bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors controlling the transfer of biogenic organic species from seawater to sea spray aerosol
Authors: Santander Mitchell V. , Schiffer Jamie M. , Lee Christopher , Axson Jessica L. , Tauber Michael J. , Prather Kimberly A. 
Published: March 2022

AbstractOcean waves transfer sea spray aerosol (SSA) to the atmosphere, and these SSA particles can be enriched in organic matter relative to salts compared to seawater ratios. A fundamental understanding of the factors controlling the transfer of biogenic organic matter from the ocean to the atmosphere remains elusive. Field studies that focus on understanding the connection between organic species in seawater and SSA are complicated by the numerous processes and sources affecting the composition of aerosols in the marine environment. Here, an isolated ocean–atmosphere system enables direct measurements of the sea–air transfer of different classes of biogenic organic matter over the course of two phytoplankton blooms. By measuring excitation–emission matrices of bulk seawater, the sea surface microlayer, and SSA, we investigate time series of the transfer of fluorescent species including chlorophyll-a, protein-like substances, and humic-like substances. Herein, we show the emergence of different molecular classes in SSA at specific times over the course of a phytoplankton bloom, suggesting that SSA chemical composition changes over time in response to changing ocean biological conditions. We compare the temporal behaviors for the transfer of each component, and discuss the factors contributing to differences in transfer between phases.
Neural stem cell therapy in conjunction with curcumin loaded in niosomal nanoparticles enhanced recovery from traumatic brain injury
Authors: Narouiepour Abdolreza , Ebrahimzadeh-bideskan Alireza , Rajabzadeh Ghadir , Gorji Ali , Negah Sajad Sahab 
Published: March 2022

AbstractDespite a great amount of effort, there is still a need for reliable treatments of traumatic brain injury (TBI). Recently, stem cell therapy has emerged as a new avenue to address neuronal regeneration after TBI. However, the environment of TBI lesions exerts negative effects on the stem cells efficacy. Therefore, to maximize the beneficial effects of stem cells in the course of TBI, we evaluated the effect of human neural stem/progenitor cells (hNS/PCs) and curcumin-loaded niosome nanoparticles (CM-NPs) on behavioral changes, brain edema, gliosis, and inflammatory responses in a rat model of TBI. After TBI, hNS/PCs were transplanted within the injury site and CM-NPs were orally administered for 10 days. Finally, the effect of combination therapy was compared to several control groups. Our results indicated a significant improvement of general locomotor activity in the hNS/PCs + CM-NPs treatment group compared to the control groups. We also observed a significant improvement in brain edema in the hNS/PCs + CM-NPs treatment group compared to the other groups. Furthermore, a significant decrease in astrogliosis was seen in the combined treatment group. Moreover, TLR4-, NF-κB-, and TNF-α- positive cells were significantly decreased in hNS/PCs + CM-NPs group compared to the control groups. Taken together, this study indicated that combination therapy of stem cells with CM-NPs can be an effective therapy for TBI.
The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms
Authors: Nelissen Ellis , Possemis Nina , Van Goethem Nick P. , Schepers Melissa , Mulder-Jongen Danielle A. J. , Dietz Lisa , Janssen Wiebke , Gerisch Michael , Hüser Jörg , Sandner Peter , Vanmierlo Tim , Prickaerts Jos 
Published: March 2022

AbstractSoluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, a second messenger involved in memory formation, while heme-free sGC is inactive. Two compound classes can increase sGC activity: sGC stimulators acting on heme-bound sGC, and sGC activators acting on heme-free sGC. In this rodent study, we investigated the potential of the novel brain-penetrant sGC stimulator BAY-747 and sGC activator runcaciguat to enhance long-term memory and attenuate short-term memory deficits induced by the NOS-inhibitor L-NAME. Furthermore, hippocampal plasticity mechanisms were investigated. In vivo, oral administration of BAY-747 and runcaciguat to male Wistar rats enhanced memory acquisition in the object location task (OLT), while only BAY-747 reversed L-NAME induced memory impairments in the OLT. Ex vivo, both BAY-747 and runcaciguat enhanced hippocampal GluA1-containing AMPA receptor (AMPAR) trafficking in a chemical LTP model for memory acquisition using acute mouse hippocampal slices. In vivo only runcaciguat acted on the glutamatergic AMPAR system in hippocampal memory acquisition processes, while for BAY-747 the effects on the neurotrophic system were more pronounced as measured in male mice using western blot. Altogether this study shows that sGC stimulators and activators have potential as cognition enhancers, while the underlying plasticity mechanisms may determine disease-specific effectiveness.
The impact of healthcare reform on the dynamic changes in health service utilization and equity: a 10-year follow-up study
Authors: Guo Wenqin , Liu Gangjun , Ma Li , Gao Baokai , Wang Wenlong , Hu Zhaoyan , Tian Yanmei , Xiao Wenwen , Qiao Hui 
Published: March 2022

AbstractIn the past decade, the government of China has implemented healthcare reforms to provide universal access to healthcare by 2020. We aimed to systematically analyse the dynamic changes in health services and equity during the past 10 years to understand the correlation between health services and social-economic status. We performed a longitudinal study in which we extracted aggregated data mainly from a project (2009, 2011, 2012, 2015, 2019). A multi-stage stratified cluster randomized design was used to obtain a representative sample in each county. Concentration indexes were used to analyse the equity of the changes in utilization. We built multivariate random-effects generalized least squares regression models with the panel data to test whether the rate of receiving a medical consultation in the last 2 weeks or the rate of hospital admission or the prevalence of chronic illness was associated with social-economic status including education level and rural disposable income per capita. We found declines in both the rate of not receiving a medical consultation during the last 2 weeks (P < 0.05 intervention group) and the rate of hospital avoidance (P < 0.05) from 2009 to 2019. The equity in residents' health service utilization has improved constantly. We additionally found that rural disposable income per capita is a protective factor for the rate of a receiving a medical consultation during the last 2 weeks and the rate of hospital admission. China’s 2009 healthcare reform have positively influenced utilization rates and equity in health service utilization in the past decade, a range of health service-targeted strategies are needed including strengthen the prevention and treatment of chronic diseases, focus attention on the health status of elderly residents and improve social-economic status, especially the level of education.
Effect of low-level light therapy in patients with dry eye: a prospective, randomized, observer-masked trial
Authors: Park Yuli , Kim Hoon , Kim Sehwan , Cho Kyong Jin 
Published: March 2022

AbstractTo evaluate the efficacy of low-level light therapy (LLLT) with near-infrared light-emitting diodes (LED-LLLT) for the treatment of dry eye. 40 patients were randomly assigned with a 1:1 allocation ratio to receive LED-LLLT (LLLT group, n = 20) or placebo treatment (placebo group, n = 20). Patients in the LLLT group received LLLT twice a week for 3 weeks, for a total of 6 treatment sessions. The primary endpoint was the changes in the fluorescein corneal staining (FCS) score. The secondary endpoints were the changes in the ocular surface disease index (OSDI) score, lissamine green conjunctival staining (LGCS) scores, tear film break-up time (TBUT), Schirmer test, and the meibomian gland dysfunction (MGD) index. These were evaluated before treatment and 4 weeks after start of treatment. The mean difference of score change in primary endpoint revealed significant improvement in the LLLT group, compared to the placebo. Among secondary endpoints, LGCS, Schirmer's test, upper meibography scores showed significant improvements, while TBUT, lid debris, lid swelling, lid telangiectasia, meibomian gland secretion and expressibility scores had slight improvement without significant differences. No serious adverse events were observed. The use of LED-LLLT for the treatment of dry eye and MGD appears to be safe and beneficial.
The genome trilogy of Anopheles stephensi, an urban malaria vector, reveals structure of a locus associated with adaptation to environmental heterogeneity
Authors: Thakare Aditi , Ghosh Chaitali , Alalamath Tejashwini , Kumar Naveen , Narang Himani , Whadgar Saurabh , Paul Kiran , Shrotri Shweta , Kumar Sampath , Soumya M. , Rao Raksha , Chakraborty Mahul , Choudhary Bibha , Ghosh Susanta K. , Subramani Suresh , Swain Sunita , Srinivasan Subhashini 
Published: March 2022

AbstractAnopheles stephensiis the most menacing malaria vector to watch for in newly urbanising parts of the world. Its fitness is reported to be a direct consequence of the vector adapting to laying eggs in over-head water tanks with street-side water puddles polluted by oil and sewage. Large frequent inversions in the genome of malaria vectors are implicated in adaptation. We report the genome assembly of a strain ofAn. stephensiof the type-form, collected from a construction site from Chennai (IndCh) in 2016. The genome reported here with a L50 of 4, completes the trilogy of high-resolution genomes of strains with respect to a 16.5 Mbp 2Rbgenotype inAn. stephensiknown to be associated with adaptation to environmental heterogeneity. Unlike the reported genomes of two other strains, STE2 (2R+b/2Rb) and UCI (2Rb/2Rb), IndCh is found to be homozygous for the standard form (2R+b/2R+b). Comparative genome analysis revealed base-level details of the breakpoints and allowed extraction of 22,650 segregating SNPs for typing this inversion in populations. Whole genome sequencing of 82 individual mosquitoes from diverse geographical locations reveal that one third of both wild and laboratory populations maintain the heterozygous genotype of 2Rb. The large number of SNPs can be tailored to 1740 exonic SNPs enabling genotyping directly from transcriptome sequencing. The genome trilogy approach accelerated the study of fine structure and typing of an important inversion inAn. stephensi, putting the genome resources for this understudied species on par with the extensively studied malaria vector,Anopheles gambiae. We argue that the IndCh genome is relevant for field translation work compared to those reported earlier by showing that individuals from diverse geographical locations cluster with IndCh, pointing to significant convergence resulting from travel and commerce between cities, perhaps, contributing to the survival of the fittest strain.
Elevated lipoprotein(a) and genetic polymorphisms in the LPA gene may predict cardiovascular events
Authors: Gu Jun-Xu , Huang Juan , Li Shan-Shan , Zhou Li-Hua , Yang Ming , Li Yang , Zhang Ai-Min , Yin Yue , Zhang Na , Jia Mei , Su Ming 
Published: March 2022

AbstractElevated lipoprotein(a) [Lp(a)] is a risk factor for coronary heart disease (CHD), but there are few studies on the prediction of future cardiovascular events by Lp(a) and its LPA single nucleotide polymorphisms (SNPs). The aim of this study was to investigate whether elevated Lp(a) and its SNPs can predict cardiovascular events. We evaluated whether Lp(a) and LPA SNPs rs6415084 and rs12194138 were associated with the incidence rate and severity of CHD. All participants were followed up for 5 years. Elevated Lp(a) is an independent risk factor for the risk and severity of CHD (CHD group vs. control group: OR = 1.793, 95% CI: 1.053–2.882, p = 0.043; multiple-vessel disease group vs. single-vessel disease group: OR = 1.941, 95% CI: 1.113–3.242, p = 0.027; high GS group vs. low GS group: OR = 2.641, 95% CI: 1.102–7.436, p = 0.040). Both LPA SNPs were risk factors for CHD, and were positively associated with the severity of CHD (LPA SNPs rs6415084: CHD group vs. control group: OR = 1.577, 95% CI: 1.105–1.989, p = 0.004; multiple-vessel disease group vs. single-vessel disease group: OR = 1.613, 95% CI: 1.076–2.641, p = 0.030; high GS group vs. low GS group: OR = 1.580, 95% CI: 1.088–2.429, p = 0.024; LPA SNPs rs12194138: CHD group vs. control group: OR = 1.475, 95% CI: 1.040–3.002, p = 0.035; multiple-vessel disease group vs. single-vessel disease group: OR = 2.274, 95% CI: 1.060–5.148, p = 0.038; high GS group vs. low GS group: OR = 2.067, 95% CI: 1.101–4.647, p = 0.021). After 5 years of follow-up, elevated Lp(a) and LPA SNPs rs6415084 and rs12194138 can independently predict cardiovascular events. The increase of serum Lp(a) and LPA SNPs rs6415084 and rs12194138 are associated with increased prevalence and severity of CHD, and can independently predict cardiovascular events.
Inflammation and nutrition based screening tests for detection of infection in cases of rapid hip destruction
Authors: Abe Koki , Choe Hyonmin , Oba Masatoshi , Tezuka Taro , Ike Hiroyuki , Kobayashi Naomi , Inaba Yutaka 
Published: March 2022

AbstractPreoperative diagnosis of infection is important for appropriate surgical treatment of patients with rapid hip destruction (RHD). We investigated whether test results, including inflammatory and nutritional markers, could be used to accurately differentiate infectious and non-infectious RHD. Fifty patients with RHD who underwent total hip arthroplasty within a year of onset were observed. Infectious RHD was defined as ≥ 2 positive serological inflammatory, microbiological, or pathological evaluations. The albumin to globulin ratio (AGR), C-reactive protein (CRP)/albumin ratio (CAR), Glasgow prognostic score (GPS), modified GPS (mGPS), prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI), and platelet to lymphocyte ratio (PLR) were calculated from the blood test results. In the infectious group, the white blood cell count, platelet count, CRP level, erythrocyte sedimentation rate, CAR, GPS, mGPS, and PLR were significantly higher, while the albumin level, AGR, PNI, and GNRI were significantly lower. The CRP and albumin levels showed the highest sensitivity (1.00 for both; specificity of 0.87 and 0.73, respectively) in diagnosing infectious RHD. Combining these measurements (CAR) increased the specificity to 0.92. The accuracy of other nutritional assessments was good. Thus, nutritional assessment as well as conventional assessment of the inflammatory response can improve the accuracy of preoperative diagnosis of infectious RHD.
Clinical evaluation of ocular biometry of dual Scheimpflug analyzer, GALILEI G6 and swept source optical coherence tomography, ANTERION
Authors: Wanichwecharungruang Boonsong , Amornpetchsathaporn Anyarak , Kongsomboon Kittipong , Wongwijitsook Wisakorn , Annopawong Kornkamol , Chantra Somporn 
Published: March 2022

AbstractTo evaluate the performance of a new swept source optical coherence tomography optical biometer, ANTERION, in ocular biometry and intraocular lens (IOL) calculation compared with the reference standard of Dual Scheimpflug Analyzer (GALILEI, G6). A prospective comparative study was conducted in a tertiary eye center. Cataract patients were scanned with both devices in a random fashion, and parameters from the devices were analyzed in terms of mean difference and intraclass correlation coefficient (ICC). Bland–Altman plots were performed to compare agreement between the devices. Ninety-six eyes from 96 patients were enrolled for evaluation. With the exception of ACD, all parameters were significantly different, but excellent agreement was revealed for all of them. The mean difference in axial length was 0.03 mm, and ICC was 0.999. Calculated IOL power with Barrett formula revealed that 93.75% were within 1 diopter and the prediction error was 0.03 diopter. Biometry of the devices were arithmetically different. However, the mean difference of the key factors in IOL calculation were small and appeared to be negligible for the purposes of clinical application. The performance of ANTERION was comparable to that of G6 in biometric measurement and IOL calculation; however, the devices cannot be used interchangeably.
Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease
Authors: Jaago Mariliis , Pupina Nadežda , Rähni Annika , Pihlak Arno , Sadam Helle , Vrana Nihal Engin , Sinisalo Juha , Pussinen Pirkko , Palm Kaia 
Published: March 2022

AbstractCumulative evidence over the last decades have supported the role of gum infections as a risk for future major cardiovascular events. The precise mechanism connecting coronary artery disease (CAD) with periodontal findings has remained elusive. Here, we employ next generation phage display mimotope-variation analysis (MVA) to identify the features of dysfunctional immune system that associate CAD with periodontitis. We identify a fine molecular description of the antigenic epitope repertoires of CAD and its most severe form - acute coronary syndrome (ACS) by profiling the antibody reactivity in a patient cohort with invasive heart examination and complete clinical oral assessment. Specifically, we identify a strong immune response to an EBV VP26 epitope mimicking multiple antigens of oral biofilm as a biomarker for the no-CAD group. With a 2-step biomarker test, we stratify subjects with periodontitis from healthy controls (balanced accuracy 84%), and then assess the risk for ACS with sensitivity 71–89% and specificity 67–100%, depending on the oral health status. Our findings highlight the importance of resolving the immune mechanisms related to severe heart conditions such as ACS in the background of oral health. Prospective validation of these findings will support incorporation of these non-invasive biomarkers into clinical practice.
Seascapes of fear and competition shape regional seabird movement ecology
Authors: Courbin Nicolas , Pichegru Lorien , Seakamela Mduduzi , Makhado Azwianewi , Meÿer Michael , Kotze Pieter G. H. , Mc Cue Steven A. , Péron Clara , Grémillet David 
Published: March 2022

AbstractFear effects of predators on prey distributions are seldom considered in marine environments, especially over large spatial scales and in conservation contexts. To fill these major gaps, we tested the Seascape of Fear Hypothesis in the Benguela marine ecosystem off South Africa. Using electronic tracking data, we showed that Cape gannets and their predator, the Cape fur seal, co-occurred in daytime and competed with fisheries within coastal areas. At night, gannets are particularly vulnerable to seals, and 28% of the birds returned to the safety of their breeding colony. The remaining 72% slept at the sea surface, but shifted to offshore areas with lower seal attendance, reducing predation risk by 25%. Overall, our integrative study demonstrates how fear and competition shape the seascape of threatened Cape gannets within a marine environment perturbed by climate change and overfishing. Such knowledge has strong implications for the design of marine protected areas.
Fuel cell‐based topologies and multi‐input DC–DC power converters for hybrid electric vehicles: A comprehensive review
Authors: Pathak Pawan Kumar , Yadav Anil Kumar , Padmanaban Sanjeevikumar , Alvi P. A. , Kamwa Innocent 
Published: March 2022

AbstractIn the last few decades, the utilization of fuel cells (FCs) in the automotive industry has created much attention due to easy use, modular structure, and higher efficacy. In the future, technological evolutions reveal that FC driven electric vehicles (EVs) will grow at a rapid pace and will become an excellent alternative to conventional vehicles. This paper discusses a detailed topological classification of the FC‐based hybrid electric vehicle (FCHEV). In these FCHEVs, one of the critical elements is the DC–DC power converter unit. The hybridization of FCs with the other power sources requires more converter units that make the system complex. A multi‐input DC–DC power converter is used to connect more than one energy source to reduce the system's complexity and improve the overall system efficacy. In this survey, numerous articles have been considered and examined vividly. An assessment of present and future scenarios of FCs based power source topologies and multi‐input DC–DC power converter topologies used in HEV is presented. This survey provides a deep insight into the topic for the researchers and engineers working in this field.
Place de l'orthodontiste dans les soins apportés aux patients porteurs de fentes faciales, l'expérience Amiénoise
Authors: Bouallègue Imen , Gbaguidi Cica Carole 
Published: March 2022

La prise en charge des patients présentant des séquelles de fentes labio maxillo palatine est pluridisciplinaire et s'étale sur de nombreuses années. Elle nécessite une démarche diagnostique et un plan de traitement individualisé, raisonné et raisonnable où le traitement orthodontique prend une place importante en indiquant les directions des déplacements à réaliser au niveau dentaire et ceux éventuellement à prévoir au niveau squelettique.
C'est riche d'une longue expérience dans la mise en soins de nos patients que le centre de compétences des fentes faciales du CHU d'Amiens a affiné sa démarche clinique et son choix des facteurs décisionnels à prendre en compte selon les différentes situations cliniques afin de pallier le déficit esthétique inhérent à l'importante hypoplasie maxillaire et aux anomalies de nombre et de positions dentaires tout en optimisant la fonction occlusale et en pérennisant les structures parodontales.
L'objectif de cet article est de présenter la prise en charge orthodontique des patients porteurs de fentes dans le centre de compétences des fentes faciales du CHU d'Amiens et le rôle de l'orthodontiste au sein de l'équipe pluridisciplinaire
Facteurs de récidive et contention de la supraclusion incisive
Authors: Chabre Claude 
Published: March 2022

La supraclusion incisive est souvent citée par les auteurs comme étant la malocclussion la plus récidivante. Les facteurs de récidive sont en rapport avec le type de croissance, l'équilibre musculaire langue/lèvres et la dynamique occlusale.
La contention a pour but d'assurer la stabilité du résultat obtenu à l'issu du traitement actif de la malocclusion. Elle peut s'établir naturellement en fin de traitement si la dynamique occlusale permet à la mandibule d'effectuer de façon habituelle le mouvement d'incision mettant les incisives maxillaires et mandibulaires en bout à bout, seule position qui s'oppose à leur égression. En absence de certitude d'obtenir cette position, le recours à une contention mécanique s'impose. Différents dispositifs de contention peuvent être utilisés mais celui qui nous semble le plus adapté est l'association de fils de contention collés à la mandibule et au maxillaire en lingual des incisives, et des cales rétro-incisives en composite aux maxillaires.