bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review on PCR and POC-PCR - A Boon in the Diagnosis of COVID-19
Authors: Amuthalakshmi Sivaperuman , Sindhuja Singaravelan , Nalini Calambur Nagarajan 
Published: May 2022

Abstract:
Ever since the global spread of covid 19, PCR predominantly took the lead in the diagnosis. It amplifies a particular DNA target sequence into millions of copies. To simplify the laboratory-dependent disease diagnosis, the point of care diagnostics (POC) paved the way for lab-on-a-chip-technology. Succeeding that, POC integrated with PCR stole the limelight. This review points out the various diagnostic methods of covid 19 based on PCR and POC-PCR along with its principles, and types clustered regularly interspaced short palindromic repeats (CRISPR) based assays for the rapid, accurate, and easier detection of covid 19.
Supra-therapeutic Anticoagulation with Warfarin: A Cross-sectional
Study
Authors: Sridharan Kannan , Banna Rashed Al , Husain Aysha 
Published: May 2022

Aims:
To identify the extent and associated factors for patients with prolonged prothrombin
time, international normalized ratio (PT-INR), and the dosage modifications were carried
out with warfarin.

Background:
Studies evaluating patients on warfarin with supratherapeutic anticoagulation are
limited. It is vital to understand the management strategies for patients receiving warfarin who are
bleeding and those with only supratherapeutic PT-INR.

Objective:
To evaluate the factors associated with supratherapeutic anticoagulation without bleeding
with warfarin.

Methods:
A cross-sectional study was carried out on patients receiving long-term warfarin with at
least one PT-INR value > 3.2. Percent time in therapeutic range (TTR) was calculated and National
Institute for Health and Care Excellence (NICE) guidelines were adhered to defining anticoagulation
control into good (> 65%) and poor (< 65%).

Results:
One hundred and forty-four patients were recruited. Nearly half of the study population
had PT-INR values between 3.2 and 3.9. On average, individuals had at least 4 times PT-INR values
in the supratherapeutic range. Elderly patients were observed with a significant trend of supratherapeutic
INR. Duration of therapy was significantly correlated with the risk of PT-INR > 4.
Lower TTR was observed in patients with frequent PT-INR > 4 and those patients had significantly
poor anticoagulation control. Duration of warfarin therapy and HAS-BLED scores were observed
to be significant predictors of supratherapeutic INR. Large variations were observed in the modifications
of warfarin dose carried out at various supratherapeutic INR values and consequently PTINR
values.

Conclusion:
We observed that the majority of patients with supratherapeutic INR had their INR
values between 3.2 and 3.9. Elderly patients, with higher HAS-BLED scores and prolonged duration
of warfarin therapy, were observed with an increased risk of supratherapeutic anticoagulation.
Careful dosage modifications are needed particularly in high-risk categories as mentioned above.
Cellular and Molecular Aspects of Managing Familial Hypercholesterolemia: Recent and Emerging Therapeutic Approaches
Authors: Taheri Forough , Taghizadeh Eskandar , Baniamerian Fatemeh , Rostami Daryoush , Rozeian Ahmad , Mohammad Gheibi hayat Seyed , Jamialahmadi Tannaz , Reiner Željko , Sahebkar Amirhossein 
Published: May 2022

Abstract:
Familial hypercholesterolemia (FH) as a high-frequency genetic disorder is diagnosed
based on family and/or patient’s history of coronary heart disease (CHD) or some other atherosclerotic
diseases, LDL-C levels, and/or clinical signs such as tendinous xanthoma, arcus cornealis
before age 45 years as well as a functional mutation in the LDLR, apoB or PCSK9 gene.
Its clinical features are detectable since early childhood. Early diagnosis and timely treatment
increase life expectancy in most patients with FH. Current FH therapies decrease the level of lowdensity
lipoprotein up to ≥50% from baseline with diet, pharmacotherapeutic treatment, lipid
apheresis, and liver transplantation. The cornerstone of medical therapy is the use of more potent
statins in higher doses, to which often ezetimibe has to be added, but some FH patients do not
achieve the target LDL-C with this therapy Therefore, besides these and the most recent but already
established therapeutic approaches including PCSK9 inhibitors, inclisiran, and bempedoic
acid, new therapies are on the horizon such as gene therapy, CRISPR/Cas9 strategy, etc. This
paper focuses on cellular and molecular potential strategies for the treatment of FH.
MISREPRESENTATION SEBAGAI FRAUD DALAM PERKARA KONTRAK ASURANSI YANG DILAKUKAN PENANGGUNG
Authors: Mulhadi Mulhadi , Harianto Dedi 
Published: May 2022

Insurance companies in Indonesia are currently trapped in the stigma of seeking the highest premiums. Many agents do not work according to standards and do not explain in detail the insured party’s rights and obligations. This study aims to determine the meaning of misrepresentation and forms of misrepresentation made by the insurer in an insurance contract case based on court decisions. This normative juridical approach uses content analysis method. The results showed that the insurer failed to provide correct information about the importance of medical check-ups about life insurance, failed to explain the relationship between honesty in disclosing material circumstances with the risk of cancellation of the policy or the consequences of an insurance claim being rejected, failed to present the correct information to policyholders and gives the impression that insurance claims can be made easily, only with a photocopy of the receipt for payment of hospital fees, and the failed to present correct information that the policy can only be closed to other people if the prospective insured has a birth certificate and cannot be replaced by a statement only.
PENGARUH PENGGUNAAN MEDIA SOSIAL DAN LINGKUNGAN KELUARGA TERHADAP MINAT BERWIRAUSAHA PADA MAHASISWA FAKULTAS EKONOMI UNIVERSITAS NEGERI JAKARTA
Authors: Gustina Maria , Sumiati Ati , Mardi Mardi 
Published: May 2022

Abstrak: Penelitian ini bertujuan untuk mengetahui Pengaruh Penggunaan Media Sosial dan Lingkungan Keluarga Terhadap Minat Berwirausaha Pada Mahasiswa Fakultas Ekonomi Universitas Negeri Jakarta. Metode yang digunakan adalah metode kuantitatif. Populasi terjangkau dalam penelitian ini adalah mahasiswa S1 di Fakultas Ekonomi UNJ angkatan 2018 yang berjumlah 269 orang dengan sampel sebanyak 161 orang menggunakan teknik proportional random sampling. Pengumpulan data menggunakan instrument kuesioner dengan skala likert. Uji persyaratan analisis yang dilakukan menujukkan hasil yakni data berdistribusi normal dan linear. Berdasarkan hasil uji hipotesis dan uji koefisien determinasi dapat disimpulkan bahwa semua hipotesis diterima. Koefisien determinasi pada penelitian ini adalah 46,7% yang menunjukkan penggunaan media sosial dan lingkungan keluarga dalam memengaruhi minat berwirausaha sedangkan sisanya dipengaruhi faktor lain yang tidak diteliti. Berdasarkan hasil analisis tersebut dapat disimpulkan bahwa Penggunaan Media Sosial dan Lingkungan Keluarga secara simultan berpengaruh terhadap Minat Berwirausaha.Abstract: This research was conducted on undergraduate students at the Faculty of Economics UNJ. The method used is the survey method with questionnaires. The affordable population in this study was undergraduate students at the Faculty of Economics unj class of 2018 which amounted to 269 people with a sample of 161 people using proportional random sampling techniques. The data analysis techniques used are descriptive analysis, analysis requirement test, hypothesis test, and determination coefficient test. The analysis requirements test conducted showed the results are normal and linear distributed data. Based on the results of hypothesis tests and coefficients of determination, it can be concluded that all hypotheses are accepted. The coefficient of determination in this study was 46.7% which showed the use of social media and family environment in influencing entrepreneurial interests while the rest was influenced by other factors that were not studied. Based on the results of the analysis, it can be concluded that the use of social media and family environment simultaneously affects entrepreneurial interests.
DAMPAK COVID-19 TERHADAP PENAWARAN DAN PENDAPATAN PEKERJA INFORMAL DAERAH ISTIMEWA YOGYAKARTA/IMPACT OF COVID-19 ON THE SUPPLY AND INCOME OF INFORMAL WORKERS IN THE SPECIAL REGION OF YOGYAKARTA
Authors: Murda Handani 
Published: May 2022

Abstrak: Sektor ekonomi informal paling rentan terdampak Covid-19 sehingga penulis tertarik untuk meneliti dampaknya terhadap penawaran tenaga kerja dan pendapatan pekerja informal. Penelitian ini bertujuan untuk mengetahui dampak Covid-19 terhadap penawaran dan pendapatan pekerja informal di Daerah Istimewa Yogyakarta. Data yang digunakan dalam penelitian ini menggunakan mikro data sekunder Survei Angkatan Kerja Nasional (Sakernas) yang dikumpulkan Badan Pusat Statistik pada Agustus 2019 dan Agustus 2020. Analisis menggunakan model regresi simultan dengan variabel intrumental, teknik estimasi two stage least square (2 SLS) dan koreksi bias selektif. Penelitian membahas dampak pandemi Covid-19 dengan pendekatan analisis penawaran dan pendapatan pekerja informal. Pekerja informl merespon cukup signifikan dampak pandemi terhadap penurunan penawaran dan pendapatan. Dampak pandemi terbesar dirasakan pekerja informal pada Sektor Non Pertanian, diikuti pekerja informal laki-laki dan pekerja informal yang tinggal di perkotaan.Abstract: The informal economy sector has been most vulnerable to being affected by Covid-19, so the authors are interested in examining its impact on the supply of labor and the income of informal workers. This study aims to determine the impact of Covid-19 on the supply and income of informal workers in the Special Region of Yogyakarta. The data used in this study uses secondary micro data from the National Labor Force Survey (Sakernas) collected by the Central Statistics Agency in August 2019 and August 2020. The analysis uses a simultaneous regression model with instrumental variables, two stage least square (2 SLS) estimation techniques and corrections. selective bias. The study discusses the impact of the Covid-19 pandemic with an approach to analysis of the supply and income of informal workers. Informal workers have responded significantly to the impact of the pandemic on declining supply and income. The greatest impact of the pandemic was felt by informal workers in the non-agricultural sector, followed by male informal workers and informal workers living in urban areas.
Kinerja guru matematika SMP dalam membangun minat dan motivasi belajar siswa
Authors: Tambunan Hardi 
Published: May 2022

Penelitian ini bertujuan untuk mendeskripsikan kinerja guru matematika SMP dalam membangun minat dan motivasi belajar siswa. Penelitian ini adalah penelitian ex post facto. Populasi mencakup semua siswa kelas 8 SMP di 4 sekolah negeri dan 3 sekolah swasta di Sumatera Utara, dan sampel diambil secara acak sebanyak 243 siswa. Instrumen penelitian menggunakan angket, dan data penelitian dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa secara umum kinerja guru matematika dalam membangun minat belajar siswa berada pada kategori cukup. Ketika membangun minat belajar siswa, dilihat dari aspek menyampaikan tujuan pembelajaran, menjelaskan manfaat pembelajaran, dan pendekatan pembelajaran yang digunakan, kinerja guru berada pada kategori cukup, sedangkan dalam hal membuat siswa senang belajar kinerja guru masih berada pada kategori kurang baik. Kinerja guru matematika dalam membangun motivasi belajar siswa juga berada pada kategori cukup. Ketika membangun motivasi belajar siswa, kinerja guru dalam menjelaskan pentingnya belajar keras, melaksanakan ujian remedial, memberitahukan hasil ujian, dan memberikan pujian berada pada kategori cukup, sedangkan kinerja dalam membuat kompetisi di kelas berada pada kategori kurang baik AbstractThis study aimed to describe junior high school mathematics teachers’ performance in building student interest and motivation. This study was an ex post facto research. The population included all eighth-grade students of junior high schools from four public schools and three private schools in Sumatera Utara, Indonesia, and 243 students were randomly selected as samples. The instrument used a questionnaire, and the data were analyzed descriptively. The results showed that, in general, mathematics teachers’ performance in building students’ interest in learning was in the moderate category. In building students’ interest in learning, teachers’ performance conveying learning objectives, explaining the benefits of learning, and the learning approach used, teachers’ performance was in the moderate category, while in terms of making students happy to learn, teacher performance was still in the poor category. The performance of mathematics teachers in building students’ motivation was also in the moderate category. In building students’ motivation, teachers’ performance in explaining the importance of studying hard, administrating remedial exams, notifying test results, and giving praise were in the moderate category, while making class competition is in the poor category.
Identifikasi proses berpikir siswa dalam menyelesaikan masalah aljabar dengan menggunakan representasi graf
Authors: Lailiyah Siti , Kusaeri Kusaeri , Rizki Wenda Yulian 
Published: May 2022

Representasi graf banyak digunakan, salah satunya untuk menggambarkan proses berpikir siswa. Caranya dengan melihat hubungan antara langkah penyelesaian satu dengan lainnya dalam menyelesaikan masalah matematika. Penelitian ini bertujuan untuk merepresentasikan proses berpikir siswa dalam menyelesaikan masalah aljabar dengan bantuan representasi graf. Subjek penelitian ini adalah 3 dari 38 siswa kelas IX-A SMP Negeri 26 Surabaya, yang diambil dengan teknik snowball sampling. Teknik pengumpulan data menggunakan metode wawancara berbasis tugas. Tugas atau masalah yang diberikan berupa dua soal open onded dan hasilnya dianalisis serta direpresentasikan melalui graf: graf pohon biner, graf pohon rentang, dan graf pohon keputusan. Hasil penelitian menunjukkan bahwa melalui graf pohon biner, representasi proses berpikir siswa masih sederhana dan tidak sistematis dengan langkah-langkah penyelesaian yang dilakukan masih sedikit. Melalui graf pohon rentang, proses berpikir siswa direpresentasikan secara praktis, lengkap, dan tepat. Melalui graf pohon keputusan, proses berpikir siswa direpresentasikan secara teratur, rinci, dan terurut. AbstractOne of the uses of graph representation was to describe students’ thinking. Processes by identifying the relationship between one completion step and another completion step in doing mathematics problems. This qualitative descriptive research aimed to describe the representation of students’ thinking processes in solving algebraic questions with the help of graph representation. The subjects of this study were 3 from 38 students of class IX-A at SMP Negeri 26 Surabaya, Indonesia selected through snowball sampling. Data was collected from task-based interview methods. The task or problem given was two open-ended questions and the results were analyzed as well as represented through graphs: binary tree graph, spanning tree graph, and decision tree graph. The results showed that through the binary tree graph, the representations of students’ thinking processes were still simple and not systematic with few steps to complete. Through the spanning tree graph, students’ thinking processes were represented practically, completely, and precisely. Through the decision tree graph, students’ thinking processes were represented in an orderly, detailed, and consecutive.
Analisis kemampuan berpikir kritis ditinjau dari gaya belajar matematika siswa
Authors: Setiana Dafid Slamet , Purwoko Riawan Yudi 
Published: May 2022

Penelitian ini bertujuan untuk mendeskripsikan kemampuan berpikir kritis ditinjau dari gaya belajar matematika siswa. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Subjek penelitian adalah siswa kelas XII SMA Negeri Punung, Kabupaten Pacitan. Subjek penelitian sebanyak enam siswa dengan masing-masing dua siswa untuk gaya belajar visual, auditorial, dan kinestetik. Data penelitian diambil melalui angket gaya belajar, tes kemampuan berpikir kritis, dan wawancara. Data angket dianalisis untuk menentukan jenis gaya belajar siswa, sedangkan data hasil tes dianalisis berdasarkan aspek kemampuan berpikir kritis matematis yaitu FRISCO – Focus, Reason, Inference, Situation, Clarify, and Overview. Hasil penelitian menunjukkan bahwa kemampuan berpikir kritis siswa pada masing-masing gaya belajar memiliki tingkatan yang berbeda. Siswa dengan gaya belajar visual memiliki kemampuan berpikir kritis pada kriteria sangat baik, siswa dengan gaya belajar auditorial memiliki kemampuan berpikir kritis pada kriteria cukup, sedangkan siswa dengan gaya belajar kinestetik memiliki kemampuan berpikir kritis pada kriteria baik. Namun demikian ketiganya mempunyai potensi kuat untuk mengembangkan kemampuan berpikir kritis dalam matematika melalui stimulasi dari guru. Analysis of critical thinking skills in terms of students' mathematics learning stylesAbstractThis study aimed to describe critical thinking skills in terms of students’ mathematics learning styles. It was a qualitative descriptive study. The study subjects were twelfth-grade students of SMA Negeri Punung (Public Senior High School), Pacitan Regency, Indonesia. The subjects were six students, with two students each for visual, auditory, and kinesthetic learning styles. The data were taken through learning style questionnaires, critical thinking skills tests, and interviews. The questionnaire data were analyzed to determine the type of student learning style, while the test result data were analyzed based on aspects of mathematical critical thinking skills, namely FRISCO – Focus, Reason, Inference, Situation, Clarify, and Overview. The results showed that students’ critical thinking skills in each learning style had different levels. Students with visual learning styles have the critical thinking skills on very good criteria, students with auditory learning styles have the critical thinking skills on moderate criteria, while students with kinesthetic learning styles have the critical thinking skills on good criteria. However, all three have strong potential to develop critical thinking skills in mathematics through stimulation from the teacher.
Pengembangan film animasi aritmetika sosial berbasis ekonomi syariah untuk meningkatkan minat belajar siswa MTs
Authors: Safitri Wilda Yumna , Retnawati Heri , Rofiki Imam 
Published: May 2022

Penelitian ini bertujuan untuk menghasilkan film animasi aritmetika sosial berbasis ekonomi syariah yang valid, praktis, dan efektif untuk meningkatkan minat belajar siswa. Penelitian pengembangan ini menggunakan model Plomp yang terdiri dari tiga fase, yaitu fase penelitian pendahuluan, fase pembuatan prototype, dan fase penilaian. Uji coba prototype dilakukan kepada 21 siswa kelas VIII MTs di Sidoarjo, Indonesia. Instrumen penelitian terdiri dari lembar validasi ahli untuk menilai kevalidan, angket respons siswa untuk menilai kepraktisan, dan angket minat belajar siswa untuk menilai keefektifan film animasi. Penelitian ini menghasilkan film animasi aritmetika sosial berbasis ekonomi syariah untuk meningkatkan minat belajar siswa MTs terhadap pembelajaran matematika yang terintegrasi dengan ilmu keislaman. Meskipun peningkatan minat belajar siswa masih tergolong rendah, namun secara keseluruhan film animasi yang dikembangkan dinilai valid, praktis, dan efektif, sehingga layak digunakan dalam pembelajaran matematika di MTs. Development of social arithmetic animation film based on sharia economic to increase MTs students' interest in learningAbstractThis study aimed to produce an animated film of social arithmetic based on sharia economics that was valid, practical, and effective to increase students’ interest. The study was development research using Plomp’s model, which consisted of three stages: the preliminary research stage, the prototyping stage, and the assessment stage. Prototype trials were conducted on grade-eight students (n = 21) of MTs (Islamic Junior High School) in Sidoarjo, Indonesia. The instruments consisted of the expert validation sheet to assess the validity, the students' response questionnaire to assess the practicality, and the students' interest questionnaire to assess the effectiveness of the animated film. This study produced an animated film of social arithmetic based on sharia economics to increase MTs students' interest in learning mathematics integrated with Islamic science. Although the increase in student interest in learning was still low, overall, the animated film developed was considered valid, practical, and effective, so it was proper to use in mathematics learning in MTs.
Deep Neural Networks for Simultaneously Capturing Public Topics and Sentiments During a Pandemic: Application on a COVID-19 Tweet Data Set
Authors: Boukobza Adrien , Burgun Anita , Roudier Bertrand , Tsopra Rosy 
Published: May 2022

Background
Public engagement is a key element for mitigating pandemics, and a good understanding of public opinion could help to encourage the successful adoption of public health measures by the population. In past years, deep learning has been increasingly applied to the analysis of text from social networks. However, most of the developed approaches can only capture topics or sentiments alone but not both together.

Objective
Here, we aimed to develop a new approach, based on deep neural networks, for simultaneously capturing public topics and sentiments and applied it to tweets sent just after the announcement of the COVID-19 pandemic by the World Health Organization (WHO).

Methods
A total of 1,386,496 tweets were collected, preprocessed, and split with a ratio of 80:20 into training and validation sets, respectively. We combined lexicons and convolutional neural networks to improve sentiment prediction. The trained model achieved an overall accuracy of 81% and a precision of 82% and was able to capture simultaneously the weighted words associated with a predicted sentiment intensity score. These outputs were then visualized via an interactive and customizable web interface based on a word cloud representation. Using word cloud analysis, we captured the main topics for extreme positive and negative sentiment intensity scores.

Results
In reaction to the announcement of the pandemic by the WHO, 6 negative and 5 positive topics were discussed on Twitter. Twitter users seemed to be worried about the international situation, economic consequences, and medical situation. Conversely, they seemed to be satisfied with the commitment of medical and social workers and with the collaboration between people.

Conclusions
We propose a new method based on deep neural networks for simultaneously extracting public topics and sentiments from tweets. This method could be helpful for monitoring public opinion during crises such as pandemics.