bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning with desktop virtual reality: changes and interrelationship of self-efficacy, goal orientation, technology acceptance and learning behavior
Authors: Luo Yan , Du Huan 
Published: June 2022

AbstractWith advantages such as ease of use and low cost, desktop virtual reality (VR) technologies are increasingly being used in practical learning. This study aims to clarify the relationship among students' self-efficacy, goal orientation, technology acceptance [e.g., perceived usefulness (PU) and perceived ease of use (PEOU)] and learning behavior, and the changes of these variables as well as gender difference in the early and late stages of course study when desktop VR technology is applied to business simulation learning. A pretest–posttest group design with two repeated measures is employed for this study. During a 10-week period, students' self-efficacy, goal orientation, technology acceptance and learning behavior are measured among junior and senior students majoring in Business Administration from a four-year undergraduate university who used desktop VR technology for practical learning. Course scores for these students are also collected and used to measure whether desktop VR is helping to improve their learning outcomes. Findings indicate that there is a significant correlation between self-efficacy, PEOU, PU and goal orientation, which further affects learners' learning behavior and learning outcomes when desktop VR is used for practical learning. After learning with desktop VR, self-efficacy, perceived ease of use and usefulness, and surface learning behaviors increased, while mastery goal orientation decreased. Furthermore, self-efficacy, PEOU and PU are found to be significantly higher in males than in females.
A systematic review on digital literacy
Authors: Tinmaz Hasan , Lee Yoo-Taek , Fanea-Ivanovici Mina , Baber Hasnan 
Published: June 2022

AbstractThe purpose of this study is to discover the main themes and categories of the research studies regarding digital literacy. To serve this purpose, the databases of WoS/Clarivate Analytics, Proquest Central, Emerald Management Journals, Jstor Business College Collections and Scopus/Elsevier were searched with four keyword-combinations and final forty-three articles were included in the dataset. The researchers applied a systematic literature review method to the dataset. The preliminary findings demonstrated that there is a growing prevalence of digital literacy articles starting from the year 2013. The dominant research methodology of the reviewed articles is qualitative. The four major themes revealed from the qualitative content analysis are: digital literacy, digital competencies, digital skills and digital thinking. Under each theme, the categories and their frequencies are analysed. Recommendations for further research and for real life implementations are generated.
Digital technology supporting English learning among Indonesian university students
Authors: Hidayat Didin Nuruddin , Lee Jee Young , Mason Jon , Khaerudin Teguh 
Published: June 2022

AbstractWorldwide, information technology now plays a substantial role in the daily life of most people, whether in the developed world or in developing countries, such as Indonesia. In this fourth most populated country in the world, information technology is widely used for everyday communications and entertainment purposes, as well as for supporting education. Using a survey of 496 students enrolled in a university in Jakarta, this paper reports on a study aimed at assessing the experiences of young Indonesian students undertaking online learning and the potential of this platform for English learning. The findings show that online activities, skills, and perceived usefulness were positively correlated with positive experiences of learning English online. In particular, the perceived usefulness of the Internet and the ability to use different functions of digital devices and applications had a stronger correlation with increased benefits of online English learning. The study generates implications for Indonesian education suggesting a review of the roles of English instructors in promoting English learning through technology, improvement in English instructors’ skills in utilizing technology in their teaching, and support of relevant stakeholders as well as the preparation of English teacher preparation programme to support pre-service teachers for teaching with technology.
Investigating the predicting role of COVID-19 preventive measures on building brand legitimacy in the hospitality industry in Tanzania: mediation effect of perceived brand ethicality
Authors: Amani David , Ismail Ismail Juma 
Published: June 2022

AbstractThe COVID-19 pandemic undesirably affected the hospitality industry, and therefore, preventive measures have been advocated as crucial when revitalizing or rejuvenating the industry. This study investigated the interplay of predicting role of COVID-19 preventive measures, perceived brand ethicality, and brand legitimacy in the hospitality industry in Tanzania during the period of reviving the industry. Furthermore, the study examines the mediating role of perceived brand ethicality in the relationship between COVID-19 preventive measures and brand legitimacy. Data were collected from a total of 405 customers of hospitality organizations recruited via an on-site survey. Data analyses were done using structural equation modeling. Overall, the results have shown that COVID-19 preventive measures had a direct positive effect on brand legitimacy. Additionally, COVID-19 preventive measures could enhance brand legitimacy indirectly via perceived brand ethicality. The study has significant implications for different hospitality organizations and operators in Tanzania and other countries during post the COVID-19 period.
Panitumumab (PAN) plus mFOLFOX6 versus bevacizumab (BEV) plus mFOLFOX6 as first-line treatment in patients with RAS wild-type (WT) metastatic colorectal cancer (mCRC): Results from the phase 3 PARADIGM trial.
Authors: Yoshino Takayuki , Watanabe Jun , Shitara Kohei , Yasui Hirofumi , Ohori Hisatsugu , Shiozawa Manabu , Yamazaki Kentaro , Oki Eiji , Sato Takeo , Naitoh Takeshi , Komatsu Yoshito , Kato Takeshi , Hihara Masamitsu , Soeda Junpei , Yamamoto Kouji , Akagi Kiwamu , Ochiai Atsushi , Uetake Hiroyuki , Tsuchihara Katsuya , Muro Kei 
Published: June 2022

LBA1 Background: PARADIGM is the first prospective trial to test the superiority of PAN vs. BEV in combination with standard doublet first-line chemotherapy for patients (pts) with RAS WT mCRC and left-sided primary tumors. Methods: This open-label, multicenter trial in Japan (NCT02394795) randomly selected pts with chemotherapy-naive RAS WT mCRC to PAN + mFOLFOX6 or BEV + mFOLFOX6. Overall survival (OS) as primary endpoint was hierarchically tested in patients with left-sided tumors, followed by those in the full-analysis set (FAS) population. Key secondary endpoints included progression-free survival (PFS), response rate (RR), and curative resection (R0) rate. Results: From May 2015 to June 2017, 823 pts were randomized; 12 did not receive protocol treatment and 9 were excluded due to major deviation of inclusion criteria. A total of 400 pts received PAN and 402 pts received BEV as FAS; 312 and 292 pts had left-sided primary tumors, respectively. OS was analyzed after 448 OS events in left-sided pts with a median follow-up of 61 months. PAN significantly improved OS vs. BEV in both populations: left-sided (HR, 0.82; 95.798% CI, 0.68-0.99, p = .031, which crossed the boundary of significance [0.042]), and FAS (HR, 0.84; 95% CI, 0.72-0.98; p = .030, with < 0.05 as the boundary). Although PFS was comparable between treatment groups, RR and R0 resection rates were higher with PAN compared with BEV (Table). HR for OS in the right-sided population was 1.09. No new safety signal was observed. Conclusions: PAN significantly improved OS vs. BEV in combination with mFOLFOX6 in pts with RAS WT and left-sided mCRC, establishing a standard first-line combination regimen for this population. Clinical trial information: NCT02394795. [Table: see text]
Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling
Authors: Morthorst Stine Kjær , Nielsen Camilla , Farinelli Pietro , Anvarian Zeinab , Rasmussen Christina Birgitte R. , Serra-Marques Andrea , Grigoriev Ilya , Altelaar Maarten , Fürstenberg Nicoline , Ludwig Alexander , Akhmanova Anna , Christensen Søren Tvorup , Pedersen Lotte Bang 
Published: June 2022

ABSTRACT
The kinesin-3 motor KIF13B functions in endocytosis, vesicle transport and regulation of ciliary length and signaling. Direct binding of the membrane-associated guanylate kinase (MAGUK) DLG1 to the MAGUK-binding stalk domain of KIF13B relieves motor autoinhibition and promotes microtubule plus-end-directed cargo transport. Here, we characterize angiomotin (AMOT) isoform 2 (p80, referred to as Ap80) as a novel KIF13B interactor that promotes binding of another MAGUK, the polarity protein and Crumbs complex component PALS1, to KIF13B. Live-cell imaging analysis indicated that Ap80 is concentrated at and recruits PALS1 to the base of the primary cilium, but is not a cargo of KIF13B itself. Consistent with a ciliary function for Ap80, its depletion led to elongated primary cilia and reduced agonist-induced ciliary accumulation of SMO, a key component of the Hedgehog signaling pathway, whereas Ap80 overexpression caused ciliary shortening. Our results suggest that Ap80 activates KIF13B cargo binding at the base of the primary cilium to regulate ciliary length, composition and signaling.
Interindividual variation in maximum aerobic metabolism varies with gill morphology and myocardial bioenergetics in Gulf killifish
Authors: Rees Bernard B. , Reemeyer Jessica E. , Irving Brian A. 
Published: June 2022

ABSTRACT
This study asked whether interindividual variation in maximum and standard aerobic metabolic rates of the Gulf killifish, Fundulus grandis, correlates with gill morphology and cardiac mitochondrial bioenergetics, traits reflecting critical steps in the O2 transport cascade from the environment to the tissues. Maximum metabolic rate (MMR) was positively related to body mass, total gill filament length and myocardial oxygen consumption during maximum oxidative phosphorylation (multiple R2=0.836). Standard metabolic rate (SMR) was positively related to body mass, total gill filament length and myocardial oxygen consumption during maximum electron transport system activity (multiple R2=0.717). After controlling for body mass, individuals with longer gill filaments, summed over all gill arches, or greater cardiac respiratory capacity had higher whole-animal metabolic rates. The overall model fit and the explanatory power of individual predictor variables were better for MMR than for SMR, suggesting that gill morphology and myocardial bioenergetics are more important in determining active rather than resting metabolism. After accounting for body mass, heart ventricle mass was not related to variation in MMR or SMR, indicating that the quality of the heart (i.e. the capacity for mitochondrial metabolism) was more influential than heart size. Finally, the myocardial oxygen consumption required to offset the dissipation of the transmembrane proton gradient in the absence of ATP synthesis was not correlated with either MMR or SMR. The results support the idea that interindividual variation in aerobic metabolism, particularly MMR, is associated with variation in specific steps in the O2 transport cascade.
Noise intensity and its impact on the perception and concentration level among forest harvesting workers in industrial forest plantation, North Sumatera, Indonesia
Authors: Muhdi Muhdi , Hanafiah Diana Sofia , Sahar Asmarlaili , Telaumbanua Alex Angenano 
Published: June 2022

Background: Noise has the potential to affect the comfort and health of workers. The objective of this research was to find out the effect of noise caused by the timber harvesting process using chainsaws on the concentration of workers in an industrial forest plantation. Methods: This experimental study included 20 respondents which consisted of 10 chainsaw operators/helpers and 10 non-chainsaw operators. All respondents were exposed to the sound of a chainsaw in three different conditions (idle, half gas and racing conditions) with and without personal protective equipment (PPE). The sound intensity produced by the chainsaw and the noise received by the respondents were measured using a sound level meter. Respondents’ perception toward noise was recorded using a Likert scale. Respondents’ concentration level was assessed by giving 25 math-questions to be answered within 10 minutes. Wilcoxon sign rank test was used to analysed paired data. Results: The average sound intensity received by respondents’ left and right ears were lower than the average sound intensity produced by the chainsaw. The use of earmuffs leads to better perception towards noise when compared with the use of earplugs and the absence of any PPE. The Wilcoxon test result showed that noise did not have significant impact on the concentration level of chainsaw operators, whilst the contrary result is true for non-chainsaw operators. Conclusions: The research indicated that although the noise produced by the chainsaw machine was considered noisy for both chainsaw operators and non-chainsaw operator, it did not have a significant effect on the concentration level of chainsaw operators and only affected the non-chainsaw operators. Therefore, given that the non-chainsaw operators were still affected by the noise, noise control measures are still needed to ensure occupational safety and health for the workers.
Comparison of invasive histological and molecular methods in the diagnosis of Helicobacter pylori from gastric biopsies of Sudanese patients: a cross-sectional study
Authors: Elnosh Maram , Altayb Hisham , Hamedelnil Yousif , Elshareef Wafa , Abugrain Aliaa , Osman Esraa , Albasha Aalaa , Abdelhamid Abdelhamid , Moglad Ehssan , AbdAlla Ahmed , Ismail Ahmed 
Published: June 2022

Background: The continuous rise in the number of patients suffering from Helicobacter pylori is probably due to the changes in modern life. Nowadays, patients suffering from gastrointestinal problems are diagnosed through invasive and non-invasive techniques. The choice of a diagnostic test is influenced by factors such as the tests' sensitivity and specificity, the clinical conditions, and the cost-effectiveness of the testing strategy. This study aimed to compare molecular detection methods of H. pylori by polymerase chain reaction (PCR) targeting the 16S rRNA, ureA and glmM genes with an invasive histopathological technique. Methods: 290 gastric biopsies were collected using gastrointestinal endoscopy from patients with gastritis symptoms in different hospitals in Khartoum state. Two gastric biopsies were collected from each patient for PCR and histopathology. Results: A total of 103 (35.5%) samples were positive by histopathological examination, 88 (30.3%) by 16S rRNA, 39 (13.4%) by glmM gene, and 56 (19.3%) by ureA gene. The highest sensitivity was observed in 16S rRNA (46.6%), followed by glmM (24.3%) and ureA (23.3%). While the best specificity was observed in glmM gene (92.5%), followed by ureA (82.3%) and 16S rRNA (78.6%). Conclusion: PCR test targeting the 16S rRNA gene exhibited the best results for molecular detection of H. pylori compared to other genes.
Decomposition and Adaptive Sampling for Data-Driven Inverse Linear Optimization
Authors: Gupta Rishabh , Zhang Qi 
Published: June 2022

This work addresses inverse linear optimization, where the goal is to infer the unknown cost vector of a linear program. Specifically, we consider the data-driven setting in which the available data are noisy observations of optimal solutions that correspond to different instances of the linear program. We introduce a new formulation of the problem that, compared with other existing methods, allows the recovery of a less restrictive and generally more appropriate admissible set of cost estimates. It can be shown that this inverse optimization problem yields a finite number of solutions, and we develop an exact two-phase algorithm to determine all such solutions. Moreover, we propose an efficient decomposition algorithm to solve large instances of the problem. The algorithm extends naturally to an online learning environment where it can be used to provide quick updates of the cost estimate as new data become available over time. For the online setting, we further develop an effective adaptive sampling strategy that guides the selection of the next samples. The efficacy of the proposed methods is demonstrated in computational experiments involving two applications: customer preference learning and cost estimation for production planning. The results show significant reductions in computation and sampling efforts. Summary of Contribution: Using optimization to facilitate decision making is at the core of operations research. This work addresses the inverse problem (i.e., inverse optimization), which aims to infer unknown optimization models from decision data. It is, conceptually and computationally, a challenging problem. Here, we propose a new formulation of the data-driven inverse linear optimization problem and develop an efficient decomposition algorithm that can solve problem instances up to a scale that has not been addressed previously. The computational performance is further improved by an online adaptive sampling strategy that substantially reduces the number of required data points.
Negative Advertising and Competitive Positioning
Authors: Bostanci Gorkem , Yildirim Pinar , Jerath Kinshuk 
Published: June 2022

Negative advertising provides information about the weaknesses of a competitor’s product. We study negative advertising with a focus on how its regulation impacts product positioning for profit-maximizing firms. We build a model of informative advertising competition, where product positioning is endogenous, and consumers have rational expectations. We show that despite the informational benefits of negative advertising, permitting it (as the Federal Trade Commission in the United States does) may lead to reduced product differentiation and lower consumer welfare, even in markets where firms do not use negative advertising in equilibrium. We then extend our model to political competition, where a candidate’s objective is to obtain a larger share of votes than the competitor. We show that political competition supports higher positional differentiation, along with more negative advertising than product competition, in line with observed high use of negative advertising in political races and their rarer use in product competition. This paper was accepted by Dmitri Kuksov, marketing. Funding: P. Yildirim thanks Mack Institute and the Dean’s Research Funds of the Wharton School for their generous funding of this study. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4439 .
Is there a correlation between humeral osteoarthritis and glenoid morphology according to Walch?
Authors: Vetter Philipp , Magosch Petra , Habermeyer Peter 
Published: June 2022

Aims The aim of this study was to determine whether there is a correlation between the grade of humeral osteoarthritis (OA) and the severity of glenoid morphology according to Walch. We hypothesized that there would be a correlation. Methods Overal, 143 shoulders in 135 patients (73 females, 62 males) undergoing shoulder arthroplasty surgery for primary glenohumeral OA were included consecutively. Mean age was 69.3 years (47 to 85). Humeral head (HH), osteophyte length (OL), and morphology (transverse decentering of the apex, transverse, or coronal asphericity) on radiographs were correlated to the glenoid morphology according to Walch (A1, A2, B1, B2, B3), glenoid retroversion, and humeral subluxation on CT images. Results Increased humeral OL correlated with a higher grade of glenoid morphology (A1-A2-B1-B2-B3) according to Walch (r = 0.672; p < 0.0001). It also correlated with glenoid retroversion (r = 0.707; p < 0.0001), and posterior humeral subluxation ( r = 0.452; p < 0.0001). A higher humeral OL (odds ratio (OR) 1.17; 95% confidence interval (CI) 1.03 to 1.32; p = 0.013), posterior humeral subluxation (OR 1.11; 95% CI 1.01 to 1.22; p = 0.031), and glenoid retroversion (OR 1.48; 95% CI 1.30 to 1.68; p < 0.001) were independent factors for a higher glenoid morphology. More specifically, a humeral OL of ≥ 13 mm was indicative of eccentric glenoid types B2 and B3 (OR 14.20; 95% CI 5.96 to 33.85). Presence of an aspherical HH in the coronal plane was suggestive of glenoid types B2 and B3 (OR 3.34; 95% CI 1.67 to 6.68). Conclusion The criteria of humeral OL and HH morphology are associated with increasing glenoid retroversion, posterior humeral subluxation, and eccentric glenoid wear. Therefore, humeral radiological parameters might hint at the morphology on the glenoid side. Cite this article: Bone Jt Open 2022;3(6):463–469.
Generation of nonclassical states of light via truncation of mixed states
Authors: Mattos E. P. , Vidiella-Barranco A. 
Published: June 2022

A possible way of generating nonclassical states of light is via the truncation of a given state in the Fock basis. In recent work, we presented an alternative scheme for such quantum scissors [Phys. Rev. A 104, 033715 (2021)PLRAAN1050-294710.1103/PhysRevA.104.033715], employing a nondegenerate parametric amplifier, a beam splitter, and photodetectors. An advantage of this setup is that it does not require the generation of Fock states beforehand, as in previous proposals. Here we extend this treatment to mixed input states. We show the possibilities of generating truncated states with either a maximum Fock number

N

or states having a minimum Fock number

N

. We discuss two specific examples of states to be truncated: (i) the thermal state and (ii) the phase-diffused coherent state. In either case, the generated field states can present sub-Poissonian statistics as well as non-Gaussian character. These nonclassical properties can be adjusted by changing the parameters of the scissors, e.g., the amplifier strength and the beam-splitter transmittance.