bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catalytic NO Reduction by NO Pre‐Adsorbed RhCeO2NO−Clusters
Authors: Chen Jiao‐Jiao , Liu Qing‐Yu , Wang Si‐Dun , Li Xiao‐Na , He Sheng‐Gui 
Published: October 2022

AbstractA fundamental understanding on the dynamically structural evolution of catalysts induced by reactant gases under working conditions is challenging but pivotal in catalyst design. Herein, in combination with state‐of‐the‐art mass spectrometry for cluster reactions, cryogenic photoelectron imaging spectroscopy, and quantum‐chemical calculations, we identified that NO adsorption on rhodium‐cerium bimetallic oxide cluster RhCeO2−can create a Ce3+ion in product RhCeO2NO−that serves as the starting point to trigger the catalysis of NO reduction by CO. Theoretical calculations substantiated that the reduction of another two NO molecules into N2O takes place exclusively on the Ce3+ion while Rh behaves like a promoter to buffer electrons and cooperates with Ce3+to drive NO reduction. Our finding demonstrates the importance of NO in regulating the catalytic behavior of Rh under reaction conditions and provides much‐needed insights into the essence of NO reduction over Rh/CeO2, one of the most efficient components in three‐way catalysts for NOxremoval.
Formation of multiple anodic fire spots inside an electrostatic cavity
Authors: Bose Subhojit , Debnath Arpan , Paul Manash Kumar 
Published: October 2022

AbstractCharged particles exhibit self‐organized behaviour during the discharge state transitions inside an electrostatic cavity, along with the energy redistribution in different coherent modes with progressive anode potential. Multiple sheath formations around the spherical metallic ball anode placed inside the cavity transit to intensely glowing multiple anode spot formations (fireballs) on the anode surface with progressive anode potential. The intensely glowing anode spots reorganize over the anode surface and multiply quickly on increasing the anode potential. The nonlinear analysis of the fluctuating discharge current reveals the presence of self‐organized criticality (SOC) during different states of discharge along with a strong memory effect within (10–104) time lags in every state of discharge. The multiple anode spots exhibit long‐range correlation in the absence of a magnetic field, indicating SOC behaviour. The present study investigates energy distribution among the coherent modes of discharge through the application of the Empirical Mode Decomposition technique. The analysis indicates that the introduction of a magnetic field results in the interchange of coherent modes carrying most of the energy during multiple spot formations. The present experimental configuration produces stable multiple coherent modes along with the evolution of anodic sheath layers in the absence and then in the presence of the magnetic field. Relating SOC with such discharge transitions may help to understand the relation between complex structure formations in plasma with nonlinear aspects of glow discharge, which is of vital importance in the investigation of complexities in space plasma.
Type 1 diabetes recurrence after SARS‐CoV‐2 infection in a subject with pancreas transplantation
Authors: Popolla Valentina , Rizzi Alessandro , Tartaglione Linda , Pontecorvi Alfredo , Pitocco Dario 
Published: October 2022

AbstractBackgroundDuring COVID‐19 pandemic, several studies have demonstrated a strong link between SARS‐CoV‐2 infection and diabetes mellitus. Hyperglycaemia is a frequent event during the infection, also in patients without a history of diabetes. Furthermore, several cases of diabetic ketoacidosis during COVID‐19 disease have been described. No data are available about the effects of SARS‐CoV‐2 infection on glycaemic control in pancreas transplant patients.Case presentationA 45‐year‐old woman affected by type 1 diabetes mellitus was treated with kidney‐pancreas transplantation in 2015, 6 years before COVID‐19 infection. After transplantation, insulin therapy was stopped with a good glycaemic control during the following years.After SARS‐CoV‐2 infection, she developed severe hyperglycaemia requiring insulin therapy again. During the acute phase of the infection, the detection of antibodies against islet cells (ICA) and against glutamic acid decarboxylase (GAD) was found positive.ConclusionsThe onset of hyperglycaemia after SARS‐CoV‐2 infection might be the result of a direct virus‐induced toxicity or the effect of a virus‐mediated activation of autoimmunity.
HMG‐CoA reductase inhibition medicated hypocholesterolemic and antiatherosclerotic potential of phytoconstituents of an aqueous pod extract of Prosopis cineraria (L.) Druce: In silico, in vitro, and in vivo studies
Authors: Jaipal Noopur , Ram Heera , Charan Jaykaran , Dixit Anshuman , Singh Garima , Singh Bhim P. , Kumar Ashok , Panwar Anil 
Published: October 2022

AbstractHydrophilic bioactive compounds are copiously exhibited in aqueous extracts owed to solubility. The study was assigned to assess the ability of phytoconstituents of aqueous pod extract of Prosopis cineraria to inhibit 3‐hydroxy‐3‐methylglutary‐coenzyme A (HMG‐CoA) reductase activity and regression in atherosclerotic plaque through in vitro, in vivo, and in silico assessments along with phytochemistry of extract. The test extract exhibited 17 leading compounds as examined by Liquid Chromatograph Triple Quadrupole Mass Spectroscope. In vitro assay of test extract showed 78.1% inhibition of HMG‐CoA inhibition (IC50 was 0.03 μg/ml). In vivo assessments, hypercholesterolemia was induced by supplementing cholesterol powder and a high‐fat diet. The treatment of test extract caused significant (p ≤ 0.001) improvements in the lipid profile and antioxidant levels. Subsequently, the reductions in the atherosclerotic plaque and improved lumen volume were pointedly observed. In silico analyses of molecular docking revealed potent interaction capabilities of cloprostenol with the target protein of HMGR. The interactions were validated through structural simulations of the molecular dynamics such as root mean square fluctuation, the radius of gyration, and solvent accessible surface area. The druggability of potent compounds was also examined. The results revealed that phytoconstituents of the test extract could inhibit HMGR and regress atherosclerotic plaque.
German physicians' expectations of healthcare management companies: An exploratory study
Authors: Oberschachtsiek Dirk , Ehlert Andree 
Published: October 2022

AbstractBackground and aimsEven 20 years after the introduction of managed care (MC) in Germany, many physicians are skeptical of the concept, hindering its acceptance.MethodsBased on multivariate statistical methods this exploratory study examines how so‐called management companies, that is, administrative service providers within MC contracts, can increase physicians' acceptance of MC by offering, for example, day‐to‐day coordination and administrative tasks.ResultsAs a main empirical result, we find support for this hypothesis, that is, that certain physicians evaluate their MC participation according to its prospective administrative support. Based on this, up to four clusters of physicians can be statistically identified in terms of their preferences regarding MC.ConclusionAs a policy recommendation, we derive from our results that a future focus on the administrative support components of MC is essential to attract certain physician groups to participate in MC.
Depression, anxiety, and performance status among the women with metastatic breast cancer receiving palliative care in Bangladesh: A cross sectional study
Authors: Islam Nashid , Biswas Jheelam , Kowshik Mostofa Monwar , Molla Md Maruf Ahmed , Sarker Mridul , Chowdhury Mostofa Kamal , Bhuiyan AKM Motiur Rahman , Ahmad Nezamuddin 
Published: October 2022

AbstractBackground and AimsAdvanced breast cancer patients suffer from various psychological issues including depression and anxiety. This study aims to explore these psychological issues and their relationship with the performance status.MethodsThis cross‐sectional study was conducted among 95 patients with metastatic breast cancer attending the Department of Palliative Medicine, Bangabandhu Sheikh Mujib Medical University, Bangladesh from April 2021 to September 2021. Data was collected by face‐to‐face interview using a structured questionnaire along with Hospital Depression and Anxiety Scale. The performance status of the patients was determined by the Eastern Cooperative Oncology Group (ECOG) performance scale. The association between different variables were assessed by χ2 test and Fisher Exact test.ResultMean age of the respondents was 48.9 ± 9.9 years. Most of them were married (94.7%), muslim (92.6%) and homemakers (82.1%). More than half (52.6%) of the patients were evaluated having ECOG performance status grade II. Four out of ten (44.2%) patients had moderate to severely anxiety, and almost one‐third (36.9%) patients were suffering from moderate to severe depression. The patients with high educational status were found to have less depression. In addition, patients faring better on ECOG performance scale (Grade 0 to I) had significantly (p < 0.05) less depression and anxiety.ConclusionDepression and anxiety are one of the major psychological sufferings among the women with metastatic breast cancers. All women suffering from breast cancer should be routinely screened and assessed for phychological distress and ensure early intervention.
Identifying unmet information needs of advanced cancer patients in Iran: An in‐depth qualitative study
Authors: Amiri Parasto , Mohammadi Ali , Bahaadinbeigy Kambiz , Kalantari Khandani Behjat , Maazed Vahid 
Published: October 2022

AbstractBackground and AimsOne of the main vital needs for self‐care in patients with advanced cancer is information need. Meeting this need has significant positive effects on improving their treatment and care. This study was conducted to identify the unmet information needs of patients with advanced cancer in Iran.MethodsThis exploratory study was performed from July to February 2021 in the Kerman University of Medical Sciences cancer treatment centers. Oncologists selected eligible patients by purposeful sampling method. Semistructured and in‐depth interviews were conducted with selected patients to collect data. Interviews continued until data saturation. Each interview was audio‐recorded and transcribed verbatim.ResultsIn the interviews, 15 patients with advanced cancer ranging in age from 43 to 65 years participated. The most common type of cancer in women was breast (71.4%) and prostate (50%) in men. The two main categories of “types of unmet information needs” and “reasons for not meeting information needs” were extracted from the analysis of patient interviews, with six and four subcategories, respectively.ConclusionCancer patients had a large number of unmet information needs. At the time of identifying the unmet information needs of cancer patients, the basic reasons for not meeting these needs should also be considered because cultural differences and social gaps in societies are inevitable.
Effect of inpatient experiences on patient satisfaction and the willingness to recommend a hospital: The mediating role of patient satisfaction: A cross‐sectional study
Authors: Park Hye Na , Park Do Joong , Han Se Young , Tae Ji Yeon , Jung Keun‐Hwa , Bae Eun Jung , Yoon Ju Young 
Published: October 2022

AbstractBackground and AimsAs high‐quality health care encompasses patient‐centered care, this study used the perceived quality−satisfaction−behavioral intention and structure‐process‐outcome models to (1) investigate the relationships among patient experience, patient satisfaction, and the willingness to recommend a hospital and (2) estimate the indirect effects of patient satisfaction on the relationship between patient experience and the willingness to recommend a hospital.MethodsA cross‐sectional survey design was adopted to investigate data obtained from the Seoul National University Hospital Patient Experience survey administered in 2020. Responses were analyzed from 1555 patients, who had been admitted to the inpatient ward of a tertiary hospital for a period lasting more than 1 day.ResultsThe path model demonstrated a good fit to the relationships between patient experience, patient satisfaction, and the willingness to recommend the hospital. Patient experience directly influenced patient satisfaction (β = 0.659, p < 0.001) and the willingness to recommend the hospital (β = 0.168, p < 0.001), whereas patient satisfaction had an indirect effect (β = 0.418, p < 0.001) on the relationship between patient experience and the willingness to recommend the hospital.ConclusionPatient experience is a critical factor that health care systems need to consider for enhancing patient‐centeredness, patient satisfaction, and the willingness to recommend a hospital.
Role of extracellular vesicles in mitochondrial eye diseases
Authors: Anand Sushma , Trounce Ian A. , Gangoda Lahiru 
Published: October 2022

AbstractExtracellular vesicles (EVs) are small packages that are released by almost all types of cells. While the role of EVs in pathogenesis of certain diseases such as cancer is well established, EVs role in ocular health and disease is still at early stages of investigation. Given the significant role of EVs in pathological development and progression of diseases such as cancer, EVs present a similar opportunity for investigation in ocular pathophysiology. Studies have shown the presence of EVs in fluids from the ocular environment have close links with ocular health and disease. Hence, the cargo carried in EVs from ocular fluids can be used for monitoring disease phenotypes or therapeutic outcomes in eye‐related disorders. Furthermore, in recent times EVs have increasingly gained attention as therapeutics and drug‐delivery vehicles for treatment of eye diseases. There is a close relationship between EVs and mitochondria functioning with mitochondria dysfunction leading to a significant number of ophthalmic disorders. This review discusses the current knowledge of EVs in visual systems with a special focus on eye diseases resulting from dysfunctional mitochondria.
Multiliterate lives: Childhood to adult, lessons learned
Authors: Wood Jeffrey , Peters Emily , Wood Tristan , Wood Simon 
Published: October 2022

AbstractThis retrospective is a group effort between my children and me to make sense of their literacies over the past 26 years. Sharing in the authoring of this retrospective, we take a look back at the ways those literacies unfolded across their childhood. Emily, Tristan, and Simon used different literacies to define who they were and to construct a literate ethos. They each engaged with literacies in powerful and life transforming ways. They used multiple literacies together to help them learn, understand and create meaning more fully. Their stories demonstrate the need for young children to engage with multiple literacies to fully develop as literate adults. This retrospective supports the idea that literacies are complex, motivated, multimodal, semiotic, social, discourse dependent, and imbedded in specific practices.
Development and validation of multiresidue method for organophosphorus pesticides in lanolin using gas chromatography–tandem mass spectrometry
Authors: Gupta Neha , Singh Rakhi , Nayak Sumant Kumar , Das Mukul , Jan Kulsum 
Published: October 2022

AbstractLanolin, also known as wool wax, is derived from sheep and has diverse applications in food, cosmetic, textile and lubricant industries. Owing to its direct contact with human, there is a need of studying pesticide residues as contaminants in lanolin. The present study describes a single novel hyphenated gas chromatography–tandem mass spectrometry (GC‐MS/MS) technique for the quantification of 14 organophosphorus (OP) pesticides (tecnazene, propetamphos, diazinon, dichlofenthion, chlorpyrifos methyl, fenchlorphos, malathion, chlorpyrifos, pirimiphos ethyl, bromophos ethyl, tetrachlorvinphos, ethion, phosalone, and coumaphos) in lanolin using electrospray ionization (EI) with multiple reaction monitoring (MRM) acquisition mode. The method is simple in terms of sample preparation steps based on matrix solid‐phase dispersion (MSPD). The method was found to be linear over the analytical range of 0.05–2.0 μg/g, with acceptable coefficient of determination (r2 ≥ 0.99) for all the 14 pesticides. The limit of detection (LOD) and limit of quantification (LOQ) of the method were found to be less than 0.05 and 0.1 μg/g, respectively, for all the 14 OP pesticide residues. The precision and accuracy of the method were found to be within the acceptable limits, that is, recoveries in the range of 83.5%–104.1% with less than 12.5% of relative standard deviation for all the pesticides. The multiresidue method for estimating pesticide residues employing GC‐MS/MS technique will be useful for OP pesticide levels in large number of lanolin samples.
Catheter ablation in patients with atrial fibrillation and heart failure with preserved ejection fraction: A systematic review and meta‐analysis
Authors: Siddiqui Muhammad U. , Junarta Joey , Riley Joshua M. , Ahmed Adnan , Pasha Ahmed K. , Limbrick Kolin , Alvarez Rene J. , Frisch Daniel R. 
Published: October 2022

AbstractBackgroundCatheter ablation for atrial fibrillation (AF) is a proven alternative to pharmacologic rhythm control in patients with heart failure with reduced ejection fraction (HFrEF). Whether outcomes differ in patients with heart failure with preserved ejection fraction (HFpEF) is of interest.MethodsMedline, Scopus, and Cochrane Central Register of Controlled Trials were systematically searched to identify relevant studies. Primary efficacy outcomes of interest include atrial arrythmia recurrence and repeat ablation. Harm outcomes of interest include all‐cause mortality, all‐cause hospitalizations, cardiovascular hospitalizations, stroke/transient ischemic attack, and cardiac tamponade.ResultsWe included 7 observational studies comprising 2554 patients with HFpEF who underwent catheter ablation for AF. When comparing patients with HFpEF versus without HF, there was no significant difference in atrial arrhythmia recurrence (risk ratio [RR] 1.39; 95% confidence interval [CI] 0.91–2.13), stroke or transient ischemic attack (TIA) (RR 0.47; 95% CI 0.03–6.54), or cardiac tamponade (RR 1.20; 95% CI 0.12–12.20). When comparing patients with HFpEF versus HFrEF, there was no significant difference in atrial arrhythmia recurrence (RR 1.12; 95% CI 0.92–1.37), repeat ablation (RR 1.19; 95% CI 0.74–1.93), all‐cause mortality (RR 0.87; 95% CI 0.67–1.13), all‐cause hospitalizations (RR 1.10; 95% CI 0.94–1.30), cardiovascular hospitalizations (RR 0.83; 95% CI 0.69–1.01), stroke or TIA (RR 0.81; 95% CI 0.29–2.25), or cardiac tamponade (RR 0.98; 95% CI 0.19–5.16).ConclusionsNon‐randomized studies suggest that catheter ablation for AF in patients with HFpEF is associated with similar arrythmia‐free survival and safety profile when compared to patients with HFrEF or without heart failure.
Incidence and development of cholestasis in surgical neonates receiving an intravenous mixed‐oil lipid emulsion
Authors: Yu Lumeng J. , Anez‐Bustillos Lorenzo , Mitchell Paul D. , Ko Victoria H. , Secor Jordan D. , Hurley Alexis P. , Dao Duy T. , Fligor Scott C. , Cho Bennet S. , Tsikis Savas T. , Gura Kathleen M. , Puder Mark 
Published: October 2022

AbstractBackgroundIntestinal failure–associated liver disease (IFALD), initially manifesting as cholestasis, is a complication in neonates receiving parenteral nutrition (PN). Soybean oil lipid emulsion (SOLE), though implicated in IFALD, was the only US Food and Drug Administration (FDA)–approved initial intravenous lipid emulsion (ILE) for infants and children in the United States. A mixed‐oil lipid emulsion (MOLE) gained popularity in patients at risk for IFALD and was recently FDA approved as an initial ILE in children. Given the presence of soybean oil in MOLE, we hypothesized that MOLE would not be effective at preventing cholestasis in surgical neonates.MethodsNeonates with gastrointestinal surgical conditions necessitating PN for ≥14 days and receiving MOLE (SMOFlipid) from July 2016 to July 2019 were analyzed retrospectively. Unpaired and pair‐matched historical surgical neonates treated with SOLE (Intralipid) served as controls. The primary outcome measure was development of cholestasis (direct bilirubin ≥2 mg/dl).ResultsOverall, 63% (10 of 16) of MOLE patients and 22% (30 of 136) of SOLE patients developed cholestasis after ≥14 days of therapy (P = 0.005). The latency to developing cholestasis was significantly shorter in MOLE patients compared with SOLE patients.ConclusionIn surgical neonates, MOLE may not prevent cholestasis and should not be considered hepatoprotective. Regardless of ILE source, all surgical neonates should be closely monitored for development of IFALD. To date, there is still no ILE able to prevent IFALD.
Fruit growth, carbon allocation, and related enzymes in tomato under different irrigation and potassium application regimes
Authors: Wu Changlong , Zhang Xinsheng , Zhou Chenni , Luo Anrong 
Published: October 2022

AbstractBackgroundThe increasing concentration of atmospheric CO2 not only affects the growing environment of crops but also aggravates the global greenhouse effect and further aggravates the problem of water shortage. The combined effect of water deficit and potassium (K) application has not been widely studied.AimsA pot experiment was conducted to investigate the effect of deficit irrigation (DI) and K application at different growth stages on carbon allocation and enzyme activities related to sugar metabolism.MethodsTomatoes were transplanted and planted on April 26, 2017 and harvested on August 15, 2017. Four irrigation regimes were implemented with two water levels (full irrigation‐W and DI‐W/2) in different growth stages, and each water treatment was equally divided into two subgroups: with K (K1) and without K (K0). Fruits from the first to fourth trusses of the tomato plants were sampled. Tomato growth, carbon allocation, and related enzyme activities were measured.ResultsThe fresh weight (FW), dry weight, and relative growth rate of dry mass were sensitive to irrigation amount under K fertilization, enhancing the promotion effect of irrigation on fruit. Meanwhile, carbon allocation was sensitive to irrigation amount under K regime. Sucrose synthase (SuSy), acid invertase (AI), and sucrose phosphate synthase (SPS) were also highly sensitive to irrigation amount under K application condition. Starch phosphorylase displayed a quadratic parabola for irrigation amount, and adenosine diphosphate glucose pyrophosphorylase (AGPase) was highly sensitive to irrigation amount without K fertilization. Carbon in the form of other carbohydrates, carbon in the form of soluble sugar (Csol), and fruit water content were the factors that had the greatest influence on the principal components. Classification by K‐means algorithm and canonical correlation analysis showed that FW, fructose, sucrose, and starch could be used as significant indicators of the dry matter components of the fruit for the treatment without K. In the case of K regime, SuSy, AGPase, AI, and Csol could be used as a significant indicator of the correlation analysis of carbon metabolism activity.ConclusionsThe factors related to the improvement of fruit quality and carbon allocation by deficient irrigation and K application were explored. Water stress changed the distribution of photosynthetic carbon between starch and soluble sugar. K application further changed the balance between soluble sugars and other compounds. In particular, it significantly increased the carbon content of soluble sugars and decreased that of other compounds. AI and SuSy are key enzymes affecting carbon metabolism under water‐deficient conditions.