bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kidney‐sparing surgery for distal high‐risk ureteral carcinoma: Clinical efficacy and preliminary experiences in 22 patients
Authors: Jiang Yu , Peng Yueqiang , Ding Siwei , Zheng Yongbo , He Yunfeng , Liu Jiayu 
Published: December 2022

AbstractBackgroundSeveral groups proved kidney‐sparing surgery (KSS) had equivalent oncological outcomes compared with radical nephroureterectomy (RNU) for the low‐risk upper urinary tract urothelial carcinoma (UTUC) patients. Whereas, the clinical efficacy of KSS for high‐risk UTUC, especially for distal high‐risk ureteral carcinoma, remains unclear.ObjectiveTo evaluate the feasibility of KSS for patients with distal high‐risk ureter cancer.Materials and methodsOur study included 22 patients who diagnose the distal high‐risk ureter cancer and underwent KSS between May 2012 and July 2021 in the First Affiliated Hospital of Chongqing Medical University. Overall survival (OS), confirmed as the primary endpoint of present study, was assessed by a blinded independent review committee (BIRC). The secondary endpoints included the postoperative SF‐36 (the short form 36 health survey questionnaire) score, progression‐free survival (PFS), postoperative complications, and so on.ResultsOverall, 17 (77.3%) and 5 (22.7%) patients underwent segmental ureterectomy (SU) and endoscopic ablation (EA), respectively. By the cut‐off date, the mean OS was 76.3 months (95% Cl: 51.3–101.1 months) and the mean PFS was 47.0 months (95% Cl: 31.1–62.8 months), respectively. And the SF‐36 score in a majority of patients was >300 (90.9%).ConclusionThis is a daring endeavor to explore the clinical efficacy of KSS in distal high‐risk ureter cancer based on the high‐risk UTUC criteria, which shows satisfactory results in the long‐term prognosis and operation‐associated outcomes. However, future randomized or prospective multicenter studies are necessary to validate our conclusions.
Exploring the Flexibility of the Glycopeptide Antibiotic Crosslinking Cascade for Extended Peptide Backbones
Authors: Ho Y. T. Candace , Schittenhelm Ralf B. , Iftime Dumitrita , Stegmann Evi , Tailhades Julien , Cryle Max J. 
Published: December 2022

AbstractThe glycopeptide antibiotics (GPAs) are a clinically approved class of antimicrobial agents that classically function through the inhibition of bacterial cell‐wall biosynthesis by sequestration of the precursor lipid II. The oxidative crosslinking of the core peptide by cytochrome P450 (Oxy) enzymes during GPA biosynthesis is both essential to their function and the source of their synthetic challenge. Thus, understanding the activity and selectivity of these Oxy enzymes is of key importance for the future engineering of this important compound class. Recent reports of GPAs that display an alternative mode of action and a wider range of core peptide structures compared to classic lipid II‐binding GPAs raises the question of the tolerance of Oxy enzymes for larger changes in their peptide substrates. In this work, we explore the ability of Oxy enzymes from the biosynthesis pathways of lipid II‐binding GPAs to accept altered peptide substrates based on a vancomycin template. Our results show that Oxy enzymes are more tolerant of changes at the N terminus of their substrates, whilst C‐terminal extension of the peptide substrates is deleterious to the activity of all Oxy enzymes. Thus, future studies should prioritise the study of Oxy enzymes from atypical GPA biosynthesis pathways bearing C‐terminal peptide extension to increase the substrate scope of these important cyclisation enzymes.
Early aseptic loosening of primary total knee arthroplasty in patients with osteonecrosis of the knee: A case series
Authors: Baek Ji‐Hoon , Lee Su Chan , Ryu Suengryol , Ahn Hye Sun , Nam Chang Hyun 
Published: December 2022

AbstractThe cause of early aseptic loosening in total knee arthroplasty (TKA) is uncertain, although several possibilities could be offered. We report that osteonecrosis of the knee should be considered as a possible cause or contributing etiologic factor for early aseptic loosening following primary TKA.
A case report of H‐syndrome from Baghdad Medical City treated with tocilizumab
Authors: Awadh Nabaa Ihsan , Gorial Faiq I. , Hashim Hashim Talib , Al‐Obaidi Ahmed Dheyaa , Al‐Obaidi Mustafa Najah , AlNoori Ali H. , Aljanabi Wesal K. 
Published: December 2022

AbstractThis case report presents the first H‐syndrome rarity in Iraq, a 12‐year‐old female patient who was attending the Rheumatology out clinic for progressive hands joint deformities. She has a history of a multi‐systemic collection of diseases with various clinical features that include beta thalassemia minor, sensorineural deafness, and celiac disease.
Benzaldehyde‐Promoted (Auto)Photocatalysis under Visible Light: Pitfalls and Opportunities in Photocatalytic H2O2 Production**
Authors: Krivtsov Igor , Vazirani Ashish , Mitoraj Dariusz , Beranek Radim 
Published: December 2022

AbstractSelective photooxidation of aromatic alcohols to corresponding aldehydes is a widely used model reaction for evaluation of performance of heterogeneous photocatalysts. A top example is the photocatalytic production of hydrogen peroxide via reduction of dioxygen with concomitant photooxidation of benzyl alcohol to benzaldehyde. Herein we demonstrate the ability of benzaldehyde to promote the auto‐photocatalytic oxidation of benzyl alcohol and produce large quantities of H2O2 in solvent‐free (no water) or biphasic (with water) systems even under nominally visible (>420 nm cut‐off filter) light irradiation. These results shed critical light on the plethora of research reports on photocatalytic H2O2 production in which benzyl alcohol was employed as electron donor. Since the autocatalytic pathway based on the photocatalytic activity of benzaldehyde formed during photocatalysis under such conditions cannot be neglected, the interpretations of photocatalytic performance are likely contentious and distorted in such reports. The use of benzyl alcohol as a model electron donor in photocatalytic studies should be therefore definitely discouraged. On the other hand, as we found that benzaldehyde‐mediated photocatalysis of H2O2 production proceeds also using alternative electron donors (e. g., ethanol), our results highlight the possible prospects for a more general use of benzaldehyde and other aromatic aldehydes in visible light‐driven photocatalysis.
Fully Tin‐Coated Coinage Metal Ions: A Pincer‐Type Bis‐stannylene Ligand for Exclusive Tetrahedral Complexation
Authors: Krätschmer Frederic , Sun Xiaofei , Gillhuber Sebastian , Kucher Hannes , Franzke Yannick J. , Weigend Florian , Roesky Peter W. 
Published: December 2022

AbstractThe synthesis of a novel bis‐stannylene pincer ligand and its complexation with coinage metals (CuI, AgI and AuI) are described. All coinage metal centres are in tetrahedral coordination environments in the solid state and are exclusively coordinated by four neutral SnII donors. 119Sn NMR provided information about the behaviour in solution. All of the isolated compounds have photoluminescent properties, and these were investigated at low and elevated temperatures. Compared to the free bis‐stannylene ligand, coordination to coinage metals led to an increase in the luminescence intensity. The new compounds were investigated in detail through all‐electron relativistic density functional theory (DFT) calculations.
A novel hybrid deep learning model for aspect based sentiment analysis
Authors: Kuppusamy Mouthami , Selvaraj Anandamurugan 
Published: December 2022

SummaryThe usage of social media, forums, and e‐commerce websites have been widely increased. Feedback from customers has a big impact on the final product. A service provider, merchant, or manufacturer need all the information, even if it is just a comment or a review about a service or a product. So, it is vital to look at input from users, and therefore sentiment analysis has received a lot of interest. Sentiment analysis is a method for identifying and analyzing text in order to determine the features, qualities, and viewpoints of particular user. Extracting user aspects is the main part of this process, and it is used to group the user aspects. In recent years, convolutional neural network (CNN) models have gained popularity in natural language processing. Thus, this research proposes a novel hybrid CNN model by concatenating the bidirectional long short‐term memory and CNN models to process the data sequentially by learning their high‐level features. The concatenated method minimizes the loss of critical information. Benchmark product reviews and hotel review datasets are employed in the experiments, and accuracies of 93.6% for the product review dataset and 92.7% for the hotel review dataset are achieved by the proposed hybrid model when compared to state‐of‐the‐art techniques.
SHM‐PWM technique in a cascaded H‐bridge multilevel inverter with adjustable DC‐link for wide voltage range applications
Authors: Pourdadashnia Amirhossein , Farhadi‐Kangarlu Mohammad , Tousi Behrouz , Sadoughi Milad 
Published: December 2022

SummaryIn this paper, a new method for achieving high‐quality voltage in multilevel inverters is presented. The method is based on the selective harmonic mitigation pulse width modulation (SHM‐PWM) technique applied on a cascaded H‐bridge multilevel inverter (CHBMLI), which employs a variable DC‐link voltage to reduce the amount of the total harmonic distortion (THD) in the output waveform. The variable DC sources in a CHBMLI can increase the modulation index to an acceptable range in the low output voltage values and also increase the number of harmonics to be eliminated in the SHM technique due to increasing the number of voltage levels. In the proposed method, the optimal switching angles are calculated by the particle swarm optimization (PSO) algorithm and the switching angles are stored in lookup tables (LUTs). Implementing the proposed method allows the CHB inverter to improve the performance in producing a high‐quality voltage compared with conventional methods. As an applicable example, a single‐phase CHBMLI, fed by two isolated DC sources, is examined in this paper. The analysis presented in this paper shows a significant improvement in the quality of the output voltage, especially for low output voltage conditions. The simulation and experimental results are presented to confirm the proposed approach.
Copper‐Catalyzed One‐Pot Arylation and Cyclization of Diaryliodonium Salts Derived fromo‐Iodoanilines for Indolo[2,3‐b]indoles Syntheses
Authors: Choi Miseon , Mehra Manish Kumar , Lee Chung Whan 
Published: December 2022

AbstractOne‐pot synthesis of various indolo[2,3‐b]indoles has been accomplished from a copper‐catalyzed transformation of easily accessible 2‐(substituted‐amino)aryl)(mesityl)iodonium salts and indole derivatives. Reaction offers great functional group toleration, providing a series of indolo[2,3‐b]indole derivatives in good yields. Additionally, intramolecular cyclization of 2‐(substituted‐amino)aryl)(mesityl)iodonium salts in the presence of copper‐catalyst provided direct access to benzoxazole derivatives.
Nanofibers as optical sensors for model VOCs dispersed in aqueous phase
Authors: Kaczmarczyk Brian , Kalisz Justyna , Kijeńska‐Gawrońska Ewa , Maksymiuk Krzysztof , Michalska Agata 
Published: December 2022

AbstractNanofibers mats, prepared from poly(vinyl chloride) (PVC) containing dispersed dye Nile red (NR) were applied in a proof of concept study as optical sensors for Volatile Organic Compounds (VOCs) dispersed in an aqueous phase. Benefiting from the solubility of the dye, and in some cases, also of the polymer in model solvents belonging to the group of VOCs, an increase of emission was observed for increasing solvent concentration in the sample. The optical signal formation was observed regardless if only the dye or both dye and PVC were soluble in the tested solvent. In both cases, high sensitivity emission increases for increasing VOCs present in the aqueous phase were observed within the range of concentration of model analytes: from 200 ppm of m‐xylene or from 300 ppm of styrene, to up to ca 1500 ppm. The obtained higher detection limit was lower compared to films of PVC containing the dye due to the lower availability of the material to be dissolved by analyte – solvent. The large surface area of nanofibers was useful in the detection, leading to higher signal changes compared to films.
Effects of Oral Lipid‐Based nutritional supplements on appetite, energy intake, and lipid profile of moderately underweight children
Authors: Zubair Aqsa , Fatima Sadia , Habib Hamid , Nazli Rubina , Shah Inayat , Shah Mohsin 
Published: December 2022

AbstractOral lipid‐based nutritional supplements (LNS) are designed to ensure dietary adequacy and to improve malnourishment in children. Therefore, this study investigated the effects of 4 weeks of LNS on appetite, energy intake, and lipid profile of moderately underweight children (5–10 years old) with BMI‐Z score between −2 and − 3 SDS, recruited in a single‐blind randomized control trial. In addition to the regular dietary intake, fasting blood samples, anthropometric measurements, energy intake, and appetite responses were obtained before and after 4 weeks of LNS (535 kcal) or PLACEBO (92 kcal). After 4 weeks of supplementation mean energy intake (kcal) (p < .001), body weight (kg) (p < .001), BMI (kg/m2) (p < .01), mid‐upper arm circumference (cm) (p < .01), total cholesterol (mg/dl) (p < .01) and fasting glucose (mg/dl) (p < .01) were raised significantly in the LNS group as compared to the PLACEBO group. No significant changes were detected in appetite responses (p > 0.05). In conclusion, LNS increases the overall energy intake, but does not affect the appetite but may induce hyperglycemia and hyperlipidemia.
Womenʼs perspectives on the quality of maternal and newborn care in childbirth during the COVID‐19 pandemic in Latvia: Results from the IMAgiNE EURO study on 40 WHO standards‐based quality measures
Authors: Pumpure Elizabete , Jakovicka Dārta , Mariani Ilaria , Vaska Agnija , Covi Benedetta , Valente Emanuelle Pessa , Jansone‐Šantare Gita , Knoka Anna Regīna , Vilcāne Katrīna Paula , Rezeberga Dace , Lazzerini Marzia ,   the IMAgiNE EURO study group
Published: December 2022

AbstractObjectiveTo investigate women's perspectives on the quality of maternal and newborn care (QMNC) around the time of childbirth during the COVID‐19 pandemic in Latvia, comparing the years 2020 and 2021, among women who went into labor or had a prelabor cesarean.MethodsWomen giving birth in healthcare facilities in Latvia from March 1, 2020, to October 28, 2021, answered an online questionnaire including 40 WHO standards‐based quality measures. Descriptive and multivariate quantile regression analyses were performed to compare QMNC in 2020 and 2021.Results2079 women were included in the analysis: 1860 women who went into labor (group 1) and 219 with prelabor cesarean (group 2). Among group 1, 66.4% (n = 99/149) of women received fundal pressure in an instrumental vaginal birth, 43.5% (n = 810) lacked involvement in choices, 17.4% (n = 317) reported suffering abuse, 32.7% (n = 609) reported inadequate breastfeeding support while 5.2% (n = 96) lack of early breastfeeding. A significant reduction in QMNC due to the COVID‐19 pandemic was reported by 29.5% (n = 219) and 25.0% (n = 270) of respondents in 2020 and 2021, respectively (P = 0.045). Multivariate analyses highlighted a significantly lower QMNC index for 2020 compared with 2021 (P < 0.001).ConclusionThis first study investigating QMNC in Latvia showed significant gaps in QMNC perceived by respondents, with slightly better results in 2021. Appropriate healthcare strategies to improve health care for women and newborns in Latvia are required.ClinicalTrials.gov Identifier:NCT04847336.
Photothermal lipolysis accelerates ECM production via macrophage‐derived ALOX15‐mediated p38 MAPK activation in fibroblasts
Authors: Wu Shan , Wang Caixia , Yao Min , Han Dong , Li Qingfeng 
Published: December 2022

AbstractSkin and subcutaneous tissue tightening is usually treated by noninvasive photothermal treatment for medical esthetics purpose, while the underlying mechanism remains to be elucidated. Here, we hypothesized that adipocyte injury, as a stimulator, may regulate extracellular matrix (ECM) production by increasing ALOX15 in macrophages, which could lead to fibroblast activation. In this study, we show that lipolysis was induced by laser heating (45°C for 15 min) in patients and rats, and adipocyte thermal injury stimulates the ECM production in fibroblasts by ALOX15 that was increased in cocultured macrophages. These phenomena were evidenced by the ALOX15 knockdown. In addition, ALOX15 metabolite 12(S)‐HETE activated p38 MAPK signaling pathway that mediated the production of ECM in fibroblast. In summary, the results of this study demonstrate that the mechanisms of adipose photothermal injury‐induced skin and/or subcutaneous tissue tightening may have clinical relevance for noninvasive or minimally invasive photothermal therapeutics.
Euclidean designs obtained from spherical embedding of coherent configurations
Authors: Wang Aiguo , Zhu Yan 
Published: December 2022

AbstractCoherent configurations are a generalization of association schemes. Motivated by the recent study of Q‐polynomial coherent configurations, in this paper, we study the spherical embedding of a Q‐polynomial coherent configuration into some eigenspace by a primitive idempotent. We present a necessary and sufficient condition when the embedding becomes a Euclidean ‐design (on two concentric spheres) in terms of the Krein numbers for . In addition, we obtain some Euclidean 2‐ or 3‐designs from spherical embedding of coherent configurations including tight relative 4‐ or 5‐designs in binary Hamming schemes and the union of derived designs of a tight 4‐design in Hamming schemes.
Biocompatible formulations based on mycosynthesized iron oxide nanoparticles: Fabrication, characterization, and biological investigation
Authors: Kamal Asif , Saba Malka , Farooq Muhammad 
Published: December 2022

AbstractThe current study was carried out to synthesize iron oxide nanoparticles (IONPs) via green reduction method from a wild mushroom collected from Quaid‐i‐Azam University, Islamabad, Pakistan. The collected fungus was identified as Daedalea sp. based on morphological characteristics. Prepared NPs were produced from iron chloride hexahydrate with fungal filtrate via combustion method. The as prepared NPs were characterized by using different techniques for example, scanning electron microscopy (SEM), X‐ray diffractions (XRD), Fourier transform infrared spectroscopy (FT‐IR), and ultraviolet visible (UV‐Vis) spectroscopy. Morphology and size of the NPs were determined by SEM analysis. XRD study revealed crystalline nature of IONPs. The FT‐IR spectrum exhibited peak at 3390.26 cm−1 stretching that described the strong O–H band of the alcohol associated with mushroom texture. The major IONPs dose (0.75 mg/ml) demonstrated 71% growth inhibition against Aspergillus. Excellent antibacterial activities against Pseudomonas aeruginosa (28 mm), and Klesbsilla pneumonia (28 mm) were represented by the fabricated NPs. Further, highest reducing power (53.22 ± 0.72 µg AAE/mg) was shown by the highest administrated dose (400 µg/ml). Maximum 2,2‐diphenyl‐1‐picrylhydrazyl and trolox antioxidant activity free radical scavenging activities at 400 µg/ml IONPs concentration were noted as 51.29 ± 0.48, and 83.12 ± 0.28 trolox equivalent antioxidant capacity, respectively. In brief, the negligible hemolytic activity against human red blood cells at the highest concentration (400 µg/ml), as well as, moderate antioxidant activities at low concentration suggest the application of the fabricated NPs in environmentally sound viable hygiene production.
Strategy for Accurate Diagnosis by Contrast‐Enhanced Ultrasound of Focal Liver Lesions in Patients Not at High Risk for Hepatocellular Carcinoma
Authors: Xian Meng‐Fei , Li Wei , Lan Wen‐Tong , Zeng Dan , Xie Wen‐Xuan , Lu Ming‐De , Huang Yang , Wang Wei 
Published: December 2022

ObjectiveTo develop an effective strategy for accurate diagnosis of focal liver lesions (FLLs) in patients with non‐high risk for hepatocellular carcinoma (HCC).MethodsFrom January 2012 to December 2015, consecutive patients with non‐high risk for HCC who underwent contrast‐enhanced ultrasound (CEUS) were included in this retrospective double‐reader study. All patients were stratified into 2 different risks (intermediate, low‐risk) groups according to criteria based on clinical characteristics, known as clinical risk stratification criteria. For the intermediate‐risk group, the CEUS criteria for identifying benign lesions and HCCs were constructed based on selected CEUS features. The diagnostic performance of the clinical risk stratification criteria, and CEUS criteria for identifying benign lesions and HCCs was evaluated.ResultsThis study included 348 FLLs in 348 patients. The sensitivity and specificity of the clinical risk stratification criteria for malignancy was 97.8 and 69.8%. Patients were classified as intermediate risk if they were male, or older than 40 years of age, or HBcAb positive, or having positive tumor markers. Otherwise, patients were classified as low risk. Among the 348 patients, 327 were in the intermediate‐risk group and 21 were in the low‐risk group. In the intermediate‐risk group, the CEUS criteria for identifying benign lesions were any of the following features: 1) hyper/isoenhancement in the arterial phase without washout, 2) nonenhancement in all phases, 3) peripheral discontinuous globular enhancement in the arterial phase, 4) centrifugal enhancement or peripheral enhancement followed by no central enhancement, or 5) enhanced septa. The accuracy, sensitivity, and specificity of the CEUS criteria for identifying benign lesions were 94.5, 83.0, and 99.6%, respectively. Arterial phase hyperenhancement followed by mild and late washout (>60 seconds) was more common in HCC patients than in non‐HCC patients (P < .001). Using arterial phase hyperenhancement followed by mild and late washout as the CEUS criteria for identifying HCCs, the sensitivity and specificity were 52.6 and 95.3%, but unfortunately, the positive predictive value was only 82.0%. For the low‐risk group, no further analysis was performed due to the small sample size.ConclusionsInitial clinical risk stratification followed by assessment of certain CEUS features appears to be a promising strategy for the accurate diagnosis of FLLs in patients not at high risk for HCC.