bluuebunny/crossref_metadata_2025_split huggingface dataset:
Textural Properties and Adsorption Behavior of Zn-Mg-Al Layered Double Hydroxide Upon Crystal Violet Dye Removal as a Low Cost, Effective, and Recyclable Adsorbent
Authors: Abdel-Hady E. E. , Mohamed Hamdy F. M. , Hafez Sarah H. M. , Fahmy Abdalla M. M. , Magdy Abdelhamed , Mohamed Aya S. , Ali Eman O. , El-Hamed Hager R. Abd , Mahmoud Osama M. 
Published: December 2022

Abstract
The preparation of adsorbents plays a vital part in the adsorption method. In particular, many adsorbents with high specific surface areas and unique shapes are essential for the adsorption strategy. In this study, a Zn-Mg-Al/layer double hydroxide (LDH) had been designed via a facile co-precipitation process. Adsorbent based on Zn-Mg-Al/LDH was utilized to remove crystal violet (CV) from the wastewater. The impacts of the initial dye concentration, pH, and temperature on CV adsorption performance were systematically examined. The adsorbents were analyzed both before and after adsorption using FTIR, XRD, and SEM. The roughness parameters and surface morphologies of the produced LDH were estimated using 3D SEM images. Under the best conditions (dose of adsorbent = 0.07 g and pH = 9), the maximum adsorption capacity has been achieved. Adsorption kinetics studies revealed that the reaction that led to the adsorption of CV dye onto Zn-Mg-Al/LDH was a pseudo-second-order model. Additionally, intraparticle diffusion suggests that Zn-Mg-Al/LDH has fast diffusion constant for CV molecules (0.251 mg/(g.min1/2)). Furthermore, as predicted by the Langmuir model, the maximal Zn-Mg-Al/LDH adsorption capacity of CV was 64.80 mg/g. The CV adsorption equilibrium parameter (RL) onto Zn-Mg-Al/LDH was 0.769, indicating that adsorption was favorable. The effect of temperature was performed at 25, 35, and 45 oC in order to establish the thermodynamic parameters ∆Ho, ∆So, and ∆Go. The computed values indicated exothermic and spontaneous adsorption processes. The study presented here might be used to develop new adsorbents with enhanced adsorption capabilities for the purpose of protecting the environment of water. ‎
Climate, landscape, and life history jointly predict multidecadal community mosquito phenology
Authors: Campbell Lindsay P. , Sallam Mohamed F. , Bauer Amely M. , Tavares Yasmin , Guralnick Robert P. 
Published: December 2022

Abstract
Phenology of adult host-seeking female mosquitoes is a critical component for understanding potential for pathogen maintenance and amplification in the natural environment. Despite this importance, long-term multi-species investigations of mosquito phenologies across environments and differing species’ life history traits are rare. Here we leverage long-term mosquito control district monitoring data to characterize annual phenologies of host-seeking female mosquito species over a 20-year time period in suburban Illinois, USA. We also assembled data on landscape context, categorized into low and medium development, climate variables including precipitation, temperature and humidity, and key life history traits, i.e. overwintering stage and early versus late-season fliers. We then fit linear mixed models separately for adult onset, peak abundances, and flight termination with landscape, climate and trait variables as predictors with species as a random effect. Model results supported some expectations, including warmer spring temperatures leading to earlier onset, warmer temperatures and lower humidity leading to earlier peak abundances, and warmer and wetter fall conditions leading to later termination. However, we also found sometimes complex interactions and responses contrary to our predictions. For example, temperature had generally weak support on its own, impacting onset and peak abundance timing; rather temperature has interacting effects with humidity or precipitation. We also found higher spring precipitation, especially in low development contexts, generally delayed adult onset, counter to expectations. These results emphasize the need to consider how traits, landscape and climatic factors all interact to determine mosquito phenology, when planning management strategies for vector control and public health protection.
Flood Susceptibility Mapping in the Baitarani River basin, implementing cloud-based IS-AHP Technique
Authors: Sethi Ranu Rani , Dandapat Asit Kumar , Jena S. K. , SANKALP SOVAN , Panda D. K. , Patra P. K. 
Published: December 2022

Abstract
River basin planning includes hydrological, and ecological analysis, in which decisions are made over different uses and demands of water resources and associated parameters involved the in sustainable use of natural resources. Baitarani being one of the 6th largest river basins in Odisha faces all water related challenges in both upper and lower catchments. As one of the most frequent environmental disasters, floods are consistently cited in hotspots in the eastern region of India. So, utilizing the Google Earth Engine (GEE) technology and the analytical hierarchy process (AHP) in GIS platform with a cloud computing API, flood vulnerability maps were generated. Topographic ruggedness Index (TRI), Topographic Wetness Index (TWI), and Stream Power Index (SPI), elevation, lithology, soil, slope gradient, drainage density, length from the drainage system, Land Use and Land Cover (LULC), Normalized Difference Vegetation Index (NDVI) are a few of the nearly eleven flood factors that were prepared and included in the flood modeling. Analytical hierarchy process approach weights were used to assess the effects of each component influencing flood risk. According to the data, elevation is the main cause of floods, with flooding affecting 15% of the total area. The flood danger index is also analyzed. Additionally, within the Baitarani River basin, between 1995 and 2020, there will be an 8% decline in agriculture land and a 13.93% increase in fallow land. The outcomes of this research can help managers, researchers, and planners manage natural resources, find locations that could be vulnerable to flooding, and lessen damage.
Biological potential of silver nanoparticles synthesized by an endophytic fungus Metapochonia suchlasporia-KUMBMDBT-23
Authors: D Manjunatha , S Akarsh , G Nandish , H.V Sowmya , G.T Megha , S Nagaraju , B Thippeswamy 
Published: December 2022

Abstract

In this study, we demonstrated a simple, green, and eco-friendly method for the synthesis of silver nanoparticles using the endophytic fungus Metapochonia suchlasporia-KUMBMDBT-23 isolated from the medicinal plant Argemone mexicana. Silver nanoparticles were synthesised using the biomass cell filtrate of Metapochonia suchlasporia, which was identified by morphological and molecular characterization. The fungus extract was extracted with ethyl acetate (1:1 V/V) and was analysed by GC-MS. Biosynthesized silver nanoparticles were investigated by Bio-spectrophotometer, Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy – Energy Dispersive Analysis of X-ray, (SEM-EDAX), X-ray diffraction (XRD) and Particle size analysis by dynamic light scattering (DLS). Metapochonia suchlasporia synthesised silver nanoparticles were effective against gram-positive and gram-negative human pathogenic bacteria. Using market antibiotics, the antimicrobial enhancing activity and minimum inhibitory concentration of silver nanoparticles was evaluated. The antifungal activity of silver nanoparticles against fungal infections was determined. Moreover, silver nanoparticles synthesised showed effect of DPPH and ABTS scavenging activities. Further in -vitro anticancer activity was determined by MTT assay using HePG2 and A498 cell lines. In -vitro anti-inflammatory activity was determined by egg albumin, bovine serum albumin denaturation test and membrane stabilization test, HRBC, in- vivo anti-inflammatory activity was determined by inducing Female Swiss Albino mice with inflammatory agent’s carrageenan paw edema. This study showed silver nanoparticles generated by microbes are effective inhibitors and have potential biological implications.
Effect of waste concrete powder on concrete properties and microscopic mechanism analysis
Authors: Li Te , Tier Laire 
Published: December 2022

Abstract
With the rapid development of urban urbanization, a large number of old buildings that do not meet the urban construction planning have been demolished, and a large number of buildings left a lot of construction waste. The direct waste of construction waste is not only a large waste of sand and cement resources, but also increases the production cost of construction enterprises. The slump and rheology tests show that the addition of waste concrete powder is unfavorable to the working performance of concrete. The rheology shows that the waste concrete powder leads to the increase of friction force and the decrease of slump. With the increase of substitution rate, the compressive strength decreases. ICP shows that the dissolution of early concrete powder is involved in hydration. Nanoindentation shows that the hydration products change. In addition, because the waste concrete powder is rich in Si, the hydration product Si / Ca increases. In addition, MIP and UPV results show that the durability of concrete with concrete powder becomes worse. Since the concrete powder also needs to be calcined and ground, although there is still more CO2 emissions, there is still a slight decrease compared with cement. Therefore, with the increase of the substitution rate, certain economic and environmental benefits can be obtained.
A breakdown of metabolic reprogramming in microglia caused by CKLF1 exacerbates immune tolerance in the ischemic stroke
Authors: Ma Wenyu , Wu Qinglin , Wang Shasha , Wang Hongyun , Ye Junrui , Sun Hongsuo , Feng Zhongping , He Wenbin , Chu Shifeng , Zhang Zhao , Chen Naihong 
Published: December 2022

Abstract

Ischemic stroke has a prominent pathogenic hallmark called reactive microglia, which is a predictor of prognosis. The precise involvement of microglia in stroke etiology, however, is still unknown. We found that chemokine like factor 1 (CKLF1) causes acute microglial inflammation and metabolic reprogramming from oxidative phosphorylation to glycolysis utilizing metabolic profiling, which was reliant on the AMPK-mTOR-HIF-1α signaling pathway. Microglia, once activated, entered a chronic tolerant state as a result of widespread energy metabolism abnormalities and therefore reduced immunological responses, including cytokine release and phagocytosis. It was also found metabolically dysfunctional microglia in the mice using genome-wide RNA sequencing by chronic administration of CKLF1 directly, as well as the decrease of inflammation response. Finally, we showed that loss of CKLF1 reversed the defective immune response of microglia, as manifested by kept its phagocytosis to neutrophils, thereby mitigating long term outcomes of ischemic stroke. Overall, CKLF1 plays a crucial part in the relationship between microglial metabolic status and immune function in stroke, which prepares a potential therapeutic strategy for ischemic stroke.
Anisotropy in Multiferroic CuCrP2S6
Authors: Wang Xiaolei , Shang Zixuan , Zhang Chen , Kang Jiaqian , Liu Tao , Wang Xueyun , Chen Siliang , Liu Haoliang , Tang Wei , Zeng Yu-Jia , Guo Jianfeng , Cheng Zhihai , Liu Lei , Pan Dong , Tong Shucheng , Wu Bo , Xie Yiyang , Wang Guangcheng , Deng Jinxiang , Zhai Tianrui , Deng Hui-Xiong , Hong Jiawang , Zhao Jianhua 
Published: December 2022

AbstractMultiferroic materials have great potential in non-volatile devices for low-power and ultra-high density information storage, owing to their unique characteristic of coexisting ferroelectric and ferromagnetic orders. The effective manipulation of their intrinsic anisotropy makes it promising to control the multiple degrees of freedom of the storage "medium". Here, we have discovered intriguing electrical and magnetic anisotropies within the intralayer of CuCrP2S6, a promising van der Waals multiferroic material. The in-plane uniaxial anisotropies of the current rectifications, magnetic properties and magnon modes are demonstrated and manipulated by electric direction/polarity, temperature variation and magnetic field. More important, we have observed spin-flop transition corresponding to specific magnon modes, and it is well supported by theoretical calculations. Our work provides the first observation of electrical and magnetic anisotropies with same easy axis in van der Waals multiferroics, which will stimulate novel device applications of artificial bionic synapses, multi-terminal spintronic chips and magnetoelectric devices.
Platelet Indices and Blood Pressure: A Multivariable Mendelian Randomization Study
Authors: Xu Yuhan , Guo Yijing 
Published: December 2022

Abstract
Background: Platelet indices are blood-based parameters reflecting the activation of platelets. Previous studies have identified an association between platelet indices and blood pressure (BP). However, the causal inferences are prone to be biased by confounding effects and reverse causation. We performed a Mendelian randomization (MR) study to compare the causal roles between genetically determined platelet indices and BP level.
Methods: Single-nucleotide polymorphisms (SNPs) associated with platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), and BP at the level of genomewide significance (p < 5 × 10−8 ) in the UK Biobank were used as instrumental variables. In bi-directional univariable MR analyses, Inverse variance-weighted (IVW), MR-Egger, and weighted median methods were used to obtain estimates for the individual causal power. In addition, heterogeneity and sensitivity analysis was performed to examine the pleiotropy of effect estimates. Finally, multivariable MR analyses were undertaken to disentangle the comparative effects of four platelet indices on blood pressure.
Results: In the univariable MR analyses, Increased levels of PLT and PCT were associated with higher BP, and PDW was associated with higher DBP alone. In the reverse direction, SBP had a minor influence on PLT and PCT. In multivariable MR analysis, PDW and PLT revealed an independent effect, whereas the association for PCT and MPV was insignificant after co-linear correction.
Conclusion: These findings suggest that platelet and BP may affect each other. PDW and PLT are independent platelet indices influencing BP. Increased platelet activation and aggregation may be involved in the pathogenesis of hypertension which may provide insights into evaluating thromboembolic events in people with high BP. The necessity of initiating antiplatelet therapy among hypertension groups need further investigation.
Transcriptome Analysis Reveals Association of Carotenoid Metabolism Pathway with Fruit Color in Melon
Authors: Diao Qiannan , Tian Shoubo , Cao Yanyan , Yao Dongwei , Fan Hongwei , Zhang Yongping 
Published: December 2022

Abstract
Flesh color is an important quality of melon (Cucumis melo L.) and is determined mainly by carotenoid content, awarding them with colors, aromas, and nutrients. enhancing the nutritional and health benefits of fruits and vegetables for humans. In this study, we performed transcriptomic analysis of two melon inbred line “B-14” (orange-flesh) and “B-6” (white-flesh) at three developmental stages. We observed that the β-carotene content of inbred line “B-6” (14.232 μg/g) was significantly lower than that of inbred line “B-14” (0.534 μg/g). RNA-sequencing and quantitative reverse transcription PCR analyses were performed to identify differentially expressed genes (DEGs) between the two inbred lines at different stages; the DEGs were analyzed using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes databases (KEGG). We identified 33 structural DEGs in different developmental periods of the two lines that were related to carotenoid metabolism. Among them, PSY, Z-ISO, ZDS, CRTISO, CCD4, VDE1, and NCED2 were highly correlated with carotenoid content. Thus, this study provides a basis for molecular mechanism of carotenoid biosynthesis and flesh color in melon fruit.
ANGPTL8 as an Inflammatory Trigger Aggravated Microglial Pyroptosis in the Pathogenesis of Alzheimer’s Disease
Authors: Wei Jiarui , Hu Lin , Xu Shufan , Li Yifan , Liao Fusheng , Zhang Xiaoqiao , Fang Xingang , Ding Li , Wang Ting , Chen Zhuo , Su Shanchun , Zhang Qiufang , Guo Xingrong 
Published: December 2022

Abstract
Background: Increasing evidence indicates that Alzheimer’s disease (AD) is not only a disease of the brain but also an autoimmune disorder of innate immunity. Pyroptosis-mediated inflammation activates microglia, which are innate immune regulators that play an important role in AD formation. New studies have found that some peripheral proinflammatory cytokines can penetrate the blood–brain barrier (BBB), thereby activating microglial pyroptosis and promoting inflammation in the brain. However, the impact of the liver-brain axis on the development of AD remains elusive. Here, we show that liver-secreted ANGPTL8 acts as an inflammatory trigger and penetrates the BBB, contributing to the progression of AD.
Methods: ANGPTL8-/- mice were crossed with 5×FAD mice to obtain WT, 5×FAD, ANGPTL8-/-, and ANGPTL8-/- 5×FAD mice. We checked whether ANGPTL8 knockout affected learning and memory impairment using the Morris water maze (MWM) task. Tiofavin-S (Tio-S) and Nissl staining were used to analyze amyloid β (Aβ) deposition and the number of neurons in the four groups of mice. The effects of ANGPTL8 on the activation of microglia and neuroinflammation were analyzed in vitro and in vivo by immunofluorescence and flow cytometry. Extracting single-cell sequencing library data and in situ hybridization, etc., were used to analyze the source of ANGPTL8 that promotes AD progression. RNA interference assay, transmission electron microscopy, western blotting, etc., were used to study the mechanisms of ANGPTL8 in regulating AD progression. Finally, drug screening was used to identify an effective inhibitor of ANGPTL8.
Results: ANGPTL8 knockout improved cognitive functions and decreased Ab deposition in 5xFAD mice. ANGPTL8 levels were significantly increased in the livers of 5xFAD mice and upregulated by Aβ stimulation. Secreted Aβ in turn promotes the expression of ANGPTL8, and secreted ANGPTL8 acts as an inflammatory trigger and directly interacts with the microglia membrane receptor PIRB to activate downstream PIRB/NLRP3 signaling, thereby inhibiting the phagocytic capacity of microglia to reduce the clearance of Aβ by promoting pyroptosis. The antidiabetic drug metformin can inhibit the expression of ANGPTL8 and improve the learning and memory of 5xFAD mice.
Conclusions: Our study identified ANGPTL8 as a novel peripheral inflammatory trigger that regulates the liver-brain axis and aggravates microglial pyroptosis via the PIRB/NLRP3 pathway to accelerate the pathogenesis of AD. Our results also indicate that the serum ANGPTL8 level represents a potential diagnostic marker for diseases featuring AD and that targeting ANGPTL8 holds great promise for developing innovative therapies to treat AD.
Bioorthogonal Imaging Uncovers Sex- and Diet-dependent Lipid Metabolic Changes in Drosophila Brain during Aging
Authors: Li Yajuan , Chang Phyllis , Sankaran Shriya , Jang Hongje , Nie Yuhang , Zeng Audrey , Hussain Sahran , Wu Jane , Chen Xu , shi Lingyan 
Published: December 2022

Abstract
Lipid metabolism has been associated with brain aging and is regulated by diet, however, the underlying mechanisms are elusive. Using deuterium water (D2O) probed stimulated Raman scattering (SRS) imaging, we demonstrated brain lipid metabolism in Drosophila manipulated by diet in an age- and sex-dependent manner, and important roles of glial insulin/IGF-1 signaling (IIS) pathway in brain lipid metabolism. High sugar diets enhanced lipogenesis while dietary restriction promotes both lipogenesis and lipolysis, and these effects were impaired in both chico1/+ and dfoxo Drosophila loss-of-function mutants. Lipid synthesis and mobilization in brain lipid droplets were reduced with aging, but old chico1/+ flies maintained high lipid metabolic activities whereas aged dfoxo mutants showed increased lipogenesis in females but decreased lipogenesis in males. Diet-regulated brain lipid metabolism did not show sexual difference in both mutants as that in control. Our study supports the crucial role of glial IIS in regulating brain lipid metabolism.
Weibel Instability in Relativistic-Maxwellian Laser Fusion Plasma
Authors: Belghit Slimen , Zaidi Beddiaf 
Published: December 2022

Abstract
We study the Weibel instability (WI) in plasma heated by a laser pulse in the relativistic regime under Jüttner-Maxwell distribution function (relativistic Maxwellian), for this the basic equation in our model is the relativistic Vlasov equation .we solve the dispersion relation of low frequency and deduce the growth rate of WI. The main obtained result is that the choice of plasma density, quick scale time and electronic temperature can be stabilized the value of growth rate of WI; when shown clearly that the relativistic effect sureties the spectrum of growth rate of WI.
Strength and behavior of CFST columns using M-Sand replacing fine aggregate: Experimental, Theoretical and Numerical analysis
Authors: S.M. Shehnaz , S.M. Imam Shah , G Mohan Ganesh 
Published: December 2022

Abstract
As fine aggregate is becoming the most expensive material due to its scarcity, use of alternate is inevitable. Manufactured Sand (M-Sand) is one such admixture that can be replaced with fine aggregate. 32 Concrete Filled Steel Tubes (CFST) with circular cross section, subjected to axial load without eccentricity, divided in to 4 series and filled with 4 different mixes are presented in this paper. CFST specimens with outer diameter (D) of 76 mm, Diameter to thickness (D/t) of 45.84 and Length to Diameter (L/D) of 7, 8, 9 and 10 were considered. Concrete filled in the specimens had M30 grade with fine aggregate replaced with M-Sand at 0, 15, 20 and 25%. As the replacement of M-Sand increased, concrete compressive strength increased and eventually enhanced the axial carrying capacity of the columns. However, increase in L/D, decreased the column capacity. Impact of axial load on parameters like Strength Index (SI), Confinement (ξ), percentage contribution of steel and concrete are also presented. Further, axial load values of the specimens were compared with design values of Eurocode (EC4), American Code (ACI-318), Australian Code (AS5100) and Japanese Code AIJ codes. Experimental results were very near to EC4 and ACI − 318 design values while remaining codes gave unconservative results. Finally, Finite Element Analysis (FEA) model using ABAQUS software was developed for all the specimens to study the behavior of column capacity, failure mode and displacement curves.