bluuebunny/crossref_metadata_2025_split huggingface dataset:
P50 implies adverse clinical outcomes in pediatric acute respiratory distress syndrome by reflecting extrapulmonary organ dysfunction
Authors: Kim Yura , Jung Jae Hwa , Kim Ga Eun , Park Mireu , Lee Myeongjee , Kim Soo Yeon , Kim Min Jung , Kim Yoon Hee , Kim Kyung Won , Sohn Myung Hyun 
Published: August 2022

AbstractHypoxemia and multiple organ dysfunction are significant contributors to mortality in patients with pediatric acute respiratory distress syndrome (PARDS). P50, the oxygen tension at which hemoglobin is 50% saturated, is a measure of hemoglobin-oxygen affinity, and its alteration might have implications for tissue hypoxia and organ dysfunction. The purpose of this single-center, retrospective study was to evaluate P50 levels in PARDS and to determine the association between P50 and clinical outcomes. The study included 212 children diagnosed with PARDS according to the Pediatric Acute Lung Injury Consensus Conference definition who required invasive mechanical ventilation and had arterial blood gas results of hemoglobin oxygen saturation < 97% at the time of diagnosis. P50 levels were calculated using Doyle’s method, and organ dysfunction was assessed using the Pediatric Logistic Organ Dysfunction-2 score. Most patients exhibited more than one dysfunctional extrapulmonary organ at PARDS onset. P50 increased with increasing PARDS severity (mild (26.6 [24.9–29.6]), moderate (26.8 [25.0–29.5]), and severe PARDS (29.1 [26.1–32.4] mmHg; P = 0.025). Moreover, P50 demonstrated a significant positive association with extrapulmonary organ dysfunction score (β = 0.158, P = 0.007) and risk of mortality (adjusted hazard ratio, 1.056; 95% confidence interval, 1.015–1.098; P = 0.007), irrespective of initial PARDS severity. The relationship between P50 and mortality was largely mediated by extrapulmonary organ dysfunction. A high P50 value at the time of PARDS diagnosis may be associated with mortality via dysfunctional extrapulmonary organs. Future studies should consider P50 as a potential candidate index for risk stratification of PARDS patients.
Digital reconstruction of infraslow activity in human intracranial ictal recordings using a deconvolution-based inverse filter
Authors: Lee Somin , Henry Julia , Tryba Andrew K. , Esengul Yasar , Warnke Peter , Wu Shasha , van Drongelen Wim 
Published: August 2022

AbstractInfraslow activity (ISA) is a biomarker that has recently become of interest in the characterization of seizure recordings. Recent data from a small number of studies have suggested that the epileptogenic zone may be identified by the presence of ISA. Investigation of low frequency activity in clinical seizure recordings, however, has been hampered by technical limitations. EEG systems necessarily include a high-pass filter early in the measurement chain to remove large artifactual drifts that can saturate recording elements such as the amplifier. This filter, unfortunately, attenuates legitimately seizure-related low frequencies, making ISA difficult to study in clinical EEG recordings. In this study, we present a deconvolution-based digital inverse filter that allows recovery of attenuated low frequency activity in intracranial recordings of temporal lobe epilepsy patients. First, we show that the unit impulse response (UIR) of an EEG system can be characterized by differentiation of the system’s step response. As proof of method, we present several examples that show that the low frequency component of a high-pass filtered signal can be restored by deconvolution with the UIR. We then demonstrate that this method can be applied to biologically relevant signals including clinical EEG recordings obtained from seizure patients. Finally, we discuss how this method can be applied to study ISA to identify and assess the seizure onset zone.
The methodology of design of satellite working mechanism of positive displacement machine
Authors: Sliwinski Pawel 
Published: August 2022

AbstractIn this paper is described a methodology of design of satellite mechanism consisting of two non-circular gears (externally toothed rotor and internally toothed curvature) and circular gears (satellites). In the presented methodology is assumed that the rotor pitch line is known, and the curvature pitch line is necessary to designate. The presented methodology applies to mechanisms for which the number of the curvature humps is at least one greater than the number of rotor humps. The selection of the number of gears and the number of teeth in gear and rotor and curvature is also presented. The methodology of calculating the position of the satellite center and the angle of its rotation in order to shape the teeth on the rotor and curvature is presented. The article is also showed different types of satellite mechanisms—satellite mechanisms with the different numbers of humps on the rotor and curvature. The technical parameters of the mechanism for the rotor pitch line described by the cosine function are also presented.
Upconversion photoluminescence excitation reveals exciton–trion and exciton–biexciton coupling in hBN/WS$$_{2}$$/hBN van der Waals heterostructures
Authors: Żuberek Ewa , Majak Martyna , Lubczyński Jakub , Debus Joerg , Watanabe Kenji , Taniguchi Takashi , Ho Ching-Hwa , Bryja Leszek , Jadczak Joanna 
Published: August 2022

AbstractMonolayers of transition-metal dichalcogenides with direct band gap located at the binary $$K_{-}/K_{+}$$

K
-

/

K
+

points of the Brillouin zone are promising materials for applications in opto- and spin-electronics due to strongly enhanced Coulomb interactions and specific spin-valley properties. They furthermore represent a unique platform to study electron–electron and electron–phonon interactions in diverse exciton complexes. Here, we demonstrate processes in which the neutral biexciton and two negative trions, namely the spin-triplet and spin-singlet trions, upconvert light into a bright intravalley exciton in an hBN-encapsulated WS$$_{2}$$

2

monolayer. We propose that the energy gains required in the polarized upconversion photoluminescence originate from different interactions including resonant optical phonons, a cooling of resident electrons and a non-local and an anisotropic electron–hole exchange, respectively. The temperature dependence (7–120 K) of the excitonic upconversion intensity obtained at excitation energies corresponding to the biexciton and trions provides insight into an increasing phonon population as well as a thermally enhanced electron scattering. Our study sheds new light on the understanding of excitonic spin and valley properties of van der Waals heterostructures and improves the understanding of photonic upconversion mechanisms in two-dimensional quantum materials.
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease
Authors: Srinivasan Vasundara , Brognaro Hévila , Prabhu Prince R. , de Souza Edmarcia Elisa , Günther Sebastian , Reinke Patrick Y. A. , Lane Thomas J. , Ginn Helen , Han Huijong , Ewert Wiebke , Sprenger Janina , Koua Faisal H. M. , Falke Sven , Werner Nadine , Andaleeb Hina , Ullah Najeeb , Franca Bruno Alves , Wang Mengying , Barra Angélica Luana C. , Perbandt Markus , Schwinzer Martin , Schmidt Christina , Brings Lea , Lorenzen Kristina , Schubert Robin , Machado Rafael Rahal Guaragna , Candido Erika Donizette , Oliveira Danielle Bruna Leal , Durigon Edison Luiz , Niebling Stephan , Garcia Angelica Struve , Yefanov Oleksandr , Lieske Julia , Gelisio Luca , Domaracky Martin , Middendorf Philipp , Groessler Michael , Trost Fabian , Galchenkova Marina , Mashhour Aida Rahmani , Saouane Sofiane , Hakanpää Johanna , Wolf Markus , Alai Maria Garcia , Turk Dusan , Pearson Arwen R. , Chapman Henry N. , Hinrichs Winfried , Wrenger Carsten , Meents Alke , Betzel Christian 
Published: August 2022

AbstractSARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the additional and vital function of removing ubiquitin and ISG15 (Interferon-stimulated gene 15) from host-cell proteins to support coronaviruses in evading the host’s innate immune responses. We identified three phenolic compounds bound to PLpro, preventing essential molecular interactions to ISG15 by screening a natural compound library. The compounds identified by X-ray screening and complexed to PLpro demonstrate clear inhibition of PLpro in a deISGylation activity assay. Two compounds exhibit distinct antiviral activity in Vero cell line assays and one inhibited a cytopathic effect in non-cytotoxic concentration ranges. In the context of increasing PLpro mutations in the evolving new variants of SARS-CoV-2, the natural compounds we identified may also reinstate the antiviral immune response processes of the host that are down-regulated in COVID-19 infections.
Effect of Video Augmentative and Alternative Communication Technology on Communication During Play With Peers for Children With Autism Spectrum Disorder
Authors: Laubscher Emily , Barwise Allison , Light Janice 
Published: August 2022

Purpose:
Children with autism spectrum disorder (ASD) are at risk for exclusion from play with their peers due to difficulty with communication skills. Video augmentative and alternative communication (AAC) technology has the potential to support communication within the context of play using videos with integrated visual scene displays. This study investigated the effect of a video AAC intervention on the number of turns in which children with ASD demonstrated symbolic communication during interactions with a peer without disabilities. Maintenance of skills, generalization to untrained play scenarios, and stakeholder perceptions of the video AAC technology were also investigated.

Method:
This study used a single-case, multiple-probe design across participant dyads. It included baseline, intervention, maintenance, and generalization phases. Six children with ASD and six peers participated in the study.

Results and Conclusions:
All six participants with ASD demonstrated an increase in the number of turns in which they demonstrated at least one symbolic communication act following intervention, although one participant demonstrated variability in baseline performance, making it difficult to draw conclusions. Results provide preliminary evidence that instruction with video AAC technology can support communication for children with ASD during play interactions with peers.
Radio detection of chemically peculiar stars with LOFAR
Authors: Hajduk Marcin , Leto Paolo , Vedantham Harish , Trigilio Corrado , Haverkorn Marijke , Shimwell Timothy , Callingham Joseph R. , White Glenn J. 
Published: August 2022

Context. Chemically peculiar stars are upper main sequence stars that show anomalies in their optical spectra. These anomalies suggest peculiar chemical abundances of certain elements. Some chemically peculiar stars possess strong magnetic fields. Electrons originating from the ionising stellar wind travel in the magnetosphere of the star and become the source of non-thermal radio and X-ray emission. Several chemically peculiar radio stars have been detected at GHz frequencies.
Aims. We used the Low-Frequency Array (LOFAR) to search for radio emission from chemically peculiar stars to constrain their emission in the frequency band 120–168 MHz. We aimed to use LOFAR observations to test the models for radio emission of chemically peculiar stars.
Methods. We performed a targeted search of known chemically peculiar stars in the fields of the LOFAR Two Metre Survey (LoTSS) Data Release 2 in Stokes I and V. We matched positions of radio sources in the LoTSS-DR2 catalogue with positions of chemically peculiar stars.
Results. We report non-thermal emission at 120–168 MHz from two chemically peculiar stars in Stokes I, BP Boo, and α2 CVn. The ensuing incidence rate at these frequencies is significantly lower than for higher frequencies. This results from the turnover at low frequencies which was predicted from the theory of radio emission from chemically peculiar stars. BP Boo is detected for the first time at radio wavelengths, while α2 CVn had already been detected at higher frequencies. The upper limit of V/I indicates a level of circular polarisation significantly below 60%. We combined data obtained at different frequencies to derive the radio spectrum of α2 CVn. The spectrum is nearly flat beyond turnover at low frequencies. We modelled radio emission for a large magnetosphere and small local magnetic field strength. The amplitude of variation in radio emission with the rotational phase of the system decreases at low frequencies.
Zelltherapie in den Zeiten von SARS-CoV-2
Authors: Wiercinska Eliza , Bönig Halvard 
Published: August 2022

ZusammenfassungEin breites Spektrum von Disruptionen, aber auch blitzschnelle Innovationen, hat
die SARS-CoV-2 Pandemie gebracht. Dieser Übersichtsartikel betrachtet
die Pandemie aus der Warte der Zelltherapie; konkret werden vier Aspekte
untersucht: Wie unterscheiden sich die Risiken von Zelltherapie-Patienten mit
SARS-CoV-2 Infektion und COVID von denen der Allgemeinbevölkerung? Sind
Empfänger von Zelltherapien, hier speziell autologe und allogene
Stammzelltransplantationsempfänger sowie Empfänger von
CAR-T-Zell-Präparaten, klinisch relevant durch SARS-CoV-2 Vakzine
immunisierbar? Welche Auswirkungen hat die Pandemie mit Spenderausfallrisiko und
Zusammenbruch von Supply Chains auf die Versorgung mit Zelltherapeutika? Gibt es
Zelltherapeutika, die bei schwerem COVID therapeutisch nutzbringend eingesetzt
werden können? In aller Kürze, das erwartete massiv
erhöhte Risiko von Zelltherapie-Patienten, im Infektionsfall einen
schweren Verlauf zu erleiden oder zu sterben, wurde bestätigt. Die
Vakzine induziert jedoch bei vielen dieser Patienten humorale und
zelluläre Immunität, wenn auch weniger zuverlässig als
bei Gesunden. Dank kreativer Lösungen gelang es, die Versorgung mit
Zelltherapeutika im Wesentlichen uneingeschränkt aufrecht zu erhalten.
SARS-CoV-2-spezifische T-Zell-Präparate für den adoptiven
Immuntransfer wurden entwickelt, eine therapeutische Konstellation diese
anzuwenden ergab sich jedoch nicht. Therapiestudien mit mesenchymalen
Stromazellen beim schweren COVID laufen weltweit; die Frage der Wirksamkeit
bleibt zurzeit offen, bei jedoch substanziellem Optimismus in der Szene. Einige
der Erkenntnisse und Innovationen aus der SARS-CoV-2-Pandemie können
möglicherweise verallgemeinert werden und so auf die Zeit nach ihrem
Ende langfristig nachwirken.
Subepithelial tumors: How does endoscopic full-thickness resection & submucosal tunneling with endoscopic resection compare with laparoscopic endoscopic cooperative surgery?
Authors: Kahaleh Michel , Bhagat Vicky , Dellatore Peter , Tyberg Amy , Sarkar Avik , Shahid Haroon M. , Andalib Iman , Alkhiari Resheed , Gaidhane Monica , Kedia Prashant , Nieto Jose , Kumta Nikhil A. , Dixon Rebekah E. , Salameh Habeeb , Mavrogenis Georgios , Bassioukas Stefanos , Abe Seiichiro , Arentes Vitor N. , Morita Flavio H. , Sakai Paulo , de Moura Eduardo G. 
Published: August 2022

Abstract
Background and study aims Endoscopic techniques are rapidly emerging for resection of subepithelial tumors (SETs). Submucosal tunneling for endoscopic resection (STER), endoscopic full-thickness resection (EFTR) and laparoscopic endoscopic cooperative surgery (LECS) are current alternatives to open surgery. In this study, we aimed to compare the three endoscopic techniques.
Patients and methods Consecutive patients who underwent resection of a submucosal esophageal or gastric lesion at several tertiary care centers were included in a dedicated registry over 3 years. Demographics, size and location of resected lesion, histology of specimen, length of procedure, adverse events (AEs), duration of hospital stay, and follow-up data were collected.
Results Ninety-six patients were included (47.7 % male, mean age 62): STER n = 34, EFTR n = 34, LECS n = 280. The lesions included leiomyoma, gastrointestinal stromal tumors (GISTs) and other. The mean lesion size was 28 mm (STD 16, range 20–72 mm). The majority of lesions in the EFTR and laparoscopic-assisted resection group were GISTs. There was no significant difference in clear resection margins, post-procedure complication rates, recurrence rate and total follow-up duration between the groups. However, the LECS group had a procedure time at least 30 minutes longer than STER or EFTR (P < 0.01). Total hospital stay for the laparoscopic-assisted resection group was also longer when compared to STER (1.5) and EFTR (1.8) (P < 0.01).
Conclusions STER, EFTR, and laparoscopic-assisted resection are efficacious approaches for resection of SETs with similar R0 resection rates, complication rates, and AE rates. Laparoscopic assisted resection appears more time-consuming and is associated with a longer hospital stay.
Optimization of Methyl Anthranilate Synthesis Process by Response Surface Methodology and Its Reaction Mechanism
Authors: Du Lei , Wang Ben , Diao Yanwei , Yuan Jinqiu , Zhang Fuyue , Zhou Haoyu 
Published: August 2022

AbstractIn this paper, a unique process for the production of methyl anthranilate (MA) was investigated. The factors of the phthalimide/sodium hypochlorite/methanol molar ratio, reaction temperature, hydrolysis temperature, and water consumption on the yield and purity of MA were analyzed. Response surface methodology (RSM) was used to optimize conditions for the semi-batch synthesis process of MA. The best synthetic conditions for the formation of MA were reaction temperature 0.5 °C, hydrolysis temperature 70 °C and n(phthalimide)/n(sodium hypochlorite)/n(methanol) = 1:2.03:5.87, and water consumption m(H2O)/m(phthalimide) = 7.16:1. The yield of MA could reach 90% under the optimal conditions, which is more than 10% higher than that of the previous semi-batch process. Furthermore, the reaction mechanism was investigated by infrared spectroscopy analysis, and the mechanism of ester group formation and the structure of intermediate products are proposed. The byproduct of the reaction was studied by GC-MS analysis, a byproduct called 2-cyanobenzoic acid has been discovered. Therefore, an unprecedented reaction mechanism of the whole synthesis process is proposed.
The future of education utilizing artificial intelligence in Turkey
Authors: İçen Mustafa 
Published: August 2022

AbstractThis study examined the potential effects of artificial intelligence on Turkish education. A qualitative research approach was employed by posing an open-ended question to academics in order to attain this objective thanks to built-in capabilities for conducting complicated computer operations, cloud-based services, and conciliatory accession for agile network connections. This study emphasizes that Turkey is highly fragmented and consists of various business organizations at both the municipal and regional levels. The two main policy documents produced by the Turkish government suggest that colleges play a strong role in national and regional Artificial Intelligence (AI) strategies for workforce growth, with substantial consequences for AI adoption strategies. These documents include information on three well-known educational entities: The new oriental workgroups, recurrent neural networks, and classroom clustering. Significant aspects of Turkey’s educational AI growth include a strong private education industry and a growing international interest. The investigation results revealed a decline in the level of understanding regarding the methods of using artificial intelligence, indicating the necessity for additional awareness-raising in Turkey.
Thermal transport in 3D printed shape memory polymer metamaterials
Authors: Farzinazar Shiva , Wang Yueping , Abdol-Hamid Owens Charles , Yang Chen , Lee Howon , Lee Jaeho 
Published: August 2022

Shape memory polymers are gaining significant interest as one of the major constituent materials for the emerging field of 4D printing. While 3D-printed metamaterials with shape memory polymers show unique thermomechanical behaviors, their thermal transport properties have received relatively little attention. Here, we show that thermal transport in 3D-printed shape memory polymers strongly depends on the shape, solid volume fraction, and temperature and that thermal radiation plays a critical role. Our infrared thermography measurements reveal thermal transport mechanisms of shape memory polymers in varying shapes from bulk to octet-truss and Kelvin-foam microlattices with volume fractions of 4%–7% and over a temperature range of 30–130 °C. The thermal conductivity of bulk shape memory polymers increases from 0.24 to 0.31 W m−1 K−1 around the glass transition temperature, in which the primary mechanism is the phase-dependent change in thermal conduction. On the contrary, thermal radiation dominates heat transfer in microlattices and its contribution to the Kelvin-foam structure ranges from 68% to 83% and to the octet-truss structure ranges from 59% to 76% over the same temperature range. We attribute this significant role of thermal radiation to the unique combination of a high infrared emissivity and a high surface-to-volume ratio in the shape memory polymer microlattices. Our work also presents an effective medium approach to explain the experimental results and model thermal transport properties with varying shapes, volume fractions, and temperatures. These findings provide new insights into understanding thermal transport mechanisms in 4D-printed shape memory polymers and exploring the design space of thermomechanical metamaterials.
The translator as rereader
Authors: Ray Sohomjit 
Published: August 2022

AbstractA. K. Ramanujan’s complicated invocations of fidelity in the paratexts of his pioneering translations have invited analyses that focus on contradictions and paradoxes in his translation theory and practice. Providing a brief historical overview of translation in the South Asian context, this article contextualizes fidelity as a colonial remnant produced due to Ramanujan’s need to move between two disparate models of translation. Emphasizing Ramanujan’s identity as a poet-translator, I claim that his translation practice should be seen to have a poetics of its own; the impression of contradiction or paradox is resolved and the colonial remnant of fidelity decentralized if we consider this poetics to be a deeply hermeneutic act. I describe Ramanujan’s translation poetics to be defined by rereading, such that the translator is not just a reader nor fully a writer, but one who straddles both roles with ease to exist in community with other readers.
Pressure induced structural phase transition in Cr doped Mn2O3 multiferroics
Authors: Chandra Mohit , Yadav Satish , Srihari Velaga , Poswal Himanshu Kumar , Rawat Rajeev , Singh Kiran 
Published: August 2022

Abstract
The pressure dependent structural properties of polycrystalline Mn2−xCrxO3 (x = 0, 0.01, 0.05) multiferroics have been investigated using synchrotron x-ray diffraction (SXRD) measurements up to 41 GPa at room temperature (RT). Our results illustrate that irrespective of their RT crystal structure, all the studied samples undergo pressure induced structural phase transition to monoclinic phase. For pristine Mn2O3, the phase transition starts around 20.8 GPa and completely transformed to monoclinic phase around 37 GPa during compression. The co-existence of orthorhombic and monoclinic phase persists at wide pressure range i.e. 20.8 to 37 GPa. The Cr substitutions lower the required pressure for pressure induced phase transition i.e. for x = 0.01 and x = 0.05, Cr doped samples, the pressure induced phase transition occurs at 35 GPa and 33 GPa, respectively. These transitions are reversible (with hysteresis) during decompression and remained unquenchable under pressure. These results corroborate that Cr substitution modify the RT crystal structure and induces positive chemical pressure in Mn2O3.