bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of platelet rich plasma in knee joint pain
Authors: Thursina Cempaka , Hidayati Hanik Badriyah , Yudiyanta Yudiyanta , Pranowo Irfan , Puspamaniar Vania Ayu 
Published: June 2022

Osteoarthritis (OA) is a joint disorder is common worldwide. Pain and loss of function are the main clinical sign in knee joint OA that could come from periosteal nerve stretches, intraosseal hypertension, joint capsule stretches, intra-articular hypertension, ligament stretches, subchondral bone micro fracture, bursitis, and muscle spasm. Current therapy approach focuses on preventing progression and reducing symptoms by using a non-invasive procedure. Non-operative therapeutic intervention, that involves intra-articular injection in the knee joints, plays an important role in OA management.
Platelet rich plasma (PRP) is a plasma fraction that contains concentrated platelets, has an autologue growth factor and high concentration of proteins that could improve healing process at cellular, tendon, ligament, muscle, as well as bone related tissue injury. Growth factor contained in PRP is responsible for anti-inflammatory effect through its inhibitory effect on Nuclear factor-kB (NFkB) cascade, thus it inhibits the inflammatory mediator production along with decreased COX2 expression.
Roles of PRP towards NFkB deactivation could decrease chondrocyte inflammation, restore anabolic activity, and inhibit monocyte migration that could prevent OA progressivisity and reduce pain. PRP pathophysiology mechanism in healing process has made PRP an option for pain management in knee joint OA.
Abbreviations: OA- Osteoarthritis; PRP - Platelet rich plasma; NFkB - Nuclear factor-kB; COX2 - Cyclooxygenase-2; HGF – Hepatocyte growth factor; TGF-β - Transforming growth factor-β; IGF - Insulin-like growth factor; PDGF - Platelet-derived growth factor; FGF - Fibroblast growth factor; EGF - Epidermal growth factor; VEGF - Vascular endothelial growth factor
Key words: Osteoarthritis knee joint; Platelet rich plasma; Nuclear factor-κB (NFkB); Human; Medicine
Citation: Thursina C, Hidayati HB, Yudiyanta, Pranowo I, Puspamaniar VA. The role of platelet rich plasma in knee joint pain. Anaesth. pain intensive care 2022;26(3):405-409. DOI: 10.35975/apic.v26i3.1906
Received: November 23, 2021, Reviewed: February 12, 2022, Accepted: February 28, 2022
PERENCANAAN PEMBANGUNAN JALAN RABAT BETON UNTUK MENUJU KELOKASI CANDI DESA PATAAN KABUPATEN LAMONGAN
Authors: Rasio Hepiyanto  
Published: June 2022

Jalan merupakan sarana transportasi yang utama dalam kehidupan sehari-hari. Transportasi terbagi menjadi 3 bagian, yaitu transportasi darat, laut dan udara. Masyarakat sangatlah membutuhkan sarana dalam transportasi, karena dengan transportasi maka akan memudahkan dalam meningkatkan penghasilan masyarakat dan dapat meningkatkan ekonomi dalam suatu daerah, baik oleh masyarakat itu sendiri maupun dapat menambah penghasilan terhadap suatu desa. Di desa pataan Kabupaten Lamongan terdapat sebuah candi yang peninggalan dari raja Airlangga. Untuk menuju candi tersebut warga atau masyarakat, maupun orang dari luar kota harus menempuh jalan kaki dan jalan tersbut sangatlah naik turun. Jalan apabila musim hujan maka akan sangat sulit dilalui. Maka dibutuhkan perencanaan jalan untuk membangun sebuah jalan. Jalan beton adalah jalan untuk menuju ke lokasi candi, karena dengan kondisi tanah di Lamongan yang bergerak maka dibutukan Jalan dengan type atau model Jalan beton. Perencanaan Jalan beton harus direncanakan DED, dan RAB terlebih dahulu. Perhitungan dari RAB menunjukan Pekerjaan jalan beton untuk menuju candi di desa Pataan membutuhkan anggaran biaya untuk pekerjaannya sebesar Rp. 137.800.000,- (Seratus Tiga Puluh Tujuh Juta Delapan Ratus Ribu Rupiah).
Kata kunci: Jalan, Beton, Candi, Analisa
GENETIC VARIABILITY IN THE PRNCR1 GENE AMONG A SAMPLE OF IRAQI PROSTATE CANCER PATIENTS
Authors: Kadhim R.I. , Salman E. D. 
Published: June 2022

The PRNCR1 gene variant among sample of Prostate Cancer (PCa) Iraqi patients case-control study was used, with PCa patients (n=32) and healthy individual control (n=33). It was successfully identified two SNPs in prostate cancer-associated noncoding RNA-1 (PRNCR-1) gene by using PCR technique and direct sequencing . The first SNP is rs13252298 (A>G) have three genotypes (AA,AG,GG )and the second SNP is rs5013678 (T> C) have three genotypes TT,TC,CC),these genotype frequencies were not in agreement with Hardy-Weinberg Equilibrium (HWE) in patients and controls .It was observed that AG genotype was more frequent in patients than controls(68.7% vs. 36.4%) with significant difference p<0.01 ,and the estimated OR of such a difference was 3.85 , this value was positive associated with PCa patients that mean this genotype AG was risk factor for PCa patients, it was also noticed that G allele in PCa patients compared with controls(40.6 vs.33.3%) show not significant difference p>0.05 . It was revealed that G allele have OR=1.16 that mean this allele have positive risk factor for PCa patients . In conclusion AG genotype for SNP rs13252298 was associated with PCa patients.
EFFECTS OF PROBIOTIC, PREBIOTIC AND SYMBIOTIC ON BROILER BREEDER PERFORMANCE, EGG PRODUCTION AT DIFFERENT STOCK DENSITY
Authors: AZIZ H. I. , AL-Hawezy D.J. 
Published: June 2022

This study was aimed to investigat the effects of probiotic, prebiotic and symbiotic on the egg production, suitable egg, unsuitable egg and uniformity reread at deferent stock density. A total of 600 broiler breeder Ross 308 (540 female and 60 male) was used in this study for a period of 48 -64 weeks at two levels of stocking density (normal and high stock density). For each stock density birds were fed diet either control diet (T1), standard diet + 0.15g probiotic (Lactobacillus acidophilus, Bacillus subtilis, Bifidobacterium, Saccharomyces cervisiae) powder/ kg diet (T2), standard diet + 0.15g prebiotic (inulin) powder/ kg diet(T3) and standard diet + 0.15g symbiotic (Lactobacillus acidophilus, Bacillus subtilis, Bifidobacterium, Saccharomyces cervisiae+inulin) powder/ kg diet (T4). Highly significant increase in egg production and suitable egg for dietary additives compared with control group at all weeks of production, but dietary probiotic had significant decrease in unsuitable egg when compared with the controls, however normal density significant increases in egg production and unsuitable egg compared with high density. The probiotic treatments had the lowest body weight variation. It can be concluded that the supplementation of probiotic in the diet of commercial broiler breeder reared under high stocking density had a positive influence on overall suitable egg.
Dataset Quality Assessment with Permutation Testing Showcased on Network Traffic Datasets
Authors: Wasielewska Katarzyna , Soukup Dominik , Čejka Tomáš , Camacho Jose 
Published: June 2022

<p>Intelligent and autonomous networks require precise and fast mechanisms that ensure error-free and efficient operation. Modern solutions are increasingly based on artificial intelligence, in particular on machine learning, to reliably process huge amounts of data. Therefore, high-quality datasets are essential to train machine learning models. Unfortunately, the problem of assessing the quality of datasets is very challenging and often overlooked. This paper proposes a method for assessing the dataset quality in the context of binary classification. It is based on permutation testing and examines the strength of the relationship between observations and labels. Experiments carried out on simulated and real network datasets show that the method is sensitive to detect errors/mislabels in the labeled dataset. We also present theoretical considerations justifying our results.</p>
Enhancing active reconfigurable intelligent surface
Authors: Khalil Muhammad 
Published: June 2022

<p> A Reconfigurable Intelligent Surface (RIS) panel comprises many independent Reflective Elements (REs). One possible way to implement an RIS is to use a binary passive load impedance connected to an antenna element to achieve the modulation of reflected radio waves. Each RE reflects incoming waves (incident signal) by using on/off modulation between two passive loads and adjusting its phase using a Phase Shifter (PS). However, this modulation process reduces the amplitude of the reflected output signal to less than unity. Therefore, recent RIS works have employed Reflection Amplifiers (RAs) to compensate for the losses incurred during the modulation process. However, these systems only improve the reflection coefficient for a single modulation state, resulting in suboptimal RE efficacy. Thus, this paper proposes a strategy for optimising RE by continuously activating the RA regardless of the switching load state. The performance of the proposed scheme is evaluated in two scenarios: (1) In the first scenario (Sc1), the RA only operates to compensate for high-impedance loads, and (2) in the second scenario (Sc2), the RA runs continuously regardless of the RE loads. To benchmark the performance of Sc1 and Sc2, various metrics are compared, including signal-to-noise ratio, insertion loss, noise figure, communication range, and power-added efficiency. Numerical examples are provided to demonstrate the effectiveness of the proposed scheme. It is found that the proposed system in Sc2 leads to better overall performance compared to Sc1 due to the increased gain of the RIS reflection.</p>
Adaptive STDP-based On-chip Spike Pattern Detection
Authors: Gautam Ashish , Kohno Takashi 
Published: June 2022

<p>In this study, we solved a noisy spatiotemporal spike pattern detection task on an analog neuromorphic chip using an unsupervised learning rule. Spike-timing-dependent plasticity (STDP) is the most widespread unsupervised learning rule implemented in Spiking Neural Networks (SNNs) and neuromorphic chips. It has been shown to perform well in conventional benchmark tasks such as spike pattern classification and image classification in SNN simulations. However, a significant performance gap exists between its ideal model simulation and neuromorphic implementation. The learning rate of STDP learning depends on the resolution of synaptic efficacy, high resolution efficacy leads to a small learning rate and stable performance. In computer simulation, synaptic efficacy is configured using 64-bit floating-point precision whereas in low-power neuromorphic chips the resolution is generally restricted to under 5-bit fixed point precision due to silicon area and power constraints. This leads to a degradation in the performance. To solve this problem we proposed a bioinspired learning rule named adaptive STDP learning in a previous study and demonstrated via numerical simulation that the performance of adaptive STDP learning (using 4-bit fixed point synapses) is similar to STDP learning (using 64-bit floating-point precision) in a noisy spatiotemporal spike pattern detection task. In this study, we present the experimental results for the same. The experimental results are similar to those obtained in our simulation-based study. To our best knowledge, this is the first time that an unsupervised, noisy spatiotemporal spike pattern detection task has been demonstrated to perform well on a mixed-signal CMOS neuromorphic chip with low-resolution synaptic efficacy. </p>
Evaluating anti-microbial and anti-oxidative potential of red biopigment from Monascus purpureus
Authors: Chaudhary Vishu , Katyal Priya , Panwar Harsh , Puniya Anil Kumar , Poonia Anuj Kumar 
Published: June 2022

In the present study, Monascus red biopigment produced by solid-state fermentation was evaluated for its anti-microbial and antioxidative potential. The antibacterial activity through Scanning Electron Microscopy against Bacillus cereus, Escherichia coli, and Staphylococcus aureus was found to show morphological damage in some cells, as evidenced by the outflow of cell contents, deep craters, burst cells, and cell death at concentration of 200 µg/ml of biopigment. Moreover, antibacterial activity through agar well diffusion method against Bacillus cereus, Staphylococcus aureus, Klebsiella pneumonia and Pseudomonas aeruginosa was in range of 2-6 mm by varying concentration of biopigment from 1 to 20 mg/ml.Next, the antifungal activity of the extracted biopigment was in the range of 2-9 mm for Aspergillus flavus, Fusarium oxysporum and Alternaria alternata. In addition, antioxidant efficacy of red biopigment through DPPH, ABTS and FRAP assay results was found to show 59.69 %, 91.1 %, and 15.22 % free radical scavenging activity. The results of this study revealed that red biopigment has potential to modulate the antimicrobial and antioxidative activity.
PENERAPAN MODEL PEMBELAJARAN PROJECT BASED LEARNING UNTUK MENINGKATKAN HASIL BELAJAR PESERTA DIDIK TEMA 8 SUB TEMA 2 KELAS 4 SD N 1 GODONG 2022
Authors: Ren ita Nita 
Published: June 2022

The purpose of this study was to determine the results of the application of the project based learning on the learning outcomes of students in theme 8 sub-theme 2 for grade 4 SD Negeri 1 Godong. This study uses a quantitative method, with a Pre-Experimental Design Group in the form of One-Group Prettest-Posttest Design. Data collection techniques in this study were through observation, interviews, tests consisting of prettest-posttest with data analysis techniques using paired sample t-test with db N1-N2-1 and a significant level of 0.05. The results showed that the average posttest 80.6. Based on the results of the paired sample T-test was obtained that Tcount= 4.532 and Ttable= 2.037. From the results of these calculations obtained Tcount > Ttable , it can be concluded that the application of the project based learning succeeded in improving the learning outcomes of 4th grade students of SD Negeri 1 Godong. Based on the results of the research obtained, the researcher suggests that the project based learning can be used as an alternative in schools to improve student learning outcomes.
PENGEMBANGAN MEDIA KVISOFT FLIPBOOK MAKER BERBASIS PENDEKATAN SAINTIFIK PADA PEMBELAJARAN TEMATIK TERPADU DI KELAS VS D
Authors: Saralee Adelweiss , Reinita Reinita 
Published: June 2022

Penelitian ini dilatarbelakangi oleh tidak tersedianya media pembelajaran yg bervariasi dan monoton. sehingga mengakibatkan situasi belajar yg konvensional dimana pembelajaran hanya berpusat di guru saja serta siswa sekedar mendapatkan informasi. dan jua ditimbulkan kurangnya kreatifitas pengajar dalam membangun media pembelajaran yang menarik. Penelitian ini bertujuan buat membuatkan media Kvisoft Flipbook Maker berbasis pendekatan saintifik di pembelajaran tematik terpadu di kelas V Sekolah Dasar yg valid dan praktis. Jenis penelitian ini adalah pengembangan memakai model ADDIE. Produk yang dikembangkan yaitu media Kvisoft Flipbook Maker berbasis pendekatan santifik di Tema 8 (Lingkungan sahabatt Kita) subtema 1 (Manusia dan Li
Penelitian ini dilatarbelakangi oleh tidak tersedianya media pembelajaran yg bervariasi dan monoton. sehingga mengakibatkan situasi belajar yg konvensional dimana pembelajaran hanya berpusat di guru saja serta siswa sekedar mendapatkan informasi. dan jua ditimbulkan kurangnya kreatifitas pengajar dalam membangun media pembelajaran yang menarik. Penelitian ini bertujuan buat membuatkan media Kvisoft Flipbook Maker berbasis pendekatan saintifik di pembelajaran tematik terpadu di kelas V Sekolah Dasar yg valid dan praktis. Jenis penelitian ini adalah pengembangan memakai model ADDIE. Produk yang dikembangkan yaitu media Kvisoft Flipbook Maker berbasis pendekatan santifik di Tema 8 (Lingkungan sahabatt Kita) subtema 1 (Manusia dan Lingkungaan) Pembelajaran 3 dan 4. Proses validasi dinilai oleh 3 ahlidiantaranya media, materi, serta bahasa. yang akan terjadi peneitian yg dikembangkan diperoleh yang akan terjadi tingkat validitas media Kvisoft Flipbook Maker menggunakan jumlah keseluruhan nilai validasi 96% yaitu termasuk dalam tingkatan sangat valid. hasil uji coba praktikalitas di lihat angket respon siswa serta guru. Dimana angket respon siswa secara keseluruah sebanyak 10 orang adalah 97% dalam kategori sangat praktis serta angket respond guru adalah 95,7% dalam kategori sangat praktis. Dengan demikian, media Kvisoft Flipbook Maker berbasis pendekata saintifik dinyatakan valyd dan praktiIs dipergunakan dalam kegiatan pembelajaran.
ngkungaan) Pembelajaran 3 dan 4. Proses validasi dinilai oleh 3 ahlidiantaranya media, materi, serta bahasa. yang akan terjadi peneitian yg dikembangkan diperoleh yang akan terjadi tingkat validitas media Kvisoft Flipbook Maker menggunakan jumlah keseluruhan nilai validasi 96% yaitu termasuk dalam tingkatan sangat valid. hasil uji coba praktikalitas di lihat angket respon siswa serta guru. Dimana angket respon siswa secara keseluruah sebanyak 10 orang adalah 97% dalam kategori sangat praktis serta angket respond guru adalah 95,7% dalam kategori sangat praktis. Dengan demikian, media Kvisoft Flipbook Maker berbasis pendekata saintifik dinyatakan valyd dan praktiIs dipergunakan dalam kegiatan pembelajaran.
ПАТОГІСТОЛОГІЧНІ ЗМІНИ У НИРКАХ ПТИЦІ ЗА АНТИБІОТИКОТЕРАПІЇ
Authors: Ліщук С. , Добровольський В. , Каспров Р. , Пливанюк Є. 
Published: June 2022

Представлено результати гістологічного дослідження нирок птиці при тривалому використанні антибіотиків широкого спектру дії. При введенні антибіотиків у дозі 30000 і 50000 ОД/кг живої маси, на 60-й день від початку досліду, відмічаються деструктивні зміни в тканині нирок, що проявлялося частковим некрозом.
Досліджено,що хлортетрациклін в меншій, а фармазин - в більшій мірі, сприяли розвитку інтерстиціального нефрозу нирок. Установлено, що тривала антибіотикотерапія у піддослідної птиці негативно впливає на гематологічні та біохімічні показники крові, спостерігається загальне зниження імунітету та резистентності, що може бути пов’язано з напруженням у роботі серцевого м’яза за розвитку інтоксикації організму при дистрофічних процесах у печінці та нефрозі нирок.
БІОХІМІЧНІ ПОКАЗНИКИ СИРОВАТКИ КРОВІ КРОЛІВ В ПЕРІОД МІГРАЦІЇ CYSTICERCUS PISIFORMIS
Authors: Богач М. , Коваленко Л. , Горобей О. 
Published: June 2022

Однією з найактуальніших проблем за вирощування кролів є зниження їх резистентності, що зумовлено поширенням окремих інвазійних захворювань, передусім цистицеркозу, який викликається личинковою стадією Cysticercus pisiformis статевозрілої цестоди Taenia pisiformis. В період міграції Cysticercus pisiformis найбільші зміни в біохімічних показниках сироватки крові кролів відбуваються на 25-ту та 35-ту доби. Вірогідно (р˂0,001) зменшується вміст загального білка на 3,7 % і 2,6 %, альбумінів – на 27,7 % і 28,6 % та суттєво збільшується вміст β- і γ-глобулінів на 35,3 %, 28,4% і 61,8 %, 55,0 % відповідно та активність АЛТ в 2,5 і 3,5 рази, що вказує на розвиток дистрофічних процесів у печінці. Підвищення концентрації циркулюючих імунних комплексів на 40 % і серомукоїдів у 8,5 рази свідчить про супресію клітинної і гуморальної ланок імунітету хворих кролів.
Al Tadākhul Al Lughowi wa Ãtsarah ‘Ala Alta’bir Al Syafawi
Authors: Syahidah Nurul , Ridha Fahmi , Wijaya Kusumah Mada 
Published: June 2022

ملخص البحث
قام الباحث بدراسة هذ الموضوع لمعرفة التدخل التركيبي الذي يقع لدى الطالبات ومعرفة تأثيره في التعبير الشفهي وتحليله. أما نوع هذا البحث هو البحث الوصفي التحليلي. جمعت البيانات عن طريق المراقبة والملاحظة والاطلاع إلى سجلات الأخطاء اللغوية من قبل قسم اللغة للجمعية الطلابية للبنات. أما تحليل البيانات المستخدم مبني على رأي ميلس وهبرمان. فحصل الباحث على النتائج: وقوع التدخل التركيبي لدى الطالبات وله أثر سلبي مؤثر في التعبير الشفهي وهو وقوع الأخطاء التركيبية في التعبير الشفهي باللغة العربية. وذلك لأسباب التالية وهي الاعتقاد الخاطئ، والتسهل، والغفلة عن التراكيب النحوية، نقل تراكيب اللغة الأم، والاعتماد على الترجمة الإندونيسية، التراكيب صحيحة في رأيه.
الكلمات الأساسية: التدخل التركيبي؛ التعبير الشفهي، التداخل اللغوي.

Abstract
The researcher studied this topic to find out the structural disruptions that spread among the students and their impact on ta’bīr syafahī and its analysis. This research used analytical descriptive research. Data were collected by observation, and access to linguistic error recorded by Linguistic Society. The analysis of user data is based on Miles and Huberman's opinion. The researcher has obtained some results: The occurrence of structural interventions among students and a negative impact on ta’bīr syafahī, which is the occurrence of syntactic errors in ta’bīr syafahī in Arabic. This is caused by some reasons i.e misunderstanding, simplification, negligence of grammatical structures, transmission of mother tongue structures, dependency on Indonesian translation, over self confidence in making sentences.
Tasmîm Al-Al’âb Al-Lughawiyyah Li Ta’lîm Hurûf Al-Jâr Fî Barnâmij Taqwiyati Al-Lughah
Authors: Thahir Sahruni , Huda Syirojul 
Published: June 2022

ملخص البحث
تهدف هذه الدراسة إلى تصمم الألعاب اللغوية لتعليم حروف الجر في برنامج تقوية اللغة لقسم الإعداد اللغوي في جامعة الراية لتكون وسيلة تعليم حروف الجر في هذه البرنامج. يهدف هذا البحث بتصميم الألعاب اللغوية لتعليم حروف الجر في برنامج تقوية اللغة لقسم الإعداد اللغوي بجامعة الراية سوكابومي منطلقا من كفاءة الطالبات وحاجاتهن. ومدخل هذا البحث هو المدخل الكمي والكيفي وأما منهج البحث الذي تستخدمها الباحثة هو بحث الوصفي التحليلي. صممت الباحثة الألعاب اللغوية عن تعليم حروف الجر في برنامج تقوية اللغة لقسم الإعداد اللغوي بجامعة الراية سوكابومي بهذه الخطوات: تحليل الحاجات ومشكلات، وتحليل المواقف تعيين أسئلة الاستبانة، تخطيط الأهداف العامة والخاصة، واختيار الألعاب اللغوية، تعيين طرق التعليم، ترتيب محتوى الألعاب المصممة، وتقويم التعليم. أما لمعرفة مدى صلاحية الألعاب المصممة وزعت الباحثة الاستبانة إلى الخبرات للتصديق، نتائج الاستبانة من الخبيرات هي وصل إلى تقدير " جيد ". وأما نتائج الاستبانة من رئيسة التعليم للبنات بجامعة الراية وصل إلى 88%، وهذا يدل على أن الألعاب اللغوية المصممة على تعليم حروف الجر ملائمة لتطبيق في برنامج تقوية اللغة لقسم الإعداد اللغوي بجامعة الراية سوكابومي.
الكلمات المفتاحية: تصميم الألعاب اللغوية، حروف الجر، تقوية اللغة
Abstract

The researcher wants to design a language game to teach prepositions and verbs as a tool in this program. The method in this research is a quantitative and qualitative approach. The research methodology used by the researcher is descriptive-analytic research. Researcher design language games with the following steps: analyzing needs and problems, analyzing situations, determining questionnaire questions, planning general and specific goals, choosing language games, establishing teaching methods, managing the content of designed games, and evaluating language games. The results of the research and the validity of the designed language games are as follows: the results of a questionnaire from experts with a "good" grade. The results of the questionnaire from the head of the education department for female students reached 88%, and this shows that language games designed to teach (prepositions and verbs) are correct or accurate in a language consolidation program for the language preparation class of STIBA Arraayah Sukabumi.