bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valuing an agricultural technology startup using real options
Authors: Wilson William W. , Vetsch Lee , Bullock David W. 
Published: May 2022

AbstractThere has been substantial growth in investments for startup firms to develop agricultural technology. Although investing in startups can produce significant returns, the risk of failure is high, and the commercial strategies are largely unknown. Traditional valuation methodologies, such as discounted cash flow (DCF) and multiples, are not well suited for startups. Real options provide a methodology to quantify the value of growth opportunities and managerial flexibility, two critical features of startups. This study develops a model that integrates decision trees and a stochastic binomial lattice to quantify the value of growth opportunities and managerial flexibility in a prerevenue AgTech startup. Utilizing a binomial lattice and decision trees allows for the quantification of private and market risk. The result is a valuation that quantifies the upside optionality that other methodologies disregard. [EconLit Citations: O32, O34, Q140, Q16, C6, G11].
Chemoenzymatic Cascades for the Enantioselective Synthesis of β‐Hydroxysulfides Bearing a Stereocentre at the C−O or C−S Bond by Ketoreductases
Authors: Zhao Fei , Lauder Kate , Liu Siyu , Finnigan James D. , Charnock Simon B. R. , Charnock Simon J. , Castagnolo Daniele 
Published: May 2022

AbstractChiral β‐hydroxysulfides are an important class of organic compounds which find broad application in organic and pharmaceutical chemistry. Herein we describe the development of novel biocatalytic and chemoenzymatic methods for the enantioselective synthesis of β‐hydroxysulfides by exploiting ketoreductase (KRED) enzymes. Four KREDs were discovered from a pool of 384 enzymes identified and isolated through a metagenomic approach. KRED311 and KRED349 catalysed the synthesis of β‐hydroxysulfides bearing a stereocentre at the C−O bond with opposite absolute configurations and excellent ee values by novel chemoenzymatic and biocatalytic‐chemical‐biocatalytic (bio‐chem‐bio) cascades starting from commercially available thiophenols/thiols and α‐haloketones/alcohols. KRED253 and KRED384 catalysed the enantioselective synthesis of β‐hydroxysulfides bearing a stereocentre at the C−S bond with opposite enantioselectivities by dynamic kinetic resolution (DKR) of racemic α‐thioaldehydes.
Regioselective Magnesiations of Fluorinated Arenes and Heteroarenes Using Magnesium‐bis‐Diisopropylamide (MBDA) in Hydrocarbons
Authors: Hess Andreas , Alandini Nurtalya , Guersoy Yusuf C. , Knochel Paul 
Published: May 2022

AbstractWe report a convenient preparation of a new and storable magnesium amide (iPr2N)2Mg (magnesium‐bis‐diisopropylamide; MBDA) which proved to be especially suitable for the non‐cryogenic magnesiation of fluoro‐substituted arenes and heteroarenes providing arylmagnesium amides (ArMgDA) orbis‐heteroaryl magnesiums (HetAr)2Mg in hydrocarbons. Further reactions with electrophiles (aldehydes, ketones, allylic bromides, aryl halides (Negishi cross‐coupling)) furnished a range of polyfunctional fluoro‐substituted unsaturated building blocks. Several postfunctionalizations were described as well as NMR‐studies confirming the dimeric structure of the base.
Characterization of four mitochondrial genomes of Crambidae (Lepidoptera, Pyraloidea) and phylogenetic implications
Authors: Wu Yupeng , Liu Xiaoran , Zhang Yulei , Fang Hui , Lu Junjiao , Wang Juping 
Published: May 2022

AbstractLoxostege turbidalis,Loxostege aeruginalis,Pyrausta despicata, andCrambus perlellusbelong to Crambidae, Pyraloidea. Their mitochondrial genomes (mitogenomes) were successfully sequenced. The mitogenomes ofL. turbidalis,L. aeruginalis,P. despicata, andC. perlellusare 15 240 bp, 15 339 bp, 15 389 bp, and 15 440 bp. The four mitogenomes all have a typical insect mitochondrial gene order, including 13 protein‐coding genes (PCGs), 22 transfer RNA (tRNA) genes, two ribosomal RNA (rRNA) genes, and one A + T rich region (control region). The PCGs are initiated by the typical ATN codons, except CGA for the cox1 gene. Most PCGs terminate with common codon TAA or TAG, the incomplete codon T is found as the stop codon for cox2, nad4, and nad5. Most tRNA genes exhibit typical cloverleaf structure, except trnS1 (AGN) lacking the dihydrouridine (DHU) arm. The secondary structure of rRNA of four mitogenomes were predicted. Poly‐T structure and micro‐satellite regions are conserved in control regions. The phylogenetic analyses based on 13 PCGs showed the relationships of subfamilies in Pyraloidea. Pyralidae, and Crambidae are monophyletic, respectively. Pyralidae comprises four subfamilies, which form the following topology with high support values: (Galleriinae + ((Pyralinae + Epipaschiinae)+ Phycitinae)). Crambidae includes seven subfamilies and is divided into two lineages. Pyraustinae and Spilomelinae are sister groups of each other, and form the “PS clade.” Other five subfamilies (Crambinae, Acentropinae, Scopariinae, Schoenobiinae, and Glaphyriinae) form the “non‐PS clade” in the Bayesian inference tree. However, Schoenobiinae is not grouped with the other four subfamilies and located at the base of Crambidae in two maximum likelihood trees.
Ugi Reaction Mediated Detergent Assembly for Membrane Protein Studies
Authors: Yang Meifang , Luo Weiling , Zhang Wei , Wang Huixia , Xue Dongxiang , Wu Yiran , Zhao Suwen , Zhao Fei , Zheng Xing , Tao Houchao 
Published: May 2022

AbstractDespite the continuous efforts, the current repertoire of detergents is still far from sufficient for the biophysics studies of membrane proteins (MPs). Toward the rapid expansion of detergent diversity, we herein report a new strategy based on Ugi reaction mediated modular assembly. Structural varieties, including hydrophobic tails and hydrophilic heads, could be conveniently introduced from the multiple reaction components. New detergents then were comprehensively evaluated in the physical properties and preliminarily screened by the thermal stabilization for a transporter MsbA and a spectrum of G protein‐coupled receptors (GPCRs). For the glucagon‐like peptide‐1 receptor (GLP‐1R), a class B GPCR, detergent M‐23‐M finally stood out in a second evaluation for the maintenance of homogeneity and was further illustrated its application in the improvement of NMR study. Besides the promising utility in the MP study, the current results exhibit intriguing structural‐physical relationship that would allow the guidance in the tuning of detergent properties in the future.
The complex search for the cause of gastroschisis
Authors: de Freitas Amanda Brasil , Francisco Rossana Pulcineli Vieira , Hoshida Mara Sandra , De Oliveira Yanca Gasparini , Kulikowski Leslie Domenici , de Lourdes Brizot Maria 
Published: May 2022

AbstractBackgroundTo reveal the complex etiology of gastroschisis through two independent cases.CasesCase 1 involves gastroschisis recurrence in a consanguineous marriage, and Case 2 concerns a fetus with gastroschisis whose mother had undergone gastroplasty. Methylation array was carried out in both cases (two fetuses with gastroschisis, their two mothers, one father from the consanguineous marriage), and in 16 controls (fetuses and their respective mothers).ConclusionThe two cases presented different noninherited methylation profiles.
Stahlfasern ersetzen Bewehrung – Fundamente aus Halbfertigteilen mit hoher Fasermenge
Authors: Look Katharina , Mark Peter 
Published: May 2022

AbstractZiel des Beitrags ist es, kreuzweise Oberflächenbewehrungen von ca. 4 bis 8 cm2/m vollständig durch Stahlfaserbeton zu ersetzen. Dies gilt für die Tragfähigkeit genauso wie für die Abschätzung der Rissbreiten. Dazu werden Halbfertigteile (HFT) mit sehr hohen Fasermengen vorgefertigt und anschließend mit Ortbeton ergänzt. Das Konzept ist für die untere Bewehrung von Fundamenten oder für Wände in Halbfertigteilbauweise geeignet. Es vereinfacht und beschleunigt den Bauablauf und reduziert erheblich die Bewehrungsarbeiten. Im Beitrag wird das Konzept an einem Einzelfundament lx × ly × h = 1,1 × 1,1 × 0,3 [m] mit einem 10 cm hohen HFT und 140 kg/m3 endverankerten hochfesten Stahlfasern umgesetzt. In zwei realmaßstäblichen Experimenten wird die Biegetragfähigkeit des Fundaments mit HFT gegenüber einem klassisch bewehrten Stahlbetonfundament als Referenz getestet. Beide waren so ausgelegt, dass die Bewehrungsmenge bei Fließen in etwa dieselbe Zugkraft aufnimmt wie der Stahlfaserbeton nach Rissbildung. Die Faserbetonlösung besitzt eine rund 14 % höhere Tragfähigkeit, eine höhere Steifigkeit nach Rissbildung, eine geringere Verformungskapazität auf dem Lastniveau der Tragfähigkeit und auf Lastniveau der Gebrauchstauglichkeit etwa gleiche Rissbreiten.
Comparison of outcomes following lobectomy, segmentectomy, and wedge resection based on pathological subtyping in patients with pN0 invasive lung adenocarcinoma ≤1 cm
Authors: Song Weijian , Hou Yucheng , Zhang Jianfeng , Zhou Qianjun 
Published: May 2022

AbstractPurposeWe sought to analyze the prognostic significance of lung adenocarcinoma classification for patients with pathological N0 (pN0) lung invasive adenocarcinomas ≤1 cm who underwent surgical resection and investigate the optimal surgical procedure according to lung adenocarcinoma classification.MethodsA total of 1409 consecutive patients with resected pN0 invasive lung adenocarcinoma ≤1 cm were retrospectively reviewed. Comprehensive histologic subtyping was determined according to IASLC/ATS/ERS lung adenocarcinoma classification. Recurrence‐free survival (RFS) and overall survival (OS) were compared between patients receiving lobectomy, segmentectomy, and wedge resection.ResultsRFS and OS favored lobectomy and segmentectomy compared with wedge resection in the entire cohort. Five‐year RFS rates were 100%, 98.2%, 97.3%, 77.8%, and 82.8% (p < 0.001) for lepidic, acinar, papillary, micropapillary, and solid predominant subtypes, while 5‐year OS rates were 100%, 98.4%, 98.1%, 88.9%, and 96.5% (p < 0.001), respectively. Multivariate analysis showed that adenocarcinoma predominant pathological subtype and CT appearance were independent prognostic factors for RFS, and surgical procedure was independent factor for both RFS and OS. Specifically, wedge resection showed worse survival compared with anatomical resection in patients with papillary, micropapillary, or solid predominant subtypes, whereas in patients with lepidic predominant and acinar predominant subtypes, wedge resection showed comparable RFS with anatomical resection.ConclusionsAnatomical resection showed better survival for patients with pN0 invasive lung adenocarcinoma ≤1 cm. For patients with invasive adenocarcinoma ≤1 cm in whom anatomical resection is not feasible, wedge resection could provide similar oncological effect when tumor is lepidic predominant or acinar predominant.
DCR‐Net: Dilated convolutional residual network for fashion image retrieval
Authors: Chen Jia , Yuan Haidongqing , Zhang Yi , He Ruhan , Liang Jinxing 
Published: May 2022

AbstractFashion image retrieval is an important branch of image retrieval technology. With the rapid development of online shopping, fashion image retrieval technology has made a breakthrough from text‐based to content‐based. But there is still not a proper deep learning method used for fashion image retrieval. This article proposes a fashion image retrieval framework based on dilated convolutional residual network which consists of two major parts, image feature extraction and feature distance measurement. For image feature extraction, we first extract the shallow features of the input image by a multi‐scale convolutional network, and then develop a novel dilated convolutional residual network to obtain the deep features of the image. Finally, the extracted features are transformed into high‐dimensional features vector by a binary retrieval vector module. For feature distance measurement, we first use PCA to reduce the dimension of the extracted high‐dimensional vectors. Then we propose a mixed distance measurement algorithm combined with cosine distance and Mahalanobis distance to calculate the spatial distance of the feature vectors for similarity ranking, which solves the problems of poor robustness in complex background fashion image retrieval and the inefficiency calculation of Mahalanobis distance. The experimental results show the superiority of our fashion image retrieval framework over existing state‐of‐the‐art methods.
Detecting color boundaries on 3D surfaces by applying edge‐detection image filters on a quad‐remeshing
Authors: Huang Yi‐Jheng 
Published: May 2022

AbstractEdge detection is a common image‐processing technique that has numerous applications. In this article, we propose an algorithm for detecting edges based on the color of a mesh surface. We name the edges thecolor boundaries. Our approach is based on the data structure of a quad mesh, which makes the data structure of 3D meshes resemble the data structure of images. As a result, image‐processing methods can be applied on the 3D meshes. In this article, six classical edge detection filters are implemented on the 3D meshes. The experimental results demonstrate that our method can identify areas of high color gradient on 3D meshes. A comparison with two other methods for detecting color boundaries on 3D meshes reveals that our method is more effective at detecting boundaries. Lastly, we propose two novel applications that utilize the information of color boundaries on a 3D mesh surface.
Consumers' trust propensity and continuous use intention toward the sharing economy: A moderated mediation model
Authors: Sun Gong , Sun Ruijie , Li Jie , Wang Wangshuai , Johnson Lester 
Published: May 2022

AbstractThis study is aiming to explore the mechanism by which consumers' trust propensity affects their continuous use intention toward the sharing economy platform. The results suggest that organizational legitimacy mediates the relationship between trust propensity and continuous use intention. Moreover, we find that perceived social impact of the sharing platform moderates the indirect effect of consumers' trust propensity on continuous use intention via organizational legitimacy. This study illustrates the roles of users' personality trait and sharing platforms' social attributes in explaining consumer behavior in sharing economy. In addition, theoretical and practical implications are offered.
Pyrimidine‐Based Fluorescent Probe for Monitoring Mitophagy via Detection of Mitochondrial pH Variation
Authors: Zhou Jia , Du Wei , Shao Tao , Li Zheng , Zhang Duoteng , Wang Lan , Fang Zhijie , Li Jie , Wu Qiong , Zhang Chengwu , Li Lin 
Published: May 2022

AbstractImpaired mitophagy hinders the clearance of damaged mitochondria, inducing pathological states. Knowledge of this phenomenon is key to diagnosing certain diseases and understanding their pathogenesis. Mitophagy involves an acidization process that could serve as an ideal detection target. In this work, we designed and synthesized a mitochondrial‐targeting fluorescence probe, Z2, for evaluating pH variation. This probe exhibited remarkable “turn‐on” fluorescence under acidic conditions. In biological applications, Z2 showed a strong, specific pH detection capacity in Parkin‐overexpressing HeLa cells during the mitophagy process. The “turn‐on” fluorescence property of Z2 was also used to detect pH variations in Caenorhabditis elegans. This probe, as a novel pH assessment tool, may facilitate further research of mitophagy‐associated pathological patterns.
Stomatological management and implant‐supported rehabilitation in a patient with recessive dystrophic epidermolysis bullosa
Authors: Mestrallet Pierre , Wardani Adnane , Evrard Laurence 
Published: May 2022

AbstractInherited epidermolysis bullosa (EB) is a disease that causes epithelium fragility due to a protein anomaly caused by a genetic mutation. Epidermolysis bullosa clinical manifestations are bullae and cutaneous‐mucosal erosions. Epidermolysis bullosa is a rare disease, with different clinical presentations depending on the type and subtype. The stomatological treatment depends on the oral manifestations and EB types. There is no high level of recommendations due to the limited cases described in the literature. We describe an implant‐supported dento‐maxillary rehabilitation of a 49‐year‐old patient suffering from a newly diagnosed hereditary recessive EB with disabling oral manifestations. In the current case, the diagnosis of recessive dystrophic epidermolysis bullosa has been confirmed, and adequate dental care was carried out taking into account the disease constraints.
Fahr syndrome discovered in adulthood revealing a rare GNAS mutation in pseudohypoparathyroidism type 1a in a Tunisian family
Authors: Debbabi Wided , Khelifi Dayssem , Kharrat Issam , Samet Slim 
Published: May 2022

AbstractPseudohypoparathyroidism (PHP) indicates a rare heterogeneous group of disorders characterized by hypocalcemia, hyperphosphatemia, increased serum concentration of parathyroid hormone (PTH), and insensitivity to the biologic activity of PTH. One of its most common types is PHP‐1a. In this report, we present a familial PHP‐1a and a novel mutation of the GNAS gene.
Synthesis of Silver Nanoparticles by Using Cassia auriculata Flower Extract and Their Photocatalytic Behavior
Authors: Prabula S. Surendradev , Hentry Conchalish , Rose B. Leema , Parvathiraja Chelliah , Mani Aravind , Wabaidur Saikh Mohammad , Eldesoky Gaber E. , Islam Mohammed Ataul 
Published: May 2022

AbstractThe present work describes the biosynthesis of silver nanoparticles (NPs) from Cassia auriculata flower extract. The existence of elemental Ag with surface plasmon resonance at 430 nm was shown by ultraviolet‐visible spectroscopy. Fourier transform infrared spectroscopy was performed to identify the effective functional groups of the flower extract. Spherical, polydisperse Ag NPs with high‐crystallinity face‐centered cubic structure were revealed by X‐ray diffraction and transmission electron microscopy. The reduction of Ag+ ions and their binding energy were characterized by X‐ray photoelectron spectroscopy. The Ag NPs degrade methylene blue dye to 70 % within 120 min. The quenching of , h+, and OH• was evaluated. These properties suggest that silver NPs have potential applications in environmental‐related areas.
Enantioseparation of basic drugs by reverse phase high‐performance liquid chromatography system using carboxymethyl‐β‐cyclodextrin as chiral mobile phase additive
Authors: Ao Qiong , Zhao Hongliang , Tong Tianzhong , Peng Yangfeng , He Zhaoyang 
Published: May 2022

AbstractA rapid and efficient method was developed for enantioseparation of basic drugs, using carboxymethyl‐β‐cyclodextrin (CM‐β‐CD) as chiral mobile phase additive, rather than involving costly chiral column in high‐performance liquid chromatography (HPLC) system. Four of the six basic drug enantiomers investigated were successfully separated. The highest resolution reaches 2.15 for threo‐(1S,2S)‐2‐amino‐l‐p‐nitrophenyl‐1,3‐propanediol. The effects of the organic modifier, pH value, concentration of chiral additive, column temperature, and flow rate of mobile phase on the enantioseparation of analytes were researched. The apparent formation constants of inclusion and the thermodynamic parameters were evaluated to explain the mechanism of chiral recognition.
Flexible 3D‐Printed Test Rig for Liquid Distribution Characterization of Laboratory‐Scale Packings
Authors: Ashour Mohamed Adel , Neukäufer Johannes , Sarajlic Nadin , Klein Harald , Rehfeldt Sebastian , Paschold Jürgen , Knösche Carsten , Grützner Thomas 
Published: May 2022

AbstractIn distillation, additive manufacturing can facilitate the design and fabrication of laboratory‐scale packed columns that overcome the existing miniaturization limits while maintaining scalability. Liquid distribution is one of the appraisal criteria for new packing structures. For this purpose, a flexible 3D‐printed laboratory test rig is presented. The setup offers a wide liquid load operation range from approx. 2.5 to 20 m3m−2h−1 for column diameters of 20–50 mm. First results regarding steady‐state development, initial liquid distribution effect and liquid load variation are shown using a 3D‐printed version of the Rombopak 9M in a 20‐mm diameter column.
Linear Stability of Pipe Poiseuille Flow at High Reynolds Number Regime
Authors: Chen Qi , Wei Dongyi , Zhang Zhifei 
Published: May 2022

AbstractIn this paper, we prove the linear stability of the pipe Poiseuille flow for general perturbations at high Reynolds number regime. This has been a long‐standing problem since the experiments of Reynolds in 1883. Our work lays a foundation for the theoretical analysis of hydrodynamic stability of pipe flow, which is one of the oldest yet unsolved problems in fundamental fluid dynamics. © 2022 Wiley Periodicals LLC.
Plasma phase transition in historical aspect and the role of bound states
Authors: Khomkin Alexander L. , Shumikhin Aleksey S. 
Published: May 2022

AbstractThis paper considers the problem of the existence of the plasma phase transition (PPT) in Coulomb systems. The main focus is on the role of the bound states. We declare that the existence of bound states and the need to consider them into account is determined largely by the methodology of the PPT search. We consider phase transitions in classical Coulomb models and hydrogen plasma and point out that electron‐ion recombination is the dominant process in numerical simulation.
Hybrid localization scheme using K‐fold optimization with machine learning in WSN
Authors: Yadav Preeti , Sharma Subhash Chandra , Rishiwal Vinay 
Published: May 2022

SummaryNode localization technology can identify and track nodes, making observing data more relevant; for example, information received at the sink node would be useless to the client if node localization data from the sensor region were not included. Localization is described as determining the location of unknown sensor nodes named destination nodes applying the recognized location of anchor nodes based on measurements such as time difference of occurrence, time of occurrence, angle of occurrence, triangulation, and maximum probability. The purpose of node localization is to assign coordinates points to all sensor nodes arbitrarily put in the monitoring region and have an unknown location. Localization of nodes is essential to account for the cause of events that help group sensor querying, routing, and network coverage. In this paper, data transmission among the nodes is done by comparing the received signal strength indicator (RSSI) value with the supervised learning value. If the RSSI value is less than the supervised learning value, the data transmission takes place; else, no transmission. This paper proposes a hybrid localization scheme that effectively uses K‐fold optimization with supervised learning and gives good results for distance error and RSSI/energy efficiency. The proposed scheme can effectively detect the optimal path for data transmission, node localization for the destination, and overall performance enhancement using threshold decision making.