bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambiente Escolar como Suporte para a Prevenção ao uso de drogas: uma Revisão Narrativa
Authors: Varela Lopes Isadora , Silva Pires Anna Priscyla , Pinheiro Araújo Bárbara , Lyra de Souza Bruna Vitória , Alves de Morais Samuel , Oliveira Pachú Clésia 
Published: January 2025

A inserção do ambiente escolar como suporte para prevenção ao uso de drogas se revela como fator importante para qualidade de vida dos estudantes e da sociedade. As intervenções acerca do controle da dependência química de substâncias psicoativas se apresentam como fundamentais na prevenção ao uso de drogas entre estudantes, uma vez que alguns fatores como o uso frequente e precoce de substâncias psicoativas podem gerar danos à saúde física e mental desses indivíduos. Objetivou-se analisar o ambiente escolar como suporte para prevenção ao uso de drogas por meio de uma revisão narrativa. A presente revisão narrativa acerca do ambiente escolar como suporte para prevenção ao uso de drogas foi realizada durante os meses de junho e julho de 2023, utilizando bancos os dados Google Acadêmico e o Periódico CAPES, tendo sido selecionados 32 artigos para integrar a pesquisa. Os resultados obtidos demonstram que a escola representa um espaço fundamental para promoção de intervenções que discutam acerca da prevenção ao uso de drogas. Nesse sentido, o ambiente escolar, bem como os profissionais que atuam nesse campo, apresentam-se como agentes na promoção à qualidade de vida e saúde dos estudantes. Portanto, na promoção de ações que reflitam acerca da utilização de substâncias psicoativas e as consequências geradas pelo uso. Assim, faz-se necessário a participação de mais escolas e profissionais que promovam ações a respeito da temática, com o intuito de promover a qualidade de vida, a saúde e o controle da dependência química.

Palavras-chave: Escolas; Prevenção ao uso de drogas; Substâncias psicoativas.
Image Findings from Dual-phase Computed Tomography Pulmonary Angiography for Diagnosing Tuberculosis-associated Fibrosing Mediastinitis
Authors: Zhang Mengdi , Bu Chao , Jiang Kaiyu , Long Xiaozhou , Sun Zhonghua , Cao Yunshan , Li Yu 
Published: January 2025

Objective:
Fibrosing mediastinitis (FM) is a rare and benign disease affecting the mediastinum and often causes pulmonary hypertension (PH). Timely
diagnosis of PH caused by FM is clinically important to mitigate complications such as right heart failure in affected individuals. This retrospective
study aimed to analyze the CT imaging characteristics of TB-related FM in patients with tuberculosis (TB). Additionally, the study investigates the
underlying reasons contributing to the manifestation of symptoms.

Methods:
From April 2007 to October 2020, high-resolution CT (HRCT) and dual-phase CT pulmonary angiography images of 64 patients with suspected
FM diagnosed with PH at a tertiary hospital were examined. The imaging characteristics of these CT scans were analyzed, with a specific focus on
the TB-FM involvement of the pulmonary veins, pulmonary arteries, and bronchi (down to the segment level).

Results:
HRCT imaging revealed that fibrous tissue inside the mediastinum exhibited minimal or negligible reinforcement in TB-FM and diffuse fibrous
infiltration in the mediastinum and hilar areas. Notably, segmental bronchial and pulmonary artery stenosis are more pronounced and frequently
co-occurring than lobe-level stenosis. Pulmonary venous stenosis developed outside the pericardium, whereas pulmonary artery stenosis occurred
outside the mediastinal pleura. Furthermore, no isolated FM involvement in pulmonary veins was noticed in this cohort.

Conclusion:
HRCT imaging of TB-related FM presents unique features in certain regions of the bronchi, pulmonary veins, and pulmonary arteries. Thus, it is
imperative to accurately identify fibrous tissue involvement in mediastinal lesions for proper diagnosis and management of TB-FM.
Clinical Features and Ultrasonographic Manifestations of Retroperitoneal Nerve Sheath Tumors
Authors: Wang Xiaoqing , Zhang Xiaoying , Zhao Rui , Liu Yan , Wen Chaoyang , Zheng Haining 
Published: January 2025

Objectives:
Retroperitoneal nerve sheath tumors are uncommon, representing a small fraction of all primary retroperitoneal neoplasms. Accurate differentiation
between benign and malignant forms is essential for optimal clinical management. This study assessed the clinical profiles and sonographic traits
of retroperitoneal nerve sheath tumors with the goal of enhancing diagnostic precision and developing therapeutic strategies.

Methods:
A retrospective analysis of patients diagnosed with benign retroperitoneal nerve sheath tumors who completed surgical treatment and underwent
ultrasound imaging was carried out. Tumors were classified based on sonographic features and blood flow characteristics as per Adler's grading
system. Statistical analysis was performed using SPSS 25.0. ROC curve analysis was carried out to determine the optimal diagnostic cutoff values.

Results:
A total of 49 patients were included in the study. There were no significant variances in age, gender, or tumor localization among the groups.
However, pronounced disparities were observed in tumor number, size, shape, definition of borders, internal echo pattern, structural composition,
presence of calcification, and blood flow signals between the classic and malignant groups. Notably, malignant tumors tended to manifest as larger
masses with indistinct margins and irregular shapes. The maximum tumor diameter emerged as a discriminating factor for malignancy, with a
diagnostic cutoff of 9.9 cm, yielding an AUC of 0.754 from the ROC curve analysis.

Conclusion:
This study outlines the distinctive clinical and sonographic features of retroperitoneal nerve sheath tumors, with a particular focus on malignant
subtypes. Ultrasonography emerges as a valuable diagnostic tool, contributing to the differentiation of tumor categories and potentially to the
development of targeted treatment strategies. The identification of specific sonographic markers may facilitate the early detection and detailed
characterization of these tumors, which could contribute to improved patient outcomes.
Editorial
Authors: Lucio Espino Patricia Daniela 
Published: January 2025

Editorial
Los cierres de año siempre son intensos, intentamos estirar el tiempo lo más que podemos para poder cerrar de la mejor forma; este año se dieron muchos cambios en nuestra querida UNAM, primero el cambio de rector, luego el nombramiento de nuestra querida Directora Sonia Venegas.
Empezamos esta trayectoria de las letras de Amicus Curiae con el número 26 que aperturó nuevas secciones y oportunidades para que nuestra comunidad universitaria pudiera tener un lugar de expresión jurídica.
La Coordinación Editorial cierra un año satisfecha con los cambios y nuevas formas de expresión, agradecemos a nuestros queridos lectores, pero sobre todo a nuestras talentosas plumas que hacen posibles cada número de nuestros artículos y de los números que publicamos.
Este número 26 de Amicus Curiae cierra un año de nuevos textos, por lo que sólo nos queda decir GRACIAS a todos los que han hecho posible los dos números con los que iniciamos esta trayectoria y con los que cerramos este año, así como agradecer a nuestra querida Directora y por supuesto a todo el equipo de la Coordinación Editorial, por hacer posible esta forma de expresión.
Les deseamos unas felices fiestas, nos vemos con más letras el próximo año.

Mtra. Patricia Daniela Lucio Espino
LA EDITORA
Diabetes, Subclinical Myocardial Injury or Stress, and Risk of Heart Failure Subtypes: The Jackson Heart Study
Authors: Kaze Arnaud D. , Bertoni Alain G. , Fox Ervin R. , Hall Michael E. , Mentz Robert J. , Berry Jarett D. , Echouffo-Tcheugui Justin B. 
Published: January 2025

OBJECTIVE
To assess the extent to which the concomitant presence of subclinical myocardial injury or stress and diabetes affects the risk of heart failure (HF) subtypes.

RESEARCH DESIGN AND METHODS
The Jackson Heart Study included Black adults, categorized based on diabetes status, high-sensitivity cardiac troponin I (hs-cTnI), and brain natriuretic peptide (BNP) levels. Subclinical myocardial injury was defined as hs-cTnI ≥4 ng/L in women and ≥6 ng/L in men, and subclinical myocardial stress as BNP ≥35 pg/mL. The study outcomes included incident HF, HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF).

RESULTS
Among 3,484 participants (mean age 54.6 years, 63.2% women, 22.3% with diabetes, 26.4% with subclinical myocardial injury, 9.4% with subclinical myocardial stress), 306 developed HF (151 HFpEF and 139 HFrEF) over 12 years. Compared with individuals with no diabetes and no subclinical myocardial injury at recruitment, participants with diabetes and subclinical myocardial injury had a higher HF risk (hazard ratio [HR] 3.84, 95% CI 2.60–5.66), HFpEF (HR 3.68, 95% CI 2.13–6.36), and HFrEF (HR 4.26, 95% CI 2.40–7.53). The HRs associated with the presence of diabetes and subclinical myocardial stress versus their joint absence were 4.03 (95% CI 2.50–6.51), 5.71 (95% CI 3.11–10.47), and 2.13 (95% CI 0.88–5.17) for HF, HFpEF, and HFrEF, respectively. There was no significant diabetes status and cardiac biomarkers interaction.

CONCLUSIONS
Both diabetes and subclinical myocardial damage significantly increase the risk of all HF types among Black individuals.
Pembelajaran Online Menggunakan Google Classroom di Masa Pandemi Covid -19 Terhadap Minat Belajar PJOK
Authors: Gunawan Komang Adi , Darmayasa I Putu , Semarayasa Ketut 
Published: January 2025

Penelitian ini bertujuan untuk menganalisis minat belajar peserta didik dalam mengikuti pembelajaran PJOK menggunakan google classroom di kelas. Penelitian ini adalah penelitian deskriptif kuantitatif dengan metode penelitian survei. Subjek penelitian berjumlah 66 orang. Teknik pengambilan subjek penelitian ini menggunakan seluruhan jumlah subjek sebanyak 66 orang. Data dianalisis menggunakan statistik deskriptif. Pengumpulan data menggunkan angket atau kuisioner melalui berbantuan google forms. Hasil penelitian ini adalah sebanyak 5 peserta didik masuk dalam kategori sangat berminat, 29 peserta didik masuk dalam kategori Berminat, 11 peserta didik masuk dalam kategori cukup berminat,15 peserta didik masuk dalam kategori kurang berminat dan 6 peserta didik masuk dalam kategori sangat kurang berminat. Berdasarkan Analisa data dan pembahasan, simpulan penelitian ini adalah pelaksanaan pembelajaran online menggunakan google classroom pada masa pandemi covid-19 terhadap minat belajar PJOK peserta didik kelas XI tahun pelajaran 2020/2021 tergolong cukup berminat dengan rata-rata skor mencapai 69,2. Implikasi penelitian ini adalah Pengaruh Lingkungan Belajar Online terhadap Minat Belajar dapat memiliki pengaruh signifikan terhadap minat belajar PJOK. Jika peserta didik merasa nyaman dan terlibat dalam proses pembelajaran online, minat belajar mereka dalam mata pelajaran PJOK mungkin meningkat. Hasil utama penelitian ini menunjukkan adanya pengaruh positif terhadap minat belajar mereka.
Permainan Bocce terhadap Kemampuan Motorik Anak Tuna Grahita Ringan pada Siswa SMP
Authors: Hidayat Rizky , Simatupang Nurhayati , Siregar Samsuddin , Kasih Indra , Valianto Budi , Zebua Syukur Damai 
Published: January 2025

Anak-anak dengan tuna grahita ringan seringkali menghadapi tantangan dalam perkembangan motorik halus dan kasar, yang dapat mempengaruhi aktivitas sehari-hari mereka serta interaksi sosial. Permainan bocce, yang mengharuskan pemain melempar bola dengan presisi dan kekuatan yang terukur, dapat membantu anak-anak ini dalam mengembangkan koordinasi tangan-mata, keseimbangan, serta keterampilan motorik kasar. Tujuan penelitian ini adalah untuk menganalisis pengaruh permainan bocce terhadap anak tuna grahita ringan pada siswa SMP. Jenis penelitian ini adalah penelitian eksperimen. Pada penilitian ini menggunakan teknik purposive sampling, pada semua siswa tunagrahita ringan di Sekolah Menenga Pertama. Data yang sudah didapatkan kemudian di analisis menggunakan aplikas komputer (statistikal package for social science) SPSS 20. Populasi dalam penelitian ini adalah siswa/siswa anak tunagrahita ringan di Sekolah Menengah Pertama. Berdasarkan data penelitian maka dapat disimpulkan bahwa terdapat pengaruh hasil treatment terhadap peningkatan kemampuan gerak motorik dasar anak tunagrahita ringan di Sekolah Menengah Pertama. Berdasarkan dari rumusan masalah dan hasil penelitian mengenai pengaruh permainan bocce terhadap kemampuan motorik anak tuna grahita ringan pada siswa menengah pertama, maka dapat ditarik simpulan bahwa terdapat pengaruh peningkatan kemampuan gerak motorik ringan pada siswa menengah pertama melalui permainan bocce. Implikasi penelitian ini dapat memberikan wawasan bagi pendidik dan terapis dalam merancang program pendidikan jasmani yang lebih inklusif dan efektif.
Model Pembelajaran Kooperatif Tipe Teams Games Tournament (TGT) Meningkatkan Hasil Belajar PJOK Materi Kebugaran Jasmani Peserta Didik Kelas VI Sekolah Dasar
Authors: I Kadek Gunawan  , N. P. D. Sucita Dartini  , Peby Gunarto  , I. W. Artanayasa  , I M  Satyawan  
Published: January 2025

Penelitian ini dilatarbelakangi oleh rendahnya tingkat partisipasi dan motivasi peserta didik dalam mengikuti pembelajaran PJOK. Penelitian ini bertujuan untuk menganalisis perbedaan hasil belajar PJOK antara siswa yang dibelajarkan melalui model pembelajaran kooperatif tipe Teams Games Tournament (TGT) dengan siswa yang dibelajarkan melalui model pembelajaran konvensional pada siswa kelas VI Sekolah Dasar. Penelitian ini menggunakan penelitian eksperimen dengan bentuk desain Pretest Postest Control Group Design. Populasi yang digunakan dalam penelitian ini adalah siswa kelas VI dari 6 sekolah dasar dengan jumlah siswa 155 orang. Sampel yang digunakan yaitu 2 sekolah sebagai kelas eksperimen dan kelas kontrol, pengambilan sampel menggunakan teknik cluster random sampling. Teknik yang digunakan untuk pengumpulan data adalah tes tulis untuk pengetahuan dan tes unjuk kerja untuk keterampilan. Teknik analisis data yang digunakan dalam penelitian ini adalah dengan menggunakan independent sample t test. Hasil penelitian menunjukkan nilai hasil belajar kelas eksperimen memperoleh nilai rata-rata 84,54 dan hasil belajar kelas kontrol mendapatkan nilai rata-rata 66,61, setelah diuji menggunakan independent sample t test hasil ini menunjukkan adanya perbedaan yang signifikan sehingga dapat disimpulkan terdapat pengaruh yang signifikan dari penerapan Model Pembelajaran Kooperatif Tipe Teams Games Tournament (TGT) terhadap hasil belajar PJOK siswa kelas VI Sekolah Dasar. Hasil penelitian ini berimplikasi dalam meningkatkan hasil belajar dan kebugaran jasmani siswa secara signifikan.
Afiksasi pada Cerpen “Odong-odong” karya Seno Gumira Ajidarma: Metode Linguistik Korpus
Authors: Dewi Tiara Tri , Liusti Siti Ainim 
Published: January 2025

This research aims to analyze the use of affixation, namely prefixes, suffixes, and confixes, in the corpus of Kompas short stories entitled “Odong-odong” by Arya Seno Gumira Ajidarma. Linguistic analysis shows that the structure of affixation in this short story reflects the relationship between words in the sentence as well as the context in which they are used. The method used in this research is qualitative descriptive corpus linguistic method by utilizing KORTARA (Korpus Nusantara) application. This application serves for data presentation, collection, and analysis. The data analyzed are words or sentences containing affixation in the short story “Odong-odong”. The data collection technique is done through documentation of corpus files in KORTARA application. For data analysis, computational linguistic analysis technique is used. The result shows the affixation process in the form of prefixes, suffixes, and confixes. In addition, this study also found that the affixation process functions to change the basic word group into a certain word group, making it easier for readers to analyze sentences based on context.
Anticancer Activity of Asiatic Acid from Centella Asiatica: A Comprehensive Systematic Review of In Vitro and In Vivo Studies
Authors: Ridho Fiki Muhammad , Fahrudin Panggih , Syachputra Andika Julyanto , Aruan Iren Angelia , Ulfah Kamailiya , Syahri Alfi 
Published: January 2025

Abstract—Centella asiatica, containing asiatic acid (AsA), represents one such candidate demonstrating promising anticancer effects. This study aims to comprehensively review the anticancer activity of AsA in published in vitro and in vivo studies. A systematic review method was employed and several databases, including Scopus, PubMed, ScienceDirect, and Google Scholar, were used to conduct a comprehensive and systematic search of the literature based in vitro and in vivo studies in November 2023 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Thirty-three articles were included, distributed across twenty-five in vitro studies, three in vivo studies, and five both in vitro and in vivo studies. Based on the findings in the reviewed articles, we report that AsA, a triterpene derived from C. asiatica, exhibits anticancer effects demonstrated both in various cancer cell lines and in cancer cell-induced animal model, through several mechanisms, including anti-inflammatory effects, antioxidant effects, inhibition of cell proliferation, inhibition of invasion and migration, and induction of apoptosis and autophagy. Conclusions based on findings in in vitro and in vivo studies, AsA has strong potential to be used and developed as an inhibitor of various types of cancer cells.
Keywords: anticancer, asiatic acid, cancer, centella asiatica, herbal

Abstrak—Centella asiatica, yang mengandung asam asiatik (AsA), mewakili salah satu kandidat yang menunjukkan efek antikanker yang menjanjikan. Penelitian ini bertujuan untuk meninjau secara komprehensif aktivitas antikanker AsA dalam studi in vitro dan in vivo. Metode yang digunakan adalah tinjauan sistematis pada beberapa basis data, termasuk Scopus, PubMed, ScienceDirect, dan Google Scholar, untuk melakukan pencarian literatur yang komprehensif dan sistematis berdasarkan studi in vitro dan in vivo yang dilakukan pada November 2023 dan mengikuti pedoman Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Tiga puluh tiga artikel diinklusikan, terdiri dari dua puluh lima studi in vitro, tiga studi in vivo, dan lima studi in vitro dan in vivo. Berdasarkan temuan dalam artikel yang ditinjau, kami melaporkan bahwa AsA, triterpen yang berasal dari C. asiatica, menunjukkan efek antikanker baik di berbagai sel kanker maupun pada model hewan yang diinduksi sel kanker, melalui beberapa mekanisme, termasuk efek antiinflamasi, efek antioksidan, penghambatan proliferasi sel, penghambatan invasi dan migrasi, serta induksi apoptosis dan autofagi. Kesimpulan berdasarkan temuan dalam studi in vitro dan in vivo, AsA memiliki potensi yang kuat untuk digunakan dan dikembangkan sebagai penghambat berbagai jenis sel kanker.
Kata kunci: antikanker, asam asiatik, kanker, centella asiatica, herbal
Feline urethral obstruction alters the urinary microbiota and comparison to oral, preputial, and rectal microbiotas
Authors: Lake Bathilda B. , McAdams Zachary L. , Ericsson Aaron C. , Reinero Carol , Gull Tamara , Lyons Bridget M. 
Published: January 2025

Abstract

OBJECTIVE
To document differences in the microbiota of healthy cats versus cats with urethral obstruction (UO); compare the urinary microbiota with the oral, preputial, and rectal microbiota; and demonstrate that 16S rRNA gene sequencing will reveal rich and diverse urinary microbiota.

METHODS
15 client-owned cats with UO and 15 age-matched healthy cats were included from July 2020 through April 2021. Exclusion criteria were evidence of urinary tract infection, urolithiasis, antimicrobial administration, urinary catheterization in the past 30 days, or a comorbidity. This study was a prospective, observational study. Both groups had a baseline CBC, chemistry panel, urinalysis, urine culture, and focal bladder ultrasound. Swabs of the cystocentesis site, buccal mucosa, rectum, prepuce, and urinary samples were collected, and 16S rRNA gene sequencing was used to compare the groups and sites.

RESULTS
Differences in the microbiota richness and diversity were found in the urine of cats with UO (n = 15) compared to healthy cats (15), along with differences in the preputial and oral samples, supporting the presence of a urinary dysbiosis in cats with UO.

CONCLUSIONS
Our preliminary data demonstrates a dramatic change in the urinary microbiota of cats with UO along with changes in microbiota in other sites compared to healthy cats.

CLINICAL RELEVANCE
A urinary dysbiosis in cats with UO has been minimally supported in prior studies using 16S rRNA gene sequencing. Although these are preliminary results, documenting this dysbiosis in cats with UO provides a potential avenue for novel therapeutics.
An Innovative Approach to Enhance Cross-Border E-Commerce Merchandise Experience with Virtual Reality Technology
Authors: Yin Jia 
Published: January 2025

Abstract
At present, cross-border e-commerce has become an important engine for the development of global trade. In the context of virtual reality technology, this topic first carries out the analysis of consumers’ demand preferences for cross-border e-commerce goods. The relevant variables are selected based on SOR theory and behavioral theory, and after the research hypotheses are proposed, multiple regression analysis is applied to verify the hypotheses and explore the influence path of virtual reality technology to enhance cross-border e-commerce commodity experience and consumer purchase intention. Combined with demand analysis and the analysis of influencing factors, innovative methods of virtual reality technology to enhance cross-border e-commerce commodity experiences are summarized. Most consumers have higher demand (more than 50%) and a positive willingness to use virtual reality technology for merchandise display (more than 70%). The vividness, interactivity, and immersion of VR merchandise display further positively affect consumers’ purchasing intention by positively influencing virtual haptics (P < 0.01). Haptics needs to play a positive role in it. It can be used to improve the consumer goods experience in cross-border e-commerce and promote the continuous development of the e-commerce industry by perfecting the virtual reality technology, improving the interactivity and social experience, optimizing the cross-platform compatibility, as well as strengthening the data security and privacy protection.