bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroencephalogram in Children who Experienced First Unprovoked Seizure
Authors: Vanadia Arinda Putri Auna , Gunawan Prastiya Indra , Abdurachman Abdurachman , Utomo Martono Tri , Hidayati Hanik Badriyah 
Published: August 2022

Highlight:

Epiletiform abnormalities on the EEG provide additional clinical infromation about seizures
The majority of patients who have a first unprovoked seizure have an abnormal EEG (Abnormal II).
Using EEG as a supporting diagnostic tool in patients experiencing their first unprovoked seizures may provide more information to improve treatment

ABSTRACT
Introduction: The first unprovoked seizure is defined as a series of seizures that occur within 24 hours and are followed by recovery of consciousness with unknown triggering causes such as head trauma, central nervous system infections, tumors, or hypoglycemia. The first unprovoked seizure is a thing that cannot be underestimated. According to a previous study, less than half of those who experience their first unprovoked seizure will have another. An electroencephalogram (EEG) is one of the supporting examinations for the first unprovoked seizure. Objective: This study aims to determine the EEG as the first unprovoked seizure supporting examination. Methods: This is a retrospective, descriptive, observational study with sampling from the patient's medical record at Dr. Soetomo General Hospital Surabaya from January 2017 to December 2018 based on predetermined inclusion and exclusion criteria. Results: The EEG results in children who experienced their first unprovoked seizure were more abnormal (52.9%) than normal (47.1%), with an abnormal EEG breakdown of abnormal II (17.6%) and abnormal III (35.3%). There were no patients in this study who had EEG abnormal I. All patients with EEG abnormal II (17.6%) had an intermittent slow EEG waveform, while all patients with EEG abnormal III (35.3%) had a sharp waveform. The most common location of EEG wave abnormalities was temporal (55.6%). Conclusion: In the first unprovoked seizure, an EEG examination can assist clinicians as a seizure diagnostic assistant tool. It is hoped that the results of the EEG can provide better management of the first unprovoked seizure.
Description of Stroke Patients with History of Smoking Activities
Authors: Sugianto Paulus , Abdillah Fatih Nugraha , Marhana Isnin Anang , Fidiana Fidiana 
Published: August 2022

Highlight:

Smoking raises the risk of cardiovascular disease, which can lead to stroke.
A total of 33 stroke patients were selected from 579 samples. The results show some tendencies.
The tendency of stroke patients with a history of activity to smoke can be explained for a number of reasons.

ABSTRACT
Introduction: Smoking is a habit of Indonesian society and can be found in many places. Smoking increases the risk of cardiovascular problems, which can lead to stroke. Objective: Provides an overview of stroke patients who smoke from January to December 2020. Methods: This retrospective, descriptive research used medical records and extra data from telephone interviews with patients. A non-probability purposive sampling strategy with a total sampling method is used in this investigation. The observed variables include age, gender, number of cigarettes consumed per day, length of smoking history, type of stroke, and comorbidity. Results: The sample consisted of 33 participants chosen among 579 stroke patients. The age range of 56–65 (39.4%) was found to be the most prevalent in the 33 samples, and the sex group was dominated by men (100%). Then, for the smoking habit, the highest number of cigarettes consumed per day was dominated by the group of 9-16 cigarettes per day (45.46%). The group dominates the long smoking history with a smoking history of 30-50 years (42.43%). Ischemic stroke, also known as cerebral infarction, was the most common type (78.79%) among the samples. Of the 33 samples of stroke patients who smoked, 4 (12.12%) experienced comorbidities, including coronary heart disease, diabetes mellitus, and essential thrombocytosis. Conclusion: Several factors describe the tendency of stroke patients with a smoking history.
APPROACH SELECTION METHOD FOR PROJECT PORTFOLIO MANAGEMENT AND ITS APPLICATION
Authors: Kononenko Igor , Kpodjedo Maximilien 
Published: August 2022

Project portfolio management has evolved in recent decades from an empirical field to a field with advanced management technologies, including the active use of information technology. A number of standards and guidelines for project portfolio management have been created. Many dozens of specialized software tools have been developed. The effectiveness of an organization's project portfolio management significantly depends on the chosen management approach, as well as the level of use of project portfolio management capabilities. The level of utilization of project portfolio management capabilities is the level of maturity of an organization in this area. The aim of the article is to apply the method of project portfolio management approach selection. The article proposes to carry out the selection of a project portfolio management approach by solving a two-criteria problem. The first criterion is the risks inherent in this approach in the management of the organization's project portfolio under specific conditions. The less these risks, the more qualitative approach is applied. The second criterion - the costs of applying the evaluated approach. The application of the proposed method to improve project portfolio management in one of the technical universities in Ukraine was considered. Risks from non-performance or imperfect performance of portfolio management processes at the university were assessed. We also assessed the existing costs of managing the portfolio of projects. To improve the quality of management at the university, it is advisable to improve the execution of portfolio management processes and implement those processes that are not yet performed. This can be done by implementing a computerized portfolio and project management system for the university. Jira Portfolio Commercial can be used as such a system. With the use of computerization, new processes for project portfolio management will appear. For a number of existing processes in the organization, employee payroll costs will be reduced. For many processes, risks from non-performance or imperfect execution will be reduced. Computerization of project portfolio management will enable to reduce management costs by 1.8% and risks by 49.4%, i.e. almost by half.
CHARACTERISTICS OF ECOLOGISTIC SYSTEMS PROJECTS
Authors: Kovtun Tetiana , Kovtun Dmytro 
Published: August 2022

The negative impact of human economic activity on the environment has led to an imbalance in the economic and environmental aspects of life and the emergence of a threat of disruption to the ecosystems state, which will make it impossible for humanity to fully exist on the planet. The solution to the problem is in the plane of ecologization all spheres of management, including logistics, which has a significant impact on the state of the environment. The change in the worldview paradigm led to the emergence of the ecologically oriented logistic system concept, by which it is proposed to understand the logistic system as a set of link elements interconnected in the process of management the direct and reverse logistic flows movement, taking into account the eco-destructive impact on the environment. The article proposes to consider the management of ecologistic systems through the prism of the project approach. The purpose of the article is to characterize projects of ecologistic systems. To achieve this goal, the following tasks were solved: specific features of ecologistic systems projects were investigated; the place of ecologistic systems projects in the classification of projects was determined; a classification of ecologistic systems projects has been developed. The characteristics of the ecologistic system project as a complex cybernetic system are given, the components of the project potential are determined. The place of micro-, meso- and macro-ecologistic systems projects in the general classification of projects and the classification of investment projects has been determined. The article presents the author's classification of ecologistic systems projects. As a basic classification criterion, it is proposed to use the reason for the implementation or the purpose of the project: the creation, development or functioning of an ecologistic system. Creation projects are classified according to the product being created. Development projects are classified depending on the object or subject of management, kind and type of development. Functioning projects include projects to create an ecologistic product.
Characteristics and Main Controls of Tectonic Fractures and Their Contribution to Deep Tight Reservoirs: A Case Study of the Huoshiling-Shahezi Formations in Gudian Half-Graben, Songliao Basin, China
Authors: Xu Litao , Wang Ren , Shi Wanzhong , Yu Gang , Zhang Xiaoming , Tang Daqing , Meng Fulin 
Published: August 2022

AbstractThe deep volcanic and clastic rocks in the Songliao Basin are typical tight reservoirs with ultralow porosity and permeability. Natural fracture determines the effective reservoirs in the deep strata. Integrated core and thin section observations, image logging, physical property measurement, X-ray diffraction, and seismic attribute analysis were applied to ascertain the characteristics and genetic mechanisms of the tectonic fractures in the Huoshiling-Shahezi Formations of the Gudian half-graben. The contribution of the fractures to deep tight reservoirs was also discussed. Results showed that tectonic fractures are mainly tension, shear, and slip fractures. The density of the fractures in andesitic tuffs with high clay minerals content is significantly higher than that in the other rock types. The main controls of the developmental degree of fractures are tectonism. Three sets of fractures were identified based on the genetic connection between fracture formation and tectonic stress. The NNW-trending tension fractures were formed in the syn-rift stage and successively extended in the post-rift stage. The regional compressional stress drove the formation of the NEE-trending shear fractures and NNW-trending “X” plane-conjugated shear fractures in the postextrusion stage. The averaged porosity and permeability of the reservoirs are generally less than 6.0% and lower than 0.06 mD. The pores can hardly independently provide migration pathways and storage spaces, but the fractures significantly improved the reservoir properties. The fractures were well developed in the regions near the Gudian fault, fault transfer zones, and volcanoes, indicating the distribution of potential reservoirs. Moreover, unraveling the types and orientations of the fractures will provide an essential basis for the analysis of hydrocarbon migration and hydraulic fracture treatments.
Patient-reported outcomes and healthcare resource utilization in systemic lupus erythematosus: Impact of disease activity
Authors: Touma Zahi , Costenbader Karen H. , Hoskin Ben , Atkinson Christian , Bell David , Massey Olivia , Berry Pamela , Karyekar Chetan S. 
Published: August 2022

Abstract
Background Limited real-world data exists on clinical outcomes in systemic lupus erythematosus (SLE) patients by SLE Disease Activity Index 2000 (SLEDAI-2K). We aimed to examine the association between SLEDAI-2K score and clinical, humanistic and economic outcomes in patients with SLE.MethodsRheumatologists from the United States of America and Europe provided real-world demographic, clinical, and healthcare resource utilization (HCRU) data for SLE patients. Patients provided self-reported outcome data, capturing their general health status using the EuroQol 5-dimension 3-level questionnaire (EQ-5D-3L), health-related quality of life using the Functional Assessment of Chronic Illness Therapy (FACIT) and work productivity using the Work Productivity and Activity Impairment questionnaire (WPAI). Low disease activity was defined as SLEDAI‑2K score ≤4 and ≤7.5mg/day glucocorticoids; patients not meeting these criteria were considered to have “higher” active disease. Data were compared between patients with low and higher disease activity. Logistic regression estimated a propensity score for SLE based on demographic and clinical characteristics. Propensity score matched analyses compared HCRU, patient-reported outcomes, income loss and treatment satisfaction in patients with low disease activity versus higher active disease.ResultsData from 296 physicians reporting on 730 patients (46 low disease activity, 684 higher active disease), and from 377 patients’ self-reported questionnaires (24 low disease activity, 353 higher active disease) were analyzed. (Flaring in the previous 12 months was 2.6‑fold more common among patients with higher versus low active disease.) EQ 5D‑3L utility index was 0.79 and 0.88 and FACIT-Fatigue scores were 34.78 and 39.79 in low versus higher active disease patients, respectively, indicating better health and less fatigue, among patients with low versus higher active disease. Absenteeism, presenteeism, overall work impairment, and total activity impairment were 47-, 2-, 2-.6- and 1–5-fold greater in patients with higher versus low disease activity. In the previous 12 months there were 28% more healthcare consultations and 3.4‑fold more patients hospitalized in patients with higher versus low disease activity.ConclusionCompared to SLE patients with higher active disease, patients with low disease activity experienced better health status, lower HCRU. less fatigue, and lower work productivity impairment, with work absenteeism being substantially lower in these patients.
DAG-based Blockchain for Trust Aware Load Balanced Routing and Lightweight
Authors: M Revanesh , V SRIDHAR , Acken John m 
Published: August 2022

Abstract
A wireless sensor network (WSN) is a staple network architecture that can be widely used to support diverse applications such as smart cities, smart homes, etc. The energy consumption and security have remained more perilous challenges in it. The blockchain is a potential solution for security provisioning in WSN. However, the classic blockchain has some problems as slow transaction processing and poor scalability. Hence, to address these issues the Directed Acyclic Graph-based Trust aware Load Balanced Routing (DAG-BTLBR) is proposed in WSN that constructs DAG for blocks. The proposed DAG-BTLBR is instigated with energy-efficient unequal cluster formation using Emperor Penguin Colony (EPC) algorithm. In this step, we mitigate the hotspot problem in WSN. An Adaptive Neuro-based Dual Fuzzy (ANDual Fuzzy) system is involved to find the secure and load-balanced route for packets transmission. ANDual Fuzzy is the combination of two fuzzy logic systems that will be in a parallel way. The DAG-based blockchain is used to store the transactions in the WSN. The lightweight authentication encryption scheme is designed for addressing data security requirements (data integrity, and confidentiality) and resource constraint issues of sensors. Initially, lightweight encryption is implemented by XTEA with Chaotic Map algorithm, whereas message authentication is implemented by Blake-256 algorithm. We computed the performance of our DAG-BTLBR model and compared it to the previous models by several evaluation criteria, which are implemented in NS3 (version 3.26). Our proposed model simulation results establish the performance and security improvements by minimizing end-to-end delay, time consumption, packet loss rate, and energy consumption, maximizing the throughput.
Ptbp1 knockdown failed to induce astrocytes to neurons in vivo
Authors: Yang Guixiang , Yan Zixiang , Wu Xiaoqing , Zhang Meng , Xu Chunlong , Shi Linyu , Yang Hui , Fang Kailun 
Published: August 2022

Abstract
Conversion of non-neuronal cells to neurons is a promising potential strategy for the treatment of neurodegenerative diseases. Recent studies have reported that shRNA-, CasRx-, or ASO-mediated Ptbp1 suppression could reprogram resident astrocytes to neurons. However, some groups have disputed the data interpretation of the reported neuron conversion events. These controversies surrounding neuron conversion may due to differences in the astrocyte fate-mapping systems. Here, we suppressed Ptbp1 using Cas13X, and labeled astrocytes with the HA tag fused to Cas13X (Cas13X-NLS-HA). Compared with the GFAP-driven tdTomato labeling system (AAV-GFAP::tdTomato-WPRE) in previous studies, we found no astrocyte-to-neuron conversion in mouse striatum via the HA-tagged labeling system. Our findings indicate Ptbp1 knockdown failed to induce neuron conversion in vivo.
Motion compensation algorithm for Multi-Orthogonal Signal Underwater Navigation System on moving platform
Authors: ZHANG Sen , ZHOU Chen Lin , YIN Tian Qi , WANG Ming Zhi , LIU Jia Huan 
Published: August 2022

Abstract
For the problem of positioning error due to the rotation of the platform when the transmitter of the Multi-orthogonal Signals Underwater Navigation System (MOSUNS) is mounted on a moving platform, this paper performs a motion error modeling. The relationship between the platform motion parameters (translation rate and rotation rate, etc.) and the difference of linear velocity among each transmitting elements and the resulting phase error is derived, and the relationship between MOSUNS positioning error and platform motion parameters is further deduced. Based on the moving platform positioning error model, a motion compensation algorithm is proposed to compensate the phase error caused by the platform rotation, and then compensate the positioning error. The motion error is quantified and analyzed by computer simulation, and the validity of the motion compensation algorithm is verified by simulation.
Microstructural Analysis of Sheet Hydroforming Process Assisted by Ultrasonic Vibration on Punch Radial in a Hydro-Mechanical Deep Drawing Die
Authors: Ghasemi Reza , Elyasi Majid , Baseri Hamid , Mirnia Mohammad Javad 
Published: August 2022

Abstract

Today, the use of sheet hydroforming methods in the conventional deep drawing process has significantly improved the formability of the sheet. However, due to the limitations of the sheet hydroforming process, new methods can be used in combination with it, such as ultrasonic-vibration-assisted forming. Many of the mechanical effects of ultrasonic vibration in the metal forming process are due to the metallurgical and structural impacts of the material, so to find the cause of the observed events, one must look at the microstructural interactions of materials. Therefore, the process of St14 sheet hydroforming with the assistance of ultrasonic vibration is investigated microstructurally in this paper. For this purpose, during the hydroforming drawing process, ultrasonic vibration was radially applied to the punch in a hydro-mechanical deep drawing die. Then the process parameters, including thickness, equivalent strain, grain size, and rotation at a selected point of the cross-section of the sample parts are compared in four modes of conventional deep drawing (CDD), hydroforming deep drawing (HDD), deep drawing assisted by ultrasonic vibration (UDD), and hydroforming deep drawing assisted by ultrasonic vibration (UHDD). Results showed that the application of ultrasonic vibrations in the sheet hydroforming process led to a significant reduction in thickness strain (as well as equivalent strain), increased grain length, and reduced rotation. This implies the positive impact of ultrasonic vibrations in the flow of materials is due to the reduction of friction and facilitates the movement of dislocations.
Formation of chloride deposits on Early Mars under acidic and reducing crustal conditions
Authors: Fernandez-Remolar David , Altermann Wladyslaw , Gomez-Ortiz David , Hynek Brian , Izawa Matthew , Hauber Ernst , Adeli Solmaz , Amils Ricardo , Huang Ting , Rosi Angelo Pio , Deit Laetitia Le 
Published: August 2022

Abstract

Orbital missions have shown that some regions of the ancient Martian crust contain hundreds of discrete terrains covered by chloride evaporites. In terrestrial evaporitic systems, aqueous precipitation typically begins with the deposition of carbonates, followed by sulfates, and finally chlorides, a depositional sequence that has not yet been found on Mars. Instead, sulfide deposits are always separated spatially from chlorides and appear younger. This temporal and spatial separation suggests two different depositional regimes. Here, we present a model driven by the Martian chlorine geochemical cycle that allows the formation of chlorides whilst simultaneously inhibiting sulfate and carbonate precipitation. In this model, the chlorides are formed under reducing and acidic conditions in two contrasting settings the hydrothermal alteration of the Martian crust associated with the formation of faults: by direct evaporation of water bodies fed by meteoric solutions (type 1) and by precipitation from ascending saline solutions along the tectonic conduits (type 2). Such processes were sustained under a relatively thick and reducing atmosphere (1-0.1 bar) similar to the predicted conditions for the early Earth. The crustal circulation of chloride-precipitating fluids may have been driven by tectonic suction and pumping processes.
Health risk and ecotoxicological assessment of water bodies and sediments in the vicinity of slag heap in Siechnice, Lower Silesia, Poland (Ocena ekotoksykologiczna wód i osadów dennych w okolicy hałdy pohutniczej w Siechnicach (Dolny Śląsk, Polska) wraz z oceną ryzyka zagrożenia zdrowotnego)
Authors: Zeynalli Farhad , Kapelko Kacper , Wróbel Magdalena , Rybak Justyna 
Published: August 2022

Abstract
The studies of the impact of post-metallurgical landfill were conducted in Siechnice near Wrocław, Lower Silesia. The samples of sediments and water were taken at different distances from the slag heap area. We assessed the metal concentrations in the samples, then ecotoxicological tests were conducted as well. Ostracodtoxkit F was performed to measure the toxicity of sediments. Daphtoxkit F magna and Algaltoxkit F tests were performed to evaluate water quality. 30% mortality rate of H. incongruens (Ostracodtoxkit F) was recorded in sediment studies in the closest site to the waste dump. The highest mortality rate of D.magna in 100% dilution after 48 hours was observed in water samples taken from the closest distance to slag heap, and the death rate did not exceed 50%, therefore it was not possible to establish LC50. The concentrations of selected heavy metals (Zn, Cu, Pb, Fe, Cr) were determined in sediment samples. It was found that the closest site to the landfill was moderately/heavily polluted with Cr according to LAWA classification. The health risk assessment of the sediments was estimated by calculating non-carcinogenic health risk such as Hazard Quotient (HQ), Hazard Index (HI); and carcinogenic risk - Excessive Risk of Cancer Development (ECR). Hazard Index (HI ing) for Cr was exceeding 1 for children, implying possible adverse health effects might occur. ECR values for Cr and Pb were above the range limit of 10⁻⁶ in all sample points. But the cancer risk was found to be very low.