bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between socioeconomic status, response inhibition, and state and trait anxiety in Chinese adolescents
Authors: Zhao Xin , Li Fanxia , Maes Joseph H.R. 
Published: November 2022

Abstract

Response inhibition ability is assumed to play a vital role in many behavioral and health outcomes. Research on identifying correlates of response inhibition might inform theoretical considerations on causes and effects of this ability, and ultimately interventions. This study focused on two such correlates, for which there is a lack of research and/or mixed findings: childhood socioeconomic status (SES) and state and trait anxiety. A sample of 463 Chinese high school students, aged 14–18 years, filled in questionnaires on childhood SES and trait and state anxiety, and performed a go/no-go response inhibition task. Significant positive associations were found between SES and various measures of response inhibition ability. Moreover, SES was negatively associated with both types of anxiety, which were negatively associated with indices of response inhibition ability. Also based on exploratory ad-hoc mediation and modulation analyses, these associations were discussed in terms of possible causal relations among the variables.
Towards potent Covid-19 spike protein inhibitors and catecholase activity agents: Synthesis, ADME-Tox analysis and molecular docking of new 1,2,4- triazole-based molecules
Authors: Zerrouki Abdelkhalek , Abrigach Farid , Taleb Mustapha , Kadiri Sghir El 
Published: November 2022

Abstract

The discovery of new efficiency therapeutic agents that can block the adhesion of the transmembrane glycoprotein Spike (S-protein) to the human angiotensin-converting enzyme 2 (hACE2) receptor remains one of the most investigated strategies to fight against Covid-19 pandemic. In this context, new triazole derivatives have been synthesized through condensation reactions between (1H-1, 2, 4-triazol-1-yl)methanol and different secondary amines. Their chemical scaffolds were well illuminated by1H/13C/ COSY/ HSQC NMR, FT-IR and mass spectroscopies.In silicoinvestigations have been carried out. ADME-Tox screening revealed that the prepared compounds could serve as excellent oral candidate drugs with optimal pharmacokinetic proprieties and toxicological profiles. Molecular docking simulations against the isolated S-RBD protein and SARS-CoV-2-RBD- hACE2 complex showed that our compounds could form important hydrogen, hydrophobic and electrostatic interactions with some key residues that ensure the binding of the S-protein to its hACE2 receptor making them good candidate agents that can block or prevent the entry of SARS-CoV-2 virus in the host cell. Additionally, catecholase activity of the tridentate ligands have been studied. The obtained findings demonstrated that a systematic variation of the ligand substituent and metallic salts types, significantly influences the interaction of thein situcomplexes with catechol and hence the oxidase biomimetic catalytic activities. Complex L3/Cu(CH3COO)2was found to exhibit the highest activity towards oxidation of catechol to its corresponding quinone with a rate of 2.44 𝜇mol.l−1.min−1.
Optimization of electroosmotic flow to enhance the removal of contaminants from low permeable soils
Authors: Hussain Abdul Ahad , Akram Aasma 
Published: November 2022

Abstract
Electrokinetic is the effective method for the extraction of contamination from low permeable soil. This work examines the influence of calcium ions on the electroosmosis, and the effects of electric potential, current, and pH variation on the removal of Pb2+, Na+, and Clˉ ions from artificially contaminated soil during vertical electrokinetic experiments. The DC electric field of 1V/cm was applied across the soil specimen via steel mesh electrodes for 24, 48 and 72 hours of experiment. The outcomes show that the formation of acidic and alkaline environments in soil specimens affects the transport of ionic charge species by reducing the effect of electroosmosis. To enhance the electroosmotic flow, the anode reservoir filled with and without calcium chloride solution was examined. The enhancement of electroosmosis using calcium ions as an electrolyte increased the extraction efficiency of Pb2+ and Na+ ions instead of the Clˉ ions due to the high electroosmotic flow from anode to cathode. For relatively low electroosmotic flow, the removal rate of Clˉ ions was higher than the Pb2+ and Na+ ions. The results demonstrated that the extraction efficiency was increased with an increase in the treatment time. To avoid the dryness of the soil surface, wet sponges were inserted at the anode side, which connected with the electrolyte.
Changes in functional brain activity patterns associated with computer programming learning in novices
Authors: Hishikawa Kenji , Yoshinaga Kenji , Togo Hiroki , Hongo Takeshi , Hanakawa Takashi 
Published: November 2022

Abstract
Background
Computer programming, the process of designing, writing, and testing executable computer code, is an essential skill in numerous fields. A description of the neural structures engaged and modified during programming skill acquisition could help improve training programs and provide clues to the neural substrates underlying the acquisition of related skills.
Methods
Fourteen female university students without prior computer programing experience were examined by functional magnetic resonance imaging (fMRI) during the early and late stages of a 5-month ‘Computer Processing’ course. Brain regions involved in task performance and learning were identified by comparing responses to programming and control tasks during the early and late stages.
Results
The accuracy of programming task performance was significantly improved during the late stage. Various regions of the frontal, temporal, parietal, and occipital cortex as well as several subcortical structures (caudate nuclei and cerebellum) were activated during programming tasks. Brain activity in the right inferior frontal gyrus was greater during the late stage and significantly correlated with task performance. Learning was also associated with a rightward shift in laterality of the bilateral inferior frontal gyri. Although the left inferior frontal gyrus was also highly active during the programming task, there were no learning-induced changes in activity nor a significant correlation between activity and task performance.
Conclusion
Computer programming learning among novices induces functional neuroplasticity within the right inferior frontal gyrus but not the left inferior gyrus (Broca’s area).
Assessment of vasa vasorum on plaque components and no-reflow phenomenon by intravascular ultrasound and iMap analysis
Authors: Wu Xi , Cai Xin-Yu , Wang Quan , Ji Gang , Yan Yan , Song Jing , Chen Jing , Huang He 
Published: November 2022

Abstract
Purpose

Previously, researches have revealed that vasa vasorum (VV) neovascularisation is vital for the progression and vulnerability of coronary atherosclerosis plaque. Our team explored plaque constituents in iMap-intravascular ultrasound (iMap-IVUS) and no-reflow phenomenon (NRP) in the course of percutaneous coronary intervention (PCI) for lesions with VV.

Methods

Our team studied 385 coronary lesions in 361 patients (169 lesions with VV) undergoing pre-intervention IVUS. The diversities in plaque morphological status and post-PCI results were evaluated as per the presence or absence of VV.

Results

Lesions with VV were more frequently identified in acute coronary syndrome (ACS) patients (69.8% vs. 22.2%, P < 0.001).Plaques at the minimum lumen area, necrotic core area (1.24 ± 0.53mm2 vs. 1.24 ± 0.53mm2, P < 0.001;17.13 ± 6.67% vs.17.13 ± 6.67%, P < 0.001) and fibrous area (4.30 ± 0.90mm2 vs. 4.09 ± 1.00mm2, P = 0.033; 60.29 ± 8.24% vs. 58.04 ± 12.29%, P = 0.041) were considerably larger in the lesion with VV than in the lesion without VV. In addition,densely calcified plaques (0.40 ± 0.24mm2 vs. 0.79 ± 0.63mm2, P < 0.001; 5.72 ± 3.23% vs.11.63 ± 10.06%, P < 0.001) were considerably smaller in the lesion with VV than in the lesion without VV. Multivariate analyses revealed that VV and plaque volume were independent prediction factors of NRP posterior to stent deployment (odds ratio 0.091, 95% CI 0.039–0.210, P ＜0.001;odds ratio 0.949, 95% CI 0.921–1.979, P = 0.001).

Conclusions

Lesions with VV displayed great plaque vulnerability and were more frequently identified in ACS patients,, and they displayed more NRP in the course of PCI in contrast to lesions without VV. Multivariate analyses revealed that VV and plaque volume were independent prediction factors of NRP posterior to stent deployment.
The prevalence of common mental disorders among the students of Kuwait university after the Covid-19 pandemic
Authors: Haggag Abdelmotaleb Abdelkader 
Published: November 2022

Abstract
Background: Previous studies indicated that the mental health of college students was a growing concern even before the COVID-19 pandemic. Community-based surveys report a high prevalence of mental disorders among college students, the most common being OCD, anxiety and depression. The factors causing the high rates of mental disorders differ from one society to another as a result of the different cultural, social, economic and political systems of each society.
Methods: This research aimed to know the prevalence of common mental disorders among the students of Kuwait university after the Covid-19 pandemic. An Internet-based cross-sectional study was conducted where the participants from students of Kuwait university were targeted using total population sampling. 380 participants from students of Kuwait university were recruited, between September18 and December8, 2021. Participants completed sociodemographic data and the Brief Symptom Inventory (BSI).
Results: The results reveal that there is moderate level of mental disorders among participants. About 17% of the participants high level of mental disorders. About 42.6% of the participants moderate level of mental disorders. Obsessive-compulsive was coming in the first order. Depression was coming in the second order. Somatization was coming in the third order. Interpersonal Sensitivity was coming in the fourth order. The groups most suffering from mental disorders were students studying natural sciences and females.
Conclusions: 17% of the participants high level of mental disorders was found. This study recommended that providing guidance programs to educate male and female students in universities about the importance of maintaining mental health and treatment in cases of obsessive-compulsive disorder, anxiety and depression. Develop the positive aspects of university students, such as developing talents and practicing sports.
DETECTION OF GAS LEAKAGE IN AIR CONDITIONER
Authors: M. SUSARITHA , CHANDRU S. GOKUL , M. EZHILARASAN , K.R ANISH 
Published: November 2022

Abstract
In this paper we are going to monitor the gas leakage in the air conditioner. Commonly a small leakage of gas may gradually build up an explosive concentration of gas. This project monitors the gas leakage in the air conditioner by using the gas sensor. Leakage of gas and smoke present inside a room is found by using a gas sensor. This project used Arduino UNO as the Microcontroller where it process the input from the sensor. If gas leakage is detected, then the system gives alert alarm by using a buzzer sound and sent SMS through GSM module to communicate with the user.
Efficiency Dynamics and Productivity Analysis of Manufacturing Industries in Bangladesh
Authors: Sanusi Olajide , Adeeko Omotara 
Published: November 2022

Abstract

In this study we use the stochastic frontier model in estimating total factor productivity (TFP) growth and technical efficiencies for manufacturing industries in Bangladesh by using surveys collected during five rounds in 1982/83, 1984/85, 1988/89, 2005/06 and 2012. To detect the source of growth, we further decompose Total Factor Productivity growth into efficiency growth, scale component, and technological progress. Our result establishes that, on average, technical efficiency was 80%, noting that the export focused industries are comparatively more efficient than non-export focused industries. Furthermore, medium, and large-scale industries have a lower TFP growth than small scale industries. Furthermore, the Total Factor Productivity growth estimations shows that productivity in the manufacturing industries in Bangladesh was approximately 5.5% in the review period illustrating that technological progress is a major driver of growth. Additionally, this study provides evidence on the likelihood of TFP growth convergence over time among the manufacturing industries in Bangladesh.
Neuroprotective and Neuroregenerative Effects of Shikonin-mediated
Inhibition of NF-κB/Stat3 in Alcoholic Encephalopathy
Authors: Zyuz’kov Gleb Nikolaevich , Miroshnichenko Larisa Arkad`evna , Polyakova Tatyana Yur`evna , Simanina Elena Vladislavovna 
Published: November 2022

Background:
Targeting intracellular signaling molecules in nervous tissue progenitors is a
promising basis for the development of novel neurodegenerative disease therapy approaches. Naphthoquinone
shikonin from the root of Lithospermum erythrorhizon is known to have inhibitory effects on
NF-κB and STAT3.

Objective:
This study aimed to explore the influence of shikonin on the functioning of progenitors of
nervous tissue and its neuroprotective properties in the modeling of alcoholic encephalopathy (AE).

Methods:
Experiments were performed on C57B1/6 male mice. AE was modeled by prolonged intragastric
administration of ethanol. We studied the exploratory behavior and conditioned reflex activity in
laboratory animals, as well as the functioning of neural stem cells (NSCs) and neuronal committed progenitors
(NCPs) of the subventricular zone of the cerebral hemispheres. NCPs were obtained using the
immunomagnetic separation method. The direct in vitro effects of the shikonin on the colony-forming
capacity of progenitors, their proliferative activity, and intensity of specialization were compared with the
effects of synthetic NF-κB and STAT3 inhibitors.

Results:
Results of in vitro experiments showed that the influence of phytochemicals was similar to the
effects of synthetic NF-κB and STAT3 inhibitors. Shikonin stimulated the proliferation of NSCs and
NCPs. In vivo shikonin administration caused the normalization of exploratory behavior and conditioned
reflex activity of mice with AE. These effects developed after an increase in NSCs and NCPs content in
the subventricular zone of the cerebral hemispheres due to an increase in their proliferative activity. The
intensity of specialization of progenitors was also accelerated.

Conclusion:
The findings indicated the promise of developing a novel approach to the treatment of AE
based on shikonin-mediated inhibiting of NF-κB/STAT3.
Arch Measurement Changes upon Biomimetic Oral Appliance Therapy for Adults with Obstructive Sleep Apnea
Authors: Al Mortadi Noor , Khassawneh Basheer , Khasawneh Lina , Alzoubi Karem H. 
Published: November 2022

Background:
Obstructive Sleep Apnea (OSA) is the most common form of sleep disordered breathing. Patients who arrive at the dental office with a diagnosis of OSA are often treated with a mandibular advancement device (MAD). A biomimetic oral appliance therapy (BOAT) offers an alternative nonsurgical method, which can putatively resolve OSA by combining maxilla-mandibular correction and addressing craniofacial deficiencies.

Aim:
To determine whether maxilla-mandibular correction changes induced by BOAT produce a more favorable upper airway, which might result in a reduction in the severity of OSA.

Methods:
Patients who were diagnosed with mild to moderate obstructive sleep apnea (OSA, 9 males, 8 females; age, mean (SD): 45.76(10.31), BMI mean (SD): 33.5(13.43), underwent BOAT therapy. Subjects had 2 months of follow-up visits, including examinations for progress and adjustment of the appliances. The mean apnea-hypopnea index (AHI) with no appliance in the mouth prior to BOAT and after treatment was recorded. The mid-palatal screw mechanism of the appliance was advanced once per week. The subjects were asked to wear the appliance for 10-12 hours/day and night. Paired T-Test was used to analyze the results.

Results:
The BOAT treatment enhanced upper airway function as the total AHI was significantly lower after treatment (P=0.019). Parameters that were significantly improved by the end of the treatment period included total AHI/Per hour of sleep (p=0.019), NREM-AHI (p=0.019), desaturation index (p=0.041), average SpO2 (p=0.088), and average O2 while in non-REM (p=0.043). Measurements of jaw changes were all statistically significant except lower 6-6 and lower 7-7. Additionally, a strong negative correlation between AHI and jaw changes was shown for upper 6-6 (p=-0.52), upper 7-7 (p=-0.48), and lower 3-3 (p=-0.42).

Conclusion:
The BOAT provides a useful form of therapy for the resolve of OSA. This study suggests that BOATS may be able to reduce the AHI to within normal limits. Still, long-term follow-up is needed to determine whether these subjects need a maintenance program to retain their initial upper airway improvement.
Analysis of Publication Activity and Research Trends in the Field of Lichen Planus: Pubmed Review
Authors: Khakimova Aida , Zolotarev Oleg 
Published: November 2022

Background:
Currently, there is only one bibliometric study of lichen planus (LP) and oral lichen planus (OLP) in the literature, which examined the most cited articles in the Scopus database. Our study covered all published articles in the PubMed database for 140 years since, from 1880 to 2021. In addition to the classical bibliometric analysis, we conducted a lexical analysis of key terms to build research trends in the oral lichen planus.

Aims:
Analysis of publication activity in the field of lichen planus by countries, their economic status and population, as well as identification of concomitant diseases by lexical analysis of key terms extracted from headings and abstracts over the past 20 years.

Methods:
Information from the PubMed database was retrieved automatically based on a query for the period from 1880 to 2021, including the field: title, abstract, authors, and year of publication. A total of 8173 articles were retrieved. The selection of keywords and identifying trends in related terminology were done using expert and automatic methods.
An analysis of publication activity by country and socio-economic indicators was carried out. With the help of neural network analysis, the most characteristic terms related to LP were identified. Common terms were ranked by occurrence in titles and abstracts.

Results:
Publication activity in the field of LP and OLP has especially increased in the 21st century. The United States is the most productive country. China is a leader among countries with economies in transition. India is a leader among emerging economies. LP research is distributed worldwide. Finland ranks first in the number of publications per capita. The temporal dynamics of terminology are noted, including an increase in the number of terms used in any field of science (hereinafter referred to as general scientific terms).

Conclusion:
Publication activity in the field of LP and OLP has increased significantly in the 21st century. The highest publication activity was observed among authors from India, the USA and China. The leaders among economically developed countries are Italy, among the countries with economies in transition - China, and among the emerging economies - India. Based on lexical analysis of key terms, the following concomitant diseases were identified: carcinoma, leukoplakia, hepatitis, and lupus.
Discontinuation of specialist educational provision for children with DLD in the Netherlands: performance and predictors
Authors: Boerma Tessel , Wijnen Frank , Blom Elma 
Published: November 2022

Achtergrond. Taalontwikkelingsstoornis (TOS) wordt gekenmerkt door grote heterogeniteit, maar er is nog weinig bekend over de variatie in specialistische onderwijsondersteuning voor kinderen met TOS. Dit longitudinale onderzoek bestudeerde de taal- en leesvaardigheid van kinderen met TOS bij wie onderwijsondersteuning op 7- of 8-jarige leeftijd beëindigd werd en kinderen met TOS bij wie dit werd voortgezet, ten opzichte van typisch ontwikkelende kinderen. Daarnaast onderzochten we talige, cognitieve en omgevingsfactoren als voorspellers voor de beëindiging van specialistische onderwijsondersteuning.
Methode. Eentalige en meertalige kinderen met (n=120) en zonder (n=113) TOS namen deel aan het onderzoek. Gestandaardiseerde instrumentenwerden gebruikt om de proportie van kinderen per groep met zwakke taal- en leesvaardigheid op 7- of 8-jarige leeftijd te beschrijven. Binaire logistische regressie werd uitgevoerd om de beëindiging van specialistische onderwijsondersteuning te voorspellen. Voorspellers waren talige en cognitieve vaardigheden op 5- of 6-jarige leeftijd, groei in taalvaardigheid, onderwijsniveau van ouders en meertaligheid.
Resultaten. Totaal had 25% van de kinderen met TOS geen specialistische onderwijsondersteuning meer op 7- of 8-jarige leeftijd. Meer meertaligen dan eentaligen behielden onderwijsondersteuning, hoewel dit verschil net niet significant was. Kinderen met TOS, zowel met als zonder onderwijsondersteuning, scoorden vaker zwak op de gestandaardiseerde instrumenten dan typisch ontwikkelende kinderen. Kinderen met TOS met specialistische onderwijsondersteuning presteerden vaker zwak dan kinderen met TOS zonder ondersteuning. Onderwijsniveau van ouders en morfologische vaardigheden, zowel op baseline als groei, voorspelden de beëindiging van onderwijsondersteuning.
Conclusies en implicaties. Specialistische onderwijsondersteuning bleek voor veel kinderen met TOS binnen een relatief kort tijdsbestek beëindigd te zijn. Hoewel deze kinderen sterker presteerden dan leeftijdsgenoten met TOS die ondersteuning behielden, was hun taal- en leesvaardigheid vaak zwak. Deze groep blijft dus kwetsbaar en behoeft aandacht. Vervolgonderzoek naar besluitvorming omtrent specialistische onderwijsondersteuning is nodig om de rol van onderwijsniveau van ouders en morfologische vaardigheden in de beëindiging van ondersteuning te begrijpen.