bluuebunny/crossref_metadata_2025_split huggingface dataset:
Red Light Phototherapy Using Light-Emitting Diodes Inhibits Melanoma Proliferation and Alters Tumor Microenvironments
Authors: Austin Evan , Huang Alisen , Wang Jennifer Y. , Cohen Marc , Heilman Edward , Maverakis Emanual , Michl Josef , Jagdeo Jared 
Published: June 2022

BackgroundTotal annual cancer rates have decreased due to improved treatment and prevention. However, the incidence of melanoma is rising, and not all patients respond to immune and targeted approaches. Therefore, we sought to determine the efficacy of red light (RL) phototherapy in preclinical models of melanoma.MethodsMelanoma cells (A375, B16F10, MNT-1) were irradiated with RL. Melanoma proliferation, apoptosis, oxidative stress, and p53 phosphorylation were measured in vitro. In C57BL/6 mice, phototherapy safety, B16F10 tumor growth, and immunocyte infiltration were assessed following RL.ResultsIn vitro, 640 J/cm2 RL decreased cellular proliferation without increasing apoptosis, while 1280 J/cm2 increased apoptosis. RL increased intracellular reactive oxygen species generation and p53 phosphorylation. In animal models, 2560 J/cm2 RL significantly prevented melanoma growth and increased the expression of CD103+ dendritic cells. 1280 and 1920 J/cm2 RL decreased tumor volume, but not significantly. RL did not cause skin inflammation or erythema in normal skin.ConclusionRL represents a potentially safe and effective melanoma therapeutic. RL prevented tumor growth and increased the expression of immune markers, such as CD103, that are associated with favorable melanoma outcomes. Further research is needed to determine the optimal clinical treatment regimen for melanoma using RL.
Higher Body Fat in Children and Adolescents With Type 1 Diabetes–A Systematic Review and Meta-Analysis
Authors: Zheng Yuwen , Rostami Haji Abadi Mahdi , Gough Jonathan , Johnston James J. D. , Nour Munier , Kontulainen Saija 
Published: June 2022

AimsHigher prevalence of overweight and obesity in children and adolescents with type 1 diabetes (T1D) suggests alterations are required in body composition. However, differences in body composition between children with T1D and typically developing children (TDC) have not been synthesized using meta-analysis. Therefore, we conducted a systematic review and meta-analysis to compare body composition between children with T1D and TDC, and to explore the role of disease and non-disease related factors in potential body composition differences.MethodsStudies were performed comparing dual-energy x-ray absorptiometry-acquired total body fat and lean mass, absolute (kg) and relative (%) values, between children with T1D and TDC. We reported mean differences with 95% confidence intervals (CI) from meta-analysis and relative between-group %-differences. We used meta-regression to explore the role of sex, age, height, body mass, body mass index, Hemoglobin A1c, age of onset, disease duration, and insulin dosage in the potential body composition differences between children with T1D and TDC, and subgroup analysis to explore the role of geographic regions (p &lt; 0.05).ResultsWe included 24 studies (1,017 children with T1D, 1,045 TDC) in the meta-analysis. Children with T1D had 1.2 kg more fat mass (kg) (95%CI 0.3 to 2.1; %-difference = 9.3%), 2.3% higher body fat % (0.3–4.4; 9.0%), but not in lean mass outcomes. Age of onset (β = −2.3, −3.5 to −1.0) and insulin dosage (18.0, 3.5–32.6) were negatively and positively associated with body fat % mean difference, respectively. Subgroup analysis suggested differences among geographic regions in body fat % (p &lt; 0.05), with greater differences in body fat % from Europe and the Middle East.ConclusionThis meta-analysis indicated 9% higher body fat in children with T1D. Earlier diabetes onset and higher daily insulin dosage were associated with body fat % difference between children with T1D and TDC. Children with T1D from Europe and the Middle East may be more likely to have higher body fat %. More attention in diabetes research and care toward body composition in children with T1D is needed to prevent the early development of higher body fat, and to minimize the cardiovascular disease risk and skeletal deficits associated with higher body fat.
Laser-Induced Forward Transfer of Silver Nanoparticles for a Black Metal Absorber
Authors: Li Ruo-Zhou , Guo Lvjiu , Liu Leilei , Yang Mingqing , Fang Yuming , Yu Ying , Yan Jing 
Published: June 2022

Plasmonic nanostructures emerged as an appealing approach for black metal absorbers (BMAs) to provide significant light absorption. We present the simple and rapid fabrication of BMAs using laser-induced forward transfer of silver nanoparticles (AgNPs). Randomly distributed plasmon silver nanostructures at a multiscale were produced simultaneously during laser transfer, providing significant light absorption and antireflection features. The laser-transferred BMAs exhibit excellent absorption capacity of a value over 96% and a minimum reflection of 0.38%. A high scanning speed of 10 m/s was used that can complete the laser-induced forward transfer (LIFT) process within 2 s for a 1 cm2 area. The nearfield light confinement is discussed in terms of the morphology of the obtained nanostructures. Photothermal conversion with macroscale temperature rising was demonstrated for the LIFT process is an effective method for the industrial production of BMAs with excellent absorption capacity.
Resistance Exercise in People With Stage-3 Chronic Kidney Disease: Effects of Training Frequency (Weekly Volume) on Measures of Muscle Wasting and Function
Authors: Geneen Louise J. , Kinsella Jodie , Zanotto Tobia , Naish Patrick F. , Mercer Thomas H. 
Published: June 2022

Background: Resistance training (RT) is a proven anabolic intervention in people living with and without chronic kidney disease (CKD). To date, there is a dearth of knowledge regarding the dose-response relationship of RT in the non-dialysis dependent CKD population. Therefore, we aimed to explore the effects of RT frequency (weekly volume) on established measures of muscle wasting and function in CKD.Methods: Twenty people with stage-3 CKD (CKD-3) were allocated to either a low frequency (one-session per week, RT1) or higher frequency (three-sessions per week, RT3) 12-week RT programme consisting of lower extremity strengthening exercises. The two RT programmes were not volume matched. Assessment outcomes before and after the intervention included measures of total and regional body composition, muscle size and architecture, strength, physical function, and uraemic symptoms.Results: Significant improvements over time in muscle size and architecture, strength, physical function, and uraemic symptoms were observed for both RT1 and RT3. Compared to RT1, participants who performed RT3 showed greater increases in vastus lateralis (VL) anatomical cross-sectional area (30.8% vs. 13.2%, p &lt; 0.001) and pennation angle (36.3% vs. 17.5%, p = 0.008) after 12 weeks. In either group, there were no significant changes over time in mid-VL fascicle length, nor in measures of total body composition and upper arm muscle strength.Conclusion: Despite the group differences observed in the VL physiological adaptations, the strength and physical function responses, as well as the reductions of uraemic symptoms, were similar whether training once or thrice weekly. Therefore, performing RT just once per week may be an effective pre-habilitation strategy for people with CKD-3.
Effects of Acute Hypoxic Stress on Physiological and Hepatic Metabolic Responses of Triploid Rainbow Trout (Oncorhynchus mykiss)
Authors: Han Buying , Meng Yuqiong , Tian Haining , Li Changzhong , Li Yaopeng , Gongbao Caidan , Fan Wenyan , Ma Rui 
Published: June 2022

This experiment simulated the hypoxic environment caused by actual production operations in fish farming (i.e., catching, gathering, transferring, and weighting) to study the effects of acute hypoxic conditions on the physiological and metabolic responses of triploid rainbow trout (O. mykiss). Two groups of fish weighting 590 g were sampled in the normoxia group (dissolved oxygen above 7 mg/L) and hypoxia group (dissolved oxygen ranged from 2 to 5 mg/L for 10 min). The results showed that 1) regarding stress response, hypoxia increased plasma levels of cortisol, heat shock protein 70 (HSP-70), lysozyme, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatine phosphokinase (CPK); induced the expression of hepatic genes encoding nuclear factor erythroid 2 related factor 2 (Nrf2), interferon γ (IFN-γ) and interleukin-1β (IL-1β). 2) Regarding metabolism response, hypoxia increased plasma levels of globulin (GLOB), glucose (GLU), triglyceride (TG) and lactate dehydrogenase (LDH); upregulated the hepatic gene expression of phosphoenolpyruvate carboxykinase, (PEPCK), pyruvate dehydrogenase kinase (PDK1), acetyl-CoA carboxylase (ACC) and acetyl-CoA oxidase (ACO); downregulated the hepatic gene expression of carnitine palmitoyl transferase 1 (CPT1); and unchanged the expression of hepatic genes in glycolysis and autophagy. 3) In response to hypoxia-inducible factors (HIFs), the hepatic HIF-2α gene was activated in the hypoxia group, but HIF-1α gene expression remained unchanged. Thus, during acute hypoxic stress, triploid rainbow trout were in a defensive state, with an enhanced immune response and altered antioxidant status. Additionally, the hepatic mitochondrial oxidation of glucose- and lipid-derived carbon in trout was suppressed, and hepatic gluconeogenesis and lipid synthesis were activated, which might be regulated by the HIF-2α pathway.
COVID-19-Related Psychosocial Care in General Hospitals: Results of an Online Survey of Psychosomatic, Psychiatric, and Psychological Consultation and Liaison Services in Germany, Austria, and Switzerland
Authors: Schaefert Rainer , Stein Barbara , Meinlschmidt Gunther , Roemmel Noa , Huber Christian G. , Hepp Urs , Saillant Stéphane , Fazekas Christian , Vitinius Frank 
Published: June 2022

BackgroundThe coronavirus disease 2019 (COVID-19) pandemic was accompanied by new challenges for psychosocial health care to enable the support of affected patients, their families, and staff in general hospitals. In this study, we aimed to describe the structures and procedures put in place by psychosomatic, psychiatric, and psychological consultation and liaison (CL) services in German, Austrian, and Swiss general hospitals, and to elucidate the emerging needs for cooperation, networking, and improvement.MethodsWe conducted a cross-sectional online survey between December 2020 and May 2021, using a 25-item questionnaire derived from relevant literature, professional experience, and consultation with the participating professional societies. The survey was disseminated via national professional societies, relevant working and interest groups, and heads of the above-mentioned CL services.ResultsWe included responses from 98 CL services in the analyses, with a total response rate of 55% of surveyed hospital CL services; 52 responses originated from Germany, 20 from Austria, and 26 from Switzerland. A total of 77 (79%) of the 98 responding CL services reported that “COVID-19-related psychosocial care” (COVID-psyCare) was provided in their hospital. Among these, 47 CL services (61%) indicated that specific cooperation structures for COVID-psyCare had been established within the hospital. A total of 26 CL services (34%) reported providing specific COVID-psyCare for patients, 19 (25%) for relatives, and 46 (60%) for staff, with 61, 12, and 27% of time resources invested for these target groups, respectively. Regarding emerging needs, 37 (48%) CL services expressed wishes for mutual exchange and support regarding COVID-psyCare, and 39 (51%) suggested future changes or improvements that they considered essential.ConclusionMore than three-quarters of the participating CL services provided COVID-psyCare for patients, their relatives, or staff. The high prevalence of COVID-psyCare services targeting hospital staff emphasizes the liaison function of CL services and indicates the increased psychosocial strain on health care personnel during the COVID-19 pandemic. Future development of COVID-psyCare warrants intensified intra- and interinstitutional exchange and support.Trial RegistrationClinicalTrials.gov NCT04753242, version 11 February 2021.
The Association Between 2, 4-Dichlorophenoxyacetic Acid and Erectile Dysfunction
Authors: Wang Wei , Ma Yucheng , Chen Jiawei , Peng Liao , Gao Xiaoshuai , Lin Lede , Zhang Fuxun , Xiong Yang , Qin Feng , Yuan Jiuhong 
Published: June 2022

Background2, 4-dichlorophenoxyacetic acid (2,4-D) is one of the most frequently used herbicides in the world, and it has been linked with low testosterone; however, studies regarding its effect on erectile function are limited. The current study aimed to determine the association between the 2,4-D exposure and erectile dysfunction (ED) in men from the National Health and Nutrition Examination Survey (NHANES).MethodsWe analyzed data for urinary 2,4-D levels from 1,311 men (&gt;20 years of age) in the NHANES 2001–2004. ED was assessed by a single, validated survey question. Multivariable logistic regression analysis utilizing sampling weights was performed to determine the relationship between 2,4-D exposure and ED.ResultsMultivariable logistic regression models demonstrated no statistically significant association between 2,4-D exposure and ED after full adjustment [odds ratio (OR) 1.02; 95% CI 0.77–1.36; P = 0.882)]. Men in the 2,4-D quartile 4 groups were not associated with an increased risk of ED (OR 1.13; 95% CI 0.74–1.75; P for trend = 0.481). Furthermore, the association between urinary 2,4-D level and ED was not significant in the subgroup analysis stratified by age, BMI, cardiovascular disease, hypertension, diabetes, and high cholesterol.ConclusionWe demonstrated that there was no association between 2,4-D exposure and ED. Further studies are warranted to corroborate our results.
Spatial Variability of In Situ Above-Water Reflectance in Coastal Dynamic Waters: Implications for Satellite Match-Up Analysis
Authors: Nasiha Hussain J. , Wang Ziwei , Giannini Fernanda , Costa Maycira 
Published: June 2022

The validation of ocean color satellite retrievals generally relies on analyzing match-ups between in situ measurements and satellite retrievals. These analyses focus on the quality of the satellite data, however, of the same importance is the quality of the in situ data. Here, we present the spatial variability of in situ above-water reflectance (Rrs(0+)) within the spatial resolution of different ocean color satellites—300, 900, 1500, and 3000 m spatial resolutions, mimicking Sentinel 3 OLCI and MODIS-Aqua satellites, and possible 3 × 3 and 5 × 5 windows. Radiometric data was acquired with autonomous radiometric sensors installed in the British Columbia Ferry Services Inc. vessel “Queen of Alberni” from May to September 2019, crossing the optically dynamic waters of the Strait of Georgia, Canada. The dataset followed optimal geometry of acquisition and processing, including corrections for skylight radiance signals, ship superstructure, the non-isotropic distribution of the water-leaving radiances, and quality control. A total of 33,073 spectra at full resolution, corresponding to 10 days, were considered for the analysis presented here. The results showed that, overall, the subpixel variability increased as the spatial resolution of the sensor or the window size increased, mainly in a linear fashion. Specifically, spatial variability of Rrs(0+) was the largest (∼18% and 68% for 900 and 3000 m pixel resolution, respectively) in Near Field Plume Interface waters, followed by in the Ocean Water Interface (∼28% and 35%, respectively), thus indicating spatial heterogeneity of interface waters. Further, we found that the estuarine waters showed higher subpixel Rrs(0+) variability (∼8% and 16% for 900 and 3000 m, respectively) compared with plume and oceanic waters. We showed that the high spatial variability in Rrs(0+) was primarily associated with the spatial dynamics of the optical water constituents, thus limiting the use of these datasets as Fiducial Reference Measurements and for validation of satellite-derived atmospherically corrected reflectance. We suggest that spatial variability of the in situ Rrs(0+) should also be considered in the selection criteria for good match-up data, especially for data acquired in coastal dynamic systems. As a result, it will advocate for the exclusion of interface or transition water pixel grids in order to avoid compromising the statistical result of satellite validation.
Evoking Losing and Finding Community in Drama: A Methodology-in-Motion for Pandemic Times
Authors: Gallagher Kathleen , Cardwell Nancy , Tripathi Munia Debleena 
Published: June 2022

Our article explores the impact of the global health pandemic on our five-year, multi-sited, collaborative ethnographic study titled Global Youth (Digital) Citizen-Artists and their Publics: Performing for Socio-Ecological Justice (2019-2024). We illustrate how our arts-led, youth-driven ethnographic ”methodology-in-motion” responded to a destabilized world by planning, listening, and seeing differently across local and global research contexts through virtual fieldwork. By focusing on reciprocity and the relational, we examine how researchers, youth participants, and global collaborators, managed to ”lose” and ”find” each other through creative, artistic encounters.
Carto-Elicitation: Improvised Performances/Narratives of Identity, Memory, and Sites of Fascination
Authors: Sefton Terry G. , Ricketts Kathryn 
Published: June 2022

This paper describes the pedagogical roots of the work we do, both as teachers and as performers; and how our work reaches beyond the classroom and into community, eliciting narratives and weaving them through improvised dance and music collaborations, eventually onto the walls of an art museum. Our concept was to solicit stories that told of some event that happened in a particular place, and that left a memory that was tethered to that place. We collected stories, pooled our own stories, “pinned” stories to their geographic locations, and then transformed these stories through improvised movement and sound.
Economic and Mathematical Model of a Gas Supply System Based on Biomethane
Authors: Суслов Д. Ю. 
Published: June 2022

Постановка задачи. Перспективным направлением развития систем газоснабжения является использование альтернативного источника энергии - биометана. Использование биометана в централизованных системах газоснабжения требует разработки научно обоснованных методов их расчета и проектирования. Результаты. Разработана экономико-математическая модель системы газоснабжения на основе биометана, учитывающая затраты на биометановую установку, транспортировку субстрата, газопроводы биометана и станцию подачи. Получены выражения для определения удельных капитальных затрат на строительство и эксплуатационных расходов на биогазовые установки, станции очистки биогаза и подачи биометана в системы газоснабжения. Выводы. Установлено, что применение биометановых установок на территории Вейделевского района Белгородской области позволяет получить 5 474 481 м/год биометана с содержанием метана 98 %, что составляет 18,7 % от общего газопотребления района. При этом оптимальная длина газопровода для подачи биометана составляет 9 208 м, а оптимальный радиус действия биометановой установки - 20 781 м.
Statement of the problem. A promising direction in the development of gas supply systems is the use of an alternative energy source - biomethane. The use of biomethane in centralized gas supply systems requires the development of scientifically based methods for their calculation and design. Results. An economic and mathematical model of a gas supply system based on biomethane has been developed, taking into account the costs of a biomethane plant, substrate transportation, biomethane gas pipelines and a feed station. Expressions are obtained for determining the specific capital costs for construction and operating costs for biogas plants, biogas purification plants and biomethane supply to gas supply systems. Conclusions. It has been established that the use of biomethane plants on the territory of the Veidelevsky district of the Belgorod region makes it possible to obtain 5,474,481 m / year of biomethane with a methane content of 98%, which is 18.7% of the total gas consumption of the district. At the same time, the optimal length of the gas pipeline for supplying biomethane is 9 208 m, and the optimal range of the biomethane plant is 20 781 m.
Analisis Perbandingan Model Altman, Springate, Zmijewski, Dan Grover Dalam Memprediksi Kebangkrutan Perusahaan Di Bursa Efek Indonesia (Studi Empiris Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia Periode 2012-2017)
Authors: Robiansyah Anton , Yusmaniarti Yusmaniarti , Sari Iwi Karmita , Novrianda Herry , Irwanto Tito 
Published: June 2022

This study compares the feasibility of the Bankruptcy prediction model if used to predict manufacturing companies. The test in this study is logistic regression. The sample in this study consisted of 79 manufacturing companies listed on the Indonesia Stock Exchange from 2012-2017 with a purposive sampling method. This research is quantitative research where the analytical tool used is logistic regression test with SPSS version 18.
The study results indicate that of the four models studied. The Springate model cannot predict the bankruptcy of manufacturing companies listed on the Indonesia Stock Exchange because it has a significant value of 0.175 > 0.05. This study also indicates that the Altman model is the most appropriate for predicting the bankruptcy of manufacturing companies compared to Springate, Zmijewski, and Grover.
PENGARUH KINERJA KEUANGAN TERHADAP NILAI PERUSAHAAN DENGAN CORPORATE SOCIAL RESPONSIBILITY SEBAGAI VARIABEL MODERATING (Studi Empiris Pada Perusahaan Perbankan Yang Terdaftar di Bursa Efek Indonesia Periode 2018-2020)
Authors: Zs Nensi Yuniarti , Nurangraini Isma , Astuti Budi , Ranidiah Furqonti , Pertiwi Dinal Eka 
Published: June 2022

This study aims to determine whether financial performance as measured by Non Performing Loans (NPL), Loan To Deposit Ratio (LDR), Capital Adequacy Ratio (CAR) has an effect on firm value and whether Corporate Social Responsibility (CSR) moderates the relationship between financial performance. to the value of the company. The study was conducted on banking companies listed on the Indonesian Stock Exchange in 2018-2020.
This study uses the purposive sampling method, with the number of companies 12 x 3 years of research and a total sample of 36. The statistical method used is SPSS multiple linear regression, and Moderated Regression Analysis (MRA) with hypothesis testing, partial t statistical test, and coefficient of determination test.
The results of this study state that: NPL has a positive and insignificant effect on firm value, with a significance of 0.128. LDR has a negative and significant effect on firm value, with a significance of 0.027. CAR has a positive and significant effect on firm value, with a significance of 0.007. with an adjusted r square value of 25.5%. Corporate Social Responsibility (CSR) cannot moderate the relationship between financial performance as measured by NPL and firm value. Corporate Social Responsibility (CSR) cannot moderate the relationship between financial performance as measured by LDR and firm value. Corporate Social Responsibility (CSR) cannot moderate the relationship between financial performance as measured by CAR and firm value.