bluuebunny/crossref_metadata_2025_split huggingface dataset:
Counseling and social justice advocacy interventions with refugees: Two case studies
Authors: Kondili Elvita , Interiano‐Shiverdecker Claudia , Hahn Crystal 
Published: July 2022

AbstractThe Multicultural and Social Justice Counseling Competencies (MSJCCs) illustrate the need for counselors to act as social justice advocates. The significant influx of refugees in the United States and the sociopolitical nature of their resettlement necessitate practical multicultural and social justice counseling competencies. Using two case studies, the authors apply the four levels and four competencies of the MSJCCs and provide multicultural and social justice interventions on three levels: interpersonal, community, and public policy.
Relationship of herpesvirus (HSV1, EBV, CMV, HHV6) seropositivity with depressive disorder and its clinical aspects: The first study in children
Authors: Bayturan Semra , Sapmaz Şermin Yalın , Uzun Aylin Deniz , Kandemir Hasan , Ecemiş Talat 
Published: July 2022

AbstractInfections can lead to the onset of mood disorders in adults, partly through inflammatory mechanisms. However pediatric data are lacking. The aim of this study is to evaluate the relationship between depressive disorder and seropositivity of herpes virus infections in children.The sample group consisted of patients diagnosed with depressive disorder according to DSM‐5 diagnostic criteria and healthy volunteers, being between 11 and 18 years with clinically normal mental capacity. All children completed DSM‐5‐Level‐2 Depression Scale, DSM‐5‐Level‐2 Irritability Scale, DSM‐5‐Level‐2 Sleep Scale, DSM‐5‐Level‐2 Somatic Symptoms Scale. The levels of anti‐HSV1‐IgG, anti‐CMV‐IgG, anti‐EBNA, and anti‐HHV6‐IgG were examined in all participants. Patients with an antibody value above the cut‐off values specified in the test kits were evaluated as seropositive. The mean age was 15.54 ± 1.57 years in the depression group (DG), 14.87 ± 1.76 years in the healthy control group (CG). There were 4 boys (11.2%), 32 girls (88.8%) in the DG, 9 boys (21.9%) and 32 girls (78.04%) in the CG. There was no statistically significant difference between the groups in terms of the presence of seropositivity of HSV1, CMV, EBV, and HHV6. HHV6 antibody levels were significantly higher in the DG (p = 0.000). A significant positive correlation was found between HHV6 antibodies and DSM‐5 level‐2 somatic symptoms scale score. HHV6 antibody levels were found to be significantly higher in patients with existing suicidal ideation in the DG (n = 13) compared to those without existing suicidal ideation in the DG (p = 0.043). HHV6 persistent infections may be responsible for somatic symptoms and etiology of suicidal ideation in childhood depressive disorder.
Extensive open lobectomy experience is not a prerequisite for learning uniportal video‐assisted thoracic surgery lobectomy
Authors: Zhai Rong , Liu He , Wang Jian , Shan Limei , Luo Ming , Yao Fei 
Published: July 2022

AbstractBackground and objectivesUniportal video‐assisted thoracoscopic surgery (U‐VATS) lobectomy has been increasingly adopted to manage early stage lung cancer. However, little information is available on whether this technique can be taught to surgeons inexperienced in open lobectomy. This study aimed to investigate the learning curve for U‐VATS lobectomy performed by a single surgeon with limited open lobectomy experience.MethodsFrom July 2018 to September 2020, 103 patients received U‐VATS lobectomy for lung cancer by a single surgeon. The learning curve was assessed using three statistical methods: the moving average analysis, cumulative sum (CUSUM) analysis, and risk‐adjusted CUSUM (RA‐CUSUM) analysis.ResultsThe moving average analysis showed a continuous decrease in operative time throughout the study period. The CUSUM analysis demonstrated three well‐differentiated learning phases: Phase 1 (the initial 34 cases) representing the initial learning, Phase 2 (the middle 33 cases) representing the improvement of competence, and Phase 3 (the final 36 cases) representing technical proficiency. RA‐CUSUM analysis revealed that the maximized cumulative surgical failure, defined as the maximum cumulative difference between the observed and predicted surgical failures, was found in the 61st case.ConclusionsU‐VATS lobectomy is feasible for surgeons with limited open lobectomy experience. Multidimensional statistical analyses suggested that 61–67 cases were required to gain technical proficiency and ensure acceptable surgical outcomes.
Characterization and determination of benvitimod, an unknown risk substance in cosmetics, using nuclear magnetic resonance spectroscopy and HPLC‒MS/MS
Authors: Wang Xinran , Wang Haiyan , Wu Xianfu , Lu Yong 
Published: July 2022

Ultrahigh‐performance liquid chromatography‐tandem high‐resolution mass spectrometry, combined with preparative chromatography and nuclear magnetic resonance spectroscopy, a new method for identifying unknown risk substance structures in cosmetics has been established. Moreover, HPLC‒MS/MS was developed for the determination of benvitimod in cosmetics. The sample was collected in ultrahigh‐performance liquid chromatography–tandem high‐resolution mass spectrometry, and the molecular formula of the unknown was obtained as C17H18O2. After preparative chromatography enrichment and purification, the enriched compound was scanned by nuclear magnetic resonance spectroscopy, and the chemical structure of the unknown compound was confirmed to be benvitimod. Subsequently, the separation was determined in multiple reaction monitoring mode. The results showed that the linearity of benvitimod was good in the range of 1–100 μg/L with a correlation coefficient r2 > 0.999; the limits of detection and quantification were 0.02 mg/kg and 0.067 mg/kg; the precision and stability were good; and the average recoveries were 104.2%, 108.2%, and 108.7% for low, medium, and high spiked concentrations, respectively. Forty batches of cosmetics were screened, of which two batches were detected with the illegal addition of benvitimod at 2.48 and 3.13 g/kg. The method effectively solved the loopholes in regulation and provided a research basis for the qualitative identification of structurally unknown compounds in cosmetics.
An analysis of publishing studies journals: An insight into the structure of the field based on publications
Authors: Augustyn Kamila 
Published: July 2022

AbstractAlthough interest in publishing studies is increasing, the academic status of PS is still uncertain. The aim of this work is to provide insight into the structure of the field by naming its core journals, determining the size of the research community and degree of collaboration, identifying the most relevant authors and institutions and answering the question as to whether PS is more academically or professionally oriented. This paper uses Scopus data and VOSviewer software to illustrate similarities between journals, authors and countries based on bibliographic coupling, co‐authorship, citation and co‐citation analysis. Eight journals representing various publishing sectors (trade, education, scholarly and professional publishing) were identified as the main sources of PS articles. They differ in their frequency of publication, number of citations, visibility in bibliographic databases, the percentage of co‐authored articles and the affiliation structure of the authors. Nine percent of authors out of 3370 unique authors form the publishing studies research community, with 1%–3% being identified as the key authors. The researchers worked mainly alone or in collaboration with one or two partners. Analysis of the authors' affiliations and a co‐citation analysis of source titles confirm strong PS research connections with the publishing industry.
Relative perfusion index: An objective, quantitative and noninvasive method for evaluating the severity of keloids
Authors: Li Shuo , Zhang Mingzi , Long Xiao , Wang Xiaojun 
Published: July 2022

AbstractBackgroundKeloids are the result of abnormal wound healing, and they differ from the normal skin of the patient in the level of blood perfusion and the degrees of inflammation, hypoxia, regeneration of vessels, and expression of sensory receptors. However, there is no objective assessment method to accurately characterize the severity of keloids.ObjectivesThe purpose of this study was to evaluate the perfusion levels of keloids and the expression levels of various internal cytokines, including hypoxia‐induced factor‐1α (HIF‐1α), vascular endothelial growth factor (VEGF), interleukin‐17 (IL‐17), HT2A receptor subtype (5‐HT2AR), and H1R, in keloids and nonadjacent normal skin and to propose a laser speckle contrast imaging (LSCI)‐based relative perfusion index (RPI), through which keloids can be divided into five grades to objectively characterize their severity.MethodsThis population‐based cross‐sectional study included 70 untreated keloid patients who each had only one keloid on the chest. LSCI was used to measure the area of each patient's keloid () and the perfusion level of each patient's keloid () and normal skin (). The Vancouver Scar Scale (VSS) and Visual Analog Scale (VAS) for pain and pruritus were also used to assess each keloid. Immunohistochemistry and Western blot were used to detect the expression levels of various internal cytokines in keloids and normal skin. We compared the perfusion and expression levels of intrinsic cytokines between keloids and normal skin. We established the RPI to grade the severity of keloids and applied different methods to test the utility of the RPI.ResultsThe mean perfusion level of keloids was significantly higher than that of normal skin (p < 0.001). The expression levels of HIF‐1α, VEGF, IL‐17, 5‐HT2AR, and H1R in keloids were significantly higher than those in normal skin (p < 0.05). RPI was defined as: The severity of keloids could be divided into five grades based on RPI. The RPI had a higher correlation with the pain‐VAS, pruritus‐VAS, and the expression levels of internal cytokines in keloids than blood perfusion levels and the VSS. T‐SNE (t‐distributed stochastic neighbor embedding) was also used to verify the clinical discriminatory abilities of this RPI model.ConclusionsThe proposed RPI based on LSCI showed the highest accuracy, unlike the VSS and assessment of perfusion, and can be utilized as a reliable, objective, quantitative, and noninvasive tool to evaluate the severity of keloids.
Synthesis and Morphology of High‐Molecular‐Weight Polyisobutylene–Polystyrene Block Copolymers Containing Dynamic Covalent Bonds
Authors: Mehringer Kyle D. , Davis Brad J. , Kemp Lisa K. , Ma Guorong , Hunt Samuel B. , Storey Robson F. , Gu Xiaodan , Thornell Travis L. , Wedgeworth Dane N. , Simon Yoan C. , Morgan Sarah E. 
Published: July 2022

AbstractIncorporating dynamic covalent bonds into block copolymers provides useful molecular level information during mechanical testing, but it is currently unknown how the incorporation of these units affects the resultant polymer morphology. High‐molecular‐weight polyisobutylene‐b‐polystyrene block copolymers containing an anthracene/maleimide dynamic covalent bond are synthesized through a combination of postpolymerization modification, reversible addition–fragmentation chain‐transfer polymerization, and Diels–Alder coupling. The bulk morphologies with and without dynamic covalent bond are characterized by atomic force microscopy and small‐angle X‐ray scattering, which reveal a strong dependence on annealing time and casting solvent. Morphology is largely unaffected by the inclusion of the mechanophore. The high‐molecular‐weight polymers synthesized allow interrogation of a large range of polymer domain sizes.
What are we imaging? Software tools and experimental strategies for annotation and identification of small molecules in mass spectrometry imaging
Authors: Baquer Gerard , Sementé Lluc , Mahamdi Toufik , Correig Xavier , Ràfols Pere , García‐Altares María 
Published: July 2022

AbstractMass spectrometry imaging (MSI) has become a widespread analytical technique to perform nonlabeled spatial molecular identification. The Achilles' heel of MSI is the annotation and identification of molecular species due to intrinsic limitations of the technique (lack of chromatographic separation and the difficulty to apply tandem MS). Successful strategies to perform annotation and identification combine extra analytical steps, like using orthogonal analytical techniques to identify compounds; with algorithms that integrate the spectral and spatial information. In this review, we discuss different experimental strategies and bioinformatics tools to annotate and identify compounds in MSI experiments. We target strategies and tools for small molecule applications, such as lipidomics and metabolomics. First, we explain how sample preparation and the acquisition process influences annotation and identification, from sample preservation to the use of orthogonal techniques. Then, we review twelve software tools for annotation and identification in MSI. Finally, we offer perspectives on two current needs of the MSI community: the adaptation of guidelines for communicating confidence levels in identifications; and the creation of a standard format to store and exchange annotations and identifications in MSI.
Density functional theory calculations of δ(13C) and δ(1H) chemical shifts and 3J(13COO1H) coupling constants as structural and analytical tools in hydroperoxides: Prospects and limitations of 1H13C heteronuclear multiple bond correlation experiments
Authors: Ahmed Raheel , Siskos Michael G. , Siddiqui Hina , Gerothanassis Ioannis P. 
Published: July 2022

AbstractDensity functional theory (DFT) calculations of δ(13C) and δ(1H) chemical shifts and 3J(13COO1H) coupling constants of three model hydroperoxides of the naturally occurring cis‐11‐OOH and trans‐9‐OOH isomers of oleate and 9‐cis, 11‐trans‐16‐OOH endo hydroperoxide of methyl linolenate are reported. The computational δ(OOH) for various functionals and basis sets were found to be nearly identical for the cis/trans geometric isomers. The chemical shifts of the methine CHOOH protons and carbons, on the contrary, are highly diagnostic for the identification of cis/trans geometric isomerism. The chemical shifts of the olefinic protons and carbons strongly depend on the orientation of the hydroperoxide unit relative to the double bond and, thus, of importance in conformational analysis. The results are in very good agreement with the available experimental data. For the various diastereomeric pairs of the model endo‐hydroperoxide, the strongly deshielded OOH resonances, due to the presence of an intramolecular hydrogen bond between the hydroperoxide proton and an oxygen of the endo‐peroxide ring, along with the δ(CHOOH), are highly diagnostic for identification and structure elucidation of complex erythro‐ and threo‐ diastereomeric pairs of endo‐hydroperoxides; the computational results are in very good agreement with the available experimental data. The 3J(13COO1H) coupling constants were found to be <
Hz for the cis–trans geometric models and <
Hz for the endo‐hydroperoxide and, thus, unimportant in stereochemical analysis. Sharp resonances of the hydroperoxide protons, with Δν1/2 < 3 Hz, are required for the successful implementation of the 1H13C heteronuclear multiple bond correlation (HMBC) technique.
Impact of germ cell ablation on the activation of the brain–pituitary–gonadal axis in precocious Atlantic salmon (Salmo salar L.) males
Authors: Tveiten Helge , Karlsen Kristian , Thesslund Tina , Johansson Gunhild S. , Thiyagarajan Dhivya B. , Andersen Øivind 
Published: July 2022

AbstractThe germ cells are essential for sexual reproduction by giving rise to the gametes, but the importance of germ cells for gonadal somatic functions varies among vertebrates. The RNA‐binding dead end (Dnd) protein is necessary for the specification and migration of primordial germ cells to the future reproductive organs. Here, we ablated the gametes in Atlantic salmon males and females by microinjecting dnd antisense gapmer oligonucleotides at the zygotic stage. Precocious maturation was induced in above 50% of both germ cell‐depleted and intact fertile males, but not in females, by exposure to an off‐season photoperiod regime. Sterile and fertile males showed similar body growth, but maturing fish tended to be heavier than their immature counterparts. Pituitary fshβ messenger RNA levels strongly increased in maturing sterile and fertile males concomitant with the upregulated expression of Sertoli and Leydig cell markers. Plasma concentrations of 11‐ketotestosterone and testosterone in maturing sterile males were significantly higher than the basal levels in immature fish, but lower than those in maturing fertile males. The study demonstrates that germ cells are not a prerequisite for the activation of the brain–pituitary–gonad axis and sex steroidogenesis in Atlantic salmon males, but may be important for the maintenance of gonadal somatic functions.
Progression of Ouali model by the strengthening and percolating efficacies of interphase for polymer halloysite nanotubes composites applicable in the biomedical products
Authors: Zare Yasser , Rhee Kyong Yop 
Published: July 2022

AbstractThe Ouali model is used to approximate the tensile strength of a halloysite nanotube (HNT) system after the start of percolation. The proposed model reflects the interphase and its roles in the percolation start and strengthening of samples. The outputs of the proposed model are matched to tested data, and the impressions of all parameters on the strength of the samples are evaluated. Experimentally measured results of numerous examples as well as parametric studies validate the established model. The strength of the nanocomposite is directly associated with the depth (t) and strength (σi) of the interphase section. At t = 5 nm, the strength of the system improves by 6%, whereas at t = 40 nm, the strength of the nanocomposite increases by 46%. At σi = 50 MPa, the strength of the samples increases by 5%, whereas at σi = 400 MPa, it increases by 35%. Furthermore, the results show an inverse correlation between the strength of the system and the HNT radius. The HNT concentration directly affects the strength, and at an HNT volume portion of 0.04, the strength of the nanocomposite increases significantly by 78%. Nonetheless, the percolation start and HNT length do not significantly affect the strength of the nanocomposites. The present samples can be applied in the biomedical fields, due to their excellent properties.
Preparation and evaluation of modified bisphenol‐A‐glycidyl methacrylate resin dental adhesive to zirconia
Authors: Wang Yuhe , Luo Shao‐Hua , Zhang Xian , Wang Zihan , Qi Hongfei , Yan Shengxue , Wang Xuan , Wang Luoxuan , Wu Haiyan , Chen Yingying 
Published: July 2022

AbstractIn recent years, zirconia repair materials have developed rapidly and are now widely used in the preparation of dental restorations such as crowns, veneers, and bridges. Zirconium oxide has excellent mechanical properties and excellent biocompatibility. However, the inertness of itself determined that it cannot bond well with dental hard tissue, and the high volume shrinkage of the adhesive also results in poor bonding. In this article, bisphenol‐A‐glycerol dimethacrylate (Bis‐GMA) was acetylated, and a light curing acrylate‐based adhesive with high bonding strength was prepared. The volume shrinkage of the adhesive prepared by modified Bis‐GMA decreased, the shear bonding strength increased, and the double‐bond conversion and thermal stability of the adhesive were improved. This article compares the self‐prepared adhesive with the Single Bond Universal produced by 3M and All‐Bond Universal produced by Bisco. The results show that the self‐prepared adhesives are superior to the two commercial adhesives in terms of shear bonding strength, water absorption value, solubility value, and volume shrinkage.
School wellbeing and psychological characteristics of online learning in families of children with and without hearing loss during the Covid‐19 pandemic
Authors: Inguscio Bianca Maria Serena , Nicastri Maria , Giallini Ilaria , Greco Antonio , Babiloni Fabio , Cartocci Giulia , Mancini Patrizia 
Published: July 2022

AbstractThis study investigated the psychological characteristics of online learning on Italian students with and without hearing loss (HL) and on their parents, who were forced into isolation during the Covid‐19 pandemic. An online survey collected information on socio‐demographic data and opinions concerning online learning from 61 children (mean age 11; 25 males, 36 females), including 43 with HL and also from their parents; additionally, school wellbeing and anxiety were assessed. The results showed that, in both the student and parent groups, no significant effect of HL on school wellbeing and anxiety was found. Additionally, in parents, State Anxiety was significantly higher than Trait Anxiety, suggesting one possible impact of lockdown on psychological wellbeing. Differences due to HL were observed and discussed in correlation analyses. The Authors believe that this study is the first contribution to the psychological evaluation of the impact of online learning on families with hearing‐impaired children, from the perspective of a successful, inclusive didactic.
Introductory Notes on Non‐linear Electrodynamics and its Applications
Authors: Sorokin Dmitri P. 
Published: July 2022

AbstractIn 1933‐1934 Born and Infeld constructed the first non‐linear generalization of Maxwell's electrodynamics that turned out to be a remarkable theory in many respects. In 1935 Heisenberg and Euler computed a complete effective action describing non‐linear corrections to Maxwell's theory due to quantum electron‐positron one‐loop effects. Since then, these and a variety of other models of non‐linear electrodynamics proposed in the course of decades have been extensively studied and used in a wide range of areas of theoretical physics including string theory, gravity, cosmology and condensed matter (CMT). In these notes I will overview general properties of non‐linear electrodynamics and particular models which are distinguished by their symmetries and physical properties, such as a recently discovered unique non‐linear modification of Maxwell's electrodynamics which is conformal and duality invariant. I will also sketch how non‐linear electromagnetic effects may manifest themselves in physical phenomena (such as vacuum birefringence), in properties of gravitational objects (e.g. charged black holes) and in the evolution of the universe, and can be used, via gravity/CMT holography, for the description of properties of certain conducting and insulating materials.