bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of anesthesia and analgesia with long-term mortality after hip fracture surgery: an analysis of the Australian and New Zealand hip fracture registry
Authors: Lin D-Yin , Woodman Richard , Oberai Tarandeep , Brown Brigid , Morrison Craig , Kroon Hidde , Jaarsma Ruurd 
Published: September 2022

IntroductionHip fractures are a common frailty injury affecting a vulnerable geriatric population. It is debated if anesthetic and analgesic techniques are associated with altered risk for outcomes in hip fracture patients. This study aimed to determine the association of anesthesia and regional analgesia with all cause 12-month mortality and even longer-term mortality after hip fracture surgery in Australia and New Zealand.MethodsData from the Australian and New Zealand Hip Fracture Registry collected from 2016 to 2018, with a minimum follow-up of 12 months, were reviewed. Anesthesia type and use of regional nerve blocks were investigated. The primary outcome was all cause 12-month mortality.Results12-month mortality was 30.6% (n=5410) in a total of 17,635 patients. There was no difference in 12-month mortality between patients who received spinal or general anesthesia (p=0.238). The administration of a combination of general and spinal anesthesia for surgery to repair the fracture was an independent predictor of higher 12-month mortality (unadjusted complete case HR=1.17 (95% CI 1.04 to 1.31); p<0.001). Nerve blocks performed in both the emergency department (ED) and the operating theater (OT) were associated with reduced long-term mortality (median follow-up 21 months) with an unimputed unadjusted HR=0.86 (95% CI 0.77 to 0.96; p=0.043).ConclusionThere was no difference in the association of 12-month mortality between general and spinal anesthesia in patients undergoing hip fracture surgery. However, there was an association with a higher risk of 12-month mortality in patients who received both general and spinal anesthesia for the same surgery. Patients who received a regional nerve block in both the ED and the OT had a lower association of 12-month and longer-term mortality risk. The reasons for these findings remain unknown and should be the subject of further research investigation.
Petroleum-based and biodegradable microplastics alter tissue structure and fecundity in the eastern mudsnail (Ilyanassa obsoleta)
Authors: Hewins Ben , Gibson Glenys 
Published: September 2022

Microplastics are hazardous to aquatic life. Most experiments focus on the effects of a single type of microbead, while in the environment, organisms are exposed to irregularly shaped fragments belonging to several chemical groups. The effects of biodegradable plastics are unknown. We tested the effects of mixed-source (MS) petroleum-based and biodegradable (polylactic acid, PLA) microplastics on the intertidal eastern mudsnail, Ilyanassa obsoleta (Say, 1822), a benthic grazer. MS plastics were collected from local coastal areas (polystyrene, polyethylene, polypropylene, polyvinyl chloride and polyethylene terephthalate, combined) and were tested at three exposures, including one similar to concentrations found locally (2250 particles/kg sediment). Plastics were milled to be similar in size to the biofilm–sediment mix provided to the snails as food (32.94 µm2 for sediment, 137.99 µm2 for MS, and 31.16 µm2 for PLA). Locally relevant exposures of MS microplastics disrupted digestive gland histology, while extreme exposures additionally increased the number of hemocytes and reduced fecundity. Effects of PLA were similar to those of MS microplastics, at the extreme exposure tested here. These results indicate that both petroleum-based and biodegradable microplastics disrupt the structure of the digestive gland and that environmentally relevant exposures induce “hidden” tissue-level changes that are invisible without specialized techniques.
Antidyslipidemic, Antioxidant, and Anti-inflammatory Effects of Jelly Drink Containing Polyphenol-Rich Roselle Calyces Extract and Passion Fruit Juice with Pulp in Adults with Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Khongrum Jurairat , Yingthongchai Pratoomporn , Boonyapranai Kongsak , Wongtanasarasin Wachira , Donrung Nowwapan , Sukketsiri Wanida , Prachansuwan Aree , Chonpathompikunlert Pennapa 
Published: September 2022

Oxidative stress and inflammation play key roles in the pathophysiology in the pathophysiology of dyslipidemia, which are positive risks that increase atherosclerosis leading to important healthcare problems. Therefore, we aimed to study the antioxidant, anti-inflammatory, and lipid-lowering effects of jelly drink containing polyphenol-rich roselle calyces extract and passion fruit juice with pulp concentrate (RP jelly drink) in comparison to a placebo jelly drink for 8 weeks. Forty-three adults with dyslipidemia were randomly assigned into two groups: the RP jelly drink group and the placebo group. Glucose, total cholesterol (TC) triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), oxidative stress biomarkers, inflammatory parameters, and monocyte chemotactic protein-1 (MCP-1) were measured with fasting blood samples at baseline, 4 weeks and 8 weeks of intervention. Results showed a significant decrease in LDL-C and TG, respectively, after 8 weeks of RP jelly drink consumption (LDL-C:

107.63
±
22.98

m
g
/
d
L

; TG:

109.79
±
38.83

m
g
/
d
L

) compared to baseline measurements (LDL-C:

128.43
±
32.74

m
g
/
d
L

; TG:

132.33
±
75.11

m
g
/
d
L

). These may be possible due to reduced inflammation and improvements in oxidative stress, as demonstrated by the reduction of tumor necrosis factor- (TNF-) α and malondialdehyde (MDA), and the enhancement of glutathione (GSH) after consuming the RP jelly drink for 8 weeks. However, no significant differences of treatment on glucose, total cholesterol, MCP-1, interleukin-6, and interleukin-10 were observed. In conclusion, daily consumption of RP jelly drink for 8 weeks resulted in significant improvement in lipid profiles in subjects with dyslipidemia. However, more research is needed to assess its nutritional and functional potential.
Persistent Child Poverty and Mortality in a Cohort of Children with Cancer in Alabama
Authors: Hoppmann Anna L. , Dai Chen , Daves Marla , Imran Hamayun , Whelan Kimberly , Kenzik Kelly , Bhatia Smita 
Published: September 2022

AbstractBackground:One-fifth of U.S. counties are designated persistent child poverty counties (≥20% of children in poverty since 1980). The association between a persistent child poverty environment and mortality in children with cancer is unknown.Methods:Our cohort includes 2,089 children with cancer (2000–2016) in Alabama. We used multivariable Cox proportional hazards modeling (adjusted for sociodemographics/clinical characteristics) to assess mortality by persistent child poverty designation at 1, 5, and 10 years from diagnosis. Distance to treatment was subsequently explored.Results:Forty-two percent of the cohort lived in a persistent child poverty county; they were more likely to be African American (P &lt; 0.0001), have public/no insurance (P = 0.0009), and live &gt;100 miles to treatment (P &lt; 0.0001). Children in persistent child poverty counties were 30% more likely to die by 5 years [95% confidence interval (CI) = 1.06–1.59; P = 0.012]. Distance (per 20-mile increase) to treatment was associated with a 9% increased mortality risk (P &lt; 0.0001). Children with both exposures (distance &gt;100 miles and persistent child poverty) faced the highest mortality risk at 5 years (HR = 1.80; 95% CI = 1.39–2.33; P &lt; 0.0001). In subanalysis, children exposed to persistent child poverty were at higher risk for cancer-related mortality. However, the risk of health-related mortality did not differ.Conclusions:Among children with cancer from the Deep South, persistent child poverty was a prevalent exposure associated with inferior overall survival. Distance to treatment was independently associated with inferior survival. Children with both exposures had the highest risk of mortality.Impact:Persistent child poverty is associated with inferior survival among children with cancer; mechanisms underlying this disparity warrant investigation.See related commentary by Orjuela-Grimm and Beauchemin, p. 295
Efficacy and Safety of the Anti–PD-L1 mAb Socazolimab for Recurrent or Metastatic Cervical Cancer: a Phase I Dose-Escalation and Expansion Study
Authors: An Jusheng , Tang Jie , Li Benjamin X. , Xiong Huihua , Qiu Hui , Luo Lin , Wang Li , Wang Danbo , Zhou Qi , Xu Qin , Song Honglin , Zhang Yunyan , Zhang Hongping , Li Yujie , Yu Xiaohui , Zhang Jing , Ng Rachel , Zhao Wayne , Wong Michael , Dai Xiangrong , Li Guiling , Wu Lingying 
Published: September 2022

Abstract

Purpose:
This study (ClinicalTrials.gov identifier, NCT03676959) is an open, phase I dose-escalation and expansion study investigating the safety and efficacy of the recombinant, fully human anti–programmed death ligand 1 (PD-L1) mAb socazolimab in patients diagnosed with recurrent or metastatic cervical cancer.

Patients and Methods:
Patients received socazolimab every 2 weeks until disease progression. The study was divided into a dose-escalation phase and a dose-expansion phase. Safety and tolerability were primary endpoints of the dose-escalation phase. The primary endpoints of the dose-expansion phase were safety and the objective response rate (ORR) of the 5 mg/kg dose. Efficacy was assessed by the third-party independent review committee (IRC) using the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1).

Results:
104 patients were successfully enrolled into the study. Twelve patients were included in the dose-escalation phase, with one complete response and two partial responses in the 5 mg/kg treatment group. Ninety-two patients (5 mg/kg) were enrolled in the dose-expansion phase. Fifty-four patients (59.3%) had baseline PD-L1–positive tumor expression (combined positive score ≥1). ORR was 15.4% [95% confidence interval (CI), 8.7%–24.5%]. Median PFS was 4.44 months (95% CI, 2.37–5.75 months), and the median OS was 14.72 months (95% CI, 9.59–NE months). ORR of PD-L1–positive patients was 16.7%, and the ORR of PD-L1–negative patients was 17.9%. No treatment-related deaths occurred.

Conclusions:
Our study demonstrates that socazolimab has durable safety and efficacy for the treatment of recurrent or metastatic cervical cancer and exhibits a safety profile similar to other anti–PD-1/PD-L1 mAbs.
Cognitive level classification on information communication technology skills for blog
Authors: Chootong Chalothon , Charoensuk Jirawan 
Published: September 2022

<span lang="EN-US">Learners can study and update their knowledge continually due to the rapid growth of online content. The Medium blog is a well-known open platform that encourages authors who want to share their experiences to publish content on various topics in multiple languages. Meanwhile, readers can query interesting content by searching for a related topic. However, finding suitable content is still challenging for learners, especially information communication technology (ICT) content in Thai, and needs to be classified into beginner, intermediate, and advanced cognitive levels. Moreover, ICT blog content is usually a mix of Thai language and technical terms in English. To overcome the challenge of content classification, a deep neural network (DNN) classification model was constructed to classify the ICT content from the Medium blog into three levels based on cognition. We examined and compared the classification results with strong baseline models, including logistic regression, multinomial naïve bayes, support vector machine (SVM), and multilayer perceptron (MLP). The experimental results indicate that the proposed DNN model attained the highest accuracy (0.878), precision (0.882), recall (0.878), and F1-score (0.875). </span>
Development and Evaluation of Learning Resource Package in Optics for Grade 10 Science
Authors: Recede Reynald Alfred A. , Gaviola Robert J. , Castro Mark A. , Clemente Shynne Izza F. 
Published: September 2022

Learning complicated topics in Physics is one of the most challenging tasks students experi-ence in the classroom. Physics teachers use supplementary materials and laboratory exercises to help students visualize and imagine what they are studying in order to better understand the topics. These learning aids, however, are sometimes not sufficient. Students would still struggle to learn due to lack of effective teaching materials. Without effective teaching materials, it is impossible to master Physics concepts. The study focused on developing and evaluating a learning resource package in Optics for Grade 10 Science. The results showed that the resource package will provide an effective and alternative method for students to be exposed to the scientific method and to explore and observe what the beauty of physics does in our lives. These are very helpful for teachers when teaching Physics concepts. Furthermore, because the learning resource package is already complete, the teacher may feel more prepared to teach optics classes. It is recommended that teacher-writers create lessons that are similar to those already used in science classrooms which may directly address the needs of students.
The The Liquidity Issues and the Profitability Index of Small-Scale Business Entities in Sorsogon Province, Philippines
Authors: Bongalonta Michael B. , Bongalonta Michelle M. 
Published: September 2022

This research was conducted to determine the liquidity issues and profitability index of small-scale businesses operating in the Second District of Sorsogon Province, Philippines as well as to establish the relationship of these two variables. This study used mixed design. A total of 223 small-scale business owners engaged in trading in the Second District of Sorsogon Province, Philippines were the primary respondents of this research. Vertical analyses and stepwise linear regression analyses were utilized.
This study concludes that small-scale business entities in the Province of Sorsogon are highly liquid and profitable depicting their ability to pay short-term maturing obligation. Limited and unavailability of capitalization, Absence of Credit Policy, High Finance cost for debt financing, Inventory obsolescence, Shortage of resources and Lack of markets of measure and scope are the identified liquidity issues by small-scale business owners. To address the issues, the Use equity financing than debt financing, Strengthen the company’s policy of extending loan, Minimize the purchase of inventory or stocks, financial suffering by staying well-informed of your finances and Hiring Bookkeepers are highly recommended by the respondents.
Impact Assessment of Aqua Silviculture of Milagros and Placer, Masbate
Authors: Velza Jacob Frederick P. , Ibañez Roger Y. , Mahawan Alvin M. 
Published: September 2022

With the alarming poverty incidence among fisherfolks communities, the Department of Agriculture – Bureau of Fisheries and Aquatic Resources (DA-BFAR) embarked a project dubbed as Fisheries, Coastal Resources and Livelihood (FishCORAL) funded by United Nations International Fund for Agricultural Development (UN-IFAD) to address the problem by providing livelihood project to the coastal areas of different regions in the country. To assess the impact of the said project in the Bicol region, Bicol University in collaboration with different State Colleges and Universities in the region conducted a project called impact assessment on different project of the FishCORAL livelihood projects. The aim of the study is to assess the key indicators of the project if the goals of the project was met with the implementation of the livelihood project. The study used convenience sampling in the field surveys and focus group discussions to draw conclusion wherein the respondents are the recipient of the aqua silviculture livelihood project. The study reveals that the beneficiaries is under big household category making them hard to financially sustain the basic needs of the family because there is large percentage of dependent individuals. It was also noted that they do not have their own lot where they built their houses and the source of drinking water is unprotected well. In addition, the livelihood project is not sustainable because of various problems such as no profit from the first production cycle, most of the beneficiaries backed out during the implementation and the association itself is not technically prepared to implement the project to sustainable ends. Conduct of more technical capability training along varied aspects of aqua silviculture shall be caried out. Also, trainings on financial literacy, business management and basic record keeping are very necessary. There is also a need to craft a clearcut guideline and operational protocol to guide the aqua silviculture venture. Maybe, a root cause analysis of the previous production cycle should be carried-out to highlight lessons and undertake corrective measures. The association must be reorganized, reoriented and retooled.
Designing an Immersive Virtual Reality Classroom Exploring Behaviour Support Strategies
Authors: Park Hayden , Cooper Grant , Thong Li Ping 
Published: September 2022

Abstract
In this research the authors explore ClasSimVR, a proof-of-concept immersive virtual reality (ivr) application. This software is designed to support pre-service teachers (psts) implementation of a School-Wide Positive Behaviour Interventions and Supports (swpbis) approach to challenging student behaviours. ClasSimVR offers users the opportunity to engage with immersive hypothetical scenarios, whereby virtual students display challenging behaviours. Users respond to these behaviours with a range of possible actions aligned with a swpbis approach. The authors draw on a research-through-design (rtd) methodology to explore the design process of ClasSimVR. The article investigates the implications of an expert evaluation (n=5) conducted as part of the design process of creating ClasSimVR. More broadly, this research contributes to the discourse surrounding the design and implementation of immersive learning environments in educational contexts.
Whose Responsibility is it Anyway? Pupil Mental Health in a Scottish Secondary School
Authors: McKee Christine , Breslin Mark 
Published: September 2022

Abstract
Under Scotland’s Curriculum for Excellence, the health and wellbeing of school pupils is the ‘Responsibility of All’. Mental health is included in this though the extent to which secondary teachers feel confident to deal with the many and varied issues which their pupils present with is less clear. This pilot study seeks to explore the potential gap between the responsibilities that are assigned to Scottish secondary teachers and the responsibilities that they assume. A questionnaire, interviews and focus group were used to garner the views of a group of secondary teachers. Thematic analysis of the data allowed for an exploration of how the role of the secondary teacher with regard to mental health is perceived by those dealing with pupils on a daily basis. Views varied considerably illustrating that the complexity surrounding these issues should not be underestimated.
Designing an optimal infection prevention service: Part 1
Authors: Burnett Emma , Cooper Tracey , Wares Karen , Wigglesworth Neil , Chiwera Lilian , Settle Chris , Robinson Jude 
Published: September 2022

Background Healthcare-associated infections (HCAIs) pose a significant threat to the health and safety of patients, staff, and visitors. Infection prevention and control (IPC) teams play a crucial role in ensuring that systems and processes are in place to keep everyone safe within the healthcare environment. Aim The aim of this study was to identify components of infection prevention services, priorities, indicators of successes and how they are measured, and facilitators and barriers to success. Methods A survey questionnaire was developed and circulated to infection prevention leaders and managers. Findings/results Seventy IPC leaders/managers completed the survey. Participants were responsible for a range of IPC services within and across healthcare organisations, with significant variations to IPC delivery components. Additionally, a range of budget availability was reported. Several IPC service requirements were considered core work of IPC teams, including providing IPC advice and support, surveillance and audit and education and training. Discussion An optimal IPC service needs to be in place to ensure HCAIs are minimised or prevented. In a post pandemic era, this is more important than ever before. This is also as crucial for the health and wellbeing of those working in IPC, who have endured unprecedented demand for their services during the pandemic.
Black salve: risky escharotic
Authors: Rosario Natalie , Castro Juan F 
Published: September 2022

Introduction Black salve ointments are variable in their composition with no standard formula. Patient's may turn to unregulated products to self-treat their conditions. Products that are accessible without a prescription are not necessarily safe and may pose risk to those who use them, as in this case with the use of black salve ointment. Methods This case report discusses the use of black salve ointment on a nodular neck cyst in a 55-year-old Hispanic male patient. The patient applied the black salve ointment (Two Feathers Healing Ointment®) to the cyst, where the ointment remained in contact with his skin for seven days. He required oral antibiotics and was referred to wound care for follow up. Discussion After close follow up and treatment with antibiotics, the eschar healed and left a concave scar on his neck with no other observed complications. Conclusion Healthcare providers are encouraged to discuss complementary and alternative medicine options with patients as some may lead to dangerous effects. Lay Summary This is a case report about a 55 year old male patient who used an over the counter product called Black Salve to treat a cyst on his neck. He came to his primary care doctor's office for a usual checkup. Just before leaving his appointment, he mentioned a dark discolored area on his neck appeared after applying the black salve ointment. The black salve caused his skin to break down, get infected, and turn black. He was treated with antibiotics and close follow up care. After the wound healed, he was left with a scar on his neck from where the ointment broke down the skin. Since this product is available without a prescription, it is important that consumers know that it is not safe for use and may cause complications. If in doubt, ask a healthcare provider about a products risks before use.
Outcomes of Reverse Total Shoulder Arthroplasty for Proximal Humerus Fracture Using Uncemented Stems, a Single Center Study
Authors: Joseph Elias G , Krichmar Aleksandr , Haider Mohammad Nadir , Duquin Thomas R 
Published: September 2022

Background To evaluate the clinical, functional, radiographic, and survival outcomes in patients undergoing reverse total shoulder arthroplasty (RSA) with uncemented stem fixation for proximal humerus fractures. Materials and Methods This is a retrospective cohort study that evaluated a consecutive series of patients with proximal humerus fractures undergoing RSA. Clinical data, radiographs, and re-operation rates were reviewed in patients selected for uncemented stem fixation. The same parameters were compared to the remainder of the cohort undergoing cemented stem fixation. Results The uncemented group (n = 16, median total follow-up = 108 weeks) and cemented group (n = 12, median total follow-up = 223 weeks, p = 0.110) did not differ statistically in pre-operative demographic, post-operative outcomes or incidence of complications. Two patients (12.5%) in the uncemented group required a reoperation (Week 52 and 180) versus none in the cemented group. Conclusion Uncemented stem fixation in RSA for proximal humerus fractures does not yield worse results than cemented stem fixation in properly selected patients. Prospective non-inferiority trials comparing outcomes are recommended.