bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of skeletal myogenesis in C2C12 cells through modulation of Pax7, MyoD, and myogenin via different low-frequency electromagnetic field energies
Authors: Bi Jiaqi , Jing Hong , Zhou ChenLiang , Gao Peng , Han Fujun , Li Gang , Zhang Shiwei 
Published: February 2022

BACKGROUND: A low-frequency electromagnetic field (LF-EMF) exerts important biological effects on the human body. OBJECTIVE: We previously studied the immunity and atrophy of gastrocnemius muscles in rats with spinal cord injuries and found that LF-EMF with a magnetic flux density of 1.5 mT exerted excellent therapeutic and preventive effects on reducing myotubes and increasing spatium intermusculare. However, the effects of LF-EMF on all stages of skeletal myogenesis, such as activation, proliferation, differentiation, and fusion of satellite cells to myotubes as stimulated by myogenic regulatoryfactors (MRFs), have not been fully elucidated. METHODS: This study investigated the optimal LF-EMF magnetic flux density that exerted maximal effects on all stages of C2C12 cell skeletal myogenesis as well as its impact on regulatory MRFs. RESULTS: The results showed that an LF-EMF with a magnetic flux density of 2.0 mT could activate C2C12 cells and upregulate the proliferation-promoting transcription factor PAX7. On the other hand, 1.5 mT EMF could upregulate the expression of MyoD and myogenin. CONCLUSION: LF-EMF could prevent the disappearance of myotubes, with different magnetic flux densities of LF-EMF exerting independent and positive effects on skeletal myogenesis such as satellite cell activation and proliferation, muscle cell differentiation, and myocyte fusion.
Study of the advantages and risks of electronic retail trade in medicines
Authors: Комаріда О. О. , Убогов С. Г. , Суртаєва Н. В. , Тодорова В. І. , Федорова Л. О. 
Published: February 2022

One of the most important issues of interest to scientists and practitioners of pharmacy is medicines quality assurance at all stages of their life cycle. From 2021 in Ukraine, the retail trade of medicines via the Internet was allowed. The system of electronic (distance) retail trade (ERT) has its obvious advantages for consumers of pharmaceutical services, but also its potential risks for the medicines quality being sold.
The aim of the study is analysis of legislative innovations on ERT in medicines, determination of advantages and possible problems of ERT in medicines, identification of potential risks to the medicines quality during ERT and determination of organizational and practical measures to prevent and minimize them.
The research materials were scientific publications, legislative and regulatory acts of Ukraine and the EU, public information of public authorities and pharmaceutical enterprises, data from own observations. The following methods were used in the work: system and content analysis, generalization, systematization, structural-logical, visual-graphic.
The analysis of sources of scientific and professional literature showed that domestic and foreign scientists have studied the legal, socio-economic and marketing aspects of ERT in medicines. We studied this issue from the standpoint of quality assurance and risk management for the medicines quality.
The paper provides a system and content analysis of legislative innovations on ERT in medicines, summarizes and systematizes the general and special requirements for the procedure for ERT in medicines, identifies the advantages and possible problems of ERT in medicines. The structural and logical scheme of the ERT in medicines process is developed. It is proposed to use this scheme as a basis for the regulation and documentation of the ERT in medicines process by developing appropriate regulatory and instructional documents (regulations or techniques for performing the process, standard operating procedures, work instructions, etc.).
According to the research results, the potential risks for the medicines quality in the conditions of ERT are identified and the complex of organizational and practical measures for their prevention and minimization is determined. It is proposed to implement this complex in the overall risk management process for the medicines quality and pharmaceutical services, which should be an integral part of the quality management system of the pharmaceutical enterprise that performs ERT in medicines. These measures should be taken into account when developing standard operating procedures for different stages of ERT in medicines and documentation on risk management for the medicines quality (passports of risk profiles, risk register, risk management plan, etc.).
Analysis of extemporal production trends in pharmacies for children
Authors: Заліська О. М. , Качерай Ю. В. , Заболотня З. О. , Семенов О. М. 
Published: February 2022

Medicines for children are insufficiently represented in pediatric dosages and appropriate dosage forms in the pharmaceutical market of Ukraine. Pediatricians are forced to prescribe children's medicines in dosages that are not available in the State Register of Medicines of Ukraine. Extemporaneously compounded medicines (ECM) are useful when a required dose or dose form is unavailable commercially, or is needed for individualised dosing.
The aim of the study was to analysis a real data of the list of medicines which are produced in hospital and public pharmacies of Lviv region during 2020–2021.
Methods. Content analysis of extemporal prescriptions for children, depending on the composition of the active pharmaceutical ingredient, dose and dosage form, comparative cost analysis of ECM and industrial medicines.
In the hospital doctors prescribe ECМ in liquid forms (75%) – solutions for injection and in solid forms (25%) – dosed simple powders – 19%, dosed complex powders – 6%. It was determined the structure of ECM, which are produced in 6 studied pharmacies in 2020–2021. There are soft ECM 61.6% in dosage forms: ointments, creams, paste; liquid ECM are 28.3% in mixtures, solutions, mumbles; solid ECM are 8.3% in mono, combine powders, suppositories and 1.8% – other ECM: powders and nail polishs. There were highlighted unique recipes of ECM which analogues were not present in industrial dosage forms.
We conducted analysis of the cost of children’s ECM in these pharmacies. It was determined that ECM cost were 40.5–305.6 UAH depending on the dosage form. The comparative analysis showed that ECM are in 2.2–4.9 times more cheaper for children compare with similar active ingredients in industrial medicines.
ECMs are much more compliant for treatment in children and babies, they provide higher effect, safety, reduce dosing errors, especially at the inpatient stage, and continuation of therapy on an outpatient basis and more cost-effective for individual needs. The use of ECMs allows parents to properly dose them for children, to avoid errors in dosing, improper administration, which is extremely important to ensure the rational use of medicines in pediatric practice.
Study of physicochemical characteristics of calcium hydroxyapatite «Kalident Powder 100» in the development of dental medicine
Authors: Маслій Ю. С. , Крива К. В. , Ковалевська І. В. , Рубан О. А. , Ляпунова О. О. 
Published: February 2022

Despite the development of the dental industry, the prevalence of dental hypersensitivity does not decrease but increases at a progressive rate. Given the above, the subject of our research was the development of dental medicinal films with micronized calcium hydroxyapatite under the trade name «Kalident Powder 100» (Kalichem, Italy) for the treatment of dental hyperesthesia and caries prevention. To establish the optimal method of calcium hydroxyapatite introduction into the dental film, it was necessary to study the influence of different dispersion mediums on the physicochemical characteristics of the substance under study.
Purified water, ethyl alcohol 96%, polysorbate 80, glycerol, polyethylene oxide-400, propylene glycol, sunflower oil, vaseline oil were used as dispersion medium in the studies. Research of physico-chemical characteristics was performed both for the substance «Kalident Powder 100» separately and for its mixtures with the studied liquids and their combinations (in a ratio of 1:1). The following physico-chemical characteristics have been determined: disperse and diffraction analysis of particle size distribution, morphological description, linear dimensions, shape factor, volume coefficient, Martin and Ferret diameters, wettability.
The results of crystallographic and disperse analysis have revealed the polydispersity of the substance «Kalident Powder 100» and its high ability to agglomerate, which may adversely affect the homogeneity of its distribution in the dental medicinal product. A study of the effect of different dispersion medium on the physicochemical characteristics of calcium hydroxyapatite has shown a positive effect of hydrophilic liquids on the wettability of powder particles, changes in their shape, size, and distribution in the studied samples. It has been established that the combination of the substance «Kalident Powder 100» with combined solvent systems containing purified water, polysorbate 80, glycerol, and PEO-400, allows achieving optimal shape and particle size of calcium hydroxyapatite with their uniform distribution throughout the liquid, which is also confirmed by the results of laser diffraction. The obtained results will be used in further research on the development of dental medicinal film.
Investigation of anatomical signs of canadian goldenrod herbs, introduced in Ukraine
Authors: Гонтова Т. М. , Руденко В. П. , Гапоненко В. П. , Козира С. А. , Романова С. В. 
Published: February 2022

The monograph «Goldenrod» SPhU 2.0 describes the general morphological and anatomical features of two species – Solidago gigantea Ait and Solidago canadensis L., which are similar. Not all diagnostic signs can be identified in powdered raw materials. It was important to investigate domestic series of сanadian goldenrod and to identify additional diagnostic signs.
The aim of the work was to study the series of domestic raw materials of сanadian goldenrod by anatomical features and to determine the totality of individual features of the species to establish the identity of raw materials.
The object of the study were samples of сanadian goldenrod grass, which were harvested in August 2020 in the regions of Ukraine. We used an iPhone XR camera, Item PB-2610 V microscope.
Important features of the anatomical structure of the raw material of сanadian goldenrod include: the cells of the stem epidermis are parenchymal, ortho-walled, porous, the leaves – sinuous- and ortho-walled. The presence in the pubescence of stems and leaves 3 types of hairs: simple long, 5–8-celled (up to 20), with thickened walls and pointed cell; short, 2–3-celled, with a dormant apical cell; short and headed with a 2–3-celled stalk and a rounded unicellular head; on the surface and edge of the leaves of the involucre – simple short and 3–4-cell hairs, corollas of flowers – multicellular double-row hairs; stem vessels are spiral, ladder, porous and reticulate; schizogenous structures in the stems, leaves and leaves of the involucre; sphenocrystals of inulin in the parenchyma and vessels of the stem, the cells of the corollas of flowers.
A series of domestic raw materials of сanadian goldenrod has been studied according to anatomical features, a set of individual features of the species has been determined. The obtained results can be used in plant taxonomy for comparative analysis of morphologically similar species of the genus Zolotushnik, as well as to supplement the section «Identification B» of the monograph SPhU 2.0 «Zolotushnik».
Tagállami integrációs modellek
Authors: Czucziné Keresztes Anita 
Published: February 2022

Valamennyi tagállamra azonos szabályok vonatkoztak az európai integráció Maastricht előtti unitárius szerkezetében. Többsebességű integráció lehetséges a Gazdasági és Monetáris Unió rendszerében: különféle kormányzási modellek, bonyolult intézményi feltételek állnak fenn. Milyen változásokat hozhatna az „európai gazdasági kormányzás”, illetve a „teljes” gazdasági unió kiépítése az EU intézményi szerkezetében? Hogyan alakulna e körülmények között az euróövezetbe tartozó, illetve az abból kimaradó tagállamok helyzete? Milyen eltérések lehetnek az egyes tagállamok között az uniós szabályok alkalmazásában? Milyen szerepet tölthet be a megerősített együttműködés a tagállamok szűkebb csoportjának mélyebb integrációjában? Hogyan alakulhat a mediterrán periféria, illetve a közép- és kelet-európai „új tagállamok” pozíciója? Többek között a fenti kérdésekre is választ kapunk a kötetben.
MENINGKATKAN KEMAMPUAN PETUGAS RUMAH SINGGAH IZI DALAM “TARGET SEHAT MANDIRI” MELALUI MINDFULNESS SPIRITUAL
Authors: Ulliya Sarah , Dwidiyanti Meidiana , Wijayanti Diyan Yuli , Muin Muhammad , Sulisno Madya 
Published: February 2022

Mindfulness merupakan kesadaran individu terhadap pengalaman yang dialami, dengan memberi perhatian yang penuh, dan menerima tanpa memberikan penilaian. Hanya berfokus terhadap apa yang sedang di kerjakan oleh individu sebagai upaya untuk dapat menolong dan menyelesaikan masalahnya sendiri secara mandiri (selfcare). Mindfulness sehat mandiri ini dapat dilakukan oleh pasien dengan masalah Kesehatan yang kronis, seprti pasien kanker dan leukemi. Pasien dirumah Singgah IZI merupakan pasien yang sebagian terdiagnosis cancer dan leukemia yang tidak mempunyai biaya dalam pengobatan dirumah sakit.. Target sehat mandiri adalah keterampilan atau skill yang seharusnya dimiliki oleh pasien misalnya cara mengatasi rasa sakit, cara mengatasi rasa marah, cara mengatasi kesedihan, cara mengatasi gangguan makan dan tidur termasuk cara bersosialisasi dengan orang lain. Diperlukan ketrampilan tambahan bagi pegawai /caregiver di rumah singgah dalam menghadapi pasien di rumah singgah IZI, sehingga dapat menolong atau mendukung kesembuhan pasien. Tujuan pelaksanaan pengabdian ini untuk meningkatkan kemampuan caregiver dalam mengelola keluhan pasien. Metode pelaksanaan dengan memberikan latihan target sehat mandiri sebanyak 3 kali pertemuan. Pelaksanaan kegiatan dilaksanakan di Rumah Singgah IZI dengan melibatkan pegawai dan caregiver Rumah Singgah IZI. Hasil dari pengabdian ini adalah peserta pelatihan merasakan manfaatnya, merasa nyaman, tenang selama mempraktikan mindfulness spiritual. Evaluasi praktik mindfulness; terdapat beberapa respon emosi, fisik dan spiritual yang dirasakan oleh peserta. Rencana Tindak lanjut adalah caregiver dan petugas dapat mengajarkan dan memandirikan pasien di rumah singgah dengan mindfulness target sehat mandiri, sehingga pasien dengan masalah Kesehatan kronik dapat melakukan secara mandiri
MASJID NABAWI SEBAGAI DASAR PEMBENTUKAN MASJID AGUNG KRATON SURAKARTA
Authors: Hermanto Heri , Hidayah Atinia 
Published: February 2022

ABSTRACT
Prophet Muhammad was the architect and ground-breaking stone for the construction of the Prophet's Mosque or an-Nabawi in Medina in 622. The Prophet's Mosque was established with a very simple design yet it owns beneficial functions. The Prophet's Mosque is a place often used for various purposes for instance as government centers, learning centers, medical treatment place, detention and rehabilitation centers, and certainly more social or worshipping center. Building designed with a simple form but rich in functions had never existed before. Therefore, Prophet's Mosque had become the basis, inspiration, and catalyst for the development of Islamic civilization especially mosque architecture.
The architecture of the mosque then became the most important identity for the progress of Muslims. The essence of Muslim architecture lies in function with all of its dimensions including the physical, intellectual, and spiritual aspects. The role of form is also important, but only insofar as it complements and enhances function. There are four typical mosques that are considered to represent the heritage of Islamic architecture in this world which were inspired by the Prophet's Mosque, namely; Arabic Type, Turkish Type, Persian Type, and Indian Type. This typology does not include the type of Indonesian mosque, even though the mosques built by Walisongo and the kings of Islamic Mataram in Java are no less great and unique compared to other famous mosques in the world. The question that then emerges is whether or not the Prophet's Mosque is the basis and inspiration for the realization of the Architecture of the Great Mosque of Keraton Surakarta.
Produção de cerveja artesanal com pimenta dedo-de-moça comercial
Authors: Castro Thiago Luis Aguayo de , Santos Maria do Socorro Mascarenhas , Cardoso Claudia Andrea Lima 
Published: February 2022

A produção de cervejas artesanais tem crescido. A adição de plantas com potencial antioxidante é uma alternativa para aumentar a estabilidade dos produtos. A pimenta, conhecida popularmente como dedo-de-moça (Capsicum baccatum), é comercializada e apresenta potencial antioxidante. Neste cenário, foi produzida a cerveja artesanal com adição de pimenta dedo-de-moça a 0,1% (m/v) (CCP) e a cerveja produzida pelo mesmo método sem adição de pimenta (CSP). Foram avaliados os parâmetros pH, cor, teor alcoólico, potencial antioxidante e teor de compostos. Com exceção da cor, cujo valor médio foi igual para CCP e CSP, todos os demais parâmetros apresentaram diferenças significativas entre CCP e CSP com p <0,05. A CCP apresentou uma concentração mais elevada de etanol, com teor alcóolico de 5,58 ± 0,17 %, enquanto que a CSP apresentou 5,00 ± 0,09% e também maior teor de compostos fenólicos e de potencial antioxidante. Os resultados indicam que há perspectiva positiva para o uso de pimenta “dedo-de-moça” na produção de cervejas. Neste sentido, é necessário analisar sensorialidade e estabilidade do produto durante o armazenamento.
A etnobotânica como influenciadora da prospecção farmacológica
Authors: Sganzerla Camila Mabel , Predebon Ana Júlia , Veloso Jaqueline Janaine , Roman Junior Walter Antônio 
Published: February 2022

A utilização de plantas com fins medicinais, para o tratamento, a cura e a prevenção de doenças, é uma das mais antigas formas terapêuticas da humanidade[1]. Como consequência, nas últimas décadas tem se observado um aumento significativo de pesquisas sobre as relações das comunidades com os recursos biológicos. Estes estudos têm contribuído para a recuperação de saberes, práticas e, também, servido para avançar no autoconhecimento sociocultural dessas populações. Abordagens científicas nessa direção, têm buscado compreender, dentre outros aspectos, como são utilizadas as plantas medicinais por comunidades que incluem, nessa vertente, as pesquisas etnobotânicas[2,3].
A etnobotânica tem sido definida como um estudo capaz de compreender as interrelações entre o homem e as plantas e, o modo como as plantas são utilizadas para os mais diversos recursos[1]. Permite um melhor entendimento das formas pelas quais as pessoas pensam, classificam, controlam, manipulam e utilizam espécies de plantas nas comunidades [4,5]. Trata de mostrar que existem práticas alternativas capazes de se tornar parte de um processo renovado e complementar para promover saúde. Meios, por vezes, não lucrativos e menos onerosos de cuidar do ser humano em sua totalidade[6]. Assim, a manutenção desse conhecimento por meio de gerações sucessivas, pode ser utilizada como uma ferramenta importante para os futuros estudos fitoquímicos, farmacológicos e toxicológicos bem como, para a conservação histórica e cultural[5]. No entanto, apesar da variedade de biomas que refletem a enorme flora brasileira, aliada uma miscigenação de etnias e enorme diversidade cultural, um número reduzido de comunidades tem desenvolvido pesquisas etnobotânicas, e são escassos os estudos que realizaram investigações acerca das práticas populares de cura. Nessa perspectiva, este trabalho objetivou realizar um levantamento etnobotânico de plantas medicinais no município de Guatambu (SC), com foco na relevância para as futuras pesquisas de bioprospecção nesta região de imigrantes inserida na Mata Atlântida.
"É preciso estar atento e forte!"
Authors: Fontes Barbara 
Published: February 2022

Chegamos ao final do ano de 2021 e, ainda em meio à pandemia de COVID-19, abrimos a 28ª edição da Perspectiva Sociológica: A revista de professores de Sociologia prestando nossa solidariedade às famílias, amigos e amores das mais de 617 mil vítimas da doença no Brasil. Apesar da condução negacionista e criminosa da atual gestão do país em relação à pandemia, a ampliação da vacinação no Brasil sinaliza tempos melhores com a redução do número de casos, internações e óbitos em consequência da doença.Nesse contexto, acompanhamos as redes de ensino básico e superior voltando gradativamente ao ensino presencial. Em meio à felicidade de retornarmos ao ambiente escolar e de restabelecermos as relações que enchem de sentido a prática docente, permanecemos alertas e resistentes no que se refere à implementação do Novo Ensino Médio, a partir do ano de 2022. Como dissemos na apresentação da edição passada, além de potencializar as já marcantes desigualdades educacionais, essa Reforma Educacional vulnerabiliza ainda mais a já frágil e intermitente presença da sociologia na grade curricular do Ensino Médio. No entanto, como nos ensinam os movimentos sociais e a bela canção de Caetano Veloso, o título desta edição é: “É preciso estar atento e forte!”. As leitoras e os leitores verão que há diversas formas de resistir e mostrar a força e importância da disciplina escolar Sociologia.
The ECO-FERMENTASI DAN APLIKASINYA PADA LAHAN MARGINAL DI DESA REULEUT BARAT ACEH UTARA
Authors: Abdul Gani Rosnina , Wirda Zurrahmi , Nilahayati  , Sartika A Dewi 
Published: February 2022

ABSTRACT
Reuleut Barat is a village assisted by Malikussaleh University which is classified Inceptisol soil as sub-optimal land that has a low pH and comes from low of organic matter. The low quality of land in the West Reuleut area as marginal land that is less productive has an impact on the low income and welfare of its people. The limitations of productive land can be overcome by the application of biotechnology innovations by utilizing microorganisms through the application of organic fertilizers. Organic fertilizers can be obtained from a waste processing process known as the 3R (reuse, reduce and recycle). Making eco-fermentation is done by sorting household waste as an initial step in producing organic fertilizer by processing vegetable waste materials such as fruit peels such as papaya, pineapple, oranges which are added with molasses as an activator of microorganisms in the fermentation process so that the final product obtained is a liquid that is easy to use in its application to the ground. The application of Eco-fermentation fertilizers as organic materials containing microflora has a role in increasing the activity of marginal soil microorganisms into productive land through the weathering process of soil organic matter which can improve the physical, chemical, and biological properties of the soil so that ultimately it can increase soil fertility which can increase crop production of Reuleut Barat village.
Keywords: eco-fermentation, sub-optimal land, organic-waste