bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL36G genetic variant is independently associated with susceptibility, severity and joint involvement in psoriasis
Authors: Moreira Cássio Rafael , Alcântara Camila Cataldi , Flauzino Tamires , Martin Ligia Marcia Mario , Lozovoy Marcell Alysson Batisti , Reiche Edna Maria Vissoci , Simão Andrea Name Colado 
Published: April 2022

Abstract

Objective/Design: A case-control study aims to evaluate the frequency of the IL36G C>T (rs13392494) and the IL36G A>G (rs7584409) variants and their association with susceptibility, joint involvement and severity of psoriasis (PsO). Subjects and Methods: The study included 154 patients with PsO and 154 controls from Brazilian population. The IL36G (rs13392494 and rs7584409) variants were genotyped by allelic discrimination assay using the real-time polymerase chain reaction. The severity of PsO was assessed using the Psoriasis Area and Severity Index (PASI). Results: Plaque PsO, PsA, and PASI > 10 were observed among 95.8%, 16.1%, and 27.9% of patients, respectively. The IL36G rs7584409 variant showed a protective effect in PsO whereas the IL36G rs13392494 variant was not associated with susceptibility to PsO. The G allele of the IL36G rs7584409 in heterozygosis and homozygosis (dominant model) was positively associated with PASI >10 and the GG genotype of this variant was associated with the presence of PsA. Conclusion: The presence of the G allele of the IL36G rs7584409 variant was associated with protection to PsO, higher PASI and the presence of PsA than the A allele suggesting that this variant may be used as a potential genetic biomarker to predict severity and joint involvement of the PsO.
The Relationship Among Adolescents’ Self-esteem, Emotional Intelligence and Friendship Quality
Authors: Ye WEI 
Published: April 2022

Abstract
Background: The purpose of this study is to analyze the relationship among self-esteem, emotional intelligence and friendship quality of adolescents. Methods: A total of 333 adolescents were investigated with the help of a questionnaire and the qualitative data of interviews were used to demonstrate the results. The data were analyzed by exploratory analysis and typical correlation analysis. Results: Self-esteem can explain 21.3% of the variance of friendship quality. All levels of self-esteem are positively correlated with company help, intimate communication, positive value, trust and respect in friendship quality, but negatively correlated with conflict and betrayal in friendship quality. Emotional intelligence can explain 36.4% of the variance of friendship quality, and all levels of emotional intelligence are positively related to the level of companionship, intimate communication, positive value, trust and respect in friendship quality, but negatively related to the level of conflict and betrayal in friendship quality. Conclusion: There is a typical relationship among self-esteem, emotional intelligence and friendship quality, and interpersonal self-esteem, trust and respect, companionship and help, and intimate communication are the main explanatory factors. Emotional adjustment, cognitive reappraisal, emotional control and company help, trust and respect, positive value, intimate communication are the main explanatory factors.
Design of a radio sensing device for open farmland environmental data collection
Authors: Lai Chien-Hung , Lai Kuan-Ting , Hwang Yuh-Shyan 
Published: April 2022

Abstract
This paper introduces a radio sensing device that is easy to manufacture and maintain, easy to install and relocate, can store solar energy, resistant to typhoon and heavy rains, and has low power consumption. With the radio sensing devices constantly collecting information on environmental changes and sending data back to the backend system designated by the customer, our system can assist the farmers predicting the production period of crops in the area, which allow farmers to plan the different field operations. In this paper, we propose an unified sensor framework and compare our design with various hardware, software and mechanism of sensing devices in the literature. The height of our device is 275mm, the bottom circle radius is 63.3mm, the weight is less than 2kg, the minimum power consumption during radio transmission is only 0.58W, and the end point transmission distance can reach 16 kilometers. Our devices are highly integrated and low power, and have been commercialized and sold worldwide.
Mechanistic modeling-guided optimization of microneedle-based skin patch for rapid transdermal delivery of naloxone for opioid overdose treatment
Authors: Puri Ashana , Tijani Akeemat , Dogra Prashant , Peláez Maria , Wang Zhihui , Cristini Vittorio 
Published: April 2022

Abstract
Naloxone, an FDA approved opioid inhibitor, used to reverse opioid overdose complications has up till date faced challenges associated with its delivery. Limitations include the use of invasive delivery forms and the need for frequent redosing due to its short half-life. Further, the use of the non-invasive commercially available intranasal form is faced with limitations such as nasal epistaxis and inability to use the intranasal channel due to nasal trauma common in addicts from frequent drug snorting. The goal of the current study was to design a rapidly dissolving polymeric microneedle (MN) patch with delivery and pharmacokinetic properties comparable to that seen with the commercially available NAL products, eliminating their highlighted limitations. Factors such as drug loading and polymer strength influenced the fabrication of the MNs. Compared to passive permeation, a reduced lag time of about 5-15 min was observed with a significant drug flux of 15.09 ± 7.68 g/cm 2 /h seen in the first 1 h (p<0.05) with an array of 100 needles (500 µm long). Increasing the MN length and density (no. of needles/unit area) made a significant difference in the amount permeated and flux (p<0.05), with latter being more influential. Further, through a mechanistic model of drug release from the patch, integrated with pharmacokinetic modeling, we optimized the design of the patch to reproduce in-silico the clinical pharmacokinetics of NAL obtained through commercial intramuscular and intranasal devices. Model simulations and analyses revealed the significance of needle base diameter and needle count in improving systemic pharmacokinetics of NAL.
Occurrence of Polycyclic aromatic hydrocarbons (PAHs) in mullet (Liza aurata) from Bizerte and Ghar El Melh Lagoons (Tunisia) and associated human health risk assessment
Authors: Ameur Walid Ben , Annabi Ali , Mhadhbi Takoua , Hassine Sihem Ben , Safouen Ghanmi , Megdihe Yassine El , Khadija Maaned , Ennaceur Soukaina , Hammami Bechir , Touil Soufiane , Driss Mohamed Ridha 
Published: April 2022

Abstract
There is a scarcity of information on the presence of polycyclic aromatic hydrocarbons in biota from Tunisian coastal ecosystems. To our knowledge, this is the first work to report these chemicals in the biota of Ghar El Melh Lagoon. In Liza aurata muscle from the Bizerte and Ghar El Melh Lagoons (Tunisia), levels of 15 priority polycyclic aromatic hydrocarbons were measured. Total PAH levels in mullet from the Bizerte and Ghar El Melh Lagoons were comparable to or lower than those found in other fish specimens from around the globe. The nature of the detected chemicals reveals petrogenic and pyrolytic anthropogenic contamination in both studied lagoons. The human health threat caused by mullet consumption was assessed, and it was observed that PAH intakes pose no threat to the local population's health.
NILS: An Artificial Neural Network Tool for Personalized Noninvasive Lymph Node Staging in Breast Cancer
Authors: Dihge Looket , Bendahl Pär-Ola , Skarping Ida , Hjärtström Malin , Ohlsson Mattias , Ryden Lisa 
Published: April 2022

Abstract
While breast cancer commonly presents at an early stage without axillary lymphatic spread, surgical axillary staging by sentinel lymph node biopsy (SLNB) is routinely performed in all patients with clinically node-negative disease. This study presents the development and implementation of a personalized prediction tool for noninvasive lymph node staging (NILS) using artificial neural network algorithms. Routinely available clinical and tumor-related variables in the preoperative setting from a consecutive cohort of 800 breast cancer cases were included in model training and internal validation. The model was trained to handle missing data for the ten input variables, and the performance to distinguish benign/metastatic lymph nodes ranged from AUCs 0.72 to 0.74, with good calibration. The potential to abstain from axillary surgery was observed in 26% of patients using NILS for the prediction of nodal status and acknowledged a false negative rate of 10%, which is clinically accepted for the standard SLNB technique.
Music festival drug checking: Evaluation of an Australian pilot program
Authors: Olsen Anna , Wong Gabriel , McDonald David 
Published: April 2022

Abstract
Background: This paper explores the feasibility of delivering a music festival based drug checking service in Australia, evaluating service design and stakeholder acceptability. Methods: Questionnaire and interview data were collected from adult service users and key stakeholders. A mixed methods approach was used to analyse the data on implementation, impact and acceptability. Results: The trial service tested 170 substances with more than 230 patrons. Adult service users had an average age of 21 years. Among adult patrons who participated in the pre- and post-drug checking questionnaires, 88 per cent of the test results were the drug expected. Evaluation results show that the experience of testing and the accompanying harm reduction brief interventions positively impacted on patrons' self-reported drug harm reduction knowledge, trust of health providers and stated drug use intentions. The service was received positively by service users.Conclusion: This is the first independent evaluation of a pilot drug checking service in Australia. Consideration of operational feasibility and self-reported behavioural change suggests that the program was successful, although communication about the interpretation of drug checking results could be improved. Future studies should develop strategies for follow-up and consider the applicability of behavioural change theory.
Relationship Between Screen Time and Body Mass Index in Young Adults
Authors: Rafique Nazish , Alkaltham Gaeda Khaled I , Almulhim Latifah Abdullah A , Al-Asoom Lubna Ibrahim , AlSunni Ahmed A , AlSheikh Mona , Ghamdi Kholoud S. Al , Yar Talay , Alabdulhadi Aseel Salah , Nadeem Farhat 
Published: April 2022

Abstract
Background: This study aimed to find the association between screen time (ST) and body mass index in young adults.Methods: This was a cross sectional study conducted on 1876 students (aged 18-22yrs) from multiple Colleges of Imam Abdulrahman Bin Faisal University, from January 2021 till June 2021. The main tools of the study were: 1) Body mass index (BMI) and an online questionnaire. The subjects were categorized into 3 main groups based on their ST: 1) Low ST< 2Hours/day, 2) Medium ST= 3 to 5Hours/day, 3) Excessive ST > 6Hours /day. Based on BMI, subjects were categorized into three main groups: Normal and underweight (BMI ≤24.9), over weight (BMI >25-29.9) and obese (BMI > 30).Results: The mean age (±SD) of participants was 20 ± 2.8 years. Average BMI was 23.5 kg/m2 . The % of students falling into the categories of normal weight, overweight and obesity was 69.2, 19.05 and 11.7% respectively . Average screen time in study participants was 8.2 ± 3.45 hrs /24 hours. 71.15% participants indicated a ST of ≥ 6 hrs/24 hours and 23.71% reported ST of 3 - 5 hrs/24 hours. Only 3.15 % of students reported ST of ≤ 2 hrs/24 hours. Although a rise in the mean BMI was observed with an increase in the ST, but this difference was not statistically significant (P=0.156). Pair wise comparison also failed to demonstrate any difference in BMI between different categorize of ST. Furthermore no significant positive correlation was found between increased BMI and excessive ST (P=0.37).Conclusion: A high percentage of young adults (31.2%) were overweight or obese, but excessive ST was not significantly associated with increased BMI in this study population. Further studies are recommended to identify the effects of other factors in causing increased BMI in young adults.
The resting-state topological organization damage of language-related brain regions in post-stroke cognitive impairment
Authors: Wang Sirui , Rao Bo , Miao Guofu , Zhang Xin , Zheng Jun , Lin Junbin , Yu Minhua , Zhou Xiaoli , Xu Haibo , Liao Weijing 
Published: April 2022

Abstract
Background: The topology of brain networks is the foundation of cognition. We hypothesized that stroke damaged topological organization resulting in cognitive impairment. The aim was to explore the damage pattern of the resting-state topology in post-stroke cognitive impairment (PSCI) patients.Methods: Thirty-seven patients with PSCI and thirty-seven gender- and age-matched healthy controls (HC) were recruited. The structural and functional data were collected from all subjects. The degree centrality (DC), betweenness centrality (BC), and global properties of brain networks were analyzed between groups. Spearman correlation analysis was performed between topological properties that changed significantly and clinical cognitive function scale scores.Results: Compared with HC, the PSCI patients had significantly reduced DC in language-related brain regions and significantly higher DC in the right frontal lobe, hippocampus, and paracentral lobule. The decreased BC was located in the left caudate, thalamus, temporal and frontal lobes. The increased BC was detected in the left cuneus and right precuneus. In addition, PSCI exhibited increased characteristic path length and decreased small-worldness. DC and BC in the left superior temporal gyrus were positively correlated with scale scores.Conclusions: PSCI patients had impaired functional topology of the language-related brain regions, mainly in the left hemisphere. The enhanced processing and relaying information of some right high-order cognitive brain regions may be a compensatory mechanism. However, the whole brain's function integration was reduced, and there was an imbalance between efficiency and consumption. The decreased DC and BC of the left superior temporal gyrus may be the biomarker of overall cognitive function.
A case of dyskeratosis congenita with prominent splenomegaly, portal hypertension, and hypoxemia
Authors: Liu Li-Juan , Niu Qiong , Cheng Xian-yong , Gao Yu , Liu Cheng-xia 
Published: April 2022

Abstract
Background: Dyskeratosis congenita is a rare hereditary disease. A correct diagnosis of this disease might be delayed due to its rarity. Therefore, a deep understanding of the characteristics of this condition is necessary to assist in early diagnosis.Case presentation: A 16-year-old male was admitted to the hospital with the complaint of abdominal pain. The patient was examined to consider the diagnosis of acute portal vein thrombosis. In the previously-consulted hospital, the patient was diagnosed with "splenomegaly, portal hypertension, and hypoxemia" and treated with splenic resection. After surgery, he began developing portal vein thrombosis. Since the patient had the classic triad of reticulate hyperpigmentation, nail dystrophy, and leukoplakia, these observations in combination with the patient's genetic testing report for hereditary diseases prepared outside our hospital led to the diagnosis of congenital dyskeratosis in our hospital. Conclusion: In the absence of any other evident reasons, when the patient presents with changes in the skin, nails, leukoplakia, etc., and multiple organ functions are affected at the same time, a diagnosis of dyskeratosis congenita should be suspected. A better understanding of the genetics underlying this rare disease condition would assist in improving its diagnosis and better monitoring disease progression and treatment.
A Four-Year Survey of Error Reports in a Radiotherapy Department
Authors: Esmati Ebrahim , Hasoomi Nafise , Khodadadi Asma , Andish Neda Maal , Ghalehtaki Reza , Kazemian Ali 
Published: April 2022

Abstract
Purpose: Patient safety is a fundamental concept in radiotherapy due to the delivery of large radiation doses in a single fraction. Radiotherapy is a highly complex procedure with many steps, which confers a high risk of errors. This study aimed to investigate radiotherapy errors and their effects on patients to provide a framework for increasing our knowledge of radiotherapy, quality of treatment and patient safety .Materials and Methods: The total number of error reports was 648 during four years of this survey (2017-2020), 51% of which were attributed to near-misses, and the patients were not affected by the errors. Also, 40% of the errors were incident errors, while the rest were non-conformity errors. Meanwhile, the number of treatment courses was 12,755, 32,118, 34,052, and 39,784 throughout the survey during 2017-2020, respectively.Results: The annual error ratio was 2.2 in 100 treatment courses. Use of a collaborative interprofessional approach led to a decrease in the incident errors by 20% and an increase in near-misses by 24% during the survey(P=.002).Conclusion: Our outcomes indicated that analyzing radiotherapy errors and their effects on patients can help radiotherapy teams, including radiation oncologists, physicists, and radiation therapists, to provide the best services for the patients; it also improves teamwork and increases the quality of treatment
A detailed limited-area energy cycle for climate and weather studies: application over the West African climate during three contrasting summers 1997 (dry), 1999 (wet) and 2006 (normal).
Authors: Ngueto Yves Franklin , Laprise René , Nikiéma Oumarou 
Published: April 2022

Abstract
The West African Monsoon (WAM) is an atmospheric circulation that involves a complex chain of interacting physical processes ranging from small to large temporal and spatial scales. In this work, a detailed atmospheric energy cycle is formulated for limited-area domains in order to understand the WAM intra-seasonal and interannual variability. The energy cycle is cast in terms of available enthalpy and kinetic energy reservoirs. According to the employed definition, the time-averaged (climate) energy reservoirs are decomposed in a component associated with the time-averaged atmospheric state and a component due to the time-averaged statistics of transient. With this approach, a storm energy is defined as the deviation of instantaneous energy from its climate value. The application of energy cycle on the simulated WAM climatology reveals that the available enthalpy of the time-averaged state (AM) is the largest energy reservoir, while the transient-eddy component (AE) is the smallest. On the other hand, the time-averaged and the time-variability kinetic energy reservoirs (KM and KE) are the same order of magnitude, confirming previous studies linking the African Easterly Waves with a mixed barotropic/baroclinic mechanism. A detailed analysis reveals that, in the time-mean state, there is a huge loss of energy flux due to time-averaged pressure work in boundary fluxes, with the result that only a little fraction of AM associated with the ageostrophic circulation contributes to the generation of KM. On the other hand, the loss of AE contributes almost entirely to the gain in KE, indicating negligible loss due to transient-eddy pressure work.
A Pandemic Crossing the Border: The Impact of Covid-19 in the US on the Mexican Labor Market
Authors: Rojas Irvin , Yu Jisang 
Published: April 2022

Abstract
The labor markets in the US and Mexico are closely linked through migrant workers and remittances. In this paper, we investigate how the prevalence of the Covid-19 epidemic in the US affected the Mexican labor market. We construct a Mexican municipality-level measure of the exposure to Covid-19 in the US using migration data. We find a positive effect of the Covid-19 exposure in the US on work hours among workers in Mexico. We also find that the effect varies across subgroups which indicates that the responses in worked hours depend on the household dynamics, employment opportunities, and the nature of the occupation-specific tasks.
A prospective analysis of two studies that used the 5-mm interval slices and 5-mm margin-free method for ipsilateral breast tumor recurrence after breast-conserving surgery without radiotherapy
Authors: Ohsumi Shozo , Nishimura Reiki , Masuda Norikazu , Akashi-Tanaka Sadako , Suemasu Kimito , Yamauchi Hideko , Tokunaga Eriko , Ikeda Tadashi , Nishi Tsunehiro , Hayashi Hiroto , Iino Yuichi , Takatsuka Yuichi , Ohashi Yasuo , Inaji Hideo 
Published: April 2022

Abstract
Background: Breast-conserving surgery with radiotherapy is one of standard treatments for early breast cancer. However, it is regarded as an option to treat elderly patients with small hormone receptor-positive breast cancer with breast-conserving surgery and hormone therapy without radiotherapy. We conducted two sequential prospective studies to examine the feasibility of breast-conserving surgery without radiotherapy since 2002 and present the results. Patients and Methods: The primary female breast cancer patients who fulfilled the strict eligibility criteria were prospectively enrolled in two sequential studies named WORTH 1 and 2. The surgical materials were sliced in 5-mm intervals and all slices were examined microscopically. Postoperative radiotherapy was not allowed, but tamoxifen or anastrozole was administered for 5 years. Ipsilateral breast tumor recurrence (IBTR)-free survival was the primary outcome.Results: The data of the two studies were combined (N = 321). The median follow-up period for IBTR was 94 months (4 – 192 months). Only 3 patients were treated with adjuvant chemotherapy. The 5- and 10-year IBTR-free rates were 97.0% and 90.5%, respectively. The age at operation and PR status affected IBTR rates independently. When we calculated IBTR-free rates of patients who were 65 years of age or older at the time of surgery and had PR-positive tumors, the 5- and 10-year IBTR rates were both 98.4%.Conclusions: Our “5-mm-thick slice and 5-mm free-margin” method may be effective to select patients who can be treated by breast-conserving surgery and hormone therapy without radiotherapy.