bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dental education during the pandemic – cross-sectional lecturer-side evaluation for the use of digital teaching concepts
Authors: Nold Ephraim , Demeter Vivienne , Erdelt Kurt-Jürgen , Edelhoff Daniel , Liebermann Anja 
Published: July 2022

Background: The COVID-19 pandemic resulted in significant restrictions on dental teaching. The aim of this investigation was to evaluate the attitudes of faculty members towards digital teaching formats and the effort creating digital lectures. We hypothesized that on the lecturer side there is no difference between the various digital teaching concepts in terms of workload and effort and that there is no increase in workload and effort when switching to digital teaching concepts. Methods: All German dental faculties were invited to the online survey by an anonymous voluntary questionnaire from January to April 2021. The questionnaire consisted of 27 questions that could be answered with a visual analog scale, free text answers, or with fixed answer options. Data was analyzed using the Kolmogorov-Smirnov test and an exploratory data analysis (α=0.05). Results: Before the pandemic, 24.8% of the participating lecturers were using digital teaching and 64.4% had no previous experience. After the outbreak of the pandemic 100% of the dental teaching was initially held online. More than 80% of the lecturers stated that they offer online lectures (86.1%), online seminars (81.2%), and/or online bedside teaching (33.7%). 88.1% see face-to-face teaching as the preferred teaching format. The lecturers also see the greatest opportunities for interaction in the area of analog teaching and significantly worse in synchronous and asynchronous digital teaching. In the course of the pandemic, respondents' attitudes towards online teaching improved in the median of 24.0 to a median of 50.0. Conclusions: Faculty members have positively changed their attitudes towards online teaching formats over the course of the pandemic. Although they see the greatest learning success in conventional face-to-face teaching formats and the creation of digital lectures is associated with a higher effort, they want more online lessons in the future.
The effect of ingestion of red dragon fruit extract on levels of malondialdehyde and superoxide dismutase after strenuous exercise in rats (Rattus norvegicus)
Authors: Rusip Gusbakti , Ilyas Syafrudin , Lister I. Nyoman Ehrich , Ginting Chrismis N. , Mukti Indra 
Published: July 2022

Background: Prolonged activation of skeletal muscles causes a decrease in the production of fatigue. Exercise with strenuous intensity causes an increase in Reactive Oxygen Species (ROS). An increase in free radicals causes oxidative stress resulting in damage to cell function to mitochondrial dysfunction, and fatigue. This study aimed to determine the antioxidant potential of red dragon fruit (RDF) to delay fatigue due to oxidative stress, which improves cell function in mitochondria. Methods: 25 male rats (Rattus norvegicus) aged three months were divided into five groups: Group K1 was N.A. (No Activity) but drinking and eating; Group K2 performed strenuous exercise without RDF treatment; Groups 3, 4, and 5 (P1, P2 and P3, respectively) performed strenuous exercise and were treated with 75 mg kg-1.bw, 150 mg kg-1.bw, and 300 mg kg-1.bw of RDF extract, respectively. The exercise for the rats involved intense swimming for 20 minutes every day, four days a week for 31 days. Malondialdehyde (MDA) was measured with the ELISA and histopathology for muscle soleus and lung tissue. Results: Strenuous exercise followed by RDF extract ingestion was compared for fatigue in terms of duration and time; before (24.55±1.38 minute) and after (95.31±7.82 minute) and led to a significant difference of 39% (p<0.01). The study also compared MDA before and after RDF extract ingestion in the K2 vs. the P1 group (p<0.05). At the same time, P2 differed more significantly (p<0.01). This indicated a spread of free radicals and featured histopathological damage of muscle cells. However, ingestion of RDF extract leads to improvement of soleus muscle cells; thus, repairs cell function, delaying fatigue. Conclusion: This study confirmed that strenuous exercise, which causes an increase in ROS, intensifies free radicals with RDF extract ingestion and declines oxidative stress, repairing cell function and delaying fatigue.
Local brain-state dependency of effective connectivity: a pilot TMS–EEG study
Authors: Granö Ida , Mutanen Tuomas P. , Tervo Aino , Nieminen Jaakko O. , Souza Victor H. , Fecchio Matteo , Rosanova Mario , Lioumis Pantelis , Ilmoniemi Risto J. 
Published: July 2022

Background: Spontaneous cortical oscillations have been shown to modulate cortical responses to transcranial magnetic stimulation (TMS). However, whether these oscillations influence cortical effective connectivity is largely unknown. We conducted a pilot study to set the basis for addressing how spontaneous oscillations affect cortical effective connectivity measured through TMS-evoked potentials (TEPs).Methods: We applied TMS to the left primary motor cortex and right pre-supplementary motor area of three subjects while recording EEG. We classified trials off-line into positive- and negative-phase classes according to the mu and beta rhythms. We calculated differences in the global mean-field amplitude (GMFA) and compared the cortical spreading of the TMS-evoked activity between the two classes.Results: Phase affected the GMFA in four out of 12 datasets (3 subjects × 2 stimulation sites × 2 frequency bands). Two of the observed significant intervals were before 50 ms, two between 50 and 100 ms, and one after 100 ms post-stimulus. Source estimates showed complex spatial differences between the classes in the cortical spreading of the TMS-evoked activity.Conclusions: TMS-evoked effective connectivity seems to depend on the phase of local cortical oscillations at the stimulated site. This work paves the way to design future closed-loop stimulation paradigms.
Performance evaluation of a multinational data platform for critical care in Asia
Authors:   Collaboration for Research, Implementation and Training in Critical Care - Asia Investigators, Pisani Luigi , Rashan Thalha , Shamal Maryam , Ghose Aniruddha , Kumar Tirupakuzhi Vijayaraghavan Bharath , Tripathy Swagata , Aryal Diptesh , Hashmi Madiha , Nor Basri , Lam Minh Yen , Dondorp Arjen M. , Haniffa Rashan , Beane Abi 
Published: July 2022

Background: The value of medical registries strongly depends on the quality of the data collected. This must be objectively measured before large clinical databases can be promoted for observational research, quality improvement, and clinical trials. We aimed to evaluate the quality of a multinational intensive care unit (ICU) network of registries of critically ill patients established in seven Asian low- and middle-income countries (LMICs). Methods: The Critical Care Asia federated registry platform enables ICUs to collect clinical, outcome and process data for aggregate and unit-level analysis. The evaluation used the standardised criteria of the Directory of Clinical Databases (DoCDat) and a framework for data quality assurance in medical registries. Six reviewers assessed structure, coverage, reliability and validity of the ICU registry data. Case mix and process measures on patient episodes from June to December 2020 were analysed. Results: Data on 20,507 consecutive patient episodes from 97 ICUs in Afghanistan, Bangladesh, India, Malaysia, Nepal, Pakistan and Vietnam were included. The quality level achieved according to the ten prespecified DoCDat criteria was high (average score 3.4 out of 4) as was the structural and organizational performance -- comparable to ICU registries in high-income countries. Identified strengths were types of variables included, reliability of coding, data completeness and validation. Potential improvements included extension of national coverage, optimization of recruitment completeness validation in all centers and the use of interobserver reliability checks. Conclusions: The Critical Care Asia platform evaluates well using standardised frameworks for data quality and equally to registries in resource-rich settings.
Participatory Visual Methods with caregivers of children with Congenital Zika Syndrome in Colombia: A case study
Authors: Reichenberger Veronika , Smythe Tracey , Hameed Shaffa , Rubiano Perea Luisa Consuelo , Shakespeare Tom , Penn-Kekana Loveday , Kuper Hannah 
Published: July 2022

Background: This study explores the acceptability and feasibility of the use of two different Participatory Visual Methods (Participatory Video and Digital Storytelling) in gathering information on the experiences and perspectives of carers of children with Congenital Zika Syndrome within Colombia. Methods: Participatory Video was used to assess the impact of the Juntos parent-support intervention in the lives of carers, and Digital Storytelling was used to explore the healthcare access for these children. In-depth interviews were conducted to probe participants on their views of these methods. Results: One Participatory Video was produced and four Digital Stories. Of the initial eight caregivers who took part in the Participatory Video process, four completed both the Digital Storytelling process and an in-depth interview about their experiences. The main factors shaping participants’ experiences related to the skills learned in making the videos, the feeling of collectiveness and the control over the processes. Conclusion: Women with children with Congenital Zika Syndrome have reported feeling marginalised and misunderstood in daily life. This case study found that Participatory Visual Methods is acceptable and feasible. Moreover, these approaches can support groups in different aspects, such as providing a space to share their stories creatively, hear others in similar situations as them and increase the feeling of community.
Weakly Supervised Multi-output Regression via Correlated Gaussian Processes
Authors: Chung Seokhyun , Al Kontar Raed , Wu Zhenke 
Published: July 2022

Multi-output regression seeks to borrow strength and leverage commonalities across different but related outputs in order to enhance learning and prediction accuracy. A fundamental assumption is that the output/group membership labels for all observations are known. This assumption is often violated in real applications. For instance, in healthcare data sets, sensitive attributes such as ethnicity are often missing or unreported. To this end, we introduce a weakly supervised multi-output model based on dependent Gaussian processes. Our approach is able to leverage data without complete group labels or possibly only prior belief on group memberships to enhance accuracy across all outputs. Through intensive simulations and case studies on insulin, testosterone and body fat data sets, we show that our model excels in multi-output settings with missing labels while being competitive in traditional fully labeled settings. We end by highlighting the possible use of our approach in fair inference and sequential decision making. History: Irad Ben-Gal served as the senior editor for this article. Funding: This research was supported in part by the National Science Foundation’s Cyber-Physical Systems (CPS) Program [Award 1931950]. Data Ethics & Reproducibility Note: The code capsule is available on Code Ocean at https://codeocean.com/capsule/2590027/tree/v1 and at https://doi.org/10.1287/ijds.2022.0018 .
Cavity-Backed Slot V2X Antenna for Automotive Applications
Authors: Khalifa Mohamed O. , Yacoub Ahmad M. , Aloi Daniel N. 
Published: July 2022

In this work, a cavity-backed slot antenna has been designed to cover vehicle-to-everything (V2X) frequencies (5.85−5.9255.85-5.925 GHz). The antenna is made to be easily integrated in a vehicle windshield or rear mirror. The cavity-backed slot antenna does not require a ground plane to sit on which makes it an ideal model for below horizon performance. Antenna simulation has been done using high-frequency structure simulator (HFSS) and then on-foam and on vehicle’s windshield measurements have been carried out inside an anechoic chamber. The proposed antenna achieved a linear average gain (LAG) above 2.5 dBi in the targeted V2X elevation and azimuth angles with better than 15 dB return loss. The antenna performance has been reported in terms of reflection coefficient, surface current density, radiation pattern, LAG, and efficiency.
Near-infrared sensitive two-wave mixing adaptive interferometer based on a liquid crystal light valve with a semiconductor substrate
Authors: Shcherbin Konstantin , Gvozdovskyy Igor , Shumelyuk Alexandr , Slagle Jonathan , Evans Dean R. 
Published: July 2022

Two-wave mixing adaptive interferometer based on a liquid crystal light valve with a semiconductor GaAs substrate is realized and studied at 1064 nm wavelength. The local response of the dynamic hologram recorded in the liquid crystal layer of the light valve allows for detection of small phase modulations of the object beam. The characteristics of the interferometer are estimated experimentally. The temporal adaptability lies in the subsecond range. The large optical nonlinearity of the cell is favorable for measurements of small displacements with high sensitivity.
Axial light loss of monocytes as a readily available prognostic biomarker in patients with suspected infection at the emergency department
Authors: de Hond Titus A. P. , Hamelink Wout J. , de Groot Mark C. H. , Hoefer Imo E. , Oosterheert Jan Jelrik , Haitjema Saskia , Kaasjager Karin A. H. 
Published: July 2022

Objectives
To evaluate the prognostic value of the coefficient of variance of axial light loss of monocytes (cv-ALL of monocytes) for adverse clinical outcomes in patients suspected of infection in the emergency department (ED).

Methods
We performed an observational, retrospective monocenter study including all medical patients ≥18 years admitted to the ED between September 2016 and June 2019 with suspected infection. Adverse clinical outcomes included 30-day mortality and ICU/MCU admission <3 days after presentation. We determined the additional value of monocyte cv-ALL and compared to frequently used clinical prediction scores (SIRS, qSOFA, MEWS). Next, we developed a clinical model with routinely available parameters at the ED, including cv-ALL of monocytes.

Results
A total of 3526 of patients were included. The OR for cv-ALL of monocytes alone was 2.21 (1.98–2.47) for 30-day mortality and 2.07 (1.86–2.29) for ICU/MCU admission <3 days after ED presentation. When cv-ALL of monocytes was combined with a clinical score, the prognostic accuracy increased significantly for all tested scores (SIRS, qSOFA, MEWS). The maximum AUC for a model with routinely available parameters at the ED was 0.81 to predict 30-day mortality and 0.81 for ICU/MCU admission.

Conclusions
Cv-ALL of monocytes is a readily available biomarker that is useful as prognostic marker to predict 30-day mortality. Furthermore, it can be used to improve routine prediction of adverse clinical outcomes at the ED.

Clinical trial registration
Registered in the Dutch Trial Register (NTR) und number 6916.
Clinical, radiological and pathological characteristics of moderate to fulminant psittacosis pneumonia
Authors: Li Xiaoying , Xiao Tao , Hu Pengzhi , Yan Kun , Wu Jiongxing , Tu Xinya , Tang Yishu , Xia Hong 
Published: July 2022

Background
Psittacosis pneumonia is a community-acquired pneumonia caused by Chlamydia psittaci. It is usually under-diagnosed due to its atypical clinical presentation and lack of routine laboratory tests.

Methods
To better understand the clinical features, 52 patients diagnosed with psittacosis pneumonia by metagenomic next-generation sequencing (mNGS) were enrolled in this study. The clinical, radiological and pathological characteristics were retrospectively analyzed.

Results
The onset of psittacosis pneumonia in this study occurred all year round, with a peak from December to January. Most of the patients were 51–80 years old. About 65.38% of patients had a history of exposure to poultry or parrots. Abnormalities of multiple clinical signals were detected in these patients. Elevated levels of neutrophil ratio, C-reactive protein, erythrocyte sedimentation rate, and procalcitonin were detected in most patients. Radiological evidence revealed air-space consolidation or ground-glass opacities in lungs of all patients, which is the typical feature of psittacosis pneumonia. In addition, hyperemia, swelling of bronchial mucosa, and bronchial patency were detected by bronchoscopy in all patients, and bronchial sub-mucosal edema, inflammatory cells infiltration and alveolar epithelial hyperplasia were identified in the bronchial mucosa and alveolar tissue. Beta-lactam antibiotics were administered for empirical treatment before mNGS in 17 patients but showed no improvement. The treatment was switched to doxycycline or moxifloxacin immediately since psittacosis pneumonia were suspected and confirmed by mNGS detection (within 48 hours). After receiving adjustment of treatment, 94.23% (49/52) of patients were cured successfully.

Conclusions
In conclusion, mNGS may be a promising approach for clinical diagnosis of psittacosis. For patients with a history of exposure to birds, hyperpyrexia, nonproductive cough, multiple elevated inflammatory markers, and air-space consolidation in lung, psittacosis pneumonia should be considered, especially when beta-lactam antibiotics showed limited efficacy.
Hiperpotasemia mantenida en Atención Primaria en una paciente sin sintomatología de interés. ¿Cuándo sospechar de una pseudohiperpotasemia familiar?
Authors: Castillo Pérez Carlos , Rodríguez Alonso Laura , Prados Boluda Adrián , Cebrián Ballesteros Marta , Torrubia Dodero Blanca 
Published: July 2022

Resumen

Objetivos
El estudio y abordaje de un caso clínico de una paciente con elevaciones de potasio en las sucesivas revisiones sin justificación clínica.

Caso clínico
Presentamos un caso clínico de una paciente con una elevación de potasio en las sucesivas analíticas realizadas por su médico de Atención Primaria, sin justificación clínica. La paciente es derivada a Nefrología, con potasemias mantenidas de 5,3–5,9 mmol/L en suero sin más datos de interés, tratada con dieta baja en potasio sin éxito. En el estudio completo no se encuentra ninguna causa orgánica que justifique la elevación.

Conclusiones
Ante resultados discordantes entre las cifras de potasio y el motivo de consulta, y tras haber descartado otras causas preanalíticas o patológicas, se propone que la posible causa sea una pseudohiperpotasemia familiar. Se realiza un protocolo de incubación de la muestra a diferentes tiempos y temperaturas para demostrar su influencia en los niveles de potasio en sangre, por lo que se concluye el diagnóstico más probable de pseudohiperpotasemia familiar. Finalmente, la paciente es dada de alta por parte de Nefrología, con lo que puede retomar una dieta normal.
Patient-based real-time quality control for quantitative hepatitis B virus DNA test using moving rate of positive and negative patient results
Authors: Li Tingting , Li Jiamin , Cao Shunwang , Wang Yi , Wang Hongmei , Zhang Cheng , Ke Peifeng , Huang Xianzhang 
Published: July 2022

Abstract

Objectives
Patient-based real-time quality control (PBRTQC) has gained increasing attention in the field of laboratory quality management in recent years. However, PBRTQC has not been reported for use in molecular diagnostics. This study introduces PBRTQC to quantitative hepatitis B virus (HBV) DNA test using moving rate (MR) of positive and negative patient results.

Methods
In contrast to the MR protocols described in other literature, MR protocol for HBV-DNA test has an additional logarithmic transformation and binary conversion steps before using a common statistical process control algorithm, such as the MR. We used all patient test results of HBV-DNA assay from August 2018 to August 2021 at the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, for parameters setting, optimization, and performance validation. The false rejection rate, error detection curves and validation charts were used to assess the MR protocols.

Results
The false rejection rates of two MR protocols were both <0.7%. The optimal block sizes for positive and negative errors in each cut-off value were not the same, so we first proposed a combined protocol that used different block size to detect negative and positive errors. It turned out that the combined protocols outperformed the simple protocols for each cut-off value, especially detecting positive errors.

Conclusions
The performances of MR protocols using positive or negative patient results to detect constant errors of HBV-DNA test could meet laboratory requirements. Therefore, we have provided an effective alternative tool for internal quality control in the field of molecular diagnostics.
A new sonographic marker in the diagnosis of prenatal bilateral renal agenesis, segmental anterior deviation of the aorta
Authors: Özdemir Halis , Özdemir Belma Gözde , Kavak Songül Yerlikaya , Şık Şule 
Published: July 2022

Abstract

Objectives
Bilateral renal agenesis is a rare congenital anomaly that is associated with high neonatal mortality. Bilateral renal agenesis is most often present with anhydramniosis in the mid-trimester.

Case presentation
We report a case of bilateral renal agenesis diagnosed prenatally. We presented the ultrasound and pathology images of this fetus with a new sonographic sign, segmental anterior deviation in the abdominal aorta.

Conclusions
To our knowledge, this is the first reported case of a fetus with a segmental aortic anterior deviation.
Scripting Swiss smiles: a sociolinguistic analysis of affective-discursive practices in a Swiss call centre
Authors: Flubacher Mi-Cha 
Published: July 2022

AbstractRevisiting data from a sociolinguistic ethnography of an in-bound Swiss call centre (2010–2011), I will show how the scripted smile of agents is fused strategically with the use of the dialect in order to produce ‘affective-discursive practices’ that aim for a projection of quality of service. These practices include ‘scripted affective efficiency’ and the ‘stylization of Swiss authenticity’. Inherently embedded in and emblematic of the political economy, these particular affective-discursive practices are conducive to the company’s branding strategies of authenticity, directly linked to market distinction and profit generation. From today’s standpoint, i.e. 10 years later, transformations in ICT (Information and Communications Technology) have displayed the limits of these affective practices and their underlying discourses and ideologies in the face of cost-benefit analyses when the number of incoming calls dwindled due to the development of smartphones. This paper will discuss affective-discursive practices from a political-economic and critical sociolinguistic perspective.
The pedagogy of love: a register of precarised English teachers in Chile
Authors: Anabalon Schaaf Rommy 
Published: July 2022

AbstractIn this contribution, I will look at the imbrication of language, labour and affective capitalism in the exemplary context of a Chilean private university, as part of a larger sociolinguistic ethnography project that seeks to examine processes of precarisation in university teachers. I argue that the affective-discursive practices used by three English Language teachers, which they called the pedagogy of love, constitute a register. This register is one of the many available to women and men, which they can manage, negotiate, manipulate and capitalise on. I show in this article the way teachers enact, align with and detach from the register to make sense of their professional identities and navigate a precarious higher education market, and how the university benefits from it to regulate teachers’ labour and students’ expectations and eventually, obtain financial stability.