bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ventricular arrhythmia burden and implantable cardioverter‐defibrillator outcomes in transthyretin cardiac amyloidosis
Authors: Brown Matthew T. , Yalamanchili Sreeram , Evans Sean T. , Ram Pradhum , Blank Evan A. , Lyle Melissa A. , Merchant Faisal M. , Bhatt Kunal N. 
Published: March 2022

AbstractBackgroundAs targeted treatments for amyloid transthyretin cardiomyopathy (ATTR‐CM) are becoming available, we aim to characterize the rates of ventricular arrhythmias (VAs), implantable cardioverter‐defibrillator (ICD) utilization, and their impact on survival.MethodsThis is a retrospective cohort study of 130 patients with ATTR‐CM diagnosed at Emory University's Cardiac Amyloidosis Center between April 2012 and September 2020. VAs were defined as nonsustained or sustained ventricular tachycardia and ventricular fibrillation.ResultsOf 130 patients, 42 had wild‐type disease (wtATTR) and 88 had hereditary variants (hATTR), most commonly Val122Ile (89%). At ATTR‐CM diagnosis, 80 (62%) patients had EF ≤ 40% consistent with systolic heart failure. Of the 69 (53%) patients with documented VAs significantly higher rates occurred among those with EF ≤ 40% compared with EF > 40% (67% vs. 28%, p = .001). Thirty‐two patients (25 hATTR, 7 wtATTR) had primary prevention ICDs implanted. Eight (25%) of these patients received appropriate ICD therapy while two (6%) experienced inappropriate therapy. Comparing patients with EF ≤ 35% with and without ICDs did not reveal any survival difference (3.3 ± 0.5 vs. 2.8 ± 0.4 years, p = .699).ConclusionsHigh rates of VAs and appropriate ICD therapy were found among a unique cohort of largely hereditary ATTR‐CM patients with a high rate of systolic heart failure.
Evaluation of candidate genotype of GH gene associated with growth, production and reproduction traits in Dairy Cows
Authors: Anamika  , Magotra Ankit , Bangar Yogesh C. , Malik B. S. , Garg Asha Rani 
Published: March 2022

AbstractGrowth hormone (GH) is a major regulator of postnatal growth and metabolism in mammals and plays a critical role in growth, production and fertility in cattle. The present study was conducted in dairy cattle to find the association of g.48769565 C > T mutation with growth, production and reproduction traits in Sahiwal and Hardhenu cattle. PCR‐RFLP was performed to genotype g.48769565 C > T mutation using the MspI restriction enzyme in our resource cattle population. In Hardhenu cattle, the frequencies of C and T alleles were 0.59 and 0.41, respectively, while genotypic frequencies were 0.33, 0.53 and 0.14 for CC, CT and TT respectively. The frequencies of the C and T alleles were 0.24 and 0.76, respectively, in Sahiwal cattle and it was observed that the highest frequency was for the TT genotype (0.58) and the lowest was for the CC genotype (0.06). Chi‐square analysis showed that g.48769565C>T SNP loci meet with the Hardy–Weinberg equilibrium in Sahiwal and Hardhenu cattle. From the least‐squares analysis, it was observed that CC genotype was significantly associated with total milk yield (TMY), 300 days milk yield (300D MY), lactation length (LL), dry period (DP) and artificial insemination (AI)/conception (p < .05). We also observed a significant association (p < .05) of genotype CT with 3‐month calves body weight. Cows with TT genotype revealed comparatively favourable service period (SP) and calving interval (CI) in our resource population. These observed differences in their allelic and genotypic frequencies in association with the traits underlying production and fertility can be utilized for genetic improvement in dairy cattle.
Aboveground biomass accumulation and tree size distribution in seasonal Atlantic Forest restoration sites
Authors: Arcanjo Fátima A. , Torezan José M. D. 
Published: March 2022

Tropical forests undergoing restoration can present high biomass accumulation rates, especially in the first 20 years. However, native species reforestations often present a bias toward fast growth, low wood density, and small maximum adult size species, contrasting with most mature forest species. Since tree species adult size and wood density are key traits that influence biomass accumulation, these induce uncertainty regarding carbon uptake capabilities of restoration projects in the long term. We compared the density of individuals (DI), basal area (BA), aboveground biomass (AGB), and weighted average wood density (WDW) in 13–14‐year‐old restoration sites and in mature seasonal Atlantic Forest fragments. We also assessed the contribution of pioneer and non‐pioneer and planted and non‐planted species on these variables at restoration sites. Furthermore, we investigated the DI and WDW for saplings and seedlings, in order to foresee changes in forest structure that may result from natural recruitment of dense‐wood mature species. The BA and WDW at restoration sites were similar to forest fragments, except for large trees (DBH ≥50 cm). Restoration sites recovered AGB to the level of forest fragments only for the smaller size class (DBH 5–19.9 cm). Planted pioneer and non‐pioneer species accumulated the greatest AGB (93%), BA (94%), and DI (90%) at restoration sites. The DI of non‐planted non‐pioneer species with higher WDW increased among saplings and seedlings at restoration sites. The presence of species with a larger adult size and higher WD may indicate long‐term increase in biomass accumulation at restoration sites.
Guiding Principles and Special Laws†
Authors: Díez José A. , Moulines C. Ulises 
Published: March 2022

AbstractWe analyse the structuralist notion of a guiding principle in empirical science in order to show its fruitfulness to tackle some central issues belonging both to the general as well as to the special philosophy of science, while also providing some clues to understand recent developments in the philosophy of science. We shall conclude by laying out the core characteristics of guiding principles.
Modeling Sand Particulate Flows Through Angled Apertures and Surfaces in Concentrated Solar-Thermal Power Receivers
Authors: Aurora Akarsh 
Published: March 2022

Abstract
Concentrated solar-thermal power towers are increasingly migrating toward sand-based particle receiver designs to improve thermal efficiency and reach temperatures above 1000 °C for air Brayton power cycles and supercritical CO2 power cycles. However, utilizing sand affords complexities in modeling particle flow characteristics due to variable geometric shape, size, and composition. Thus, the objective of this study is to model the particle flow characteristics of sand through variable angled chevron shapes and receiver hoppers to help formulate robust modeling for flow dynamics. Treating the chevrons as an array of apertures, a novel method of calculating sand particle mass flowrate across angled apertures and surfaces is developed. Employing high-speed photography and particle imaging velocimetry techniques, our results incorporate the impact of effective angles upon velocity, residence time, and breakage profiles of falling sand particles. This study determines that a Beverloo equation incorporating effective angles for velocity and aperture size effectively predicts mass flowrate through chevrons, which can serve as a reference for future particulate flow modeling in this field. Furthermore, increasing hopper and chevron tip angles resulted in a more significant decrease in particle diameter and curtain opacity after sand flow trials.
Nonlinear Random Vibrations Using Second-Order Adjoint and Projected Differentiation Methods
Authors: Papadimitriou Dimitrios , Mourelatos Zissimos P. , Hu Zhen 
Published: March 2022

Abstract
This paper proposes a new computationally efficient methodology for random vibrations of nonlinear vibratory systems using a time-dependent second-order adjoint variable (AV2) method and a second-order projected differentiation (PD2) method. The proposed approach is called AV2–PD2. The vibratory system can be excited by stationary Gaussian or non-Gaussian random processes following the traditional translation process model. A Karhunen–Loeve (KL) expansion expresses each input random process in terms of standard normal random variables. A second-order adjoint approach is used to obtain the required first- and second-order output derivatives accurately by solving as many sets of equations of motion (EOMs) as the number of KL random variables. These derivatives are used to compute the marginal cumulative distribution function (CDF) of the output process with second-order accuracy. Then, a second-order projected differentiation method calculates the autocorrelation function of each output process with second-order accuracy, at an additional cost of solving as many sets of EOMs as the number of outputs of interest, independently of the time horizon (simulation time). The total number of solutions of the EOM scales linearly with the number of input KL random variables and the number of output processes. The efficiency and accuracy of the proposed approach are demonstrated using a nonlinear Duffing oscillator problem under a quadratic random excitation and a nonlinear half-car suspension example.
Preconditioning Activities to Enhance Repeated High-Intensity Efforts in Elite Rugby Union Players
Authors: Vachon Adrien , Berryman Nicolas , Mujika Iñigo , Paquet Jean-Baptiste , Bosquet Laurent 
Published: March 2022

Purpose: To assess the effect of a rugby-specific high-intensity interval-training (HIITRugby) protocol on the repeated high-intensity-effort ability of young elite rugby union players and to verify the influence of 2 preconditioning sequences composed either of physical contacts (ie, tackles) or of additional runs on the magnitude of improvement. Method: Fourteen players (19 [1] y; 183.5 [8.6] cm; 95.6 [15.6] kg) underwent an HIITRugby protocol, consisting of 7 supervised training sessions over 4 weeks, each session including 3 or 4 sets of 1 to 2 minutes with 1-minute recovery. Prior to HIITRugby training, players underwent a preconditioning contact sequence or a preconditioning running sequence, to assess their influence on subsequent interval-training sessions. Results: The overall group showed a moderate improvement in total sprint time, sprints ≥90% of the best, and 20-m sprint (−3.91% [2.68%], P = .0002; 74.6% [123.7%], P = .012; −3.22% [3.13%], P = .003, respectively) and a large improvement in percentage decrement (−23.1% [20.5%], P = .005) following the 4-week training block. Relative improvements were similar between groups in total sprint time, 20-m sprint, and perceived difficulty, but the preconditioning running-sequence group exhibited a larger magnitude of gains in percentage decrement (−28.6% [20.2%] vs −17.6% [20.7%]; effect size = −1.01 vs −0.73). Conclusion: An HIITRugby training block was effective to improve repeated high-intensity-effort ability. A preconditioning contact sequence prior to HIITRugby can reduce subsequent long-interval running activity, which may attenuate the improvement of repeated high-intensity-effort indices related to the aerobic system.
Stagnation and tearing of the subducting northwest Pacific slab
Authors: Sun Muchen , Yu Youqiang , Gao Stephen S. , Liu Kelly H. 
Published: March 2022

AbstractDespite numerous observational and geodynamic modeling studies, the presence of the northwest Pacific slab tear and its influence on mantle dynamics remain controversial. By imaging the mantle transition zone (MTZ) discontinuities beneath the Japan Sea and adjacent areas, we demonstrate an ESE-WNW elongated zone with significant MTZ thinning extending from central Honshu, Japan, to the Korean Peninsula, which provides additional supporting evidence for the existence and distribution of a large-scale slab tear. Our results, when combined with other geophysical and geochemical evidence, indicate that the hot mantle material oceanward of the slab may flow through the slab tear and contribute to surface volcanism. Substantial MTZ thickening is widely observed in the region south of the slab tear and suggests the existence of slab stagnation, possibly related to the strong resistance at the bottom of the MTZ.
Effect of epidural analgesia on cancer outcomes after gastric cancer resection: a single-centre cohort study in Taiwan
Authors: Hsu Fu-Kai , Chang Wen-Kuei , Lin Kuan-Ju , Chu Tan-Ju , Fang Wen-Liang , Chang Kuang-Yi 
Published: March 2022

ObjectiveTo investigate the influence of epidural anaesthesia and analgesia (EA) on cancer recurrence and overall survival after surgery for gastric cancer.Study design and settingA retrospective study which involved patients with stage I–III gastric cancer undergoing curative resection in a medical centre from January 2012 to December 2017 and followed up until December 2019 through electronic medical chart review. Patient demographics, anaesthetic and surgical characteristics and pathologic features were also gathered.Primary and secondary outcome measuresThe effects of EA on postoperative cancer recurrence and overall survival were evaluated using proportional hazards regression models with inverse probability of treatment weighting (IPTW). Multivariable Cox regression analyses were conducted for sensitivity analysis as well.ResultsAmong the 413 patients with median follow-up of 38.5 months (IQR: 22.1–59.7), 66 (16.0%) received EA after gastric cancer surgery. EA was not associated with greater cancer recurrence (IPTW-adjusted HR: 0.55, 95% CI: 0.27 to 1.13, p=0.102) or cancer specific (IPTW- adjusted HR: 0.53, 95% CI: 0.27 to 1.04, p=0.07) and all-cause mortality (IPTW-adjusted HR: 0.65, 95% CI: 0.37 to 1.16, p=0.143) after gastric cancer resections. For sensitivity analysis, multivariable Cox regression analysis also generated non-significant EA effects on cancer recurrence and survival after surgery.ConclusionsThere was no significant association between EA and cancer recurrence or overall survival in patients with stage I–III gastric cancer receiving surgical resection of primary tumour. Prospective study should be considered to elucidate the relationship between EA and cancer outcomes after gastric cancer surgery.
Medical expenditure of women during pregnancy, childbirth and puerperium at the beginning of China’s universal two-child policy enactment: a population-based retrospective study
Authors: Zang Shuang , Zhao Meizhen , Zhu Yalan , Zhang Ying , Chen Yu , Wang Xin 
Published: March 2022

ObjectivesTo describe and explore women’s medical expenditures during pregnancy, childbirth and puerperium at the beginning of the universal two-child policy enactment in China.DesignPopulation-based retrospective study.SettingDalian, China.ParticipantsUnder the System of Health Accounts 2011 framework, the macroscopic dataset was obtained from the annual report at the provincial and municipal levels in China. The research sample incorporated 65 535 inpatient and outpatient records matching International Classification of Diseases, 10th Revision codes O00–O99 in Dalian city from 2015 through 2017.Primary and secondary outcome measuresThe study delineates women’s current curative expenditure (CCE) during pregnancy, childbirth and puerperium at the beginning of the universal two-child policy in China. The temporal changes of medical expenditure of women during pregnancy, childbirth and puerperium at the beginning of China’s universal two-child policy enactment were assessed. The generalised linear model and structural equation model were used to test the association between medical expenditure and study variables.ResultsUnlike the inverted V-shaped trend in the number of live newborns in Dalian over the 3 studied years, CCE on pregnancy, childbirth and puerperium dipped slightly in 2016 (¥260.29 million) from 2015 (¥263.28 million) and saw a surge in 2017 (¥288.65 million). The ratio of out-of-pocket payment/CCE reduced year by year. There was a rapid increase in CCE in women older than 35 years since 2016. Length of stay mediated the relationship between hospital level, year, age, reimbursement ratio and medical expenditure.ConclusionsThe rise in CCE on pregnancy, delivery and puerperium lagged 1 year behind the surge of newborns at the beginning of China’s universal two-child policy. Length of stay acted as a crucial mediator driving up maternal medical expenditure. Reducing medical expenditure by shortening the length of stay could be a feasible way to effectively address the issue of cost in women during pregnancy, childbirth and puerperium.
Effectiveness of educational interventions to develop patient safety knowledge, skills, behaviours and attitudes in undergraduate nursing students: a systematic review protocol
Authors: De Rezende Helena , Vitorio Aline Mirema F , Morais Alexandre Souza , Garzin Ana Claudia A , Nicole Andressa Garcia , Quadrado Ellen Regina Sevilla , Lourenção Daniela Campos de Andrade , Martins Maristela Santini 
Published: March 2022

IntroductionPatient safety is a healthcare discipline that aims to prevent and reduce patient harm, risks and errors during the provision of healthcare. Given the size of the nursing workforce in the healthcare system the inclusion of patient safety in the undergraduate nursing curriculum is necessary to enhance a safe culture in the daily work of their future careers. To this end, it is essential to apply effective teaching strategies to develop patient safety competencies. This review will aim to evaluate the effectiveness of educational interventions in developing patient safety knowledge, skills, behaviours and attitudes in undergraduate nursing students within the existing topic areas of the WHO Multi-professional Patient Safety Curriculum Guide.Methods and analysisThe databases Medline, CINAHL, Scopus, Education Research Complete, The Cochrane Central Register of Controlled Trials, LILACS, Medes and Grey literature such as ClinicalTrials.gov, Google Scholar, DART-Europe, ProQuest Dissertations, CAPES thesis and dissertations, The Virginia Henderson Global e-Repository, Mednar and Thesis Canada will be searched from July 2011 to January 2022. Two independent reviewers will conduct the search, extract the data and assess the risk of bias for the included studies, using standardised critical appraisal instruments from the Joanna Briggs Institute. The quality of the evidence will be assessed using the Grading of Recommendations, Assessment Development and Evaluation methodology. Studies will be pooled in the meta-analysis. Alternatively, the findings will be presented in narrative form, including tables and figures, to aid in data presentation.Ethics and disseminationThis study raises no ethical issues. The findings will be disseminated through presentations at professional conferences and publications in a peer-reviewed journal.PROSPERO registration numberCRD42021254965.
Clarity and applicability of adverse drug reaction-related monitoring instructions in clinical practice guidelines for children and adolescents treated with antipsychotic drugs: a review of six clinical practice guidelines
Authors: Minjon Lenneke , Aarts Juul W , van den Ban Els , Egberts Toine CG , Heerdink Eibert R 
Published: March 2022

ObjectivesMonitoring instructions related to adverse drug reactions (ADRs) are not always clearly described in clinical practice guidelines (CPGs) and not always easily applicable in daily clinical practice. The aim of this study was to assess the clarity of presentation and the applicability of ADR-related monitoring instructions in CPGs for children and adolescents treated with antipsychotic drugs.SettingGuidelines from different countries were selected, and monitoring instructions for 13 ADR-related parameters were assessed.Primary and secondary outcome measuresTo assess the clarity and the applicability of the sections concerning monitoring instructions in each CPG, the Appraisal of Guidelines for Research and Evaluation instrument was used. To assess the clarity and the applicability of the monitoring instructions for each ADR-related parameter, the Systematic Information for Monitoring score was used.ResultsSix CPGs were included. Overall, the presentation of the monitoring instructions in the different CPGs was clear; three CPGs scored >75%. All CPGs scored lower on applicability, as, for example, the barriers and facilitators were poorly described. The number of ADR-related parameters included in the CPGs varied between 8 and 13. Why and what to monitor was always described for each parameter. When to start monitoring was also often described (90.2%), but when to stop monitoring was less frequently described (37.4%).ConclusionsThe CPGs differed on the parameters that needed to be monitored. Overall, the monitoring instructions were clearly presented, but improvement in their applicability is required. By improving the monitoring instructions, CPGs can provide better guidance on monitoring ADRs in daily clinical practice.
Randomised comparative effectiveness trial of Pulmonary Embolism Prevention after hiP and kneE Replacement (PEPPER): the PEPPER trial protocol
Authors: Pellegrini, Jr Vincent D , Eikelboom John William , Evarts C McCollister , Franklin Patricia D , Garvin Kevin L , Goldhaber Samuel Z , Iorio Richard , Lambourne Carol Ann , Magaziner Jay , Magder Laurence 
Published: March 2022

IntroductionMore than 1 million elective total hip and knee replacements are performed annually in the USA with 2% risk of clinical pulmonary embolism (PE), 0.1%–0.5% fatal PE, and over 1000 deaths. Antithrombotic prophylaxis is standard of care but evidence is limited and conflicting. We will compare effectiveness of three commonly used chemoprophylaxis agents to prevent all-cause mortality (ACM) and clinical venous thromboembolism (VTE) while avoiding bleeding complications.Methods and analysisPulmonary Embolism Prevention after HiP and KneE Replacement is a large randomised pragmatic comparative effectiveness trial with non-inferiority design and target enrolment of 20 000 patients comparing aspirin (81 mg two times a day), low-intensity warfarin (INR (International Normalized Ratio) target 1.7–2.2) and rivaroxaban (10 mg/day). The primary effectiveness outcome is aggregate of VTE and ACM, primary safety outcome is clinical bleeding complications, and patient-reported outcomes are determined at 1, 3 and 6 months. Primary data analysis isper protocol, as preferred for non-inferiority trials, with secondary analyses adherent tointention-to-treatprinciples. All non-fatal outcomes are captured from patient and clinical reports with independent blinded adjudication. Study design and oversight are by a multidisciplinary stakeholder team including a 10-patient advisory board.Ethics and disseminationThe Institutional Review Board of the Medical University of South Carolina provides central regulatory oversight. Patients aged 21 or older undergoing primary or revision hip or knee replacement are block randomised by site and procedure; those on chronic anticoagulation are excluded. Recruitment commenced at 30 North American centres in December 2016. Enrolment currently exceeds 13 500 patients, representing 33% of those eligible at participating sites, and is projected to conclude in July 2024; COVID-19 may force an extension. Results will inform antithrombotic choice by patients and other stakeholders for various risk cohorts, and will be disseminated through academic publications, meeting presentations and communications to advocacy groups and patient participants.Trial registrationNCT02810704.