bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involvement of Multiple Variants of Soluble CD146 in Systemic Sclerosis: Identification of a Novel Profibrotic Factor
Authors: Nollet Marie , Bachelier Richard , Joshkon Ahmad , Traboulsi Waël , Mahieux Amandine , Moyon Anais , Muller Alexandre , Somasundaram Indumathi , Simoncini Stéphanie , Peiretti Franck , Leroyer Aurélie S. , Guillet Benjamin , Granel Brigitte , Dignat‐George Françoise , Bardin Nathalie , Foucault‐Bertaud Alexandrine , Blot‐Chabaud Marcel 
Published: January 2022

ObjectiveSystemic sclerosis (SSc) is an autoimmune disorder characterized by excessive fibrosis, immune dysfunction, and vascular damage, in which the expression of many growth factors is deregulated. CD146 was recently described as a major actor in SSc. Since CD146 also exists as a circulating soluble form (sCD146) that acts as a growth factor in numerous angiogenic‐ and inflammation‐related pathologies, we sought to identify the mechanisms underlying the generation of sCD146 and to characterize the regulation and functions of the different variants identified in SSc.MethodsWe performed in vitro experiments, including RNA‐Seq and antibody arrays, and in vivo experiments using animal models of bleomycin‐induced SSc and hind limb ischemia.ResultsMultiple forms of sCD146, generated by both shedding and alternative splicing of the primary transcript, were discovered. The shed form of sCD146 was generated from the cleavage of both long and short membrane isoforms of CD146 through ADAM‐10 and TACE metalloproteinases, respectively. In addition, 2 novel sCD146 splice variants, I5‐13‐sCD146 and I10‐sCD146, were identified. Of interest, I5‐13‐sCD146 was significantly increased in the sera of SSc patients (P < 0.001; n = 117), in particular in patients with pulmonary fibrosis (P < 0.01; n = 112), whereas I10‐sCD146 was decreased (P < 0.05; n = 117). Further experiments revealed that shed sCD146 and I10‐sCD146 displayed proangiogenic activity through the focal adhesion kinase and protein kinase Cε signaling pathways, respectively, whereas I5‐13‐sCD146 displayed profibrotic effects through the Wnt‐1/β‐catenin/WISP‐1 pathway.ConclusionVariants of sCD146, and in particular the novel I5‐13‐sCD146 splice variant, could constitute novel biomarkers and/or molecular targets for the diagnosis and treatment of SSc and other angiogenesis‐ or fibrosis‐related disorders.
Bright spectroscopic binaries: II. A study of five systems with orbital periods of days
Authors: Jack Dennis , Hernández Huerta Missael Alejandro , Rosas‐Portilla Faiber Danilo , Schröder Klaus‐Peter 
Published: January 2022

AbstractWe present a detailed analysis of five bright spectroscopic binary systems (HD 18665, HD 27131, HD 171852, HD 215550, and HD 217427) that have orbital periods of days. We determined the complete set of orbital parameters using the toolkit RadVel by analyzing the observed radial velocity curves. To study the properties of the five systems, we also analyzed the intermediate resolution spectra () observed with the Telescopio Internacional de Guanajuato Robótico Espectroscópico (TIGRE) telescope and determined the stellar parameters of the primary stars using the toolkit iSpec. With Gaia Early Data Release 3 parallaxes, a correction for interstellar extinction using the 3D dust map, and bolometric corrections, we placed the stars in the Hertzsprung‐Russell diagram and compared the positions with stellar evolution tracks calculated with the Eggleton code to determine the masses and ages of the primary stars. They have all evolved to the giant phase. Finally, we were able to determine the masses of the secondary stars and to estimate the orbital inclinations of the binary systems.
Computational Screening of Anode Coatings for Garnet‐Type Solid‐State Batteries
Authors: Liu Chencheng , Früchtl Herbert , Irvine John T. S. , Bühl Michael 
Published: January 2022

AbstractMaking use of a large materials database of DFT‐derived structures and energies, we applied a high‐throughput computational screening framework to identify lithium‐containing oxides as potential anode coatings for lithium (Li) garnet. A preselection of candidate materials was made based on their phase stability, electrochemical stability, and chemical stability, as emerging from this database. Then first‐principles calculations (periodic DFT calculations at the PBE level) were performed to further evaluate the Li‐ion conductivity and Li wettability of these coatings. A total of 10 Li−M−O compounds (Li3BO3, LiAlO2, Li5AlO4, Li4SiO4, Li8SiO6, Li4TiO4, Li8TiO6, Li6Zr2O7, Li2HfO3 and Li6Hf2O7) were identified as the most promising anode coatings. According to our findings, lithium concentration can affect the desired electrochemical stability and Li wettability in an opposing way. Compounds with high Li content tend to have low reduction potential with poor lithium wettability. Target materials may have a “sweet spot” in terms of Li content, where all key properties are balanced in an optimal way.
Profiling of widely targeted metabolomics for the identification of chemical composition in epidermis, xylem and pith of Gleditsiae Spina
Authors: Ya Huiyuan , Li Huiru , Liu Xianghui , Chen Ye , Zhang Jingxiao , Xie Yanfu , Wang Mengshu , Xie Wanyue , Li Shipeng 
Published: January 2022

AbstractGleditsiae Spina, the thorn of Gleditsia sinensis Lam., has a long history of being used as a traditional medicine in East Asian countries. However, only a few biologically active substances have been identified from it. In this study, the epidermis, xylem and pith of Gleditsiae Spina, respectively Gs‐E, Gs‐X and Gs‐P, were studied. We used a widely targeted metabolomics method to investigate the chemical composition of Gs‐E, Gs‐X and Gs‐P. A total of 728 putative metabolites were identified from Gleditsiae Spina, including 211 primary metabolites and 517 secondary metabolites. These primary and secondary metabolites could be categorized into more than 10 different classes. Flavonoids, phenolic acids, lipids, amino acids and derivatives, and organic acids constituted the main metabolite groups. Multivariate statistical analysis showed that the Gs‐E, Gs‐X and Gs‐P samples could be clearly separated. Differential accumulated metabolite (DAM) analysis revealed that more than half of the DAMs exhibited the highest relative concentrations in Gs‐E, and most of the DAMs showed the lowest relative concentrations in Gs‐X. Moreover, 11 common differential primary metabolites and 79 common differential secondary metabolites were detected in all comparison groups. These results further our understanding of chemical composition and metabolite accumulation of Gleditsiae Spina.
Redox‐mediated proton transport of two‐dimensional polyaniline‐based nanochannels for fast capacitive performance
Authors: Yu Mengying , Liu Huabo , Xiao Kefeng , Xie Bingqiao , Han Zhaojun , Wang Da‐Wei 
Published: January 2022

AbstractTwo‐dimensional (2D) materials are being increasingly exploited for ion transport and storage under nanoconfinement. Here we demonstrate distinct ion transport behavior upon potential‐induced redox reaction in 2D tungstate anion cross‐linked polyaniline (TALP) electrode. It is found that, in the neutral electrolyte, SO42− ion serves as the main charge carrier in 2D polyaniline backbone when the electrical double layer charging dominates. While in an acidic electrolyte, proton transport in TALP turns to be the dominant ion behavior that is associated with the proton‐promoting surface redox processes. Moreover, higher capacitance along with better capacitive retention at a high rate is also demonstrated for TALP electrode in acidic electrolyte compared with that in the neutral environment. The results show that 2D nanoionics can be manipulated by applying redox‐active materials to build the nanochannels that allow the regulation of surface charge and chemistry with potential‐specific redox reactions.
High‐performance Li‐ion capacitor via anion‐intercalation process
Authors: Rajalekshmi Ambika Rajendran , Divya Madhusoodhanan Lathika , Lee Yun‐Sung , Aravindan Vanchiappan 
Published: January 2022

AbstractSupercapacitors are characterized by their fast charge/discharge capability, high‐power capability, and long cycle life, but low‐energy‐density impedes their practical application. The requirement of achieving a highly efficient energy storage system demands the hybridization of supercapacitors and batteries. The anion‐intercalation chemistry of graphite with high insertion potential creates a possibility of using graphite as a cathode, which works as an acceptor‐type graphite intercalation compound. Herein, we report the reversible PF6– anion storage on the graphite cathode, which occurs by the combination of pseudocapacitive and diffusion‐limited redox reaction at a higher working potential. Furthermore, a dual carbon lithium‐ion capacitor (LIC) using commercial graphite as anion‐intercalation type, battery type cathode, and commercial‐activated carbon (AC) as supercapacitor type anode is designed. The assembled preanion intercalated Graphite/AC‐based LIC assembly displayed a high‐energy density of 90.73 Wh kg–1. Moreover, the device with low‐temperature stability is advantageous over traditional electrical double‐layer capacitors, mainly in terms of its energy and low cost with much more safety features than commercial lithium‐ion batteries.
Virtual body anthropomorphism increases drift in self‐location: Further support for the humanoid shape rule
Authors: Tekgün Ege , Uludağlı Muhtar Ç. , Akcan Hüseyin , Erdeniz Burak 
Published: January 2022

AbstractPrevious studies on bodily self‐consciousness (BCS) have shown that self‐location and body ownership are prone to changes based on the perceptual appearances of the fake virtual body. In the current study with 36 participants, we assessed the influence of virtual avatar anthropomorphism and the synchronicity of the visuo‐tactile stimulation on self‐location using a virtual reality full‐body illusion experiment. During the experiment, half of the participants observed a gender‐matched full‐body humanoid avatar from a first‐person perspective (1PP) and the other half observed a less anthropomorphic full‐body cubical avatar from 1PP while they were receiving synchronous and asynchronous visuo‐tactile stimulation. Results showed a significant main effect of the synchronicity of the visuo‐tactile stimulation and avatar body type on self‐location but no significant interaction was found between them. Moreover, the results of the self‐report questionnaire provide additional evidence showing that participants who received synchronous visuo‐tactile stimulation, experienced not only greater changes in the feeling of self‐location, but also, increased ownership, and referral of touch. Our results provided further support for the previous findings that showed evidence for the effect of virtual avatar appearance on BCS.
Comparative studies on physicochemical properties of gluten‐ and glutenin‐based films functionalized by polyphenols
Authors: Liu Xinye , Xie Yuran , Li Chen , Xue Feng 
Published: January 2022

AbstractBackground and objectivesThis study aimed to develop gluten‐ and glutenin‐based active films functionalized individually by three different types of polyphenols (naringin, cyanidin‐3‐O‐glucoside, and proanthocyanidin). The interaction of these phenolic compounds with gluten and glutenin, and the effect of presence of these polyphenols on the physicochemical, antioxidative, and antimicrobial properties of resulting films were evaluated.Findings.The proanthocyanidin interacted with gluten and glutenin helped to form rougher surface structure and more homogeneous cross‐sectional structure. Therefore, the water vapor barrier property, water repellence, tensile strength, and thermal stability of the films were substantially improved in the presence of proanthocyanidin. The films containing proanthocyanidin also showed ability to inhibit growth of foodborne pathogens and scavenge free radical. Furthermore, the glutenin films exhibited higher tensile strength and better thermal stability. The gluten films possessed better water vapor barrier property and water repellence.ConclusionThere were significant differences in physical properties between gluten films and glutenin films due to the difference of composition. However, the effects of polyphenols on the physical properties of the two films were basically the same.Significanceand novelty.The differences in physicochemical properties between gluten‐ and glutenin‐based films functionalized by polyphenols were illustrated in this study.
Syntheses, Polymorphic Transformations, and Functions of Ionic Crystals Based on Mononuclear Bismuth(III) Complexes and Polyoxometalates
Authors: Iwano Tsukasa , Akutsu Daiki , Weng Zhewei , Ogiwara Naoki , Uchida Sayaka 
Published: January 2022

AbstractThe controlled assembly of molecules, ions, and ligands as building blocks based on crystal engineering leads to various functional crystalline solids. In particular, polyoxometalates (POMs), which are anionic metal oxide clusters, have been a popular motif in crystal engineering. To revisit simple mononuclear metal complexes as counter cations of POMs, seven ionic crystals based on Keggin‐ or Dawson‐type POMs with mononuclear bismuth(III) complexes as counter cations were synthesized. The bismuth(III) center exhibited triangular dodecahedron, square antiprism, or pseudo‐cubic eight‐coordination geometries, with dimethyl sulfoxide or N,N‐dimethylformamide as ligands. The ionic crystals showed polymorphic transformation depending on the synthetic or recrystallization conditions. As a method for exploring functionality, proton conductivities of the ionic crystals were measured under humidified conditions. The ionic crystals with high porosity, tertiary amine moieties, or coordination water exhibited high proton conductivities, and large activation energies indicate that protons are transferred mainly with water molecules via the vehicle mechanism.
Propagation of errors in a color matching experiment
Authors: Carreño Fernando 
Published: January 2022

AbstractWe revisit the problem of propagation of errors in the color matching experiment reported by MacAdam [J. Opt. Soc. Am. 32, 247 (1942)]. The observer made color matchings by tuning the angle of a Rochon prism. The average value and the standard deviations of the angle settings were considered to derive the average tristimulus values and the uncertainty intervals. Here, we use a rigorous statistical method to derive the probability density functions of the tristimulus values assuming a Gaussian distribution for the Rochon prism angle. We analyze how much the actual probability density functions deviate from the Gaussian. We outline two methods to derive the interval of color mismatch and compare their predictions with those derived using the standard procedure.
Dyscalculia and dyslexia in Chinese children with idiopathic epilepsy: Different patterns of prevalence, comorbidity, and gender differences
Authors: Cheng Dazhi , Miao Xinyang , Wu Haiyan , Chen Chuansheng , Chen Qian , Zhou Xinlin 
Published: January 2022

AbstractObjectiveThe present study aimed to examine the prevalence of dyscalculia, dyslexia, and their comorbidity rates in a large population‐based sample of children with idiopathic epilepsy (N = 2282) and a comparison sample of typically developing schoolchildren (N = 2371).MethodsBoth groups of children were screened using an arithmetic fluency test for dyscalculia and a reading fluency test for dyslexia. Their comorbidity rates were assessed. The prevalence rates of dyscalculia, dyslexia, comorbidity, and isolated dyscalculia/dyslexia (ie, participants with comorbid dyslexia and dyscalculia were excluded) were analyzed.ResultsIn both −1.5 SD and −1 SD cutoff criterion, the prevalence rates were about two times higher in children with idiopathic epilepsy than in other schoolchildren; the prevalence rates of isolated dyslexia were higher in children with idiopathic epilepsy than in other schoolchildren (−1 SD: 10.9% vs 8.6%; −1.5 SD: 6.5% vs 4.7%). Meanwhile, comorbidity rates of dyscalculia and dyslexia were higher in children with idiopathic epilepsy than in other schoolchildren (32.7% vs 26.6%; 38.3% vs 23.5%, respectively). Overall, patterns of prevalence rates were different for children with idiopathic epilepsy and schoolchildren, in which children with idiopathic epilepsy had a higher prevalence rate of dyscalculia than dyslexia, while schoolchildren had a higher prevalence of dyslexia than dyscalculia, regardless of cutoff criteria. Interestingly, gender differences in the prevalence rates of all types of learning disabilities were found in schoolchildren, but there were only gender differences in the prevalence rates of dyslexia in children with idiopathic epilepsy.SignificanceThe results highlight the vulnerability of children with idiopathic epilepsy for learning disabilities and a differential pattern of gender differences in dyslexia. Moreover, different patterns of prevalence rates suggest that children with idiopathic epilepsy and schoolchildren are more prone to different types of learning disabilities. The findings suggest needs for special interventions of learning disabilities for children with idiopathic epilepsy.
Decommissioned batteries and their usage in multilevel inverters as an addition to the circular economy
Authors: Hamid Muhammad , Li Boyang , Xie Jian 
Published: January 2022

AbstractResearch on decommissioned batteries emphasizes the value of lost energy in batteries. This article analyzes the leftover battery capacity after its decommissioning from electric vehicles. This analysis includes the discreteness of the battery capacity, sorting based on a QC/T‐standard and alteration among the battery capacities. The potential of decommissioned batteries in other applications is presented, and a roadmap for the circular economy is suggested. Based on the data collected in China, significant faults occurring inside electric vehicles' battery packs are reviewed. An alternative inverter is tested to solve the significant challenges in using decommissioned batteries. Advancements are made toward a new intuitive cell balancing technique to utilize maximum capacity in each cell.
Managing Freshwater Fish in a Changing Climate: Resist, Accept, or Direct
Authors: Rahel Frank J 
Published: January 2022

Abstract
Climate change is altering the distribution, phenology (e.g., timing of spawning), and community dynamics of freshwater fishes. Managers have three options for responding to these changes: “Resist” change to maintain or restore historic abiotic and biological conditions; “Accept” change and manage within the new conditions; or “Direct” change to produce new conditions considered desirable by humans. I discuss how the inland fisheries management approaches of stocking, regulations, habitat improvement, and community manipulations can be applied within the Resist-Accept-Direct (RAD) framework. I also discuss ways to choose among these options and how ecological tipping points can be used to determine when Resist is no longer a feasible option and managers must shift to Accept or Direct options.
MHD slip flow and heat transfer of UCM fluid with the effect of suction/injection due to stretching sheet: OHAM solution
Authors: Guled C. N. , Tawade J. V. , Nandeppanavar Mahantesh M. , Saraf A. R. 
Published: January 2022

AbstractIn this study, the optimal homotopy analysis (OHAM) technique has been examined to solve the laminar magnetohydrodynamic flow (MHD flow) on the upper‐convected Maxwell fluid on an isothermal porous stretch surface. A study on the effects of parameters like the relaxation time, suction/injection velocity, as well as the magnetic number on velocity over a sheet was conducted and these results are compared to the corresponding previously available results. It was observed that the thickness of the boundary layer is lowered by enhancing , , and values. Opposing this, it was observed that large values increase the magnituIIde. It is found that OHAM is an efficient method capable of giving a greater degree of accuracy in numerical values of flow parameters even after fewer approximations.
Dyserythropoietic anaemia with an intronic GATA1 splicing mutation in patients suspected to have Diamond‐Blackfan anaemia
Authors: Kobayashi Akie , Ohtaka Ryusei , Toki Tsutomu , Hara Junichi , Muramatsu Hideki , Kanezaki Rika , Takahashi Yuka , Sato Tomohiko , Kamio Takuya , Kudo Ko , Sasaki Shinya , Yoshida Taro , Utsugisawa Taiju , Kanno Hitoshi , Yoshida Kenichi , Nannya Yasuhito , Takahashi Yoshiyuki , Kojima Seiji , Miyano Satoru , Ogawa Seishi , Terui Kiminori , Ito Etsuro 
Published: January 2022

AbstractDiamond‐Blackfan anaemia (DBA) shares clinical features with two recently reported sporadic cases of dyserythropoietic anaemia with a cryptic GATA1 splicing mutation (c.871‐24 C>T). We hypothesized that some patients clinically diagnosed with DBA but whose causative genes were unknown may carry the intronic GATA1 mutation. Here, we examined 79 patients in our DBA cohort, who had no detectable causative genes. The intronic GATA1 mutation was identified in two male patients sharing the same pedigree that included multiple cases with anaemia. Cosegregation of this mutation and disease in multiple family members provide evidence to support the pathogenicity of the intronic GATA1 mutation.
Very long‐chain acyl‐CoA dehydrogenase deficiency in a Swedish cohort: Clinical symptoms, newborn screening, enzyme activity, and genetics
Authors: Olsson David , Barbaro Michela , Haglind Charlotte , Halldin Maria , Lajic Svetlana , Tucci Sara , Zetterström Rolf H. , Nordenström Anna 
Published: January 2022

AbstractVery long‐chain acyl‐CoA dehydrogenase deficiency (VLCADD) is a recessive disorder of fatty acid beta‐oxidation with variable phenotype. Patients may present during the neonatal period with lethal multi‐organ failure or during adulthood with a myopathic phenotype. VLCADD is included in the Swedish newborn screening (NBS) program since 2010. The study describes the phenotype and biochemical findings in relation to the genotype, enzyme activity, and screening data in a Swedish cohort of pediatric patients with VLCADD. A total of 22 patients (20 diagnosed via NBS between 2010 and 2019, two diagnosed pre NBS) were included. Parameters analyzed were enzyme activity (palmitoyl CoA oxidation rate); ACADVL genotype; NBS results including Collaborative Laboratory Integrated Reports (CLIR) score; biochemical findings; treatment; clinical outcome. A clinical severity score (CSS) was compiled using treatment interventions and clinical symptoms. A possible correlation between CSS and VLCAD residual enzyme activity and NBS CLIR score was analyzed. The most common ACADVL variant (c.848T>C) was identified in 24/44 alleles. Five novel variants were detected. Clinical manifestations varied from asymptomatic to severe. There was a correlation between CSS, residual enzyme activity, and CLIR scores. Most patients diagnosed via NBS had less severe disease compared to those clinically diagnosed. In conclusion, the identified correlation between the NBS CLIR score, residual enzyme activity, and clinical outcome suggests that information available neonatally may aid in treatment decisions.