bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of capillary water migration in the sandstone block based on electrical resistivity measurements
Authors: Yang Haiqing , Chen Chiwei , Zhao Gang , Zhou Jiayuan 
Published: July 2022

Abstract
Capillary water migration observed in sandstone block seriously affects pore structure and mechanical properties under the influence of the natural environment. In addition to continuous capillary action, the salt solution will be crystallized in the pores under the dry-wet cycles, and thereby deterioration occurs on the surface. To investigate the spatial and temporal evolution of material structure, a series of capillary water absorption tests were carried out on sandstone samples. Furthermore, stereo microscope and high-density resistivity instrument were conducted to monitor the characteristics of the surface and internal pores at intervals. Meanwhile, a novel Terzaghi model was proposed for modeling the variation trend of capillary water rise over time, in which the variation in porosity were characterized by saturated degree. The electrical resistivity measurements in millimeter-scale show that the rising trend of the dry-wet interface resembles the saddle shape. Moreover, the soluble salt is more enriched near the dry-wet interface under the capillary action due to the slow rise of the salt solution when it reaches the dry-wet interface. With the increase of dry-wet cycles, an obvious salt layer appeared on the surface accompanied by sandstone block crisp and pulverized phenomena, and significantly increased the capillary water absorption rate and porosity. In detail, the maximum mass loss due to mineral detachment of the surface reaches 2% in a single dry-wet cycle. Additionally, the study provides some references for evaluating the capillary action and deterioration mechanism of similar porous media materials by using a rapid and nondestructive method.
Preparation and characterization of imprinted bacterial cellulose aerogel for efficient recovery of Er(III) from end-of-life erbium-doped fibers
Authors: Zheng Xudong , Wang Shangxiong , Li Ang , Xu Tongtong , Mei Jinfeng , Li Zhongyu 
Published: July 2022

Abstract
Selective recovery of high value rare earth elements from end-of-life rare earth products is an economical and environmental measure. In this study, we used bio-based material (2,2,6,6-tetramethyl-1-piperidinyloxy-mediated bacterial cellulose) as the substrate material to construct a highly elastic imprinted bacterial cellulose aerogel (BCP-I) in synergy with chitosan (CS) and polyethyleneimine (PEI) for highly selective adsorption Er(III). CS and PEI contain abundant functional monomers, which can cooperate with bacterial cellulose and Er(III) to construct more imprinting sites, which not only improves the adsorption performance of BCP-I, but also makes the aerogel more stable. In order to analyze physical and chemical properties of aerogels, it was characterized by scanning electron microscope, fourier transform infrared spectrometer and thermogravimetric analysis. Adsorption experiments showed that BCP-I had a good adsorption effect on Er(III), and the maximum adsorption capacity could reach 95.99 mg g− 1. Cyclic experiments show that the adsorption property of BCP-I is still in good condition. All in all, BCP-I with environment-friendliness, high selectivity and good reproducibility is a good choice for recovery of Er(III).
Research paper Do subjectivities and subject-making influence community participation in climate change adaptation? the case of Vietnam
Authors: Le Van Thi Hong , Tran Thong Anh , Rola-Rubzen Fay 
Published: July 2022

Abstract
Social inclusion in climate change adaptation decision making and implementation has long been espoused by researchers and practitioners with primary focusing on factors affecting community participation. This raises the question on how different stakeholders, especially powerholders, subjectify and create an environment for community participation. In this paper, we utilised the intersection between community participation and the subjectivities lens to examine how dominant powers systematically operate to influence community engagement in adaptation and how and why local communities are included or excluded from adaptation as a result of subject-making, using Vietnam as a case study. Using semi-structured interviews with policymakers, practitioners, local authorities and focus group discussions with local communities, we examined how the key respondents stereotyped local roles and capacity in agricultural adaptation activities. The results showed that subtle but pervasive subjectivities and subject-making processes constrain community participation by affecting perceptions and, subsequently, actions of key stakeholders that undermine local roles and capacity in undertaking adaptation. This perpetuates the power imbalance between local communities and governments at different levels of administration. The findings contribute to the prevailing scholarship of climate change adaptation that, under an authoritarian regime, local capacity is undermined not only by powerholders but by community members as they consent to government decisions.
The relationship between tiem perspetive and life satisfaction: Career adaptability as an intermediate variable
Authors: Tien Hsiu-Lan Shelley , Li Tian Tian 
Published: July 2022

Abstract
The purpose of the study was to test the applicability of the “Time Perspective Scale” for the emerging adult population in China. We also examined the relationship between time perspective and life satisfaction by using career adaptability as an intermediary variable. The participants were 725 young adults aged from 18 to 27. The instruments included the “Time Perspective Scale”, “Life Satisfaction Scale” and “Career Adaptability Scale”. The mediating effect of career adaptability between time perspective and life satisfaction was investigated by the deviation correction percentile bootstrap method. The results indicated the following: (1) The analysis of the items showed that the correlation coefficient between 18 items of the time perspective scale and the total score of dimensions was above 0.4, which met the statistical requirements; (2) The Cronbach's probability coefficients of the four sub-dimensions of the time perspective scale were 0.86, 0.86, 0.91 and 0.75, respectively; (3) The commonality values of this scale were greater than 0.2, which met the statistical requirements; (4) The results of confirmatory factor analysis supported the four-factor structure of time perspective scale: future positive, future negative, adventure stimulus and fatalistic enjoyment; (5) Each dimension of time perspective was significantly correlated with the dimensions of career adaptability and life satisfaction; (6) Career control and career confidence were found to play a mediating role between time perspective and life satisfaction, while the mediating role of career concern and career curiosity was not significant. We concluded that the time perspective scale has good reliability and validity. Career control and career confidence mediate the relationship between time perspective and life satisfaction. Discussion and suggestions for future research were also provided.
Global warming profoundly changes the spatial distribution of nitrogen use and losses in croplands
Authors: Ren Chenchen , Zhang Xiuming , Reis Stefan , Jin Jiaxin , Xu Jianming , Gu Baojing 
Published: July 2022

Abstract
Maintaining food production while reducing agricultural nitrogen pollution is a grand challenge under the threats of global climate change, which has exerted negative impacts on agricultural sustainability. How global agricultural nitrogen use and loss respond to climate change on temporal and spatial scale is rarely understood. Here we show that climate change leads to small temporal but substantial spatial changes in cropland nitrogen use and losses across global regions based on historical data for the period 1961-2018 from 150 countries. Increases of yield, nitrogen surplus and nitrogen use efficiency (NUE) are identified in 24% of countries, while reductions are observed for the remaining 76% of countries, as a result of climate change in 2018. Changes of cropland area per capita of rural population (CAPRP) further intensify the variations of nitrogen use and pollution in global croplands. Yet, improving farmers’ practices with changes of CAPRP can facilitate climate change adaptation, by which global cropland NUE could be increased by one-third in 2100 compared to 2018 under future shared socioeconomic pathways. Our results would be of great significance to sustain global agriculture as well as eliminate national inequalities on food production and agricultural pollution control.
A novel immune checkpoint score system for prognostic evaluation in pancreatic adenocarcinoma
Authors: Chen Yusheng , Lin Xuan , Zou Xuan , Qian Yunzhen , Liu Yu , Wang Ruijie , Wang Xu , Yu Xianjun , Liu Chen , Cheng He 
Published: July 2022

Abstract
Pancreatic adenocarcinoma (PAAD) remains a lethal malignancy making the detection of novel prognostic biomarkers urgent. Limited studies have investigated the predictive capability of immune checkpoints in PAAD. Here, we presented a risk score system based on three immune checkpoints (OX40/TNFRSF4, TNFSF14 and KIR3DL1) through LASSO and Cox regression analyses for prognostic prediction. The risk score model was an independent prognostic factor and performed well regarding overall survival (OS) predictions among PAAD patients. A nomogram was established to facilitate the risk model application in clinical prognosis. Immune cells including naive B cells, CD8+ T cells and Tregs were negatively correlated with the risk score. Additionally, the risk score was associated with expression of immune checkpoint genes, immunogenic cell death related genes and somatic mutations. Glycolysis processes, IL-2-STAT5, IL-6-STAT3, and mTORC1 signaling pathways were enriched in the high-risk score group. Furthermore, scRNA-seq data confirmed that TNFRSF4, TNFSF14 and KIR3DL1 were expressed on immune cells in PAAD samples. We then identified OX40 as an independent prognosis-related gene, and a higher OX40 expression was associated with increased survival rate and immune environment change. In 84 PAAD clinical specimens collected from our center, we confirmed that higher OX40 mRNA expression levels were related to a good prognosis. The protein expression of OX40 on tumor-infiltrating immune cells (TIICs), endothelial cells and tumor cells was verified in PAAD tissues by immunohistochemistry (IHC) method. Overall, our findings strongly suggested that the three-immune checkpoint score system might be useful in the prognosis and design of personalized treatments for PAAD patients. Finally, we identified OX40 as an independent potential biomarker for PAAD prognosis prediction.
Efficacy and effectiveness of case isolation and quarantine during a growing phase of the COVID-19 epidemic in Finland
Authors: Auranen Kari , Shubin Mikhail , Erra Elina , Isosomppi Sanna , Kontto Jukka , Leino Tuija , Lukkarinen Timo 
Published: July 2022

Abstract
Based on data collected as part of the contact tracing activity of the City of Helsinki Epidemiological Operations Unit, we evaluated the efficacy and effectiveness of isolating SARS-CoV-2 cases and quarantining their exposed contacts during a mildly growing phase of the COVID-19 epidemic in Finland in autumn 2020. Based on the observed symptom-to-symptom intervals in 1016 pairs of primary and secondary cases, we estimated that without case isolation or quarantine 40% (90% credible interval, CI 25-59) of transmission would have occurred on the day of or after symptom onset. One third of SARS-CoV-2 cases (N =1521) had initially been quarantined, with a self-reported time until isolation (quarantine) of 0.8 days before symptom onset. This delay translates into an efficacy of 50% (90% CI 40-63) of averting secondary infections per quarantined case. Due to later isolation (mean 2.6 days after symptoms), the efficacy was smaller (24%; 90% CI 12-41) in those two third of the cases (N =3101) whose isolation was prompted by their symptoms, i.e. without being previously quarantined. At the population level, we evaluated the effectiveness of case isolation and quarantine on the growth rate of the COVID-19 epidemic in the autumn of 2020. Under a wide range of underlying assumptions, the rate would have been at least 2 times higher without case isolation and quarantine. The numbers needed to isolate or quarantine to prevent one secondary case were 2 and 20, respectively.
VMPS: A Vector Map Protection Framework Supporting Dynamic Game and Local Desensitization
Authors: Hua Weihua , Xu Heng , Duan Jianchao , Song Jun , Yang Fan 
Published: July 2022

Abstract
Secure sharing of geospatial information has attracted widespread attention in recent years. As a typical geospatial data, vector maps can be used in many fields of national economic and social development. However, there are many security threats to data sharing of vector digital map, such as tampering, forgery, infringement, data leakages. Due to the complex spatial relation nature, existing data protection solutions are either infeasible or ineffective in such scenarios, especially for the exchange, sharing, and publishing of map data. To address these real security problems, in this paper, we propose a novel vector map protection framework, which introduces the idea of dynamic game and local desensitization. Two basic models and a specific scheme, including an important information protection model, an optimal data desensitization model, and a game-based local desensitization scheme, are presented in this framework. Dynamic game strategies can be used to effectively measure the utility of players under different decisions. Furthermore, important or sensitive map elements in vector maps can be desensitized locally in a controlled and reversible manner , thereby achieving more efficient data protection and secure sharing. A comprehensive evaluation, including desensitization strategies, performance and time consumption, accuracy control and reversibility, is given to show the security and feasibility of the proposed framework.
The impacts of fibre pollution on fish host-parasite interactions
Authors: MacAulay Scott , Masud Numair , Ward Benjamin D. , Cable Jo 
Published: July 2022

Abstract
Plastic pollution is now a ubiquitous feature of freshwater systems and the majority of this is fibrous. Here, we test the effects of plastic and cellulose-based fibres (polyester, cotton, and bamboo from commercial clothing) on fish host-parasite interactions using a freshwater fish host-parasite model system (Guppy Poecilia reticulata-Gyrodactylus turnbulli). For uninfected fish, polyester exposure was associated with significantly higher mortality rates compared with the other two fibre types. For infected fish, while polyester and cotton exposure were not associated with any significant changes to parasite burdens, fish exposed to bamboo fibres had significantly reduced maximum parasite burdens compared with fish not exposed to any fibres, indicating that the bamboo fibres and/or associated dyes conferred some degree of resistance. While unable to determine the exact nature of the chemical dyes, when testing off-host parasite survival on exposure to the fibre dyes, cotton and particularly polyester dyes were associated with higher parasite mortality compared to bamboo. Overall, we add to the growing body of evidence which shows that fibrous microplastics and associated dyes can be detrimental for fish health, and we highlight the need for increased transparency from textile industries on the chemical identity of fabric dyes.
Filon-Clenshaw-Curtis Quadrature with Automatic Tone Removal
Authors: Milovich David 
Published: July 2022

Abstract
We present an adaptive method of computing finite Fourier integrals $\int_a^b f(x)g(x)e^{i\omega x}dx$ for smooth $f$ and smooth nonzero $g$, intended for the case where $g$ is highly and irregularly oscillatory, but $f$, $\abs{g}$, and $(\arg(g))'$ are not highly oscillatory. Our method easily extends to real-valued integrals $\int_a^bf(x)\cos h(x)\cos(\omega x)dx$ where $h$ is smooth, with the intention that $h$ is not highly oscillatory but $\cos h$ is. We do not require any special information about $f$ or $g$, just the ability to evaluate $f$, $g$, and $g'$ at arbitrary points. Our basic step per subinterval is to integrate $h(x)e^{i(\omega+m)x}$ where $m$ is the slope of $\arg(g)$ at the subinterval center and $h(x)$ is a Chebyshev polynomial interpolation of $f(x)g(x)e^{-imx}$. Thus, a tone is factored out to improve Chebyshev interpolation accuracy. We also investigate a second-order extension in which a chirp is factored out. An implementation of this paper's algorithms in the Julia programming language is publicly available.
Safety, tolerability, and pharmacokinetics of fluoropezil (DC20), a novel AChE inhibitor: a single-center, phase I study in healthy young and elderly Chinese subjects
Authors: Qian Hongjie , Yu Chengyin , Zhu Huijuan , Ding Qichen , Cai Yuting , Jing Jiao , Xu Xin , Guo Runcong , Zhang Haiyan , Liu Hong , Chen Xiaoyan , Liu Yun 
Published: July 2022

Abstract
Background
Acetylcholinesterase (AChE) inhibitors attempt to reduce the breakdown of acetylcholine levels in the brain of patients with Alzheimer’s disease (AD) by inhibiting the responsible enzyme AChE in the synaptic cleft. This study evaluated the safety, tolerability, and pharmacokinetics of fluoropezil (DC20), a novel AChE inhibitor under development for the treatment of AD in healthy young and elderly Chinese subjects.
Methods
The study on young subjects were divided into two arms: the multiple ascending-dose (MAD) arm (double-blind, randomized, placebo-controlled, multiple ascending-dose, 2 and 6 mg, N = 24), and the food effect arm (three-period, self-crossover, open-labeled, fasting/standard diet/high-fat diet administration, 4 mg, N = 12). A two-period, self-crossover, open-labeled, single ascending-dose study was designed for elderly subjects (2 and 4 mg, N = 11).
Results
For young subjects’ study: In the MAD arm, the accumulation ratios of DC20 in vivo were 2.29 and 2.15, respectively. In the food effect arm, compared with fasting administration, area under the concentration-time curve from zero to t (AUC0-t) orally after a standard diet and high-fat diet slightly increased by about 19% and 29% and the Tmax were delayed by around 1 hour. For elderly subjects’ study, Tmax were 1.5 and 1.25 hour, t1/2 were 77.1 and 74.2 hour, respectively. After oral administration of DC20 in healthy young and elderly subjects, no serious adverse events occurred, the most common adverse events associated with the study drug were gastrointestinal reactions.
Conclusion
We predicted the safety risks of DC20 in the clinical treatment of AD, which were well tolerated by the healthy young and elderly subjects. The elimination of DC20 from the body was slower in elderly subjects than in young subjects.
Trial registration numbers:
CTR20181428, CTR20190664, CTR20191878, CTR20192724 approved by the Center for Drug Evaluation, National Medical Products Administration.
The survey in the role of LAG3+ tumor-infiltrating lymphocytes in colorectal cancer prognosis; Relationship with sidedness
Authors: Tavana Shirin , Sanei Mohammad Hossein , Mokhtari Zahra , Heidari Zahra , Faghih Zahra Sadat , Rezaei Marzieh 
Published: July 2022

Abstract
Background: The interplay between tumor-infiltrating lymphocytes (TILs) and tumor cells is a major determining factor in cancer progression. CD45RO seems to be a reliable indicator for predicting prognosis and disease outcome, along with CD3 and CD8 markers. LAG-3 is another important marker that overexpresses on TILs in a variety of cancers and is associated with disease prognosis; however, its prognostic impact is controversial. Hence, in the present study, we aimed to investigate the presence of CD45RO+, LAG3+, CD3+, and CD8+ lymphocytes in CRC tumor tissues and their association with clinicopathological parameters of the disease as well as patients' survival, according to primary tumor locations.Methods: Expression of CD45RO, LAG3, CD3, and CD8 was Immunohistochemically analyzed in tissue sections from 136 patients with CRC. The percentage of TILs expressing these markers were separately determined in the invasive margin (IM) and center of the tumor (CT). Their associations with clinical factors and survival were analyzed in the entire cohort, and in the subgroups of patients with right and left/rectum tumors.Results: Based on our observation, CD45RO+ and CD3+ lymphocytes were the most frequent infiltrated cells in both CT and IM regions of colon tumor tissue. On the other hand, LAG3+ lymphocytes were the least frequent subset in both areas. In univariate analysis, high score of CD45RO in IM was associated with better overall survival in the entire cohort. High score of CD8 and CD45RO in IM were also associated with improved overall survival in right-sided tumors. However, CD45RO expression correlated with advanced TNM stages (III/IV), in the entire cohort and in right-sided tumors. In the case of LAG3, although the association between the expression of this marker and survival was not found, LAG3+ TILs in CT were associated with higher T-stages in the entire cohort.Conclusions: Our findings suggest that the clinicopathological and prognostic significance of immune system-related markers such as CD45RO and LAG3 depends on the primary tumor sides. Our results collectively demonstrated that infiltration of CD45RO+ lymphocytes in IM could be an independent prognostic factor in a site-dependent manner.
An Improved Target Tracking Scheme based on MC-MPMC Method for Mobile Wireless Sensor Networks
Authors: Lv Chunfeng , Zhu Jianping , Tao Zhengsu 
Published: July 2022

Abstract
Target tracking is crucial to many applications in wireless sensor networks (WSNs). Existing tracking schemes used in WSNs can basically be classified two categories, clustering and predicting. Considering network clustering consumes much energy for limited-energy WSNs, a predicting target tracking scheme is proposed called MC-MPMC (Measurement Compensation based Mixture Population Monte Carlo) method which tracks the target based on predicted locations in this work. Adaptive mixture PMC model for generating proposals varying from each iteration is proposed to guarantee the sample diversity. And also, extra measurements or observations generating method is introduced to compensate missing predict locations or false estimations, avoiding tracking behavior degradation. Firstly, samples drawn from the proposals of next iteration can generated by a mixture method to avoid sample degeneracy. Secondly, sample weights are jointly computed based on adaptive fusion of compensation measurement and true measurements. Thirdly, the HTC method is combined to MC-MPMC scheme to decrease energy consumption in WSNs. Then, the proposed method is verified through comprehensive experiments about tracking error, delay and consumption predictions. Moreover, performance comparisons of MC-MPMC with other tracking schemes are also proposed.