bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jugular venous congestion during off‐pump lung transplantation is not associated with an increased risk of postoperative delirium
Authors: Mubashir Talha , Wanderer Jonathan P. , Lambright Eric S. , Morse Jennifer , Zaki John , Choi Warren , Eltzschig Holger K. , Liang Yafen 
Published: August 2022

AbstractIntroductionDelirium occurs frequently after lung transplantation and is associated with poor clinical outcomes. Significantly prolonged jugular venous congestion (JVC) occurs during off‐pump lung transplantation and is thought to impair cerebral perfusion. Our study aimed to test the hypothesis that increased intraoperative JVC is associated with an increased risk of postoperative delirium among lung transplantation recipients.MethodsThis is a retrospective observational cohort study. Adult patients who received off‐pump lung transplantation at the Vanderbilt University Medical Center between 2006 and 2016 are included. The magnitude of JVC was calculated by the area under the curve (AUC) of the central venous pressure (CVP) above the threshold of 12 mmHg. Postoperative delirium was assessed by Confusion Assessment Method for the Intensive Care Unit (CAM‐ICU) criteria during their ICU stay. Multivariate regression analysis was used to determine the association of intraoperative JVC with postoperative delirium, adjusting for baseline demographics, surgical, and intraoperative characteristics.ResultsThirty‐two (23.5%) out of 136 patients developed delirium in the ICU. There was no statistical difference in terms of intraoperative JVC between patients with delirium and those without (4058 ± 6650 vs. 3495 ± 10 151 mmHg min; p = .772). Furthermore, during multivariate regression analysis, JVC was not associated with an increased risk of delirium (odds ratio: 1.03 per 100 mmHg min increase in venous congestion; 95% confidence interval: .31, 3.39; p = .96).ConclusionsDelirium occurred frequently after off‐pump lung transplantation. Although physiologically plausible, the present study did not find an association between increased JVC during off‐pump lung transplantation and an increased risk of postoperative delirium.
Intensive ultrafiltration strategy restores kidney transplant candidacy for patients with echocardiographic evidence of pulmonary hypertension
Authors: Earasi Kranthikiran , Mihaltses John , Kennedy Jamie L. W. , Rao Swati , Holsten Laura , Mazimba Sula , Doyle Alden , Mihalek Andrew D. 
Published: August 2022

AbstractIntroductionPulmonary hypertension (PH) is prevalent in those with end‐stage kidney disease (ESKD) and poses a barrier to kidney transplant due to its association with poor outcomes. Studies examining these adverse outcomes are limited and often utilize echocardiographic measurements of pulmonary artery systolic pressure (PASP) instead of the gold standard right heart catheterization (RHC). We hypothesized that in ESKD patients deemed ineligible for kidney transplant because of an echocardiographic diagnosis of PH the predominant cause of PH is hypervolemia and is potentially reversible.MethodsWe conducted a prospective study of 16 patients with ESKD who were denied transplant candidacy. Prior echocardiograms and RHCs were reviewed for confirmation of PH. Patients were admitted for daily sessions of ultrafiltration for volume removal and repeat RHCs were performed following intervention. RHC parameters and body weight were compared before and after intervention. Statistical analysis was performed using PRISM GraphPad software. Ap‐value <.05 was considered statistically significant.ResultsFollowing intervention, the mean pulmonary artery pressure (mPAP) and pulmonary arterial wedge pressure decreased from 45.0 ± 3.06 to 29.1 ± 7.77 mmHg (p < .0001) and 22.2 ± 5.06 to 13.1 ± 7.25 mmHg (p = .003), respectively. The pulmonary vascular resistance decreased from 4.73 ± 1.99 to 4.28 ± 2.07 WU (p = .30). Eleven patients from the initial cohort underwent successful kidney transplantation post‐intervention with 100% survival at 1‐year.ConclusionsIn ESKD patients, diagnoses of PH made by echocardiography may be largely due to hypervolemia and may be optimized using an intensive ultrafiltration strategy to restore transplant candidacy.
1029. PRUNUS MUME: Rosaceae
Authors: Moore Richard , Yoneda Kaoru 
Published: August 2022

SummaryPrunus mume (Siebold) Siebold & Zucc., a beautiful winter flowering tree with exquisite, scented flowers foretelling the arrival of spring, is illustrated; its introduction, horticultural merits and cultivation are discussed. It is native to southwest China and widely cultivated across East Asia both for its value as an ornamental tree and for its edible fruits.
1039 ZAMIA DECUMBENS: Cycadales, Zamiaceae
Authors: Herrera‐Blitman Natalia , Calonje Michael , Meerman Jan , Aguilar Rudy , Meerow Alan W. , Francisco‐Ortega Javier , Griffith M. Patrick 
Published: August 2022

SummaryZamia decumbens Calonje, Meerman, M.P.Griff. & Hoese, a threatened cycad species from Belize, is showcased and illustrated based on field observations as well as plants cultivated in the ex situ conservation living collections of Montgomery Botanical Center (MBC) in Coral Gables, Florida. This once obscure species was described in 2009, studied in the field, and introduced into ex situ conservation collections at MBC and other botanical gardens around the world. At MBC, the living collection of Z. decumbens plants has been used to conduct additional research to advance further our knowledge about cycads and to develop guidelines for building living plant collections in support of conservation. In this contribution we discuss this species and its cultivation at the ex situ conservation collection at MBC, using it to illustrate the important role botanical gardens can play in protecting threatened species and advancing our knowledge about them.
ANTWERP PRATT AND HIS PLANT COLLECTIONS
Authors: Kilpatrick Jane , Harmer Jennifer 
Published: August 2022

SummaryThe Chinese plant collections of Antwerp Edgar Pratt (1852–1924), are discussed. His early life and travels to Tachien‐lu (Kangding) in 1889 are described. As one of the first European botanists to visit this area, he collected many previously undescribed species.
Biologics for pediatric moderate‐to‐severe plaque psoriasis: a systematic review and network meta‐analysis
Authors: Huang I‐Hsin , Yu Chia‐Ling , Tai Cheng‐Chen , Tu Yu‐Kang , Chi Ching‐Chi 
Published: August 2022

SummaryBackground and ObjectivesTo compare the efficacy and safety of biologic treatments for moderate‐to‐severe pediatric psoriasis approved by the US Food and Drug Administration and European Medicines Agency.Patients and MethodsMEDLINE, Embase, and Cochrane Central Register of Controlled Trials for relevant randomized controlled trials (RCTs) were searched for the identification of eligible RCTs until May 7, 2021. Fixed‐effect frequentist network meta‐analysis (NMA) was performed with the surface under the cumulative ranking curve (SUCRA) calculated for ranking. Our primary outcomes included ≥ 90 % improvement of Psoriasis Area and Severity Index score (PASI 90) at 12–16 weeks and discontinuation owing to adverse events (DAE) through the first 12–16 weeks.ResultsFive RCTs involving 798 pediatric psoriasis patients were included. Compared to placebo, all biologic regimens exhibited a significantly higher PASI 90 response but did not differ in the risk for DAE. Based on the SUCRA, secukinumab‐low dose (SEC‐L) ranked first in the achieved PASI 90 response (84.7 %), followed by ixekizumab (70.8 %).ConclusionsAmong all biologic treatments, SEC‐L showed the best PASI 90 response without increasing the risk for DAE. More long‐term studies are warranted.
Genome‐wide analysis resolves the radiation of New Zealand's freshwater Galaxias vulgaris complex and reveals a candidate species obscured by mitochondrial capture
Authors: Campbell Ciaran S. M. , Dutoit Ludovic , King Tania M. , Craw Dave , Burridge Christopher P. , Wallis Graham P. , Waters Jonathan M. 
Published: August 2022

AbstractAimFreshwater fish radiations are often characterized by multiple closely related species in close proximity, which can lead to introgression and associated discordance of mitochondrial and nuclear characterizations of species diversity. As a case in point, single locus nuclear versus mitochondrial analyses of New Zealand's stream‐resident Galaxias vulgaris complex have yielded conflicting phylogenies. Our goal is to use genome‐wide divergence patterns among these fishes to evaluate the potential role of mitochondrial capture in obscuring species diversity, and to understand how ancient and anthropogenic drainage modification explain this diversity.LocationFreshwater ecosystems of New Zealand.MethodsWe generate and analyse a genome‐wide dataset comprising 52,352 SNPs across 187 Galaxias specimens to resolve the phylogeny of this recent fish radiation. We conduct phylogenetic, PCA, STRUCTURE, and ABBA‐BABA analyses to evaluate the evolutionary relationships of lineages in the context of natural and anthropogenic river drainage alterations.ResultsIn addition to the 11 previously recognized stream‐resident lineages, genome‐wide data reveal a twelfth candidate species (G. ‘Pomahaka’), apparently obscured by introgressive mitochondrial capture. We identify additional examples of mito‐nuclear discordance and putative mitochondrial capture, likely mediated by geological and anthropogenic modification of drainage boundaries.Main conclusionsOur study highlights the need for genome‐wide approaches for delimiting freshwater biodiversity. Genetic data also reveal the influence of drainage history on freshwater biodiversity, including the rapid divergence of recently fragmented fish populations, and the conservation genetic risks of anthropogenic translocations events.
Preschool language and visuospatial skills respectively predict multiplication and addition/subtraction skills in middle school children
Authors: Guez Ava , Piazza Manuela , Pinheiro‐Chagas Pedro , Peyre Hugo , Heude Barbara , Ramus Franck 
Published: August 2022

AbstractA converging body of evidence from neuroimaging, behavioral, and neuropsychology studies suggests that different arithmetic operations rely on distinct neuro‐cognitive processes: while addition and subtraction may rely more on visuospatial reasoning, multiplication would depend more on verbal abilities. In this paper, we tested this hypothesis in a longitudinal study measuring language and visuospatial skills in 358 preschoolers, and testing their mental calculation skills at the beginning of middle school. Language skills at 5.5 years significantly predicted multiplication, but not addition nor subtraction scores at 11.5 years. Conversely, early visuospatial skills predicted addition and subtraction, but not multiplication scores. These results provide strong support for the existence of a double dissociation in mental arithmetic operations, and demonstrate the existence of long‐lasting links between language/visuospatial skills and specific calculation abilities.
The influence of vestibular system and fetal presentation on handedness, cognitive and motor development: A comparison between cephalic and breech presentation
Authors: Hamaoui Jad , Stefaniak Nicolas , Segond Hervé 
Published: August 2022

AbstractGenetics are undoubtedly implicated in the ontogenesis of laterality. Nonetheless, environmental factors, such as the intrauterine environment, may also play a role in the development of functional and behavioral lateralization. The aim of this study was to test the Left‐Otolithic Dominance Theory (LODT; Previc, 1991) by investigating a hypothetical developmental pattern where it is assumed that a breech presentation, which is putatively associated with a dysfunctional and weakly lateralized vestibular system, can lead to weak handedness and atypical development associated with language and motor difficulties. We used the ALSPAC cohort of children from 7 to 10 years of age to conduct our investigation. Our results failed to show an association between the vestibular system and fetal presentation, nor any influence of the latter on hand preference, hand performance, or language and motor development. Bayesian statistical analyses supported these findings. Contrary to our LODT‐derived hypotheses, this study offers evidence that fetal presentation does not influence the vestibular system's lateralization and seems to be a poor indicator for handedness. Nonetheless, we found that another non‐genetic factor, prematurity, could lead to atypical development of handedness.
A randomized, double‐blind, crossover study of the effect of the fluoroquinolone moxifloxacin on glucose levels and insulin sensitivity in young men and women
Authors: Juhl Christian R. , Burgdorf Josephine , Knudsen Cecilie , Lubberding Anniek F. , Veedfald Simon , Isaksen Jonas L. , Hartmann Bolette , Frikke‐Schmidt Ruth , Mandrup‐Poulsen Thomas , Holst Jens J. , Kanters Jørgen K. , Torekov Signe S. 
Published: August 2022

AbstractAimThe voltage‐gated potassium channel Kv11.1 is important for repolarizing the membrane potential in excitable cells such as myocytes, pancreatic α‐ and β‐cells. Moxifloxacin blocks the Kv11.1 channel and increases the risk of hypoglycaemia in patients with diabetes. We investigated glucose regulation and secretion of glucoregulatory hormones in young people with and without moxifloxacin, a drug known to block the Kv11.1 channel.Materials and MethodsThe effect of moxifloxacin (800 mg/day for 4 days) or placebo on glucose regulation was assessed in a randomized, double‐blind, crossover study of young men and women (age 20‐40 years and body mass index 18.5‐27.5 kg/m2) without chronic disease, using 6‐h oral glucose tolerance tests and continuous glucose monitoring.ResultsThirty‐eight participants completed the study. Moxifloxacin prolonged the QTcF interval and increased heart rate. Hypoglycaemia was more frequently observed with moxifloxacin, both during the 8 days of continuous glucose monitoring and during the oral glucose tolerance tests. Hypoglycaemia questionnaire scores were higher after intake of moxifloxacin. Moxifloxacin reduced the early plasma‐glucose response (AUC0‐30 min) by 7% (95% CI: −9% to −4%, p < .01), and overall insulin response (AUC0‐360 min) decreased by 18% (95% CI: −24% to −11%, p < .01) and plasma glucagon increased by 17% (95% CI: 4%‐33%, p = .03). Insulin sensitivity calculated as the Matsuda index increased by 11%, and MISI, an index of muscle insulin sensitivity, increased by 34%.ConclusionsIn young men and women, moxifloxacin, a drug known to block the Kv11.1 channel, increased QT interval, decreased glucose levels and was associated with increased muscle insulin sensitivity and more frequent episodes of hypoglycaemia.
Comparing a knowledge‐based 3D reconstruction algorithm to TomTec 3D echocardiogram algorithm in measuring left cardiac chamber volumes in the pediatric population
Authors: Ahmad Attila , Shigemitsu Sachie , Termachi Yozo , Windram Jonathan , Khoo Nee , Colen Tim , Eckersley Luke 
Published: August 2022

AbstractBackgroundThree‐dimensional echocardiography (3DE) is an emerging method for volumetric cardiac measurements; however, few vendor‐neutral analysis packages exist. Ventripoint Medical System Plus (VMS3.0+) proprietary software utilizes a validated Magnetic resonance imaging (MRI) database of normal ventricular and atrial morphologies to calculate chamber volumes. This study aimed to compare left ventricular (LV) and atrial (LA) volumes obtained using VMS3.0+ to Tomtec echocardiography analysis software.MethodsHealthy controls (n = 98) aged 0–18 years were prospectively recruited and 3D DICOM datasets focused on the LV and LA acquired. LV and LA volumes and ejection fractions were measured using TomTec Image Arena 3D LV analysis package and using VMS3.0+. Pearson correlation coefficients, Bland–Altman's plots, and intraclass coefficients (ICC) were calculated, along with analysis time.ResultsThere was a very good correlation between Ventripoint Medical System (VMS) and Tomtec LV systolic (r2 = .88, ICC .89 [95% CI .81, .94]), and diastolic (r2 = .88, ICC .90 [95% CI .77, .95]) volumes, and between VMS and Tomtec LA diastolic (r2 = .75, ICC .89 [95% CI .81, .93]) and systolic (r2 = .88, ICC .91 [95% CI .78, .96]) volumes on linear regression models. Natural log transformations eliminated heteroscedasticity, and power transformations provided the best fit. The time (mins) to analyze volumes using VMS were less than using Tomtec (LV VMS 2.3 ± .5, Tomtec 3.3 ± .8, p < .001; LA: VMS 1.9 ± .4, Tomtec 3.4 ± 1.0, p < .001).ConclusionsThere was a very good correlation between knowledge‐based (VMS3.0+) and 3D (Tomtec) algorithms when measuring 3D echocardiography‐derived LA and LV volumes in pediatric patients. VMS was slightly faster than Tomtec in analyzing volumetric measurements.
Assessment of left ventricular function by spatio‐temporal image correlation in fetuses with fetal growth restriction
Authors: Ziyu Tao 
Published: August 2022

AbstractAimTo compare the evaluation of left ventricular function by spatio‐temporal image correlation (STIC) between fetal growth restriction (FGR) fetuses and normal fetuses.MethodsForty‐two FGR fetuses and 50 normal fetuses with gestational age ranging from 28 to 35 weeks, were chosen for the study group and control group, respectively. The fetal heart was acquired using the STIC modality, beginning with a four‐chamber view. A 7.5–12.5 s acquisition time and 20–35°angle of the acquisition were used for the acquisition. The resulting STIC dataset was saved for offline analysis. Ventricular volumes were measured using the Virtual Organ Computer‐aided Analysis (VOCAL) mode, where the observer defines the contours of the ventricle and traces the endocardia. Stroke volume (SV) = end diastolic volume (EDV)−end systolic volume (ESV) and ejection fraction (EF) = SV/EDV × 100%. The data of the two groups were analyzed.Results(1) SV increased with fetal growth in both groups and was positively correlated with gestational age (p < .01), whereas EF remained constant throughout gestation and had no correlation with gestational age (p > .05). (2) There was no difference found in EF between the two groups, (p > .05), SV was significantly lower in FGR group than those in the normal group (p < .01).ConclusionThe STIC is a precise method for calculating fetal ventricular volume changes and functions. Reduced SV occurred at the initial stage of fetal deterioration before the discovery of abnormal EF in FGR fetuses, indicating cardiac dysfunction. SV could be a sensitive indicator of cardiac dysfunction. The use of EF to assess fetal cardiac function is not perfect.
Transthoracic echocardiography for arrhythmic mitral valve prolapse: Phenotypic characterization as first step
Authors: Vriz Olga , Eltayeb Abdulla , Landi Irene , Anwar Kashif , Alenazy Ali , Hiristova Krassimira , Kasprzak Jarek , D'Andrea Antonello , Amro Bandar , Limongelli Giuseppe , Bossone Eduardo , Imazio Massimo 
Published: August 2022

AbstractMitral valve prolapse (MVP) is the most frequent valvulopathy with a prevalence of 1.2%–2.4% in general population and it is characterized by a benign course. Although it can be associated with some complications, ventricular arrhythmias (VA) and sudden cardiac death (SCD) as ultimate expressions, are the most worrying. The estimated risk of SCD in MVP is between 0.2% and 1.9% per year including both MVP patients with left ventricular (LV) dysfunction due to severe MR and MVP patients without significant MR. The latter ones constitute a particular phenotype called “malignant MVP” characterized by bileaflet myxomatous prolapse, ECG repolarization abnormalities and complex VAs (c‐VAs) with polymorphic/right bundle branch block morphology (RBBB) and LV fibrosis of the papillary muscles (PMs) and inferobasal wall secondary to mechanical stretching visualized as late gadolinium enhancement (LGE) areas by cardiac magnetic resonance (CMR). In MVP, the first diagnostic approach is transthoracic echocardiography (TTE) that defines the presence of mitral annular disjunction (MAD) which seems to be associated with “arrhythmic MVP” (AMVP). From an ECG point of view, AMVP is characterized by frequent premature ventricular contractions (PVCs) arising from one or both PMs, fascicular tissue, and outflow tract, as well as by T‐wave inversion in the inferolateral leads. The aim of the present paper is to describe TTE red flags that could identify MVP patients at high risk to develop complex arrhythmias as supported by the corresponding findings of LGE‐CMR and anatomy studies. TTE could be a co‐partner in phenotyping high‐risk arrhythmic MVP patients.
Activated prothrombin complex concentrate to treat bleeding events in acquired hemophilia A: BAHAS study
Authors: Mingot‐Castellano María E. , García‐Candel Faustino , Benítez‐Hidalgo Olga , Marco Ana , Méndez Navarro Gala A. , Pérez‐Montes Rocío , García Donas Gloria , Canaro Mariana , Paloma María J. , Asenjo Beatríz , Calle‐Gordo Victoria M. , González Noelia P. , Rodríguez González Ramón , Caparrón‐Miranda Isabel S. , Quintana París Laura , Herrero Sonia , Nuñez Ramiro 
Published: August 2022

AbstractObjectiveActivated prothrombin complex concentrate (aPCC) is a bypassing agent indicated to treat bleeds in patients with acquired hemophilia A (AHA). Nevertheless, its efficacy and safety in the real‐world setting have not often been addressed.MethodsWe report the experience of Spanish reference centers for coagulation disorders and from acquired hemophilia Spanish Registry (AHASR) from August 2012 to February 2021. Follow‐up period of 30 days after aPCC withdrawal.ResultsThirty patients with a median age of 70 years old, suffering from 51 bleeds treated with aPCC were finally evaluated. As first‐line treatment, aPCC stopped bleeding in 13 of 14 (92.9%) cases. aPCC as the second line after recombinant factor VIIa failure, stopped bleeding in all cases. In 17 patients, aPCC was used far from initial bleed control as prophylaxis of rebleeding with 94% effectiveness. No thromboembolic episodes were communicated. One patient developed hypofibrinogenemia, which did not prevent aPCC from halting bleeding. No other serious adverse events possibly or probably associated with aPCC were reported.ConclusionsThis data support aPCC as hemostatic treatment in AHA with high effectiveness and excellent safety profile in acute bleeds and as extended use to prevent rebleedings, even in aging people with high cardiovascular risk.
Ecological lags govern the pace and outcome of plant community responses to 21st‐century climate change
Authors: Block Sebastián , Maechler Marc‐Jacques , Levine Jacob I. , Alexander Jake M. , Pellissier Loïc , Levine Jonathan M. 
Published: August 2022

AbstractForecasting the trajectories of species assemblages in response to ongoing climate change requires quantifying the time lags in the demographic and ecological processes through which climate impacts species' abundances. Since experimental climate manipulations are typically abrupt, the observed species responses may not match their responses to gradual climate change. We addressed this problem by transplanting alpine grassland turfs to lower elevations, recording species' demographic responses to climate and competition, and using these data to parameterise community dynamics models forced by scenarios of gradual climate change. We found that shifts in community structure following an abrupt climate manipulation were not simply accelerated versions of shifts expected under gradual warming, as the former missed the transient rise of species benefiting from moderate warming. Time lags in demography and species interactions controlled the pace and trajectory of changing species' abundances under simulated 21st‐century climate change, and thereby prevented immediate diversity loss.