bluuebunny/crossref_metadata_2025_split huggingface dataset:
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer
Authors: Doffo Josefina , Bamopoulos Stefanos A. , Köse Hazal , Orben Felix , Zang Chuanbing , Pons Miriam , den Dekker Alexander T. , Brouwer Rutger W. W. , Baluapuri Apoorva , Habringer Stefan , Reichert Maximillian , Illendula Anuradha , Krämer Oliver H. , Schick Markus , Wolf Elmar , van IJcken Wilfred F. J. , Esposito Irene , Keller Ulrich , Schneider Günter , Wirth Matthias 
Published: February 2022

Significance
Recent evidence demonstrated the existence of molecular subtypes in pancreatic ductal adenocarcinoma (PDAC), which resist all current therapies. The paucity of therapeutic options, including a complete lack of targeted therapies, underscores the urgent and unmet medical need for the identification of targets and novel treatment strategies for PDAC. Our study unravels a function of the transcription factor RUNX1 in apoptosis regulation in PDAC. We show that pharmacological RUNX1 inhibition in PDAC is feasible and leads to NOXA-dependent apoptosis. The development of targeted therapies that influence the transcriptional landscape of PDAC might have great benefits for patients who are resistant to conventional therapies. RUNX1 inhibition as a new therapeutic intervention offers an attractive strategy for future therapies.
Intranuclear HSV-1 DNA ejection induces major mechanical transformations suggesting mechanoprotection of nucleus integrity
Authors: Evilevitch Alex , Hohlbauch Sophia V. 
Published: February 2022

Significance
We discovered major mechanical transformations in both chromatin and nuclear lamina at the initial stage of herpesvirus replication. We found that chromatin stiffness is dramatically increased, while nuclear laminar rigidity is decreased, immediately after viruses eject their genomes into a host cell nucleus. A stiffness increase in chromatin mechanics suggests a viral DNA–induced chromatin compaction, helping to maintain nuclear morphology. The observed softening of the nuclear lamina, on the other hand, provides mechanoprotection of the nuclear envelope since lamina act as an internal shock absorber for mechanical deformations. These transitions lead to a robust mechanical response aimed at maintaining nuclear integrity; this mechanism could facilitate viral genome replication. This is an observation of mechanoadaptation in cells utilized by herpesviruses.
Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor
Authors: Goyette Jesse , Depoil David , Yang Zhengmin , Isaacson Samuel A. , Allard Jun , van der Merwe P. Anton , Gaus Katharina , Dustin Michael L. , Dushek Omer 
Published: February 2022

Significance
Src homology 2 (SH2) domains are phosphotyrosine binding motifs that play key roles in cellular signaling. There are 110 proteins in the human genome containing SH2 binding domains, of which 10 contain tandem SH2 domains. Tandem domains have been shown to improve avidity and specificity and contribute to allostery. Here, we show that tandem SH2 domains can also exhibit binding lifetimes that are accelerated by the activity of phosphatases. This accelerated unbinding requires tandem SH2 domains to engage their substrates in dynamic binding modes that cycle between single SH2-bound states. We experimentally confirm that this is the case for the well-studied kinase ZAP70 binding the T cell receptor. We suggest that accelerated unbinding is a general feature of signaling networks.
In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective
Authors: Kim Jinkyung , Ricci Anthony J. 
Published: February 2022

Aminoglycosides (AGs) are commonly used antibiotics that cause deafness through the irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then target HCs remains unresolved. Here, we performed time-lapse multicellular imaging of cochlea in live adult hearing mice via a chemo-mechanical cochleostomy. The in vivo tracking revealed that systemically administered Texas Red–labeled gentamicin (GTTR) enters the cochlea via the stria vascularis and then HCs selectively. GTTR uptake into HCs was completely abolished in transmembrane channel-like protein 1 (TMC1) knockout mice, indicating mechanotransducer channel-dependent AG uptake. Blockage of megalin, the candidate AG transporter in the stria vascularis, by binding competitor cilastatin prevented GTTR accumulation in HCs. Furthermore, cilastatin treatment markedly reduced AG-induced HC degeneration and hearing loss in vivo. Together, our in vivo real-time tracking of megalin-dependent AG transport across the blood–labyrinth barrier identifies new therapeutic targets for preventing AG-induced ototoxicity.
In search of subjective meaning in Swedish pseudocoordination
Authors: Blensenius Kristian , Lilja Peter Andersson 
Published: February 2022

Abstract
This study provides a discussion of the development of subjective meaning associated with the motion-verb pseudocoordination gå och V ‘go/walk and V’ and the posture-verb pseudocoordination sitta och V ‘sit and V’, using historical and present-day linguistic data. It is claimed that an interpretation in terms of item-based analogy and entrenchment of frequent meaning clusters is the most plausible analysis for the development of subjective (and pejorative) meaning associated with gå och V. The study of sitta och V is preliminary, but the results indicate that the subjective meaning of this construction is less entrenched that that of the gå och V construction and that the subjective overtone of subjectivity may be a result of the combination of the social/cultural meaning of the posture and certain intrinsically pejorative verbs, together with certain locatives.
Partial versus full agreement in Turkish possessive and clausal DP-Coordination
Authors: Tat Deniz , Kornfilt Jaklin 
Published: February 2022

Abstract
In Turkish nominal phrases and clauses where a coordinated possessor or subject is related to agreement morphology on the possessee or the nominalized predicate, respectively, agreement is realized either in full or in partial expression. The choice between the two is determined in certain cases by syntactic phenomena, suggesting that agreement must figure in syntax. However, partial possessor agreement appears to result from a relationship between the possessee or nominalized predicate, and the last conjunct only, hinting that it is also subject to linear locality conditions. We conclude that the agreement phenomenon in languages results from conditions that apply in syntax proper and from conditions that apply in a post-syntactic component separately, which can alter the output of syntax proper where applicable.
Syntax, semantics, and pragmatics of Pseudo-Coordination
Authors: Mitrović Moreno 
Published: February 2022

Abstract
There have been very few attempts to date to provide an explicit semantics/pragmatics for Pseudo-Coordination (PseCo) expressions. This chapter is an attempt to fill that gap, zooming in on the ‘go-(and-)get’-type. To do so, I first provide a syntactic account of PseCo, which derives from a standard coordination structure (which I label Junction), onto and from which a compositional semantic account is derived. The signature pragmatic properties of PseCo of negative-emotive factivity are also derived. Aside from providing the first systematic and cross-modular analysis of PseCo, the chapter also provides a number of new diagnostics for identifying and classifying PseCo expressions which may be useful in future work on the topic.
Sentence-final particles in Mandarin Chinese
Authors: Paul Waltraud , Yan Shanshan 
Published: February 2022

Abstract
Sentence-final particles (SFPs) in Mandarin Chinese realize the heads of three projections in the rigidly
ordered head-final CP ‘Low CP < ForceP < AttitudeP’. Only the highest projection AttitudeP encodes
discourse-related properties, whereas ForceP encodes the sentence-type (interrogative, imperative). Low Cs interact
with properties of the TP-internal extended verbal projection and are obligatory when acting as (non-default) anchors.
They play an important role in determining the temporal interpretation and finiteness in Mandarin Chinese and can
therefore no longer be neglected by studies addressing these issues. There is no evidence for an “incremental”
acquisition “up the tree” of the different projections in the split CP nor for the acquisition of TP prior to CP, as
postulated by the cartographic approach.
What’s extravagant about be-sandal-ed feet?
Authors: Kempf Luise , Hartmann Stefan 
Published: February 2022

Abstract
Extravagance can be conceived of as a (more or less) deliberate deviation from established norms that evokes surprise or attention. In this paper, we present an empirical case study of a rare but quite remarkable morphological pattern, namely German pseudo-participles – forms that look like past participles but lack a verbal counterpart, e.g., be-brill-t ‘be-glassed’ (derived from the noun Brille ‘glasses’).
In our study, we investigate the extravagance of the pattern using data from the webcorpus DECOW16A. We combine a detailed qualitative analysis of singleton coinages with various explorative quantitative approaches, taking into account the complexity of the formations and their anchoring in the context. In addition, we examine metalinguistic indicators of extravagance such as double quotes and meta-comments. We argue that German pseudo-participles are a prime example of an “extravagant” phenomenon at the interface of morphology and pragmatics, and as such can be instructive for our understanding of extravagant morphology on a general level, especially with regard to the role of surprise in generating extravagant effects.
do not repeat
Authors: Kentner Gerrit 
Published: February 2022

Abstract
This chapter offers a synopsis of repetitive and reduplicative constructions in German, a set of diverse morphophonological types mostly found in substandard registers of the language. A phonological examination of these structures suggests that German strictly prohibits exact adjacent repetition of phonological material within lexical representations. I suggest this generalisation to be a grammatical requirement in the lexicon that holds across all levels of the phonological hierarchy, with only a few well-defined exceptions (abbreviations, loans, onomatopoeias, and ideophones). Reduplicative constructions are situated between the poles of marginal, sub-standard language use, apparent deviance from the concatenative ideal that otherwise pervades German morphology, and strict adherence to the lexical-phonological requirement regarding identity avoidance. In this respect, they are, as I argue, characteristic instances of extravagant morphology.
Ytterbium doped ZnO nanolaminated planar waveguide for ring resonator applications
Authors: Agarwal Lucky , Sambasiva Rao K , Srivastava Anshika , Tripathi Shweta 
Published: February 2022

AbstractIn the present paper, optical and structural properties of Yb doped ZnO (YZO) are studied for different Yb molar concentrations. The YZO thin films are deposited over the silicon substrate via the sol-gel spin coating method. The range of Yb doping content (concentration) is 0 mol% to 1.5 mol% in ZnO. The morphological variations of the deposited thin film are studied using XRD, FE-SEM, atomic force microscopy, and Ellipsometer. The obtained results indicate that the YZO thin film possesses a single crystalline structure with (1 0 0) as the preferential orientation. All samples have a smooth, dense structure and are free of pinholes. A detailed optical result showed a favorable behavior of YZO thin film for integrated photonic devices. Hence, an optical ring resonator is simulated using MODE and FDTD tool of Lumerical to validate the experimental results. The eigen mode solver is incorporated in MODE (wavelength ranging from 300 to 800 nm) to compute refractive index, propagation constant, group velocity, losses, dispersion and transmission intensity. Furthermore, quality factor, free spectral range and fullwidth at half-maximum of the ring resonator are evaluated using FDTD.
Particle trapping, size-filtering, and focusing in the nonthermal plasma synthesis of sub-10 nanometer particles
Authors: Xiong Zichang , Lanham Steven , Husmann Eric , Nelson Gunnar , Eslamisaray Mohammad Ali , Polito Jordyn , Liu Yaling , Goree John , Thimsen Elijah , Kushner Mark J , Kortshagen Uwe R 
Published: February 2022

Abstract
Low-pressure nonthermal flowing plasmas are widely used for the gas-phase synthesis of nanoparticles and quantum dots of materials that are difficult or impractical to synthesize using other techniques. To date, the impact of temporary electrostatic particle trapping in these plasmas has not been recognized, a process that may be leveraged to control particle properties. Here, we present experimental and computational evidence that, during their growth in the plasma, sub-10 nm silicon particles become temporarily confined in an electrostatic trap in radio-frequency excited plasmas until they grow to a size at which the increasing drag force imparted by the flowing gas entrains the particles, carrying them out of the trap. We demonstrate that this trapping enables the size filtering of the synthesized particles, leading to highly monodisperse particle sizes, as well as the electrostatic focusing of the particles onto the reactor centerline. Understanding of the mechanisms and utilization of such particle trapping will enable the design of plasma processes with improved size control and the ability to grow heterostructured nanoparticles.
Fault diagnosis of rolling bearing under time-varying speed conditions based on EfficientNetv2
Authors: Qu Haoyang , Yang Jianhua , Shen Mengen , Chen Huatao , Zhou Dengji 
Published: February 2022

Abstract
The rolling bearing is a widely-used component in engineering. The fault diagnosis of rolling bearings is key to ensuring the normal operation of equipment. At present, research into the fault diagnosis of rolling bearings mainly focuses on the analysis of vibration data under constant working conditions. However, when dealing with practical engineering problems, equipment frequently operates at variable speed. To analyse the vibration data in the case of frequency conversion and accurately extract the fault characteristic frequency is a challenge, especially when the fault characteristics are weak. In addition, traditional vibration characteristic analysis requires professional technicians to supervise the operation of the equipment, which requires a certain professional ability of the staff. Based on the above two problems, this paper proposes a rolling bearing fault diagnosis model under time-varying speed working conditions, based on the EfficientNetv2 network. This method uses a short-time Fourier transform to convert a one-dimensional vibration signal into a two-dimensional image signal, and uses the advantages of an image recognition network to realize the fault diagnosis under time-varying speed conditions. After training the network, based on transfer learning, the experimental data verify that the accuracy of the results reaches 99.9 ± 0.1%, even in the case of weak fault characteristics, and there is no need for professional technicians to supervise and diagnose once the model is trained, which is conducive to practical application.
Thermoelectric stability of dual-wall and conventional type K and N thermocouples
Authors: Tucker D J L , Edler F , Žužek V , Bojkovski J , Garcia-Izquierdo C , Parrondo M , Šindelářová L , Arifovic N 
Published: February 2022

Abstract
Mineral insulated metal sheathed (MIMS) base metal thermocouples experience thermoelectric drift over their lifetime caused by use at high temperatures and metallurgical changes, causing spurious measurement errors. CCPI Europe Limited and University of Cambridge have designed a MIMS thermocouple with an additional inner sheath, in order to protect the thermoelements from the effects that cause thermoelectric drift. The performance of these dual-wall thermocouples and conventional type N and type K thermocouples are assessed at six different National Metrology Institutes (NMIs) using two different testing regimes: isothermal testing at 1200 °C, and thermal cycling tests between 300 °C and 1150 °C. The investigation demonstrates that in both testing regimes, the type N dual-wall thermocouples showed a significantly reduced thermoelectric drift by about a factor of three compared to the conventional thermocouples. There was no significant difference between the type K dual-wall and conventional type K thermocouples in the isothermal tests, and the type K dual-wall thermocouples showed greater drift than the conventional thermocouples in the thermal cycling tests, but the conventional type K thermocouples were less robust than the dual-wall type K thermocouples. The results presented in this paper represent an impartial assessment of the thermoelectric stability of both dual-wall thermocouples and conventional thermocouples, which may provide assurance to potential users.
Teacher interventions and student strategies for circular motion problems: a matrix representation
Authors: Pendrill Ann-Marie 
Published: February 2022

Abstract
Students’ understanding of forces in circular motion is often incomplete. The problems are not limited to confusions about centripetal acceleration and centrifugal forces. This paper considers possible effects of different interventions by a teacher who has discovered the many types of free-body diagrams drawn by students for circular motion in a vertical plane. Students’ free-body diagrams often show a lack of attention to lengths of force arrows and to the direction and size of the sum of forces. The strategies used by students may differ depending on the situation and questioning by the teacher can remind students of critical aspects they have overlooked. The revisions of responses following interventions reveal information that is not available from just a single response. This paper discusses how a matrix can be used to express the probability for revisions of responses for different teacher interventions and also help teachers decide on future interventions.
Unified treatment for photoluminescence and scattering of coupled metallic nanostructures: I. Two-body system
Authors: Cheng Yuqing , Sun Mengtao 
Published: February 2022

Abstract
Photoluminescence (PL) and scattering phenomena from metallic nanostructures have been explained and understood by several point of views. One of them is based on the classic harmonic oscillator model, which describes PL of single mode. In this study, we continue to expand this classic model to a coupling case, which involves two oscillators that interact with each other together with the excitation electric field. The new generated modes due to the coupling are carefully analyzed, including their behaviors varying with the coupling coefficients in different cases. Furthermore, for practical purpose, PL spectra and white light scattering spectra of two individual metallic nanostructures are calculated as examples employing the model to verify its validity. This work would give a deeper understanding on coupling PL and scattering phenomena and is helpful to relative applications.
Linear seesaw model with T
7 symmetry for neutrino mass and mixing
Authors: Vien V. V. 
Published: February 2022

Abstract
We propose a low-scale Standard Model extension with

symmetry that can successfully explain observed neutrino oscillation results within the

range. Small neutrino masses are obtained via the linear seesaw mechanism. Normal and inverted neutrino mass orderings are considered with three lepton mixing angles in their experimentally allowed

ranges. The model provides a suitable correlation between the solar and reactor neutrino mixing angles, which is consistent with the

pattern. The prediction for the Dirac phase is

for both normal and inverted orderings, including its experimentally maximum value, while those for the two Majorana phases are

for normal ordering and

for inverted ordering. In addition, the predictions for the effective neutrino masses are consistent with the present experimental bounds.
Detecting and Monitoring Tidal Dissipation of Hot Jupiters in the Era of SiTian
Authors: Yang Fan , Wang Wei , Wei Xing , Zhang Hui , Zhou Ji-Lin , Shan Su-Su , Zheng Jie , Zong Wei-Kai , Yang Ming , Bai Yu , Wang Song , Zheng Jia-Chen , Xu Yu-Ru , Li Yu-Feng , Lu You-Jun , Liu Ji-Feng 
Published: February 2022

Abstract
Transit Timing Variation (TTV) of hot Jupiters provides direct observational evidence of planet tidal dissipation. Detecting tidal dissipation through TTV needs high precision transit timings and long timing baselines. In this work, we predict and discuss the potential scientific contribution of the SiTian Survey in detecting and analyzing exoplanet TTV. We develop a tidal dissipation detection pipeline for the SiTian Survey that aims at time-domain astronomy with 72 1 m optical telescopes. The pipeline includes the modules of light curve deblending, transit timing acquisition and TTV modeling. SiTian is capable of detecting more than 25,000 exoplanets among which we expect ∼50 sources to show evidence of tidal dissipation. We present detection and analysis of tidal dissipating targets, based on simulated SiTian light curves of XO-3b and WASP-161b. The transit light curve modeling gives consistent results within 1σ to input values of simulated light curves. Also, the parameter uncertainties predicted by Markov Chain Monte Carlo are consistent with the distribution obtained from simulating and modeling the light curve 1000 times. The timing precision of SiTian observations is ∼0.5 minutes with one transit visit. We show that differences between TTV origins, e.g., tidal dissipation, apsidal precession and multiple planets, would be significant, considering the timing precision and baseline. The detection rate of tidal dissipating hot Jupiters would answer a crucial question of whether the planet migrates at an early formation stage or random stages due to perturbations, e.g., planet scattering or secular interaction. SiTian identified targets would be constructive given that the sample would extend tenfold.
Division of Risky Sections of Railway External Environment Based on TOPSIS
Authors: Pan Zibiao 
Published: February 2022

Abstract
With the rapid development of economy and society, the external environmental problems of railways have become more and more prominent, and external environmental accidents have occurred from time to time. The external environmental problems along the railway have become more and more prominent, which has become one of the important risks that endanger railway safety and affect the order of trains. By analyzing the external environmental risk profile, quantifying the impact of different types of hidden danger points along the line, dividing the hidden danger section of the line, dividing the risk section, and carrying out special rectification of the sections with different risk levels, it will be conducive to efficient and centralized rectification of the external environment and improve environmental governance Efficiency and risk control level.