bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of water-soluble pristine C60 fullerene on 6-OHDA-induced Parkinson’s disease in rats
Authors: Stetska V. O. , Dovbynchuk T. V. , Makedon Y. S. , Dziubenko N. V. 
Published: January 2022

Oxidative stress is thought to be one of the mechanisms that leads to the dysfunction and degeneration of dopaminergic neurons in Parkinson’s disease pathogenesis and presumed to be underway during the prodromal phase. Therefore, therapy, which is effective against pre-motor symptoms, might be effective in preventing or delaying the development and progression of Parkinson’s disease. The aim of our study was to investigate the therapeutic efficiency of pristine C60 fullerene aqueous solution (C60FAS) during Parkinson’s disease in rats. The unilateral dopamine deficiency was induced in male Wistar rats (220–250 g) by stereotaxic microinjection of neurotoxin 6-hydroxydopamine (6-OHDA, 12 μg). C60FAS was injected to rats intraperitoneally daily for 10 days (0.65 mg/kg per day). The percentage of destroyed dopaminergic neurons was determined by the apomorphine test and by IHC staining of tyrosine hydroxylase-positive neurons in substantia nigra. We evaluated the rat body weight, the water and food intake, Open Field behavioural test, the level of biochemical antioxidant system, the activity of peritoneal macrophages. Levels of spontaneous and carbachol-stimulated colon motility were estimated by ballonographic method in vivo. C60FAS showed a positive tendency to increase the number of tyrosine hydroxylase-positive cells in the midbrain, which was associated with more profound improvement in apomorphine-rotation behaviour and slight relief of the anxiety level in Open Field test. Furthermore, C60FAS treatment increased the index of stimulated distal colon motor activity while it did not have a significant effect on water content in feces and total gastrointestinal transit time. C60FAS treatment did not affect water intake behaviour or body weight changes while it induced an increase of glutathione level and decrease activity of glutathione peroxidase in the brain as well as an increase in activity of peritoneal macrophages in 6-OHDA-Parkinson’s disease rats. These findings confirmed the potential therapeutic effectiveness of water-soluble pristine C60 fullerene in Parkinson’s disease pathogenesis, though there is ground for caution because of its systemic mild toxic effect.
Pathomorphological changes in the organs of chickens infected spontaneously by the species Salmonella pullorum on private farms in Chernivtsi region
Authors: Shchebentovska O. , Kostynuk A. , Zaika S. , Kovalova L. , Yevtukh L. , Holubtsova M. 
Published: January 2022

Commercial poultry production growth and the increase in the number of small farms specializing in raising broiler chickens, laying hens, quails, and other poultry contribute to the spread of infectious diseases. Non-compliance with the principles of biosafety during incubation and breeding results in mass deaths of poultry and, consequently, significant economic losses for farmers. Salmonellosis is one of the most dangerous anthropozoonotic diseases of poultry, which is most often registered in private farms. Age analysis of the poultry salmonellosis in the EU countries indicates the infection of adult laying hens most often, young poultry to a lesser extent, and chickens aged up to 10 days less frequently. Although the program for the prevention and elimination of poultry salmonellosis has been approved at the legislative level in Ukraine, monitoring studies are not carefully conducted. This is especially true for private homesteads and small farms, which greatly complicates the epizootiological situation in some regions of the country. The article describes the pathological and histological changes in the liver, heart, lungs, kidneys, and spleen. The changes were detected in chickens aged 10 and 14 days infected with microorganisms of the species Salmonella pullorum. Eggs for incubation were obtained from different family flocks, and incubation was performed in a single incubator. The initial clinical signs of the disease appeared in chickens aged 7 days and included diarrhea, increased water consumption, lameness, mass concentration of chickens near heat sources, nervous phenomena in the form of circle walking, and partial blindness in some cases. The pathological autopsy revealed hepatomegaly with sharp change in the organ colour, diapedetic hemorrhage under Glisson’s capsule, and diffuse miliary necrosis. Greyish-white nodular lesions of the lungs and heart, dystrophic changes in the kidneys, and deposition of uric acid salts in the ureters were also characteristic features. Diffuse coagulation necrosis, massive perivascular infiltration by heterophilic lymphocytes and stasis were observed in the liver. Changes in the heart were characterized by significant infiltration by mononuclear cells and heterophiles, which led to atrophy, necrosis, and replacement of cardiomyocytes by connective tissue cellular elements. Delymphatization and necrosis of the lymph nodes were pronounced in the spleen.
Specifics of the morphological identification of the pathogen of passaluariasis of rabbits
Authors: Khorolskyi A. , Yevstafieva V. , Kravchenko S. , Pishchalenko M. , Vakulenko Y. , Gutyj B. 
Published: January 2022

Passalurus ambiguus (Nematoda, Oxyuroidae) is one of the most common parasites of digestive tract of domestic and wild rabbits and rodents. Passalurus spp. are cosmopolitan, and the mature nematodes are localized in the appendages and large intestine of animals. The passaluariasis infections remain quite relevant in modern rabbit breeding, because the disease is highly contagious, with the possibility of unlimited spread inducing significant economic losses. The aim of the study was to determine the identifying morphological species characteristics of P. ambiguus nematodes, which were isolated from the colon of domestic rabbits (Oryctolagus cuniculus domesticus). The identifying characters of Passalurus include morphological features, namely the presence of a spherical bulb in the esophagus, and the presence of three teeth in the oral capsule. Males of P. ambiguus have a characteristic structure of the tail end, namely the presence of papillary protrusions and a massive narrowed part with a spicule handle, and five papillae around the cloaca. Twenty-eight metric indicators are proposed that characterize the size of the body, oral capsule, esophagus in different parts of it, the tail end, spicules, the location of the cloaca. Two different morphotypes of mature females of P. ambiguus were revealed – short-tailed and long-tailed, which were larger by 19 indicators (by 3.2–43.6%). The morphotypes of P. ambiguus females are characterized; the length of the tail, body length and width in different areas, depth of the oral capsule, esophageal size and its structural elements, the location of the vulva and nerve ring, the width of the caudal process. At the same time, the parameters of esophageal bulb length and caudal process in short-tailed females were higher (by 13.9% and 11.9%, respectively) than in the long-tailed females. A total of 25 morphometric parameters were proposed for the identification of P. ambiguus females. The obtained data indicate the feasibility of further research on the causes of occurrence of such morphotypes in P. ambiguus females and the need to take into account the existence of such forms of females for their differential diagnosis taking into account their proposed morphometric parameters.
Effective Functioning of a Mixed Heterogeneous Team in a Collaborative Robotic System
Authors: Galin Rinat , Shiroky Alexander , Magid Evgeni , Meshcheryakov Roman , Mamchenko Mark 
Published: January 2022

The study describes a collaborative robot (cobot) as one of the types of intelligent robotics and its distinctive features compared to other types of robots. The paper presents a collaborative robotic system as a single complex system in which actors of different types – cobots and human workers – perform collaborative actions to achieve a common goal. Elements of a collaborative robotic system, as well as processes and entities that directly influence it are represented. The key principles of Human-Robot Collaboration are described. A collaborative robotic system is analyzed both as a multi-agent system and as a mixed team, whose members are heterogeneous actors.
The relevance of the work lies in a weak level of research on issues of formation of mixed teams of people and cobots and distribution of tasks in such teams, taking into account features of these two types of participants and requirements of their safe collaboration. This work focused on a formation of mixed teams of elements of a single complex human-cobot system, the distribution of tasks among the members of such teams, taking into account the need to minimize costs for its participants and the heterogeneity of the team. As part of the study, the problem of forming a mixed heterogeneous team of people and cobots, and distribution of work among its members, as well as the corresponding mathematical description are presented. Specific cases of the problem, including different cost functions of different types of participants, a limited activity of the team’s members, the dependence of the cost function of the participants of one type on the number of participants of another type, as well as an arbitrary number of works assigned to the team’s members are considered.
Evaluation of the efficiency of a new pulsatile flow‑generating circulatory-assist system in rotary blood pumps. Research on a mathematical model
Authors: Itkin G. P. , Syrbu A. I. , Kyleshov A. P. , Buchnev A. S. , Drobyshev A. A. 
Published: January 2022

Objective: to study the effect of a pulsatile flow-generation (PFG) device on the basic hemodynamic parameters of the circulatory system using a mathematical model.Results. Modelling and simulation showed that the use of PFG significantly (76%) increases aortic pulse pressure. The proposed mathematical model adequately describes the dynamics of the circulatory system and metabolism (oxygen debt) on physical activity in normal conditions and heart failure, and the use of non-pulsatile and pulsatile circulatory-assist systems. The mathematical model also shows that the use of PFG device blocks the development of rarefaction in the left ventricular cavity associated with a mismatch of blood inflow and outflow in diastolic phase when there is need to increase systemic blood flow by increasing the rotary pump speed.
The incidence and risk factors of chronic rejection in acutely rejected pediatric liver transplantation
Authors: Dehghani S. M. , Shahramian I. , Ayatollahi M. , Parooie F. , Salarzaei M. , Bahmanyar M. , Sargazi A. , Delaramnasab M. 
Published: January 2022

Background. Chronic graft rejection (CR) represents an increasing concern in pediatric liver transplantation (LT). Risk factors of CR in this population are uncertain. In present study, we aimed to ascertain if clinical parameters could predict the occurrence of CR in LT children.Methods. We retrospectively analyzed the results from 47 children who had experienced acute hepatic rejection in Namazee hospital, Shiraz, Iran during 2007–2017.Results. Out of 47 children, 22 (46.8%) and 25 (53.2%) were boys and girls respectively. Ascites, gastrointestinal bleeding, and spontaneous bacterial peritonitis were observed in 20 (44.4%), 14 (31.1%), and 4 (9.1%) respectively. Posttransplant vascular and biliary complications were observed in 3 (7%) and 4 (9.3%) cases respectively. The mean time from LT to normalization of liver enzymes was 14.2 ± 7.5 days. The mean of acute rejection episodes was 1.4 ± 0.6 (median = 1 (22, 46.8%), range of 1–3). Six (12.7%) patients experienced CR. The mean time from LT to CR was 75 ± 28.4 days. A significant association was found between CR and patients’ condition (being inpatient or outpatient) before surgery (P = 0.03). No significant relationship was found between CR and post-transplant parameters except for biliary complications (P = 0.01). Both biliary complication (RR = 33.7, 95% CI: 2.2–511, P = 0.01) and inpatient status (RR = 10.9, 95% CI: 1.1–102.5, P = 0.03) significantly increased the risk of CR.Conclusion. Being hospitalized at the time of LT, and development of biliary complications might predict risk factors for development of CR in LT children.
Changes in glomerular filtration rate in liver recipients after reduced exposure to calcineurin inhibitors with concomitant everolimus administration within the first year after immunosuppression conversion
Authors: Syutkin V. E. , Salienko A. A. , Zhuravel S. V. , Novruzbekov M. S. 
Published: January 2022

Objective: to compare changes in estimated glomerular filtration rate (eGFR) in liver recipients with initially normal and impaired eGFR within the first year after immunosuppression conversion.Materials and methods. Enrolled in the study were 215 recipients of deceased-donor livers from February 2009 to February 2020, who received everolimus with dose reduction or complete withdrawal of calcineurin inhibitors (immunosuppression conversion, ISxC) for varying periods of time. GFR was measured using the MDRD-4 formula immediately before ISxC, then 3, 6, and 12 months after orthotopic liver transplantation (LTx). One month was considered an acceptable temporary deviation from the corresponding point.Results. At the time of ISxC, 32 (15%) of 215 recipients had normal renal function. Chronic kidney disease (CKD) increased in 60% of the recipients with normal eGFR by the end of the first year following ISxC; the fall in eGFR was particularly pronounced in older recipients. In the group with a baseline eGFR of 60–89 mL/min/1.73 m2, eGFR normalized in 62% of cases within 12 months; 28% of cases had no changes in renal function. In the subgroup with a pronounced decrease in eGFR at the time of ISxC, increased eGFR was observed as early as 1 month after ISxC, and the maximum was recorded after 3–6 months. The mean eGFR relative to baseline by month 3 after eGFR were higher for ISxC that was done in the first 2 months after LTx (19.7 ± 15.7 ml/minute/1.73 m2) than for ISxC done in the long-term period after LTx (10.1 ± 8.7 ml/minute/1.73 m2, p < 0.05).Conclusion. Changes in eGFR in liver recipients receiving EVR plus low-dose calcineurin inhibitor (CNI) depend on baseline eGFR and are multidirectional. The use of ISxC in the early post-LTx period led to a more pronounced improvement in eGFR. Maximal changes in eGFR were observed by 3–6 months after ISxC.
Substantiation of Approaches to the Analysis and Assessment of the Eﬀectiveness of Participants in the Implementation of Diversifcation Programs.
Authors: Pisareva O. M. 
Published: January 2022

Purpose: of the article is to substantiate conceptual approaches to the formation of a toolkit for assessing the eﬀectiveness of participants in the development and implementation of diversifcation programs for enterprises of the military-industrial complex in the context of digital transformation of management.Methods: the research methodology is based on general economic approaches to studying the problems of the efciency of economic activity of economic entities and special approaches to the formation of complex systems for analyzing and assessing the eﬀectiveness and efciency of the activities of project management participants in the process of developing and implementing programs for the diversifcation of the defense industry. The basis of the methodology is the concept of performance management in the context of digital transformation of management.Results: the article presents the key provisions and the main results of the study, obtained on the basis of studying the materials of scientific publications and open information sources in the subject area under consideration using the methods of logical, content and statistical analysis. Based on the specifcs of diversifcation programs, it is proposed to use the provisions of the performance management concept as a theoretical basis for the formation of a tool for assessing the activities of their participants. An integral multiplicative criterion of efciency for a comprehensive assessment of activities is proposed. It is built on the indicators of fve aspects of assessing the performance of participants in diversifcation programs. These aspects assess the completenes s of the organizational and methodological support of the diversification process, the consolidated eﬀectiveness and efciency of the program activities, the quality of management, as well as the fnancial security of the implementation of the diversifcation program activities.Conclusions and Relevance: a scenario approach to substantiating the parameters of the incentive mechanism in the model of coordinated activity of the participants in the implementation of the diversifcation program is proposed, which takes into account the assessment of its commercial parameters. The results presented in the article are useful in the development of methodological support for assessing the eﬀectiveness and organizing incentives for participants in diversifcation programs in the context of the formation of a digital ecosystem for managing enterprises of the military-industrial complex.
Assessment of Risks and Threats of "Green" Entrepreneurship based on Cross-Factor Modeling
Authors: Kozhevinа O. V. , Belyaevskaya-Plotnik L. A. 
Published: January 2022

The article is a continuation of a number of scientifc studies conducted by the authors within the framework of government assignments and grants, dedicated to identifying the relationship between the economic security of territories and the development of "green" entrepreneurship on them.Purpose: of the study is to model the assessment of the state of economic security of territories under various conditions of the transition to "green" entrepreneurship, taking into account the action of external and internal factors. "Green" entrepreneurship is a priority area for the development of Russian regions, consistent with the achievement of Russia's national strategic goals for the period up to 2030.Methods: in this work, cross-factor modeling and the method of integral analysis are used to calculate the composite index of the state of economic security and its structural components, taking into account the development of "green" entrepreneurship, supplemented by the method of a priori ranking of factors to assess the contribution of each component and justify the priority the selected factors aﬀecting the level of economic security of the regions.Results: a three-component cross-factor model for assessing the state of economic security in certain regions of the Russian Federation (Moscow Region, Leningrad Region, Sverdlovsk Region, Novosibirsk Region, Altai Territory, Krasnodar Territory) had been calculated and tested. The regions were ranked according to the value of each of the components, as well as separately according to the aggregate level of economic security. The necessity of stimulating the development of "green" entrepreneurship in each of the analyzed regions. Have been substantiated and stimulating and discouraging factors that have an impact on the level of economic security, taking into account "green" entrepreneurship, pointwise in each subject, have been identifed.Conclusions and Relevance: the proposed approach to assessing the impact of the identifed factors on the level of economic security of the regions, taking into account the development of "green" entrepreneurship on the basis of the developed cross-factor model, made it possible to build a rating of territories and identify stimulating and discouraging factors in their development. On the basis of which to determine the tools for inﬂuencing the economic security in a separate entity.
Digital Institutional Transformation of Electronic Trading Platforms in the Field of Public Procurement of the Russian Federation
Authors: Bizhoev B. M. 
Published: January 2022

Purpose: the aim of the article is to calculate the reduction in transaction costs when transferring purchases to electronic format, as well as determine the potential for digitizing the consideration of all requirements for procurement participants.Methods: the study is based on the conceptual provisions of the institutional economic theory, the use of the system approach methodology, the use of survey research methods, and the generalization of expert assessments. The development of the proposed topic is also based on the use of methods of economic and statistical analysis, scientifc abstraction, comparison and scientifc generalizations.Results: as a result of a detailed analysis, the digital transformation electronic trading platforms into the digital trading platforms was substantiated. The paper also shows the role of electronization and digitalization in reducing transaction costs and time spent on customers. It was revealed that the transfer of authority to the electronic trading platforms not only excludes the possibility of errors, unfair and opportunistic behavior of customers, and as a result – the imposition of fnes, but also reduces the time spent on procurement. The main approaches to improving the contract system, building its digital ecosystem, where the necessary actions are performed by the software and hardware complex, and the contract manager only "accompanies" the purchase, are proposed. The article presents the evolution of the use of digital technologies and the corresponding legal regulation in Russia.Conclusions and Relevance: the use of digital technologies in public procurement is becoming a factor causing changes in the contractual system. The electronic form of trading has brought a new reality, opportunities for digital transformation are opening up. The use of automated counterparty verifcation technologies in the activities of electronic trading platforms is a potential factor in reducing transaction costs. In the future, it is possible to use digital technology “big data”, which helps to identify and categorize the necessary information regarding the availability of experience in the execution of similar contracts.