bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world evidence of biologic treatments in psoriatic arthritis in Italy: results of the CHRONOS (EffeCtiveness of biologic treatments for psoriatic artHRitis in Italy: an ObservatioNal lOngitudinal Study of real-life clinical practice) observational longitudinal study
Authors: Colombo Delia , Frassi Micol , Pagano Mariano Giusy , Fusaro Enrico , Lomater Claudia , Del Medico Patrizia , Iannone Florenzo , Foti Rosario , Limonta Massimiliano , Marchesoni Antonio , Raffeiner Bernd , Viapiana Ombretta , Grassi Walter , Grembiale Rosa Daniela , Guggino Giuliana , Mazzone Antonino , Tirri Enrico , Perricone Roberto , Sarzi Puttini Pier Carlo , De Vita Salvatore , Conti Fabrizio , Ori Alessandra , Simoni Lucia , Fiocchi Martina , Orsenigo Roberto , Zagni Emanuela ,   and the CHRONOS Study Group, Frassi Micol , Caminiti Maurizio , Fusaro Enrico , Lomater Claudia , Del Medico Patrizia , Iannone Florenzo , Foti Rosario , Limonta Massimiliano , Marchesoni Antonio , Raffeiner Bernd , Viapiana Ombretta , Grassi Walter , Grembiale Rosa Daniela , Guggino Giuliana , Mazzone Antonino , Tirri Enrico , Perricone Roberto , Puttini Pier Carlo Sarzi , De Vita Salvatore , Conti Fabrizio 
Published: September 2022

Abstract
Background
Biologics have demonstrated efficacy in PsA in randomized clinical trials. More evidence is needed on their effectiveness under real clinical practice conditions. The aim of the present work is to provide real-world evidence of the effectiveness of biologics for PsA in the daily clinical practice.

Methods
CHRONOS was a multicenter, non-interventional, cohort study conducted in 20 Italian hospital rheumatology clinics.

Results
399 patients were eligible (56.9% females, mean (SD) age: 52.4 (11.6) years). The mean (SD) duration of PsA and psoriasis was 7.2 (6.9) and 15.3 (12.2) years, respectively. The mean (SD) duration of the biologic treatment under analysis was 18.6 (6.5) months. The most frequently prescribed biologic was secukinumab (40.4%), followed by adalimumab (17.8%) and etanercept (16.5%). The proportion of overall responders according to EULAR DAS28 criteria was 71.8% (95% CI: 66.7–76.8%) out of 308 patients at 6 months and 68.0% (95% CI: 62.7–73.3%) out of 297 patients at 1 year. Overall, ACR20/50/70 responses at 6 months were 41.2% (80/194), 29.4% (57/194), 17.1% (34/199) and at 1-year were 34.9% (66/189), 26.7% (51/191), 18.4% (36/196), respectively. Secondary outcome measures improved rapidly already at 6 months: mean (SD) PASI, available for 87 patients, decreased from 3.2 (5.1) to 0.6 (1.3), the proportion of patients with dactylitis from 23.6% (35/148) to 3.5% (5/142) and those with enthesitis from 33.3% (49/147) to 9.0% (12/133).

Conclusions
The CHRONOS study provides real-world evidence of the effectiveness of biologics in PsA in the Italian rheumatological practice, confirming the efficacy reported in RCTs across various outcome measures.
Antithrombotic treatment and outcome after endovascular treatment and acute carotid artery stenting in stroke patients with atrial fibrillation
Authors: Weller Johannes M. , Dorn Franziska , Meissner Julius N. , Stösser Sebastian , Beckonert Niklas M. , Nordsiek Julia , Kindler Christine , Riegler Christoph , Keil Fee , Petzold Gabor C. , Bode Felix J. ,   the GSR-ET investigators, Reich A. , Nikoubashman O. , Röther J. , Eckert B. , Braun M. , Hamann G. F. , Siebert E. , Nolte C. H. , Bohner G. , Eckert R. M. , Borggrefe J. , Schellinger P. , Berrouschot J. , Bormann A. , Kraemer C. , Leischner H. , Petersen M. , Stögbauer F. , Boeck-Behrens T , Wunderlich S. , Ludolph A. , Henn K. H. , Gerloff C. , Fiehler J. , Thomalla G. , Alegiani A. , Schäfer J. H. , Tiedt S. , Kellert L. , Trumm C. , Ernemann U. , Poli S. , Liman J. , Ernst M. , Gröschel K. , Uphaus T. 
Published: September 2022

Abstract
Background
Oral anticoagulation (OAC) is the mainstay of secondary prevention in ischemic stroke patients with atrial fibrillation (AF). However, in AF patients with large vessel occlusion stroke treated by endovascular therapy (ET) and acute carotid artery stenting (CAS), the optimal antithrombotic medication remains unclear.

Methods
This is a subgroup analysis of the German Stroke Registry—Endovascular Treatment (GSR-ET), a prospective multicenter cohort of patients with large vessel occlusion stroke undergoing ET. Patients with AF and CAS during ET were included. We analyzed baseline and periprocedural characteristics, antithrombotic strategies and functional outcome at 90 days.

Results
Among 6635 patients in the registry, a total of 82 patients (1.2%, age 77.9 ± 8.0 years, 39% female) with AF and extracranial CAS during ET were included. Antithrombotic medication at admission, during ET, postprocedural and at discharge was highly variable and overall mortality in hospital (21%) and at 90 days (39%) was high.
Among discharged patients (n = 65), most frequent antithrombotic regimes were dual antiplatelet therapy (DAPT, 37%), single APT + OAC (25%) and DAPT + OAC (20%). Comparing DAPT to single or dual APT + OAC, clinical characteristics at discharge were similar (median NIHSS 7.5 [interquartile range, 3–10.5] vs 7 [4–11], p = 0.73, mRS 4 [IQR 3–4] vs. 4 [IQR 3–5], p = 0.79), but 90-day mortality was higher without OAC (32 vs 4%, p = 0.02).

Conclusions
In AF patients who underwent ET and CAS, 90-day mortality was higher in patients not receiving OAC.
Registration: https://www.clinicaltrials.gov; Unique identifier: NCT03356392.
Association between social support and pregnancy stress: a cross-sectional study of neighbors’ interactions
Authors: Abdi Sadaf , Faramarzi Mahbobeh , Bouzari Zinatossadat , Chehrazi Mohammad , Esfandyari Maria 
Published: September 2022

Abstract
Background
Pregnancy is associated with substantial stressful experiences. There are controversies concerning the positive and negative roles of social support during pregnancy. This research aimed to study the association of social support with the pregnancy-related stress.

Methods
In the current cross-sectional research, 200 pregnant women were recruited through convenience sampling from two teaching hospitals affiliated with Babol University of Medical Sciences and a private obstetric clinic. The women completed two self-reported questionnaires during prenatal care appointments. The questionnaires included the Revised Prenatal Distress Questionnaire (NuPDQ) and Social Support Questionnaire (SSQ).

Results
A significantly positive association was observed between the social support of neighbors and the total score of pregnancy stress (P<0.001), as well as the scores of its four subscales, namely medical problems (P<0.001), parenting (P=0.25), infant health stress (P=0.006), and pregnancy symptoms (P=0.001). Based on the linear regression models, the social support of neighbors was significantly related to the medical problem-associated stress in pregnant women (β = 0.147, 95% CI: 0.14 to 0.62, p = 0.047), pregnancy symptom (β = 0.203, 95% CI: −0.01 to 0.327, p = 0.017), and fear of childbirth (β = 0.164, 95% CI: 0.05 to 0.38, p = 0.046). Furthermore, the neighbors’ social support (β = 0.172, 95% CI: 0.02 to 0.32, p = 0.04) and the total score of social support (β = 0.155, 95% CI: 0.01 to 0.304, p = 0.046) were significantly associated with the total score of pregnancy stress.

Conclusions
Neighbors’ support, as a component of social support, was found to be significantly related to pregnancy stress. This study recommends that healthcare providers consider the positive and negative impacts of social support during the pregnancy period.
Computational analysis of G-protein-coupled receptor kinase family members as potential targets for colorectal cancer therapy
Authors: Hermawan Adam , Putri Herwandhani 
Published: September 2022

Abstract
Background
G-protein-coupled receptor (GPCR) kinases (GRKs) interact with ligand-activated GPCR, causing intracellular phosphorylation and interfering with the intracellular signal transduction associated with the development of cancer. Colorectal cancer (CRC) is a fast-growing disease, and its molecular mechanism involves various regulatory proteins, including kinases. However, the GRK mechanism in CRC has not been explored.

Methods
We used an integrated computational approach to investigate the potential of GRK family members as targeted proteins in CRC. The GRK expression levels in tumor and normal tissues, colon adenocarcinoma samples, and metastatic colon adenocarcinoma were analyzed using ONCOMINE, GEPIA, and UALCAN, as well as TNM plots. Genetic changes in the GRK family genes were investigated using cBioportal. The prognostic value related to the gene expression of the GRK family was examined using GEPIA and UALCAN. Co-expression analysis of the GRK family was conducted using COXPRESdb. Association analysis of the Gene Ontology, KEGG pathway enrichment, and drug-gene analyses were performed using the over-representation analysis (ORA) in WebGestalt.

Results
GRK2, GRK3, and GRK5 mRNA levels increased significantly in patients with CRC and metastatic CRC. Genetic changes were detected in patients with CRC, including GRK7 (1.1%), GRK2 (1.7%), GRK4 (2.3%), GRK5 (2.5%), GRK6 (2.5%), GRK3 (2.9%), and GRK1 (4%). CRC patients with low mRNA of GRK7 levels had better disease-free and overall survival than those with high GRK7 levels. Hierarchical clustering analysis revealed significant positive correlations between GRK5 and GRK2 and between GRK2 and GRK6. KEGG pathway enrichment analysis showed that the gene network (GN) regulated several cellular pathways, such as the morphine addiction signaling and chemokine signaling pathways in cancer. The drug-gene association analysis indicated that the GN was associated with several drugs, including reboxetine, pindolol, beta-blocking agents, and protein kinase inhibitors.

Conclusion
No research has been conducted on the relation of GRK1 and GRK7 to cancer, particularly CRC. In this work, genes GRK2, GRK3, GRK5, and GRK6 were found to be oncogenes in CRC. Although inhibitors against GRK2, GRK5, and GRK6 have previously been developed, further research, particularly preclinical and clinical studies, is needed before these agents may be used to treat CRC.
Impact of paediatric intensive care unit admission on neurocognitive function in children
Authors: Zaitoun Raghda , Aly Rasha Hussein , Rezk Ahmed R. 
Published: September 2022

Abstract
Background
Advances in paediatric critical care have resulted in a reduction in mortality. This has shifted the focus to paediatric intensive care unit (PICU)-related morbidities and how to reduce or prevent them. In this study, we aimed to study the impact of paediatric intensive care unit (PICU) admission on neurocognitive performance.

Methods
Intelligence quotient (IQ) was tested in 50 children (27 boys, 23 girls; mean age 6.98 years) 3 months after PICU discharge and in 75 controls using the Stanford-Binet IQ test.

Results
There was no statistically significant difference between patients and controls with regard to IQ scores, and no difference between medical and surgical patients (p > 0.05). IQ was unaffected by sedation, blood transfusion, or blood product transfusion. Patients who underwent a major surgical procedure, needed inotropic support, and needed mechanical ventilation had non-significantly lower IQ scores than those who did not. A non-significant negative correlation was observed between the length of PICU stay, mechanical ventilation duration, sedative use, and inotropic support.

Conclusions
PICU admission does not appear to significantly affect cognitive outcomes in paediatric survivors.
Medication-related burden among Iraqi patients with rheumatoid arthritis: An observational study
Authors: Kadhim Jwad Rwnk , Jabbar Kadhim Dheyaa , Hadi Munshed Alosami Mohammed , G. Shareef Laith 
Published: September 2022

Background: Rheumatoid arthritis (RA) is a chronically progressing inflammatory disease having articular, extra-articular, and systemic manifestations of unclear origin. Medication-related burden (MRB) is a novel concept that focuses on unpleasant feelings associated with the therapeutic process. The purpose of this research was to examine MRB among Iraqi patients with rheumatoid arthritis from the patient's viewpoint. Methods: The present research was a cross-sectional study conducted on patients with rheumatoid arthritis who had previously been diagnosed and visited Baghdad Teaching Hospital/Medical City/Rheumatology department between December 2021 through March 2022. The Living with Medicines Questionnaire was used to assess MRB (LMQ). Results: The study recruited 250 RA patients. The average age of the patients was 47.29± 12.72 years. The vast majority were women, 80.8%. The mean LMQ score was 113.78± 13.95. Most participants experienced a moderate degree of burden of 72.0%, followed by a minimum commitment of 24.4%, a high burden of 2.8%, and no burden of 0.8%, with no patient experiencing a high burden of 0 %. Women had significantly higher medication-related burdens (total LMQ). RA patients with more than five chronic medications had substantially higher MRB than those with fewer scheduled medications. Patients with chronic diseases (other than RA) had significantly higher MRB than those without other chronic diseases. The total LMQ score had a significant positive correlation with the Clinical Disease Activity Index (CDAI) value. In other words, when disease severity increases, the MRB increases. Conclusion: A considerable proportion of the RA patients involved in the current study have experienced MRB. Female sex, polypharmacy, comorbidities, and more severe disease are associated with more MRB.
Radiotherapy in the comprehensive treatment of rectal cancer
Authors: Luts B. 
Published: September 2022

Introduction. A favorable outcome of the treatment of patients with rectal cancer in the early stages is not a difficult task, as it is easily solved thanks to only surgical intervention. The biggest problem is the treatment of patients with late-stage (III and IV) rectal cancer. The use of radiation therapy is an integral niche in the complex treatment of rectal cancer. Complete or partial clinical response of the tumor to neoadjuvant therapy is a favorable factor that correlates with an increase in overall and recurrence-free survival of patients with rectal cancer.
Aim. To conduct an analysis of the effectiveness of radiotherapy and neoadjuvant chemoradiotherapy in the complex treatment of rectal cancer based on the results of the tumor's clinical response to the treatment.
Research results. In both groups of patients, the tumor was localized in the middle ampullary part of the rectum in 52.6% of the main group and 55.4% of the control group. In the lower ampullary section of the rectum in 22 patients of the main group (38.6%) and in 22 (39.3%) of the control group, respectively. The number of patients with tumor localization in the upper ampullary region was 5 (8.8%) and 35 (5.3%), respectively. Positive dynamics in the form of replacement of tumor tissue by fibrosis was observed in 89 (78.7%) patients in the compared groups. A complete clinical response was noted in 2 (3.5%) patients in the main group and in 1 (1.8%) in the control group. In 86 patients in the compared groups, II and III degrees of tumor regression according to TRG grading were recorded in 43 (75.4%) patients in the main group and 43 (76.8%) in the control group.
Conclusions. In both groups, the tumor was most often localized in the middle ampullary part of the rectum, 52.6% in the main group and 55.4% of the control group. Positive dynamics in the form of replacement of tumor tissue by fibrosis was observed in 89 (78.7%) patients in the compared groups. A complete clinical response was noted in 2 (3.5%) patients in the main group and in 1 (1.8%) in the control group. Unsatisfactory dynamics in the form of IV and V degrees of tumor regression according to the TRG grading were noted in 12 (21.05%) patients of the main group and in 12 (21.4%) - in the control group.
A cross-sectional retrospective study comparing handwritten operation notes with electronic operation notes
Authors: Ekowo O , Hammenga C , Altaf K , Chan K , Bhardwaj R , Nada H 
Published: September 2022

Introduction Electronically completed medical notes have been shown to be superior in legibility and completeness to handwritten ones. Despite this, surgeons continue to use handwritten operation notes. This paper aims to compare the quality of handwritten versus electronic operation notes. Methods This is a retrospective cross-sectional single-centre study done at Darent Valley Hospital, a district general hospital at Dartford, UK. We looked at 405 operation notes of patients who had general surgery procedures between 1 January 2020 to 31 January 2021 checking for legibility and completeness of operation note criteria as given by the Royal College of Surgeons of England’s Good Surgical Practice. Data were collated using an app that populates comparison criteria in an Excel sheet and were analysed using SPSS (Statistical Package for the Social Sciences). The results are presented in bar graphs and frequency table. Results In 17 out of the 18 criteria in RCS England’s Good Surgical Practice, electronic notes were better completed than handwritten ones (p<0.001). Signature as a criterion had comparable level of completeness in both handwritten and electronic notes, 95% versus 91% respectively. There was 8.3% illegibility in the handwritten note and none in the electronic ones. Conclusions Electronic notes are far better completed than handwritten notes in 17 out of the 18 criteria of a good operation note by RCS England. The difference between both forms of notes is far too much; we propose a complete shift in practice from handwritten to electronic format.
Phonetic stability across time: Linguistic enclaves in Switzerland
Authors: Büchler Andrin , Leeman Adrian 
Published: September 2022

The present paper shows results of a proof-of-concept study on two historically related but geographically separated dialects of Swiss German. Between the 12th and 14th centuries, speakers of Valais German (southwestern Switzerland) emigrated to the southeastern part of the country, forming so-called Sprachinseln (enclaves) of Valais German in a Romansh-speaking area. Using an online survey, we collected responses from 300+ participants from the cantons of Valais and Grisons to examine how the two dialects have developed over time. Results suggest stability on the phonetic level, i. e. the two dialects still sound very similar despite having been geographically separated for 800 years. The morphosyntax and lexicon, however, exhibit substantial change. We discuss historic and sociodemographic factors that may explain these patterns.
Looking at the periphery from the suburbs: An information-structurally based taxonomy of Hanging Topics in German
Authors: Catasso Nicholas 
Published: September 2022

In this paper, it is proposed on the basis of data from German that some of the information-structural features encoded by the projections located in the clause-internal Split-CP domain in the Rizzian (1997) model are replicated in the so-called “outer left periphery”, i. e. in the area situated above ForceP. In doing this, I pursue a cartographic approach in which information structure is directly represented in the syntax by means of syntactic heads that project within the clausal left periphery. The main claim of the paper is that the outer left periphery (of German) includes dedicated projections for four classes of topics, namely so-called “Contrastive Hanging Topics”, “Aboutness Contrastive Topics”, “Familiar Hanging Topics” and “Frame-setting Hanging Topics”. The observations made in this paper pave the way for a comparison with other languages, as well as for the question of the universality of this clause-peripheral makeup.
Towards an agnotology of policy studies: identifying, understanding and addressing knowledge limitations in real world policymaking
Authors: Howlett Michael 
Published: September 2022

Background:This comment responds to points raised in Hannah et al (2023).
Aims and objectives:The commentary frames the Hannah et al discussion within other recent moves in the policy field to take ‘non-knowledge’ more seriously.
Methods:The commentary situates the Hannah et al discussion within the traditional literature on knowledge utilisation in the public policy literature.
Findings:It is argued that while the Hannah et al article is an advance in thinking in the field it does not deal adequately with earlier efforts and findings in the literature.
Discussion and conclusion:More work towards ‘An agnotology of the policy studies’ is needed.
Clinical usefulness of the pattern of non-adherence to anti-platelet regimen in stented patients (PARIS) thrombotic risk score to predict long-term all-cause mortality and heart failure hospitalization after percutaneous coronary intervention
Authors: Akama Joh , Shimizu Takeshi , Ando Takuya , Anzai Fumiya , Muto Yuuki , Kimishima Yusuke , Kiko Takatoyo , Yoshihisa Akiomi , Yamaki Takayoshi , Kunii Hiroyuki , Nakazato Kazuhiko , Ishida Takafumi , Takeishi Yasuchika 
Published: September 2022

Background
The Patterns of non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) thrombotic risk score has been proposed to estimate the risk of stent thrombotic events after percutaneous coronary intervention (PCI). However, the prognostic value of the PARIS thrombotic risk score for long term all-cause and cardiac mortalities, as well as hospitalization due to heart failure, has not yet been evaluated. Therefore, the aim of the present study was to evaluate the prognostic value of the PARIS thrombotic risk score for all-cause and cardiac mortalities and hospitalization due to heart failure following PCI.

Methods and results
Consecutive 1,061 patients who underwent PCI were divided into three groups based on PARIS thrombotic risk score; low- (n = 320), intermediate- (n = 469) and high-risk (n = 272) groups. We followed up on all three groups for all-cause mortality, cardiac mortality and hospitalization due to heart failure. Kaplan-Meier analysis showed that all outcomes were highest in the high-risk group (P < 0.001, P = 0.022 and P < 0.001, respectively). Multivariate Cox proportional hazard analysis, adjusted for confounding factors, showed that the risk of all-cause mortality and hospitalization due to heart failure of the high-risk group were higher than those of the low-risk group (hazard ratios 1.76 and 2.14, P = 0.005 and P = 0.017, respectively).

Conclusion
The PARIS thrombotic risk score is a significant prognostic indicator for all-cause mortality and hospitalization due to heart failure in patients after PCI.