bluuebunny/crossref_metadata_2025_split huggingface dataset:
DDX20 interlinking with SNRPE endows MYC-driven triple-negative breast cancer therapeutic vulnerability in a splicing-independent manner
Authors: Xie Guang-Dong , Jin Xi , Peng Wen-Ting , Yu Ke-Da , Shao Zhi-Ming , Xu Xiao-En 
Published: December 2022

Abstract
Background: Aberrant splicing is a hallmark of cancer. For MYC-driven cancers, such as triple-negative breast cancer, hypersensitivity to spliceosome-targeted therapy is a novel anticancer strategy since it also triggers antitumorimmunity. Of the approximately 200 known spliceosomal genes, core spliceosomes are essential for cancer cell survival, yet the underlying mechanisms remain elusive.
Methods: First, SNPRE representing the core spliceosomal Sm gene was screened using a multiomics database analysis approach. Then, we investigated the effect of SNRPE on the growth of TNBC cells in vitro and in vivo. We identified DDX20 from the interacting partners of SNPRE as a potential molecule involved in spliceosome vulnerability using coimmunoprecipitationtechniques. The mechanism of the SNRPE-DDX20 axis in tumor spliceosome therapeutic vulnerability was determined by various techniques,including RNA-seq, chromatin immunoprecipitation and other technologies.
Results: In our research, SNRPE was upregulated in TNBC and predicted poor prognosis. Downregulation of SNRPE attenuated the vitality of TNBC in vivo and in vitro. We hypothesized and confirmed DDX20 as an important factor in core spliceosome therapeutic vulnerability. In DDX20-knockout TNBC cells, cell survival is no longer dependent onintracellular splicing activity orSNPRE expression. In DDX20/SNRPE double-downregulated cells, growth ability was restored due to MTOR reactivation via a splicing-independent pathway. In SNRPE-knockdown TNBC cells, ETV3 and its corepressor DDX20 function together to block MTOR expression to induce growth suppression. Once SNRPE expression was high, ETV3 bound to the C-terminus of DDX20 was replaced by SNRPE-containing components, whilethe binding affinity of released ETV3 to MTOR was reduced, and eventually, MTOR was expressed sufficiently to promote proliferation.
Conclusions: Our results reveal that DDX20 is an adaptor in the crosstalk between RNA splicing (SnRNP components such as SNRPE) and the MTOR pathway in MYC-driven TNBC. Patients with high DDX20 expression are likely suitable for treatment with spliceosome modulators, leading to double killing effects by cell arrest and antitumorimmunity. Targeting DDX20 may serve as a therapeutic target for MYC-driven cancers.
Experimental Investigation of the Effect of the Shear Wall Position on Earthquake Behavior in Single-storey and 3D Reinforced Concrete Buildings
Authors: Ali Mohammed Kamal , ALTUN Fatih 
Published: December 2022

Abstract
Preventing the damage of reinforced concrete structures starts with the design of carrier systems. In the selection of the carrier systems, it is important to use reinforced concrete shear walls to increase the stiffness and strength of the structure against earthquake forces. The location of the shear walls in the plan is a detail to be considered for the carrier of the building. In this study, the torsion effects and the change between the force-displacement relations of the carrier systems that will occur in the structural system as a result of the change in the position of the shear wall within the reinforced concrete frame under the effect of an earthquake have been experimentally investigated. For this purpose, one-storey, three-dimensional with two openings in both directions and a total of 5 samples were produced, the first sample without shear wall and the other four samples with shear wall at different positions. The samples were manufactured in a scale of 1/2 and the results obtained from the experiments performed in the laboratory under the effect of earthquake load were compared with each other. As a result of the study, the strength envelope, stiffness, energy consumption, torsion development in the structure, crack formation, crest displacement measured by two different methods, stresses in concrete and reinforcement, and unit deformations in the reinforcement of different elements were measured and evaluated comprehensively. Depending on the reinforced concrete shear wall position, significant differences have been observed in the yield load, the amount of top displacement and the structure torsion in the experimental models. In addition to the presence or absence of reinforced concrete shear wall, whether the shear wall position is symmetrical or not and the position of the shear wall within the structure affected the behavior of the building under the influence of lateral forces. In order to obtain an earthquake resistant structure, the use of the reinforced concrete shear walls in the carrier system in a symmetrical and non-irregular way has emerged as an issue that should be considered in design. The location of the reinforced concrete shear wall, which directly affects the building behavior with the results of the experiment, causes the formation of section effects on the elements that are not predicted in the design.
PERMASALAHAN SOSIAL EKONOMI DI KALANGAN AGEING HOUSEHOLD DI DAERAH TERPENCIL
Authors: Fitrianatsany Fitrianatsany , Habib Muhammad Alhada Fuadilah 
Published: December 2022

Abstrak: Kemiskinan dan kesenjangan sosial sampai saat ini masih menjadi permasalahan di Indonesia, tidak terkecuali pada masyarakat berusia lanjut di daerah terpencil. Dalam penelitian ini penulis mengangkat isu mengenai masyarakat lanjut usia yang mengalami ketidakadilan di bidang sosial-ekonomi di daerah terpencil yaitu di Cilincing, Timur Tengah Selatan dan Gorontalo. Teori yang penulis gunakan adalah teori dari Rawls tentang teori kontrak atau sering disebut dengan The Original Position. Selanjutnya penulis juga menggunakan teori pembangunan menurut Meter dan Horn, mereka membagi lima variabel yang mempengaruhi implementasi dari pembangunan sosial yaitu (1) Standar dan sasaran kebijakan (2) Sumber daya (3) Komunikasi antar anggota dan penguatan aktivasi (4) Karakteristik agen pelaksana dan (5) Kondisi Sosial, ekonomi dan politik. Penelitian ini menggunakan pendekatan kualitatif dengan Teknik pengumpulan data studi literatur. Adapun penyebab permasalahan kemiskinan dan keenjangan sosial dikalangan masyarakat berusia lanjut meliputi keterpencilan dan keterbelakangan, keterbatasan kemampuan mengakses berbagai pelayanan sosial dasar karena ketunaan sosial, kecacatan, keterlantaran, keresahan sosial, serta konflik sosial. Permasalahan kesejahteraan sosial-ekonomi sampai saat ini masih diwarnai dengan permasalahan-permasalahan yang sifatnya konvensional dan perlu ditangani secara bersama antara pemerintah, masyarakat, organisasi sosial, dan lembaga swadaya masyarakat.
Kata Kunci: Kesenjangan Sosial, Kemiskinan, Ageing Household, Kesejahteraan

Abstract: Poverty and social inequality are still a problem in Indonesia, including the elderly in remote areas. In this study, the authors raise the issue of elderly people who experience injustice in the socio-economic field in remote areas, namely in Cilincing, South Middle East and Gorontalo. The theory that the writer uses is Rawls's theory of contract theory or often called The Original Position. Furthermore, the authors also use development theory according to Meter and Horn, they divide five variables that influence the implementation of social development, namely (1) Policy standards and objectives (2) Resources (3) Communication between members and strengthening activation (4) Characteristics of implementing agents and (5) Social, economic and political conditions. This research uses a qualitative approach with data collection techniques of literature studies. The causes of the problem of poverty and social inequality among the elderly include remoteness and underdevelopment, limited ability to access various basic social services due to social disability, disability, neglect, social unrest, and social conflict. Socio-economic welfare problems are still characterized by problems that are conventional in nature and need to be handled jointly by the government, the community, social organizations and non-governmental organizations.
Keywords: Social Inequality, Poverty, Aging Household, Welfare
PENGEMBANGAN ECO EDUWISATA KOI DALAM MENINGKATKAN INCOME KELOMPOK WANITA TANI DI KELURAHAN NGLEGOK KABUPATEN BLITAR
Authors: NURCHOLIS AHMAD , IHSAN SYAIKHU , IHSAN SYAIKHU 
Published: December 2022

Abstrak: Potensi pariwisata di Blitar termasuk di desa Nglegok cukup beragam dan potensial untuk dikembangkan. Mulai wisata alam, sejarah, seni dan budaya serta wisata kuliner. Tujuannya meningkatkan perekonomian masyarakat desa. Upaya pengembangan desa-desa wisata di Kabupaten Blitar khususnya di Kelurahan Nglegok, Kecamatan Nglegok adalah untuk pemerataan pembangunan sektor pariwisata agar tidak hanya terfokus di Blitar Selatan (Pantai, kampung coklat dan sekitarnya) yang sudah menjadi trade mark pariwisata Blitar. Untuk itu, pengembangan desa wisata perlu strategi, antara lain inovatif, kreatif menunjukkan identitas dan ciri khas daerah. Penelitian ini menggunakan metode penelitian PAR (Partisipatory Action Research) dengan jenis Eksplanatif. Hasil penelitian adalah Penerapan Eco Eduwisata Koi yang meliputi Perancangan dan Tujuan Eco Eduwisata, Penyediaan Kolam, Penyediaan Pakan, Pembibitan, Pembesaran, dan Pemasaran. Strategi Pengembangan Eco Eduwisata Koi meliputi Budidaya Koi Berbasis Sumber Mata Air â€œSungai Samanâ€, dan Pengembangan Pakan Berbasis Non-Organik, Pengembangan Manajemen Bagi Hasil Melalui Kelompok Wanita Tani â€œKarya Sejahteraâ€, Pengembangan Blended Wisata Eko Eduwisata Koi, dan Pengembangan Masa Depan Eco Eduwisata Koi. Problematika Pengembangan Eco Eduwisata Koi yaitu meliputi dua faktor. Pertama Faktor Internal yaitu Kesadaran dalam Budidaya Koi yang Masih Rendah, Menjadikan Eko Eduwisata Koi sebagai Bisnis Sampingan, dan Kurang Adanya Pengetahuan dalam Budidaya terutama dalam sisi Penanganan Hama Penyakit. Kedua Faktor Eksternal yaitu Penanganan Penyakit pada Koi, Pergantian Musim yang Ekstrem, dan Permainan Harga Tengkulak. Dampak pelaksanaan pemberdayaan terhadap kelompok wanita tani dalam menjalankan eco eduwisata koi meliputi Segi Â ekonomi, Segi sosial, Segi politik, dan Segi pendidikan.Kata Kunci: Pengembangan, Eco Eduwisata Koi, Kelompok Wanita Tani
Exploración de habilidades socioemocionales en jugadores de esports de CDMX, Puebla y Querétaro
Authors: Hernández Estrada Freddy , Mateos Espejel Lourdes 
Published: December 2022

Este trabajo tiene el objetivo de explorar las experiencias de los jóvenes, de 18 a 26 años de Ciudad de México, Puebla y Querétaro en deportes en juegos electrónicos para ha trabajado en la Universidad de Texas A&M por mas de 10 años. Actualmente es el subdirector de la Maestría en nalítica ofrecida por la Facultad de AdministraciónMays. Anteriormente, era representante estudiantil en la ofcina de admisiones de la misma entidad donde se encargaba de reclutar alumnos en todo el estado de Texas. Es estudiante de doctorado en el departamento de estudios hispánicos en Texas A&M y el área de su investigación tiene que ver con la representación latina en los videojuegos. Se enfoca principalmente en como la cultura se presenta en estos medios a través de espacialidad, banda sonora, jugabilidad y narratología. identifcar las habilidades socioemo cionales que se desarrollan a partir de la interacción entre los participantes. Mediante una investigación de alcance exploratorio y tomando como base a la fenomenología y etnog rafía como metodologías seleccionadas, se genera una aproximación a la defnición de las habilidades mencionadas. Los resultados sugieren que las habilidades socioemocionales en los esports surgen por la confanza que los jugadores requieren desarrollar para la continuidad del juego, el establecimiento de obligaciones asumidas por voluntad propia. Se concluye que, dentro y fuera del juego, se conforma un espacio donde el desenvolvimiento psicológico de los participantes se traduce en motivación y la empatía.
Network of Interaction among Enterobacter Species and Klebsiella Pneumonia Clinical Isolates and the Antibiotic Resistance Pattern at Cape Coast
Authors: Asare Kwame Kumi , Mbata Jennifer , Amoah Samuel , Mayeem Peter Bilatam , Bentsi-Enchill Felicity , Opoku Yeboah Kwaku 
Published: December 2022

Introduction:
Urgent surveillance is required to provide the needed information for the containment of multidrug-resistant (MDR) Enterobacteriaceae. The objective was to examine the antibiotic-resistant patterns among the clinically isolated Enterobacter species and Klebsiella pneumonia from the outpatient department of the University of Cape Coast from 2014 to 2020.

Methodology:
The cultured isolates were Gram-stained for morphological and biochemical tests. Antibiotic susceptibility tests for the K. pneumonia and Enterobacter spp were done using the modified Kirby-Bauer diffusion technique. A double-disk synergy antibiotic test using cefotaxime, amoxicillin/clavulanic acid and ceftazidime antibiotic test was used to identify extended-spectrum beta-lactase (ESBL) and MDR among the isolates. The network of interactions between bacteria isolates and resistant types and the pattern of interaction of K. pneumonia (in the resistant-10 group) and Enterobacter spp (resistant-12) and the various antibiotics tested was performed using Cytoscape version 3.8.2 software. The data are presented in percentage and statistical significance between MDR and extensively drug-resistant (XDR) compared with Chi-square test.

Results:
K. pneumonia formed a clustering network with other bacteria isolates around resistant type 10 (resistant-10) and Enterobacter spp around resistant type 12 (resistant-12). The interactions (edges) of bacteria isolates and resistant types (nodes) were unique for Staphylococcus saprophyticus with Proteus mirabilis which exhibited two patterns of interactions (resistant-10 and resistant-12), connecting the two resistant types among the bacteria isolates. The interactive network patterns of Enterobacter spp and the various antibiotics were different from the interaction patterns for K. pneumonia. The K. pneumonia isolates were highly resistant to cefuroxime 2/3 (66.67%) and ampicillin 2/3 (66.67%) in the year 2020. Enterobacter spp on the other hand were highly resistant to tetracycline 16/20 (80.00%) in 2014 and ceftriaxone 5/9 (55.56%), levofloxacin 5/9 (55.56%), ceftazidime 5/9 (55.56%) and gentamycin 5/9 (55.56%) in 2020. Chi-square analysis showed a highly significant difference of χ2 = 11.87, p=0.0006 and χ2 = 7.789, p=0.0053 between MDR and XDR Enterobacter spp isolates in 2014 and 2020, respectively.

Conclusion:
Early detection, constant monitoring and control practices and policies that prevent the misuse or overuse of these antibiotics are required to slow down the rapid development of resistance to Enterobacter spp and K. pneumonia in Cape Coast.
Records Management Practices: A solution in dealing with big data
Authors: Asnawi Nor Sakila , Abd Kadir Irwan Kamaruddin , Ab Rahman Azmi , Mohd Yunus Alwi 
Published: December 2022

Big data in the Internet of Things (IoT) led to various issues and problems. Therefore, this study aims to provide a guideline through Records Management practices.This study is qualitative with the records professional who deals with big data and records management from various fields. Organizations involved in emerging big data will be chosen as respondents. The study intended to develop guidelines from the current Records Management standard, best practices and guidelines in managing big data. This will offer new research and view on the ability of Records Management as a solution in managing big data.
Keywords: Big Data, Records Management, Internet of Things
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by E-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under the responsibility of AMER (Association of Malaysian Environment-Behavior Researchers), ABRA (Association of Behavioral Researchers on Asians), and cE-Bs (Centre for Environment-Behavior Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
Маньчжуро-монгольский социум на страницах региональных научных изданий первой половины ХХ в.
Authors:   East Siberia State University of Technology and Management (40В/1, Klyuchevskaya St., 1670013 Ulan-Ude, Russian Federation), Dudin Pavel N. 
Published: December 2022

Introduction. The article focuses on Manchu-Mongolian society as a historical and cultural community of East Asia which has had significant impacts on destinies and paths of many Eurasian peoples. Having been dramatically influenced by both objective and subjective factors in the early-to-mid 20th century, one part actually lost its identity while the other one preserved and even strengthened it. These and many other aspects have been actively explored by Russian (Soviet) and foreign scientific communities but works authored by our compatriots to have lived and worked in the to be examined region have been largely overlooked. Goals. The study attempts a source analysis of publications that somehow cast light on Manchu-Mongolian society and that were published in scientific centers of the Far East in the early-to-mid 20th century. Materials and methods. The work examines articles and notes from journals once published by the Society of Russian Orientalists, Society for the Study of Manchuria, Russian Law Faculty of Harbin, and non-periodical editions. The research methodology was determined by an interdisciplinary approach with the prevalence of historical tools. The work comprises data collection, thematic monitoring of publications, discourse analysis, a narrative approach, external and internal criticism of sources and their textual analysis, systemic historical and retrospective methods. The conducted research identifies key early 20th-century trends of Mongolian and Manchu studies, delineates the place of Manchu-Mongolian peoples in the population structure of the Qing Empire / Republic of China assigned to the former in those publications, characterizes the degree of awareness about legal traditions and law practices of the region. Conclusions. The publications under study and their authors contributed a lot to the understanding of the mentioned region of East Asia and its native peoples. The paper states that Orientalists at large — and particularly those engaged in historical and political studies — are obliged to revive names of those researchers, travelers, translators and other participants to have joined that grandiose process of exploring the Manchu-Mongolian region in the early-to-mid 20th century, and made (and still do) our stay in this part of Eurasia peaceful, with most complete knowledge about the latter.
KUALITAS PELAYANAN SPA PADA HOTEL DI KAWASAN WISATA NUSA DUA
Authors: Darmawijaya I Gede 
Published: December 2022

Spa industry is a fast growing industry in the world. In Asia itself, it grew more than 100% from the year 2003 up to 2009, while in Indonesia, this industry grew 174%. This fenomenon brought beneficial effect to spa product industry, especially those companies that produce local or traditional spa product. In order to anticipate the needs and wants of spa industry’s customers to spa products, it is very imperative to reveal the quality of spa’s services viewed from the expectation and perception of international and domestic tourists.In relation to that reason, this study is conducted and aims to find out to what degree tourists perception towards the quality of spa’s services meet their expectations on it. This study was conducted purposively at five villas/resorts at tourist resort Nusa Dua, namely; Bali Desa, Kayu Manis Private Villas & Spa, The Laguna Resort & Spa, Melia Bali Villas & Spa Resort, and Inna Putri Bali. There are 224 respondents accidently used as samples. The data was collected by using questionnaire, then it was analysed with important and performance analysis. The findings of this study were the percentage of perception of tourists towards the quality of spa’s services that meets their expectation was 98.4%
Pengaruh Praktek Kerja Nyata dan Sarana Pembelajaran Praktek terhadap Kesiapan Kerja Mahasiswa Jurusan Manajemen Perhotelan Sekolah Perhotelan Bali pada Industri Pariwisata
Authors: Sudiarta I Nyoman 
Published: December 2022

The aims of this research are to find out: (1) the effect of the job training and practical learning facilities simultaneously to working readiness of students (2) The effect of the job training and practical learning facilities partially to working readiness of students (3) the dominant effect between on the job training and practical learning facilities to working readiness of students.The samples of this research are all students of Hotel Management Program at The Bali Hotel School in the academic year 2010/2011. The total number of the samples are 87 students. Out of those 87 students, there are only 84 students return and answer the questionnaires. The data of each variable was analyzed by means of descriptive statistical analysis to find out any trend appearing in each variable and to explore the significant relation between the independent and dependent variable, both simultaneously and partially. The analysis applied for this is partial correlation and multiple regression analysis.The results of quantitative analysis show that: (1) there was significant effect simultaneously between on the job training and practical learning facilities to working readiness of student based on the analysis of F test with SPSS program version 17 found the value of counted F is 90,343 and Sig value is 0,000. (2) There was significant effect partially between on the job training and practical learning facilities to working readiness of students based on the analysis of t test found significant of > 0,05. (3) The variable having dominant effect to working readiness of student is practical learning facilities (X2) which has the beta value of 0,558 while on the job training (X1) has the beta value of 0,292.
THE TOURISM PRACTICES OF THE ASIAN TOURIST IN BALI
Authors: Arun Suwi Arianty A. A. Ayu 
Published: December 2022

As a widespread tourists destination, Bali in 2011 the international tourists arriving in Bali were increasing around 1.437.725 pax. Especially Asian tourists, they are the major tourists who came to Bali between 2007 and 2011. In view of the Asian tourist become increasingly choosing Bali as a tourists destination, this research will concern about Who are the Asian tourists in Bali? What are their activities in Bali, according to their nationalities? Third, Do the Asian tourists who come from different countries doing the same activities? Fourth, Are their motivation, perceptions, representations, and ways to travel are the same according to their origin country? This research will combine both of qualitative and quantitative methods by reason of heighten the result of the research. In addition to enriched the result, in this research also supported by the literatures both printed or online those are in line with the grand theme of the research.