bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-office needle arthroscopic assessment after primary ACL repair: short-term results in 15 patients
Authors: Annibaldi Alessandro , Monaco Edoardo , Daggett Matthew , Carrozzo Alessandro , Mazza Daniele , Previ Leonardo , Rossi Giorgio , Orlandi Pierfrancesco , Ferretti Andrea 
Published: September 2022

Abstract
Purpose
In-office needle arthroscopy has been reported as a diagnostic tool for different knee pathologies. In addition, ACL repair has seen a resurgence with the advent of innovative orthopedic devices. The aim of this study was to assess clinical, radiological, and in-office needle arthroscopic findings in 15 adult patients who underwent acute (within 14 days from injury) anterior cruciate ligament (ACL) repair.

Methods
Fifteen patients voluntarily participated in the study. A second-look arthroscopy was performed with an in-office needle arthroscopy at an average of 7.2 months after the primary repair. The parameters included in the investigation were the continuity of the anatomical footprint of the repaired ACL, subjective assessment of the ACL tension with the probe, and synovial coverage of the ACL. All patients had a Magnetic Resonance Imaging (MRI) at 6 months after repair and an arthrometric evaluation with the KT-1000. Clinical evaluation with the scores, Tegner Lysholm Knee Scoring Scale (TLKSS), the Knee Injury and Osteoarthritis Outcome Score (KOOS), and International Knee Documentation Committee (IKDC) was performed at the final follow-up of 2 years. Moreover, a correlation between the characteristics of ACL appearance at the time of the second look in-office needle arthroscopy, MRI and KT-1000 was performed.

Results
The mean TLKSS was 97.86, the mean KOOS was 98.08 and the mean subjective IKDC was 96.71. The objective IKDC was A in 10 patients and B in 5 patients. ACL healing was graded as A in 11 patients and B in 4 patients. Synovial coverage was graded as good in 10 patients and fair in 5 while MRI assessment showed a type I ACL in 10 patients, type II in 4 patients and type III in 1 patient.

Conclusion
In-office needle arthroscopy is a reliable tool to assess the condition of a repaired ACL. In addition, ACL repair performed in acute proximal tears demonstrated excellent clinical results.
The impact of patient engagement on trials and trialists in Ontario, Canada: An interview study with IMPACT awardees
Authors: Nicholls Stuart G. , Fox Grace , Monfaredi Zarah , Poole Evelyn , Garritty Chantelle , Maybee Alies , Presseau Justin , Shea Beverley , Fergusson Dean A. 
Published: September 2022

Abstract
Background
A key component of patient-oriented research is the engagement of patients as partners in the design and conduct of health research. While there is now national infrastructure and networks to support the engagement of patients as partners, there remain calls for promising practices and success stories. In particular, there remains a keen interest in evaluating the impact that patient engagement has on health research studies. We aimed to investigate the impact that patient engagement had on health research conducted in Ontario, Canada.

Methods
Our sampling frame was studies that were awarded funding by the Ontario SPOR SUPPORT Unit. Semi-structured interviews were conducted with 10 principal investigators, members of research teams, and patient partners. Interviews explored the role of patient partners, the perceived impact of the patient engagement on the study, challenges faced, and advice for other researchers considering patient engagement. Data were analysed using the thematic analysis method with transcripts coded independently by two members of the study team. All coding and subsequent theme generation were discussed until consensus was achieved.

Results
There was variation in the methods used to engage patients and other stakeholders, the roles that patients and stakeholders occupied, and where they had input. Interviewees discussed two major areas of impact of patient engagement on research: impact on the study about which they were being interviewed, which tended to relate to improved relevancy of the research to the study population, and impact on themselves which led to changes in their own practice or approaches to future research. Identified challenges to patient engagement included: identifying and reaching patient advisors or patient partners, time-related challenges, and maintaining engagement over the course of the research.

Conclusions
There remains a need to further build out the concept of relevancy and how it may be operationalised in practice. Further, the longer-term impacts of patient engagement on researchers and research teams remains under-explored and may reveal additional elements for evaluation. Challenges to patient engagement remain, including identifying and maintaining engagement with partners that reflect the diversity of the population of interest.
Patient-identified priorities for successful partnerships in patient-oriented research
Authors: Santana Maria J. , Duquette D’Arcy , Fairie Paul , Nielssen Ingrid , Bele Sumedh , Ahmed Sadia , Barbosa Tiffany , Zelinsky Sandra 
Published: September 2022

AbstractAlbertans4HealthResearch, supported by the Alberta Strategy for Patient-Oriented Research Patient Engagement Team, hosted a virtual round table discussion to develop a list of considerations for successful partnerships in patient-oriented research. The group, which consists of active patient partners across the Canadian province of Alberta and some research staff engaged in patient-oriented research, considered advice for academic researchers on how to best partner with patients and community members on health research projects. The group identified four main themes, aligned with the national strategy for patient-oriented research (SPOR) patient engagement framework, highlighting important considerations for researchers from the patient perspective, providing practical ways to implement SPOR’s key principles: inclusiveness, support, mutual respect, and co-building. This commentary considers the process behind this engagement exercise and offers advice directly from active patient research partners on how to fulfill the operational patient engagement mandate. Academic research teams can use this guidance when considering how to work together with patient partners and community members.
Factors associated with preventive behaviors for COVID-19 infection among healthcare workers by a health behavior model
Authors: Limkunakul Chutatip , Phuthomdee Sadiporn , Srinithiwat Palakorn , Chanthanaroj Sasinun , Boonsawat Watchara , Sawanyawisuth Kittisak 
Published: September 2022

Abstract
Background
Coronavirus disease 2019 (COVID-19) is a pandemic disease. There are limited data on predictors of good preventive behaviors among healthcare workers. This study aimed to evaluate if any factors were predictors of good preventive behaviors in healthcare workers under the theory of health behavior model.

Methods
This was a cross-sectional study in healthcare workers who were willing to participate in the study. Participants were requested to fill out a self-administered questionnaire that comprised health behavior model and preventive behaviors from COVID-19 infection. Factors associated with preventive behavior, an outcome, were analyzed by multivariate linear regression analysis.

Results
There were 273 healthcare workers who participated in this study. The average (SD) age and working duration of participants was 38.9 (12.1) and 11.4 (9.8) years. The preventive behavior category had an average score of 87.6% (70.3/80). After adjusted, knowledge and perception of personal preventability were independently associated with preventive behaviors. The adjusted coefficients of both factors were—0.911 (p 0.009) and 0.477 (p < 0.001).

Conclusions
Specific knowledge and perception of personal ability questions were associated with preventive behaviors for COVID-19 infection. To improve personal preventive behaviors in healthcare workers, these factors should be emphasized.
Development of a prognostic model of COVID-19 severity: a population-based cohort study in Iceland
Authors: Eythorsson Elias , Bjarnadottir Valgerdur , Runolfsdottir Hrafnhildur Linnet , Helgason Dadi , Ingvarsson Ragnar Freyr , Bjornsson Helgi K. , Olafsdottir Lovisa Bjork , Bjarnadottir Solveig , Agustsson Arnar Snaer , Oskarsdottir Kristin , Thorvaldsson Hrafn Hliddal , Kristjansdottir Gudrun , Bjornsson Aron Hjalti , Emilsdottir Arna R. , Armannsdottir Brynja , Gudlaugsson Olafur , Hansdottir Sif , Gottfredsson Magnus , Bjarnason Agnar , Sigurdsson Martin I. , Indridason Olafur S. , Palsson Runolfur 
Published: September 2022

Abstract
Background
The severity of SARS-CoV-2 infection varies from asymptomatic state to severe respiratory failure and the clinical course is difficult to predict. The aim of the study was to develop a prognostic model to predict the severity of COVID-19 in unvaccinated adults at the time of diagnosis.

Methods
All SARS-CoV-2-positive adults in Iceland were prospectively enrolled into a telehealth service at diagnosis. A multivariable proportional-odds logistic regression model was derived from information obtained during the enrollment interview of those diagnosed between February 27 and December 31, 2020 who met the inclusion criteria. Outcomes were defined on an ordinal scale: (1) no need for escalation of care during follow-up; (2) need for urgent care visit; (3) hospitalization; and (4) admission to intensive care unit (ICU) or death. Missing data were multiply imputed using chained equations and the model was internally validated using bootstrapping techniques. Decision curve analysis was performed.

Results
The prognostic model was derived from 4756 SARS-CoV-2-positive persons. In total, 375 (7.9%) only required urgent care visits, 188 (4.0%) were hospitalized and 50 (1.1%) were either admitted to ICU or died due to complications of COVID-19. The model included age, sex, body mass index (BMI), current smoking, underlying conditions, and symptoms and clinical severity score at enrollment. On internal validation, the optimism-corrected Nagelkerke’s R2 was 23.4% (95%CI, 22.7–24.2), the C-statistic was 0.793 (95%CI, 0.789-0.797) and the calibration slope was 0.97 (95%CI, 0.96–0.98). Outcome-specific indices were for urgent care visit or worse (calibration intercept -0.04 [95%CI, -0.06 to -0.02], Emax 0.014 [95%CI, 0.008–0.020]), hospitalization or worse (calibration intercept -0.06 [95%CI, -0.12 to -0.03], Emax 0.018 [95%CI, 0.010–0.027]), and ICU admission or death (calibration intercept -0.10 [95%CI, -0.15 to -0.04] and Emax 0.027 [95%CI, 0.013–0.041]).

Conclusion
Our prognostic model can accurately predict the later need for urgent outpatient evaluation, hospitalization, and ICU admission and death among unvaccinated SARS-CoV-2-positive adults in the general population at the time of diagnosis, using information obtained by telephone interview.
Patients at a high risk of PJI: Can we reduce the incidence of infection using dual antibiotic-loaded bone cement?
Authors: Berberich Christof , Josse Jerôme , Ruiz Pablo Sanz 
Published: September 2022

AbstractProsthetic joint infection (PJI) is one of the most devastating complications of orthopedic surgery. However, not all patients are equally at the risk of severe infection. The incidences of PJI vary with the host and surgery-related risk factors. It is now generally accepted that some important medical comorbidities may predispose the patients to a high risk of PJI. Time-consuming and invasive surgical procedures, such as revision arthroplasties, are also associated with a high incidence of PJI, presumably due to the increased risk of surgical site contamination. Effective infection-preventing strategies should begin with identifying and optimizing the patients at a high risk of infection prior to surgery. Optimizing the operating room environment and antibiotic prophylaxis are also essential strategies that help minimize the overall incidence of infection in orthopedic surgery. The ideal antibiotic prophylaxis is still under debate, and discussions have emerged about whether variations or adjustments to the standard protocol are justified in patients at a high risk of infection. This also includes evaluating the possible benefits and risks of using high-dose dual antibiotic-loaded bone cement instead of low-dose single antibiotic-loaded bone cement in arthroplasty. This review summarizes the evidence showing that the combination of two local antibiotics in bone cement exerts a strong and longer-lasting antimicrobial effect against PJI-associated pathogens. This conclusion is consistent with the preliminary clinical studies showing a low incidence of PJI in high-risk patients undergoing cemented hemiarthroplasty, cemented revision, and primary arthroplasty if dual ALBC is used. These results may encourage clinicians to consolidate this hypothesis in a wider clinical range.
Systematic review: exercise training for equinus deformity in children with cerebral palsy
Authors: Zahran Dina Abd Elwahab , Bahr Walaa Mahfouz , Abd Elazim Faten Hassan 
Published: September 2022

Abstract
Background
Children with spastic cerebral palsy have motor deficits that can lead to joint contractures. Ankle equinus deformity is the most common foot deformity among children with CP. It is caused by spasticity and muscular imbalance in the gastrocnemius-soleus complex. Exercise enhances ankle function, improves gait in children with CP, and prevents permanent impairment. Therefore, there is a need to investigate the effectiveness of different types of exercise used in equine management. The aim of this review is to assess the evidence of the effectiveness of exercise training on equinus deformity in children with cerebral palsy.

Methodology
The American Academy for Cerebral Palsy and Developmental Medicine and Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology were used to conduct this systematic review. Four databases (PubMed, Cochrane Library, Physiotherapy Evidence Database (PEDro), and Google Scholar) were searched till January 2022 using predefined terms by two independent reviewers. Randomized controlled trials published in English were included. This review included seven studies with 203 participants ranging in age from 5 to 18 years. Methodological quality was assessed using AACPDM, PEDro scale; also, levels of evidence adopted from modified Sacket’s scale were used for each study. Primary outcomes were dorsiflexion angle, plantar flexion angle, and plantar flexors strength.

Results
The quality of studies ranged from good (six studies) to fair (one study). The level of evidence was level 1 (six studies) and level 2 (one study) on modified Sacket’s scale. There is a low risk of bias in the included studies. Meta-analysis revealed a non-significant difference in plantar flexor strength, plantar flexion angle, and dorsiflexion angle between the study and control group.

Conclusions
There is a need for high-quality studies to draw a clear conclusion as the current level of evidence supporting the effectiveness of various types of exercises on equinus deformity in children with cerebral palsy is still weak.
3D inversion of vertical gravity gradient with multiple graphics processing units based on matrix compression
Authors: Hou Zhenlong , Wei Jikang , Mao Tianxiao , Zheng Yujun , Ding Yuchen 
Published: September 2022

Among single-component inversions, vertical gravity gradient data have been proven to be sufficient to obtain reasonable density distribution. However, the increasing numbers of observations and model parameters inevitably produce a large-scale sensitivity matrix, causing problems such as large memory occupation and slow computations in the inversion. Aiming at solving these long-standing problems, we have introduced a matrix compression technique to reduce memory occupation and constructed a hybrid parallel algorithm for accelerating focusing inversion. We develop the source codes and the design pattern for the proposed algorithm using C language with open multiprocessing and compute unified device architecture for further improving algorithm feasibility and reusability. A graphical user interface and visualization tools also are developed using Python. In the tests with synthetic data produced by numerical simulation and real data from Vinton Dome, it is verified that the inversion can produce an accurate result of density values and object location. The performance analysis is conducted using different scales of data. The speedup increases with the increasing number of graphics processing units (GPUs) and model parameters, proving that the proposed parallel algorithm is scalable. We compare this algorithm with others without matrix compression to demonstrate how the compressed sensitivity matrix storing and accessing method influences inversion performance. More specifically, for an inversion with 100 × 100 × 20 cells, the average speed is approximately 6 s per iteration, with a maximum speedup of 36.94. Our algorithm has a short running time and high multiple-GPU parallel efficiency. Hence, the hybrid parallel algorithm is more powerful at implementing large-scale data calculations and could be used for solving computing problems in mass data inversions.
Diminished Advantage or Persistent Protection? A New Approach to Assess Immigrants' Mortality Advantages Over Time
Authors: Zheng Hui , Yu Wei-hsin 
Published: September 2022

Abstract
Much research has debated whether immigrants' health advantages over natives decline with their duration at destination. Most such research has relied on (pooled) cross-sectional data and used years since immigration as a proxy for the duration of residence, leading to the challenge of distilling the duration effect from the confounding cohort-of-arrival and age-of-arrival effects. Because longitudinal studies tend to use self-rated health as the outcome, the changes they observed may reflect shifts in immigrants' awareness of health problems. We illuminate the debate by examining how immigrants' mortality risk—a relatively unambiguous measure tied to poor health—changes over time compared to natives' mortality risk. Our analysis uses the National Health Interview Survey (1992–2009) with linked mortality data through 2011 (n = 875,306). We find a survival advantage for U.S. immigrants over the native-born that persisted or amplified during the 20-year period. Moreover, this advantage persisted for all immigrants, regardless of their race/ethnicity and gender or when they began their U.S. residence. This study provides unequivocal evidence that immigrant status' health protection as reflected in mortality is stable and long-lasting.
Skin Tone and the Health Returns to Higher Status
Authors: DeAngelis Reed T. , Hargrove Taylor W. , Hummer Robert A. 
Published: September 2022

AbstractThis study addresses two questions. First, why do Black Americans exhibit worse health outcomes than White Americans even at higher levels of socioeconomic status (SES)? Second, are diminished health returns to higher status concentrated among Black Americans with darker skin color? Novel hypotheses are tested with biosocial panel data from Add Health, a nationally representative cohort of Black and White adolescents who have transitioned to adulthood. We find that White and light-skin Black respondents report improved health after achieving higher SES, on average, while their darker-skin Black peers report declining health. These patterns persist regardless of controls for adolescent health status and unmeasured between-person heterogeneity. Moreover, increased inflammation tied to unfair treatment and perceptions of lower status helps to account for patterns of diminished health returns for dark-skin Black groups. Our study is the first to document skin tone heterogeneity in diminished health returns and one of few studies to identify life course stress processes underlying such disparities. We consider additional processes that could be examined in future studies, as well as the broader health and policy implications of our findings.
The Impact of Frailty on Traumatic Brain Injury Outcomes: An Analysis of 691 821 Nationwide Cases
Authors: Tang Oliver Y. , Shao Belinda , Kimata Anna R. , Sastry Rahul A. , Wu Joshua , Asaad Wael F. 
Published: September 2022

BACKGROUND:
Frailty, a decline in physiological reserve, prognosticates poorer outcomes for several neurosurgical conditions. However, the impact of frailty on traumatic brain injury outcomes is not well characterized.

OBJECTIVE:
To analyze the association between frailty and traumatic intracranial hemorrhage (tICH) outcomes in a nationwide cohort.

METHODS:
We identified all adult admissions for tICH in the National Trauma Data Bank from 2007 to 2017. Frailty was quantified using the validated modified 5-item Frailty Index (mFI-5) metric (range = 0-5), with mFI-5 ≥2 denoting frailty. Analyzed outcomes included in-hospital mortality, favorable discharge disposition, complications, ventilator days, and intensive care unit (ICU) and total length of stay (LOS). Multivariable regression assessed the association between mFI-5 and outcomes, adjusting for patient demographics, hospital characteristics, injury severity, and neurosurgical intervention.

RESULTS:
A total of 691 821 tICH admissions were analyzed. The average age was 57.6 years. 18.0% of patients were frail (mFI-5 ≥ 2). Between 2007 and 2017, the prevalence of frailty grew from 7.9% to 21.7%. Frailty was associated with increased odds of mortality (odds ratio [OR] = 1.36, P < .001) and decreased odds of favorable discharge disposition (OR = 0.72, P < .001). Frail patients exhibited an elevated rate of complications (OR = 1.06, P < .001), including unplanned return to the ICU (OR = 1.55, P < .001) and operating room (OR = 1.17, P = .003). Finally, frail patients experienced increased ventilator days (+12%, P < .001), ICU LOS (+11%, P < .001), and total LOS (+13%, P < .001). All associations with death and disposition remained significant after stratification for age, trauma severity, and neurosurgical intervention.

CONCLUSION:
For patients with tICH, frailty predicted higher mortality and morbidity, independent of age or injury severity.
Expansion of Photocatalytic C(sp3)-H Functionalization to Allylation, Alkynylation, and Imination
Authors: Shih Yi-Lun , Huang Sheng-Hao , Wu Yen-Ku , Ryu Ilhyong 
Published: September 2022

Abstract
Photocatalytic C(sp3)-H allylation, alkynylation, and imination using unsaturated benzenesulfonyl compounds were studied using decatungstate anion, W10O324−, as photocatalyst. In all these reactions, site-selective C(sp3)-H bond cleavage was successfully combined with the radical addition/β-scission sequence.