bluuebunny/crossref_metadata_2025_split huggingface dataset:
La pratique dédicatoire du dramaturge Pierre du Ryer : vers un « lieu vide du pouvoir »  ?
Authors: Pocquet Tiphaine 
Published: July 2022

Les épîtres préfacielles précédant le théâtre de Pierre du Ryer connaissent une évolution significative, le dramaturge choisit des figures puissantes mais également contestataires (celle de César de Vendôme), puis abandonne la pratique dédicatoire. Un texte préfaciel fait charnière : la dédicace de la tragédie Saül à « personne » c’est-à-dire à tout le monde, en 1642. Il s’agit pour nous de comprendre ce geste de dédicace universelle en partant des circonstances politiques de ce choix. Nous montrons qu’en perdant le principe d’une autorité unique – la figure du dédicataire traditionnel et derrière elle, celle du souverain dispensateur des dons – la puissance se déplace pour se loger dans un lien élargi, tissé avec un public de lecteurs particuliers et pluriels en même temps. Le texte préfaciel devient ce « lieu vide du pouvoir », aux contours sans cesse redéfinis.
Photographic coverage of the Trou de la Féclaz site (Saint-Jean-d’Arvey, Savoy, France) — data paper
Authors: Defrasne Claudia 
Published: July 2022

The dataset described in this paper consists of 557 photographs composing the 2D photographic coverage of the rock paintings from the Trou de la Féclaz alpine site (Saint-Jean-d’Arvey, Savoy, France) with 14 pictures of the environment of the site and 21 pictures composing the general views of the rockshelter. This record was carrying out as part of a post-doctoral research at Aix-Marseille Université on the structure and chronology of the prehistoric schematic rock paintings from southern France and western Alps, a corpus today composed of 146 sites. This was administratively authorized both by the municipality that is the owner of the site, and the Regional Service of Archaeology Auvergne-Rhône-Alpes that also financially supported the fieldwork.
Genome-Wide Mapping of Plasma IgG N-Glycan Quantitative Trait Loci Identifies a Potentially Causal Association between IgG N-Glycans and Rheumatoid Arthritis
Authors: Liu Di , Dong Jing , Zhang Jie , Xu Xizhu , Tian Qiuyue , Meng Xiaoni , Wu Lijuan , Zheng Deqiang , Chu Xi , Wang Wei , Meng Qun , Wang Youxin 
Published: July 2022

Abstract
Observational studies highlight associations of IgG N-glycosylation with rheumatoid arthritis (RA); however, the causality between these conditions remains to be determined. Standard and multivariable two-sample Mendelian randomization (MR) analyses integrating a summary genome-wide association study for RA and IgG N-glycan quantitative trait loci (IgG N-glycan-QTL) data were performed to explore the potentially causal associations of IgG N-glycosylation with RA. After correcting for multiple testing (p &lt; 2 × 10−3), the standard MR analysis based on the inverse-variance weighted method showed a significant association of genetically instrumented IgG N-glycan (GP4) with RA (odds ratioGP4 = 0.906, 95% confidence interval = 0.857–0.958, p = 5.246 × 10−4). In addition, we identified seven significant associations of genetically instrumented IgG N-glycans with RA by multivariable MR analysis (p &lt; 2 × 10−3). Results were broadly consistent in sensitivity analyses using MR_Lasso, MR_weighted median, MR_Egger regression, and leave-one-out analysis with different instruments (all p values &lt;0.05). There was limited evidence of pleiotropy bias (all p values &gt; 0.05). In conclusion, our MR analysis incorporating genome-wide association studies and IgG N-glycan-QTL data revealed that IgG N-glycans were potentially causally associated with RA. Our findings shed light on the role of IgG N-glycosylation in the development of RA. Future studies are needed to validate our findings and to explore the underlying physiological mechanisms in the etiology of RA.
High-Fat Diet–Induced Obesity Alters Dendritic Cell Homeostasis by Enhancing Mitochondrial Fatty Acid Oxidation
Authors: Chen I-Chun , Awasthi Deepika , Hsu Chia-Lang , Song Minkyung , Chae Chang-Suk , Dannenberg Andrew J , Cubillos-Ruiz Juan R 
Published: July 2022

Abstract
Obesity is associated with increased cancer risk and weak responses to vaccination and sepsis treatment. Although dendritic cells (DCs) are fundamental for the initiation and maintenance of competent immune responses against pathogens and tumors, how obesity alters the normal physiology of these myeloid cells remains largely unexplored. In this study, we report that obesity caused by prolonged high-fat diet feeding disrupts the metabolic and functional status of mouse splenic DCs (SpDCs). High-fat diet–induced obesity drastically altered the global transcriptional profile of SpDCs, causing severe changes in the expression of gene programs implicated in lipid metabolism and mitochondrial function. SpDCs isolated from obese mice demonstrated enhanced mitochondrial respiration provoked by increased fatty acid oxidation (FAO), which drove the intracellular accumulation of reactive oxygen species that impaired Ag presentation to T cells. Accordingly, treatment with the FAO inhibitor etomoxir, or antioxidants such as vitamin E or N-acetyl-l-cysteine, restored the Ag-presenting capacity of SpDCs isolated from obese mice. Our findings reveal a major detrimental effect of obesity in DC physiology and suggest that controlling mitochondrial FAO or reactive oxygen species overproduction may help improve DC function in obese individuals.
A Comparative Examination of Cyclic Fatigue and Fragment Length of Three Different Types of Endodontic Rotary Files
Authors: Abduljabbar Saleh Hanaa , Husham Abdulhameed Othman 
Published: July 2022

Introduction:
Although of great scientific advancement in the properties and form, fracture of nickel-titanium (NiTi) files could occur during their use. The goal of this study was to compare resistance to cyclic fatigue of various rotary systems used in endodontics.

Materials and Methods:
Three types of NiTi rotary systems were tested – group A: One Curve, group B: Edge File, and group C: lusterdent NiTi files. In these files, taper is 0.06, and their diameter is 25 mm. Stainless steel block was used. This block contains artificial canals with a 60o curvature, 5 mm radius of curvature, 21 mm length, and 1.5 mm width. A number of cycles before fracture were obtained and measurement of fragment length was achieved. Statistical evaluation of readings was accomplished with ANOVA and Tukey post hoc test.

Results:
There were statistically significant differences between the three types of NiTi rotary systems considering the number of cycles before file fracture (P < 0.001). The differences between fracture lengths were not statistically significant (P = 0.15).

Conclusion:
The Edge File revealed the highest cyclic fatigue resistance.
Evaluation of Friction and Surface Characteristics of Two Types of Self-Ligating Bracket Gate
Authors: Kanbar Hussein A. , Obaid Dina H. , Ibrahim Ali I. 
Published: July 2022

Introduction:
Frictional forces generation during orthodontic treatment with fixed appliances impedes appropriate tooth movement; hence, research is ongoing to explore “frictionless” techniques. This in vitro study compares Damon Q and Pactive self-ligating metallic brackets in terms of friction and surface characteristics of the bracket gates when using CuNiTi archwires during leveling and alignment stage and examines the effects of aging conditions on frictional force generation.

Methods:
A total of 108 metallic self-ligating brackets (Damon Q and Pactive) were investigated for frictional resistance with round 0.014″ and rectangular 0.014″*0.025″ CuNiTi archwires post exposure to water storage and acidic attack aging conditions. The bracket gate surface characteristics were evaluated using scanning electron microscope (SEM).

Results:
There was no statistically significant difference (P > 0.05) in friction generation between the two bracket systems when coupled with 0.014″ CuNiTi archwire, but the Pactive brackets yielded significantly higher frictional forces (P < 0.05) when coupled with 0.014″*0.025″ archwire. The SEM findings revealed nonsignificant differences (P > 0.05) between the surface characteristics of the bracket gates.

Conclusions:
Damon Q brackets generate low frictional forces, suggesting better performance than Pactive brackets during the first phase of orthodontic treatment. A modified scoring system was developed for an objective description of bracket surface characteristics.
Microleakage Evaluation of Glass Hybrid Restoration Following Usage of Papain-Based Gel and Ceramic Bur for Caries Removal
Authors: Alkhawaja Halah Abdulkareem A. , Al Haidar Aseel Haidar M.J. 
Published: July 2022

Introduction:
In the field of pediatric dentistry, an urge to adopt a more comfortable, minimally invasive, and stressless technique for caries removal became a must. Coronavirus disease-2019 outbreak necessitates a paradigm change in the global health care protocols, requiring alternative, nonaerosol generating approaches. This study aimed to measure and compare the influence of two methods of caries removal, namely, Brix3000 and CeraBur, on the microleakage of glass hybrid restorative material.

Materials and Methods:
Thirty human primary molar teeth with accessible occluso-gingival carious cavitation were randomly allocated into CeraBur and Brix3000 groups. After selective caries excavation, samples were restored with Equia Forte HT, thermocycled, dipped in thiazine dye, washed, and sectioned through the restoration center. Then microleakage was measured using a stereomicroscope (30× magnification) at both occlusal and gingival margins.

Results:
No statistically significant difference was found between the two methods of caries removal (CeraBur and Brix3000) at both occlusal (P = 1.000) and gingival margins (P = 0.612).

Conclusions:
Brix3000 caries removing gel did not negatively affect the microleakage of Equia Forte HT compared to the CeraBur and hence can be used alternatively to the conventional drilling methods.
Filling Ability of Various Root Canal Sealers into Simulated Lateral Canals
Authors: Alalaf Nur Ayad , Alkhalidi Emad Farhan 
Published: July 2022

Background:
This study aimed to assess and compare the depth of penetration of TotalFill BC, AH Plus Jet, and GuttaFlow Bioseal sealers into simulated lateral canals.

Materials and Methods:
A total of 30 extracted mandibular premolars were selected. Simulated lateral canals were made. The specimens were randomized into three experimental groups of 10 each. The specimens were cleared for visualization under a stereomicroscope at 10× magnification. The depth of penetration was assessed by a four-grade scoring system. Data were submitted to Fisher exact test at 5% significance.

Results:
There was statistically no significant difference among the experimental groups regarding the depth of penetration (P > .05).

Conclusion:
All root canal sealers experimented with herein showed a comparable depth of penetration in the simulated lateral canals regarding their filling ability.
A Comparison of the Marginal Accuracy of Metal Copings Made with Three Different Brands of Nickel–Chromium Alloys and Various Sprue Designs
Authors: Rashidi Tabish , Bhasin Navreet , Bumb Pratik P. , Singh Amitu , Pawar Shubhra J. , Priyadarshi Siddharth 
Published: July 2022

Introduction:
It is important to construct the sprue in a way that ensures that the mold gets an appropriate supply of metal at the right speed. Many manufacturers now offer sprue designs that have not been advocated in textbooks or publications for their normal use.

Aim:
The goal of this research was to compare the sprue design's marginal fit to that of the other designs.

Methods:
During this investigation, we attempted to see whether the fabrication of metal copings could be improved. Three sprue designs were used in this research for the assessment of casting accuracy: normal cylindrical, funnel-shaped, and cuboidal or flattened sprue forms.

Results:
The mean marginal disparity of nickel–chromium (Ni–Cr) alloy copings made by three distinct brands was determined to be statistically insignificant.

Conclusion:
Within the limitation of the study, it was concluded that the marginal accuracy of metal copings fabricated with three different brands of Ni–Cr alloy did not reveal a statistically significant result. However, out of the three different sprue designs, that is, cylindrical, cuboidal, and funnel shape, the marginal accuracy of cylindrical and cuboidal sprue designs was found to be better than that of the funnel shape sprue design because the funnel shape sprue design is narrow at the point of attachment, thereby increasing the flow pressure and decreasing the turbulence of the molten metal.
Demineralized Freeze-Dried Bone and Modified Hydroxyapatite Granules in Patients Requiring Immediate Dental Implants
Authors: Pragna K , Bulkar Vikas , Naveen Reddy R , Jamal Sayed Arshad , Zahir Hussain Mohammed Abid , Khader Anas Abdul 
Published: July 2022

Objectives:
The objective is to compare demineralized freeze-dried bone and modified hydroxyapatite granules in patients requiring immediate dental implants.

Materials and Methods:
Forty patients for immediate dental implants were divided into Group I (demineralized freeze-dried bone allograft) and Group II (modified hydroxyapatite) based on the type of graft used. Success of graft was evaluated based on modified plaque index, gingival index, and Periotest at 3, 6, and 12 months follow up.

Results:
The mean modified plaque index, gingival index, peri-implant sulcular depth, and Periotest were recorded at baseline, 3, 6, and 12 months at implant site and full mouth in both groups found to be nonsignificant (P > 0.05).

Conclusion:
Both demineralized freeze-dried bone allograft and modified hydroxyapatite grafts were equally efficient in immediate dental implant placement sites.
Comparative Evaluation of Efficacy of Bioactive Glass, Tricalcium Phosphate, and Ozone Remineralizing Agents on Artificial Carious Lesion
Authors: Jena Debkant , Manas Abhigyan , Venkateswararao CH , Salama Mohamed Tharwat , Ismail Prabu Mahin Syed , Basha Shaik Riyaz 
Published: July 2022

Objectives:
Evaluation of efficacy of bioactive glass (BAG), tricalcium phosphate, and ozone remineralizing agents on artificial carious lesion.

Materials and Methods:
Freshly extracted 48 human premolar teeth were included for this in vitro study. Remineralization of demineralized teeth was done with respective remineralizing agents (Group A – calcium sodium phosphosilicate [BAG], Group B – tricalcium phosphate [Clinpro Tooth Crème], Group C – ozone remineralizing agents, and control group: Group D – deionized water) three times a day for 12 days for 4 min. The degree of demineralization and remineralization was evaluated with Vickers hardness number.

Results:
There was a decrease in microhardness from baseline to demineralization in all the groups. The difference in microhardness values from demineralization to remineralization in all the three test groups was found to be statistically highly significant.

Conclusion:
BAG and Tricalcium phosphate had higher remineralizing capacity, which can be used clinically to treat early carious lesions.
Comparative Evaluation of Apical Sealing Efficacy of Guttaflow Bioseal, Super-Bond Rc Sealer and Adseal Root Canal Sealer
Authors: Mueen Ahmed Syed , Sorte Gawali Kranti , Paul Princy , Ismail Prabu Mahin Syed , Abdullah Alkhelaiwi Arwa , Abdullah Alkhelaiwi Mohammed 
Published: July 2022

Objectives:
The objectives of this study is to evaluate apical sealing ability of GuttaFlow Bioseal, Super-Bond RC Sealer, and Adseal root canal sealer.

Material and Methods:
36 extracted human single rooted permanent teeth, divided into three groups (n = 12) and obturated by lateral condensation technique. Obturation and root canal sealing was done by either Group I: using GuttaFlow Bioseal, Group II: using Super-Bond RC Sealer and Group III: using Adseal sealer, system. Microleakage was assessed by means of dye penetration method.

Results:
The dye penetration in Group II was more than in Groups I and III in both vertical and horizontal directions, suggesting that GuttaFlow Bioseal and Adseal sealer are effective in reducing the apical leakage compared to Super-Bond RC Sealer.

Conclusion:
Bioceramic GuttaFlow Bioseal root canal sealers seal are better root canal sealer but they cannot totally eliminate apical leakage.
Evaluation of Knowledge About Antibiotics Prescription During Periodontal Therapy Among Dental Students
Authors: Moin Ahmed Muzammil 
Published: July 2022

Background and Objective:
Despite the fact that antibiotics and analgesics are regularly prescribed by dentists, little is known regarding the dental practitioners' knowledge and comprehension of their usage in daily clinical practice. A lack of sufficient training for dental students is a possible cause of prescription mistakes. For the purpose of determining whether dental students are capable of rationally prescribing antibiotics by the time they graduate, this research examined dental students' understanding of administering antibiotics.

Methods:
The dentistry students' understanding of prescription antibiotics was assessed by means of a questionnaire. Participants in this research were undergraduates in their third and fourth year of Buraydah Private College of Dentistry and Pharmacy. Students at college were asked to fill out a standardized questionnaire.

Results:
The majority of antibiotics provided were in the right dosage and dosage form, although the frequency and length of treatment varied widely. Some 75.3% of the time, amoxicillin was administered in this research, followed by metronidazole (6.2%), tetracycline (4.1%), and erythromycin (3.2%).

Conclusion:
Continuing education on the sensible use of antibiotics in dental infections is essential, and it is best when this is done in conjunction with its use in clinical settings. To ensure that dentistry students are competent and responsible prescribers of antibiotics at the time of graduation, prescription guidelines are needed.
A study of the COVID-19 pandemic's knowledge and impact on ongoing fixed orthodontic treatment in adults
Authors: Kumar Barun D. , Pragya Prakhar , Saurabh Sandeep , Datta Archita , Sangal Shikha , Anjum Afroz , Kumar Amit , Badiyani Bhumika K. 
Published: July 2022

Background:
Due to the characteristics of dental practices and hospitals, all dental professionals, including orthodontists, are at an elevated peril of SARS-CoV-2 infection. If adequate safety actions are not taken, cross-contamination risk among dentists, orthodontists, and patients can be extremely high. For orthodontic patients, a high level of cognizance and consideration of the COVID-19 epidemic is required. The goal of this study was to assess adult patients' knowledge of the coronavirus disease 2019 (COVID-19) pandemic and its impact on their continuing fixed orthodontic treatment.

Methodology:
A cross-sectional in addition to a descriptive survey of 100 adult patients enduring fixed orthodontic treatment was done. All of the candidates were over the age of 18 years and were in lockdown due to the COVID-19 epidemic, with no therapy available.

Results:
Among the patients, 35% were male and 65% were female; 22.3% were unaware that the COVID-19 virus unfurls speedily in a dental setting; 64.8% were unquestionably keen to disclose their status and undertake pretreatment screening; 71.3% were undeniably prepared to stick to stringent appointment timings for passable sanitization of the clinical area; 70% believed that skipping appointments all through the COVID-19 pandemic would be costly; 70% believed that skipping appointments during the pandemic would prolong the treatment; and 59% thought of financial burden.

Conclusion:
COVID-19 cross-infection was not known to all adult orthodontic patients. The vast majority were aware of the situation and eager to follow infection-prevention guidelines. COVID-19 had a psychological and financial impact on patients' perceptions of overall orthodontic therapy.
Bionanocomposites in Caries Prevention and Treatment
Authors: Abuzenada Basem Mohammed , Sonbul Helal M. 
Published: July 2022

Objective:
The aim of this systematic review was to assess the therapeutic effect of remineralizing and antibacterial potential of resin-based nanocomposites compared with conventional composite with/without fluoride release in naturally occurring and post-orthodontic carious lesions.

Data Sources:
The literature search covered the electronic databases, such as PubMed, EBSCO, and Google scholar, from 2012 to 2021. Only articles published in English were included. Randomized controlled trials (RCT) and in-vitro studies were included. All studies which met eligibility criteria were reviewed by two independent reviewers.

Study Selection:
The processes involved in the selection of studies were presented in Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines for study screening. Finally, based on the eligibility criteria, 13 studies were selected. The remineralizing effects of nanocomposites were compared with conventional composites in clinical trials and in-vitro studies.

Conclusion:
Nanotechnological interventions could be used to improve the therapeutic efficiency in reducing demineralization and growth of the biofilm. Further well-designed clinical trials with long-term follow-up are essential to elucidate the clinical relevance of remineralizing agents.
Evaluation of Dimensional Stability and Surface Hardness of Interocclusal Recording Materials at Various Time Intervals
Authors: Kumar Prince , Pacharne Ajay Pravin , Mishra Sunil Kumar 
Published: July 2022

Aim:
At different timings, assessment and comparison of the dimensional stability and surface hardness of three interocclusal recording materials (IRM).

Materials and Methods:
Samples of polyvinyl siloxane, ZOE, and bite registration wax were made using stainless steel die. Each group had 10 samples. At 1, 8, 24, and 48 h, the samples were estimated using a 10× amplification stereo microscope.

Results:
Four readings were taken for each sample, the mean was considered to scale the dimensional change and surface hardness. At 1, 8, 24, and 48 h mean dimensional change was viewed as the most extreme among group 3 followed by group 2 and afterward group 1 (P < 0.05).

Conclusion:
Polyvinyl siloxane was the steadiest, most precise, and had the most noteworthy surface hardness among the three interocclusal materials.
Correlation between Diabetic Retinopathy and Diabetic Peripheral Neuropathy in Patients with Type II Diabetes Mellitus
Authors: Hafeez Mohammed , Achar Prashanthkumar , Neeralagi Meghana , Naik Gajaraj T. 
Published: July 2022

Background and Objectives:
The two most common complications of diabetes mellitus are retinopathy and neuropathy which are dealt by two different medical departments. Early detection and management are therefore necessary to prevent progression of these two diseases and will give a knowledgeable idea regarding the both. Thus, this study was done to know the association of diabetic peripheral neuropathy and diabetic retinopathy.

Methods:
This was a cross sectional study comprised of 200 cases of type 2 diabetes mellitus selected from the ophthalmology department and referred cases from other departments. A thorough history and examination was done in both departments, that is, complete ophthalmic and neurological examination respectively. Relevant investigations, if needed, were done and diabetic retinopathy was classified according to ETDRS classification.

Results:
Of the 200 patients having type 2 diabetes for more than 5 years, 28% of cases had diabetic retinopathy and 59% of cases had peripheral neuropathy. Peripheral neuropathy was twice more common than retinopathy. 33.1% had retinopathy and 65.46% had peripheral neuropathy among the uncontrolled diabetics. The prevalence of retinopathy increased 1.3 times in patients with neuropathy (16%) than in patients without peripheral neuropathy (12%).

Conclusion:
As there was higher incidence of peripheral neuropathy, it is important as ophthalmologists to look for peripheral neuropathy in diabetics which will help in reducing diabetes-related morbidities.