bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased annual methane uptake driven by warmer winters in an alpine meadow
Authors: Wang Peiyan , Wang Jinsong , Elberling Bo , Yang Lu , Chen Weinan , Song Lei , Yan Yingjie , Wang Song , Pan Junxiao , He Yunlong , Niu Shuli 
Published: February 2022

AbstractPronounced nongrowing season warming and changes in soil freeze–thaw (F–T) cycles can dramatically alter net methane (CH4) exchange rates between soils and the atmosphere. However, the magnitudes and drivers of warming impacts on CH4 uptake in different stages of the F–T cycle are poorly understood in cold alpine ecosystems, which have been found to be a net sink of atmospheric CH4. Here, we reported a year‐round ecosystem daily CH4 uptake in an alpine meadow on the Qinghai‐Tibetan Plateau after a 5‐year warming experiment that included a control, a low‐level warming treatment (+2.4℃ at 5 cm soil depth), and a high‐level warming treatment (+4.5℃ at 5 cm soil depth). We found that warming shortened the F–T cycle under the low‐level warming and soils did not freeze under the high‐level warming. Although both warming treatments increased the mean CH4 uptake rate, only the high‐level warming significantly increased annual CH4 uptake compared to the control. The warming‐induced stimulation of CH4 uptake mainly occurred in the cold season, which was mostly during spring thaw under low‐level warming and during the frozen winter under high‐level warming due to a longer period with thawed soil. We also found that warming significantly stimulated daily CH4 uptake mainly by reducing near‐surface soil water content in the warm season, whereas both soil water content and temperature controlled daily CH4 uptake in different ways during the autumn freeze, frozen winter, and spring thaw periods of the control. Our study revealed a strong warming effect on CH4 uptake during the entire F–T cycle in the alpine meadow, especially the unfrozen winter. Our results also suggested the important roles of soil pH, available phosphorus, and methanotroph abundance in regulating annual CH4 uptake in response to warming, which should be incorporated into biogeochemical models for accurately forecasting CH4 fluxes under future climate scenarios.
An innovation resistance theory perspective on home service applications: The moderating role of country context
Authors: Kumar Poonam , Chauhan Sumedha , Jaiswal Mahadeo. P. 
Published: February 2022

AbstractOn‐demand home service applications (HSAs) have revolutionized the service industry and are gaining high popularity. By using the innovation resistance theory in HSA context, the present study aimed to (a) examine the relationships of consumer barriers with trust and word of mouth (WOM) and (b) analyze how country context moderates the relationships of consumer barriers with trust. Survey data were gathered from 343 respondents (India = 216, The USA = 127) and analyzed using SmartPLS 3 software. The results showed that value barrier, risk barrier, and image barrier negatively affect trust and WOM. While the tradition barrier is insignificantly associated with trust and WOM, and usage barrier negatively relates to WOM only. The study also discovered the positive association of trust with WOM. The study further found that the country context moderates the relationship of value barrier, risk barrier, and image barrier with trust. Finally, implications for theory and practice are presented.
Influence of xanthan gum and gluten on in vitro digestibility and textural properties of rice bread
Authors: Sasaki Tomoko 
Published: February 2022

SummaryStarch digestibility of gluten‐free bread has been expected to be suppressed for the purpose of decreasing glycemic response. The objective of this study was to investigate the effects of adding xanthan gum and gluten on starch and protein digestibility of rice bread prepared using the developed recipe involving pickering stabilization of foams and emulsions. The extent of starch digestion of gluten‐free bread was suppressed by adding 2% xanthan gum from 79.8% to 57.3%. This suppressive effect was diminished by using gluten and that of rice bread containing 2% xanthan gum and 20% gluten was 75.5%. The extent of starch digestion of gluten‐free bread was similar or less than that of bread containing gluten. The gluten‐free bread with 2% xanthan gum had significantly lower loaf volume, porosity, and sticker structure of breadcrumb than the control. The suppressive effects of xanthan gum on starch and protein digestion were mainly dependent on reducing accessibility of the enzyme into the inner structure.
Exposure to maternal fuels during pregnancy and offspring hepatic fat in early childhood: The healthy start study
Authors: Cohen Catherine C. , Francis Ellen C. , Perng Wei , Sauder Katherine A. , Scherzinger Ann , Sundaram Shikha S. , Shankar Kartik , Dabelea Dana 
Published: February 2022

SummaryBackgroundIntrauterine overnutrition has been associated with paediatric nonalcoholic fatty liver disease (NAFLD), but the exact mechanisms involved remain unclear.ObjectiveTo examine whether maternal fuels and metabolic markers during pregnancy are associated with offspring hepatic fat in childhood.MethodsThis analysis included 286 mother–child pairs from the Healthy Start Study, a longitudinal pre‐birth cohort in Colorado. Fasting blood draws were collected in early pregnancy (~17 weeks) and mid‐pregnancy (~27 weeks). Offspring hepatic fat was assessed by magnetic resonance imaging (MRI) at ~5 years.ResultsIn early pregnancy, maternal triglycerides (TGs) and free fatty acids (FFAs) were positively associated with offspring hepatic fat [Back‐transformed β (95% CI): 1.15 (1.05, 1.27) per 1 standard deviation (SD) TGs; 1.14 (1.05, 1.23) per 1 SD FFAs]. Maternal total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C) were also associated with offspring hepatic fat, but only among boys [1.22 (1.08, 1.37) per 1 SD TC; 1.21 (1.07, 1.37) per 1 SD LDL‐C]. In mid‐pregnancy, only maternal TGs remained associated with offspring hepatic fat. Adjusting for potential confounders or mediators did not affect associations.ConclusionsMaternal lipid concentrations, especially in early pregnancy, are associated with higher offspring hepatic fat, and may, therefore, be targeted in future interventions among pregnant women.
The economic burden of influenza among adults aged 18 to 64: A systematic literature review
Authors: de Courville Caroline , Cadarette Sarah M. , Wissinger Erika , Alvarez Fabián P. 
Published: February 2022

AbstractWhile the economic burden of influenza infection is well described among adults aged 65 and older, less is known about younger adults. A systematic literature review was conducted to describe the economic burden of seasonal influenza in adults aged 18 to 64 years, to identify the main determinants of direct and indirect costs, and to highlight any gaps in the existing published evidence. MEDLINE and Embase were searched from 2007 to February 7, 2020, for studies reporting primary influenza‐related cost data (direct or indirect) or absenteeism data. Of the 2613 publications screened, 51 studies were included in this review. Half of them were conducted in the United States, and 71% of them described patients with influenza‐like illness rather than laboratory‐confirmed disease. Only 12 studies reported cost data specifically for at‐risk populations. Extracted data highlighted that within the 18‐ to 64‐year‐old group, up to 88% of the economic burden of influenza was attributable to indirect costs, and up to 75% of overall direct costs were attributable to hospitalizations. Furthermore, within the 18‐ to 64‐year‐old group, influenza‐related costs increased with age and underlying medical conditions. The reported cost of influenza‐related hospitalizations was found to be up to 2.5 times higher among at‐risk populations compared with not‐at‐risk populations. This review documents the considerable economic impact of influenza among adults aged 18 to 64. In this age group, most of the influenza costs are indirect, which are generally not recognized by decision makers. Future studies should focus on at‐risk subgroups, lab‐confirmed cases, and European countries.
Novel rare earth free phosphors CsMg2P3O10: Mn2+ with efficient and ultra‐broadband red emission for plant growth LEDs
Authors: Dai Heng , Li Shanshan , Li Zhuowei , Li Jiankun , Xin Shuangyu , Wang Chuang , Zhu Ge , Dong Bin 
Published: February 2022

AbstractAn efficient and ultra‐broadband red phosphor CsMg2P3O10: Mn2+ (CMPO: Mn2+) is first synthesized toward indoor plant growth LEDs. The phase purity, element composition, crystal, and local electronic structure are explored to discuss the structure and photoluminescence properties. Structure refinement and series X‐ray diffractometer (XRD) results show that CMPO: Mn2+ is well crystallized in an orthogonal crystal system. The diffuse reflection and excitation spectra show that CMPO: Mn2+ has strong absorption around near ultraviolet region, assigned to the [6A1 → 4E(4D), 4T2(4D), [4A1(4G), 4E(4G)], and 4T1(4G)] transitions of Mn2+, respectively. Upon 415 nm excitation, an efficient red emission centered at 647 nm with ultra‐broad full width at half‐maximum (FWHM ∼ 100 nm) and high quantum efficiency (IQE ∼ 44.3 %) is observed, and because of the ultra‐broad FWHM, the red emission is well accordant with the absorption spectra band of phytochrome PR and PFR. The optimal doping contents, lifetime as well as interaction mechanism of CMPO: Mn2+ are discussed in detail. Finally, the excellent thermal stability (84.5% @ 140°C) and related thermal quenching mechanism of CMPO: Mn2+ are discussed. The above results indicate that CMPO: Mn2+ phosphors have great potential for application in plant growth LEDs.
First‐principles investigation of elastic and electronic properties of double transition metal carbide MXenes
Authors: Jayan Rahul , Vashisth Aniruddh , Islam Md Mahbubul 
Published: February 2022

AbstractWe use first‐principles‐based density functional theory (DFT) calculations to investigate the structural, elastic, and electronic properties of various pristine and oxygen (O)‐functionalized double transition metal (DTM) MXenes with general formulas of M2′M′′C2 and M2′M′′C2O2, where M′ = Mo, Cr and M′′ = Ti, V, Nb, Ta. The dynamic stability of the DTM MXenes are assessed and elastic stiffness constants (Cij) are used to investigate the mechanical stability and properties of the compositions. The calculated elastic properties of the pristine Mo‐based MXenes are found to be superior compared to Cr‐based compounds. Furthermore, the O‐functionalized MXenes exhibit improved in‐plane elastic constants, Young's moduli, and shear moduli compared to their pristine counterpart. We observe that the hybridization of the energy states results in stronger covalent interactions as such increased elastic properties for the M2′M′′C2O2 MXenes. Ashby plot clearly demonstrates superior materials properties of O‐functionalized Mo‐based DTM MXenes compared to other commonly known two‐dimensional materials. All the MXenes exhibit metallic character evident from the density of states (DOS) calculations. Additionally, the work functions are studied and the calculated values are higher in the case of O‐functionalized MXenes. Overall, this work will be a guide for future investigations on the mechanical properties of DTM MXenes for their targeted applications in structural nanocomposites.
Functional niche constraints on carnivore assemblages (Mammalia: Carnivora) in the Americas: What facilitates coexistence through space and time?
Authors: Arias‐Alzate Andrés , Arroyave Felber J. , Romero Goyeneche Oscar Y. , Hurtado Heredia Rafael G. , González‐Maya José F. , Arroyo‐Cabrales Joaquín , Peterson A. Townsend , Martínez‐Meyer Enrique 
Published: February 2022

AbstractAimMammalian carnivores are among the best studied groups in terms of evolutionary history. However, the effects of species interactions in shaping community assemblages remain poorly understood. We hypothesize that indirect interactions via ecological trait filtering play a key role in structuring carnivoran assemblages, mediate coexistence and thus should show high functional diversity (FD) in space and time at continental scales.LocationThe Americas.TaxonMammalian carnivores (Mammalia: Carnivora).MethodsWe followed a macroecological perspective via ecological network analyses for indirect interactions and assessed the underlying FD across space and from the last interglacial to the present in the Americas. We analysed the potential distributions and six ecological traits of 88 species to establish possible mechanisms that enables species to coexist and the underlying diversity patterns. We compared the empirical results with two null models and two sensitivity analyses.ResultsCo‐occurring carnivore species presented ecological segregation driven mainly by a size ratio (SR) relationship, called here the body size spatialanti‐clusteringeffect. The underlying FD patterns showed low redundancy towards the tropics and the poles during the times evaluated. However, during the last glacial maximum, shifts occurred primarily at high latitudes in North America. This shift affected theSRrelationship and therefore changed FD patterns. These local‐to‐continental interactions mediated by theSRare significant from an ecological and biogeographic perspective, suggesting a robust and consistent trend in which carnivore species of similar size have a lower probability of occupying the same area unless they differentiate in other ecological trait spaces.Main conclusionsTheSRrelationship is potentially a primary mechanism limiting carnivore coexistence, reflecting functional filtering. TheSRtends to be conservative across different ecological trait groups and through time and space. We propose that the body‐size spatialanti‐clusteringeffect can directly measure species' coexistence and mediate FD patterns in the Americas.
Sex‐related differential susceptibility to ponatinib cardiotoxicity and differential modulation of the Notch1 signalling pathway in a murine model
Authors: Madonna Rosalinda , Pieragostino Damiana , Cufaro Maria Concetta , Del Boccio Piero , Pucci Angela , Mattii Letizia , Doria Vanessa , Cadeddu Dessalvi Christian , Zucchi Riccardo , Mercuro Giuseppe , De Caterina Raffaele 
Published: February 2022

AbstractPonatinib (PON), a tyrosine kinase inhibitor approved in chronic myeloid leukaemia, has proven cardiovascular toxicity. We assessed mechanisms of sex‐related PON‐induced cardiotoxicity and identified rescue strategies in a murine model. PON+scrambled siRNA‐treated male mice had a higher number of TUNEL‐positive cells (%TdT+6.12 ± 0.17), higher percentage of SA‐β‐gal‐positive senescent cardiac area (%SA‐β‐gal 1.41 ± 0.59) and a lower reactivity degree (RD) for the survival marker Bmi1 [Abs (OD) 5000 ± 703] compared to female (%TdT+3.75 ± 0.35; %SA‐β‐gal 0.77 ± 0.02; Bmi1 [Abs (OD) 8567 ± 2173]. Proteomics analysis of cardiac tissue showed downstream activation of cell death in PON+siRNA scrambled compared to vehicle or PON+siRNA‐Notch1‐treated male mice. Upstream analysis showed beta‐oestradiol activation, and downstream analysis showed activation of cell survival and inhibition of cell death in PON+scrambled siRNA compared to vehicle or PON+siRNA‐Notch1‐treated female mice. PON+scrambled siRNA‐treated mice also had a downregulation of cardiac actin—more marked in males—and vessel density—more marked in females. Female hearts showed greater cardiac fibrosis than their male counterparts at baseline, with no significant change after PON treatment. PON+siRNA‐scrambled mice had less fibrosis than vehicle or PON+siRNA‐Notch1‐treated mice. The left ventricular systolic dysfunction showed by PON+scrambled siRNA‐treated mice (male %EF 28 ± 9; female %EF 36 ± 7) was reversed in both PON+siRNA‐Notch1‐treated male (%EF 53 ± 9) and female mice (%EF 52 ± 8). We report sex‐related differential susceptibility and Notch1 modulation in PON‐induced cardiotoxicity. This can help to identify biomarkers and potential mechanisms underlying sex‐related differences in PON‐induced cardiotoxicity.
Lymphocyte percentage as a valuable predictor of prognosis in lung cancer
Authors: Huang Hong , Li Lei , Luo Wenxin , Yang Yongfeng , Ni Yinyun , Song Tingting , Zhu Yihan , Yang Ying , Zhang Li 
Published: February 2022

AbstractLymphocytes and neutrophils are involved in the immune response against cancer. This study aimed to investigate the relationship between lymphocyte percentage/neutrophil percentage and the clinical characteristics of lung cancer patients, and to explore whether they could act as valuable predictors to ameliorate lung cancer prognosis. A total of 1312 patients were eligible to be recruited. Lymphocyte percentage and neutrophil percentage were classified based on their reference ranges. Survival curves were determined using Kaplan–Meier method, and univariate and multivariate cox regression analyses were performed to identify the significant predictors. Decision curve analysis was used to evaluate the clinical benefit. The results of both training and validation cohorts indicated that lymphocyte percentage exhibited high correlation with clinical characteristics and metastasis of lung cancer patients. Both lymphocyte percentage and neutrophil percentage were closely associated with survival status (all p < 0.0001). Low lymphocyte percentage could act as an indicator of poor prognosis; it offered a higher clinical benefit when combined with the clinical characteristic model. Our findings suggested that pretreatment lymphocyte percentage served as a reliable predictor of lung cancer prognosis, and it was also an accurate response indicator in lung adenocarcinoma and advanced lung cancer. Measurement of lymphocyte percentage improved the clinical utility of patient characteristics in predicting mortality of lung cancer patients.
DEC1 promotes progression of Helicobacter pylori‐positive gastric cancer by regulating Akt/NF‐κB pathway
Authors: Jia Yanfei , Liu Yanyan , Zhu Jingyu , Liu Liang , Ma Xiaoli , Liu Duanrui , Han Shuyi , Zhang Lulu , Ling Zhi‐Qiang , Wang Yunshan 
Published: February 2022

AbstractHelicobacter pylori (H. pylori) infection plays a crucial role in the initiation and progression of gastric cancer (GC). Differentiated embryo‐chondrocyte expressed gene 1 (DEC1) is dysregulated in some cancers and may regulate cell proliferation in specific contexts. Of note, DEC1 is emerging as one of the important factors regulating cellular responses in microenvironment. However, the triggers and precise regulation mechanism for DEC1 during inflammatory carcinoma transformation of GC are unclear. In this study, we identified DEC1 was upregulated in both H. pylori‐infected gastric tissues and GC cells. DEC1 expression was positively associated with H. pylori infection status and GC progression. DEC1‐positive expression indicated a poorer prognosis in H. pylori‐positive GC. DEC1 was required for H. pylori‐induced GC cells proliferation. Mechanistically, H. pylori infection significantly activated Akt/NF‐κB signal pathway and this induction depend on DEC1 expression level in GC cells. Importantly, their interaction pathway was further verified by H. pylori‐positive gastritis mice model. Taken together, our findings identified a novel function of DEC1 in GC. H. pylori infection induce DEC1 expression, and which leading to the progression of GC through activating Akt/ NF‐κB signalling pathway. Blocking DEC1/Akt/NF‐κB, therefore, presents a promising novel therapeutic strategy for H. pylori‐positive GC.
Unique motif shared by HLA‐B*59:01 and HLA‐B*55:02 is associated with methazolamide‐induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Han Chinese
Authors: Jiang M. , Yang F. , Zhang L. , Xu D. , Jia Y. , Cheng Y. , Han S. , Wang T. , Chen Z. , Su Y. , Zhu Z. , Chen S. , Zhang J. , Wang L. , Yang L. , Yang J. , Luo X. , Xing Q. 
Published: February 2022

AbstractBackgroundMethazolamide (MTZ) has been occasionally linked to the lethal Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which are associated with HLA‐B*59:01. However, some MTZ‐induced SJS/TEN (MTZ‐SJS/TEN) cases are negative for HLA‐B*59:01, implying that other genetic factors besides HLA‐B*59:01 are contributing to MTZ‐SJS/TEN.ObjectivesTo comprehensively identify HLA and non‐HLA genetic susceptibility to MTZ‐SJS/TEN in Han Chinese.MethodsEighteen patients with MTZ‐SJS/TEN, 806 subjects of the population control and 74 MTZ‐tolerant individuals were enrolled in this study. Both exome‐wide and HLA‐based association studies were conducted. Molecular docking analysis was employed to simulate the interactions between MTZ and risk HLA proteins.ResultsWe found a strong signal in the major histocompatibility complex region on chromosome 6 with 22 SNPs reaching exome‐wide significance. Compared with MTZ‐tolerant controls, a significant association of HLA‐B*59:01 with MTZ‐SJS/TEN was validated [odds ratio (OR) = 146.00, 95% confidence interval (CI): 16.12–1321.98; P = 6.19 × 10−10]. Moreover, 66.7% of MTZ‐SJS/TEN patients negative for HLA‐B*59:01 were carriers of HLA‐B*55:02, whilst 2.7% of the tolerant individuals were observed with HLA‐B*55:02 (OR = 71.00, 95% CI: 7.84–643.10; P = 1.43 × 10−4). Within HLA‐B protein, the E45‐L116 motif could completely explain the association of HLA‐B*59:01 and HLA‐B*55:02 with MTZ‐SJS/TEN (OR = 119.33, 95% CI: 29.19–1227.96; P = 4.36 × 10−13). Molecular docking analysis indicated that MTZ binds more stably to the pocket of HLA‐B*59:01 and HLA‐B*55:02 than to that of non‐risk alleles of HLA‐B*40:01 and HLA‐C*01:02.ConclusionsThis study confirmed the association of HLA‐B*59:01 with MTZ‐SJS/TEN and identified HLA‐B*55:02 as a novel risk allele in Han Chinese with the largest sample size to date. Notably, the rs41562914(A)‐rs12697944(A) haplotype, encoding E45‐L116, is capable of serving as a powerful genetic predictor for MTZ‐SJS/TEN with a sensitivity of 89% and specificity of 96%.
Development of a patient‐reported experience measure for chronic inflammatory skin diseases
Authors: Van den Steen E. , Ramaekers D. , Horlait M. , Gutermuth J. 
Published: February 2022

AbstractBackgroundPatient involvement and high‐quality patient‐provider interactions are critical factors for quality of care in chronic inflammatory skin diseases. Also, assessing the patient's perspective contributes to optimizing care delivery and patient's experience. Until today, no user‐friendly tools to measure patient experiences exist within immunodermatology.ObjectivesThe aim of this study was to identify the relevant items for patient's experience in immunodermatology and develop a concise questionnaire to assess patient's experience in routine clinical care.MethodsPotential relevant items for measuring patient's perspective of immunodermatology care were identified by a literature search. From this longlist, a shortlist from patient's perspective was distilled by semi‐structured interviews with a diverse patient group. This list was reduced to final items using a modified Delphi method in a multi‐stakeholder focus group. For each item, one question was formulated to generate the Patient‐Reported Experience Measure (PREM) questionnaire. A first internal validation was achieved by an email round.ResultsForty longlist items were categorized into five domains (access to care, patient centeredness, access to information, care process and satisfaction). During interview rounds, 19 shortlist items were selected if mentioned by ≥40% of interviewees. Via the focus group, the most important items were chosen by participant consensus. For each item, a question was formulated. The final PREM covers 11 items (plus 2 in case of a first consult). The first internal validation showed that the tool is clear, understandable and has an ideal length.ConclusionThis short user‐friendly PREM can be used in scientific and routine settings to improve care for patients who suffer from chronic inflammatory skin diseases.