bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure of FeCrAl Overlay Welds on Superheater Tubes: Influence of Local Environment on Degradation
Authors: Valiente Bermejo M. A. , Magniez L. , Jonasson A. , Selin S. , Frodigh M. , Hurtig K. , Stridh L-E. , Karlsson L. 
Published: January 2022

AbstractTwo experimental FeCrAl alloy overlay welds on tube shields were exposed in the superheater of a full-size waste fired boiler for 6 months. The tube shields were in different tube lines and positions within the superheater chamber to investigate possible heterogeneities in the exposure environment. The visual inspection of the exposed tube shields and the corrosion-erosion rates calculated from the analysis of cross-sections showed that the mid-length roof location experienced the most aggressive environment. The compositional differences between the two experimental alloys were not found to be determinant in their performance under these specific exposure conditions. It was concluded that erosion had a decisive influence on the results. The identification of local differences within the superheater chamber is important when deciding on the material selection for the different areas and locations to be protected. The output of this study is therefore interesting for further design consideration of superheaters as well as for future planning of exposures.
Eligible strategies of drought response to improve drought resistance in woody crops: a mini-review
Authors: Carraro Elia , Di Iorio Antonino 
Published: January 2022

AbstractDrought is the main abiotic stress that negatively affects the crop yield. Due to the rapid climate change, actual plant defence mechanisms may be less effective against increased drought stress and other related or co-occurring abiotic stresses such as salt and high temperature. Thus, genetic engineering approaches may be an important tool for improving drought tolerance in crops. This mini-review focuses on the responses to drought stress of the woody crop species Olea europaea and Citrus sp., selecting in particular five main strategies adopted by plants in response to drought stress: aquaporin (AQPs) expression, antioxidant activity, ABA signalling, and trehalose and proline accumulation. Transgenic studies on both the herbaceous Arabidopsis and woody Populus plant models showed an improvement in drought resistance with increasing expression of these drought-inducible genes. Outcomes from the present study suggest the overexpression of the gene families associated with AQPs and ABA biosynthesis, mainly involved in regulating water transport and in preventing water loss, respectively, as candidate targets for improving drought resistance; antioxidants-, trehalose- and proline-related genes remain valid candidates for resistance to a wider spectrum of abiotic stressors, including drought. However, the contribution of an increased stiffness of the modulus elasticity of leaf parenchyma cell walls to the rapid recovery of leaf water potential, delaying by this way the stress onset, is not a secondary aspect of the transgenic optimization, in particular for Olea cultivars.
The effects of dimethyl fumarate and fingolimod on T-cell lymphocyte proliferation in patients with multiple sclerosis
Authors: Reynolds Audrey , Gaughan Maria , Holden Dean , Redenbaugh Vyanka , Dunne Jean , Redmond Janice , Conlon Niall 
Published: January 2022

Abstract
Objective
The disease-modifying therapies (DMT), dimethyl fumarate (DMF) and fingolimod (FTY) improve the outcomes in multiple sclerosis (MS) by reducing relapses and numbers and volume of lesions. They mediate their effects through reduction of immune reactivation, which may potentially lead to lymphopaenia and increased risk of infections. Previous studies have examined the effects of these therapies on lymphocyte subsets; however, the in vivo effects on circulating lymphocyte proliferation require further elucidation. The aim of this study was to determine the effects of DMF and FTY on T-cell proliferation in patients with MS.

Method
We examined T-cell lymphocyte proliferation and lymphocyte subsets in ten patients (five on DMF, five on FTY) before starting DMT and again 4 to 11 months after being maintained on DMT.

Results
In the FTY-treated group, the mean percentage proliferation was significantly lower using both assays (PHA assay mean percentage change − 51.2 ± 25.97, p < 0.05; anti-CD3/CD28 assay mean percentage change − 39.74 ± 27.85, p < 0.05). There was no statistical difference in T-cell lymphocyte proliferation in the DMF-treated group for either assay (PHA, p = 0.316; anti-CD3/CD28, p = 0.373).

Conclusions
This pilot study suggests that the T-lymphocytes of patients on FTY have an abnormal proliferation response as well as being reduced in the circulation.
Curcuma longa L. Prevents the Loss of β-Tubulin in the Brain and Maintains Healthy Aging in Drosophila melanogaster
Authors: Rahman Md. Mashiar , Noman Md. Abdullah Al , Hossain Md. Walid , Alam Rahat , Akter Selena , Kabir Md. Masnoon , Uddin Mohammad Jashim , Amin Md. Ziaul , Syfuddin H. M. , Akhter Shahina , Karpiński Tomasz M. 
Published: January 2022

AbstractLoss of tubulin is associated with neurodegeneration and brain aging. Turmeric (Curcuma longa L.) has frequently been employed as a spice in curry and traditional medications in the Indian subcontinent to attain longevity and better cognitive performance. We aimed to evaluate the unelucidated mechanism of how turmeric protects the brain to be an anti-aging agent. D. melanogaster was cultured on a regular diet and turmeric-supplemented diet. β-tubulin level and physiological traits including survivability, locomotor activity, fertility, tolerance to oxidative stress, and eye health were analyzed. Turmeric showed a hormetic effect, and 0.5% turmeric was the optimal dose in preventing aging. β-tubulin protein level was decreased in the brain of D. melanogaster upon aging, while a 0.5% turmeric-supplemented diet predominantly prevented this aging-induced loss of β-tubulin and degeneration of physiological traits as well as improved β-tubulin synthesis in the brain of D. melanogaster early to mid-age. The higher concentration (≥ 1%) of turmeric-supplemented diet decreased the β-tubulin level and degenerated many of the physiological traits of D. melanogaster. The turmeric concentration-dependent increase and decrease of β-tubulin level were consistent with the increment and decrement data obtained from the evaluated physiological traits. This correlation demonstrated that turmeric targets β-tubulin and has both beneficial and detrimental effects that depend on the concentration of turmeric. The findings of this study concluded that an optimal dosage of turmeric could maintain a healthy neuron and thus healthy aging, by preventing the loss and increasing the level of β-tubulin in the brain.
Intersectoral and spatial spill-overs of firms’ bankruptcy in Spain
Authors: Serra Laura , Detotto Claudio , Juan Pablo , Vannini Marco 
Published: January 2022

AbstractThis paper employs provincial data to study the spatial and intersectoral spill-overs in aggregate failure rates in Spain, by using an Integrated Nested Laplace Approximation. The analysis is based on NUTS3 data over the time span 2005Q1-2013Q4. By speculating on the effects of the Spanish financial crisis, we document empirical evidence of the presence of spatial spill-overs among neighboring counties. Furthermore, some intersectoral spill-overs are also detected: we observe that Industry and Agriculture exhibit a positive impact on the Service sector. These results can be useful to design proper policy rules to better manage the spread of bankruptcies over time and space.
The Work Environment of Immigrant Employees in Sweden—a Systematic Review
Authors: Akay Pinar Aslan , Ahmadi Nader 
Published: January 2022

AbstractThe aim of this systematic review was to summarize and synthesize research results focusing on the work environment of employees with an immigrant background in Sweden. We focus on the main conditions identified in the working environment of immigrant employees and how these conditions may affect their health and well-being. The concept of “minority stress” and the attachment theory are used to understand and interpret the findings. We systematically searched for literature published between the years of 1990 and 2020 in four databases, Web of Science, PubMed, SocIndex, and Academic Search Elite. We started the selection process by reading title and abstracts, then proceeded to read a selection of full-text studies and eliminated those that did not fulfil the inclusion criteria. We did a quality assessment on the full-text studies based on the MMAT-tool, and then performed a narrative synthesis of the results. The results show that immigrants experience several stressors in their work environment, including physical, psychological, and social risks. These risks are, among other things, associated with the nature of the jobs that immigrants are overrepresented in, with minority-related stressors such as discrimination, harassment, and threats on the basis of ethnic background, and with the lack of social support from managers and colleagues. Results also highlight beneficial factors in the immigrants’ working environment and show the importance of a supportive, inclusive, and empowering management. Our main conclusion is that Swedish workplaces need to introduce more active measures to raise awareness of and combat workplace discrimination, work harder to promote inclusion at the workplace, and eliminate physical, psychological, and social health hazards specific to immigrant employees. The leadership and management have an important role to play here, as does the employees’ trade unions and its special functions.
Optimizing Health and Athletic Performance for Women
Authors: de Borja Celina , Chang Cindy J. , Watkins Rhonda , Senter Carlin 
Published: January 2022

Abstract
Purpose of Review
The exponential growth of women participating in competitive sports throughout the years was made possible through several initiatives by the International Olympic Committee and the passage and implementation of Title IX as a federal law in the United States. However, this positive trend towards gender equity in sports has not transpired for women in medicine, especially in fields that care for elite athletes. This current review will discuss specific areas that can be tailored to help female athletes prevent injuries and optimize their athletic performance. We will also highlight how increased female team physician representation in sports may help optimize care for female athletes.

Recent Findings
Female athletes are considered high risk for certain conditions such as ACL tears, patellofemoral pain syndrome, bone stress injuries, sport-related concussions, and sexual violence in sport. Addressing factors specific to female athletes has been found to be valuable in preventing injuries. Strength and conditioning can optimize athletic performance but remains underutilized among female athletes. Although diversity in healthcare workforce has been found to be beneficial for multiple reasons, women remain underrepresented in sports medicine. Increasing female team physician representation may positively impact care for female athletes.

Summary
Team physicians must understand the physiologic, biomechanical, and anatomic factors that are unique to female athletes in order to tailor injury prevention programs and optimize their athletic performance. Advocating for gender equity in sports medicine to advance representation of women in the field will increase workforce diversity and promote excellence in sports medicine care.
Single HER2-positive tumor cells are detected in initially HER2-negative breast carcinomas using the DEPArray™–HER2-FISH workflow
Authors: Grüntkemeier Lisa , Khurana Aditi , Bischoff Farideh Zamaniyan , Hoffmann Oliver , Kimmig Rainer , Moore Mathew , Cotter Philip , Kasimir-Bauer Sabine 
Published: January 2022

Abstract
Background
In breast cancer (BC), overexpression of HER2 on the primary tumor (PT) is determined by immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH) to stratify samples as negative, equivocal and positive to identify patients (pts) for anti-HER2 therapy. CAP/ASCO guidelines recommend FISH for analyzing HER2/neu (ERBB2) gene amplification and for resolving equivocal HER2 IHC results. However, pre-analytical and analytical aspects are often confounded by sample related limitations and tumor heterogeneity and HER2 expression may differ between the PT and circulating tumor cells (CTCs), the precursors of metastasis. We used a validation cohort of BC patients to establish a new DEPArray™-PT-HER2-FISH workflow for further application in a development cohort, characterized as PT-HER2-negative but CTC-HER2/neu-positive, to identify patients with PT-HER2 amplified cells not detected by routine pathology.

Methods
50 µm FFPE tumor curls from the validation cohort (n = 49) and the development cohort (n = 25) underwent cutting, deparaffinization and antigen retrieval followed by dissociation into a single-cell suspension. After staining for cytokeratin, vimentin, DAPI and separation via DEPArray™, single cells were processed for HER2-FISH analysis to assess the number of chromosome 17 and HER2 loci signals for comparison, either with available IHC or conventional tissue section FISH. CTC-HER2/neu status was determined using the AdnaTest BreastCancer (QIAGEN, Hilden, Germany).

Results
Applying CAP/ASCO guidelines for HER2 evaluation of single PT cells, the comparison of routine pathology and DEPArray™-HER2-FISH analysis resulted in a concordance rate of 81.6% (40/49 pts) in the validation cohort and 84% (21/25 pts) in the development cohort, respectively. In the latter one, 4/25 patients had single HER2-positive tumor cells with 2/25 BC patients proven to be HER2-positive, despite being HER2-negative in routine pathology. The two other patients showed an equivocal HER2 status in the DEPArray™-HER2-FISH workflow but a negative result in routine pathology. Whereas all four patients with discordant HER2 results had already died, 17/21 patients with concordant HER2 results are still alive.

Conclusions
The DEPArray™ system allows pure tumor cell recovery for subsequent HER2/neu FISH analysis and is highly concordant with conventional pathology. For PT-HER2-negative patients, harboring HER2/neu-positive CTCs, this approach might allow caregivers to more effectively offer anti-HER2 treatment.
Reducing impacts of rice fields nitrate contamination on the river ecosystem by a coupled SWAT reservoir operation optimization model
Authors: Sedighkia Mahdi , Datta Bithin , Abdoli Asghar 
Published: January 2022

Abstract The present study proposes a multipurpose reservoir operation optimization for mitigating impact of rice fields’ contamination on the downstream river ecosystem. The developed model was applied in the Tajan River basin in Mazandaran Province, Iran, in which the rice is the main crop. We used soil and water assessment tool (SWAT) to simulate inflow of the reservoir and nitrate load at downstream river reach. Nash–Sutcliffe model efficiency coefficient was used to measure the robustness of SWAT. NSE indicated that SWAT is acceptable to simulate nitrate load of the rice fields. The results of SWAT was applied in the structure of a multipurpose reservoir operation optimization in which three metaheuristic algorithms including differential evolution algorithm, particle swarm optimization and biogeography-based algorithm were utilized in the optimization process. Reliability index, mean absolute error and failure index were used to measure the robustness of the optimization algorithms. Fuzzy Technique for Order of Preference by Similarity to Ideal Solution was utilized to select the best algorithm. Based on results, particle swarm optimization is the best method to optimize reservoir operation in the case study. The reliability index and mean absolute error for water supply are 0.6 and 5 million cubic meters, respectively. Furthermore, the failure index of contamination is 0.027. Hence, it could be concluded that the proposed optimization system is reliable and robust to mitigate losses and nitrate contamination simultaneously. However, its performance is not perfect for minimizing impact of contamination in all the simulated months.
Fin actuation, thrust vector control and landing leg mechanisms design for the RETALT VTVL launcher
Authors: Krammer Anett , Blecha Luc , Lichtenberger Marc 
Published: January 2022

AbstractTo foster the competitiveness of the European industry in the global launcher market, the need arose to build up the necessary know-how on state-of-the-art vertical take-off vertical landing (VTVL) concepts and corresponding technologies. In the EU Horizon 2020 project RETALT (RETro propulsion Assisted Landing Technologies), the VTVL approach applying retro propulsion is investigated for two-stage-to-orbit (TSTO) and single-stage-to-orbit (SSTO) reusable launch vehicles, these configurations are named RETALT1 and RETALT2. In the project framework investigation of both reference configurations is performed in several areas: aerodynamics, aerothermodynamics, flight dynamics and guidance, navigation, and control (GNC), as well as thermal protection and structures and mechanisms. Focusing on solutions for the RETALT 1 launch vehicle, Almatech contributes with the design of mechanisms to actuate the aerodynamic controls surfaces, retain and deploy the landing legs and provide means to dissipate energy during touch-down. Demonstrators of these mechanism are also built during the project. In addition to the above activities, Almatech proposes thrust vectoring solutions. This paper presents an overview of these activities and results obtained so far.
Fooled by facts: quantifying anchoring bias through a large-scale experiment
Authors: Yasseri Taha , Reher Jannie 
Published: January 2022

AbstractThrough a large-scale online field experiment, we provide new empirical evidence for the presence of the anchoring bias in people’s judgement due to irrational reliance on a piece of information that they are initially given. The comparison of the anchoring stimuli and respective responses across different tasks reveals a positive, yet complex relationship between the anchors and the bias in participants’ predictions of the outcomes of events in the future. Participants in the treatment group were equally susceptible to the anchors regardless of their level of engagement, previous performance, or gender. Given the strong and ubiquitous influence of anchors quantified here, we should take great care to closely monitor and regulate the distribution of information online to facilitate less biased decision making.
Laparoscopic splenectomy: how minimal can we make it?
Authors: Fadipe Adetokunbo , Wilkinson David , Peters Robert , Doherty Catherine , Lansdale Nick 
Published: January 2022

AbstractAimsLaparoscopic splenectomy (LS) is routinely performed in children, however, a large spleen in a small child can pose significant operative challenges. We instigated a highly standardised surgical and anaesthetic approach to LS to minimise surgical trauma and enhance recovery. The aim of this study was to assess the outcomes of this programme.MethodsProspective study of all LS’s performed 2018–2021. Surgical approach was via one 10 mm and three 5 mm ports. Early hilar control was accomplished with Hem-o-loks. Splenic retrieval via the 10 mm incision used finger morcellation within an Espiner EcoSac. Anaesthesia utilised a standardised regime of agents and bupivacaine was infiltrated to the splenic bed and wound sites. Post-operative opiates were minimised. Data are presented as median [IQR].ResultsTwenty consecutive children were included. Indications for LS were hereditary spherocytosis (n = 12), sickle cell disease (n = 6), beta-thalassaemia (n = 1) and splenic haemangiomatosis (n = 1). Age at surgery was 101 months [75–117] and weight 30 kg [21–37]. Splenic size was 13.4 cm [12–14.4]. Operative time was 178 min [156–185]. There were no open conversions and no significant intra or post-operative bleeding. One patient developed pancreatitis. Median post-operative pain score was 1 [1–3]. Median length of stay was 2 days [2–3].ConclusionLS is feasible, safe and efficient in smaller children with large spleens. This standardised programme of anaesthesia and surgery based around a core team reliably results in few complications, good analgesia and short length of stay.
Influence of regeneration process parameters on geometry and defects of clearance surface of planer knives used in wood planing process
Authors: Sutowski Paweł , Nadolny Krzysztof , Sutowska Marzena , Myśliński Piotr , Gilewicz Adam , Warcholiński Bogdan 
Published: January 2022

Abstract
A properly implemented strategy regarding the planer knife regeneration process, may not only restore the original cutting ability of the tool, but even increase its operational quality, including its durability for industrial woodworking processes. This article presents experimental results and discussion in respect of sharpening planer knives with cubic boron nitride grinding wheels. Both the grinding conditions and machining surface quality were analyzed. Application of improper size or loads of abrasive grains may lead to the appearance of grinding burns on a machined surface, or result in a surface with cracks and grooves. The results of the measurements carried out indicate that surfaces with reduced values of roughness and waviness parameters can be obtained, even up to 22% (as in the case of the reduced peak height parameter, Spk) in relation to new knives, prepared at a factory. The value of St and Sds parameters are almost the same as reference knife (deviation up to 3%). Due to machining marks, the total waviness exceeds 33%. Our research also shows that due to the technological quality of the knife surfaces, it is beneficial to use CBN grains with a low depth of cut (a
e no more than 0.02 mm), but a moderate or high feed rate (the best choice is about 470 mm/min for v
ft). Presented results constitute an important know-how for the grinding process with the use of grinders used by operators (like WEINIG Rondamat 980) during the sharpening of planer cutter heads in the wood industry.
Exploring discourse-based organizational change in Japan: practicing between dominant and alternative discourses
Authors: Nagaishi Makoto 
Published: January 2022

AbstractThe primary objective of this study is to respond to Grant and Marshak’s (J Appl Behav Sci 47:204–235, 2011) call for a move toward change perspectives that emphasize the generative nature of discourses, narratives, and conversations and how change practitioners discursively facilitate emergent processes. This article attempts to explore the question, “Can we specify the conditions and sources which make generative conversations emerge and may lead to a successful change effort in Japan?” The abductive inquiry into the question indicates that the generative change process convinces change sponsors that changing the dominant discourses and welcoming alternative ones can lead to the long-term development of the organization and the members. With respect to the sources of alternative discourses, psychological safety and trust in the external authority figure are generally required. The importance of survival anxiety and talent diversity may vary across the broad contexts on which organizations depend.