bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posterior-stabilized total knee arthroplasty kinematics and joint laxity: A hybrid biomechanical study
Authors: Sekeitto Allan R. , McGale Jance G. , Montgomery Liam A. , Vasarhelyi Edward M. , Willing Ryan , Lanting Brent A. 
Published: December 2022

Abstract
Background
Posterior-stabilized (PS)-total knee arthroplasty (TKA) arose as an alternative to cruciate-retaining (CR)-TKA in the 1970s. Since then, it has become a popularly utilized TKA design with outcomes comparable to CR-TKA. The post-cam mechanism is unique to PS-TKA as it substitutes the function of the posterior cruciate ligament (PCL). The study aimed to understand the kinematic and laxity changes in PS-TKA with under- and overstuffing of the tibiofemoral joint space with the polyethylene (PE) insert.

Methods
This study employed a hybrid computational-experimental joint motion simulation on a VIVO 6 degrees of freedom (6-DoF) joint motion simulator (AMTI, Watertown, MA, USA). Physical prototypes of a virtually-performed TKA in mechanical alignment (MA) and kinematic alignment (KA) based on cadaveric CT scans and a virtual ligament model were utilized. The reference, understuffed (down 2 mm) and overstuffed (up 2 mm) joint spaces were simulated, neutral flexion and laxity testing loads and motions were performed for each configuration.

Results
The PE insert thickness influenced post-cam engagement, which occurred after 60º in the overstuffed configurations, after 60º–75º in the reference configurations and after 75º in the understuffed configurations. The understuffed configurations, compared to the reference configurations, resulted in a mean 2.0º (28%) and 2.0º (31%) increase in the coronal laxity in MA and KA respectively. The overstuffed configurations, compared to the reference configuration, resulted in an increase in the mean joint compressive forces (JCFs) by 73 N (61%) and 77 N (62%) in MA and KA models, respectively.

Conclusions
The under- and overstuffing in PS-TKA alter the kinematics with variable effects. Understuffing decreases the stability, JCFs and inverse with overstuffing. Subtle changes in the PE insert thickness alter the post-cam mechanics.
A case of SAPHO syndrome: a DISH of radiological features to be considered
Authors: Sabooniha Fakhreddin 
Published: December 2022

Abstract
Background
The acronym SAPHO stands for synovitis, acne, pustulosis, hyperostosis, and osteitis. It is a rare heterogenous disease with unknown etiology and a chronic relapsing and remitting course1. Its skin and osteoarticular manifestations including palmoplantar pustulosis (PPP) and synovitis may be transient which further complicate the diagnosis. So, awareness about all features of the syndrome throughout the time seems mandatory for correct diagnosis and avoidance of unnecessary procedures.
Case presentation.
A case of SAPHO syndrome being reported in a middle-aged man who presented with bilateral PPP and exacerbation of back pain which developed shortly after covid-19 vaccine injection with a history of more than 20 years of inflammatory thoracic back pain and psoriasis vulgaris who initially had been worked up for metastatic bony lesions based on radiologic studies, irrespective of his skin lesions. The patient had good response to alendronate 70 mg weekly and celecoxib 200 mg BID without aggravation of existing skin lesions or new psoriatic lesions.

Conclusion
This case report aims to inform rheumatologists and radiologists about various radiologic and dermatologic manifestations of SAPHO syndrome with emphasizing on taking into consideration of past and present skin lesions in the interpretation of the radiologic signs in order to prevent irrelevant procedures or hazardous imaging and to urge rheumatology societies to set up a SAPHO registry for future randomized controlled trials. Suggestion of PPP responsiveness to NSAIDs as a new potential diagnostic tool for SAPHO diagnosis is another goal. It also aims to point out the possible coexistence of SAPHO and SpA or DISH syndrome.
The role of Hedgehog and Notch signaling pathway in cancer
Authors: Xia Ruolan , Xu Maosen , Yang Jing , Ma Xuelei 
Published: December 2022

AbstractNotch and Hedgehog signaling are involved in cancer biology and pathology, including the maintenance of tumor cell proliferation, cancer stem-like cells, and the tumor microenvironment. Given the complexity of Notch signaling in tumors, its role as both a tumor promoter and suppressor, and the crosstalk between pathways, the goal of developing clinically safe, effective, tumor-specific Notch-targeted drugs has remained intractable. Drugs developed against the Hedgehog signaling pathway have affirmed definitive therapeutic effects in basal cell carcinoma; however, in some contexts, the challenges of tumor resistance and recurrence leap to the forefront. The efficacy is very limited for other tumor types. In recent years, we have witnessed an exponential increase in the investigation and recognition of the critical roles of the Notch and Hedgehog signaling pathways in cancers, and the crosstalk between these pathways has vast space and value to explore. A series of clinical trials targeting signaling have been launched continually. In this review, we introduce current advances in the understanding of Notch and Hedgehog signaling and the crosstalk between pathways in specific tumor cell populations and microenvironments. Moreover, we also discuss the potential of targeting Notch and Hedgehog for cancer therapy, intending to promote the leap from bench to bedside.
Immunotherapy and Biomarker Testing in Recurrent and Metastatic Head and Neck Cancers: ASCO Guideline
Authors: Yilmaz Emrullah , Ismaila Nofisat , Bauman Julie E. , Dabney Raetasha , Gan Gregory , Jordan Richard , Kaufman Marnie , Kirtane Kedar , McBride Sean Matthew , Old Matthew O. , Rooper Lisa , Saba Nabil F. , Sheth Siddharth , Subramaniam Rathan M. , Wise-Draper Trisha Michel , Wong Deborah , Mell Loren K. 
Published: December 2022

PURPOSE To provide evidence-based recommendations for practicing physicians and other health care providers on immunotherapy and biomarker testing for head and neck cancers. METHODS ASCO convened an Expert Panel of medical oncology, surgical oncology, radiation oncology, radiology, pathology, and patient advocacy experts to conduct a literature search, including systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 2000 through 2022. Outcomes of interest included survival, overall response, and locoregional control. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS The literature search identified 28 relevant studies to inform the evidence base for this guideline. RECOMMENDATIONS When possible, evidence-based recommendations were developed to address biomarker testing, first-line treatment regimens based on programmed death ligand-1 scores, immunotherapy in platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma, immunotherapy in nasopharyngeal carcinoma, and radiation therapy in combination with immunotherapy for treatment of local recurrence. Additional information is available at www.asco.org/head-neck-cancer-guidelines .
Reorienting Visual Reading
Authors: Mor Liron 
Published: December 2022

AbstractThis essay explores visual reading and its colonial aspects by analyzing the novel Ze ʿim ha-panim elenu (The One Facing Us, 1995), by Ronit Matalon, an Israeli Jewish author of Egyptian descent. In this novel Matalon displaces the dramas of Mizrahi Jews (Jews originating from the Arab and Muslim world) to Cameroon, thus stressing her protagonists’ uneasy positioning within the colonizer-colonized, West-East divides and connecting Zionist racialization to broader, global processes of colonial capitalism. By exploring her elaborate readings of photographs in the novel, the essay reveals two rival traditions of reading the visual: the first involves what might be described, following Matalon, as a certain “intending toward” the photograph—a colonial reading practice through which a subject converts her absence from the photographic moment into a visionary, intentional presence. In this Barthesian tradition, the image is an empty land to be colonized, and Oriental subjects are racialized by being fetishistically associated with both authentic matter and theological aura. The second tradition, typified in the novel by the protagonist’s Egyptian mother, is a laborious collective practice of reading photographs that is attentive to subtext, nonverbal communication, and social codes. The essay argues that this reading practice has nothing to do with postcolonial or Levantine hybridity or with a “migratory state of mind”—concepts that govern scholarship on Matalon—and that its subsistence requires in fact a solid, counterdiasporic sense of home.
Mapping health services for adults with cerebral palsy in Ireland: a pilot study
Authors: Manikandan Manjula , Jagdeo Shalini , Weldon Fiona , Harrington Sarah , O'Sullivan Rory , Fortune Jennifer , Kerr Claire , M Ryan Jennifer 
Published: December 2022

Background: Cerebral palsy (CP) is a common cause of physical disability in childhood. The majority of children with CP survive to adulthood. Once discharged from children’s services, adults with CP find it challenging to navigate health services. The aim of this study was to pilot and refine a methodology to map services for adults with CP in Ireland. Methods: We used a multi-informant mapping methodology consisting of: 1. Defining health services; 2. Identifying informants; 3. Designing a survey; 4. Collecting data; 5. Data checking and analysis. We collected data on services from service users and service providers using an online survey. We verified data against information available online and by asking organisations to provide details about the service. Results: Fifteen service users and nine service providers completed the online survey. Data on 265 unique services at 32 organisations were provided. The most commonly provided services were physiotherapy (12%) and occupational therapy (11%). We confirmed the name of 89 services (34%) against online information. We received further details from eight organisations about 27 services. Specifically, we received details about the organisation name for 27 of the 265 services (10%), service name for 25 services (9%), service type for 25 services (9%), a website for 19 services (7%), and data on eligibility criteria and types of supports provided for between 25 or 26 services (9% or 10%). Conclusion: This pilot study highlighted the complexity of mapping services for adults with CP in Ireland. We recommend that an alternative methodology should be used to map services for adults with CP in Ireland.
Bio-oil production from biogenic wastes, the hydrothermal conversion step
Authors: Haarlemmer Geert , Roubaud Anne 
Published: December 2022

Background: Food wastes are an abundant resource that can be effectively valorised by hydrothermal liquefaction to produce bio-fuels. The objective of the European project WASTE2ROAD is to demonstrate the complete value chain from waste collection to engine tests. The principle of hydrothermal liquefaction is well known but there are still many factors that make the science very empirical. Most experiments in the literature are performed on batch reactors. Comparison of results from batch reactors with experiments with continuous reactors are rare in the literature. Methods: Various food wastes were transformed by hydrothermal liquefaction. The resources used and the products from the experiments have been extensively analysed. Two different experimental reactors have been used, a batch reactor and a continuous reactor. This paper presents a dataset of fully documented experiments performed in this project, on food wastes with different compositions, conditions and solvents. The data set is extended with data from the literature. The data was analysed using machine learning analysis and regression techniques. Results: This paper presents experimental results on various food wastes as well as modelling and analysis with machine learning algorithms. The experimental results were used to attempt to establish a link between batch and continuous experiments. The molecular weight of bio-oil from continuous experiments appear higher than that of batch experiments. This may be due to the configuration of our reactor. Conclusions: This paper shows how the use of regression models help with understanding the results, and the importance of process variables and resource composition. A novel data analysis technique gives an insight on the accuracy that can be obtained from these models.
Aspek Yuridis Rencana Pembangunan Ibu Kota Baru Negara Indonesia di Kalimantan Timur dalam Perspektif Pembangunan Berkelanjutan
Authors: Heri Moh , Abdi Nurul Satria 
Published: December 2022

Rencana pembangunan ibu kota baru lazim di lakukan disebuah negara, tidak terkecuali di Negara Republik Indonesia. Akan tetapi yang menjadi problematika sekarang adalah, apakah rencana pembangunan ini sudah memenuhi prinsip-prinsip pembangunan berkelanjutan atau malah sebaliknya, yaitu merusak lingkungan hidup. Secara umum penelitian ini bertujuan untuk mengetahui aspek yuridis rencana pembanguan ibu kota baru negara Indonesia dan prinsip-prinsip yang harus di penuhi dalam rencana pembangunan ibu kota baru negara Indonesia. Penelitian ini ,mengunakan hukum yuridis normatif atau penelitian dogmatik, karena menganalisis suatu kaidah hukum atau norma hukum dalam koridor hukum positif atau peraturan perundang-undangan. Dari hasil penelitian ini rencana pembangunan ibu kota baru hanya fokus pada Pasal 7 ayat (1) sedangkan Pasal 6 ayat (2) dan Pasal 7 ayat (2) belum sepenuhnya terakomudi. Adapun prinsip-prinsp pembangunan berkelanjutan yang diakomodir meliputi, konsep smart city, green city, beautiful city, dan sutainable city. Sehingga ini belum mencerminkan keadilan antar generasi, keadilan dalam satu generasi, pencegahan dini, perlindungan hayati, internalisasi biaya lingkungan yang idealnya terakomudir dalam prinsip-prinsip pembangunan berkelanjutan.
Association between physical health and physical activity behaviors for children aged 3–6 years in kindergarten: A cross-sectional study from China
Authors: Xiong Xin , Zhang Weinan , An Yaqi , Meng Yunchen , Li Haifeng , Zhen Zhiping , Sun Jian 
Published: December 2022

Purpose
To explore the association between the physical health (PH) and physical activity behavior (PAB) of children aged 3 to 6 years, and to provide a basis for the scientific planning of children’s physical activity behavior in kindergarten.

Methods
A total of 18041 children in China aged 3 to 6 years were selected as the research subject. The PH monitoring indicators were measured according to "The National Physical Fitness Measurement Standards Manual" (Preschool Children Version) (NPFMSM), and PAB was reported by teachers. The chi-square test was used to test for differences in PH and PAB across groups, the percentile method was used to rank PAB, correlation analysis was used to analyze the association between components of PH and PAB, and multiple linear regression was used to determine the independent association between PAB and PH.

Results
Participants in this study exhibited poor PH status, and the detection rates of failure were 16.4% for boys and 16.8% for girls, and showed a decreasing trend with increasing age. The grade difference and sex difference in PH components were statistically significant (P<0.01). PAB changes to static activities with increasing age, mainly to static indoor physical activities (SIPAs). The regression effects of the total duration of physical activity (TDPA) and dynamic physical activity (DPA) on PH score and physical fitness (PF) score were significant (P < 0.01) but not statistically significant with static physical activity (SPA) (P>0.05). Dynamic outdoor physical activity (DOPA) is the core factor affecting children’s PH, and is significantly positively correlated with the components of PH.

Conclusion
PAB in kindergarten can improve children’s PH, and reasonable planning of PAB in kindergarten has a targeted effect on PH promotion.
Exploring the association between epilepsy and depression: A systematic review and meta-analysis
Authors: Qin Shao-kun , Yang Zi-xian , Guan Zhen-wei , Zhang Jin-hu , Ping Xin , Lu Ye , Pei Lin 
Published: December 2022

ObjectiveThis study offers meta-analytic data on the potential association between epilepsy and depression especially for the prevalence of depression in epilepsy or vice versa.MethodsThe relevant studies were searched and identified from nine electronic databases. Studies that mentioned the prevalence and/or incidence of epilepsy and depression were included. Hand searches were also included. The search language was English and the search time was through May 2022. Where feasible, random-effects models were used to generate pooled estimates.ResultsAfter screening electronic databases and other resources, 48 studies from 6,234 citations were included in this meta-analysis. The period prevalence of epilepsy ranged from 1% to 6% in patients with depression. In population-based settings, the pooled period prevalence of depression in patients with epilepsy was 27% (95% CI, 23–31) and 34% in clinical settings (95% CI, 30–39). Twenty studies reported that seizure frequency, low income, unemployment of the patients, perception of stigma, anxiety, being female, unmarried status, disease course, worse quality of life, higher disability scores, and focal-impaired awareness seizures were risk factors for depression.ConclusionOur study found that epilepsy was associated with an increased risk of depression. Depression was associated with the severity of epilepsy.
Analyzing online public commentary responding to the announcement of deemed consent organ donation legislation in the Canadian province of Nova Scotia
Authors: Marcon Alessandro R. , Wagner Darren N. , Rachul Christen , Weiss Matthew J. 
Published: December 2022

Background
The Canadian province of Nova Scotia recently became the first jurisdiction in North America to pass deemed consent organ donation legislation. The announcement of this legislation generated substantial online discussion, which we analyzed to provide insights on public perception.

Methods
We performed directed content analysis on 2663 user-generated comments appearing on two widely-shared Canadian Broadcasting Company (CBC) articles published online in April 2019. We determined levels of support and opposition in comments and described the specific rhetoric used for doing so. We also performed one-way ANOVA and Pearson chi-square tests to determine how the comments were being received and engaged by other users.

Results
A range of commentary was present in both support and opposition to the changes in legislation. There were more negative than positive comments, and negative commentary generated more replies. Positive comments were received more positively by other users while negative comments were received more negatively. The total sum of negative comments was greatly influenced by a small number of very active participants. Negative commentary focused more on broad concepts and principles related to government, power, and individual rights rather than specific issues in the Nova Scotian context. Substantial issues of trust in the government and healthcare system were evident.

Conclusions
There were strong positive and negative sentiments expressed in the comments, but the total sum of negativity in the comments was significantly influenced by a small number of commentators. Analysis on the presumed consent concerns can be helpful to inform public outreach efforts.
Prognostic impact of catheter ablation in patients with asymptomatic atrial fibrillation
Authors: Kawaji Tetsuma , Shizuta Satoshi , Tanaka Munekazu , Nishiwaki Shushi , Aizawa Takanori , Yamagami Shintaro , Komasa Akihiro , Yoshizawa Takashi , Kato Masashi , Yokomatsu Takafumi , Miki Shinji , Ono Koh , Kimura Takeshi 
Published: December 2022

Background
Catheter ablation for asymptomatic atrial fibrillation (AF) remains controversial. The aim of the present study was to explore the prognostic impact of catheter ablation in asymptomatic AF patients.

Methods
We performed a post-hoc analysis of 537 risk-matched pairs of AF patients receiving first-time catheter ablation or conservative management. The primary outcome measure was a composite of cardiovascular death, heart failure (HF) hospitalization, ischemic stroke, or major bleeding. The study patients were divided into asymptomatic and symptomatic patients, and were further divided according to the presence or absence of previous AF-related complications (ischemic stroke or HF hospitalization).

Results
Most baseline characteristics were well balanced between the catheter ablation versus conservative management groups. The median follow-up period was 5.3 years. Catheter ablation as compared to conservative management was associated with significantly lower incidence of the primary outcome measure in the asymptomatic AF patients (14.7% versus 25.4% at 8-year, log-rank P = 0.008). However, the advantage of catheter ablation was significant only in the high-risk subset of patients with the previous AF-related complications (19.2% versus 55.6% at 8-year, log-rank P = 0.006), but not in those without (13.9% and 17.3%, P = 0.08). On the other hand, among the symptomatic AF patients, catheter ablation was associated with significantly lower incidence of the primary outcome measure regardless of the previous AF-related complications.

Conclusions
In the post-hoc analysis of the matched AF cohort, catheter ablation as compared with conservative management was associated with better long-term clinical outcomes among asymptomatic AF patients only when the previous AF-related complications were present.
Cost-effectiveness of PARP inhibitors in malignancies: A systematic review
Authors: Ding Haiying , He Chaoneng , Tong Yinghui , Fang Qilu , Mi Xiufang , Chen Lingya , Xin Wenxiu , Fang Luo 
Published: December 2022

Objectives
Poly (ADP-ribose) polymerase inhibitor (PARPi) have become a mainstay for the treatment of BRCA-mutant malignancies. PARPis are likely to be more effective but also bring an increase in costs. Thus, we aimed at evaluating the cost effectiveness of PARPis in the treatment of malignancies.

Methods
Studies of cost effectiveness of PARPis were searched from PubMed, Web of Science, and Cochrane Library. Key information was extracted from the identified studies and reviewed. Quality of the included studies was evaluated using Quality of Health Economic Studies (QHES) instrument. Modeling techniques, measurement of parameters and uncertainty analysis were analyzed across studies. Interventions and cost-effectiveness results were reported stratified by patient population.

Results
Among the 25 studies identified, we included 17 on ovarian cancer, 2 on breast cancer, 3 on pancreatic cancer, and 3 on prostate cancer that involved olaparib, niraparib, rucaparib, and talazoparib. All studies had a QHES score of above 75. In the maintenance therapy of ovarian cancer, additional administration of olaparib was cost-effective for newly diagnosed patients after first-line platinum-based chemotherapy but was not cost-effective for platinum-sensitive recurrent patients in majority studies. However, the economic value of other PARPis in ovarian cancer as well as all PARPis in other tumors remained controversial. Cost-effectiveness of PARPi was primarily impacted by the costs of PARPi, survival time, health utility and discount rate. Moreover, genetic testing improved the cost-effectiveness of PARPi treatment.

Conclusions
PARPi is potentially cost-effective for patients with ovarian, pancreatic, or prostate cancer. Genetic testing can improve the cost-effectiveness of PARPi.