bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE FIGHT AGAINST MONEY LAUNDERING AND TERRORISM FINANCING: THE PORTUGUESE EXPERIENCE
Authors: Conceição Ana Raquel , Piton André Paulino 
Published: March 2022

Contextualização do tema:When it comes to investigating terrorism and, consequently, money laundering, the consideration of balancing the defence of rights and liberties becomes less stringent in the eyes of States. They tend to automatically replace community or the collective interest. It is, therefore, important to question if the weighting and balancing result from the legal text. Objetivos: One of the legal instruments is Act 83/2017, of August 18th, and we will review its regime by introducing its main measures and assessing the (dis)respect for fundamental rights. Metodologia: For the development of the research, the inductive method was used from the literature review.Resultados: The number of entities and duties leads us to conclude that States, without any doubt, cannot fight these crimes on their own. They must unite, apply measures that can produce effects in every country, but even when doing so, they need their citizens to help them in this fight; such citizens are those that deal with financing activities, those who deal with criminals themselves or even those with relation to people that have political or economic power.
LA REDUCTIO AD UNITATEM DEL DANNO NON PATRIMONIALE IN ITALIA: UNA MISSION IMPOSSIBLE…?
Authors: Viglianisi Ferraro Angelo 
Published: March 2022

Contextualização do tema: l’11 novembre 2008, quattro storiche sentenze della Corte di Cassazione italiana (a Sezioni Unite) hanno fissato una nuova e singolare lettura dell’art. 2059 c.c. (sul “danno non patrimoniale”), stabilendo principi che tutti i giudici italiani avrebbero dovuto applicare. Invero, a distanza di quasi 15 anni da quelle importanti pronunce, continuano ad esserci molte incertezze in materia.Objetivos: l’articolo analizza i recenti sviluppi di un istituto tra i più complessi in Italia: quello del danno non patrimoniale. Metodologia: il lavoro si avvale di una metodologia che coniuga l’analisi del dato normativo a quella della casistica giurisprudenziale, senza omettere di considerare il contributo della dottrina più accreditata sull’argomento. Resultados: la conclusione a cui si perviene è che l’obiettivo di garantire l’eliminazione di divergenze eccessive nell’interpretazione ed applicazione della figura giuridica in questione non è ancora stato affatto raggiunto.
Pedagogía de la alimentación tradicional
Authors: Camargo Coronel Diana Paola 
Published: March 2022

El presente artículo es el resultado de la investigación del proyecto de aula en la Institución Educativa Técnica Plinio Mendoza Neira del municipio de Toca Boyacá. Aquí se muestra cómo fue el proceso investigativo con los estudiantes acerca de los alimentos ancestrales: papa, ruba, nabo, ibia, calabaza y frijol, al utilizar la metodología de la Investigación acción participativa con los sabedores locales para describir los alimentos consumidos y cultivados desde épocas prehispánicas. El texto habla de la importancia de relacionar la academia, los conocimientos tradicionales y los alimentos como parte del proceso motivacional de los estudiantes, en el marco del desarrollo de una agricultura comercial.
Una propuesta curricular para fortalecer competencias científicas desde la gestión académica
Authors: Pedraza Jurado Yeison Mauricio , Álvarez Santoyo Juan Hildebrando 
Published: March 2022

El presente artículo describe los aspectos relevantes que permitieron diseñar una propuesta curricular para el fortalecimiento de la competencia científica en estudiantes de básica secundaria del Colegio San Francisco de Asís, el Playón, Santander. Una propuesta que incluye una fundamentación pedagógica, evaluativa y didáctica derivada del análisis de algunos componentes de la gestión académica, tales como currículo, práctica de aula, plan de mejoramiento y uso pedagógico de evaluaciones externas.
La investigación se realizó con un enfoque cualitativo, siguiendo las fases de la investigación acción. Un estudio aplicado a una población participante de 27 estudiantes de noveno grado y 8 docentes de la Sede A del Colegio San Francisco de Asís. Se empleó dos técnicas de investigación: El análisis documental y la entrevista semiestructurada, lo cual permitió diseñar instrumentos de investigación como la rúbrica de valoración de textos y la guía de entrevista semiestructurada. Instrumentos que describieron y exploraron detalles del currículo de ciencias naturales, pruebas Saber, los planes de mejoramiento y prácticas de aula.
La información recopilada se analizó y sistematizó mediante el programa Atlas ti 8.4 para construir las categorías y subcategorías, códigos y mapas de redes. Los resultados se evaluaron mediante el uso de una rúbrica de análisis multimétodo y la lectura hermenéutica del investigador. Estos resultados indican que a partir de componentes de la gestión académica es factible caracterizar una propuesta curricular pertinente para la competencia científica amparada en fundamentos teóricos del currículo, la evaluación procesal y formativa, la didáctica conectivista de Siemens y la pedagogía constructivista.
Sarapan, Asupan Zat Gizi Makro Dan Cairan, Persepsi Kenyamanan Suhu Ruang Terhadap Persepsi Kinerja Pekerja
Authors: Wulandari Selly Apliyanti , Jus’at Idrus , Mulyani Erry Yudhya , Sa’pang Mertien , Wahyuni Yulia 
Published: March 2022

Sebuah perusahaan tentu ingin memiliki sumber daya manusia yang berkualitas sehingga dapat menghasilkan kinerja yang baik, tetapi terkadang banyak perusahaan yang tidak memperhatikan kesehatan pekerjanya terutama tentang gizi pekerjanya, karena gizi merupakan salah satu aspek penting dalam meningkatkan kinerja dan produktivitas. Tujuan: Untuk mengetahui hubungan sarapan, asupan zat gizi makro, asupan cairan, dan persepsi kenyamanan suhu ruang kerja terhadap persepsi kinerja pekerja di PT. Intan Pertiwi Industri. Metode: Penelitian ini menggunakan desain Cross Sectional yang merupakan variabel independen maupun variabel dependen diamati dan diukur pada saat yang bersamaan. Jumlah sampel 59 responden. Pengambilan data menggunakan angket dan food record 2x24 jam. Analisis bivariat yang digunakan menggunalan uji korelasi pearson. Hasil: Terdapat hubungan yang signifikan antara energi sarapan, asupan protein, asupan lemak, dan persepsi kenyamanan suhu ruang kerja dengan persepsi kinerja P-value kurang dari atau sama dengan 0,05. Terdapat hubungan hampir signifikan (borderline) antara asupan karbohidrat, asupan cairan dengan persepsi kinerja P-value kurang dari atau sama dengan 0,1. Kesimpulan: Ada hubungan antara energi sarapan, asupan protein, asupan lemak, persepsi kenyamanan suhu ruang kerja dengan persepsi kinerja. Ada hubungan tetapi kurang signifikan antara asupan karbohidrat, asupan cairan dengan persepsi kinerja.
Mental illness vs mental retardation
Authors: Ahmad Mir Javaid , Mushtaq Bushra , Mushtaq Onaisa Aalia 
Published: March 2022

Mental illness and mental retardation are completely two different terms and with two different concepts in them and cannot be used interchangeably. Mental illness can be caused by number of causes like genetic causes, environmental causes and chemical imbalances in the brain. While mental retardation in the imbalance in normal development of the brain in an individual by which it can be categorized into mild Estimates of the prevalence of comorbidity of psychiatric disorders and mental retardation in community and clinical populations range from 14.3 to 67.3 percent. Mental illness can be described when behaviour of individuals is inappropriate, irrational, or unrealistic in most physical, or in mental illness the person’s behaviour is not normal. Mental disorder can be caused by physical, psychological or environmental factors, or a com- bination of all three. While mental illness is not level of intelligence, it is possible for a person to be both mentally ill and retarded.
Serotonin 5-HT7 Receptor is A Biomarker Poor Prognostic Factor and Induces Proliferation of Triple Negative Breast Cancer Cells Through FOXM1
Authors: Cınar Venhar , Hamurcu Zuhal , Guler Ahsen , Nurdinov Nursultan , Ozpolat Bulent , Çınar Venhar 
Published: March 2022

Abstract
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer and associated with poor prognosis and shorter survival due to significant genetic heterogeneity, drug resistance and lack of effective targeted therapeutics. Therefore, novel molecular targets and therapeutic strategies are needed to improve patient survival. Serotonin (5-hydroxytriptamine, 5-HT) has been shown to induce growth stimulatory effects in breast cancer. However, the molecular mechanisms by which 5-HT exerts its oncogenic effects in TNBC still are not well understood. In the present study, we demonstrated that 5-HT induces cell proliferation of TNBC cells and expression of 5-HT7 receptor and FOXM1 oncogenic transcription factor. We found that expression of 5-HT7 receptor is up-regulated in TNBC cells and higher 5-HT7 expression is associated with poor patient prognosis and shorter patient survival. Genetic and pharmacological inhibition of 5-HT7 by siRNA and metergoline, respectively, suppressed TNBC cell proliferation and FOXM1 and its downstream mediators, including eEF2-Kinase (eEF2K) and cyclin-D1. Overall, our findings suggest for the first time that the 5-HT7 receptor promotes FOXM1, eEF2K and cyclin D1 signaling to support TNBC cell proliferation, thus inhibition of 5-HT7/FOXM1 signaling may be used as a potential therapeutic strategy for targeting TNBC.
Application of Risk Scoring System in Intra-operative Cell Salvage Patients: A Retrospective Study Based on Multicenter Data
Authors: LYU BIN , Liu Xinghui , Chen Daijuan , Chen Meng , Gou Jinhai 
Published: March 2022

Abstract
Background: Intraoperative cell salvage (IOCS) is widely used in cesarean section, and this study applied use of multi-center big data of IOCS in cesarean section to establish a bleeding risk assessment scale for IOCS patients. The purpose of this retrospective study was to explore the safety, health economy, and application guidelines of IOCS in obstetrics. Methods: We included 2621 patients who received IOCS technology during cesarean section in 12 hospitals between January 2012 - January 2020. The patients were divided into two groups, Group A, intraoperative blood loss <1500 ml; Group B, intraoperative blood loss ≥1500 ml. The clinical and imaging data associated with the risk of bleeding in patients taking IOCS were collected, and multivariable logistic regression analysis was conducted to develop a scoring system. Results: All patients who received IOCS in our study had no serious adverse outcomes. For the 2621 patients who take IOCS technology, while 407 cases not perform the blood transfusion, resulting in a waste rate of 15.5% for the resource. Multivariate logistic regression analysis was performed by selecting significant indicators from the univariate analysis and high-risk factors related to bleeding. The variables were maternal age ≥35 years, number of cesarean sections, placental attachment position, and placenta previa, each scored 1 point; placenta accreta, blood pool in the placenta, abnormal retroplacental myometrium, placenta protruding to the anterior uterine wall and continuous disruption of the myometrium, each scored 2 points; and cervical canal invasion, scored 4 points. All were risk factors for intraoperative blood loss volume ≥1500 ml in IOCS patients. A bleeding risk scoring system was constructed according to the above indicators. The area under the curve of the receiver operating characteristic curve (AUC) of the scoring system was 0.837, and a total score of 5 points was identified as the optimal cut-off value, allowing good differentiation of intraoperative massive bleeding in IOCS patients (AUC, 0.837; 95% confidence interval, 0.820–0.854), along with a sensitivity of 81.2% and specificity of 75.3%.Conclusion: IOCS technology is a safe and effective measure to solve the problem of clinical blood source shortages in obstetric cesarean section. Moreover, the bleeding risk scoring system could better guide the clinical application of IOCS technology. Therefore, strictly mastering the clinical application guidelines of IOCS can save medical resources and reduce the economic burden on patients.
AYA ‘Can-Sleep’ Program : protocol for a stepped-care, cognitive behavioral therapy based approach to the management of sleep difficulties in adolescents and young adults with cancer
Authors: Vaughan Emma Marie , Ftanou Maria , Lewin Jeremy , Murnane Andrew , Berger Ilana , Wiley Josh F , Hickey Martha , Bullen Dani , Jefford Michael , Goldin Jeremy , Stonehouse Jeremy , Thompson Kate 
Published: March 2022

Abstract
Background
Sleep problems are reported in up to 50% of adolescents and young adults (AYA) with cancer. Cognitive Behaviour Therapy for insomnia (CBTi) is considered the gold-standard treatment. In the AYA population, CBTi is associated with improvements in insomnia, daytime sleepiness, fatigue and quality of life. In adults, stepped care interventions can improve accessibility to CBTi. This study aims to evaluate the acceptability and feasibility of a stepped care CBTi program in AYA with cancer.
Methods and analysis
: AYA (target N=80) will be screened using the Insomnia Severity Index (ISI) and Epworth Sleepiness Scale (ESS). When sleep difficulties are identified by the ISI and/or ESS, they will be screened for obstructive sleep apnoea and restless leg syndrome and referred as indicated. The remainder will be offered a stepped care sleep program including CBT self-management and coaching (first step). Participants will then be re-screened at 5 weeks, and those with ongoing sleep difficulties will be offered individualised CBT (second step). Recruitment and retention rates, adherence to intervention, and time taken to deliver screening and intervention will be collected to assess the feasibility of the program. AYA and clinicians will complete evaluation surveys to assess the acceptability of the AYA Can-Sleep Program.
Discussion
We seek to contribute to the evidence-base regarding screening and treatment of sleep difficulties in the AYA population by implementing the AYA Can-Sleep program and determining its feasibility and acceptability as an approach to care in an Adolescent & Young Adult Cancer Service.
A Transition of Care Model from Hospital to Community for Hispanic/Latino Adult Patients with Diabetes: Design and Rationale for a Pilot Study
Authors: Corsino Leonor , Padilla Blanca Iris 
Published: March 2022

Abstract
Background: The Hispanic/ Latino population are disproportionately affected and have a higher risk of developing diabetes than their non-Hispanic White counterparts and worse diabetes-related outcomes. Diabetes continues to be an economic burden. This economic burden is partially due to the significantly higher rates of hospital readmission for individuals with diabetes. People with diabetes, particularly those who are members of racial/ethnic minority groups are at higher risk for readmission and emergency department (ED) visits. Despite recommendations regarding transition of care, an optimal approach to the transition of care for ethnic/minority patients remains unclear. Methods: The study population includes self- Identified Hispanic/Latino adults with diabetes. We have two aims: 1) designed and developed a transition of care model and 2) pilot test the newly developed transition of care model. For aim 1, semi-structures interviews conducted with patients and providers. For aim 2, patients admitted to the hospital enrolled to receive the newly designed transition of care model. For aim 1, patients and providers completed a short questionnaire. For aim 2, patients completed a set of questionnaires including demographic information, medical history, sociocultural and social support. The primary outcomes for aim 2 are readmission and emergency department visit within 30 days post discharge. Feasibility outcomes include number of participants identified, number of patients enrolled, number of participants who completed all the questionnaires, number of participants with a 30-day follow up call, and number of participants who completed the 30-day post-discharge questionnaire. Due to the COVID-19 pandemic the study design was adapted to include the Plan-Do-Study-Act framework to adjust to the ongoing changes in transition of care due to the pandemic burden on the health care systems. Conclusion: Transition of care for Hispanic/Latino patients with diabetes remains a major area of interest that requires further research. The pandemic required that we adapted the study to reflect the realities of health care systems during a time of crisis. The methods share in this manuscript can potentially help other investigators as they designed their studies. Trial registration: ClinicalTrials.gov identifier NCT04864639. 4/29/2021. https://clinicaltrials.gov/ct2/show/NCT04864639
Organ At Risk (OAR) Data on Clinical Toxicity in The Treatment of Bulky Adrenal Metastases With Stereotactic Ablative Radiotherapy (SABR)
Authors: Berber Tanju , Gürsel Özge Kandemir , Yıldırım Berna Akkuş , Erken Aysun Arslantaş , Dinçer Selvi Tabak , Gürdal Necla 
Published: March 2022

Abstract
Aim
Effectiveness of the treatment was investigated in terms of treatment responses and side effects with OAR in oligometastatic patients whose adrenal metastases were treated with SABR.
Methods
Patients who underwent radiosurgery for adrenal gland metastasis in our clinic were evaluated retrospectively for the patient, tumor, treatment characteristics, survival outcomes, and dosimetric parameters with toxicity.
Results
Of the 22 patients in our study. The primary tumor site was the lung in 20 (90.9%) of 22 patients, while ten (45.5%) of the patients had isolated adrenal metastasis. The median dose was 30 Gy (R:18–50) with a median fraction of five (R:3–10). The median PTV volume was 55 cc. (IQR:44-120cc). From the first diagnosis to adrenal gland radiotherapy, the median time was 6.9 months. The median follow-up was 7 months (R:2–48), and the median survival was 9.5 months (R:2–48). The local control rate was 72.7% in the 6th month, 63.6% in the 1st year, and 59.0% in the 2nd year, and overall survival was 72.7%, 50%, and 31.8%, respectively. The median overall survival was 9.5 months for all patients (p = 0.049) and 6.5 months in the presence of diffuse disease. Deaths of patients due to distant progression were also found to be significant (p = 0.03). Patients with isolated adrenal metastasis survived for 14.4 months after the treatment; while extra-adrenal metastasis lived for a median of 6.6 months (P = 0.01).
Conclusion
SABR in patients with oligometastatic adrenal disease not only provides symptom control but may also provide prolonged survival with minimal toxicity.
Identification of Candida Sp. In the Oral Cavity of the Sumatran Elephant (Elephas Maximus Sumatranus)
Authors: Erina Erina , Velayati Abdul Jabbar , Sayuti Arman , Dewi Maryulia , AK M Daud 
Published: March 2022

Abstract
Sumatran elephants are categorized as large mammals with critically endangered conservation status established by the International Union for Conservation of Nature and Natural Resources (IUCN). This research was conducted to identify Candida sp. in the oral cavity of the Sumatran elephant. The study was conducted based on the Odds and Bernaerts method. Swab sample of the elephant's oral cavity was observed after it was planted on CAC media and incubated for 48 hours at 37°C. The identification was carried out based on macroscopic observations of the differences in color of the Candida sp. Observation results showed that in the oral cavity of sumatran elephants can be overgrown with Candida albicans (100%), Candida tropicalis (100%), Candida parapsilosis (25%), Candida glabrata (25%) and other Candida (50%). It can be concluded that 4 types of Candida can be identified in oral cavity of sumatran elephant.
Persistent Colonisation of Antimicrobial Silver-Impregnated Shower Heads and Hoses Presents A Risk for Acquisition of Pseudomonas Aeruginosa in Healthcare Settings
Authors: Yetiş Özge , Ali Shanom , Karia Kush , Bassett Paul , Wilson Peter 
Published: March 2022

Abstract
Pseudomonas aeruginosa in healthcare waters presents an infection-risk to immune-suppressed patients. We introduced interventions (quarterly antimicrobial silver-impregnated shower head-hose replacement and shower-hose truncation) to determine effect on presence/persistence of P. aeruginosa in hospital shower-waters and drains over a seven-month survey (560 samples; 14 time-points) on augmented-care (immune-compromised) and non-augmented (general) wards. P. aeruginosa occurrence in the shower or drain predisposed to colonisation of the adjacent site/outlet (chi-square; p<0.001). Up to 80% of shower-waters/drains (augmented-care) were heavily-contaminated (>300CFU) before intervention and persisted despite remediation (P>0.05). Conversely, for every week elapsed, P. aeruginosa in the non-augmented wards increased by ~18% (P<0.001) in shower waters (OR=1.19; CI=1.09-1.31) and drains (OR=1.18; CI=1.09-1.30).Imipenem (showers), and aztreonam/ciprofloxacin-resistance (drains) occurred in up to 75% of sites in augmented-care with cefepime-resistance expressed in the general wards. Resistance-phenotypes declined after remediation despite ciprofloxacin being the only antimicrobial agent prescribed during this period.The shower environment in non-augmented care settings represents unrecognised reservoirs of P. aeruginosa. Once P. aeruginosa-bioburden is established, antimicrobial shower/hose materials and shortening of hoses are ineffective options for remediation. Efficacy-validation of antimicrobial materials and prevention of cross-contamination of the shower environment, plumbing and control-valves is essential to minimise acquisition of P. aeruginosa by vulnerable patients.