bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Oppressor’s Dilemma
Authors: LeFebvre Jesse R. 
Published: July 2022

Abstract
For the last thirty-five years, the majority of Japanese wedding ceremonies have involved Christianity, but scholars have struggled with Christianity’s increasingly prominent place within the Japanese religious landscape. The tendency has been to refute the religiosity of Christian weddings and embrace the rhetoric of Japanese essentialism. However, following its prohibition in 1612, the ongoing “eradication” of Christianity defined the very nature of Japanese subjecthood, made Christianity indispensable to the Japanese state, and entrenched ritualized acts of disassociation from the religion within the lives of every individual. Modern arguments, too, continue to assert Christianity’s foreignness, portraying it as the religion of colonialism or contending that “foreign” conceptions of religion are inappropriate within the Japanese context. However, the popularity of Christian wedding ceremonies within the context of postwar Japan owes much to prewar and wartime Japanese state policy where the Japanese government adopted policies toward religion that helped set the stage for the later acceptance of the Christian marriage rite.
A Dual-Attention Mechanism Deep Learning Network for Mesoscale Eddy Detection by Mining Spatiotemporal Characteristics
Authors: Li Baixin , Tang Huan , Ma Dongfang , Lin Jianmin 
Published: July 2022

Abstract
Mesoscale eddies are a mechanism for ocean energy transfer, and identifying them on a global scale provides a means of exploring ocean mass and energy exchange between ocean basins. There are many widely used model-driven methods for detecting mesoscale eddies; however, these methods are not fully robust or generalizable. This study applies a data-driven method and proposes a mesoscale detection network based on the extraction of eddy-related spatiotemporal information from multisource remote sensing data. Focusing on the northwest Pacific, the study first analyzes mesoscale eddy characteristics using a combination of gridded data for the absolute dynamic topography (ADT), sea surface temperature (SST), and absolute geostrophic velocity (UVG). Then, a deep learning network with a dual-attention mechanism and a convolutional long short-term memory module is proposed, which can deeply exploit spatiotemporal feature relevance while encoding and decoding information in the gridded data. Based on the analysis of mesoscale eddy characteristics, ADT and UVG gridded data are selected to be the inputs for the detection network. The experiments show that the accuracy of the proposed network reaches 93.38%, and the weighted mean dice coefficient reaches 0.8918, which is a better score than those achieved by some of the detection networks proposed in previous studies, including U-Net, SymmetricNet, and ResU-Net. Moreover, compared with the model-driven approach used to generate the ground-truth dataset, the network method proposed here demonstrates better performance in detecting mesoscale eddies at smaller scales, partially addressing the problem of ghost eddies.
Poster 167: Biomechanics of a Novel Dermal Augmentation Procedure for Subcritical Bone Loss
Authors: Wynkoop Aaron , Wang Patrick , Konicek John , Akhavan Sam 
Published: July 2022

Objectives: Subcritical glenoid bone loss has been associated with high failure rates when treated with standard labral repair. While a Latarjet can provide stability, high complication rates and the risk of long term arthritis makes this procedure less then ideal when bone loss is under 20%. The purpose of the current study was to demonstrate biomechanical results of a new arthroscopic procedure using dermal allograft augmentation of subcritical bone loss when compared to a standard labral repair for subcritical bone loss. Methods: Six cadaveric specimens were prepared sequentially to simulate four clinical scenarios (Figure 1): 1) an intact shoulder; 2) a 15% bony glenoid defect; 3) 15% defect repaired using a 3-anchor labral; and 4) Dermal Allograft augmentation of the bony defect. The glenoid was potted on a ball-bearing base allowing horizontal degrees of freedom, with 50N weights applied to simulate intra-articular compression. The humerus was potted and placed in an Instron at 45 degrees of abduction, allowing anterior translation to dislocation. Translation (mm) and force (N) to dislocation were measured, using ANOVA for statistical analysis. Results: Dermal augmentation of the 15% defect resulted in a significantly higher force to dislocation (20.53+/-7.76N) when compared to the defect group (14.75+/-4.99N, p=0.002) or the labral repair (13.94+/-4.13N, p=0.007). There was no difference between the force to dislocation between the defect and labral repair groups (p=1.0). The intact shoulder translated 8.37+/-1.06mm prior to dislocation. This was significantly higher than both the defect (5.23 +/- 0.65mm, p<0.001) or the labral repair (6.55+/-0.97mm, p=0.048). The dermal augmentation resulted in no significant difference in anterior translation to dislocation (8.92 +/- 4.13mm, p=1.0). Conclusions: While labral repair is often used in patients with subcritical bone loss, clinical failure rates are high, ranging from 25-100%. Results of the current study indicate that a standard labral repair does not restore the force to dislocation when used in a 15% defect. On the contrary, it may lead to tightening of the shoulder in a non-anatomic position, resulting in the repair being “tested” at earlier range of motions. This may cause the repair to stretch during every day range of motion. Dermal augmentation of the glenoid defect can restore the normal anterior translation of the shoulder, while also increasing the force to dislocation when compared to a standard repair.
Poster 184: Effect of Younger Starting Pitching Age on Humeral Retrotorsion in Baseball Pitchers With an Ulnar Collateral Ligament Injury
Authors: Hannon Joseph , Conway John , Creed Kalyssa , Garrison Craig , Kennedy Sean 
Published: July 2022

Objectives: Increased humeral retrotorsion (HRT) has been found to be a risk factor for ulnar collateral ligament (UCL) tears in baseball players. Recent work has demonstrated the age of 11 years as a potential watershed age for HRT development. In a group of baseball pitchers with UCL injuries, athletes who started pitching before the age of 10 years will demonstrate significantly more dominant limb humeral retrotorsion (DHRT) when compared with a group of baseball pitchers who reported starting pitching at 10 years or older. Methods: A total of 84 baseball pitchers with a diagnosed UCL injury were divided into 2 groups based upon the age at which participants began pitching: 33 players reporting a starting pitching age of 10 years or older (group 1) were compared with 51 baseball pitchers reporting a starting pitching age under 10 years (group 2). Participants’ DHRT and nondominant limb humeral retrotorsion (NDHRT) were measured using diagnostic ultrasound. Independent t tests were run to compare mean group differences of all patient data, starting pitching age, age at time of injury, DHRT, NDHRT, and humeral retrotorsion difference (HRTdiff). Results: There were no significant differences between groups with regard to age at time of injury, height, weight, or playing years’ experience. There was a statistically significant difference in the participant-reported starting pitching age. Significant differences between groups were noted for DHRT (group 1: 20.0°± 9.4°, group 2: 14.5°± 10.3°, P = .015) and for NDHRT (group 1: 38.6°± 8.8°, group 2: 32.9°± 9.5°, P = .007). No significant differences between groups were found for HRTdiff (P = .940). Conclusions: Baseball pitchers with a UCL injury who reported a starting pitching age younger than 10 years demonstrated significantly greater DHRT and NDHRT when compared with UCL-injured baseball pitchers who reported a starting pitching age at 10 years or later. The results of this study demonstrate that a younger starting pitching age results in increased HRT in players with UCL injuries. [Figure: see text]
Poster 194: Recall Bias in the Retrospective Collection of Common Pre-Operative Patient-Reported Outcome Measures in Hip Arthroscopy
Authors: Crutchfield Connor , Givens Ritt , O’Connor Michaela , Lynch T. Sean 
Published: July 2022

Objectives: To assess for the presence of recall bias between prospectively and retrospectively collected patient-reported outcome (PRO) scores in hip arthroscopy (HA). Methods: Patients that underwent HA between 2015-2021 and provided pre-operative baseline responses for the International Hip Outcome Tool-12 (iHOT-12), the Hip Disability and Osteoarthritis Outcome Score Physical Shortform (HOOS-PS), and the modified Harris Hip Score (mHHS) were eligible for recruitment. Eligible participants were asked to complete a study-specific survey and the same preoperative PROs retrospectively, requiring them to recall the status of the hip prior to surgery. Agreement between the prospective and retrospective scores was assessed using a two-way mixed effects intraclass coefficient (ICC) model. Paired t-tests were used to compare the mean scores of both groups and linear regression models were used to help identify associations between score discrepancies and patient characteristics. Results: A total of 222 patients were approached for participation, of whom 104 (60.6% female) completed study requirements and were included for analysis. The mean duration of symptoms before surgery was 24.5 ± 31.8 months and the mean duration to recall (from the day of surgery) for the retrospective completion of hip surveys was 29.1 ± 21.8 months. The iHOT-12 had a low amount of agreement between prospective and retrospectively collected scores (ICC=.452; P =.000). HOOS-PS scores also had a low amount of agreement (ICC=.458; P =.000). The mHHS had a moderate amount of agreement (ICC=.621; P =.000). Mean scores for iHOT-12 (41.5 ± 22.6 vs. 35.3 ± 17.7; P <.01), HOOS-PS (29.5 ± 18.9 vs 40.7 ± 17.9; P <.001), and mHHS (62.9 ± 16.5 vs 55.1 ± 15.3; P <.001) were all significantly different prospectively vs. retrospectively. The average changes in score observed for the iHOT-12, HOOS-PS, and mHHS were -6.2, 11.2, and -7.8, respectively. Multiple linear regression identified duration to recall and sex as significant predictors of the absolute difference between prospective and retrospectively collected iHOT-12 data while sex alone was predictive of a difference in HOOS-PS data. Conclusions: The retrospective collection of patient-reported outcomes for hip arthroscopy procedures, which requires patient recall of their preoperative condition, is subject to bias and inaccuracy. Recalled PROs consistently reflected worse pain/function than their prospectively recorded counterpoints; therefore, retrospective patient recall is an unreliable source of clinical data and the prospective collection of iHOT-12, mHHS, and HOOS-PS data should be prioritized. [Figure: see text][Figure: see text][Table: see text]
Poster 262: Correlation of Tanner Stage and Hypermobility with Meniscal and Articular Cartilage Injury in the Pluto Cohort
Authors: Gibian Joseph , Hutchinson Lauren , Miller Patricia , Kocher Mininder , Matava Matthew 
Published: July 2022

Objectives: To determine whether the relationship between hypermobility and meniscal and/or articular cartilage injury varies by stage of pubertal development. Patients with hypermobility will have a lower risk of meniscal and articular cartilage injury than patients with normal laxity. Methods: At 10 geographically diverse institutions in the United States, consecutive skeletally immature patients diagnosed with complete ACL tears between January 2016 and April 2020 were enrolled. Beighton score was collected at the preoperative physical exam; bone age was determined from a hand/wrist radiograph; and the presence of meniscal tears and articular cartilage injuries was collected from the surgical assessment. Tanner stage was documented at time of surgery. Univariable and multivariable logistic regression analysis was used to assess the effect of Tanner stage and Beighton score on the likelihood of cartilage injury and meniscal tear. Results: Seven hundred forty-seven skeletally immature patients with complete ACL tears were analyzed with an average age at surgery of 12.3 years; the cohort was 62% male. Eighty-five patients had documented cartilage injuries for an event rate of 11.4%. Bivariate analysis found that those with cartilage injuries had a slightly higher bone age (13.9 versus 13.1 years; p=0.001) and a higher Tanner stage (p=0.009). For each additional Tanner stage, the odds of cartilage injury increased by approximately 1.6 (p<0.001). No association was detected between hypermobility and the likelihood of a cartilage injury. Four hundred twenty-three patients had documented meniscal tears for an event rate of 56.6%. Bivariate analysis found that those with meniscal tears were slightly older (12.6 versus 12.0 years; p<0.001), had a slightly higher bone age (13.5 versus 12.8 years; p<0.001) and a higher Tanner stage (p=0.002). For each additional Tanner stage, the odds of a meniscal tear increased by approximately 1.3 times (p<0.001). No association was detected between hypermobility and the likelihood of a meniscal tear. Conclusions: There is a high rate of concomitant articular cartilage and meniscal injuries in skeletally immature patients who sustain ACL tears. The risk of concurrent injury is associated with increasing bone age and Tanner score. There was no association between these concurrent injuries and hypermobility. [Figure: see text][Figure: see text]
Intraocular lymphoma masquerading as unilateral hypopyon anterior uveitis: a case report
Authors: Zamani Ghodsieh , Hajipour Atefeh , Ganjeifar Babak , Ebrahimiadib Nazanin , Hosseini Seyedeh Maryam 
Published: July 2022

Abstract
Purpose
To report an unusual case of unilateral anterior segment large B-cell intraocular lymphoma (IOL) presenting as a recurrent hypopyon anterior uveitis.

Case presentation
A 55-year-old female was referred because of recurrent unilateral anterior hypopyon uveitis with partial response to topical corticosteroid. All of the laboratory tests, review of systems and ocular sampling results were unremarkable. Given a high concern for masquerades syndromes, cytological specimens were obtained 3 times and the last sample showed large B cell lymphoma. First, it appeared confined to the eye and initially responded favorably to local chemotherapy (methotrexate and rituximab) but later went on to develop systemic involvement. CNS lymphoma was detected on the third brain MRI 6 months following ocular involvement. At this time, systemic chemotherapy was started. In the last 18 months’ follow-up, visual acuity was 20/30 in the right eye without posterior segment or fellow eye involvement.

Conclusion
Unusual presentation of intraocular lymphoma as a unilateral isolated anterior hypopyon uveitis should be kept in mind. This report emphasizes the importance of precise work-ups and multiple ocular biopsies to confirm the diagnosis of intraocular lymphoma.
Tandem repeats ubiquitously flank and contribute to translation initiation sites
Authors: Maddi Ali M. A. , Kavousi Kaveh , Arabfard Masoud , Ohadi Hamid , Ohadi Mina 
Published: July 2022

AbstractBackgroundWhile the evolutionary divergence ofcis-regulatory sequences impacts translation initiation sites (TISs), the implication of tandem repeats (TRs) in TIS selection remains largely elusive. Here, we employed the TIS homology concept to study a possible link between TRs of all core lengths and repeats with TISs.MethodsHuman, as reference sequence, and 83 other species were selected, and data was extracted on the entire protein-coding genes (n = 1,611,368) and transcripts (n = 2,730,515) annotated for those species from Ensembl 102. Following TIS identification, two different weighing vectors were employed to assign TIS homology, and the co-occurrence pattern of TISs with the upstream flanking TRs was studied in the selected species. The results were assessed in 10-fold cross-validation.ResultsOn average, every TIS was flanked by 1.19 TRs of various categories within its 120 bp upstream sequence, per species. We detected statistically significant enrichment of non-homologous human TISs co-occurring with human-specific TRs. On the contrary, homologous human TISs co-occurred significantly with non-human-specific TRs. 2991 human genes had at least one transcript, TIS of which was flanked by a human-specific TR. Text mining of a number of the identified genes, such asCACNA1A, EIF5AL1, FOXK1, GABRB2, MYH2, SLC6A8,andTTN, yielded predominant expression and functions in the human brain and/or skeletal muscle.ConclusionWe conclude that TRs ubiquitously flank and contribute to TIS selection at the trans-species level. Future functional analyses, such as a combination of genome editing strategies and in vitro protein synthesis may be employed to further investigate the impact of TRs on TIS selection.
Interleukin 20 receptor subunit beta (IL20RB) predicts poor prognosis and regulates immune cell infiltration in clear cell renal cell carcinoma
Authors: Zhang Haoxun , Liu Yiwen , Wang Bowen , Wang Chunyang 
Published: July 2022

AbstractBackground and objectiveEmerging evidence has proven the robust role of tumor mutation burden (TMB) and immune cell infiltration (ICI) in cancer immunotherapy. However, the precise effect of TMB and ICI on clear cell renal cell carcinoma (ccRCC) remains elusive and merits further investigation. Therefore, we aim to identify the TMB-related genes in predicting prognosis and to explore the potential mechanisms of the identified Interleukin 20 receptor subunit beta (IL20RB) in ICI in ccRCC.MethodThe relative information of patients with ccRCC was obtained from The Cancer Genome Atlas database (TCGA). Immune-related genes were downloaded from the Immunology Database and Analysis Portal database. Cox regression analysis was used to identify prognosis-related immune genes for ccRCC. The relationship ofIL20RBexpression levels with clinicopathological parameters was analyzed using the “limma” and “survival” packages. Gene Expression Omnibus (GEO) and International Cancer Genome Consortium (ICGC) databases were used as external validation. Quantitative Real-time PCR (qRT-PCR) and western blots were used to validate the expression levels ofIL20RBin tumor cells. Cell counting kit-8 (CCK-8) assay and colony formation assay were used to examine the effect ofIL20RBon the viability of ccRCC cells. Gene set enrichment analysis (GSEA) was introduced for the analysis ofIL20RB-related signaling pathways. Tumor Immune Estimation Resource (TIMER) and Tumor and Immune System Interaction Database (TISIDB) were utilized to determine the correlation ofIL20RBexpression levels with tumor-infiltrating immune cells (TIICs).ResultsIL20RBwas significantly overexpressed in different ccRCC tissues and cells. HighIL20RBexpression in ccRCC patients was associated with short overall survival, high tumor grade, and advanced TNM stage. After knockdown ofIL20RBwith small interfering RNA (siRNA) technology, ccRCC cells’ proliferation was significantly attenuated. Moreover, overexpression ofIL20RBcould increase the infiltration level of several immune cells, especially T follicular helper cells (Tfh), and overexpressed Tfh cells were correlated with poor prognosis in ccRCC.ConclusionsIL20RBmay function as an immune-associated therapeutic target for it determines cancer progression and regulates immune cell infiltration in ccRCC.
In silico discovery of blood cell macromolecular associations
Authors: Gautvik Kaare M. , Sachse Daniel , Hinton Alexandra C. , Olstad Ole K. , Kiel Douglas P. , Hsu Yi-Hsiang , Utheim Tor P. , Lary Christine W. , Reppe Sjur 
Published: July 2022

AbstractBackgroundPhysical molecular interactions are the basis of intracellular signalling and gene regulatory networks, and comprehensive, accessible databases are needed for their discovery. Highly correlated transcripts may reflect important functional associations, but identification of such associations from primary data are cumbersome. We have constructed and adapted a user-friendly web application to discover and identify putative macromolecular associations in human peripheral blood based on significant correlations at the transcriptional level.MethodsThe blood transcriptome was characterized by quantification of 17,328 RNA species, including 341 mature microRNAs in 105 clinically well-characterized postmenopausal women. Intercorrelation of detected transcripts signal levels generated a matrix with > 150 million correlations recognizing the human blood RNA interactome. The correlations with calculated adjustedp-values were made easily accessible by a novel web application.ResultsWe found that significant transcript correlations within the giant matrix reflect experimentally documented interactions involving select ubiquitous blood relevant transcription factors (CREB1, GATA1, and the glucocorticoid receptor (GR, NR3C1)). Their responsive genes recapitulated up to 91% of these as significant correlations, and were replicated in an independent cohort of 1204 individual blood samples from the Framingham Heart Study. Furthermore, experimentally documented mRNAs/miRNA associations were also reproduced in the matrix, and their predicted functional co-expression described. The blood transcript web application is available athttp://app.uio.no/med/klinmed/correlation-browser/blood/index.phpand works on all commonly used internet browsers.ConclusionsUsing in silico analyses and a novel web application, we found that correlated blood transcripts across 105 postmenopausal women reflected experimentally proven molecular associations. Furthermore, the associations were reproduced in a much larger and more heterogeneous cohort and should therefore be generally representative. The web application lends itself to be a useful hypothesis generating tool for identification of regulatory mechanisms in complex biological data sets.
Is cell regeneration and infiltration a double edged sword for porcine aortic valve deterioration? A large cohort of histopathological analysis
Authors: Li Li , Duan Xuejing , Wang Hongyue , Sun Yang , Zhao Wei , Lu Yang , Xu Hongyu , You Yiwei , Wang Qingzhi 
Published: July 2022

AbstractBackground and objectiveBioprostheses are the most common prostheses used for valve replacement in the Western medicine. The major flaw of bioprostheses is the occurrence of structural valve deterioration (SVD). This study aimed to assess the pathological features of porcine aortic valve (PAV)-SVD based on histomorphological and immunopathological characteristics of a large cohort of patients.MethodsHistopathological data of 109 cases with resected PAV were collected. The type and amount of infiltrated cells were evaluated in the different types of bioprosthetic SVD by immunohistochemical staining.ResultsThe most common cause of SVD was calcification, leaflet tear, and dehiscence (23.9%, 19.3%, and 18.3%, respectively). Immunohistochemical staining demonstrated that macrophages were infiltrated in the calcified, lacerated and dehiscence PAV, in which both M1 and M2 macrophages were existed in the calcified PAV. Importantly, the higher content of M1 macrophages and less content of M2 macrophages were found in the lacerated and dehiscence PAV, and MMP-1 expression was mainly found in the lacerated PAV. The endothelialization rate of leaflet dehiscence was higher than that of calcified and lacerated leaflets. A large number of CD31+/CD11b+ cells was aggregated in the spongy layer in the lacerated and dehiscence PAV.ConclusionCell regeneration and infiltration is a double edged sword for the PAV deterioration. Macrophage infiltration is involved in the different types of SVD, while only MMP-1 expression is involved in lacerated leaflets. The macrophage subtype of circulating angiogenic cells in dehiscence and tear PAV could be identified, which could reserve macrophages in the PAV-SVD.