bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards Multilayered Coatings of 304L Stainless Steels Using Friction Surfacing
Authors: Agiwal Hemant , Baumann Christian , Krall Stephan , Yeom Hwasung , Sridharan Kumar , Bleicher Friedrich , Pfefferkorn Frank E. 
Published: July 2022

Abstract
The objective of this work is to study friction surfacing process variability when depositing multilayered coatings. This is motivated by the need to maintain deposition quality when depositing multiple friction surfacing layers, whether for repair, remanufacturing, or new part creation using this solid-state metal additive manufacturing process. In this study, 10-mm-diameter 304L stainless steel rods were used to create up to five layers of 40-mm-long coatings on 304L substrates using a constant set of processing parameters. In-process measurement of forces (X, Y, Z), flash temperature, flash geometry, layer temperature, and post-process measurement of layer geometry, microhardness, and microstructure are used to characterize changes in the friction surfacing process as more layers are deposited. It was observed that with increasing layers: layer thickness and deposition efficiency decrease; offsetting of the deposition towards the retreating side, and temperature in the deposited layer increase; and flash temperature does not change. Metallurgical analyses of friction-surfaced cross-sections revealed fine grain refinement and transformation of base austenite to strain-induced martensite. It is concluded that the process parameters need to be adjusted even after the second or third layer is deposited, corrections to the tool path are required after a couple of layers, and the measured process forces, as well as deposited layer temperature, may be useful to monitor and control the process and its instabilities.
Biophysical Impact of 5-Week Training Cessation on Sprint Swimming Performance
Authors: Ruiz-Navarro Jesús J. , Gay Ana , Zacca Rodrigo , Cuenca-Fernández Francisco , López-Belmonte Óscar , López-Contreras Gracia , Morales-Ortiz Esther , Arellano Raúl 
Published: July 2022

Purpose: To assess changes in swimming performance, anthropometrics, kinematics, energetics, and strength after 5-week training cessation. Methods: Twenty-one trained and highly trained swimmers (13 males: 17.4 [3.1] y; 50-m front crawl 463 [77] FINA points; 8 females: 16.7 [1.7] y; 50-m front crawl 535 [48] FINA points) performed a 50-m front-crawl all-out swim test, dryland and pool-based strength tests, and 10-, 15-, 20-, and 25-m front-crawl all-out efforts for anaerobic critical velocity assessment before and after a 5-week training cessation. Heart rate and oxygen uptake () were continuously measured before and after the 50-m swim test (off-kinetics). Results: Performance was impaired 1.9% (0.54 s) for males (P = .007, d = 0.91) and 2.9% (0.89 s) for females (P = .033, d = 0.93). Neither the anthropometrical changes (males: r2 = .516, P = .077; females: r2 = .096, P = .930) nor the physical activities that each participant performed during the off-season (males: r2 = .060, P = .900; females: r2 = .250, P = .734) attenuated performance impairments. Stroke rate and clean swimming speed decreased (P < .05), despite similar stroke length and stroke index (P > .05). Blood lactate concentrations remained similar (P > .05), but peak decreased in females (P = .04, d = 0.85). Both sexes showed higher heart rate before and after the 50-m swim test after 5 weeks (P < .05). Anaerobic metabolic power deterioration was only observed in males (P = .035, d = 0.65). Lower in-water force during tethered swimming at zero speed was observed in males (P = .033, d = 0.69). Regarding dryland strength, lower-body impairments were observed for males, while females showed upper-body impairments (P < .05). Conclusions: A 5-week training cessation yielded higher heart rate in the 50-m front crawl, anaerobic pathways, and dryland strength impairments. Coaches should find alternatives to minimize detraining effects during the off-season.
Correlates of Sedentary Time Among Children and Adolescents in Ethiopia: A Cross-Sectional Study
Authors: Biadgilign Sibhatu , Mgutshini Tennyson , Gebremichael Bereket , Haile Demewoz , Berhanu Lioul , Chitekwe Stanley , Memiah Peter 
Published: July 2022

Purpose: To assess the correlates of sedentary time among children and adolescents in Ethiopia. Methods: The study was conducted in representative samples of children and adolescents in the capital city of Ethiopia, Addis Ababa. Multivariable logistic regression models were used to determine associations of sedentary time and predictor variables. Results: The mean sedentary time was 4.61 (95% confidence interval [CI], 4.35–4.86) hours per day. Overall, the prevalence of high sedentary time (>3 h/d) was 68.2% (95% CI, 64.2–72.2). Results of multivariable logistic regression analyses showed a statistically significant association between high sedentary time and female household head (adjusted odds ratio [AOR] = 0.50; 95% CI, 0.32–0.80), literate mothers (AOR = 1.98; 95% CI, 1.26–3.11), child attending public school (AOR = 1.79; 95% CI, 1.12–2.85), children who belonged to the poor and rich household wealth tertiles compared with medium wealth tertile (AOR = 2.30; 95% CI, 1.42–3.72 and AOR = 2.04; 95% CI, 1.14–3.65, respectively), and those families that did not have adequate indoor play space for children (AOR = 0.45; 95% CI, 0.29–0.72). Conclusion: The study found that time spent sedentary was high in the study area as compared with other studies of similar settings. Several modifiable factors were identified that can be targeted in interventions to reduce sedentary time in the study setting.
Community seroprevalence of SARS-CoV-2 in children and adolescents in England, 2019–2021
Authors: Ratcliffe Helen , Tiley K S , Andrews Nick , Amirthalingam Gayatri , Vichos I , Morey E , Douglas N L , Marinou S , Plested Emma , Aley Parvinder , Galiza Eva P , Faust Saul N , Hughes S , Murray Clare S , Roderick Marion , Shackley Fiona , Oddie Sam J , Lees Tim , Turner D P J , Raman M , Owens Stephen , Turner Paul , Cockerill H , Lopez Bernal J , Linley E , Borrow Ray , Brown Kevin , Ramsay Mary Elizabeth , Voysey M , Snape Matthew D 
Published: July 2022

ObjectiveTo understand community seroprevalence of SARS-CoV-2 in children and adolescents. This is vital to understanding the susceptibility of this cohort to COVID-19 and to inform public health policy for disease control such as immunisation.DesignWe conducted a community-based cross-sectional seroprevalence study in participants aged 0–18 years old recruiting from seven regions in England between October 2019 and June 2021 and collecting extensive demographic and symptom data. Serum samples were tested for antibodies against SARS-CoV-2 spike and nucleocapsid proteins using Roche assays processed at UK Health Security Agency laboratories. Prevalence estimates were calculated for six time periods and were standardised by age group, ethnicity and National Health Service region.ResultsPost-first wave (June–August 2020), the (anti-spike IgG) adjusted seroprevalence was 5.2%, varying from 0.9% (participants 10–14 years old) to 9.5% (participants 5–9 years old). By April–June 2021, this had increased to 19.9%, varying from 13.9% (participants 0–4 years old) to 32.7% (participants 15–18 years old). Minority ethnic groups had higher risk of SARS-CoV-2 seropositivity than white participants (OR 1.4, 95% CI 1.0 to 2.0), after adjusting for sex, age, region, time period, deprivation and urban/rural geography. In children <10 years, there were no symptoms or symptom clusters that reliably predicted seropositivity. Overall, 48% of seropositive participants with complete questionnaire data recalled no symptoms between February 2020 and their study visit.ConclusionsApproximately one-third of participants aged 15–18 years old had evidence of antibodies against SARS-CoV-2 prior to the introduction of widespread vaccination. These data demonstrate that ethnic background is independently associated with risk of SARS-CoV-2 infection in children.Trial registration numberNCT04061382.
Cardiovascular risk management in people with type 1 diabetes: performance using three guidelines
Authors: Varkevisser Rita Delphine Maiko , Birnie Erwin , Vollenbrock Charlotte E , Mul Dick , van Dijk Peter R , van der Klauw Melanie M , Veeze Henk , Wolffenbuttel Bruce H R , Aanstoot Henk-Jan 
Published: July 2022

IntroductionCardiovascular disease (CVD) is the leading cause of mortality in individuals with type 1 diabetes mellitus (T1DM). Cardiovascular risk management is therefore essential in the management of individuals with T1DM. This study describes the performance of lipid and blood pressure management in individuals with T1DM using three guidelines.Research design and methodsIndividuals ≥18 years with T1DM, treated with insulin for ≥1 year, visiting Diabeter or the University Medical Center Groningen between January 1, 2018 and December 31, 2018, were included. Lipid and blood pressure management were examined using the Dutch, American Diabetes Association (ADA) and National Institute for Health and Care Excellence (NICE) guidelines. Concordance of recommended and prescribed lipid-lowering (LLM) or antihypertensive medication (AHM) was assessed per guideline and 10-year age groups. Achievement of treatment targets was assessed for those prescribed medication.ResultsA total of 1855 individuals with T1DM were included. LLM and AHM was prescribed in 19% and 17%, respectively. In individuals recommended LLM, this was prescribed in 22%–46% according to Dutch, ADA or NICE guideline recommendations. For individuals recommended AHM, this was prescribed in 52%–75%. Recommended and actual prescription of LLM and AHM increased over age for all three guidelines. However, discordance between treatment recommendation and medication prescribed was higher in younger, compared with older, age groups. Low-density lipoprotein-cholesterol targets were achieved by 50% (without CVD) and 31% (with CVD) of those prescribed LLM. The blood pressure target was achieved by 46% of those prescribed AHM.ConclusionThis study suggests that there is undertreatment of lipid and blood pressure according to guideline recommendations, particularly in younger age groups. Treatment targets are not met by most individuals prescribed medication, while guidelines recommendations differ considerably. We recommend to investigate the factors influencing undertreatment of lipid and blood pressure management in individuals with T1DM.
Aboriginal peoples’ perspectives about COVID-19 vaccines and motivations to seek vaccination: a qualitative study
Authors: Graham Simon , Blaxland Megan , Bolt Reuben , Beadman Mitchell , Gardner Kristy , Martin Kacey , Doyle Michael , Beetson Karen , Murphy Dean , Bell Stephen , Newman Christy E , Bryant Joanne 
Published: July 2022

IntroductionAboriginal and Torres Strait Islander (Aboriginal) people compared with non-Aboriginal people in Australia have higher rates of chronic conditions. These conditions increase the risk of poorer health outcomes if infected with COVID-19, highlighting the importance of COVID-19 vaccination. This study examined what Aboriginal people think about COVID-19 vaccines, reasons why they were vaccinated or not vaccinated and factors involved in receiving COVID-19 vaccination.MethodsWe used a participatory peer researcher method to interview 35 Aboriginal people aged 15–80 years living in Western Sydney, Australia. Local Aboriginal people who had ties with the community conducted the interviews. The questions and analyses were framed using the WHO’s Behavioural and Social Drivers of COVID-19 model. Interviews occurred between February 2021 and March 2021. Peer researchers were paid for their time in training and to conduct the interviews and each participant received $50.ResultsReasons why participants would seek vaccination included: to protect themselves from infection and severe illness, to protect others in their community, to travel again and to return to ‘normal life’. Reasons why some participants were hesitant about being vaccinated included: fear of vaccine side effects; negative stories on social media; and distrust in Australian governments and medical institutions. Aboriginal people preferred to access COVID-19 vaccination through their local Aboriginal Health Service or a general practitioner they already knew.ConclusionAchieving high vaccination rates in Aboriginal communities is possible if vaccination programmes are delivered through trusted general practitioners or Aboriginal Health Services.
An analysis of tax abuse, debt, and climate change risk in low-income and lower-middle-income countries
Authors: Lopez Marisol J , O'Hare Bernadette Anne-Marie , Hannah Eilish , Hall Stephen 
Published: July 2022

IntroductionClimate change is exacerbating a pre-existing child rights crisis. Lower- (low- and lower-middle-) income countries have borne 99% of the disease burden from the crisis, of which children under five carry 90%. In response, much of the recent global policy efforts focus on climate action. However, unsustainable levels of debt and tax abuses are draining countries of crucial revenue to handle the crisis. Like the climate crisis, these are primarily facilitated by entities domiciled within higher- (upper-middle- and high-) income countries. This paper aims to review these revenue leaks in countries where children are at the greatest risk of climate change to identify opportunities to increase climate change resilience.MethodsWe compiled data on tax abuse, debt service and climate risk for all lower-income countries with available data to highlight the need for intervention at the global level. We used the Climate Change Risk Index (CCRI), developed by UNICEF. Additionally, we used figures for tax abuse and debt service as a percentage of government revenue.ResultsWe present data on 62 lower-income countries with data on revenue losses, of which 55 have CCRI data. Forty-two of these 62 countries (67.7%) are at high risk of lost government revenues. Forty-one (74.5%) of the 55 countries with CCRI data are at high risk of climate change. Thirty-one countries with data on both (56.4%) are at high risk of both climate change and revenue losses. Most countries at high risk of both are located in sub-Saharan Africa. This shows that countries most in need of resources lose money to arguably preventable leaks in government revenue.DiscussionHigher-income countries and global actors can adopt policies and practices to ensure that they do not contribute to human rights abuses in other countries. Highlighting the impact of a failing global economic model on children’s economic and social rights and one which increases their vulnerability to the climate emergency could help drive the transition towards a model that prioritises human rights and the environment on which we all depend.
Smoking and socioeconomic factors linked to acute exacerbations of COPD: analysis from an Asthma + Lung UK survey
Authors: Williams Parris J , Cumella Andrew , Philip Keir Elmslie James , Laverty Anthony A , Hopkinson Nicholas S 
Published: July 2022

BackgroundUnderstanding the factors driving acute exacerbations of chronic obstructive pulmonary disease (COPD) is key to reducing their impact on human health and well-being.Methods5997 people with COPD, mean 66 years, 64% female, completed an online survey between December 2020 and May 2021 about living with COPD, developed by the charity Asthma + Lung UK.ResultsThe 3731 (62.2%) survey participants reporting frequent (≥2/year) exacerbations were more likely to smoke (adjusted OR (AOR) 1.70, 95% CI 1.470 to 1.98), have lower annual household income (≤£20 000 (AOR 1.72, 95% CI 1.36 to 2.17), live in a cold and damp home (AOR 1.78, 95% CI 1.50 to 2.11) and report previous occupational exposure to dust, fumes and chemicals. Smokers were more likely to report attending hospital to manage their most recent acute exacerbation of COPD compared with ex-smokers (AOR 1.25, 95% CI 0.99 to 1.59).DiscussionStrategies to improve COPD outcomes must address issues of deprivation and social justice.
Automatic CD30 scoring method for whole slide images of primary cutaneous CD30+lymphoproliferative diseases
Authors: Zheng Tingting , Zheng Song , Wang Ke , Quan Hao , Bai Qun , Li Shuqin , Qi Ruiqun , Zhao Yue , Cui Xiaoyu , Gao Xinghua 
Published: July 2022

AimsDeep-learning methods for scoring biomarkers are an active research topic. However, the superior performance of many studies relies on large datasets collected from clinical samples. In addition, there are fewer studies on immunohistochemical marker assessment for dermatological diseases. Accordingly, we developed a method for scoring CD30 based on convolutional neural networks for a few primary cutaneous CD30+lymphoproliferative disorders and used this method to evaluate other biomarkers.MethodsA multipatch spatial attention mechanism and conditional random field algorithm were used to fully fuse tumour tissue characteristics on immunohistochemical slides and alleviate the few sample feature deficits. We trained and tested 28 CD30+immunohistochemical whole slide images (WSIs), evaluated them with a performance index, and compared them with the diagnoses of senior dermatologists. Finally, the model’s performance was further demonstrated on the publicly available Yale HER2 cohort.ResultsCompared with the diagnoses by senior dermatologists, this method can better locate the tumour area and reduce the misdiagnosis rate. The prediction of CD3 and Ki-67 validated the model’s ability to identify other biomarkers.ConclusionsIn this study, using a few immunohistochemical WSIs, our model can accurately identify CD30, CD3 and Ki-67 markers. In addition, the model could be applied to additional tumour identification tasks to aid pathologists in diagnosis and benefit clinical evaluation.
Influence of menstrual cycle on muscle glycogen utilization during high-intensity intermittent exercise until exhaustion in healthy women
Authors: Matsuda Tomoka , Takahashi Hideyuki , Nakamura Mariko , Kanno Moe , Ogata Hazuki , Ishikawa Akira , Yamada Mizuki , Kamemoto Kayoko , Sakamaki-Sunaga Mikako 
Published: July 2022

The present study investigated the effects of the menstrual cycle on muscle glycogen and circulating substrates during high-intensity intermittent exercise until exhaustion in healthy women who habitually exercised. In total, 11 women with regular menstrual cycles completed three tests, which comprised the early follicular phase (E-FP), late follicular phase (L-FP), and luteal phase (LP) of the menstrual cycle. High-intensity intermittent exercise until exhaustion was performed on each test day. Evaluation of muscle glycogen concentration by 13C-magnetic resonance spectroscopy and measurement of estradiol, progesterone, blood glucose, lactate, free fatty acids (FFA), and insulin concentrations were conducted before exercise (Pre) and immediately after exercise (Post). Muscle glycogen concentrations from thigh muscles at Pre and Post were not significantly different between menstrual cycle phases ( P = 0.57). Muscle glycogen decreases by exercise were significantly greater in L-FP (59.0 ± 12.4 mM) than in E-FP (48.3 ± 14.4 mM, P < 0.05). Nonetheless, blood glucose, blood lactate, serum FFA, serum insulin concentrations, and exercise time until exhaustion in E-FP, L-FP, and LP were similar. The study results suggest that although exercise time does not change according to the menstrual cycle, the menstrual cycle influences muscle glycogen utilization during high-intensity intermittent exercise until exhaustion in women with habitual exercise activity. Novelty: This study compared changes in muscle glycogen concentration across the menstrual cycle during high-intensity intermittent exercise until exhaustion using 13C-magnetic resonance spectroscopy. Our results highlight the influence of the menstrual cycle on muscle glycogen during high-intensity intermittent exercise in healthy women.
System of excitons bound at oxygen centers and stimulated emission of CdS crystals
Authors: Morozova N. K. , Abbasov I. I. 
Published: July 2022

The paper presents the results of a study of the optical properties of CdS on the basis of the band anticrossing theory (BAC) with the involvement of the wider source data to the analysis results. Depending on the growth conditions, the presence and change in the concentration of oxygen and intrinsic point defects, which determine the composition of the crystals, have been taken into account. Data from studies of the structural features of crystals have also been used. The concept of nonuniform distribution of oxygen isoelectronic centers in the CdS volume due to their predominant segregation in layers of stacking faults (SFs) and also on dislocations has been introduced. To analyze the optical data, the capabilities of the method for constructing band models, which collect extensive and multilateral information about specific samples have been used. A refined model multizone of [Formula: see text] with SFs, which determines the spectrum of edge emission, has been presented. The nature of the edge emission A2B6 crystals with a small deviation from stoichiometry (CdS type) was explained as a spectrum of bound excitons at oxygen centers in SF layers. The article gives recommendations for the diagnostics of CdS crystals, suitable for creating stable luminescent systems or lasers.
Activating mTOR Mutations Are Detrimental in Nutrient-Poor Conditions
Authors: Bielska Agata A. , Harrigan Caitlin F. , Kyung Yeon Ju , Morris Quaid , Palm Wilhelm , Thompson Craig B. 
Published: July 2022

Abstract

The mTOR is a key regulator of cell growth that integrates growth factor signaling and nutrient availability and is a downstream effector of oncogenic receptor tyrosine kinases (RTK) and PI3K/Akt signaling. Thus, activating mTOR mutations would be expected to enhance growth in many tumor types. However, tumor sequencing data have shown that mTOR mutations are enriched only in renal clear cell carcinoma, a clinically hypervascular tumor unlikely to be constrained by nutrient availability. To further define this cancer-type–specific restriction, we studied activating mutations in mTOR. All mTOR mutants tested enhanced growth in a cell-type agnostic manner under nutrient-replete conditions but were detrimental to cell survival in nutrient-poor conditions. Consistently, analysis of tumor data demonstrated that oncogenic mutations in the nutrient-sensing arm of the mTOR pathway display a similar phenotype and were exceedingly rare in human cancers of all types. Together, these data suggest that maintaining the ability to turn off mTOR signaling in response to changing nutrient availability is retained in most naturally occurring tumors.

Significance:
This study suggests that cells need to inactivate mTOR to survive nutrient stress, which could explain the rarity of mTOR mutations and the limited clinical activity of mTOR inhibitors in cancer.