bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of serum biomarkers in dogs with malignant melanoma receiving anti-PD-L1 therapy and potential of COX-2 inhibition for combination therapy
Authors: Maekawa Naoya , Konnai Satoru , Asano Yumie , Sajiki Yamato , Deguchi Tatsuya , Okagawa Tomohiro , Watari Kei , Takeuchi Hiroto , Takagi Satoshi , Hosoya Kenji , Kim Sangho , Ohta Hiroshi , Kato Yukinari , Suzuki Yasuhiko , Murata Shiro , Ohashi Kazuhiko 
Published: June 2022

AbstractImmune checkpoint inhibitors (ICIs) such as anti-PD-L1 antibodies are widely used to treat human cancers, and growing evidence suggests that ICIs are promising treatments for canine malignancies. However, only some canine oral malignant melanoma (OMM) cases respond to ICIs. To explore biomarkers predictive of survival in dogs with pulmonary metastatic OMM receiving the anti-PD-L1 antibody c4G12 (n = 27), serum concentrations of prostaglandin E2 (PGE2), cytokines, chemokines, and growth factors were measured prior to treatment initiation. Among 12 factors tested, PGE2, interleukin (IL)-12p40, IL-8, monocyte chemotactic protein-1 (MCP-1), and stem cell factor (SCF) were higher in OMM dogs compared to healthy dogs (n = 8). Further, lower baseline serum PGE2, MCP-1, and vascular endothelial growth factor (VEGF)-A concentrations as well as higher IL-2, IL-12, and SCF concentrations predicted prolonged overall survival. These observations suggest that PGE2 confers resistance against anti-PD-L1 therapy through immunosuppression and thus is a candidate target for combination therapy. Indeed, PGE2 suppressed IL-2 and interferon (IFN)-γ production by stimulated canine peripheral blood mononuclear cells (PBMCs), while inhibition of PGE2 biosynthesis using the COX-2 inhibitor meloxicam in combination with c4G12 enhanced Th1 cytokine production by PBMCs. Thus, serum PGE2 may be predictive of c4G12 treatment response, and concomitant use of COX-2 inhibitors may enhance ICI antitumor efficacy.
Occurrence and seasonal disparity of emerging endocrine disrupting chemicals in a drinking water supply system and associated health risk
Authors: Kumawat Manoj , Sharma Poonam , Pal Namrata , James Meenu Mariya , Verma Vinod , Tiwari Rajnarayan R. , Shubham Swasti , Sarma Devojit Kumar , Kumar Manoj 
Published: June 2022

AbstractContamination of drinking water with endocrine-disrupting chemicals (EDCs) raises concerns over the security and long-term sustainability of clean water supplies as well as human exposure via daily water intake. In this study, the seasonal disparity and occurrence of six phthalates and bisphenol-A in the drinking water supply system and associated health-risk were examined. The detection frequencies of the ∑6PAEs ranged from 24 to 100% in the winter whereas; in summer it is below the detection limit up to 100%. DEHP was the most prevalent phthalate congener ranging from 1.14 to 8351.85 µg/L (winter) and 0.552 to 410.29 µg/L (summer) surpassing the permissible limit. However, BPA concentrations were found under the permissible limit. The results suggested that PAEs concentration displayed significant seasonal variations with the highest in winter and the lowest in summer. The exposure to PAEs and BPA from drinking water was assessed, indicating a possible health risk to humans with a hazard quotient (HQ) > 1 for DEHP only. The findings necessitate an immediate scrutiny of these EDCs in drinking water supply system and are critical for implementing effective technologies at the WTP scale to ensure the quality and safety of drinking water to ascertain human and environmental health.
Stress concentration-relocating interposer in electronic textile packaging using thermoplastic elastic polyurethane film with via holes for bearing textile stretch
Authors: Takamatsu Seiichi , Sato Suguru , Itoh Toshihiro 
Published: June 2022

AbstractElectronic textile (e-textile) devices require mechanically reliable packaging that can bear up to 30% stretch induced by textile crimp stretch, because the boundary between the rigid electronic components and the soft fabric circuit in the e-textile is prone to rupture due to mismatch of their mechanical properties. Here, we describe a thin stress-concentration-relocating interposer that can sustain a textile stretch of up to 36%, which is greater than the 16% stretch of conventional packaging. The stress-concentration-relocating interposer consists of thin soft thermoplastic polyurethane film with soft via holes and is inserted between the electronic components and fabric circuit in order to move the area of stress concentration from the wiring area of the fabric circuit to the film. A finite element method (FEM) simulation showed that when the fabric is stretched by 30%, the boundary between the electrical components and the insulation layer is subjected to 90% strain and 2.5 MPa stress, whereas, at 30% strain, the boundary between the devices and the wiring is subjected to only 1.5 MPa stress, indicating that the concentration of stress in the wiring is reduced. Furthermore, it is shown that an optimal interposer structure that can bear a 30% stretch needs insulating polyurethane film in excess of 100 μm thick. Our thin soft interposer structure will enable LEDs and MEMS sensors to withstand stretching in several types of fabric.
Higher neutrophil–lymphocyte ratio is associated with depressive symptoms in Japanese general male population
Authors: Kinoshita Hirotaka , Takekawa Daiki , Kudo Takashi , Sawada Kaori , Mikami Tatsuya , Hirota Kazuyoshi 
Published: June 2022

AbstractRelationships between the neutrophil–lymphocyte ratio (NLR) and/or the platelet-lymphocyte ratio (PLR) and neuroinflammatory diseases have been reported. Depression is also associated with neuroinflammation. Here, we determined the association between the NLR, PLR, and depressive symptoms. This cross-sectional study is a secondary analysis of the data of the Iwaki Health Promotion Project 2017. We analyzed the characteristics and laboratory data of 1,015 Japanese subjects (597 females, 408 males) including their NLR and PLR values. We assigned the subjects with a Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16 to the depressive symptoms group. We performed a multivariate logistic regression analysis to determine whether the NLR and/or PLR were associated with depressive symptoms (CES-D ≥ 16). Two hundred subjects (19.7%; 122 [20.4%] females, 78 [19.1%] males) were assigned to the depressive symptoms group. There were significant differences between the non-depressive symptoms and depressive symptoms groups in the NLR [median (25th to 75th percentile): 1.54 (1.24, 1.97) vs. 1.76 (1.32, 2.37), P = 0.005] and the PLR [median (25th to 75th percentile): 123.7 (102.0, 153.9) vs. 136.8 (107.0, 166.5), P = 0.047] in males, but not in females. The multivariate logistic regression analysis demonstrated that the NLR was significantly associated with depressive symptoms in males (adjusted odds ratio: per 1 increase, 1.570; 95% confidence interval: 1.120–2.220; P = 0.009). In conclusion, our findings indicate that higher NLR may be associated with depressive symptoms in males.
Detection of SARS-CoV-2 in subcutaneous fat but not visceral fat, and the disruption of fat lymphocyte homeostasis in both fat tissues in the macaque
Authors: Olivo Anaëlle , Marlin Romain , Lazure Thierry , Maisonnasse Pauline , Bossevot Laetitia , Mouanga Christelliah , Lemaitre Julien , Pourcher Guillaume , Benoist Stéphane , Le Grand Roger , Lambotte Olivier , Dereuddre-Bosquet Nathalie , Bourgeois Christine 
Published: June 2022

AbstractThe well documented association between obesity and the severity of SARS-CoV-2 infection raises the question of whether adipose tissue (AT) is impacted during this infection. Using a model of SARS-CoV-2 infection in cynomolgus macaques, we detected the virus within subcutaneous AT (SCAT) but not in visceral AT (VAT) or epicardial AT on day 7 post-infection. We sought to determine the mechanisms responsible for this selective detection and observed higher levels of angiotensin-converting-enzyme-2 mRNA expression in SCAT than in VAT. Lastly, we evaluated the immunological consequences of SARS-CoV-2 infection on AT: both SCAT and VAT T cells showed a drastic reduction in CD69 expression, a standard marker of resident memory T cell in tissue, that is also involved in the migratory and metabolic properties of T cells. Our results demonstrate that in a model of mild infection, SCAT is selectively infected by SARS-CoV-2 although changes in the immune properties of AT are observed in both SCAT and VAT.
Resource allocation for multi‐IRS‐aided D2D communication underlying cellular networks
Authors: Forouzanmehr Maliheh , Akhlaghi Soroush , Khalili Ata 
Published: June 2022

AbstractThis paper investigates the resource allocation design in device‐to‐device (D2D) communication underlying cellular networks, which is assisted by multiple intelligent reflecting surfaces (IRSs) deployed at the cell boundary to enhance desired signals and mitigate interference between D2D pairs and CUs. In this regard, a multi‐objective optimization problem (MOOP) framework is formulated to jointly maximize the downlink sum‐rate of the D2D pairs and cellular users (CUs). To doing so, the MOOP is first converted into a single‐objective optimization problem (SOOP) by invoking the weighted sum method. Next, to facilitate the high‐coupled non‐convex SOOP formulation, it is decomposed into two sub‐problems through the alternative optimization method. For the first sub‐problem, the inner approximation and successive convex approximations are adopted for jointly allocating D2D transmission power, subcarrier assignment, and transmit beamforming matrix at the BS. For the second sub‐problem, an iterative algorithm based on the penalty‐based method as well as Fenchel's duality approach is adopted to design the passive beamforming matrices at IRSs, which is guaranteed to rapidly converge to a stationary point. Simulation results reveal that a non‐trivial trade‐off between the total throughput of CUs and D2D pairs exist. Furthermore, the proposed framework significantly outperforms existing works addressed in the literature.
Low‐light image haze removal with light segmentation and nonlinear image depth estimation
Authors: Lv Jianwei , Qian Feng , Zhang Bao 
Published: June 2022

AbstractHazy image obtained in the low‐light environment has the characteristics of low contrast, non‐uniform illumination, color cast and much noise. In this paper, a method is put forward which can be properly applied to recover low‐light hazy images. The original image is first decomposed into glow layer and haze layer with a modified color channel transformation for glow artifacts and color balanced. A new light segmentation function is proposed next by using gamma correction of channel difference and setting threshold levels to determine if the pixel belongs to light source regions. Then the ambient illuminance map is estimated using maximum reflectance prior to computing the atmosphere light in the light and non‐light regions. Finally, a novel nonlinear image depth estimation model is established to build the relationship between the image depth map and three image features including luminance, saturation and gradient map for the light areas. The experimental results prove that the dehazing algorithm is reliable for removing haze and glow artifacts of active light sources, reducing much noise and improving the visibility.
Multi‐future Transformer: Learning diverse interaction modes for behaviour prediction in autonomous driving
Authors: He Baotian , Li Yibing 
Published: June 2022

AbstractPredicting the future behaviour of neighbouring agents is crucial for autonomous driving. This task is challenging, largely because of the diverse unobservable intent of each agent which is further complicated by the complex interaction possibilities between them. The authors propose a multi‐future Transformer framework that implicitly models the multi‐modal joint distribution by capturing the diverse interaction modes of the scene. To this end, a parallel interaction module is constructed, whereby each interaction block learns the joint agent–agent and agent–map interactions for possible future evolution. The model can perform likelihood estimation from the perspective of both the joint distribution of the scene and marginal distribution of each agent. Combined with the proposed scene‐level winner‐take‐all loss strategy complementary to the model architecture, the best performance is achieved for both target agent prediction and scene prediction tasks in a single model. To better utilise the scene context, comprehensive control experiments were conducted highlighting the importance of fine‐grained scene representation with content‐adaptive aggregation and late fusion of semantic attributes. The method, evaluated on the popular Argoverse forecasting dataset, outperformed previous methods while maintaining low model complexity.
Hygiene in der Dermatologie: multiresistente gram-negative Stäbchen (MRGN) und Vancomycin-resistente Enterokokken (VRE)
Authors: Schlatterer Kathrin , Maxeiner Horst-Günter , Zouboulis Christos C. , Daeschlein Georg 
Published: June 2022

ZusammenfassungBakterielle Besiedlungen von Haut und Wunden sowie Infektionen mit Problemkeimen spielen in der Dermatologie eine wichtige Rolle. Neben Methicillin-resistenter Staphylococcus aureus (MRSA) finden sich auch zunehmend MRGN und VRE bei Wund- und Weichteilinfektionen. Da sowohl für multiresistente gram-negative Stäbchen (MRGN) als auch Vancomycin-resistente Enterokokken (VRE) das Haupt-Reservoir der menschliche Darm ist, ist eine Sanierung nicht möglich. Daher ist das Ziel, bei diesen beiden multiresistenten Erregerarten durch Prävention bei Risikopatienten und geeignete Hygiene-Maßnahmen eine Reduktion in zusätzlichen Reservoiren wie bspw. chronischen Wunden zu erreichen sowie durch richtigen Einsatz von Antibiotika eine weitere Zunahme von MRGN- und VRE-Inzidenzen zu verhindern. Aus diesem Grund ist bei der Infektionsprävention ein besonderer Fokus auf das Hygienemanagement zu legen. Dieses soll praxisnah, effizient und nachvollziehbar, damit also auch vermittelbar sein. Die Antibiotikastrategie soll so ausgestaltet sein, dass die Selektion resistenter Erreger möglichst verhindert wird. Dies gilt gleichermaßen für das Krankenhaus wie auch das ambulante Umfeld von Patienten.
I-131 metaiodobenzylguanidine therapy is a significant treatment option for pheochromocytoma and paraganglioma
Authors: Zhang Xue , Wakabayashi Hiroshi , Kayano Daiki , Inaki Anri , Kinuya Seigo 
Published: June 2022

Abstract
Aim Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours of chromaffin cells. Several modalities are currently available to treat patients with PPGL. These treatment modalities include surgery, chemotherapy, molecular targeted therapy and radiopharmaceuticals.
Methods I-131 metaiodobenzylguanidine (mIBG), a classic radiopharmaceutical, can be taken up through specific receptors and sited into many, but not all, PPGL cells.
Results Many studies have investigated the efficacy and toxicity of I-131 mIBG therapy. These studies reported significant results in terms of objective, hormonal and symptomatic responses as well as tolerable toxicities in patients.
Conclusion This article reviews the reported experiences of patients who underwent I-131 mIBG therapy for PPGL with a focus on functions and deficiencies of the therapy.
Associations of Plasma Bioactive Adrenomedullin Levels with Cardiovascular Risk Factors in BRCA1/2 Mutation Carriers
Authors: Lammert Jacqueline , Basrai Maryam , Struck Joachim , Hartmann Oliver , Engel Christoph , Bischoff Stephan C. , Berling-Ernst Anika , Halle Martin , Kiechle Marion , Grill Sabine 
Published: June 2022

AbstractBackground Cardiovascular disease (CVD) is an important cause of morbidity and mortality in breast cancer survivors. Effective screening modalities to identify CVD risk are lacking in this population. Adrenomedullin (ADM) has been suggested as a biomarker for subclinical cardiac dysfunction in the general population. Levels of ADM have been proven to be responsive to lifestyle changes that lead to improved cardiovascular health. As BRCA1/2 mutation carriers are deemed to be at an increased risk for CVD, the aim of this study was to examine plasma ADM levels in a cohort of BRCA mutation carriers and to assess their association with cardiovascular risk factors.Methods Plasma ADM concentrations were measured in 292 female BRCA1/2 mutation carriers with and without a history of breast cancer. Subjects were classified into high versus low ADM levels based on the median ADM level in the entire cohort (13.8 pg/mL). Logistic regression models were used to estimate the odds ratios (OR) of having elevated ADM levels by several cardiovascular risk factors.Results Of all women (median age: 43 years), 57.5% had a previous diagnosis of breast cancer. The median time between diagnosis and study entry was three years (range: 0 – 32 years). Women presenting with metabolic syndrome had 22-fold increased odds of having elevated ADM levels (p < 0.001). Elevated ADM levels were associated with lower cardiorespiratory fitness (OR = 0.88, p < 0.001) and several parameters of obesity (p < 0.001). ADM levels were higher in women who have ever smoked (OR = 1.72, p = 0.02). ADM levels were not associated with a previous diagnosis of breast cancer (p = 0.28).Conclusions This is the first study in BRCA mutation carriers that has linked circulating ADM levels to traditional cardiovascular risk factors. The long-term clinical implications of these findings are yet to be determined.
What size cutoff level should be used to implement optical polyp diagnosis?
Authors: Taghiakbari Mahsa , Pohl Heiko , Djinbachian Roupen , Anderson Joseph C. , Metellus Danny , Barkun Alan N. , Bouin Mickael , von Renteln Daniel 
Published: June 2022

Abstract
Background The risk of advanced pathology increases with polyp size, as does the potential for mismanagement when optical diagnosis is used. This study aimed to evaluate the proportion of patients who would be assigned inadequate surveillance intervals when different size cutoffs are adopted for use of optical diagnosis.
Methods In a post hoc analysis of three prospective studies, the use of optical diagnosis was evaluated for three polyp size groups: 1–3, 1–5, and 1–10 mm. The primary outcome was the proportion of patients in whom advanced adenomas were found and optical diagnosis resulted in delayed surveillance. Secondary outcomes included agreements between surveillance intervals based on high confidence optical diagnosis and pathology outcomes, reduction in histopathological examinations, and proportion of patients who could receive an immediate surveillance recommendation.
Results We included 3374 patients (7291 polyps ≤ 10 mm) undergoing complete colonoscopies (median age 66.0 years, 75.2 % male, 29.6 % for screening). The percentage of patients with advanced adenomas and either 2- or 7-year delayed surveillance intervals (n = 79) was 3.8 %, 15.2 %, and 25.3 % for size cutoffs of 1–3, 1–5, and 1–10 mm polyps, respectively (P < 0.001). Surveillance interval agreements between pathology and optical diagnosis for the three groups were 97.2 %, 95.5 %, and 94.2 %, respectively. Total reductions in pathology examinations for the three groups were 33.5 %, 62.3 %, and 78.2 %, respectively.
Conclusion A 3-mm cutoff for clinical implementation of optical diagnosis resulted in a very low risk of delayed management of advanced neoplasia while showing high surveillance interval agreement with pathology and a one-third reduction in overall requirement for pathology examinations.
Bite-on-bite biopsies for the detection of residual esophageal cancer after neoadjuvant chemoradiotherapy
Authors: van der Bogt Ruben D. , van der Wilk Berend J. , Oudijk Lindsey , Schoon Erik J. , van Lijnschoten Gesina , Corporaal Sietske , Nieken Judith , Siersema Peter D. , Bisseling Tanya M. , van der Post Rachel S. , Quispel Rutger , van Tilburg Arjan , Oostenbrug Liekele E. , Riedl Robert G. , Hol Lieke , Kliffen Mike , Nikkessen Suzan , Eyck Ben M. , van Lanschot J. Jan B. , Doukas Michael , Spaander Manon C. W. 
Published: June 2022

Background Active surveillance after neoadjuvant treatment is increasingly implemented. The success of this strategy relies on the accurate detection of residual cancer. This study aimed to assess the diagnostic value of a second (bite-on-bite) biopsy for the detection of residual esophageal cancer and to correlate outcomes to the distribution of residual cancer found in the resection specimen.
Methods A multicenter prospective study of esophageal cancer patients undergoing active surveillance after neoadjuvant chemoradiotherapy was performed. At clinical response evaluations, an upper gastrointestinal (GI) endoscopy was performed with at least four bite-on-bite biopsies of the primary tumor site. First and second biopsies were analyzed separately. Patients with histopathological evidence of residual cancer were included in the primary analysis. Two pathologists blinded for biopsy outcome examined all resection specimens.
Results Between October 2017 and July 2020, 626 upper GI endoscopies were performed in 367 patients. Of 138 patients with residual cancer, 112 patients (81 %) had at least one positive biopsy. In 14 patients (10 %) only the first biopsy was positive and in 25 patients (18 %) only the second biopsy (P = 0.11). Remarkably, the rates of patients with tumor-free mucosa and deeper located tumors were higher in patients detected by the first biopsy. The second biopsy increased the false-positive rate by 3 percentage points. No adverse events occurred.
Conclusions A second (bite-on-bite) biopsy improves the detection of residual esophageal cancer by almost 20 percentage points, at the expense of increasing the false-positive rate by 3 percentage points. The higher detection rate is explained by the higher number of biopsies obtained rather than by the penetration depth.