bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct Electrodeposition of Bimetallic Nanostructures on Co-Based MOFs for Electrochemical Sensing of Hydrogen Peroxide
Authors: Xie Yixuan , Shi Xianhua , Chen Linxi , Lu Jing , Lu Xiange , Sun Duanping , Zhang Luyong 
Published: March 2022

Hydrogen peroxide (H2O2) is the most significant reactive oxygen species in biological systems. Here, we reported an electrochemical sensor for the detection of H2O2 on the basis of bimetallic gold-platinum nanoparticles (Au3Pt7 NPs) supported by Co-based metal organic frameworks (Co-MOFs). First, Au3Pt7 NPs, with optimal electrocatalytic activity and accessible active surface, can be deposited on the surface of the Co-MOF–modified glassy carbon electrodes (Au3Pt7/Co-MOFs/GCE) by one-step electrodeposition method. Then, the electrochemical results demonstrated that the two-dimensional (2D) Co-MOF nanosheets as the supporting material displayed better electrocatalytic properties than the 3D Co-MOF crystals for reduction of H2O2. The fabricated Au3Pt7/2D Co-MOF exhibited high electrocatalytic activity, and the catalytic current was linear with H2O2 concentration from 0.1 μM to 5 mM, and 5–60 mM with a low detection limit of 0.02 μM (S/N = 3). The remarkable electroanalytical performance of Au3Pt7/2D Co-MOF can be attributed to the synergistic effect of the high dispersion of the Au3Pt7 NPs with the marvelous electrochemical properties and the 2D Co-MOF with high-specific surface areas. Furthermore, this sensor has been utilized to detect H2O2 concentrations released from the human Hela cells. This work provides a new method for improving the performance of electrochemical sensors by choosing the proper support materials from diverse crystal morphology materials.
Indirect Transfer to Catheterization Laboratory for ST Elevation Myocardial Infarction Is Associated With Mortality Independent of System Delays: Insights From the France-PCI Registry
Authors: Beygui Farzin , Roule Vincent , Ivanes Fabrice , Dechery Thierry , Bizeau Olivier , Roussel Laurent , Dequenne Philippe , Arnould Marc-Antoine , Combaret Nicolas , Collet Jean Philippe , Commeau Philippe , Cayla Guillaume , Montalescot Gilles , Benamer Hakim , Motreff Pascal , Angoulvant Denis , Marcollet Pierre , Chassaing Stephan , Blanchart Katrien , Koning René , Rangé Grégoire 
Published: March 2022

BackgroundFirst medical contact (FMC)-to-balloon time is associated with outcome of ST-elevation myocardial infarction (STEMI). We assessed the impact on mortality and the determinants of indirect vs. direct transfer to the cardiac catheterization laboratory (CCL).MethodsWe analyzed data from 2,206 STEMI patients consecutively included in a prospective multiregional percutaneous coronary intervention (PCI) registry. The primary endpoint was 1-year mortality. The impact of indirect admission to CCL on mortality was assessed using Cox models adjusted on FMC-to-balloon time and covariables unequally distributed between groups. A multivariable logistic regression model assessed determinants of indirect transfer.ResultsA total of 359 (16.3%) and 1847 (83.7%) were indirectly and directly admitted for PCI. Indirect admission was associated with higher risk features, different FMCs and suboptimal pre-PCI antithrombotic therapy.At 1-year follow-up, 51 (14.6%) and 137 (7.7%) were dead in the indirect and direct admission groups, respectively (adjusted-HR 1.73; 95% CI 1.22–2.45). The association of indirect admission with mortality was independent of pre-FMC and FMC characteristics. Older age, paramedics- and private physician-FMCs were independent determinants of indirect admission (adjusted-HRs 1.02 per year, 95% CI 1.003–1.03; 5.94, 95% CI 5.94 3.89–9.01; 3.41; 95% CI 1.86–6.2, respectively).ConclusionsOur study showed that, indirect admission to PCI for STEMI is associated with 1-year mortality independent of FMC to balloon time and should be considered as an indicator of quality of care. Indirect admission is associated with higher-risk features and suboptimal antithrombotic therapy. Older age, paramedics-FMC and self-presentation to a private physician were independently associated with indirect admission. Our study, supports population education especially targeting elderly, more adequately dispatched FMC and improved pre-CCL management.
Low Birth Weight, β-Cell Function and Insulin Resistance in Adults: The Brazilian Longitudinal Study of Adult Health
Authors: Branda Julia Ines F. , de Almeida-Pititto Bianca , Bensenor Isabela , Lotufo Paulo A. , Ferreira Sandra Roberta G. 
Published: March 2022

BackgroundAdverse intrauterine environment—reflected by low birth weight (LBW)—has been linked to insulin resistance and type 2 diabetes later in life. Whether β-cell function reduction and insulin resistance could be detected even in middle-aged adults without overt diabetes is less investigated. We examined the association of LBW with β-cell function and insulin sensitivity in non-diabetic middle-aged adults from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).MethodsThis is a cross-sectional analysis of 2,634 ELSA-Brasil participants aged between 34 and 59 years, without diabetes. Participants were stratified according to LBW defined as &lt;2.5 kg and their clinical data were compared. HOMA-IR, HOMA-β, HOMA-adiponectin, TyG index, QUICKI and TG/HDL were calculated and their association with LBW were tested using multiple linear regression including adjustments suggested by Directed Acyclic Graphs and propensity score matching was applied.ResultsThe sample (47.4 ± 6.3 years) was composed of 57.5% of women and 9% had LBW. Subjects with LBW and normal-weight reported similar BMI values at the age of 20 years and current BMI was slightly lower in the LBW group. In average, cardiometabolic risk profile and also indexes of β-cell function and insulin sensitivity were within normal ranges. In regression analysis, log-transformed HOMA-β—but not with the other indexes—was associated with LBW (p = 0.014) independent of sex, skin color, prematurity, and family history of diabetes. After applying propensity-score matching in a well-balanced sample, HOMA-AD and TG/HDL indexes were associated with LBW.ConclusionThe association between LBW and insulin sensitivity markers may occur in healthy middle-aged adults before overt glucose metabolism disturbances. Our data are coherent with the detection of early life events consequent with insulin resistance markers that could contribute to the risk of glucose metabolism disturbances.
Casual Associations and Shape Between Prepuberty Body Mass Index and Early Onset of Puberty: A Mendelian Randomization and Dose–Response Relationship Analysis
Authors: Fang Jiao , Yuan Jingyi , Zhang Dandan , Liu Wanxu , Su Puyu , Wan Yuhui , Zhang Zhihua , Tao Fangbiao , Sun Ying 
Published: March 2022

BackgroundThere is an ongoing controversial issue regarding whether onset of puberty is related to childhood BMI.ObjectivesThis study aims at investigating the causal association and its shape between prepuberty BMI and early puberty onset.MethodsBreast development and testicular volume were assessed annually from a population-based prospective cohort of 997 children for consecutive years by professional endocrinologists. Seventeen puberty- and BMI-related SNPs were selected to calculate the polygenic risk score. The two-stage least square method was used to assess and confirm causal effects. A dose–response association between prepuberty BMI and early puberty onset was conducted by using restricted cubic spline Cox regression.ResultsAfter adjusting for covariates, prepuberty BMI was positively associated with early thelarche among girls (coefficients = 0.18, 95% CI: 0.01, 0.29). A non-linear model suggested an inverted U-shaped relationship between prepuberty BMI and risk for early thelarche (χ2 = 276.3, p &lt; 0.001). The risk for early thelarche increased rapidly from prepuberty BMI at 15.70 kg/m2 (P25) to 20.75 kg/m2 (P85) and gradually decreased afterward. Compared with the P25 of prepuberty BMI, the HRs (95% CI) for early thelarche were 5.08 (1.15, 8.55), 4.48 (1.02, 7.74), 10.15 (3.93, 17.50), and 8.43 (1.91, 13.71) for percentiles P25–P50, P50–P75, P75–P85, and ≥P85 of BMI categories, respectively. In boys, compared with the P25 of prepuberty BMI, boys with BMI between P25 and P50 showed an increased risk of early puberty (HR: 3.94, 95% CI: 1.44, 6.80).ConclusionsPrepuberty BMI may serve the purpose of identifying the girls at higher risk of early thelarche, which could assist in the adaptation of prevention and intervention strategies targeting childhood obesity. The findings emphasize a non-linear correlation between prepuberty BMI and early puberty onset.
Practical Challenges in Hybrid Communication Ecosystems Based on ITS-G5 and LTE for CACC and GLOSA
Authors: Cimoli Bruno , Xing Haitao , Ho Victor , Passchier Igor , Kakes Geerd , Rommel Simon , Nijmeijer Henk , Tafur Monroy Idelfonso 
Published: March 2022

In this paper we report the implementation and experimental evaluation of a proposed hybrid communication ecosystem for CCAM applications such as cooperative adaptive cruise control (CACC) and smart intersections. Three wireless technologies have been suggested for communications between vehicles and intelligent traffic lights and are evaluated in this work: ITS-G5 based on IEEE 802.11p and LTE sidelink with PC5 air interface for direct short range links, and regular mobile LTE with LTE Uu air interface for long range or indirect links. The applications used are independent of the communication channel, to enable a comparison on the application level of the different communication technologies. Field experiments were carried out with two CACC-equipped vehicles and three intelligent traffic lights in two field test locations under ideal, i.e., no-traffic, conditions and with real traffic. Experimental results related to CACC show that the best performance in terms of latency is achieved by the ITS-G5 system, while LTE PC5 and LTE Uu links show a penalty of 20 and 50 ms respectively. However, experimental results show that all three communication technologies were still able to guarantee string stable performance of the vehicle platoon. Regarding the smart intersections, an analysis based on field measurements and comparison between long- and short-range solutions is proposed; the analysis includes the impact of each channel on the applications such as speed advisory and green light prediction. The reported experimental evaluation shows the potential of current mobile technologies for CCAM use cases and highlights the way for further CCAM applications based on 5G and beyond mobile networks.
Cell-Based NIPT Detects 47,XXY Genotype in a Twin Pregnancy
Authors: Jeppesen Line Dahl , Hjortshøj Tina Duelund , Hindkjær Johnny , Hatt Lotte , Petersen Olav Bjørn , Singh Ripudaman , Schelde Palle , Andreasen Lotte , Christensen Rikke , Lildballe Dorte L. , Vogel Ida 
Published: March 2022

Background: The existing risk of procedure-related miscarriage following invasive sampling for prenatal diagnosis is higher for twin pregnancies and some women are reluctant to test these typically difficultly obtained pregnancies invasively. Therefore, there is a need for noninvasive testing options that can test twin pregnancies at an early gestational age and ideally test the twins individually.Case presentation: A pregnant woman opted for cell-based NIPT at GA 10 + 5. As cell-based NIPT is not established for use in twins, the test was provided in a research setting only, when an ultrasound scan showed that she carried dichorionic twins.Materials and Methods: Fifty mL of peripheral blood was sampled, and circulating fetal cells were enriched and isolated. Individual cells were subject to whole-genome amplification and STR analysis. Three fetal cells were analyzed by chromosomal microarray (aCGH).Results: We identified 20 fetal cells all sharing the same genetic profile, which increased the likelihood of monozygotic twins. aCGH of three fetal cells showed the presence of two X chromosomes and a gain of chromosome Y. CVS from both placentae confirmed the sex chromosomal anomaly, 47,XXY and that both fetuses were affected.Conclusion: NIPT options can provide valuable genetic information to twin pregnancies that help the couples in their decision-making on prenatal testing. Little has been published about the use of cell-based NIPT in twin pregnancies, but the method may offer the possibility to obtain individual cell-based NIPT results in dizygotic twins.
Hall Effect Study of the Metamagnetic Transition in the Sr4(Ru0.99Fe0.01)3O10 Nanosheet
Authors: Wan Jiajie , Liu Yan , Wan Yuanqing , Wu Qing , Wang Yu , Yang Jiyong , Mao Zhiqiang , Wang Junzhong 
Published: March 2022

Sr4(Ru0.99Fe0.01)3O10 shows a ferromagnetic (FM) transition at TC ∼ 105 K with the magnetic easy axis in the ab plane, followed by a metamagnetic transition (MMT) at low temperatures when the magnetic field H is applied along the c axis, which is in sharp contrast to that of the pure Sr4Ru3O10, where the easy axis is along the c axis and the MMT is in the ab plane. Here, we studied the MMT in the Sr4(Ru0.99Fe0.01)3O10 nanosheet by the Hall effect. It was found that the ordinary Hall coefficient of Sr4(Ru0.99Fe0.01)3O10 is almost the same as that of the pure Sr4Ru3O10, while a sudden increase in the Hall resistance Rxy is observed below ∼50 K, above which the Rxy presents the conventional anomalous Hall effect up to TC. Analysis of the results indicates that the MMT has no direct correlation to the electronic structure but closely relates to the magnetic moment locking, where the magnetic-field-induced breakdown of the locked moments is responsible for the MMT.
Air Trapping and the Risk of COPD Exacerbation: Analysis From Prospective KOCOSS Cohort
Authors: Kim Youlim , Kim Sang Hyuk , Rhee Chin Kook , Lee Jae Seung , Lee Chang Youl , Kim Deog Kyeom , Shin Kyeong-Cheol , Jung Ki Suck , Yoo Kwang Ha , Park Yong Bum 
Published: March 2022

Background and AimsAir trapping is a predictive index for a decline in lung function and mortality in patients with chronic obstructive pulmonary disease (COPD). However, the role of air trapping in COPD exacerbation has rarely been studied. Therefore, this study aimed to investigate the impact of air trapping as a continuous parameter on COPD exacerbation.Materials and MethodsTo evaluate air trapping, we identified the ratio of residual volume (RV) to total lung capacity (TLC) of patients with COPD from the Korean COPD Subgroup Study (KOCOSS) cohort, which is a multicenter-based, prospective, consecutive cohort in Korea. The primary outcome was a development of COPD exacerbation during 3 years of follow-up.ResultsOf 2,181 participants, 902 patients measured the RV/TLC ratio in the baseline enrollment, and 410 were evaluated for assessing the development of COPD exacerbation. Of 410 patients, the rate of moderate to severe exacerbation and severe exacerbation was 70.7% and 25.9%. A 10% increase of RV/TLC ratio increased the risk of the moderate to severe exacerbation by 35% and severe exacerbation by 36%. In subgroup analysis, an interaction effect between triple inhaled therapy and the RV/TLC ratio for severe exacerbation nullified the association between the RV/TLC ratio and severe exacerbation (p for interaction = 0.002).ConclusionsIn this prospective cohort study, we found that air trapping (representing RV/TLC ratio as a continuous parameter) showed an association with an increased risk of COPD exacerbation, particularly in patients who have not undergone triple inhaler therapy.
Factors Contributing to Malnutrition in Parkinson's Disease Patients With Freezing of Gait
Authors: Zhang Li-Li , Zhang Liang , Dong Jingde , Zhao Ying , Wang Xiao-Ping 
Published: March 2022

Background and PurposeLittle is known about the nutritional status and clinical characteristics of patients with Parkinson's disease with freezing of gait (PDFOG). The purpose of this study was to describe the relationship between nutritional status and characteristics of patients with PDFOG.MethodsIn this cross-sectional study, 178 PDFOG patients were recruited and classified as nutritionally normal or at risk of malnutrition/already malnourished based on their Mini Nutritional Assessment (MNA) scores. Each participant underwent a structured questionnaire, physical examination and routine serum biochemical tests.ResultsWe found that 44.4 and 37.1% of PDFOG patients were malnourished [mini nutritional assessment (MNA) score &lt;17] and at risk of malnutrition (17 ≤ MNA score ≤ 23.5), respectively. Compared to patients with normal nutrition, PDFOG patients with malnutrition and at risk of malnutrition had longer duration of Parkinson's disease (PD) and freezing of gait (FOG), more levodopa equivalent daily doses (LEDD), lower body mass index (BMI), more motor symptoms according to the Unified PD Rating Scale-III (UPDRS-III) and non-motor symptoms according to the PD Non-motor Symptoms Questionnaire (PD-NMS) (P &lt; 0.05). Uric acid, albumin, prealbumin, and total cholesterol (TC) differed between the two groups (P &lt; 0.05). High Hoehn and Yahr (H-Y) stage, high Freezing of Gait Questionnaire (FOGQ) scores, low TC and low uric acid were risk factors for malnutrition in patients with PDFOG.ConclusionOur results showed disease severity, motor symptoms, TC levels and uric acid levels were all associated with nutritional status in patients with PDFOG. This study suggest early discovery of the nutritional status of PDFOG patients is important.
Camrelizumab Combined With Gemcitabine and Albumin-Bound Paclitaxel for Neoadjuvant Therapy in the Treatment of Progressive Gallbladder Cancer: A Case Report
Authors: Wu Jing , Wang Zheng , Li Jing , Peng Xue-Hui , Tang Yi-Chen , Huang Xiao-Bing , He Yong-Gang 
Published: March 2022

BackgroundThe roles of immune checkpoint inhibitors in the treatment of gallbladder cancer are still unclear and challenged by controversial findings. Recent research has shown that immune checkpoint inhibitors in combination with chemotherapy may alleviate disease progression.Case SummaryA 45-year-old female patient with gallbladder cancer accompanied by multiple abdominal lymph node metastasis was treated with camrelizumab combined with paclitaxel for injection (albumin-bound) and gemcitabine (AG) to downstage the tumor before a radical surgery could be performed. The postoperative quality of life was superior to the preoperative level.ConclusionCamrelizumab + AG offers a new therapeutic option for gallbladder cancer with multiple abdominal lymph node metastasis, which, however, warrants further validation in clinical trials.
Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway
Authors: Li Zhen , Geng Jing , Xie Bingbing , He Jiarui , Wang Jing , Peng Liang , Hu Yinan , Dai Huaping , Wang Chen 
Published: March 2022

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with a poor prognosis. Although dihydromyricetin (DHM), extracted from vine tea and other Ampelopsis species, has been proven to have anti-inflammatory and antioxidant functions, the effects of DHM on IPF remain unclear.Methods: The effects of DHM on the differentiation, migration, proliferation, and respiratory functions of primary mouse lung fibroblasts (PMLFs) and primary human lung fibroblasts (PHLFs) were detected by western blotting, the Transwell assay, EdU staining, and the Mito Stress test. Then, the impacts of DHM on bleomycin (BLM)-induced pulmonary fibrosis were evaluated by pathological staining, western blotting, and coimmunofluorescence staining. The signaling pathway influenced by DHM was also investigated.Results: DHM could regulate the differentiation of fibroblasts to myofibroblasts and suppress the abnormal migration, proliferation, and respiratory functions of myofibroblasts induced by TGF-β1 or myofibroblasts from IPF patients. DHM could also alleviate pulmonary fibrosis induced by BLM. All these effects were achieved by regulating the STAT3/p-STAT3/GLUT1 signaling pathway.Conclusion: DHM could regulate the abnormal functions of myofibroblasts induced by TGF-β1 and myofibroblasts from IPF patients and alleviate pulmonary fibrosis induced by BLM; thus, DHM might be a candidate medicinal treatment for IPF.
Exercise Physiology Impairments of Patients With Amyotrophic Lateral Sclerosis: Cardiopulmonary Exercise Testing Findings
Authors: He Ji , Fu Jiayu , Zhao Wei , Ren Chuan , Liu Ping , Chen Lu , Li Dan , Zhou Lequn , Tang Lu , Liu Xiangyi , Ye Shan , Liu Xiaolu , Ma Yan , Zhang Yixuan , Ma Xinran , Zhang Linjing , Zhang Gaoqi , Li Nan , Fan Dongsheng 
Published: March 2022

Background and ObjectiveIn amyotrophic lateral sclerosis (ALS), progressive weakness significantly limits the ability to exercise. However, measurements of the impaired exercise function and their practical value to assess disease progression in ALS are scarce. Cardiopulmonary exercise testing (CPET) is a non-invasive accurate method used to comprehensively quantify exercise physiology in a variety of diseases. This study aimed to evaluate the clinical value of CPET and to explore its association with disease severity and prognosis prediction in ALS.MethodsA total of 319 participants were enrolled in this 3-year prospective study. After strict quality control, 109 patients with ALS and 150 age- and sex-matched healthy controls were included with comprehensive clinical assessment and follow-ups. The incremental ramp protocol for symptom-limited CPET was applied in both groups. The exercise physiology during peak effort exercise was systematically measured, including the overall aerobic capacity of exercise (VO2 peak) and the respective capacity of the exercise-involved organs [cardiac response (heart rate peak—HR peak), ventilatory efficiency (VE/VCO2 slope), breathing economy (VE/VO2 peak), and other relevant parameters]. Disease severity and progression were evaluated using recognized scales. Survival was monitored with regular follow-ups every 6 months.ResultsDecreased exercise capacity (VO2 peak &lt; 16 ml/kg/min) occurred more frequently in patients with ALS than in controls (44.95% vs. 9.33%, p &lt; 0.01). In patients with ALS, the average VO2 peak (16.16 ± 5.43 ml/kg/min) and HR peak [135 (112–153) bpm] were significantly lower (p &lt; 0.01) than in controls [22.26 ± 7.09 ml/kg/min; 148 (135–164) bpm], but the VE/VCO2 slope was significantly higher [28.05 (25.03–32.16) vs. 26.72 (24.37–29.58); p = 0.03]. In patients with ALS, the VO2 peak and HR peak were significantly correlated with disease severity and progression scores (p &lt; 0.05). Survival analyses revealed the VO2 peak and HR peak as protective indicators while the VE/VO2 peak as a detrimental indicator for the prognostic prediction in ALS (HR = 0.839, p = 0.001; HR = 0.967, p &lt; 0.001; HR = 1.137, p = 0.028, respectively).ConclusionOur prospective study quantified the significantly decreased exercise capacity in ALS through non-invasive CPET. The impaired VO2 peak and HR peak closely correlated with disease severity and independently predicted a worse prognosis. Our findings identified the clinical value of CPET as an objective indicator of disease progression in ALS.