bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Buyang Huanwu granules and Naoxintong capsules in the treatment of stable angina pectoris: rationale and design of a randomized, blinded, multicentre clinical trial
Authors: Wang Yu , Xu Yuhan , Zhang Ling , Huang Shuwei , Dou Liping , Yang Jiehong , Fu Wei , Zhou Peng , Wan Haitong 
Published: January 2022

Abstract
Background
Stable angina pectoris (SAP) currently seriously threatens the health of humans, and mortality is continuously rising. Current treatment strategies mainly include pharmaceutical therapy and revascularization. In China, Buyang Huanwu granules (BYHW) and Naoxintong capsules (NXT) have been used in the treatment of SAP, but it is not clear which agent is better in terms of relieving symptoms and improving quality of life. Therefore, we designed a clinical trial to compare the efficacy and safety of NXT and BYHW in the treatment of SAP.

Methods
This is a randomized, blinded, parallel controlled, multicentre clinical trial protocol. On the basis of standardized Western medicine treatment, a total of 128 SAP patients will be randomly divided into intervention group 1 (NXT group), intervention group 2 (BYHW group), and a control group (placebo group) at a 2:1:1 ratio. A 2-week run-in period is required prior to randomization, and a 1-week baseline period and 4-week treatment period are included in this study. The primary outcome is the efficacy rate of stable angina symptom score improvement; the secondary outcomes include the effect on electrocardiograms, Seattle Angina Questionnaire scores, and nitroglycerine consumption.

Discussion
This study will evaluate the efficacy and safety of NXT and BYHW in the treatment of SAP. The results will provide critical evidence for using Chinese herbal medicines to treat SAP.

Trial registration
Chinese Clinical Trials Registry ChiCTR1800015191. Registered on 13 March 2018. http://www.chictr.org.cn/showproj.aspx?proj=25818. All the registration items can be found within the protocol.
Clinical characteristics and allergen detection of perioperative anaphylaxis: a 12-year retrospective analysis from an anesthesia clinic in China
Authors: Liu Xiaowen , Gong Ruisong , Xin Xin , Zhao Jing 
Published: January 2022

Abstract

Background
Anaphylaxis during anesthesia is a rare but often a potentially life-threatening event for patients. Identifying culprit agents responsible for anaphylaxis is of great important for avoiding potential re-exposure to allergens, but it poses great challenge for anesthetists. This retrospective study aimed to analyze the culprits of patients with a history of perioperative anaphylaxis referred to an anesthesia allergy clinic in China, and to evaluate the role of allergy diagnostic tests in clinical practice.

Methods
A total of 145 patients (102 female/43 male) who attended the Anesthesia Allergy Clinic for allergen detection between 1 January 2009 and 31 December 2020 were reviewed retrospectively. Clinical characteristics, results of allergy diagnostic tests including skin, and/or basophil activation tests, and the incidence of repeat anaphylaxis after use of recommended alternative anesthetics were obtained.

Results
Of these 145 patients, 109 patients (75.2%, 74 females/35 males) were determined to experience perioperative anaphylaxis. The most common presenting clinical feature was cardiovascular manifestations (n = 63, 57.8%). According to diagnostic work up, the most common causative agents for perioperative anaphylaxis were neuromuscular blocking agents (n = 35, 32.1%). After diagnostic work up, 52 patients underwent repeat anesthesia. None of these patients experienced recurrent anaphylaxis.

Conclusions
This study suggests that neuromuscular blocking agents are the main cause of perioperative anaphylaxis. For patients with perioperative anaphylaxis, allergy diagnostic tests are essential to identify causative agents, and to find suitable alternative drugs for the future planning of subsequent anesthetics.
The soybean cultivar SCEL-1 shows potent anti-photoaging effects in a UV-induced three-dimensional human skin and hairless mouse model
Authors: Lee Jin Woo , Peng Lei , Jegal Hyun , Park No-June , Bong Sim-Kyu , Lee Joon Won , Pyo Jeong Joo , Choi Yongsoo , Kim Su-Nam 
Published: January 2022

AbstractSoybean (Glycine max) is one of the major sources of nutrition and is used as a raw material for food and as a source of feed for livestock. The efficacy of soybeans on skin health includes their ability to reduce wrinkles and pigmentation and increase skin elasticity and moisture content. Black soybean has been consumed worldwide for a long time, especially in Korea, and is used as a medicinal food against several disorders related to the skin. To evaluate whether its effect on the skin is different based on the cultivar of soybeans, three black soybean cultivars collected in Korea, Soybean Core collection Elite Line-1 (SCEL-1), Chung Ja-3 (CJ-3) and Won Heuk (WH), were selected to compare their effect on improving photoaging induced by ultraviolet rays (UVs). We found that SCEL-1 exhibited the best efficacy among the three cultivars tested, and treatment with this soybean extract significantly reduced the expression of matrix metalloproteinase-1 (MMP-1), preventing the degradation of collagen in a 3D human skin model. In addition, SCEL-1 application improved wrinkle- and photoaging-related symptoms, such as epidermal thickening, collagen deficiency and immune cell infiltration, in an animal model established by UV irradiation. Procyanidin B2 and epicatechin isolated from the SCEL-1 cultivar inhibited MMP-1 biosynthesis in UVB-irradiated human dermal fibroblasts, and these two major components are likely related to more significantly attenuated skin photoaging. Therefore, our results indicated that SCEL-1 exhibits good anti-wrinkle effects compared to the other two black soybean cultivars, suggesting that it represents an excellent agent for anti-photoaging.
Synthesis and characterization of novel ssDNA X-aptamers targeting Growth Hormone Releasing Hormone (GHRH)
Authors: Ayhan-Sahin Burcu , Apaydın Zeynep-Elif , Obakan-Yerlikaya Pınar , Arisan Elif-Damla , Coker-Gurkan Ajda 
Published: January 2022

BackgroundGrowth Hormone Releasing Hormone (GHRH), 44 amino acids containing hypothalamic hormone, retains the biological activity by its first 29 amino acids. GHRH (NH2 1–29) peptide antagonists inhibit the growth of prostate, breast, ovarian, renal, gastric, pancreatic cancerin vitroandin vivo. Aptamers, single-strand RNA, or DNA oligonucleotides are capable of binding to target molecules with high affinity. Our aim in this study is to synthesize and select X-aptamers against both GHRH NH2 (1–29) and GHRH NH2 (1–44) and demonstrate synthesized aptamers’ target binding activity as well as serum stability.Methods and resultsAptamers against GHRH NH2 (1–44) and NH2 (1–29) peptides were synthesized, and binding affinity (Kd) of 24 putative X-aptamers was determined by the dot-blot method, co-immunofluorescence staining and, SPR analysis. The serum stability of TKY.T1.08, TKY1.T1.13, TKY.T2.08, TKY.T2.09 X-aptamers was 90–120 h, respectively. The dose-dependent binding of TKY1.T1.13, TKY.T2.08, TKY.T2.09 X-aptamers on GHRHR in MIA PaCa-2 was approved by co-IF assay results. Moreover, SPR analysis indicated the Kd(4.75, 1.21, and 4.0 nM) levels of TKY2.T1.13, TKY.T2.08, TKY.T2.09 putative X-aptamers, respectively.ConclusionOur results illustrate the synthesis of 24 putative X-aptamers against both GHRH NH2 (1–44) and NH2 (1–29) peptides and TKY1.T1.13, TKY.T2.08, TKY.T2.09 X-aptamers have high serum stability, high target binding potential with low Kdlevels.
Effects of antibiotic treatment on microbiota, viral transmission and viral pathogenesis of MoMuLV ts1 infected BALB/c mice
Authors: Okonta Henry , Cheng Xi , Chakravarti Ritu , Duggan Joan 
Published: January 2022

The effects of normal and altered intestinal microbiota on murine retroviral transmission via the gastrointestinal tract (GIT) are diverse. The role of orally administered antibiotic treatment (ABX) on viral transmission, GIT microbial dysbiosis and subsequent pathogenesis of Moloney Murine Leukemia virus–temperature sensitive 1 (ts1) on BALB/c mice were studied. BALB/c mice were divided into four groups:

ABXts1—Treatment/Infection;
ABX—Treatment/No infection;
ts1—No treatment/Infection;
Ctrl (control)—No treatment/No infection.

ABXts1 and ABX groups showed a significant phylogenetic shift (ANOSIM p-value = 0.001) in alpha and beta diversity comparisons for microbial community composition compared to Ctrl group. Mice in the ABXts1 and ABX groups showed megacolon compared to ts1 and Ctrl groups; ABXts1 and ts1 groups showed hepatosplenomegaly, thymus enlargement, and mesenteric lymphadenopathy compared to ABX and Ctrl groups. Ctrl group had no abnormal manifestations. ABX treatment and ts1 infection uniquely affect microbial community when compared to control: ABXts1 and ABX groups significantly reduce microbiome diversity by over 80% and ts1 group by over 30%. ABXts1 and ts1 groups’ viral load and clinical manifestations of infection were comparable; antibiotic treatment did not notably affect ts1 infection. Transmission and pathophysiology of ts1 infection were not significantly altered by the microbial composition of the GI tract, but ts1 viral infection did result in microbial dysbiosis independent of antibiotic treatment.
“Post-GDM support would be really good for mothers”: A qualitative interview study exploring how to support a healthy diet and physical activity after gestational diabetes
Authors: Dennison Rebecca A. , Griffin Simon J. , Usher-Smith Juliet A. , Fox Rachel A. , Aiken Catherine E. , Meek Claire L. 
Published: January 2022

BackgroundWomen with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes mellitus (T2DM). They are therefore recommended to follow a healthy diet and be physically active in order to reduce that risk. However, achieving and maintaining these behaviours in the postpartum period is challenging. This study sought to explore women’s views on suggested practical approaches to achieve and maintain a healthy diet and physical activity to reduce T2DM risk.MethodsSemi-structured interviews with 20 participants in Cambridgeshire, UK were conducted at three to 48 months after GDM. The participants’ current diet and physical activity, intentions for any changes, and views on potential interventions to help manage T2DM risk through these behaviours were discussed. Framework analysis was used to analyse the transcripts. The interview schedule, suggested interventions, and thematic framework were based on a recent systematic review.ResultsMost of the participants wanted to eat more healthily and be more active. A third of the participants considered that postpartum support for these behaviours would be transformative, a third thought it would be beneficial, and a third did not want additional support. The majority agreed that more information about the impact of diet and physical activity on diabetes risk, support to exercise with others, and advice about eating healthily, exercising with a busy schedule, monitoring progress and sustaining changes would facilitate a healthy diet and physical activity. Four other suggested interventions received mixed responses. It would be acceptable for this support to be delivered throughout pregnancy and postpartum through a range of formats. Clinicians were seen to have important roles in giving or signposting to support.ConclusionsMany women would appreciate more support to reduce their T2DM risk after GDM and believe that a variety of interventions to integrate changes into their daily lives would help them to sustain healthier lifestyles.
MIT-E3: modelo constitutivo para argilas. Formulação, potencialidades e limitações
Authors: Oliveira Paulo 
Published: January 2022

Neste artigo apresenta-se a formulação do modelo constitutivo MIT-E3, sendo um dos modelos mais evoluídos para a simulação do comportamento de argilas normalmente consolidadas e moderadamente sobreconsolidadas. São apresentadas as principais características do modelo e a sua formulação matemática, a qual é subdividida em termos de comportamento normalmente consolidado e sobreconsolidado.
As capacidades e limitações do modelo são ilustradas através da simulação de ensaios laboratoriais: ensaio de descarga em Ko, ensaio unidimensional de deformação controlada (CRS), ensaios triaxiais não drenados e ensaios de corte simples não drenados.
Finalmente, o modelo é aplicado na simulação de um aterro experimental realizado sobre um depósito constituído por argila "Boston Blue Clay", estabelecendo-se o confronto com o comportamento observado "in situ" e com uma análise numérica efectuada com o modelo Cam Clay Modificado (CCM), em termos da evolução temporal dos assentamentos, das deformações laterais e dos acréscimos das pressões de água nos poros. Também se comparam os resultados provenientes de ambas as análises numéricas (CCM e MIT-E3) em termos da extensão das zonas em cedência, das isolinhas dos acréscimos das tensões efectivas verticais e horizontais, das isolinhas dos acréscimos das pressões intersticiais e das direcções das tensões principais.
Persepsi Mahasiswa Tentang Implementasi Blended Learning pada Mata Kuliah Strategi Pembelajaran Akuntansi
Authors: Septiana Yolandaru 
Published: January 2022

Penelitian ini bertujuan untuk mendeskripsikan persepsi mahasiswa tentang implementasi blended learning dalam mata pelajaran Strategi Pembelajaran Akuntansi. Penelitian ini adalah penelitian survei. Metode penelitian ini adalah metode kuantitatif. Sampel penelitian ini adalah mahasiswa Prodi Pendidikan Akuntansi, Fakultas Ekonomi, Universitas Negeri Yogyakarta yang telah mengambil mata pelajaran Strategi Pembelajaran Akuntansi, sebanyak 36 mahasiswa. Teknik pengumpulan data menggunakan kuesioner. Teknik analisis data menggunakan teknik deskriptif kuantitatif. Kesimpulan dari penelitian ini adalah persepsi mahasiswa tentang blended learning. Blended learning merupakan sistem baru, mudah, dan efektif. Melalui Besmart, sebagian besar siswa merasa bertanggung jawab atas kuliah, termotivasi, membantu membuat perencanaan, dan melakukan persiapan sebelum di kelas untuk kuliah. Mahasiswa dapat belajar di lingkungan yang nyaman, sesuai dengan kecepatan mereka sendiri dan dapat belajar berulang kali. Terdapat 38,89% mahasiswa berpendapat bahwa Besmart lebih baik daripada metode lain. Sebagain kecil mahasiswa berpendapat bahwa mereka merasa bosan, merasa sulit untuk belajar melalui Besmart, dan forum diskusi yang membosankan.
Kata kunci: Implementasi, Blended Learning; Strategi pembelajaran Akuntansi
Natural Scientific Thinking in Foreign Students of Pre-University Courses in the Context of Integration into the Russian Educational Environment
Authors: Fisenko O. , Nikitina V. , Satina T. 
Published: January 2022

This article is the result of a two-year-long experiment conducted by the authors. The purpose of the research was to study the natural scientific thinking of foreign students of preparatory departments in the context of integrative processes. The quantitative and qualitative analysis of the regulatory framework governing the educational process at the stage of pre-university training, including syllabi and steering documents of faculties of pre-university training, formed the methodological basis of the research. The modified criteria-focused TEM-11 test was used as a diagnostic tool. The method of expert evaluations ensured the reliability and validity of the research. The study provided evidence of the feasibility of including an integration course in “biophysics” along with biology, physics, and chemistry in the curricula of preparatory departments that prepare foreign students for admission to medical, agricultural, veterinary, and biological faculties. It does not appear reasonable to include an online course in the training system for foreign students who are residents since they already developed the differential-synthetic and synthetic stages of natural scientific thinking while they were learning the trade. It is concluded that the Biophysics integrative online course studied by foreign students of faculties of pre-university training, develops a special type of natural scientific thinking, which will be the basis for framing professional thinking in the future. A total of 374 people took part in the experiment (188 people were included in the experimental group and 186 people became part of the control group). The comparative analysis of the stages of development of natural scientific thinking in the control and experimental groups showed significant progress in the experimental group. After the experiment, the number of respondents at the common empirical stage of development of natural scientific thinking was 11.2 % of the entire sample; the number of respondents at the scientific empirical stage was 32.8 %, at the synthetic differential stage – 44.7 % and at the synthetic stage – 27.6 %.
Perfil mineral de los alimentos importados para mascotas en Costa Rica
Authors: Cedeño-López André , WingChing-Jones Rodolfo 
Published: January 2022

Introducción. El contenido mineral de los alimentos para mascotas no siempre está presente en la etiqueta. Es importante conocer esta información para valorar el aporte nutricional del alimento. Objetivo. Determinar el contenido de Ca, P, K, Na, Mg, S, Cu, I, Fe, Mn y Zn en 34 alimentos importados para perros, gatos, conejos, hámsters, peces ornamentales y tortugas, y comparar los resultados con las recomendaciones encontradas en la literatura. Materiales y métodos. Durante los meses de agosto y diciembre del año 2018, se obtuvieron diez muestras de alimentos para perros y gatos, cinco para peces ornamentales, cuatro para tortugas, tres para hámster y dos para conejos. Estas se adquirieron de manera directa en diferentes puntos de venta en la Gran Área Metropolitana, San José, Costa Rica. Las muestras se analizaron en el Centro de Investigación en Nutrición Animal de la Universidad de Costa Rica. Se cuantificaron los minerales Ca, P, K, Mg, S, Cu, I, Fe, Mn, y Zn con base en la metodología recomendada por la Association of Official Analytical Chemists. Se calculó el contenido promedio por grupo de alimento según la especie animal, la desviación estándar, valores máximo y mínimo; se comparó con las recomendaciones nutricionales para minerales encontradas en la literatura. Resultados. Los alimentos estudiados cumplieron, en promedio, con los requerimientos minerales de los animales de compañía. Se observaron desbalances en el contenido de Ca, P y Mg para el caso de alimentos para tortugas, altos contenidos de yodo en alimentos para perros y relaciones desbalanceadas entre minerales. Conclusiones. Se generó una base de datos con valores promedios y su dispersión en once minerales en 34 muestras de alimentos comerciales de siete animales de compañía en Costa Rica. Se observó la poca información sobre límites superiores recomendados y requerimientos en especies como hámster, peces ornamentales o tortugas.
El peix que es mossega la cua. Estudio de caso de la responsabilidad social empresarial de una compañía multinacional
Authors: González Ospina Elizabeth 
Published: January 2022

Este artículo analiza los discursos que se desprenden de la gestión de la responsabilidad social empresarial de una compañía multinacional del sector de la alimentación1. En los últimos años la compañía Zucker ha estado asociada a varios fenómenos globales críticos como la promoción de productos alimentarios nocivos para la salud, la explotación laboral, y el uso de insumos relacionados con problemas medioambientales. Lo anterior ha significado la pérdida de credibilidad ante los consumidores, que reclaman mayor transparencia y compromiso en aspectos como cadenas de suministros. La compañía, al reevaluar los impactos de su actividad empresarial, ha puesto en marcha una serie de mecanismos que apuntan a «fomentar la sostenibilidad de la cadena de suministro agrícola», pero también ha activado otros como campañas de relaciones públicas, estrategias publicitarias y de divulgación «científica». En esta vía, ha capturado conceptos como desarrollo sostenible, comercio justo, sostenibilidad y economía circular, incorporándolos a sus discursos y prácticas de responsabilidad social empresarial, en la búsqueda de legitimidad social y de mejora de su reputación.
Effect of Consumer Trust on Consumer Buying Behavior towards Automobiles
Authors: U. Premkumar, Dr. S. Shanmugasundaram  
Published: January 2022

` The intention of the present research study is to explore and analyze the influence of the consumer trust on the buying behavior of the consumers towards the automobile’s purchase. The data needed for the study was both primary and secondary. Primary data was collected through questionnaires and also through face to face questioning. The secondary data was collected through the review of the previous study done in this regard. The secondary data was also collected from the newspapers, published reports, journals and websites. The study has been done among the consumers who purchase automobiles in Chennai. The respondents for the study are selected through simple random sampling and the sample size of the study is 100. The data needed for the study has been collected through a questionnaire and the analytical part of the study is done with the help of regression. The findings of the analysis show that __________.
Structural and Procedural Factors Affecting Correct Application of the Rules of Jurisdiction in Civil Cases
Authors: Bekyasheva D. I. 
Published: January 2022

The maxim of the positivist approach, according to which the courts must strictly follow the letter of the law, today keeps turning into the abolition of judicial acts «in view of unclear, ambiguous legislative regulation of competence delimitation lacking specificity and due clarity,» which does not exclude referring the case for a new hearing (with proper consideration of the merits of the case in previous instances). Courts do not apply uniformly amendments to the procedural legislation (Federal Law of 28.11.2018 No. 451), as well as new clarifications that appeared in the context of the amendments (Resolution of the Plenum of the RF Supreme Court of 30.06.2020 No. 12; Resolution of the Plenum of the RF Supreme Court of 22.06.2021 No. 16) that have finally overcome contradictions between traditional understanding by the Constitutional Court of the Russian Federation of the right to a competent court and the ideas of the ECHR concerning objections to jurisdiction only in the court of first instance. In situations when a court decision is overturned and referred for a new consideration to the court of first instance, the classical understanding of the constitutional right to defence by a competent court looks like an image, a weak effort to lend legitimacy to the arguments provided by the appellate court. Taking into account that the rules of competence and jurisdiction are far from always being determined according to the merits and features of the case, and amendments made to the procedural legislation concerning distribution of cases between courts still do not implement the proposal of the Constitutional Court of the Russian Federation to enshrine in the law a criterion that allows determining a competent court, and that they are implemented arbitrarily, it is proposed to clearly formulate the rule restricting both participants in a disputed legal relationship to make procedural objections based on the lack of jurisdiction of the court of appeal, if such a right could have been exercised in a court of first instance, and the rule to overrule the decision only in cases where a person was really restricted in access to justice and the exercise of the right to judicial protection due to violation of jurisdictional rules.