bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transparent soil model test and numerical study on the effect of adjacent spring on the stability of tunnel face in composite strata
Authors: Ma Shaokun , Wei Hongye , Duan Zhibo , Liu Ying , Huang Zhen , He Benfu , Zhou Zhang 
Published: December 2022

Abstract
To study the instability and failure mechanism of tunnel face in composite stratum and the evolution law of supporting pressure in the areas with spring, this paper used two different types of transparent soil and a self-designed 3D model test system. Six large transparent soil model tests were carried out by considering different confined water heads of spring and tunnel burial depth. The optical laser and high-speed camera were controlled to move on a high-precision linear platform. CT scanning was performed to obtain the failure model under different conditions. The finite element method considering a two-way fluid-structure coupling was used to validate the model test. The research results indicate under spring, the support pressure curves can be divided into three stages: rapid decline, rebound-rise, and constant. There is no rebound-rise stage under the condition of no spring. With increased confined water heads or reduced tunnel burial depth, limit support pressure shows an increasing trend. 2D and 3D damage models for different working conditions were obtained by PIV technology and 3D reconstruction technology. If there is a spring, the maximum displacement moves to the top of the tunnel with the increase of water head and the failure mode is a combination of “silo shape” and “inverted prism”. When there is no spring, the maximum displacement appears at the interface of the soil layer, and the failure mode is a combination of “silo shape” and “wedge shape”. The presence or absence of springs and the change of the confined water head have no significant effect on the height of the loosening area. When the tunnel burial depth ratio from 0.5 to 2.0, the height of the loose area increases from 0.17D to 0.83D, and the soil arch area develops outward.
Socio-ecological impact of monogenetic volcanism
Authors: Revelles Jordi , Marti Joan , Burjachs Francesc , Finsinger Walter , Iriarte Eneko , Mesquita-Joanes Francesc , Pla-Rabes Sergi , Planagumà Llorenç , Rodrigo Maria A. , Alcalde Gabriel , Saña Maria 
Published: December 2022

Abstract
Although volcanism may and has caused major impacts during Earth evolution, including climate change and mass extinctions, the impact of monogenetic volcanism is usually considered as limited or underestimated in volcanological research. During the Late Glacial- Early Holocene (14 − 8.6 kyr cal BP) transition, intense monogenetic volcanic activity occurred in the La Garrotxa Volcanic Field (GVF, Girona, NE Iberia). This work provides for the first time an interdisciplinary approach to the socio-ecological impact of monogenetic volcanism, providing clear effects of environmental change on geomorphology, vegetation, aquatic organisms and humans. These analyses enabled us to identify eruptions not previously reported in theGVFduring the Late Glacial-Early Holocene, constrain their volcanic stratigraphy and age, and reconstruct the major palaeoenvironmental changes caused by the eruptions in terms of fire episodes and subsequent disturbance on vegetation, hydrology and limnological conditions. The archaeological record in the region shows that the last hunter-gatherer communities were resilient against volcanic activity at an extra-local scale, suggesting that their flexible nomadic patterns and foraging economies were an efficient source of risk management against the volcanic eruptions and their ecological impacts.
M1 transcranial Direct Current Stimulation augments laparoscopic surgical skill acquisition
Authors: Galvin Daniel , Toth Adam , O'Reilly Barry , O'Sullivan Ray , Campbell Mark 
Published: December 2022

Abstract
The acquisition of basic surgical skills is a key component of medical education and trainees in laparoscopic surgery typically begin developing their skills using simulation box trainers. However, despite the advantages of simulation surgical training, access can be difficult for many trainees. One technique that has shown promise to enhance the deliberate practice of motor skills is transcranial electric stimulation (tES). The purpose of this study was to assess the impact of transcranial direct current stimulation (tDCS) on training induced improvements and retention of traditional time and kinematic based laparoscopic surgical skill metrics. Forty-nine participants were randomly allocated to a neurostimulation or sham group and completed 5 training sessions of a bead transfer and threading laparoscopic task. Participants in both the sham and stimulation groups significantly improved their time and kinematic performance on both tasks following training. Although we did find that participants who received M1 tDCS saw greater performance benefits in response to training on a bead transfer task compared to those receiving sham stimulation no effect of neurostimulation was found for the threading task. This finding raises new questions regarding the effect that motor task complexity has on the efficacy of neurostimulation to augment training induced improvement and contributes to a growing body of research investigating the effects of neurostimulation on the sensory-motor performance of laparoscopic surgical skill.
Offloading effects of a removable cast walker with and without modification for diabetes-related foot ulceration: a plantar pressure study
Authors: Withers Rebekah V , Perrin Byron M , Landorf Karl B , Raspovic Anita 
Published: December 2022

Abstract
Background: Removable cast walkers (RCWs), with or without modifications, are used to offload diabetes-related foot ulcers (DRFUs), however there is limited data relating to their offloading effects. This study aimed to quantify plantar pressure reductions with an RCW with and without modification for DRFUs.
Methods: This within-participant, repeated measures study included 16 participants with plantar neuropathic DRFUs. Walking peak plantar pressures at DRFU sites were measured for four conditions: post-operative boot (control condition), RCW alone, RCW with 20 mm of felt adhered to an orthosis, and RCW with 20 mm of felt adhered to the foot.
Results: Compared to the control condition, the greatest amount of peak plantar pressure reduction occurred with the RCW with felt adhered to the foot (83.1% reduction, p < .001). The RCW with felt adhered to the foot also offered greater peak plantar pressure reduction than the RCW alone (51.3%, p = .021) and the RCW with felt adhered to an orthosis (31.4%, p= .009).
Conclusion: The largest offloading effect recorded was with the RCW with felt adhered to the foot. High-quality randomised trials are now needed to evaluate the effectiveness of this device for healing DRFUs.
Nonadiabatic to Adiabatic Transition of Electron Transfer in Colloidal Quantum Dot Molecules
Authors: Hou Bokang , Thoss Michael , Banin Uri , Rabani Eran 
Published: December 2022

Abstract
Electron transfer is an important and fundamental process in chemistry, biology and physics, and has received significant attention in recent years. Perhaps one of the most intriguing questions concerns with the realization of the transitions between nonadiabatic and adiabatic regimes of electron transfer, as the coupling (hybridization) energy, J, between the donor and acceptor is varied. Here, using colloidal quantum dot molecules, a new class of coupled quantum dot dimers, we computationally demonstrate how the hybridization energy between the donor and acceptor quantum dots can be tuned by simply changing the neck dimensions and/or the quantum dot size. This provides a handle to tune the electron transfer from the nonadiabatic over-damped Marcus regime to the coherent adiabatic regime in a single system, without changing the reorganization energy, λ, or the typical phonon frequency, ωc. We develop an atomistic model to account for several donor and acceptor states and how they couple to the lattice vibrations, and utilize the Ehrenfest mean-field mixed quantum-classical method to describe the charge transfer dynamics as the nonadiabatic parameter, γ, is varied. We find that charge transfer rates increase by several orders of magnitude as the system is driven to the coherent, adiabatic limit, even at elevated temperatures, and delineate the inter-dot and torsional acoustic modes that couple most strongly to the charge transfer reaction coordinate.
An iterative generalized quasi-boundary value regularization method for the backward problem of time fractional diffusion-wave equation in a cylinder
Authors: Shi Chengxin , Cheng Hao 
Published: December 2022

Abstract
In this paper, we consider the backward problem for a time fractional diffusion-wave equation in a cylinder. The ill-posedness and a conditional stability of the inverse problem are proved. Based on the generalized quasi-boundary value regularization method, we propose an iterative generalized quasi-boundary value regularization method to deal with the inverse problem, and this iterative method has a higher convergence rate. The convergence rates of the regularized solutions under an a priori regularization parameter choice rule and an a posteriori regularization parameter choice rule are obtained. Numerical examples illustrate the effectiveness and stability of our proposed method.
Advantages of nighttime lighting for growth of juvenile Pacific bluefin tuna Thunnus orientalis
Authors: Honryo Tomoki , Sawada Yoshifumi , Ishibashi Yasunori 
Published: December 2022

Abstract
During the fingerling production process of Pacific bluefin tuna (PBF), Thunnus orientalis, heavy mortality can occur immediately after the transportation of juveniles from nursery tanks to sea cages and the nighttime lighting moderates this mortality. It has been confirmed that various wild live prey gathered under nighttime lighting in practical sea cage culture of PBF. We validated the effectiveness of nighttime lighting to combat mortality by examined its effects on PBF growth and survival. To prove this, the present study was performed in land-based tanks, such that changes in environmental conditions did not affect the experiment. We investigated whether the growth and viability of PBF juveniles could be improved by promoting feeding live preys under nighttime lighting (treatment; Nigh-Feed, n = 4) and compared them with negative control group which were not fed during night (Control, n = 4). Results showed that growth was significantly improved under the Night-Feed group in which 69–78% of juveniles showed evidence of having fed during the night. However, the rate of survival was statistically similar between the group. It is anticipated that nighttime lighting plays an important role to gather various live preys during night and PBF juveniles consumed these feed items in sea cage. This could partially serve as a countermeasure against heavy mortality occurs in sea cage by promoting juvenile growth.
Multiclass Classification of Thyroid gland data employing Linear Discriminant Analysis
Authors: Murali M. 
Published: December 2022

Abstract
With the advent of internet, complex data is tremendously increased. It is essential to analyze the data. Multiclass classification, has been an important problem for a long time in supervised learning. In multiclass classification the independent variables are used to map it with k number of classes. Linear discriminant analysis is a supervised learning method to classify k number of classes. We consider applying Fisher’s Linear Discriminant Analysis(LDA) procedure to the multiclass classification. In this work, we used thyroid gland dataset to classify state of the thyroid gland. The experiments were conducted to evaluate the Fisher’s LDA method using four metrics: precision, recall , F1-score and accuracy. As the results indicated by the experiments, the Fisher’s LDA shown the best classification accuracy. Further, the Fisher’s LDA method is compared with multiclass linear regression and multiclass support vector machine.
The Vaginal Microbiota in Early Pregnancy Identifies a Subset of Women at Risk for Early Preterm Prelabor Rupture of Membranes and Preterm Birth
Authors: Romero Roberto , Tarca Adi , Gomez-Lopez Nardhy , Winters Andrew , Panzer Jonathan , Lin Huang , Gudicha Dereje , Galaz Jose , Farias-Jofre Marcelo , Kracht David , Chaiworapongsa Tinnakorn , Jung Eunjung , Gotsch Francesca , Suksai Manaphat , Berry Stanley , Ravel Jacques , Peddada Shyamal , Theis Kevin 
Published: December 2022

AbstractSpontaneous preterm birth (sPTB) can occur when vaginal bacteria gain access to the amniotic cavity. Thus, the predictive value of the vaginal microbiota for sPTB has been investigated, yet results have been inconclusive. Here, we report the largest study of the vaginal microbiota using longitudinal sampling of 257 cases and 514 controls (2,976 samples). Associations between the microbiota and sPTB were limited to cases of early (delivery <34 weeks) preterm prelabor rupture of membranes (PPROM). Starting with early gestation, microbial diversity was higher in early PPROM cases than controls, as were the relative abundances of Anaerococcus, Mobiluncus, Prevotella, and Sneathia. Random forest models based on data collected before 28 weeks predicted early PPROM [AUC=0.62(0.51−0.73)], while data collected by 24 weeks predicted PPROM with delivery <30 weeks [AUC=0.68(0.53-0.84)]. Therefore, monitoring of the vaginal microbiota profile may have clinical utility to identify a subset of women who will deliver a preterm neonate.
Suppression of MyD88 disturbs gut microbiota and activates NLRs pathway hence fails to ameliorate DSS-induced colitis
Authors: Chen Yu , Li Jun-hua , Ye Zheng-hao , Chen Li-ping , Xu Jia-xin , Han Jian , Xie Lin , Xing Shuai , Liao Jia-zhi , Seidler Ursula , Tian De-an , Xiao Fang 
Published: December 2022

Abstract
Background: The interaction between gut microbiota and innate immunity plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Myeloid differentiation factor 88 (MyD88) is the core adaptor for Toll-like receptors (TLRs) defending against microbial invasion and initiating downstream immune response during microbiota-host interaction. However, the role of MyD88 in the pathogenesis of IBD is controversial. This study aims to investigate the impact of MyD88 on intestinal inflammation and the underlying mechanism.
Methods: MyD88 inhibitor (TJ-M2010-5, TJ5) were used to investigate the effect of MyD88 suppression on acute DSS-induced colitis. Disease activity index, colon length, histological score and inflammatory cytokines were examined to evaluate the colitis severity. The RNA transcriptome analysis and 16S rDNA sequencing were used to detect the potential mechanism.
Results: In the acute DSS-colitis model, the colitis severity was not alleviated in TJ5-treated mice, though the significantly lower of MyD88 expression and NF-κB activation were exhibited compared with control mice. Meanwhile, the 16S rDNA sequencing and RNA transcriptome analysis showed a higher abundance of intestinal Proteobacteria and an up-regulation of NOD-like receptors (NLRs) signaling pathway in colitis mice after MyD88 suppression. Further blockade of the NLR signaling pathway or elimination of gut microbiota with broad-spectrum antibiotics in DSS-induced colitis mice treated with TJ5 ameliorated the disease severity that was not improved by solely MyD88 inhibition. The downregulated NLR signaling pathway after broad-spectrum antibiotics treatment suggested that the MyD88 suppressionassociated dysbiosis may stimulate intestinal inflammation via NLR signaling pathway.
Conclusion: Our study revealed that the suppression of MyD88 may be associated with unfavorable changes in the gut microbiota composition and lead to immune activation mediated by NLRs, which may play an important role in modulating intestinal inflammation.
Material Analysis for Restoration Application: A case study of The World's First University Mor Yakup Church
Authors: Karataş Lale , Alptekin Aydın , Yakar Murat 
Published: December 2022

Abstract
In historical stone structures, material deterioration occurs over time due to climate-related reasons. In order to perform the correct interventions to these material deteriorations in the building, original material properties should be determined and restoration applications should be carried out in accordance with these properties. In this study, it was aimed to examine the material properties and problems of the Mor Yakup Church, in the Nusaybin District of Mardin Province, in order to create a laboratory guideline that reveals the material analysis to be used in the restorations to be made at the regional scale of Mardin. Although many studies have been carried out on the structure, up-to-date information and data on the chemical-physical decomposition processes that have occurred on the material over the years are lacking. In order to fill this gap and provide basic information for the proper preservation of the structure, the Mor Yakup Church was analyzed. This structure is important in that it is the first university of education in the world that has survived to the present day. In this study, field studies and laboratory studies were carried out to determine the textural, physical, chemical, mineralogical and mechanical properties of the material used in the building, and the changes it has undergone over the years. The weathering pattern, forms and profiles show that the limestone deteriorates due to the cement-containing mortars used in the building and environmental effects (especially from the exhaust gas effect). It has been determined that nitrate salt has a role in the intense black layering, which can be observed visually, especially on the stone surfaces.
Extended ligation of hepatic vein may obtain similar effect to live venous deprivation in rat model
Authors: He Xiaoqin , Zhang Yuefeng , Zhang Gaoshuo , Ma Peng , Xiong Liangkun , Wang Wei , Xu Yangtao , Shen Yang , Yu Kaihuan , Wang Weixing 
Published: December 2022

Abstract
Aims: To verify the hypothesis that the hepatic vein ligation (HVL) alone may produce similar results to the live venous deprivation (LVD or HVL/PVL).
Methods: Rats were assigned to 5 groups, the control group; R group: the right median hepatic vein (RMHV) was ligated; M group: the middle median hepatic vein (MMHV) was ligated, RM group: both the RMHV and MMHV were ligated; LVD group: both the right median portal vein (RMPV) and the RMHV were ligated. Liver hypertrophy effect and liver enzymes were determined. The methylene blue staining and retrograde pressurized perfusion assay were performed to observe the hemodynamic changes.
Results: The RM and LVD groups exhibited similar significant hypertrophy in the future liver remnants when compared to the control group, and almost no additional hypertrophy effect were observed in the R and M group. A remarkable elevation in serum transaminase levels in both those groups. The methylene blue staining indicated that there are pressured-dependent collaterals between the contigeous drainage areas, the R+MMHVL procedures block the outflow of RML.
Conclusion: The extended ligation of hepatic vein (R+MMHVL) obtained the similar hypertrophy effect and hepatic damage to the LVD in rat model, and the intrahepatic venovenous collaterals play key roles.
OsCCRL1 is essential for phenylpropanoid metabolism in rice anthers
Authors: Zhang Lisha , Zheng Lintao , Wu Jinwen , Liu Yang , Liu Weichi , He Guanghua , Wang Nan 
Published: December 2022

Abstract
Phenylpropanoid metabolism and timely tapetal degradation are essential for male gametophyte development, but the underlying mechanisms in rice are unclear. In the current study, to investigate this process, we identified and analyzed the male-sterile mutant, osccrl1 (cinnamoyl coA reductase-like 1), which exhibits delayed tapetal programmed cell death and defective mature pollen. Map-based cloning, genetic complementation, and gene knockout revealed that OsCCRL1 corresponds to the gene LOC_Os09g32020.2, encoding a SDR (short-chain dehydrogenase/reductase) family enzyme. OsCCRL1 was preferentially expressed in the tapetal cells and microspores, and localized to the nucleus and cytoplasm in both rice protoplasts and Nicotiana benthamiana leaves. The osccrl1 mutant exhibited reduced CCRs enzyme activity, less lignin accumulation, delayed tapetum degradation signal, and disrupted phenylpropanoid metabolism. Furthermore, an R2R3 MYB transcription factor OsMYB103/OsMYB80/OsMS188, involved in tapetum and pollen development, regulates the expression of OsCCRL1. Finally, the osmyb103 osccrl1 double mutants, exhibited the same phenotype as the osmyb103 single mutant, further indicating that OsMYB103/OsMYB80/OsMS188 functions upstream of OsCCRL1. These findings help clarify the role of phenylpropanoid metabolism in rice male sterility and the regulatory network underlying the tapetum degradation in rice.
Trichoscopic, oral and periungual fold findings as activity and damage markers in Dermatomyositis patients and their correlation with myositis antibodies
Authors: Salgueiro Catalina , Poblete María José , Robles-Silva Christian , Abarzúa Álvaro , Vera-Kellet Cristián 
Published: December 2022

Abstract
There is little clarity about the clinical manifestations of dermatomyositis (DM) in the periungual folds, scalp, and oral cavity and their association with disease activity and damage. The objective of this study was to compare the prevalence of trichoscopic, oral, and periungual changes between DM and healthy patients and assess their possible association with disease activity and damage. We conducted an observational, transversal, and analytical study between 2020 and 2021. Forty DM patients were matched by sex and age with 40 healthy individuals. On the same day, all patients had a clinical evaluation of the hands, periungual folds, scalp, and oral cavity. Photographs of these areas and peripheral venous blood tests, including myositis-associated (MAAs) and myositis-specific antibodies (MSAs), were taken. Two dermatologists blinded to their diagnosis, damage, and activity levels registered the lesions. The disease activity and damage were evaluated using the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI). The presence of mechanic’s hands, Gottron’s sign, and Gottron’s papules in hands; capillary dilation, capillary tortuosity, cuticular hemorrhage, avascular areas, and cuticular hyperkeratosis in periungual folds; thick tortuous capillaries in scalp; gingival telangiectasias in the oral cavity; and positive MSAs associated with severe cutaneous involvement in DM patients (Anti-TIF1g, Anti-MDA5, Anti-SAE1/2) were associated with a higher CDASI activity score. The presence of MSAs associated with intense muscle involvement in DM patients (Anti-Mi2a, Anti-Mi2b, Anti-NPX2, and Anti-SAE1/2) was related to a lower CDASI activity score. Gottron’s sign and Gottron’s papules in hands; capillary dilation, capillary tortuosity, cuticular hemorrhage, avascular areas, and cuticular hyperkeratosis in periungual folds; basal erythema in scalp; and gingival telangiectasias in the oral cavity were associated with a higher CDASI damage score. There are trichoscopic, oral and periungual fold findings, and some myositis-specific antibodies that correlate with disease activity and damage in DM patients.