bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomic analysis and ecofriendly enrichment of sunflower meal extract
Authors: do Nascimento Talita Pimenta , Ladeira Karine Campos , Bezerra Fernanda de Sousa , Santos Millena Cristina Barros , de Souza Thaiza Serrano Pinheiro , Cameron L.C. , Ferreira Mariana Simões Larraz , Koblitz Maria Gabriela Bello 
Published: September 2022

AbstractBACKGROUNDThe presence of phenolic compounds in sunflower is well reported in the literature; however, knowledge is scarce when it comes to the composition of other secondary metabolites in this species and their by‐products. This work evaluated, for the first time, the phytochemical composition of sunflower meal produced in Brazil. A combination of mixture design and central composite rotatable design 23 models was then applied to maximize the recovery of bioactive compounds using ecologically friendly solvents and concentrating by applying activated carbon, a sustainable adsorbent. The product of this extraction–concentration was also evaluated by an untargeted metabolomic approach using ultra‐performance liquid chromatography coupled to mass spectrometry.RESULTSA diverse and abundant profile of phenolic compounds was obtained from Brazilian sunflower meal: in total, 51 natural products were tentatively identified, 35 of which for the first time in sunflower. The sorption capacity of the activated charcoal, in the optimized process conditions, was effective in the separation and concentration of minority secondary metabolites. The ecofriendly extract proved to be enriched in plumberoside, p‐coumaric acid, and alkaloids.CONCLUSIONSInvestigation of the phytochemical profile of sunflower meal produced in Brazil pointed to several secondary metabolites reported for the first time in sunflower samples, including phenolic compounds, alkaloids, and terpenes. The use of activated charcoal in an alkaline medium as an adsorbent for the concentration of these phytochemicals, from an aqueous extract, generated a potentially cost‐effective, ecofriendly extract, enriched in minor metabolites, indicating a possible innovative way to selectively obtain these compounds from sunflower meal. © 2022 Society of Chemical Industry.
Effect of splenic transfer factor on the development of intestinal mucosal barrier in laying hens
Authors: Ma Junxing , Ma Baochen , Wang Zixu , Chen Yaoxing , Ma Ruiqin , Dong Yulan 
Published: September 2022

AbstractBACKGROUNDThe aim of this study was to investigate the effects of different doses of chicken spleen transfer factor (TF) on the structure of intestinal epithelial cells in different age groups. One‐day‐old White Leghorns laying hens were randomly divided into four groups: three groups were administered TF at different dosages (0.10, 0.25 or 1.00 mL) and a fourth group was set as control (administered saline, 1.00 mL). Using hematoxylin and eosin staining, high‐throughput sequencing, microbiota analysis, quantitative polymerase reaction and western blotting.RESULTSWe measured the effects of different doses of TF on the following: intestinal mucosal epithelial tissue morphology, intestinal mucosal epithelial barrier‐related gene expression profiles, and intestinal epithelial tight junction gene protein levels. The collected data show that TF can improve the absorption of nutrients by increasing villus height and crypt depth, and regulate intestinal flora disorders. Furthermore, we verified that the expression of the claudin and occludin tight junctions between intestinal epithelial cells was increased with TF. this research is very important for focusing on the structure and gene expression of intestinal tissues.CONCLUSIONThe results provide a scientific rationale for feeding and nutrition programs for green and healthy farming, as well as technical support to improve the production efficiency of the livestock and poultry breeding industry. © 2022 Society of Chemical Industry.
GO‐Al2O3 nanohybrids to enhance the anticorrosion performance of chemically bonded ceramic coatings
Authors: Guo Yongxin , Wang Lei , Sun Xue 
Published: September 2022

AbstractIn this study, nano‐alumina/graphene oxide (GO‐Al2O3) nanohybrids were synthesized and incorporated into a ceramic matrix to enhance the anticorrosion performance of chemically bonded ceramic coatings. The interaction between GO and nano‐Al2O3 was investigated using Fourier transform infrared spectroscopy, Raman spectroscopy, and scanning electron microscopy. Results showed that nano‐Al2O3 was successfully decorated on the surface of GO through chemical bonds, which improved the bonding strength between GO and the ceramic matrix through the reaction of the aluminum phosphate binder with nano‐Al2O3. The unique structures of the GO‐Al2O3 nanohybrids endowed the ceramic coatings with superior anticorrosion properties as compared to the untreated substrate and pure ceramic coatings. The best corrosion resistance of coatings was achieved when the content of the GO‐Al2O3 nanohybrids was 0.6 wt%, which led to the highest protection efficiency (93.4%) and the smallest corrosion current (icorr). The improvement in the corrosion resistance of the ceramic coatings was attributed to the excellent compatibility and dispersibility of the GO‐Al2O3 nanohybrids in the ceramic matrix. In addition, the greater bonding strength between the GO‐Al2O3 nanohybrids and ceramic matrix could enable more fracture energy to be consumed. This in turn could block or change the diffusion pathway of cracks, resulting in higher corrosion resistance.
Activities of Daily Living Are Improved by Inpatient Multimodal Complex Treatment for PD—a Real‐World Cohort Study
Authors: Ziegler Kerstin , Messner Michael , Paulig Mario , Starrost Klaus , Reuschenbach Bernd , Fietzek Urban M. , Ceballos‐Baumann Andres O. 
Published: September 2022

AbstractBackgroundThe multimodal complex treatment for Parkinson's disease (MCT) provides inpatient care by a multi‐disciplinary team for people with Parkinson's disease (PwP) in Germany.ObjectivesWe conducted a 5‐year real‐world mono‐center cohort study to describe the effectiveness of MCT in the full cohort and various subgroups and outcome predictors.MethodsWe collected an anonymized dataset between Jan 2015 and Dec 2019, involving N = 1773. The self‐reported MDS‐UPDRS part II was used as primary outcome, and clinical routine data for explanatory variables. PwP were categorized as responders or non‐responders according to a response of at least 3 points 4 weeks after discharge.ResultsN = 591 complete data records were available for statistical analyses. The full group improved by −2.4 points on the MDS‐UPDRS II (P = <0.0001). 47.7% (n = 282) and 52.3% (n = 309) were coded as responders and non‐responders, respectively. A clinically meaningful response was positively associated to age (χ2 = 11.07, P = 0.018), as well as baseline‐severity of the MDS‐UPDRS II (χ2 = 6.05, P = 0.048) and negatively associated to the presence of psychiatric disorder (χ2 = 3.9, P = 0.048) and cognitive dysfunction (χ2 = 7.29, P = 0.007). Logistic regression showed that baseline severity of the MDS‐UPDRS II predicted therapy success. PwP with moderate baseline‐severity had an about 2fold chance (OR 2.08; 95% CI 1.20–3.61; P = 0.009) and with severe an about 6fold chance (OR 5.92; 95% CI 2.76–12.68; P < 0.0001) to benefit clinically meaningful.DiscussionIn a naturalistic setting of a specialized Parkinson's center, MCT improved ADL disability of PwP at least 4 weeks after discharge. Moderately and severely impaired patients were more likely to achieve clinically meaningful responses.
Roses given, fragrance in hand: Charity law and corporate philanthropy—Evidence from a quasi‐natural experiment in China
Authors: Lu Shiyu , Cheng Bo 
Published: September 2022

AbstractThis study aims to investigate the impact of the 2016 Charity Law of the People's Republic of China on corporate philanthropy and its mechanism. Based on the difference‐in‐difference framework, empirical results show that the charity law has significantly increased the charitable donation level of firms with direct product–consumer contact rather than that in other firms. The additional analysis indicates that corporate self‐interest motives, but not altruistic motives, are ruled out as the mechanisms through which corporate philanthropy is delivered. Furthermore, a closer examination reveals that the charitable donation has not remarkably enhanced firms' operating performance, while the capital market gives these firms a higher valuation.
Interval Laplace transform and its application in production inventory
Authors: Das Subhajit , Rahman Md Sadikur , Shaikh Ali Akbar , Bhunia Asoke Kumar , Konstantaras Ioannis 
Published: September 2022

This work demonstrates the Laplace and inverse transforms of interval valued functions with exaggerating its necessary properties under interval flexibility. After proposing the formal definition interval Laplace transform (i.e., Laplace transform of interval valued functions), some of its important properties are derived. Thereafter, the sufficient condition for the existence of interval Laplace transforms is established. Then, some important results regarding switching points of interval Laplace transform are discussed and illustrated with some numerical examples. Finally, the definition of inverse transform of interval valued functions is proposed, and as an application, a production inventory model in interval uncertainty is studied using all of the proposed theoretical results.
Disease activity in chronic inflammatory demyelinating polyneuropathy: A comparative study of clinical and skin biopsy markers
Authors: Acarli Ayşe Nur Özdağ , Ünverengil Gökçen , Şirin Nermin Görkem , Çakar Arman , Durmuş Hacer , Parman Yeşim 
Published: September 2022

AbstractIntroduction/AimsEpidermal nerve fiber involvement in chronic inflammatory demyelinating neuropathy (CIDP) has been reported in a limited number of patients. We quantified small‐fiber involvement in a mixed cohort of patients with typical CIDP and CIDP variants to evaluate relationships with clinical outcome measures at different disease stages.MethodsIntraepidermal nerve fiber densities (IENFDs) were evaluated by skin punch biopsies of 23 patients with CIDP and 13 healthy controls at the forearm, thigh, and distal leg. Skin sections were optimally interpreted in all three regions in 16 CIDP patients and 10 age‐ and sex‐matched healthy controls. Statistical analysis was performed in these subjects.ResultsThe IENFDs in forearm, thigh, and distal leg were similar among seven typical CIDP and nine CIDP variants. IENFDs in those regions were significantly reduced in CIDP compared with healthy controls, with a moderate negative correlation with scores on the International Neuropathy Cause and Treatment (INCAT) Upper Limb Functional Disability Scale. The reduction in IENFD compared with controls was more remarkable in the distal leg. In clinically unstable CIDP patients, the IENFDs of distal leg and forearm were significantly reduced compared with stable CIDP patients and controls. Stable CIDP patients had significantly reduced IENFDs in distal leg and forearm compared with controls.DiscussionIn this exploratory study, we confirm that small fibers are also affected in CIDP. Larger studies are needed to explore longitudinal changes of IENFD in CIDP and its relation to disease stage.
Evidence of nerve hypertrophy in patients with inclusion body myositis on lower limb MRI
Authors: Elmansy Mostafa , Morrow Jasper M. , Shah Sachit , Fischmann Arne , Wastling Stephen , Reilly Mary M. , Hanna Michael G. , Helmy Eman Mohamed , El‐Essawy Saleh Saleh , Thornton John S. , Yousry Tarek A. 
Published: September 2022

AbstractIntroduction/aimsInclusion body myositis (IBM) is a myopathic condition but in some patients has been associated with an axonal length‐dependent polyneuropathy. In this study, we quantified the cross‐sectional area of the sciatic and tibial nerves in patients with IBM comparing with Charcot–Marie–Tooth disease type 1A (CMT1A) and healthy controls using magnetic resonance neurography (MRN).MethodsMRN of the sciatic and tibial nerves was performed at 3T using MPRAGE and Dixon acquisitions. Nerve cross‐sectional area (CSA) was measured at the mid‐thigh and upper third calf regions by an observer blinded to the diagnosis. Correlations were performed between these measurements and clinical data.ResultsA total of 20 patients with IBM, 20 CMT1A and 29 healthy controls (age‐ and sex‐matched) were studied. Sciatic nerve CSA was significantly enlarged in patients with IBM and CMT1A compared to controls (sciatic nerve mean CSA 62.3 ± 22.9 mm2 (IBM) vs. 35.5 ± 9.9 mm2 (controls), p < 0.001; and 96.9 ± 35.5 mm2 (CMT1A) vs. 35.5 ± 9.9 mm2 (controls); p < 0.001). Tibial nerve CSA was also enlarged in IBM and CMT1 patients compared to controls.DiscussionMRN reveals significant hypertrophy of the sciatic and tibial nerves in patients with IBM and CMT1A compared to controls. Further studies are needed to correlate with neurophysiological measures and assess whether this finding is useful diagnostically.
On the evaluation of general sparse hybrid linear solvers
Authors: Farea Afrah , Çelebi M. Serdar 
Published: September 2022

AbstractGeneral sparse hybrid solvers are commonly used kernels for solving wide range of scientific and engineering problems. This work addresses the current problems of efficiently solving general sparse linear equations with direct/iterative hybrid solvers on many core distributed clusters. We briefly discuss the solution stages of Maphys, HIPS, and PDSLin hybrid solvers for large sparse linear systems with their major algorithmic differences. In this category of solvers, different methods with sophisticated preconditioning algorithms are suggested to solve the trade off between memory and convergence. Such solutions require a certain hierarchical level of parallelism more suitable for modern supercomputers that allow to scale for thousand numbers of processors using Schur complement framework. We study the effect of reordering and analyze the performance, scalability as well as memory for each solve phase of PDSLin, Maphys, and HIPS hybrid solvers using large set of challenging matrices arising from different actual applications and compare the results with SuperLU_DIST direct solver. We specifically focus on the level of parallel mechanisms used by the hybrid solvers and the effect on scalability. Tuning and Analysis Utilities (TAU) is employed to assess the efficient usage of heap memory profile and measuring communication volume. The tests are run on high performance large memory clusters using up to 512 processors.
Communication in home care—A feasibility study of an educational intervention in self‐efficacy and job satisfaction
Authors: Gustafsson Tanja , Sundler Annelie J. , Hedén Lena , Lindberg Elisabeth , Maurin Söderholm Hanna 
Published: September 2022

AbstractAimTo explore the feasibility of evaluating a novel educational intervention on person‐centered communication for nursing assistants (NAs) in home care.DesignA feasibility study with pre‐ and post‐assessments.MethodsFeasibility was assessed pre‐ and post‐intervention, including evaluation of data collection procedures, completion rates and missing data in two questionnaires: Self‐efficacy Questionnaire measuring communication skills and Measure of Job Satisfaction, analysed descriptively and statistically.ResultsThe questionnaires were feasible and acceptable for the NAs to complete and understand. The pre‐ and post‐assessments showed 83% and 61% completion rates, respectively, and a low proportion of missing data. Barriers for not participating in data collection were stress caused by staff shortages and high workload. Preliminary analysis of the questionnaires showed no significant difference pre‐ and post‐intervention, even though an overall tendency of increased communication self‐efficacy was observed. The NAs' self‐efficacy ratings also revealed a ceiling effect.
Notes on early childhood diets in early modern Oulu, Finland, based on the stable isotope case studies of archeological dentin
Authors: Väre Tiina , Lipkin Sanna , Núñez Milton 
Published: September 2022

AbstractIn mid‐18th‐century Sweden, the newly enhanced census records revealed higher‐than‐expected infant mortality rates in certain regions of the kingdom. This convinced contemporary elite men of common women deliberately refusing to breastfeed out of vanity and lack of care. One of the worst regions in terms of infant mortality was the province of Ostrobothnia, located in the area of what is now Finland. To explore the allegations, we measured the carbon (δ13C) and nitrogen (δ15N) stable isotope ratios in the collagen of incremental crown dentin segments of the permanent first molars (M1) of six individuals excavated from the early modern churchyard of the town of Oulu, Ostrobothnia. The results do not directly support the worries over the lack of breastfeeding but imply a variety of related practices in Oulu at the time.
Collective sensemaking within institutions: Control of the COVID‐19 epidemic in Vietnam
Authors: Pham Chuong H. , Nguyen Thang V. , Bach Thang N. , Le Canh Q. , Nguyen Hung V. 
Published: September 2022

AbstractHow people make initial and collective sense under crises remains unanswered. This paper addresses this question using the control of COVID‐19 in Vietnam as a case study. Our results suggest that sensemaking under crises is influenced by an institutional propensity for prevention that has developed gradually over time. Local governments play a vital role in fostering collective sensemaking which enables concerted actions in epidemic control. However, biases are inherent in sensemaking, including a delay in access to vaccine and a violation of privacy. For policy makers, this study suggests that developing specific prevention policies and programs, building large‐scale coordination capacity, and promoting local initiatives are necessary for coping with epidemics. For theory development, the study explores how institutions condition sensemaking and specifies several mechanisms in which local authorities could facilitate collective sensemaking in crises.
Polylactic acid/silk fibroin composite hollow fibers as excellent controlled drug release systems
Authors: Gang Hanlin , Wang Han , Ma Sitian , Wang Chaorong , Bian Lixing , Wang Zonglei , Zhou Yingshan , Gu Shaojin , Liu Xin , Xu Weilin , Zhuang Yan , Yang Hongjun 
Published: September 2022

AbstractPolylactic acid (PLA) and silk fibroin (SF) have been widely used in biomedical applications because of their excellent biocompatibility and degradability. In this study, PLA and SF were used as raw materials to prepare hollow fibers with a skin‐core structure by wet spinning technology. Scanning electron microscopy observations revealed that the structure of hollow fibers became increasingly uniform with increasing silk fibroin mass fraction. Tensile test results showed that with the increase of silk fibroin content, the elastic modulus of hollow fibers decreased and their tensile properties improved. The results of hollow fibers degradation experiments revealed that increasing the content of silk fibroin can effectively shorten the degradation time of hollow fibers. Ultraviolet spectrophotometry was used to measure the absorbance of tetracycline hydrochloride in phosphate buffer saline and calculate its release rate in hollow fibers with different silk fibroin contents, the result is HFs‐9 > HFs‐7 > HFs‐0 > HFs‐5 > HFs‐3. The PLA/SF controlled drug release system has precise controlled release of the drug, realizes the separation of the drug from the controlled release system, and solves the problem of sudden drug release. In addition, the controlled release system is non‐toxic, degradable, and has excellent mechanical properties.
Satisfaction and access to care for adults and adolescents with sickle cell disease: ASCQ‐Me quality of care and the SHIP‐HU study
Authors: Sisler India , McClish Donna K. , Valrie Cecelia , Villella Anthony , Smith Wally R. 
Published: September 2022

AbstractA lack of adult sickle cell providers has long been blamed for poor satisfaction and access to specialty care for adults with sickle cell disease (SCD). We were interested in comparing how adolescent and adult patients already in established SCD centers perceived access and quality of care. Hydroxyurea‐eligible patients aged 15 years and older were enrolled in the Start Healing in Patients with Hydroxyurea trial, which required them to be affiliated with a SCD specialist. Patients were seen in one of three adult‐oriented specialty clinic sites or one of three pediatric‐oriented sites. At baseline, patients completed the Adult Sickle Cell Quality of Life Measurement Information System measure as part of a survey battery. Patients treated at adult clinic sites reported being less able to get timely ambulatory appointments (p = .004). They reported emergency department (ED) wait times of >1 h far more often (47.7 vs. 19.3%, p = .0048). They reported less overall satisfaction with care (7.47 vs. 8.77, p < .0001), and less satisfaction with care in the ED (2.88 vs. 3.4, p = .0068. Ambulatory satisfaction was no different between pediatric site versus adult site patients. Poorer systems of care appeared to underlie reported differences, rather than differences in biopsychosocial determinants. Even among specialty‐care‐affiliated SCD patients, those seen in adult clinics reported worse access to care and lower satisfaction with care than patients seen in pediatric clinics. In addition to increasing the number of adult SCD providers and better preparing pediatric SCD patients to transfer to adult programs, SCD clinical caregivers must also improve aspects of adult care quality to meet reasonable patient expectations of timeliness and interpersonal aspects of care quality.
Low‐dose acyclovir for prophylaxis of varicella‐zoster virus reactivation after hematopoietic stem cell transplantation in children
Authors: Tatebe Yasuhisa , Ushio Soichiro , Esumi Satoru , Sada Hikaru , Ochi Motoharu , Tamefusa Kosuke , Ishida Hisashi , Fujiwara Kaori , Kanamitsu Kiichiro , Washio Kana , Katsube Risa , Murakawa Kiminaka , Zamami Yoshito 
Published: September 2022

AbstractBackgroundVaricella‐zoster virus (VZV) reactivation is a serious complication of hematopoietic stem cell transplantation (HSCT). Although low‐dose acyclovir can prevent VZV reactivation after HSCT in adults, the efficacy of a dose of acyclovir lower than the recommended dose, such as 60–80 mg/kg/day in children, is unclear. In this study, we aimed to evaluate the incidence of VZV reactivation after HSCT during and after low‐dose acyclovir administration for preventing VZV reactivation in children.MethodsThis single‐center retrospective study included children aged ≤15 years who received oral acyclovir (at 15 mg/kg/day) to prevent VZV reactivation after HSCT. We examined the cumulative incidence of VZV reactivation after HSCT, during and after prophylactic acyclovir administration.ResultsFifty‐three eligible patients were included in this study, of whom 37 underwent allogeneic HSCT. The median duration of prophylactic acyclovir therapy was 264 days (range: 69–1140 days). VZV reactivation occurred in 13 patients (24.5%, 95% confidence interval [CI]: 14.9–37.6). The cumulative incidence of VZV reactivation 1 and 2 years after HSCT was 6.26% (95% CI: 1.60–15.5) and 20.9% (95% CI: 10.3–34.0), respectively. While only one patient developed VZV reactivation during the administration of prophylactic acyclovir, the cumulative incidence of VZV reactivation increased to 24.2% (95% CI: 12.5–38.0) 1 year after the cessation of acyclovir.ConclusionLow‐dose acyclovir (15 mg/kg/day) could be effective for preventing VZV reactivation after HSCT in children because VZV reactivation seldom occurs during the administration of 15 mg/kg/day acyclovir.