bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of colchicine for the treatment of osteoarthritis: a systematic review and meta-analysis of intervention trials
Authors: Singh Ambrish , Molina-Garcia Pablo , Hussain Salman , Paul Alok , Das Siddharth Kumar , Leung Ying-Ying , Hill Catherine L. , Danda Debashish , Samuels Jonathan , Antony Benny 
Published: October 2022

Abstract

Objective
Colchicine, an approved treatment for gout, has been trialed in many diseases including osteoarthritis (OA) due to its anti-inflammatory effects. However, its efficacy and safety remain unclear in OA. This systematic review and meta-analysis evaluated the efficacy and safety of colchicine for the treatment of OA.

Methods
PubMed, Web of Science, Scopus, and Cochrane Central were searched from inception through September 2022. Two reviewers independently screened for randomized controlled trials (RCTs) comparing colchicine with placebo or other active comparators for the treatment of OA (knee, hand, or hip OA), extracted data, and performed Cochrane risk of bias assessments.

Result
Nine RCTs for the knee OA and one for the hand OA were identified, consisting of 847 patients (429 in colchicine arms, 409 in control arms). The studies were conducted between 2002 and 2021 with follow-up periods ranging from 2 to 12 months, in India, Iran, Turkey, Australia, Singapore, and Iraq. Moderate-quality evidence showed no clinically important pain reduction with colchicine compared to control (standardized mean difference [SMD], 0.17; 95% confidence interval [CI], − 0.55, 0.22). Moderate-quality evidence showed no improvement in function with colchicine compared to control in knee OA patients (SMD, − 0.37; 95% CI, − 0.87, 0.13). Colchicine showed an acceptable safety profile with AEs/SAEs comparable to control.

Conclusion
Current evidence does not suggest a benefit of colchicine in reducing pain and improving physical function in the overall cohort of hand/knee OA patients. Future trials should focus on the subgroups of OA patients with local or systemic inflammation and/or mineralization who might benefit from colchicine.

Graphical abstract

Key Points•Colchicine is an approved treatment for gout that has been trialed in many diseases including osteoarthritis (OA) due to its anti-inflammatory effects. However, the benefit and harms of colchicine in OA remain unclear.• Current evidence from randomized control trials does not suggest a benefit of colchicine in reducing pain and improving physical function for the treatment of OA patients.• Future trials of colchicine in OA should focus on the subgroups of OA patients with local or systemic inflammation and/or mineralization who might benefit from colchicine.
Life is in motion (through a chick’s eye)
Authors: Lemaire Bastien S. , Vallortigara Giorgio 
Published: October 2022

AbstractCognitive scientists, social psychologists, computer scientists, neuroscientists, ethologists and many others have all wondered how brains detect and interpret the motion of living organisms. It appears that specific cues, incorporated into our brains by natural selection, serve to signal the presence of living organisms. A simple geometric figure such as a triangle put in motion with specific kinematic rules can look alive, and it can even seem to have intentions and goals. In this article, we survey decades of parallel investigations on the motion cues that drive animacy perception—the sensation that something is alive—in non-human animals, especially in precocial species, such as the domestic chick, to identify inborn biological predispositions. At the same time, we highlight the relevance of these studies for an understanding of human typical and atypical cognitive development.
Analysis of PMMA versus CaP titanium-enhanced implants for cranioplasty after decompressive craniectomy: a retrospective observational cohort study
Authors: Wesp Dominik , Krenzlin Harald , Jankovic Dragan , Ottenhausen Malte , Jägersberg Max , Ringel Florian , Keric Naureen 
Published: October 2022

Abstract

Numerous materials of implants used for cranioplasty after decompressive craniectomy (DC) have been investigated to meet certain demanded key features, such as stability, applicability, and biocompatibility. We aimed to evaluate the feasibility and safety of biocompatible calcium-phosphate (CaP) implants for cranioplasty compared to polymethylmethacrylate (PMMA) implants. In this retrospective observational cohort study, the medical records of all patients who underwent cranioplasty between January 1st, 2015, and January 1st, 2022, were reviewed. Demographic, clinical, and diagnostic data were collected. Eighty-two consecutive patients with a mean age of 52 years (range 22–72 years) who received either a PMMA (43/82; 52.4%) or CaP (39/82; 47.6%) cranial implant after DC were included in the study. Indications for DC were equally distributed in both groups. Time from DC to cranioplasty was 143.8 ± 17.5 days (PMMA) versus 98.5 ± 10.4 days (CaP). The mean follow-up period was 34.9 ± 27.1 months. Postoperative complications occurred in 13 patients with PMMA and 6 in those with CaP implants (13/43 [30.2%] vs. 6/39 [15.4%]; p = 0.115). Revision surgery with implant removal was necessary for 9 PMMA patients and in 1 with a CaP implant (9/43 [20.9%] vs. 1/39 [2.6%]; p = 0.0336); 6 PMMA implants were removed due to surgical site infection (SSI) (PMMA 6/43 [14%] vs. CaP 0/39 [0%]; p = 0.012). In this study, a biocompatible CaP implant seems to be superior to a PMMA implant in terms of SSI and postoperative complications. The absence of SSI supports the idea of the biocompatible implant material with its ability for osseointegration.
Role of Rotated Head Postures on Volunteer Kinematics and Muscle Activity in Braking Scenarios Performed on a Driving Simulator
Authors: Kempter Fabian , Lantella Lorena , Stutzig Norman , Fehr Jörg , Siebert Tobias 
Published: October 2022

AbstractOccupants exposed to low or moderate crash events can already suffer from whiplash-associated disorders leading to severe and long-lasting symptoms. However, the underlying injury mechanisms and the role of muscle activity are not fully clear. Potential increases in injury risk of non-nominal postures, i.e., rotated head, cannot be evaluated in detail due to the lack of experimental data. Examining changes in neck muscle activity to hold and stabilize the head in a rotated position during pre-crash scenarios might provide a deeper understanding of muscle reflex contributions and injury mechanisms. In this study, the influence of two different head postures (nominal vs. rotation of the head by about 63 ± 9° to the right) on neck muscle activity and head kinematics was investigated in simulated braking experiments inside a driving simulator. The braking scenario was implemented by visualization of the virtual scene using head-mounted displays and a combined translational-rotational platform motion. Kinematics of seventeen healthy subjects was tracked using 3D motion capturing. Surface electromyography were used to quantify muscle activity of left and right sternocleidomastoideus (SCM) and trapezius (TRP) muscles. The results show clear evidence that rotated head postures affect the static as well as the dynamic behavior of muscle activity during the virtual braking event. With head turned to the right, the contralateral left muscles yielded higher base activation and delayed muscle onset times. In contrast, right muscles had much lower activations and showed no relevant changes in muscle activation between nominal and rotated head position. The observed delayed muscle onset times and increased asymmetrical muscle activation patterns in the rotated head position are assumed to affect injury mechanisms. This could explain the prevalence of rotated head postures during a crash reported by patients suffering from WAD. The results can be used for validating the active behavior of human body models in braking simulations with nominal and rotated head postures, and to gain a deeper understanding of neck injury mechanisms.
“I miss my school!”: Examining primary and secondary school students’ social distancing and emotional experiences during the Covid-19 pandemic
Authors: Letzel-Alt Verena , Pozas Marcela , Schneider Christoph 
Published: October 2022

AbstractWith the rapid spread of Covid-19, countries around the world implemented strict protocols ordering schools to close. As a result, educational institutions were forced to establish a new form of schooling by implementing emergency remote education. Learning from home during the Covid-19 pandemic brought numerous changes, challenges, and stressors to students’ daily lives. In this context, major concerns have been raised based on the reports of students’ negative experiences resulting from social distancing and isolation. Given the impact of Covid-19 on many aspects of students’ lives, in particular their social and school experiences, research that provides insights into the consequences of this health crisis for students’ well-being has become important. This study aims to explore students’ experiences of social distancing and its relation to their negative emotional experiences during Germany’s first Covid-19–related school closure. Findings indicate that both primary and secondary students missed their friends and classmates and that primary school students perceived higher levels of social distancing. However, a linear regression analysis indicated that the older the students were, the more negatively affected they were by social distancing. The implications of the study’s results and further lines of research are discussed.
Does conduction heterogeneity determine the supervulnerable period after atrial fibrillation?
Authors: Heida Annejet , van der Does Willemijn F. B. , van Schie Mathijs S. , van Staveren Lianne N. , Taverne Yannick J. H. J. , Bogers Ad J. J. C. , de Groot Natasja M. S. 
Published: October 2022

Abstract

Atrial fibrillation (AF) resumes within 90 s in 27% of patients after sinus rhythm (SR) restoration. The aim of this study is to compare conduction heterogeneity during the supervulnerable period immediately after electrical cardioversion (ECV) with long-term SR in patients with AF. Epicardial mapping of both atria was performed during SR and premature atrial extrasystoles in patients in the ECV (N = 17, age: 73 ± 7 years) and control group (N = 17, age: 71 ± 6 years). Inter-electrode conduction times were used to identify areas of conduction delay (CD) (conduction times 7–11 ms) and conduction block (CB) (conduction times ≥ 12 ms). For all atrial regions, prevalences and length of longest CB and continuous CDCB lines, magnitude of conduction disorders, conduction velocity, biatrial activation time, and voltages did not differ between the ECV and control group during both SR and premature atrial extrasystoles (p ≥ 0.05). Hence, our data suggest that there may be no difference in biatrial conduction characteristics between the supervulnerable period after ECV and long-term SR in AF patients.
Graphical abstract
The supervulnerable period after AF termination is not determined by conduction heterogeneity during SR and PACs. It is unknown to what extent intra-atrial conduction is impaired during the supervulnerable period immediately after ECV and whether different right and left atrial regions are equally affected. This high-resolution epicardial mapping study (upper left panel) of both atria shows that during SR the prevalences and length of longest CB and cCDCB lines (upper middle panel), magnitude of conduction disorders, CV and TAT (lower left panel), and voltages did not differ between the ECV and control group. Likewise, these parameters were comparable during PACs between the ECV and control group (lower left panel). †Non-normally distributed. cm/s = centimeters per second; mm = millimeter; ms = millisecond; AF = atrial fibrillation; AT = activation time; BB = Bachmann’s bundle; cCDCB = continuous lines of conduction delay and block; CB = conduction block; CD = conduction delay; CT = conduction time; CV = conduction velocity; ECV = electrical cardioversion; LA = left atrium; LAT = local activation times; PAC = premature atrial complexes; PVA = pulmonary vein area; RA = right atrium; SR = sinus rhythm; TAT = total activation time.
Foundation ownership and firm growth
Authors: Block Joern , Fathollahi Reza 
Published: October 2022

AbstractPrior research has analyzed how different ownership types affect firm growth. Yet, so far, we know little about the effect of foundation ownership on firm growth. This is an important research gap as some of the largest firms in Western and Northern Europe are either fully or partly owned by foundations. Our study addresses this gap and analyzes the effects of foundation ownership on sales and employee growth. Based on a matched sample of foundation- and non-foundation-owned firms from the DACH (Germany, Austria, Switzerland) region, our analyses show that foundation-owned firms grow significantly less than non-foundation-owned firms in terms of sales but not with regard to employees. In addition, we find that the negative effect is stronger for the upper than for the middle or lower quantiles of the growth distribution. Our results can be explained through the characteristics of foundations as owners, particularly their long-term orientation and their goal of preserving the assets of the foundation. It seems that foundations as firm owners avoid the risks associated with extreme sales growth and aim for a risk-averse and conservative growth strategy.
Residential indoor exposure to fine and ultrafine particulate air pollution in association with blood pressure and subclinical central haemodynamic markers of cardiovascular risk among healthy adults living in Perth, Western Australia
Authors: Gilbey Suzanne E. , Reid Christopher M. , Zhao Yun , Soares Mario J. , Huxley Rachel R. , Rumchev Krassi B. 
Published: October 2022

Abstract
Despite that large percentages of individual daily time is spent in the home, few studies have examined the relationship between indoor particulate matter (PM) exposure in residential settings with subclinical indicators of cardiovascular risk. This cross-sectional study investigated associations between exposure to fine (PM2.5) and ultrafine (UFP) PM in domestic indoor environments, with central blood pressure (BP) and component BP measures (pulse pressure, augmented pressure [AP], augmentation index [AIx], mean arterial pressure, pulse wave velocity [PWV]) in 40 non-smoking, otherwise healthy adults (58% women) living in Perth, Western Australia. Overall, in adjusted models, an interquartile range (IQR) increase in PM2.5 was associated with a 3.2 mmHg (95% confidence interval [CI]: 0.99, 5.45) higher diastolic BP, and a 1.8 mmHg lower AP (95%CI: − 3.63, − 0.01) and 0.4 m/s PWV (95%CI: − 0.80, − 0.08), respectively. For the UFP fraction, an IQR increase was associated with a 5.2% higher AIx (95%CI: 0.51, 9.97) and a 0.6 m/s lower PWV (95%CI: − 1.00, − 0.11).When stratified by sex, higher UFP concentrations were associated with higher DBP and lower PWV among women. Among men, higher UFP concentrations were associated with lower AP. Exposure to domestic indoor fine and ultrafine PM was associated with preclinical indicators of cardiovascular risk and some of these relationships were affected by sex. These findings contribute important evidence linking low-level residential indoor PM exposure with measurable impacts on cardiovascular physiology and may inform preventative recommendations as part of risk profiles for susceptible individuals.
A dynamic analysis of industrial energy efficiency and the rebound effect: implications for carbon emissions and sustainability
Authors: Amjadi Golnaz , Lundgren Tommy , Zhou Wenchao 
Published: October 2022

AbstractEnergy efficiency improvement (EEI) is generally known to be a cost-effective measure for meeting energy, climate, and sustainable growth targets. Unfortunately, behavioral responses to such improvements (calledenergy rebound effects) may reduce the expected savings in energy and emissions from EEI. Hence, the size of this effect should be considered to help design efficient energy and climate targets. Currently, there are significant differences in approaches for measuring the rebound effect. Here, we used a two-step procedure to measure both short- and long-term energy rebound effects in the Swedish manufacturing industry. In the first step, we used data envelopment analysis (DEA) to measure energy efficiency. In the second step, we use the efficiency scores and estimated a derived energy demand equation including rebound effects using a dynamic panel regression model. This approach was applied to a firm-level panel dataset covering 14 sectors in Swedish manufacturing over the period 1997–2008. We showed that, in the short run, partial and statistically significant rebound effects exist within all manufacturing sectors, meaning that the rebound effect decreased the energy and emission savings expected from EEI. The long-term rebound effect was in general smaller than the short-term effect, implying that within each sector, energy and emission savings due to EEI are larger in the long run compared to the short run. Using our estimates of energy efficiency and rebound effect, we further performed a post-estimation analysis to provide a guide to policy makers by identifying sectors where EEI have the most potential to promote sustainable economic growth with the lowest environmental impact.
Screening, diagnosis and follow-up of Brugada syndrome in children: a Dutch expert consensus statement
Authors: Peltenburg P. J. , Hoedemaekers Y. M. , Clur S. A. B. , Blom N. A. , Blank A. C. , Boesaard E. P. , Frerich S. , van den Heuvel F. , Wilde A. A. M. , Kammeraad J. A. E. 
Published: October 2022

AbstractBrugada syndrome (BrS) is a rare inherited arrhythmia syndrome. Affected children may experience life-threatening symptoms, mainly during fever. The percentage of SCN5A variant carriers in children is higher than in adults. Current diagnostic and follow-up policies for children with (a family history of) BrS vary between centres. Here, we present a consensus statement based on the current literature and expert opinions to standardise the approach for all children with BrS and those from BrS families in the Netherlands. In summary, BrS is diagnosed in patients with a spontaneous type 1 electrocardiogram (ECG) pattern or with a Shanghai score ≥ 3.5 including ≥ 1 ECG finding. A sodium channel-blocking drug challenge test should only be performed after puberty with a few exceptions. A fever ECG is indicated in children with suspected BrS, in children with a first-degree family member with definite or possible BrS according to the Shanghai criteria with a SCN5A variant and in paediatric SCN5A variant carriers. In-hospital rhythm monitoring during fever is indicated in patients with an existing type 1 ECG pattern and in those who develop such a pattern. Genetic testing should be restricted to SCN5A. Children with BrS and children who carry an SCN5A variant should avoid medication listed at www.brugadadrugs.org and fever should be suppressed. Ventricular arrhythmias or electrical storms should be treated with isoproterenol infusion.
Quality early childhood education through self, workplace, or regulatory support: exploring the efficacy of professional registration for early childhood teachers in Australia
Authors: Fenech Marianne , Watt Helen 
Published: October 2022

AbstractTeacher registration is increasingly utilised as a governance mechanism to audit teachers’ work and drive professional practice. There is limited and mixed empirical evidence, however, as to whether registration drives teaching quality. Our study extends this limited empirical base by critically examining the policy trajectory in Australia to bring early childhood teachers into a uniform system of registration with primary and secondary teachers. Adopting a relatively novel methodology, the study intertwined a critical social policy framing with a national quantitative survey. Results showed that respondents perceived their professional self, followed by their workplace (colleagues and employer) as key influencers of quality practice, and neither agreed nor disagreed that teacher registration was beneficial. Findings problematise the need for, and benefits of, teacher registration. That early childhood teachers’ practice and development was most driven by intrinsic motivation and, to a lesser extent, being employed in high-quality, not-for-profit, and preschool settings where other early childhood teachers are employed, suggests that more effective and progressive policy approaches to support quality early childhood education require an addressing of the contexts and conditions in which early childhood teachers work.
Rational points on hyperelliptic Atkin-Lehner quotients of modular curves and their coverings
Authors: Adžaga Nikola , Chidambaram Shiva , Keller Timo , Padurariu Oana 
Published: October 2022

AbstractWe complete the computation of all$$\mathbb {Q}$$Q-rational points on all the 64 maximal Atkin-Lehner quotients$$X_0(N)^*$$X0(N)∗such that the quotient is hyperelliptic. To achieve this, we use a combination of various methods, namely the classical Chabauty–Coleman, elliptic curve Chabauty, quadratic Chabauty, and the bielliptic quadratic Chabauty method (from a forthcoming preprint of the fourth-named author) combined with the Mordell-Weil sieve. Additionally, for square-free levelsN, we classify all$$\mathbb {Q}$$Q-rational points as cusps, CM points (including their CM field andj-invariants) and exceptional ones. We further indicate how to use this to compute the$$\mathbb {Q}$$Q-rational points on all of their modular coverings.
An Adaptive Elastic Multi-model Big Data Analysis and Information Extraction System
Authors: Yin Qiang , Wang Jianhua , Du Sheng , Leng Jianquan , Li Jintao , Hong Yinhao , Zhang Feng , Chai Yunpeng , Zhang Xiao , Zhao Xiaonan , Li Mengyu , Xiao Song , Lu Wei 
Published: October 2022

AbstractWith the diverse applications to industry and domain-specific context, multi-source information extraction on semi-structured and unstructured data, as well as across data models, is becoming more common. However, multi-model information extraction often requires the deployment of multiple data model management, storage, and analysis subsystems on the cloud, many subsystems are not high-resource utilization at the same time, and the resource waste phenomenon is often serious. Therefore, an adaptive scalable multi-model big data analysis and information extraction system is designed and implemented in this paper, which can support data maintenance and cross-model query of relational, graph, document, key and other data models, and can provide efficient cross-model information extraction. On this basis, we can achieve the system resource allocation on demand and fast scaling mechanism, according to the real-time requirements of multi-model big data analysis, and dynamic adjustment of each subsystem resource allocation. Therefore, our solution not only guarantees multi-model query and information extraction performance and quality of service, but also significantly reduces the total consumption of system resources and cost.