bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glycogen storage disease: PRKAG2 syndrome
Authors: Gandaeva L.  A.  , Kondakova O. B. , Basargina E. N. , Pushkov A. A. , Koloskova N. N. , Zharova O. P. , Barsky V. I. , Fisenko A. P. , Savostyanov K. V. 
Published: June 2022

PRKAG2 syndrome is a rare genetic disease that isinherited in an autosomal dominant fashion and is caused by mutationsin the PRKAG2 gene. Clinical symptoms include early onset, ventricular preexcitation, cardiac hypertrophy, and progressive atrioventricular block. The PRKAG2 syndrome is characterized by genetic heterogeneity, which makes early detection difficult; genophenotypic correlations have been documented. In this article, we provide an overview of the literature data and experience from the cardiology department of the National Medical Research Center for Children’s Health of the Russian Ministry of Health in the diagnosis and management of patients with PRKAG2 syndrome, and present the clinical and genetic characteristics of the p.R302Q and p.H383R variants of the PRKAG2 gene.
Causes and prevention options for sarcopenia in children
Authors: Zavyalova A. N. , Khavkin A. I. , Novikova V. P. 
Published: June 2022

Sarcopenia is a condition of progressive loss of muscle mass, moststudied in patients of senile age. Sarcopenia is described in children with oncological diseases, severe surgical pathology, in the perioperative period with liver transplantation, immobility in children with cerebral palsy. Sarcopenia is associated with adverse disease outcomes. This article discusses the problem of sarcopenia using the example of patients with stable dysmotility and posture. In addition to limited mobility, among the causes of sarcopenia are impairment of the ability to eat, the availability of basic nutrients and vitamin D, and a change in the intestinal microbiome. Nutritional support combined with physical rehabilitation has been shown to be effective in reversing sarcopenia.
Comparative characteristics of patients with different types of Alport syndrome inheritance
Authors: Shebalkina K. V. , Petrosyan E. K. , Shumilov P. V. 
Published: June 2022

Purpose. A comparative characterization of clinical forms and outcomes in patients with Alport syndrome with different types of inheritance.Characteristics of patients and research methods. We have conducted a retrospective controlled comparative non-randomized single-center longitudinal study that included 60 patients who were admitted to nephrology department of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University from 2004 to 2020: there were 22 (37%) girls and 38 (63%) boys from 2 to 18 years of age. The median age (Me) was 8,7 [5,4; 13,7] years old. The patients were divided into 2 groups: Group 1 received with cyclosporine A and nephroprotectors, Group 2 received nephroprotectors only.Results. We identified 75% X-linked, 20% autosomalrecessive, and 5% autosomal dominant types of inheritance among our patients. 45% manifested with combined hematuria with proteinuria, 43% of patients — with isolated hematuria, and 12% — with isolated proteinuria. Hearing damage was detected in 45% of patients, eye damage — in 5%. Nephrotic syndrome developed in 22% of patients, arterial hypertension — in 15%. In patients with X-linked Alportsyndrome, there was a statistically significant(p=0,002) reduction of proteinuria during the first 6 months of treatment in Group 1 compared to Group 2. The difference in proteinuria decrease during therapy is not statistically significant among differenttypes of inheritance. According to survival data, patients with autosomalrecessive inheritance of disease proceed more severely in comparison with other types of inheritance, and this difference tendsto be statically significant(p=0,065).Conclusion. Timely diagnosis and proper management of patients with Alport syndrome can improve the disease outcome. To determine the prognosis, it is important not only to collect detailed patient’s history and conduct morphological examination, but also to provide genetic testing to determine the type of inheritance.
Features of the content of magnesium, selenium, and strontium in the blood components of newborns and mothers at a risk of miscarriage
Authors: Sofronov V. V. , Voloshin A. V. , Skvortsova G. Sh. , Gareev B. I. , Batalin G. A. 
Published: June 2022

Purpose.This study analyzes changes in the concentration of elements — magnesium, selenium, strontium — in plasma and RBCs of peripheral blood in parturient women with a history of threatened miscarriage and their newborns. In addition, the difference in cell-membrane permeability indices for each element was determined.Characteristics of children and research methods. 97 pairs of full-term newborns and their mothers were under observation. The main cohort (Group 1) consisted of 57 mother–child pairs under a threat of miscarriage. The control group (Group 2) consisted of 40 conditionally healthy pairs. Concentrations of chemical elements were determined in plasma and RBCs using mass spectrometry with inductively coupled plasma. Statistical processing consisted of two stages. Initially, the authors determined parameters with a significant change in the concentration of elements, in the presence of a threat of abortion. Then the values of the relationships between all parameters for each element were calculated.Results.There is an increase in the concentrations of magnesium and selenium in the body of parturient women with a history of threatened miscarriage in comparison with healthy women in labor. The concentration of strontium does not change. In newborns, the concentration of magnesium also increases, and strontium decreases. The concentration of selenium in newborns does not change.Conclusion. The study findings indicate that the threat of termination of the current pregnancy is accompanied by a change in the elemental status of mothers and their newborns.
The health status of children born to mothers with preeclampsia
Authors: Karavaeva A. L. , Timofeeva L. A. , Zubkov V. V. , Kan N. E. , Tyutyunnik V. L. 
Published: June 2022

Purpose. Study of perinatal and neonatal outcomes in newborns born to mothers with preeclampsia.Characteristics of children and research methods. Perinatal outcomes were analyzed in 559 mother–newborn pairs divided into 2 groups: Group 1 included 200 children to mothers with preeclampsia (143 with moderate and 57 with severe preeclampsia). Group 2 was composed of 359 newborns to mothers with a physiological course of pregnancy. The medical history, features of the course of pregnancy, delivery, and the early neonatal period were analyzed. The condition of newborns was assessed on the Apgar scale at 1 and 5 minutes, the assessment of physical development — using centile tables for full-term and premature newborns (INTERGROWTH-21st), the assessment of neuromuscular and physical maturity on the Ballard scale.Results. The study showed that children born to mothers with preeclampsia are significantly more likely to have metabolic and hematological disorders, a higher risk of developing infectious and inflammatory diseases, and a direct correlation with the period of manifestation and severity of preeclampsia. The higher occurrence of these conditions and the structure of pathological changes in the neonatal period led to a longer stay of children of this group after birth at newborn intensive care units, and also required observation at the second stage of nursing.Conclusion. Preeclampsia is a risk factor for neonatal complications. The identified features of adaptation in newborns from patients with preeclampsia and the structure of pathological conditions in the early neonatal period should determine the management tactics and timeliness of treatment and diagnostic measures aimed at improving the provision of medical care to the pregnant woman and subsequently the newborn.
Analysis of risk factors that determine the severity of transient tachypnea of the newborn and allow predicting treatment tactics
Authors: Kovtun O. P. , Shestak E. V. , Ksenofontova O. L. 
Published: June 2022

Transient tachypnea of the newborn is a parenchymal lung disease characterized by respiratory distress in the first hours after birth. The consequences of underestimating the severity of the disease, incorrectly chosen respiratory support technique or its untimely use at the stage of the delivery room are the increase in respiratory failure, transfer to the intensive care unit, and the need for more invasive and expensive methods of treatment. In the study, we set the task to determine the risk factors that allow us to predict the severity of the course of transient tachypnea of the newborn at the stage of the delivery room.Purpose. Analysis of risk factors that determine the severity of transient tachypnea in the newborn and predicting the tactics of their treatment.Methods. Retrospective analysis of full-term newborns (n = 201) diagnosed with transient tachypnea of the newborn in 2020, who received any type of respiratory support in the first hours of life.Results. Most patients with transient tachypnea of the newborn required respiratory support at the stage of the delivery room, which we associate with a combination of risk factors in the history of pregnancy and childbirth. A high incidence of cerebral pathology in the studied newborns was revealed. According to our data, the following factors can be considered as predictors of the severity of the condition and hospitalization in the intensive care unit from the delivery room of patients with transient tachypnea of the newborn: delivery by Casarean section, low Apgar score at 1 and 5 minutes, Downs scale score of 4–5 points, and the need for respiratory support during the delivery room stage.Conclusions. The results of the study proved a high frequency of transient tachypnea of the newborn registered in full-term infants, allowed to identify risk factors for a severe course of transient tachypnea of the newborn and hospitalization in the intensive care unit.
A change in the type of neurogenic dysfunction as a result of treatment of children with neurogenic bladder subject to surgery for a spinal hernia during the newborn period
Authors: Nikitin S. S. , Guseva N. B. , Ignatiev R. O. , Morozov S. L. , Dlin V. V. 
Published: June 2022

The most severe consequence of a spinal hernia, affecting the entire life of a person, is a spinal neurogenic bladder. Its symptoms limit the child’s socialization, and the problem of urination needs constant use of various aids. At the same time, despite many studies in neurology, there are no significant shifts in the possibility of restoring the function of urination in spinal patients.Purpose. The aim of study is to analyze the long-term results of correction of neurogenic bladder in children treated depending on the type of dysfunction with a history of surgery for spinal hernia.Characteristics of children and research methods. 100 patients with spinal neurogenic bladder aged 1–15 years were examined, urodynamic studies were used. Depending on the state of the detrusor and sphincter, groups of patients were identified, in each of which treatment lasting at least a year was selected.Results. With a differentiated approach to the choice of therapeutic tactics, depending on the type of neurogenic bladder, the presence of vesicoureteral reflux, urinary tract infection, it was possible to reduce the level of detrusor hypertension, if any, or activate the function of the atonic bladder. Individual options for urinary diversion were developed. With long-term therapy that stabilizes detrusor, a change in the type of neurogenic dysfunction occurred within a year in 98 patients, which required repeated urodynamic examination to change treatment tactics.Conclusion. Clinical manifestations of spinal neurogenic bladder do not always accurately indicate the type of dysfunction. During the growth of the child, as well as under the influence of treatment, there is a change in the type of neurogenic bladder. Urodynamic examination makes it possible to determine the state of the detrusor and sphincter — and to select a pathogenetically justified treatment option. In case of impaired urination, neurogenic bladder should be corrected with customized self-catheterization. Urodynamics should be controlled in spinal patients at least once a year to correct treatment.
Analysis of hand and face images for the purpose of engineering support for Parkinson's disease diagnosis
Authors: Białek Kamila , Potulska-Chromik Anna , Jakubowski Jacek , Nojszewska Monika , Kostera-Pruszczyk Anna 
Published: June 2022

Engineering support in the field of recognizing Parkinson's disease against the background of other diseases, its progression and monitoring the effectiveness of drugs is currently widely implemented as part of work devoted to the use of re-cording and analysis devices equipped with sensors of movement parameters attached to the patient's body, e.g. accelerometers and gyroscopes. This material touches on an alternative approach, in which the concept of using techniques for processing selected image data obtained during a clinical examination evaluating a patient using the unified UPDRS number scale is proposed. The research was conducted on a material that corresponded to selected components of the scale and included images of faces recorded in the visible light range and images of the outer surfaces of the hand recorded with a thermal imaging camera. This was aimed at assessing the possibility of differentiating persons in terms of detecting Parkinson's disease on the basis of registered modalities. Thus, tasks aimed at developing characteristics important in the binary classification process were carried out. The assessment of features was made in a modality-dependent manner based on available tools in the field of statistics and machine learning.
A Protection Layer over MapReduce Framework for Big Data Privacy
Authors: Baig Hidayath Ali 
Published: June 2022

In many organizations, big data analytics has become a trend in gathering valuable data insights. The framework MapReduce, which is generally used for this purpose, has been accepted by most organizations for its exceptional characteristics. However, because of the availability of significant processing resources, dispersed privacy-sensitive details can be collected quickly, increasing the widespread privacy concerns. This article reviews some of the existing research articles on the MapReduce framework's privacy issues and proposes an additional layer of privacy protection over the adopted framework. The data is split into bits and processed in the clouds, and two other steps are taken. Hadoop splits the file into bits of a smaller scale. The task tracker then allocates these bits to several mappers. First, the data is split up into key-value pairs, and the intermediate data sets are generated. The efficiency of the suggested approach may then be effectively interpreted. Overall, the proposed method provides improved scalability. The following figures compare execution time with relation to file size and the number of partitions. As privacy protection technique is used, the loss of data content can be appropriately handled. It has been demonstrated that MRPL outperforms current methods in terms of CPU optimization, memory usage, and reduced information loss. Research reveals that the suggested strategy creates significant advantages for Big Data by enhancing privacy and protection. MRPL can considerably solve the privacy issues in Big Data.
Research on identifying psychological health problems of college students by logistic regression model based on data mining
Authors: Chen Qian 
Published: June 2022

Abstract
With the popularisation of education, the number of college students is increasing day by day, and there are also more students with psychological health problems. Whether students’ psychological abnormalities can be detected in time is one of the main problems faced by colleges and universities at present. Adopting digital technology to mine, collect and analyse the data generated by psychological health education in colleges can effectively solve the dynamic development of students’ psychological health problems. Therefore, in this paper, the psychological health problems of college students are identified and classified by establishing an improved logistic regression model. The behaviour characteristics are quantified and the differences are combined according to students’ relationships with their classmates, life rules and economic conditions. The test results show that the regression effect of the model is excellent, which can identify college students’ psychological health problems and improve the intervention and treatment of educators on students’ psychological problems.
Polyaniline Electrospun Composite Nanofibers Reinforced with Carbon Nanotubes
Authors: Yan Taohai , Shi Yajing , Cao Shengbin , Zhuang Huimin , Lin Yu , Zhu Lvtao , Lu Dongdong 
Published: June 2022

Abstract
Reinforcement of fibers was carried out by adding carbon black (CB), and hydroxylated and carboxylated carbon nanotubes (CNTs) into electrospinning solution containing doped polyaniline (CSA-PANI) and polyacrylonitrile (PAN). CB/CSA-PANI/PAN and CNT/CSA-PANI/PAN electrospun nanofiber composite membrane was formed in high-voltage electric field. The CSA-PANI/CB/PAN fiber membrane was found to be more brittle than the MWCNTs/CSA-PANI/PAN fiber membrane. The average diameter of the CSA-PANI/CB/PAN nanofibers increased with CB addition, while the average diameter of CNT-added MWCNTs/CSA-PANI/PAN nanofibers decreased with increasing CNT concentrations. Upon greater CB and CNT addition, agglomeration occurred, and the surface of the fibers was raised slightly. The fracture strength of the nanofiber membrane was greatly improved with 1% added CB but then decreased upon further CB addition. Upon addition of CNTs, the fracture strength of the nanofiber membrane first increased and then decreased, and the addition of carboxylated CNTs was more advantageous for improving the fracture strength of the fiber membrane. The electromagnetic shielding performance of the fiber membranes was essentially the same for different radiation frequencies. Upon addition of CB and CNTs, the electromagnetic shielding performance of the fiber first increased and then decreased, with a more pronounced decrease obtained by the addition of CB.
The Occurrence of Stereum hirsutum Associated with Wood Rotting of Olive Trees in Iran
Authors: Peighami Ashnaei Samira , Jafary Hossein , Afshari Azad Homayoun 
Published: June 2022

Abstract
In summer 2021 (June–July), disease symptoms on trunks and shoots were observed in olive groves in the Tarom Sofla region, Qazvin province, Iran. The symptoms were light-pink discoloration and surface depression in the external layers of the wood. As the disease progressed, brown streaks of tissue appeared on the longitudinal sections of the wood. The identification of fungus was made based on PCR amplification of the rDNA-ITS region with the universal fungal primers ITS5 and ITS4. BLAST searches revealed 99.52% identity to Stereum hirsutum. Several species of basidiomycetes are known to live on wood as saprobionts or parasites. On olive trees, they cause white rot symptoms. Although they are not directly responsible for tree mortality; however, they can lead to structural deterioration of woody tissues. To the best of our knowledge, this is the first report of S. hirsutum associated with wood rotting of olive trees in the world.
Better color distribution uniformity and higher luminous intensity for LED by using a three-layered remote phosphor structure
Authors: Loan Nguyen Thi Phuong , Anh Nguyen Doan Quoc , Trang Nguyen Cong , Lee Hsiao-Yi 
Published: June 2022

Abstract
Angular color distribution uniformity has been one of the most relevant properties in the development of white light-emitting diodes (WLEDs), since color consistency and uniformity are crucial factors in quality evaluation of a WLED. Here, particularly considering the need to overcome the poor chromaticity usually associated with WLED, we introduce a new design for the remote-phosphor package, namely a three-layered or triple-layer (TL) phosphor structure. Using three phosphor layers in packaging a WLED can result in higher color quality and luminous efficacy, compared to the double-layer (DL) configuration. In the present study, the results of using three remote phosphor layers indicate that although the structure using three layers has a lower color rendering index, the color quality scale is better than that available from the package with two layers. Additionally, the color-deviation values in the TL structure are smaller than in the dual-layer one, especially at high color temperatures (7,700 K and 8,500 K). Besides, in comparison with the DL model, the TL package increases the luminous flux by 1.4%–2%. Therefore, the TL remote phosphor structure possesses the greatest potential in enhancing the WLED quality.
Effect of electron beam irradiation on filtering facepiece respirators integrity and filtering efficiency
Authors: Chmielewska Dagmara , Werner Łukasz , Gryczka Urszula , Migdał Wojciech 
Published: June 2022

Abstract
The outbreak of the COVID-19 pandemic has shown that the demand for medical masks and respirators exceeds the current global stockpile of these items, and there is a dire need to increase the production capacity. Considering that ionizing radiation has been used for sterilization of medical products for many years and electron beam (EB) irradiation enables the treatment of huge quantities of disposable medical products in a short time this method should be tested for the mask’s decontamination. In this work, three different filtering facepiece respirators (FFRs) were irradiated with electron beams of 12 kGy and 25 kGy. The results confirmed that the decrease in filtration efficiency after irradiation of all respirators results from the elimination of the electric charge from the polypropylene (PP) fibers in the irradiation process. Moreover, the applied doses may affect the thermal stability of PP fabrics, while filtering materials structure and integrity have not changed after irradiation.
A bibliometric analysis of epidemiological studies investigating the relationship between community fluoridated water consumption and human cancers
Authors: Kanmodi Kehinde Kazeem , Ojo Temitope Oluwabukola , Nnyanzi Lawrence Achilles , Dorcas Alimi Oluwatunmise 
Published: June 2022

Objectives:
The objective of the study was to do a bibliometric analysis of epidemiological studies investigating the relationship between community fluoridated water consumption and human cancer occurrence.

Material and Methods:
A systematic PubMed and SCOPUS database search was done to collect articles of epidemiological studies investigating the relationship between community fluoridated water intake and human cancer occurrence. All relevant articles published in English, published from the year 2000 till November 23, 2021, and with accessible full text were obtained. Bibliometric data were obtained from each of these articles and analyzed using the Microsoft Office Excel 2021 (Microsoft Corporation, Washington DC, USA) software.

Results:
A total of 12 articles were obtained for this study. These articles investigated different cancer sites. The least investigated cancer sites were the eye (n = 1 article), lip (n = 1 article), and skin (n = 1 article), while the most investigated site was the bone (n = 8 articles). A total of 38 institutions sourced these epidemiological articles. The three institutions with the highest number of authors of these study articles were Harvard University (n = 6 authors), Moi University (n = 5 authors), and Newcastle University (n = 5 authors). Less than half (5/12) of these articles were funded. The UK was the country with the highest number of funding organizations on the research topic area.

Conclusion:
The volume of research investigating the relationship between community fluoridated water intake and cancer occurrence is very low, with zero output from several countries. Globally, the USA is the hottest spot for research on this topic area.