bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parcellation‐based tractographic modeling of the salience network through meta‐analysis
Authors: Briggs Robert G. , Young Isabella M. , Dadario Nicholas B. , Fonseka R. Dineth , Hormovas Jorge , Allan Parker , Larsen Micah L. , Lin Yueh‐Hsin , Tanglay Onur , Maxwell B. David , Conner Andrew K. , Stafford Jordan F. , Glenn Chad A. , Teo Charles , Sughrue Michael E. 
Published: June 2022

AbstractBackgroundThe salience network (SN) is a transitory mediator between active and passive states of mind. Multiple cortical areas, including the opercular, insular, and cingulate cortices have been linked in this processing, though knowledge of network connectivity has been devoid of structural specificity.ObjectiveThe current study sought to create an anatomically specific connectivity model of the neural substrates involved in the salience network.MethodsA literature search of PubMed and BrainMap Sleuth was conducted for resting‐state and task‐based fMRI studies relevant to the salience network according to PRISMA guidelines. Publicly available meta‐analytic software was utilized to extract relevant fMRI data for the creation of an activation likelihood estimation (ALE) map and relevant parcellations from the human connectome project overlapping with the ALE data were identified for inclusion in our SN model. DSI‐based fiber tractography was then performed on publicaly available data from healthy subjects to determine the structural connections between cortical parcellations comprising the network.ResultsNine cortical regions were found to comprise the salience network: areas AVI (anterior ventral insula), MI (middle insula), FOP4 (frontal operculum 4), FOP5 (frontal operculum 5), a24pr (anterior 24 prime), a32pr (anterior 32 prime), p32pr (posterior 32 prime), and SCEF (supplementary and cingulate eye field), and 46. The frontal aslant tract was found to connect the opercular‐insular cluster to the middle cingulate clusters of the network, while mostly short U‐fibers connected adjacent nodes of the network.ConclusionHere we provide an anatomically specific connectivity model of the neural substrates involved in the salience network. These results may serve as an empiric basis for clinical translation in this region and for future study which seeks to expand our understanding of how specific neural substrates are involved in salience processing and guide subsequent human behavior.
Sequential posterior interosseous artery perforator flap for reconstruction of dorsal hand defects
Authors: Zhou Xiao , Hu Deqing , Lu Hao , Tao Xianyao , Chen Peng , Wen Fuli , Xue Laien , Hong Xu , Zheng Heping 
Published: June 2022

AbstractDorsal hand defects accompanied by exposure of bones and tendons remain a huge challenge for plastic surgeons. The pedicled perforator flaps have unique advantages in resurfacing the defects. This study aimed to investigate the clinical efficacy of the sequential posterior interosseous artery perforator flap for repairing dorsal hand defects. This study was composed of an anatomical study and clinical application. Anatomically, 30 adult upper limb specimens injected with red latex were dissected, the perforators from the branches of the posterior interosseous artery were observed in the dorsal forearm, and the sequential flap based on them was designed based on the anatomical characteristics. Clinically, nine cases of soft tissue defects on the dorsum of the hand were treated by this flap. Anatomically, the posterior interosseous artery divided into an ascending branch and a descending branch, and the descending branch traveled 1.0 ± 0.3 cm down to divide into the ulnar and radial terminal branches. The ulnar terminal branch presented constantly, and the radial terminal branch had an occurrence rate of 93.33%. Clinically, all flaps survived completely and possessed a soft texture and satisfactory appearance, as well as a nonbloated pedicle, and the donor region had a natural color and appearance with only a linear scar left behind. The sequential posterior interosseous artery perforator flap could become a useful option for repairing dorsal hand defects, as it has the advantages of being easy to perform without sacrificing the main vessels and avoiding donor area skin grafting.
Concordance of breast cancer biomarker testing in core needle biopsy and surgical specimens: A single institution experience
Authors: Slostad Jessica A. , Yun Nicole K. , Schad Aimee E. , Warrior Surbhi , Fogg Louis F. , Rao Ruta 
Published: June 2022

AbstractBackgroundAccurate diagnostic biomarker testing is crucial to treatment decisions in breast cancer. Biomarker testing is performed on core needle biopsies (CNB) and is often repeated in the surgical specimen (SS) after resection. As differences between CNB and SS testing may alter treatment decisions, we evaluated concordance between CNB and SS as well as associated changes in treatment and clinical outcomes.MethodsWe performed a retrospective analysis of breast cancer patients at our institution between January 2010 and May 2020. Concordance between CNB and SS was assessed for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). Survival in patients, including recurrence, metastatic recurrence, and death, were assessed using chi‐squared likelihood ratio.ResultsIn total, 961 patients met eligibility criteria. Concordance, minor discordance, total concordance (concordance plus minor discordance), and major discordance between CNB and SS were reported for ER (87.7%, 9.2%, 90.8%, and 2.9%), PR (58.1%, 29.1%, 87.2%, and 12.8%), and HER2 IHC (52.5%, 20.9%, 73.4%, 26.6%), respectively. HER2 FISH concordance and major discordance were 58.5% and 1.2%, respectively. Of major discordance, ER (48.2%, p < 0.001) and HER2 FISH (50.0%) led to more management changes than HER2 IHC (2.4%, p = 0.04) and PR (1.6%, p = 0.10). Patients with ER major discordance had increased risk of death (6.7% concordance vs. 22.2% major discordance, p = 0.004).ConclusionOverall, retesting ER and HER2 was more clinically beneficial than retesting PR. To aid decision‐making and minimize healthcare costs, we propose patient‐centered guidelines on retesting biomarker profiles.
In Silico Screening of Two‐Photon Absorption Properties of a Large Set of Bis‐Difluoroborate Dyes
Authors: Knysh Iryna , Jassar Mohammed Bin , Ośmiałowski Borys , Zaleśny Robert , Jacquemin Denis 
Published: June 2022

AbstractIn this work we strive to unravel the relationships between the two‐photon absorption (2PA) cross‐sections and structural modifications in an extended panel (280 compounds) of large difluoroborate dyes. More specifically, we use theoretical tools based on Time‐Dependent Density Functional Theory (TD‐DFT), to predict the one and two‐photon absorption properties of all compounds. The BF2‐carrying dyes usually posses a great interest for 2PA bioapplications as smartly designed BF2‐derivatives show good photophysical properties and high quantum yields in aqueous medium. For practical applications, it is important to maximize their 2PA response as well as absorption wavelength. This is why we explore here various strategies for maximizing the 2PA cross‐section: core modifications, multi‐branching, variation of the nature and length of the π‐conjugated linkers, addition of various donor and acceptor substituents. Our results suggest that large values of 2PA cross‐section and redshifted absorption wavelength can be achieved for all studied cores by using the vinylene‐type linkers and asymmetrical substitution with at least one strong peripheral donor group.
Defect‐Enriched ZnO/ZnS Heterostructures Derived from Hydrozincite Intermediates for Hydrogen Evolution under Visible Light
Authors: Zhi Yaqing , Yi Yuan , Deng Chenxi , Zhang Qiao , Yang Siyuan , Peng Feng 
Published: June 2022

AbstractIntroducing defect engineering into ZnO/ZnS heterojunction photocatalysts is an effective method to simultaneously improve their visible light performance and photocatalytic efficiency. Herein, a defect‐enriched ZnO/ZnS heterostructure photocatalyst was synthesized through a hydrozincite [Zn5(OH)6(CO3)2] intermediate‐deriving reaction. The mechanism analysis showed that there were interstitial Zn and Zn vacancies in the hydrozincite‐derived ZnO, while S vacancies and interstitial S and Zn vacancies were formed in ZnS components after calcination. These specific defect states endowed visible light response ability to both ZnO and ZnS components in the ZnO/ZnS photocatalysts. Under visible light irradiation, the photocatalytic hydrogen evolution rate of ZnO/ZnS reached 11.68 mmol h−1 g−1, and under simulated sunlight irradiation, the best photocatalytic hydrogen evolution rate could reach 27.94 mmol h−1 g−1, which was much higher than most previous reports. The analysis of energy band structure and photodeposition showed that the photocatalytic reduction sites were mainly on ZnS, and the photocatalytic reaction mainly followed the typical Z‐type mechanism. This work presents a simple and low‐cost method for the preparation of defects‐enriched ZnO/ZnS‐based photocatalytic materials with high photocatalytic activity and stability.
Carbon nanoparticles characteristics synthesized in pulsed radiofrequency discharge and their effect on surface hydrophobicity
Authors: Batryshev Didar , Utegenov Almasbek , Zhumadilov Rakhymzhan , Akhanova Nazym , Orazbayev Sagi , Ussenkhan Sultan , Lin Jiashu , Takahashi Kazuo , Bastykova Nuriya , Kodanova Sandugash , Gabdullin Maratbek , Ramazanov Tlekkabul 
Published: June 2022

AbstractCarbon nanoparticles were synthesized using a 13.56 MHz radiofrequency (RF) discharge of Ar/CH4 plasma in pulsed mode to control the nanoparticle size. Experimental observations have shown that the size of carbon nanoparticles increases with the frequency of the pulse signal. It was also found that by using a frequency modulated pulsed RF signal it is possible to control the size of carbon nanoparticles in the 40–70 nm range, where the plasma‐enhanced chemical vapour deposition method is the main mechanism for nanoparticle growth. Transmission electron microscopy image analysis showed two types of nanoparticles, some of which are an agglomerate of nanoparticles with an amorphous structure, while the others are nanometre‐sized with crystalline structures. Changes in the modulation frequency and synthesis time help to obtain different films with different values of the contact angle.
Evaluating the role of body size and habitat type in movement behavior in human‐dominated systems: A frog's eye view
Authors: Murphy Mason , Boone Michelle 
Published: June 2022

AbstractAnimal movement is a key process that connects and maintains populations on the landscape, yet for most species, we do not understand how intrinsic and extrinsic factors interact to influence individual movement behavior.Land‐use/land‐cover changes highlight that connectivity among populations will depend upon an individual's ability to traverse habitats, which may vary as a result of habitat permeability, individual condition, or a combination of these factors.We examined the effects of intrinsic (body size) and extrinsic (habitat type) factors on desiccation tolerance, movement, and orientation in three anuran species (American toads,Anaxyrus americanus; northern leopard frogs,Lithobates pipiens; and Blanchard's cricket frogs,Acris blanchardi) using laboratory and field studies to connect the effects of susceptibility to desiccation, size, and movement behavior in single‐habitat types and at habitat edges.Smaller anurans were more vulnerable to desiccation, particularly for species that metamorphose at relatively small sizes. Habitat type had the strongest effect on movement, while body size had more situational and species‐specific effects on movement. We found that individuals moved the farthest in habitat types that, when given the choice, they oriented away from, suggesting that these habitats are less favorable and could represent barriers to movement.Overall, our work demonstrated that differences in habitat type had strong impacts on individual movement behavior and influenced choices at habitat edges. By integrating intrinsic and extrinsic factors into our study, we provided evidence that population connectivity may be influenced not only by the habitat matrix but also by the condition of the individuals leaving the habitat patch.
Molecular phylogeny and phylogeography of ricefishes (Teleostei: Adrianichthyidae: Oryzias) in Sri Lanka
Authors: Sudasinghe Hiranya , Ranasinghe Tharindu , Wijesooriya Kumudu , Pethiyagoda Rohan , Rüber Lukas , Meegaskumbura Madhava 
Published: June 2022

AbstractRicefishes of the genus Oryzias occur commonly in the fresh and brackish waters in coastal lowlands ranging from India across Southeast Asia and on to Japan. Among the three species of Oryzias recorded from peninsular India, two widespread species, O. carnaticus and O. dancena, have previously been reported from Sri Lanka based on museum specimens derived from a few scattered localities. However, members of the genus are widespread in the coastal lowlands of Sri Lanka, a continental island separated from India by the shallow Palk Strait. Although recent molecular phylogenies of Adrianichthyidae represent near‐complete taxon representation, they lack samples from Sri Lanka. Here, based on sampling at 13 locations representative of the entire geographic and climatic regions of the island's coastal lowlands, we investigate for the first time the molecular phylogenetic relationships and phylogeography of Sri Lankan Oryzias based on one nuclear and two mitochondrial markers. Sri Lankan Oryzias comprise two distinct non‐sister lineages within the javanicus species group. One of these is represented by samples exclusively from the northern parts of the island; it is recognized as O. dancena. This lineage is recovered as the sister group to the remaining species in the javanicus group. The second lineage represents a species that is widespread across the island's coastal lowlands. It is recovered as the sister group of O. javanicus and is identified as O. cf. carnaticus. Ancestral‐range estimates suggest two independent colonizations of Indian subcontinent and Sri Lanka by widespread ancestral species of Oryzias during two discrete temporal windows: late Miocene and Plio‐Pleistocene. No phylogeographic structure is apparent in Sri Lankan Oryzias, suggesting that there are no strong barriers to gene flow and dispersal along the coastal floodplains, as is the case also for other generalist freshwater fishes in the island.
Incidence and predictors of worsening heart failure in patients with wild‐type transthyretin cardiac amyloidosis
Authors: Ladefoged Bertil Thyrsted , Dybro Anne , Dahl Pedersen Anders Lehmann , Rasmussen Torsten Bloch , Vase Henrik Ølholm , Clemmensen Tor Skibsted , Gillmore Julian , Poulsen Steen Hvitfeldt 
Published: June 2022

AbstractBackgroundPrognostic markers of survival have been identified in wild‐type transthyretin amyloidosis (ATTRwt), but limited data exist with respect to hospitalizations with worsening heart failure (WHF). Predictive markers of WHF have yet to be identified.MethodsFrom April 2017 to February 2021, 104 patients with ATTRwt were diagnosed and prospectively followed from the time of diagnosis to the time of death or the censoring date of 1 February 2021. Baseline patient characteristics, biomarkers, and advanced echocardiography were used to predict hospitalization with WHF.ResultsDuring the median follow‐up period of 23 months, 51% of patients were hospitalized due to WHF. Seventy‐three per cent of patients with WHF were admitted at least twice. Patients with WHF during the first year had significantly poorer survival (P < 0.001). Independent predictors of WHF during follow‐up were pacemaker implantation prior to diagnosis (PMI, P = 0.037) and right atrial volume index (RAVi, P = 0.008). Patients with PMI had a higher left ventricular mass index and poorer left ventricular and right ventricular systolic function indicating a more advanced stage of amyloid disease.ConclusionsA high incidence and recurrence of hospital admissions with WHF were demonstrated in contemporary patients with ATTRwt, which was associated with reduced survival. Patients with pacemaker devices prior to ATTRwt diagnosis experienced more frequent hospitalizations with WHF. PMI and right atrial enlargement were identified as independent predictors of WHF during follow‐up.
Prognostic values of B‐lines combined with clinical congestion assessment at discharge in heart failure patients
Authors: Kang Yu , Zhong Xue‐ke , Chen Qiao‐wei , Yang Zi‐xuan , Chen Xiao‐jing , Yu Peng‐ming , Zhang Qing 
Published: June 2022

AbstractAimsWe aim to investigate the additive effect of B‐lines on lung ultrasound (LUS) for predicting outcome in patients with heart failure (HF) when combined with conventional assessment of clinical congestion.Methods and resultsThis study prospectively enrolled 117 hospitalized HF patients (61 ± 16 years, 70.1% males) who underwent congestion assessment by the ‘wet/dry’ status, clinical congestion score (CCS), and B‐lines on LUS. The primary endpoint was all‐cause mortality or hospitalization for HF during the 180‐day follow‐up after discharge. The ‘Wet’, CCS ≥ 3, and B‐lines >5, indicators of congestion positive (+), were observed in 83.8%, 76.1%, and 70.1% of the patients on admission, respectively; and the numbers significantly decreased to 41.9%, 41.9%, and 35.9% at discharge, respectively. The agreement between the ‘wet/dry’ status and B‐lines (58.1%) or between CCS and B‐lines (56.4%) was moderate at discharge, in terms of both positive and both negative. By incorporating the B‐lines with assessment of clinical congestion, the patients at discharge were divided into three phenotypes as clinical congestion (+), clinical congestion (−) with B‐lines (+), and clinical congestion (−) with B‐lines (−). The Kaplan–Meier analysis showed a better survival in the both (−) group (‘wet/dry’ with B‐lines: Chi‐square 10.591, P = 0.005; CCS with B‐lines: χ2 6.239, P = 0.031). When the ‘wet’ patients (n = 49) being taken as the reference, the ‘dry’ patients with B‐lines (+) (n = 21) had an identical risk of the composite endpoint (hazard ratio [HR] adjusted for clinical covariates 1.021, 95% confidence interval [CI] 0.480–2.134, P = 0.974), while the ‘dry’ patients with B‐lines (−) (n = 47) had a lower risk (HR 0.264, 95% CI 0.113–0.617, P = 0.002). When the CCS (+) patients (n = 49) being regarded as the reference, similar results were obtained in the patients with CCS (−) but B‐lines (+) (n = 22) (HR 1.348, 95% CI 0.627–2.896, P = 0.444) as well as in those with both CCS (−) and B‐lines (−) (n = 46) (HR 0.447, 95% CI 0.202–0.992, P = 0.048).ConclusionsThe combination of B‐lines on LUS and conventional assessment helped to identify new phenotypes of congestion that aid in the risk stratification of discharged HF patients. Further investigation is warranted to determine whether this strategy could be adopted as a guide for decongestion therapy.
Changes in shore platform wetting and drying cycles following the 2016 Kaikōura earthquake: Implications for incipient marine terrace evolution
Authors: Horton Sophie L. , Stephenson Wayne J. , Dickson Mark E. 
Published: June 2022

AbstractCo‐seismic uplift of Kaikōura Peninsula in 2016 has substantially reduced the number of wetting and drying cycles that occur on the shore platforms and the newly uplifted incipient marine terraces. A simple empirical model incorporating field and laboratory measurements was used to determine the number and frequency of wetting and drying cycles. The mudstone supratidal terraces are vulnerable to material disintegration and slaking through sustained drying, and occasional sweeping by storm waves. Overall, wetting and drying cycles have decreased on six of eight field transects, between −8% and −148%, resulting in prolonged drying of the supratidal terraces following uplift (upwards of a 29% increase in annual drying hours). We conclude that accelerated rates of denudation due to enhanced drying post‐uplift are likely to return sections of the incipient mudstone terraces to their former intertidal pre‐uplift state, potentially removing evidence of the co‐seismic uplift event. Terrace preservation, however, will likely be highly variable between locations depending on its inherited morphology, lithological vulnerability, and the timing of any future tectonism.
Investigations On the Fish Acute Toxicity of Fragrance Ingredients Involving Chinese Fish Species and Zebrafish Embryos
Authors: Zhou Zhimin , Bai Yunfei , Su Tenghui , Zhang Dainan , Wang Zhen , Begnaud Frédéric , Gimeno Sylvia , You Jing 
Published: June 2022

Abstract
While zebrafish (Danio rerio) have been accepted worldwide for evaluating chemical hazards to aquatic vertebrates, and in some countries it is mandated to generate fish toxicity data using native species, such as Chinese rare minnow (Gobiocypris rarus) in China. This represents an additional regulatory constraint that may cause redundant tests, additional animal uses, and higher costs. Previous studies showed that juvenile G. rarus was more sensitive than zebrafish juveniles and embryos to metals. To better understand the sensitivity of G. rarus to organic chemicals, we selected 29 fragrance ingredients belonging to various chemical classes and with differing physicochemical properties, for which good quality zebrafish acute toxicity data were available and tested them with juvenile G. rarus and embryo D. rerio using the Organisation of Economic Co-operation and Development test guidelines. Chemical toxicity distribution (CTD) and chemical ratio distribution (CRD) models were established to systematically compare the sensitivity between juveniles of G. rarus and D. rerio, as well as between D. rerio embryos and juveniles. The results of the CTD models showed that for tested chemicals, the sensitivity of juvenile G. rarus was similar to that of D. rerio juveniles and embryos. The CRD comparisons revealed that juvenile G. rarus was slightly less sensitive by a factor of ~2 than juvenile D. rerio to ingredients belonging to Verhaar class 3 and Ecological Structure Activity Relationship ester class, while comparable to other chemicals. These comparative experiments demonstrated that fish toxicity data with G. rarus can be submitted for use in chemical registrations outside China, which would avoid repeating animal tests using D. rerio. Meanwhile, the similar sensitivity of zebrafish juveniles and embryos to fragrance ingredients confirmed the suitability of replacing juveniles by zebrafish embryos. Environ Toxicol Chem 2022;41:2305–2317. © 2022 SETAC
Abstract
Chemical toxicity distribution (CTD) and chemical ratio distribution (CRD) models showed that fish toxicity data with G. rarus can be submitted for use in chemical registrations, avoiding repeating animal tests using D. rerio.