bluuebunny/crossref_metadata_2025_split huggingface dataset:
4. Democratising Participatory Research
Authors: Martinez-Vargas Carmen 
Published: January 2022

The fourth chapter asks if, as the literature claims, the colonial challenge is central for participatory practices, how can we resolve the limitations and controversies highlighted in the previous chapter? Martinez-Vargas introduces the Capabilities Approach, linking its foundational elements with decolonial debates. This section illustrates the current commonalities between both positions and the potential of the Capabilities Approach to fill some of the gaps in the field of participatory practices. To this end, the chapter uses an open-ended version of the Capabilities Approach defended by Amartya Sen (1999; 2011) to understand the multiple ways of living beyond the Western lifestyle. This provides a theoretical foundation capable of accommodating different lifestyles around the world that do not necessarily fit into the hegemonic capitalist/neoliberal/patriarchal and heteronormative perspective.
This chapter explores the tensions and limitations of research in the academic context, and the challenges of applying participatory research in higher education institutions. The text explores the practical differences between conventional research processes and fully participatory research processes. The chapter concludes by introducing Democratic Capabilities Research (DCR) through five open-ended principles that can accommodate the variety of practices needed to democratise participatory research from a decolonial capabilities perspective.
After this chapter, the reader will have a clear understanding of where decolonial participatory research stands. Moreover, the practitioner will uphold DCR—understanding its five constitutive elements—in order to be able to put them into practice.
Spectrum of intimate partner violence in patients with psychiatric illness–From victimization to perpetration
Authors: Gupta Geetanjali , Sachdeva Ankur , Kumar Manoj , Singh Mitasha 
Published: January 2022

Purpose Persons with psychiatric illness are vulnerable to be the victims of intimate partner violence (IPV) and at risk of perpetrating IPV. Objectives To estimate the prevalence and association of IPV in patients with psychiatric disorders, both as victims and as perpetrators. Methodology We conducted a questionnaire based, cross-sectional study using systematic random sampling at psychiatric Outpatient Department (OPD) in a tertiary care hospital, in Haryana, India. A total of 500 participants diagnosed with psychiatric disorder were assessed using Operational WHO Criteria for IPV Victimization assessment and IPV Perpetration Assessment scale by Rhodes et al. Results The prevalence of IPV victimization was 16% during the last year and 26% during lifetime. IPV victimization was found significantly more in females (especially sexual), young and unemployed participants, during the initial 10 years of marriage and 10 years of the illness. Sexual IPV was the most common. The prevalence of IPV perpetration by the participants was 6% during last year and 10.6% in lifetime. Perpetrators were more likely to be males of higher age (40–50 years), unemployed, having lower income, belonging to joint family, and residing in rural areas. Diagnosis of a psychiatric illness, especially psychosis increased chances of perpetration. As the duration of illness increased, prevalence of IPV perpetration increased. Conclusion Intimate partner violence among persons with psychiatric disorders is common and they are more vulnerable to being victims of IPV, rather than perpetrating IPV. Vulnerability and risk factors for IPV should be taken into account and optimized strategies should be devised for prevention.
‘It was like an airbag, it cushioned the blow’: A multi-site qualitative study of bereaved parents’ experiences of using cooling facilities
Authors: Hackett Julia , Heavey Emily , Beresford Bryony 
Published: January 2022

Background: Evidence on the benefits to parents of spending time with their child in the hours after their death means this is now routine practice. UK children’s hospices offer parents the opportunity to extend this period by using cooling facilities (i.e. cooled ‘bedrooms’; cooling blankets/mattresses) to slow deterioration. Aim: To explore parents’ experiences of using cooling facilities and beliefs about how it shaped experiences of the very early days of bereavement, and on-going grieving processes. Methods: Multi-site study involving in-depth interviews with parents bereaved in the previous 3 years. Grief theories informed data analysis, which employed narrative and thematic approaches. Eight hospices supported recruitment. Results: Twenty-two mothers and eight fathers were recruited, representing 25% of families approached. Duration of use of a cooling facility varied, as did the amount of time spent with the child. All parents treasured this period, valuing the way it eased separation from their child and gave some control over when this happened. They believed all bereaved parents should have the opportunity to use a cooling facility. Using a cooling facility supported parents’ engagement with grief tasks including acceptance of loss, processing emotional pain and facing changes to their lives brought about by their child’s death. Memories and mementoes created during this period served to support on-going connections with the child. Parents who used a cooling facility at a hospice reported benefits of the setting itself. Conclusions: As well as easing the very early days of loss, use of cooling facilities may influence longer-term bereavement outcomes.
Changes in the Synovial Fluid Cytokine Profile of the Knee Between an Acute Anterior Cruciate Ligament Injury and Surgical Reconstruction
Authors: Kingery Matthew T. , Anil Utkarsh , Berlinberg Elyse J. , Clair Andrew J. , Kenny Lena , Strauss Eric J. 
Published: January 2022

Background: Changes in the intra-articular inflammatory state during the immediate period after an acute anterior cruciate ligament (ACL) rupture are not well defined. Purpose: To evaluate changes in the concentration of select proinflammatory and anti-inflammatory synovial fluid cytokines during the interval between an ACL injury and surgical reconstruction. Study Design: Descriptive laboratory study. Methods: In patients with an acute ACL injury, a synovial fluid sample was obtained from the injured knee during the initial office visit within 2 weeks of the inciting traumatic event. An additional synovial fluid sample was collected at the time of ACL reconstruction just before the surgical incision. Synovial fluid samples from both the acute injury and the surgery time points were processed with a protease inhibitor, and the concentrations of 10 cytokines of interest were measured using a multiplex magnetic bead immunoassay. The primary outcome was the change in cytokine concentrations between time points. Results: A total of 20 patients with a mean age of 30.2 ± 8.3 years were included. The acute injury synovial fluid samples were collected at 6.6 ± 3.8 days after the injury. The surgical synovial fluid samples were collected at 31.6 ± 15.6 days after the acute injury samples. Based on a series of linear mixed-effects models to control for the effect of concomitant meniscal injuries and by-patient variability, there was a statistically significant increase in the concentrations of RANTES and bFGF and a statistically significant decrease in the concentrations of IL-6, MCP-1, MIP-1β, TIMP-1, IL-1Ra, and VEGF between time points. Conclusion: This study demonstrates the ongoing alterations in the intra-articular microenvironment during the initial inflammatory response in the acute postinjury period. We identified 6 synovial fluid cytokines that significantly decreased and 2 that significantly increased between the first clinical presentation shortly after the injury and the time of surgery 1 month later. Clinical Relevance: This study describes the molecular profile of the inflammatory changes between the time of an acute ACL injury and the time of surgical reconstruction 1 month later. A greater understanding of the acute inflammatory response within the knee may be helpful in identifying the optimal timing for a surgical intervention that balances the risk of chondral damage with the likelihood of successful, well-healed reconstruction.
Assessing design and manufacturing quality of tractor gearboxes by their vibration characteristics
Authors: Migal Vasiliy , Arhun Shchasiana , Shuliak Mykhailo , Hnatov Andrii , Trunova Iryna , Shevchenko Igor 
Published: January 2022

The paper deals with the development of a vibration-based technique for assessing quality and detecting design and manufacturing defects of tractor gearboxes. It highlights full-scale experimental studies of vibro-diagnostic characteristics of tractor gearboxes including carrying out vibration measurement and spectrum analysis; identifying statistical limit values of structural vibration parameters and their dependence on the technical condition of tractors; and comparing the vibration characteristics with acceptable vibrations which do not affect the acceleration of the process of tractor gearbox wear. All studies were conducted for tractor gearboxes of wheeled tractors T-150K, KhTZ-170, and T-17221 produced by Kharkiv Tractor Plant and equipped with identical tractor gearboxes of the same manufacturer. It has been determined that the vibration levels of gearboxes at the manufacturing stage exceed the acceptable vibrations by 10–30 dB. The main reason for the accelerated development of faults and decrease in the lifetime of most gearbox mechanisms is an increase in vibration loading by 2.5–31.6 times over the acceptable levels. The practical significance of the results obtained is in solving the problem of improving the design and manufacturing of tractor gearboxes T-150k through the use of the developed criteria for permissible vibration by methods of reducing the vibration level of detected defects. All the above mentioned makes it possible to create a complex of normative and technical, and methodological documentation to improve the reliability of tractors.
Assessment of Imatinib as a Primary Treatment of Chronic Myeloid Leukemia in Chronic Phase: a Cohort Study
Authors: Merin Dana , Krishna Akshaya , Jayakumar Sreelekshmi , Mahima A , Anila K N , Sidharthan Neeraj 
Published: January 2022

Purpose The study aimed to assess the effectiveness of Imatinib in chronic myeloid leukaemia (CML) in our hospital population. In addition to identify which brand of imatinib (Gleevec/Veenat) is cost effective for CML patients and to assess the possible adverse drug reactions during the treatment for chronic myeloid leukaemia. Methods A non-interventional (observational), both retrospective and prospective study was carried out in the department of Medical Oncology and Haematology of our hospital. A total of 152 patients were enrolled in the study. Patients who satisfied the inclusion and exclusion criteria were selected for the study. Results Evaluation of baseline characteristics of study population (n = 152) showed predominance of males (65.1%). The mean age was 49.80 ± 16.561 years. The overall clinical outcome of the sample population, BCR ABL value responses during 3,6 and 12 months are the main indicators for the prediction of outcome in CML -CP patients. Using Independent sample t test, it was found that the difference in response to Imatinib therapy during 3,6 & 12 months were statistically significant and showed a statistically significant difference between the good and adverse outcome (p < 0.001). Conclusion Our study concluded that Imatinib showed a benefit in treating the condition without any life-threatening adverse events and also the drug exhibits a complete haematological and optimal response based on European Leukaemia Net criteria during the period of study. From which, it can be concluded that imatinib appears to be a safe and well-tolerated treatment for the chronic-phase chronic myeloid leukaemia population.
Audio Diaries: A Novel Method for Water, Sanitation, and Hygiene-Related Maternal Stress Research
Authors: O’Reilly Kathleen , Ramanaik Satyanarayana , Story William T. , Gnanaselvam Nancy Angeline , Baker Kelly K. , Cunningham L. Troy , Mukherjee Aparna , Pujar Ashwini 
Published: January 2022

Previous studies have identified both physical and psychosocial forms of stress among newly married women due to inadequate water, sanitation, and hygiene (WASH) access. However, methodologies used to identify stress have relied on surveys and interviews, which have limitations for eliciting situated information regarding stress. Prior public health studies indicate that, together with other qualitative methods, audio diaries provide rich data sets of participants’ everyday practices, and their interactions with their physical and social environment. In this research, our interdisciplinary team collaborated to explore the feasibility of making audio diary recordings from prompts in a rural, Indian context where many women are illiterate. Three pregnant women living in rural Karnataka (India) were trained on the prompts and audio recorders, and were asked to make audio entries over two weeks. Midterm and exit interviews were used to ascertain women’s thoughts and experiences making audio diary entries. Each woman successfully recorded, on average, 27 minutes per week, demonstrating the feasibility of audio diaries in rural India. While the recruitment and training process was labor intensive and required follow-up visits, trust-building between participants and researchers over time facilitated discussions about the contextual and experiential details of making recordings that will improve data collection through this method. We concluded that when used with other qualitative methods, audio diaries offer a unique opportunity to collect participants’ practices, feelings, reflections, and interactions with their physical and social environment in real time.
Flavonoid intakes inversely associate with COPD in smokers
Authors: Bondonno Nicola P. , Parmenter Benjamin H. , Dalgaard Frederik , Murray Kevin , Rasmussen Daniel Bech , Kyrø Cecilie , Cassidy Aedin , Bondonno Catherine P. , Lewis Joshua R. , Croft Kevin D. , Gislason Gunnar , Scalbert Augustin , Tjønneland Anne , Overvad Kim , Olsen Anja , Hodgson Jonathan M. 
Published: January 2022

IntroductionHigher flavonoid intakes are beneficially associated with pulmonary function parameters; however, their association with chronic obstructive pulmonary disease (COPD) is unknown. This study aimed to examine associations between intakes of 1) total flavonoids, 2) flavonoid subclasses and 3) major flavonoid compounds with incident COPD in participants from the Danish Diet, Cancer and Health study.MethodsThis prospective cohort included 55 413 men and women without COPD, aged 50–65 years at recruitment. Habitual flavonoid intakes at baseline were estimated from a food frequency questionnaire using Phenol-Explorer. Danish nationwide registers were used to identify incident cases of COPD. Associations were modelled using restricted cubic splines within Cox proportional hazards models.ResultsDuring 23 years of follow-up, 5557 participants were diagnosed with COPD. Of these, 4013 were current smokers, 1062 were former smokers and 482 were never-smokers. After multivariable adjustments, participants with the highest total flavonoid intakes had a 20% lower risk of COPD than those with the lowest intakes (quintile 5versusquintile 1: HR 0.80, 95% CI 0.74–0.87); a 6–22% lower risk was observed for each flavonoid subclass. The inverse association between total flavonoid intake and COPD was present in both men and women but only in current smokers (HR 0.77, 95% CI 0.70–0.84) and former smokers (HR 0.82, 95% CI 0.69–0.97), not never-smokers. Furthermore, higher flavonoid intakes appeared to lessen, but not negate, the higher risk of COPD associated with smoking intensity.ConclusionDietary flavonoids may be important for partially mitigating the risk of smoking-related COPD. However, smoking cessation should remain the highest priority.
Analysis of risk factors for early-onset ventilator-associated pneumonia in a neurosurgical intensive care unit
Authors: Teng Guojie , Wang Ning , Nie Xiuhong , Zhang Lin , Liu Hongjun 
Published: January 2022

Abstract
Background
Ventilator-associated pneumonia (VAP) is a severe infection among patients in the neurosurgery intensive care unit (NICU).

Methods
We retrospectively evaluated risk factors for early-onset ventilator-associated pneumonia (EOVAP) from January 2019 to December 2019 at a NICU. A total of 89 NICU patients who were intubated within 48 h of onset and whose mechanical ventilation time was at least 7 days were enrolled. We evaluated EOVAP that occurred within the first 7 days after the onset of mechanical ventilation. The enrolled patients had no history of chronic lung disease and no clinical manifestations of infection before intubation. Clinical data of patients were recorded, and the incidence of and risk factors for EOVAP were analyzed. Patients were also grouped by age (≥ 65 vs. < 65 years) and whether they had received hypothermia treatment or not.

Results
Among 89 mechanically ventilated patients (49 men and 40 women; the mean age ± SD was 60.1 ± 14.3 years), 40 patients (44.9%) developed EOVAP within 7 days and 14 patients (15.7%) had a multidrug resistant bacterial infection. Binary logistic regression analysis indicated that older age (≥ 65 years) (odds ratio [OR]:3.53, 95% confidence interval [CI]:1.27–9.79, P = 0.015) and therapeutic hypothermia (OR:3.68, CI:1.10–12.31, p = 0.034) were independent predictors of EOVAP. Levels of peripheral blood leukocytes, neutrophils and platelets were lower in the therapeutic hypothermia group than those who did not receive hypothermia treatment.

Conclusions
This study found that older age (≥ 65 years) and therapeutic hypothermia were independently associated with the risk of EOVAP in NICU patients.
Deep learning identified glioblastoma subtypes based on internal genomic expression ranks
Authors: Mao Xing-gang , Xue Xiao-yan , Wang Ling , Lin Wei , Zhang Xiang 
Published: January 2022

Abstract
Background
Glioblastoma (GBM) can be divided into subtypes according to their genomic features, including Proneural (PN), Neural (NE), Classical (CL) and Mesenchymal (ME). However, it is a difficult task to unify various genomic expression profiles which were standardized with various procedures from different studies and to manually classify a given GBM sample into a subtype.

Methods
An algorithm was developed to unify the genomic profiles of GBM samples into a standardized normal distribution (SND), based on their internal expression ranks. Deep neural networks (DNN) and convolutional DNN (CDNN) models were trained on original and SND data. In addition, expanded SND data by combining various The Cancer Genome Atlas (TCGA) datasets were used to improve the robustness and generalization capacity of the CDNN models.

Results
The SND data kept unimodal distribution similar to their original data, and also kept the internal expression ranks of all genes for each sample. CDNN models trained on the SND data showed significantly higher accuracy compared to DNN and CDNN models trained on primary expression data. Interestingly, the CDNN models classified the NE subtype with the lowest accuracy in the GBM datasets, expanded datasets and in IDH wide type GBMs, consistent with the recent studies that NE subtype should be excluded. Furthermore, the CDNN models also recognized independent GBM datasets, even with small set of genomic expressions.

Conclusions
The GBM expression profiles can be transformed into unified SND data, which can be used to train CDNN models with high accuracy and generalization capacity. These models suggested NE subtype may be not compatible with the 4 subtypes classification system.
Effect of perinatal depression on birth and infant health outcomes: a systematic review and meta-analysis of observational studies from Africa
Authors: Dadi Abel Fekadu , Akalu Temesgen Yihunie , Wolde Haileab Fekadu , Baraki Adhanom Gebreegziabher 
Published: January 2022

Abstract
Background
Antenatal depression is associated with intrauterine growth retardation, preterm birth, and low birth weight. Infants born to mothers with postnatal depression also may suffer from malnutrition and other health problems. Even though there are few single studies conducted so far, a systematic review of these studies is highly important to highlight the effect of antenatal and perinatal depression on adverse birth and infant health outcomes in Africa.

Methods
We used the Preferred Report Items for Systematic Review and Meta-analysis (PRISMA) when conducting this study. Databases like CINAHL (EBSCO), MEDLINE (via Ovid and PubMed), PsycINFO, Emcare, Psychiatry Online, and Scopus were searched. In addition, Google Scholar and references from a list of eligible studies were explored. We included good quality observational studies based on Newcastle Ottawa Scale which are published in the English language between 2007 and 2018. Heterogeneity and publication bias were assessed. Meta-analysis with a random effect model was employed to determine the pooled effect sizes with a 95% confidence interval. The review protocol is registered in PROSPERO (CRD42018106714).

Result
We found three studies (1511 participants) and 11 studies (22,254 participants) conducted on the effect of antenatal depression on birth outcomes and perinatal depression on adverse infant health outcomes, respectively. The overall risk of having adverse birth outcomes was 2.26 (95% CI: 1.43, 3.58) times higher among pregnant mothers with depression. The risk of preterm birth and low birth weight was 1.77 (95% CI: 1.03, 3.04) and 2.98 (95% CI: 1.60, 5.55) respectively. Similarly, the risk of having adverse infant health outcomes namely malnutrition and febrile illness was 1.61 (95% CI: 1.34, 1.95) times higher among mothers who had perinatal depression.

Conclusions
We have found a significant association between antenatal depression and adverse birth outcomes, low birth weight and preterm birth. Similarly, a significant effect of perinatal depression on adverse infant health outcomes namely, malnutrition, and febrile illnesses was observed. The findings highlight that it is time to integrate mental health services with routine maternal health care services to improve birth outcomes and reduce infant morbidity.