bluuebunny/crossref_metadata_2025_split huggingface dataset:
Darcy Tetreault, Cindy McCulligh y Carlos Lucio (coords). Despojo, conflictos socioambientales y alternativas en México
Authors: Madrigal González David 
Published: March 2022

Darcy Tetreault, Cindy McCulligh y Carlos Lucio (coordinadores) (2019). Despojo, conflictos socioambientales y alternativas en México.Universidad Autónoma de Zacatecas y Miguel Ángel Porrúa. 456 pp.
DOI: https://dx.doi.org/10.21696/rcsl102120201214
Thomas Calvo. Espacios, climas y aventuras: el galeón de Filipinas y la fragata de las Marianas en el Pacifico occidental (1680-1700)
Authors: Ibáñez Cruz Tania Leticia 
Published: March 2022

El libro que se reseña es Espacios, climas y aventuras: El galeón de Filipinas y la fragata de las Marianas en el Pacifico occidental (1680-1700), del doctor Thomas Calvo. La investigación que desarrolló el autor fue a través de las embarcaciones Santo Cristo de Burgos, Santo Niños, Nuestra Señora de Guía, San José, y San Francisco Xavier, ya que cada una navegó en el océano Pacifico durante los últimos veinte años del siglo XVII, momento en el que se presentó una “mini glaciación”.
El historiador analiza los diversos factores que afectaron a los navíos en el mar abierto, que van desde las cuestiones climáticas como el ENOS (fenómeno meteorológico también conocido como “El Niño”, que se presenta en el océano Pacifico), hasta las acciones humanas que determinaron el destino de los galeones.
En la reseña también se evalúa si la obra puede ubicarse dentro de la Historia Ambiental debido a la constante mención de las condiciones climáticas que se desarrollaron en el Pacifico a finales del siglo XVII.
Thomas Calvo (2016). Espacios, climas y aventuras: el galeón de Filipinas y la fragata de las Marianas en el Pacífico occidental (1680-1700). El Colegio de San Luis. DOI: 10.21696/rcsl10212020122111
Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic
Authors: Chavda Vivek P. , Patel Chirag , Modh Dharti , Ertas Yavuz Nuri , Sonak Shreya S. , Munshi Nafesa K. , Anand Krishnan , Soni Arun , Pande Sonal 
Published: March 2022

Abstract:Amyotrophic Lateral Sclerosis (ALS) is a terminal neuro-degenerative disorder that is clinically recognized as a gradual degeneration of the upper and lower motor neurons, with an average duration of 3 to 5 years from initial of symptoms to death. The mechanisms underlying the pathogenesis and progression of the disease are multifactorial. Therefore, to find effective treatments, it is necessary to understand the heterogeneity underlying the progression of ALS. Recent developments in gene therapy have opened a new avenue to treat this condition, especially for the characterized genetic types. Gene therapy methods have been studied in various pre-clinical settings and clinical trials, and they may be a promising path for developing an effective and safe ALS cure. A growing body of evidence demonstrates abnormalities in metabolic energy at the cellular and whole-body level in animal models and people living with ALS. Using and incorporatig high-throughput "omics" methods have radically transformed our thoughts about ALS, strengthened our understanding of the disease's dynamic molecular architecture, differentiated distinct patient subtypes, and created a reasonable basis for identifying biomarkers and novel individualised treatments. Future clinical and laboratory trials would also focus on the diverse relationships between metabolism and ALS to address the issue of whether targeting poor metabolism in ALS is an effective way to change disease progression. In this review, we focus on the detailed pathogenesis of ALS and highlight principal genes, i.e., SOD1, TDP-43, C9orf72, and FUS, as well as targeted ALS therapies. An attempt is made to provide up-to-date clinical outcomes, including various biomarkers that are thought to be important players in early ALS detection.
Recent Investigations on the Functional Role of Cerebellar Neural Networks in Motor Functions & Nonmotor Functions -Neurodegeneration
Authors: Nikolenko Vladimir N. , Sinelnikov Mikhail Y. , Beeraka Narasimha M. , Khaidarovich Zakirov F. , Valikovna Oganesyan M. , Aliagayevna Rizaeva N. , Arturovna Zharashueva L. , Alexandrovich Krasilnikov A. , Mikhaleva Liudmila M. 
Published: March 2022

Abstract:The cerebellum is a well-established primary brain center in charge of controlling sensorimotor functions and non-motor functions. Recent reports depicted the significance of cerebellum in higher-order cognitive functions, including emotion-processing, language, reward-related behavior, working memory, and social behavior. As it can influence diverse behavioral patterns, any defects in cerebellar functions could invoke neuropsychiatric diseases as indicated by the incidence of alexithymia and induce alterations in emotional and behavioral patterns. Furthermore, its defects can trigger motor diseases, such as ataxia and Parkinson’s disease (PD). In this review, we have extensively discussed the role of cerebellum in motor and non-motor functions and how the cerebellum malfunctions in relation to the neural circuit wiring as it could impact brain function and behavioral outcomes in patients with neuropsychiatric diseases. Relevant data regarding cerebellar non-motor functions have been vividly described, along with anatomy and physiology of these functions. In addition to the defects in basal ganglia, the lack of activity in motor related regions of the cerebellum could be associated with the severity of motor symptoms. All together, this review delineates the importance of cerebellar involvement in patients with PD and unravels a crucial link for various clinical aspects of PD with specific cerebellar sub-regions.
N-substitution Reactions of 2-Aminobenzimidazoles to Access Pharmacophores
Authors: Cruz Alejandro , Padilla-Martínez Itzia I. , García-Báez Efrén V. , Rosales-Hernández Martha C. , Mendieta Wejebe Jessica E. 
Published: March 2022

Abstract:
Benzimidazole (BI) and its derivatives are interesting molecules in medicinal
chemistry because several of these compounds have a diversity of biological activities and some
of them are even used in clinical applications. In view of the importance of these compounds,
synthetic chemists are still interested in finding new procedures for the synthesis of these classes
of compounds. Astemizole (antihistaminic), Omeprazole (antiulcerative), and Rabendazole
(fungicide) are important examples of compounds used in medicinal chemistry containing BI
nuclei. It is interesting to observe that several of these compounds contain 2-aminobenzimidazole
(2ABI) as the base nucleus. The structures of 2ABI derivatives are interesting because they have
a planar delocalized structure with a cyclic guanidine group, which have three nitrogen atoms
with free lone pairs and labile hydrogen atoms. The 10-π electron system of the aromatic BI ring
conjugated with the nitrogen lone pair of the hexocyclic amino group, making these heterocycles
to have an amphoteric character. Synthetic chemists have used 2ABI as a building block to
produce BI derivatives as medicinally important molecules. In view of the importance of the BIs,
and because no review was found in the literature about this topic, we reviewed and summarized
the procedures related to the recent methodologies used in the N-substitution reactions of 2ABIs
by using aliphatic and aromatic halogenides, dihalogenides, acid chlorides, alkylsulfonic
chlorides, carboxylic acids, esters, ethyl chloroformates, anhydrides, SMe-isothioureas, alcohols,
alkyl cyanates, thiocyanates, carbon disulfide and aldehydes or ketones to form Schiff bases. The
use of diazotized 2ABI as intermediate to obtain 2-diazoBIs was included to produce Nsubstituted
2ABIs of pharmacological interest. Some commentaries about their biological activity
were included.
Adsorption of Ammonium Ion from Tofu Industrial Liquid Waste by Coconut Shell-Activated Carbon
Authors: Adha C. N. , Istiqomah U. , Safitri A. W. , Tarmini T. 
Published: March 2022

Liquid waste from tofu industry will flow or discharge into water. It causes pollution which is characterized by unpleasant odor. If this continues, it can damage the environment and threaten the health of the people who inhale the unpleasant odor. Activated carbon is a carbon that is able to adsorb in the liquid phase or gas phase. Activated carbon is the best adsorbent in the adsorption system. The material for activated carbon comes from animals, plants, and waste or minerals that contain carbon. Coconut shell is an ingredient that can be made into activated carbon. Activated carbon from coconut shell has many benefits one of them can adsorb liquid waste from tofu industry. This study aims to examine the ability of coconut shell to adsorben, that have been activated by K2CO3 or HCl activator. In this study given the variation of activated charcoal mass and contact time variations to determine the effect on the ability of activated coconut shell charcoal adsorption on ammonia content in Liquid waste from tofu industry. The results of this study are the greater the mass of activated charcoal and the longer the contact time, the greater the ammonia absorbed by activated charcoal, which indicates that the percent decrease in ammonia concentration is greater
Exploring learning and behavior problems of gifted children in Indonesia: A content analysis study
Authors: Pujaningsih Pujaningsih , Alfi Mar’atu Husnia 
Published: March 2022

Although gifted children have talents and positive traits in academic area that already been supported, little empirical evidence addresses the need of support for gifted children in non-academic areas in Indonesian context. To fill this void, this study conducted a content analysis of two books about gifted children based on parents’ narratives to explore the need for support for social-emotional problems. “Menyongsong Pagi” and “Menyiangi Petang” are the two books which describe how thirteen gifted children grew up and face obstacle in their learning. Drawing on the theory of positive disintegration and Bronfenbrenner’s theory of ecological development, this study analyzed the two books to describe the uniqueness of gifted students in terms of emotion, intellectual and psychomotor still mostly seen as problems by their teachers and friends which lead to various educational issues. The implication of this study calls for the comprehensive support from teachers and schools’ leader to support gifted children both in academic and non-academic areas.
KETERLIBATAN PERSATOEAN PERKOEMPOELAN KAOEM BOEROEH (PPKB) DALAM GERAKAN BURUH DI JAWA 1919-1921
Authors: Yasin Ahmad 
Published: March 2022

AbstrakKaum buruh bergerak mencari saluran aspirasi akan kondisi kerja lewat serikat buruh pada awal abad ke-20. Akhir 1919, sebagian serikat berhimpun dalam sebuah federasi bernama Persatoean Perkoempoelan Kaoem Boeroeh (PPKB). Tujuan penelitian ini adalah menjelaskan pertumbuhan serikat buruh di Jawa awal abad ke-20, pengaruh pembentukan PPKB dalam gerakan buruh, dan dampak keretakan PPKB bagi gerakan buruh. Penelitian ini menggunakan metode sejarah dengan melalui empat tahap, yaitu heuristik, kritik sumber, interpretasi, dan historiografi. Hasil dari penelitian menunjukkan pertumbuhan serikat buruh menandai kaum buruh menyalurkan aspirasinya secara terorganisir. Pertumbuhan gerakan buruh dilirik organisasi politik yang menghasilkan usaha menyatukan kekuatan serikat dalam PPKB. PPKB berpengaruh saat mengawal pemogokan buruh percetakan di Semarang pada awal 1920, tetapi kemudian federasi ini terkendala operasional organisasi dan tertekan oleh konflik internal. Konflik meretakkan PPKB yang berdampak bagi perpecahan federasi ini pada 1921. Kata kunci: PPKB, Gerakan, Jawa
Cost-effectiveness of Web-Based and Home-Based Postnatal Psychoeducational Interventions for First-time Mothers: Economic Evaluation Alongside Randomized Controlled Trial
Authors: Zheng Qishi , Shi Luming , Zhu Lixia , Jiao Nana , Chong Yap Seng , Chan Sally Wai-Chi , Chan Yiong Huak , Luo Nan , Wang Wenru , He Honggu 
Published: March 2022

Background
The cost-effectiveness of interventions has attracted increasing interest among researchers. Although web-based and home-based psychoeducational interventions have been developed to improve first-time mothers’ postnatal health outcomes, very limited studies have reported their cost-effectiveness.

Objective
The aim of this study was to evaluate the cost-effectiveness of web-based and home-based postnatal psychoeducational interventions for first-time mothers during the early postpartum period.

Methods
A randomized controlled 3-group pretest and posttest design was adopted, and cost-effectiveness analysis from the health care’s perspective was conducted. A total of 204 primiparas were recruited from a public tertiary hospital in Singapore from October 2016 to August 2017 who were randomly allocated to the web-based intervention (n=68), home-based intervention (n=68), or control (n=68) groups. Outcomes of maternal parental self-efficacy, social support, postnatal depression, anxiety, and health care resource utilization were measured using valid and reliable instruments at baseline and at 1 month, 3 months, and 6 months after childbirth. The generalized linear regression models on effectiveness and cost were used to assess the incremental cost-effectiveness ratios of the web-based and home-based intervention programs compared to routine care. Projections of cumulative cost over 5 years incurred by the 3 programs at various coverage levels (ie, 10%, 50%, and 100%) were also estimated.

Results
The web-based intervention program dominated the other 2 programs (home-based program and routine care) with the least cost (adjusted costs of SGD 376.50, SGD 457.60, and SGD 417.90 for web-based, home-based, and control group, respectively; SGD 1=USD 0.75) and the best improvements in self-efficacy, social support, and psychological well-being. When considering the implementation of study programs over the next 5 years by multiplying the average cost per first-time mother by the estimated average number of first-time mothers in Singapore during the 5-year projection period, the web-based program was the least costly program at all 3 coverage levels. Based on the 100% coverage, the reduced total cost reached nearly SGD 7.1 million and SGD 11.3 million when compared to control and home-based programs at the end of the fifth year, respectively.

Conclusions
The web-based approach was promisingly cost-effective to deliver the postnatal psychoeducational intervention to first-time mothers and could be adopted by hospitals as postnatal care support.

Trial Registration
ISRCTN registry ISRCTN45202278; https://www.isrctn.com/ISRCTN45202278
SIMULTANEOUS METHOD DEVELOPMENT AND VALIDATION OF CHOLINE SALICYLATE AND TANNIC ACID USING RP-HPLC IN BULK AND PHARMACEUTICAL DOSAGE FORM
Authors: RAJU M. DAVID 
Published: March 2022

Objective: The current investigation was pointed at completely unique and reliable high performance liquid chromatographic method for simultaneous quantification of Choline salicylate and Tannic acid.
Methods: Chromatographic separation was achieved on a symmetry C18 column (150x4.6mm, 3.5 µ) using isocratic elution with a buffer containing 1 ml of OPA in l lt of HPLC marked water and acetonitrile within the percentage of 60:40 as movable phase with a flow rate of 1.0 ml/min at ambient temperature. Analysis was achieved within 15 min over an honest linearity within the concentration range from 4-60 µg/ml of choline salicylate and 2.5-37.5 µg/ml of tannic acid. Stress conditions of degradation in acidic, alkaline, peroxide and thermal was studied.
Results: LOD and LOQ were observed as 1.21 µg/ml, 0.758 µg/ml and 4 µg/ml, 2.5 µg/ml of choline salicylate and tannic acid respectively. Precision and recovery study results were found to be within the suitable limit.
Conclusion: This developed method showed reliable, precise, accurate results under optimized conditions. The method was validated as reported by ICH guidelines. Hence it was evident that the proposed method was suitable for regular analysis and quality control of pharmaceutical preparations.
The Effect of Organizational Communication and Organizational Justice on Employee Job Satisfaction at Kapal Garden Hotel Malang
Authors: Ratnasari Defi , Mohyi Achmad , Nurhasanah Siti 
Published: March 2022

The purpose of this study was to determine the influence of organizational communication and organizational justice on employees' job satisfaction at Kapal Garden Hotel Malang. The population and sample on this study were all hotel employees totaling 30 people using a sampling technique, namely saturated sampling. Data collection techniques were using questionnaires and interviews. The data analysis method used was a scale range and multiple linear regression analysis. The results of this study indicated that the calculation of the organizational communication scale range showed good results, organizational justice shows fair results, and job satisfaction showed satisfactory results. The results of the regression analysis showed that organizational communication had a positive and significant effect on employees' job satisfaction. And organizational justice influenced positively and significantly towards employees' job satisfaction.
Postinfectious Irritable Bowel Syndrome: Polemic and Open Issues
Authors: Sheptulin A. A. , Vize-Khripunova M. A. 
Published: March 2022

Aim. An analysis of polemic and open topics in epidemiology, pathogenesis, clinic, diagnosis and treatment of postinfectious irritable bowel syndrome (IBS).Key points. The incidence of postinfectious IBS links to aetiological factors underlying the development of acute infectious gastroenteritis (bacteria, viruses or protozoans). The risk factors of postinfectious IBS have been identified: female gender, excessive anxiety, depression and somatisation, a severe sequence of acute infectious gastroenteritis, etc. The diagnosis of postinfectious IBS implies exclusion of organic diseases with similar clinical presentations. A specific postinfectious IBS treatment is currently lacking and adheres to non-postinfectious IBS strategies.Conclusion. The postinfectious IBS problematic is poorly understood and requires further research.
THE IMPACT OF MOODLE-BASED LEARNING MANAGEMENT SYSTEMS (LMS) ON LEARNING ACHIEVEMENT IN THE COVID-19 PANDEMIC
Authors: Yugo Febry Kristianggoro , Hendriana Heris , Afrilianto Muhammad 
Published: March 2022

Abstract Since the COVID-19 pandemic ravaged the world, tutor-student meetings have been hampered. This issue also contributes to the learning process requiring students' autonomy, which means that it will be difficult to have techniques and the role of technology in the world of education now and in the future. The purpose of this study was to evaluate the findings of a learning evaluation that involved remote learning via e-learning modules and a Moodle-based Learning Management System (LMS). The two-sample dependent t-test was administered to 30 students in class 12 A at PKBM Darul Fiqri, Cimahi City, using the SPSS 22.0 application. The study's findings indicate that this learning module may have an effect on students' overall achievement. Keywords: Learning Module, E-learning, Learning Management System (LMS), Moodle, Pandemic COVID-19 Abstrak Sejak adanya pandemi COVID-19 yang melanda dunia, maka pertemuan antara tutor dan warga belajar menjadi terhambat. Isu ini juga yang membuat proses pembelajaran menuntut adanya kemandirian para warga belajar, sehingga hal ini juga akan menjadi tantangan masa kini dan tantangan di masa depan untuk memiliki teknik dan mengedepankan peran teknologi dalam dunia pendidikan. Tujuan penelitian ini adalah untuk menganalisis hasil evaluasi warga belajar dalam penggunaan pembelajaran jarak jauh melalui modul pembelajaran e-learning dengan Learning Management System (LMS) berbasis Moodle. Metode penelitian ini adalah kuantitatif melalui Uji T Dua Sampel Dependent dengan menggunakan aplikasi SPSS 22.0 kepada 30 orang warga belajar dari kelas 12 A di PKBM Darul Fiqri Kota Cimahi. Hasil penelitian menunjukkan bahwa pada umumnya modul pembelajaran ini dapat memberikan pengaruh terhadap prestasi warga belajar. Kata kunci: Modul Pembelajaran, E-learning, Learning Management System (LMS), Moodle, Pandemic COVID-19
PENGARUH PROGRAM UNDIAN BERHADIAH UMRAH DAN CITRA MEREK TERHADAP MINAT BELI DI ASSALAAM HYPERMARKET KARTASURA
Authors: Tri Aryanto Ardi Wahyu , Raqib Muhammad 
Published: March 2022

This study aims to analyze the effect of the Umrah prize lotteryÂ program and brand image towardÂ buying interest inÂ Assalaam Hypermarket Kartasura. The dependent variable in this study is buying interest. Meanwhile, the independent variables are theÂ Umrah prizeÂ lotteryÂ and brand image. The population in this study included the entire population of the Kartasura sub-district as many as 109,549. The sample was selected byÂ usingÂ the accidental sampling method andÂ the Slovin formula with an error rate of 10% and obtained 100 respondents. This studyÂ was a quantitative study using multiple linear regression as an analysis technique. The results show that the Umrah prize lottery affects buying interest. Furthermore,Â brand image affects buying interest. And finally, the Umrah prizeÂ lotteryÂ and brand image affectÂ buying interest.
PENGARUH SIKAP, NORMA SUBJEKTIF DAN KENDALI PERILAKU TERHADAP NIAT KEPATUHAN PEGAWAI IAIN SURAKARTA DALAM MEMBAYAR ZAKAT
Authors: Mahardika Mei Candra 
Published: March 2022

Zakat is an obligation for Muslims who have more wealth. The results of the study in 2011 by BAZNAS and FEM IPB found the fact that the potential for zakat in Indonesia reached 217 trillion, while from that potential couldÂ only collect 1.729 trillion. This study usedÂ the planned behaviour theoryÂ fromÂ Ajzein and Fizbein which statesÂ attitudes, subjective norms, and behavioral control have a relationship with the intention. The studyÂ formulation lookedÂ at the determinants of IAIN Surakarta employeesâ€™Â intentions in payingÂ zakat. This studyÂ usedÂ a quantitative approach with a survey method using a questionnaire instrument. The population in thisÂ study wereÂ 445 employes of IAIN Surakarta.Â TheÂ samplesÂ of the study wereÂ 159 employes who were alreday civil servants.Â The data analysis techniques wereÂ quantitative descriptive and inferential descriptive.Â The result of the studyÂ explainedÂ that there wasÂ a relationshipÂ between attitudes, subjective norm, and behavioural control with the intention of IAIN Surakarta employeesÂ in paying zakat. Behaviour control has the highest relationshipÂ withÂ intention. The behaviour in paying zakat carried out by IAIN Surakarta employees cannot be separated from the role of institution that use internal policies to encourage their employees to carry outÂ zakat obligations. The existence of the Zakat Management Unit (UPZ) facilitates the collection and management of zakat from IAIN Surakarta employees themselves. The influence of co-workers also increases the understanding of religion,Â especially the obligation of zakat for employees who have civil servant status, because their income has reached nisab (limit) to payÂ zakat.