bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perbandingan Model Pembelajaran Berbasis Masalah dan Model Pembelajaran Langsung terhadap Hasil Belajar Peserta Didik Kelas XI IPA SMA Negeri 1 Pancarijang Kab. Sidrap (Studi Pada Materi Pokok Hidrolisis Garam)
Authors: Hamzah Annisa , Yunus Muhammad , Sulfikar Sulfikar 
Published: July 2022

ABSTRAKPenelitian ini adalah penelitian eksperimen semu yang bertujuan untuk mengetahui ada atau tidaknya pengaruh model pembelajaran berbasis masalah terhadap hasil belajar peserta didik kelas XI IPA SMA Negeri 1 Pancarijang Kab. Sidrap pada materi pokok hidrolisis garam. Variabel bebas dalam penelitian ini adalah penggunaan model pembelajaran berbasis masalah pada kelas eksperimen 1 dan model pembelajaran langsung pada kelas eksperimen 2, sedangkan variabel terikatnya adalah hasil belajar peserta didik kelas XI IPA SMA Negeri 1 Pancarijang Kab. Sidrap pada materi pokok hidrolisis garam. Populasi dalam penelitian ini adalah kelas XI IPA SMA Negeri 1 Pancarijang tahun ajaran 2014/2015 yang terdiri dari 5 kelas. Pengambilan sampel dilakukan secara acak. Kelas yang terpilih sebagai sampel yaitu kelas XI IPA3 sebagai kelas eksperimen 1 dengan jumlah peserta didik 38 orang dan kelas XI IPA4 sebagai kelas eksperimen 2 dengan jumlah peserta didik 39 orang. Pengambilan data dilakukan dengan pemberian tes hasil belajar pada akhir pembelajaran. Pengujian hipotesis dengan uji Mann Whitney yang dilakukan pada α = 0,05 diperoleh nilai Zhitung (4,05) lebih besar dari Ztabel (1,64). Hal ini dapat disimpulkan bahwa penggunaan model pembelajaran berbasis masalah terhadap hasil belajar peserta didik kelas XI IPA SMA Negeri 1 Pancarijang Kab. Sidrap pada materi pokok hidrolisis garam menunjukkan hasil belajar yang lebih meningkat daripada penggunaan model pembelajaran langsung.Kata Kunci: Berbasis masalah, hasil belajar, pembelajaran langsung ABSTRACTThis research was a quasi-experimental that aimed to know whether or not the influence of problem based learning model towards student’s achievement at class XI IPA SMA Negeri 1 Pancarijang kab. Sidrap on hydrolysis of salt subject matter. The independent variables were problem based learning model in experimental 1 class and direct learning model in experimental 2 class, while the dependent variable was students’ achievement at XI IPA SMA Negeri 1 Pancarijang Kab. Sidrap in salt hydrolysis subject matter. The population was class XI IPA SMA Negeri 1 Pancarijang in academic year 2014/2015 consisted of 5 classes. Sampling was done randomly. The classes were chosen as sample were XI IPA3 as experimental 1 class with 38 students and XI IPA4 as experimental 2 class with 39 students. Data were collected by giving posttest. Testing the hypothesis with Mann Whitney test performed at α = 0,05 were obtained Zcalculated(4,05) was bigger than Ztable (1,64). Conclude that there was the influence of problem based learning model towards students’ achievement at class XI IPA SMA Negeri 1 Pancarijang Kab. Sidrap on hydrolysis salt subject matter.Keywords: Direct learning, problem based learning, students’ achievement
Pengaruh Ukuran Partikel terhadap Kualitas Briket Arang Tempurung Kelapa
Authors: Jaswella Rini Widya Ayu , Sudding Sudding , Ramdani Ramdani 
Published: July 2022

ABSTRAKPenelitian ini merupakan penelitian eksperimen yang bertujuan untuk mengetahui adanya pengaruh ukuran partikel serbuk arang terhadap kualitas briket arang tempurung kelapa. Penelitian dilakukan beberapa tahap yaitu pembuatan briket, analisis kadar air, kadar abu, nilai kalor dan lama waktu pembakaran. Pembuatan briket menggunakan ukuran partikel 30 mesh, 40 mesh, 50 mesh, 60 mesh dan 70 mesh. Hasil penelitian diperoleh bahwa semakin kecil ukuran partikel maka kualitas briket arang tempurung kelapa semakin menurun. Briket dengan ukuran partikel 70 mesh merupakan ukuran partikel terkecil. Berdasarkan SNI 01-6235-2000, briket tersebut masih termasuk berkualitas baik dengan kadar air 3,40%, kadar abu 2,40%, nilai kalor 6710 kal/g dan l ama waktu pembakaran 104 menit untuk satu briket dengan berat ± 7 gram.Kata kunci: Briket, ukuran partikel, kualitas briket ABSTRACTThis research was an experimental research that aimed to determine the effect of charcoal powder particle size to the quality of coconut shell charcoal briquettes. The research was conducted in several stages, i.e, production of briquettes, the analysis of moisture and ash content, calorific value and burning time. Briquettes was produced using the particle size of 30 mesh, 40 mesh, 50 mesh, 60 mesh and 70 mesh. The result showed that smaller particle size would reducing the quality of 70 mesh was the smallest particle size. Based on SNI 01-6235-2000, briquettes with the particle size of 70 mesh still classified as good quality briquettes with the moisture content of 3,40%, ash content of 2,40%, calorific value of 6710 cal/g and the burning time of 104 minutes for a briquette with weight of ± 7 grams.Keywords: Briquette, particle size, the quality of briquette
Molecular and genetic verification of von Willebrand disease type 2N
Authors: Chernetskaya D. M. , Surin V. L. , Salomashkina V. V. , Pshenichnikova O. S. , Yakovleva E. V. , Zozulya N. I. , Sudarikov A. B. , Likhacheva E. A. , Shabanova E. S. , Perina F. G. 
Published: July 2022

Introduction. Von Willebrand disease (vWD) is caused by von Willebrand factor (vWF) dysfunction resulting from pathogenic variants in the vWF gene coding the vWF protein. vWD type 2N is of particular interest, as it is characterized by almost normal vWF antigen level (Ag:vWF) and vWF loss of ability to bind FVIII and protect it from premature clearance, which leads to a low FVIII coagulation activity (FVIII:C). Therefore, the same phenotype occurs in patients with 2N type of vWD and hemophilia A.Aim — to identify patients with 2N type vWD using molecular genetic methods.Methods. Data from the medical histories of vWD patients were used. The major parameter in consideration was FVIII:C to vWF:Ag ratio, which is expected to be below 0.7 in type 2N of vWD. Pathogenic variants in exons and exon-intron junctions of the vWF gene were identified by Sanger sequencing. Due to recessive inheritance of type 2N, verification of the 2N vWD diagnosis required the identification of two pathogenic variants.Results. Three patients were considered as suffering from type 2N of vWD according to hemostasis parameters (FVIII:C/vWF:Ag < 0.7). One patient with a preliminary hemophilia A diagnosis was included after sequencing of the F8 gene, which showed no alterations, so 2N type of vWD was suspected. In all cases, sequencing of the relevant functional regions of the vWF gene led to verification of vWD type 2N. One woman (patient # 4) had a homozygous pathogenic variant p.Arg854Gln (c.2561 G>A) associated with type 2N vWD. One woman (patient # 3) was a compound heterozygote for the pathogenic variant p.Arg816Trp (c.2446 C>T) associated with type 2N and a newly described insertion c.2098_2099insG, that leads to a frameshift. The woman with FVIII:C/vWF:Ag < 0.7 (patient # 1) and the patient # 2 with preliminary hemophilia А diagnosis were both compound heterozygotes for the same combination of pathogenic variants — c.2435delC and p.Thr791Met (c.2372 C>T). Pathogenic variant p.Thr791Met is associated with type 2N, while the deletion c.2435delC should lead to allele disabling.Conclusion. Molecular methods allow more precise differentiation of type 2N from other types of vWD and hemophilia A.
Role of the intensive care in allogeneic hematopoietic stem cell transplantation
Authors: Shchekina A. E. , Galstyan G. M. , Drokov M. Y. 
Published: July 2022

Introduction. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is often complicated by life-threatening conditions.Aim — an analysis of the life-threatening complications in recipients of allogeneic hematopoietic stem cells (allo-HSCs)Main findings. From 10 to 50 % of allo-HSC recipients need to be admitted to the intensive care unit (ICU) due to the development of life-threatening complications. The reasons for ICU admission are acute respiratory failure, sepsis, graft-versus-host disease, veno-occlusive disease, thrombotic microangiopathy, cytokine release syndrome, engraftment syndrome, etc. Conditioning regimen, donor type, stem cell source, underlying disease state and patient comorbidity are the risk factors associated with development of life-threatening conditions. The main prognostic factors of unfavorable ICU outcomes in allo-HSC recipients are the severity of multiple organ dysfunction and the need for organ support.
Mechanisms of action of immunomodulatory drugs — from teratogenicity to treatment of multiple myeloma
Authors: Semochkin S. V. 
Published: July 2022

Introduction. Immunomodulatory drugs (IMiDs) are a class of chemical derivatives of thalidomide with numerous immunomodulatory, antiangiogenic, anti-inflammatory, and cytostatic effects in multiple myeloma (MM).Aim — to highlight the history of the discovery of IMiDs and discuss the molecular mechanisms of their therapeutic activity.Basic information. In 2010, more than half a century after the German company Chemie Grünenthal began the clinical use of thalidomide, the first understanding of the molecular mechanism of thalidomide and its structural derivatives appeared. Hiroshi Handa and colleagues from the Tokyo Medical University discovered that the drug thalidomide binds to the protein Cereblon (CRBN), a substrate receptor of the CRL4CRBN E3 ubiquitin ligase. Subsequent generations of immunomodulatory drugs (IMiDs) — lenalidomide and pomalidomide, are structurally like thalidomide. The glutarimide ring of IMiDs is inserted into the receptor pocket of the CRBN. In this case, the variable phthalimide part of the drug protrudes from the binding domain, changing the configuration of the CRBN in such a way that it allows it to interact with proteins (neosubstrates) with which it does not react under physiological conditions. It was later found that ubiquitin-mediated degradation of two transcription factors (Ikaros and Aiolos) underlies the antitumor and immunomodulatory activity of IMiDs, which have shown unique clinical efficacy in the treatment of multiple myeloma. A natural continuation of the success of IMiDs was the creation of a series of therapeutic molecules (Iberdomide, etc.) belonging to a new class of drugs called CELMoDs (Cereblon E3 Ligase Modulating Drugs). The presented literature review is devoted to the history of the discovery of IMiDs and a discussion of the molecular mechanisms of their therapeutic activity.
Management of patients with hemophilia A on emicizumab prophylactic treatment: Recommendation from Russian Experts
Authors: Andreeva T. A. , Zharkov P. A. , Zozulya N. I. , Zorenko V. Yu. , Konstantinova V. N. , Lebedev V. V. , Mamaev A. N. , Markova I. V. , Petrov V. Yu. , Polyanskaya T. Yu. , Schiller E. E. 
Published: July 2022

Introduction. In 2018 emicizumab was approved in Russia for prophylactic treatment in patients with hemophilia A (HA) with inhibitors and in 2019 for patients with severe HA without inhibitors. A significant amount of data has been accumulated from clinical trials and real-world data, which allow us to resolve most of the questions that hematologists may have when to prescribe emicizumab.Aim — to provide information on the management of patients on emicizumab.Results. The recommendations accumulated the currently available information and world experience in the management of patients receiving emicizumab in order to facilitate decision-making when prescribing and using emicizumab. Information on the use of emicizumab in patients with HA with FVIII inhibitors and severe HA without FVIII inhibitors is presented. Possible complications and measures for their prevention and treatment are presented.
InGaN-based green micro-LED efficiency enhancement by hydrogen passivation of the p-GaN sidewall
Authors: Kirilenko Pavel , Iida Daisuke , Zhuang Zhe , Ohkawa Kazuhiro 
Published: July 2022

Abstract
We investigated the effect of the sidewall passivation by hydrogen plasma on the InGaN green micro-LED performance. Hydrogen passivation deactivates the surface region of p-GaN around the perimeter of the device mesa. Thus, hole injection is suppressed in this region, where etching-caused material degradation results in leakage current, decreasing device efficiency. We have confirmed the hydrogen passivation effect on LED square pixels with sizes of 20 and 100 μm. For smaller LEDs, the reverse leakage current has reduced more than tenfold, and the external quantum efficiency of LEDs was enhanced 1.4-times due to the suppression of the non-radiative recombination.
Evaluación 360° de las tutorías presenciales y en línea en universidades públicas
Authors: Vázquez Cid de León Carlos , Domínguez Herrera José Ernesto , Aguilar Cruz Conrado , Ramírez Castillo Eric Amín , Vázquez Arango María de Lourdes 
Published: July 2022

Las Tutorías durante la pandemia COVID-19 reflejan casos de estudiantes con problemas y son cada vez más frecuentes tanto en las universidades públicas como en las privadas, la Universidad Tecnológica de la Mixteca no es la excepción ya que cuenta con un PIT de reciente creación de igual manera la Universidad Tecnológica del Centro de Veracruz. En el presente trabajo de investigación tiene por objetivo dar a conocer los resultados de la evaluación 360° aplicada hacia las tutorías en dos universidades públicas, se analizaron las tutorías en las diferentes carreras tales como: Ingeniería en Alimentos, Ingeniería en Computación, Ingeniería en Diseño, Ingeniería en Electrónica, Ingeniería en Mecatrónica, Ingeniería Industrial, Ingeniería en Física Aplicada, Ingeniería Mecánica Automotriz, Licenciatura en Ciencias Empresariales, Licenciatura en Matemáticas Aplicadas, Ingeniería Civil, en el caso de la Universidad Tecnológica del Centro de Veracruz cuenta con las carreras de: Agricultura Sustentable y Protegida, Nanotecnología, Energías Renovables, Desarrollo de Negocios, Tecnologías de la Información, Procesos Bioalimentarios, Gastronomía, Mecánica Automotriz, Logística, Mecatrónica, Mantenimiento Industrial, Turismo y Gestión Integral del Riesgo de Desastres. Existen áreas de oportunidad, se tiene la hipótesis que existen factores a considerar durante las tutorías a distancia o en línea y con respecto a las tutorías presenciales, la pandemia está afectando a los tutorados principalmente en el consumo de alcohol.
Said Nursi: A Brief Overview of Vision and Reformative Thoughts
Authors: Sethi Muhammad Bilal , Jalal Gulzar Ahmad , Haq Sami ul 
Published: July 2022

The focus of the article is Said Nursi’s contributions in the fields of education, religion, and politics. Nursi was a Kurdish theologian, an Islamic scholar, and the most popular and influential intellectual of Turkish history. His influence and popularity among people are indicative of the titles he received from the people including “Badiuz-Zaman” (Wonder of the Age) and “Ustaad” (Muallam or teacher). Besides this, Nursi was widely famous among his people for his extravagant memory: his long-term memory was able to reproduce certain books. This reflects upon his unordinary personality as he was able to recite many books from memory. An unusual narrative about him was that when he used to read a page of a book, he would learn it by heart at the same moment. His vast study, intelligence, powerful memory, and oratory skills impressed his contemporaries to a great extent.
INTELIGENCIA EMOCIONAL, ANSIEDAD Y DEPRESIÓN EN ESTUDIANTES UNIVERSITARIOS DURANTE LA PANDEMIA POR COVID-19
Authors: Montero Saldaña Bruno , López Ramírez Jose Pablo , Higareda Sánchez Jesús Javier 
Published: July 2022

El objetivo de la presente investigación fue relacionar la Inteligencia Emocional (IE) con sintomatología depresiva y ansiosa, además de con diversas variables sociodemográficas. Para esto, participaron 260 jóvenes universitarios con una edad media de 19.83 (DE=1.64), de los cuales 111 (42.7%) fueron hombres y 145 (55.8%) mujeres, todos estudiantes activos en modalidad en línea debido al aislamiento social a consecuencia del virus Sars-Cov2. Posteriormente, se utilizó la escala TMMS-24 para evaluar la autopercepción de la IE, la escala HARS para evaluar la ansiedad, por último, la escala PHQ9 para evaluar la sintomatología percibida de depresión. En conclusión, se encontró que la IE es un factor protector de sintomatología psicológica, pues se identificó una correlación negativa entre la IE y los síntomas de ansiedad y depresión. Adicionalmente, un ingreso familiar mensual bajo o estudiar en una universidad pública se correlacionó con menos habilidades de IE, y a su vez, con mayor sintomatología depresiva y ansiosa. En cuanto a diferencias por sexo, las mujeres indicaron mayor atención a sentimientos y niveles más altos en depresión y ansiedad, mientras que los hombres indicaron una mayor autopercepción de claridad y reparación emocional.
Muslim and Non-Muslim voices on Qur'an in the Light of the Clinton Bennett’s Work
Authors: Dr. Umm-e-Laila  , Alam Dr. Iftikhar , Dr. Muhammad Yasir  
Published: July 2022

Qur’an being the last divine book, has undergone a constant change of response from Muslim and non-Muslim scholars in the last fourteen centuries. Everybody has tried to understand Qur’an according to his own experiences and perceptions. These scholars have adopted various attitudes to understand and interpret the Qur’an and Qur’anic knowledges in every face of history. Clinton Bennett is one of the scholars who has compiled and analyzed the various approaches relating Qur’an. Moreover his coined hierarchy seems to be comparatively proper because he has divided the relative scholars into different categories according to his own classification.
Muslim attitudes include conservative (Traditionalists/Revivalists), Moderate (Liberal) and the Progressive ones, while non-Muslim attitudes consist of faith sensitive and critical ones. In addition to the elaborations of various scholastic attitudes Clinton Bennett has at times cited his own version therein.
In the study underhand we will try to discuss the hierarchy of the Quranic beliefs as visualized by Muslim and non-Muslim scholars. We will discuss the class and position of the scholars given by Clinton Bennett to them in his hierarchy and would narrate the contribution of the scholars hereafter. We will also examine and study the relative scholars by our own critical analyzation. This research is descriptive and analytical in nature and presents a detailed analysis of the work, it is based upon.
The Image of Pius XII in Modern Cinema (on the Example of the Film «Pius XII: Under the Roman Sky»)
Authors: Mordzilovich Anna 
Published: July 2022

The article is dedicated to the formation of the image of Pope Pius XII (1939–1958) in modern cinema. The author focuses on the film «Pius XII: Under the Roman Sky» («Sotto il cielo di Roma», 2010, directed by Christian Duguay), which tells about the story of the events during the German occupation of Rome in World War II. Besides, the article traces the evolution of the Pope’s image in cinema from the 1940s/1950s to the present day.
The first films about Pius XII appeared already during his lifetime and created a positive image of the Pope. For instance, the Italian director Romolo Marchellini portrayed the pontiff as a mediator of peace between peoples and as a «living saint».
Since the 1960s a negative image of Pius XII is being formed in the cinema. The reasons are the beginning of a critical rethinking of the Nazi past and the trials of Nazi criminals, during which new details of the Holocaust were revealed. The silence of Pius XII was criticized in a number of fiction books (Rolf Hochhut, Robert Katz), which later was used as a basis of several films. Among them, the most popular is the film «Amen» (2002, directed by Costa-Gavras).
The film «Pius XII: Under the Roman Sky» (2010) is one of the first attempts to overcome the negative image of Pius XII that has developed in cinema over the past years. Unlike previous films, here the pontiff is portrayed not only as a political, but also as a spiritual leader. Since the film is based on beatification documents, the Pope appears as an active defender of the Jews. This film and the features of the Pius XII’s image are analyzed in detail in the article.
It is concluded that the opening of Vatican archives on the pontificate of Pius XII may contribute to the further development of this Pope’s image in cinema.
The Circumgalactic Medium from the CAMELS Simulations: Forecasting Constraints on Feedback Processes from Future Sunyaev–Zeldovich Observations
Authors: Moser Emily , Battaglia Nicholas , Nagai Daisuke , Lau Erwin , Machado Poletti Valle Luis Fernando , Villaescusa-Navarro Francisco , Amodeo Stefania , Anglés-Alcázar Daniel , Bryan Greg L. , Dave Romeel , Hernquist Lars , Vogelsberger Mark 
Published: July 2022

Abstract
It is important to understand the cycle of baryons through the circumgalactic medium (CGM) in the context of galaxy formation and evolution. In this study, we forecast constraints on the feedback processes heating the CGM with current and future Sunyaev–Zeldovich (SZ) observations. To constrain these processes, we use a suite of cosmological simulations, the Cosmology and Astrophysics with MachinE Learning Simulations (CAMELS). CAMELS varies four different feedback parameters of two previously existing hydrodynamical simulations, IllustrisTNG and SIMBA. We capture the dependences of SZ radial profiles on these feedback parameters with an emulator, calculate their derivatives, and forecast future constraints on these feedback parameters from upcoming experiments. We find that for a galaxy sample similar to what would be obtained with the Dark Energy Spectroscopic Instrument at the Simons Observatory, all four feedback parameters can be constrained (some within the 10% level), indicating that future observations will be able to further restrict the parameter space for these subgrid models. Given the modeled galaxy sample and forecasted errors in this work, we find that the inner SZ profiles contribute more to the constraining power than the outer profiles. Finally, we find that, despite the wide range of parameter variation in active galactic feedback in the CAMELS simulation suite, we cannot reproduce the thermal SZ signal of galaxies selected by the Baryon Oscillation Spectroscopic Survey as measured by the Atacama Cosmology Telescope.
Constraining the Milky Way Halo Kinematics via Its Linear Response to the Large Magellanic Cloud
Authors: Rozier Simon , Famaey Benoit , Siebert Arnaud , Monari Giacomo , Pichon Christophe , Ibata Rodrigo 
Published: July 2022

Abstract
We model the response of spherical, nonrotating Milky Way (MW) dark matter and stellar halos to the Large Magellanic Cloud using the matrix method of linear response theory. Our computations reproduce the main features of the dark halo response from simulations. We show that these features can be well separated by a harmonic decomposition: the large-scale over/underdensity in the halo (associated with its reflex motion) corresponds to the ℓ = 1 terms, and the local overdensity to the ℓ ≥ 2 multipoles. Moreover, the dark halo response is largely dominated by the first-order forcing term, with little influence from self-gravity. This makes it difficult to constrain the underlying velocity distribution of the dark halo using the observed response of the stellar halo, but it allows us to investigate the response of stellar halo models with various velocity anisotropies: a tangential (respectively radial) halo produces a shallower (respectively stronger) response. We also show that only the local wake is responsible for these variations, the reflex motion being solely dependent on the MW potential. Therefore, we identify the structure (orientation and winding) of the in-plane quadrupolar (m = 2) response as a potentially good probe of the stellar halo anisotropy. Finally, our method allows us to tentatively relate the wake strength and shape to resonant effects: the strong radial response could be associated with the inner Lindblad resonance, and the weak tangential one with corotation.