bluuebunny/crossref_metadata_2025_split huggingface dataset:
Echocardiographic assessment alone is inadequate for determining elevated left sided filling pressures in patients with cardiogenic shock
Authors: Brahmbhatt D H , Scolari F L , Doumouras B S , Billia F , Szekely Y 
Published: October 2022

Abstract

Background
Left atrial (LA) filling pressure assessment is of paramount importance in tailoring treatments for patients with cardiogenic shock (CS). ESC guidelines advocate for the use of mitral inflow Doppler and mitral annulus tissue Doppler measurements to predict elevated left atrial pressure in clinical practice. Echocardiographic measurement of LA pressures could reduce the need for invasive monitoring in CS patients, but its utility remains unproven in this population.

Purpose
We assessed the validity of mitral inflow velocity and mitral annulus velocity indices to determine LA pressures, correlating them with invasive measurement of pulmonary capillary wedge pressure (PCWP) in CS patients admitted to the cardiac intensive care unit (CICU).

Methods
We prospectively evaluated consecutive patients who underwent pulmonary artery catheter insertion in the CICU, measuring their haemodynamic parameters, including PCWP. This was immediately followed by a transthoracic echocardiography (TTE) performed by a critical care cardiologist, blinded to the invasive measurements. The early (E) and late (A) mitral inflow velocities were measured using mitral inflow Doppler and septal and lateral mitral annulus velocities (e') were measured using tissue Doppler, all in the apical 4-chamber view. TTE images were later reported by a second cardiologist, blinded to the invasive measurements and the patient. Correlations between E; E/A ratio; E/e' ratio and PCWP were evaluated using Pearson's correlation.

Results
Sixty patients were recruited into the study, aged 58±14 years, 27% female, with 96 assessments undertaken. The majority (55%) of patients were SCAI stage C, with 14% having had a cardiac arrest prior to CICU admission and 27% required mechanical ventilation at the time of assessment. Mean PCWP was 16.0±6.5 mmHg. Full mitral valve Doppler and tissue Doppler profiles were measured in 67 (70%) assessments, limited due to E/A fusion, atrial fibrillation and limited acoustic windows. There was only weak correlation between PCWP and E/A ratio (R=0.33, p=0.01), with no correlation between PCWP and the other measured values (Table 1), including E/e'. The AUC for identifying patients with elevated PCWP (≥15 mmHg) using E/A ratio was 0.67 (p=0.02), although there was no suitable value to use as a cut off with adequate sensitivity and specificity (Figure 1).

Conclusion
Echocardiographic non-invasive assessment of left sided cardiac filling pressures is technically challenging in patients with CS. Even when possible, there is weak correlation between echocardiographic and invasive measurements, suggesting limited value in this technique. Alternative non-invasive modalities, such as lung ultrasound, should be investigated in this population to assist clinical assessment.

Funding Acknowledgement
Type of funding sources: None.
Propofol versus midazolam sedation in patients with cardiogenic shock – an observational propensity-matched study
Authors: Scherer C , Kleeberger J , Kellnar A , Binzenhoefer L , Luesebrink E , Stocker T J , Thienel M , Deseive S , Braun D , Petzold T , Brunner S , Hagl C , Hausleiter J , Massberg S , Orban M 
Published: October 2022

Abstract

Introduction
Benzodiazepines are recommended as first line sedative agent in ventilated cardiogenic shock patients, although data regarding the optimal sedation strategy are sparse. On our cardiac ICU, midazolam was used as first line sedation until 2016, whereas soybean oil formulated propofol was used preferentially since 2017.

Purpose
The aim of this study was to investigate the hemodynamic effects of propofol versus midazolam sedation in our cardiogenic shock registry.

Methods
Mechanically ventilated patients suffering from cardiogenic shock were retrospectively enrolled from a cardiogenic shock registry. 174 patients treated predominantly with propofol were matched by propensity-score to 174 patients treated predominantly with midazolam.

Results
Catecholamine doses were similar on admission but significantly lower in the propofol group on days 1–4 of ICU stay (Figure 1). Mortality rate was 38% in the propofol and 52% in the midazolam group after 30 days (p=0.002, Figure 2). Rate of ≥BARC3 bleeding was significantly lower in the propofol group compared to the midazolam group (p=0.008). Age, gender, first lactate measured on ICU, first GFR measured on ICU, cardiac arrest, coaxial left ventricular assist device and sedation with midazolam were significantly associated with ICU mortality.

Conclusion
In this observational cohort study, sedation with propofol in comparison to midazolam was linked to a reduced dose of catecholamines, decreased mortality and bleeding rates for patients with cardiogenic shock. Based on this study and in contrast to current recommendations, propofol should be given consideration for sedation in cardiogenic shock patients.

Funding Acknowledgement
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Deutsche Forschungsgemeinschaft
24h SCAI stage reclassification to predict outcome. Insights from the prospective Altshock-2 registry
Authors: Morici N , Frea S , Ditali V , Briani M , Bertaina M , Ravera A , Sorini Dini C , Moltrasio M , Saia F , Corrada E , De Ferrari G M , Garatti L , Colombo C , Tavazzi G , Pappalardo F 
Published: October 2022

Abstract

Background
Cardiogenic shock (CS) includes several phenotypes of congestion or hypoperfusion with heterogenous hemodynamic features. Timely prognostication with scoring tools is warranted to identify patients requiring escalation to mechanical circulatory support (MCS) and to avoid futility.

Purpose
Accordingly, we explored the role of the updated Society for Cardiovascular Angiography and Interventions (SCAI) stages classification on in-hospital mortality using a prospective national registry.

Methods
The Altshock-2 Registry includes 237 patients with CS of all etiologies enrolled between March 2020 and February 2022 in 11 Italian Centers. Patients were classified according to the admission SCAI stages (assigned prospectively and independently updated according to the most recently released version); 24-hour re-assessment was prospectively performed in 201 patients. In-hospital mortality was evaluated for association with admission and 24 hours SCAI stages adjusted for the most relevant clinical covariates.

Results
Of the 237 patients included, 20 (8.4%) had SCAI shock stage B, 132 (55.8%) SCAI stage C, 60 (25.3) SCAI stage D and 25 (10.5%) SCAI stage E. Patients in stage B had the worst reclassification at 24-hours, with 42% of them showing worsened status and only 8% improving. In-hospital mortality was 38%. The revised SCAI stages at baseline were not independently associated with in-hospital mortality, whereas the SCAI classification at 24-h correctly and independently predicted mortality (the rate of in-hospital death was 18% for patients in SCAI shock stage B, 27% for SCAI shock stage C, 64% for SCAI shock stage D, 100% for SCAI shock stage E). At the multivariate analysis (adjusted for age, gender, eGFR, inotropic score and MCS) only SCAI classification at 24-hour evaluation was an independent predictor of in-hospital mortality (OR and 95% CI were, respectively, 3.32, 0.36–30.63, p=0.290 for SCAI stage C and 13.07, 1.69–146.3 for SCAI stage D, with E perfectly predicting because all patients died).

Conclusions
The revised SCAI stage classification may improve prognostication only at 24-hour evaluation. Aggressive treatment (either pharmacological or with MCS escalation) should be tailored in order to achieve prompt clinical improvement within the first 24-hours; refractory SCAI stage E at 24 hours portends dismal prognosis.

Funding Acknowledgement
Type of funding sources: None.
Long-term neurological intact survival and quality of life after refractory out-of-hospital cardiac arrest treated with rescue mechanical circulatory support
Authors: Rasalingam Moerk S , Kristensen L Q , Osterlund L G , Christensen S , Tang M , Terkelsen C J , Eiskjaer H 
Published: October 2022

Abstract

Background
Mechanical circulatory support (MCS) with either veno-arterial extracorporeal membrane oxygenation (V-A ECMO) or Impella has emerged as a rescue therapy for refractory out-of-hospital cardiac arrest (OHCA). However, only short-term outcome is specified and most studies do not report follow-up beyond six months. Long-term survival and quality of life in this high-risk population remains unknown.

Purpose
To determine long-term neurological intact survival and quality of life in patients with refractory OHCA treated with MCS.

Methods
This was an observational, single-centre study of OHCA-patients from January 2015 to December 2019. Patients treated with MCS for OHCA were compared with patients receiving conventional cardiopulmonary resuscitation (CPR). A follow-up of long-term survivors in the MCS group was conducted (&gt;1 year after arrest). This included health related quality of life questionaries (Short Form-36 [SF-36]) and assessment of neurological function with Cerebral Performance Category (CPC). Good neurological outcome was defined as CPC 1 and CPC 2.

Results
A total of 1015 with OHCA were included; 101 received MCS for refractory cardiac arrest. Among these V-A ECMO was deployed in 97 patients and Impella in 4 patients. The MCS group had significantly longer low-flow times compared to the conventional group (105 [IQR, 94–123] minutes versus 18 [IQR 10–39] minutes) and were more metabolically deranged upon arrival at hospital (Table 1). In patients receiving MCS, the hospital discharge rate was 27% and good neurological outcome was seen in 93% among patients discharged. At follow-up, 15 out of 21 long-term survivors participated. Median follow-up time was 4.8±1.6 (range 2.8–6.1 years). Mean age at follow-up was 61±7.3 years, 11 (73%) were men. Neurological outcome with CPC 1 was found in 12 patients (80%), with CPC 2 in 2 patients (13%), and with CPC 3 in 1 patient (7%). Two had improved neurological status from CPC 2 to CPC 1 since discharge. Mean scores of the SF-36 revealed an overall high level of psychical and mental health in long-term survivors (Figure 1).

Conclusion
Long-term survival with good neurological outcome was high in patients with refractory OHCA treated with MCS despite prolonged resuscitation and severe metabolic derangement. These patients may expect a reasonable quality of life after discharge.

Funding Acknowledgement
Type of funding sources: Public hospital(s). Main funding source(s): Department of Cardiology, Aarhus University HospitalSnedkermester Sophus Jacobsen og hustru Astrid Jacobsens Fond
Neurological evolution of patients in coma at 72 hours after out-of-hospital cardiac arrest
Authors: Badosa Gali E , Nunez Torras M , Aboal Vinas J , Pascual Mayans J , Kassem Perez H , Singh M , Brugada Terradellas R , Loma-Osorio Ricon P 
Published: October 2022

Abstract

Introduction
Establishing neurological prognosis after out-of-hospital cardiac arrest (OHCA) safely and early in those patients who remain in a coma at 72 hours of admission.

Purpose
To analyze the prognostic performance of neuron-specific enolase (NSE), Somatosensory evoked potentials (SSEPs) and electroencephalogram (EEG) in these patients.

Methods
Prospective and observational study, including all OHCAs admitted to a Cardiovascular Intensive Care Unit (CICU) of a tertiary hospital. Neurological stratification was performed at 72 hours with NSE (poor prognosis &gt;60 ng/mL), SSEP (poor prognosis in the absence of N20) and EEG (poor prognosis). The sensitivity and specificity of each test for poor prognosis were calculated, as well as the three tests together.

Results
Between 03/17/2013 and 02/24/2022, 422 OHCAs were registered, of which 170 patients remained in a coma at 72 hours. The EEG had a sensitivity of 84% and a specificity of 89% due to poor prognosis. SSEPs had a sensitivity of 68% and a specificity of 98% due to poor prognosis. The NSE had a sensitivity of 67% and a specificity of 100% due to poor prognosis. The three tests were able to be performed on 110 patients, the sensitivity for poor prognosis of the three combined tests was 49% and the specificity was 100%.

Conclusions
In patients in a coma at 72 hours of OHCA, the most specific test to establish a poor prognosis was SSEP and the most sensitive was EEG. The combination of the three had a specificity of 100%.

Funding Acknowledgement
Type of funding sources: None.
Prevalence of atrial myopathy among hypertrophic cardiomyopathy patients without atrial fibrillation
Authors: Pagourelias E , Boulmpou A , Evangeliou A , Zormpas G , Alexandridis G , Kotzadamis D , Vergopoulos S , Tsavousoglou C , Antoniadis A , Mavroudi M , Papadopoulos C E , Tzikas S , Fragakis N , Vassilikos V P 
Published: October 2022

Abstract

Background
Atrial myopathy (AM) is an entity reflecting left atrial (LA) structural and electrical remodeling, connected to atrial fibrillation (AF) development and heart failure progression in various substrates. In hypertrophic cardiomyopathy (HCM), prevalence of AM beyond AF and its correlations are not fully investigated.

Purpose
Aim of this study was to estimate the prevalence of AM in a cohort of HCM patients without AF history through assessment of LA volume index (LAVI), LA reservoir strain (LARS) and total atrial conduction time (TACT) (estimated by tissue Doppler imaging). Additionally, to investigate AM indices' correlation with other phenotypic and functional characteristics of HCM.

Methods
We included 50 HCM patients (60±16 years, 80% male, maximum wall thickness 18.6±4.1mm) without history of AF who have consecutively undergone 2D-speckle tracking echocardiography and cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE). TACT and LARS measurement is shown on left panel. Burden of fibrosis (percentage of LV mass) was defined by LGE extent (&gt;5 standard deviations compared to nulled myocardium) in CMR slices. Cut-off points for TACT, LAVI and LARS were adopted by literature (≥115 msec, ≥34 mL/m2 and &lt;21.3% respectively).

Results
All HCM patients had preserved EF (61.8±8%), while 13 (26%) presented outflow tract obstruction and 4 (8%) diastolic dysfunction stage≥2. LGE was observed in 32 patients (64%) occupying 7.2±5% of left ventricular (LV) mass. Mean TACT was 139.9±22 msec, with LAVI being 30.8±16.1 mL/m2 and LARS 27.6±13.9%. After assessing prevalence of AM parameters, 41 patients (82%) presented a prolonged (≥115 msec) TACT with only 13 of them having also a significantly dilated LA (≥34 mL/m2) and 16 an impaired LARS. Among HCM demographic, phenotypic and functional characteristics tested, age and LV mass index were found to be the only independent regressors of TACT (r=0.54, p&lt;0.0005 and r=0.44, p=0.002 respectively, right panels), while E/E' (r=−0.44, p=0.003) and fibrosis extent (r=0.36, p=0.02) were the strongest predictors of LARS and LAVI values respectively.

Conclusions
Atrial electro-mechanical delay assessed through TDI based TACT, is the most frequent AM parameter among HCM patients irrespective of AF and even before LA dilatation and LA strain impairment. AM parameters seem to correlate with various morphological and functional characteristics of HCM, their significance, however, in predicting progression towards AF development or HF presentation remains to be elucidated.

Funding Acknowledgement
Type of funding sources: None.
Amyloidosis of the aortic valve in patients with degenerative and bicuspid aortic stenosis
Authors: Perez E , Abedat S , Meir K , Pollak A , Shapira O , Erez E , Leibowitz D , Asleh R , Amir O , Beeri R 
Published: October 2022

Abstract

Introduction
Aortic stenosis (AS) is a common valvular disease, resulting in substantial morbidity and mortality. In younger patients, AS may occur as part of the bicuspid aortic valve (BAV) syndrome. Transthyretin cardiac amyloidosis (ATTR-CA) is an infiltrative disorder caused by the extracellular deposition of insoluble amyloid-derived fibrils. Recent studies have shown the presence of ATTR-CA in 4%-29% of degenerative AS patients. We hypothesized that amyloidosis may be involved in valve injury leading to AS.

Material and methods
We studied the aortic valves of 124 patients who underwent surgical aortic valve replacement at our institution over the last decade, included in our cardiosurgical database. Valves from 86 degenerative AS patients were compared to a control group of 38 patients with BAV stenosis. Patients with pure aortic regurgitation, history of rheumatic disease, or severe renal disease were excluded. The slides were stained with Congo red, and Thioflavin S then examined with regular, fluorescence and polarized light microscopy.

Results
In the degenerative AS group, Congo red and Thioflavin S staining was positive in 63% of the valves and 37% negative. The bicuspid AS group showed 68% positive and 32% negative for the Congo Red and Thioflavin S stains.

Discussion and conclusion
Our results indicate the presence of valvular amyloidosis in patients with AS, whether due to degenerative or congenital etiologies. This corroborates several recent studies. Intriguingly, there was an equally positive Congo red and Thioflavin S signal in bicuspid aortic valves. We speculate that the positive staining in the BAV group may indicate an inflammatory process associated with valve pathology inducing the accumulation of amyloid, and thus may not be transthyretin, as we expect in the experimental group. Another explanation may be that amyloidosis may be an epiphenomenon of valve “wear and tear” and not related to the pathogenesis in either etiology. Specific TTR immunofluorescence is underway to elucidate this question.

Funding Acknowledgement
Type of funding sources: None.
Impact of left ventricular contractility on mitral annular motion in an acute animal model
Authors: Persson R M , Dahl Aguilera H M , Kvitting J P , Grong K , Salminen P R , Svenheim B , Leiknes A , Stangeland L , Haaverstad R , Urheim S 
Published: October 2022

Abstract

Background
We know that the ventricular function has a profound effect on the mitral valve in chronic disease with ventricular remodeling. However, acute effects of ventricular function on the mitral valve apparatus are not well understood.

Purpose
To investigate the effect of left ventricular (LV) contractility on all aspects of mitral annular motion.

Methods
Eight piezoelectric transducers were implanted equidistantly around the mitral annulus in ten pigs. Sonomicrometer array localization recorded transducer position after weaning from bypass. LV contractility was evaluated by the slope of the end-systolic pressure-volume relationship. Mitral annular area was calculated from cubic spline interpolation through the annular points. Circularity and non-planarity angle were calculated from principal component analysis. Mitral annular excursion was calculated as the projected distance from the annular geometric mean point to the least square plane of the mitral annulus in end diastolic configuration.

Results
LV contractility was strongly associated to change in mitral annular area and mitral annular excursion (r=0.88, p&lt;0.001 and r=0.90, p&lt;0.001, respectively). Change in non-planarity angle was only moderately associated with LV contractility (r=0.68, p&lt;0.03), whereas circularity was not (r=0.05, p&lt;0.089).

Conclusions
LV contractility was closely related to mitral annular size reduction and apicobasal annular excursion, and only moderately associated to folding of the mitral annular saddle shape. No associations were found with change in mitral annular circularity. This is to our knowledge the first detailed description of the acute relationship between LV contractility and mitral annular dynamics.

Funding Acknowledgement
Type of funding sources: Public Institution(s). Main funding source(s): Western Norway Regional Health Authority Research Grant
Atrial extrasystoles unmask early electropathology in pediatric congenital heart disease
Authors: Ramdat Misier N , Taverne Y J H J , Van Schie M S , Kharbanda R K , Van De Woestijne P C , Van Leeuwen W J , Bartels B , Bogers A J J C , De Groot N M S 
Published: October 2022

Abstract

Background
Despite improvement in (timing of) of intervention or surgery, atrial fibrillation (AF) still occurs more often and at a younger age in patients with congenital heart disease (CHD) than in the general population. This suggests that in this population atrial conduction is already affected in an early stage.

Purpose
To unmask early, enhanced non-uniform anisotropic atrial conduction in pediatric patients with CHD by examining the impact of spontaneous aberrant atrial extrasystoles (AES) on atrial conduction.

Methods
Twenty-one pediatric patients with various CHD (mild 43%, moderate 24% and severe 33%) (median age=1.8 years [0.2–7.3]) undergoing primary cardiac surgery were included for an intra-operative epicardial mapping of both atria, including Bachmann's bundle. Conduction velocity (CV), localized areas of conduction delay and/or block (CD, CB and continuousCDCB) and unipolar electrogram (EGM) characteristics (voltages and amount of fractionated potentials) were quantified during sinus rhythm (SR) and compared with corresponding AES beats.

Results
During 41 AES median unipolar voltage and CV decreased compared to corresponding SR beats (7.08 [5.50–9.10] mV vs. 5.71 [3.95–7.48] mV, p&lt;0.001); 87.9 [76.7–101.6] cm/s vs. 84.5 [73.0–93.6] cm/s, p=0.013; respectively), whereas the amount of fractionated potentials increased (12.7 [3.5–18.2] % vs. 19.5 [10.5–30.0] %, p&lt;0.001). Conduction disorders, consisting of CD, CB and cCDCB, were more prominent during AES (4.5 [2.3–6.3] %; 1.5 [0.0–4.3] %; 6.3 [2.6–11.2] %, respectively) (all p≤0.006). Differences in EGM morphology and conduction heterogeneity were not influenced by the degree of the prematurity of AES (p&gt;0.05).

Conclusions
AES in pediatric patients with CHD cause localized areas of conduction slowing and block, potentials with lower unipolar voltages and a higher degree of fractionation compared to SR potentials, independent of its prematurity. Our findings indicate that in pediatric patients with CHD, early, enhanced non-uniform anisotropic atrial conduction is already present and can be unmasked by AES. These insights are the first step in further understanding the time course of AF in CHD patients.

Funding Acknowledgement
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): CVON-AFFIPNWO-Vidi