bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytotoxicity, Molecular Docking, ADMET and DFT Analysis of Alkaloids from the Roots and Fruits ofVepris dainelli
Authors: Anza Mathewos , Endale Milkyas , Cardona Luz , Cortes Diego , Cabedo Nuria , Eswaramoorthy Rajalakshmanan , Abarca Belen , Domingo-Ortí Inés , Palomino-Schätzlein Martina 
Published: January 2022

Background:Vepris dainelli (Rutaceae) is an endemic medicinal plant of Ethiopia, traditionally used for the treatment of abdominal cramps, intestinal worms, skin diseases, and tooth pain.Methods:Roots and fruit extracts were subjected to silica gel column chromatographic separation to afford five alkaloids, reported for the first time from the species. The cytotoxic effects of alkaloids (2-4) were evaluated in vitro against the estrogen-responsive MCF-7 and estrogen-unresponsive MDA-MB-231 human breast cancer cell lines by MTS assay.Result:The results revealed that alkaloids (2-4) induced a significant reduction in cell growth of both breast cancer cell lines in a dose-dependent manner. Evodiamine (4) showed the highest potency against the aggressive metastatic MDA-MB-231 cell line at low micromolar concentrations. In addition, it highly arrested the cells in the G2/M phase, especially the MCF-7 cell line. By contrast, evoxanthine (2) and arborinine (3) exhibited higher cytotoxicity against MCF-7 than MDA-MB- 231 and influenced the cell cycle in both cell lines by arresting some cells in the G2/M phase, preventing cells with damaged DNA from entering mitosis. Molecular docking analysis showed that all alkaloids inhibit human topoisomerase II α, compared with vosaroxin’s anti-cancer agent under clinical trial. The ADMET studies revealed that the alkaloids showed the highest drug-likeness properties, suggesting that these alkaloids act as a drug and exhibit remarkable biological activities, except (5). DFT calculations indicated that the studied alkaloids showed the lowest gap energy and were chemically reactive.Conclusion:The results obtained from molecular docking, drug-likeness properties, ADMET analysis, and DFT calculation are in good agreement with experimental studies. Hence, evoxanthine (2), arborinine (3), and evodiamine (4) may serve as lead molecules that could be developed into potent topoisomerase II α inhibitors against human breast cancer cells.
Feasibility Study on Preparation of EN-GJL-250 Rough Microstructure
Hydrophobic Surface by WEDM
Authors: Li Zhaolong , Liu Yingtao , Cao Binren , Zhu Bo , Yang Xiaodong 
Published: January 2022

Background:
Preparation of the superhydrophobic surface on the metal substrate can
effectively solve the problems of easy corrosion and easy ice coating of metal materials, and it is
given the functions of self-cleaning, oil-water separation, lubrication and drag reduction. Constructing
micro-nano rough structures and reducing surface potential energy are the key factors in preparingsuperhydrophobic
surfaces. There is no macroscopic cutting force between the electrode and
workpiece in the WEDM process, the surface roughness can be changed by controlling the energy,
and the complex shape can be manufactured by increasing the degree of freedom. The WEDM
method has broad application prospects in the preparation of the superhydrophobic surface.

Objective:
To verify the feasibility of preparing the hydrophobic surface by WEDM, the micro-nano
structure of the EN-GJL-250 (Gray cast iron material) surface was processed by the WEDM method,
and the effect of surface roughness on the hydrophobicity of the surface was studied; Simultaneously，
in the process of WEDM, the effects of peak current and pulse width on the surface roughness
and static contact angle (CAs) of the EN-GJL-250 were studied. The purpose was to improve
and control the surface hydrophobicity of the EN-GJL-250.

Methods:
The micro-nano structure was fabricated on the EN-GJL-250 surface by WEDM. Using
the single factor test, by setting different peak currents and pulse widths, the surface roughness and
CAs of the processed EN-GJL-250 can be measured.

Results:
Using the WEDM machine tool, by inserting set dimensions and regular contour parameters,
the micro-nano structure with hydrophobic properties can be machined on the EN-GJL-250
surface. Different WEDM processing parameters produce rough microstructures of different scales
and affect the hydrophobicity of the EN-GJL-250 surface. Experimental results show that with the
increase of pulse width and peak current, the surface roughness of EN-GJL-250 also increases, and
the number and size of craters in the microstructure increase, which improves the hydrophobicity of
the surface of EN-GJL-250; When the peak current is 16A and the pulse width is 32us, the CAs of
the prepared EN-GJL-250 surface is the highest.

Conclusion:
The surface roughness microstructure of EN-GJL-250 is processed by WEDM, which
can realize the hydrophobicity of the surface. The pulse width and peak current will affect the
roughness of the processed surface, thereby affecting the hydrophobic properties of the surface. The
research data in this paper provides theoretical support for the industrial production of superhydrophobic
EN-GJL-250 surfaces.
impacts contract farming on cultivation and postharvest practices on red chili farm in Magelang District, Indonesia
Authors: Angreheni Diah , Darma Rahim , Asrul Laode 
Published: January 2022

Contract farming refers is to carry out the agreement between the buyer and the farmer to reduce risk for both parties. Red chili is rotten, damaged, and has a large shrinkage, causing production, quality and price risks. The study provide an empirical analysis of the impact of contract farming on chili cultivation and postharvest practice. The field survey was conducted in Magelang District as the one of the production centers of red chillies in West Java. Data collected from 40 farmers for contract and 45 farmers for noncontract. The results of the study indicated that the cultivation and post-harvest practices on contract farmers are better in quality, as well as in quantity compared to non-contract farmers. In contract farming, cultivation and post-harvest practices done by farmers are controlled by growers as representatives of the company. Tight control over the products produced by farmers generates not only for the better quality, but also the increase chili farm productivity. Contract farming is recomended to apply other agricultural commodities, specially for high risk commodity which has wid price fluctuation, high quality variation, and susceptible to climate changes.
OS TRIBUNAIS COMO MÁQUINAS DE GUERRA DO ESTADO FASCISTA ITALIANO EM ALFREDO ROCCO E SUAS REPERCUSSÕES NO PENSAMENTO E NA ATUAÇÃO POLÍTICA DE FRANCISCO CAMPOS, O JURISTA DO ESTADO NOVO
Authors: Alves Rogério Pacheco 
Published: January 2022

O século XX é profundamente marcado pelo fascismo e pelos mais variados tipos de autoritarismo, fenômenos que vão realocar o Estado no campo da filosofia política e produzir alterações em seu interior e em suas concepções teóricas. Os Tribunais cumprem importantes papéis nessa nova arquitetura e funcionam como aparatos legais contra o dissenso político no fascismo italiano de Mussolini e no estadonovismo de Vargas, através da atuação repressora do Tribunal Especial para a Defesa do Estado (Itália) e do Tribunal de Segurança Nacional (Brasil). Como pano de fundo teórico dos novos papéis judiciais tem-se a concepção de um Estado forte baseado na ordem e na unidade e que nega a soberania popular, a criar um tipo de unidade anônima, embora se sirva das massas como plataforma de legitimação do poder que exerce. O Estado forte despreza a separação dos poderes e a democracia liberal, vistas como mitos que apenas enfraquecem a ordem estatal. Além disso, o Estado forte gravita em torno de uma personalidade carismática que produz em si um tipo de unidade espiritual entre o Estado e a sociedade. Os aparatos judiciários de exceção e a doutrina do Estado forte contam com as contribuições teóricas e práticas de Alfredo Rocco e Francisco Campos, juristas e ideólogos da exceção. Assim, o objetivo do presente trabalho é, no marco de perspectivas críticas sobre a teoria do estado e a problemática relação entre direito e política, contribuir ao aprofundamento das aproximações entre as concepções políticas do Poder Judiciário no fascismo italiano e no Estado Novo brasileiro, indo além das pesquisas que resgatam as relações de filiação entre a legislação criminal italiana da década de trinta e a legislação brasileira produzida pelo Estado Novo. Os temas propostos no presente trabalho nos permitem refletir sobre as relações entre direito e política e sobre o sistema de justiça como antiga e ainda eficiente máquina de guerra voltada à eliminação do dissenso político e da democracia.
Effect of Screen Time on Behavior of Preschoolers in Islamabad: Descriptive Cross-sectional Study
Authors: Suleman Marriam , Sughra Ume 
Published: January 2022

Background
The early years of childhood form the basis of intelligence, personality, social behavior, and the capacity to learn and nurture oneself as an adult. It is increasingly recognized that early and longer exposure to screens has adverse effects on the development of children. This research was significant in finding out the effects of screen time on the behavior of preschoolers, which could provide scientific grounds to the control of digital screen time.

Objective
We aimed to determine the effect of electronic exposure on the behavior, emotional development, and sleep quality of preschoolers and determine the average number of hours preschoolers spend with electronic devices in Islamabad.

Methods
A cross-sectional survey was conducted in 4 private preschools of Islamabad. A sample of 200 children aged 3 to 5 years was selected through multistage random sampling. The sociodemographic characteristics and screen time of the children were acquired by using parental questionnaires. Children were grouped based on a daily screen time of ≤60 minutes or >60 minutes. An analysis was conducted based on the results of the Child Behavior Checklist for children aged 1.5 to 5 years. The Cronbach α coefficient was found to be .925. It was analyzed by using SPSS version 22 (IBM Corporation). A chi-square test, an independent sample t test, and multilinear regression were applied to determine the associations and significance levels between the variables.

Results
The study results indicate that increased screen time was found to be statistically significant with regard to a child’s age, their education level, and the employment status of mothers. It was observed that preschoolers with a screen time of >60 minutes (mean 11.94, SD 3.91; P=.01) tend to more commonly experience withdrawn syndrome than those with a screen time of ≤60 minutes (mean 10.72, SD 3.01). Similarly, sleep problems were also more commonly observed in preschoolers with a screen time of >60 minutes (mean 10.97, SD 3.20; P=.01) when compared to those with a screen time ≤60 minutes (mean 9.90, SD 2.59). It was also observed that increased screen time had an association with autism spectrum problems among preschoolers with a screen time of >60 minutes (mean 17.66, SD 5.89; P=.047) when compared to those among preschoolers with a screen time of ≤60 minutes (mean 16.17, SD 4.58). The strongest predictor of the outcome variable was found to be mothers’ education level (ß=21.53).

Conclusions
The findings reveal that excessive screen time is a deleterious factor associated with the behavioral problems of preschoolers. Parents must also think about their child’s screen time. This requires parents’ active engagement and constant attention, so that the development and growth of their children are not affected adversely.
La apropiación social de tecnologías móviles, una oportunidad para la formación ciudadana
Authors: Marín Ochoa Beatriz Elena , Cruz Lanchero Luis Javier 
Published: January 2022

En la actualidad, las Tecnología de la Información y Comunicación (TIC) y los aplicativos móviles transformanla existencia de las personas; están presentes en todos los ámbitos y contextos cotidianos, de tal manera que ofrecen diversas perspectivas de abordaje para asumir retos como los que propone la educación en zonas rurales.
Con esta investigación se crea una propuesta de apropiación social de TIC por medio de estrategias de micro aprendizaje, mediados por dispositivos móviles para la formación ciudadana de estudiantes de grados decimo y once en una Institución rural del Urabá antioqueño.
La idea que surgió durante la ejecución del proyecto Ecosistema de Contenidos Digitales para Apps en Urabá, realizado entre 2019 y 2020, eligió a la Institución Educativa Rural Zapata (IERZ), que presta sus servicios en el corregimiento Zapata, Necoclí, para el trabajo de campo entre marzo y mayo de 2020, por el compromiso de la comunidad educativa y los avances en el proceso de Eduapps.
La metodología incluyó: una caracterización del nivel de apropiación frente a los dispositivos móviles y una categorización de cómo se evidencia la ciudadanía desde el ejercicio escolar cotidiano. Conocimientos que se transformaron en la propuesta de micro aprendizaje, modelo Eduapps, para fortalecer la formación ciudadana.
Como resultado, se logró demostrar que la propuesta promueve la formación y sintoniza la comunidad académica de la vereda, en función del uso de herramientas digitales móviles y apropiación de estrategiasdidácticas, para entender la importancia de asumir su propia ciudadanía con miras a construir un territorio en paz y con un real ejercicio de la democracia.
Pengaruh store atmosphere terhadap keputusan pembelian konsumen di Coffee Shop Lucky Coffee Kota Jambi
Authors: Krisito Renol Elmi , Yacob Syahmardi , Yuniarti Yenny 
Published: January 2022

This study aimed to determine the effect of store atmosphere dimensions on purchasing decisions at Lucky Coffee Jambi City coffee shop. The number of samples taken was 100 respondents using nonprobability sampling techniques and quantitative methods. Data collection was carried out by distributing questionnaires. Based on the study results, it is suggested that Lucky Coffee keep the outside variable (X1) and purchase points (X4) to increase consumer purchasing decisions on Lucky Coffee. Data were analyzed with multiple linear regression analysis using statistical software SPSS 21. The results showed that the coefficient of determination showed an R square of 0.752, which means that the store atmosphere affects purchasing decisions by 75.2%. The remaining24.8% is influenced by other factors not examined in this research. The F Store Atmosphere test involves purchasing decisions, evidenced by the F value of 71.834. In the T-test, it is known that the exterior (X1) has an effect of 5.346, the general interior (X2) is 1.315, the store layout (X3) is 0.423, and the point of purchase (X4) is 2.079. From the results of this study, it can be concluded that the Store Atmosphere on individual purchasing decisions affects the outer dimensions of the store and the purchase points. In contrast, the general interior dimensions and store layout do not significantly affect purchasing decisions.
Reef fish diversity in the Legon Bajak Port, Kemujan Island, Karimunjawa National Park
Authors: Maulany Siti Lathifah , Kurniawan Ardyan Pramudya 
Published: January 2022

Karimunjawa National Park provides substantial reef fish resources, leading to higher market demand for reef fish production. This study aims to determine the diversity of reef fish, particularly in regions where fishing boats dock, specifically in Legon Bajak Port, Kemujan Island, Karimunjawa National Park, Jepara, Central Java. The findings of this investigation should enrich previous studies. The study was conducted on the right and left sides of the Legon Bajak Port. The visual count of belt transects was used to obtain data on reef fish. The study results obtained the number of reef fish at the Legon Bajak Port was 2769 individuals/500 m2 on the right and 1809 individuals/500 m2 on the left side, representing 40 species, 26 genera, and 13 families. Istigobius rigilius had the largest density of individuals, with 233 individuals/500 m2. The fish diversity index (H') value on the right side of the Legon Bajak Port was 3.24, which includes the high category, and on the left side was 2.89, which includes the medium category. The dominance index (D) was between 0.05 and 0.06 (low), while the uniformity index (E) was between 0.74 and 0.83 (unstable in a stable community).
THE IMPLEMENTATION OF TOEFL PRACTICUM CLASS TOWARD THE RESULT OF STUDENTS’ TOEFL SCORE IN ENGLISH AND LITERATURE DEPARTMENT
Authors: Djamereng Jumharia , Yusuf Faidah , Nirwana Nirwana 
Published: January 2022

The policy of many universities regarding to the mandatory of TOEFL test for students has become a new discourse in academic circles, especially from the student's perspective. Although the standards set by each university are different, there are some similar conditions faced by students in meeting these standards such as, TOEFL becoming a burden for students, particularly those with limited English skills, moreover, it is increasing the cost of study by requiring students to pay for the test execution cost. Therefore, in line with this policy, the campus must provide support so that each student can meet the expected qualifications. This study aims to describe how the TOEFL Practicum Class is organized by the English language and literature department to help students meet the TOEFL standard set by the campus, which is 500. The experimental method in this research uses a type of research design with a pretest-posttest control design method, and the total sample used was 64 students from the fifth semester of English and literature department. this study consists of 3 stages, namely preparation stage, implementation stage and final or evaluation. stages. Based on the findings regarding to the effectiveness of the TOEFL Practicum Class implementation, it can be seen from the results of the pre-test and post-test means score, which seems to have increased toward the score of the students.
EDUCATIONAL MARKETING INFORMATION SYSTEMS AT ISLAMIC EDUCATIONAL INSTITUTIONS
Authors: Laksono Tio Ari , Sulistyorini Sulistyorini 
Published: January 2022

Abstract: Educational Marketing Information Systems at Islamic Educational InstitutionsDelays in presenting educational marketing information will cause information not to reach customers quickly and accurately. Marketing educational services is a strategy to improve the quality of education which is the most important element for the quality and progress of the level of education in an educational institution. Marketing is done so that the public knows the advantages and programs owned by the madrasa. Customer satisfaction with educational institutions is identical to customer satisfaction regarding the services provided. This type of research is library research with a qualitative approach. The research process is descriptive analysis, namely by collecting data, compiling, clarifying, and analyzing. Marketing activities can be carried out with various channels or several media, with the hope that there will be three stages of change, namely: changes in knowledge, changes in attitudes, and changes in desired actions. Educational institutions must be able to create community-oriented educational service programs that adapt to the needs of madrasas. Educational institutions must strive to create a positive image in the eyes of the community so that people can make decisions for their sons and daughters to choose the madrasa. Abstrak: Sistem Informasi Pemasaran Pendidikan pada Lembaga Pendidikan IslamKeterlambatan dalam menyajikan informasi pemasaran pendidikan akan menyebabkan informasi tidak sampai kepada pelanggan dengan cepat dan tepat. Pemasaran jasa pendidikan merupakan strategi peningkatan mutu pendidikan yang merupakan elemen terpenting bagi kualitas serta kemajuan taraf pendidikan pada suatu lembaga pendidikan. Pemasaran dilakukan agar masyarakat mengetahui keunggulan dan program-program yang dimiliki oleh madrasah. Kepuasan pelanggan terhadap lembaga pendidikan identik dengan kepuasan pelanggan mengenai pelayanan yang diberikan. jenis penelitian ini adalah penelitian kepustakaan (library research) dengan pendekatan kualitatif. Pada proses penelitiannya bersifat analisis deskriptif, yaitu dengan cara mengumpulkan data, menyusun, mengklarifikasikan, dan menganalisis. Kegiatan pemasaran dapat dilakukan dengan berbagai saluran atau sejumlah media, dengan harapan terjadinya tiga tahapan perubahan, yaitu: perubahan pengetahuan, perubahan sikap dan perubahan tindakan yang dikehendaki. lembaga pendidikan harus dapat membuat program-program layanan pendidikan yang berorientasi kepada masyarakat yang menyesuaikan dengan kebutuhan madrasah. Lembaga pendidikan harus berusaha untuk menciptakan citra yang positif dimata masyarakat sehingga masyarakat dapat membuat keputusan untuk putra dan putrinya agar memilih madrasah tersebut.
KEBERAGAMAN KRITERIA BERBAGAI ORMAS DI INDONESIA DALAM MENENTUKAN HILAL
Authors: Ihsani Ma’dinal 
Published: January 2022

Hilal is the visible crescent phenomenon that appears from the Earth's surface after the ijtima. The appearance of the hilal is inevitable after the ijtima event of the Sun and Moon in one astronomical longitude at each end of the month toward the beginning of the month. This raises some perspectives among experts, whether the hilal is visible and can be seen or not. It is not uncommon controversy for each other because they have not found agreement in the interpretation of the hilal. In Indonesia, each Islamic mass organization has different ways of determining the hilal or what is often termed rukyatul hilal. Keyword: fiqh, NU, Muhammadiyyah, LDII, HTI, rukyat, hilal
PERANAN ILMU HISAB DALAM PENENTUAN WAKTU IMSAKIAH DI KABUPATEN GOWA
Authors: Aisyah Nur 
Published: January 2022

Ilmu Hisab atau yang biasa disebut dengan ilmu falak tidak hanya berguna untuk penguasaan dan pengembangan ilmu pengetahuan dan teknologi dalam bidang astronomi, tetapi juga untuk keperluan yang berkaitan dengan masalah-masalah ibadah umat Islam seperti salat, puasa dan haji. Serta dalam penentuan arah kiblat, penentuan waktu salat, penentuan awal bulan kamariah, hari-hari besar Islam, dan untuk penentuan saat terjadinya peristiwa gerhana (bulan dan matahari), serta penentuan waktu imsakiah dalam bulan Ramadan. Dalam bulan Ramadan kita mengenal waktu imsak. Secara bahasa Imsak bermakna menahan. Yaitu, waktu tertentu sebelum subuh saat kapan biasanya kaum Muslimin mulai menahan dari makan dan minum. Pada beberapa masjid di Kab. Gowa dalam menentukan waktu imsak hampir setiap masjid menggunakan pengumuman stasiun RRI yang diumumkan setiap hari pada bulan Ramadhan yang berpatokan pada waktu Kota Makassar. Hal ini tentu saja berbeda dengan waktu Kabupaten Gowa yang berbeda lintang dan bujur dengan Kota Makassar. Perbedaan tersebut tentu saja berpengaruh terhadap masuknya awal waktu salat dan jadwal imsakiah yang dkeluarkan oleh Kementerian Agama Kab. Gowa Kata Kunci : Ilmu Hisab, Imsak