bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with pharmacological treatment in children with Attention-Deficit/Hyperactivity Disorders: retrospective study of a series of 77 cases in a single third-level reference center in Apulia Region
Authors: Amendola Simone , Fanizza Isabella , Scoditti Sara , De Rinaldis Marta , TRABACCA ANTONIO 
Published: July 2022

Abstract
Background: The present study analyzed data of children and adolescents with a diagnosis of attention-deficit/hyperactivity disorder (ADHD) who referred to the ADHD reference center Scientific Institute IRCCS E. Medea (Brindisi, Italy) for ADHD pharmacotherapy initiation and monitoring overtime. The main aim of the study was to examine differences between patients according to pharmacological treatment status, i.e., treatment continuation vs discontinuation.Methods: Seventy-seven children and adolescents (mean age at pharmacotherapy initiation= 9.5, standard deviation= 2.6) with ADHD received drugs treatment for ADHD at the reference center between January, 2013 and May, 2022. Demographic and clinical data were obtained from the Italian Registry for ADHD and medical records. Child Behavior Checklist (CBCL) available data were used.Results: Pharmacological treatment status was examined for patients (n= 63) with at least 12 months of follow-up after the first pharmacological administration for ADHD. After starting pharmacotherapy treatment, 49 (77.8%) patients were still on treatment whereas 14 (22.2%) discontinued it. No between group difference was observed on demographic and clinical data except for quotient of intelligence/intellectual disability and rule-breaking behavior (n= 40). Conclusions: The findings of this study highlighted the need of periodical assessment monitoring difficulties with (or reasons for poor) treatment compliance in order to provide individualized care, and were discussed according to recent scientific evidence.
NRAP: Nearest reliable anchors-based wireless positioning for irregular multi-hop networks
Authors: Hu Xiayun , WANG Mingyue , YAN Jiajia , DONG Hai 
Published: July 2022

Abstract
The position of nodes is the critical foundation for information transfer between "person to things" and "things to things" at any time and from any location in wireless multi-hop networks. The hop-based wireless positioning technology has received widespread attention because it does not requiring additional ranging devices. However, most existing hop-based positioning algorithms ignore the network topology irregularities issues, which are frequently observed in multi-hop networks and may lead to poor positioning performance. In this paper, we present a novel wireless positioning algorithm, named NRAP, for irregular networks based on the nearest reliable anchors to mitigate the impact of topology irregularities. Specifically, a more accurate per-hop distance estimation model is firstly adopted. Then, NRAP divides the entire network into multiple sub-networks with the node to be positioned and its nearest four neighbor anchor nodes. Moreover, a hybrid particle swarm optimization and natural selection algorithm are employed to search in each sub-network to find the optimal estimated position of the node to be positioned. We evaluate and analyze the performance of NRAP under various network topologies and parameters in comparison with the many state-of-the-art works, and the results further demonstrated the superior performance than these benchmarks.
Long-term Administration of CU06-1004 Ameliorates Cerebrovascular Aging and BBB Injury in Aging Mouse Model: A Randomized Control Trial
Authors: Kim Hyejeong , Noh Minyoung , Zhang Haiying , Kim Yeomyeong , Park Songyi , Park Jeongeun , Kwon Young-Guen 
Published: July 2022

Abstract
Background
Age-related changes in the cerebrovasculature, including blood-brain barrier (BBB) disruption and vascular dementia are emerging as potential risks for many neurodegenerative diseases. Therefore, endothelial cells that constitute the cerebrovasculature play a key role in preventing brain injury. Our previous study showed that CU06-1004, endothelial cell dysfunction blocker, prevented vascular leakage and enhanced vascular integrity in ischemic reperfusion injury and normalization of tumor vasculature. Here, we evaluate the effects of CU06-1004 on age-related decline in cerebrovascular function of aged mice brain.
Results
In this study, we investigated the protective effects of CU06-1004 on reducing oxidative stress-induced damage in human brain microvascular endothelial cells (HBMECs). HBMECs were treated with hydrogen peroxide (H2O2) to establish an oxidative stress-induced cellular injury model. Pretreatment with CU06-1004 considerably reduced oxidative stress-induced cytotoxicity, ROS generation, senescence-associated β-galactosidase activity, and senescence markers in HBMECs. Additionally, pretreatment with CU06-1004 decreased the expression levels of inflammatory proteins, compared to H2O2 treatment alone. Based on the cytoprotective effect of CU06-1004 in HBMECs, we further examined the vascular protective effects of CU06-1004 on cerebrovascular aging in aged mice. Long-term administration of CU06-1004 alleviated age-associated cerebral microvascular rarefaction and cerebrovascular senescence in the aged mouse brain. CU06-1004 supplementation also reduced extravasation of plasma IgG by improving BBB integrity in the aged mouse brain. This improvement in BBB integrity was associated with reduced neuronal injury and cognition memory dysfunction in aged mice. A series of behavioral tests revealed improved motor and cognitive function in aged mice that received CU06-1004.
Conclusion
These findings suggest CU06-1004 has promise as a therapeutic for delaying age-related cerebrovascular impairment and improving cognitive function in old age.
Five-Band Millimeter-Wave Antenna of Circular/Linear Polarization for Forthcoming Generations of Mobile Handsets
Authors: Elsharkawy Rania , fawzy khalid , Farahat Asmaa 
Published: July 2022

Abstract
A compact planar antenna is proposed to operate in five millimeter-wave frequency bands at 28, 51, 55, 59, and 63 GHz. The antenna is designed to produce circular polarization at 28 GHz and linear polarization at the other four frequencies. The 28 GHz frequency band is recommended for long range communications, whereas the other four frequencies are recommended for short range communications due to the atmospheric absorption in this range of the millimeter-wave frequencies and to provide more secure communications. The reasons behind the selection of the specific values of the higher frequency bands (51, 55, 59, and 63 GHz) are (i) to provide enough number of multiple bands at such unlicensed frequency range to be used as alternatives for different applications, (ii) to give about 4 GHz separation between the center frequencies of each band and, (iii) finally, to avoid the operation at 60 GHz, in particular, due to the peak atmospheric absorption of millimeter-wave encountered at this frequency. The antenna is constructed as a square patch surrounded by five parasitic elements that are capacitively coupled to the square patch so as to realize the location of the resonant frequencies of the higher frequency bands. The antenna is fabricated and its performance is experimentally evaluated. The proposed antenna is shown to operate efficiently over the five frequency bands 28, 51, 55, 59, and 63 GHz providing impedance matching bandwidths of 2.0, 0.9, 1.2, 1.1, and 1.6 GHz, respectively. The corresponding values of the maximum gain are 7.0, 6.8, 6.0, 6.0, and 8.0 dBi, respectively. Also, the corresponding radiation efficiencies are 90%, 90%, 91%, 78%, and 86%, respectively. The 3 dB- axial ratio bandwidth at 28 GHz is about 1.2 GHz.
Effects of obesity, and of weight loss following bariatric surgery, on methylation of DNA from the rectal mucosa and in cfDNA from blood
Authors: ElGendy Khalil , Malcomson Fiona , Afshar Sorena , Bradburn Mike , Mathers John C. 
Published: July 2022

Abstract
Background
DNA methylation is an epigenetic mechanism through which environmental factors including obesity influence health. Obesity is a major modifiable risk factor for many common diseases including cardiovascular diseases and cancer. Obesity-induced inflammation resulting from aberrantly-methylated inflammatory genes may drive disease risk. This study is the first to investigate the effects of weight loss induced by bariatric surgery (BS) on DNA methylation in the rectum and in cell-free DNA (cfDNA) from blood.
Subjects and Methods:
DNA methylation was quantified in rectal mucosal biopsies and cfDNA from serum of 28 participants with obesity before and 6 months after BS, as well as in12 Non-Obese participants matched for age and sex from the Biomarkers Of Colorectal cancer After Bariatric Surgery (BOCABS) Study. DNA methylation of LEP, IL6, POMC, LINE1, MAPK7 and COX2 was quantified by pyrosequencing.
Results
BMI decreased significantly from 41.8kg/m2 pre-surgery to 32.3kg/m2 at 6 months after BS. Compared with Non-Obese participants, obesity was associated with lower LEP methylation in both the rectal mucosa and in cfDNA from serum. BS normalised LEP methylation in DNA from the rectal mucosa but not in cfDNA. BS decreased methylation of some CpG sites of LINE1 in the rectal mucosal DNA and in cfDNA to levels comparable with those in Non-Obese participants. Methylation of POMC in rectal mucosal DNA was normalised at 6 months after BS.
Conclusion
BS normalised LINE1, POMC and LEP methylation in the rectal mucosa of patients with obesity to levels similar to those in Non-Obese individuals. These findings support current evidence of effects of BS-induced weight loss on reversibility of DNA methylation in other tissues. The DNA methylation changes in the rectal mucosa shows promise as a biomarker for objective assessment of effects of weight-loss interventions on risk of cancer and other diseases.
CT-guided percutaneous microwave ablation for pulmonary metastases from colorectal cancer: Prognosis analyses based on primary tumor location
Authors: Huang Yuting , Wu Ketong , Liu Yang , Li Dan , Lai Haiyang , Peng Tao , Wan Yuan , Zhang Bo 
Published: July 2022

Abstract
Purpose
Microwave ablation (MWA) is becoming an effective therapy for inoperable pulmonary metastases from colorectal cancer (CRC). It is unclear whether the primary tumor location affects survival after MWA.
Methods
Patients who underwent MWA from 2014 to 2021 were enrolled. The survival outcomes and prognostic factors of primary CRC location were evaluated by Kaplan-Meier and Cox regression analyses.
Results
A total of 118 patients with 154 pulmonary metastases from CRC were treated in 140 MWA sessions. Rectal cancer had a higher proportion with seventy (59.32%) than colon cancer with forty-eight (40.68%). No differences were observed among age, comorbidities, number, pulmonary lobe, metatasic type, laterality, DFI, or CEA, except for sex (p = 0.001) and maximum diameter (p = 0.026). Pneumothorax was the most frequent complication and occurred in 14 (26.42%) in colon cancer and 31 (35.63%) in rectal cancer (p = 0.425). The median follow-up was 18.53 months (range 1.10-60.63 months). Kaplan-Meier analyses revealed that the DFS and OS in colon and rectal cancer were 25.97 vs 11.90 months (p = 0.405), and 60.63 vs 53.87 months (p = 0.149), respectively. Multivariate analyses showed that only age was independent prognostic factor in patients with rectal cancer (HR = 3.70, 95% CI: 1.28–10.72, p = 0.023), while none in colon cancer.
Conclusion
Primary CRC location has no impact on survival for patients with pulmonary metastases after MWA, while disparate prognostic factor exist between colon and rectal cancer. Pulmonary comorbidity may be a risk factor of survival and should be treated carefully.
Membrane integrated valorization of waste dairy whey: A novel technique
Authors: Das Pallabi , Dutta Suman , Maity Sudip 
Published: July 2022

Abstract
Experiments were undertaken to develop a sustainable, process intensified membrane integrated crystallization technique for the extraction of lactose from cheese whey. The study explored concentrative mode of membrane crystallization and its possible integration with conventional evaporative crystallization. Effects of the membrane module, mass transfer coefficient, nucleation rate, pressure drop and their interdependence were studied through modelling and system design. This was followed by exhaustive experimental investigations and parameter optimization. The effect of antisolvent addition on membrane crystallization was also explored. Following this, the membrane integrated technique was employed for selective lactose recovery from real cheese whey sourced from sweetmeat manufacturers. Competitive lactose crystal yields of 3.8- 4.96 g per 100 ml of cheese whey (from which fat & protein content was isolated) were obtained. The presence of membrane lowered the total crystallization times as compared to evaporative crystallization. Addition of antisolvent reduced crystallization times in the range of 13.5% - 23.1% for membrane integrated & chemical precipitation techniques. In the alcohol series of antisolvent dosing , a progression from methanol to butanol demonstrated enhanced reduction in crystallization. Crossflow NanoFiltration (NF) showed a higher concentration than crossflow UltraFiltration (UF). The membrane integrated crystallization technique successfully demonstrated waste valorization with competitive lactose yields from cheese whey.
Hyper-responsiveness to Warfarin in A Young Patient with The VKORC1 -1639GA/CYP2C9*1*46 Genotype: A Case Report
Authors: Aldiban Weam , Altawil Yara , Hussein Samir , Aljamali Majd , Youssef Lama A. 
Published: July 2022

Abstract
Background
Warfarin is the most widely used oral anticoagulant; nevertheless, dosing of warfarin is problematic for clinicians worldwide. Inter-individual variability in response to warfarin is attributed to genetic as well as non-genetic factors. Pharmacogenomics studies have identified variants in CYP2C9 and VKORC1 genes as significant predictors of warfarin dose, however, phenotypes of rare variants are not well characterized.
Case presentation:
We report a case of hyper-responsiveness to warfarin in a 22-year-old outpatient with Crohn's disease who presented with a swollen, red, and painful left calf. Deep venous thrombosis (DVT) in the left lower extremity was confirmed via ultrasonography, and hence, anticoagulation therapy of heparin and concomitant warfarin was initiated. Warfarin dose of 7.5 mg/day was estimated by the physician based on clinical factors. Higher than the expected international normalized ratio (INR) value of 4.5 necessitated the reduction of the warfarin dose to 5 and eventually to 2.5 mg/day to reach a therapeutic INR value of 2.6. Pharmacogenetic profiling of the VKORC1 -1639G > A and CYP2C9 *2, *3, *4, *5, *8, *14, *20, *24, *26, *33, *40, *41, *42, *43, *45, *46, *55, *62, *63, *66, *68, *72, *73 and *78 revealed a VKORC1-1639GA/CYP2C9*1*46 genotype. The lower catalytic activity of the CYP2C9*46 (A149T) variant was previously reported in in vitro settings.
Conclusions
This is the first report on a case of warfarin hyper-responsive phenotype of a patient with the heterozygous CYP2C9*1*46 polymorphism.
Roadmap towards optimal magnetic properties in rare-earth-free L10-MnAl permanent magnets
Authors: Jia Yuxiao , Wu Yuye , Xu Yichen , Zheng Ruixiao , Zhao Shiteng , Wang Jingmin , Skokov Konstantin , Maccari Fernando , Gutfleisch Oliver , Wu Haichen , Wang Hui , zou Jianxin , Jiang Chengbao 
Published: July 2022

Abstract
Twin defects deteriorate the magnetic properties in conventionally-fabricated L10-type and RETM12-type permanent magnets. Herein, we propose a strategy to suppress twins’ formation by decreasing the grain and/or particle sizes below a critical size Dt~300 nm, based on the stress relief mechanism resulting from the balance of volume/surface energy. Twin-free monocrystalline nanoparticles smaller than Dt were synthesized using a comprehensive spectrum of methods for preparing field-aligned polymer bonded magnet with high texture. We propose here a roadmap for selecting the best route for manufacturing high-performance rare-earth free MnAl magnets, depending on their grain/particle size. The dependence of coercivity on grain/particle sizes shows that optimal coercivity can be reached within the range of 50-200 nm, meanwhile, twin-free microstructure is realized which allows ultrahigh remanence by field induced texture. The results reported here can be applied to other twin-containing permanent magnet compounds, offering opportunities to drastically increase their texture and maximal energy products.
Determining Discharge Capacity of Converging Ogee spillways Using Support Vector Machine
Authors: Forudi Ali , Parsaie Abbas , Khalifehei Kamran 
Published: July 2022

Abstract
Converging ogee spillways are employed to help mitigate the natural hazards, e.g. coincidental floods. However, due to complicated nature of converging spillway hydraulics; determining governing relationships is difficult and the outcomes of the accessible conventional models is not accurate. This study concentrates on the ability of Support Vector Machine (SVM) as a Meta-model technique for estimating discharging capacity of converging ogee spillways. In this regard, two different experimental datasets were applied for simulating. To consider the models developed, two scenarios with various input combinations were dealt while scenario1 consist of two parts. Scenario1a considers only free flow condition, scenario1b considers just submerged flow properties, and scenario2 considers general flow condition including free and submerged flow dataset. The obtained results confirmed that SVM is capable of estimating the discharge capacity. It was found that for prediction discharge capacity, the SVMs performed much more accurate in free flow stage (Scenario1a) in comparison with other situations. Sensitivity analysis indicated that the ratio of the entire upstream head to the height of spillway (𝐻 / 𝑝) and downstream apron position (𝑑+ℎ𝑑 / 𝐻 ) under free flow condition, spillway geometry parameter (𝐿2/𝐿′.𝐿𝑐ℎ) on submerged flow condition, and the ratio of the entire upstream head to design head (𝐻 / 𝐻𝑑) and 𝐿2 / 𝐿′.𝐿𝑐ℎ in general flow condition plays a key role in simulating process. Comparisons among SVMs and existing relationships demonstrated that SVM models produced better outcomes.
STEAP Family Members and Gastric Cancer: Expression Profile and Prognostic Values
Authors: A Naer , Lyu Pengfei , Yu Yue , Cheng Shaohua , Liu Yunhong , Cao Xuchen 
Published: July 2022

Abstract
Background: The STEAP family is crucial in the control of metal homeostasis. A increasing amount of data suggests the link between epigenetic alterations in the STEAP family and a range of human malignancies. Nevertheless, the STEAP family's significance in gastric cancer is unclear, and there are few relevant research.Bioinformatics analysis was carried out using R software, Kaplan-Meier Plotter, cBioPortal, TIMER, LinkedOmics, STRING, Metascape, and GSCA Lite online tools.The expression of STEAP1/2/3 was dramatically upregulated in numerous tumor tissues, in particular, gastric cancer, but STEAP4 expression was significantly downregulated. Poor treatment results and aggressiveness of cancer are associated with high STEAP1/2/3 expression.Pathway analysis of the STEAP family and its co-expressed genes using Gene Ontology (GO) and Kyodo Encyclopedia of Genes and Genomes (KEGG) revealed that numerous gene terms were related with "iron ion homeostasis," "copper ion transport," "response to iron ion," and "iron ion transport." "response to iron ion," "oxidoreductase activity acting on metal ions," and "ion transport" The pathways are associated with "iron ion homeostasis," "copper ion transport," "react to iron ion," and "oxidoreductase activity involving metal ions."Notably, there was a positive correlation between STEAP 1/2/3 expression levels and oxidative stress genes,such as NOX3 and NOX4. PPI network analysis revealed that STEAP family proteins strongly interacted with TFRC. In addition, STEAP 1/2/3 expression was linked with B-cell, CD8+ T-cell infiltrating immune lymphocytes. Interestingly, Overexpression of STEAP 1/3 was also linked to decreased susceptibility of gastric cancer cells to a number of gastric cancer-targeting or chemotherapeutic drugs, including Docetaxel and Vorinostat. STEAP family members may be prognostic indicators and novel treatment targets for patients with gastric cancer.
Benchmarking the Production of Cellulose Nanofibres: Biomass Feedstock, Mechanical Processing, and Nanopaper Performance
Authors: Pennells Jordan , Chaléat Céline , Martin Darren J. 
Published: July 2022

Abstract
Lignocellulosic biomass plays a vital role in the global shift away from the utilisation of non-renewable petrochemical resources. An emerging class of biomass-derived material is nanocellulose, which are typically generated from the deconstruction of cellulose bundles within the cell wall of terrestrial and aquatic plants, either in the form of cellulose nanocrystals (CNCs) or cellulose nanofibres (CNFs). However, the utilisation of biomass has an inherent challenge associated with product variability, both in terms of the starting feedstock properties, the wide range of processing routes available to generate nanocellulose, and the fabrication of nanocellulose into a diverse range of different product formats. As a result, it is very difficult to accurately characterise and benchmark the wide variety of nanocellulose materials described within the literature. To address this challenge, this study presents a threefold benchmarking assessment of CNF material, including: (1) CNF generated from different biomass sources, including sorghum (leaf, sheath, upper stem, lower stem), banana (leaf, stem), sugarcane (mulch, bagasse), spinifex (leaf), and softwood (stem); (2) CNF generated through different mechanical processing methods, including Silverson mixing, twin screw extrusion, high energy bead milling, and high pressure homogenisation; and (3) CNF-derived nanopaper mechanical performance described within the literature and the specific energy consumption required to generate this material. The biomass benchmarking study highlighted sorghum and banana stem as the most sustainable biomass feedstock, while the mechanical process benchmarking study highlighted twin-screw extrusion as a promising low energy consumption fibrillation method. Lastly, the nanopaper benchmarking study aided in the visualisation of the nanopaper research landscape. Sample benchmarking in this manner helps to provide greater insight into the mechanisms driving nanocellulose material performance and processing sustainability.