bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beam emittance growth due to the strong space-charge field at low energy of a high-intensity ion linac and its mitigation using an octupole magnetic field
Authors: Chimura Motoki , Harada Hiroyuki , Kinsho Michikazu 
Published: May 2022

Abstract
In the low-energy region of a high-intensity ion linac, a strong space-charge field causes a rapid beam emittance growth over a short distance of only a few meters. The beam emittance growth leads to beam loss and machine activation, raising a serious issue for regular maintenance of the accelerator component and beam power ramp-up. We studied the mechanism of beam emittance growth due to the space-charge field based on three-dimensional particle-tracking simulation and theoretical considerations. Numerical simulations of the high-intensity H− (negative hydrogen) linac at the Japan Proton Accelerator Research Complex shows that the nonlinear terms in the space-charge field directly cause beam emittance growth and beam halo formation. We also propose a method to mitigate the beam emittance growth by using an octupole magnetic field, which arises as one of the nonlinear terms in the space-charge field. By applying this method in the simulation we have succeeded in mitigating the beam emittance growth.
Toward diagnosing neutrino non-unitarity through CP phase correlations
Authors: Minakata Hisakazu 
Published: May 2022

Abstract
We discuss correlations between the neutrino-mass-embedded Standard Model CP phase δ and the phases that originate from new physics which cause neutrino-sector unitarity violation (UV) at low energies. This study aims to provide one of the building blocks for machinery to diagnose non-unitarity, our ultimate goal. We extend the perturbation theory of neutrino oscillation in matter proposed by Denton et al. (DMP) to include the UV effect expressed by the α parametrization. By analyzing the DMP-UV perturbation theory to first order, we are able to draw a complete picture of the δ–UV phase correlations in the whole kinematical region covered by terrestrial neutrino experiments. Two regions exist with characteristically different patterns of the correlations: (i) the chiral-type $[e^{- i \delta } \alpha _{\mu e}, \, e^{ - i \delta } \alpha _{\tau e}, \, \alpha _{\tau \mu }]$ (Particle Data Group convention) correlation in the entire high-energy region $\vert \rho E \vert \gtrsim 6 \, (\text{g/cm}^3)$ GeV, and (ii) (blobs of the α parameters)–e±iδ correlation anywhere else. Some relevant aspects for the measurement of the UV parameters, such as the necessity of determining all the αβγ elements at once, are also pointed out. Subject Index: B52, B54
Pathways for assessing interdisciplinarity: A systematic review
Authors: Laursen Bethany K , Motzer Nicole , Anderson Kelly J 
Published: May 2022

AbstractIn many sectors and in many respects, interdisciplinarity has made progress in recent decades, but less so when it comes to evaluating interdisciplinary work. Challenges remain, especially regarding what counts as ‘good’ interdisciplinarity. While previous reviews describe broad trends contributing to these challenges, high-level observations are less suited to: (1) pinpointing underlying sources of persistent evaluative issues, (2) capturing less frequent counterexamples and emerging trends, and (3) providing practical guidance for moving the field forward. This article presents a novel approach for excavating and analyzing assessment designs within and across a wide range of published studies. It is the first study to structure its review of interdisciplinary evaluation around the basics of evaluation theory, creating a simplified model of assessment design choices called an assessment pathway. It further stands alone as an extensive systematic review of the interdisciplinary literature uniquely placed within the context of evaluation, encompassing 20 years, 142 studies, 1,006 assessment pathways, and 19,114 data points. Results show that while interdisciplinary assessments to date excel at variation, only 12% of identified pathways contain the minimum elements required to reach an evaluative judgment. Increased attention to evaluation theory can catalyze progress and provide structure and shared language to a highly varied domain. Readers can visually explore the full dataset online and download it from Harvard’s Dataverse.
Responsible Hedge Funds
Authors: Liang Hao , Sun Lin , Teo Melvyn 
Published: May 2022

Abstract
Hedge funds that endorse the United Nations Principles for Responsible Investment (PRI) underperform other hedge funds after adjusting for risk but attract greater investor flows, accumulate more assets, and harvest greater fee revenues. Consistent with an agency explanation, the underperformance is driven by PRI signatories with low environmental, social, and governance (ESG) exposures and is greater for hedge funds with poor incentive alignment. To address endogeneity, we exploit regulatory reforms that enhance stewardship and show that the ESG exposure and relative performance of signatory funds improve post reforms. Our findings suggest that some hedge funds endorse responsible investment to pander to investor preferences.
Occupational exposure in automobile repair workshops: toxicological effects of contaminated soil in Wistar rats
Authors: Taiwo Odunayo Anthonia , Dosumu Oluwatosin Adebisi , Akomolafe Omoyemi Victoria , Oni Eniola Oluwayemisi , Adefuye Adefemi Oluwasegun , Shofunde Abiodun Abayomi , Samuel Omolola Mary , Ojo Oluwafemi Adeleke 
Published: May 2022

Abstract

Background
Automobile repair workshops contribute immensely to the generation of soil and water contamination. This study was conducted to compare the soil microbial load, heavy metals, and consequent toxicological effects, in three (3) automobile mechanic sites.

Method
Soil samples were randomly collected from 3 different auto mechanic workshop in Abeokuta town of Ogun-State, Nigeria. Bacterial and fungal counts were done via standard procedures. High-performance liquid chromatography was employed for the aflatoxin quantification. Also, 24 Wistar rats were divided into 4 groups (n = 6), group 1—Control animals: orally administered distilled water, Group 2—administered soil sample solution from Ita Oshin mechanic site (I M), Group 3—administered soil sample solution from Ajebo mechanic site (A M), while Group 4—administered soil sample solution from Laderin mechanic site (L M), for two (2) weeks. Conventional methods were used to determine some physical and biochemical parameters in the rat’s serum and tissues.

Results
Eight bacterial and fungal genera were identified from the soil samples with Bacillus subtilis and Aspergillus niger occurring most frequently. The levels of heavy metals (lead, zinc, chromium, and cadmium) analyzed were higher than the WHO permissible heavy metal limits in all samples. The activity of liver function enzymes ALP, AST, and ALT was significantly increased in the serum of animals exposed to the 3 soil solution samples when compared with the control group, with the highest recorded at Site II.

Conclusion
High level of heavy metals and aflatoxins could predispose to several health-related hazards when humans are exposed to contaminated soil solutions around and within automobile mechanic areas.
Intraocular Peak Pressure in Patients Under Treatment With Fixed Combination of Bimatoprost/Timolol/Brimonidine Once Daily Versus Twice Daily
Authors: Susanna Bianca N. , Susanna Carolina N. , Susanna Fernanda N. , Mota Rodrigo T. , Barbosa Gabriel C.S. , Lima Vagner L. , Susanna Remo 
Published: May 2022

Précis:
We investigate the efficacy of triple-fixed-combination of bimatoprost/brimonidine/timolol once and twice a day, demonstrating higher intraocular pressure reduction with once-a-day use, and discuss possible implications based on previous literature.

Purpose:
The purpose of this study was to compare the efficacy of a fixed combination bimatoprost-timolol-brimonidine (Triplenex) instilled once-daily with twice-daily in primary open angle glaucoma.

Patients and Methods:
A randomized clinical trial at a public eye care institution. Thirty patients with primary open angle glaucoma were followed up for 3 months. The right and left eyes of these patients were randomly assigned to once-daily (10:00 pm) or twice-daily (10:00 am; 10:00 pm) regimens of fixed combination bimatoprost-timolol-brimonidine. Intraocular pressure peaks were obtained with the water drinking test before the introduction of this medication (basal WDT0), 1 month (WDT1), 2 months (WDT2), and 3 months (WDT3) after starting the use of the fixed combination of bimatoprost/timolol/brimonidine (Triplenex). Variation from peak intraocular pressure at WDT3 to peak at WDT0 was compared within groups of 2 versus once-daily regimen.

Results:
Sixty eyes of 30 patients (age: 70.67±9.70 y) were included in this study. Baseline clinical characteristics were comparable between groups. The mean reduction in peak intraocular pressure from WDT0 to WDT3 was 6.1±6.1 mm Hg (30.5%) in the eyes receiving 1 drop per day and 4.3±5.7 mm Hg (21.5%) in the eyes receiving 2 drops per day (P=0.023). Mean reduction in peak intraocular pressure considering all WDT was also higher in the group with once-a-day treatment (5.90±6.03 vs. 4.46±4.28 mm Hg, P=0.006).

Conclusion:
Fixed combination of bimatoprost 0.01%, brimonidine tartrate 0.15%, and timolol maleate 0.5% once-a-day is more effective in reducing peak intraocular pressure as measured by the WDT than twice-a-day dosing.
2021 Taiwan Stroke Society Guidelines of blood pressure control for ischemic stroke prevention
Authors: Chi Nai-Fang , Chung Chih-Ping , Cheng Hao-Ming , Liu Chi-Hung , Lin Chun-Jen , Hsu Li-Chi , Tang Sung-Chun , Lee Jiunn-Tay , Po Helen L. , Jeng Jiann-Shing , Wang Tzung-Dau , Lee I-Hui ,   Taiwan Stroke Society Guideline Consensus Group
Published: May 2022

Background:
Since the publication of the 2015 Taiwan Stroke Society Blood Pressure for Treatment and Prevention of Stroke Guideline (2015 TSS BP Guideline), several new clinical studies have addressed whether a stricter blood pressure (BP) target would be effective for stroke prevention.

Methods:
TSS guideline consensus group provides recommendations on BP targets for stroke prevention based on updated evidences.

Results:
The present guideline covers five topics: (1) diagnosis of hypertension; (2) BP control and primary prevention of ischemic stroke; (3) BP control and secondary prevention of ischemic stroke; (4) BP control and secondary prevention of large artery atherosclerosis ischemic stroke; and (5) BP control and secondary prevention of small vessel occlusion ischemic stroke.

Conclusion:
The BP target for most stroke patients with hypertension is <130/80 mm Hg.
Comparison of a home sleep test with in-laboratory polysomnography in the diagnosis of obstructive sleep apnea syndrome
Authors: Hung Chuan-Jen , Kang Bor-Hwang , Lin Yaoh-Shiang , Su Hsing-Hao 
Published: May 2022

Background:
In-laboratory, polysomnography (PSG) is the gold standard for diagnosing obstructive sleep apnea syndrome (OSAS). However, the long waiting list and sleeping at a hospital make patients hesitate to undergo the examination, thereby delaying diagnosis. During coronavirus disease 2019 (COVID-19) pandemic, sleep labs are almost closed, and the delay is worsening. The home sleep test (HST) enables subjects to be tested at home, a familiar and comfortable environment, without a long waiting list. This study assessed the accuracy of a type III HST in diagnosing OSAS in the Taiwanese population and identified factors affecting the diagnostic accuracy.

Methods:
This retrospective study included 67 patients with clinically suspected OSAS. All patients were allocated to receive both PSG and the HST. The apnea-hypopnea index (AHI) measured through PSG was used as the standard. The sensitivity, specificity, and accuracy of the HST in diagnosing and evaluating the severity of OSAS were analyzed.

Results:
Among the 67 patients, no significant difference was noted in the average AHI values obtained using PSG and the HST (p = 0.103). The AHI obtained from HST was significantly correlated with that obtained from PSG, with the correlation coefficient being 0.779 (p < 0.001). The sensitivity, specificity, and accuracy of the HST in diagnosing OSAS were 94.9%, 62.5%, and 91.0%, respectively, and 80.0%, 74.1%, and 77.6% in diagnosing moderate to severe OSAS. Furthermore, the difference in AHIs measured using the two tests were positively correlated with the severity of sleep apnea.

Conclusion:
The HST used in preliminary screening of patients with suspected OSAS achieved an accuracy of >90%. For patients with moderate to severe OSAS, the accuracy was below 80%. Therefore, for patients who receive an OSAS diagnosis through the HST, arrangement of PSG is recommended for determining the severity of the OSAS and giving proper treatment.
A Multifactorial Analysis of Extracranial Carotid Disease: A Comprehensive Approach to Sonographic Criteria
Authors: Silva Fernanda Costa Sampaio , Aras Júnior Roque 
Published: May 2022

Abstract
The present study brings a pictorial review aimed to discuss the multifactorial interpretation of extracranial carotid atheromatous disease, contemplating not only the degree of stenosis but also the arterial flow patterns, the intima-media thickness and the morphological characteristics of the atheromatous plaque. We merged the recommendations contained in the different reference literature on the topic to give a comprehensive approach to ultrasound criteria for diagnostic carotid examination. We infer that the carotid ultrasound evaluation must include important predictors of cardiovascular risk, which should be written in the ultrasound reports, thus allowing the adequate clinical approach to the disease.
Intraoperative Invasive Blood Pressure Monitoring in Flap-Based Lower Extremity Reconstruction
Authors: Haffner Zoë K. , Dekker Paige K. , Abu El Hawa Areeg A. , Bekeny Jenna C. , Kim Kevin G. , Fan Kenneth L. , Evans Karen K. 
Published: May 2022

BackgroundDespite the lack of clear indications for the use of intra-arterial lines (IALs) for intraoperative hemodynamic monitoring, they are often used in a variety of settings. In this retrospective review of patients undergoing free tissue transfer (FTT) for lower extremity (LE) reconstruction, we sought to (1) identify patient factors associated with IAL placement, (2) compare hemodynamic measurements obtained via IAL versus noninvasive blood pressure (NIBP) monitoring, and (3) investigate whether method of hemodynamic monitoring affected intraoperative administration of blood pressure–altering medications.MethodsPatients undergoing LE FTT from January 2017 through June 2020 were retrospectively reviewed. Patients were pair matched based on flap donor site, sex, and body mass index to identify patient factors associated with IAL placement. Methods previously described by Bland and Altman (Lancet.1986;327:307–310) were used to investigate agreement between IAL and NIBP measurements.ResultsSixty-eight patients were included with 34 patients in the IAL group and 34 in the NIBP group. Older patients (P= 0.03) and those with a higher Charlson Comorbidity Index (P= 0.05) were significantly more likely to have an IAL placed. Agreement analysis demonstrated that mean arterial pressures calculated from IAL readings were as much as 31 points lower or 28 points higher than those from NIBP. Bias calculations with this extent of difference suggest poor correlation between IAL readings and NIBP (R2= 0.3027). There was no significant difference between groups in rate of administration of blood-pressure altering medications.ConclusionsSurgeons should consider the risks and benefits of IAL placement on a case-by-case basis, particularly for patients who are young and healthy. Our findings highlight the need for clearer guidance regarding the use of IAL in patients undergoing LE FTT.
Myofascial Flap Closure Decreases Complications in Complex Surgery of the Craniocervical Junction in Ehlers-Danlos Patients
Authors: Norman Sofya , Chae John K. , Marano Andrew A. , Baaj Ali A. , Greenfield Jeffrey P. , Otterburn David M. 
Published: May 2022

Introduction
Patients with Ehlers-Danlos syndrome (EDS) are at elevated risk for soft tissue complications when undergoing decompression with or without fusion of the craniocervical junction. We have previously shown that muscle flap closure can decrease reoperative rates. This study investigated whether myofascial flap closure improved clinical outcomes after simple or complex surgery of the craniocervical junction in EDS patients specifically.

Methods
We performed a retrospective chart review of EDS patients who had undergone surgery for Chiari malformation at the Weill Cornell Medical Center between 2013 and 2020. Postoperative complications were recorded, including infection, wound dehiscence, seroma, hematoma, hardware removal, cerebrospinal fluid (CSF) leak, reoperation, and pseudomeningocele. Patients were stratified by type of closure and type of surgery. Fisher exact test was used for statistical comparison.

Results
Between 2013 and 2020, 62 EDS patients who had surgery of the cervicocranial junction were reviewed. Of these, 31 patients had complex surgery with myofascial flap closure and 22 had simple surgery with traditional closure. The mean age at the time of surgery was 21.3 years. There were no significant differences in wound complications or reoperation rates between the simple surgery and complex surgery groups. In addition, there were no significant differences in complications between complex surgery with flap closure and simple surgery with traditional closure. Our CSF cutaneous fistula rate was 0%, considerably lower than rates reported in the literature, and, in one case, a patient developed a postoperative pseudomeningocele secondary to a dural leak, but the myofascial flap closure prevented its progression.

Conclusions
Patients with EDS undergoing surgery of the cervicocranial junction may benefit from myofascial flap closure. Flap closure reduced complications after complex surgery of the craniocervical junction to the level of simple surgery. Our CSF leak rate was exceptionally low and only one patient experienced pseudomeningocele. Myofascial flaps are safe to perform in the EDS cohort and prevented CSF cutaneous fistula formation.
Safety of Breast Reconstruction Using Inferiorly Based Dermal Flap for the Ptotic Breast
Authors: Calderon Thais , Skibba Kathryn EH , Hansen Trevor , Amalfi Ashley , Chen Elaina 
Published: May 2022

Introduction
The use of an inferiorly based dermal flap (IBDF) with implant insertion allows for 1-step reconstruction of a ptotic breast after mastectomy. An IBDF allows for secondary protection of the inferior pole and provides a vascularized pocket for implant insertion. Previous literature has demonstrated the use of this surgical approach for optimal patient satisfaction and higher patient-reported outcomes.
For this approach, the dermal flap epidermis is removed before insetting; however, invaginations containing epithelial components may serve as a nidus for infection. There is no study that has compared the safety of an IBDF technique to standard reconstruction. We hypothesize that there is no increase in surgical complications in the IBDF approach versus standard reconstruction.

Methods
This is a single-institution retrospective chart review of all patients who underwent implant-based reconstruction from June 2016 through December 2020. Patients who did not have a permanent implant placed by December 2020 or had delayed reconstruction were excluded. Two cohorts were established: those who underwent immediate reconstruction after mastectomy via IBDF and reconstruction without an IBDF. Patient demographics, use of the IBDF technique, and surgical complications were recorded and compared.

Results
A total of 208 breasts were included: 52 breasts in the IBDF cohort and 156 breasts in the control cohort. There were no statistically significant differences between cohorts, except that the IBDF cohort has a significantly higher body mass index (mean = 30.9 vs 26.5, P ≤ .001).
There was no statistically significant difference in the rate of complications between the IBDF and control groups, including seroma (5.8% vs 3.8%), hematoma (3.8% vs 0.6%), wound dehiscence (0.0% vs. 1.9%), mastectomy flap necrosis (11.5% vs 6.4%), breast infection (5.8% vs 7.1%), implant salvage (0.0% vs 5.8%), and implant loss (5.8% vs. 5.8%), respectively.

Conclusions
Using an IBDF to reconstruct a ptotic breast immediately after mastectomy has a similar risk profile to an immediate standard breast reconstruction. This technique has resulted in optimal patient satisfaction scores and allows for a “one-stop reconstruction” of ptotic breasts that normally would undergo sequential revisions. In conclusion, immediate implant-based reconstruction of a ptotic breast after mastectomy using a IBDF can be performed safely.
Disparities in Access to Postmastectomy Breast Reconstruction: Does Living in a Specific ZIP Code Determine the Patient’s Reconstructive Journey?
Authors: Moroni Elizabeth A. , Bustos Samyd S. , Mehta Meeti , Munoz-Valencia Alejandro , Douglas Nerone K. O. , Bustos Valeria P. , Evans Steven , Diego Emilia J. , De La Cruz Carolyn 
Published: May 2022

Background
Postmastectomy breast reconstruction (BR) has been shown to provide long-term quality of life and psychosocial benefits. Despite the policies initiated to improve access to BR, its delivery continues to be inequitable, suggesting that barriers to access have not been fully identified and/or addressed. The purpose of this study was to assess the influence of geographic location, socioeconomic status, and race in access to immediate BR (IBR).

Methods
An institutional review board–approved observational study was conducted. All patients who underwent breast cancer surgery from 2014 to 2019 were queried from our institutional Breast Cancer Registry. A geographical analysis was conducted using demographic characteristics and patient’s ZIP codes. Euclidean distance from patient home ZIP code to UPMC Magee Women's Hospital was calculated, and χ2, Student t test, Mann-Whitney, and Kruskal-Wallis tests was used to evaluate differences between groups, as appropriate. Statistical significance was set at P < 0.05.

Results
Overall, 5835 patients underwent breast cancer surgery. A total of 56.7% underwent lumpectomy or segmental mastectomy, and 43.3% underwent modified, total, or radical mastectomy. From the latter group, 33.5% patients pursued BR at the time of mastectomy: 28.6% autologous, 48.1% implant-based, 19.4% a combination of autologous and implant-based, and 3.9% unspecified reconstruction. Rates of IBR varied among races: White or European (34.1%), Black or African American (27.7%), and other races (17.8%), P = 0.022. However, no difference was found between type of BR among races (P = 0.38). Moreover, patients who underwent IBR were significantly younger than those who did not pursue reconstruction (P < 0.0001). Patients who underwent reconstruction resided in ZIP codes that had approximately US $2000 more annual income, a higher percentage of White population (8% vs 11% non-White) and lower percentage of Black or African American population (1.8% vs 2.9%) than the patients who did not undergo reconstruction.

Conclusions
While the use of postmastectomy BR has been steadily rising in the United States, racial and socioeconomic status disparities persist. Further efforts are needed to reduce this gap and expand the benefits of IBR to the entire population without distinction.