bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Path Toward Short-Term Probabilistic Flash Flood Prediction
Authors: Martinaitis Steven M. , Wilson Katie A. , Yussouf Nusrat , Gourley Jonathan J. , Vergara Humberto , Meyer Tiffany C. , Heinselman Pamela L. , Gerard Alan , Berry Kodi L. , Vergara Andres , Monroe Justin 
Published: September 2022

Abstract
There are ongoing efforts to move beyond the current paradigm of using deterministic products driven by observation-only data to make binary warning decisions. Recent works have focused on severe thunderstorm hazards, such as hail, lightning, and tornadoes. This study discusses one of the first steps toward having probabilistic information combined with convective-scale short-term precipitation forecasts available for the prediction and warning of flash flooding. Participants in the Hydrometeorology Testbed–MRMS Hydrology (HMT-Hydro) experiment evaluated several probabilistic-based hydrologic model output from the probabilistic Flooded Locations and Simulated Hydrographs (PRO-FLASH) system during experimental real-time warning operations. Evaluation of flash flood warning performance combined with product surveys highlighted how forecasters perceived biases within the probabilistic information and how the different probabilistic approaches influenced warnings that were verified versus those that were unverified. The incorporation of the Warn-on-Forecast System (WoFS) ensemble precipitation forecasts into the PRO-FLASH product generation provided an opportunity to evaluate the first coupling of subhourly convective-scale ensemble precipitation forecasts with probabilistic hydrologic modeling at the flash flood warning time scale through archived case simulations. The addition of WoFS precipitation forecasts resulted in an increase in warning lead time, including four events with ≥29 min of additional lead time but with increased probabilities of false alarms. Additional feedback from participants provided insights into the application of WoFS forecasts into warning decisions, including how flash flood expectations and confidence evolved for verified flash flood events and how forecast probabilistic products can positively influence the communications of the potential for flash flooding.
Using a Synoptic-Scale Mixing Diagnostic to Explain Global Precipitation Variability from Weekly to Interannual Time Scales
Authors: Perez Gabriel M. P. , Vidale Pier Luigi , Dacre Helen , García-Franco Jorge L. 
Published: September 2022

Abstract
Precipitation often happens along organized filaments or bands of moisture such as convergence zones. Recent regional studies have shown that these moisture filaments arise from synoptic-scale mixing features known as attracting Lagrangian coherent structures (LCSs). In this study, we present a climatology of synoptic-scale mixing and investigate its covariability with precipitation on temporal scales ranging from weekly to interannual. We characterize mixing with the finite-time Lyapunov exponent (FTLE), a measure of parcel deformation, in ERA5 data between 1980 and 2009. Attracting LCSs are identified as ridges of the FTLE. At the interannual time scale, we compare El Niño and La Niña events and find that composites of precipitation and mixing anomalies share similar spatial patterns. We also compare summer and winter seasons and find that composites of seasonal-mean precipitation and mixing anomalies present similar characteristics, with precipitation being particularly intense (weak) where mixing is strong (weak). In particular, these patterns closely match the typical signatures of the intertropical convergence zone (ITCZ) and monsoon systems and the migrations of extratropical cyclone tracks. At the subseasonal scale, we employ daily composites to investigate the influence of the Madden–Julian oscillation and the North Atlantic Oscillation on the mixing regimes of the Atlantic and east Pacific; our results indicate that these oscillations control the synoptic-scale horizontal mixing and the occurrence of LCSs as to suppress or enhance precipitating systems like the ITCZ and the South Atlantic convergence zone. The results presented in this first climatology of synoptic-scale mixing and LCSs indicate that these are powerful diagnostics to identify circulation mechanisms underlying precipitation variability.
Evaluations of Funerals and Health Trajectories in the Second Year After Bereavement—The Ongoing Japan National Survey
Authors: Becker Carl B. , Taniyama Yozo , Sasaki Noriko , Kondo-Arita Megumi , Yamada Shinya , Yamamoto Kayoko 
Published: September 2022

Our nationwide postal survey analyzing 190 responses from Japanese bereaved who had responded a year earlier found that funeral dissatisfaction rose during the second year after the funeral. Controverting previous research advocating participation in funeral planning, elderly bereaved spouses forced to decide about and/or pay for the funeral showed elevated grief as much as 2 years later. While not reaching levels diagnosed as prolonged, traumatic, or complicated grief, nevertheless one out of three of our bereaved sample showed continuing daily symptoms of grief from 14 to 24 months after their bereavement, with continued or increasing use of tranquillizers or antidepressants. The medical and pharmaceutical costs incurred by mourners more than a year after bereavement warrant further research into what factors improve or exacerbate the health of grieving bereaved, not limited to a single year after the bereavement.
Increased Endotoxin Activity in COVID-19 Patients Admitted to the Intensive Care Unit
Authors: Dela Cruz Philip T.H. , Davison Danielle , Yamane David P. , Chu Everett , Seneff Michael 
Published: September 2022

Objective Endotoxin is a component of Gram-negative bacteria and can be measured in blood using the endotoxin activity assay (EAA). Endotoxin exposure initiates an inflammatory cascade that may contribute to organ dysfunction. Endotoxemia has been reported in previous viral pandemics and we investigated the extent of endotoxemia and its relationship to outcomes in critically ill patients with COVID-19. Materials and Methods We conducted a Prospective Cohort Study of 96 critically-ill COVID-19 patients admitted to the George Washington University Hospital ICU from 25 Mar-6 Jun 2020. EAA and inflammatory markers (ferritin, d dimer, IL-6, CRP) were measured on ICU admission and at the discretion of the clinical team. Clinical outcomes (mortality, LOS, need for renal replacement therapy (RRT), intubation) were measured. Statistical analysis was conducted using descriptive statistics and effect estimates with 95% confidence intervals. Comparisons were made using chi-square tests for categorical variables, and T-tests for continuous variables. Results A majority of patients (68.8%) had high EAA [≥ 0.60], levels seen in septic shock. Only 3 patients had positive bacterial cultures. EAA levels did not correlate with mortality, higher levels were associated with greater organ failure (cardiovascular, renal) and longer ICU LOS. Among 14 patients receiving RRT for severe AKI, one had EAA < 0.6 (p = 0.043). EAA levels did not directly correlate with other inflammatory markers. Conclusions High levels of endotoxin activity were found in a majority of critically-ill COVID-19 patients admitted to the ICU and were associated with greater risk for cardiovascular and renal failure. Further investigation is needed to determine if endotoxin reducing strategies are useful in treating severe COVID-19 infection.
Systematic review and meta-analysis comparing the autogenous vein bypass versus a prosthetic graft for above-the-knee femoropopliteal bypass surgery in patients with intermittent claudication
Authors: Vossen RJ , Fokkema TM , Vahl AC , Balm R 
Published: September 2022

Objectives According to guidelines, the autogenous saphenous vein (ASV) is the preferred conduit for femoropopliteal bypass surgery in all patients with peripheral artery disease. However, in contrast to patients with critical limb ischemia (CLI), patients with intermittent claudication (IC) only, tend to have milder disease, and thus a prosthetic graft may be as good as a vein conduit. The objective of this study was to compare patency rates of the ASV and a prosthetic graft in femoropopliteal bypass surgery in patients with IC. Methods A systematic literature search was performed in the PubMed, Embase, and Cochrane databases to identify randomized controlled trials comparing prosthetic graft versus ASV in patients with IC. Articles with a mixed IC and CLI study population were included if more than 50% of the study cohort was treated for IC. Primary analysis was performed on IC patients only. Secondary analysis was performed on the mixed group. The primary endpoint was short- and long-term patency and secondary endpoints were complications, limb salvage, and mortality. Results In total, six studies with 524 patients were included. Only two studies reported solely on patients with IC. All these patients underwent above-the-knee bypasses and average patency rates at one and 5 years were 88% and 76% vs 81% and 68% in the ASV and the PTFE groups, respectively. One and five-year patency was not statistically different between the groups (OR 5.21; 95% CI 0.60–45.36 and OR 2.10; 95% CI 0.88–5.01). In a mixed population of patients with IC and CLI (84% IC patients), 1 year patency was comparable (OR 1.40; 95% CI 0.87–2.25). However, after a follow-up of over 3 years, this mixed group had significantly higher patency rates in favour of the ASV (OR 2.06; 95 % CI 1.30–3.26). Complication and amputation rates were comparable in both groups. Conclusions Limited data are available for patients receiving above-the-knee femoropopliteal bypass for intermittent claudication. The ASV remains the conduit of choice for femoropopliteal bypass surgery. However, the prosthetic conduit seems a feasible alternative for patients with intermittent claudication in whom the ASV is not present or unsuitable.
Validity of serum and urinary hepcidin as biomarkers for late-onset sepsis in premature infants
Authors: Sherbiny Hanan Sakr , Mostafa Hanaa Abdel-el Fattah , Sherief Laila M. , Kamal Naglaa M. , El-Shal Amal Saeed , Abdel-el Halm Mahmoud Mohamed , Khan Hekmat Yaqoub , Ali Al Shaymaa Ahmed 
Published: September 2022

Background: Sepsis remains one of the leading causes of neonatal morbidity and mortality, particularly among premature infants. Blood culture is the ‘gold standard’ for the diagnosis of neonatal sepsis but is associated with several pitfalls. Aim of the work: We aim to evaluate the validity of measuring serum (S.Hep) and urinary hepcidin (U.Hep) concentrations as diagnostic biomarkers for late-onset sepsis (LOS) in preterm infants. Patients and Methods: The current case-control study included 73 cases of clinically and laboratory confirmed late-onset sepsis as the ‘case group’ and 50 nonseptic premature infants of comparable age and sex as the ‘control group’. S.Hep and U.Hep concentrations were evaluated at enrollment (acute sample) and after 1 week of treatment (convalescent sample). Results: Patients had a statistically significant higher concentration of both S.Hep and U.Hep as compared with nonseptic controls ( p = 0.0001). Similarly, a significant reduction of both S.Hep and U.Hep was detected after 1 week of treatment ( p = 0.001). A cut-off value of ⩾ 94.8 ng/ml of S.Hep and ⩾ 264 ng/mg of U.Hep/urinary creatinine showed high sensitivity, specificity, and positive predictive value in the diagnosis of neonatal LOS. Conclusions: Both S.Hep and U.Hep can function as promising accurate and rapid surrogate tests for the diagnosis of LOS. U.Hep measurement has the advantage of being noninvasive, with no hazards of phlebotomy, and is less variable throughout the day.
Development of a deprescribing manual for frail older people for use in the COFRAIL study and in primary care
Authors: Mann Nina-Kristin , Schmiedl Sven , Mortsiefer Achim , Bencheva Veronika , Löscher Susanne , Ritzke Manuela , Drewelow Eva , Feldmeier Gregor , Santos Sara , Wilm Stefan , Thürmann Petra A. ,   for the COFRAIL study group
Published: September 2022

Introduction: Many older adults are affected by multimorbidity and subsequent polypharmacy which is associated with adverse outcomes. This is especially relevant for frail older patients. Polypharmacy may be reduced via deprescribing. As part of the complex intervention in the COFRAIL study, we developed a deprescribing manual to be used by general practitioners (GPs) in family conferences, in which GPs, patients and caregivers jointly discuss treatments. Methods: We selected indications with a high prevalence in older adults in primary care (e.g. diabetes mellitus, hypertension) and conducted a literature search to identify deprescribing criteria for these indications. We additionally reviewed clinical practice guidelines. Based on the extracted information, we created a deprescribing manual which was then piloted in an expert workshop and in family conferences with volunteer patients according to the inclusion and exclusion criteria of the study protocol. Results: Initially, 13 indications/topics were selected. The literature search identified deprescribing guides, reviews and clinical trials as well as lists of potentially inappropriate medication and systematic reviews on the risk and benefits of specific drugs and drug classes in older patients. After piloting and revisions, the deprescribing manual now covers 11 indications/topics. In each chapter, patient- and medication-related deprescribing criteria, monitoring and communication strategies, and information about concerns related to the use of specific drugs in older patients are provided. Discussion: We found varying deprescribing strategies in the literature, which we consolidated in our deprescribing manual. Whether this approach leads to successful deprescribing in family conferences is being investigated in the cluster-randomised controlled COFRAIL study. Plain Language Summary Development of a manual to help doctors to identify which medications can be withdrawn Many older adults suffer from chronic diseases and take multiple medications concurrently. This can lead to side effects and other undesired events. We developed a manual to help doctors identify which medications can be withdrawn, so that they can discuss this with their patients. This manual was used in the COFRAIL study where doctors, patients and caregivers met in family conferences to discuss their preferences and decide together how future treatments should be handled. The manual contains information on common medications, symptoms and diseases in older patients such as diabetes and high blood pressure. Before the manual was used in the study, it was tested by volunteer patients and their doctors and caregivers to make sure that it is user-friendly.
Effectiveness of antenatal intermittent preventive treatment for malaria with sulphadoxine-pyrimethamine on peripartum outcomes
Authors: Godwin Isaac Okezie , Ekejindu Ifeoma Mercy , Eleje George Uchenna , Ezeagwuna Dorothy Amauche , Okafor Chigozie Geoffrey , Onwuegbuna Arinze Anthony , Umeononihu Osita Samuel , Godwin Prisca Obiageli , Ogelle Onyecherelam Monday , Ikechebelu Joseph Ifeanyichukwu 
Published: September 2022

Background: Following the World Health Organization (WHO) recommendations for 4-weekly antenatal intermittent preventive treatment of malaria in pregnancy using sulphadoxine-pyrimethamine (IPTp-SP), there is a need to evaluate the drug performance in order to determine their effectiveness as tools in malaria control policy. Objectives: To determine prevalence of cord blood malaria, compliance gap and adverse pregnancy outcomes (anaemia, preterm delivery, spontaneous abortion, intra-uterine foetal death and low birth weight) among antenatal IPTp-SP users compared with non-users. Methods: A cross-sectional analytical study was conducted among consenting 390 participants who were administered a questionnaire, and paired blood samples were collected from the venous blood of participants and neonatal cord immediately after delivery. The participants were categorised as IPTp-SP users and non-users. Adverse pregnancy outcomes were assessed. Neonatal birth weights were also measured within 1 h after delivery. Malaria parasitaemia and anaemia were analysed using standard parasitological and haematological methods of examination. Data were analysed using SPSS version 25 for Windows and p-value of < 0.05 considered significant. Results: Of 390 women, 336 (86.2%) were IPTp-SP users, while 54 (13.8%) were non-users. The compliance gap was 13.8%. Malaria parasitemia in pregnant women (21.7% versus 53.7%; p < 0.001) and their babies (12.2% versus 25.4%; p = 0.002) were observed for IPTp-SP users and non-users, respectively. The prevalence of maternal anaemia was 27(8.0%) in IPTp-SP users and 5 (9.3%) in non-users ( p = 0.789). Mean parasite density was reduced in IPTp-SP users than in non-users ( p < 0.001). Correlation of birth weight according to their sex showed a weak correlation [correlation coefficient ( r) = 0.027; p = 0.736]. Pregnant women with preterm delivery, spontaneous abortion, intra-uterine foetal death, and low birth weight were significantly lower ( p < 0.001, for all) in IPTp-SP users compared with non-users. Conclusion: Although the compliance gap was low, IPTp-SP users had significantly better pregnancy and foetal outcomes compared with non-users. Efforts should be intensified towards achieving total compliance in IPTp-SP usage by pregnant women.
Evaluation of prescription completeness, rational drug-use patterns using WHO prescribing, patient-care and facility indicators in Debre Tabor Comprehensive Specialized Hospital, Ethiopia: A cross-sectional study
Authors: Yimer Yohannes Shumet , Addis Getu Tesfaw , Alemu Muluken Adela 
Published: September 2022

Objective: Irrational medicine use results in diseases worsening, disability, death, and wastage of limited resources. This study was predominantly aimed to evaluate the rationality of medicine use patterns by assessing prescribing, patient-care, and facility indicators at Debre Tabor Comprehensive Specialized Hospital by using World Health Organization core drug use indicators. Methods: A cross-sectional design was conducted to collect prescribing indicator data from 780 prescriptions retrospectively from 1 July 2020 to 30 June 2021 at outpatient pharmacy of the hospital and exit interview was held prospectively on 150 patients to evaluate patient-care indicators. In addition, indicators for health-facility were assessed by actual observation of the presence of different guidelines. Descriptive analysis of the collected data was computed using SPSS version 25. Result: Totally, 1521 drugs were prescribed to 780 encounters. On average, 1.95 drugs were prescribed per prescription. Percentage of encounters by generic name, encounters with antibiotics and injection, and drugs from essential drug list were 99.9%, 35.4%, 15.3%, and 100%, respectively. From healthcare provider–related information, the names of prescribers and dispensers were correctly written in 93.59% and 77.69%, respectively. Frequency (97.18%) and route (86.15%) of drug administration were better stated in the reviewed encounters, whereas dosage form is poorly stated (7.44%). Labeling of dispensed medicine was obtained for only 10% of patients and patient knowledge for correct dose was 94%. Availability of facility indicators was 95%. Conclusion: From the results of this study, it is possible to conclude that the prescribing, patient-care, and facility indicators did not fulfill many World Health Organization standards. Therefore, it is important if all prescribers, dispensers, patients themselves, and the governing bodies take an action to improve the prescribing and patient-care indicators for the best of the end users.
Sharing of either phenotypes or genetic variants can increase the accuracy of genomic prediction of feed efficiency
Authors: Bolormaa Sunduimijid , MacLeod Iona M. , Khansefid Majid , Marett Leah C. , Wales William J. , Miglior Filippo , Baes Christine F. , Schenkel Flavio S. , Connor Erin E. , Manzanilla-Pech Coralia I. V. , Stothard Paul , Herman Emily , Nieuwhof Gert J. , Goddard Michael E. , Pryce Jennie E. 
Published: September 2022

Abstract
Background
Sharing individual phenotype and genotype data between countries is complex and fraught with potential errors, while sharing summary statistics of genome-wide association studies (GWAS) is relatively straightforward, and thus would be especially useful for traits that are expensive or difficult-to-measure, such as feed efficiency. Here we examined: (1) the sharing of individual cow data from international partners; and (2) the use of sequence variants selected from GWAS of international cow data to evaluate the accuracy of genomic estimated breeding values (GEBV) for residual feed intake (RFI) in Australian cows.

Results
GEBV for RFI were estimated using genomic best linear unbiased prediction (GBLUP) with 50k or high-density single nucleotide polymorphisms (SNPs), from a training population of 3797 individuals in univariate to trivariate analyses where the three traits were RFI phenotypes calculated using 584 Australian lactating cows (AUSc), 824 growing heifers (AUSh), and 2526 international lactating cows (OVE). Accuracies of GEBV in AUSc were evaluated by either cohort-by-birth-year or fourfold random cross-validations. GEBV of AUSc were also predicted using only the AUS training population with a weighted genomic relationship matrix constructed with SNPs from the 50k array and sequence variants selected from a meta-GWAS that included only international datasets. The genomic heritabilities estimated using the AUSc, OVE and AUSh datasets were moderate, ranging from 0.20 to 0.36. The genetic correlations (rg) of traits between heifers and cows ranged from 0.30 to 0.95 but were associated with large standard errors. The mean accuracies of GEBV in Australian cows were up to 0.32 and almost doubled when either overseas cows, or both overseas cows and AUS heifers were included in the training population. They also increased when selected sequence variants were combined with 50k SNPs, but with a smaller relative increase.

Conclusions
The accuracy of RFI GEBV increased when international data were used or when selected sequence variants were combined with 50k SNP array data. This suggests that if direct sharing of data is not feasible, a meta-analysis of summary GWAS statistics could provide selected SNPs for custom panels to use in genomic selection programs. However, since this finding is based on a small cross-validation study, confirmation through a larger study is recommended.