bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration
Authors: Xiong Wenjun , Chen Yuehong , Zhang Chaoting , Li Jin , Huang Haipeng , Zhu Yu , Deng Guangxu , Cheng Junhong , Lin Yixiong , Shi Zhimin , Mou Tingyu 
Published: November 2022

Abstract
Background
Recent studies have discovered an emerging role IL11 in various colitis-associated cancers, suggesting that IL11 mainly promotes tumor cell survival and proliferation in regulating tumorigenesis. Herein we aim to reveal a novel function of IL-11 through STAT3 signaling in regulating tumor immune evasion.
Results
IL11 is highly expressed in CRC and indicates unfavorable prognosis. IL11 knockout increased CD8 + T cell infiltration and reduced intestinal and colon formation. Tumors were significantly suppressed while MHC-I and CXCL9 expression for CD8+ T infiltration were remarkably increased in the tumor tissues of Apcmin/+/Il11−/− mice or Il11−/− mice induced by AOM/DSS. IL11/STAT3 signaling downregulated MHC-I and CXCL9 by inhibiting IFNγ-induced STAT1 phosphorylation. IL11 mutein competitively inhibit IL11 to upregulate CXCL9 and MHC-I in tumor and attenuated tumor growth.
Conclusions
This study ascribes for a new immunomodulatory role for IL11 during tumor development that is amenable to anti-cytokine based therapy of colon cancer.
Analysis of the direct antiglobulin test for rates of phototherapy among ABO-incompatible newborns
Authors: Gabbay Jonathan , Agneta Elizabeth , Turkington Simon , Bajaj Benjamin , Sinha Bharati , Geha Tanya 
Published: November 2022

Abstract
Objective:
We analyze phototherapy rates after implementation of a Hyperbilirubinemia Clinical Pathway (HCP), which placed ABOi newborns with negative DAT on the low risk phototherapy nomogram, rather than medium risk, as previously done.
Study Design:
A chart review was performed for ABOi newborns born > 36 weeks gestation between January 2020 and October 2021. Primary outcome measures were rates of phototherapy across pre- and post-intervention groups and between DAT negative and DAT positive newborns.
Results:
There were no phototherapy rate differences among the intervention groups, including among DAT negative newborns. DAT positive newborns had increased rates of phototherapy only in the post-intervention group, which was no longer significant when stratified by risk curve.
Conclusions:
Providers adhered to the guidelines, although there were no changes in rates of phototherapy. We show that among ABOi newborns, differing risk curve assignments based on DAT status does not appear to impact rates of phototherapy.
Use of 3-Dimensional Printing at the Point-of-Care to Manage a Complex Wound in Hemifacial Necrotizing Fasciitis: A Case Report
Authors: Nyirjesy Sarah Christine , Judd Ryan T , Alfayez Yazen , Lancione Peter , Swendseid Brian , von Windheim Natalia , Nogan Stephen , Seim Nolan B , VanKoevering Kyle K 
Published: November 2022

Abstract
Background:
Complex facial wounds can be difficult to stabilize due to proximity of vital structures. We present a case in which a patient-specific wound splint was manufactured using computer assisted design and three-dimensional printing at the point-of-care to allow for wound stabilization in the setting of hemifacial necrotizing fasciitis. We also describe the process and implementation of the United States Food and Drug Administration Expanded Access for Medical Devices Emergency Use mechanism.
Case Presentation:
A 58-year-old female presented with necrotizing fasciitis of the neck and hemiface. After multiple debridements, she remained critically ill with poor vascularity of tissue in the wound bed and no evidence of healthy granulation tissue and concern for additional breakdown towards the right orbit, mediastinum, and pretracheal soft tissues, precluding tracheostomy placement despite prolonged intubation. A negative pressure wound vacuum was considered for improved healing, but proximity to the eye raised concern for vision loss due to traction injury. As a solution, under the Food and Drug Administration’s Expanded Access for Medical Devices Emergency Use mechanism, we designed a three-dimensional printed, patient-specific silicone wound splint from a CT scan, allowing the wound vacuum to be secured to the splint rather than the eyelid.
After five days of splint-assisted vacuum therapy, the wound bed stabilized with no residual purulence and developed healthy granulation tissue, without injury to the eye or lower lid. With continued vacuum therapy, the wound contracted to allow for safe tracheostomy placement, ventilator liberation, oral intake, and hemifacial reconstruction with a myofascial pectoralis muscle flap and a paramedian forehead flap one month later. She was eventually decannulated and at six-month follow-up has excellent wound healing and periorbital function.
Conclusions:
Patient-specific, three-dimensional printing is an innovative solution that can facilitate safe placement of negative pressure wound therapy adjacent to delicate structures. This report also demonstrates feasibility of point-of-care manufacturing of customized devices for optimizing complex wound management in the head and neck, and describes successful use of the United States Food and Drug Administration’s Expanded Access for Medical Devices Emergency Use mechanism.
New Records of Hermit Crabs (Crustacea: Decapoda: Anomura: Paguroidae) from the Andaman and Nicobar Archipelago in India
Authors: Paul Pranoy , Thiruchitrambalam Ganesh 
Published: November 2022

Abstract

The current work presents hermit crab species inhabiting the intertidal and shallow subtidal region on the coast of south Andaman Islands, along with an updated checklist of hermit crabs from Andaman and Nicobar Islands (ANI) and an identification key for surveyed hermit crabs. Five species of hermit crabs representing two families (Coenobitidae and Diogenidae) under the superfamily Paguroidea were recorded in the intertidal and shallow subtidal regions of the south Andaman Islands. Among the five species, one species of the genusCoenobita, one species of the genusCalcinus, two species of the genusClibanariusand one species of the genusDardanusare reported for the first time from the intertidal habitats of the Andaman Islands. Live coloration and description of several species are described for the first time from this region.
Differential expression patterns of long noncoding RNAs in a pleiomorphic diatom and relation to hyposalinity
Authors: Debit Ahmed , Charton Florent , Pierre-Elies Priscillia , Bowler Chris , de Carvalho Helena Cruz 
Published: November 2022

Abstract
The pennate marine diatom Phaeodactylum tricornutum is the only known diatom that has a demonstrated morphological plasticity, occurring in three distinct morphotypes: fusiform, triradiate and oval. Although the morphotypes are interchangeable, the fusiform is the dominant one while both the triradiate and the oval forms are less common, the latter often being associated with stress conditions such as low salinity and solid culture media, amongst others. Previous work has shown the occurrence of long noncoding (lnc)RNAs in P. tricornutum, many of which are expressed under specific stress conditions. Using twelve previously published transcriptomic datasets originating from the three morphotypes of P. tricornutum, we sought to investigate the expression patterns of lncRNAs (lincRNAs and NATs) using pairwise comparisons. We found that, as with protein coding genes, the fusiform and triradiate morphotypes show the least number of differentially expressed lncRNAs between them. Furthermore, differentially expressed lncRNAs cluster according to morphotype, indicating that lncRNAs are not randomly expressed, but rather that they seem to provide a specific (noncoding) transcriptomic signature of the morphotype. Finally, we present evidence to suggest that the major differences in DE genes (both noncoding and coding) between the oval morphotype and the most common fusiform morphotype could be mostly due to the hyposaline culture conditions rather than to the morphotype difference itself.
Ultra-Compact and Low Delay Time All Optical Half Adder Based on Photonic Crystals
Authors: Parandin Fariborz 
Published: November 2022

Abstract
Photonic crystals are flexible structures that can be used to design a variety of optical devices. One of the important purposes of using photonic crystals is to use them in optical integrated circuits. To design and implement these devices as integrated circuits, they must have both small dimensions and a simple structure. In this paper, an optical half adder is designed using photonic crystals. One of the features of this half adder is its small size. Also, a square lattice has been used in designing this structure, which is simpler than other structures. In designing this structure, it has been tried that the power values in high and low logic modes have a large difference to reduce their detection error at the output. For the sum and carry outputs, the obtained contrast ratio in the designed half adder is 15.4dB and 7.4dB, respectively. The small size of this structure and the use of simple point defects, and their small number have caused the maximum delay time of this structure to be reduced to 0.07ps.
Construction of a base ontology to represent accident expertise knowledge
Authors: SOUNCHIO Serge SONFACK , FOGUEM Bernard KAMSU , GENESTE Laurent 
Published: November 2022

Abstract
Expertise is an activity carried out by experts that contributes to societal progress, as it helps to elucidate unknown situations. Forexample, accident expertise eases accident understanding, by describing how it happened, and by identifying its causes and conse-quences. As a result, the design of accident expertise in a convenient human-machine structure will enable the querying, reasoning,and reuse of accident knowledge in other tools, such as safety and decision-making systems. However, existing representations ofaccident knowledge, such as documents, relational databases, or accident ontologies, do not fulfill accident expertise expectations.Moreover, these representations are unlikely to provide the appropriate use of accident expertise knowledge.
This study presents a base ontology for accident expertise knowledge representation designed with a model-driven methodologyand implemented with semantic web technologies. The study obtained satisfactory results from the evaluation and application ofextension and reuse of this ontology with aircraft accident expertise taken from the French bureau of Enquiries and Analysis (BEA)for civil aviation safety.
Defining and enacting “responsible sexual behavior” in rural Iowa
Authors: Loew Nicole , Mackin Melissa Lehan 
Published: November 2022

Abstract

Objective: Individual level or personal “responsibility” is often implicitly or explicitly used to improve sexual health outcomes. Rural women face unique contextual barriers that increase their risk for poorer sexual health. Therefore, the objective of this study was to understand how rural Iowa women define responsible sexual behavior (RSB) and to identify what contextual variables influence these women’s ability to enact their definitions.
Study Design, Setting, and Participants: This qualitative descriptive study used a semi-structured interview guide to conduct telephone interviews with rural women living in non-core Iowa counties who have had (or planned to have) sex with men. Data were analyzed using within and across case analysis to produce defining and enacting themes of responsible sexual behavior.
Results: Ten women from eight Iowa counties completed telephone interviews. For rural women in this sample, RSB was defined as understanding the consequences of sex and taking action to manage risks by using contraception or abstinence, “knowing” your partner, and seeking knowledge and resources. The rural context influenced how participants acquired information and created barriers to enacting responsible sexual behavior.
Conclusion: Rural women’s definition of responsible sexual behavior did not align with rural values about sexuality. As a result, women often relied on informal information and resources. Emphasizing community-level interventions that act on contextual influences over individual approaches may further assist rural women in enacting responsible sexual behavior.
Flavonoids Attentuate Cancer Metabolism by Modulating Redox State, lipid metabolism, and use of amino acids or ketone bodies
Authors: Samec Marek , Mazurakova Alena , Lucansky Vincent , Koklesova Lenka , Pecova Renata , Pec Martin , Golubnitschaja Olga , Al-Ishaq Raghad Khalid , Caprnda Martin , Gaspar Ludovit , Prosecky Robert , Gazdikova Katarina , Adamek Mariusz , Büsselberg Dietrich , Kruzliak Peter , Kubatka Peter 
Published: November 2022

AbstractMetabolic reprogramming of cancer cells is a common hallmark of malignant transformation. Cancer cells rewire metabolism to meet increased nutritional requirements necessary for enhanced cellular proliferation and growth. The preference for aerobic glycolysis over oxidative phosphorylation in tumors is a well-studied phenomenon known as the Warburg effect. Importantly, metabolic transformation also involves an alteration in signaling cascades contributing to lipid metabolism, amino acid flux and synthesis, redox balance, and utilization of ketone bodies as an alternative fuel promoting carcinogenesis. Flavonoids, widely distributed phytochemicals in plants, exert various beneficial effects on human health through modulating molecular cascades altered in the pathological phenotype. Recent evidence has identified numerous flavonoids and their derivates as modulators of critical components of cancer metabolism. Flavonoids affect lipid metabolism by regulating fatty acid synthase (FAS) or transcription activity of sterol regulatory element-binding protein 1/2 (SREBP1/2), redox balance by modulating nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activity, amino acid flux and synthesis by phosphoglycerate mutase 1 (PGAM1), or ketone bodies generation mediated by 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) in stromal cells to supplement energetic demands of epithelial cancer cells. Here, we discuss recent preclinical evidence evaluating the impact of flavonoids on cancer metabolism, focusing on lipid and amino acid metabolic cascades, redox balance, and ketone bodies. Flavonoids, which affect metabolic pathways of cancer cells by targeting critical enzymes and transporters, represent a promising avenue to accelerate cancer-related research; however, more in-depth investigation is essential to implement innovative and progressive therapeutic approaches in cancer management.
Development and validation of ferroptosis-related lncRNA features to improve prognosis prediction in ovarian cancer
Authors: Chen Keyu , Ren Xiaojing , Li Xiaohong , Qi Caixia 
Published: November 2022

Abstract
Background: Long non-coding RNAs (lncRNAs) are thought to be associated with several processes during cancer development and have been shown to be involved in the regulation of ferroptosis. Ovarian cancer is highly malignant tumour with a poor prognosis. The identification biomarkers with prognostic value in ovarian cancer may improve patient outcomes and can help to elucidate potential future therapeutic targets.
Methods: We report differential expression of 187 ferroptosis-related lncRNAs in normal and ovarian cancer tissue. Using univariate and multivariable Cox regression analysis, we identified four lncRNAs that were strongly associated with prognosis. We constructed a prognostic risk score based on these four lncRNAs which was effectively able to distinguish between low- and high-risk OC patients based on survival time. Univariate and multivariable Cox regression analyses and time-related receiver operating characteristic curve analyses revealed that this risk score represented an independent prognostic factor in patients with ovarian cancer. And qRT-PCR was performed to further validate the reliability of the prognostic model. For clinical implementation, we developed a nomogram based on the prognostic feature and patient age. Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that the four ferroptosis-related lncRNAs were related to tumour immunity. Further immune infiltration analysis was performed to identify multiple immune cells associated with ferroptosis.
Conclusions: we identify four novel ferroptosis-related lncRNAs as predictors of ovarian cancer prognosis and they could be applicable in clinical ferroptosis-related targeted therapies for ovarian cancer.
Effect of long non-coding RNA and DNA methylation on gene expression in dental fluorosis
Authors: Hu Xiaoyan , Li Huiru , Yang Minzhi , Chen Yujiong , Zeng Ailin , Wu Jiayuan , Zhang Jian , Tian Yuan , Tang Jing , Qian Shengyan , 吴 明松 
Published: November 2022

Abstract
In the process of tooth development, the interaction between genetic information, epigenetic inheritance and environment jointly affects the formation of teeth. At present, the mechanism of dental fluorosis is rarely studied from transcriptomics, and there is no report on epigenetic perspective. In the study, SD rats were divided into dental fluorosis group and control group fed with NaF (150 mg/L) or distilled water for 8 weeks. After 3.5 days of birth, the RNAs or DNA of rat mandibular molars were detected by RNA-seq or MethylTarget respectively. The rerults demonstrated that a total of 1723 differentially expressed genes (DEGs) and 2511 differential expression lncRNAs (DE-lncRNAs) were mainly involved in the changes of ion channels, calcium ion transport and immunomodulatory signaling pathways. ATP2C1 and Nr1d1, which were related to Ca2+ transport, cellular calcium homeostasis, endoplasmic reticulum stress and immunity, may be the key genes in the formation of dental fluorosis. Notably, we also found that the immune response plays an important role in the formation of dental fluorosis, and a large amount of DEGs was enriched in immune regulation and NF-κB signaling pathways. Furthermore, the methylation levels of 13 sites were increased in Ago4, Atf3, Atp2c1, Dusp1, Habp4, Mycl while methylation levels of 5 CpG sites decreased in Ago4, Atp2c1, Habp4, Traf6 and conformably the expression of these genes have been significantly changed. This study comprehensively analyzed the occurrence mechanism of dental fluorosis from transcriptomics and epigenetics, so as to provide theoretical reference for further research.
Dissolved-Cl2 Triggered Redox Reaction Enables High-performance Perovskite Solar Cells
Authors: Luo Yujie , Liu Kaikai , Yang Liu , Feng Wenjing , Zheng Lingfang , Shen Lina , Jin Yongbin , Fang Zheng , Song Peiquan , Tian Wanjia , Xu Peng , Li Yuqing , Tian Chengbo , Xie Li-Qiang , Wei Zhanhua 
Published: November 2022

Abstract
Constructing 2D/3D perovskite heterojunction has been proven to be an effective strategy for fabricating high-performance perovskite solar cells (PSCs). However, previous reports only physically deposit a 2D perovskite passivation layer on the 3D perovskite layer. These methods are limited to surface passivation only, and the bulk 3D perovskite remains defective. Herein, we propose Cl2-dissolved chloroform as a multifunctional and reactive solvent for constructing the 2D/3D perovskite heterojunction. Specifically, the dissolved Cl2 reacts with the 3D perovskite, leading to Cl/I ionic exchange. The generated Cl- anions further diffuse to passivate the buried interface of PSCs, improving the bulk and interface quality. Additionally, hexylammonium bromide reacts with the residual PbI2 to form 2D/3D heterojunctions on the surface. As a result, we achieved high-performance PSCs with a champion efficiency of over 24% and substantially improved operational stability, retaining 80% of the initial efficiency after working for 905 h at the maximum power point.
States and Micronations in Cyberspace under Public International Law:
A Legal Analysis of the Case of the Republic of Errant Menda Lerenda
Authors: Zhuk Alesia 
Published: November 2022

Abstract
The purpose of this article is to analyse whether the Republic of Errant Menda Lerenda (¨REML¨) can be considered a micronation or a State under public international law, based on existing doctrine and the actual situation of other states similar to the REML, whose performance in the legal framework of public international law has led to a rethinking of basic postulates. Both cases analyse whether a nation and a State can exist solely in cyberspace. For the purposes of this article, the analysis is based on the following assumptions: 1.- More than one REML can exist, and for the purposes of this conclusion, possible problems arising from the use of the same flag or name are not considered. 2.- It is assumed that the REML that is the subject of this study was created first and is the subject of the document in Appendix 1–3, which is assumed to be correct in date, content and other considerations. 3.- As a working assumption, it is assumed that the REML has a territory (consisting of a sovereign and its space) and that the entire population of the REML is a sovereign.
"Sex Without Sexual Attraction?": Perceived Sexual Experiences of Indian Sex-positive Asexuals
Authors: Agrawal Nandini , Shainy Munna R. , Sebastian Jane , Srivast Akriti 
Published: November 2022

Abstract
Amidst the vast majority of literature that either quantify the extent to which one identifies to be asexual or creates an atomistic perspective of the asexual spectrum which reiterates the false notion that all asexuals are aversive to sex, the current qualitative inquiry aimed to describe the sexual experiences of sex-positive asexuals who are rarely mentioned in academia. Fifteen Indian sex-positive asexuals who have engaged in either self-pleasure or partnered sex, and even both, were recruited for the study. The individual semi-structured interviews that captured their perceptions of their own sexual experiences were thematically analysed to cover the same important phenomena. The experiences associated with developing own identity in terms of sexual activity included self-exploration helping in self-acceptance, feeling of being different and a preference of the type of sexual activities. The participants also reported how their preconceptions about sex based on media and peer engagement differed from what it really was. Emotional experiences during self-pleasure and partnered sex were found to be radically different for most of the participants. Recognising why self-pleasure is important to them and the impacts they believe it had, were commonly observed. It was also found that the participants had a clear understanding of their own roles and the extent of efforts to be put into self-pleasure activities and partnered sex. During the normal human experience of physiological arousal, which is purely based on non-sexual factors about the partner or a potential one, they resort to indulging in sex with them or pleasuring themselves. A dichotomy in terms of the intrinsic and extrinsic reasons for why they indulged in self-pleasure or partnered sex was observed. The results of the study are pivotal in developing inclusive practises, sex education and community awareness about this particular community and, most importantly, enabling representation of their experiences within the academia about sex and sexuality.