bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model analysis of energy consumption data for green building using deep learning neural network
Authors: Yu Mingyu , Li Lihong , Guo Zhenxu 
Published: January 2022

Abstract
The purposes are to solve the defects of traditional backpropagation neural network (BPNN), such as inclined local extremum and slow convergence, as well as the incomplete data acquisition of building energy consumption (EC). Firstly, a green building (GB)-oriented EC data generation model based on generative adversarial networks (GANs) is implemented; GAN can learn the hidden laws of raw data and produce enhanced virtual data. Secondly, the GB-oriented EC prediction model based on Levenberg Marquardt-optimized BPNN is implemented and used for building EC prediction. Finally, the effectiveness of the proposed model is verified by real building EC data. The results show that the data enhanced by the GAN model can reduce the model prediction error; the optimized BPNN model has lower prediction error and better performance than other models. The purpose of this study is to provide important technical support for the improvement and prediction of GB energy data.
Description of novel microsatellite markers for the giant mud crab Scylla serrata (Forskål, 1775) (Decapoda: Brachyura: Portunidae), with an evaluation for applications in stock structure and parentage assignment
Authors: Renshaw Mark A , Delos Santos Miguel A , Moss Dustin R 
Published: January 2022

Abstract
The giant mud crab, Scylla serrata (Forskål, 1775), is a targeted fishery along its geographic distribution, both for domestic and international markets. Population genetic data, evaluated with genetic markers such as microsatellites, can be used to identify management units (stocks) based on genetic dissimilarities between locations, informing localized management decisions for targeted fisheries. Additionally, microsatellite loci can be used to identify released individuals from stock enhancement programs, while simultaneously monitoring genetic impacts of hatchery-releases on wild populations. We isolated and characterized 16 novel microsatellite markers; fourteen of the markers were further evaluated for population structure among three localities in the US-Affiliated Pacific Islands: Palau, Pohnpei, and Kosrae. The significant genetic differentiation observed between Palau and Kosrae/Pohnpei suggests the newly described markers would be capable of elucidating structure across the broader scope of the geographic distribution of the species. Given the international trade for live mud crab, the evaluation of structure would highlight potential issues regarding the transport of live animals between locations with genetically differentiated stocks. Additionally, a multilocus exclusion probability of 0.999, with as few as three markers, suggests the novel microsatellite markers would be capable of identifying hatchery-sourced individuals as part of a stock enhancement program.
Spatiotemporal Distribution of Two Euschistus spp. Stink Bugs (Hemiptera: Pentatomidae) in Southeastern Farmscapes
Authors: Grabarczyk Erin E , Mizell Russell F , Greene Jeremy K , Herzog Gary A , Tillman P Glynn , Cottrell Ted E 
Published: January 2022

Abstract
Stink bugs (Hemiptera: Pentatomidae) are ubiquitous, cryptic, phytophagous pests that are found in many crops. In agroecosystems, individuals disperse from adjacent noncrop hosts and tend to aggregate or cluster within fields. In this study, we characterized the distribution of Euschistus servus (Say) and Euschistus tristigmus (Say) (Hemiptera: Pentatomidae) over 2 yr at three southeastern United States farmscapes. Stink bugs were captured in pheromone-baited traps, and Spatial Analysis by Distance Indices (SADIE) used to identify the location of significant aggregations by habitat type and season. Euschistus servus adults were more likely to be captured in pecan orchards, cotton, other crops, or unmanaged habitats than in woodland habitats. Significant aggregations of E. servus were detected in a variety of habitats including pecan, corn, cotton, peanut, and tobacco, as well as fallow and hay fields, pastures, and hedgerows. Fewer adult E. tristigmus were captured than E. servus adults, and E. tristigmus adults were typically trapped and aggregated in woodland habitats. The resulting data provide an important understanding regarding the seasonal movement and relative abundance levels of stink bug populations, which are critical to the development of integrated pest management strategies.
Post-cholecystectomy clip migration—a unique method of retrieval
Authors: Aaron Ezekiel , Palamuthusingam Pranavan 
Published: January 2022

Abstract
Post-cholecystectomy clip migration with formation of bile duct stones is a known but rare complication of laparoscopic cholecystectomy. This report discusses the case of a 64-year-old lady who presented with biliary colic symptoms 12 years post laparoscopic cholecystectomy. Computed tomography of the abdomen demonstrated one surgical clip located in the distal common bile duct, with a bile stone formed around it. This was removed via ERCP with spyglass cholangioscopy and lithotripsy.
The obliterated ureteric orifice: a nightmare for the pelvic surgeon or a routine-job for the endo-urologist? Case report of a standardized endoscopic approach
Authors: Balakrishnan Sahana S , Kailavasan Mithun M , Alevizopoulos Aristeidis A 
Published: January 2022

Abstract
We present the endoscopic management of two cases of complete ureteric occlusion at vesico-ureteral junction (VUJ) level following iatrogenic injury. Case 1 is a 60-year-old man who developed bilateral ureteric injury at the level of the VUJ following robot-assisted radical prostatectomy (RARP) for Gleason 3 + 4 = 7 T2bN0 prostate cancer. Case 2 is an 81-year-old man with history of recurrent G2pTa transitional cell carcinoma of the bladder originally diagnosed in 2005 and history of radical radiotherapy for prostate cancer. At his most recent transurethral resection of bladder tumour, the left ureteric orifice was not visualized. We describe step-by-step our technique in restoring continuity of the ureter with minimally invasive endoscopic approach, resulting in excellent long-term upper tract drainage for our patients. To our knowledge, combined utilization of a Collins knife to incise the area around the ureteric orifice to unearth them is not reported. We aim to report our technique and its outcomes.
Clinical observations of osteoporosis in Japanese patients with rheumatoid arthritis
Authors: Furuya Takefumi 
Published: January 2022

ABSTRACT
Osteoporosis is one of the major adverse outcomes in patients with rheumatoid arthritis (RA). Recently, we and others have been reported many clinical observations related to osteoporosis in Japanese RA patients. In this article, I reviewed these findings. Japanese patients with RA have a 2-fold risk of fractures compared with those without RA. Among the fractures in Japanese RA patients, three-quarters of the fractures were non-vertebral fractures. The incidence of non-vertebral fractures did not change, despite an improvement in RA disease activity. Older age, female gender, history of fractures, history of total knee replacements, disease activity scores in 28 joints (DAS28), health assessment questionnaire disability index (HAQ-DI), low bone mineral density, glucocorticoid dose, and vitamin D deficiency were significantly associated with fractures. Older age, high body mass index (BMI), HAQ-DI, and polypharmacy were significantly associated with falls. BMI (both overweight and underweight), DAS28, and HAQ-DI were significantly associated with frailty. Half and three-quarters of Japanese men and women with RA had vitamin D deficiency, respectively. The incidence of osteonecrosis of the jaw may be higher in Japanese RA patients than in those without RA. Undertreatment of osteoporosis appears to exist in Japanese patients with RA.
Mitochondrial DNA copy number as a prognostic marker is age-dependent in adult glioblastoma
Authors: Sourty Baptiste , Dardaud Laure-Marie , Bris Céline , Desquiret-Dumas Valérie , Boisselier Blandine , Basset Laëtitia , Figarella-Branger Dominique , Morel Alain , Sanson Marc , Procaccio Vincent , Rousseau Audrey 
Published: January 2022

Abstract

Background
Glioblastoma (GBM) is the most common and aggressive form of glioma. GBM frequently displays chromosome (chr) 7 gain, chr 10 loss and/or EGFR amplification (chr7+/chr10-/EGFRamp). Overall survival (OS) is 15 months after treatment. In young adults, IDH1/2 mutations are associated with longer survival. In children, histone H3 mutations portend a dismal prognosis. Novel reliable prognostic markers are needed in GBM. We assessed the prognostic value of mitochondrial DNA (mtDNA) copy number in adult GBM.

Methods
mtDNA copy number was assessed using real-time quantitative PCR in 232 primary GBM. Methylation of POLG and TFAM genes, involved in mtDNA replication, was assessed by bisulfite-pyrosequencing in 44 and 51 cases, respectively.

Results
Median age at diagnosis was 56.6 years-old and median OS, 13.3 months. 153/232 GBM (66 %) displayed chr7+/chr10-/EGFRamp, 23 (9.9 %) IDH1/2 mutation, 3 (1.3 %) H3 mutation and 53 (22.8 %) no key genetic alterations. GBM were divided into two groups, “Low” (n = 116) and “High” (n = 116), according to the median mtDNA/nuclear DNA ratio (237.7). There was no significant difference in OS between the two groups. By dividing the whole cohort according to the median age at diagnosis, OS was longer in the “High” vs “Low” subgroup (27.3 vs 15 months, P = .0203) in young adult GBM (n = 117) and longer in the “Low” vs “High” subgroup (14.5 vs 10.2 months, P = .0116) in older adult GBM (n = 115). POLG was highly methylated, whereas TFAM remained unmethylated.

Conclusion
mtDNA copy number may be a novel prognostic biomarker in GBM, its impact depending on age.
Understanding the Emergence of Extreme Right Parties in Portugal in the Late 2010s
Authors: Carvalho João 
Published: January 2022

Abstract
After more than four decades of immunity to the extreme-right party family, this Portuguese exceptionalism came to an end after the electoral breakthrough of the Chega party in the 2019 general elections. Drawing on a case study approach, this article discusses different explanations for the timing of Chega’s emergence in Portuguese mainstream politics in the late 2010s. Considering this late success, Portugal can be seen as a crucial case study to assess the available theories. This investigation employs a popular schema that implies the distinction between explanations focused on ‘demand-side’ factors (the protest voting thesis and the public salience of immigration) from those concerned with ‘supply-side’ factors (the spatial competition theory and internal supply factors). Through the employment of the congruence method, this article highlights the interaction between party-centric factors as a more appropriate explanation for understanding the timing of Chega’s electoral breakthrough than demand-side approaches.
Anandamide Hydrolysis Inhibition Reverses the Long-Term Behavioral and Gene Expression Alterations Induced by MK-801 in Male Rats: Differential CB1 and CB2 Receptor-Mediated Effects
Authors: Bauminger Hagar , Zaidan Hiba , Akirav Irit , Gaisler-Salomon Inna 
Published: January 2022

Abstract
NMDA receptor blockade in rodents is commonly used to induce schizophrenia-like behavioral abnormalities, including cognitive deficits and social dysfunction. Aberrant glutamate and GABA transmission, particularly in adolescence, is implicated in these behavioral abnormalities. The endocannabinoid system modulates glutamate and GABA transmission, but the impact of endocannabinoid modulation on cognitive and social dysfunction is unclear. Here, we asked whether late-adolescence administration of the anandamide hydrolysis inhibitor URB597 can reverse behavioral deficits induced by early-adolescence administration of the NMDA receptor blocker MK-801. In parallel, we assessed the impact of MK-801 and URB597 on mRNA expression of glutamate and GABA markers. We found that URB597 prevented MK-801-induced novel object recognition deficits and social interaction abnormalities in adult rats, and reversed glutamate and GABA aberrations in the prelimbic PFC. URB597-mediated reversal of MK-801-induced social interaction deficits was mediated by the CB1 receptor, whereas the reversal of cognitive deficits was mediated by the CB2 receptor. This was paralleled by the reversal of CB1 and CB2 receptor expression abnormalities in the basolateral amygdala and prelimbic PFC, respectively. Together, our findings show that interfering with NMDA receptor function in early adolescence has a lasting impact on phenotypes resembling the negative symptoms and cognitive deficits of schizophrenia and on glutamate and GABA marker expression in the PFC. Prevention of behavioral and molecular abnormalities by late-adolescence URB597 via CB1 and CB2 receptors suggests that endocannabinoid stimulation may have therapeutic potential in addressing treatment-resistant symptoms.
Activation of canonical inflammasome complex by acute silica exposure in experimental rat model
Authors: Niu Yingmei , Yang Shuangli , Hu Xiumei 
Published: January 2022

Abstract
Silicosis is a chronic irreversible pulmonary disease caused by the inhalation of silica crystals in occupational settings in most cases. Persistent inflammation in the alveolar space is considered to be the major reason for tissue damage and lung fibrogenesis. The mechanisms by which silica exposure activates immune cells are not well understood. Here, we employed an in vivo silicosis disease model by intratracheal instillation of a large dose of silica suspension in rats and explored the involvement of inflammasome activation. Marked leukocyte infiltration and edema were observed 3 days following silica exposure in treated animals compared to controls. Using this model, we compared the expression of inflammasome sensors (AIM2 and NLRP3) and effector protein (caspase-1) by western blot and immunohistochemical staining using the lung homogenates and lung tissue sections. Our results demonstrated that following acute silica exposure, AIM2, NLRP3 and caspase-1 expressions were increased in macrophages or/and lung epithelial cells compared to control animals. We also analyzed interleukin 1β expression using lung homogenates, and significant increase in interleukin 1β was observed in 3-day silica-exposed rats. The activation of inflammasome sensors AIM2 and NLRP3 suggested to us that blocking these activators may attenuate silica-associated tissue damage and inflammation.
The skull of Sanajeh indicus, a Cretaceous snake with an upper temporal bar, and the origin of ophidian wide-gaped feeding
Authors: Zaher Hussam , Mohabey Dhananjay M , Grazziotin Felipe G , Wilson Mantilla Jeffrey A 
Published: January 2022

Abstract
Recent phylogenetic analyses differ in their interpretations of the origin and interrelationships of snakes, resulting in polarized views of snake ecology, habit and acquisition of features associated with wide-gaped feeding (macrostomy). Here, we report a new specimen of the Late Cretaceous nest predator Sanajeh indicus that helps to resolve the origin of macrostomy. The new specimen preserves an ossified upper temporal bar and a posteriorly expanded otooccipital region that lacks a free-ending supratemporal bone and retains a lizard-like palatomaxillary arch that allows limited movements during swallowing. Phylogenetic analyses of a large-scale total evidence dataset resolve Sanajeh near the base of Pan-Serpentes, as the sister group of Najash, Dinilysia and crown-group Serpentes. The Cretaceous Tetrapodophis and Coniophis represent the earliest-diverging members of Pan-Serpentes. The Cretaceous hindlimbed pachyophiids and Cenozoic Australian ‘madtsoiids’ are inside crown Alethinophidia, whereas mosasaurs are recovered invariably within anguimorphs. Our results suggest that the wide-gape condition in mosasaurs and snakes might have evolved independently, as functionally distinct mechanisms of prey ingestion. The intermediate morphology preserved in Sanajeh indicates that ingestion of large prey items (macrophagy) preceded wide-gaped, unilateral feeding (macrostomy), which appeared 35 Myr later, in the common ancestor of pachyophiids, Cenozoic Australian ‘madtsoiids’ and alethinophidians.
Aggressiveness of Small-Spored Alternaria spp. and Their Sensitivity to Succinate Dehydrogenase Inhibitor Fungicides
Authors: Budde-Rodriguez Sarah , Pasche Julie S. , Shahoveisi Fereshteh , Mallik Ipsita , Gudmestad Neil C. 
Published: January 2022

Brown leaf spot of potato is caused by a number of small-spored Alternaria spp. Alternaria alternata sensu stricto, A. arborescens, and A. tenuissima have been reported with increasing frequency in commercial potato fields. Potato cultivars with resistance to small-spored Alternaria spp. have yet to be developed; therefore, the application of foliar fungicides is a primary management strategy. Greenhouse inoculation assays demonstrated that isolates of these three small-spored Alternaria spp. were pathogenic. Significant differences in aggressiveness were observed across isolates; however, there was no trend in aggressiveness based on species. Significant fungicide by isolate interactions in in vitro fungicide sensitivity and significant differences between baseline and nonbaseline isolates were observed in all three small-spored Alternaria spp. The ranges of in vitro sensitivity of A. alternata baseline isolates to boscalid (EC50 <0.010 to 0.89 µg/ml), fluopyram (<0.010 to 1.14 µg/ml) and solatenol (<0.010 to 1.14 µg/ml) were relatively wide when compared with adepidyn (<0.010 to 0.023 µg/ml). The baseline sensitivities of A. arborescens and A. tenuissima isolates to all four fungicides were <0.065 µg/ml. Between 10 and 21% of nonbaseline A. alternata isolates fell outside the baseline range established for the four succinate dehydrogenase inhibitor (SDHI) fungicides evaluated. In A. arborescens, 10 to 80% of nonbaseline isolates had higher sensitivities than the baseline. A. tenuissima isolates fell outside the baseline for boscalid (55%), fluopyram (14%), and solatenol (14%), but none fell outside the baseline range for adepidyn. Evaluations of in vivo fungicide efficacy demonstrated that most isolates were equally controlled by the four SDHI fungicides. However, reduced boscalid efficacy was observed for four isolates (two each of A. arborescens and A. tenuissima) and reduced fluopyram control was observed in one A. alternata isolate. Results of these studies demonstrate that isolates of all three species could be contributing to the brown leaf spot pathogen complex and that monitoring both species diversity and fungicide sensitivity could be advantageous for the management of brown leaf spot in potatoes with SDHI fungicides.
Identifying pediatric malnutrition using STRONGkids
Authors: Coop Kathryn , Potthoff Meghan 
Published: January 2022

Abstract:
Pediatric malnutrition can impact a patient's length of hospital stay, rates of infection and complications, cognitive development, and overall quality of life. This article compares nutritional screening tools to determine their efficiency and reliability in identifying patients with increased malnutrition risk at the time of hospital admission.
Strategies to improve nurses' stress response during the COVID-19 pandemic
Authors: Meehan Carolyn D. , Schlamb Cheryl D. , Nair Julie McCulloh 
Published: January 2022

Abstract:
Pandemic-related stress factors have been profoundly impacting the wellness of nurses, resulting in job burnout, moral distress, and some nurses deciding to leave the profession. This article examines strategies to identify stressors and develop self-care and coping skills.
Pediatric Osteoarticular Infections Caused by Mycobacteria Tuberculosis Complex: A 26-Year Review of Cases in San Diego, CA
Authors: Drobish Ian , Ramchandar Nanda , Raabe Vanessa , Pong Alice , Bradley John , Cannavino Christopher 
Published: January 2022

Background:
Osteoarticular infections (OAIs) account for 10%–20% of extrapulmonary Mycobacteria tuberculosis (MTB) complex infections in children and 1%–2% of all pediatric tuberculosis infections. Treatment regimens and durations typically mirror recommendations for other types of extrapulmonary MTB, but there are significant variations in practice, with some experts suggesting a treatment course of 12 months or longer.

Methods:
We conducted a retrospective review of children diagnosed with MTB complex OAI and cared for between December 31, 1992, and December 31, 2018, at a tertiary care pediatric hospital near the United States–Mexico border.

Results:
We identified 21 children with MTB complex OAI during the study period. Concurrent pulmonary disease (9.5%), meningitis (9.5%), and intra-abdominal involvement (14.3%) were all observed. MTB complex was identified by culture from operative samples in 15/21 children (71.4%); 8/15 (53.3%) cultures were positive for Mycobacterium bovis. Open bone biopsy was the most common procedure for procurement of a tissue sample and had the highest culture yield. The median duration of antimicrobial therapy was 52 weeks (interquartile range, 46–58). Successful completion of therapy was documented in 15 children (71.4%). Nine children (42.9%) experienced long-term sequelae related to their infection.

Conclusion:
Among the 21 children with MTB complex OAI assessed, 8 of 15 (53.3%) children with a positive tissue culture had M. bovis, representing a higher percentage than in previous reports and potentially reflecting its presence in unpasteurized dairy products in the California-Baja region. Bone biopsy produced the highest culture yield in this study. Given the rarity of this disease, multicenter collaborative studies are needed to improve our understanding of the presentation and management of pediatric MTB complex OAI.