bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outpatient administration of naxitamab in combination with granulocyte‐macrophage colony‐stimulating factor in patients with refractory and/or relapsed high‐risk neuroblastoma: Management of adverse events
Authors: Mora Jaume , Chan Godfrey C. , Morgenstern Daniel A. , Nysom Karsten , Bear Melissa K. , Tornøe Karen , Kushner Brian H. 
Published: May 2022

AbstractBackgroundNaxitamab is a humanized GD2‐binding monoclonal antibody that received accelerated approval from the U.S. Food and Drug Administration for refractory or relapsed high‐risk neuroblastoma limited to bone or bone marrow. Trial 201 (NCT03363373) is an ongoing global clinical trial to evaluate the efficacy and safety of naxitamab in combination with granulocyte‐macrophage colony‐stimulating factor in this population.AimsHere, we review the safety profile and adverse event (AE) management associated with naxitamab administration in a pediatric population, based on Trial 201 protocol guidelines and clinical trial experience.Methods and ResultsAt least 50% of patients experienced pain, hypotension, bronchospasm, cough, vomiting, diarrhea, nausea, and tachycardia, with the following reported at grade ≥3 AEs for at least 10% of patients: pain, hypotension, urticaria, and bronchospasm. These AEs were generally manageable in the outpatient setting using premedications, supportive therapies, and appropriate monitoring post‐infusion. Algorithms were established for infusion‐related AEs, including hypotension and bronchospasm, to provide guidance to investigators for early recognition and timely intervention, including medication and infusion rate modification or interruption, or treatment discontinuation, based on AE severity. Educating patients and caregivers on what to expect regarding premedication at home, experience during the infusion cycle, and post‐infusion monitoring helps optimize naxitamab treatment and supportive therapies and may reduce treatment burden.ConclusionThis article highlights the protocol‐based recommendations for the management of acute AEs associated with outpatient naxitamab treatment in Trial 201. The authors recommend close monitoring and timely implementation of measures to ensure that patients can remain on treatment and obtain maximum clinical benefit from naxitamab therapy.
Impact analysis of government microblog participation in public management based on association analysis and edge computing
Authors: Hu Shiwen , Yao Ming 
Published: May 2022

AbstractThe government affairs microblogging platform helps the government to interact effectively with the public, thereby guiding the public to combine the demands of the real society with the expressions in the virtual community and achieve orderly public participation. This paper adopts a combination of association analysis and edge computing to analyze the impact of government microblog participation in public management. First, this paper designs a government microblog evaluation framework based on edge computing technology. Second, in order to deeply understand the relationship between highly active government microblogs and public trust, this paper evaluates the influence of government microblogs by correlating indicators such as forwarding volume and number of comments. The results show that the evaluation results obtained by this model have little difference with the expert evaluation results. The above scheme helps to deepen the theoretical study of media credibility in the context of social media.
A new applicable and multilayer design of nanoscale adder–subtractor using quantum‐dots
Authors: Gao Yuan , Mohammed Bayan Omar 
Published: May 2022

AbstractQuantum‐dot cellular automata (QCA) is a technique that can substitute silicon transistors. Besides, the computational architecture and systems are focused on nanoscale QCA in response to industry demands for energy‐efficient and high‐performance computing systems. Because of the importance of adder/subtractor designs in logical circuits, a novel QCA‐based adder/subtractor design is suggested in this study. A full adder is developed first, followed by a full subtractor. These QCA‐based adder/subtractor designs are simple, ultra‐efficient, constructive, and have easy input and output access. To create the required output, these circuits make use of quantum technology's intrinsic features. The QCADesigner program is used to assess the simulation findings of the recommended designs. Additionally, these designs are investigated in terms of complexity, clocking, cells, and latency. It shows that the recommended design is more efficient than standard designs regarding the area, cell count, and cost. These circuits are among the circuits in which easy access to inputs and outputs is provided, and their connection to other circuits makes them more practical. In addition to the above, the low number of cells, high speed, and easy implementation are among the innovations of the presented circuits.
Implant stability of narrow diameter implants in hyperglycemic patients—A 3‐month case–control study
Authors: Diehl Daniel , Winkler Marianna , Bilhan Hakan , Friedmann Anton 
Published: May 2022

AbstractObjectivesThe aim of this prospective case–control study was to compare the development of implant stability quotients of narrow diameter implants in patients with type 2 diabetes mellitus (T2DM) and healthy individuals within the first 3 months after implant insertion.MethodsSixteen patients with T2DM (HbA1C > 6.5%) as test group and 16 nondiabetic patients (HbA1C < 5.9%) as the control group were evaluated. All patients received narrow‐diameter tissue level implants in an edentulous area posterior to the canine. The implant stability was measured by means of resonance frequency analysis after 3 days, 7 days, 4 weeks, and 3 months postplacement. Statistical analysis of intergroup differences and correlation to HbA1c values and treated jaw was performed in PRISM 8.ResultsThe means for implant stability quotients showed a significant increase between Day 3 and 3‐month assessment in both groups. No significant differences between study groups and no correlation of implant stability to HbA1c were found.ConclusionThe present study shows encouraging clinical outcomes for narrow‐diameter implants inserted in the posterior zone in patients with uncontrolled T2DM.
Experimentelle Untersuchungen von Mauerwerk aus Ziegelsplittbeton‐Hohlblocksteinen der Nachkriegszeit
Authors: Hammerschmidt Verena , Pommer Georg , Kolbitsch Andreas 
Published: May 2022

AbstractDie Tragfähigkeitsbewertung von Bestandsmauerwerk aus der Nachkriegszeit stellt besonders in Gebieten, wo aufgrund der Vielzahl an zerstörten Gebäuden rasch Wohnraum geschaffen werden musste, ein bedeutendes Thema dar. Aufgrund der fortschreitenden Lebensdauer der Gebäude und der damit verbundenen baulichen Maßnahmen sowie der innerstädtischen Wohnraumverdichtung ist das Mauerwerk hinsichtlich seiner Tragfähigkeit nachzuweisen. Unter anderem wurden im Zeitraum von 1945 bis 1965 speziell im Wohnbau Hohlblocksteine aus Ziegelsplittbeton, sog. Vibrosteine, als tragendes Mauerwerk verbaut. Da herkömmliche zerstörungsfreie und zerstörungsarme Prüfmethoden bei Hohlblocksteinen nur bedingt zur Festigkeitsbestimmung herangezogen werden können, ist die Kenntnis über die charakteristischen Materialeigenschaften von besonderer Relevanz. Im Rahmen der vorliegenden Arbeit wurden am Bestand Vibrosteine entnommen und experimentell Festigkeits‐ sowie Verformungseigenschaften an Mauerstein und Mauerwerk bestimmt. Die durchgeführten Untersuchungen sollen Aufschluss über das charakteristische Materialverhalten der Hohlblocksteine aus Ziegelsplittbeton der Nachkriegszeit geben und Grundlagen für zukünftige Tragfähigkeitsbewertungen des Gebäudebestands bieten.
Leistungsfähigkeit und Einsatzmöglichkeiten zementstabilisierter Lehmsteine
Authors: Fischer Daniel , Kotan Engin , Dehn Frank 
Published: May 2022

AbstractAn der Schnittstelle zwischen herkömmlichen Lehm‐ und modernen Massivbaustoffen haben sich in jüngerer Vergangenheit zementstabilisierte Lehmsteine als vielversprechende Alternative für den Mauerwerksbau entwickelt. Sie bergen das Potenzial, die ökologischen und ökonomischen Vorteile des Lehmbaus zu nutzen, ohne die übliche Empfindlichkeit gegenüber Feuchtigkeit aufzuweisen. Die gültigen Normen und Regelungen erlauben jedoch keine ingenieurmäßige Bemessung eines Mauerwerks aus zementstabilisierten Lehmsteinen. Zur Untersuchung des Potenzials zementstabilisierter Lehmsteine befasst sich der vorliegende Aufsatz daher eingehend mit den verschiedenen Einflussfaktoren der Herstellung, der Weiterverarbeitung zum Mauerwerk und der Witterung. Die Erkenntnisse und Angaben aus der Fachliteratur und der Anwendung in Ostafrika werden hierbei durch Druckfestigkeitsprüfungen an zementstabilisierten Lehmsteinen und Mauerwerksprüfkörpern verifiziert und ergänzt. Dieser ganzheitliche Ansatz ermöglicht eine Bewertung der Druckfestigkeit zementstabilisierter Lehmsteine mit einer anschließenden Bemessung in Anlehnung an das vereinfachte Verfahren nach Anhang A der DIN EN 1996‐3. Darauf aufbauend wird ein Ausblick auf künftige Einsatzmöglichkeiten und Anwendungsgrenzen eines Mauerwerks aus zementstabilisierten Lehmsteinen gegeben.
Preparation of MgAl layered double oxides and its adsorption kinetics for ciprofloxacin hydrochloride in water
Authors: Gao Ruqin , Huang Yingrui , He Jianling , Shi Wenjie , Huang Shiyu , Pan Lu , Pan Zhiyong , Li Guoting 
Published: May 2022

AbstractMagnesium aluminum carbonate hydrotalcites (MgAl‐LDHs) were prepared by a coprecipitation method using magnesium nitrate and aluminum nitrate as raw materials, and then calcined at high temperature to obtain hydrotalcite‐like MgAl layered double oxides (MgAl‐LDOs). With ciprofloxacin hydrochloride as the target pollutant, and the adsorption kinetics of ciprofloxacin hydrochloride by MgAl‐LDOs were assessed. The results show that: MgAl‐LDHs and MgAl‐LDOs are both mesoporous adsorbent materials. After MgAl‐LDHs were calcined at 400°C, their layered structure began to collapse partially. At the same time, their specific surface area, pore volume, and average pore diameter increased from 123.593 m2/g, 0.666 cm3/g, and 21.54 nm to 185.908 m2/g, 1.414 cm3/g, and 30.42 nm, respectively. The ability of MgAl‐LDOs to remove ciprofloxacin hydrochloride in water is much greater than that of MgAl‐LDHs. The research has shown that when the concentration of ciprofloxacin hydrochloride solution is 10 mg/L, at a pH of 5, and a temperature of 25°C, the equilibrium adsorption capacity can reach 22.69 mg/g in 420 min. The results of the quasi‐first‐order kinetic model and the quasi‐second‐order kinetic model show that the parameter R2 of MgAl‐LDOs adsorption of ciprofloxacin hydrochloride exceeds 0.94. The fitting parameters qe = 22.96 mg/g (10 mg/L) and qe = 107.02 mg/g (50 mg/L) in the quasi‐first‐order kinetic model, and the fitting parameters qe = 25.02 mg/g (10 mg/L) and qe = 112.72 mg/g (50 mg/L) in the quasi‐second‐order kinetic model are practically consistent with the measured equilibrium adsorption capacity.
Analytical modeling of distributed network functions virtualization architectures and the impact of the distribution on the packet sojourn time
Authors: Ilievski Gjorgji , Latkoski Pero 
Published: May 2022

AbstractDistribution of network functions virtualization (NFV) environment on multiple locations and datacenters is a hot topic in research and engineering communities. In this article, we are making analytical models to calculate the network packet sojourn time in three different scenarios: classical NFV environment where all NFV elements are on the same location, distributed architecture of the data plane with centralized management and orchestration (MANO) environment, and distributed environment where every location has its own data plane and MANO elements. The analytical models are tested and discussed through Matlab based simulations. Through the simulation results, we discuss the impact of changes of different parameters on the packet sojourn time, and we compare the architectures in order to see how they can be fitted in practical services provided in an NFV environment.
Backlash
Authors: Sosa Joseph Jay 
Published: May 2022

AbstractFeminist anthropology offers conceptual and methodological clarity to the study of backlash, a phenomenon made salient once more by the global conservative turn of the 2010s. As contemporary crises of social reproduction have, once again, focused majoritarian angst and anger on women, queer people, immigrants, and people of color, scholars have returned (again) to discuss backlash. Critically, feminist anthropology can move past media narratives of backlash, which often emphasize the emotional habits of backlash perpetrators, to understand how backlash operates as a specific mode of power through the experiences of its targets. This keyword entry joins recent retheorizations in conceiving backlash not as a reactive event but rather as an elaboration of the ongoing logics of structural oppression. Critically examining media and scholarly analyses of Brazilian President Jair Bolsonaro's election and rise of the extreme right in Brazil as its case study, this entry examines how fieldwork‐based approaches offer expanded theoretical purchase on the backlash concept.
A hybrid volume of fluid and level set interface capturing scheme with quartic surface representation for unstructured meshes
Authors: Xiong Yunong , Xiao Feng , Xie Bin 
Published: May 2022

AbstractIn this article, we developed a hybrid volume of fluid (VOF) and level set interface capturing scheme with quartic surface representation for unstructured meshes. The so‐called tangent of hyperbola interface capturing‐scaling scheme with quartic surface representation (THINC‐scaling/QSR) preserves the merits of the mass/volume conservativeness from the VOF scheme along with the geometric faithfulness from the level set scheme. Compared with linear/quadratic surface representation used in many other interface capturing schemes, the fluid interface is defined more precisely as a quartic polynomial surface of the THINC function which synchronize the interface between the VOF and level set functions in a straightforward solution procedure. We update the VOF function using a finite volume formulation. The level set function is first locally updated via a semi‐Lagrangian method for interface cells and then reinitialized within each time step. Two‐dimensional algorithm has been developed and verified by some benchmark tests on unstructured meshes. Convincing evidence suggests that the present scheme, with quartic surface representation, can provide high‐fidelity solution with more pronounced sub‐grid interface capturing capability than other most advanced methods.
A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematurity
Authors: Klein Luisa , Van Steenwinckel Juliette , Fleiss Bobbi , Scheuer Till , Bührer Christoph , Faivre Valerie , Lemoine Sophie , Blugeon Corinne , Schwendimann Leslie , Csaba Zsolt , Bokobza Cindy , Vousden Dulcie A. , Lerch Jason P. , Vernon Anthony C. , Gressens Pierre , Schmitz Thomas 
Published: May 2022

AbstractPreterm infants often show pathologies of the cerebellum, which are associated with impaired motor performance, lower IQ and poor language skills at school ages. Using a mouse model of inflammation‐induced encephalopathy of prematurity driven by systemic administration of pro‐inflammatory IL‐1β, we sought to uncover causes of cerebellar damage. In this model, IL‐1β is administered between postnatal day (P) 1 to day 5, a timing equivalent to the last trimester for brain development in humans. Structural MRI analysis revealed that systemic IL‐1β treatment induced specific reductions in gray and white matter volumes of the mouse cerebellar lobules I and II (5% false discovery rate [FDR]) from P15 onwards. Preceding these MRI‐detectable cerebellar volume changes, we observed damage to oligodendroglia, with reduced proliferation of OLIG2+ cells at P10 and reduced levels of the myelin proteins myelin basic protein (MBP) and myelin‐associated glycoprotein (MAG) at P10 and P15. Increased density of IBA1+ cerebellar microglia were observed both at P5 and P45, with evidence for increased microglial proliferation at P5 and P10. Comparison of the transcriptome of microglia isolated from P5 cerebellums and cerebrums revealed significant enrichment of pro‐inflammatory markers in microglia from both regions, but cerebellar microglia displayed a unique type I interferon signaling dysregulation. Collectively, these data suggest that perinatal inflammation driven by systemic IL‐1β leads to specific cerebellar volume deficits, which likely reflect oligodendrocyte pathology downstream of microglial activation. Further studies are now required to confirm the potential of protective strategies aimed at preventing sustained type I interferon signaling driven by cerebellar microglia as an important therapeutic target.
Additional parameters to improve the prognostic value of the 8th edition of the UICC classification for human papillomavirus‐related oropharyngeal tumors
Authors: Straetmans Jos M. J. A. A. , Stuut Marijn , Lacko Martin , Hoebers Frank , Speel Ernst‐Jan M. , Kremer Bernd 
Published: May 2022

AbstractBackgroundThe prognostic reliability of the UICC's TNM classification (8th edition) for human papillomavirus (HPV)‐positive tonsillar squamous cell carcinomas (TSCCs) compared to the 7th edition was explored, and its improvement by using additional anatomical and nonanatomical parameters.MethodsOne hundred and ten HPV‐positive and 225 HPV‐negative TSCCs were retrospectively analyzed. Survival was correlated with patient and tumor characteristics (7th and 8th edition UICC TNM classification).ResultsIn HPV‐positive TSCCs, the 8th edition UICC's TNM classification correlated better with prognosis than the 7th edition. Also, smoking status was a stronger prognosticator of survival than UICC staging. Non‐ or former smokers had a 5‐year overall survival of 95.1% regardless of tumor stage. Furthermore, age (>65 years), cN3, and M1 classification were significant prognostic factors.ConclusionThe prognostic value of the 8th edition UICC's TNM classification improved significantly when compared to the 7th edition. Nonetheless, further improvement is possible by adding nonanatomical factors (smoking, age >65 year) and separating N0‐N2 from N3.
The HR ecosystem framework: Examining strategic HRM tensions in knowledge‐intensive organizations with boundary‐crossing professionals
Authors: Donnelly Rory , Hughes Emma 
Published: May 2022

AbstractIn this article, we use Snell & Morris' (2021) new HR ecosystem framework to empirically examine strategic fit and alignment tensions for knowledge‐intensive organizations and professional knowledge workers. Rich data were collected through in‐depth interviews with 75 members of faculty engaged in knowledge‐intensive work for Business and Management Schools (B&M), and the analysis of strategy documents. The application of the framework enables us to contribute to dynamic capabilities theory and SHRM in four ways. Firstly, drawing on the findings, we propose an adapted HR Ecosystem framework for analyzing knowledge‐intensive organizations, which incorporates tensions across the four subsystems of an HR ecosystem (strategy, capabilities, composition, and cultures). These tensions are shaped by interactions within and between levels (meso, macro and micro) and ecosystems. Secondly, our findings underscore the need for knowledge‐intensive organizations to engage with a plurality of collaborative and competing internal and external stakeholder interests, including those of knowledge workers who constitute key organizational stakeholders. Thirdly, our analysis shows how the views and behaviors of internal organizational stakeholders are affected by ecosystem dynamics within and beyond the physical boundaries of an organization. Fourthly, we reveal how conflicting organizational cultures connect with other HR ecosystem subsystems to constrain collegialism and cohesion. By evidencing how knowledge‐intensive organizations are in a constant flux of alignment and misalignment, the article demonstrates the value of the HR ecosystem framework in examining and informing SHRM in organizations in other industries.
Fertility and banking development: New panel evidence
Authors: Kim Dong‐Hyeon , Chen Ting‐Cih , Lin Shu‐Chin 
Published: May 2022

AbstractFertility plays a crucial role in the process of economic development. Understanding its determinants is pivotal. While most studies emphasize real factors such as industrialization and education, they usually, with a few exceptions, overlook the financial sector channel of impact. To close the gap, the paper investigates the effect of banking development on fertility. Using panel time‐series techniques to a panel of developed and developing countries, it finds that fertility rises with banking development but decreases with banking volatility. It also finds asymmetric responses of fertility to changes in banking development. Households tend to have more children when the banking sector is expanding but do not have less children when the banking sector is declining. The evidence holds for both bank credit to households and to firms. In addition, as additional sources of funds and investment opportunities, development in securities markets is found to raise fertility. Asymmetry is also detected with a larger fertility effect during market booms than busts.
Melanoma segmentation: A framework of improved DenseNet77 and UNET convolutional neural network
Authors: Nawaz Marriam , Nazir Tahira , Masood Momina , Ali Farooq , Khan Muhammad Attique , Tariq Usman , Sahar Naveera , Damaševičius Robertas 
Published: May 2022

AbstractMelanoma is the most fatal type of skin cancer which can cause the death of victims at the advanced stage. Extensive work has been presented by the researcher on computer vision for skin lesion localization. However, correct and effective melanoma segmentation is still a tough job because of the extensive variations found in the shape, color, and sizes of skin moles. Moreover, the presence of light and brightness variations further complicates the segmentation task. We have presented improved deep learning (DL)‐based approach, namely, the DenseNet77‐based UNET model. More clearly, we have introduced the DenseNet77 network at the encoder unit of the UNET approach to computing the more representative set of image features. The calculated keypoints are later segmented by the decoder of the UNET model. We have used two standard datasets, namely, the ISIC‐2017 and ISIC‐2018 to evaluate the performance of the proposed approach and acquired the segmentation accuracies of 99.21% and 99.51% for the ISIC‐2017 and ISIC‐2018 datasets, respectively. We have confirmed through both the quantitative and qualitative results that the proposed improved UNET approach is robust to skin lesions segmentation and can accurately recognize the moles of varying colors and sizes.