bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiR‐205‐5p promotes lung cancer progression and is valuable for the diagnosis of lung cancer
Authors: Zhao Yu‐Long , Zhang Jia‐Xiang , Yang Juan‐Juan , Wei Yu‐Bo , Peng Jie‐Fei , Fu Chang‐Jin , Huang Min‐Hua , Wang Rong , Wang Ping‐Yu , Sun Guang‐Bin , Xie Shu‐Yang 
Published: January 2022

AbstractBackgroundMicroRNAs (miRNAs) function as potential diagnostic biomarkers in various cancers. This study aimed to evaluate the roles of miR‐205‐5p in lung cancer progression and diagnosis.Materials and MethodsMiR‐205‐5p was detected by quantitative real‐time PCR. The effect of miR‐205‐5p on cell proliferation and metastasis was estimated by MTT and flow cytometry. The expression of TP53INP1 and related genes was analyzed by immunoblotting. The diagnostic value of miR‐205‐5p was analyzed using receiver operating characteristic (ROC) curve analysis, sensitivity, and specificity.ResultsThe miR‐205‐5p was increased in lung cancer tissues. MiR‐205‐5p mimics were promoted but its inhibitor suppressed cell proliferation and metastasis compared with control treatment in vitro and in vivo. By regulating the 3′ untranslated region, miR‐205‐5p could negatively regulate TP53INP1 expression, which further inhibited the expression of RB1 and P21, but increased that of cyclinD1. Moreover, the serum miR‐205‐5p levels of patients with lung cancer were significantly higher than those of normal controls, and they were correlated with patients' gender, drinking status, and clinical stage. The area under the ROC curve of serum miR‐205‐5p in the diagnosis of non‐small‐cell lung cancer was 0.8250, respectively. The finding supported its possession of high diagnostic efficiency for lung cancer.ConclusionsMiR‐205‐5p promoted lung cancer cell proliferation and metastasis by negatively regulating the novel target TP53INP1, which further affected the expression of P21, RB1, and cyclin D1. Serum miR‐205‐5p is a novel and valuable biomarker for lung cancer diagnosis.
Depression and alcohol use in American Indian adolescents: The influence of family factors
Authors: Schick Melissa R. , Nalven Tessa , Thomas Emmanuel D. , Weiss Nicole H. , Spillane Nichea S. 
Published: January 2022

AbstractBackgroundRates of both depression and alcohol use are disproportionately higher among American Indian (AI) adolescents than adolescents in the general population. The co‐occurrence of depression and alcohol use is common and clinically relevant given their reciprocal negative influences on outcomes. Family factors may be especially relevant because they could have a buffering effect on this relationship due to the importance of kinship and community in AI communities. The current study examines the roles of family warmth and parental monitoring in the association between depressive symptoms and alcohol use in a large, nationally representative sample of AI adolescents.MethodsData were collected from 3498 AI 7th to 12th graders (47.8% female) residing on or near a reservation during the period 2009 to 2013. Participants reported on their depressive symptoms, family factors, and alcohol use.ResultsThere was a small, but statistically significant positive association between depressive symptoms and alcohol use (r = 0.11, p < 0.001). Greater depressive symptoms were associated with significantly less perceived family warmth (β = −0.09, 95% CI [−0.13, −0.06]), which was associated with significantly greater alcohol use (β = −0.39, 95% CI [−0.55, −0.23]). Family warmth significantly accounted for the association between depressive symptoms and alcohol use at high (β = 0.04, SE = 0.02, 95% CI [0.004, 0.09]), but not low, levels of parental monitoring (β = 0.02, SE = 0.02, 95% CI [−0.002, 0.06]).ConclusionsResults of the present study suggest that developing culturally sensitive prevention and treatment approaches focusing on increasing both family warmth and parental monitoring are important to address the co‐occurrence of depression and alcohol misuse among AI adolescents.
Prepartying and incapacitated rape: Is drinking a risk factor or an outcome?
Authors: Jaffe Anna E. , Blayney Jessica A. , Graupensperger Scott , Cooper Rachel , Larimer Mary E. 
Published: January 2022

AbstractBackgroundIncapacitated rape (IR) is common in college and has been linked to heavier post‐assault drinking and consequences, including blackouts. Following IR, college students may adjust their drinking in ways meant to increase perceived safety, such as enhancing situational control over one's drinks through prepartying, which is drinking before going out to a main social event. Although it is possible that prepartying could influence risk related to IR, it is unclear whether or how prepartying and IR are associated.MethodsTo address these gaps, we examined prepartying as both a risk factor and a consequence of IR, including the reasons for prepartying. Across two studies (Study 1 N = 1074; Study 2 N = 1753) of college women and men, we examined associations between IR and prepartying motives, alcohol consumption, and alcohol‐related blackouts.ResultsWithin the cross‐sectional Study 1, negative binomial regressions revealed that having a history of IR was associated with more alcohol consumption and blackouts when prepartying. In a multivariate model, past‐year IR was associated with preparty motives related to interpersonal enhancement, intimate pursuit, and barriers to consumption, but not situational control. Within the prospective Study 2, a path model revealed that preparty drinking was a prospective predictor of IR in the following year, but past‐year IR did not predict subsequent prepartying.ConclusionsFindings revealed a robust link between recent history of IR and prepartying regardless of gender. Prepartying was a prospective risk factor for subsequent IR. Although more research in this area is needed, addressing prepartying in alcohol interventions may contribute to the prevention of negative outcomes, including sexual assault.
Retailer heterogeneity and price transmission
Authors: Lan Hao , Lloyd Tim A. , McCorriston Steve , Morgan Christopher Wyn 
Published: January 2022

AbstractDifferences in price dynamics across retail chains, even for identical products, offer the opportunity to provide new insights into the determinants of price transmission. Specifically, we highlight the role of strategic complementarity and mark‐up elasticities as the factors underpinning price transmission. Using supermarket data on a sample of orange juice and coffee products from the seven largest retail chains in the UK, the results show that ignoring strategic complementarity exerts a positive bias on the estimation of price transmission and hence overstates the importance of input costs in price setting. In contrast to recent research, private label products are found to exhibit consistently lower levels of price transmission (higher mark‐up elasticity) than national brands, likely reflecting the context of competition in UK food retailing. The focus on mark‐up elasticities points to links between the frequency of price adjustment and competition as determinants of price transmission.
Walking Memories: From the Red Zone to the City on the Tenth Anniversary of the Canterbury Earthquakes
Authors: Wardell Susan 
Published: January 2022

SummaryThis piece of creative nonfiction prose explores memory, landscape, and materiality in the “Red Zone” of Christchurch (Ōtautahi), New Zealand—a formerly residential area devastated by an earthquake in 2011 and subsequently turned into a public green space. The writing is informed by my intermittent ethnographic fieldwork in Christchurch—a European settler‐colonial city established on Ngāi Tahu (indigenous Māori) lands—which has spanned ten years. In recent trips, influenced by a phenomenological lens and sensory methodologies, I began to incorporate walking into my research practice. The walk described in this piece took place on the tenth anniversary of the deadly quake. It begins at the earthquake memorial site in the middle of the urban center, then moves from the Otakaro River Corridor in the Eastern suburbs back towards the city. The journey enables thinking about ruins, hauntings, and the tension between official and alternative narratives of progress—acknowledging the material agencies of the more‐than‐human world as part of this. I reflect on the accesses granted by walking, connecting grief and trauma to dis/oriented movement, materiality, and texture; considering the possibilities for people to work on, as well as walk on, these collective landscapes of memory.
Rethinking the Homeless Crisis: Black Spatial Visions for Los Angeles
Authors: Dozier Deshonay 
Published: January 2022

AbstractBy “thinking conjuncturally”, this article urges urban geographers to rethink the site of encampments as a space for cultural intervention in urban planning and development. Drawing on content analysis of archival records, this article provides a case study of Black‐led and supported encampment communities in the 1980s and 1990s in Los Angeles. These encampment communities emerged in a critical moment when Los Angeles became the homeless capital of the nation while the demographics of the homeless became predominantly Black. The article shows the emergence of encampment communities as both a result of rising homelessness and as a necessity for creating life‐fulfilling alternatives. As such, these include sonic critiques, cooperative planning, forming a commons, and a poetic ethnography against the carceral organisation of homelessness. The article shows that to understand homelessness and crisis, geographers must take seriously the site of the encampment as an emerging cultural intervention.
Racial framing of pandemic outcomes has conditional indirect effects on support for COVID‐19 mitigation policies: Examining moral and threat‐based mediating mechanisms
Authors: Franks Andrew , Xiao Y. Jenny , Hesami Farhang 
Published: January 2022

AbstractTwo studies explored the intersection between the COVID‐19 pandemic and the continuing fight for racial justice. The pandemic has exacerbated existing racial inequalities in the United States in terms of public health and economic outcomes, and it is well‐established that individuals higher in racial bias are less likely to support social safety net programs such as those meant to improve public health and reduce poverty. This is particularly true among individuals who perceive racial minorities as overbenefitting from safety net programs. Accordingly, the primary focus of the current studies was to examine whether framing the pandemic in terms of its disproportionate impact on minorities would reduce support for pandemic mitigation policies. In addition, we examine whether such effects were mediated through psychological mechanisms of moral outrage and perceptions of realistic and symbolic threat, and moderated by participants’ racial bias. Participants’ belief in a just world was included as a covariate given its established role in predicting many related social outcomes. Results suggested that racial framing interacts with participants’ racial bias to affect policy support indirectly through multiple mechanisms. Broad implications regarding the relationship between racial bias and public support for a strong social safety net are discussed.
An analysis of the relationships between religious orientation, authoritarianism, cross‐cultural interactions, and political views
Authors: Cuevas Joshua A. , Dawson Bryan L. , Grant Ashley C. 
Published: January 2022

AbstractThis study investigated the connections between religious ideology, authoritarianism, intergroup relations, and political orientation. Building from the psychological literature on religious belief, the current study sought to explore the extent of these relationships using a university sample from the American South. The Diverse Learning Environments survey was administered to undergraduate students, with 2582 responding. Variables of interest were religious belief, authoritarianism, intergroup relation views, diversity‐related actions, and political views. Results suggest that while general religious orientation did not correlate positively with authoritarianism, Christians, specifically those associated with Evangelical groups, displayed greater authoritarianism than non‐believers and reported fewer diversity‐related interactions. While results indicated that more salient religious identity was associated with right‐leaning political beliefs, an unexpected finding was that non‐belief was associated with greater political involvement. These results suggest patterns of ingroup favoritism among conservative Christians which may lead to outgroup derogation and influence voting patterns.
Platelets modulate CD4+ T‐cell function in COVID‐19 through a PD‐L1 dependent mechanism
Authors: Paletta Ana , Di Diego García Facundo , Varese Augusto , Erra Diaz Fernando , García Julián , Cisneros Juan Carlos , Ludueña Guillermina , Mazzitelli Ignacio , Pisarevsky Andrea , Cabrerizo Gonzalo , López Malizia Álvaro , Rodriguez Alejandra G. , Lista Nicolás , Longueira Yesica , Sabatté Juan , Geffner Jorge , Remes Lenicov Federico , Ceballos Ana 
Published: January 2022

SummarySevere COVID‐19 is associated with a systemic inflammatory response and progressive CD4+ T‐cell lymphopenia and dysfunction. We evaluated whether platelets might contribute to CD4+ T‐cell dysfunction in COVID‐19. We observed a high frequency of CD4+ T cell–platelet aggregates in COVID‐19 inpatients that inversely correlated with lymphocyte counts. Platelets from COVID‐19 inpatients but not from healthy donors (HD) inhibited the upregulation of CD25 expression and tumour necrosis factor (TNF)‐α production by CD4+ T cells. In addition, interferon (IFN)‐γ production was increased by platelets from HD but not from COVID‐19 inpatients. A high expression of PD‐L1 was found in platelets from COVID‐19 patients to be inversely correlated with IFN‐γ production by activated CD4+ T cells cocultured with platelets. We also found that a PD‐L1‐blocking antibody significantly restored platelets’ ability to stimulate IFN‐γ production by CD4+ T cells. Our study suggests that platelets might contribute to disease progression in COVID‐19 not only by promoting thrombotic and inflammatory events, but also by affecting CD4+ T cells functionality.
Motherhood and vaccine refusal in the United Kingdom: A new examination of gender, identity and the journey to contemporary non‐vaccination
Authors: Sythes Laura , Bedford Helen 
Published: January 2022

AbstractIntroductionContemporary research into non‐vaccination has highlighted some of the attitudes, beliefs and characteristics of non‐vaccinating parents with recent research also beginning to examine the journey to non‐vaccination. However, the interaction between gender, identity and non‐vaccination is less well understood, as well as the non‐vaccination journey for parents in the United Kingdom.MethodsUsing purposive sampling, we recruited mothers who have rejected some or all of their child's routine vaccinations in the last 5–10 years. Semi‐ structured interviews were conducted by phone in late 2020 and analysed using thematic analysis.ResultsTen mothers were interviewed. They differed in socio‐economic, educational and cultural backgrounds, yet all wanted the same thing: to have happy and healthy children, a goal which they saw as their responsibility and within their control and did not include vaccination. Within this shared parenting priority, identities varied considerably. Most mothers strongly rejected the label or identity of ‘anti‐vaxxer’, preferring alternative terms with less negative social connotations. The decision not to vaccinate was predominantly made by mothers, describing a dynamic where mothers (rather than fathers/partners) were clearly responsible for their children's health, but this largely appeared to be internalized as the mother's role.ConclusionsThe heterogeneity of mother's identities within the non‐vaccination movement and the pressures on mothers to raise children with ‘optimum health’ explored in this study suggest that non‐vaccination is a largely individual choice that requires nuanced and compassionate engagement to understand the root causes behind this decision.
Influence of case definitions on epidemiological estimates of periodontitis prevalence and its associations with smoking and OHRQoL
Authors: Ke Linbei , Nogueira Getulio , Thomson William Murray 
Published: January 2022

AbstractObjectivesTo compare periodontitis prevalence estimates obtained using the new classification system with those generated using other case definitions from the literature, examine the strength of the association between tobacco smoking and periodontitis (and that between periodontitis and its impact on oral‐health‐related quality of life; OHRQoL) using those definitions.MethodsWe conducted a secondary analysis of data from the 2009 New Zealand Oral Health Survey, a cross‐sectional dental examination survey of a representative sample of people aged 18 or over. We identified cases using 10 different periodontitis case definitions and then compared weighted prevalence estimates across those. The associations between smoking and periodontitis, and between periodontitis and short‐form Oral Health Impact Profile (OHIP‐14) scores, were then compared across the various case definitions.ResultsThere was considerable variation in periodontitis prevalence estimates (range 3% to 59%). All definitions (but one) showed a higher prevalence of periodontitis in smokers than in non‐smokers. The new classification stage III definition showed the strongest association, with an adjusted prevalence ratio of 1.99 (95%CI: 1.35, 2.91). All case definitions (but one) had a higher mean OHIP‐14 score among people with periodontitis.ConclusionsPeriodontitis prevalence estimates are greatly influenced by case definition choice. The new classification system may be more accurate than any other used to date, but questions remain about its utility for periodontal epidemiology.
Association between allergic sensitization and intestinal parasite infection in schoolchildren in Gqeberha, South Africa
Authors: Brandt Oliver , Wegenstein Benjamin , Müller Ivan , Smith Danielle , Nqweniso Siphesihle , Adams Larissa , Müller Simon , du Randt Rosa , Pühse Uwe , Gerber Markus , Navarini Alexander A. , Utzinger Jürg , Labhardt Niklaus D. , Schindler Christian , Walter Cheryl 
Published: January 2022

AbstractBackgroundInconsistent data exist regarding the influence of parasitic infection on the prevalence of allergic sensitization and disorders.ObjectiveTo investigate the impact of geohelminth and protozoan infections on sensitization patterns and allergic symptoms of children living in low‐income communities in Gqeberha, South Africa.MethodsIn a cross‐sectional study, 587 schoolchildren aged 8–12 years were recruited in June 2016 and screened for reactivity to common allergens by skin prick tests (SPTs) and for parasitic infections by stool examination. Additionally, questionnaires were completed to record allergic symptoms the children may have experienced.ResultsPositive SPTs were found in 237/587 children (40.4%), and about one‐third of whom were polysensitized. Sensitizations were most frequently detected against the house dust mites (HDM) Dermatophagoides spp. (31.9%) and Blomia tropicalis (21.0%). Infections with geohelminths (Ascaris lumbricoides, Trichuris trichiura) were found in 26.8% and protozoan infections (Giardia intestinalis, Cryptosporidia spp.) in 13.9% of study participants. Mixed logistic regression analyses revealed negative associations between parasite infection and sensitization to Blomia tropicalis (OR: 0.54, 95% CI 0.33–0.89) and to Dermatophagoides spp. (OR 0.65, 95% CI 0.43–0.96), and between protozoan infection and allergic sensitization to any aeroallergen, although these associations were not significant when adjusted for false discovery. Geohelminth infection and intensity of geohelminth infection were both associated with reduced risk of polysensitization (OR 0.41, 95% CI 0.21–0.86), and this association remained significant with adjustment for false discovery. Reported respiratory symptoms were associated with HDM sensitization (ORs from 1.54 to 2.48), but not with parasite infection.Conclusions and clinical relevanceOur data suggest that geohelminth infection and high geohelminth infection intensity are associated with a reduced risk of polysensitization.
Translating the 10 golden rules of reforestation for coral reef restoration
Authors: Quigley Kate M. , Hein Margaux , Suggett David J. 
Published: January 2022

AbstractEfforts are accelerating to protect and restore ecosystems globally. With trillions of dollars in ecosystem services at stake, no clear framework exists for developing or prioritizing approaches to restore coral reefs even as efforts and investment opportunities to do so grow worldwide. Restoration may buy time for climate change mitigation, but it lacks rigorous guidance to meet objectives of scalability and effectiveness. Lessons from restoration of terrestrial ecosystems can and should be rapidly adopted for coral reef restoration. We propose how the 10 golden rules of effective forest restoration can be translated to accelerate efforts to restore coral reefs based on established principles of resilience, management, and local stewardship. We summarize steps to undertake reef restoration as a management strategy in the context of the diverse ecosystem service values that coral reefs provide. Outlining a clear blueprint is timely as more stakeholders seek to undertake restoration as the UN Decade on Ecosystem Restoration begins.
Implications of wildlife trafficking on the health and conservation efforts of an endangered turtle species in Colombia
Authors: Castro Cortés Andrés Alejandro , Brieva Claudia , Witte Carmel 
Published: January 2022

AbstractThe Colombian slider turtle (Trachemys venusta callirostris) is an endangered species, and one of the most common reptiles admitted to wildlife facilities in Colombia due to wildlife trafficking. To identify the most common diseases at admission and identify factors affecting rehabilitation and translocation, we retrospectively reviewed the medical records of 567 individuals admitted to a wildlife facility in Bogotá, Colombia (2005–2009). In total, 70% of turtles had at least one clinical problem identified at admission, with metabolic bone disease (MBD) (40.8%), ulcerative shell disease (USD) (29%), and dysecdysis (23.9%) being the most reported. Only 44% (249/560; 7 turtles with unknown disposition were excluded) were translocated while the remaining 56% (311/560) died. We used a multivariable logistic regression and found that factors significantly associated (p <.05) with successful rehabilitation included life stage and health status at admission. Adult and juvenile turtles were 3.0 and 2.4 times more likely to be successfully rehabilitated for translocation, respectively, than hatchlings. Individuals identified as healthy at admission were 3.3 times more likely to be rehabilitated than individuals with medical problems. Most medical problems diagnosed at admission are the result of inadequate husbandry from private ownership, and this negatively impacts rehabilitation and eventual translocation of individuals back to their natural habitats. We highlight important considerations for wildlife facilities in the conservation efforts of this endangered species.