bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of cutting power in tool condition monitoring and wear prediction based on Gaussian process regression under variable cutting parameters
Authors: Qiang Biyao , Shi Kaining , Liu Ning , Zhao Pan , Ren Junxue 
Published: June 2022

Abstract
Tool wear is inevitable in actual manufacturing, especially in extreme processing conditions for milling difficult-to-cut materials. With the degradation of cutting performance, the undesirable tool status could trigger instability in machining process that causes negative effect on machined surface and dimension accuracy of the precision components. Therefore, tool condition monitoring for machining process is imperative. With distinctive characteristics on easy acquisition and non-interference in machining process, the power consumption of machine tool has been proved to be a reliable indicator for reflecting the changes of cutting process in industry. Thus, the present study proposes a novel method for monitoring tool condition using net cutting power consumption. The result indicates that the developed approach performs better than traditional approach which uses original total power to predict tool wear. This can be attributed to the changes of net cutting power consumption is more relevant with tool wear evolution. Furthermore, predicting tool wear under variable cutting parameters is achieved using Gaussian process regression, because it has good generalization performance and also explains the uncertainty of prediction results in the form of probability. This study reveals that low-cost sensor like power meter, can be used as an important supplement to monitor tool condition in the industry, and also provides a research basis for predicting tool wear under different cutting conditions.
Patient perspectives on non-response to psychotherapy for borderline personality disorder: A qualitative study.
Authors: Woodbridge Jane , Townsend Michelle L. , Reis Samantha L. , Grenyer Brin F. S. 
Published: June 2022

Abstract
Background: Despite increasing evidence for the effectiveness of psychotherapy for Borderline Personality Disorder (BPD), estimates show that approximately half of those in treatment do not clinically improve or reach reliable change criteria. There are limited qualitative descriptions of treatment factors associated with non-response from the perspectives of those struggling to improve. Method: Eighteen people (72.2% female, mean age 29.4 (SD = 8)) with experience of receiving psychotherapeutic treatment for BPD were interviewed to obtain their perspectives on helpful and hindering factors in treatment. The data in this qualitative study was analysed thematically. Results: Four domains were created from the insights patients shared on helpful and hindering factors. The focus of Domain 1 was that therapy cannot be effective until two factors are in place. First, the patient needs sufficient safety and stability in their environment in order to face the challenges of therapy. Second, they need to be able to access therapy. Domain 2 described factors the patients themselves contribute. The themes in this domain were described as phases that need to be progressed through before therapy can be effective. These phases were ceasing denial that help is warranted and deserved, taking responsibility for behaviours that contribute to unwellness, and committing to the hard work that is required for change. Domain 3 described how the lack of a safe alliance and ruptures in the safety of the relationship with the therapist can contribute to non-response. Domain 4 focused on specific therapist strategies. The first theme in this domain was prioritising the safety of the therapy relationship. The second theme was giving a clear diagnosis and taking a collaborative approach in sessions. The final theme described the importance of focusing on practical goals with the patient to create tangible life changes.Conclusion: This study found that non-response is complex and multifaceted. First, it is clear that systems need to be in place to support access to adequate care and foster life stability. Second, considerable effort may be needed at the engagement phase of therapy to clarify expectations. Third, attention to specific interpersonal challenges between patients and therapists is an important focus. Finally, structured work to improve relationships and vocational outcomes is indicated.
Fantastic Perspectives and Where to Find Them: Involving Patients and Citizens in Digital Health Research
Authors: Osmanlliu Esli , Paquette Jesseca , Grenier Annie-Danielle , Lewis Paul , Bouthillier Marie-Êve , Bédard Sylvain , Pomey Marie-Pascale 
Published: June 2022

Abstract
Background: Digital contact tracing and exposure notification apps have quickly emerged as a potential solution to achieve timely and effective contact tracing for the SARS-CoV-2 virus. However, their actual uptake remains limited, and citizens, including patients, are rarely consulted and included in the design and implementation process. However, their contribution could be determinant in the success of such apps. The DIGICIT (DIGITal CITizenship) project relied on patient and citizen partnership in research to assess public perspectives on these apps.Objectives: This article has three objectives: (1) describe the methodological process to co-construct a questionnaire and interpret the survey results with patients and citizens, (2) assess their experiences regarding this methodology, and (3) propose best practices for their involvement in digital health research.Methods: The DIGICIT project was developed in four steps: (1) creation of the advisory committee composed of patients and citizens, (2) co-construction of a questionnaire, (3) interpretation of survey results, and (4) assessment of the experience of committee participants.Results: Of the 25 applications received, 12 people met our diversity criteria and were included in the advisory committee. 84 survey questions were generated in the first co-construction meeting and were cut down to 36 in the final version. Participants made more than 20 recommendations when interpreting survey results and suggested carrying out focus groups with marginalized populations to increase representativity. They appreciated their inclusion early in the research process, being listened to and respected, the collective intelligence, and the method used for integrating their suggestions. They suggested that the study objectives and roles be better defined, that more time in the brainstorming sessions be allowed, and that discussion outside of meetings be encouraged. Conclusion: Having patients and citizens actively participating in this research constitutes the main methodological strength. They helped reorient the project by adding focus groups to the research protocol. Clear communication of the project objectives, good organization in meetings, and continuous evaluation from participants allow best practices to be achieved for patients' and citizens' involvement in digital health research. Co-construction in research generates critical study design ideas through collective intelligence. This methodology can be used in various clinical contexts and different healthcare settings.
Timing of Intubation and ICU Mortality in COVID-19 Patients: A Preplanned Retrospective Analysis of 4198 Critically Ill Patients
Authors: Manrique Sara , Claverias Laura , Magret Mónica , Masclans Joan Ramon , Bodi María , Trefler Sandra , Canadell Laura , Diaz Emili , Sole-Violan Jordi , Bisbal-Andrés Elena , Gonzalez Ruth , Albaya Antonio , Vallverdu Monserrat , Ballesteros Juan Carlos , Socias Lorenzo , Gordo Federico , Sancho Susana , Loeches Ignacio Martín , Rodriguez Alejandro 
Published: June 2022

Abstract
Background Optimal time to intubate patients with SARS-CoV-2 pneumonia is controversial. Whereas some authors recommend trying noninvasive respiratory support before intubate, others argue that delaying intubation can cause patient-self-induced lung injury and worsen the prognosis. We hypothesized that delayed intubation would increase the risk mortality in COVID-19 patients.Methods This preplanned retrospective observational study used prospectively collected data from adult patients with COVID-19 and respiratory failure admitted to 73 intensive care units between February 2020 and March 2021. Patients with limitations on life support and those with missing data were excluded. We collected demographic, laboratory, clinical variables and outcomes. Intubation was classified as 1) Very early: before or at ICU admission; 2) Early: < 24 hours after ICU admission; or 3) Late: ≥24 hours after ICU admission. We compared the early group versus those intubated late, using chi-square tests for categorical variables and the Mann-Whitney U for continuous variables. To assess the relationship between early versus late intubation and mortality, we used multivariable binary logistic regression. Statistical significance was set at p<0.05.Results We included 4198 patients [median age, 63 (54‒71) years; 70.8% male; median SOFA score, 4 (3‒7); median APACHE score, 13 (10‒18)], and median PaO2/FiO2, 131 (100‒190)]; intubation was very early in 2024 (48.2%) patients, early in 928 (22.1%), and late in 441 (10.5%). ICU mortality was 30.2% and median ICU stay was 14 (7‒28) days. Although patients in the late group were younger [62 vs. 64, respectively, p<0.05] and had less severe disease [APACHE II (13 vs. 14, respectively, p<0.05) and SOFA (3 vs. 4, respectively, p<0.05) scores], and higher PaO2/FiO2 at admission (116 vs. 100, respectively, p<0.05), mortality was higher in the late group than in the early group (36.9% vs. 31.6%, p<0.05). Late intubation was independently associated with mortality (OR1.83; 95%CI 1.35‒2.47).Conclusions Delaying intubation beyond the first 24 hours of admission in patients with COVID-19 pneumonia increases the risk of mortality.Trial registration: clinical-Trial.gov (NCT 04948242)
The roles of antitoxic of Enzymes in rice plant, grown on acid sulfate soils, Mekong Delta
Authors: Huy Ba Le , Xuan Hoan Nguyen , Van Nam Thi , Tan Phong Nguyen 
Published: June 2022

Abstract
Assessing the resistance, determining the nature of the resistance of the rice plant through the activity of three enzymes in rice: Catalase, Peroxydase and Phosphatase in the leaves of rice plants (the most active leaves of rice) rice plants) [2]. In addition, consider the role of Phosphatase in the fluctuations and the ability to accumulate P2O5 in soil and plants to see its role in rice's poison resistance in acid sulphate soil [4]. In other hand, Results shows that- High concentrations of toxins in the soil environment strongly inhibited the activity of Phosphatase enzymes in the roots, in the indicator leaves, and especially for rice, especially for plants that are less resistant to poisoning. But, Phosphatase enzyme in leaves has the effect on the providing energy for the plants to recover from poisoning. The activity of this enzyme is inversely correlated with the content of Al3+ in soil and Al3+ in plants. This proves that the antagonism between enzymes and toxins is evident, especially with Al3+ toxins. In other side, has highly toxic in the acid sulphate soil environment inhibits enzyme activity Peroxydase in rice roots. Under these conditions, peroxydase in the root plays a small role in helping the plant recover.We have sufficient basis to confirm that the enzyme Peroxydase in leaves plays an important role, against the harmful effects of toxins. When the toxin in the soil, in plants increased activity of this enzyme also increased higher than the control variant. Especially, when the toxicity increases, the Peroxydase enzyme in the rice leaves will also increase to resistant to toxicity ( + 280% (compared to the control); while the toxicty- non -resistant variety plants did not increase (compared to the control). When the toxicity decreased, Peroxydase activity in toxic-resistant plants was also higher than toxic non-resistant: This increased at + 643% for toxic-resistant rice compared to the control. While, in the weekly- resistant toxic- variety only increased + 314% (compared to the control).
Teosinte high protein 9 enhances the seed protein content and nitrogen utilization efficiency in maize
Authors: Wu Yongrui , Huang Yongcai , Wang Haihai , Zhu Yidong , Huang Xing , Li Shuai , Wu Xingguo , Zhao Yao , Bao Zhigui , Qin Li , Jin Yongbo , Cui Yahui , Ma Guangjin , Xiao Qiao , Wang Qiong , Wang Jiechen , Yang Xuerong , Liu Hongjun , Lu Xiaoduo , Larkins Brian , Wang Wenqin 
Published: June 2022

Abstract
The maize (Zea mays ssp. mays) wild ancestor, teosinte, has three times the seed protein content of most modern inbreds and hybrids, but the mechanisms responsible for this trait are unknown. We created a contiguous haplotype DNA sequence of a teosinte, Zea mays ssp. Parviglumis, with Trio-Binning, and map-based cloned a major high-protein QTL, teosinte high protein 9 (Thp9) on chromosome 9. Thp9 encodes an asparagine synthetase 4 that is highly expressed in teosinte, but not in the B73 inbred, where a deletion in the 10th intron of Thp9-B73 causes incorrect splicing of Thp9-B73 transcripts. Transgenic expression of Thp9-teosinte in B73 significantly increased seed protein content. Introgression of Thp9-teosinte into modern maize inbreds and hybrids greatly enhanced free amino acid accumulation, especially asparagine, throughout the plant, increasing seed protein content without affecting yield. Thp9-teosinte appears to increase nitrogen utilization efficiency, important for promoting a high yield under low nitrogen conditions.
Relation of fish size with that of its otolith of Pama croaker, Otolithoides pama (Hamilton, 1822) from Narmada estuary, India
Authors: Bhakta Dibakar , Kamble Suhas Prakash , Meetei Wakamban Anand , Solanki Jayesh Kumar , Sah Rajesh Kumar , Solanki Sonia , Das Basanta K. 
Published: June 2022

Abstract
The relation of fish size with that of its otolith of pama croaker, Otolithoides pama (Hamilton, 1822) was established. Fish specimens were collected from the bagnet catch from Narmada estuary, India for a period of 8 months (November 2018 to June 2019). To understand the relationship between fish and otolith size, the sagittal otoliths were extricated, cleaned, measured, and photographed. The Otolith length (OL), Otolith breadth (OB), and Otolith weights (OW) were measured from each specimen to the nearest size of 0.01 mm and weight of 0.01 g. The observed length and weight of the fish were in the range of 85 to 288 mm (175.79±33.13 mm) and 3.0 to 186.56 g (43.68±27.67 g), respectively. The recorded otolith length, breadth, and weight were in the range of 2.65 to 12.54 mm (7.20±1.77 mm), 2.01-10.48 mm (5.95±1.33 mm), and 0.02 g to 0.75 g (0.23±0.11 g), respectively. The data fitted well to the power model for the OL, OB, OW, and fish length and weight. High values of the coefficient of determination (R2) were recorded between fish length and otolith length (R2 = 0.978), fish length and otolith weight (R2 = 0.931), fish length and otolith breadth (R2 = 0.985), fish weight and otolith length (R2 = 0.942), fish weight and otolith weight (R2 = 0.922), and fish weight and otolith breadth (R2 = 0.962). The study also depicted a high correlation of otolith dimensions with the size of the fish.
A Wide-Range and Fast-Locking All-Digital DLL with One-Cycle Dynamic Synchronizing for In-Cell Touched LC Display
Authors: Hong Zhen-Jie , Lo Yu-Lung , Shen Kuan-Yu , Chen Guan-Yu , Li Wei-Ju 
Published: June 2022

Abstract
This paper proposes wide-range and fast locking all-digital delay-locked loop (WRADDLL) circuit with one cycle dynamic synchronizing. The WRADDLL not only synchronizes the input and output clocks in five clock cycles but maintains one cycle dynamic locking. The WRADDLL reduces the clock skew between the input and output clocks with three innovative techniques. First, by improving the mirror control circuit, the WRADDLL operates correctly with a flexible duty cycle clock signal. Second, the WRADDLL works precisely and ignores the effect of output load changes by moving the measurement delay line beyond the output driver. Besides, it can achieve one-cycle dynamic locking. Finally, the WRADDLL utilizes the band selector to achieve wide-range operation. After fine tuning, the maximum static phase error is less than 3% of clock cycle. The chip is fabricated by 90 nm standard CMOS process. Its operating frequency range is from 200 MHz to 2 GHz. The power consumption and RMS jitter are 3.24 mW and 1.49 ps at 2 GHz, respectively. The active area of this chip is 0.011 mm2.
Clinical features and surgical management of tuberculous arthritis of the sacroiliac joint: a retrospective analysis of 33 patients
Authors: Tian Qi , Na Linhao , Cao Shicong , Tian Zheng , Guo Zheng 
Published: June 2022

Abstract
Background: Tuberculous sacroiliac joints are relatively rare. Due to the insidious onset and easy misdiagnosis, they often develop into later severe joint destruction without effective treatment in the early stage. There are few existing studies on tuberculous sacroiliitis. In our study, we reviewed 3 different types of tuberculous sacroiliitis via anterior and posterior approaches to determine the efficacy and safety of this surgical approach by describing clinical presentation, imaging, and surgical treatment.Methods: We reviewed 33 patients with 3 different types of severe tuberculous sacroiliitis, of which 16 patients with anterior iliac abscess underwent anterior debridement and bone graft fusion. 17 patients underwent posterior debridement and bone graft fusion. Among them, 5 patients with lumbar tuberculosis underwent lesion debridement through fenestration, joint fusion, and interbody fusion and internal fixation. One patient with anterior paravertebral abscess underwent lesion debridement through posterior fenestration and bone graft fusion in the first operation, and the anterior abscess was removed and intervertebral fusion in the second operation. The mean postoperative follow-up was 16.9 months (12-25 months).Erythrocyte sedimentation rate (ESR), visual analogue scale (VAS) and the Oswestry Disability Index (ODI) were used to judge the postoperative condition and functional recovery. X-ray and CT scan were used to evaluate the fusion of sacroiliac joints.Results: All patients' hip, back and lower back pain symptoms were significantly relieved after surgical treatment. At 3 months after operation, the VAS and ODI scores of all patients decreased significantly. At 12 months after operation, the patients had no obvious pain or only slight discomfort during activities, and the lower limb function basically recovered, which could meet the needs of daily work and life.All cases had sacroiliac joint fusion within 12 months after operation.Conclusion: Tuberculous sacroiliitis is easy to be misdiagnosed due to its insidious onset.Therefore, patients with hip, groin and lower back pain must be carefully checked to avoid misdiagnosis.Surgical treatment should be performed as soon as possible under the adjuvant chemotherapy of anti-tuberculosis drugs. According to the different characteristics of sacroiliac joint tuberculosis, appropriate surgical operations should be adopted according to our classification criteria.
Circular RNA circXPO1 promotes multiple myeloma progression via sponging miR-495 3p and upregulating of DDIT4
Authors: Li Fangmei , Liu Jing , Miao Jiyu , Hong Fei , Lv Yang , Wu Dong , Shen Ying , Liu Rui , Zhang Ru , Jia Yachun , Zhai Meng , Li Xinye , He Aili , Wang Jianli 
Published: June 2022

Abstract
Background:Multiple myeloma (MM) is a hematologic cancer featured by malignant proliferation of plasma cells. The therapeutic strategies for MM patients include chemotherapy, immune therapy and targeted therapy. However, MM is still an incurable malignancy. To extend therapeutic arsenal for MM, it is important to uncover the molecular mechanism and cellular machinery behind the vicious progression of MM. Circular RNAs (circRNAs) are versatile regulators that affect aggressive behaviors of many cancers. However, the roles and underlying mechanisms of circRNAs in MM are not well elucidated. CircXPO1 (also referred to as hsa_circRNA_102735) is a newly discovered circRNA that is upregulated in multiple myeloma (MM) based on microarray analysis. This study aimed to investigate roles of circXPO1 in MM. Methods: We investigated the expression pattern of circRNAs in primary Multiple myeloma samples using the circRNA microarray. The characteristics, potential diagnostic value, and prognostic significance of circXPO1 were evaluated among 54 newly diagnosed MM patients by analyzing the expression of circXPO1 in different disease stages. Knockdown and overexpression were used to evaluate the effects of circXPO1 on myeloma malignancy in vitro and in vivo. Biotin RNA pulldown assay and dual-luciferase reporter assay were implemented to verify the interaction between circXPO1 and miR-495-3p. Dual-luciferase reporter assay was used to prove the combination miR-495-3p and DDIT4.Results：CircXPO1 was highly expressed in bone marrow (BM)-derived plasma cells of MM patients and MM cell lines than that in iron deficiency anemia (IDA) controls. CircXPO1 promoted the proliferation, cell cycle, and impeded the apoptosis of MM cells. MiR-495-3p was a direct target of circXPO1 in MM cells, and circXPO1 promote myeloma progression via sponging miR-495-3p. DDIT4 could directly bind to miR-495-3p in MM cells and miR-495-3p exerted an anti-tumor role through targeting DDIT4.Conclusion：CircXPO1, acting as an oncogene, could promote the proliferation, cell cycle, and restrain the apoptosis of MM cells through regulating miR-495-3p and DDIT4, which provides novel insights into MM therapy.