Guillain Barré y el síndrome antifosfolípido catastrófico (CAPS). Objetivo: Evidenciar aplicaciones terapéuticas del eculizumab y beneficios más significativos en algunos padecimientos. Materiales y métodos: Se realizó búsqueda bibliográfica en el periodo 2010–2021, en bases de datos: Google Scholar, Science Direct, PubMed y Scielo, utilizando como palabra clave “eculizumab”. Posteriormente, se afinó la búsqueda utilizando palabras claves asociadas a enfermedades tratadas con este medicamento. Resultados: Se identificó el mecanismo de acción del fármaco y su efecto sobre la patogénesis de hemoglobinuria paroxística nocturna, síndrome urémico atípico, miastenia gravis generalizada refractaria, trastorno del espectro de la neuromielitis óptica, síndromes antifosfolípidos catastrófico y Guillain-Barré. Conclusiones: El eculizumab tiene una alta seguridad y capacidad para tratar y disminuir síntomas de diversas enfermedades que involucran el sistema del complemento.
Saúde Mental e Interprofissionalidade: experiência de Betim, Minas Gerais, Brasil
Authors: Faria Dirley Lellis dos Santos , Modena Celina Maria , Ferreira Neto João Leite , Silva Kênia Lara 
Published: May 2022

O modelo da Atenção Psicossocial trouxe novas formas de organização do trabalho em saúde mental. O objetivo desse estudo foi compreender a dinâmica de trabalho em equipe multiprofissional desenvolvido nos serviços de Betim/MG. O referencial metodológico se baseou na pesquisa qualitativa. Foram realizadas entrevistas narrativas e grupo focal. Sob a orientação da hermenêutica-dialética, foram construídas três categorias de análise: construção do processo de trabalho - aspectos históricos e atuais; trabalho em equipe e repercussões nas profissões; desafios do trabalho. O trabalho na Saúde Mental tem sido desenvolvido por equipes multidisciplinares, numa proposta de organização interprofissional. Os trabalhadores puderam reconstruir lugares identificatórios distintos de suas categorias específicas. Embora reconheçam que o trabalho em equipe e os dispositivos de reflexão coletiva são essenciais para sustentação do modelo, há desafios que comprometem o cuidado e provocam sofrimento no trabalhador, indicando a necessidade de investimento em Educação Permanente em Saúde.
Feeling with Demons
Authors: Joyce Oscar 
Published: May 2022

Historians of English witchcraft have long recognised that early modern pamphlets provide a rare window into otherwise inaccessible aspects of historical witchcraft cases. Although the factuality of these texts is often difficult to corroborate, they include information and texture beyond that which we can access through surviving procedural trial documentation. The ‘affective turn’ has directed our attention toward the variability and historical significance of emotions and texts such as these pamphlets, which hold tantalising imprints of contemporary feelings. The Witches of Warboys is one such pamphlet, albeit one that has – for a variety of reasons – gone underexamined. In this paper, I present examples from the Warboys case in 1593 in support of two recent propositions about the relationship between witchcraft and emotion. Namely, a witch’s familiars were used as a vector to express intense or suppressed emotions, and people formed fantastical surrogate relationships with these entities. Whereas other studies have tended to concentrate on accused witches themselves, a close reading of the Warboys case reveals it was specifically the bewitched in this instance who formed ambiguous relationships with familiars and projected their emotions through these strange entities.
On the Threshold of Desire
Authors: Venturi Tristan 
Published: May 2022

Christine Battersby describes the aesthetic category of the sublime as "overwhelming [...] terrifying; unrepresentable; revolutionary [while] also slippery, denoting a concept [...] subject to metamorphosis and flux," and resulting in the experience of "surrender or displacement of the ego." A similar definition may be claimed for the notion of queer, a subversive "category in flux" devoted to troubling both subjects and objects by submitting them to the lenses of strangeness and difference, ultimately destabilising regimes of cis-hetero-normativity. How and where do the categories of sublime and queer intersect? What type of cinematic aesthetics stems from their encounter, and what are its resulting social and political implications? This essay attempts to answer such questions through the close textual analysis of two West German productions - Werner Schroeter's Der Rosenkönig (1986) and Ulrike Ottinger's Johanna d'Arc of Mongolia (1989) - and the ways in which both films seek to introduce new canons of visual pleasure by employing highly stylized aesthetic elements symptomatic of a larger, political category of queer sublimity that is found to revolve around the eroticization of boundaries between Self and Other.
Keywords: Ulrike Ottinger; Werner Schroeter; German cinema; queer sublime; queer theory