bluuebunny/crossref_metadata_2025_split huggingface dataset:
Living Leukocyte‐Based Drug Delivery Systems
Authors: Chen Yaxin , Qin Duotian , Zou Jianhua , Li Xiaobin , Guo Xin Dong , Tang Yi , Liu Chuang , Chen Wei , Kong Na , Zhang Can Yang , Tao Wei 
Published: November 2022

AbstractLeukocytes play a vital role in immune responses, including defending against invasive pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the immune system is activated in vivo, leukocytes accomplish a series of orderly and complex regulatory processes. While cancer and inflammation‐related diseases like sepsis are critical medical difficulties plaguing humankind around the world, leukocytes have been shown to largely gather at the focal site, and significantly contribute to inflammation and cancer progression. Therefore, the living leukocyte‐based drug delivery systems have attracted considerable attention in recent years due to the innate and specific targeting effect, low immunogenicity, improved therapeutic efficacy, and low reverse effect. In this review, the recent advances in the development of living leukocyte‐based drug delivery systems including macrophages, neutrophils, and lymphocytes as promising treatment strategies for cancer and inflammation‐related diseases are introduced. The advantages, current challenges, and limitations of these delivery systems are also discussed, as well as perspectives on the future development of precision and targeted therapy in the clinics are provided. Collectively, it is expected that such kind of living cell‐based drug delivery system is promising to improve or even revolutionize the treatments of cancers and inflammation‐related diseases in the clinics.
Stationary states of hydrogen‐producing reactions in nonequilibrium plasma
Authors: Chen Xiaoshuang , Thimsen Elijah 
Published: October 2022

AbstractIn this work, stationary states of hydrogen‐producing reactions in nonequilibrium plasmas are explored, namely the water splitting and water gas shift reactions. For both reactions, the effluent from the reactor at long residence times in the plasma was found to be independent of the influent speciation. In other words, feeding the reactor either 0.1H2O or 0.1H2 + 0.05O2 by mole produced the same effluent composition, and similarly, feeding the reactor 0.1CO + 0.1H2O produced nominally the same effluent as 0.1CO2 + 0.1H2. For both reactions, the effluent from the plasma was found to be very far from local equilibrium at the total pressure and background temperature of the plasma and shifted in the endothermic direction relative to the local equilibrium speciation. This work further demonstrates that special attention must be paid to the recombination zone in plasmachemical processes. The recombination zone tends to drive the gas composition from plasma stationary states back towards local equilibrium.
A phase 1b study of venetoclax and azacitidine combination in patients with relapsed or refractory myelodysplastic syndromes
Authors: Zeidan Amer M. , Borate Uma , Pollyea Daniel A. , Brunner Andrew M. , Roncolato Fernando , Garcia Jacqueline S. , Filshie Robin , Odenike Olatoyosi , Watson Anne Marie , Krishnadasan Ravitharan , Bajel Ashish , Naqvi Kiran , Zha Jiuhong , Cheng Wei‐Han , Zhou Ying , Hoffman David , Harb Jason G. , Potluri Jalaja , Garcia‐Manero Guillermo 
Published: October 2022

AbstractPatients with relapsed/refractory (R/R) higher‐risk myelodysplastic syndromes (MDS) have a dismal median overall survival (OS) after failing hypomethylating agent (HMA) treatment. There is no standard of care for patients after HMA therapy failure; hence, there is a critical need for effective therapeutic strategies. Herein, we present the safety and efficacy of venetoclax + azacitidine in patients with R/R MDS. This phase 1b, open‐label, multicenter study enrolled patients ≥18 years. Patients were treated with escalating doses of oral venetoclax: 100, 200, or 400 mg daily for 14 days every 28‐day cycle. Azacitidine was administered on Days 1–7 every cycle at 75 mg/m2/day intravenously/subcutaneously. Responses were assessed per modified 2006 International Working Group (IWG) criteria. Forty‐four patients (male 86%, median age 74 years) received venetoclax + azacitidine treatment. Median follow‐up was 21.2 months. Hematological adverse events of Grade ≥ 3 included febrile neutropenia (34%), thrombocytopenia (32%), neutropenia (27%), and anemia (18%). Pneumonia (23%) was the most common Grade ≥ 3 infection. Marrow responses were seen including complete remission (CR, n = 3, 7%) and marrow CR (mCR, n = 14, 32%); 36% (16/44) achieved transfusion independence (TI) for RBCs and/or platelets, and 43% (6/14) with mCR achieved hematological improvement (HI). The median time to CR/mCR was 1.2 months, and the median duration of response for CR + mCR was 8.6 months. Median OS was 12.6 months. Venetoclax + azacitidine shows activity in patients with R/R MDS following prior HMA therapy failure and provides clinically meaningful benefits, including HI and TI, and encouraging OS.
Proposed risk‐scoring model for estimating the prognostic impact of 1q gain in patients with newly diagnosed multiple myeloma
Authors: Yang Peiyu , Chen Haimin , Liang Xinyue , Xu Weiling , Yu Shanshan , Huang Wenyang , Yi Xingcheng , Guo Qiang , Tian Mengru , Yue Tingting , Li Mengyao , Zhang Yingjie , Zhang Mengxue , Yan Yurong , Hu Zhongli , Kumar Shaji K. , Zhou Fan , Dai Yun , Jin Fengyan 
Published: October 2022

Abstract1q gain (+1q) is the most common high‐risk cytogenetic abnormality (HRCA) in patients with multiple myeloma (MM). However, its prognostic value remains unclear in the era of novel agents. Here, we retrospectively analyzed the impact of +1q on the outcomes of 934 patients newly diagnosed with MM. +1q was identified in 53.1% of patients and verified as an independent variate for inferior overall survival (OS) (hazard ratio, 1.400; 95% confidence interval, 1.097–1.787; p = .007). Concurrence of other HRCAs (particularly t(14;16) and del(17p)) further exacerbated the outcomes of patients with +1q, suggesting prognostic heterogeneity. Thus, a risk‐scoring algorithm based on four risk variates (t(14;16), hypercalcemia, ISS III, and high LDH) was developed to estimate the outcomes of patients with +1q. Of the patients, 376 evaluable patients with +1q were re‐stratified into low (31.6%), intermediate (61.7%), and high risk (6.7%) groups, with significantly different progression‐free survival and OS (p < .0001), in association with early relapse of the disease. The prognostic value of this model was validated in the CoMMpass cohort. While attaining undetectable MRD largely circumvented the adverse impact of +1q, it scarcely ameliorated the outcome of the patients with high risk, who likely represent a subset of patients with extremely poor survival. Hence, patients with +1q are a heterogeneous group of high‐risk patients, therefore underlining the necessity for their re‐stratification. The proposed simple risk‐scoring model can estimate the outcomes of patients with +1q, which may help guide risk‐adapted treatment for such patients.
Phase 1/2 study of epacadostat in combination with durvalumab in patients with metastatic solid tumors
Authors: Naing Aung , Algazi Alain P. , Falchook Gerald S. , Creelan Benjamin C. , Powderly John , Rosen Seth , Barve Minal , Mettu Niharika B. , Triozzi Pierre L. , Hamm John , Zhou Gongfu , Walker Chris , Dong Zhiwan , Patel Manish R. 
Published: October 2022

AbstractBACKGROUNDTargeting programmed cell death protein 1 (PD‐1) and indoleamine 2,3‐dioxygenase (IDO1) pathways is an appealing option for cancer treatment.METHODSThe open‐label, phase 1/2 ECHO‐203 study evaluated the safety, tolerability, and efficacy of the IDO1 inhibitor epacadostat in combination with durvalumab, a human anti–PD‐L1 monoclonal antibody in adult patients with advanced solid tumors.RESULTSThe most common treatment‐related adverse events were fatigue (30.7%), nausea (21.0%), decreased appetite (13.1%), pruritus (12.5%), maculopapular rash (10.8%), and diarrhea (10.2%). Objective response rate (ORR) in the overall phase 2 population was 12.0%. Higher ORR was observed in immune checkpoint inhibitor (CPI)‐naïve patients (16.1%) compared with patients who had received previous CPI (4.1%). Epacadostat pharmacodynamics were evaluated by comparing baseline kynurenine levels with those on therapy at various time points. Only the 300‐mg epacadostat dose showed evidence of kynurenine modulation, albeit unsustained.CONCLUSIONSEpacadostat plus durvalumab was generally well tolerated in patients with advanced solid tumors. ORR was low, and evaluation of kynurenine concentration from baseline to cycle 2, day 1, and cycle 5, day 1, suggested >300 mg epacadostat twice daily is needed to ensure sufficient drug effect.Clinical trial informationA study of epacadostat (INCB024360) in combination with durvalumab (MEDI4736) in subjects with selected advanced solid tumors (ECHO‐203) (NCT02318277).
Opposing effects of income inequality on health: The role of perceived competitiveness and avoidance/approach motivation
Authors: Sommet Nicolas , Elliot Andrew J. 
Published: October 2022

AbstractIncome inequality is commonly posited to elevate concerns about social status that undermine psychological health, but the empirical evidence is inconsistent. Here we propose that these inconsistencies conceal opposing processes: Income inequality prompts perceived competitiveness, which can both negatively predict psychological health via avoidance motivation and positively predict psychological health via approach motivation. First, we conducted a two‐year longitudinal study (1,700+ participants from 500+ county identifiers) and provided support for our opposing processes model. Second, we conducted three pre‐preregistered studies using an experimental‐causal‐chain design. We sequentially showed that induced income inequality increased perceived competitiveness (Study 2a; 444 participants), induced perceived competitiveness increased avoidance and approach motivation (Study 2b; 1,018 participants), and induced avoidance/approach motivation decreased/increased psychological health (Study 2c; 562 participants). These findings suggest that scholars should shift from studying the main effects of income inequality on psychological health to studying the psychological processes involved in the inequality‐health relation.
A longitudinal examination of the factors that facilitate and hinder support for conservative and progressive social movements
Authors: González Roberto , Chayinska María , Plaza Alejandro , Bargsted Matías , Miranda Daniel 
Published: October 2022

AbstractThis paper examines social‐psychological factors that can facilitate and hinder public support for conservative agendas over time. Using four waves of longitudinal panel data from Chile (N = 2,394), we estimated the between‐person and within‐person associations among individuals’ self‐reported conservative ideologies, political disaffection, civic behaviour, political attitudes towards democracy and social change, and their support for conservative (vs progressive) social movements over time. As expected, between‐person increases in social dominance orientation (SDO), right‐wing authoritarianism (RWA), right‐wing self‐categorization, and political disaffection correlated positively with support for conservative social movements. Between‐person increases in people's social change beliefs, support for democracy, and civic participation predicted less support for conservative social movements over time. Within‐person increases in RWA and SDO correlated positively with conservative social movement support, whereas civic participation correlated negatively with it. Results provide novel evidence for the dynamic processes underlying support for conservative/progressive agendas.
Humanness in times of uncertainty: On the link between perceived job insecurity, self‐objectification and well‐being
Authors: Baldissarri Cristina , Pagliaro Stefano , Teresi Manuel , Andrighetto Luca 
Published: October 2022

AbstractThe current work scenario is pervaded by widespread perceptions of job insecurity, which is one of the main stress factors for workers and their well‐being. This article aims to investigate the link between these perceptions and a most inner dimension, that is, people's tendency to self‐objectify (i.e., self‐viewing as objects rather than fully human beings). Furthermore, we aim to verify the role of this self‐objectifying process in explaining the well‐established relation between perceived job insecurity and well‐being. Across four studies and a single‐article meta‐analysis (total N = 684), we show that perceived job insecurity is consistently linked with self‐objectification. Furthermore, this objectifying self‐perception is associated with decreased well‐being and plays a mediational role in the link between perceived job insecurity and this latter variable.
Intergroup threat, knowledge of the outgroup, and willingness to purchase ingroup and outgroup products: The mediating role of intergroup emotions
Authors: Long Feiteng , Ye Zi , Liu Guohua 
Published: October 2022

AbstractEstablished theories have acknowledged that intergroup threat is one of the key determinants of intergroup attitudes and behaviours, but how intergroup threat can affect consumer behaviour remains unclear. Here, four preregistered studies (total N = 988) examined the effect of intergroup threat (manipulated in terms of realistic and symbolic threats) on consumers’ willingness to purchase ingroup and outgroup products. In the context of China–West relations, we measured Chinese consumers’ willingness to purchase Chinese (ingroup) and Western (outgroup) products. These studies together revealed that realistic and symbolic threats (versus control) increased willingness to purchase ingroup products and decreased willingness to purchase outgroup products, regardless of the product category. Studies 3a and 3b also measured knowledge of the outgroup as a potential moderator, revealing that realistic threat (versus control) reduced willingness to purchase outgroup products only among individuals who had less knowledge of the outgroup. Furthermore, Study 3b showed that the intergroup threat manipulation indirectly influenced consumers’ willingness to purchase ingroup/outgroup products through increased anger and decreased hope. We discussed the contributions to the intergroup relations and consumer behaviour literature and the implications for transnational marketing practices, as well as the limitations of this research.
Veg*ns’ and omnivores’ reciprocal attitudes and dehumanization: The role of social dominance orientation, ingroup identification, and anticipated reproach
Authors: Guidetti Margherita , Graziani Anna Rita , Cavazza Nicoletta 
Published: October 2022

AbstractTwo studies compared omnivores’ and veg*ns’ attitudes and dehumanization tendencies toward each other and identified the social psychological factors explaining them. Study 1 (N = 208, Italians) showed that veg*ns’ hold less positive attitudes toward omnivores than the reverse, and attributed to them less human uniqueness and nature; these differences were explained by veg*ns’ stronger identification with the ingroup and higher perceptions of reproach from the outgroup, even if omnivores’ higher levels of social dominance orientation worsened their attitude toward veg*ns. Study 2 (preregistered,N = 200, mostly from UK) overall replicated Study 1 findings at the explicit level. Interestingly, omnivores’ and veg*ns’ implicit attitudes were equally positive (but less positive than self‐reported attitudes) and not predicted by the same mediators associated with the explicit measures. This work suggests that neither veg*ns nor omnivores hold negative attitudes toward each other: they were both positive or neutral toward the outgroup, even if at the explicit level this positivity is greater for omnivores.
Solidarity across group lines: Secondary transfer effect of intergroup contact, perceived moral distance, and collective action
Authors: Vezzali Loris , Pagliaro Stefano , Di Bernardo Gian Antonio , McKeown Shelley , Margherita Cocco Veronica 
Published: October 2022

AbstractWe tested, in three studies, whether the generalization of contact effects from primary to secondary outgroups—the secondary transfer effect (STE)—occurs for collective action. The results supported a serial mediation model: contact with immigrants by advantaged group members (Italians: Study 1, N = 146, 121 females, Mage = 28.31 years; Study 3, N = 406, 239 females, Mage = 36.35; British people, Study 2, N = 160, 113 females, Mage = 32.31) was associated with lower perceived moral distance toward primary outgroups, which in turn was associated with more positive attitudes and greater collective action intentions toward primary outgroups, and lower perceived moral distance toward secondary outgroups. Lower perceived moral distance toward secondary outgroups and stronger collective action intentions toward the primary outgroup were associated with higher collective action intentions toward secondary outgroups (results were inconsistent for attitudes). We discuss the findings with a focus on how a consideration of perceived moral distance extends current theorizing, and the relevance of generalized prejudice for the STE.
Curcumin‐loaded cockle shell‐derived calcium carbonate nanoparticles ameliorates lead‐induced neurotoxicity in rats via attenuation of oxidative stress
Authors: Mailafiya Maryam Muhammad , Abubakar Kabeer , Chiroma Samaila Musa , Danmaigoro Abubakar , Zyoud Tawfiq Y. T. , Rahim Ezamin Bin Abdul , Moklas Mohamad Aris Mohd , Zakaria Zuki Abu Bakar 
Published: October 2022

AbstractA substantial global health burden is associated with neurotoxicity caused by lead (Pb) exposure and the common mechanism of this toxicity is mainly via oxidative damage. Curcumin has remarkable pharmacological activities but remains clinically constrained due to its poor bioavailability when orally administered. Currently, cockle shell‐derived calcium carbonate nanoparticle (CSCaCO3NP) is gaining more acceptance in nanomedicine as a nanocarrier to various therapeutics. This study aimed at investigating the ameliorative effect of curcumin‐loaded CSCaCO3NP (Cur‐CSCaCO3NP) on lead‐induced neurotoxicity in rats. A total of 36 male Sprague–Dawley rats were randomly assigned into five groups. Each group consists of 6 rats apart from the control group which consists of 12 rats. During the 4 weeks induction phase, all rats received a flat dose of 50 mg/kg of lead while the control group received normal saline. The treatment phase lasted for 4 weeks, and all rats received various doses of treatments as follows: group C (Cur 100) received 100 mg/kg of curcumin, group D (Cur‐CSCaCO3NP 50) received 50 mg/kg of Cur‐CSCaCO3NP, and group E (Cur‐CSCaCO3NP 100) received 100 mg/kg of Cur‐CSCaCO3NP. The motor function test was carried out using the horizontal bar method. The cerebral and cerebellar oxidative biomarker levels were estimated using ELISA and enzyme assay kits. Lead‐administered rats revealed a significant decrease in motor scores and SOD activities with a resultant increase in MDA levels. Furthermore, marked cellular death of the cerebral and cerebellar cortex was observed. Conversely, treatment with Cur‐CSCaCO3NP demonstrated enhanced ameliorative effects when compared with free curcumin treatment by significantly reversing the aforementioned alterations caused by lead. Thus, CSCaCO3NP enhanced the efficacy of curcumin by ameliorating the lead‐induced neurotoxicity via enhanced attenuation of oxidative stress.
Impact of prevention in primary care on costs in primary and secondary care for people with serious mental illness
Authors: Ride Jemimah , Kasteridis Panos , Gutacker Nils , Gravelle Hugh , Rice Nigel , Mason Anne , Goddard Maria , Doran Tim , Jacobs Rowena 
Published: October 2022

AbstractA largely unexplored part of the financial incentive for physicians to participate in preventive care is the degree to which they are the residual claimant from any resulting cost savings. We examine the impact of two preventive activities for people with serious mental illness (care plans and annual reviews of physical health) by English primary care practices on costs in these practices and in secondary care. Using panel two‐part models to analyze patient‐level data linked across primary and secondary care, we find that these preventive activities in the previous year are associated with cost reductions in the current quarter both in primary and secondary care. We estimate that there are large beneficial externalities for which the primary care physician is not the residual claimant: the cost savings in secondary care are 4.7 times larger than the cost savings in primary care. These activities are incentivized in the English National Health Service but the total financial incentives for primary care physicians to participate were considerably smaller than the total cost savings produced. This suggests that changes to the design of incentives to increase the marginal reward for conducting these preventive activities among patients with serious mental illness could have further increased welfare.
Postnatal development of hippocampal CA2 structure and function during the emergence of social recognition of peers
Authors: Diethorn Emma J. , Gould Elizabeth 
Published: October 2022

AbstractIt is now well‐established that the hippocampal CA2 region plays an important role in social recognition memory in adult mice. The CA2 is also important for the earliest social memories, including those that mice have for their mothers and littermates, which manifest themselves as a social preference for familiarity over novelty. The role of the CA2 in the development of social memory for recently encountered same‐age conspecifics, that is, peers, has not been previously reported. Here, we used a direct social interaction test to characterize the emergence of novelty preference for peers during development and found that at the end of the second postnatal week, pups begin to significantly prefer novel over familiar peers. Using chemogenetic inhibition at this time, we showed that CA2 activity is necessary for the emergence of novelty preference and for the ability to distinguish never encountered from recently encountered peers. In adulthood, the CA2 region is known to integrate a large number of inputs from various sources, many of which participate in social recognition memory, but previous studies have not determined whether these afferents are present at adult levels by the end of the second postnatal week. To explore the development of CA2 inputs, we used immunolabeling and retrograde adenovirus circuit tracing and found that, by the end of the second postnatal week, the CA2 is innervated by many regions, including the dentate gyrus, supramammillary nucleus of the hypothalamus, the lateral entorhinal cortex, and the median raphe nucleus. Using retroviral labeling of postnatally generated granule cells in the dentate gyrus, we found that mossy fiber projections to the CA2 mature faster during development than those generated in adulthood. Together, our findings indicate that the CA2 is partially mature in afferent connectivity by the end of the second postnatal week, connections that likely facilitate the emergence of social recognition memory and preference for novel peers.