bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geoid undulation prediction using ANNs (RBFNN and GRNN), multiple linear regression (MLR), and interpolation methods: A comparative study
Authors: Konakoglu Berkant , Akar Alper 
Published: December 2022

The present work aimed to develop a prediction model to estimate geoid undulation and to compare its efficiency with other methods including radial basis function neural network (RBFNN), generalized regression neural network (GRNN), multiple linear regression (MLR) and, ten different interpolation methods. In this study, the k-fold cross-validation method was used to evaluate the model and its behavior on the independent dataset. With this validation method, each of a k number of groups has the chance to be divided into training and testing data. The performances of the methods were evaluated in terms of the root mean square error (RMSE) mean absolute error (MAE), Nash–Sutcliffe efficiency coefficient (NSE), and correlation coefficient (R2) and using graphical indicators. The evaluation of the performance of the datasets obtained using cross-validation was done in two ways. If we accept the method having the minimum error result as the most appropriate method, the natural neighbor (NN) method in the DS#5 dataset gave better results than the other methods (RMSE=0.14173 m, MAE=0.09729 m, NSE=0.98986, and R2=0.99011. On the other hand, it has been observed that, the GRNN method exhibited the best performance, on average, with RMSE=0.18539 m, MAE=0.13676 m, NSE=0.98229, and R2=0.98249.
The content of complex psychedelic experiences resulting from inhalation of N,N-dimethyltryptamine
Authors: Kagan Stephen 
Published: December 2022

AbstractAimThis study examines narratives describing complex psychedelic experiences after smoking N,N-dimethyltryptamine.MethodsThe narrative accounts examined here were gathered from a variety of online sites and analyzed in order to discover themes, categories and patterns in the phenomenon of the resulting psychedelic experiences.ResultsSubjects reported seeing complex and unusual visual and synesthetic phenomena, leaving this world and entering into extraordinary places, encounters with a variety of strange entities, interactions with unusual objects and a wide variety of powerful feelings. The general categories of Places, Objects, Entities and Feelings were found in the phenomena experienced by people who smoked N,N-Dimethyltryptamine. These provided a framework within which more detailed subcategories were found and the range of most frequent to least frequent experiences were identified.DiscussionWhile DMT experiences are commonly described by people smoking N,N-dimethyltryptamine as indescribable, unique to everyone and taking place in a single domain called Hyperspace or the Hyperdimension, this research found distinct subcategories of frequently visited Places as well as frequently encountered Entities, Objects and Feelings. From these a more comprehensive understanding can be developed of the unusual and profound experiences resulting from inhalation of N,N,-Dimethyltryptamine.
The impact of overtourism on the residential well-being
Authors: Molnár-Csomós Ilona , Kiss Kornélia 
Published: December 2022

Overtourism has a number of negative impacts on both the attractiveness of tourist destinations and the way of life of the local residents. The period of tourism converging to almost nothing, which appears from time to time during the period marked by the outbreak and global spread of the COVID-19 pandemic, is suitable for examining the residents' perceptions of overtourism. In this study, the question of research focuses on the impact of overtourism on the residential well-being of local communities. Sentiment analysis was used to answer the research question, which proved to be a good tool for exploring the impacts of overtourism perceived by local residents in an unconventional way.
The results, based on 13,145 comments, support which sensory perception allowed by representational systems – such as sight, hearing, touch, taste, smell – is more significant in the case of the examined keywords. Knowing the correlations of overtourism and residential well-being the non-governmental organizations and the local government of the municipality – which providing housing for the residents – can effectively shape the factors of residential well-being, but in addition the local residents as well exposed to the environmental impacts of tourism can play a key role in shaping their own residential well-being.
Contraceptive awareness in post-natal patients in KIMS, Bangalore
Authors: Krishnegowda Smitha , Bhandari Ishwarya 
Published: December 2022

Background: Family planning can avert more than 30% of maternal deaths and 10% of child mortality if couples spaced their pregnancies more than two years apart. India was the first country in the world to launch the family planning programme in 1951. There exists a KAP gap i.e. a gap between knowledge, attitude, and practices regarding contraception. Healthcare workers have an important role to play to acknowledge the importance and right concept of contraception among married couples. This study aimed to assess the knowledge, awareness, and perception of contraception among postnatal women.Methods: A questionnaire-based study was conducted among postnatal inpatients and outpatients from September 2021 to November 2021. All postnatal patients in this hospital, willing to participate in the study, after a thorough written informed consent, patients were given pre decided questions for answering. Answers were noted, counselling was done.Results: Out of 200 women, 97% of the women were aware of at least 1 contraceptive method, the highest being of female sterilization (91%). The 22% of women have used contraception before. The 78% of women had never used contraception before, main reason was that they wanted to conceive (46%) followed by fear of side effects (29%). Regarding willingness to use the contraception after counselling, female sterilization (32%) was the preferred method followed by copper-T (22%). The most common source of information was by relatives was 33%.Conclusions: There is a large gap between the awareness and practice of contraception. Proper education of both partners, increasing female literacy, socio economic upliftment, effective health care system is needed. After delivery, during immediate postpartum period, maximum women wish for contraception Hence these women can be served by family planning services before discharge from hospital to ensure the acceptance of contraceptive practices among them. This would curb unwanted pregnancies and its future consequences.
DE QUE EDUCAÇÃO NECESSITAMOS? Por uma educação pública e contra-hegemônica
Authors: Santos Ana Maria Marques , Arcenio Cláudia Rodrigues do Carmo , Lino Lucília Augusta , Arruda Maria da Conceição Calmon , Azevedo Patrícia Bastos de 
Published: December 2022

Este artigo propõe um diálogo entre especificidades da Formação de Professores, sob a ótica do PARFOR, e a proposta, encampada pelo governo federal, pela regulamentação da Educação Domiciliar. Busca-se compreender as relações entre o projeto governamental e seus impactos no espaço macro e micro da Educação brasileira. Partimos dos textos apresentados na JOINPP 2019, na mesa temática “De que educação necessitamos?”, que problematizaram o desmonte das políticas educacionais marcado pela deslegitimação das conquistas históricas dos trabalhadores, perda de direitos e desconstrução da educação pública. Este texto articula as reflexões sobre o PARFOR, como política nacional de formação de professores, suas correlações formativas para a ação/trajetória de mulheres-professoras, suas práticas de letramento escolar e o projeto neoliberal de privatização e desfinanciamento da educação pública.
Evaluation of quality of life in patients with varicose veins of the lower extremities
Authors: Donmez Gamze Sengul , Basak Tulay 
Published: December 2022

In this descriptive study, the presence of any association between risk factors and quality of life (QOL) in patients with lower extremity varicose veins was determined using a disease-specific scale. This study included 200 patients admitted to the cardiovascular surgery polyclinic of a hospital between January and December 2018 with chronic venous insufficiency and lower extremity varicose veins. The data collection form was applied to the patients who accepted the study after appropriate information was given about the research by a face-to-face interview method. The QOL was found to be higher in the 51â€“70 age group, with a fixed standing time of less than 7 hours a day, without constipation and with one or more chronic diseases other than varicose veins. About 83.5% of the patients had used compression stockings (CS) and 40.5% of the patients had previously used complementary treatment methods. The QOL scores of the patients with lower extremity varices were found to be low. Causes of dissatisfaction of the patients when using CS include swelling of the feet and fingers, pain and numbness, itching of the wrist, firmness, wrinkles, keeping warm, gliding down the leg and not being cosmetic.
Keywords: Varicose veins, chronic venous insufficiency, compression stockings, quality of life, nurseâ€™s role
Assessment of cigarette taxation as a sin tax in Turkey in terms of tax loss
Authors: Canbay Tulin 
Published: December 2022

In the literature, taxes levied by the governments on some goods considered as demerit goods to discourage the society from using the sad goods are called the sin taxes . Goods such as unheal thy foods , cigarette and alcohol are among the said goods consumed legally and commonly by the individuals in the society. Taxes l evied on cigarette are an important in come source for the governments . In the present study, taxes on tobacco products , taxi ncome due to cigarette taxes in Turkey and thus th e tax l oss due to increasings mugglingin consequence of price increase are addressed. As Paul Leroy Beaulieu says, â€œtoo much tax kills taxâ€ (â€œTrop d'impot tue t-il l'impotâ€).
Keywords : Sin taxes ,taxes , demerit goods , cigarette taxati on, tax loss
A multimodal approach to reading language-image-text combinations
Authors: Leibrandt Isabella 
Published: December 2022

The project presented here is an experience report carried out in a university C1 German course and based on the reading of F.C. Delius' novel The Walk from Rostock to Syracuse. This article aims to provide suggestions for the practical application and the linking types of language-image texts. The students re-live the protagonist's escape on a sailing boat across the Baltic Sea from Eastern Germany during Germany’s separation from the West to fulfill his dream of a journey through Italy. This text lends itself to be explored in a multimodal way, as it presupposes implicit knowledge that includes certain historical and cultural contextual references. Therefore, information and extra-textual images are necessary to visualise and understand the narrative. Both the reading process and the results of the multimodal project are recorded in a reading blog. This offers a variety of possibilities for linguistic expression and acquisition as the multimodal approach provides varied resources for activity-based reading and communicative learning among peers.
Keywords: Images, intertextuality, literacy, multimodality, reading comprehension;
The influence of tympanic membrane perforation site on the hearing level of conductive hearing loss in chronic suppurative otitis media
Authors: Wicaksono Adhika Banu , Samodra Edhie , Fitriana Melysa , Trihandoko Feri , Khoiria Anisa Haqul , Dewanti Dyah Ayu Kartika 
Published: December 2022

Chronic suppurative otitis media (CSOM) is an infection of the middle ear cavity both partially and totally. It is characterized by ear discharge through a tympanic membrane perforation for over a period of 2 to 6 weeks. Hearing loss is the most common complication of CSOM. One of the degrees of hearing loss in tympanic membrane perforation is depending on the site of perforation, but this premise is still debatable because of pros and contras by some researchers. This study aimed to assess the degree of hearing loss in relation to the site of tympanic membrane perforation. A cross-sectional prospective study design was performed involving 43 patients of safe type CSOM who came to the Department of Otolaryngology Head and Neck Surgery from the period January 2016 to November 2018. All subjects were divided into 4 groups based on the site of perforation. There was a perforation in the posteroinferior, the posterosuperior, the anteroinferior, and the anterosuperior. A statistical analysis using Anova along with multivariate analysis was conducted. Our result showed that the most common site of tympanic membrane perforation was at the anteroinferior (30 samples, 59.8%). The highest hearing threshold was seen at posteroinferior with a mean hearing level of 37.7±2.0 dB, anteroinferior with a mean hearing level of 31.7±0.7 dB, anterosuperior with a mean hearing level 30.7±1.4 dB, and posterosuperior mean hearing level 28.9±1.5 dB. The difference was found significant with p=0.004. Posteroinferior tympanic membrane perforation had a higher number of hearing loss compared to the other sites. In conclusion, the tympanic membrane perforation site has an important role in the hearing level of conductive hearing loss in CSOM.
Predicting Dynamic Effects of Large Earthquakes in Areas of Degrading Permafrost (Baikal-Mongolia Region)
Authors: Dzhurik V.I. , Bryzhak E.V. , Batsayhan Ts. , Serebrennikov S.P. 
Published: December 2022

Abstract
—The study addresses basic problems of modern geodynamics and seismicity of the Central Asian lithosphere. It aims at predicting dynamic effects of large earthquakes for seismic safety of the Baikal–Mongolia region. Special focus is made on the seismic behavior of areas where seismic risk zoning is problematic because of permafrost. The paper presents synthesis of previous and new data on ground responses to large earthquakes in specific territories of the Baikal–Mongolia region with complex cryological conditions. The results include shaking intensity patterns and predicted seismic parameter values for degraded permafrost in zones of different climates and seismicity levels. The obtained prediction maps can make reference in studies of variable permafrost responses to temperature, seismic, and mining-related impacts.
Global Hypertension Guidelines; Are Central Haemodynamics Critical and Neglected?
Authors: Phillips Robert , Carlier Stéphane , Scalia Alessandro , Brierley Joe 
Published: December 2022

Abstract
Background: Hypertension (HTN) is an elevated blood pressure (BP) compared to normative data. However, physiologically it is a product of the central haemodynamic variables of stroke volume (SV), cardiac output (CO) and systemic vascular resistance (SVR) (BP = (SV x HR) x SVR). Multiple global clinical guidelines recommend anti-hypertensive therapy to reduce BP, yet effective BP control of people diagnosed with HTN remains persistently dismal at ~25% while central haemodynamics are ignored. BP is a cornerstone of HTN practice, yet is an insensitive measure of circulation and sheds little light on the critical therapeutic central haemodynamic variables of SV, CO and SVR, and ultimately may limit our understanding of the pathophysiology of HTN and its management.
Methods: Word searches were conducted on Australian, Canadian, Chinese, European, Japanese, Singaporean, UK, US and International hypertension guidelines using the Adobe or Microsoft word count function, with specific searches made for BP, and central haemodynamic parameters, and the results tabulated.
Results: A total of 695 pages and 478,537 words were published in nine HTN guidelines by representative global organisations, with BP parameters mentioned 7,535 times, and central haemodynamic parameters mentioned 47 times. All guidelines recommended BP target values and pressure-led therapies, while no central haemodynamic targets were noted.
Conclusions: Although physiologically core to the aetiology and treatment of HTN, central haemodyanmic parameters are ignored in current practice guidelines. Poor global outcomes suggest the inclusion of central haemodynamics in everyday practice may improve our understanding of HTN and facilitate the delivery of precise anti-hypertensive therapy.
Recovery of proliferative fibroblast cells from refrigerated sheep skin after different postmortem time intervals and their characterization
Authors: Singh Mahipal , Ma Xiaoling 
Published: December 2022

Abstract
Background
Postmortem tissues are a potential source of stem/progenitor cells for cellular therapies, preservation of germplasm and revival of endangered and/or dead species by cloning. How long they can be recovered after animal death, however, is not known precisely. The objective of this study was to evaluate the window of postmortem interval (PMI) within which live and proliferative cells can be recovered from refrigerated sheep skin. Ear skin was procured from animals from slaughterhouse and stored at 4°C in the lab. Small explants (2–3 mm2) were then cultured in DMEM media supplemented with 10% FBS, 50 units/mL of penicillin, 50 µg/mL of streptomycin, and 2.5 µg/mL of fungizone after different PMI. Outgrowth of cells around the explants was scored after 10–12 days of culture at 37°C in a CO2 incubator and cells from selected PMI were sub-cultured for 3–5 times and characterized with respect to their growth profiles, genetic stability, cryopreservation ability and gene expression.
Results
A total of 474 explants adhered to dish surface, of which 369 (77.89%) exhibited outgrowth in various PMI including 34.79% of 65-days postmortem (dpm) interval. We observed recovery of proliferative cells up to a maximum of 65 days of PMI. Percent of explants exhibiting outgrowth as well as relative confluence of outgrowing cells decreased with increasing PMI. Comparative Growth Curves and GFP expression patterns, upon transfection with a GFP plasmid, were not significantly different in 0-dpm and 65-dpm cell populations (p < 0.05). Recovered cells cryopreserved with > 80% post-freezing cell-viability and were passaged up to 35 times in in vitro cultures. The cytogenetic analysis of 65-dpm tissue derived cells exhibited a normal female sheep karyotype without any genetic aberrations.
Conclusions
These results show that normal proliferative cells can be recovered from sheep skin up to about 2 months postmortem, if tissues are kept refrigerated. To our knowledge this is the first report of recovering proliferative cells from mammalian tissues up to such a long time of > 2 months after death. The discovery has potential applications in preserving veterinary and livestock germplasm after death to revive in future by cloning as well as in cellular therapies in human and veterinary medicine.
Association of prenatal exposure to opioids, cannabis, and polysubstance use with cord blood DNA methylation patterns in a multiancestry cohort
Authors: Garrison-Desany Henri , Howerton Ellen , Hong Xiumei , Maher Brion , Pearson Colleen , Zuckerman Barry , Wang Guoying , Fallin M. Daniele , Beaty Terri , Liang Liming , Wang Xiaobin , Ladd-Acosta Christine 
Published: December 2022

Abstract
Background: Blood DNA methylation patterns are highly predictive of prenatal exposure to smoking and differential methylation has been associated with maternal alcohol use. We extended this to determine whether DNA methylation patterns in cord blood are associated with prenatal exposure to opioid, cannabis, and polysubstance use. We also evaluated whether DNA methylation patterns have predictive utility.
Methods: We examined 932 mother-child pairs in the Boston Birth Cohort between 1998-2020 with cord blood DNA methylation and maternal substance use data. For each substance, we performed adjusted linear regression analysis at 865,859 CpG sites to identify related methylation changes. We generated scores using summary statistics for each exposure and assessed predictive ability using cross-validation and receiver operating characteristic curves. Specificity of methylation associations was evaluated by assessing overlap across exposure summary statistics, and using logistic regression for methylation scores, adjusted for concurrent use.
Results: We identified methylation changes at 72, 21, and 1 novel CpG associated with prenatal exposure to opioids, cannabis, and polysubstance use respectively, at epigenome-wide significance (P<1e-6). Comparing CpGs across exposure groups and with previous consortia-generated summary statistics for smoking and alcohol revealed few overlapping CpGs across exposures. Methylation scores were highly predictive and exposure-specific, with area under the curve accuracy of 91% for opioids, 90% for cannabis, and 93%-98% depending on polysubstance number.
Conclusion: We identified novel DNA methylation differences in cord blood associated with prenatal exposure and showed that methylation scores are highly predictive of substance exposures. These CpGs provide biologic insights for reducing the impact of substance exposure. These findings may serve as a biomarker of prenatal substance exposure for future studies and potential clinical utility.
Three Contactless Sleep Technologies Compared with Polysomnography and Actigraphy in a Heterogenous Group of Older Men and Women in a Model of Mild Sleep Disturbance
Authors: RAVINDRAN KIRAN KUMAR GURUSWAMY , Monica Ciro della , Atzori Giuseppe , Lambert Damion , Hassanin Hana , Revell Victoria , Dijk Derk-Jan 
Published: December 2022

Abstract
Contactless sleep technologies hold promise for longitudinal, unobtrusive sleep monitoring in health and disease at scale, but few have been evaluated in older people. The performance of three contactless sleep technologies (a bedside radar [Somnofy] and two under-mattress devices [Withings sleep analyser and Emfit-QS]) were compared to polysomnography and actigraphy [Actiwatch Spectrum] in a sleep laboratory study during a 10-hour time in bed period which induced mild sleep disturbance. The data were collected in a group of older men and women (n=35; 70.8±4.9 years; 14 women) several of whom had health problems and/or sleep apnoea. We conducted a comprehensive and rigorous evaluation of the devices involving estimation of robust performance metrics (both sleep summary and epoch by epoch concordance) for classification of sleep vs wake and NREM and REM sleep stages. All devices overestimated total sleep time and the sleep stage estimation was unsatisfactory in this group of older people in whom sleep efficiency was relatively low. Our findings indicate that even though these devices provide some useful information on sleep behaviour, the performance of contactless sleep technologies requires improvement before they can serve as an alternative to polysomnography and actigraphy for estimating most sleep variables in older individuals.