bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the Oncology Care Model on Use of Supportive Care Medications During Cancer Treatment
Authors: Brooks Gabriel A. , Landrum Mary Beth , Kapadia Nirav S. , Liu Pang-Hsiang , Wolf Robert , Riedel Lauren E. , Hsu Van Doren , Jhatakia Parekh Shalini , Simon Carol , Hassol Andrea , Keating Nancy L. 
Published: February 2022

PURPOSE The Oncology Care Model (OCM) is an episode-based alternative payment model for cancer care that seeks to reduce Medicare spending while maintaining care quality. We evaluated the impact of OCM on appropriate use of supportive care medications during cancer treatment. METHODS We evaluated chemotherapy episodes assigned to OCM (n = 201) and comparison practices (n = 534) using Medicare claims (2013-2019). We assessed denosumab use for beneficiaries with bone metastases from breast, lung, or prostate cancer; prophylactic WBC growth factor use for beneficiaries receiving chemotherapy for breast, lung, or colorectal cancer; and prophylactic use of neurokinin-1 (NK1) antagonists and long-acting serotonin antagonists for beneficiaries receiving chemotherapy for any cancer type. Analyses used a difference-in-difference approach. RESULTS After its launch in 2016, OCM led to a relative reduction in the use of denosumab for beneficiaries with bone metastases receiving bone-modifying medications (eg, 5.0 percentage point relative reduction in breast cancer episodes [90% CI, –7.1 to –2.8]). There was no OCM impact on use of prophylactic WBC growth factors during chemotherapy with high or low risk for febrile neutropenia. Among beneficiaries receiving chemotherapy with intermediate febrile neutropenia risk, OCM led to a 7.6 percentage point reduction in the use of prophylactic WBC growth factors during breast cancer episodes (90% CI, –12.6 to –2.7); there was no OCM impact in lung or colorectal cancer episodes. Among beneficiaries receiving chemotherapy with high or moderate emetic risk, OCM led to reductions in the prophylactic use of NK1 antagonists and long-acting serotonin antagonists (eg, 6.0 percentage point reduction in the use of NK1 antagonists during high emetic risk chemotherapy [90% CI, –9.0 to –3.1]). CONCLUSION OCM led to the reduced use of some high-cost supportive care medications, suggesting more value-conscious care.
The Prognosis of Skip Metastasis in Papillary Thyroid Microcarcinoma Is Better Than That of Continuous Metastasis
Authors: Weng Huai-Yu , Yan Ting , Qiu Wang-Wang , Fan You-Ben , Yang Zhi-Li 
Published: February 2022

Abstract

Context
A few papillary thyroid microcarcinomas (PTMCs) may have skip metastasis (SLNM), but the risk factors remain controversial and the prognosis is unclear.

Objectives
To investigate the incidence, lymph node metastasis (LNM) patterns, risk factors, and prognosis of SLNM in PTMCs.

Methods
We reviewed the medical records of PTMC patients who underwent thyroid surgery in our institution. Analyses of risk factors were performed for SLNM. Recurrence-free survival (RFS) of SLNM, central lymph node metastasis (CLNM), and continuous metastasis (CLNM and lateral lymph node metastasis [CLNM + LLNM]) were compared after propensity score matching (PSM).

Results
SLNM was detected in 1.7% (50/3923) and frequently involved level III (66.7%). Compared with CLNM + LLNM, SLNM had more LNM at a single level (P &lt; 0.01) and less LNM at 2 levels (P &lt; 0.05). A tumor size of 0.5 to 1 cm (odds ratio [OR], 2.26; 95% CI, 1.27-4.00) and location in the upper pole (OR, 3.30; 95% CI, 2.02-5.40) were independent risk factors for SLNM. A total of 910 (23.2%) PTMCs with LNM were included in the prognostic analysis. At a median follow-up of 60 months, the RFS of SLNM did not differ from that of CLNM (P = 0.10) but was significantly higher than that of CLNM + LLNM (P &lt; 0.01) after using PSM.

Conclusions
When the tumor size is 0.5 to 1 cm or its location is in the upper pole, we must remain vigilant to SLNM in PTMC. Because its prognosis is comparable to that of only CLNM and better than that of CLNM + LLNM, less intensive treatment should be considered.
Fluctuations in Metabolites and Bone Markers Across the Menstrual Cycle in Eumenorrheic Women and Oral Contraceptive Users
Authors: He Weiwei , Dam Tine Vrist , Thøgersen Rebekka , Hansen Mette , Bertram Hanne Christine 
Published: February 2022

AbstractContextLittle is known about changes in circulating metabolites during the menstrual cycle and how use of oral contraceptives (OCs) affects these changes.ObjectivesTo study fluctuations in circulating metabolite and bone marker levels during the menstrual/pill cycle in eumenorrheic women and OC users.MethodsPlasma samples were collected from 28 eumenorrheic women and 10 OC users at 7 to 9 time points across a menstrual/pill cycle. Longitudinal and cross-sectional analyses were performed to examine the cycle- and OC-induced variations in the plasma metabolite and bone turnover marker levels.ResultsIn eumenorrheic women, plasma levels of alanine, glutamine, threonine, and tyrosine varied significantly across the menstrual cycle, and all dropped to the lowest level around day 21 of the menstrual cycle. These amino acid concentrations were negatively correlated with fluctuations in progesterone and/or estrogen levels. A between-group analysis showed that plasma levels of alanine, glutamine, glycine, proline, and tyrosine were lower in OC users than in nonusers. Concomitantly, plasma C-terminal telopeptide of type I collagen (CTX) and N-terminal propeptide of type I procollagen (PINP) levels were lower in OC users. Intriguingly, when all data were pooled, variations in CTX and PINP levels were positively correlated with fluctuations in proline and glycine concentrations (r &gt; 0.5 or 0.3 &lt; r &lt; 0.5, P &lt; 0.05).ConclusionsThe menstrual cycle and the use of OCs alter plasma levels of metabolites and bone turnover markers in young women. While the impact of these findings remains to be established, the lower glycine level among OC users and the accompanying lower CTX level supports that the use of OCs lowers collagen turnover in young women and may thereby have long-term implications for bone health among OC users.
Wireless Single-Lead ECG Monitoring to Detect New-Onset Postoperative Atrial Fibrillation in Patients After Major Noncardiac Surgery: A Prospective Observational Study
Authors: Jokinen Johan D. V. , Carlsson Christian J. , Rasmussen Søren M. , Nielsen Olav W. , Winkel Bo G. , Jorgensen Lars N. , Achiam Michael P. , Mølgaard Jesper , Sørensen Helge B. D. , Aasvang Eske K. , Meyhoff Christian S. ,   for the WARD Project Group
Published: February 2022

BACKGROUND:
New-onset postoperative atrial fibrillation (POAF) is associated with several cardiovascular complications and higher mortality. Several pathophysiological processes such as hypoxia can trigger POAF, but these are sparsely elucidated, and POAF is often asymptomatic. In patients undergoing major gastrointestinal cancer surgery, we aimed to describe the frequency of POAF as automatically estimated and detected via wireless repeated sampling monitoring and secondarily to describe the association between preceding vital sign deviations and POAF.

METHOD:
Patients ≥60 years of age undergoing major gastrointestinal cancer surgery were continuously monitored for up to 4 days postoperatively. Electrocardiograms were obtained every minute throughout the monitoring period. Clinical staff were blinded to all measurements. As for the primary outcome, POAF was defined as 30 consecutive minutes or more detected by a purpose-built computerized algorithm and validated by cardiologists. The primary exposure variable was any episode of peripheral oxygen saturation (Spo
2) <85% for >5 consecutive minutes before POAF.

RESULTS:
A total of 30,145 hours of monitoring was performed in 398 patients, with a median of 92 hours per patient (interquartile range [IQR], 54–96). POAF was detected in 26 patients (6.5%; 95% confidence interval [CI], 4.5–9.4) compared with 14 (3.5%; 95% CI, 1.94–5.83) discovered by clinical staff in the monitoring period. POAF was followed by 9.4 days hospitalization (IQR, 6.5–16) versus 6.5 days (IQR, 2.5–11) in patients without POAF. Preceding episodes of Spo
2 <85% for >5 minutes (OR, 1.02; 95% CI, 0.24-4.00; P = .98) or other vital sign deviations were not significantly associated with POAF.

CONCLUSIONS:
New-onset POAF occurred in 6.5% (95% CI, 4.5–9.4) of patients after major gastrointestinal cancer surgery, and 1 in 3 cases was not detected by the clinical staff (35%; 95% CI, 17–56). POAF was not preceded by vital sign deviations.
Queer Allusion: Wilde, Housman, Cullen
Authors: Gargaillo Florian 
Published: February 2022

AbstractThis essay argues for the distinctive role of allusion in queer poetry of the pre-Stonewall era, using the work of Oscar Wilde, A. E. Housman, and Countee Cullen as case studies. Most allusions depend on implicit verbal echoes that can be identified by readers able and willing to recognize them. That mix of secrecy and openness was especially attractive to gay poets, since it enabled them to express their desires obliquely by writing through authors who hinted at similar experiences. Queer allusion thus offers an alternative to long-standing theories of influence that describe poetry’s relationship to the past in terms of debt or competition. Unlike these models, queer allusion allowed poets to foster connections on the page and find relief from the loneliness that was endemic to gay life.
“Les Hommes ont toute l’autorité”
Authors: Herdman Emma 
Published: February 2022

AbstractA Renaissance querelle was primarily litigious. As such, it was heavily gendered: women, who were culturally expected to be conciliatory, not argumentative, were excluded from the law courts. This article uses the example of Madeleine des Roches—a widow, and so legally “capable,” like her unmarried daughter, Catherine—to consider how women negotiated the challenges of legal quarreling. It analyzes the strategies des Roches employed, in her poetry and in her published correspondence, to avoid being perceived as quarrelsome, to bind her judicially influential addressees in obligation to her, and to object to women’s exclusion from the law. It thus shows how des Roches’s references to the court cases that plagued her widowhood actively engaged both with the individual quarrels of these specific cases and with a more general quarrel with the injustices of an exclusive and often obstructive process of law. Des Roches’s rejection of overtly agonistic writing in favor of discreetly powerful methods of persuasion reflects her objection to quarreling—as an unwelcome distraction from the literary self-expression that she maintains is a woman’s intellectual right—even as she engaged with both the law courts and the querelle des femmes.
Antoinette Deshoulières’s Cat
Authors: Taylor Helena 
Published: February 2022

AbstractThis article examines the poet Antoinette Deshoulières’s (1638–94) interventions in a number of querelles. It focuses on a series of poems that appeared in 1678–79, early in her career, and written as if from her pet cat. Often dismissed for their frivolity, these poems instead reveal Deshoulières’s engagement with the Quarrel of the Ancients and Moderns and the debates about the animal machine. While such interventions constituted an important strategy for making a name for herself, they are characterized by elusiveness. Although that elusiveness has been read as a gendered strategy of modesty, this article shows instead that her equivocal and even parodic, burlesque way of intervening in the two quarrels is consistent with her skepticism and presents readers with a hermeneutical challenge that disrupts the rhetorical logic of a quarrel. Deshoulières’s interventions invite us to reflect on the roles of gender, genre, and interpretation in early modern quarrels and their study.
A Woman’s Words
Authors: Seth Catriona 
Published: February 2022

Abstract
Right at the end of the eighteenth century, a famous poet, Ponce-Denis Écouchard Le Brun, denounced women writers and a literary dispute ensued. While it mobilized a number of authors, one poem stands out in accounts of the quarrel: Constance Pipelet’s “Épître aux femmes.” A study of the timeline shows that this was not in fact part of the original exchanges and that its central role is due on the one hand to a retrospective delineation of the events by a woman poet with a vested interest and, on the other, to its ambition and quality. The case poses several questions around authorial identity, gender-based judgments, the role of periodicals, and the literary construction of quarrels both as they occur and after they are over.
Becoming Mutant
Authors: Mattson L. D. , Gordon Jeremy 
Published: February 2022

Abstract
Reimagining human-nature relationships in the climate change era conjures mutants, creatures from the deep that help surface modes of becoming for a drenched world of rising tides, plastic oceans, and soaked cities. Re-imaging deep, embodied relations with watery ecologies, then, also involves attention to speculative climate fictions (cli-fi) and the potential worlds they help fathom. Cli-fi renderings of climate disaster provide critical insight into possible alternative arrangements of power, meaning, and ontological status. As such, this article explores the depths of the 1995 cli-fi film Waterworld, offering an ecocritical analysis of how the film’s mutant imaginary might help us fathom how to flourish amid floods and contest the very human forces/forms that shape them. In Waterworld, the authors find queer elemental bodies collaborating with ecology and embracing their inherent impurities. This classic cli-fi film provides an important touchstone for a future in which dominant petro-masculine approaches to pelagic place are found to be drowned, dead ends. This article amplifies how mutant corporeal formations and elemental agencies in Waterworld swirl together to submerge systems of power and privilege and drench binaries. Ultimately, Waterworld’s queer ecology helps morph what and how it means to live in a flooded future as speculative seascapes seep into everyday contemporary climate life.
The Bestiary in the Candy Aisle
Authors: McCumber Andrew , Dryden Patrick Neil 
Published: February 2022

AbstractArchaeology and anthropology treat the presence of animals in mythology and folklore as axiomatically about a culture’s ideas of nature. Sociology often assumes modernity no longer has such myths, but animal imagery abounds. In this article, the authors argue that our relationships with animals and nature are not primarily rational or scientific but formed through these images and the mythologies that come with them. The authors call these images “modern bestiaries” in reference to the medieval proto-encyclopedias that cataloged animals for moral instruction. Modern bestiaries (including alphabet books, sports teams, and car names, among others) generate a holistic worldview that marries a deep love of animals and “nature” to a fundamentally anti-ecological cosmology. The authors examine a particular modern bestiary—the menagerie of gummi animals in the candy aisle. Eating a gummi bear is never merely gastronomic but also an act of mimesis, sympathetic magic, and storytelling in which cultural relationships to animals are formed.
“The Great Chain of Being Come Undone”
Authors: McRae Calista 
Published: February 2022

AbstractThis review essay explores three recent academic studies situated at the intersection of Black studies and animal studies: Joshua Bennett’s Being Property Once Myself: Blackness and the End of Man, Bénédicte Boisseron’s Afro-Dog: Blackness and the Animal Question, and Zakiyyah Iman Jackson’s Becoming Human: Matter and Meaning in an Antiblack World. As these books make clear, wide-ranging possibilities can emerge when one reads Blackness and animals together. Each author finds ways of reexamining the human-animal divide, of calling into question other labels and hierarchies, of seeing subjectivity and vitality and resilience where blankness or death or limit have usually been the standard terms. Their work marks the beginning of what we can expect will be a wave of scholarship offering correctives to past silence and simplifications.
Synthesis and Optical/Electronic Properties of Imitation-copper Crystals Based on Low-molecular Azobenzene Derivatives
Authors: Onodera Katsuki , Saito Norio , Kondo Yukishige 
Published: February 2022

Abstract
Three imitation-copper compounds were synthesized from low-molecular azobenzene derivatives: 4-(3-methylbutoxy)-4′-cyanoazobenzene (NC-azo-DC), 4-(3-methylbutoxy)-4′-nitroazobenzene (NO2-azo-DC), and 1,4-bis[4′-(3-methylbutoxy)phenylazo]benzene (Bis-DCazo). Each compound crystallized with large plate-like planar faces. Copper-colored luster was attained using filtration to accumulate the planar crystals. Specular reflection spectroscopy and calculations indicate the reddish color was enhanced by extending π-conjugation of the azobenzene phenyl rings. These imitation-copper compounds were facilely synthesized and metal free, and did not exhibit electronic conductivity, making them promising substitutes for conventional metal-based lustrous pigments and dyes.
Similar and specific immunotropic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats
Authors: Badiuk Nataliya , Popovych Dariya , Hrytsak Myroslava , Ruzhylo Sofiya , Zakalyak Nataliya , Kovalchuk Galyna , Mel’nyk Oksana , Zukow Xawery 
Published: February 2022

Background. Earlier in an experiment on rats, we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa has a significant modulating effect on the parameters of metabolism and the autonomic nervous and endocrine systems. In this study, conducted in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum, data on the immunomodulatory effects of these waters on the same rats. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 230-290 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the second (control) group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The object of the study were the immune parameters of the thymus, spleen and blood. Results. The method of discriminant analysis revealed 12 parameters, according to which the animals loaded with mineral waters differed significantly from both control and intact animals. Classification accuracy is 86%. However, the difference between the immunotropic effects of mineral waters of different mineralization concerns only 9 parameters. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have both similar and specific immunomodulating effects on healthy old female rats with weekly use. This provides a basis for preclinical studies.
N-polar InGaN/GaN nanowires: overcoming the efficiency cliff of red-emitting micro-LEDs
Authors: Pandey A. , Malhotra Y. , Wang P. , Sun K. , Liu X. , Mi Z. 
Published: February 2022

A high efficiency, high brightness, and robust micro or sub-microscale red light emitting diode (LED) is an essential, yet missing, component of the emerging virtual reality and future ultrahigh resolution mobile displays. We report, for the first time, to our knowledge, the demonstration of an N-polar InGaN/GaN nanowire sub-microscale LED emitting in the red spectrum that can overcome the efficiency cliff of conventional red-emitting micro-LEDs. We show that the emission wavelengths of N-polar InGaN/GaN nanowires can be progressively shifted from yellow to orange and red, which is difficult to achieve for conventional InGaN quantum wells or Ga-polar nanowires. Significantly, the optical emission intensity can be enhanced by more than one order of magnitude by employing an in situ annealing process of the InGaN active region, suggesting significantly reduced defect formation. LEDs with lateral dimensions as small as

∼
0.75

μm

, consisting of approximately five nanowires, were fabricated and characterized, which are the smallest red-emitting LEDs ever reported, to our knowledge. A maximum external quantum efficiency

∼
1.2
%

was measured, which is comparable to previously reported conventional quantum well micro-LEDs operating in this wavelength range, while our device sizes are nearly three to five orders of magnitude smaller in surface area.
Incidence and predictors of severe acute malnutrition mortality in children aged 6–59 months admitted at Pawe general hospital, Northwest Ethiopia
Authors: Kebede Fassikaw , Kebede Tsehay , Negese Belete , Abera Atitegeb , Fentaw Getahun , Kasaw Ayalew 
Published: February 2022

Background
Severe acute malnutrition (SAM) is defined as a weight-for-height < -3z scores of the median WHO growth standards, or visible severe wasting or the presence of nutritional edema. SAM related mortality rates in under-five children are well documented in Ethiopia but data on their predictors are limited. We aimed to document factors associated with SAM related mortality to inform better inpatient management.

Methods
A facility-based retrospective cohort study was conducted among children admitted due to SAM at Pawe General Hospital, Northwest Ethiopia, from the 1st of January 2015 to the 31st of December 2019. Data from the records of SAM children were extracted using a standardized checklist. Epi-Data version 3.2 was used for data entry, and Stata version 14 was used for analysis. Bi-variable and multivariable Cox regression analyses were conducted to identify predictors of mortality. Variables with P<0.05 were considered significant predictors of mortality.

Results
Five-hundred sixty-eight SAM cases were identified of mean age was 27.4 (SD± 16.5) months. The crude death rate was 91/568 (16.02%) and the mean time to death was determined as 13 (±8) days. Independent risk factors for death were: (i) vomiting AHR = 5.1 (1.35–21.1, p = 0.026), (ii) diarrhea AHR = 2.79 (1.46–5.4, p = 0.002), (iii) needing nasogastric therapy AHR = 3.22 (1.65–6.26, p = 0.001), (iv) anemia AHR = 1.89 (1.15–3.2, p = 0.012), and (v) being readmitted with SAM AHR = 1.7 (1.12–2.8, p = 0.037).

Conclusion
SAM mortality was high in under-five children in our setting. The identified risk factors should inform treatment and prevention strategies. Improved community health education should focus on healthy nutrition and seeking early treatment. Inpatient mortality may be reduced by stricter adherence to treatment guidelines and recognizing early the key risk factors for death.