bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microliter Scale Synthesis of Luciferase‐Encapsulated Polymersomes as Artificial Organelles for Optogenetic Modulation of Cardiomyocyte Beating
Authors: Kim Hyemin , Yeow Jonathan , Najer Adrian , Kit‐Anan Worrapong , Wang Richard , Rifaie‐Graham Omar , Thanapongpibul Chalaisorn , Stevens Molly M. 
Published: July 2022

AbstractConstructing artificial systems that effectively replace or supplement natural biological machinery within cells is one of the fundamental challenges underpinning bioengineering. At the sub‐cellular scale, artificial organelles (AOs) have significant potential as long‐acting biomedical implants, mimicking native organelles by conducting intracellularly compartmentalized enzymatic actions. The potency of these AOs can be heightened when judiciously combined with genetic engineering, producing highly tailorable biohybrid cellular systems. Here, the authors present a cost‐effective, microliter scale (10 µL) polymersome (PSome) synthesis based on polymerization‐induced self‐assembly for the in situ encapsulation of Gaussia luciferase (GLuc), as a model luminescent enzyme. These GLuc‐loaded PSomes present ideal features of AOs including enhanced enzymatic resistance to thermal, proteolytic, and intracellular stresses. To demonstrate their biomodulation potential, the intracellular luminescence of GLuc‐loaded PSomes is coupled to optogenetically engineered cardiomyocytes, allowing modulation of cardiac beating frequency through treatment with coelenterazine (CTZ) as the substrate for GLuc. The long‐term intracellular stability of the luminescent AOs allows this cardiostimulatory phenomenon to be reinitiated with fresh CTZ even after 7 days in culture. This synergistic combination of organelle‐mimicking synthetic materials with genetic engineering is therefore envisioned as a highly universal strategy for the generation of new biohybrid cellular systems displaying unique triggerable properties.
Digital Light 3D Printed Bioresorbable and NIR‐Responsive Devices with Photothermal and Shape‐Memory Functions
Authors: Paunović Nevena , Marbach Jessica , Bao Yinyin , Berger Valentine , Klein Karina , Schleich Sarah , Coulter Fergal Brian , Kleger Nicole , Studart André R. , Franzen Daniel , Luo Zhi , Leroux Jean‐Christophe 
Published: July 2022

AbstractDigital light processing (DLP) 3D printing is a promising technique for the rapid manufacturing of customized medical devices with high precision. To be successfully translated to a clinical setting, challenges in the development of suitable photopolymerizable materials have yet to be overcome. Besides biocompatibility, it is often desirable for the printed devices to be biodegradable, elastic, and with a therapeutic function. Here, a multifunctional DLP printed material system based on the composite of gold nanorods and polyester copolymer is reported. The material demonstrates robust near‐infrared (NIR) responsiveness, allowing rapid and stable photothermal effect leading to the time‐dependent cell death. NIR light‐triggerable shape transformation is demonstrated, resulting in a facilitated insertion and expansion of DLP printed stent ex vivo. The proposed strategy opens a promising avenue for the design of multifunctional therapeutic devices based on nanoparticle–polymer composites.
An Oxygen Vacancy Memristor Ruled by Electron Correlations
Authors: Humbert Vincent , El Hage Ralph , Krieger Guillaume , Sanchez‐Santolino Gabriel , Sander Anke , Collin Sophie , Trastoy Juan , Briatico Javier , Santamaria Jacobo , Preziosi Daniele , Villegas Javier E. 
Published: July 2022

AbstractResistive switching effects offer new opportunities in the field of conventional memories as well as in the booming area of neuromorphic computing. Here the authors demonstrate memristive switching effects produced by a redox‐driven oxygen exchange in tunnel junctions based on NdNiO3, a strongly correlated electron system characterized by the presence of a metal‐to‐insulator transition (MIT). Strikingly, a strong interplay exists between the MIT and the redox mechanism, which on the one hand modifies the MIT itself, and on the other hand radically affects the tunnel resistance switching and the resistance states' lifetime. That results in a very unique temperature behavior and endows the junctions with multiple degrees of freedom. The obtained results bring up fundamental questions on the interplay between electronic correlations and the creation and mobility of oxygen vacancies in nickelates, opening a new avenue toward mimicking neuromorphic functions by exploiting the electric‐field control of correlated states.
In Situ Integrating Highly Ionic Conductive LDH‐Array@PVA Gel Electrolyte and MXene/Zn Anode for Dendrite‐Free High‐Performance Flexible Zn–Air Batteries
Authors: Hui Xiaobin , Zhang Peng , Li Jiafeng , Zhao Danyang , Li Zhaoqiang , Zhang Zhiwei , Wang Chengxiang , Wang Rutao , Yin Longwei 
Published: July 2022

AbstractLow interfacial ion transfer kinetics and structure instability of solid‐state electrolytes are the bottleneck which seriously limits the working life and energy density of flexible zinc–air batteries (ZABs). Herein, an optimized electrode–electrolyte integrated MXene/Zn‐layered double hydroxides (LDH)‐array@PVA structure is developed via an electrochemical Zn deposition, in situ LDH growth, polymer infiltration, and crosslinking route, integrating anode and gel polymer electrolyte (GPE) for high‐performance flexible ZABs. The highly orientated hydrophilic CoNi‐LDH arrays sufficiently crosslink with poly(vinyl alcohol) (PVA) chains, which effectively decreases the crystallinity degree of the PVA polymer and provides fast ionic diffusion channels to reduce the ionic transport barrier, endowing LDH‐array@PVA GPE with significantly improved ionic conductivity, water retention capability, and mechanical flexibility. Moreover, the optimized anode‐GPE integrated interface of MXene/Zn‐LDH‐array@PVA demonstrates excellent interfacial compatibility and stability, effectively reduces the interfacial impedance, and promotes the interfacial ionic transfer kinetics, enhancing a uniform zinc deposition without dendrite formation. The optimized ionic transfer kinetics and stable anode‐GPE integrated interface bring the MXene/Zn‐LDH‐array@PVA‐based flexible ZAB a long cycling life up to 50 h, and a high power density of 92.3 mW cm−2. The rationally designed in situ crosslinking and integration strategies provide enlightening pathways for the design of high‐performance flexible ZABs.
N‐Type Conductive Small Molecule Assisted 23.5% Efficient Inverted Perovskite Solar Cells
Authors: Cao Qi , Li Yuke , Zhang Yixin , Zhao Junsong , Wang Tong , Yang Bowen , Pu Xingyu , Yang Jiabao , Chen Hui , Chen Xingyuan , Li Xiaoqiang , Ghasemi Shahnaz , Salari Hadi , Hagfeldt Anders , Li Xuanhua 
Published: July 2022

AbstractBecause of the compatibility with tandem devices and the ability to be manufactured at low temperatures, inverted perovskite solar cells have generated far‐ranging interest for potential commercial applications. However, their efficiency remains inadequate owing to various traps in the perovskite film and the restricted hole blocking ability of the electron transport layer. Thus, in this work, a wide‐bandgap n‐type semiconductor, 4,6‐bis(3,5‐di(pyridin‐4‐yl)phenyl)‐2‐phenylpyrimidine (B4PyPPM), to modify a perovskite film via an anti‐solvent method is introduced. The nitrogen sites of pyrimidine and pyridine rings in B4PyPPM exhibit strong interactions with the undercoordinated lead ions in the perovskite material. These interactions can reduce the trap state densities and inhibit nonradiative recombination of the perovskite bulk. Moreover, B4PyPPM can partially aggregate on the perovskite surface, leading to an improvement in the hole‐blocking ability at its interface. This modification can also increase the built‐in potential and upshift the Fermi level of the modified perovskite film, promoting electron extraction to the electron transport layer. The champion device achieves a high efficiency of 23.51%. Meantime, the sealed device retains ≈80% of its initial performance under a maximum power point tracking for nearly 2400 h, demonstrating an excellent operational stability.
Excess PbI2 Management via Multimode Supramolecular Complex Engineering Enables High‐Performance Perovskite Solar Cells
Authors: Zhang Hengkai , Yu Wei , Guo Junxue , Xu Chao , Ren Zhiwei , Liu Kuan , Yang Guang , Qin Minchao , Huang Jiaming , Chen Zhiliang , Liang Qiong , Shen Dong , Wu Zehan , Zhang Yaokang , Chandran Hrisheekesh Thachoth , Hao Jianhua , Zhu Ye , Lee Chun‐sing , Lu Xinhui , Zheng Zijian , Huang Jinsong , Li Gang 
Published: July 2022

AbstractExcess PbI2 in perovskite film is an effective strategy for boosting perovskite solar cells (PSCs) performance. However, the presence of unreacted PbI2 is a critical source of intrinsic instability in perovskite under illumination, due to the photolysis of PbI2 (decomposed into metallic lead and iodine). Herein, this issue is solved by applying ionic liquids (ILs) on PSCs where the ILs can form types of stable supramolecules with residual lead iodide. The formation process and mechanism of the supramolecules are elucidated. The residual PbI2 is also revealed to cause high level lead interstitial defects and induced tensile strain which further deteriorate device performance. The self‐assembled supramolecular complex can passivate the PSCs where significant enhancements are achieved in both power conversion efficiency (PCE, from 21.9% to 23.4%) and device stability (retaining 95% of the initial PCE after 4080 h in ambient dry‐air storage, and 80% after 1400 h continuous light illumination).
Recycling Strategies for Solid Oxide Cells
Authors: Sarner Stephan , Schreiber Andrea , Menzler Norbert H. , Guillon Olivier 
Published: July 2022

AbstractAlongside the generation of renewable power and its storage in batteries, hydrogen technologies are essential to enable a deep decarbonization of the energy system. These technologies include solid oxide cells (SOCs), which can be operated as electrolyzers to generate hydrogen or syngas and/or for power supply in fuel cell mode and demonstrate the highest electrical efficiency among electrochemical converters. However, SOCs like other energy technologies contain significant amounts of critical raw materials, which should be preserved appropriately. Therefore, the development of economically viable recycling strategies is required even at an early market entry stage. In this paper, potential recycling routes for SOC stack components are discussed. Based on state‐of‐the‐art materials and cell designs, the future challenges related to SOC recycling are outlined, and possible recycling pathways for all SOC components are presented with an emphasis on the ceramic fractions. Their economic and environmental potentials are evaluated, showing the significant advantages offered by recycling.
Profiling of bioactive compounds and antioxidant activity of aquatic weedIpomoea aquatica
Authors: Roy Sajal , Zilani Md. Nazmul Hasan , Alrashada Yousof Naser , Islam Mohammed Monirul , Akhe Fatema Kamrunnaher , Uddin SK Jamal , Sarower Md Golam 
Published: July 2022

AbstractWater spinach,Ipomoea aquatica, is a common semi‐aquatic weed that is used as an ingredient in fish feed to support its growth and defence system. The present study aimed to identify and quantify bioactive polyphenols through HPLC‐DAD (High Performance Liquid Chromatograpgy ‐ Diode Array Detector) analysis and to evaluate the antioxidant activity of the aquatic weedI. aquaticaavailable in Bangladesh. Different bioactive phytochemical groups were qualitatively appraised in crude ethanol extract, aqueous andn‐hexane fractions of water spinach. The total polyphenol and flavonoids content were spectrophotometrically discerned using Folin–Chiocalteu and aluminium chloride, respectively. Bioactive compounds of the extracts were identified by the HPLC‐DAD method. Furthermore, 2,2‐diphenyl‐1‐picryldydrazyl (DPPH) and hydroxyl‐radical scavenging and reducing power assays were followed to assess antioxidant activity. The experimental extracts confirmed the presence of different bioactive phytochemical groups. The crude extract contained the highest content of both polyphenol (94.93 mg gallic acid (GA) equivalent per gram dry extract) and flavonoids (373.30 mg quercetin equivalent per gram dry extract). Besides, in HPLC (High Performance Liquid Chromatogrphy) analysis, ellagic acid was present at the highest concentration both in crude (337.26 mg/100 g dry extract) and aqueous (280.06 mg/100 g dry extract) extracts. However, then‐hexane fraction only contained GA (13.91 mg/100 g dry extract). Also, some other bioactive polyphenols were identified in crude and aqueous fraction extracts. The crude extract revealed superior antioxidant activity in DPPH (Half maximal inhibitory Concentration (IC50) = 149.30 ± 1.43 μg/ml) and hydroxyl radical scavenging assays (IC50 = 327.257 ± 1.36 μg/ml) in comparison to the rest of the extracts. Furthermore, all of the extracts showed dose‐dependent reducing power activity. HPLC‐identified bioactive compounds may be responsible for antioxidant activity. Because of these identified compounds,I. aquaticaholds the potential feed ingredient in aquaculture.
Effects of supplemental L‐methionine for total replacement of fish meal by soybean meal on growth, feed utilisation and health status of stinging catfish, Heteropneustes fossilis fry
Authors: Billah Sheikh Masum , Sumi Kanij Rukshana , Howlader Sumon , Sarkar Subroto , Ferdous Zannatul , Islam S.M. Majharul , Shahjahan Md 
Published: July 2022

AbstractA 14‐week feeding trial was conducted to evaluate the effect of supplemental L‐methionine for total replacement of fish meal (FM) with soybean meal (SBM) on growth and feed utilisation of the stinging catfish, Heteropneustes fossilis. Five diets were formulated, where Diet 1 contained 15% FM and 45% SBM as a source of protein. The other four diets (2–5) contained 0% FM and around 60% SBM (59.5%, 59.0%, 58.5% and 58.0% SBM, respectively) with various percentages (0.5%, 1.0%, 1.5% and 2%) of L‐methionine. The significantly highest mean final weight (g), weight gain (g), percent weight gain (%) and specific growth rate (% day−1) were found in Diet 4 containing 58.5% SBM with 1.5% L‐methionine, and there was no significant difference between Diets 1 and 4. The feed conversion ratio (FCR), protein efficiency ratio (PER) and survival rate did not differ significantly among fish groups. However, the best FCR and higher PER were found in Diet 4. The whole‐body carcass protein was significantly lower in Diets 2 and 5, which contained 0.5% and 2% L‐methionine, respectively, and might be below or above the requirements of stinging catfish. Significantly higher lipid content was found in Diets 2 and 4. Dietary 1.5% supplementation of L‐methionine for total replacement of FM with SBM increased haemoglobin, red blood cells, white blood cells and blood glucose, and 2% supplementation of L‐methionine decreased these values significantly. Moreover, considerable morphological improvement of the intestine was observed in Diet 4. Therefore, the results suggest that Diet 4 containing 58.5% SBM with 1.5% supplemental L‐methionine could completely replace FM without adverse effects on growth, feed utilisation and health condition of stinging catfish, H. fossilis.
Biomass yield and biofiber properties of select industrial fiber crops in Lithuania
Authors: Bakšinskaitė Aušra , Tilvikiene Vita , Doyeni ModupeOlufemi 
Published: July 2022

AbstractThe versatility, flexibility, design, and lightness of plastic are the most attractive features that enable its useability in our daily life. As production of disposable plastic increases, so does the amount of waste. Plastic waste is nondegradable. Its accumulation over time increases the risk of environmental pollution and contributes to environmental hazards. This has resulted into finding more renewable sources that could replace plastics. One renewable resource is agricultural plant biomass rich in cellulose. This work is aimed at evaluating the chemical composition and structure of industrial fiber crops. Three types of crops were selected: Miscanthus (Miscanthus giganteus), Virginia mallow (Sida hermaphrodita Rusby), and mugwort (Artemisia dubia Wall.). Their properties were compared with wheat straw (Triticum spp.). The industrial fiber crops and wheat straw were fertilized with mineral fertilizer at 90 kg ha−1. Experiments were performed to evaluate chemical and physical composition and biofiber parameters of crops. The highest cellulose content of 54.5 ± 2.17% was in mugwort with the lowest value of 42.5 ± 1.31% in Miscanthus. The carbon/nitrogen (C/N) ratio was the lowest in mugwort (114.8 ± 3.91%). This means mugwort biomass can be easily degraded by microorganisms and has better biomass pretreatment properties. The best fiber quality was found in Virginia mallow. However, the yield of Miscanthus fiber per hectare was higher, compared with other tested crops. The study presented opportunities for mugwort and Miscanthus as verifiable industrial fiber crops. They hold huge potential as raw materials for biorefinery production with less cost and high productivity under temperate climatic conditions.
Supporting immigrant caregivers during the COVID‐19 pandemic: Continuous adaptation and implementation of an early childhood digital engagement program
Authors: Rojas Natalia M. , Katter Julie , Tian Ran , Montesdeoca Jacqueline , Caycedo Camila , Kerker Bonnie D. 
Published: July 2022

AbstractDigital messaging programs have the potential to be a powerful, low‐cost, technological tool to support multiple facets of caregivers' knowledge, and implementation of developmentally appropriate caregiver‐child activities among diverse immigrant populations. However, involving caregivers and community stakeholders in the cultural and linguistic tailoring of interventions to optimize utilization and engagement may be critical to ensuring messaging programs' usability and acceptability. The purpose of this mixed‐method study was to use the dynamic adaptation process (DAP) within an Exploration, Preparation, Implementation, Sustainment (EPIS) framework to examine the implementation of a digital messaging program, developed at the beginning of the COVID‐19 pandemic, aimed at providing Spanish‐, English‐, and Mandarin‐speaking immigrant caregivers with caregiver‐child activities that supported children's development and caregivers' knowledge. Building upon the EPIS framework, using DAP, we assessed the feasibility and acceptability of a messaging program via short message service or multimedia message service, WeChat, and Remind and webinar program during the COVID‐19 pandemic. The study illustrated how a digital messaging program is a feasible mechanism for sharing developmentally and culturally appropriate information with immigrant caregivers. In addition, the use of the DAP and the EPIS framework allowed us to continuously track the process of cultural adaptation, identify barriers and facilitators of the outreach program, and examine how implementation unfolded across all three groups of caregivers.
An evaluation of a rapid conversion to teleSANE in response to COVID‐19
Authors: Shaw Jessica , Feeney Hannah , Meunier‐Sham Joan , Hazard Karen , Plante Pamela , Petricone Randi 
Published: July 2022

AbstractSexual Assault Nurse Examiners (SANEs) provide expert, comprehensive medical forensic care to patients who present for services following a sexual assault. Because SANEs are not consistently available, telehealth technology is being explored as a means to provide access to this expert care (i.e., teleSANE). During the COVID‐19 pandemic, teleSANE offered additional potential benefits by reducing the length of time spent and number of providers in patient exam rooms, the need for personal protective equipment that was in high demand and short supply, and provider anxiety related to providing in‐person care. In the summer of 2020, the Massachusetts SANE program rapidly and temporarily converted five hospitals from in‐person SANE care to teleSANE. An evaluation team interviewed 23 providers using a rapid research and evaluation methods approach to assess the temporary model and inform the future of SANE care. Evaluation findings reveal it is possible to rapidly and temporarily convert hospitals from in‐person to teleSANE care in a time of broad uncertainty, and that such a change requires intensive and thoughtful planning; a shared commitment to being supportive, flexible, and responsive; and specific experience and expertise. Considerations for communities exploring how best to ensure consistent, equitable access to SANEs are discussed.
Cardiovascular disease risk factors distribution and clustering across different geographic levels in Nepal
Authors: Ghimire Umesh , Yasmin Sabina , Chand Swati , Timalsena Birat Krishna , Bhat Tikendra , Thapa Sangharsha , Ranabhat Kamal , Paudel Kiran , Shah Sangam 
Published: July 2022

AbstractBackgroundIn an effort to reduce the burgeoning problem of cardiovascular diseases (CVD), it is imperative to understand the variation of risk factors across different geographic regions. This study aims to shed light on examining the leading risk factors of CVD and it's clustering across Nepal.MethodsData from a nationally representative survey were analyzed to estimate the distribution of four major risk factors (high blood pressure, overweight, obesity, and smoking) of cardiovascular diseases. Similarly, this study also assessed the intra‐cluster correlation coefficients (ICCs) of CVD risk factors at the household, community (urban/rural), district, and province level.ResultsThis study included 14 418 adult population with age of 15 years and above of which 41.7% were male and 58.3% were female. Higher prevalence of all four CVD risk factors was found in the richest quintile, people living in hilly region, most noticeably among residents of metropolitan city and in Gandaki, Bagmati, and Province 1. The ICC decreased as the socio‐geographic clustering units decreased in size from province, district, and household level clustering. The ICC was highest at province level for “province 1” for raised blood pressure than other provinces.ConclusionsRisk factors of CVD in Nepal are concentrated prominent in highly urbanized areas and ICC is low as the level of geography decreased from province, district, and household. The findings can be applied in directing prevention activities at different levels to mitigate the higher burden of risk factors of CVD in Nepal.