bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production performance, egg quality and some blood parameters of heat‐stressed laying hens as affected by dietary supplemental Vit B6, Mg and Zn
Authors: Gholizadeh Hossein , Torki Mehran , Mohammadi Hamed 
Published: January 2022

AbstractObjectivesThe effects of dietary supplements, including magnesium sulfate (Mg), zinc oxide (Zn) and vitamin B6 (Vit B6), on the performance of laying hens reared under normal (NC) and heat‐stress (HSC) conditions were investigated.Material and MethodsA total of 288 30‐week‐old Lohmann LSL‐Lite laying hens were randomly divided into 48 cages and assigned to receive one of the eight diets with six replicates and six hens per replicate, based on a 2 × 2 × 2 factorial arrangement of treatments. Dietary supplements, including two levels (0 & 600 mg/kg) of Mg, two levels (0 & 30 mg/kg) of Zn and two levels (0 & 8 mg/kg) of Vit B6, in normal and heat‐stress conditions, were tested at 30–40 and 41–45 weeks of age, respectively.ResultsIn the Vit B6 group, a decrease in feed intake (FI), egg production (EP), albumin, Zn, Fe and Mg, and an increase in triglyceride and insulin in HSC were observed, in addition to a decrease in cholesterol and an increase in egg weight (EW) in NC. Supplemental Mg decreased EP, blood triglycerides and copper in NC, and Zn, Fe and Mg in HSC as well. Feeding Zn, increased egg shape index, total protein and copper in addition to yolk index in NC and Fe in HSC. EWs were higher in hens supplemented with Vit B6+Mg in HSC. Increased insulin and decreased glutathione peroxidase activity were detected with the Vit B6+Zn compared to feeding either Vit B6 or Zn in HSC.ConclusionsThe results indicated Vit B6 could improve EWs and suppress blood cholesterol in NC. Zn improved the egg shape index in NC.
God’s Work in the World: The Deep Compatibility of Real Liberalism with Any Abrahamic Religion
Authors: McCloskey Deirdre Nansen 
Published: January 2022

AbstractI propose, in brief, an intimate, perhaps desirable, but anyway necessary, connection between free will in Abrahamic theology and free action in liberal ideology. The economy, its work, its consumption, even its banking, are not inconsistent with a Christian life if achieved by free will. That is to say, contrary to a century-long supposition among theologians and their enemies, belief in a just and loving God does not entail socialism. The Christian gospels and many a Christian theologian attack wealth, surprisingly harshly by the standards of the rest of the world’s religious canon. It is not surprising, therefore, that in the nineteenth century, a bourgeois but Christian Europe invented the idea of socialism. But statism is by no means necessary for a Christian community. I gesture here towards a much longer case made earlier and recently by me and other Christian admirers of commercially tested betterment. The great liberal era was brief, from 1776 to 1848. It established freedom of religion. But freedom is freedom is freedom. A free-willed person should be, in God’s eyes, free from human interference in religion and behavior and business.
On discrete anomalies in chiral gauge theories
Authors: Smith Philip Boyle , Karasik Avner , Lohitsiri Nakarin , Tong David 
Published: January 2022

Abstract
We study two well-known SU(N) chiral gauge theories with fermions in the symmetric, anti-symmetric and fundamental representations. We give a detailed description of the global symmetry, including various discrete quotients. Recent work argues that these theories exhibit a subtle mod 2 anomaly, ruling out certain phases in which the theories confine without breaking their global symmetry, leaving a gapless composite fermion in the infra-red. We point out that no such anomaly exists. We further exhibit an explicit path to the gapless fermion phase, showing that there is no kinematic obstruction to realising these phases.
Perturbatively exact w1+∞ asymptotic symmetry of quantum self-dual gravity
Authors: Ball Adam , Narayanan Sruthi A. , Salzer Jakob , Strominger Andrew 
Published: January 2022

Abstract
The infinite tower of positive-helicity soft gravitons in any minimally coupled, tree-level, asymptotically flat four-dimensional (4D) gravity was recently shown to generate a w1+∞ asymptotic symmetry algebra. It is natural to ask whether this classical algebra acquires quantum corrections at loop level. We explore this in quantum self-dual gravity, whose amplitudes acquire known one-loop exact all-plus helicity quantum corrections. We show using collinear splitting formulae that, remarkably, the w1+∞ algebra persists in quantum self-dual gravity without corrections.
Disturbed lipid and amino acid metabolisms in COVID-19 patients
Authors: Masoodi Mojgan , Peschka Manuela , Schmiedel Stefan , Haddad Munif , Frye Maike , Maas Coen , Lohse Ansgar , Huber Samuel , Kirchhof Paulus , Nofer Jerzy-Roch , Renné Thomas 
Published: January 2022

AbstractThe Coronavirus disease 2019 (COVID-19) pandemic is overwhelming the healthcare systems. Identification of systemic reactions underlying COVID-19 will lead to new biomarkers and therapeutic targets for monitoring and early intervention in this viral infection. We performed targeted metabolomics covering up to 630 metabolites within several key metabolic pathways in plasma samples of 20 hospitalized COVID-19 patients and 37 matched controls. Plasma metabolic signatures specifically differentiated severe COVID-19 from control patients. The identified metabolic signatures indicated distinct alterations in both lipid and amino acid metabolisms in COVID-19 compared to control patient plasma. Systems biology-based analyses identified sphingolipid, tryptophan, tyrosine, glutamine, arginine, and arachidonic acid metabolism as mostly impacted pathways in COVID-19 patients. Notably, gamma-aminobutyric acid (GABA) was significantly reduced in COVID-19 patients and GABA plasma levels allowed for stratification of COVID-19 patients with high sensitivity and specificity. The data reveal large metabolic disturbances in COVID-19 patients and suggest use of GABA as potential biomarker and therapeutic target for the infection.
Artificial intelligence ELSI score for science and technology: a comparison between Japan and the US
Authors: Hartwig Tilman , Ikkatai Yuko , Takanashi Naohiro , Yokoyama Hiromi M. 
Published: January 2022

AbstractArtificial intelligence (AI) has become indispensable in our lives. The development of a quantitative scale for AI ethics is necessary for a better understanding of public attitudes toward AI research ethics and to advance the discussion on using AI within society. For this study, we developed an AI ethics scale based on AI-specific scenarios. We investigated public attitudes toward AI ethics in Japan and the US using online questionnaires. We designed a test set using four dilemma scenarios and questionnaire items based on a theoretical framework for ethics, legal, and social issues (ELSI). We found that country and age are the most informative sociodemographic categories for predicting attitudes for AI ethics. Our proposed scale, which consists of 13 questions, can be reduced to only three, covering ethics, tradition, and policies. This new AI ethics scale will help to quantify how AI research is accepted in society and which area of ELSI people are most concerned with.
Feral ungulate and macropod responses to resource scarcity and predation risk at savanna waterholes
Authors: Mihailou Helenna , Nimmo Dale G. , Massaro Melanie 
Published: January 2022

Abstract
When exotic species are introduced to new environments, they often have a competitive advantage over native species. In northern Australia, pigs, cattle, and water buffalo have established widespread, feral populations. As ungulates have high water requirements, they typically congregate near waterpoints. We used a fencing experiment to test whether native macropods preferentially visited savanna waterholes where large ungulates were excluded. We also investigated whether water scarcity affected the visitation behaviour and temporal activity patterns of herbivores at waterholes and whether increasing prey aggregation at waterholes increased dingo presence. We found that macropods did not use fenced waterholes preferentially over unfenced ones. Cattle presence at waterholes increased as water became scarce, while macropod and pig presence peaked in the middle of the dry season. Macropod activity declined rapidly at the end of the dry season when cattle activity was greatest, suggesting that macropods may avoid waterholes in areas utilised by cattle when competition for resources is high. Macropods and all ungulates visited waterholes more during a drought year compared to an average rainfall year. Despite increasing prey activity, dingo presence at waterholes did not increase when water became scarce. However, dingo presence increased significantly on moonless nights. Our results suggest that competition between macropods and ungulates may intensify during periods of water scarcity. Climate change and pastoral intensification are likely to increase competition for resources between ungulates and macropods in Australian savannas, potentially threatening macropod populations across the landscape in the future.

Significance statement
In northern Australia, feral populations of pigs, cattle, and water buffalo compete with native wildlife for access to water sources. As interspecific competition favours species with a size advantage, we tested whether kangaroos and wallabies (macropods) preferentially use waterholes where large ungulates (cattle and buffalo) were excluded. We found that macropods avoided waterholes when cattle presence was high but did not preferentially use waterholes where livestock were excluded. When water scarcity peaked during a drought, macropods and all three feral ungulate species visited waterholes more. However, increased prey presence at waterholes during the drought did not correspond with increased predator (dingo) presence. Our study advances the understanding of behavioural interactions between invasive and native species at important shared resources, and how this may affect wildlife conservation in an increasingly unpredictable environment.
Long-term cost-effectiveness of matrix-associated chondrocyte implantation in the German health care system: a discrete event simulation
Authors: Vogelmann Tobias , Roessler Philip P. , Buhs Matthias , Ostermeier Sven , Gille Justus , Hoburg Arnd , Zöllner York , Schwarz Sebastian , Schubert Tino , Grebe Marco , Zinser Wolfgang 
Published: January 2022

Abstract
Introduction
Cartilage defects in the knee can be caused by injury, various types of arthritis, or degeneration. As a long-term consequence of cartilage defects, osteoarthritis can develop over time, often leading to the need for a total knee replacement (TKR). The treatment alternatives of chondral defects include, among others, microfracture, and matrix-associated autologous chondrocyte implantation (M-ACI). The purpose of this study was to determine cost-effectiveness of M-ACI in Germany with available mid- and long-term outcome data, with special focus on the avoidance of TKR.

Materials and methods
We developed a discrete-event simulation (DES) that follows up individuals with cartilage defects of the knee over their lifetimes. The DES was conducted with a status-quo scenario in which M-ACI is available and a comparison scenario with no M-ACI available. The model included 10,000 patients with articular cartilage defects. We assumed Weibull distributions for short- and long-term effects for implant failures. Model outcomes were costs, number of TKRs, and quality-adjusted life years (QALYs). All analyses were performed from the perspective of the German statutory health insurance.

Results
The majority of patients was under 45 years old, with defect sizes between 2 and 7 cm2 (mean: 4.5 cm2); average modeled lifetime was 48 years. In the scenario without M-ACI, 26.4% of patients required a TKR over their lifetime. In the M-ACI scenario, this was the case in only 5.5% of cases. Thus, in the modeled cohort of 10,000 patients, 2700 TKRs, including revisions, could be avoided. Patients treated with M-ACI experienced improved quality of life (22.53 vs. 21.21 QALYs) at higher treatment-related costs (18,589 vs. 14,134 € /patient) compared to those treated without M-ACI, yielding an incremental cost‐effectiveness ratio (ICER) of 3376 € /QALY.

Conclusion
M-ACI is projected to be a highly cost‐effective treatment for chondral defects of the knee in the German healthcare setting.
Locking suture repair versus ligament augmentation—a biomechanical study regarding the treatment of acute lateral collateral ligament injuries of the elbow
Authors: Ott Nadine , Harland Arne , Lanzerath Fabian , Leschinger Tim , Hackl Michael , Wegmann Kilian , Müller Lars Peter 
Published: January 2022

Abstract
Background
Lateral collateral ligament (LCL) tears are frequently observed in fractures and dislocations of the elbow. Recent biomechanical evidence suggests that additional ligament augmentation may improve repair stability. The aim of this biomechanical in-vitro study was to compare the resistance of a locking suture repair of the LCL with a ligament augmentation technique.

Material and methods
Eight fresh frozen cadaveric elbows were evaluated for stability against varus/posterolateral rotatory forces (3 Nm). A strain gauge (µm/m; negative values) was placed at the origin and insertion of the lateral ulnar collateral ligament (LUCL) and cyclic loading was performed for 1000 cycles. We analyzed three distinct scenarios: (A) native LCL, (B) locking transosseou suture repair of the LCL, (C) simple LCL repair with additional ligament augmentation of the LUCL.

Results
The mean measured strain was − 416.1 µm/m (A), − 618 µm/m (B) and − 288.5 µm/m (C) with the elbow flexion at 90°; the strain was significantly higher in scenario B compared to C (p = .01). During the cyclic load (1000) the mean measured strain was − 523.1 µm/m (B) and − 226.3 µm/m (C) with the elbow flexion at 60°; the strain was significantly higher in scenario B compared to C (p = .01). No significant difference between the first and the last cycles was observed (p = .09; p = .07). One failure of the LCL repair was observed after 1000 cycles; none of the ligament augmentations failed.

Conclusion
Ligament augmentation (C) provides higher resistance compared to the native LCL (A) and to the locking suture repair technique (B). Both techniques, however, hold up during 1000 cycles. While ligament augmentation might enhance the primary stability of the repair, future clinical studies have to show whether this increase in resistance leads to negative effects like higher rates of posttraumatic elbow stiffness.

Level of evidence
Basic science study, biomechanics.
Socioeconomic disparities in endometrial cancer survival in Germany: a survival analysis using population-based cancer registry data
Authors: Bedir Ahmed , Abera Semaw Ferede , Vordermark Dirk , Medenwald Daniel 
Published: January 2022

Abstract
Purpose
Area-based socioeconomic deprivation has been established as an important indicator of health and a potential predictor of survival. In this study, we aimed to measure the effect of socioeconomic inequality on endometrial cancer survival.

Methods
Population-based data on patients diagnosed with endometrial cancer between 2004 and 2014 were obtained from the German Centre for Cancer Registry Data. Socioeconomic inequality was defined by the German Index of Socioeconomic Deprivation. We investigated the association of deprivation and overall survival through Kaplan–Meier curves and Cox proportional regression models.

Results
A total of 21,602 women, with a mean age of 67.8 years, were included in our analysis. The observed 5-year overall survival time for endometrial cancer patients living in the most affluent districts (first quintile) was 78.6%. The overall survival rate decreased as the level of deprivation increased (77.2%, 73.9%, 76.1%, 74.7%, for patients in the second, third, fourth, and fifth quintile (most deprived patients), respectively). Cox regression models showed stage I patients living in the most deprived districts to have a higher hazard of overall mortality when compared to the cases living in the most affluent districts [Hazard ratio: 1.20; 95% Confidence interval (0.99–1.47)] after adjusting for age, tumor characteristics, and treatment.

Conclusion
Our results indicate differences in endometrial cancer survival according to socioeconomic deprivation among stage I patients. Considering data limitations, future studies with access to individual-level patient information should be conducted to examine the underlying causes for the observed disparity in cancer survival.
Trends in drought occurrence and severity at mid-latitude European stations (1951–2015) estimated using standardized precipitation (SPI) and precipitation and evapotranspiration (SPEI) indices
Authors: Dukat Paulina , Bednorz Ewa , Ziemblińska Klaudia , Urbaniak Marek 
Published: January 2022

AbstractOne of the negative consequences of climate change is the also increase in the severity, frequency and length of droughts appearing in Europe. The effects of meteorological drought are often substantial, not only for the natural environment but also for humans. Hence, the main purpose of this research was to determine the trends in the severity and occurrence of droughts in Europe during the period 1951–2015 using the standardized precipitation index and the standardized precipitation and evapotranspiration index (SPEI). For six European sites located in mid latitudes, the number of dry months was determined and the trend of their occurrence was examined. Moreover, for the summer months in which the indicators fell below 0, the trend related to the severity of the drought was determined for each site. Despite the absence of a statistically significant trend of an increase in the occurrence of dry months in general, an increase in the severity of droughts occurring in summer was observed for the SPEI over a 6-month scale for all the investigated stations. The highest number of dry months since the 1970s appeared during the last 5 years of analysis.
Simultaneous mass spectrometry analysis of cisplatin with oligonucleotide-peptide mixtures: implications for the mechanism of action
Authors: Mansouri Farangis , Patiny Luc , Ortiz Daniel , Menin Laure , Davey Curtis A. , Mohammadi Fakhrossadat , Dyson Paul J. 
Published: January 2022

AbstractAlthough genomic DNA is the primary target of anticancer platinum-based drugs, interactions with proteins also play a significant role in their overall activity. In this study, competitive binding of cisplatin with an oligonucleotide and two peptides corresponding to segments of H2A and H2B histone proteins was investigated by mass spectrometry. Following the determination of the cisplatin binding sites on the oligonucleotide and peptides by tandem mass spectrometry, competitive binding was studied and transfer of platinum fragments from the platinated peptides to the oligonucleotide explored. In conjunction with previous studies on the nucleosome, the results suggest that all four of the abundant histone proteins serve as a platinum drug reservoir in the cell nucleus, providing an adduct pool that can be ultimately transferred to the DNA.
Graphical abstract
Adoptive parents’ finances and employment status: a 5-year longitudinal study
Authors: Paine Amy L. , Fahey Kevin , Thompson Rebecca , Shelton Katherine H. 
Published: January 2022

AbstractWe investigated risk and facilitating factors related to families’ change in finances and employment over 5 years following adoption of a child from local authority care in a prospective, longitudinal study of children placed for adoption between 2014 and 2015 (N = 96). Parents completed questionnaires at approximately 5, 21, 36, 48 and 60 months post-placement. We used time series analysis to examine the impact of child (e.g. pre-placement experiences, mental health), family structure (e.g. number of siblings, parent relationship status), and parent (e.g. mental health) factors on change in household income and parent employment status after adoption. We also examined the tendency for parents to comment on employment and finances and the emotional valence of their comments to gauge their concern about their circumstances. Children’s mental health problems were associated with primary caregivers reducing their time spent in employment and parents’ tendency to comment on their financial and work circumstances. Children who experienced more moves in care were more likely to have a primary caregiver not in full-time work, as were children with higher prosocial behaviour scores. Being in full-time work was associated with parents’ symptoms of anxiety. We also detected associations between structural features of the family and changes in income and employment. This study represents one of the first empirical investigations of factors associated with the socioeconomic features of adoptive families’ lives and informs ongoing discussion regarding the support needs of families and the timing, nature, and delivery of post-adoption professional services.
Projections of indices of daily temperature and precipitation based on bias-adjusted CORDEX-Africa regional climate model simulations
Authors: Dosio Alessandro , Lennard Christopher , Spinoni Jonathan 
Published: January 2022

AbstractWe present a dataset of daily, bias-adjusted temperature and precipitation projections for continental Africa based on a large ensemble of regional climate model simulations, which can be useful for climate change impact studies in several sectors. We provide guidance on the benefits and caveats of using the dataset by investigating the effect of bias-adjustment on impact-relevant indices (both their future absolute value and change). Extreme threshold-based temperature indices show large differences between original and bias-adjusted values at the end of the century due to the general underestimation of temperature in the present climate. These results indicate that when biases are accounted for, projected risks of extreme temperature-related hazards are higher than previously found, with possible consequences for the planning of adaptation measures. Bias-adjusted results for precipitation indices are usually consistent with the original results, with the median change preserved for most regions and indices. The interquartile and full range of the original model ensemble is usually well preserved by bias-adjustment, with the exception of maximum daily precipitation, whose range is usually greatly reduced by the bias-adjustment. This is due to the poor simulation and extremely large model range for this index over the reference period; when the bias is reduced, most models converge in projecting a similar change. Finally, we provide a methodology to select a small subset of simulations that preserves the overall uncertainty in the future projections of the large model ensemble. This result can be useful in practical applications when process-based impact models are too expensive to be run with the full ensemble of model simulations.
Novel insights on GM1 and Parkinson's disease: A critical review
Authors: Fazzari Maria , Di Biase Erika , Lunghi Giulia , Mauri Laura , Chiricozzi Elena , Sonnino Sandro 
Published: January 2022

AbstractGM1 is a crucial component of neuronal membrane residing both in the soma and nerve terminals. As reported in Parkinson’s disease patients, the reduction of GM1 determines the failure of fundamental functional processes leading to cumulative cell distress up to neuron death. This review reports on the role of GM1 in the pathogenesis of the disease, illustrating the current data available but also hypotheses on the additional mechanisms in which GM1 could be involved and which require further study. In the manuscript we discuss these points trying to explain the role of diminished content of brain GM1, particularly in the nigro-striatal system, in Parkinson’s disease etiology and progression.