bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pilot Study Testing the Efficacy of dCBT in Patients With Cancer Experiencing Sleep Problems
Authors: Chung Kyong-Mee , Suh Yung Jae , Chin Siyung , Seo Daesung , Yu Eun-Seung , Lee Hyun Jeong , Kim Jong-Heun , Kim Sang Wun , Koh Su-Jin 
Published: June 2022

ObjectiveThis pilot study aimed to evaluate the efficacy of a digital cognitive behavioral therapy (dCBT) in patients with cancer experiencing sleep problems.MethodsA total of 57 participants aged 25–65 years (6M/51F with a mean of 42.80 years and a standard deviation of 14.15 years) were randomly assigned to three groups—21 participants to a dCBT program (HARUToday Sleep), 20 participants to an app-based attentional control program (HARUCard Sleep), and 16 participants to a waitlist control group—and evaluated offline before and after the program completion. Of the 57 participants, there were a total of 45 study completers, 15 participants in each group. The dependent variables were sleep quality scores, measured by the Pittsburgh Sleep Quality Index (PSQI) and health-related quality of life scores, measured using the Short-Form 36 (SF-36), and attentional bias scores from a dot-probe computer task.ResultsFor both the intention-to-treat (N = 57) and study-completers analyses (N = 45, 15 for each group), a significant increase supported by a large effect size was found in the quality of sleep score of the HARUToday Sleep group compared to both the app-based attentional control and the waitlist control group. However, no significant changes were found in the quality of life and attentional bias scores.ConclusionOur results suggest that the HARUToday Sleep app has the potential to serve as an intervention module to enhance the sleep quality of patients with cancer experiencing sleep problems.
An Observational Study of Physicians' Workflow Interruptions in Outpatient Departments in China
Authors: Zhu Ximin , Hu Yinhuan , Wang Liuming , Li Dehe , Wu Xiaoyue , Xia Shixiao , Cheng Siyu 
Published: June 2022

BackgroundWorkflow interruptions are frequent in hospital outpatient clinics. Eventually, not only reducing the work efficiency and quality, but also further threatening patient safety. Over the last 10–15 years, research on workflow interruptions in inpatient care has increased, but there is a lack of research on the interruptions in outpatient clinics. The present study aimed to study the differences in physicians' workflow interruptions among outpatient departments in the tertiary hospital in China.MethodsIn a tertiary hospital, a standardized observational study of 32 doctors' workflow in outpatient department of four typical clinical specialties was conducted. The record of workflow interruptions was based on a self-made observation instrument after verifying its reliability and validity. Linear regression methods were used to assess outpatient characteristics as predictors of the number of interruptions. The Kruskal-Wallis test was used to analyze the difference about the duration of interruptions among specialties, and the Chi-Square Test was used to examine the sources of interruptions among different specialties, to determine whether interruption source is associated with specialty.ResultsThe number of patients was the significant independent predictor of the number of interruptions (p &lt; 0.001). In terms of work tasks being interrupted, the highest interruption rate occurred when physicians were asking health history: 19.95 interruptions per hour. The distribution of interruption sources among the four clinical specialties were statistically different (X2 = 16.988, p = 0.049).ConclusionThe findings indicate that physicians' workflow interruptions are connected with many contents in the work system. Further emphasis should be placed on the effective application of hospital management measures in an interrupted environment to promote a safe and efficiency outpatient care.
Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia
Authors: Kertész Gabriella , Kállay Krisztián , Kassa Csaba , Zombori Marianna , Bodó Imre , Kiss Csongor , Szegedi István , Kriván Gergely 
Published: June 2022

The first-line treatment of severe aplastic anemia is allogeneic hematopoietic stem cell transplantation with a matched sibling donor. However, co-morbidities of the identical donor can make donation difficult. We present a transplantation where in parallel with the patient’s conditioning treatment, the preparation of the donor with severe hemophilia A required a special management with perioperative factor VIII substitution. Donation was successful without complications, and 18 months after transplantation, the patient and his donor are well without any long-term sequelae. To our knowledge, this is the first reported succesfull transplantation with hemophilic child serving as a bone marrow donor. The procedure did not mean a significant risk to donor health, so donors with hemophilia should not be excluded from donation.
Elevated Cardiac Troponin to Detect Acute Cellular Rejection After Cardiac Transplantation: A Systematic Review and Meta-Analysis
Authors: Liu Zhengyang , Perry Luke A. , Penny-Dimri Jahan C. , Handscombe Michael , Overmars Isabella , Plummer Mark , Segal Reny , Smith Julian A. 
Published: June 2022

Cardiac troponin is well known as a highly specific marker of cardiomyocyte damage, and has significant diagnostic accuracy in many cardiac conditions. However, the value of elevated recipient troponin in diagnosing adverse outcomes in heart transplant recipients is uncertain. We searched MEDLINE (Ovid), Embase (Ovid), and the Cochrane Library from inception until December 2020. We generated summary sensitivity, specificity, and Bayesian areas under the curve (BAUC) using bivariate Bayesian modelling, and standardised mean differences (SMDs) to quantify the diagnostic relationship of recipient troponin and adverse outcomes following cardiac transplant. We included 27 studies with 1,684 cardiac transplant recipients. Patients with acute rejection had a statistically significant late elevation in standardised troponin measurements taken at least 1 month postoperatively (SMD 0.98, 95% CI 0.33–1.64). However, pooled diagnostic accuracy was poor (sensitivity 0.414, 95% CrI 0.174–0.696; specificity 0.785, 95% CrI 0.567–0.912; BAUC 0.607, 95% CrI 0.469–0.723). In summary, late troponin elevation in heart transplant recipients is associated with acute cellular rejection in adults, but its stand-alone diagnostic accuracy is poor. Further research is needed to assess its performance in predictive modelling of adverse outcomes following cardiac transplant.Systematic Review Registration: identifier CRD42021227861
Analisis Kadar Vitamin C Wedang Jeruk Nipis (Citrus Aurantifolia) Berdasarkan Variasi Suhu Menggunakan Metode Spektrofotometri Uv – Vis
Authors: Yulianto Susilo , Jamilatun Makhabbah , Jamilatun Makhabbah , Pangesti Feby Ari , Pangesti Feby Ari 
Published: June 2022

Vitamin C merupakan salah satu vitamin yang mudah larut dalam air.dan mudah mengalami kerusakan oleh reaksi oksidasi. Suhu sangat berpengaruh terhadap penurunan kadar vitamin C. Salah satu buah yang mengandung vitamin C yaitu buah jeruk nipis. Jeruk Nipis dapat dibuat beberapa minuman salah satunya wedang jeruk nipis dengan berbagai variasi cara pembuatan yaitu dibuat dengan suhu dingin, ruang, hangat, dan panas. Pada umumnya masyarakat tidak menyadari bahwa minuman yang mengandung vitamin C membutuhkan suhu yang tepat agar kandungan kadar vitamin C tetap utuh saat dikonsumsi Tujuannya yaitu untuk mengentahui kadar vitamin C dalam wedang jeruk nipis dan menganalisis perbedaan kadar vitamin C dalam wedang Jeuk nipis. Wedang jeruk nipis dibuat 4 formula variasi suhu yaitu suhu dingin, ruang, hangat dan panas. Jenis penelitian ini adalah penelitian kuantitatif. Parameter yang diamati dalam penelitian ini adalah kadar vitamin C. Kadar vitamin C dianalisis menggunakan metode Spektrofotometri uv-vis pada Panjang gelombang 262 nm. Kadar vitamin C tertinggi pada suhu dingin sebesar 0,07096%, suhu ruang yaitu sebesar 0,06328%, suhu hangat yaitu sebesar 0,05116%, dan air panas yaitu sebesar 0,02740%. Data yang diperoleh dianalisis dengan uji anova satu arah. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan terhadap kadar vitamin C pada wedang jeruk nipis dalam variasi suhu.
Predictors of BMI and WHR among Malaysians of Different Cultural Background
Authors: Botabara-Yap Mary Mary 
Published: June 2022

The epidemic of overweight and obesity is encroaching in the world today, irrespective of economic and social status and regions. It is now seen as a public health threat and one that must be taken seriously in all aspects of public health interventions. This study investigates the predictors of overweight and obesity, as measured by body mass index (BMI) and waist-to-hip ratio (WHR) among Malaysians. A questionnaire survey was conducted among 459 samples from those who attended a health screening drive, conducted in three major regions in Peninsular Malaysia. Data were analyzed using descriptive statistics such as mean and standard deviation as well as multiple regression, with p <0.05 considered significant. Results showed that 56% of the respondents were overweight, the prevalence was highest among Indians (24.6%, 95% CI=20.3, 29.3), followed by Malays (23.2%, 95% CI=21.6, 24.8%) while the lowest prevalence was among the Chinese respondents (8.2%, 95% CI=6.2, 10.6). Smoking (p value of .000) and physical activity (p value of .023) were predictors for BMI while smoking (p value of .000) was a predictor of WHR. Findings showed that the problem of overweight and obesity in Malaysia is real and smoking and physical activity play a strong role and need to be considered in any public health interventions.
Development of Vegetable Marmalade Using Okra’s (Abelmoschus esculentus) Mucilage
Authors: Fronda Blessie Xuxa , Gamboa Mariannie , Zabala John David , Oasan Ruchel 
Published: June 2022

Okra, the popular name of the “lady finger” plant, has always been neglected by consumers due to its sliminess. Thus, the study utilized the okra mucilage as a substitute for pectin in producing marmalade. A systematic cooking of ingredients (okra mucilage, pandan, lemon extract, and lemon rind) using the standardized recipe was done in order to come up with a successful product. A serving (15g) of the vegetable marmalade was found to have a nutrient content of 195 kcal, 2.3g protein, 0.5g fat, 45.4 carbohydrates, 203mg calcium, 68mg phosphorus, 1.3mg iron, 29µg vitamin A, 0.1mg thiamin, 0.13mg riboflavin, 1.4mg niacin, and 31 mg vitamin C. The finished product was evaluated by 30 people. Results showed that almost all of the evaluators answered liked the product extremely and very much (70.00%, 79.99%, 60.00%, 53. 34% and 70.00%, for color, taste, texture, aroma, and appearance, respectively). The vegetable marmalade is packed in a sterile jar and can be consumed within two weeks when stored at a room temperature. The raw cost of a serving is PhP5.20, while the selling price per jar is PhP117.12, which is cheaper compared to other marmalade products. Therefore, it is possible to produce marmalade utilizing okra’s mucilage.
Adjustment of First and Second Year Nursing Students, Mission Faculty of Nursing, Asia-Pacific International University
Authors: Sriratanaprapat Jarurat , Theurnsiri Prayadsri 
Published: June 2022

On average, nursing students resigned 6.9% in the past 5 years. No study conducted in non-profit, religious based university. This research aimed to study the adjustment level of nursing students and their adjustment differentiated by age and CGPA. Havighurst Theory as fundamental of adjustment was discussed. One hundred sixty-one purposive samples were selected. The instrument was adopted with acceptable validity and reliability. One sample t-test was performed and result showed mean total adjustment score (3.89 ± 0.41) which is higher than set norm adjustment score, a statistically significant difference of 0.89 (95% CI, 0.83-0.96), t(160) = 27.74, p = .000. Independent t-test was done and result revealed no significant difference in the adjustment score for 18-20 years old (M=3.89, SD=.42) and 21-23 years old (M=3.93, SD=.40); t (151) =-.42, p = 0.68. Lastly, one-way ANOVA was executed and found no significant effect of CGPA on adjustment score at the p < .05 level [F (4, 148) = 1.34, p = 0.26]. Overall, students’ adjustment is at high level and their age including CGPA has no effect on the adjustment. Others can learn how they adjust and other factors like income or passion in nursing should be explored.
The Dengvaxia Issue: Its Influence on Mothers’ Perception on Child Vaccination
Authors: Lun Zen Sian , Dorado Jan Lenard , Qian Wang Xue , Mergal Beryl Ben C. , Hernandez Narcar 
Published: June 2022

Dengue has been endemic in several countries worldwide. It is reported that millions are infected with the disease yearly, causing thousands of deaths. The Dengvaxia issue occurred when Sanofi Pasteur announced that the vaccine, which has been administered to grade-schoolers in the Philippines, can only be effective for those who have been previously infected with dengue. It has also been reported that the immunization program of the Philippines has been experiencing a decrease in the immunization rate. The study aimed to look into the influence of the Dengvaxia issue on mothers’ perceptions on child vaccination. This study employed a qualitative phenomenological research design. To recruit for participants, a purposive sampling method and snowball sampling methods were utilized to select 11 participants. A validated semi-structured questionnaire was used for the interview. Participants included mothers of children ages 0-24 months who have knowledge of the Dengvaxia issue. The data gathered were then analyzed using standardized methods. The findings of the study revealed that on the Dengvaxia issue, the themes were fear, empathy, and anger. On the mother’s perception towards vaccination, the themes were protection and giving up authority. Also, in terms of the influence of Dengvaxia Issue on child vaccination, identified themes were vaccine confidence and vaccine hesitancy. Furthermore, the study also revealed that nine out of the 11 mothers are still in favor of their children being vaccinated. It was therefore recommended that nurses must do continuous health education about the positive effects of immunizations in the community.
Correlates and Demographic Differences on Nurses’ Awareness and Preparedness on Palliative Care to End-of-Life Care Practices: Basis for an Intervention Program
Authors: Yabut April Sodusta , Guerra-Polancos Jacqueline 
Published: June 2022

Studies have shown that the Philippines has less emphasis on supplying quality palliative care and that end-of-life care is inadequate and limited. This study explored the relationship and demographic differences in awareness, and preparedness on palliative care and practices towards end-of-life care among hospital nurses. The descriptive-correlation design was utilized in this study. Respondents were 381 hospital nurses from 17 different hospitals from eight different regions. A conceptualized self-constructed questionnaire from literature was developed and used in gathering the data. Results of the analysis showed that nurses have very high (M=3.50, SD=0.33) awareness but only have a high (M=3.47, SD=0.34) level of preparedness in palliative care. Whereas, end-of-life care practices as to psycho-spiritual (M=3.92, SD=0.50), socio-cultural (M=4.11, SD=0.56), physical (M=4.44, SD=4.44), and coordination (M=4.35, SD=0.50) are all often practiced. Correlation analysis revealed that both awareness and preparedness on palliative are positively, and significantly correlated with their end-of-life care practices (p=0.00; p=0.00). There were no significant differences found in end-of-life care practices considering age, gender, marital status, years of clinical experience, and unit of assignment of the nurses. Moreover, only preparedness came out as significant predictor of all the dimensions of practices (R2=0.18, p=0.00; R2=0.16, p=0.00; R2=0.12, p=0.00; R2=0.13, p=0.00) It is recommended that a further study that will consider other factors in examining the relationship and differences between the variables be conducted.
Four Ways to Ease Dysmenorrhea: A Comparative Study
Authors: Soputri Nilawati , Wadu Sabatini Kitnasari Kana , Nathania Ayu 
Published: June 2022

Dysmenorrhea is a pain that occurs before or during menstruation. The pain is generally felt in the lower abdomen and can spread to the hips and thighs with intensity ranging from mild to uncontrolled pain. Often women who experience dysmenorrhea cannot even perform daily activities. This study aims to compare four natural ways to ease dysmenorrhea. Sixty students at a private university in Indonesia who are constantly experiencing dysmenorrhea every month at the time of their menstruation were voluntary involved in this study. They were divided into four groups: 15 students did dysmenorrhea exercise, 15 students did jogging, 15 students underwent massage therapy, and 15 students underwent music therapy. The 60 research samples did not take pain killers or use other methods to relieve pain. The instrument used to measure pain before and after intervention is a numerical rating scale with a scale of 0 for painless to 10 for uncontrolled pain. The results showed that the average value of pain before dysmenorrhea exercise is 4.47 and after exercise is 1.47 (z = -3.69, p = 0.00 < α = 0.005). The average value of pain before the jogging is 4.47 and after jogging is 1.93 (z = -3.51, p = 0.00 < α = 0.005). For the massage group, the average of pain before treatment is 4.67 and after therapy to 1.2 (z = -3.22, p = 0.00 < α = 0.005). Average pain scale for music therapy before intervention is 4.13 and after therapy to 2.67 (z = -3.04, p = 0.00 < α = 0.005). There is a statistically significant difference between the study groups by using one-way ANOVA (F = 2.289, p = 0.43). A Tukey post Hoc test revealed that only the massage group (3.47 ) is statistically more effective in relieving dysmenorrhea than jogging (2.53 . Multiple comparisons between the other groups don’t show any significant difference to relieve dysmenorrhea.
Body Weight and Blood Pressure of Young Adult Women in Universitas Advent Indonesia
Authors: Malinti Evelin , Lola Firdawati 
Published: June 2022

The number of people in the world with high blood pressure is on the rise, and the incidence rates among young women are increasing. One of the risk factors of elevated blood pressure is obesity. This study aimed to determine the differences in blood pressure between young adult women with normal body weight and overweight at the Universitas Advent Indonesia. The research design used in this study is descriptive analysis. A total of 224 respondents participated in the study that consisted of 112 respondents with the category of normal weight and 112 respondents with the category of overweight. The blood pressures of all respondents are measured in the morning before breakfast. The results showed that the group of participants with normal weight and the group of participants with overweight category had normal range systolic and diastolic blood pressure. The results on both systolic and diastolic blood pressure between the two groups showed significant differences (p <.05). This study proves that body weight affects blood pressure in young age women.
Pelatihan Pembuatan Website Sederhana Dalam Pemasaran Produk dengan Aplikasi Joomla Bagi UMKM LPM Rempoa
Authors: Aulianita Rizki , Nisa Khoirun , Rakhmah Syifa Nur , Yunita Norma 
Published: June 2022

Usaha Micro Kecil Menengah (UMKM) merupakan tonggak pergerakan ekonomi masayarakat saat ini. Namun tidak sedikit juga UMKM yang gulung tikar akibat pandemic Covid-19. UMKM pada Lembaga Pemberdayaan Masyarakat (LPM) Rempoa merupakan Lembaga yang sudah berdiri sejak lama namun belum adanya penerapan teknologi secara optimal dalam pemasaran produk barang dagangan. Selama ini pemesaran atau distribusi barang dagang dilakukan secara offline menggunakan sarana seadanya. Sehingga menimbulkan permasalahan seperti kurang berkembangnya UMKM yang tidak dapat berekspansi maupun berinovasi khususnys dalam penerapan teknologi, pangsa pasar sempit dan modal yang terbatas. Untuk itulah penulis mengangkat permasalahan ini dengan melakukan pelatihan penggunaan website sederhana menggunakan aplikasi Joomla bagi UMKM LPM Rempoa. Data yang diperoleh berdasarkan kuisioner. Hasilnya adalah 80% para UMKM menjadi lebih melek teknologi dan berusaha untuk diterapkan di pemasarannya masing-masing
Toward RNA Life on Early Earth: From Atmospheric HCN to Biomolecule Production in Warm Little Ponds
Authors: Pearce Ben K. D. , Molaverdikhani Karan , Pudritz Ralph E. , Henning Thomas , Cerrillo Kaitlin E. 
Published: June 2022

Abstract
The origin of life on Earth involves the early appearance of an information-containing molecule such as RNA. The basic building blocks of RNA could have been delivered by carbon-rich meteorites or produced in situ by processes beginning with the synthesis of hydrogen cyanide (HCN) in the early Earth’s atmosphere. Here, we construct a robust physical and nonequilibrium chemical model of the early Earth’s atmosphere. The atmosphere is supplied with hydrogen from impact degassing of meteorites, water evaporated from the oceans, carbon dioxide from volcanoes, and methane from undersea hydrothermal vents, and in it lightning and external UV-driven chemistry produce HCN. This allows us to calculate the rain-out of HCN into warm little ponds (WLPs). We then use a comprehensive numerical model of sources and sinks to compute the resulting abundances of nucleobases, ribose, and nucleotide precursors such as 2-aminooxazole resulting from aqueous and UV-driven chemistry within them. We find that 4.4 billion years ago the limit of adenine concentrations in ponds for habitable surfaces is 0.05 μM in the absence of seepage. Meteorite delivery of adenine to WLPs can provide boosts in concentration by 2–3 orders of magnitude, but these boosts deplete within months by UV photodissociation, seepage, and hydrolysis. The early evolution of the atmosphere is dominated by the decrease in hydrogen due to falling impact rates and atmospheric escape, and the rise of oxygenated species such as OH from H2O photolysis. The source of HCN is predominantly from UV radiation rather than lightning. Our work points to an early origin of RNA on Earth within ∼200 Myr of the Moon-forming impact.