bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancréatite aiguë médicamenteuse secondaire à la 6-mercaptopurine : à propos d’un cas
Authors: Oubaha Sofia , Eddoukani Imane , Samlani Zohour , Krati Khadija 
Published: February 2022

Introduction : Les patients porteurs de maladies inflammatoires chroniques de l’intestin semblent être à risque élevé de pancréatite aiguë ou chronique. Cette complication peut s’intégrer dans le cadre des manifestations extra-intestinales de ces pathologies mais dans la plupart des cas décrits, elle survient suite à un traitement immunosuppresseur (azathioprine/6mercaptopurine). Observation : Patiente âgée de 44 ans porteuse d’une rectocolite hémorragique révélée par une poussée minime selon le score de Truelove et Witts, traitement par mésalazine par voie orale avec bonne évolution, ayant présenté une seconde poussée jugée sévère en pancolite. La rémission a été obtenue grâce à la corticothérapie injectable pendant 5 jours puis relais par voie orale. Pour maintenir la rémission, la 6-mercaptopurine a été démarrée à la dose de 1,5 mg/Kg/j après un bilan pré-immunosuppresseur normal. L’évolution a été marquée par la survenue à la 3 e semaine du traitement d’une pancréatite aiguë, classée stade C sur le scanner abdominal, sans signes de gravité biologique. La patiente a été mise sous mesures symptomatiques avec arrêt immédiat de la 6-mercaptopurine. L’évolution a été marquée par une bonne amélioration clinique. Conclusion : La fréquence de la pancréatite aiguë au cours des maladies inflammatoires chroniques intestinales reste variable. L’origine médicamenteuse notamment la 6-mercaptopurine et l’azathioprine, en est la cause principale. La survenue de cette complication impose l’arrêt définitif de ce traitement et son remplacement par une autre alternative thérapeutique.
La méthode Bayésienne pour aider à évaluer l’efficacité des thérapies personnalisées
Authors: Donatini Bruno 
Published: February 2022

Une analyse de la littérature sur l’approche bayésienne en médecine puis quelques illustrations mathématiques simples et concrètes permettent de constater son usage quotidien, soit dans la prise de décision en urgence (dans les intoxications aiguës), dans la détermination de la fiabilité des tests de dépistage, dans l’évaluation de la causalité des effets indésirables ou encore dans le calcul de la fiabilité des tests cliniques orthopédiques. Sous certaines réserves, il est possible d’étendre son utilisation vers l’évaluation de l’efficacité de thérapies complémentaires qui se prêtent difficilement à la randomisation et à l’approche comparative classique. Grâce à la collecte de plusieurs cas informatifs, il est possible de générer des alertes convaincantes sur l’intérêt de thérapies complémentaires. En effet, sous réserve d’un diagnostic précis, d’un critère d’évaluation de référence, de l’absence de phénomène interférant, d’un suivi suffisant et d’un « dechallenge » et d’un « rechallenge » positifs, la probabilité bayésienne posttest dépasse 99,99 % ce qui permet de qualifier l’efficacité de « probable ». Un groupe de cas informatifs (10 à 20) devrait alors conduire à des essais comparatifs ciblés et peu coûteux pour confirmer la convergence des méthodes mathématiques bayésiennes et fréquentistes et surtout la validité des premiers résultats. Afin de proposer une médecine plus personnalisée (donc plus efficace, moins dangereuse et moins coûteuse) et d’intégrer les thérapies complémentaires de plus en plus plébiscitées et utilisées par nos concitoyens, il est nécessaire de développer des évaluations qui intègrent l’histoire personnelle des patients (approche bayésienne) dans le respect des données actuelles de la science (approche fréquentiste).
Une nouvelle lecture de la Psyché : champ vacant pour thérapies suppléantes
Authors: Courty Daniel 
Published: February 2022

Sur la base d’une épistémologie de la Psychologie, nous cherchons ici à relever les invariants essentiels du « psychisme » habituellement si mal compris dans sa nature propre, en montrant qu’il n’est pas soluble dans l’explication neurobiologique ou physicaliste. Les conséquences en Médecine sont évoquées, en particulier quant au statut des thérapies suppléantes qui semblent mieux le prendre en compte.
Hybridation des inconscients dans l’inter-transe d’une séance d’hypnose
Authors: Midol Nancy 
Published: February 2022

Après l’introduction, l’article décrit une séance d’hypnose (qui s’est transformée en « happening »), puis la soumet à la méthodologie de « l’entretien d’explicitation » définie par Pierre Vermersch. Cette méthode permet, étape par étape, d’analyser les interactions qui ont émergé dans l’espace transactionnel des deux présences. La situation d’hypnose qui convoque des états de transes est particulièrement intéressante pour évaluer ce qui se co-construit dans cette communication. Le résultat fait apparaître comment des connaissances implicites ont nourri le « tiers inclus », (le contenu et le sens de ce qui est partagé par le thérapeute et son client). Dans cette séance, apparaissent des niveaux inconscients et imaginaires conformes à l’inconscient collectif occidental, mais aussi à d’autres inconscients ethniquement étrangers, faisant émerger le phénomène d’hybridation. Ce phénomène est interprété comme le reflet et l’effet de la mondialisation qui entraîne les acteurs à intégrer des logiques autres et paradoxales. Cela questionne directement la médecine intégrative ou complémentaire qui choisit d’intégrer d’autres médecines et à ce titre, se trouve confrontée à la validation de médecines issues d’ancestrales traditions aux origines chamaniques. Trois questions en émergent : La science nouvelle peut-elle s’aventurer au cœur des interactions transactionnelles des états de transes partagées ? Serait-il possible de concevoir l’hypnose, non comme une technique objectivable, mais comme un rapport d’inter-transe dans une situation particulière de soin ? Serait-il possible de s’intéresser de façon scientifique aux compétences de guérison de certains mécanismes spirituels, notamment celui de la réversion ?
A Comparative Analysis of Clinical and Imaging Features of Aquaporin 4 (AQP4) Antibody Positive, Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Positive and Double Seronegative Subtypes of Neuro Myelitis Optica Spectrum Disorder (NMOSD)
Authors: Gupta Salil , Rehani Varun , Dhull Pawan , Somasekharan Manoj , Sreen Amit 
Published: February 2022

Objectives:
Study was conducted with aim of comparing subtypes types of NMOSD based on serology.

Methods:
In this retrospective study, patients ≥18 years were included satisfying IPND 2015 criteria. Three groups were created based on seropositivity for AQP4 antibody, MOG antibody or double seronegative. Demographic, clinical and imaging were compared using regression analysis.

Results:
Forty-six patients, 28 (60.9%) AQP4+, 11 (23.9%) MOG + and remaining 7 (15.2%) double seronegative were included. Thirty-seven patients (80.4%) had presenting symptoms localized to optic nerve and/or cord [AQP4 + 22 (78.5%), MOG + 9 (81.8%) and double seronegative 6 (85.7%)]. Presentation with bilateral optic neuritis was more common in AQP4- patients. Twenty (86.8%) out of the 23 patients who had relapsing disease localized to optic nerve and/or spinal cord [AQP4 + 13/14 (92.8%), MOG + 3/5 (60%) and double seronegative 4/4 (100%)]. Relapses were more common in AQP4+ (77% vs 12% vs10%). In AQP4 negative group disability (EDSS 4.2 vs 3.3) and progression index was relatively less (1.6 vs 1.1). CSF pleocytosis (38.8% vs 17.9%) and raised proteins (66.6% vs 32.1%) were also more common. Optic nerve MRI (>50% optic nerve and chiasma involvement) was more commonly abnormal in AQP4 negative (52.9% vs 31.2%). Regression analysis revealed females to be significantly higher in AQP4 positive NMOSD (89.3%) when compared to MOG positive (36.4%) and double seronegative (42.9%).

Conclusion:
Gender was the only significant difference between the three groups. There was trend towards greater disability and more relapses in AQP4 + groups.
Communication Concerns During Corona Virus Disease-2019 Pandemic Duties
Authors: Jahagirdar Shriharsh Shrinath , Vaidya Pratibha Milind , Faria Yashvi P. , Jadhav Jyoti A. , Bharmal Ramesh N. 
Published: February 2022

Background:
Communication is cornerstone of patients' care for all health professionals. Coronavirus disease 2019 (COVID-19) fetched unique challenges to the art of communication.

Objectives:
The aim of the study was to understand the challenges of communication and to find effective ways of communication with patients and others while having worn personal protective equipment (PPE) by the healthcare workers during COVID-19 duties.

Study Design:
A cross-sectional, online-survey study design was chosen for the research.

Methods:
An online questionnaire-based survey was conducted to understand challenges in communicating with patients and significant others while wearing a PPE. The questionnaire was shared as a Google Form link to 150 postgraduate (PG) students under Maharashtra University of Health Sciences.

Results:
Responses were received from 50 PG students. The difficulty in communication while having worn PPE was experienced by PG students (n = 49, 98%) in older adult age group as compared to other age groups. PG had physical concerns in the form of perceived difficulty in breathing (n = 40, 80%), shortness of breath (n = 26, 52%), and fatigue (n = 40, 80%) that interfered with their communication while working in COVID care wards. Understanding facial expression, verbal expression, gestures, comprehension, history taking, performing assessments (cognitive), recognizing staff, and building rapport were the most challenging aspects of communication for front-liners while having worn PPE. Proxy communication strategies such as sign language (n = 21, 42%), speaking loudly (n = 44, 88%), and demonstrations (n = 4, 8%) were used to overcome challenges in communication while working in COVID-19 wards.

Conclusion:
We found that wearing PPE as a part of a physical (nonhuman) environment hindered effective communication with patients and significant others. Perceiving facial expression, verbal expression, gestures, comprehension, history taking, performing assessments (cognitive), recognizing staff, and building rapport are the most challenging aspects of communication for front-liners while having worn PPE.
Profile of Pediatric Tumors
Authors: Sofi Mushtaq Ahmad , Lone Mohammad Maqbool , Fatima Kaneez , Andleeb Asifa , Fir Afroz , Khan Nazir Ahmad , Najmi Arshad Manzoor , Dar Nazir Ahmad , Nasreen Shahida 
Published: February 2022

Objective:
The objective of this study was to find the profile of childhood cancers in the Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, India, from 2010 to 2019.

Materials and Methods:
It was a retrospective study where medical records of children with cancer that was registered in regional cancer center SKIMS, Srinagar, from January 2010 to December 2019, aged 0–14 years diagnosed using histological or cytological examinations were reviewed to gather data on the prevalence and pattern of tumors according to age, sex, and rural and urban distribution.

Results:
There were 38,962 new confirmed cases registered in the regional cancer center at SKIMS, Srinagar, during these 10 years. Among which 1036 were below 15 years of age. An average of 103 cases attended per year. Overall pediatric tumors were 2.66% of total cancers. The frequency of cancer was found to be higher among boys (57.9%) than girls (42.1%) with a ratio of 1.37:1. The majority of the children were from rural areas (84.9%) compared to (15.1%) from urban areas. The results showed that leukemia (36.6%), lymphoma (19.8%), and bone tumors (9.3%) were the commonly found childhood cancers among the children attended at SKIMS, Srinagar, during these 10 years. Other less commonly found tumors were central nervous system tumors (6.7%), Wilms' tumor (4.1%), retinoblastoma (3.7%), and cancer of unknown primary with secondaries (1.5%).

Conclusions:
Leukemia, lymphoma, and bone tumors were the most common malignancies reported in the children treated at our cancer center.
Methanol Stem Bark Extract of Ficus platyphylla Protects Against Carbon Tetrachloride-Induced Liver Damage in Wistar Rats
Authors: Ugwah-Oguejiofor C.J. , Ibrahim S.G. , Mshelia H.E. , Mohammed U. , Adebis I.M. 
Published: February 2022

Ficus platyphylla (Gutta percha tree) is used in Nigerian traditional medicine for treating pain and psychosis. This study evaluated the protective effect of methanol stem bark extract of Ficus platyhylla (MEFP) against carbon tetrachloride (CCl4)-induced liver injury in Wistar rats. Rats were allotted into six groups namely normal control, negative control, standard drug (silymarin) and extract treated (100, 200 and 400 mg/kg p.o. respectively) groups. Treatment was administered for 7 days. Animals in groups II-VI received a single dose of CCl4 (1:1) p.o. in olive oil at 1.5 ml/kg body weight after last treatment. Experimental rats were sacrificed after 24 hours of CCl4 administration and blood samples collected for determination of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Supernatant of liver homogenate was used to determine activities of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx). Results indicate increased activities (p < 0.05) in CAT, SOD and GPx in samples of MEFP treated rats while levels of ALT and AST in serum samples of treated groups differ significantly (p<0.05) when compared with negative control group (Group III). Treatment with methanol stem bark extract of Ficus platyphylla may have offered protection against CCl4 induced liver damage in experimental rats.
Suicidio y manifestaciones psicológicas frente al covid-19 en adolescentes de Camotán
Authors: Mejia Betancourth Kateryn Morelia 
Published: February 2022

OBJETIVO: determinar la intencionalidad suicida durante pandemia COVID-19 en adolescentes de secundaria del municipio de Camotán MÉTODO: se realizó un estudio descriptivo transversal en 80 adolescentes del nivel secundario del municipio de Camotán. RESULTADOS: se determinó que el 35.1% (N=28) de los adolescentes pertenecen a la edad de 14 años, los factores que provocan la ideación suicida están los de mayor prevalencia de tipo personal como lo es la depresión, estrés y ansiedad con un 40%, (N=32) los datos obtenidos a través de la escala de ideación suicida muestra que la población de estudio presenta débil deseo de vivir con un total de 67.5 %, (N=54). CONCLUSION: el suicidio es un fenómeno multifactorial y un problema de mucha relevancia de salud pública por lo cual el elemento frágil como consecuencia para la ideación suicida está el temor a fallecer por COVID-19 obteniendo un total de 38.8 % (N=31) de las respuestas de los adolescentes de secundaria del municipio de Camotán, Chiquimula.
Surgical research: Exploring our history — navigating the future
Authors: Nadeem Ahmed Siddiqui  , Muhammad Shahzad Shamim  , Syed Ather Enam  
Published: February 2022

In the fifteenth century, trained individuals called' barber surgeons' mastered the art of handling sharp instruments and performing basic surgical procedures. They even founded a 'United Company of Barber Surgeons' in 1540.1 Besides shaving and haircutting, they were trained to perform dental extractions and a few surgical procedures. Later in 1745, qualified doctors and surgeons came together and founded 'Company of Surgeons' in the UK, which later became the Royal College of Surgeons inLondon.2 This progression from anecdotal experiences of the guild of barbers to a formal society that helped the implementation of scientifically reasoned decisions by Royal College Surgeons was only possible because surgeons were able to appreciate the value of the evidence and incorporate it into their practices.
Continuous...
Perioperative registries in resource-limited settings: The way forward for Pakistan
Authors: Waqar Usama , Shaheer Ahmed  , Ayesha Nasir Hameed  , Namrah Aziz  , Hina Inam  
Published: February 2022

Capable of improving surgical quality, perioperative registries can allow performance benchmarking, reliable reporting and the development of risk-prediction models. Well established in high-income countries, perioperative registries remain limited in lower- and middle-income countries due to several challenges. First, ensuring comprehensive data entry forums to power the registries is difficult because of limited electronic medical records requiring sustained efforts to develop and integrate theseinto practice. Second, lack of adequate expertise and resources to develop and maintain registry software necessitates the involvement of software developers and information technology personnel. Third, case ascertainment and item completion are challenging secondary to poor-quality medical records and high lossto- follow-up rates, requiring telemedicine initiatives as anadjunct to existing care for the assessment of postdischarge outcomes.
Continuous...
Peran Orang Tua Dalam Menanamkan Nilai-Nilai Agama Islam pada Anak dI SDN Sukamahi 02
Authors: Hasyifa Nurtupia 
Published: February 2022

The role of parents has an important position in the formation of children, such as character, attitude, knowledge, reasoning and so on. The family as a place of socialization and having a position of religious values ​​is the basis for children to behave in life in the future. The focus of this research is how the role of parents in instilling the values ​​of religious education in children, how the role of parents in instilling religious values ​​in children, and the role of parents in instilling moral values ​​in children at SDN Sukamahi 02. The method used used is a qualitative research with the type of research is a descriptive study. Data collection techniques used are observation, interviews, and documentation. Based on the results of the study, in instilling the values ​​of Islamic religious education in instilling educational values ​​in children, in this case parents at SDN Sukamahi 02 have played an important role in instilling religious values ​​in their children through approaches and interactions with children. In addition, parents have considered it important in instilling religious values ​​in children, because religion is the foundation in life, so that children become pious and pious. And the way parents instill religious values ​​in children is by introducing the existence of God to children, being a good example and making direct implementations with a good attitude to children. In instilling the values ​​of worship, parents at SDN Sukamahi 02 motivate, direct, teach and provide examples of the importance of worship in religious life, both in teaching how to pray, performing ablution, supervising children when praying so that they are accustomed since childhood to worship Allah. S.W.T. As for instilling moral values, parents at SDN Sukamahi 02 are to set a good example or example to their children and teach children to get used to living a good moral life.
Keywords: The Role of Parents, Instilling Religious Values
Implementasi Pendidikan Karakter di Pondok Pesantren Darusalam Tasikmalaya
Authors: Julaeha Siti 
Published: February 2022

Islamic boarding schools are one of the oldest Islamic educational institutions in Indonesia, the role of Islamic boarding schools in shaping the character of their students always exists, as seen from the graduations produced by Islamic boarding schools, character education at the Khalaf Darussalam Islamic boarding school, Tasik and explaining the values ​​forming the character of the students and strategies implementation of character education in the Darussalam Islamic boarding school, Tasik. The results of this mini research conclude that Islamic boarding schools are educational institutions that implement character education integrally in the entire education and learning process in Islamic boarding schools. Because of that, a typical pesantren culture was formed which distinguishes it from the education system outside the pesantren. The values ​​developed by the pesantren in shaping the character of its students include five values: namely independence, sincerity, awareness, simplicity, and brotherhood based on the spirit of religion. In addition, the Islamic boarding school Khalaf Darussalam Tasik generally develops the motto made by Pondok Modern Gontor, because Darussalam Tasik is part of the Gontor Islamic Boarding School branch, namely: being in good health, knowledgeable, and free-thinking. The values ​​forming the character of the khalaf pesantren are then implemented both in the learning process, the formation of the pesantren culture, co-curricular activities, and extracurricular activities.
Keywords: Islamic boarding school, implementation of character education, character values
Analisis SWOT Faktor Penyebab Penurunan Jumlah Peserta Didik Lembaga PAUD di Kabupaten Bogor
Authors: Kusumawati Erna 
Published: February 2022

This study aims to analyze the SWOT factors that cause the decline in students in Early Childhood Education (PAUD). This research is a case study in one TKQ in Bogor Regency using a qualitative descriptive method through interviews and field observations. The results showed that the factors that caused the decrease in students in one PAUD institution were starting with the identification of strengths, weaknesses, opportunities, and challenges. TKQ Education has not prioritized strengths and minimized weaknesses and has not been able to take advantage of opportunities to be better. TKQ Education has not been able to maintain several quality components such as coordination, cooperation, consumers, commitment and involvement of all elements of the school and community to improve the quality of TKQ Education together.
Keywords: SWOT analysis, causal factors, reduced students
Study Of Tourism Travel Patterns In Bantul Regency, Yogyakarta Post Pandemic Covid-19
Authors: Rahmadi Hari , Nugroho Setyo Prasiyono 
Published: February 2022

This study aims to create a pattern of tourist travel in Yogyakarta, especially in Bantul Regency with the approach of Complex Neighborhood, Destination Region Loop, and Chaining Loop. The method used in the preparation of this travel pattern is through a qualitative approach by using primary data and secondary data. The qualitative data (narrative) is then described, grouped, analyzed, and mapped to be made into an image/pattern that can describe a travel pattern. Primary data was obtained through surveys, observations, and interviews with tourism stakeholders. Meanwhile, secondary data was obtained from databases and statistical data available at the Bantul Tourism Office and Yogyakarta Special Region Tourism Office, final reports and the results of relevant activities/research, as well as various other academic references. The results showed that the most visited tourist destinations were Baru Beach, Goa Cemara Beach, Pandansari Beach, Warung Ndeso, Krebet Tourist Village, Tourist Village, Kasongan, Natadamar Mangunan Coffee Shop, Seribu Batu, Glam Camp Bukit Lintang Sewu Mangunan, Tourist Village Banyusumurup
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