bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of adding bevacizumab biosimilar or original drug to platinum-based chemotherapy as first-line treatment in patients with advanced NSCLC: a systematic review and meta-analysis
Authors: Yang Liu , Liu Maobai , Cao Xueqiong , Li Na , Zheng Bin , Deng Jianhao , Cai Hongfu 
Published: October 2022

Introduction: The role of bevacizumab combined with paclitaxel and carboplatin in the first-line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) has been supported by a large number of data. However, whether bevacizumab biosimilars have the same efficacy and safety as the original drug is still controversial. This meta-analysis was designed to evaluate whether bevacizumab biosimilars have the same clinical efficacy and safety as the original drug in patients with advanced non-squamous NSCLC. Methods: Electronic databases (PubMed, Embase, Cochrane, CNKI, Wanfang, and VIP) and the ClinicalTrail.gov website were extensively searched using relevant search criteria. We included phase III randomized controlled trials (RCTs) to compare the efficacy and safety of marketed biosimilars and Avastin in the first-line treatment of patients with advanced NSCLC. The risk of bias of the included studies was assessed using the RoB 2 assessment scale, and the RevMan 5.4 statistical software was used for meta-analysis. Results: A total of 6360 patients were included in 11 RCTs. There was no statistical difference between the experimental group and the control group in terms of effectiveness [objective response rate (at week 18), disease control rate (at week 18), median duration of response, median progression-free survival, median overall survival (OS), and OS after 12 months]. In terms of safety [treatment-emergent adverse events (grade ⩾3) and treatment-related adverse events (grade ⩾3)], there was also no significant difference between biosimilars and Avastin. Conclusions: The efficacy and safety of bevacizumab biosimilars in the treatment of advanced non-squamous NSCLC are highly similar to those of the original drug combined with paclitaxel and carboplatin, respectively.
Correlation between T stage and lymph node metastasis in rectal cancer treated with preoperative chemoradiotherapy
Authors: Kim Seijong , Huh Jung Wook , Lee Woo Yong , Yun Seong Hyeon , Kim Hee Cheol , Cho Yong Beom , Park Yoonah , Shin Jung Kyong 
Published: October 2022

Background: Depth of tumor is a risk factor for lymph node metastasis in rectal cancer, but impact of yield pathologic T (ypT) stage on lymph node involvement in rectal cancer remains unclear. The aim of this study was to evaluate the correlation between ypT stage and lymph node metastasis. Methods: From January 2010 to December 2015, 602 patients who were diagnosed with rectal cancer and treated with neoadjuvant chemoradiotherapy (CRT) followed by radical operation were reviewed retrospectively. The correlations between ypT stage and lymph node status and survival were evaluated. Results: On pathology, 179 (29.7%) patients exhibited regional lymph node metastasis. Lymph node metastasis was seen in 8.5% of ypT0 patients, 20% of ypT1, 18.4% of ypT2, 47.5% of ypT3, and 27.3% of ypT4. Positive lymph node metastasis was correlated with ypT stage. In addition, the difference of lymph node metastasis in ypT stage subgroups was statistically significant ( p < 0.001). Five-year disease-free survival was significantly different in the ypT stage subgroups (88.7% versus 86.7% versus 82.6% versus 64.7% versus 72.7%, p < 0.001), as was 5-year overall survival (96.2% versus 90.0% versus 95.8% versus 80.0% versus 90.9%, p < 0.001). Conclusion: YpT stage is associated with lymph node metastasis in rectal cancer treated with neoadjuvant CRT and radical operation, and ypT0 patients exhibited an 8.5% lymph node metastasis rate. Therefore, the decision for local excision or the watch-and-wait strategy for rectal cancer treated with neoadjuvant CRT and predicted to show a pathologic complete response should be considered with caution.
Playing remotely: The COVID-19 pandemic and mobile locative gaming in Northeast Brazil
Authors: Andrade Luiz Adolfo , Nery Filho Jesse 
Published: October 2022

Mobile locative games consist of a subset of mobile games that encourage players to go outside, by promoting outdoor activities and physical meetings. Because of this, their gameplay breaks the core of social distancing strategies implemented since the beginning of the COVID-19 pandemic. However, developers implemented changes in their locative games supported by the mobile game revenue model, which enabled a strategy called “playing remotely” that encourages the players to spend their money with microtransactions. This study analyses the impacts of the COVID-19 pandemic in mobile locative gaming, by examining the preferences and behavior of players from the Northeast Brazil, a region with socioeconomic inequalities and urban violence, among other issues that shape mobility practices. Accordingly, we pose a research question: how do players living in Northeast Brazil manage the mobile game revenue model for playing remotely during the COVID-19 pandemic? With this in mind, we have conducted an online survey among communities of players located in Northeast Brazil, by sharing a questionnaire with 21 questions. Seventy-four players from the region responded to our survey. The sample's age was from 16 to 58 years old, and they lived in seven of the nine states that form Northeast Brazil. We have found that players’ preference is to invest their time in gathering resources by playing the game, instead of spending their money in microtransactions for playing remotely. Moreover, we have found that mobile communication plays a significant role in keeping players in touch during the COVID-19 pandemic, allowing players to expand their networks to other cities and countries. We have concluded that playing remotely represents an important strategy to support the development of locative games and other location-based applications, which can help us to prepare for the next pandemic.
Epidemiology of Sports-Related Clavicle Fractures in the United States: Injuries From 2015 to 2019
Authors: Twomey-Kozak Jack , Whitlock Keith G. , O’Donnell Jeffrey A. , Klifto Christopher S. , Anakwenze Oke 
Published: October 2022

Background: Clavicle fractures are common orthopaedic injuries that frequently occur during sports and recreational activity. Purpose: To (1) determine the incidence rate of sports-related clavicle fractures among patients evaluated in emergency departments in the United States over a 5-year period, (2) determine the most common sports and risks associated with clavicle fractures, and (3) update the literature by comparing past and present injury trends. Study Design: Descriptive epidemiology study. Methods: The National Electronic Injury Surveillance System (NEISS) database was queried for patients evaluated with clavicle fractures in US emergency departments from 2015 to 2019. The authors evaluated the data by age, sex, race, and sport/recreational activity. Injuries were characterized based on sports-specific mechanism of injury. Using the NEISS weighted multiplier, the authors estimated annual incidence rates based on US Census data. Contingency table comparisons of categorical variables (ie, age groups vs sex distributions) were analyzed using either chi-square or Fisher exact tests as appropriate for the population size, while continuous variable comparisons were performed using 1-way analysis of variance statistical testing. Results: A total of 2386 athletic-related clavicle fractures were evaluated at participating emergency departments, translating to 304,211 clavicle fractures, with an annual per-year injury rate of 18.72 clavicle fractures per 100,000 persons at risk (95% CI, 15.28-23.67). Male athletes had disproportionately higher injury rates than female athletes ( P < .001) for every year of the study and demonstrated a higher incidence of fractures compared with female athletes (injury proportion ratio, 5.54). Patients aged 10 to 19 years accounted for the highest overall incidence of injury (64.5%). The annual incidence rate of athletic-related clavicle fractures was not significantly different during the study period ( P = .24). The most common mechanisms of injury were participation in football (26.87%), soccer (15.76%), snowboarding (5.03%), bicycling (3.77%), wrestling (3.65%), and snow skiing (3.52%). Conclusion: Study findings indicated that clavicle fractures sustained during sports and recreational activity disproportionately affect male athletes. Adolescent populations (10-19 years of age) had the highest overall incidence of injury, and the most common activities associated with clavicle fractures were football and soccer.
Locating Kashmiriyat in Ancient History: Tracing the Genealogy of Kashmir’s Syncretic Culture
Authors: Para Altaf Hussain , Rashid Haroon , Shah Sana 
Published: October 2022

The discourse on Kashmiriyat (or Kasheryut) was majorly invoked in the late twentieth-century Kashmir by diverse, often conflicting, ideological strands to legitimize their respective political positioning in the context of post-1947 political stirrings in Jammu and Kashmir. However, the discourse has remained shrouded in ambiguity owing to the multiple, disparate meanings and connotations attached to it. More commonly the term has been understood to imply a syncretic culture of Kashmir devoid of religious fundamentalism and exclusion.KL So far as the historicity of Kashmiriyat is concerned, the existing scholarly writings on the discourse have tried to locate its origins in the medieval times when the interaction and subsequent synthesis occurred between Hinduism and Islam in Kashmir; a mystic manifestation, Rishism, is often referred as the best example of this ideational formation. However, the paper attempts to argue that while the idea of Kashmiriyat as syncretic culture of Kashmir devoid of religious fundamentalism holds ground, it cannot be clearly steered away from a particular religious affiliation altogether. Secondly, this paper challenges the existing historicity and ideational trajectory of Kashmiriyat and instead attempts to trace its genealogy to Kashmir’s ancient past.
Instituting Racial Equity: The Allegheny County Racial and Ethnic Approaches to Community Health Initiative
Authors: Mendez Dara D. , Christian Stephanie N. , Casas Andrea , Scott Samantha , Hardy Hannah , Harris Roderick , Wilkerson Aja , Gary-Webb Tiffany L. 
Published: October 2022

Introduction In 2018, The Live Well Allegheny: Lifting Wellness for African Americans (LWA2) Initiative was developed to support six priority, Black communities in Allegheny County, Pennsylvania to address health equity in chronic disease. The LWA2 coalition members participated in ongoing anti-racism and racial equity sessions with a nationally recognized anti-racist facilitation team. The sessions included a 2-days experience in January 2020 along with follow up meetings throughout 2020. Methods Surveys were administered to understand their perceptions related to anti-racism and oppression and subsequent actions as a result of the sessions. Additionally, we conducted nine in-depth interviews with organizational partners (January -May 2020) to evaluate the overall effectiveness of the coalition and inform future activities. Results Ten participants completed the post session surveys. Seven out of 10 survey respondents felt they had a good understanding of how oppression (racism, sexism, capitalism) influenced their life and work. However, the majority indicated needing the tools to implement anti-racist strategies in their work. The in-depth interviews with organizational partners revealed that racial equity was of concern to all partners but there was variability in intentionality around racial equity as a core element of each organization’s mission, goals and subsequent actions. Discussion As a result of the interviews, coalition members developed a racial equity statement and theory of change for implementation in the coalition work and within individual organizations along with a plan for implementing an equity audit of the coalition. Coalitions of this kind should be intentional about implementing continuous strategies related to anti-racism for structural changes toward achieving racial equity in their overall work.
Loomisite, Ba[Be2P2O8]⋅H2O, the first natural example with the zeolite ABW-type framework, from Keystone, Pennington County, South Dakota, USA
Authors: Yang Hexiong , Gu Xiangping , Gibbs Ronald B. , Downs Robert T. 
Published: October 2022

AbstractA new beryllophosphate mineral species, loomisite (IMA2022-003), ideally Ba[Be2P2O8]⋅H2O, was found from the Big Chief mine near Keystone, Pennington County, South Dakota, USA. It occurs as divergent sprays of very thin bladed crystals with a tapered termination. Individual crystals are found up to 0.80 × 0.06 × 0.03 mm. Associated minerals include dondoellite, earlshannonite, mitridatite, rockbridgeite, jahnsite-(CaMnFe) and quartz. No twinning or parting is observed macroscopically. Loomisite is murky white in transmitted light, transparent with white streak and silky to vitreous lustre. It is brittle and has a Mohs hardness of 3½–4, with perfect cleavage on {100} and {$\bar{1}$10}. The measured and calculated densities are 3.46(5) and 3.512 g/cm3, respectively. Optically, loomisite is biaxial (+), with α = 1.579(5), β = 1.591(5), γ = 1.606(5) (white light), 2V (meas.) = 82(2)° and 2V (calc.) = 85°. It is non-pleochroic under polarised light, with a very weak (r > v) dispersion. The mineral is insoluble in water or hydrochloric acid. An electron microprobe analysis, along with the BeO content measured with an ICP-MS, yields an empirical formula (based on 9 O apfu) (Ba0.96Ca0.06)Σ1.02[(Be1.96Fe0.06)Σ2.02P1.99O8]⋅H2O, which can be simplified to (Ba,Ca)[(Be,Fe)2P2O8]⋅H2O.Loomisite is monoclinic, with space group Pn and unit-cell parameters a = 7.6292(18), b = 9.429(2), c = 4.7621(11) Å, β = 91.272(5)°, V= 342.47(14) Å3 and Z = 2. Its crystal structure is characterised by a framework of corner-sharing PO4 and BeO4 tetrahedra. The framework can be considered as built from the stacking of sheets consisting of 4- and 8-membered rings (4.82 nets) along [001] or hexagonal layers (63 nets) along [010]. The extra-framework Ba2+ and H2O are situated in the channels formed by the 8-membered rings. Topologically, loomisite represents the first natural example with the zeolite ABW-type framework, which is adopted by over 100 synthetic compounds with different chemical compositions.
Early-life and health behaviour influences on lung function in early adulthood
Authors: Mahmoud Osama , Granell Raquel , Peralta Gabriela P. , Garcia-Aymerich Judith , Jarvis Deborah , Henderson John , Sterne Jonathan 
Published: October 2022

RationaleEarly-life exposures may influence lung function at different stages of the life course. However, the relative importance of characteristics at different stages of infancy and childhood are unclear.ObjectivesTo examine the associations and relative importance of early-life events on lung function at age 24 years.MethodsWe followed 7545 children from the Avon Longitudinal Study of Parents and Children from birth to 24 years. Using previous knowledge, we classified an extensive list of putative risk factors for low lung function, covering sociodemographic, environmental, lifestyle and physiological characteristics, according to timing of exposure: 1) demographic, maternal and child; 2) perinatal; 3) postnatal; 4) early childhood; and 5) adolescence characteristics. Lung function measurements (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC and forced expiratory flow at 25–75% of FVC) were standardised for sex, age and height. The proportion of the remaining variance explained by each characteristic was calculated. The association and relative importance (RI) of each characteristic for each lung function measure was estimated using linear regression, adjusted for other characteristics in the same and previous categories.ResultsLower maternal perinatal body mass index (BMI), lower birthweight, lower lean mass and higher fat mass in childhood had the largest RI (0.5–7.7%) for decreased FVC. Having no siblings, lower birthweight, lower lean mass and higher fat mass were associated with decreased FEV1(RI 0.5–4.6%). Higher lean mass and childhood asthma were associated with decreased FEV1/FVC (RI 0.6–0.8%).ConclusionsMaternal perinatal BMI, birthweight, childhood lean and fat mass and early-onset asthma are the factors in infancy and childhood that have the greatest influence on early-adult lung function.
Velocity Constraints Based Approach for Online Trajectory Planning of High-Speed Parallel Robots
Authors: Yang Di , Xie Fugui , Liu Xinjun 
Published: October 2022

AbstractHigh-speed parallel robots have been extensively utilized in the light industry. However, the influence of the nonlinear dynamic characteristics of high-speed parallel robots on system’s dynamic response and stable operation cannot be ignored during the high-speed reciprocating motion. Thus, trajectory planning is essential for efficiency and stability from pick-and-place (PAP) actions. This paper presents a method for planning the equal-height pick-and-place trajectory considering velocity constraints to improve the PAP efficiency and stability of high-speed parallel robots. The velocity constraints in the start-and-end points can reduce vibration from picking and placing, making the trajectory more suitable to complex beltline situations. Based on velocity constraints, trajectory optimization includes trajectory smoothness and joint torque to optimize cycle time is carried out. This paper proposes an online trajectory optimization solution. By using back propagation (BP) neural networks, the solution is simplified and can be solved in real-time. Simulation and experiments were carried out on the SR4 parallel robot. The results show that the proposed method improves the efficiency, smoothness, and stability of the robot. This paper proposes an online trajectory planning method which is velocity constraints based and can improve the efficiency and stability of high-speed parallel robots. The work of this research is conducive to finely applying high-speed parallel robots.
A chromosome-level genome of Semiothisa cinerearia provides insights into its genome evolution and control
Authors: Chi Shengqi , Wang Yanchun , Wang Zhongkai , Li Haorong , Gu Songdong , Ren Yandong 
Published: October 2022

Abstract
Background
Semiothisa cinerearia belongs to Geometridae, which is one of the most species-rich families of lepidopteran insects. It is also one of the most economically significant pests of the Chinese scholar tree (Sophora japonica L.), which is an important urban greenbelt trees in China due to its high ornamental value. A genome assembly of S. cinerearia would facilitate study of the control and evolution of this species.

Results
We present a reference genome for S. cinerearia; the size of the genome was ~ 580.89 Mb, and it contained 31 chromosomes. Approximately 43.52% of the sequences in the genome were repeat sequences, and 21,377 protein-coding genes were predicted. Some important gene families involved in the detoxification of pesticides (P450) have expanded in S. cinerearia. Cytochrome P450 gene family members play key roles in mediating relationships between plants and insects, and they are important in plant secondary metabolite detoxification and host-plant selection. Using comparative analysis methods, we find positively selected gene, Sox15 and TipE, which may play important roles during the larval-pupal metamorphosis development of S. cinerearia.

Conclusion
This assembly provides a new genomic resource that will aid future comparative genomic studies of Geometridae species and facilitate future evolutionary studies on the S. cinerearia.
Whole genome sequencing of Moraxella bovis strains from North America reveals two genotypes with different genetic determinants
Authors: Wynn Emily L. , Hille Matthew M. , Loy John Dustin , Schuller Gennie , Kuhn Kristen L. , Dickey Aaron M. , Bono James L. , Clawson Michael L. 
Published: October 2022

Abstract
Background
Moraxella bovis and Moraxella bovoculi both associate with infectious bovine keratoconjunctivitis (IBK), an economically significant and painful ocular disease that affects cattle worldwide. There are two genotypes of M. bovoculi (genotypes 1 and 2) that differ in their gene content and potential virulence factors, although neither have been experimentally shown to cause IBK. M. bovis is a causative IBK agent, however, not all strains carry a complete assortment of known virulence factors. The goals of this study were to determine the population structure and depth of M. bovis genomic diversity, and to compare core and accessory genes and predicted outer membrane protein profiles both within and between M. bovis and M. bovoculi.

Results
Phylogenetic trees and bioinformatic analyses of 36 M. bovis chromosomes sequenced in this study and additional available chromosomes of M. bovis and both genotype 1 and 2 M. bovoculi, showed there are two genotypes (1 and 2) of M. bovis. The two M. bovis genotypes share a core of 2015 genes, with 121 and 186 genes specific to genotype 1 and 2, respectively. The two genotypes differ by their chromosome size and prophage content, encoded protein variants of the virulence factor hemolysin, and by their affiliation with different plasmids. Eight plasmid types were identified in this study, with types 1 and 6 observed in 88 and 56% of genotype 2 strains, respectively, and absent from genotype 1 strains. Only type 1 plasmids contained one or two gene copies encoding filamentous haemagglutinin-like proteins potentially involved with adhesion. A core of 1403 genes was shared between the genotype 1 and 2 strains of both M. bovis and M. bovoculi, which encoded a total of nine predicted outer membrane proteins.

Conclusions
There are two genotypes of M. bovis that differ in both chromosome content and plasmid profiles and thus may not equally associate with IBK. Immunological reagents specifically targeting select genotypes of M. bovis, or all genotypes of M. bovis and M. bovoculi together could be designed from the outer membrane proteins identified in this study.