bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovations in suicide prevention research (INSPIRE): a protocol for a population-based case–control study
Authors: Ranapurwala Shabbar I , Miller Vanessa E , Carey Timothy S , Gaynes Bradley N , Keil Alexander P , Fitch Kate Vinita , Swilley-Martinez Monica E , Kavee Andrew L , Cooper Toska , Dorris Samantha , Goldston David B , Peiper Lewis J , Pence Brian W 
Published: June 2022

BackgroundSuicide deaths have been increasing for the past 20 years in the USA resulting in 45 979 deaths in 2020, a 29% increase since 1999. Lack of data linkage between entities with potential to implement large suicide prevention initiatives (health insurers, health institutions and corrections) is a barrier to developing an integrated framework for suicide prevention.ObjectivesData linkage between death records and several large administrative datasets to (1) estimate associations between risk factors and suicide outcomes, (2) develop predictive algorithms and (3) establish long-term data linkage workflow to ensure ongoing suicide surveillance.MethodsWe will combine six data sources from North Carolina, the 10th most populous state in the USA, from 2006 onward, including death certificate records, violent deaths reporting system, large private health insurance claims data, Medicaid claims data, University of North Carolina electronic health records and data on justice involved individuals released from incarceration. We will determine the incidence of death from suicide, suicide attempts and ideation in the four subpopulations to establish benchmarks. We will use a nested case–control design with incidence density-matched population-based controls to (1) identify short-term and long-term risk factors associated with suicide attempts and mortality and (2) develop machine learning-based predictive algorithms to identify individuals at risk of suicide deaths.DiscussionWe will address gaps from prior studies by establishing an in-depth linked suicide surveillance system integrating multiple large, comprehensive databases that permit establishment of benchmarks, identification of predictors, evaluation of prevention efforts and establishment of long-term surveillance workflow protocols.
Update regarding the role of PD-L1 in oncocytic thyroid lesions on cytological samples
Authors: Dell'Aquila Marco , Tralongo Pietro , Granitto Alessia , Martini Maurizio , Capodimonti Sara , Curatolo Mariangela , Fiorentino Vincenzo , Pontecorvi Alfredo , Fadda Guido , Lombardi Celestino Pio , Raffaelli Maco , Pantanowitz Liron , Larocca Luigi Maria , Rossi Esther Diana 
Published: June 2022

AimsSeveral papers have shown that programmed death-ligand 1 (PD-L1) expression is a relevant predictive biomarker in anti-PD-L1 cancer immunotherapy. While its role in several human cancers is correlated with poor prognosis and resistance to anticancer therapies, in thyroid cancers the role of PD-L1 remains questionable. Few articles have studied PD-L1 in thyroid fine-needle aspiration cytology (FNAC), demonstrating a possible correlation with papillary thyroid carcinoma. However, its role in oncocytic thyroid lesions remains controversial. We accordingly examine the performance of PD-L1 immunostaining in liquid based cytology (LBC) from oncocytic lesions.MethodsFrom January 2019 to March 2021, 114 thyroid lesions diagnosed by FNAC from lesions with a predominant oncocytic component, were enrolled for evaluation by PD-L1 immunostaining on both LBC and corresponding histology samples.ResultsThe FNAC cohort included 51 benign (B, negative controls), 4 atypia of undetermined significance/follicular lesions of undetermined significance (AUS/FLUS), 57 follicular lesions (follicular neoplasm/suspicious for FN, FN/SFN) and 2 suspicious for malignancy (SFM) cases. Fifty-four cases (11B, 2 AUS/FLUS, 39 FN/SFN and 2 SFM) had histological follow-up including: 1B case resulted as a hyperplastic oxyphilic nodule in Hashimoto thyroiditis (HT), 10B as goitre, 2 AUS/FLUS cases as oncocytic adenomas (OAs); 39 FN/SFN included 27 OAs, 4 FA and 8 oncocytic follicular carcinoma (OFC). The two SFM cases were diagnosed on histopathology as OAs. Increased plasma membrane and cytoplasmic PD-L1 expression were found in 47 cases of the LBC cases (41.2%). Among the histological series, 67.3% of OAs and 75% of OFC had PD-L1 expression, while negative PD-L1 was found in hyperplastic oncocytic cells in HT. A positivity in more than 30% of the neoplastic cells was found in 72.9% of the cases including six OFC.ConclusionsThese data suggest that PD-L1 expression is expressed in oncocytic thyroid lesions. While weak PD-L1 expression failed to discriminate benign from malignant lesions, OFC demonstrated more intense cytoplasmic and membranous expression.
One-step genotyping of α-thalassaemia by multiplex symmetric PCR melting curve
Authors: Qin Jiachun , He Jun , Li Yang , Liu Nansong , Tao Fangchao , Zhang Pengyi , Guo Weilin , Qin Qiongzhen , Zhou Wanjun 
Published: June 2022

AimsAlpha-thalassaemia is one of the most common monogenic disorders worldwide. Due to high guanine-cytosine (GC) content and high mutation diversity in α-globin gene cluster, deletional and non-deletional mutations were usually separately detected with different methods. The aim of this study was to develop a novel one-step method for α-thalassaemia genotyping.MethodsA multiplex symmetric PCR melting curve strategy was designed for one-step α-thalassaemia genotyping. Based on this strategy, a novel method was developed to simultaneously detect four common deletional (-α3.7,-α4.2,_ _SEA,--THAI) and five common non-deletional (αCD30(-GAG)α,αCD31(G>A)α,αWSα, αQSα, αCSα) α-thalassaemia mutations in a closed-tube reaction. This method was also evaluated by double-blind detection of 235 genotype-known samples and 1630 clinical samples.ResultsAll nine α-thalassaemia mutations could be accurately identified by this novel method within 3 hours. The evaluation results also showed a 100% concordance with comparison methods.ConclusionsThis method is rapid, accurate, low-cost and easy to operate, which can be used for molecular screening and genetic diagnosis of α-thalassaemia in clinical practice. The multiplex symmetric PCR melting curve strategy designed in this study can also provide an effective approach to the method development for high GC content templates and multiple mutations.
Traversable Casimir wormholes inDdimensions
Authors: Oliveira P. H. F. , Alencar G. , Jardim I. C. , Landim R. R. 
Published: June 2022

Wormholes (WHs) require negative energy, and therefore an exotic matter source. Since Casimir energy is negative, it has been speculated as a good candidate to source those objects a long time ago. However, only very recently, a full solution for [Formula: see text] has been found by [R. Garattini, Eur. Phys. J. C 79, 951 (2019), doi:10.1140/epjc/s10052-019-7468-y] thus the Casimir energy can be a source of traversable WHs. Soon later [G. Alencar, V. B. Bezerra and C. R. Muniz, arXiv:2104.13952 [gr-qc]] have shown, that this is not true in [Formula: see text]. In this paper, we show that Casimir energy can be a source of the Morris–Thorne WH for all spacetime with [Formula: see text]. Finally, we add the cosmological constant and find that for [Formula: see text] Casimir WHs are possible, however, the space must always be AdS. For [Formula: see text], we show that the cosmological constant invert the signal with increasing throat size.
Model Comparison of the Transverse Momentum Spectra of Charged Hadrons Produced in
P
b
P
b
Collision at

s

N
N

=
5.02
TeV
Authors: Gupta Rohit , Jena Satyajit 
Published: June 2022

Transverse momentum,

p

T

, spectra are of prime importance in order to extract crucial information about the evolution dynamics of the system of particles produced in the collider experiments. In this work, the transverse momentum spectra of charged hadrons produced in

P
b
P
b

collision at

5.02

TeV have been analyzed using different distribution functions in order to gain strong insight into the information that can be extracted from the spectra. We have also discussed the applicability of the unified statistical framework on the spectra of charged hadron at

5.02

TeV
Simulation Analysis and Experimental Testing of Spin-Magnetic Piezoelectric Generators
Authors: Tian Xiaochao , Wang Hu , Lin Jiaying , Wang Zhicong , Liu Jinlong , Li Shenfang , Hou Jun , Zhu Jinzhi , Lei Qing 
Published: June 2022

In order to investigate the optimal power generation performance of piezoelectric materials, a spin-magnetic piezoelectric generator was designed and the relationship between output voltage and speed and external force was derived through theoretical analysis. The maximum deformation and resonant frequency of the piezoelectric oscillator under magnetic drive are derived from simulation analysis. Finally, the relationship between output voltage and magnet size, distance between two magnets, and speed was tested experimentally, and the experimental data agreed with the theoretical analysis. The results show that when the speed is 312 r/min, magnet pitch is 12 mm, and magnet size is 10 mm

∗

35 mm

∗

4, the maximum output voltage is 54 V. This can meet the power supply needs of micro and small electronic products.
Altered Cerebral Microstructure in Adults With Atrial Septal Defect and Ventricular Septal Defect Repaired in Childhood
Authors: Asschenfeldt Benjamin , Evald Lars , Salvig Camilla , Heiberg Johan , Østergaard Leif , Eskildsen Simon Fristed , Hjortdal Vibeke Elisabeth 
Published: June 2022

Background
Delayed brain development, brain injury, and neurodevelopmental disabilities are commonly observed in infants operated for complex congenital heart defect. Our previous findings of poorer neurodevelopmental outcomes in individuals operated for simple congenital heart defects calls for further etiological clarification. Hence, we examined the microstructural tissue composition in cerebral cortex and subcortical structures in comparison to healthy controls and whether differences were associated with neurodevelopmental outcomes.

Methods and Results

Adults (n=62) who underwent surgical closure of an atrial septal defect (n=33) or a ventricular septal defect (n=29) in childhood and a group of healthy, matched controls (n=38) were enrolled. Brain diffusional kurtosis imaging and neuropsychological assessment were performed. Cortical and subcortical tissue microstructure were assessed using mean kurtosis tensor and mean diffusivity and compared between groups and tested for associations with neuropsychological outcomes. Alterations in microstructural tissue composition were found in the parietal, temporal, and occipital lobes in the congenital heart defects, with distinct mean kurtosis tensor cluster‐specific changes in the right visual cortex (pericalcarine gyrus,
P
=0.002; occipital part of fusiform and lingual gyri,
P
=0.019). Altered microstructural tissue composition in the subcortical structures was uncovered in atrial septal defects but not in ventricular septal defects. Associations were found between altered cerebral microstructure and social recognition and executive function.

Conclusions
Children operated for simple congenital heart defects demonstrated altered microstructural tissue composition in the cerebral cortex and subcortical structures during adulthood when compared with healthy peers. Alterations in cerebral microstructural tissue composition were associated with poorer neuropsychological performance.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03871881.
Sex‐Based Differences in Outcomes Following Peripheral Artery Revascularization: Insights From VOYAGER PAD
Authors: Hess Connie N. , Baumgartner Iris , Anand Sonia S. , Nehler Mark R. , Patel Manesh R. , Debus E. Sebastian , Szarek Michael , Capell Warren , Muehlhofer Eva , Berkowitz Scott D. , Haskell Lloyd P. , Bauersachs Rupert M. , Bonaca Marc P. , Hsia Judith 
Published: June 2022

Background
Despite high female prevalence of peripheral artery disease (PAD), little is known about sex‐based outcomes after lower extremity revascularization (LER) for symptomatic PAD. The effects of rivaroxaban according to sex following LER have not been fully reported.

Methods and Results

In VOYAGER PAD (Vascular Outcomes Study of ASA [acetylsalicylic acid] Along with Rivaroxaban in Endovascular or Surgical Limb Revascularization for Peripheral Artery Disease), low‐dose rivaroxaban versus placebo on a background of aspirin reduced the composite primary efficacy outcome of cardiovascular and limb events in patients with PAD undergoing LER. Unplanned index limb revascularization was prespecified and prospectively ascertained. The primary safety outcome was Thrombolysis in Myocardial Infarction major bleeding. Analyses of outcomes and treatment effects by sex were performed using Cox proportional hazards models. Among 6564 randomly assigned patients followed for a median of 28 months, 1704 (26.0%) were women. Among patients administered placebo, women were at similar risk for the primary efficacy outcome (hazard ratio [HR], 0.90; [95% CI, 0.74–1.09];
P
=0.29) as men, while female sex was associated with a trend toward higher risk of unplanned index limb revascularization (HR, 1.18; [95% CI, 1.00–1.40];
P
=0.0499). Irrespective of sex, effects of rivaroxaban were consistent for the primary efficacy outcome (
P
‐interaction=0.22), unplanned index limb revascularization (
P
‐interaction=0.64), and bleeding (
P
‐interaction=0.61). Women were more likely than men to discontinue study treatment (HR, 1.13; [95% CI, 1.03–1.25];
P
=0.0099).

Conclusions
Among >1700 women with PAD undergoing LER, women and men were at similar risk for the primary outcome, but a trend for greater risk of unplanned index limb revascularization among women was observed. Effects of rivaroxaban were consistent by sex, though women more often discontinued treatment. Better understanding of sex‐based outcomes and treatment adherence following LER is needed.

Registration

URL:
http://clinicaltrials.gov
; Unique identifier: NCT02504216.
Transcatheter Aortic Valve Implantation With and Without Resheathing and Repositioning: A Systematic Review and Meta‐analysis
Authors: Moroni Francesco , Azzalini Lorenzo , Sondergaard Lars , Attizzani Guilherme F. , García Santiago , Jneid Hani , Mamas Mamas A. , Bagur Rodrigo 
Published: June 2022

Background
There is a concern that resheathing/repositioning of transcatheter heart valves during transcatheter aortic valve implantation (TAVI) may lead to an increased risk of periprocedural complications. We aimed to evaluate the short‐ and long‐term impact on clinical outcomes of resheathing for repositioning of transcatheter heart valves during TAVI procedures.

Methods and Results

We conducted a systematic search of Embase, MEDLINE, and Cochrane Central Register of Controlled Trials databases to identify studies comparing outcomes between patients requiring resheathing/repositioning during TAVI and those who did not. Random‐effects meta‐analyses were used to estimate the association of resheathing compared with no resheathing with clinical outcomes after TAVI. Seven studies including 4501 participants (pooled mean age, 80.9±7.4 years; 54% women; and 1374 [30.5%] patients requiring resheathing/repositioning) were included in this study. No significant differences between the 2 groups were identified with regards to safety: 30‐day mortality (n=3125; odds ratio [OR], 0.74 [95% confidence interval [CI], 0.41–1.33];
I
2
=0%), stroke (n=4121; OR, 1.09 [95% CI, 0.74–1.62];
I
2
=0%), coronary obstruction (n=3000; OR, 2.35 [95% CI, 0.17–33.47];
I
2
=75%), major vascular complications (n=3125; OR, 0.92 [95% CI, 0.66–1.33];
I
2
=0%), major bleeding (n=3125; OR, 1.13 [95% CI, 0.94–2.01];
I
2
=39%), acute kidney injury (n=3495; OR, 1.30 [95% CI, 0.64–2.62];
I
2
=44%), and efficacy outcomes: device success (n=1196; OR, 0.77 [95% CI, 0.51–1.14];
I
2
=0%), need for a second valve (n=3170; OR, 2.86 [95% CI, 0.96–8.48];
I
2
=62%), significant (moderate or higher) paravalvular leak (n=1151; OR, 1.53 [95% CI, 0.83–2.80];
I
2
=0%), and permanent pacemaker implantation (n=1908; OR, 1.04 [95% CI, 0.68–1.57];
I
2
=58%). One‐year mortality was similar between groups (n=1972; OR, 1.00 [95% CI, 0.68–1.47];
I
2
=0%).

Conclusions
Resheathing of transcatheter heart valves during TAVI is associated with similar periprocedural risk compared with no resheathing in several patient‐important outcomes. These data support the safety of current self‐expanding transcatheter heart valves with resheathing features.

Registration

URL:
https://www.crd.york.ac.uk/prospero/
; Unique identifier: CRD42021273715.
Prediction of Prehospital Change of the Cardiac Rhythm From Nonshockable to Shockable in Out‐of‐Hospital Patients With Cardiac Arrest: A Post Hoc Analysis of a Nationwide, Multicenter, Prospective Registry
Authors: Emoto Ryo , Nishikimi Mitsuaki , Shoaib Muhammad , Hayashida Kei , Nishida Kazuki , Kikutani Kazuya , Ohshimo Shinichiro , Matsui Shigeyuki , Shime Nobuaki , Iwami Taku 
Published: June 2022

Background
Predicting a spontaneous rhythm change from nonshockable to shockable before hospital arrival in patients with out‐of‐hospital cardiac arrest can help emergency medical services develop better strategies for prehospital treatment. The aim of this study was to identify predictors of spontaneous rhythm change before hospital arrival in patients with out‐of‐hospital cardiac arrest and develop a predictive scoring system.

Methods and Results
We retrospectively reviewed data of eligible patients with out‐of‐hospital cardiac arrest with an initial nonshockable rhythm registered in a nationwide registry between June 2014 and December 2017. We performed a multivariable analysis using a Cox proportional hazards model to identify predictors of a spontaneous rhythm change, and a ridge regression model for predicting it. The data of 25 804 patients were analyzed (derivation cohort, n=17 743; validation cohort, n=8061). The rhythm change event rate was 4.1% (724/17 743) in the derivation cohort, and 4.0% (326/8061) in the validation cohorts. Age, sex, presence of a witness, initial rhythm, chest compression by a bystander, shock with an automated external defibrillator by a bystander, and cause of the cardiac arrest were all found to be independently associated with spontaneous rhythm change before hospital arrival. Based on this finding, we developed and validated the Rhythm Change Before Hospital Arrival for Nonshockable score. The Harrell’s concordance index values of the score were 0.71 and 0.67 in the internal and external validations, respectively.

Conclusions
Seven factors were identified as predictors of a spontaneous rhythm change from nonshockable to shockable before hospital arrival. We developed and validated a score to predict rhythm change before hospital arrival.
Between Visual Scenes and Beautiful Lives: A Conversation with Saidiya Hartman
Authors: Copeland Huey , Dickerman Leah , Lee Pamela M. 
Published: June 2022

Abstract
This wide-ranging conversation with Black cultural theorist Saidiya Hartman—occasioned by the twenty-fifth anniversary of her groundbreaking first book, Scenes of Subjection, to be republished this year in an edition by Norton—explores the author's shifting approaches to the visual over time, the limitations and potentialities of the archive for its discontents, and the models she has both turned to and herself invented—most notably the concept of “critical fabulation”—in the ongoing attempt to find ethical modes of engaging African/Diasporic life, thought, and form in an anti-Black world.
Lawrence Weiner's Materialism
Authors: Stark Trevor 
Published: June 2022

Abstract
From the 1960s until his death in 2021, Lawrence Weiner developed an art practice operating in language, which he described as being that of a “materialist.” This paper examines the scope of Weiner's career to determine what he could mean by that term—to derive the specific characteristics of his linguistic materialism. Differentiating his work from existing materialist paradigms in poetics and linguistics, this paper argues that the matter of language for Weiner was not reducible to the visual character of the signifier or to the physicality of the referent. Rather than attempt to define language as such, Weiner's materialism set into motion the infinite social uses of words within the “stream of life.”
On Dan Graham: Memories in Alteration
Authors: De Bruyn Eric C. H. 
Published: June 2022

Abstract
Written in memory of Dan Graham, “Memories in Alteration” considers the important legacy of the artist's work, focusing on the topological and paralogical devices that characterize his discursive and artistic practice. The text adumbrates how the multidisciplinary work of Graham—addressing such diverse cultural phenomena as suburbia, 1960s counterculture, television, and punk music—traced the emergence of a postwar “liberal” order of capitalism and its constitutive technologies of colonization and the domestication of social and urban environments.
Dan Graham: Pedagogue
Authors: Guagnini Nicolás 
Published: June 2022

Abstract
Artist and writer Nicolas Guagnini's obituary for his friend Dan Graham deploys the genre's tropes of anecdote and remembrance to elucidate the artist's idiosyncratic pedagogy. Both at the methodological and the art-historical levels these bits of conversations from over more than two decades touch on Graham's position towards his postminimalist peers, his approach to architecture, public space, writing, artistic genealogies, and anthropology.
Handbook of Feelings
Authors: Sia Tiffany 
Published: June 2022

Abstract
Hong Kong's National Security Law was passed on June 30, 2020, followed by a film-censorship amendment on October 27, 2021. While the public experienced the ensuing censorship as an absence and an occlusion of works, the mechanisms of censorship are opaque and bureaucratic, made effective through myriad methods. This article focuses on a first-person telling that weaves personal conversations, rumors, and everyday experiences in the new normal to analyze the evolving codes and reveal the trip wires that threaten the creation and presentation of films, artworks, and print materials in Hong Kong. Artists and filmmakers face a developing shadow bureaucracy, which they are only slowly coming to understand. Tracing the visible and invisible red lines through a group of mostly anonymized artists and practitioners—except for the author or those cited in the news—this essay confronts the haunting power of newly passed national-security laws to atomize fear, threaten some more than others, and generally to produce paranoia.
Gerronema confusum (Porotheleaceae), a new species from North China
Authors: ZHAO TAO-YU , FAN LI 
Published: June 2022

Gerronema confusum sp. nov. is described and illustrated from North China, which is diagnosed by the combination of grayish brown omphalinoid basidiomata, decurrent lamellae, a central stipe, smooth, ellipsoid to subglobose, inamyloid basidiospores, 1–2-spored basidia, abundant cheilocystidia, a pileipellis disrupted by clusters of pileocystidia, and a stipitipellis disrupted by caulocystidia. ITS-phylogeny supported G. confusum as a distinct species.