bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of the effects of Coriolis force and thermal radiation on water-based hybrid nanofluid flow over an exponentially stretching plate
Authors: Oke A. S. , Prasannakumara B. C. , Mutuku W. N. , Gowda R. J. Punith , Juma B. A. , Kumar R. Naveen , Bada O. I. 
Published: December 2022

AbstractHybrid nanofluids’ enhanced thermophysical properties make them applicable in a plethora of mechanical and engineering applications requiring augmented heat transfer. The present study focuses on a three-dimensional Copper-Aluminium Oxide$$\left( Cu\text{- }Al_{2}O_{3}\right)$$Cu-Al2O3-water based hybrid nanofluid flow within the boundary layer with heat transfer over a rotating exponentially stretching plate, subjected to an inclined magnetic field. The sheet rotates at an angular velocity$$\Omega$$Ωand the angle of inclination of the magnetic field is$$\gamma$$γ. Employing a set of appropriate similarity transformation reduces the governing PDEs to ODEs. The resulting ODEs are solved with the finite difference code with Shooting Technique. Primary velocity increases at large rotation but the secondary velocity reduces as the rotation increases. In addition, the magnetic field is found to oppose the flow and thereby causing a reduction in both the primary and secondary velocities. Increasing the volume fraction reduces the skin friction coefficient and enhances the heat transfer rate.
Impact of leukoaraiosis or blood pressure on clinical outcome, mortality and symptomatic intracerebral hemorrhage after mechanical thrombectomy in acute ischemic stroke
Authors: Göthel-Ezzeiani Annika , Jansen Olav , Austein Friederike , Hofmann Amelie , Berg Daniela , Meyne Johannes , Hensler Johannes 
Published: December 2022

AbstractWe aimed to study the impact of leukoaraiosis (LA) and blood pressure (BP) on clinical outcome, mortality and symptomatic intracerebral hemorrhage (sICH) in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy (MT). We analyzed data retrospectively from 521 patients with anterior large vessel occlusion treated with MT. LA was dichotomized in 0–2 (absent-to-moderate) versus 3–4 (moderate-to-severe) according to the van Swieten scale. Various systolic (SBP) and diastolic (DBP) BP parameters during the first 24 h were collected. Multivariable logistic regressions were performed to identify predictors of a poor 90-day outcome, mortality and sICH. LA was significantly associated with poor outcome (OR 3.2; p < 0.001) and mortality (OR 3.19; p = 0.008), but not sICH (p = 0.19). Higher maximum SBP was significantly associated with poor outcome (OR per 10 mmHg increase = 1.21; p = 0.009) and lower mean DBP was a predictor of mortality (OR per 10 mmHg increase = 0.53; p < 0.001). In the univariate analysis high SBP variability was associated with poor outcome, mortality and sICH, but not in the multivariate model. There was no association between BP and sICH. Severity of LA, SBP variability, high maximum SBP and low DBP are associated with either poor outcome or mortality in AIS patients undergoing MT. However, neither LA nor BP were associated with sICH in our cohort. Thus, mechanisms of the negative impact on outcome remain unclear. Further studies on impact of BP course and its mechanisms and interventions are needed to improve outcome in patients undergoing MT.
Dietary supplementation with Moringa oleifera leaves extract reduces the impacts of sub-lethal fipronil in Nile tilapia, Oreochromis niloticus
Authors: Mahmoud Hemat K. , Farag Mayada R. , Reda Fayiz M. , Alagawany Mahmoud , Abdel-Latif Hany M. R. 
Published: December 2022

AbstractThis study assessed the restorative dietary effects of Moringa oleifera (MO) leaves extract against the negative impacts of sub-lethal fipronil (FIP) toxicity in Nile tilapia. To achieve this purpose, the growth, body composition, haemato-biochemical measurements, serum immunity, and antioxidant condition of Nile tilapia have been examined. Fish were arranged into 6 experimental groups in quadruplicates. Three groups were fed on diets supplemented with 0.0 (reference group), 1.0 (MO1), and 2.0 (MO2) g kg−1 of MO leaf extract. The other three groups were fed on the same MO levels and concomitantly subjected to a sub-lethal FIP concentration (4.2 µg L−1 for 3 h only per day) and defined as FIP, FIP + MO1, and FIP + MO2. The experiment lasted for 8 weeks. Results unveiled that growth parameters were significantly decreased alongside an increased feed conversion ratio in the FIP-intoxicated group. The moisture and crude protein (%) were decreased significantly together with a significant increase of the crude lipids (%) in the fish body of the FIP group. Sub-lethal FIP toxicity induced hypochromic anemia, leukopenia, hypoproteinemia, hypoalbuminemia, hypoglobulinemia, and hepato-renal failure (increased urea and creatinine concentrations, as well as ALT and AST enzymes). Exposure to sub-lethal FIP also induced (a) immunosuppression manifested by a decline in total IgM, complement C3, and lysozyme activities, (b) enzymatic antioxidant misbalance manifested by decreases in SOD and CAT activities, and (c) oxidative stress (declined T-AOC and elevated of MDA concentrations). On the other side, dietary supplementation with MO leaf extract in FIP + MO1 and FIP + MO2 groups noticeably modulated the aforementioned parameters. Therefore, we can conclude that dietary MO could reduce sub-lethal FIP toxicity in Nile tilapia with a possible recommendation for regular prophylaxis supplementation in Nile tilapia diets.
Clinical outcomes following surgical management of deep infiltrating endometriosis
Authors: Leborne Perrine , Huberlant Stephanie , Masia Florent , de Tayrac Renaud , Letouzey Vincent , Allegre Lucie 
Published: December 2022

AbstractThe main aim of the study was to evaluate severe post-operative complications following deep endometriosis surgery in a tertiary referral centre. This is a retrospective cohort study that included women who had surgery for deep infiltrating endometriosis between 1st January 2013 and 31st December 2019. Endometriosis was diagnosed based on clinical, imaging and histological parameters. We evaluated the rates of post-operative complications, potential risk factors for such complications and postoperative pregnancy rates. A total of 165 patients were included in the final analysis. The median follow-up was 63 (25–106) months. Thirty-seven patients (22.42%) had hysterectomy, 60 (36.81%) had ureterolysis and 44 (26.67%) had colorectal surgery. The overall and severe rates of post-operative complications were 16.20% (n = 23) and 2.42% (n = 4) respectively. Of the variables assessed, operative time and age were the only statistically significant risk factor for complications on multivariate analysis. Among women operated on for infertility, 34.5% (n = 20/58) got pregnant following surgery with 30% of these spontaneously. This study demonstrates acceptable overall and severe post-operative complications and pregnancy rates after deep endometriosis surgery. This information should help clinicians when counselling women to enable them making an informed choice about their management.
Development and validation of a new multiplex for upgrading Y-STRs population databases from 12 to 23 markers and its forensic casework application
Authors: Navarro-López Belén , Baeta Miriam , Granizo-Rodríguez Eva , Moreno-López O. , Kleinbielen Tamara , Ferragut Joana Francesca , Picornell Antònia , de Pancorbo Marian M. 
Published: December 2022

AbstractY chromosomal short tandem repeats (Y-STRs) are used in forensic investigations as a useful complementary tool to autosomal markers. The ongoing development of new kits with an increasing number of markers makes it necessary to update populations typed in the Y-STR Haplotype Reference Database to reach at least 23 Y-STRs. A novel Y-STR multiplex panel was developed to offer a cost-efficient alternative to update Y-STR haplotypes from 12 to 23 loci. This panel includes the eleven markers, DYS448, DYS456, DYS458, DYS635, Y-GATA H4, DYS576, DYS481, DYS549, DYS533, DYS570 and DYS643, as well as DYS385a/b for traceability purpose. Developmental validation of this panel was conducted following the recommendations of the Scientific Working Group on DNA Analysis Methods (SWGDAM), showing high sensitivity, tolerance to common inhibitors as well as high species specificity. It was efficient for degraded DNA samples and for detection of male mixtures. When applying it for extending the current data of the Ibiza population, both the discrimination capacity and the haplotype diversity increased from 0.5952 to 0.9048 and from 0.9808 to 0.9977, respectively. Together, the study demonstrates the suitability of this panel in forensic casework.
Blast resistance of RC tubular structure under internal ANFO explosion
Authors: Choi Seung-Jai , Lee Tae-Hee , Noor Norhazilan Md. , Kim Jang-Ho Jay 
Published: December 2022

AbstractThe degree of structural damage is significantly more severe when a blast occurs inside than outside of a structure. However, existing designs for RC structures such as reinforced concrete containment vessels (RCCV) do not include design features to protect the structure for internal blast. Therefore, the internal blast resistance capacity of RC structures is evaluated by performing internal blast tests on RC tubular structures. The main objective of the study was to observe and document the basic structural behavior data obtained from internal detonation tests. ANFO explosive charge weights of 15.88, 20.41, 22.68 and 24.95 kg were selected for a charge detonating at a cross section center of the mid-span of the specimen, giving a standoff distance to the inner wall surface of 1000 mm. The data acquisitions include blast pressure, deflection, strain, and crack pattern. When the explosive charge weight increased from 15.88 to 24.95 kg, the peak incident pressure and time duration increased from 0.1718 to 0.3394 MPa and from 5.856 to 5.981 ms, respectively. Then, the test data were used to predict the internal charge weight required to fail a real scale RCCV using simple assumptions and the test data. The results of the study are discussed in detail in the paper.
Development of a machine-learning algorithm to predict in-hospital cardiac arrest for emergency department patients using a nationwide database
Authors: Kim Ji Hoon , Choi Arom , Kim Min Joung , Hyun Heejung , Kim Sunhee , Chang Hyuk-Jae 
Published: December 2022

AbstractIn this retrospective observational study, we aimed to develop a machine-learning model using data obtained at the prehospital stage to predict in-hospital cardiac arrest in the emergency department (ED) of patients transferred via emergency medical services. The dataset was constructed by attaching the prehospital information from the National Fire Agency and hospital factors to data from the National Emergency Department Information System. Machine-learning models were developed using patient variables, with and without hospital factors. We validated model performance and used the SHapley Additive exPlanation model interpretation. In-hospital cardiac arrest occurred in 5431 of the 1,350,693 patients (0.4%). The extreme gradient boosting model showed the best performance with area under receiver operating curve of 0.9267 when incorporating the hospital factor. Oxygen supply, age, oxygen saturation, systolic blood pressure, the number of ED beds, ED occupancy, and pulse rate were the most influential variables, in that order. ED occupancy and in-hospital cardiac arrest occurrence were positively correlated, and the impact of ED occupancy appeared greater in small hospitals. The machine-learning predictive model using the integrated information acquired in the prehospital stage effectively predicted in-hospital cardiac arrest in the ED and can contribute to the efficient operation of emergency medical systems.
Engineering a two-gene system to operate as a highly sensitive biosensor or a sharp switch upon induction with β-estradiol
Authors: Zhou Tian , Liang Zhiying , Marchisio Mario Andrea 
Published: December 2022

AbstractThe human estrogen receptor has been used for about thirty years, in the yeast S. cerevisiae, as a component of chimeric transcription factors. Its ligand, β-estradiol, permits to control the protein translocation into the nucleus and, as a consequence, the expression of the gene(s) targeted by the synthetic transcription factor. Activators that are orthogonal to the yeast genome have been realized by fusing the human estrogen receptor to an activation and a DNA-binding domain from bacteria, viruses, or higher eukaryotes. In this work, we optimized the working of a β-estradiol-sensing device—in terms of detection range and maximal output signal—where the human estrogen receptor is flanked by the bacterial protein LexA and either the strong VP64 (from herpes simplex virus) or the weaker B42 (from E. coli) activation domain. We enhanced the biosensor performance by thoroughly engineering both the chimeric activator and the reporter protein expression cassette. In particular, we constructed a synthetic promoter—where transcription is induced by the chimeric activators—based on the core sequence of the yeast CYC1 promoter, by tuning parameters such as the length of the 5′ UTR, the distance between adjacent LexA binding sites (operators), and the spacing between the whole operator region and the main promoter TATA box. We found a configuration that works both as a highly sensitive biosensor and a sharp switch depending on the concentration of the chimeric activator and the strength of its activation domain.
Timing of hypoxia PET/CT imaging after 18F-fluoromisonidazole injection in non-small cell lung cancer patients
Authors: Bourigault Pauline , Skwarski Michael , Macpherson Ruth E. , Higgins Geoff S. , McGowan Daniel R. 
Published: December 2022

AbstractPositron emission tomography (PET)/computed tomography (CT) using the radiotracer 18F-Fluoromisonidazole (FMISO) has been widely employed to image tumour hypoxia and is of interest to help develop novel hypoxia modifiers and guide radiation treatment planning. Yet, the optimal post-injection (p.i.) timing of hypoxic imaging remains questionable. Therefore, we investigated the correlation between hypoxia-related quantitative values in FMISO-PET acquired at 2 and 4 h p.i. in patients with non-small cell lung cancer (NSCLC). Patients with resectable NSCLC participated in the ATOM clinical trial (NCT02628080) which investigated the hypoxia modifying effects of atovaquone. Two-hour and four-hour FMISO PET/CT images acquired at baseline and pre-surgery visits (n = 58) were compared. Cohort 1 (n = 14) received atovaquone treatment, while cohort 2 (n = 15) did not. Spearman’s rank correlation coefficients (ρ) assessed the relationship between hypoxia-related metrics, including standardised uptake value (SUV), tumour-to-blood ratio (TBR), and tumour hypoxic volume (HV) defined by voxels with TBR ≥ 1.4. As the primary imaging-related trial endpoint used to evaluate the action of atovaquone on tumour hypoxia in patients with NSCLC was change in tumour HV from baseline, this was also assessed in patients (n = 20) with sufficient baseline 2- and 4-h scan HV to reliably measure change (predefined as ≥ 1.5 mL). Tumours were divided into four subregions or distance categories: edge, outer, inner, and centre, using MATLAB. In tumours overall, strong correlation (P < 0.001) was observed for SUVmax ρ = 0.87, SUVmean ρ = 0.91, TBRmax ρ = 0.83 and TBRmean ρ = 0.81 between 2- and 4-h scans. Tumour HV was moderately correlated (P < 0.001) with ρ = 0.69 between 2- and 4-h scans. Yet, in tumour subregions, the correlation of HV decreased from the centre ρ = 0.71 to the edge ρ = 0.45 (P < 0.001). SUV, TBR, and HV values were consistently higher on 4-h scans than on 2-h scans, indicating better tracer-to-background contrast. For instance, for TBRmax, the mean, median, and interquartile range were 1.9, 1.7, and 1.6–2.0 2-h p.i., and 2.6, 2.4, and 2.0–3.0 4-h p.i., respectively. Our results support that FMISO-PET scans should be performed at 4 h p.i. to evaluate tumour hypoxia in NSCLC.Trial registration: ClinicalTrials.gov, NCT02628080. Registered 11/12/2015, https://clinicaltrials.gov/ct2/show/NCT02628080.
A novel MPPT design based on the seagull optimization algοrithm for phοtovοltaic systems operating under partial shading
Authors: Chalh Abdelilah , chaibi Redouane , Hammoumi Aboubakr El , Motahhir Saad , Ghzizal Abdelaziz El , Al-Dhaifallah Mujahed 
Published: December 2022

AbstractThe use of a maximum power point (MPP) tracking (MPPT) controller is required for photovoltaic (PV) systems to extract maximum power from PV panels. However, under partial shading conditions, the PV cells/panels do not receive uniform insolation due to several power maxima appear on the PV array's P–V characteristic, a global MPP (GMPP) and two or more local MPPs (LMPPs). In this scenerio, conventional MPPT methods, including pertub and observe (P&O) and incremental conductance (INC), fail to differentiate between a GMPP and a LMPP, as they converge on the MPP that makes contact first, which in most cases is one of the LMPPs. This results in considerable energy loss. To address this issue, this paper introduces a new MPPT method based on the Seagull Optimization Algorithm (SOA) to operate PV systems at GMPP with high efficiency. The SOA is a new member of the bio-inspired algorithms. When compared to other evolutionary techniques, it uses fewer operators and modification parameters, which is advantageous when considering the rapid design process. In this paper, the SOA-based MPPT scheme is first proposed and then implemented for an 80 W PV system using the MATLAB/SIMULINK environment. The effectiveness of the SOA based MPPT method is verified by comparing its performance with P& O and PSO (particle swarm optimization) based MPPT methods under different shading scenarios. The results demonstrated that the SOA based MPPT method performs better in terms of tracking accuracy and efficiency.
Association of serum xanthine oxidase levels with hypertension: a study on Bangladeshi adults
Authors: Miah Rakib , Fariha Khandaker Atkia , Sony Sabrina Amita , Ahmed Shamim , Hasan Mahmudul , Mou Ananya Dutta , Barman Zitu , Hasan Akibul , Mohanto Nayan Chandra , Ali Nurshad 
Published: December 2022

AbstractXanthine oxidase (XO) is a metalloflavoenzyme associated with the uric acid formation in purine metabolism. Serum XO has been suggested to be associated with liver and kidney dysfunction, diabetes and cardiovascular diseases. However, there is limited information on the relationship between serum XO levels and hypertension. This study aimed to assess the relationship between serum XO levels and hypertension in Bangladeshi adults. In this study, fasting blood samples were collected from 312 participants (225 males and 87 females), aged ≥ 20 years. Serum levels of XO were determined by ELISA and other biochemical parameters including serum uric acid (SUA) were measured by colorimetric methods. Hypertension was defined as SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg or self-reported recent use of anti-hypertensive medications. Association between serum XO levels and hypertension was evaluated by multinomial logistic regression analysis. The mean level of XO was significantly higher (p < 0.001) in females (5.8 ± 3.2 U/L) than in males (3.9 ± 2.5 U/L). When the participants were divided by blood pressure levels, the mean level of serum XO was significantly higher (p < 0.01) in the hypertensive group (5.0 ± 2.7 U/L) compared to the normotensive control group (4.0 ± 2.7 U/L). An increasing trend for SBP and DBP levels was observed across the XO quartiles (at least p < 0.01 for both cases). A significant positive correlation was found for XO with SBP and DBP (p < 0.01). In regression analysis, the serum levels of XO showed a significant and independent association with hypertension prevalence. In conclusion, the mean level of serum XO was significantly higher in hypertensive individuals and XO was independently associated with the prevalence of hypertension. Our results indicate that XO may have a potential role in the pathophysiology of elevated blood pressure through generating of reactive oxygen species. Further large-scale longitudinal studies are needed to determine the underlying mechanisms between XO and hypertension.
Location management for the supply of PD fluid via large neighborhood search based virus optimization algorithm
Authors: Atthirawong Walailak , Luangpaiboon Pongchanun 
Published: December 2022

AbstractThe facility location problem is extended by a new two-stage zero-one programming system (2S-ZOPS). It is a type of design optimization issue that exists in logistics implementations such as supply chain planning in healthcare or agriculture. Along with concerns regarding PD delivery time manner for connecting logistics centers and customers, recent studies have considered the zero-one location design model. This research discussed a route selection model for the 2S-ZOPS that did not exist in the published studies by taking into account the level of risk associated with physical appearance. The mathematical models were developed in response to a PD supply chain design that occurred in Thailand’s National Health Insurance Program. By combining the virus optimization algorithm (VOA) with a large neighborhood search (LNS), we created a hybrid metaheuristic method for solving the 2S-ZOPS. Experiments with real-world data demonstrated that the hybrid algorithm was efficient in terms of time consumption and solution quality, saving approximately 6% on total costs. The presented practice benefits not only the healthcare industry but also various other businesses.
Rail induced lateral migration of particles across intact co-flowing liquids
Authors: Ziemecka Iwona , de Hemptinne Amaury , Misko Vyacheslav R. , Briet Matthieu , Gelin Pierre , Bihi Ilyesse , Maes Dominique , De Malsche Wim 
Published: December 2022

AbstractThis paper presents a rail guided method to apply a Layer-by-Layer (LbL) coating on particles in a microfluidic device. The passive microfluidic approach allows handling suspensions of particles to be coated in the system. The trajectory of the particles is controlled using engraved rails, inducing lateral movement of particles while keeping the axially oriented liquid flow (and the interface of different liquids) undisturbed. The depth and angle of the rails together with the liquid velocity were studied to determine a workable geometry of the device. A discontinuous LbL coating procedure was converted into one continuous process, demonstrating that the chip can perform seven consecutive steps normally conducted in batch operation, further easily extendable to larger cycle numbers. Coating of the particles with two bilayers was confirmed by fluorescence microscopy.