bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Mulberry Leaf Powder of Varying Levels on Growth Performance, Immuno-Antioxidant Status, Meat Quality and Intestinal Health in Finishing Pigs
Authors: Ma Jiayu , Ma Hong , Liu Sujie , Wang Jian , Wang Hongliang , Zang Jianjun , Long Shenfei , Piao Xiangshu 
Published: November 2022

Background: The purpose of the research was to investigate the effect of mulberry leaf powder (MP) of varying levels on growth performance, immuno-antioxidant status, meat quality and intestinal health. A total of 120 healthy finishing pigs (Duroc × [Landrace × Yorkshire], 72.2 ± 4.8 kg) were selected for this experiment and divided into four treatments, according to randomized complete block design, with three replicates of 10 pigs each (barrow:gilt = 1:1). The dietary treatments were as follows: (1) Ctrl, corn-soybean meal basal diet; (2) MP_6: basal diet with 6% MP. (3) MP_9: basal diet with 9% MP; (4) MP_12, basal diet with 12% MP. The whole experiment lasted for 33 days. Results: Compared to the Ctrl, dietary supplementation of 9% MP had no negative effects on growth performance, antioxidative capacity, intestinal digestive enzyme activities and inflammatory factors, carcass trait, the lipid profile and amino acid of muscle or related mRNA expression. MP_6 and MP_12 showed detrimental effects on average daily gain (p < 0.05) and digestibility (p < 0.05) of dry matter, crude protein and gross energy. Furthermore, MP_9 could improve (p < 0.05) the level of serum immunoglobulin M, enhance (p < 0.05) the a*24h of meat, up-regulate (p < 0.05) the mRNA expression of occludin and Mucin-2, increase (p < 0.05) the relative abundance of Bifidobacterium and decrease (p < 0.05) the relative abundance of Campylobacter in the hindgut. Conclusion: Summarizing our study, dietary supplementation of 9% MP had no negative effects on growth performance, antioxidative capacity, intestinal digestive enzyme activities and inflammatory factors, carcass trait, the lipid profile and amino acid of muscle, or related mRNA expression. Furthermore, MP_9 could improve serum immunity, enhance meat quality, up-regulate the mRNA expression related to the mechanical and chemical barriers and enrich the beneficial microbiota of the hindgut. Hence, dietary supplementation of 9% MP in finishing pigs may be advisable.
Diversity among Lasiodiplodia Species Causing Dieback, Root Rot and Leaf Spot on Fruit Trees in Egypt, and a Description of Lasiodiplodia newvalleyensis sp. nov.
Authors: El-Ganainy Sherif Mohamed , Ismail Ahmed Mahmoud , Iqbal Zafar , Elshewy Eman Said , Alhudaib Khalid A. , Almaghasla Mustafa I. , Magistà Donato 
Published: November 2022

Lasiodiplodia (family Botryosphaeriaceae) is a widely distributed fungal genus that causes a variety of diseases in tropical and subtropical regions. During 2020–2021, a routine survey of fruit tree plants was conducted in five Egyptian Governorates, and fresh samples exhibiting dieback, decline, leaf spot and root rot symptoms were collected. Collection from eight different symptomatic leaves, twigs, branches and roots of fruit trees yielded 18 Lasiodiplodia-like isolates. The sequencing data from the internal transcribed spacer region (ITS), partial translation elongation factor 1-alpha (tef1-a) and β-tubulin (tub2) were used to infer phylogenetic relationships with known Lasiodiplodia species. Two isolates obtained from black necrotic lesions on Phoenix dactylifera leaves were identified as a putative novel species, L. newvalleyensis sp. nov., and were thus subjected to further morphological characterization. The results of isolation and molecular characterization revealed that L. theobromae (n = 9) was the most common species on Mangifera indica, Citrus reticulata, C. sinensis, Ficus carica, Prunus persica, Prunus armeniaca and Pyrus communis trees. Lasiodiplodia pseudotheobromae (n = 5) was isolated from M. indica, Prunus persica and C. sinensis. Lasiodiplodia laeliocattleyae (n = 2) was isolated from C. reticulata. Pathogenicity test results suggested that all Lasiodiplodia species were pathogenic to their hosts. The present study is considered the first to characterize and decipher the diversity of Lasiodiplodia species associated with fruit trees in Egypt, using the multi-locus ITS, tef1-a and tub2 sequence data, along with morphological and pathogenic trials. To our knowledge, this is the first report of L. newvalleyensis on Phoenix dactylifera and L. laeliocattleya on C. reticulata in Egypt and worldwide.
Educar pela pesquisa: contribuições dos projetos pedagógicos no processo ensino-aprendizagem
Authors: Mota Jordana Luzia Barbosa , Costa Arlindo 
Published: November 2022

Este artigo foi elaborado a partir da dissertação e teve por objetivo analisar em duas escolas públicas de Ensino Fundamental II do município de Itacoatiara-Amazonas de que forma os professores de diferentes disciplinas trabalham projetos de aprendizagem com seus alunos. Buscou-se identificar como são realizadas e quais as principais dificuldades encontradas por professores no desenvolvimento dos mesmos e sua relação com as metodologias ativas em sala de aula. Procurou-se também, averiguar qual a relação dos projetos com o incentivo à pesquisa escolas. Nesse sentido, a dissertação foi construída a partir de uma pesquisa qualitativa com ênfase no estudo de caso para analisar as respostas a partir de uma entrevista estruturada. Dessa forma, procurou também, levantar elementos importantes a respeito da metodologia didática envolvendo o ensino através de projetos. A fundamentação teórica permitiu constatar que o ensino através de projetos surge como uma via didática que pode reestabelecer o ambiente escolar, aproximando docentes e discentes da responsabilidade de ensinar e aprender. Assim, tal metodologia coloca o professor como coordenador das ações didáticas, oportunizando situações onde o aprendiz torna-se o responsável pela sua própria aprendizagem. Além disso, os dados obtidos pela entrevista nos levam a repensar as práticas de ensino do professor que devem estar relacionadas com o envolvimento do estudante na construção do seu próprio conhecimento, nas atividades e no planejamento daquilo que se quer ensinar. Por fim, enfatiza-se que essa metodologia alternativa de ensino (projetos de aprendizagem) é um potencial instrumento para inovar as aulas e possibilitar a interdisciplinaridade entre diferentes áreas do conhecimento, além de ser uma inovação com respaldo nas tecnologias de informação, ressaltando ainda a importância desse tipo vivência para o professor, oportunizada pela formação continuada em metodologias ativas para novos projetos balizados pelo projeto político pedagógico.
Os desafios da abordagem psicossocial no transtorno por uso de álcool: relato de caso
Authors: Brasil Henrique Amaral , De Mello Guilherme Brasil Lanza 
Published: November 2022

Introdução: O álcool é a droga mais consumida no mundo. No Brasil, estima-se que cerca de 1,5% dos indivíduos entre 12 e 65 anos preenchem critérios para o transtorno por uso de álcool. A abordagem psicossocial no abuso de álcool deve ser ofertada para todos os pacientes. Objetivo: Discorrer sobre os desafios da abordagem psicossocial no transtorno por uso de álcool, através de um relato de caso. Descrição do Caso: Paciente W.F.S., sexo masculino, 25 anos, é internado devido a transtorno por uso de álcool. É morador de rua e informa que há 5 anos faz acompanhamento irregular no CERSAM. Discussão: A reabilitação psicossocial requer que o contexto social do indivíduo seja compreendido, a fim de permitir que as intervenções sejam compatíveis com a realidade do usuário. No entanto, apesar da abordagem psicossocial se fundamentar nas particularidades do indivíduo, a típica padronização do atendimento nos serviços de saúde dificulta essa prática. Pacientes como W.F.S. configuram-se como desafios particulares à estrutura dos serviços de saúde mental atuais. Conclusão: Os serviços de saúde e de atenção à saúde mental devem se reestruturar para garantir que as particularidades de cada paciente não sejam fator determinante da falha terapêutica.
Interference of wheight loss on cardiovascular risk and type 2 Diabetes 24 months after gastric bypass – cohort retrospective
Authors: Pedron Flaviana Freitas , Moura Deise Silva de , Calcing Aline , Patias Luciana Dapieve , Alvarez Glauco da Costa , Machado Ana Cristina de Assunção , Moraes Cristina Machado Bragança de 
Published: November 2022

Background: Obesity has increased in prevalence and thus has become a public health crisis. The objective of this study was to evaluate the impact of weight loss on the resolution of type 2 diabetes mellitus and cardiovascular risk. Methods: This is a retrospective cohort and descriptive study, involved consulting a database, from March 2018 to March 2019. The subjects were female and male patients, ≥18 years, who had been submitted to bariatric surgery from March 2014 to March 2016. The following data were obtained from their charts: weight, height, age, sex, presence of associated morbidities (type 2 diabetes mellitus, cardiovascular risk), glycated hemoglobina and glucose. The data a presented as the mean and standard deviation, median and interquartile range, or count and percentage. The results were considered statistically significant if p-value ≤0.05. Results: The patients had maintained a substantial percentage of excesso wheight loss (%EWL) during the postoperative period, and the Hb1Ac, glucose, CVR, and metabolic alterations were also reduced. Six months after surgery, group 1 (<70% EWL) and group 2 (≥ 70%) showed reduced Hb1Ac and, glucose and only group 2 showed reduced CVR. From 12 to 18 months after surgery, group 1 showed reduced Hb1Ac. From 18 to 24 months after surgery, group 2 showed reduced CVR and group 1 showed reduced glucose. Conclusion: Bariatric surgery had a positive effect on %EWL and modified the metabolic profile and CVR of patients up to 24 months after gastric bypass, reducing associated comorbidities.
Estenose Mitral em pacientes com histórico de Febre Reumática
Authors: Castro Ananda Pereira , Inácio Ana Gabriela Estevão , Oliveira Igor Luiz Onofre de , Novaes Eduardo Cusatis , Bosse Layanne , Oliveira Vittoria Bethonico Foresti Roseo de , Vilela Mateus Vinicius Santa Cruz , Oliveira Vanessa Siqueira Batista de , Franco Ana Luiza de Oliveira , Reis Pedro Henrique Araújo 
Published: November 2022

INTRODUÇÃO: A febre reumática é uma das principais causas de cardiopatias adquiridas na infância e na adolescência, tendo a cardite reumática como principal complicação. O diagnóstico no Brasil é feito pelos critérios de Jones e o tratamento é individual, geralmente clínico, mas podendo ser cirúrgico. O objetivo foi explorar o diagnóstico e o tratamento da doença em questão. MÉTODOS: O trabalho foi realizado com busca em quatro bases de dados, Medical Literature Analysis and Retrievel System Online (Pubmed/Medline), na Scientific Electronic Library Online (SciELO), Literatura Latino-americana e do Caribe em ciência da Saúde (LILACS) e Biblioteca Virtual em Saúde (BVS), seguida de triagem dos artigos que são relevantes ao assunto em questão, totalizando 24 artigos para a construção desse estudo. DISCUSSÃO: A etiologia da estenose mitral de origem reumática tem início com a faringoamigdalite estreptocócica, infecção causada pelo Streptococcus pyogenes. A faringoamigdalite, se não tratada de forma adequada, pode vir a evoluir para febre reumática, e consequentemente levar ao acometimento dos tecidos cardíacos, gerando a estenose mitral. A patogênese da doença pode ser explicada devido a um mimetismo celular, os anticorpos que deveriam se ligar aos antígenos identificam estruturas no corpo do hospedeiro e deflagram a inflamação que gera a doença. Existe certa dificuldade diagnóstica por escassos dados epidemiológicos. Apesar disso, estudos laboratoriais como ecografia, eletrocardiografia, radiografia de tórax e cateterismo cardíaco são grandes aliados, sendo o ecocardiograma com Doppler o principal para confirmar a investigação. o tratamento é baseado em vários parâmetros clínicos e a terapia vai se concentrar principalmente em três fundamentos: primeiro, a prevenção da recorrência da febre reumática, segundo a melhora dos sintomas e terceiro, a redução de eventos tromboembólicos. CONCLUSÃO: Constata-se que a estenose mitral é a principal complicação da febre reumática em crianças e jovens. Porém, têm-se demonstrado certa dificuldade no rastreio e diagnóstico da doença. Por conseguinte, demonstrou-se que o uso de ecocardiografia como rastreio é aliado durante a investigação.
Regulación e innovación: efectos en la industria farmacéutica mexicana
Authors: Holguín Henry Mora , Bielous Gabriela Dutrénit , Vera-Cruz Jose Alexandre O. 
Published: November 2022

Este documento analiza el efecto de la regulación en los procesos de innovación de la industria farmacéutica. El objetivo es analizar el efecto que provoca la regulación en el desarrollo de un medicamento innovador, llevado a cabo por una empresa farmacéutica de capital mexicano. La investigación es de tipo exploratorio y el diseño utilizado es un estudio de caso. El caso es el desarrollo de un nuevo medicamento para tratar la diabetes. La información se recabó principalmente mediante entrevistas semiestructuradas a personal de la empresa, que participó en el proyecto de innovación.
Para entender el efecto de la regulación se partió del análisis de los requisitos regulatorios que tuvo que satisfacer la empresa. Se analizaron las diferentes etapas del proceso de innovación, y se encontró que la mayoría de los efectos se concentran en tres etapas: (i) la etapa donde se involucran seres humanos para el desarrollo de pruebas (etapa de ensayos clínicos), (ii) la etapa de registro sanitario, donde se verifica que el medicamento a comercializar cumple con las condiciones de seguridad, eficiencia y calidad, y (iii) la etapa de manufactura, para garantizar la idónea fabricación del medicamento según las buenas prácticas.
La normatividad generó tanto efectos positivos como negativos. Entre los efectos positivos, destacan la regulación sobre propiedad intelectual y sobre la calidad del medicamento. Los principales efectos negativos se relacionan con la implementación de la regulación, más que con las exigencias que esta impone. A lo largo del proceso de innovación la regulación generó retrasos en las actividades planeadas, lo que conllevo a sobrecostos, pérdidas de competitividad e incertidumbre sobre el retorno de la inversión.
ANALISIS KEPUTUSAN PETANI MENYIMPAN HASIL PANEN PADI DI DESA MARAS KECAMATAN AIR NIPIS KABUPATEN BENGKULU SELATAN
Authors: Elviansyah Agus , Fariadi Herri , Andriani Evi 
Published: November 2022

Sebagian besar petani padi di Desa Maras Kecamatan Air Nipis Kabupaten Bengkulu Selatan memutuskan untuk menyimpan hasil panen padinya. Petani dalam menyimpan hasil panen, tentunya mempunyai pilihan dalam mengambil keputusan menyimpan atau menjual. Keputusan petani dipengaruhi oleh sejumlah faktor tertentu. Tujuan dari penelitian ini adalah mengetahui jumlah padi yang disimpan sampai musim panen berikutnya dan menentukan faktor-faktor yang mempengaruhi keputusan petani menyimpan hasil panen padi di Desa Maras Kecamatan Air Nipis Kabupaten Bengkulu Selatan. Metode penelitian yang digunakan adalah metode deskriptif dan regresi linier berganda. Hasil penelitian menunjukkan bahwa jumlah padi yang disimpan sampai musim panen berikutnya yaitu sebesar 2.125 Kg dari total produksi yaitu sebesar 2.782 Kg atau sebesar 77%. Dari hasil perhitungan uji statistik maka dapat dilihat bahwa variabel pendidikan (X4) dan pengalaman berusahatani (X6) berpengaruh terhadap keputusan petani menyimpan hasil panen padi. Sedangkan variabel jumlah produksi (X1), luas lahan (X2), umur (X3), dan jumlah tanggungan (X5) tidak berpengaruh terhadap keputusan petani menyimpan hasil panen padi.

Kata Kunci: keputusan petani, menyimpan hasil panen, faktor-faktor yang mempengaruhi
PENGARUH SERVANT LEADERSHIP DAN BUDAYA ORGANISASI TERHADAP KINERJA KARYAWAN DI HOTEL SANTIKA BENGKULU
Authors: Arini Eti , Ramadani Melinda 
Published: November 2022

Penelitian mengetahui Pengaruh servant leadership dan budaya organisasi terhadap terhadap kinerja karyawan di hotel Santika Bengkulu, baik secara parsial maupun simultan. Ada beberapa faktor yang akan dibahas dalam penelitian ini, diantaranya servant leadership dan budaya organisasi. Obyek dalam penelitian ini adalah di hotel Santika Bengkulu yang berjumlah 56 orang. Dalam penenlitian ini penulis menggunakan metode pengumpulan data dengan cara observasi, wawancara dan kuisioner.
Ada beberapa teknik analisis data yang digunakan dalam penelitian ini, menggunakan uji instrument yakni Uji validitas, Uji reliabilitas, Uji Asumsi Klasik, koefisien determinasi, dan juga uji hipotesis. Dari hasil uji regresi linier berganda didapat persamaan regresinya yaitu sebagai berikut: Y = 8,532 – 0,005(X1)+ 0,791(X2). Sementara hasil pengujian dengan uji hipotesis yang telah dilakukan dapat diketahui bahwa variabel Servant Leadership (X1) menunjukkan thitung sebesar 0,019 (lebih rendah dari nilai t tabel, atau t hitung < 1,67 (lihat distribusi pada tabel t), dan tingkat signifikansi 0,985 (signifikan > 0.05). vaeiabel Budaya Organisasi (X2) diperoleh thitung sebesar 4,413 (lebih tinggi dari nilai t tabel, atau t hitung > 1,67 (lihat distribusi pada tabel t), dan tingkat signifikansi 0,000 (signifikan < 0.000). Sehingga dapat disimpulkan bahwa Servant Leadership dan Budaya Organisasi berpengaruh secara parsial maupun simultan terhadap kinerja karyawan di Hotel Santika Bengkulu.
PENGETAHUAN DAN SIKAP REMAJA PUTRI SMA MENGENAI PERINEAL HYGIENE DENGAN TERJADINYA KEPUTIHAN
Authors: Anggelita Baureh Maisyeliani , Kaparang Grace Fresania , Andy Shintya Lea 
Published: November 2022

Various problems such as vaginal discharge, cervical cancer, skin irritation, genitals, allergies, inflammation or urinary tract infections may arise if poor maintenance over the cleanliness of the reproductive organs. Therefore, it is essential to have good knowledge and attitude regarding perineal hygiene to achieve reproductive health for adolescents. This study is to find out the relationship of knowledge and perineal hygiene attitudes, and the incidence of female adolescent vaginal discharge and whether there is a relationship between knowledge and perineal attitudes of adolescent hygiene towards the occurrence of vaginal discharge at U High School in Airmadidi. This study is a correlation study with consecutive sampling techniques. The results showed that of the 57 participants, 87.7% had received information about perineal hygiene and 50.9% got information from the internet. It was also found that 71.9% of students were at low knowledge levels but 82.5% had a good attitude, while the incidence of vaginal discharge was found at 96.5%. The spearman test found that there was a relationship of perineal hygiene knowledge with the incidence of vaginal discharge with p = 0.039<.05 with a value of r = 0.274 (weak positive strength), and there was no relationship between perineal hygiene attitude and the occurrence of vaginal discharge where p = 0.142 > 0.05. Recommendations for the next study to include other variables. For the school, to facilitate information in order to increase students' knowledge about perineal hygiene and the dangers of vaginal discharge if not handled properly.
Penerapan Prinsip Komunikasi Qaulan Sadida Dalam Dakwah Ustadz Adi Hidayat Di Channel Youtube Adi Hidayat Official
Authors: Nazar Nazar , Qoulan Sadida  
Published: November 2022

Perkembangan media digital pada saat ini tentu dapat digunakan sebagai media dalam berdakwah untuk memperluas cakrawala dakwah. Kegiatan dakwah pada saat ini sangatlah berkembang hingga dapat memanfaatkan media sosial seperti youtube. Da’i yang memanfaatkan youtube sebagai media dakwah salah satunya adalah Ustadz Adi Hidayat yang memiliki kanal resmi bernama Adi Hidayat Official dengan tim khusus yang mengelola akun tersebut. Qaulan sadida (Q.S. [4] : 9) memiliki arti perkataan yang benar, tegas, jujur, lurus, dan tidak berbelit belit. Adapun pada penelitian ini, kata Qaulan sadida memiliki 4 tanda yaitu perkataan yang benar, tegas, jujur dan tidak berbelit belit. Ini menjadi ukuran bahwa prinsip komunikasi ini diterapkan atau tidak oleh Ustadz Adi Hidayat dalam dakwahnya melalui youtube.
Penelitian ini merupakan jenis penelitian kualitatif dengan analisis isi secara deskriptif. Teori analisis isi yang digunakan pada penelitian ini adalah teori analisis isi menurut Holsti yang menyatakan bahwa kajian isi adalah teknik apapun yang digunakan untuk menarik kesimpulan melalui usaha mengidentifikasi karakteristik pesan yang dilakukan secara objektif dan sistematis. Teknik pengumpulan data pada penelitian ini yaitu observasi dan dokumentasi. Sumber data dalam penelitian ini terdiri dari data primer dan data sekunder. Data primer dari penelitian ini berupa tayangan video dakwah yang disampaikan oleh Ustadz Adi Hidayat dalam Channel youtube Adi Hidayat Official dengan judul yaitu khusyuk dalam sholat, 5 manfaat sholat bagi kehidupan, dan bahagia dalam naungan Al Qur’an dan As Sunnah. Adapun data sekunder diperoleh dari aneka jenis karya tulis baik buku, jurnal, hingga artikel pemberitaan Adi Hidayat yang dapat menunjang penelitian ini. Berdasarkan dari hasil penelitian menunjukkan bahwa Ustadz Adi Hidayat menerapkan prinsip komunikasi qaulan sadida berdasarkan 4 tanda yaitu perkataan yang benar, perkataan yang tegas, perkataan yang jujur dan tidak berbelit belit.