bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artifacts in magnetic resonance imaging caused by dental materials: a systematic review
Authors: Bohner Lauren , Hanisch Marcel , Sesma Newton , Blanck-Lubarsch Moritz , Kleinheinz Johannes 
Published: March 2022

Objectives: The purpose of this systematic review was to search in literature in which severity unintended effects are caused by dental materials in magnetic resonance imaging (MRI), such as to evaluate whether these artifacts hamper the diagnosis in the head and neck region. Materials and Methods: Clinical studies showing the severity of artifacts which dental materials are capable of causing in MRI of head and neck, such as their influence on diagnostic accuracy, were included in this review. The searches were conducted in four electronic databases (PubMed/Medline, Embase, Scopus and Web of Science), and a manual search was made in the reference lists of papers screened for full-text reading. Risk of bias was assessed using “Quality Assessment Tool for Diagnostic Accuracy Studies-2” (QUADAS-2). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the quality of evidence. Results: From 151 studies selected for full-reading, 19 were considered eligible for this review. Artifacts caused by orthodontic appliances were well-documented, and stainless steel brackets were the materials most likely to cause artifacts in MR imaging of head and neck. The literature was scarce for dental implants and restorations. Diagnoses within the oral cavity, but also those of the brain and craniofacial structures, were affected. Conclusion: Artifacts caused by orthodontic appliances may affect the diagnosis in oral cavity and craniofacial structures. Data regarding dental implants and prosthodontics restorations were inconclusive. The severity of artifacts in MRI and their influence on diagnosis is dependent on dental material features, location in the oral cavity, and magnetic resonance parameters.
Induction-phase treatment costs for cryptococcal meningitis in high HIV-burden African countries: New opportunities with lower costs
Authors: Larson Bruce , Shroufi Amir , Muthoga Charles , Oladele Rita , Rajasingham Radha , Jordan Alexander , Jarvis Joseph N. , Chiller Tom M. , Govender Nelesh P. 
Published: March 2022

Introduction: Access to and the cost of induction treatment for cryptococcal meningitis (CM) is rapidly changing. The newly-announced price for flucytosine ($0.75 per 500 mg pill) and possibly lower prices for liposomal amphotericin B (AmB-L) create opportunities to reduce CM treatment costs compared to the current standard treatment in low- and middle-income countries. Methods: We developed an Excel-based cost model to estimate health system treatment costs for CM over a two-week induction phase for multiple treatment combinations, newly feasible with improved access to flucytosine and AmB-L. CM treatment costs include medications, laboratory tests and other hospital-based costs (bed-day costs and healthcare worker time). We report results from applying the model using country-specific information for South Africa, Uganda, Nigeria, and Botswana. Results: A 14-day induction-phase of seven days of inpatient AmB-D with flucytosine, followed by seven days of high-dose fluconazole as an outpatient, will cost health systems less than a 14-day hospital stay with AmB-D and fluconazole. If daily AmB-L replaces AmB-D for those with baseline renal dysfunction, with a cost of $50 or less per 50 mg vial, incremental costs would still be less than the AmB-D with fluconazole regimen. Simple oral combinations (e.g., seven days of flucytosine with fluconazole as an inpatient) are practical when AmB-D is not available, and treatment costs would remain less than the current standard treatment. Conclusions: Improved access to, and lower prices for flucytosine and AmB-L create opportunities for improving CM treatment regimens. An induction regimen of flucytosine and AmB-D for seven days is less costly than standard care in the settings studied here. As this regimen has also been shown to be more effective than current standard care, countries should prioritize scaling up flucytosine access. The cost of AmB-L based regimens is highly dependent on the price of AmB-L, which currently remains unclear.
Fuzzy Ethizität: Radar für ethische Künstliche Intelligenz
Authors: Kaufmann Michael , Meier Andreas 
Published: March 2022

ZusammenfassungEine Informations- und Wissensgesellschaft betreibt ihre Wertschöpfungskette primär durch Aufbau, Verarbeitung und Weitergabe von Informationen (digitalen Produkten und Dienstleistungen) respektive von Wissen (intelligenten Produkten und Wissensdienstleistungen). Mit Künstlicher Intelligenz angereicherte Produkte und Dienstleistungen erhöhen deren Verfügbarkeit und Sicherheit, indem Entscheidungen datenbasiert automatisiert werden. Allerdings müssen Ethikregeln berücksichtigt werden, um die Vertrauensbasis digitaler Gesellschaften zu stärken und nachhaltige Entwicklung zu fördern. Im Folgenden wird ein Radarsystem für die Bewertung der Ethizität im Digitalzeitalter vorgeschlagen mit dem Ziel, eine ethische Entwicklung von intelligenten Informationssystemen zum Wohl der Gemeinschaft zu überprüfen. Die sechs Dimensionen dieses Systems basieren auf der Grundlage von Menschenrechten und einer umfassenden Analyse bestehender Ethik-Rahmenwerke für Künstliche Intelligenz: Gleichheit & Gerechtigkeit, Schutz & Hilfe, Privatsphäre & Datenschutz, Freiheit & Autonomie, Solidarität & Nachhaltigkeit und Verantwortlichkeit & Transparenz. Der Beitrag diskutiert diese sechs Dimensionen digitaler Ethik und schlägt ein Radarsystem zur visuellen Analyse der Ethizität von intelligenten Informationssystemen vor. Danach wird das Radarsystem mithilfe der Fallstudie Privacy Setting Framework auf Nützlichkeit evaluiert. Ein Fazit des Beitrags summiert die Erkenntnisse.
Identification Method of Conductance Fluctuation Signal of Fiber Bragg Grating Bio-Sensor
Authors: Lu Xiaocui 
Published: March 2022

Abstract
Traditional conductance fluctuation signal recognition methods are difficult to realize multiresolution recognition, resulting in low recognition accuracy and efficiency. Therefore, a new conductance fluctuation signal recognition method of fiber Bragg grating sensor is proposed in this paper. Firstly, the conductance fluctuation signal of fiber Bragg grating sensor is extracted by wavelet transform; secondly, the conductance fluctuation signal is segmented by autocorrelation function to realize the five-level wavelet decomposition of conductance fluctuation signal; finally, the tower algorithm is used to realize the multiresolution identification of conductance fluctuation signal, and the identification of conductance fluctuation signal of fiber Bragg grating sensor is realized. In order to verify the effectiveness of this method, a comparative experiment is designed. The results show that this method can effectively improve the accuracy of signal feature recognition and reduce the time and delay of signal feature recognition.
El derecho al agua: El movimiento de las resistencias unidas contra la cervecera Constellation Brands
Authors: Márquez Fernando 
Published: March 2022

Los días 21 y 22 de marzo de 2020 se realizó la consulta ciudadana en Mexicali Baja California, México, donde se sometió a votación si la empresa cervecera transnacional Constellation Brands debía de seguir o no en Mexicali. En esta consulta ganó el rechazo a la Constellation (ganó el NO a la empresa), con un 76% (29.793 votos).
Esta consulta fue el resultado de una serie de factores, especialmente de las acciones del movimiento social de las resistencias unidas en defensa del agua en Baja California, surgido a partir de las protestas sociales en Mexicali en enero de 2017, cuyo principal objetivo era defender el agua en Mexicali, resistiendo las acciones de la cervecera transnacional para apropiarse de la misma.
Get out of the BAG! Silos in AI Ethics Education: Unsupervised Topic Modeling Analysis of Global AI Curricula
Authors: Javed Rana Tallal , Nasir Osama , Borit Melania , Vanhee Lois , Zea Elias , Gupta Shivam , Vinuesa Ricardo , Qadir Junaid 
Published: March 2022

The domain of Artificial Intelligence (AI) ethics is not new, with discussions going back at least 40 years. Teaching the principles and requirements of ethical AI to students is considered an essential part of this domain, with an increasing number of technical AI courses taught at several higher-education institutions around the globe including content related to ethics. By using Latent Dirichlet Allocation (LDA), a generative probabilistic topic model, this study uncovers topics in teaching ethics in AI courses and their trends related to where the courses are taught, by whom, and at what level of cognitive complexity and specificity according to Bloom’s taxonomy. In this exploratory study based on unsupervised machine learning, we analyzed a total of 166 courses: 116 from North American universities, 11 from Asia, 36 from Europe, and 10 from other regions. Based on this analysis, we were able to synthesize a model of teaching approaches, which we call BAG (Build, Assess, and Govern), that combines specific cognitive levels, course content topics, and disciplines affiliated with the department(s) in charge of the course. We critically assess the implications of this teaching paradigm and provide suggestions about how to move away from these practices. We challenge teaching practitioners and program coordinators to reflect on their usual procedures so that they may expand their methodology beyond the confines of stereotypical thought and traditional biases regarding what disciplines should teach and how.
This article appears in the AI & Society track.
Penerimaan Cergam Pakai Masker Yuk pada Guru Taman Kanak-Kanak di Kecamatan Blimbing Kota Malang
Authors: Ekawati Rany 
Published: March 2022

COVID-19 (coronavirus disease 2019) adalah penyakit yang disebabkan oleh jenis coronavirus baru yaitu Sars-CoV-2 dengan menunjukkan gejala gangguan pernafasan akut seperti demam diatas 38 derajat celcius, batuk dan sesak nafas bagi manusia. Metode pelaksanaan dalam penelitian ini dibagi menjadi empat bagian yaitu persiapan, pelaksanaan, monitoring dan evaluasi, pembuatan laporan. Jumlah kasus Positif covid-19 di Kecamatan Blimbing terbanyak dari pada kecamatan lain di Kota Malang sehingga anak-anak berisiko terkena Covid-19. Metode pelaksanaan dalam penelitian ini adalah deskriptif. Penelitian ini mengedukasi anak sekolah TK di Kecamatan Blimbing dengan cerita bergambar Pakai Masker Yuk agar mau menggunakan masker di masa pandemi COVID-19. Media edukasi cergam mendapaTKan respon dari guru yaitu isi cerita baik sebanyak 71 persen, kalimat yang digunakan baik sebanyak 61,3 persen, suara dalam video baik sebanyak 54,8 persen. Kesimpulan dalam penelitian ini yaitu sekolah TK yang berada di Kecamatan Blimbing dengan jumlah 31 TK mendapatkan edukasi dengan story telling Cerita Bergambar (cergam) Pakai Masker Yuk, dan dilengkapi dengan video edukasi yang menarik sehingga mendapatkan respon yang baik dari murid beserta guru.
ABNORMAL BLOOD LIPIDS LEVELS (DYSLIPIDEMIA) TREATMENT WITH ACUPUNCTURE METHOD
Authors: Rinjani Anissa Maulina , Septriana Maya , Herawati Lilik 
Published: March 2022

Background: Dyslipidemia is an abnormal lipid metabolism characterized by an increase in total cholesterol, LDL (Low-Density Lipoprotein), triglycerides (TG), and a decrease in HDL (High-Density Lipoprotein). Increased levels of total cholesterol, TG, LDL, and decreased HDL levels can increase the risk of cardiovascular disease. According to TCM, dyslipidemia is categorized into “Tan Zheng” (phlegm syndrome), “Shi Zuo” (damp retention), “Xuan Yun” (vertigo), and “Fei Pang” (obesity). Purpose: The purpose of this review is to analyze the literature study on TCM within the treatment of dyslipidemia with different acupuncture methods and points. The primary data search was conducted using online e-resources (Google Scholar, Proquest, and Pubmed). Review: The results of the study should include at least one of the outcomes indicators for total cholesterol, TG, LDL, and HDL. The result there were 20 journals consisting of studies that used several acupuncture methods, manual acupuncture (AM), electroacupuncture (EA), moxa (MOK), auricular acupuncture (AA), Cupping (CUP), and found additional interventions such as nutritional interventions, and exercise; body points often used are Zusanli (ST 36), Fenglong (ST 40), Quchi (LI 11), Daheng (SP15), Zhongwan (CV 12), Qihai (CV 6), Guanyuan (CV 4), Sanyinjiao (SP 6), Shenque (CV 8), Tianshu (ST 25), and therefore for AA are Spleen (CO 13), Stomach (CO 4), Shenmen (TF 4), and hunger point. Twenty journals showed a decrease in total cholesterol, TG, LDL levels, and an increase in HDL levels. Conclusion: In conclusion, all types of acupuncture methods can reduce total cholesterol, TG and LDL levels, and increase HDL levels.
survival rate comparison of non small cell lung carcinoma patients who are given by epidermal growth factor receptor-tyrosin kinase inhibitor and those given by first-line chemotherapy treatment
Authors: Nyambe Hasan , Santoso Arif , Tabri Nur Ahmad , Iskandar Harun , Ilyas Muh , Wiriyansyah Edward Pandu 
Published: March 2022

Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamous and squamous. Non-small cell lung cancer of non squamous types consist of adenocarcinoma and large cell carcinoma. Currently, lung cancer therapy is highly developed of chemotherapeutic agents to targeted therapy especially EGFR-TKI. This study aims to assess the survival rate of NSCLC patients who receive first line chemotherapy and those who recieve EGFR-TKI therapy at Wahidin Sudirohusodo hospital. Methods. This study is a retrospective study between 2017 to 2019 from the medical records of NSCLC patients who receive first-line chemotherapy and thise who recieve EGFR-TKI. Patients with platinum-based chemotherapy and EGFR-TKI with gefitinib therapy 1x250 mg/day or erlotinib 1x150mg/day and or afatinib 1x40 mg/day. Survival rate assessed from start to erect the diagnosis until the patient dies or when the study is discontinued. Result. From 239 subject of NSCLC patients consisted of 135 patients who receive first-line chemotherapy, and 104 patients are treate with EGFR-TKI. Based on the characteristics of the patients, most are more than 40 years old (chemotherapy 124 (91.9%) and EGFR-TKI 101 (97.1%) with the male gender that dominates (chemotherapy 98 (72.6%), EGFR-TKI 64 (61.5%). Smoking patients who received first-line chemotherapy are 65.2% and 61.5% of EGFR-TKIs with chemotherapy highest IB (severe IB 28.9%) and for EGFR-TKI (moderate IB are 26.9%). 73.2% of adenocarcinoma histology type with a predominance of stage IV 86.6% (83.7% for chemotherapy and EGFR-TKI 90.4%). Survival rate of patients are 98,7% for 6 months survival, 1 year survival rate is 94.1% and 2 years survival rate of 24.3%. Median survival patients who receiving EGFR-TKI longer than they received first- line chemotherapy (21 months versus 20 months). The 18 months PFS showed that patients treated with EGFR-TKI were 15 months, while patients receiving chemotherapy was 11 months. (P 0.000). Conclusion. Survival rates in NSCLC patients with EGFR-TKI therapy had significantly the highest survival rates compared with all other chemotherapy. Progression was faster in patients with first-line chemotherapy than EGFR-TKI. The factors that most influence the survival rate is type of therapy with p value<0.05.
Predictors of severe labor pain: prospective observational study.
Authors: Romanenko Anastasiia , Kuchyn Iurii , Govsieiev Dmytro , Bielka Kateryna 
Published: March 2022

Abstract
Introduction: Pain during childbirth is a complex and subjective experience that every mother experiences differently [1]. The degree of a woman's suffering in childbirth depends on the intensity of labor pain and many indirect factors [2]. Complex interrelated effects on labor pain are limited by the little number of studies available. That is why it is necessary to determine the probable factors that may affect the intensity of pain. In accordance with this, determining predictors of the intensity of pain during vaginal delivery remains an important issue for the maternity health policy.Aim: Investigate predictors of severe labor pain.Method: A prospective observational study was conducted in the period from December 2020 to May 2021 at the Kyiv City Maternity Hospital №5 (Kyiv, Ukraine). Logistic regression was used to measure the influence of risk factors on the probability of severe labor pain.Results: The examined predictors were derived from mothers` self-report of overall childbirth. 366 women took part in research, 282 of them rated their pain by ≤ 60 mm visual analog scale (VAS), while 84 patients reported their pain by ≥70 mm VAS. The study identified predictors that reduce the risk of severe labor pain, such as a woman's prenatal health (namely, a healthy prenatal woman) (OR 0.0967 [95% CI 0,0344 - 0,2719], p=0,0001), attendance of maternal school (OR 0.0978 [95% CI 0.0541 - 0.1767], p<0,0001), doula`s help (OR 0,1266 [95% CІ 0,0711 - 0,2255], p<0,0001) and feeling of control over pain in labor (OR 0,0176 [95% CІ 0,0086 - 0,0359], p<0,0001). In addition, predictors such as first delivery (OR 1.67 [95% CI 1.0240 - 2.7387], p=0,04) and prenatal anxiety (OR 9.1277 [95% CI 5.2973 - 15.7276], p<0,0001) in contrast to the factors listed above, increase the risk of severe labor pain. Conclusion: Significant predictors of severe labor pain were identified through this study. The findings are useful in the maternal care system by focusing on early prevention of treatment labor pain. ClinicalTrials.gov: Retrospectively registered on February 23, 2022, NCT05226208
Suppressing circ_0008494 inhibits HSC s activation by regulating the miR-185-3p/ Col1a1 axis
Authors: Li Binbin , Zhou Jiaming , Luo Yuanyuan , Tao kegong , Zhang Lifen , Lin Yong , Zeng Xing , Yu Hongyu 
Published: March 2022

Abstract
Background
Because of its viral nature and the increasingly metabolic chronic liver diseases, hepatic fibrosis (HF) has become a major challenge to global health. However, there are still no approved effective therapies for HF. Circular RNAs (circRNAs) have emerged as new potential targets of liver diseases. Thus, this research aims to clarify the role of circ_0008494 in liver fibrosis and reveal its mechanism.
Methods
circRNA profiles were screened by RNA sequencing and the location of circ_0008494 was confirmed by fluorescence in situ hybridization assay in human liver fibrosis tissues. Bioinformatics analysis was used for result prediction and dual luciferase reporter, together with AGO-RIP and biotin-coupled miRNA capture assays, were used to determine miR-185-3p/collagen type I alpha 1 chain (Col1a1) as the target of circ_0008494. A stable circ_0008494-interfering cell line of the hepatic stellate cells (HSCs) was constructed and used to determine the regulatory mechanism of circ_0008494/ miR-185-3p/ Col1a1 axis.
Results
Hsa_circ_0008494 was significantly over-expressed and uniquely located at the cytoplasm of HSCs in human HF tissues. Together, dual luciferase reporter, AGO-RIP and biotin-coupled miRNA capture assays validated that circ_0008494 acted as a sponge of miR-185-3p. Rescue assays demonstrated suppressing circ_0008494 could inhibit HSCs’ activation, proliferation, migration and promote their apoptosis through miR-185-3p. In particular, the fibrosis indicator, Col1a1, was predicted as the direct target of miR-185-3p and the suppression of circ_0008494 inhibited the expression of Col1a1 by releasing miR-185-3p.
Conclusions
Knocking down circ_0008494 ameliorated fibrosis through the miR-185-3p/Col1a1 axis. circ_0008494 could be a promising treatment target for hepatic fibrosis.
The Impact of the September 7th 2017 Earthquake on the Businesses of the Municipal Market of Juchitán De Zaragoza Due to Property Damage
Authors: Soto David Ortiz , Angulo Eduardo Reinoso , Ruiz Jorge Alberto Villalobos 
Published: March 2022

Abstract
Earthquakes of great intensity often affect businesses because the buildings where they operate are severely damaged, in this sense, the municipal market of Juchitán de Zaragoza represents an interesting case study. This investigation identifies the damage to property during the 8.2 Mw earthquake that occurred on September 7th, 2017, observing that the short column problem occurred in most of the columns, a settlement and shear failures in beams and non-structural walls, and later the structural and non-structural rehabilitation are detailed. Likewise, a statistical report is presented on a survey applied in November 2020 to 165 businesses established in the market to evaluate the business impact of the loss of the building’s operability due to the destructive event. According to the results obtained, only 4.24% of the economic units surveyed did not have direct losses due to the earthquake, on the other hand, 45.46% could not operate for more than a month and 33.94% considered that they stopped earning more than $ 3,000 MXN ( $ 160 USD) during the time of absolute stoppage of its activities.
Effect of annual hospital admissions of cardiac out-of-hospital cardiac arrest patients on prognosis following cardiac arrest
Authors: Tsuchida Takumi , Ono Kota , Maekawa Kunihiko , Hayamizu Mariko , Hayakawa Mineji 
Published: March 2022

Abstract
Background: Although the prognosis of patients treated at specialized facilities has improved, the relationship between the number of patients treated at hospitals and prognosis is controversial and lacks constancy in those with out-of-hospital cardiac arrest (OHCA). This study aimed to clarify the effect of annual hospital admissions on the prognosis of adult patients with OHCA by analyzing a large cohort.Methods: The effect of annual hospital admissions on patient prognosis was analyzed retrospectively using data from the Japanese Association for Acute Medicine OHCA registry, a nationwide multihospital prospective database. This study analyzed 3,632 of 35,754 patients hospitalized for cardiac OHCA at 86 hospitals. The hospitals were divided into tertiles based on the volume of annual admissions. The effect of hospital volume on prognosis was analyzed using logistic regression analysis with multiple imputation. Furthermore, three subgroup analyses were performed for patients with return of spontaneous circulation (ROSC) before arrival at the emergency department, patients admitted to critical care medical centers, and patients admitted to extracorporeal membrane oxygenation-capable hospitals. Results: The 30-day survival rate after admission was not correlated with hospital volume in all cardiac OHCA patients and subgroups. However, the frequency of favorable neurological outcomes in cardiac OHCA patients with ROSC before arrival at the emergency department at high-volume centers was higher than those at medium- and low-volume centers. Conclusion: Hospital volume did not significantly affect the prognosis of adult patients with cardiac OHCA. However, transport to a high-volume hospital may improve the neurological prognosis in cardiac OHCA patients with ROSC before arrival at the emergency department.