bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Arrhenius barrier crossing dynamics of non-equilibrium non-Markovian systems
Authors: Lavacchi Laura , Daldrop J. O. , Netz Roland R. 
Published: August 2022

Abstract
The non-equilibrium non-Markovian barrier crossing dynamics of a one-dimensional massive coordinate, described by the non-equilibrium version of the generalized Langevin equation with unequal random and friction relaxation times, is studied by simulations and analytical methods. Within a harmonic approximation, a general formula for the barrier crossing time is derived which agrees favorably with simulations. Non-equilibrium random forces with a relaxation time longer than the friction relaxation time induce non-Arrhenius behavior and dramatically increase the barrier crossing time; within the harmonic theory this corresponds to a reduced effective temperature which also modifies the spatial and velocity distributions.
Roles of phosphatidylserine and phospholipase C in the activation of TOR complex 2 signaling in Saccharomyces cerevisiae
Authors: Nomura Wataru , Ng Su-Ping , Takahara Terunao , Maeda Tatsuya , Kawada Teruo , Goto Tsuyoshi , Inoue Yoshiharu 
Published: August 2022

ABSTRACT
Target of rapamycin (TOR) forms two distinct complexes, TORC1 and TORC2, to exert its essential functions in cellular growth and homeostasis. TORC1 signaling is regulated in response to nutrients such as amino acids and glucose; however, the mechanisms underlying the activation of TORC2 signaling are still poorly understood compared to those for TORC1 signaling. In the budding yeast Saccharomyces cerevisiae, TORC2 targets the protein kinases Ypk1 and Ypk2 (hereafter Ypk1/2), and Pkc1 for phosphorylation. Plasma membrane stress is known to activate TORC2–Ypk1/2 signaling. We have previously reported that methylglyoxal (MG), a metabolite derived from glycolysis, activates TORC2–Pkc1 signaling. In this study, we found that MG activates the TORC2–Ypk1/2 and TORC2–Pkc1 signaling, and that phosphatidylserine is involved in the activation of both signaling pathways. We also demonstrated that the Rho family GTPase Cdc42 contributes to the plasma membrane stress-induced activation of TORC2–Ypk1/2 signaling. Furthermore, we revealed that phosphatidylinositol-specific phospholipase C, Plc1, contributes to the activation of both TORC2–Ypk1/2 and TORC2–Pkc1 signaling.
Integrated Layout and Cable Routing in Wind Farm Optimal Design
Authors: Fischetti Martina , Fischetti Matteo 
Published: August 2022

We address a very important problem in offshore wind farm design, namely, the combined optimization of the turbine location and of the connection cables required to bring the electrical power produced by the turbines to a given substation, and eventually to shore. We first describe a mixed-integer linear programming model that combines previous proposals from the literature. Then we improve it by a number of additional inequalities intended to strengthen its linear programming relaxation. In particular, we propose new classes of Benders-like cuts derived from an induced-clique substructure of the problem. The validity of these cuts is established in a purely combinatorial way, without resorting to Benders’s standard duality theory, and efficient separation procedures are proposed. The practical effectiveness of the proposed cuts is established through computational tests, showing that they do improve very significantly the dual bound provided by the standard model. We also present an exact branch-and-cut solver for the problem, which separates the new cuts at run time. Computational results confirm that the new cuts are instrumental for the success of our exact solver. This paper was accepted by Chung-Piaw Teo, optimization. Funding: This work of Matteo Fischetti was supported by the Ministero dell’Istruzione, dell’Università e della Ricerca (MiUR), Italy [PRIN Project]. Supplemental Material: Data are available at https://doi.org/10.1287/mnsc.2022.4470 .
Incentive Effects of Subjective Allocations of Rewards and Penalties
Authors: Cai Wei , Gallani Susanna , Shin Jee-Eun 
Published: August 2022

We examine the incentive effects of subjectivity in allocating tournament-based rewards and punishments. We use data from a company where reward and punishment decisions are based on a combination of objective metrics and subjective performance assessments. Rankings based on the objective metrics and the ultimate payoff allocations are disclosed to all members of the organization. This information allows employees to observe whether and how managers subjectively override the objective rankings. Consistent with expectancy theory, we predict and find that subjective rewards and punishments manifesting as favorable (unfavorable) deviations from formula-based payoff expectations are associated with subsequent performance improvements (declines). These performance responses are incremental to the effects of receiving a reward or punishment per se. Our results suggest that managers can benefit from using subjective rewards, but using subjective punishments can be very costly in the absence of sufficiently strong ex ante incentive effects associated with the prospect of subjective penalties. Our findings contribute to the literature on subjectivity in performance evaluations and have important practical implications for designing incentive systems. This paper was accepted by Brian Bushee, accounting. Funding: The authors appreciate the Harvard Business School for financial support during the development of this study. Supplemental Material: Data are available at https://doi.org/10.1287/mnsc.2022.4501 .
The engagement of orthopaedic surgeons in diabetic foot care in England
Authors: Robinson A. H. N. , Garg Parag , Kirmani Sayyied , Allen Patricia 
Published: August 2022

Aims Diabetic foot care is a significant burden on the NHS in England. We have conducted a nationwide survey to determine the current participation of orthopaedic surgeons in diabetic foot care in England. Methods A questionnaire was sent to all 136 NHS trusts audited in the 2018 National Diabetic Foot Audit (NDFA). The questionnaire asked about the structure of diabetic foot care services. Results Overall, 123 trusts responded, of which 117 admitted patients with diabetic foot disease and 113 had an orthopaedic foot and ankle surgeon. A total of 90 trusts (77%) stated that the admission involved medicine, with 53 (45%) of these admissions being exclusively under medicine, and 37 (32%) as joint admissions. Of the joint admissions, 16 (14%) were combined with vascular and 12(10%) with orthopaedic surgery. Admission is solely under vascular surgery in 12 trusts (10%) and orthopaedic surgery in 7 (6%). Diabetic foot abscesses were drained by orthopaedic surgeons in 61 trusts (52%) and vascular surgeons in 47 (40%). Conclusion Orthopaedic surgeons make a significant contribution to both acute and elective diabetic foot care currently in the UK. This contribution is likely to increase with the movement of vascular surgery to a hub and spoke model, and measures should be put in place to increase the team based approach to the diabetic foot, for example with the introduction of a best practice tariff. Cite this article: Bone Jt Open 2022;3(8):618–622.
Detection of virulence factor encoding genes on Escherichia coli isolated from broiler chicken in Blitar District, Indonesia
Authors: EFFENDI MUSTOFA HELMI , FARIDAH HAYYUN DURROTUL , WIBISONO FRESHINDY MARISSA , WIBISONO FRESHINTA JELLIA , NISA NABILATUN , FATIMAH FATIMAH , UGBO EMMANUEL NNABUIKE 
Published: August 2022

Abstract. Efendi MH, Faridah HD, Wibisono FM, Wibisono FJ, Nisa N, Fatimah F, Ugbo EN. 2022. Detection of virulence factor encoding genes on Escherichia coli isolated from broiler chicken in Blitar District, Indonesia. Biodiversitas 23: 3437-3442. Broiler chicken is a source of protein that is widely consumed by the public. However, broiler chicken production sometimes decreases due to infectious diseases such as colibacillosis caused by pathogenic Escherichia coli possessing virulence genes. Virulence factors function to facilitate colonization and invasion of host cells to cause disease. The presence of these virulence factors is encoded by various genes such asthe increased serum survival gene and P fimbriae gene which plays a role in surface adhesion. The present study aims to detect the presence of virulence genes from extended-spectrum beta-lactamase (ESBL) producing E.coli isolated from broiler chickens in the Blitar District. A total of 110 cloacal swabs collected by systematic random sampling from broiler poultry farms in four different sub-districts were screened for ESBL-producing E. coli and virulence genes by phenotypic and molecular methods, respectively. Out of 110 E.coli recovered, 95 (86.4%) were observed to show a high level of resistance to the tested antibiotics, and 34 (35.7%) were ESBL-producers. Among ESBL producing E. coli isolates, 22 (73.5%) and 1 (2.9%) were found to have the iss and papC gene virulence factors, respectively using the polymerase chain reaction (PCR) method. The results of this study indicate that virulence genes can be found in E. coli from poultry farms. The iss gene is the most predominant virulence gene. The reportof these virulence factors in E. coli isolated from broiler could impose a serious potential public health problem.
Characterization, potential and conservation of Pisang Kates (Musa cv. ABB), a unique local banana cultivar from Pasuruan, East Java, Indonesia
Authors: HAPSARI LIA , DAMAIYANI JANIS , YULISTYARINI TITUT , AULIYA ITSAR , GUSMIATI LUTFIANA HASANAH , ZARO ROSHINDY MALFRIDATUL 
Published: August 2022

Abstract. Hapsari L, Damaiyani J, Yulistyarini T, Auliya I, Gusmiati LH, Zaro RM. 2022. Characterization, potential and conservation of Pisang Kates (Musa cv. ABB), a unique local banana cultivar from Pasuruan, East Java, Indonesia. Biodiversitas 23: 3521-3532. Characterization of local banana (Musa spp.) germplasm is fundamental for identification and provides information on traits that support their sustainable conservation and optimum utilization. This study aims to characterize and discuss the potential and conservation of Pisang Kates,a local cultivar originatingfrom Tutur, Pasuruan, East Java, Indonesia. The observed characteristics include morphology, molecular, agronomy and yield performance, leaf anatomy and stomata, pollen morphology and viability, fruit total soluble solids and nutrients. Results showed that Pisang Kates hasa unique fruit shape ovoid to globose, weight of40-150 g, appear solitary and randomly attached directly to peduncle, like papaya. It was molecularly by Internal Transcribed Spacer barcode confirmed as ABB genotype. It is tolerant to drought and banana bunchy top virus, but susceptible to wilts. Leaf anatomy has three palisades and isodiametric polygonal epidermals. Leaf stomata is amphistomatic, tetracytic on adaxial,and paracytic on abaxial. Pollen unit is monad, very large, subspheroidal, monocolpate aperture, granulum ornamentation, and low viability. Fruit moderately sweet with nutrient contents equal to dessert banana. Pisang Kates has potential as one serving consumer size fruit, ornamental fruit plant, female parent for breeding,and pioneer plant for rehabilitation programs. Both ex-situ and on-farm conservation strategies of this valuable local banana genetic resource are encouraged.
Phytochemical screening and antioxidant activity of methanol extract of Dillenia excelsa leaf
Authors: LISDIANI LISDIANI , SUSANTO DWI , MANURUNG HETTY 
Published: August 2022

Abstract. Lisdiani, Susanto D, Manurung H. 2022. Phytochemical screening and antioxidant activity of methanol extract of Dillenia excelsa leaf. Biodiversitas 23: 3827-3835. The aim of this study was to determine the phytochemical compounds, total flavonoid, and phenolic content, and antioxidant activity of the methanol extract of Dillenia excelsa (Jack) Martelli ex Gilg (or tanikkara) leaves. Sample D. excelsa leaves were obtained from swamp forests in Melintang Village, Muara Wis sub-district, Kutai Kartanegara district, East Kalimantan province, Indonesia. This research includes sample preparation, extraction and maceration, extract concentration using a rotary evaporator, phytochemical test, total phenolic andflavonoid content test, and antioxidant activity test using 2,2-diphenyl-1-picrylhydrazil (DPPH) and Ferric reducing antioxidant power methods (FRAP). The results of this study indicate that the methanolic extract of D. excelsa leaves contains secondary metabolites, including alkaloids, flavonoids, phenolics, triterpenoids, and tannins. The total phenolic content was 181.25 g GAE/g extract, while the total flavonoid content was 36 g QE/g extract. The antioxidant activity of the methanol extract of D. excelsa leaf DPPH method had moderate activity strength with a value of IC50is 145 ppm, while the antioxidant activity of the methanol extract of D. excelsa leaf using the FRAP method has the highest antioxidant activity value at a concentration of 100 ppm with a value of 70.833%. The result indicated that the methanolic extract D. excelsa leaves had many metabolites and potentially an antioxidant.
Aedes koreicus, a vector on the rise: Pan-European genetic patterns, mitochondrial and draft genome sequencing
Authors: Kurucz Kornélia , Zeghbib Safia , Arnoldi Daniele , Marini Giovanni , Manica Mattia , Michelutti Alice , Montarsi Fabrizio , Deblauwe Isra , Van Bortel Wim , Smitz Nathalie , Pfitzner Wolf Peter , Czajka Christina , Jöst Artur , Kalan Katja , Šušnjar Jana , Ivović Vladimir , Kuczmog Anett , Lanszki Zsófia , Tóth Gábor Endre , Somogyi Balázs A. , Herczeg Róbert , Urbán Péter , Bueno-Marí Rubén , Soltész Zoltán , Kemenesi Gábor 
Published: August 2022

Background
The mosquito Aedes koreicus (Edwards, 1917) is a recent invader on the European continent that was introduced to several new places since its first detection in 2008. Compared to other exotic Aedes mosquitoes with public health significance that invaded Europe during the last decades, this species’ biology, behavior, and dispersal patterns were poorly investigated to date.

Methodology/Principal findings
To understand the species’ population relationships and dispersal patterns within Europe, a fragment of the cytochrome oxidase I (COI or COX1) gene was sequenced from 130 mosquitoes, collected from five countries where the species has been introduced and/or established. Oxford Nanopore and Illumina sequencing techniques were combined to generate the first complete nuclear and mitochondrial genomic sequences of Ae. koreicus from the European region. The complete genome of Ae. koreicus is 879 Mb. COI haplotype analyses identified five major groups (altogether 31 different haplotypes) and revealed a large-scale dispersal pattern between European Ae. koreicus populations. Continuous admixture of populations from Belgium, Italy, and Hungary was highlighted, additionally, haplotype diversity and clustering indicate a separation of German sequences from other populations, pointing to an independent introduction of Ae. koreicus to Europe. Finally, a genetic expansion signal was identified, suggesting the species might be present in more locations than currently detected.

Conclusions/Significance
Our results highlight the importance of genetic research of invasive mosquitoes to understand general dispersal patterns, reveal main dispersal routes and form the baseline of future mitigation actions. The first complete genomic sequence also provides a significant leap in the general understanding of this species, opening the possibility for future genome-related studies, such as the detection of ‘Single Nucleotide Polymorphism’ markers. Considering its public health importance, it is crucial to further investigate the species’ population genetic dynamic, including a larger sampling and additional genomic markers.
Examination of a nutritional treatment pathway according to pretreatment health status and stress levels of patients undergoing hematopoietic stem cell transplantation
Authors: Aoyama Takashi , Imataki Osamu , Notsu Akifumi , Yurikusa Takashi , Ichimaru Koki , Tsuji Masanori , Yoshitsugu Kanako , Fukaya Masafumi , Enami Terukazu , Ikeda Takashi 
Published: August 2022

Introduction
This study aimed to validate hematopoietic stem cell transplantation (HSCT) treatment via a tailored nutritional pathway in myeloablative conditioning (MAC), determine its efficacy in terms of remission, and explore associations between clinical outcomes and nutritional indicators.

Methods
We included patients who underwent MAC for HSCT at the Shizuoka Cancer Center Stem Cell Transplantation between 2015 and 2019. We evaluated outcomes from the day before treatment initiation (transplant date: day 0) to day 42.

Results
Among the 40 MAC cases (participant characteristics: 20/40 males, mean age of 52 years, and mean body mass index of 21.9 kg/m2), we found that the percent loss of body weight and loss of skeletal muscle mass were correlated with the basal energy expenditure rate (BEE rate; r = 0.70, p<0.001 and r = 0.49, p<0.01, respectively). Based on the receiver operating characteristics curves, the cutoff value for the BEE rate in terms of weight loss was 1.1. Salivary amylase levels did not significantly change during the treatment course. Continuous variables, including oral caloric intake and performance status, showed statistically significant correlations with nutrition-related adverse events during treatment (r = −0.93, p<0.01 and r = 0.91, p<0.01, respectively). Skeletal muscle mass before treatment initiation was an independent predictive variable for reduced 2-year survival (p = 0.04).

Conclusion
Our results support the validity of a safe nutritional pathway with a BEE rate of 1.1 for HSCT patients pretreated with MAC. Specifically, we found that this pathway could prevent weight loss in response to nutrition-related adverse events. Skeletal muscle mass before treatment was identified as an independent risk factor for reduced 2-year survival.
Outcomes of asymptomatic recombinant tissue plasminogen activator associated intracranial hemorrhage
Authors: Teekaput Chutithep , Thiankhaw Kitti , Tanprawate Surat , Teekaput Kanokkarn , Chai-Adisaksopha Chatree 
Published: August 2022

Background
Intracranial hemorrhage (ICH) is the most devastating complication of recombinant tissue plasminogen activator (rtPA) treatment in acute ischemic stroke patients. Data on rtPA-associated asymptomatic ICH (aICH) are limited.

Objectives
To determine the incidence, risk factors, characteristics, management, and clinical outcome of rtPA-associated aICH.

Methods
The data were retrieved from the Chiang Mai University Hospital Stroke Registry between 1995 and 2019. Consecutive ischemic stroke patients were included if they were 18 or older and received rtPA. Study outcomes were the incidence and characteristics of aICH, management, 90-day modified Rankin scale (mRS), National Institute of Health Stroke Scale (NIHSS), Barthel index, and all-cause mortality.

Results
Of 725 rtPA treated patients, 166 (16.0%, 95% confidence interval [CI] 13.4–18.9) had aICH, 50 (6.9%, 95% CI 5.2–9.0) had symptomatic ICH (sICH). Patients with aICH had more hemorrhagic infarctions (HI) compared to sICH (81.9% vs 2.0%, P-value < 0.001). Fresh Frozen Plasma and cryoprecipitate were the most common blood products used to reverse the anticoagulant effect in sICH. Craniotomy was performed in 1% and 60% of patients who had aICH and sICH. At 90 days, patients who had aICH had poorer clinical outcomes (mRS, NIHSS and Barthel index) as compared to those without ICH. Compared to non-ICH patients, aICH patients were associated with increased risk of 90-day mortality, the hazard ratio (HR), 3.7, 95% CI 1.6–8.9.

Conclusions
The rtPA-associated aICH increased the risk of morbidity and mortality outcomes. Further treatment consensus, guideline generation, or clinical trials focusing on the treatment of rtPA-associated aICH may be required.
The Importance of Kant’s Schematism for Schelling’s Project of a Philosophy of Nature
Authors: Garcia Luis Fellipe 
Published: August 2022

Abstract
Counteracting a widespread interpretation of Schelling’s project of a philosophy of nature as anti-Kantian, this paper claims that Kant’s doctrine of the schematism plays a central role in the emergence and development of Schelling’s project. My argument will be structured in the following way. First, I will discuss Schelling’s reception of the schematism in his Ideas for a Philosophy of Nature of 1797, especially as regards his association of it with Kant’s dynamical conception of matter in the Metaphysical Foundations of Natural Science. Relying on this reconstruction, I will argue, secondly, that Schelling brings together a central issue of the Critique of Pure Reason (the objectivity of pure concepts) and the overall problem of the Metaphysical Foundations (the transition from pure philosophy to empirical sciences) by addressing the issue of a schematism specifically related to outer sense. Thirdly, I maintain that this issue is at the core of the overall argument developed in the Ideas, where it appears in the form of a schematism of “materiality as such”. Finally, I suggest that the notion of a schematism of materiality as such offers a useful key to understanding the unfolding of Schelling’s project between 1797 and 1800.
Characterization of egg shell powder-doped ceramic–metal composites
Authors: Yönetken Ahmet , Erol Ayhan , Peşmen Günnur 
Published: August 2022

Abstract
Titanium is known to be an indispensable element in biomaterials. In this study, boron carbide was considered as an alternative to titanium due to its good mechanical properties. Boron carbide has high temperature resistance, high wear resistance, etc. It is a preferred material due to its properties. Considering this information, different compositions were created by mixing Fe–B4C and egg shell powders. Compositions sintered using powder metallurgy technique were investigated mechanically, physically and metallographically. According to the results of the analysis, it was determined that the hardness increased by 13.75% with the addition of egg shell. The hardness value of 204.12 HB was measured in the sample sintered at 1,400°C by adding 6.66% egg shelter powder.
On a first-order differential system with initial and nonlocal boundary conditions
Authors: Ngoc Le Thi Phuong , Long Nguyen Thanh 
Published: August 2022

Abstract
This paper is devoted to the existence of solutions and the multiplicity of positive solutions of an initial-boundary value problem for a nonlinear first-order differential system with nonlocal conditions. The main tool is the fixed-point theorem in which we construct the novel representation of the associated Green’s functions with useful properties and define a cone in the Banach space suitably. Some examples are also given to demonstrate the validity of the main results.
NMT verb rendering: A cognitive approach to informing Arabic-into-English post-editing
Authors: Almanna Ali , Jamoussi Rafik 
Published: August 2022

Abstract
Machine translation (MT) has made significant strides and has reached accuracy levels that often make the post-editing (PE) of MT output a viable alternative to manual translation. However, despite professional translators increasingly considering PE as a valid stage in their translation workflow, little has been done to investigate MT output for the purpose of informing training in PE. Against this background, the present project focuses on the handling of tense and aspect configurations in the English translation of Arabic sentences using current neural machine translation (NMT) systems. Using a dataset of representative Arabic sentences, the output of five NMT engines was assessed against reference translations. The investigation reveals regressing accuracy levels when comparing morphological, structural, and contextual tenses. These findings are believed to represent valuable information that contributes to a more informed training in the PE of Arabic-into-English NMT output.