bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pictures from the Atomic Force Microscope: Temporal Representation in the Moving Image
Authors: Rassell Andrea 
Published: September 2022

Historically, artists and scientists predominantly created moving images of scientific phenomena using optical instrumentation such as cameras and light microscopes that enable direct observation of their subject. However, the perception and representation of nanoscale phenomena, which are too small to be detected by optical systems, rely upon complex technological mediation via layers of instrumentation, hardware and software. This mediation has profound implications for the perception of phenomena that exist outside the range of the human sensory system. This article describes the scientific representations of temporality in the work of Eadweard Muybridge and Étienne-Jules Marey and the complications of visualising the nanoscale. I analyse imperceptible phenomena in the contemporary moving image and draw upon my creative practice with the Atomic Force Microscope (AFM), using this instrument as a framework for discussing the temporal and sensorial challenges of working with nanoscale phenomena. This creative practice-based research resulted in the creation of several experimental moving image works collected under the title Wildly Oscillating Molecules. Through the adoption of scientific instrumentation and data for creative production, the collection of moving image practices discussed uncover temporal and sensorial assumptions and suggest alternative experiential encounters with scientific phenomena.
Prevalence of suspected poor bone health in people with chronic obstructive pulmonary disease – a cross-sectional exploratory study
Authors: Cecins Erin , Cavalheri Vinicius , Taaffe Dennis R , Hill Anne-Marie , Hug Sarah , Hill Kylie 
Published: September 2022

Background Compared to the general population, adults with chronic obstructive pulmonary disease (COPD) have an increased prevalence of osteoporosis. Despite the known risk factors and potential complications of compromised bone health in COPD, little is known about whether poor bone health is routinely suspected. We measured, in people with COPD, the prevalence of those who had one or more indicators suggestive of suspected poor bone health, and compared the characteristics of those with versus without these indicators. Methods Data were collected from adults with COPD presenting to three tertiary hospitals. Indicators of suspected poor bone health were defined as any of the following criteria: (i) self-reported problems with bone health, (ii) previous imaging for bone health, (iii) history of fragility fracture or, (iv) advised to use medication/supplements to optimise bone health. Characteristics compared between those with versus without indicators of suspected poor bone health comprised age, sex, body mass index (BMI), FEV1% predicted and recruitment setting. Results 361 participants were included (age 70 ± 10, BMI 27.9 ± 7.8 kg/m2, FEV1% predicted 49 ± 20; 161 [45%] female). Indicators suggestive of suspected poor bone health were present in 53% (95% confidence interval [CI] 47–58) of the participants. The odds of this outcome increased with advancing age (odds ratio; OR [95% CI] 1.05 [1.03 to 1.08]) and being female (OR [95% CI] 3.4 [2.2 to 5.7]) . Conclusion In people with COPD, the odds of having indicators suggestive of suspected poor bone health increase with advancing age and in females. Further work is required to promote the importance of bone health in this population.
The Exeter Activity Unlimited statement on physical activity and exercise for cystic fibrosis: methodology and results of an international, multidisciplinary, evidence-driven expert consensus
Authors: Williams Craig A , Barker Alan R , Denford Sarah , van Beurden Samantha B , Bianchim Mayara S , Caterini Jessica E , Cox Narelle S , Mackintosh Kelly A , McNarry Melitta A , Rand Sarah , Schneiderman Jane E , Wells Greg D , Anderson Peter , Beever Daniel , Beverley Z , Buckley Ronan , Button Brenda , Causer Adam J , Curran Máire , Dwyer Tiffany J , Gordon Warren , Gruet Mathieu , Harris Ryan A , Hatziagorou Elpis , (Erik) Hulzebos HJ , Kampouras Asterios , Morrison Lisa , Cámara Marietta N , Reilly Clare M , Sawyer Abbey , Saynor Zoe L , Shelley James , Spencer Grace , Stanford Gemma E , Urquhart Don S , Young Rachel , Tomlinson Owen W ,   on behalf of the Youth Activity Unlimited – A Strategic Research Centre of the UK Cystic Fibrosis Trust
Published: September 2022

Background The roles of physical activity (PA) and exercise within the management of cystic fibrosis (CF) are recognised by their inclusion in numerous standards of care and treatment guidelines. However, information is brief, and both PA and exercise as multi-faceted behaviours require extensive stakeholder input when developing and promoting such guidelines. Method On 30th June and 1st July 2021, 39 stakeholders from 11 countries, including researchers, healthcare professionals and patients participated in a virtual conference to agree an evidence-based and informed expert consensus about PA and exercise for people with CF. This consensus presents the agreement across six themes: (i) patient and system centred outcomes, (ii) health benefits, iii) measurement, (iv) prescription, (v) clinical considerations, and (vi) future directions. The consensus was achieved by a stepwise process, involving: (i) written evidence-based synopses; (ii) peer critique of synopses; (iii) oral presentation to consensus group and peer challenge of revised synopses; and (iv) anonymous voting on final proposed synopses for adoption to the consensus statement. Results The final consensus document includes 24 statements which surpassed the consensus threshold (>80% agreement) out of 30 proposed statements. Conclusion This consensus can be used to support health promotion by relevant stakeholders for people with CF.
Robotic Approach is Associated With a Lower Conversion Rate Compared to Laparoscopic Approach for Patients Undergoing Colectomy for T4b Colon Cancer. An Analysis of the National Cancer Database
Authors: Kamel Mohamed K. , Al-Qudah Ghaith , Shchatsko Anastasiya , Keane Charles A. , Serpa Eduardo , Nituica Cristina , Blebea John , Marar Omar 
Published: September 2022

Introduction We examined the perioperative outcomes of patients undergoing open, laparoscopic, or robotic colectomy for T4b colon cancer, as well as the clinical factors associated with conversion to an open approach and its consequences on perioperative and oncologic outcomes. Methods The National Cancer Database was queried for patients undergoing colectomy for cT4b colon cancer (2010-2016). Patients undergoing laparoscopic or robotic colectomy were matched using Propensity-Score analysis. Factors associated with conversion to an open approach were assessed using Logistic-regression multivariable-analysis (MVA). Results Colectomy for cT4b colon cancer was performed in 9030 patients (open: n = 6,543, robotic: n = 157, laparoscopic: n = 2330). In the propensity-matched groups, robotic approach had lower rate of conversion (12% vs 37%, P < .001), shorter hospital stays (5 vs 7-days, P = .02), and similar overall-survival (5-yr: 49% vs 39%, P = .16), compared to laparoscopic approach. Conversion to an open approach was noted in 801(32%) of the patients undergoing minimally invasive surgical colectomy (robotic n = 23(15%), laparoscopic n = 778(33%). Factors associated with lower rate of conversion on multivariable-analysis included recent year of surgery (95% CI: 0.88-.97), robotic approach (95% CI: 0.22-.56), and surgeries performed in Academic hospitals (95% CI: 0.65-.96). Conversion to an open approach was associated with higher rate of positive parenchymal margin (31% vs 25%, P = .001), higher rate of 30-day readmission (12% vs 9.5%, P = .04), and similar overall survival (5-yr: 32% vs 35%, P = .19), compared to those who had no conversion. Conclusion At the National level, patients undergoing colectomy for T4b colon cancer via a robotic approach had more favorable perioperative outcomes compared to laparoscopic approach. Conversion to an open approach did not compromise long term survival, despite being associated with higher rate of positive margins and readmissions rate.
Ulnar Resection Length: A Risk Factor for Nonunion in Ulnar Shortening Osteotomy
Authors: Pereira Gregory F. , Fletcher Amanda N. , O’Donnell Jeffrey A. , Whitlock Keith G. , Shapiro Lauren M. , Pidgeon Tyler S. , Ruch David S. , Richard Marc J. 
Published: September 2022

Background: Nonunion rates following ulnar shortening osteotomy (USO) are reported up to 18% with few known risk factors. While resection length is variable in practice, little is known about the prognostic implications on healing. The purpose of this study was to evaluate whether longer resection lengths increased the odds of nonunion. Methods: A retrospective review was performed on patients who underwent an elective USO at a single institution over a 6-year period. Demographic, social, comorbidity, and surgical data were reviewed. Ulnar resection length was obtained from operative notes and dichotomized into smaller (<5.5 mm) and larger (≥5.5 mm) groups. The primary outcome was the rate of nonunion. Univariate analyses and a multivariable logistic regression model were used to assess for significant predictors of nonunion. Results: A total of 87 patients were included with a mean age of 45 years. Patient comorbidities included 12.6% with diabetes, 29.9% with an American Society of Anesthesiologists score of ≥ 3, 5.8% reporting current tobacco use, and 29.9% reporting former tobacco use. There were 55 patients (63.2%) with resection lengths < 5.5 mm and 32 patients (36.8%) with ≥ 5.5 mm resections. Multivariable analysis identified longer resection length (≥5.5 mm) and current tobacco use as independent risk factors for nonunion. Patients with a resection length of ≥ 5.5 mm had 20.2 times greater odds of nonunion compared with patients with smaller resections, and current smokers had 72.2 times greater odds of nonunion compared with nonsmokers. Conclusion: Longer ulnar resection length (≥5.5 mm) significantly increases the risk of nonunion following USO.
Erythropoietin-producing hepatocyte kinase receptor A1 facilitating the prgression of SGC-7901 cells and its transplanted tumor by increasing the expression of interleukin-6 and vascular endothelial growth factor in tumor microenvironment
Authors: Wang Yong-Cang , Zheng Wen-Lin , Yu Wei , Quan Rui-Liang , Zhao Ya-Jun 
Published: September 2022

Objectives Many researches showed that Erythropoietin-producing hepatocyte kinase receptor A1 (EphA1) can promote the occurrence and development of malignant tumors and may be related to tumor microenvironment. But most of them are phenomenon studies, and there are few in-depth and complete mechanism studies. This study aims to understand how EphA1 promotes the progression of malignant tumors by regulating tumor microenvironment (focusing on Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF)) from two experimental dimensions of in vitro and in vivo by using genetic engineering technology. Material and Methods We used genetic engineering technology to enhance and knock down EphA1 gene expression in SGC-7901 cells, respectively, and analyzed its influence on cell function and the expression levels of VEGF and IL-6 in cells. Subsequently, we constructed human EphA1 gene overexpression, EphA1 gene silencing, and normal expression of human EphA1 gene subcutaneous transplanted tumor models of SGC-7901 cells nude mice, and analyzed the differences in tumor development and the changes in the expression levels of VEGF and ILl-6 in tumor tissues. Results After EphA1 gene expression was enhanced, the proliferation, invasion and migration of SGC-7901 cells were enhanced, and apoptosis was weakened, and the expression levels of VEGF and IL-6 were increased. While the opposite results were found when EphA1 gene expression were knocked down. Meanwhile, tumor formation time and growth rate of subcutaneous transplantation in nude mice were advanced and the expression levels of VEGF and IL-6 in tumor tissues were increased when EphA1 gene expression were overexpressed by genetic engineering technology. Similarly, the opposite effect occurred in transplanted tumor model when EphA1 gene was silenced. Conclusion Our study showed that EphA1 can up-regulating VEGF and IL-6 expression, thereby enhancing the inflammatory environment and angiogenesis in the tumor microenvironment, and this helps to promote the progression of SGC-7901 cells and its transplanted tumor.
Unilateral versus bilateral reconstructive hip surgery in children with cerebral palsy: A survey of pediatric orthopedic surgery practice and decision-making
Authors: Miller Stacey D , Juricic Maria , Baraza Njalalle , Fajardo Nandy , So Judy , Schaeffer Emily K , Shore Benjamin J , Narayanan Unni , Mulpuri Kishore 
Published: September 2022

Purpose: This study explored whether surgeons favor unilateral or bilateral reconstructive hip surgery in children with cerebral palsy who have unilateral hip displacement. Methods: An invitation to participate in an anonymous, online survey was sent to 44 pediatric orthopedic surgeons. The case of an 8 year old at Gross Motor Function Classification System level IV with migration percentages of 76% and 22% was described. Surgeons selected their surgical treatment of choice and provided their rationale. Respondents were also asked to list and rank radiographic parameters used for decision-making and multidisciplinary team members involved in decision-making. Results: Twenty-eight orthopedic surgeons from nine countries with a mean 21.3 years (range, 5–40 years) of experience completed the survey. A “bilateral VDROs with a right pelvic osteotomy (PO) was selected by 68% (19/28) of respondents; risk of contralateral subluxation (9/19; 47%) and maintaining symmetry (7/19; 37%) were the most common rationales for bilateral surgery. The remaining 32% (9/28) chose a ‘right VDRO with a right PO’” with most of these (8/9; 89%) stating the left hip was sufficiently covered. Of 31 radiographic parameters identified, migration percentage, acetabular angle/index, Shenton line, neck shaft angle, and presence of open/closed triradiate growth plates were the most common. Physical therapists (68%) and physiatrists (43%) were most likely to be involved in pre-operative surgical consultation. Conclusion: There is a lack of agreement on management of the contralateral hip in children with unilateral hip displacement. Further studies comparing patient important outcomes following unilateral and bilateral surgery are required. Level of Evidence: V
Mechanical testing of frontal plane adaptability of commercially available prosthetic feet
Authors: Wernke Matthew M , Ficanha Evandro M , Thomas Zac , Maitland Murray E , Allyn Katheryn J , Albury Alex , Colvin James 
Published: September 2022

Introduction Prosthetic feet have limited adaptability in the frontal plane. Research shows walking on uneven terrain is difficult for many prosthesis users. A new prosthetic foot, the META Arc, was designed with a polycentric ankle joint that allows relatively free movement in the frontal plane to address this limitation. Previous simulations of the polycentric ankle mechanism found potential benefits such as reduced lateral movement of a proximal mass during forward progress and reduced forces being transferred upward from the ground through the foot. Methods Standard mechanical testing protocols were used to evaluate the Meta Arc prosthetic foot’s performance and six comparable feet commercially available. Results The results found the META Arc prosthetic foot had increased frontal plane adaptability as well as reduced lateral forces, and reduced inversion eversion moment compared to the six comparison feet on 10-degree cross-slope test conditions. All included prosthetic feet had similar results for the percent of energy return and dynamic force in the sagittal plane. Conclusions These results suggest the inclusion of the polycentric ankle within the META Arc foot will provide more stability without sacrificing forward walking performance.
Designing a Surveillance System to Monitor the Adverse Health Effect of Environmental Disasters: A Case Study of Drying Lake Urmia-Iran
Authors: Gharaee Hojatolah , Dewey Rebecca Susan , Rezapour Ramin , Derakhshani Naser , Azami-aghdash Saber 
Published: September 2022

Background Through designing a surveillance system, steps to policy making and designing measures needed to reduce the potential risks of environmental disasters on human health could be taken. Therefore, this study aimed to develop a model for Environmental Disasters Diseases Surveillance System (EDDS) to monitor Adverse Health Effects (AHEs) of Environmental Disasters (AHEEDs). Methods As the first step, the literature review was conducted to identify the AHEEDs. Then, using the results of the first step and analyzing the existing documents, the AHEEDs were identified, and, based on the experts’ opinions, high-priority effects were included in the EDDS. Then, using semi-structured interviews, 20 experts’ views on the appropriate model of EDDS were investigated. To design the initial model, a panel of experts was formed with six participants. Finally, the Delphi technique was used for expert opinion and model finalization. Results As a result of the literature review and document analysis, 41 hazards/diseases were identified. Finally, ten diseases were suggested to enter the EDDS. In the experts’ view, it is better that communicable diseases be reported actively and urgently and Non-Communicable Diseases (NCD) actively and non-urgently. From the participants’ point of view, the most significant achievements of the EDDS can be organizational and managerial, health promotion, and economic achievements. Conclusion Developing a dedicated EDDS for AHEEDs can be very helpful for better management of these effects. To this end, the model proposed in this study can serve as a guide for national and local policymakers to implement surveillance systems for AHEEDs.
Workforce Development to Improve Access to Pain Care for Veterans: A Qualitative Analysis of VA-ECHO Participant Experiences
Authors: Subramaniam Soumya , Stryczek Krysttel C. , Ball Sherry , Stevenson Lauren , Ho P. Michael , Aron David C. 
Published: September 2022

Background/Objective The prevalence of chronic pain and its links to the opioid epidemic have given way to widespread aims to improve pain management care and reduce opioid use, especially in rural areas. Pain Management Specialty Care Access Network-Extension for Community Health Outcomes (VA-ECHO) promotes increased pain care access to rural Veterans through knowledge sharing from specialists to primary care providers (PCPs). We explored PCP participants’ experiences in VA-ECHO and pain management care. Methods This qualitative study is based on a descriptive secondary analysis of semi-structured interviews (n = 10) and 3 focus groups with PCPs participating in VA-ECHO from 2017–2019. A rapid matrix analysis approach was used to analyze participants’ responses. Results VA-ECHO was an effective workforce development strategy for meeting PCPs’ training needs by providing pain management knowledge and skills training (eg alternative care approaches and communicating treatment options). Having protected time to participate in VA-ECHO was a challenge for many PCPs, mitigated by leadership and administrative support. Participants who volunteer to participate had more positive experiences than those required to attend. Conclusions VA-ECHO could be used for meeting the workforce development needs of PCPs. Respondents were satisfied with the program citing improvement in their practice and increased confidence in providing pain management care to Veterans despite some challenges to participation. These findings offer insight into using VA-ECHO to meet the VHA’s workforce development to improve Veterans’ access to pain management care. The ECHO model presents opportunities for workforce development in large complex healthcare systems and garnering ongoing support for this training model is necessary for promoting workforce development for PCPs.
Depression Among Patients with Chronic Pain, in Jimma Town Public Hospitals, Ethiopia
Authors: Serawit Tigist , Belay Yeshitila , Tesfaye Yonas , Mekoya Tsion , Yimam Ebrahim 
Published: September 2022

Introduction The co-occurrence of depression and chronic pain causes additive adverse effects on patients” outcomes, response to treatment, and poorer functioning. Despite this, there is a dearth of studies in developing countries. Therefore, this study aimed to provide a new insight into the understanding of the prevalence and associated factors between chronic pain and depression among patients with chronic pain in Jimma town public hospitals. Methods Institution-based cross-sectional study was conducted in Jimma town public hospitals. A total of 422 sampled patients with chronic pain participated in the study. Depression was assessed using the PHQ-9 scale. The coded data were entered to Epi Data version 3.1 and exported into SPSS version 23.0 for analysis. Logistic regression analysis model was used to identify factors independently associated with depression. Result The prevalence of depression among chronic pain patients was found to be 43.3%. The number of presenting compliant (AOR = 3.092, 95% CI: 1.684-5.678), history of depression (AOR = 0.319, CI: 0.133-0.766), pain intensity (AOR = 5.296, 95% CI: 2.018-13.901), pain location (AOR = 0.318, 95% CI: 0.158-0.638), pain persistence (AOR = 5.163, 95% CI: 2.784-9.576), the extent the pain compromised the respondent quality of life (AOR = 3.816, 95% CI: 1.685-8.643), and episodes of the pain associated with activities (AOR = 0.247, 95% CI: 0.138-0.442) were significantly associated with depression among patients with chronic pain. Conclusion This study has shown a high prevalence of depression among patients with chronic pain. Furthermore, depression was associated with various pain-related factors. Hence, effective screening and management of depression among chronic pain patients’ needs noteworthy attention.