bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of interventions by a community pharmacist on care burden for people with dementia: development and randomized feasibility trial of an intervention protocol
Authors: Nanaumi Yoko , Yoshitani Atsushi , Onda Mitsuko 
Published: June 2022

Abstract
Background
Traditionally, the role of pharmacists has been to manage and monitor pharmacotherapy for patients with dementia. However, additional intervention by community pharmacists to collect and share patient information with other professionals may help reduce the care burden among caregivers. The aims of this study were to examine (1) the feasibility of a designed community pharmacist working procedure in dementia care and (2) the expected impact of pharmacist intervention on care burden.

Methods
This was a randomized, open-label, parallel-group feasibility study, involving eight Nara City pharmaceutical association member pharmacies that provided consent to participate. These pharmacies were assigned to an intervention group or a control group at a 1:1 ratio. The subjects were patients with dementia and their primary caregivers that visited the participating pharmacies and provided consent to participate. Pharmacists in the intervention group actively collected information from the patients’ family physicians and care managers and intervened to address medication-related problems, while those in the control group only performed their normal duties. The primary endpoint was a change in the caregiver’s score on the Japanese version of Zarit Caregiver Burden interview (J-ZBI) from the baseline to after 5 months of follow-up. The changes in mean J-ZBI scores from the beginning to the end of the study period of the two groups were compared.

Results
Obtaining consent from caregivers was certainly difficult, but possible. Pharmacists managed to fill out the survey form while practising pharmaceutical care. Totally, nine patients and nine caregivers in the intervention group and nine patients and eight caregivers in the control group completed the study. The changes in J-ZBI scores could be calculated for seven cases in the intervention group and five cases in the control group. The J-ZBI scores were found to decrease by 1.0 in the intervention group and increase by 3.0 in the control group.

Conclusions
The protocol presented was considered feasible, but, the intervention process needs to be simplified in order to conduct a large study. Also, improvements are needed in the various survey forms and in the explanatory documents for caregivers. Although the sample size was small, the effect sizes suggested that community pharmacist interventions for patient with dementia may reduce the care burden for caregivers.

Trial registration
UMIN000039949 (registration date: 1 April 2020, retrospectively registered)
Quality of patient- and proxy-reported outcomes for children with impairment of the upper extremity: a systematic review using the COSMIN methodology
Authors: Kalle J. P. Ruben , Saris Tim F. F. , Sierevelt Inger N. , Eygendaal Denise , van Bergen Christiaan J. A. 
Published: June 2022

Abstract
Background
As patient-reported outcome measures (PROMs) have become of significant importance in patient evaluation, adequately selecting the appropriate instrument is an integral part of pediatric orthopedic research and clinical practice. This systematic review provides a comprehensive overview of PROMs targeted at children with impairment of the upper limb, and critically appraises and summarizes the quality of their measurement properties by applying the COnsensus-based Standards for selection of health Measurement INstruments (COSMIN) methodology.

Methods
A systematic search of the MEDLINE and EMBASE databases was performed to identify relevant publications reporting on the development and/or validation of PROMs used for evaluating children with impairment of the upper extremity. Data extraction and quality assessment (including a risk of bias evaluation) of the included studies was undertaken by two reviewers independently and in accordance with COSMIN guidelines.

Results
Out of 6423 screened publications, 32 original articles were eligible for inclusion in this review, reporting evidence on the measurement properties of 22 self- and/or proxy-reported questionnaires (including seven cultural adaptations) for various pediatric orthopedic conditions, including cerebral palsy (CP) and obstetric brachial plexus palsy (OBPP). The measurement property most frequently evaluated was construct validity. No studies evaluating content validity and only four PROM development studies were included. The methodological quality of these development studies was either ‘doubtful’ or ‘inadequate’. The quantity and quality of the evidence on the other measurement properties of the included questionnaires varied substantially with insufficient sample sizes and/or poor methodological quality resulting in significant downgrading of evidence quality.

Conclusion
This review provides a comprehensive overview of currently available PROMs for evaluation of the pediatric upper limb. Based on our findings, none of the PROMs demonstrated sufficient evidence on their measurement properties to justify recommending the use of these instruments. These findings provide room for validation studies on existing pediatric orthopedic upper limb PROMs (especially on content validity), and/or the development of new instruments.
Improved conditional differential attacks on lightweight hash family QUARK
Authors: Lu Xiaojuan , Li Bohan , Liu Meicheng , Lin Dongdai 
Published: June 2022

AbstractNonlinear feedback shift register (NFSR) is one of the most important cryptographic primitives in lightweight cryptography. At ASIACRYPT 2010, Knellwolf et al. proposed conditional differential attack to perform a cryptanalysis on NFSR-based cryptosystems. The main idea of conditional differential attack is to restrain the propagation of the difference and obtain a detectable bias of the difference of the output bit. QUARK is a lightweight hash function family which is designed by Aumasson et al. at CHES 2010. Then the extended version of QUARK was published in Journal of Cryptology 2013. In this paper, we propose an improved conditional differential attack on QUARK. One improvement is that we propose a method to select the input difference. We could obtain a set of good input differences by this method. Another improvement is that we propose an automatic condition imposing algorithm to deal with the complicated conditions efficiently and easily. It is shown that with the improved conditional differential attack on QUARK, we can detect the bias of output difference at a higher round of QUARK. Compared to the current literature, we find a distinguisher of U-QUARK/D-QUARK/S-QUARK/C-QUARK up to 157/171/292/460 rounds with increasing 2/5/33/8 rounds respectively. We have performed the attacks on each instance of QUARK on a 3.30 GHz Intel Core i5 CPU, and all these attacks take practical complexities which have been fully verified by our experiments. As far as we know, all of these results have been the best thus far.
Effect of COVID-19 infection on psychological aspects of pre-schooler children: a cross-sectional study
Authors: Ahmed Gellan K. , Mostafa Sayed , Elbeh Khaled , Gomaa Hamdy M. , Soliman Saeed 
Published: June 2022

Abstract
Background
Coronavirus disease 2019 (COVID-19) had a tremendous effect on individual’s lives worldwide. The pandemic’s significant socioecological impact is one of the many burdens children confront in the current crises. As a result, this study was designed to determine the psychological impacts of the COVID-19 pandemic on preschoolers, particularly the consequences of COVID-19 infection. This study involved 138 children aged 2–5.11 years old who were classified into two groups based on their COVID-19 infection history, which was documented via a PCR test. All participants were assessed by the Socioeconomic Scale and The Children’s Behavior Checklist (CBCL).

Results
COVID-19 infection was found in 21.7% of the children who participated in this study. Furthermore, children with COVID-19 had a higher percentage of clinical rating on the CBCL Profile of DSM-5 scales for affective problems (13.3 vs. 7.4%), anxiety problems (13.3 vs. 9.3%), pervasive developmental problems (20 vs. 13%), and oppositional defiant problems (6.7 vs. 5.6%) than children without COVID-19. Anxiety and somatic problems had a positive correlation with the impact of the COVID-19 pandemic on the lives of children.

Conclusions
Children infected with COVID-19 were more likely to have psychological issues, such as affective disorders, anxiety problems, pervasive developmental problems, and oppositional defiant problems. These psychological issues had a relationship with the impact of the COVID-19 pandemic on the lives of children.
Risk assessment score for adverse pregnancy outcome in systemic lupus erythematosus patients
Authors: Makarm Wafaa K. , Zaghlol Rabab S. , Kotb Lobna I. 
Published: June 2022

Abstract
Background
Systemic lupus is a chronic autoimmune multisystem disease that mainly affects females of childbearing age. SLE still possesses risks during pregnancy that lead to poor maternal and fetal outcomes. The objectives of the study were to identify factors associated with unfavorable pregnancy outcomes and develop a predictive risk score for adverse pregnancy outcomes in patients with SLE.

Results
The main predictive factors associated with adverse pregnancy outcomes among lupus patients in multiple linear regression were an absence of remission for at least 6 months before conception, preexisting lupus nephritis, active disease at conception, C3 hypocomplementemia, and antiphospholipid antibody syndrome. Each predictor is assigned a weighted point score, and the sum of points represents the risk score. The area under the receiver operating characteristic curve (ROC) was 0.948 (95% confidence interval, 0.908–0.988), suggesting that the score had strong discriminatory power for adverse pregnancy outcomes.

Conclusions
In this study, a predictive model with a risk score classification for adverse pregnancy outcomes in SLE patients was developed. This could help rheumatologists identify high-risk pregnant patients for better disease monitoring and management, resulting in better maternal/fetal outcomes.
Effects of curvature on epithelial tissue —Coordinated rotational movement and other spatiotemporal arrangements
Authors: Happel L. , Wenzel D. , Voigt A. 
Published: June 2022

Abstract
Coordinated movements of epithelial tissue are linked with active matter processes. We here consider the influence of curvature on the spatiotemporal arrangements and the shapes of the cells. The cells are represented by a multiphase field model which is defined on the surface of a sphere. Besides the classical solid and liquid phases, which depend on the curvature of the sphere, on mechanical properties of the cells and the strength of activity, we identify a phase of global rotation. This rotation provides a coordinated cellular movement which can be linked to tissue morphogenesis. This investigation on a sphere is a first step to investigate the delicate interplay between topological constraints, geometric properties and collective motion. Besides the rotational state we also analyse positional defects, identify global nematic order and study the associated orientational defects.
Simple and robust analytical model for dipolar resonances in plasmonic particle-substrate systems
Authors: Castro Claudio Silvestre , Bruyant Aurelien , Vincent Rémi 
Published: June 2022

Abstract
We revisit the theory of light-matter interactions induced by a small metallic particle near a planar surface. The resonant features of the coupled system are investigated using an approach that determines the particle permittivity that brings the system to resonance. Analytical results are presented for the case of a spherical particle near a flat substrate and compared to previous results, whereas a general recipe involving Green's function is also given. In contrast to previous work, our analytical results allow the determination of eigenfrequencies in the presence of strong temporal dispersion and include radiative damping. Furthermore, the model can be related to stationary normal modes, thereby providing physical insight and a design tool for surface-enhanced devices and sensing.
Short- and Long-Term Outcomes of Pancreatic Cancer Resection in Elderly Patients: A Nationwide Analysis
Authors: Henry Anne Claire , Schouten Thijs J. , Daamen Lois A. , Walma Marieke S. , Noordzij Peter , Cirkel Geert A. , Los Maartje , Besselink Marc G. , Busch Olivier R. , Bonsing Bert A. , Bosscha Koop , van Dam Ronald M. , Festen Sebastiaan , Groot Koerkamp Bas , van der Harst Erwin , de Hingh Ignace H. J. T. , Kazemier Geert , Liem Mike S. , de Meijer Vincent E. , Nieuwenhuijs Vincent B. , Roos Daphne , Schreinemakers Jennifer M. J. , Stommel Martijn W. J. , Molenaar I. Quintus , van Santvoort Hjalmar C. ,   for the Dutch Pancreatic Cancer Group
Published: June 2022

Abstract
Background
The number of elderly patients with pancreatic cancer is growing, however clinical data on the short-term outcomes, rate of adjuvant chemotherapy, and survival in these patients are limited and we therefore performed a nationwide analysis.

Methods
Data from the prospective Dutch Pancreatic Cancer Audit were analyzed, including all patients undergoing pancreatic cancer resection between January 2014 and December 2016. Patients were classified into two age groups: <75 and ≥75 years. Major complications (Clavien–Dindo grade 3 or higher), 90-day mortality, rates of adjuvant chemotherapy, and survival were compared between age groups. Factors associated with start of adjuvant chemotherapy and survival were evaluated with logistic regression and multivariable Cox regression analysis.

Results
Of 836 patients, 198 were aged ≥75 years (24%) and 638 were aged <75 years (76%). Median follow-up was 38 months (interquartile range [IQR] 31–47). Major complications (31% vs. 28%; p = 0.43) and 90-day mortality (8% vs. 5%; p = 0.18) did not differ. Adjuvant chemotherapy was started in 37% of patients aged ≥75 years versus 69% of patients aged <75 years (p < 0.001). Median overall survival (OS) was 15 months (95% confidence interval [CI] 14–18) versus 21 months (95% CI 19–24; p < 0.001). Age ≥75 years was not independently associated with OS (hazard ratio 0.96, 95% CI 0.79–1.17; p = 0.71), but was associated with a lower rate of adjuvant chemotherapy (odds ratio 0.27, 95% CI 0.18–0.40; p < 0.001).

Conclusions
The rate of major complications and 90-day mortality after pancreatic resection did not differ between elderly and younger patients; however, elderly patients were less often treated with adjuvant chemotherapy and their OS was shorter.
Self-Assembly of a Zinc Bacteriochlorophyll-d Analog with a Lipophilic Tertiary Amide Group in the 17-Substituent
Authors: Shoji Sunao , Stepanenko Vladimir , Würthner Frank , Tamiaki Hitoshi 
Published: June 2022

Abstract
Self-assembled aggregates of bacteriochlorophyll(BChl)-c/d/e pigments play key roles in major light-harvesting antenna systems of photosynthetic green bacteria. Herein, we report the self-assembly of a lipophilic zinc BChl-d model with an N,N-didodecylamide in the 17-substituent. The present model formed two types of J-aggregates, which formed under kinetic and thermodynamic controls.
Risk factors of developing inflammatory bowel diseases
Authors: Zimna Aleksandra Iwona , Wróblewski Hubert , Chojęta Dariusz , Zygmunt Ewelina , Kozłowska Anna 
Published: June 2022

Introduction: The pathogenesis of inflammatory bowel disease (IBD) is still unknown. It is known to be multi-factorial. The world is seeing an ever increasing number of new cases of these diseases. Ulcerative colitis and Crohn's disease are the main representatives of inflammatory bowel diseases.
Aim: The aim of the study was to analyze risk factors for inflammatory bowel diseases.
Materials and methods: The results were obtained on the basis of a questionnaire survey.
Results: 95 people took part in the survey aged 16 to 72 years old. 35.8% were men and 64.2% were women. 78% lives in cites, only 22% are rural residents. 56.4% of them suffer from ulcerative colitis and 43.6% from Crohn's disease. 40.4% of respondents smoked cigarettes in the past, but currently only 12.6% are still struggling with the addiction. Only 4 people declare brushing their teeth after each meal. 18 people confirm the presence of NCDH in their families, 19 suffer from other autoimmune diseases at the same time. 2 people from among the respondents - also celiac disease. One person had Salmonella and Shigella infection. Conclusions: Due to the mutual cause-effect relationships between genetic predisposition and the influence of environmental factors, it is currently difficult to state which of the above factors plays a decisive role. Environmental factors that play a role in the etiopathogenesis of IBD include, first and foremost, the intestinal bacterial flora, diet, human environment and smoking. There is a clear tendency for the coexistence of autoimmune diseases in the group of patients with NCJ and a predisposition to the disease in the family. There is also a need to educate patients about the benefits of taking probiotics and taking care of proper eating habits. Key words: inflammatory bowel diseases, risk of developing the disease, irresponsible patient
The Façade, the Face, and the Sympathies: Opening the Black Box of Symbolic Capital as a Source of Philanthropic Attractiveness
Authors: Shymko Yuliya , Roulet Thomas J , de Melo Pimentel Bernardo 
Published: June 2022

Although most studies on philanthropy have focused on corporate benefactors, limited attention has been given to beneficiaries and their characteristics. The literature thus falls short in explaining how the variance in the perceived value of those characteristics can condition the philanthropic attractiveness of recipients for donors. Drawing from Bourdieu’s concept of symbolic capital and qualitative insights drawn from our empirical context of philanthropy in the field of cultural production in the Russian Federation, we argue that the attractiveness of cultural organizations for potential corporate benefactors depends on a range of determinants, which we classify under the broad umbrellas of respectability and reputability. By using political orientation as a moderator, we show that, although respectability is an indiscriminately attractive part of symbolic capital, reputability, associated with artistic celebrity and renown, can become a deterrent to potential donors when it augments the risk of jeopardizing their relationship with the government. We also demonstrate that a board of trustees, which signals openness to stakeholder involvement, diminishes the returns of reputability for potential donors. We test our hypotheses using original and representative longitudinal data on 449 Russian theaters (2004–2011). Taking an indirect recursive approach to estimate models with high-dimensional fixed effects, we find strong support for our hypotheses across a variety of econometric specifications. Our research offers a unique focus on the beneficiary side of the beneficiary-benefactor relationship, which has both theoretical and practical implications for the literatures on corporate philanthropy, and cultural industries. Supplemental Material: The online appendices are available at https://doi.org/10.1287/orsc.2022.1603 .
A holistic view of the stoma care pathway in Italy: a nationwide learning survey
Authors: Toma Elena , Torre Filippo La , Barone Filippo , Rovere Marcello , Ercolani Maria Sole , Pocek Paola , Filomeno Lucia , Torre Giuseppe La 
Published: June 2022

Background: The therapeutic care pathway for a patient with a stoma starts with a preoperative diagnosis and the decision to form an ostomy, followed by postoperative education, and it continues for as long as the stoma is in place. Clinical studies in this area are often limited to analysing a specific stage in this process, and less attention has been given to how each stage influences the rest of the pathway. Aim: This study aimed to provide a holistic assessment of the entire stoma care pathway, encompassing professional management of emerging complications, as well as the patient's perceptions of care and capacity for self-management, to determine how one management stage might affect another. Method: The study consisted of an anonymous questionnaire with 96 items divided into nine sections. It enrolled people with one or more urinary and/or intestinal stoma/s and lasted from September 2017 to December 2019. Findings: In the sample of 403 ostomates, 52% were female and 48% male, while 74% had an intestinal stoma, 19% a urinary stoma and 7% both. Of all respondents, 52% presented with peristomal lesions. Pre-operatively, a lack of training (76%), stoma siting (70%) and psychological support (92%) were observed. After discharge, 75% had peristomal lesions, 47% had professional care. At the time of the study, 60% were self-sufficient in ostomy care, 52% had lesions, while 38% were unsatisfied with the device used. Conclusion: Detailed discussion is given to peristomal skin care, self-sufficiency, ongoing support and the needs of people with both a urinary and an intestinal stoma. Patient education, psychological support and access to a stoma care specialist all likely affect acceptance and quality of life.
Interferometric laser imaging for droplet-size measurement in spray
Authors: Ma Yarui , Cui Jiwen , Tan Jiubin 
Published: June 2022

An upgraded droplet-size measurement method, based on laser interference particle imaging (IPI) technology, is applied to accomplish high-precision measurement of particle size and spatial distribution of gas–liquid two-phase flow in the atomization field. In this study, an improved morphological-Hough transform interference fringe location algorithm is applied to IPI measurement. The particle size of the standard particle field with a diameter of 24 µm is measured by the upgraded IPI measurement experimentally, whose absolute error and relative error are 0.14 µm and 0.58%, respectively. The atomization field of the 400 µm centrifugal nozzle under different pressures is demonstrated by direct imaging and IPI technology, where the assessment results are evaluated by SMD value and particle size distribution, and the results exhibit good agreement.
Sonic irrigation for removal of calcium hydroxide in the apical root canal: A micro-CT and light-coupled tracking analysis
Authors: Moon Wonjoon , Chung Shin Hye , Chang Juhea 
Published: June 2022

Objective
This study aimed to evaluate the efficacy of three sonic irrigation systems for removal of calcium hydroxide dressing from the apical root canal.

Materials and methods
A total of 96 single-rooted teeth in three categories of root canal curvatures (straight: 0–5°, moderate: 6–20°, and severe: > 20°) were allocated to four groups: conventional needle irrigation, EndoActivator, EQ-S, and Vibringe. The root canals were instrumented using Protaper NEXT and filled with calcium hydroxide. After removal of calcium hydroxide, the remaining volume of calcium hydroxide was measured by micro-CT analysis. Data were compared among root canal curvatures and irrigation systems using the Kruskal-Wallis test and Mann-Whitney test (p < .05). The oscillating range of each irrigation system was measured using light-coupled motion tracking.

Results
The volumes of calcium hydroxide remaining in the canals with severe curvature were significantly higher than in those of straight curvature (p < .05). In the canals of moderate or severe curvature, EQ-S showed the highest removal percentage, followed by EndoActivator, Vibringe, and needle irrigation (p < .05). Light-coupled tracking showed the largest oscillating range in EQ-S (p < .05).

Conclusions
Sonically activated irrigation systems with a flexible tip can be beneficial for calcium hydroxide intracanal dressing removal in the curved apical canals.