bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningkatkan Motivasi dan Kemampuan Siswa Kelas Xi Ips Sma Negeri 1 Cigugur dalam Menyusun Proposal Melalui Pendekatan Pembelajaran Kotekstual
Authors: Komalasari Sri 
Published: December 2022

Sri Komalasari, Spd. telah melaksanakan Penelitian Tindakan Kelas (PTK) yang berjudul : Meningkatkan Motivasi Dan Kemampuan Siswa Kelas XI IPS SMA Negeri 1 Cigugur dalam Menyusun Proposal Melalui Pendekatan Pembelajaran Kontekstual. Penelitian berawal dari pengamatan peneliti sebagai guru mata pelajaran Bahasa Indonesia di SMA Negeri 1 Cigugur Kabupaten Kuningan terdapat 26 siswa kelas XI IPS-2 pada akhir semester-1 tahun pelajaran 2020/2021, yang menyimpulkan bahwa kemampuan siswa di kelas tersebut dalam mata pelajaran Bahasa Indonesia tidak mencapai ketuntasan kelas minimal ideal, hal ini diduga karena motivasi siswa selama proses pembelajaran kurang kuat yang berdampak terhadap rendahnya kemampuan mereka setelah proses pembelajaran. Melihat hal itu penulis mencari jalan keluar agar motivasi siswa selama proses pembelajaran sangat kuat sehingga kemampuan mereka setelah proses pembelajaran mencapai kriteria ketuntasan klasikal minimal ideal yang ditetapkan sebesar 85 % berdasarkan konsep belajar tuntas (Mastery Learning). Untuk itu penulis melakukan Penelitian Tindakan Kelas (PTK) tentang penggunaan pendekatan pembelajaran Kontekstual pada pembelajaran Bahasa Indonesia di kelas tersebut, dengan permasalahan penelitian : Apakah dengan penggunaan pendekatan pembelajaran Kontekstual dapat meningkatkan motivasi dan kemampuan siswa dalam Menyusun Sebuah Proposal. Melalui penelitian dalam 2 siklus, yang masing-masing siklus terdiri dari tahapan perencanaan, pelaksanaan, pengamatan, dan refleksi yang berlangsung dalam bulan Januari dan Februari 2021, dengan subjek tindakan penelitian adalah 26 siswa kelas XI IPS-2, SMA Negeri 1 Cigugur, menyimpulkan bahwa penggunaan pendekatan pembelajaran Kontekstual dapat meningkatkan motivasi dan kemampuan siswa dalam Menyusun Proposal dengan signifikan, yakni motivasi siswa mengalami peningkatan dari cukup kuat menjadi sangat kuat, kemampuan siswa meningkat dari belum tuntas menjadi tuntas dan uji signifikansi peningkatan motivasi dan kemampuan siswa pada taraf 1 % menunjukan t hitung < t tabel. Dari hasil penelitian ini dapat disarankan agar para guru, baik guru mata pelajaran Bahasa Indonesia maupun guru mata pelajaran lain supaya segera mulai mencoba menggunakan pendekatan pembelajaran Kontekstual sebagai upaya untuk meningkatkan motivasi dan kemampuan siswa
Analisis Kandungan Bahan Kimia Obat Natrium Diklofenak Dalam Jamu Encok
Authors: Haikal Rivani Vikri , Selendra Novitalia , Alawiyah Tuti 
Published: December 2022

Jamu adalah salah satu produk warisan budaya di Indonesia yang sudah digunakan secara turun-temurun untuk pengobatan. Tujuannya untuk memberikan efek terapi yang lebih maksimal sehingga produk yang dihasilkan lebih laku di pasaran Pada analisis kadar obat Natriun Diklofenak terdapat 2 metode umum yang digunakan yakni secara kualitatif menggunakan Kromatografi Lapis Tipis dan secara kuantitatif menggunakan Spectrofotometri UV-vis. Hasil analisis kualitatif pada Sampel Jamu Pegel Linu/encok memiliki nilai Rf yakni 0,87 sedangkan pada larutan standar Natrium Diklofenak memiliki nilai Rf yakni 0,65. Hasil tersebut membuktikan adanya kandungan obat pada sampel sediaan jamu tersebut. Dapat disimpulkan dari hasil yang kami dapatkan saat praktikum,dengan pengujian menggunakan 2 metode yaitu secara Kualitatif dan Kuantitatif, bahwasanya produk yang kami uji yaitu jamu pegel linu mengandung Natrium Diklofenak, Sehingga jamu tidak layak untuk diedarkan.
Numerical Modeling of Surface-Piercing Flexible Hydrofoils in Waves
Authors: Wheeler Miles P. , Matveev Konstantin I. 
Published: December 2022

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Hydrofoils made of metal alloys were broadly used on high-speed boats in the past. Nowadays, much lighter hydrofoils made of composite materials are finding increasingly more applications on sailing yachts and powerboats. However, these hydrofoils are usually rather flexible, and their design requires computationally demanding analysis, involving hydroelastic calculations. In this study, exploratory high-fidelity simulations have been carried out for surface-piercing hydrofoils in unsteady conditions with help of a computational fluid dynamics solver for fluid flow coupled with a finite element solver for the foil structure. To model unsteady foil deformations, the morphing mesh approach was utilized, and the volume-of-fluid method was applied for multiphase flow simulations. The computational setup, as well as verification and validation study, is described in this paper. Three hydrofoils of different stiffness, including a perfectly rigid foil, were simulated in both calm water conditions and regular head waves. Representative examples of foil deflections and wave patterns, as well as time-dependent structural and hydrodynamic characteristics, are presented.

Introduction
Hydrofoils are efficient lift-generating devices intended for application in water flows. Hydrofoils have streamlined shapes, and when operating at small incidence angles, they can produce high lift forces at relatively low drag, when moving in a certain speed range. Due to this ability, hydrofoils and their derivatives are commonly used as control and propulsive devices, e.g., as rudders, fins, and propeller sections.
In the second half of the last century, hydrofoils found broad applications on fast boats, such as passenger ferries and military ships (McLeavy 1976; Matveev & Duncan 2005). These craft were able to achieve high speeds at lift–drag ratios (LDR) around 12–15, significantly higher than LDR of other hulls, such as planing boats. However, due to rather limited favorable operational conditions with regard to speed and payload, popularity of hydrofoils somewhat receded. One of drawbacks was that hydrofoils were usually made of metal alloys, thus being relatively heavy and difficult to service.
EL MICROLEARNING (MICROAPRENDIZAJE) COMO HERRAMIENTA DIDÁCTICA EN LA ASIGNATURA MICROBIOLOGÍA I DEL GRADO DE VETERINARIA
Authors: Ortega Hernández Nieves 
Published: December 2022

Microlearning has been used as a teaching tool in an innovation project carried out with students of the subject Microbiology I in the Veterinary Medicine Degree at the University of Murcia. The students, guided by their teacher, elaborated training pills (2-5 minutes long videos) of the practical sessions of the subject. The training pills, once reviewed and corrected, were published in a private account of a famous social network (Instagram). Subsequently, the training pills went through a selection process by the students and the teacher. The best formative pill of each practical session was published in the Multimedia Gallery tool of the subject at Virtual Classroom, generating a didactic resource developed entirely by the student and for the students of this subject. Participation of 95% of the students was achieved, 65% of them prepared one or more training pills. The innovation project received a very good response from the students, motivated them in their learning process and encouraged their attention in the practical sessions. In addition, audio-visual resources were generated for practical teaching in subsequent courses.
El microlearning ha sido utilizado como herramienta docente en un proyecto de innovación que se realizó con los alumnos de la asignatura Microbiología I del grado de Veterinaria de la Universidad de Murcia. Los estudiantes guiados por su profesora elaboraron píldoras formativas (videos de entre 2-5 minutos de duración) de las sesiones prácticas de la asignatura. Las píldoras formativas, una vez revisadas y corregidas, fueron publicadas en una cuenta privada de la famosa red social Instagram. Con posterioridad, las píldoras formativas pasaron por un proceso de selección por parte de los estudiantes y de la docente. La mejor píldora formativa de cada sesión práctica fue publicada en la herramienta Galería Multimedia, del Aula Virtual de la asignatura, generándose un recurso didáctico elaborado íntegramente por y para los estudiantes de esta asignatura. Se consiguió una participación del 95% de los estudiantes, un 65% manifestó haber elaborado una o más píldoras formativas, pero estas fueron visualizadas por casi la totalidad de los matriculados. El proyecto de innovación tuvo muy buena acogida por parte de los estudiantes, consiguió motivarlos en su proceso de aprendizaje e incentivar su atención en las sesiones prácticas. Además, se generaron recursos audiovisuales útiles para la docencia práctica en cursos posteriores.
Grain market and its role in ensuring Russia's national Security
Authors: Makhotina Irina Alekseevna , Agapkin Aleksandr Matveevich , Goncharenko Oksana Anatol'evna , Raikova Elena Yur'evna 
Published: December 2022

The subject of the study is the grain market of Russia and the EAEU as one of the priorities in the field of national security. The problem of illegal export of grain crops from Russia to Kazakhstan is considered. The article analyzes the issue of re-export of grain to third countries, illegal grain exports and the impact of quotas and tariff restrictions on the development of grain supplies abroad. The issue of the possibility of administering grain export bans with a high length of the Russian border, as well as the impact of such bans on the EAEU member states, is discussed. Particular attention is paid to the issue of changing the structure of grain exports and the search for new export directions. The novelty of the study lies in the analysis of the issue of ensuring the country's food security in retrospect of interaction with the EAEU member states. The current statistical data on the availability of farmland and arable land per capita in the world and in the EAEU countries are presented, data on the structure of acreage and grain production in Russia and the EAEU over the past three years are summarized. Forecasts for the volume of grain production and exports in 2022 are presented. The article analyzes the trend of increasing quotas and tariff restrictions for exporters of agro-industrial products and the impact of these restrictions on the country's food security. The issue of searching for new importing countries of agricultural products from Russia in the context of increasing sanctions is being considered. The problems of the grain market, which have worsened due to the current geopolitical situation, and ways to solve these problems at the state level are identified. The question was raised about the need to change the ratio of the shares of processed products and raw materials in the export structure, in the direction of increasing the volume of grain products with added value, whose share in the current structure of grain exports is less than 30%. Recommendations for improving the transparency and stability of the grain market are proposed.
Intelligent planning for large‐scale multi‐agent systems
Authors: Ma Hang 
Published: December 2022

AbstractThis article summarizes the New Faculty Highlights talk with the same title at AAAI 2021. Intelligent agents such as different types of robots will soon become an integral part of our daily lives. In real‐world multi‐agent systems, the most fundamental challenges are assigning tasks to multiple agents (task‐level coordination problems) and planning collision‐free paths for the agents to task locations (motion‐level coordination problems). This article surveys four directions of our research on using intelligent planning techniques for the above multi‐agent coordination problems. Link to video abstract: https://youtu.be/HDAFcatq9_I
Chlorogenic Acid‐Conjugated Nanoparticles Suppression of Platelet Activation and Disruption to Tumor Vascular Barriers for Enhancing Drug Penetration in Tumor
Authors: Ke Yue , Ma Zhifang , Ye Hongbo , Guan Xinghua , Xiang Zehong , Xia Yu , Shi Qiang 
Published: December 2022

AbstractHypercoagulation threatens the lives of cancer patients and cancer progression. Platelet overactivation attributes to the tumor‐associated hypercoagulation and maintenance of the tumor endothelial integrity, leading to limited intratumoral perfusion of nanoagents into solid tumors in spite of the enhanced penetration and retention effect (EPR). Therefore, the clinical application of nanotherapeutics in solid cancer still faces great challenges. Herein, this work establishes platelet inhibiting nanoagents based on FeIII‐doped C3N4coloaded with the chemotherapy drug and the antiplatelet drug chlorogenic acid (CA), further opening tumor vascular endothelial junctions, thereby disrupting the tumor vascular endothelial integrity, and enhancing drug perfusion. Moreover, CA not only damages the cancer cells but also potentiates the cytotoxicity induced by the chemotherapy drug doxorubicin, synergistically ablating the tumor tissue. Further, the introduction of CA relieves the original causes of the hypercoagulable state such as tissue factor (TF), thrombin, and matrix metalloproteinases (MMPs) secreted by cancer cells. It is anticipated that the hypercoagulation‐ and platelet‐inhibition strategy by integration of phenolic acid CA into chemotherapy provides insights into platelet inhibition‐assisted theranostics based on nanomedicines.
High‐Performance Self‐Powered Photodetectors with Space‐Confined Hybrid Lead Halide Perovskite Nanocrystals
Authors: Liu Yizhen , Gong Wenxiao , Xiang Fei , Li Yulan , Guo Heng , Hao Feng , Niu Xiaobin 
Published: December 2022

AbstractHybrid lead halide perovskites are widely studied in photodetectors due to their excellent optoelectronic properties. However, most of the perovskite photodetectors require an external power source, which adds additional costs and limits their application. Here, a self‐powered photodetector based on the heterojunction formed by methylammonium lead tribromide perovskite nanocrystals (MAPbBr3 NCs) and mesoporous TiO2 (m‐TiO2) is demonstrated by a space‐confined growth method. The NCs are uniformly grown on the m‐TiO2 framework and mirco‐heterojunctions are formed. Systematic research shows that the built‐in electric field of the mirco‐heterojunctions increases the exciton dissociation and carrier transport. In the absence of an external power supply, the photodetectors display an impressive on/off ratio (>105) and high detectivity (>1011 Jones) under 100 mW cm−2 solar irradiation. In addition, the winning device shows excellent long‐term stability (photocurrent maintains over 92% after exposure of 102 days to the air), benefiting from the enhanced binding energy and reduced defect density of NCs. It is believed that this study sheds light on the further development of self‐powered perovskite‐based photodetectors with high performance.
Achieving Simultaneously Ultrahigh Brightness, Extremely Low Efficiency Roll‐Off and Ultralong Lifetime of Blue Fluorescent OLEDs by Using Donor–Acceptor‐Type 5,9‐Diarylamine Functionalized Pyrenes
Authors: Xie Fuli , Yang Xilin , Jin Pengcheng , Wang Xiao‐Tian , Ran Huijuan , Zhang Hailu , Sun Huaming , Su Shi‐Jian , Hu Jian‐Yong 
Published: December 2022

AbstractIn this study, four new donor–acceptor (DA)‐type blue emitters (Py(5,9)BDPA, Py(5,9)BMTBA, Py(5,9)BDTBA, and Py (5,9)BTTBA) are developed by adopting benzene ring as A units and the diphenylamine (DPA) with different electron‐donating substituents as D units connected to 1,3‐positions and 5,9‐positions of pyrene ring, respectively. Gratifyingly, single‐crystal X‐ray analysis of the compounds demonstrates that the disgusting excimers in solid‐state could be effectively inhibited by the D units even the unsubstituted DPA resorting to the superiority of introducing D‐units at the 5,9‐positions of pyrene. The corresponding doped devices display ultrahigh luminance and extremely low efficiency roll‐off characteristics, especially for Py(5,9)BDPA, a roll‐off of external quantum efficiency is less than 4.9% when the luminance is up to 30 000 cd m−2, also showing good operation stability of devices. The optimized advanced device of the representative blue emitter Py(5,9)BDPA with a low manufacturing cost achieves extremely long LT95 (lifetime to 95% of the initial luminance) of 74 and 534 h at an initial luminance of 3000 and 1000 cd m−2, respectively. The ultralong lifetime of the emitter Py(5,9)BDPA is eye‐catching in the reported blue OLED lifetime and further demonstrates the practical applications in display and lighting of these DA‐type pyrene‐based blue emitters.
An Optogenetic‐Controlled Cell Reprogramming System for Driving Cell Fate and Light‐Responsive Chimeric Mice
Authors: Wang Meiyan , Liu Yuanxiao , Wang Ziwei , Qiao Longliang , Ma Xiaoding , Hu Lingfeng , Kong Deqiang , Wang Yuan , Ye Haifeng 
Published: December 2022

AbstractPluripotent stem cells (PSCs) hold great promise for cell‐based therapies, disease modeling, and drug discovery. Classic somatic cell reprogramming to generate induced pluripotent stem cells (iPSCs) is often achieved based on overexpression of transcription factors (TFs). However, this process is limited by side effect of overexpressed TFs and unpredicted targeting of TFs. Pinpoint control over endogenous TFs expression can provide the ability to reprogram cell fate and tissue function. Here, a light‐inducible cell reprogramming (LIRE) system is developed based on a photoreceptor protein cryptochrome system and clustered regularly interspaced short palindromic repeats/nuclease‐deficient CRISPR‐associated protein 9 for induced PSCs reprogramming. This system enables remote, non‐invasive optogenetical regulation of endogenous Sox2 and Oct4 loci to reprogram mouse embryonic fibroblasts into iPSCs (iPSCLIRE) under light‐emitting diode‐based illumination. iPSCLIRE cells can be efficiently differentiated into different cells by upregulating a corresponding TF. iPSCLIRE cells are used for blastocyst injection and optogenetic chimeric mice are successfully generated, which enables non‐invasive control of user‐defined endogenous genes in vivo, providing a valuable tool for facile and traceless controlled gene expression studies and genetic screens in mice. This LIRE system offers a remote, traceless, and non‐invasive approach for cellular reprogramming and modeling of complex human diseases in basic biological research and regenerative medicine applications.
Loss‐of‐Function of p21‐Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects
Authors: Wang Yan , Zhang Kaifan , Guo Jin , Yang Shuyan , Shi Xiaohui , Pan Jinrong , Sun Zheng , Zou Jizhen , Li Yi , Li Yuanyuan , Fan Tianda , Song Wei , Cheng Fang , Zeng Cheng , Li Jinchen , Zhang Ting , Sun Zhong Sheng 
Published: December 2022

AbstractClosure of the neural tube represents a highly complex and coordinated process, the failure of which constitutes common birth defects. The serine/threonine kinase p21‐activated kinase 2 (PAK2) is a critical regulator of cytoskeleton dynamics; however, its role in the neurulation and pathogenesis of neural tube defects (NTDs) remains unclear. Here, the results show that Pak2−/− mouse embryos fail to develop dorsolateral hinge points (DLHPs) and exhibit craniorachischisis, a severe phenotype of NTDs. Pak2 knockout activates BMP signaling that involves in vertebrate bone formation. Single‐cell transcriptomes reveal abnormal differentiation trajectories and transcriptional events in Pak2−/− mouse embryos during neural tube development. Two nonsynonymous and one recurrent splice‐site mutations in the PAK2 gene are identified in five human NTD fetuses, which exhibit attenuated PAK2 expression and upregulated BMP signaling in the brain. Mechanistically, PAK2 regulates Smad9 phosphorylation to inhibit BMP signaling and ultimately induce DLHP formation. Depletion of pak2a in zebrafish induces defects in the neural tube, which are partially rescued by the overexpression of wild‐type, but not mutant PAK2. The findings demonstrate the conserved role of PAK2 in neurulation in multiple vertebrate species, highlighting the molecular pathogenesis of PAK2 mutations in NTDs.
Current Progress on Methods and Technologies for Catalytic Methane Activation at Low Temperatures
Authors: Nkinahamira François , Yang Ruijie , Zhu Rongshu , Zhang Jingwen , Ren Zhaoyong , Sun Senlin , Xiong Haifeng , Zeng Zhiyuan 
Published: December 2022

AbstractMethane (CH4) is an attractive energy source and important greenhouse gas. Therefore, from the economic and environmental point of view, scientists are working hard to activate and convert CH4 into various products or less harmful gas at low‐temperature. Although the inert nature of CH bonds requires high dissociation energy at high temperatures, the efforts of researchers have demonstrated the feasibility of catalysts to activate CH4 at low temperatures. In this review, the efficient catalysts designed to reduce the CH4 oxidation temperature and improve conversion efficiencies are described. First, noble metals and transition metal‐based catalysts are summarized for activating CH4 in temperatures ranging from 50 to 500 °C. After that, the partial oxidation of CH4 at relatively low temperatures, including thermocatalysis in the liquid phase, photocatalysis, electrocatalysis, and nonthermal plasma technologies, is briefly discussed. Finally, the challenges and perspectives are presented to provide a systematic guideline for designing and synthesizing the highly efficient catalysts in the complete/partial oxidation of CH4 at low temperatures.
Filarial infections in lemurs: Evidence for a wide geographical distribution and low host specificity among lemur species
Authors: Kiene Frederik , Springer Andrea , Andriatsitohaina Bertrand , Ramsay Malcolm S. , Rakotondravony Romule , Strube Christina , Radespiel Ute 
Published: December 2022

AbstractThe relevance of emerging infectious diseases continues to grow worldwide as human activities increasingly extend into formerly remote natural areas. This is particularly noticeable on the island of Madagascar. As closest relatives to humans on the island, lemurs are of particular relevance as a potential origin of zoonotic pathogen spillover. Knowledge of pathogens circulating in lemur populations is, however, very poor. Particularly little is known about lemur hemoparasites. To infer host range, ecological and geographic spread of the recently described hemoparasitic nematode Lemurfilaria lemuris in northwestern Madagascar, a total of 942 individuals of two mouse lemur species (Microcebus murinus [n = 207] and Microcebus ravelobensis [n = 433]) and two rodent species (the endemic Eliurus myoxinus [n = 118] and the invasive Rattus rattus [n = 184]) were captured in two fragmented forest landscapes (Ankarafantsika National Park and Mariarano Classified Forest) in northwestern Madagascar for blood sample examination. No protozoan hemoparasites were detected by microscopic blood smear screening. Microfilaria were present in 1.0% (2/207) of M. murinus and 2.1% (9/433) of M. ravelobensis blood samples but not in rodent samples. Internal transcribed spacer 1 (ITS‐1) sequences were identical to an unnamed Onchocercidae species previously described to infect a larger lemur species, Propithecus verreauxi, about 650 km further south. In contrast to expectations, L. lemuris was not detected. The finding of a pathogen in a distantly related host species, at a considerable geographic distance from the location of its original detection, instead of a microfilaria species previously described for one of the studied host species in the same region, illustrates our low level of knowledge of lemur hemoparasites, their host ranges, distribution, modes of transmission, and their zoonotic potential. Our findings shall stimulate new research that will be of relevance for both conservation medicine and human epidemiology.