bluuebunny/crossref_metadata_2025_split huggingface dataset:
The aryl hydrocarbon receptor directs the differentiation of murine progenitor blastomeres
Authors: Ko Chia-I. , Biesiada Jacek , Zablon Hesbon A. , Zhang Xiang , Medvedovic Mario , Puga Alvaro 
Published: August 2022

AbstractKey regulatory decisions during cleavage divisions in mammalian embryogenesis determine the fate of preimplantation embryonic cells. Single-cell RNA sequencing of early-stage—2-cell, 4-cell, and 8-cell—blastomeres show that the aryl hydrocarbon receptor (AHR), traditionally considered as an environmental sensor, directs blastomere differentiation. Disruption of AHR functions inAhrknockout embryos or in embryos from dams exposed to dioxin, the prototypic xenobiotic AHR agonist, significantly impairs blastocyst formation, causing repression and loss of transcriptional heterogeneity of OCT4 and CDX2 and incidence of nonspecific downregulation of pluripotency. Trajectory—the path of differentiation—and gene variability analyses further confirm that deregulation of OCT4 functions and changes of transcriptional heterogeneity resulting from disruption of AHR functions restrict the emergence of differentiating blastomeres in 4-cell embryos. It appears that AHR directs the differentiation of progenitor blastomeres and that disruption of preimplantation AHR functions may significantly perturb embryogenesis leading to long-lasting conditions at the heart of disease in offspring’s adulthood.
Molecularly imprinted copolymer/reduced graphene oxide for the electrochemical detection of herbicide propachlor
Authors: Elshafey Reda , Radi Abd-Elgawad 
Published: August 2022

AbstractThe toxicity of propachlor (PROP) with its chloroacetanilide members is reported. Rapid and sensitive detection of PROP is critical for ecotoxicity evaluation and the removal process. A novel voltammetric sensor is developed based on imprinted poly (o-phenylene diamine-co-pyrrole) (o-PD-co-Py) and electrochemically reduced graphene oxide (ERGO) to detect PROP at a trace level. The use of ERGO provides a high density of imprinted cavities for better sensitivity. The imprinted layer of poly (o-PD-co-Py) improves the selectivity of the sensor. The electrode modification was characterized by scanning electron microscopy and electrochemical approaches. The working parameters of the sensor were investigated and optimized. The redox behavior of an external probe of [Fe(CN)6]3−/4− was recorded as the sensor signal for PROP selective binding. The proposed sensor presented wide linear responses to logarithmic PROP concentrations from 0.1 pM to 0.1 µM with a LOD of 0.08 pM. The sensor’s selectivity against some interference was demonstrated. This sensor was applied successfully to detect PROP in spiked water (lake and tap), red tea, and soil samples with good recoveries and reasonable RSD % values.
Graphical abstract
The pragmatics and syntax of pronoun preposing
Authors: Lindahl Filippa , Engdahl Elisabet 
Published: August 2022

AbstractPreposed pronouns have a dual role of both connecting the utterance to the context and serving as its starting point. While central to understanding restrictions on syntactic movement to the left periphery, this type of fronting has often been overlooked. We provide an analysis of the pragmatics and syntax of Swedish pronoun preposing based on a study of spontaneously produced spoken language from theNordic Dialect Corpus. We find that there is a strong preference for preposing pronouns that function as switch topics and that it is also possible to prepose continued topics, but in neither case is the preposing obligatory. We argue that these sentence-external relations of the topic are not encoded in the syntax of the left periphery in Swedish, but reflect pragmatic strategies for discourse progression. The types of topic (switch or continued) are furthermore shown not to correlate with the prosodic realization of the pronoun. A key feature of our analysis is that we distinguish the sentence-external function of the preposed phrase from the sentence-internal function of providing the aboutness topic for the utterance. We adopt an analysis of the left periphery proposed by Holmberg, where FinP acts as a bottleneck, and there is only one, syncretic, Force-Topic head above Fin. The fact that we only see evidence for one topic position to the left of the subject in Swedish sets this language apart from German and Italian as they are analyzed by e.g. Frey and Frascarelli and Hinterhölzl, as does the fact that A$$'$$′-movement of pronouns in Swedish does not imply any particular prosodic marking.
Impact energy and the risk of injury to motorcar occupants in the front-to-side vehicle collision
Authors: Prochowski Leon , Ziubiński Mateusz , Dziewiecki Krzysztof , Szwajkowski Patryk 
Published: August 2022

AbstractThe effects of a road accident where one vehicle hits its front on the side of another one are explored. In such cases, the impacted vehicle’s side is usually significantly deformed, which causes a risk of serious injury to vehicle occupants. An analysis of the front-to-side collision covers many nonlinear and highly complex processes, especially when it is based on the collision energy balance. For the analysis, a model of a front-to-side motorcar collision and a dummy representing the impacted vehicle’s driver was prepared. The model simulations carried out were supplemented with important experimental test results. The model validation and the drawing of conclusions from research results were based on crash test results. The shares of major components in the front-to-side collision energy balance were determined. The impact energy has been proposed as an alternative predicate of the road accident effects; as a measure of the effects, the risk of injury to vehicle occupant’s head and torso is considered. The model simulations were found to be in good conformity with experimental test results. The research results enabled determining the relation between the side impact energy and the risk of dummy’s head and torso injuries according to the Abbreviated Injury Scale. The relation obtained was approximated using the logit model. This relation helps to reconstruct road accidents and to improve the car side’s passive safety systems. A discussion of the results obtained has shown good consistence between the results of this work and other comparable research results.
Building local capacity for managing environmental risk: a transferable framework for participatory, place-based, narrative-science knowledge exchange
Authors: McEwen Lindsey , Roberts Liz , Holmes Andrew , Blake James , Liguori Antonia , Taylor Tim 
Published: August 2022

AbstractThis paper evaluates a unique, transdisciplinary participatory research and knowledge exchange methodology developed in the Drought Risk and You (DRY) project and offers it as a transferable framework for others engaging stakeholders and systemic connections with environmental risk. Drought in the UK is a complex, diffuse and hidden risk, involving multiple stakeholders and systemic connections across diverse sectors. Historically, drought risk management has been underpinned by specialist science and technology implemented by statutory stakeholders. This paper critically evaluates the social learning from a longitudinal research process that involved co-working with seven river catchment-based, multi-stakeholder groups. The DRY project was a creative experiment in bringing drought science and stories into the same space, aiming to reveal different knowledges—specialist science, practical sector-level insight, and local knowledge—as a new evidence base to support better decision-making in UK drought risk management. An evaluative multi-method research methodology was overlaid on this process, using surveys, within meeting reflective evaluations, and summative semi-structured narrative interviews. This paper reflects on participant experiences of the ‘open’ scientific modelling development, ‘storying’ approaches, and their iterative interaction. It outlines the enablers, inhibitors and required support for this engagement process, which aimed to facilitate integration of different forms of knowledge as evidence, with social and sustainability learning among diverse stakeholders at its core. The process offered opportunity for valuable experiential learning as researchers of the nuanced impacts of intersecting factors on participatory place-based methods. It showed that similar approaches to science-narrative dialogic processes can play out locally to integrate aspects of social and sustainability learning in different ways. This sustainability learning provided a valuable platform for creative multi-stakeholder scenario-ing possible drought futures for increased local climate resilience. It then proposes a transferable research framework that promotes participatory, place-based, narrative-science knowledge exchange for building local capital for managing systemic environmental risk.
Jurassic-Lower Cretaceous petroleum system of Faghur Basin, North Western Desert, Egypt
Authors: El Sherief Mai A. , Elbastawesy Mohamed A. , Abdeldayem Abdelaziz L. , Mohamed Shadia A. 
Published: August 2022

AbstractDifferent parts of the Lower Cretaceous Alam El Bueib (AEB) and the Jurassic Khatatba source and reservoir rock units in the Faghur basin, like in other basins in the north Western Desert, act as hydrocarbon sources and reservoirs. In the present study, well-log data from five wells in Phiops field and geochemical data from the Neith S-2X well from the neighbor Neith field together with reflection 2D seismic data of thirty (30) lines have been utilized to evaluate the Jurassic-Lower Cretaceous petroleum system in the Faghur basin and to give evidence for future hydrocarbon exploration and development in the study area. Source rock evaluation shows that several units from both Alam El Bueib and the Jurassic Khatatba shale source rocks represent good source rocks. Total organic carbon (TOC) values of the studied units of Alam El Bueib shale source rocks range from 0.27 to 6.39 wt.% that reflect fair to very good source rock, while Toc value for the Alam El Bueib-6 shale source rock is 2.52 wt.% that indicates a very good source rock. These units are characterized by type (III) kerogen, reflecting their ability to produce gas with minor oil. On the other hand, the characterization of the Khatatba shale source rocks indicates a very good to fair organic richness and a type (III) kerogen with an input of type (II) as well, which appears their ability to generate gas with minor oil. Most of Alam El Bueib and Khatatba shale source rocks are found to be in the mature stage. Petrophysical evaluation indicates four definite reservoir units from the Alam El Bueib reservoirs (Alam El Bueib-3D, Alam El Bueib-3E, Alam El Bueib-3G, Alam El Bueib-6) and the Khatatba reservoir. Values for the net reservoir, hydrocarbon saturation, and water saturation indicate that these units represent very promising reservoirs in the studied Phiops field in Faghur basin. Local intra-formational shale intervals most probably seal these reservoirs in the AEB and carbonate interval of the Masajid Formation in the Khatatba Formation. Moreover, analysis and interpretation of the 2D seismic lines showed that both structural and stratigraphic traps dominate. Integration of geochemical, petrophysical, and seismic results, in light of available geological information, indicates a complete Mesozoic petroleum system in the Faghur basin.
Prodigiosin-Functionalized Probiotic Ghosts as a Bioinspired Combination Against Colorectal Cancer Cells
Authors: Saleh Nessrin , Mahmoud Hoda E. , Eltaher Hoda , Helmy Maged , El-Khordagui Labiba , Hussein Ahmed A. 
Published: August 2022

AbstractLactobacillus acidophilus ghosts (LAGs) with the unique safety of a probiotic, inherent tropism for colon cells, and multiple bioactivities offer promise as drug carriers for colon targeting. Our objective was to evaluate LAGs functionalized with prodigiosin (PG), apoptotic secondary bacterial metabolite, as a bioinspired formulation against colorectal cancer (CRC). LAGs were prepared by a chemical method and highly purified by density gradient centrifugation. LAGs were characterized by microscopic and staining techniques as relatively small-sized uniform vesicles (≈1.6 µm), nearly devoid of cytoplasmic and genetic materials and having a negatively charged intact envelope. PG was highly bound to LAGs envelope, generating a physiologically stable bioactive entity (PG-LAGs), as verified by multiple microscopic techniques and lack of PG release under physiological conditions. PG-LAGs were active against HCT116 CRC cells at both the cellular and molecular levels. Cell viability data highlighted the cytotoxicity of PG and LAGs and LAGs-induced enhancement of PG selectivity for HCT116 cells, anticipating dose reduction for PG and LAGs. Molecularly, expression of the apoptotic caspase 3 and P53 biomarkers in HCT116 intracellular proteins was significantly upregulated while that of the anti-apoptotic Bcl-2 (B-cell lymphoma 2) was downregulated by PG-LAGs relative to PG and 5-fluorouracil. PG-LAGs provide a novel bacteria-based combination for anticancer biomedicine.
Graphical abstract
Comparative effect of the three talc deposits in detoxification of Cr(VI) from wastewater
Authors: Elnazer A. A. , Azer M. K. , Mohamed Y. M. A. , El Nazer H. A. 
Published: August 2022

AbstractEnvironmental application of three different talc deposits toward the removal of hexavalent chromium ions Cr(VI) from aqueous solution as simulated polluted water was investigated. Three talc samples (T1, T2 and T3) were used from Wadi Atshan area, Eastern desert, Egypt. The affecting parameters, such as pH, contact time, solution pH and the dosage, were studied during the progress of the adsorption process of chromium (IV). The results showed that a contact time of 65 min for T3, 80 min for T2, 85 min for T1 under optimum condition at pH 7 at 25 °C. The adsorption capacity for the removal of Cr(VI) using the three samples T1, T2 and T3 was evaluated to be 78%, 86% and 97%, respectively, under optimized conditions utilizing 1.0 g/L of the adsorbent. Characterization of the three talc samples was performed using XRF, XRD and FTIR analyses in order to assess the physicochemical properties of the adsorbents. This approach provided new class of adsorbent as highly efficient materials for Cr(VI) removal based on talc deposits which possess some privileges such as availability of the natural resources that makes the process to be low cost and simple.
An eigenfunction expansion formula for one-dimensional two-state quantum walks
Authors: Tate Tatsuya 
Published: August 2022

AbstractThe purpose of this paper is to give a direct proof of an eigenfunction expansion formula for one-dimensional two-state quantum walks, which is an analog of that for Sturm–Liouville operators due to Weyl, Stone, Titchmarsh, and Kodaira. In the context of the theory of CMV matrices, it had been already established by Gesztesy–Zinchenko. Our approach is restricted to the class of quantum walks mentioned above, whereas it is direct and it gives some important properties of Green functions. The properties given here enable us to give a concrete formula for a positive-matrix-valued measure, which gives directly the spectral measure, in a simplest case of the so-called two-phase model.
Construction of Fuzzy Linguistic Approximate Concept Lattice in an Incomplete Fuzzy Linguistic Formal Context
Authors: Yang Dongqiang , Yang Xinran , Jia Hui , Xu Lixian , Guo Jin 
Published: August 2022

AbstractUncertainty research is one of the critical problems in artificial intelligence. In an uncertain environment, a large quantity of information is expressed in linguistic values. Aiming at the missing linguistic-valued information, we first propose incomplete fuzzy linguistic formal context and then discuss the fuzzy linguistic approximate concept. Our proposal can describe the attributes of objects from two aspects simultaneously. One is an object's essential attributes, and another includes the essential and possible attributes. As a result, more object-related information can be obtained to reduce information loss effectively. We design a similarity metric for correcting the errors caused by the initial complement operation. We then construct a corresponding fuzzy linguistic approximate concept lattice for the task of approximate information retrieval. Finally, we illustrate the applicability and feasibility of the proposed approach with concrete examples, which clearly show that our approach can better deal with the linguistic-valued information in an uncertain environment.
Genomic Variations in the Tea Leafhopper Reveal the Basis of Its Adaptive Evolution
Authors: Zhao Qian , Shi Longqing , He Weiyi , Li Jinyu , You Shijun , Chen Shuai , Lin Jing , Wang Yibin , Zhang Liwen , Yang Guang , Vasseur Liette , You Minsheng 
Published: August 2022

Abstract
Tea green leafhopper (TGL), Empoasca onukii, is of biological and economic interest. Despite numerous studies, the mechanisms underlying its adaptation and evolution remain enigmatic. Here, we use previously untapped genome and population genetics approaches to examine how the pest adapted to different environmental variables and thus has expanded geographically. We complete a chromosome-level assembly and annotation of the E. onukii genome, showing notable expansions of gene families associated with adaptation to chemoreception and detoxification. Genomic signals indicating balancing selection highlight metabolic pathways involved in adaptation to a wide range of tea varieties grown across ecologically diverse regions. Patterns of genetic variations among 54 E. onukii samples unveil the population structure and evolutionary history across different tea-growing regions in China. Our results demonstrate that the genomic changes in key pathways, including those linked to metabolism, circadian rhythms, and immune system functions, may underlie the successful spread and adaptation of E. onukii. This work highlights the genetic and molecular basis underlying the evolutionary success of a species with broad economic impacts, and provides insights into insect adaptation to host plants, which will ultimately facilitate more sustainable pest management.
Late margin recurrence after curative resection for hepatocellular carcinoma – Case report of two cases and review of this enigmatic entity
Authors: Desai Gunjan , Wagle Prasad K. 
Published: August 2022

ABSTRACT

Introduction:
The 5 year recurrence rate after curative treatment of hepatocellular carcinoma (HCC) is nearly 70%. However, there is limited data on recurrence patterns and its management. We present two cases of a very rare late recurrence pattern of HCC known as margin/scar recurrence.

Case reports:
Case 1: A 56 year old gentleman with hepatitis C infection, underwent angioembolization for ruptured HCC followed by future liver remnant augmentation and right trisectionectomy. After 20 months, he developed 4 subcentimetric pulmonary metastasis with a 11 × 10 cm margin recurrence. Resection with mesh reconstruction of diaphragm was performed. At 4.5 years follow up; he is on Sorafenib. Case 2: A 61 yr old gentleman with hepatitis B infection, underwent right lower transverse hepatectomy for a 16 × 15 cm HCC. On 5 years follow up, he had a margin recurrence of 16 × 12 cm. Excision with en-bloc omentectomy and colonic resection was performed. He is on sorafenib 400 mg per day at 4 months follow up.

Discussion:
Peritoneal recurrence is rare (2–16%). Scar/margin recurrence can be managed with complete surgical resection alone as the pathophysiological basis is localized expansive growth whereas, disseminated recurrences may be considered for cytoreductive surgery with/out hyperthermic intra-peritoneal chemotherapy as per the published case series or medically as per the current guidelines.

Conclusion:
Late margin recurrence after curative resection of HCC is a very rare entity. It can be managed surgically in a fit patient with preserved liver function so as to improve survival.

Highlights
A single-blind randomised controlled trial comparing clinical equivalence of Trulon® and Ethilon® polyamide sutures for the skin closure following laparotomy incisions
Authors: Subha Shree Rao Aruna Y. , Padmasri R. , Divya T. K. , Moharana Ashok Kumar , Deepak T. S. 
Published: August 2022

ABSTRACT

Background:
Laparotomy is a common procedure to gain access to the peritoneal cavity, for obstetrics, gynecological, and digestive system-related surgeries. Wound infection is among other complications of laparotomy. This study compared the rate of wound infection post-laparotomy skin closure using Trulon® and Ethilon® polyamide sutures.

Methods:
This multicentric, prospective, two-arm, parallel-group, randomized (1:1), single-blind study (CTRI/2020/09/027978) was conducted between January and July 2021, and included 102 women undergoing laparotomy-based obstetric/gynecological procedures. The primary endpoint, incidence of wound infection [superficial and deep surgical site infection(SSI)] occurring within 12 weeks of the surgery was compared between two treatment groups, Trulon® (n = 50) and Ethilon® (n = 52). The secondary endpoints, incidence of wound dehiscence, suture sinus, seroma, hematoma, skin disruption, suture loosening, re-suturing, duration of surgery, suture removal, hospital stay, intraoperative suture handling parameters, pain score, return to normal day-to-day activities, modified Hollander cosmesis score, subject satisfaction score, and adverse events were also evaluated.

Results:
Non-significant differences were observed in the incidence of SSI, wound dehiscence, suture sinus, seroma, hematoma, skin disruption, suture loosening, re-suturing, intraoperative handling parameter (except ease of passage), operative time, hospital stay, suture removal duration, pain score, time to return to day-to-day activities, modified Hollander cosmesis score, and subject satisfaction score between the two groups.

Conclusion:
Trulon® and Ethilon® polyamide sutures are clinically equivalent. For abdominal skin closure following laparotomy both the sutures deliver a lower chance of infection, minimal pain, higher satisfaction, and cosmesis score.

Registration of research:
This trial is registered prospectively at Clinical Trial Registry of India (CTRI Reg. No: CTRI/2020/09/027978; Registered on: 23/09/2020).

Highlights
Penetrating Electric Field Simulated by the MAGE and Comparison With ICON Observation
Authors: Wu Qian , Wang Wenbin , Lin Dong , Huang Chaosong , Zhang Yongliang 
Published: August 2022

AbstractUsing the newly developed, Multiscale Atmosphere‐Geospace Environment (MAGE) model, we simulated the penetrating electric field in the equatorial region under different interplanetary magnetic field (IMF) BZ conditions during September 2020. Two intervals were selected for detailed analysis and the latter one was compared with the vertical ion drift data from the NASA Ionospheric Connection Explorer (ICON) satellite. The MAGE simulations show that in southward IMF (S‐IMF) cases, the dawn‐dusk electric potential drop at the equator is about 12% of the cross polar cap potential difference. Based on the MAGE simulation, the dawn‐dusk potential drop at the equator varies nearly instantaneously on the order of a few minutes with the changes in the IMF BZ or interplanetary electric field, which in turn alters the vertical ion drift. The daytime changes of the equatorial vertical ion drift in response to the penetrating electric field related to the IMF BZ are only half of that during the nighttime. ICON data, though not inconsistent with the simulation, were not able to verify the occurrence of penetrating electric field because of its unfavorable location at the time. The MAGE simulation shows a pre‐reversal enhancement (PRE) during southward IMF cases, but the PRE was absent in the ICON IVM observations. Further observations and modeling are needed to resolve this discrepancy.