bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strengthening primary health care: contributions of young professional-led communities of practice
Authors: Calma Kaara Ray B. , Brown Lynsey J. , Fernando G.V.M. Chamath , Omam Lundi-Anne 
Published: March 2022

Abstract

Background:
Health systems that have strong primary health care at their core have overall better patient outcomes. Primary health care is key to achieving Universal Health Coverage and the broader health-related Sustainable Development Goals by 2030. In 2018, at the launch of the Declaration of Astana, the World Health Organization formed the inaugural Primary Health Care Young Leaders’ Network.

Objective:
This paper aims to demonstrate the scope for young professional-led communities of practice in fostering support systems for young leaders and strengthening the delivery of primary health care at multiple levels.

Methods:
A description of the Young Leaders' Network community of practice model is presented, with examples of the work the members are doing, individually and collectively, to advance the science and practice of primary health care.

Results:
This initiative brought together 21 individuals from across the world, working across disciplines and within an array of socioeconomic contexts to improve primary health care in their respective countries.

Conclusions:
This youth-led community of practice is able to share knowledge, evidence and resources to inform clinical and public health activities, policy initiatives, advocacy and research to improve primary health care delivery and health outcomes for communities across the globe.
Development postcolonial: a critical approach to understanding SDGs in the perspective of Christian social ethics
Authors: Vogt Markus 
Published: March 2022

Non-technical summaryBy distinguishing between developed and less developed nations, the concept of development subtly establishes hierarchies and a supposed comparability, which is highly ambivalent from a socio-ethical point of view. The idea of holistic development in Catholic social teaching focus on cultural dimensions and therefore sets an important counter accent to the fixation on socio-technically producible and countable things. The Sustainable Development Goals (SDGs) lack a coherence between the social and the ecological components as well as a naming of power conflicts. For a power-critical, postcolonial and participatory concept of development, their interpretation could learn substantially from the encyclicalLaudato si'.Technical summaryThe paradigm of development is subjected to a radical critique in parts of the academic debate: Is the idea of development, which in a gesture of aid divides the world into “developed” and “underdeveloped” nations and thus establishes a hierarchy, still politically and morally justifiable at all? Has this concept possibly become a backdoor to prolong the old colonial power relations into the 21st century, even to increase them in some cases? Is development one of the great utopias of the 20th century that promised freedom and brought division? Is the ecological overexploitation of global resources the inevitable reverse side of the spread of the Western model of prosperity disguised as “development”? Do the SDGs act subcutaneously as enablers of Western imperial power, or do they represent a genuine paradigm shift? This article explores these questions in four steps: 1. Is the age of development is over? 2. The ideal of “integral development” – steps of a revision process 3. In the tension between ecological and social goals: A Comparison of the “Sustainable Development Goals” and the EncyclicalLaudato si' 4. Priorities and strategies of a “post-utopian development policy”.Social media summaryThe shadows of colonial thinking are still effective today in development concepts fixated on countable factors of socioeconomic efficiency.
Extratropical Shortwave Cloud Feedbacks in the Context of the Global Circulation and Hydrological Cycle
Authors: McCoy Daniel T. , Field Paul , Frazer Michelle E. , Zelinka Mark D. , Elsaesser Gregory S. , Mülmenstädt Johannes , Tan Ivy , Myers Timothy A. , Lebo Zachary J. 
Published: March 2022

AbstractShortwave (SW) cloud feedback (SWFB) is the primary driver of uncertainty in the effective climate sensitivity (ECS) predicted by global climate models (GCMs). ECS for several GCMs participating in the sixth assessment report exceed 5K, above the fifth assessment report “likely” maximum (4.5K) due to extratropical SWFB's that are more positive than those simulated in the previous generation of GCMs. Here we show that across 57 GCMs Southern Ocean SWFB can be predicted from the sensitivity of column‐integrated liquid water mass (LWP) to moisture convergence and to surface temperature. The response of LWP to moisture convergence and the response of albedo to LWP anti‐correlate across GCMs. This is because GCMs that simulate a larger response of LWP to moisture convergence tend to have higher mean‐state LWPs, which reduces the impact of additional LWP on albedo. Observational constraints suggest a modestly negative Southern Ocean SWFB— inconsistent with extreme ECS.
Bedrock Geochemistry and Alteration History of the Clay‐Bearing Glen Torridon Region of Gale Crater, Mars
Authors: Dehouck Erwin , Cousin Agnès , Mangold Nicolas , Frydenvang Jens , Gasnault Olivier , Forni Olivier , Rapin William , Gasda Patrick J. , Caravaca Gwénaël , David Gaël , Bedford Candice C. , Lasue Jérémie , Meslin Pierre‐Yves , Rammelkamp Kristin , Desjardins Marine , Le Mouélic Stéphane , Thorpe Michael T. , Fox Valerie K. , Bennett Kristen A. , Bryk Alexander B. , Lanza Nina L. , Maurice Sylvestre , Wiens Roger C. 
Published: March 2022

AbstractGlen Torridon is a topographic trough located on the slope of Aeolis Mons, Gale crater, Mars. It corresponds to what was previously referred to as the “clay‐bearing unit,” due to the relatively strong spectral signatures of clay minerals (mainly ferric smectites) detected from orbit. Starting in January 2019, the Curiosity rover explored Glen Torridon for more than 700 sols (Martian days). The objectives of this campaign included acquiring a detailed understanding of the geologic context in which the clay minerals were formed, and determining the intensity of aqueous alteration experienced by the sediments. Here, we present the major‐element geochemistry of the bedrock as analyzed by the ChemCam instrument. Our results reveal that the two main types of bedrock exposures identified in the lower part of Glen Torridon are associated with distinct chemical compositions (K‐rich and Mg‐rich), for which we are able to propose mineralogical interpretations. Moreover, the topmost stratigraphic member exposed in the region displays a stronger diagenetic overprint, especially at two locations close to the unconformable contact with the overlying Stimson formation, where the bedrock composition significantly deviates from the rest of Glen Torridon. Overall, the values of the Chemical Index of Alteration determined with ChemCam are elevated by Martian standards, suggesting the formation of clay minerals through open‐system weathering. However, there is no indication that the alteration was stronger than in some terrains previously visited by Curiosity, which in turn implies that the enhanced orbital signatures are mostly controlled by non‐compositional factors.
Quantum steering with vector vortex photon states with the detection loophole closed
Authors: Slussarenko Sergei , Joch Dominick J. , Tischler Nora , Ghafari Farzad , Shalm Lynden K. , Verma Varun B. , Nam Sae Woo , Pryde Geoff J. 
Published: March 2022

AbstractViolating a nonlocality inequality enables the most powerful remote quantum information tasks and fundamental tests of quantum physics. Loophole-free photonic verification of nonlocality has been achieved with polarization-entangled photon pairs, but not with states entangled in other degrees of freedom. Here we demonstrate completion of the quantum steering nonlocality task, with the detection loophole closed, when entanglement is distributed by transmitting a photon in an optical vector vortex state, formed by optical orbital angular momentum (OAM) and polarization. As well as opening up a high-efficiency encoding beyond polarization, the critically important demonstration of vector vortex steering opens the door to new free-space and satellite-based secure quantum communication devices and device-independent protocols.
Recovery time of a plasma-wakefield accelerator
Authors: D’Arcy R. , Chappell J. , Beinortaite J. , Diederichs S. , Boyle G. , Foster B. , Garland M. J. , Caminal P. Gonzalez , Lindstrøm C. A. , Loisch G. , Schreiber S. , Schröder S. , Shalloo R. J. , Thévenet M. , Wesch S. , Wing M. , Osterhoff J. 
Published: March 2022

AbstractThe interaction of intense particle bunches with plasma can give rise to plasma wakes1,2capable of sustaining gigavolt-per-metre electric fields3,4, which are orders of magnitude higher than provided by state-of-the-art radio-frequency technology5. Plasma wakefields can, therefore, strongly accelerate charged particles and offer the opportunity to reach higher particle energies with smaller and hence more widely available accelerator facilities. However, the luminosity and brilliance demands of high-energy physics and photon science require particle bunches to be accelerated at repetition rates of thousands or even millions per second, which are orders of magnitude higher than demonstrated with plasma-wakefield technology6,7. Here we investigate the upper limit on repetition rates of beam-driven plasma accelerators by measuring the time it takes for the plasma to recover to its initial state after perturbation by a wakefield. The many-nanosecond-level recovery time measured establishes the in-principle attainability of megahertz rates of acceleration in plasmas. The experimental signatures of the perturbation are well described by simulations of a temporally evolving parabolic ion channel, transferring energy from the collapsing wake to the surrounding media. This result establishes that plasma-wakefield modules could be developed as feasible high-repetition-rate energy boosters at current and future particle-physics and photon-science facilities.
Southern ocean sea level anomaly in the sea ice-covered sector from multimission satellite observations
Authors: Auger Matthis , Prandi Pierre , Sallée Jean-Baptiste 
Published: March 2022

AbstractDespite its central role in the global climate, the Southern Ocean circulation is still one of the least understood ocean circulation systems of the planet. One major constraint to our understanding of this region is the challenge of observing ocean circulation in the seasonally sea ice sector of the Southern Ocean. Here, we present a new Sea Level Anomaly (SLA) product, focusing on the subpolar Southern Ocean and including its sea ice covered parts from 2013 to 2019. Combining observations from multiple satellites, including Cryosat-2, Sentinel-3A, and SARAL/AltiKa, processed with state-of-the-art algorithms, allows an improvement in spatial and temporal resolution compared with previous products. Validation is made by comparing our estimate with existing SLA products, cross-comparing estimates from individual satellites in the sea ice zones, and comparing the time series of the product with a Bottom Pressure Recorder in the Drake Passage.
Revealing inscriptions obscured by time on an early-modern lead funerary cross using terahertz multispectral imaging
Authors: Dong Junliang , Ribeiro Ana , Vacheret Aurélien , Locquet Alexandre , Citrin D. S. 
Published: March 2022

AbstractThe presence of a corrosion layer on lead art and archæological objects can severely impede the interpretation of inscriptions, thus hampering our overall understanding of the object and its context. While the oxidation of lead that dominates corrosion may be chemically reversible via reduction, potentially providing some access to inscriptions otherwise obscured by time, corrosion damage is overall neither entirely reversible nor is the reduction process in all cases easy or feasible to carry out. In this study, by taking advantage of the unique penetration ability of terahertz radiation and the abundant frequency bands covered by a single-cycle terahertz pulse, we perform nondestructive terahertz multispectral imaging to look under the corrosion on a sixteenth century lead funerary cross (croix d’absolution) from Remiremont in Lorraine, France. The multispectral images obtained from various terahertz frequency bands are fed into a judiciously designed post-processing chain for image restoration and enhancement, thus allowing us for the first time to read obscured inscriptions that might have otherwise been lost. Our approach, which brings together in a new way the THz properties of the constituent materials and advanced signal- and image-processing techniques, opens up new perspectives for multi-resolution analysis at terahertz frequencies as a technique in archæometry and will ultimately provide unprecedented information for digital acquisition and documentation, character extraction, classification, and recognition in archæological studies.
Microbiome and metabolome profiles of high screen time in a cohort of healthy college students
Authors: Jasbi Paniz , Mohr Alex E. , Shi Xiaojian , Mahmood Tara , Zhu Qiyun , Bruening Meg , Gu Haiwei , Whisner Corrie 
Published: March 2022

AbstractAs screens are increasingly integrated into every facet of modern life, there is growing concern over the potential effects of high screen time. Previous studies have largely utilized self-report data on mood and behavioral aspects of screen time, and no molecular theory has yet been developed. In this study, we explored the fecal microbiome and metabolome of a diverse group of 60 college students, classified by high (≥ 75 min/day) or low (0–75 min/day) self-reported screen time using 16S rRNA amplicon sequencing, targeted liquid chromatography-tandem mass spectrometry, and targeted detection of short-chain fatty acids using gas chromatography-mass spectrometry. Several key taxa and metabolites were significantly altered between groups and found to be highly co-occurrent. Results of pathway and enzyme enrichment analyses were synthesized to articulate an integrated hypothesis indicating widespread mitochondrial dysfunction and aberrant amino acid metabolism. High screen time was also predicted to be significantly associated with type I diabetes, obesity, chronic fatigue syndrome, and various manifestations of inflammatory bowel. This is the first-ever study to report the effects of high screen time at the molecular level, and these results provide a data-driven hypothesis for future experimental research.
Early cardiac-chamber-specific fingerprints in heart failure with preserved ejection fraction detected by FTIR and Raman spectroscopic techniques
Authors: Tombolesi Niki , Altara Raffaele , da Silva Gustavo J. J. , Tannous Cynthia , Zouein Fouad A. , Stensløkken Kåre-Olav , Morresi Assunta , Paolantoni Marco , Booz George W. , Cataliotti Alessandro , Sassi Paola 
Published: March 2022

AbstractThe pathophysiology of heart failure with preserved ejection fraction (HFpEF) is a matter of investigation and its diagnosis remains challenging. Although the mechanisms that are responsible for the development of HFpEF are not fully understood, it is well known that nearly 80% of patients with HFpEF have concomitant hypertension. We investigated whether early biochemical alterations were detectable during HFpEF progression in salt-induced hypertensive rats, using Fourier-transformed infrared (FTIR) and Raman spectroscopic techniques as a new diagnostic approach. Greater protein content and, specifically, greater collagen deposition were observed in the left atrium and right ventricle of hypertensive rats, together with altered metabolism of myocytes. Additionally, Raman spectra indicated a conformational change, or different degree of phosphorylation/methylation, in tyrosine-rich proteins. A correlation was found between tyrosine content and cardiac fibrosis of both right and left ventricles. Microcalcifications were detected in the left and right atria of control animals, with a progressive augmentation from six to 22 weeks. A further increase occurred in the left ventricle and right atrium of 22-week salt-fed animals, and a positive correlation was shown between the mineral deposits and the cardiac size of the left ventricle. Overall, FTIR and Raman techniques proved to be sensitive to early biochemical changes in HFpEF and preceded clinical humoral and imaging markers.
A hierarchy in clusters of cephalopod mRNA editing sites
Authors: Moldovan Mikhail A. , Chervontseva Zoe S. , Nogina Daria S. , Gelfand Mikhail S. 
Published: March 2022

AbstractRNA editing in the form of substituting adenine with inosine (A-to-I editing) is the most frequent type of RNA editing in many metazoan species. In most species, A-to-I editing sites tend to form clusters and editing at clustered sites depends on editing of the adjacent sites. Although functionally important in some specific cases, A-to-I editing usually is rare. The exception occurs in soft-bodied coleoid cephalopods, where tens of thousands of potentially important A-to-I editing sites have been identified, making coleoids an ideal model for studying of properties and evolution of A-to-I editing sites. Here, we apply several diverse techniques to demonstrate a strong tendency of coleoid RNA editing sites to cluster along the transcript. We show that clustering of editing sites and correlated editing substantially contribute to the transcriptome diversity that arises due to extensive RNA editing. Moreover, we identify three distinct types of editing site clusters, varying in size, and describe RNA structural features and mechanisms likely underlying formation of these clusters. In particular, these observations may explain sequence conservation at large distances around editing sites and the observed dependency of editing on mutations in the vicinity of editing sites.
Interaction of thin polyethyleneimine layer with the iron surface and its effect on the electrochemical behavior
Authors: Gorejová Radka , Podrojková Natália , Sisáková Katarína , Shepa Jana , Shepa Ivan , Kovalčíková Alexandra , Šišoláková Ivana , Kaľavský František , Oriňaková Renáta 
Published: March 2022

AbstractPolymer-coated metals may act as biodegradable orthopedic implants with adjustable corrosion rates. Metallic surfaces represent a dynamic system with specific interactions occurring after the material is implanted into the human body. An additional layer, in the form of polymeric thin film, changes the nature of this metal-body fluids interface. Moreover, the interaction between polymer and metal itself can differ for various systems. Iron-based material modified with a thin layer of polyethyleneimine (PEI) coating was prepared and studied as potential absorbable implant. Computational methods were employed to study the interaction between the metallic surface and polymer functional monomer units at atomic levels. Various spectroscopical and optical methods (SEM, AFM, Confocal, and Raman spectroscopy) were also used to characterize prepared material. Electrochemical measurements have been chosen to study the polymer adsorption process onto the iron surface and corrosion behavior which is greatly influenced by the PEI presence. The adsorption mechanism of PEI onto iron was proposed alongside the evaluation of Fe and Fe-PEI degradation behavior studied using the impedance method. Bonding via amino -NH2 group of PEI onto Fe and enhanced corrosion rate of coated samples were observed and confirmed.
Cross compatibility in intraspecific and interspecific hybridization in yam (Dioscorea spp.)
Authors: Mondo Jean M. , Agre Paterne A. , Edemodu Alex , Asiedu Robert , Akoroda Malachy O. , Asfaw Asrat 
Published: March 2022

AbstractYam (Dioscorea spp.) is a staple crop for millions of people in the tropics and subtropics. Its genetic improvement through breeding is being challenged by pre-zygotic and post-zygotic cross-compatibility barriers within and among species. Studies dissecting hybridization barriers on yam for improving the crossability rates are limited. This study aimed to assess the cross-compatibility, which yielded fruit set, viable seeds and progeny plants in an extensive intraspecific and interspecific crossing combinations in a yam genetic improvement effort to understand the internal and exogenous factors influencing pollination success. Cross-compatability was analyzed at the individual genotype or family level using historical data from crossing blocks and seedling nurseries from 2010 to 2020 at the International Institute of Tropical Agriculture (IITA). The average crossability rate (ACR) was lower in interspecific crossing combinations (6.1%) than intraspecific ones (27.6%). The seed production efficiency (SPE) values were 1.1 and 9.3% for interspecific and intraspecific crosses, respectively. Weather conditions and pollinator's skills are the main contributors to the low success rate in the intraspecific cross combinations in yam breeding. At the same time, genetic distance and heterozygosity played little role. Interspecific cross barriers were both pre-zygotic and post-zygotic, resulting from the evolutionary divergence among the yam species. Dioscorea rotundata had higher interspecific cross-compatibility indices than D. alata. Distant parents produced intraspecific crossbred seeds with higher germination rates compared to closest parents (r = 0.21, p = 0.033). This work provided important insights into interspecific and intraspecific cross-compatibility in yam and suggested actions for improving hybridization practices in yam breeding programs.
Methylation of recombinant mononucleosomes by DNMT3A demonstrates efficient linker DNA methylation and a role of H3K36me3
Authors: Bröhm Alexander , Schoch Tabea , Dukatz Michael , Graf Nora , Dorscht Franziska , Mantai Evelin , Adam Sabrina , Bashtrykov Pavel , Jeltsch Albert 
Published: March 2022

AbstractRecently, the structure of the DNMT3A2/3B3 heterotetramer complex bound to a mononucleosome was reported. Here, we investigate DNA methylation of recombinant unmodified, H3KC4me3 and H3KC36me3 containing mononucleosomes by DNMT3A2, DNMT3A catalytic domain (DNMT3AC) and the DNMT3AC/3B3C complex. We show strong protection of the nucleosomal bound DNA against methylation, but efficient linker-DNA methylation next to the nucleosome core. High and low methylation levels of two specific CpG sites next to the nucleosome core agree well with details of the DNMT3A2/3B3-nucleosome structure. Linker DNA methylation next to the nucleosome is increased in the absence of H3K4me3, likely caused by binding of the H3-tail to the ADD domain leading to relief of autoinhibition. Our data demonstrate a strong stimulatory effect of H3K36me3 on linker DNA methylation, which is independent of the DNMT3A-PWWP domain. This observation reveals a direct functional role of H3K36me3 on the stimulation of DNA methylation, which could be explained by hindering the interaction of the H3-tail and the linker DNA. We propose an evolutionary model in which the direct stimulatory effect of H3K36me3 on DNA methylation preceded its signaling function, which could explain the evolutionary origin of the widely distributed “active gene body-H3K36me3-DNA methylation” connection.