bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term Music Therapy for Families With Preterm Infants: A Randomized Trial
Authors: Gaden Tora Söderström , Ghetti Claire , Kvestad Ingrid , Bieleninik Łucja , Stordal Andreas Størksen , Assmus Jörg , Arnon Shmuel , Elefant Cochavit , Epstein Shulamit , Ettenberger Mark , Lichtensztejn Marcela , Lindvall Merethe Wolf , Mangersnes Julie , Røed Catharina Janner , Vederhus Bente Johanne , Gold Christian 
Published: January 2022

OBJECTIVESTo evaluate short-term effects of music therapy (MT) for premature infants and their caregivers on mother-infant bonding, parental anxiety, and maternal depression.METHODSParallel, pragmatic, randomized controlled-trial conducted in 7 level III NICUs and 1 level IV NICU in 5 countries enrolling premature infants (&lt;35 weeks gestational age at birth) and their parents. MT included 3 sessions per week with parent-led, infant-directed singing supported by a music therapist. Primary outcome was mother-infant bonding as measured by the Postpartum Bonding Questionnaire (PBQ) at discharge from NICU. Secondary outcomes were parents’ symptoms of anxiety measured by General Anxiety Disorder-7 (GAD-7) and maternal depression measured by Edinburgh Postpartum Depression Scale (EPDS). Group differences at the assessment timepoint of discharge from hospital were tested by linear mixed effect models (ANCOVA).RESULTSFrom August 2018 to April 2020, 213 families were enrolled in the study, of whom 108 were randomly assigned to standard care and 105 to MT. Of the participants, 208 of 213 (98%) completed treatment and assessments. Participants in the MT group received a mean (SD) of 10 sessions (5.95), and 87 of 105 participants (83%) received the minimum of 6 sessions. The estimated group effect (95% confidence interval) for PBQ was −0.61 (−1.82 to 0.59). No significant differences between groups were found (P = .32). No significant effects for secondary outcomes or subgroups were found.CONCLUSIONSParent-led, infant-directed singing supported by a music therapist resulted in no significant differences between groups in mother-infant bonding, parental anxiety, or maternal depression at discharge.
Medicine and athletics evolution
Authors: Usanova A. A. , Kunyaeva T. A. , Goncharova L. N. , Pushkina Ya. A. , Radaikina O. G. , Guranova N. N. , Fazlova I. Kh. , Sergutova N. P. , Dyachkova A. A. 
Published: January 2022

The article discusses the most popular type of Olympic movement — athletics. All stages of athletics formation and development are highlighted and described.A connection from ancient athleticism to modern Olympism is described, including the problem of globalization of sports and medical supervision.From the very beginning, athletics has established itself as an international sport in which men and women from all over the world participate.New trends of the late XX — early XXI century have a serious impact on various areas of modern life, including the sports industry and the Olympic movement.The communication revolution has brought not only benefits, but also created new problems. Based on the study of athletics development, it has been established that the Olympic movement remains an important international institution working to strengthen mutual understanding and cooperation between peoples.Further, the International Olympic Committee notes the expansion of educational work to spread the Olympic values and ideals of sport.The article is devoted to topical issues of the Olympic movement, which have a significant impact on social processes.
Fatores comunicacionais para elaboração de produtos/processos educativos em Programas Profissionais de Pós-graduação na área de Ensino/Educação em Ciências e Matemática: reflexões emergentes e em movimento
Authors: Cordeiro Robson Vinicius , Altoé Renan Oliveira 
Published: January 2022

Na produção de produtos/processos educacionais dos Programas Profissionais de Pós-graduação, percebemos a existência de um movimento de reflexão acerca da materialização e virtualização desses materiais. Assim, este trabalho apresenta alguns fatores e elementos que podem constituir o diálogo comunicacional dos produtos/processos educativos da área de Ensino, transparecendo suas perspectivas conceituais e pedagógicas, auxiliando discentes e docentes nas suas produções, a fim de qualificá-las e de ampliar condições de acesso e utilização por parte da comunidade em geral. A partir de uma abordagem qualitativa, em diálogo com uma pesquisa bibliográfica, nossas reflexões culminaram na construção de cinco fatores (Materialidade, Linguagem, Estética, Usabilidade e Publicidade), como componentes do Eixo Comunicacional, revelando uma preocupação que está para além de determinações superficiais dos produtos/processos educativos.
Letramentos e mediação da tecnologia digital
Authors: Baranauskas Maria Cecília Calani , Valente José Armando 
Published: January 2022

Esta edição resulta do fluxo aberto e regular de submissões, avaliações e revisões de artigos científicos, relatos de experiência e resumos estendidos de teses e dissertações. Neste volume, a revista inclui 05 trabalhos assim distribuídos: três artigos científicos e dois relatos de experiência. As contribuições deste volume foram escritas por autores atuantes na comunidade brasileira de informática na educação, originários de instituições de cinco diferentes estados da federação (PR, RN, RO, RS, SP). Os trabalhos envolvem questões da informática na educação nos três níveis (Fundamental I, Fundamental II e Ensino Médio) e nos espaços educativos formais e não formais.
Ocean climate connectivity and the future range shifts of marine biodiversity.
Authors: Petsas Panagiotis , Doxa Aggeliki , Almpanidou Vasiliki , Mazaris Antonios D. 
Published: January 2022

Abstract
Shifting distribution to track suitable climate is a potential strategy for marine species to cope with ocean warming. Yet, the ability of species to successfully reach future climate analogs largely depends on the length of the paths that connect them, and on the exposure of these paths to extreme climates during this transition. Here, we evaluate marine climate connectivity for trajectories between climatic analogs on a global scale. We find that while movement between climatic analogs is more intense in the northern seas of the planet, they require longer trajectories to reach climatic analogs, with high climatic exposure to extreme conditions. On the contrary, the southern seas host areas that have closer climatic analogs, further subjected to a lower exposure to dissimilar climates. These patterns are mirrored in the connectivity properties of the global marine protected areas, highlighting sites which might fail to facilitate connectivity to future climates. Our results suggest that potential shifts between climatic analogs might be subjected to more limitations than those suggested by previous studies, with marine connectivity offering novel insights for the establishment of climate-wise conservation future networks.
Comparison of Tumor Immune Environment Between Newly Diagnosed and Recurrent Glioblastoma in Matched Patients
Authors: Wang Fei , Cathcart Sahara J , DiMaio Dominick J , Zhao Nan , Chen Jie , Aizenberg Michele R , Shonka Nicole A , Lin Chi , Zhang Chi 
Published: January 2022

Abstract
Purpose: Glioblastoma (GBM) is the most lethal primary brain tumor in adult patients. The disease progression, response to chemotherapy and radiotherapy at initial diagnosis, and prognosis are profoundly associated with the tumor microenvironment (TME), especially the features of tumor-infiltrating immune cells (TII). Recurrent GBM is even more challenging to manage. Differences in the immune environment between newly diagnosed and recurrent GBM and an association with tumor prognosis are not well defined. Methods: To address this knowledge gap, we analyzed the clinical data and tissue specimens from 24 GBM patients (13 at initial diagnosis and 11 at recurrence). The expression levels of multiple immunobiological markers in patients’ GBM at initial diagnosis versus at recurrence were compared, including five patients with both specimens available (paired). The distribution patterns of TII were evaluated in both the intratumoral and perivascular regions. Results: We found that tumors from recurrent GBM have significantly more tumor-infiltrating lymphocytes (TILs) and macrophages and higher PD-L1 expression than tumors at primary diagnosis and benign brain specimens from epilepsy surgery. The pattern changes of the TILs and macrophages of the five paired specimens were consistent with the unpaired patients, while the CD8 to CD4 ratio remained constant from diagnosis to recurrence in the paired tissues. The levels of TILs and macrophages at initial diagnosis did not correlate with OS. TILs and macrophages were increased in recurrent tumors both in intratumoral and perivascular areas, with higher distribution levels in intratumoral than perivascular regions. Higher CD4 or CD8 infiltration at recurrence was associated with worse prognosis, respectively. Conclusion: Our study elucidated that TIL and TAM tend to accumulate in perivascular region and are more abundant in recurrent GBM than newly diagnosed GBM.
Quantum harmonic free energies for biomolecules and nanomaterials
Authors: White Alec , Li Chenghan , Chan Garnet Kin-Lic 
Published: January 2022

Abstract
Obtaining the free energy of large molecules from quantum mechanical energy functions is a longstanding challenge. We describe a method that allows us to estimate, at the quantum mechanical level, the harmonic contributions to the thermodynamics of molecular systems of unprecedented size, with modest cost. Using this approach, we compute the vibrational thermodynamics of a series of diamond nanocrystals, and show that the error per atom decreases with system size in the limit of large systems. We further show that we can obtain the vibrational contributions to the binding free energies of prototypical protein-ligand complexes where the exact computation is too expensive to be practical. Our work raises the possibility of routine quantum mechanical estimates of thermodynamic quantities in complex systems.
Nanometric transverse displacement metrology in range of hundreds of micrometers with polarization-encoded metasurface
Authors: Zang Haofeng , Xi Zheng , Zhang Zhiyu , Lu Yonghua , Wang Pei 
Published: January 2022

Abstract
A long range, high precision and compact transverse displacement metrology method is of crucial importance in many research areas. We propose and experimentally demonstrate the first prototype polarization-encoded metasurface for ultrasensitive transverse displacement metrology. The transverse displacement of the metasurface is encoded into the polarization direction of the outgoing light via the Pancharatnam-Berry phase. By measuring the output light polarization direction, the metasurface’s position can be readout directly according to the Malus law. We experimentally demonstrate nanometer displacement resolution with the uncertainty on the order of 100 pm for a large measurement range of 200 µm with the total area of the metasurface being within 900 µm x 900 µm. The measurement range can be extended further using a larger metasurface. Our work largely broadens the existing application areas of metasurface and opens new avenue of applying metasurface in the field of ultrasensitive optical transverse displacement metrology.
Evolution of Surgical Treatment of Metastatic Spine Tumors.
Authors: Sullivan Patricia Zadnik , Niu Tianyi , Abinader Jose Fernandez , Syed Sohail , Sampath Prakash , Telfeian Albert , Fridley Jared , Klinge Petra , Camara Joaquin , Oyelese Adetokunbo , Gokaslan Ziya 
Published: January 2022

Abstract
Purpose
The treatment of cancer has transformed over the past forty years, with medical oncologists, radiation oncologists and surgeons working together to prolong survival times and minimize treatment related morbidity. With each advancement, the risk-benefit scale has been calibrated to provide an accurate assessment of surgical hazard. The goal of this review is to look back at how the role of surgery has evolved with each new medical advance, and to explore the role of surgeons in the future of cancer care.
Methods
A literature review was conducted, highlighting the key papers guiding surgical management of spinal metastatic lesions.
Conclusion
The roles of surgery, medical therapy and radiation have evolved over the past forty years, with new advances requiring complex multidisciplinary care.
Perceived Barriers, Benefits, Facilitators, and Attitudes of Health Professionals Towards Type 2 Diabetes Management in Oujda, Morocco: A Qualitative Focus Group Study
Authors: Dankoly Usman Sani , Vissers Dirk , Mostafa Souad Ben El , Ziyyat Abderrahim , Rompaey Bart Van , Royen Paul Van , Maamri Abdellatif 
Published: January 2022

Abstract
Background: In Morocco, the treatment of type 2 diabetes (T2D) is mainly focused on medication and only 2% of patients are coached towards a healthier lifestyle. In Oujda, Eastern Morocco the prevalence of T2D is 10.2%, and the current trend is alarming, especially for women. Therefore, the aim of this study is to explore healthcare professionals' (HCP) views about the perceived barriers and benefits towards an integrated care approach in primary healthcare centers (PHCCs) to T2D management in Oujda.Methods: A descriptive study using focus groups in 8 PHCCs. This resulted in a sample of 5 doctors and 25 nurses caring for diabetes patients. The transcripts of all conversations were coded to allow for thematic analysis.Results: The participants mentioned different barriers to an integrated approach of DM management:: excessive workload; poor reimbursement policy; lack of staff and equipment; interrupted drug supply; poor working environment; limited referral; gap in the knowledge of general practitioners; health beliefs; poverty; advanced age; gender; the use of psychotropic drugs. An integrated approach could be facilitated by simplified electronic records and referral; uninterrupted free care; staff recruitment; continuous professional development; internships. Benefits: structured care; promotion of care in PHCCs; empowerment of self-management.Conclusion: HCP views reflect the urge to strengthen the management of T2D in PHCCs. There is a need for HCP with expertise in physical activity and nutrition to solve the current gap in the multidisciplinary integrated care approach. The specific local context can contribute to patients' reluctance to change their lifestyles and is a challenge to provide care in an efficient and sustainable manner. More research is needed to see how a patient-centered multidisciplinary approach to T2D management can help motivate patients in Morocco to change to a healthier lifestyle.
Does China’s Fertility Policy Induce Employment Discrimination Against Women? Evidence from a Nationwide Correspondence Experiment
Authors: Li Xun , Wen Dan , Ye Lin , Yu Jiang 
Published: January 2022

Abstract
We apply a two-wave nationwide correspondence experiment to assess the effects of the two-child and three-child policies in China. Using 13,751 observations collected through this experiment, we find that the announcement of the two-child policy led to a 4.9% decrease in total interview callbacks overall, and decreases of 4.3%, 5.7%, and 5.6% for single women, those married with no children, and those married with one child, respectively. The implementation of the three-child policy led to a 10.4% decrease, but only for married women with two children. The discrimination broadly affected all women, whether they disclose marriage and fertility status information or not, as we find their callback rates decreased by 4.5% under the universal two-child policy and 6.6% after the three-child policy.
LRRC15 suppresses SARS-CoV-2 infection and controls collagen production
Authors: Loo Lipin , Waller Matthew , Cole Alexander , Stella Alberto , Moreno Cesar , Denes Christopher , Hamoudi Zina , Chung Felicity , Aggarwal Anupriya , Low Jason , Patel Karishma , Siddiquee Rezwan , Mackay Joel , Turville Stuart , Hesselson Daniel , Neely G. 
Published: January 2022

Abstract
Although ACE2 is the primary receptor for SARS-CoV-2 infection, a systematic assessment of factors controlling SARS-CoV-2 host interactions has not been described. Here we used whole genome CRISPR activation to identify host factors controlling SARS-CoV-2 Spike binding. The top hit was a Toll-like receptor-related cell surface receptor called leucine-rich repeat-containing protein 15 (LRRC15). LRRC15 expression was sufficient to promote SARS-CoV-2 Spike binding where it forms a cell surface complex with LRRC15 but does not support infection. Instead, LRRC15 functioned as a negative receptor suppressing both pseudotyped and live SARS-CoV-2 infection. LRRC15 is expressed in collagen-producing lung myofibroblasts where it can sequester virus and reduce infection in trans. Mechanistically LRRC15 is regulated by TGF-β, where moderate LRRC15 expression drives collagen production but high levels suppress it, revealing a novel lung fibrosis feedback circuit. Overall, LRRC15 is a master regulator of SARS-CoV-2, suppressing infection and controlling collagen production associated with “long-haul” COVID-19.
Mechanisms of Action of Zishen Yutai pills in Treating Premature Ovarian Failure Determined by Integrating UHPLC-Q-TOF-MS and Network Pharmacology Analysis
Authors: Dang Lei , Zhang Chunbo , Su Biru , Na Ning , Huang Qiuling , Zhou Su , Wu Meng , Ma Wenqing , Wang Man , Cui Pengfei , Li Yan , Wang Shixuan 
Published: January 2022

Abstract
Background: Zishen Yutai (ZSYT) pill, a patent Chinese medicine, has been widely used in the treatment of infertility, abortion, and adjunctive treatment of in vitro fertilization (IVF) for decades. Recently, the results of clinical observations showed that premature ovarian failure (POF) patients exhibited improved expression of steroids and clinical symptoms associated with hormone disorders after treatment with ZSYT pills. However, the pharmacological mechanism of action of these pills remains unclear.Methods: The components of ZSYT found in blood circulation were identified via ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) technique in the serum of POF mice after oral administration of ZSYT pills. The potential targets of components were screened using Traditional Chinese Medicine Systems Pharmacology Database, Traditional Chinese Medicine Database@Taiwan, Drugbank Database, PubChem, HIT, Pharmapper, and SwissTargetPrediction. The target genes associated with POF were collected from Online Mendelian Inheritance in Man Database, PharmGkb, Genecards, therapeutic target database, and Genetic Association Database. The overlapping genes between the potential targets of ZSYT components and the target genes associated with POF were clarified via protein-protein interaction (PPI), pathway, and network analysis.Results: Nineteen components in ZSYT pills were detected in the serum of POF mice after oral administration. A total of 695 ZSYT-related targets was screened, and 344 POF-related targets were collected. From the results of ZSYT-POF PPI analysis, CYP19A1, AKR1C3, ESR1, AR, and SRD5A2 were identified as key targets via network analysis, indicating their core role in the treatment of POF with ZSYT pills. Moreover, the pathway enrichment results suggested that ZSYT pills treat POF primarily by regulating neuroactive ligand-receptor interaction, steroid hormone biosynthesis, and ovarian steroidogenesis.Conclusions: We demonstrated that regulation of neuroactive ligand-receptor interaction, steroid hormone biosynthesis, and ovarian steroidogenesis are very likely to be therapeutic mechanism of ZSYT pills in treating POF. Our study suggests that combining the analysis of ZSYT pills components in blood in vivo in the POF models and network pharmacology prediction may offer a tool to characterize the mechanism of ZSYT pills in the POF.
Elimination of [PSI+] Prion and Influence on Yeast Cell Growth
Authors: Versockienė Justina , Jonutytė-Trembo Neda , Novickij Vitalij , Lastauskienė Eglė 
Published: January 2022

Abstract
Background

Prions are proteinaceous infectious particles that act as pathogens and cause the development of lethal neurodegenerative diseases in humans and other animals. Yeast Saccharomyces cerevisiae is a widespread model system in which mechanisms of prion induction and elimination have been identified. New and safe substances and methods are being sought to cure cells of prion proteins. It is particularly important that by treating cells from prions and restoring them from the [PSI+] to the [psi−] form, the primary growth of the cells is restored. One of the main objectives of this study was to determine the growth dynamics of S. cerevisiae cells with different [PSI+] prion variants, cells that have lost [PSI+] prion variants, and cells that never had [PSI+] prion variants.
Results

In this research, we applied GuHCl and combined GuHCl and PEF treatment against [PSI+] prion. We evaluated cells culture growth dynamics – optical density and doubling time and determined that method of [PSI+] prion elimination does not affect cell doubling time. Also, we found that both elimination methods affect the optical density reached by [psi−] cells. However, the cells in which the [PSI+] prion has been eliminated by GuHCl alone are able to reach the same optical density as unaffected [psi−] cells and higher optical density than the affected [psi−] cells by GuHCl alone.
Conclusions

These findings indicate the potential long-term positive effect of [PSI+] prion on cell growth, which persists after [PSI+] removal.
Inhibitory KIR2DL2 Receptor and HHV-8 in Classic or Endemic Kaposi Sarcoma
Authors: Bortolotti Daria , Corazza Monica , Rotola Antonella , Bencivelli Dario , Schiuma Giovanna , Danese Elisabetta , Rizzo Sabrina , Beltrami Silvia , Rizzo Roberta , Borghi Alessandro 
Published: January 2022

Abstract
KIR2DL2, an inhibitory Killer cell Immunoglobulin-like Receptor (KIR), has been shown to predispose to the development of several herpesvirus-associated diseases by inhibiting the efficiency of Natural Killer (NK) cells against virus-infected cells. The aim of this observational study was to assess the prevalence of KIR2DL2 and Human Herpes Virus 8 (HHV8) in patients affected with classical and endemic Kaposi sarcoma (KS), as well as in controls. Blood samples collected from 17 Caucasian, HIV-negative, immunocompetent patients affected with classical KS (c-KS), 12 African, HIV-negative patients with endemic KS (e-KS), 83 healthy subjects and 26 psoriatic patients were processed for genotypization by PCR for two KIR alleles, such as KIR2DL2 and KIR2DL3 and analyzed for HHV-8 presence. The totality of both c-KS and e-KS patients presented HHV-8 infection, whereas HHV8 was found in 26.9% of psoriatic subjects and 19.3% of healthy subjects. KIR2DL2 was found in the 76.5% of c-KS subjects, while the receptor was found in 41.7% of the e-KS group, 34.6% of psoriatic patients and 43.4% of healthy controls (p<0.0001). A significantly higher prevalence of KIR2DL2 in c-KS patients than in all the other subjects was also confirmed comparing age-matched groups. Based on these results, the inhibitory KIR2DL2 genotype appears to be a possible cofactor which increases the risk of developing c-KS in HHV8-positive, immunocompetent subjects, while it seems less relevant in e-KS pathogenesis.