bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Value of Elevated Pre-treatment Serum CA-125 in Epithelial Ovarian Cancer: A Meta-Analysis
Authors: Wang Qingyi , Feng Xiaoling , Liu Xiaofang , Zhu Siyu 
Published: April 2022

BackgroundCA-125 is a clinical biomarker with predictive effect on the prognosis of different cancers. Numerous clinical trials have been conducted to investigate the possibility of using the pretreatment level of CA-125 to predict the prognosis of epithelial ovarian cancer (EOC). However, its value in predicting prognosis remains controversial. The purpose of this meta-analysis was to assess the predictive value of pretreatment CA-125 levels for prognosis in EOC patients.MethodsWe searched the EMBASE, Cochrane library, PubMed and Web of Science databases for studies published up to 3 December 2021, according to specific inclusion and exclusion criteria. The clinical studies that were included investigated the relationship between pretreatment CA-125 levels and ovarian cancer prognosis. Combined hazard ratios (HR) of overall survival (OS) and progression-free survival (PFS) reported in the studies were compared and analyzed using fixed-effects/random-effects models. Sensitivity analysis was used to assess study stability, while Egger’s and Begg’s tests were used to assess publication bias.ResultsThis meta-analysis included 23 studies published in 2004 - 2021 with a total of 10,594 EOC patients. Comprehensive analysis demonstrated that the serum level of CA-125 before treatment was significantly correlated with overall survival (OS: HR=1.62, 95%CI=1.270-2.060, p&lt;0.001) and progression-free survival (PFS: HR=1.59, PFS: HR=1.59, 95%CI=1.44~1.76, p&lt;0.001). After comparing data from different FIGO stages and treatments, we discovered that a high pre-treatment serum CA-125 level was associated with a low survival rate.ConclusionAccording to the results of this study, a higher pre-treatment serum CA-125 level is associated with poor survival outcomes, which can be utilized to predict the prognosis of EOC patients. Pre-treatment serum CA-125 level might provide reliable basis for predicting the risk of EOC disease progression. This study is registered with the International Prospective Register of Systematic Reviews (CRD42022300545).Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=300545, identifier [CRD42022300545].
Case Report, Practices Survey and Literature Review of an Under-Recognized Pediatric Vascular Disorder: The BASCULE Syndrome
Authors: Baurens Natacha , Briand Clémence , Giovannini-Chami Lisa , De Guillebon De Resnes Jean-Marie , Hubiche Thomas , Chiaverini Christine , Giordana Pascal , Leftheriotis Georges , Bernardor Julie 
Published: April 2022

IntroductionBier anemic spots, cyanosis, and urticaria-like eruption (BASCULE) syndrome is an underreported pediatric vascular disorder from the group of acrosyndromes. In children, these include paroxysmal acrosyndromes (Raynaud’s phenomenon and chilblain-like lesions), permanent acrosyndromes (acrocyanosis), and transient acrosyndromes, in which their pathogeneses are associated with virus infections, Epstein-Barr virus, and, more recently, SARS-CoV-2, respectively.MethodsWe reported a case of BASCULE syndrome associated with postural orthostatic tachycardia syndrome (POTS) and provided a narrative review of case reports describing the BASCULE syndrome in children. Moreover, we presented the results of a prospective practice survey that we performed in the French medical community.ResultsA 14-years-old boy reported pruritic erythrocyanic lesions on the lower limbs, which occurred whenever he was in a standing position and fully resolved when he laid down. He reported asthenia and cramps. He presented a typical BASCULE syndrome associated with POTS confirmed by a tilt-test. Physical and vascular examinations were within the normal range. We identified 12 case reports, describing 21 pediatric cases since 2016. Most patients were adolescents between 12 and 19 years of age or were newborns. Furthermore, 20% of cases in the literature have presented POTS or orthostatic intolerance. Our survey among 95 French physicians confirmed that BASCULE syndrome is an underdiagnosed and under recognized disease in the general pediatric practice, at least in France. Among these physicians, 65% had already encountered patients with similar symptoms, but only 30% declared that they had knowledge of the BASCULE syndrome.ConclusionThe under-recognition of the clinical manifestations leads the patients to consult emergency rooms, with multiple unnecessary investigations performed. Therefore, we suggest that the diagnosis of BASCULE syndrome is based on clinical observations, without the need for laboratory tests, to avoid unnecessary health costs. We suggest physicians to perform a tilt-test when POTS is suspected.
Case Report: Severe Eosinophilic Asthma Associated With ANCA-Negative EGPA in a Young Adult Successfully Treated With Benralizumab
Authors: Ricciardi Luisa , Soler Daniel Griscti , Bennici Alessandra , Brunetto Silvia , Pioggia Giovanni , Gangemi Sebastiano 
Published: April 2022

Background: Traditionally, Eosinophilic Granulomatosis with Polyangiitis (EGPA) has been treated with systemic corticosteroids and immunosuppressants. In recent years, therapeutic efforts have been directed towards targeting eosinophils which represent a major player in the pathogenesis of EGPA. In 2017 the Food and Drug Administration (FDA) approved mepolizumab, a humanized monoclonal antibody targeting interleukin 5 (IL-5) which reduces the production and survival of eosinophils, already used to treat severe eosinophilic asthma, for the management of EGPA. Benralizumab is a humanized monoclonal antibody that targets the IL-5 receptor and is indicated in the treatment of severe eosinophilic asthma.Case description: We describe the case of a young female with a positive history of severe eosinophilic asthma associated with EGPA, treated successfully with benralizumab.
Polymer-Gel Radiation Dosimetry of Laser-Based Relativistic Electron Sources for Biomedical Applications: First Qualitative Results and Experimental Challenges
Authors: Fitilis Ioannis , Grigoriadis Anastasios , Tazes Ioannis , Petrakis Stelios , Andrianaki Georgia , Dimitriou Vasilios , Bakarezos Efthimios , Benis Emmanouil P. , Tsiapa Irini , Boursianis Themistoklis , Kalaitzakis Georgios , Bontzos Georgios , Liakopoulos Dimitrios A. , Pappas Evangelos , Detorakis Efstathios T. , Clark Eugene L. , Maris Thomas G. , Papadogiannis Nektarios A. , Tatarakis Michael 
Published: April 2022

The generation of laser based relativistic electron sources involves impressive basic science as well as innovative applications. This study reports first novel qualitative results on polymer-gel radiation dosimetry of ultrafast laser-based relativistic electron beams. The fabricated polymer-gels are irradiated by the ultra-high dose rate (FLASH) laser-generated electron beams and then are analysed using magnetic resonance imaging. The reading of the irradiated dosimeters is performed using a clinical 1.5 T Magnetic Resonance Imaging system. Three-dimensional colour parametric T2 maps are then constructed from the original PD-T2 weighted images obtained from the clinical MRI scanner. For comparison, the gels are also irradiated with standard electron beams of various energies utilizing a radiotherapy clinical linear accelerator system. For the calibration measurements of the gel dosimetry method, special calibrated dosimetric films are also implemented. The preliminary results demonstrate the potential of polymer gel dosimetry for 3D-dose-distribution of FLASH type irradiation of laser generated electron beams. Furthermore, they illustrate potential issues related to the polymer gel based dosimetry in challenging irradiation arrangements, such as the oxygen sensitivity and necessity for oxygen impermeable container material.
Gratitude Can Help Women At-Risk for Depression Accept Their Depressive Symptoms, Which Leads to Improved Mental Health
Authors: Tomczyk Joanna , Nezlek John B. , Krejtz Izabela 
Published: April 2022

IntroductionGratitude is commonly known as a positive emotion, but it can also be understood as a disposition—one’s inherent quality that includes being grateful for the positive aspects of one’s life and appreciating altruistic gifts. A growing body of research suggests that having a disposition of gratitude is positively related to wellbeing and psychological adjustment. The present study examined the extent to which acceptance of illness—a measure of adjustment to a distressing condition—mediated relationships between dispositional gratitude and wellbeing among women who had elevated levels of depressive symptoms.MethodsParticipants were 131 women who, based on scores on the Center for Epidemiological Studies Depression scale, were at-risk for experiencing clinical depression. Thirty-five of these participants had been diagnosed as depressed at some point in their lives and 96 had not. Participants completed measures of dispositional gratitude, wellbeing, anxiety, and acceptance of illness.ResultsDispositional gratitude was positively correlated with wellbeing and was negatively correlated with depression and anxiety. Dispositional gratitude was also positively correlated with acceptance of illness. Mediational analyses found that acceptance of illness mediated relationships between dispositional gratitude and wellbeing, between dispositional gratitude and anxiety, and between dispositional gratitude and depression. Moreover, such mediation varied as a function of whether women had ever been diagnosed as depressed. Acceptance of illness was related more strongly to wellbeing for women who had been diagnosed as depressed at some time in their lives than it was for women who had never been diagnosed as depressed.ConclusionWomen with elevated depressive symptoms who were more grateful (compared to those who were less grateful) were more accepting of their condition, which was related to increased wellbeing and decreased feelings of depression and anxiety.
Mental State of Inpatients With COVID-19: A Computational Psychiatry Approach
Authors: Sorokin Mikhail Yu. , Palchikova Ekaterina I. , Kibitov Andrey A. , Kasyanov Evgeny D. , Khobeysh Maria A. , Zubova Elena Yu. 
Published: April 2022

BackgroundThe overload of healthcare systems around the world and the danger of infection have limited the ability of researchers to obtain sufficient and reliable data on psychopathology in hospitalized patients with coronavirus disease 2019 (COVID-19). The relationship between severe acute respiratory syndrome with the coronavirus 2 (SARS-CoV-2) infection and specific mental disturbances remains poorly understood.AimTo reveal the possibility of identifying the typology and frequency of psychiatric syndromes associated with acute COVID-19 using cluster analysis of discrete psychopathological phenomena.Materials and MethodsDescriptive data on the mental state of 55 inpatients with COVID-19 were obtained by young-career physicians. Classification of observed clinical phenomena was performed with k-means cluster analysis of variables coded from the main psychopathological symptoms. Dispersion analysis with p level 0.05 was used to reveal the clusters differences in demography, parameters of inflammation, and respiration function collected on the basis of the original medical records.ResultsThree resulting clusters of patients were identified: (1) persons with anxiety; disorders of fluency and tempo of thinking, mood, attention, and motor-volitional sphere; reduced insight; and pessimistic plans for the future (n = 11); (2) persons without psychopathology (n = 37); and (3) persons with disorientation; disorders of memory, attention, fluency, and tempo of thinking; and reduced insight (n = 7). The development of a certain type of impaired mental state was specifically associated with the following: age, lung lesions according to computed tomography, saturation, respiratory rate, C-reactive protein level, and platelet count.ConclusionAnxiety and/or mood disturbances with psychomotor retardation as well as symptoms of impaired consciousness, memory, and insight may be considered as neuropsychiatric manifestations of COVID-19 and should be used for clinical risk assessment.
Latent Profile Analysis to Survey Positive Mental Health and Well-Being: A Pilot Investigation Insight Tunisian Facebook Users
Authors: Guelmami Noomen , Tannoubi Amayra , Chalghaf Nasr , Saidane Mouna , Kong Jude , Puce Luca , Fairouz Azaiez , Bragazzi Nicola Luigi , Alroobaea Roobaea 
Published: April 2022

BackgroundTo examine mental health during COVID-19 peaks, lockdown, and times of curfew, many studies have used the LPA/LCA person-centered approach to uncover and explore unobserved groups. However, the majority of research has focused only on negative psychological concepts to explain mental health. In this paper, we take another perspective to explore mental health. In addition, the study focuses on a period of peak decline in the COVID-19 pandemic.ObjectiveThe present paper aim (a) empirically identifies different profiles among a cohort of Facebook users in Tunisia based on positive factors of mental health using a person-centered approach, (b) outline identified profiles across sociodemographic, internet use, and physical activity, and (c) establish predictors of these profiles.MethodsCross-sectional data were collected through an online survey among 950 Facebook users were female (n = 499; 52.53%) and male (n = 451; 47.47) with an average age =31.30 ± 9.42. Subjects filled Arabic version of Satisfaction with Life Scale, Scale of Happiness (SWLS), Gratitude Questionnaire (GQ-6), International Physical Activity Questionnaire (IPAQ), and the Spirituel Well-Being Scale (SWBS).ResultsThe LPA results revealed three clusters. The first cluster (n = 489, 51,47%) contains individuals who have low scores on the positive psychology scales. The second cluster (n = 357, 37,58%) contained individuals with moderate positive psychology scores. However, a third cluster (n = 104, 10,95%) had high positive psychology scores. The selected variables in the model were put to a comparison test to ensure that the classification solution was adequate. Subsequently, the clusters were compared for the variables of socio-demographics, use of the internet for entertainment and physical activity, the results showed significant differences for gender (low mental well-being for the female gender), socio-economic level (low for the low-income class), and physical activity (low mental well-being for the non-exerciser). However, no significant differences were found for the variables age, location, and use of the Internet for entertainment.ConclusionOur results complement person-centered studies (LPA/LCA) related to the COVID-19 pandemic and can serve researchers and mental health practitioners in both diagnostic and intervention phases for the public. In addition, the GQ6 scale is a valid and reliable tool that can be administered to measure gratitude for culturally similar populations.
Factors Influencing Public Awareness of and Attitudes Toward Palliative Care: A Cross-Sectional Analysis of the 2018 HINTS Data
Authors: Lu Xinyu , Liu Jiawei 
Published: April 2022

BackgroundThe global burden of serious health-related suffering requiring palliative care has been projected to grow significantly by 2060, which indicates the imminent need for integrating palliative care into health systems globally. Moreover, research evidence has been accumulating in support of the earlier adoption of palliative care into the treatment course of serious life-threatening illnesses. However, barriers to earlier access to palliative care still remain, which might be attributable to the global lack of awareness of palliative care and the prevalence of negative perceptions and attitudes. To address this, further investigation of the influencing factors of public perceptions of palliative care is imperative to help inform and develop effective targeted public health campaigns and education messages aimed at improving views of palliative care and thereby early access.MethodsWe used data from the Health Information National Trends Survey (HINTS), a nationally representative cross-sectional survey routinely administrated by the National Cancer Institute from the United States. Specifically, we analyzed the latest palliative care data from HINTS 5 Cycle 2 data set. Sociodemographic characteristics, individual factors such as self-perceived health status, and interpersonal factors such as relationship quality were examined as predictors of public awareness of and attitudes toward palliative care. Survey data were analyzed using SPSS 26 with multiple hierarchical regression tests.ResultsResults showed that people's quality of interpersonal relationships was a significant influencing factor of their awareness of and attitudes toward palliative care. Moreover, cancer diagnosis history and perceived healthcare quality were found to jointly affect their awareness of palliative care; perceived health status and patient centeredness interacted to influence their awareness of and attitudes toward palliative care. Finally, female, non-white, and poorer people were more aware of palliative care, while female and more educated people had more favorable attitudes.ConclusionsThe quality of social relationships emerges as a significant predictor of people's awareness of and attitude toward palliative care, as treatment options and decisions of serious life-threatening illnesses often involve the patients' family. The results hold strong implications for public health campaigns and education messages aiming at changing people's views of palliative care, which ultimately improve end-of-life outcomes.
First Molecular Identification of Three Clinical Isolates of Fungi Causing Mucormycosis in Honduras
Authors: Ortiz Bryan , Laínez-Arteaga Isis , Galindo-Morales Celeste , Acevedo-Almendárez Lilia , Aguilar Kateryn , Valladares Diana , López Miriam , Fontecha Gustavo 
Published: April 2022

Mucormycoses are rare but serious opportunistic fungal infections caused by filamentous organisms of the order Mucorales. Here we report the first molecular identification of Rhizopus oryzae (heterotypic synonym Rhizopus arrhizus), R. delemar, and Apophysomyces ossiformis as the etiological agents of three cases of severe mucormycosis in Honduras. Conventional microbiological cultures were carried out, and DNA was extracted from both clinical samples and axenic cultures. The ITS ribosomal region was amplified and sequenced. Molecular tools are suitable strategies for diagnosing and identifying Mucorales in tissues and cultures, especially in middle-income countries lacking routine diagnostic strategies.
Centimeter-scale laser lift-off of an AlGaN UVB laser diode structure grown on nano-patterned AlN
Authors: Shojiki Kanako , Shimokawa Moe , Iwayama Sho , Omori Tomoya , Teramura Shohei , Yamaguchi Akihiro , Iwaya Motoaki , Takeuchi Tetsuya , Kamiyama Satoshi , Miyake Hideto 
Published: April 2022

Abstract
The centimeter-scale laser lift-off (LLO) of a UVB laser diode structure on nano-patterned AlN was demonstrated by using a 257 nm pulsed laser. The mechanism of this LLO, which can be used for vertical light-emitting device fabrications, was analyzed in detail from the structural and optical properties. The large-area high-yield LLO without cracks was found to be enabled by taking advantage of the intentional in-plane periodic and nanometer-scale inhomogeneous distribution of the AlN molar fraction in the AlGaN layer introduced by growing AlGaN on nano-patterned AlN.
Dimensión humana en los familiares de pacientes hospitalizados
Authors: Botello Reyes Andrea del Pilar , González Mendoza Julio Alfonso , Vergel Ortega Mawency 
Published: April 2022

La espiritualidad es un elemento que cobra especial importancia en cuidado integral que se extiende hacia los familiares de los pacientes en condición crítica. El objetivo de esta investigación es establecer el nivel de bienestar espiritual de los familiares de los pacientes hospitalizados en unidades de cuidado intensivo, para ello se utiliza el método cuantitativo, descriptivo, transversal realizado en las unidades de cuidado intensivo del Hospital Universitario Erasmo Meoz, Colombia, desde diciembre de 2020 hasta julio de 2021. La muestra realizada compuesta por 150 familiares de pacientes hospitalizados, seleccionados por medio de muestreo no probabilístico por conveniencia.
Los principales resultados señalan que Se evidenció predominio del sexo femenino en un 65,3%, del grupo etario entre 36-59 años en un 57,3%, la pareja como tipo de familiar más común con un 42,3%, la religión católica en un 60.6% y el nivel económico de bajo 88,6%. Los niveles de espiritualidad encontrados fueron en los familiares fueron altos en las dimensiones de creencias y prácticas espirituales. Las conclusiones sobre esta investigación se refieren a que en los escenarios de salud donde se cuida a pacientes críticos se debe extender las intervenciones hacia la familia, promoviendo la vivencia y las expresiones de la espiritualidad tanto en las creencias personales, como en las manifestaciones visibles de la experiencia, permitiendo así que desde la perspectiva de enfermería el cuidado brindado sea cada vez más significativo, y alcance una dimensión más trascendental como lo es el abordaje del ser espiritual de cada persona.
Prevalence of chronic noncommunicable diseases and their associated factors in adults over 39 years in riverside population in the Western Brazilian Amazon region
Authors: Antonieta Relvas Pereira  , Juliana Souza de Almeida Aranha Camargo  , Sergio de Almeida Basano  , Aranha Camargo Luís Marcelo 
Published: April 2022

The prevalence of Chronic Noncommunicable Disease (CND) are rocketting over the world, including in young adults. The WHO estimates that more than half of the deaths in the world are caused by CND.
A cross-sectional study was carried out from june to november 2016. The researchers visited 16 communities, with a sample size of 183 adult individuals performed for convenience. The patients went through screening and verified: weight, height, abdominal circumference, blood pressure, clinical-epidemiological history and performed physical and laboratory examination. Prevalence ratios were calculated with confidence intervals of 95% and with statistical significance with p<0.05.
This study aims to estimate the prevalence of CND and its associated factors in the elderly riverside population of the Rio Madeira in Humaitá, Amazonas State, Western Brazilian Amazon.
The prevalence of systemic arterial hypertension (SAH) was 44.7%, 52.6% in female. Of the individuals with SAH, 77.5% did not use medication. About 51.5% of them had Grade I SAH. The prevalence of type 2 diabetes mellitus was 16.4%, where no patient used medication and about 40.4% of the studied population fits in the glucose intolerance range. Metabolic syndrome presented a prevalence of 24.0%, with a higher frequency in females (33.8%) (p=0.007). Concerning chronic kidney disease, a prevalence of 12.1% was observed in both genders. The associated factors found were alcoholism, smoking, sedentary lifestyle and obesity, and more than 45% of the patients had at least two associated factors.
The population had a high prevalence of CND and associated factors, low frequency of medication use, revealing inefficiency of the local health system. Increased coverage of the Governmental Family Health Strategy (GFHS) and the increase in number of trained Community Health Assistants , together with health education actions can increase the population’s health standard.