bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of hepatic prostaglandin E2 level in carbamazepine induced liver injury
Authors: Oba Ken-ichi , Shimada Hiroaki , Hashimoto Ryota , Kawase Atsushi , Nakanishi Takeo , Iwaki Masahiro 
Published: February 2022

Abstract

Objective. Carbamazepine (CBZ), a widely used antiepileptic drug, is one major cause of the idiosyncratic liver injury along with immune reactions. Conversely, prostaglandin E2 (PGE2) demonstrates a hepatoprotective effect by regulating immune reactions and promoting liver repair in various types of liver injury. However, the amount of hepatic PGE2 during CBZ-induced liver injury remains elusive. In this study, we aimed to evaluate the hepatic PGE2 levels during CBZ-induced liver injury using a mouse model.

Methods. Mice were orally administered with CBZ at a dose of 400 mg/kg for 4 days, and 800 mg/kg on the 5th day.

Results. Plasma alanine transaminase (ALT) level increased in some of mice 24 h after the last CBZ administration. Although median value of hepatic PGE2 amount in the CBZ-treated mice showed same extent as vehicle-treated control mice, it exhibited significant elevated level in mice with severe liver injury presented by a plasma ALT level >1000 IU/L. According to these results, mice had a plasma ALT level >1000 IU/L were defined as responders and the others as non-responders in this study. Even though, the hepatic PGE2 levels increased in responders, the hepatic expression and enzyme activity related to PGE2 production were not upregulated when compared with vehicle-treated control mice. However, the hepatic 15-hydroxyprostaglandin dehydrogenase (15-PGDH) expression and activity decreased significantly in responders when compared with control mice.

Conclusions. These results indicate that elevated hepatic PGE2 levels can be attributed to the downregulation of 15-PGDH expression under CBZ-induced liver injury.
Extra-adrenal phaeochromocytoma in a resource poor setting: A case report
Authors: Emuze Martins Ehizode , Esan Arinola , Adeleye Jokotade , Ifeh Marcus O. , Takure Augustine , Akande Temilola , Balogun William , Lawal Abimbola Olukayode 
Published: February 2022

Abstract
Phaeochromocytomas are catecholamine-secreting tumors arising in the chromaffin cells of the adrenal medulla. They are a rare cause of secondary hypertension. However, catecholamine secreting tumors may also be found in the extra-adrenal sites, producing similar symptoms as the adrenal phaeochromocytoma. The extra-adrenal phaeochromocytomas, are referred to as paragangliomas (PGLs). About 75% of extra-adrenal phaeochromocytomas are intra-abdominal, mostly located in perinephric, periaortic, and bladder regions. Most phaeochromocytomas secrete excessive amount of epinephrine and norepinephrine, whereas most paragangliomas secrete only norepinephrine. The excessive secretion of these products could lead to paroxysms of symptoms that could be life threatening. Medical management is initially offered, but definitive treatment involves surgical removal of the tumor, which requires promptness on the both the clinician and the patient sides. We present a case of an extra-adrenal phaeochromocytoma in an adult male with revealing imaging of a mass surrounding the bladder. The patient was managed with both alpha- and beta-adrenergic blockers. He declined the surgery and eventually died after appearing in an acute hypertensive crisis.
EU Legislative Support in the Waste Sector
Authors: Marišová Eleonóra , Valenćiková Marina 
Published: February 2022

Abstract
In the waste sector, EU Member States implement EU legislation. They rely on EU Directives and their waste legislation and policies. During the evaluated period (2015–2021), the Slovak Republic amended the Waste Act 79/2015 Coll. and issued strategy papers following EU legislation. France adopted its National program for prevention of waste and Finland its National waste management plan. In our research, we use a method of comparison and analysis of selected legislative documents to examine the achievement of the Green Deal’s objectives in the Slovak Republic and selected EU countries. We have shown the legislative process results through research, which indicate the achievement of set waste management goals. In our future research we will focus on building waste management infrastructure in the EU since it is necessary to apply the idea promoting the support of such waste treatment facilities that will be sustainable throughout their existence.
Quality Soil as a Pathway to Healthy Food in the EU – Project Information
Authors: Bohátová Zuzana , Palšová Lucia , Lazíková Jarmila 
Published: February 2022

Abstract
Globalization and the pressure to increased industrial agriculture result in deterioration of the environment, climate change and a serious threat to human and animal health. Soil contamination affected by the environmental pollution is one of the most pressing issues in the political and expert debate on food safety within the related EU policies as Common Agricultural Policy, EU agri-environmental, EU food policy and EU health policy.
Blessing and curse of crowdsourcing among educational experts - a study of teachers’ willingness to contribute as a crowd
Authors: Girshin Rina Zviel , Gajek Elżbieta 
Published: February 2022

Abstract
Crowdsourcing is a new technique of gathering data or performing large scale tasks by outsourcing it to a wider public. Its role and potential in language education is investigated in first in its volume research - enetCollect (European Network for the Combination of Language Learning and Crowdsourcing Techniques) COST project. This paper presents the most pertinent data about highly successful crowdsourcing portals for language learning, some educational projects based on teacher’s contributions and analysis of a survey as a crowdsourcing activity. The paper analyses two surveys: a low response rate, large scale pan-European survey wherein a sample of language teachers od all station all over Europe was asked to answer some crowdsourcing related questions (Arhar Holdt et al., 2020) and a high response rate, small scale, survey among the distributors of the first survey in which they were asked to analyse the numbers and techniques they used to reach the crowd. The focus of this article is on an extension study to the teacher survey in which thousands of teachers were approached but the response rate was relatively low. While such low response data in other cases would have been perceived as a drawback and are rarely analyzed, in the context of crowdsourcing meta research this could be a goldmine of importance. The article demonstrates how educators mayor may not be willing to participate in a crowdsourcing activity.
Time in literary translation: Anticipation of retrospection, temporality of reading and living
Authors: Fentaw Alebachew , Dagnew Tesfaye , Guadu Ayenew 
Published: February 2022

Abstract
Aiming at explicating structural prolepsis, and how temporality of reading and living are related, the study was conducted on Tell Me Your Dreams (1998) and its respective Amharic translation (Hilimishn Achawichgn-ህልምሽን አጫውችኝ, 2009).The English novel is anticipation of retrospection. The structural prolepsis propels the story without excursion. But the Amharic translation is not; there is no structural prolepsis. The present is constructed retrospectively and reveals that the best of times is yet to come in the English novel; the future has a retrospective significance of meaning to the present. There is a hermeneutic circle between the presentification of reading the English novel and the depresentification of real life present. The present of the English novel and the lived present of real life are experienced in preterite form in relation to a future to come. The future of real life and the English narrative are the same for both are unknown and imagined. The A and B philosophy of time solidified the literariness of the English narrative, but temporal becoming is emphasized in the Amharic translation. The past has just been, and so is not; the future is to be, and so is not yet. Thus, its literariness can’t be sensed.
Evidence of amorphous Ca-phosphate precipitate caused by bio mineralisation in 4-5th CE lime plasters of the previously submerged east coastal monument of Salvankuppam
Authors: Singh Manager R. , Kumar S. Vinodh , Ganaraj Kuntikana 
Published: February 2022

Abstract
The lime plasters of the excavated monument of Salvankuppam, previously submerged and exposed by the Tsunami occurred in the Indian Ocean on 26th December 2004 was studied with different analytical techniques. The temple is dated 4-5th century CE. The XRF, XRD, FTIR, NMR, SEM-EDX analysis of the lime plasters evidenced particular occurrence of phosphatised bacterial remains in saline conditions. The formation of amorphous Ca-phosphate by bio mineralization was identified in the plasters by the analyses. The plasters are made of air-lime with coarse aggregates and seashells inclusion as confirmed by the thermal and chemical analysis. The microstructure and morphological investigations of mineralized microbial structures by SEM-EDX indicated the formation of amorphous Ca-phosphate. The unordered and fibrous spherulites have hardened and reduced porosity of the plaster by bio mineralization as observed through MIP analysis. The 16S rRNA sequencing has identified the Pseudomonas strains mainly responsible for the clustering of amorphous Ca-phosphate particles around the bacterial colony.
Developing teamwork skills in a course on ore deposits
Authors: Barker Abigail K. 
Published: February 2022

Abstract
Teamwork has distinct pedagogic advantages and is also an important transferable skill and the dominant mode of work graduates encounter in the workplace. However, students rarely become proficient in teamwork skills during their education. The goal was to test strategies to improve teamwork skills in a course on Ores deposits, MSc Earth Science, Uppsala University. A focus on team-work was established by presenting the collaborative practicals as a series of linked opportunities to work together, get feedback on the teamwork process and reflect on and evaluate the teamwork. During the collaborative PBL sessions sociograms were used to provide feedback. Criteria based evaluation was also used to evaluate task oriented and interpersonal skills. Sociograms and criteria based evaluation promoted behavioural changes that improved teamwork interactions.
Acute myelogenous leukemia – current recommendations and approaches in molecular-genetic assessment
Authors: Yahya Dinnar , Hachmeriyan Mari , Micheva Ilina , Chervenkov Trifon 
Published: February 2022

Abstract
Acute myelogenous leukemia is a multi-step hematological malignancy, affecting function, growth, proliferation and cell cycle of myeloid precursors. Overall assessment of patients with the disease requires among everything else, a comprehensive investigation of the genetic basis through various methods such as cytogenetic and molecular-genetic ones. This clarification provides diagnostic refinement and carries prognostic and predictive value in respect of essential therapeutic choices.
With this review of the literature, we focus on summarizing the latest recommendations and preferred genetic methods, as well as on emphasizing on their general benefits and limitations. Since none of these methods is actually totipotent, we also aim to shed light over the often-difficult choice of appropriate genetic analyses.
Method of Improving Incomplete Spatial-Temporal Data in Inland Navigation, on the Basis of Industrial Camera Images – West Oder River Case Study
Authors: Stępień Grzegorz , Kujawski Artur , Tomczak Arkadiusz , Hałaburda Roman , Borczyk Kamil 
Published: February 2022

Abstract
Main aim of the paper is to use a single non-metric camera to support the determination of the position of. Authors propose to use the existing infrastructure of CCTV cameras mounted on bridges and wharves to determine the position of inland waterway vessels. Image from cameras giving the pixel coordinates of moving object is transformed to the geodetic data domain using a modified projective transformation method. Novel approach is to use of Sequential Projection Transformation (SPT) which additionally uses virtual reference points. The transformation coefficients calculated using the virtual points are used to determine the position of the vessels and are also simultaneously used to calibrate the industrial camera. The method has been verified under real conditions, and the results obtained are average 30% more accurate compared to the traditionally used projective transformation using a small number of real points.
A New Method to Boost VoIP Performance Over IPv6 Networks
Authors: Abualhaj Mosleh M. , Al-Khatib Sumaya N. 
Published: February 2022

Abstract
The demands on virtual communication have increased noticeably during the COVID-19 pandemic lockdown. As an essential part of virtual communication, VoIP should be promoted to achieve the desired level of performance. One critical area investigated in VoIP is the bandwidth utilization (BWU) of the VoIP over IPv6 networks. Enhancing BWU will impact call capacity and quality; it increases call capacity and boosts call quality. Unfortunately, a considerable amount of bandwidth is wasted when running VoIP over IPv6 networks. This is due to the large size of the IPv6 header and the small size of the speech frame. This paper proposes a new method to handle the inefficient BWU when running VoIP over IPv6 networks. The proposed method combines multiplexing multiple VoIP packets in one IPv6 header and using the superfluous fields to carry a portion of the speech frame. Therefore, the proposed is called packet multiplexing and carrier fields (PMCF). Investigation of the PCMF method has been done using four metrics to measure the promotion in BWU, namely calls capacity, header size, bandwidth saving, and speech frame shortening metrics. With the four metrics, the PMCF method has outperformed the comparable methods. For instance, the call capacity has been promoted by up to 269% compared to the typical IPv6 method in the tested scenarios. Therefore, the PMCF method is a feasible solution to facilitate the BWU of VoIP when running VoIP over IPv6 networks.
Efficiency of Ship Operation in Transportation of Oversized and Heavy Cargo by Optimizing the Speed Mode Considering the Impact of Weather Conditions
Authors: Onyshchenko Svitlana , Melnyk Oleksiy 
Published: February 2022

Abstract
Prior to commencing the voyage planning procedure, the entire navigation area on the forthcoming passage should be divided into several sections, depending on various factors, such as traffic density, restricted depths, availability of ship reporting systems, hydrometeorological conditions, high risk navigation areas in order to outline measures to ensure the safety of ship’s navigation. In addition, these factors have direct impact on the ship’s speed during the voyage. On the other hand, slow steaming can reduce fuel consumption on the same section of the route by 10-15%. Reducing the ship’s speed can significantly minimize its operating costs. However, when choosing economically feasible ship’s speed it should be kept in mind that reducing the speed can lead to a significant decrease in the number of voyages per year and, consequently, to the reduction of annual freight income. Therefore, a practically important and relevant problem is the necessity to find the speed of ship operation, which will provide a balance between economical fuel consumption and profits from ship operation. The classic approach to optimizing the speed mode of ships is based on the cubic dependence of fuel consumption on speed. Therefore, depending on the distance between ports, the duration of the voyage and the conditions for the time of arrival of the ship to the port, in the modern publications were proposed approaches to the optimization of the speed mode, based on the additional income or time-charter equivalent.
Competence of Bus Rapid Transit Systems Coupled with Transit Signal Priority at Signalized Junctions
Authors: Desta Robel , Tóth János 
Published: February 2022

Abstract
One of the primary causes of poor public transport performance is delays at intersections. Among the efficient and sustainable solutions to boost mass transportation performance, Bus Rapid Transit (BRT) consists of infrastructures integrating dedicated bus lanes and smart operational service with different ITS technologies like Transit Signal Priority (TSP). This research studies the competence of buses operating on junctions of the BRT corridor where they have Signal Priority on the dedicated lane. The studied intersection is located around the center of the Addis Ababa BRT-B2 line, which is relatively gentle grade and characterized by the high traffic and pedestrian volume. Microscopic models were created for the chosen intersection, along with possible calibration and validation; moreover, a statistical comparison was performed to evaluate different scenarios with the goal of displaying the deployment benefits. To assess the performance of BRT buses and their overall influence on general traffic, scenarios with and without TSP were evaluated. PTV VISSIM and the VisVAP add-on simulation program were used to examine TSP alternatives. Incorporating TSP reduced the travel time by up to 4.78% in the priority direction, the average travel speed increased by 7.25%, and the queue length also reduced by a maximum of 6%, whereas in the non-priority direction, the queue length increased by a maximum of 2.5%. Moreover, the overall average passenger delay has reduced by an average amount of 15%. One of the simplest ways to improve transit performance could be signal priority strategies, which has a minor influence on the general traffic.
Novel Modeling Approach of Carbonate Reservoirs by Integrating Geological Facies, Diagenesis, and Wireline Logs for Field Development with Insights into Low Resistivity Pay
Authors: Al-Nasser Kadhem , Alnazghah Mahmoud 
Published: February 2022

Abstract
Characterizing carbonate reservoirs is challenging due to their inherent complex nature, while diagenetic overprint causes an added layer of complexity. Diagenesis may enhance or deteriorate reservoir properties resulting in a wide range of pertinent rock types. The studied reservoirs consist of several shallowing upward cycles, which are capped by tidal flats lithofacies and evaporites, governing the spatial and temporal distribution of the reservoir units. In this work, we have used existing data to link sedimentology, stratigraphy, diagenesis, and wireline logs to build a full-field characterization model for improved well performance and prediction.
The state-of-the-art characterization workflow includes data from sedimentologic core characterization, petrographic and diagenetic analyses, routine core analysis (RCA) at multiple overburdens, mercury injection capillary pressure (MICP) measurements, and well wireline logs. The process starts with basic facies description for all cored wells, establishing the stratigraphic framework, and then characterizing the impact of the diagenetic overprint on depositional lithofacies. Using wireline logs, the altered depositional lithofacies by diagenesis are distributed within each mapped cycle of the established stratigraphic framework and then are used to generate/predict petrophysical rock types. The final detailed and obtained reservoir property information for all the facies is used in the 3D reservoir model.
This work shows and explains how facies and diagenesis led to the development of low resistivity pay positively affecting a specific reservoir. This low resistivity interval, which is not common in carbonate, is related to the presence of abundant paramagnetic minerals in the reservoir. The dispersed conductive minerals have more effect on resistivity behavior as they will induce conductivity due to their distribution and mixing with irreducible water. Variation of depositional facies has a major influence on the flow geometry. We considered these variations while generating permeability modeling as well as averaging methods, which had been used later in both static and dynamic modeling. Therefore, our petrophysical rock typing and permeability and saturation height modeling were linked to both depositional and diagenetic processes.
Establishing the lithofacies relationship to flow geometry will improve the static to dynamic match, in-fill drilling plan, as well as the well design (vertical/slanted/horizontal) for both producers and injectors.
Joint Inversion of Seismic and DC Geophysical Data Using Local and Global Optimization Algorithms
Authors: Edigbue Paul , Demirci Ismail , Hamdan Hamdan , Al-Shuhail Abdullatif , Akca Irfan , Soupios Pantelis , Candansayar Emin 
Published: February 2022

Abstract
Geophysical inversion is usually carried out to quantitatively analyze the earth model and estimate its physical properties. Successful delineation of these properties such as layer boundaries, or other near-surface structures are crucial to understand the near-surface inhomogeneity. In this study, we focus on the use of joint inversion of seismic refraction and geoelectrical resistivity datasets using local and global optimization methods. The idea is to integrate the two optimization techniques to minimize the challenges faced by each algorithm when applied alone. This hybrid algorithm (local and global) is applied on synthetic data representing simple resistivity and velocity models. About 70% of the anomalies in both seismic and DC resistivity methods were reconstructed in terms of amplitude and geometry using the local optimization algorithm, while the global optimization algorithm shows improved results as it reconstructed about 80% of the amplitude and geometry of the anomalies in both geophysical methods. The result of the synthetic application shows that the hybrid algorithm provides promising outputs in terms of resolution, geometry and amplitude of the anomalies, and computation run time.
Integrated Seismic Processing and Geological Identification of the Late Eocene Reservoir Body in Lufeng Block, Pear River Mouth Basin
Authors: Li Li , Ma Fujian , Xu Chao , Liu Lianlian , Wang Yaosen , Zeng Rui , Gong Zijing , Liang Donghai , Roy Dipanka , Ahmed Ramy , Saumya Sachit 
Published: February 2022

Abstract
The main exploration challenges of the Lufeng Sag, Pear River Mouth Basin (PRMB) area are complex fluvial-deltaic depositional stacking and associated oil-water distributions. The reservoir bodies are buried at approximately 2700 to 3000 m under mud lines, and at these depths the quality of the seismic data is too poor to accurately characterize the reservoirs. The poor seismic quality also results from complex fluvial sedimentation that is overlain by a high-speed limestone layer, as well as deeply buried, thin intervals of interest.
In this paper we propose an integrated approach to reprocess the data, increase the imaging quality, and improve the geological understanding of the area. The geology-guided seismic data processing and integrated interpretations, along with seismic inversions, are proved to be a practical solution to improve geologic understanding and help to conduct a drilling campaign for infill wells. The new processed data show improved image quality, including the signal-to-noise ratio and the resolution via noise attenuations, demultiples, and broadband extension processing.
Two sedimentation sources are identified with the new data, while the legacy data were vague, and the reservoir layers were interpreted as a single-sourced fluvial-deltaic depositional system. These misleading interpretations do not help us understand the complex oil-water relationship discovered by drilling and failed to locate the sweet spots for future infill wells. However, the new processed data shed light on all the issues and have become a game changer for the area.