bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drift diffusion equations with fractional diffusion on compact Lie groups
Authors: Cardona Duván , Delgado Julio , Ruzhansky Michael 
Published: October 2022

AbstractIn this work we investigate the well-posed for diffusion equations associated to subelliptic pseudo-differential operators on compact Lie groups. The diffusion by strongly elliptic operators is considered as a special case and in particular the fractional diffusion with respect to the Laplacian. The general case is studied within the Hörmander classes associated to a sub-Riemannian structure on the group (encoded by a Hörmander system of vector fields). Applications to diffusion equations for fractional sub-Laplacians, fractional powers of more general subelliptic operators and the corresponding quasi-geostrophic model with drift D are investigated. Examples on $$\text {SU}(2)$$

SU
(
2
)

for diffusion problems with fractional diffusion are analysed.
Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women
Authors: Mutie Pascal M. , Pomares-Millan Hugo , Atabaki-Pasdar Naeimeh , Coral Daniel , Fitipaldi Hugo , Tsereteli Neli , Tajes Juan Fernandez , Franks Paul W. , Giordano Giuseppe N. 
Published: October 2022

Abstract
Aims/hypothesis
Excess adiposity is differentially associated with increased risk of cardiometabolic disease in men and women, according to observational studies. Causal inference studies largely assume a linear relationship between BMI and cardiometabolic outcomes, which may not be the case. In this study, we investigated the shapes of the causal relationships between BMI and cardiometabolic diseases and risk factors. We further investigated sex differences within the causal framework.

Methods
To assess causal relationships between BMI and the outcomes, we used two-stage least-squares Mendelian randomisation (MR), with a polygenic risk score for BMI as the instrumental variable. To elucidate the shapes of the causal relationships, we used a non-linear MR fractional polynomial method, and used piecewise MR to investigate threshold relationships and confirm the shapes.

Results
BMI was associated with type 2 diabetes (OR 3.10; 95% CI 2.73, 3.53), hypertension (OR 1.53; 95% CI 1.44, 1.62) and coronary artery disease (OR 1.20; 95% CI 1.08, 1.33), but not chronic kidney disease (OR 1.08; 95% CI 0.67, 1.72) or stroke (OR 1.08; 95% CI 0.92, 1.28). For cardiometabolic risk factors, BMI was positively associated with glucose, HbA1c, triacylglycerol levels and both systolic and diastolic BP. BMI had an inverse causal relationship with total cholesterol, LDL-cholesterol and HDL-cholesterol. The data suggest a non-linear causal relationship between BMI and blood glucose levels, HbA1c and lipid fractions (p<0.001), more strongly in men than women. The piecewise MR results were consistent with the fractional polynomial results. The causal effect of BMI on coronary artery disease, total cholesterol and LDL-cholesterol was different in men and women, but this sex difference was only significant for LDL-cholesterol after controlling for multiple testing (p<0.001). Further, the causal effect of BMI on coronary artery disease varied by menopause status in women.

Conclusions/interpretation
We describe the shapes of causal effects of BMI on cardiometabolic diseases and risk factors, and report sex differences in the causal effects of BMI on LDL-cholesterol. We found evidence of non-linearity in the causal effect of BMI on diseases and risk factor biomarkers. Reducing excess adiposity is highly beneficial for health, but there is greater need to consider biological sex in the management of adiposity.

Graphical abstract
Documenting occupational sorting by gender in the UK across three cohorts: does a grand convergence rely on societal movements?
Authors: Lekfuangfu Warn N. , Lordan Grace 
Published: October 2022

AbstractWe consider the extent to which temporal shifts have been responsible for an increased tendency for females to sort into traditionally male roles over time, versus childhood factors. Drawing on three cohort studies, which follow individuals born in the UK in 1958, 1970 and 2000, we compare the shift in the tendency of females in these cohorts to sort into traditionally male roles compared to males, to the combined effect of a large set of childhood variables. For all three cohorts, we find strong evidence of sorting along gendered lines, which has decreased over time, yet there is no erosion of the gender gap in the tendency to sort into occupations with the highest share of males. Within the cohort, we find little evidence that childhood variables change the tendency for females of either the average or highest ability to sort substantively differently. Our work is highly suggestive that temporal shifts are what matter in determining the differential gendered sorting patterns we have seen over the last number of decades, and also those that remain today. These temporal changes include attitudinal changes, technology advances, policy changes and economic shifts.
An inhibitor of BRD4, GNE987, inhibits the growth of glioblastoma cells by targeting C-Myc and S100A16
Authors: Ma Liya , Li Gen , Yang Tianquan , Zhang Li , Wang Xinxin , Xu Xiaowen , Ni Hong 
Published: October 2022

Abstract
Purpose
Among children, glioblastomas (GBMs) are a relatively common type of brain tumor. BRD4 expression was elevated in GBM and negatively correlated with the prognosis of glioma. We investigated the anti-GBM effects of a novel BRD4 inhibitor GNE987.

Methods
We evaluated the anti-tumor effect of GNE987 in vitro and in vivo by Western blot, CCK8, flow cytometry detection, clone formation, the size of xenografts, and Ki67 immunohistochemical staining, and combined ChIP-seq with RNA-seq techniques to find its anti-tumor mechanism.

Results
In vitro experiments showed that GNE987 significantly degraded BRD4, inhibited the proliferation of GBM cells, blocked the cell cycle, and induced apoptosis. Similarly, in vivo experiments, GNE987 also inhibited GBM growth as seen from the size of xenografts and Ki67 immunohistochemical staining. Based on Western blotting, GNE987 can significantly reduce the protein level of C-Myc; meanwhile, we combined ChIP-seq with RNA-seq techniques to confirm that GNE987 downregulated the transcription of S100A16 by disturbing H3K27Ac. Furthermore, we validated that S100A16 is indispensable in GBM growth.

Conclusion
GNE987 may be effective against GBM that targets C-Myc expression and influences S100A16 transcription through downregulation of BRD4.
An Almost Optimal Bound on the Number of Intersections of Two Simple Polygons
Authors: Ackerman Eyal , Keszegh Balázs , Rote Günter 
Published: October 2022

AbstractWhat is the maximum number of intersections of the boundaries of a simple m-gon and a simple n-gon? This is a basic question in combinatorial geometry, and the answer is easy if at least one of m and n is even: If both m and n are even, then every pair of sides may cross and so the answer is mn. If exactly one polygon, say the n-gon, has an odd number of sides, it can intersect each side of the m-gon polygon at most $$n-1$$

n
-
1

times; hence there are at most $$mn-m$$

m
n
-
m

intersections. It is not hard to construct examples that meet these bounds. If both m and n are odd, the best known construction has $$mn-(m+n)+3$$

m
n
-
(
m
+
n
)
+
3

intersections, and it is conjectured that this is the maximum. However, the best known upper bound is only $$mn-(m + \lceil {n}/{6} \rceil )$$

m
n
-
(
m
+
⌈
n
/
6
⌉
)

, for $$m \ge n$$

m
≥
n

. We prove a new upper bound of $$mn-(m+n)+C$$

m
n
-
(
m
+
n
)
+
C

for some constant C, which is optimal apart from the value of C.
What Does It Mean to Be Responsive to a Partner’s Sexual Needs? Toward a Definition of Sexual Need Responsiveness
Authors: Vowels Laura M. , Roos Carla A. , Mehulić Jasmina , O’Dean Siobhan M. , Sánchez-Hernández M. Dolores 
Published: October 2022

AbstractBeing responsive to a partner’s sexual needs in relationships (i.e., sexual need responsiveness) is associated with higher sexual and relationship satisfaction. Previous research has focused on researcher-led definitions of sexual need responsiveness. The purpose of the present study was to develop a participant-informed definition of sexual need responsiveness. A total of 305 individuals responded to five open-ended questions concerning the definition and behaviors pertaining to sexual need responsiveness. The content analysis results showed that the most common elements in participants’ definition included listening to and accommodating each other's sexual needs and wishes whenever possible, while respecting both partners’ safety and boundaries. Both verbal and non-verbal communication in various forms was used to express and share needs with partners and participants often evaluated responsiveness in terms of their sexual satisfaction. The results provide a participant-informed definition of sexual need responsiveness and can be used to inform research and clinical practice.
Government effectiveness and inequality in Italian regions
Authors: Barra Cristian , Papaccio Anna , Ruggiero Nazzareno 
Published: October 2022

AbstractUsing regional data for Italy over the 2004–2019 period, this paper investigates the relationship between government effectiveness and inequality. For our empirical purposes, ordinary least squares, instrumental variable (IV) and generalized methods of moments regressions have been employed. Our evidence indicates that improved government effectiveness has some role in reducing inequality in the most developed regions of the North, but has no effect in both the Centre and in the peripheral Southern regions.
Getting real about pretense
Authors: Hutto Daniel 
Published: October 2022

AbstractThis paper argues that radical enactivism (RE) offers a framework with the required nuance needed for understanding of the full range of the various forms of pretense. In particular, its multi-storey account of cognition, which holds that psychological attitudes can be both contentless and contentful, enables it to appropriately account for both the most basic and most advanced varieties of pretense. By comparison with other existing accounts of pretense, RE is shown to avoid the pitfalls of representationalist theories while also allowing us to combine the best elements of the praxeological enactivist (Weichold & Rucińska, 2021) and Langland-Hassan’s (2020, 2021) proposals about pretense, while avoiding their key shortcomings.
An analysis of energy efficiency of the Pearl River Delta of China based on super-efficiency SBM model and Malmquist index
Authors: Liu Boyu 
Published: October 2022

AbstractWith the rapid growth rate of China’s economy, the extensive pattern of economic growth of “high energy consumption and low output” has magnified the constraints of energy issues on China’s economic development and environmental protection, which highlights the importance of improving energy efficiency. As one of the three major economic zones in China, the Pearl River Delta region also faces high energy consumption and pollution emissions while developing at a high speed. Hence, improving the energy efficiency of the Pearl River Delta region is needed, as it not only is conducive to driving its development of the surrounding green economy, but also promotes the subsequent sustainable economic development. However, there are few literatures on the calculation and analysis of energy efficiency in the Pearl River Delta, and lacking a systematic analysis of input–output index system of energy efficiency measurement. Therefore, this paper calculates the energy efficiencies and the Malmquist indexes based on the panel data of the nine cities in the Pearl River Delta from 2005 to 2019 through super-efficiency SBM model and Malmquist index method by using MAXDEA and MATLAB software. The result illustrates that all regions in the Pearl River Delta except Guangzhou and Shenzhen show obvious energy inefficiency, which is mainly caused by the imbalance between technical efficiency and scale efficiency. Based on the calculation results, this paper gives some relevant suggestions for the further approach of energy reform in the Pearl River Delta according to the calculation results.
Blended-eLearning Impact on Health Worker Stigma Toward Alcohol, Tobacco, and Other Psychoactive Substance Users
Authors: Clair Veronic , Rossa-Roccor Verena , Mutiso Victoria , Rieder Sasha , Musau Abednego , Frank Erica , Ndetei David 
Published: October 2022

AbstractThis study evaluated factors affecting the completion of blended-eLearning courses for health workers and their effect on stigma. The two courses covered the screening and management of harmful alcohol, tobacco, and other substance consumption in a lower-middle-income country setting. The courses included reading, self-reflection exercises, and skills practice on communication and stigma. The Anti-Stigma Intervention-Stigma Evaluation Survey was modified to measure stigma related to alcohol, tobacco, or other substances. Changes in stigma score pre- and post-training period were assessed using pairedt-tests. Of the 123 health workers who registered, 99 completed the pre- and post-training surveys, including 56 who completed the course and 43 who did not. Stigma levels decreased significantly after the training period, especially for those who completed the courses. These findings indicate that blended-eLearning courses can contribute to stigma reduction and are an effective way to deliver continuing education, including in a lower-middle-income country setting.
The Effect of Systemic Racism and Homophobia on Police Enforcement and Sexual and Emotional Violence among Sex Workers in East London: Findings from a Cohort Study
Authors: Platt Lucy , Bowen Raven , Grenfell Pippa , Stuart Rachel , Sarker M. D. , Hill Kathleen , Walker Josephine , Javarez Xavier , Henham Carolyn , Mtetwa Sibongile , Hargreaves James , Boily M.-C. , Vickerman Peter , Hernandez Paz , Elmes Jocelyn 
Published: October 2022

Abstract
There is extensive qualitative evidence of violence and enforcement impacting sex workers who are ethnically or racially minoritized, and gender or sexual minority sex workers, but there is little quantitative evidence. Baseline and follow-up data were collected among 288 sex workers of diverse genders (cis/transgender women and men and non-binary people) in London (2018–2019). Interviewer-administered and self-completed questionnaires included reports of rape, emotional violence, and (un)lawful police encounters. We used generalized estimating equation models (Stata vs 16.1) to measure associations between (i) ethnic/racial identity (Black, Asian, mixed or multiple vs White) and recent (6 months) or past police enforcement and (ii) ethnic/racial and sexual identity (lesbian, gay or bisexual (LGB) vs. heterosexual) with recent rape and emotional violence (there was insufficient data to examine  the association with transgender/non-binary identities). Ethnically/racially minoritized sex workers (26.4%) reported more police encounters partly due to increased representation in street settings (51.4% vs 30.7% off-street, p = 0.002). After accounting for street setting, ethnically/racially minoritized sex workers had higher odds of recent arrest (adjusted odds ratio 2.8, 95% CI 1.3–5.8), past imprisonment (aOR 2.3, 95% CI 1.1–5.0), police extortion (aOR 3.3, 95% CI 1.4–7.8), and rape (aOR 3.6, 95% CI 1.1–11.5). LGB-identifying sex workers (55.4%) were more vulnerable to rape (aOR 2.4, 95% CI 1.1–5.2) and emotional violence. Sex workers identifying as ethnically/racially minoritized (aOR 2.1, 95% CI 1.0–4.5), LGB (aOR 2.0, 95% CI 1.0–4.0), or who use drugs (aOR 2.0, 95% CI 1.1–3.8) were more likely to have experienced emotional violence than white-identifying, heterosexual or those who did not use drugs. Experience of any recent police enforcement was associated with increased odds of rape (aOR 3.6, 95% CI 1.3–8.4) and emotional violence (aOR 4.9, 95% CI 1.8–13.0). Findings show how police enforcement disproportionately targets ethnically/racially minoritized sex workers and contributes to increased risk of rape and emotional violence, which is elevated among sexual and ethnically/racially minoritized workers.
Flexibility for intergenerational justice in climate resilience decision-making: an application on sea-level rise in the Netherlands
Authors: Teodoro Jose D. , Doorn N. , Kwakkel J. , Comes T. 
Published: October 2022

AbstractTo adapt to a changing climate, decision-makers design, evaluate, and implement measures that have an implication of justice on citizens in the present and well into the future. Decision-makers are often required to make decisions without certainty of the consequences and understanding their effects on intergenerational justice. Thus, managing the impacts of climate change requires novel decision-aiding approaches that consider climate impacts’ temporal and spatial heterogeneity and the uncertainty in climate predictions, preferences, and values. We reviewed the literature on the extent to which principles of intergenerational justice—conservation of options and resources for future generations—have been integrated to traditional approaches in climate resilience decision-making. We explore the extent to which flexibility, i.e., the conservation and expansion of options in subsequent decision periods, can contribute to upholding the principles of intergenerational justice under uncertainty. We illustrate the approach in the case of the Delta Programme in the Netherlands, a complex system designed to protect against sea-level rise (SLR). Designing adaptation strategies to SLR with flexibility as a core concept brings significant advantages in circumstances of uncertainty. The conservation of options in flexible pathways, in this case, contributes to the principles of intergenerational justice. Our civilization’s long-term sustainability and survival may depend on the extent to which individuals can see beyond their gains and toward the gains of the collective society at an intergenerational scale.
Critical HR capabilities in agile organisations a cross-case analysis in swiss SMEs
Authors: Mollet Léonie S. , Kaudela-Baum Stephanie 
Published: October 2022

AbstractThe current agile management literature is missing insight about the challenges agile organisations face regarding human resource management (HRM/HR) – and how they may overcome them. Based on an exploratory case study design, we investigate the managerial challenges in seven pioneering companies, all of them medium-sized firms (SME) from the IT sector in Switzerland. The majority of the qualitative data gathered stems from interviews, that was coded along emerging themes. The results are divided into three sections: a proposed (1) typology for Business Agilists, (2) general challenges and (3) emergent agile HR capabilities. Following the proposition of agile HR as a distributed capability, we discuss several theoretical and practical implications. In essence, particular attention is to be placed on a cultural fit between employees and the agile working environment, which demands individuals to be highly self-reliant and autonomous. This entails the need for a flexible support structure to grow employees’ skills accordingly. The conclusion emphasises addressing the shared responsibility for HR work and the corresponding broad capability development of different role holders, resulting in the suggestion to replace the term HR with people management as a more inclusive bracket for integrative HR, culture and leadership work in agile organisations.
Soziale Arbeit im Kontext End-of-Life Care
Authors: Schütte-Bäumner Christian , Klomann Verena 
Published: October 2022

ZusammenfassungDer Beitrag arbeitet das Potenzial der Sozialen Arbeit im Kontext End-of-Life Care und für die Begleitung in der letzten Lebensphase heraus, identifiziert charakteristische Herausforderungen und zeigt die Notwendigkeit einer professionstheoretischen Fundierung und Verortung für diesen Handlungsbereich auf. Er führt zudem in den Schwerpunkt ein.
Multi-isotopic study of the earliest mediaeval inhabitants of Santiago de Compostela (Galicia, Spain)
Authors: Pérez-Ramallo Patxi , Grandal-d´Anglade Aurora , Organista Elia , Santos Elena , Chivall David , Rodríguez-Varela Ricardo , Götherström Anders , Etxeberria Francisco , Ilgner Jana , Fernandes Ricardo , Arsuaga Juan Luis , Le Roux Petrus , Higham Tom , Beaumont Julia , Koon Hannah , Roberts Patrick 
Published: October 2022

AbstractSantiago de Compostela is, together with Rome and Jerusalem, one of the three main pilgrimage and religious centres for Catholicism. The belief that the remains of St James the Great, one of the twelve apostles of Jesus Christ, is buried there has stimulated, since their reported discovery in the 9th century AD, a significant flow of people from across the European continent and beyond. Little is known about the practical experiences of people living within the city during its rise to prominence, however. Here, for the first time, we combine multi-isotope analysis (δ13C, δ15N, δ18Oap, δ13Capand87Sr/86Sr) and radiocarbon dating (14C) of human remains discovered at the crypt of the Cathedral of Santiago to directly study changes in diet and mobility during the first three centuries of Santiago’s emergence as an urban centre (9th–12th centuries AD). Together with assessment of the existing archaeological data, our radiocarbon chronology broadly confirms historical tradition regarding the first occupation of the site. Isotopic analyses reveal that the foundation of the religious site attracted migrants from the wider region of the northwest corner of the Iberian Peninsula, and possibly from further afield. Stable isotope analysis of collagen, together with information on tomb typology and location, indicates that the inhabitants of the city experienced increasing socioeconomic diversity as it became wealthier as the hub of a wide network of pilgrimage. Our research represents the potential of multidisciplinary analyses to reveal insights into the origins and impacts of the emergence of early pilgrimage centres on the diets and status of communities within Christian mediaeval Europe and beyond.
Semiresorbable biologic hybrid meshes for ventral abdominal hernia repair in potentially contaminated settings: lower risk of recurrence
Authors: Goetz Markus , Jurczyk Maria , Junger Henrik , Schlitt Hans J. , Brunner Stefan M. , Brennfleck Frank W. 
Published: October 2022

AbstractIn case of potential contamination, implantation of synthetic meshes in hernia and abdominal wall surgery is problematic due to a higher risk of mesh infection. As an alternative, a variety of different biologic meshes have been used. However, relevant data comparing outcome after implantation of these meshes are lacking. Between January 2012 and October 2021, biologic meshes were used for reconstruction of the abdominal wall in 71 patients with preoperative or intraoperative abdominal contamination. In this retrospective study, semiresorbable biologic hybrid meshes (BHM) and completely resorbable meshes (CRM) were compared and analyzed using a Castor EDC database. In 28 patients, semiresorbable biologic hybrid meshes were used; in 43 patients, completely resorbable meshes were used. Both groups showed no difference in age, gender, BMI, operation duration, hernia size and Charlson comorbidity index. The risk degree of surgical-site occurrences was graded according to the Ventral Hernia Working Group (VHWG) classification, and the median value was 3 (range 2–4) in the BHM group and 3 (range 2–4) in the CRM group. Hernia recurrence within 24 months after hernia repair was significantly lower in the BHM group (3.6% vs. 28.9%; p = 0.03), while postoperative complication rate, with respect to seromas in need of therapy (61.4% vs. 55.5%, p = 0.43) and operative revision (28.6% vs. 16.3%, p = 0.22) was not different in either group. Biologic hybrid meshes can be used safely in case of possible contamination. BHM seems to reduce the risk of hernia recurrence compared to completely resorbable biologic meshes, but this has to be investigated further.