bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of betel habits on blood glucose levels in the Karo ethnic community, Karo district
Authors: Pane Yunita Sari , Machrina Yetty , Arrasyid Nurfida Khairina , Sari Mutiara Indah 
Published: January 2022

Background:Betel is a hereditary tradition from the ancestors of the Batak-Karo tribe, Indonesia. Karo people believe that betel is their unifier. The betel process begins with concocting a mixture of ingredients such as betel leaf, lime, gambier, areca nut, and with/without tobacco addition, then chewed slowly. Our previous study showed that gambier extracts (Uncaria gambier Roxb), can reduce blood glucose levels (BGL) in type 2 diabetes mellitus (T2DM) patients. This study aimed to analyze whether the habit of chewing betel can affect BGL in the Karo ethnic community in the Karo district.Methods:In total, 48 participants from the Karo community were divided into 4 groups (n=12 per group), namely: I. non-T2DM participants without betel habits; II. non-T2DM participants with betel habit; III. T2DM participants without betel habit and IV. T2DM participants with betel habit. The sampling technique was consecutive sampling. Data were collected by interviews and blood sampling (fasted and 2 hours postprandial (2hPP)). The collected data were analyzed by ANOVA thenpost hocBonferroni with a significance level of p-value <0.05.Results:This study showed that fasting BGL had no difference in non-T2DM participants without betel habit (group-I) compared to non-T2DM participants with betel habit (group-II) (84.33±12.32 vs 81.00± 4,84), and T2DM participants without betel habit (group-III) compared to T2DM participants with betel habit (group-IV) (196.25± 104.81 vs 150.00 ± 42.45), p>0.05. On the other hand, there was a significant difference in BGL 2hPP in group T2DM participants with betel habit compared to all groups (p<0.05). T2DM participants without betel habit group had the highest BGL levels compared to other groups.Conclusions:This study concluded that the habit of chewing betel containing gambier is effective in restraining the rate of increase in blood glucose levels. Further research is needed to see the mechanism.
Midkine as a novel biomarker for contrast-induced acute kidney injury
Authors: Abdelnabi Mahmoud , Almaghraby Abdallah , Benjanuwattral Juthipong , Ahmed Mohamed 
Published: January 2022

Contrast-induced acute kidney injury (CI-AKI) is an intrinsic kidney injury caused by contrast injection in susceptible individuals. Although the pathophysiological mechanisms by which contrast agents induce kidney injury have not been completely explained, direct and indirect effects, as well as hemodynamic perturbations, have been suggested. Renal effects develop immediately after contrast injection, and, theoretically, they could be detected early by using a sensitive biomarker. Recently, studies have been conducted to determine specific biomarkers to guide the early diagnosis of CI-AKI and thus improve the outcomes of these patients. Midkine (MK) is a heparin-binding growth factor that balances cell growth, survival, and migration. It has an antiapoptotic activity in nephrogenesis. Midkine has been investigated as an early biomarker for CI-AKI in patients undergoing percutaneous coronary intervention (PCI) for stable angina and was significantly higher in CI-AKI patients post PCU. However, more studies are needed to validate its efficacy in the early detection of CI-AKI.

Keywords: Contrast-induced nephropathy, contrast-induced acute kidney injury, midkine, biomarker.
Ileal neuroendocrine tumor without metastatic disease presenting with chronic diarrhea
Authors: Rahesh Jasmin , Mendiola Victor , Quraishi Baseer , Pathapati Srinivas 
Published: January 2022

Neuroendocrine tumors in the gastrointestinal tract, formerly known as carcinoid tumors, are benign in presentation but can quickly metastasize if not diagnosed during regular screenings, such as colonoscopies. Unfortunately, most patients do not present for treatment until late with metastasis when symptoms become severe. We report a 65-year-old Caucasian man who presented with chronic diarrhea for over 2 months; this presentation suggested liver metastasis, but he had no metastasis on evaluation.

Keywords: Gastrointestinal carcinoid tumor, colonoscopy, ileal metastasis, neuroendocrine tumor
Hospital-acquired pneumonia - no apparent seasonal variation: a single institution study
Authors: Wagner Clayton , John Albin , Egan Alec , Bradley Brandon , Ramirez Clarissa , Ahnood Elmira , Chavez Maricela , Aickareth Genesy , Griswold John 
Published: January 2022

Unlike the clear seasonal differences that have been recorded for certain respiratory infectious illnesses, variation in hospital-acquired pneumonia (HAP) rates by time of year has not been thoroughly investigated. The primary aim of this study was to determine whether HAP rates fluctuate during the year at the University Medical Center (UMC) in Lubbock, Texas. An internal data source maintained by UMC’s Infection Prevention & Control Office called MedMined that builds an algorithm using nosocomial infection markers (NIMs) was used to track HAP rates. The NIMs are microbiology results from various sample sources, including urine, stool, wound, respiratory secretions, and other, that provide a better understanding of a patient’s infection risk and status. MedMined respiratory NIMs data on quarterly scorecards from January 2015 to March 2020 were evaluated using one-way analysis of variance (ANOVA) and subsequently stratified to the departmental level (e.g., MICU, SICU, etc.) followed by a repeat one-way ANOVA for each of the selected departments. Analysis of hospital-wide and selected UMC hospital department respiratory NIMs data revealed no statistically significant difference in respiratory NIM rate by time of year (P = 0.25). Therefore, there is no apparent variation in HAP rates at UMC with respect to time of year either on a hospital-wide or a selected departmental level. Analysis of a national dataset might help determine whether this finding occurs at other institutions.

Key words: hospital-acquired pneumonia, intensive care units, seasons
Wild transthyretin amyloid cardiomyopathy recognition with noninvasive strategies: a case report and diagnostic approach for transthyretin-related cardiomyopathy
Authors: Del Rio-Pertuz Gaspar , Jenkins Leigh , Sethi Pooja , Argueta-Sosa Erwin 
Published: January 2022

Recent studies suggest that the prevalence of wild type transthyretin cardiomyopathy (wATTR-CM) is substantially higher than previously appreciated in older adults with heart failure. Advances in nuclear imaging using bone avid radiotracers permit diagnosis of transthyretin-related cardiomyopathy (ATTR-CM) without a tissue biopsy. We describe two wATTR-CM cases that were diagnosed using noninvasive methods and demonstrate this diagnostic approach for transthyretin-related cardiomyopathy.

Key words: amyloid, cardiomyopathy
Computationally Efficient Approximations for Distributionally Robust Optimization Under Moment and Wasserstein Ambiguity
Authors: Cheramin Meysam , Cheng Jianqiang , Jiang Ruiwei , Pan Kai 
Published: January 2022

Distributionally robust optimization (DRO) is a modeling framework in decision making under uncertainty in which the probability distribution of a random parameter is unknown although its partial information (e.g., statistical properties) is available. In this framework, the unknown probability distribution is assumed to lie in an ambiguity set consisting of all distributions that are compatible with the available partial information. Although DRO bridges the gap between stochastic programming and robust optimization, one of its limitations is that its models for large-scale problems can be significantly difficult to solve, especially when the uncertainty is of high dimension. In this paper, we propose computationally efficient inner and outer approximations for DRO problems under a piecewise linear objective function and with a moment-based ambiguity set and a combined ambiguity set including Wasserstein distance and moment information. In these approximations, we split a random vector into smaller pieces, leading to smaller matrix constraints. In addition, we use principal component analysis to shrink uncertainty space dimensionality. We quantify the quality of the developed approximations by deriving theoretical bounds on their optimality gap. We display the practical applicability of the proposed approximations in a production–transportation problem and a multiproduct newsvendor problem. The results demonstrate that these approximations dramatically reduce the computational time while maintaining high solution quality. The approximations also help construct an interval that is tight for most cases and includes the (unknown) optimal value for a large-scale DRO problem, which usually cannot be solved to optimality (or even feasibility in most cases). Summary of Contribution: This paper studies an important type of optimization problem, that is, distributionally robust optimization problems, by developing computationally efficient inner and outer approximations via operations research tools. Specifically, we consider several variants of such problems that are practically important and that admit tractable yet large-scale reformulation. We accordingly utilize random vector partition and principal component analysis to derive efficient approximations with smaller sizes, which, more importantly, provide a theoretical performance guarantee with respect to low optimality gaps. We verify the significant efficiency (i.e., reducing computational time while maintaining high solution quality) of our proposed approximations in solving both production–transportation and multiproduct newsvendor problems via extensive computing experiments.
Turismo local e o conviver em Ouro Preto em tempos de pandemia: lugar de encontro e de desencontro dos moradores
Authors: Alves Kerley Santos , Bretas Eberte Moura , Marques Welington Ribeiro Aquino 
Published: January 2022

Este trabalho tem como objetivo compreender, a partir das lógicas territoriais da cidade e das atividades do projeto Conviver, mesmo em tempos de pandemia, como suas ações podem representar possibilidades de desenvolver o sentimento de pertencimento e a inclusão do morador no contexto do turismo local. Foi construído à partir de revisão bibliográfica, entrevistas e observação participante nas atividades presenciais e remotas do projeto. Pode-se considerar que a cidade vem ao longo do tempo sofrendo modificações socioespaciais, ao usarem os espaços da cidade, ao darem significado e sentido a determinados lugares, esses moradores constroem e demarcam territórios por onde circulam. Antes mesmo do advento da pandemia, a centralidade das atividades, cada vez mais apontava para um aumento no grau de isolamento físico e simbólico dos moradores na cena turística, e consequentemente, da sensação de não fazer parte dele. No contexto da pandemia, as novas tecnologias possibilitaram a recriação de experiências na cidade e estímulo a novas formas de sociabilidades , proporcionando a troca de experiências entre os participantes em um espaço urbano híbrido de convívio.
Sinais e sintomas de violência sexual infantojuvenil: relatos de profissionais de saúde
Authors: Conceição Marimeire Morais da , Gomes Nadirlene Pereira , Whitaker Maria Carolina Ortiz , Silva Lucinéia Santos da , Ferreira Ithana Queila Borges Pizzani , Camargo Climene Laura de 
Published: January 2022

Objetivo: identificar sinais e sintomas apresentados por crianças e adolescentes que despertam nos profissionais de saúde a suspeita/identificação de violência sexual. Método: estudo com abordagem qualitativa realizado em 2019, com 30 profissionais de um hospital público da Bahia, mediante gravação das entrevistas com base em questionário semiestruturado e analisadas segundo Bardin. O projeto foi aprovado pelo Comitê de Ética em Pesquisa. Resultados: dor, sangramento, alteração ou laceração da genitália e/ou ânus e Infecções Sexualmente Transmissíveis constituem sinais e sintomas que despertam os profissionais para suspeita e/ou identificação da vivência de violência sexual infantojuvenil. Conclusão: os profissionais de saúde suspeitam e/ou identificavam a vivência de violência sexual quando crianças e adolescentes apresentam complicações relacionadas ao trato genital e anal, que podem resultar em óbito
O jogo movediço da liberdade: notas sobre estratégias de afirmação e resistência negra no campo educacional
Authors: Ramos da Costa Stephane 
Published: January 2022

O texto procura investigar alguns dos projetos educacionais organizados por indivíduos e entidades dos movimentos sociais negros entre os séculos XIX e XX. A partir de um mapeamento de ações organizadas por indivíduos de cor, incitaremos um debate sobre os projetos de letramento e identidade do Rio de Janeiro. O cotidiano da marginalidade da cidade carioca tem muito a nos ensinar sobre as redes de sociabilidade e estratégias de inserção/mobilidade social. A principal pergunta a ser respondida aqui se refere às dinâmicas que tornaram possíveis a construção de tantos espaços educativos e quais eram os padrões comportamentais dos sujeitos pesquisados.
Construção e validação de material educativo sobre tratamento farmacológico da Leucemia Mieloide Crônica
Authors: Casagrande Vanessa , Spadella Maria Angélica , Chagas Eduardo Federighi Baisi , Pinheiro Osni Lázaro 
Published: January 2022

A Leucemia Mieloide Crônica é uma doença hematológica caracterizada pela proliferação de leucócitos. O tratamento é feito por medicamentos administrados por via oral, porém pode ocorrer falha na adesão. Logo, ações educativas são importantes para conscientizar o paciente sobre o uso adequado destes medicamentos. O objetivo do estudo foi elaborar um material educativo com enfoque no tratamento da Leucemia Mieloide Crônica. Inicialmente verificou-se a adesão ao tratamento medicamentoso dos pacientes do Ambulatório de Onco-hematologia (n=36) aplicando a Escala de Adesão Terapêutica de Morisky (MMAS-8). Em seguida foi elaborada uma versão preliminar do material educativo com participação dos pacientes (n=10) e profissionais da área de saúde (n=10). Os participantes contribuíram na definição dos temas e posteriormente na validação do material educativo com relação ao conteúdo, linguagem, ilustrações, layout, motivação e cultura. Os itens que atingiram 80% de concordância foram considerados validados. Os resultados mostraram que a adesão dos pacientes ao tratamento merece investimentos e os avaliadores trouxeram importantes contribuições para a construção de um material sucinto, claro e com ilustrações. Os pacientes com Leucemia Mieloide Crônica merecem atenção em relação a realização de atividades educativas que possam contribuir com maiores esclarecimentos sobre a doença e também sobre a importância da adesão ao tratamento. Dessa forma, o material produzido nesse estudo, com a utilização de questionários validados na literatura e com a participação de especialistas na área, poderá ser utilizado como ferramenta para a realização de ações de “Educação em Saúde”, podendo auxiliar na otimização das taxas de adesão ao tratamento farmacológico.
Infográfico sobre doenças parasitárias neglicenciadas para séries iniciais
Authors: Barbosa Ana Jessily Camargo , Avila Thais Tania , Da Silva Rosane Meire Munhak , Silva-Sobrinho Reinaldo Antonio , Zilly Adriana 
Published: January 2022

O presente estudo tem o objetivo de descrever o caminho metodológico utilizado na construção de um infográfico animado, que retrata o tema Doenças Parasitárias Negligenciadas para as séries iniciais de uma escola do município de Foz do Iguaçu-PR, participante do Programa Saúde na Escola. O infográfico foi construído no site Powtoon®, um desenvolvedor online gratuito, que disponibiliza recursos de imagem, animação e vídeo. Utilizou-se o Design Instrucional, partindo de uma necessidade de aprendizagem para elaboração de uma solução de aprendizagem, através do Sistema ADDIE, cujas etapas são: Análise, Design, Desenvolvimento, Implementação e Avaliação. A produção do infográfico animado versou sobre doenças parasitárias negligenciadas pois os professores indicaram ser uma demanda de saúde da escola naquele momento e está disponível na plataforma de vídeos online de forma gratuita no link https://www.youtube.com/watch?v=vJrgjlUdnlA.
Roteiro prático para preceptoria em fisioterapia intensiva pediátrica de um hospital universitário.
Authors: Zandona Gisele da Silva Peixoto , Mesquita Deisiane da Da Silva , Moreira Meyrilane Vicente De Laias , Correa Camila Fortes , De Sousa Shanna Machado 
Published: January 2022

Resumo: É importante que o preceptor da unidade de terapia intensiva pediátrica tenha um planejamento estruturado para sequenciar os aprendizados com coerência dos temas e qualidade de conteúdo aos seus residentes, sendo esses os principais objetivos da preceptoria. Permitindo assim articular de forma prática e didática os diversos assuntos necessários para a formação concisa desse residente ao mesmo tempo, em que permite obter melhores parâmetros de avaliação. Este roteiro destina se também a desenvolver conhecimentos, habilidades, competências e atitudes necessárias à prática multiprofissional, possibilitando o desenvolvimento da capacidade crítica, reflexiva, participativa e transformadora, principalmente focada nas especificidades da área de concentração da residência. Este artigo trata-se de projeto de intervenção do tipo plano de preceptoria onde foi estruturado em formato de Roteiro Prático de Ensino e a avaliação quinzenal ou mensal foi seguindo a metodologia na pirâmide de Miller. O roteiro proposto foi resultado da interação com a rede de apoio com todos os atores da preceptoria; visando a melhoria na capacidade técnica assistencial desses residentes; e também a reversão das fraquezas antes imposta pela falta de argumentação teórico dos assuntos mais questionados durante o estágio e o planejamento para as atividades por meio do cronograma, possibilitou o cumprimento das temáticas, permitindo a organização dos processos de preceptoria, abordados e graduados por nível de dificuldades. Com utilização do método, foi possível a materialização de um conceito pedagógico e aumentou o impacto educacional das avaliações, bem como qualificou a formação dos residentes, permitindo assim um aprendizado direcionado.
Dynamically tunable broadband absorber/reflector based on graphene and VO2 metamaterials
Authors: Wang Xinyi , Ma Chi , Xiao Lihua , Li Xia , Yu Jiabin , Xiao Binggang 
Published: January 2022

We propose a difunctional tunable broadband absorber/reflector consisting of a periodic cross-shaped graphene array and a vanadium dioxide (

V
O

2

) layer. When

V
O

2

reflects the properties of metal, the proposed dual-function device is used as a reflector; when

V
O

2

reflects the nature of the dielectric, the difunctional device will be used as an absorber. The simulation results indicate that more than 90% absorption bandwidth can be available in the absorber in the frequency range of 56.1–59.0 THz, up to 100%. Moreover, over 80% absorption can be achieved over the frequency range of 88.5 to 90.2 THz. In addition, the bandwidth and absorption of the metamaterial absorber can be dynamically changed because of the Fermi energy level in graphene and the temperature tunability of

V
O

2

. The proposed device can be applied to manufacturing infrared spectrophotometers, on-dispersive infrared photometers, and Fourier transform infrared spectrometers. Therefore, it has potential application in the field of environmental monitoring.
Joint multi-parameter optical performance monitoring scheme based on trajectory information for a Stokes vector direct detection system
Authors: Yu Xinkuo , Bai Chenglin , Yang Lishan , Xu Hengying , Sun Weibin , Li Jianping 
Published: January 2022

In this study, we propose and verify a joint multi-parameter optical performance monitoring (OPM) scheme based on trajectory information for the Stokes vector direct detection (SVDD) system, for the first time, to the best of our knowledge. Here, the proposed scheme first performs quantification of the trajectory to construct trajectory information, which not only presents diversity of the received symbols in spatial dimension, but also records the jump pattern among symbols in time dimension. Subsequently, eigenanalysis is introduced to extract critical features hidden in trajectory information and simultaneously achieve the purpose of dimensionality reduction. The effectiveness of the scheme is verified through 14/28 GBaud SVDD binary phase shift keying/quadrature phase shift keying/-8 quadrature amplitude modulation (QAM)/-16QAM/-32QAM/-64QAM simulation systems. Under the scenario of joint modulation format (MF) identification and optical signal to noise ratio (OSNR) monitoring, the identification rates of all six kinds of MFs achieve 100% within their corresponding reasonable OSNR ranges. Besides that, the average mean absolute error (MAE) of the monitored OSNRs are obtained as 0.03 dB, 0.22 dB, 0.36 dB, 0.41 dB, 0.46 dB, and 0.49 dB for those six kinds of MFs, respectively. Under the scenario of multi-parameter OPM, SVDD-8QAM/-16QAM/-32QAM signals are 100% successfully identified when residual chromatic dispersion (RCD) is located in the ranges of 0–200 ps/nm, 0–190 ps/nm, and 0–160 ps/nm, respectively. The average MAE of OSNR monitoring and RCD estimation for these three commonly used MFs are 1.08 dB and 3.23 ps/nm, respectively. Moreover, the study also demonstrates the robustness for baud rates and a relatively simpler calculation complexity about the proposed OPM scheme.
Optimized wavelength selection for diffraction-based overlay measurement by minimum asymmetry factor variation with finite-difference time-domain simulation
Authors: Hsieh Hung-Chih , Cheng Jui-Ming , Yeh Yun-Chi 
Published: January 2022

A robust and wafer-less wavelength selection methodology was proposed. An overlay calculation model considering the asymmetric bottom grating structure showed that additional intensities diffracted from the asymmetric structure caused the overlay error. An asymmetry factor was introduced to describe the intensity ratio of the original overlay mark and a mark with bottom grating only. Based on the simulation results, the optimized wavelength was selected by analyzing the wavelength at which there is the minimum variation of the asymmetry factor. Four cases were tested by the simulation, and the maximum overlay error of the optimized wavelength selected by this method was 0.21 nm.