bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prototyping of Straight Section Components Using Incremental Shape Rolling
Authors: Essa Abdelrahman , Abeyrathna Buddhika , Rolfe Bernard , Weiss Matthias 
Published: January 2022

Abstract
Flexible Roll Forming (FRF) allows the forming of components with a variable cross-section along the length of the component. However, the process has only limited application in the automotive industry due to wrinkling in the flange which currently prevents the forming of high strength steels and limits the part shape complexity. This paper presents a new forming technology, Incremental Shape Rolling (ISR), where a pre-cut blank is clamped between two dies and then a single forming roll is used to incrementally form the material to the desired shape. The new process is similar to some Incremental Sheet Forming (ISF) approaches but with the difference that Incremental Shape Rolling (ISR) allows the manufacture of longitudinal components from high strength metal sheets. In this work, a numerical model of the ISR of a straight section is developed. Experimental prototyping trials are performed and are used to validate the numerical model which is then applied to analyse the new forming process. The results show that in ISR, tensile residual strains are developed in the flange. Flange wrinkling is observed and directly linked to the number of forming passes that are used in the process.
Machine-learning and Automatically Segmented Retinal Biomarkers Generate Spatial Heatmaps Predictive for Standard and Low Luminance Visual Acuity in Geographic Atrophy
Authors: Balaskas Konstantinos , Glinton Sophie , Keenan Tiarnan , Faes Livia , Liefers Bart , Zhang Gongyu , Pontikos Nikolas , Struyven Robbert , Wagner Siegfried , McKeown Alex , Patel Praveen , Keane Pearse , Fu Dun Jack 
Published: January 2022

Abstract
Objective: Predict visual function with machine-learning applied to automatically acquired quantitative imaging biomarkers in geographic atrophyDesign: Post-hoc analysis of data from a clinical trial and routine clinical care.Methods: Automated segmentation of OCT scans from 476 eyes (325 patients) with geographic atrophy. Machine learning modelling of resultant quantitative OCT (qOCT) biomarkers to predict cross-sectional visual acuity under both standard luminance (VA) and low luminance (LLVA) conditions.Main Outcome Measure: Correlation coefficient (R2) and mean absolute error (MAE) for cross-sectional VA and LLVA in Early Treatment Diabetic Retinopathy Study (ETDRS) letters.Results: Best-corrected VA under both standard luminance (R2 0.46 MAE 10.2 ETDRS letters) and low-luminance conditions (R2 0.25 MAE 12.1) could be predicted. The foveal region contributed the most (46.5%) toward model performance, with retinal pigment epithelium loss and outer retinal atrophy contributing the most (31.1%). For LLVA, however, features in the non-foveal regions were most important (74.5%), led by photoreceptor degeneration (38.9%).Conclusions: Our method of automatic qOCT segmentation demonstrates functional significance for vision in geographic atrophy, including LLVA. LLVA is itself predictive of geographic atrophy progression, implying that the predictive qOCT biomarkers provided by our model are also prognostic.
Diaphragmatic Compound Muscle Action Potentials Recorded From Over the Sternum and Lateral Chest Wall: a Comparative Study
Authors: Younis Gihan , EL-Sawy Noha , Elnemr Rehab , Madkour Doaa 
Published: January 2022

Abstract
Objectives:To report normative data for diaphragmatic compound muscle action potentials (DCMAPs) recorded from over the sternum and lateral chest wall (LCW).Method:The phrenic nerve of seventy-three healthy subjects was bilaterally stimulated at the posterior border of the sternocleidomastoid muscle. DCMAPs from over the sternum and LCW were recorded (inspiration/expiration). Results: Normative values of sternal and LCW DCMAPs were presented. Significant differences were found between sternal and LCW potentials in the mean latency, amplitude, and area (p<0.001). The duration did not differ between the two sites. Differences were found between inspiration and expiration, right and left sides, and men and women. Regression analysis showed a relation between latency of sternal and LCW potentials and age. Latency (LCW potentials) and amplitude and area (sternal/LCW potentials) were related to gender. Amplitude (LCW potentials/inspiration) and area (sternal potentials/inspiration) were related to chest circumference (p=0.023 and 0.013 respectively). Area (sternal potentials/expiration) was related to the BMI (p=0.019). Conclusions: Our normative values for sternal and LCW DCMAPs are provided. Notable differences in the DCMAPs parameters were detected between the two recording sites, inspiration and expiration, right and left, and men and women. Significance:The technique of phrenic nerve should be standardized.
Slipped Capital Femoral Epiphysis Associated With Hypogonadism: A Case Report And Literature Review
Authors: Kitagawa Sachiko , Wakabayashi Kenjiro , Azuma Yoshiteru , Kurahashi Hirokazu , Takazawa Kei , Kashimada Kenichi , Takagi Junko , Yamamoto Toshiyuki , Akihisa Okumura , Iwayama Hideyuki 
Published: January 2022

Abstract
Background: Slipped capital femoral epiphysis (SCFE) is a displacement of the femoral head epiphysis that is sometimes associated with endocrinopathies. We report the case of a 12-year-old girl with hypergonadotropic hypogonadism (HH) who developed SCFE during growth hormone therapy (GHT). We also performed a systematic review of the cases of SCFE and hypogonadism in the literature. Case presentation: The patient was diagnosed with HH based on the absence of ovaries and a uterus. Her medical history included GHT for 9 years as she was small for gestational age. Chromosomal and genetic analyses revealed no pathogenic abnormalities. Radiographs revealed a left SCFE with a 28.7° posterior tilt angle. GHT was discontinued, and bilateral in situ screw fixation was performed. Sex hormone therapy (SHT) was initiated. Two years later, the patient recovered.Methods: We reviewed the cases of hypogonadism complicated with SCFE. The guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 statement were followed. Case reports of patients were retrieved using PubMed on November 17, 2021.Results: A total of 44 cases of SCFE and hypogonadism were identified, including this case. Endocrinological complications included growth hormone deficiency (n = 18), being overweight (n = 9), and hypothyroidism (n = 25). Hormone replacement was administered before (SHT, n = 6; GHT, n = 12) and after surgery (SHT, n = 21; GHT, n = 11). SCFE surgery was invasive (minimal, n = 19; moderate, n = 10; high, n = 8). Orthopedic complications were observed in four cases. Conclusions: If hypogonadism occurs during GHT, SCFE should be noted. Hypogonadism should be studied to determine the effects of hormonal replacement on SCFE.
Prenatal Stress Selectively Impairs Neuroligin 1-Dependent Neurogenesis by Suppressing Astrocytic FGF2-Neuronal FGFR1 Axis
Authors: Choi Gee Euhn , Chae Chang Woo , Park Mo Ran , Yoon Jee Hyeon , Jung Young Hyun , Lee Hyun Jik , Han Ho Jae 
Published: January 2022

Abstract
Exposure to maternal stress irreversibly impairs neurogenesis of offspring through inducing life-long effects on interaction between neurons and glia under raging differentiation process, culminating in cognitive and neuropsychiatric abnormalities in adulthood. We identified how prenatal exposure to the stress-hormone glucocorticoid impairs synapse formation and subsequent neurogenesis using human induced pluripotent stem cell (iPSC)-derived neural stem cell (NSC) and ICR mice. Following prenatal glucocorticoid exposure, NSC-derived astrocytes were found to be A1-like neurotoxic astrocytes. Moreover, cortisol-treated astrocyte conditioned media (ACM) then specifically downregulated AMPA receptor-mediated glutamatergic synaptic formation and transmission in differentiating neurons, by inhibiting localization of ionotropic glutamate receptor (GluR) 1/2 into synapses. We revealed that downregulated astrocytic fibroblast growth factor 2 (FGF2) and nuclear fibroblast growth factor receptor 1 (FGFR1) of neurons are key pathogenic factors for reducing glutamatergic synapse formation, according to data from RNA sequencing and antibody array. We further confirmed that cortisol-treated ACM specifically decreased the binding of neuronal FGFR1 to the synaptogenic NLGN1 promoter, but this was reversed by FGFR1 restoration. Upregulation of neuroligin 1, which is important in scaffolding GluR1/2 into the postsynaptic compartment, eventually normalized glutamatergic synaptogenesis and subsequent neurogenesis. Moreover, FGF2 pretreatment of a prenatal corticosterone-exposed mouse elevated neuroligin 1 expression and trafficking of GluR1/2 into the postsynaptic compartment, improving spatial memory and depression/anxiety-like behaviors. In conclusion, we demonstrated that neuroligin 1 restoration by astrocytic FGF2 and its downstream neuronal nuclear FGFR1 as a critical target of prenatal stress-induced glutamatergic synaptogenesis and demonstrated its function in controlling both neurogenesis and hippocampal-related behaviors.
A New Way to Compute the Lyapunov Characteristic Exponents for Non-Smooth and Discontinues Dynamical Systems
Authors: Semenov Mikhail E. , Borzunov Sergei V. , Meleshenko Peter A. 
Published: January 2022

Abstract
One of the most important problems of nonlinear dynamics is related to the development of methods concerning the identification of the dynamical modes of the corresponding systems. The classical method is related to the calculation of the Lyapunov characteristic exponents ( LCEs ). Usually, to implement the classical algorithms for the LCEs calculation the smoothness of the right-hand sides of the corresponding equations is required. In this work, we propose a new algorithm for the LCEs computation in systems with strong nonlinearities (these nonlinearities can not be linearized ) including the hysteresis. This algorithm uses the values of the Jacobi matrix in the vicinity of singularities of the right-hand sides of the corresponding equations. The proposed modification of the algorithm is also can be used for systems containing such design hysteresis nonlinearity as the Preisach operator (thus, this modification can be used for all members of the hysteresis family). Moreover, the proposed algorithm can be successfully applied to the well-known chaotic systems with smooth nonlinearities . Examples of dynamical systems with hysteresis nonlinearities , such as the Lorentz system with hysteresis friction and the van der Pol oscillator with hysteresis block, are considered. These examples illustrate the efficiency of the proposed algorithm.
Vital signs of severe COVID-19 patients during inter-hospital helicopter transfer
Authors: Slagt Cornelis , Spoelder Eduard Johannes , Tacken Marijn Cornelia Theresia , Frijlink Maartje , Servaas Sjoerd , Leijte Guus , Eijk Lucas Theodorus , Geffen Geert Jan 
Published: January 2022

Abstract
Background: During the COVID-19 pandemic in The Netherlands, critically ill ventilated COVID-19 patients were transferred not only between hospitals by ambulance but also by the Helicopter Emergency Medical Service (HEMS). To date, little is known about the impact of helicopter transport on critically ill patients and COVID-19 patients in particular. This study was conducted to explore the impact of inter-hospital helicopter transfer on vital signs of mechanically ventilated severe COVID-19 intensive care patients, with special focus on take-off, midflight, and landing.Methods: All ventilated critically ill COVID-19 patients who were transported between April 2020 and June 2021 by the Dutch ‘Lifeliner 5’ HEMS team and who were fully monitored, including noninvasive cardiac output, were included in this study. Three 10-minute timeframes (take-off, midflight and landing) were defined for analysis. Continuous data on the vital parameters heart rate, peripheral oxygen saturation, arterial blood pressure, end-tidal CO2 and noninvasive cardiac output using electrical cardiometry were collected and stored at 1-minute intervals. Data were analydzed for differences over time within the timeframes using 1-way analysis of variance. Significant differences were checked for clinical relevance.Results: Ninety-eight patients were included in the analysis. During take-off, an increase was noticed in cardiac output (from 6.7 to 8.1 Lmin-1; P<0.0001), which was determined by a decrease in systemic vascular resistance (from 1068 to 750 dyne·s·cm−5, P<0.0001) accompanied by an increase in stroke volume (from 92.0 to 110.2 ml, P<0.0001). Other parameters were unchanged during take-off and mid-flight. During landing, cardiac output and stroke volume slightly decreased (from 7.9 to 7.1 Lmin-1, P<0.0001 and from 108.3 to 100.6 ml, P<0.0001, respectively), and total systemic vascular resistance increased (P<0.0001). Though statistically significant, the found changes were small and not clinically relevant to the medical status of the patients as judged by the attending physicians.Conclusions: Interhospital helicopter transfer of ventilated intensive care patients with COVID-19 can be performed safely and does not result in clinically relevant changes in vital signs.This study was assessed by the medical ethical committee Arnhem-Nijmegen, the Netherlands (identifier 2021-7313). The committee waived the need for informed consent. The study was registered at www.trialregister.nl (identifier NL9307).
Isolation of Unusual N-Thiophenyl Ebselenamines and other Intermediates during the 77Se NMR Mechanistic Study of Azo-Bis-Ebselen: Their Antioxidant Behaviour against Oxidative Stress
Authors: KUMAR MANISH , SINGH VIJAY P. 
Published: January 2022

Abstract
Based on the traditional 77Se NMR spectroscopy investigation, a catalytic cycle for the formation of N-thiophenyl ebselenamine 12 involving diselenide 9, selenenyl sulfide 10 and ebselenamine 7a was reported by the reaction of azo-bis-ebselen 8 with PhSH and H2O2. The signals detected in the 77Se NMR spectrum corresponding to 7a, 10 and 12 were directly isolated from the NMR mixture. Mechanistic investigation for the formation of N-thiophenyl ebselenamine 12 was confirmed from an independent reaction of diselenide 9 and PhSSPh in the presence of H2O2. This was further supported by another diselenide 19 containing p-tolyl group with equimolar amount of H2O2 and PhSH in an independent experiment followed by the 77Se NMR spectroscopy, yielding similar observations. These results, which illustrated diselenide has been observed as the main precursor in the formation of all intermediates. The new novel selenium antioxidants quenched lipidperoxyl radicals much more efficiently than α-tocopherol and were regenerable by the aqueous ascorbic acid in a two-phase (chlorobenzene/water) azo-initiated peroxidation system. The notable benefit of the organoselenium biology, the novel ebselenamine analogues and their corresponding selenenyl sulfides were found to mimic the activity of the glutathione peroxidase enzymes better than ebselen in the coupled reductase assay.
Customized Mobile App for Residents Rotating Through Pediatric Critical Care Unit
Authors: Tseng Yu-shan , Thomas Ronald , Sarnaik Ajit 
Published: January 2022

Abstract
Introduction: Physicians use mobile apps for patient care, but few are dedicated to pediatric critical care medicine (PCCM). We developed an easy-to-use customized mobile app for PCCM residents. Our objectives were to evaluate whether this mobile app will improve residents' confidence in PCCM knowledge and comfort level in the pediatric intensive care unit (PICU).Methods: We recruited 90 residents from March 2020 to April 2021 for this prospective survey-based, block-randomized, single-center study with a pre-post study design. Participants completed 20-question quizzes at the beginning and end of the rotation. T-test was used to compare the pre-post quiz score difference between the two groups of residents (those with and without the app). At the end of the rotation, subjects also completed a survey with 5-point Likert scale items to compare their comfort level in PICU and confidence in PCCM knowledge pre- and post-rotation.Results: There was a significantly increased improvement in the post-block quiz from the pre-block quiz in the mobile app group compared to the control group (an increase of 0.23 questions vs 1.67, p=0.045). There was a trend of increased improvement in confidence in pediatric critical care knowledge for the App group; however, the difference did not reach statistical significance by Pearson's Chi-square test (p=0.246). Similarly, there was no statistical difference between the two study groups for change in Comfort Level in PICU from the baseline level.Conclusion: Implementation of a service-specific mobile app may enhance residents' clinical experience and improve self-efficacy. Further investigation is warranted.
The Role of the Serum 25-OH Vitamin D Level in Detecting Prostate Cancer in Men with Elevated Prostate-Specific Antigen Levels
Authors: Kim Min Hyuk , Yoo Sangjun , Choo Min Soo , Cho Min Chul , Son Hwancheol , Jeong Hyeon 
Published: January 2022

Abstract
We aimed to determine whether vitamin D levels before prostate biopsy have diagnostic value for clinically significant prostate cancer. The study cohort included patients who underwent prostate biopsy. A total of 224 patients were enrolled in our study, and serum vitamin D levels were measured from February 2016 to December 2019 in routine laboratory tests. To determine the relationship between vitamin D levels and the aggressiveness of prostate cancer, we used multivariate analysis. Based on the histopathological results, the serum vitamin D level was marginally lower in the group with higher positive cores and pT3 or higher, and the serum vitamin D level was significantly lower in the large tumor volume group. In the univariate analysis, the prostate cancer diagnosis rate was associated with low vitamin D levels. In clinically significant prostate cancer diagnosis, low vitamin D levels were found in the univariate (odds ratio [OR], 0.955; P<0.001) and multivariate (OR, 0.944; P=0.027) analyses. In conclusion, we found that the incidence of prostate cancer tends to increase as the vitamin D level is lower in the Asian population, and this is particularly helpful in diagnosing clinically significant prostate cancer.
Malignancy Risk Stratification of Thyroid Nodules According to Echotexture and Degree of Hypoechogenicity: A Multicenter Validation Study
Authors: Lee Ji Ye , Lee Chang Yoon , Hwang Inpyeong , You Sung-Hye , Park Sun-Won , Lee Boeun , Yim Younghee , Kim Ji-hoon , Na Dong Gyu 
Published: January 2022

Abstract
Purpose Various risk stratification systems show some discrepancies in the ultrasound (US) lexicon of nodule echotexture and hypoechogenicity. This study aimed to determine the malignancy risk of thyroid nodules according to their echotexture and degree of hypoechogenicity in a multicenter dataset.Methods From June to September 2015, 5,601 thyroid nodules (≥ 1.0 cm) in 4,989 consecutive patients who underwent thyroid US and with a final diagnoses from 26 institutions were evaluated. Thyroid nodules were stratified according to the US echotexture (homogeneous vs. heterogeneous) and degree of hypoechogenicity (mild, moderate, or marked). We then calculated malignancy risk and compared four subgroups stratified with nodule composition and presence of suspicious features.Results Heterogeneous hypoechoic nodules showed a significantly higher malignancy risk than heterogeneous isoechoic nodules (P ≤ 0.017) except in partially cystic nodules. There was no significant difference in malignancy risk between homogeneous vs. heterogeneous hypoechoic nodules (P ≥ 0.086) and between homogeneous vs. heterogeneous iso- or hyperechoic nodules (P ≥ 0.05) except in partially cystic nodules without suspicious features. The malignancy risks of both homogeneous and heterogeneous iso- or hyperechoic nodules were low to intermediate, depending on the presence of suspicious features. Regarding the degree of hypoechogenicity, there was no significant difference in malignancy risk between markedly and moderately hypoechoic nodules in all subgroups (P ≥ 0.48). Marked or moderately hypoechoic nodules showed a significantly higher risk than mild hypoechoic (P ≤ 0.016) and iso- or hyperechoic (P < .001) nodules. Conclusions The predominant echogenicity effectively stratifies the malignancy risk of nodules with heterogeneous echotexture. For malignancy risk stratification, the degree of nodules’ hypoechogenicity could be grouped as mild vs. moderate to marked hypoechogenicity.
The Effect of Diabetes and the Diabetogenic TBC1D4 p.Arg684Ter Variant on Kidney Function in Inuit in Greenland
Authors: Overvad Maria , Diaz Lars Jorge , Bjerregaard Peter , Pedersen Michael Lynge , Larsen Christina Viskum Lytken , Grarup Niels , Hansen Torben , Rossing Peter , Jørgensen Marit Eika 
Published: January 2022

Abstract
ObjectiveDiabetes prevalence in Greenland is high and increasing. The aim of this study was to examine the effect of diabetes and the diabetogenic TBC1D4 variant on kidney function in Greenland in a population-based setting.Research Design and MethodsHealth survey data and TBC1D4 genotypes from 5,336 Greenlanders was used to estimate odds ratios (ORs) of albuminuria (>30 mg/g creatinine) and chronic kidney disease (CKD, eGFR<60 ml/min/1.73m2), comparing individuals with and without diabetes. Using baseline and follow-up data from individuals who participated in two surveys we examined the effect of diabetes on eGFR and urinary albumin creatinine ratio (UACR) at follow-up, stepwise adjusting for baseline confounders including the TBC1D4 variant.ResultsA total of 9.3% had diabetes of the 3,909 participants with complete data. Albuminuria and CKD was found in 27.6% and 9.5% among those with and without diabetes respectively. Diabetes was associated with increased risk of albuminuria (OR(95% CI) = 2.37 (1.69,3.33) p<0.001) and the TBC1D4 variant protected against albuminuria (OR(95% CI) = 0.44 (0.22,0.90) p=0.02) in a multivariable model. Neither diabetes nor the TBC1D4 variant significantly associated with CKD. Diabetes was not associated with changes in eGFR or UACR over a median of 11.3 years.ConclusionDiabetes conferred increased risk of albuminuria and the TBC1D4 variant was associated with decreased risk of albuminuria, but neither were associated with CKD. The presence/absence of diabetes did not predict changes in eGFR and UACR in longitudinal analyses. The potential renoprotective association of the TBC1D4 variant on albuminuria calls for further studies.