bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulasi orally disintegrating tablet dari serbuk kembang kol (Brassica oleracea var. botrytis L.) dengan variasi konsentrasi sari tapai sebagai disintegrant
Authors: Lestari Sri Indah , Dalimunthe Gabena Indrayani , Lubis Minda Sari , Nasution Haris Munandar 
Published: February 2025

Kembang kol (Brassica oleracea var. botrytis L.) memiliki kandungan zat gizi yang terdiri dari kalsium, magnesium, kalium, fosfor, lemak jenuh yang rendah. dan memiliki vitamin C yang membantu meningkatkan imunitas tubuh. Sediaan Orally Disintegrating Tablet dapat cepat larut jika diletakkan diatas lidah, diformulasikan untuk kemudahan penggunaan obat bagi pasien yang kesulitan menelan. Oleh karena itu, bahan penghancur sangat penting pada sediaan ODT. Sari tapai memiliki rasa manis, sedikit asam dan segera hancur bila diletakkan di lidah. Tujuan penelitian ini untuk mengetahui apakah serbuk kembang kol dengan penghancur sari tapai dapat diformulasikan menjadi sediaan ODT dan formulasi manakah yang terbaik. Penelitian ini meliputi karakterisasi simplisia, pembuatan preformulasi dengan pencampuran semua bahan, evaluasi preformulasi, pencetakan tablet dengan metode kempa langsung. Kemudian dilakukan evaluasi tablet. Bahan penghancur yang digunakan yaitu sari tapai dengan konsentrasi 5%,7,5% dan 10%. Data dianalisis dengan metode One Way ANOVA. Hasil evaluasi preformulasi, uji waktu alir yang diperoleh <10 detik yaitu mudah mengalir, uji sudut diam diperoleh 26˚ kategori sangat baik, dan uji kompresibilitas diperoleh 18-20% kategori cukup baik. Hasil evaluasi tablet pada uji organoleptis diperoleh tablet berbentuk bulat, rasa manis, warna putih kecoklatan dan bau khas. Uji keseragaman bobot pada semua formula tidak ada bobot yang menyimpang, uji keseragaman ukuran telah memenuhi syarat, uji kekerasan yang diperoleh 1-3 kg, uji kerapuhan diperoleh 0,4-0,7%, uji waktu hancur cawan petri diperoleh 44,07-52,48 detik, uji waktu hancur mulut diperoleh 53,07-57,78 detik dan uji waktu pembasahan diperoleh 53,21-54,87 detik. Formula terbaik adalah formula dengan konsentrasi sari tapai 10%.
IMPACTO DO GLAUCOMA NA SAÚDE PÚBLICA: ANÁLISE EPIDEMIOLÓGICA (2014-2024)
Authors: Cardoso dos Santos Iasmin Carmo , Bedin Sarolli Maria Eduarda , Araujo Cardoso Joice , Dantas da Silva Gabriel Pinto , Barros Silva Yasmin , Lebram Martinelli Braga Maria Fernanda , Mota Miranda Sara da , Trindade Santos Pina Natalia , Da Silva Avelar Luanda , Macedo Silva Vinicius , Pinheiro Parnaíba Mirlandia , Araújo e Souza Sophia , Mascarenhas da Silva Priscilla , Mesquita Alves Costa João Pedro , Feitosa Syone de Jesus 
Published: February 2025

Introdução: O glaucoma é uma das principais causas mundiais de perda irreversível da visão. É uma doença que causa neuropatia óptica progressiva e irreversível associadas a defeitos característicos do campo visual e alterações estruturais. Esta doença cursa com diminuição da acuidade visual e consequente declínio na qualidade de vida dos pacientes. Com isso, a identificação de fatores de risco e da doença em seu estágio inicial e o encaminhamento ágil e adequado para o atendimento especializado é essencial para um melhor resultado terapêutico e prognóstico dos casos. Objetivo: Este estudo tem como objetivo avaliar o perfil epidemiológico do glaucoma no Brasil, identificando a prevalência e a relevância do diagnóstico precoce, visando contribuir para estratégias de prevenção e manejo adequado da doença. Metodologia: Trata-se de um estudo epidemiológico, retrospectivo com abordagem quantitativa e retrospectiva, com dados referentes à prevalência e impactos das internações no período de 2014 a 2024, nas cinco regiões brasileiras. Resultados: Das 60.903 internações analisadas, a maior concentração ocorreu nas regiões Sudeste (47%), já quanto ao sexo, há predominância de internações entre homens (52%) em relação às mulheres (47%). Com isso, dentre o número de internações, prevalece os casos de pacientes na senilidade, principalmente entre 60 a 69 anos. Em relação à cor/raça, a maioria das internações foi entre pessoas pardas (20.146 casos), seguidas por brancas (18.926 casos). Por fim, o ano de 2023 foi o que registrou o maior número de internações (9.149), seguido por 2022 (7.743 casos). Conclusão: Para a prevenção do glaucoma é imprescindível que os pacientes conheçam a doença e disponham de atendimento adequado para o diagnóstico precoce, trazendo a população para perto do oftalmologista. Portanto, para reduzir o índice de cegueira por esta patologia, a literatura sugere uma estratégia a ser desenvolvida com o intuito de estimular o diagnóstico precoce da doença na comunidade, incluindo o reconhecimento da dimensão do problema, a facilitação do acesso ao atendimento primário e educando a população sobre o glaucoma, seus fatores de risco, tratamento e consequências. Destacando, então, a importância de expor esse tema com maior frequência, buscando instigar o meio acadêmico e científico a aprimorar os conhecimentos acerca dessa problemática e conseguir um resultado efetivo ajudando a população a prevenir e tratar o glaucoma.
EFICÁCIA DO OCLACITINIB E DO LOKIVETMAB NO CONTROLE DA DERMATITE ATÓPICA CANINA: UM ESTUDO COMPARATIVO
Authors: Barreiro Luiza Fernandes Guimarães , Santos Maryane Gomes Marreiros dos , Silva Caroline Pena , Ramos Jéssica Vieira , Seilert Nadia dos Anjos , Cidral Letícia Orthey , Cauás Danila Duca , Gomes Letycia Vilela , De Souza Maileide Guimarães , Ferreira Ana Rogéria Andrade Oliveira , Costa Luana Henriques 
Published: February 2025

A dermatite atópica canina (DAC) é uma condição crônica frequente que prejudica a pele canina, sendo afetada por elementos genéticos, ambientais e imunológicos. O objetivo deste estudo é comparar a eficácia do oclacitinib e do lokivetmab no controle da DAC, avaliando seu impacto no bem-estar dos cães e na qualidade de vida dos tutores. A metodologia adotada envolveu uma revisão narrativa da literatura, utilizando artigos em bases de dados como PubMed, ScienceDirect, Scielo e Google Scholar, utilizando termos ligados à dermatite atópica, oclacitinib, lokivetmab e qualidade de vida canina. Os resultados indicam que o oclacitinib proporciona um alívio imediato dos sintomas, com uma melhora notável em menos de 48 horas, ao passo que o lokivetmab oferece um alívio duradouro, com uso mensal. O estudo conclui que ambos os tratamentos possuem eficácia comprovada, porém apresentam variações na frequência de administração e no custo. O uso adequado de cada uma das medicações pode aprimorar o tratamento da enfermidade em questão e a qualidade de vida dos cães.
Eficiencia y Rentabilidad de los Abonos Orgánicos de Origen Animal de Estiércol Vacuno y Guano de Murciélago en la Producción de Hortalizas
Authors: Valdes Vega José Luis , Trigueros Salmerón José Ángel 
Published: February 2025

Se determinó la eficiencia y rentabilidad de abonos orgánicos en cultivos experimentales de cilantro, cebolla, lechuga, zanahoria, rábano y tomate, en Los Mochis Sinaloa. Empleando un modelo experimental de tres tratamientos con dos repeticiones; dos orgánicos (tratamiento vacuno-TV y tratamiento guano-TG) y un tratamiento inorgánico (tratamiento testigo-TT). Con el objetivo de evaluar la eficiencia de los abonos orgánicos en el crecimiento promedio de altura de planta, se seleccionaron 6 plantas y 20 muestras para determinar el peso, diámetro polar, ecuatorial del fruto y biomasa para obtener ANOVA de una vía entre tratamientos. Los resultados mostraron que en cilantro y cebolla se observó un mayor crecimiento promedio de altura de planta con mismo comportamiento en % de materia seca en cilantro, cebolla, rábano y tomate con tratamientos orgánicos. Se encontraron diferencias significativas entre los tres tratamientos. En cuanto al análisis económico, en el escenario con valor del mercado en el norte Sinaloa (local), sólo el cilantro presenta razón beneficio/costo (B/C) mayor a 1, con los tres tratamientos. Y en el escenario del mercado de Sinaloa, el TV y TG tienen rentabilidad en los 6 cultivos ya que su relación B/C resulta superior a 1.
How CO Affects the Composition of Titan’s Tholins Generated with Electron Cyclotron Resonance Plasma
Authors: Yang Zhengbo , Liu Yu , He Chao , Yu Pengcheng , Jin Rong , Liu Xiangqun , Zhang Jinpu , Lei Jiuhou 
Published: February 2025

Abstract
Titan’s atmosphere possesses thick haze layers, but their formation mechanisms remain poorly understood, including the influence of oxygen-containing gas components on organic matter synthesis. As the most abundant oxygen-containing gas, the presence of

CO

has been found to exert a significant impact on the generation of oxygen-containing organic compounds. Therefore, investigating the influence of

CO

on the production and composition of tholins through laboratory simulations holds profound scientific significance in the context of Titan. The work presented here is an experimental simulation designed to evaluate the impact of

CO

on the atmospheric chemistry of Titan. To this end,

CO

was introduced into the standard

N

2

/
C

H

4

mixture at varying mixing ratios from 0.2% to 9% and exposed to electron cyclotron resonance plasma to initiate photochemical reactions. Optical emission spectroscopy was employed for gas-phase in situ characterization, while infrared spectroscopy and high-resolution mass spectrometry were used to analyze the resulting solid products (tholins). Our results demonstrate that the addition of

CO

enriches the complexity of the chemical system.

CO

not only supplies oxygen to the system but also enhances nitrogen’s reactivity and incorporation, enhancing the number and quantity of the organic products.
Laboratory Study of Dust Mobilization on Airless Planetary Bodies in the Solar Wind Plasma
Authors: Cabra A. , Wang X. , Horányi M. 
Published: February 2025

Abstract
Dust charging, and the subsequent mobilization and transport, have been suggested to explain a number of unresolved and unusual features observed on airless planetary surfaces. These processes are also critical for understanding and mitigating potential dust hazards to human and robotic exploration on the lunar surface. A patched charge model (PCM), developed from recent laboratory and theoretical studies, shows that secondary electrons and/or photoelectrons absorbed inside microcavities between dust particles on the surface of airless bodies can accumulate unexpectedly large negative charges, causing dust mobilization and lofting due to strong repulsive forces. Complementary to previous work with secondary electrons induced by an electron beam and/or photoelectrons induced by ultraviolet (UV) radiation, here we present dust mobilization due to ion-induced secondary electrons in a simulated solar wind plasma with the energies of nitrogen ions in the range of 100–1000 eV. It is shown that dust mobility is correlated with the secondary electron emission that is determined by the energy- and material-dependent emission yield, as well as the electrostatic potential profile developed above the surface. Our results provide a new charging mechanism by the solar wind plasma based on the PCM, which is expected to play an important role in dust mobilization in permanently shadowed regions, where the solar wind ions can be diverted onto areas that are not accessible to UV radiation.
First report of an intersex individual of the click beetle Pectocera fortunei (Elateridae) and additional cases of gynandromorphism in Coleoptera (Lucanidae, Scarabaeidae)
Authors: Kim Donguk , Hyun Sangeun , Choi Kwang Shik 
Published: February 2025

The occurrence of individuals exhibiting both male and female phenotypes is a rare phenomenon observed across various insect orders.
This study documents the first case of an intersex individual of Pectocera fortunei Candèze, 1873, from the Korean Peninsula, including behavioural findings. This is the first report of such a phenomenon in the family Elateridae. Two cases of gynandromorphism are also described: one in Dorcus titanus castanicolor (Motschulsky, 1861) (Lucanidae) and the other in Trypoxylus dichotomus septentrionalis (Kôno, 1931) (Scarabaeidae). The former is a new record for this subspecies. An updated list of intersex and gynandromorphic beetles is also provided.
Factors that determine female entrepreneurial intention: A systematic review of the literature
Authors: Gallegos Ada , Rodríguez Zavala Luisa , Martínez Valera Pedro , Bouroncle Velásquez Mauricio Renato , Vega-Mori Luis , Teodori de la Puente Renata , Valencia-Arias Alejandro 
Published: February 2025

Purpose: The interest of women in entrepreneurship is considered a catalyst for economic growth in developing countries. However, female representation among entrepreneurs remains comparatively low in relation to their male counterparts, a phenomenon that has garnered the attention of numerous researchers. The present study aims to analyze the entrepreneurial intentions of university students through a systematic review of the extant literature. It seeks to identify the most salient thematic trends, understand the factors that determine these intentions, and highlight the challenges and opportunities in this field. The study's overarching objective is to furnish a framework to guide future research by exploring existing gaps and potential connections between key theories and variables within the context of female university entrepreneurship.Design/methodology/approach: A systematic review of the literature based on PRISMA 2020 is proposed, which synthesizes quantitative and qualitative literature on the subject.Findings: Research on entrepreneurial intention among university women has grown exponentially, focusing on "self-efficacy.” Concepts such as "Covid-19" and "entrepreneurial passion" are highlighted. The prevailing theories include the Theory of Planned Behavior (TPB), which provides a solid framework. Attitude, subjective norms, self-efficacy, entrepreneurial education, and behavioral control were key variables. Gaps include preferences for TPB and a lack of understanding of emerging economies and gender. A comprehensive agenda is needed to address these gaps and to advance the understanding of entrepreneurial intentions among university women.Originality/value: This study's originality lies in its comprehensive systematic review of the literature on entrepreneurial intentions among university women. It stands out for its detailed analysis of dominant theories, key variables, and identified research gaps in this field. Moreover, the study's cross-cutting focus on the concept of 'self-efficacy' and the inclusion of emerging themes such as entrepreneurial passion and social support, along with the potential impact of the Covid-19 pandemic, add a current and relevant dimension to understanding women's entrepreneurial motivations in the university context.
As mulheres na economia da existência e os programas institucionais de apoio a elas
Authors: Lisboa Pacheco Maria Emília , Prévost Héloïse 
Published: February 2025

Na 7ª Marcha das Margaridas, em 2023, foi palestrante no painel temático dedicado à Soberania alimentar e agroecologia como o caminho para a superação da fome (15.08.2023). Ela gentilmente concordou em nos permitir transcrever aqui o texto de sua palestra, na qual ela discute os desafios, nesse contexto político, de reconstruir o acesso aos direitos e à soberania alimentar, entre outras coisas. Enquanto algumas feministas na França valorizam as questões ecofeministas de « subsistência », a palestra de Maria Emília Lisboa Pacheco demonstra uma politização diferente elaborada nas questões de economia da existência e de economia do cuidado. Algumas informações foram atualizadas de 2023 para 2024 com a nova situação governamental.
Les femmes rurales construisent l’économie de l’existence. Quels programmes institutionnels pour les soutenir ?
Authors: Lisboa Pacheco Maria Emília , Prévost Héloïse 
Published: February 2025

Lors de la 7e Marche des Margaridas en 2023, elle a été intervenante à la conférence thématique consacrée à la « Souveraineté alimentaire et l’agroécologie comme voie pour vaincre la faim » (15.08.2023). Elle a aimablement accepté que nous transcrivions ici le texte de son intervention, dans laquelle elle évoque les enjeux, dans ce contexte politique, de la reconstruction de l’accès aux droits et aux programmes publics pour la souveraineté alimentaire, entre autres. Alors que des féministes en France valorisent l’approche écoféministe de la « subsistance », l’intervention de Maria Emília Lisboa Pacheco témoigne d’une politisation différente élaborée à partir des perspectives d’économie de l’existence et d’économie du care. Certaines informations ont été mises à jour de 2023 à 2024 en lien avec la nouvelle situation gouvernementale.
Les femmes dans les systèmes agroalimentaires, action collective et politiques publiques (2019 à 2022)
Authors: Butto Andrea , Eden Marielle 
Published: February 2025

Les inégalités de genre, les inégalités intersectionnelles et les positionnalités sont entretenues par la division sexuelle du travail productif et reproductif, générant une surcharge de travail et des restrictions à l’accès aux biens et aux politiques publiques. L’action collective des mouvements sociaux des femmes rurales a mis en lumière la contribution des femmes au développement rural au Brésil et dans le monde ces dernières années. En jouant un rôle de premier plan dans la lutte contre les entreprises transnationales, en élaborant des alternatives populaires et en proposant des politiques publiques, les femmes rurales ont acquis une plus grande reconnaissance. Depuis les années 2000, des politiques publiques ont été construites durant les gouvernements populaires afin de rendre effectifs les droits des femmes rurales. La réaction conservatrice ayant porté au coup d’État parlementaire de 2016 a provoqué l’extinction ou le démantèlement de politiques publiques. Ce n’est que récemment que l’on a assisté à une reprise des acquis. L’objectif de cet article est de réfléchir sur ces processus de changement, sur les stratégies sociales et politiques développées afin de mettre en évidence les nouveaux programmes portés par les mouvements sociaux et les réponses de l’État. Nous prenons comme exemple le cas du Programme d’Organisation Productive et une étude de cas réalisée dans l’Agreste Méridional, une micro-région de l’État du Pernambouc, dans la région Nordeste du Brésil.
L’Université pendant le Covid et l’alternative au présentiel : quelle continuité pédagogique ?
Authors: Senouci Zoubida 
Published: February 2025

Comme dans de nombreux pays, l’enseignement à distance, en Algérie a été présenté comme alternative au présentiel suite au confinement imposé par la pandémie Covid 19 et à la fermeture des universités en mars 2020. En nous appuyant sur les données issues d’entretiens menés avec des enseignants et des étudiants d’une école d’ingénieurs, nous nous intéressons à la question de la continuité pédagogique. Quelles ont été leurs pratiques d’enseignement/apprentissage pendant le confinement ? L’enseignement à distance a-t-il représenté une alternative au présentiel pour assurer la continuité pédagogique ? Comment a-t-elle été assurée ? Quelles en ont été les difficultés ? Y a-t-il eu émergence de changement dans la forme scolaire traditionnelle ?
Scolarisés face à la déscolarisation imposée : un quotidien inédit
Authors: Benghabrit Remaoun Nouria 
Published: February 2025

La Covid-19, au travers des mesures sanitaires draconiennes prises, a créé un sentiment fort d’instabilité dans la communauté éducative, pour la famille, avec pour conséquence, une relative perte de repère pour les élèves.L’enquête nationale menée en mars 2021 au Crasc, a permis, en temps réel, de suivre les angoisses et les espoirs d’une société frappée d’une crise inégale. Les mesures radicales de fermeture des écoles, puis d’une réorganisation spatio-temporelle, vont accentuer les difficultés, non seulement pour ceux déjà en situation « d’échec », mais aussi d’identifier les populations à risque de déscolarisation précoce.
Adipose-derived stem cells exosomal circHIPK3 protects ovarian function by regulating MAPK signaling
Authors: Zhao Wei , Erhan Da , Liu Shujun , Zhang Liyan , Hai Caizhu , Zhang Yanan , Li Haiyan , Wang Hongwu , Wang Caisheng 
Published: February 2025

Abstract:

BACKGROUND:
Exosomes derived from adipose-derived stem cells (ADSCs) have garnered significant attention for their therapeutic potential in various diseases. These vesicles are capable of transporting bioactive molecules such as noncoding RNAs and proteins. Among these noncoding RNAs, circular RNAs (circRNAs) are characterized as end-to-end circular structures, which are notably enriched within exosomes.

OBJECTIVE:
This study aims to investigate the impact of the circHIPK3 delivered via ADSC-derived exosomes on ovarian aging.

MATERIALS AND METHODS:
ADSCs were isolated, and exosomes were obtained from a cell culture medium. The exosomes were labeled with PKH26, and uptake by primary granulosa cells (pGCs) was detected. ADSCs were transfected with circHIPK3 siRNAs, and the exosomes were isolated for the treatment of aging female mice. Ovary weight was recorded, and HE staining, Masson’s trichrome, and TUNEL staining were performed to detect tissue morphology and apoptosis in ovary tissues. In addition, the senescence and apoptosis of pGCs were evaluated using the S-β-gal staining kit and Annexin V/PI detection kit. Further experiments included immunoprecipitation and RNA pulldown, determined the ubiquitination of p38 protein under circHIPK3 alteration.

RESULTS:
Results showed that ADSC-derived exosomes effectively delivered circHIPK3 to pGCs. Treatment with these exosomes significantly increased ovary weight and enhanced follicular development in aged mice. Conversely, the depletion of circHIPK3 reversed these effects, promoting cell apoptosis. ADSC-derived exosomes also mitigated senescence and apoptosis in pGCs, while circHIPK3 depletion hindered these benefits.

CONCLUSION:
Exosomal circHIPK3 modulated the ubiquitination of p38 in pGCs to improve ovarian function in aging mice and to promote pGC cell viability.
Aspirin for prophylaxis of VTE in patients with Hip/ Knee replacement: Systematic review and Meta-analysis of Non-Randomized studies
Authors: Maddukuri Raghava Kalyan , Chava Hema , Kondaveeti Sri Tejaswi , Mutthineni Mounika Venkata , Vegesana Bindu Priyanka 
Published: February 2025

Abstract:
Aspirin as an agent for thromboprophylaxis in patients with total knee replacement (TKR) and total hip replacement (THR) is gaining a lot of importance owing to its efficacy and safety in preventing venous thromboembolism (VTE) complications. The current guidelines do not recommend aspirin over other anticoagulants as the data from the meta-analysis of randomized controlled trails (RCTs) lacked a significant sample to draw conclusive results. The present study was aimed to carry out a systematic review and meta-analysis of nonrandomized studies (NRSs) to determine the effect of aspirin as prophylaxis for VTE. A complete electronic search was conducted at PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar for relevant articles published till March 2021. Any postsurgical VTE event (deep vein thrombosis and/or pulmonary embolism) is considered the primary outcome and adverse events as secondary outcomes. Both efficacy and safety outcomes were reported as pooled risk estimates with 95% confidence interval (CI) with a level of significance at P < 0.05. A total of 21 studies were identified for the analysis. The overall risk of occurrence of VTE among the patients taking aspirin was not significantly different from anticoagulants (risk ratio [RR]: 0.78, 95% CI: 0.52–1.15). Patients who underwent THR had a higher risk for VTE with aspirin (RR: 1.50, 95% CI: 1.35–1.61), whereas the patients who underwent TKR showed a lower risk of VTE with aspirin (RR: 0.80, 95% CI: 0.75–0.85). Meta-analysis of NRS advocates the role of aspirin as a prophylactic agent for VTE, especially for patients who are in need for TKR. Further RCTs are required to reestablish the role of aspirin, especially in patients undergoing THR.