bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum levels of glial fibrillary acidic protein in patients with amyotrophic lateral sclerosis
Authors: Verde Federico , Milone Ilaria , Maranzano Alessio , Colombo Eleonora , Torre Silvia , Solca Federica , Doretti Alberto , Gentile Francesco , Manini Arianna , Bonetti Ruggero , Peverelli Silvia , Messina Stefano , Maderna Luca , Morelli Claudia , Poletti Barbara , Ratti Antonia , Silani Vincenzo , Ticozzi Nicola 
Published: December 2022

AbstractObjectiveTo compare serum levels of the astrocyte biomarker glial fibrillary acidic protein (GFAP) in patients with amyotrophic lateral sclerosis (ALS) and neurologically healthy controls and to analyze the relations between serum GFAP (sGFAP) and phenotype in ALS.MethodsWe studied 114 ALS patients and 38 controls. sGFAP was quantified with single molecule array (Simoa) technology.ResultsIn both ALS patients and controls, sGFAP moderately correlated with age. ALS patients had higher sGFAP levels compared to controls, but this yielded a weak discriminative performance (AUC = 0.6198). In ALS, sGFAP was not associated with most of the motor phenotypic features, including site of onset, functional status, disease progression rate, disease stage, and indices of upper (UMN) and lower motor neuron (LMN) impairment. However, sGFAP negatively correlated with cognitive scores regarding ALS‐nonspecific functions, particularly memory (r = −0.2082) and tended to be higher in ALS patients with eye movement abnormalities (p = 0.0628). sGFAP also correlated with polysomnographic indices of oxygen desaturation (ODI; r = 0.2639) and apnea‐hypopnea (AHI; r = 0.2858). In a multivariate analysis, sGFAP was negatively associated with survival (HR = 1.005). Relevantly, we found a negative correlation between sGFAP and estimated glomerular filtration rate (eGFR; r = −0.3500).InterpretationOur work provides neurochemical evidence of astrocyte involvement in ALS pathophysiology and particularly in the development of extra‐motor manifestations (namely, cognitive – memory – impairment) and respiratory dysfunction. The negative correlation between sGFAP and eGFR has practical relevance and should not be disregarded in future investigations.
Realizing Highly Efficient Sonodynamic Bactericidal Capability through the Phonon–Electron Coupling Effect Using Two‐Dimensional Catalytic Planar Defects
Authors: Mao Congyang , Jin Wanyu , Xiang Yiming , Zhu Yizhou , Wu Jun , Liu Xiangmei , Wu Shuilin , Zheng Yufeng , Cheung Kenneth M. C. , Yeung Kelvin Wai Kwok 
Published: December 2022

AbstractConferring catalytic defects in sonosensitizers is of paramount importance in reinforcing sonodynamic therapy. However, the formation of such 0D defects is governed by the Schottky defect principle. Herein, 2D catalytic planar defects are designed within Ti3C2 sheets to address this challenge. These specific planar slip dislocations with abundant Ti3+ species (Ti3C2‐SD(Ti3+)) can yield surface‐bound O due to the effective activation of O2, thus resulting in a substantial amount of 1O2 generation and the 99.72% ± 0.03% bactericidal capability subject to ultrasound (US) stimulation. It is discovered that the 2D catalytic planar defects can intervene in electron transfer through the phonon drag effect—a coupling effect between surface electrons and US‐triggered phonons—that simultaneously contributes to a dramatic decrease in O2 activation energy from 1.65 to 0.06 eV. This design has achieved a qualitative leap in which the US catalytic site has transformed from 0D to 2D. Moreover, it is revealed that the electron origin, electron transfer, and visible O2 activation pathway triggered by US can be attributed to the phonon–electron coupling effect. After coating with neutrophil membrane (NM) proteins, the NM‐Ti3C2‐SD(Ti3+) sheets further demonstrate a 6‐log10 reduction in methicillin‐resistant Staphylococcus aureus burden in the infected bony tissue.
Circumventing Challenges: Design of Anodic Electrocatalysts for Hybrid Water Electrolysis Systems
Authors: Wang Hao‐Yu , Sun Ming‐Lei , Ren Jin‐Tao , Yuan Zhong‐Yong 
Published: December 2022

AbstractWater electrolysis, driven by renewable energy resources, is a promising energy conversion technology that has gained intensive interest in recent years. However, conventional water electrolysis faces a number of challenges, including large thermodynamic potential gaps, valueless anodic products, explosive hydrogen/oxygen mixtures, reactive oxygen species, and limited pure water. Hybrid water electrolysis, appending different electrolytes in the anode compartment to circumvent the above‐mentioned challenges in conventional water electrolysis, is a particularly attractive alternative. In this review, for the first time, a holistic and subtle description of hybrid water electrolysis is provided, focusing on the design of high‐activity/selectivity/stability anodic electrocatalysts for the electrochemical oxidation of various chemicals, such as alcohol, aldehyde, amine, urea and hydrazine, or the oxygen evolution reaction in seawater electrolytes. Comprehensive judging criteria for anodic oxidation reactions, electrocatalysts, and reaction parameters in hybrid water electrolysis are discussed. Some technoeconomic assessments, feasibility analyses, mechanism explorations, and correlation comparisons are involved. Finally, perspectives on and opportunities for future research directions in hybrid water electrolysis systems are outlined.
Cutaneous Nrf2‐Keap1 pathway modulation by environmental factors: The Dead Sea area as a test case
Authors: Cohen Dror , Portugal‐Cohen Meital , Oron Miriam , Frusic‐Zlotkin Marina , Soroka Yoram , Ma'or Ze'evi , Amar Dalit , Kohen Ron 
Published: December 2022

AbstractThe skin is constantly exposed to exogenous environmental stressors and has to cope with excessive oxidative stress and tissue damage. However, exposure to moderate environmental stressors may be beneficial for the cutaneous tissue and assist in protecting against oxidative damage via the enhanced activation of the nuclear factor erythroid 2‐related factor 2–Kelch‐like ECH‐associated protein 1 (Nrf2–Keap1) pathway. Such moderate stressors can be found in various locations around the globe. In this manuscript, we chose to focus on the Dead Sea (DS) area as a test case to study the effect of moderate stressors on the cutaneous tissue because of the unique combinations of moderate stressors in this area. The exceptional location of the DS at an altitude of −438 meters below sea level (the lowest place on earth) is responsible for its rare accumulation of moderate stressors such as high‐water salinity, high atmospheric pressure, and unique solar radiation. In this manuscript, we hypothesized that the unique solar radiation in the DS area generates moderate oxidative stress in the skin leading to the induction of intracellular electrophiles, which in turn can activate the protecting Nrf2‐Keap1 pathway. We showed that exposure of human skin organ culture from the same donor to solar radiation at the DS resulted in significant activation of the Nrf2‐Keap1 pathway, induction of phase II enzymes, and lower apoptotic activity compared to a nearby location at a higher altitude (Jerusalem +700 m). This remarkable effect of activating the Nrf2 protecting pathway and the importance and characteristics of the solar irradiation at the DS is discussed.
Nanorod/nanodisk‐integrated liquid crystalline systems for starvation, chemodynamic, and photothermal therapy of cancer
Authors: Kim Sungyun , Hwang ChaeRim , Jeong Da In , Park JiHye , Kim Han‐Jun , Lee KangJu , Lee Junmin , Lee Seung‐Hwan , Cho Hyun‐Jong 
Published: December 2022

AbstractIndocyanine green (ICG), glucose oxidase (GOx), and copper(II) sulfate (Cu)‐installed hybrid gel based on organic nanorod (cellulose nanocrystal [CNC]) and inorganic nanodisk (Laponite [LAP]) was developed to perform a combination of starvation therapy (ST), chemodynamic therapy (CDT), and photothermal therapy (PTT) for localized cancers. A hybrid CNC/LAP network with a nematic phase was designed to enable instant gelation, controlled viscoelasticity, syringe injectability, and longer in vivo retention. Moreover, ICG was introduced into the CNC/LAP gel system to induce hyperthermia of tumor tissue, amplifying the CDT effect; GOx was used for glucose deprivation (related to the Warburg effect); and Cu was introduced for hydroxyl radical generation (based on Fenton‐like chemistry) and cellular glutathione (GSH) degradation in cancer cells. The ICG/GOx/Cu‐installed CNC/LAP gel in combination with near‐infrared (NIR) laser realized improved antiproliferation, cellular reactive oxygen species (ROS) generation, cellular GSH degradation, and apoptosis induction in colorectal cancer (CT‐26) cells. In addition, local injection of the CNC/ICG/GOx/Cu/LAP gel into the implanted CT‐26 tumor while irradiating it with NIR laser provided strong tumor growth suppression effects. In conclusion, the designed hybrid nanorod/nanodisk gel network can be efficiently applied to the local PTT/ST/CDT of cancer cells.
Comprehensive analysis of the prognostic impact and immune implication of KIAA1429 in lung adenocarcinoma
Authors: Guo Lei , Huai Qilin , Zhou Bolun , Ying Jianming , Guo Wei 
Published: December 2022

AbstractBackgroundLung adenocarcinoma (LUAD) is the most common lung cancer worldwide. N6‐methyladenosine (m6A) methylation is a messenger RNA (mRNA) modification that plays a key role in tumor growth, immune microenvironment, and immunotherapy response. This study investigated the expression level, mutation status, prognostic value, and predictive ability for response to anti‐PD‐1 immunotherapy of the m6A methyltransferase KIAA1429 in LUAD.MethodsThis study examined multiple public data cohorts and independent samples from National Cancer Center (NCC) to evaluate the clinical significance and prognostic value of KIAA1429 in LUAD using bioinformatics techniques and immunohistochemical staining. We also evaluated the predictive value of KIAA1429 expression for anti‐PD‐1 immunotherapy efficacy. GSEA analysis was performed using KIAA1429 RNA‐seq data at the tumor tissue level and cellular level to explore the potential molecular mechanism.ResultsIn public databases, KIAA1429 was significantly associated with clinicopathological parameters in LUAD patients and had the potential to predict patient prognosis. The mutation characteristics of KIAA1429‐related genes were analyzed and TP53, TTN, CSMD3, and other genes showed high mutation frequencies in LUAD. An independent cohort of 415 samples confirmed that high KIAA1429 expression was significantly associated with poorer prognosis in LUAD patients. Analysis of a small immunotherapy cohort showed that patients with high expression of KIAA1429 had better response after immunotherapy, and the proportion of patients with immunotherapy response was higher in this group.ConclusionsOur study confirmed that KIAA1429 was highly expressed in LUAD and was significantly associated with poor prognosis. Moreover, KIAA1429 may serve as a potential marker to predict the efficacy of immunotherapy in LUAD.
Evaluation of quality of clinical management of neuroendocrine tumors
Authors: Bloemen Hannah , Kneepkens Kristien , Deraedt Karen , Ivanova Anna , Sergeant Gregory , Mebis Jeroen , Van der Speeten Kurt 
Published: December 2022

AbstractBackgroundNeuroendocrine tumors (NETs) are a group of biologically and clinically heterogeneous neoplasms predominantly found in the gastrointestinal and bronchopulmonary tractus. Despite a rising incidence, implementation of evidence‐based standardized care for this heterogenous group remains challenging. The European Neuroendocrine Tumor Society regularly reviews guidelines regarding diagnostic and treatment strategies for NETs. The aim of this study is to shed light on the care of patients with a NET in Belgian Limburg, to provide data as a basis for future studies and to check whether data and results are according to consensus guidelines and outcomes described in literature.MethodsOur study concerned a detailed observational data collection of two large Belgian hospitals (Jessa Hospital Hasselt and Hospital Oost‐Limburg Genk) with special interest in patient profile, quality of pathology reports, use of diagnostic imaging, and overall survival. Data on 188 patients were assembled between January 2010 and December 2014 with follow‐up until June 2016 (median follow‐up: 33.6 months).ResultsFifty percent of patients were male. NETs were located mainly in the digestive tract (63.8%) and lung (20.2%). Appendiceal NETs were diagnosed at a significantly younger age than other tumors (41.3 vs. 64.0 years). Overall, a mean pathology report quality score of 3.0/5 was observed with the highest scores for small bowel NETs. Diagnostic and nuclear imaging was performed in 74.5% and 29.8% of cases, respectively. Seventy‐four percent of the population survived until the end of the observation period with highest survival rates for appendiceal and small bowel NETs.ConclusionOverall, epidemiological results were comparable with findings in the literature. Gastrointestinal NETs met most of the requirements of qualitative pathology reporting and diagnostic imaging as listed in the European Neuroendocrine Tumor Society consensus guidelines. However, consensus with regard to bronchopulmonary NETs is still scarce and remains an objective for future research. Moreover, discussing treatment strategies in specialized multidisciplinary tumor boards would facilitate regional care.
Deactivation of Pd6Cr4@NH2‐MIL‐101 Catalyst in Dehydrogenation of Formic Acid
Authors: Zhang Youhua , Duan Linhai , Yang Ping , Zhang Dan , Meng Xiuhong 
Published: December 2022

AbstractDeactivation of Pd‐Cr bimetallic nanopaticles supported on NH2‐functionalized MIL‐101 in dehydrogenation of formic acid is studied. Results show that the catalyst cannot be reused more than three times because the concentration of carbon monoxide in the gaseous product will exceed 10 ppm. When the catalyst is used for the first time, the turnover frequency of the active metal Pd is the highest. With an increase of catalyst utilization times, the turnover frequency decreases. The reason for the reduction in catalyst activity is agglomeration of Pd and Cr atoms on the outer surface of the catalyst, not because the active component, Pd, is being lost.
Hydrodynamics Study on Annular Centrifugal Contactors: CINC V 02 as an Example
Authors: Hamamah Zaid Al-khier , Grützner Thomas 
Published: December 2022

AbstractAlthough annular centrifugal extractors (ACCs) have been increasingly applied in the process industry recently, their complex fluid dynamics is still not fully explained in the literature. This could be one of the major reasons why their current industrial implementation is not up to their potential. This work aims to enhance the understanding of ACC hydrodynamics by focusing on liquid holdup and distribution in the variant CINC V 02. First, several sources causing holdup variation are investigated with the help of a model simulating the liquid surface inside the device. Then, the factors determining liquid content in both chambers are presented. The standard shut‐down procedure to measure holdup is eventually elaborated on, and an improved procedure is proposed.
A Quasi‐Solid Electrolyte by In Situ Polymerization of Selective Solvent for Lithium‐Metal Batteries
Authors: Wang Jin , Tao Chengzhou , Cao Jiaming , Jiao Xiaoxia , Wang Lina , Liu Tianxi 
Published: December 2022

AbstractLithium (Li) metal is a competitive anode material for rechargeable high energy density batteries due to its high specific capacity and low reduction potential. However, great challenges remain in addressing uncontrollable Li dendrite growth and unstable interface. Herein, we report a quasi‐solid electrolyte enabled by in situ polymerization of polyethylene glycol methyl ether acrylate. Meanwhile, a LiF‐enriched solid electrolyte interphase (SEI) is built on Li‐metal surface by function of the fluoroethylene carbonate additive. The SEI with a good mechanical stability prompts the dense and uniform Li deposition behavior. The in situ polymerized gel polymer electrolyte exhibits an ionic conductivity of 1.71×10−4 S cm−1 at 30 °C, and a considerable oxidative stability up to 4.5 V (vs. Li/Li+). The Li||Li symmetric cells delivers a long‐term cycle life over 1400 h and a low voltage hysteresis at 0.5 mA cm−2, 1 mAh cm−2. To be paired with a LiFePO4 positive electrode, the cell shows a high discharge capacity of 135.6 mAh g−1 and capacity retention of 92.7 % after 300 cycles. This work provides a reference for the practical development of quasi‐solid electrolyte for lithium‐metal battery.
Ammonia Modified MXene/Aniline Copolymers Electrochemical Sensors for Ultrasensitive Sensing Glutathione
Authors: Liu Guangyan , Xia Tianzi , Wei Jiaxin , Hou Shili , Hou Shifeng 
Published: December 2022

AbstractHerein, unique ammonia modified MXene/aniline copolymers (PTA) are prepared by facile and green electropolymerization with the rose‐like ammonia modified MXene (N‐Ti3C2Tx) and aniline to modify electrochemical sensor to detect GSH with high performance. Scanning electron microscopy (SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) characterizations show that the PTA copolymer exhibits a net‐like structure and excellent electrochemical performance. It displays that the PTA can be regarded as an outstanding electrode nanomaterial for high‐performance sensors. Moreover, the PTA/GCE biosensor is fabricated through one‐step electropolymerization method for detecting glutathione. Under the optimum conditions, the limit of detection of the biosensor is calculated to be 5.21×10−14 mol L−1 with a high sensitivity of 32.9 μA nmol−1 L cm−2. At the same time, the biosensor displays excellent selectivity and stability. Furthermore, the fabricated PTA/GCE biosensor is applied to detect glutathione of plasma samples with good recoveries, indicating that the sensor has broad application prospects in the field of biological and medical analysis.
Influence of AlPO4 Impurity on the Electrochemical Properties of NASICON‐Type Li1.5Al0.5Ti1.5(PO4)3 Solid Electrolyte
Authors: Campanella Daniele , Krachkovskiy Sergey , Faure Cyril , Zhu Wen , Feng Zimin , Savoie Sylvio , Girard Gabriel , Demers Hendrix , Vijh Ashok , George Chandramohan , Armand Michel , Belanger Daniel , Paolella Andrea 
Published: December 2022

AbstractDensification of ceramic electrolytes is a key enabler in producing electrolyte pellets for solid‐state batteries. This requires understanding the correlation between the starting grain size of electrolytes, chemical phase evolution and degree of compaction which determine ion conductivity and chemical stability of solid electrolytes. In our work we were able to optimize the densification process of LATP at 700 °C with a high total ionic conductivity of 3.45×10−4 S cm−1 after hot pressing, balancing pristine LATP crystallite size and AlPO4 impurity formation. By combining several techniques such as in situ heating X‐ray diffraction (XRD), scanning electron microscopy (SEM) and nuclear magnetic resonance (NMR), we explored the formation mechanism of AlPO4 during the synthesis process of NASICON‐type Li1.5Al0.5Ti1.5(PO4)3 (LATP) electrolyte and we showed the effects of the annealing temperature on the crystal size of the material. Density functional theory (DFT) calculations on the chemical stability of the electrolyte imply a metastable behaviour of LATP furtherly enhanced by particle nano‐structuring at high temperature. Our results point to facile manufacturing of ceramic electrolytes towards energy dense and safe solid‐state battery technology.
Hierarchical MoO3‐MnNi LDH@Cu(OH)2 Core‐Shell Nanorod Arrays Constructed through In‐Situ Oxidation Combined with a Hydrothermal Strategy for High‐Performance Energy Storage
Authors: Cheng Wenting , Huang Wenjun , Zhang Aitang , Du Yiqi , Cui Liang , Tian Pengfei , Liu Jingquan 
Published: December 2022

AbstractThe synthesis of layered nanorod arrays with a core‐shell structure is considered to be a viable strategy to improve the electrochemical property of electrode materials. Herein, we have successfully designed and fabricated layered MoO3‐MnNi LDH@Cu(OH)2/CF(MO‐MN LDH@COH) core‐shell nanorods through a handy in‐situ oxidation reaction followed by a hydrothermal synthesis, which consist of ordered Cu(OH)2 nanorods and ultra‐thin MoO3‐MnNi LDHs nanosheets. The MO‐MN LDH@COH which is utilized as the cathode in three electrodes exhibits superior electrochemical property. The specific capacity of prepared electrode is 16913 mF cm−2 under a current density of 2 mA cm−2, which is superior to its counterparts of COH, MN LDH@COH‐0, MO‐MN LDH@COH‐0.5 and MO‐MN LDH@COH‐2. What's more, the cycling stability reaches 83.33 % capacitance retention after 5000 cycles under the current density of 30 mA cm−2. When a solid‐state asymmetric supercapacitor (ASC) device (MO‐MN LDH@COH//AC) is fabricated, it could keep a household LED screen running for 27 minutes, verifying the immense commercial potential. Overall, this unique MO‐MN LDH@COH nanocomposite with excellent electrochemical performance should envision great practical application potential.
Determination of object‐specific traffic‐load‐models for existing road bridges based on traffic data
Authors: Freundt Ursula , Böning Sebastian , Pelke Eberhard 
Published: December 2022

AbstractFor an assessment of the necessity, the efficiency and the prioritization of repair and upgrading measures for bridges, object‐specific knowledge of structural stresses and structural conditions is indispensable. From the identification of traffic occupancy (quantity and quality) and the analysis of the structural reactions, statements on the current load‐bearing capacity of an existing bridge will derived. A necessary data basis is the traffic data of the real traffic determined for the specific bridge.
Effect of Hepatic Impairment on OATP1B Activity: Quantitative Pharmacokinetic Analysis of Endogenous Biomarker and Substrate Drugs
Authors: Lin Jian , Kimoto Emi , Yamazaki Shinji , Vourvahis Manoli , Bergman Arthur , Rodrigues A. David , Costales Chester , Li Rui , Varma Manthena V. S. 
Published: December 2022

Hepatic impairment (HI) is known to modulate drug disposition and may lead to elevated plasma exposure. The aim of this study was to quantitate the in vivo OATP1B‐mediated hepatic uptake activity in populations with varying degrees of HI. First, we measured baseline levels of plasma coproporphyrin‐I, an endogenous OATP1B biomarker, in an open‐label, parallel cohort study in adult subjects with normal liver function and mild, moderate, and severe HI (n = 24, 6/cohort). The geometric mean plasma concentrations of coproporphyrin‐I were 1.66‐fold, 2.81‐fold (P < 0.05), and 7.78‐fold (P < 0.0001) higher in mild, moderate, and severe impairment than those healthy controls. Second, we developed a dataset of 21 OATP1B substrate drugs with HI data extracted from literature. Median disease‐to‐healthy plasma area under the curve (AUC) ratios for substrate drugs were ~ 1.4, 3.0, and 6.4 for mild, moderate, and severe HI, respectively. Additionally, significant linear relationship was noted between AUC ratios of substrate drugs without and with co‐administration of rifampin, a prototypic OATP1B inhibitor, and AUC ratios in moderate (P < 0.01) and severe (P < 0.001) HI. Third, a physiologically‐based pharmacokinetic model analysis was conducted with 10 substrate drugs following estimation of relative OATP1B functional activity in virtual disease population models using coproporphyrin‐I data and verification of substrate models with rifampin drug–drug interaction data. This approach adequately predicted plasma AUC change particularly in moderate (9 of 10 within 2‐fold) and severe (5 of 5 within 2‐fold) HI. Collective findings indicate progressive reduction, by as much as 90–92%, in OATP1B activity in the HI population.