bluuebunny/crossref_metadata_2025_split huggingface dataset:
DSMC Study of Strong Shear Nonequilibrium Phenomenon in Hypersonic Knudsen-Layer Flows
Authors: Liu Wenbin , Zhang Jinbai , Lee Chun-Hian 
Published: June 2022

Abstract
A series of plane Couette flows of rarefied argon gas under different flowfield settings are simulated by the direct simulation Monte Carlo method. The relaxation process of strong shear nonequilibrium is systematically studied. The results show a qualitatively platform-shaped distribution of molecular streamwise velocity under the conditions of small wall spacing (roughly in the Knudsen layer), and large shear rate and wall speed. The analysis of this phenomenon will help understand the relaxation process of hypersonic Knudsen-layer flow and provide some references for future modelling research.
Structural damage detection based on data fusion method
Authors: Wu Zhe , Xia Wei , Zhang Yuteng 
Published: June 2022

Abstract
In order to improve the accuracy of structural damage detection, data fusion technology is applied to structural damage detection. Three damage identification algorithms based on vibration are used to analyze the damage state. Then, the improved D-S combination method was used to combine the obtained diagnosis results to obtain the final diagnosis results. The results show that this method can effectively improve the accuracy of structural damage detection and has a good application prospect in engineering.
Dynamics simulation of rolling bearing system with pedestal looseness in speed-up train
Authors: Yang Juping , Wang Junguo , Zhao Yongxiang 
Published: June 2022

Abstract
The paper mainly studies the dynamics characteristics of the roller bearing system with pedestal looseness in speed-up train. Considering eccentricity, damping coefficient, stiffness of shaft, and support forces of roller bearing, a centralized mass model of roller bearing system of speed-up train is presented. Moreover, numerical analysis method is adopted to solve the dynamics responses. Based on the trajectory cures, phase plane portraits, Poincaré maps, and amplitude spectrum cures, the dynamics characteristics are analysed when the motor rotating speed and gap of the looseness are changed. The simulation results reveal some complex dynamic behaviour such as periodic motion, quasi-periodic motion, multi-periodic motion and chaotic motion. These results will help us understand and harness these dynamics behaviour of the proposed bearing system of speed-up train.
Finite Element Model Updating Approach for Structural Health Monitoring of Lightweight Structures Using Response Surface Optimization
Authors: Eidukynas D , Adumitroaie A , Griškevičius P , Grigaliunas V , Vaitkūnas T 
Published: June 2022

Abstract
Mechanical defects in the structure changes it’s vibration response. There is a wide variety of methods that examine changes in measured vibration response to detect, locate, and characterize damage in structural and mechanical systems. One method to evaluate the structural changes and to analyse their causes is the Finite Element Model Updating (FEMU). The objective of this research is to investigate the FEMU procedure for mechanical damage identification and to propose an experimental-computational SHM method for lightweight structures. The structural dynamic response to impact excitation of a structure with and without defects are collected from transient and modal analysis using Ansys FE software. Afterwards, FEMU algorithm using Ansys Surface Response Optimization is investigated for its applicability to damage identification. Obtained results revealed the possibility to use this algorithm with having minimum discrepancy between parameters obtained from experiments and finite element modelling.
Evaluation of oxygen consumption at biologically active surfaces using scanning electrochemical microscopy
Authors: Zinovicius A , Rozene J , Dirma G , Striska L , Stankaitis S , Morkvenaite-Vilkonciene I 
Published: June 2022

Abstract
Scanning electrochemical microscopy (SECM) is a local electrochemical analysis technique, which performs scanning of the sample by ultramicroelectrode (UME) [1]. The result of measurement usually is current, which depends on the electrochemical properties of the surface of interest. The errors can be observed if UME geometry is not ideal [2,3]. This happens after UME polishing or breaking after contact with the sample surface. And the aim of this research was to evaluate oxygen consumption at biologically active surfaces using scanning electrochemical microscopy. That is why the oxygen consumption at the surface of interest with UME of different geometry was evaluated in this work. The model results were compared with experimental data. The computational experiment was performed with the SECM model using diffusion equations in the COMSOL program. This model could be further improved to measure diffusion rates with different probe geometries and coefficients.
Small size 2-DOF piezoelectric platform for unlimited locomotion
Authors: Čeponis A , Mažeika D , Jūrėnas V , Vasiljev P , Bareikis R , Borodinas S , Ostaševičius V 
Published: June 2022

Abstract
The paper represents a numerical and experimental investigation of a 2-DOF piezoelectric positioning platform that can provide unlimited locomotion in the plane. The platform's operation principle is based on the excitation of the first bending mode of piezoelectric bimorph plates. A numerical investigation of the 2-DOF platform was performed, and it was found out that the suitable vibration mode of the bimorph plates occurs at 23.54 kHz Harmonic response analysis showed that the maximum displacement amplitude of the contact reached 561.12 μm or 2.67 μm/Vp-p while an excitation signal of 210 Vp-p was applied. The experimental study was performed and showed that maximum linear velocity of 44.45 mm/s or 0.212 mm/s/Vp-p were obtained while the load of 55.68g and applied and electrical signal of 210 Vp-p was used. In addition, at the same conditions output force of the platform was measured, and it was found that the platform is able to provide 44.16 mN of output force.
Mathematical modelling and theoretical research of micropositioning system
Authors: Subačiūtė - Žemaitienė Jurga , Trečiokaitė Vaiva , Šešok Nikolaj , Šutinys Ernestas , Dzedzickis Andrius , Tamošiūnas Justas , Masalskyi Viktor , Bučinskas Vytautas 
Published: June 2022

Abstract
In this paper, modelling and theoretical research of micropositioning system with stepper motor are proposed. The aim of our research is to provide a method, which is suitable for modelling a ball-screw based positioning system controlled by a stepper motor. A created dynamical model of micropositioning system mechanical parts. The second type of Lagrange equation is used to construct the mathematical model. For modelling micropositioning systems, Matlab/SIMULINK software is used. MatLab is used to perform calculations of some equations, and SIMULINK is used to create a dynamic model of a micropositioning system and simulate system operation. Analysis of motion smoothness showed that even for systems with relatively small screw radius and pitch 1/4 microstepping mode are unable to provide smooth movement. The smoother the movement, the less energy is required to overcome friction.
An optimisation problem for exoskeleton-aided functional rehabilitation of an upper extremity
Authors: Falkowski P 
Published: June 2022

Abstract
With pandemics, a problem of non-guaranteed constant access to rehabilitation aroused. As civilisation diseases attack a significant share of the population, providing motor treatment seems to be one of the biggest challenges towards the healthcare system of the future. While taking into account the severe level of disabilities and unexpected circumstances, the trainings may require being held in a house of a patient. Moreover, due to emergencies, a physiotherapist may not be able to participate in it personally. Thus, to mitigate the repercussions of such situations, advanced mechatronic systems for remote-home-rehabilitation have to be developed. Moreover, surveyed physiotherapists, claim that function-oriented training, robot aid, remote treatment and home therapy are the leading trends for rehabilitation of the future. Combining these is relatively difficult, as automated robotic rehabilitation requires an advanced control system. As to partially support motion along the pre-programmed trails, an optimisation problem needs to be solved. Not only to follow the trail transitionally but also to control a tilt of a gripped object and to avoid immediate large changes of velocities and accelerations if not necessary. This paper presents an approach towards an optimisation problem based on an exoskeleton of three driven and two free degrees of freedom. Simulated function-oriented training consists of diverse typical motions, such as drinking, eating, writing, steering a control wheel, lifting a bag from the ground, and lifting an object onto a shelf. Based on these, an optimisation problem is formulated. Works presented in the paper are an integral part of a planned long-term research on a home-remote-rehabilitation with a use of an exoskeleton.
Quality Research of Edge Banding of Unit Furniture
Authors: Miškinytė Ugnė , Juknelevičius Romualdas 
Published: June 2022

Abstract
Edge banding is used to cover cut sides of wood materials such as plywood or particleboard. The quality of two different furniture edge banding materials and their thickness were studied in this paper. The research was focused on most widely used in the Lithuanian furniture industry acrylonitrile butadiene styrene (ABS) and oak veneer. The experiments were performed to investigate the mechanical properties of materials and SolidWorks Simulation were made as well. The conclusions and recommendations can ensure the improvement and optimization of the processes of furniture industry. Structure of the paper: introduction, review of literature, methodology of experiment, results of research and their consideration, conclusions, references.
5DOF planar – rotary motion piezoelectric robot
Authors: Čeponis A , Jūrėnas V , Mažeika D 
Published: June 2022

Abstract
A novel resonant type five degrees of freedom (5DOF) mobile piezoelectric robot is proposed and analysed. The piezoelectric robot performs unlimited linear working motion in the plane and rotates the positioning table or sphere about three axes independently. The piezorobot can be used for precise positioning or transportation of small objects and make complicated locomotion trajectories. The piezoelectric robot is designed as a compound structure and includes a piezoelectric ring and a special ring-shaped bronze layer. Electrodes of the piezoelectric ring are divided into six equal sections. Excitation of the piezoelectric robot is performed by using a single switched harmonic signal applied to the particular electrode. The operation principle of the piezoelectric robot is based on the excitation of the third radial vibration mode of the piezoelectric ring. The numerical and experimental study was performed, and the operating principle was validated. The maximum linear velocity of 18.8 mm/s and rotational speed of 31.3 rpm were achieved when load of 25.1g and excitation voltage of 200 Vp-p were applied.
Manganese oxide nanoparticles inhibit selectively the in vitro and in vivo growth of human colorectal SW620 adenocarcinoma cells
Authors: Razumov Ivan Alekseevich , Troitskii Sergei Yurievich , Solovieva Olga Igorevna , Boldyrev Nikita Dmitrievich , Zavjalov Evgenii Leonidovich 
Published: June 2022

Abstract
A promising area of oncotherapy is the use of nanomaterials for diagnostics and imaging, as well as for delivering drugs and direct effect agents to tumour cells. We used earlier manganese oxide nanoparticles (NP MnO) as magnetic resonance imaging agents for visualisation and suppression of in vitro and in vivo growth of human glioblastoma cells. The present study was to demonstrate the selective antitumor effect of NP MnO against human tumour cells of different tissue origins, in particular, cells SW620, human colorectal adenocarcinoma. It was shown that NP MnO can inhibit selectively in vitro growth of SW620 cells; the index of selective cytotoxicity against human colorectal adenocarcinoma cells was 20. The range of optimal NP MnO doses was determined using subcutaneous introduction of the nanoparticles to SCID mice; the doses no more than 0.96 mgMn kg−1 had practically no local toxic effect in the animals. The subcutaneous administration of NP MnO in the specified dose range inhibited the growth of SW620 xenografts in SCID mice and led to an increase in their life expectancy. With administered NP MnO in doses of 0.32 and 0.96 mgMn kg−1, the index of inhibition of tumour growth for 21 days from the beginning of the introduction of nanoparticles was 43.0% and 69.8%, respectively. NP MnO seem promising for developing nanotheranostics agents for the visualisation and treatment of human tumours of different tissue origins.
Design and fatigue analysis of diagonally reinforced structures with a negative Poisson’s ratio lattice material
Authors: Cai Liuxi , Hou Yanfang , He Yao , Li Yun 
Published: June 2022

Abstract
In this paper, a typical negative Poisson’s ratio lattice structure was studied and several diagonally reinforced 3D lattice structures were designed and analysed using the finite element method. On this basis, the fatigue life of the unreinforced and reinforced structures was calculated using SIMULIA Fe-safe software. Meanwhile, the fatigue failure process of the lattice structure was systematically simulated and quantitatively analysed by combining the multiaxial fatigue damage model. Results show that the enhancement design from the cell structure can provide an anti-diagonal shear enhancement effect. The structure A, B, and C can decrease the maximum von Mises stress by 95.8, 97.1, and 94.66%, and increase the compressibility by 80%, 56%, and 127%, respectively. The structure A enhancement yields the best overall performance in terms of structural stress, compressibility, and negative Poisson’s ratio properties enhancement. Compared with the unreinforced structure, the lifetime distribution of the structure A reinforced structure changes in both position and level. The overall lifetime has been improved from 102.813 of the unreinforced structure to 107 of the reinforced structure. Quantitative calculation of the fatigue damage is consistent with the fatigue life prediction results, which further validate the effectiveness of the diagonal enhancement method and the enhancement structure of the negative Poisson’s ratio lattice structure.
Structure modification of nonsteroidal brassinolide-like compound, NSBR1
Authors: Takimoto Seisuke , Nishikawa Bunta , Matsuo Midori , Hinata Shiori , Hisatomi Taiki , Yamagami Ayumi , Nakano Takeshi , Nakagawa Yoshiaki , Miyagawa Hisashi 
Published: June 2022

ABSTRACT
Brassinolide (BL) is a possible plant growth regulator in agriculture, but the presence of a steroid skeleton hampers the field application of BL in agriculture because of its high synthetic cost. We discovered NSBR1 as the first nonsteroidal BL-like compound using in silico technology. Searching for more potent BL-like compounds, we modified the structure of NSBR1 with respect to 2 benzene rings and the piperazine ring. The activity of synthesized compounds was measured in Arabidopsis hypocotyl elongation. The propyl group of butyryl moiety of NSBR1 was changed to various alkyl groups, such as straight, branched, and cyclic alkyl chains. Another substituent, F, at the ortho position of the B ring toward the piperazine ring was changed to other substituents. A methyl group was introduced to the piperazine ring. Most of the newly synthesized compounds with the 3,4-(OH)2 group at the A ring significantly elongated the hypocotyl of Arabidopsis.
Molecular Analysis With 16S rRNA PCR/Sanger Sequencing and Molecular Antibiogram Performed on DNA Extracted From Valve Improve Diagnosis and Targeted Therapy of Infective Endocarditis: A Prospective Study
Authors: Mularoni Alessandra , Mikulska Malgorzata , Barbera Floriana , Graziano Elena , Medaglia Alice Annalisa , Di Carlo Daniele , Monaco Francesco , Bellavia Diego , Cascio Antonio , Raffa Giuseppe , Sciacca Sergio , Luca Angelo , Pilato Michele , Conaldi Pier Giulio 
Published: June 2022

Abstract

Background
Molecular analysis (MA) on heart valve (HV) improves the microbiologic diagnosis of infectious endocarditis (IE). The main drawback of MA is the lack of antimicrobial susceptibility information.

Methods
We conducted a prospective cohort observational study of consecutive adult patients from April 2012 to May 2021 who underwent valve surgery at our hospital. The performance of MA, blood cultures (BC) and valve cultures (VC), and the diagnostic and therapeutic impact of MA were evaluated. Molecular antibiogram results were compared to culture-based antimicrobial susceptibility testing (AST).

Results
A total of 137 patients with definite IE and 52 patients with no IE were enrolled in the study. Among IE cases BC, VC, and MA were positive in 75 (55%), 30 (22%), and 120 (88%) of IE cases, respectively. Among 62 cases of BC-negative IE (BCNE), 57 achieved diagnosis with MA. MA led to a change of antimicrobial therapy in 92% of BCNE. MA was negative in 100% of patients with no IE. Molecular antibiogram performed on 17 valve specimens that resulted positive for pathogens potential carrier of genes encoding for multidrug resistant mechanisms showed 100% concordance with AST.

Conclusions
MA showed a high specificity and sensitivity in etiological diagnosis of IE. Molecular antibiogram could overcome the major limitation of MA that is the lack of susceptibility testing. We advocate for the inclusion of MA among diagnostic criteria for IE and for a more extensive use of molecular antibiogram when the culture result is negative, and MA is the only positive test.
The Effect of Menopausal Status, Age, and Human Immunodeficiency Virus (HIV) on Non-AIDS Comorbidity Burden Among US Women
Authors: Collins Lauren F , Mehta C Christina , Palella Frank J , Fatade Yetunde , Naggie Susanna , Golub Elizabeth T , Anastos Kathryn , French Audrey L , Kassaye Seble , Taylor Tonya N , Fischl Margaret A , Adimora Adaora A , Kempf Mirjam-Colette , Tien Phyllis C , Sheth Anandi N , Ofotokun Ighovwerha 
Published: June 2022

Abstract
Menopause may impact the earlier onset of aging-related comorbidities among women with versus without human immunodeficiency virus (HIV). We found that menopausal status, age, and HIV were independently associated with higher comorbidity burden, and that HIV impacted burden most in the pre-/perimenopausal phases.
Association of Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seroprevalence and State-Issued Nonpharmaceutical Interventions: United States, 1 August 2020 to 30 March 2021
Authors: Miller Maureen J , Himschoot Austin , Fitch Natalie , Jawalkar Sucheta , Freeman Dane , Hilton Charity , Berney Kevin , Guy Gery P , Benoit Tina J , Clarke Kristie E N , Busch Michael P , Opsomer Jean D , Stramer Susan L , Hall Aron J , Gundlapalli Adi V , MacNeil Adam , McCord Russell , Sunshine Gregory , Howard-Williams Mara , Dunphy Christopher , Jones Jefferson M 
Published: June 2022

Abstract

Background
We assess if state-issued nonpharmaceutical interventions (NPIs) are associated with reduced rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as measured through anti-nucleocapsid (anti-N) seroprevalence, a proxy for cumulative prior infection that distinguishes seropositivity from vaccination.

Methods
Monthly anti-N seroprevalence during 1 August 2020 to 30 March 2021 was estimated using a nationwide blood donor serosurvey. Using multivariable logistic regression models, we measured the association of seropositivity and state-issued, county-specific NPIs for mask mandates, gathering bans, and bar closures.

Results
Compared with individuals living in a county with all three NPIs in place, the odds of having anti-N antibodies were 2.2 (95% confidence interval [CI]: 2.0–2.3) times higher for people living in a county that did not have any of the 3 NPIs, 1.6 (95% CI: 1.5–1.7) times higher for people living in a county that only had a mask mandate and gathering ban policy, and 1.4 (95% CI: 1.3–1.5) times higher for people living in a county that had only a mask mandate.

Conclusions
Consistent with studies assessing NPIs relative to COVID-19 incidence and mortality, the presence of NPIs were associated with lower SARS-CoV-2 seroprevalence indicating lower rates of cumulative infections. Multiple NPIs are likely more effective than single NPIs.
Sacubitril/valsartan in an experimental model of heart failure with preserved ejection fraction
Authors: De Angelis A , Cappetta D , Telesca M , Bellocchio G , Urbanek K , Berrino L 
Published: June 2022

Abstract

Funding Acknowledgements
Type of funding sources: Public Institution(s). Main funding source(s): Ministry for Education, University and Research

Introduction
The majority of elderly patients with heart failure has a preserved ejection fraction (HFpEF) that constitutes a syndrome characterized by frequent hospitalizations and high mortality. Despite the growing social burden of HFpEF, the comprehension of its pathophysiology is incomplete, and treatment remains largely undefined. Aging itself may contribute independently to deterioration of diastolic function.

Methods
18-month old female Fischer 344 rats were treated with oral administration of either sacubitril/valsartan (60 mg/kg/die, 1:1 ratio) or valsartan alone (30 mg/kg/die) for 12 weeks. Tail-cuff method was used to monitor blood pressure weekly. Echocardiography and left ventricle catheterization were employed to assess systolic and diastolic function, at baseline, and before sacrifice. Cardiac tissue was used for molecular biology and histochemistry assays.

Results
Tail-cuff analysis indicated a comparable decrease in blood pressure between treatments. Hypertrophy also showed a significant reduction with both treatments. On the contrary, myocardial function analysis demonstrated that no treatment was efficacy on diastolic dysfunction. The lack of improvement of cardiac function could be attributed to the inability of the treatments to counteract the accumulation of fibrotic tissue in the left ventricle, which, in turn, is attributable to the failure to reduce the inflammatory process and oxidative stress, and to the inability to modulate angiotensin II pathway.

Conclusion
Our results evidenced that both sacubitril/valsartan or valsartan treatment was able to improve diastolic function and pro-fibrotic remodeling, partly due to a lack of effect on classical and non-classical pathways of angiotensin II.