bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conflicts and Global Powers in the Eastern Mediterranean. An Introduction
Authors: Axt Heinz-Jürgen 
Published: October 2022

AbstractConflicts in the Eastern Mediterranean have a long history, and recently supposed energy reserves have fuelled confrontations. Many studies are available that mainly analyse the strategies of the littoral states of the Mediterranean. This special issue enlarges the perspective by also including the global powers the EU, the United States, Russia, and China in the analysis. The role of the regional power Turkey is also in focus here. Importantly, Russia’s war against Ukraine must be taken into account. Since the Russian president has been using gas as a weapon and trying to put pressure on Europe in particular, the relevance of the energy reserves in the Eastern Mediterranean must be reassessed. After the end of the Cold War, the actors on the global political level promised a rule-based world order. This promise has been severely challenged, however, after Russia’s invasion of Ukraine which makes it necessary to reassess the relations between the global powers and the Mediterranean countries.
The Age of Reason: Functional Brain Network Development during Childhood
Authors: Tooley Ursula A. , Park Anne T. , Leonard Julia A. , Boroshok Austin L. , McDermott Cassidy L. , Tisdall Matthew D. , Bassett Dani S. , Mackey Allyson P. 
Published: October 2022

Human childhood is characterized by dramatic changes in the mind and brain. However, little is known about the large-scale intrinsic cortical network changes that occur during childhood because of methodological challenges in scanning young children. Here, we overcome this barrier by using sophisticated acquisition and analysis tools to investigate functional network development in children between the ages of 4 and 10 years (n=92; 50 female, 42 male). At multiple spatial scales, age is positively associated with brain network segregation. At the system level, age was associated with segregation of systems involved in attention from those involved in abstract cognition, and with integration among attentional and perceptual systems. Associations between age and functional connectivity are most pronounced in visual and medial prefrontal cortex, the two ends of a gradient from perceptual, externally oriented cortex to abstract, internally oriented cortex. These findings suggest that both ends of the sensory-association gradient may develop early, in contrast to the classical theories that cortical maturation proceeds from back to front, with sensory areas developing first and association areas developing last. More mature patterns of brain network architecture, controlling for age, were associated with better visuospatial reasoning abilities. Our results suggest that as cortical architecture becomes more specialized, children become more able to reason about the world and their place in it.SIGNIFICANCE STATEMENTAnthropologists have called the transition from early to middle childhood the “age of reason”, when children across cultures become more independent. We employ cutting-edge neuroimaging acquisition and analysis approaches to investigate associations between age and functional brain architecture in childhood. Age was positively associated with segregation between cortical systems that process the external world and those that process abstract phenomena like the past, future, and minds of others. Surprisingly, we observed pronounced development at both ends of the sensory-association gradient, challenging the theory that sensory areas develop first and association areas develop last. Our results open new directions for research into how brains reorganize to support rapid gains in cognitive and socioemotional skills as children reach the age of reason.
OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Oxidative stress and in vitro ageing of the post-ovulatory oocyte: an update on recent advances in the field
Authors: Martin Jacinta H , Nixon Brett , Cafe Shenae L , Aitken R John , Bromfield Elizabeth G , Lord Tessa 
Published: October 2022

In brief
Post-ovulatory ageing of oocytes leads to poor oocyte and embryo quality as well as abnormalities in offspring. This review provides an update on the contributions of oxidative stress to this process and discusses the current literature surrounding the use of antioxidant media to delay post-ovulatory oocyte ageing.

Abstract
Following ovulation, the metaphase II stage oocyte has a limited functional lifespan before succumbing to a process known as post-ovulatory oocyte ageing. This progressive demise occurs both in vivo and in vitro and is accompanied by a deterioration in oocyte quality, leading to a well-defined sequelae of reduced fertilisation rates, poor embryo quality, post-implantation errors, and abnormalities in the offspring. Although the physiological consequences of post-ovulatory oocyte ageing have largely been characterised, less is known regarding the molecular mechanisms that drive this process. This review presents an update on the established relationships between the biochemical changes exhibited by the ageing oocyte and the myriad of symptoms associated with the ageing phenotype. In doing so, we consider the molecular events that are potentially involved in orchestrating post-ovulatory ageing with a particular focus on the role of oxidative stress. We highlight the mounting evidence that oxidative stress acts as an initiator for a cascade of events that create the aged oocyte phenotype. Specifically, oxidative stress has the capacity to disrupt mitochondrial function and directly damage multiple intracellular components of the oocyte such as lipids, proteins, and DNA. Finally, this review addresses emerging strategies for delaying post-ovulatory oocyte ageing with emphasis placed on the promise afforded by the use of selected antioxidants to guide the development of media tailored for the preservation of oocyte integrity during in vitro fertilisation procedures.
Un modelo actancial para el estudio de la jurisprudencial constitucional en Colombia: una mirada desde cuatro derechos fundamentales de la población privada de la libertad
Authors: Navajas Barrera Diego Alain 
Published: October 2022

La jurisprudencia constitucional en Colombia es principalmente analizada mediante el uso de técnicas de análisis jurisprudenciales tradicionales que se basan en el estudio del precedente judicial para tres fines particulares: la aplicación del derecho en casos concretos, la interpretación de disposiciones legales, y suplir vacíos normativos en ausencia de legislación. De otro lado, es poco común el estudio de la jurisprudencia desde otras técnicas de análisis cualitativo de datos. Es en ese sentido que, los avances de investigación presentados en este artículo intentan mostrar cómo estudiar la jurisprudencia constitucional desde un enfoque semiótico haciendo uso de la herramienta analítica de los modelos actanciales.
Concretamente se busca aplicar el modelo actancial de A.J. Greimas sobre la jurisprudencia constitucional de cuatro derechos fundamentales de la población privada de la libertad en Colombia: derecho a la unidad familiar, a la libertad religiosa y de cultos, a la libertad sexual-visita íntima y derecho al trabajo penitenciario. Para finalmente obtener una estructura actancial que dé cuenta de los elementos narratológicos presentes en las sentencias judiciales cuando estas son estudiadas desde la semiótica como un relato narrativo.
Understanding the Impact of Belzutifan on Treatment Strategies for Patients with VHL
Authors: Arevalo Aileen , Patel Neal , Muraki Peter , Ohtake Shinji , Bratslavsky Gennady , Clark Chandra , Mann Joshua , Iliopoulos Othon , Jonasch Eric , Srinivasan Ramaprasad , Shuch Brian 
Published: October 2022

Belzutifan was recently approved for the management of Von Hippel–Lindau disease (VHL). Given the morbidity of recurrent treatment, systemic therapy to reduce or eliminate the need for surgery has been long-awaited. Herein, we sought to gain insight about future utilization by surveying VHL experts in the United States. A survey developed by members of the VHL Alliance (VHLA) Clinical Advisory Council was distributed to kidney cancer providers at VHLA and National Comprehensive Cancer Network (NCCN) centers. Surveys were administered on a secure web-based platform. A total of 60 respondents from 29 institutions participated. Urologists (50%) and medical oncologists (43%) represented the majority of participants. The majority (98%) of respondents anticipated that belzutifan’s approval would signifi-cantly change the current treatment landscape. Most reported that therapy should be continuous (76%). There was a difference in willingness to prescribe belzutifan by specialty (38% of urologists vs 91% of medical oncologists (P = 0.02). In individuals with renal tumors <3 cm, 36% would still recommend surveillance, while 36% would initiate belzutifan to prevent growth. In those with multifocal renal lesions and growth of a solitary tumor on belzutifan, 50% would proceed with only treatment of that site. In conclusion, VHL kidney cancer specialists anticipate a paradigm shift with the approval of belzutifan. Provider roles may change with movement away from surgical management. Opinions on treatment indications, such as when to initiate therapy and how to best salvage, vary widely and collaborative efforts among experts may assist in the development of clinical guidelines.
POTENTIAL OF USING SACCHAROMYCES BOULARDII TO PRODUCE FERMENTED MILK PRODUCTS
Authors: Khablenko A. , Danylenko S. , Yalovenko O. , Duhan O. , Potemskaia O. 
Published: October 2022

The analysis of the literature allows us to characterise the potential of the new probiotic yeast strain S. boulardii. The paper describes the long period of formation of fundamental knowledge and introduction of some technological methods into the production of different fermented milks products. Besides the historical aspect, the microbiological diversity of fermented milks products is considered, and the technological differences in manufacturing them are shown. It is known that yoghurt is one of the most famous fermented milk products. This dairy product has been very popular for years due to its taste characteristics and ease of manufacture. With the accumulation of knowledge about probiotics and the yoghurt production technology, there has appeared a tendency to further enrichment of the product with certain probiotics, prebiotics, and minerals. Today, yoghurt manufacturing actively uses the method of enriching the finished product with probiotics. This allows creating a qualitatively new functional food product that not only has nutritional value for the consumer, but also produces a certain positive effect on intestinal microbes and thus on the consumer’s health. Bacteria are known to be the main probiotics, but the recent discovery of the probiotic properties of certain genera and species of yeast opens up new prospects of their use, both in the pharmaceutical industry and in creating functional foods. The recently discovered yeast strain S. boulardii, phylogenetically related to S. cerevisiae, has many therapeutic effects and significant advantages over bacterial probiotics, in particular, it is resistant to antibiotics. S. boulardii is a probiotic strain that can be used to enrich yoghurt. The physiological properties of the strain and therapeutic properties of the products of its metabolism along with the technological parameters of yoghurt processing make a combination of the probiotic and this beneficial fermented milk very promising. It has been determined that to produce enriched yoghurt, it is possible to use both a lyophilised culture of S. boulardii and a microencapsulated one. On analysing the economic aspect, especially the sale of yoghurts and the further tendency towards an increase in its consumption, we can say that the introduction of S. boulardii as an enrichment strain is a promising issue of current importance.
Interação entre políticas públicas e dinâmicas locais da agricultura familiar no Território do Portal da Amazônia - Mato Grosso
Authors: Sabourin Eric , Rodrigues José Alesando , Caron Patrick 
Published: October 2022

A agricultura familiar representa um dos principais grupos sociais e econômicos no norte do Mato Grosso. Entender a interação entre as políticas públicas e as dinâmicas locais e regionais que afetam esse setor econômico é de fundamental importância para identificar as lacunas e os problemas de ordem política e operacional que dificultam o desenvolvimento da região. Este estudo visa analisar o impacto local e a apropriação das políticas públicas relacionadas ao desenvolvimento rural pela produção familiar e por atores sociais do território denominado Portal da Amazônia, que abrange 16 municípios situados no norte de Mato Grosso. Para tal foram comparados os instrumentos clássicos de política pública para a produção familiar (políticas de crédito, assistência técnica e extensão rural e apoio à valorização econômica ou à qualificação dos produtos), com novos instrumentos participativos de políticas públicas (programas do governo federal que valorizam a gestão ambiental e a produção sustentável). Esses dois grupos de políticas públicas se diferenciam principalmente pela escala de atuação: o primeiro tem cunho mais individual, associado ao dono do lote, e o segundo tem abrangência territorial, aplicado a um grupo de municípios. Os resultados demonstram uma aplicação problemática e deficiente dos instrumentos clássicos, em particular o crédito e a assistência técnica, o que dificulta a gestão ambiental e incentiva práticas produtivas pouco sustentáveis, embora com um potencial de diversificação da assistência técnica e extensão rural (ATER). Os novos instrumentos de políticas públicas com base no território, como o Vida Rural Sustentável têm proporcionado espaços importantes de inovação e organização dos agricultores, assim como uma maior interação com a sociedade civil local. Esses novos instrumentos têm fortalecido o reconhecimento e a importância da produção familiar para a economia da região, incentivando a mesma a buscar a melhoria de sua produção. Uma produção familiar fortalecida, organizada e atuando de forma coletiva é fundamental para a promoção de um desenvolvimento rural que seja baseado na produção sustentável, que respeite o meio ambiente e propicie uma distribuição de renda mais igualitária.
Inteligencia Nacional Argentina: funcionalidad y presupuesto. Sus impactos en la cultura de inteligencia (1989-2022)
Authors: Vitti Jorge Gabriel 
Published: October 2022

La inteligencia, una herramienta indispensable para la toma de decisiones estratégicas, no es visualizada por amplios sectores de la sociedad argentina como una actividad con la importancia y orientación citada. Este artículo explora algunos de los basamentos más importantes de la ausencia de la cultura de inteligencia, en un período significativo por la gravedad de los sucesos que ocurrieron en él, para determinar la existencia de bases normativas y su correcta aplicación en situaciones concretas. Se analizan dos de los aspectos más significativos de la cultura de inteligencia, revisando tanto la doctrina como las regulaciones, su aplicación e impacto: su función pública, íntimamente relacionada con la percepción de la utilidad y eficacia de sus servicios; y la asignación y el uso de gastos de presupuesto reservados. Finalmente, se presentan conclusiones y estrategias para la construcción de una cultura de inteligencia nacional, en el marco de un estado de derecho.
Abstract
Intelligence is an indispensable tool for making strategic decisions. However, it is not perceived as such by broad sectors of Argentinian society. This work explores some of the most important foundations of the absence of intelligence culture, in a relevant period due to several serious events, to determine the existence of normative bases and their correct application in specific situations. To this end, the most significant aspects of that vision are explored, delving into both the doctrine and the regulations, as well as their application and impact: its public function, closely related to the perception of the usefulness and effectiveness of its services; and the allocation and use of earmarked budget expenses. Finally, conclusions and strategies for the construction of a culture of national intelligence, within the framework of a rule of law are presented.
Enemigos internos e institucionalidad de inteligencia fuerte: León Febres Cordero y Rafael Correa Delgado
Authors: Piedra Cobo Lorena Yael 
Published: October 2022

En este artículo se describen y comparan la estructura y la directiva de trabajo de la función de inteligencia en Ecuador en las gestiones presidenciales de León Febres Cordero y Rafael Correa Delgado. Al comparar dos periodos que institucionalizaron fuertemente la función de inteligencia ecuatoriana, el objetivo es dar cuenta sistemáticamente de sus similitudes y diferencias. A través de una metodología de base comparativa, limitada por la clasificación de las fuentes primarias, característica del estudio de los sistemas de inteligencia, se trabaja desde una perspectiva institucionalista, que supera la esfera normativa e incluye el análisis de prácticas no declaradas. Se concluye que los periodos analizados coinciden en una fuerte capacidad de determinación de la agenda por parte del ejecutivo, que por distintos motivos se enfocó en enemigos internos. Además, bajo un marco legal incapaz de establecer controles horizontales a la actividad. Por otro lado, las diferencias encontradas residen en el aspecto económico y en el beneficiario directo de la agenda de trabajo.
Abstract
The following analysis describes and compares the structure and mainframe directions of the intelligence function in Ecuador during the presidential administrations of Leon Febres Cordero and Rafael Correa Delgado. By comparing these two periods that strongly institutionalized the Ecuadorian intelligence function, the objective is to systematically account for their similarities and differences. Through a comparative-based methodology, limited by the classification of primary sources, characteristic in the study of intelligence systems, an institutionalist perspective is used, which goes beyond the normative sphere, and includes the analysis of non-declared practices. It is concluded that those analyzed periods coincide in a strong ability to determine the agenda by the executive branch, that for different reasons focused on internal enemies. In addition, in a legal framework incapable of establishing horizontal controls on the activity. On the other hand, the differences found reside in the economic aspect and in the direct beneficiary of the work agenda.
Turkish Validity and Reliability of the Satisfaction with Simulation Experience Scale
Authors: TÜZER Hilal , KOCATEPE Vildan , YILMAZER Tuba , İNKAYA Bahar , ÜNVER Vesile , LEVETT-JONES Tracy 
Published: October 2022

Objective: Research on simulation-based experience focuses primarily on the student's level of knowledge, skills, self-confidence, and satisfaction. There is only one scale in Turkish that can be used to measure satisfaction with the simulation experience. The aim of this study was to establish the validity and reliability of the Turkish version of the Satisfaction with Simulation Experience Scale (SSES).
Methods: The study sample consisted of 130 nursing students from two universities. Data were collected using a student information form, the Turkish version of the Satisfaction with Simulation Experience Scale (SSES-TR) and the Scale of Student Satisfaction and Confidence in Learning (SSSCL). The original SSES was translated into Turkish. Thirteen academics, who were experts in nursing and simulation, were consulted for content validity. Expert feedback was collected in a form to determine the content validity ratio using Lawshe's technique. The Turkish adaptation of the SSES was performed by four linguists to ensure linguistic validity. The correlation between the SSES-TR and SSSCL was determined using concurrent validity and Pearson’s Correlation. Internal consistency tests were used to test reliability. The SSES-TR was administered to 35 students as a test-retest with an interval of two weeks to determine its consistency across time. Construct validity was evaluated by confirmatory factor analysis (CFA).
Results: The scale had a content validity index (CVI) of 0.86. The SSES-TR had a Cronbach’s alpha (α) of 0.928. The correlation between SSES-TR items and total and subscale scores ranged from 0.492 to 0.749. Test-retest reliability coefficients showed that the SSES-TR total score and subscale scores were compatible. The fit statistics of the 3-factor scale structure according to CFA are at the level of "acceptable fit" according to RMSEA (0.095) and SRMR (0.090).
Conclusions: The SSES-TR is a reliable and valid measure that can be used to assess nursing students’ satisfaction with simulation-based experience.
Correlation Between Heat Stress With Dehydration Incident Among Outdoor Workers at Parking Area and Security in a Private Hospital in Palembang
Authors: Artanto Ardi , Putra Gunawan Ernes , Luthfiyah Fadilah Dennisa 
Published: October 2022

: A combination of metabolic heat and environmental variables causes heat stress (air temperature, humidity, air flow rate, heat radiation temperature). Sweating is induced by fluid loss through evaporation in response to heat stress. Dehydration can occur if the conditions of loss or loss of water or excessive bodily fluids and fluid intake are not restored, which can have an influence on the occupational health of outdoor workers. Analytic observational study was conducted using a Cross Sectional Study technique. All of the participants in this study were outdoor workers at parking area and security guards at a private hospital in Palembang. Using the total sampling approach, 46 samples were acquired that fulfilled the inclusion criteria but did not match the exclusion requirements. 43.5 percent of outdoor employees were exposed to heat stress. The results showed that 67.4 percent were dehydrated and 32.6 percent were not dehydrated. With a p-value of 0.009 (P<0.05), there is a significant correlation between heat stress and incidence of dehydration in outdoor workers in the parking and security departments of a private hospital in Palembang city.
The Strategy Development of Marine Posture in Supporting the Main Task of Navy Using Swot and Borda Method
Authors: Syahtaria Mohamad Ikhwan 
Published: October 2022

The Unitary State of the Republic of Indonesia is the largest archipelago country in the world. Its geological constellations which is the world cross position, place the marine territory of the national jurisdiction very strategically for Indonesia as well as for other countries. The marine posture capability can still be developed by enhancing the power and ability of the marines and optimizing the degree patterns. The marine posture development strategy can be done by learning the potential possible threats in the future and analyzing the marine posture conditions that must be improved to enhance national marine security. In this research, the strategy was analyzed with SWOT and BORDA methods. The result of this research is IFE value is 3.26 (3.00- 4.00) and the EFE value of 3.21 (3.00 – 4.00) which indicates that the marine posture is currently in a strong position. The position of marine posture strategy located at coordinates (3.26; 3.21) is Growth and Build. The marine posture development strategy lies in the position of quadrant III with coordinates (0.02;-0.11) that indicate st (strength threat) strategy, i.e. marine posture utilizes force to overcome threats.