bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of lactate in out-of-hospital cardiac arrest: a prospective cohort study
Authors: Charlton Karl , Stagg Hayley 
Published: April 2022

Background: The prognostic role of lactate in out-of-hospital cardiac arrest (OHCA) remains unclear. Aims: To explore serum lactate as a predictor of return of spontaneous circulation in patients experiencing OHCA after arrival at hospital. Methods: This 13-month prospective observational cohort study involved patients aged ≥18 years. Serum lactate levels were measured during cardiopulmonary resuscitation before ROSC. Patients were divided into two groups by lactate level: Group 1, low (≤9.9 mmol/l) and Group 2, high (≥10 mmol/l). Findings: 105 patients were included, 50 in group 1 and 55 group 2. Median lactate were 7.4 mmol/l and 14.2 mmol/l respectively. More patients in group 1 were found with ventricular fibrillation (40% versus 14.5%; P≤0.01), obtained ROSC more quickly (37 minutes 38 seconds versus 39 minutes 13 seconds; P=0.79) and achieved short-term survival (survived >24 hours) (40% versus 23.5%; P=0.32), versus group 2; prediction of survival did not reach statistical significance. Conclusion: Lower lactate levels in OHCA appear to be associated with better short-term outcomes but the cut-off points regarding survival remain unclear.
Una estructura neurodidáctica para el desarrollo de las funciones ejecutivas en los adolescentes
Authors: Ramos Regalado Iris , Codina Mònica , Aldana Duby , Piédrola Isabel 
Published: April 2022

Existe un creciente interés por generar prácticas neuroeducativas que pongan el foco en los procesos de aprendizaje de los estudiantes con el fin de poder generar cambios en sus capacidades cognitivas y, por ende, facilitar una mejoría del rendimiento académico.A lo largo de este artículo se presenta una estructura neurodidáctica diseñada para el desarrollo de las funciones ejecutivas (FE) en la etapa adolescente y pensada para ser incorporada en las distintas materias escolares, dado que, si se quiere incidir en las FE, estas deben estar integradas de manera transversal dentro de la competencia aprender a aprender. Para su aplicación, se plantea un estudio dividido en tres fases.Finalmente, se argumenta la necesidad de promover estrategias comunes para la creación de aulas neuroeducativas que desarrollen las funciones ejecutivas, favorezcan el buen desarrollo cognitivo de los adolescentes y aporten un cambio de mirada a los profesionales de la educación sobre el desarrollo y las potencialidades de la mente adolescente.
Extremely narrow resonant linewidths in metal-dielectric heterostructures
Authors: Zheng Jie , Zhu Jinfeng , Yang Zhilin 
Published: April 2022

Plasmonic high-quality factor resonators with narrow surface plasmon resonance (SPR) linewidths are extremely significant for surface-enhanced Raman scattering, optical sensors, imaging, and color filters. Unfortunately, extensive research on narrowing SPR linewidths is mainly based on noble metal nanostructures that are restricted by intrinsic loss. Here, heterostructures consisting of metal and dielectric metaphotonics are experimentally designed and fabricated for elaborating SPR linewidths. The results demonstrate that the SPR linewidths can be narrowed by 66.7% relative to that of aluminum nanostructures. The resonant linewidths are directly shrunk due to the interaction between low loss in the semiconductor nanostructures and electromagnetic confinement in the metal counterparts. Meanwhile, the resonant wavelength governed by heterostructure configurations shifts from 600 to 930 nm. This work will pave an avenue toward controlling resonant linewidths of metal-dielectric heterostructures for numerous applications.
Effects of selenium supplementation on glycemic control markers in healthy rodents: A systematic review protocol
Authors: Ferreira Rannapaula Lawrynhuk Urbano , de Sousa Ângela Waleska Freire , Oliveira Antonio Gouveia , de Rezende Adriana Augusto , Cobucci Ricardo Ney , Pedrosa Lucia Fatima Campos 
Published: April 2022

Background
In vivo and in vitro studies have shown that Se has an insulin-mimetic action associated with its antioxidant activity. Other studies, in turn, suggest that high Se doses and high selenoprotein expression interfere with insulin signaling. This study aims to evaluate the effects of Se supplementation on glycemic control markers in healthy rodents.

Methods
The protocol was developed according to the Preferred Reporting Items for Systematic Review and Metaanalysis Protocol (PRISMA-P) and was published in the International Prospective Register of Systematic Reviews database (PROSPERO; CRD4202121201142019119181). Experimental, randomized, or non-randomized studies of healthy rodents models will be included. All forms of supplemented Se will be considered, including organic, inorganic, and synthetic compounds, selenium-enriched yeasts, zerovalent Se nanoparticles, and selenized polysaccharides. Fasting blood glucose will be considered the primary outcome. Homeostatic model assessment, plasma and erythrocyte Se concentration, GPX activity, SELENOP concentration, and other Se biomarkers will be considered secondary outcomes. EMBASE, Scopus, Pubmed/Medline, Web of Science, and CINAHL will be searched for articles published with no language restrictions. Two reviewers will independently conduct the search and selection of articles, data extraction, and quality analysis. The risk of bias and methodological quality analyses of the included studies will be performed using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) and Collaborative Approach to Meta-Analysis and Review (CAMARADES) tools, respectively. The results will be presented as a narrative synthesis according to the Synthesis Without Meta-analysis (SWiM) Reporting Guideline. Meta-analyses will be conducted where appropriate using random-effects models.

Discussion
The review may clarify the interaction between different forms of supplemented Se and glycemic control in rodents models. The results will provide evidence that will help select doses and forms of Se to administer in clinical trials while according to impact on the glycemic control while elucidating mechanisms of Se metabolism.
Comparison of Montreal cognitive assessment and Mattis dementia rating scale in the preoperative evaluation of subthalamic stimulation in Parkinson’s disease
Authors: Gülke Eileen , Alsalem Mohammad , Kirsten Maja , Vettorazzi Eik , Choe Chi-un , Hidding Ute , Zittel-Dirks Simone , Buhmann Carsten , Schaper Miriam , Gulberti Alessandro , Moll Christian K. E. , Hamel Wolfgang , Koeppen Johannes , Gerloff Christian , Pötter-Nerger Monika 
Published: April 2022

IntroductionThe preoperative evaluation of Parkinson’s Disease (PD) patients for subthalamic nucleus deep brain stimulation (STN-DBS) includes the assessment of the neuropsychological status of the patient. A widely used preoperative test is the Mattis Dementia rating scale (MDRS). However, the Montreal cognitive assessment (MoCA) has also been proven to be a sensitive, time-sparing tool with high diagnostic validity in PD. We evaluate the utility of the MoCA as a preoperative screening test for PD patients undergoing bilateral STN-DBS.MethodsIn this single-centre, retrospective study, we analysed pre- and postoperative assessments of MoCA, MDRS, Movement disorder society-Unified PD Rating Scale-motor examination, PD Questionnaire-39 and levodopa equivalent daily dose. Longitudinal outcome changes were analysed using paired t-test, Pearson’s correlation coefficient, linear regression and CHAID (chi-square automatic interaction detector) regression tree model.ResultsClinical motor and cognitive scores of 59 patients (61.05±7.73 years, 24 females) were analysed. The MoCA, but not the MDRS, identified significant postoperative cognitive decline in PD patients undergoing STN-DBS. The preoperative MoCA score correlated with postoperative quality of life improvement, whereas the MDRS did not. PD patients with a MoCA score ≤ 23 points had a significant decline of quality of life after DBS surgery compared to patients > 23 points.ConclusionThis study identifies the MoCA as an alternative test within the preoperative evaluation of PD patients for the detection of neuropsychological deficits and prediction of the postoperative improvement of quality of life.
Social and professional recognition are key determinants of quality of life at work among night-shift healthcare workers in Paris public hospitals (AP-HP ALADDIN COVID-19 survey)
Authors: Duracinsky Martin , Marcellin Fabienne , Cousin Lorraine , Di Beo Vincent , Mahé Véronique , Rousset-Torrente Olivia , Carrieri Patrizia , Chassany Olivier 
Published: April 2022

Objective
Documenting the perceptions and experiences of frontline healthcare workers during a sanitary crisis is key to reinforce healthcare systems. We identify the determinants of quality of working life (QWL) among night-shift healthcare workers (NSHW) in Paris public hospitals shortly after the first-wave of the COVID-19 pandemic.

Methods
The ALADDIN cross-sectional online survey (15 June to 15 September 2020) collected QWL, socio-economic, behavioral, and work-related information among 1,387 NSHW in the 39 hospitals of the Assistance Publique—Hôpitaux de Paris (AP-HP). Data were weighted (margin calibration) to be representative of the entire population of 12,000 AP-HP hospitals’ NSHW regarding sex, age, and professional category. Linear regression was used to identify correlates of QWL (WRQoL scale).

Results
New night position during the COVID pandemic, difficulties in getting screened for COVID, and considering protective measures inadequate were associated with poorer QWL, after adjustment for socio-economic characteristics, professional category, perceived health, physical activity, and history of harassment at work. Under-estimation of night-shift work by day-shift colleagues, reporting night work as a source of tension with friends, or feeling more irritable since working at night also impaired QWL. By contrast, satisfaction regarding COVID information received from the employer, and feeling valued by the general population during the pandemic improved QWL.

Conclusions
Insufficient access to screening, information, and protective measures impaired QWL of NSHW after the first wave of COVID-19 in Paris public hospitals. Social and professional recognition of night-shift work were the key determinants of QWL in this population.
Potential complications of CAD/CAM-produced resin composite crowns on molars: A retrospective cohort study over four years
Authors: Inomata Miyu , Harada Akio , Kasahara Shin , Kusama Taro , Ozaki Akane , Katsuda Yusuke , Egusa Hiroshi 
Published: April 2022

Purpose
Evaluation of the clinical performance of computer-aided design/computer-aided manufacturing-produced resin composite crowns (CAD/CAM composite crowns) on molars with a particular focus on placement location.

Methods
A retrospective cohort study was performed based on the clinical records of patients with CAD/CAM composite crowns on molars (June 2016 to March 2021). The hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated based the Cox proportional hazard model to evaluate the effect of tooth location on complication type and occurrence. Covariates included crown location (maxilla/mandible, distalmost tooth/not distalmost tooth, and first molar/second or third molar) and endodontically treated (nonvital) or untreated (vital) tooth.

Results
Overall, 362 crowns were evaluated (mean follow-up: 378 days, median: 286 days), and 106 crowns (29.3%) showed complications, most frequently crown debonding. The cumulative success and survival rates were 70.9% and 93.7%, respectively, after 1 year and 49.5% and 86.5%, respectively, after 3 years. There was no significant difference in the HRs and log-rank tests in the Kaplan–Meier curves based on crown location parameters (P > 0.05). However, placement on vital teeth was associated with higher risks than on nonvital teeth (HR, 1.55; 95% CI, 1.03–2.23). In addition, the cement as a covariate yielded a high HR.

Conclusions
The location of CAD/CAM composite molar crowns is unlikely a risk factor for complications; therefore, these crowns can be clinically applied to all molars. However, the application of such molar crowns to vital teeth and the use of a cement other than adhesive resin cement present risks.
A multi-stage process to develop quality indicators for community-based palliative care using interRAI data
Authors: Guthrie Dawn M. , Williams Nicole , Beach Cheryl , Buzath Emma , Cohen Joachim , Declercq Anja , Fisher Kathryn , Fries Brant E. , Goodridge Donna , Hermans Kirsten , Hirdes John P. , Seow Hsien , Silveira Maria , Sinnarajah Aynharan , Stevens Susan , Tanuseputro Peter , Taylor Deanne , Vadeboncoeur Christina , Martin Tracy Lyn Wityk 
Published: April 2022

Background
Individuals receiving palliative care (PC) are generally thought to prefer to receive care and die in their homes, yet little research has assessed the quality of home- and community-based PC. This project developed a set of valid and reliable quality indicators (QIs) that can be generated using data that are already gathered with interRAI assessments—an internationally validated set of tools commonly used in North America for home care clients. The QIs can serve as decision-support measures to assist providers and decision makers in delivering optimal care to individuals and their families.

Methods
The development efforts took part in multiple stages, between 2017–2021, including a workshop with clinicians and decision-makers working in PC, qualitative interviews with individuals receiving PC, families and decision makers and a modified Delphi panel, based on the RAND/ULCA appropriateness method.

Results
Based on the workshop results, and qualitative interviews, a set of 27 candidate QIs were defined. They capture issues such as caregiver burden, pain, breathlessness, falls, constipation, nausea/vomiting and loneliness. These QIs were further evaluated by clinicians/decision makers working in PC, through the modified Delphi panel, and five were removed from further consideration, resulting in 22 QIs.

Conclusions
Through in-depth and multiple-stakeholder consultations we developed a set of QIs generated with data already collected with interRAI assessments. These indicators provide a feasible basis for quality benchmarking and improvement systems for care providers aiming to optimize PC to individuals and their families.
Growth properties of meromorphic solutions of some higher-order linear differential-difference equations
Authors: Bellaama Rachid , Belaïdi Benharrat 
Published: April 2022

Abstract
This paper is devoted to the study of the growth of
meromorphic solutions of homogeneous and non-homogeneous linear
differential-difference equations

∑

i
=
0

n

∑

j
=
0

m

A

i
⁢
j

⁢

f

(
j
)

⁢

(

z
+

c
i

)

=
0

,

\displaystyle\sum_{i=0}^{n}\sum_{j=0}^{m}A_{ij}f^{(j)}(z+c_{i})=0,

∑

i
=
0

n

∑

j
=
0

m

A

i
⁢
j

⁢

f

(
j
)

⁢

(

z
+

c
i

)

=
F

,

\displaystyle\sum_{i=0}^{n}\sum_{j=0}^{m}A_{ij}f^{(j)}(z+c_{i})=F,

where

A

i
⁢
j

{A_{ij}}

(

i
=

0
,
…
,
n

{i=0,\ldots,n}

,

j
=

0
,
…
,
m

{j=0,\ldots,m}

), F are meromorphic
functions and

c
i

{c_{i}}

(

0
,
…
,
n

{0,\ldots,n}

) are non-zero distinct complex
numbers. Under some conditions on the coefficients, we extend early results
due to Zhou and Zheng.
Competitive adsorption of heavy metals in a quaternary solution by sugarcane bagasse – LDPE hybrid biochar: equilibrium isotherm and kinetics modelling
Authors: Ighalo Joshua O. , Ogunniyi Samuel , Adeniyi Adewale George , Igwegbe Chinenye Adaobi , Sanusi Saheed Kayode , Adeyanju Comfort A. 
Published: April 2022

Abstract
Sugarcane is a notable crop grown in the tropical region of the world. It is an abundant waste material of the sugar industry which is a low cost and low combustion fuel thus the bagasse can be exploited to manufacture adsorbents for water treatment. Because the presence of contaminants in polluted water is not uniform, pollutant species compete for active sites during the adsorption process. Investigation of the competitive adsorption of Zn(II), Cu(II), Pb(II), and Fe(II) in a quaternary solution using hybrid biochar developed from sugarcane bagasse (SCB) mixed Low-Density Polyethylene (LDPE) and pure SCB biochar is the main aim of this study. The biochar was developed using the retort carbonisation process and characterised via SEM (Scanning Electron Microscopy), BET (Branueur Emmett Teller) analysis, and FTIR (Fourier Transform Infrared Spectroscopy). Both biochar species mixture possessed some orbicular properties with mesoporous heterogeneous superficial morphology. The biomass biochar and hybrid biochar specific surface area are 533.6 m2/g and 510.5 m2/g respectively. For the two used adsorbents, >99% removal efficiency was recorded over the sphere for dosage investigation. Thus, this implies they are capable of removing heavy metals from the aqueous solution simulated. The Langmuir isotherm fitted best in each domain however there was an exception for Pb(II) ions in biomass biochar with the experimental adsorption capacity of ∼ 22 mg/g for the HMs. Based on the correlation coefficient (R
2); the experimental data fitted the pseudo-first-order kinetic model well having a correlation coefficient value of greater than 0.9. The mechanism of adsorption for the HMs was chemisorption. This study has a three-pronged benefit of water treatment, resource conservation, and solid waste utilisation.
A hypothesis that Notopterol may be effective in COVID-19 via JAK/STAT and other signaling pathways
Authors: Nazari-Khanamiri Fereshteh , Ghasemnejad-Berenji Morteza 
Published: April 2022

Abstract
COVID-19 is a rapidly spreading disease, causing a global pandemic. It is circulating in multiple countries and causing a series of respiratory infections. Due to the uncertain safety and efficacy of the vaccines and lack of specific medicines, it’s important to investigate new pharmacological procedures and find out new drugs that help us eradicate this pandemic. We suggest the hypothesis that Notopterol (NOT), the main Secondary metabolite of Notopterygium incisum Ting ex H.T (a common Chinese medicinal herb), may have the potential benefits on SARS-CoV2 infection for this reasons: (a) NOT exhibits anti-inflammatory, anticancer, and anti-angiogenic properties, (b) NOT indicates a significant reduction in cytokines and chemokines releasing including TNFa, IL-6, interferon-γ, which may decrease COVID-19 cytokine storm (c) NOT can suppress the expression of genes which leads to inflammation via Janus kinase/signal transducers and activators of transcription (JAK-STAT) signaling pathway. It is exactly acting like tocilizumab, (an approved drug against COVID-19) and (d) Notopterygium incisum has antiviral activity against influenza virus, it can reduce the viral-induced oxidative stress. By these explanations, it is hopeful that NOT may be effective in COVID-19 infections which needs further investigations to examine Notopterol as a beneficial agent against the SARS-CoV2 infection.
Inquiry into online learning communities: potential for fostering collaborative writing
Authors: Wu Wenli , Ma Qing , Santos Ieda M. 
Published: April 2022

Abstract
This study used a community of inquiry (CoI) framework to investigate the potential in terms of fostering collaborative writing of integrating online learning communities (OLCs) with English language learning. The aim was to examine the possible impacts of out-of-class OLCs (guided by teachers) on students’ collaborative English writing outcomes and learning satisfaction. In accordance with the CoI framework, an experiment was conducted and both quantitative (end-of-semester group essay scores) and qualitative (interviews and field notes) data were collected. The results indicate the teacher-guided out-of-class OLC approach to be more effective than the lecture-based approach when it comes to fostering English learners’ collaborative writing. More specifically, the online approach helps students to write better group research essays, develop higher levels of satisfaction concerning their learning experiences and devote more time to the learning process. The results suggest that future studies of OLCs should examine the provision of safe and supportive learning environments intended to foster autonomous learning. Moreover, the results have a number of implications with regard to enhancing students’ learning motivation in out-of-class OLCs.
Rationalizing the Cretan Hieroglyphic signlist
Authors: Montecchi Barbara , Ferrara Silvia , Valério Miguel 
Published: April 2022

Abstract
Ever since the publication of the first and unsurpassed corpus of Cretan Hieroglyphic inscriptions by Louis Godart and Jean-Pierre Olivier, Corpus Hieroglyphicarum Inscriptionum Cretae, known as CHIC, there has been no systematic or comprehensive reassessment of several difficult readings of signs and sign groups geared towards a rationalization of the sign-list. In this article, we discuss several readings in depth, by engaging with issues that relate to script classification, sign frequencies, interpretative uncertainties, and new finds post CHIC. Specifically, we highlight inconsistencies in the graphic behavior of signs, especially those of singular attestations (‘hapax’) or low frequency, and we also reassign uncertain cases that may be more likely read as Linear A rather than Cretan Hieroglyphic. As a steppingstone in rationalizing the sign-list, we apply a systematic approach to the material by means of a thorough sign-by-sign paleographic and structural reassessment, also presenting the resulting inventory.
Milyan dialectal divergence and its traces in onomastics
Authors: Martínez Rodríguez Elena 
Published: April 2022

Abstract
Taking as a starting point the discussion of the emendation of xina ‘grandmother’ in Schurr’s latest edition of the Milyan version of the Xanthos Pillar (Schurr 2018), this article deals with two different equations Mil. <i> : Lyc. <a/a͂/n> and Lyc. <a/a͂/n> : Lyc. <u>, argued to share the same phonetic trigger ie. the presence of an alveolar nasal, and explores the phonetic correlation through establishing new cognates between the two languages, or by adding new evidence to old open questions such as the phonetic value of <u> or the likely interchangeability of <a>, <a͂> and <n>. The Greek adaptation of the onomastic material will allow the phonetic nature of the nasal <n> in the cluster /xnt-/ (Lyc. xñtawati- ‘ruler’, cf. Luw. handawat(i)-): Gr. Κενδ-, Κινδ-, Κονδ- to be addressed, and ultimately compare the phonetic developments of Lycian and Milyan with its possible traces in the Greek sources of classical Lycia.
A pithos with Lycian inscription from Patara
Authors: Dündar Erkan , Réveilhac Florian 
Published: April 2022

Abstract
The excavations at the Tepecik settlement, which is situated East of Patara’s city center directly overlooking the ancient harbor, furnishes new and important data regarding the city’s largely unknown and much debated administrative organization in the 6th century BC. This evidence is based preliminarily on a pithos fragment found in the tower house’s eastern side, dated to ca. 500 BC, and bearing an inscription made ante cocturam in Lycian script. This graffito, which is one of the oldest inscriptions of the Lycian corpus, is incomplete but has eight legible letters that allow its reconstruction: it probably corresponds to the official title [pd]ḍẽnehm̃mi “ruler, commissioner”, attested in two other Lycian inscriptions. The graffito could indicate that the pithos was to be stored in the house of this official.