bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secondary Fast Breakdown in Narrow Bipolar Events
Authors: Li Dongshuai , Luque Alejandro , Gordillo‐Vázquez F. J. , Silva Caitano da , Krehbiel Paul R. , Rachidi Farhad , Rubinstein Marcos 
Published: March 2022

AbstractThe physical mechanism of Narrow bipolar events (NBEs) has been studied for decades but it still holds many mysteries. Recent observations indicate that the fast breakdown discharges that produce NBEs sometimes contain a secondary fast breakdown that propagates back in the opposite direction but this has not been fully addressed so far in electromagnetic models. In this study, we investigate fast breakdown using different approaches that employ a Modified Transmission Line with Exponential decay (MTLE) model and propose a new model, named “rebounding MTLE model,” which reproduces the secondary fast breakdown current in NBEs. The model provides new insights into the physics of the fast breakdown mechanism.
Pipe Dreams: The Effects of Stream Bank Soil Pipes on Hyporheic Denitrification Caused by a Peak Flow Event
Authors: Lotts W. Seth , Hester Erich T. 
Published: March 2022

AbstractPeak flow events in gaining stream/river channels cause lung model hyporheic exchange with the banks (bank storage), which fosters beneficial reactions as polluted channel water cycles through riparian groundwater. Soil pipes are common along stream/riverbanks, and enhance exchange, yet their effect on reactions such as denitrification is unknown. We used MODFLOW with the Conduit Flow Package to simulate lung model exchange during a peak flow event in a section of stream bank/riparian soil with soil pipes, and MT3D‐USGS to estimate nitrate transport and denitrification. We varied soil matrix hydraulic conductivity (K) and first‐order reaction constant (k), as well as soil pipe density, length, and height above the initial channel water surface elevation (H). The addition of soil pipes enhanced stream bank (riparian) denitrification relative to banks without pipes, e.g., a 76% increase due to adding a single 1.5 m pipe. Denitrification increased linearly with pipe density but exhibited nonlinear trends with other parameters. Sensitivity analysis revealed length and density to be most influential. Soil pipe enhancement of denitrification was governed by hyporheic volume in most cases in our study. Exceptions included (a) coarse soil (K = 10−3 m/s) and (b) lowkandH > 0. Scaling our results to the stream corridor scale estimated that five soil pipes per m cumulatively induced 3% nitrate removal along a 1 km reach. Overall, soil pipes enhanced advection of nitrate into the banks, and also increased residence times of that nitrate under certain conditions, which together enhanced denitrification. This enhancement has implications for excess nitrate management in watersheds.
Estimating Soil Water Retention Curve by Extreme Learning Machine, Radial Basis Function, M5 Tree and Modified Group Method of Data Handling Approaches
Authors: Rastgou M. , Bayat H. , Mansoorizadeh M. , Gregory A. S. 
Published: March 2022

AbstractThis study was conducted to assess the applicability of novel types of neural network methods (extreme learning machine (ELM), radial basis function (RBF), modified group method of data handling (M‐GMDH)) and M5 tree methods for the prediction of the soil water retention curve (SWRC) and compare their performance with that of derived methods and pedotransfer functions (PTFs) of other studies for soils in Iran. Then, 15 PTFs were developed. Predictions were evaluated by the integral root mean square error (IRMSE), integral mean error (IME), Akaike's information criterion (AIC), and coefficient of determination (R2). The RBF‐based PTFs were better than the M5 tree, M‐GMDH, and ELM‐based PTFs in terms of the IRMSE criterion in the testing step. Also, PTFs and methods developed in the present study were more reliable than other derived PTFs and methods by diﬀerent researchers. The values of the IRMSE and R2 in the best PTFs (with inputs of sand, clay, total porosity and the moisture content at field capacity and permanent wilting point) of the testing data set of the RBF method were 0.037 cm3cm−3 and 0.988, respectively. For the testing data set, the average values of the IRMSE criterion for all the PTFs of the RBF, ELM, M‐GMDH, and M5 tree methods were 0.051, 0.062, 0.055, and 0.054 cm3cm−3, respectively. Therefore, the differences were considerable only between the ELM and other methods. The IRMSE criterion results of the testing data set showed the suitability of the RBF method in the development of PTFs for the prediction of the SWRC.
Enhanced NAPL Removal and Mixing With Engineered Injection and Extraction
Authors: Wang Yufei , Fernàndez‐Garcia Daniel , Sole‐Mari Guillem , Rodríguez‐Escales Paula 
Published: March 2022

AbstractAquifer remediation with in‐situ soil washing techniques and enhanced oil removal typically involves the injection of liquid solutions into the geological formation to displace and mobilize non‐aqueous phase liquids (NAPLs). The efficiency of these systems is oftentimes low because the displacing fluid bypasses large quantities of NAPL due to the inherent complexity of a heterogeneous natural system. Here, engineered injection and extraction (EIE) generated by rotating periodic injection is proposed as a method to enhance NAPL removal and mixing. To evaluate the method, we perform two‐phase flow simulations in multiple realizations of random permeability fields with different correlation structures and connectivity between injection and extraction wells embedded in a five‐spot pattern. Results show that EIE can significantly improve removal efficiency and mixing depending on several controlling factors. The effects of EIE are more significant under unfavorable conditions, that is, when injection and extraction wells are well‐connected through preferential channels, permeabilities are highly heterogeneous, and/or the mobility ratio between the wetting and the non‐wetting fluids is larger than one. Removal efficiency reaches its maximum value when the Kubo number is close to one, that is, when the saturation front travels one range of the permeability field in an injection pulse. These effects can develop in just a few cycles. However, removal efficiency should undergo first an early stage with detrimental effects in order to maximize removal in the long term. EIE not only enhances NAPL removal and mixing but also reduces the uncertainty, making the system more reliable and less dependent on heterogeneity.
Seasonal and Longitudinal Variations in Suspended Load Connectivity Between River Channels and Their Margins
Authors: Renshaw C. E. , Dethier E. N. , Landis J. D. , Kaste J. M. 
Published: March 2022

AbstractInput of organic matter into stream channels is the primary energy source for headwater ecosystems and ultimately carbon to the oceans and hence is an important component of the global carbon cycle. Here, we quantify organic‐rich fine sediment mobilization, transport, and storage in a Strahler fourth‐order stream during individual intermediate‐sized storm events. By combining measurements of fallout radionuclides (FRNs)7Be and210Pb and stable water isotopes with a conceptual model of suspended load trapping by channel margins, we find that the channel bed was consistently a source of suspended load to the channel margins. Relative to storage on the channel margins, suspended load export increased through the spring and summer, perhaps related to the in‐channel decomposition of organic debris as indicated by its FRN exposure age and changing bulk δ13C composition. Trapping of suspended load by riparian margins limits sediment transport distances, which, given sufficient discharge to fully suspend the load, is nearly independent of stream discharge for sub‐bankfull discharges. Limited data indicate that the fractional size of the channel margins where trapping occurs decreases with increasing watershed area. Increasing transport length and decreasing fractional margin area with increasing watershed area results in a systematic downstream decoupling of the channel from local terrestrial organic matter exchange. These findings provide a framework for understanding suspended load dynamics in formerly glaciated regions where sediment production and fluxes are generally low and thus the annual input of organic debris is a major component of suspended load budget.
Exploring the Influence of Seasonal Cropland Abandonment on Evapotranspiration and Water Resources in the Humid Lowland Region, Southern China
Authors: Yan Renhua , Li Lingling , Gao Junfeng , Huang Jiacong 
Published: March 2022

AbstractSeasonal abandonment in the previously rice‐based rotation system is increasingly prevalent worldwide particularly in southern China. Assessing the effect of this abandonment on evapotranspiration (ET) and water resources is of major importance for regional water cycle change and agricultural water management. This study analyzed the ET characterization of rice‐winter rape and rice‐winter fallow rotation systems and its relation to weather factors in a humid lowland region, southern China based on a half‐hourly ET measurement with Bowen ratio energy balance system from 2017 to 2020. Then the strategic modeling experiment combining ET and rainfall‐runoff models was used to explore the land abandoning effect on ET and water resources. The results showed that the daily ET values of the rice, rape, and fallow seasons were 3.30 ± 1.89, 1.31 ± 1.31, and 1.55 ± 1.19 mm/d, respectively. The averaged summed ET values of the rice‐winter rape and rice‐fallow rotation systems were 652.3 and 737.8 mm, respectively. Net radiation (Rn) was identified as the most critical weather factor for ET of all seasons. Air temperature and water vapor pressure deficit mainly affected ET indirectly through the path of Rn. Compared with the previously winter rape, the change in daily ET caused by seasonal abandonment was 0.13 ± 0.11 mm/d. This abandonment‐induced ET change increased the average daily storage deficit by 12.0% and groundwater depth by 4.5%, while reduced the daily runoff by 20.3%.
Disturbances in the Ionosphere That Accompanied Typhoon Activity in the Vicinity of China in September 2019
Authors: Chernogor Leonid F. , Garmash Kostyntyan P. , Guo Qiang , Rozumenko Victor T. , Zheng Yu , Luo Yiyang 
Published: March 2022

AbstractWe have acquired HF Doppler measurements and studied the dynamics of the ionosphere in the ∼100–300 km altitude range during the 1–10 September 2019 period of typhoon activity near the People's Republic of China (PRC). The multifrequency multiple path system located at the Harbin Engineering University campus, the PRC, and probing the ionosphere at oblique incidence was used to identify the effects from the typhoons. The response of the ionosphere to the Typhoon Lingling was detected along three adjacent radio‐wave propagation paths where chaotic and quasiperiodic variations in the Doppler shift and a significant (from −1 to 1 Hz or greater) Doppler spectrum broadening were observed to occur. The Doppler spectrum chaotic variations are due to plasma turbulence generated by typhoons in the ionosphere, and the Doppler shift quasiperiodic variations along the main ray are due to infrasound and atmospheric gravity waves (AGWs) launched by the typhoons. The relative amplitude of quasiperiodic variations in the electron density in the field of the infrasound wave reached several percent, and in the field of the AGW attained from ten to a few tens of percent. The effects of the Typhoon Faxai during 9/10 and 10/11 September 2019 nights were accompanied by a 27% decrease in the electron density in the ionospheric E and F regions. At the closest approach of the Typhoon Faxai to the ionosonde during 8/9 September 2019 night, when it had the largest energy, a 56% increase was detected in the ionospheric F region electron density.
The impact of catch-up bivalent human papillomavirus vaccination on cervical screening outcomes: an observational study from the English HPV primary screening pilot
Authors: Rebolj Matejka , Pesola Francesca , Mathews Christopher , Mesher David , Soldan Kate , Kitchener Henry 
Published: March 2022

Abstract
Background
In England, bivalent vaccination (Cervarix) against high-risk human papillomavirus (HR-HPV) genotypes 16/18 was offered in a population-based catch-up campaign in 2008–2010 to girls aged 14–17 years. These women are now entering the national cervical screening programme. We determined the impact of catch-up bivalent vaccination on their screening outcomes.

Methods
We studied the overall and genotype-specific screening outcomes in 108,138 women aged 24–25 (offered vaccination) and 26–29 years (not offered vaccination) included in the English HPV screening pilot between 2013 and 2018.

Results
At 24–25 years, the detection of high-grade cervical intraepithelial neoplasia (CIN2+) associated with HPV16/18 decreased from 3 to 1% (p < 0.001), with estimated vaccine effectiveness of 87% (95% CI: 82–91%). The detection of any CIN2+ halved from 6 to 3% (p < 0.001), with an estimated vaccine effectiveness of 72% (95% CI: 66–77%). The positive predictive value of a colposcopy for CIN2+ decreased for both low-grade (p < 0.001) and high-grade (p = 0.02) abnormalities on triage cytology. The decreases in screen-detected abnormalities at age 26-29 were of a substantially smaller magnitude.

Conclusions
These data confirm high effectiveness of bivalent HPV vaccination delivered through a population-based catch-up campaign in England. These findings add to the rationale for extending screening intervals for vaccinated cohorts.
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration
Authors: Zou Ming , Ke Qin , Nie Qian , Qi Ruili , Zhu Xingfei , Liu Wei , Hu Xuebin , Sun Qian , Fu Jia-Ling , Tang Xiangcheng , Liu Yizhi , Li David Wan-Cheng , Gong Lili 
Published: March 2022

AbstractAtrophic (“dry”) form of age-related macular degeneration (AMD) is a leading cause of vision loss characterized by macular retinal pigment epithelium (RPE) and the ensuing photoreceptor degeneration. cGAS-STING signaling is a key cytosolic DNA sensor system in innate immunity and have recently been shown promotes RPE degeneration. However, expression regulation and therapeutic potential of cGAS and STING are not explored in retina under dry AMD pathogenic conditions. Our analysis shows upregulatedSTINGRNA and increased chromatin accessibility aroundcGASandSTINGpromoters in macular retinas from dry AMD patients. cGAS-STING activation was detected in oxidative stress-induced mouse retina degeneration, accompanied with cytosolic leakage of damaged DNA in photoreceptors. Pharmaceutical or genetic approaches indicates STING promotes retina inflammation and degeneration upon oxidative damage. Drug screening reveals that BRD4 inhibitor JQ1 reduces cGAS-STING activation, inflammation and photoreceptor degeneration in the injured retina. BRD4 inhibition epigenetically suppressesSTINGtranscription, and promotes autophagy-dependent cytosolic DNA clearance. Together, our results show that activation of cGAS-STING in retina may present pivotal innate immunity response in GA pathogenesis, whereas inhibition of cGAS-STING signaling by JQ1 could serve as a potential therapeutic strategy.
Fibroblast growth factor 20 attenuates pathological cardiac hypertrophy by activating the SIRT1 signaling pathway
Authors: Chen Yunjie , An Ning , Zhou Xuan , Mei Lin , Sui Yanru , Chen Gen , Chen Huinan , He Shengqu , Jin Cheng , Hu Zhicheng , Li Wanqian , Wang Yang , Lin Zhu , Chen Peng , Jin Litai , Guan Xueqiang , Wang Xu 
Published: March 2022

AbstractCardiac hypertrophy occurs initially in response to an increased cardiac load as a compensatory mechanism to maintain cardiac output. However, sustained pathological hypertrophy can develop into heart failure and cause sudden death. Fibroblast growth factor 20 (FGF20) is a member of the fibroblast growth factor family, which involved in apoptosis, aging, inflammation, and autophagy. The precise function of FGF20 in pathological cardiac hypertrophy is unclear. In this study, we demonstrated that FGF20 was significantly decreased in response to hypertrophic stimulation. In contrast, overexpression of FGF20 protected against pressure overload-induced cardiac hypertrophy. Mechanistically, we found that FGF20 upregulates SIRT1 expression, causing deacetylation of FOXO1; this effect promotes the transcription of downstream antioxidant genes, thus inhibits oxidative stress. In content, the anti-hypertrophic effect of FGF20 was largely counteracted in SIRT1-knockout mice, accompanied by an increase in oxidative stress. In summary, our findings reveal a previously unknown protective effect of FGF20 on pathological cardiac hypertrophy by reducing oxidative stress through activation of the SIRT1 signaling pathway. FGF20 is a potential novel molecular target for preventing and treating pressure overload-induced myocardial injury.
The impact of pre-existing hypertension and its treatment on outcomes in patients admitted to hospital with COVID-19
Authors: McFarlane Ewan , Linschoten Marijke , Asselbergs Folkert W. , Lacy Peter S. , Jedrzejewski Dawid , Williams Bryan ,   on Behalf of the CAPACITY-COVID Consortium
Published: March 2022

AbstractThe impact of pre-existing hypertension on outcomes in patients with the novel corona virus (SARS-CoV-2) remains controversial. To address this, we examined the impact of pre-existing hypertension and its treatment on in-hospital mortality in patients admitted to hospital with Covid-19. Using the CAPACITY-COVID patient registry we examined the impact of pre-existing hypertension and guideline-recommended treatments for hypertension on in-hospital mortality in unadjusted and multi-variate-adjusted analyses using logistic regression. Data from 9197 hospitalised patients with Covid-19 (median age 69 [IQR 57–78] years, 60.6% male, n = 5573) was analysed. Of these, 48.3% (n = 4443) had documented pre-existing hypertension. Patients with pre-existing hypertension were older (73 vs. 62 years, p < 0.001) and had twice the occurrence of any cardiac disease (49.3 vs. 21.8%; p < 0.001) when compared to patients without hypertension. The most documented class of anti-hypertensive drugs were angiotensin receptor blockers (ARB) or angiotensin converting enzyme inhibitors (ACEi) (n = 2499, 27.2%). In-hospital mortality occurred in (n = 2020, 22.0%), with more deaths occurring in those with pre-existing hypertension (26.0 vs. 18.2%, p < 0.001). Pre-existing hypertension was associated with in-hospital mortality in unadjusted analyses (OR 1.57, 95% CI 1.42,1.74), no significant association was found following multivariable adjustment for age and other hypertension-related covariates (OR 0.97, 95% CI 0.87,1.10). Use of ACEi or ARB tended to have a protective effect for in-hospital mortality in fully adjusted models (OR 0.88, 95% CI 0.78,0.99). After appropriate adjustment for confounding, pre-existing hypertension, or treatment for hypertension, does not independently confer an increased risk of in-hospital mortality patients hospitalized with Covid-19.
Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer
Authors: Gogleva Anna , Polychronopoulos Dimitris , Pfeifer Matthias , Poroshin Vladimir , Ughetto Michaël , Martin Matthew J. , Thorpe Hannah , Bornot Aurelie , Smith Paul D. , Sidders Ben , Dry Jonathan R. , Ahdesmäki Miika , McDermott Ultan , Papa Eliseo , Bulusu Krishna C. 
Published: March 2022

AbstractResistance to EGFR inhibitors (EGFRi) presents a major obstacle in treating non-small cell lung cancer (NSCLC). One of the most exciting new ways to find potential resistance markers involves running functional genetic screens, such as CRISPR, followed by manual triage of significantly enriched genes. This triage process to identify ‘high value’ hits resulting from the CRISPR screen involves manual curation that requires specialized knowledge and can take even experts several months to comprehensively complete. To find key drivers of resistance faster we build a recommendation system on top of a heterogeneous biomedical knowledge graph integrating pre-clinical, clinical, and literature evidence. The recommender system ranks genes based on trade-offs between diverse types of evidence linking them to potential mechanisms of EGFRi resistance. This unbiased approach identifies 57 resistance markers from >3,000 genes, reducing hit identification time from months to minutes. In addition to reproducing known resistance markers, our method identifies previously unexplored resistance mechanisms that we prospectively validate.
The phytochrome interacting proteins ERF55 and ERF58 repress light-induced seed germination in Arabidopsis thaliana
Authors: Li Zenglin , Sheerin David J. , von Roepenack-Lahaye Edda , Stahl Mark , Hiltbrunner Andreas 
Published: March 2022

AbstractSeed germination is a critical step in the life cycle of plants controlled by the phytohormones abscisic acid (ABA) and gibberellin (GA), and by phytochromes, an important class of photoreceptors in plants. Here we show that light-dependent germination is enhanced in mutants deficient in the AP2/ERF transcription factors ERF55 and ERF58. Light-activated phytochromes repress ERF55/ERF58 expression and directly bind ERF55/ERF58 to displace them from the promoter of PIF1 and SOM, genes encoding transcriptional regulators that prevent the completion of germination. The same mechanism controls the expression of genes that encode ABA or GA metabolic enzymes to decrease levels of ABA and possibly increase levels of GA. Interestingly, ERF55 and ERF58 are themselves under transcriptional control of ABA and GA, suggesting that they are part of a self-reinforcing signalling loop which controls the completion of germination. Overall, we identified a role of ERF55/ERF58 in phytochrome-mediated regulation of germination completion.
A mathematical analysis of an extended MHD Darcy–Forchheimer type fluid
Authors: Díaz Palencia José Luis 
Published: March 2022

AbstractThe presented analysis has the aim of introducing general properties of solutions to an Extended Darcy–Forchheimer flow. The Extended Darcy–Forchheimer set of equations are introduced based on mathematical principles. Firstly, the diffusion is formulated with a non-homogeneous operator, and is supported by the addition of a non-linear advection together with a non-uniform reaction term. The involved analysis is given in generalized Hilbert–Sobolev spaces to account for regularity, existence and uniqueness of solutions supported by the semi-group theory. Afterwards, oscillating patterns of Travelling wave solutions are analyzed inspired by a set of Lemmas focused on solutions instability. Based on this, the Geometric Perturbation Theory provides linearized flows for which the eigenvalues are provided in an homotopy representation, and hence, any exponential bundles of solutions by direct linear combination. In addition, a numerical exploration is developed to find exact Travelling waves profiles and to study zones where solutions are positive. It is shown that, in general, solutions are oscillating in the proximity of the null critical state. In addition, an inner region (inner as a contrast to an outer region where solutions oscillate) of positive solutions is shown to hold locally in time.