bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of the combined symptom and medication score with quality of life, symptom severity and symptom control in allergic rhinoconjunctivitis
Authors: Palathumpattu Binoy , Pieper‐Fürst Ursula , Acikel Cengizhan , Sahin Hacer , Allekotte Silke , Singh Jaswinder , Hess Mark , Sager Angelika , Müller Thomas , Mösges Ralph 
Published: October 2022

AbstractBackgroundThe European Academy of Allergy and Clinical Immunology recommended the Combined Symptom and Medication Score (CSMS) as primary endpoint in clinical trials on allergen‐specific immunotherapy (AIT) in allergic rhinoconjunctivitis. Here, the correlation between the CSMS and the validated standardised Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ(S)), Rhinitis Control Assessment Test (RCAT) and Visual Analogue Scale (VAS) was analysed.MethodsTwo prospective, multicentre, non‐interventional studies on tree pollen, grass pollen and house dust mite allergic patients were performed. The first study comprised 167 patients receiving AIT (AIT population), and the second included 56 patients treated with symptomatic medication only (control population). For up to two seasons (pollen)/exposure periods (house dust mites), participants documented their symptoms and medication intake in a CSMS diary, including VAS. In addition, the standardised RQLQ(S) and the RCAT were completed during study visits.ResultsComparison between CSMS and RQLQ(S) revealed a positive correlation in the AIT population (r = 0.426) and in the control population (r = 0.569). For CSMS and RCAT, a negative correlation with r = −0.409 (AIT) and r = −0.547 (control) was shown. Positive correlation between CSMS and VAS was also demonstrated with r = 0.585 (AIT) and r = 0.563 (control).ConclusionThese results support the assumption that the CSMS correlates with quality of life, symptom severity and symptom control on the one hand, while the moderate strength of correlations on the other hand mirrors distinctions of the CSMS compared to the assessments used here.
Management of anaplastic thyroid cancer and proposed treatment guidelines—A 5‐year case series study
Authors: Koda Kento , Katoh Mitsuhiko , Yasuhara Kazuo 
Published: October 2022

AbstractBackgroundAnaplastic thyroid cancer is a rare and rapidly progressive cancer with an extremely poor prognosis. Besides surgical control, no clear treatment has been found, mainly due to the small population affected and high mortality rate.AimsTo propose evidence‐based treatment guidelines based on a 5‐year retrospective study of patients with anaplastic thyroid cancer treated at our facility. There have been no clearly defined guidelines for treatment plan for undifferentiated thyroid cancer. Our paper presents a retrospective analysis on the treatment of patients with undifferentiated thyroid cancer at our hospital.Methods and ResultsWe retrospectively evaluated the data of patients diagnosed with anaplastic thyroid cancer from April 2017 to March 2022. The total number of patients diagnosed and treated was seven. Two of these patients had operable cancer; five were inoperable and treated with lenvatinib or paclitaxel maintenance therapy. The median time from the first visit to death was 3.84 months, and six of the seven patients died before this study started. Three of them had Stage IVB cancer and died due to deterioration of their general condition, including lung metastasis; the other three had Stage IVC cancer and died of suffocation. The survivor had Stage IVB cancer, was treated by surgery combined with chemical radiotherapy, and survived >240 days.ConclusionConsidering the above findings, personalized surgical treatment should be prioritized to prevent suffocation. Especially in Stage IVB cancer, local control can be achieved by surgical and anticancer drug treatment to avoid death from suffocation.
Anisotropic 1H STD‐NMR Spectroscopy: Exploration of Enantiomer‐Polypeptide Interactions in Chiral Oriented Environments
Authors: Gouilleux Boris , Moussallieh Francois‐Marie , Lesot Philippe 
Published: October 2022

AbstractWe explore and report for the first time the use of 1H saturation transfer difference NMR experiments (STD‐NMR) in weakly aligning chiral anisotropic media to identify the hydrogen sites of enantiomers of small chiral molecules interacting with the side‐chain of poly‐γ‐benzyl‐l‐glutamate (PBLG), a helically chiral polypeptide polymer. The first experimental results obtained on three model mono‐stereogenic compounds outcomes are highly promising and demonstrate the possibility to track down possible differences of spatial position of enantiomers at the vicinity of the polymer side‐chain. Anisotropic STD experiments appear to be well suited for rapid screening of chiral analytes that bind favorably to orienting polymeric systems, while providing new insights into the mechanism of enantio‐discrimination without resorting to the time‐consuming determination of molecular order parameters.
Chirality Transfer from an Innately Chiral Nanocrystal Core to a Nematic Liquid Crystal 2: Lyotropic Chromonic Liquid Crystals
Authors: Gonçalves Diana P. N. , Ogolla Timothy , Hegmann Torsten 
Published: October 2022

AbstractThe importance of and the difference between molecular versus structural core chirality of substances that form nanomaterials, and their ability to transmit and amplify their chirality to and within a surrounding condensed medium is yet to be exactly understood. Here we demonstrate that neat as well as disodium cromoglycate (DSCG) surface‐modified cellulose nanocrystals (CNCs) with both molecular and morphological core chirality can induce homochirality in racemic nematic lyotropic chromonic liquid crystal (rac‐N‐LCLC) tactoids. In comparison to the parent chiral organic building blocks, D‐glucose, endowed only with molecular chirality, both CNCs showed a superior chirality transfer ability. Here, particularly the structurally compatible DSCG‐modified CNCs prove to be highly effective since the surface DSCG moieties can insert into the DSCG stacks that constitute the racemic tactoids. Overall, this presents a highly efficient pathway for chiral induction in an aqueous medium and thus for understanding the origins of biological homochirality in a suitable experimental system.
The effect of sustainable business practices on profitability. Accounting for strategic disclosure
Authors: Cerciello Massimiliano , Busato Francesco , Taddeo Simone 
Published: October 2022

AbstractThis work tackles from an empirical perspective the widely debated relationship between sustainability in business practices and profitability, focusing on a sample of listed European firms. To measure the extent of sustainable practices at the firm level, the Comprehensive Environmental, Social, and Governance (ESG) score is proposed. The indicator, computed using the Mazziotta‐Pareto method, combines qualitative ratings on adherence to ESG standards with quantitative observations on the extent of data disclosure. Firms failing to pursue full disclosure are penalized. Focusing on the constituents of the Euro Stoxx 300 index, a dynamic panel model is implemented, where profitability is explained by the indicator. The results show that sustainability in business practices reduces profitability. These findings are in line with a strand of literature that highlights the role of strategic disclosure of ESG information on part of firms. Strategic disclosure occurs as a combination of greenwashing and social washing, with firms overstating the extent of their positive behaviors. The integration of sustainable practices within successful business models thus remains a relevant societal problem. The current EU policy framework is discussed in line with our findings.
Plant diversity and functional identity alter ant occurrence and activity in experimental grasslands
Authors: Achury Rafael , Clement Lars , Ebeling Anne , Meyer Sebastian , Voigt Winfried , Weisser Wolfgang W. 
Published: October 2022

AbstractIncreasing plant species richness has been shown to positively affect the diversity of a range of other organisms, both above‐ and belowground. Although ants have a multitude of interactions with other organisms through their role as predators and mutualists, ants are a taxon that has rarely been investigated in studies of biodiversity effects. Ants are known to respond to changes in microclimatic conditions such as temperature and humidity, and these microclimatic conditions are known to be affected by vegetation characteristics such as standing biomass, which in turn can be affected by plant diversity. We investigated the effects of plant species richness (1–60), the number of plant functional groups (FGs; 1–4), and the presence of particular FGs on the occurrence and activity of ants, in the context of a grassland biodiversity experiment. Ant abundance, estimated as the mean number of workers in pitfall traps, and the number of colonies within plots, but not ant species richness, were negatively affected by plant species richness, and also by the identity of plant FGs, particularly legumes (negative effects) and grasses (positive effects). Statistical approaches showed that these effects were largely mediated by biotic (aboveground plant biomass: negative effect) and abiotic variables (soil temperature: positive effect). Notably, ant activity, measured as the mean number of workers foraging on baits and with a disproportionate dominance of a single species (Lasius niger), showed a more complex pattern, where plant species richness and number of FGs interacted to explain differential attractiveness to different resources (represented by sugar and tuna baits), likely representing current nutritional requirements for ants. Similarly, increasing soil temperature increased the level of ant activity, indicating that abiotic factors might impose thermal constraints on ectotherms inhabiting temperate grasslands. Our results indicate that a higher number of plant species and higher plant biomass had a negative effect on ants in experimental grasslands. Understanding the responses of an ecologically important group such as ants will allow us to infer the effects that biodiversity loss could have on animal‐mediated ecosystem processes.
Management of severe hypercalcaemia secondary to primary hyperparathyroidism: The efficacy of saline hydration, furosemide, and zoledronic acid
Authors: Oueslati Ibtissem , Kardi Asma , Yazidi Meriem , Abidi Sahar , Chaker Fatma , Mellassi Seifeddine , Chihaoui Melika 
Published: October 2022

AbstractIntroductionSevere hypercalcaemia is a life‐threatening condition that should be managed urgently. The aim of this study was to assess the efficacy of saline hydration, furosemide, and zoledronic acid in the management of severe hypercalcaemia secondary to primary hyperparathyroidism (PHPT).MethodsWe conducted a retrospective analysis of the management of 65 patients with severe hypercalcaemia (≥3 mmol/L) secondary to PHPT. The efficacy of each therapeutic agent was evaluated according to the variation in serum calcium level calculated as Δ calcium = initial calcium level – minimal calcium level reached after the administration of each agent.ResultsThe mean age of patients was 56.4 ± 13.8 years. At baseline, the mean total serum calcium level was 3.42 ± 0.40 mmol/L. After normal saline hydration, calcium level decreased from 3.25 ± 0.21 to 2.98 ± 0.2 mmol/L (p < 10−3) in 3.1 ± 1.7 days. Normalization of calcium level did not occur in any patient. Furosemide was prescribed in 35 patients. It resulted in a serum calcium increase of 0.09 ± 0.21 mmol/L. Calcium levels did not reach the normal range in any patient. Forty‐five patients received intravenous zoledronic acid. The mean maximal reduction in serum calcium level was 0.57 ± 0.27 mmol/L (from 3.25 ± 0.26 mmol/L to 2.68 ± 0.22 mmol/L, p‐value <10−3). Normalization of calcium levels occurred in 27 patients (60%).ConclusionsOur results show the absence of a significant additional effect of furosemide on calcium levels in patients with severe hypercalcaemia secondary to PHPT when compared with the effect of saline hydration alone. However, zoledronic acid was more potent. Thus, appropriate normal saline hydration with immediate intravenous bisphosphonates infusion should be considered in the management of severe hypercalcaemia in patients with PHPT.
Association of epicardial adipose tissue with proteomics, coronary flow reserve, cardiac structure and function, and quality of life in heart failure with preserved ejection fraction: insights from the PROMIS‐HFpEF study
Authors: Venkateshvaran Ashwin , Faxen Ulrika Ljung , Hage Camilla , Michaëlsson Erik , Svedlund Sara , Saraste Antti , Beussink‐Nelson Lauren , Fermer Maria Lagerstrom , Gan Li‐Ming , Tromp Jasper , Lam Carolyn S.P. , Shah Sanjiv J. , Lund Lars H. 
Published: October 2022

ABSTRACTAimEpicardial adipose tissue (EAT) may play a role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). We investigated associations of EAT with proteomics, coronary flow reserve (CFR), cardiac structure and function, and quality of life (QoL) in the prospective multinational PROMIS‐HFpEF cohort.Methods and resultsEpicardial adipose tissue was measured by echocardiography in 182 patients and defined as increased if ≥9 mm. Proteins were measured using high‐throughput proximity extension assays. Microvascular dysfunction was evaluated with Doppler‐based CFR, cardiac structural and functional indices with echocardiography and QoL by Kansas City Cardiomyopathy Questionnaire (KCCQ). Patients with increased EAT (n = 54; 30%) had higher body mass index (32 [28–40] vs. 27 [23–30] kg/m2; p < 0.001), lower N‐terminal pro‐B‐type natriuretic peptide (466 [193–1133] vs. 1120 [494–1990] pg/ml; p < 0.001), smaller indexed left ventricular (LV) end‐diastolic and left atrial (LA) volumes and tendency to lower KCCQ score. Non‐indexed LV/LA volumes did not differ between groups. When adjusted for body mass index, EAT remained associated with LV septal wall thickness (coefficient 1.02, 95% confidence interval [CI] 1.00–1.04; p = 0.018) and mitral E wave deceleration time (coefficient 1.03, 95% CI 1.01–1.05; p = 0.005). Increased EAT was associated with proteomic markers of adipose biology and inflammation, insulin resistance, endothelial dysfunction, and dyslipidaemia but not significantly with CFR.ConclusionIncreased EAT was associated with cardiac structural alterations and proteins expressing adiposity, inflammation, lower insulin sensitivity and endothelial dysfunction related to HFpEF pathology, probably driven by general obesity. Potential local mechanical or paracrine effects mediated by EAT remain to be elucidated.
1,2‐Boronate Rearrangement: An Efficient Tool for the Opening, Functionalization and Formation of Strained Cycles
Authors: Blieck Rémi , de la Torre Aurélien 
Published: October 2022

AbstractThe 1,2‐metallate rearrangement occurring with boronate complexes is a strategy of choice for the synthesis of organoboron compounds, giving a direct access to highly functionalized molecules. Lately, significant progress has been made in the use of this reaction for the opening, the functionalization, and the formation of strained cycles. In this review, we will highlight these recent advances, focusing on cycloalkanes and oxygen‐ or nitrogen‐containing strained cycles.
Electrochemical Synthesis of β‐Fluoroselenides
Authors: Wu Shao‐Fen , Yu Yi , Yuan Yaofeng , Li Zhen , Ye Ke‐Yin 
Published: October 2022

AbstractAn environmentally friendly and efficient electrochemical fluoroselenation reaction of olefins has been developed. With the use of commercially available diaryl diselenides, triethylamine trihydrofluoride, and olefins, a diverse array of β‐fluoroselenides could be readily obtained. The reaction conditions are mild, tolerating a wide range of substrates in excellent yields and selectivity, and can be easily extended to gram‐scale preparation of vicinal fluoroselenides, too.
Coupling of N‐Tosylhydrazones with Tetrazoles: A Regioselective Synthesis of 2,5‐Disubstituted‐2H‐Tetrazoles
Authors: Kaszás Tímea , Szakács Bence , Juhász‐Tóth Éva , Cservenyák Ivett , Kovács Tamara , Juhász László , Somsák László , Tóth Marietta 
Published: October 2022

AbstractHerein we describe the C−N coupling reaction of N‐tosylhydrazones with tetrazoles using thermic activation in the presence of different bases. The reactions proved to be highly regioselective to result in the corresponding 2,5‐disubstituted‐2H‐tetrazoles as main products and 1,5‐disubstituted‐1H‐tetrazoles as minor products. Owing to its mild conditions, the method enabled the use of a wide range of substrates.
Response profile in a rat model of exercise‐induced hypoalgesia is associated with duloxetine, pregabalin and diclofenac effect on constriction‐induced neuropathy
Authors: Khan Junad , Wang Qian , Korczeniewska Olga A. , McNeil Rotem , Ren Yanfang , Benoliel Rafael , Eliav Eli 
Published: October 2022

AbstractBackgroundExercise is a known trigger of the inhibitory pain modulation system and its analgesic effect is termed exercise‐induced hypoalgesia (EIH). Previous studies have demonstrated that rats with deficient analgesic response following exercise develop more significant hypersensitivity following nerve injury compared to rats with substantial analgesic response following exercise.ObjectivesA rat model of EIH as an indicator of the pain inhibitory system's efficiency was used to explore the association between EIH profiles and the effect of pharmacotherapy on rat's neuropathic pain.MethodsEIH profiles were assessed by evaluating paw responses to mechanical stimuli before and after exercise on a rotating rod. Rats with a reduction of ≤33% in responses were classified as low EIH and those with ≥67% as high EIH. Low and high EIH rats underwent sciatic nerve chronic constriction injury (CCI). Paw responses to mechanical stimuli were measured at baseline, following CCI, and after treatment with diclofenac, duloxetine or pregabalin. In a different group of low and high EIH rats, EIH was measured before and following treatment with the same medications.ResultsLow EIH rats developed more significant hypersensitivity following CCI. Duloxetine and pregabalin successfully reduced hypersensitivity, although significantly more so in low EIH rats. Diclofenac had limited effects, and only on low EIH rats. Four days of duloxetine administration transformed low EIH rats' profiles to high EIH.ConclusionsThe findings of this study suggest that EIH profiles in rats can not only predict the development of hypersensitivity following injury but may also support targeted pharmacological treatment.SignificanceExercise is a known trigger of the inhibitory pain modulation. Rats with deficient analgesic response following exercise develop more significant hypersensitivity following nerve injury. Pain modulation profiles in rats can also support targeted pharmacological treatment; rats with deficient analgesic response following exercise benefit more from treatment with duloxetine and gabapentin. Treatment with duloxetine can improve pain modulation profile.
Alterations in microglial morphology concentrate in the habitual sleeping period of the mouse
Authors: Steffens Sarah Katharina , Stenberg Tarja Helena , Wigren Henna‐Kaisa Margareta 
Published: October 2022

AbstractIn nocturnal animals, waking appears during the dark period while maximal non‐rapid‐eye‐movement sleep (NREMS) with electroencephalographic slow‐wave‐activity (SWA) takes place at the beginning of the light period. Vigilance states associate with variable levels of neuronal activity: waking with high‐frequency activity patterns while during NREMS, SWA influences neuronal activity in many brain areas. On a glial level, sleep deprivation modifies microglial morphology, but only few studies have investigated microglia through the physiological sleep–wake cycle. To quantify microglial morphology (territory, volume, ramification) throughout the 24 h light–dark cycle, we collected brain samples from inbred C57BL male mice (n = 51) every 3 h and applied a 3D‐reconstruction method for microglial cells on the acquired confocal microscopy images. As microglia express regional heterogeneity and are influenced by local neuronal activity, we chose to investigate three interconnected and functionally well‐characterized brain areas: the somatosensory cortex (SC), the dorsal hippocampus (HC), and the basal forebrain (BF). To temporally associate microglial morphology with vigilance stages, we performed a 24 h polysomnography in a separate group of animals (n = 6). In line with previous findings, microglia displayed de‐ramification in the 12 h light‐ and hyper‐ramification in the 12 h dark period. Notably, we found that the decrease in microglial features was most prominent within the early hours of the light period, co‐occurring with maximal sleep SWA. By the end of the light period, all features reached maximum levels and remained steadily elevated throughout the dark period with minor regional differences. We propose that vigilance‐stage specific neuronal activity, and SWA, could modify microglial morphology.
Biological age calculators to motivate lifestyle change: Environmental scan of online tools and evaluation of behaviour change techniques
Authors: Bonner Carissa , Batcup Carys , Fajardo Michael , Trevena Lyndal 
Published: October 2022

AbstractObjective“Biological age” calculators are widely used as a way of communicating health risk. This study evaluated the behaviour change techniques (BCTs) within such tools, underlying algorithm differences and suitability for people with varying health literacy.MethodsTwo authors entered terms into Google (eg, biological/heart age) and recorded the first 50 results. A standard patient profile was entered into eligible biological age calculators. Evaluation was based on Michie et al's BCT taxonomy and a readability calculator.ResultsFrom 4000 search results, 20 calculators were identified: 11 for cardiovascular age, 7 for general biological age and 2 for fitness age. The calculators gave variable results for the same 65‐year‐old profile: biological age ranged from younger to older (57‐87 years), while heart age was always older (69‐85+ years). Only 11/20 (55%) provided a reference explaining the underlying algorithm. The average reading level was Grade 10 (range 8.7‐12.4; SD 1.44). The most common BCTs were salience of consequences, information about health consequences and credible source.ConclusionsBiological age tools have highly variable results, BCTs and readability.Practice ImplicationsDevelopers are advised to use validated models, explain the result at the average Grade 8 reading level, and incorporate a clear call to action using evidence‐based behaviour change techniques.