bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of light fixed‐wing airborne time‐domain electromagnetic system for mapping the near‐surface cover layer in an alluvial plain context: A numerical study
Authors: Schamper Cyril , Sab Guillaume‐Alexandre , Rejiba Fayçal , Flipo Nicolas 
Published: November 2022

AbstractThe mapping of the vertical and lateral variations in the physical properties of the few‐meter cover layer over near‐surface aquifers is important for hydrogeological modelling, particularly for the quantification of the recharge of groundwater systems. The first ground‐based time‐domain electromagnetic survey over a small catchment (Avesnelles, France) of the watershed of Orgeval (Seine basin) was carried out to determine discontinuities in the first silt layer as well as in the Brie multilevel aquifer limestone horizon. The results highlighted the following: (1) a good sensitivity of the time‐domain electromagnetic survey to the presence of multi‐decametric resistive sand lenses, particularly in a location where they were previously identified and (2) the interest in conducting a survey at a fine sampling step but extending to the meso‐scale. To overcome the sampling issue over a watershed of several hundred square kilometres, we proposed numerically assessing the use of a prototype of low‐cost airborne transient electromagnetic systems towed by light fixed‐wing airplanes (with transmitting and receiving loops in the same plane). The present numerical analysis, in 1D for the vertical (i.e. thickness) variation and in 3D for the lateral extensions of localized sandy and resistive units, showed that a conductive few‐meter cover can be mapped even with a system flying at 50 m with, however, the need of a priori constraint on the resistivity of the first layer to estimate its thickness variation as accurately as possible. Even if it did not bring more sensitivity to the layer thickness and despite the severe difficulty of practical implementation with a decametric emission loop, the vertical co‐planar configuration potentially offered better near‐surface lateral resolution (down to ∼40 m) to delineate the sandy units (discontinuities) within the silt layer (if units are at least 50 m in size) and provided better spatial constraints compared to the classical horizontal co‐planar geometry used in the time‐domain electromagnetic. Even if not aerodynamically in the plane of the emission loop, the measurement of the Hx component with a vertical dipole emission loop (PERPxz geometry for perpendicular) improved the lateral resolution (down to ∼20 m; still with at least 50 m size sand units) and confirmed that a geometry different from the classical horizontal co‐planar configuration could be valuable.
The (Un)Controllability Principle: The Benefits of Holding Employees Accountable for Uncontrollable Factors
Authors: ZUREICH JACOB 
Published: November 2022

ABSTRACTThe controllability principle suggests that employees should not be held accountable for factors outside their control. This study develops novel theory to challenge that thinking. According to the theory, holding employees accountable for uncontrollable factors like peer performance can lead to improved decision‐making by increasing how much employees learn from those uncontrollable factors. I expect this effect to occur because goal‐focused employees only consider information that seems goal‐relevant, and uncontrollable factors only seem goal relevant when employees are held accountable for them. Results from a decision‐making experiment support the theory. In particular, paying participants based on uncontrollable factors improves their decision‐making despite providing them with weaker economic incentives. This positive effect is more pronounced when the uncontrollable factors are more informative and when individuals are more goal‐focused. These findings reveal a previously unexplored benefit of disregarding the controllability principle that can help explain why broad, uncontrollable metrics are so prevalent and successful in practice.
Missed presentations, missed opportunities: A cross‐sectional study of mental health presentation undercounting in the emergency department
Authors: Werkmeister Catherine , Cunningham Ruth , Freeland Abigail , Stanley James , Every‐Palmer Susanna , Kuehl Silke 
Published: November 2022

AbstractObjectivesThe burden of mental illness is increasing across developed countries. EDs are often used as access points by people experiencing mental health crises, with such rising demand in Australasia. Accurate data is critical to track and address this need, but research suggests that current data collection methods undercount mental health presentations to the EDs. The present study aimed to quantify and characterise ED mental health presentations that were not identified by usual clinical coding processes.MethodsFrom almost 50 000 presentations to a large regional ED over 12 months, 1988 were mental health‐related as identified via discharge diagnoses and ICD‐10 codes. For a further 384 presentations, it was ambiguous whether they were mental health‐related. For these, free‐text clinical notes were reviewed to identify mental health‐related presentation missed by clinical coding practices. Demographic information, time of presentation, recent use of secondary mental health services and disposition from ED were extracted and analysed.ResultsAn additional 91 mental health presentations were found by review of clinical notes; 4.6% (95% confidence interval 3.7–5.6) more presentations than identified via screening of discharge codes. In these ‘missed’ cases, clinicians had documented clear mental health symptoms but without coding the corresponding diagnosis. Existing clinical coding practices were less accurate for patients who were not current or recent users of mental health services, and for those who were discharged directly from ED.ConclusionsThe present study demonstrates that ED mental health presentations may be underestimated by nearly 5%, revealing greater mental health demand than current figures suggest.
Effect of vitamin D receptor activators on cardiovascular events in patients on hemodialysis—A post hoc analysis of the LANDMARK study
Authors: Yoshida Kiryu , Mizukami Takuya , Fukagawa Masafumi , Akizawa Tadao , Morohoshi Hokuto , Sambe Takehiko , Takeshima Akiko , Ito Hidetoshi , Ogata Hiroaki , Uchida Naoki 
Published: November 2022

AbstractIntroductionThe clinical benefit of vitamin D receptor activators (VDRA) in patients with well‐controlled secondary hyperparathyroidism undergoing dialysis remains unclear.MethodsThis post hoc analysis of the LANDMARK study investigates if VDRA use is associated with cardiovascular benefits. Data of 2135 patients undergoing hemodialysis who were at risk for vascular calcification were analyzed using a Cox proportional hazards model with propensity‐score matching.ResultsThe hazard ratio (HR) for VDRA use was 0.99 (95% confidence interval [CI]: 0.67–1.46; p = 0.945) for cardiovascular events and 0.89 (95% CI: 0.62–1.28; p = 0.541) for all‐cause mortality at baseline. Among patients who always used VDRA, the HR was 1.12 (95% CI: 0.67–1.89; p = 0.666) for cardiovascular events and 1.11 (95% CI: 0.67–1.85; p = 0.688) for all‐cause mortality compared to those who never used VDRA.ConclusionThe use of VDRA does not reduce the risks of cardiovascular events or all‐cause mortality in patients on dialysis with well‐controlled secondary hyperparathyroidism.
Proteome changes in autosomal recessive primary microcephaly
Authors: Zaqout Sami , Mannaa Atef , Klein Oliver , Krajewski Angelika , Klose Joachim , Luise‐Becker Lena , Elsabagh Ahmed , Ferih Khaled , Kraemer Nadine , Ravindran Ethiraj , Makridis Konstantin , Kaindl Angela M. 
Published: November 2022

AbstractBackground/aim: Autosomal recessive primary microcephaly (MCPH) is a rare and genetically heterogeneous group of disorders characterized by intellectual disability and microcephaly at birth, classically without further organ involvement. MCPH3 is caused by biallelic variants in the cyclin‐dependent kinase 5 regulatory subunit‐associated protein 2 gene CDK5RAP2. In the corresponding Cdk5rap2 mutant or Hertwig's anemia mouse model, congenital microcephaly as well as defects in the hematopoietic system, germ cells and eyes have been reported. The reduction in brain volume, particularly affecting gray matter, has been attributed mainly to disturbances in the proliferation and survival of early neuronal progenitors. In addition, defects in dendritic development and synaptogenesis exist that affect the excitation‐inhibition balance. Here, we studied proteomic changes in cerebral cortices of Cdk5rap2 mutant mice.Material and methods: We used large‐gel two‐dimensional gel (2‐DE) electrophoresis to separate cortical proteins. 2‐DE gels were visualized by a trained observer on a light box. Spot changes were considered with respect to presence/absence, quantitative variation and altered mobility.Result: We identified a reduction in more than 30 proteins that play a role in processes such as cell cytoskeleton dynamics, cell cycle progression, ciliary functions and apoptosis. These proteome changes in the MCPH3 model can be associated with various functional and morphological alterations of the developing brain.Conclusion: Our results shed light on potential protein candidates for the disease‐associated phenotype reported in MCPH3.
Two year follow‐up and comparison of pelvic floor muscle electromyography after first vaginal delivery with and without episiotomy and its correlation with urinary incontinence: A prospective cohort study
Authors: Min Li , Xudong Dong , Qiubo Lyu , Pingping Li , Yuhan Lyu , Guifang Zhang , Tianzi Gai , Qing Feng , Chunxue Yang , Yaxin Liang 
Published: November 2022

AbstractIntroductionFew prospective studies have revealed the long‐term neuromuscular alterations of pelvic floor after vaginal delivery. The aim of this study was to evaluate the impact of episiotomy on the electrical activity of pelvic floor muscle 2 years following vaginal delivery, and explore the relation between surface electromyography (sEMG) amplitudes and urinary incontinence.Material and methodsA total of 427 primiparous women with full‐term singleton vaginal delivery were included in the cohort and 362 with no further births within the 2 year follow‐up completed observations. Of these, 200 underwent episiotomy and 162 underwent nonepisiotomy. Clinical demographic characteristics, vaginal EMG variables and urinary incontinence‐specific questionnaire scores were collected at 6 weeks, 6, 12 and 24 months after childbirth, respectively. Primary outcomes were the comparison of sEMG values between the episiotomy and nonepisiotomy groups throughout 2 years. Secondary outcomes were the correlation between sEMG of both groups and the incidence and severity of urinary incontinence. Spearman's correlation analysis, Kruskal‐Wallis test and ANOVA with Bonferroni correction were used to analyze the variables.ResultsAmplitude of maximal fast and endurance contractions on sEMG in the episiotomy group was significantly lower than the nonepisiotomy counterpart. Such difference of sEMG persisted for a long period after birth: endurance contraction, 33.12 ± 8.92 vs 35.085 ± 9.98, p < 0.01 at 24 months, and fast contraction, 36.53 ± 8.87 vs 39.05 ± 9.98, p = 0.01 at 12‐month. Although there was no significant difference in incidence and severity of urinary incontinence between both groups, a negative correlation existed between EMG values of muscle contraction and urinary incontinence symptoms throughout.ConclusionsPrimiparous women delivered with episiotomy demonstrated lower contractile sEMG activity of pelvic floor muscle in the long term. The lower sEMG values of fast contraction were associated with urinary incontinence symptoms.
Laparoscopic distal pancreatectomy for hemosuccus pancreaticus due to an intraductal papillary mucinous neoplasm
Authors: Ide Takao , Uchikawa Kazuya , Noshiro Hirokazu 
Published: November 2022

AbstractHemosuccus pancreaticus (HP) is a condition that is defined as gastrointestinal hemorrhage which occurs through the pancreatic duct. We present the rare case of a 75‐year‐old woman who developed HP caused by intraductal papillary mucinous neoplasm (IPMN). She had been followed for sarcoidosis, splenic artery aneurysm and pancreatic cyst. The patient presented to the emergency room of our hospital with epigastric pain and bloody discharge. Computed tomography revealed hemorrhage from a splenic artery aneurysm in a cystic lesion of the pancreas. On angiography, extravasation from the splenic artery was observed. Thus, we performed coil embolization. After interventional radiography (IVR), magnetic resonance imaging and endoscopic retrograde pancreatography showed a branch duct IPMN. Based on these findings, elective laparoscopic distal pancreatectomy was performed. The histopathological diagnosis was IPMN with HP caused by rupture of a splenic artery aneurysm. For such complicated cases, minimally invasive surgery is applicable after successful hemostasis by IVR.
Child well‐being in the context of family harmony: Parental marital relationship as mediator and parent–child attachment style as moderator
Authors: Mohd‐Zaharim Norzarina , Hashim Intan H. M. 
Published: November 2022

AbstractExtant research in Western countries have indicated that children's well‐being may be influenced by children's own resilience, parent–child attachment, and parental marital relationship. Yet, there is very little research in Malaysia on how these factors may influence well‐being among children in middle childhood. The aim of this study, therefore, was to explore the relationships among children's self‐efficacy—a resilience factor—and well‐being, parental marital relationship, and parent–child attachment style. The study used a quantitative, cross‐sectional survey method. Participants were 955 Malay‐Malaysian children aged 11 years from intact families. They responded to a questionnaire on demographic background, self‐efficacy, well‐being, parental harmony and conflict, and parent–child attachment style. Moderated mediation analysis indicated that (i) parental harmony was a significant mediator for the relationship between children's self‐efficacy and well‐being; (ii) parental conflict was not a significant mediator for the relationship between children's self‐efficacy and well‐being; and (iii) parent–child attachment style was a significant moderator for the relationship between children's self‐efficacy and well‐being. These findings are discussed within the frameworks of optimal child development and family relationship. These findings may also inform policies such as Malaysia's Sustainable Development Goal 3 (SDG 3) and National Family Policy.
Mesh Draping: Parametrization‐Free Neural Mesh Transfer
Authors: Hertz A. , Perel O. , Giryes R. , Sorkine‐Hornung O. , Cohen‐Or D. 
Published: November 2022

AbstractDespite recent advances in geometric modelling, 3D mesh modelling still involves a considerable amount of manual labour by experts. In this paper, we introduce Mesh Draping: a neural method for transferring existing mesh structure from one shape to another. The method drapes the source mesh over the target geometry and at the same time seeks to preserve the carefully designed characteristics of the source mesh. At its core, our method deforms the source mesh using progressive positional encoding (PE). We show that by leveraging gradually increasing frequencies to guide the neural optimization, we are able to achieve stable and high‐quality mesh transfer. Our approach is simple and requires little user guidance, compared to contemporary surface mapping techniques which rely on parametrization or careful manual tuning. Most importantly, Mesh Draping is a parameterization‐free method, and thus applicable to a variety of target shape representations, including point clouds, polygon soups and non‐manifold meshes. We demonstrate that the transferred meshing remains faithful to the source mesh design characteristics, and at the same time fits the target geometry well.
Clinical and echocardiographic evolution of patients with arrhythmogenic cardiomyopathy before heart transplantation
Authors: Rimac Goran , Poulakos Nickolas , Beaulieu‐Shearer Alexander , Dupuis Céline , Beaudoin Jonathan , Lemay Sylvain , Lalancette Jean‐Simon , Trahan Sylvain , Racine Hugo‐Pierre , Steinberg Christian , Sénéchal Mario , Turgeon Pierre Yves 
Published: November 2022

AbstractBackgroundArrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy characterized by fibrofatty myocardial replacement, and accurate diagnosis can be challenging. The clinical course of patients expressing a severe phenotype of the disease needing heart transplantation (HTx) is not well described in the literature. Therefore, this study aims to describe the clinical and echocardiographic evolution of patients with ACM necessitating HTx.MethodsWe retrospectively studied all patients who underwent HTx in our institution between 1998 and 2019 with a definite diagnosis of ACM according to the explanted heart examination.ResultsTen patients with confirmed ACM underwent HTx. Only four of them had a diagnosis of ACM before HTx. These patients were 28 ± 15 years old at the time of their first symptoms. Patients received a diagnosis of heart failure (HF) after 5.9 ± 8.7 years of symptom evolution. The mean age at transplantation was 40 ± 17 years old. All the patients experienced ventricular tachycardia (VT) at least once before their HTx and 50% were resuscitated after sudden death. The mean left ventricular ejection at diagnosis and before transplantation was similar (32% ± 21% vs. 35.0% ± 19.3%, p = NS). Right ventricular dysfunction was present in all patients at the time of transplantation.ConclusionPatients with ACM necessitating HTx show a high burden of ventricular arrhythmias and frequently present a biventricular involvement phenotype, making early diagnosis challenging. HF symptoms are the most frequent reason leading to the decision to transplant.
The Potential of Industrial Agglomeration to Promote Pharmaceutical Innovation: Analysis of China's “Medicine Valley” Construction Upsurge
Authors: Fan Jianting , Zhao Fusen , Zhao Yuhao 
Published: November 2022

AbstractThis paper reports the innovation effect of pharmaceutical industry agglomeration from the perspective of patterns of agglomeration and innovation, by using registration application data for innovative and generic drugs as indicators of pharmaceutical innovation. First, the distribution of the pharmaceutical industry in China is characterized by high agglomeration and low innovation. Second, no significant influence is exerted by regional industrial and development zone agglomeration on the development of innovative drugs in different regions; the effect of the promotion of generic drugs is reflected mainly in the location entropy index. Third, the existence of a crowding effect weakens the effect of the promotion of agglomeration on pharmaceutical innovation and the adverse impact on innovative drugs is significantly greater than the effect on generic drugs. In further research, we explored the bias effect of agglomeration in development zones and the synergistic effects of different agglomeration models. It is difficult to improve the quality of independent innovation by spatial agglomeration. Government‐led development zones play a rather limited role in pharmaceutical innovation.
The Market Reaction to Cross‐border Listings: Evidence from AH Listed Firms
Authors: Zhang John Fan 
Published: November 2022

AbstractThis study examines the abnormal returns of Chinese firms dual‐listed on the Chinese mainland (A‐share) and Hong Kong SAR (H‐share) stock markets. The results show that abnormal returns are more significant for the existing H‐share firms cross‐listing back as (H‐to‐A cross‐listings) than for those that are the other way around (A‐to‐H cross‐listings). Further, the A‐share market is more responsive to announcements, whereas the H‐share market is more responsive to actual listings. The analysis of the underlying mechanisms reveals that the abnormal returns of A‐to‐H cross‐listings are associated with improved information. In contrast, the abnormal returns of H‐to‐A cross‐listings are related to an increase in valuation. Significant abnormal returns for H‐to‐A cross‐listings are driven mainly by reduced systematic risks and are more pronounced in the post‐1997 period. Overall, these results suggest that investors generally respond positively to AH dual listings of Chinese firms.
Car accident as a trigger for reverse takotsubo‐like cardiomyopathy with paraganglioma: Case report and literature review
Authors: Dai Liya , Zhou Ning , Zhou Kechun , Zhang Fangbiao , Chen Fanghon 
Published: November 2022

AbstractParaganglioma (PGL), which may cause acute Takotsubo‐like cardiomyopathy (TLC), is a rare neuroendocrine neoplasm derived from various body sites. TLC has been associated with excessive catecholamine secretion and shares the same cardiac presentation with Takotsubo cardiomyopathy (TTC). We present the case of a 58‐year‐old male who arrived at the hospital after a car accident, reporting symptoms of chest tightness, shortness of breath, and abdominal pain after a car accident. The patient was found to have elevated troponin and severely depressed left ventricular function. Echocardiography depicted a normal contracting apex with the rest of the left ventricle being hypokinetic. Coronary computed tomography (CT) angiogram revealed mild coronary artery disease. Abdominal CT further revealed a mass on the left side of the epigastric aorta, confirmed by autopsy as a PGL.
The outcome of peripartum cardiomyopathy patients‐single center experience
Authors: Demir Emre , Ceylan Naim , Bayraktaroğlu Selen , Çinkooğlu Akın , Candemir Aytaç , Candemir Yeşim B. , Güneş Mustafa Talha , Yeniyol Şevket , Yılmaz Elfin B. , Zoghi Mehdi , Akıllı Azem , Gürgün Cemil , Nalbantgil Sanem 
Published: November 2022

AbstractObjectivePeripartum cardiomyopathy (PPCM) diagnosis made by excluding identifiable causes of heart failure (HF) and occurs end of the pregnancy or during the postpartum period of five months. It presents a clinical HF spectrum with left ventricular systolic dysfunction.BackgroundThe purpose of this study is to retrospectively evaluate the clinical characteristics, cardiac magnetic resonance (CMR) imaging features, and end‐points consisting of left ventricle recovery, left ventricular assist device implantation, heart transplantation, and all‐cause mortality.MethodOutpatient HF records between 2008 to 2021 were screened. Thirty‐seven patients were defined as PPCM. Twenty‐five patients had CMR evaluation at the time of diagnosis, and six patients were re‐evaluated with CMR.ResultsThe mean age was 30.5 ± 5.6 years, and the mean LVEF was 28.2% ± 6.7%. In 13(35.7%) patients, LVEF recovered during the follow‐up course. The median recovery time was 281(IQR [78–358]) days. LVEF on CMR was 35.3 ± 10.5, and three patients exhibited late gadolinium enhancement(LGE) patterns. Sub‐endocardial and mid‐wall uptake pattern types were detected. 18(75%) patients met the Petersen left ventricle non‐compaction cardiomyopathy(LVNC) criteria. Patients with NC/C ratio lower than 2.3 had lower LVEDVi and LVESVi (124.9 ± 35.4, 86.4 ± 7.5, p = .003; 86.8 ± 34.6, 52.6 ± 7.6, p = .006), respectively. The median follow‐up time was 2129 (IQR [911–2634]) days. The primary endpoint‐free 1‐year survival was 88.9% (event rate 11.1%), and 5‐year survival was 75.7% (event rate 24.3%).ConclusionIn a retrospective cohort of PPCM patients, 35.7% of patients’ LVEF recovered, and the primary end‐point of free‐5‐year survival was 75%. Twenty‐five patients were assessed with CMR; three of four met the Petersen CMR‐derived LVNC at initial evaluation.