bluuebunny/crossref_metadata_2025_split huggingface dataset:
MANAJEMEN BALANCE SCORECARD DALAM MENINGKATKAN MUTU PENDIDIKAN DI KB MUSLIMAT NU NUR IKHLAS DESA BOJONGSANA KECAMATAN SURADADI KABUPATEN TEGAL
Authors: . Muksin 
Published: March 2022

Manajemen balance scorecard dapat membantu proses pendidikan yang memuat sistem manajemen peningkatan mutu berkelanjutan dan dengan keseimbangan pengelolaan disetiap unit. Dalam Penerapannya di dunia pendidikan mempunyai empat perspektif, perspektif keuangan, pelanggan, proses, dan pembelajaran / pertumbuhan. Sehingga perlu dikaji dan diadakan penelitian (research), tentang manajemen balance scorecard sekolah dalam meningkatkan mutu pendidikan khususnya di Kelompok Belajar (KB). Penelitian ini bertujuan untuk mendeskripsikan dan menjelaskan (explanatory) manajemen BSC yang dilaksanakan oleh KB Muslimat NU Nur Ikhlas, termasuk di dalamnya mendeskripsikan sumber-sumber pendukung yang dimanfaatkan untuk meningkatkan mutu pendidikan. Penelitian ini merupakan penelitian kualitatif. Pengumpulan data menggunakan wawancara, observasi, dan dokumentasi, dan keabsahan data menggunakan triangulasi, dan teknik analisis data meliputi pegumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil Penelitian menunjukkan bahwa dari segi mutu pendidikan yang diraih KB Muslimat NU Nur Ikhlas relatif lebih baik untuk tingkat PAUD yang belum lama berdiri. (1) Perspektif Balanced ScoreCard yang diterapkan untuk organisasi/lembaga non profit seperti di KB Muslimat NU Nur Ikhlas ini mengharuskan untuk dimodifikasi. Jika pada organisasi profit untuk perspektif finansial adalah kas masuk dan modal kerja, maka untuk organisasi non profit fokus utama bukan pada pencapaian finansial, tetapi pada pencapaian tujuan yang terfokus pada pelanggan, dalam konteks organisasi pemerintah adalah masyarakat, maka layanan publik harus diberikan pada tingkat biaya yang kompetitif dan efisien. (2) Dalam dunia usaha, apapun usahanya termasuk usaha dalam jasa pendidikan yaitu Kelompok Belajar (KB), agar sukses dalam usahanya maka harus memberikan kepuasan kepada pelanggannya, baik pelanggan internal maupun pelanggan eksternal. (3) Kemampuan mendidik dan melatih yang dimiliki guru berbeda-beda sehingga diperlukan satu upaya untuk membantu para guru dalam menemukan strategi dan metode yang pas dalam pembelajaran sehingga dapat menjamin perbaikan mutu dan memecahkan persoalan pembelajaran masing-masing. (4) Dari perspektif pembelajaran dan pertumbuhan dengan tujuan strategi mengembangkan kreativitas guru untuk mengembangkan metode pembelajaran yang berkualitas dan terjangkau dapat diukur dengan meningkatnya kreativitas guru dan bervariasinya metode yang digunakan dalam pembelajaran (outcome), serta dilihat dari rasio murid: guru serta rasio alat peraga : murid.(pengendalian mutu).
PENYULUHAN PENGELOLAAN SAMPAH DENGAN KONSEP 3R DALAM MENGURANGI LIMBAH RUMAH TANGGA
Authors: Ristya Trisnawati Oky 
Published: March 2022

Sampah menjadi salah satu permasalahan yang cukup sulit di tangani di Indonesia. Keberadaan limbah rumah tangga (sampah) yang dihasilkan akibat aktivitas manusia mempunyai banyak dampak pada manusia dan lingkungan sekitar. Masih banyak ditemukan sampah organik dan anorganik yang dihasilkan oleh aktivitas masyarakat di lingkungan sekitar pemukiman warga Desa Kebadongan yang bersumber dari aktifitas rumah tangga. Pelaksanaan penyuluhan dan pemberian pelatihan pengelolaan dan pemanfaatan sampah menggunakan konsep 3R (Reduce, Reuse, Recycle) atau pengurangan, penggunaan kembali dan mendaur ulang sampah adalah salah satu cara yang efektif untuk dapat menciptakan suatu kawasan dengan tingkat pengelolaan sampah mandiri yang akan membantu pemerintah untuk menciptakan lingkungan yang sehat, bersih dan nyaman. Penelitian ini dilakukan dengan tujuan untuk: (1) memberikan pengetahuan kepada masyakat tentang pentingnya memilah sampah organik dan anorganik sebagai kunci awal penerapan konsep 3R dan (2) memberikan pengetahuan kepada masyarakat dalam pengolahan sampah organik menjadi pupuk kompos dan pengolahan sampah anorganik menjadi berbagai jenis kerajinan tangan. Kegiatan penelitian ini dilakukan di Desa Kebadongan pada hari Minggu tanggal 20 Januari 2019 pukul 11.00 bertempat di aula balaidesa dengan menggunakan metode ceramah, demonstrasi dan diskusi. Pelaksanaan kegiatan penelitian dapat diuraikan melalui 3 (tiga) tahapan kegiatan, yaitu persiapan, pelaksanaan dan evaluasi. Hasil nyata yang didapatkan dari kegiatan penyuluhan dan pelatihan pengelolaan sampah menggunakan konsep 3R ini adalah meningkatnya pengetahuan masyarakat tentang sampah. Masyarakat juga menyadari dan mulai membiasakan diri untuk memilah sampah organik dan anorganik sebagai kunci awal penerapan konsep 3R. Penggunaan konsep 3R (reuse, reduce, recycle) dapat menginspirasi warga untuk menciptakan suatu kawasan dengan tingkat pengelolaan sampah mandiri yang akan membantu pemerintah untuk menciptakan lingkungan yang sehat, bersih dan nyaman. Selain itu, pengetahuan masyarakat tentang pengelolaan sampah organik dan anorganik juga semakin meningkat.
MicroRNA-194-5p Attenuates Doxorubicin-Induced Cardiomyocyte Apoptosis and Endoplasmic Reticulum Stress by Targeting P21-Activated Kinase 2
Authors: Fa Hongge , Xiao Dandan , Chang Wenguang , Ding Lin , Yang Lanting , Wang Yu , Wang Mengyu , Wang Jianxun 
Published: March 2022

ObjectiveMany studies have reported that microRNAs (miRs) are involved in the regulation of doxorubicin (DOX)-induced cardiotoxicity. MiR-194-5p has been reported significantly upregulated in patients with myocardial infarction; however, its role in myocardial diseases is still unclear. Various stimuluses can trigger the endoplasmic reticulum (ER) stress and it may activate the apoptosis signals eventually. This study aims to explore the regulatory role of miR-194-5p in DOX-induced ER stress and cardiomyocyte apoptosis.MethodsH9c2 was treated with 2 μM DOX to induce apoptosis, which is to stimulate the DOX-induced cardiotoxicity model. The expression of miR-194-5p was detected by quantitative real-time PCR (qRT-PCR); the interaction between miR-194-5p and P21-activated kinase 2 (PAK2) was tested by dual luciferase reporter assay; terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay and caspase-3/7 activity were used to assess apoptosis; trypan blue staining was applied to measure cell death; Western blotting was performed to detect protein expressions; and ER-related factors splicing X-box binding protein 1 (XBP1s) was detected by polyacrylamide gel electrophoresis and immunofluorescence to verify the activation of ER stress.ResultsMiR-194-5p was upregulated in cardiomyocytes and mouse heart tissue with DOX treatment, while the protein level of PAK2 was downregulated. PAK2 was predicted as the target of miR-194-5p; hence, dual luciferase reporter assay indicated that miR-194-5p directly interacted with PAK2 and inhibited its expression. TUNEL assay, caspase-3/7 activity test, and trypan blue stain results showed that either inhibition of miR-194-5p or overexpression of PAK2 reduced DOX-induced cardiomyocyte apoptosis. Silencing of miR-194-5p also improved DOX-induced cardiac dysfunction. In addition, DOX could induce ER stress in H9c2, which led to XBP1 and caspase-12 activation. The expression level of XBP1s with DOX treatment increased first then decreased. Overexpression of XBP1s suppressed DOX-induced caspase-3/7 activity elevation as well as the expression of cleaved caspase-12, which protected cardiomyocyte from apoptosis. Additionally, the activation of XBP1s was regulated by miR-194-5p and PAK2.ConclusionOur findings revealed that silencing miR-194-5p could alleviate DOX-induced cardiotoxicity via PAK2 and XBP1s in vitro and in vivo. Thus, the novel miR-194-5p/PAK2/XBP1s axis might be the potential prevention/treatment targets for cancer patients receiving DOX treatment.
Association Between Non-Recovered Contrast-Associated Acute Kidney Injury and Poor Prognosis in Patients Undergoing Coronary Angiography
Authors: Zhou Dianhua , Lun Zhubin , Wang Bo , Liu Jin , Liu Liwei , Chen Guanzhong , Ying Ming , Li Huanqiang , Chen Shiqun , Tan Ning , Chen Jiyan , Liu Yong , Ye Jianfeng 
Published: March 2022

BackgroundPrevious studies have shown that renal function recovery after acute kidney injury (AKI) was associated with decreased risk of all-cause mortality. However, little is known about the correlation between renal function recovery and long-term prognosis in patients with contrast-associated acute kidney injury (CA-AKI) undergoing coronary angiography (CAG).MethodsWe retrospectively enrolled 5,865 patients who underwent CAG. CA-AKI was defined as an increase in serum creatinine (SCr) ≥ 50% or ≥ 0.3 mg/dl from baseline within 72 h post procedure. Recovered CA-AKI was defined as a decrease in SCr to baseline or no CA-AKI level. The first endpoint was long-term all-cause mortality. Kaplan–Meier analysis and Cox regression analysis were used to investigate the association between kidney function recovery and long-term mortality.ResultsDuring the median follow-up period of 5.25 years, the overall long-term mortality was 20.07%, and the long-term mortality in patients with recovered CA-AKI and non-recovered CA-AKI was 17.46 and 27.44%, respectively. After multivariate Cox hazard regression, non-recovered CA-AKI was significantly associated with long-term mortality, while recovered CA-AKI was not [recovered CA-AKI vs. no CA-AKI, hazard ratio (HR) = 1.06, 95% confidence interval (CI): 0.81–1.39, p = 0.661; non-recovered CA-AKI vs. no CA-AKI, HR = 1.39, 95% CI: 1.21–1.60, p &lt; 0.001]. In the subgroup of CAD, both recovered CA-AKI and non-recovered CA-AKI were associated with increased risk of long-term all-cause mortality. However, in other subgroup analyses, only non-recovered CA-AKI was associated with increased risk of long-term all-cause mortality.ConclusionOur results found that non-recovered CA-AKI is significantly associated with long-term mortality. In patients with CAD, recovered CA-AKI can still increase the risk of all-cause mortality. Clinicians need to pay more attention to patients suffering from CA-AKI, whose kidney function has not recovered. In addition, active prevention treatments should be taken by patients with CAD.
Relationship Between Serum Concentration of Adrenomedullin and Myocardial Ischemic T Wave Changes in Patients With Lung Cancer
Authors: Wu Chen , Lin Da-wei , Jiang Yi-wen , Jiang Feng , Wang Zhao-xia , Wang Yao-sheng 
Published: March 2022

BackgroundPatients with lung cancer are at increased risk for the development of cardiovascular diseases. Molecular markers for early diagnosis of cardiac ischemia are of great significance for the early prevention of cardiovascular events in patients with lung cancer. By evaluating the relationship between adrenomedullin (ADM) and myocardial ischemic T wave changes, the clinical value of circulating ADM as a predictor of myocardial ischemia in patients with lung cancer is confirmed.MethodsWe enrolled patients with lung cancer and healthy people from 2019 to 2021 and extracted a detailed ECG parameter. After adjustment for potential confounders, logistic regression was used to assess the association of clinical data. We performed analyses on differences in T wave between patients with lung cancer and healthy people, and the relationship between T wave and ADM among patients with lung cancer. Receiver operator characteristic (ROC) curves were drawn to confirm the diagnostic value of biomarkers.ResultsAfter adjusting for potential confounders, the incidence of T wave inversion or flattening in patients with lung cancer was higher than in healthy people (OR: 3.3228, P = 0.02). Also, further analysis of the data of lung cancer patients revealed that the ADM in lung cancer patients with T wave inversion or flat was higher than those with normal T wave (189.8 ± 51.9 vs. 131.9 ± 38.4, p &lt; 0.001). The area under the ROC curve was 0.8137.ConclusionAmong the patients with lung cancer, serum ADM concentration is associated with the incidence of the abnormal T wave. ADM might be a potentially valuable predictor for heart ischemia in patients with lung cancer.
The CSP (Cardiogenic Shock Prognosis) Score: A Tool for Risk Stratification of Cardiogenic Shock
Authors: Tien Yu-Tzu , Chen Wen-Jone , Huang Chien-Hua , Wang Chen-Hsu , Chen Wei-Ting , Hung Chi-Sheng , Lin Jr-Jiun , Huang Ching-Chang , Chang Wei-Tien , Tsai Min-Shan 
Published: March 2022

BackgroundCardiogenic shock (CS) is a critical condition and the leading cause of mortality after acute myocardial infarction (AMI). Scores that predict mortality have been established, but a patient's clinical course is often nonlinear. Thus, factors present during acute care management may be explored. This study intended to develop a risk-predictive model for patients with CS.MethodsIn this observational study, adult patients who received inotropic support at the Emergency Room (ER) from January 2017 to August 2020 and were admitted to the cardiac care unit (CCU) with a diagnosis of CS were enrolled in this study. Patients with out-of-hospital cardiac arrest, inotropic support for bradycardia, and survival &lt;24 h after ER arrival were excluded. A total of 311 patients were enrolled and categorized into derivation (n = 243) and validation (n = 68) cohorts.ResultsA history of coronary artery disease, multiple inotrope use, ejection fraction &lt;40%, lower hemoglobin concentration, longer cardiopulmonary resuscitation duration, albumin infusion, and renal replacement therapy were identified as independent prognostic factors for in-hospital mortality. The cardiogenic shock prognosis (CSP) score was established as a nomogram and three risk groups were identified: low-risk (score 115, 0% of mortality), medium-risk (score 116–209, 8.75% of mortality), and high-risk (score 210, 66.67% of mortality). The area-under-the-curve (AUC) of the CSP score was 0.941, and the discrimination value in the validation cohort was consistent (AUC = 0.813).ConclusionsThe CSP score represents a risk-predictive model for in-hospital mortality in patients with CS in acute care settings. Patients identified as the high-risk category may have a poor prognosis.
Effect Modification of Hyperuricemia, Cardiovascular Risk, and Age on Chronic Kidney Disease in China: A Cross-Sectional Study Based on the China Health and Nutrition Survey Cohort
Authors: Li Yang , Zhu Bowen , Xie Yeqing , Jin Shi , Zhou Weiran , Fang Yi , Ding Xiaoqiang 
Published: March 2022

IntroductionThe question of whether the increased burden of chronic kidney disease (CKD) is caused by the interaction of hyperuricemia and cardiovascular disease (CVD) risk factors or is accelerated by aging remains unresolved. The purpose of this study is to better understand the effect modification of hyperuricemia, cardiovascular risk, and age on CKD among the Chinese population.MethodsThis cross-sectional study of 8243 participants was derived from the China Health and Nutrition Survey (CHNS) in 2009. Inclusion criteria included age ≥18 years, non-pregnancy, and no history of high-protein diet prior to blood test. Demographics, comorbidities, health-related behaviors, and serum biomarkers were collected. Interaction association of hyperuricemia, CVD risk and age with CKD were analyzed using Logistic regression.ResultsCKD was detected in 359 (27.2%, 95% CI 24.8∼29.7%) of 1321 participants with hyperuricemia and 680 (9.8%, 95% CI 9.1∼10.5%) of 6,922 participants without hyperuricemia, and these patterns remained significant after controlling for age, gender, and Framingham risk score (adjusted odds ratio [aOR] 3.82, 95% CI 3.20∼4.57). We found a negative multiplicative interaction between hyperuricemia and CVD risk on CKD. The aOR in low-CVD risk groups was 5.51 (95% CI 4.03∼7.52), followed by medium-CVD risk groups (aOR: 3.64, 95% CI 2.61∼5.09) and high-CVD risk groups (aOR: 2.89, 95% CI 2.12∼3.96). CVD risk was less associated with CKD in hyperuricemia group (aOR: 0.92, 95% CI 0.68∼1.22) than in non-hyperuricemia group (aOR: 1.43, 95% CI 1.21∼1.70). Furthermore, hyperuricemia and age had a significant additive effect on CKD, with a synergy index of 2.26 (95% CI 1.45∼3.52). Coexisting with older age and hyperuricemia, the likelihood of developing CKD was higher than the sum of the two alone.ConclusionThe link between hyperuricemia and CKD begins at a young age and becomes stronger in the low CVD risk group. For young adults, early detection of hyperuricemia, routine CVD risk assessment, and timely intervention of modifiable factors are warranted.
First Farmers in the South China Coast: New Evidence From the Gancaoling Site of Guangdong Province
Authors: Deng Zhenhua , Huang Bixiong , Zhang Qianglu , Zhang Min 
Published: March 2022

The transformation from hunter-gathering to farming in the south China coast has always been a conspicuous topic, as its great significance for the understanding of crop dispersal and human migration into southern China and Southeast Asia. It has been primarily assumed that rice was the only crop cultivated by early farmers in this region since 5,000 cal. BP., but the reliability of this speculation remains ambiguous, owing to the lack of systematic evidence. Based on analysis of macroscopic plant remains and phytoliths, as well as AMS radiocarbon dating at the Gancaoling site in Guangdong province, this study demonstrates the emergence of agriculture in the south China coast could be dated back to as early as 4,800–4,600 cal. BP., with the cultivation of rice and foxtail millet. This subsistence strategy change was an integral part of a more comprehensive social transformation, which started a new era of local history. Moreover, this discovery also provides further evidence supporting the universality of mixed farming in southern China and shed new light on the study of agriculture southward dispersal. The crop package of rice and millets possibly spread into the south China coast from Jiangxi via the mountain areas and then into Mainland Southeast Asia by a maritime route along the coastal regions.
Consistently Low Levels of Osteocalcin From Late Pregnancy to Postpartum Are Related to Postpartum Abnormal Glucose Metabolism in GDM Patients
Authors: Gong Yujia , Li Na , Lai Mengyu , Fang Fang , Yang Jiaying , Kang Mei , Shen Tingting , Peng Yongde , Wang Yufan 
Published: March 2022

ObjectiveIncreasing evidence suggests that osteocalcin (OC), a marker of bone formation, plays an important role in glucose homoeostasis. Few studies have investigated the relationship between OC levels in gestational diabetes mellitus (GDM) patients and their postpartum glucose metabolism. This study evaluated the relationship between OC levels in late pregnancy, their longitudinal changes, and postpartum glucose metabolism among GDM patients.MeasuresSerum OC was measured in late pregnancy and the postpartum period for 721 GDM patients. All patients underwent a 75-g oral glucose tolerance test (OGTT) at 6–8 weeks postpartum. According to postpartum OGTT outcomes, patients were categorized into abnormal glucose metabolism (AGM) (n=255) and normal glucose tolerance (NGT) groups (n=466). Glucose metabolism-related indices were measured and calculated. Logistic regression analysis and linear mixed-effects model were used to assess the association between OC and postpartum AGM.ResultsIn late pregnancy, OC levels were lower in the AGM group than in the NGT group (13.93 ± 6.90 vs 15.33 ± 7.63 ng/ml, P=0.015). After delivery, OC levels increased in both groups. However, OC levels remained lower in the AGM group than in the NGT group (23.48 ± 7.84 vs 25.65 ± 8.37 ng/ml, P=0.001). Higher OC levels in late pregnancy were associated with decreased risk of progressing to postpartum AGM (OR:0.96, 95%CI:0.94–0.99). Linear mixed-effects analysis showed that postpartum AGM patients exhibited consistently lower OC levels than NGT group from late pregnancy to the postpartum period after adjustment for cofactors (β=-1.70, 95% CI: -2.78– -0.62). ConclusionsIn GDM patients, consistently low levels of OC from late pregnancy to postpartum were associated with increased postpartum AGM risk. The increase in serum OC may act as a protective factor to curb the progression of AGM at postpartum for GDM patients.
The Association Between Leucine and Diabetic Retinopathy in Different Genders: A Cross-Sectional Study in Chinese Patients With Type 2 Diabetes
Authors: Li Shen , Huang Bing , Liu Ming-Li , Cui Xue-Ting , Cao Yun-Feng , Gao Zheng-Nan 
Published: March 2022

ObjectiveTo explore the association between serum leucine (leu) and diabetic retinopathy (DR) in patients with type 2 diabetes (T2D) and then to analyze the influence of gender on the association.MethodThe electronic medical records of 1,149 T2D patients who met inclusion and exclusion criteria were retrieved from the Second Affiliated Hospital of Dalian Medical University and the First Affiliated Hospital of Jinzhou Medical University. Serum leu levels of all subjects were measured by liquid chromatography–mass spectrometry. Logistic regression was used to obtain the odds ratio (OR) and CI of leu–DR risk in multiple models. When using these models, restricted cubic spline (RCS) was used to test the potential non-linear relationship between multiple continuous independent variables, such as leu and DR (classification), and dependent variables. We also used the additive interaction method to evaluate the interaction effect between leu and gender on DR.ResultsLeu was a protective factor of DR [0.78 (0.66, 0.92)]. When gender was divided into male and female, the above relationship was statistically significant only in men [0.73 (0.58, 0.94)]. Three indicators of additive interaction—RERI, AP, and S—suggested that there is no interaction between gender and leu on the risk of DR.ConclusionsMale T2D patients with high leu levels may have a lower risk of DR.
Metformin Use in Relation to Clinical Outcomes and Hyperinflammatory Syndrome Among COVID-19 Patients With Type 2 Diabetes: A Propensity Score Analysis of a Territory-Wide Cohort
Authors: Wong Carlos K. H. , Lui David T. W. , Lui Angel Y. C. , Low Marshall C. H. , Kwok Ashley C. Y. , Lau Kristy T. K. , Au Ivan C. H. , Xiong Xi , Chung Matthew S. H. , Lau Eric H. Y. , Cowling Benjamin J. 
Published: March 2022

AimThis study was conducted in order to evaluate the association between metformin use and clinical outcomes in type 2 diabetes mellitus (T2DM) patients hospitalized with coronavirus disease 2019 (COVID-19).MethodsPatients with T2DM with confirmed diagnosis of COVID-19 and admitted between January 21, 2020, and January 31, 2021 in Hong Kong were identified in our cohort. Exposure was defined as metformin use within 90 days prior to admission until hospital discharge for COVID-19. Primary outcome was defined as clinical improvement of ≥1 point on the WHO Clinical Progression Scale (CPS). Other outcomes were hospital discharge, recovery, in-hospital death, acidosis, hyperinflammatory syndrome, length of hospitalization, and changes in WHO CPS score.ResultsMetformin use was associated with greater odds of clinical improvement (OR = 2.74, p = 0.009), hospital discharge (OR = 2.26, p = 0.009), and recovery (OR = 2.54, p = 0.005), in addition to lower odds of hyperinflammatory syndrome (OR = 0.71, p = 0.021) and death (OR = 0.41, p = 0.010) than control. Patients on metformin treatment had a shorter hospital stay (−2.76 days, p = 0.017) than their control counterparts. The average WHO CPS scores were significantly lower in metformin users than non-users since day 15 (p &lt; 0.001). However, metformin use was associated with higher odds of acidosis.ConclusionsMetformin use was associated with lower mortality and lower odds for hyperinflammatory syndrome. This provides additional insights into the potential mechanisms of the benefits of metformin use in T2DM patients with COVID-19.