bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of non-pharmacological interventions for the treatment of hypertension in primary care: a narrative review of effectiveness, cost-effectiveness, barriers, and facilitators
Authors: Dhungana Raja Ram , Pedisic Zeljko , de Courten Maximilian 
Published: November 2022

AbstractBackgroundThe current guidelines for the prevention, detection, evaluation, and management of hypertension recommend six types of non-pharmacological interventions: alcohol reduction, salt intake reduction, increased potassium intake, physical activity, weight loss, and heart-healthy diets. However, the non-pharmacological interventions are still not widely used in primary care. In this paper, we, therefore, reviewed and summarised the evidence on the effectiveness, cost-effectiveness, barriers, and facilitators of non-pharmacological interventions for the treatment of hypertension in primary care.MethodsA thorough literature search was conducted in Embase, Google Scholar, and PubMed databases, to identify the most recent reviews or, in their absence, primary studies on alcohol reduction, salt intake reduction, potassium supplementation, physical activity, weight reduction, heart-healthy diets, and other non-pharmacological interventions for the treatment of hypertension in primary care.ResultsAlcohol reduction is a non-pharmacological intervention for the treatment of hypertension in primary care with proven effectiveness, feasibility, and acceptability. Interventions for sodium intake reduction, physical activity, and weight reduction are effective but there is insufficient evidence regarding their feasibility and acceptability in primary care settings. Evidence on the effectiveness of potassium intake and heart-healthy diets is limited and inconsistent. There is a lack of evidence on the cost-effectiveness of non-pharmacological interventions in the treatment of hypertension. The most common barriers to deliver such interventions related to healthcare providers include a lack of time, knowledge, self-confidence, resources, clear guidelines, and financial incentives. The most common barriers related to patients include a lack of motivation and educational resources. Less evidence is available on facilitators of implementing non-pharmacological interventions in primary care. Besides, facilitators differed by different types of interventions.ConclusionsAvailable evidence suggests that more pragmatic, clinically feasible, and logistically simple interventions are required for sodium intake reduction, physical activity, and weight reduction in primary care settings. Future studies should provide further evidence on the effectiveness of weight control, potassium intake, and heart-healthy diets. More research is also needed on cost-effectiveness and facilitators of all types of effective non-pharmacological interventions for the treatment of hypertension in primary care.
Bladder nephrogenic adenoma as a complication of surgical correction of megaureter
Authors: Rostyslav Nakonechnyy , Andrii Nakonechnyi 
Published: November 2022

Abstract
Background
Bladder nephrogenic adenoma (BNA) is a rare benign proliferative pathology of its mucosa. The etiopathogenesis of the disease remains uncertain, and the treatment is still challenging.

Case presentation
In this article, we present a clinical case of bladder nephrogenic adenoma in a 6-year-old boy. Clinical symptoms of the disease appeared 3 years after surgical treatment of obstructive megaureter. Histopathological and immunohistochemical examination of glandular polyp biopsies allowed excluding the tumor process and making a diagnosis.

Conclusion
Nephrogenic adenomas demonstrate a variety of morphologic patterns that may occasionally be confused with malignant processes. We described the endoscopic characteristics of BNA and characterized its histological and immunohistochemical features in a boy after ureteroneocystostomy.
A sensitive, heart-cutting, two-dimensional liquid chromatography–tandem mass spectrometry method for the determination of mometasone furoate in human plasma: Application for a bioequivalence study in nasal spray formulations
Authors: Yang Leting , Yang Hongyi , Xie Huiru , Liu Hui , He Gangmin , Zhong Wenjing , Wang Ling 
Published: November 2022

AbstractWe developed and validated a sensitive, heart-cutting, two-dimensional liquid chromatography–tandem mass spectrometry (2D-LC‒MS/MS) method to determine the concentration of mometasone furoate in human plasma after nasal spray administration. Isotopically labeled mometasone furoate-13C,d6 was used as an internal standard (IS). Plasma samples were prepared using a solid-phase extraction (SPE) method. With this 2D-LC strategy, the analytes were trapped in the first dimension (1D) column, and only judiciously selected portions of the 1D effluent were transferred to the second dimension (2D) column for further separation to obtain high-resolution information. MS/MS quantification was performed in positive ionization mode via multiple-reaction monitoring (MRM). This analytical method was fully validated according to related regulatory guidance, and the results showed that the method is robust and sensitive enough for pharmacokinetic investigation of mometasone furoate with satisfactory linearity from 0.25 to 30 pg mL−1. This method was successfully applied to a bioequivalence (BE) study of mometasone furoate aqueous nasal sprays in healthy volunteers.
Effectiveness of Adjuvant Chemotherapy for elderly Patients with Triple-Negative Breast Cancer
Authors: Guo Qiusheng , Lan Tian , Lu Yunyan , Hu Zujian , Xu Haibin , Wang Xiaojia , Shao Xiying , Fu Xueyan 
Published: November 2022

There is little evidence determining whether elderly patients (from 70 to 90 years old) with triple-negative breast cancer could benefit from adjuvant chemotherapy (AC). This study explores the effect of AC in these population following surgery. A total of 4610 patients were identified in the Surveillance, Epidemiology, and End Results database (2010-2018). Multiple imputation by chained equations was performed to impute missing data. Inverse probability of treatment weighting (IPTW) was applied to reduce the selection bias. IPTW-adjusted Kaplan-Meiers survival analysis and Cox proportional hazards models were performed to compare breast cancer specific survival (BCSS) and overall survival (OS) in the two treatment groups. The patients were classified into the chemotherapy (n=1989) and the observation (n=2621) groups. The percentage of patients receiving AC versus observation increased significantly from 2010 to 2018 (estimated annual percentage change, 1.49%; 95%CI, 0.75-2.16%, p=0.002). The 5-year IPTW-adjusted rates of BCSS and OS in AC group were better than that in observation group (BCSS: 82.32% vs. 78.42%, p=0.010; OS: 75.54% vs. 64.65%, p<0.001). The patients could benefit from AC based on the results of IPTW-adjusted Cox proportional hazards regression analysis (BCSS: HR, 0.77, 95%CI, 0.62-0.94, p=0.012; OS: HR, 0.66, 95%CI, 0.57-0.78, p<0.001). AC was associated with a significant outcome benefit across the year at diagnosis, marital status, stage, lymph node, surgery, and radiation subgroups (all p<0.050). Patients with T1ab could not benefit from AC (p>0.050). In conclusion, we presented a BCSS and OS benefit from AC in elderly patients with triple-negative breast cancer (TNBC). AC remained a reasonable treatment approach in these specific patients. For the patients with T1ab, de-escalated treatment would be administrated with caution.
DEPREDACIÓN DE GRISÓN GRANDE (Galictis vittata) POR ÁGUILA HARPÍA Harpia harpyja
Authors: Maldonado Casanova Gabriel Enrique , Ninabanda Ramiro , Licuy Mayra 
Published: November 2022

En esta nota de campo presentamos el registro de un individuo juvenil de Águila Harpía (Harpía harpyja) alimentándose de un Hurón (Galictis vittata) en la Amazonía ecuatoriana.
Opiniones sobre el desempeño docente y sus repercusiones en la satisfacción profesional y personal de los profesores
Authors: González Such José , Subaldo Suizo Lucía 
Published: November 2022

En este trabajo se presenta una revisión sobre el desempeño docente y su relación con la satisfacción/insatisfacción personal y laboral del profesorado que repercute en el profesor y que puede conducir a desgaste en su salud y bienestar. El objetivo de este trabajo se centra en el conocimiento de las opiniones y vivencias del profesorado sobre el desempeño y sus repercusiones en la satisfacción laboral y personal del profesorado e identificar los factores fundamentales de satisfacción/ insatisfacción de los docentes. Los resultados indican que las experiencias positivas del profesorado en el ejercicio de la docencia producen satisfacción y conllevan el desarrollo y la realización personal y profesional, que tienen gran influencia en la enseñanza y el aprendizaje del alumnado, mientras que las experiencias negativas producen insatisfacción personal y profesional.
Clinical effects of combined anteversion and offset on postoperative dislocation in total hip arthroplasty
Authors: Matsuda Kenta , Hidaka Ryo , Nakamura Shigeru , Nakamura Masaki , Kawano Hirotaka 
Published: November 2022

Abstract
Background
Implant impingement and soft tissue tension are factors involved in dislocation after total hip arthroplasty (THA). Combined anteversion (CA) has been used as an indicator for implant placement; however, placing implants optimally remains challenging. Moreover, the effect of changes in offset on dislocation remains unclear. We aimed to clarify the effects of postoperative CA and pre- and postoperative changes in offset on dislocation.
Methods
We included patients who underwent primary cementless THA performed between 2013 and 2020. The mean values of CA and offset in the dislocation and non-dislocation groups were compared. The CA values within ± 10% of the recommended values were defined as good CA, and those outside the range were defined as poor CA. The dislocation rates in the good and poor CA groups and in the groups with and without increased offset were compared.
Results
A total of 283 hips were included. The mean values of CA in the dislocation and non-dislocation groups were significantly different (p < 0.001). The dislocation rate was significantly lower in the good CA group (p < 0.05). The dislocation rates in the groups with and without increased total offset were 0.5% and 4.3%, respectively (p = 0.004). There were no dislocations in patients with good CA and increased offset.
Conclusions
The dislocation rate was significantly lower when implants were placed within ± 10% of the recommended CA value. Our results suggest that dislocation can be avoided by placing the implant in the good CA range and considering the increase in total offset on the operative side.
A Comparative study of Posterior cingulate metabolism in Patients with Mild Cognitive Impairment due to Parkinson’s Disease or to Alzheimer’s Disease
Authors: Huang Mingming , Cai Xi , Zhang Yong , Pu Wei , Gao Bo , Yu Hui 
Published: November 2022

AbstractFew comparative studies exist of metabolic brain changes in cognitive impairment among neurodegenerative illnesses. In this study, we compared posterior cingulate (PCC) metabolic abnormalities in patients with mild cognitive impairment (MCI) due to Parkinson’s disease (PD) and to Alzheimer’s disease (AD) as measured by proton magnetic resonance spectroscopy (1H-MRS). Thirty eight patients with idiopathic PD, including 20 patients with mild cognitive impairment (PDMCI), 18 patients with normal cognitive (PDN), 18 patients with probable mild cognitive impairment (ADMCI), and 25 healthy older controls (HC) underwent PCC1H-MRS scans. Compared with controls, patients with PDMCI exhibited significantly reduced concentration of N-acetyl aspartate (NAA) and total Creatine (tCr), while patients with ADMCI exhibited significantly increased concentration of myo-inositol (Ins), and reduced NAA/Ins ratio. There was reduced concentration of NAA, Ins and tCr in PDMCI compared with ADMCI. No significant metabolic alteration was found in PDN subjects. Besides, ROC analysis revealed that the concentration of tCr could differentiate PDMCI from PDN with an AUC of 0.71, and the level of NAA/Ins ratio could differentiate subjects with MCI from normal cognitive controls with an AUC of 0.74. Patients with PDMCI and ADMCI exhibited distinct PCC metabolic1H-MRS profiles. Findings suggest that cognitively normal PD patients with low NAA, tCr in the PCC might be at risk of preclinical PDMCI, and also the Ins and/or NAA/MI ratio in the PCC should be reconsidered as a possible biomarker of preclinical MCI in clinical practice. So, comparison of PCC1H-MRS profiles of cognitive impairment among neurodegenerative illnesses may provide useful information for better defining the disease process and elucidate possible treatment mechanisms.
A Postsurgical Prognostic Nomogram for Patients with Lymph Node Positive Rectosigmoid Junction Adenocarcinoma
Authors: Yanlong WU , Yibing Wang , Yunxiao Wu 
Published: November 2022

Abstract
Objective: The definition of rectosigmoid junction (RSJ) is still in debate. The treatment and prognosis of patients with rectosigmoid junction cancer (RSJC) and positive lymph nodes (PLN-RSJCs) are mostly based on the American Joint Committee on Cancer (AJCC) staging system. Our study aims to assist clinicians in creating a more intuitive and accurate nomogram model for PLN-RSJCs for the prediction of patient overall survival (OS) after surgery.
Methods: Based on the Surveillance, Epidemiology, and End Results (SEER) database, we extracted 3384 patients with PLN-RSJCs and randomly divided them into development (n=2344) and validation (n=1004) cohorts at a radio of 7:3. Using univariate and multivariate COX regression analysis, we identified independent risk factors associated with OS in PLN-RSJCs in the development cohort, which were further used to establish a nomogram model. To verify the accuracy of the model, the concordance index (C-index), receiver operating characteristic (ROC) curves, calibration curves, and an internal validation cohort have been employed. Decision curve analysis (DCA) was used to assess the clinical applicability and benefits of the generated model. Survival curves of the low- and high-risk groups were calculated using the Kaplan–Meier method together with the log-rank test.
Results: Age, marital, chemotherapy, AJCC stage, T and N stage of TNM system, tumor size, and regional lymph nodes were selected as independent risk factors and included in the nomogram model. The C-index of this nomogram in the development (0.751;0.737-0.765) and validation cohorts (0.750;0.764-0.736) were more significant than that of the AJCC 7th staging system (0.681; 0.665-0.697). The ROC curve with the calculated area under the curve (AUC) in the development cohort was 0.845,0.808 and 0.800 for 1-year, 3-year and 5-year OS, AUC in the validation cohort was 0.815,0.833 and 0.814 for 1-year, 3-year and 5-year, respectively. The calibration plots of both cohorts for 1-year,3-year and 5-year OS all demonstrated good agreement between actual clinical observations and predicted outcomes. In the development cohort, the DCA showed that the nomogram prediction model is more advantageous for clinical application than the AJCC 7th staging system. Kaplan-Meier curves in the low and high groups showed significant differences in patient OS.
Conclusions: We established an accurate nomogram model for PLN-RSJCs, intended to support clinicians in the treatment and follow-up of patients.
Ectopic Expression of Jatropha curcas JcTAW1 Improves the Vegetative Growth, Yield, and Drought Resistance of Tobacco
Authors: Peng Qingyan , Liu Chang , Zou Zhurong , Zhang Mengru 
Published: November 2022

Abstract
Jatropha curcas is a promising alternative bio-energy resource. However, underrun limited its broad application in the industry. Luckily, TAW1 is a high-productivity promoting gene that increases the lateral branches by prolonging the identification of inflorescence meristems to generate more spikes and flowers. In the current study, we introduced the Jatropha JcTAW1 gene into tobacco to depict a complete functional profile of the JcTAW1. Ectopic expressed JcTAW1 increased the lateral branches and ultimate yield of the transgenic tobacco plants. Moreover, the JcTAW1 lines observed a significantly higher plant height, longer roots, and better drought resistance. We performed RNA sequencing and weighted gene co-expression network analysis to determine which biological processes are affected by aberrant mutations in JCTAW1. We conclude that two up-regulated genes affect glucose metabolism and cell wall biosynthesis, and five down-regulated genes are involved in the negative regulation of DNA repair and TOR signaling. Biological processes such as carbon metabolism, cell wall biosynthesis, and ionization transport strongly affect the abnormal expression of JCTAW1. These findings indicate that JcTAW1 might drive the energy stream flowing to boost growth in three ways: (1) directly strengthening the energy metabolism cell proliferation; (2) improving the nutrient status by enhancing ion transport processes and releasing the TOR pathway from the negative regulation; (3) suppressing the DNA repair system to facilitate the cell proliferation.
Application of Analytic Network Process (ANP), Local and Indigenous Knowledge in mapping flood vulnerability in an informal settlement
Authors: Membele Garikai Martin , Naidu Maheshvari , Mutanga Onismo 
Published: November 2022

Abstract
In developing countries, informal settlements are mainly located in floodplains and wetlands, hence, they are frequently affected by floods. The objective of this study is to demonstrate a methodological approach that integrates the community members’ local and indigenous knowledge and GIS-based Multi-Criteria Decision Making using the Analytic Network Process (ANP) in mapping flood vulnerability in an informal settlement. The study was conducted in Quarry Road West informal settlement located in Durban, South Africa. A mixed-method approach that involved a household survey (n = 359), interviews with key informants (n = 10) and focus group discussions (n = 2) were used in this study. The results of this study showed that there is a spatial differentiation of flood vulnerability in the study area. Households along the Palmiet River were highly vulnerable to flooding. A section of the settlement called Mcondo 1 was also highly vulnerable to flooding while maMsuthu had low flood vulnerability. The sensitivity analysis results showed that changing the indicator weights, correspondingly, affected the output of the flood vulnerability map. Therefore, this study can serve as a guide for decision-makers on how to elicit adequate community participation and comprehensively integrate local and indigenous knowledge with Geographical Information System in mapping flood vulnerability in informal settlements.
Comparative genomic analysis of five Coprinus species
Authors: Wang Jingjing , Zhang Ran , Ding Guoao , Wang Lingling , Wang Wei , Zhang Yan , Zhu GuiLan 
Published: November 2022

Abstract
Background: Although Coprinus is widely known for the phenomenon of deliquescence and production of fungal laccases and extracellular peroxygenases, the genome structure and genetic diversity of Coprinus species have not been extensively studied. To reveal the genomic structure and diversity in Coprinus species, the genomes of five Coprinusspecies were compared and analyzed.
Results: A total of 24,303 orthologous gene families, including 89,462 genes, were identified in the five species. The numbers of core, softcore, dispensable, and private genes were 5617 (25.6%), 1628 (7.4%), 2083 (9.5%), and 12574 (57.4%), respectively. Differentiation time analysis revealed that Coprinellus micaceus and Coprinellus angulatusdifferentiated approximately 181.0 million years ago. Coprinopsis cinerea and Coprinopsis marcescibilis differentiated approximately 131.0 million years ago, and they were differentiated from Candolleomyces aberdarensisapproximately 176.0 million years ago. Gene family contraction and expansion analyses showed that 1,465 genes and 532 gene families were expanded, and 95 genes and 134 gene families were contracted. Ninety-five laccase-coding genes were detected in the five species, and the distribution of the laccase-coding genes in the five species was not uniform.
Conclusion: These data provide a reference for a deeper understanding of the genetic structure of the genomes of Coprinus species. Furthermore, this study provides a reference for follow-up studies on the genome structure of Coprinus species and the diversity of specific functional genes.
Identification of key genes and pathways in atherosclerosis using integrated bioinformatics analysis
Authors: Li Shihuan , Li Suqin , Li Qingjie , Zhou Qiaofeng , Liao Wenli , Yu Liangzhu , Ouyang Changhan , Xia hongli , Liu Chao , Li Mincai 
Published: November 2022

Abstract
Atherosclerosis (AS) is a chronic inflammatory disease that might induce severe cardiovascular events, such as myocardial infarction and cerebral infarction. These risk factors in the pathogenesis of AS remain uncertain and further research is needed. This study aims to explore the potential molecular mechanisms of AS by bioinformatics analyses. GSE100927 gene expression profiles, including 69 AS samples and 35 health controls, were downloaded from Gene Expression Omnibus (GEO) database. A total of 443 differentially expressed genes (DEGs) between control and AS were identified, including 323 down-regulated genes and 120 up-regulated genes. For GO term analyses, the up-regulated DEGs were enriched regulation of leukocyte activation, endocytic vesicle, and cytokine binding, while the down-regulated DEGs were enriched in negative regulation of cell growth, extracellular matrix, and G protein-coupled receptor binding. KEGG pathway analysis showed that the up-regulated DEGs were enriched in Osteoclast differentiation and Phagosome, while the down-regulated DEGs were enriched in vascular smooth muscle contraction and cGMP-PKG signaling pathway. The modular analysis of Cytoscape identified 3 modules were Leishmaniasis and Osteoclast differentiation. The GSEA analysis showed the up-regulated gene sets were enriched in the ribosome, ascorbated metabolism, and propanoate metabolism. The LASSO Cox regression analysis showed the top 3 genes were TNF, CX3CR1 and COL1R1. Finally, we found these immune cells were conferred significantly higher infiltrating density in the AS group. Our data showed the pathway of Osteoclast differentiation and Leishmaniasis were involved in the AS process and we developed three-gene model base on the prognosis of AS. These findings clarified the gene regulatory network of AS and may provide a novel target for AS therapy.