bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodological guidance for rapid reviews in healthcare: A scoping review
Authors: Speckemeier Christian , Niemann Anja , Wasem Jürgen , Buchberger Barbara , Neusser Silke 
Published: March 2022

AbstractThe aim of the present work was to identify published methodological guidance for rapid reviews (RRs) and to analyze the recommendations with regard to time‐saving measures. A literature search was performed in PubMed and EMBASE in November 2020. In addition, a search based on Google Scholar and websites of governmental and non‐governmental organizations was conducted. Literature screening was carried out by two researchers independently. A total of 34 publications were included. These describe 38 distinct RR types. The timeframe to complete the identified RR types ranges from 24 h to 6 months (mean time 2.2 months). For most RR types a specific research question (n = 21) and a prioritizing search (n = 25; preference for e.g., systematic reviews and meta‐analyses) is employed. Different approaches such as reduced personnel in literature screening (n = 21) and data extraction (n = 21) are recommended. The majority of RR types include a bias assessment (n = 28) and suggest a narrative report focusing on safety and efficacy. The included RR types are heterogeneous in terms of completion time, considered domains and strategies to alter the standard systematic review methods. A rationale for the recommended shortcuts is rarely presented.
Short‐term treatment with zingerone ameliorates dextran sulfate sodium‐induced mouse experimental colitis
Authors: Zhang Zecai , Cui Yueqi , Liu Siyu , Huang Jiang , Liu Yu , Zhou Yulong , Zhu Zhanbo 
Published: March 2022

AbstractBACKGROUNDUlcerative colitis (UC) is a relapsing and chronic inflammatory disease of the gastrointestinal tract, which seriously threatens human health. Zingerone (ZO) has been proven to be effective for many diseases. The purpose of this study is to investigate the protective effects and potential mechanisms of ZO extracted from ginger on dextran sulfate sodium (DSS)‐induced mouse ulcerative colitis (UC).RESULTSThe results showed that ZO alleviated the weight loss of UC model mice, reduced the disease activity index scores, and inhibited the shortening of colon length. ZO also improved DSS‐induced pathological changes in colon tissue and inhibited the secretion of pro‐inflammatory cytokines in colon and mesenteric lymph nodes. Further mechanism analysis found that ZO inhibited DSS‐induced nuclear factor‐κB pathway activation, and regulated peroxisome proliferator‐activated receptor γ (PPARγ) expression. To further explore whether PPARγ was involved in the anti‐UC effect of ZO, PPARγ inhibitor GW9662 was used. Although ZO also showed a protective effect on GW9662‐treated colitis mice, the protective role was significantly weakened. Importantly, the administration of GW9662 significantly aggravated UC compared with the ZO + DSS group. In addition, we preliminarily found that ZO had the effects of inhibiting DSS‐induced oxidative stress, maintaining intestinal barrier, and inhibiting the content of LPS and the population of Escherichia coli.CONCLUSIONSThese results indicated that supplementation with ZO might be a new dietary strategy for the treatment of UC. © 2022 Society of Chemical Industry.
Physical and oxidative stability of astaxanthin microcapsules prepared with liposomes
Authors: Zhao Xu , Wang Kaili , Zhao Jiale , Sun Rongbo , Shang Hang , Sun Chuanqiang , Liu Liangwei , Hou Juncai , Jiang Zhanmei 
Published: March 2022

AbstractBACKGROUNDOil bodies (OBs) are a kind of natural and stable oil nucleate microcapsule in which the triglyceride matrix can be used as an appropriate carrier of hydrophobic molecules. Astaxanthin has high antioxidant properties but is extremely sensitive to oxidation, causing the loss of its bioactive properties.RESULTSThe purpose of this study was to clarify the effects of environmental factors (light, oxygen, temperature, and pH) on the physical and oxidative stability of astaxanthin microcapsules prepared with peanut oil bodies (POBs). After 14 days of storage, the retention rate of astaxanthin in peanut oil microcapsules (POMs) was significantly increased. The astaxanthin retention rate of POMs stored under light conditions was higher than under dark conditions. Similarly, the retention rate of astaxanthin in POMs was significantly increased during vacuum storage. The astaxanthin retention rate was also the highest when POMs were stored at 4 °C, whereas it was the lowest at pH 3.0.CONCLUSIONThe experiment demonstrated that microcapsulation could improve the astaxanthin retention rate and storage stability, and recombinant OBs were potential ideal wall materials for astaxanthin embedding. © 2022 Society of Chemical Industry
Effect of microporous polysaccharide hemospheres on anterolateral thigh free flap donor site complications
Authors: David Abel P. , Zebolsky Aaron L. , Park Andrea M. , Heaton Chase M. , Knott P. Daniel , Seth Rahul 
Published: March 2022

AbstractBackgroundPostoperative seroma is the most common donor site complication following anterolateral thigh (ALT) free flap harvest for head and neck reconstruction. The utility of novel microporous polysaccharide hemospheres (MPH) has not been studied as a hemostatic agent in this setting.MethodsProspective, single‐blind, randomized controlled trial of patients undergoing fasciocutaneous ALT harvest for head and neck reconstruction at a tertiary academic medical center between April 2018 and February 2020. The intervention (MPH) group received 3 g of topical MPH to the ALT donor site prior to closure whereas the control group did not receive application of MPH. Outcomes included total drain output (ml), drain output during postoperative days (POD) 1–3 alone, drain duration (days), and incidence of donor site hematoma, seroma, or infection.ResultsTwenty‐nine patients were randomized to the MPH group and 26 to the control group. For MPH and control groups, mean total drain output was 284.7 ± 153.0 ml versus 317.9 ± 177.6 ml (p = .527), mean POD 1–3 drain output alone was 169.3 ± 88.8 ml versus 157.9 ± 78.7 ml (p = .749), and drain duration was 5.9 ± 1.5 days versus 6.5 ± 1.6 days (p = .144), respectively. There was no significant difference in seroma (p = .733), hematoma (p = .492), or infection (p = 1.000). Drain output was not significantly influenced by gender, age, body weight, or smoking habits.ConclusionMPH administration to ALT free flap donor sites did not significantly improve drain output, hematoma formation, or seroma formation.Level of Evidence 2
Phosphorus‐Containing Polymeric Zwitterion: A Pioneering Bioresponsive Probe for 31P‐Magnetic Resonance Imaging
Authors: Kracíková Lucie , Ziółkowska Natalia , Androvič Ladislav , Klimánková Iveta , Červený David , Vít Martin , Pompach Petr , Konefał Rafał , Janoušková Olga , Hrubý Martin , Jirák Daniel , Laga Richard 
Published: March 2022

Abstract31P‐magnetic resonance (MR) is an important diagnostic technique currently used for tissue metabolites assessing, but it also has great potential for visualizing the internal body structures. However, due to the low physiological level of phosphorus‐containing biomolecules, precise imaging requires the administration of an exogenous probe. Herein, this work describes the synthesis and MR characterization of a pioneering metal‐free 31P‐MR probe based on phosphorus‐containing polymeric zwitterion. The developed probe (pTMPC) is a well‐defined water‐soluble macromolecule characterized by a high content of naturally rare phosphorothioate groups providing a high‐intensity 31P‐MR signal clearly distinguishable from biological background both in vitro and in vitro. In addition, pTMPC can serve as a sensitive 31P‐MR sensor of pathological conditions in vivo because it undergoes oxidation‐induced structural changes in the presence of reactive oxygen species (ROS). Add to this the favorable 1H and 31P T1/T2 relaxation times and biocompatibility, pTMPC represents a conceptually new diagnostic, whose discovery opens up new possibilities in the field of 31P‐MR spectroscopy and imaging.
Measuring image distortions arising from age‐related macular degeneration: An Iterative Amsler Grid (IAG)
Authors: Ayhan Inci , Doyle Edward , Zanker Johannes 
Published: March 2022

AbstractMetamorphopsia, perceived as distortion of a shape, is experienced in age‐related macular degeneration (AMD): straight lines appear to be curved and wavy to AMD patients and some other retinal pathologies. Conventional clinical assessment largely relies on asking patients to identify irregularities in Amsler Grids ‐ a standardized set of equally spaced vertical and horizontal lines. Perceived distortions or gaps in the grid are a sign of macular pathology. Here, we developed an iterative Amsler Grid (IAG) procedure to obtain a quantifiable map of visual deformations. Horizontal and vertical line segments representing metamorphopsia are displayed on a computer screen. Line segments appearing distorted are adjusted by participants using the computer mouse to change their orientation in several iteratively such that they appear straight. Control participants are able to reliably correct deformations that simulate metamorphopsia while maintaining fixation in the center. In a pilot experiment, we attempted to obtain deformation maps from a small number of AMD patients. Whereas some patients with extensive scotomas found this procedure challenging, others were comfortable using the IAG and generating deformation maps corresponding to their subjective reports. This procedure may potentially be used to quantify local distortions and map them reliably in patients with early AMD.
Tyrosine phosphatase SHP2 exacerbates psoriasis‐like skin inflammation in mice via ERK5‐dependent NETosis
Authors: Ding Yan , Ouyang Zijun , Zhang Chenyang , Zhu Yuyu , Xu Qiang , Sun Haiyan , Qu Jiao , Sun Yang 
Published: March 2022

AbstractPsoriasis is a chronic inflammatory skin disease, often accompanied by increased infiltration of immune cells, especially neutrophils. However, the detailed mechanism of the neutrophil function in psoriasis progression remains unclear. Here, we found that both Src homology‐2 domain‐containing protein tyrosine phosphatase‐2 (SHP2) and neutrophils were highly correlated to developing psoriasis by single‐cell ribonucleic acid (RNA) sequencing and experiment verification. The deficiency of SHP2 in neutrophils significantly alleviated psoriasis‐like phenotype in an imiquimod‐induced murine model. Interestingly, high levels of neutrophil extracellular traps (NETs) were produced in the inflamed lesions of psoriatic patients. In addition, imiquimod‐induced psoriasis‐like symptoms were remarkably ameliorated in peptidyl arginine deiminase 4 (PAD4) knockout mice, which cannot form NETs. Mechanistically, RNA‐seq analysis revealed that SHP2 promoted the formation of NETs in neutrophils via the ERK5 pathway. Functionally, this mechanism resulted in the infiltration of pro‐inflammatory cytokines such as TNF‐α, IL‐1β, IL‐6, IL‐17A, and CXCL‐15, which enhances the inflammatory response in skin lesions and reinforces the cross‐talk between neutrophils and keratinocytes, ultimately aggravating psoriasis. Our findings uncover a role for SHP2 in NET release and subsequent cell death known as NETosis in the progression of psoriasis and suggest that SHP2 may be a promising therapeutic target for psoriasis.
Antiphospholipid‐Related Chorea: Two Case Reports and Role of Metabolic Imaging
Authors: Lerjefors Lisa , Andretta Silvia , Bonato Giulia , Mainardi Michele , Carecchio Miryam , Antonini Angelo 
Published: March 2022

ABSTRACTBackgroundAntiphospholipid syndrome (APS) is a complex acquired autoimmune disease with a wide clinical spectrum. Chorea is a rare neurological manifestation of APS.CasesWe report two elderly patients with APS‐related chorea in whom functional imaging (18F‐FDG positron emission tomography, FDG‐PET) supported the diagnosis and compare our findings with existing literature.Literature ReviewAmong 142 clinical cases of antiphospholipid‐related chorea found in literature, only 10 had undergone brain metabolic imaging. Striatal hypermetabolism was evident in all cases (6) that underwent FDG‐PET cerebral imaging. Cerebral perfusion single photon emission computed tomography (SPECT) was normal in two cases, while the other two presented with basal ganglia hypoperfusion.ConclusionsBrain FDG‐PET usually shows striatal hypometabolism in neurodegenerative types of chorea as opposed to striatal hypermetabolism observed in most cases of chorea from reversible etiologies, such as APS‐related chorea. When a patient's clinical presentation is not clearly suggestive of either a neurodegenerative or autoimmune chorea, and first‐line investigations are normal, FDG‐PET may help in the differential diagnosis, especially in the presence of striatal hypermetabolism. SPECT data are less numerous and show either normal scans or basal ganglia hypoperfusion.
High‐performance flexible humidity sensors for breath detection and non‐touch switches
Authors: Yao Xingye , Chen Lei , Luo Zewei , Ye Changqing , Liang Fang , Yang Tao , Liu Xingchi , Tian Xiyue , Bi Hengchang , Wang Chaolun , Cai Chunhua , Lyu Liangjian , Wu Xing 
Published: March 2022

AbstractFlexible humidity sensors have attracted much attention due to the promising applications in medical health monitoring. Up to now, the realization of such devices with ultrafast response/recovery and wide humidity range still remains a challenge. In this work, we report a new type of humidity sensor based on laser‐induced graphene (LIG) and graphene oxide (GO) with excellent performances. Graphene interdigital electrodes with good conductivity were prepared by the laser‐induced method. Then, the GO dispersion was drop‐coated on the interdigital electrode and heated to form a film as a sensing material. We have systematically studied the performances of the humidity sensor under different humidity levels. The experiment results reveal that the humidity sensor possesses high response, fast response/recovery behavior with 2 and 35 seconds, and wide humidity range from 11% RH to 97% RH. This proposed high‐performance humidity sensors could be applied in practical applications such as human breath monitoring under different states including slow breath, normal breath, fast breath, cough and rhinitis. In addition, the humidity sensors could also be used to monitor the approaching of fingertips, which makes the sensors be ideal non‐contact buttons of the elevator for stopping contacting spread of COVID‐19 viruses.
The effect of servant leadership on employees' extra‐role behaviors in NPOs: The role of work engagement
Authors: Aboramadan Mohammed , Hamid Zeeshan , Kundi Yasir Mansoor , El Hamalawi Eissa 
Published: March 2022

AbstractBuilding on the social exchange theory and the rule of reciprocity, this study examines the effect of servant leadership on employees' extra‐role behaviors (innovative work behavior, organizational citizenship behavior, and creativity) in the nonprofit organizations (NPOs) context. In this model, we examined work engagement as a mediator. Data were collected in two waves from 309 employees and complemented by their supervisors' evaluations. We analyzed the data using structural equation modeling and the Baron and Kenny method for mediation. The findings reveal that servant leadership exerts a positive influence on employees' extra‐role behaviors. Furthermore, work engagement plays a significant role as a mediator in the relationship between servant leadership and extra‐role behaviors. Finally, discussion, implications, and limitations are presented.
Evaluating opioid analgesic prescribing limits: A narrative review
Authors: Seitz Amy E. , Janiszewski Karen A. , Guy Gery P. , Tapscott Ryan T. , Einstein Emily B. , Meyer Tamra E. , Tierney Jessica , Staffa Judy , Jones Christopher M. , Compton Wilson M. 
Published: March 2022

AbstractPurposeIn response to the opioid crisis, opioid analgesic guidelines and prescribing limits have proliferated. The purpose of this narrative review is to examine evidence from studies evaluating the patient or public health impact of federal and state opioid analgesic prescribing guidelines and laws, describe gaps and challenges in current research, and highlight opportunities for improving future research.MethodsWe focused on evidence from a literature review covering 2013 through 2019. We identified 30 studies evaluating opioid analgesic thresholds based on federal policies and guidelines, state laws, and Medicaid state plans that attempt to influence the course of patient care at or when the limit is exceeded (e.g., prior authorization).ResultsMost studies evaluated changes in prescribing or dispensing patterns of opioid analgesics, largely finding decreases in prescribing after policy enactment. Fewer studies evaluated patient or public health outcomes beyond changes in prescribing and dispensing patterns; results were infrequently stratified by potentially important sociodemographic and clinical factors. No studies assessed the potential for adverse patient outcomes for which we have emerging evidence of harms.ConclusionsWe describe knowledge gaps and propose opportunities for future research to sufficiently assess the potential impact and unintended consequences of opioid analgesic prescribing laws, regulations, guidelines, and policies.
Antithrombotic Therapy by Regulating the ROS‐Mediated Thrombosis Microenvironment and Specific Nonpharmaceutical Thrombolysis Using Prussian Blue Nanodroplets
Authors: Zhang Wenli , Wang Junrui , Xie Zhuoyan , Zou Hongmi , Chen Qiaoqi , Xu Lian , Hu Liu , Fang Ni , Xu Jie , Zhou Jun , Liu Jia , Ran Haitao , Wang Zhigang , Zhang Yu , Guo Dajing 
Published: March 2022

AbstractIn thrombotic diseases, the effects of reactive oxygen species (ROS)‐mediated oxidative stress as a “perpetrator” in thrombosis must be resolved. Accordingly, an insufficient understanding of thrombus therapy prompted the authors to pursue a more comprehensive and efficient antithrombotic treatment strategy. A Prussian blue (PB)‐based nanodroplet system (PB‐PFP@PC) is designed using PB and perfluorinated pentane (PFP) in the core, and a targeting peptide (CREKA, Cys‐Arg‐Glu‐Lys‐Ala) is attached to poly(lactic‐coglycolic acid) (PLGA) as the delivery carrier shell. Upon near‐infrared (NIR) laser irradiation, PB and PFP jointly achieve an unprecedented dual strategy for drug‐free thrombolysis: photothermal therapy (PTT) combined with optical droplet vaporization (ODV). PB, a nanoenzyme, also regulates the vascular microenvironment via its antioxidant activity to continuously scavenge abnormally elevated ROS and correspondingly reduce inflammatory factors in the thrombus site. This study provides a demonstration of not only the potential of ODV in thrombus therapy but also the mechanism underlying PTT thrombolysis due to thermal ablation‐induced fibrin network structural damage. Moreover, PB catalyzes ROS to generate oxygen (O2), which combines with the ODV effect, enhancing the ultrasound signal. Thus, regulation of the thrombosis microenvironment combined with specific nonpharmaceutical thrombolysis by PB nanodroplets provides a more comprehensive and efficient antithrombotic therapeutic strategy.
Atomically Thin TaSe2 Film as a High‐Performance Substrate for Surface‐Enhanced Raman Scattering
Authors: Ge Yuancai , Wang Fei , Yang Ying , Xu Yi , Ye Ying , Cai Yu , Zhang Qingwen , Cai Shengying , Jiang DanFeng , Liu Xiaohu , Liedberg Bo , Mao Jian , Wang Yi 
Published: March 2022

AbstractAn atomically thin TaSe2 sample, approximately containing two to three layers of TaSe2 nanosheets with a diameter of 2.5 cm is prepared here for the first time and applied on the detection of various Raman‐active molecules. It achieves a limit of detection of 10−10 m for rhodamine 6G molecules. The excellent surface‐enhanced Raman scattering (SERS) performance and underlying mechanism of TaSe2 are revealed using spectrum analysis and density functional theory. The large adsorption energy and the abundance of filled electrons close to the Fermi level are found to play important roles in the chemical enhancement mechanism. Moreover, the TaSe2 film enables highly sensitive detection of bilirubin in serum and urine samples, highlighting the potential of using 2D SERS substrates for applications in clinical diagnosis, for example, in the diagnosis of jaundice caused by excess bilirubin in newborn children.
Post‐fire behavior of steel slag fine aggregate concrete
Authors: Zhuang Xin , Liang Yi , Ho Johnny Ching Ming , Wang Yu‐Hang , Lai Mianheng , Li Xuanyang , Xu Zhenhai , Xu Yuning 
Published: March 2022

AbstractUsing steel slag fine aggregate (SSFA) to replace river sand (RS) in making concrete offers a sustainable solution for mitigating the environmental issues owing to the large‐scale mining of RS and disposal of a large amount of steel slag. The mechanical behavior and chemical property of concrete made with SSFA at ambient temperature were investigated extensively. However, relatively few studies have been conducted to investigate the behavior of concrete with SSFA after exposure to elevated temperatures. To fill up this research gap, this paper studied the post‐fire behavior of five concrete mixes with SSFA replacing RS. The effect of SSFA replacement ratio by volume (0%, 25%, 50%, 75%, and 100%) on the heating temperature—time curve, color and appearance changes, weight loss, failure mode, and residual compressive strength of concrete under curing period of 28‐ and 91‐day, after exposure to 25 (ambient temperature), 400, 600, 800, and 1000°C was investigated. Besides, chemical composition at ambient and after exposure to elevated temperatures was analyzed with the aid of X‐ray diffraction. Test results showed that with SSFA partially or totally replacing RS, the heat insulation capability of concrete could be enhanced, especially at the replacement ratio of 75%. Moreover, concrete with RS replaced with SSFA presented larger or comparable residual strength after exposure to elevated temperatures from 600–800°C. Lastly, the design model by EC2 was adopted to predict the residual strength of concrete with and without SSFA. Comparing the design and measured residual strengths, it was concluded that EC2 was conservative.
Met–HER3 crosstalk supports proliferation via MPZL3 in MET-amplified cancer cells
Authors: Stern Yaakov E. , Al-Ghabkari Abdulhameed , Monast Anie , Fiset Benoit , Aboualizadeh Farzaneh , Yao Zhong , Stagljar Igor , Walsh Logan A. , Duhamel Stephanie , Park Morag 
Published: March 2022

AbstractReceptor tyrosine kinases (RTKs) are recognized as targets of precision medicine in human cancer upon their gene amplification or constitutive activation, resulting in increased downstream signal complexity including heterotypic crosstalk with other RTKs. The Met RTK exhibits such reciprocal crosstalk with several members of the human EGFR (HER) family of RTKs when amplified in cancer cells. We show that Met signaling converges on HER3–tyrosine phosphorylation across a panel of seven MET-amplified cancer cell lines and that HER3 is required for cancer cell expansion and oncogenic capacity in vitro and in vivo. Gene expression analysis of HER3-depleted cells identified MPZL3, encoding a single-pass transmembrane protein, as HER3-dependent effector in multiple MET-amplified cancer cell lines. MPZL3 interacts with HER3 and MPZL3 loss phenocopies HER3 loss in MET-amplified cells, while MPZL3 overexpression can partially rescue proliferation upon HER3 depletion. Together, these data support an oncogenic role for a HER3–MPZL3 axis in MET-amplified cancers.