bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed Tomography of the Chest: Basic Principles
Authors: Sarkar Probir Kumar , Alam Md Jahangir 
Published: June 2022

Tomography is a process by which an image layer of the body is produced, while the images of the structures above and below that layer are made invisible by blurring. computed tomography (CT), the most widely used cross-sectional imaging methods used in medicine, forms cross-sectional images by avoiding super-imposition of structures that occurs in conventional chest imaging, with a >10-fold increase in attenuation sensitivity, within a second without need for breath holding. Like X-ray, an imaging contrast is generated as a consequence of differences in attenuation between the adjacent tissues. The higher the attenuation of the X-ray beam, the brighter the tissue on CT images, and vice versa. The only drawback is the potentially harmful radiation that is measured according to the amount of radiation received by the whole body. Simply, the amount of radiation from a chest CT is equivalent to 400 X-rays. Standard CT usually takes the image of the whole lung and compresses thick slices of about 7-10 mm into images and contrast can be given to highlight structures. High resolution (HRCT) has excellent spatial resolution and very useful for assessing the architecture of the lung. It does not involve IV contrast, acquires thin, non-contiguous slices, at 10-15 mm intervals with thin slices of lung tissues at regular intervals. This reduces the radiation dose by up to 90% compared to standard CT. The axial images are most commonly viewed using lung, mediastinal and bone window. The pulmonary window is specially used for the interpretation of lung parenchyma, airways and interstitial tissues but the mediastinal window is for the interpretation of mediastinal structures. CT interpretation needs a structured and logical approach.
DS (Child) H J 2019; 35(1) : 63-69
Neonatal Myocarditis: A Review
Authors: Mamun Mohammad Abdullah Al , Hussain Manzoor 
Published: June 2022

Neonatal myocarditis is a rare and life-threatening disease with clinical symptoms suggesting bacterial sepsis, accompanied by congestive heart failure, cardiogenic shock and arrhythmias. Enteroviruses and adenoviruses are the most frequent pathogens isolated in myocarditis in neonate. Due to extensive myocyte necrosis in the left ventricle, symptoms may mimic myocardial infarction and circulatory collapse. The diagnosis is suggested by an ischaemic electrocardiogram, raised cardiac enzymes and left ventricular dysfunction. These infants are best managed by early recognition of heart failure, avoidance of hypotension and transfer to an ECMO center. No specific antiviral treatment exists for neonatal myocarditis. Even in the presence of sufficient respiratory and circulatory support, the mortality among neonates with viral myocarditis is high. Majority of survivors develop serious cardiac sequelae. Since neonatal myocarditis is a devastating disease and is not often in the differential diagnosis of neonatal collapse, clinicians should keep a high index of suspicion.
DS (Child) H J 2019; 35(1) : 70-73
Synthesis, Characterization and Biological Activities of Schiff's Base Metal Complexes Derived from Hydroxy Trizene and Aromatic Aldehyde
Authors: Shekhawat A. S. , Singh N. P. , Chundawat N. S. 
Published: June 2022

Schiff's bases are one of the important classes of the ligands, which are obtained by the condensation of amine and aromatic aldehyde. The metal complexes of Schiff's bases are widely considered because they show excellent biological activities. Such as antimicrobial, antitumor, antibacterial, and anti-fungal properties. The present studies deal with synthesis and characterization of Schiff's base transition metal complexes synthesized from general formula (ML) M=Co(II) and Cu(II); L = Schiff's base ligand derived from hydroxy trizene and aromatic aldehyde. The Synthesized complexes were characterized by physical and spectral analysis such as FTIR, 1HNMR, and XRD. They were also tested in vitro biological activities. The Schiff base behaves as a bidentate ligand with O and N donors and binds to metal ions via hydroxy group oxygen and azomethane nitrogen. The Schiff's base ligands and Metal complexes' structure was confirmed by modern instrumental techniques viz, FTIR and 1HNMR. The in-vitro antibacterial studies were carried out against S. aureus, E. coli, and P. Aeruginosa and anti-fungal activities C.albicans, A. clavatus. The result shows that the complexes have excellent biological activities.
Effect of Bulk Acoustic Wave in Piezo Driven Nanomechanical Motion
Authors: Roy S. K. , Hiebert W. K. 
Published: June 2022

Piezo actuation of mechanical resonators is widely adapted because of its simplicity and versatility. Piezo-driven atomic force microscopy cantilevers in air or liquid have a substantial drawback in that they produce spurious resonances that conceal the cantilever resonance peak. Bulk acoustic wave propagation via the piezo-shaker and device substrate causes these undesired peaks. Such restrictions of piezo actuation are rarely reported in nanomechanical resonant sensing. Because most NEMS (nanoelectromechanical systems) experiments are carried out at low pressure to achieve a higher quality factor ) and hence increased sensitivity, spurious resonances are frequently overlooked due to their insignificance. However, this piezo-driven issue may affect NEMS responses at higher pressures (lower Q) and must be addressed carefully. This study reveals spurious resonances from high vacuum to the atmosphere while investigating piezo-driven nanoscale doubly clamped beam responses. At all pressures, spurious peaks with a characteristic frequency span independent of air damping exist, and at higher pressures, they squeeze the mechanical peak. Such squeezing provides a larger derived from the driven phase responses by order of magnitude than the mechanical computed from the measured thermal noise spectra. Interestingly, the characteristic frequency span, not air damping, is revealed to dominate driven .
c-Kit negative Gastro Intestinal Stromal Tumour with Subcutaneous tissue and Lymph Node 115 Metastasis
Authors: Matubber Md Mahiuddin , Billah Syed Muhammad Baqui , Paul Subinoy Krishna , Lslam Jahirul , Afroj Roksana 
Published: June 2022

We report a rare case of c-kit negative gastrointestinal stromal tumor with metastasis in left cervical lymph nodes and subcutaneous tissue. The patient presented to us with recurrent neck swelling, perforation of gas containing hollow viscous and multiple subcutaneous swellings. After confirmation of diagnosis we transferred the patient to medical oncologist. Patient expired two months after starting chemotherapy.
Journal of Surgical Sciences (2017) Vol. 21 (2): 115-117
Pneumothorax and pneumoperitoneum caused by penetrating chest injury
Authors: Alam KABM Taiful , Sarker Md Shah Alam , Hasan Md Khaled , Maharjan Prawesh 
Published: June 2022

Pneumothorax and pneumoperitoneum caused by penetrating chest injury are rare. Pneumoperitoneum following trauma usually indicates the presence of a perforated intraabdominal hollow viscous. Other causes of pneumoperitoneum are through the abdominal wall, through the diaphragm, through female genital tract and through retroperitoneum. Here we report an unusual case of pneumothorax and pneumoperitoneum caused by penetrating injury in the posterior aspect of chest in a young male patient of 33 years who presented to us with chest & abdominal pain & breathlessness. The diagnosis was made on clinical & radiological examination. Tube thoracostomy was done followed by laparotomy and repair of diaphragmatic & splenic injury. Post operative recovery was uneventful & the patient was discharged on 9th p.o.d after removal of thoracostomy tube & wound stiches.
Journal of Surgical Sciences (2018) Vol. 22 (1) : 67-69
Arthropod ectoparasites of cattle and goats from three upazilas of Comilla district, Bangladesh
Authors: Mannan I , Akter T , Ahmad S 
Published: June 2022

The prevalence of ectoparasitic arthropods of cattle and goats in Daudkandi, Homna and Titas upazilas of Comilla district were investigated. During this study (December 2013 to November 2014) 299 cattle and 196 goats were examined; and among them 180 and 117 were found to be infested respectively. Seventeen species of ectoparasites (both larvae and adult) were identified and they are Haematopinus quadripertusus, Haematopinus eurysternus, Linognathus vituli, Damalinia bovis, Stomoxys calcitrans, Musca domistica, Tabanus striatus, Diachlorus sp., Armigeres subalbatus, Ctenocephalides felis, Boophilus microplus, Haemaphysalis bispinosa, Haemaphysalis kinneari, Hyalomma anatolicum, Rhipicephalus sanguineus, Dermacentor sp. and Ixodes sp. The highest prevalence of ectoparasitic infestation (69.94%) were found in Titas and the lowest (53.34%) in Homna upazila. The intensity of ectoparasitic infestation was highest in Titas (12.20) and lowest in Homna (5.21) upazila. Cattle in Titas upazila showed highest prevalence (67.53%) and intensity (8.04) and Homna upazila showed lowest prevalence (48.63%) and intensity (5.55). Goats in Titas upazila showed highest prevalence (76.09%) and intensity (8.38), and Daudkandi upazila showed lowest prevalence (49.37%) and goats in Homna showed lowest intensity (4.80). This study quantifies the level of ectoparasitic infestation in cattle and goats which demands immediate control program and needs more intensive epidemiological study for detail identification of the constraints of animal health and production.
Jahangirnagar University J. Biol. Sci. 8(2): 35-45, 2019 (December)
Tree species diversity of the Kaptai National Park in Rangamati district, Bangladesh
Authors: Rahman Md Mukhlesur , Rahman M Mahfuzur , Huda Md Kamrul 
Published: June 2022

The purpose of this study was to estimate the tree biodiversity in the Kaptai National Park. The total area of the Kaptai National Park is about 4,564 ha (11,273.08 acres) under the jurisdiction of Rangamati South Forest Division, Rangamati Hill Tracts district. The study was conducted through extensive survey only on the tree species composition in the Kaptai National Park. During the investigation, a total of 65 tree species belonging to 29 families were recorded from the park. Among the plant families, Mimosaceae possessed the highest number of species (7) followed by Meliaceae (6), Ancardiaceae (5), Moraceae (4), Verbenaceae (4), Combretaceae (4), Myrtaceae (4), Dipterocarpaceae (3), Fabaceae (3), Rubiaceae (2), Bombacaceae (2), Caesalpiniaceae (2), Dilleniaceae (2) and Bignoniaceae (2) respectively. There were 15 families which contained single species. Tree species belonging to the family Mimosaceae was dominated in respect to number of species and their population as well. The findings of the present investigation will contribute in the regeneration of tree species in this degraded forest ecosystem and in the protection, conservation and sustainable management of the Kaptai National Park.
Jahangirnagar University J. Biol. Sci. 8(2): 71-79, 2019 (December)
Central Diabetes Insipidus in a Child due to Histiocytosis X
Authors: Jesmin Habiba , Afroz Shireen , Haque Saenat 
Published: June 2022

Central diabetes insipidus (CDI) occur due to deficiency of vasopressin which is synthesized in supraoptic and paraventricular nuclei of hypothalamus and stored in posterior pituitary. There are many causes of CDI among them histiocytosis X or lymphohistiocytosis (LCH) is a rare cause. Here we are reporting a 2 years old boy with histiocytosis-Xor presented with CDI. The boy presented with polyuria and polydipsia, low urine specific gravity and osmolality with normal blood sugar and osmolality. Positive response to water deprivation test followed by oral DDAVP establish the diagnosis of CDI. X-Ray skull showed osteolytic punched out lesion and T1 weighted MRI of brain showed thickening of pituitary stalk with absence of bright signal of posterior pituitary. Trephine biopsy showed bone marrow was infiltrated by many eosinophil, some macrophage, lymphocyte and plasma cells. On the basis of all these diagnosis was made as CDI due to histiocytosis-X. Due to hypothalamic- pituitary axis infiltration CDI may be the earliest manifestation of LCH, even before it is diagnosed. Therefore, for diagnostic workup of CDI, LCH should be considered.
Northern International Medical College Journal Vol. 11 No. 1 July 2019, Page 432-434
Heart disease and COVID-19
Authors: Das Prabir Kumar , Rahman Fazlur 
Published: June 2022

Background:Many patients with coronavirus disease 2019(COVID-19) have pre-existing heart disease or develop various cardiac complications during the disease. Understanding the relationship between heart disease and COVID-19 is necessary for optimum management of such condition.
Methods: Literature search done by using Google search engines and PubMed.
Results: Heart involvement occurs in approximately 8-12% of all patients. Acute cardiac injury, as evident by a significant cardiac troponin elevation is the commonest abnormality. Myocarditis, type II myocardial infarction, heart failure, arrhythmia are other cardiac menifestations that are less common. Pre-existing heart disease and/or involvement of the heart by COVID-19 carries worse prognosis.
Conclusion: Most of the reports currently available describes cardiac menifestations briefly. Further study may reveal more clearly the various aspects of cardiac menifestations in COVID-19 patients.
University Heart Journal Vol. 17, No. 1, Jan 2021; 60-65
A Comparative In Vitro and In Vivo Study of Osteogenicity by Using Two Biomaterials and Two Human Mesenchymal Stem Cell Subtypes
Authors: Fievet L. , Serratrice N. , Brulin B. , Giraudo L. , Véran J. , Degardin N. , Sabatier F. , Féron F. , Layrolle P. 
Published: June 2022

Background: Bone repair induced by stem cells and biomaterials may represent an alternative to autologous bone grafting. Mesenchymal stromal/stem cells (MSCs), easily accessible in every human, are prototypical cells that can be tested, alone or with a biomaterial, for creating new osteoblasts. The aim of this study was to compare the efficiency of two biomaterials—biphasic calcium phosphate (BCP) and bioactive glass (BG)—when loaded with either adult bone marrow mesenchymal stem cells (BMMSCs) or newborn nasal ecto-mesenchymal stem cells (NE-MSCs), the latter being collected for further repair of lip cleft-associated bone loss.Materials and Methods: BMMSCs were collected from two adults and NE-MSCs from two newborn infants. An in vitro study was performed in order to determine the best experimental conditions for adhesion, viability, proliferation and osteoblastic differentiation on BCP or BG granules. Bone-associated morphological changes and gene expression modifications were quantified using histological and molecular techniques. The in vivo study was based on the subcutaneous implantation in nude mice of the biomaterials, loaded or not with one of the two cell types. Eight weeks after, bone formation was assessed using histological and electron microscopy techniques.Results: Both cell types—BMMSC and NE-MSC—display the typical stem cell surface markers—CD73+, CD90+, CD105+, nestin - and exhibit the MSC-associated osteogenic, chondrogenic and adipogenic multipotency. NE-MSCs produce less collagen and alkaline phosphatase than BMMSCs. At the transcript level, NE-MSCs express more abundantly three genes coding for bone sialoprotein, osteocalcin and osteopontin while BMMSCs produce extra copies of RunX2. BMMSCs and NE-MSCs adhere and survive on BCP and BG. In vivo experiments reveal that bone formation is only observed with BMMSCs transplanted on BCP biomaterial.Conclusion: Although belonging to the same superfamily of mesenchymal stem cells, BMMSCs and NE-MSCs exhibit striking differences, in vitro and in vivo. For future clinical applications, the association of BMMSCs with BCP biomaterial seems to be the most promising.
Identification of Heparan Sulfate in Dilated Cardiomyopathy by Integrated Bioinformatics Analysis
Authors: Song Wenyu , Lu Fujian , Ding Zequan , Huang Liqi , Hu Kui , Chen Jinmiao , Wei Lai 
Published: June 2022

ObjectivesHeparan sulfate (HS) forms heparan sulfate proteoglycans (HSPGs), such as syndecans (SDCs) and glypicans (GPCs), to perform biological processes in the mammals. This study aimed to explore the role of HS in dilated cardiomyopathy (DCM).MethodsTwo high throughput RNA sequencing, two microarrays, and one single-cell RNA sequencing dataset of DCM hearts were downloaded from the Gene Expression Omnibus (GEO) database and integrated for bioinformatics analyses. Differential analysis, pathway enrichment, immunocytes infiltration, subtype identification, and single-cell RNA sequencing analysis were used in this study.ResultsThe expression level of most HSPGs was significantly upregulated in DCM and was closely associated with immune activation, cardiac fibrosis, and heart failure. Syndecan2 (SDC2) was highly associated with collagen I and collagen III in cardiac fibroblasts of DCM hearts. HS biosynthetic pathway was activated, while the only enzyme to hydrolyze HS was downregulated. Based on the expression of HSPGs, patients with DCM were classified into three molecular subtypes, i.e., C1, C2, and C3. Cardiac fibrosis and heart failure were more severe in the C1 subtype.ConclusionHeparan sulfate is closely associated with immune activation, cardiac fibrosis, and heart failure in DCM. A novel molecular classification of patients with DCM is established based on HSPGs.
N-Acetylcysteine Protects the Stem Cells of the Apical Papilla
Authors: Countryman Kyle , Chen Yen-Wei , Johnson James D. , Paranjpe Avina 
Published: June 2022

ObjectivePrevious research has demonstrated that stem cells of the apical papilla (SCAP) have a lower differentiation potential and are less resistant to cell death as compared to other stem cells. N-acetyl cysteine (NAC) prevents apoptosis of the dental pulp stem cells (DPSCs) by inducing differentiation of these cells. The use of NAC with SCAP could possibly, enhance their differentiation and resistance to cytotoxicity. Hence, the aim of this study was to determine if NAC could prevent apoptosis of SCAP by promoting proliferation and differentiation of these cells thereby contributing to the success of Regenerative endodontic procedures (REPs).MethodsHuman SCAP were cultured with and without 2-hydroxyethyl methacrylate (HEMA), 20 mM NAC and Dexamethasone (Dex). Proliferation rates were analyzed at days 4 and 7. Flow cytometric analysis was used to analyze the levels of cell death. Differentiation of the cells was analyzed using Real-time PCR and an ALP assay. Data were analyzed using ANOVA with a post-hoc Tukey test.ResultsThe NAC-treated cells had similar cell viability compared with the controls. The cells treated with NAC + HEMA had significantly higher rates of proliferation as compared to the HEMA only treated groups and displayed more cell viability when these groups were compared with flow cytometric analysis. Real-time PCR and the ALP assay demonstrated that the NAC group upregulated ALP, RUNX-2, and DSPP genes.ConclusionThe data demonstrated that NAC protects the SCAP from apoptosis and enhances the proliferation and differentiation potential of these cells suggesting that NAC could be used effectively during REPs.
Flint Type Analysis at Late Acheulian Jaljulia (Israel), and Implications for the Origins of Prepared Core Technologies
Authors: Agam Aviad , Rosenberg-Yefet Tamar , Wilson Lucy , Shemer Maayan , Barkai Ran 
Published: June 2022

Prepared Core Technologies, often considered a hallmark of the Middle Paleolithic Mousterian, have recently been observed, to some extent, in many late Lower Paleolithic Acheulian sites. This may indicate a Lower Paleolithic origin of the Levallois method, although the circumstances leading to its emergence, spread and assimilation are still debated. We aim at contributing towards this intriguing issue by studying patterns of flint procurement and exploitation at Late Acheulian Jaljulia (Israel; ∼500–300 kya). We classified artifacts into flint types, using four samples: a general sample, bifaces, “regular” cores with one/two striking platforms, and prepared cores, divided into proto-Levallois, prepared (general) and discoid cores. A geologic survey located potential flint sources, and a petrographic analysis was used to assign flint types to sources. Our results show that while local Turonian flint of the Bi’na Formation dominates the general sample, selectivity in using specific flint types was observed, including among local materials. While brecciated flint types are especially common among handaxes and discoid cores, among proto-Levallois and prepared cores (general), fine-textured homogenous flint types are more common, suggesting that such flint types are better-suited when improved control over the end-product was desired. Based on our results, and following previous suggestions, we support the hypothesis that prepared core technologies in the Levant did not originate from one single technological trajectory. We support the idea that the production of predetermined blanks was based on knowledge gathered from several technological trajectories, including mainly biface shaping and the production of flakes from regular cores. This novel method was most likely transmitted time and again between individuals, gradually adjusting it to produce improved end-products. We see these conclusions as additional support for the view of prepared core technologies at the Late Acheulian as a demonstration of cumulative culture, and the existence of high-fidelity social learning mechanisms in practice already during the late Lower Paleolithic of the Levant.
Early Thyroid Volume Reduction in Subacute Thyroiditis Can be a Potential Indicator for Hypothyroidism
Authors: Park Ji Yong , Choi Wonsuk , Hong A Ram , Yoon Jee Hee , Kim Hee Kyung , Kang Ho-Cheol 
Published: June 2022

BackgroundThyroid volume has been reported to decrease significantly after episodes of subacute thyroiditis (SAT); however, the relationship between thyroid volume and hypothyroidism remains unclear. This study assessed the association between thyroid volume changes and the hypothyroid phase in patients with SAT, a condition that can progress to persistent hypothyroidism.MethodsThis retrospective study evaluated 37 patients diagnosed with SAT at the Department of Endocrinology and Metabolism of Chonnam National University Hwasun Hospital (CNUHH) between 2016 and 2021. Since we could not determine the clinical characteristics of patients with SAT before their episodes, 120 healthy individuals who underwent thyroid ultrasonography during regular check-ups from 2019 to 2021 at CNUHH were selected for comparison. Subgroup analyses were performed on patients with SAT with and without the hypothyroid phase during their clinical course.ResultsThyroid volume was significantly greater in SAT patients at the first visit than in controls (p&lt;0.05), and it decreased constantly throughout the follow-up period. Subgroup analysis showed that the initial thyroid volumes were similar in patients with SAT with and without the hypothyroid phase. However, SAT patients with the hypothyroid phase had significantly smaller thyroid volumes at the 1 month (p=0.025) and 3 month (p=0.006) follow-up visits. The reduction rate of the thyroid volume was significantly different within the first month (p=0.009).ConclusionA greater reduction in thyroid volume in SAT patients within 1 month of episode had a higher chance of developing a subsequent hypothyroid phase, which can lead to persistent hypothyroidism. Serial thyroid ultrasonography in patients with SAT, especially within the first month, may help in predicting the disease course of SAT.