bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pattern of recurrence and survival after D2 right colectomy for cancer: is there place for a routine more extended lymphadenectomy?
Authors: Palmeri Matteo , Peri Andrea , Pucci Valentina , Furbetta Niccolò , Gallo Virginia , Di Franco Gregorio , Pagani Anna , Dauccia Chiara , Farè Camilla , Gianardi Desirée , Guadagni Simone , Bianchini Matteo , Comandatore Annalisa , Masi Gianluca , Cremolini Chiara , Borelli Beatrice , Pollina Luca Emanuele , Di Candio Giulio , Pietrabissa Andrea , Morelli Luca 
Published: July 2022

Abstract
Background
Conventional Right Colectomy with D2 lymphadenectomy (RC-D2) currently represent the most common surgical treatment of right-sided colon cancer (RCC). However, whether it should be still considered a standard of care, or replaced by a routine more extended D3 lymphadenectomy remains unclear. In the present study, we aim to critically review the patterns of relapse and the survival outcomes obtained from our 11-year experience of RC-D2.

Methods
Clinical data of 489 patients who underwent RC-D2 for RCC at two centres, from January 2009 to January 2020, were retrospectively reviewed. Patients with synchronous distant metastases and/or widespread nodal involvement at diagnosis were excluded. Post-operative clinical–pathological characteristics and survival outcomes were evaluated including the pattern of disease relapse.

Results
We enrolled a total of 400 patients with information follow-up. Postoperative morbidity was 14%. The median follow-up was 62 months. Cancer recurrence was observed in 55 patients (13.8%). Among them, 40 patients (72.7%) developed systemic metastases, and lymph-node involvement was found in 7 cases (12.8%). None developed isolated central lymph-node metastasis (CLM), in the D3 site. The estimated 3- and 5-year relapse-free survival were 86.1% and 84.4%, respectively. The estimated 3- and 5-year cancer-specific OS were 94.5% and 92.2%, respectively.

Conclusions
The absence of isolated CLM, as well as the cancer-specific OS reported in our series, support the routine use of RC-D2 for RCC. However, D3 lymphadenectomy may be recommended in selected patients, such as those with pre-operatively known CLM, or with lymph-node metastases close to the origin of the ileocolic vessels.
Innovative mobile-health led participatory approach to comprehensive screening and treatment of diabetes (IMPACT diabetes): rationale, design, and baseline characteristics
Authors: Bassi Abhinav , Arfin Sumaiya , John Oommen , Praveen Devarsetty , Arora Varun , Kalra O.P. , Madhu S. V. , Jha Vivekanand 
Published: July 2022

Abstract
Background
India has 66 million people with diabetes, of which a large proportion do not receive adequate care. The primary health centres can serve as platforms for early detection of diabetes and continuum of care.

Objectives
This project evaluates a community-level technology-enabled system-level intervention based around the community health workers and primary-care physicians. We hypothesize that incorporation of a mobile clinical decision support system, with other process-level changes will improve identification and management of individuals with diabetes in primary care settings.

Methods
A cluster-randomized trial in sixteen villages/peri-urban areas in Andhra Pradesh and Haryana will test the feasibility and preliminary effectiveness of this intervention. The effectiveness of the extended care intervention will be evaluated by the difference in HbA1c (glycosylated hemoglobin) measured at baseline and end-line between the two study arms. Qualitative interviews of physicians, ASHA, and community members will ascertain the intervention acceptability and feasibility.

Results
A total of 1785 adults (females: 53.2%; median age: 50 years) were screened. ASHAs achieved 100% completeness of data for anthropometric, blood-pressure, and blood-glucose measures. At baseline, 63% of the participants were overweight/obese, 27.8% had elevated blood pressure, 20.3% were at high-risk for cardiovascular disease (CVD), and 21.3% had elevated blood glucose. Half of the individuals with diabetes were newly diagnosed.

Conclusion
Technology enabled transfer of simple clinical procedures from physicians to nonphysician health workers can support the provision of healthcare in under-served communities. Community health workers can successfully screen and refer patients with diabetes and/or CVD to physicians in primary healthcare system.
Building coherence and impact: differences in Finnish school level curriculum making
Authors: Soini Tiina , Pyhältö Kirsi , Haverinen Kaisa , Sullanmaa Jenni , Leskinen Esko , Pietarinen Janne 
Published: July 2022

AbstractThe study aims to gain a better understanding on how curriculum making regulated by reform’s implementation strategy contributes to teachers’ and teacher communities perceived curriculum coherence, and further to the impact that reform has on school development. The two-level path modelling was utilised for analysing clustered data including the 75 schools and 1556 individual teachers from these schools during the most recent Finnish core curriculum reform. The results showed that the participatory strategy, including balancing the steering and transformative dialogue, seemed to be crucial both for promoting the individual teacher’s and professional communities’ shared capacity to process the big ideas of the new core curriculum document at the school level. Moreover, it promoted perceived curriculum coherence and further impact on school development. Participatory curriculum making strategy, balancing the steering and transformative dialogue in the curriculum making, seemed to be crucial both for supporting the individual teacher’s and professional communities’ in processing the ideas of the new core curriculum. Change management and knowledge sharing promoted perceived curriculum coherence and further reform’s perceived impact on school development for both individual teacher and teacher communities.
Maximum likelihood estimation for tensor normal models via castling transforms
Authors: Derksen Harm , Makam Visu , Walter Michael 
Published: July 2022

Abstract
In this paper, we study sample size thresholds for maximum likelihood estimation for tensor normal models. Given the model parameters and the number of samples, we determine whether, almost surely, (1) the likelihood function is bounded from above, (2) maximum likelihood estimates (MLEs) exist, and (3) MLEs exist uniquely. We obtain a complete answer for both real and complex models. One consequence of our results is that almost sure boundedness of the log-likelihood function guarantees almost sure existence of an MLE. Our techniques are based on invariant theory and castling transforms.
Thinking and Writing Truth. Rahel Levin Varnhagen's ‘Diaries’ and Philosophical Notes
Authors: Wernli Martina 
Published: July 2022

AbstractThis paper collects some of Rahel Levin Varnhagen's thinking about truth. It aims to contextualize Levin Varnhagen's non-conventional writing within German Romanticism. Her so-called ‘diaries’ vary between aphorisms, personal reflections, problem-oriented sketches and apodictic definitions concerning anthropology and society. Truth and honesty are shaped in opposition to lies but also build a base for the process of thinking itself. According to Levin Varnhagen, truth leads to the real quality of things and towards understanding—thinking truth is an epistemic process. The paper follows Levin Varnhagen's quest for and definition of truth by re-reading her diaries as philosophical practice. Thematizing the possibilities of critical female thought by a (Jewish) woman of the early nineteenth century (with a ‘twice incorrect name’, as Barbara Hahn has put it) and the restrictions in education and publishing, the paper addresses furthermore intersectional questions of gender and religion.
Drag forces at the ice-sheet bed and resistance of hard-rock obstacles: the physics of glacial ripping
Authors: Krabbendam Maarten , Dioguardi Fabio , Arnhardt Christian , Roberson Sam , Hall Adrian M. 
Published: July 2022

AbstractGlacial ripping involves glaciotectonic disintegration of rock hills and extensive removal of rock at the ice-sheet bed, triggered by hydraulic jacking caused by fluctuating water pressures. Evidence from eastern Sweden shows that glacial ripping caused significant subglacial erosion during the final deglaciation of the Fennoscandian ice sheet, distinct from abrasion and plucking (quarrying). Here we analyse the ice drag forces exerted onto rock obstacles at the base of an ice sheet, and the resisting forces of such rock obstacles: glaciotectonic disintegration requires that ice drag forces exceed the resisting forces of the rock obstacle. We consider rock obstacles of different sizes, shapes and fracture patterns, informed by natural examples from eastern Sweden. Our analysis shows that limited overpressure events, unfavourable fracture patterns, low-transmissivity fractures, slow ice and streamlined rock hamper rock hill disintegration. Conversely, under fast ice flow and fluctuating water pressures, disintegration is possible if the rock hill contains subhorizontal, transmissive fractures. Rock steps on previously smooth, abraded surfaces, caused by hydraulic jacking, also enhance drag forces and can cause disintegration of a rock hill. Glacial ripping is a physically plausible erosion mechanism, under realistic glaciological conditions prevalent near ice margins.
Mobilising through vaccination: the case of polio in France (1950–60s)
Authors: Baylac-Paouly Baptiste , Caballero María-Victoria , Porras María-Isabel 
Published: July 2022

AbstractPoliomyelitis is a disease whose incidence steadily increased during the second half of the twentieth century on both sides of the Atlantic. If in the United States the epidemics which afflicted young children each summer became a major public health issue, in France, polio was considered less pressing than other diseases. This article, based on original archives from the Pasteur and Mérieux institutes, analyses the polio control strategies and policies implemented by France from the mid-1950s to the end of the 1960s. The article examines the role of two key actors and institutions that mobilised the French health authorities against the disease: Pierre Lépine and the Institut Pasteur as well as Charles Mérieux and the Institut Mérieux. Lépine developed an effective injected polio vaccine which was first used before being supplemented with the oral polio vaccine. If the two main protagonists and their institutions worked together, they each implemented different actions and manoeuvres, at different times with the aim to raise awareness of the fight against the disease. The national and international relations of the key French actors were decisive in the development and production of the polio vaccines and their application. This work contributes to understanding processes of polio vaccines choice at the level of national institutions and analyses the political and scientific networks built in support of polio vaccination, to finally move towards compulsory vaccination. Ultimately, this study describes the historical processes by which this disease became conflated with a biotechnology of collective protection in France.
Prefrontal-cerebellar dynamics during post-success and post-error cognitive controls in major psychiatric disorders
Authors: Cao Hengyi 
Published: July 2022

AbstractBackgroundDifficulty in cognitive adjustment after a conflict or error is a hallmark for many psychiatric disorders, yet the underlying neural correlates are not fully understood. We have previously shown that post-success and post-error cognitive controls are associated with distinct mechanisms particularly related to the prefrontal-cerebellar circuit, raising the possibility that altered dynamic interactions in this circuit may underlie mental illness.MethodsThis study included 136 patients with three diagnosed disorders [48 schizophrenia (SZ), 49 bipolar disorder (BD), 39 attention deficit hyperactivity disorder (ADHD)] and 89 healthy controls who completed a stop-signal task during fMRI scans. Brain activations for concurrent, post-success, and post-error cognitive controls were analyzed and compared between groups. Dynamic causal modeling was applied to investigate prefrontal-cerebellar effective connectivity patterns during post-success and post-error processing.ResultsNo significant group differences were observed for brain activations and overall effective connectivity structures during post-success and post-error conditions. However, significant group differences were shown for the modulational effect on top-down connectivity from the prefrontal cortex to the cerebellum during post-error trials (pFWE = 0.02), which was driven by reduced modulations in both SZ and ADHD. During post-success trials, there were significantly decreased modulational effect on bottom-up connectivity from the cerebellum to the prefrontal cortex in ADHD (pFWE = 0.04) and decreased driving input to the cerebellum in SZ (pFWE = 0.04).ConclusionsThese findings suggest that patients with SZ and ADHD are associated with insufficient neural modulation on the prefrontal-cerebellar circuit during post-success and post-error cognitive processing, a phenomenon that may underlie cognitive deficits in these disorders.
Pretending to be a believer: on understanding religious fictionalism as a role-playing game
Authors: Palmqvist Carl-Johan 
Published: July 2022

AbstractAccording to religious fictionalism, a non-believer can participate in religious life by playing a game of make-believe. Considering how games of make-believe build on imagination and pretence, I argue that religious fictionalism requires the non-believing participant to engage in role-playing. Turning to the literature on role-playing games, I demonstrate how religious fictionalism conforms to a qualified definition of such games. I also explore the theoretical consequences of adopting the role-playing perspective, by considering its impact on two key issues concerning religious fictionalism.
Electoral coalition signals and voter perceptions
Authors: Jang Jinhyuk , Crabtree Charles , Golder Sona N. 
Published: July 2022

AbstractHow do electoral coalition signals affect voters' perceptions of party positions and coalition behavior in parliamentary democracies? Scholars have found that coalition signals can influence how voters view policy positions of parties. Extending research on the impact of government coalition participation on voter perceptions, a recent study found that Spanish voters update their perceptions of party positions when they receive a signal that a party joined an electoral coalition, believing it to be farther to the left (right) if the signal was of a left- (right-)leaning coalition. That study also found, in agreement with the literature, that electoral coalition signals lead to expectations of future coalition behavior. Much of the literature on electoral coalitions focuses on parliamentary democracies in Europe that use proportional representation. Since the effects of electoral coalitions might vary across contexts, we conduct a similar survey experiment in Japan, a parliamentary democracy that uses a mixed electoral system with an important disproportional component. We find no evidence that electoral coalition signals affect how Japanese voters view the ideological positions of parties, a result that matches a similar analysis conducted in Sweden. However, some coalition signals – if they contain new information – do increase Japanese respondents' expectations that certain coalitions are more likely to form in the future.
State of Ireland's mental health: findings from a nationally representative survey
Authors: Hyland Philip , Vallières Frédérique , Shevlin Mark , Bentall Richard P. , Butter Sarah , Hartman Todd K. , Karatzias Thanos , Martinez Anton P. , McBride Orla , Murphy Jamie , Fox Robert 
Published: July 2022

Abstract

Aims
Current information about the prevalence of various mental health disorders in the general adult population of the Republic of Ireland is lacking. In this study, we examined the prevalence of 12 common mental disorders, the proportion of adults who screened positive for any disorder, the sociodemographic factors associated with meeting criteria for a disorder and the associations between each disorder and history of attempted suicide.

Methods
A non-probability nationally representative sample (N = 1110) of adults living in Ireland completed self-report measures of 12 mental health disorders. Effect sizes were calculated using odds ratios from logistic regression models, and population attributable risk fractions (PAFs) were estimated to quantify the associations between each disorder and attempted suicide.

Results
Prevalence rates ranged from 15.0% (insomnia disorder) to 1.7% (histrionic personality disorder). Overall, 42.5% of the sample met criteria for a mental health disorder, and 11.1% had a lifetime history of attempted suicide. Younger age, being a shift worker and trauma exposure were independently associated with a higher likelihood of having a mental health disorder, while being in university was associated with a lower likelihood of having a disorder. ICD-11 complex posttraumatic stress disorder, borderline personality disorder and insomnia disorder had the highest PAFs for attempted suicide.

Conclusions
Mental health disorder prevalence in Ireland is relatively high compared to international estimates. The findings are discussed in relation to important mental health policy implications.
Effective tumor cell abrogation via Venetoclax-mediated BCL-2 inhibition in KMT2A-rearranged acute B-lymphoblastic leukemia
Authors: Richter Anna , Lange Sandra , Holz Clemens , Brock Luisa , Freitag Thomas , Sekora Anett , Knuebel Gudrun , Krohn Saskia , Schwarz Rico , Hinz Burkhard , Murua Escobar Hugo , Junghanss Christian 
Published: July 2022

AbstractDysregulation of the intrinsic BCL-2 pathway-mediated apoptosis cascade is a common feature of hematological malignancies including acute B-lymphoblastic leukemia (B-ALL). The KMT2A-rearranged high-risk cytogenetic subtype is characterized by high expression of antiapoptotic protein BCL-2, likely due to the direct activating binding of KMT2A fusion proteins to the BCL2 gene. The BCL-2 inhibitor venetoclax (VEN) has proven great clinical value in other blood cancers, however, data on B-ALL is sparse and past studies have not so far described the effects of VEN on gene and protein expression profiles. Using cell lines and patient-derived in vivo xenograft models, we show BCL-2 pathway-mediated apoptosis induction and decelerated tumor cell counts in KMT2A-rearranged B-ALL but not in other cytogenetic subtypes. VEN treatment of cell line- and patient-derived xenografts reduced blast frequencies in blood, bone marrow, and spleen, and tumor cell doubling times were increased. Growth rates are further correlated with VEN concentrations in blood. In vitro incubation with VEN resulted in BCL-2 dephosphorylation and targeted panel RNA sequencing revealed reduced gene expression of antiapoptotic pathway members BCL2, MCL1, and BCL2L1 (BCL-XL). Reinforced translocation of BAX proteins towards mitochondria induced caspase activation and cell death commitment. Prolonged VEN application led to upregulation of antiapoptotic proteins BCL-2, MCL-1, and BCL-XL. Interestingly, the extrinsic apoptosis pathway was strongly modulated in SEM cells in response to VEN. Gene expression of members of the tumor necrosis factor signaling cascade was increased, resulting in canonical NF-kB signaling. This possibly suggests a previously undescribed mechanism of BCL-2-independent and NF-kB-mediated upregulation of MCL-1 and BCL-XL. In summary, we herein prove that VEN is a potent option to suppress tumor cells in KMT2A-rearranged B-ALL in vitro and in vivo. Possible evasion mechanisms, however, must be considered in subsequent studies.
Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining
Authors: Kaminski Andrea M. , Chiruvella Kishore K. , Ramsden Dale A. , Bebenek Katarzyna , Kunkel Thomas A. , Pedersen Lars C. 
Published: July 2022

AbstractDNA double-strand breaks (DSBs) threaten genomic stability, since their persistence can lead to loss of critical genetic information, chromosomal translocations or rearrangements, and cell death. DSBs can be repaired through the nonhomologous end-joining pathway (NHEJ), which processes and ligates DNA ends efficiently to prevent or minimize sequence loss. Polymerase λ (Polλ), one of the Family X polymerases, fills sequence gaps of DSB substrates with a strict specificity for a base-paired primer terminus. There is little information regarding Polλ’s approach to engaging such substrates. We used in vitro polymerization and cell-based NHEJ assays to explore the contributions of conserved loop regions toward DSB substrate specificity and utilization. In addition, we present multiple crystal structures of Polλ in synapsis with varying biologically relevant DSB end configurations, revealing how key structural features and hydrogen bonding networks work in concert to stabilize these tenuous, potentially cytotoxic DNA lesions during NHEJ.
A litmus test for classifying recognition mechanisms of transiently binding proteins
Authors: Chakrabarti Kalyan S. , Olsson Simon , Pratihar Supriya , Giller Karin , Overkamp Kerstin , Lee Ko On , Gapsys Vytautas , Ryu Kyoung-Seok , de Groot Bert L. , Noé Frank , Becker Stefan , Lee Donghan , Weikl Thomas R. , Griesinger Christian 
Published: July 2022

AbstractPartner recognition in protein binding is critical for all biological functions, and yet, delineating its mechanism is challenging, especially when recognition happens within microseconds. We present a theoretical and experimental framework based on straight-forward nuclear magnetic resonance relaxation dispersion measurements to investigate protein binding mechanisms on sub-millisecond timescales, which are beyond the reach of standard rapid-mixing experiments. This framework predicts that conformational selection prevails on ubiquitin’s paradigmatic interaction with an SH3 (Src-homology 3) domain. By contrast, the SH3 domain recognizes ubiquitin in a two-state binding process. Subsequent molecular dynamics simulations and Markov state modeling reveal that the ubiquitin conformation selected for binding exhibits a characteristically extended C-terminus. Our framework is robust and expandable for implementation in other binding scenarios with the potential to show that conformational selection might be the design principle of the hubs in protein interaction networks.
Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians
Authors: Wong Lily L. , Bruxvoort Christina G. , Cejda Nicholas I. , Delaney Matthew R. , Otero Jannette Rodriguez , Forsthoefel David J. 
Published: July 2022

AbstractLipid metabolism plays an instructive role in regulating stem cell state and differentiation. However, the roles of lipid mobilization and utilization in stem cell-driven regeneration are unclear. Planarian flatworms readily restore missing tissue due to injury-induced activation of pluripotent somatic stem cells called neoblasts. Here, we identify two intestine-enriched orthologs of apolipoprotein b, apob-1 and apob-2, which mediate transport of neutral lipid stores from the intestine to target tissues including neoblasts, and are required for tissue homeostasis and regeneration. Inhibition of apob function by RNAi causes head regression and lysis in uninjured animals, and delays body axis re-establishment and regeneration of multiple organs in amputated fragments. Furthermore, apob RNAi causes expansion of the population of differentiating neoblast progeny and dysregulates expression of genes enriched in differentiating and mature cells in eight major cell type lineages. We conclude that intestine-derived lipids serve as a source of metabolites required for neoblast progeny differentiation.