bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEX-RELATED DIFFERENCES IN PHYSICAL ACTIVITY PATTERNS OF OLDER INDIVIDUALS LIVING IN THE SARDINIAN BLUE ZONE
Authors: Pau Massimiliano , Brandas Benedetta , Fastame Maria Chiara 
Published: January 2025

Abstract
Previous studies demonstrated that individuals born and resident in the Blue Zones (i.e, areas of exceptional longevity) exhibit reduced levels of depressive symptoms, better life satisfaction levels, and adopt more effective coping strategies to deal negative life events. However, few data is available regarding their physical activity (PA) profiles and, in particular, it is not known whether they are sex-related. Based on these considerations, in the present study we explored the effect of sex on a set of metrics which describe amount and intensity of physical activity (PA) in older people living in the Blue Zone of Sardinia (Italy). To this aim, 109 community-dwelling participants (Mage = 81.7 years old, SD = 8.1 years) were monitored for 7 days using a clinically validated wearable accelerometer which provided raw body accelerations as well as percentage of time spent in activities of different intensity namely sedentary behavior (SB), light PA (LPA) and moderate-to-vigorous PA (MVPA). The results showed that women exhibit a better PA profile with respect to men, characterized by significantly higher time spent in MVPA (+37%, p =.008) and reduced SB (-10%, p =.001). Also, those living in the Blue Zone exhibit higher PA levels with respect to peers resident in urban areas of Sardinia, thus suggesting that they adopt a more active lifestyle, which is thought to play a pivotal role in promoting functional and cognitive health in late adulthood. At the same time, futher studies are needed to clarify the nature of sex-related differences here observed.
MOBILITY DEVICE USE MODERATED BIDIRECTIONAL ASSOCIATION OF FEAR OF FALLING WITH HOMEBOUND STATUS
Authors: Li Qianyuan , Peng Wenting , Wang Shuomin , Yang Huili , Zhang Haihong , Liu Minhui 
Published: January 2025

Abstract
Previous studies showed fear of falling (FOF) is associated with homebound status, given that they have shared risk factors such as falls. However, the bidirectional relationship between fear of falling and homebound status and possible moderators remain unknown. Using the Year 2015-2019 waves of the National Health and Aging Trends Study, our sample included 3,983 community-dwelling older adults who had completed data on FOF and homebound status. We aimed to examine 1) whether FOF was associated with homebound status bidirectionally and 2) whether mobility device use moderated this bidirectional association. FOF was categorized as no FOF, FOF without fear-related activity restriction (FAR) and FAR. Based on the frequency, difficulty, and independence of outdoor mobility, homebound status was classified as non-homebound, semi-homebound, and homebound. The lagged generalized estimation equation models revealed that FOF without FAR (OR=1.34, 95% CI=1.19-1.52) and FAR (OR=1.62, 95% CI=1.38-1.91) increased the risks of semi-homebound/homebound status. Mobility device use moderated the longitudinal effects of FAR on homebound status with a statistical significance. Additionally, semi-homebound predicted the risks of FOF (OR=1.36, 95% CI=1.21-1.53), and its association was moderated by mobility device use. Overall, FOF is a risk factor for homebound status, and vice versa, and the risks may differ by the use of mobility devices. To prevent the progression of homebound status or FOF, future targeted strategies or community-based interventions should consider the fear of falling and homebound status simultaneously and identify the high risks of older adults who do not use mobility devices.
ASSOCIATION OF SEDENTARY BEHAVIORS WITH PERCEIVED PHYSICAL FATIGABILITY
Authors: Garcia Reagan , Johnson Eileen , Cawthon Peggy , Nicklas Barbara , Goodpaster Bret , Newman Anne , Glynn Nancy 
Published: January 2025

Abstract
Greater perceived fatigability is a phenotype of poor energy regulation and is associated with physical activity, cardiovascular fitness, and mitochondrial energetics. However, it is unclear whether time spent in low energy expenditure activities, i.e. sedentary behaviors, contribute to greater perceptual feelings of fatigue. We examined whether sedentary behaviors were associated with perceived physical fatigability using cross-sectional data in the Study of Muscle, Mobility and Aging (SOMMA). Participants wore an activPAL on their right thigh for 7 consecutive 24-hour periods (valid wear=≥1 day with ≥10 hours). Total min/day sedentary time, time per sedentary bout (min/day), and number of sit-to-stand transitions were calculated using mean of out-of-bed intervals. Perceived fatigability was measured using the Pittsburgh Fatigability Scale Physical subscale (PFS, score 0-50, higher=greater fatigability, more severe=≥15). Logistic regressions were adjusted for age, sex, body mass index, Short Physical Performance Battery (range 0-12), and cost-capacity ratio (VO2 from 0.67 m/s 5-min walk/VO2peak *100). Participants (n=685; 76.4±5.1 years, 58% Women, 85.1% Non-Hispanic White, 54.9% PFS Physical score ≥15) had mean 619.1±113.1 min/day sedentary time, mean 15.2±5.8 min/day per sedentary bout, and 45.9±13.4 sit-to-stand transitions/day. One standard deviation higher mean sedentary time was associated with 26% greater odds of reporting more severe perceived physical fatigability after full adjustment (OR=1.26, 95% CI: 1.05-1.52). Mean time per sedentary bout and sit-to-stand transitions were not associated with perceived physical fatigability. Sedentary behavior has modest associations with perceived fatigability. Our work supports that interventions to reduce fatigability severity could be modestly enhanced if overall sedentary time is reduced.
DISCOVERING BIOENERGETIC AND FITNESS PROFILES OF COMBINED PERCEIVED AND PERFORMANCE FATIGABILITY
Authors: Gay Emma , Rosano Caterina , Coen Paul , Garcia Reagan , Goodpaster Bret , Marcinek David , Newman Anne , Glynn Nancy 
Published: January 2025

Abstract
Demographic characteristics, skeletal muscle energetics, cardiorespiratory fitness (VO2peak), walking energetics, physical activity, and mobility are all independently associated with perceived and performance fatigability. Perceived and performance fatigability are distinct measurements that are complimentary to each other, and together could provide novel insight into potential targets for healthy aging interventions. We hypothesized that individuals with lower scores on both fatigability measurements (i.e., lower perceived/lower performance) will exhibit better cellular energetics and physical performance profiles compare to individuals with higher scores on both fatigability measurements (i.e., higher perceived/higher performance). Using a sample from SOMMA (n=799), we classified individuals using established severity cutpoints for the perceived-based Pittsburgh Fatigability Scale (PFS, range 0-50, lower&lt;15, higher≥15) and the performance-based Pittsburgh Performance Fatigability Index (PPFI, 0-100%, men: lower&lt;5.4%, higher≥5.4%, women: lower&lt;3.5%, higher≥3.5%). Skeletal muscle energetics were measured in vivo via magnetic resonance spectroscopy and ex vivo (biopsies) via high-resolution respirometry. Daily activity count was measured with wrist-worn accelerometry. We assessed VO2peak during a maximal treadmill cardiopulmonary test and walking energetics (cost-capacity ratio [VO2 from 0.67 m/s 5-min walk/VO2peak*100]). Compared to those with higher PFS/higher PPFI (n=73, 9.1%), individuals classified as lower PFS/lower PPFI (n=331, 41.4%) were 2 years younger, 33% more likely a man, 16% more activity, had 18.5% (0.19 m/s) faster 4m gait speed, 15-25% higher muscle energetics, 26% (5.2 mL/kg/min) higher VO2peak, and 11% lower cost-capacity ratio, all p&lt;0.05. Combining fatigability status revealed striking differences between lower PFS/lower PPFI vs higher PFS/higher PPFI, providing insight into targets (e.g., physical activity, bioenergetics, fitness) for intervention.
LEARNING YOGA ONLINE: PERSPECTIVES FROM OLDER WOMEN ENROLLED IN A CLINICAL TRIAL FOR URINARY INCONTINENCE
Authors: Nicosia Francesca , Chesney Margaret , Kaplan Celia , Arreguin Berty , Perez-Aguilar Giselle , Huang Alison 
Published: January 2025

Abstract
Yoga is increasingly used as a therapeutic modality for aging-related health conditions but the feasibility of engaging older adults in yoga is unclear. We conducted a multisite randomized trial of a therapeutic yoga intervention for ambulatory older women with urinary incontinence. The trial included twice weekly group instruction in Hatha yoga techniques delivered via interactive, synchronous, videoconference-based instruction. To assess barriers and facilitators to online instruction for this population, we used mixed methods. Structured questionnaires administered at 12-weeks measured convenience, audio-visual elements, and social connection, each on a 4-pt scale (1: Poor, 4: Excellent). Interviews examined the experience of learning yoga through synchronous video instruction at home. A hybrid deductive/inductive thematic approach was used to analyze interview transcripts. Among the 51 participants completing questionnaires (age range 49-81; 16% Asian, 16% Latina, 71% White), ratings of convenience were high (90.3% “good-excellent”); ratings of perceptions of personal connection with other participants were lower (60.8% “good-excellent”). Among the 24 participant interviews (age range 45-90; 21% Asian, 17% multiracial; 17% Latina, 54% White), common challenges were audio-visual and physical space limitations. For some, privacy of the home setting mitigated incontinence stigma. Increased body awareness and perceived effectiveness in reducing incontinence and stress facilitated sustained participation. Participants identified effective online teaching strategies including reinforcement of verbal instructions with visual demonstrations about body position during yoga postures and individualized attention. Despite challenges with online delivery, the convenience and privacy of the at-home setting provides opportunities to engage diverse, older women in movement-based therapeutic yoga interventions.
SLEEP AND ITS TREATMENT: EFFECTS ON PHYSICAL AND PSYCHOSOCIAL WELL-BEING
Authors: Kaufmann Christopher , Lee Soomi , Stone Katie 
Published: January 2025

Abstract
Sleep disturbances, dysregulated circadian rhythms, and related disorders can impact multiple aspects of life, including physical health, mobility, mental well-being, and other outcomes of relevance to aging populations. Treatments for specific disorders, such as Continuous Positive Airway Pressure (CPAP) for sleep apnea, are also important for promoting positive health outcomes. Therefore, it is crucial to conduct research that clarifies the relationships among sleep, its treatments, and overall health. In this symposium, we examine the complex interplay of sleep, sleep disorders, and circadian rhythms, with physical and psychosocial well-being in older populations and their caregivers. Our first presentation uses data from the National Health and Aging Trends Study to evaluate sleep health characteristics as risk factors for physical frailty, including gender differences in this relationship. Our second presentation evaluates the influence of disrupted rest/activity circadian rhythms (measured by wrist actigraphy) on metabolic syndrome among older adult participants in the Baltimore Longitudinal Study of Aging. Our third presentation evaluates sleep quality in family caregivers and whether psychological resilience moderates the association of caregiving status with sleep quality. Our fourth and final presentation, using data from the Health and Retirement Study, identifies the comorbid chronic health conditions that may predict CPAP discontinuation in older adults with sleep apnea to identify populations requiring greater monitoring to improve treatment effectiveness. Overall, this symposium emphasizes the importance of sleep and its role in promoting positive health and well-being in aging and diverse populations.
ASSOCIATIONS OF CIRCADIAN REST/ACTIVITY RHYTHMS WITH METABOLIC SYNDROME IN MIDDLE-AGED AND OLDER ADULTS
Authors: Yue Yiwei , Rabinowitz Jill , An Yang , Kaizi-Lutu Marc , Liu Chunyu , Simonsick Eleanor , Schrack Jennifer , Spira Adam 
Published: January 2025

Abstract
Circadian rhythm disturbances often co-occur with adverse cardiometabolic outcomes, including high blood pressure, obesity, and diabetes. However, the links between disrupted circadian rhythms and metabolic syndrome (MetS) are understudied in later life. This study examined associations between actigraphic circadian rest/activity rhythm (CRAR) metrics and MetS in 388 Baltimore Longitudinal Study of Aging participants who completed 6.6±1.0 nights of wrist actigraphy (Mean age=72.6±10.1, 20.6% Black adults, 54.1% women) and measures of MetS. Predictors were relative amplitude (RA), interdaily stability, intradaily variability, midpoint of total activity during the least active continuous 5 hours, and midpoint of total activity during the most active continuous 10 hours (M10 time). Participants were classified as having MetS if they had ≥3 of the following: triglycerides &gt;150 mg/dL; fasting blood glucose ≥100 mg/dL; high-density lipoproteins &lt;40 mg/dL for men and &lt;50 mg/dL for women; blood pressure ≥130/85 mmHg; waist circumference ≥102 cm for men and ≥88 cm for women. Overall, 39 participants had MetS at baseline and 24 developed MetS over 4.5±2.0 years of follow-up. Adjusting for demographics, physical activity, depressive symptoms, time, and interactions of time with covariates, higher RA was cross-sectionally associated with 29% lower odds of MetS (per SD, B=0.71, p=0.046). Longitudinally, a later M10 time was associated with a faster rate of increase in the odds of developing MetS (per SD, B=1.14, p=0.014). Findings link weaker and more phase-delayed CRARs to higher odds of MetS in middle-aged and older adults. Studies are needed to identify mechanisms linking disrupted CRARs to metabolic disorders.
CONSIDERATIONS FOR SUSTAINING DEMENTIA CARE INTERVENTIONS IN THE COMMUNITY
Authors: Shuman Sari 
Published: January 2025

Abstract
As community organizations implement dementia care interventions, they are tasked with the day-to-day intricacies of disseminating their chosen program. However, to ensure dementia services and supports remain in the community, they must assess how they can sustain the intervention into the future. The ability to continue dementia programs hinges on careful planning and consideration of several factors. Community organizations need to consider and assess the immediate and longer-term demand for the program in the geographic region being served, determine if they have or need to build organizational support, assess staffing needs and training abilities, and decide how they will continue to fund the dementia services and supports offered through the program if it is successful. In terms of funding, estimating the present and future costs of the dementia care intervention can help community organizations determine if the full program or only portions can be sustained using current or future funding mechanisms. Community organizations also need to secure the commitment from organizational decision makers to continue dementia care programs that have proven effective. Collecting and analyzing program data to demonstrate the program’s impact on participants can assist in garnering support from key organizational stakeholders. In this session, these considerations and others for sustaining dementia care interventions will be presented and discussed.
CHANGES IN SEDENTARY PATTERNS AND SELF-REPORTED HEALTH IN A RANDOMIZED CONTROLLED TRIAL OF SITTING REDUCTION
Authors: Rosenberg Dori , Acevedo Stefani Florez , Greenwood-Hickman Mikael Anne , Zhu Weiwei , Arterburn David , McClure Jennifer , Green Bev 
Published: January 2025

Abstract

Background
Interventions to reduce sedentary time in older adults have been limited to feasibility studies. Building off a series of pilot studies, we aimed to test the effects of the I-STAND sitting reduction intervention to reduce sedentary patterns and improve self-reported health outcomes.

Methods
283 participants were randomized to the I-STAND sitting reduction arm or an attention control condition. I-STAND included 10 brief health coach sessions, a tabletop standing desk, and fitness tracker to prompt sitting breaks. The attention control received 10 brief general healthy living focused sessions. The activPAL accelerometer worn for 7-days at baseline, 3, and 6 months measured sitting metrics. We measured pain interference, depression, loneliness and sleep disturbance by self-report. Linear regression models included baseline outcomes, covariates (e.g. demographics, health status), and whether randomization occurred pre- or post-pandemic.

Results
I-STAND (N = 140) and control (N = 143) participants mean age was 68.8 (SD 6.2) years, mean BMI was 34.9 (SD 4.7) kg/m2, 51.9% had hypertension. Participants were 65.7% women, 68.9% White, 14.5% Black, 5.7% Hispanic/Latinx, 4.2% Multiracial, and 3.2% Asian. Sitting time (-31.85 mins/day, p = 0.003), prolonged sitting bouts (-.57 bouts, p = 0.004), and mean sitting bout duration (-1.8 mins, p = 0.006) reduced while standing time increased (+27.7 minutes, p = 0.003) favoring the intervention. Loneliness reduced favoring I-STAND (-0.27, 95%CI: -0.52, -0.02, p=0.032).

Conclusion
I-STAND changed sitting patterns and improved loneliness. Uptake of sitting reduction interventions by older adults could improve physical and mental health.
THE NATIONAL COLLABORATORY TO ADDRESS ELDER MISTREATMENT MENTORSHIP PROGRAM: KEY LEARNINGS AND OPPORTUNITIES
Authors: Bangerter Lauren , Haggerty Kristin Lees , Mosqueda Laura 
Published: January 2025

Abstract
The National Collaboratory to Address Elder Mistreatment (NCAEM) recognizes that improving elder mistreatment identification, intervention, and prevention requires diverse mentorship. The NCAEM Mentorship program is a one-year program designed to mentor clinicians, service providers, researchers, policymakers, and advocates who are focusing on improving care for older adults experiencing or at risk of experiencing elder mistreatment. This symposium will begin by an overview of the NCAEM mentoring program history and goals and presentations from current and past mentees. Dr. Troutman-Jordan’s presentation will discuss their mentee project that included focus groups with home health nurses, as well as the process of then serving as a mentor and highlight opportunities for collaborative mentoring to address elder abuse. Dr. Simley will describe a mentee project focused on developing a survey for the Parkinson’s Foundation to help generate data to inform the development of a continuing education module on elder mistreatment among individuals living with Parkinson’s disease. Dr. Roberts will will focus on the role of the NCAEM in catalyzing interdisciplinary elder abuse research in long-term care settings, including nursing homes and assisted living. Dr. Steinman’s presentation will describe a mentee project focused on the conceptualization and development of a national study of racial/ethnic group differences in older adults’ involvement in Adult Protective Services. Dr. Marrs’s presentation will focus on the links between ageism and elder abuse and describe the development of an ageism public awareness project funded by the Administration for Community Living. Our discussant, Dr. Mosqueda, will provide summary remarks and moderate discussion.
UNPACKING THE RELATIONSHIP BETWEEN EDUCATION AND COGNITIVE DECLINE AND DEMENTIA
Authors: Herd Pamela , Walsemann Katrina 
Published: January 2025

Abstract
This session, which brings together a set of papers from participants in the Network on Education, Biosocial Pathways, and Dementia in Diverse Populations (EdDem), attends to the relationship between education and cognitive function and dementia in later life. The papers in this session explore two major themes. First, they examine the role of early and mid-life influences on these relationships. How do exposures to poor health in early life influence both educational attainment and subsequent risk for poor cognitive outcomes in later life? How does the content of early life schooling, including the rigor of the curriculum, influence both educational attainment and subsequent risk for poor cognitive outcomes in later life? The papers also consider the role of midlife factors, including occupation, health behaviors, and health conditions, in mediating the relationship between education and later life cognitive outcomes. Finally, these papers explore how the relationship between education and later life cognition varies within and across middle- and high-income countries. Overall, this set of papers helps unpack the persistent and robust relationship between education and cognitive function and dementia in later life. Session attendees will also have the opportunity to learn about the NIH-funded EdDem network, including funding and network related opportunities.
EDUCATION, OCCUPATIONAL ENVIRONMENT, AND COGNITIVE DECLINE IN LATE ADULTHOOD
Authors: Cao Katy (Qiuchang) , Carr Dawn , Taylor Miles 
Published: January 2025

Abstract
Education and occupational environment shape cognitive decline and Alzheimer’s Disease and Related dementias (ADRDs) in late adulthood. However, few studies have explored both factors simultaneously. This study aims to (1) Identify occupational environmental factors impacting cognitive decline and ADRD; (2) Analyze the separate or combined contributions of education and occupational environment to cognitive decline and ADRD; (3) Identify whether occupational environment mediates the association between education and cognitive decline/ADRD in late life. Structural Equation Modeling was conducted in Mplus using nationally representative data from the Health and Retirement Study (HRS) and Occupation Information Network (O*NET) linked dataset, incorporating new race/ethnicity adjusted ADRD measures. Confirmatory Factor Analyses suggested that hazardous exposure and cognitive complexity capture two separate but connected components of the occupational environment. Both the measurement (N=7301) and structural model (N=6345) demonstrated good model fit (TLI, CFI &gt;=.95, SRMR&lt;.08). Education had a positive direct effect on cognitive function (standardized direct effect = 0.08, p=0.002). Although the indirect effect of cognitive complexity was non-significant, hazardous occupational environment mediated education’s link to cognitive function (standardized indirect effect= 0.018, p=0.03). A one-unit increase in the hazardous occupational environment was associated with a 0.06 decline in cognitive function accounting for education, gender, race/ethnicity, depressive symptoms, baseline cognition, and age of the latest cognitive assessment. No statistically significant relationships between occupational exposure and ADRD were identified due to the limited waves of the new ADRD measures. Findings may inform interventions addressing occupational hazards to modify the association between early-life education and late-life cognitive outcomes.