bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep‐learning‐based classification of desmoplastic reaction on H&E predicts poor prognosis in oesophageal squamous cell carcinoma
Authors: Kouzu Keita , Nearchou Ines P , Kajiwara Yoshiki , Tsujimoto Hironori , Lillard Kate , Kishi Yoji , Ueno Hideki 
Published: June 2022

AimsDesmoplastic reaction (DR) categorisation has been shown to be a promising prognostic factor in oesophageal squamous cell carcinoma (ESCC). The usual DR evaluation is performed using semiquantitative scores, which can be subjective. This study aimed to investigate whether a deep‐learning classifier could be used for DR classification. We further assessed the prognostic significance of the deep‐learning classifier and compared it to that of manual DR reporting and other pathological factors currently used in the clinic.Methods and resultsFrom 222 surgically resected ESCC cases, 31 randomly selected haematoxylin–eosin‐digitised whole slides of patients with immature DR were used to train and develop a deep‐learning classifier. The classifier was trained for 89 370 iterations. The accuracy of the deep‐learning classifier was assessed to 30 unseen cases, and the results revealed a Dice coefficient score of 0.81. For survival analysis, the classifier was then applied to the entire cohort of patients, which was split into a training (n = 156) and a test (n = 66) cohort. The automated DR classification had a higher prognostic significance for disease‐specific survival than the manually classified DR in both the training and test cohorts. In addition, the automated DR classification outperformed the prognostic accuracy of the gold‐standard factors of tumour depth and lymph node metastasis.ConclusionsThis study demonstrated that DR can be objectively and quantitatively assessed in ESCC using a deep‐learning classifier and that automatically classed DR has a higher prognostic significance than manual DR and other features currently used in the clinic.
Predicting the loss to follow‐up (LTFU) of HIV/AIDS patients in China using a recency‐frequency (RF) model
Authors: Li Min , Wang Qunwei 
Published: June 2022

AbstractBackgroundWe constructed a recency‐frequency (RF) model for predicting the loss to follow‐up (LTFU) in HIV/AIDS patients in China.MethodsData on HIV/AIDS outpatients in the research unit from 1 August 2009 to 30 September 2020 and from 1 October to 31 December 2020 were exported as the observation and prediction datasets, respectively. The classic recency‐frequency‐monetary (RFM) model was expanded into RFm, RF, RFL and RFmL models. In the observation dataset, the best predictive model was obtained using k‐means clustering and C5.0 verification. Then, two rounds of k‐means modelling were performed on the best model: data with R ≤ 6 months were retained, randomly divided into a training set (70%) and a testing set (30%) and used to perform the second round of modelling to subdivide the churn and non‐churn patients. Next, an ANN algorithm was used to predict LTFU, and the confusion matrix with prediction datasets was constructed.ResultsThe observation and prediction datasets included 16 949 and 10 748 samples, respectively. The RF model with three clusters and a quality of 0.82 was the best predictive model. From the observation set, 13 799 samples were retained, and the model accuracy was 100% on the training and testing sets. These 13 799 samples were subdivided into 1563 samples of churn patients and 12 216 samples of non‐churn patients. The accuracy of ANN prediction was 99.89%. The accuracy and precision of the confusion matrix were 85.41% and 99.76%, respectively.ConclusionThe RF model is effective in predicting the LTFU of HIV/AIDS patients in China and preventing its occurrence.
Un siècle de recherche sur le monde du travail: un regard historique sur la Revue internationale du Travail, 1921‐20211
Authors: HOEHTKER Dorothea 
Published: June 2022

RésuméCet article est consacré à l'histoire de la Revue internationale du Travail, publication périodique majeure de l'Organisation internationale du Travail (OIT), créée en 1921, en vertu de l'article 396 du Traité de Versailles de 1919. L'autrice examine, sous divers angles, la transformation de la Revue, périodique institutionnel polyvalent devenu revue académique moderne, notamment son évolution institutionnelle, le rôle des rédacteurs qui l'ont dirigée et les profils de ses auteurs. Elle étudie la contribution de la Revue à d'importants débats aca‐démiques et politiques, ainsi que son rôle pour l'OIT, en situant dans une perspective historique le contenu, les sujets et le champ géographique de près de 3 000 articles signés publiés à ce jour.
Immune responses to Sinopharm/BBIBP‐CorV in individuals in Sri Lanka
Authors: Jeewandara Chandima , Aberathna Inoka Sepali , Pushpakumara Pradeep Darshana , Kamaladasa Achala , Guruge Dinuka , Wijesinghe Ayesha , Gunasekera Banuri , Tanussiya Shyrar , Kuruppu Heshan , Ranasinghe Thushali , Dayarathne Shashika , Dissanayake Osanda , Gamalath Nayanathara , Ekanayake Dinithi , Jayamali Jeewantha , Jayathilaka Deshni , Dissanayake Madushika , Madusanka Deshan , Jayadas Tibutius Thanesh , Mudunkotuwa Anushika , Somathilake Gayasha , Harvie Michael , Nimasha Thashmi , Danasekara Saubhagya , Wijayamuni Ruwan , Schimanski Lisa , Rijal Pramila , Tan Tiong K. , Dong Tao , Townsend Alain , Ogg Graham S. , Malavige Gathsaurie Neelika 
Published: June 2022

AbstractAs there are limited data of the immunogenicity of the Sinopharm/BBIBP‐CorV in different populations, antibody responses against different SARS‐CoV‐2 variants of concern and T cell responses, we investigated the immunogenicity of the vaccine, in individuals in Sri Lanka. SARS‐CoV‐2‐specific antibodies were measured in 282 individuals who were seronegative at baseline, and ACE2 receptor blocking antibodies, antibodies to the receptor‐binding domain (RBD) of the wild‐type (WT), alpha, beta and delta variants, ex vivo and cultured IFNγ ELISpot assays, intracellular cytokine secretion assays and B cell ELISpot assays were carried out in a sub cohort of the vaccinees at 4 and 6 weeks (2 weeks after the second dose). Ninety‐five percent of the vaccinees seroconverted, although the seroconversion rates were significantly lower (p < 0.001) in individuals >60 years (93.3%) compared to those who were 20–39 years (98.9%); 81.25% had ACE2 receptor blocking antibodies at 6 weeks, and there was no difference in these antibody titres in vaccine sera compared to convalescent sera (p = 0.44). Vaccinees had significantly less (p < 0.0001) antibodies to the RBD of WT and alpha, although there was no difference in antibodies to the RBD of beta and delta compared to convalescent sera; 27.7% of 46.4% of vaccinees had ex vivo IFNγ and cultured ELISpot responses respectively, and IFNγ and CD107a responses were detected by flow cytometry. Sinopharm/BBIBP‐CorV appeared to induce a similar level of antibody responses against ACE2 receptor, delta and beta as seen following natural infection.
Characterization of the immune regulatory property of CD22+CD9+ B cells
Authors: Yang Gui , Suo Limin , Hu Suqin , Liu Huazhen , Wang Xinxin , Xiao Xiaojun , Liu Jie , Zeng Xianhai , Hong Jingyi , Guan Li , Xue Jinmei , Yang Pingchang 
Published: June 2022

AbstractImmunodisruptive homeostasis is recognized in allergic disorders. The mechanism of restoration of immunologic homeostasis in the body is not fully understood. Galectin‐9 (Gal9) and CD22 have immune regulatory functions. The goal of this study is to test the role of CD22+ CD9+ B regulatory cells in immune homeostasis the body. A much smaller amount of IL‐10 in B10 cells was detected in patients with allergic rhinitis (AR) in contrast to healthy subjects. The IL‐10 expression levels in B10 cells were positively correlated with the CD22 expression. CD22 mediated the effects of Gal9 on the enhanced expression of IL‐10 in AR B10 cells. Gal9 overcame the refractory induction of IL‐10 in B‐cells of AR subjects. The immune regulatory ability of AR B10 cells could be restored by Gal9. Combination of Gal9 and SIT induced and activated antigen‐specific B10 cells. The B10 cells of Gal9/specific immunotherapy‐treated AR mice showed immunosuppressive functions on T‐cell activities and induction of type 1 regulatory T cells in an antigen‐specific manner. Administration of Gal9 potentiated the effects of specific immunotherapy in mice with AR. In summary, a fraction of regulatory B cells, the CD19+ CD22+ CD9+ B cells, was characterized in the present study. CD22 mediates the effects of Gal9 to promote immunotherapy for allergic diseases by inducing B10 cells. In an antigen‐specific manner, the B10 cells suppressed CD4+ T cell activities, and alleviated experimental AR.
The way digitalization is impacting international financial markets: Stock price synchronicity
Authors: Chen Chen , Moeini Gharagozloo M. Mahdi , Darougar Layla , Shi Lei 
Published: June 2022

AbstractThis paper investigates whether and how the development level of a country's digital economy affects stock price synchronicity. The results indicate that countries with high levels of digital economy development exhibit low stock price synchronicity. Additionally, by decomposing stock price synchronicity into systematic and firm‐specific stock return variations, we find that systematic (firm‐specific) variations of stock returns decrease (increase) with the level of a country's digitalization. These findings shed light on the future trend of stock price synchronicity in financial markets around the world and support the information‐based interpretation of stock price synchronicity.
Accuracy of genomic prediction of maternal traits in pigs using Bayesian variable selection methods
Authors: Kjetså Maria V. , Gjuvsland Arne B. , Nordbø Øyvind , Grindflek Eli , Meuwissen Theo 
Published: June 2022

AbstractThe aim of this study was to compare three methods of genomic prediction: GBLUP, BayesC and BayesGC for genomic prediction of six maternal traits in Landrace sows using a panel of 660 K SNPs. The effects of different priors for the Bayesian methods were also investigated. GBLUP does not take the genetic architecture into account as all SNPs are assumed to have equally sized effects and relies heavily on the relationships between the animals for accurate predictions. Bayesian approaches rely on both fitting SNPs that describe relationships between animals in addition to fitting single SNP effects directly. Both the relationship between the animals and single SNP effects are important for accurate predictions. Maternal traits in sows are often more difficult to record and have lower heritabilities. BayesGC was generally the method with the higher accuracy, although its accuracy was for some traits matched by that of GBLUP and for others by that of BayesC. For piglet mortality within 3 weeks, BayesGC achieved up to 9.2% higher accuracy. For many of the traits, however, the methods did not show significant differences in accuracies.
Characteristics and antimicrobial activity of microfluidized clove essential oil nanoemulsion optimized using response surface methodology
Authors: Pilong Puncharat , Chuesiang Piyanan , Mishra Dharmendra K. , Siripatrawan Ubonrat 
Published: June 2022

AbstractClove essential oil nanoemulsion with optimal antimicrobial activity and stability was formulated and analyzed using response surface methodology with a central composite design (CCD). The optimal clove oil nanoemulsion was obtained from a microfluidizer (10,000 psi of operating pressure) of 1% (v/v) clove oil and 3% (v/v) of Tween® 80 (surfactant), with a droplet size of 30.76 nm, 0.179 polydispersity index (PDI), −50.01 mV Zeta potential, and 7.81 cP viscosity. It also exhibited good stability against particle aggregation and phase separation during 48 h of storage at 5°C. Clove essential oil nanoemulsion had higher amount of eugenol, but lower amount of benzyl alcohol and caryophyllene than those contained in bulk oil. The clove oil nanoemulsion exhibited better antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa when compared to clove oil. Bacterial cell morphological destruction caused by clove oil nanoemulsion or clove oil was also observed using a scanning electron microscope and energy dispersive x‐ray spectrometer (SEM‐EDS). The results suggested that the fabrication of clove essential oil into nanoemulsion improved its antimicrobial activity and has the potential to be used as a natural preservative for food applications.Novelty Impact StatementThe experiments in this research were designed to determine the feasibility of using the clove oil nanoemulsion as antimicrobial agent directly in food and its stability if used under different food processing conditions, storage, or usages. Our study is, however, not only the first to optimize the important factors required to formulate antimicrobial clove essential oil nanoemulsion using microfluidization but also the first to report the chemical stability of clove essential oil after nanoemulsion formation and storage. In addition, the bacterial cell morphology was visualized using a scanning electron microscope and energy dispersive x‐ray spectrometer (SEM‐EDS) to verify the antimicrobial efficiency of clove essential oil nanoemulsion, clove essential oil, and kanamycin sulfate (as control), which has never been reported in the literature.
Quantitative analysis of 3D cellular geometry and modelling of the Arabidopsis embryo
Authors: Yoshida Saiko , Weijers Dolf 
Published: June 2022

AbstractAs many multicellular organisms, land plants start their life as a single cell, which forms an embryo. Embryo morphology is relatively simple, yet comprises basic tissues and organs, as well as stem cells that sustain post‐embryonic development. Being condensed in both time and space, early plant embryogenesis offers an excellent window to study general principles of plant development. However, it has been technically challenging to obtain high spatial microscopic resolution, or to perform live imaging, that would enable an in‐depth investigation. Recent advances in sample preparation and microscopy now allow studying the detailed cellular morphology of plant embryos in 3D. When coupled to quantitative image analysis and computational modelling, this allows resolving the temporal and spatial interactions between cellular patterning and genetic networks. In this review, we discuss examples of interdisciplinary studies that showcase the potential of the early plant embryo for revealing principles underlying plant development.
Assessment of health‐related quality of life in patients with frontal fibrosing alopecia
Authors: Varghaei Aida , Rostami Anahita , Yarmohamadi Mahsa , Mahmoudi Hamidreza , Balighi Kamran , Daneshpazhooh Maryam 
Published: June 2022

AbstractBackgroundFrontal fibrosing alopecia (FFA) is a primary patterned cicatricial alopecia with different manifestations.AimsIts incidence is increasing worldwide. Like other types of alopecia, FFA can affect patients' health‐related quality of life (HRQOL). However, this effect has been rarely discussed. This study was designed to evaluate HRQOL in patients with FFA.MethodsIn this cross‐sectional study, 49 patients with confirmed FFA were asked to complete Dermatology Life Quality Index (DLQI) and the 36‐Item Short Form Survey (SF‐36) questionnaires. Disease severity was evaluated with the Frontal Fibrosing Alopecia Severity Score Index (FFASI).ResultsSignificant relation between SF‐36 scores and other covariants was not detected. According to the DLQI, most of the patients (54%) had impaired HRQOL, which was of low grade for most of them (84%). Patients with face papules and patients who were in the group of nail, limb, and flexural involvement had significantly lower HRQOL (p‐value 0.03).ConclusionWe found that FFA negatively impacts HRQOL, which was more pronounced in patients with involvement of other ostensible areas.
The first broad replication study of SNPs and a pilot genome‐wide association study for androgenetic alopecia in Asian populations
Authors: Kim In‐Young , Kim Ji‐Hye , Choi Ja‐Eun , Yu So‐Jin , Kim Joo Hee , Kim Soon Rye , Choi Mi Soo , Kim Myung Hwa , Hong Kyung‐Won , Park Byung‐Cheol 
Published: June 2022

AbstractBackgroundMany candidate genes for androgenetic alopecia (AGA) have been identified in studies of the Caucasians and some Asian populations.AimsThis study aimed to confirm the known susceptibility genes reported in previous studies and find additional candidate genes for high‐risk individuals for AGA in Korean population.Patients/MethodsWe recapitulated the previously reported SNPs and identified the novel Korean AGA risk genetic variants using a Korean hospital‐based AGA case and control samples. The population was consisting of 494 individuals (275 AGA cases and 146 controls). Using the 800 K SNPs of precision medical research array (PMRA SNP microarray chip) and imputation‐based SNPs, 12 previous GWAS reports for AGA and a total of 62 160 SNPs were examined in our study samples. Also, we conducted the genome‐wide association study (GWAS) by the logistic regression analyses for AGA cases and controls with controlling the age as the covariates.ResultsAmong the 62 160 SNPs, a total of 1143 SNPs in 76 gene regions showed weak replication tendency with the p‐values <0.05 and same direction of effects. Additionally, the GWAS results showed 110 SNPs in 13 independent regions with the suggestive p‐values <1.00 × 10−5. The most significantly replicated SNP resided on chromosome 20, which were similar to other AGA replication studies including Chinese study. The GWAS identified two SNPs (rs11010734 and rs2420640) increasing the risk for AGA in our study population.ConclusionsOur study would be a reference of the non‐European studies to better understand AGA in different populations and ancestral contexts.
Effects of scar massage on burn scars: A systematic review and meta‐analysis
Authors: Lin Tsai Rung , Chou Fan‐Hao , Wang Hsiu‐Hung , Wang Ruey‐Hsia 
Published: June 2022

AbstractAims and objectivesThis study explored the physical and psychological effects of scar massage on burn patients.BackgroundHypertrophic scar development is highly prevalent following burn injuries. Scar massage may have physical and psychological effects, although evidence of its effectiveness for burn scar improvement remains inconsistent.DesignA systematic review and meta‐analysis of randomised controlled trials and quasi‐experimental trials.MethodsThis study was conducted following the Centre of Reviews and Dissemination guidelines and the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement. Cochrane Library, Web of Science, Cumulative Index to Nursing and Allied Health Literature, PubMed, EMBASE, and Chinese Electronic Periodical Services were searched for studies published between January 1990 and February 2022. Quality was assessed using the Joanna Briggs Institute (JBI) Appraisal Checklist. The final recommendation strength was assessed according to the JBI recommendation rating. A meta‐analysis was performed using Review Manager Version 5.4 software with a random‐effect model.ResultsSeven studies (420 participants) investigating scar massage for burn patients were included. The scar massage sessions lasted 5–30 min and were delivered by massage therapists 1–3 times a week for 12 weeks. Overall, scar massage decreased pain levels (standardised mean difference [SMD]: −2.39; 95% confidence interval [CI]: −3.96 to −0.83), improved scar thickness (mean difference: ‐0.05; 95% CI: −0.1 to −0.0), reduced pruritus (SMD: ‐1.89; 95% CI: −2.95 to −0.82) and reduced anxiety (SMD: ‐1.52; 95% CI: −2.73 to −0.32), but no significant effect on depression(SMD: ‐0.92; 95% CI:‐2.28 to 0.44).ConclusionsThe meta‐effects of scar massage among burn patients are significantly improved scar formation and reduced pruritus and anxiety. Providing scar massage is feasible and effective for burn patients. Future research should evaluate its long‐term effects.Relevance to clinical practiceScar massage is relatively convenient and effective in preventing and alleviating hypertrophic burn scarring. Further research can provide detailed suggestions for effective scar massage implementation.
Work from home and parenting: Examining the role of work‐family conflict and gender during the COVID‐19 pandemic
Authors: Bernhardt Janine , Recksiedler Claudia , Linberg Anja 
Published: June 2022

AbstractMany employers introduced or expanded working from home (WFH) in response to increasing infection rates after the onset of the COVID‐19 pandemic. Whether WFH enhances or depletes parents’ resources for their children is still an open question. Drawing on contextual models of parenting and demands‐resources approaches, we examine how WFH during the early stages of the COVID‐19 pandemic was linked to changes in responsive and harsh parenting, particularly in light of pandemic‐related increases in work‐to‐family conflicts (WFC). We further investigate gender differences in these associations. Our analyses draw on a sample of working parents from a large‐scale German family survey conducted in 2019 and a COVID‐19 follow‐up from 2020. Results from first difference regression models in combination with Heckman's sample selection method revealed strongly gendered patterns of changes in parenting. Specifically, responsive parenting decreased and harsh parenting increased only among mothers who did not work from home. In addition, WFH buffered increased spillovers from WFC on declines in responsive parenting among mothers. In contrast, fathers’ parenting remained largely unaffected by pandemic‐related changes in their work situation. We conclude that WFH can be a resource gain because it seems to have relieved some pandemic‐related parenting strain for mothers. Yet as a consequence, it may have reinforced gendered patterns of childcare. We discuss implications for policymakers and support services for families. We also place a special emphasis on those who are not able to work from home because this seems to have increased the risk that high work demands impaired their parenting during the early stages of the pandemic.