bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parents' experiencees of life after medicalised conception: A systematic review and thematic meta-synthesis
Authors: Foyston Zoe , Higgins Lucy , Smith Debbie , Wittkowski Anja 
Published: October 2022

Abstract
Background: Medicalised Conception (MAC) assists many couples to achieve pregnancy worldwide. As the impact of MAC has been linked to increased pregnancy-specific anxiety and parenting difficulties, this review aimed to explore parental experiences of pregnancy and early parenting following MAC, identifying their psychological, social and health needs.
Method: Five databases were searched systematically. Identified articles were screened for eligibility. Twenty qualitative studies met inclusion criteria and results were analysed using thematic synthesis. The Critical Appraisal Skills checklist was employed to appraise methodological quality.
Results: The findings were synthesised into three main themes: 1) The vulnerable parent: fear, doubt, uncertainty, 2) the stark realisation of the parental dream, 3) psychosocial needs and support. Parents lacked a sense of safety during pregnancy and acted protectively, both antenatally and postnatally. Identity transition was complex and non-linear, influenced by sociocultural context.
Conclusions: Considerable unmet psychosocial needs were identified with a need for consistent, holistic care, integrating psychological services.
Early detection of chronic kidney disease in a diabetic population. A massive screening program in primary healthcare in a middle-income country
Authors: Miguel Mejía-Arias , Lastiri-Quirós H. Santiago , Obrador Gregorio T. , Palacio-Mejía Lina Sofía , Hernández-Avila Juan Eugenio , Amezcua Mario Márquez , Tamayo-Ortiz Marcela , Alvarez-Aceves Mariana , Guzmán-Sandoval Leslie , Hernández-Avila Mauricio , Tamayo-Orozco Juan Alfredo 
Published: October 2022

Abstract
Background
Early detection of chronic kidney disease (CKD) allows health professionals and patients to take actions to slow physical impairment and prevent or delay dialysis or transplantation and their catastrophic costs. In this study, we aimed to describe a CKD massive screening program in patients with diabetes to explore the feasibility of massive detection of CKD in high-risk patients.
Methods
We performed a descriptive, cross-sectional study with people living with diabetes, at the primary healthcare units of the Ministry of Health in Jalisco, Mexico. They underwent a screening including a health history questionnaire, somatometry, urinary albumin, serum creatinine, and estimated glomerular filtration rate (eGFR) in accordance with the Kidney Early Evaluation Program (KEEP). We described demographic and clinical characteristics of the population by sex and calculated the prevalence of each CKD stage.
Results
Of 7,693 recruited patients, 44% were identified with CKD; 35% were in early stages (1 or 2), and 9% in stages 3 to 5. Less than 1% of total patients had previous CKD diagnosis. Among other clinical characteristics, we found that 83% of all patients were overweight or obese and 79% had blood pressure values over 130/80 mmHg.
Conclusions
This study shows the technical feasibility and usefulness of massive CKD screening campaigns in high-risk people at primary healthcare services. Patients with renal function impairment, who require treatment for preventing disease progression, were identified. It is essential to formulate public policies aimed at protocolization of timely medical interventions to address the incidence and prevalence of CKD.
Numerical Simulations of Dynamic Replacement Method in Clay Lateritic Soils
Authors: de Souza Tennison Freire , Heineck Karla Salvagni , Ruver Cesar Alberto , Mohseni Ana Paula Vianna , Lopes Luizmar da Silva 
Published: October 2022

Abstract
The dynamic replacement (DR) method is a widespread alternative in several countries around the world as a technique to improve soils with low bearing capacity, compressible, collapsible, etc. It is an established method used on soft clays, silts, sandy silt, and/or sedimentary sandy soils with low bearing capacity. However, there are no published scientific reports on the use of this method on saprolite and/or laterite soils typical of tropical regions. Therefore, this paper aims to validate the use of the Mohr-Coulomb failure criterion using the finite element method (FEM) as a tool for predicting the elastoplastic behavior of lateritic clayey soils improved by the dynamic replacement method. For this purpose, 6 plate loading tests were performed on DR columns with and without cement-improved soil reinforcement layers (fine sand + Portland cement) with different heights and different DR column depths were numerically simulated in FEM based on the Mohr-Coulomb criterion. It was concluded that the use of the Mohr-Coulomb plastification criterion in FEM generated numerical simulations compatible with the responses of plate load tests performed in the field. In general, it was observed that the numerical model was able to represent the load vs. settlement behavior for different scenarios of varying granular column depth and reinforcement layer height.
Development of breeder chip for gene detection and molecular-assisted selection by target sequencing in wheat
Authors: Xiang Mingjie , Liu Shengjie , Wang Xiaoting , Zhang Mingming , Yan Weiyi , Wu Jianhui , Wang Qilin , Li Chunlian , Zheng Weijun , He Yilin , Ge Yunxia , Wang Changfa , Kang Zhensheng , Han Dejun , zeng qingdong 
Published: October 2022

Abstract
Wheat is an important food crop, but adversity stresses are becoming more common, resulting in significant yield losses. Accelerating molecularly assisted resistance breeding is critical. Through statistical analysis of published loci in wheat over the last two decades, we selected 60 loci with main breeding objectives, high heritability, and reliable genotyping, such as stress resistance, yield, plant height, and resistance to spike germination. Then, using genotyping by target sequencing(GBTS) technology, we developed a liquid phase chip based on 101 functional or closely linked markers. The genotyping of 42 loci was confirmed in an extensive collection of Chinese wheat cultivars, indicating that the chip can be used in molecular-assisted selection (MAS) for target breeding goals. Besides, we can perform the preliminary parentage analysis with the genotype data. The most significant contribution of this paper is to evaluate the target traits of breeding materials without conducting field experiments. Breeders can quickly screen germplasm resources, parental breeding materials, and intermediate materials for the presence of excellent allelic variants using the genotyping data by this chip, which is high throughput, convenient, reliable, and cost-efficient.
PGK1 is involved in the HIF-1 signaling pathway as a hub gene for ferroptosis after traumatic brain injury
Authors: Wang Zhao , Tian Jinjie , Wang Lei , Yan Hongyan , Feng Sujuan , Zhang Yi 
Published: October 2022

Abstract
The pathogenesis of ferroptosis in traumatic brain injury (TBI) is unclear, in this study, we aimed to identify key molecules associated with ferroptosis in TBI using bioinformatics analysis to determine its underlying mechanisms. GSE128543 dataset was downloaded from the Gene Expression Omnibus (GEO) database, and TBI-associated modules were obtained by weighted gene co-expression network analysis (WGCNA). We identified 60 differentially expressed genes (DEGs) by intersecting the modules with ferroptosis and glycolysis/gluconeogenesis gene libraries. The hypoxia-inducible factor-1 (HIF-1) signaling pathway was identified to be critical for ferroptosis post TBI, and protein–protein interaction (PPI) network identified 20 hub genes, including phosphoglycemicee kinase 1 (PGK1), ribosomal protein (RP) family, pyruvate kinase M1/2 (PKM), hypoxia-inducible factor 1α subunit (HIF-1α), and MYC genes. In this study, we further explored the role of PGK1, a gene involved in HIF-1 signaling pathway. Moreover, we constructed a TBI mice model and examined PGK1 and HIF-1α expression levels, and the results revealed their expressions increased after cortical injury in mice and they co-localized in the same cells. Furthermore, we examined the expressions of PGK1 in the cerebrospinal fluid of 20 clinical patients with different degrees of brain injuries within 48 h of surgery. The results revealed that PGK1 expression level was negatively correlated with the severity of the brain injury. These findings suggest that PGK1 may become a potential hub gene for ferroptosis via the HIF-1 signaling pathway, second to neurological injury after TBI, thereby affecting patient prognosis.
Deficiencies in the medical care of SMA: evidence from a nationwide patient registry in Germany
Authors: Leibrock Berenike , Landfeldt Erik , Hussong Justine , Huelle Tabea , Mattheus Hannah , Thiele Simone , Walter Maggie C , Zemlin Michael , Moehler Eva , Dillman Ullrich , Abner Sophia , Bastardas Marina Flotats 
Published: October 2022

Abstract
Background
Management and treatment of spinal muscular atrophy (SMA) has changed in recent years due to the introduction of novel transformative and potentially curative therapies resulting in the emergence of new disease phenotypes. Yet, little is known about the uptake and impact of these therapies in real-world clinical practice. The objective of this study was to describe current motor function, need of assistive devices, and therapeutic and supportive interventions provided by the healthcare system, as well as the socioeconomic situation of children and adults with different SMA phenotypes in Germany. We conducted a cross-sectional, observational study of German patients with genetically confirmed SMA identified and recruited via a nationwide SMA patient registry (www.sma-register.de) within the TREAT-NMD network. Study data was recorded directly from patient-caregiver pairs through a study questionnaire administered online via a dedicated study website.
Results
The final study cohort consisted of 107 patients with SMA. Of these, 24 were children and 83 adults. In total, about 78% of all participants were taking medication for SMA (predominantly nusinersen and risdiplam). All children with SMA1 were able to sit and 27% of children with SMA2 were able to stand or walk. Impaired upper limb function, scoliosis and bulbar dysfunction were observed more frequently in patients with reduced lower limb performance. Physiotherapy, occupational therapy, and speech therapy, as well as the use of cough assists were less common than indicated by care guidelines. Family planning and educational and employment status appear to be related to motor skill impairment.
Conclusions
We show that the natural history of disease has changed in Germany following improvements in SMA care and the introduction of novel therapies. Yet, a significant proportion of patients remain untreated. We also identified considerable limitations in rehabilitation and respiratory care, as well as low labour-market participation among adults with SMA, calling for action to improve the current situation.
Sexual violence is associated with poor treatment outcomes among transgender women living with HIV in Brazil
Authors: Leddy Anna M. , Veras Maria Amelia de Sousa Mascena , Saggese Gustavo Santa Roza , Bassichetto Katia Cristina , Gilmore Hailey J , Carvalho Paula Galdino Cardin , Maschião Luca Fasciolo , Neilands Torsten B. , Sevelius Jae , Lippman Sheri A. 
Published: October 2022

Abstract
Background: Transgender (trans) women are disproportionately affected by both HIV and gender-based violence (GBV), defined as physical, sexual, or emotional violence perpetrated against an individual based on their gender identity/expression. While a growing body of evidence demonstrates that GBV leads to poor HIV care and treatment outcomes among cisgender women, less research has examined this association among trans women. We assessed the impact of lifetime experiences of GBV on subsequent retention in HIV care and laboratory confirmed viral suppression among a sample of trans women living with HIV (TWH) in Brazil.
Methods: A pilot trial of a peer navigation intervention to improve HIV care and treatment among TWH was conducted in São Paulo, Brazil between 2018 and 2019. TWH were recruited and randomized into the intervention or control arm and participated in a baseline and 9-month follow-up survey and ongoing extraction of clinical visit, prescribing, and laboratory data. Generalized linear model regressions with a Poisson distribution estimated the relative risk (RR) for the association of lifetime physical and sexual violence reported at baseline with treatment outcomes at follow-up, adjusting for baseline sociodemographic characteristics.
Results: A total of 113 TWH participated in the study. At baseline, the median age was 30 years, and the prevalence of lifetime physical and sexual violence was 62% and 45%, respectively. At follow-up, 58% were retained in care and 35% had evidence of viral suppression. In adjusted models, lifetime physical violence was non-significantly associated with a 12% reduction in retention in care (RR: 0.88, 95% CI: 0.65, 1.19) and a 34% reduction in viral suppression (RR: 0.66; 95% CI: 0.40, 1.09). Lifetime sexual violence was significantly associated with a 28% reduction in retention in HIV care (RR: 0.72, 95% CI: 0.52, 0.99) and a 57% reduction in viral suppression (RR: 0.43; 95% CI: 0.23, 0.79).
Conclusion: Our findings are among the first to demonstrate that lifetime experiences of sexual violence are associated with subsequent reduced likelihood of retention in HIV care and viral suppression among trans women. Interventions seeking to improve HIV treatment outcomes should assess and address experiences of GBV among this population.
Trial registration: ClinicalTrials.gov Identifier: NCT03525340
The Feasibility of a Pea Protein Supplement with High Iron Bioavailability for Female Runners: A Randomized Control Trial
Authors: Shaw Keely A , Zello Gordon A , Lindsay Donna L , Warkentin Thomas D , Ko Jongbum , Chilibeck Philip D 
Published: October 2022

Abstract
Background: Iron deficiency is a global dilemma, with a high prevalence among females from both low- and high-income countries. Athletic females, especially those who engage in running, are at a particularly high risk of developing iron deficiency due to blood losses through menstruation coupled with decreased iron absorption secondary to exercise. Field peas, along with other plant-based protein sources, are rich in iron and inexpensive, making them an attractive option for those wishing to increase their iron intake without consuming more animal products. However, field peas are high in phytic acid, an inherent compound that binds to cations such as iron, forming a salt (phytate), and limiting absorption in the small intestine. The goal of the current research was to conduct a feasibility study to assess the acceptability of a high protein powder made from low phytic acid field peas in female runners.
Methods: Eight recreational female runners (age: 32.7 ±13.5 years; VO2max: 46.9±5.4 mL/kg/min) were assessed for iron status, body composition, and exercise performance before and after an 8-week intervention period, during which they supplemented with either a power derived from regular peas, a powder derived from peas with high iron bioavailability (low phytic acid), or maltodextrin.
Results: A high degree of compliance was observed, suggesting that supplementing with a high-protein pea powder derived from low phytic acid peas is feasible.
Conclusion: Techniques and protocol were acceptable and the values obtained were representative; therefore, a larger trial is warranted to investigate the role these peas might have in combating iron deficiency in athletes.
Trial Registration: NCT04872140
African Coastal Camera Network: Monitoring Ocean, Climate, and Human Impacts
Authors: Abessolo G. O. , Almar R. , Angnuureng D. B. , Bonou F. , Sohou Z. , Camara I. , Diouf A. , Alory G. , Onguéné R. , Mama A. C. , Cissé C. O. T. , Sy B. A. , Sakho I. , Djakouré S. , Yao S. , Tano A. R. , Bergsma E. W.J. , Dada O. A. 
Published: October 2022

Abstract

Regular and long-term monitoring of coastal areas is a prerequisite to avoiding or mitigating the impacts of climate and human driven hazards. In Africa, where populations and infrastructures are particularly exposed to risk, there is an urgent need to establish such a monitoring as observations are generally scarce. Measurement campaigns and very high-resolution satellite imagery are costly, while freely satellite observations have temporal and spatial resolutions that are not suited to capture the event scale. To address the gap, a network of low-cost multi-variable shore-based video camera stations is been installed along the African coasts. Here, we present this network and its principle of sharing data, methods, and results obtained, building toward the implementation of common integrated coastal management policy between countries. Further we list new contributions in the understanding of still poorly documented African beaches evolution, waves, and sea level impacts. This network is a solid platform for the development of inter-disciplinary observations for resource and ecology (such as fisheries, and sargassum landing), erosion and flooding, early warning system during extreme event, and science-based coastal infrastructure management for sustainable future coasts.
Hearing Screening Test in neonates born to COVID-19-positive mothers
Authors: Goulioumis Anastasios , Angelopoulou Maria , Kourelis Konstantinos , Mourtzouchos Konstantinos , Tsiakou Magdalini , Asimakopoulos Athanasios 
Published: October 2022

Abstract
Purpose
SARS-CoV-2, the responsible virus for the covid-19 pandemic, has demonstrated neurotropic properties indicated by cases presenting with auditory and vestibular system insults. The expression of ACE-2 receptors in the placenta and the detection of IgM antibodies against the virus in the fetuses of pregnant women suffering from covid-19 render vertical transmission of the infection to the fetus possible. Thus, our study aims to examine whether, similar to other viruses like CMV, SARS-CoV-2 is responsible for congenital hearing loss.
Methods
This is a retrospective study in a regional pediatric hospital. The medical records of newborns (n = 111) born by mothers positive for COVID-19 during pregnancy who underwent screening hearing tests with Transient Evoked Otoacoustic Emissions (TEOAE) and Automatic Auditory Brainstem Response (AABR) from February 2020 to June 2022 were reviewed. Neonates with additional aggravating factors for congenital hearing loss were excluded from the study.
Results
For the study period, nine mothers were found positive during the first trimester, twenty mothers in the second trimester, and eighty-three mothers in the third trimester. TEOAEs test and AABR test scored PASS bilaterally in all neonates tested.
Conclusions
Infection with COVID-19 during pregnancy was not a risk factor for hearing loss, similar to other studies.
Serum metabolome signatures characterizing co-infection of Plasmodium falciparum and HBV in pregnant women
Authors: Asantewaa Gloria , Anabire Nsoh Godwin , Bauer Michael , Weis Sebastien , Neugebauer Sophie , Quaye Osbourne , Helegbe Gideon Kofi 
Published: October 2022

Abstract
Background
Plasmodium falciparum (P. falciparum) and hepatitis B virus (HBV) co-infection is prevalent among pregnant women in northern Ghana and found to induce an augmented inflammatory immune response and aggravate liver damage. Both pathogens occupy a common intrahepatic niche and their activities can be characterized by specific serum metabolites in infected individuals. Thus, clarifying the metabolome signatures associated with P. falciparum and chronic viral hepatitis B co-infection could give an indication to the metabolic pathways that are impacted and provide useful prognostic or diagnostic markers.
Methods
Using MS/MS-based targeted metabolomic approach, we determined the serum metabolome in a well characterized cohort of pregnant women with either P. falciparum mono-infection, HBV mono-infection, P. falciparum and HBV co-infection or in un-infected (control) women.
Results
We observed that concentrations of sphingolipids were significantly decreased in subjects with P. falciparum mono-infection. Whereas amino acids and phospholipids were decreased in subjects with HBV mono-infection. Co-infection of the two pathogens was found to be characterized predominantly by reduced concentrations of phospholipids and hexoses (mostly glucose). Additionally, co-infection was characterized by altered pathways that contribute to redox homeostasis. Through ROC analysis, PC ae C40:1 was found to be discriminating for the co-infection group.
Conclusions
Put together, the metabolite PC ae C40:1, could serve as a potential biomarker for characterizing the co-infection, and can further be explored for use in diagnosis and treatment of malaria and chronic hepatitis B co-morbidity as well as distinguishing co-infections from cases of mono-infections.
AI-Controlled Closed-Loop Electrical Stimulation Implants: A Feasibility Study
Authors: Eickhoff Steffen , Garcia-Agundez Augusto , Haidar Daniela , Zaidat Bashar , Adjei-Mosi Michael , Li Peter , Eickhoff Carsten 
Published: October 2022

Abstract
Miniaturized electrical stimulation (ES) implants show great promise in practice, but their real-time control by means of biophysical mechanistic algorithms is not feasible due to computational complexity. Here, we hypothesize machine learning methods can approximate these models while being much more computationally efficient. To prove this hypothesis, we estimate the normalized twitch force of the stimulated extensor digitorum longus muscle on n=11 Wistar rats with intra- and cross-subject calibration. After 2000 training stimulations, we reach a mean absolute error of 3% in an intra-subject setting and 20% in a cross-subject setting with a random forest regressor. To the best of our knowledge, this work is the first experiment showing the feasibility of AI to simulate complex ES mechanistic models. However, the results of cross-subject training motivate more research on error reduction methods for this setting.
Voluntary running-induced activation of ventral hippocampal GABAergic interneurons contributes to exercise-induced hypoalgesia in neuropathic pain model mice
Authors: Minami Kohei , Kami Katsuya , Nishimura Yukihide , Kawanishi Makoto , Imashiro Kyosuke , Kami Takuma , Habata Shogo , Senba Emiko , Umemoto Yasunori , Tajima Fumihiro 
Published: October 2022

Abstract
The exact mechanism of exercise-induced hypoalgesia (EIH) in exercise therapy to improve chronic pain has not been fully clarified. Recent studies have suggested the importance of the ventral hippocampus (vHPC) in inducing chronic pain. We investigated the effects of voluntary running (VR) on glutamate (Glu) neurons and GABAergic interneurons (parvalbumin-positive [PV+] and somatostatin-positive [SOM+]) in the vHPC-CA1 region in neuropathic pain (NPP) model mice. VR significantly improved thermal hyperalgesia in the NPP model. The number of activated (FosB+) glutamate (Glu) neurons was significantly higher in partial sciatic nerve ligation-sedentary mice than in Sham and Naive mice, whereas VR significantly suppressed the activation of Glu neurons in the vHPC-CA1 region. Furthermore, VR significantly increased the proportion of activated PV+ and SOM+ interneurons in the vHPC-CA1 region, and tracer experiments indicated that approximately 24% of neurons projecting from the vHPC-CA1 region to the basolateral nucleus of amygdala were activated in NPP mice. These results indicate that feedforward suppression of Glu neurons via VR-induced activation of GABAergic interneurons in the vHPC-CA1 region may be a mechanism to produce EIH effects, and suggested that disappearance of negative emotions such as fear and anxiety by VR may play a critical role in improving chronic pain.