bluuebunny/crossref_metadata_2025_split huggingface dataset:
Normative values of non-invasively assessed RV function and pulmonary circulation coupling for pre-participation screening derived from 497 male elite athletes
Authors: Bauer Pascal , Tello Khodr , Kraushaar Lutz , Dörr Oliver , Keranov Stanislav , Husain-Syed Faeq , Nef Holger , Hamm Christian W. , Most Astrid 
Published: September 2022

Abstract
Background
Reference values for right ventricular function and pulmonary circulation coupling were recently established for the general population. However, normative values for elite athletes are missing, even though exercise-related right ventricular enlargement is frequent in competitive athletes.

Methods
We examined 497 healthy male elite athletes (age 26.1 ± 5.2 years) of mixed sports with a standardized transthoracic echocardiographic examination. Tricuspid annular plane excursion (TAPSE) and systolic pulmonary artery pressure (SPAP) were measured. Pulmonary circulation coupling was calculated as TAPSE/SPAP ratio. Two age groups were defined (18–29 years and 30–39 years) and associations of clinical parameters with the TAPSE/SPAP ratio were determined and compared for each group.

Results
Athletes aged 18–29 (n = 349, 23.8 ± 3.5 years) displayed a significantly lower TAPSE/SPAP ratio (1.23 ± 0.3 vs. 1.31 ± 0.33 mm/mmHg, p = 0.039), TAPSE/SPAP to body surface area (BSA) ratio (0.56 ± 0.14 vs. 0.6 ± 0.16 mm*m2/mmHg, p = 0.017), diastolic blood pressure (75.6 ± 7.9 vs. 78.8 ± 10.7 mmHg, p < 0.001), septal wall thickness (10.2 ± 1.1 vs. 10.7 ± 1.1 mm, p = 0.013) and left atrial volume index (27.5 ± 4.5 vs. 30.8 ± 4.1 ml/m2, p < 0.001), but a higher SPAP (24.2 ± 4.5 vs. 23.2 ± 4.4 mmHg, p = 0.035) compared to athletes aged 30–39 (n = 148, 33.1 ± 3.4 years). TAPSE was not different between the age groups. The TAPSE/SPAP ratio was positively correlated with left ventricular stroke volume (r = 0.133, p = 0.018) and training amount per week (r = 0.154, p = 0.001) and negatively correlated with E/E′ lat. (r = −0.152, p = 0.005).

Conclusion
The reference values for pulmonary circulation coupling determined in this study could be used to interpret and distinguish physiological from pathological cardiac remodeling in male elite athletes.
Paclitaxel drug-coated balloon-only angioplasty for de novo coronary artery disease in elective clinical practice
Authors: Merinopoulos Ioannis , Gunawardena Tharusha , Corballis Natasha , Bhalraam U , Gilbert Tim , Maart Clint , Richardson Paul , Ryding Alisdair , Sarev Toomas , Sawh Chris , Sulfi Sreekumar , Wickramarachchi Upul , Wistow Trevor , Mohamed Mohamed O. , Mamas Mamas A. , Vassiliou Vassilios S. , Eccleshall Simon C. 
Published: September 2022

Abstract
Objective
We aimed to investigate the safety of drug-coated balloon (DCB)-only angioplasty compared to drug-eluting stent (DES), as part of routine clinical practice.

Background
The recent BASKETSMALL2 trial demonstrated the safety and efficacy of DCB angioplasty for de novo small vessel disease. Registry data have also demonstrated that DCB angioplasty is safe; however, most of these studies are limited due to long recruitment time and a small number of patients with DCB compared to DES. Therefore, it is unclear if DCB-only strategy is safe to incorporate in routine elective clinical practice.

Methods
We compared all-cause mortality and major cardiovascular endpoints (MACE), including unplanned target lesion revascularisation (TLR) of all patients treated with DCB or DES for first presentation of stable angina due to de novo coronary artery disease between 1st January 2015 and 15th November 2019. Data were analysed with Cox regression models and cumulative hazard plots.

Results
We present 1237 patients; 544 treated with DCB and 693 treated with DES for de novo, mainly large-vessel coronary artery disease. On multivariable Cox regression analysis, only age and frailty remained significant adverse predictors of all-cause mortality. Univariable, cumulative hazard plots showed no difference between DCB and DES for either all-cause mortality or any of the major cardiovascular endpoints, including unplanned TLR. The results remained unchanged following propensity score-matched analysis.

Conclusion
DCB-only angioplasty, for stable angina and predominantly large vessels, is safe compared to DES as part of routine clinical practice, in terms of all-cause mortality and MACE, including unplanned TLR.

Graphic abstract
A CHCHD6–APP axis connects amyloid and mitochondrial pathology in Alzheimer’s disease
Authors: Shang Yutong , Sun Xiaoyan , Chen Xiaoqin , Wang Quanqiu , Wang Evan J. , Miller Emiko , Xu Rong , Pieper Andrew A. , Qi Xin 
Published: September 2022

AbstractThe mechanistic relationship between amyloid-beta precursor protein (APP) processing and mitochondrial dysfunction in Alzheimer’s disease (AD) has long eluded the field. Here, we report that coiled-coil-helix-coiled-coil-helix domain containing 6 (CHCHD6), a core protein of the mammalian mitochondrial contact site and cristae organizing system, mechanistically connects these AD features through a circular feedback loop that lowers CHCHD6 and raises APP processing. In cellular and animal AD models and human AD brains, the APP intracellular domain fragment inhibits CHCHD6 transcription by binding its promoter. CHCHD6 and APP bind and stabilize one another. Reduced CHCHD6 enhances APP accumulation on mitochondria-associated ER membranes and accelerates APP processing, and induces mitochondrial dysfunction and neuronal cholesterol accumulation, promoting amyloid pathology. Compensation for CHCHD6 loss in an AD mouse model reduces AD-associated neuropathology and cognitive impairment. Thus, CHCHD6 connects APP processing and mitochondrial dysfunction in AD. This provides a potential new therapeutic target for patients.
Mechanochemical Models for Calcium Waves in Embryonic Epithelia
Authors: Kaouri Katerina , Méndez Paul E. , Ruiz-Baier Ricardo 
Published: September 2022

AbstractIn embryogenesis, epithelial cells acting as individual entities or as coordinated aggregates in a tissue, exhibit strong coupling between mechanical responses to internally or externally applied stresses and chemical signalling. One of the most important chemical signals in this process is calcium. This mechanochemical coupling and intercellular communication drive the coordination of morphogenetic movements which are characterised by drastic changes in the concentration of calcium in the tissue. In this paper we extend the recent mechanochemical model in Kaouri et al. (J. Math. Biol.78, 2059–2092, 2019), for an epithelial continuum in one dimension, to a more realistic multi-dimensional case. The resulting parametrised governing equations consist of an advection-diffusion-reaction system for calcium signalling coupled with active-stress linear viscoelasticity and equipped with pure Neumann boundary conditions. We implement a finite element method in perturbed saddle-point form for the simulation of this complex multiphysics problem. Special care is taken in the treatment of the stress-free boundary conditions for the viscoelasticity in order to eliminate rigid motions from the space of admissible displacements. The stability and solvability of the continuous weak formulation is shown using fixed-point theory. Guided by the bifurcation analysis of the one-dimensional model, we analyse the behaviour of the system as two bifurcation parameters vary: the level of IP3concentration and the strength of the mechanochemical coupling. We identify the parameter regions giving rise to solitary waves and periodic wavetrains of calcium. Furthermore, we demonstrate the nucleation of calcium sparks into synchronous calcium waves coupled with deformation. This model can be employed to gain insights into recent experimental observations in the context of embryogenesis, but also in other biological systems such as cancer cells, wound healing, keratinocytes, or white blood cells.
Pattern of lymph node metastases in gastric cancer: a side-study of the multicenter LOGICA-trial
Authors: de Jongh Cas , Triemstra Lianne , van der Veen Arjen , Brosens Lodewijk A. A. , Luyer Misha D. P. , Stoot Jan H. M. B. , Ruurda Jelle P. , van Hillegersberg Richard ,   the LOGICA Study Group, Brenkman Hylke J. F. , Seesing Maarten F. J. , Nieuwenhuijzen Grard A. P. , Ponten Jeroen E. H. , Tegels Juul J. W. , Hulsewe Karel W. E. , Wijnhoven Bas P. L. , Lagarde Sjoerd M. , de Steur Wobbe O. , Hartgrink Henk H , Kouwenhoven Ewout A. , van Det Marc J , Wassenaar Eelco B , van Duijvendijk P. , Draaisma Werner A. , Broeders Ivo A. M. J. , van der Peet Donald L. , Gisbertz Suzanne S. 
Published: September 2022

AbstractBackgroundThe relation between gastric cancer characteristics and lymph node (LN) metastatic patterns is not fully clear, especially following neoadjuvant chemotherapy (NAC). This study analyzed nodal metastatic patterns.MethodsIndividual LN stations were analyzed for all patients from the LOGICA-trial, a Dutch multicenter randomized trial comparing laparoscopic versus open D2-gastrectomy for gastric cancer. The pattern of metastases per LN station was related to tumor location, cT-stage, Lauren classification and NAC.ResultsBetween 2015–2018, 212 patients underwent D2-gastrectomy, of whom 158 (75%) received NAC. LN metastases were present in 120 patients (57%). Proximal tumors metastasized predominantly to proximal LN stations (no. 1, 2, 7 and 9;p < 0.05), and distal tumors to distal LN stations (no. 5, 6 and 8; OR > 1,p > 0.05). However, distal tumors also metastasized to proximal LN stations, and vice versa. Despite NAC, each LN station (no. 1–9, 11 and 12a) showed metastases, regardless of tumor location, cT-stage, histological subtype and NAC treatment, including station 12a for cT1N0-tumors. LN metastases were present more frequently in diffuse versus intestinal tumors (66% versus 52%;p = 0,048), but not for cT3–4- versus cT1–2-stage (59% versus 51%;p = 0.259). However, the pattern of LN metastases was similar for these subgroups.ConclusionsThe extent of lymphadenectomy cannot be reduced after NAC for gastric cancer. Although the pattern of LN metastases is related to tumor location, all LN stations contained metastases regardless of tumor location, cT-stage (including cT1N0-tumors), histological subtype, or NAC treatment. Therefore, D2-lymphadenectomy should be routinely performed during gastrectomy in Western patients.
New Software for DQE Calculation in Digital Mammography Compliant with IEC 62220–1-2
Authors: Dobrzyńska Magdalena , Wysocka-Rabin Anna , Fabiszewska Ewa , Pasicz Katarzyna , Skrzyński Witold 
Published: September 2022

AbstractSignificant improvements in mammography systems have been achieved with the introduction of active matrix flat-panel digital detectors. The advent of this technology also makes it possible to implement computational methods for quantitative image analysis. This study describes new software created to perform detective quantum efficiency (DQE) calculations fully compliant with the IEC 62220–1-2 standard. Python-based software was developed that contains modules to calculate inverse conversion function, modulation transfer function (MTF), noise power spectrum (NPS), and DQE itself. A graphical user interface (GUI) and further add-ons make this software more user-friendly. Results are immediately displayed diagrammatically, and complete output data are exported to a .csv file. The code is available freely, as a compiled, executable file (.exe). The program was successfully tested using DICOM images obtained from mammography units from different manufacturers. This study also includes validation of the new software, based on comparisons of results obtained for the same set of data with two other, freely available programs.
A densely interconnected network for deep learning accelerated MRI
Authors: Ottesen Jon André , Caan Matthan W. A. , Groote Inge Rasmus , Bjørnerud Atle 
Published: September 2022

Abstract
Objective
To improve accelerated MRI reconstruction through a densely connected cascading deep learning reconstruction framework.

Materials and methods
A cascading deep learning reconstruction framework (reference model) was modified by applying three architectural modifications: input-level dense connections between cascade inputs and outputs, an improved deep learning sub-network, and long-range skip-connections between subsequent deep learning networks. An ablation study was performed, where five model configurations were trained on the NYU fastMRI neuro dataset with an end-to-end scheme conjunct on four- and eightfold acceleration. The trained models were evaluated by comparing their respective structural similarity index measure (SSIM), normalized mean square error (NMSE), and peak signal to noise ratio (PSNR).

Results
The proposed densely interconnected residual cascading network (DIRCN), utilizing all three suggested modifications achieved a SSIM improvement of 8% and 11%, a NMSE improvement of 14% and 23%, and a PSNR improvement of 2% and 3% for four- and eightfold acceleration, respectively. In an ablation study, the individual architectural modifications all contributed to this improvement for both acceleration factors, by improving the SSIM, NMSE, and PSNR with approximately 2–4%, 4–9%, and 0.5–1%, respectively.

Conclusion
The proposed architectural modifications allow for simple adjustments on an already existing cascading framework to further improve the resulting reconstructions.
LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis
Authors: Lu Mingming , Gao Qing , Wang Yafei , Ren Jie , Zhang Tingting 
Published: September 2022

Abstract
Background
Long non-coding RNA (lncRNA) exhibits a crucial role in multiple human malignancies. The expression of lncRNA LINC00511, reportedly, is aberrantly up-regulated in several types of tumors. Our research was aimed at deciphering the role and mechanism of LINC00511 in the progression of cervical cancer (CC).

Method
Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to quantify the expression levels of LINC00511, miR-497-5p and MAPK1 mRNA in CC tissues and cell lines. Cell counting kit-8 (CCK-8), 5-bromo-2’-deoxyuridine (BrdU) and Transwell assays were conducted for detecting the proliferation, migration and invasion of CC cells. Dual-luciferase reporter gene experiments were performed to verify the targeting relationships amongst LINC00511, miR-497-5p and MAPK1. Besides, MAPK1 expression in CC cells was detected via Western blot after LINC00511 and miR-497-5p were selectively regulated.

Results
Up-regulation of LINC00511 expression in CC tissues and cell lines was observed, which was in association with tumor size, clinical stage and lymph node metastasis of the patients. LINC00511 overexpression facilitated the proliferation, migration and invasion of CC cells, while opposite effects were observed after knockdown of LINC00511. Mechanistically, LINC00511 was capable of targeting miR-497-5p and up-regulating MAPK1 expression.

Conclusion
LINC00511/miR-497-5p/MAPK1 axis regulates CC progression.
Neurological Consequences, Mental Health, Physical Care, and Appropriate Nutrition in Long-COVID-19
Authors: Picone Pasquale , Sanfilippo Tiziana , Guggino Rossella , Scalisi Luca , Monastero Roberto , Baschi Roberta , Mandalà Valeria , San Biagio Livio , Rizzo Manfredi , Giacomazza Daniela , Dispenza Clelia , Nuzzo Domenico 
Published: September 2022

AbstractSARS-CoV-2 pandemic has caused a collapse of the world health systems. Now, vaccines and more effective therapies have reversed this crisis but the scenario is further aggravated by the appearance of a new pathology, occurring as SARS-CoV-2 infection consequence: the long-COVID-19. This term is commonly used to describe signs and symptoms that continue or develop after acute infection of COVID-19 up to several months. In this review, the consequences of the disease on mental health and the neurological implications due to the long-COVID are described. Furthermore, the appropriate nutritional approach and some recommendations to relieve the symptoms of the pathology are presented. Data collected indicated that in the next future the disease will affect an increasing number of individuals and that interdisciplinary action is needed to counteract it.
Nocardia infection following ocular surface surgery
Authors: Wang Jingting , Lu Xiuhai , Wang Jungang , Wang Shuting , Shi Weiyun , Li Suxia 
Published: September 2022

Abstract
Objective
To investigate the clinical characteristics and treatment outcomes of Nocardia infection after ocular surface surgery.

Methods
This is a retrospective study. Eight cases of culture-proven Nocardia infection, which developed within 1 month after ocular surface surgery were included. Demographics and clinical history of patients were investigated.

Results
There were 8 eyes (2 left and 6 right) of 8 patients (5 males and 3 females), aged 27–65, with a median age of 52.9 years. Three cases underwent pterygium excision, three were subjected to conjunctival flap covering, and two were treated with lamellar corneal transplantation. The time interval between previous surgery and the onset of symptoms varied from 7 to 28 days (mean = 20.5 ± 7.13 days). All the cases presented grey-white infiltrates at the surgical incision site while appearing with six corneal ulcers and two conjunctival ulcers. Filaments of Nocardia were founded by confocal microscopy in two of the five cases. All responded poorly to medical therapy. Seven of the eight cases were treated with reoperation. Nocardia infection recurred in three cases after reoperation, and one was eviscerated.

Conclusions
Surgical trauma is a risk factor for ocular Nocardia infection. Nocardia infection should be suspected when secondary infection occurs in a surgical incision with an atypical clinical presentation. The use of corticosteroids may influence the efficacy of drugs. Complete removal of lesions may lower the recurrence of Nocardia infection with poor drug treatment effects.
Economic potential and management of tropical mixed-species plantations in Central America
Authors: Pinnschmidt Arne , Yousefpour Rasoul , Nölte Anja , Murillo Olman , Hanewinkel Marc 
Published: September 2022

AbstractTropical forest plantations play an important role in meeting global wood demand. While research has highlighted the ecological potential of mixed-species plantations, studies on the economic viability and management of such plantations are largely missing in the context of tropical plantation forestry. In this study, we estimated the economic potential and optimized the management of commercial mixed-species plantations of four tree species native to Central America (Dalbergia retusa, Dipteryx oleifera, Hieronyma alchorneoides, and Vochysia guatemalensis) and Teak (Tectona grandis). We combined the forest growth model 3-PGmix and detailed economic data for two plantation sites in Costa Rica to optimize the management of 11 different mixtures using a genetic optimization algorithm. We found that several of the modeled mixed-species stands can be highly profitable with net present values (NPV) up to 4821.2 USD/ha at an 8% discount rate, and internal rates of return up to 17% (under excellent site conditions). This indicates that the most profitable mixtures (e.g. of V. guatemalensis-D. oleifera or T. grandis-D. oleifera on excellent sites) could compete economically with conventional monoculture plantations such as Teak monocultures. Further, mixed stands can be managed based on the same simple even-aged management approaches currently applied in monoculture plantations if the specific management parameters are adapted. The optimized management parameters also lead to improved NPV of the modeled stands under alternative valuation assumptions but are site-specific. In the present study, we only considered financial benefits from timber production. However, establishing mixed-species plantations in the tropics could provide a wide range of ecosystem services including climate change mitigation and biodiversity protection.
Financial Development, Political Instability, Trade Openness and Growth in Brazil: Evidence from a New Dataset, 1890-2003
Authors: Campos Nauro , Glebkina Ekaterina , Karanasos Menelaos , Koutroumpis Panagiotis 
Published: September 2022

AbstractWhat is the relationship between financial development, political instability, trade openness and economic growth and how does it change over time? This paper examines these links using a new econometric approach and unique data set. In this paper, we apply the logistic smooth transition model (LST) to annual data for Brazil from 1890 to 2003. The main finding is that financial development has a time-varying effect on economic growth, which depends significantly on (jointly estimated) trade openness thresholds. In addition, political instability displays a negative effect on growth whereas trade openness a positive one. Finally, our estimates show that in 56% of the years in which financial development has a ‘below the mean’ effect, we find that trade openness experiences a substantial ‘above the mean’ change.
Motivation and Feelings of Competence Among University Students in Introductory Physics
Authors: Romero-Abrio Ana , Hurtado-Bermúdez Santiago 
Published: September 2022

Abstract
This work analyzes whether there is a cognitive bias between the ideal perception of the skills and the real performance in an introductory physics class, and additionally, whether predictions of students’ performance are related to various motivational variables. We examined through a validated survey and network analysis the relationship between several motivational aspects and volitional variables with the accuracy of their predictions. The results show that the students present a motivational bias when students’ desires were considered, mainly in the students with low academic performance. Finally, it is necessary to explore the development of specific interventions that target the motivations of students, in order to be effective, and to reduce the gap between expected and actual grades, increasing students’ metacognitive skills and thus their academic performance.
On Identifying and Mitigating Bias in Inferred Measurements for Solar Vector Magnetic-Field Data
Authors: Leka K. D. , Wagner Eric L. , Griñón-Marín Ana Belén , Bommier Véronique , Higgins Richard E. L. 
Published: September 2022

AbstractThe problem of bias, meaning over- or under-estimation, of the component perpendicular to the line-of-sight [$B_{\perp }$

B
⊥

] in vector magnetic-field maps is discussed. Previous works on this topic have illustrated that the problem exists; here we perform novel investigations to quantify the bias, fully understand its source(s), and provide mitigation strategies. First, we develop quantitative metrics to measure the $B_{\perp }$

B
⊥

bias and quantify the effect in both local (physical) and native image-plane components. Second, we test and evaluate different options available to inversions and different data sources, to systematically characterize the impacts of these choices, including explicitly accounting for the magnetic fill fraction [$f\!\!f$
f
f
]. Third, we deploy a simple model to test how noise and different models of the bias may manifest. From these three investigations we find that while the bias is dominantly present in under-resolved structures, it is also present in strong-field, pixel-filling structures. Noise in the spectropolarimetric data can exacerbate the problem, but it is not the primary cause of the bias. We show that fitting $f\!\!f$
f
f
explicitly provides significant mitigation, but that other considerations such as the choice of $\chi ^{2}$

χ
2

-weights and optimization algorithms can impact the results as well. Finally, we demonstrate a straightforward “quick fix” that can be applied post facto but prior to solving the $180^{\circ}$

180
∘

ambiguity in $B_{\perp }$

B
⊥

, and which may be useful when global-scale structures are, e.g., used for model boundary input. The conclusions of this work support the deployment of inversion codes that explicitly fit $f\!\!f$
f
f
or, as with the new neural-net, that are trained on data that did so.