bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations Between Autoimmune Conditions and Gastric Cancer Risk Among Elderly Adults in the United States
Authors: Song Minkyo , Camargo M. Constanza , Derkach Andriy , Rabkin Charles S. , Engels Eric A. 
Published: January 2022

INTRODUCTION:
Pernicious anemia (PA) is a risk factor for gastric cancer. Other autoimmune conditions may also contribute.

METHODS:
In a case-control study, we evaluated 47 autoimmune conditions among 39,125 gastric cancers and 200,000 cancer-free controls.

RESULTS:
Six conditions were associated with increased gastric cancer risk (range of adjusted odds ratios: 1.28–1.93, P < 0.05): PA, membranous nephropathy, primary biliary cirrhosis, pure red cell aplasia, primary sclerosing cholangitis, and Graves disease. PA was associated with 8 other autoimmune conditions (adjusted odds ratios: 1.57–4.54, P < 0.05).

DISCUSSION:
Autoimmune conditions associated with gastric cancer or PA may reflect effects of autoimmune gastritis or other carcinogenic pathways.
Antibiotic Therapy and Risk of Early-Onset Colorectal Cancer: A National Case-Control Study
Authors: Nguyen Long H. , Cao Yin , Batyrbekova Nurgul , Roelstraete Bjorn , Ma Wenjie , Khalili Hamed , Song Mingyang , Chan Andrew T. , Ludvigsson Jonas F. 
Published: January 2022

INTRODUCTION:
Antibiotic use has emerged as a risk factor for colorectal neoplasia and is hypothesized as a contributor to the rising incidence of colorectal cancer under age 50 years or early-onset colorectal cancer (EOCRC). However, the impact of antibiotic use and risk of EOCRC is unknown.

METHODS:
We conducted a population-based case-control study of CRC among individuals aged ≥18 years in the Epidemiology Strengthened by histoPathology Reports in Sweden (ESPRESSO) cohort (2006–2016). The primary outcome was EOCRC. A secondary outcome was CRC at any age. Incident CRC was pathologically confirmed, and for each, up to 5 population-based controls were matched on age, sex, county of residence, and calendar year. We assessed prescriptions until 6 months before CRC diagnosis. Conditional logistic regression was used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).

RESULTS:
We identified 54,804 cases of CRC (2,557 EOCRCs) and 261,089 controls. Compared with none, previous antibiotic use was not associated with EOCRC risk after adjustment for potential confounders (aOR 1.06, 95% CI: 0.96, 1.17) with similarly null findings when stratified by anatomic tumor site. In contrast, previous antibiotic use was weakly associated with elevated risk for CRC at any age (aOR 1.05, 95% CI: 1.02, 1.07). A potential but modest link between broad-spectrum antibiotic use and EOCRC was observed (aOR 1.13, 95% CI: 1.02, 1.26).

DISCUSSION:
We found no conclusive evidence that antibiotics are associated with EOCRC risk. Although antibiotic use was weakly associated with risk of CRC at any age, the magnitude of association was modest, and the study period was relatively short.
PENERAPAN GRADIENT BOOSTING DENGAN HYPEROPT UNTUK MEMPREDIKSI KEBERHASILAN TELEMARKETING BANK
Authors: Suryana Silvia Elsa , Warsito Budi , Suparti Suparti 
Published: January 2022

Telemarketing is another form of marketing which is conducted via telephone. Bank can use telemarketing to offer its products such as term deposit. One of the most important strategy to the success of telemarketing is opting the potential customer to create effective telemarketing. Predicting the success of telemarketing can use machine learning. Gradient boosting is machine learning method with advanced decision tree. Gardient boosting involves many classification trees which are continually upgraded from previous tree. The optimal classification result cannot be separated from the role of the optimal hyperparameter. Hyperopt is Python library that can be used to tune hyperparameter effectively because it uses Bayesian optimization. Hyperopt uses hyperparameter prior distribution to find optimal hyperparameter. Data in this study including 20 independent variables and binary dependent variable which has ‘yes’ and ‘no’ classes. The study showed that gradient boosting reached classification accuracy up to 90,39%, precision 94,91%, and AUC 0,939. These values describe gradient boosting method is able to predict both classes ‘yes’ and ‘no’ relatively accurate.
KLASIFIKASI REGRESI LOGISTIK MULTINOMIAL DAN FUZZY K-NEAREST NEIGHBOR (FK-NN) DALAM PEMILIHAN METODE KONTRASEPSI DI KECAMATAN BULAKAMBA, KABUPATEN BREBES, JAWA TENGAH
Authors: Rismia Erysta Risky , Widiharih Tatik , Santoso Rukun 
Published: January 2022

The characteristics of society in choosing contraceptive methods are also the crucial factors for the government to prepare the family planning services needed at Bulakamba District, Brebes Regency, Central Java. In this case, a classification process needs to be done to assist the process of classifying the characteristics of society in the selection of contraceptive methods. Multinomial Logistic Regression classification is good in exploring data information meanwhile Fuzzy K Nearest Neighbor (FK-NN) classification is good for handling big data and noise. These two methods used in this study because they are relevant to the data applied and will be compared their classification accuracy through APER and Press's Q calculations.The classification accuracy results obtained based on the APER calculation for Multinomial Logistic Regression is 88,25% and Fuzzy K Nearest Neighbor (FK-NN) is 88,92%. Meanwhile, the Press's Q value of both methods are 9600,945 and 9518,014 greater than χ 2𝛼,1 which is 3,841, so that it is statistically accurate. Based on the results obtained, it can be concluded that Multinomial Logistic Regression classification method has a better classification accuracy than Fuzzy K Nearest Neighbor (FK-NN) method.
IMPLEMENTASI R-SHINY UNTUK ANALISIS BIPLOT KOMPONEN UTAMA (Studi Kasus: Penggunaan Alat Kontrasepsi pada Peserta Aktif KB di Provinsi Jawa Tengah Tahun 2019)
Authors: Andreanto Andreanto , Yasin Hasbi , Rusgiyono Agus 
Published: January 2022

The population problem is a fairly complex and complicated problem. Therefore, Indonesia seeks to control the birth rate with the Family Planning program. The implementation of this program can be evaluated through statistical data. The statistical analysis used is biplot principal component analysis to see the relationship between districts/cities in choosing the contraceptive device/method used, the variance of each contraceptive device/method, the correlation between contraceptive devices/methods, and the superiority value of the contraceptive device/method in the population. each district/city. The problem with performing the analysis is the limitations of easy-to-use open source software. As with R, users must understand writing code to perform data analysis. Therefore, to perform a biplot analysis of the principal components, an RShiny application has been created using RStudio. The R-Shiny that has been made has many advantages, including complete results which include data display, data transformation, SVD matrix, to graphs along with plot graph interpretation. The results of the principal component biplot analysis using R-Shiny with α =1 have the advantage of a good principal component biplot, which is 95.63%. This shows that the biplot interpretation of the main components produced can be explained well the relationship between the district/city and the contraceptive methods/devices used.
On non-resistive limit of 1D MHD equations with no vacuum at infinity
Authors: Li Zilai , Wang Huaqiao , Ye Yulin 
Published: January 2022

Abstract
In this paper, the Cauchy problem for the one-dimensional compressible isentropic magnetohydrodynamic (MHD) equations with no vacuum at infinity is considered, but the initial vacuum can be permitted inside the region. By deriving a priori ν (resistivity coefficient)-independent estimates, we establish the non-resistive limit of the global strong solutions with large initial data. Moreover, as a by-product, the global well-posedness of strong solutions for the compressible resistive MHD equations is also established.
Impact of sports participation on components of metabolic syndrome in adolescents: ABCD growth study
Authors: Menezes Veronica Alves de , Torres Wesley , Mesquita Eduardo Duarte de Lima , Chagas Lucas Gabriel de Moraes , Morano Ana Elisa von Ah , Urban Jacqueline Bexiga , Avelar Ademar , Christofaro Diego Giuliano Destro , Fernandes Romulo Araujo 
Published: January 2022

Abstract

Objectives
This study aimed to analyze the impact of sports participation (12 months of practice) on the components of metabolic syndrome (MetS) in both sexes.

Methods
This is an observational longitudinal study, a part of which is entitled “Analysis of Behaviors of Children During Growth” (ABCD Growth Study), Presidente Prudente, São Paulo, Brazil. The sample was composed of 171 adolescents (112 boys and 59 girls), divided into non-sports and sports groups. High-density lipoprotein-cholesterol (HDL-c), triglycerides, and glucose were analyzed by the colorimetric method of dry chemistry and processed biochemically. Systolic blood pressure and diastolic blood pressure were measured using an automatic device. Body fat was estimated using a densitometry scanner.

Results
Adolescents who practiced sports were younger (p-value=0.001) and had a lower peak height velocity (p-value=0.001) than the non-sports group. The differences (Δ) after 12 months were of greater magnitude for the sports group when compared to the non-sports group (p-value=0.013), glucose (moderate magnitude in favor of the sports group; p-value=0.001), HDL-c (small magnitude in favor of the sports group; p-value=0.0015), and MetS (moderate magnitude in favor of the sports group; p-value=0.001).

Conclusions
The practice of sports in adolescents had a protective effect on the metabolic components of MetS.
Who needs prenatal counselling with a pediatric surgeon? Experience from a large tertiary care university hospital
Authors: Froeliger Alizée , Harper Luke , Tunon de Lara Sara , Lavrand Frédéric , Loot Maya , Lefevre Yan , Sentilhes Loïc , Coatleven Frédéric , Dobremez Éric 
Published: January 2022

Abstract

Objectives
To describe our experience with prenatal counselling for surgical anomalies in a large volume center. The secondary aim is to suggest a list of prenatal abnormalities warranting counselling by a pediatric surgeon.

Methods
We reviewed all prenatal counselling consultations performed by the pediatric surgery team between January 1st, 2015 and December 31st, 2016.

Results
A total of 169 patients or couples had a prenatal consultation with a pediatric surgeon. Prenatal work-up included a fetal MRI in 26% of cases, mainly for digestive and thoracic pathologies (56.1% of cases). Consultation with the pediatric surgeon led mainly to recommendations concerning the place of delivery. Induction for reasons related to the fetal anomaly occurred in 22.2% of cases. Most children were surgically treated within the first year of life (63.5%). Correlation between predicted prognosis and actual status at four years of life was 96.9%. Correlation between prenatal and postnatal diagnosis was 87.4%.

Conclusions
Prenatal counselling by a pediatric surgeon allows couples to obtain clear information on the pathology of their unborn child, giving them greater autonomy in their decision to continue the pregnancy.
The crystal structure of poly[diaqua-(μ2-1,2,4,5-tetrakis(1,2,4-triazol-1-ylmethyl)-benzene-κ2N:N′)-bis(μ3-terephthalato-κ3O:O′:O′′)dicadmium(II)], C17H15N6O5Cd
Authors: Wang Hua-Rui 
Published: January 2022

Abstract
C17H15N6O5Cd, monoclinic, P21/c (no. 14), a = 10.095(2) Å, b = 13.380(3) Å, c = 14.968(5) Å, β = 115.16(2)°, V = 1829.9(9) Å3, Z = 4, R

gt
(F) = 0.0267, wR

ref
(F
2) = 0.0602, T = 293(2) K.
Crystal structure of (μ4-(1,2,4,5-tetra(1,2,4-triazol-1-ylmethyl)-benzene-κ4
N:N1:N2:N3
)disilver(I) diperchlorate
Authors: Wang Hua-Rui 
Published: January 2022

Abstract
C9H9N6O4ClAg, monoclinic, C2/c (no. 15), a = 24.730(5) Å, b = 11.776(2) Å, c = 9.6860(19) Å, β = 109.09(3)°, V = 2665.6(9) Å3, Z = 8, R

gt
(F) = 0.0646, wR

ref
(F
2) = 0.2177, T = 293(2) K.
Investigations on the interaction between the front and aft purge flow and the downstream vane of 1.5-stage turbine
Authors: Zhenpeng He , Jiaxing Zhou , Jia Xin , Chengquan Yang , Baichun Li 
Published: January 2022

Abstract
The present work reports the influence of the 1.5-stage turbine flow field by the front and aft rim seal flow. The interaction between the front and aft purge flow and the mainstream of a 1.5-stage turbine was numerically simulated, and the influence of the front and aft purge flow on the downstream vane was analyzed separately. The results show that the front purge flow is distributed at the higher radius of second vane inlet, which changes the position of the blade hub secondary flows, and the aft purge flow is distributed at the low radius. The purge flow at different locations in the aft cavity exit forms shear induced vortex, pressure and suction side legs of the egress, which converges with the suction and pressure side legs of the horse vortex to form vane hub passage vortex. The increased purge flow rate in both the front and aft cavities significantly increases the sealing effectiveness of the rim seal, but also causes a reduction in turbine efficiency. The combined effect of the front and aft purge flow reduces the turbine efficiency of the end-wall structure by 0.3619, 0.9062, 1.5004, 2.0188 and 2.509% at IR = 0, IR = 0.5%, IR = 0.9%, IR = 1.3% and IR = 1.7%.
SARS-CoV-2 Gastrointestinal Shedding in Hospitalized Children
Authors: Tam Ivy , McNamara Courtney , Dunbar Julie , O’Connor Katherine , Manzano Gonzalo , Cabana Michael D. , Hametz Patricia A. 
Published: January 2022

BACKGROUND
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory virus that can cause gastrointestinal (GI) symptoms, with studies demonstrating detection of stool viral RNA weeks after respiratory tract clearance. It is unknown if children who test negative for SARS-CoV-2 on a nasopharyngeal (NP) swab may be shedding the virus in their stool.

OBJECTIVE
To measure the prevalence of SARS-CoV-2 stool shedding in children with positive and negative SARS-CoV-2 NP polymerase chain reactions (PCR) tests, and to determine clinical factors associated with GI shedding.

METHODS
In this cross-sectional study, we enrolled hospitalized patients 0 to 21 years old with a positive or a negative SARS-CoV-2 NP PCR test who had respiratory and/or GI symptoms. Participants were surveyed, and stool samples were sent for viral PCR testing. Fisher’s exact test was used to evaluate bivariate associations of stool PCR test positivity with categorical variables.

RESULTS
Sixty-seven patients were consented; 34 patients did not provide stool samples so 33 patients were included: 17 NP-positive and 16 NP-negative for SARS-CoV-2. Eight of the 17 NP-positive patients had a positive stool PCR test for SARS-CoV-2, while none of the 16 SARS-CoV-2 NP-negative patients had a positive result (P &lt; .01). For the 17 SARS-CoV-2 NP-positive patients, GI symptoms were associated with a positive stool PCR test (P = .05) for SARS-CoV-2, but this association was not found for all 33 patients (P = .11). No associations were found with patients in an immunocompromised state or those with a comorbid condition, fever and/or chills, respiratory symptoms, headache and/or myalgias, or anosmia and/or ageusia.

CONCLUSIONS
SARS-CoV-2 GI shedding is common and associated with GI symptoms in NP-positive children, with 47% having positive stool PCRs for SARS-CoV-2. GI shedding was not demonstrated in SARS-CoV-2 NP-negative children.
Reducing Unnecessary Respiratory Viral Testing to Promote High-Value Care
Authors: Ostrow Olivia , Savlov Deena , Richardson Susan E. , Friedman Jeremy N. 
Published: January 2022

BACKGROUND AND OBJECTIVES
Viral respiratory infections are common in children, and practice guidelines do not recommend routine testing for typical viral illnesses. Despite results often not impacting care, nasopharyngeal swabs for viral testing are frequently performed and are an uncomfortable procedure. The aim of this initiative was to decrease unnecessary respiratory viral testing (RVT) in the emergency department (ED) and the pediatric medicine wards (PMWs) by 50% and 25%, respectively, over 36 months.

METHODS
An expert panel reviewed published guidelines and appropriate evidence to formulate an RVT pathway using plan-do-study-act cycles. A multifaceted improvement strategy was developed that included implementing 2 newer, more effective tests when testing was deemed necessary; electronic order modifications with force functions; audit and feedback; and education. By using statistical process control charts, the outcomes analyzed were the percentage of RVT ordered in the ED and the rate of RVT ordered on the PMWs. Balancing measures included return visits leading to admission and inpatient viral nosocomial outbreaks.

RESULTS
The RVT rate decreased from a mean of 3.0% to 0.5% of ED visits and from 44.3 to 30.1 per 1000 patient days on the PMWs and was sustained throughout the study. Even when accounting for the new rapid influenza test available in the ED, a 50% decrease in overall ED RVT was still achieved without any significant impact on return visits leading to admission or inpatient nosocomial infections.

CONCLUSIONS
Through implementation of a standardized, electronically integrated RVT pathway, a decrease in unnecessary RVT was successfully achieved. Audit and feedback, reminders, and biannual education all supported long-term sustainability of this initiative.
Home Health Care Utilization in Children With Medicaid
Authors: Sobotka Sarah A. , Hall David E. , Thurm Cary , Gay James , Berry Jay G. 
Published: January 2022

BACKGROUND
Although many children with medical complexity (CMC) use home health care (HHC), little is known about all pediatric HHC utilizers. Our objective was to assess characteristics of pediatric HHC recipients, providers, and payments.

METHODS
We conducted a retrospective analysis of 5 209 525 children age 0-to-17 years enrolled Medicaid in the 2016 IBM Watson MarketScan Medicaid Database. HHC utilizers had ≥ 1 HHC claim. Healthcare Common Procedure Coding System (HCPCS) and Current Procedural Terminology (CPT) codes were reviewed to codify provider types when possible: registered nurse (RN), licensed practical nurse (LPN), home health aide (HHA), certified nursing assistant (CNA), or companion/personal attendant. Enrollee clinical characteristics, HHC provider type, and payments were assessed. Chronic conditions were evaluated with Agency for Healthcare Research and Quality’s Chronic Condition Indicators and Feudtner’s Complex Chronic Conditions.

RESULTS
Of the 0.8% of children who used HHC, 43.8% were age &lt;1 year, 25% had no chronic condition, 38.6% had a noncomplex chronic condition, 21.5% had a complex chronic condition without technology assistance, and 15.5% had technology assistance (eg, tracheostomy). HHC for children with technology assistance accounted for 72.6% of all HHC spending. Forty-five percent of HHC utilizers received RN/LPN-level care, 7.9% companion/personal attendant care, 5.9% HHA/CNA-level care, and 36% received care from an unspecified provider. For children with technology assistance, the majority (77.2%) received RN/LPN care, 17.5% companion/personal assistant care, and 13.8% HHA/CNA care.

CONCLUSIONS
Children using HHC are a heterogeneous population who receive it from a variety of providers. Future investigations should explore the role of nonnurse caregivers, particularly with CMC.
The heritage of the League of Nations’ minority protection system
Authors: Scheu Harald Christian 
Published: January 2022

AbstractThis paper discusses the system of minority protection of the League of Nations. Minority protection occupied a prominent place on the League’s agenda, which developed a significant expertise in the field. The League’s system of minority protection is often regarded as an experiment. With regard to both material and procedural aspects this assessment is certainly correct. In particular, minority protection based upon legally binding treaties and declarations gave rise to the question of how individual and group rights should be treated within the frame of an international political organization. The paper further examines whether at least some of the elements of the League’s minority protection system still persist in the context of contemporary international human rights law.
A CONCEPÇÃO DE FREGE SOBRE “SENTIDO” E “REFERÊNCIA” COMO INFLUÊNCIA NO ESTUDO DA FILOSOFIA DA LINGUAGEM
Authors: De Melo Máximo Gustavo Rodríguez 
Published: January 2022

Este artigo tem como objetivo expor e discutir as concepções de Gottlob Frege sobre os conceitos de “sentido” e “referência” e como, por meio destes, se deu a contribuição do filósofo ao que hoje chamamos filosofia da linguagem. Entretanto, vários estudiosos não consideram Frege um autêntico filósofo da linguagem, alguns de seus escritos representam, historicamente, enorme influência nesse ramo da filosofia contemporânea, pois tentam solucionar certos problemas da linguagem. Serão analisados principalmente o célebre artigo “Sobre Sentido e Referência” bem como alguns de seus escritos que se ocupam, ainda que de modo secundário, sobre ambos os conceitos.
MICHEL FOUCAULT E A GOVERNAMENTALIDADE BRASILEIRA EM TEMPOS DE CORONAVÍRUS
Authors: De Oliveira Manoel Rufino David , Monteiro Vitória De Oliveira 
Published: January 2022

O presente artigo busca compreender o conceito de biopolítica na teoria de Michel Foucault e avaliar sua importância para analisar o contexto da gestão política quanto à andemia do coronavírus no Brasil. Em primeiro lugar, será discutida a biopolítica na obra “Microfísica do Poder” e sua relação com as políticas brasileiras de gestão em saúde em face do coronavírus. Posteriormente, será examinada como o sentido de biopolítica na obra “Emdefesa da sociedade” se relaciona com o genocídio do povo negro e pobre. Em seguida, serão analisadas a obra “A Vontade de Saber” e as biopolíticas anti feministas no contexto dessa pandemia. Em quarto lugar, será compreendido o sentido de biopolítica em “Território e População” e sua relação com as estatística s e o isolamento social. Por fim, será abordado o conceito de biopolítica em “Nascimento da biopolítica” e sua relação com agovernamentalidade neoliberal durante a pandemia do coronavírus.
​Determination of Serogroup and Lytic Activities of Bacteriophages Isolated from Phage Plaques in Staphylococcus aureus Cultures Identified from Sheep Milk with Mastitis
Authors: Gürbilek Sevil Erdenliğ , Arserim Neval Berrin , Tel Osman Yaşar , Sertkaya Zeynep , Keskin Oktay 
Published: January 2022

Backgorund: Bacteriophages are closely related to the evolution and virulence of some important bacterial pathogens. Due to their highly significant roles in pathogenesis and virulence, S. aureus bacteriophages are frequently studied. Bacteriophages are grouped into two main categories depending on their life cycles. There are highly consistently lytic phages (virulent) and temperate phages. This study aimed to isolate bacteriophages and determine their phage serogroups from phage plaques in S. aureus cultures in order to show if they are lytic or lysogenic, the latter plays a major role in horizontal gene transfer. Methods: A total of 234 S. aureus isolates were recovered from milk samples from cases with gangrenous mastitis in sheep. Staphylococcal phages are determined based on the type and serogroup by PCR using specific primers. Result: Our study allowed us to determine serogroups of the isolated bacteriophages. Two phage stock samples included only one serogroup while the others included more than one phage serotypes and needed further purification Fa, L and D serogroups were not determined in the study. Present work revealed that all the isolated phages were temperate phages, which play a highly significant role in horizontal gene transfer.