bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Experimental Study on SiO2-ND Hybrid Nanofluid: Thermal
Conductivity, Viscosity, and Stability with New Forecast Models
Authors: Yalçın Gökberk , Öztuna Semiha , Dalkılıç Ahmet Selim , Nakkaew Santiphap , Wongwises Somchai 
Published: January 2022

Objective:
In the present investigation, thermal conductivity and viscosity properties of
water-based SiO2-ND hybrid nanofluid were measured, experimentally.

Methods:
Nanofluids were prepared by using a two-step method and with three different (0.5%,
0.75%, and 1%) concentrations. Every concentration had three different SiO2-ND mixtures (50%
SiO2 - 50% ND, 33% SiO2 - 66% ND, 66% SiO2 - 33% ND).

Results:
The most stable sample was measured as -33.4 mV. Measurements of viscosity and thermal
conductivity were done from 20 oC to 60 oC at every 10 oC. Thermal conductivity data were measured
by thermal conductivity analyzer and viscosity data were measured by tube viscometer. The
highest thermal conductivity enhancement was measured for 1% SiO2
0.33: ND 0.66 at 40 oC and the
highest relative dynamic viscosity was calculated as 4.19 for 1% SiO2
0.33: ND 0.66 at 40 oC. A comparison
table is also given to show the zeta potential values-concentration relations.

Conclusion:
Finally, two different correlations for predicting thermal conductivity and viscosity
were proposed for practical usage.
Cortex Mori Radicis Attenuates Streptozotocin-induced Diabetic Renal Injury
in Mice via Regulation of Transient Receptor Potential Canonical
Channel 6
Authors: Zhai Yi , Li Dan , Wang Zhigang , Shao Luyao , Yin Nina , Li Weihua 
Published: January 2022

Objective:
Cortex Mori Radicis (CMR) has been reported to possess antipyretic, anti-convulsant, anti-allergic, anti-inflammatory, and anti-diabetic effects. In this study, we aimed to investigate the effect of CMR on streptozotocin (STZ)-induced diabetic renal injury in mice and explore the underlying mechanism.

Methods:
Mice were gavaged with different doses of CMR for continuous 7 days. Then, STZ (50 mg/kg) was applied to induce renal injury associated with type 1 diabetes. Firstly, blood glucose levels and metabolic parameters were evaluated, including weight, food intake, and excrement. HE and PAS staining were performed to examine renal histological changes. Renal inflammation, fibro-sis, and oxidative stress were assayed by real-time PCR and ELISA, separately. Additionally, podo-cyte-related markers, such as nephrin and wilms' tumor-1 (WT-1), were detected by immunohisto-chemical staining and Western blot separately. Lastly, expression of transient receptor potential canonical channel 6 (TRPC6) and activation of MAPK signaling pathways were assayed.

Results:
CMR pretreatment significantly lowered the blood glucose levels, suppressed renal in-flammation, fibrosis, and oxidative stress, and relieved renal pathological injury, accompanying the inhibition of nephrin and WT-1 expression in STZ-induced diabetic mice. Moreover, CMR de-creased the expression of TRPC6 and suppressed the phosphorylation of ERK, but not P38 MAPK and JNK. Notably, the application of hyperforin, a specific activator of TRPC6, significantly abro-gated the hypoglycemic effect of CMR and reversed the suppression of CMR on TRPC6 expression and ERK activation in the diabetic mice.

Conclution:
Our findings indicated that CMR attenuated early renal injury in STZ-induced diabetic mice by inhibiting ERK signaling via regulation of TRPC6, suggesting that CMR can be considered as a promising candidate for the management of diabetes-related renal complications.
Assessment of Natural Language Processing Methods for Ascertaining the Expanded Disability Status Scale Score From the Electronic Health Records of Patients With Multiple Sclerosis: Algorithm Development and Validation Study
Authors: Yang Zhen , Pou-Prom Chloé , Jones Ashley , Banning Michaelia , Dai David , Mamdani Muhammad , Oh Jiwon , Antoniou Tony 
Published: January 2022

Background
The Expanded Disability Status Scale (EDSS) score is a widely used measure to monitor disability progression in people with multiple sclerosis (MS). However, extracting and deriving the EDSS score from unstructured electronic health records can be time-consuming.

Objective
We aimed to compare rule-based and deep learning natural language processing algorithms for detecting and predicting the total EDSS score and EDSS functional system subscores from the electronic health records of patients with MS.

Methods
We studied 17,452 electronic health records of 4906 MS patients followed at one of Canada’s largest MS clinics between June 2015 and July 2019. We randomly divided the records into training (80%) and test (20%) data sets, and compared the performance characteristics of 3 natural language processing models. First, we applied a rule-based approach, extracting the EDSS score from sentences containing the keyword “EDSS.” Next, we trained a convolutional neural network (CNN) model to predict the 19 half-step increments of the EDSS score. Finally, we used a combined rule-based–CNN model. For each approach, we determined the accuracy, precision, recall, and F-score compared with the reference standard, which was manually labeled EDSS scores in the clinic database.

Results
Overall, the combined keyword-CNN model demonstrated the best performance, with accuracy, precision, recall, and an F-score of 0.90, 0.83, 0.83, and 0.83 respectively. Respective figures for the rule-based and CNN models individually were 0.57, 0.91, 0.65, and 0.70, and 0.86, 0.70, 0.70, and 0.70. Because of missing data, the model performance for EDSS subscores was lower than that for the total EDSS score. Performance improved when considering notes with known values of the EDSS subscores.

Conclusions
A combined keyword-CNN natural language processing model can extract and accurately predict EDSS scores from patient records. This approach can be automated for efficient information extraction in clinical and research settings.
Development and Evaluation of the Usefulness, Usability, and Feasibility of iNNOV Breast Cancer: Mixed Methods Study
Authors: Mendes-Santos Cristina , Nunes Francisco , Weiderpass Elisabete , Santana Rui , Andersson Gerhard 
Published: January 2022

Background
Despite the efficacy of psychosocial interventions in minimizing psychosocial morbidity in breast cancer survivors (BCSs), intervention delivery across survivorship is limited by physical, organizational, and attitudinal barriers, which contribute to a mental health care treatment gap in cancer settings.

Objective
The aim of this study is to develop iNNOV Breast Cancer (iNNOVBC), a guided, internet-delivered, individually tailored, acceptance and commitment therapy–influenced cognitive behavioral intervention program aiming to treat mild to moderate anxiety and depression in BCSs as well as to improve fatigue, insomnia, sexual dysfunction, and health-related quality of life in this group. This study also aims to evaluate the usefulness, usability, and preliminary feasibility of iNNOVBC.

Methods
iNNOVBC was developed using a user-centered design approach involving its primary and secondary end users, that is, BCSs (11/24, 46%) and mental health professionals (13/24, 54%). We used mixed methods, namely in-depth semistructured interviews, laboratory-based usability tests, short-term field trials, and surveys, to assess iNNOVBC’s usefulness, usability, and preliminary feasibility among these target users. Descriptive statistics were used to characterize the study sample, evaluate performance data, and assess survey responses. Qualitative data were recorded, transcribed verbatim, and thematically analyzed.

Results
Overall, participants considered iNNOVBC highly useful, with most participants reporting on the pertinence of its scope, the digital format, the relevant content, and the appropriate features. However, various usability issues were identified, and participants suggested that the program should be refined by simplifying navigation paths, using a more dynamic color scheme, including more icons and images, displaying information in different formats and versions, and developing smartphone and tablet versions. In addition, participants suggested that tables should be converted into plain textboxes and data visualization dashboards should be included to facilitate the tracking of progress. The possibility of using iNNOVBC in a flexible manner, tailoring it according to BCSs’ changing needs and along the cancer care continuum, was another suggestion that was identified.

Conclusions
The study results suggest that iNNOVBC is considered useful by both BCSs and mental health professionals, configuring a promising point-of-need solution to bridge the psychological supportive care gap experienced by BCSs across the survivorship trajectory. We believe that our results may be applicable to other similar programs. However, to fulfill their full supportive role, such programs should be comprehensive, highly usable, and tailorable and must adopt a flexible yet integrated structure capable of evolving in accordance with survivors’ changing needs and the cancer continuum.
Refinement of a Parent–Child Shared Asthma Management Mobile Health App: Human-Centered Design Study
Authors: Sonney Jennifer , Cho Emily E , Zheng Qiming , Kientz Julie A 
Published: January 2022

Background
The school-age years, approximately ages 7 through 11, represent a natural transition when children begin assuming some responsibility for their asthma management. Previously, we designed a theoretically derived, tailored parent–child shared asthma management mobile health app prototype, Improving Asthma Care Together (IMPACT).

Objective
The purpose of this study was to use human-centered design (HCD) to iteratively refine IMPACT to optimize user experience and incorporate evidence-based longitudinal engagement strategies.

Methods
This study used a mixed methods design from December 2019 to April 2021. Our app refinement used the HCD process of research, ideation, design, evaluation, and implementation, including 6 cycles of design and evaluation. The design and evaluation cycles focused on core app functionality, child engagement, and overall refinement. Evaluation with parent–child dyads entailed in-person and remote concept testing and usability testing sessions, after which rapid cycle thematic analyses identified key insights that informed future design refinement.

Results
Twelve parent–child dyads enrolled in at least one round of this study. Eight of the 12 child participants were male with a mean age of 9.9 (SD 1.6) years and all parent participants were female. Throughout evaluation cycles, dyads selected preferred app layouts, gamification concepts, and overall features with a final design prototype emerging for full-scale development and implementation.

Conclusions
A theoretically derived, evidence-based shared asthma management app was co-designed with end users to address real-world pain points and priorities. An 8-week pilot study testing app feasibility, acceptability, and preliminary efficacy is forthcoming.
Longitudinal Relationships Between Depressive Symptom Severity and Phone-Measured Mobility: Dynamic Structural Equation Modeling Study
Authors: Zhang Yuezhou , Folarin Amos A , Sun Shaoxiong , Cummins Nicholas , Vairavan Srinivasan , Bendayan Rebecca , Ranjan Yatharth , Rashid Zulqarnain , Conde Pauline , Stewart Callum , Laiou Petroula , Sankesara Heet , Matcham Faith , White Katie M , Oetzmann Carolin , Ivan Alina , Lamers Femke , Siddi Sara , Vilella Elisabet , Simblett Sara , Rintala Aki , Bruce Stuart , Mohr David C , Myin-Germeys Inez , Wykes Til , Haro Josep Maria , Penninx Brenda WJH , Narayan Vaibhav A , Annas Peter , Hotopf Matthew , Dobson Richard JB ,   RADAR-CNS consortium
Published: January 2022

Background
The mobility of an individual measured by phone-collected location data has been found to be associated with depression; however, the longitudinal relationships (the temporal direction of relationships) between depressive symptom severity and phone-measured mobility have yet to be fully explored.

Objective
We aimed to explore the relationships and the direction of the relationships between depressive symptom severity and phone-measured mobility over time.

Methods
Data used in this paper came from a major EU program, called the Remote Assessment of Disease and Relapse–Major Depressive Disorder, which was conducted in 3 European countries. Depressive symptom severity was measured with the 8-item Patient Health Questionnaire (PHQ-8) through mobile phones every 2 weeks. Participants’ location data were recorded by GPS and network sensors in mobile phones every 10 minutes, and 11 mobility features were extracted from location data for the 2 weeks prior to the PHQ-8 assessment. Dynamic structural equation modeling was used to explore the longitudinal relationships between depressive symptom severity and phone-measured mobility.

Results
This study included 2341 PHQ-8 records and corresponding phone-collected location data from 290 participants (age: median 50.0 IQR 34.0, 59.0) years; of whom 215 (74.1%) were female, and 149 (51.4%) were employed. Significant negative correlations were found between depressive symptom severity and phone-measured mobility, and these correlations were more significant at the within-individual level than the between-individual level. For the direction of relationships over time, Homestay (time at home) (φ=0.09, P=.01), Location Entropy (time distribution on different locations) (φ=−0.04, P=.02), and Residential Location Count (reflecting traveling) (φ=0.05, P=.02) were significantly correlated with the subsequent changes in the PHQ-8 score, while changes in the PHQ-8 score significantly affected (φ=−0.07, P<.001) the subsequent periodicity of mobility.

Conclusions
Several phone-derived mobility features have the potential to predict future depression, which may provide support for future clinical applications, relapse prevention, and remote mental health monitoring practices in real-world settings.
Intervenções educativas em medicina transfusional: uma revisão integrativa
Authors: Siqueira Vitória de Souza , Neto Silvestre Savino 
Published: January 2022

A falta de conhecimento por parte dos profissionais de saúde pode levar a um aumento do risco de mortalidade e morbidade associada à transfusão de sangue. Os currículos oferecem pouco espaço para esse tema. O presente estudo objetiva analisar as intervenções educativas em medicina transfusional. Para isso, consultaram-se bases eletrônicas de dados, a partir dos descritores: Transfusão, Medicina Transfusional e Educação em Saúde. Várias são as opções propostas como intervenções educacionais. É necessário que estas se estabelecem na forma de educação continuada e que um processo avaliativo rigoroso validado seja aplicado.
Palavras-chave: Transfusão, Medicina Transfusional, Educação em Saúde
Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABAA receptors by two distinct mechanisms
Authors: Bampali Konstantina , Koniuszewski Filip , Silva Luca , Rehman Sabah , Vogel Florian , Seidel Thomas , Scholze Petra , Zirpel Florian , Garon Arthur , Langer Thierry , Willeit Matthäus , Ernst Margot 
Published: January 2022

Background and Purpose: Many psychotherapeutic drugs, including
clozapine, display polypharmacology and act on GABA
receptors. Patients with schizophrenia show alterations in function,
structure and molecular composition of the hippocampus, and a recent
study demonstrated aberrant levels of hippocampal a5 subunit-containing
GABA receptors. The purpose of this study is to
investigate tricyclic compounds in a5 subunit-containing receptor
subtypes.
Experimental Approach: Functional studies of effects by seven
antipsychotic and antidepressant medications were performed in several
GABA receptor subtypes by two‐electrode voltage‐clamp
electrophysiology using Xenopus laevis oocytes. Computational
structural analysis was employed to design mutated constructs of the a5
subunit, probing a novel binding site. Radioligand displacement data
complemented the functional and mutational findings.
Key Results: We show that the antipsychotic drugs clozapine and
chlorpromazine exert functional inhibition on multiple
GABA receptor subtypes, including a5-containing ones.
Based on a chlorpromazine binding site observed in a GABA-gated
bacterial homologue, we identified a novel site in a5
GABA receptor subunits and demonstrate differential
usage of this and the orthosteric sites by these ligands.
Conclusion and Implications: Despite high molecular and
functional similarities among the tested ligands, they reduce GABA
currents by differential usage of allosteric and orthosteric sites. The
CPZ site we describe here is a new potential target for optimizing
antipsychotic medications with beneficial polypharmacology. Further
studies in defined subtypes are needed to substantiate mechanistic links
between the therapeutic effects of clozapine and its action on certain
GABA receptor subtypes.
MEDIA KATALOG DIGITAL UNTUK PEMBELAJARAN SEJARAH DI MASA PANDEMI COVID-19
Authors: Ramadhan Fahmi Nur , Sunardi Sunardi , Musadad Akhmad Arif 
Published: January 2022

Abstract
Various new problems emerged after history learning which is currently carried out online due to the Covid-19 virus pandemic. Thes new problems make the promblems in history learning more diverse after conventional history learning also experiences many problems. Various problems that arise in online history learning such as students who are easily bored and tired, student who increasingly do not understand the material presented, students who are inceasingly not interested in online history learning, students do not always pay attention and are not easy to monitor after learning online history. The purpose of this research is to overcome various problems that occur due to online history learning through the use of the Digital History Catalog learning media. This study uses a research method in the form of descriptive qualitative research. The result showed that uses of appropriate, innovative, interactive learning media and being able to adapt to online learning was needed both by students and by the teachers themselves. Media such as the Digital History Catalog can overcome the problems that occur due to online history learning. Digital History Catalog Media can adjust the material to be delivered according to those listed in the KI and KD of history learning.

Keywords: History Learning, Covid-19 Pandemic, History Digital Catalog.

Abstrak
Berbagai permasalahan baru muncul setelah pembelajaran sejarah yang saat ini dilakukan secara online akibat terjadinya pandemi virus Covid-19. Masalah-masalah baru tersebut membuat masalah dalam pembelajaran sejarah semakin beragam setelah pembelajaran sejarah secara konvensional pun mengalami banyak permasalahan. Berbagai masalah yang muncul dalam pembelajaran sejarah online seperti misalnya siswa yang mudah cepat bosan dan lelah, siswa yang semakin tidak paham tentang materi yang disampaikan, siswa yang tidak tertarik dengan pembelajaran sejarah online, siswa tidak selalu memperhatikan dan tidak mudah untuk dipantau setelah dilakukannya pembelajaran sejarah online. Tujuan dari penelitian yang dilakukan ini ialah untuk mengatasi berbagai permasalah yang terjadi akibat pembelajaran sejarah online melalui sebuah penggunaan media pembelajaran Katalog Digital Sejarah. Penelitian ini menggunakan metode penelitian berupa penelitian kualitatif deskriptif. Hasil penelitian menunjukkan bahwa penggunaan media pembelajaran yang tepat, inovatif, dan interakitf serta mampu menyesuaikan dengan pembelajaran online sangat dibutuhkan baik oleh siswa maupun oleh guru sendiri. Media seperti Katalog Digital Sejarah dapat mengatasi permasalahan-permasalahan yang terjadi akibat pembelajaran sejarah online. Media Katalog Digital Sejarah dapat menyesuaikan materi yang akan disampaikan sesuai dengan yang tercantum dalam KI dan KD pembelajaran sejarah.

Kata Kunci: Pembelajaran Sejarah; Pandemi Covid-19; Katalog Digital Sejarah
Utilizing smartphone-based electrocardiography and thoracic radiography to evaluate cardiac function and morphology in geriatric Sika deer (Cervus nippon)
Authors: Gonzalez-Jassi Hugo A. , LeBlanc Nicole , Alcantar Benjamin E. , Garces Torres Rodrigo S. 
Published: January 2022

Abstract

OBJECTIVE
To describe qualitative and quantitative cardiothoracic values in geriatric Sika deer (Cervus nippon) using digital radiography, 6-lead ECG (sECG), and smartphone-based ECG (aECG).

ANIMALS
10 healthy geriatric Sika deer (9 females and 1 male).

PROCEDURES
Deer were chemically immobilized, thoracic radiographs were obtained, and inhalant anesthesia was initiated. An sECG and aECG were simultaneously recorded for each animal using the same ECG specifications. Results were compared between devices.

RESULTS
Radiographically, no deer had any cardiopulmonary abnormalities. Median (range) values for the most important cardiac measurements were 170 (153–193) mm for cardiac height, 135 (122–146) mm for cardiac width, 9 (8–9) for vertebral heart score, and 99 (69–124) mm for cardiosternal contact. All deer had a normal sinus rhythm with no pathological arrhythmias noted. A significant difference between sECG and aECG was identified for minimum heart rate (49 vs 51 beats/min, respectively), P wave duration (0.05 vs 0.03 seconds), P wave amplitude (0.28 vs 0.10 mV), PR interval (0.15 vs 0.12 seconds), and QT interval (0.39 vs 0.30 seconds).

CLINICAL RELEVANCE
Thoracic radiographs were suitable to evaluate basic cardiothoracic morphology in Sika deer. The aECG was useful for assessing heart rate and rhythm but, compared with sECG, proved no substitute for evaluating duration and amplitude of ECG waveforms.
Acellular fish skin grafts for the management of wounds in dogs and cats: 17 cases (2019–2021)
Authors: Mauer Elise S. , Maxwell Elizabeth A. , Cocca Christina J. , Ganjei Justin , Spector Daniel 
Published: January 2022

Abstract

OBJECTIVE
To report the clinical outcomes of the use of acellular fish skin grafts (FSGs) for the management of complex soft tissue wounds of various etiologies in dogs and cats.

ANIMALS
13 dogs and 4 cats with complex wounds treated with FSGs between February 2019 and March 2021.

PROCEDURES
Medical records were reviewed for information regarding cause, location, size of the wound, management techniques, complications, and clinical outcomes.

RESULTS
In dogs, the number of FSG applications ranged from 1 to 4 (median, 2 graft applications). The time between each application ranged from 4 to 21 days (median, 9.5 days). Time to application of the first FSG ranged from 9 to 210 days (median, 19 days). Wounds closed by second-intention healing following the first fish skin application between 26 and 145 days (median, 71 days; n = 12). In cats, 1 or 2 FSGs were used, and the wounds of 3 of 4 cats healed completely by secondary intention. The wounds of 1 dog and 1 cat did not heal. There were no adverse events attributed to the use of the FSGs.

CLINICAL RELEVANCE
For dogs and cats of the present study, complete healing of most wounds occurred with the use of FSGs, the application of which did not require special training, instruments, or bandage materials.