bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stress-related disorders and subsequent cancer risk and mortality: a population-based and sibling-controlled cohort study in Sweden
Authors: Tian Fan , Fang Fang , Shen Qing , Ye Weimin , Valdimarsdóttir Unnur A. , Song Huan 
Published: August 2022

AbstractPrior research has suggested a potential role of psychological stress on cancer development while the role of familial factors on this association is underexplored. We conducted a nationwide cohort study including 167,836 individuals with a first-onset stress-related disorder (including post-traumatic stress disorder, acute stress reaction, adjustment disorder and other stress reactions) diagnosed between 1981 and 2016 in Sweden (i.e., exposed patients), 1,631,801 birth year- and sex-matched unexposed individuals, and 179,209 unaffected full siblings of the exposed patients. Cox models were used to estimate the hazard ratios (HRs) of newly diagnosed cancer and cancer-related death, beyond 1 year after diagnosis of stress-related disorders. We further examined the potential mediation roles of behavior-related morbidities in the associations of stress-related disorders with smoking or alcohol-related cancer incidence and mortality. We found modestly elevated risks of cancer incidence and mortality among exposed patients compared with matched unexposed individuals (incidence: HR = 1.03, 95% CI 1.01–1.06; mortality: HR = 1.13, 95% CI 1.07–1.18), while not when comparing with full siblings (incidence: HR = 1.03, 95% CI 0.99–1.08; mortality: HR = 1.09, 95% CI 1.00-1.19). Similarly, the suggested elevations in incidence and mortality of individual cancer sites (or groups) in the population-based comparison attenuated towards null in the between-sibling comparison. The risk elevations for smoking or alcohol-related cancers in the population-based comparison (incidence: HR = 1.18, 95% CI 1.11–1.24; mortality: HR = 1.20, 95% CI 1.12–1.29) were partially mediated by alcohol-related morbidities during follow-up. Collectively, our findings suggest that the association between stress-related disorders and cancer risk and mortality is largely explained by familial factors, including shared behavioral hazards.
A Survey on Adversarial Domain Adaptation
Authors: HassanPour Zonoozi Mahta , Seydi Vahid 
Published: August 2022

AbstractHaving a lot of labeled data is always a problem in machine learning issues. Even by collecting lots of data hardly, shift in data distribution might emerge because of differences in source and target domains. The shift would make the model to face with problems in test step. Therefore, the necessity of using domain adaptation emerges. There are three techniques in the field of domain adaptation namely discrepancy based, adversarial based and reconstruction based methods. For domain adaptation, adversarial learning approaches showed state-of-the-art performance. Although there are some comprehensive surveys about domain adaptation, we technically focus on adversarial based domain adaptation methods. We examine each proposed method in detail with respect to their structures and objective functions. The common aspect of proposed methods besides domain adaptation is considering the target labels are predicted as accurately as possible. It can be represented by some methods such as metric learning and multi-adversarial discriminators as are used in some of the papers. Also, we address the negative transfer issue for dissimilar distributions and propose the addition of clustering heuristics to the underlying structures for future research.
Metabolomic changes in cats with renal disease and calcium oxalate uroliths
Authors: Jewell Dennis E. , Tavener Selena K. , Hollar Regina L. , Panickar Kiran S. 
Published: August 2022

AbstractIntroductionThere is a significant incidence of cats with renal disease (RD) and calcium oxalate (CaOx) kidney uroliths in domesticated cats. Foods which aid in the management of these diseases may be enhanced through understanding the underlying metabolomic changes.ObjectiveAssess the metabolomic profile with a view to identifying metabolomic targets which could aid in the management of renal disease and CaOx uroliths.MethodThis is a retrospective investigation of 42 cats: 19 healthy kidney controls, 11 with RD, and 12 that formed CaOx nephroliths. Cats were evaluated as adults (2 through 7 years) and at the end of life for plasma metabolomics, body composition, and markers of renal dysfunction. Kidney sections were assessed by Pizzolato stain at the end of life for detection of CaOx crystals. CaOx stone presence was also assessed by analysis of stones removed from the kidney at the end of life.ResultsThere were 791 metabolites identified with 91 having significant (p < 0.05, q < 0.1) changes between groups. Many changes in metabolite concentrations could be explained by the loss of renal function being most acute in the cats with RD while the cats with CaOx stones were intermediate between control and RD (e.g., urea, creatinine, pseudouridine, dimethylarginines). However, the concentrations of some metabolites differentiated RD from CaOx stone forming cats. These were either increased in the RD cats (e.g., cystathionine, dodecanedioate, 3-(3-amino-3-carboxypropyl) uridine, 5-methyl-2′-deoxycytidine) or comparatively increased in the CaOx stone forming cats (phenylpyruvate, 4-hydroxyphenylpyruvate, alpha-ketobutyrate, retinal).ConclusionsThe metabolomic changes show specific metabolites which respond generally to both renal diseases while the metabolomic profile still differentiates cats with RD and cats with CaOx uroliths.
Assessing the carbon footprint of a Colombian University Campus using the UNE-ISO 14064–1 and WRI/WBCSD GHG Protocol Corporate Standard
Authors: Cano Natalia , Berrio Linda , Carvajal Elizabeth , Arango Santiago 
Published: August 2022

Abstract
Higher education institutions (HEIs) transfer skills and knowledge between industries, the government, and the public, playing a vital role at educating future leaders in creating a globally sustainable system. Therein, evaluating greenhouse gas emissions from an educational institute is the first step towards the proposed reduction targets at the local, national, and international levels. In this research, we report the first approximate carbon footprint calculation of emissions corresponding to scope 1, scope 2, and scope 3 emissions for the main urban campuses of Universidad Nacional de Colombia, Medellín, using the UNE-ISO 14064–1 and WRI/WBCSD GHG Protocol Corporate standard. The carbon footprint in 2019 was approximately 7250.52 tons CO2 eq, and 0.432 tons CO2 eq per person. Scope 1 emissions accounted for about 2.84% of the carbon footprint, while scope 2 and 3 emissions each contributed nearly 14% and 83%, respectively. The largest sources of greenhouse gas emissions were the transportation process (58.51%), the wastewater process (17.01%), followed by electricity consumption (14.03%), and the e-mails that are sent (6.51%). It is suggested some proposals and strategies for mitigating and reducing emissions. Colombian HEIs exhibit the lowest ton of CO2 eq. per person compared to the other HEIs. Several reasons explain this behavior across the document such as geographic location (climate and topography), cultural factors (consumption patterns and types of transportation), population size, typology (public or private), gross domestic product (GDP) of each country, and methodology implemented. Results cannot be extrapolated to the Colombian case for the differences in the local conditions; therefore, it is not possible to get solid conclusions on the CF behavior in the Colombian HEIs. In this research, we provide for the first time a carbon footprint calculation where the sociological, political, and geographic conditions not extrapolated representing a valuable contribution to the HEI’s of the country. This research can be a benchmark in the carbon footprint calculation and a methodological contribution to HEIs in the country.
Von den kreativen Künstlersubjekten Jakob Levy Moreno und Joseph Beuys zum Kreativsubjekt in den Gegenwartsgesellschaften
Authors: Marschall Brigitte 
Published: August 2022

ZusammenfassungDieser Artikel der Zeitschrift für Psychodrama und Soziometrie beschäftigt sich mit den Kreativitätskonzepten von Jakob Levy Moreno und Joseph Beuys und setzt sie in Bezug zueinander. Moreno als auch Beuys konstruierten sich mit ihren jeweiligen Kreativitätskonzepten als Künstlersubjekte. Mittlerweile kann Kreativität als Kulturtechnik in den Gegenwartsgesellschaften bezeichnet werden. Sämtliche Alltags- und Lebensbereiche werden in einen gesellschaftlichen Prozess der Ästhetisierung überführt. Dem vermehrt inflationären Gebrauch des Begriffs „Kreativität“ als Ware und Konsumgut sollen die Konzepte von Moreno und Beuys entgegengesetzt werden. Zu dieser Auseinandersetzung möchte dieser Beitrag anregen.
ALARA in Urology: Steps to Minimise Radiation Exposure During All Parts of the Endourological Journey
Authors: Bhanot Radhika , Hameed Zeeshan B. M. , Shah Milap , Juliebø-Jones Patrick , Skolarikos Andreas , Somani Bhaskar 
Published: August 2022

Abstract
Purpose of the Review
The global burden of kidney stone disease (KSD) and its management relies on ionising radiation. This includes the diagnosis, treatment and follow-up of KSD patients. The concept ‘As Low As Reasonably Achievable’ (ALARA) developed in response to the radiation risks and the key principles include optimisation, justification and limitation of radiation. This article provides an overview of the topic including background to the risks and steps that can be taken during all stages of endourological management.

Recent Findings
Our review suggests that ionising radiation is an invaluable tool in delineating the anatomy, localising disease, guiding manoeuvres and monitoring treatment in patients with KSD. It therefore plays an integral role in many stages of patient care; preoperatively, intraoperatively and postoperatively.
The reduction of radiation pre- and post-surgical intervention relies on the use of low-radiation CT scan and ultrasound scan. It can also be achieved through various intraoperative techniques or fluoroless techniques in selected patients/procedures, customised to the patients and procedural complexity.

Summary
There are many parts of the patient journey where exposure to radiation can take place. Urologists must be diligent to minimise and mitigate this wherever possible as they too face exposure risks. Implementation of strategies such as teaching programmes, fluoroscopy checklists and judicious use of CT imaging among other things is a step towards improving practice in this area.
Proportion of women in work teams and team performance: a moderated mediation model
Authors: Davcheva Marija , González-Romá Vicente 
Published: August 2022

AbstractWomen’s representation in the workforce is increasing. However, we still do not know how, why, and when the proportion of females in work teams is related to team performance. Based on Social Role Theory and Congruence Theory, the purpose of the study was to ascertain whether the relationship between the proportion of women in work teams and team performance is mediated by team social cohesion, and whether this indirect effect is moderated by the frequency of leader-team member social interactions. Regarding methodological aspects, the study sample was composed of 178 work teams from three banks. We implemented a time-lagged design and collected data from two distinct sources (team members and team leaders) at three different time points. Our findings indicate that the proportion of women in teams was positively related to team performance via team social cohesion. This indirect effect was moderated by the frequency of leader-team member social interactions, so that it was positive and statistically significant only in teams with medium and high frequency of these interactions. This study reveals that team social cohesion is a mechanism through which the proportion of women in work teams can facilitate team performance, especially when team leaders frequently interact with their team members. The theoretical and practical implications of our findings were discussed.
Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review
Authors: Fang Zhen , Ding Yixuan , Xue Zhigang , Li Peijuan , Li Jia , Li Fei 
Published: August 2022

AbstractExosomes can be released by a variety of cells and participate in intercellular communication in many physiological processes in the body. They can be used as carriers of cancer therapeutic drugs and have natural delivery capabilities. Some biologically active substances on exosomes, such as major histocompatibility complex (MHC), have been shown to be involved in exosome-mediated anticancer immune responses and have important regulatory effects on the immune system. Exosome-based drug delivery systems hold great promise in future cancer immunotherapy. However, there are still substantial challenges to be overcome in the clinical application of exosomes as drug carriers. This article reviews the biological characteristics of exosome drug delivery systems and their potential applications and challenges in cancer immunotherapy.
Dietary acrylamide and incident osteoporotic fractures: an 8-year prospective cohort study
Authors: Veronese Nicola , Bolzetta Francesco , Cacco Chiara , Cester Alberto , Smith Lee , Demurtas Jacopo , Cooper Cyrus , Rizzoli Renè , Caruso Maria Gabriella , Notarnicola Maria , Reginster Jean-Yves , Maggi Stefania , Barbagallo Mario , Trott Mike , Dominguez Ligia J. 
Published: August 2022

Abstract
Background
Acrylamide, a component of fried foods, has been associated with several negative health outcomes. However, the relationship between dietary acrylamide and osteoporotic fractures has been explored by a few cross-sectional studies.

Aims
To investigate if dietary acrylamide is associated with the onset of fractures in North American participants at high risk/having knee osteoarthritis (OA), over 8 years of follow-up.

Methods
A Cox’s regression analysis, adjusted for baseline confounders was run and the data were reported as hazard ratios (HRs) and 95% confidence intervals (CIs). Dietary acrylamide intake was assessed at the baseline using a food frequency questionnaire and categorized in tertiles (T), whilst fractures’ history was recorded using self-reported information.

Results
Altogether, 4,436 participants were included. Compared to participants with lower acrylamide intake (T1; < 3,313 μg), those with a higher acrylamide intake (T3; > 10,180 μg) reported a significantly higher risk of any fracture (HR = 1.37; 95% CI 1.12–1.68; p for trend = 0.009), forearm (HR = 1.73; 95% CI 1.09–2.77; p for trend = 0.04), spine (HR = 2.21; 95% CI 1.14–4.31; p for trend = 0.04), and hip fracture (HR = 4.09; 95% CI 1.29–12.96; p for trend = 0.046).

Conclusions
Our study is the first to report that high dietary acrylamide may be associated with an increased risk of osteoporotic fractures.
A Comparative Study of Fetal MRI and Antenatal Ultrasound in Prenatal Diagnosis with Histopathological Correlation
Authors: Patil Vikram , Tafheem Mohd , Melkundi Shivanand , Masimade Suresh 
Published: August 2022

AbstractThe aim of this study was to assess the role of magnetic resonance imaging (MRI) in the diagnosis of fetal anomalies and its correlation with antenatal Ultrasound (US) and histopathology. The study was conducted in the Department of Radiodiagnosis, Basaveshwar Teaching and General Hospital attached to Mahadevappa Rampure Medical College, Kalaburagi. It was conducted over 6 months and included pregnant women with suspected fetal anomalies on US. MR images were read independently by two radiologists and findings were confirmed with histopathology and post natal follow up. 15 patients underwent MRI for different indications all of who were referred after US. In 8/15 cases (53.34%), the US findings and MRI findings were concordant. MRI imaging provided additional information in 7/15 cases (46.66%). With advances in MRI technology and cumulative experience, MRI can be used as a valuable complementary tool to ultrasound in detecting and better evaluating fetal anomalies. The major role of fetal MRI is confirmation of abnormal sonological findings, evaluation of sonological occult fetal CNS pathologies and reassurance in equivocal US findings.
Role of vitamin D and calcium signaling in epidermal wound healing
Authors: Bikle D. D. 
Published: August 2022

Abstract
Purpose
This review will discuss the role of vitamin D and calcium signaling in the epidermal wound response with particular focus on the stem cells of the epidermis and hair follicle that contribute to the wounding response.

Methods
Selected publications relevant to the mechanisms of wound healing in general and the roles of calcium and vitamin D in wound healing in particular were reviewed.

Results
Following wounding the stem cells of the hair follicle and interfollicular epidermis are activated to proliferate and migrate to the wound where they take on an epidermal fate to re-epithelialize the wound and regenerate the epidermis. The vitamin D and calcium sensing receptors (VDR and CaSR, respectively) are expressed in the stem cells of the hair follicle and epidermis where they play a critical role in enabling the stem cells to respond to wounding. Deletion of Vdr and/or Casr from these cells delays wound healing. The VDR is regulated by co-regulators such as the Med 1 complex and other transcription factors such as Ctnnb (beta-catenin) and p63. The formation of the Cdh1/Ctnn (E-cadherin/catenin) complex jointly stimulated by vitamin D and calcium plays a critical role in the activation, migration, and re-epithelialization processes.

Conclusion
Vitamin D and calcium signaling are critical for the ability of epidermal and hair follicle stem cells to respond to wounding. Vitamin D deficiency with the accompanying decrease in calcium signaling can result in delayed and/or chronic wounds, a major cause of morbidity, loss of productivity, and medical expense.
Pre-swirl fins design for improved propulsive performances: application to fast twin-screw passenger ships
Authors: Gaggero Stefano , Martinelli Mattia 
Published: August 2022

AbstractPre-swirl fins-based energy saving devices (ESDs) have been designed to improve the propulsive performances of twin-screw ships. To this aim, a combined BEM/RANSE method for efficient self-propulsion prediction is required. The approach is included in a framework for a design by optimization, where systematic variations of the ESD geometry have been used to explore the design space and maximize the energy-saving effect of the device. Surrogate models based on Ordinary Kriging are used too, with the aim of realizing an affordable design workflow for the very preliminary design of such devices. The results show encouraging improvements that reach promising energy-savings up to 3% at the design point and satisfactory savings also in off-design functioning conditions.
Non-pharmaceutical Interventions and Social Distancing as Intersubjective Care and Collective Protection
Authors: Piroddi Corrado 
Published: August 2022

AbstractThe paper discusses non-pharmaceutical interventions (NPIs) as a collective form of protection that, in terms of health justice, benefits groups at risk, allowing them to engage in social life and activities during health crises. More specifically, the paper asserts that NPIs that realize social distancing are justifiable insofar as they are constitutive of a type of social protection that allows everyone, especially social disadvantaged agents, to access the public health sphere and other fundamental social spheres, such as the family and civil society.
The perceived quality of video consultations in geriatric outpatient care by early adopters
Authors: Spronk Romy , van der Zaag-Loonen Hester J. , Bottenberg-Wigbold Nicole , Bovee Nadine , Smits Rosalinde , van Offenbeek Marjolein , Vos Janita F. J. , Luttik Marie Louise , van Munster Barbara C. 
Published: August 2022

Abstract
Purpose
The COVID-19 pandemic caused rapid implementation and upscaling of video consulting. This study examined the perceived quality of care delivered through video consulting at a geriatric outpatient clinic, and how this related to adoption issues and barriers early adopting professionals found themselves confronted with.

Methods
We performed a qualitative study using semi-structured interviews with healthcare professionals complemented by the views of geriatric patients, family caregivers and medical secretaries. Participants from five academic centers and six teaching hospitals were included. Three researchers conducted the interviews, coded the data, and used thematic analysis.

Results
Interviews were conducted with 13 healthcare professionals, 8 patients, 7 family caregivers, and 4 medical secretaries. From these early adopters, we infer five criteria positively contributing to perceived quality of care provided by video consulting: (1) the patient has an intact cognitive function; (2) a family caregiver with digital literacy can be present; (3) doctor and patient already have an established relationship; (4) no immediate need for physical examination or intervention; and (5) the prior availability of a comprehensive and concise medical history. Overall, the uptake of video consulting in geriatric outpatient care appeared to be slow and laborious due to several implementation barriers.

Conclusion
The implementation of video consulting use among geriatricians and geriatric patients at the geriatric outpatient clinic was slow due to the absence of many facilitating factors, but video consulting might be offered as an alternative to face-to-face follow-up to suitable patients in geriatric outpatient clinics.
Understanding adolescent mental health and well-being: a qualitative study of school stakeholders’ perspectives to inform intervention development
Authors: Neill Ruth D. , Lloyd Katrina , Best Paul , Tully Mark. A. 
Published: August 2022

AbstractThere has been an increasing prevalence of mental health issues among adolescents. Early interventions in the school setting have been identified as a way to help reduce and prevent these issues. However, the input of key school stakeholders is largely neglected within the intervention development process. This study aims to address this deficit by exploring student and teacher perspectives on adolescent mental health and the barriers and facilitators to intervention development. Data were collected through six focus groups with 32 students and seven semi-structured interviews with teachers were conducted in one secondary school in Northern Ireland, alongside observations across the whole school. The data were analysed using thematic analysis. The main themes identified were Test anxiety as a detrimental factor to adolescent mental health particularly within the school setting. and the use of a multi-component intervention involving communication, education and physical activity could help reduce anxiety and improve well-being. Perceived facilitators for intervention development were co-production, pupil ownership and target age while barriers included the school’s role in mental health prevention, mixed interests of adolescents, and time constraints. Issues such as test anxiety are important factors to consider in designing a school-based intervention. A school-based intervention should be multi-dimensional to allow the programme to be tailored and sustainable for the school setting. Future research with a larger representative sample is required to obtain information on the acceptance of the intervention developed from this research.