bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectory tracking for underactuated surface vessels with time delays and unknown control directions
Authors: Chen Hua , Chen Yun , Wang Mengqi 
Published: February 2022

AbstractThe problem of trajectory tracking control for underactuated surface vessels with time‐delays, model uncertainty and unknown control directions has been considered in this paper. Firstly, an integration time delayed sliding mode controller is proposed, which decomposes the underactuated non‐linear system into a cascading system consisting of a kinematics subsystem and a dynamics subsystem. Secondly, an adaptive backstepping control method for the heading angle system is proposed, which can drive the heading angle error into a preset interval. Then the Bouc‐wen model is used to describe the hysteresis of the system, Nussbaum gain function is adopted to deal with unknown control directions, and the adaptive controller is designed by combining error transformation with Lyapunov function. Furthermore, a suitable Lyapunov‐Krasovsky function is selected to analyse and prove the global stability of the closed‐loop system. Finally, some numerical simulations show the effectiveness of the presented control methods.
Torque ripple reduction of brushless DC motor with convex arc‐type permanent magnets based on robust optimization design
Authors: Feng Haichao , Zhang Sheng , Wei Jinsong , Xu Xiaozhuo , Gao Caixia , Ai Liwang 
Published: February 2022

AbstractThe mass production of the motors causes tolerance of shape and dimension, deviation of permanent magnet remanence and rotor eccentricity error, which affect the cogging torque and torque ripple amplitude and performance consistency. In order to reduce the torque ripple of the motor in the actual condition, the robustness optimization is performed in the paper. Firstly, an improving convex arc type permanent magnet structure is adopted to improve air gap flux density and suppress the cogging torque. Secondly, the structure parameters of the magnetic pole are selected as optimization variables, and the magnetization angle, remanence and position of the permanent magnet, static and dynamic rotor eccentricity are considered as noise factors. To improve the overall robustness of the motor under different operating conditions, the dynamic Taguchi method is used to optimize the robustness of the motor, and the test data is processed through the relation analysis method to obtain the optimal combination of control factors. Finally, the prototype is manufactured for the experiment. Compared with the single‐operating conditions robust optimization results, the robust optimization method improves the robustness of the motor. The cogging torque amplitude is reduced by 39.2%. The torque ripple is 38.4% lower than that before optimization.
Solvothermal synthesis of a new heterometallic Cd–Ba compound based on terephthalic acid: Catalytic property and therapeutic effect on diabetes
Authors: Tu Jia‐Shu , Zhang Shao‐Wen , Ying Hong‐An , Hong Wei‐Wen , Chen Dan 
Published: February 2022

AbstractPresented is a new heterometallic compound, namely [Cd2Ba2(pdc)4(H2O)4(DMA)2]}n·n(H2O) (1, H2pdc = terephthalic acid, DMA is N, N′‐dimethylacetamide), which was created with the solvothermal reaction. The architectural analysis of X‐ray indicated that the 1 reveals a three‐dimensional skeleton according to one‐dimensional infinite chains. After removal of the free along with coordinated solvent molecules, it contains 49.8% solvent‐accessible volume and unsaturated coordination sites. The solvent‐free form of 1 exhibits excellent catalytic effect for the addition reaction between diethylzinc and benzaldehyde. Its therapeutic effect and mechanism exploration on diabetes was conducted in this present research. Firstly, the abundance of intestinal flora in the gut was detected with real time RT‐PCR assay. Besides, the measurement of the levels of sugar was conducted with blood glucose meter in the T2DM animal after compound treatment. The cytotoxicity of the 1 was evaluated with CCK‐8 assay.
Thermal scanning probe lithography using Parylene C as thermal resist
Authors: Jiang Yun , Dodds Kevin , Dunare Camelia , Lomax Peter , Cheung Rebecca 
Published: February 2022

AbstractThermal scanning probe lithography is a direct‐write patterning method that uses a heated scanning probe tip to remove thermal resist. The most widely used thermal resist is polyphthalaldehyde. Another alternative thermal resist, Parylene C is introduced in this letter. It has been found that Parylene C has a wide process latitude as a thermal resist under our experimental conditions. A high resolution of ∼40 nm can be achieved in our optimised process. In addition, patterns in parylene layer can be transferred directly into the substrate with deep reactive ion etching without an additional hard mask, thus simplifying the fabrication process.
Anti‐saturation GPC speed control of induction motor drives
Authors: Khelifi otmane Khelifa 
Published: February 2022

AbstractOne of the most critical issues in the fast and large step change in the speed control of an induction motor is the excessive generated current command, and consequently, if the speed controller does not have output magnitude limiter, this might end up damaging the power electronics converter and the motor itself. This paper is devoted to overcoming the speed controller saturation phenomenon. Firstly, predictive controllers in polynomial form are designed for the speed control loop and for the two inner currents control loops. Then, the outer predictive speed controller is retuned by convex optimization of the Youla parameter considering temporal and frequency constraints, so that the resulting controller assures that the speed response to the reference remains in an imposed template with a minimal current command in transient periods and, in other hand, it keeps the closed loop features obtained by the initial predictive controller. Simulations results show the speed control performance of the proposed control system for various operating conditions of the motor.
Analysis of the public HARPS/ESO spectroscopic archive
Authors: Sreenivas K. R. , Perdelwitz V. , Tal-Or L. , Trifonov T. , Zucker S. , Mazeh T. 
Published: February 2022

Aims. We use the recently published database of radial velocities (RVs) that were derived from fifteen years of HARPS/ESO observations to search for planet candidates.
Methods. For targets with sufficient RV data, we applied an automated algorithm to identify significant periodic signals and fit a Keplerian model for orbital estimates. We also searched the auxiliary data of stellar-activity indices and compared our findings with existing literature, to detect periodic RV signals that have no counterpart in the activity timeseries. The most convincing signals were then manually inspected to designate additional false planet detection, focusing the search on long-period (P > 1 000 days) massive candidates around FGK dwarf stars.
Results. We identified two Jupiter analogs, in orbit around the slightly evolved F8V star HD 103891 and the Solar-like star HD 105779. We used nested sampling to derive their orbital parameters, and found their orbital periods to be 1919 ± 16 days and 2412 ± 54 days, while their minimum masses are 1.44 ± 0.02 MJup and 0.64 ± 0.06 MJup, respectively. While the orbit of HD 103891 b is slightly eccentric (e = 0.31 ± 0.03), that of HD 105779 b is likely circular (e < 0.16).
Conclusions. With minimum astrometric signatures of ~59 and ~42 μas, HD 103891 b and HD 105779 b join the growing sample of planets whose exact masses may soon be derived with Gaia astrometry. This finding also highlights the importance of long-term RV surveys to study planetary occurrence beyond the snow line of Solar-like stars.
Erste Anwendungserfahrung eines neuen, Glukosesensor-unterstützten Pumpensystems mit vorausschauender Insulin-Abschaltung zum Hypoglykämieschutz bei pädiatrischen Patienten in Deutschland
Authors: von dem Berge Thekla , Remus Kerstin , Biester Sarah , Reschke Felix , Datz Nicolin , Danne Thomas , Kordonouri Olga , Biester Torben 
Published: February 2022

Zusammenfassung
Einleitung Die prädiktive Insulinabschaltung ist als System zur Prävention von Hypoglykämien in Deutschland etabliert (Smartguard). Seit 2020 ist in Deutschland ein zweites System verfügbar (Basal-IQ). Unterschiede betreffen eine nicht veränderbare prädiktive Abschaltgrenze von 80 mg/dl (vs. 50–90 mg/dl), eine Abschaltzeit von minimal 5 Minuten (vs. 30 Minuten) sowie die Festlegung der Wiedereinschaltung des Insulin bei einem höheren Wert als zuvor (vs. einem Abstand von 20 mg/dl über der Abschaltgrenze und höherer Prädiktion). Die Systeme wurden in einer Altersgruppe, die besonders von Unterzuckerungen bedroht ist, verglichen.
Methodik Pädiatrische Patienten (Alter 6–13 Jahre), mit Pumpen- und Sensorerfahrung (kein AID) wurde die Erprobung von Basal-IQ für eine Dauer von 3 Monaten angeboten. Betrachtet wurden die CGM-Parameter Zeit unter Zielbereich (TBR < 70mg/dl), im Zielbereich (TIR 70–180 mg/dl), glykämische Variabilität (Varianzkoeffizient CV%) und HbA1c. Patienten-bezogene Outcomes (PROʼs) wurden mit dem Diabskids-Elternfragebogen und einem Gerätefragebogen erfasst.
Ergebnisse Neun Teilnehmer (alle männlich, Mittelwerte: 9.7 Jahre, Diabetesdauer 6.1 Jahre, HbA1c 6.8%, Time in Range (TIR) 61.9%, Time below Range (TBR) 4.5%, mittlere Glukose (MW) 164 mg/dl, (CV) 40) wurden gefunden. Nach 3 Monaten konnten Verbesserungen der glykämischen Parameter beobachtet werden (HbA1c 6.5%, TIR 69.2%, TBR 2.8%, MW 159, CV 40; Kontrollen HbA1c 7.2%, TIR 64.9%, TBR 4.3%, MW 158, CV 39), die sich von einer zeitgleich mit Smartguard behandelten Kindern nicht unterschieden. Die Erfassung der PROʼs zeigte einen Rückgang der Diabetes- und Therapiebelastung, sowie eine Zufriedenheit mit dem System.
Diskussion Das neue System mit prädiktiver Abschaltung zeigte nach 3 Monaten eine Verbesserung der glykämischen Parameter und PROʼs. Ein statistischer Vergleich vorher/nachher ist aufgrund der geringen Patientenzahl nicht erfolgt, aber die Daten zeigen zumindest die Nichtunterlegenheit gegenüber dem Baseline-Zeitpunkt und den Daten, die aus einer Gruppe von Patienten mit kontinuierlicher Systemnutzung stammen. Somit stehen in Deutschland aktuell zwei verschiedene effiziente Systeme mit prädiktiver Insulinabschaltung für Kinder und Jugendliche mit Diabetes zur Verfügung, so dass diese nach fundierter Beratung auswählen können.
Solide pseudopapilläre Pankreasneoplasie bei Kindern und
Jugendlichen
Authors: Madadi-Sanjani Omid , Zöller Christoph , Beilken Andreas , Pfister Eva-Doreen , Sander Björn , Ure Benno , Dingemann Jens 
Published: February 2022

Zusammenfassung
Hintergrund Pankreastumore im Kindes- und Jugendalter sind seltene
Entitäten, die lange Zeit asymptomatisch verlaufen und häufig
als Zufallsbefund bei bildgebenden Untersuchungen aus anderen Gründen
oder durch abdominelle Schmerzen auffallen. Solide pseudopapilläre
Pankreasneoplasien (SPN) sind seltene Vertreter dieser Gruppe. Die Therapie der
SPN besteht in der primären R0 Resektion. Wir stellen vier Fälle
von SPN vor und diskutieren das individualisierte diagnostische und
therapeutische Vorgehen.
Methode Retrospektive Fallstudie an Hand von vier Patientinnen mit SPNs,
die in den Jahren 2015–2020 behandelt wurden.
Ergebnisse Bei vier weiblichen Patienten (11–17 Jahre) wurde eine
SPN diagnostiziert. Drei SPN waren im Pankreaskopf lokalisiert. Die
histologische Sicherung erfolgte durch eine endosonographisch-, CT-gesteuerte
oder offene Tumorbiopsie. Eine R0-Resektion wurde mittels pyloruserhaltender,
partieller Duodenopankreatektomie nach Traverso-Longmire erzielt. In einem Fall
war der Tumor im Pankreasschwanz lokalisiert. Es bestand zusätzlich eine
Tumoradhärenz an den Milzgefäßen. Eine CT-gesteuerte
Biopsie bestätigte den Verdacht auf eine SPN und es erfolgte eine
Pankreasschwanzresektion mit Splenektomie. Im Follow-up (6–72 Monate,
Median: 28,5 Monate) ergaben sich bei keinem Patienten Hinweise auf
Tumorrezidive, Metastasen oder einen pankreopriven Diabetes.
Schlussfolgerung Zur Therapieplanung ist eine präoperative
histologische Diagnosesicherung von SPN notwendig. Aufgrund der
individualisierten diagnostischen und therapeutischen Konzepte, ist eine
Versorgung in Zentren mit spezialisierter Kinderchirurgie, Kinderonkologie,
Kinder-Gastroenterologie, Kinderradiologie und Pathologie essentiell.
Outcome of Cancer-Associated Venous Thromboembolism Is More Favorable among Patients with Hematologic Malignancies than in Those with Solid Tumors
Authors: Lecumberri Ramón , Ruiz-Artacho Pedro , Tzoran Inna , Brenner Benjamin , Farge-Bancel Dominique , Ay Cihan , Rosa Vladimir , Francisco Iria , Hernández-Blasco Luis Manuel , Trujillo-Santos Javier , Monreal Manuel ,   the RIETE Investigators
Published: February 2022

Abstract
Background The natural history of patients with hematologic cancer and venous thromboembolism (VTE) has not been consistently evaluated. We aimed to compare the rates of symptomatic recurrent VTE, major bleeding, or death during anticoagulant therapy in patients with VTE associated with hematologic versus solid cancers.
Methods Consecutive patients with active cancer recruited in RIETE were evaluated. Their baseline characteristics, treatments, and outcomes during the course of anticoagulation were compared. Univariate and multivariate competing-risk analyses were performed.
Results As of December 2020, 16,694 patients with cancer and VTE were recruited. Of these, 1,062 (6.4%) had hematologic cancers. Hematologic patients were less likely to initially present with pulmonary embolism (46 vs. 55%) and more likely with upper extremity deep vein thrombosis (25 vs. 18%). They also were more likely to have severe thrombocytopenia at baseline (5.6 vs. 0.7%) or to receive chemotherapy (67 vs. 41%). During the course of anticoagulation (median, 150 vs. 127 days), 1,071 patients (6.4%) developed VTE recurrences, 806 (4.8%) suffered major bleeding, and 4,136 (24.8%) died. Patients with hematologic cancers had lower rates of recurrent VTE (rate ratio [RR]: 0.73; 95% confidence interval [CI]: 0.56–0.95), major bleeding (RR: 0.72; 95% CI: 0.53–0.98), or all-cause death (RR: 0.49; 95% CI: 0.41–0.57) than those with solid cancers. Patients with multiple myeloma showed the best outcomes.
Conclusion Patients with hematologic cancers, particularly multiple myeloma, and VTE had better outcomes than those with solid cancers. These findings are relevant for the interpretation of previous clinical trials and the design of future studies.
The Lesson Learned from the New c.2547-1G > T Mutation Combined with p.R854Q: When a Type 2N Mutation Reveals a Quantitative von Willebrand Factor Defect
Authors: Casonato Alessandra , Cozzi Maria Rita , Ferrari Silvia , Rubin Beatrice , Gianesello Lisa , De Marco Luigi , Daidone Viviana 
Published: February 2022

AbstractType 2N is a rare von Willebrand disease (VWD) variant involving an impairment in the factor VIII (FVIII) carrier function of von Willebrand factor (VWF). It has a phenotype that mimics hemophilia A, and FVIII binding to VWF (VWF:FVIIIB) is tested to differentiate between the two disorders. Type 2N VWF defects may also be associated with quantitative VWF mutations (type 2N/type 1), further complicating the identification of cases. We report on a new quantitative VWF mutation (c.2547–1G > T) revealed by a p.R854Q type 2N mutation acting as homozygous despite being carried as a heterozygous defect. The proband had near-normal VWF levels (initially ruling out a defective VWF synthesis) and slightly reduced FVIII levels, while a VWF:FVIIIB test showed significantly reduced binding. Routine tests on type 2N homozygotes or heterozygotes combined with quantitative VWF defects in our cohort showed reduced FVIII levels in both groups, but it was only in the former that the FVIII/VWF antigen (VWF:Ag) ratio was always significantly reduced. The two tests are therefore not enough to identify all forms of type 2N VWD. While relatives of type 2N homozygotes usually have normal FVIII levels and FVIII/VWF:Ag ratios, relatives of type 2N/type 1 may have high FVIII/VWF:Ag ratios, but their VWF:FVIIIB and/or VWF:FVIIIB/VWF:Ag ratios are always low. Measuring FVIII and VWF levels may therefore suggest type 2N VWD in patients carrying type 2N mutations alone, but not in type 2N combined with quantitative VWF defects. The VWF:FVIIIB test should consequently be included when exploring VWF function, whatever VWD patient's phenotype.
Mongolian Gerbils as a Model for the Study of Cholesteatoma: Otoendoscopic as a Diagnostic Tool
Authors: Bauer Jefferson André , Huve Felipe da Costa , Oliveira Francine Hehn de , Silva Maurício Noschang Lopes da , Sperling Neil , Costa Sady Selaimen da 
Published: February 2022

Abstract
Introduction Cholesteatoma is a disease with significant clinical impact but is incompletely understood. The challenge of performing studies with long-term follow-up in humans is a factor that has restricted the advance of knowledge in this field. Thus, the use of animal models is highly pertinent, and the Mongolian gerbil model has emerged as one of the most useful.
Objective The present study aims to evaluate, through serial otoendoscopies, the development and characteristics of pars flaccida retraction pocket and cholesteatoma in Mongolian gerbils after obliteration of the eustachian tube and compare it with the control group.
Methods Forty Mongolian gerbils were divided into two groups of 20 animals each. In the intervention group, the animals were followed with serial otoendoscopies after eustachian tube obliteration. In the control group, the animals were only followed through serial otoendoscopies.
Results At the end of the 16-week follow-up, cholesteatoma was present in 13 of 38 (34.2%) ears in the intervention group, and in 7 of 34 (20.6%) in the control group (p = 0.197). When we considered cholesteatoma and its potential precursor, pars flaccida retraction pocket, in a combined way, we verified it in 23 of 38 (60.8%) in the intervention group and in 11 of 34 (32.3%) in the control group (p = 0.016).
Conclusions Over the 16 weeks of follow-up, serial otoendoscopies enabled us to evaluate the formation and development of pars flaccida retraction pockets and cholesteatomas in Mongolian gerbils and proved to be an excellent diagnostic tool.
Selective Neck Dissection for Node-Positive Oral Cavity Squamous Cell Carcinoma: A Retrospective Cohort Study
Authors: Hashmi Syed Salman , Abbas Akbar , Bukhari Amna , Saeed Javeria , Shafqat Ali , Siddique Atif Hafeez , Buksh Ahmed Raheem , Murtaza Ghulam 
Published: February 2022

Abstract
Introduction Selective neck dissection in clinically node-negative neck is considered the standard of care for oral squamous cell carcinomas (SCCs). Controversy still prevails in node-positive disease regarding the extent of neck dissection. In our part of the world, comprehensive neck dissection is mostly considered to be the minimal optimal treatment for palpable neck disease.
Objective To compare regional control and disease-specific survival between clinically node-positive and node-negative patients undergoing selective neck dissection for oral SCC.
Methods This was a retrospective cohort study conducted in the department of ENT, Head and Neck surgery at a tertiary care hospital. All patients with biopsy-proven oral and lip SCC, with or without nodal disease, who underwent selective neck dissection between April 2006 and July 2015 were included in the study.
Results During the study period, 111 patients with oral SCC underwent selective neck dissection, of whom 71 (62%) were clinically node-negative and 40 (38%) patients had clinically positive nodes in the neck. The mean follow-up was 16.62 months (standard deviation [SD]: 17.03). The overall regional control rates were 95 versus 96% for clinical negative versus positive nodes, respectively (p = 0.589). The disease-specific survival was 84.5% in the node negative group versus 82.5% in the node-positive group (p = 0.703).
Conclusion Selective neck dissection in node-positive neck oral SCC has similar regional control rates when compared with node-negative neck SCC. The difference in disease-specific survival between the two groups is also not significant.
Safety and Effectiveness of Prolonged Magnesium Sulfate (MgSO4) Infusion for Asthma Exacerbation in Children
Authors: Awlad Thani Saif Sulaiman , Alkhan Atheer Ahmed , Al-Farsi Muzna Yahya , Al Kamzari Ahmed Mohammed 
Published: February 2022

AbstractThe objective of this study was to assess the safety and describe treatment details of prolonged magnesium sulfate (MgSO4) infusion for children with asthma exacerbation. A retrospective cross-sectional study included children under 13 years of age who were admitted with asthma exacerbation and received at least 24 hours of MgSO4 infusion. One hundred children were included. No patients developed serious adverse events. The mean infusion duration was 74.2 hours. Eighty-nine percent recovered with no other bronchodilator infusions, and 94% did not require respiratory support escalation. Prolonged MgSO4 infusion is safe at a maximum dose of 30 mg/kg/h and may be beneficial for children with asthma exacerbation.
Evaluation of Recurrence and Hearing Outcome for Inactive Squamosal Disease after Cartilage Strengthening Tympanoplasty
Authors: Gupta Priyanshi , Rawat Digvijay Singh , Aseri Yogesh , Verma P. C. , Singh B. K. 
Published: February 2022

AbstractIntroduction Inactive squamosal disease is unique for having a conflicting treatment protocol, with an age-old debate between early surgical intervention or keeping patients in a long-term follow-up. The shifting paradigm is early intervention to prevent further progress into active disease and improve hearing outcome in its nascent stage.Objective To evaluate recurrence and hearing outcome in cases of inactive squamosal disease after cartilage strengthening tympanoplasty.Methods The study was conducted on 50 patients with inactive squamosal disease. Detailed examination was done to grade the retraction. All patients underwent autologous conchal cartilage tympanomastoidectomy with temporalis fascia grafting. Recurrence and hearing evaluations were done by pure tone audiogram at regular intervals for one year.Results Hearing loss was the most common presenting symptom. Isolated pars tensa retractions were more common (54%) than pars flaccida (12%), or those involving both (34%). Ossicular status was normal in only 14% of the cases, and the most common ossicular damage was to the lenticular process of the incus (52%). Three of the patients (6%) had residual perforation at the 3rd month of follow-up. Subjective improvement in hearing was reported by 42% patients. Hearing improvement greater than 10 dB was found in 24 patients (48%). Air–bone gap reduced from 25.16 ± 8.15 dB preoperatively to 12.90 ± 6.20 at 1 year of follow-up. Recurrence was seen in three patients (6%).Conclusion Early intervention by cartilage strengthening of weakened tympanic membrane and ossicular reconstruction not only offers better hearing results, but also prevents progress to active disease.