bluuebunny/crossref_metadata_2025_split huggingface dataset:
Size Effects in 3D Printed Materials
Authors: CHEN YAO , Shergill Kietan , Bull Steve 
Published: December 2022

Abstract
The influence of layer thickness on the mechanical properties of polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS) 3D printed specimens made with fused filament fabrication (FFF) were investigated in this project. The analysis found that as the printing temperature increased, the mechanical properties of the PLA specimens decreased. The study also found that when increasing the layer thickness the mechanical properties of the specimens for both ABS and PLA decreased. The results showed that the value of breaking strain decreased as the layer thickness increased, which was true for both materials. The breaking strain of ABS was reduced by 11 % when the thickness was increased from 0.16 mm to 0.28 mm, whereas PLA's strain decreased by a more significant 27 %. When it came to ultimate tensile strength, the effect of layer thickness on PLA was more significant than on ABS. The study revealed that the ultimate tensile strength decreased as layer thickness increased, with the thinnest layer having a strength of 39.9 ± 2.3 MPa and the thickest having a value of 31.8 ± 1.2 MPa. Considering the mechanical properties as well as aspects such as printing time and simplicity of printing, an optimum print setting could be determined. The optimal printing temperature was found to be 200oC. The material chosen was PLA and the layer thickness selected is 0.16 mm. The study found that PLA was more significantly affected by the change in layer thickness compared to ABS.
Specific post-translational modifications of the soluble tau protein distinguish between Alzheimer’s disease, 4R-, and 3R-tauopathies
Authors: Zola Nathalie Kyalu Ngoie , Balty Clémence , Ruys Sébastien Pyr dit , Vanparys Axelle , Huyghe Nicolas , Herinckx Gaëtan , Johanns Manuel , Boyer Emilien , Kienlen-Campard Pascal , Rider Mark , Vertommen Didier , Hanseeuw Bernard 
Published: December 2022

Abstract
The tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The type of tau isoforms (4R/3R) observed in brain aggregates is used to classify tauopathies. However, distinguishing tauopathies in cerebrospinal fluid remains challenging. Here, we demonstrated that the difference in tau isoforms between tauopathies is only observed in aggregates, not in soluble brain extracts. We therefore used untargeted mass spectrometry to characterize all post-translational modifications of both the aggregated and the soluble tau protein obtained from human brain tissue of patients with Alzheimer’s disease, cortico-basal degeneration, Pick’s disease, and fronto-temporal lobe degeneration. We found specific soluble signatures predictive of each tauopathy and its peculiar type of aggregated tau isoforms. These findings provide potential targets for developing cerebrospinal fluid assays able to distinguish between tauopathies in vivo. The comparison between soluble and aggregated tau features indicates potential mechanisms of tau aggregation, providing novel therapeutic leads for these diseases.
Reliable and Secure Memristor-based Chaotic Communication Against Eavesdroppers and Untrusted Foundries
Authors: Vishwakarma Rahul , Monani Ravi , Hedayatipour Ava , Rezaei Amin 
Published: December 2022

Abstract
Chaos is a deterministic phenomenon that occurs in a non-linear dynamic system under the specific condition when the trajectories of the state vector become periodic and extremely sensitive to the initial conditions. While traditional resistor-based chaotic communications are primarily concerned with the safe transfer of information across networks, the transceivers themselves can be compromised due to outsourcing manufacturing. With the growth of wireless sensors in resource-constrained implantable and wearable devices, chaotic communication may be a good fit if the information transmitted is reliable and the transmitter devices are secure. We believe that memristor, as the fourth fundamental two-terminal circuit element, can close the gap between reliable communication and secure manufacturing since its resistance can be programmed and saved by the designer and not the foundry. Thus, in this paper, we propose a memristor-based Chua’s chaotic transceiver that is both reliable in the presence of eavesdroppers and secure against untrusted foundries. Specifically, we consider the pair of transmitter and receiver under the same memristor value to show the possibility of uninterrupted communication as well as cases wheredifferent values of memristors are used to find out the possible rangein which the message can still be meaningfully decoded. Experimen-tal results confirm that both reliable communication and secure designcan be achieved via our proposed memristor-based chaos transceivers.
An Android Malware Detection Approach Based on Summation of Multi-order Derivatives LSTM
Authors: Zhou Hanxun , Zhang Shuo , Yong Feng , Pan Hong , Guo Wei 
Published: December 2022

Abstract
With the popularity of the Android operating system on mobile devices, unscrupulous people prefer to attack Android devices, which results in the emergence of Android malware. This paper proposes an Android malware detection approach based on Summation of Multi-order Derivatives LSTM (SoMD-LSTM). In order to learn various runtime features of Android malware, the summation of multi-order derivatives is introduced to LSTM. As a result, SoMD-LSTM can describe the dynamic behavior of Android malware quantitatively by the summation of multi-order derivatives. Experiments show that the proposed Android malware detection approach has a better performance than LSTM and other methods.
Law of energy evolution under the stress path of deep surrounding rock
Authors: ZHENG Zhiming , Yang Yu , Pan Cheng 
Published: December 2022

Abstract
A triaxial test under different confining pressures of the sandstone of Fuxin Hengda Coal Mine was carried out using MTS812.02 test machine to study the elastic energy–strain relationship and damage failure mechanism of deep rock. Then, the energy calculation method was used to calculate the elastic energy of sandstone under different confining pressure conditions. The elastic energy curve of rock under different conditions was drawn. The relationship between strain and elastic energies of rock was established on the basis of the relationship between elastic energy and energy release rate during rock loading. The relationship between strain and elastic energies was simplified by introducing stress state parameters on the basis of the generalized Hooke’s law. The micro-element strength was assumed to satisfy the Weibull distribution, and a new energy nonlinear evolution model was established by introducing the concept of rock micro-element strength. The method of determining the distribution parameters was also proposed. Results showed that the model and the experimental data agreed well with the experimental results. The model was close to the deformation and failure law of rock and could reflect the relationship between elastic energy and strain of rock. This relationship was aggravated by the cumulative effect of microcracks and cracks in the rock and was concentrated in weak areas. The damage evolution model of rock increased with the increase in strain and inclined to 1. The microcracks also penetrated into macroscopic cracks, and the rocks were unstable and destroyed.
Monkey pox-epidemiology, clinical presentation and transmission: A systematic review
Authors: Sharma Ashima , Prasad Hari , Kaeley Nidhi , Bondalapati Aparna , Edara Lokesh , Kumar Y Ajay 
Published: December 2022

Abstract
Background: The new zoonotic viral infection monkeypox is a global health issue. Our study aimed at studying the epidemiology, clinical presentation, complications, case fatality rate, and transmission among the present cases of monkeypox infection.
Methods: Articles were searched in PubMed, Google Scholar, and Science Direct databases using the keywords 'Monkeypox' [MeSH] or 'Monkeypox virus (MeSH). Narrative reviews, conference abstracts, commentaries and articles in language other than English were excluded.
Results: Among 2352 confirmed cases studied from published literature which account for approximately 4% of infected cases worldwide. Around 81.71% of patients have a bisexual or Men having Sex with Men (MSM) preference. Approximately 30.18 % of confirmed cases were HIV positive. Male sex was also identified as a risk factor in our review.
Conclusion: As monkeypox human to human and human to animal transmission is rising. Researching preventive, clinicodemographic and therapeutic related to monkeypox is therefore crucial.
Effectiveness of the sarcopenia index in predicting respiratory failure among elderly patients with acute exacerbation of chronic obstructive pulmonary disease: a cross-sectional study
Authors: Zhao Xuanna , Su Ruoxin , Hu Rongwei , Chen Yujuan , Xu Xiaoyong , Yuan Yalian , Zhang Jinhong , Zhang Wenchao , Yang Yu , Chen Min , Li Dongming , Wu Bin , Huang Dan , Wu Dong 
Published: December 2022

Abstract
Background:Sarcopenia is a geriatric syndrome with progressive loss of skeletal muscle mass and function and has a negative impact on clinical outcomes associated with chronic obstructive pulmonary disease (COPD). Recently, the sarcopenia index (SI) was developed as a surrogate marker of sarcopenia based upon the serum creatinine to cystatin C ratio. We aimed to assess the value of SI for predicting clinically important outcomes among elderly patients with acute exacerbation of COPD (AECOPD).
Methods: This cross-sectional study included elderly patients with AECOPD in China from 2017 to 2021. Clinical data were collected from medical records, and serum creatinine and cystatin C were measured. Outcomes included respiratory failure, heart failure, severe pneumonia, invasive mechanical ventilation, and mortality. Binary logistic regression was used to analyze the association between SI and clinical outcomes.
Results: A total of 306 patients (260 men, 46 women, age range 60–88 years) were enrolled in this study. Among the total patients, the incidence of respiratory failure and severe pneumonia was negatively associated with SI values. After adjusting for potential confounding factors, binary logistic regression analyses showed that a higher SI was still independently associated with a lower risk of respiratory failure (odds ratio [OR]: 0.27, 95% confidence interval [CI]: 0.13–0.56, P < 0.05). In subgroup analysis, the incidence of respiratory failure was negatively associated with SI values in groups with both frequent exacerbation and non-frequent exacerbation. After adjustment for potential confounders, binary logistic regression analyses showed that a higher SI was also independently associated with a lower risk of respiratory failure in both groups (OR: 0.19, 95% CI: 0.06–0.64 and OR: 0.31, 95% CI: 0.11–0.85). However, there were no significant differences in the correlations between SI and the risk of heart failure, invasive mechanical ventilation, and mortality in all groups.
Conclusion: The SI based on serum creatinine and cystatin C can predict respiratory failure in patients with AECOPD and either frequent or infrequent exacerbations. This indicator provides a convenient tool for clinicians when managing patients with AECOPD in daily clinical practice.
Prostaglandin synthases and pro-inflammatory cytokine gene expression dynamics in bovine endometrial cells exposed to cow blood plasma small extracellular vesicles (sEV) reflect the fertility breeding value
Authors: Abeysinghe Pevindu , Turner Natalie , Mosaad Eman , Logan Jayden , Mitchell Murray D. 
Published: December 2022

Abstract
Aberrant inflammation in the endometrium impairs reproduction and leads to poor fertility. Small extracellular vesicles (sEV) are nanoparticles 30-200nm in-size and contain transferable bioactive molecules that reflect the parent cell. Holstein-Friesian dairy cows with divergent genetic merit, high- (n = 10) and low-fertile (n = 10), were identified based on fertility breeding value (BV), cow ovulation synchronization and postpartum anovulatory intervals (PPAI). In this study, we evaluated the effects of sEVs enriched from plasma of high-fertile (HF-EXO) and low-fertile (LF-EXO) dairy cows on inflammatory mediator expression by bovine endometrial epithelial (bEEL) and stromal (bCSC) cells. Exposure to HF-EXO in bCSC and bEEL cells yielded higher expression of PTGS1 and PTGS2 compared to the control. Pro-inflammatory cytokine IL1-α, IL-8/CXCL8 and IL-12α genes were downregulated in bCSC cells exposed to HF-EXO. In contrast, sEV exposure significantly lowered anti-inflammatory cytokine levels (CX3CL1 and IL-4) regardless high or low fertile states. Further, exposure to HF-EXO downregulated DES gene expression level in bCSC compared to the control. Our findings demonstrate that sEVs influence differential gene expression in endometrial cells, specifically genes relate to inflammation. Further, sEV from high-fertile animals acts in a unique direction to de-activate prostaglandin synthases in both bCSC and bEEL cells, and de-activate pro-inflammatory cytokines in the endometrial stroma. The results indicate identifying circulating sEV as a potential biomarker of fertility.
In vivo imaging of renal microvasculature in a murine ischemia-reperfusion injury model using optical coherence tomography angiography
Authors: Lee ByungKun , Kang Woojae , Oh Se-Hyun , Cho Seungwan , Shin Inho , Oh Eun-Joo , Kim You-Jin , Ahn Ji-Sun , Yook Ju-Min , Jung Soo-Jung , Lim Jeong-Hoon , Kim Yong-Lim , Cho Jang-Hee , Oh Wang-Yuhl 
Published: December 2022

Abstract
Optical coherence tomography angiography (OCTA) provides noninvasive three-dimensional structural and semiquantitative imaging of microvasculature in vivo. We developed an OCTA imaging protocol for a murine kidney ischemia-reperfusion injury (IRI) model to investigate the correlation between renal microvascular changes and ischemic damage. Mice were divided into mild and moderate IRI groups according to the duration of ischemia (10 and 35 min, respectively). Each animal was imaged at baseline; during ischemia; and at 1, 15, 30, 45, and 60 min after ischemia. Amplitude decorrelation OCTA images were constructed with 1.5-, 3.0-, and 5.8-ms interscan times, to calculate the semiquantitative flow index in the superficial (50-70 μm) and the deep (220-340 μm) capillaries of the renal cortex. The mild IRI group showed no significant flow index change in both the superfial and the deep layers. The moderate IRI group showed a significantly decreased flow index from 15 and 45 min in the superficial and deep layers, respectively. Seven weeks after IRI induction, the moderate IRI group showed lower kidney function and higher collagen deposition than the mild IRI group. OCTA imaging of the murine IRI model revealed changes in superficial blood flow after ischemic injury. A more pronounced decrease in superficial blood flow than in deep blood flow was associated with sustained dysfunction after IRI. Further investigation on post-IRI renal microvascular response using OCTA may improve our understanding of the relationship between the degree of ischemic insult and kidney function.
Establishment of efficient callus genetic transformation system for Hemerocallis fulva ‘Kanai’
Authors: Du Jinxue , Shi Jingbo , Pan Yiliang , Zhang Nan , Hou Fazhan , Liu Yingzhu , Liu Wei 
Published: December 2022

Abstract
Hemerocallis is regarded as a model plant for future breeding because of its high ornamental value and strong resistance. However, there are few reports on regeneration and genetic transformation of this plant. In this study, mature seeds of Hemerocallis fulva ‘Kanai’ were used as explants for regeneration and Agrobacterium infection. The results showed that the germination rate of explants with inner and outer seed coats peeled was 98% and the contamination rate was only 11%. The callus induction efficiency of MS medium supplemented with 3.5 mg∙L− 1 6-Benzylaminopurine (6-BA) and 0.1 mg∙L− 1 1-naphthylcetic acid (NAA) was 95.2%. Based on this, transformation was successfully achieved using the following protocol: callus were soaked in Agrobacterium tumefaciens EHA105 (OD600 = 0.6) containing pCambia1300-35S-FT and pCambia1300-35S-GUS plasmid for 15 min. After 3 days co-culture with 100 uM Acetosyringone (AS) in MS medium, it was transferred to MS medium containing 300 mg∙mL− 1 Timentin for 5 days. The Transgenic plants were obtained by hygromycin (9 mg∙mL− 1) screening. The presence of transgenic plants was confirmed by histochemical GUS detection and PCR (Polymerase chain reaction). Overall, the establishment of this efficient regeneration and genetic transformation will contribute to the functional gene research and genetic improvement of Hemerocallis fulva ‘Kanai’.
First report of environmental isolation of Cryptococcus spp. from Boyacá - Colombia
Authors: Briggith-Nathalia Serna-Espinosa , Maribel Forero-Castro , Eugenia Morales-Puentes María , Marcela Parra-Giraldo Claudia , Patricia Escandón , Adriana Sánchez-Quitan Zilpa 
Published: December 2022

Abstract
Background
The Cryptococcus genus comprises more than 80 species, of which C. neoformansand C. gattii are the leading cause of cryptococcosis. The distribution of C. gattii and C. neoformans complex has been extensively studied and widely reported globally. Other species such as C. albidus, C. laurentii, and C. flavescens have been reported as pathogenic yeast. Since there are no reports of environmental isolation in the Boyacá region (Colombia), this study aimed to isolate and characterize the species of Cryptococcus from pigeon feces, eucalyptus, and olive trees distributed in the municipalities of Tunja and Ricaute Alto.
Results
The environmental data was recovered, and the isolations obtained were identified by microscopy, biochemical test, MALDI-TOF, RFLP of the URA5 gene, and sequencing of the ITS and LSU gene.
For the 93 pigeon dropping samples collected in Tunja, 23 corresponded to C. neoformans, 3 to C. saitoi, 2 C. albidus and 1 to C. laurentii. Of the 1188 samples collected from olive trees, 17 (1.43%) positive samples were identified as C. gattii (4), C. neoformans var. grubii (2), C. laurentii (3), C. albidus (2), C. saitoi (5) and C. flavescens (1). Likewise, specimens of C. neoformans var. grubii presented molecular type VNI and molecular type VNII; for C. gattii the molecular types found were VGIII and VGIV.
Conclusions
Therefore, it can be concluded that the species of Cryptococcus genus, are present in the environment of Boyacá, and show a predilection for climate conditions that are typical of this region.
Depleting gut microbiota resistance in Alzheimer's disease enhances the therapeutic effect of mesenchymal stem cell-derived exosomes
Authors: Hou Xuejia , Jiang Hongyu , Liu Te , Yan Jun , Zhang Fuqiang , Zhang Xiaowen , Zhao Jingtong , Mu Xupeng , Jiang Jinlan 
Published: December 2022

Abstract
Mesenchymal stem cell-derived exosomes (MSCs-exo) can be used for treating Alzheimer’s disease (AD) by promoting amyloid-β (Aβ) degradation, modulating immune responses, protecting neurology, promoting axonal growth, and improving cognitive impairment. Increasing evidence suggests that the alteration of gut microbiota is closely related to the occurrence and development of Alzheimer's disease. In this study, we hypothesized that dysbiosis of gut microbiota might limit the effectiveness of MSCs-exo, whereas regulating the gut microbiota would improve the therapy of MSCs-exo. Methods: In this original research study, we used MSCs-exo to treat 5×FAD mice and fed them antibiotic cocktails for 1 week to detect cognitive ability and neuropathy. The mice’s feces were collected to investigate alterations in the microbiota and metabolites. Results: The results revealed that the AD gut microbiota eliminated the therapeutic effect of MSCs-exo, whereas antibiotic modulation of disordered gut microbiota and associated metabolites enhanced the therapeutic effect of MSCs-exo. Conclusions: These results encourage the research of novel therapeutics to enhance MSCs-exo treatment for AD, which could benefit a broader range of patients with AD.
Oil absorption stability of modified cellulose porous materials with super compressive strength in the complex environment
Authors: Lang Daning , Zhang Chengbo , Qian Qianqian , Guo Chengxin , Wang Lingling , Yang Chao , Wu Ronglan , Wang Wei , Wang Jide , Fu Jihong 
Published: December 2022

Abstract
The frequent oil spill has dramatically harmed the ecosystem and human health. Therefore, developing a green, recyclable, complex environment resistant and efficient oil-water separation aerogel is necessary to absorb marine oil or industrial oil. The modified cellulose/N,N'-methylenebisacrylamide (MBA)/tannin (PCMT) composite porous materials were prepared by the sol-gel method and modification of tertbutyl acrylate (TBA). PCMT had a three-dimensional interpenetrating porous structure, good oil-water separation performance and excellent compressive strength (both can bear 7000 times of its own weight; PCMT0.2 could endure 290.3 kPa pressure at 80% strain). The unique pore structure of PCMT resulted in different oil adsorption capacities (PCMT0, PCMT0.05, PCMT0.1, and PCMT0.2 had higher adsorption capacities for petroleum ether and dichloromethane, n-hexane and dichloromethane, toluene, and toluene and dichloromethane, respectively). Importantly, PCMT had excellent adaptability to complex environments. The porous materials could maintain good hydrophobicity and oil absorption ability under the conditions of vigorous stirring, wide pH range (1 ~ 14), wide temperature range (4 ~ 160oC), ultraviolet irradiation (8 h), and tape peeling (10 times). In addition, porous materials could be used to recover oil by simple mechanical extrusion, which had certain economic significance and application potential in oil spill treatment.
Development of artificial neural network based mathematical models for predicting small scale quarry powder factor for efficient fragmentation coupled with uniformity index model
Authors: Taiwo B. O. , Yewuhalashet F. , Ogunyemi O. B. 
Published: December 2022

Abstract
Blasting powder factor is an important consideration when planning a drilling and blasting operation because it affects both the total production cost and the efficiency of downstream operations. Ten production blasts and 38 blast record datasets from a small scale dolomite quarry in Akoko Edo, Nigeria were studied to determine the effect of powder factor on blast fragmentation size distribution and uniformity index. This research evaluated the relationship between powder factor and fragmentation size distribution, as well as apply artificial neural network to model small diameter drill hole blast powder factor based on predominant controllable blast design factors. According to the research, the small scale blasting powder factor ranges between 0.6 and 1.0 kg/m3. According to the WipFrag analysis, increasing the powder factor causes an increase in the fragmentation mean size and an upward shift in the particle size distribution curve. The mine blasting operation uniformity index was also found to be between 1.3 and 1.68. The powder factor range of 0.7-0.9kg/m3 was determined by the uniformity index. The performance of the proposed ANN model was evaluated using the correlation coefficient and found to have a high prediction accuracy (R2 = 0.997). As a result, the proposed ANN models can be used to improve the blast powder factor for real-world applications.