bluuebunny/crossref_metadata_2025_split huggingface dataset:
Passively immobilized cyanobacteria Nostoc species BB 92.2 in a moving bed photobioreactor (MBPBR): Design, cultivation, and characterization
Authors: Walther Jakob , Erdmann Niklas , Stoffel Michael , Wastian Katharina , Schwarz Anna , Strieth Dorina , Muffler Kai , Ulber Roland 
Published: February 2022

AbstractThe cyanobacterium Nostoc sp. BB 92.3. had shown antibacterial activity. A cultivation as biofilm, a self‐forming matrix of cells and extracellular polymeric substances, increased the antibacterial effect. A new photobioreactor system was developed that allows a surface‐associated cultivation of Nostoc sp. as biofilm. High‐density polyethylene carriers operated as a moving bed were selected as surface for biomass immobilization. This system, well established in heterotrophic wastewater treatment, was for the first time used for phototrophic biofilms. The aim was a cultivation on a large scale without inhibiting growth while maximizing immobilization. Cultivation in a small photobioreactor (1.5 L) with different volumetric filling degrees of carriers (13.4%–53.8%) in a batch process achieved immobilization rates of 70%–85% and growth was similar to a no‐carrier‐control. In a larger photobioreactor (65 L) essentially all of the biomass was immobilized on the carriers and the space‐time yield of biomass (0.018 gcell dry weight L−1 day−​​​​​​​1) was competitive compared to phototrophic biofilm cultivations from literature. The use of carriers increased the gas exchange in the reactor by a factor of 2.5–3 but doubled the mixing time. Enriched gassing with carbon dioxide resulted in a short‐term increase in growth rate, but unexpectedly it also adversely changed the growth morphology.
A Quality by Design and green LC technique for the determination of mast cell stabilizer and histamine receptor antagonist (Olopatadine HCl) in multiple formulations
Authors: Kowtharapu Leela Prasad , Katari Naresh Kumar , Ch. Surekha , Sandoval Christian A. , Muchakayala Siva Krishna , Konduru Naresh 
Published: February 2022

AbstractMast cell stabilizer and histamine receptor antagonist olopatadine hydrochloride (OPT) assay method predicated on LC have been established for the analysis in multiple formulations. The current method dealt with ophthalmic solution, nasal spray, and tablet formulation products. The isocratic chromatography method was optimized and validated with a Boston green C8 column (150 × 4.6 mm, 5 μm i.d.). Sodium dihydrogen phosphate buffer (pH 3.5) with acetonitrile in the ratio of 75:25 (v/v) was used as a mobile phase at a flow rate of 1.0 mL min−1 and at the column temperature of 30°C, and the detection was done at 299 nm. The method was validated as per International Council for Harmonisation (ICH) guidelines and United States Pharmacopoeia (USP). The accuracy results ranged from 99.9 to 100.7%, % relative standard deviation (RSD) from the precision was 0.5, and correlation coefficient from the linearity experiment was > 0.999. Solution stability was established for 24 h at room temperature and refrigerator conditions, and it was found that the solutions were stable. Using quality by design‐based experiment designs, critical quality attributes were studied and it was found that the method was robust. In all the forced degradation studies peak purity was passed, and no interference was found at the retention time of the active component. The method validation data demonstrated that the developed method is linear, precise, accurate, specific, robust, and stable for the determination of OPT from multiple formulations. Analytical eco‐scale tool, Green Analytical Procedure Index (GAPI) tool, and the National Environmental Method Index (NEMI) were used to evaluate the greenness of the method, and the analytical eco‐score of 77 for the presented method was found to be excellent.
Circular economy business models as resilient complex adaptive systems
Authors: De Angelis Roberta 
Published: February 2022

AbstractBroad consensus seems to have emerged on the circular economy as a plausible and desirable solution to build prosperity while respecting ecological boundaries. However, its implementation in industry is slow paced. Whilst the systemic nature of the innovation required and barriers to implementation in complex sustainability transitions partially explain why this is the case, reflecting on the contribution of the growing scholarly literature on circular business models to orient management practice is also relevant. In fact, despite the existence of a fairly voluminous scholarly literature on the subject, practitioners are either uncertain or struggling about how to implement circular economy strategies and models. Using an integrative research approach to theory building and drawing on systems theory, this article proposes a resilient complex adaptive system view of circular business models. The resulting framework is a stepping‐stone to overcoming conceptual ambiguities and construct fallacies in the way circular business models are typified.
Biomarkers expression among paired serous ovarian cancer primary lesions and their peritoneal cavity metastases in treatment‐naïve patients: A single‐center study
Authors: Nikas Ilias P. , Lee Cheol , Song Min Ji , Kim Bohyun , Ryu Han Suk 
Published: February 2022

AbstractBackgroundHigh‐grade serous ovarian carcinoma (HGSOC), the most common histologic subtype of ovarian epithelial cancer, is associated with treatment resistance, enhanced recurrence rates, and poor prognosis. HGSOCs often metastasize to the peritoneal cavity, while fluid cytology examination could identify such metastases. This retrospective study aimed to identify potential biomarker discrepancies between paired HGSOC primary tissues and metastatic peritoneal fluid cytology samples, processed as cell blocks (CBs).MethodsTwenty‐four pairs of formalin‐fixed, paraffin‐embedded primary tissues and metastatic CBs from an equal number of treatment‐naïve patients were used, and immunohistochemistry (IHC) for epidermal growth factor receptor (EGFR), human epidermal growth factor receptor, programmed cell death‐1 ligand 1 (PD‐L1), and CD147 was applied.Results13/24 pairs showed discordant EGFR IHC results; in all these 13 patients, EGFR was positive (≥1+ membranous staining intensity found in at least 10% of the cancer cells) in the peritoneal, yet negative in the primary tissue samples. Notably, EGFR IHC was positive in 15/24 of the metastatic, whereas in just 2/24 of the primary HGSOC samples (p < 0.001). Although most PD‐L1 results were concordant, 5/24 and 6/24 pairs exhibited discordant results when stained with the E1L3N and 22C3 clones, respectively. Lastly, CD147 overexpression was found more often in the metastatic rather than the matched primary HGSOCs stained with CD147, though the difference was not significant.ConclusionsCytology from effusions could be considered for biomarker testing when present, even when tissue from the primary cancer is also available and adequately cellular, as it could provide additional information of potential clinical significance.
Selective Alkyne Semi‐Hydrogenation by PdCu Nanoparticles Immobilized on Stereocomplexed Poly(lactic acid)
Authors: Oberhauser Werner , Frediani Marco , Mohammadi Dehcheshmeh Iman , Evangelisti Claudio , Poggini Lorenzo , Capozzoli Laura , Najafi Moghadam Peyman 
Published: February 2022

AbstractPolymer‐supported PdCu alloy nanoparticles with a palladium to copper atom ratio of 1 have been synthesized upon: (i) Coordination of palladium/copper acetate to 2,2’‐bipyridine‐end functionalized poly(lactic acid) (PLA); (ii) Stereocomplexation of PLA‐based macrocomplexes of opposite stereochemistry, and (iii) metal reduction with hydrogen. The obtained supported PdCu nanoparticles were successfully applied in the semi‐hydrogenation of industrially important alkynols, such as 3‐hexyn‐1‐ol and 2‐butyne‐1,4‐diol leading to the corresponding cis‐alkenol in high selectivity (98 %) under mild reaction conditions (i. e. ethanol, T (25 °C), p(H2)=3 bar) in the absence of any further additive. From a comparison of the catalytic performance of supported PdCu nanoparticles with those of Pd and Cu, located in the same chemical environment, emerged a clear alloy effect (i. e. high chemoselectivity for the alkene at high alkyne conversion). Recycling experiments conducted with the PdCu‐based catalyst proved the stability of the catalyst with time, even by its recovering in air atmosphere.
Impact of Intermolecular Non‐Covalent Interactions in a CuI8PdII1 Discrete Assembly: Conformers’ Geometries and Stimuli‐Sensitive Luminescence Properties
Authors: Moutier Florent , Schiller Jana , Lecourt Constance , Khalil Ali Moustafa , Delmas Vincent , Calvez Guillaume , Costuas Karine , Lescop Christophe 
Published: February 2022

AbstractA new highly solid‐state luminescent phase of a previously reported weakly luminescent CuI8PdII1 dicationic assembly is reported revealing the high geometrical versatility of this moiety that importantly alters its luminescent properties. This very minor new species Bc is based on a different conformer scaffold than the one encountered in the previously reported Bo form and, essentially differs from Bo by displaying shorter CuI‐CuI intermetallic distances. DFT calculations allow concluding that the predominance in the solid‐state of the weakly luminescent and less stable Bo phase is due to the extra stability induced by a larger number of intermolecular non‐covalent π‐CH interactions in its crystalline packing and not by the intrinsic stability of the CuI8PdII1 dicationic moiety. Calculations also revealed that a more stable conformation Bcalc is expected in vacuum, which bears a different distribution of CuI‐CuI intermetallic distances than the dications in Bo and Bc phases. Taking into account that the geometrical alterations are associated to drastic changes of luminescence properties, this confer to the CuI8PdII1 assembly high potentiality as stimuli‐sensitive luminescent materials. Indeed, by applying mechanical or thermal stress to samples of Bo phase, new phases Bg and Bm, respectively, were obtained. Alterations of the solid‐state photophysical properties of these new species compared to those recorded for Bo are reported together with a combined experimental and computed study of the structures/properties relationships observed in these phases.
A Fully Conjugated Porphyrin‐[36]Octaphyrin‐Porphyrin Hybrid Tape Exhibiting Möbius Aromaticity
Authors: Nakai Akito , Tanaka Takayuki , Osuka Atsuhiro 
Published: February 2022

AbstractDirectly meso‐meso linked porphyrin‐tetrabromo[36]octaphyrin‐porphyrin hybrid trimer 10 was successfully synthesized via acid‐catalyzed condensation reaction and subsequent oxidation. ZnII‐metalation of 10 induced transannular meso‐meso bond formation to give Möbius aromatic bis‐ZnII octaphyrin 11, which was oxidized by DDQ/Sc(OTf)3 to provide fully conjugated porphyrin‐[36]octaphyrin‐porphyrin hybrid tape 12 as the first example of porphyrin tape exhibiting Möbius aromaticity. Hybrid tape 12 displays significantly red‐shifted absorption and small electrochemical HOMO‐LUMO gap, indicating the effective conjugation through the whole chromophores.
Controlling Tautomerization in Pyridine‐Fused Phosphorus‐Nitrogen Heterocycles
Authors: McNeill J. Nolan , Karas Lucas J. , Bard Jeremy P. , Fabrizio Kevin , Zakharov Lev N. , MacMillan Samantha N. , Brozek Carl K. , Wu Judy I. , Johnson Darren W. , Haley Michael M. 
Published: February 2022

AbstractInclusion of a second nitrogen atom in the aromatic core of phosphorus‐nitrogen (PN) heterocycles results in unexpected tautomerization to a nonaromatic form. This tautomerization, initially observed in the solid state through X‐ray crystallography, is also explained by computational analysis. We prepared an electron deficient analogue (2 e) with a fluorine on the pyridine ring and showed that the weakly basic pyridine resisted tautomerization, providing key insights to why the transformation occurs. To study the difference in solution vs. solid‐state heterocycles, alkylated analogues that lock in the quinoidal tautomer were synthesized and their different 1H NMR and UV/Vis spectra studied. Ultimately, we determined that all heterocycles are the aromatic tautomer in solution and all but 2 e switch to the quinoidal tautomer in the solid state. Better understanding of this transformation and under what circumstances it occurs suggest future use in a switchable on/off hydrogen‐bond‐directed receptor that can be tuned for complementary hydrogen bonding.
The broken record: How the music industry is making sense of uncertainty and change
Authors: Green Todd , Sinclair Gary 
Published: February 2022

AbstractAs the recording music industry entered the digital era, significant turmoil emerged due to piracy and illegal downloading, and royalty payments to artists via streaming platforms. To date, the previous research examining the industry shift focused on consumer‐based decisions such as whether to download music illegally, and, more recently, experiences with streaming services. Using sensemaking as our lens, we examine changes and challenges through in‐depth interviews with music industry practitioners. The participants have been directly impacted by the digital shift in general and by specific issues such as piracy and poor compensation from streaming platforms. We develop a typology of industry members based on their development of sensemaking capabilities as they navigate the ever‐changing industry and the resulting influence on market practices.
Data characteristics aware prediction model for power consumption of data center servers
Authors: Shen Ziyu , Zhou Qing , Zhang Xusheng , Xia Bin , Liu Zheng , Li Yun 
Published: February 2022

SummaryDue to the rapid increase in the number and scale of data centers, the information and communication technology (ICT) equipment in data centers consumes an enormous amount of power. A power prediction model is therefore essential for decision‐making optimization and power management of ICT equipment. However, it is difficult to predict the power consumption of data centers accurately due to the complex power patterns and nonlinear interdependencies among components. Existing methods either rely on standard formulas, or simply treat it as time series, both leading to poor power prediction accuracy. To overcome those limitations, in this article, we present a systematic power prediction framework called characteristic aware attention‐augmented deep learning‐based prediction method. In particular, we first analyze the different power consumption series to illustrate their different temporal characteristics. Second, we perform different data processing for the corresponding characteristics of power series samples. Third, we propose an accurate and efficient neural network model to predict future power consumption with the pretreated data. The experimental results show that the proposed model is able to achieve superior prediction accuracy.
Combining Open‐Shell Verdazyl Environment and Co(II) Spin‐Crossover: Spinmerism in Cobalt Oxoverdazyl Compound
Authors: Roseiro Pablo , Ben Amor Nadia , Robert Vincent 
Published: February 2022

AbstractThe spin states of a Co(II) oxoverdazyl compound are investigated by means of wavefunction‐based calculations. Within a ca. 233 K energy window, the ground state and excited states display a structure‐sensitive admixture of low‐spin SM=1/2 in a dominant high‐spin SM=3/2 Co(II) ion as indicated by the localized molecular orbitals. The puzzling spin zoology that results from the coupling between open‐shell radical ligands and a spin‐crossover metal ion gives rise to this unusual scenario, which extends the views in molecular magnetism. In agreement with experimental observation, the low‐energy spectroscopy is very sensitive to deformations of the coordination sphere, and a growing admixture of Co(II) low‐spin is evidenced from the calculations. In analogy with mesomerism that accounts for charge delocalization, entanglement combines different local spin states to generate a given total spin multiplicity, a spinmerism phenomenon.
Diabetic ketoacidosis amongst patients with COVID‐19: A retrospective chart review of 220 patients in Pakistan
Authors: Muhammad Asim , Hakim Muhammad , Afaq Saima , Khattak Farhad Ali , Shakireen Najmush , Jawad Muhammad , Saeed Rabia , Haq Zia Ul 
Published: February 2022

AbstractObjectivesTo determine the frequency of diabetes mellitus and diabetic ketoacidosis and associated factors in COVID‐19‐positive patients.BackgroundHigh mortality amongst SARS‐Cov2 patients may be attributed to diabetes and diabetic ketoacidosis.MethodsA total of 220 COVID‐19 positive patients, hospitalized in North West General Hospital & Research Center, Peshawar, KP, Pakistan, from April to September 2020, were analysed using STATA 14. Patients with positive PCR were labelled as COVID‐19 positive and were included in the study. Patients with a clinical picture of COVID‐19 and negative PCR were excluded from the study. Those having ketonemia >0.6 and random blood glucose level >250mg/dl, while HCO3 (bicarbonate) ≤18, were labelled as diabetic ketoacidosis. The statistical significance level was set at p < .05.ResultsA total of 220 COVID‐19 patients were admitted; 166 (75.4%) were male and 54 (24.5%) were female. The mean age in years of the patients was 55.95 (SD13.9). About 57.7% of patients had diabetes mellitus, and 15 (6.8%) patients developed diabetic ketoacidosis. Amongst those with DKA, 5 patients died during hospital admission. The use of steroids was significantly higher (p < .001) in the DKA group compared with non‐DKA patients. Hypertension (103,46.8%) and fever (170,77.3%) were the most reported comorbidity and symptom respectively.ConclusionThe proportion of diabetes mellitus is high in patients with COVID‐19. Diabetic ketoacidosis is a frequent complication in this group associated with in‐hospital mortality. Steroid administration for COVID‐19 should be balanced with strict glycemic control to prevent diabetic ketoacidosis and increase hospital survival.
Eating disorder onset during childhood is associated with higher trauma dose, provisional PTSD, and severity of illness in residential treatment
Authors: Brewerton Timothy D. , Gavidia Ismael , Suro Giulia , Perlman Molly M. 
Published: February 2022

AbstractObjectiveAge of eating disorder (ED) onset has been of significant interest to both researchers and clinicians. The identification of factors associated with early or child onset has important prevention and treatment implications. The presence of prior trauma, resultant posttraumatic stress disorder (PTSD), ED severity, and comorbid psychopathology are of particular relevance to age of ED onset, but data are limited.MethodsAdults (≥18 years, 93% female, total n = 1283) admitted to residential ED treatment self‐reported age of ED onset. Patients were divided into child onset (ages 5–10 years), adolescent onset (11–17 years), and adult onset (≥18 years) groups and compared on a number of clinical features and assessment measures.ResultsThe child onset group had significantly higher rates and doses of traumatic life events; higher current PTSD prevalence; higher BMIs, higher severity of ED, depression and state‐trait anxiety symptoms; worse quality of life; and more prior inpatient and residential admissions for ED treatment, in comparison to both the adolescent and adult onset groups. Similarly, the adolescent onset group had significantly higher rates than the adult onset group.ConclusionsThese results have important implications for prevention, treatment and long‐term follow‐up and highlight the need for early trauma‐focussed treatment of ED patients.
Comparison of Exposure Techniques and Vitality Assessment of Mosses in Active Biomonitoring for Their Suitability in Assessing Heavy Metal Pollution in Atmospheric Aerosol
Authors: Świsłowski Paweł , Nowak Arkadiusz , Rajfur Małgorzata 
Published: February 2022

Abstract
The most widespread and used technique is the moss-bag method in active biomonitoring of air pollution using mosses. In the literature, we can find various studies on the standardization of this method, including attempts to standardize treatments and preparation procedures for their universal application. Few works comprehensively focus on other methods or compare other techniques used in active biomonitoring with mosses, especially including measurements of their vital parameters. Our experiment aimed to assess air pollution by selected heavy metals (Cu, Zn, Cd, Pb, Mn, Fe, and Hg) using three moss species (Pleurozium schreberi, Sphagnum fallax, and Dicranum polysetum) during a 12-week exposure in an urban area. Mosses were exposed simultaneously using four techniques: moss bag in three variants (exposed to air for total deposition of heavy metals, exposed to air for only dry deposition, and sheltered from the wind) and transplants in boxes. Increases in heavy metal concentrations in mosses were determined using the relative accumulation factor (RAF). The actual quantum yield of photosystem II photochemical was also analyzed as the main vitality parameter. The results indicate that all moss species during the changing environmental conditions survived and retained their vitality, although it decreased by &gt;50% during the exposure. The best biomonitor was the moss P. schreberi, whose RAF increments were the highest throughout the study period for the majority of elements. The moss-bag technique had a statistically significant effect (almost 40%) on the concentration value of a given metal for a certain species, and thus it is the most recommended technique that can be applied in air quality monitoring in urban areas. Environ Toxicol Chem 2022;41:1429–1438. © 2022 SETAC
What are the characteristics of the cases we use to teach and learn evaluation?
Authors: Kallemeyn Leanne M. , Titiml Eleanor N. , Galib Linda , Castelin Kim , Montrosse‐Moorhead Bianca , Ensminger David C. , Linfield Kenneth J. 
Published: February 2022

AbstractCase‐centered teaching and learning is important for illustrating evaluation approaches, practicing professional problem‐solving and ethical decision‐making, and teaching professional skills and competencies. In this study we provide findings on a content analysis of 148 written cases used to teach evaluation and a critical analysis of five purposively selected cases. The findings demonstrate that evaluators have written many cases to teach the situational nature of evaluation practice. Most of the cases are simulations of practice, which include how the case actors’ think, decide, and act in an evaluation context. The study findings point to several areas for strengthening case‐centered teaching in evaluation, including providing clear learning objectives, developing supporting resources for instructors, aligning cases with professional competencies and/or core concepts in the field, developing cases to promote active and problem‐based learning, ensuring cases represent equity‐informed practices, and broadening the representation of diverse people and contexts.
How do we teach and learn with cases?
Authors: Montrosse‐Moorhead Bianca , Ensminger David C , Roseveare Christine 
Published: February 2022

AbstractIn this article, we review the literature on learning and teaching with cases drawing from several applied professions (e.g., education, business, medicine). First, we summarize the learning philosophies and concepts that ground case‐centered teaching and learning. This section touches on views of professional practice, important and relevant theories and concepts, and the value of decomposition of professional practice. Then, we use the idea of decomposition of professional practice to illuminate for readers how the learning philosophies and concepts that ground case‐centered teaching might show up in evaluation classrooms. This discussion necessarily focuses on instructional design, types of cases, issues to consider in selecting cases, developing meaningful questions, and cultivating the type of learning environment case‐centered teaching and learning demands. Implications for evaluation educators and research on evaluation are noted.