bluuebunny/crossref_metadata_2025_split huggingface dataset:
Websites or Videos: Which Offer Better Information for Patients? A Comparative Analysis of the Quality of YouTube Videos and Websites for Cosmetic Injectables
Authors: Patel Anooj A. , Mulvihill Lianne , Jin Alison , Patel Ashit , Galiano Robert D. 
Published: January 2022

Background:
YouTube is used by more than 70 percent of adults and 81 percent of 15- to 25-year-olds. The information quality of videos related to the two most performed aesthetic procedures—botulinum toxin type A (Botox) and soft-tissue filler injections—has not been assessed or compared to that of websites.

Methods:
A YouTube search for “Botox” and “fillers” was performed in July of 2020, identifying the most popular health information videos. Quality was assessed using the validated Journal of American Medical Association, Health on the Net principles, and the DISCERN criteria in addition to a procedure-specific content score. Quality scores were compared between different groups of video contributors and against websites.

Results:
A total of 720 measurements of quality were performed across 95 YouTube videos and 85 websites. The mean quality scores were as follows: Journal of the American Medical Association, 1.74/4 ± 0.718; Health on the Net, 6.66/16 ± 2.07; DISCERN, 40.0/80 ± 9.25; and content, 39.1/100 ± 11.9. Physician, nonphysician health professionals, and other (news, magazine channels, and influencers) were all of higher quality than patient-based videos (p < 0.001). The mean DISCERN percentage score for videos was 50.04 ± 11.57 and significantly less than that of websites, 55.46 ± 15.74 (p = 0.010). The mean content scores showed a similar result, 39.06 ± 11.92 versus 60.76 ± 17.65 (p < 0.001), respectively.

Conclusions:
Improvement is needed in the quality of YouTube videos related to aesthetic injectables. Plastic surgeons, who are the most frequent video contributors, are most qualified to provide this change. Plastic surgeons should include videos as part of their online presence, as they may help facilitate a greater viewership.
68Ga–Prostate-Specific Membrane Antigen–Avid Malignant Pleural Effusion in a Patient With Metastatic Adenoid Cystic Carcinoma and Concordance With 18F-FDG PET/CT
Authors: Uijen Maike José Maria , Weijers Jetty Anne Mina , Driessen Chantal Maria Leonarda , van Herpen Carla Marie Louise , Nagarajah James 
Published: January 2022

Abstract
Adenoid cystic carcinoma (ACC) is a rare cancer that arises from salivary glands and other secretory glands. Pulmonary metastases are frequently observed in ACC patients with metastatic disease. Previous research showed that ACC often shows high PSMA uptake on 68Ga-PSMA-11 PET/CT. Here, we present PET images from an ACC patient with pulmonal, pleural metastases, and malignant pleural effusion, with comparable tracer uptake on 68Ga-PSMA-11 PET and 18F-FDG PET.
Paraneoplastic Cerebellar Syndrome Presented as Cerebellar Hypermetabolism in a Patient With Occult Breast Carcinoma
Authors: Booij Jan , Adam Judit A. , van Eerde Maaike S. , Bronner Irene M. 
Published: January 2022

Abstract
A 47-year-old woman presented with an acute cerebellar syndrome. Neither cerebellar atrophy nor an infarction or tumor was shown on MRI. A diagnostic CT demonstrated enlarged axillary lymph nodes, but no primary tumor. Puncture of these nodes showed non–small cell carcinoma. 18F-FDG PET/CT imaging was performed and suggested an occult breast carcinoma, which was confirmed by pathological examination. It also showed cerebellar hypermetabolism, consistent with a PCS (paraneoplastic cerebellar syndrome). This case shows that 18F-FDG PET imaging may be of value in patients in which a PCS is considered clinically, particularly in patients suspicious for an occult malignancy.
Clinical and Sonographic Features of Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features
Authors: Ni Xiaofeng , Xu Shangyan , Zhang Benyan , Zhan Weiwei , Zhou Wei 
Published: January 2022

Abstract
This study was designed to investigate the clinical and sonographic features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTPs) as compared with classical papillary thyroid carcinoma (cPTC), follicular adenoma (FA), and follicular thyroid carcinoma (FTC). A total of 178 patients were enrolled in this study. The clinical characteristics and sonographic features of thyroid nodules were compared between NIFTP and cPTC or FA/FTC. All nodules were reclassified according to the Thyroid Ultrasound Imaging Reporting and Data System and American Thyroid Association guidelines classification. The mean size of NIFTP was 29.91 ± 14.71 mm, which was larger than that of cPTC (P = 0.000). Significant difference was found in lymph node metastases between NIFTP and cPTC (P = 0.000). Most NIFTPs showed solid composition, hypoechoic echogenicity, smooth margin, wider than tall shape, none echogenic foci, absence of halo, and perinodular vascularity, which were similar with FA and FTC. Compared with NIFTP, hypoechoic and very hypoechoic, taller than wide, irregular margin, punctate echogenic foci, absence of halo, and low vascularity were more commonly observed in cPTC. There were statistical differences both in American College of Radiology Thyroid Ultrasound Imaging Reporting and Data System and in American Thyroid Association classification between NIFTP and cPTC (P < 0.05), but there were no significant differences between NIFTP and FTC/FA (P > 0.05). The ultrasonographic characteristics of NIFTP were obviously different from cPTC but overlapped with FTC and FA. Ultrasound could help increase preoperative attention of NIFTP in an appropriate clinical setting, which may lead to a more conservative treatment approach.
Balloons for kids: Anatomic candidacy and optimal catheter size for pediatric resuscitative endovascular balloon occlusion of the aorta
Authors: Sykes Alicia Gaidry , Sisson William B. , Wang Lucas J. , Martin Matthew J. , Thangarajah Hariharan , Naheedy John , Fernandez Nathanial , Nelles Meghan E. , Ignacio Romeo C. 
Published: January 2022

BACKGROUND
Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a potential adjunct in pediatric trauma patients with noncompressible truncal and pelvic hemorrhage; however, there are little data evaluating the anatomic considerations of REBOA in children. We evaluated the vascular dimensions and anatomic limitations of using REBOA in children.

METHODS
Computed tomography scans of pediatric patients performed between February 2016 and October 2019 were retrospectively reviewed by two investigators. Vascular measurements included diameters of aorta zones I and III, common iliac arteries, external iliac arteries, and common femoral arteries (CFAs), and distances between access site (CFA) and aorta zones I and III. Measurements were grouped within Broselow categories, based upon patient height. Interrater reliability for measurements was determined using intraclass correlation coefficients. Vascular dimensions were correlated with the patient's height, weight, and body mass index using linear regression analysis.

RESULTS
A total of 557 computed tomography scans met the inclusion criteria and were reviewed. Measurements of vessel diameter and distance from the CFA to aorta zones I and III were determined and grouped by Broselow category. Patient age ranged from 0 to 18 years, with a male to female ratio of 1:1. Overall interrater reliability of vessel measurements was good (average intraclass correlation coefficient, 0.90). Vessel diameter had greatest correlation with height (R
2 = 0.665, aorta zone I; R
2 = 0.611, aorta zone III) and poorly correlated with body mass index (R
2 = 0.318 and R
2 = 0.290, respectively).

CONCLUSION
This study represents the largest compilation of REBOA-related pediatric vessel diameter measurements and the first to provide data on distance between access site and balloon deployment zones. Based on our findings, the 7-Fr REBOA catheter would be appropriate for the Black, Green, and Orange Broselow categories, and a 4-Fr REBOA catheter would be warranted for Yellow, White, and Blue Broselow categories.

LEVEL OF EVIDENCE
Prognostic and epidemiological, level III.
Neoantigen Landscape Supports Feasibility of Personalized Cancer Vaccine for Follicular Lymphoma
Authors: Ramirez Cody A. , Frenkel Felix , Becker-Hapak Michelle , Barnell Erica K. , McClain Ethan D. , Desai Sweta , Schappe Timothy , Onyeador Onyinyechi C. , Kudryashova Olga , Belousov Vladislav , Bagaev Alexander , Ocheredko Elena , Kiwala Susanna , Hundal Jasreet , Skidmore Zachary L. , Watkins Marcus P. , Mooney Thomas B. , Walker Jason R. , Krysiak Kilannin , Russler-Germain David A. , Gomez Felicia , Fronick Catrina C. , Fulton Robert S. , Schreiber Robert D. , Mehta-Shah Neha , Cashen Amanda F. , Kahl Brad S. , Ataullakhanov Ravshan , Bartlett Nancy L. , Griffith Malachi , Griffith Obi L. , Fehniger Todd A. 
Published: January 2022

AbstractPersonalized cancer vaccines designed to target neoantigens represent a promising new treatment paradigm in oncology. In contrast to classical idiotype vaccines, we hypothesized that ‘polyvalent’ vaccines could be engineered for the personalized treatment of follicular lymphoma (FL) using neoantigen discovery by combined whole exome sequencing (WES) and RNA sequencing (RNA-Seq). Fifty-eight tumor samples from 57 patients with FL underwent WES and RNA-Seq. Somatic and B-cell clonotype neoantigens were predicted and filtered to identify high-quality neoantigens. B-cell clonality was determined by alignment of B-cell receptor (BCR) CDR3 regions from RNA-Seq data, grouping at the protein level, and comparison to the BCR repertoire of RNA-Seq data from healthy individuals. An average of 52 somatic mutations per patient (range: 2-172) were identified, and two or more (median: 15) high-quality neoantigens were predicted for 56 of 58 samples. The predicted neoantigen peptides were composed of missense mutations (76%), indels (9%), gene fusions (3%), and BCR sequences (11%). Building off of these preclinical analyses, we initiated a pilot clinical trial using personalized neoantigen vaccination combined with PD-1 blockade in patients with relapsed or refractory FL (#NCT03121677). Synthetic long peptide (SLP) vaccines were successfully synthesized for and administered to all four patients enrolled to date. Initial results demonstrate feasibility, safety, and potential immunologic and clinical responses. Our study suggests that a genomics-driven personalized cancer vaccine strategy is feasible for patients with FL, and this may overcome prior challenges in the field.
Egg-derived anti-SARS-CoV-2 immunoglobulin Y (IgY) with broad variant activity as intranasal prophylaxis against COVID-19
Authors: Frumkin Lyn R. , Lucas Michaela , Scribner Curtis L. , Ortega-Heinly Nastassja , Rogers Jayden , Yin Gang , Hallam Trevor J , Yam Alice , Bedard Kristin , Begley Rebecca , Cohen Courtney A. , Badger Catherine V. , Abbasi Shawn A. , Dye John M. , McMillan Brian , Wallach Michael , Bricker Traci L. , Joshi Astha , Boon Adrianus C.M. , Pokhrel Suman , Kraemer Benjamin R. , Lee Lucia , Kargotich Stephen , Agogiya Mahima , St. John Tom , Mochly-Rosen Daria 
Published: January 2022

ABSTRACTCOVID-19 emergency use authorizations and approvals for vaccines were achieved in record time. However, there remains a need to develop additional safe, effective, easy-to-produce, and inexpensive prevention to reduce the risk of acquiring SARS-CoV-2 infection. This need is due to difficulties in vaccine manufacturing and distribution, vaccine hesitancy, and, critically, the increased prevalence of SARS-CoV-2 variants with greater contagiousness or reduced sensitivity to immunity. Antibodies from eggs of hens (immunoglobulin Y; IgY) that were administered receptor-binding domain (RBD) of the SARS-CoV-2 spike protein were developed as nasal drops to capture the virus on the nasal mucosa. Although initially raised against the 2019 novel coronavirus index strain (2019- nCoV), these anti-SARS-CoV-2 RBD IgY surprisingly had indistinguishable enzyme-linked immunosorbent assay binding against variants of concern that have emerged, including Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2), and Omicron (B.1.1.529). This is distinct for sera from immunized or convalescent patients. Culture neutralization titers against available Alpha, Beta, and Delta were also indistinguishable from the index SARS-CoV-2 strain. Efforts to develop these IgY for clinical use demonstrated that the intranasal anti-SARS-CoV-2 RBD IgY preparation showed no binding (cross-reactivity) to a variety of human tissues and had an excellent safety profile in rats following 28-day intranasal delivery of the formulated IgY. A double-blind, randomized, placebo- controlled phase 1 study evaluating single-ascending and multiple doses of anti-SARS-CoV-2 RBD IgY administered intranasally for 14 days in 48 healthy adults also demonstrated an excellent safety and tolerability profile, and no evidence of systemic absorption. As these antiviral IgY have broad selectivity against many variants of concern, are fast to produce, and are a low-cost product, their use as prophylaxis to reduce SARS-CoV-2 viral transmission warrants further evaluation. (ClinicalTrials.gov: NCT04567810, https://www.clinicaltrials.gov/ct2/show/NCT04567810)
Computer adaptive testing to assess impairing behavioral health problems in emergency department patients
Authors: O’Reilly Lauren M. , Dalal Azhar I. , Maag Serena , Perry Matthew T. , Card Alex , Bohrer Max B. , Hamersly Jackson , Mohammed Setarah , Peterson Kelli , Beiser David G. , Gibbons Robert D. , D’Onofrio Brian M. , Musey Paul I. 
Published: January 2022

AbstractStudy ObjectiveTo assess the prevalence of several impairing behavioral health domains in stable patients presenting to the emergency department (ED) through the use of computer adaptive testing and the association among the domains, standard assessments, and ED utilization.MethodsThis was a single-center observational study of 828 randomly selected adult patients presenting to the ED from May 2019 to March 2020. The main outcomes of interest were the self-administered, validated computer adaptive assessments of suicidality, depression, anxiety, PTSD, and substance abuse using computer adaptive testing, the CAT-MH™. We estimated the association among the CAT-MH™ subscales, standard assessments, and the number of ED visits in the year prior and 30 days after enrollment.ResultsThe proportion of those who scored above the threshold of low/mild risk were: 24.1% (suicidality), 8.3% (depression), 16.5% (anxiety), 12.3% (PTSD), and 20.4% (substance use). While the CAT-MH™ subscales were highly correlated with other self-report assessments, they were not highly associated with standard ED assessments of suicidality. When examining associations with ED use, for example, individuals who had two or more ED visits in the prior year had 51% increased odds of being in the intermediate-high suicide risk category (95% Confidence Interval [CI], 1.03-2.23) compared to those with zero prior ED visits.ConclusionThe CAT-MH™ can document the high prevalence of mental health conditions in the ED, which were missed by standard ED practices. Mental health problems are associated with ED utilization in a population of patients presenting largely for somatic complaints.
Potential uses of AI for perioperative nursing handoffs: a qualitative study
Authors: King Christopher Ryan , Shambe Ayanna , Abraham Joanna 
Published: January 2022

ABSTRACTObjectiveSituational awareness and anticipatory guidance for nurses receiving a patient after surgery are key to patient safety. Little work has defined the role of artificial intelligence (AI) to support these functions during nursing handoff communication or patient assessment. We used interviews and direct observations to better understand how AI could work in this context.Materials and Methods58 handoffs were observed of patients entering and leaving the post- anesthesia care unit at a single center. 11 nurses participated in semi-structured interviews. Mixed inductive-deductive thematic analysis extracted major themes and subthemes around roles for AI supporting postoperative nursing.ResultsFour themes emerged from the interviews: (1) Nurse understanding of patient condition guides care decisions, (2) Handoffs are important to nurse situational awareness; problem focus and information transfer may be improved by AI, (3) AI may augment nurse care decision making and team communication, (4) User experience and information overload are likely barriers to using AI. Key subthemes included that AI-identified problems would be discussed at handoff and team communications, that AI-estimated elevated risks would trigger patient re- evaluation, and that AI-identified important data may be a valuable addition to nursing assessment.Discussion and ConclusionMost research on postoperative handoff communication relies on structured checklists. Our results suggest that properly designed AI tools might facilitate postoperative handoff communication for nurses by identifying elevated risks faced by a specific patient, triggering discussion on those topics.LAY SUMMARYNurses caring for patients after surgery make many decisions about what complications to look for and how to treat issues that arise. They rely on handoffs from prior providers to understand the patient’s background, events, and plans so far. We observed nurse handoffs after surgery where operating room nurses transfer information and their care responsibility to postoperative unit nurses to ensure care continuity. We also interviewed nurses to ask if and how artificial intelligence (AI) might help them focus their handoff communication on likely problems and generally understand the patient. Our participants stated that if AI identified likely issues, they would discuss those topics in handoff, communicate about those problems with physicians, and modify their monitoring and treatment to the level of risk faced by the patient. This finding runs against most research on improving communication, which focuses on checklists of topics to discuss. Most uses of AI for nurses focus on making specific to-do recommendations and documentation reminders and search, but we find that nurses would benefit from AI which focuses more on their understanding of the patient’s condition. These findings have major implications for the application of AI support for nurses.
Effect of photovoltaic installation power and façade glazing ratio on the energy performance of a nursery building
Authors: Marchwiński Janusz , Kurtz-Orecka Karolina 
Published: January 2022

PurposeThe aim of the research is to determine the influence of photovoltaic (PV) installation and the share of façade glazing on the energy profile of nursery buildings in the Baltic Sea region, as well as defining the most favorable configuration in terms of energy efficiency.Design/methodology/approachThe article provides comparative calculations of energy performance indicators (Ep, Ed, Eu) and CO2 emissions (mCO2) made for the defined model of the nursery. It includes calculations concerning energy performance of the building, depending on its PV power (0–60 kWp), PV efficiency (100 and 85%) and façade glazing ratio (GR = 25%, 50% and 75%).FindingsThe results of the research indicate that an increase in the PV power exerts proportional impact on the reduction of the Ep and Ed indicators, as well as on the CO2 emissions. Only low GR values (25%) reduce the Eu indicator significantly. Decrease in high range of GR values (over 50%) does not provide proportional effects. In the variant: 60 kWp (100% efficiency) with GR = 25%, the biggest share (99.5%) of RES was obtained. This proves that the concept of energy independent nursery buildings is feasible and reasonable in the examined location.Practical implicationsDesigning buildings towards environmental neutrality requires laborious pre-design conceptual work before developing the right solutions. The set of results of the relationship between the variables of the building's envelope, energy performance indicators and the required involvement of active RES installations to achieve high energy performance of a building presented in the article is valuable. It allows for a preliminary decision of the direction of the design solutions selection in the design process of public utility buildings, such as nurseries. Thus, it may significantly shorten the pre-design analysis process for the location of the southern part of the Baltic Sea region.Originality/valueThe novelty of the paper relies on examining the dependences between PV power and façade glazing ratio in terms of their influence on energy profile of nursery buildings.
Robotics at dimension data: friend or foe of the human in process automation?
Authors: Karim Michelle , Swart-Opperman Christina , Bick Geoff 
Published: January 2022

Learning outcomes
The learning outcomes are follows: critically assess the impact of disruptive technologies, such as automation, on the organisation, its processes and employees; evaluate the structural changes required within the organisation to prepare for digital transformation; apply change models to the unique challenges associated with disruptive technologies; and recommend solutions for the organisation to proceed with the implementation of disruptive technologies, while keeping employees central to the change.

Case overview/synopsis
The Dimension Data automation case provides students and executives with a glimpse of the future that organisations and employees must prepare for. The case starts out with the protagonist and product owner of digital at Dimension Data, Andrew Harmse, reflecting on his three-year automation journey within the Automation Centre of Excellence. The world of automation is growing exponentially, and Andrew’s team will have to support the organisation as they scale up their automation journey and navigate the uncertain future of an increased, blended human-robot workforce. Individual employee reactions, positive and negative, will have to be balanced with the opportunities that ever-changing technology enables. The case focusses on the themes of digital transformation, digital disruption, change management and the very real factors to consider when faced with decision-making on automation as the world is constantly changing. The COVID-19 pandemic has forced organisations to relook processes and increase investment in technologies that enable digital client engagement and servicing, considering social distancing requirements. Automation at dimension data has been largely internally focussed, but there is a drive to increase delivery for clients. Andrew’s team will have to guide organisations through the journey and continuum of changes and uncertainties, such as large- scale unemployment and robot ethics.

Complexity academic level
The target audience for this teaching case are postgraduate and Master level students, specifically Master of Business Administration (MBA) students as well as Executive Education courses. Students who are responsible for making strategic decisions that impact the future of their organisations as well as students with an interest in the role of technology in the future will benefit from the case.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 6: Human Resource Management.