bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long Run Predictions Using Gompertz Curves- A State Wise Analysis of COVID -19 Infections in India
Authors: ADHIKARY ABHIGAYAN , Pal Manoranjan 
Published: October 2022

Abstract
The aim of this paper is to perform a State wise Analysis of the First and the Second Covid Waves experienced by India using the Gompertz Curves and to estimate the maximum number of affected individuals for each wave with the best possible accuracy. A total of 21 large States are chosen for the analysis encompassing 97% of the Indian population. Data on cumulative number of cases is available till 31st October 2021. The entire dataset is segregated into two parts, i.e., the First and the Second Waves and then modelled individually by the Gompertz Curves with some generalizations.
The predicted maximum cumulative numbers of Covid-19 affected individuals are found to be quite accurate. Besides, it is found to be possible to give a methodology how one can predict these numbers with a much smaller dataset. This is important as it can help the authorities in taking an informed decision on the efficient allocation of the limited health care resources.
JEL Classification: E0, C32, C50, C53
The Effect of Telephone Counseling on COVID-19-related Health Anxiety in Pregnant Women: A randomized controlled trial
Authors: Yazdi Sahar , Saeedi Maryam , Taleb Sahar 
Published: October 2022

Abstract
Background
This study aimed to investigate the effect of telephone counseling on COVID-19-related health anxiety in pregnant women.
Methods
The present research was a randomized controlled trial. Eighty pregnant women were randomly selected and assigned to the control and intervention groups. The intervention group received telephone counseling for one month. Health anxiety was assessed using a health anxiety questionnaire. One month following the intervention, the mean score of health anxiety showed a statistically significant difference between the control and intervention groups (P <0.001).
Results
The mean score of health anxiety was 23.57 ± 3.55 in the intervention group, which was significantly lower than the mean health anxiety score of the control group (30.1 ± 5.93). In addition, there was a statistically significant difference between the mean health anxiety scores before and after telephone counseling in the intervention group (P <0.001).
Conclusion
Based on the findings of this study, telephone counseling can play a major role in reducing COVID-19-related health anxiety in pregnant women. So, this method can be utilized to prevent mothers’ physical and psychological problems during the COVID-19 outbreak.
Trial registration
This study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code “IRCT20220531055038N1” on 13/06/2022.
Multi-species Ion Acceleration in 3D Magnetic Reconnection
Authors: Zhang Qile , Guo Fan , Daughton William , Li Hui , Le Ari , Phan Tai , Desai Mihir 
Published: October 2022

Abstract
Magnetic reconnection drives explosive particle acceleration in a wide range of space and astrophysical applications. The energized particles often include multiple species (electrons, protons, heavy ions), but the underlying acceleration mechanism is poorly understood. In-situ observations of these minority heavy ions offer a more stringent test of acceleration mechanisms, but the multi-scale nature of reconnection hinders studies on heavy-ion acceleration. Here we employ hybrid simulations (fluid electron, kinetic ions) to capture 3D reconnection over an unprecedented range of scales. For the first time, our simulations demonstrate nonthermal acceleration of all available ion species into power-law spectra. The reconnection layers consist of fragmented kinking flux ropes as part of the reconnection-driven turbulence, which produces field-line chaos critical for accelerating all species. The upstream ion velocities influence the first Fermi reflection for injection. Then lower charge/mass species initiate Fermi acceleration at later times as they interact with growing flux ropes. The resulting spectra have similar power-law indices $(p\sim4.5)$, but different maximum energy/nucleon $\propto($charge/mass$)^\alpha$, with $\alpha\sim0.6$ for low plasma $\beta$, and with $p$ and $\alpha$ increasing as $\beta$ approaches unity. These findings are consistent with observations at heliospheric current sheets and the magnetotail, and provide strong evidence suggesting Fermi acceleration as the dominant ion-acceleration mechanism.
The organic carbon stocks in the soil in the Climato-Intelligent and Conventional Systems of the Nawa Region, Ivory Coast.
Authors: YOUSSOUF TOURE , Onawumi Olufisayo Adeyinka 
Published: October 2022

Abstract
Cocoa production has long been thought to be a cause of forest loss and thus an environmental issue.
Cocoa sustainability systems, particularly agroforestry systems, are being investigated as a means of mitigating climate change through carbon sequestration. However, most agroforestry research has concentrated on forest management and cacao yield, and soil organic carbon (SOC) reserves are little understood.
In the South West Region (NAWA) of Cote d'Ivoire, we undertook a study to quantify and compare soil organic carbon stocks in cocoa sustainability systems (agroforestry, organic fertilizer use, etc.) and traditional cocoa farming. Soil samples were taken at three different depths: 0-15 cm, 15-30 cm, and 30-45 cm, and examined according to normal soil testing protocols. SOC was found to be higher in plantations where farmers practiced sustainability programs than in plantations where farmers did not practice sustainability programs.
According to the study, a farmer who grows cocoa intercropped with shade trees (fruit and non-fruit) on his plot is more likely to gain from soil carbon credits than a farmer who grows conventional cocoa.
If farmers farming sustainable cocoa grew shade trees and employed organic fertilizers, they would be able to trap more carbon.
Incentives are needed to stimulate the planting and maintenance of shade trees, as well as the use of organic fertilizers in cocoa farms for carbon sequestration purposes.
Tooth eruption and caries patterns in the first permanent molars of 6–8-year-old schoolchildren in Shenzen, China
Authors: Fang Jiaying , Zhong Qi-Zhi , Liu Zheng , Guo Yan-Fang , Ding Zan 
Published: October 2022

Abstract
Background: The caries patterns of the first permanent molars (FPMs) among schoolchildren had not been adequately evaluated, and researchers paid no attention to the distributions of fully-erupted FPMs number and proportion in Shenzhen children.
Objective: To quantitatively assess the eruption stages and dental caries patterns of the FPMs for the total students as well as the subgroups.
Methods: A 3-year school-based epidemiological investigation was undertaken by dentists to examine the eruption stages and dental caries patterns of the FPMs, involved the second-grade students from 132 primary schools in Baoan District of Shenzhen, China.
Results: Among 95809 schoolchildren aged 6–8 years, 86.51% individuals had fully erupted the Tooth #16, 87.15% for #26, 89.30% for #36, and 88.81% for #46 (c2=475.033, P<0.001); 80.65% children had all 4 erupted FPMs, with a higher rate among girls than boys (83.37% vs 78.43%; P<0.001). The prevalence of FPMs caries among all students was 13.58% for Tooth #16, 13.53% for #26, 21.02% for #36, and 21.13% for #46 (c2=3322.810, P<0.001). The overall prevalence of dental caries on the FPMs was 28.58%, with a higher prevalence among girls than boys (31.97% vs 25.68%; P<0.001). With increasing age, the FPMs caries prevalence increased (24.89% for 6 years-old, 28.70% for 7 years-oldχχ, and 34.65% for 8 years-old). Mean Decayed-Missing-Filled-Teeth score on FPMs was 0.652, with a decayed component of 0.646 (99.08%) and a filled component of 0.006.
Conclusions: Most schoolchildren aged 6–8 years have fully erupted the FPMs, with a relatively high prevalence of FPMs caries in Shenzhen.
Designing a role for TAs in L2 Literature Circles
Authors: Sevigny Paul 
Published: October 2022

Abstract
Literature Circles (book clubs in school settings) have mainly been studied in first language (L1) contexts. In foreign language contexts, like L1 contexts, published research on best practices recommends the teacher to act as a classroom facilitator instead of joining the circle. The purpose of this study is to examine this claim and practice, particularly with second language learners at the intermediate level. In some situations, it is desirable for Teaching Assistants and teachers to join the circle to provide instruction and feedback. This article addresses the question ‘Should TAs or teachers join the circle and if so, under what conditions?’ This case study follows a new TA in an intermediate EFL class who was asked to join one reading group for the duration of the semester and perform standard roles as a participant. Mixed methods, including quantitative and qualitative discourse analysis, surveys, and interviews, were used in an exploratory, stepwise fashion to elucidate the factors that influence why and how TAs should participate in Literature Circles. Underpinned by Community of Practice theory, findings show that adopting the role of an Unprepared Contributor is the best starting point for training TAs and new teachers to mentor learners. The findings suggest an expansion of contexts for the practice of second or foreign language literature circles (L2-LCs).
Does short-term antipsychotic discontinuation worsen symptoms in acute schizophrenia? A pooled analysis of placebo washout data
Authors: Takeuchi Hiroyoshi , Watabe Kei 
Published: October 2022

Abstract
This study aimed to examine symptom changes during short-term discontinuation of antipsychotics and address whether antipsychotic withdrawal can induce a rapid symptom exacerbation (i.e., rebound psychosis). The data from three double-blind, randomized, controlled trials comparing lurasidone versus placebo in patients with acute exacerbation of schizophrenia were pooled and analyzed. Symptom severity was assessed using the Positive and Negative Syndrome Scale (PANSS) total and the Clinical Global Impression–Severity scale (CGI-S) scores. The scores before and after the antipsychotic discontinuation phase were compared. Factors associated with score changes were also explored. Among 2,154 patients participating in the trials, 600 who received antipsychotic monotherapy and completed the antipsychotic discontinuation phase were included in the analysis. No patients received clozapine. The mean ± standard deviation of the duration of the discontinuation phase was 5.9 ± 2.5 days. The PANSS total and CGI-S scores statistically significantly changed from 94.0 ± 9.5 to 95.4 ± 10.5 and from 4.9 ± 0.6 to 4.9 ± 0.7, respectively, during this phase; however, the absolute difference was minimal. The score changes were not associated with the type or dose of prior antipsychotics, or the duration or strategy (abrupt versus gradual) of antipsychotic discontinuation. Symptoms did not worsen to a clinically meaningful degree after a short-term discontinuation of non-clozapine antipsychotics in patients with acute exacerbation of schizophrenia, suggesting that the efficacy of antipsychotics persists at least several days after discontinuation. This finding casts doubt on the existence of rebound psychosis.
Tethered cord release in patients after open fetal myelomeningocele closure: Intraoperative neuromonitoring data and patient outcomes
Authors: Flanders Tracy M. , Franco Alier J. , Lincul Kristen L. , Pierce Samuel R. , Oliver Edward R. , Moldenhauer Julie S. , Adzick N. Scott , Heuer Gregory G. 
Published: October 2022

Abstract
Purpose: To better understand the clinical course and impact of tethered cord release surgery on patients who have previously undergone open spinal dysraphism closure in utero.
Methods: This is a single-center retrospective observational study on patients undergoing tethered cord release after having previously had open fetal myelomeningocele (MMC) closure. All patients underwent tethered cord release surgery with a single neurosurgeon. A detailed analysis of the patients’ preoperative presentation, intraoperative neuromonitoring (IONM) data, and postoperative course was performed.
Results: From 2009 to 2021, 51 patients who had previously undergone fetal MMC closure had tethered cord release surgery performed. On both preoperative and postoperative manual motor testing, patients were found to have on average 2 levels better than would be expected from the determined anatomic level from fetal imaging. The electrophysiologic functional level was found on average to be 2.5 levels better than the anatomical fetal level. Postoperative motor levels when tested on average at 4 months were largely unchanged when compared to preoperative levels. Unlike the motor signals, 46 (90%) of patients had unreliable or undetectable lower extremity somatosensory evoked potentials (SSEPs) prior to the tethered cord release.
Conclusion: Tethered cord surgery can be safely performed in patients after open fetal MMC closure without clinical decline in manual motor testing. Patients often have functional nerve roots below the anatomic level. Sensory function appears to be more severely affected in patients leading to a consistent motor-sensory imbalance.
Caudate-anchored cognitive connectivity pursuant to orthostatic hypotension in early Parkinson disease
Authors: Yoo Sang-Won , Ha Seunggyun , Oh Yoon-Sang , Ryu Dong-Woo , Yoo Ji-Yeon , Lee Kwang-Soo , Kim Joong-Seok 
Published: October 2022

Abstract
18F-Florbetaben is a tracer used to evaluate the metabolic activity of and amyloid accumulation in the brain when measured in early- and late-phase, respectively. The metabolism of neural substrates could be viewed as a network and might be an important factor in cognition. Orthostatic hypotension (OH) might play an indirect moderating role in cognition, and its latent influence could modify the inherent cognitive network. This study aimed to identify changes of cognitive connectivity according to orthostatic stress in patients with early Parkinson’s disease (PD). This study included 104 early PD patients who were evaluated with a head-up tilt-test and 18F-Florbetaben positron emission tomography (PET). Cognition was assessed with a comprehensive neuropsychological battery that gauged attention/working memory, language, visuospatial, memory, and executive functions. PET images were analyzed visually for amyloid deposits, and early-phase images were normalized to obtain standardized uptake ratios (SUVRs) of pre-specified subregions relevant to specific cognitive domains. The caudate nucleus was referenced and paired to these pre-specified regions. The correlations between SUVRs of these regions were assessed and stratified according to presence of orthostatic hypotension. Among the patients studied, 22 (21.2%) participants had orthostatic hypotension. Nineteen patients (18.3%) were positive for amyloid-𝛽 accumulation upon visual analysis. Moderate correlations between the caudate and pre-specified subregions were observed (Spearman’s rho, range [0.331–0.545]). Cognition did not differ, but the patterns of correlation were altered when the disease was stratified by presence of orthostatic stress. In conclusion, cognition in early PD responds to hemodynamic stress by adapting its neural connections between regions relevant to cognitive functions.
EPICeA : A comprehensive radiobiological assay using dynamic single cells phenotypic tracking under videomicroscopy
Authors: Paris François , Renaud Lea Isabelle , Ribeiro Tony , Rodriguez Pablo Delgado- , Taupin Manon , Magnin Morgan , Roux Olivier , Pecqueur Claire , Barrutia Arrrate Munoz- , Renaud Christophe 
Published: October 2022

Abstract
Cellular assays modeling tumor radiosensitization or normal tissue radiotoxicity commonly support knowledge in radiobiology. Despite worldwide use, outcomes from those assays remain limited since analyses commonly estimate radiosensitivity for the whole-cell population at a specific time point post-radiation disregarding dynamic mechanistic evaluation at single-cell granularity. This manuscript presents EPICeA, a novel integrated radiobiological tool using videomicroscopy to investigate the dynamic radiobiological response of irradiated tumor cells at both single-cell and whole population levels. Manual tracking of U251 glioblastoma cells was directly performed from movies for five consecutive days after exposure up to 15Gy. Observables (cell number, division, abnormal mitosis, and death) were directly extracted from videos and incorporated into dedicated in-house computational algorithms to evaluate radiobiological cell response. First, cladograms illustrating radiation-induced behaviors of each irradiated mother cell and their related out-springs were set up. Then, the population means and single-cell distributions for different radiobiological parameters were computed and analyzed as a function of time and dose. Finally, Pearson correlation coefficients for those 55 features derived from those observables and relevant in radiobiology were established, showing singular correlations. By proposing EPICeA, we strength the characterization of radiobiological response allowing a more accurate evaluation of cell radiosensitivity during dose escalation.
The Maximal Distance of Detectable Isotropic Signals – Solving Fermis Paradox with Grimaldi’s Model
Authors: Platt Karl-Florian 
Published: October 2022

Abstract
In 1950, the Italian physicist Enrico Fermi expressed his astonishment with the sentence "Where is Everybody?" that humanity does not receive signals from extraterrestrial civilizations. A solution to this contradiction for isotropic signals, known as Fermi's paradox, is provided by a model by Claudio Grimaldi. In the present work, with the help of a physical model for signal power, the finite range of isotropic signals assumed in Grimaldi's model is specifically calculated. For this purpose, the FAST telescope in Guizhou and a hypothetical satellite network spanning the Earth are regarded as exemplary receiving instruments. In addition, corresponding signal powers are determined for three potentially habitable planets discovered by the Kepler mission and for stars close to the Sun. It turns out that even the FAST telescope cannot receive corresponding signals, but this is theoretically possible with a satellite network, similar to the GPS network. Accordingly, Grimaldi's assumption turns out to be correct, but the maximum range is considerably smaller than Grimaldi assumed.
Reprogramming alanine catabolism to triacylglycerol biosynthesis for carbohydrate hyper-accumulation in microalgae
Authors: Yeh Tze-Jung , Chen Jen-Chih , Chang Jo-Shu , Lee Tse-Min 
Published: October 2022

AbstractBranched-chain amino acids can be catabolized for triacylglycerol (TGA) biosynthesis in microalgae. To identify the role of alanine in nitrogen (N) starvation-induced TGA accumulation, we performed integrative genetic and pharmaceutical manipulation to decipher the regulation of alanine towards TAG and starch biosynthesis in the algaDesmodesmussp. CNW-N. Alanine aminotransferase (ALT) catabolized alanine towards lipid biosynthesis, which was blocked by ALT inhibitors without impact on already accumulated carbohydrate. Acetyl-CoA carboxylase (ACC) inhibitor (clethodim) suppressed lipid accumulation whilst enlarged carbohydrate pool. Microalgae consist of abundant alanine and higher carbohydrate/lipid buildup under N starvation appeared similar responses, but not for those which alanine was not a major amino acid. It shows that alanine catabolism to lipid is restricted to Chlorophyceae species containing plentiful alanine. The ALT-overexpressingDesmodesmuslines driven byChlorella vulgarisN Deficiency Inducible (CvNDI1) promoter promoted lipid accumulation, which was suppressed by clethodim treatment along with a substantial increase of carbohydrates as bioethanol production feedstock. The discovery of ALT as the genetic targets together with pharmaceutical inhibition of ACC facilitates targeted engineering strategies to mediate carbohydrate hyper-accumulation for cost-effective liquid biofuel manufacture in Chlorophyceae microalgae.
Insight into the nature of the noncovalent interactions of furan, pyridine and pyrazine with AtX
Authors: Zhang Xiaoxiao , Wu Junyong , Yan Hua , Chen Hao , Mao Wanxin , Dai Guoliang 
Published: October 2022

Abstract
The σ-hole interaction (type I), counterintuitive σ-hole interaction (type II) and type Ш noncovalent interaction system formed between three heterocyclic compounds (C4H4O, C5H5N and C4H4N2) and AtX (X = F, Cl and Br) have been investigated employing the MP2/aug-cc-pVTZ. For the C5H5N-AtX and C4H4N2-AtX complexes, the calculated interaction energy decreases according to the sequence type I > type II > type Ш. For the C4H4O-AtX complexes, the interaction energy decreases according to the sequence type II > type I > type Ш. For the same AtX, the interaction energy of type I and type Ш complexes decreases according to the sequence C5H5N > C4H4N2 > C4H4O. while for the type II complexes, the interaction energy decreases according to the sequence C4H4O > C5H5N > C4H4N2. SAPT analysis shows that the electrostatic energy are predominantly of the attraction for the typeⅠcomplexes while the type Ⅲ interactions are mainly electrostatic and dispersion energy. For the type Ⅱ complexes, the induction, dispersion and electrostatic term have been playing the same important in the total attractive interaction. NBO analysis have also been employed.
Effect of inulin intervention on metabolic control and methylation of INS and IRS1 genes in patients with type 2 diabetes mellitus
Authors: Ramírez OC Martínez- , Salazar-Piña DA , Cerón-Ramírez X , Rubio-Lightbourn J , Torres-Romero F , Casas-Ávila L , Castro-Hernández C 
Published: October 2022

Abstract
Background and Aims: Currently, treatments are being sought to improve the control of type II diabetes mellitus(T2DM), and agave inulin has been shown to be effective in reducing glucose levels and other metabolic control parameters. These effects on metabolic control may be associated with changes in the epigenetic modulation of genes of the insulin pathway. For the above mentioned the objective is determine the effect of agave inulin in biochemical parameters and metabolic control and observe the correlation with changes in INSand IRS1 genes methylation in T2DM patients.
Methods: This was a longitudinal experimental study with 67 participants from Mexico, who received an intervention of inulin agave (10 g daily) for 2 months.
Results: The parameters evaluated included anthropometric measurements, biochemical analyses, and the methylation levels of the INS and IRS1 genes by MSP-PCR. For the INS, it was methylated in 76.1% of participants before treatment, and it was methylated in 52.2% of participants after the intervention. For the IRS1, a hemimethylated status was present in 22.3% and 19.4% of the participants pre- and postintervention, respectively. We observed that there was a positive correlation between the changes in the methylation levels of the INS and IRS1 genes pre-and postintervention with metabolic control. For the INS, we found a negative and statistically significant correlation with abdominal fat.
Conclusions: The present study demonstrated that intervention with agave inulin correlates with methylation changes of the IRS1 and INS genes and that genes methylation with the metabolic control in T2DM patients.