bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary inclusion of nitrite-containing frankfurter exacerbates colorectal cancer pathology, alters metabolism and causes gut dybiosis in APCminmice
Authors: Crowe William , Pan Xiaobei , Mackle James , Harris Adam , Hardiman Gary , Elliott Chris T , Green Brian D 
Published: March 2022

AbstractColorectal cancer (CRC) is the second most prevelant malignancy in Europe and diet is an important modifiable risk factor. Processed meat consumption, including meats with preservative salts such as sodium nitrite, have been implicated in CRC pathogenesis. This study investigated how the CRC pathology and metabolic status of adenomatous polyposis coli (APC) multiple intestinal neoplasia(min) mice was perturbed following 8 weeks of pork meat consumption. Dietary inclusions (15%) of either nitrite-free pork, nitrite-free sausage or nitrite-containing sausage (frankfurter) were compared against a parallel control group (100% chow). Comprehensive studies investigated: gastrointestinal tract histology (tumours, aberrant crypt foci (ACF) and mucin deplin foci (MDF), lipid peroxidation (urine and serum), faecal microbiota and serum metabolomics (599 metabolites). After 8 weeks mice consuming the frankfurter diet had 53% more (P=0.014) gastrointestinal tumours than control, although ACF and MDF did not differ. Urine and serum lipid peroxidation markers were 59% (P=0.001) and 108% (P=0.001) higher, respectively in the frankfurter group. Gut dysbiosis was evident in these mice with comparably fewerBacteriodesand moreFirmicutes. Fasting serum levels of trimethylamine N-oxide (TMAO) and numerous triglycerides were elevated. Various serum phosphotidylcholine species were decreased. These results demonstrate that nitrite-containing sausages may exaccerbate the development of CRC pathology in APCMinmice to a greater extent than nitrite-free sausages, and this is associated with greater lipid peroxidation, wide-ranging metabolic alternation and gut dysbiosis.
Prime-boost vaccinations with two serologically distinct chimpanzee adenovirus vectors expressing SARS-CoV-2 spike or nucleocapsid tested in a hamster COVID-19 model
Authors: Hasanpourghadi Mohadeseh , Novikov Mikhail , Ambrose Robert , Chekaoui Arezki , Newman Dakota , Ding Jianyi , Giles-Davis Wynetta , Xiang Zhiquan , Zhou Xiang Yang , Liu Qin , Swagata Kar , Ertl Hildegund CJ 
Published: March 2022

ABSTRACTTwo serologically distinct replication-defective chimpanzee-origin adenovirus (Ad) vectors (AdC) called AdC6 and AdC7 expressing the spike (S) or nucleocapsid (N) proteins of an early SARS-CoV-2 isolate were tested individually or as a mixture in a hamster COVID-19 challenge model. The N protein, which was expressed as a fusion protein within herpes simplex virus glycoprotein D (gD) stimulated antibodies and CD8+ T cells. The S protein expressing AdC (AdC-S) vectors induced antibodies including those with neutralizing activity that in part cross-reacted with viral variants. Hamsters vaccinated with the AdC-S vectors were protected against serious disease and showed accelerated recovery upon SARS-CoV-2 challenge. Protection was enhanced if AdC-S vectors were given together with the AdC vaccines that expressed the gDN fusion protein (AdC-gDN). In contrast hamsters that just received the AdC-gDN vaccines showed only marginal lessening of symptoms compared to control animals. These results indicate that immune response to the N protein that is less variable that the S protein may potentiate and prolong protection achieved by the currently used genetic COVID-19 vaccines.
Entrepreneurial intentions among business students: the mediating role of attitude and the moderating role of university support
Authors: Anjum Temoor , Amoozegar Azadeh , Farrukh Muhammad , Heidler Petra 
Published: March 2022

PurposeThis study aims to examine the potential determinants of entrepreneurial intentions (EIs) among business students. To that end, the study investigates the role of entrepreneurship education (EE) and entrepreneurial passion (EP) (inventing and founding), as well as the mediating role of attitude towards entrepreneurship (ATE) and the moderating role of university support.Design/methodology/approachA close-ended questionnaire measured on a seven-point Likert scale was used to collect data from business students at nine universities in Punjab, Pakistan. The sample size comprises 377 participants who were selected using a stratified random sampling technique. Partial least square structural equation modeling (PLS-SEM) was then applied to assess the study’s model and the postulated hypothesis.FindingsThe findings indicated that (a) every independent variable (IV) directly impacts EI [dependent variable (DV)] except EP for founding (EPF), (b) ATE significantly mediates the relationship between IV and DV (c) perceived university support positively moderates the relationship between ATE and EI.Originality/valueAs an implication to policy, the Government must ensure that students are exposed to business environments and find university support through different paths. Specifically, Pakistan’s Minister of Education and the Higher Education Commission (HEC) may consider designing university programs that lead to more influential EE. The empirical findings may help policymakers develop effective policies for promoting entrepreneurship.
Mitigating risk perception in imbalanced supply chain relationships: roles of contract framing and IT integration
Authors: Wang Yuting , Liu Hefu , Fang Jie 
Published: March 2022

PurposeThis paper aims to investigate that how to mitigate the weaker party's risk perception in imbalanced supply chain relationships by framing contracts according to complexity and recurrence. The level of information technology (IT) integration is considered as the moderator influencing the effectuation of contract framing.Design/methodology/approachThe authors conducted a questionnaire survey with 229 firms involved in imbalanced supply chains. Hierarchical regression analysis was used to test the hypotheses.FindingsThe authors found contractual complexity positively influenced performance and relational risk, while contractual recurrence negatively impacted performance and relational risk. This study further reveals the positive moderating effect of IT integration in influencing contractual complexity on relational risk and performance risk and the negative impact of IT integration in influencing contractual recurrence on relational risk and performance risk.Research limitations/implicationsOverall, this study posits the coordinating role of contracts in reducing the weaker party's risk perception in imbalanced supply chain relationships.Practical implicationsThe authors concluded by illustrating how to customize contracts based on the level of IT integration to maximize their role in reducing risk perception.Originality/valueThis study is embedded in imbalanced supply chain relationship, aiming to solve the problem of high-risk perception held by the weaker party, which is a salient threat to the sustainability of collaboration. Contract framing is proposed as an effective approach for mitigating risk perception, which should be carefully designed based on the level of IT integration of the relationship. The authors found that contractual complexity has a positive influence on performance and relational risk, but contractual recurrence has a negative impact on performance and relational risk. This study further reveals the moderating effect of IT integration on the effectuation of contractual framing.
Impacts of platform design on consumer commitment and online review intention: does use context matter in dual-platform e-commerce?
Authors: Xiao Quan , Siponen Mikko , Zhang Xing , Lu Fucai , Chen Si-hua , Mao Mingsong 
Published: March 2022

PurposeThe purpose of this study is to explore the antecedents of consumers’ online review intention in e-commerce platforms from a unique perspective of consumer commitment and platform design. Meanwhile, for the dual-platform strategy, i.e. providing both the web and mobile platforms simultaneously, which is widely adopted in the industry but lacks theoretical concerns, this study aims to examine the differences that platform design influences consumer commitment, consequently contributing to online review intention, between the web and mobile contexts.Design/methodology/approachA cross-sectional online survey is employed, and a structural equation model-based approach is utilized to analyze the data collected from both the website-preferred consumers (N = 167) and the mobile app-preferred consumers (N = 247).FindingsThe results indicate that instrumental support design factors and socio-emotional support factors positively influence consumer commitment, which further affect online review intention positively. Furthermore, design factors in different use contexts generate different impacts, and consumer commitment generates a greater effect on online review intention in the mobile than in the web context. Empathy is found to be an important motivator of consumer commitment in both contexts.Originality/valueTo the best of the authors’ knowledge, as one of the first attempts to capture the differences in the relationship between platform design on consumer commitment and online review intention in different use contexts within the dual-platform e-commerce, this study provides insights for e-commerce platform managers and designers to promote consumer commitment and online review engagement by prioritizing the platform design.
The relevance of XBRL extensions for stock markets: evidence from cross-listed firms in the US
Authors: Cormier Denis , Teller Pierre , Dufour Dominique 
Published: March 2022

PurposeThe study investigates the relevance for stock markets of voluntary disclosure of eXtensible Business Reporting Language (XBRL) extensions [based on International Financial Reporting Standards (IFRS) or US-GAAP] for an international sample of US cross-listed firms.Design/methodology/approachThe study examines if the disclosure of XBRL extensions by a firm provides relevant information to market participants. Towards that end, this paper investigates whether this type of disclosure affects the level of information asymmetry between insiders and investors and if it is value relevant. This study measures information asymmetry by bid-ask spread and value relevance by stock price or Tobin's Q.FindingsAfter a certain level of disclosure of XBRL extensions, the impact on stock pricing is negative (creates noise on stock markets). Controlling for that phenomenon, both IFRS and US-GAAP XBRL extensions are value relevant. Second, results indicate that XBRL extensions are positively (negatively) related to stock market value for firms that exhibit positive (negative) earnings. This suggests a complementary effect between earnings and XBRL extensions on their relation with stock price or Tobin's Q. Finally, the results also indicate that both IFRS extensions and US-GAAP extensions are associated with lower information asymmetry (i.e. bid-ask spread).Originality/valueTo the best of the authors’ knowledge, this study is the first to investigate the relevance of XBRL extensions under IFRS for US cross-listed firms since the availability of the IFRS taxonomy for foreign private issuers that prepare financial statements under IFRS standards.
Oriented extrapolation of common‐midpoint gathers in the absence of near‐offset data using predictive painting
Authors: Khoshnavaz M. Javad 
Published: March 2022

ABSTRACTSeismic reconstruction of missing traces is an extremely important subject in seismic data processing. It includes both interpolation and extrapolation of sparsely recorded data. Extrapolation is often performed in the absence of near‐offset seismic data recorded through marine acquisition. Several reconstruction methods have been designed to circumvent this sparsity in time–offset, frequency–offset and time–frequency domains. In this research, I propose an oriented extrapolation workflow to reconstruct near‐offset missing traces. The term oriented or velocity‐independent refers to those techniques that are based on the use of local slopes. In the proposed workflow, I use an oriented time‐warping algorithm called predictive painting. This algorithm is suitable to predict two‐way traveltimes between two distinctive points of an event. Seismic events recorded by an off‐end array very rarely contain dips of both signs with respect to their zero‐offset location in common‐midpoint domain. This makes the domain an ideal choice to run the algorithm. The proposed algorithm is demonstrated on synthetic and field data examples. I decimate near‐offset seismic traces and reconstruct them through the algorithm. The reconstruction results are compared with the original data before decimation. Furthermore, insensitivity of the proposed workflow to the presence of class II amplitude‐versus‐offset anomalies is demonstrated on a synthetic example. I also perform a velocity‐dependent (a normal‐moveout‐based) technique on the field data and compare the corresponding outcomes with the results achieved by the application of the proposed velocity‐independent approach. All the results suggest that the proposed technique has the potential to be used in the exploration industry.
Patterns of emergency admission for IBD patients over the last 10 years in Lothian, Scotland: a retrospective prevalent cohort analysis
Authors: Lyons Mathew , Derikx Lauranne A. A. P. , Fulforth James , McCall Sophie , Plevris Nikolas , Jenkinson Philip W. , Kirkwood Kathryn , Siakavellas Spyros , Lucaciu Laura , Constantine‐Cooke Nathan , Arnott Ian D. , Henderson Paul , Russell Richard K. , Wilson David C. , Lees Charlie W. , Jones Gareth‐Rhys 
Published: March 2022

SummaryObjectiveIt is unclear how the compounding prevalence of inflammatory bowel disease (IBD) has translated into the causes and rates of hospitalisation, particularly in an era of increased biologic prescribing. We aimed to analyse these trends in a population‐based IBD cohort over the last 10 years.DesignThe Lothian IBD registry is a complete, validated, prevalent database of IBD patients in NHS Lothian, Scotland. ICD‐10 coding of hospital discharge letters from all IBD patient admissions to secondary care between 1 January 2010 and 31 December 2019 was interrogated for admission cause, with linkage to local/national data sets on death and prescribed drugs.ResultsFifty‐seven per cent (4673/8211) of all IBD patients were admitted to secondary care for >24 h between 1 January 2010 and 31 December 2019. In patients <40 years, IBD was the commonest reason for admission (38% of admissions), whereas infection was the most common cause in those >60 years (19% of admissions). Three per cent (243/8211) of IBD patients accounted for 50% of the total IBD bed‐days over the study period.Age‐standardised IBD admission rates fell from 39.4 to 25.5 admissions per 100,000 population between 2010 and 2019, an average annual percentage reduction of 3% (95% CI −4.5% to −2.1%, p < 0.0001). Non‐IBD admission rates were unchanged overall (145–137 per 100,000 population) and specifically for serious (hospitalisation) and severe (ITU admission or death) infection over the same period.ConclusionDespite compounding prevalence and increased biologic use, IBD admission rates are falling. The cause of admission varies with age, with infection the predominant cause in older patients.
Leonurine alleviates ferroptosis in cisplatin‐induced acute kidney injury by activating the Nrf2 signalling pathway
Authors: Hu Jianqiang , Gu Wenjing , Ma Ning , Fan Xiaoye , Ci Xinxin 
Published: March 2022

Background and purposeEvidence indicates that ferroptosis plays a key role in acute kidney injury induced by cisplatin. The Nrf2/NRF2 pathway regulates oxidative stress, lipid peroxidation and positively regulates cisplatin‐induced acute kidney injury, but its effect along with the alkaloid leonurine, found in motherwort, on ferroptosis after such acute kidney injury remains unclear.Experimental ApproachThe anti‐ferroptotic effects of Nrf2 and leonurine were assessed in a mouse model of cisplatin‐induced acute kidney injury. In vitro, the effects of leonurine on erastin‐ and RSL3‐induced HK‐2 human PTEC ferroptosis were examined.Key ResultsNrf2 deletion induced ferroptosis‐related protein expression and iron accumulation in vivo, aggravating cisplatin‐induced acute kidney injury. Leonurine activated Nrf2 and prevented iron accumulation, lipid peroxidation and ferroptosis in vitro, being abolished in siNrf2‐treated cells. Moreover, leonurine potently inhibited cisplatin‐induced renal damage, as assessed by of serum creatinine, blood urea nitrogen, kidney injury molecule‐1 and NGAL. Importantly, leonurine activated the Nrf2 antioxidative pathway and preventing changes in ferroptosis‐related morphological and biochemical indicators, malondialdehyde level, SOD and GSH depletion, and GPX4 and xCT down‐regulation, in cisplatin‐induced acute kidney injury. Nrf2 KO mice were more susceptible to ferroptosis after cisplatin‐induced acute kidney injury than control mice. The protective effects of leonurine on acute kidney injury and ferroptosis were largely abolished in Nrf2 KO mice.Conclusion and ImplicationsThese data suggest that renal protective effects of Nrf2 activation on cisplatin‐induced acute kidney injury are achieved, at least partially, by inhibiting lipid peroxide‐mediated ferroptosis, highlighting the potential of leonurine in acute kidney injury treatment.
Factors associated with the early emergence of atypical feeding behaviours in infants and young children: A scoping review
Authors: Mudholkar Asmita , Korostenski Larissa , Blackwell Dianne , Lane Alison E. 
Published: March 2022

AbstractBackgroundAtypical feeding behaviours such as significantly limited food preferences, hypersensitivity to food textures or temperatures and pocketing food without swallowing are common concerns in child health. Current reports indicate an inter‐relationship between early growth, feeding problems and developmental disorders, yet little is known about how these behaviours develop in early childhood. There is also a lack of consensus about clinical definitions for atypical feeding behaviours, diagnostic thresholds and the associated precursors. To date, there has been no synthesis of the extant literature about factors associated with the early onset of atypical feeding behaviours in young children.ObjectiveThis scoping review aimed to characterize the factors associated with the early emergence of atypical feeding behaviours in typically developing young children.MethodsCINAHL, MEDLINE, PsycINFO and Scopus databases were searched. Studies published in the last 5 years were included if they examined factors associated with the development of atypical eating behaviours in infants and young children. Of the 2137 records obtained after the search strategy was applied, 202 full‐text articles were retrieved for a more detailed examination and to ensure they met the inclusion criteria. This resulted in 54 studies being included in this scoping review.ResultsOf the 54 studies, three studies analysed precursors responsible for atypical feeding behaviours, and 51 studies discussed the factors associated with the early emergence of feeding difficulties. Multiple factors, including genetic factors, breastfeeding, late introduction of solids and lumpy foods, complementary feeding techniques, parental mental health, prematurity and child factors including temperament, were identified. There is inconsistent evidence for the associations between breastfeeding exposure and feeding difficulties.ConclusionsThis study identified multiple factors potentially associated with the early onset of atypical feeding behaviours in young children; however, there is insufficient evidence at this time to support specific recommendations for early feeding practices in young children. More methodologically rigorous studies are needed to extend these findings.
Re‐defining and tackling the emerging challenges in stem cell research and translation: A report of the 10th CSSCR annual meeting
Authors: Cao Jingyi , Hu Baoyang , Ji Weizhi 
Published: March 2022

AbstractThe 10th congress of the Chinese Society for Stem Cell Research was held from 11 to 13 October 2020 at Guiyang International Eco‐Conference Center in Guizhou (Southwest China) with 700 offline participants (and 500 online participants). With a theme adopted from a poem by Mao Zedong during the long march, ‘However difficult it might appear; the challenges will be overcome’, the congress provided opportunities for the fast‐growing field to exchange ideas among people from academia, industry and regulatory authorities, to help accelerate translation. Eight plenary lectures and six concurrent sessions on cell fate decision, stem cell metabolism, neural stem cells and neural regeneration, organoids and disease models, tissue and organ regeneration and clinical translation of stem cell research were covered, including 77 oral presentations and 75 poster presentations. The congress also included special programmes of a youth forum, a lecture award programme, a flagship journal forum and a dedicated networking session. This 3‐day event will significantly boost the stem cell research in an era closing to application.
Habitat Conservation Plans provide limited insight into the cost of complying with the Endangered Species Act
Authors: Surrey Katie C. , Iacona Gwenllian , Madsen Becca , Newman Christian , Gerber Leah R. 
Published: March 2022

AbstractThe Endangered Species Act (ESA) mandates protection for listed species, prohibiting intentionally adverse “take” by both public and private activities. The requirements can be perceived as a costly regulatory burden, although minimal understanding of the costs of compliance actions may exacerbate the perceived burden. This has potential consequences for ESA effectiveness and species recovery. We developed a framework to identify when compliance costs could be incurred in a project and then analyzed projected cost data from published Habitat Conservation Plans (HCPs) using this framework. We found that across HCPs, the projected costs reported were incomplete and difficult to interpret with inconsistent reporting across documents. Within the 43 HCPs that had utilizable cost data, the majority of projected costs (77%–97%) were incurred by implementation of ESA compliance activities. Of these, 46% of expected implementation costs were for monitoring efforts for project‐scale HCPs, while 81% of implementation costs for large‐scale projects were for compensatory mitigation actions. Our results provide a first attempt at analyzing the cost of ESA compliance actions using HCPs. However, we found that costs reported in HCPs tended to be opaque and incomplete, underscoring the need for standardization of cost reporting to better support understanding of ESA compliance costs.
Polarization, antipathy, and political activism
Authors: Wu Jiabin , Zhang Hanzhe 
Published: March 2022

AbstractWe present an evolutionary game theory model in which polarization, antipathy, and political activism are simultaneous consequences of the evolution of individuals' ideologies and their attitudes toward other ideologies. We show that the evolutionary process is likely to result in a vicious path with individuals becoming increasingly extreme and polarized on the ideological spectrum and the society ending up with two politically engaged groups sharing no common grounds and strong hatred against each other.