bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural performance of alkali/acid‐ultrasound modified Agave fibers during the melt mixing process with polyvinyl alcohol
Authors: Sifuentes‐Nieves Israel , Hernandez‐Gamez Jose F. , Flores‐Silva Pamela C. , Gonzalez‐Morones Pablo , Yáñez‐Macías Roberto , Ramirez‐Vargas Eduardo , Hernández‐Hernández Ernesto 
Published: November 2022

AbstractThis study aims to investigate changes in the structural properties of alkali/acid‐ultrasound modified Agave fibers and their performance immersed on a polyvinyl alcohol (PVA) matrix with plasticizer during melt mixing processing. Structural analysis revealed that ultrasound enhances the effectiveness of the conventional alkaline/acid treatments to modify fibers since the simultaneous treatment increased the partial removal of lignocellulosic components, water molecules, and amorphous regions which improved their processability on a PVA matrix. Specific energy consumption values indicated that during melt mixing the modified fibers required more energy to expose the chains of cellulose fraction to function as an interaction site for PVA chains. Once the mixture was homogenized, the fiber‐matrix interactions promoted high viscosity, friction, and mechanical stress in the chamber. Therefore, the modified fibers restricted the interaction between plasticizer and PVA in the obtained films, resulting in a highly structured, and reinforced network, increasing the storage modulus as dynamic mechanical analysis indicated. These findings highlight a feasible way to valorize Agave fibers and allow the understanding of the matrix‐fiber interactions during melt mixing processing, useful to predict the structural and mechanical properties of the films.
In vivo transient expression of a viral silencing suppressor, NSs, derived from tomato spotted wilt virus decreases insect RNAi efficiencies
Authors: Kim Chul‐Young , Kim Yonggyun 
Published: November 2022

AbstractTomato spotted wilt virus is a single‐stranded RNA virus and causes a serious plant disease. Its horizontal transmission depends on some thrips species including Frankliniella occidentalis. Its genome encodes a nonstructural protein, nonstructural (NSs), which acts as a silencing suppressor and plays a crucial role in the pathogenicity by defending antiviral immunity using RNA interference (RNAi) in plant hosts. However, its physiological function as a silencing suppressor was not well clarified in insect vectors. This study assessed any change of RNAi efficiencies in two other insect systems by NSs expression. To this end, the gene was cloned into a eukaryotic expression vector and transiently expressed in two different insect species via in vivo transient expression (IVTE). After feeding the recombinant construct to non‐viruliferous F. occidentalis, NSs expression was observed for over 2 days in the thrips. Under this expression of NSs, thrips were rescued from a treatment of a toxic double stranded RNA specific to v‐ATPase. Interestingly, the thrips treated with IVTE significantly suppressed the expression of RNAi machinery genes such as SID and Dicer‐2. The recombinant vector expressing NSs was injected to a non‐vector insect, Spodoptera exigua, larvae. The larvae expressing NSs by the IVTE were highly susceptible to an infection of a RNA virus called iflavirus. These suggest that NSs acts as a silencing suppressor in insects and would be used for a synergist for RNA pathogens to control insect pests.
Biodistribution and delivery of oligonucleotide therapeutics to the central nervous system: Advances, challenges, and future perspectives
Authors: Goto Akihiko , Yamamoto Syunsuke , Iwasaki Shinji 
Published: November 2022

AbstractConsiderable advances have been made in the research and development of oligonucleotide therapeutics (OTs) for treating central nervous system (CNS) diseases, such as psychiatric and neurodegenerative disorders, because of their promising mode of action. However, due to the tight barrier function and complex physiological structure of the CNS, the efficient delivery of OTs to target the brain has been a major challenge, and intensive efforts have been made to overcome this limitation. In this review, we summarize the representative methodologies and current knowledge of biodistribution, along with the pharmacokinetic/pharmacodynamic (PK/PD) relationship of OTs in the CNS, which are critical elements for the successful development of OTs for CNS diseases. First, quantitative bioanalysis methods and imaging‐based approaches for the evaluation of OT biodistribution are summarized. Next, information available on the biodistribution profile, distribution pathways, quantitative PK/PD modeling, and simulation of OTs following intrathecal or intracerebroventricular administration are reviewed. Finally, the latest knowledge on the drug delivery systems to the brain via intranasal or systemic administration as noninvasive routes for improved patient quality of life is reviewed. The aim of this review is to enrich research on the successful development of OTs by clarifying OT distribution profiles and pathways to the target brain regions or cells, and by identifying points that need further investigation for a mechanistic approach to generate efficient OTs.
The mood effect in relation to impulsive online buying behavior
Authors: Arruda Filho Emílio José Montero , Oliveira Ronny Luis Sousa 
Published: November 2022

AbstractThis article analyzes impulsive buying behavior in scenarios where the consumer's negative or positive mood, oriented by emotional situations, stimulates an uncontrolled instinct in relation to the purchase. Four experimental studies were carried out to evaluate the influence of the mood state on impulsivity in different scenarios of consumption: online versus face‐to‐face shopping (Study 1); product characteristics – hedonic versus utilitarian product types in online environments (Study 2); the individual characteristic of self‐control in relation to the online purchase (Study 3a); and the individual characteristic of social value in relation to online consumption (Study 3b). The results demonstrate that consumers have greater impulsiveness within the online environment when they are in a positive mood, and that the positive mood maintains greater purchasing impulsiveness when the product is utilitarian, and when the consumer has low self‐control and/or high social value individually.
Type 2 diabetes mellitus stimulated pulmonary vascular inflammation and exosome biogenesis in rats
Authors: Rezaie Jafar , Hosseinpour Hossein , Rahbarghazi Reza , Keyhanmanesh Rana , Khanzadeh Shokoufeh , Mahdipour Mahdi , Soleimanpour Jafar , Ahmadi Mahdi 
Published: November 2022

AbstractIt has been shown that type 2 Diabetes Mellitus (T2DM) changes the paracrine activity of several cell types. Whether the biogenesis of exosomes is changed during diabetic conditions is the subject of debate. Here, we investigated the effect of T2M on exosome biogenesis in rat pulmonary tissue. Rats received a high‐fat diet regime and a single low dose of Streptozocin to mimic the T2DM‐like condition. A total of 8 weeks after induction of T2DM, rats were subjected to several analyses. Besides histological examination, vascular cell adhesion molecule 1 (VCAM‐1) levels were detected using immunohistochemistry (IHC) staining. Transcription of several genes such as IL‐1β, Alix, and Rab27b was calculated by real‐time polymerase chain reaction assay. Using western blot analysis, intracellular CD63 levels were measured. The morphology and exosome secretion activity were assessed using acetylcholinesterase (AChE) assay and scanning electron microscopy, respectively. Histological results exhibited a moderate‐to‐high rate of interstitial pneumonia with emphysematous changes. IHC staining showed an increased VCAM‐1 expression in the diabetic lungs compared with the normal conditions (p < .05). Likewise, we found the induction of IL‐1β, and exosome‐related genes Alix and Rab27b under diabetic conditions compared with the control group (p < .05). Along with these changes, protein levels of CD63 and AChE activity were induced upon the initiation of T2DM, indicating accelerated exosome biogenesis. Taken together, current data indicated the induction of exosome biogenesis in rat pulmonary tissue affected by T2DM. It seems that the induction of inflammatory niche is touted as a stimulatory factor to accelerate exosome secretion.
Ubiquitin specific protease 46 potentiates triple negative breast cancer development by stabilizing PGAM1‐mediated glycolysis
Authors: Ke Longzhu , Jia Zhaoyang , Gao Wei , Luo Li 
Published: November 2022

AbstractTriple‐negative breast cancer (TNBC) is a malignancy with high metastasis rate and poor prognosis. Limited drugs are effective for the treatment of TNBC patients. Ubiquitin specific proteases (USPs) are important posttranscription modulators that promote protein stability by reducing the ubiquitination of the proteins. Aberrant expression of USPs is involved in the development of numerous cancers. However, it remains poorly understood on the role of USP46 in TNBC growth and metastasis. In this study, we explored the clinical relevance, function and molecular mechanisms of USP46 in TNBC. USP46 expression was increased in breast cancer tissues. High expression of USP46 was associated with the poorer prognosis of the patients. Overexpression and knockdown experiments demonstrated that USP46 was critical for TNBC cell growth, migration, and tumorigenesis. Mechanistically, USP46 enhanced the protein stability of phosphoglycerate mutase 1 (PGAM1) via direct interaction. Importantly, USP46 stimulated the glycolysis and promoted the malignant growth of TNBC cells through upregulation of PGAM1. Our study reveals that USP46/PGAM1 axis contributes to TNBC progression and is a potential target for the treatment of TNBC patients.
Dominant immune cells in pregnancy and pregnancy complications: T helper cells (TH1/TH2, TH17/Treg cells), NK cells, MDSCs, and the immune checkpoints
Authors: Esparvarinha Mojgan , Madadi Sahar , Aslanian‐Kalkhoran Lida , Nickho Hamid , Dolati Sanam , Pia Helen , Danaii Shahla , Taghavi Simin , Yousefi Mehdi 
Published: November 2022

AbstractPregnancy problems including recurrent pregnancy loss, repeated implantation failure and pre‐eclampsia are common problems in the reproductive ages. Different reasons such as genetic, immunological, and environmental agents and also infections could develop these complications. In those cases in which the cause of the abortion is diagnosed, the chance of a successful pregnancy is increased by eliminating defective factors. However, in patients with unknown causes, there may be an imbalance in immune cells pattern. As a matter of fact, an inappropriate immune response is often associated with a failed pregnancy. Hence, the focus of treatment is to increase tolerance, not to suppress maternal immune system. These findings are linked to an elevated number of Treg cells and immune checkpoints through normal pregnancy. The present review discusses the balance of myeloid‐derived suppressor cells, natural killer cells, T cells, and immune checkpoints, and also targeting them to maintain pregnancy and prevent associated complications.
Hybrid coronary revascularization (HCR) versus coronary artery bypass grafting (CABG) in multivessel coronary artery disease (MVCAD): A meta‐analysis of 14 studies comprising 4226 patients
Authors: Nagraj Sanjana , Tzoumas Andreas , Kakargias Fotis , Giannopoulos Stefanos , Ntoumaziou Athina , Kokkinidis Damianos G. , Alvarez Villela Miguel , Latib Azeem 
Published: November 2022

AbstractObjectivesTo compare the outcomes of hybrid coronary revascularization (HCR) with traditional coronary artery bypass grafting (CABG) in multivessel coronary artery disease (MVCAD).BackgroundHCR has emerged as an alternative to CABG in patients with MVCAD. Through minimally invasive surgical techniques, HCR carries the potential for faster recovery postoperatively, fewer complications, and lower utilization of resources.MethodsSystematic search of electronic databases was conducted up to December 2021 and studies comparing HCR with CABG in the treatment of MVCAD were included in this meta‐analysis. Primary outcomes of interest were incidence of 5‐year mortality and major adverse cardiac and cerebral event (MACCE).ResultsFourteen studies (12 observational studies and 2 randomized controlled trials) comprising 4226 patients were included. The rates of 5‐year mortality (odds ratios [OR]: 1.55; 95% confidence interval [CI]: 0.92−2.62; I2 = 83.0%) and long‐term MACCE (OR: 0.97; 95% CI: 0.47−2.01; I2 = 74.7%) were comparable between HCR and CABG groups. HCR was associated with a significantly lower likelihood of perioperative blood transfusion (OR: 0.36; 95% CI: 0.25−0.51; I2 = 55.9%), shorter mean hospital stay (weighted mean difference: −2.04; 95% CI: −2.60 to −1.47; I2 = 54%), and risk of postoperative acute kidney injury (OR: 0.45; 95% CI: 0.23−0.88; p = 0.02). CABG demonstrated a lower likelihood of requiring long‐term repeat revascularization (OR: 1.51; 95% CI: 1.03−2.20; I2 = 18%) over a follow‐up duration of 29.14 ± 21.75 months.ConclusionThis meta‐analysis suggests that HCR is feasible and safe for the treatment of MVCAD. However, benefits of HCR should be carefully weighed against the increased long‐term risk of repeat‐revascularization when selecting patients, and further studies evaluating differences in long‐term mortality between HCR and CABG are required.
Serotonin syndrome due to concomitant use of linezolid and methadone
Authors: Masbough Farnoosh , Roshanzamiri Soheil , Rahimi Mitra , Sahraei Zahra , Evini Peyman Erfan Talab 
Published: November 2022

AbstractSerotonin syndrome is a potentially life‐threatening adverse drug reaction typically caused by a single or combination of two or more medications with serotonergic properties due to increased serotonin release. Our case is a 60‐year‐old drug‐addict man who was admitted to the poisoning department of Loghman hospital with methadone poisoning. On the fifth day of hospitalization and after initiating the linezolid treatment for VAP, the patient began to run a fever with agitation, tremor, spontaneous clonus movement in the hands, and tachycardia. Due to patients' manifestations and after ruling out other diagnoses, serotonin syndrome was confirmed with the possibility of concomitant use of linezolid and methadone. Linezolid administration was promptly discontinued, and vancomycin therapy was initiated (1000 mg twice a day intravenously). Supportive therapies were performed. Finally, tremor, rigidity, and clonus movement disappeared within 48 h.
Successful regenerative response of a severe bone defect in a right lower central incisor affected by a cemental tear
Authors: Nagahara Takayoshi , Takeda Katsuhiro , Inoue Sadayuki , Wada Keinoshin , Shiba Hideki 
Published: November 2022

AbstractCone‐beam computed tomography and clinical examinations including pulp vital testing and pocket probing depth showed a cemental tear with a severe labial alveolar bony defect, but no endodontic lesions, in #25, which had a sinus tract at the labial site, in a 75‐year‐old woman.
A case of chronic myelogenous leukemia with the T315I mutation who progressed to myeloid blast phase and was successfully treated with asciminib
Authors: Tomassetti Sarah , Lee Jennifer , Qing Xin 
Published: November 2022

AbstractPatients with chronic myelogenous leukemia (CML) harboring the T315I mutation who progress to blast phase CML while on ponatinib may be successfully treated with asciminib monotherapy following induction therapy with cytotoxic chemotherapy.
Case of atrial septal defect closure relieving refractory migraine
Authors: Hoshina Yuta , Iijima Hiroyuki , Kubota Mitsuru , Murakami Tsutomu , Nagai Akira 
Published: November 2022

AbstractThe effectiveness of patent foramen ovale closure for migraine has been previously discussed. By contrast, very few studies have reported the association between migraine and atrial septal defect closure. Here, we report a case in which atrial septal defect closure effectively relieved migraine headaches.
Anaphylaxis after prick‐to‐prick skin test to seafood allergy: A rare adverse event
Authors: Cherrez‐Ojeda Ivan , Robles‐Velasco Karla , Osorio María F. , Farfán Bajaña María José , Intriago Belen , M. Mobayedh Hassan , Al‐Nesf Maryam Ali 
Published: November 2022

AbstractAllergies to seafood are common all over the world. The prick‐to‐pricktest is used to diagnose allergic reactions. In this article, a femalepatient suffered an anaphylactic reaction 5 minutes following a Prick‐to‐Prick skin test. Therefore, it is important to stratify, recognize and treatthe anaphylactic reaction promptly.
Pulmonary Mucormycosis and hydatid cyst: A case report
Authors: Akbarieh Samira , Naghili Behrooz , Valizade Hamed , Beheshtirouy Samad , Sajedi Behnam , Haramshahi Morteza 
Published: November 2022

AbstractMucormycosis is a group of life‐threatening diseases caused by a fungus of the Mucoraceae family and has a higher mortality rate compared with other known fungal infections. Hydatid cyst, caused by Echinococcus, is a crucial health concern in endemic areas and the disease is characterized by slow‐growing cysts in the liver, lungs, or other organs. In this report, a woman with coexistence of hydatid cyst and Mucormycosis is introduced. The patient was a 52‐year‐old woman with approximately 6 years' history of uncontrolled diabetes mellitus and hypothyroidism, who presented with cough, sputum, and dyspnea 2 months ago. On the initial auscultation of the lungs, there was a decreased sound at the base of the left lung, and she had a fever. In blood tests, she had a high titer of erythrocyte sedimentation rate and 3+ C‐Reactive Protein. The symptoms in favor of hydatid cyst were observed in lung computed tomography and in pleural needle biopsy, hydatid cyst was confirmed. With this indication, she underwent wedge resection, and resection of the left lower lung cyst. Two samples are taken from the cyst side and the pathology report was consistent with Mucormycosis (wide filaments with a 90‐degree angle). The patient was immediately treated with liposomal amphotericin for 4 weeks. The Lung CT scan was performed before and after treatment. Albendazole was treated to treat hydatid cyst. After discharge, the treatment of the patient continued with oral Posaconazole, and after the treatment finalization, the general condition of the patient was good, and she did not have any complaints. In pulmonary diseases that do not respond significantly to surgical treatment (such as hydatid cyst), fungal disease (mucor) must be considered simultaneously. Mucormycosis is more prevalent in patients with uncontrolled diabetes, and it is necessary to be considered if these patients were infected with pneumonia and their symptoms did not improve with usual treatments.
Identifying putative key metabolites from fingerprinting metabolomics for the authentication of rice origin: A case study of Sengcu rice
Authors: Nguyen Hoa Quynh , Tran‐Lam Thanh‐Thien , Nguyen Tung Ngoc , Quan Thuy Cam , Dao Yen Hai , Le Giang Truong 
Published: November 2022

AbstractThe expanding scale and nature of rice fraud in the global food system has caused major economic and human health concerns. Herein, an untargeted metabolomics approach was utilized for the discrimination between authentic and commercial Sengcu rice, a local specialty cultivated by terraced farming in northern Vietnam. A total of 8398 positive and 5250 negative mode compounds were introduced to multivariate analyses for the construction of classification models. Both principal component analysis and partial least squares‐discriminant analysis (PLS‐DA) clearly distinguished between authentic and commercial Sengcu rice. The optimized PLS‐DA models indicated that five positive (DMG, RSA, RCA, PAL, and BOSe) and six negative mode variables (PXP, RXP, TDHP, ISS, MXP, and RGB) was sufficient for validated model discrimination with a classification error rate less than 1.13 × 10−4 determined from repeated k‐fold cross validation. These putative signature metabolites clearly separated authentic and commercial Sengcu rice in the hierarchical clustering models. In addition, the isolated metabolite TDHP also reflected the difference in cultivation practices between authentic and commercial Sengcu rice. Overall, we have proposed an effective method for the identification of key metabolites from fingerprinting metabolomics, and it could serve as a fundamental approach for other in‐depth food authentication studies.
Kinetic modelling of 1, 3, 5‐triisopropylbenzene catalytic cracking using a CREC Riser Simulator emulating FCC operation: The C/O ratio effect
Authors: Medina‐Pedraza Cesar , Alkhlel Abdualkaber , de Lasa Hugo 
Published: November 2022

AbstractThe present study establishes the suitability of a kinetic model for the catalytic cracking of 1, 3, 5‐triisopropylbenze (TIPB) using the data obtained in the Chemical Reactor Engineering Centre (CREC) Riser Simulator. The postulated kinetic model accounts for both the TIPB and the various major products formed experimentally, such as: 1, 3‐diisopropylbenzene, isopropylbenzene, benzene, propylene, and coke. It is proven that the proposed kinetics is suitable to describe the chemical concentration changes in a CREC Riser Simulator at various reaction times, partial pressures, temperatures, and C/O (catalyst/feedstock) ratios. It is demonstrated that the proposed kinetics simulates well the experimental data from the CREC Riser Simulator, including an experimentally observed C/O optimum ratio. It is anticipated that this type of kinetic model, accounting for intrinsic kinetics, coke deactivation, and diffusional phenomena, could have significant value in establishing the influence of catalyst solid fluxes, at set hydrocarbon feed fluxes, in both industrial riser and downer fluid catalytic cracking (FCC) units.
The efficacy of nitroglycerin to prevent radial artery spasm and occlusion during and after transradial catheterization: A systematic review and meta‐analysis of randomized controlled trials
Authors: Abdelazeem Basel , Abuelazm Mohamed T. , Swed Sarya , Gamal Mohamed , Atef Mostafa , Al‐Zeftawy Mohamed A. , Noori Muhammad A. , Lutz Anthony , Volgman Annabelle S. 
Published: November 2022

AbstractRadial artery spasm (RAS) is the most common cause of transradial access site crossover and is a common intra‐procedural complication. RAS incidence can lead to radial artery occlusion (RAO) postprocedure, preventing the radial artery as a future access site. We evaluated the efficacy of nitroglycerin preventing RAS and RAO during transradial catheterization discussing the different routes of administration, including topical, subcutaneous, and intra‐arterial. A systematic review and meta‐analysis included all relevant articles until April 23, 2022. We searched six databases Google Scholar, Web of Science, SCOPUS, EMBASE, PubMed (MEDLINE), and CENTRAL. We registered our review protocol in PROSPERO with ID: CRD42022330356. We included 11 trials with 5814 patients. Compared to placebo, the pooled analysis favored subcutaneous nitroglycerin in preventing RAS (risk ratio [RR]: 0.57 with 95% confidence interval [CI] [0.43–0.77], p = .0003) and RAO (RR: 0.39 with 95% CI [0.16–0.98], p = .05). In contrast to the intra‐arterial nitroglycerin that showed nonstatistically significant results in preventing RAS and RAO (RR: 0.8 with 95% CI [0.63–1.02], p = .07)‐ (RR: 0.78 with 95% CI [0.6–1.01], p = .06)), respectively. Also, topical nitroglycerin did not prevent RAS (RR: 0.73 with 95% CI [0.42–1.24], p = .24). Compared with placebo, subcutaneous nitroglycerin during transradial catheterization reduced the incidence of RAS and RAO. Meanwhile, Intra‐arterial and topical nitroglycerin did not show statistically significant outcomes. Subcutaneous nitroglycerin may be a practical and cost‐effective technique to facilitate transradial catheterization; however, more RCTs are needed to evaluate the subcutaneous versus intra‐arterial nitroglycerin administration.