bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish
Authors: Wasserman-Bartov Talya , Admati Inbal , Lebenthal-Loinger Ilana , Sharabany Julia , Lerer-Goldshtein Tali , Appelbaum Lior 
Published: September 2022

Thyroid hormones (THs), thyroxine (T4), and triiodothyronine (T3), regulate growth, metabolism, and neurodevelopment. THs secretion is controlled by the pituitary thyroid-stimulating hormone (TSH) and the hypothalamic–pituitary–thyroid (HPT) axis. The organic anion-transporting polypeptide 1C1 (OATP1C1/SLCO1C1) and the monocarboxylate transporter 8 (MCT8/SLC16A2) actively transport THs, which bind to their nuclear receptors and induce gene expression. A mutation inOATP1C1is associated with brain hypometabolism, gradual neurodegeneration, and impaired cognitive and motor functioning in adolescent patients. To understand the role of Oatp1c1 and the mechanisms of the disease, we profiled the transcriptome ofoatp1c1mutant (oatp1c1−/−) andmct8−/−xoatp1c1−/−adult male and female zebrafish brains. Among dozens of differentially expressed genes, agouti-related neuropeptide 1 (agrp1) expression increased inoatp1c1−/−adult brains. Imaging in the hypothalamus revealed enhanced proliferation of Agrp1 neurons inoatp1c1−/−larvae and adults, and increased food consumption inoatp1c1−/−larvae. Similarly, feeding and the number of Agrp1 neurons increased in thyroid gland-ablated zebrafish. Pharmacological treatments showed that the T3 analog TRIAC (3,3′,5-tri-iodothyroacetic acid), but not T4, normalized the number of Agrp1 neurons inoatp1c1−/−zebrafish. Since the HPT axis is hyperactive in theoatp1c1−/−brain, we used the CRISPR-Cas9 system to knockdowntshinoatp1c1−/−larvae, and inducibly enhanced the HPT axis in wild-type larvae. These manipulations showed that Tsh promotes proliferation of Agrp1 neurons and increases food consumption in zebrafish. The results revealed upregulation of both the HPT axis–Agrp1 circuitry and feeding in a zebrafish model for OATP1C1 deficiency.SIGNIFICANCE STATEMENTMutation in the thyroid hormone (TH) transporterOATP1C1is associated with cognitive and motor functioning disturbances in humans. Here, we used anoatp1c1−/−zebrafish to understand the role of organic anion-transporting polypeptide 1C1 (Oatp1c1), and the characteristics of OATP1C1 deficiency. Transcriptome profiling identified upregulation ofagrp1expression in theoatp1c1−/−brain. Theoatp1c1−/−larvae showed increased thyroid-stimulating hormone (tsh) levels, proliferation of Agrp1 neurons and food consumption. Genetic manipulations of the hypothalamic–pituitary–thyroid (HPT) axis showed that Tsh increases the number of Agrp1 neurons and food consumption. The T3 analog TRIAC (3,3′,5-tri-iodothyroacetic acid) normalizes the number of Agrp1 neurons and may have potential for the treatment of Oatp1c1 deficiency. The findings demonstrate a functional interaction between the thyroid and feeding systems in the brain of zebrafish and suggest a neuroendocrinological mechanism for OATP1C1 deficiency.
Integrating Visual Information into the Auditory Cortex Promotes Sound Discrimination through Choice-Related Multisensory Integration
Authors: Chang Song , Xu Jinghong , Zheng Mengyao , Keniston Les , Zhou Xiaoming , Zhang Jiping , Yu Liping 
Published: September 2022

An increasing number of studies have shown that cross-modal interaction can occur in early sensory cortices. Yet, how neurons in sensory cortices integrate multisensory cues in perceptual tasks and to what extent this influences behavior is largely unclear. To investigate, we examined visual modulation of auditory responses in the primary auditory cortex (A1) in a two-alternative forced-choice task. During the task, male rats were required to make a behavioral choice based on the pure tone frequency (low vs high) of the self-triggered stimulus to get a water reward. The result showed that the presence of a noninformative visual cue did not uniformly influence auditory response, with frequently enhancing just one of them. Closely correlated with behavioral choice, the visual cue mainly enhanced responsiveness to the auditory cue indicating a movement direction contralateral to A1 being recorded. Operating in this fashion provided A1 neurons a superior capability to discriminate sound during multisensory trials. Concomitantly, behavioral data and decoding analysis revealed that visual cue presence could speed the process of sound discrimination. We also observed this differential multisensory integration effect in well-trained rats when tested with passive stimulation and under anesthesia, albeit to a much lesser extent. We did not see this differentially integrative effect while recording in A1 in another similar group of rats performing a free-choice task. These data suggest that auditory cortex can engage in meaningful audiovisual processing, and perceptual learning can modify its multisensory integration mechanism to meet task requirements.SIGNIFICANCE STATEMENTIn the natural environment, visual stimuli are frequently accompanied by auditory cues. Although multisensory integration has traditionally been seen as a feature of associational cortices, recent studies have shown that cross-modal inputs can also influence neuronal activity in primary sensory cortices. However, exactly how neurons in sensory cortices integrate multisensory cues to guide behavioral choice is still unclear. Here, we describe a novel model of multisensory integration used by A1 neurons to shape auditory representations when rats performed a cue-guided task. We found that a task-irrelevant visual cue could specifically enhance the response of neurons in sound guiding to the contralateral choice. This differentially integrative model facilitated sound discrimination and behavioral choice. This result indicates that task engagement can modulate multisensory integration.
The Philosophy of Sport and Physical Education: Four Decade Publication Trends via Scientometric Evaluation
Authors: Sofyan Davi , Abdullah Khairul Hafezad , Hafiar Hanny 
Published: September 2022

The study purpose was to look into the production of scientific publications on the Philosophy of Sports and Physical Education.
Materials and methods. Scopus and Web of Science databases and various bibliometric indicators such as global publication trends, most active authors, number of citations, and author keywords were used to collect publications.
Results. A total of 1103 publications on the philosophy of sport and physical education were found from 1981 to 2021. This review used data in comma-separated values (CSV) format for Scopus, which was then exported to Microsoft Excel and text documents in WoS format, as well as ScientoPy software. The research findings provide information that, from 1981 to 2021, publications experienced a fluctuating trend in quantity. Starting in 2016, publications have reached double digits, with the number of publications reaching 71 documents. The United States is listed as the most productive country with a number of published documents as high as 226 academic scientific works. Ryall, E., University of Gloucestershire, United Kingdom, became the most prolific author with a total of 33 publications. The Department of Philosophy in the United States is at the forefront of publications with 39 documents.
Conclusions. A number of limitations in this study are unavoidable. First, the research method used by researchers is not completely perfect, including how to find documents, categorize documents, and document provider databases, which cannot be ignored. Researchers believe that this scientometric research provides important information about future research directions in the philosophy of sport and physical education.
Determining the Near-Future Biocomfort Zones in Samsun Province by the Global Climate Change Scenarios
Authors: KOÇ İsmail 
Published: September 2022

Aim of study: This study aimed to determine the current and future (present, 2040, 2060, 2080) climate changes in the study area within the scope of climate change scenarios (SSPs 245 and SSPs 585) of the Coupled Model Intercomparison Project.
Area of study: The study area is Samsun province.
Material and methods: The current climate data were obtained from the measurements performed by 24 meteorology stations. Using the measurement data of the period 2000-2020 obtained from these data, the climate maps were prepared with the “Inverse Distance Weighted” method were used for this study. The biocomfort index formulas were applied to these maps, and biocomfort maps were obtained.
Main results: Today’s average minimum and maximum temperature changes around 7-24 °C in the area. According to the two scenarios, the temperature will change between 13-19 °C from 2040 to 2080 and then stay constant in the first scenario while it will increase up to 19-25 °C in the second scenario during 2080-2100. As a result, the area will have much warmer, and there might be warm zones in Samsun in 2100.
Highlights: The biocomfort zones in Samsun province would remarkably change soon, especially the cooling costs, and will negatively contribute to global climate change due to energy consumption and gases used by air-conditioning systems.
Risk factors for surgical site infection following craniotomy: a 10-year retrospective cohort study
Authors: Rowbottom Hojka , Hribernik Borut , Ravnik Janez 
Published: September 2022

Namen: Kraniotomija je osnovni nevrokirurški pristop, ki je povezan z zapleti, med katere spada okužba kirurške rane, za pojav katere so dejavniki tveganja še vedno nepopolno definirani. Namen raziskave je bil prepoznati dejavnike tveganja za pojav okužbe kirurške rane pri odraslih bolnikih, operiranih na Oddelku za nevrokirurgijo Univerzitetnega kliničnega centra v Mariboru.
Metode: Izvedli smo retrospektivno kohortno študijo, v kateri smo analizirali podatke za obdobje od januarja 2009 do avgusta 2019. Primerjali smo podatke bolnikov, ki so razvili okužbo kirurške rane, s podatki tistih, ki okužbe niso razvili. 66 bolnikov je razvilo okužbo kirurške rane, v kontrolno skupino smo naključno uvrstili 70 bolnikov brez omenjene rane. V raziskavo smo vključili le bolnike, ki so po opravljeni elektivni kraniotomiji potrebovali kirurško zdravljenje okužene kirurške rane.
Rezultati: Med 1192 bolniki, ki so v opazovanem obdobju imeli opravljeno kraniotomijo, je 66 (5,5 %) bolnikov razvilo okužbo kirurške rane. Najpogosteje je prišlo do razvoja osteomielitisa (66,7 %) in epiduralnega abscesa (63,6 %), najpogosteje izoliran povzročitelj pa je bil Propionibacterium acnes (54,5 %). V raziskavi so se kot dejavniki, povezani s pojavom okužbe kirurške rane, izkazali uporaba izdelka Surgicel® (p = 0,0019, Fisherjev natančni test), duralni nadomestki (p = 0,0028, Fisherjev natančni test), samolepilna dura (p = 0,0274, Fisherjev natančni test), zapiranje kože s šivi (p = 0,0001, Fisherjev natančni test), opravljena frontalna kraniotomija (p = 0,0328, Fisherjev natančni test) in pooperativno predpisovanje glukokortikoidov (p = 0,04, Fisherjev natančni test).
Zaključek: Z našo študijo smo prepoznali določene dejavnike tveganja, povezane s pojavi okužbe kirurške rane, ki jih lahko odpravimo in tako znižamo pojavnost tovrstnega operativnega zapleta oz. zaplet hitreje prepoznamo.
Hookworm in Stray Cats (Felis silvestris catus) as Cutaneous Larva Migrant Agent (CLM) in Humans
Authors: Mahendra Fadhil Ihsan , Soebaktiningsih Soebaktiningsih , Prabawati Risma Karlina 
Published: September 2022

Highlights :

Risk factors that can increase the incidence of CLM in humans include male sex, children aged <15 years, low-income people, and daily behaviour of walking outdoors without using footwear, especially on the sand.
Risk factors that play the most role in increasing the incidence of CLM in humans are walking outdoors without using footwear, especially on the sand.

Abstract :
Cats arethe host of a wide variety of microorganisms including ectoparasites and endoparasites.One of theendoparasites that infect cats is hookworm. The hookworms consists of two groups, the animal hookworms, and the human hookworms. The manifestation that can be caused by animal hookworms to humans is Cutaneous Larva Migrant (CLM). This study aimed to discover whether hookworm in stray cats (Felis silvestris catus) can cause CLM in humans. We performed a systematic search in Pubmed/Medline and Cochrane published between 2016 and 2021 with no restrictions by language, research country, or type of research design . The results of the analysis showed that the high level of hookworms infection in stray cats could increase the risk of CLM in humans. Based on the study, we could conclude that the high prevalence of hookworm infection in cats plays an important role in the increased risk of zoonoses in humans which in turn could also increase the prevalence of CLM in humans.
Bacterial and Antibiogram Profile of Urinary Tract Infection Patients in Tertiary Hospital, Surabaya, Indonesia
Authors: Utami Mahrumi Dewi Tri , Wahyunitisari Manik Retno , Mardiana Nunuk , Setiabudi Rebekah Juniati 
Published: September 2022

Highlights:

Most urinary tract infections are caused by Gram-negative bacteria with E. coli being the most common bacteria.
Antibiotics with the highest susceptibility for Gram-negative bacteria were ertapenem, meropenem, amikacin, and imipenem.
Antibiotics with the highest susceptibility for Gram-positive bacteria mainly were susceptible to chloramphenicol,streptomycin, vancomycin, rifampin, tigecycline, teicoplanin, and ampicillin.

Abstract:
Urinary tract infection (UTI) is one of the most common bacterial infections. Inappropriate antibiotic use for UTI treatment may lead to antibiotic resistance. This study aimed to provide an updated bacterial and antibiogram profile from urine specimens of patients diagnosed with UTI. This study was a retrospective study using urine culture and antibiotic susceptibility test results obtained from Clinical Microbiology Laboratory in a tertiary general hospital in Surabaya, Indonesia for a two-month period patients. Most aged more than and/or equal to 59 years, in both sexes. Gram-negative bacteria, particularly , was being the most between June to July 2019. There were 215 patients with significant urine culture results of 54.4% from Escherichia coli female bacteria were carbapenem antibiotics and amikacin, while teicoplanin and vancomycin were some antibiotics susceptible to gramcommon bacteria that caused UTI, followed by K. pneumoniae. Some antibiotics with the highest susceptibility to gram-negative positive bacteria. This study result indicated that there was an urge to conduct local antibiogram profile investigation due to the low susceptibilities shown in recent empirical therapy recommendations, such as trimethoprim sulfamethoxazole, fluoroquinolone, nitrofurantoin, and fosfomycin.
Vascular Dementia Patients Characteristics With a History of Stroke in a National Brain Center Hospital Jakarta, Indonesia
Authors: Hanifah Afifah Kusuma , Astari Riezky Valentina , Muktamiroh Hikmah , Saleh Arman Yurisaldi 
Published: September 2022

Highlights:

Characteristics of vascular dementia patients with a history of stroke was aimed.
The most characteristics of vascular dementia patients with stroke history are men, post-ischemic stroke, hypertension grade 1, and lesions in the basal ganglia.

Abstract:
Stroke patients increase each year. Stroke is a cerebrovascular disorder caused by disruption of cerebral blood flow, which could reason vascular lesions within the mind parenchyma to be a threat to significant disorders. One of them is vascular dementia. Each affected person is prone to growing dementia after a stroke in three to five instances. Thisstudy aimed to decide the traits of patients with vascular dementia with a record of stroke. This study used a descriptive retrospective approach with a cross-sectional method. The samples were obtained from the total sampling technique. The sample of the study was vascular dementia patients with a stroke record at the National Brain Center Hospital Prof. Dr. dr. Mahar Mardjono Jakarta in the period of 2020 through the inclusion standards with 191 samples. This study found that the majority of patients were males as many as 129 (67.5%), age group of 55-64 were 67 patients (35.1%), post-ischemic strokes were 164 patients (85.9%), grade 1 hypertension as many as 70 patients (36.6%), and basal ganglia as many as 76 patients (29.23%). Characteristics of vascular dementia patients with the maximum stroke records in men, aged 55-64 years, post-ischemic stroke, grade 1 hypertension, and a majority of the lesions within the basal ganglia.
Knowledge on The Risk of The Ischemic Heart Disease Estimation by WHO Charts in Cempaka Baru, Indonesia
Authors: Fitriani Hasna Luthfiah , DA Ridwan Karina Ajeng 
Published: September 2022

Highlights:

The risk estimation of ischemic heart disease.
High blood pressure and cholesterol levels affect Ischemic heart disease.

Abstract:
In 2018, Indonesia became the country with the second-highest number of deaths and disabilities (DALYs) due to ischemic heart disease. Based on Riskesdas data in 2018, Jakarta is one of the provinces with a high percentage (1.9%) of ischemic heart disease. Risk factors for ischemic heart disease that are not treated quickly will increase the severity of ischemic heart disease in the future. Therefore, this study was to provide education regarding the assessment of risk estimation for ischemic heart disease with WHO/ISH charts among participants in Cempaka Baru sub-district. This study used pre-test and post-test questionnaires. After the seminars, the interview and examination results were carried out as well as calculating the estimated risk of ischemic heart disease using the WHO chart. These charts were divided into low risk (<10%), moderate (10-20%), and severe (>20%). The evaluation was conducted by comparing the pre-test and post-test results, which indicated that the knowledge level increased significantly from the Paired T-Test with a p-value = 0.000 (p<0.05). The significant estimation of high risk of ischemic heart disease for high blood pressure was 72.7% (p=0.023) and total cholesterol level was 66.7% (p=0.049). The increasing knowledge of the stratification risk of ischemic heart disease with the WHO chart was expected to reduce the risk of ischemic heart disease in the future.
Risk Factors of Central Obesity in Indonesian Men: A Cross-Sectional Data Study of The Indonesia Family Life Survey 5 (IFLS 5)
Authors: Dahlia  , Pribadi Gracia Satyawestri , Martini Santi , Yi-Li Chung 
Published: September 2022

Highlights:

Low levels o physical activity are the major risk factor of central obesity among Indonesian men.
There was a relationship between smoking status, smoker type, cigarette type, physical activity, and meat consumption frequency and the incidence of central obesity.

Abstract:
Obesity is one of the leading health problems in both developed and developing countries. Central obesity can be defined as a condition where excess fat has accumulated in the abdominal area. There are several risk factors that may cause central obesity in men such as smoking habits, physical activity, and dietary habits. This study aimed to analyse the risk factors of central obesity in Indonesian men. This was an analytical observational study using a cross-sectional design. It used secondary data from the Indonesia Family Life Survey (IFLS 5) with a sample size of 4,648 respondents. The variables studied here were smoking status, type of smoker, type of cigarette, physical activity, and meat consumption frequency. Logistic regression analysis was used. The results of this study showed that the mean age of the respondents was 51 years old. There was a relationship between smoking status (p=0.000), type of smoker (p=0.002), type of cigarette (p=0.000), physical activity (p=0.000), and meat consumption frequency (p=0.024) and the incidence of central obesity. The conclusion of the study was that there was a relationship between smoking status, type of smoker, type of cigarette, physical activity, meat consumption frequency, and the incidence of central obesity, all of which were risk factors of central obesity in Indonesian men. A low level of physical activity was the most prominent risk factor associated with central obesity among Indonesian men. From this study, we suggested controlling the risk factors of central obesity by providing education on the dangers of smoking and the importance of physical activity and a balanced nutritional diet.
Durability of S-RBD IgG Antibody Levels after Sinovac Vaccination in Healthcare Workers
Authors: Nugraha Jusak , Permatasari Cynthia Ayu , Fitriah Munawaroh 
Published: September 2022

Highlights:

The effectiveness of vaccination through the kinetics of the antibody response to the SARS-COV-2 vaccine administration by examining IgG S-RBD levels was aimed.
Two doses of the Sinovac vaccine formed antibodies in healthy individuals in the first 3rd month after vaccination.
An S-RBD IgG antibody in the 6th-month post-vaccination was significantly different between groups without a history and groups with a history of infection with COVID-19.

Abstract:
Since it was declared a pandemic in early 2020, Coronavirus Disease 2019 (Covid-19) has caused high morbidity and mortality in the world. In view of the urgency of the situation, vaccination efforts are needed to break the chain of disease transmission. Various types of vaccines have been successfully developed and obtained approval for emergency use. However, the effectiveness of these vaccines, both in the short and long term, has not been fully known. This study aimed to examine the effectiveness of vaccination through the kinetics of the antibody response to the administration of the SARS-COV-2 vaccine by examining IgG S-RBD levels. This study was an observational analytic study with a prospective cohort approach carried out between January and November 2021 at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Fifty health workers who received Sinovac vaccination in as many as 2 doses underwent venous blood taking and measurement of quantitative S-RBD antibody level. Then, quantitative S-RBD IgG antibody levels were measured and recorded in each subject. The mean S-RBD IgG antibody was found to have fluctuation. The titer was found to significantly increase on day 14 and dropped significantly in month 3 (p <0.001). There was a significant difference in S-RBD IgG levels 6 months after vaccination between Covid-19 uninfected groups and Covid-19 infected groups (p <0.001). In a conclusion, two doses of the Sinovac vaccine formed antibodies, although humoral immunity obtained tended to decrease in 3rd month after vaccination to healthy individuals. The average level of S-RBD IgG antibody in the sixth month post-vaccination was found to be significantly different between groups without history and groups with a history of with infection COVID-19.