bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Karakteristik Ibu dengan Sikap Responsif Anak
Authors: Nurdiantami Yuri , Shabriyyah Nahda Fini , Riyanti Febilla Dwinanda , Muhammad Ridho Fadhil , Muhayati Diva Annisa 
Published: July 2022

Sikap responsif seorang anak terhadap ibunya merupakan salah satu sikap yang akan terbentuk melalui pola pengasuhan. Pola asuh tidak terlepas dari karakterstik dalam diri orang tua, terlebih ibu. Karakteristik tersebut memberi warna dalam pola asuh yang diterapkan pada anak. Berdasarkan hal tersebut, studi ini bertujuan untuk meneliti hubungan antara karakteristik ibu dengan sikap responsif pada anak. Studi ini menggunakan desain penelitian cross sectional. Pengumpulan data dilakukan dengan metode online survey dan wawancara yang disertai observasi. Subjek studi sebanyak 88 responden. Sikap responsif anak dilihat dari reaksi yang kuat selama berinteraksi dengan ibu maupun bertutur atau berceloteh dengan ibu atau pengasuh. Sebagian besar responden berusia 18-35 tahun (64,8%), memiliki pendidikan yang rendah dan menengah (85,2%), dan tidak bekerja (84,1%). Hasil uji chi square dan regresi logistik sederhana menunjukkan hubungan yang bermakna secara statistik antara status pekerjaan ibu dengan sikap responsif anak, dimana anak dari ibu yang bekerja memiliki kemungkinan lebih besar untuk bersikap responsif, baik dilihat dari reaksi yang kuat selama interaksi (OR=3,9; 95% CI=0,998-15,013; p<0,05) maupun bertutur kata dalam 5 detik setelah perkataan ibu (OR=3,5; 95% CI=0,995-12,081; p<0,05). Pada penelitian ini, tidak terbukti adanya hubungan antara usia ibu (p=0.803) dan pendidikan ibu (p=0.066) dengan sikap responsif anak. Dari hasil studi ini, disarankan bagi ibu yang bekerja untuk mengatur waktu supaya tetap kondusif dalam mengasuh anak karena status ibu bekerja mempengaruhi sikap responsif anak.
Frekuensi dan Mortalitas Pasien Sepsis dan Syok Septik di ICU Rumah Sakit Swasta Tipe B, di Tangerang Selatan
Authors: Wicaksono Abioso , Adisasmita Asri C. , Harijanto Eddy 
Published: July 2022

Syok septik, yang didefinisikan sebagai sepsis dengan abnormalitas pada system sirkulasi and selular atau metabolic, masih merupakan salah satu penyebab kematian di Intensive Care Unit (ICU) secara global (20%). Studi kros-seksional ini bertujuan untuk mengetahui frekuensi, faktor risiko syok septik dan mortalitas pada pasien sepsis yang dirawat di ICU di Indonesia. Sampel dikumpulkan dari RS tipe B di Tangerang Selatan, Banten tahun 2020. Data yang dikumpulkan terdiri dari tempat infeksi, komorbiditas: Diabetes Melitus (DM) II, hipertensi, penyakit paru obstruksi kronis dan penyakit ginjal Kronis, asal unit sebelum masuk ICU, Glasgow Coma Score (GCS), acute respiratory distress syndrome (ARDS), lama rawat di ICU, syok septik dan mortalitas. Prevalens, frekuensi faktor risiko untuk syok septik dan kematian secara umum diantara pasien sepsis di ICU diukur dengan persentase, dan untuk perbedaan karakteristik diukur menggunakan chi-square untuk kemaknaannya. Terdapat 110 pasien di ICU dengan diagnosis sepsis di tahun 2020. Sumber infeksi tertinggi adalah pulmoner (39,1%) dan intra-abdominal (31,8%). Komorbiditas tersering pada pasien sepsis adalah hipertensi (53.6%), diikuti oleh DM (44.5%). Mayoritas lama rawat di ICU adalah melebihi 7 hari (67.3%). Risiko terjadinya syok sepsis tertinggi didapatkan pada para pengguna BPJS1.53 (95%CI, 0.83-2.82), pasien dengan gizi lebih: 1.59 (95%CI, 0.63-4.03), pasien alih rawat dari ruang rawat non-intensif: 2.28 (95%CI, 1.19-4.35), penyakit paru obstruksi kronis: 1.95 (95%CI, 0.55-6.90), dan penyakit urogenital kronis.: 1.93 (95%CI, 0.78-4.78) dibandingkan dengan referensnya masing-masing. Penelitian serupa di negara LMIC diperlukan untuk mendapatkan informasi mengenai beban riel karena sepsis dan syok septik secara regional.
Evaluating the readability, quality and reliability of online patient education materials on post-covid pain
Authors: Ozduran Erkan , Büyükçoban Sibel 
Published: July 2022

Background
The use of the Internet to access healthcare-related information is increasing day by day. However, there are concerns regarding the reliability and comprehensibility of this information. This study aimed to investigate the readability, reliability, and quality of Internet-based patient educational materials (PEM) related to “post-COVID-19 pain.”

Methods
One-hundred websites that fit the purposes of the study were identified by searching for the terms “post-COVID-19 pain” and “pain after COVID-19” using the Google search engine on February 24, 2022. The website readability was assessed using the Flesch Reading Ease Score (FRES), Flesch–Kincaid Grade Level (FKGL), Simple Measure of Gobbledygook (SMOG), and Gunning FOG (GFOG). The reliability, quality, and popularity of the websites were assessed using the JAMA score, DISCERN score/Health on the Net Foundation code of conduct, and Alexa, respectively.

Results
Upon investigation of the textual contents, the mean FRES was 51.40 ± 10.65 (difficult), the mean FKGL and SMOG were 10.93 ± 2.17 and 9.83 ± 1.66 years, respectively, and the mean GFOG was 13.14 ± 2.16 (very difficult). Furthermore, 24.5% of the websites were highly reliable according to JAMA scores, 8% were of high quality according to GQS values, and 10% were HONcode-compliant. There was a statistically significant difference between the website types and reliability (p = 0.003) and quality scores (p = 0.002).

Conclusion
The readability level of PEM on post-COVID-19 pain was considerably higher than grade 6 educational level, as recommended by the National Institutes of Health, and had low reliability and poor quality. We suggest that Internet-based PEM should have a certain degree of readability that is in accordance with the educational level of the general public and feature reliable content.
Mouse Auxiliar Distribuidor de Carga de Trabalho na Interação com um Computador Pessoal para duas Mãos
Authors: Raymundo Fabrício de Andrade , Andrade Marcelo Borges de , Bezerra Marcus Vinícius Lopes , Oliveira Marina Couto Giordano de , Lopes Sânya Léa Alves Rocha , Martin Adriana Regina , Nascimento Paulo Gustavo Barboni Dantas 
Published: July 2022

O presente artigo trata-se de uma análise da tecnologia protegida por pedido de patente de invenção de um dispositivo apontador, mais conhecido como mouse, que se propõe a permitir a distribuição da carga de trabalho na interação com um computador pessoal para as duas mãos. Objetivou-se verificar o estado da arte, o nível de maturidade tecnológica e o potencial mercadológico dessa invenção, a fim de analisar seu desenvolvimento, bem como suas rotas tecnológicas. Para tal, foi realizado um levantamento de dados nas bases internacionais Orbit – da Orbit Intelligence –, United States Patent and Trademark Office (USPTO), Espacenet – do European Patent Office (EPO) –, Patentscope – da World Intellectual Property Organization (WIPO) –, Web of Science – da Thomson Reuters Scientific – e na base nacional do Instituto Nacional de Propriedade Industrial (INPI).
Empreendedorismo e Transferência Tecnológica: uma análise da atuação das incubadoras de empresas da Amazônia
Authors: Oliveira Márcio Luis  de , Simões Filho Cirilo , Mendonça Cláudio Márcio Campos de , Lima Júnior Walter Teixeira 
Published: July 2022

Transferência tecnológica (TT) é um processo de troca de conhecimentos e habilidades tecnológicas entre organizações. Há diversos instrumentos para a viabilização da TT, entre elas as incubadoras de empresas, organismos que têm como missão o fortalecimento da cultura empreendedora, associadas à política de inovação das ICTs. Assim, este artigo objetivou analisar como as incubadoras de empresas da Amazônia atuam para apoiar a transferência das tecnologias dos empreendimentos incubados. A abordagem ao problema foi qualitativa e quantitativa, com estudo de casos. Utilizou-se como referência as incubadoras membros da Associação Nacional de Entidades Promotoras de Empreendimentos Inovadores (ANPROTEC). Os sites institucionais das incubadoras pouco têm detalhado como funcionam os processos de apoio à transferência tecnológica e também a descrição dos instrumentos de negociação, valoração e prontidão tecnológica (TRL). Um ponto relevante refere-se ao uso de parcerias no processo de TT como solução para limitações das ICTs amazônicas.
Genetics of Human Character and Temperament
Authors: Cloninger C Robert , Zwir Igor 
Published: July 2022

AbstractPersonality is the way individuals learn to shape and adapt to changing conditions. The character domain of personality is what people make of themselves intentionally, whereas temperament involves automatic emotional reactivity. Prior studies assuming genes act independently failed to identify most personality‐related genes. Therefore, we used machine learning to identify naturally occurring clusters of genes. In independent genome‐wide association studies from different cultures, we found many replicable multigene clusters among 972 genes that accounted for nearly all the heritability expected from twin studies. Temperament depended on multigene clusters in molecular systems for associative conditioning of habits and emotional reactivity. Character depended on clusters in intentional networks: self‐control of goals via Inositol–Calcium signalling, and self‐awareness of values via long‐non‐coding RNAs unique to modern humans. These three systems of learning and memory allow the integration of habits, goals, and values via the regulation of gene expression to maintain healthy functioning despite variable environmental conditions.Key ConceptsThe ‘Hidden Heritability Problem’ with complex phenotypes.Human personality is moderately heritable (∼50%) according to many twin and adoption studies, but few of the specific genes for personality were recognised by studies that assumed the genes involved were acting independently.Human character and temperament have a complex architecture: the same gene or cluster of genes can be associated with multiple phenotypes, and different genes or clusters of genes can have the same phenotype.Empirical methods of pattern recognition based on machine learning allow efficient and replicable deconstruction of the complex architecture of human personality.Human personality is a complex phenotype with multiple components.The temperament domain of personality is the disposition of a person to learn how to behave, react emotionally and form attachments automatically by associative conditioning of their habits.Human character is the self‐regulatory domain of personality – that is, the way a person shapes and adapts their goals and values to ever‐changing external and internal conditions.Human character and temperament are each comprised of multiple components that depend on how people function in different situations and environments.Character and Temperament involve adaptive processes of learning, not fixed traits.Human personality is the integrated expression of three genotypic systems that regulate learning and memory by associative conditioning, intentional self‐control and creative self‐awareness.Most of the genes for personality are unique to a single learning system, but there is sufficient overlap to permit integrated functioning.The integration of human character and temperament allows flexible regulation of gene expression to maintain healthy functioning despite variable environments.
Stroke
Authors: Auer Roland N , Meher Vedashree R 
Published: July 2022

Abstract

Blood vessels supplying the brain can either be blocked or broken, giving rise to the two kinds of stroke: infarcts and haemorrhages. The symptoms and their permanence depend on how much brain tissue is destroyed and in what location.

Key Concepts

Stroke is the third leading cause of death.

There are two types of strokes: haemorrhagic or ischemic.

The occlusive substance in ischemia arises from carotid atherosclerosis or underlying heart disease.

‘Time is Brain’: treating a patient in a timely manner is crucial for preventing increased neuronal loss.

tPA is an effective clot‐busting drug, however, it can only be administered within 4.5 h of symptom onset.

Endovascular therapy, a mechanical clot‐retrieving technique, is proven to be far more superior to tPA treatment.

Brain swelling from oedema occurs secondary to stroke.

There are two types of oedema that occurs poststroke, vasogenic or cytotoxic and are known to partly arise from the cerebrospinal fluid in and around the brain.

Strokes can lead to severe long‐term motor, sensory and cognitive impairments.

Stroke rehabilitation remains essential for relearning skills and regaining functional independence poststroke.
Transfer RNA
Authors: Goldman Emanuel 
Published: July 2022

Abstract

Transfer ribonucleic acid (tRNA) is the class of molecules that decode the genetic code and link the coded information to their attached amino acids. The amino acids are attached to the tRNAs by a class of enzymes known as aminoacyl‐tRNA synthetases. Specificity of cognate tRNAs with aa‐tRNA‐synthetases and amino acids is responsible for the faithful implementation of coding information in genes. Amino acids are delivered by tRNAs to the ribosome to become constituents of the protein specified by the gene. tRNAs are highly structured and contain a large amount of posttranscriptional modifications of nucleic acid bases, many of which are known to have considerable impact on function. tRNAs also have roles in the regulation of translation and have been co‐opted for roles in pathways unrelated to translation, for example, as primers for RNA virus nucleic acid replication.

Key Concepts

tRNAs are the linchpin between the amino acids that comprise a protein and the genetic instructions for design of the protein.

While all tRNAs conserve a generic structure, specific variations in primary sequence and modified nucleotides distinguish one tRNA from another.

There are a lot of different posttranscriptional modifications in tRNA, which led Crick to comment that it was as if tRNA was a nucleic acid masquerading as a protein.

The generic tRNA structure is in the form of a cloverleaf in two dimensions, and an L‐shaped molecule in three dimensions, with the acceptor end and the anticodon at opposite ends of the structure.

Specific amino acids are attached to cognate tRNAs by cognate aminoacyl (aa)‐tRNA synthetases, mediated by identity elements in individual tRNAs.

Amino acids are always attached to the 3′ terminal adenosine in the universal CCA sequence in the acceptor stem of the molecule.

Quality‐control mechanisms exist to maintain the accurate incorporation of amino acids into the growing protein chain.

tRNAs deliver their attached amino acids to the codon‐programmed A (aminoacyl) site on the ribosome.

Anticodons in individual tRNAs basepair in an antiparallel fashion to codon triplets in the A site of the ribosome.

Flexibility, or ‘wobble’, occurs in base pairing between the 3rd code letter with the 5′ anticodon nucleotide.
Commissioning and validation of RayStation treatment planning system for CyberKnife M6
Authors: Gondré Maude , Conrad Mireille , Vallet Véronique , Bourhis Jean , Bochud François , Moeckli Raphaël 
Published: July 2022

AbstractBackgroundRaySearch (AB, Stockholm) has released a module for CyberKnife (CK) planning within its RayStation (RS) treatment planning system (TPS).PurposeTo create and validate beam models of fixed, Iris, and multileaf collimators (MLC) of the CK M6 for Monte Carlo (MC) and collapsed cone (CC) algorithms in the RS TPS.MethodsMeasurements needed for the creation of the beam models were performed in a water tank with a stereotactic PTW 60018 diode. Both CC and MC models were optimized in RS by minimizing the differences between the measured and computed profiles and percentage depth doses. The models were then validated by comparing dose from the plans created in RS with both single and multiple beams in different phantom conditions with the corresponding measured dose. Irregular field shapes and off‐axis beams were also tested for the MLC. Validation measurements were performed using an A1SL ionization chamber, EBT3 Gafchromic films, and a PTW 1000 SRS detector. Finally, patient‐specific QAs with gamma criteria of 3%/1 mm were performed for each model.ResultsThe models were created in a straightforward manner with efficient tools available in RS. The differences between computed and measured doses were within ±1% for most of the configurations tested and reached a maximum of 3.2% for measurements at a depth of 19.5‐cm. With respect to all collimators and algorithms, the maximum averaged dose difference was 0.8% when considering absolute dose measurements on the central axis. The patient‐specific QAs led to a mean result of 98% of points fulfilling gamma criteria.ConclusionsWe created both CC and MC models for fixed, Iris, and MLC collimators in RS. The dose differences for all collimators and algorithms were within ±1%, except for depths larger than 9 cm. This allowed us to validate both models for clinical use.
Controller parameterization and bias current reduction of active magnetic bearings for a flexible and gyroscopic spindle
Authors: Franz Daniel , Jungblut Jens , Rinderknecht Stephan 
Published: July 2022

AbstractA magnetically levitated spindle was designed for fatigue testing of cylinders made of fiber reinforced plastic. In these fatigue tests, the speed of the cylinders is varied cyclically between 15,000 and 30,000 rpm until their mechanical failure occurs. Several eigenfrequencies have to be passed to reach the operational speed range. During long‐term operation, the rotor of the spindle is prone to overheating due to various losses. One way of reducing the rotor temperature is to decrease the bias current of the radial active magnetic bearings. Since the bias current influences the dynamic behavior of the system, the control of the bearings has to be adapted as well. This article describes a controller design for the system with different bias currents to determine the smallest usable bias current. A detailed model of the plant is developed, which is then used to optimize the parameters of the utilized controller with a predefined structure using the weighted norm as the objective function. Since the rotor is highly gyroscopic, its eigenfrequencies change with the rotational speed. To ensure that the system meets certain robustness criteria at all rotational speeds, the parameters of the controller are simultaneously optimized for the plant model at different speeds. This approach leads to a controller which can be used in the entire speed range without the need for gain scheduling. The functionality of the controller and the influence of the bias current on the rotor temperature are investigated through measurements.
Immunostimulant In Situ Hydrogel Improves Synergetic Radioimmunotherapy of Malignant Glioblastoma Relapse Post‐Resection
Authors: Sun Shuo , Gu Wei , Wu Haisi , Zhao Qianqian , Qian Shiyu , Xiao Hong , Yang Kun , Liu Jian , Jin Yu , Hu Chupeng , Gao Ye , Xu Huae , Liu Hongyi , Ji Jing , Chen Yun 
Published: July 2022

AbstractTumor recurrence remains the major cause of management failure after surgical resection of glioblastoma (GBM). Immunotherapy has the potential to effectively eradicate tumors and trigger immune memory to prevent tumor recurrence but not improve the outcomes of GBM patients. Here, an injectable, reactive oxygen species‐degradable therapeutic hydrogel (ADU‐AAV‐PD1@Gel), capable of sustained local release of soluble PD‐1 (sPD‐1) and stimulator of interferon gene (STING) agonist ADU‐S100 (ADU), is developed and applied in a GBM surgical resection model. Adeno‐associated virus serotype 9 is employed to stably express sPD‐1 blocking the PD‐1/PD‐L1 pathway. Concomitantly, the released ADU activates the STING pathway to improve tumor immunogenicity and response to therapy. This therapeutic hydrogel combined with radiotherapy (RT) effectively promotes sustained T cells infiltration and restores T cells effector function, which exhibits a robust antitumor immune response and significantly suppresses tumor growth. Moreover, ADU‐AAV‐PD1@Gel combined with RT treatment can also induce a long‐term immune memory to prevent GBM recurrence. As a result, ADU‐AAV‐PD1@Gel provides a novel strategy for effective radioimmunotherapy of GBM relapse post‐resection.
Enabling Long‐Term Cycling Stability Within Layered Li‐Rich Cathode Materials by O2/O3‐Type Biphasic Design Strategy
Authors: Cao Xin , Sun Jianming , Chang Zhi , Wang Pengfei , Yue Xiyan , Okagaki Jun , He Ping , Yoo Eunjoo , Zhou Haoshen 
Published: July 2022

AbstractTypical Li‐rich layered oxides are widely regarded as promising cathode candidates for high‐energy‐density Li‐ion batteries because of additional output capacities boosted by oxygen redox activities. However, its commercialized applications are hindered by serious capacity loss and voltage decay related to structural degradation upon cycling. Herein, a Co/Ni‐free biphasic O2/O3‐type layered cathode material is proposed, Li0.9[Li0.3Mn0.7]O2, which has been successfully prepared by the Li+/Na+ion‐exchange strategy and characterized by the XRD Rietveld refinement and SAED as well as HRTEM analyses. O2/O3‐type layered cathode material with an approximate composition of 81% O2 and 19% O3 phases are confirmed. Furthermore, the biphasic cathode exhibits a high discharge capacity of 232 mAh g−1with capacity retention of 88.1% after 500 cycles at a current density of 200 mA g−1. That is, volume changes of the O3‐type phase are effectively restricted during Li+(de)intercalations, further enhancing the structural stability and suppressing the formation of spinel phase due to the biphasic structural design. Altogether, these findings prove the biphasic structural design is a feasible strategy to achieve Li‐rich cathode materials with high capacity and long‐term cycle stability.
Donor Engineering Tuning the Analog Switching Range and Operational Stability of Organic Synaptic Transistors for Neuromorphic Systems
Authors: Zhao Yanfei , Su Chaohui , Shen Guangyue , Xie Zhichao , Xiao Wei , Fu Yujun , Inal Sahika , Wang Qi , Wang Yazhou , Yue Wan , McCulloch Iain , He Deyan 
Published: July 2022

AbstractOrganic artificial synapses are becoming the most desirable format for neuromorphic computing due to their highly tunable resistive states. However, repressively low analog switching range, inferior memory retention, and operational instability greatly hinder the further development of organic synapses. Herein, two donor‐acceptor copolymers consisting of electron‐deficient isoindigo coupled with variable donating moieties for three‐terminal organic synaptic transistors (TOSTs) are reported. It is found that the synaptic function and device stability of TOSTs are significantly improved by enhancing the electron‐donating strength of donor units. Polymer alkylated isoindigo‐bis‐ethylenedioxythiophene exhibits high analog switching range of 170 ×, two orders of magnitude higher than that of normal organic neuromorphic devices. They also demonstrate excellent memory retention of over 5 × 103 s, low switching energy of 13 fJ, and ultrahigh operational stability with 99% of its original current after 100 000 write‐read events in air. Furthermore, the high viability of strong donor strategy is showcased by demonstrating flexible TOSTs with stable synaptic function after repeated mechanical bending as well as organic synapses capable of simulating image information processing. Overall, this work highlights the advantages of the strong donor functionalization strategy to boost the synaptic performance and device stability of TOSTs.