bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Diagnostic Exosomal LncRNA-miRNA-mRNA Biomarkers in Colorectal Cancer Based on the ceRNA Network
Authors: Zhao Yajing , Song Xingguo , Song Xianrang , Xie Li 
Published: September 2022

Background: Colorectal cancer (CRC) is currently the fourth most common cancer worldwide. The roles of exosomal competing endogenous RNAs (ceRNAs) in CRC remain unclear. In this study, we constructed an exosomal ceRNA network to identify the core ceRNAs and investigate the diagnostic biomarkers in CRC.Methods and Patients: Serum exosomes were isolated from four CRC patients and two healthy donors by ultracentrifugation, and then subjected to RNA isolation, sequencing and microarray. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) analyses were performed to identify functional enrichment implications of differentially expressed exosomal mRNAs. TargetScan and miRanda were used for identifying the miRNA-mRNA and miRNA-LncRNA interactions. The predicted lncRNAs and mRNAs were intersected with the differentially expressed genes, for which the screening criterion was fold change &gt;1.5 in the microarray. Differentially expressed exosomal miRNAs were identified in the GSE71008 dataset, and differentially expressed mRNAs (DEmRNAs) were further summarized from The Cancer Genome Atlas (TCGA) database.Results: A total of 1186 exosomal DEmRNAs, 2088 exosomal DElncRNAs and 29 exosomal miRNAs were detected in CRC patients compared to the healthy donors. Functional enrichment analysis suggested that exosomal DEmRNAs might participate in pathways related to carcinogenesis and development of cancer. An exosomal ceRNA regulatory network of CRC was constructed based on 40 lncRNAs, two miRNAs, and five mRNAs. Exosomal miR-150-5p and miR-10b-5p expression levels were increased in healthy donors compared with CRC patients in the GSE71008 dataset, and five DEmRNAs (TOMM70A, RBM48, BEND3, RHOBTB1, and ADAMTS2) were significantly upregulated in TCGA database. Two potential exosomal regulatory axes of lncRNA G016261-miR-150-5p-RBM48 and lncRNA XLOC_011677-miR-10b-5p-BEND3 were identified from the network.Conclusion: The current study revealed potential molecular biological regulation pathways and diagnostic biomarkers through the exosomal ceRNA regulatory network.
The TGF-β Receptor Gene Saxophone Influences Larval-Pupal-Adult Development in Tribolium castaneum
Authors: Li Jingjing , Yin Letong , Bi Jingxiu , Stanley David , Feng Qili , Song Qisheng 
Published: September 2022

The transforming growth factor-β (TGF-β) superfamily encodes a large group of proteins, including TGF-β isoforms, bone morphogenetic proteins and activins that act through conserved cell-surface receptors and signaling co-receptors. TGF-β signaling in insects controls physiological events, including growth, development, diapause, caste determination and metamorphosis. In this study, we used the red flour beetle, Tribolium castaneum, as a model species to investigate the role of the type I TGF-β receptor, saxophone (Sax), in mediating development. Developmental and tissue-specific expression profiles indicated Sax is constitutively expressed during development with lower expression in 19- and 20-day (6th instar) larvae. RNAi knockdown of Sax in 19-day larvae prolonged developmental duration from larvae to pupae and significantly decreased pupation and adult eclosion in a dose-dependent manner. At 50 ng dsSax/larva, Sax knockdown led to an 84.4% pupation rate and 46.3% adult emergence rate. At 100 ng and 200 ng dsSax/larva, pupation was down to 75.6% and 50%, respectively, with 0% adult emergence following treatments with both doses. These phenotypes were similar to those following knockdowns of 20-hydroxyecdysone (20E) receptor genes, ecdysone receptor (EcR) or ultraspiracle protein (USP). Expression of 20E biosynthesis genes disembodied and spookier, 20E receptor genes EcR and USP, and 20E downstream genes BrC and E75, were suppressed after the Sax knockdown. Topical application of 20E on larvae treated with dsSax partially rescued the dsSax-driven defects. We can infer that the TGF-β receptor gene Sax influences larval-pupal-adult development via 20E signaling in T. castaneum.
Brief mindfulness training for Canadian public safety personnel well-being
Authors: Stevenson Renae M 
Published: September 2022

The body of research demonstrating the psychological and physiological benefits of mindfulness-based interventions (MBIs) is robust and spans decades, yet its adaptation for a population at significantly higher-than-average risk of negative health outcomes, operational stress injuries, moral injury, and burnout is in its infancy. Failing to address these risks has costs not just for the well-being of public safety professionals (PSPs), but for their families, their agencies, and their communities. Public safety work requires a high standard of ethical decision-making and compassionate contact with the communities served. The public safety oversight of agency, government, and training institutes must prepare its professionals to deliver exemplary levels of service as well as establish trauma-competent training and support frameworks that are evidence-based to protect PSP well-being. Remedying historically ineffective training with evidence-based models not only addresses the complexity of operational stress injuries (OSIs) but also the needs of social justice reform. Canada’s contribution to the body of research using evidence-based MBIs for PSP well-being is scarce. This literature review informs leaders, policymakers, change agents, and researchers not only of the need for such critical research in Canada, but of its current state and important considerations for its design. The efficacy of MBI is discussed, evaluating recent quantitative, qualitative, and mixed-methods studies towards charting a brief MBI (bMBI) logistically deliverable, attentive to the PSP cultural context needs and barriers, and which facilitates sustainable skill-building in attention, awareness, and compassion.
Analisa Dan Visualisasi Data Penjualan Menggunakan Exploratory Data Analysis Pada PT. Telkominfra
Authors: Wibowo Aditya 
Published: September 2022

Bisnis Telkominfra yang semakin berkembang dengan proyek-proyek yang besar dengan tingkat kompleksitas yang tinggi sehingga menyulitkan dalam melakukan proses pengolahan data. Dengan kondisi saat ini proses pengolahan data mulai dari melakukan export, melakukan filterisasi data, melakukan analisis terhadap data, serta membuat visualisasi data masih dilakukan dengan menggunakan file excel, hal ini memakan waktu yang cukup lama sehingga proses pengambilan keputusan yang dilakukan oleh manajemen menjadi kurang optimal.
Tujuan penelitian ini diharapkan dapat memberikan informasi dan pengetahuan kepada user terkait secara real time sehingga bisa mempercepat proses pengambilan keputusan. Maka dari itu diperlukan data analisis menggunakan metode Exploratory Data Analysis (EDA), EDA dilakukan mulai dari pemahaman obyek bisnis dimana pendapatan/penjualan sebagai salah satu metric yang digunakan untuk melihat profil kinerja perusahaan. Hasil penelitian ini terlihat bahwa perbandingan pendapatan setiap bulannya, perbandingan pendapatan pada masing masing produk dan komposisi realisasi pendapatan terendah sehingga bisa menjadi bahan evaluasi oleh manajemen, dan hasil EDA tersebut akan ditampilkan dalam sebuah aplikasi visualisasi data.
PEMBANGUNAN APLIKASI VIRTUAL INVENTORY SYSTEM (VIS) BERBASIS WEB MENGGUNAKAN FLASK FRAMEWORK
Authors: Eben Haezer Eben Haezer Yena Kristianto , Setiyawati Nina 
Published: September 2022

Dalam bisnis di bidang retail PT. XYZ mencari cara dan terus berinovasi agar dapat mengembangkan bisnis distribusi retail dengan pesat. Untuk mengakomodasi dan memperlancar proses transaksi tersebut, PT XYZ memerlukan beragam sistem serta aplikasi yang dapat mendukung dan mempermudah proses transaksi tersebut. Oleh karena itu PT XYZ membangun sebuah sistem yang bernama Virtual Inventory System (VIS) menggunakan Oracle form. Beriringnya waktu, didapatkan bahwa aplikasi tersebut memiliki kekurangan seperti biaya pemeliharaan aplikasi semakin tinggi, teknologi yang digunakan sudah tertinggal, hanya dapat berjalan pada satu platform saja. Oleh karena itu pada penelitian ini dilakukan pengembangan ulang aplikasi Virtual Inventory System menggunakan Flask Framework. Pada penelitian ini terdapat lima tahapan, yaitu: Identifikasi Masalah, Pengumpulan Data, Perancangan Sistem meliputi alur proses sistem Unified Modelling Language (UML) yang digambarkan dengan use case diagram dan activity diagram, Perancangan Antarmuka, Perancangan Database, Pembangunan Aplikasi, Pengujian sistem. Penelitian ini menghasilkan modul Pre Order Manual (PO Manual) di dalam aplikasi VIS yang nantinya akan digunakan pada Head Office untuk mengatur supplier, harga barang dan mencetak faktur hasil dari transaksi barang yang sudah dilakukan. Keuntungan menggunakan web adalah bisa diakses di segala platform (multiplatform) sehingga lebih mempermudah user dalam mengakses aplikasi VIS ini.
ANALISIS KINERJA KOMPRESI CITRA DWT DAN FRAKTAL PADA TRANSMISI CITRA DENGAN SISTEM SC-FDMA
Authors: Setiabudi Dodi , Wahyu Herdiyanto Dedy , Felayati Akbar 
Published: September 2022

Perkembangan teknologi telekomunikasi memliki peranan penting dalam kecepatan proses pengiriman citra. SC-FDMA merupakan teknologi akses jamak dengan teknik single carrier yang membagi bandwidth kanal dan memiliki keunggulan nilai PAPR yang rendah. Namun ukuran file citra yang besar akan menjadi masalah pada media penyimpanan maka diperlukan adanya kompresi. Kompresi DWT dan Fraktal merupakan salah satu kompresi lossy yang dapat mengecilkan ukuran citra. Penelitian ini bertujuan untuk mebandingkan kinerja antara kompresi DWT dan Fraktal menggunakan sistem SC-FDMA. Penelitian dijalankan melalui modulasi QPSK, 16-QAM, dan 64-QAM dengan parameter PSNR, SSIM, dan waktu transmisi . Berdasarkan hasil pengujian diketahui bahwa metode DWT dengan nilai PSNR 41,8594 dB menghasilkan kualitas citra yang lebih baik daripada metode Fraktal dengan nilai PSNR 30,5940 dB. Sedangkan kinerja waktu transmisi dari kompresi Fraktal lebih baik dengan waktu rata-rata 9,8274 detik daripada kompresi DWT dengan waktu 13,1121 detik.
Hubungan Tingkat Pengetahuan Keluarga dengan Efikasi Diri Pasien Pasca Stroke dalam Mencegah Serangan Berulang
Authors: Dewi Ni Luh Putu Thrisna , Wati Ni Made Nopita 
Published: September 2022

Family has important role in controlling the risk factor of stroke even controlling a repeated attack. The knowledge of the family also contributes in the patient's self evication and it leads to the patient's behavior in the prevention of repeated attack. The purpose of the research is to know the relation the family knowledge level with the post stroke patient's self evication in preventing repeated attack. The research is quantitative with descriptive correlation research design which uses cross sectional approach, measure and collected together at once in the same time. The population in this research are all the stroke patient and the family when they were visiting neurology polyclinic in one of hospital in Bali 53 people by using total sampling technique. The research found that most of the family knowledge that does not come with a low patient's self evication which are 24 people (43,3%), enough family knowledge which come with enough patient's self evication which are 17 people (32,0%) and the family which have a high knowledge most of the patient that they take care also have high stroke self evication which are 3 people (5,6%) with P value 0,000 and r = 0,765 which means there is a relative between the family knowledge with a patient self evication. The stroke patient's self evication in changing the patient behavior fixing meal pattern and life style in two adaptive direction in future.
PROFIL KONDISI FISIK ATLET BADMINTON PADA KLUB FORZA YUNIOR TAHUN 2021
Authors: Ahmad Khoirul Falah  , Slamet Santoso  , Untung Nugroho  
Published: September 2022

Tujuan dari penelitian ini adalah untuk mengetahui profil kondisi fisik atlet badminton pada klub forza yunior tahun 2021. Metode yang digunakan dalam penelitian ini adalah penelitian deskriptif kuantitatif. Subyek dalam penelitian ini adalah atlet badminton pada Klub Forza Yunior Tahun 2021 yang berjumlah 30 peserta. Teknik pengumpulan yang diperlukan dalam penelitian ini melakukan tes komponen kondisi fisik yang meliputi kecepatan yang diukur dengan lari sprint 20 meter, power tungkai yang diukur dengan loncat tegak, kelentukan yang diukur dengan sit and reach, kekuatan otot perut yang diukur dengan sit up, kekuatan otot lengan yang diukur dengan push up, kelincahan yang diukur dengan lari 4x5 meter, dan daya tahan aerobik yang diukur dengan MFT. Berdasarkan hasil analisis data tes lari 20 meter diperoleh hasil “cukup” persentase 43,3%, tes loncat tegak diperoleh hasil “baik” sebanyak 53,4%, tes kelentukan diperoleh hasil “kurang” persentase 50%, tes kekuatan otot perut diperoleh hasil “baik” persentase 40%, tes kekuatan otot lengan diperoleh hasil “baik” persentase 33,3%, tes kelincahan diperoleh hasil “sangat baik” persentase 33,3% dan daya tahan aerobik di peroleh sebagian hasil “sangat baik” persentase 30%.
SURVEI TINGKAT KEBUGARAN JASMANI SISWA KELAS IV, V DAN VI SD NEGERI 02 CELEP KECAMATAN NGUTER KABUPATEN SUKOHARJO TAHUN 2022
Authors: Rizky Adi Nugroho  , Rima Febrianti  , Arif Rohman Hakim  
Published: September 2022

Tujuan dari penelitian ini adalah untuk mengetahui seberapa baik tentang tingkat kebugaran jasmani siswa kelas IV, V dan VI SD Negeri 02 Celep Kecamatan Nguter Kabupaten sukoharjo tahun 2022. Penelitian ini merupakan penelitian deskriptif kuantitatif. Metode yang digunakan adalah survei.Sampel dalam penelitian ini adalah siswa kelas IV, V dan VI SD Negeri 02 Celep KecamatanNguter KabupatenSukoharjo Tahun 2022 yang berjumlah 71 siswa, diambil menggunakan teknik total sampling. Instrumen yang digunakan untuk mengukur variabel penelitian adalah tes TKJI untuk usia 10 – 12 tahun yaitu : 1) Lari 40 meter, 2) Gantung siku tekuk, 3) Baring duduk 30 detik, 4) Loncat tegak, 5) Lari 600 meter. Teknik analisis data menggunakan statistik deskriptif kuantitatif yang disajikan dalam bentuk persentase. Berdasarkan hasil penelitian menunjukkan bahwa survei tingkat kebugaran jasmani kelas IV, V dan VI SD Negeri 02 Celep Kecamatan Nguter Kabupaten Sukoharjo tahun 2022 berada pada kategori “Kurang”sebesar 56,3% (40 siswa).
Capacitación docente para el uso y la adaptación de un modelo didáctico de escritura para la educación primaria básica
Authors: Ariza Duarte Sindy Liseth , Ramírez Ruth 
Published: September 2022

El propósito del estudio fue capacitar a maestros de una escuela primaria en Colombia para adoptar un modelo de escritura (Flower y Hayes, 1981, 1996). El modelo de escritura se basa en un proceso de planificación, producción, revisión y metacognición. Se siguió el proceso del modelo de capacitación de Joyce y Shower (2002) para capacitar a los maestros.
Un diseño cualitativo de investigación-acción práctica enmarcó el estudio. Entre los hallazgos obtenidos, la evidencia mostró (a) el enriquecimiento de las concepciones y prácticas de los docentes participantes, (b) las oportunidades didácticas que los docentes adaptaron y (c) la necesidad de promover la reflexión metacognitiva en la escritura de los estudiantes. Los hallazgos también muestran la importancia de un proceso de capacitación intencional para los maestros y el modelo de escritura de construcción colectiva reflexiva para los estudiantes.
Pengaruh Profesionalisme dan Etika Profesi terhadap Tingkat Materialitas Badan Pemeriksa Keuangan RI Perwakilan Provinsi Sulawesi Selatan
Authors: Kambuaya Maylen K. P. 
Published: September 2022

Penelitian ini bertujuan untuk mengetahui Pengaruh Profesionalisme dan Etika Profesi terhadap Tingkat Materialitas Badan Pemeriksa Keuangan RI Perwakilan Provinsi Sulawesi Selatan. Penelitian ini menggunakan desain studi korelasional dengan instrumen kuesioner. Metode analisis yang digunakan adalah regresi linier berganda.
Populasi dalam penelitian ini adalah 80 auditor yang bekerja di BPK RI Perwakilan Sulawesi Selatan. Teknik pengambilan sampelnya, non probability sampel yang merupakan teknik pengambilan sampel yang tidak memberikan peluang sama untuk dipilih menjadi sampel. Makanya dari 80 responden, terpilih 50 responden untuk menerima kuesioner, dan yang kembali hanya 35 kuesioner. Sisanya sebanyak 15 kuesioner, tidak kembali.
Hasil penelitian ini menunjukkan bahwa, Profesionalisme, dan Etika Profesi berpengaruh terhadap Tingkat Materialitas Badan Pemeriksa Keuangan RI Perwakilan Provinsi Sulawesi Selatan.. Variabel Etika profesi merupakan variabel yang paling dominan pengaruhnya terhadap Tingkat Materialitas Badan Pemeriksa Keuangan RI Provinsi Sulawesi Selatan.
Walter: A Tool for Predicting Resolved Stellar Population Observations with Applications to the Roman Space Telescope
Authors: Lancaster Lachlan , Pearson Sarah , Williams Benjamin F. , Johnston Kathryn V. , Starkenburg Tjitske K. , Kado-Fong Erin , Seth Anil C. , Bell Eric F. 
Published: September 2022

Abstract
Studies of resolved stellar populations in the Milky Way and nearby galaxies reveal an amazingly detailed and clear picture of galaxy evolution. Within the Local Group, the ability to probe the stellar populations of small and large galaxies opens up the possibility of exploring key questions such as the nature of dark matter, the detailed formation history of different galaxy components, and the role of accretion in galactic formation. Upcoming wide-field surveys promise to extend this ability to all galaxies within 10 Mpc, drastically increasing our capability to decipher galaxy evolution and enabling statistical studies of galaxies’ stellar populations. To facilitate the optimum use of these upcoming capabilities, we develop a simple formalism to predict the density of resolved stars for an observation of a stellar population at fixed surface brightness and population parameters. We provide an interface to calculate all quantities of interest to this formalism via a public release of the code walter. This code enables calculation of (i) the expected number density of detected stars; (ii) the exposure time needed to reach certain population features, such as the horizontal branch; and (iii) an estimate of the crowding limit, among other features. We provide a limited test of the code and formalism of the paper against existing resolved star observations. These calculations will be very useful for planning surveys with NASA’s upcoming Nancy Grace Roman Space Telescope (Roman, formerly WFIRST), which we use for example calculations throughout this work.
Momentum Enhancement from a 3 cm Diameter Aluminum Sphere Striking a Small Boulder Assembly at 5.4 km s−1
Authors: Walker James D. , Chocron Sidney , Grosch Donald J. , Marchi Simone , Alexander Amanda M. 
Published: September 2022

Abstract
An impact experiment was performed with a target of relevance to the upcoming DART impact. In this experiment, a collection of stones that is similar to a rubble pile was the target, though it was necessary to hold the stones in place (in this case with cement) since the target was hung vertically to perform the experiment. The stones–cement target has a higher density and a lower porosity than expected for Dimorphos, with the density being 2.92 g cm−3. A 3 cm diameter aluminum sphere was launched at a speed of 5.44 km s−1, which is similar to the anticipated 6.1 km s−1 impact speed of DART. The stones–concrete target was completely disassembled by the impact. The target was mounted on a pendulum. The swing of the pendulum was measured and from it the momentum enhancement

β
=

3.4

−
1.0

+
0.1

was measured. Due to possible lateral expansion of debris material, this value is a lower bound on the momentum enhancement that would be imparted to an extended target.
L’IAE : un monde social à la reconquête du pouvoir d’agir au sein des politiques publiques d’insertion
Authors: Balzani Bernard 
Published: September 2022

Depuis près de quinze ans, nous travaillons à partir de l’hypothèse que l’insertion par l’activité économique traverse une période historique de transformation tant sur le plan des représentations (instrumentalisation par les pouvoirs publics, incompréhension de l’opinion publique, déni de reconnaissance chez les responsables) que sur celui de l’efficacité des outils mis en œuvre dans ces organisations. Ces processus produisent une « crise » de valeurs chez les acteurs engagés dans ce mouvement de « décomposition et de recomposition ».
L’ISIC, pour redonner du sens au travail social
Authors: Kowalczuk Sylvie 
Published: September 2022

L’accompagnement social est bousculé par la dureté des situations, les problématiques extrêmes, les précarités multiples, avec en toile de fond des injonctions, procédures et dispositifs allant parfois à l’encontre du travail social dans son acceptation originelle : « Il participe au développement des capacités des personnes à agir pour elles-mêmes et dans leur environnement. » L’ isic est le lieu qui réunit tous ces principes qui donnent corps au travail social. Et pourtant, c’est une pratique encore trop peu utilisée.
Comparative Study of Postoperative Analgesic Effects of Intraoperative Levobupivacaine Local Infiltration Anesthesia and Transversus Abdominis Plane Block Following Gynecologic Laparoscopy
Authors: Otake Akiko , Sasamoto Naoko , Sato Noriko , Kumasaka Ryota , Yamamoto Yoshimitsu , Adachi Kazushige 
Published: September 2022

Objectives:
We aim to assess the postoperative analgesic effect of intraoperative levobupivacaine local infiltration anesthesia (LA) and transversus abdominis plane (TAP) block in gynecologic laparoscopy.

Materials and Methods:
We conducted a retrospective analysis on the data of 260 patients treated by gynecologic laparoscopy (adnexal surgery, hysterectomy, and myomectomy) between January 2019 and December 2020 at Minoh City Hospital, Osaka Japan. Patients were divided into two groups: intraoperative LA group and TAP block group. We assessed clinical characteristics, surgical results, postoperative numerical rating scale (NRS) pain scores, and the frequency of analgesic use up to 24 h after surgery in overall and by each type of surgery. Pearson's χ2 test, Fisher's exact test, and Wilcoxon/Kruskal–Wallis test were used for statistical analysis. Multiple regression analysis was used for multivariate analysis.

Results:
NRS pain score was statistically significantly higher in the LA group than in the TAP group 1 h after surgery in overall (P = 0.04), with NRS difference of 0.4 which was not clinically significant. No significant differences were observed in NRS pain scores at 3, 6, 12, and 24 h after surgery or in the frequency of analgesic use up to 24 h after surgery in overall and by type of surgery. Endometriosis was associated with increased postoperative pain at 1 h after surgery in adnexal surgeries (P = 0.04) and suggestive for all surgeries. Younger age was related to more frequency of analgesic use up to 24 h after surgery in overall, adnexal surgeries, and hysterectomy.

Conclusion:
Intraoperative levobupivacaine LA may have similar postoperative analgesic effects as TAP block in gynecologic laparoscopy.