bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomic profiling analysis to identify genes associated with PA biosynthesis and insolubilization in the late stage of fruit development in C-PCNA persimmon
Authors: Wang Yiru , Zhang Qi , Pu Tingting , Suo Yujing , Han Weijuan , Diao Songfeng , Li Huawei , Sun Peng , Fu Jianmin 
Published: November 2022

AbstractPA-enhanced content causes astringency in persimmon fruit. PCNA persimmons can lose their astringency naturally and they become edible when still on the tree, which allows for conserves of physical and financial resources. C-PCNA persimmon originates in China. Its deastringency trait primarily depends on decreased PA biosynthesis and PA insolubilization at the late stage of fruit development. Although some genes and transcription factors that may be involved in the deastringency of C-PCNA persimmon have been reported, the expression patterns of these genes during the key deastringency stage are reported less. To investigate the variation in PA contents and the expression patterns of deastringency-related genes during typical C-PCNA persimmon ‘Xiaoguo-tianshi’ fruit development and ripening, PA content and transcriptional profiling were carried out at five late stages from 70 to 160 DAF. The combinational analysis phenotype, PA content, and DEG enrichment revealed that 120–140 DAF and 140–160 DAF were the critical phases for PA biosynthesis reduction and PA insolubilization, respectively. The expression of PA biosynthesis-associated genes indicated that the downregulation of the ANR gene at 140–160 DAF may be associated with PA biosynthesis and is decreased by inhibiting its precursor cis-flavan-3-ols. We also found that a decrease in acetaldehyde metabolism-associated ALDH genes and an increase in ADH and PDC genes might result in C-PCNA persimmon PA insolubilization. In addition, a few MYB-bHLH-WD40 (MBW) homologous transcription factors in persimmon might play important roles in persimmon PA accumulation. Furthermore, combined coexpression network analysis and phylogenetic analysis of MBW suggested that three putative transcription factors WD40 (evm.TU.contig1.155), MYB (evm.TU.contig8910.486) and bHLH (evm.TU.contig1398.203), might connect and co-regulate both PA biosynthesis and its insolubilization in C-PCNA persimmon. The present study elucidated transcriptional insights into PA biosynthesis and insolubilization during the late development stages based on the C-PCNA D. kaki genome (unpublished). Thus, we focused on PA content variation and the expression patterns of genes involved in PA biosynthesis and insolubilization. Our work has provided additional evidence on previous knowledge and a basis for further exploration of the natural deastringency of C-PCNA persimmon.
Involvement of the calcitonin gene-related peptide system in the modulation of inflamed uterus contractile function in pigs
Authors: Jana Barbara , Całka Jarosław , Sikora Małgorzata , Palus Katarzyna 
Published: November 2022

AbstractThis study analyzed severe acute endometritis action on myometrial density and distribution of protein gene product (PGP)9.5- and calcitonin gene-related peptide (CGRP)-like immunoreactive nerve fibers and calcitonin receptor-like receptor (CLR) expression, and on CGRP receptor (CGRPR) participation in uterine contractility in pigs. E. coli suspension (E. coli group) or saline (SAL group) were injected into the uteri, or only laparotomy was performed (CON group). In the E. coli group myometrium, a lack of significant changes in PGP9.5 and CGRP innervation patterns and increased CLR protein level were revealed. In all groups, compared to the pretreatment period, human αCGRP increased amplitude in the myometrium, while reducing it in endometrium/myometrium. In the E. coli group endometrium/myometrium, human αCGRP lowered amplitude vs other groups. Human αCGRP reduced frequency in CON and SAL groups and enhanced it in the E. coli group endometrium/myometrium. The frequency in E. coli group increased vs other groups. CGRPR antagonist, human αCGRP8–37, reversed (CON, SAL groups) and eliminated (E. coli group) the rise in human αCGRP-induced myometrial amplitude. In endometrium/myometrium, human αCGRP8–37 abolished (CON group) and reversed (SAL group) a decrease in frequency, and reduced the rise in frequency (E. coli group) caused by human αCGRP. Collectively, in the myometrium, endometritis did not change PGP9.5 and CGRP innervation patterns and enhanced CLR protein level. CGRPR also mediated in CGRP action on inflamed uterus contractility.
Associations of decayed teeth and localized periodontitis with mental stress in young adults: CHIEF oral health study
Authors: Tsai Kun-Zhe , Tsai Sung-Chiao , Lin Ko-Huan , Chang Yun-Chen , Lin Yen-Po , Lin Gen-Min 
Published: November 2022

AbstractThe associations of mental stress with decayed teeth in children and periodontitis in old-aged adults have been described. However, the associations for young adults were not clear. This study aimed to examine the associations of decayed teeth and localized periodontitis with mental stress in young adults. This study included 334 military recruiters, aged 19–45 years in Taiwan. Mental stress was assessed by the brief symptom rating scale-5 (BSRS-5), including five domains: anxiety, depression, hostility, interpersonal sensitivity and insomnia (maximum score of 20). Those with symptomatic mental stress were defined as having BSRS-5 > 5 (n = 34). Multiple linear and logistic regression models were used to determine the associations of decayed tooth numbers and periodontitis with BSRS-5, with adjustments for age, sex, education level, physical activity, body weight category and smoking status. The BSRS-5 was positively correlated with decayed tooth numbers [β: 0.26 (95% confidence interval: 0.01–0.52)]. Those who had more than two decayed teeth [odds ratio: 3.59 (1.52–8.46)] had a higher risk of symptomatic mental stress. In contrast, the correlation between BSRS-5 and localized severer periodontitis was null. Our study recommended that decayed teeth instead of localized periodontitis, was a risk factor for mental stress in young adults.
A genome-wide association study with tissue transcriptomics identifies genetic drivers for classic bladder exstrophy
Authors: Mingardo Enrico , Beaman Glenda , Grote Philip , Nordenskjöld Agneta , Newman William , Woolf Adrian S. , Eckstein Markus , Hilger Alina C. , Dworschak Gabriel C. , Rösch Wolfgang , Ebert Anne-Karolin , Stein Raimund , Brusco Alfredo , Di Grazia Massimo , Tamer Ali , Torres Federico M. , Hernandez Jose L. , Erben Philipp , Maj Carlo , Olmos Jose M. , Riancho Jose A. , Valero Carmen , Hostettler Isabel C. , Houlden Henry , Werring David J. , Schumacher Johannes , Gehlen Jan , Giel Ann-Sophie , Buerfent Benedikt C. , Arkani Samara , Åkesson Elisabeth , Rotstein Emilia , Ludwig Michael , Holmdahl Gundela , Giorgio Elisa , Berettini Alfredo , Keene David , Cervellione Raimondo M. , Younsi Nina , Ortlieb Melissa , Oswald Josef , Haid Bernhard , Promm Martin , Neissner Claudia , Hirsch Karin , Stehr Maximilian , Schäfer Frank-Mattias , Schmiedeke Eberhard , Boemers Thomas M. , van Rooij Iris A. L. M. , Feitz Wouter F. J. , Marcelis Carlo L. M. , Lacher Martin , Nelson Jana , Ure Benno , Fortmann Caroline , Gale Daniel P. , Chan Melanie M. Y. , Ludwig Kerstin U. , Nöthen Markus M. , Heilmann Stefanie , Zwink Nadine , Jenetzky Ekkehart , Odermatt Benjamin , Knapp Michael , Reutter Heiko 
Published: November 2022

AbstractClassic bladder exstrophy represents the most severe end of all human congenital anomalies of the kidney and urinary tract and is associated with bladder cancer susceptibility. Previous genetic studies identified one locus to be involved in classic bladder exstrophy, but were limited to a restrict number of cohort. Here we show the largest classic bladder exstrophy genome-wide association analysis to date where we identify eight genome-wide significant loci, seven of which are novel. In these regions reside ten coding and four non-coding genes. Among the coding genes is EFNA1, strongly expressed in mouse embryonic genital tubercle, urethra, and primitive bladder. Re-sequence of EFNA1 in the investigated classic bladder exstrophy cohort of our study displays an enrichment of rare protein altering variants. We show that all coding genes are expressed and/or significantly regulated in both mouse and human embryonic developmental bladder stages. Furthermore, nine of the coding genes residing in the regions of genome-wide significance are differentially expressed in bladder cancers. Our data suggest genetic drivers for classic bladder exstrophy, as well as a possible role for these drivers to relevant bladder cancer susceptibility.
Mechanism investigation of fermented egg-milk peptides on colonic inflammatory diseases: based on in vivo and in silico research
Authors: Lyu Siwen , Yang Qi , Li Ting , Duan Xuehui , Liu Jingbo , Pan Fengguang , Yu Yiding , Zhang Ting 
Published: November 2022

Mechanism investigation of fermented egg-milk peptides on colonic inflammatory diseases: based on in vivo and in silico research.
Potential roles of hyaluronic acid in in vivo CAR T cell reprogramming for cancer immunotherapy
Authors: Laomeephol Chavee , Areecheewakul Sudartip , Tawinwung Supannikar , Suppipat Koramit , Chunhacha Preedakorn , Neves Nuno M. , Luckanagul Jittima Amie 
Published: November 2022

Hyaluronic acid-based nanoparticles can be promising tools for gene delivery in in vivo reprogramming CAR T cells, as well-designed carriers are needed for targeting and transducing circulating T cells.
Readability of Individuals With Disabilities Education Act Part B Procedural Safeguards Notices Written in Spanish
Authors: Quintero Stella , Zraick Richard I. , Rosa-Lugo Linda I. , La Scala Jennifer D. 
Published: November 2022

Purpose:
The purpose of this study was to analyze the readability of the Individuals with Disabilities Education Act (IDEA) Part B procedural safeguard notices written in Spanish, as distributed by each of the 50 states in the United States and the District of Columbia. Results were compared with the 6th–8th grade document readability guideline recommended by experts in health communication.

Method:
A commercially available readability software program was used to assess document readability using three readability indices: the Gilliam–Peña–Mountain Graph, SOL, and the Fry Readability Adaptation for Spanish Evaluation.

Results:
All procedural safeguard notices were written at a reading grade level greater than established guidelines. This finding agrees with research that has examined the readability of English-language versions of IDEA Part B procedural safeguard notices.

Conclusions:
Literacy-related skills and demands may influence the ability of the parent to advocate on behalf of his or her child with a disability within the school setting. Educators and specialists should be sensitive to parent reading preferences and proficiency when reviewing IDEA procedural safeguards notices. Authors of procedural safeguard notices should account for the native language and culture of the intended reader as revisions to, and translations are made of, IDEA procedural safeguards notices.
Inner Speech and Executive Function in Children With Developmental Language Disorder: Implications for Assessment and Intervention
Authors: Baron Lauren S. , Arbel Yael 
Published: November 2022

Purpose:
Many children with developmental language disorder (DLD) also have difficulty with executive function. The presence of co-occurring deficits in language and executive function can obscure assessment results and lead to the implementation of ineffective interventions. It is also the case that inner speech, or the use of self-directed language to guide thought and action, often mediates performance on executive function tasks. The aims of this tutorial are to (a) summarize what is known about how inner speech affects executive function performance in typical populations and children with DLD and (b) highlight potential implications for clinical practice and directions for future research. We provide a brief background on inner speech, including theoretical frameworks, typical development, and measurement approaches. We then summarize research on inner speech and executive function involving typical adults and children, followed by a description of the few studies involving children with DLD.

Conclusions:
Work with typical adults and children has concluded that inner speech operates as a self-cueing device to support understanding of task rules, sequencing of task order, and maintenance of task goals. Work involving children with DLD suggests that their inner speech is less mature, less relevant, and less effective overall when completing executive function tasks. However, very few studies have examined the relations between inner speech and executive function in children with DLD. It is important for speech-language pathologists to understand the potential role of inner speech during executive function tasks, given how often these skills are utilized during everyday activities. Although more research is needed, speech-language pathologists are in a unique position to support both language and executive function goals for children with DLD.
Aggregation operators and CRITIC‐VIKOR method for confidence complex q‐rung orthopair normal fuzzy information and their applications
Authors: Mahmood Tahir , Ali Zeeshan , Naeem Muhammad 
Published: November 2022

AbstractSupply chain management is an essential part of an organisation's sustainable programme. Understanding the concentration of natural environment, public, and economic influence and feasibility of your suppliers and purchasers is becoming progressively familiar as all industries are moving towards a massive sustainable potential. To handle such sort of developments in supply chain management the involvement of fuzzy settings and their generalisations is playing an important role. Keeping in mind this role, the aim of this study is to analyse the role and involvement of complex q‐rung orthopair normal fuzzy (CQRONF) information in supply chain management. The major impact of this theory is to analyse the notion of confidence CQRONF weighted averaging, confidence CQRONF ordered weighted averaging, confidence CQRONF hybrid averaging, confidence CQRONF weighted geometric, confidence CQRONF ordered weighted geometric, confidence CQRONF hybrid geometric operators and try to diagnose various properties and results. Furthermore, with the help of the CRITIC and VIKOR models, we diagnosed the novel theory of the CQRONF‐CRITIC‐VIKOR model to check the sensitivity analysis of the initiated method. Moreover, in the availability of diagnosed operators, we constructed a multi‐attribute decision‐making tool for finding a beneficial sustainable supplier to handle complex dilemmas. Finally, the initiated operator's efficiency is proved by comparative analysis.
A lightweight encryption and message authentication framework for wireless communication
Authors: Wang Shaoyu , Huang Kaizhi , Ma Keming , Xu Xiaoming , Hu Xiaoyan 
Published: November 2022

AbstractConfidentiality and authentication are two important security properties of wireless communication. There are currently two types of research in wireless communication security: one is based on cryptography, which can be too complicated for some wireless systems; the other is based on physical layer characteristics, which has some security problems and cannot work as well as the cryptography‐based method. In this paper, a lightweight encryption and message authentication framework for wireless communication is proposed. The proposed framework has lower complexity than the cryptography‐based method and works more securely and efficiently than the classical physical layer method. For the encryption, a physical layer offered chain key (PHYLOCK) structure is proposed to generate one‐time keys, which are then XOR‐ed with the plaintext to generate the ciphertext. A security analysis of PHYLOCK is performed and it is proved that it has better security features than the traditional physical layer key generation. For the message authentication, three types of PHYLOCK‐CRC‐based message authentication schemes are developed whose generator polynomial is determined by one‐time keys generated by PHYLOCK. PHYLOCK‐CRC‐based message authentication detects not only random errors introduced by noises but also malicious attacks. The error‐detecting and anti‐attack capabilities are analyzed mathematically. Compared to the standard CRC, PHYLOCK‐CRC‐based message authentication has a decline in error correction capability but is enhanced with cryptographic security features. Monte‐Carlo simulations are provided to evaluate the proposed scheme.
High‐frequency k‐mer counting at low memory footprint
Authors: Mocheng Li , Yang Liu , Nong Xiao , Zhiguang Chen 
Published: November 2022

AbstractGenomics data analysis requires efficient tools to address the vast amount of data generated by current next‐generation sequencing technologies. K‐mer counting works face difficulties in balancing high memory overhead with statistical precision. We designed a high‐frequency k‐mer statistical computation based on the Space Saving algorithm and a novel hash table structure, which reduces the memory overhead by 46% while ensuring high computational efficiency.
Research on error self‐correction complementary non‐zero vector pulse width modulation strategy
Authors: Shen Yongpeng , Wu Kexuan , Xiao Yanqiu , Liang Weihua , Wang Qian 
Published: November 2022

AbstractThe DC link single sensor phase current reconstruction method has brought several challenges, which consist of the unobservable area and current zero drift error, where the duration of the effective vector is too short to measure, and current zero drift error leads to reconstruction error. An error self‐correction complementary non‐zero vector pulse width modulation (ESC2N‐PWM) method is proposed. Through the analysis of the DC link sampling principle, the minimum sample time is defined. Then applying complementary non‐zero vectors to replace zero voltage vector, the current sampling window is extended, and the sector boundary unobservable area is eliminated. At the same time, through the dynamic double sampling of the complementary effective voltage vectors, the zero drift of current is self‐detected and self‐corrected. The experimental results show that the reconstruction error of the proposed method is lower than 2.84%, and the current THD is lower than 6.20%.
Research on photovoltaic energy storage micro‐grid systems based on improved sliding mode control
Authors: Fu Changxin , Zhang Lixin , Li Huaisheng 
Published: November 2022

AbstractIn islanded microgrid systems, PV power generation efficiency and energy loss of storage battery are the current research trends. Due to the intermittent and fluctuating characteristics of PV power generation, various loads connected to the DC microgrid system would also bring DC bus voltage low‐frequency fluctuations and other problems. In order to solve the above problems, an maximum power point tracking (MPPT) tracking strategy (sliding mode control based on squirrel search algorithm) is proposed in this study; meanwhile, a sliding mode control strategy based on an improved reaching law is designed. The components of the PV energy storage system and the control method are mainly focused on, and the PV energy storage system is optimized by improving the sliding mode control. The proposed control algorithm is verified and analyzed by MATLAB/Simulink simulation platform. Compared with the double integral sliding mode control algorithm MPPT tracking case, sliding mode control based on squirrel search algorithm shows excellent performance (short response time, good tracking maximum power point effect etc.). In addition, the sliding mode control based on the proposed reaching law reduces the system jitter, and effectively reduces jitter and vibration of the PV energy storage battery.
An MILP model for risk‐based placement of RCSs, DDGs, and tie lines in distribution systems with complex topologies
Authors: Zare‐Bahramabadi Majid , Farzin Hossein , Ehsan Mehdi 
Published: November 2022

AbstractRemote‐controlled switches (RCSs) have the ability to quickly isolate the faulted area from other parts of distribution systems. On the other hand, the distributed generation resources (DGs) and tie lines can supply the interrupted loads after fault occurrence as a microgrid. In this regard, this paper proposes a planning model for simultaneous placement of RCSs, dispatchable DGs (DDGs), and tie lines in distribution systems with complex topologies to improve their reliability. Presence of renewable DGs (RDGs) including photovoltaic cells (PVs) and wind turbines (WTs), as well as the uncertainties of loads, RDGs, and outage duration of the faulted areas are also considered in the proposed planning model. Conditional value at risk (CVaR) is used to manage the system risk. The proposed planning model is formulated as a mixed integer linear programming model (MILP), which can be solved using various commercial solvers and give the global optimal solution. Finally, the proposed planning model is implemented on the IEEE 33 bus system as various cases to illustrate its effectiveness on improving the reliability of distribution systems and managing the system risk.
Fühler‐im‐Netz: A smart grid and power line communication data set
Authors: Balada Christoph , Ahmed Sheraz , Dengel Andreas , Bondorf Max , Hopfer Nikolai , Zdrallek Markus 
Published: November 2022

AbstractThe increasing complexity of low‐voltage networks poses a growing challenge for the reliable and fail‐safe operation of electricity grids. The reasons for this include an increasingly decentralised energy generation (photovoltaic systems, wind power etc.) and the emergence of new types of consumers (e‐mobility, domestic electricity storage etc.). At the same time, the low‐voltage grid is largely unmonitored and local power failures are sometimes hard to detect. To overcome this, power line communication (PLC) has emerged as a potential solution for reliable monitoring of the low‐voltage grid. In addition to establishing a communication infrastructure, PLC also offers the possibility of evaluating the cables themselves, as well as the connection quality between individual cable distributors based on their signal‐to‐noise ratio (SNR). The roll‐out of a large‐scale PLC infrastructure therefore not only ensures communication, but also introduces a tool for monitoring the entire network. To evaluate the potential of this data, we installed 38 PLC modems in three different areas of a German city with a population of about 150,000 as part of the Fühler‐im‐Netz (FiN) project. Over a period of 22 months, an SNR spectrum of each connection between adjacent PLC modems was generated every quarter of an hour. The availability of this real‐world PLC data opens up new possibilities to react to the increasingly complex challenges in future smart grids. This paper provides a detailed analysis of the data generation and describes how the data was collected during normal operation of the electricity grid. In addition, we present common anomalies, effects, and trends that could be observed in the PLC data at daily, weekly, or seasonal levels. Finally, we discuss potential use cases and the remote inspection of a cable section is highlighted as an example.