bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies
Authors: Perrett Hailee R. , Brouwer Philip J. M. , Hurtado Jonathan , Newby Maddy L. , Burger Judith A. , Liu Lin , Bouhuijs Joey H. , Gibson Grace , Messmer Terrence , Schieffelin John S. , Antanasijevic Aleksandar , Boons Geert-Jan , Crispin Max , Sanders Rogier W. , Briney Bryan , Ward Andrew B. 
Published: September 2022

SummaryLassa fever is an acute hemorrhagic fever caused by the zoonotic Lassa virus (LASV). The LASV glycoprotein complex (GPC) mediates viral entry and is the sole target for neutralizing antibodies. Immunogen design is complicated by the metastable nature of recombinant GPCs and the antigenic differences amongst LASV lineages. Despite the sequence diversity of GPC, structures of most lineages are lacking. We present the development and characterization of prefusion-stabilized, trimeric GPCs of LASV lineages II, V, and VI, revealing structural conservation despite sequence diversity. High-resolution structures and biophysical characterization of GPC in complex with GP1-A antibodies reveal their neutralization mechanisms. Finally, we present the isolation and characterization of a novel trimer-preferring neutralizing antibody belonging to the GPC-B competition group with an epitope that spans adjacent protomers and includes the fusion peptide. Our work provides molecular detail information on LASV antigenic diversity and will guide efforts to design pan-LASV vaccines.HighlightsStructural characterization of soluble glycoproteins from four Lassa virus lineages.MAb 12.1F, belonging to the GP1-A cluster, inhibits matriglycan and LAMP-1 binding.GP1-A mAbs show glycan-dependence with 19.7E demonstrating lineage-dependent binding.A novel trimer-preferring NAb S370.7 targets the GPC-B epitope.
Gliding towards an understanding of the origin of flight in bats
Authors: Burtner Abigail E. , Grossnickle David M. , Santana Sharlene E. , Law Chris J. 
Published: September 2022

AbstractBats are the only mammals capable of powered flight and have correspondingly specialized body plans, particularly in their limb morphology. The origin of bat flight is still not fully understood due to an uninformative fossil record but, from the perspective of a functional transition, it is widely hypothesized that bats evolved from gliding ancestors. Here, we test predictions of the gliding-to-flying hypothesis of the origin of bat flight by using phylogenetic comparative methods to model the evolution of forelimb and hindlimb traits on a dataset spanning four extinct bats and 231 extant mammals with diverse locomotor modes. Our results reveal that gliders exhibit adaptive trait optima (1) toward relatively elongate forelimbs that are intermediate between those of bats and non-gliding arborealists, and (2) toward relatively narrower but not longer hindlimbs that are intermediate between those of non-gliders and bats. We propose a hypothetical adaptive landscape based on limb length and width optimal trends derived from our modeling analyses. Our results support a hypothetical evolutionary pathway wherein glider-like postcranial morphology precedes a bat-like morphology adapted to powered-flight, setting a foundation for future developmental, biomechanical, and evolutionary research to test this idea.
Presentation of long COVID and associated risk factors in a mobile health study
Authors: Stewart Callum , Ranjan Yatharth , Conde Pauline , Sun Shaoxiong , Rashid Zulqarnain , Sankesara Heet , Cummins Nicholas , Laiou Petroula , Bai Xi , Dobson Richard J B , Folarin Amos A 
Published: September 2022

AbstractBackgrounThe Covid Collab study was a citizen science mobile health research project set up in June 2020 to monitor COVID-19 symptoms and mental health through questionnaire self-reports and passive wearable device data.MethodsUsing mobile health data, we consider whether a participant is suffering from long COVID in two ways. Firstly, by whether the participant has a persistent change in a physiological signal commencing at a diagnosis of COVID-19 that last for at least twelve weeks. Secondly, by whether a participant has self-reported persistent symptoms for at least twelve weeks. We assess sociodemographic and wearable-based risk factors for the development of long COVID according to the above two categorisations.FindingsPersistent changes to physiological signals measured by commercial fitness wearables, including heart rate, sleep, and activity, are visible following a COVID-19 infection and may help differentiate people who develop long COVID. Anxiety and depression are significantly and persistently affected at a group level following a COVID-19 infection. We found the level of activity undertaken in the year prior to illness was protective against long COVID and that symptoms of depression before and during the acute illness may be a risk factor.InterpretationMobile health and wearable devices may prove to be a useful resource for tracking recovery and presence of long-term sequelae to COVID-19. Mental wellbeing is significantly negatively effected on average for an extended period of time following a COVID-19 infection.
Classification of GBA1 variants in Parkinson’s disease; the GBA1-PD browser
Authors: Parlar Sitki Cem , Grenn Francis P. , Kim Jonggeol Jeffrey , Blauwendraat Cornelis , Gan-Or Ziv 
Published: September 2022

ABSTRACTBackgroundGBA1 variants are among the most common genetic risk factors for Parkinson’s Disease (PD). GBA1 variants can be classified into three categories based on their role in Gaucher’s Disease (GD) or PD: severe, mild, and risk variant (for PD).ObjectivesThis paper aims to generate and share a comprehensive database for GBA1 variants reported in PD to support future research and clinical trials.MethodsWe performed a literature search for all GBA1 variants that have been reported in PD. The data has been standardized and complimented with variant classification, Odds Ratio (OR) if available and other data.ResultsWe found 371 GBA1 variants reported in PD: 22 mild, 84 severe, 3 risk variants, and 262 of unknown status. We created a browser, containing up-to-date information on these variants (https://pdgenetics.shinyapps.io/GBA1Browser/).ConclusionsThe classification and browser presented in this work should inform and support basic, translational, and clinical research on GBA1-PD.
Association of IFNAR2 rs2236757 and OAS3 rs10735079 polymorphisms with susceptibility to COVID-19 infection and severity
Authors: Abdelhafez Mohammad , Nasereddin Abedelmajeed , Shamma Omar Abu , Abed Rajaa , Sinnokrot Raghida , Marof Omar , Heif Tariq , Erekat Zaid , Al-Jawabreh Amer , Ereqat Suheir 
Published: September 2022

AbstractThe clinical course and severity of COVID-19 vary among patients. This study aimed to investigate the association of the interferon receptor (IFNAR2) rs2236757 and oligoadenylate synthetase 3 (OAS3) rs10735079 gene polymorphisms with risk of COVID-19 infection and severity among Palestinian patients. The study was conducted between April and May 2021 on 154 participants that divided into three groups: the control group (RT-PCR-negative, n=52), the community cases group (RT-PCR-positive, n= 70) and the critically ill cases (ICU group; n=32). Genotyping of the studied polymorphisms was conducted by amplicon-based next-generation sequencing.The genotype distribution of the IFNAR2 rs2236757 was significantly different among the study groups (P = 0.001), while no significant differences were observed in the distribution of OAS3 rs10735079 genotypes (P = 0.091). Logistic regression analysis adjusted for possible confounding factors revealed a significant association between the risk allele rs2236757A and critical COVID-19 illness (P < 0.025). Among all patients, the rs2236757GA carriers were more likely to have sore throat (OR, 2.52 (95% CI 1.02-6.24); P = 0.011); the risk allele rs2236757A was associated with dyspnea (OR, 4.70 (95% CI 1.80-12.27); P < 0.001), while the rs10735079A carriers were less prone to develop muscle aches (OR, 0.34 (95% CI 0.13-0.88); P = 0.0248) and sore throat (OR, 0.17 (95% CI 0.05-0.55); P < 0.001). In conclusion, our results revealed that the rs2236757A variant was associated with critical COVID-19 illness and dyspnea, whereas the rs10735079A variant was protective for muscle aches and sore throat.
Revisiting Japan’s stakeholder-based system and foreign ownership: IR managers’ view of foreign shareholders in corporate governance reform in Japanese companies
Authors: Nemoto Kumiko 
Published: September 2022

Purpose
Building on the institutional theory perspective on corporate governance change and based on interviews with investor relations (IR) managers in large Japanese companies, this study aims to examine Japanese IR managers’ perceptions of the influence of foreign shareholders on Japan’s corporate governance reform and stakeholder-based system. The paper examines tensions, conflicts and collaborations among different stakeholders involved in corporate governance changes in Japan, especially in the areas of firm ownership, employment relations and boards of directors. The paper explains why convergence does not happen in some large Japanese companies by investigating Japanese managers’ responses to and perceptions of foreign shareholders in multiple corporate contexts.

Design/methodology/approach
The author conducted in-depth interviews with ten IR managers at large, listed Japanese companies in Kyoto and Tokyo and two managers at foreign investment banks in Tokyo, between 2018 and 2021.

Findings
This paper explores five themes that emerged from my interviews: Chief executive officers’ (CEOs’) mixed perceptions of foreign investors, the effectiveness of CEO compensation and outside directors, managers’ reluctance to accept stock price-driven business strategies, foreign investors’ engagement vs investments in index funds and gender patterns, including the effectiveness of token female outside directors. The Japanese companies the author looked at incorporated foreign shareholders as consultants and adopted a few major shareholder-based customs, such as CEOs communicating with investors, having outside directors, increasing CEO compensation and slimming down unprofitable parts of the business via restructuring and downsizing. Simultaneously, they resisted a few major shareholder-based practices. Foreign shareholders’ pressure revealed tensions and contradictions between the Japanese stakeholder system and shareholder primacy-based customs.

Originality/value
This paper is one of the few qualitative studies that explores Japanese IR managers’ responses to and perceptions of foreign shareholders in corporate governance reform, with a particular focus on ownership, employment relations and board members. This paper provides examples of tension, conflict and cooperation between Japanese managers and foreign investors, as seen through the eyes of Japanese IR managers. Examining changes in Japan’s stakeholder-based system of corporate governance reform enables us to better understand the processes by which, with vigorous pressure from government and foreign shareholders, a non-western country like Japan may adopt shareholder-based customs and how such a change may also lead to institutional changes.
Building back better through feminist entrepreneurship policy
Authors: Orser Barbara 
Published: September 2022

PurposeMost feminists policies are aspirational. Deficiencies include vague terms of what constitutes ‘feminist’ within policy, ambiguous investment criteria, lack of consultation and the use of the binary definition of gender negating gender-diverse people (Tiessen, 2019). The purpose of this study is to identify parameters that characterize feminist entrepreneurship policies and to advance recommendations to operationalize these policies.Design/methodology/approachThe COVID-19 pandemic has unveiled fragilities in the socio-economic gains that women entrepreneurs have achieved. Gender-regression is, in part, the product of entrepreneurship policies that fail to recognize the nature and needs of women entrepreneurs. To inform recovery measures, this article considers two research questions: what are the parameters of feminist entrepreneurship policies? and how can parameters of feminist entrepreneurship policy be operationalized in pandemic recovery measures? To inform the questions, the study draws on the academic literature and thematic analysis of three collective feminist action plans to operationalize ten parameters that characterize feminist entrepreneurship policy.FindingsSupplanting ‘feminist’ for women in the construction of entrepreneurship policies, without specifications of how parameters differ dilutes government's efforts to achieve gender quality and women's economic empowerment. To inform policy, recommendations of three feminist recovery policies clustered under seven themes: importance of addressing root causes of inequality; need to invest in social and economic outcomes; economic security; enhancing access to economic resources; investment in infrastructure; inclusive decision-making; and need for gender disaggregated data to inform policy. Differences in policy priorities between collective feminist recovery plans and the academic literature are reported.Research limitations/implicationsThe parameters of feminist entrepreneurial policy require further interpretation and adaptation in different policy, cultural and geo-political contexts. Scholarly attention might focus on advisory processes that inform feminist policies, such as measures to address gender-regressive impacts of the COVID-19 pandemic. Research is also needed to understand the impacts of feminist policies on the lived experiences of diverse women entrepreneurs. Limitations: The study design did not incorporate viewpoints of policymakers or capture bureaucratic boundary patrolling practices that stymie feminist policies. Thematic analysis was limited to three feminist recovery plans from two countries.Practical implicationsRecommendations to operationalize feminist entrepreneurship policies in the context of pandemic recovery are described.Originality/valueTen parameters of feminist entrepreneurship policy are explored. The conceptual study also advances a framework of feminist entrepreneurship policy and considers boundary conditions for when and how the parameters are applicable.
Effectiveness of online education during the COVID-19 pandemic: a study of Bangladesh
Authors: Saifullah Md. Khaled , Sharmeen Nuzhat , Ahmed Zaima 
Published: September 2022

PurposeThe novel coronavirus (COVID-19) remains a global public health emergency as declared by the World Health Organization (WHO). The COVID-19 impacted educational institutions around the world, and they were shut down to minimize the fatalities and spread of the infection. Educational institutions around the world, including Bangladesh, started to conduct online classes as an alternative to physical classes. Therefore, this study assesses the effectiveness of online classes in terms of information and communications technology (ICT) readiness, online class assessment, online class participation, and convenience and flexibility for the educational institutions of Bangladesh.Design/methodology/approachTo fulfill the objective of the study, data were collected from 817 teachers and students. Additionally, the partial least squares (PLS) regression method was adopted as a quantitative technique.FindingsThe study shows that online class participation, online class assessment, and convenience and flexibility have positive relationships with ICT readiness and the effectiveness of online classes. At the same time, the challenges of online classes have negative relationships with ICT readiness and the effectiveness of online classes.Practical implicationsThe study suggests that the government should ensure stable internet connectivity access across the country so that both students and teachers can participate in online classes effectively. Moreover, educational institutional authorities should extend support to the institutions for developing proper ICT infrastructure.Originality/valueICT infrastructure readiness is the backbone for effective online education; however, before the COVID-19 pandemic, online education was almost non-existent at the educational institutional level in Bangladesh. The country started developing the ICT infrastructure only when online classes were scheduled to start, and the development is still ongoing. Hence, this study used ICT readiness as a mediator factor. Moreover, primary data are used in this study. The findings of the study will help academicians and policymakers to better understand the effectiveness of online classes.
Pro-environmental awareness of university students – assessment through sustainability literacy test
Authors: Aikowe Loveth Daisy , Mazancova Jana 
Published: September 2022

Purpose
This study aims to assess the current knowledge and awareness of environmental and sustainable development of Nigerian students by investigating the influence of their sociodemographics.

Design/methodology/approach
This study adapts the concept of using an assessment model in a bespoke application of Sulitest® and Assessment of Student Knowledge. A total of 650 undergraduate students (in the environment, engineering and agriculture programs) were administered a paper-based questionnaire from June to July 2019.

Findings
This study determined that Nigerian students performed poorly on the sustainability literacy test (SLT). Furthermore, students majoring in agriculture exhibited higher knowledge in the social and overall topics, followed by students majoring in the environmental field. From the study findings, the authors recommend that periodic assessment using SLT measures will help higher education institutions (HEIs) identify targeted sustainability programs for the development of students and educators. Hence, HEIs in Nigeria and elsewhere should use sustainability assessment tools to promote pro-environmental awareness.

Originality/value
The SLT is one of several options to assess sustainability knowledge in HEIs. Several HEIs across the USA and Europe have been known to adopt some SLT assessment techniques to improve environmental literacy among students. However, environmental literacy has global implications; hence, this study contributes to the limited body of literature investigating the level of environmental awareness or literacy among university students from a developing country, focusing on the three main study programs (agriculture, environment and engineering).
Wear failure analysis of ball bearings based on lubricating oil for gas turbine
Authors: Sun Jiasi , Bu Jiali , Yang Jinglai , Hao Yanlong , Lang Hong 
Published: September 2022

Purpose
Ball bearings in gas turbine have played a critical role in supporting heavy radial loads but with higher failure rates and repair costs. Therefore, the purpose of this study is to introduce and study a method for their failure analysis with an actual industrial example to guarantee operation reliability and safety.

Design/methodology/approach
Spectrometric oil analysis was used as an early abnormal wear indicator, based on which emergent in-use oil replacement was carried out to reduce the wear rate. However, with wear deterioration, further wear failure investigation was conducted by LaserNet Fines and ferrography to detect the imminent wear failure. Finally, with the assistance of elemental analysis of the typical wear particles, the root cause and worn components were determined by scanning electronic microscope and energy-dispersive X-ray spectroscopy.

Findings
The results have shown that an extraneous source led to wear failure, which later caused overheat between the outer bearing ring and ball. It is in accordance with visual inspection of the disassembled engine.

Originality/value
This method has specified the occasion under which the suitable measurement can be taken. It can achieve the rapid wear condition assessment allowing for root cause and worn parts identification. In addition, wear rate reduction by change of oil can be efficient for most of the time to avoid premature disassemble, especially with the possibility of contamination. It has provided experience to address similar industry-level practical wear failure analysis problems.
You sneeze, and the markets are paranoid: the fear, uncertainty and distress sentiments impact of the COVID-19 pandemic on the stock–bond correlation
Authors: Banerjee Ameet Kumar 
Published: September 2022

PurposeThis paper investigates the influence of three different sentiment indicators on the time-varying stock–bond correlation of 15 countries during the global crisis period of the coronavirus disease 2019 (COVID-19) pandemic.Design/methodology/approachThe author uses the time-varying correlation estimated using the autoregressive moving average -dynamic conditional correlation - generalised autoregressive conditional heteroskedasticity (ARMA-DCC-GARCH) model to achieve this aim. The impact of investor sentiment on the stock–bond correlation was analysed using the Markov regime-switching regression.FindingsThe study results show that the sentiment indicators of fear, uncertainty and distress have a pronounced negative impact on the stock–bond correlation. They further provide evidence of a strong regime effect on the stock–bond correlation with sentiment indicators.Practical implicationsThe paper has a relevant impact on policymakers and fund managers. First, the policymakers now have more insightful evidence of how the stock and bond markets react during crises. Second, the fund managers need to focus on behavioural variables as they may be driving factors in crisis periods that may impair portfolio management.Originality/valueTo the best of my knowledge, the paper is the first to throw light on the behaviour of the stock–bond correlation for 15 countries during the COVID-19 period.
Was the change in accounting standard favourable to the financial reporting of AirAsia? From IAS 17 Leases to IFRS 16 Leases
Authors: Ooi Sue Chern , Lim Chee Chee 
Published: September 2022

Theoretical basis
This case uses agency theory and decision usefulness approach to justify whether the change in accounting standard from IAS 17 Leases to IFRS 16 Leases favourably or adversely affects AirAsia’s financial reporting.

Research methodology
This case was written based on secondary data contained in industry reports, company annual reports, company websites, news reports and accounting standards. The case has been classroom-tested with undergraduate students taking advanced financial accounting and reporting module.

Case overview/synopsis
AirAsia Group Berhad (AirAsia), a Malaysian multinational low-cost carrier, was required to adopt IFRS 16 Leases (equivalent to MFRS 16 Leases), effective from 1 January 2019. The new standard, superseding IAS 17 Leases, was expected to provide investors and creditors with a richer insight into AirAsia’s leasing transactions and financial situations. In view of AirAsia having a substantial fleet of leased aircraft, the adoption of IFRS 16 Leases would change the way AirAsia had to report its borrowings which could subsequently have an impact on its bottom line. Thus, this case requires students to examine the financial implications of adopting IFRS 16 Leases by AirAsia and to determine whether the change in accounting standard favourably or adversely affects AirAsia’s financial reporting.

Complexity academic level
This case is intended for use in intermediate and advanced financial accounting and reporting modules at the undergraduate level.