bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of number and type of identified antigen on transplant-free survival in hypersensitivity pneumonitis
Authors: Kypreos Margaret , Batra Kiran , Glazer Craig S. , Adams Traci N. 
Published: September 2022

Background
Identification of inciting antigen can affect diagnostic confidence, quality of life, and prognosis in patients with HP. It is unknown whether the number and type of antigen affect results of diagnostic testing or prognosis, whether antigen identified by clinical history alone affects prognosis, and whether feather exposure is associated with outcomes similar to those of other antigens.

Methods
To evaluate whether the number or type of antigen identified by clinical history alone affects clinical outcomes, we evaluated a retrospective cohort of patients with a high or definite probability of HP based on recent guidelines.

Results
In our retrospective cohort, 136 patients met high or definite probability of HP and were included in the analysis. Median transplant-free survival was better in patients with antigen identified on clinical history alone than patients without identified antigen. Feather exposure was associated with improved TFS compared to patients without antigen identified; there was no difference in TFS between patients with feather exposure and either mold or live bird exposure. Mold antigen was associated with increased risk of fibrotic HP compared to avian antigen. Among patients with identified antigen, the number and type of antigen did not affect TFS.

Discussion
Our study suggests that clinical history is adequate for providing prognostic information to patients with HP and classifying the diagnostic probability of HP according to recent guidelines. Feather exposure should be considered an inciting antigen in patients with ILD.
Factors associated with modern contraceptive use among men in Pakistan: Evidence from Pakistan demographic and health survey 2017-18
Authors: Ali Ahmad , Zar Abu , Wadood Ayesha 
Published: September 2022

Objective
The role of men in family planning is critical in patriarchal societies like Pakistan. The objective of this study is to explore the predictors of modern contraceptive use among Pakistani men.

Methods
This study is a secondary analysis of Pakistan demographic and health survey (PDHS) 2017–18 data. The study sample consists of 3691 ever married men aged 15–49 years. Pearson’s chi square test and logistic regression were used to find out the determinants of modern contraceptive use among men. Data analysis was carried out in December, 2020.

Results
Findings of logistic regression showed that men who were uneducated (aOR = 0.746; 95% CI = 0.568–0.980), residing in Sindh (aOR = 0.748; 95% CI = 0.568–0.985), Baluchistan (aOR = 0.421; 95% CI = 0.280–0.632) or FATA (aOR 0.313; 95% CI 0.176–0.556) and those who belonged to the poorest wealth quintile (aOR = 0.569; 95% CI = 0.382–0.846) were less likely to use modern contraceptives. Men who did not wish for another child (aOR = 2.821; 95% CI = 2.305–3.451) had a higher likelihood of modern contraceptive use. Finally, men who thought that contraception was women’s business (aOR = 0.670; 95% CI = 0.526–0.853) and those who did not discuss family planning with health worker (aOR = 0.715; 95% CI = 0.559–0.914) were also less likely to use modern contraceptives.

Conclusion
Reproductive health education of males, targeting males, in addition to, females for addressing family planning issues and improvement of family planning facilities in socioeconomically under-privileged regions are suggested to improve contraceptive use among couples.
Risk factors and prognosis of acute lactation mastitis developing into a breast abscess: A retrospective longitudinal study in China
Authors: Li Daxue , Li Jiazhen , Yuan Yuan , Zhou Jing , Xiao Qian , Yang Ting , Li Yili , Jiang Lili , Gao Han 
Published: September 2022

Background
Breast abscess is developed on the basis of acute mastitis, which will cause damage to the physical and mental health of lactating women and is an important factor affecting the rate of breastfeeding. This study examined the risk factors for mastitis to develop into breast abscess, and analyzed the distribution of pathogenic bacteria, bacterial resistance, and treatment outcome.

Methods
The medical records of 316 cases of mastitis and 219 cases of breast abscess were retrospectively collected. We analyzed the bacterial distribution of mastitis and breast abscess, and compared the differences of bacterial drug resistance. Univariate analysis and binary logistic regression were used to analyze the following aspects: age, primiparity or not, history of breast surgery, body temperature, puerperium or not, onset time, located in the nipple/areolar complexe area or not, history of massage by non-professionals, staphylococcus aureus/methicillin-resistant staphylococcus aureus (MRSA) infection or not, diabetes and white blood cell count.

Results
Of the 535 patients, 203 (37.9%) were positive for staphylococcus aureus. There were 133 (65.5%) cases of methicillin-sensitive staphylococcus aureus (MSSA) and 70 (34.5%) cases of MRSA. Concerning bacterial drug resistance, a statistical analysis showed that MSSA had high resistance rate to penicillin (96.2%), ampicillin (91%), clindamycin (42.9%) and erythromycin (45.9%). MRSA had a high resistance rate to penicillin (100%), ampicillin (98.6%), oxacillin (95.7%), erythromycin (81.4%), clindamycin (80%), and amoxicillin (31.7%). Risk factors for progression of mastitis to breast abscess include a body temperature<38.5°C, a postpartum time ≥ 42 days, an onset time ≥ 2 days, lesions in the nipple/areolar complex area, a history of massage by non-medical staff and bacterial cultures for milk or pus that test positive for staphylococcus aureus or MRSA (P < 0.001).

Conclusions
The most common pathogenic bacteria of mastitis and breast abscess is staphylococcus aureus. There are many risk factors for mastitis to develop into breast abscess. We should take effective measures for its risk factors and select sensitive antibiotics according to the results of bacterial culture to reduce the formation of breast abscess.
The effectiveness of low-dosed outpatient biopsychosocial interventions compared to active physical interventions on pain and disability in adults with nonspecific chronic low back pain: A protocol for a systematic review with meta-analysis
Authors: Hochheim Martin , Ramm Philipp , Amelung Volker 
Published: September 2022

Background
Best outpatient treatment of nonspecific chronic low back pain is high-dosed exercise that is maintained after therapy. Primary care biopsychosocial intervention (PCBI) is an outpatient multicomponent intervention that includes an active component (exercise, physical activity, or physiotherapy) and at least one psychological, social, or occupational component. Research has shown that PCBI can reduce pain intensity and disability. While scattered studies support low-dosed (<15 treatment hours) PCBI, there is no systematic review comparing the effectiveness of low-dosed PCBI treatment with traditional physical activity interventions in adults with nonspecific chronic low back pain (CLBP).

Inclusion criteria
Randomised controlled trials that evaluate low-dosed outpatient biopsychosocial interventions compared to physical treatment with an active component such as exercise, physical activity or usual physiotherapy treatment for adult participants (18 years or older) who suffer from nonspecific CLBP will be included.

Methods
A comprehensive search of multiple databases will be used to find relevant studies. The databases will be searched from inception to December 2021, with English or German language restrictions imposed. Keywords and derivatives of “chronic back pain”, “exercise intervention”, “cognitive-behavioral therapy”, “primary care” and “randomized controlled trials” will be used. Sources will include CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL), Ovid Medline, Physiotherapy Evidence Database (PEDro), PubMed and Web of Science.

Discussion
To our knowledge, this will be the first systematic review and meta-analysis of narrowly defined low- dosed PCBI across populations with nonspecific chronic low back pain. The objective of this review is to evaluate the effectiveness of low-dosed outpatient biopsychosocial interventions versus physical active interventions on pain intensity and disability in adults with CLBP. This study will provide evidence that could improve treatment options for patients with nonspecific CLBP.

Trail registration
Systematic review registration number: PROSPERO 2022 CRD42022302771. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022302771
ADENOMATOUS POLYPOSIS PHENOTYPE IN BMPR1A AND SMAD4 VARIANT CARRIERS
Authors: Rosner Guy , Petel-Galil Yael , Laish Ido , Levi Zohar , Kariv Revital , Strul Hana , Gilad Ophir , Gluck Nathan 
Published: September 2022

BACKGROUND:
Variants in SMAD4 or BMPR1A cause juvenile polyposis syndrome (JPS), a rare autosomal dominant condition characterized by multiple gastrointestinal hamartomatous polyps. A phenotype of attenuated adenomatous polyposis without hamartomatous polyps is rare.

METHODS:
We describe a retrospective cohort of patients with SMAD4 or BMPR1A heterozygous germline variants, having ≥10 cumulative colorectal adenomas and/or colorectal cancer without hamartomatous polyps. All patients had multigene panel and duplication/deletion analysis to exclude other genetic syndromes.

RESULTS:
The study cohort included eight patients. The pathogenic potential of the variants was analyzed. Variants detected included 4 missense variants, 1 nonsense variant, 1 splice site variant, and 2 genomic deletions. Features of pathogenicity were present in most variants, and co-segregation of the variant with polyposis or colorectal cancer (CRC) was obtained in 7 of the 8 families. Three of 8 patients had CRC (age <50) in addition to polyposis phenotype. Two patients had extraintestinal neoplasms (pancreas and ampulla of Vater).

DISCUSSION:
The clinical phenotype of SMAD4 and BMPR1A variants may infrequently extend beyond the classical JPS phenotype. Applying multigene panel analysis of hereditary cancer-related genes in patients with unexplained polyposis can provide syndrome-based clinical surveillance for carriers and their family members.
Avaliação das Perdas de Água e Solo em Pastagem Inserida em Ambiente de Cerrado Brasileiro sob Chuva Simulada
Authors: Confessor Jefferson Gomes , Silva Lara  Luíza , Araújo Paula Meirilane Soares 
Published: September 2022

Pastagens ocupam extensas áreas do território nacional, as quais apresentam características heterogêneas que variam de acordo com o clima, fertilidade e manejo. A erosão hídrica gerada pela ação das chuvas se mostra como uma das principais fontes promotoras do depauperamento dos solos no Brasil, a qual também expõe comportamento distinto espacialmente e temporalmente. Deste modo, esta pesquisa tem por objetivo avaliar as perdas de água e solo de uma pastagem inserida em região de Cerrado em dois períodos distintos do ano (primavera e verão), visando compreender a dinâmica hidrogeomorfológica do uso em questão. Para tal, utilizando-se de um simulador de chuvas calibrado para replicar pluviosidades de alta intensidade semelhantes às ocorrentes na região de estudo (Uberlândia-MG), replicou-se precipitações com intensidade de 64,34 mm/h em um tempo de 30 minutos (32,17 mm) sobre 4 parcelas de erosão. No geral, a pastagem da área de estudo se apresentou em boas condições de qualidade, expondo baixos valores de água e sedimentos perdidos, sendo os maiores volumes escoados no verão e maiores taxas erodidas no inverno. Os valores encontrados estão ligados às variações sazonais climáticas expressas na região, as quais refletiram nos hábitos de crescimento vegetativo das plantas, gerando alterações na qualidade estrutural das pastagens, sendo verificado que o período de retorno das chuvas na região (transição inverno-verão) se comporta como fase mais susceptível para o desencadeamento de processos erosivos.
Employee Engagement Comparative Study of Baby Boomers, x, and y Generation Workers in Transportation and Logistics Delivery service Companies Semarang
Authors: Kurniawati Nurul Imani 
Published: September 2022

Studies related to workers across generations have caught the attention of many researchers. For the first time in history, the company is inhabited by workers from various generations to be able to work side by side. How workers in each generation interact with and influence the organization they work for is still an interesting research gap to study. However, the studies examining employee engagement in the Baby Boomers generation, X generation and Y generation in transportation companies and logistics delivery services are still limited. Therefore, this study aims to conduct research on the differences in employee engagement in the Baby Boomers generation, X generation and Y generation in transportation and logistics delivery service companies in Semarang. To fulfill this goal, the study was conducted on workers who were grouped by generation according to age or year of birth. To these respondents, employee engagement was measured which was then carried out a comparative test to determine the significance of differences in employee engagement in each generation. The results of the statistical tests carried out show that statistically it can be proven that workers from the Baby Boomer generation, X generation and Y generation have different employee engagement
Thyrotropin and body mass index, are they related?
Authors: Ivo Catarina R. , Duarte Vitória , Veríssimo David , Silva João , Passos Dolores , Lopes Luís , Jácome de Castro João , Marcelino Mafalda 
Published: September 2022

Abstract

Objectives
It is well recognized that overt thyroid dysfunction is associated with changes in body mass index (BMI). However, there is ongoing debate regarding the influence of thyroid stimulating hormone (TSH) on BMI, in euthyroid subjects. The aim of this study is to examine the association of TSH with BMI in an outpatient population without evidence of thyroid disease.

Methods
Cross-sectional study conducted in an Endocrinology Department. We identified the latest TSH and BMI measurements in 923 patients from the reference euthyroid population. All patients with positive thyroid autoimmunity and nodules were excluded. We performed a linear regression analysis using SPSSv.025.

Results
923 adult patients were evaluated. 79.4% were males, with a mean age of 67.6 years old. Mean TSH level was 1.78 mIU/L and mean BMI was 29.2 kg/m2. A significant negative correlation between serum TSH concentration and BMI was evident (p=0.04; r=−0.067). Statistical significance was lost when performing subgroup analysis, for males and females (p=0.19 and p=0.075), elderly (≥65 years) and non-elderly (p=0.55 and p=0.32) and also obese (BMI ≥30 kg/m2) and non-obese (p=0.39 and p=0.13).

Conclusions
The relationship between BMI and TSH is not consensual in the literature. This study included a large cohort sample of euthyroid patients, majority men and with negative autoimmunity. Our results support the hypothesis that variation in thyroid status within the normal range, could have a negative effect on BMI, contrary to most published studies.
Spider-based FOPID controller design for temperature control in aluminium extrusion process
Authors: Murugesan Ramasubramanian , Marimuthu Thirumarimurugan 
Published: September 2022

AbstractBased on the exit temperature in the aluminium extrusion process, the quality of the aluminium bars is obtained in the industries. Control of temperature plays a significant role to obtain the quality of the aluminium bars or rods. Problems are still encountered in the design of proper temperature control schemes in the industries. A new control scheme is presented here, to address the temperature control in the aluminium extrusion process. Spider-based fractional-order PID controller scheme is simulated for the aluminium extrusion plant using MATLAB and its toolbox. It gives the improved result for reducing the time delay, rise time and settling time in the process. Integral square error performance criteria are considered an objective function. The minimization of objective function gives good results. Comparisons of the presented control scheme with the conventional control methods are presented.
Marginal Communities and Cooperative Strategies in the Kerma Pastoral State
Authors: Walsh Carl 
Published: September 2022

AbstractThis paper examines the relationship between marginal Nubian communities—who are culturally different and who occupy peripheral contexts—and the Kerma “pastoral state” in Upper Nubia during the Classic Kerma period (1750–1550 BCE). It is argued that the funerary assemblages of two such communities—Mirgissa and al-Widay I—document localized identities and active roles in cross-cultural interactions with other cultural groups. These interactions and identities may have been intentionally encouraged and utilized by the Kerma state in order to gain access to exchange systems and maintain power within a more decentralized “pastoral state.” Cooperative processes such as commensality and social reception presented mechanisms for forming friendly relationships with these communities and a variety of Nile valley and desert groups and polities. It is argued that these communities were not marginalized and exploited by the state and but instead used their marginality to achieve degrees of autonomy and form their own localized practices.
Off the pitch: semiotics of liminality between space and play
Authors: Ragonese Ruggero 
Published: September 2022

AbstractPlaying fields are “spaces where the communitas suspends its everyday life and structures” and “The internal logic of sporting games is connected to values from the social context” (Parlebas, Pierre. 2013. Motor praxeology: A new scientific paradigm. In Mariann Vaczi (ed.), Playing fields: Power, practice, and passion in sport, 127–144. Reno: University of Nevada Press). But what about the space in between? What kind of semiotics organisation can be detected in the membrane between player and liminal space where spectators are not allowed yet specific characters needed to carry out an event? We can therefore identify a liminality that can be connected either to the controlled or the wild playing field and depending on which of the two is the case can be analysed according to the degree of regulated system of signs which they produce. This implies different pathways and rituals: as matches are played, a variety of bodily activities may be taking place concurrently. Furthermore, it is inevitable that these activities attract the attention of the audience or alternately lead a player to interact with a non-player.In this article, I will first try to identify certain semiotics features, especially connected to Eco’s Peircian concept of Encyclopedia, that characterize the status of liminal space around the playing field. Then I will focus on liminality in soccer, investigating what kinds of interaction exist outside the playing area.
Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s disease
Authors: Khan Arshad H. , Lee Lydia K. , Smith Desmond J. 
Published: September 2022

AbstractExposure to pesticides in humans increases the risk of Parkinson’s disease (PD), but the mechanisms remain poorly understood. To elucidate these pathways, we dosed C57BL/6J mice with a combination of the pesticides maneb and paraquat. Behavioral analysis revealed motor deficits consistent with PD. Single-cell RNA sequencing of substantia nigra pars compacta revealed both cell-type-specific genes and genes expressed differentially between pesticide and control, includingFam241b,Emx2os,Bivm,Gm1439,Prdm15, andRai2. Neurons had the largest number of significant differentially expressed genes, but comparable numbers were found in astrocytes and less so in oligodendrocytes. In addition, network analysis revealed enrichment in functions related to the extracellular matrix. These findings emphasize the importance of support cells in pesticide-induced PD and refocus our attention away from neurons as the sole agent of this disorder.
Fast Event-Related Mapping of Population Fingertip Tuning Properties in Human Sensorimotor Cortex at 7T
Authors: Khalife Sarah , Francis Susan T. , Schluppeck Denis , Sánchez-Panchuelo Rosa-Maria , Besle Julien 
Published: September 2022

AbstractfMRI studies that investigate somatotopic tactile representations in the human cortex typically use either block or phase-encoded stimulation designs. Event-related (ER) designs allow for more flexible and unpredictable stimulation sequences than the other methods, but they are less efficient. Here, we compared an efficiency-optimized fast ER design (2.8-s average intertrial interval; ITI) to a conventional slow ER design (8-s average ITI) for mapping voxelwise fingertip tactile tuning properties in the sensorimotor cortex of six participants at 7 Tesla. The fast ER design yielded more reliable responses compared with the slow ER design, but with otherwise similar tuning properties. Concatenating the fast and slow ER data, we demonstrate in each individual brain the existence of two separate somatotopically-organized tactile representations of the fingertips, one in the primary somatosensory cortex (S1) on the postcentral gyrus, and the other shared across the motor and premotor cortices on the precentral gyrus. In both S1 and motor representations, fingertip selectivity decreased progressively, from narrowly-tuned Brodmann area (BA) 3b and BA4a, respectively, toward associative parietal and frontal regions that responded equally to all fingertips, suggesting increasing information integration along these two pathways. In addition, fingertip selectivity in S1 decreased from the cortical representation of the thumb to that of the pinky.
Degradation Of Lampung Language On Marga Sekampung Community In Gunung Raya East Lampung
Authors: Septiyana Linda , Sari Yeasy Agustina , Muhammad Hasanuddin 
Published: September 2022

This study aims to: 1) describe the existence of Lampung language on Marga Sekampung community in Gunung Raya 2) analyze the factors that influence the Lampung language degradation on Marga Sekampung community in Gunung Raya. This study is a qualitative research. This study was carried out in Gunung Raya, Marga Sekampung, East Lampung. The findings of this study are 1) the existence of Lampung language on Marga Sekampung community in Gunung Raya in the cultural and social environment so far is still well maintained. However, there is a language shifting in the existence of Lampung language of Marga Sekampung community in family environment, especially the use of the Lampung language between parents and children as well as the use of Lampung Language between children and children. 2) The factors that influence the Lampung language degradation on Marga Sekampung community in Gunung Raya especially on children or teenangers are their own selves factors, lack of socialization in the family environment, and interaction with their friends. Based on the results of this study, it should be for children and parents of Marga Sekampung community in Gunung Raya get used to using Lampung language in their daily life so that it does not become extinct.