bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMANFAATAN E-COMMERCE DALAM MENINGKATKAN PENJUALAN DENGAN PENDEKATAN SISTEM BERORIENTASI OBJEK PADA D’SHOP
Authors: Aman Mustar 
Published: November 2022

Perkembangan UMKM dari tahun ke tahun dipengaruhi dengan pemanfaatan Teknologi Informasi dan Sistem Informasi. e-commerce merupakan salah satu teknologi yang mendukung perkembangan UMKM dan perdagangan saat ini. D’SHOP merupakan perusahaan yang bergerak dibidang Butik yang menjual berbagai macam baju dan celana dari mulai harga terendah sampai dengan harga tertinggi.Berdasarkan hasil analisa yang dilakukan pada D’SHOP Tangerang, maka peneliti dapat menyimpulkan bahwa Masalah yang terjadi pada Sistem penjualan pada D’SHOP adalah penjualan belum berbasis web atau e-commerce dan sistem pengelolaan data belum terkomputerisasi karena proses pengolahan data selama ini masih konvensional serta media promosi masih menggunakan brosur, spanduk dan kartu nama. Tujuan penelitian untuk mengetahui sistem penjualan dengan menggunakan analisis konseptual dan untuk mengetahui faktor pendukung dan faktor penghambat apa saja pada D’SHOP.Metode penelitian yang digunakan adalah kualitatif deskriptif. Tehnik pengumpulan data dilakukan dengan cara observasi, wawancara dan studi pustaka. Hasil penelitian ini diketahui managemen dapat dilihat pada beberapa proses yaitu membuat perincian harga produk, mengegola data pesanan, karyawan melakukan packing produk sampai melakukan pengiriman produk ke consumenKata Kunci : E-commerce, Perancangan, Penjualan, Objek Oriented
ANALISA & PERANCANGAN SISTEM INFORMASI JURNAL MAHASISWA BERBASIS WEB PADA STIE BISMA LEPISI
Authors: Hernanda Randyka Putra , . Nurasiah 
Published: November 2022

Penelitian dalam skripsi ini dilatar belakangi oleh kegiatan-kegiatan yang berkaitan dengan administrasi maupun manajemen, namun masih sebatas untuk mengetik data mahasiswa baru dan alumni, untuk melakukan arsip manajemen jurnal mahasiswa belum menggunakan program khusus untuk membuat laporan yang berhubungan dengan pengolahan data dan informasi jurnal mahasiswa sehingga mengakibatkan keterlambatan akses informasi bagi mahasiswa, maka diperlukan sistem baru dengan menggunakan program khusus untuk mengolah data yang meliputi data informasi jurnal mahasiswa, dan data laporan sistem informasi jurnal mahasiswa, dengan adanya sistem baru akan mempermudah informasi yang cepat dan akan membantu maupun pimpinan dalam menerima laporan data sistem informasi jurnal mahasiswa pada STIE Bisma Lepisi, sehingga dapat menyajikan informasi kepada pengguna lainnya. Tujuan Penelitian ini adalah mengetahui sistem yang berjalan dalam persiapan jurnal mahasiswa di STIE Bisma Lepisi. Untuk merancang sistem dokumentasi jurnal pada STIE Bisma Lepisi Metode penelitian yang digunakan adalah metode pengumpulan data yaitu studi lapangan, wawancara, studi pustaka dan studi literatur sejenis dan Hasil penelitian ini adalah sistem informasi berbasis web yang dapat menambah efisiensi waktuKata Kunci : Analisa, Sistem, Perancangan, Jurnal, Lepisi, Website, mahasiswa
High density and successful breeding of Turtle doves Streptopelia turtur in Moroccan olive groves
Authors: Squalli Wafae , Wink Michael , Mansouri Ismail , Fadil Fatima , Dakki Mohamed 
Published: November 2022

Background
The turtle dove is a migratory species that has suffered a rapid decline principally across its Northern ranges, despite pronounced conservation measures. Consequently, it has been categorized as ‘Near Threatened’ in Europe. Degradation of breeding habitats and a decrease in food resources are listed as principal causes of this decline. Despite its importance, the productivity of the North African population is widely unknown. Here we present the first estimation of the density of the breeding population and the superior reproductively of Streptopelia turtur arenicola in Morocco and entire North Africa.

Methods
This study was carried out for two seasons 2018–2019 in the Saïss plain, central Morocco. Based on previous data, doves were monitored weekly, from early March to late August, in aquatic ecosystems (two dams and one river) and farmlands (cereals and orchards). The breeding population was censused using the “point-count” method, following a walked transect of 5 km in orchards, 7 km in cereal fields, and 3 km along the river. Equally, nests were searched in natural habitats counting riparian trees, forests, and ornamental trees, and in orchards based on the Common Birds Census (CBC) methodology, in which the singing doves, mating pairs, nesting, and/or feeding behavior were the most monitored signs to discover nests. In orchards, nests were searched line-by-line based on the rows of fruit trees. For each recorded nest, we note the breeding chronology, clutch size and incubation period, success and failure factors, dimensions, and vertical placement on trees. To evaluate the predictors of doves’ occurrence, we noted at each site the presence of cereals, water, human disturbance, presence of nesting trees, and predators.

Results and Discussion
In total, 3,580 turtle doves (22.37 birds/ha), including 240 breeding pairs, were documented. Nesting occurred mainly in olive groves, cereals were used for forage, and aquatic ecosystems for water sources. The nesting period lasted from late April to July (last fledglings). All nests were located on olive trees at a height of 225.30 ± 48.87 cm. The clutch size was 1.98 ± 0.13 (laid eggs/built nests), the incubation period lasted 14.16 ± 1.32 days, and the rearing period lasted 16.54 ± 1.76 days. The breeding success among the 240 monitored nests accounted for 73.84% during the nesting phase and 87.42% during the incubation phase; 71.5%% of nestlings have fledged, which is the highest success rate for turtle doves in Europe and Northwest Africa. Clutches were aborted mostly due to predation from snakes (7.5% of nests, 16.12% of eggs, and 5.63% of chicks), nest desertion (9.16% of nests and 5.37% of eggs), and marginally by the destruction of nests through farming activities. These findings are important for conservation plans, to restore turtle doves’ habitats in Europe, where the species is widely declining.
Chromium Induced Developments of Diseases and their Inhibitions by Cargos
Authors: Mandal Ardhendu Kumar 
Published: November 2022

The exposure of hexavalent chromium (Cr-VI) mainly through the inhalation, skin contact or oral administration by the environmental chromium industrial processes causes the major toxicity-induced health hazardous mortality throughout the world. Though reduced chromium (Cr-III), as an essential micronutrient, is utilized to maintain the normal blood glucose, lipid and protein profiles through the metabolism in the body to activate the action of the hormones such as insulin, the high concentration exposures of Cr-VI and Cr-III cause oxidative stress-induced DNA oxidation and adducts, DNA strand breaks and mutations, DNA-protein cross-links, membrane-lipid peroxidation and reduced/altered antioxidant/immune response activities, leading to cellular damage-related various diseases and the development of malignant cancer.
Applications of different cargos may inhibit Cr-VI or its intermediates-induced cytotoxicity, immunotoxicity, or genotoxicity through chromium-chelating and scavenging free radical reactive species, restoring antioxidant and immune response activities or arresting disease-oriented signal transductions or other pathways at cellular and molecular levels. This review mainly demonstrates the development of various diseases by chromium exposure and their inhibitions by cargos.
Exploration of Residual Confounding in Analyses of Associations of Metformin Use and Outcomes in Adults With Type 2 Diabetes
Authors: Powell Mike , Clark Callahan , Alyakin Anton , Vogelstein Joshua T. , Hart Brian 
Published: November 2022

ImportanceMetformin is often used as a first-line therapy for type 2 diabetes; however, frequent discontinuation with reduced kidney function and increased disease severity indicates that a comparison with any other group (eg, nonusers or insulin users) must address significant residual confounding concerns.ObjectivesTo examine the potential for residual confounding in a commonly used observational study design applied to metformin and to propose a more robust study design for future observational studies of metformin.Design, Setting, and ParticipantsThis retrospective cohort study with a prevalent user design was conducted using an administrative claims database for Medicare Advantage beneficiaries in the US. Participants were categorized into 2 distinct cohorts: 404 458 individuals with type 2 diabetes and 81 791 individuals with prediabetes. Clinical history was observed in 2018, and end points were observed in 2019. Statistical analyses were conducted between May and December 2021.ExposuresPrevalent use (recent prescription and history of use on at least 90 of the preceding 365 days) of metformin or insulin but not both at the start of the observation period.Main Outcomes and MeasuresTotal inpatient admission days in 2019 and total medical spending (excluding prescription drugs) in 2019. Each of these measures was treated as a binary outcome (0 vs &amp;gt;0 inpatient days and top 10% vs bottom 90% of medical spending).ResultsThe study included 404 458 adults with type 2 diabetes (mean [SD] age, 74.5 [7.5] years; 52.7% female). A strong metformin effect estimate was associated with reduced inpatient admissions (odds ratio, 0.60; 95% CI, 0.58-0.62) and reduced medical expenditures (odds ratio, 0.57; 95% CI, 0.55-0.60). However, implementation of additional robust design features (negative control outcomes and a complementary cohort) revealed that the estimated beneficial effect was attributable to residual confounding associated with individuals’ overall health, not metformin itself.Conclusions and RelevanceThese findings suggest that common observational study designs for studies of metformin in a type 2 diabetes population are at risk for consequential residual confounding. By performing 2 additional validation checks, the study design proposed here exposes residual confounding that nullifies the initially favorable claim derived from a common study design.
Inherited Cancer Susceptibility Gene Sequence Variations Among Patients With Appendix Cancer
Authors: Holowatyj Andreana N. , Washington Mary K. , Tavtigian Sean V. , Eng Cathy , Horton Carolyn 
Published: November 2022

ImportanceGermline sequence variations in APC, BMPR1A, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, PTEN, SMAD4, STK11, and TP53 genes are associated with susceptibility to gastrointestinal cancers. As a rare cancer, the evaluation of appendiceal cancer (AC) predisposition has been limited.ObjectiveTo assess the prevalence and spectrum of inherited cancer susceptibility gene sequence variations in patients with AC and the utility of germline genetic testing for this population.Design, Setting, and ParticipantsThis cohort study included patients with AC who underwent germline genetic testing of 14 cancer susceptibility genes performed by a clinical testing laboratory between March 1, 2012, and December 31, 2016. Data were analyzed from March to August 2022. Clinical, individual, and family histories were obtained from clinician-completed test requisition forms. Multigene panel testing was performed by targeted custom capture and sequencing and chromosome rearrangement analysis.Main Outcomes and MeasuresThe main outcomes were germline sequence variation prevalence and spectrum in patients with AC.ResultsAmong the 131 patients with AC in the cohort (90 female [68.7%]), a total of 16 deleterious sequence variations were identified in 15 patients (11.5%). Similarly, when limited to the 74 patients with AC as the first and only primary tumor, a total of 8 patients (10.8%) had at least 1 deleterious sequence variation in a cancer susceptibility gene. Overall, 6 patients (4.6%) had a deleterious sequence variation observed in MUTYH (5 with monoallelic MUTYH and 1 with biallelic MUTYH). All 4 patients with Lynch syndrome (3.1%) had a sequence variation in the MLH1 gene, of whom 3 were aged 50 years or older at AC diagnosis. Five patients (3.8%) had deleterious sequence variations in other cancer predisposition genes (1 with APC [c.3920T&amp;gt;A, p.I1307K], 2 with CHEK2 [c.470T&amp;gt;C, p.I157T], 1 with SMAD4 [c.263 287dup, p.L98IFS*14], and 1 with TP53 [c.524G&amp;gt;A, p.R175H]).Conclusions and RelevanceIn this cohort study, 1 in every 10 patients with AC who underwent testing for hereditary cancer predisposition carried an inherited gene sequence variation associated with cancer susceptibility. Given the high frequency and broad spectrum of germline gene sequence variations, these data suggest that genetic evaluation might be warranted for all patients diagnosed with this rare malignant tumor. A systemic sequencing effort for all patients with AC may also identify cancer vulnerabilities to exploit for therapeutic development in a cancer type for which clinical trials are limited.
Neural adaptive dynamic event‐triggered practical fixed‐time dynamic surface control for non‐strict feedback nonlinear systems
Authors: Li Heng , Zhang Tianping 
Published: November 2022

SummaryIn this article, a dynamic surface practical fixed‐time control scheme is proposed based on dynamic event‐triggered mechanism for a class of non‐strict feedback systems. Dynamic surface control (DSC) technology was introduced to solve computational complexity problems. Dynamic triggering technology is implemented to solve the problem of transmitting data burden. Dynamic triggers have fewer triggers than static triggers. Nonlinear filters are introduced to combine DSC technology with fixed‐time adaptive control technology. Theoretical analysis shows that all signals in the closed‐loop system are bounded at a fixed time. Finally, two numerical simulation examples are given to prove the feasibility of the proposed method.
Hofmeister Effect‐Enhanced Hydration Chemistry of Hydrogel for High‐Efficiency Solar‐Driven Interfacial Desalination
Authors: Zou Hongqi , Meng Xiangtong , Zhao Xin , Qiu Jieshan 
Published: November 2022

AbstractSolar‐driven water evaporation technology holds great potential for mitigating the global water scarcity due to its high energy conversion efficiency. Lowering the vaporization enthalpy of water is key to boost the performance of solar‐driven desalination. Herein, a highly hydratable hydrogel (PMH) network, consisting of modified needle coke as photothermal material and polyvinyl alcohol (PVA) as hydratable matrix, is crafted via simple physical cross‐linking method. When capitalizing on the PMH as evaporator for 3.5 wt% NaCl solution, a high evaporation rate of 3.18 kg m−2 h−1 under one sun illumination is deliver ed, unexpectedly outperforming that in pure water (2.53 kg m−2 h−1). More importantly, the PMH shows a robust desalination durability, thus enabling a self‐cleaning system. Further investigations reveal that the outstanding evaporation performance of PMH in brine roots in its hydrability tuned by chaotropic Cl−, wherein the Cl− can mediate the hydration chemistry of PVA in PMH and suppress related crystallinity, thus contributing to the increased content of intermediate water and the lowered vaporization enthalpy of brine. This work first scrutinizes the Hofmeister effect on the evaporation behavior of PMH evaporator in brine and provides insights for high‐efficiency solar‐driven interfacial desalination.
Smart Contact Lenses for the New Era of IoT: Integrated Biosensors, Circuits, and Human–Machine Interface Systems
Authors: Xiang Shengxin , Wang Yuanwei , Zhang Chi , Zhao Zhiwei , Wang Baoping , Zou Wenjun , Wu Jun 
Published: November 2022

AbstractThe rapid development of the Internet of Things (IoT) technology endows some traditional devices with intelligent functions. Compared with traditional contact lenses used for correcting vision or beautifying the eyes, smart contact lenses (SCLs) are developed to monitor some physiological information of the eye. Sculls can be used to continuously monitor eye diseases non‐invasively in real‐time. As a personal electronic device, SCs can aid people in understanding their physical condition better without affecting their personal life. This review mainly discusses the development direction and problems associated with sculls from the perspective of the IoT. SCs consist of three main parts: biosensors, circuits, and human–machine interface (HMI) systems. These three parts correspond to the sensing, connection, and application layer of the IoT. Finally, the problems that may be encountered in the development of SCLs are discussed and potential solutions are proposed.
Underwater Adhesion and Anti‐Swelling Hydrogels
Authors: Wang Siying , Liu Jingying , Wang Leichen , Cai Hao , Wang Qian , Wang Wenjun , Shao Jinjun , Dong Xiaochen 
Published: November 2022

AbstractWearable devices, biomaterials, and tissue engineering have all gained from the development of flexible materials. Hydrogels are made up of the polymer matrix in an amount of water and are now being explored extensively. Ascribed to their high hydrophilicity, conventional hydrogels are difficult to deal with high humidity, being easily swell and even decompose. The utilization of hydrogel underwater is influenced by two key factors: the hydrogel absorbs water and swells easily to depress the mechanical characteristics, and the hydration layer at the contact interface also prevents the hydrogel from making close contact with the target surface, preventing conformal and accurate smart perception. So far, many researchers have proposed satisfying improvements for underwater applications from these two perspectives. This review first summarizes the general mechanisms of underwater adhesion hydrogels. Then, various anti‐swelling strategies of the reported hydrogel are described. Finally, the existing challenges and prospects of underwater adhesion and anti‐swelling hydrogels are provided.
Optimum Combination of Radiopharmaceuticals‐Based Targeting‐Triggering‐Therapy Effect and PD‐L1 Blockade Immunotherapy
Authors: Wen Xuejun , Zeng Xinying , Shi Changrong , Liu Jia , Zhang Yiren , Shi Mengqi , Li Jingchao , Chen Haojun , Zhuang Rongqiang , Chen Xiaoyuan , Zhang Xianzhong , Guo Zhide 
Published: November 2022

AbstractThe therapeutic alliance of 177Lu radioligand therapy and immune checkpoint blockade (ICB) has gained increasing attention. This study aims to investigate the immunomodulatory effect (targeting‐triggering‐therapy) of 177Lu‐DOTA‐EB‐cRGDfK (177Lu‐DER) and to optimize the therapeutic efficacy by combining targeted radionuclide therapy (TRT) and ICB. Flow cytometry, immunofluorescence analysis, and RT‐qPCR are conducted to confirm the change of PD‐L1 expression. Tumor uptakes of 177Lu‐DER in CT26 and MC38 colorectal tumor models are verified through single photon emission computed tomography imaging. Further, the radionuclide dose and the treatment schedule to optimize the therapeutic scheme are carefully titrated and the mechanism of the synergy between TRT and ICB is explored. The results demonstrate that PD‐L1 expression is upregulated after irradiation of 177Lu. The combination of 9.25 MBq 177Lu‐DER TRT with 200 µg αPD‐L1 immunotherapy significantly inhibits tumor growth and protects against tumor recurrence. It is also found that 4‐h interval is an effective time window between radioligand administration and ICB therapy. In conclusion, a promising scheme for tumor immunotherapy is realized based on the sequential administration of integrin αvβ3‐targeted radioligand and PD‐L1 immune checkpoint blocker, emphasizing the potential of combining radiotheranostics with ICB for precision cancer therapy.
Sphere Last‐Passage Algorithm for Charge Density on a Smooth (Convex) Conducting Surface
Authors: Son Jinseong , Im Junhyeok , Hwang Chi‐Ok 
Published: November 2022

AbstractIn a series of papers, the authors have been developing last‐passage algorithms such as last‐passage algorithm and off‐centered last‐passage algorithm on a flat conducting surface, quadrupole last‐passage algorithm on an L‐shaped conducting surface, and last‐passage algorithm on a spherical conducting surface, held at (non)constant potentials. All the previous last‐passage algorithms can compute charge density at a specific point on a flat or spherical conducting surface only. In this paper, the last‐passage algorithms on any smooth (convex) surface for charge density at a specific point are further developed where a tangent plane can be constructed and a sphere can be put. The algorithm for charge density on a sphere, on a circular plate, and on the unit cube held at unit potential is demonstrated. The results show excellent agreements with theoretical or other simulation ones.
Degradation Mechanism and Enhancing Strategies of Oxygen Reduction Reaction Catalyzed by Carbon‐Based Metal Free Catalysts in Acidic Solution
Authors: Li Yan , Nong Wei , Zeng Zhihao , Wang Chengxin 
Published: November 2022

AbstractCarbon‐based metal free catalysts (CMFCs) are far away from commercial availability mainly attributed to their poor oxygen reduction reaction (ORR) performance in acidic environment with the causes remaining obscure. By investigating the heteroatoms (N, B, P, S, Se, and Te)‐doped reduced graphene oxides, the degradation mechanism of acidic ORR performance of CMFCs is found to be correlated with the oxygen‐baring defects in the carbon sp2 lattice, which exhibit overpotentials as low as 0.44 V but weak trapping capabilities for oxygen molecules. These findings not only revise the previously reported strategy of modeling the active sites in the basal plane of CMFCs but also highlight the connections between those active sites and the triple‐coordinated VIA group elements (XC3). Further calculations demonstrate that the XC3 dimer can efficiently enhance the acidic ORR performance and the 2D trigonal carbon‐chalcogenides C6X (X = S, Se, and Te) are accordingly designed toward acidic ORR, which contain homogeneously distributed basal plane active sites and exhibit low overpotentials but strong trapping capabilities for oxygen molecules. This work will help to cease the debates on the active sites in CMFCs for ORR in both acidic and alkaline solutions and to open a new avenue to design CMFCs independent on doping strategy.
Nanoporöse Filme mit regelmäßig angeordneten molekularen Motoren für lichtgesteuerte Adsorption und Diffusion
Authors: Jiang Yunzhe , Danowski Wojciech , Feringa Ben L. , Heinke Lars 
Published: November 2022

AbstractMolekulare Motoren sind faszinierende Nanomaschinen. Die Herstellung intelligenter Materialien aus solchen funktionalen Molekülen stellt jedoch eine große Herausforderung für die Materialwissenschaften dar. Hier stellen wir einen schichtweisen Aufbau von orientierten, regelmäßig angeordneten molekularen Motoren vor, die einen kristallinen nanoporösen metallorganischen Dünnfilm bilden. Während alle Stator‐Teile der synthetischen molekularen Motoren senkrecht zum Substrat ausgerichtet sind, zeigen die Rotor‐Teile in die Poren, welche groß genug sind, um die lichtinduzierte Molekülrotation zu ermöglichen. Auf Grund der Transparenz der dünnen Filme kann die Rotation des Motors und seine Aktivierungsenergie mittels UV/Vis‐Spektroskopie bestimmt werden. Zum ersten Mal werden molekulare Motoren in kristallinen porösen Materialien genutzt, um die Adsorptions‐ und Diffusionseigenschaften von Gastmolekülen in den Poren zu kontrollieren, hier, indem sie mit Licht zwischen den (meta‐)stabilen Zuständen geschaltet werden. Die Arbeit demonstriert das Potenzial von Materialien mit synthetischen molekularen Motoren und zeigt einen Weg für die zukünftige Entwicklung intelligenter Materialien.