bluuebunny/crossref_metadata_2025_split huggingface dataset:
A geospatial and binomial logistic regression model to prioritize sampling for per- and polyfluorinated alkyl substances in public water systems
Authors: Ojha Sweta , Li Ying , Rezaei Nader , Robinson Ariel , Hoover Anna , Pennell Kelly G. 
Published: April 2022

Abstract
As health-based drinking water standards for per- and polyfluorinated alkyl substances (PFAS) continue to evolve, public health and environmental protection decision-makers must assess exposure risks associated with all public drinking water systems in the United States (US). Unfortunately, current knowledge regarding the presence of PFAS in environmental systems is limited. In this study, a screening approach was established to: (1) identify and direct attention toward potential PFAS hot spots in drinking water sources, (2) prioritize sampling locations, and (3) provide insights regarding the potential PFAS sources that contaminate groundwater and surface water. Our approach incorporates geospatial data from public sources, including the US Environmental Protection Agency's Toxic Release Inventory, to identify locations where PFAS may be present in drinking water sources. An indicator factor (also known as “risk factor”) was developed as a function of distance between potential past and/or present PFAS users (e.g., military bases, industrial sites, and airports) and the public water system, which generates a heat map that visualizes potential exposure risks. A binomial logistic regression model indicates whether PFAS are likely to be detected in public water systems. The results obtained using the developed screening approach aligned well (with a 76% overall model accuracy) with PFAS sampling and chemical analysis data from 81 public drinking water systems in the state of Kentucky. This study proposes this screening model as an effective decision aid to assist key decision-makers in identifying and prioritizing sampling locations for potential PFAS exposure risks in the public drinking water sources in their service areas. Integr Environ Assess Manag 2023;19:163–174. © 2022 SETAC
Using life-history trait variation to inform ecological risk assessments for threatened and endangered plant species
Authors: Rueda-Cediel Pamela , Galic Nika , Brain Richard , Pinto-Ledezma Jesús N. , Rico Andreu , Forbes Valery 
Published: April 2022

Abstract
Developing population models for assessing risks to terrestrial plant species listed as threatened or endangered under the Endangered Species Act (ESA) is challenging given a paucity of data on their life histories. The purpose of this study was to develop a novel approach for identifying relatively data-rich nonlisted species that could serve as representatives for species listed under the ESA in the development of population models to inform risk assessments. We used the USDA PLANTS Database, which provides data on plants present in the US territories, to create a list of herbaceous plants. A total of 8742 species was obtained, of which 344 were listed under the ESA. Using the most up-to-date phylogeny for vascular plants in combination with a database of matrix population models for plants (COMPADRE) and cluster analyses, we investigated how listed species were distributed across the plant phylogeny, grouped listed and nonlisted species according to their life history, and identified the traits distinguishing the clusters. We performed elasticity analyses to determine the relative sensitivity of population growth rate to perturbations of species' survival, growth, and reproduction and compared these across clusters and between listed and nonlisted species. We found that listed species were distributed widely across the plant phylogeny as well as clusters, suggesting that listed species do not share a common evolution or life-history characteristics that would make them uniquely vulnerable. Lifespan and age at maturity were more important for distinguishing clusters than were reproductive traits. For clusters that were intermediate in their lifespan, listed and nonlisted species responded similarly to perturbations of their life histories. However, for clusters at either extreme of lifespan, the response to survival perturbations varied depending on conservation status. These results can be used to guide the choice of representative species for population model development in the context of ecological risk assessment. Integr Environ Assess Manag 2023;19:213–223. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Are standard aquatic test species and methods adequate surrogates for use in environmental risk assessment of pesticides in tropical environments?
Authors: Santos Gustavo S. , Hamer Mick , Tscheschke Alexandra , Bruns Eric , Murakami Lucilene , Dohmen Gerhard P. 
Published: April 2022

Abstract
In regulatory risk assessment, surrogate species of fish, aquatic invertebrates, and primary producers are tested to assess toxicity and subsequently the risk of pesticides to freshwater biota. This study evaluates whether the standard, surrogate test species (mostly temperate in latitudinal distribution) used in many parts of the world are suitable surrogates for first-tier risk assessments involving tropical freshwater biota. Data for the toxicity of pesticides to tropical fish, invertebrates, and primary producer species were extracted from the USEPA ECOTOX database and peer-reviewed literature. For each pesticide, the most sensitive regulatory endpoint extracted from the US Environmental Protection Agency (USEPA) and European Food Safety Authority (EFSA) dossiers for freshwater fish, invertebrates, and primary producers was selected. The ratios of the endpoint for tropical species and for the most sensitive regulatory endpoint for the appropriate taxonomic group were determined. A value &gt;1 indicates that the tropical species is less sensitive than the respective standard regulatory species. Tropical fish species were less sensitive than standard fish species in 84% of the comparisons, and in 93.5% of the comparisons, tropical fish were less or similarly sensitive (within a factor of 5). For aquatic invertebrates, 78.1% of the evaluated tropical species were less sensitive than standard species and 93.3% of tropical invertebrates species were less or similarly sensitive. For primary producers, 96% of tropical species were less sensitive than standard test species. Overall, standard species used globally were more sensitive or similarly sensitive compared to tropical species in more than 93% of the cases. In conclusion, the data show that freshwater toxicity data for pesticides from tests using standard test species, tested according to international accepted guidelines, are appropriate for use in first-tier risk assessments for tropical environments. Integr Environ Assess Manag 2023;19:202–212. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Outcomes associated with different surgical approaches to radical hysterectomy: A systematic review and network meta‐analysis
Authors: Guo Xinmeng , Tian Shuang , Wang Hui , Zhang Jinning , Cheng Yanfei , Yao Yuanqing 
Published: April 2022

AbstractObjectiveTo evaluate the efficacy and safety of five different approaches to cervical cancer surgery.MethodsWe conducted a systematic search for comparative studies on different radical hysterectomy types for cervical cancer in PubMed, Embase, the Cochrane Library, and Web of Science databases. All included observational studies used survival analyses to compare clinical outcomes of patients undergoing different radical hysterectomy types. All studies were assessed by the Newcastle‐Ottawa Scale with scores of at least seven points. We extracted the relevant data and conducted a network meta‐analysis to compare clinical outcomes among five surgical approaches.ResultsThirty studies (n = 11 353) were included. Robotic surgery had the lowest blood loss volume and hospitalization duration; open surgery had the shortest operative time. Vaginal assisted laparoscopic surgery was associated with the highest number of resected lymph nodes and lowest rate of perioperative complications. Survival outcomes and tumor recurrence outcomes were similar among the approaches.ConclusionThe current approaches to cervical cancer surgery have comparable efficacies.
Inside Cover
Authors: Kong Yawei , Zhao Yinping , Yu Yao , Su Wenhua , Liu Zhijia , Fei Yiyan , Ma Jiong , Mi Lan 
Published: April 2022

The ability to sort yeast cells is important for diverse applications in the industry and research. We determined the aging level of yeast by the fluorescence lifetime imaging microscopy (FLIM) by an endogenous fluorophore NAD(P)H, which was label‐free and non‐invasive. Young and active yeast cells were sorted by the laser‐induced forward transfer (LIFT) system at the single cell level. The high viability of sorted cells was achieved.Further details can be found in the article by Yawei Kong, Yinping Zhao, Yao Yu, Wenhua Su, Zhijia Liu, Yiyan Fei, Jiong Ma, and Lan Mi (e202100344)
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Pattern analysis of the impact‐parameter dependent trajectories for the H + H2 exchange reaction at T = 3 and 300 K: A characteristic propensity for reactive versus nonreactive trajectories found in the time‐dependent interaction potential and a roaming‐like libration motion at cold temperature
Authors: Kasai Toshio , Muthiah Balaganesh , Po Xin‐Hui , Yan Chu‐Chun , Lin King‐Chuen , Tanudji Jeffrey , Diño Wilson Agerico 
Published: April 2022

AbstractPattern analysis of the impact‐parameter dependent trajectory for the H + H2 exchange reaction was performed at temperatures T = 3 and 300 K by employing the quasi‐classical trajectory calculation on a London‐Eyring‐Polanyi‐Sato surface. We find that (a) 0.66 fraction of reactive trajectories throughout b = 0.0 ~ 5.0 Å at T = 3 K, while only 0.33 at T = 300 K only for b = 0.0 ~ 1.5 Å and decreases soon to zero for b = 2.5 ~ 5.0 Å. (b) Ninety eight percent of the trajectories showed direct collision pattern at T = 300 K, while at T = 3 K, 72% for direct collision trajectories and 28% showed the intermediate H + H2 complex formation pattern. These results suggest that nonzero impact‐parameter trajectories play a role at T = 3 K to enhance reactivity due to long‐range attraction forces. Trajectory pattern analysis reveals a characteristic propensity rule between the amplitude of the time‐dependent interaction potential and the trajectory reactivity, thus we can judge if a trajectory is reactive or nonreactive. The analysis also proposes a roaming‐like libration motion at T = 3 K like in the interstellar clouds.
High purity (E)‐1,1,4,4‐tetramethyl‐2‐tetrazene synthesis, characterization, and properties: A hypergolic nontoxic prospective alternative to hydrazines
Authors: Huang Dan , Wang Huanchun , Wang Xuanjun , Sun Yubin , Du Yao , Gao Xin , Liu Xiang Xuan , Zuo Chunshan 
Published: April 2022

Abstract1,1,4,4‐Tetramethyl‐2‐tetrazene (TMTZ) as a hypergolic nontoxic prospective alternative was prepared and characterized by elemental analysis. The highest yield and purity can be obtained at the experimental parameters (UDMH/NH2Cl ratio 3:1; reaction time 20 min; extraction 15 min by ether, room temperature), in which the overall molar yield of TMTz is over 90%, with a purity up to 98.8%. The detailed synthesis mechanism was revealed by density functional theory methods (DFT). The high purity of TMTz can be explained by the intermediate diazene self react formed TMTz without energy barriers. The boiling point of TMTz is 135°C, which is higher than that of the MMH. It is hypergolic with green nitrous oxide. This study provides a feasible synthesis approach of high purity TMTz conducted at room temperature.
Linoleic‐acid‐substituted polyethylenimine to silence heat shock protein 90B1 (HSP90B1) to inhibit migration of breast cancer cells
Authors: Meenakshi Sundaram Daniel Nisakar , KC Remant Bahadur , Uludağ Hasan 
Published: April 2022

AbstractIntroductionBreast cancer continues to be one of the leading causes of death in women, and the lack of treatment options for distant metastasis warrants the need to identify and develop more effective approaches. The aim of this study was to identify and validate targets that are associated with the survival and migration of the breast cancer cells in vitro through RNA interference (RNAi) approach.MethodsLinoleic‐acid‐modified polyethylenimine (PEI) polymer was used to screen a short interfering RNA (siRNA) library against numerous cell adhesion and cytoskeleton genes in MDA‐MB‐231 triple‐negative breast cell line, and the functional outcome of silencing was determined by growth and migration inhibition with further target validation studies.ResultsHeat shock protein 90B1 (HSP90B1) was identified as a crucial gene that is known to be involved in various breast cancer machineries, including uncontrolled proliferation and brain metastasis. The success of this approach was also due to the use of hyaluronic acid (HA) additive in lipopolymer complexes that showed a profound impact in reducing the cell viability (~50%), migration (~40%), and mRNA transcript levels (~80%) with a physiologically relevant siRNA concentration of 60 nM. The use of Dicer‐substrate siRNA proved to be beneficial in target silencing, and a combinational treatment of integrin‐β1 (ITGB1) and HSP90B1 was effective in reducing the migration of the MDA‐MB‐231 and MDA‐MB‐436 breast cancer cells.ConclusionThis study demonstrates the potential to identify and silence targets using a lipid‐modified PEI/siRNA system and highlights the importance of HSP90B1 in the growth and migration of breast cancer cells.
Evaluation of water‐assisted UV‐C light and its additive effect with peracetic acid for the inactivation of Listeria monocytogenes, Salmonella enterica and murine norovirus on whole and fresh‐cut strawberries during shelf‐life
Authors: Ortiz‐Solà Jordi , Valero Antonio , Abadias Maribel , Nicolau‐Lapeña Iolanda , Viñas Inmaculada 
Published: April 2022

AbstractBACKGROUNDThe purpose of the present study was to examine the inactivation of Salmonella enterica (50 μL; 109 CFU g−1), Listeria monocytogenes (50 μL; 109 CFU g−1), and murine norovirus (MNV‐1; 50 μL; 107 50% tissue culture infectious dose (TCID50) mL−1) on whole and fresh‐cut strawberries after 2 min disinfection treatments (water (H2O), chlorine 200 mg L−1 (NaClO), water‐assisted ultraviolet‐C (UV‐C) (WUV), and the combination WUV and 40 mg L−1 of PA (WUV + PA)) in a water tank (15 L) equipped with 4 UV‐C lamps (17.2 W each), and after 7 days of cold storage (4 and 10 °C). For MNV‐1, dry UV‐C treatment (DUV) was also tested. For all UV‐C treatments, an irradiation dose of 1.3 kJ m−2 was used.RESULTSWhen strawberries were washed with WUV, L. monocytogenes and S. enterica were reduced by 2.8 and 2.2 log CFU g−1, respectively. The addition of 40 mg L−1 of PA to WUV (WUV + PA) increased the reduction range of L. monocytogenes and S. enterica by 1.9 and 0.8 log, respectively. Regarding the wash water, no pathogens were recovered after the WUV + PA treatment (detection limit 50 CFU mL−1). Depending on storage conditions (7 days at 4 or 10 °C), reductions observed were 0.5 to 2.0 log for S. enterica and 0.5 to 3.0 log for L. monocytogenes. The reductions in MNV‐1 titer after disinfection treatments ranged from 1.3 to 1.7 log. No significant differences between storage conditions were observed for MNV‐1: titers did not decline or were reduced up to 0.3 log after 7 days of cold storage.CONCLUSIONThe three‐way action for disinfecting strawberries by UV‐C irradiation and PA, plus the physical removal of the microorganisms by agitated water, are effective against foodborne pathogens on strawberries and water wash. During storage, WUV had a larger impact on the inactivation kinetics of S. enterica. Storage had little impact on MNV‐1 inactivation. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
On‐Chip Metamaterial Enabled Wavelength (De)Multiplexer
Authors: Zhao Yaotian , Xiang Jinlong , He Yu , Yin Yuchen , He An , Zhang Yong , Yang Zongyin , Guo Xuhan , Su Yikai 
Published: April 2022

AbstractWavelength‐division multiplexing (WDM) technology can offer considerable parallelism for large‐capacity data communications. While several configurations have been demonstrated to realize on‐chip WDM systems, their practical applications might be hindered by large footprints or compromised performances. Recently, metamaterial‐assisted silicon photonics is emerging for on‐chip light manipulation by subwavelength‐scale control of optical wavefronts. They can reach more compact footprints and broadband functionalities beyond the classical waveguide‐based architectures. Herein, wavelength (de)multiplexers are experimentally demonstrated in the subwavelength‐structured metamaterials regime with highly compact footprints. Two‐dimensional metamaterials composed of quasi‐periodic dielectric perturbation arrays patterned on a multimode waveguide are proposed to stimulate multiple high‐order waveguide modes at different wavelengths, which are then coupled to different WDM channels by cascading mode (de)multiplexers. The four‐channel wavelength (de)multiplexer is demonstrated in a box‐like spectrum with a compact footprint of 2.5 × 250 µm2, with the measured losses less than 2 dB and channel crosstalk less than –14.3 dB. By varying the patterned metamaterial structures, the proposed devices also have the merits of flexible operating wavelengths and bandwidths. The concept features large scalability, compactness, and competitive performance, which can offer versatile on‐chip light manipulation and significantly improve the integration density for various on‐chip WDM optical systems.
Trans‑10‑Hydroxy‑2‐Decenoic Acid Alleviates Dextran Sulfate Sodium‐Induced Colitis in Mice via Regulating the Inflammasome‐Mediated Pyroptotic Pathway and Enhancing Colonic Barrier Function
Authors: Huang Shanshan , Tao Ranran , Zhou Jiefei , Qian Linxi , Wu Jiang 
Published: April 2022

ScopeThe objective of this study is to explore the effects of 10‐hydroxy‐2‐decenoic acid (10‐HDA), the major fatty acid in royal jelly, on dextran sodium sulfate (DSS)‐induced mice ulcerative colitis (UC) and its potential mechanism of action.Methods and resultsForty male C57BL/6 mice are randomly divided into five experimental groups: control, DSS, DSS + 25 (or 100)mg kg−1 d−1 10‐HDA, and DSS + 200 mg kg−1 d−1 mesalazine (ME). UC is induced in mice using 2.5% DSS in drinking water for 7 days. During the induction, these UC mice are orally administrated 10‐HDA or ME per day. Meanwhile, lipopolysaccharide (LPS)/adenosine‐triphosphate (ATP)‐stimulated THP1 cells are used as a model to test the effects of 10‐HDA. 10‐HDA reduces DSS‐induced pathological damage, reactive oxygen species (ROS) accumulation, neutrophil infiltration, and cytokine production in colonic tissue. Compared with the DSS group, the expressions of thioredoxin interacting protein (TXNIP), NOD‐like receptor family pyrin domain containing 3 (NLRP3), apoptosis‐associated speck‐like protein containing a caspase‐recruitment domain (ASC), cysteinyl aspartate specific proteinase‐1 (Caspase‐1), gasdermin‐D (GSDMD), N‐terminal domain of gasdermin‐D (N‐GSDMD), interleukin‐1β (IL‐1β), and interleukin‐18 (IL‐18) in the colon are decreased after administration of 10‐HDA. 10‐HDA also elevates the barrier integrity and the expressions of zonula occludens‐1 (ZO‐1) and Occludin in colonic epithelium exposed to DSS. In THP1 cells, the inflammasome‐mediated pyroptosis induced by LPS/ATP is inhibited by 10‐HDA pretreatment.Conclusion10‐HDA alleviates DSS‐induced colitis by regulating the NLRP3 inflammasome‐mediated pyroptotic pathway and enhancing colonic barrier function.
Fluphenazine decanoate‐induced bradycardia: A case report
Authors: Kamali Mahsa , Zarghami Mehran , Azizi Marzieh , Elyasi Forouzan 
Published: April 2022

AbstractSinus tachycardia and orthostatic hypotension have been so far reported among the negative cardiovascular complications of antipsychotic agents. This study aimed to report a case with bradycardia induced by fluphenazine decanoate administration. The patient was a 29‐year‐old man, admitted to the general teaching hospital in Sari, Iran, with a complaint of abdominal and gastric pain as well as weight loss following 7 months of fasting based on religious delusions. The patient developed bradycardia, 36 hours after fluphenazine decanoate administration. His pulse rate was also 46 beats per min (bpm). The antipsychotic medication was thus held and the patient did not take any drugs. On the 21st day after discontinuing this agent, the pulse rate reached 70 bpm. This case report notifies that much more attention should be paid to all patients before starting fluphenazine decanoate administration, and close cardiac monitoring must be done.
Impact of hydroxyurea dose and adherence on hematologic outcomes for children with sickle cell anemia
Authors: Creary Susan E. , Beeman Chase , Stanek Joseph , King Kathryn , McGann Patrick T. , O'Brien Sarah H. , Liem Robert I. , Holl Jane , Badawy Sherif M. 
Published: April 2022

AbstractBackgroundHydroxyurea is the primary treatment for sickle cell anemia (SCA), yet real‐world implementation in high‐income settings is suboptimal. Variation in prescribed hydroxyurea dose and patient adherence in these settings can both affect actual exposure to hydroxyurea. Quantifying the contributions of hydroxyurea dose and medication adherence to the relationship between hydroxyurea exposure and hematologic parameters could inform strategies to optimize exposure and improve outcomes.ProcedureWe evaluated the relationship between hydroxyurea exposure, defined by average prescribed dose and adherence, and hematologic parameters using data from children with SCA who were enrolled in two prospective hydroxyurea adherence studies. Hydroxyurea adherence was assessed by video directly observed therapy or electronic pill bottle and medication administration record. Average prescribed dose was abstracted from prescriptions in patients’ electronic medical record. Participants with a hydroxyurea exposure >20 mg/kg/day and ≤20 mg/kg/day were included in the higher and lower exposure groups, respectively.ResultsForty‐five participants were included in the analysis (56% male; median age 12 years [range 2–19]; 98% Black). Higher exposed participants (n = 23) were prescribed a higher dose (27.2 vs. 24.4 mg/kg/day, p = .002) and had better adherence (0.92 vs. 0.71, p ≤ .001) compared to lower exposed participants (n = 22). Higher exposure was associated with higher fetal hemoglobin (p = .04) and mean corpuscular volume (p = .02).ConclusionsHigher hydroxyurea exposure is associated with improved hematologic parameters in the high‐income setting and is affected by both prescribed dose and adherence. Future studies are needed to optimize both adherence and hydroxyurea prescribing and confirm that increasing exposure improves clinical outcomes in this setting.