bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary malignant melanoma of the esophagus: differentiation from esophageal squamous cell carcinoma and leiomyoma using dynamic contrast-enhanced CT findings
Authors: Shi Yan-Jie , Yang Xin , Yan Shuo , Li Xiao-Ting , Wei Yi-Yuan , Zhang Xiao-Yan , Sun Ying-Shi 
Published: June 2022

Abstract
Purpose
This study aimed to summarize the computed tomography (CT) findings of PMME and differentiate it from esophageal SCC and leiomyoma using CT analysis.

Methods
This was a retrospective study including 23 patients with PMME, 69 patients with SCC, and 21 patients with leiomyoma in our hospital. Qualitative CT morphological characteristics of each lesion included the location, tumor range, ulcer, enhanced pattern, and so on. For quantitative CT analysis, thickness, length and area of tumor, size of largest lymph node, number of metastatic lymph node, and CT value of tumor in plain, arterial, and delayed phases were measured. The associated factors for differentiating PMME from SCC and leiomyoma were examined with univariate and multivariate analysis. Receive operating characteristic curve (ROC) was used to determine the performance of CT models in discriminating PMME from SCC and leiomyoma.

Results
The thickness, mean CT value in arterial phase, and range of tumor were the independent factors for diagnosing PMME from SCC. These parameters were used to establish a diagnostic CT model with area under the ROC (AUC) of 0.969, and accuracy of 90.2%. In pathology, interstitial vessels in PMME were more abundant than that of SCC, and the stromal fibrosis was more obvious in SCC. PMME commonly exhibited intraluminal expansively growth pattern and SCC often showed infiltrative pattern. The postcontrast attenuation difference in maximum CT attenuation value between plain and arterial phases was the independent factor for diagnosing PMME from leiomyoma. This parameter was applied to differentiate PMME from leiomyoma with AUC of 0.929 and accuracy of 86.4%.

Conclusion
The qualitative and quantitative CT analysis had excellent performance for differentiating PMME from SCC and esophageal leiomyoma.

Graphical abstract
Effects of deficit irrigation with saline water on yield and grape composition of Vitis vinifera L. cv. Monastrell
Authors: Martínez-Moreno A. , Pérez-Álvarez E. P. , Intrigliolo D. S. , Mirás-Avalos J. M. , López-Urrea R. , Gil-Muñoz R. , Lizama V. , García-Esparza M. J. , Álvarez M. I. , Buesa I. 
Published: June 2022

AbstractWarm and semi-arid climates are characterized by rainfall scarcity, resulting in the frequent use of low-quality water for irrigation. This work was undertaken to study the effects of water stress and saline irrigation on yield and grape composition of Monastrell grapevines grafted onto 1103P rootstock. The experiment was carried out during three consecutive seasons in a commercial vineyard located in Jumilla (SE Spain) with a loamy-sandy soil. Rainfed vines were compared with five watering regimes including a Control, irrigated with standard water, and four treatments that combined two different schedules for irrigation initiation (pre- and post-veraison) with saline water obtained by adding two types of salts (sulphates and chlorides). Vines from treatments with more severe water stress (i.e., rainfed) showed lower yields and vegetative growth. Moreover, the Rainfed treatment clearly modified grape composition when compared with the Control treatment by increasing berry phenolic content. The application of saline water slightly affected vine performance and grape composition regardless of the type of salts added to the irrigation water. Indeed, the watering regime had a greater effect on yield, vegetative growth and grape composition than the use of different saline waters. Our results suggest that, in the mid-term (3 years), and with a vineyard soil with good drainage, the use of saline waters is not detrimental to vine performance, but does not improve grape composition. Further research is required to assess the long-term effects of saline water application, particularly in view of the important accumulation of chlorides and sodium in leaf tissues observed in vines watered with salty water at the last season of this experiment.
Urinary stone composition in Germany: results from 45,783 stone analyses
Authors: Siener Roswitha , Herwig Helena , Rüdy Jakob , Schaefer Reinhold M. , Lossin Philipp , Hesse Albrecht 
Published: June 2022

Abstract
Purpose
Stone composition can provide valuable information for the diagnosis, treatment and recurrence prevention of urolithiasis. The aim of this study was to evaluate the distribution of urinary stone components and the impact of different crystal forms according to gender and age of patients in Germany.

Methods
A total of 45,783 urinary stones submitted from 32,512 men and 13,271 women between January 2007 and December 2020 were analyzed by infrared spectroscopy. Only the first calculus obtained per patient was included in the analysis.

Results
The most common main stone component was calcium oxalate (CaOx) (71.4%), followed by carbonate apatite (CA) (10.2%) and uric acid (UA) (8.3%). Struvite (2.1%), brushite (1.3%), protein (0.5%) and cystine (0.4%) stones were only rarely diagnosed. CaOx (75%) and UA stones (81%) were more frequently obtained from men than women (p < 0.001). Weddellite (COD) and uric acid dihydrate (UAD) were more common in younger ages than whewellite (COM) and anhydrous uric acid (UAA), respectively, in both men and women. The ratios of COM-to-COD and UAA-to-UAD calculi were approximately 4:1 and 8:1, respectively. The peak of stone occurrence was between the ages of 40 and 59 years.

Conclusion
Stone composition is strongly associated with gender and age. The peak incidence of calculi in both women and men was in the most active phase of their working life. The distinction between different crystal forms could provide clues to the activity and mechanisms of lithogenesis. Further research is needed in understanding the causative factors and the process of stone formation.
Impact of a food-based dietary fat exchange model for replacing dietary saturated with unsaturated fatty acids in healthy men on plasma phospholipids fatty acid profiles and dietary patterns
Authors: Sellem Laury , Antoni Rona , Koutsos Athanasios , Ozen Ezgi , Wong Gloria , Ayyad Hasnaa , Weech Michelle , Schulze Matthias B. , Wernitz Andreas , Fielding Barbara A. , Robertson M. Denise , Jackson Kim G. , Griffin Bruce A. , Lovegrove Julie A. 
Published: June 2022

Abstract
Purpose
UK guidelines recommend dietary saturated fatty acids (SFAs) should not exceed 10% total energy (%TE) for cardiovascular disease prevention, with benefits observed when SFAs are replaced with unsaturated fatty acids (UFAs). This study aimed to assess the efficacy of a dietary exchange model using commercially available foods to replace SFAs with UFAs.

Methods
Healthy men (n = 109, age 48, SD 11 year) recruited to the Reading, Imperial, Surrey, Saturated fat Cholesterol Intervention-1 (RISSCI-1) study (ClinicalTrials.Gov n°NCT03270527) followed two sequential 4-week isoenergetic moderate-fat (34%TE) diets: high-SFA (18%TE SFAs, 16%TE UFAs) and low-SFA (10%TE SFAs, 24%TE UFAs). Dietary intakes were assessed using 4-day weighed diet diaries. Nutrient intakes were analysed using paired t-tests, fasting plasma phospholipid fatty acid (PL-FA) profiles and dietary patterns were analysed using orthogonal partial least square discriminant analyses.

Results
Participants exchanged 10.2%TE (SD 4.1) SFAs for 9.7%TE (SD 3.9) UFAs between the high and low-SFA diets, reaching target intakes with minimal effect on other nutrients or energy intakes. Analyses of dietary patterns confirmed successful incorporation of recommended foods from commercially available sources (e.g. dairy products, snacks, oils, and fats), without affecting participants’ overall dietary intakes. Analyses of plasma PL-FAs indicated good compliance to the dietary intervention and foods of varying SFA content.

Conclusions
RISSCI-1 dietary exchange model successfully replaced dietary SFAs with UFAs in free-living healthy men using commercially available foods, and without altering their dietary patterns. Further intervention studies are required to confirm utility and feasibility of such food-based dietary fat replacement models at a population level.
Evolution and dynamics of the open-vent eruption at Arenal volcano (Costa Rica, 1968–2010): what we learned and perspectives
Authors: Mora Mauricio M. , Lesage Philippe , Taylor-Castillo Waldo , Vergniolle Sylvie , Fourel Loïc , Soto Gerardo J. 
Published: June 2022

Abstract
On 29 July 1968, there was a violent reactivation of Arenal volcano. The resulting westward-directed lateral blast eruption left two villages destroyed and 78 people dead. The activity continued as a long-lasting, open-vent eruption that evolved into seven recognisable phases reflecting changes in magma supply, explosive activity and cone evolution, and ended in October 2010. Here, we review this activity, the geophysical approaches applied to understanding it and the open questions resulting from these insights. The eruptive dynamics were characterised by almost constant lava effusion, degassing, strombolian and vulcanian explosions and infrequent pyroclastic density currents. In this study, the total rock dense equivalent volume of lava and tephra erupted is calculated at 757 ± 77 Mm3, while the volume of the lava flow field is 527 ± 58 Mm3. Typical seismic activity included harmonic and spasmodic tremors, long-period events and explosion signals with frequent audible “booms”. The decline of the eruptive activity started in 2000, with a decrease in the number and size of explosive events, a shift from long to short lava flows along with the collapse of lava flow fronts and the subsequent formation of downward-rolling lava block aprons, the frequent growth of dome-like structures on the summit and a gradual decrease in seismic energy. Multiple geological and geophysical studies during this 42-year-long period of open-vent activity at Arenal resulted in many advances in understanding the dynamics of andesitic blocky lava flows, the origin and diversity of pyroclastic density currents and seismic sources, as well as the role of site effects and rough topography in modifying the seismic wavefield. The acoustic measurements presented here include two types of events: typical explosions and small pressure transients. Features of the latter type are not usually observed at volcanoes with intermediate to evolved magma composition. Explosions have different waveforms and larger gas volumes than pressure transients, both types being associated with active and passive degassing, respectively. This body of data, results and knowledge can inform on the type of activity, and associated geophysical signals, of open-vent systems that are active for decades.
Patient-reported cognitive function before and after glioma surgery
Authors: Schei Stine , Solheim Ole , Salvesen Øyvind , Hansen Tor Ivar , Sagberg Lisa Millgård 
Published: June 2022

Abstract

Background
Little is known about the extent to which glioma patients experience subjective changes in cognitive function following surgery. We sought to assess patient-reported cognitive function before and after glioma surgery and explore potential factors associated with cognitive change.

Methods
In a prospective population-based study, patient-reported cognitive function was measured in 182 patients undergoing primary surgery for diffuse glioma (141 high-grade gliomas (HGG) and 41 low-grade gliomas (LGG)) by using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 cognitive function subscale preoperatively and at 1 and 6 months postoperatively. Binomial logistic regression models were used to assess factors possibly associated with patient-reported cognitive changes.

Results
In the HGG group, the mean cognitive function score increased from 70.9 (95% 66.6, 75.2) preoperatively to 85.1 (95% CI 81.2, 89.0) (p < 0.001) and 83.3 (95% CI 79.1, 87.6) (p < 0.001) at 1 and 6 months postoperatively, respectively. In the LGG group, the mean score was 80.9 (95% CI 74.4, 87.4) preoperatively and remained stable at postoperative follow-ups. Females reported lower scores than males. At an individual level, both improvement and deterioration in cognitive scores were frequently seen in LGG and HGG patients after surgery. Preoperative use of corticosteroids and large tumor volume were predictors for cognitive improvement at 1 month postoperatively. No predictors were identified for cognitive improvement at 6 months and worsening at 1 and 6 months.

Conclusion
Many glioma patients experience perioperative subjective changes in cognitive function after surgery. At group level, HGG patients reported improved cognitive function after surgery, while LGG patients reported stable cognitive function. Preoperative use of corticosteroids and large tumor volume were independently associated with postoperative improvement.
Adaptive Quasi-Monte Carlo Finite Element Methods for Parametric Elliptic PDEs
Authors: Longo Marcello 
Published: June 2022

AbstractWe introduce novel adaptive methods to approximate moments of solutions of partial differential Equations (PDEs) with uncertain parametric inputs. A typical problem in Uncertainty Quantification is the approximation of the expected values of quantities of interest of the solution, which requires the efficient numerical approximation of high-dimensional integrals. We perform this task by a class of deterministic quasi-Monte Carlo integration rules derived from Polynomial lattices, that allows to control a-posteriori the integration error without querying the governing PDE and does not incur the curse of dimensionality. Based on an abstract formulation of adaptive finite element methods (AFEM) for deterministic problems, we infer convergence of the combined adaptive algorithms in the parameter and physical space. We propose a selection of examples of PDEs admissible for these algorithms. Finally, we present numerical evidence of convergence for a model diffusion PDE.
Modern imaging in Cushing’s disease
Authors: Bashari W. A. , Gillett D. , MacFarlane J. , Powlson A. S. , Kolias A. G. , Mannion R. , Scoffings D. J. , Mendichovszky I. A. , Jones J. , Cheow H. K. , Koulouri O. , Gurnell M. 
Published: June 2022

AbstractManagement of Cushing’s disease is informed by dedicated imaging of the sella and parasellar regions. Although magnetic resonance imaging (MRI) remains the investigation of choice, a significant proportion (30–50%) of corticotroph tumours are so small as to render MRI indeterminate or negative when using standard clinical sequences. In this context, alternative MR protocols [e.g. 3D gradient (recalled) echo, with acquisition of volumetric data] may allow detection of tumors that have not been previously visualized. The use of hybrid molecular imaging (e.g. 11C-methionine positron emission tomography coregistered with volumetric MRI) has also been proposed as an additional modality for localizing microadenomas.
The Critical Pressure for Bulk Leakage of Non-planar Smooth Surfaces
Authors: Huang De , Yan Xiang , Larsson Roland , Almqvist Andreas 
Published: June 2022

AbstractThe sealing surfaces subjected to the hydrostatic load from the sealed fluid can deform to such an extent that leakage occurs when the sealed fluid pressure is sufficiently high, and this critical pressure that the seal can sustain without leakage is a fundamental aspect of the seal design. This paper presents a new numerical method based on the bisection algorithm and the boundary element method, which can be utilized to capture the critical pressure with high accuracy. The present method is employed to study the relationship between the critical pressure and the non-planar geometry of the sealing surfaces, under a wide range of loading conditions. The results show that the critical pressure can be acquired from the surface’s dry contact state with a dimensionless correction factor.
Extent of intrinsic disorder and NMR chemical shift assignments of the distal N-termini from human TRPV1, TRPV2 and TRPV3 ion channels
Authors: Wiedemann Christoph , Goretzki Benedikt , Merz Zoe N. , Tebbe Frederike , Schmitt Pauline , Hellmich Ute A. 
Published: June 2022

AbstractThe mammalian Transient Receptor Potential Vanilloid (TRPV) channels are a family of six tetrameric ion channels localized at the plasma membrane. The group I members of the family, TRPV1 through TRPV4, are heat-activated and exhibit remarkable polymodality. The distal N-termini of group I TRPV channels contain large intrinsically disordered regions (IDRs), ranging from ~ 75 amino acids (TRPV2) to ~ 150 amino acids (TRPV4), the vast majority of which is invisible in the structural models published so far. These IDRs provide important binding sites for cytosolic partners, and their deletion is detrimental to channel activity and regulation. Recently, we reported the NMR backbone assignments of the distal TRPV4 N-terminus and noticed some discrepancies between the extent of disorder predicted solely based on protein sequence and from experimentally determined chemical shifts. Thus, for an analysis of the extent of disorder in the distal N-termini of all group I TRPV channels, we now report the NMR assignments for the human TRPV1, TRPV2 and TRPV3 IDRs.
Digital biomarkers and sex impacts in Alzheimer’s disease management — potential utility for innovative 3P medicine approach
Authors: Harms Robbert L. , Ferrari Alberto , Meier Irene B. , Martinkova Julie , Santus Enrico , Marino Nicola , Cirillo Davide , Mellino Simona , Catuara Solarz Silvina , Tarnanas Ioannis , Szoeke Cassandra , Hort Jakub , Valencia Alfonso , Ferretti Maria Teresa , Seixas Azizi , Santuccione Chadha Antonella 
Published: June 2022

Abstract
Digital biomarkers are defined as objective, quantifiable physiological and behavioral data that are collected and measured by means of digital devices. Their use has revolutionized clinical research by enabling high-frequency, longitudinal, and sensitive measurements. In the field of neurodegenerative diseases, an example of a digital biomarker-based technology is instrumental activities of daily living (iADL) digital medical application, a predictive biomarker of conversion from mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) to dementia due to AD in individuals aged 55 + . Digital biomarkers show promise to transform clinical practice. Nevertheless, their use may be affected by variables such as demographics, genetics, and phenotype. Among these factors, sex is particularly important in Alzheimer’s, where men and women present with different symptoms and progression patterns that impact diagnosis. In this study, we explore sex differences in Altoida’s digital medical application in a sample of 568 subjects consisting of a clinical dataset (MCI and dementia due to AD) and a healthy population. We found that a biological sex-classifier, built on digital biomarker features captured using Altoida’s application, achieved a 75% ROC-AUC (receiver operating characteristic — area under curve) performance in predicting biological sex in healthy individuals, indicating significant differences in neurocognitive performance signatures between males and females. The performance dropped when we applied this classifier to more advanced stages on the AD continuum, including MCI and dementia, suggesting that sex differences might be disease-stage dependent. Our results indicate that neurocognitive performance signatures built on data from digital biomarker features are different between men and women. These results stress the need to integrate traditional approaches to dementia research with digital biomarker technologies and personalized medicine perspectives to achieve more precise predictive diagnostics, targeted prevention, and customized treatment of cognitive decline.
Techno-optimism: an Analysis, an Evaluation and a Modest Defence
Authors: Danaher John 
Published: June 2022

AbstractWhat is techno-optimism and how can it be defended? Although techno-optimist views are widely espoused and critiqued, there have been few attempts to systematically analyse what it means to be a techno-optimist and how one might defend this view. This paper attempts to address this oversight by providing a comprehensive analysis and evaluation of techno-optimism. It is argued that techno-optimism is a pluralistic stance that comes in weak and strong forms. These vary along a number of key dimensions but each shares the view that technology plays a key role in ensuring that the good prevails over the bad. Whatever its strength, to defend this stance, one must flesh out an argument with four key premises. Each of these premises is highly controversial and can be subjected to a number of critiques. The paper discusses five such critiques in detail (the values critique, the treadmill critique, the sustainability critique, the irrationality critique and the insufficiency critique). The paper also considers possible responses from the techno-optimist. Finally, it is concluded that although strong forms of techno-optimism are not intellectually defensible, a modest, agency-based version of techno-optimism may be defensible.
Why interculturalism does not always translate into action: Insights from teachers in an Australian primary school
Authors: Tualaulelei Eseta , Halse Christine 
Published: June 2022

AbstractFor intercultural education to impact learners and, in turn, wider society, teachers must turn intercultural perspectives into actions in their professional contexts. This article examines why teachers who hold positive intercultural views might not be compelled to teach to these in their classrooms. Focusing specifically on education for culturally diverse learners, this article presents a critical ethnographic study of two teachers working in a multicultural Australian primary school. It analyses the tensions that complicate teachers’ work for intercultural education, and suggests that competent, well-intentioned teachers might be discouraged from responding pedagogically to their students’ cultural or linguistic backgrounds because of perceived constraints in the contemporary neoliberal educational environment. This prompts our recommendation that future research seek ways to open up new conditions of possibility for teachers to act on their perspectives including opportunities for increased cross-cultural engagement and dialogue.