bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Adhesive Hyaluronic Acid/Antimicrobial Peptide Composite Hydrogel with Antioxidant Capability and Photothermal Activity for Infected Wound Healing
Authors: Xiong Jingyi , Yang Zhuo‐Ran , Lv Niannian , Du Kehan , Suo Huinan , Du Shuo , Tao Juan , Jiang Hao , Zhu Jintao 
Published: April 2022

AbstractBacterial infection can delay wound healing, causing wounds to deteriorate and even threaten the patient's life. Recently, although many composite hydrogels as wound dressing have been developed, it is still highly desired to construct photothermal hydrogels with antimicrobial and antioxidant properties to accelerate the infected wound healing. In this work, a hyaluronic acid (HA)‐based composite hydrogel consisting of a dopamine‐substituted antimicrobial peptide (DAP) and Iron (III) ions is developed, which exhibits photothermal‐assisted promotion and acceleration of healing process of bacteria‐infected wounds. DAP, serving as both antimicrobial agent and ROS‐scavenger, forms Schiff's base bonds with aldehyde hyaluronic acid (AHA) and iron‐catechol coordination bonds to reinforce the composite hydrogel. The presence of Fe3+ can also promote covalent polymerization of dopamine, which endows the hydrogel with photothermal capacity. The in vitro and in vivo experiments prove that the composite hydrogel can effectively accelerate the infected wound healing process, including antibacterial, accelerated collagen deposition, and re‐epithelization. This study suggests that the multifunctional composite hydrogel possesses remarkable potential for bacteria‐infected wound healing by combining inherent antimicrobial activity, antioxidant capability, and photothermal effect.
SIRT1 inhibition‐induced senescence as a strategy to prevent prostate cancer progression
Authors: Huang Shih‐Bo , Rivas Paul , Yang Xiaoyu , Lai Zhao , Chen Yidong , Schadler Keri L. , Hu Ming , Reddick Robert L. , Ghosh Rita , Kumar Addanki P. 
Published: April 2022

AbstractEmerging evidence suggests an important role for SIRT1, a nicotinamide adenine dinucleotide (NAD)‐dependent deacetylase in cancer development, progression and therapeutic resistance; making it a viable therapeutic target. Here, we examined the impact of resveratrol‐mediated pharmacological activation of SIRT1 on the progression of HGPIN lesions (using the Pten−/− mouse model) and on prostate tumor development (using an orthotopic model of prostate cancer cells stably silenced for SIRT1). We show that precise SIRT1 modulation could benefit both cancer prevention and treatment. Positive effect of SIRT1 activation can prevent Pten deletion‐driven development of HGPIN lesions in mice if resveratrol is administered early (pre‐cancer stage) with little to no benefit after the establishment of HGPIN lesions or tumor cell implantation. Mechanistically, our results show that under androgen deprivation conditions, SIRT1 inhibition induces senescence as evidenced by decreased gene signature associated with negative regulators of senescence and increased senescence‐associated β‐galactosidase activity. Furthermore, pharmacological inhibition of SIRT1 potentiated growth inhibitory effects of clinical androgen receptor blockade agents and radiation. Taken together, our findings provide an explanation for the discrepancy regarding the role of SIRT1 in prostate tumorigenesis. Our results reveal that the bifurcated roles for SIRT1 may occur in stage and context‐dependent fashion by functioning in an antitumor role in prevention of early‐stage prostate lesion development while promoting tumor development and disease progression post‐lesion development. Clinically, these data highlight the importance of precise SIRT1 modulation to provide benefits for cancer prevention and treatment including sensitization to conventional therapeutic approaches.
Feeding the modern sow to sustain high productivity
Authors: Theil Peter K. , Krogh Uffe , Bruun Thomas S. , Feyera Takele 
Published: April 2022

AbstractSelection for hyper‐prolific sows has increased the litter size by more than 50% during the last three decades, and proper nutrition of the female pigs has concomitantly changed due to improved prolificacy and productivity of gilts and sows. This review summarizes the physiological characteristics and nutritional challenges associated with feeding modern hyper‐prolific sows during the gilt rearing period and during gestation, transition, and lactation periods. The review presents up‐to‐date knowledge of the energy and lysine requirements of female pigs and focuses on how nutrition may increase fat gain and limit protein and weight gain in the gilt rearing period and in early and mid‐gestation. In late gestation, fetal and mammary growth should be considered and during the transition, colostrum yield and farrowing performance need to be optimized. Finally, milk production should be optimized and body mobilization should be minimized in the lactation period to achieve high feed efficiency in hyper‐prolific sows.
Rat Brain Global Ischemia–Induced Diffusion Changes Revisited: Biophysical Modeling of the Water and NAA MR “Diffusion Signal”
Authors: Spees William M. , Sukstanskii Alex L. , Bretthorst G. Larry , Neil Jeffrey J. , Ackerman Joseph J.H. 
Published: April 2022

PurposeTo assess changes in intracellular diffusion as a mechanism for the reduction in water ADC that accompanies brain injury. Using NAA as a marker of neuronal cytoplasmic diffusion, NAA diffusion was measured before and after global ischemia (immediately postmortem) in the female Sprague–Dawley rat.MethodsDiffusion‐weighted PRESS spectra, with diffusion encoding in a single direction, were acquired from large voxels of rat brain gray matter in vivo and postischemia employing either pairs of pulsed half‐sine–shaped gradients (in vivo and postischemia, bmax = 19 ms/μm2) or sinusoidal oscillating gradients (in vivo only) with frequencies of 99.2–250 Hz. A 2D randomly oriented cylinder (neurite) model gave estimates of longitudinal and transverse diffusivities (DL and DT, respectively). In this model, DL represents the “free” diffusivity of NAA, whereas DT reflects highly restricted diffusion. Using oscillating gradients, the frequency dependence of DT [DT(ω)] gave estimates of the cylinder (axon/dendrite) radius.ResultsA 10% decrease in DL,NAA followed global ischemia, dropping from 0.391 ± 0.012 μm2/ms to 0.350 ± 0.009 μm2/ms. Modeling DT,NAA(ω) provided an estimate of the neurite radius of 1.0 ± 0.6 μm.ConclusionWhereas the increase in apparent intraneuronal viscosity suggested by changes in DL,NAA may contribute to the overall reduction in water ADC associated with brain injury, it is not sufficient to be the sole explanation. Estimates of neurite radius based on DT(ω) were consistent with literature values.
Localized MFS for three‐dimensional acoustic inverse problems on complicated domains
Authors: Chen Zengtao , Wang Fajie , Cheng Suifu , Wu Guozheng 
Published: April 2022

AbstractThis paper proposes a semi‐analytical and local meshless collocation method, the localized method of fundamental solutions (LMFS), to address three‐dimensional (3D) acoustic inverse problems in complex domains. The proposed approach is a recently developed numerical scheme with the potential of being mathematically simple, numerically accurate, and requiring less computational time and storage. In LMFS, an overdetermined sparse linear system is constructed by using the known data at the nodes on the accessible boundary and by making the remaining nodes satisfy the governing equation. In the numerical procedure, the pseudoinverse of a matrix is solved via the truncated singular value decomposition, and thus the regularization techniques are not needed in solving the resulting linear system with a well‐conditioned matrix. Numerical experiments, involving complicated geometry and the high noise level, confirm the effectiveness and performance of the LMFS for solving 3D acoustic inverse problems.
Subsequent malignant neoplasms in the pediatric age in retinoblastoma survivors in Argentina
Authors: Villanueva Gabriela , Sampor Claudia , Moreno Florencia , Alderete Daniel , Moresco Angelica , Pinto Natalia , Szijan Irene , Schaiquevich Paula , Felice María Sara , Rose Adriana , Zubizarreta Pedro , Sgroi Mariana , Fandiño Adriana , Chantada Guillermo 
Published: April 2022

AbstractBackgroundRetinoblastoma survivors in low‐ and middle‐income countries are exposed to high‐intensity treatments that potentially place them at higher risk of early subsequent malignant neoplasms (SMNs).MethodsWe followed 714 (403 [56.4%] nonhereditary and 311 [43.5%] hereditary) retinoblastoma survivors diagnosed from August 1987 to December 2016, up to the age of 16 years. We quantified risk of SMNs with cumulative incidence (CI) and standardized incidence ratios (SIR) analysis. Multivariate regression Cox model was used to determine the association of treatments and risk of SMNs.ResultsMedian follow‐up was of 9 years (range: 0.18–16.9) and 24 survivors (3.36%) developed 25 SMNs (n = 22 hereditary, n = 2 nonhereditary). SMNs included sarcomas (osteosarcomas, Ewing sarcomas, rhabdomyosarcomas; n = 12), leukemias (n = 5), and central nervous system tumors (CNS; n = 3). All cases of acute myeloid leukemia (AML) and most of Ewing sarcomas occurred within 5 years of retinoblastoma diagnosis. The type of SMN was the main indicator of mortality (five of five patients with leukemias, six of 12 with sarcomas, and zero of three with CNS tumors died). Compared to the general population, radiation increased the risk of Ewing sarcoma in hereditary survivors by 700‐fold (95% CI = 252–2422.6) and chemotherapy increased the risk of AML by 140‐fold (95% CI = 45.3–436). The CI of SMNs for hereditary survivors was 13.7% (95% CI = 8.4–22.1) at 15 years.ConclusionRetinoblastoma survivors from Argentina are at higher risk of developing SMNs early in life compared to the general Argentinean population, especially those treated with radiation plus chemotherapy. AML and Ewing sarcoma presented within 5 years of retinoblastoma diagnosis are associated with chemotherapy and radiation exposure.
Non‐isothermal DSC curing kinetics study of silicone‐modified epoxy/ABS/GO nanocomposite
Authors: Gholinezhad Farhad , Golhosseini Reza , Moini Jazani Omid 
Published: April 2022

AbstractIn this study, non‐isothermal curing kinetics of the prepared samples was studied using differential scanning calorimetry (DSC) to evaluate the effect of methyl phenyl silicone resin (MPS), acrylonitrile butadiene styrene (ABS), and graphene oxide (GO) on the cure reaction of epoxy resin. Chemical and microscopic structure of prepared nanocomposites was investigated using Fourier‐transform infrared spectrophotometry (FTIR) and scanning electron microscopy (SEM), respectively. Izod impact strength of modified epoxy resin with 5 phr MPS, 2 phr ABS, and 0.1 phr GO was about 53% higher than pure epoxy resin. Evaluation of activation energy (Ea) by Kissinger, Ozawa, FWO and Friedman methods showed that the presence of GO facilitates the curing reaction by reducing Ea about 30% which is due to the catalytic effect of hydroxyl groups presented on the surface of GO for epoxy ring opening. According to Friedman's plots, curing reaction remained autocatalytic for all of samples. The presence of GO increased the autocatalytic term of the reaction (n) from 0.26 to 0.32. Non‐isothermal DSC diagrams obtained from experimental data fitted well with data obtained from theoretical relations.
Recognizing pulmonary hypertension following pulmonary thromboendarterectomy: A practical guide for clinicians
Authors: Forfia Paul , Ferraro Bruce , Vaidya Anjali 
Published: April 2022

AbstractChronic thromboembolic pulmonary hypertension (CTEPH) is a form of pulmonary hypertension (PH) arising from pulmonary vascular obstruction at varying levels within the pulmonary vascular bed, due to chronic pulmonary emboli. The cornerstone of treatment for CTEPH is pulmonary thromboendarterectomy (PTE), a specialized surgery to remove the chronic vascular obstruction. At experienced centers, PTE leads to marked hemodynamic improvement and, in many cases, normalization of cardiopulmonary hemodynamics. However, increasing evidence supports the fact that a significant percentage of patients will have persistent PH after PTE. No consensus exists on the optimal approach to post‐PTE patient assessment, and often the most experienced CTEPH centers have little experience in the direct follow‐up care of the CTEPH patient post PTE. In this article, we will discuss a practical approach to patient assessment after PTE to help guide clinicians on how to recognize significant PH following PTE. In doing so, we identify the true phenotype of persistent PH post PTE so that appropriate patients can be further helped with the evolving therapies for the management of CTEPH.
Cyclodextrin‐Derived ROS‐Generating Nanomedicine with pH‐Modulated Degradability to Enhance Tumor Ferroptosis Therapy and Chemotherapy
Authors: Xu Meng , Zha Haidong , Han Run , Cheng Yaxin , Chen Jiamao , Yue Ludan , Wang Ruibing , Zheng Ying 
Published: April 2022

AbstractNowadays, destruction of redox homeostasis to induce cancer cell death is an emerging anti‐cancer strategy. Here, the authors utilized pH‐sensitive acetalated β‐cyclodextrin (Ac‐β‐CD) to efficiently deliver dihydroartemisinin (DHA) for tumor ferroptosis therapy and chemodynamic therapy in a synergistic manner. The Ac‐β‐CD‐DHA based nanoparticles are coated by an iron‐containing polyphenol network. In response to the tumor microenvironment, Fe2+/Fe3+ can consume glutathione (GSH) and trigger the Fenton reaction in the presence of hydrogen peroxide (H2O2), leading to the generation of lethal reactive oxygen species (ROS). Meanwhile, the OO bridge bonds of DHA are also disintegrated to enable ferroptosis of cancer cells. Their results demonstrate that these nanoparticles acted as a ROS generator to break the redox balance of cancer cells, showing an effective anticancer efficacy, which is different from traditional approaches.
Microindentation of Fluid‐Filled Cellular Domes Reveals the Contribution of RhoA‐ROCK Signaling to Multicellular Mechanics
Authors: DeOre Brandon J. , Baldwin‐LeClair Abigail , Tran Kiet A. , DaSilva Angelica , Byfield Fitzroy J. , Janmey Paul A. , Galie Peter A. 
Published: April 2022

AbstractCellular mechanics encompass both mechanical properties that resist forces applied by the external environment and internally generated forces applied at the location of cell–cell and cell–matrix junctions. Here, the authors demonstrate that microindentation of cellular domes formed by cell monolayers that locally lift off the substrate provides insight into both aspects of cellular mechanics in multicellular structures. Using a modified Hertz contact equation, the force–displacement curves generated by a micro‐tensiometer are used to measure an effective dome stiffness. The results indicate the domes are consistent with the Laplace–Young relationship for elastic membranes, regardless of biochemical modulation of the RhoA‐ROCK signaling axis. In contrast, activating RhoA, and inhibiting ROCK both alter the relaxation dynamics of the domes deformed by the micro‐tensiometer, revealing an approach to interrogate the role of RhoA‐ROCK signaling in multicellular mechanics. A finite element model incorporating a Mooney–Rivlin hyperelastic constitutive equation to describe monolayer mechanics predicts effective stiffness values that are consistent with the micro‐tensiometer measurements, verifying previous measurements of the response of cell monolayers to tension. Overall, these studies establish microindentation of fluid‐filled domes as an avenue to investigate the contribution of cell‐generated forces to the mechanics of multicellular structures.
Surface‐Engineered Ti3C2Tx with Tunable Work Functions for Highly Efficient Polymer Solar Cells
Authors: Hou Chunli , Huang Chengwen , Yu Huangzhong , Shi Shengwei 
Published: April 2022

AbstractTi3C2Tx, as a newly investigated 2D material, has gained great attention owing to its metallic conductivity, tunable work function (WF), and unique electrical property. However, its WF can be further adjusted to meet the needs of optoelectronic devices. Here, surface‐engineered Ti3C2Tx is fabricated with tunable WF by treating with ethanolamine and rhodium chloride (RhCl3). Ethanolamine treated Ti3C2Tx can induce the chemical adsorption of NH2 on Ti3C2Tx with hydrogen‐bonding, which causes the decreased WF, while chemical doping with RhCl3 leads to the improvement of WF, which is achieved by the downshift of Femi level of Ti3C2Tx. Moreover, the ethanolamine and RhCl3 can effectively passivate the vacancies of Ti. As such, the surface‐engineered Ti3C2Tx is more suitable as buffer layer for polymer solar cells (PSCs) by enhancing the interfacing characteristics of the Ti3C2Tx/active layer. The PSCs with engineered Ti3C2Tx for electron or hole transport layers can exhibit a power conversion efficiency of 15.88% or 15.54%. These efficiencies can be compared with those of devices with a conventional transport layer. This work provides a facile strategy to realize the work function tunability of Ti3C2Tx, and also shows that the tuned Ti3C2Tx has a certain application prospect in photovoltaic devices.
Self‐compressing object sequence for consistency maintenance in co‐editors
Authors: Cai Weiwei , He Fazhi , Yang Shangxu , Lv Xiao , Cheng Yuan 
Published: April 2022

AbstractCo‐editors are a class of human‐centered collaborative systems that allow multiple geographically dispersed people to freely and concurrently edit shared documents at the same time over networks. The most important building co‐editors technique is consistency maintenance. Even though OT (operational transformation) is a widely adopted consistency maintenance technique, researchers and practitioners have persistently explored alternative techniques to OT. One of the representative techniques is AST (Address Space Transformation), which replaces OT's transformation components with basic manipulation on an additional object sequence. However, the additional object sequence causes an unbounded metadata overhead problem. To solve the problem, this work proposes an optimized AST algorithm called ASTO, which is equipped with a specially designed self‐compressing object sequence. ASTO can automatically compress the object sequence and keep the metadata overhead under control. The effectiveness and feasibility of ASTO are verified by simulation experiments and a publicly accessible prototype system.
Trauma‐informed education for wholeness: Strategies for faculty & advisors
Authors: Imad Mays 
Published: April 2022

AbstractThe purpose of this article is to reflect upon how a trauma‐informed education is intimately connected with equity and justice. I will briefly describe the impacts of trauma on students, specifically on their sense of safety and belonging, and by extension, their ability to engage and learn. I will then offer suggestions for how we, as educators, can help mitigate the effects of such traumatic stress. I will use trauma‐informed principles to guide my recommendations.
Deepening crisis response: Addressing institutional trauma in student affairs and beyond
Authors: Shaw Bonds Mahauganee D. , Callier Durell M. 
Published: April 2022

AbstractWhat does it mean for the community to really recover when the (campus) community is built upon systemic racism and other forms of domination? How would the response look differently if these factors and histories were taken into consideration? Responding to campus disasters involves more than merely returning to daily operations; communities are vital to recovery. This article posits institutional policies and (in)actions as facilitators of trauma within minoritized subpopulations of the broader campus community, and offers guidance for an equity‐minded approach to campus crisis management.
The cost of professional helping in higher education
Authors: Lynch R. Jason 
Published: April 2022

AbstractIt is estimated that over half of college student affairs practitioners support students through traumatic life events on at least a monthly basis. This level of trauma exposure leaves professionals at risk of experiencing secondary traumatic stress (STS), or the distress that results from helping, or wanting to help, a person experiencing trauma. Unfortunately, little is known about the impact of this phenomenon within the context of student affairs work. This article seeks to shed light on the nature and impact of STS within the context of college student affairs work, as well as explore ways to identify and address the negative impacts of professional helping. The article ends with practical recommendations for individual practitioners, supervisors, organizational leaders, and the profession at‐large.
Phylogenetic and genetic characterization of influenza A H9N2 viruses isolated from backyard poultry in selected farms in Ghana
Authors: Kotey Erasmus Nikoi , Asante Ivy Asantewaa , Adusei‐Poku Mildred , Arjarquah Augustina , Ampadu Richard , Rodgers David , Nyarko Edward Owusu , Asiedu William , Dafeamekpor Courage , Wiley Michael R. , Mawuli Gifty , Obeng Richard Asomadu , Nyarko Stephen Ofori , Magnusen Vanessa , Kodua Emmanuel , Attram Naiki , Nimo‐Paintsil Shirley Cameron , Pratt Catherine , Fox Anne T. , Letizia Andrew , Ampofo William Kwabena 
Published: April 2022

AbstractIntroductionAvian influenza viruses (AIV) cause significant economic losses to poultry farmers worldwide. These viruses have the ability to spread rapidly, infect entire poultry flocks, and can pose a threat to human health. The National Influenza Centre (NIC) at the Noguchi Memorial Institute for Medical Research in collaboration with the Ghana Armed forces (GAF) and the U.S. Naval Medical Research Unit No. 3, Ghana Detachment (NAMRU‐3) performs biannual surveillance for influenza viruses among poultry at military barracks throughout Ghana. This study presents poultry surveillance data from the years 2017 to 2019.MethodologyTracheal and cloacal swabs from sick and healthy poultry were collected from the backyards of GAF personnel living quarters and transported at 4°C to the NIC. Viral ribonucleic acid (RNA) was isolated and analyzed for the presence of influenza viruses using real‐time polymerase chain reaction (PCR) assays. Viral nucleic acids extracted from influenza A‐positive specimens were sequenced using universal influenza A‐specific primers.ResultsInfluenza A H9N2 virus was detected in 11 avian species out of 2000 samples tested. Phylogenetic analysis of viral haemagglutinin (HA) protein confirms the possibility of importation of viruses from North Africa and Burkina Faso. Although the detected viruses possess molecular markers of virulence and mammalian host adaptation, the HA cleavage site anlaysis confirmed low pathogenicity of the viruses.ConclusionsThese findings confirm the ongoing spread of H9 viruses among poultry in Ghana. Poultry farmers need to be vigilant for sick birds and take the appropriate public health steps to limit the spread to other animals and spillover to humans.