bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testicular torsion in an undescended testicle: chasing a diagnosis
Authors: Reed Benedict , Banerjee Rishi , Tsampoukas Georgios , Gray Robert 
Published: June 2022

Abstract
Undescended testicles (UTs) and torsion of the testicle are a rare clinical combination. Symptoms may be misleading and interpreted as signs of other common conditions. Moreover, late identification of an UT may significantly delay the diagnosis and lead to adverse outcomes. Here, we present a case of a 17-year-old boy with cerebral palsy and learning disabilities who presented with painful right-sided inguinal mass. Intraoperatively, he was confirmed to have torsion of an UT and orchidectomy was performed. This article also emphasizes the importance of early diagnosis of testicular ectopia.
Small bowel obstruction caused by appendiceal and ileal endometriosis: a case report
Authors: Kobayashi Kazuki , Yamadera Masato , Takeo Hiroaki , Murayama Michinori 
Published: June 2022

Abstract
Endometriosis is characterized by the presence of an ectopic endometrial gland. Intestinal endometriosis with small bowel obstruction is uncommon. In this case, a 37-year-old woman with no history of endometriosis presented with a chief complaint of abdominal pain. Computed tomography revealed a distal small bowel obstruction. Surgical intervention was performed because of the emergent abdominal condition and the potential resistance to conservative management. Histopathological examination revealed appendiceal and ileal endometriotic lesions. Preoperative diagnosis was difficult because there were no specific clinical features. Intraoperatively, it is difficult to distinguish intestinal endometriosis and bowel malignancy; thus, oncological resection should be performed.
The radial recurrent artery propeller flap for elbow coverage in an extensive burn
Authors: Wallace David L , Rogers Alan D 
Published: June 2022

Abstract
Obtaining durable coverage of the elbow may be challenging when surrounding tissue as well as standard free flap donor sites are not available for use. Here we describe the application of the radial recurrent artery perforator propeller flap to good effect for the coverage of the elbow joint and ulnar nerve in the context of an extensive flame burn injury of over 80% of the body surface area. Despite few descriptions of its use in the literature, it is a relatively straightforward flap to elevate and inset, the donor area was effectively autografted and there were no postoperative complications.
Successful treatment of rectal cancer with pelvic abscess using transrectal drainage followed by laparoscopic radical resection: a case report
Authors: Nishina Yusuke , Ohta Hiroyuki , Terada Yoshitaka , Akabori Hiroya , Kitamura Naomi , Nagai Nozomi , Mekata Eiji 
Published: June 2022

Abstract
The incidence of rectal cancer with a pelvic abscess is rare; hence, treatment strategies are difficult because both malignant and infectious inflammation need to be addressed. Here, we report the case of a 53-year-old man diagnosed with rectal cancer accompanied by a pelvic abscess. We performed transrectal drainage of the abscess, and a transanal rectal drainage tube was inserted into the abscess cavity. His symptoms rapidly improved, and computed tomography showed that the pelvic abscess had disappeared. Six weeks after drainage, radical laparoscopic Hartmann’s procedure with resection of the rectal cancer and incision drainage scar was performed. After adjuvant chemotherapy, laparoscopic stoma closure was performed a year after the operation. The patient showed no evidence of cancer recurrence 1.5 years after radical surgery. Transrectal drainage followed by laparoscopic radical resection can be a less invasive and effective treatment for rectal cancer accompanied by a pelvic abscess.
A curious adult case of small bowel volvulus with congenital malrotation
Authors: Tan Hao Han , Sivasuthan Goutham , Wong Man-Shun 
Published: June 2022

Abstract
Intestinal volvulus is defined as a twisting of the bowel on its mesentery. It itself is a rare occurrence, with documented incidence of 1% as the cause of all small bowel obstruction, with further 0.82% of them being associated with intestinal malrotation. The classical radiographic feature described in literatures is the whirlpool sign. We herein report a rare presentation of congenital malrotation causing a small bowel obstruction in a 43-year-old man. The patient presented with acute abdominal pain and underwent an emergency laparotomy and resection of small and large bowel (total of 3 m with primary anastomosis), with an estimated 2.6 m of viable small bowel left. The patient had a prolonged recovery complicated by another relook operation, superior mesenteric vein thrombus and a high-output stoma with subsequent electrolyte derangements and acute kidney injury. He was discharged on Day 26 and had been seen in the outpatient department with good functionality.
AGN X-ray spectroscopy with neural networks
Authors: Parker M L , Lieu M , Matzeu G A 
Published: June 2022

ABSTRACT
We explore the possibility of using machine learning to estimate physical parameters directly from active galactic nucleus (AGN) X-ray spectra without needing computationally expensive spectral fitting. Specifically, we consider survey quality data, rather than long pointed observations, to ensure that this approach works in the regime where it is most likely to be applied. We simulate Athena Wide Field Imager spectra of AGN with warm absorbers, and train simple neural networks to estimate the ionization and column density of the absorbers. We find that this approach can give comparable accuracy to spectral fitting, without the risk of outliers caused by the fit sticking in a false minimum, and with an improvement of around three orders of magnitude in speed. We also demonstrate that using principal component analysis to reduce the dimensionality of the data prior to inputting it into the neural net can significantly increase the accuracy of the parameter estimation for negligible computational cost, while also allowing a simpler network architecture to be used.
Oxygen and calcium nebular emission line relationships in core-collapse supernovae and Ca-rich transients
Authors: Prentice S J , Maguire K , Siebenaler L , Jerkstrand A 
Published: June 2022

ABSTRACT
This work examines the relationships between the properties (flux ratios, full width at half-maximum velocities) of the [O i] λλ6300, 6364, [Ca ii] λλ7291, 7323, and the Ca ii near-infrared triplet, emission lines of a large sample of core-collapse supernovas (SNe) and Ca-rich transients (509 spectra of 86 transients, of which 10 transients are Ca-rich events). Line-flux ratios as a function of time were investigated with differences identified between the transient classes, in particular the Type II SNe were found to have distinct line-flux ratios compared to stripped-envelope (SE) SNe. No correlation was found between the [Ca ii]/[O i] flux ratios of SE-SNe and their ejecta masses and kinetic energies (as measured from light-curve modelling), suggesting that there may be a contribution from an additional power source in more luminous SE-SNe. We found that the mean characteristic width of the [Ca ii] emission line is less than the [O i] emission line for all SN types, indicating that the [Ca ii] emission typically originates from deeper in the ejecta than [O i]. This is in some tension with standard models for emission in Type II SNe. The emission line properties of Type II SNe were also compared to theoretical models and found to favour lower mass tracks (MZAMS&lt; 15 M⊙), with no evidence found for significant mixing of 56Ni into the H envelope nor Ca mixed into the O shell. The flux ratios of some superluminous SNe were found to be similar to those of SE-SNe when scaling to account for their longer rise times was applied (although we caution the sample size is small).
Using Music to Address Trauma with Refugees: A Systematic Review and Recommendations
Authors: Bernard Gabriella , Dvorak Abbey L 
Published: June 2022

Abstract
Refugees experience trauma and are more vulnerable than the general population to experiencing mental health conditions. Music may be used to support and enhance the lives of refugees. The purpose of this systematic review was to summarize and describe the uses of music to address trauma for individuals who are refugees. The research questions included (a) What are the characteristics of studies using music to address trauma for people who are refugees? and (b) What are the outcomes of these studies, and how are these outcomes measured? The researchers gathered available literature from PsycInfo, ERIC, Sociological Abstracts, PubMed, Music Index, and Directory of Open Access Journals (DOAJ). Databases were searched using “music” AND “refugee.” Search filters aimed to select articles that were peer-reviewed and published quantitative, qualitative, or mixed-methods studies. Of the 1,318 studies first identified, 11 met the criteria for inclusion. Studies included qualitative and quantitative approaches; the most common research design was case study. The majority of participants were adult refugees from a variety of countries, with approximately a third of the studies conducted in Australia. The majority of interventionists identified as music therapists. Treatment length varied from several days to 18 months, typically occurring once or twice weekly. Music interventions included a combination of methods, with receptive and recreative most common. Outcomes included improvements in behavioral and psychological functioning, with a variety of measurement tools used. Implications and recommendations for music therapy clinical practice are discussed.
Diversity within the neurosurgical oncology workforce in the United States: A cross-sectional study with proposed strategies to pave the path forward
Authors: Asfaw Zerubabbel Ketema , Rodriguez Analiz , Hodges Tiffany Renee , Mazumdar Madhu , Zhan Serena , Lim Michael , Germano Isabelle Margherita 
Published: June 2022

Abstract

Background
Improving and fostering diversity within the neurosurgical workforce has become a high priority. This cross-sectional study aims to provide data on the diversity of neurosurgical oncology faculty (NSOF) in the US.

Methods
All 115 neurosurgery (NS) Accreditation Council for Graduate Medical Education (ACGME) accredited programs were included in this study. The academic rank, academic and clinical title(s), gender, race, and hiring date of neurosurgical faculty with a primary focus on neurosurgical oncology (NSOF) were recorded. Geographical distribution and “top 10” programs were tabulated according to published data. Underrepresented minorities in medicine (URiM) faculty were identified according to the AAMC definition.

Results
The NSOF workforce constitutes 21% of the total NS faculty. Of these, 10.1% are women and 9.9% are URiM (P &lt; .001). Currently, 58% of neurosurgery programs (NSP) do not have URiM and/or women NSOF. The top 10 ranked NSP, according to Blue Ridge Institute for Medical Research, had a significantly less URiM NSOF (P = .019) than nontop 10 ranked programs. There was a decreasing trend in the proportion of URiM at higher academic ranks (P = .019). All of the URiM department chairs (3/113)—all men—and 1/3 women department chairs nationwide subspecialized in neurosurgical oncology.

Conclusions
Neurosurgical oncology is a sought-after subspecialty attracting a fifth of neurosurgeons practicing in ACGME-accredited training programs. Changing demographics and the benefits of workforce diversity represent a great opportunity for our field to continue leading inclusion efforts and attracting the best and brightest.
Pharmacologic Management of Mycobacterium chimaera Infections: A Primer for Clinicians
Authors: Mason Matt , Gregory Eric , Foster Keith , Klatt Megan , Zoubek Sara , Eid Albert J 
Published: June 2022

Abstract
Mycobacterium chimaera, a member of the Mycobacterium avium complex, can cause infections in individuals after open heart surgery due to contaminated heater-cooler units. The diagnosis can be challenging, as the incubation period can be quite variable, and symptoms are nonspecific. In addition to aggressive surgical management, combination pharmacologic therapy is the cornerstone of therapy, which should consist of a macrolide, a rifamycin, ethambutol, and amikacin. Multiple second-line agents may be utilized in the setting of intolerances or toxicities. In vitro susceptibility of these agents is similar to activity against other species in the Mycobacterium avium complex. Drug–drug interactions are frequently encountered, as many individuals have chronic medical comorbidities and are prescribed medications that interact with the first-line agents used to treat M. chimaera. Recognition of these drug–drug interactions and appropriate management are essential for optimizing treatment outcomes.
Timing of Patient Management Decisions Relative to Echocardiography in Staphylococcus aureus Bacteremia: A Single-Center Retrospective Analysis
Authors: Aldred Bruce , Drekonja Dimitri Maximilian 
Published: June 2022

Abstract

Background
In patients with Staphylococcus aureus bacteremia (SAB), endocarditis evaluation includes transthoracic echocardiography (TTE) and, in patients at increased risk of endocarditis, subsequent transesophageal echocardiography (TEE). Whether performing TTE before TEE influences clinicians’ decision making has not been well studied in patients deemed to warrant TEE.

Methods
In this retrospective case series, we studied clinician behavior at a large Veterans Affairs medical center regarding the care of adult patients diagnosed with SAB who completed both TTE and TEE (n = 206 episodes of SAB). The timing of key patient management decisions was compared to the timing of the patient’s TTE and TEE. It was inferred whether each management decision could have been informed by TTE alone versus TTE plus subsequent TEE. Management decisions included the following: documentation of antibiotic treatment duration, initiation of synergistic antibiotics, consultation of relevant specialists, ordering of relevant imaging studies, and performance of valve surgery or cardiac device explanation.

Results
The primary outcome (any of the above 5 management decisions taking place) occurred after completion of TTE but before TEE in 13 SAB episodes (6.3%). The primary outcome occurred after completion of both TTE and TEE in 178 SAB episodes (86.4%). Documentation of antibiotic treatment duration accounted for the large majority of observed management decisions.

Conclusions
Among patients with SAB who are deemed to warrant TEE for endocarditis evaluation, TTE results alone rarely prompt clinical management decisions.
Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort
Authors: Swain Subhashisa , Fernandes Gwen Sascha , Sarmanova Aliya , Valdes Ana M , Walsh David A , Coupland Carol , Doherty Michael , Zhang Weiya 
Published: June 2022

Abstract

Objectives
The aims were to examine the prevalence of comorbidities and role of oral analgesic use in people with knee pain (KP) compared with those without.

Methods
The Knee Pain and related health In the Community (KPIC) cohort comprises community-derived adults aged ≥40 years, irrespective of knee pain. Thirty-six comorbidities across 10 systems were compared between people with KP and controls without KP or knee OA. Multivariable logistic regression analysis was used to determine the adjusted odds ratio (aOR) and 95% CI for multimorbidity (at least two chronic conditions) and each specific comorbidity. Both prescribed and over-the-counter analgesics were included in the model, and their interactions with KP for comorbidity outcomes were examined.

Results
Two thousand eight hundred and thirty-two cases with KP and 2518 controls were selected from 9506 baseline participants. The mean age of KP cases was 62.2 years, and 57% were women. Overall, 29% of the total study population had multimorbidity (KP cases 34.4%; controls 23.8%). After adjustment for age, sex, BMI and analgesic use, KP was significantly associated with multimorbidity (aOR 1.35; 95% CI 1.17, 1.56) and with cardiovascular (aOR 1.25; 95% CI 1.08, 1.44), gastrointestinal (aOR 1.34; 95% CI 1.04, 1.92), chronic widespread pain (aOR 1.54; 95% CI 1.29, 1.86) and neurological (aOR 1.32; 95% CI 1.01, 1.76) comorbidities. For multimorbidity, the use of paracetamol and opioids interacted positively with KP, whereas the use of NSAIDs interacted negatively for seven comorbidities.

Conclusion
People with KP are more likely to have other chronic conditions. The long-term benefits and harms of this change remain to be investigated.

Trial registration
ClinicalTrials.gov, http://clinicaltrials.gov, NCT02098070.
Oral supplementation of alkaline phosphatase in poultry and swine
Authors: Escobar Jeffery , Dobbs Merilyn , Ellenberger Claudia , Parker Alysia , Latorre Juan D , Gabor Leslie 
Published: June 2022

Abstract
The importance of intestinal alkaline phosphatase (IAP) in maintaining gut health and intestinal homeostasis is well established. The objective of this study was to investigate the tolerance of poultry and swine to dietary supplementation of a novel microbial-derived alkaline phosphatase (AP; E.C. 3.1.3.1 produced by Paenibacillus lentus strain CMG3709). Studies were conducted on day-old Ross 308 chicken (n = 1,000; Study 1) and weaned piglets (n = 180; Study 2) for a duration of 42 d; and consisted of four treatment groups (TG) based on the concentration of microbial-derived AP supplemented in their diet at 0; 12,000; 20,000; and 200,000 U/kg of feed. Parameters such as animal survival, hematology, coagulation, and biochemical indices were assessed at the end of the study. The effect of microbial AP on nutrient absorption through skin pigmentation and intestinal permeability were also investigated in broilers (n = 600; Study 3). In poultry (Study 1), there were no statistically significant differences between control and TG for any of the hematological and biochemical parameters, except for a marginal increase (P &lt; 0.05) in serum phosphorus at the highest dose. This variation was not dose-dependent, was well within the reference range, and was not associated with any clinical correlates. In swine (Study 2), hematological parameters such as leukocyte, basophil, and lymphocyte counts were lower (P &lt; 0.05) for the two highest doses but were traced back to individual variations within the group. The biochemical indices in piglets showed no significant differences between control and supplemental groups except for glucose (P = 0.0005), which showed a high effect (P = 0.008) of the random blood collection order. Nonetheless, glucose was within the normal reference range, and were not related to in-feed supplementation of AP as they had no biological significance. The survival rate in all three studies was over 98%. Dietary supplementation of microbial-derived AP up to 16.7 times the intended use (12,000 U/kg feed) level had no negative effects in both poultry and swine. In-feed supplementation of microbial-derived AP for 28 d improved intestinal pigment absorption (P &lt; 0.0001) and reduced intestinal paracellular permeability (P = 0.0001) in broilers (Study 3). Based on these results, it can be concluded that oral supplementation of microbial-derived AP is safe for poultry and swine and effective at improving gut health in poultry.
Berberine Bridge Enzyme-like Oligosaccharide Oxidases Act as Enzymatic Transducers Between Microbial Glycoside Hydrolases and Plant Peroxidases
Authors: Scortica Anna , Giovannoni Moira , Scafati Valentina , Angelucci Francesco , Cervone Felice , De Lorenzo Giulia , Benedetti Manuel , Mattei Benedetta 
Published: June 2022

Oligogalacturonide (OG)-oxidase 1 (OGOX1) and cellodextrin (CD)-oxidase (CELLOX) are plant berberine bridge enzyme-like oligosaccharide oxidases that oxidize OGs and CDs, cell-wall fragments with the nature of damage-associated molecular patterns. The oxidation of OGs and CDs attenuates their elicitor activity and concomitantly releases H2O2. By using a multiple enzyme–based assay, we demonstrate that the H2O2 generated downstream of the combined action between a fungal polygalacturonase and OGOX1 or an endoglucanase and CELLOX can be directed by plant peroxidases (PODs) either towards a reaction possibly involved in plant defense, such as the oxidation of monolignol or a reaction possibly involved in a developmental event, such as the oxidation of auxin (indole-3-acetic acid), pointing to OGOX1 and CELLOX as enzymatic transducers between microbial glycoside hydrolases and plant PODs. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Dissecting the relationship between plasma and tissue metabolome in a cohort of women with obesity: Analysis of subcutaneous and visceral adipose, muscle, and liver
Authors: Wu Zhanxuan E. , Kruger Marlena C. , Cooper Garth J. S. , Sequeira Ivana R. , McGill Anne‐Thea , Poppitt Sally D. , Fraser Karl 
Published: June 2022

AbstractUntargeted metabolomics of blood samples has become widely applied to study metabolic alterations underpinning disease and to identify biomarkers. However, understanding the relevance of a blood metabolite marker can be challenging if it is unknown whether it reflects the concentration in relevant tissues. To explore this field, metabolomic and lipidomic profiles of plasma, four sites of adipose tissues (ATs) from peripheral or central depot, two sites of muscle tissue, and liver tissue from a group of nondiabetic women with obesity who were scheduled to undergo bariatric surgery (n = 21) or other upper GI surgery (n = 5), were measured by liquid chromatography coupled with mass spectrometry. Relationships between plasma and tissue profiles were examined using Pearson correlation analysis subject to Benjamini–Hochberg correction. Plasma metabolites and lipids showed the highest number of significantly positive correlations with their corresponding concentrations in liver tissue, including lipid species of ceramide, mono‐ and di‐hexosylceramide, sphingomyelin, phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysophosphatidylethanolamine, dimethyl phosphatidylethanolamine, ether‐linked PC, ether‐linked PE, free fatty acid, cholesteryl ester, diacylglycerol and triacylglycerol, and polar metabolites linked to several metabolic functions and gut microbial metabolism. Plasma also showed significantly positive correlations with muscle for several phospholipid species and polar metabolites linked to metabolic functions and gut microbial metabolism, and with AT for several triacylglycerol species. In conclusion, plasma metabolomic and lipidomic profiles were reflective more of the liver profile than any of the muscle or AT sites examined in the present study. Our findings highlighted the importance of taking into consideration the metabolomic relationship of various tissues with plasma when postulating plasma metabolites marker to underlying mechanisms occurring in a specific tissue.