bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mild drought conditions at the tillering stage promote dry matter accumulation and increase grain weight in drip-irrigated spring wheat (Triticum aestivum L.)
Authors: Ma Yilin , Cai Jingyi , Bie Shuting , Che Ziqiang , Jiang Guiying , Liu Jianguo 
Published: January 2025

IntroductionIn order to elucidate the physiological mechanism of post-flowering assimilate transport regulating the formation of yields in arid regions and to provide technological support for further water-saving and high yields in the wheat region in Xinjiang, we conducted a study on the effects of different fertility periods and different degrees of drought and re-watering on the post-flowering dry matter accumulation and transport of spring wheat and the characteristics of grain filling.MethodsIn two spring wheat growing seasons in 2023 and 2024, a split-zone design was used, with the drought-sensitive variety Xinchun 22 (XC22) and drought-tolerant variety Xinchun 6 (XC6) as the main zones and a fully irrigated control during the reproductive period [CK, 75%~80% field capacity (FC)], with mild drought at the tillering stage (T1, 60%~65% FC), moderate drought at the tillering stage (T2, 45%~50% FC), mild drought at the jointing stage (J1, 60%~65% FC), and mild drought at the jointing stage (J2, 45%~50% FC) as the sub-zones. ResultsThe dry matter accumulation of the aboveground parts of wheat (stem sheaths, leaves, and spikes), the transfer rate and contribution rate of nutrient organs, the maximum filling rate (Vmax), and the mean filling rate (Vmean) increased significantly after re-watering in the T1 treatment, and decreased with the deepening of the degree of water stress. The 13C isotope tracer results also showed that the T1 treatment increased the distribution rate of 13C assimilates in the grain at maturity. Correlation and principal component analyses showed that grain weight was highly significantly and positively correlated with stem sheath, leaf, and spike dry matter accumulation, amount of nutrient organ post-flowering transports, transport rate, contribution rate, the onset and the termination time of the rapid growth period, Vmax, and Vmean, and stem sheath and spike dry matter accumulation had a direct effect on grain weight. While the two varieties performed differently among the treatments, both exhibited optimal performance in the T1 treatment. DiscussionIn conclusion, mild drought at the tillering stage (60%-65% FC) was the best model for water conservation and high yield of wheat under the conditions of this trial.
Age-associated alterations in immune and inflammatory responses in captive olive baboons (Papio anubis)
Authors: Mulholland Michele M. , Nehete Bharti P. , DeLise Ashley , Achorn Angela M. , Pytka Lisa M. , Nehete Pramod N. 
Published: January 2025

IntroductionAdvanced age is a primary risk factor for many chronic diseases and conditions; however, age-related immune dysregulation is not well understood. Animal models, particularly those that resemble human age-related physiological changes, are needed to better understand immunosenescence and to improve health outcomes. Here, we explore the utility of the olive baboon (Papio anubis) in studying age-related changes to the immune system and understanding mechanisms of immunosenescence.MethodsWe examined immune cell, inflammatory responses, cytokines, and cortisol levels using hematology and flow cytometry, mitogen stimulation, multiplex cytokine assay, and cortisol immunoassay.Results and DiscussionOur results reveal significant age effects on numerous immune and inflammatory responses. For instance, adult and aged monkeys exhibited significantly fewer monocytes than young monkeys. After stimulation with Con A and PWM (separately), we found that old baboons had higher INFγ expression compared to young baboons. Similarly, after stimulation with LPS and PWM (separately), we found that old baboons had higher TNFα expression compared to young baboons. These findings suggest that the olive baboon is a suitable model for biogerontology research, immune senescence, and development of vaccines. Though there are phenotypic and functional similarities between baboons and humans, specific differences exist in immune cell expression and immune function of lymphocytes that should be considered for better experimental outcomes in the development of therapeutics and restoring innate and adaptive immune function in aged individuals.
Case Report: Targeted plasticity in spinal cord injury—the role of focal muscle vibration and neurocognitive rehabilitation in adaptative synaptic change along sensory and motor circuit
Authors: Camerota Filippo , Pocino Naomi Francesca , Zangrando Federico , Di Tommaso Roberta , Paoloni Marco , Mangone Massimiliano , Celletti Claudia 
Published: January 2025

PurposeThe purpose of this case was to investigate objectively and quantitatively the effects of the application of repeated focal muscle vibration (fMV) associated with neurocognitive exercise on a 46-year-old patient with spastic paraparesis secondary to the surgical removal of a C5–C6 ependymoma.MethodsWe have evaluated gait parameters, spasticity, and pain with clinical scales. We have applied focal muscle vibration on quadriceps femoris, hamstrings, gastrocnemius, and iliopsoas muscles bilaterally. A total of 30 sessions of fMV treatment of 80 min each was carried out over 30 consecutive days.ResultsAfter the whole treatment period, the patient showed an overall improvement in scores on the same assessment scales administered at admission. The gait analysis evaluation showed a reduction in stride time bilaterally, an increase in average walking speed, increased cadence, and a slight increase in step length.ConclusionThe improvements obtained have highlighted the relevance of the fMV application associated to physiotherapy in the field of neurological rehabilitation, particularly emphasizing the interest in increasing the number of sessions correlated with more durable clinical improvements over time. Results obtained have shown to persist for several months after discharge, allowing the patient to improve walking and to have greater autonomy in daily activities.
Content and face validity in virtual reality with children: a validation in five steps+1 of a wheelchair basketball game
Authors: Ceberio Imanol , Al-Rashaida Mohammad , García Maitane , Lopez Paz Juan Francisco , Salgueiro Monika , Passi Nicole , Pavel Humberto , Amayra Imanol 
Published: January 2025

ObjectiveThe present study is aimed to elaborate and determinate the content and face validity of a virtual reality program attending the perspective of children. This simulation is designed to promote empathy and understanding towards children with motor disabilities through adapted sport scenes. This study proposed a validation approach with six phases to assess technical and aesthetic aspects.MethodSample: a) Content validity study, 20 children (11–18 years old) were recruited as lay and content experts, who assessed the properties of grade of realism and physical fidelity of wheelchair basketball scenarios. b) Face validity study, 395 children were recruited as lay experts and divided into two groups (7–9 years old and 10–12 years old), or into ten subgroups according to Age × Gender interaction. The face validity sample assessed the psychological fidelity and the presence of wheelchair basketball scenarios. Instruments: Virtual Reality Content Validity Questionnaire, GAMEX questionnaire and Simulator Sickness Questionnaire (SSQ).ResultsThe content validity study showed preference for technical aspects (music, colors and degree of realism). Therefore, modifications in the design were made. In the content validity study, the high agreement level was influenced by previous sport experiences. In the face validity study, the cognitive development of children determined the differences in agreement levels in some virtual properties (absorption and cybersickness). In this sixth step, the ages 7–8 years versus 10–11 years showed significant differences in validity. The study also criticized the face validity cut-offs often used in adult-focused research, emphasizing the need to adapt them for children´s developmental stages.ConclusionThis study proposes a sixth step not traditionally included in content and face validity processes, specially focusing on the child user. The suitability of content and scenes should follow the same principles of standardization as other methodologies, such as psychometric tests, considering age and gender.
Identifying strokes in Nigerian children with sickle cell disease as part of clinical trials: training curriculum for healthcare professionals in low-income settings
Authors: Ghafuri Djamila L. , Bello-Manga Halima , Kirkham Fenella J. , Ciobanu Mariana , Trevathan Edwin , Rodeghier Mark , DeBaun Michael R. , Jordan Lori C. 
Published: January 2025

IntroductionNigeria has the highest proportion of children with sickle cell anemia (SCA) globally; without transcranial Doppler screening and ongoing treatment (regular blood transfusions or hydroxyurea therapy), 10% will have a stroke in childhood. In low-resource settings, training to recognize and prevent strokes in children with SCA is vital. A sustainable Sickle Cell Disease Stroke Prevention Teams program was established, as part of clinical trials, to address the need for stroke care in northern Nigeria. We describe our health professional stroke training curriculum and specific application to detect strokes in clinical trials in low-resource settings.MethodsChildren aged 5–12 and 2–16 years with SCA in northern Nigeria were enrolled in the SPRING and SPRINT primary and secondary stroke prevention trials, respectively. The primary outcome measure in both trials was a clinical stroke based on the World Health Organization definition. Non-neurologist physicians were trained in-person and via video lectures regarding stroke recognition, performing neurological examinations using the adapted Pediatric NIH Stroke Scale, and acute stroke care. Central stroke adjudicators, two pediatric neurologists, reviewed the case report forms and recorded videos of the neurological examinations.ResultsSix physicians completed the curriculum at three sites and were certified to detect strokes. Of 20 children with suspected stroke, 8 and 11 children had acute initial or acute recurrent strokes confirmed in the SPRING (N = 220) and SPRINT (N = 101) trials, respectively. The concordance rate between local stroke diagnoses and the central stroke adjudication process was 95% (19 of 20). One child presented with non-specific symptoms and hypertonia and was mislabeled locally as an acute stroke.DiscussionA curriculum to train healthcare providers in pediatric acute stroke recognition and care in a low-resource setting is feasible and sustainable. We successfully identified strategies for task shifting from a single pediatric neurologist in the region to multiple non-neurologist physicians.
MRI to digital medicine diagnosis: integrating deep learning into clinical decision-making for lumbar degenerative diseases
Authors: Ke Baoyi , Ma Wenyu , Xuan Junbo , Liang Yinghao , Zhou Liguang , Jiang Wenyong , Lin Jing , Li Guixiang 
Published: January 2025

IntroductionTo develop an intelligent system based on artificial intelligence (AI) deep learning algorithms using deep learning tools, aiming to assist in the diagnosis of lumbar degenerative diseases by identifying lumbar spine magnetic resonance images (MRI) and improve the clinical efficiency of physicians.MethodsThe PP-YOLOv2 algorithm, a deep learning technique, was used to design a deep learning program capable of automatically identifying the spinal diseases (lumbar disc herniation or lumbar spondylolisthesis) based on the lumbar spine MR images. A retrospective analysis was conducted on lumbar spine MR images of patients who visited our hospital from January 2017 to January 2022. The collected images were divided into a training set and a testing set. The training set images were used to establish and validate the deep learning program's algorithm. The testing set images were annotated, and the experimental results were recorded by three spinal specialists. The training set images were also validated using the deep learning program, and the experimental results were recorded. Finally, a comparison of the accuracy of the deep learning algorithm and that of spinal surgeons was performed to determine the clinical usability of deep learning technology based on the PP-YOLOv2 algorithm. A total of 654 patients were included in the final study, with 604 cases in the training set and 50 cases in the testing set.ResultsThe mean average precision (mAP) value of the deep learning algorithm reached 90.08% based on the PP-YOLOv2 algorithm. Through classification of the testing set, the deep learning algorithm showed higher sensitivity, specificity, and accuracy in diagnosing lumbar spine MR images compared to manual identification. Additionally, the testing time of the deep learning program was significantly shorter than that of manual identification, and the differences were statistically significant (P &lt; 0.05).ConclusionsDeep learning technology based on the PP-YOLOv2 algorithm can be used to identify normal intervertebral discs, lumbar disc herniation, and lumbar spondylolisthesis from lumbar MRI images. Its diagnostic performance is significantly higher than that of most spinal surgeons and can be practically applied in clinical settings.
DIGITAL APPLICATION FOR LIFESTYLE PROMOTION IN PREDIABETES MANAGEMENT: A CASE STUDY IN BANDUNG CITY
Authors: Setiawan Ridwan - , Karjatin Atin , Herdhianta Dhimas 
Published: January 2025

Background: Prediabetes is a condition where blood glucose levels are elevated but not high enough to be classified as diabetes. This condition is a significant global health challenge, especially in urban areas like Bandung. Effective prevention relies on lifestyle changes, which can be supported through accessible digital applications.
Objectives: To develop an accurate digital app model to support lifestyle changes in prediabetes and be able to differentiate well between various user groups.
Method: Data were collected from respondents regarding age, diabetes history, daily activity, and Body Mass Index (BMI). The model's effectiveness was assessed using Omnibus Tests of Model Coefficients, with accuracy evaluated through the Likelihood Ratio Test and ROC Curve analysis.
Results: The majority of respondents were under 45 years of old (88.1%) and female (72.2%). Most had no diabetes history (92.1%) and were active daily (71.4%), with normal BMI in 57.9% of participants. Model testing revealed significant outcomes, with a p-value of 0.00 and an Asymptotic Significance of 0.006, alongside a likelihood ratio value of 81.962, underscoring the model’s accuracy and reliability.
Conclusion: The developed digital application is both accurate and reliable for promoting lifestyle changes in prediabetes.
Correlative behavior between defect generation and ferroelectricity development in Hf0.5Zr0.5O2
Authors: Morita Yukinori , Asanuma Shutaro , Ota Hiroyuki , Migita Shinji 
Published: January 2025

Abstract
Using electrical measurements and analysis, we investigated the relationship between the generation of defects in pristine Hf0.5Zr0.5O2 (HZO) metal-ferroelectric-metal (MFM) capacitor and their ferroelectricity. Applying a voltage to the HZO MFM capacitor for the first time, its current characteristics showed anomalous features, which differed from the typical ferroelectric characteristics observed in the second voltage application. In our previous research, we proposed the origin of this phenomenon as the generation of electric-field-induced defects in the HZO film, which mediated the current flowing through the MFM capacitor. In the present research, as a result of precise measurements of current–voltage characteristics, it was found that the defect density generated depended on the maximum electric field strength applied to the MFM. Similarly, with increasing defects, the ferroelectricity of the HZO was emphasized. Based on this relationship, we proposed a model in which electric field-induced defect generation initiated ferroelectric transformation in the HZO layer.
Value Chain Development of Mamberamo Rice in Oe-Cusse-Timor Leste for Economic Sustainability
Authors: Dos Santos Joni Maria , Soewignyo Tonny Irianto 
Published: January 2025

Mamberamo rice value chain development towards economic sustainability in Oé-cusse Timor Leste. The research used descriptive and qualitative methods with a structured interview approach based on the prepared questionnaire. Main target of the research is rice farmers who have access to the agricultural land with a sample taken of 45 people. The sampling method randomly selected from 4 agricultural areas in Pante Makassar such as Costa, Lalicuk, Cunha and Lifau in which 5 representatives/ 100 ha selected for each area. The purpose of this research is to find out: (1) What are the current problems faced by the farmer related to the technologies and adoption of technologies to increase production? (2) What are the current problems faced by the farmer related to the storage system, processing, and marketing of Memberamo rice? The results of the study found that 36% of farmers answered that the problem they often faced was a lack of knowledge of technology to increase rice production, and 100% of farmers used inorganic fertilizers however 91% said it was very expensive. According to the result, after harvest, 98% of farmers prefer to store it at home, without temperature settings. In the Market Access variable, it was found that 87% of farmers found it difficult to bring their products to both local and national markets. Meanwhile, 56% of farmers answered that it was very difficult to access the market. Another finding is about the way they sell their products to the market – 78% of respondents sold their products without proper packaging.

Keywords: Economic Sustainability, Mamberamo Rice, Market Access, Value Chain
Assessment of the correlation of lipasin levels with HOMA-IR score as an index of insulin resistance in type 2 diabetic Iraqi patients
Authors: Seenaa B. Mohammed  , Alaa. J. Mahrath  , Tariq. R. Abd  
Published: January 2025

Lipasin, a hormone found in the liver and adipose tissue, is involved in glucose homeostasis and lipid metabolism. Lipasin levels in plasma are controlled by food and rise after glucose consumption. Because plasma glucose and insulin levels both rise after eating, The study aims to elucidate if lipasin increases insulin sensitivity.
According to this study, the patient group's lipasin concentration increased significantly (p-value˂ 0.05) in comparison to the control group, and the area under the curve (AUC) for lipasin was 75.75 %.
The levels of insulin and glucose and also for the BMI were higher (p-value˂ 0.05) in patient group in comparison to control group.
The results emphasize that Lipasin may play a crucial role in T2DM development.
A Crescente Incidência de Câncer de Pele Não Melanoma no estado de Santa Catarina entre 2014 e 2024 – Um Estudo Epidemiológico
Authors: Freitas Leitão Gudwin Júlia , Cestari Matheus , De Biasio Milano Eduardo , Cristina Capelli Carolinne 
Published: January 2025

O câncer de pele não melanoma (CPNM) é a neoplasia cutânea mais prevalente no Brasil, apresentando uma taxa de incidência em ascensão no estado de Santa Catarina ao longo da última década. Este artigo tem por objetivo analisar o perfil epidemiológico do CPNM no estado nos últimos dez anos identificando as faixas etárias mais afetadas, os tipos de CPNM mais prevalentes, os principais fatores de risco e as cidades mais incidentes, propondo estratégias de enfrentamento desse cenário. Foi realizada uma revisão sistemática de literatura com análise de dados secundários obtidos do Sistema de Informações sobre Mortalidade (SIM) e do Sistema de Informações Hospitalares (SIH), ambos disponibilizados pelo DATASUS. A pesquisa incluiu artigos indexados com dados de incidência e mortalidade por CPNM, estratificados por faixa etária, sexo e município, no período de 2014 a 2024. O estudo identificou que o principal tipo de CPNM foi o Carcinoma Basocelular (CBC) na faixa etária entre os 50-69 anos. As cidades de Florianópolis, Joinville e Blumenau destacaram-se entre as mais acometidas. A exposição solar em excesso foi o fator de risco com maior aumento percentual no período estudado. O aumento da incidência foi atribuído a maior conscientização sobre a doença e ao envelhecimento populacional. As conclusões sugerem que estratégias de educação em saúde, prevenção e diagnóstico precoce são fundamentais para reduzir a mortalidade e melhorar a qualidade de vida dos pacientes.
Modeling the Causal Structural Relationship Between Test Wisdom, Cognitive Load, and Academic Achievement Among University Students
Authors: AL-Nasraween Moen Salman , AL-Karamneh Mohammad , Alsoudi Sharif 
Published: January 2025

The study aimed to investigate the causal structural relationship between test wisdom, cognitive load, and academic achievement for university students. The descriptive correlational survey approach was adopted. The researchers developed two scales, namely the test wisdom scale and the cognitive load scale. Their psychometric properties were verified before being applied to the main study sample, which consisted of 422 male and female university students selected via the proportional stratified random sampling. The results showed that the level of cognitive load was high, and the level of test wisdom was moderate. The results also showed that there were positive and statistically significant correlations between cognitive load, academic achievement, and test wisdom. The study also showed a direct effect between test wisdom with academic achievement, and cognitive load with academic achievement. In light of the study results, a set of recommendations were proposed perhaps the most important of which is paying attention to reducing the cognitive load of university students and working to improve the students' test wisdom.

Received: 3 October 2024 / Accepted: 28 December 2024 / Published: 05 January 2025
Factors Influencing the Development of Digital Competencies in Higher Education Teachers in Latin America: A Systematic Review
Authors: Ramírez Heredia Rosa Candelaria , Franco Lazarte Erick Giovanni , Carcausto-Calla Wilfredo 
Published: January 2025

In the present work, the objective was to perform a systematic review of the literature on the main aspects related to the factors that influence the development of digital competencies in university teachers (DTC) in Latin America, published in the last 5 years, corresponding to 2020 to 2024. The review was carried out taking into account the suggested methodological guidelines, using search strategies in different databases. Scopus, Scielo, and Web of Science. The results obtained reveal the existence of factors related to the development of the DTC, these factors are sociodemographic and institutional, with the following variables: age group, gender, length of service and institutional policies, educational management, technological infrastructure and training, respectively. It is concluded that there are sociodemographic and institutional factors that play an important role in the development of the digital competencies and that it is crucial to know them for the appropriate use of strategies aimed at promoting a digital transformation in teachers, thus improving pedagogical practices.

Received: 8 September 2024 / Accepted: 20 December 2024 / Published: 05 January 2025