bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoadjuvant ceritinib treatment in ALK‐rearranged locally advanced adenosquamous carcinoma: A case report
Authors: Mai Shixiong , Wang Yue , Wang Xuemei , Yang Wei , Gao Haicheng , Xu Zhenan , Xu Lei , Xu Li , Ou Qiuxiang , Chen Hanlin , Wang Zhenxing 
Published: July 2022

AbstractHere, we first report a case of neoadjuvant ceritinib for locally advanced lung adenosquamous carcinoma. In this study, a locally advanced adenosquamous carcinoma (ASC) patient with EML4‐ALK fusion who achieved a partial response with neoadjuvant ceritinib treatment after a cycle of neoadjuvant chemotherapy did not show significant efficacy. A complete surgical resection was performed with mild adhesions and a small amount of bleeding intraoperatively. The EML4‐ALK fusion was detected by targeted next‐generation sequencing (NGS) in both pretreatment biopsy and the postoperative tissue specimens with a dramatic decrease in the allele frequency (26.2% [pre]–2.3% [post]). Pathological examination of the postoperative specimens indicated a diagnosis of ASC but the proportions of adenocarcinoma and squamous cell carcinoma cells in the primary lung tumor and metastatic lymph node site were different, suggesting the various responses to ceritinib. Thus, with the case presented here, we provide the clinical evidence for ALK‐positive locally advanced ASC patients benefiting from neoadjuvant ceritinib treatment with a tolerable safety profile, whereas further cohort studies of the efficacy and safety of neoadjuvant ceritinib in such patients are needed.
Age structure dynamics in an eastern collared lizard population from founding to demographic stability
Authors: Templeton A. R. , Neuwald J. L. , Conley A. K. 
Published: July 2022

AbstractThe global decline of reptile species has raised much concern, and many translocation programs have been implemented in response to this decline. Most of these programs have not been successful, but one exception is the translocation program for eastern collared lizards (Crotophytus collaris collaris) that had experienced massive local extinction on glades in the Ozarks in central North America. Translocation coupled with glade restoration was initiated in the 1980s, including reintroductions starting in 1984 on Stegall Mountain in southern Missouri. The translocated populations underwent three distinct demographic phases: (1) an isolate phase with no net growth in population size, no colonization of nearby glades and almost no dispersal among populations, (2) a colonizing phase of high dispersal, colonization of new glades and population growth that started with the onset of prescribed woodland burning and (3) a stable metapopulation phase established by 2000 on Stegall Mountain in which the number of occupied glades, total population size and measures of genetic variation were roughly constant. This study uses distinct color phases to infer the age of 1162 marked individuals. Age probabilities were assigned to 391 individuals based on time‐of‐capture within the field season and snout‐vent length, as calibrated from following 529 individuals first captured as hatchlings. Age structure differed significantly between phases. The isolate phase was characterized by an old age structure. The colonization phase had a younger age structure and much more recruitment. The stable metapopulation phase had an intermediate age structure. These dynamic age structure attributes show that species cannot be regarded as static units, and ignoring this dynamism can result in poor conservation practice. These results also validate age‐structure as a monitoring device for a conservation program and a tool to identify significant shifts in the environment or management that have a conservation impact, in this case prescribed woodland burning.
Morphological variations in the transverse foramen of the axis in Japanese serows (Capricornis crispus)
Authors: Onouchi Sawa , Yoshida Tomoki , Mori Takashi , Saito Shouichiro , Atoji Yasuro 
Published: July 2022

AbstractThe presence of transverse foramina in the axes of Japanese serows, a special national natural treasure in Japan, has been reported to be unstable, but other variations are unknown. In this study, we analysed the shape, cross‐sectional area, length, and volume of the transverse foramen in the axes of 19 specimens using gross anatomy and computed tomography (CT) scan. There were four types in the transverse foramen: type 1, having the transverse foramina; type 2, having two cranial openings; type 3, sifting a caudal opening to the ventral side of the transverse process; and type 4, having no transverse foramina. Although the transverse foramina showed different types on the left and right sides in several specimens, there were no statistically significant differences in the length and volume. This variation may be related to running patterns of the vertebral artery penetrating the transverse foramina. Two goats without the transverse foramina were examined to infer a running pattern of the vertebral artery instead of Japanese serows. The vertebral artery in the goats branched in two directions (spinal and muscle), between the axis and the third cervical vertebra. This passage of the goat vertebral artery might be presumed in type 4 of Japanese serows. This study reveals the instability of the transverse foramina in the axes of Japanese serows and provides new data to compare the axes of other ruminants.
R0 resection of vaginal stump recurrence of gynecologic malignancy by bi‐directional endoscopic approach: A case series of four patients
Authors: Yokoe Takuya , Kita Masato , Butsuhara Yusuke , Hisamatsu Yoji , Okada Hidetaka 
Published: July 2022

AbstractVaginal stump recurrence post‐hysterectomy for gynecologic malignancies occurs in 2%–3% of cases. Local excision has been recognized as the primary treatment of localized recurrence, in which precise surgical margin is critical. However, R0 resection is not always easy, given the deep and narrow operation field, as well as severe postoperative fibrosis or adhesion of the vaginal stump at times. Here, we report four cases of vaginal stump recurrence of gynecologic malignancies resected by bi‐directional (laparoscopic and pneumovaginoscopic) endoscopy to overcome these difficulties. The primary tumors were uterine cancer in two cases and uterine cervical and ovarian cancer in one case each. The mean operating time was 199 (162–235) minutes, blood loss was minimal, and no perioperative complications were observed. Postoperative follow‐up (7.0–19.4 months) revealed no recurrence. This combined procedure could be a therapeutic option for localized vaginal stump recurrence.
Justifying ethical values: A purposive ethics for managers
Authors: Spillane Robert , Joullié Jean‐Etienne 
Published: July 2022

AbstractThis essay addresses the question of how managers justify ethical values. Traditionally, ethical values have been justified by appeals to intuition expressed injunctively and judged to be obligatory. This tradition has led to ethical relativism and a widespread scepticism about the possibility of basing ethics on reasoning. There are, however, alternative strategies for ethical justification in which conclusions are derived deductively from purposive propositions. This essay revisits the notion of reason, purpose and ethical justification in management to outline a purposive ethics for managers. The implications for management practice and relevance for management researchers of such an ethics are presented and defended.
Predictors of early mortality in multiple myeloma: Results from the Australian and New Zealand Myeloma and Related Diseases Registry (MRDR)
Authors: McQuilten Zoe , Wellard Cameron , Moore Elizabeth , Augustson Bradley , Bergin Krystal , Blacklock Hilary , Harrison Simon , Ho P. Joy , King Tracy , Quach Hang , Mollee Peter , Rosengarten Brian , Walker Patricia , Wood Erica , Spencer Andrew ,   Australian and New Zealand Myeloma and Related Diseases Registry
Published: July 2022

SummaryThe frequency and causes of early mortality in patients with newly diagnosed multiple myeloma (NDMM) have not been well described in the era of novel agents. We investigated early mortality in a prospective cohort study of all patients with NDMM registered on the Australian and New Zealand Myeloma and Related Diseases Registry (MRDR) at 36 institutions between July 2011 and March 2020. Early mortality was defined as death from any cause within the first 12 months after diagnosis. A total of 2377 patients with NDMM were included in the analysis, with a median (interquartile range) age of 67.4 (58.9–74.60 years, and 60% were male. Overall, 216 (9.1%) patients died within 12 months, with 119 (4.5%) having died within 6 months. Variables that were independent predictors of early mortality after adjustment in multivariable regression included age (odds ratio [OR] 1.07, 95% confidence interval [CI] 1.05–1.08; p < 0.001), Eastern Cooperative Oncology Group performance status (OR 1.50, 95% CI 1.26–1.79; p < 0.001), serum albumin (OR 0.95, 95% CI 0.93–0.98; p < 0.001), cardiac disease (OR 1.96, 95% CI 1.35–2.86; p < 0.001) and International Staging System (OR 1.40, 95% CI 1.07–1.82; p = 0.01). For those with a primary cause of death available, it was reported as disease‐related in 151 (78%), infection 13 (7%), other 29 (15%). Infection was listed as a contributing factor for death in 38% of patients.
How collective bargaining shapes poverty: New evidence for developed countries
Authors: Pineda‐Hernández Kevin , Rycx François , Volral Mélanie 
Published: July 2022

AbstractAlthough many studies point to the significant influence of collective bargaining (CB) institutions on earnings inequalities, evidence on how these institutions shape poverty rates across developed economies remains surprisingly scarce. This paper explicitly addresses the relationship between CB systems and working‐age poverty ratesbeforeandaftertaxes and transfers in 24 developed countries over the period 1990–2015. Our results show that countries with a more centralized CB system, a more extended bargaining coverage rate and/or a higher trade union density display significantly lower poverty rates. However, these results only hold in a post‐tax benefit scenario. Controlling for country and time fixed effects and a wide range of covariates, our estimates indeed suggest that the poverty‐reducing effect of CB institutions stems from the political strength of trade unions in promoting public social spending rather than from any direct effect on earnings inequalities. Sensitivity tests for endogeneity and overlapping samples support this conclusion.
Validation of the Italian version of the Tool to Measure Parenting Self‐Efficacy questionnaire using data from an intervention study
Authors: Roncaglia Francesca , Bonvicini Laura , Kendall Sally , Panza Costantino , Ferraroni Monica , Giorgi Rossi Paolo 
Published: July 2022

AbstractBackgroundParent self‐efficacy (PSE), parents' confidence in their ability to successfully raise their children, has proved to be a powerful direct predictor of specific positive parenting practices. The aim of this study was to validate the Italian version of the Tool to Measure Parenting Self‐Efficacy (TOPSE) using data from the questionnaires previously completed in a controlled before–after study conducted in 2015 to evaluate a newsletter programme to help improve parenting. Mothers and fathers of newborns were asked to complete the TOPSE at the child's birth (t0), at 6 months (t1) and at 12 months (t2): 265 TOPSE questionnaires were collected at t0 (43%), 158 at t1 (26%) and 188 at t2 (31%).MethodsWe measured internal reliability using Cronbach's alpha for each of the eight domains of the TOPSE. The intracluster correlation coefficient (ICC) was used to evaluate the external reliability only for parents with more than one child. Responsiveness was measured by testing the ability of the questionnaire to detect differences between groups and times that we expected to be measurable, based on consolidated findings in the literature. Mean scores of PSE improved from t0 to t2 (Hypothesis 1), PSE was lower at baseline for first‐time parents than for those with multiple children (Hypothesis 2) and the improvement from t0 to t2 was stronger for first‐time parents than for parents with multiple children (Hypothesis 3).Results and ConclusionBased on our sample of questionnaires, the Italian version of the TOPSE was reliable for almost all of the domains except for Emotion, Self‐acceptance and Learning, which could be refined by re‐framing or dropping one item. External reliability was moderate, bearing in mind that the questionnaire was repeated at different times over 12 months, during which parents normally change. Responsiveness was good, especially for the Emotion and Empathy domains.
Reciprocal links between marijuana use and school adjustment in Black and White rural adolescents
Authors: May Emily M. , Witherspoon Dawn P. 
Published: July 2022

AbstractAlthough research has established that school adjustment is associated with marijuana use (MU) in adolescence, few studies have tested these associations bidirectionally. Using random intercepts cross‐lagged panel modeling, this study examined reciprocal associations between MU and school adjustment across 8th to 10th grade, including the transition to high school. Participants included 5470 rural adolescents (59% White, 41% Black) aged 12–17 years in 2002–2005. School adjustment factors predicted subsequent MU (i.e., higher self‐reported grades were protective for Black and White youth; valuing education was protective for Black youth; school behavior problems predicted increased MU across the transition to high school for White youth). MU had several adverse effects on school adjustment, particularly during the transition to high school.
Bone preservation or augmentation simultaneous with or prior to dental implant placement: A systematic review of outcomes and outcome measures used in clinical trials in the last 10 years
Authors: Shi Jun‐Yu , Montero Eduardo , Wu Xin‐Yu , Palombo David , Wei Shi‐Min , Sanz‐Sánchez Ignacio 
Published: July 2022

AbstractAimTo evaluate outcome measures and methods of assessment in clinical studies on bone augmentation/preservation procedures for the placement of dental implants.Materials and MethodsA systematic search was performed on three databases from January 2011 to April 2021 to identify clinical studies reporting on any type of bone augmentation/preservation procedure. The outcomes that have been used to assess efficacy or performance in each study were registered and assigned to different domains (group of outcomes). The review followed the Preferred Reporting Items for Systematic Review and Meta‐Analyses statement.ResultsSeven‐hundred and eighty‐three publications were included. Only 81.8% of the papers had a clear definition of their primary outcome. The rate of complications (59.3%), implant survival (58.2%), 3D radiographic bone gain/change (30%), marginal bone level (MBL; 29%), and histological outcomes (25.5%) were the most frequently reported outcome domains. The most commonly used primary outcome was 3D radiographic bone gain/change (25.8%), followed by implant survival (13.0%). Patient‐reported outcome measures (PROMs) were reported in 15.7% of studies. Differences in the reported outcomes were observed among different types of bone preservation/augmentation interventions (i.e., alveolar ridge preservation, immediate implants, horizontal and/or vertical ridge augmentation, and sinus floor augmentation).ConclusionWithin the past decade, great heterogeneity was observed among the outcomes considered in studies evaluating bone preservation/augmentation procedures. Three‐dimensional radiographic bone gain/change was the most routinely reported main outcome variable, while PROMs were rarely reported.
Alveolar ridge preservation in extraction sockets of periodontally compromised teeth: A systematic review and meta‐analysis
Authors: Atieh Momen A. , Alnaqbi Maitha , Abdunabi Farida , Lin Lifeng , Alsabeeha Nabeel H. M. 
Published: July 2022

AbstractObjectivesAlveolar ridge preservation (ARP) procedures can limit bone changes following tooth extraction. However, the role of ARP in periodontally compromised socket lacks strong scientific evidence. The aim of this systematic review and meta‐analysis was to evaluate the outcomes of ARP following extraction of periodontally compromised teeth in comparison with extraction alone in terms of hard tissue changes, need for additional augmentation at the time of implant placement, and patient‐reported outcomes.Material and MethodsElectronic databases were searched to identify randomized controlled trials (RCTs) that compared ARP in periodontally compromised sockets with spontaneous socket healing. The risk of bias was assessed using the Cochrane Collaboration's risk of bias tool.ResultsFive studies with 134 extraction sockets in 126 participants were included. Of these, ARP was performed in 77 sites, while the remaining sites were intentionally left to heal without any ARP treatment. The follow‐up time varied between 6 and 12 months. Overall meta‐analysis showed significant differences in changes in ridge height (mean difference (MD) −0.95; 95% confidence interval (CI) −1.43 to −0.47; p = .0001) and bone volume (MD −38.70; 95% CI −52.17 to −25.24; p < .0001) in favor of ARP. The use of ARP following extraction of periodontally compromised tooth was also associated with significantly less need for additional bone grafting at the time of implant placement.ConclusionsWithin the limitation of this review, ARP following extraction of periodontally compromised teeth may have short‐term positive effects on alveolar ridge height and bone volume and minimize the need for additional augmentation procedures. However, the evidence is of very low to low certainty.
Cross‐border and domestic minority acquisitions and financial constraints: Reaping big benefits from small shareholders
Authors: Macoris Lucas S. , Kabbach‐de‐Castro Luiz Ricardo , Kalatzis Aquiles E.G. , Boehe Dirk M. 
Published: July 2022

AbstractResearch Question/IssueDo the motivations of cross‐border minority acquisitions differ from those of domestic minority acquisitions? We examine and compare the underlying motivations for and consequences of domestic and cross‐border minority acquisitions by analyzing data from transactions that took place across 31 countries over a 13‐year period.Research Findings/InsightsUsing a sample of 11,926 domestic and cross‐border minority acquisitions, we show that the interplay of financing and country‐level governance motives is the main driver of such deals in both settings. We find that financially constrained firms are more likely to engage in both domestic and cross‐border minority acquisitions, even in the face of higher information asymmetry and transaction costs that international transactions entail. In the wake of either domestic or cross‐border deals, financially constrained firms' long‐term debt increases; their short‐term debt, cash holdings, and equity decrease. The greater likelihood of minority acquisitions of financially constrained firms is explained by the degree of corporate governance institutions in the country in which the targeted firm is based and by differences in levels of creditor and shareholder protections between the home countries of the targeted and acquiring firms involved. Our results remain robust after controlling for alternative explanations such as the contracting motive, the gravity model of foreign transactions, economic development levels, and differences in tax and exchange rates.Theoretical/Academic ImplicationsOur results extend prior literature on mergers and acquisitions that have focused solely on control transfers or domestic deals. We provide empirical evidence for the importance of jointly considering financing and governance motivations in seeking to explain domestic and cross‐border minority acquisitions and their consequences in alleviating financial constraints. We provide new evidence on how firm‐ and country‐level characteristics interact to affect minority acquisitions.Practitioner/Policy ImplicationsOur results offer valuable insights for business policy by highlighting how firms can circumvent financial constraints through partial integration, especially in cross‐border settings. The results also offer evidence of beneficial ex post outcomes for targeted firms' leverage and liquidity. In terms of public policy, the results show that minority shareholder protections improve the equity market and provide a positive externality to the debt market through a certification effect.
Effects of a multi‐functional adjuvant on efficacy of methoxyfenozide (SC24%) and spinosad (SC24%) to control the European grapevine moth, Lobesia botrana
Authors: Mosallanejad Hadi , Broomand Asghar 
Published: July 2022

AbstractThe study was undertaken to evaluate the effects of a multi‐functional adjuvant on the field efficacy of two insecticides, methoxyfenozide (SC24%) and spinosad (SC24%), against Lobesia botrana in Iran. The efficacy was evaluated from the experimental plots at 3, 7, 14 and 21 days after treatment. Our results indicated that the adjuvant was able to enhance the efficacy of both methoxyfenozide and spinosad against L. botrana at each interval. The increased efficacy was due to the lower values of surface tension and to the improved contact angle parameters of the spray solutions. By adding adjuvant in the spraying liquid, it was possible to have a control efficiency very similar to the treatment using the recommended rates, even when the application rate was reduced by 20%. Our results underline the importance of adjuvants in improving the field efficacy of insecticides against L. botrana.
Advanced general particle dynamics with nonlocal foundation for fracture analysis
Authors: Zhou Xiao‐Ping , Yao Wu‐Wen , Berto Filippo 
Published: July 2022

AbstractThe general particle dynamics (GPD), which is based on the kernel approximation method and Navier–Stokes equation, was developed from smoothed‐particle hydrodynamics to simulate the fracture behaviors by using the collective of damage variable to describe the damage evolution behaviors. In this paper, an advanced GPD with a nonlocal foundation is proposed for better description of the solid mechanics. The nonlocal vector calculus and microscopic constitutive model are employed to derive the governing equations in the proposed theory. The novel GPD with a nonlocal core is a generalization, which permits the inclusion of the microscopic constitutive model and the multi‐scale modeling compared with the previous GPD. To accomplish this generalization, the relationship between GPD and the previous kernel‐based theory is established. The novel GPD is superior in the fracture problems and multi‐scale modeling. Some numerical experiments are launched to verify the ability of the novel GPD.