bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of the soil liquefaction on dynamic characteristics of a base-isolated structure investigated by the experimental method
Authors: Zhuang Haiyang , Liu Ying , Miao Yu , Zhao Chang , Xu Changjie , Chen Guoxing 
Published: November 2022

AbstractIn previous studies, the dynamic characteristics of a base-isolated structure on non-liquefied soil foundation have been investigated by some model tests. However, soil liquefaction can change the seismic responses of the base-isolated structure. In particular, due to the soil-structure interaction, the seismic-isolation layer of the structure is also bound to change the seismic responses of the pile foundation under the isolation layer, and then this also affect inversely the isolation performance of the isolated layer. However, this scientific problem has not been effectively studied. To investigate the seismic responses of a complex soil-pile-isolated structure interaction (SPISI) system after the soil foundation liquefied, a new shaking-table model test was designed. The test results were analysed and compared with a series of previous model tests on isolated structures with different non-liquefied soil foundations. As results, after the soil foundation liquefied, severe swing responses of the isolated structure and pile cap were observed. Then, the seismic responses of the pile were also changed evidently by the SPISI and severely aggravated by the strong swing responses of the isolated structure. Meanwhile, the foundation liquefaction also significantly weakened the isolation performance of the lead-rubber bearing and even amplified the horizontal acceleration response of the isolated structure. Because of the above SPISI effects, the dynamic characteristics and response laws of the isolated structure on a liquefied soil foundation are not consistent with those of base-isolated structures on non-liquefied soil foundations. On the contrary, they are similar to those of a non-isolated structure on the general soil foundation. At last, the test results are compared and verified by the numerical modelling.
The role of daughters in relation to their mother’s cervical cancer diagnosis and treatment in Guatemala: a descriptive study
Authors: Dau Hallie , Gottschlich Anna , Metz Lynn , Pineda Natalia , Pineda Andres , Alvarez Christian S. , Bevliacqua Kristin , Mendoza-Montano Carlos , Ogilvie Gina , Rivera-Andrade Alvaro , Gharzouzi Eduardo , Meza Rafael 
Published: November 2022

Abstract
PURPOSE
There is currently no information on how caregivers for women diagnosed with cervical cancer in Guatemala, particularly daughters, are affected by their supportive role. This study’s objective was to describe the support role of caregivers in the country, with a focus on daughters with a mother diagnosed with cervical cancer.
METHODS
This analysis utilizes data from a cross-sectional study which aimed to understand pathways to cervical cancer care. Women seeking cervical cancer treatment at the Instituto de Cancerologia (INCAN) in Guatemala City, Guatemala and their companions were surveyed. Descriptive statistics were calculated.
RESULTS
145 women seeking treatment and 71 companions participated in the study. Patient's daughters were most frequently reported as the person who provided the most support (51%) and as the most likely to have encouraged the patient to seek care. Furthermore, daughters were noted as the person most likely to fulfill the major household and livelihood roles of the patient while they were seeking or receiving treatment (38.0%). Most daughters reported that they were missing housework (77%), childcare (63%), and income-earning activities (60%) to attend the appointment with their mothers.
CONCLUSION
This study is the first to describe the support role of daughters of mothers receiving treatment for cervical cancer in Guatemala. The results suggests that daughters have a significant role in their mother’s cancer diagnosis and are often unable to participate in primary labor activities while providing support to the patient. This highlights an additional unexplored burden that cervical cancer has on women in Latin America.
Clinician perceptions of the impact of ICU family visiting restrictions during the COVID-19 pandemic: an international investigation
Authors: McPeake Joanne , Kentish-Barnes Nancy , Banse Emilie , Anderson Lynne , Cuzco Cecilia , Azoulay Elie , Quasim Tara , Castro Pedro , Puxty Kathryn 
Published: November 2022

Abstract
Background: To guarantee the safety of the public, clinicians and patients during the COVID-19 pandemic, hospital visits were severely restricted internationally. There is limited data on the precise impact of these visiting restrictions on Intensive Care Unit clinicians. Our objectives therefore were, to explore the impact of family visitation restrictions on clinicians and care and describe innovation and areas for potential improvement.
Methods: A qualitative approach, using focus groups was employed. We recruited members of the multi-disciplinary team from Spain, France and the UK. Framework analysis was used to synthesize and interpret data.
Results: In total, 28 staff from multiple international sites contributed to data across six focus groups: 12 from the UK, 9 from France and 7 from Spain. In relation to the key aims, we derived four themes: the emergence of new technologies; relationships and rapport establishment, communication challenges and end of life care provision. Across each theme, the overarching concepts of clinician emotional exhaustion and emotional distress emerged alongside the negative impact on job satisfaction.
Conclusion: The impact of COVID-19 family visitation restrictions is far reaching. Future research should examine the wider impact of family presence in the ICU.
The IBER study: a feasibility randomised controlled trial of Imagery Based Emotion Regulation for the treatment of anxiety in bipolar disorder
Authors: Steel Craig , Wright Kim , Goodwin Guy M. , Simon Judit , Morant Nicola , Taylor Rod S , Brown Michael , Jennings Susie , Hales Susie A. , Regan Jemma , Sibsey Michaela , Thomas Zoe , Meredith Lynette , Holmes Emily A. 
Published: November 2022

Abstract
Background: Intrusive mental imagery is associated with anxiety and mood instability within bipolar disorder and therefore represents a novel treatment target. Imagery Based Emotion Regulation (IBER) is a brief structured psychological intervention developed to enable people to use the skills required to regulate the emotional impact of these images.
Methods: Participants aged 18 and over with a diagnosis of bipolar disorder and at least a mild level of anxiety were randomly assigned (1:1) to receive IBER plus treatment as usual (IBER +TAU) or treatment as usual alone (TAU). IBER was delivered in up to 12 sessions overs 16 weeks. Clinical and health economic data were collected at baseline, end of treatment and 16-weeks follow-up. Objectives were to inform the recruitment process, timeline and sample size estimate for a definitive trial and to refine trial procedures. We also explored the impact on participant outcomes of anxiety, depression, mania, and mood stability at 16-weeks and 32-weeks follow-up.
Results: Fifty-seven (28: IBER+TAU, 27: TAU) participants from two sites were randomised, with 50 being recruited within the first 12 months. Forty-seven (82%) participants provided outcome data at 16 and 32-weeks follow-up. Thirty-five participants engaged in daily mood monitoring at the 32-week follow-up stage. Retention in IBER treatment was high with 27 (96%) attending ≥7 sessions. No study participants experienced a serious adverse event.
Discussion: The feasibility criteria of recruitment, outcome completion, and intervention retention were broadly achieved, indicating that imagery-focused interventions for bipolar disorder are worthy of further investigation.
Determinants of Climate Change Beliefs in Latin America
Authors: Spektor Matias , Fasolin Guilherme , Camargo Juliana 
Published: November 2022

Abstract
Policymakers struggle to come up with messages to effectively promote pro-climate political mobilization in the Global South. In order to identify what factors matter most in sensitizing public opinion in the developing world, this article highlights the main determinants of belief in the existence of climate change, its causes, and its consequences. We field surveys to nationally diverse samples in Argentina, Brazil, Colombia, Chile, Ecuador, Peru, and Mexico (N= 5338), a group of countries accounting for more than 80% of Latin America’s carbon emissions. We find that belief in the existence of climate change and its human causes is generalized, but there is no consensus around the severity of its consequences. Driving the skepticism is not political ideology but the presence of individualistic values, a worrisome conclusion in a region marked by relatively low levels of trust in political institutions and trust in others.
Associations of state or trait dissociation with severity of psychopathology in young people with borderline personality disorder
Authors: Salmon Ashleigh P. , Nicol Katie , Kaess Michael , Jovev Martina , Betts Jennifer K. , Chanen Andrew M. 
Published: November 2022

Abstract
Background
State and trait dissociation are associated with borderline personality disorder (BPD) severity and severity of commonly co-occurring mental health symptoms. Although these distinct constructs do not consistently co-occur in experimental settings, they are frequently reported as the same construct, namely dissociation. This study aimed to investigate the co-occurrence of state and trait dissociation among young people with BPD and to examine whether state or trait dissociation were associated with symptom severity in this population.
Methods
State dissociation was induced using a stressful behavioural task in a clinical sample of 55 young people (aged 15–25 years) with three or more BPD features. Diagnoses, state and trait dissociation, BPD severity and severity of posttraumatic stress disorder (PTSD), depressive, and stress symptoms were assessed by self-report or research interview.
Results
A chi-square test of independence showed a strong association between state and trait dissociation. Bonferroni corrected t-tests showed that state dissociation was significantly associated with PTSD symptom severity and likely associated with BPD severity and severity of depressive and stress symptoms. Trait dissociation was not associated with symptom severity or severity of BPD features.
Conclusions
These findings highlight the need to distinguish between state and trait dissociation in personality disorder research. They suggest that state dissociation might be an indicator of higher severity of psychopathology in young people with BPD.
Mixed Market Structure and R&amp;D: A Differential Game Approach
Authors: Yanase Akihiko , Long Ngo Van 
Published: November 2022

Abstract
We consider a dynamic model of an industry consisting of a few large firms, which can manipulate the market outcome, and a mass of small enterprises, each of which has a negligible impact on the market. The production costs of the respective firms depend on the stock of knowledge capital, which accumulates over time through research and development (R&D) investment made by large firms. The model is a variant of the differential game of voluntary provision of public goods, but in contrast to previous studies, we focus on the interaction between market competition and dynamic game outcomes. We derive both open-loop and Markov-perfect Nash equilibria. There exists a unique open-loop Nash equilibrium. By contrast, depending on the parameters of the model, there can be two linear Markov-perfect Nash equilibria. We also examine the short- and long-run effects of a change in the number of large firms. An increase in the number of large firms unambiguously harms both types of firms in the short run but may benefit them in the long run. In the open-loop Nash equilibrium, the relationship between the number of large firms and the steady-state stock of knowledge capital is inverted-U shaped. Concerning the Markov-perfect Nash equilibria, the effect of increased competition from large firms depends on the specific feedback strategy chosen in equilibrium.
JEL classification: C61; C72; C73; D43; H41; L13
The rapid detection of respiratory pathogens in critically ill children
Authors: Clark John Alexander , Morris Andrew Conway , Curran Martin D , White Deborah , Daubney Esther , Kean Iain RL , Navapurkar Vilas , Scott Josefin Bartholdson , Maes Mailis , Bousfield Rachel , Török M. Estée , Inwald David , Zhang Zhenguang , Agrawal Shruti , Kanaris Constantinos , Khokhar Fahad , Gouliouris Theodore , Baker Stephen , Pathan Nazima 
Published: November 2022

Abstract
Purpose
Respiratory infections are the most common reason for admission to Paediatric Intensive Care Units (PICU). Most patients with lower respiratory tract infection (LRTI) receive broad-spectrum antimicrobials, despite low rates of bacterial culture confirmation. Here, we evaluated a molecular diagnostic test for LRTI to inform the better use of antimicrobials.
Methods
The Rapid Assay for Sick Children with Acute Lung infection Study (RASCALS) was a single-centre, prospective, observational cohort study of mechanically ventilated children (> 37/40 weeks corrected gestation to 18 years) with suspected community acquired or ventilator-associated LRTI. We evaluated the use of a 52-pathogen custom TaqMan array card (TAC) to identify pathogens in non-bronchoscopic bronchoalveolar lavage (mini-BAL) samples. TAC results were compared to routine microbiology testing. Primary study outcomes were sensitivity and specificity of TAC, and time to result.
Results
We enrolled 100 patients; all of whom were tested with TAC and 91 of whom had matching culture samples. TAC had a sensitivity of 89.5% (95% confidence interval (CI95) 66.9–98.7) and specificity of 97.9% (CI95 97.2–98.5) compared to routine bacterial and fungal culture. TAC took a median 25.8 hours (IQR 9.1–29.8 hours) from sample collection to result. Culture was significantly slower; median 110.4 hours (IQR 85.2–141.6 hours) for a positive result and median 69.4 hours (IQR 52.8–78.6) for a negative result.
Conclusions
TAC is a reliable and rapid adjunct diagnostic approach for LRTI in critically ill children, with the potential to aid early rationalisation of antimicrobial therapy.
Differences of gene regulation by TLR3 and IPS-1 in polyI:C-stimulated murine corneal epithelial cells
Authors: Komai Seitaro , Ueta Mayumi , Nishigaki Hiromi , Mizushima Katsura , Naito Yuji , Kinoshita Shigeru , Sotozono Chie 
Published: November 2022

Abstract
Toll-like receptor 3 (TLR3) and interferon-beta promoter stimulator-1 (IPS-1) are associated with antiviral responses to double-stranded RNA viruses and contribute to innate immunity. We previously reported that conjunctival epithelial cell (CEC) TLR3 and IPS-1 pathways respond to the common ligand polyinosinic:polycytidylic acid (polyI:C) to regulate different gene expression patterns as well as CD11c + cell migration in murine-model corneas. However, the differences in the functions and the roles of TLR3 and IPS-1 remain unclear. In this study, we investigated the differences of TLR3 or IPS-1-induced gene expression in corneal epithelial cells (CECs) in response to polyI:C stimulation using cultured murine primary CECs (mPCECs) derived from TLR3 and IPS-1 knockout mice via comprehensive analysis. The genes associated with viral responses were upregulated in the wild-type mice mPCECs after polyI:C stimulation. Among these genes, Neurl3, Irg1, and LIPG were dominantly regulated by TLR3, while interleukin (IL)-6 and IL-15 were dominantly regulated by IPS-1. CCL5, CXCL10, OAS2, Slfn4, TRIM30α, and Gbp9 were complementarily regulated by both TLR3 and IPS-1. Our findings suggest that CECs may contribute to immune responses and that TLR3 and IPS-1 possibly have different functions in the corneal innate immune response.
Water-sulfur-rich, oxidised adakite magmas are likely porphyry copper progenitors
Authors: Leong Timothy Sung Jue , Mavrogenes John Ashby , Arculus Richard James 
Published: November 2022

Abstract
The world’s largest current Cu resource is volcanic arc-hosted, porphyry copper deposits. Whether unusual parental magmas or fortuitous combinations of processes accompanying emplacement of common parental arc magmas (e.g., basalt) is required for ore deposit formation, remains unclear. Spatial and tectonic associations of adakite (andesite with high La/Yb, Sr/Y) with porphyries exist, but genetic links are debated. Delayed saturation with Cu-bearing sulfides consequent to elevated redox state seems essential for late-stage exsolution of Cu-bearing hydrothermal fluids. Partial melting of igneous layers of subducted, hydrothermally altered oceanic crust in the eclogite stability field are invoked to account for andesitic compositions, residual garnet signatures, and the putative oxidised character of adakites. Alternative petrogeneses include partial melting of lower crustal, garnet-bearing sources and extensive intra-crustal amphibole fractionation. Here we demonstrate mineral-hosted, adakite glass (formerly melt) inclusions in lavas erupted subaqueously in the New Hebrides arc are oxidised relative to island arc (and mid-ocean ridge) basalts, are H2O-S-Cl-rich, and moderately enriched in Cu. Polynomial fitting of chondrite-normalised, rare earth element abundance patterns shows the precursors of these erupted adakites were unequivocally derived from partial melting of subducted slab, and represent optimal porphyry copper progenitors.
Clostridium aromaproducens sp. nov., isolated from pit mud used for producing Wuliangye baijiu
Authors: Luo Qingchun , Zheng Jia , Zhao Dong , Liu Duotao 
Published: November 2022

Abstract
A strictly anaerobic, gram-positive bacterium, designated as WLY-B-L2T, was isolated from pit mud of a fermentation pit located at Wuliangye 501# baijiu workshop in Yibin (Sichuan province, PR China). The strain has straight or somewhat rod-shaped cells, which are 0.5–0.7 µm wide and 1.7–3.1 µm long, arranged singly or in pairs. The strain can produce butyric acid and utilize D-galacturonic acid, methyl pyruvate, L-lactamine, L-alanyl-L-glutamine, L-alanyl-L-histidine, glycerol, pyruvate, L-alanyl-L-threonine, L-methionine, L-phenylalanine, L-valine + L- aspartic acid, L-serine, L-valine, and thymidine as carbon sources. Major cellular fatty acids are C16: 0 (24.6%), anteiso-C15: 0 (16.5%), and iso-C15: 0 (14.1%). Based on 16S rRNA gene sequence, WLY-B-L2T is most closely related to Clostridium luticellarii FW431T; they exhibit 97.42% 16S rRNA similarity. Additionally, the digital DNA-DNA hybridization (dDDH) value between them is 28.10%. WLY-B-L2T has a G + C content of 34.16 mol%. Based on the evidence presented here, WLY-B-L2T (CICC 25133T = JCM 35127T) is proposed as the type strain of a novel species, designated as Clostridium aromatiproducens sp. nov.
Improvement of water quality with probiotics inclusion during simulated transport of yellowfin seabream (Acanthopagrus latus) larvae
Authors: Gamoori Reza , Rashidian Ghasem , Ahangarzadeh Mina , Najafabadi Mojtaba , Dashtebozorg Mehdi , Mohammadi Yaghoob , Morshedi Vahid 
Published: November 2022

Abstract

The effects of using a commercial probiotic mixture (PM) (Bacillus licheniformis, Bacillus sabtilis, Pedicoccus acidilactici and Lactobacillus acidophilus with a total count of 107 CFU/g) on water quality, bacterial population and the survival of Acanthopagrus latus larvae were evaluated during a 24-hour simulated transportation experiment. The one-day-old larvae were transported using purified seawater (as control) and purified seawater supplemented with 3 g of PM (as PM48 treatment). For the PM48, 3 g of PM was added to 1 L of purified seawater and after 30 min, mixed with 200L of purified seawater 48h prior to the main experiment. The obtained results showed that the use of probiotics led to an increase in larval survival up to 93.3%. Statistically, difference was found between control and PM48 at the initial sampling in terms of NO2. The pH of the control treatment showed a significant decrease at the end of the experiment. The investigation of a total number of bacteria and the total number of Vibrio spp. in water and fish larvae showed that within 48 hours, the probiotics became the dominated population in PM48 treatment. After 24 hours, water samples and larvae of control treatment showed a significant increase in bacterial load. In general, the obtained results showed that the use of probiotics played a significant role in maintaining water quality chemically and bacterially and caused more survival of larvae during transportation.
Assessment of Nitrogen fertigation and plant spacing in Chrysanthemum (Chrysanthemum morifolium Ramat.) cv. Ratlam selection.
Authors: Vimal Vimal Bhobhria , Bala Madhu Bala Madhu , singh Parminder Singh Parminder , Sharda Rakesh Sharda Rakesh 
Published: November 2022

AbstractThe investigations entitled “Studies on plant spacing and fertigation schedule for loose flower production of chrysanthemum (Chrysanthemum morifoliumRamat.)” was carried out at Research Farm, Department of Floriculture and Landscaping and Soil and Water Engineering, PAU, Ludhiana during the year 2021-22 with the aim to standardize fertigation level and plant spacing for quality loose flower production. Four different fertigation levels of N@ (60kg/ha, 80kg/ha, 100kg/ha and 120kg/ha) were applied chrysanthemum varietiy namely ‘Ratlam Selection’ through drip irrigation along with three different spacings i.e., 40×30 cm, 40×40 cm and 40×60 cm. The statistical used was Split Plot Design (SPD) and trial was replicated thrice.The data on growth, flowering and yield parameters were recorded and statistically analysed. The data on growth, floral attributes, plant spread (46.70), number of branches (7.80) least days to first flower bud initiation (82.92 days), flower weight (3.22 gm) and highest chlorophyll content (58.57 spad value) was recorded with the application of N@ 120 kg/ha− 1with planting distance of 40×60 cm and the maximum flower diameter (7.71 cm) and flowers/plant (138.67) was recorded higher with the application of N@ 100 kg/ha− 1with planting distance of 40×60 cm.. Yield attributes such as flowers weight per unit area (m2), number of flowers per unit area (m2), were recorded best with treatment N@ 100kg/ha with plant spacing 40×60 cm. Based on the study it can be concluded that fertigation level N@ 100kg/ha was found to be the most suitable for quality production of loose flowers of chrysanthemum with spacing 40×30 cm.