bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frailty: understanding the difference between age and ageing
Authors: Gordon Emily H , Hubbard Ruth E 
Published: August 2022

Abstract
In the past, illness and dependence were viewed as inevitable consequences of old age. Now, we understand that there is a difference between age (the passing of chronological time) and ageing (the increased risk of adverse outcomes over time). Over the last 50 years, ‘frailty’ research has established that ageing is heterogeneous, variable and malleable. Significant advances have been made in frailty measurement (description of clinical features and development of clinical models), mechanisms (insights into pathogenesis) and management (development of interventions to reduce and/or prevent progression). Subsequently, the concept of frailty has informed health policy and clinical practice and started to change perceptions of older age held by the general public and the health sector. Here, we overview key achievements in frailty research and clinical practice and highlight the considerable number of known unknowns that may be addressed in the future.
Introducing stimulogenetics, unraveling pertinent semantic ambiguity, and determining clinical relevance among novel neuromodulation strategies
Authors: Garg Pranjal , Muthiah Saidharshini , Sengupta Sumedha 
Published: August 2022

Abstract
Deep brain stimulation involving the stereotactic implantation of electrodes in the deeper neural tissue remains one of the most trusted nonpharmacotherapeutic approaches for neuromodulation in the clinical setting. The recent advent of techniques that can modulate the neural structure and/or function at the cellular level has stimulated the exploration of these strategies in managing neurological and psychiatric disorders. Optogenetics, which is widely employed in experimental research, is the prototype of the above techniques. Other methods such as chemogenetics, sonogenetics, and magnetogenetics have also been introduced. Although these strategies possess several noticeable differences, they have an overlapping conceptual framework enabling their classification under a singular hypernym. This article introduces this hypernym, “stimulogenetics” in an attempt to solve the pertinent ambiguity to aid the classification of existing literature. The article also compares the strategies classified under stimulogenetics and concludes that the current literature suggests that nonsurgical approaches such as chemogenetics and sonogenetics are better suited for clinical applications. However, due to the dearth of clinical studies, it is not possible to determine this definitively.
Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis
Authors: Herrod Philip J J , Kwok Alex T , Lobo Dileep N 
Published: August 2022

AbstractBackgroundThis aim of this study was to provide an updated meta-analysis comparing antibiotic therapy with appendicectomy in adults (16 years or older) with uncomplicated acute appendicitis.MethodsA search for randomized clinical trials comparing antibiotic therapy with appendicectomy in adults with uncomplicated acute appendicitis from inception to 3 October 2021 in MEDLINE, Embase and CENTRAL with no language constraints was performed. Studies were excluded if they included paediatric participants or those with complicated appendicitis. Data on complications of treatment, treatment efficacy (defined in the antibiotic group as not undergoing appendicectomy within 1 year of enrolment, versus surgery without complications or no negative histology in the appendicectomy group), readmissions, and length of stay (LOS) were presented.ResultsEight RCTs involving 3203 participants (1613 antibiotics/1590 appendicectomy; 2041 males/1162 females) were included. There was no significant benefit of antibiotic treatment on complication rates (risk ratio (RR) 0.66, 95 per cent c.i. 0.41 to 1.04). Antibiotics had a reduced treatment efficacy compared with appendicectomy (RR 0.75, 95 per cent c.i. 0.63 to 0.89). Antibiotic treatment at 1 year was successful in 1016 of 1613 (62.9 per cent) participants. There was a six-fold increase in hospital readmissions within 1 year of enrolment in participants receiving antibiotic treatment (RR 6.28, 95 per cent c.i. 2.87 to 13.74). There was no difference in index admission LOS (mean difference 0.15 days (95 per cent c.i. −0.05 to 0.35)).ConclusionsEarlier optimism regarding the benefits of antibiotic therapy for uncomplicated acute appendicitis does not persist at the same level now that further, large trials have been included. If antibiotic treatment is to be offered routinely as first-line therapy, patients should be counselled appropriately.
Workplace exposure to UV radiation and strategies to minimize cancer risk
Authors: Cherrie J W , Cherrie M P C 
Published: August 2022

Abstract

Background
Workplace exposure to solar ultraviolet (UV) causes malignant melanoma and non-melanoma skin cancer. The evidence for beneficial effects of solar UV exposure in reducing the risks for other cancers is increasing. The intensity of UV radiation at the Earth’s surface is dependent on latitude, but even in northern European countries exposure can be high enough for outdoor work to cause skin cancer.

Growing points
Awareness of the health risks and benefits of occupational solar UV exposure is poor. Actions to reduce the risk of skin cancer have been identified and employers should recognize their responsibility to actively manage these risks. There is evidence for reduced risks for breast, ovarian and colorectal cancer and possibly other cancers linked to solar UV exposure.

Sources of data
This narrative review draws on published scientific articles and material designed to assist identifying strategies to protect workers from solar UV exposure.

Areas of agreement
Solar UV exposure can be harmful. Wavelengths in the UVB range are more effective in causing erythema and DNA damage. Solar UV is the main source of vitamin D for most people. Primary and secondary prevention for skin cancer can potentially eliminate these risks but the evidence for effectiveness is limited.

Areas of controversy
Potential health benefits of UV exposure, particularly for reduced cancer risk. Determining and communicating optimal exposure to maximize health benefits. The risk of non-melanoma skin cancers may be more than doubled for some workers in temperate latitudes.

Areas timely for developing research
Exposure-response epidemiological studies; studies of the health benefits of occupational UV exposure; studies of the effectiveness of intervention strategies to prevent skin cancer. Use of low-cost UV sensors in workplaces.
Neurophysiological evidence for goal-oriented modulation of speech perception
Authors: Chai Xiaoke , Liu Min , Huang Ting , Wu Meiyun , Li Jinhong , Zhao Xue , Yan Tingting , Song Yan , Zhang Yu-Xuan 
Published: August 2022

AbstractSpeech perception depends on the dynamic interplay of bottom-up and top-down information along a hierarchically organized cortical network. Here, we test, for the first time in the human brain, whether neural processing of attended speech is dynamically modulated by task demand using a context-free discrimination paradigm. Electroencephalographic signals were recorded during 3 parallel experiments that differed only in the phonological feature of discrimination (word, vowel, and lexical tone, respectively). The event-related potentials (ERPs) revealed the task modulation of speech processing at approximately 200 ms (P2) after stimulus onset, probably influencing what phonological information to retain in memory. For the phonological comparison of sequential words, task modulation occurred later at approximately 300 ms (N3 and P3), reflecting the engagement of task-specific cognitive processes. The ERP results were consistent with the changes in delta-theta neural oscillations, suggesting the involvement of cortical tracking of speech envelopes. The study thus provides neurophysiological evidence for goal-oriented modulation of attended speech and calls for speech perception models incorporating limited memory capacity and goal-oriented optimization mechanisms.
A case series of desmoplakin cardiomyopathy: a mimic of viral myocarditis
Authors: Rezaei Bookani Kaveh , Minga Iva , Wodskow Joshua , Harris Jordan , Gordon Robert , Sarswat Nitasha , Pursnani Amit 
Published: August 2022

Abstract

Background
Clinical features and imaging presentation of myocarditis can overlap with other inflammatory or arrhythmogenic cardiomyopathies. Desmoplakin (DSP) is an important structural cardiac protein. Mutations in the DSP gene are associated with a variant of arrhythmogenic right ventricular cardiomyopathy (ARVC). Interestingly, this distinct genetic cardiomyopathy can also present with a myocardial inflammation and fibrosis pattern that may mimic other forms of myocarditis including viral myocarditis, which can raise a clinical challenge. We report two cases of DSP cardiomyopathy, which were initially thought to represent coronavirus disease of 2019 (COVID-19) myocarditis.

Case summary
First patient is a 21-your-old woman with no past medical history but family history of presumed ‘viral myocarditis’ and ventricular tachycardia in her brother. She presented with acute chest pain and elevated cardiac enzymes. She tested positive for COVID-19 and given the suspicion for possible COVID-19 related acute myocarditis, cardiac magnetic resonance imaging obtained and revealed regional wall motion abnormalities, several areas of subepicardial and pericardial late gadolinium enhancement (LGE). Ambulatory cardiac monitoring showed runs of non-sustained ventricular tachycardia and considering her family history of arrhythmogenic myocarditis, genetic testing was performed that was positive for a likely pathogenic heterozygous mutation of DSP gene. She declined the recommended implantable cardioverter defibrillator (ICD).
Second patient is a 34-year-old physician with no significant past medical history who works at a COVID-19 unit and presented with syncope and was found to have ventricular tachycardia. Echocardiogram revealed severely dilated left ventricle and globally depressed systolic function with left ventricular ejection fraction of 20%. Coronary computed tomography angiography showed no evidence of coronary atherosclerosis. Cardiac magnetic resonance imaging revealed several areas of mid myocardial and pericardial LGE. Subcutaneous ICD was implanted and an endomyocardial biopsy had evidence of lymphocytic myocarditis and adipose tissue infiltration of the myocardium. Genetic testing revealed pathogenic heterozygous DSP mutation. He underwent epicardial ablation for the episodes of ventricular tachycardia despite medical therapy. He was able to return to work and has not had any further episodes of arrhythmia.

Conclusion
Mutations in the DSP gene are associated with left dominant arrhythmogenic cardiomyopathy, which is a variant of ARVC. Beside left ventricular systolic dysfunction and ventricular tachyarrhythmias, carriers of these mutations may present with episodes of chest pain associated with elevated cardiac enzymes and cardiac imaging findings indistinguishable from other forms of acute myocarditis including viral myocarditis. Currently, there are no guidelines for diagnosis and treatment of this entity.
Demystifying non-coding GWAS variants: an overview of computational tools and methods
Authors: Schipper Marijn , Posthuma Danielle 
Published: August 2022

AbstractGenome-wide association studies (GWAS) have found the majority of disease-associated variants to be non-coding. Major efforts into the charting of the non-coding regulatory landscapes have allowed for the development of tools and methods which aim to aid in the identification of causal variants and their mechanism of action. In this review, we give an overview of current tools and methods for the analysis of non-coding GWAS variants in disease. We provide a workflow that allows for the accumulation of in silico evidence to generate novel hypotheses on mechanisms underlying disease and prioritize targets for follow-up study using non-coding GWAS variants. Lastly, we discuss the need for comprehensive benchmarks and novel tools for the analysis of non-coding variants.
Planning and scheduling of a parallel-machine production system subject to disruptions and physical distancing
Authors: Bazargan-Lari Mohammad Reza , Taghipour Sharareh , Zaretalab Arash , Sharifi Mani 
Published: August 2022

Abstract
This paper aims to quantify the effects of production disruptions (PDs) and physical distancing constraints due to the pandemic in a parallel-machine production environment. The machines are non-identical and are utilized for producing a finite set of jobs (parts) in a plastic injection moulding production. The production process is subjected to random production downtime disruptions. A mixed-integer linear programming (MILP) model is developed for optimizing the joint production plan and schedule, which maximizes the production’s total benefit. The model is utilized to plan and schedule a set of 17 machines in a Canadian manufacturing company. To explore the effects of physical distancing and PDs on the production’s total net profit, four different scenarios for normal operation and production during the pandemic, with and without production downtimes, are considered. A genetic algorithm is utilized to solve the model. The results show that considering machines’ random breakdowns and physical distancing individually reduces the total profit of the production by 71.58 and 57.98%, respectively; while their joint effect results in a 88.54% reduction in the annual net profit.
Clonal dissemination of carbapenem-resistant Klebsiella pneumoniae ST16 co-producing NDM-1 and OXA-232 in Thailand
Authors: Abe Ryuichiro , Akeda Yukihiro , Takeuchi Dan , Sakamoto Noriko , Sugawara Yo , Yamamoto Norihisa , Kerdsin Anusak , Matsumoto Yuki , Motooka Daisuke , Leolerd Warawut , Santanirand Pitak , Suzuki Masato , Shibayama Keigo , Tomono Kazunori , Iida Tetsuya , Hamada Shigeyuki 
Published: August 2022

Abstract

Background
Klebsiella pneumoniae ST258 and ST11 carrying blaKPC are among the most widespread carbapenem-resistant K. pneumoniae strains worldwide. Our carbapenem-resistant Enterobacteriaceae surveillance in Thailand revealed a nationwide dissemination of K. pneumoniae ST16 isolates carrying blaNDM-1 and blaOXA-232.

Objectives
To analyse the genomic details of this nationwide dissemination by focusing on plasmids and virulence factors.

Methods
Using WGS data of 119 K. pneumoniae ST16 isolates carrying blaNDM-1 obtained in our previous surveillance study, clonality of chromosomes and plasmids of the isolates with carriage of virulence factors was evaluated.

Results
Of the 119 isolates, 111 carried plasmid pKP151_NDM1, and all 104 isolates harbouring blaOXA-232 carried plasmid pKP151_OXA232. These 104 K. pneumoniae ST16 isolates showing chromosomal clonality possessed both pKP151_NDM1 and pKP151_OXA232, demonstrating clonal dissemination of K. pneumoniae ST16 with these plasmids. The isolates had essentially similar virulence factors as those of K. pneumoniae ST16 clones carrying blaKPC, which were recently reported as highly invasive clones in Brazil.

Conclusions
The potential global dissemination of these invasive clones with resistance to several antibiotics highlights the importance of appropriate monitoring and strict standard precautions.
Ovarian development of the crabEriphia gonagra(Fabricius, 1781) (Decapoda: Brachyura: Eriphiidae) in northeastern Brazil
Authors: Rios Aline S , Shinozaki-Mendes Renata A , Santana Julianna L , Souza-Filho Jesser F 
Published: August 2022

AbstractWe describe the development and maturation of the germ cells of the brachyuran crab Eriphia gonagra (Fabricius, 1781). Monthly collections were conducted in Pernambuco state, northeastern Brazil, from November 2018 to October 2019 during the low spring tide. The anatomy of the reproductive system of female individuals follows the basic brachyuran pattern. Five cell developmental stages were identified based on the morphological changes in the developmental stages: oogonia (7.10 ± 1.85 µm), pre-vitellogenic oocytes (42.23 ± 8.61 µm), oocytes in initial vitellogenesis (130.49 ± 21.93 µm), vitellogenic oocytes (139.68 ± 23.45 µm), and mature oocytes (214.77 ± 90.81 µm). Developmental stages were defined and related to gonad coloration and germ- cell development; five maturational stages were identified: immature, initial maturation, advanced maturation, mature, and spawning/resting.
MiFID II and the Regulation of Multilateral Trading in OTC Derivatives: Is the OTF Fit for Purpose?
Authors: Helm Simon 
Published: August 2022

Abstract
This article identifies barriers to the complete implementation of the organized trading facility (OTF) as a new category of trading venue under the Markets in Financial Instruments Directive (Directive 2014/65/EU) (MiFID II). It argues that attempts to reconcile the competing claims of incumbent regulated markets and dealer banks operating broker crossing networks in the cash securities markets led to a market design that is not suitable for the over-the-counter (OTC) derivatives markets. The result has been that multilateral trading in the wholesale secondary markets has not been incorporated in trading venues, as was intended, and that changes that are better aligned to market requirements are needed. These include reform of requirements transposed from the cash securities markets, such as standardized fee structures, and relaxation of restrictions on interactions between an OTF and other OTFs or systematic internalizers.
The elusive triple win: addressing temporary labour migration dilemmas through fair representation
Authors: Bauböck Rainer , Ruhs Martin 
Published: August 2022

Abstract
Temporary Labour Migration Programmes (TLMPs) are controversial because they are caught in a dilemma between global and domestic justice. From a global justice perspective, TLMPs expand opportunities for workers in poor countries to access labour markets of rich countries and they improve the situation of origin countries through remittances. From a domestic justice perspective, TLMPs violate principles of domestic equality because they always afford migrant workers more restricted rights than those enjoyed by citizens and long-term residents of the host country. Although this dilemma cannot be fully resolved, we argue that TLMPs can be morally justified and recommended if they are characterised by ‘fair representation’ in policy design and implementation and also meet certain democratic legitimacy conditions. TLMPs can be justified if they provide triple benefits for destination and origin countries as well as for migrants themselves, yet the relevant benefits can only be achieved cooperatively through transnational governance in which each of the three groups of actors is fairly represented. This conclusion is supported by our interpretation of the democratic principle of including all affected interests. Under such conditions, some rights of temporary migrant workers in host countries can be regarded as a legitimate outcome of negotiations, while others need to be fixed in advance under a democratic principle of equal protection of all subjected to the laws. Democratic legitimacy also requires that migrants enjoy protection and participation rights as citizens of their countries of origin as well as local citizenship in their countries of residence.
Clinical Features, Survival, and Burden of Toxicities in Survivors More Than One Year After Lung Cancer Immunotherapy
Authors: Hsu Melinda L , Murray Joseph C , Psoter Kevin J , Zhang Jiajia , Barasa Durrant , Brahmer Julie R , Ettinger David S , Forde Patrick M , Hann Christine L , Lam Vincent K , Levy Benjamin , Marrone Kristen A , Patel Tricia , Peterson Valerie , Sagorsky Sarah , Turner Michelle , Anagnostou Valsamo , Naidoo Jarushka , Feliciano Josephine L 
Published: August 2022

Abstract

Introduction
Anti-PD-(L)1 immune checkpoint inhibitors (ICI) improve survival in patients with advanced non-small cell lung cancer (aNSCLC). The clinical features, survival, and burden of toxicities of patients with aNSCLC alive &gt;1 year from ICI initiation are poorly understood.

Materials and Methods
We defined ICI survivors as patients alive &gt;1 year after ICI start and retrospectively reviewed demographics, treatment, and immune-related adverse events (irAEs). Long-term irAEs were defined as ongoing irAEs lasting &gt;1 year; burden of toxicity measures were based on percentage of days a patient experienced toxicity. Using linear and logistic regression, we evaluated association between demographics and disease characteristics with burden of toxicity.

Results
We identified 114 ICI survivors from 317 patients with aNSCLC. Half (52%) experienced an irAE of any grade, and 23.7% developed long-term irAEs. More ICI survivors with irAES in the first year had never smoked (P = .018) or received ICIs as frontline therapy (P = .015). The burden of toxicity in the first year significantly correlated with the burden of toxicity afterward (ρ = 0.72; P &lt; .001). No patients with progressive disease had a high burden of toxicity, and they experienced 30.6% fewer days with toxicity than those with stable disease. Increased duration of therapy was associated with higher odds of experiencing toxicity. Half of ICI survivors with irAEs were still receiving treatment for unresolved irAEs at time of death or last follow-up.

Conclusion
Significant proportions of ICI survivors have unresolved long-term toxicities. These data support a growing need to understand long-term toxicity to optimize management of those treated with ICIs.
An Integrated Care Model for Pregnant and Postpartum Individuals Receiving Medication for Opioid Use Disorder
Authors: Ellis Laura Peyton , Parlier-Ahmad Anna Beth , Scheikl Marjorie , Martin Caitlin E. 
Published: August 2022

Objectives
Perinatal opioid use disorder is increasing. Integrated obstetric/addiction care models likely optimize parent-infant dyad outcomes, but the ideal combination of services is unknown. This study (1) describes pregnancy-to-postpartum service utilization by people receiving buprenorphine at an integrated Obstetric/Addiction Clinic and (2) explores the association between service utilization and postpartum buprenorphine continuation.

Methods
This retrospective medical record review study uses research registry data from an outpatient Obstetric/Addiction Clinic. All patients are invited to participate in the research registry. For patients who consent, monthly medical record abstractions are conducted beginning with their first clinic visit to collect demographic, obstetric, and substance use disorder treatment variables. Present analyses included patients who delivered an infant between June 2019 and June 2021, started buprenorphine during pregnancy, and were receiving buprenorphine at delivery. Overall service utilization was the number of services (range 0–12) used between 28-weeks gestation and 12-weeks postpartum. Bivariate analyses and multivariable logistic regression assessed associations between service utilization and buprenorphine continuation.

Results
Participants (n = 42) were primarily non-Latinx White (67%) with comorbid psychiatric diagnoses (95%). On average, participants used 6 services; prenatal care, mental health care, and postpartum contraception were most utilized. Overall, 69% of participants continued buprenorphine at 6 months postpartum. This did not differ by level of service utilization (bivariate [P = 0.07], multivariable [P = 0.16]).

Conclusion
Integrated care with a harm reduction focus supports pregnancy-to-postpartum service utilization and buprenorphine continuation in a patient sample at high risk for medication for opioid use disorder discontinuation. Further work is needed to identify evidence-based methods to individualize integrated obstetric/addiction care.