bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Features and Selection of Hypolipidemic Therapy in Patients with Coronary Artery Disease with “Possible” Familial Hypercholesterolemia
Authors: Mitchenko Olena I. , Timokhova Kateryna O. , Chulaievska Nataliia M. 
Published: September 2022

The aim. To optimize the diagnostic algorithm for patients with true “possible” familial hypercholesterolemia (FH) and differential diagnosis with hypercholesterolemia on the background of comorbid endocrinopathies for selection of optimal hypolipidemic therapy.
Materials and methods. We examined 130 patients with hypercholesterolemia and comorbid pathology (type 2 diabetes mellitus, hypothyroidism, obesity grade II-III). In each group, subgroups with low-density lipoproteins (LDL) ≥5 mmol/l were selected and followed up on the background of maximum tolerated doses of statins in combination with therapy aimed to compensate comorbid pathology. The control group consisted of 20 patients with verified FH.
Results and discussion. Combined dyslipidemia was detected in groups 1 and 3, pure hypercholesterolemia in group 2. Direct correlations between lipid profile and comorbid pathology characteristics were revealed. Patients of the subgroups with “possible” FH had higher atherogenicity of the lipid profile associated with comorbid pathology destabilization and high percentage of atherosclerosis of carotid and coronary arteries. According to the results of the follow-up, it was established that statin therapy and comorbid pathology compensation led to the achievement of target levels of LDL (group 3) or a reduction of LDL by 50% (group 1, 2). In patients of the control group, statin therapy with maximally tolerated doses did not show such results.
Conclusions. The cohort of patients defined as having “possible” FH is heterogeneous and may include patients with secondary dyslipidemia on the background of comorbid pathology destabilization, timely verification and treatment of which contributes to achieving the goals of lipid-lowering therapy. Taking into account that only obese patients reached the target level of LDL <1.8 mmol/l, combined lipid-lowering therapy is recommended for patients with hypothyroidism and diabetes. Refractoriness to statin therapy in patients with verified “possible” FH emphasizes the need for combined lipid-lowering therapy (ezetimibe, PCSK9 inhibitors).
SAĞLIK İŞLETMELERİNDE ETİK LİDERLİĞİN DİLE GETİRME DAVRANIŞLARI ARACILIĞIYLA İŞ PERFORMANSINA ETKİSİ: ÖRGÜTSEL AİDİYETİN DÜZENLEYİCİ ROLÜ
Authors: YILDIZ Ayşe Tuğba , DEMİRTAŞ Özgür 
Published: September 2022

ÖZET
Bu çalışmanın amacı dile getirme davranışı aracı (mediating) rolde iken etik liderlik davranışlarının iş performansı üzerindeki etkisini incelemektir. İlave olarak günümüzde bireylerin iş performansının artırılmasında etkili bir algı olan örgütsel aidiyet değişkeni de düzenleyici rolde çalışmada yer almaktadır. Bu amaç doğrultusunda Kayseri’de bulunan sağlık kurumlarında tam zamanlı olarak çalışan 415 sağlık çalışanı üzerinde anket tekniği ile veriler yüz yüze toplanmıştır. Çalışma sonucunda etik liderliğin iş performansını pozitif yönde etkilediği, dile getirme davranışlarının ise bu ilişkide kısmi aracı role sahip olduğu tespit edilmiştir. İlave olarak da örgütsel aidiyetin etik liderlik ve dile getirme davranışları ilişkisinde düzenleyici rolde olmadığı bulunmuştur.
Prevalence and structure of inflammatory periodontal diseases in tuberculosis in school-age children
Authors: Smolyar N.I. , Shylo M.M. 
Published: September 2022

Objective — to study the prevalence and structure of inflammatory periodontal diseases in respiratory tuberculosis patients and infected with mycobacterium tuberculosis (MTB) school-aged children.
Materials and methods. The examination was carried out in 168 (100 %) patients with respiratory tuberculosis and MBT-infected children and adolescents of school age (from 6 to 17 years) with inflammatory diseases of periodontal tissues. Among the examined schoolchildren, 102 (60.72 %) were school-aged children with respiratory tuberculosis (the first group). The second group included 66 (39.28 %) infected MTB schoolchildren. The control group consisted of 45 practically healthy school-age children. The conducted examination of the dental status included the study of the prevalence of periodontal pathology, the intensity of the lesion and the severity of its course in different age groups of school children.
Results and discussion. It was established that the prevalence of periodontal tissue disease in school-aged children with tuberculosis ((87.25 ± 2.36) %) and MTB-infected ((65.15 ± 2.15) %) exceeded that of healthy children ((24.45 ± 2.12) %) by 4.0 and 3.7 times, respectively. The most common pathology was an inflammatory lesion of the gums in the form of catarrhal gingivitis, which was almost 4 times higher than such data in children of the control group. The course of catarrhal gingivitis was diagnosed in the form of acute, chronic and exacerbation of the chronic process. At the same time as the prevalence of catarrhal gingivitis increased with age, the frequency of periodontitis increased in the children of the examined groups, the prevalence of which was most pronounced among patients with tuberculosis, much less among those infected with MTB. The assessment of the intensity of periodontal tissue damage using the PMA index revealed its increase with age, most pronounced among patients with tuberculosis, somewhat less among those infected with MTB.
Conclusions. The prevalence of inflammatory diseases of periodontal tissues in patients with respiratory tuberculosis and MTB-infected children increases with age and is manifested by gum damage in the form of both catarrhal gingivitis and periodontitis, the highest prevalence of this pathology was observed among 15—17-year-old schoolchildren with pulmonary tuberculosis, less is expressed in infected MTB.
Thyroid tuberculosis: rare location or rarely diagnosed? Literature review
Authors: Matvyeyeva S.L. , Shevchenko O.S. 
Published: September 2022

Objective — to study of the frequency, clinical picture, diagnosis and treatment of tuberculosis of thyroid gland.
Materials and methods. Analyses the date of the world experience and own observations.
Results and discussion. Thyroid tuberculosis is a less frequent localization of this disease. Currently, most authors believe that thyroid tuberculosis is diagnosed in 0.1–1 % of all known cases of tuberculosis. Clinical observations have found that the thyroid gland is more often involved in the tuberculous process with a generalized miliary process, and, as previously thought, in this case there are no clinical signs of damage to the thyroid gland. A variable clinical presentation of thyroid tuberculosis was demonstrated. It is usually presented with local symptoms associated with diffuse enlargement of the thyroid gland. It is difficult to estimate the quantity of diagnosed cases due to insufficient knowledge of the doctors about this pathology and difficulties of tuberculosis etiology diagnosis. Tuberculous etiology must be ruled out in all lesions on the median surface of the neck. Fine-needle biopsy can help to confirm the diagnosis of thyroid tuberculosis, but the final diagnosis is possible only with histological or cytological studies. The diagnosis of thyroid tuberculo­sis requires the use of most of all the methods used in the diagnosis of tuberculosis: from the simplest (such as X-ray or Mantoux test (with 2 international units of tuberculin) methods to modern rapid molecule-genetic tests XpertMTB/Rif that detect specific fragments of MTB DNA in serum or plasma). Ultrasound and computer tomography also help the clearing of the diagnosis. Surgical treatment in combination with antimycobacterial chemotherapy is effective.
Conclusions. Further investigations are needed to understand the definition, diagnosis and treatment of tuberculosis among other diseases of thyroid.
Impact of delayed initiation of antiretroviral therapy in patients with HIV infection
Authors: Shevelova O.V. , Shostakovich­–Koretska L.R. , Lytvyn K.Yu. , Kushnierova O.A. 
Published: September 2022

Objective — to analyze the effect of the duration of the period from the moment of infection to the appointment of antiretroviral treatment in patients with HIV infection as a predictor of an unfavorable course of the disease.
Materials and methods. A retrospective and prospective study was conducted among a cohort of people living with HIV (PLHIV), which included 450 patients. The observation lasted 60 months. 63 patients died from HIV-related causes, 14 from non-HIV and immune reconstitution inflammatory syndrome (IRIS) causes, 69 patients interrupted antiretroviral therapy (ART) for various reasons during the follow-up period. By the end of the follow-up period, 304 patients remained on ART. Statistical processing of the results was carried out using the STATISTICA v. 6.1 application package.
Results and discussion. Based on the results of a correlation analysis of clinical and laboratory parameters of a cohort of HIV-infected patients, 10 main risk factors were selected, including the delayed initiation of antiretroviral treatment. After 5 years of follow-up, the main reason for the loss of patients from the cohort was interruption of therapy — 69 (15.3 %) people, 63 (14.0 %) died from HIV-related causes, and 14 (3.1 %) died from causes unrelated to HIV and IRIS. Causes associated with the undesirable clinical outcomes of ART were noted in 30.4 % of people — allergic reactions, taking therapy together with anti-TB therapy, in turn, led to the development of IRIS and an increase in adverse events.
Conclusions. The analysis shows that despite the high intensity of the prescribed primary treatment regimens for patients with HIV infection, such a factor as the delayed initiation of ART has a significant negative impact on the further course of HIV infection and the development of adverse events, worsening the prognosis of the disease.
The Impact of Instagram Social Media and e-Mouth of words as a Marketing Strategy on Purchasing Decisions
Authors: Prastiwi Estik Hari 
Published: September 2022

Study this aim to prove and analyze the influence of social media Instagram and mouth of word on decision purchase by direct or through brand equity mediation. Method data collection used is with method questionnaire, sample study of 150 respondents. The method sample used namely purposive sampling, namely respondents who have buy fashion products in e-commerce at least twice. Method data analysis used WarpPls 7.0 . Research results show Instagram influential significant to decision purchase , word of mouth is influential significant to decision purchase. Brand equity is as mediation of Instagram's influence on decision purchases. Brand equity is also a mediation the influence of mouth of word on decision purchase
SIGNALLING THEORY STUDY: PREDICT FUTURE CASH FLOWS WITH EARNINGS AND CASHFLOWS IN CONSUMER GOODS INDUSTRIES BEFORE PANDEMIC ERA
Authors: Khasanah Uswatun , Samsi Nur , Choiri Choiri , Zainab Zainab 
Published: September 2022

This study aims to determine which of the cash flows and earnings have a better ability to predict future cash flows in the two years after the study period. This research was conducted on consumer goods industries listed on the Indonesia Stock Stock Trade in 2016 – 2019 employing a purposive examining procedure. (Dechow, Kothari, & Watts, 1997) found that earnings have a better ability to predict future cash flows than operating cash flows themselves. Another study conducted by (Dahler & febrianto, 2007) utilizing numerous straight relapse models found that operating cash streams for the current year have a better ability than profit in anticipating future working cash streams for both bunches of companies that have positive and negative benefits. Utilizing the same model, this study concludes that earnings have a better ability to predict future cash flows than cash flows themselves. However, cash flows still have a significant ability to predict future cash flows. In expansion, this consider too succeeded in demonstrating that profit has an incremental capacity to anticipate future cash streams.
REBOUND MODEL TO TOWARD REGIONAL ECONOMIC RESURRECTION POST COVID-19 PANDEMIC IN BANYUWANGI REGENCY
Authors: Suprihatin Endang , Hamid Abdul 
Published: September 2022

Banyuwangi Regency which is located in the eastern sunrise of Java seeks synergistically to restore the economy after the Covid-19 pandemic, namely by echoing the Banyuwangi Rebound program which contains three main program for the era of revival, First, the pandemic handling ecosystem consists of various steps to deal with Covid-19 and improve the level of health of citizens in general, in addition to handling pandemics such as us towards one hundred percent of childhood vaccination, various preventive, promotive, curative, and rehabilitative measures we integrate. Including towards zero stunting, village midwife support, people's nutritional supplements, spurring sports activities, and revitalization of school health units, the next ecosystem is economic recovery. Starting from MSME development programs, agriculture, infrastructure, rural development, to tourism. They are designed to create jobs and restore the economic movement of citizens. The third ecosystem is harmony strengthens social solidarity, develops human resources in terms of education, maintains environmental sustainability, to strengthen harmony between religious people. Banyuwangi Rebound is a comprehensive movement reaching all sectors and stakeholders to bring Banyuwangi able to Rebound amoung various challenges. Economic growth is starting to return positively. The wheels of the economy began to move, one of the indicators is financing from banks to MSME that are soaring. Banyuwangi's banking credit growth is far above the national average. In addition, the culture of innovation developed by the government continues to develop, in the midst of this pandemic, the poverty rate rose even though Banyuwangi experienced the lowest increase in East Java 0.1%.
A Phenomenological Study on the Lived Experiences of Self-Aware-Non-Fluent English Teachers
Authors: Rino Ushas Richel R. , Cortezano Glen P. , Yazon Alberto D. , Manaig Karen A. , Tesoro John Frederick B. 
Published: September 2022

This study delved into the lived experiences of self-aware-non-fluent English teachers in their instructional delivery to come up with practical strategies and ways to strengthen the delivery of instruction in using the English language. Accordingly, qualitative research design and hermeneutic phenomenological processes were utilized. In analyzing the acquired responses from the participants, the following steps were applied: (1) hermeneutic phenomenological reduction; (2) imaginative variation, where the possible meanings of horizons were attained through the individual and composite structural descriptions; lastly, (3) essence, where the synthesis and reflections were made to form implications. The epoche was also applied before and during the conduct of this qualitative research to suspend the researcher’s connection to the experiences of the participants and maintain bias-free data. Based on the testimonies gathered from the participants, 139 subordinate themes, 28 superordinate themes, and four (4) main themes were unveiled. Challenges encountered in using the English language in an English classroom, Practices in developing English language fluency in the classroom, Various training on enriching the English language fluency among English teachers; and Favorable experiences as English teachers were the four (4) main themes which highlighted all the significant occurrences in the classroom regarding English language fluency. As a result, a booklet entitled “I am a Pedagogue: Repertoire of English Fluency Enrichment Strategies” was crafted which emphasized strategies acquired from the lived experience of the participants and was intended to be applied by all the English teachers in Calamba City.

Keywords – English teachers, enrichment strategies, instructional delivery, non-fluency
Virtual Feedback for Compliance to Prescribed Exercise: A Randomized Crossover Trial
Authors: Visentin Denis , O'Brien Jane , Freeman Carlie , D'Orazio Alexandra , Barker Kate , Williams Andrew D. 
Published: September 2022

ABSTRACT

Background
To investigate the effect of a virtual feedback environment on compliance to prescribed session exercise load and to understand the user experience related to exercise participation.

Methods
Adult clients referred to an exercise physiology clinic wore a heart rate monitor while performing prescribed exercise twice per week over 2 intervention blocks of 2 weeks each. Participants undertook aerobic exercise both with and without a virtual feedback environment in random order. Compliance to prescribed exercise was assessed as heart rate relative to prescribed levels both within and across sessions. Participants reported average pain and rating of perceived exertion for the session and completed the PACES-8 enjoyment of exercise questionnaire at session completion. Treatment effects were assessed longitudinally using mixed-effects linear regression. At study completion, 2 focus groups (n = 12) were conducted and reported using thematic analysis.

Results
Participants (n = 14) demonstrated higher mean compliance to prescribed exercise under the treatment (101 ± 10%) compared to control (50 ± 10%) condition (MD = 51%; 95% CI: 21–80; P = 0.001). Similar scores were observed under both the treatment and control conditions for rating of perceived exertion (12.3 vs. 12.2: P = 0.86), pain (2.37 vs. 0.85: P = 0.29), and enjoyment of exercise (41.2 vs. 38.6: P = 0.49). Focus groups identified themes related to biofeedback, interactivity and engagement, goal setting, and the visual environment.

Conclusion
Immersive feedback technologies can be effective to assist individuals with chronic clinical conditions to perform aerobic exercise within prescribed intensity ranges. Wide acceptability requires linking the exercise modality to the immersive environment and developing clear and meaningful goals.
Crop Establishment Methods, Varieties and Levels of Zinc on Growth and Yield of Rice in Chitwan, Nepal
Authors: Pariyar Rajan , Shah Shrawan K. , Marahatta Santosh , Karki Tika B. 
Published: September 2022

With the aim of identifying the appropriate doses of Zinc in rice for different varieties under various establishment methods, an experiment was carried out in a strip-split plot design with three replications at Agriculture and Forestry University, Rampur, Chitwan during 2015-16. The treatment consists of two crop establishment methods (Transplanted rice (TPR) and Direct Seeded Rice (DSR)) in the vertical strip and two varieties (Hybrid Gorakhnath-509 and Sabitri) in the horizontal strip and four levels of ZnSO4 (0, 15, 30 and 45 kg ha-1) in sub-sub plot. The observations were recorded on growth, yield attributes, grain yield and economics. The research results revealed that the application of ZnSO4 @ 15 Kg ha-1 significantly increased the grain yield of DSR as compared to the non-application of ZnSO4. The higher grain yield of rice was because of increased yield attributes like effective tillers, thousand-grain weight and the number of filled grains per panicle. Crop establishment methods and varieties did not have a significant influence on the grain yield of rice. DSR had a lower cost of cultivation, higher net return and higher benefit-cost ratio as compared to TPR. The variety Sabitri had lower cost of cultivation, higher net return and higher benefit-cost ratio as compared to Gorakhnath-509. Similarly, the application of ZnSO4 @ of 15 Kg ha-1 produced the highest net return and the highest benefit-cost ratio. Therefore, ZnSO4 @ 15 kg ha-1 could be an option for increased yield and net return for DSR in Chitwan.
Reasonable Fertilization Improves the Conservation Tillage Benefit for the Yield of Winter Maize in Rice-based Cropping System of Central Inner Terai of Nepal
Authors: Marahatta Santosh , Karki Tika Bahadur 
Published: September 2022

To investigate the effects of fertilization, tillage, and their interaction on maize yield, an experiment on rice-maize was conducted on 2018/19 and 2019/20 at Agriculture and Forestry University (AFU), Rampur, Chitwan, Nepal. The experiment was in a split-plot with two establishment methods viz. (i) zero tillage followed after (fa) conventionally tilled dry direct seeded rice (ZT fa CT-DDSR) (ii) conventional tillage fa puddled transplanted rice (CT fa Pu-TPR) and four nutrient management practices, i.e. (i) recommended dose (100% RDF; 180-90-60 N-P2O5-K2O kg ha-1), (ii) Residue retention of rice crop @ 5 t ha-1 + 75% RDF (RR +75% RDF), (iii) Nutrient expert (NE) dose (150-50-90 N-P2O5-K2O kg ha-1), (iv) Rice residue @ 3.5 t ha-1 +75% RDF followed after brown/green manuring of Sesbania in rice (R+75% RDF fa BM/GM) and the treatments were replicated thrice. The data on yield and yield attributes were recorded and analyzed by R studio. Both crop establishment methods and nutrient management practices did not influence (p>0.05) the plant population, number of cobs per plant, number of grains per cob, thousand-grain weight, and sterility. The barrenness percentage was not significantly affected by the crop establishment methods but significantly (p>0.05) lower under residue retained treatments. Application of NE dose, sterility was significantly (p<0.05) reduced under ZT fa CT-DDSR. The average grain yield, straw yield, and harvest index (HI) were 6153 kg ha-1, 4547 kg ha-1, and 53.81% respectively. The two years average grain yield was statistically at par (p>0.05) for both crop establishment methods whereas application of NE dose, RR+75% RDF, and R+75% RDF fa BM/GM resulted in significantly (p<0.05) higher grain yield than obtained in the 100% RDF applied plots. Maize planting on zero tillage followed after CT-DDSR was equally productive and the use of a nutrient expert for nutrient recommendation or retention of residues with a 25% reduction of the RDF had a yield advantage over the present RDF.
Scientific Model Development for Machinery Safety using Machine Reliability, Integrity and Availability
Authors: Nesan Kartikeyan Patma , Buang Azizul , Kaniapan Sivabalan , Zaini Dzulkarnain 
Published: September 2022

Introduction: Machines are equipment that increases productivity and efficiency in a workplace. Machine Reliability, Integrity, and Availability are the most critical factors to ensure machinery safety in a workplace.
Methods: Throughout this study, a series of reviews of previous literature are described in relation to the elements of reliability, integrity and availability. This study examines the methods used to investigate levels of each element as well as the results of performing the analysis. Each review is chosen from the aspect of the safety feature that can be interpreted from the research study. A scientific model that utilizes an improved Bottom-up Approach is proposed to further improve the worker's safety and enhance the productivity of an industry.
Results: Research shows that the chosen reviews have positive and negative change towards the level of machinery safety and a more substantial approach is needed to further strengthen the issue. The proposed model combines the effort of employee and various management organization as a team. The model is validated using Bias- Variance Trade off method that analyses the proposed model in a 27MW power plant with a selection of employee and management.
Conclusion: Model validation proves that the proposed model is an effective method to increase the machinery reliability, integrity and availability in a workplace. The scientific methodology provided will help management as a team to avert mechanical accidents from occurring at an initial stage.