bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comorbidities, pharmacologic interventions, and mechanical interventions associated with mortality in isolated diastolic left heart failure: lessons from a national database and a clinical simulator
Authors: Loomba Rohit S. , Ikeda Nobuyuki , Farias Juan S. , Villarreal Enrique G. , Flores Saul 
Published: October 2022

Abstract
Background: Diastolic heart failure may be noted in pediatric patients with congenital heart disease, cardiomyopathy, or malignancies requiring chemotherapy, but the available data are scarce, and often derived from adult trials or based on theoretic or anecdotal evidence.
Methods: Data between 2016 and 2021 were obtained from Pediatric Health Information System database. Patients < 18 years of age with isolated diastolic heart failure admitted to intensive care unit at some point during admission were included. They were divided into patients with and without inpatient mortality. Patients’ demographics, comorbidities using ICD-10 codes, and pharmacologic interventions were also recorded. Univariate analysis was done in demographics, comorbidities, pharmacologic interventions, and mechanical interventions between admissions with and without mortality. Multivariable logistic regression was done for inpatient mortality and multivariable linear regression was done for total hospital length of stay in survivors.
Results: Isolated diastolic heart failure comprised 0.5% of critically ill pediatric patients. 121 (5%) experienced mortality among the 2,273 admissions in the final analyses. Milrinone and angiotensin converting enzyme inhibitor were found to be associated with decreased mortality. Increasing age and diuretics were associated with decreased total hospital length of stay in survivors.
Conclusion: Pediatric critical care admissions with isolated diastolic left heart failure have a 5% mortality. Several comorbidities and interventions are associated with increased mortality with milrinone and angiotensin converting enzyme inhibitors being associated with decreased risk of mortality. When only admissions with survival to discharge are considered, older age and diuretics are associated with lower total hospital length of stay.
Development and validation of a severity scale based on clinical manifestations for patients with cerebral venous thrombosis
Authors: Li Min , Wang Nanbu , Duan Jiangang , Chen Jian , Zhang Xuxiang , Meng Ran , Ji Xunming 
Published: October 2022

Abstract
Introduction
: Cerebral venous thrombosis (CVT) is a rare subtype of stroke. However, existing scales were insufficient to evaluate the overall severity of CVT. The aim of this study is to develop and validate a CVT severity scale.
Methods
Items 1–11 were directly derived from NIHSS. New items were generated from a literature review and focus group discussion. 170 CVT patients were prospectively recruited from 26 top tertiary hospitals in China Mainland from January 2021 to May 2022 to validate the CVT severity scale. The CVT severity scale, NIHSS, mRS and GCS was rated at admission. The lumbar puncture opening pressure was also recorded. 20 randomly selected CVT patients were rated with the CVT severity scale again 24 hours later. The clinical outcome of CVT was evaluated by mRS at 6 months after baseline.
Results
We successfully established a CVT severity scale with 18 items. Exploratory factor analysis showed that 18 items were attributed to factor 1 (focal neurological deficits), factor 2 (diffuse encephalopathy), factor 3 (intracranial hypertension) and factor 4 (cavernous sinus syndrome). CVT severity scale was positively correlated with ICP, NIHSS and mRS, and negatively correlated with GCS at baseline. CVT severity scale > 3 or factor 3 > 2 indicated intracranial hypertension. CVT severity scale > 10 indicated poor clinical outcome at 6 months of follow-up. Meanwhile, CVT severity scale showed high internal consistency and test-retest reliability.
Conclusions
The CVT severity scale included 18 items encompassing 4 domains of focal neurological deficits, diffuse encephalopathy, IH and cavernous sinus syndrome. CVT severity scale correlated well with ICP, NIHSS, mRS and GCS. Patients with CVT severity scale > 10 can be defined as severe CVT. The CVT severity scale may serve as a valid and reliable tool for measuring the overall severity of CVT.
Preoperative lymphocyte to white blood cell ratio predicts the survival of patients with hepatocellular carcinoma after liver resection: A multicenter study
Authors: Qin Li , Ji Ai-Jing , Zhou Zi-Long , Zhang Yu , Xie Fei , Yu Yu , Leng Shu-Sheng , Li chuan 
Published: October 2022

Abstract
Background
Lymphocytes play a key anticancer role. However, there is little information concerning the prognostic utility of the lymphocyte to white blood cell ratio (LWR) for patients with hepatocellular carcinoma (HCC) after liver resection.
Methods
The data of patients with HCC who underwent liver resection at 5 centers were retrospectively reviewed. X-Tile software was used to determine the optimal cutoff values of the inflammation-based models. Univariate and multivariate analyses were used to identify the independent risk factors for both recurrence-free survival (RFS) and overall survival (OS). Multivariate Cox proportional hazard models were used to assess the independent risk factors for RFS and OS.
Results
A total of 1591 patients were included in this study. The multivariate analyses revealed that LWR was an independent risk factor for both RFS (HR = 1.190, 95% CI = 1.037–1.365, P = 0.013) and OS (HR = 1.300, 95% CI = 1.098–1.539, P = 0.002) for HCC patients after liver resection. LWR showed a higher predictive capacity for both RFS and OS than other inflammation-based models for patients with HCC after tumor resection. The 5-year RFS and OS were 42.9% and 60.8%, respectively, for HCC patients with a high LWR, which were significantly higher than those with a low LWR (36.9% for RFS and 49.0% for OS, both P < 0.001).
Conclusions
Preoperative LWR may serve as a novel marker to predict the survival of HCC patients after liver resection. Low LWR was associated with a high incidence of postoperative recurrence and mortality.
Transient electromagnetic smoke ring due to a grounded-wire source
Authors: Chen Weiying , Xue Guoqiang , Lei Kangxin , Song Wanting 
Published: October 2022

Abstract
The concept of a smoke-ring in electromagnetic fields can be used to describe the spatial distribution and diffusion of electromagnetic fields with either frequency or time. This provides an intuitive basis for qualitative interpretation of artificial source electromagnetic measurement results. The existing discussions regarding this field of study have mainly focused on the smoke rings of a magnetic dipole or loop source. The smoke ring of the other commonly used grounded-wire sources in the time domain was investigated. The results show that the smoke ring of grounded-wire sources is more complex than that of magnetic sources. A grounded-wire source can generate induced current in both the horizontal and vertical directions. The horizontal induced current consists of two parts. At the early stage, when the source has just been turned off, there is a low-amplitude and fast-diffuse opposite return current. With time it becomes positive, and reaches a maximum, then decreases. The horizontal induced current maximum diffuses downward perpendicular to the surface, and the vertical induced current maximum diffuses at 45 degrees from the earth’s surface with a faster diffusion velocity, which is roughly 5 times that of the horizontal induced current. The smoke ring of the horizontal induced current more closely resembles the shape of a basin, while that of the vertical induced current is more like two separate jars. Finally, the respective imaging depths estimated based on the horizontal and vertical induced currents are 0.92 and 1.25 times the diffusion depth.
A pan-cancer analysis of the oncogenic role of COVID-19 risk gene Leucine Zipper Transcription Factor-Like Protein 1 (LZTFL1) in human tumors
Authors: Mo Jihao , Zhang Zhenzhen , Wang Daping , Wang Meimei , Wang Lei 
Published: October 2022

Abstract
Population-based studies showed that COVID-19 infection causes higher death rate in cancer patients. However, the molecular mechanism of COVID-19 with cancer is still largely unknown. Here we analyzed the Leucine Zipper Transcription Factor-Like Protein 1 (LZTFL1) which is the most significant gene associated with COVID-19. First, we explored the potential oncogenic roles of LZTFL1 through transcriptome data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. LZTFL1 is significantly low expressed in 11 of 34 kinds of cancers we analyzed. Consistent with the mRNA expression data, the protein expression of LZTFL1 in lung adenocarcinoma (LUAD), clear cell renal cell carcinoma (ccRCC), Uterine corpus endometrial carcinoma (UCEC), and ovarian cancer (OV) patients are significantly decreased compared to healthy tissues. The survival analysis from the Kidney renal clear cell carcinoma (KIRC), Rectum adenocarcinoma (READ), and Uveal Melanoma (UVM), the LZTFL1 high expression group have a significantly higher survival rate compared to the low expression group. Taken together, LZTFL1 acts as a cancer suppressor gene for several cancers. Moreover, LZTFL1 expression was associated with the cancer-associated fibroblast infiltration in several tumors including Bladder Urothelial Carcinoma (BLCA), Breast invasive carcinoma (BRCA), Esophageal carcinoma (ESCA), Head and Neck squamous cell carcinoma (HNSC), Lung squamous cell carcinoma (LUSC), and Pancreatic adenocarcinoma (PAAD). Gene ontology analysis showed that cilium organization, positive regulation of establishment of protein localization to telomere and SRP-dependent cotranslational protein targeting to the membrane were involved in the function mechanisms related to LZTFL1. Our studies offer a relatively comprehensive understanding of the oncogenic roles of LZTFL1 across different kinds of tumors.
Optimized machine learning approach may improve understanding of medial tibial stress syndrome in military male personnel
Authors: Sobhani Vahid , Asgari Alireza , Shakibaei Abolfazl 
Published: October 2022

Abstract
This study investigates the applicability of optimized machine learning approach for the prediction of MTSS using anatomic and anthropometric predictors. To this end, 180 recruits were enrolled in a cross-sectional study (30 MTSS (30.36 ± 4.80 years) and 150 normal (29.70 ± 3.81 years)). Twenty-five predictors/features including demographic, anatomic, and anthropometric variables were selected as risk factors. Bayesian optimization method was used to evaluate the most applicable machine learning algorithm with tuned hyperparameters on the training data. Three experiments were performed to handle the imbalances in the data set. The validation criteria were accuracy, sensitivity, and specificity. The highest performance (even 100%) observed for the Ensemble and SVM classification models while using at least 6 and 10 most important predictors in experiments 1 and 3 respectively. In experiment 2 the best performance (accuracy = 88.89%, sensitivity = 66.67% and specificity = 95.24%) was achieved for the Naive Bayes classifier with 10 most important features. The Naive Bayes, Ensemble, and SVM methods could be the primary choices to apply machine learning approach in MTSS risk prediction. These predictive methods alongside the eight common proposed predictors might help to more accurately calculate the individual risk of developing MTSS at the point of care.
APOE ɛ4, but not polygenic AD risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals
Authors: Håglin Sofia , Koch Elise , Hackenhaar Fernanda Schäfer , Nyberg Lars , Kauppi Karolina 
Published: October 2022

Abstract
The hippocampus is early affected in Alzheimer’s Disease (AD) and altered hippocampal functioning influences normal cognitive aging. Here, we used functional MRI to assess if the APOE ɛ4 allele or a polygenic risk score (PRS) for AD was linked to longitudinal changes in memory-related hippocampal activation also in normal aging (baseline age 50–95, n = 292; n = 182 at four-year follow-up, subsequently non-demented for at least two years). Mixed-models were used to predict level and change in hippocampal activation by APOE ɛ4 status and PRS based on gene variants previously linked to AD at p ≤ 1, p < 0.05, or p < 5e-8 (excluding APOE). APOE ɛ4 and PRSp<5e−8 significantly predicted AD risk in a larger sample from the same study population (n = 1,542), while PRSp≤1 predicted memory decline. APOE ɛ4 was linked to decreased hippocampal activation over time, with the most prominent effect in the posterior hippocampus, while PRS was unrelated to hippocampal activation at all p-thresholds. These results suggests a link for APOE ɛ4, but not for AD genetics in general, on functional changes of the hippocampus in normal aging. Among possible mechanisms are breakdown of the blood-brain barrier in APOE ɛ4 carriers, recently linked to cognitive aging independent from AD pathologies.
Ir Spectrometric Studies of Ccl4 and Ar Gas Mixtures.
Authors: Korshikov Yevgeniy , Sokolov Dmitriy , Potapchenko Angelika , Aldiyarov Abdurakhman 
Published: October 2022

Abstract
IR-spectrometric studies of cryo-deposition processes and properties of thin films of cryo-vacuum condensates of a mixture of carbon tetrachloride and argon obtained by physical cryo-vacuum deposition at various concentrations have been carried out. The measurements were carried out in the temperature range 11 K − 100 K and the pressure of the gas phase 10− 8 Torr − 10− 4 Torr. The film thickness in all experiments performed was d = 2 µm. The vibrational spectra of CCl4 in an argon matrix were measured in the frequency range 400–4200 cm− 1 at mixture concentrations (CCl4 + Ar) as: (10%-90%; 5%-95%; 1%-99%) and after sublimation of the argon matrix. For the (CCl4 + Ar) system, thermal adsorption curves for the yield of the matrix gas (Ar) were obtained in the temperature range of 40K and 90K. The existence of cryocapture of CCl4 molecules of the substance of the Ar matrix was found. The results obtained suggest that, in low-temperature studies of self-organization processes in thin films, carbon tetrachloride can be used as a matrix.
Transformer-based Environmental Sound Classification Modeling by Jointing Multi-class Classification and Similarity Clustering
Authors: Zhou Xing , Zhao Ming 
Published: October 2022

Abstract
As environmental sound signal is not as regular as speech, it has varying temporal structures and is more difficult to distinguish. Previous research on Environmental Sound Classiﬁcation (ESC) has designed sophisticated methods to extract feature from raw waveforms directly, but this may not be generalized well across different ESC tasks. We proposed an end-to-end audio scene classification network which is only based on the log-mel feature. First, we used Transformer network to encode signals that can capture crucial temporal information from self-attention. Then we combined Multi-class classifier with similarity clustering so as to maximize the distance between different classes. At last, we visualized the Transformer’s ability to locate important temporal information. The performance on ESC10 and ESC50 showed that our architecture reached an average accuracy of 95.3% and 84.2%, respectively. That was an achievement of new state-of-the-art performance with only log-mel input. Meanwhile, that is nearly equivalent to the best performance of the model based on raw waveform or combined feature method.
Description of Sarcocystis platyrhynchosi sp. nov. (Apicomplexa: Sarcocystidae) infection in domestic ducks Anas platyrhynchos (Anseriformes: Anatidae) in China
Authors: Hu Junjie , Zhang Mingzhu , Wu Zhipeng , Zeng Hongxia , Tao Jianping 
Published: October 2022

Abstract
Background: Data on the genus Sarcocystis in waterfowls are very limited. To the best of our knowledge, the species of Sarcocystis have previously never been recorded in ducks in China.
Methods: Leg muscles were obtained from 26 domestic ducks Anas platyrhynchos in 2021 in China. Sarcocysts were observed using light microscopy (LM) and transmission electron microscopy (TEM). Individual sarcocysts from different hosts were selected for DNA extraction, and three genetic markers, namely, 18S ribosomal DNA (18S rDNA), 28S ribosomal DNA (28S rDNA), and mitochondrial cytochrome oxidase subunit 1 (cox1), were amplified, sequenced, and analyzed.
Results: Sarcocysts were found in 3 of the 28 (10.7%) domestic ducks. Under LM, the sarcocysts were microscopic and had brush-like villar protrusions (vps), measuring 3.8–4.3 μm-long. Ultrastructurally, the sarcocyst wall contained numerous lancet- or leaf-like vp. Each vps narrowed in the stalk and contained bundled microtubules extended into the ground substance. Comparison of the newly obtained sequences with those previously deposited in GenBank indicated that the most similar sequences were those of S. halieti ex Phalacrocorax carbo or Sturnus vulgaris,and S. calchasi ex Columba livia, with an identity of 99.1% at 18S rDNA, S. wenzeli ex Gallus gallus, with an identity of 95.9–96.0% identity at the 28S rDNA, and S. speeri ex opossum, with an identity of 98.2% at the mitochondrial cox1. Additionally, at the three loci, the newly obtained sequences unambiguously differed from those of Sarcocystis spp. obtained from Anseriformes birds. Phylogenetic analysis based on the three loci placed the parasite within a group containing Sarcocystisspp. that utilize birds or dogs as intermediate hosts. The parasite was proposed as a new species, named Sarcocystis platyrhynchosi.
Conclusions:Sarcocysts were recorded in domestic ducks in China for the first time. Morphologically and molecularly, the sarcocysts remarkably differed from those of Sarcocystis spp. previously reported in different intermediate hosts, and S. platyrhynchosi was proposed for the new species. Depending on the limited date provided for Sarcocystisspp. in Anseriformes birds, there is confusion concerning the relationships of the morphologically similar species of Sarcocystisin Anseriformes birds. Therefore, more research on these closely related species of Sarcocystis needs to be undertaken in the future.
Mild hypothermia alleviates oxygen-glucose deprivation/reperfusion-induced apoptosis by inhibiting ROS generation, improving mitochondrial dysfunction and regulating DNA damage repair pathway in PC12
Authors: Zhou Tianen , Mo Jierong , Xu Weigan , Hu Qiaohua , Liu Hongfeng , Fu Yue , Jiang Jun 
Published: October 2022

AbstractThe brain ischemia/reperfusion (I/R) injury have a great impact on human life and property safety, as far as we know, mild hypothermia (MH) is an effective measure which reduces neuronal injury. However, the precise mechanism is not extremely clear. The purpose of this study was to explore whether mild therapeutic hypothermia can play a protective role in nerve cells dealing with brain I/R injury and its specific mechanism in vitro. A flow cytometer, cell counting kit-8 (CCK-8) assay, lactate dehydrogenase (LDH) release assay were performed to detect apoptotic rate of cells, cell viability and cytotoxicity respectively, while reactive oxygen species (ROS) assay kit, JC-1 fluorescent methods, immunofluorescence, western blot were used to explore ROS, mitochondrial transmembrane potential (Δψm), mitochondrial permeability transition pore (MPTP), expression of proteins respectively. The result indicated that the activity was decreased, while the cytotoxicity and apoptosis rate were increased after treating with OGD/R in PC12, however, MH could antagonize this phenomenon. Strangely, treating with OGD/R increased the release of ROS and the transfer of Cytochrome C (Cyt-C) from mitochondria to cytoplasm, besides, it also upregulated the expression of γH2AX, Bax and Clv-caspase3 but downregulated the expression of PCNA, Rad51, Bcl-2 and inhibited the function of mitochondria in PC12, the opposite trend was observed after MH treatment. Therefore, our results suggest that MH alleviates PC12 against oxygen-glucose deprivation/ reoxygenation-induced injury with the mechanism of inhibiting cell apoptosis by reducing ROS production, improving mitochondrial function, reducing DNA damage, and enhancing DNA repair.
Integrative transcriptomic and proteomic analysis show circulating osteoprogenitors to have a mixed immune and mesenchymal progenitor function in humans
Authors: Feehan Jack , Jacques Macsue , Kondrikov Dmitri , Eynon Nir , Wijeratne Tissa , Apostolopoulos Vasso , Gimble Jeffrey , Hill William , Duque Gustavo 
Published: October 2022

Abstract
Circulating osteoprogenitors (COP) is a population of cells in the peripheral circulation that possess functional and phenotypical characteristics of multipotent stromal cells (MSCs). While there is functional overlap, it is not known how COP cells are related to bone marrow (BM)-derived MSCs (BM-MSCs) and other better characterized stromal progenitor populations such as adipose-derived stromal cells (ASCs). This study compares COP cells to BM-MSCs and ASCs through detailed transcriptomic and proteomic analyses. COP cells have a distinct gene and protein expression pattern to BM-MSCs and ASCs, with a significantly stronger immune footprint, likely owing to their hematopoietic lineage. However, they also have a similar pattern of expression BM-MSCs and ASCs, in genes and proteins in progenitor cell differentiation and proliferation pathways. This study shows COP cells to be a unique but functionally similar population to BM-MSCs and ASCs, sharing their proliferation and differentiation capacity, but with a strong immune phenotype, with potential for translational regenerative medicine strategies.
Morphologic Study of the Corona Mortis Using the Simlife ® Technology
Authors: BEYA Robert , Jérôme DANION , Tanguy VENDEUVRE , My-Van NGUYEN , Arthur RENAULT , RICHER Jean-Pierre , HAUET HAUET , Cyril BREQUE , FAURE Jean-Pierre 
Published: October 2022

Abstract
Purpose
Open book pelvic ring fractures are potentially life-threatening, due to their instability and major haemorrhage risk. If a pelvic belt could initially control the bleeding, the definitive management involves an open reduction and internal fixation. However, the pelvic approach remains a technical challenge, as the surgeon wants to prevent any iatrogenic damage of the vascular loop located in the retropubic area called corona mortis (CMOR). Recently, the cadaver perfused SIMLife® technology has been developed to improve the surgeon training, out of the operating room. This study aimed to compare two models of cadaveric dissection, to assess the interest of the perfused SIMLife® in the identification of the CMOR and its topography.
Methods
Twelve human cadaveric pelvises have been dissected, following two protocols. Twelve hemipelvises of the dissections were performed without perfusion (Model A), whereas the 12 other hemipelvises have been prepared with the SIMLife® pulsatile perfusion (Model B). The prevalence, length, and diameter of the CMOR have been reported, along with the distance between the CMOR and the pubic symphysis.
Results
The CMOR has been found in 66,67% of the cases. The length, the diameter and the distance between the CMOR and the pubic symphysis were significantly higher in model B (respectively p = 0.029, p = 0.01, and p = 0.022).
Conclusion
These results suggest that the CMOR is easier to identify and to dissect with the SIMLife® perfusion. As part of the surgical training of any trauma surgeon, this model could help him to keep in mind the topography of the CMOR, to improve the open book lesion management.