bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liver and heart failure: an ultrasound relationship
Authors: Lombardi Anna , Gambardella Michele , Palermi Stefano , Frecentese Francesca , Serio Alessandro , Sperlongano Simona , Tavarozzi Rita , D’andrea Antonello , De Luca Massimo , Politi Cecilia 
Published: September 2022

Abstract
Liver and heart are anatomically and patho-physiologically related. In heart failure (HF) the increased right atrial pressure and volume overload cause histological changes in hepatocytes, leading to a condition known as “congestive hepatopathy” (CH), with consequent variations in liver functioning and ultrasound (US) findings. CH has specifical US findings especially regarding venous vessels aspect, easily detecting by gray-scale study, but many others can be distinguished by Doppler analysis. Usually, hepatic veins look enlarged and hypocollassing, together with signs of portal hypertension (hepatomegaly, ascites, splenomegaly, porto-systemic collaterals). Typically, in CH Doppler findings regard alterations in venous vessel flow and arterial resistance (venous system hyperpulsatility, reduced velocity flow, high resistance index in hepatic arterial Doppler spectrum). Sometimes CH and other primary hepatopathy can coexist, and therefore some of the expected variations may not manifest: it allows suspecting an unknown underlying liver disease. At last, US technologies of more recent applications, even if not routinely used, allow investigating additional aspects such as elastography that detects changes in liver elasticity or contrastographic US, able to show differences in hepatic venous opacification. However, most of these US signs are not pathognomonic, and therefore a multidisciplinary clinical reasoning must not be lacking. The aim of the present review is to easily provide US signs of liver alterations in HF, in particular right heart failure with volume overload, suggesting including liver US in instrumental diagnosis and therapeutic monitoring of HF.
Association of environmental tobacco smoke (ETS) with lead and cadmium concentrations in biological samples of children and women: systematic review and meta-analysis
Authors: Rahmani Raouf , Nakhaee Samaneh , Sharafi Kiomars , Rezaei Zaynab , Mansouri Borhan , Amirabadizadeh Alireza 
Published: September 2022

Abstract

Objectives
Previous literature has shown that heavy metals (HMs) in cigarette smoke have been overestimated, and second-hand smoke (SHS) has recently raised public concern. This study aimed to review the effects of passive tobacco exposure on lead (Pb) and cadmium (Cd) concentrations of children and women in different biological samples.

Content
In this systematic review, two independent researchers assessed different databases/search engines including PubMed, Web of Science, Scopus, and Google Scholar using Mesh terms and Text Words. Studies between January 2000 and May 2022 were included. After quality assessment, studies with sufficient data were included in the meta-analysis. A fixed or random model was used to pool the results in a meta-analysis. Heterogeneity between the studies was assessed by using I-square and Q tests. Forest plots demonstrating the point and pooled estimates were provided.

Summary
A total of 976 studies were obtained from different databases and finally 17 studies meet our criteria and were included in our systematic review. Out of 17 studies, six studies had sufficient data for analysis and were included in the meta-analysis. The results of the meta-analysis showed a significant difference in blood lead concentrations (BLC) between the children with SHS exposure and the control group (Hedges’ g: 2.44, 95% CI: 1.01–3.86, p<0.05). Also, there were significant differences in hair levels of Cd (Hedges’ g: 0.66, 95% CI: 0.04, 1.28, p<0.05) and Pb (Hedges’ g: 0.94, 95% CI: 0.05, 1.83, p<0.05) between children with SHS exposure compared to the control group.

Outlook
The results of the present meta-analysis showed that passive smokers had higher Pb and Cd concentrations than those who were not exposed to cigarette smoke.
Progressively Decreased HCN1 Channels Results in Cone Morphological Defects in Diabetic Retinopathy
Authors: Han Ruyi , Jin Mengmeng , Xu Gezhi , He Jie 
Published: September 2022

Historically, diabetic retinopathy has been recognized as a vascular disease. Recent clinical evidence suggests the initiation of diabetic retinopathy with neuropathy rather than microangiopathy. However, the molecular mechanism that drives diabetic retinopathy-associated neuropathy remains mostly unexplored. Here, we reported progressive diabetic retinopathy defects in blood glucose levels, shortening of cone segments and uncoupled appearance of retinal vascular abnormalities frompdx1+/−mutantszebrafish to glucose-treatedpdx1+/−mutantszebrafish of both sexes. Further single-cell transcriptomic analysis revealed cones as the most vulnerable retinal neuron type that underwent three developmentally progressive cell states (States 1-3), predominantly present in WT animals,pdx1+/−mutants, and glucose-treatedpdx1+/−mutants, respectively. Mechanistically, the expression ofhcn1was progressively decreased in cones during its transition from State 1 to State 3. Furthermore, genetichcn1disruption resulted in similar cone segment defects found in the diabetic retinopathy model, suggesting the involvement of progressivehcn1reduction in diabetic retinopathy-associated cone defects. Thus, our study provided a vertebrate retina model representing progressive diabetic retinopathy defects and further gained new mechanistic insights into the cone morphologic defects as an early neuropathy in diabetic retinopathy.SIGNIFICANCE STATEMENTWe create a vertebrate retina model representing the progressive diabetic retinopathy-associated defects using zebrafish. Further systematic single-cell transcriptome analysis reveals two novel cell states of cones in response to different levels of higher glucose and the progressive decrease of HCN1 channels as a mechanism underlying cone defects in diabetic retinopathy.
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation
Authors: Peter Joshua J , Magnussen Helge M , DaRosa Paul A , Millrine David , Matthews Stephen P , Lamoliatte Frederic , Sundaramoorthy Ramasubramanian , Kopito Ron R , Kulathu Yogesh 
Published: September 2022

AbstractProtein UFMylation, i.e., post‐translational modification with ubiquitin‐fold modifier 1 (UFM1), is essential for cellular and endoplasmic reticulum homeostasis. Despite its biological importance, we have a poor understanding of how UFM1 is conjugated onto substrates. Here, we use a rebuilding approach to define the minimal requirements of protein UFMylation. We find that the reported cognate E3 ligase UFL1 is inactive on its own and instead requires the adaptor protein UFBP1 to form an active E3 ligase complex. Structure predictions suggest the UFL1/UFBP1 complex to be made up of winged helix (WH) domain repeats. We show that UFL1/UFBP1 utilizes a scaffold‐type E3 ligase mechanism that activates the UFM1‐conjugating E2 enzyme, UFC1, for aminolysis. Further, we characterize a second adaptor protein CDK5RAP3 that binds to and forms an integral part of the ligase complex. Unexpectedly, we find that CDK5RAP3 inhibits UFL1/UFBP1 ligase activity in vitro. Results from reconstituting ribosome UFMylation suggest that CDK5RAP3 functions as a substrate adaptor that directs UFMylation to the ribosomal protein RPL26. In summary, our reconstitution approach reveals the biochemical basis of UFMylation and regulatory principles of this atypical E3 ligase complex.
Tauhid View Tuan Guru Umar Kelayu: Intellectual History Study of Lombok Theologian Central Figure
Authors: Tohri Ahmad , Rasyad Abdul , Habibuddin Habibuddin , Zulkarnain Zulkarnain 
Published: September 2022

Tuan Guru Umar Kelayu (TGU) was one of the pioneers and a central figure born in the era of the teacher-teaching of the Sasak-Lombok community. The purpose of this study is to analyze the monotheistic view of TGU as the central figure of Lombok clerics in the study of intellectual history. The research method used is the historical method, which is a process of critically analyzing records and experiences or relics of the past. The results showed that TGU as a teacher early generation was born from a family that has a breed very strong with the Islamic Selaparang Kingdom by mastering religious knowledge broadly and deeply which was obtained from scholars in Lombok, the archipelago, and the world. The wisdom of TGU is reflected in the book of monotheism written at the age of ± 25 years, with the title Manzarul Amrad. The systematic thinking, perspective, and narrative style are unique in writing the book of monotheism that distinguishes it from other scholars. The monotheistic view of TGU has an impact on strengthening Islam, especially strengthening the faith of the Sasak-Islamic community. Instilling the spirit of jihad fi sabilillah, the Sasak people fought against the Balinese and Dutch rulers. TGU is involved in the dialectic of Islamic intellectuals through a network of teachers, friends, and students in Lombok, the archipelago, and even the Islamic world.Tuan Guru Umar Kelayu (TGU) merupakan salah seorang perintis dan tokoh sentral kelahiran era ke-tuan guru-an masyarakat Sasak-Lombok. Tujuan penelitian menganalisis pandangan tauhid TGU sebagai tokoh sentral ulama Lombok dalam kajian sejarah intelektual. Metode penelitian yang digunakan metode sejarah, yaitu suatu proses menganalisis secara kritis rekaman dan pengalaman atau peninggalan masa lampau. Hasil penelitian menunjukkan TGU sebagai tuan guru generasi awal terlahir dari keluarga yang memiliki trah sangat kuat dengan Kerajaan Selaparang Islam dengan menguasai ilmu agama secara luas dan mendalam yang diperoleh dari para ulama di Lombok, Nusantara, dan dunia. Kealiman TGU tercermin dari kitab tauhid ditulis pada usia ±25 tahun, dengan judul Manzarul Amrad. Sistematika berpikir, cara pandang, dan gaya narasi merupakan keunikan dalam menulis kitab tauhid yang membedakannya dengan ulama-ulama lain. Pandangan tauhid TGU berdampak terhadap penguatan keislaman terutama peneguhan akidah masyarakat Islam-Sasak. Menanamkan semangat jihad fi sabilillah rakyat Sasak melakukan perlawanan pada penguasa Bali dan Belanda. TGU terlibat dalam dialektika intelektual keislaman melalui jaringan guru, sahabat, dan murid di Lombok, Nusantara, bahkan dunia Islam.Cite this article: Tohri, A., Rasyad, A. Habibuddin, Zulkarnain (2022). Tauhid View Tuan Guru Umar Kelayu: Intellectual History Study of Lombok Theologian Central Figure. Paramita: Historical Studies Journal, 32(1), 1-10. http://dx.doi.org/10.15294/paramita.v32i1.26636
Whispers from The Forest, Local wisdom in forest conservation and utilization
Authors: Witasari Nina 
Published: September 2022

Forest utilization and conservation have become a serious problem faced by many countries in the world. Forests in Java have been exploited massively since colonial rule. Exploitation not only by the colonial government but also by the indigenous rulers. Of course, this exploitation has a big impact on the ecology of Java's forests, which then experience a decline in quality and the loss of several forest areas. Behind all the chaos that occurs in forest management in Java, people instinctively have a mechanism to manage and preserve the forest where they live and make a living. The mechanism in question is to use traditions and myths that have grown and developed in society. This research is social history research, which explores the historical sources of Javanese forestry and relates to social changes that occur in society. The method used is the historical research method and is equipped with information obtained from interviews with some informants. From the results of the research conducted, it can be seen that the Javanese people, especially those who still live around the forest, are currently carrying out traditions related to forest maintenance. Although the forest area is shrinking, the tradition is still carried out, for reasons of cultural and economic preservation.Pemanfaatan dan konservasi hutan telah menjadi masalah serius yang dihadapi oleh banyak negara di dunia. Hutan di Jawa telah dieksploitasi secara besar-besaran sejak pemerintahan kolonial. Eksploitasi tidak hanya dilakukan oleh pemerintah kolonial tetapi juga oleh penguasa pribumi. Tentu saja eksploitasi ini berdampak besar terhadap ekologi hutan Jawa yang kemudian mengalami penurunan kualitas dan hilangnya beberapa kawasan hutan. Di balik semua kekacauan yang terjadi dalam pengelolaan hutan di Jawa, masyarakat secara naluriah memiliki mekanisme untuk mengelola dan melestarikan hutan tempat mereka hidup dan mencari nafkah. Mekanisme yang dimaksud adalah dengan menggunakan tradisi dan mitos yang telah tumbuh dan berkembang di masyarakat. Penelitian ini merupakan penelitian sejarah sosial, yang menggali sumber-sumber sejarah kehutanan Jawa dan berkaitan dengan perubahan sosial yang terjadi di masyarakat. Metode yang digunakan adalah metode penelitian sejarah dan dilengkapi dengan informasi yang diperoleh dari wawancara dengan beberapa informan. Dari hasil penelitian yang dilakukan dapat diketahui bahwa masyarakat Jawa khususnya yang masih tinggal di sekitar hutan saat ini menjalankan tradisi yang berkaitan dengan pemeliharaan hutan. Meski luas hutan semakin menyusut, tradisi tersebut tetap dilakukan, dengan alasan pelestarian budaya dan ekonomi.Cite this article: Witasari, N. (2022). Whispers from the Forest: Local Wisdom in forest Conservation and Utilization. Paramita: Historical Studies Journal, 32(1), 23-32. http://dx.doi.org/10.15294/paramita.v32i1.27173
The Historical Narrative for Indonesia as A Multiethnic State: A Methodological Exploration
Authors: Purwanta Hieronymus 
Published: September 2022

This study aims to analyze Indonesian historiography for education from a methodological perspective. The main problem raised was what historical narratives are suitable for the Indonesia as a multiethnic state? This research analyzes the historiography for education published along the New Order period (1967-1998) to the Reformation era (1998-now). The approach used was hermeneutic developed by Heidegger and Gadamer. They view that an audience is a crucial person in interpreting historical narrative. The historiographical study results indicate that the historical narrative developed did not represent objective, deterministic, and monolithic. This study not only criticized the Indonesian history narrative that was published but also offered the use of Inter-Ethnics Relations and 'History from within' approach as the solution. The inter-Ethnics Relations approach highlights the intensity of positive interactions between ethnics to eliminate prejudice and conflict. On the other hand, history from within approach makes historical events understood as representations of the socio-cultural system. Historical action is interpreted and understood as an effort to realize the ideal life order under historical actors' values and culture. Through these two approaches, the historical narrative makes sense for people from all ethnicities as citizens of the Indonesia.Penelitian ini bertujuan untuk menganalisis historiografi Indonesia untuk pendidikan dari perspektif metodologis. Masalah utama yang diangkat adalah narasi sejarah apa yang cocok untuk Indonesia sebagai negara multietnis? Penelitian ini menganalisis historiografi pendidikan yang diterbitkan pada masa Orde Baru (1967-1998) hingga era Reformasi (1998-sekarang). Pendekatan yang digunakan adalah hermeneutik yang dikembangkan oleh Heidegger dan Gadamer. Mereka memandang bahwa penonton adalah orang yang sangat penting dalam menafsirkan narasi sejarah. Hasil kajian historiografis menunjukkan bahwa narasi sejarah yang dikembangkan tidak merepresentasikan objektif, deterministik, dan monolitik. Kajian ini tidak hanya mengkritisi narasi sejarah Indonesia yang diterbitkan tetapi juga menawarkan penggunaan Hubungan Antar Etnis dan pendekatan 'Sejarah dari dalam' sebagai solusinya. Pendekatan Hubungan Antar Etnis menyoroti intensitas interaksi positif antar etnis untuk menghilangkan prasangka dan konflik. Di sisi lain, pendekatan sejarah dari dalam membuat peristiwa sejarah dipahami sebagai representasi dari sistem sosial budaya. Tindakan sejarah dimaknai dan dipahami sebagai upaya mewujudkan tatanan kehidupan yang ideal di bawah nilai dan budaya pelaku sejarah. Melalui dua pendekatan ini, narasi sejarah masuk akal bagi orang-orang dari semua etnis sebagai warga negara Indonesia.Cite this article: Purwanta, H. (2022). The Historical Narrative for Indonesia as A Multiethnic State: A Methodological Exploration. Paramita: Historical Studies Journal, 32(1), 117-126. http://dx.doi.org/10.15294/paramita.v32i1.31124
Reconstructing the History of Jatropha Introduction and Commoditization in Indonesia
Authors: Widjaja Henky 
Published: September 2022

This article discusses the history of jatropha in Indonesia, an oil producing plant, which was praised globally as a miracle crop in the first decade of 2000s. After its recent global failure, scientists started to acknowledge the existing insufficient knowledge about this crop. While many current studies on jatropha are focusing on the agronomic, socio-economic and technical aspects of this plant, little effort has been dedicated to explore its historical aspect. This article will specifically contribute to address the absence of clear historical reconstruction of jatropha in Indonesia. The reconstruction is important to present the actual history of the past regarding the cultivation and the application of jatropha. This article addresses the following questions: Have the cultivation and application of jatropha curcas as biofuel been taken place since the Japanese administration period in Indonesia? If not, what was the actual history of biofuel crop cultivation and application at that period of time? How did the popular claims on jatropha history link to the creation of Jatropha hype? The answers of the questions are essential to understand why until today little experiences, knowledge and technologies are available on the ground for both jatropha cultivation and oil processing either at the farm level and industrial scale.Artikel ini membahas tentang sejarah jarak pagar di Indonesia, tanaman penghasil minyak yang dipuji secara global sebagai tanaman ajaib pada dekade pertama tahun 2000-an. Setelah kegagalan global baru-baru ini, para ilmuwan mulai mengakui kurangnya pengetahuan yang ada tentang tanaman ini. Sementara banyak penelitian terkini tentang jarak yang berfokus pada aspek agronomi, sosial-ekonomi dan teknis tanaman ini, sedikit upaya telah didedikasikan untuk mengeksplorasi aspek sejarahnya. Artikel ini secara khusus akan memberikan kontribusi untuk menjawab tidak adanya rekonstruksi sejarah jarak pagar yang jelas di Indonesia. Rekonstruksi ini penting untuk menyajikan sejarah aktual masa lalu mengenai budidaya dan penerapan jarak pagar. Artikel ini menjawab pertanyaan-pertanyaan berikut: Apakah budidaya dan penerapan jarak pagar sebagai bahan bakar nabati sudah dilakukan sejak masa pemerintahan Jepang di Indonesia? Jika tidak, bagaimana sebenarnya sejarah budidaya dan aplikasi tanaman biofuel pada periode tersebut? Bagaimana klaim populer tentang sejarah jarak pagar terkait dengan penciptaan hype jarak pagar? Jawaban dari pertanyaan-pertanyaan tersebut sangat penting untuk memahami mengapa sampai saat ini hanya sedikit pengalaman, pengetahuan dan teknologi yang tersedia di lapangan baik untuk budidaya jarak pagar maupun pengolahan minyak baik di tingkat petani maupun skala industri.Cite this article: Widjaja, H. (2022). Reconstructing the History of Jatropha Introduction and Commoditization in Indonesia. Paramita: Historical Studies Journal, 32(1), 57-66. http://dx.doi.org/10.15294/paramita.v32i1.31277
Urban Sanitation Problems and the Efforts to Overcome it in Medan City, 1909-1930s
Authors: Affandi Kiki Maulana , Agustono Budi , Zuska Fikarwin 
Published: September 2022

The growth of the city of Medan since the end of the 19th century had not only shown changes in terms of city infrastructure but also caused problems of urban sanitation such as slum settlements, industrial and household waste as well as river pollution. This study aims to explain sanitation problems in Medan City and the efforts to overcome them. This study used historical methods consisting of heuristics, source criticism, interpretation, and historiography. The sources used are archives, documents, city reports, city sheets, meeting minutes, contemporary newspapers, and other sources relevant to this study. The results show that the city's sanitation problems are caused by the habits of residents, plantation companies and institutions in the city government itself. These various sanitation problems were solved by developing urban sanitation despite having a limited city budget. This city sanitation development effort was focused on the aspects of public bathroom projects for the natives and the construction of a sewer system.Pertumbuhan Kota Medan sejak akhir abad 19 memperlihatkan perubahan dari sisi prasarana kota namun juga memberikan permasalahan sanitasi kota seperti permukiman kumuh, limbah industri dan rumah tangga serta pencemaran sungai. Studi ini bertujuan untuk menjelaskan permasalahan sanitasi di Kota Medan dan upaya penanggulangan yang dilakukan. Penelitian ini menggunakan metode sejarah yang terdiri dari heuristik, kritik sumber, interpretasi, dan historiografi. Sumber-sumber yang digunakan adalah arsip, dokumen, laporan kota, lembaran kota, notulen rapat, surat kabar sezaman, dan sumber lain yang relevan dengan studi ini. Hasil penelitian diperoleh bahwa masalah sanitasi kota disebabkan oleh kebiasaan penduduk, perusahaan perkebunan dan institusi pada pemerintah kota itu sendiri. Berbagai permasalahan sanitasi tersebut diatasi dengan membangun sanitasi kota meskipun memiliki anggaran kota yang terbatas. Usaha pembangunan sanitasi kota ini memperlihatkan konsentrasi dan kepedulian dalam bidang proyek kamar mandi umum bagi penduduk bumiputra dan pembangunan sistem saluran pembuangan limbah kota.Cite this article: Affandi, K.M., Agustono, B., Zuska, F. (2022). Urban Sanitation Problems and the Efforts to Overcome It in Medan City, 1909–1930s. Paramita: Historical Studies Journal, 32(1), 45-56. http://dx.doi.org/10.15294/paramita.v32i1.31353