bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Copywriting Media Sosial Pada Yayasan Dharma Kasih Jakarta Utara
Authors: Hartini Sari , Murtina Hidayanti , Muryani Sri , Serli Rosi Kusuma 
Published: October 2022

Yayasan Dharma Kasih Jakarta timur merupakan yayasan sosial yang didirikan karena sebuah keprihatinan lingkungan dimana banyak terdapat anak-anak terlantar baik karena terlahir dari keluarga tidak mampu maupun karena anak yatim/piatu yang mempunyai tujuan untuk membantu meringankan kebutuhan mereka, YDKJT mempunyai cita-cita agar dapat membantu pemerintah dalam menangani masalah sosial salah satunya adalah anak-anak terlantar , dengan orientasi kegiatannya adalah dibidang kegiatan Pendidikan,Sosial /kemanusiaan, Kesehatan dan agama.Untuk mencapai tujuan YDKJT dalam mengumpulkan masyarakat yang peduli dan prihatin dengan permasalahan bangsa ini, dan ingin turut andil membantu pemerintah dalam menangani masalah anak-anak terlantar.Salah satu strategi yang penting adalah melalui sosialisasi dengan tampilan-tampilan visual yang disesuaikan dengan karakter pada Yayasan Dharma Jakarta Timur (YDKJT), target utama promosinya yaitu seluruh masyarakat indonesia Pengenalan atau promosi Profile Yayasan berguna sebagai sarana mempromosikan layanan dan kegiatan apa saja yang terdapat pada Yayasan Dharma Jakarta Timur (YDKJT), Permasalahan yang dihadapi adalah keterbatasan pengetahuan mereka untuk pemanfaatan teknologi komputer terutama memanfaatkan internet sebagai sarana untuk memperkenalkan atau promosi dari Profile Yayasan serta maksud dan tujuan dari Yayasan Dharma Kasih Jakarta timur dalam bentuk content yang menarik yang dapat dilihat melalui social media. Sebagai solusi untuk menambah pengetahuan mereka akan strategi promosi profile Yayasan dalam bentuk content yang menarik melalui social media, pemanfaatan teknologi computer dan internet maka diselenggarakanlah pengabdian masyarakat berupa pelatihan copywriting untuk membantu dalam membuat promosi profile Yayasan yang menarik melalui social media, yang bertujuan untuk memperkenalkan kepada masyarakat Indonesia profile dan kegiatan dari Yayasan Dharma Kasih Jakarta Timur.
Pelatihan Optimalisasi Website Sebagai Media Publikasi Pada Yayasan Dharma Kasih Jakarta Timur
Authors: Badrul Mohammad , Budihartanti Cahyani , Septiana Laila , Dewi Yumi Novita 
Published: October 2022

Kehadiran internet telah menghapus jarak terhadap akses informasi yang diperlukan untuk kebutuhan masyarakat. Meningkatnya kebutuhan masyarakat akan penggunaan sistem informasi, menyebabkan meningkat pula kebutuhan dalam bidang pembuatan website. Penyedia produk dan jasa menjadi salah satu media yang saat ini semakin banyak digunakan oleh masyarakat untuk menghabiskan waktu maupun mencari informasi yang sedang dicari, maka dari itu peran dari sebuah website bisa dikatakan menjadi salah satu media promosi yang berbentuk digital jika yang ditawarkannya adalah produk dan jasa yang ingin melebarkan target pasarnya. Yayasan Dharma Kasih merupakan Yayasan yang terbentuk dari timbulnya rasa keprihatinan di lingkungan yang melihat banyak anak-anak yang terlantar yang disebabkan terlahir dari keluarga yang tidak mampu ataupun anak-anak yatim atau piatu. Setiap kegiatan yang dilakukan oleh Yayasan Dharma Kasih, semua dana bersumber dari para donatur. Oleh karena itu untuk memperoleh sumber dana yang berasal dari berbagai kalangan, diperlukan publikasi yang lebih luas ke khalayak ramai agar berbagai pihak dapat mengetahui keberadaan Yayasan dengan memanfaatkan website Yayasan Dharma Kasih yang sudah ada. Tentunya butuh pelatihan tentang optimalisasi website yang ada di Yayasan tersebut. Metode pelaksanaan yang digunakan yaitu workshop tentang optimalisasi website. Hasil kegiatan ini para peserta pelatihan mendapatkan pengetahuan dan ilmu tentang perencanaan website meliputi pembuatan page layout, penentuan fasilitas website, rancangan tampilan, mock-up, sampai dengan struktur konten. Adapun hasil kuesioner menunjukkan 72 % peserta merasa puas terhadap materi dan penyampaian tutor, 80% peserta menyatakan sangat bermanfaat atas kegiatan ini, dan 80% akan berpartisipasi kembali di kegiatan pengabdian masyarakat selanjutnya.
PENGARUH PEMBERIAN TABLET FE DENGAN SARI KACANG HIJAU TERHADAP PENINGKATAN HB PADA IBU HAMIL DI WILAYAH KERJA PUSKESMAS DUNGALIYO
Authors: Harismayanti Harismayanti , Lihu Fahmi A. 
Published: October 2022

Anemia is the most severe level of iron deficiency and occurs when hemoglobin (Hb) concentrations are far below the threshold determined as anemia. One of the greatest causes of maternal death is anemia or iron (Fe) deficiency. Has been found one way to deal with nutritional anemia, especially in pregnant women, is through supplementing Fe tablets and increasing the intake of Fe food sources, green bean extract. This research was conducted in Dungaliyo Health Center. The purpose of this study was to identify the effect of giving Fe tablets and green bean extract to increase hemoglobin (Hb) level in pregnant women. The researcher used quasi experimental design with two group pre-test - post test. Samples were 34 pregnant women who were taken by using total sampling techniques. This research instrument was a Hb measurement questionnaire. Statistical tests using T-t test dependent on the increase in Hb in pregnant women before and after the intervention with level of significancy 0,000 (p-value < 0,05). The result showed that there is an effect of giving Fe tablets with green bean extract to increase hemoglobin in women at Dungaliyo Community Health Center.
EVALUASI IMPLEMENTASI STRATEGI PEMASARAN CAFÉ KOPI LUWAK MATARAM KOTA YOGYAKARTA
Authors: Chasanah Uswatun , Grenia Feza 
Published: October 2022

Penelitian ini bertujuan untuk mengetahui strategi pemasaran yang diterapkan di Café Kopi Luwak Mataram. Metode yang digunakan dalam penelitian ini yaitu metode kualitatif yang bersifat deskriptif. Adapun sumber data yang digunakan adalah data primer dan data sekunder yang kemudian data akan dianalisis mulai dari pengumpulan data, reduksi data, penyajian data hingga penarikan kesimpulan.
Berdasarkan analisis data yang dilakukan, diperoleh kesimpulan bahwa Café Kopi Luwak Mataram sudah mengetahui dan menerapkan strategi pemasaran dalam usahanya meskipun belum optimal serta marketing mix yang dilakukan terdiri dari 4P (price,product,place,promotion) serta kualitas pelayanan. Untuk produk yang dijual cukup bervariasi, untuk harga yang diterapkan Café Kopi Luwak Mataram sudah cukup bersaing, sedangkan untuk tempat kurang strategis, dan untuk promosi yang diterapkan Café Kopi Luwak Mataram kurang gencar, tetapi dari segi kualitas pelayanan Café Kopi Luwak Mataram sangat baik, sehingga membuat konsumen betah dan nyaman untuk berada di Café Kopi Luwak Mataram. Untuk solusi yang diterapkan Café Kopi Luwak Mataram harus meningkatkan kembali promosi penjualan agar lebih baik untuk kedepannya.
The association between heart failure and risk of fractures: Pool analysis comprising 260,410 participants
Authors: Liu Xiao-peng , Jian Xian-yu , Liang Dong-liang , Wen Jian-xiong , Wei Yi-hong , Wu Jian-di , Li Yi-Qun 
Published: October 2022

BackgroundHF and osteoporosis shared many common etiological risk factors. However, studies exploring whether patients with HF were associated with a higher risk of osteoporotic fracture resulted in inconsistent findings. This meta-analysis aimed to summarize the association between HF and the risk of incident fracture.MethodsFollowing the Meta-analysis of Observational Studies in Epidemiology group recommendations, we searched multiple electronic databases (PubMed, Cochran Library, and EMBASE) for related studies from inception to April 30, 2021. Studies evaluating the risk of incident fracture in patients with HF compared with those without HF were included for analysis. The random-effects models were used to combine the estimated hazard ratios (HRs) of incident fracture associated with HF.ResultsWe included 8 observational studies for meta-analysis. The sample size ranged from 5,613 to 87,748 participants, with a total of 260,410 participants included. The median follow-up duration was 5.0 years. Random-effects model analyses showed that compared with control groups, patients with HF were associated with a higher risk of all incident fractures (HR = 1.67, 95% CI = 1.30–2.16, P &lt; 0.001) and hip fracture (HR = 2.20, 95% CI = 1.28–3.77, P &lt; 0.001). The risk of all incident fractures was increased in all subgroup analyses according to age, sample size, sex, and follow-up duration.ConclusionsPatients with HF were associated with a higher risk of incident fracture, as well as hip fracture.
Washout DNA copy number analysis by low-coverage whole genome sequencing for assessment of thyroid FNAs
Authors: Wu Linfeng , Zhou Yuying , Guan Yaoyao , Xiao Rongyao , Cai Jiaohao , Chen Weike , Zheng Mengmeng , Sun Kaiting , Chen Chao , Huang Guanli , Zhang Xiaogang , Zhai Lijuan , Qian Ziliang , Shen Shu-rong 
Published: October 2022

BackgroundPapillary thyroid microcarcinoma (PTMC) is defined as a papillary carcinoma measuring ≤ 10 mm. The current management of PTMC has become more conservative; however, there are high-risk tumor features that can be revealed only postoperatively. For thyroid cancer, BRAF mutations and somatic copy number variation (CNV) are the most common genetic events. Molecular testing may contribute to clinical decision-making by molecular risk stratification, for example predicting lymph node (LN) metastasis. Here, we build a risk stratification model based on molecular profiling of thyroid fine needle aspiration (FNA) washout DNA (wDNA) for the differential diagnosis of thyroid nodules.MethodsFifty-eight patients were recruited, FNA wDNA samples were analyzed using CNV profiling through low-coverage whole genome sequencing (LC-WGS) and BRAF mutation was analyzed using quantitative PCR. FNA pathology was reported as a Bethesda System for Reporting Thyroid Cytopathology (BSRTC) score. Ultrasound examination produced a Thyroid Imaging Reporting and Data System (TIRADS) score.ResultsIn total, 37 (63.8%) patients with a TIRADS score of 4A, 13 (22.4%) patients with a TIRADS score of 4B, and 8 (13.8%) patients with a TIRADS score of 4C were recruited after ultrasound examination. All patients underwent FNA with wDNA profiling. CNVs were identified in 17 (29.3%) patients. CNVs were frequent in patients with a BSRTC score of V or VI, including eight (47.1%) patients with a score of VI and five (29.4%) with a score of V, but not in patients with a score of III, II, or I (0%). BRAF mutation was not significantly correlated with BSRTC score. LN metastasis was found more frequently in CNV-positive (CNV+) than in CNV-negative (CNV–) patients (85.7% vs. 34.6%, odds ratio = 11.33, p = 0.002). In total, three molecular subtypes of thyroid nodules were identified in this study: 1) CNV+, 2) CNV– and BRAF positive (BRAF+), and 3) CNV– and BRAF negative (BRAF–). For the CNV+ subtype, 10 (83.3%) lesions with LN metastasis were found, including four (100%) small lesions (i.e. ≤ 5 mm). For the CNV– and BRAF+ nodules, LN metastases were detected in only seven (60.0%) larger tumors (i.e. &gt; 5 mm). For CNV– and BRAF– tumors, LN metastasis was also frequently found in larger tumors only.ConclusionsIt is feasible to identify high-risk LN metastasis thyroid cancer from FNA washout samples preoperatively using wDNA CNV profiling using LC-WGS.
Landscape of RNA-binding proteins in diagnostic utility, immune cell infiltration and PANoptosis features of heart failure
Authors: Li Jie , Zhang Xueqin , Ren Peng , Wu Yu , Wang Yaoguo , Zhou Wenzheng , Wang Zhao , Chao Peng 
Published: October 2022

Objective: Heart failure remains a global public health problem linked to rising morbidity and mortality. RNA-binding proteins (RBPs) are crucial regulators in post-transcriptionally determining gene expression. Our study aimed to comprehensively elucidate the diagnostic utility and biological roles of RBPs in heart failure.Methods: Genomic data of human failing and nonfailing left ventricular myocardium specimens were retrieved from the GEO datasets. Heart failure-specific RBPs were screened with differential expression analyses, and RBP-based subtypes were clustered with consensus clustering approach. GSEA was implemented for comparing KEGG pathways across subtypes. RBP-based subtype-related genes were screened with WGCNA. Afterwards, characteristic genes were selected through integrating LASSO and SVM-RFE approaches. A nomogram based on characteristic genes was established and verified through calibration curve, decision curve and clinical impact curve analyses. The abundance of immune cell types was estimated with CIBERSORT approach.Results: Heart failure-specific RBPs were determined, which were remarkably linked to RNA metabolism process. Three RBP-based subtypes (namely C1, C2, C3) were established, characterized by distinct pathway activities and PANoptosis gene levels. C2 subtype presented the highest abundance of immune cells, followed by C1 and C3. Afterwards, ten characteristic genes were selected, which enabled to reliably diagnose heart failure risk. The characteristic gene-based nomogram enabled to accurately predict risk of heart failure, with the excellent clinical utility. Additionally, characteristic genes correlated to immune cell infiltration and PANoptosis genes.Conclusion: Our findings comprehensively described the roles of RBPs in heart failure. Further research is required for verifying the effectiveness of RBP-based subtypes and characteristic genes in heart failure.
Magnitude of second-trimester-induced abortion and associated factors among women who received abortion service at public hospitals of Arba Minch and Wolayita Sodo towns, southern Ethiopia: A cross-sectional study
Authors: Abebe Mesfin , Mersha Abera , Degefa Nega , Molla Wondwosen , Wudneh Aregahegn 
Published: October 2022

IntroductionSecond-trimester abortion accounts for 10–15% of all induced abortions, with varying rates across countries, and is responsible for two-thirds of major abortion complications. It is also associated with higher medical costs, morbidity, and mortality rates than first-trimester abortion. Even though it is a significant burden, there is a lack of adequate information about second-trimester-induced abortion, especially in the study area. As a result, the primary purpose of this study is to fill this research gap and assess the magnitude and associated factors of second-trimester-induced abortion in the public hospitals of Arba Minch and Wolayita Sodo towns, southern Ethiopia.MethodsA facility-based cross-sectional study was conducted. Systematic sampling was used to select 353 study participants. Data were collected through face-to-face interviews using a structured questionnaire and record review by using Kobo collect version 3.1. Analysis was done by STATA 14. Logistic regression was used to identify associated factors of the second-trimester-induced abortion.ResultsThe magnitude of second-trimester-induced abortion in the study setting was 23% (95%CI: 18.5%, 27.4%). The factors associated with second-trimester-induced abortion among women received abortion care services were respondent's age 25–29 and 30–34 years old (AOR = 0.38, 95%CI:0.15, 0.96 and (AOR = 0.31, 95%CI:0.10, 0.97, respectively), planned pregnancy (AOR = 0.22, 95%CI:0.11, 0.44), and delay confirming pregnancy (AOR = 2.21, 95%CI:1.15, 4.23).ConclusionThis study showed that more than one-fifth of women who presented for abortion care services had second-trimester-induced abortions. Health institution organizations working on maternal health at various levels should provide counseling to women to help them early confirm their pregnancy and make decisions about whether or not to continue it as early as possible.
High systemic inflammation score is associated with adverse survival in skull base chordoma
Authors: Li Mingxuan , Bai Jiwei , Xiong Yujia , Shen Yutao , Wang Shuai , Li Chuzhong , Zhang Yazhuo 
Published: October 2022

BackgroundThe systemic inflammation score (SIS), based on preoperative lymphocyte to monocyte ratio (LMR) and albumin (ALB), was recently developed and is demonstrated to be a novel prognostic indicator in several cancers. However, data discussing the utility of SIS in chordoma are lacking. We aimed to investigate the distribution and the prognostic role of SIS in primary skull base chordoma patients undergoing surgery.Material and methodsPreoperative SIS was retrospectively collected from 183 skull base chordoma patients between 2008 and 2014 in a single center. Its associations with clinical features and overall survival (OS) were further analyzed. The SIS-based nomogram was developed and evaluated by the concordance index (C-index), time-dependent receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA).ResultsThe numbers of patients in the SIS 2, 1, and 0 group were 29 (15.8%), 60 (32.8%), 94 (51.4%), respectively. High SIS was associated with older age (p = 0.008), brainstem involvement of tumors (p = 0.039), and adverse OS (p &lt; 0.001). Importantly, multivariate Cox analysis showed that high SIS independently predicts adverse OS. Furthermore, the nomogram based on SIS and clinical variables showed eligible performance for OS prediction in both training and validation cohorts.ConclusionsThe SIS is a promising, simple prognostic biomarker, and the SIS-based nomogram serves as a potential risk stratification tool for outcome in skull base chordoma patients.
Combined endoscopic transethmoid and transconjunctival en bloc resection of optic nerve tumors in patients lacking functional vision
Authors: Shi Jieliang , Tu Yunhai , Xu Mingna , Wu Wencan 
Published: October 2022

BackgroundSurgical treatment of optic nerve tumors is challenging. The study’s objective was to evaluate the efficacy of a combined endoscopic transethmoid and transconjunctival approach in patients without functional vision.DesignA retrospective, noncomparative case series.MethodsRetrospective data were collected from all patients who had undergone tumor resection using this approach at the authors’ institution between 2015 and 2021. Preoperative assessments included magnetic resonance imaging and ophthalmological examinations, and re-assessments were conducted three months after surgery and regularly during the follow-up period.ResultsSeventeen patients, mean age 35 ± 19.0 years, were enrolled. Of these, 64.7% presented with visual acuity (VA) of light perception or no light perception. Gross total resection was realized in all patients. The average decline in exophthalmos was 3.63 ± 1.93 mm. Tumor histopathological analysis identified 12 optic nerve sheath meningiomas and 5 optic gliomas. The mean follow-up time was 30 months during which there was no local recurrence in any of the patients.ConclusionsThe combined endoscopic transethmoid and transconjunctival approach offers an additional choice for accessing optic nerve tumors. The procedure is both safe and effective and provides an alternative transcranial route to the orbit.
Harnessing genetic resistance to rusts in wheat and integrated rust management methods to develop more durable resistant cultivars
Authors: Mapuranga Johannes , Zhang Na , Zhang Lirong , Liu Wenze , Chang Jiaying , Yang Wenxiang 
Published: October 2022

Wheat is one of the most important staple foods on earth. Leaf rust, stem rust and stripe rust, caused by Puccini triticina, Puccinia f. sp. graminis and Puccinia f. sp. striiformis, respectively, continue to threaten wheat production worldwide. Utilization of resistant cultivars is the most effective and chemical-free strategy to control rust diseases. Convectional and molecular biology techniques identified more than 200 resistance genes and their associated markers from common wheat and wheat wild relatives, which can be used by breeders in resistance breeding programmes. However, there is continuous emergence of new races of rust pathogens with novel degrees of virulence, thus rendering wheat resistance genes ineffective. An integration of genomic selection, genome editing, molecular breeding and marker-assisted selection, and phenotypic evaluations is required in developing high quality wheat varieties with resistance to multiple pathogens. Although host genotype resistance and application of fungicides are the most generally utilized approaches for controlling wheat rusts, effective agronomic methods are required to reduce disease management costs and increase wheat production sustainability. This review gives a critical overview of the current knowledge of rust resistance, particularly race-specific and non-race specific resistance, the role of pathogenesis-related proteins, non-coding RNAs, and transcription factors in rust resistance, and the molecular basis of interactions between wheat and rust pathogens. It will also discuss the new advances on how integrated rust management methods can assist in developing more durable resistant cultivars in these pathosystems.
Do COVID-19 CT features vary between patients from within and outside mainland China? Findings from a meta-analysis
Authors: Hou Nianzong , Wang Lin , Li Mingzhe , Xie Bing , He Lu , Guo Mingyu , Liu Shuo , Wang Meiyu , Zhang Rumin , Wang Kai 
Published: October 2022

BackgroundChest computerized tomography (CT) plays an important role in detecting patients with suspected coronavirus disease 2019 (COVID-19), however, there are no systematic summaries on whether the chest CT findings of patients within mainland China are applicable to those found in patients outside.MethodsRelevant studies were retrieved comprehensively by searching PubMed, Embase, and Cochrane Library databases before 15 April 2022. Quality assessment of diagnostic accuracy studies (QUADAS) was used to evaluate the quality of the included studies, which were divided into two groups according to whether they were in mainland China or outside. Data on diagnostic performance, unilateral or bilateral lung involvement, and typical chest CT imaging appearances were extracted, and then, meta-analyses were performed with R software to compare the CT features of COVID-19 pneumonia between patients from within and outside mainland China.ResultsOf the 8,258 studies screened, 19 studies with 3,400 patients in mainland China and 14 studies with 554 outside mainland China were included. Overall, the risk of quality assessment and publication bias was low. The diagnostic value of chest CT is similar between patients from within and outside mainland China (93, 91%). The pooled incidence of unilateral lung involvement (15, 7%), the crazy-paving sign (31, 21%), mixed ground-glass opacities (GGO) and consolidations (51, 35%), air bronchogram (44, 25%), vascular engorgement (59, 33%), bronchial wall thickening (19, 12%), and septal thickening (39, 26%) in patients from mainland China were significantly higher than those from outside; however, the incidence rates of bilateral lung involvement (75, 84%), GGO (78, 87%), consolidations (45, 58%), nodules (12, 17%), and pleural effusion (9, 15%) were significantly lower.ConclusionConsidering that the chest CT features of patients in mainland China may not reflect those of the patients abroad, radiologists and clinicians should be familiar with various CT presentations suggestive of COVID-19 in different regions.