bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors of Pancreatic Cancer in Patients With Type 2 Diabetes Mellitus: The Hong Kong Diabetes Study
Authors: Chan Raymond Ngai Chiu , Lee Teddy Tai Loy , Chou Oscar Hou In , So Jenny , Chung Cheuk To , Dee Edward Christopher , Ng Kenrick , Tang Pias , Roever Leonardo , Liu Tong , Wong Wing Tak , Tse Gary , Lee Sharen 
Published: September 2022

Abstract

Context
Diabetes mellitus (DM) is associated with the development of pancreatic cancer (PaC), but few large-scale studies have examined its predictive risk factors.

Objective
The present study aims to examine the predictors for PaC in patients with type 2 diabetes mellitus (T2DM) in a territory-wide, retrospective cohort study.

Methods
This was a territory-wide, retrospective cohort study of patients with T2DM mellitus older than 40 years with no prior history of PaC. Baseline demographics, use of antidiabetic medications, comorbidities, and biochemical parameters were extracted. Cox regression was used to calculate hazard ratios (HR) with 95% CI. Subgroup analyses based on chronic kidney disease (CKD) stages were performed.

Results
This study consisted of 273 738 patients (age = 65.4 ± 12.7 years, male = 48.2%, follow-up duration = 3547 ± 1207 days, disease duration = 4.8 ± 2.3 years), of whom 1148 developed PaC. The number of antidiabetic medications prescribed (HR: 1.20; 95% CI, 1.01-1.42; P = .040), diabetic microvascular complications (HR: 1.91; 95% CI, 1.30-2.81; P &lt; .001), chronic kidney disease (HR: 1.81; 95% CI, 1.25-2.64; P = .002), use of acarbose (HR: 2.24; 95% CI, 1.35-3.74; P = .002), and use of glucagon-like peptide-1 receptor agonist (HR: 4.00; 95% CI: 1.28-12.53, P = .017) were associated with PaC development on multivariable Cox regression adjusting for the duration of DM, mean glycated hemoglobin A1c, and history of pancreatic diseases. Stage 3A CKD or below was associated with PaC but not stage 3B or beyond.

Conclusion
Diabetic microvascular complications, especially stage 1, 2, and 3A CKD, were associated with PaCs.
Evaluation of ellagic acid and gallic acid as efflux pump inhibitors in strains of Staphylococcus aureus
Authors: Macêdo Nair Silva , Barbosa Cristina Rodrigues dos Santos , Bezerra Antonio Henrique , Silveira Zildene de Sousa , da Silva Larissa , Coutinho Henrique Douglas Melo , Dashti Saeid , Kim Bonglee , da Cunha Francisco Assis Bezerra , da Silva Marcia Vanusa 
Published: September 2022

ABSTRACT
The Gram-positive bacterium Staphylococcus aureus is responsible for a number of infections and has been described to exhibit resistance to antibacterial drugs through different resistance mechanisms. Among these, active efflux has been shown to be one of the main mechanisms of bacterial resistance associated with S. aureus. In this sense, the aim of the present study was to evaluate the ability of ellagic acid and gallic acid to reverse resistance by inhibiting the efflux pumps present in S. aureus strains IS-58 and K2068, which express the TetK and MepA flux pumps, respectively. In addition, the toxicity of both compounds was verified in Drosophila melanogaster. Broth microdilution assays were performed to obtain the minimum inhibitory concentration (MIC) values of ellagic acid and gallic acid, whereas efflux pump inhibition was tested using a subinhibitory concentration of standard efflux pump inhibitors, gallic acid and ellagic acid (MIC/8), where the ability of these compounds to decrease the MIC of ethidium bromide (EtBr) and antibiotics was verified. Toxicity was evaluated by mortality and negative geotaxis assays in D. melanogaster. Ellagic acid and gallic acid showed no direct antibacterial activity on S. aureus strains carrying the efflux pumps TetK and MepA. However, when we looked at the results for the TetK pump, we saw that when the two acids were associated with the antibiotic tetracycline, a potentiation of the antibacterial effect occurred; this behavior was also observed for the antibiotic ciprofloxacin in the MepA strain. For the efflux pump inhibition results, only the compound gallic acid showed potentiating effect on antibacterial activity when associated with the substrate EtBr for the IS-58 strain carrying the TetK efflux pump. Ellagic acid and gallic acid showed no toxicity on the model arthropod D. melanogaster. These results indicate the possible use of gallic acid as an adjuvant in antibiotic therapy against multidrug-resistant bacteria.
Fertility-Sparing Treatment for Early-Stage Cervical Cancer ≥ 2 cm: A Problem with a Thousand Nuances—A Systematic Review of Oncological Outcomes
Authors: Ronsini Carlo , Solazzo Maria Cristina , Bizzarri Nicolò , Ambrosio Domenico , La Verde Marco , Torella Marco , Carotenuto Raffaela Maria , Cobellis Luigi , Colacurci Nicola , De Franciscis Pasquale 
Published: September 2022

Abstract
Background
Fertility-sparing treatments (FSTs) have played a crucial role in the management of early-stage cervical cancer (ECC). The guidelines have recognized various approaches, depending on the tumor stage and other risk factors such as histotype and lymphovascular positivity. Much more debate has centered around the boundary within which these treatments should be considered. Indeed, these are methods to be reserved for ECC, but tumor size may represent the most significant limitation. In particular, there is no consensus on the strategy to be adopted in the case of ECC ≥ 2 cm. Therefore, this systematic review was to collect the literature evidence regarding the management of these patients.

Methods
Following the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we systematically searched the Pubmed and Scopus databases was conducted in April 2022, from the date of the first publication. We made no limitation on the country. We included all studies containing data on disease-free survival, overall survival, recurrence rate (RR), or complete response rate (CRR) to chemotherapy.

Results
Twenty-six studies fulfilled the inclusion criteria, and 691 patients were analyzed regarding FST. Surgery-based FST showed an RR of between 0 and 42.9%, which drops to 12.9% after excluding the vaginal or minimally invasive approaches. Furthermore, papers regarding FST based on the neoadjuvant chemotherapy (NACT) approach showed a CRR of between 21.4 and 84.5%, and an RR of between 0 and 22.2%

Conclusion
This paper focused on the significant heterogeneity present in the clinical management of FST of ECC ≥ 2 cm. Nevertheless, from an oncological point of view, approaches limited to the minimally invasive or vaginal techniques showed the highest RR. Vice versa, the lack of standardization of NACT schemes and the wealth of confounders to be attributed to the histological features of the tumor make it difficult, if not impossible, to set a standard of treatment.
Modified gun-sight transjugular intrahepatic portosystemic shunt technique
Authors: Lukies Matthew , Moriarty Heather , Phan Tuan 
Published: September 2022

Objectives: Conventional transjugular intrahepatic portosystemic shunt (TIPS) stent insertion is an established procedure with high rates of technical success. However, alternative techniques may increase success rates in the setting of challenging anatomy or limited resources. Originally described as a salvage porto-caval approach, we present a modified gun-sight porto-hepatic TIPS technique. Methods: A retrospective review was performed identifying patients who underwent modified gun-sight TIPS over a 1-year period. Six procedures were identified, with snares opened in the target hepatic and portal veins, fluoroscopic percutaneous transhepatic puncture through the snares, and wire pulled through-and-through to establish a parenchymal tract. Five modified gun-sight procedures were primary, and one was salvage. Results: All modified gun-sight TIPS procedures were technically successful with a single needle pass, with patency and appropriate haemodynamic flow at 2 weeks. Advantages of the technique include fluoroscopic-guided transhepatic puncture utilising typically on-shelf low-cost equipment, without requiring a dedicated TIPS set or endovascular ultrasound. Disadvantages include liver capsular puncture. Conclusions: The modified gun-sight TIPS technique is an alternative approach utilising typically on-shelf and low-cost equipment for a targeted fluoroscopic-guided parenchymal puncture. Advances in knowledge: The presented technique is an initial description of a novel alternative TIPS technique, which may be useful to consider in challenging cases.
A hazai feminizmus története iránti érdeklődés megújulása
Authors: Acsády Judit 
Published: September 2022

Magyarországon a rendszerváltást megelőzően a feminizmus kutatása szinte teljesen kimaradt a történelem- illetve a társadalomkutatásokból. A nőmozgalmi előzményekre ugyan kitért néhány kötet, de ezek elsősorban a szavazati joggal kapcsolatos és a munkásmozgalmi vonatkozásokra koncentráltak. A rendszerváltás éveiben – azzal párhuzamosan, hogy a szervezkedési szabadság törvénybe léptetésével és az eszmék szabad áramlásával kialakul egy új feminista hullám, szervezetekkel és mozgalmi akciókkal (Kelet-Európa szerte) – megindul az érdeklődés a feminista múlt iránt is. Ezeknek az új irányzatoknak az identitásához tartozott a korábbi mozgalmak feltárása is (hasonlóan a nyugati mozgalmakhoz). A jelen gondolatébresztő írás célja, hogy a felvesse az önreflexió kérdéseit: mi motiválja az új tudományos érdeklődést? Mi lehet a feminizmus történet feltárásának célja, jelentősége és tétje Kelet-Európában? Megjelennek-e szakmai együttműködések a téma kutatói között?
HUBUNGAN SELF MONITORING DENGAN PERILAKU KONSUMTIF PEMBELIAN GADGET PADA SISWA SMA ISLAM AL AZHAR 14 SEMARANG
Authors: Santoso Alif Kumara , Prasetyo Anggun Resdasari 
Published: September 2022

Self Monitoring adalah kecenderungan untuk mengatur tingkah laku berdasarkan petunjuk eksternal, mengikuti bagaimana orang lain bereaksi (self-monitoring tinggi) atau berdasarkan petunjuk internal seperti keyakinan seseorang dan sikapnya (self-monitoring rendah). Perilaku konsumtif merupakan kegiatan menggunakan barang atau jasa untuk memperoleh kepuasan sebesar-besarnya. Kepuasan ini dapat diraih dari manfaat atau daya guna dari barang atau jasa. Penelitian ini bertujuan untuk mengkaji hubungan antara self monitoring dengan perilaku konsumtif pada siswa SMA Islam Al Azhar 14 Semarang. Populasi dalam penelitian ini adalah siswa kelas 10 dan 11 SMA Islam Al Azhar 14 Semarang dengan jumlah sampel penelitian berjumlah 129 siswa. Teknik sampling yang digunakan adalah teknik total sampling. Metode pengumpulan data menggunakan dua buah skala psikologi, yaitu Skala Perilaku Konsumtif dan Skala Self Monitoring. Metode analisis data yang digunakan adalah analisis regresi linier sederhana. Hasil analisis data menunjukkan terdapat hubungan positif signifikan antara self monitoring dengan perilaku konsumtif (rxy= 0,405 ; p< 0,001). Semakin tinggi self monitoring maka semakin tinggi perilaku konsumtif. Begitu juga sebaliknya semakin rendah self monitoring maka semakin rendah perilaku konsumtif. Perilaku konsumtif dapat dijelaskan oleh self monitoring sebesar 16,4% dan sisa 86,4% dipengaruhi oleh faktor-faktor yang tidak diukur di dalam penelitian.
ANALISIS PRAKTIK PEMELIHARAAN GIGI DAN MULUT BALITA SEBAGAI PENCEGAHAN EARLY CHILDHOOD CARIES OLEH ORANGTUA/WALI DI PROVINSI JAWA TENGAH
Authors: Zuqriefa Arida Bitanajsha , Widjanarko Bagoes , Indraswari Ratih 
Published: September 2022

Early Childhood Caries is a serious dental and oral health disease that occurs when child is at preschool stage, where at this time, children expepriencing growth of the primary teeth, that are still susceptible. Untreated dental caries problem on children, can cause several problems, such as being underweight, poor performance at school, school absent, and also poor quality of life. Based on the 2018 RISKESDAS, 42,11% children aged 3-4 years in Central Java is having oral health problem, but only 3.95% that receive medical care from health professional. Good oral hygine is important for oral health, and also overall health. The aim of this study is to see factors that related to oral hygiene practice for children under five years old by parents or guardians, as an effort to prevent Early Childhood Caries (ECC) in Central Java.This study is a quantitative research, with cross sectional approach. The number of responden in this this study were 98, that determined uising purposive sampling technique. The study results showed that 51% of parents/guardians had a poor practices at maintaining children’s oral health. Factors that influence their practice were parent’s attitude (p=0,005), parents knowledge (p=0,000), and also the accessibility of oral health information (p=0,009).
ANALISIS MANAJEMEN RISIKO K3 SELAMA PANDEMI COVID-19 DI RUMAH SAKIT JIWA PROF. DR. SOEROJO MAGELANG
Authors: Miftachul Adna Ana Nur , Lestantyo Daru , Wahyuni Ida 
Published: September 2022

Rumah sakit menjadi salah satu tempat yang wajib menerapkan Sistem Manajemen Keselamatan dan Kesehatan Kerja (SMK3). Manajemen rumah sakit harus menyelenggarakan upaya manajemen risiko keselamatan dan kesehatan kerja (K3) dalam menghadapi pandemi COVID-19 saat ini. Oleh karena itu, Penelitian ini bertujuan untuk Menganalisis kesiapan RSJ Prof. Dr. Soerojo Magelang dalam menghadapi pandemi COVID-19. Penelitian ini merupakan jenis penelitian kualitatif dengan desain observasional analitik yang menggunakan -pendekatan wawancara mendalam. Metode pengambilan data dilakukan melalui wawancara mendalam dengan 4 informan utama dan 2 orang informan triagulasi. Hasil penelitian menunjukkan bahwa RSJ Prof. Dr. Soerojo Magelang telah melakukan penanggulangan pandemi Covid-19 seperti terdapat kebijakan terkait dengan pencegahan dan pengendalian COVID-19 berdasarkan keputusan direktur, dan adanya program kerja yang bertujuan untuk mengurangi risiko penyebaran COVID-19 kepada petugas, pasien non COVID-19, keluarga atau masyarakat, dan lingkungan rumah sakit. Namun dalam pelaksanaannya masih terdapat inkosistensi seperti program PPI belum diketahui oleh semua karyawan dan terdapat beberapa sarana yang masih berpotensi menjadi sarana penularan virus.
PEMBERDAYAAN PEREMPUAN MELALUI PELATIHAN PENGOLAHAN MAKANAN UNTUK MENGATASI STUNTING BALITA DI DAERAH PERDESAAN
Authors: Siswati Tri , Afiati Sabrina Nur , Alit Gunawan I Made 
Published: September 2022

Stunting is global malnutrition problem. The adequate consumption is essential determinants of children malnourish. Women's empowerment is an important strategy to improve nutritional status of underfive children. This research was to determine the effectiveness of empowering mothers to increase knowledge, attitude, and skill of providing healthy food. This was an experimental study with pre-post test design. The located was in rural locus stunting areas in Kulon Progo on 2019. Women empowerment was provided by three days training about stunting and providing healthy food for stunting children. The dependent variable were knowledge, attitude and practise were observed by a structure questionnaire pre and post-intervention and check list. Subjects were 30 mothers who consenting to be participant. Data pre-post test of knowledge and attitude were analyzed by Wilcoxon test. Result showed that knowledge and attitudes increased by 9.7 and 14.3 point respectively and statistically significant. While after intervention as many as 80% mothers has excellent skills on providing healthy food for stunting children. In general this research increases knowledge and attitudes of mother’s, also edvancing skill on providing healthy food for improving nutritional children.
Gambaran Pelaksanaan Rumah Pemotongan Hewan Babi (Studi Kasus di Rumah Pemotongan Hewan Kota Semarang)
Authors: Rambu Lawu Michelia , Yuliawati Sri , Dian Saraswati Lintang 
Published: September 2022

Rumah Pemotongan Hewan adalah bangunan yang memenuhi persyaratan teknis dan hygiene untuk memotong hewan bagi masyarakat sehingga dapat menjadi titik kritis pertama penentuan keamanan produk daging yang dijual. Kementerian pertanian mengungkapkan bahwa RPH yang telah memenuhi standar penyembelihan sesuai dengan standar operasional prosedur hanya berkisar 41,42% dari jumlah RPH yang tersebar di seluruh Indonesia tahun 2010. Penelitian ini menggunakan metode survei dengan pendekatan cross sectional dimana variabel penelitian ini merupakan standar operasional prosedur rumah pemotongan hewan babi dengan tujuan untuk memberikan gambaran pelaksanaan operasional RPH Babi Kota Semarang yang sesuai dengan standar operasional prosedur yang telah dipersyaratkan. Dan dari penelitian ini ditemukan ada beberapa persyaratan berdasarkan SNI No 01-6159-1999 dan berdasarkan peraturan menteri pertanian No 13/permentan/OT.140/2000, Standar operasional prosedur berdasarkan peraturan daerah (Keputusan Dewan No 48 tahun 2000) serta berdasarkan standar operasional prosedur RPH babi yang tidak terpenuhi dan tidak dilaksanakan dimana salah satunya adalah tidak dilakukannya pemeriksaan antemortem dan postmortem sehingga tidak memperoleh nomor kontrol veteriner dari dokter hewan RPH. Dalam hal ini pengawasan yang rutin dan berkala dari dinas peternakan merupakan hal penting yang harus dilakukan untuk memperbaiki pelaksanaan standar operasional prosedur di RPH babi Kota Semarang ini
Hubungan Praktek Pengaturan Diet Dengan Perilaku Emosional Pada Penyandang Autism Spectrum Disorder (ASD) Usia 3-7 Tahun Di Kota Depok
Authors: Mukhfi - , Nugraheni S.A. , Kartini Apoina 
Published: September 2022

Autism spectrum disorder (ASD) is a pervasive developmental disorder characterized by the development that appears before the age of 3 years , characteristic function abnormalities in three areas, social interaction, communication, limited and repetitive behavior. UNESCO in 2011 , there were 35 million people with ASD in the entire world, 6 of 1000 people in the world have been suspect ASD. While in Indonesia, the ratio of 8 out of every 1000 people. Child asd have allergic to nutrient substance that causes disruption brain functions consequently emotion. This study aims to analyze relationship the practice of diet between with the emotional ASD children aged 3-7 years in Depok. This research uses a cross-sectional study with survey method. The population in this study is child with ASD was therapy in 5 clinic therapy for children with special needs (Anak Mandiri, Talenta Optima, Lentera Insan, Kriebel, Rumah Autis Depok). using the total sampling method 35 children was respondents. using Chi-square for analysis data with 5% significance level. The result showed children with ASD has emotional stable more on child with diet (70,6 %) than child is not on a diet (16 %). The statistics chi-square obtained value p-value 0,001. The concluded that diet practices haved a relationship with emotional in ASD children ages 3-7 years in Depok city
Preparation of CoFe2O4/SiO2/Ag Magnetic Composite as Photocatalyst for Congo Red Dye and Antibacterial Potential
Authors: Salni Salni , Said Muhammad , Eliza Eliza , Gayatri Anggun Dita Dyah , Hariani Poedji Loekitowati 
Published: September 2022

This research reports the synthesized CoFe2O4/SiO2/Ag magnetic composite used as a photocatalyst to degrade Congo red dye and antibacterial agent against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The catalysts were characterized using XRD, SEM-EDS, VSM, UV-DRS, and pHpzc. The effects of photocatalyst dose (0.25, 0.5, 0.75, and 1.0 g/L), dye concentration (10, 20, 30, and 40 mg/L), and irradiation time (0–210 minutes) were all examined as photocatalytic degradation variables. The results showed that the CoFe2O4/SiO2/Ag composite was superparamagnetic with a saturation magnetization of 41.82 emu/g and had a band gap of 1.82 eV. The highest efficiency of decreasing the concentration of Congo red dye of 93.70% was obtained with an initial concentration of 10 mg/L, a catalyst dose of 0.5 g/L, and an irradiation time of 180 minutes. This study indicated that the composite had antibacterial properties against Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria with the same MIC value of 1.25%. These results indicated that the CoFe2O4/SiO2/Ag composite has significant potential for applications in wastewater treatment.
Macroalgae of the high-Arctic Severnaya Zemlya Archipelago
Authors: Mikhaylova Tatiana A. , Spiridonov Vassily A. , Gavrilo Maria V. , Ivanov Stepan D. 
Published: September 2022

Abstract
Most of the archipelagos of the Russian Arctic are still extremely poorly studied. New data have been obtained using SCUBA diving and on-shore sampling during the“Open Ocean: Arctic Archipelagos – 2019. Severnaya Zemlya” expedition, which provided a significant update to scarce information on the seaweeds of the Severnaya Zemlya Archipelago. The list of macroalgae of the archipelago includes 48 species to date, belonging to Chlorophyta (17 species), Rhodophyta (18), and Phaeophyceae (13). Twenty-eight species are recorded for the first time in the study area; three species are new for the entire Russian Arctic. The taxonomic status of some observed species is discussed. For the first time, a wide distribution of kelps is described in the sub-tidal zone in the high-Arctic areas of the Siberian shelf, which is severely affected by ice disturbance and glacial processes. The highest population densities of the kelp communities have been observed near the Krasnoflotskie Islands (the Kara Sea) and in the Akhmatov and Mikoyan bays (the Laptev Sea). Further studies of the flora and vegetation of both the Severnaya Zemlya Archipelago shelf and other Arctic archipelagos are required.
Omicron variant in COVID-19 current pandemic: a reason for apprehension
Authors: Kamble Prafull , Daulatabad Vandana , Patil Ramesh , John Nitin Ashok , John Jyoti 
Published: September 2022

Abstract
COVID-19 emerged in Wuhan, China, but was caused by the original coronavirus, severe acute respiratory syndrome associated coronavirus-2 (SARS-CoV2). In early 2020, there was a widespread breakout of cases well over world, resulting in an epidemic that rapidly escalated to become a pandemic. This abruptly shook the global healthcare system. The emergence of the alpha, beta, and delta SARS-CoV-2 were associated with new waves of infections, sometimes across the entire world but until this month i.e., between Nov-Dec, 2021, Delta variant reigned supreme until the emergence of a newer variant i.e., Omicron (B.1.1.529) of SARS-CoV-2. Delta had 13 mutations. Of these, nine are in the spike protein, the protrusion on the surface of the virus that helps it latch onto human cells. Specifically, two are in a molecular hook, called the “receptor-binding domain”. Omicron, a creation caused by monstrous mutations. At least 32 mutations are in the spike protein and 10 in the receptor-binding domain. was designated a COVID-19 variant of concern (VoC) by the World Health Organization (WHO) on 26th November 2021. Structurally, the omicron variant has shown too mutated at antibody binding sites which would leverage them for escaping the possible immune response by the body. We don’t yet know much about the other alterations and how they might affect the virus’s behavior. Omicron COVID-19 strain after identifying individuals with symptoms that were not the same as those seen in the Delta form. People with night sweats have also been reported. The new omicron variant has more mutations than the prevailing rampant delta virus. This makes the newer variant more transmissible, better able to evade itself from various vaccines readily available in the current scenario. These overall increases in the percentage changes in a single day cases of COVID-19 reported cases can be attributed to the beginning of third wave or can be speculated as newer surge of omicron variant cases. Yet another new variant has been detected in France with 46 mutations and 37 deletions in its genetic code, many affecting the spike protein. ‘B.1.640.2’ is the current nomenclature for this variation.