bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real‐world experience with weight gain among pregnant women living with HIV who are using integrase inhibitors
Authors: Fuller Trevon , Fragoso da Silveira Gouvêa Maria Isabel , Benamor Teixeira Maria de Lourdes , Ferreira Medeiros Adriana , Amorim da Silva Patricia , Medeiros Braga Camile , Constan Werneck Sant'anna Miriam , de Mattos Salgueiro Mariza , da Silveira Bressan Clarisse , Mendes‐Silva Wallace , João Esau C. 
Published: September 2022

AbstractObjectivesWe assessed real‐world weight change and pregnancy outcomes among pregnant women living with HIV who used integrase strand transferase inhibitor (INSTI)‐based combined antiretroviral therapy (cART).MethodsIn a retrospective cohort study from 2014 to 2021 for prevention of perinatal HIV infection, we evaluated changes in weight from the first prenatal visit to near delivery for two groups. The categories of change were: low (< 0.18 kg/week), normal (0.18–0.59 kg/week), and high (> 0.59 kg/week). The backbones were lamivudine + tenofovir disoproxil or lamivudine + zidovudine. The comparison groups were women with body mass index (BMI) < 25 kg/m2 versus BMI ≥ 25 kg/m2 and INSTI‐naïve versus INSTI‐experienced. Continuous variables were analysed with a Kruskal–Wallis test and count or categorical data with χ2 tests.ResultsWe enrolled 198 pregnant women. At study entry, 74 had BMI < 25 kg/m2 and 124 had BMI ≥ 25 kg/m2. Excess gestational weight gain was more frequent among women who were INSTI‐naïve among both BMI groups (< 25 and ≥ 25). However, the proportion of participants per weight change category was only significantly different between INSTI‐naïve women with baseline BMI < 25 kg/m2 and INSTI‐experienced women with BMI < 25 kg/m2. In particular, INSTI‐naïve women with BMI < 25 kg/m2 had significantly higher rates of excess gestational weight gain (31.6%) compared with participants with BMI < 25 kg/m2 who conceived while on INSTIs (11.8%, p = 0.004). Rates of unfavourable pregnancy outcomes were low and did not differ significantly between groups.ConclusionsINSTI‐naïve participants with BMI < 25 kg/m2 gained more weight during pregnancy than participants with BMI ≥ 25 kg/m2 who conceived while using INSTIs. Rates of adverse pregnancy outcomes did not differ between the groups.
Outcomes reporting in systematic reviews on revitalization: A scoping review for the development of a core outcome set
Authors: Cushley Siobhan , McLister Conor , Lappin Mark J. , Harrington Marc , Nagendrababu Venkateshbabu , Duncan Henry F. , El karim Ikhlas 
Published: September 2022

AbstractBackgroundRevitalization is a type of regenerative endodontic treatment (RET) that offers the exciting prospect of revitalizing damaged tissue, therefore improving outcomes for non‐vital immature teeth. To evaluate its potential, there needs to be consistency in outcome reporting of clinical studies investigating revitalization to allow for evidence synthesis and inform clinical decision making.ObjectivesThe aim of this scoping review was to identify outcomes that are reported in systematic reviews on revitalization including how and when these outcomes are measured. Additionally, evidence of selective reporting bias in the reviews was assessed.MethodsA comprehensive electronic search of healthcare databases and grey literature was conducted to identify systematic reviews published in the English language reporting outcomes of revitalization in permanent immature teeth. There was no restriction on the date of publication. Outcome data was extracted by four reviewers independently and mapped with a healthcare taxonomy into five core areas: survival, clinical/physiological changes, life impact, resource use and adverse events. Selective reporting bias and how it was measured was assessed independently by two reviewers.ResultsTwenty‐six systematic reviews were included in this scoping review. There was lack of standardization in reporting and significant heterogeneity across reviews in outcome endpoints. The outcomes reported could be aligned within the five core areas of the taxonomy including tooth survival which was reported in nine reviews. Patient‐reported outcomes were generally limited and no review reported on Oral Health Related Quality of Life. Many of the reviews reporting on randomized control trials were at low risk of selective reporting bias whilst other study designs were at higher risk.DiscussionConsistency in outcome reporting is necessary to realize the benefits of old but particularly novel therapies. Data from this review confirmed heterogeneity in reporting outcomes of revitalization and the need for development of a core outcome set (COS).ConclusionsSeveral important outcomes including survival, root development, tooth discolouration and periapical healing have been identified in this review which could inform the development of a COS in this area.RegistrationCore Outcome Measures in Effectiveness Trials (COMET) database (registration no. 1879).
Alumina‐spinel castable for steel ladles: An overview
Authors: Kumar Satyam , Sarkar Ritwik 
Published: September 2022

AbstractAlumina‐spinel castable has excellent refractory properties, including high volume and thermal stability, good hot strength, and excellent resistance against corrosion, erosion, and thermal spalling. Excellent refractory properties have made it a preferred lining for steel ladles, reducing the erosion and corrosion of molten metal and slag and improving the ladle life and efficiency for decades. These castables are also significant for the replacement of chrome‐bearing refractories that cause several health hazards. The current review paper covers preformed and in situ spinel containing alumina castables. It focuses on the importance of these castables in the sidewall and bottom portion of the steel ladle in detail, the effect of spinel and MgO content, and the factors affecting castable properties. The review also covers the final properties of castable and the application areas of alumina‐spinel castable in steel ladle, purging plugs, and RH‐degasser.
Predictors of rapid progression of estimated glomerular filtration rate among persons living with diabetes and/or hypertension in Ghana: Findings from a multicentre study
Authors: Ofori Emmanuel , Gyan Kwadwo Faka , Gyabaah Solomon , Nguah Samuel Blay , Sarfo Fred Stephen 
Published: September 2022

AbstractIn Ghana, the prevalence of chronic kidney disease (CKD) is 28.5% in diabetic hypertensive patients, 26.3% in hypertensives, and 16.1% in those with diabetes only. Trajectories of estimated glomerular filtration rate (eGFR) among patients with hypertension and diabetes are important for monitoring and instituting prompt interventions to prevent the development of CKD, especially in the face of limited access to renal replacement therapy. In this prospective multi‐center study conducted at five hospitals in Ghana, we assessed predictors of rapid eGFR progression among adults with hypertension and/or diabetes. Serum creatinine at baseline and 18 months were taken and eGFR determined using the CKD‐EPI formula. eGFR trajectory was defined as fast when the decline of GFR was ≥ 5 ml/min/1.73 m2 per year. A multivariable logistic regression model was fitted to identify predictors of the fast progression of eGFR. Total 13% of 1261 participants met the criteria for rapid decline in eGFR. The adjusted odds ratio, aOR (95%CI), of four factors adversely associated with fast progression of eGFR were: increasing age 1.20 (1.03–1.14), partial health insurance coverage for medications 1.48 (1.05–2.08), history of smoking 1.91 (1.11–3.27), angiotensin‐receptor blockade use 1.55 (1.06–2.25) while metformin use was protective .56 (.35–.90). Proportion with eGFR <60 ml/min increased from 14% at baseline to 19% at month 18. Effective health insurance policies to improve medication access and avoidance of smoking are interventions that may mitigate the rising burden of CKD in individuals with diabetes mellitus and/or hypertension.
A retrospective analysis of EBV‐DNA status with the prognosis of lymphoma
Authors: Qiu Lihua , Si Junqi , Kang Junnan , Chen Zehui , Nuermaimaiti Rexidan , Qian Zhengzi , Li Lanfang , Zhou Shiyong , You Mingjian James , Zhang Huilai , Tian Chen 
Published: September 2022

AbstractEpstein–Barr virus (EBV) infection is proved to be associated with clinicopathology of lymphoma. However, little is known about the relationship between EBV‐DNA status after treatment and prognosis. In this study, real‐time polymerase chain reaction (PCR) was used for quantitative detection of EBV‐DNA load in peripheral blood of all 26,527 patients with lymphoma, and the clinical characteristics and prognosis of 202 patients were retrospectively analysed, including 100 patients with positive EBV‐DNA and 102 randomly selected patients with negative EBV‐DNA. We found that the average rate of EBV‐DNA positivity in lymphomas was 0.376%, and EBV‐DNA‐positive patients presented higher risk with elevated lactate dehydrogenase (LDH) and β2‐MG level, B symptoms, secondary hemophagocytic syndrome and lower objective response rate compared to EBV‐DNA‐negative patients. Multivariate analysis revealed EBV‐DNA‐positive patients had inferior progression‐free survival (PFS) and overall survival (OS) and EBV‐DNA level before treatment was related to PFS but not OS of T/NK cell lymphoma. In T/NK cell lymphoma, EBV‐DNA converting negative after treatment was correlated with better PFS but not OS, and second‐line therapy could induce more EBV‐DNA‐negative conversion compared to CHOP‐based therapy. In all, EBV‐DNA positivity before treatment can be a biomarker representing the tumour burden and an independent prognostic factor. EBV‐DNA‐negative conversion after treatment is a good prognostic factor for T/NK cell lymphomas.
Hepatitis C viral load and mother‐to‐child transmission: A systematic review and meta‐analysis
Authors: Deng Songqing , Zhong Wenfang , Chen Wen , Wang Zilian 
Published: September 2022

AbstractBackground and AimWe aim to assess the association between maternal hepatitis C virus (HCV) viral load and human immunodeficiency virus (HIV) coinfection and the risk for mother‐to‐child transmission (MTCT) among pregnant women infected with HCV.MethodsA literature search of the Medline, Embase, Central, Science Citation Index Expanded (SCIE), Conference Proceedings Citation Index‐Science (CPCIS), Scopus, Literature Latino‐Americana e do Caribe em Ciências da Saúde (LILACS), and WHO Global Index Medicus databases, from inception to June 21, 2022, was performed. Studies that reported the incidence HCV‐MTCT were included. Pooled effect estimates were calculated using the random‐effects model, and Holm–Bonferroni correction was performed for multiple pooled associations.ResultsThe present meta‐analysis included 26 studies involving 4934 newborns with maternal HCV infection. Pregnant women with HCV viremia exhibited increased risk for MTCT (odds ratio [OR] 8.25 [95% confidence interval (CI) 4.65–14.63]) compared with those negative for HCV‐RNA. Multiple subgroup analysis revealed that the HCV viremia/HIV‐positive group demonstrated the highest risk for HCV MTCT, followed by the HCV viremia mono‐infected group, while HCV‐RNA‐negative women demonstrated the lowest risk for HCV MTCT. Among females with HCV viremia, elevated risk for MTCT was found among subjects with a viral load ≥ 6 log10 copies/mL compared with those with viral load < 6 log10 copies/mL (OR 4.58 [95% CI: 2.52–8.34]).ConclusionThe incidence of HCV MTCT was increased among pregnant women with detectable HCV viremia and was even higher in those with a viral load ≥ 6 log10 copies/mL. HIV coinfection further increased the risk for HCV MTCT.
Autobiographical memory impairment in chronic schizophrenia: Significance and clinical correlates
Authors: Herold Christina J. , Lässer Marc M. , Schröder Johannes 
Published: September 2022

AbstractPrevious studies of autobiographical memory (AM) in schizophrenia yielded a reduction of specificity, richness of details and conscious recollection, which indicate both, quantitative and qualitative AM changes. However, their associations with psychopathological symptoms and neuropsychological deficits were not resolved. Therefore, we sought to investigate AM with respect to psychopathology and neuropsychology in patients with chronic schizophrenia to rule out the influence of different courses of the disease. AM of four lifetime periods was examined in 75 patients and 50 healthy controls by using a semi‐structured interview. The recalled episodes were rated for memory specificity. Subsequently, one single event of each period of life was rated for details and experiential aspects of reliving (originality, vividness/visual imagery, emotional re‐experiencing and emotional valence). When contrasted with healthy controls, patients recalled a significantly reduced number of episodes and personal semantic facts; moreover, memory specificity of AM was significantly lower in patients than controls. While the richness of details calculated for single events showed only minor, non‐significant group differences, vividness and emotional re‐experiencing were significantly less pronounced in the patient group. Along with this, AM performance correlated significantly with negative symptoms including apathy as well as verbal memory and executive functions. Our results underline the significance of overgenerality as a key feature of AM in schizophrenia as well as a dissociation between intact number of details of single events and reduced vividness and emotional re‐experiencing. The extent of negative symptoms including apathy and impairments of verbal memory/executive functions may explain AM deficits in chronic schizophrenia.
Evaluation of supratrochlear artery depth and course variations by Doppler ultrasonography along the glabellar frown lines for safer filler injections
Authors: Güvenç Ulaş , Ten Barış , Kaya Tamer İrfan , Yüksek Hasan Hüsnü , Türsen Ümit 
Published: September 2022

AbstractPurposeHyaluronic acid (HA) injection is a popular nonsurgical, rejuvenating procedure to treat glabellar frown lines, which has devastating complications such as blindness and skin necrosis due to the arterial occlusion of supratrochlear artery (STA). Therefore, when injecting into the frown lines, knowledge of the STA's depth and plane is necessary to prevent possible adverse events. The aim of this study was to identify the depths of STA in the area of the frown lines in order to maximize safety during filler injections.MethodsSupratrochlear artery depth measurements were performed at the level of eyebrow and at the level of 1.5 cm above the eyebrow. Superficial duplex Doppler ultrasonography was performed of 71 cases.ResultsIn the eyebrow level, the epidermis‐artery distance (EAD) is between 1,8 and 5.9 mm, and the artery‐periost distance (APD) is between 0.7 and 3.7 mm. In the 1.5 cm superior level of the eyebrow, the EAD is between 1.8 and 5.1 mm and the APD is between 0.6 and 3.8 mm. There was no significant difference between the depth measurements of the right and left STA. At the eyebrow level, APD is greater in men than in women. As the body mass index increases, the EAD and APD depth increases. EAD depth increases with increasing age.ConclusionsBased on the findings of this study, safe filler injections to correct the glabellar frown lines can be possible with intradermal injections just below the ryhtide. In the glabellar region, subcutaneous and supraperiosteal injections seems to be risky.
Study on the correlation of high expression level of HuD with seborrheic keratosis and skin aging
Authors: Chen Juping , Liu Jun , Wang Zheng , Xu Jiandan , Tao Jia , Li Hualing 
Published: September 2022

AbstractBackgroundCurrently, most studies of ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)‐like protein 4 (Hu antigen D, HuD) focus on nervous system‐related diseases; the role of HuD in the occurrence of skin aging and seborrheic keratosis (SK) has not been reported.ObjectiveTo explore the role of HuD in the occurrence of SK and skin aging and its related clinical significance.MethodsThe expression levels of HuD in the skin and blood of healthy people at different ages, SK lesions, and perilesional skin of SK patients were detected by both immunohistochemistry and Western blotting. The mRNA expression levels of HuD in the skin and blood of healthy peoples at different ages were detected by quantitative real‐time reverse transcription‐polymerase chain reaction. The expression level of HuD was compared with the skin of healthy people, SK lesion, and perilesional skin of SK patients of the same age.ResultsThe immunohistochemistry and Western blotting showed that the expression levels of HuD in SK lesions were higher than those in healthy skin and perilesional skin. The immunohistochemical staining intensity, protein and mRNA expression levels of HuD in the skin and blood of healthy people were correlated with age, which gradually increased with increasing age.ConclusionHuD is highly expressed in SK lesion and aged skin, indicating that a higher HuD expression level is correlated with occurrence of SK and aging skin; however, its mechanism needs to be further studied.
The effect of delayed umbilical cord clamping on Newborn's oxygen saturation and sucking success in primiparous pregnant
Authors: Taşkin Rumeysa , Kanbur Ayla 
Published: September 2022

AbstractAimThe objective of this study was to examine the effect of delayed umbilical cord clamping on the newborn's oxygen saturation and sucking success in primiparas.MethodsThe study was conducted based on the experimental model with a control group, between March 15–November 10, 2020. The sample of the study consisted of 101 primiparous pregnant (48 primiparous with delayed cord clamping within 1–3 min and 53 primiparous with early cord clamping within 1 min) (having no high‐risk pregnancy, 38–42 weeks, vaginal birth) in Turkey. The data were collected using a personal information form, the LATCH breastfeeding tool and the pulse oximetry. Statistical analyses were conducted using percentage distribution, arithmetic means, chi‐square testing, and independent samples t‐testing.ResultsOxygen saturation values of newborns with delayed umbilical cord clamping were higher than those of newborns with early cord clamping. The saturation was first minute 66.43 versus 74.37, fifth minute 81.90 versus 88.60, tenth minute 91.77 versus 94.50 (p < 0.05). When compared to the group with early cord clamping, oxygen saturation is higher in the first by 11.95%, in the fifth by 8.18%, and in the tenth minute by 2.97% in the group with delayed cord clamping. The LATCH breastfeeding scores were found to be higher in the group with delayed cord clamping compared to the group with early cord clamping.ConclusionIt was determined that delayed cord clamping positively affected oxygen saturation values and sucking success in neonatal babies. Delayed umbilical cord clamping is an important issue that needs to be addressed in its different dimensions.
José Ortega y Gasset (1934), Ibn Khaldūn Reveals the Secret to Us (thoughts on Africa Minor) translated from Spanish by Cynthia Scheopner
Authors: Scheopner Cynthia 
Published: September 2022

AbstractJosé Ortega y Gasset (1883–1955) was puzzled how Melilla remained a Spanish enclave on the North African coast. By 1927, Spain had solidified its hold on Northern Morocco and several books on the history and culture of “Africa minor” had been published; in one Ortega encountered Ibn Khaldūn. Ortega read the Prolegomena to History in the French translation by William MacGuckin de Slane. He found a key to understanding Spain that he explored in this essay, first published in El Espectador journal of Madrid in 1934. It introduced Ibn Khaldun to European audiences as the first philosopher of history three decades before an English translation of his work. Ortega, then, knew of Ibn Khaldun's theory of generations at the time he was developing his own. Ortega noted page numbers in parentheses in the text where he quoted from De Slane. The end notes are from the text as well, documenting Ortega's secondary sources for his impressions of Ibn Khaldūn, Islam, and North African culture.
Nursing staff and nursing managers' experiences of using the interRAI ID instrument in assessing the service needs of persons with intellectual disabilities in housing services
Authors: Kangasniemi Hanna , Ryhtä Iina , Stolt Minna 
Published: September 2022

AbstractThe assessment of service needs among persons with intellectual disabilities (ID) is important to identify a person's needs, strengths and preferences. One commonly used instrument for service needs assessment is Resident Assessment Instrument Intellectual Disabilities (interRAI ID). However, there is limited evidence of the experiences of using interRAI ID for assessing the service needs of persons with ID from nursing staff and nursing managers' perspective. The aim of this study was to explore the suitability of the interRAI ID instrument (version Fi2020.1) for assessing the service needs and functional development of persons with ID as described by nursing staff and nursing managers working in a housing service. The data were collected using focus group interviews (n = 3) in May 2020. The interviews were conducted in units providing housing services for persons with ID (n = 6). The interview groups consisted of nursing staff (n = 22) and nursing managers (n = 6). The data were analysed using inductive content analysis. The experiences of nursing staff and nursing managers fell under three main categories: (1) the assessment process; (2) possibilities to use the assessment data and (3) implementation experience. The interRAI ID instrument is suitable and useful for the systematic assessment of the health, functional capacity and service needs of persons with ID. In the future, effective and evidence‐based methods are needed to promote the assessment skills of nursing staff and to use assessment data in nursing practice as well as nursing management.
Pharmacokinetics and therapeutic efficacies of fenbendazole in comparison with levamisole in helminth‐infected Caspian turtles (Mauremys caspica)
Authors: Youssefi Mohammad Reza , Khabbazian Faezeh Ghiami , Navidi Niki , Yazdani Rostam Mohammad Mehdi , Giorgi Mario , Abouhosseini Tabari Mohaddeseh 
Published: September 2022

AbstractThe pharmacokinetics and bioavailability of fenbendazole and levamisole were determined in Caspian turtles after a single intravenous (i.v.) and subcutaneous (s.c.) administration. Thirty turtles diagnosed as naturally infected with Serpinema microcephalus and Falcaustra armenica nematodes received fenbendazole (50 mg/kg) or levamisole (10 mg/kg) by i.v. and s.c. administrations. Blood samples were collected at time 0, 0.125, 0.25, 0.5, 1, 2, 4, 8, 12, 24, and 48 h after drug administration. Plasma drug concentrations were determined by a validated high‐performance liquid chromatography method. Data were analyzed by noncompartmental methods. The mean elimination half‐life of levamisole was 5.16 h and 12.03 h for i.v. and s.c. routes, respectively, and for fenbendazole, the mean elimination half‐life was 25.38 h (i.v.) and 29.77 h (s.c.). The total clearance and volume of distribution at steady‐state for levamisole and fenbendazole following i.v. administration were 0.22, 0.44 ml/g/h, and 1.06 and 7.35 ml/g, respectively. For the s.c. route, the peak plasma concentration of levamisole and fenbendazole was 10.53 and 5.24 μg/mL, respectively. The s.c. bioavailability of levamisole and fenbendazole was complete. Considering high anthelmintic efficacy and bioavailability after s.c. administration of levamisole and fenbendazole, and the absence of adverse effects, this route of administration is an easy and efficacious way of treating nematodes in Caspian turtles.