bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aspect term extraction and optimized deep fuzzy clustering-based inverted indexing for document retrieval
Authors: CHANDWANI GUNJAN , Ahlawat Anil , Dubey Gaurav 
Published: June 2022

Abstract
Finding good relevant documents for query optimization is a well-known difficulty in the field of document retrieval. This paper develops a novel approach, named Exponential Aquila Optimizer (EAO)-based Deep Fuzzy Clustering for retrieving the documents. The proposed technique effectively finds the relevant documents and tries to understand the relationship among the documents and queries in terms of the significance of documents for query optimization. Here, the Deep Fuzzy Clustering is employed for performing cluster-based inverted indexing where the Training procedure of Deep Fuzzy Clustering is done using the developed optimization algorithm, named EAO. Meanwhile, the developed EAO is newly designed by the incorporation of EWMA and AO. In addition, complex query matching is done using the Tversky index for the user-based queries, such as multigram queries and semantic queries. On the other hand, the RV coefficient is accomplished for performing query optimization for relevant document retrieval. The proposed technique achieves better performance in terms of the performance metrics, like precision, recall, and F-measure with the maximum precision of 1, maximum recall of 0.956, and maximum F-measure of 0.977, respectively.
Inner and outer setting factors that influence the implementation of the National Diabetes Prevention Program (National DPP) using the Consolidated Framework for Implementation Research (CFIR): A Qualitative Study
Authors: Madrigal Lillian , Manders Olivia C. , Kegler Michelle , Haardörfer Regine , Piper Sarah , Blais Linelle M. , Weber Mary Beth , Escoffery Cam 
Published: June 2022

Abstract
Background: Scaling evidence-based interventions is key to impacting population health. The National DPP lifestyle change program is one such intervention that has been scaled across the United States over the past 20 years, however enrollment is an ongoing challenge. Furthermore, little is known about which organizations are most successful with program delivery, enrollment, and scaling. This study aims to understand more about the internal and external organization factors that impact program implementation and reach.Methods: Between August 2020 and January 2021, data were collected through semi-structured key informant interviews with 30 National DPP delivery organization implementers. This study uses a qualitative cross-case construct rating methodology to assess which Consolidated Framework for Implementation Research (CFIR) Inner and Outer Setting constructs contributed (both in valence and magnitude) to the organization’s current level of implementation reach (measured by average participant enrollment per year). A construct by case matrix was created with ratings for each CFIR construct by interviewee and grouped by implementation reach level.Results: Across the 16 inner and outer setting constructs and subconstructs, the interviewees in the higher reach group provided stronger (+2) and more positive examples related to implementation and enrollment of the program, while the lower reach groups reported stronger (-2) and more negative examples across rated constructs. Four inner setting constructs/subconstructs (structural characteristics, compatibility, goals & feedback, and leadership engagement) were identified as “distinguishing” based on the difference between groups by average rating (+.5 difference between levels), the examination of the number of extreme (+2 or -2) ratings within levels, and the thematic analysis of the content discussed.No outer setting constructs were distinguishing. Four constructs/subconstructs (incentives & rewards, learning climate, access to knowledge & information, and patient needs & resources) were not discussed in relation to implementation reach sufficiently for the rating analysis. Conclusions: Our study identified a number of influential CFIR constructs and their impact on National DPP implementation reach. These findings can be leveraged to improve efforts in recruiting and assisting delivery organizations to increase the reach and scale of the National DPP as well as other evidence-based interventions.
Efficient targeted mutagenesis by endogenous promoter controlled tRNA-gRNA array of CRISPR/Cas9 in potato and application in Solanum etuberosum
Authors: Jing Shenglin , Xiong Wenwen , Liu Huimin , Dong Fei , Chen Kaiyuan , Du Juan , Song Botao 
Published: June 2022

Abstract
Here, we developed an endogenous promoter controlled polycistronic tRNA-gRNA (PTG) array of CRISPR/Cas9 in potato for efficient multiplex mutagenesis. The editing efficiency was significantly improved in potato combined with short-term heat treatment. In addition, our use of CRISPR/Cas9 to engineer mutations in wild solanum species demonstrates a high editing efficiency of the developed PTG/Cas9 in Solanum etuberosum, which contributes to develop Solanum etuberosum as a new model for functional genetics research in solanum.
EvaLuation of early CRRT and beta-blocker InTervention in patients with ECMO (ELITE) trial: Study protocol for a 2 × 2 partial factorial randomized controlled trial
Authors: Dong Jianzeng , Wang Xiaofang , Wang Hong , Du Xin , Wang Zhiyan , Li Chenglong , Anderson Craig , Zhang Jinying , Hou Xiaotong 
Published: June 2022

Abstract
Background
In critically ill patients requiring extracorporeal membrane oxygenation (ECMO) therapy, early initiation of continuous renal replacement therapy (CRRT) and beta-blockade of catecholamine-induced inotropic effects may improve outcomes.
Methods
A 2×2 partial factorial randomized controlled trial in eligible ECMO patients without a clear indication or contraindication to either interventions are centrally randomly assigned to (A) early or conventional-indicated CRRT, and/or (B) beta-blocker or usual care. The primary outcome is all-cause mortality at 30 days for both arms. A total of 496 participants provides 80% power to determine a 20% risk reduction in mortality at 30 days with 5% type I error.
Discussion
This trial will help define the role of early CRRT and beta-blockade in ECMO patients.
Trial registration:
ClinicalTrials.gov Identifier: NCT03549923, Registered on 8 June 2018. World Health Organization International Clinical Trials Registry Platform (WHO ICTEP) network: https://trialsearch.who.int/Trial2.aspx?TrialID=NCT03549923). The Ethics Committee of Beijing Anzhen Hospital Approval ID is 2018013.
Inhibiting Property of Phytoconstituents of ‘Aconitum Heterophyllum’ Against Omicron Variant of SARS-CoV-2: Molecular Docking, Molecular Dynamic and MM-GBSA approach
Authors: Lakhera Shradha , Devlal Kamal , Rana Meenakshi , Ghosh Arabinda 
Published: June 2022

Abstract
Omicron’s traces have been found significantly faster than the Delta variant. Persons who already have been vaccinated are also affected by this variant. This shows that vaccines taken to combat COVID-19 are less effective in preventing the Omicron’s transmission. Thus, the identification of effective candidates to fight against Omicron has been the top priority in pharmaceutics. The present study deals with the investigation of the antiviral activities of the phytocompounds of Aconitum heterophyllum against the Omicron variant. The systematic in-silico study done in the paper reveals the good binding of Isoatisine with spike glycoprotein of Omicron. Isoatisine molecule follows most of the pharmacokinetic properties that make it a better drug-like molecule. The computed global reactivity parameters fairly justified the high reactivity of the Isoatisine molecule. This study aims to discover the novel antiviral activity of Isoatisine to counter the Omicron protein. The results of this study can also be considered for experimental validation and clinical trials.
Context Analysis for the Implementation of Physical Activity on Prescription at Madrid Primary Health-care
Authors: Calonge-Pascual Sergio , Gómez Miguel-Ángel , Belmonte-Cortés Susana , Mallén José Antonio Casajús , González-Gross Marcela 
Published: June 2022

Abstract
There is a clear disconnect between the physical activity (PA) health-related benefits and Physical Activity on Prescription (PAP) role in Primary Health-care (PHC) settings. This study aims to assess the self-perception of nurses and general practitioners (GPs) toward PAP in Madrid PHC settings. From a list of 3,850 GPs and 3,547 nurses, a total of 319 GPs and 285 nurses responded to a validated choice-modeling questionnaire. A classification tree analysis (CHAID) was used to analyze which variable or combination of variables, better predicts PAP self-perceptions barriers and facilitators of PHC staff.Almost 100% of PHC professionals are aware of the PA health-related benefits, although, 24.3% to 37.0% of them, considered it adequate only for some sex-specific and aged patients. Only 14.7% of GPs knew WHO PA guidelines in contrast to 75.7% of nurses. Under a classification tree analysis, for the collaboration with all health professionals in the exercise prescription, there were significant differences (p<0.001) between PHC staff agreeing with PA promotion collaboration with all health professionals (yes:29.50%; no:70.50%), and in a second level there were significant differences (p<0.001), with low collaboration with all PAP community resources.PHC professionals are conscious of PA health benefits despite the lack of training and willingness to collaborate with all PAP staff and community resources available under a multidisciplinary PAP approach.This study was enrolled in the Central Commission for research of the Region of Madrid, with the protocol code: 42/17; ID:RP1811600040 (date: 13/12/2017). This research was performed in accordance with the Declaration of Helsinki.
Cardiovascular disease, self-care and emotional regulation processes in adult patients Balancing unmet needs and Quality of Life
Authors: Giacomo Dina Di , Ranieri Jessica , Guerra Federica , Cilli Eleonora , Ferri Claudio 
Published: June 2022

Abstract
Background. Cardiovascular disease is a chronic non-communicable illness that causes more than half of all deaths across Europe. Unhealthy lifestyle, inadequate adherence to medical prescriptions, themselves associated with psycho-emotional disorders are considered risk factors for reduced quality of life as well physical condition.Objective. Aim of our study was to understand predictive factors for management by evaluating psychological aspects, self-care processes and emotional regilati0on in CVD outpatients.Methods. An observational study was conducted. 61 patients, age 18–75 years (M 56.4 ± sd 12.0), diagnosed with CVD participated in the study. The psychological battery was administered during clinical follow-up oriented to detect emotional and psychological dimensions as well adaptive behavioral and quality of life.Results. Finding showed that emotional dysregulation might influence QoL, particularly significant effect of awareness (β = 0.022; SE = 1.826; p < 0.002), goals (β = - 0.54; SE = 1.48; p < 0.001) and clarity (β = - 0.211; SE = 2.087; p < 0.003). The results also suggest that the mediated effect accounted for awareness index was 18.7% (R2 = 0.187) of the variance; goals index 62.8% (R2 = 0.628) of the variance and, then significant mediated effect of clarity was 58.8% (R2 = 0.588) of the variance. This evidence suggests that the relationship between triggers and QoL is mediated by emotional dysregulation indexes. Conclusion. Poor adherence to CVD pharmacological therapy could be addressed by identifying the emotional characteristics, subjective emotion ability, and self-care process of patients who are or may be at risk of non-persistence.
Incidence, Risk Factors, Prevention and Treatment of Postmastectomy Pain Syndrome in Breast Cancer: a Multicenter Study
Authors: Kong Xiangyi , Yang Qinheng , Ouyang Liquan , Liu Qiang , Dong Hao , Wang Zhongzhao , Fang Yi , Wang Jing , Ren Yinpeng 
Published: June 2022

Abstract
Postmastectomy pain syndrome (PMPS) is a common postoperative condition after breast cancer surgery, The aim of this study was to investigate the incidence rate and risk factors of PMPS, and to propose prevention and treatment methods. The study included 1790 postoperative breast cancer patients from three hospitals from 2017 to 2021, of which 302 (13.0%) patients with PMPS were included in the study. Age, breast surgery type, axillary surgery type and radiotherapy are the risk factors of PMPS. Age, radiotherapy and chemotherapy affect the pain degree of PMPS during movement. For breast cancer patients with high risk factors, pain should be actively prevented during perioperative period. Oral pharmacological agents, multidisciplinary combination therapy, local anesthetics and regional anesthesia are the most common treatment of PMPS.
High-pressure behavior of synthetic quenchable hydroxylbastnasite-(Sm): Implications for rare earth elements, carbon, and water transmission into the deep earth
Authors: Li Lin , Liang Wen , Yang Ziqiang , Wen Jingyuan , Zhang Qiqi , Santosh M. , Li Sheng-Rong 
Published: June 2022

Abstract
Carbonatites are one of the major archives of rare earth elements (REE), and their formation in some cases is linked to the deep subduction and melting of REE-rich oceanic sediments. With a view to investigate this model through high pressure experiments, we synthesized hexagonal hydroxyl rare earth carbonate, hydroxylbastnasite-(Sm) Sm(CO3)OH, using DS 6×600t cubic-anvil-apparatus under the pressure and temperature conditions of 3 GPa and 1073.15K. The accurate crystal structure of Sm(CO3)OH was determined using single crystal X-ray diffraction (XRD), which shows the crystal to be hexagonal with cell parameters a = b = 12.2143(7)Å, c = 9.8393(6)Å, V = 1271.26(17)Å3, and space group P6̅. The high-pressure properties of synthesized Sm(CO3)OH were investigated using in-situ synchrotron powder XRD and Raman spectroscopy at pressures up to 20.97 GPa at ambient temperature. The compressibility of the crystal axes was determined as 𝛽𝑎=𝛽𝑏= -2.21×10-3GPa-1, 𝛽𝑐= -1.79×10-3GPa-1 in the pressure range of this study. The isothermal pressure-volume data at room temperature are described using the third-order Birch-Murnaghan equation of state with 𝐾0=137(4) GPa, 𝐾′=4 ,𝑉0=1264.8(3) Å 3. The axial compressional behavior of the hexagonal Sm(CO3)OH was also fitted with a linearized third-order Birch–Murnaghan equation of state, showing an obvious anisotropy with 𝐾𝑎0=128(3) GPa , 𝑎0=12.189(8) Å and 𝐾𝑐0=164(6) GPa , 𝑎0=9.828(7) Å. In-situ synchrotron radiation XRD and Raman spectra of the synthesized quenchable crystal of Sm(CO3)OH displays no phase transition at pressure of a rangefrom ambient to 20.97 GPa and room temperature, indicating that hydroxylbastnasite-(Sm) may play a potential role as conveyor for the migration of rare earth elements (REE), carbon (C) and water (H) to the deep earth during plate subduction.
A Computational Study of Potential Therapeutics for COVID-19 Invoking Conceptual Density Functional Theory
Authors: . Saloni , Kumari Dimple , Ranjan Prabhat , Chakraborty Tanmoy 
Published: June 2022

Abstract
With the amount of destruction COVID-19 has caused to the human race and collapsed health systems, it is impossible to reverse the effect. In spite, the future can be saved with a potential therapeutic medicine that could be effective in the treatment. In this article, we have investigated some of the repurposed drugs namely Camostat mesylate, Hydroxychloroquine, Nitazoxanide, and Oseltamivir in terms of Conceptual Density Functional Theory (CDFT) based descriptors, IR spectra, and thermochemical properties. It is found that the drug camostat mesylate with minimum optimization energy has a maximum HOMO-LUMO gap whereas hydroxychloroquine with maximum optimization energy offers a minimum HOMO-LUMO gap. Results obtained from CDFT-based descriptors indicate that hydroxychloroquine is the most reactive drug among them. Thermochemical data reveals that camostat mesylate has the maximum heat capacity, entropy, and thermal energy. Based on our study, it is possible to propose that the camostat mesylate and hydroxychloroquine have the potential for further exploration as potential therapeutic drugs for COVID-19.
An Automated Segmentation of Leukocytes Using Modified Watershed Algorithm on Peripheral Blood Smear Images
Authors: Abrol Vipasha , Dhalla Sabrina , Gupta Savita , Singh Sukhwinder , Mittal Ajay 
Published: June 2022

Abstract
Purpose: Leukemia can be detected by an abnormal rise in the number of immature lymphocytes and by a decrease in the number of other blood cells. To diagnose the existence of leukemia, image processing techniques are utilized to examine microscopic peripheral blood smear (PBS) images automatically and swiftly.Methods: To the best of our knowledge, the initial step in subsequent processing is a robust segmentation technique for identifying leukocytes from their surroundings. The paper presents the segmentation of leukocytes in which three color spaces are considered in this study for image enhancement. The proposed algorithm uses marker-based watershed algorithm and peak local maxima.Results: The algorithm was used on three different datasets with various color tones, image resolutions, and magnifications. The average precision for all three-color spaces was same i.e. 94% but Structural Similarity Index Metric (SSIM) and recall of HSV was better than other two.Conclusion: The results of this study will aid experts in narrowing down their options for segmenting leukemia. Based on the comparison, it was concluded that when the colour space correction technique is used, the accuracy of the proposed methodology improves.
Process evaluation of a kindergarten-based, family involved intervention to prevent obesity in early childhood: The Toybox Study Malaysia
Authors: Cheah Whye Lian , Poh Bee Koon , Talib Ruzita Abd. , Julia Ai Cheng Lee , Denise Choon Lian Koh , Reeves Sue , Essau Cecilia , Summerbell Carolyn , Yatiman Noor Hatizah , Anchang Gordon Nicholas Jemat , Gibson Leigh Edward 
Published: June 2022

Abstract
Background: Toybox is a kindergarten-based intervention programme targeting physical activity, sedentary behaviour, snacking and drinking in improving healthy energy balance-related behaviour among children attending kindergartens in Malaysia. It was based on a quasi-experimental design involving 780 children from 22 intervention kindergartens and 26 control kindergartens. This paper aims to report the process evaluation of this intervention. Methods: We assessed five process indicators: recruitment, retention, dosage, fidelity, and satisfaction in the intervention kindergartens. Data collection included teachers’ monthly logbook, and post-intervention feedback through questionnaire and focus group discussion with teachers, parents, and children. Results: A total of 1072 children were invited and 837 children completed the programme. Retention with the programme was 88.4% (with 110 children dropping out). 91% of the 44 teachers and their assistants engaged positively with one or more of the process evaluation data collection methods. In terms of dosage and fidelity, 76% of parents had received newsletters, tip cards and posters at the appropriate times. All teachers and their assistants reported being satisfied with the intervention programme, but also that there were some barriers to implementation including suitable environments (one example, insufficient space indoors to carry out activities to reduce sedentary behaviour), and that some of the kangaroo stories were not of sufficient interest to the children or too long to hold their attention. Parents reported that the materials were easy to understand and had improved their knowledge. More than 88% of parents were satisfied with the family-based activities, and had enjoyed them. The children were reported to show a change in positive behaviour in drinking water and consumption of fruits and vegetables.Conclusions: The Toybox programme was feasible to implement and acceptable, although several factors were usefully identified which could easily be improved before this intervention is scaled up and embedded into normal practice across Malaysia.
Improvement of Clustering Classification Performance Using Row-Based Filtering for health care application
Authors: Patra Radhanath 
Published: June 2022

Abstract
A combination of unsupervised and supervised machine learning with an outlier-based row filtering technique is proposed in this paper. Our idea is based upon the concept of row-based filtering technique, a novel approach of records selection for a given structured dataset. Initially, dropping the class label, dataset is divided into groups by using clustering algorithm and class labels are assigned to the clusters. The cluster labels are compared with the original class labels. Records having matching class label and cluster label are extracted to frame a dataset having matching record. Remaining records after filtering matching records are treated as outliers. UCI repository datasets such as Breast cancer, Pima Indian diabetes dataset, Hungarian dataset, Indian liver patient dataset and Cleveland heart dataset are used to analyze the performance of proposed method. For clustering K means clustering algorithm is used and the classification performance is measured by applying various classification algorithm such as K Nearest Neighbour, J48, Naïve Bayes and Logistic regression.
COVID-19 and food handling practice: The case of food businesses in Jigjiga, Eastern Ethiopia
Authors: Farah Alinoor Mohamed , Nour Tahir Yousuf , Roble Abdurahman Kedir , Obsiye Muse , Aden Mowlid Akil , Hussein Muktar Arab , Budul Abdullahi Bedel , Omer Muktar , Abdi Abdulahi Siraj , Mohamed Hashim Sheik , Hashi Mohamed Hussein , Getnet Fentabil 
Published: June 2022

Abstract
Objective
The aim of this study is to investigate the food safety knowledge and practices of food handlers in the context of covid-19.
Result
A total of 384 food handlers were approached and all of them responded (response rate = 100%). Majority of the participants were under 40 years of age (n = 369, 96.1%). Of the total participants, 50.8% were male with a mean age of 32.1 (SD: 4.8). Majority of the participants were under 40 years of age (n = 369, 96.1%). Female, younger adults, married, educated and those with prior food safety training had better food handling practice than their counter parts.
Preparation and thermal properties of novel N-arylpiperazine phosphoramidate flame-retardant copolymer
Authors: Song Jianan , Wang Jiaqi , Zhang Xi , Meng Jiajia , Li Songjun 
Published: June 2022

Abstract
In order to improve the flame retardancy of polystyrene (PS), developing reactive-type flame retardants is a promising approach. In this work, a novel N-arylpiperazine phosphoramidate monomer, 2-((phenoxy(4-phenylpiperazin-1-yl)phosphoryl)oxy)ethyl methacrylate (PPPEM), was facilely synthesized and used as a reactive-type flame retardant. The obtained monomer was then copolymerized with styrene through the free radical bulk polymerization. The thermal stability of copolymers was measured by the thermogravimetric analysis. The addition of the PPPEM units increased decomposition temperature of the copolymers, indicating the improvement of the thermal stability. The glass transition temperature of the copolymers remained little changed with varied amount of the PPPEM, implying that the introduction of PPPEM units did not evidently affect the mobility of the PS main chain. In addition, PPPEM unites can contribute to the decrease of the peak heat release rate and improvement of the flame retardancy. The novel N-arylpiperazine phosphoramidate monomer show a great potential for application in reactive-type flame retardants.