bluuebunny/crossref_metadata_2025_split huggingface dataset:
Additive interaction of diabetes mellitus and chronic kidney disease in cancer patient mortality risk
Authors: Kim Seohyun , Kim Gyuri , Kim Jae Hyeon 
Published: November 2022

AbstractWe investigated the additive interaction of diabetes mellitus (DM) and chronic kidney disease (CKD) on the risk of mortality in cancer patients and evaluated the impact of diabetic kidney disease (DKD) on mortality in cancer patients with DM. We retrospectively analyzed 101,684 cancer patients. A multivariable Cox regression model was used for assessing mortality risk. Relative excess risk due to interaction (RERI), attributable proportion (AP), and synergy index (SI) were used to evaluate the additive interactive effect. The adjusted hazard ratio (aHR, 95%CI) for mortality was significant for those with CKD alone (1.53, 1.39–1.68), DM alone (1.25, 1.2–1.3), and both CKD and DM (1.99, 1.84–2.17) compared to non-CKD and non-DM cancer patients. The additive interaction between CKD and DM was significant (RERI 0.22[95%CI = 0.01–0.42], AP 0.11[0.01–0.21], SI 1.28[1.01–1.62]). Among cancer patients with DM, the presence of DKD raised the aHR for mortality (1.55, 95%CI = 1.33–1.81) compared to those without DKD. Coexistence of DM and CKD at the time of cancer diagnosis was significantly associated with an increased risk of mortality, and their interaction exerted an additive interactive effect on mortality. DKD was significantly associated with an increased risk of mortality in cancer patients with DM.
Research on highway traffic flow prediction model and decision-making method
Authors: Zhu Yuyu , Wu QingE , Xiao Na 
Published: November 2022

AbstractIn order to solve the problem of traffic congestion in a certain area, this paper develops a set of traffic optimization decision system. For analyzing the actual traffic conditions and calculating the traffic volume, density and traffic speed, a traffic prediction model is established and updated iteratively to modify the prediction model parameters. Based on this model, the congestion degree is estimated at the current road section, thus, an intelligent decision-making and the coordinated optimization methods are proposed. Moreover, this paper implements some application experiments on the isometric road of a three-intersection and obtains better prediction results of traffic density and traffic speed on the three-section highway. At the same time, compared with other existing prediction methods, the prediction model presented in this paper not only has higher accuracy, shorter prediction time and stronger anti-interference ability, but also has better effect on vehicle diversion. In addition, it also greatly relieves the traffic pressure on the road, maximizes the complementary advantages between intersections, and balances the good cooperation between each intersection.
Low intake of β carotene and dietary fiber from vegetables and fruits in patients with chronic kidney disease
Authors: Nakano Toshiaki , Tanaka Shigeru , Tsuruya Kazuhiko , Kitazono Takanari 
Published: November 2022

AbstractPatients with chronic kidney disease (CKD) occasionally need to restrict their consumption of vegetables and fruits. However, recent evidence suggests that plant-based diets have beneficial effects in patients with CKD. We aimed to determine the sufficiency of β carotene and dietary fiber intake in patients with CKD. We conducted a cross-sectional study among 4476 patients registered in the Fukuoka Kidney Disease Registry (FKR) study, a Japanese prospective cohort study of patients with CKD. Data from 3545 patients were analyzed after excluding cases with insufficient information. We evaluated the relationship between CKD stages and the intake of vegetables and fruits. The intake of β carotene and dietary fiber in CKD stages was evaluated using analysis of covariance. As the CKD stage advanced, the intake of vegetables, green leafy vegetables, and fruits significantly decreased (P-value for all trends < 0.01). The intake of vegetables significantly decreased as the CKD stage advanced (P for trend < 0.01). After adjusting for confounding factors, the intake of β carotene and dietary fiber also decreased (both P < 0.01) as the CKD stage advanced. Patients with CKD had insufficient vegetable and fruit intake and a lack of β carotene and dietary fiber from vegetables and fruits.
Research on the mechanism of information infrastructure affecting industrial structure upgrading
Authors: Zhang Pei , Wang Jiaoe , Li Mengming , Xiao Fan 
Published: November 2022

AbstractThe construction of information infrastructure as well as the transformation and upgrading of the industrial structure are among the major challenges for the Chinese economy. Therefore, it is of great significance to explore how information infrastructure affects the upgrading of industrial structure. Based on the panel data of 31 provinces in China from 2013 to 2020, mediating effect model and non-parametric percentile bootstrap method are used to carry out empirical research, by creating an information infrastructure construction level and industrial structure upgrading indicators. The results show that, in addition to the direct effect of information infrastructure on industrial structure upgrading, information infrastructure can also work indirectly through three paths: (1) information infrastructure acts on industrial structure upgrading by enhancing urbanization level; (2) information infrastructure affects industrial structure upgrading by boosting technological innovation; (3) information infrastructure first enhances urbanization level, then acts on technological innovation, and finally promotes industrial structure upgrading. In addition, the intermediary effect of technological innovation is stronger than urbanization. In general, this study acknowledges that urbanization and technological innovation are partial mediators in the process of information infrastructure affecting industrial structure upgrading, notwithstanding other potential impact pathways being studied further.
Association between serum calcium level and in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study
Authors: Fang Dingfeng , Chen Haibo 
Published: November 2022

AbstractThe association between serum calcium levels and the prognosis of patients with acute myocardial infarction (AMI) remains controversial. This study aimed to explore the association between serum calcium and in-hospital mortality in patients with AMI. The data of this study were extracted from the Philips eICU Collaborative Research Database. A total of 7284 patients were eventually enrolled in this study, of which 799 (10.97%) died during hospitalization. For each patient, serum calcium, corrected to albumin, was calculated and categorized into four groups: Q1 ≤ 8.5, Q2 8.5–9.5, Q3 9.5–10.5, and Q4 > 10.5 mg/dL. Multivariate analysis demonstrated that corrected sCa was an independent predictor of in-hospital death (Q2 vs. Q1, OR 0.5, 95% CI 0.4–0.7, P < 0.001; Q3 vs. Q1, OR 0.8, 95% CI 0.6–1.0, P = 0.035; Q4 vs. Q1, OR 1.6, 95% CI 1.1–2.3, P = 0.008). The association remained stable in the fully adjusted model. A significant U-shaped association between corrected serum calcium and in-hospital mortality was observed in piecewise linear regression model (Corrected sCa < 9.4 mg/dL, OR 0.8, 95% CI 0.7–0.9, P < 0.001; corrected sCa > 9.4 mg/dL, OR 1.5, 95% CI 1.3–1.8, P < 0.001). In conclusion, both decreased and increased corrected serum calcium is associated with increased in-hospital mortality in patients with AMI, and patients may have the lowest risk of in-hospital death when corrected serum calcium is 9.4 mg/dL (2.35 mmol/L).
High electrolyte uptake of MXene integrated membrane separators for Zn-ion batteries
Authors: Likitaporn Chutiwat , Okhawilai Manunya , Kasemsiri Pornnapa , Qin Jiaqian , Potiyaraj Pranut , Uyama Hiroshi 
Published: November 2022

AbstractThe recent development of separators with high flexibility, high electrolyte uptake, and ionic conductivity for batteries have gained considerable attention. However, studies on composite separators with the aforementioned properties for aqueous electrolytes in Zn-ion batteries are limited. In this research, a polyacrylonitrile (PAN)/bio-based polyurethane (PU)/Ti3C2Tx MXene composite membrane was fabricated using an electrospinning technique. Ti3C2 MXene was embedded in fibers and formed a spindle-like structure. With Ti3C2Tx MXene, the electrolyte uptake and ionic conductivity reached the superior values of 2214% and 3.35 × 10−3 S cm−1, respectively. The composite membrane presented an excellent charge–discharge stability when assembled in a Zn//Zn symmetrical battery. Moreover, the developed separator exhibited a high flexibility and no dimensional and structural changes after heat treatment, which resulted in the high-performance separator for the Zn-ion battery. Overall, the PAN/bio-based PU/Ti3C2Tx MXene composite membrane can be potentially used as a high-performance separator for Zn-ion batteries.
No associations between C-reactive protein and spinal pain trajectories in children and adolescents (CHAMPS study-DK)
Authors: Beynon Amber M. , Wedderkopp Niels , Walker Bruce F. , Leboeuf-Yde Charlotte , Hartvigsen Jan , Jones Bobby , Shrier Ian , Wang Chinchin , Hébert Jeffrey J. 
Published: November 2022

AbstractPreliminary evidence points to a link between C-reactive protein (CRP) and spinal pain in adults. However, there is a paucity of research in younger populations. Therefore, we aimed to determine associations between CRP and spinal pain in childhood and adolescence. We identified trajectories of spinal pain from childhood to adolescence and investigated the associations between CRP and trajectory subgroups. Six- to 11-year-old children from 13 primary schools, were followed from October 2008 and until 2014. High-sensitivity CRP collected at baseline (2008) was measured using serum samples. The outcome was the number of weeks with non-traumatic spinal pain between November 2008 and June 2014. We constructed a trajectory model to identify different spinal pain trajectory subgroups. The associations between CRP and spinal pain trajectory subgroups were modelled using mixed-effects multinominal logistic regression. Data from 1556 participants (52% female), with a mean age of 8.4 years at baseline, identified five spinal pain trajectory subgroups: “no pain” (55.3%), “rare” (23.7%), “rare, increasing” (13.6%), “moderate, increasing” (6.1%), and “early onset, decreasing” (1.3%). There were no differences in baseline high-sensitivity CRP levels between spinal pain trajectory subgroups. Thus, the heterogeneous courses of spinal pain experienced were not defined by differences in CRP at baseline.
Model experiments on hydraulic properties around multiple piers with reproduced 3D geometries
Authors: Sato Hirokazu 
Published: November 2022

AbstractThe effects of multiple piers with 3D geometries on water levels during floods, as well as riverbed fluctuations and local scour after floods were examined via hydraulic model experiments. The Kintaikyo Bridge in Japan, a world-famous historical triple-wooden-arch bridge, was modeled at a scale of approximately 1/276. The number of model piers was set to four, as in the real bridge, and they were 3D printed and installed in the sand layer of an open channel. To provide adequate information on the pier installation conditions and hydraulic response, four cases were studied in the experiments, primarily considering present pier conditions; the previous conditions of the Kintaikyo Bridge were also considered. The experimental conditions in these four cases depended on whether foundations were present, the piers were skewed against the flow center, and the shape was spindle or similar to that of the present case. In the current bridge condition where foundations are present and there is no skew, water level rise, riverbed fluctuation, and local scour were suppressed. Furthermore, the statistical analysis of the results suggested that riverbed fluctuations are more stable after flooding. The two piers with foundations had smaller scour areas than those without. Further, those with foundations generally had lower mean scour at the pier perimeters. Regarding those without foundations, there were no differences in riverbed fluctuations or local scour due to the skewed pier angle. In addition, the representative length of the pier with a 3D geometry was determined by dividing the projected area of the pier below the initial sand surface in the main flow direction by the pier height, and the relationship between the Froude number or the mean water depth and the maximum scour depth was investigated.
Intestinal preservation in a birdlike dinosaur supports conservatism in digestive canal evolution among theropods
Authors: Wang Xuri , Cau Andrea , Guo Bin , Ma Feimin , Qing Gele , Liu Yichuan 
Published: November 2022

AbstractDromaeosaurids were bird-like dinosaurs with a predatory ecology known to forage on fish, mammals and other dinosaurs. We describe Daurlong wangi gen. et sp. nov., a dromaeosaurid from the Lower Cretaceous Jehol Biota of Inner Mongolia, China. Exceptional preservation in this specimen includes a large bluish layer in the abdomen which represents one of the few occurrences of intestinal remnants among non-avian dinosaurs. Phylogenetically, Daurlong nests among a lineage of short-armed Jehol Biota species closer to eudromaeosaurs than microraptorines. The topographic correspondence between the exceptionally preserved intestine in the more stem-ward Scipionyx and the remnants in the more birdlike Daurlong provides a phylogenetic framework for inferring intestine tract extent in other theropods lacking fossilized visceral tissues. Gastrointestinal organization results conservative among faunivorous dinosaurs, with the evolution of a bird-like alimentary canal restricted to avialan theropods.
Discovering new potential inhibitors to SARS-CoV-2 RNA dependent RNA polymerase (RdRp) using high throughput virtual screening and molecular dynamics simulations
Authors: Brunt Dylan , Lakernick Phillip M. , Wu Chun 
Published: November 2022

AbstractRNA dependent RNA polymerase (RdRp), is an essential in the RNA replication within the life cycle of the severely acute respiratory coronavirus-2 (SARS-CoV-2), causing the deadly respiratory induced sickness COVID-19. Remdesivir is a prodrug that has seen some success in inhibiting this enzyme, however there is still the pressing need for effective alternatives. In this study, we present the discovery of four non-nucleoside small molecules that bind favorably to SARS-CoV-2 RdRp over the active form of the popular drug remdesivir (RTP) and adenosine triphosphate (ATP) by utilizing high-throughput virtual screening (HTVS) against the vast ZINC compound database coupled with extensive molecular dynamics (MD) simulations. After post-trajectory analysis, we found that the simulations of complexes containing both ATP and RTP remained stable for the duration of their trajectories. Additionally, it was revealed that the phosphate tail of RTP was stabilized by both the positive amino acid pocket and magnesium ions near the entry channel of RdRp which includes residues K551, R553, R555 and K621. It was also found that residues D623, D760, and N691 further stabilized the ribose portion of RTP with U10 on the template RNA strand forming hydrogen pairs with the adenosine motif. Using these models of RdRp, we employed them to screen the ZINC database of ~ 17 million molecules. Using docking and drug properties scoring, we narrowed down our selection to fourteen candidates. These were subjected to 200 ns simulations each underwent free energy calculations. We identified four hit compounds from the ZINC database that have similar binding poses to RTP while possessing lower overall binding free energies, with ZINC097971592 having a binding free energy two times lower than RTP.
The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition
Authors: van der Meer Dennis , Gurholt Tiril P. , Sønderby Ida E. , Shadrin Alexey A. , Hindley Guy , Rahman Zillur , de Lange Ann-Marie G. , Frei Oleksandr , Leinhard Olof D. , Linge Jennifer , Simon Rozalyn , Beck Dani , Westlye Lars T. , Halvorsen Sigrun , Dale Anders M. , Karlsen Tom H. , Kaufmann Tobias , Andreassen Ole A. 
Published: November 2022

AbstractObesity and associated morbidities, metabolic associated fatty liver disease (MAFLD) included, constitute some of the largest public health threats worldwide. Body composition and related risk factors are known to be heritable and identification of their genetic determinants may aid in the development of better prevention and treatment strategies. Recently, large-scale whole-body MRI data has become available, providing more specific measures of body composition than anthropometrics such as body mass index. Here, we aimed to elucidate the genetic architecture of body composition, by conducting genome-wide association studies (GWAS) of these MRI-derived measures. We ran both univariate and multivariate GWAS on fourteen MRI-derived measurements of adipose and muscle tissue distribution, derived from scans from 33,588 White European UK Biobank participants (mean age of 64.5 years, 51.4% female). Through multivariate analysis, we discovered 100 loci with distributed effects across the body composition measures and 241 significant genes primarily involved in immune system functioning. Liver fat stood out, with a highly discoverable and oligogenic architecture and the strongest genetic associations. Comparison with 21 common cardiometabolic traits revealed both shared and specific genetic influences, with higher mean heritability for the MRI measures (h2 = .25 vs. .13, p = 1.8x10−7). We found substantial genetic correlations between the body composition measures and a range of cardiometabolic diseases, with the strongest correlation between liver fat and type 2 diabetes (rg = .49, p = 2.7x10−22). These findings show that MRI-derived body composition measures complement conventional body anthropometrics and other biomarkers of cardiometabolic health, highlighting the central role of liver fat, and improving our knowledge of the genetic architecture of body composition and related diseases.
Chronic oligodendrocyte injury in central nervous system pathologies
Authors: Molina-Gonzalez Irene , Miron Veronique E. , Antel Jack P. 
Published: November 2022

AbstractMyelin, the membrane surrounding neuronal axons, is critical for central nervous system (CNS) function. Injury to myelin-forming oligodendrocytes (OL) in chronic neurological diseases (e.g. multiple sclerosis) ranges from sublethal to lethal, leading to OL dysfunction and myelin pathology, and consequent deleterious impacts on axonal health that drive clinical impairments. This is regulated by intrinsic factors such as heterogeneity and age, and extrinsic cellular and molecular interactions. Here, we discuss the responses of OLs to injury, and perspectives for therapeutic targeting. We put forward that targeting mature OL health in neurological disease is a promising therapeutic strategy to support CNS function.
Role of formaldehyde in promoting aromatic selectivity during methanol conversion over gallium-modified zeolites
Authors: Wen Wu , Xiao Tianci , Feng Beibei , Zhou Chaoqun , Li Jian , Ma Hao , Zhou Zhongyue , Zhang Ying , Yang Jiuzhong , Wang Zhandong , Qi Fei , Bao Jun , Liu Chengyuan , Pan Yang 
Published: November 2022

AbstractGallium-modified HZSM-5 zeolites are known to increase aromatic selectivity in methanol conversion. However, there are still disputes about the exact active sites and the aromatic formation mechanisms over Ga-modified zeolites. In this work, in situ synchrotron radiation photoionization mass spectrometry (SR-PIMS) experiments were carried out to study the behaviors of intermediates and products during methanol conversion over Ga-modified HZSM-5. The increased formaldehyde (HCHO) yield over Ga-modified HZSM-5 was found to play a key role in the increase in aromatic yields. More HCHO was deemed to be generated from the direct dehydrogenation of methanol, and Ga2O3 in Ga-modified HZSM-5 was found to be the active phase. The larger increase in aromatic production over Ga-modified HZSM-5 after reduction‒oxidation treatment was found to be the result of redispersed Ga2O3 with smaller size generating a larger amount of HCHO. This study provides some new insights into the internal driving force for promoting the production of aromatics over Ga-modified HZSM-5.
Catalytic asymmetric synthesis of carbocyclic C-nucleosides
Authors: Mishra Sourabh , Modicom Florian C. T. , Dean Conor L. , Fletcher Stephen P. 
Published: November 2022

AbstractAccess to carbocyclic C-nucleosides (CC-Ns) is currently restricted. The few methods available to make CC-Ns suffer from long syntheses and poor modularity, hindering the examination of potentially important chemical space. Here we report an approach to CC-Ns which uses an asymmetric Suzuki-Miyaura type reaction as the key C-C bond forming step. After coupling the densely functionalized racemic bicyclic allyl chloride and heterocyclic boronic acids, the trisubstituted cyclopentenyl core is elaborated to RNA analogues via a hydroborylation-homologation-oxidation sequence. We demonstrate that the approach can be used to produce a variety of enantiomerically enriched CC-Ns, including a carbocyclic derivative of Showdomycin.
Target-oriented design of helical nanotube molecules for rolled incommensurate bilayers
Authors: Isobe Hiroyuki , Kotani Yuki , Matsuno Taisuke , Fukunaga Toshiya M. , Ikemoto Koki 
Published: November 2022

AbstractIncommensurate double-wall carbon nanotubes give rise to unique stereochemistry originating from twisted stacks of hexagon arrays. However, atomic-level studies on such unique systems have rarely been performed, even though syntheses of molecular segments of carbon nanotubes have been extensively explored. The design of cylindrical molecules with chirality, particularly, in pairs provides synthetic challenges, because relationships between diameters specified with chiral indices and structures of arylene panels have not been investigated in a systematic manner. Here we show that a molecular version of incommensurate double-wall carbon nanotubes can be designed through the development of an atlas for the top-down design of cylindrical molecules. A large-bore cylindrical molecule with a diameter of 1.77 nm was synthesized using a readily available pigment and encapsulated a small-bore cylindrical molecule with a diameter of 1.04 nm. The large- and small-bore molecules possessed helicity in atomic arrangements, and their coaxial assembly proceeded in nonstereoselective manner to give both heterohelical and homohelical combinations.
Transport properties of dipole skyrmions in amorphous Fe/Gd multilayers
Authors: Montoya Sergio A. , Lubarda Marko V. , Lomakin Vitaliy 
Published: November 2022

AbstractChiral magnets are known to possess interesting electromagnetic properties that result from the coupling of electrons with nontrivial magnetic phases, such as particle-like magnetic spin textures termed skyrmions. So far, it is unclear how the local and global chirality of magnetic spin textures contributes to the electromagnetic transport responses that have so far been observed. In this work, we focus on unraveling the contributions in the field-dependent longitudinal resistivity response that arises from magnetic spin textures in a centrosymmetric Fe/Gd multilayer that exhibits an array of magnetic phases ranging from stripe, mixed stripe-skyrmion, skyrmion lattice, and disordered skyrmion. Using a combination of transport measurements and micromagnetic simulations, we demonstrate a domain wall chirality reconfiguration occurs as the domain morphology transitions from disordered stripe to skyrmion lattice phase under applied fields that is responsible for the interesting transport responses noted in the field-dependent longitudinal resistivity.