bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triboresistive Touch Sensing: Grid‐Free Touch‐Point Recognition Based on Monolayered Ionic Power Generators
Authors: Lee Younghoon , Lim Sungsoo , Song Won Jun , Lee Sudong , Yoon Sohee John , Park Jae‐Man , Lee Min‐Gyu , Park Yong‐Lae , Sun Jeong‐Yun 
Published: March 2022

AbstractRecent growing pursuit of skin‐mountable devices has been impeded by the complicated structures of most sensing systems, containing electrode grids, stacked multilayers, and even external power sources. Here, a type of touch sensing, termed “triboresistive touch sensing”, is introduced for gridless touch recognition based on monolayered ionic power generators. A homogeneous monolayer, i.e., ionic poly(dimethylsiloxane) (PDMS), generates electricity based on the electric field generated by touch. Voltages generated at each corner of the ionic PDMS rely on resistance between touch points and each corner, ensuring recognition of the touch positions without the need for electrode grid layers and external power sources. With notable advantages of high transparency (96.5%), stretchability (539.1%), and resilience (99.0%) of the ionic PDMS, epidermal triboresistive sensing is demonstrated to express touch position and readily play a musical instrument. A gridless system of triboresistive sensing allows rearrangement of the touch sections according to a given situation without any physical modification, and thus easily completes consecutive missions of controlling position, orientation, and gripping functions of a robot.
12.42% Monolithic 25.42 cm2 Flexible Organic Solar Cells Enabled by an Amorphous ITO‐Modified Metal Grid Electrode
Authors: Han Yunfei , Hu Zishou , Zha Wusong , Chen Xiaolian , Yin Li , Guo Jingbo , Li Zhiyun , Luo Qun , Su Wenming , Ma Chang‐Qi 
Published: March 2022

AbstractPrinted metal nanogrid electrode exhibits superior characteristics for use in flexible organic solar cells (OSCs). However, the high surface roughness and inhomogeneity between grid and blank region is adverse for performance improvement. In this work, a thin amorphous indium tin oxide (ITO) film (α‐ITO) is introduced to fill the blank and to improve the charge transporting. The introduction of α‐ITO significantly improves the comprehensive properties of metal grid electrode, which exhibits excellent bending resistance and long‐term stability under double 85 condition (under 85 °C and 85% relative humidity) for 200 h. Both experimental and simulation results reveal α‐ITO with a sheet resistance of 20 000 Ω □−1 is sufficient to improve the charge transporting within the adjacent grids, leading to a remarkable efficiency of 16.54% for 1 cm2 flexible devices. With area increased to 4.00, 9.00, and 25.42 cm2, the devices still display a performance of 16.22%, 14.69%, and 12.42%, respectively, showing less efficiency loss during upscaling. And the 25.42 cm2 monolithic flexible device exhibits a certificated efficiency of 12.03%. Moreover, the device shows significantly improved air stability relative to conventional high‐conductive poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate‐modified device. All these make the α‐ITO‐modified Ag/Cu electrode promise to achieve high‐efficient and long‐term stable large‐area flexible OSCs.
Enzyme‐Engineered Conjugated Polymer Nanoplatform for Activatable Companion Diagnostics and Multistage Augmented Synergistic Therapy
Authors: Wu Jiayingzi , Zhang Yafei , Jiang Kejia , Wang Xiaoyu , Blum Nicholas Thomas , Zhang Jing , Jiang Shanshan , Lin Jing , Huang Peng 
Published: March 2022

AbstractCompanion diagnostics (CDx) provides critical information for precision medicine. However, current CDx is mostly limited to in vitro tests, which cannot accurately evaluate the disease progression and treatment response in real time. To overcome this challenge, herein a glucose oxidase (GOx)‐engineered conjugated polymer (polyaniline, PANI) nanoplatform (denoted as PANITG) is reported for activatable imaging‐based CDx and multistage augmented photothermal/starvation synergistic therapy. PANITG comprises a pH‐activatable conjugated polymer as a photothermal convertor and photoacoustic (PA) emitter, a GOx as a cancer starvation inducer as well as a H2O2 and acid producer, and a H2O2‐cleavable linker as a “switch” for GOx activity. The in vivo PA imaging and photothermal therapy abilities are activated by acidic tumor microenvironment and self‐augmented by the reaction between GOx and glucose. Meanwhile, the photothermal effect will enhance the GOx activity in turn. Such multistage augmentation of the therapeutic effects will facilitate effective cancer management. In addition, the in vivo PA imaging with PANITG reveals the tumor pH level which is correlated to the efficiency of the photothermal therapy and to the catalytic activity of GOx at each stage, enabling real‐time activatable CDx.
Novel Approach to Track the Lifecycle of Inflammation from Chemokine Expression to Inflammatory Proteins in Sweat Using Electrochemical Biosensor
Authors: Jagannath Badrinath , Pali Madhavi , Lin Kai‐Chun , Sankhala Devangsingh , Naraghi Pejman , Muthukumar Sriram , Prasad Shalini 
Published: March 2022

AbstractInflammatory biomarkers are modulated during the course of any infectious disease, and currently, there is no wearable technology that enables patient management through noninvasive monitoring of these markers. This work is the first demonstration of the discovery and quantification of interferon‐inducible protein (IP‐10) and tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL), two key prognostic markers of infection in human sweat. The levels of IP‐10 and TRAIL in sweat are quantified, validated, and confirmed using a standard reference method through preclinical human subject studies. Additionally, simultaneous and continuous detection of IP‐10, TRAIL, and C‐reactive protein (CRP), for infection monitoring in sweat using a wearable SWEATSENSER device is demonstrated. The SWEATSENSER is ultrasensitive with a limit of detection of 1 pg mL−1 (IP‐10 and TRAIL), 0.2 ng mL−1 (CRP) with a wide dynamic range. Bland–Altman analysis demonstrates good agreement between SWEATSENSER and standard reference methods through human subject studies. Serum to sweat relationship demonstrates the potential of the SWEATSENSER to track infection etiology.
A Highly Stable Li‐Organic All‐Solid‐State Battery Based on Sulfide Electrolytes
Authors: Zhou Xing , Zhang Yu , Shen Ming , Fang Zhong , Kong Taoyi , Feng Wuliang , Xie Yihua , Wang Fei , Hu Bingwen , Wang Yonggang 
Published: March 2022

AbstractSulfide solid electrolytes with high conductivity that is close to that of liquid electrolyte have been considered to be one of the most promising electrolytes for all‐solid‐state lithium batteries (ASSLBs). Unfortunately, the narrow electrochemical windows of sulfide electrolyte and contact loss at the interface upon cycles much limits the application of sulfide‐based ASSLBs. In this work, an organic quinone cathode, 5,7,12,14‐pentacenetetrone (PT), is used to fabricate an ASSLB with a sulfide electrolyte of glass ceramic 70Li2S‐30P2S5 (LPS). Based on the various in situ/ex situ analyses, it is successfully demonstrated that the decomposition of LPS is negligible and the corresponding effects on interfacial impedance are reversible with optimized carbon additives. In addition, the inherent low Young's modulus of the PT electrode efficiently prevents the contact loss at the interface. As a result, the PT‐based ASSLBs deliver a high specific capacity (312 mAh g−1) and an excellent capacity retention (90.6%) over 500 cycles which is superior to previous reports. Moreover, a carbon‐free ASSLB is constructed by employing Mo6S8 as conductive additives in a PT‐based cathode, which shows an improved rate performance and a long life.
Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2
Authors: Ali Farak , Alom Shahnaz , Shakya Anshul , Ghosh Surajit K. , Singh Udaya P. , Bhat Hans R. 
Published: March 2022

AbstractCorona Virus Disease‐19 (COVID‐19) is a pandemic disease mainly caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). It had spread from Wuhan, China, in late 2019 and spread over 222 countries and territories all over the world. Earlier, at the very beginning of COVID‐19 infection, there were no approved medicines or vaccines for combating this disease, which adversely affected a lot of individuals worldwide. Although frequent mutation leads to the generation of more deadly variants of SARS‐CoV‐2, researchers have developed several highly effective vaccines that were approved for emergency use by the World Health Organization (WHO), such as mRNA‐1273 by Moderna, BNT162b2 by Pfizer/BioNTech, Ad26.COV2.S by Janssen, AZD1222 by Oxford/AstraZeneca, Covishield by the Serum Institute of India, BBIBP‐CorV by Sinopharm, coronaVac by Sinovac, and Covaxin by Bharat Biotech, and the first US Food and Drug Administration‐approved antiviral drug Veklury (remdesivir) for the treatment of COVID‐19. Several waves of COVID‐19 have already occurred worldwide, and good‐quality vaccines and medicines should be available for ongoing as well as upcoming waves of the pandemic. Therefore, in silico studies have become an excellent tool for identifying possible ligands that could lead to the development of safer medicines or vaccines. Various phytoconstituents from plants and herbs with antiviral properties are studied further to obtain inhibitors of SARS‐CoV‐2. In silico screening of various molecular databases like PubChem, ZINC, Asinex Biol‐Design Library, and so on has been performed extensively for finding effective ligands against targets. Herein, in silico studies carried out by various researchers are summarized so that one can easily find the best molecule for further in vitro and in vivo studies.
Recent green approaches for the synthesis of pyrazolo[3,4‐d]pyrimidines: A mini review
Authors: Maher Mai , Zaher Ashraf F. , Mahmoud Zeinab , Kassab Asmaa E. 
Published: March 2022

AbstractPyrazolo[3,4‐d]pyrimidine as a bioisostere of purine has drawn considerable attention as a privileged scaffold for the design and discovery of novel drugs. Green synthesis is an emerging area in the field of chemistry that provides economic and environmental benefits as an alternative to traditional methods. The present mini review reflects recent advances in the green synthesis of pyrazolo[3,4‐d]pyrimidines, published in the time frame from 2006 to 2019.
Viscosity Effects on Excited‐State Dynamics of Indocyanine Green for Phototheranostic
Authors: Liao Keyue , Pan Yonghui , Wu Zizi , Yao Weiyun , Miao Xiaofei , Lu Xiaomei , Fan Quli , Hu Wenbo 
Published: March 2022

AbstractThe excited‐state dynamics of indocyanine green (ICG) fundamentally determine its photophysical properties for phototheranostic. However, its dynamics are predictable to be susceptible toward intracellular viscosity due to its almost freely rotating structure, making the precise phototheranostic very challenging. Therefore, correlating the viscosity with the dynamics of ICG is of great importance and urgency for precise phototheranostic prospects. This study presents systemic investigations on the viscosity‐dependent dynamics of ICG for phototheranostic. Femtosecond transient absorption (fs‐TA) experiments elucidate a prolonged radiative transition (225 psvs152 ps) for ICG in a viscous environment, which benefits fluorescence. High viscosity remarkably extends the triplet excited‐state lifetime of ICG but reduces its internal conversion (6.2 psvs2.2 ps). The extended triplet lifetime affords sufficient photosensitization time to enhance photodynamic therapy. A moderative internal conversion is unfavorable for heat production, resulting in inferior photothermal therapy. With this clear picture of excitation energy state dissipation in mind, we readily identified the safety laser power density for precise phototheranostic. This work provides an insightful understanding of viscosity‐relevant excited‐state dynamics toward phototheranostic, which is also beneficial for designing novel ICG derivatives with improved phototheranostic performance.
Early measurement of autism risk constructs in the general population: A new factor structure of the First Years Inventory (FYIv3.1) for ages 6–16 months
Authors: Baranek Grace T. , Sideris John , Chen Yun‐Ju , Crais Elizabeth R. , Turner‐Brown Lauren , Watson Linda R. 
Published: March 2022

AbstractEarly detection of autism risk in the community is critical to increasing families' access to early intervention, yet few measures have been developed and tested for the general population of infants <16 months to tap a broader range of autism risk constructs. This study aimed to (a) examine the factor structure of the First Years Inventory, version 3.1 (FYIv3.1), with a sample of 6454 infants 6–16 months, and (b) determine the ability of the resulting factors to discriminate clinical outcome groups at 3 years of age. The FYIv3.1 is a parent‐report tool designed to detect early behavioral risk signs that may be associated with a later diagnosis of ASD and related neurodevelopmental conditions. Factor analytic models were used to determine the number of constructs and inter‐factor correlations. Findings supported a seven‐factor structure: communication, imitation and play (CIP); social attention and affective engagement (SAE); sensory hyperresponsiveness (HYPER); sensory hyporesponsiveness (HYPO); self‐regulation in daily routines (SREG); sensory interests, repetitions, and seeking behaviors (SIRS); motor coordination and milestones (MCM). Mean comparisons on these factors demonstrated significant discrimination of the three outcome groups at age 3 years including those classified as having an ASD diagnosis and/or high autism symptoms, those classified as having other developmental disorders/conditions/concerns, and those classified with no known conditions/concerns. These findings support the validity and multidimensionality of early ASD risk constructs, as well as the potential use of the FYIv3.1 for phenotypic subtyping in the general population, and early detection in a broader age range of 6–16 months in future clinical studies.Lay SummaryThe FYIv3.1 is a 69‐item parent‐report questionnaire about infant behaviors that may indicate an elevated likelihood for later neurodevelopmental conditions such as autism. Analyses of responses from 6454 parents of infants 6–16 months indicated that items could be grouped reliably into seven categories. Compared to children with or without other developmental conditions, children in the outcome group with autism spectrum disorder and/or high autism symptoms at age three showed more behavioral risk signs in social‐communication, sensory, and motor domains during infancy.
Myelodysplastic syndrome in a case of new‐onset pancytopenia
Authors: Lancaster Ian , Patel Deep , Sethi Vikas , Connelly Weston , Namey Joseph 
Published: March 2022

AbstractMyelodysplastic syndrome (MDS) is an infrequent cause of pancytopenia, which is a decrease in all three peripheral blood cell lines. We report the case of new‐onset pancytopenia following administration of a COVID‐19 vaccine and recurrent Zosyn use who was later found to have myelodysplastic syndrome.
Gitelman syndrome, hypomagnesemia, and venous thrombosis: An intriguing association
Authors: Chargui Soumaya , Houli Rawnak , Ounissi Mondher , Ben Hamida Fethi , Harzallah Amel , Abderrahim Ezzeddine 
Published: March 2022

AbstractAmong salt‐wasting tubulopathies' complications, venous thrombosis is one of the rarest. We report a case of a young woman with Gitelman syndrome (GS). She presented a deep venous thrombosis in her leg and was treated with heparin with favorable outcomes. We retained hypomagnesemia as the cause of the thrombosis.
Friction on I‐Modified Au(111) in a Tetraglyme Electrolyte
Authors: Park Inhee , Hausen Florian , Baltruschat Helmut 
Published: March 2022

AbstractIn situ electrochemical lateral force microscopy (EC‐LFM) has been employed to study the ordered structure of Li+ containing tetraglyme (G4) in front of I‐modified Au(111) and its influence on friction as function of normal load. Since the effect of water in aprotic electrolytes is a critical issue, the influence of water on the ordered structure and friction was also been investigated. Lateral force maps recorded at low normal load (FN<30 nN) show that the adsorbed iodine forms a
structure (
independent of potential. With increasing normal load, observed atomic corrugations at both potentials (0.45 V and −0.4 V) are in agreement with the Au(111) (
structure while returning to a
structure with decreasing normal load. Thus we conclude that the AFM tip penetrates into the iodine adlayer without irreversible wear. Astonishingly, no clear friction increase was observed upon penetration into the iodine adlayer; also no corresponding step was found in force separation (FS) curves. On the other hand, FS curves for I‐modified Au(111) in pure G4 solvent and Li+ containing electrolyte clearly showed several steps suggesting that G4 molecules are forming up to five ordered layers. It is noteworthy that we observed two different push‐through forces for the innermost layers. Considering the higher reproducibility of FS curves on I‐modified Au(111) compared to bare Au(111) we assume that the low surface energy of the iodine monolayer leads to negligible interaction between G4 molecules and iodine adlayer, resulting in less perturbations of the structure by the solid phase and also an increase of push‐through force. Charts of friction forces vs. normal load are found to be independent of applied potential and the concentration of water.
Novel Thienyl DPP derivatives Functionalized with Terminal Electron‐Acceptor Groups: Synthesis, Optical Properties and OFET Performance
Authors: Fusco Sandra , Barra Mario , Gontrani Lorenzo , Bonomo Matteo , Chianese Federico , Galliano Simone , Centore Roberto , Cassinese Antonio , Carbone Marilena , Carella Antonio 
Published: March 2022

AbstractThree novel diketopyrrolopyrrole (DPP) based small molecules have been synthesized and characterized in terms of their chemical‐physical, electrochemical and electrical properties. All the molecules consist of a central DPP electron acceptor core symmetrically functionalized with donor bi‐thienyl moieties and flanked in the terminal positions by three different auxiliary electron‐acceptor groups. This kind of molecular structure, characterized by an alternation of electron acceptor and donor groups, was purposely designed to provide a significant absorption at the longer wavelengths of the visible spectrum: when analysed as thin films, in fact, the dyes absorb well over 800 nm and exhibit a narrow optical bandgap down to 1.28 eV. A detailed DFT analysis provides useful information on the electronic structure of the dyes and on the features of the main optical transitions. Organic field‐effect transistors (OFETs) have been fabricated by depositing the DPP dyes as active layers from solution: the different end‐functionalization of the dyes had an effect on the charge‐transport properties with two of the dyes acting as n‐type semiconductors (electron mobility up to 4.4 ⋅ 10−2 cm2/V ⋅ s) and the third one as a p‐type semiconductor (hole mobility up to 2.3 ⋅ 10−3 cm2/V ⋅ s). Interestingly, well‐balanced ambipolar transistors were achieved by blending the most performant n‐type and p‐type dyes with hole and electron mobility in the order of 10−3 cm2/V ⋅ s
Genetic Optimization of Homogeneous Catalysts
Authors: Laplaza Ruben , Gallarati Simone , Corminboeuf Clemence 
Published: March 2022

AbstractWe present the NaviCatGA package, a versatile genetic algorithm capable of optimizing molecular catalyst structures using well‐suited fitness functions to achieve a set of targeted properties. The flexibility and generality of this tool are validated and demonstrated with two examples: i) Ligand optimization and exploration for Ni‐catalyzed aryl‐ether cleavage manipulating SMILES and using a fitness function derived from molecular volcano plots, ii) multi‐objective (i. e., activity/selectivity) optimization of bipyridineN,N‐dioxide Lewis basic organocatalysts for the asymmetric propargylation of benzaldehyde from 3D molecular fragments. We show that evolutionary optimization, enabled by NaviCatGA, is an efficient way of accelerating catalyst discovery through bypassing combinatorial scaling issues and incorporating compelling chemical constraints.
Synthesis of Alloyed Pd−Pb Nanowire Networks for Electrocatalytic Ethanol Oxidation with High Stability
Authors: Gao Fahui , Fu Bei , Xu Luyao , Yang Likang , Guo Peizhi 
Published: March 2022

AbstractNowadays, with the importance of energy problems, alloyed palladium‐based electrocatalysts in low‐dimension have become more and more popular in electrocatalysis. Here Pd−Pb nanowire networks (NNWs) were synthesized hydrothermally with different Pd/Pb molar ratios from 8 : 1 to 3 : 1 and they exhibited excellent electrochemical performance toward ethanol oxidation reaction (EOR). Pd6Pb1 NNW presented the network structure along with the smallest diameter and exhibited a high catalytic activity, excellent stability and great toxicity resistance toward EOR in alkaline conditions. The catalytic current density of the Pd6Pb1 NNW for EOR under alkaline conditions was 2344 mA mg−1, while 2174, 1936 and 1728 mA mg−1 for Pd8Pb1, Pd4Pb1 and Pd3Pb1 NNWs, respectively. It was worth mentioning that Pd6Pb1 NNW had a low activity loss and ended with 92.9% of its own maximum current density after 300 cycling, much better than that of commercial Pd/C. The positive correlation effects of catalytic temperatures and concentrations of KOH and/or ethanol concentrations for Pd−Pb NNWs were observed and discussed based on the electrochemical measurements.
Digitalization of visual discrimination threshold and acceptable tolerance of color depth by psychophysical experiments
Authors: Yang Hongying , Qi Mengyuan , Yang Zhihui , Xie Wanzi , Zhang Jingjing , Feng Nuoya 
Published: March 2022

AbstractColor depth is of great importance to both dyes and dyeing. The assessments of properties such as color fastness, relative dye strengths require dyed fabric to be adjusted to a specific depth level. However, the study of discrimination threshold and acceptable tolerance of color depth is limited. In this study, we attempted to investigate them. Acceptability (Pass/Fail) psychophysical visual experiments were performed twice by 16 normal color version observers on approximately 1206 samples for 6 standard depths in 3 hues, yielding approximately 40,000 visual assessment data points. The color depth formula, Yang3, which performed best in linearity to color depth in a previous study, was selected to calculate the color depth values YCD3 of the samples. The calculated and the visual data were bridged statistically. Experimental results show that the average discrimination threshold and acceptable tolerance of color depth are approximately 0.45 and 2.15 in YCD3, respectively. Furthermore, the details of different hues, lighter and deeper, male and female perspectives were analyzed and discussed. The Yang3 formula exhibited uniformity at different standard depths, as expected.