bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable water resource planning at the basin scale with simultaneous goals of agricultural development and wetland conservation
Authors: Hatamkhani Amir , KhazaiePoul Ahmad , Moridi Ali 
Published: May 2022

Abstract
Reducing the quantity of water in recent years has increased the competition between development projects and the environment. Wetlands are increasingly under pressure due to human activities. The most serious threats to wetlands are excessive agriculture and the diversion of water for irrigation. In recent years, due to water shortage and drought, wetland dryness in Iran has caused many problems, including the dust crisis. Therefore, planning at the basin scale is necessary to achieve sustainable development, which emphasizes the employment of mathematical models. In this study, using a reliability-based simulation–optimization approach, development planning in the Karkheh basin with the following two objectives is investigated: (1) total area under cultivation of agricultural development sectors and (2) supply reliability of the environmental flow requirement. The Water Evaluation and Planning (WEAP) model is used for the simulation of water resources and the multi-objective particle swarm optimization (MOPSO) algorithm is employed for optimization. The results show that in addition to significantly improving the supply reliability of the wetland requirement (from 55 to 79%), the design of agricultural development projects has been optimized. The reliability-based model has prevented unsustainable developments in the basin. Also, the average supply reliability of agricultural demands has increased from 51% (in previous studies) to 72%.
Mixing of Fe3O4 nanoparticles under electromagnetic and shear conditions for wastewater treatment applications
Authors: Liosis C. , Karvelas E. , Karakasidis T. , Sarris I. 
Published: May 2022

Abstract
The ability of heavy metals to accumulate in living organisms, combined with the fact that they are not biodegradable, necessitates an expansion and improvement of the existing water purification methods. An effective mixing of contaminated water with heavy metals and magnetic nanoparticles is crucial for water treatment applications. In the present work, electromagnetic and shear mixing are combined to explore optimization mixing strategies. Mixing is studied through simulations under various initial conditions for two streams that are loaded with nanoparticles and one contaminated water stream that lies between the nanoparticle streams. In the present work, magnetic mixing is superimposed with a time-modulated gradient external magnetic field. The results show that as the radius ratio between the nanoparticles and the heavy metals increases, the external magnetic field is more effective insofar as the mixing of the nanoparticles is concerned. Moreover, for simulations where the radius ratio is higher than or equal to 10, an effective mixing is achieved. By comparing the velocity ratios, a better mixing is achieved in the case of higher velocity ratios. Also, minor effects on mixing are observed by comparing the ratios Vp/Vc = 10 and Vp/Vc = 20.
Irrigation water demand management with emphasis on pricing policy
Authors: Mohseni Simin , Zare Mehrjerdi Mohammad Reza , Abdolahi Ezzatabadi Mohammad , Mehrabi Boshrabadi Hossein 
Published: May 2022

Abstract
Serious constraints in increasing water supply have led countries around the world to seek solutions for managing water demand. Proper pricing of water is one of the foremost water demand management policies which can lead to the optimal water use. On the flip side, the quality of agricultural water is declining due to the uncontrolled abstraction of groundwater. In this regard, the present study aims to determine the economic value of different qualities of water throughout pistachio-growing regions of the Rafsanjan-Anar plain in Iran. Results reveal that the economic value and price elasticity of water demand differ among different groups. Freshwater, moderately saline water and highly saline water have the highest to lowest elasticity and shadow price, respectively. Additionally, comparison of the gross margin, which represents the profit from each activity, in two conditions including the unsustainable status quo and sustainable conditions intended by the Ministry of Energy, shows that although water use has declined by 50%, the gross margin has decreased by only 36%. This implies it is feasible to reduce water use in pistachio orchards by water re-allocation with a minimum decline in profit, which will both reduce water use and ensure high economic benefits for farmers.
Jan Polák, Toccamenti proibiti. Aspetti antropologici ed etici della masturbazione, Edizioni Sant’Antonio, Beau Bassin 2018, ss. 131.
Authors: Kućko Wojciech 
Published: May 2022

Rewolucja seksualna objawiła i znacząco rozszerzyła różne problemy związane z przekazywaniem życia, a także z ludzką seksualnością. Dla wielu, nie tylko wierzących, trudne są do przyjęcia dotychczasowe, sprawdzone argumenty ukierunkowane na poszanowanie sfery seksualnej i promowanie jej właściwego rozwoju. Tym bardziej aktualne i pożądane wydaje się poszukiwanie nowych form opisu i oceny moralnej zjawisk i zachowań dotyczących ludzkiej seksualności. Bardzo trudnym tematem w tej dziedzinie jest zagadnienie oceny etycznej masturbacji, przez jednych traktowane jako zwykły sposób zaspokojenia popędu seksualnego, przez innych zaś rzeczywistość demonizowana i naznaczona różnymi wypaczeniami. Ogromny wpływ na ocenę moralną mają w tej dziedzinie współczesne środki społecznego przekazu, a zwłaszcza Internet.
W tym kontekście bardzo ważna wydaje się praca czeskiego kapłana, ks. Jana Poláka, będąca owocem jego badań naukowych podczas studiów w Accademia Alfonsiana – Wyższym Instytucie Teologii Moralnej w Papieskim Uniwersytecie Laterańskim w Rzymie, która powstała z pomocą wybitnego włoskiego bioetyka i teologa moralisty o. prof. Maurizio Faggioniego OFM.
Opublikowana we włoskim wydawnictwie Edizioni Sant’Antonio, licząca 131 stron książka w języku włoskim, zawiera cztery rozdziały, w których w sposób logiczny i konsekwentny zaprezentowano badaną materię.
Evolving Era of “Sponges”: Nanosponges as a Versatile Nanocarrier for the Effective Skin Delivery of Drugs
Authors: Mullick Prashansha , R. Hegde Aswathi , Gopalan Divya , Pandey Abhijeet , Nandakumar Krishnadas , Jain Sanyog , Kuppusamy Gowthamarajan , Mutalik Srinivas 
Published: May 2022

Background:Nanosponge, as a carrier for the skin delivery system for drugs, plays a vital role. It not only serves to administer the drug to the targeted layer of skin but also increases the drug retention and deposition on the skin.Objective:In this review, we aim to highlight the effects of several processes and formulation variables prompting the characteristics of various nanosponges for the delivery of drugs into/ across the skin.Method:In the present review article, the overall introduction of nanosponges, their preparation, characteristic features, advantages, disadvantages, and factors affecting their preparation, are covered. Furthermore, an elaborative description of nanosponges for skin delivery and its toxicological perspective with some referential examples of nanosponge drugs has also been deliberated here.Results:Factors associated with the formation of nanosponges can directly or indirectly affect its efficacy in the skin delivery of drugs. These nanoforms are efficient in delivering the drugs which possess lower aqueous solubility, therefore, the aqueous solubility of drugs possessing a narrow therapeutic window can easily be enhanced. It also helps in achieving targeted drug delivery, controlled release of drugs, increases bioavailability, reduces drug toxicity, decreases drug degradation, and many more.Conclusion:Nanosponges have been identified as potential drug delivery carriers into as well as across skin. Delivery of biologics such as vaccines, enzymes, peptides, proteins, and antibodies, is also gaining attention in the recent past.
The Anti-atherosclerotic Effects of Natural Polysaccharides: From Phenomena to
the Main Mechanisms of Action
Authors: P. Karagodin Vasily , I. Summerhill Volha , Yet Shaw-Fang , Orekhov Alexander N. 
Published: May 2022

Abstract:
Polysaccharides (PSs) of plant origin have a variety of biological activities, including antiatherosclerotic,
but their use in atherosclerosis therapy is hindered by insufficient knowledge based on the cellular
and molecular mechanisms of action. In this review, the influence of several natural PSs on the function of
macrophages, viral activity and macrophage cholesterol metabolism has been discussed, considering the tight
interplay between these aspects in the pathogenesis of atherosclerosis. The anti-atherosclerotic activities of natural
PSs related to other mechanisms have also been explored. Directions for further research of the antiatherosclerotic
effects of natural PSs have been outlined, the most promising of which can be nutrigenomic
studies.
A Review on the Catalytic Applications of Polyaniline Supported Palladium (Pd@PANI) in C–C Coupling Reactions
Authors: Naidu Bandameeda Ramesh , Maddeboina Krishnaiah 
Published: May 2022

Abstract:The C ̶ C bond formation via the cross-coupling and homocoupling reactions of organic partners are central to the synthesis of many chemical probes and have valuable applications in the medicinal and pharmaceutical industries. Polyaniline (PANI) is the most useful performing polymer due to its non-toxicity, high stability, easy synthetic accessibility, and simplicity of doping/dedoping by treatment with aqueous acid and base. PANI plays a pivotal role as a polymer base for palladium (Pd) species and in most cases, the catalysts showed high yield, reaction transformation, and reusability. In this review, we discuss the application of the Pd@PANI catalyst for cross-coupling/homocoupling reactions, analysis, characterization, and reusability. We covered all literature about Pd@PANI catalyst functions in Suzuki-Miyaura, Heck, Sonogashira, and Ullmann coupling reactions.
Mathematical Oncology to Cancer Systems Medicine: Translation from
Academic Pursuit to Individualized Therapy with MORA
Authors: Majumder Durjoy 
Published: May 2022

Aim & Objective:
This article is aimed to understand the gradual development of cancer systems medicine and how this provides a better therapeutic strategy (in terms of drug selection, dose and duration) and patients care. Hence, this study is focused to understand the need and the evolving nature of the analytical models for the assessment of the outcome of different cancer therapeutics.

Background:
Presently, cancer is viewed from a quantitative standpoint; hence, several analytical models on different cancers have developed. From the information of cancer development to therapeutic advantage, mathematical oncology has contributed significantly. With a fewer number of variables, models in this area have successfully synchronized the model output with real-life dynamical data. However, with the availability of large scale data for different cancers, systems biology has gained importance. It provides biomedical insights among a large number of variables. And to get information for clinically relevant variables especially, the controlling variable(s), cancer systems medicine is suggested.

Methods:
In this article, we have reviewed the gradual development of the field from mathematical oncology to cancer systems biology to cancer systems medicine. An intensive search with PubMed, IEEE Xplorer and Google for cancer model, analytical model and cancer systems biology was made and the latest developments have been noted.

Results:
Gradual development of cancer systems biology entails the importance of the development of models towards a unified model of cancer treatment. For this, the model should be flexible so that different types of cancer and/or its therapy can be included within the same model. With the existing knowledge, relevant variables are included in the same model, followed by simulation studies that will enrich the knowledge base further. Such a deductive approach in the modelling and simulations efforts can help to tackle the adversity of individual cancer cases in future. This approach is indeed important to encompass the fourth industrial revolution in health sector.

Conclusion:
Towards the development of a unified modelling effort, a multi-scale modelling approach could be suitable; so that different researchers across the globe can add their contribution to enrich the same model. Moreover, with this, the identification of controlling variables may be possible. Towards this goal, middle-out rationalist approach (MORA) is working on analytical models for cancer treatment.
Nutraceutical Potential and Processing Aspects of Moringa oleifera as a
Superfood
Authors: Kaur Simranjeet , Chauhan Pratik N. , Harwansh Ranjit K. , Chakma Marjita , Kaur Simran 
Published: May 2022

Abstract:
Plants are used by almost 80% of the world's population for health and healing, and medicinal and aromatic plants account for 25% of all integrated pharmaceuticals. Moringa oleifera is a multi-purpose herbal plant that is utilized as a portion of human food and a therapeutic alternative all over the world. According to studies, it has been discovered as a plant with a wide range of health benefits, including nutritional and medicinal characteristics. It can live on nutrient-depleted soils and is drought-resistant, and it flourishes in wet tropics and scorching dry regions. With a pH of 5.0–9.0 and a minimum annual rainfall need of 250 mm and a maximum annual rainfall demand of over 3000 mm, it can endure a wide variety of rainfall. Moringa is a plant that can aid in the fight against climate change. Moringa’s ability to respond to water stress and its tolerance to it were investigated in this study. Moringa is used in traditional medicine all over the world for a variety of ailments, including skin infections, anemia, anxiety, asthma, blood impurities, bronchitis, chest congestion, cholera, infections, fever, glandular, swelling, headaches, abnormal blood pressure, hysteria, pain in joints, pimples, psoriasis, respiratory disorders, scurvy, semen deficiency, sore throat, sprain, tuberculosis, for intestinal worms, lactation, diabetes, and pregnancy. Moringa oil is prized in the cosmetic business because of its unique properties. Moringa oil is light and easily absorbed by the skin. It's ideal for massage and aromatherapy purposes. Although M. oleifera's nutritional value is lower than that claimed by popular nutritional claims, its abundance in food-insecure areas and wide range of nutrients keep it viable as a nutritious food source for populations in low- and middle-income countries. Malnutrition, which includes undernutrition, micronutrient deficiency, and overnutrition, is more widespread than hunger per se and affects most nations around the world. The diversity and quality of food produced and consumed are crucial in reducing the triple burden of malnutrition. In this climate, fruit, vegetables, and nuts are quickly becoming the focus of the nutrition community. Moringa's diet is higher in polyunsaturated fatty acids (PUFAs) than in saturated fatty acids (SFAs).
The Effect of Substituents and Functional Groups on Enhancing the Antioxidant Activity of Benzoin Derivatives
Authors: Balasundaram Thanuja , Kripa Kavasseri Ganesan , Bhavadharani Thiyagarajan , Kanagam Charles 
Published: May 2022

Background:2-phenyl hydrazine-1-hydroxy, 1-[2-chlorophenyl] -2-4’-methoxyphenyl] ethane and 2-oxime-1-hydroxy, 1-[2-chlorophenyl] -2-4’-methoxyphenyl] ethane derivatives of benzoin have been synthesized from 2’chloro-4-methoxy benzoin by addition reaction. Structural elucidation of the synthesized compounds was carried out through FT-IR, FT-NMR studies. The presence of electron-withdrawing and electron-donating groups enhanced the antioxidant activity, which was analyzed by 2,2-diphenyl-1-picrylhydrazyl assay, 2,2'-azino-bis (3-ethylbenzothiazoline-6- sulfonic acid) scavenging assay, hydrogen peroxide radical scavenging assay, and Ferric reducing antioxidant power assay methods. The effect of functional groups and substituents in the core structure was studied and compared with its parent compound.Aim and Objective:In this manuscript, two derivatives of benzoin viz. 2-phenyl hydrazine-1-hydroxy, 1-[2-chlorophenyl] -2-[4’-methoxyphenyl] ethane and 2-oxime-1-hydroxy, 1-[2-chlorophenyl]-2-[4’- methoxyphenyl] ethane (HA) derivatives were synthesized by benzoin condensation and followed by addition reaction to find a potential anti-oxidant agent.Materials and Methods:Qualitative analyses were determined by FT-IR and FT-NMR studies. Antioxidant activities were tested by DPPH assay, ABTS assay, and FRAP assay H2O2 methods.Results:From the obtained results, it is confirmed that the effect of withdrawing and electron releasing groups as a substituent in the core structure of parent compounds enhances the activity of antioxidant. The role of substituents is discussed in detail.Conclusion:The results of the biochemical assay reveal that the synthesized compounds serve as good free radical inhibitors and scavengers, which inhibit the oxidative reactions, and are responsible for cell damage, food spoilage, etc. The promising anti-oxidant activities are because of the effective substituents which play a prominent role in the drug industries.
Efficacy of Anti-VEGF Drugs Based Combination Therapies in Recurrent
Glioblastoma: Systematic Review and Meta-Analysis
Authors: Solipuram Vinod , Soltani Ramin , Venkatesulu BP , Annam Saketh , Alavian Firoozeh , Ghasemi Sorayya 
Published: May 2022

Background:
Recurrent glioblastoma multiforme (rGBM) has a grim prognosis, with current
therapies offering no survival benefit. Several combination therapies involving anti-VEGF agents
have been studied with mixed results.

Methods:
A systematic search was performed using five electronic databases: PubMed, Scopus, ISI,
Embase, and the Cochrane Library, without language limitations. The primary outcome of interest was
progression-free survival (PFS). Secondary outcomes were overall survival (OS), objective response
ratio (ORR), and grade ≥ 3 adverse events. Estimates for PFS and OS were calculated as random effects
hazard ratio (HR) with 95% confidence intervals (CIs) using the generic inverse variance method.
Estimates for ORR and grade ≥ 3 adverse events were calculated using a random-effects risk ratio
(RR) with 95% confidence intervals (CIs) using the Mantel-Haenszel method.

Results:
Thirteen studies met the inclusion criteria and a total of 1994 patients were included in the
analysis. There was no statistically significant improvement in PFS (HR 0.84; 95% CI (0.68, 1.03);
I2=81%), OS (HR 0.99; 95% CI (0.88, 1.12); I2=0%), and ORR (RR 1.36; 95% CI (0.96, 1.92);
I2=61%) in the combination therapy group when compared to the control group. Significantly higher
grade ≥ 3 adverse events (RR 1.30; 95% CI (1.14, 1.48); I2=47%) were seen in the combination therapy
when compared to the control group.

Conclusion:
Our analysis showed that the use of combination therapy with anti-VEGF agents did not
offer any benefit in PFS, OS, or ORR. In contrast, it had significantly higher grade 3-5 adverse events.
Further studies are needed to identify effective therapies in rGBM that can improve survival.
Implementation of Virtual Reality in Health Professional Higher Education: Protocol for a Scoping Review
Authors: Lie Silje Stangeland , Helle Nikolina , Sletteland Nina Vahl , Vikman Miriam Dubland , Bonsaksen Tore 
Published: May 2022

Background
The use of virtual reality in higher education show great potential to promote novel and innovative learning experiences. Until recently, virtual reality has mostly been used in technical higher education, but lately medical education programs have begun using virtual reality. Virtual reality for health professional education improves the knowledge and skills of health professionals compared with traditional or other digital education initiatives. However, the implementation of technology in higher education is slow because of barriers to technology use and innovative and successful practices are not shared. It is, therefore, of great interest to explore how virtual reality is implemented in higher health professional and continuing education.

Objective
The aim of this scoping review is to identify studies that reported implementation of virtual reality in higher health professional education, to identify barriers and facilitators for implementation, and to highlight research gaps in this area.

Methods
The scoping review will be conducted according to JBI Evidence Synthesis methodologies. CINAHL, the Academic Search Elite and Education Source electronic databases, and Google Scholar will be searched for studies published between 2017 and 2022. In addition, manual searching of key items, reference tracking, and citation tracking will be performed. Searches for white papers will also be manually conducted. All authors will independently extract data from full-text papers. We will use qualitative content analysis to abstract the findings.

Results
The literature searches were conducted in January and February 2022. The review is expected to be completed by fall 2022, after which time it will be submitted for publication.

Conclusions
We anticipate that, from the review, we will be able to coordinate recommendations for and present the challenges of virtual reality initiatives in health professional education programs. We will present recommendations for future research.

International Registered Report Identifier (IRRID)
DERR1-10.2196/37222
Deconstructing TikTok Videos on Mental Health: Cross-sectional, Descriptive Content Analysis
Authors: Basch Corey H , Donelle Lorie , Fera Joseph , Jaime Christie 
Published: May 2022

Background
Social media platforms that are based on the creation of visual media, such as TikTok, are increasingly popular with adolescents. Online social media networks provide valuable opportunities to connect with each other to share experiences and strategies for health and wellness.

Objective
The aim of this study was to describe the content of the hashtag #mentalhealth on TikTok.

Methods
This cross-sectional, descriptive content analysis study included 100 videos with the hashtag #mentalhealth on TikTok. All videos that included the hashtag #mentalhealth were analyzed and coded for the presence of content categories. Additionally, the comments to each video were viewed and coded for content in the following themes: offering support or validation; mentioning experience with suicide or suicidal ideation; mentioning experience with self-harm; describing an experience with hospitalization for mental health issues; describing other mental health issues; and sharing coping strategies, experiences of healing, or ways to feel better.

Results
Collectively, the 100 videos studied received 1,354,100,000 views; 266,900,000 likes; and 2,515,954 comments. On average, each video received 13,406,930.69 (SD 8,728,095.52) views; 2,657,425.74 (SD 1,449,920.45) likes; and 24,910.44 (SD 21,035.06) comments. The only content category observed in most (51/100, 51%) of the videos included in the sample was “general mental health.” The remaining content categories appeared in less than 50% of the sample. In total, 32% (32/100) of the videos sampled received more than the overall average number of likes (ie, more that 2.67 million likes). Among these 32 videos, 23 (72%) included comments offering support or validation and 20 (62%) included comments that described other mental health issues or struggles.

Conclusions
With over 1 billion cumulative views, almost half of the assessed TikTok videos included in this study reported or expressed symptoms of mental distress. Future research should focus on the potential role of intervention by health care professionals on social media.