bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of intelligent and expert system for automation of processes of mining and transport works on the basis of satellite navigation
Authors: Kaimov Aidarkhan , Kaimov Abylay , Kaimov Suleimen , Kaiym Talgat , Primbetova Altynay , Mamyrbaev Orken , Nysanbayeva Saule , Serikbayeva Karakoz 
Published: May 2022

The object of research relates to the field of control systems for mining and transport machines in the development of deposits of solid minerals in an open way. The problem of reducing the cost of transporting 1 ton of rock mass and increasing the efficiency of these machines is being solved. The article develops an expert system for dispatching mining vehicles with a subsystem for selecting their innovative appearance with the ability to control their operational parameters, taking into account the stochastic conditions of the developed sections of the rock mass. The mathematical model for constructing the prospective appearance of a mining and transport machine, based on its functional and economic assessment, is reduced to solving the problem of optimizing the generalized criterion of the required efficiency. As an example of private indicators of their effectiveness in operation, there is an expert analysis of the evaluation of solution options, for example, structural-kinematic and operational parameters of these machines, etc. Innovative designs of a skip body of any size of its carrying capacity of single-rope and multi-rope steeply inclined skip hoists for highly profitable mining in quarries are substantiated. unlimited values of their depth and annual productivity. In the proposed study, the values of the forces of resistance to the destruction of a section of a rock mass, obtained by analytical and experimental methods, are refined by finding the optimal Kalman coefficient, which increases the efficiency of using mining and transport machines. The proposed methods provide the creation of innovative mining and transport machines with the ability to control their operational parameters, taking into account the stochastic conditions of the developed section of the rock mass
Comparative study of recovery parameters of Desflurane and Sevoflurane in functional endoscopic sinus surgery
Authors: Uppala Harish , Kumar Mamidi Ajay , Ansari Mohd Moazzam Mohiuddin 
Published: May 2022

Numerous inhalant anaesthetics are often utilised to provide the optimal operating field required for successful endoscopic sinus surgery (ESS). Modern inhaled anaesthetics such as Sevoflurane and Desflurane enable rapid induction and recovery because to their low blood-gas partition coefficients.
The aim: The goal of this study is to compare desflurane with sevoflurane's recovery qualities after functional endoscopic sinus surgery.
Materials and methods: The present study was a prospective, randomised, comparative clinical trial that included participants scheduled to have functional endoscopic sinus surgery. The study included 60 ASA I and II patients scheduled for FESS under general anaesthesia and divided them into two groups of 30 each: group D (Desflurane) and group S (Sevoflurane).
Results: There was no statistically significant difference in the age, gender, ASA grade, or mean weight distributions between the two groups (p>0.05). There was no statistically significant difference in the mean length of operation or anaesthesia between the two groups. Hemodynamic variables did not alter much. Time in minutes for eye opening (p<0.001) was significantly shorter in group D (Desflurane) than in group S (Sevoflurane). Time in minutes for extubation (p<0.001) was significantly shorter in group D (Desflurane) 6.53±1.14 than in group S (Sevoflurane) 9.37±1.30. Time in minutes for obeying commands (p<0.001) was significantly shorter in group D (Desflurane) 7.87±1.11 than in group S (Sevoflurane) 11.33±1.51.
Conclusion: In patients receiving FESS time taken for eye opening, extubation and time taken for obeying commands from termination of anesthetic is significantly shorter with desflurane (group D) when compared with sevoflurane (group S). So desflurane was linked to a quicker early recovery than sevoflurane.
B-mode ultrasonography of herniated cervical discs in young people
Authors: Abdullaiev Ruslan , Voronzhev Igor 
Published: May 2022

The aim: to evaluate the possibilities of ultrasonography in the diagnosis of herniated cervical intervertebral discs in young people.
Material and methods: an analysis of the results of USG in 29 patients with cervical IVD hernia revealed by MRI from 123 patients aged 18–44 years, with complaints of neck pain of varying intensity, duration, and irradiation. 23 (79.3 %) patients had clinical signs of cervical radiculopathy. The results of the ultrasonography (USG) were compared with MRI. USG was conducted on a Philips HD 11XE scanner using a 4–9 MHz frequency transducer; MRI – General Electric, Signa HDI, 1.5T.
Results: in 13 (44.8±9.2 %) cases the hernia was registered in the C5-C6 disk, in 12 (41.4±9.0 %) – in the C4-C5 disk, in 2 (6.9±4.7 %) – in the disk C3-C4 and in 2 (6.9±4.7 %) – in the disk C6-C7. In discs C5-C6 and C4-C5 hernia was formed significantly (p<0.01 and p<0.001) more often than in discs C2-C3 and C6-C7. Paramedian hernia was diagnosed in 13 (44.8±9.2 %) cases, posterior – in 12 (41.4±9.1 %), median – in 4 (13.8±6.4 %). Paramedian and posterolateral hernias were registered significantly more often than median (p<0.01 and p<0.05).
Conclusions: A direct sign of a herniated cervical intervertebral disc is its uneven protrusion with a discontinuous image of the fibrous ring into the lumen of the spinal canal and spinal nerve canal more than 4 mm. An indirect sign of a herniated cervical intervertebral disc is a local deformation of the anterior epidural space with the absence of its visualization. Ultrasonography is a reliable method for diagnosing herniated cervical intervertebral discs, both in segments and inside the spinal canal. The method can be used to find out the causes of neck pain in young people
Advanced research for physico-chemical properties and parameters of toxicity piperazinium 2-((5-(furan-2-YL)-4-phenyl-4H-1,2,4-triazol-3-YL)THIO)acetate
Authors: Karpenko Yuriy , Hunchak Yuliia , Gutyj Bohdan , Hunchak Alla , Parchenko Maryna , Parchenko Volodymyr 
Published: May 2022

The achievements of modern domestic pharmacy clearly prove the prospects of searching for biologically active molecules among 1,2,4-triazole derivatives.
The aim of our work was to predict the safest compound, select it and unambiguously prove the structure of a new promising molecule, to investigate some parameters of its toxicity.
Materials and methods. X-ray diffraction analysis was performed in the laboratory of the Institute of Single Crystals of the National Academy of Sciences of Ukraine (Kharkiv). Computer methods were used to build “structure – toxicity” models and predict LD50 using already created models GUSAR, TEST. The degree of toxicity (DL50) and the approximate doses for the subacute experiment were determined by studying the acute toxicity of the test chemical and the injectable solution based on it. Determination of acute toxicity parameters by intragastric administration was performed on white rats, aged 3-4 months, body weight 200-220 g.
Results. Due to the study of the toxicity of 1,2,4-triazole derivatives by non-experimental methods using GUSAR and TEST models, it was found that the test compounds could be classified as low-toxic substances.
The compound is an organic salt that exists in the crystal as a solvate with one molecule of methanol and two molecules of water. When studying the structure of the crystal, it was found that the crystal is in the pinacoidal triclinic syngony.
According to the results of the studies, it was found that after a single intragastric administration of the compound in doses of 1000, 3000 and 5000 mg / kg, all animals remained alive for 14 days. The basis of the biological action of chemical compounds is the violation of several biochemical processes. We found that the studied blood constants, on the background of the use of newly synthesized substance, underwent some changes.
Conclusions. According to the assessment of the toxicity of the drug “VPK-434” when administered intragastrically to laboratory rats, it was found that in accordance with SOU 85.2-37-736: 2011 the test substance belongs to the IV class of toxicity (low toxicity). It was found that the average lethal dose of DL50 of the test substance by intramuscular administration to rats is 1666.66 mg / kg body weight. It was studied that some abnormalities in the hematopoietic system (increase in the number of leukocytes, including eosinophils), liver and kidney function (increased activity of transaminases, decreased serum concentrations of total protein, urea and creatinine) and changes in mineral metabolism of experimental animals groups, on the background of receiving 10 multiple doses of the study drug, was short-term, and the restoration of the functional state of the body of rats could be said as early as 4-5 days after discontinuation of the drug into their body
Possible effects of the exposure to ionizing radiation on the patients recovered from COVID-19
Authors: Domina Emiliia 
Published: May 2022

The aim. To conduct an analytical literature review on the possible impact of SARS-CoV-2 on the radiosensitivity of the human body and justify the relevance of radiobiological research in this area.
Materials and methods. Analysis of data from biological dosimetry / indication of radiation lesions of human peripheral blood T-lymphocyte chromosomes under medical irradiation for comparison with radiosensitivity in the patients recovered from COVID-19 (Scopus International Scientific Metric Database, IAEA guidelines, 2011).
Results. With the ongoing COVID-19 pandemic, forecasting and clarifying of the mechanisms of distant effects resulting from interactions between ionizing radiation and the SARS-CoV-2 virus play an important role. The difficulty in solving this problem is caused by the fact that the global science has no exhaustive information on the possible influence of this virus on radiation-induced effects. The attention of the professional community is drawn to the possible impact of SARS-CoV-2 on the radiosensitivity of the body of patients recovered from COVID-19 and a hypothesis is first proposed regarding the mechanism on how to increase it based on the development of systemic long-term inflammation. Therefore, clinical trials of low-dose radiotherapy for the treatment of COVID-19-related pneumonia involve preliminary radiobiological studies to answer the following question: does the SARS-CoV-2 virus affect the radiosensitivity of the human body? Long-term experience of the author of this paper in biodosimetric (cytogenetic) studies allows her to recommend the peripheral blood lymphocyte test system with chromosome aberration’s analysis as the most radiosensitive cell model.
Conclusions. Clinical trials of low-dose radiotherapy for the treatment of COVID-19 pneumonia involve a preliminary radiobiological study to answer the following question: does the SARS-CoV-2 virus affect the radiosensitivity of the human body? The most optimal approach for the solution of this problem is the use of test-system of human peripheral blood lymphocytes’ culture with the subsequent cytogenetic analysis. It will allow investigating changes in the “dose-effect” “cell cycle stage-effect” dependencies, as well as changes in individual radiosensitivity under the influence of SARS-CoV-2 virus
Urogenital infections of women of reproductive age caused by conditionally pathogenic microorganisms on the background of tobacco smoking
Authors: Starishko Oksana , Turytska Tetiana , Ovcharenko Anastasia 
Published: May 2022

The aim: to study changes in the microbiota of the urogenital tract of women of reproductive age in the Dnipro region, which is caused by conditionally pathogenic microorganisms on the background of smoking.
Material and methods: biomaterial of patients (scraping from the urogenital tract) who applied to the Center for Laboratory Medicine PE “VIS-MEDIC” in Dnipro region. We analyzed the components of the microbiota of the vagina of women of the surveyed groups (sign of age and smoking) in the period from 2018 to 2021. For the use in an analysis, microbiota data were obtained using the test system Femoflor Screen.
Results. Analysis of the results of the study revealed the dependence of the composition of the microbiota of the reproductive tract of women on the use of tobacco products. An increase in indicators for conditionally pathogenic microorganisms was shown. The rate of detection of elevated levels of M. hominis in samples of biological material varied between 6-8 % but was not recorded in all study groups of women. There was also an increase in the frequency of detection of elevated levels of U. urealyticum, U. parvum in samples of biological material, the values of which ranged from 9 to 50 %.
Conclusions. The obtained data allowed to assess the effect of tobacco on the composition of the microbiota of the urogenital tract of women and made it possible to use them in measures of social and preventive work, as an indisputable fact to quit smoking. Therefore, there is a need for further research to establish the role of microorganisms involved in restoring the composition of the microbiota after inflammatory processes in women who use and do not use tobacco products.
The results may be relevant for the diagnosis of inflammatory diseases, processes caused by opportunistic pathogens of the urogenital tract of women of reproductive age, potentially dangerous occurrence and development of infertility and the basis for social and preventive work among women on the background of smoking
Views on Scientific Research Methods: A Study of North Indian Engineering Faculty Members
Authors: A. K. Malik Manusmriti Sharma, 
Published: May 2022

Scientific research is a significant component in the field of education. It is a systematic effort not only to get proficiency in teaching but also to stimulate independent search for new knowledge, to unravel scientific issues and to identify how to study the information. This study aimed to investigate the views of North Indian engineering faculty members on the scientific research methods (SRM). The research data was collected through a structured questionnaire and interviews. The faculty members were asked questions about scientific research methods and their opinion about how to improve the effectiveness of engineering faculty in teaching and research. To this aim, the main effects of the scientific research methods on academics and research have been studied. The research work data was collected from more than five hundred faculty members and was analysed with the descriptive method. The findings indicate a positive relationship between teaching pedagogy and scientific research methods. The results also revealed that the engineering faculty members lacked knowledge about scientific research methods which further impedes the systematic teaching-learning process.
THE PREVALENCE OF DENTAL DISEASES AND FEATURES OF HEMATOLOGICAL PARAMETERS IN CANCER PATIENTS
Authors: Uspenskaya Ol'ga , Fadeeva Irina , Kokobelyan Diana , Budylin Mikhail 
Published: May 2022

Subject. Oncological diseases are one of the leading causes of medical losses worldwide, so early and timely diagnosis of oncological diseases remains relevant to this day. Most patients have multiple comorbidities. It is known that all pathological processes occurring in the human body cannot but affect the state of the oral cavity. Therefore, the study of common pathogenetic links in the development of these diseases, including cancer, and the need to optimize the methods of their diagnosis, complex treatment and prevention continue to be relevant.
Objectives. To study the features of the dental status and analysis of blood parameters in patients with extraoral pathology.
Methodology. To carry out the study, a dental examination was carried out, including an assessment of the condition of the oral mucosa and periodontium, screening by diascopy and APS diagnostics, determination of KPU indices, oral hygiene index OHI-S, PMA, CPITN. All subjects underwent a clinical and biochemical blood test with further research.
Results. The study revealed the predominance of certain types of dental diseases in patients with different localization of oncopathology. According to the results of the general and biochemical blood tests, changes were noted that are characteristic of latent iron deficiency and anemia, as well as liver pathology.
Conclusion. The study revealed a high intensity of dental caries in cancer patients. A high prevalence of periodontal disease has been noted. Of the dental diseases in cancer patients, hyperplasia of the filiform papillae, geographic tongue, and candidiasis were most often diagnosed. Analysis of blood parameters revealed the presence of a latent iron deficiency and impaired hemoglobin formation. Changes in biochemical parameters of blood, characteristic of the pathological state of liver tissues, were also noted.
COMPARATIVE ANALYSIS OF INNOVATIVE METHODS OF TREATMENT OF INITIAL CARIES
Authors: Dem'yanenko Svetlana , Duryagina Larisa , Prijma Natalia , Degtyareva Ludmila , Kozub Daria , Samokish Yulia 
Published: May 2022

Objectives. Remineralizing therapy is widely used in the treatment of acute initial caries. However, when the protein matrix of the enamel is destroyed in the area of the initial caries, remineralizing therapy turns out to be ineffective, which requires the choice of a different method of treatment. One of these methods is the Icon (Infiltration Concept) enamel infiltration method, which allows to preserve the natural healthy tooth tissues as much as possible and restore the enamel affected by caries.
Purpose — to analyze the comparative study of the clinical efficacy of the Icon infiltration method and the deep fluoridation method in the treatment of acute initial caries.
Methodology. The article presents the results of studying the clinical efficacy of the Icon infiltration method and the deep fluoridation method in the treatment of acute initial caries of 89 teeth in 50 students of the Medical Academy. S.I. Georgievsky at the age of 18–24. Paraclinical indices were studied: hygiene index (OHI-S), the intensity of dental caries damage (CPU of teeth, CPU of cavities), means of individual hygiene for the oral cavity were selected, general remineralizing treatment was prescribed. To assess the dynamics of treatment, patients were divided into three groups of groups, taking into account the therapy.
Results. Clinical application of the Icon infiltration method in the treatment of initial caries made it possible to achieve stabilization of the pathological process and restoration of enamel in 100% of cases — there was a complete disappearance of the focus of demineralization in all teeth, elimination of clinical manifestations of acute initial caries, reduction of the degree of demineralization revealed by vital staining by 83.6%.
Conclusions. Our positive results allow us to recommend a wider clinical application of the Icon infiltration method in order to restore enamel in the treatment of initial caries.
DYNAMICS OF RHEOLOGICAL PROPERTIES OF SALIVA IN ONCOPATIENTS WITH ORAL MUCOSITOIS IN THE PROCESS OF TREATMENT
Authors: Romanenko Inessa , Arakelyan Kristina 
Published: May 2022

Oral mucosal cancer is diagnosed worldwide. There are approximately 350,000 patients annually and it accounts for 5% of all malignant neoplasms detected in Europe and the USA. More than 60% of patients with initial treatment in medical institutions are assigned III–IV stage, which requires combined or complex treatment. Under the influence of chemo-radiation therapy, the salivary glands are affected and the physico-chemical properties of saliva change: viscosity, pH, salivation rate, etc.
The study involved 89 people from the V.M. Efetov Crimean Republican Oncological Clinical Dispensary with a diagnosis of cancer of the oral mucosa, who, depending on the type of treatment (developed or traditional), were divided into two groups: the main one – using Laetrile in the form of rinses or oral baths for 8–14 days and the control – antitumor treatment according to the protocol (0.06% chlorhexidine solution, ointments for the elements of the lesion – levomycol, vaseline, pharmacy lotion and decoctions of chamomile and sage herbs).
A clinical and laboratory evaluation of the salivation function was performed: the volume, salivation rate and relative viscosity of the oral fluid were studied. Oral fluid after irritation of the tongue with a food irritant (0.5% citric acid) was collected in a graduated tube for 5–10 minutes and the volume was determined. The salivation rate and saliva viscosity were determined using an Oswald’s viscometer using the technique of T.L. Redinova (1986).
The features of salivation dysfunction in oncopatients receiving chemo-radiation therapy of the oral cavity are a decrease in volume (0.14 ± 0.01 ml) and velocity (0.42 ± 0.018 ml/min), as well as an increase in viscosity (7.42 ± 0.25 p.u.) saliva. The use of Laetrile for 10–14 days from the beginning of the course of chemo-radiation therapy can significantly prevent a decrease in the volume and increase in the viscosity of saliva and minimize the associated decrease in quality of life.
Effect of Continuous Nursing Model Based on WeChat Public Health Education on Self-Management Level and Treatment Compliance of Stroke Patients
Authors: Tan Chunyan , Qin Yan , Liao Chunlian , Liu Jihong , Peng Qian , Jiang Wei , Gan Xiuni 
Published: May 2022

Background: To analyze the effect of continuous nursing model based on WeChat public health education on self-management level and treatment compliance of stroke patients.
Methods: Overall, 98 stroke patients admitted to the Second Affiliated Hospital of Chongqing Medical University, ChongQing,400000,China from Feb 2018 to Feb 2019 were enrolled as the research objects. They were randomly and equally divided into experimental group and control group. The control group received routine nursing management model while the experimental group received continuous nursing model based on WeChat public health education to compare the self-management level, treatment compliance, life quality and other indexes between the two groups.
Results: The overall self-management level in the experimental group was significantly higher than that in the control group (P<0.05). The life quality scores in both groups after nursing intervention increased, and the scores in the experimental group after nursing intervention were significantly higher than those in the control group (P<0.001). The total treatment compliance rate in the experimental group was higher than that in the control group (P=0.001). After nursing intervention, the readmission rate and complication rate in the experimental group were significantly lower than those in the control group (P<0.05).
Conclusion: The implementation of continuous nursing model based on WeChat public health education for stroke patients can significantly enhance the self-management level, improve the cognitive level on stroke related-health knowledge, improve treatment compliance of patients in the nursing process, promote their physical and mental health, improve the life quality and effectively reduce the complication rate and readmission rate.