bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial intelligence and perinatology: a study on accelerated academic production- a bibliometric analysis
Authors: Kılınçdemir Turgut Ümran 
Published: February 2025

ObjectiveThe main purpose of this bibliometric study is to compile the rapidly increasing articles in the field of perinatology in recent years and to shed light on the research areas where studies are concentrated.Materials and methodsThis bibliometric study was conducted using the Thomson ISI Web of Science Core Collection (WOSCC) system on May 4, 2024, with specific keywords. The abstracts of 1,124 articles that met the criteria were reviewed, and 382 articles related to perinatology were evaluated. Keyword co-occurrence, co-citation of authors, and co-citation of references analyses were conducted using VOSviewer (version 1.6.19). Out of these, 121 articles with 10 or more citations were analyzed in terms of their content and categorized under the headings “Purpose of Evaluation,” “Medical Methods and Parameters Used,” “Output To Be Evaluated,” and “Fetal System or Region Being Evaluated.”ResultsIn this bibliometric study, it was found that the most frequently published journal among the 382 examined articles was Medical Image Analysis, while the journals with the most publications in the field of perinatology were Prenatal Diagnosis and Ultrasound in Obstetrıcs &amp; Gynecology. The most commonly used keyword was “deep learning” (115/382). Among the 121 highly cited articles, the most common purpose of evaluation was “Prenatal Screening.” Artificial intelligence was most frequently used in ultrasound (59.8%) imaging, with MRI (20.5%) in second place. Among the evaluated outputs, “organ scanning” (35/121) was in first place, while “biometry” (34/121) was in second place. In terms of evaluated systems and organs, “growth screening” (35/121) was the most common, followed by the “neurological system” (33/121) and then the “cardiovascular system” (18/121).ConclusionI has witnessed the increasing influence of artificial intelligence in the field of perinatology in recent years. This impact may mark the historic beginning of the transition to the AI era in perinatology. Milestones are being laid on the path from prenatal screening to prenatal treatment.
Utility of the combination of IVIM-DWI MRI and baseline eGFR for identifying a high risk of chronic kidney disease progression
Authors: Yu Yazhen , Zhang Wei , Zhu Lina , Zhou Han , Liang Shaoshan , Zhang Longjiang , Liu Zhihong , Zhang Jiong 
Published: February 2025

BackgroundCurrently, the baseline estimated glomerular filtration rate (eGFR), the urine albumin level and renal fibrosis are the common risk and prognostic factors for chronic kidney disease (CKD). Intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) is a proven noninvasive tool for assessing renal fibrosis. The aim of this study was to evaluate whether IVIM-DWI could be used to identify high-risk patients with CKD during long-term follow-up.MethodsIn this exploratory study, 62 CKD patients who were followed for 5 years and who underwent renal biopsy and IVIM-DWI magnetic resonance imaging (MRI) at the National Clinical Research Center of Kidney Disease in China were enrolled. We recorded baseline data, including clinical, pathology and MRI parameters, and evaluated the associations between baseline parameters and renal outcomes. The value of DWI parameters in predicting end-stage kidney disease (ESKD) was compared with that of clinical and pathological data.ResultsThe mean baseline eGFR was 78.1 ± 28.05 ml/min/1.73 m2, and the median eGFR slope was −0.07 (−0.43–0.06) ml/min/1.73 m2/yr. Sixteen patients eventually developed ESKD. The values of perfusion fraction (f) were positively correlated with the eGFR slope (rs = 0.54, p = 0.028). The results of the receiver operating characteristic (ROC) analysis demonstrated that the areas under the curve (AUCs) of total apparent diffusion coefficient (ADCT), true diffusion coefficient (D) and f in distinguishing ESKD were 0.778 (95% confidence interval [95% CI] 0.65–0.906; p = 0.001), 0.893 (95% CI 0.816–0.97; p &lt;0.001), and 0.823 (95% CI 0.706–0.939; p &lt; 0.001), respectively. For the combination of baseline eGFR with both D and f, the AUC was significantly greater than that for the combination of baseline eGFR and interstitial extracellular matrix volume [AUC 0.955 (95% CI, 0.909 to 1.000) vs. AUC 0.886 (95% CI, 0.803 to 0.969), p = 0.049]. Cox proportional hazard regression revealed that f was a risk and prognostic factor for ESKD after adjustment for baseline variables (p = 0.006).ConclusionThe combination of baseline eGFR and IVIM-DWI outperforms pathological factors alone in the diagnosis of long-term kidney dysfunction. This study indicated that IVIM-DWI could be a promising tool for identifying patients at high risk of CKD progression.
High-throughput sequencing explores the genetic variability of endophytic bacteria in three Sichuan bamboo species (Phyllostachys edulis, Bambusa rigida, and Pleioblastus amarus)
Authors: Yan Kuan , Li Xinyi , Cai Yu , Meng Lina , Wei Qin , Zhao Xianming , M. Y. Heakel Rania , M. Atif Amr , A. Abd Elhamid Mohamed , A. Soaud Salma , H. El-Sappah Ahmed 
Published: February 2025

IntroductionBamboo is a sustainable and degradable resource for sustenance, high-strength cellulose microfibers, and synthetic fiber in China. Endophytic bacteria enhance root development and ethylene levels, benefiting the host plants’ physiology.MethodsWe investigated the population, diversity, and abundance of endophytic bacteria in the leaves of three bamboo species—Phyllostachys edulis, Bambusa rigida, and Pleioblastus amarus—using high-throughput 16S rDNA sequencing.Results and discussionA total of 1,159 operational taxonomic units (OTUs) were obtained and further classified into 26 phyla, 64 classes, 158 orders, 270 families, 521 genera, and 811 species. The phyla with the highest abundance were Proteobacteria, Actinobacteria, and Myxococcota, and the highest genera included 1,174–901-12, Sphingomonas, and unclassified_f__Enterobacteriaceae. The relative richness of endophytic bacteria in the three species was in the following order: B. rigida &gt; P. amarus &gt; Ph. edulis. The PICRUSt functional richness analysis of endophytic bacteria indicated their involvement in six biological pathways: “cellular processes,” “environmental information processing,” “genetic information processing,” “human diseases,” “metabolism,” and “organic systems.” Among the 41 sub-functions, the most common were “amino acid metabolism,” “carbohydrate metabolism,” “cell motility,” “cellular signaling,” “energy metabolism,” and “membrane transport.” Our results provide precise knowledge for better managing bamboo forests and pave the way for isolating secondary metabolites and potential bioactive compounds.
Pasteurized Akkermansia muciniphila Timepie001 ameliorates DSS-induced ulcerative colitis in mice by alleviating intestinal injury and modulating gut microbiota
Authors: Han Huan , Xiong Hui , Liu Zengli , Liu Xunzhi , Wang Hailin , Kou Jiaxiang , Yi Dewei , Shi Ying , Wu Hao , Qiao Jianjun 
Published: February 2025

IntroductionAkkermansia muciniphila (A. muciniphila), known as a next-generation probiotic, has been widely recognized for its beneficial effects in various metabolic diseases. While there is not much research whether live or pasteurized A. muciniphila has different effects on intestinal health.MethodsIn the present study, a strain of A. muciniphila was isolated from healthy individuals, with the live and pasteurized A. muciniphila named Timepie001 and Timepie001+, respectively. They were administered to dextran sulfate sodium-induced ulcerative colitis mice to investigate their influences on the host intestinal health.Results and conclusionThe results showed that prophylactic supplementation with live and pasteurized A. muciniphila alleviates ulcerative colitis symptoms by retarding weight loss, preserving intestinal tissue structure, modulating inflammatory cytokines (TNF-α, IL-1β), and enhance the colonic mucosal barrier by upregulating the expression of tight junction protein Claudin-1. Interestingly, pasteurized A. muciniphila has a better effect compared with live A. muciniphila. Moreover, pasteurized A. muciniphila can regulates the gut microbiome to maintain intestinal homeostasis. This provides theoretical support for the widespread application of postbiotics in the food industry.
Talking during walking: the diagnostic potential of turn dynamics in Alzheimer’s disease, mild cognitive impairment and cognitive aging
Authors: Mohammadi Hedieh , Maghsoudpour Adel , Noroozian Maryam , Mohammadian Fatemeh 
Published: February 2025

BackgroundWhile gait analysis is well-documented, turn performance—which is a more complex task and involves multiple brain regions—has been less explored. This study aims to assess the diagnostic potential of turn dynamics as a novel tool for detecting cognitive decline.MethodsWe recruited 75 participants, including 26 neurotypical (NT) older adults, 25 with amnestic mild cognitive impairment (aMCI), and 24 with mild Alzheimer’s disease (AD). Participants completed a dual-task walk and turn (DTWT) test using a dual Kinect setup while counting backwards by ones. Key measures analyzed included spatial-temporal parameters of gait and turn dynamics. Statistical analyses including analyses of variance and linear regression were performed to identify key features as well as to assess their correlation with cognitive performance.ResultsGait speed and stride time significantly differentiated among groups in DTWT conditions. More notably, turn dynamics, particularly segmental peak speeds and step length, displayed stronger discriminatory power with more significant p-values compared to gait features. Linear regression analysis indicated that turn dynamics had stronger correlations with executive function and working memory, suggesting a more pronounced relationship between cognitive performance and turn features than gait variables.ConclusionIn contrast to straight walk metrics, this study shows that DTWT turn dynamics are more sensitive to detect cognitive impairment. Consequently, incorporating turning movements into gait analysis techniques could enhance diagnostic protocols in clinical settings, offering a valuable tool for monitoring the progression of conditions associated with cognitive aging.
20 Hz temporal interference stimulation can more effectively enhance motor evoked potentials in the primary motor cortex
Authors: Wang Yajie , Zhu Chunyue , Zhou Junhong , Fu Tianli , Yan Jinlong , Wang Bangyu , Lü Jiaojiao , Huang Lingyan , Liu Yu 
Published: February 2025

ObjectiveThis study investigates the effects of temporal interference stimulation (TI) with different envelope frequencies on the cortical excitability of the primary motor cortex (M1).MethodsIn this randomized, double-blind, crossover study, 26 participants completed four separate study visits. During these visits, they received 20 min of three types of TI (10, 20, and 40 Hz envelope frequency) and sham stimulation applied over M1 in a randomized order. Transcranial magnetic stimulation (TMS) was employed to assess motor-evoked potentials (MEP) and resting motor threshold (RMT) over the left M1 (ipsilateral area) and right M1 (contralateral area) before, immediately after, and 30 and 60 min after stimulation.ResultsThe blinding efficacy was excellent, and no severe side effects were reported. TI stimulation with varying envelope frequencies affected MEP differently; 20 Hz TI stimulation enhanced the MEP of the ipsilateral M1 with after-effects appearing at 60 min, and no significant differences were observed between the 10 or 20 Hz TI stimulation with sham groups. However, no significant changes in RMT were observed under any of the TI conditions.Conclusion20 Hz TI stimulation increased the cortical excitability of the ipsilateral M1, highlighting that frequency is an important factor in the modulatory effect of TI.
An action decoding framework combined with deep neural network for predicting the semantics of human actions in videos from evoked brain activities
Authors: Zhang Yuanyuan , Tian Manli , Liu Baolin 
Published: February 2025

IntroductionRecently, numerous studies have focused on the semantic decoding of perceived images based on functional magnetic resonance imaging (fMRI) activities. However, it remains unclear whether it is possible to establish relationships between brain activities and semantic features of human actions in video stimuli. Here we construct a framework for decoding action semantics by establishing relationships between brain activities and semantic features of human actions.MethodsTo effectively use a small amount of available brain activity data, our proposed method employs a pre-trained image action recognition network model based on an expanding three-dimensional (X3D) deep neural network framework (DNN). To apply brain activities to the image action recognition network, we train regression models that learn the relationship between brain activities and deep-layer image features. To improve decoding accuracy, we join by adding the nonlocal-attention mechanism module to the X3D model to capture long-range temporal and spatial dependence, proposing a multilayer perceptron (MLP) module of multi-task loss constraint to build a more accurate regression mapping approach and performing data enhancement through linear interpolation to expand the amount of data to reduce the impact of a small sample.Results and discussionOur findings indicate that the features in the X3D-DNN are biologically relevant, and capture information useful for perception. The proposed method enriches the semantic decoding model. We have also conducted several experiments with data from different subsets of brain regions known to process visual stimuli. The results suggest that semantic information for human actions is widespread across the entire visual cortex.
Sex-specific prognostic utility of the sarcopenia index in all-cause mortality risk for patients with heart failure
Authors: Li Ming , Liang Yanying , Wu Baozhen , Zhu Ziliang , Wang Meifang , Chen Jianying , Chen Can 
Published: February 2025

BackgroundThe sarcopenia index (SI), derived from serum creatinine and cystatin C levels, has emerged as a novel and accessible biomarker for predicting clinical outcomes. However, its sex-specific prognostic utility in heart failure (HF) remains poorly understood. This study aimed to investigate the association between SI and all-cause mortality in HF, with a focus on sex-specific differences.MethodsA retrospective cohort of 753 patients (median age: 69 years; 61% male) diagnosed with HF from a tertiary hospital in China was analyzed. Cox regression models and Kaplan–Meier survival analyses were utilized to evaluate the relationship between SI and all-cause mortality. Stratified analyses based on sex were performed, and the incremental predictive value of SI was assessed by integrating it into traditional risk models.ResultsOver a median follow-up of 537 days, 143 deaths occurred. In adjusted models, a lower SI was significantly associated with an increased risk of all-cause mortality in male patients (hazard ratio: 0.98 per unit increase, 95% confidence interval: 0.97–0.99, p = 0.002). Males in the lowest SI tertile had a 1.66-fold higher mortality risk than those in the highest tertile (p = 0.004). Kaplan–Meier survival analysis further confirmed these findings, demonstrating significantly lower survival probabilities for males in the lowest SI tertile than for those in higher tertiles (Log-rank p = 0.0013). No such association was observed in females. Adding SI to risk models improved prognostic accuracy in males, enhancing the C-statistic from 0.749 to 0.764 and significantly improving net reclassification and discrimination indices (p &lt; 0.05).ConclusionThe SI serves as a robust sex-specific predictor of all-cause mortality in HF, demonstrating significant prognostic value in males but limited utility in females. These findings highlight the potential of SI as a cost-effective addition to existing risk stratification models for male patients with HF.
Fecal microbiota transplantation improves hepatic steatosis induced by HFD in a mouse model associated with liver ILC1 regulation and indole-3-carbinol level
Authors: Hou Peng-fei , Yao Yu , Wu Ying , Yu Hong-tao , Qin Yu , Yi Long , Mi Man-tian 
Published: February 2025

BackgroundThe prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has increased worldwide. In recent years, fecal microbiota transplantation (FMT) has become an important promising method for the treatment of MASLD. However, the mechanism remains unclear.MethodsThe animal model with C57BL/6 male mice induced by high-fat diet (HFD) for 12 weeks has been introduced. Fecal microbiota and indole-3-carbinol (I3C) was given by oral gavage.ResultsOur study demonstrated that a 6-week healthy gut microbiota transplantation tended to ameliorate hepatic steatosis and reverse the decreased liver ILC1 induced by HFD. Interestingly, there was also a negative correlation between liver ILC1 and liver TG, TC level. Furthermore, the protective effect was associated with the elevated levels of serum indole-3-carbinol (I3C). Also, a I3C administration for 6 weeks improved liver steatosis and increased the frequency of liver ILC1 induced by HFD through aryl hydrocarbon receptor (AhR) activation. Moreover, I3C binds to the residues of ALA349, PHE348, LEU309, TYR316, PHE318 on AhR through hydrogen bonds, Π bonds, hydrophobic bonds which was proved by molecular docking.ConclusionTo conclude, our data demonstrated that FMT improved liver steatosis induced by HFD associated with liver ILC1 regulation and indole-3-carbinol level. The study highlighted the potential treatment value of FMT and microbiota-derived I3C in the MASLD treatment and regulation of liver ILC1 function.
Optimization of instant sweet osmanthus white tea: formulation, sensory evaluation, and antioxidant properties
Authors: Yang Yuhua , Fan Li , Lin Yiqin , Huang Yan , Zhang Jianming , Li Shaohua , Ma Chunhua , Cheng Xi , Koh Wee Yin , Tan Thuan-Chew 
Published: February 2025

ObjectiveThis study aims to optimize the formulation of instant sweet osmanthus white tea (IOWT) and evaluate its antioxidant activities through in vitro assays.MethodsSingle-factor and orthogonal experiments were conducted to investigate the impacts of sweet osmanthus-to-white tea ratio and the concentrations of β-cyclodextrin, erythritol, and citric acid on sensory properties and total flavonoids content (TFC) of IOWT. Mixtures of the dried ingredients were spray-dried to produce IOWT.Results and discussionThe optimal formulation of IOWT was as follows: sweet osmanthus-towhite tea ratio of 1:5, 4% β-cyclodextrin, 6% erythritol, and 0.5% citric acid. This optimized IOWT formulation obtained the highest sensory score of 89.5 and a TFC of 25.76%. Using ascorbic acid as a positive control, the in vitro antioxidant activities of the optimized IOWT formulation were assessed by measuring its ability to scavenge DPPH radicals, hydroxyl radicals, superoxide anion radicals, and ABTS radicals. At a concentration of 1.0 mg/mL, the optimized IOWT formulation exhibited scavenging rates of 88.01, 94.99, 97.57, and 99.11% against DPPH, hydroxyl radicals, superoxide anion radicals, and ABTS radicals, respectively, indicating strong in vitro antioxidant activities of IOWT. This study demonstrated promising potential for the development of novel white tea-based products.
Innovative functional juice enriched with native probiotics for enhanced nutrition and antimicrobial properties
Authors: Tenea Gabriela N. , Perugachi Erika 
Published: February 2025

IntroductionThe increasing demand for consuming highly nutritional value foods based on fruits or vegetables in combination with “beneficial” lactic acid bacteria (LAB) expands the research on developing novel functional non-diary delivery vectors.MethodsIn this study, the native Lactiplantibacillus plantarum UTNCys5-4 (Cys5-4) and commercial Lactiplantibacillus plantarum ATCC8014 (LP) strains have been targeted for probiotic properties in a novel designed tropical beverage containing yellow passionfruit (maracuyá) and coconut (MC). Furthermore, the quality of the newly fortified beverages, MCA (MC + Cys5-4) and MCB (MC + LP), was evaluated, along with their antimicrobial activity against two foodborne pathogens.ResultsThe results showed greater cell viability of Cys5-4 (8.84 ×107 CFU/ml), whereas a statistically significant (p &lt; 0.05) decrease was registered for LP strain (1.90 × 105 CFU/mL) on the 15th day of storage with refrigeration. An enhanced ascorbic acid content (AAC) and total polyphenol content (TPC) in both fortified juices (MCA and MCB), with MCA showing moderate TPC increases and MCB showing slightly higher improvements. Both fortified juices exhibited increased antioxidant capacity (AOX) compared to the non-fortified control (MC), emphasizing their enhanced functional value. An intrinsic inhibitory activity against Salmonella enterica subsp. enterica ATCC51741 and Escherichia coli ATCC25922 was observed in the MC juice during the first 6 days of storage, after which the activity was lost. In contrast, the inhibitory activity in both MCA and MCB juices increased up to 15 days of storage, suggesting a synergistic interaction between the antimicrobial compounds produced by the bacteria and those naturally present in the fruit, effectively enhancing their role as in situ antimicrobial agents. These findings validate the use of Cys5-4 as a promising probiotic strain for developing functional beverages with improved shelf life, sensory properties, and health-promoting benefits.ConclusionThe synergistic antimicrobial and antioxidant effects underscore the potential of combining probiotics with tropical fruits like yellow passionfruit and coconut for innovative and nutritionally valuable non-dairy food products. These formulations present a promising solution for delivering native LAB strains, enabling the fruit and dairy industries to create healthier, market-driven products.
Efficacy and prognosis biomarker of locally advanced ESCC patients treated with neoadjuvant chemotherapy and anti-PD-1 immunotherapy
Authors: Li Shuman , Zhou Jie , Wang Qianli , Chen Jiewei , Qi Yapeng 
Published: February 2025

IntroductionImmunotherapy has rapidly advanced in tumor treatment. In esophageal squamous cell carcinoma (ESCC), its use in neoadjuvant therapy has shown promising results. Several phase III clinical trials have confirmed that immunodetection site inhibitors in neoadjuvant therapy can enhance the pathologically complete response (pCR) rate.MethodsWe retrospectively analyzed 128 ESCC patients treated with neoadjuvant chemotherapy plus anti-PD-1 immunotherapy at the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital from July 2019 to November 2023.ResultsOf the 128 patients, 31 (24.1%) achieved pCR, and 46 (35.9%) achieved a major pathological response (MPR). Female patients, low-level tumor abnormal protein (TAP), and moderate differentiation were significantly associated with a higher pCR rate and MPR rate. Besides pCR rate and MPR rate, low-level TAP and moderate differentiation had significantly longer PFS and OS. The mean PFS in the low-level TAP group was 42.4 months, significantly longer than the 28.5 months in the high-level TAP group (p = 0.019). The mean OS in the low-level TAP group was 43.7 months, compared to 30.5 months in the high-level TAP group (p = 0.027). The multivariate analysis showed that TAP and differentiation were independent prognostic factors for PFS, and the pCR rate was an independent prognostic factor for OS in ESCC patients treated with anti-PD-1. Thus, lower TAP levels predict a better response to neoadjuvant chemotherapy plus anti-PD-1 immunotherapy in advanced ESCC patients. In clinical practice, serum TAP levels before neoadjuvant therapy can serve as a useful tool to predict the efficacy of this combined treatment.