bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ankylosing spondylitis occurring in a patient with Behçet disease after chronic brucellosis infection: A case report and review of the literature
Authors: Yilmaz Ebru 
Published: November 2022

AbstractBehçet disease and ankylosing spondylitis are rarely seen together. This report presents a rare case of ankylosing spondylitis occurring in a patient with Behçet disease after chronic brucellosis infection. Infectious agents have long been considered one of the triggers for autoimmune and autoinflammatory diseases. Therefore, rheumatic processes should be kept in mind, especially in treatment‐resistant cases.
The opioid epidemic: A worldwide exploratory study using the WHO pharmacovigilance database
Authors: Robert Marion , Jouanjus Emilie , Khouri Charles , Fouilhé Sam‐Laï Nathalie , Revol Bruno 
Published: November 2022

AbstractBackground and AimsThe current opioid epidemic in the United States began 20 years ago and has become the leading cause of accidental deaths in the country. This crisis prompted us to explore trends in opioid abuse and dependence worldwide. We sought to identify other countries at high‐risk of opioid use disorders, using the World Health Organization's (WHO) pharmacovigilance database.MethodsWe performed a disproportionality analysis using VigiBase, the WHO Global Individual Case Safety Report (ICSR) database. Five opioids used worldwide were included: oxycodone, fentanyl, morphine, tramadol, and codeine. We extracted all ICSRs associated with the drugs of interest, considered as suspect medication and recorded up until 5 June 2021, using the narrow Standardised MedDRA Query (SMQ) for drug abuse and dependence. Countries with at least one ICSR for each of the five opioids were retained. The relationship between the use of a drug (i.e. an opioid) and the occurrence of an adverse drug reaction (i.e. drug abuse and dependence) for each country was assessed by calculating the information component (IC) and its 99.9% CI [IC0005; IC9995], using a quasi‐Bayesian confidence propagation neural network (BCPNN). A hierarchical cluster analysis (Ward's method) of the IC0005 value for each of the five opioids was performed to identify subgroups of countries with similar reported risks of opioid abuse and dependence.ResultsAmong 21 countries, the optimal number of clusters was calculated to be four, each with a Jaccard index >0.5 (0.95, 0.78, 0.65 and 0.75, respectively). Six countries with the highest signals of drug abuse and dependence were identified in cluster 1, with significant CIs for the five opioids of interest (IC0005 > 0), ranging from 0.9 to 5.8 for the lower endpoint.ConclusionsThere appear to be four distinct clusters of countries with similar opioid abuse and dependence profiles. The group with the highest reported risk for the opioids oxycodone, fentanyl, morphine, tramadol and codeine includes Australia, Canada, France, Germans, the United Kingdom and the United States.
Morphological features of the Egyptian Ossimi sheep tongue: New scanning electron microscopic insights into its papillary system adaptations to Egyptian ecological conditions
Authors: Abumandour Mohamed M. A. , Morsy Kareem , Elghoul Mahmoud 
Published: November 2022

AbstractThe current study aims to illustrate the gross and scanning electron microscopic characterizations and ultrastructural adaptation of the lingual papillary system of Egyptian Ossimi sheep to Egyptian ecological conditions. The tongue had three regions: the apex (with a slightly bifurcated tip), the body (subdivided into rostral and caudal parts) and the root (subdivided into rostral papillary and caudal non‐papillary parts). Torus linguae had two parts: the triangular rostral part (the caudal part of the body) and the quadrilateral wide part (the rostral part of the root). The lingual papillary system had mechanical (filiform, conical and lentiform) and gustatory (fungiform and circumvallate) types. Filiform papillae were heavily scattered on the dorsal surface of the apex, the rostral part of the body and the ventral surface of the papillary region of the tip. Filiform papillae had five subtypes (ventral and dorsal processed, triangular, leaf‐like and triangular‐processed papillae), while the conical papillae had three subtypes: two lingual (small, large) and one paralingual (elongated pointed), and the fungiform had two subtypes: the high‐density ovoid (on the ventral surface of the tip) and round papillae (on the dorsal surface) that possessed a high number of taste pores, not previously described. They ranged from 5 to 10 for ovoid and 25 to 25 for round papillae. Each circumvallate papilla had an ovoid bulb (with 2–5 taste pores) encircled by an annular groove and two pads (i.e. not described previously). The papillary system's regional divergence was specialized for their harsh and semi‐harsh diet.
Incidence of iron deficiency Anaemia during pregnancy in Far North Queensland
Authors: Carter Edward , Lane Katie , Ryan Elizabeth , Jayaratnam Skandarupan 
Published: November 2022

AbstractIntroductionThe WHO estimates the incidence of iron deficiency anaemia in Australia is 25%. However there is considerable variation during pregnancy and in regional areas.ObjectiveThe aim of this investigation is to quantify the incidence of iron deficiency anaemia during pregnancy within Far North Queensland.DesignThis is a single‐centre retrospective cohort study. Cairns Hospital is the main referral centre for complex maternity care in Far North Queensland with an estimated population of 280‐000, which includes many people from rural and remote communities and a high proportion who identify as Aboriginal or Torres Strait Islander. This study included all births at the Cairns Hospital in 2018, a total of 2190 deliveries.FindingsThe study randomly sampled 551 mothers from the cohort, and the incidence of iron deficiency anaemia was 34.9%. 48.7% of women who identified as Aboriginal or Torres Strait Islander within the region were anaemic. This was significantly higher than an incidence of 28.9% for the rest of the population. Other risk factors include booking appointment after 28‐weeks, Asian ethnicity and age less than 25‐years. A BMI greater than 35 was protectiveDiscussionThis study will inform antenatal care providers within the region and improve obstetric outcomes by increasing awareness. Identifying risk factors will also facilitate prompt treatment and improve maternity care for vulnerable patient groups. On a broader level, the study provides new data to inform population health estimates both nationally and internationally.ConclusionThe incidence of iron deficiency anaemia during pregnancy in Far North Queensland is significantly higher than previous estimates.
Women in urology: Gender differences in urologists' authorship in high impact journals
Authors: Demir Demirhan Örsan , Karagöz Mehmet Ali 
Published: November 2022

AbstractBackgroundThe number of women among medical doctors and surgeons continues to rise. However, urology remains one of the least preferred specialties by female physicians, resulting in the inadequate academic representation of female urologists. In this study we examined changes in the representation of female urologists in the journals European Urology (EU) and Journal of Urology (JOU) and investigated in which urology subspecialties female urologists focus their academic studies.MethodsOriginal articles, reviews and case reports published in EU and JOU were included in the study. The analysis was limited to 4 years, starting with 2004 and continuing at 5‐year intervals until 2019.The publications were also classified according to urology subspecialty and geographic location.ResultsIn total, 2708 articles were analysed. Overall, women accounted for 9.9% of first authors (267/2708) and 5.9% of senior authors (161/2708).The proportion of female first authors was 8.2% in 2004 and increased to 10.7% in 2009, 10.6% in 2014, and 11.6% in 2019 (P = 0.062). The proportion of female last authors was 7% in 2004 and 5.3%, 6.1%, and 2.5% in 2009, 2014, and 2019, respectively (P = 0.011). Women accounted for a significantly higher proportion of first authors than men in publications related to female and paediatric urology (P = 0.001 and P = 0.002, respectively).ConclusionsThe increasing number of women urologists worldwide is not reflected in the scientific authorship of female urologists. Multicenter studies focusing on the elimination of gender disparity in academic representation are needed in surgical branches such as urology.
Online activities for individuals with intellectual disabilities at a day centre in the wake of COVID‐19
Authors: Engwall Kristina 
Published: November 2022

Accessible summary
Many day centres in Sweden closed during the COVID‐19 pandemic.
Some day centres provided online activities like FaceTime calls and short films instead.
This was to help people keep in touch.
Some people with intellectual disabilities also got involved in making films when lockdown lifted.
People with intellectual disabilities and staff learned a lot about doing things online and using technology. It would be good to keep this going.
Exploring effects of an early math intervention: The importance of parent–child interaction
Authors: Ribner Andrew , Silver Alex M. , Elliott Leanne , Libertus Melissa E. 
Published: November 2022

AbstractWe explore whether training parents' math skills or playing number games improves children's mathematical skills. Participants were 162 parent–child dyads; 88.3% were white and children (79 female) were 4 years (M = 46.88 months). Dyads were assigned to a number game, shape game, parent‐only approximate number system training, parent‐only general trivia, or a no‐training control condition and asked to play twice weekly for 8 weeks. Children in the number game condition gained over 15% SD on an assessment of mathematical skill than did those in the no‐training control. After 8 additional weeks without training, effects diminished; however, children of parents in the ANS condition underperformed those in the no‐treatment control, which was partially explained by changes in the home numeracy environment.
The concept of family: Perspectives of Spanish young people in foster care
Authors: Ie Judite 
Published: November 2022

AbstractThis article employs concepts from family sociology to explore how ‘family’ is conceptualised in 14 life narratives of young people in foster care in Spain. The article draws on a multi‐method approach with young people who are in long‐term non‐kinship foster care. Seven girls and seven boys aged 10 to 22 took part in the study. The empirical material reveals an interplay between biological preference and foster family affective practices in young people's narratives, illuminating a struggle to make sense of the concept of family in foster care. Most of the participants understand family as shared affective practices sustained through love, commitment, consistent care and reciprocity rather than blood ties. Some show a preference for biological connectivity, while others describe family as determined by rituals and family displays. The key practice implications highlight the importance helping young people positioning themselves in birth family relationships, and supporting their sense of family belonging.
A NR2E1‐interacting peptide of LSD1 inhibits the proliferation of brain tumour initiating cells
Authors: Hu Rong , Hameed Umar Farook Shahul , Sun Xiang , Moorthy Balakrishnan Shenbaga , Zhang Wen , Jeffrey Philip D. , Zhou Li , Ma Xin , Chen Fangjin , Pei Jianfeng , Giri Pankaj K. , Mou Yonggao , Swaminathan Kunchithapadam , Yuan Ping 
Published: November 2022

AbstractObjectivesElimination of brain tumour initiating cells (BTICs) is important for the good prognosis of malignant brain tumour treatment. To develop a novel strategy targeting BTICs, we studied NR2E1(TLX) involved self‐renewal mechanism of BTICs and explored the intervention means.Materials and MethodsNR2E1 and its interacting protein‐LSD1 in BTICs were studied by gene interference combined with cell growth, tumour sphere formation, co‐immunoprecipitation and chromatin immunoprecipitation assays. NR2E1 interacting peptide of LSD1 was identified by Amide Hydrogen/Deuterium Exchange and Mass Spectrometry (HDX‐MS) and analysed by in vitro functional assays. The in vivo function of the peptide was examined with intracranial mouse model by transplanting patient‐derived BTICs.ResultsWe found NR2E1 recruits LSD1, a lysine demethylase, to demethylate mono‐ and di‐methylated histone 3 Lys4 (H3K4me/me2) at the Pten promoter and repress its expression, thereby promoting BTIC proliferation. Using Amide Hydrogen/Deuterium Exchange and Mass Spectrometry (HDX‐MS) method, we identified four LSD1 peptides that may interact with NR2E1. One of the peptides, LSD1‐197‐211 that locates at the LSD1 SWIRM domain, strongly inhibited BTIC proliferation by promoting Pten expression through interfering NR2E1 and LSD1 function. Furthermore, overexpression of this peptide in human BTICs can inhibit intracranial tumour formation.ConclusionPeptide LSD1‐197‐211 can repress BTICs by interfering the synergistic function of NR2E1 and LSD1 and may be a promising lead peptide for brain tumour therapy in future.
The vaccine hesitancy continuum among hesitant adopters of the COVID‐19 vaccine
Authors: Moore Ramey , Purvis Rachel S. , Willis Don E. , Worley Kyle C. , Hervey Devonte , Reece Sharon , Yeates Aimee , McElfish Pearl A. 
Published: November 2022

AbstractVaccination is a strategy for mitigating the impact of coronavirus disease 2019 (COVID‐19) at both the individual and population levels. Vaccine hesitancy is identified as a significant threat to global health by the World Health Organization (WHO). Vaccine hesitancy has been theorized as a continuum encompassing a range of attitudes, beliefs, emotional orientations, ideologies, and health‐seeking behaviors. Individuals who received the COVID‐19 vaccine but also indicated some level of hesitancy about vaccination, or “hesitant adopters,” remain an understudied group. This study uses a qualitative descriptive design to understand motivations to receive the COVID‐19 vaccine among hesitant adopters at various self‐reported levels of hesitancy. We conducted interviews with hesitant adopters (n = 49) to analyze the elements of vaccine hesitancy corresponding to reported levels of COVID‐19 vaccine hesitancy (i.e., “little hesitant,” “somewhat hesitant,” and “very hesitant”). Concerns about side effects are shared across the continuum but are articulated differently at each level of hesitancy. The “little hesitant” relate fears of side effects to their health and a lack of clear information to inform their health decision making, whereas the “very hesitant” articulate the risks of side effects within the frame of conspiracies related to the development, approval, and economics of the COVID‐19 vaccine. Additionally, conspiracy theories generally increase in salience across the continuum, with the “very hesitant” reporting conspiracy theories as the most salient element of vaccine hesitancy. This research presents opportunities for developing targeted interventions for different levels of vaccine hesitancy.
Reflectance confocal microscopy of facial neoplasms: Follicular involvement as a clue to diagnosis
Authors: Shahriari Neda , Grant‐Kels Jane M. , Rabinovitz Harold , Oliviero Margaret , Scope Alon 
Published: November 2022

AbstractBackgroundFacial skin is characterized by high density of follicles. Facial neoplasms may present overlapping clinical and dermoscopic findings. Our goal was to evaluate and compare, via reflectance confocal microscopy (RCM), follicular involvement in facial neoplasms.MethodsWe retrospectively searched our image database, between January 2008 and December 2020, for all facial lesions with (1) a standardized set of clinical, dermoscopic, and RCM images, and (2) a biopsy‐proven diagnosis of lentigo maligna/lentigo maligna melanoma (LM/LMM, n = 39), basal cell carcinoma (BCC, n = 51), squamous cell carcinoma in situ (SCCIS, n = 5), actinic keratosis (AK, n = 11), and lichen‐planus‐like keratosis (LPLK, n = 18). Two readers jointly evaluated the RCM images for a set of predefined features of follicular involvement.ResultsDiffuse obliteration of follicles was frequent in BCC (88%), while follicular infiltration by refractile dendritic cells and/or by bright round nucleated cells was common in melanoma (90% and 44%, respectively). Extension of atypical keratinocytes down follicles was more prominent among SCCIS than AK (80% vs. 45%, p = 0.01). In most LPLK (89%), there was follicular sparing.ConclusionsEvaluation of RCM criteria centering on the follicles can be useful in the differential diagnosis between common facial neoplasms.
Utility of transesophageal echocardiogram surveillance after watchman device placement
Authors: Wu Stephanie , Minhas Harjit , Shiota Takahiro , Siegel Robert J. , Rader Florian 
Published: November 2022

AbstractBackgroundIn atrial fibrillation patients undergoing left atrial appendage occlusion with a Watchman device, surveillance imaging with a transesophageal echocardiogram (TEE) is typically performed at 45 days and 1 year to evaluate for device‐related thrombus (DRT) and peri‐device leak (PDL) before the cessation of oral anticoagulation. The incidence of these complications is relatively low, and the ideal timing and duration of surveillance is unknown. We sought to evaluate the incidence of DRT and PDL after Watchman placement at 45 days and 1 year to determine the necessity of surveillance TEEs.MethodsWe retrospectively analyzed 361 patients who received a Watchman device between January 2016 and January 2020. Baseline clinical and echocardiographic data, post‐procedure antithrombotic therapy, and surveillance echocardiographic data were collected from the NCDR LAAO Registry. Nested backward variable elimination regression was performed to derive independent predictors of the composite outcome of DRT and PDL.ResultsA total of 286 patients who had post‐procedure TEEs were included in the analysis. At 45 days, 9 patients had DRT (3.2%) and 44 patients had PDL (15.0%). At 1 year, 5 patients had DRT (5.6%) and 8 patients had PDL (8.9%). All DRT at 45 days was treated with continued anticoagulation while no change in protocol occurred with PDL. All DRT at 1 year occurred in new patients without prior thrombus. A history of prior transient ischemic attack (TIA) and thromboembolism was significantly associated with DRT or PDL at 1 year.ConclusionsWe identified several patients with device‐related complications at 45 days and 1 year despite appropriate device sizing and adequate use of antithrombotic therapy. The incidence of DRT increased from 45 days to 1 year and occurred in patients without prior thrombus. These findings highlight the importance of surveillance imaging and suggest the potential need for extended surveillance in select patients.
Real‐world utility of early measurable residual disease assessments by multi‐parametric flow cytometry in adult patients with B‐lymphoblastic leukemia receiving Hyper‐CVAD induction chemotherapy
Authors: Nedumannil Rithin , Ritchie David , Bajel Ashish , Ng Ashley P. , Harrison Simon J. , Westerman David 
Published: November 2022

AbstractMulti‐parametric flow cytometry (MFC) has a well‐established role in measurable residual disease (MRD) monitoring in patients with B‐lymphoblastic leukemia (B‐ALL). However, the optimal time‐point (TP) for early MRD testing and associated prognostic impact remain undefined in adult B‐ALL patients receiving Hyper‐CVAD induction chemotherapy. To evaluate the utility of MRD analysis after one cycle (TP1) in comparison to MRD analysis after two cycles (TP2) of induction treatment with Hyper‐CVAD chemotherapy, we studied 49 adult B‐ALL patients over a 10‐year period (2010–2020) who had available bone marrow samples for morphological and MFC MRD assessments at the two separate TPs. Median times to TP1 and TP2 relative to start of treatment were 21 and 45 days, respectively. When censored at transplant, achievement of MRD negativity at TP1 was not associated with a statistically significant improvement in either event‐free survival (EFS) (p = .426) or overall survival (OS) (p = .335) when compared to patients with MRD positivity. In contrast, achieving MRD negativity at TP2 was associated with a statistically significant improvement in both EFS (p = ·005) and OS (p = .047) over patients who remained MRD positive. Multivariate analysis demonstrated that KMT2A‐rearrangement and MRD positivity at TP2 were the only significant predictors of outcome, correlating with worse EFS and OS. Therefore, in the absence of residual morphologic disease, MRD analysis after one cycle of Hyper‐CVAD induction chemotherapy did not provide additional benefit with regard to risk stratification or correlation with survival outcomes when compared to MRD testing after two cycles of Hyper‐CVAD in adult B‐ALL patients.
Farming with forages can reconnect crop and livestock operations to enhance circularity and foster ecosystem services
Authors: Franzluebbers Alan J. , Martin Guillaume 
Published: November 2022

AbstractAgriculture has undergone dramatic technological and cultural changes over the past century. Many would argue that the changes have been unquestionably positive with huge gains in productivity, reduced labour requirements, and alleviation of food insecurity for most people. However, the adoption of increasingly specialized and separated crop and livestock enterprises has also had widespread negative consequences resulting in (a) decline in biodiversity, (b) degradation of groundwater and surface waters with agrochemical pollutants, (c) poor soil health with monoculture crop production and frequent soil disturbance, (d) intensive greenhouse gas emissions from both specialized cropping systems relying on external inputs and concentrated animal feeding operations that accumulate wastes, and (e) general lack of ecological integrity among components of these specialized systems. Diversified agricultural systems using annual and perennial forages offer opportunities to elevate ecological synergies when crop and livestock operations are integrated. Integrated crop‐livestock systems can internalize nutrient cycling, provide cultural control of weeds, insects and diseases, and share resources in a circular‐based agroecosystem. Cover crops could be transitioned into nutritious annual forages for livestock grazing on currently specialized crop production farms with appropriate local incentives. Perennial forages in ley farming or in pasture‐crop rotations have historical relevance and are a proven practice for conserving nutrients, improving soil health and enhancing biodiversity. Redesigning contemporary agriculture with mixed‐use farming techniques could greatly reduce soil erosion, improve water quality, and invigorate soil health. We suggest that incorporating different types of forages across a diverse landscape can enhance agricultural sustainability and ecological integrity.