bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencia de la gerencia estratégica en sinergia de las generaciones, en empresas peruanas, en el distrito de San Miguel- año 2015
Authors: Cárdenas Saavedra Abraham , Zulema Ybela Antón Estela , Cañamero Tuanama Nancy Isabel 
Published: January 2022

La investigación “Influencia de la Gerencia Estratégica en Sinergia de las Generaciones, en Empresas Peruanas, en el Distrito de San Miguel- Año 2015”, presento un tipo de investigación Básico, con diseños No experimental y Transversal. El objetivo general fue el determinar de qué manera, la Gerencia Estratégica influye en la Sinergia de las Generaciones, en Empresas Peruanas, ubicadas en el Distrito de San Miguel, en el Año 2015. Los Hallazgos Estadísticos de la investigación, utilizando el Modelo de Regresión y Correlación, y se halló una relación significativa de estas variables (p < 0.05), y permitió determinar la influencia de la variable independiente Gerencia Estratégica y sus dimensiones (método de la senda) sobre la variable dependiente Sinergia de la Generaciones, apoyándonos en el análisis realizado a la tabla de la distribución Beta de cada variable, y sus respectivas dimensiones. Como recomendación de la investigación, se hace necesario el definir lineamientos para ajustar las configuraciones generacionales actuales, para replantear la sinergia generacional en sus procesos estratégicos con la informática, para actualizar, y simplificar drásticamente los sistemas actuales de gestión de las Herramientas de internet, que incluyen adecuar normas y procedimientos de las ventas por Internet.Palabras clave. Gerencia Estratégica, Sinergia, Generaciones
ANEMIA POR DEFICIENCIA DE HIERRO EN NIÑOS MENORES DE 36 MESES
Authors: Diaz Tena Juan Angel , Horna Rubio Abraham Josué , Vidal Salinas Moises , Masias Ponce Sandra Karina 
Published: January 2022

Según la OMS la Anemia afecta a más de dos mil millones de personas en todo el mundo (25%) de la población mundial; en el Perú según la encuesta ENDES 2019 afecta al 40.1% de los niños de 6 a 35 meses. Este es un problema de salud pública.
El objetivo del estudio es evaluar la prevalencia de Anemia ferropénica, en niños menores de 36 meses, lo cual servirá en la prevención y el tratamiento de la Anemia. Se realizó una revisión sistemática de la literatura científica en Google Scholar, CINHAL, PubMed, Web of Science, Cochrane Library y Scopus. PubMed, ScienceDi-rect, Crossref, Directory of Open Access Journals. Se analizaron 30 articulos cientificos, priorizan literaturas del período 2015-2021, en idioma inglés, en el campo de las ciencias médicas. La magnitud de la anemia en menores de 36 meses es extremadamente alta, debido por su elevada velocidad de crecimiento y altos requerimientos de hierro, a lo que se suma las dietas bajas en hierro. En países en desarrollo hay una mayor cobertura de los programas de suplementación y fortificación de hierro, así como la desparasitación periódica, la alimentación adecuada con alimentos diversificados y capacitación a las madres sobre la anemia.
El clima organizacional y la motivación laboral del personal de la I.E. Imperio del Tahuantinsuyo 3049 Independencia, Lima, 2016
Authors: Zulema Ybela Antón Estela , Cañamero Tuanama Nancy Isabel , Cardenas Saavedra Abraham 
Published: January 2022

El presente trabajo tuvo como objetivo determinar el grado de relación que existe entre el “Clima organizacional y la Motivación laboral del personal de la I.E. Imperio del Tahuantinsuyo 3049 Independencia 2016”. La investigación desarrollada es básica, se empleó un diseño no experimental, transaccional con una población de 120 colaboradores, el grado de confiabilidad es de 0,966 para la variable clima organizacional compuesto por 40 ítems y para la variable motivación laboral fue de 0,889 variable compuesta por 30 ítems. Para medir la variable de estudio se empleó como instrumento el cuestionario, el cual fue debidamente validado y aplicado. La investigación se desarrolló bajo un enfoque cuantitativo, se empleó como método de investigación el hipotético deductivo. Los resultados demuestran que el grado de relación es moderada entre el clima organizacional y la motivación laboral donde el resultado de la correlación de Spearman fue de 0,591, en la I.E. Imperio del Tahuantinsuyo N° 3049 Independencia 2016 (r= 0,591 y p= 0,000). Palabras clave: Clima organizacional, Motivación laboral.
La Gestión Administrativa Municipal. Una aproximación Conceptual
Authors: Luna Sono Jaime , Luna Hernández Manuel Jesús 
Published: January 2022

La Gestión Administrativa Municipal, es hoy un factor clave en el desarrollo de las instituciones de gobiernos locales, y su estudio en profundidad, diagnóstico y mejoramiento incide de manera directa en el denominado espíritu del desenvolvimiento de las actividades administrativas internas de las municipalidades; como objetivo, por lo anterior en el presente documento, se realiza una aproximación conceptual que ayuda a evidenciar la importancia de la gestión administrativa municipal. De igual forma se exponen las diferentes herramientas y métodos, examinándose distintos artículos como de la autora argentina María, Raffino (2020) “Concepto de gestión en la administración”, que se pueden emplear para su medición y diagnóstico, que consideran numerosas variables que giran en torno a los valores de la gestión administrativa en el ámbito municipal, obteniéndose como resultados, las creencias, costumbres y prácticas de gestiones municipales, concluyéndose en no sólo la conceptualización, sino esclarecer las causas de la satisfacción e insatisfacción en los usuarios y su incidencia, en los cambios de gestión administrativa municipal.
Ship evacuation simulation using a game engine: Modelling, testing and validation
Authors: Montecchiari Gabriele , Bulian Gabriele , Gallina Paolo 
Published: January 2022

The topic of evacuation analysis plays an important role in the maritime field, because of its natural link to safety and also because of relevant SOLAS requirements. In this context, this paper focuses on the description, testing and validation of an agent-based mathematical model. As primary goal, the model has been developed targeting a use in evacuation simulations using immersive virtual reality, also with the possibility of real-time human participation. At the same time, the model is suitable also for standard evacuation simulations. The model has been developed starting from existing social force models and introducing a series of improvements, modifications, new modelling, and adaptations. The model is described in detail, providing and discussing all adopted parameters. The choice of a game engine as development environment is also discussed, highlighting benefits and limitations. Results from IMO test cases, validations using experimental data, and comparisons with FDS+Evac are presented. A more realistic test case, relevant to the maritime field, with a two-cabin-deck geometry is also presented, together with corresponding simulation results. Particular attention is paid to the post-processing and reporting of the results from Monte Carlo simulations, in order to properly reflect, quantify and emphasize the underlying aleatory uncertainty.
Long-Term Cognitive Decline Related to the Motor Phenotype in Parkinson’s Disease
Authors: Michels Jennifer , van der Wurp Hendrik , Kalbe Elke , Rehberg Sarah , Storch Alexander , Linse Katharina , Schneider Christine , Gräber Susanne , Berg Daniela , Dams Judith , Balzer-Geldsetzer Monika , Hilker-Roggendorf Rüdiger , Oberschmidt Carola , Baudrexel Simon , Witt Karsten , Schmidt Nele , Deuschl Günther , Mollenhauer Brit , Trenkwalder Claudia , Liepelt-Scarfone Inga , Spottke Annika , Roeske Sandra , Wüllner Ullrich , Wittchen Hans-Ulrich , Riedel Oliver , Kassubek Jan , Dodel Richard , Schulz Jörg Bernhard , Costa Ana Sofia , Reetz Kathrin 
Published: January 2022

Background: Parkinson’s disease (PD) is associated with various non-motor symptoms, including cognitive deterioration. Objective: Here, we used data from the DEMPARK/LANDSCAPE cohort to describe the association between progression of cognitive profiles and the PD motor phenotypes: postural instability and gait disorder (PIGD), tremor-dominant (TR-D), and not-determined (ND). Methods: Demographic, clinical, and neuropsychological six-year longitudinal data of 711 PD-patients were included (age: M = 67.57; 67.4% males). We computed z-transformed composite scores for a priori defined cognitive domains. Analyses were controlled for age, gender, education, and disease duration. To minimize missing data and drop-outs, three-year follow-up data of 442 PD-patients was assessed with regard to the specific role of motor phenotype on cognitive decline using linear mixed modelling (age: M = 66.10; 68.6% males). Results: Our study showed that in the course of the disease motor symptoms increased while MMSE and PANDA remained stable in all subgroups. After three-year follow-up, significant decline of overall cognitive performance for PIGD-patients were present and we found differences for motor phenotypes in attention ( β= –0.08, SE = 0.003, p < 0.006) and memory functions showing that PIGD-patients deteriorate per months by –0.006 compared to the ND-group (SE = 0.003, p = 0.046). Furthermore, PIGD-patients experienced more often difficulties in daily living. Conclusion: Over a period of three years, we identified distinct neuropsychological progression patterns with respect to different PD motor phenotypes, with early executive deficits yielding to a more amnestic profile in the later course. Here, in particular PIGD-patients worsened over time compared to TR-D and ND-patients, highlighting the greater risk of dementia for this motor phenotype.
PROBLEMS IN USING ICHNOFACIES FOR DEPOSITIONAL ENVIRONMENT INTERPRETATION CASE STUDY: THE CISAAR FORMATION, SUNGAI CISAAR, SUMEDANG DISTRICT, WEST JAVA, INDONESIA
Authors: Rizal Yan , ⠀ Aswan , Fifariz Reynaldy , Mulia Adityan 
Published: January 2022

Although numerous researchers have used trace fossils method to determine depositional environment, this method is still considered less robust. This is due to the finding of several similar trace fossils in two or more diverse environments, leading to irrelevancy in environmental interpretation. Therefore, we conducted this study in order to verify how powerful the trace fossil analysis is, by applying this method to interpret the depositional environment of the Cisaar Formation in the Cihanyir Tonggoh area, Sumedang Regency, West Java. We combined trace fossil study with foraminiferal assemblage analysis and vertical succession of related sedimentary units. For this study, 19 rock samples that have been collected from outcrop along 16 m traverse and 14 m measured stratigraphic sections were examined.The result of the study shows that shallow marine trace fossils which were developed at the edge of the shelf, were transported into the basin by gravitational mass flow and re-deposited as deep marine turbidites. Trace fossils were generally found in sandstones, while planktonic foraminifers were found in claystones-sandstones interbeds. This study concludes that to avoid inconsistency in the interpretation of the depositional environment, performing trace fossils method must be integrated with other methods, e.g. analysis of lithofacies and biofacies.
Genome-Wide Identification and Analysis of the Ascorbate Peroxidase (APX) Gene Family of Winter Rapeseed (Brassica rapa L.) Under Abiotic Stress
Authors: Ma Li , Qi Weiliang , Bai Jing , Li Haiyun , Fang Yan , Xu Jia , Xu Yaozhao , Zeng Xiucun , Pu Yuanyuan , Wang Wangtian , Liu Lijun , Li Xuecai , Sun Wancang , Wu Junyan 
Published: January 2022

Winter Brassica rapa (B. rapa) is an important oilseed crop in northern China, but the mechanism of its cold resistance remains unclear. Ascorbate peroxidase (APX) plays important roles in the response of this plant to abiotic stress and in scavenging free radicals. In this study, the roles of APX proteins in the cold response and superoxide metabolism pathways in rapeseed species were investigated, and a comprehensive analysis of phylogeny, chromosome distribution, motif identification, sequence structure, gene duplication, and RNA-seq expression profiles in the APX gene family was conducted. Most BrAPX genes were specifically expressed under cold stress and behaved significantly differently in cold-tolerant and weakly cold-resistant varieties. Quantitative real-time-PCR (qRT-PCR) was also used to verify the differences in expression between these two varieties under cold, freezing, drought and heat stress. The expression of five BrAPX genes was significantly upregulated in growth cones at 3 h of cold stress, while their expression was significantly lower at 24 h than at 3 h. The expression of Bra015403 and Bra003918 was significantly higher in “Longyou-7” growth cones than in other treatments. Five BrAPXs (Bra035235, Bra003918, Bra033040, Bra017120, and Bra031934) were closely associated with abiotic stress responses in B. rapa. These candidate genes may play important roles in the response of B. rapa to low temperature stress and provide new information for the elucidation of the cold resistance mechanism in B. rapa.
Preoperative Hemoglobin Level, Oxygen Saturation and Postoperative Outcomes in Children With Cyanotic Congenital Heart Disease: A Propensity-Score Matching Analysis
Authors: Zhou Dan , Deng Li-Jing , Ling Yun-Fei , Tang Meng-Lin 
Published: January 2022

BackgroundThe optimal preoperative hemoglobin (Hb) level is difficult to define in children with cyanotic congenital heart disease (CHD) due to hypoxemia-induced secondary erythrocytosis. This retrospective study integrated preoperative Hb and pulse oxygen saturation (SpO2) using the product of Hb × SpO2 to predict postoperative outcomes in children with cyanotic CHD.Patients and MethodsChildren aged &lt;18 years undergoing cardiac surgery with cyanotic CHD were included. The cutoff value of Hb × SpO2 was the age-adjusted lower limit of normal Hb (aaHb) in healthy children. The main outcomes were in-hospital death and the composite outcome of severe postoperative events. Multivariate logistic regression analysis and propensity score matching analysis were used to adjust for important confounders.ResultsThe presence of preoperative Hb × SpO2 &lt; aaHb was observed in 21.6% of cyanotic children (n = 777). Children with Hb × SpO2 &lt; aaHb had higher in-hospital mortality (12.5% vs. 4.6%, P &lt; 0.001) and composite outcome incidence (69.6% vs. 32.3%, P &lt; 0.001) than those with Hb × SpO2 ≥ aaHb. After propensity score matching, 141 pairs of children were successfully matched. Multivariate analysis showed that preoperative Hb × SpO2 &lt; aaHb was significantly associated with the composite outcome in the entire population (odds ratio = 4.092, 95% confidence interval = 2.748–6.095, P &lt; 0.001) and the matched cohorts (odds ratio = 2.277, 95% confidence interval = 1.366–3.795, P = 0.002).ConclusionOur results suggest that a preoperative Hb × SpO2 value below the lower limit of normal hemoglobin is a prognostic factor in cyanotic children undergoing cardiac surgery and is a potential criterion to evaluate preoperative anemia in this population.
Ocimum basilicum Essential Oil Modulates Hematotoxicity, Oxidative Stress, DNA Damage, and Cell Cycle Arrest Induced by β-cyfluthrin in Rat Liver
Authors: Jebur Ali B. , El-Sayed Raghda A. , El-Demerdash Fatma M. 
Published: January 2022

Pesticides are used in large quantities infrequently, resulting in environmental damage and health issues. The goal of the current study was to explore the ameliorating effect of Ocimum basilicum (Basil) leaves essential oil versus the harmful effects of β-cyfluthrin in rat liver. Male Wistar rats were classified at random into four groups; negative control (corn oil), basil leaves essential oil (BEO, 3 ml/kg), β-cyfluthrin (positive control) (β-Cyf; 15 mg/kg BW, 1/25 LD50), and BEO plus β-Cyf, respectively. The rats were given their doses orally every day for a month. Results revealed that BEO yielded 6.32 mg/g with 33 identified components, representing 97% of the total oil. BEO implicated a considerable level of total phenolic contents, DPPH radical scavenging capacity, ABTS activity, and FRAP. The treatment of β-Cyf dramatically elevated lipid peroxidation (TBARS and H2O2) (LPO), protein oxidation (PC, AOPP, and HYP), and considerably reduced enzymatic (SOD, CAT, GPx, GR, and GST) and non-enzymatic (GSH) antioxidants. After β-Cyf treatment, hematological parameters, body and liver weights, enzyme activity (AST, ALT, ALP, and LDH), as well as protein, albumin, globulin, and total bilirubin levels were all considerably affected. Furthermore, β-Cyf increased the expression of pro-inflammatory genes (TNF-α, IL-6) as well as DNA damage and cell cycle arrest in the G0/G1 phase and decreased the number of cells in S and G2/M phase of liver cells. Moreover, rats given BEO then intoxicated with β-Cyf showed substantial changes in the majority of the parameters tested. Finally, BEO was shown to have high antioxidant efficacy in combating β-Cyf toxicity because of its high phenolic content.
Correlation Between iXip and Final Pathology in Patients Affected by Prostate Cancer Undergoing Radical Prostatectomy: A Multicenter Prospective Trial (PROXIMA—PROstate iXip Index Multicenter Analysis)
Authors: Francavilla Simone , Lonati Chiara , Sandri Marco , Abate Andrea , De Marzo Enrico , Palumbo Carlotta , Aretano Lucia , Belotti Stefano , Peroni Angelo , Peviani Alessandro , Ferretti Stefania , Da Pozzo Luigi Filippo , Roscigno Marco , Calza Stefano , Guerini Agostino , Sigala Sandra , Simeone Claudio , Antonelli Alessandro 
Published: January 2022

IntroductionThe Immune compleX Predictive Index (iXip) is a predictive tool for prostate cancer (PCa) diagnosis that integrates PSA, PSA-IgM, prostate volume, and patient age. The aim of the study was to assess the correlation between iXip and clinically significant PCa in patients who underwent radical prostatectomy.Material and MethodsA prospective multicenter study was conducted from February 2018 to August 2019 enrolling 235 patients. Stepwise-selected predictors were used to estimate multivariate regression models for each outcome, the reference model with only the set of predictors and the same model with the addition of iXip. The prediction accuracy of the two models was assessed calculating the partial area under the receiver operating characteristic curve.ResultsThe ROC curve analysis showed significant differences in terms of partial area under the curve between iXip and pathological Gleason Score ≥ 7 and between iXip and tumor volume ≥ 2.5 mm3. The scatter plot analysis showed a positive linear correlation between iXip and tumor volume (considered as a continuous variable). The subpopulations with pT3–4 disease and cT3 disease and with positive surgical margins showed a significant linear relationship between iXip and tumor volume.ConclusionWe found elements supporting a possible correlation between iXip and aggressive PCa in terms of Gleason Score ≥ 7 and tumor volume ≥ 2.5 mm3.
PEDAGOGICAL CONDITIONS FOR ENHANCING LEARNING AND COGNITIVE ACTIVITIES OF SENIOR PUPILS USING ICT
Authors: Алисултанова Э. Д. , Ибрагимова М. С. , Исаева М. З. 
Published: January 2022

Данная статья посвящена исследованию условий активизации учебно-познавательной деятельности обучающихся при широком использовании современных инфокоммуникационных технологий. Рассмотренные проблемы цифровой педагогики актуализированы глобальными изменениями социально-экономической, политической, культурной, образовательной реальности, связанной с цифровизацией всех сфер жизнедеятельности человека. Основной акцент в работе поставлен на изучение влияния познавательных процессов при определении выбора профессии и на их отношение к учебной деятельности. Современное общество нацелено в своей деятельности на человеческий потенциал, способный быстро ориентироваться в огромных информационных потоках и имеющий высокий уровень интеллекта. В этом контексте современное развитие информационно-коммуникационных технологий диктует потребность в инициативных, всесторонне развитых личностях, способных к творчеству, постоянному самосовершенствованию, самообразованию и саморазвитию, что актуализирует проблему развития познавательной активности обучающихся средней школы. В статье приведены аналитические исследования экспериментальных данных проверки эффективности методик формирования познавательной активности старшеклассников на уроках технологии с использованием информационно-коммуникационных технологий.
This article is devoted to the study of the conditions for enhancing the educational and cognitive activity of students with the widespread use of modern infocommunication technologies. The considered problems of digital pedagogy are actualized by global changes in the socio-economic, political, cultural, educational reality associated with the digitalization of all spheres of human life. The main emphasis in the work is placed on the study of the influence of cognitive processes in determining the choice of a profession and on their relationship to educational activities. Modern society is focused in its activities on human potential, capable of quickly navigating huge information flows and having a high level of intelligence. In this context, the modern development of information and communication technologies dictates the need for proactive, comprehensively developed individuals capable of creativity, constant self-improvement, self-education and self-development, which actualizes the problem of developing the cognitive activity of secondary school students. The article presents analytical studies of experimental data for testing the effectiveness of methods for the formation of cognitive activity of high school students in technology lessons using information and communication technologies.
OGNITIVE INSTALLATIONS AS A METHODOLOGICAL FRAMEWORK OF SCIENTIFIC KNOWLEDGE
Authors: Бондаренко Т. А. , Власова В. С. 
Published: January 2022

Рассматриваются когнитивные установки, являющиеся основой методологических знаний в научном познании. Предметом исследования выступают принцип доверия субъекту познания, конвенции, символы и метафоры. Ставится задача реконструировать интенциональную функцию когнитивных установок и показать эвристическую ценность когниций в познании.
Cognitive attitudes that are the basis of methodological knowledge in scientific cognition are considered. The subject of the study is the principle of trust in the subject of cognition, conventions, symbols and metaphors. The task is to reconstruct the intentional function of cognitive attitudes and to show the heuristic value of cognitions in cognition.