bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Urban and Rural Limitation Health Services Pregnant Mother’s on the Pandemic Covid-19, Papua Province of Indonesia
Authors: Irab Semuel Piter , Makaba Sarce , Irmanto Maxsi , Bella Sarni R. , Irjayanti Apriyana , Rumaropen Nova F. , Rumbiak Helmin R. 
Published: April 2022

Coronavirus disease-19 (Covid-19), has become a pandemic and spread very quickly, reaching Indonesia and Papua Province. Impact covid-19, apparently influenced public health services, especially in a woman. A cross-sectional study design, to describe differences limitations in the pregnant mother's health services urban and rural. Jayapura City and Jayapura Regency research sites. The sample was 90 pregnant mothers living in urban areas, and 90 pregnant mothers living in rural areas. Data analysis using Paired samples t-test. There were differences between urban and rural pandemics covid-19 (p-value = 0.020), there are limitations post integrated services health of the urban and rural (p-value = 0.049), community health centers urban and rural(p-value = 0.026), hospital health services urban and rural (p-value = 0.041), doctor/midwife health practices urban and rural (p-value = 0.019), antenatal care urban and rural (p-value = 0.000), and health services sick pregnant mothers for urban and rural (p-value = 0,000). Confirmation of covid-19 patients has increased, community compliance with implementing health protocols is low, it is increasingly difficult to break the chain of coronavirus transmission in the community, and health service units are limited to pregnant women in Papua Province.
Revisiting regional variation in the age‐related reduction in sweat rate during passive heat stress
Authors: Schmidt Madison D. , Notley Sean R. , Meade Robert D. , Akerman Ashley P. , Rutherford Maura M. , Kenny Glen P. 
Published: April 2022

AbstractAging is associated with attenuated sweat gland function, which has been suggested to occur in a peripheral‐to‐central manner. However, evidence supporting this hypothesis remains equivocal. We revisited this hypothesis by evaluating the sweat rate across the limbs and trunk in young and older men during whole‐body, passive heating. A water‐perfused suit was used to raise and clamp esophageal temperature at 0.6°C (low‐heat strain) and 1.2°C (moderate‐heat strain) above baseline in 14 young (24 (SD 5) years) and 15 older (69 (4) years) men. Sweat rate was measured at multiple sites on the trunk (chest, abdomen) and limbs (biceps, forearm, quadriceps, calf) using ventilated capsules (3.8 cm2). Sweat rates, expressed as the average of 5 min of stable sweating at low‐ and moderate‐heat strain, were compared between groups (young, older) and regions (trunk, limbs) within each level of heat strain using a linear mixed‐effects model with nested intercepts (sites nested within region nested within participant). At low‐heat strain, the age‐related reduction in sweat rate (older‐young values) was greater at the trunk (0.65 mg/cm2/min [95% CI 0.44, 0.86]) compared to the limbs (0.42 mg/cm2/min [0.22, 0.62]; interaction:p = 0.010). At moderate‐heat strain, sweat rate was lower in older compared to young (main effect:p = 0.025), albeit that reduction did not differ between regions (interaction:p = 0.888). We conclude that, contrary to previous suggestions, the age‐related decline in sweat rate was greater at the trunk compared to the limbs at low‐heat strain, with no evidence of regional variation in that age‐related decline at moderate‐heat strain.
Reception of the Lord’s Prayer in Pentecostal-Charismatic Christianity in Ghana
Authors: Wandusim Michael F. 
Published: April 2022

AbstractThe liturgical reception of the Lord’s Prayer (Matt 6:9–13 par. Luke 11:2 b–4) is well-attested and still evident in Catholic, Protestant and Orthodox circles. For instance, in reformed worship it is usual to hear varied versions of the statement: “And now as our saviour Christ has taught us, we humbly pray: ‘Our Father who art in heaven (…)’.” It is striking, however, that such a liturgical use of the text is scarce in Pentecostal-Charismatic Christian worship. Such is the case in Ghana, where Pentecostal-Charismatic Christianity forms the largest and most popular stream of the tradition. It only takes a visit to a Ghanaian Pentecostal-Charismatic church during a worship session to ascertain this fact. This article investigates this liturgical phenomenon in Pentecostal-Charismatic worship by analyzing a selection of popular literature written on the text of the Lord’s Prayer and through personal interviews with some of the leaders of Pentecostal-Charismatic churches. Before engaging in reception analysis, a brief exegetical study of the text is undertaken. The article concludes that the Lord’s Prayer does not appear in Pentecostal-Charismatic liturgy because it does not conform with the Pentecostal-Charismatic understanding of prayer. Instead it is conceived of as a pattern or model and hence chiefly employed as a means of instruction on effective prayer rather than for recitation each Sunday, as manifest in Protestant, Catholic, and Orthodox circles.
Effects of localized environment on the eucalypt clones quality aiming kraft pulp production
Authors: Corradi Isadora Silva , Borges Gomes Fernando José , Borges Felipe Pedersoli , Nogueira Thales Augusto Pinto Coelho 
Published: April 2022

Abstract
Wood is the most expensive fraction in the pulp production costs. Therefore, strategies for increasing wood quality such as faster growth, higher wood basic density and lower lignin content are drivers to pulp mills. The cultivation site as well as the eucalypt clones influence the wood quality, which, in turn, affects the pulp production performance. Thus, this work aims to evaluate the effect of the site on the wood quality for the pulp production. Three eucalypt clones from five different sites in Brazil were used in this study. These samples were selected aiming to represent a gradient of environmental stress. It was possible to observe a reduction in the content of extractives and lignin and an increase in the content of glucans in the sites with less environmental stress, reflecting in the production of pulp with less effective alkali demanded (reduction of 13.5 %) and an increase of 10.5 % in the kraft pulp screened yield. MAIP values of 22.7 ton/ha/year were obtained in the sites with less environmental stress, presenting a lower specific wood consumption. Through the production indicators, it was observed that the C1 clone is more adaptable to the regions of greater environmental stress than the other clones analyzed.
Gut dysbiosis and homocysteine: a couple for boosting neurotoxicity in Huntington disease
Authors: Martínez-Lazcano Juan Carlos , González-Guevara Edith , Boll Catherine , Cárdenas Graciela 
Published: April 2022

Abstract
Huntington’s disease (HD), a neurodegenerative disorder caused by an expansion of the huntingtin triplet (Htt), is clinically characterized by cognitive and neuropsychiatric alterations. Although these alterations appear to be related to mutant Htt (mHtt)-induced neurotoxicity, several other factors are involved. The gut microbiota is a known modulator of brain-gut communication and when altered (dysbiosis), several complaints can be developed including gastrointestinal dysfunction which may have a negative impact on cognition, behavior, and other mental functions in HD through several mechanisms, including increased levels of lipopolysaccharide, proinflammatory cytokines and immune cell response, as well as alterations in Ca2+ signaling, resulting in both increased intestinal and blood-brain barrier (BBB) permeability. Recently, the presence of dysbiosis has been described in both transgenic mouse models and HD patients. A bidirectional influence between host brain tissues and the gut microbiota has been observed. On the one hand, the host diet influences the composition and function of microbiota; and on the other hand, microbiota products can affect BBB permeability, synaptogenesis, and the regulation of neurotransmitters and neurotrophic factors, which has a direct effect on host metabolism and brain function. This review summarizes the available evidence on the pathogenic synergism of dysbiosis and homocysteine, and their role in the transgression of BBB integrity and their potential neurotoxicity of HD.
Structural, Hirshfeld Surface and HOMO-LUMO gap analysis of five co-crystals of 2-amino-5-chloropyridine or 2-amino-bromopyridine with isomeric methylbenzoic acids
Authors: Rosli Mohd Mustaqim , Khalib Nuridayanti Che , Thanigaimani Kaliyaperumal , Arshad Suhana , Razak Ibrahim Abdul 
Published: April 2022

Abstract
The 1:1 co-crystals formed between 2-amino-5-chloropyridine/2-amino-5-bromopyridine and isomeric n-methyl-benzoic acids [n = 2, 3 and 4] are described. The co-crystals with the n = 2 co-former are isostructural. The co-formers are linked by intermolecular hydrogen bonds involving amino-N–H⋯O(carbonyl) and hydroxyl-O–H⋯N(pyridine). Additional and comparable amino-N–H⋯O(carbonyl) hydrogen bonds were evident in all co-crystals and play an important role in stabilising the molecular packing. The intermolecular interactions were also analysed through the calculated Hirshfeld surfaces. The charge transfer occurring between the calculated HOMO-LUMO states suggests electron mobility within the co-crystals owing to the aforementioned hydrogen bonding.
Strength and Conditioning Considerations for Kyokushin Karate Athletes
Authors: Navickaitė Austėja , Thomas Gavin 
Published: April 2022

ABSTRACT
Strength and conditioning (S&C) are a key part of athletic preparation; however, kyokushin karate is an under researched area, and there is a lack of specific training recommendations for its athletes. The aims of this article were to (a) review the demands of kyokushin karate through conducting a needs analysis, (b) recommend a battery of fitness tests, and (c) provide training recommendations for kyokushin karatekas. This article synthesizes research on kyokushin karatekas and associated combat sports to produce practical applications that can be put to immediate use within the field of S&C.
Types of Rats and Their Parasites That Potential to Transmit Disease in Tugu District, Semarang City
Authors: Setiati Ning , Auliya Rusyda , Partaya Partaya , Bodijantoro F. Putut Martin Herry , Indriyanti Dyah Rini , Widiyaningrum Priyantini 
Published: April 2022

Rats are known as vectors and reservoirs for various types of ecto and endoparasites. The existence of rats as cosmopolitan animals allows for complex parasitic transmission due to the relationship between humans, animals, and the environment. This study aimed to provide informative data on the types of rat along with their ecto- and endoparasites. This research is a qualitative descriptive study. Data collection was carried out by random sampling survey with a point time approach. Data collection was carried out in 4 villages, namely Tugurejo, Mangkang Wetan, Mangunharjo, and Mangkang Kulon Villages, Tugu District, Semarang City. A total of 89 rats were obtained, the species obtained were R. norvegicus, R. argentiventer, R. exulans, R. tiomanicus, R. surifer, R. tanezumi, B indica, and S. murinus. Ectoparasite infestation was found in all types of rats except S. murinus. The ectoparasites found were Xenopsylla cheopis and Laelaps echidninus which were reported as the main vectors of murine typhus, epidemic typhus, bartonellosis as well as scrub typhus and Q-fever disease. Endoparasite infestation was found in the intestinal organs, namely Diphyllobothrium sp. and two species of worm eggs Hymnoepis sp. and Trichuris trichiura which were reported as the cause of Diphyllobothriasis as well as digestion, absorption, which can result in the loss of protein, carbohydrates, fats, and blood in large quantities. Diphyllobothriasis is not transmitted from person to person, more than one family member can be infected by sharing common meals and having similar eating habits. This study can be used as an early warning for community against the potential of infectious diseases from rats as vectors in Tugu District, Semarang related to rats density, endoparasites and their ectoparasites.
L’environnement naturel abiotique dans le conte Comment Le Désert A Disparu par Isabelle Hoarau
Authors: Mulyani Sri , Lustyantie Ninuk , Savitri Dian 
Published: April 2022

Abstract
L'environnement naturel abiotique dans le conte Comment le désert a disparu par Isabelle Hoarau. L’objectif de cette recherche est d’analyser, de trouver, et de décrire l'environnement naturel abiotique, les données sont issues des mots ou des phrases du conte Comment le désert a disparu par Isabelle Hoarau. L’approche utilisée est une approche qualitative de l’étude écologie littéraire utulisant la méthode d’analyse de contenu. La procédure de recherche commence par les données sont lues et comprises en premier. De plus, les données analysées se réfèrent à la théorie de l'environnement naturel abiotique. Le résultat de cette recherche rèvele qu’il existe 13 données contenant l'environnement naturel abiotique. Les facteurs de l’environnement naturel abiotique les plus abondants sont l'eau (4 données), le sol (3 données), le climat (3 données), le soleil (2 données) et puis l'air (1 donnée). Donc, on peut conclure dans le conte Comment le désert a disparu que l’environnement naturel abiotique a un rôle important dans la survie de tous les organismes sur terre.
Abstract
The Abiotic Natural Environment in Fairy Tale Comment le désert a disparu by Isabelle Hoarau. The purpose of this research is to analyze, find, and describe the abiotic natural environment, the data come obtained from the words or sentences of the tale Comment le désert a disparu par Isabelle Hoarau. The approach used is a qualitative approach using the content analysis method of literature ecology studies. The research procedure begins with the data must be read and understood before analysis process. Furthermore, the data is analyzed referring to the theory of abiotic natural environment. The results of this study indicate that there are 13 data containing the abiotic natural environment. The most abundant abiotic natural environment are water (4 data), then soil (3 data), climate (3 data), followed by the sun (2 data) and air (1 data). Thus, we can conclude in the fairy tale Comment le désert a disparu that the abiotic natural environment has an important role in the survival of all organisms on earth.
Surrogate markers in non-alcoholic steatohepatitis
Authors: Ismaiel Abdulrahman , Dumitrascu Dan L. 
Published: April 2022

Background. Hepatic steatosis with inflammation, inflated hepatocytes, and potential fibrosis defines non-alcoholic steatohepatitis (NASH), which can possibly lead to liver cirrhosis. Although liver biopsy is still the gold standard for diagnosing NASH, numerous non-invasive surrogate markers have been investigated to reduce the need for this invasive technique. In this review we present several currently assessed biomarkers, scores, and indexes in assessing NASH Methods. A search in the main medical literature databases was conducted. We searched for observational studies evaluating non-invasive markers, scores, and panels in predicting NASH.
Results. Several proinflammatory markers, inflammation and apoptosis biomarkers, as well as complex models have been studied in predicting NASH. Proinflammatory markers include C-reactive protein, ferritin, tumor necrosis factor-α, interleukin-6, pentraxin-3, and neutrophil extracellular traps. Inflammation and apoptosis biomarkers include cytokineratin-18, adipocytokines, lipid oxidation panels, plasminogen activator inhibitor-1, and products of free radical-mediated oxidation of linoleic acid. Moreover, several studied complex models such as NashTest, NashTest-2, pairing CK18 fragments with other biomarkers such as ALT and the presence of MetS, the HAIR model, acNASH, NAFIC score, Visceral Adiposity Index have also been studied.
Conclusion. A variety of diagnostic panels have shown good predictive values for diagnosing NASH. Nevertheless, non-invasive surrogate markers are currently unable to replace liver biopsy. However, their clinical significance is mainly in triaging patients for liver biopsy, reducing the financial burden associated with the procedure.
GENITAL WARTS INCIDENCE IN SAINT-PETERBURG, LENINGRADSKAYA REGION, KARELIYA REPUBLIC IN 2004–2013
Authors: Stebelko O. Yu. , Gayvoronskaya O. V. , Kasatkin E. V. , Katkyavichene E. V. , Egorova Yu. S. 
Published: April 2022

Abstract. In 2012, information on vaccination against human papillomavirus infection was included in the form of state statistics number 5 «Information on vaccinations» in according to the Order of Rosstat number 645. In the world practice, as one of the early performance criteria of effectiveness of immunization against human papilloma virus is morbidity rate by anogenital warts. The aim of this study was to investigate the regional characteristics of distribution of anogenital (venereal) warts before and in the initial periods of vaccination against human papillomavirus infection in three regions of the North-West Federal Regions — Saint Petersburg, Leningrad Oblast, Republic of Karelia. The period of retrospective epidemiological analysis was 10 years. There were significant differences in the levels and trends, morbidity by anogenital warts in general population and by gender. Moreover, different patterns of the frequency of disease among household contacts were revealed. In all three areas persons of 18–29 years old were identified as the risk group. The importance of determining the characteristics of epidemic processes for specified nosology in each territory has been demonstrated.
Capsanthin-Loaded Micelles: Preparation, Characterization and in vitro Evaluation of Cytotoxicity Using MDA-MB-231 Breast Cancer Cell Line
Authors: Shanmugham Velmurugan , Subban Ravi 
Published: April 2022

Research background. Breast cancer is one of the most common cancers and remains a major cause of morbidity and mortality among women worldwide. In developed countries, breast cancer as a multifactorial disease is a major health concern, and its incidence is constantly rising in low and middle-income countries. Numerous studies have demonstrated that phytochemicals such as carotenoids inhibit breast cancer growth and induce apoptosis. We recently enhanced the solubility of capsanthin in water by encapsulating it in diosgenin polyethylene glycol succinate, a novel non-ionic surfactant. Thus, this study aims to evaluate the cytotoxicity of water-soluble capsanthin-loaded micelles in MDA-MB-231 cells in vitro through tetrazolium dye MTT assay.
Experimental approach. In the current study, capsanthin, a hydrophobic carotenoid, is extracted from sweet red pepper (Capsicum annuum). Capsanthin-loaded diosgenin polyethylene glycol succinate 1000 (cap-DPGS-1000) micelles were prepared from capsanthin extract (cap) and diosgenin polyethylene glycol succinate 1000 (DPGS-1000) using the solid dispersion method. The capsanthin extract and cap-DPGS-1000 micelles were characterized by UV-visible spectroscopy, high-performance liquid chromatography (HPLC), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), particle size distribution, polydispersity, and scanning electron microscopy (SEM). The effects of capsanthin extract and cap-DPGS-1000 micelles on a human triple-negative breast cancer cell line (MDA-MB-231) were tested to check the cell viability, proliferation and cytotoxicity of the micelles.
Results and conclusions. The solubility of encapsulated cap-DPGS-1000 micelles in water is greatly enhanced and leads to an increased scope for localized drug delivery, a better delivery option for treating residual cancerous tumours. The encapsulated capsanthin showed a sustained release in simulated intestinal fluid (pH=6.8). Our research proposes a sustained drug delivery system that ensures effective and controlled release to the affected site. The characterization data revealed no change in the structure and functional groups in the encapsulated capsanthin. The IC50 value of the cap-DPGS-1000 micelles against MDA-MB-231 breast cancer cells was (3.10±1.09) μg/mL, which is much lower than of capsanthin extract ((81.1±1.5) μg/mL). Capsanthin extract and capsanthin-loaded micelles are promising drug candidates to induce apoptosis and increase reactive oxygen species (ROS) in cancer cells.
Novelty and scientific contribution. The result shows the cytotoxic effect of capsanthin and capsanthin-loaded micelles on MDA-MB-231 cell line for the first time. Capsanthin from sweet red pepper (Capsicum annuum) showed remarkable cytotoxic effect on the triple-negative MDA-MB-231 cell line.
Conceptual Approaches to the Organization of Prosecutorial Activities in the Fight Against Global Corruption
Authors: Kakitelashvili Mikhail M. 
Published: April 2022

On the basis of analysis of international acts, national legislation, and law enforcement practice, the article shows the conceptual approaches in the organization and activities of prosecutorial authorities in the fight against corruption. This article aims to determine optimal ways to improve the legal status of the prosecutors office to improve its effectiveness against corruption.
The objectives of the study are to identify international principles in the organization of international anti-corruption bodies; to identify the problems of organization in the activities of specialized anti-corruption prosecution services; to determine the main directions of prosecutorial activities in the fight against corruption; to identify the role of international cooperation of prosecutors in the fight against corruption.
The object of the study were public relations formed in the process of the prosecutors office in the fight against corruption, and the subject the rules of law governing the activities of prosecutorial authorities and the practice of their application.
The methodology of research is general scientific methods of knowledge (dialectical, analysis and synthesis, modeling, and so on).
The article contains a comparative legal analysis of the legislation of foreign countries regulating the activities of prosecutors in the fight against corruption. Particular attention is paid to the organization and activities of prosecutorial authorities of CIS countries. Proceeding from the specifics of organization and activity, prosecutorial authorities of foreign countries are endowed with different volumes of powers in combating corruption. The engagement of prosecution authorities worldwide in combating corruption has led to the creation of specialized units within their structure. In many countries, however, an inter-agency opposition exists between specialized anti-corruption bodies and prosecutors offices due to overlapping responsibilities.
The prosecution authorities of Belarus, Russia, Kazakhstan, Uzbekistan, Tajikistan, and other countries have the greatest powers in the criminal and non-criminal spheres. Prosecutors offices in these countries are empowered to supervise the implementation of anti-corruption legislation and coordinate anti-corruption activities of the entire law enforcement system. A promising direction to improve the effectiveness of prosecution is the introduction of SWOT-analysis in its activities. Moreover, based on interstate training centers, a need for the advanced training of prosecutors persists. Considering the positive experience of creating the European Public Prosecutors Office, the expediency of granting the Coordinating Council of Prosecutors General of the CIS countries with additional powers to coordinate the activities of prosecution authorities in the fight against corruption was substantiated.