bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repercussão da violência no desenvolvimento das dores craniofaciais em mulheres: revisão integrativa de literatura
Authors: Silva Deborah Bezerra Sobreira da , Nascimento Michele Gomes do , Anjos Hemanuelly  Albuquerque dos , Vieira Juliana da Silva , Lins Daniele Janiszewski , Gheno Caciana Farias da Silva , Muniz Caroline Isabele Felix , Sampaio Guilherme Marinho , Assis João Paulo de Melo Garcia 
Published: February 2022

A violência é um fenômeno complexo e de raízes profundas, multifacetado e que atinge todos os grupos sociais, instituições e faixas etárias. É histórica e incide em homens e mulheres de forma diferenciada, uma vez que o sexo feminino é significativamente mais atingido. Por ocorrer preferencialmente no ambiente doméstico, é vista pela sociedade como um problema individual do casal ou da mulher que sofre violência e, por muitas vezes, causa danos que permanecem com a vítima ao longo de toda sua vida. Dentre as consequências de tais abusos é destaca-se as dores craniofaciais, dores crônicas que atingem estruturas da face. A literatura descreve uma relação direta entre a violência e o desenvolvimento e agravamento de dores crônicas, contudo, poucos estudos na área de DTM e Dor Orofacial (DOF) foram feitos. Desta forma, o presente estudo teve como objetivo realizar uma revisão integrativa dos textos já publicados sobre o assunto, avaliando assim, a repercussão da violência no desenvolvimento de dores craniofaciais em mulheres.
NADPH Oxidase 3 Deficiency Protects From Noise-Induced Sensorineural Hearing Loss
Authors: Rousset Francis , Nacher-Soler German , Kokje Vivianne Beatrix Christina , Sgroi Stéphanie , Coelho Marta , Krause Karl-Heinz , Senn Pascal 
Published: February 2022

The reactive oxygen species (ROS)-generating NADPH oxidase NOX3 isoform is highly and specifically expressed in the inner ear. NOX3 is needed for normal vestibular development but NOX-derived ROS have also been implicated in the pathophysiology of sensorineural hearing loss. The role of NOX-derived ROS in noise-induced hearing loss, however, remains unclear and was addressed with the present study. Two different mouse strains, deficient in NOX3 or its critical subunit p22phox, were subjected to a single noise exposure of 2 h using an 8–16 kHz band noise at an intensity of 116–120 decibel sound pressure level. In the hours following noise exposure, there was a significant increase in cochlear mRNA expression of NOX3 in wild type animals. By using RNAscope in situ hybridization, NOX3 expression was primarily found in the Rosenthal canal area, colocalizing with auditory neurons. One day after the noise trauma, we observed a high frequency hearing loss in both knock-out mice, as well as their wild type littermates. At day seven after noise trauma however, NOX3 and p22phox knockout mice showed a significantly improved hearing recovery and a marked preservation of neurosensory cochlear structures compared to their wild type littermates. Based on these findings, an active role of NOX3 in the pathophysiology of noise-induced hearing loss can be demonstrated, in line with recent evidence obtained in other forms of acquired hearing loss. The present data demonstrates that the absence of functional NOX3 enhances the hearing recovery phase following noise trauma. This opens an interesting clinical window for pharmacological or molecular intervention aiming at post prevention of noise-induced hearing loss.
Room Temperature Electrodeposition of Ready-to-Use TiOx for Uniform p-n Heterojunction Over Nanoarchitecture
Authors: Cao Yufeng , Qiao Huajian , Zou Yalong , An Na , Zhou Yang , Liu Deyu , Kuang Yongbo 
Published: February 2022

The photocathodes are essential in photoelectrochemical systems for harvesting solar energy as green fuels. However, the light-absorbing p-type semiconductor in them usually suffers from carrier recombination issues. An effective strategy to address it is fabricating the p-n heterojunction to create an interfacial electric field. However, plenty of deposition process of the n-type layer for this purpose requires either sophisticated instruments or subsequent treatments, which may damage the vulnerable p-type structure. Herein, we report a mild approach for a ready-to-use n-type layer with full functionality. Structural analyses proved the successful coating of a uniform titania layer (up to 40 nm) over Cu2O without damaging its structure. Owing to the high Ti3+ content, the layer possesses excellent charge transport ability and requires no additional annealing. The heterojunction effectively facilitates the carrier separation and positively shifts the photocurrent onset potential for 0.2 V. The Mott–Schottky plot and the impedance study reveal an enhanced carrier collection with reduced charge transfer resistances. Such a nano-heterojunction can be further loaded with the hydrogen evolution catalyst, which almost doubles the photocurrent with an extended lifetime than that of the pristine Cu2O nanoarray. This approach puts forward a potentially scalable and efficient choice for fabricating photoelectrochemical devices.
Multiscale Study on Deterioration Characteristics of Soil-Rock Mixtures Under the Immersion-Air dry Circulation
Authors: Li Li , Zhang Shixin , Qiang Yue , Xia Xiaozhou , Li Shaohong , Chen Longfei 
Published: February 2022

Soil-rock mixtures (S-RMs) composed of rock slope colluvium and landslide deposits are common in superficial hazards of bank slopes. The physical and mechanical properties of S-RMs are closely related to environmental conditions, especially reservoir water level fluctuation. Therefore, immersion-air dry (I-AD) circulations tests were carried out to simulate the phenomenon in this study. The macroscopic, mesoscopic, and microcosmic studies of S-RMs are carried out after experiencing cycles (N) of 0, 1, 5, and 10, respectively. Conventional triaxial tests, particle analysis tests, and scanning electron microscopy were performed to study the physical and mechanical properties of S-RMs. According to test results, the maximum deviator stress of S-RMs samples with confining pressures of 100, 200, 300, and 400 kPa after ten cycles is reduced by 41.13, 37.11, 32.17, and 30.20%. With the increase in N there is a significant trend towards reducing the strength of S-RMs, and the strength deterioration after the first I-AD circulation reached 15.73%. After I-AD circulations, the content of fine particles in S-RMs decreases, the grain-size characteristic and non-uniformity coefficient increase significantly, and the gradation of S-RMs shows discontinuity. Moreover, the repeated changes of water pressure have an irreversible impact on the microstructure of S-RMs, which will cause an increase in pore size and a higher pore disorder. In addition, it is found from the established strength parameter evolution equation that when N approaches infinity, S-RMs decomposes the weathering into cohesionless silt with an angle of repose of 0.90322φ0. The study results in this paper clarify the deterioration characteristics of wading S-RMs, and might be used in the bank slopes stability analysis.
Intensive, Short-Term Presenting With a Science Outreach Program Enhances Positive Science Attitudes and Interest in Lifelong Learning About Science
Authors: Sripaoraya Nantida , Spronken-Smith Rachel , Longnecker Nancy 
Published: February 2022

This study investigated impacts of intensive, short-term participation as a science outreach presenter on attitudes towards science and interest in lifelong learning about science. Participants included high school and university students who volunteered to assist as presenters over 1 week when Science Caravan—an extensive science outreach program in Thailand, run by the National Science Museum—visited their locality. This study employed mixed methods over two phases. Phase One involved three questionnaires. Two questionnaires were administered to current presenters (N = 690), pre-presenting (before training) and immediately post-presenting at 12 locations of the Science Caravan tour in 2017–2018. A third questionnaire collected data from previous, alumni presenters (n = 726). Phase Two involved interviews with current presenters (n = 19) and alumni presenters (n = 19). While presenters already had positive attitudes towards science, the brief but intensive experience of being a Science Caravan presenter enhanced science attitudes in four scales—with more positive attitudes about Self-concept in science, Value of science to society, and Future participation in science, and decreased Anxiety about science presenting. Participation had a greater impact of reducing anxiety in female presenters compared to male presenters. The experience of presenting with Science Caravan led to the development of more positive attitudes towards science and increased interest in lifelong learning activities regarding science, including presenters’ interest in science-related education. The increased interest in lifelong learning activities was correlated with positive attitudes about and self-efficacy in science. This study provides evidence that a short-term, intensive experience of science outreach can lead to increases in positive attitudes towards science and lifelong learning.
Efficient Swelling and Mercerization of Bagasse Fiber by Freeze-Thaw-Assisted Alkali Treatment
Authors: Cao Liming , Zhu Jiatian , Deng Baojuan , Zeng Fanyan , Wang Shanshan , Ma Yun , Qin Chengrong , Yao Shuangquan 
Published: February 2022

The mercerization of fiber is an important method for the high-value utilization of cellulose. In this study, the bagasse fiber was mercerized by freeze–thaw-assisted alkali treatment (FT/AT). The effects of freezing temperature, freezing time, alkali concentration, and thawing temperature on cellulose and hemicellulose removal were studied. The optimal freezing temperature was −40°C, freezing time was 8.0 h, alkali concentration was 5.0%, and thawing temperature was 30°C. The highest removal rate of hemicellulose was 75.64%. It was 5.80% higher than that of alkali treatment (AT). The alkaline degradation of cellulose was inhibited. The penetration of alkaline solution to fiber was promoted by the assistance of freeze-thaw pretreatment. The effective alkali concentration (5.0%) of cellulose I completely transformed into cellulose II decreased by 66.67% compared with traditional alkaline mercerization (15.0%). The high-efficiency mercerization of fiber was achieved by FT/AT. It provides theoretical support for promoting the high-value utilization of lignocellulosic biomass.
The First Case Report of a Patient With Oligodendroglioma Harboring CHEK2 Germline Mutation
Authors: Li Xueen , Xue Hao , Luo Ningning , Han Tiantian , Li Mengmeng , Jia Deze 
Published: February 2022

Introduction:CHEK2 (Checkpoint kinase 2) germline mutations were associated with an elevated risk of breast cancer, colorectal cancer, and other familiar cancers. Loss-of-function variants in CHEK2 are known to be pathogenic. Germline CHEK2 mutations have also been observed in medulloblastoma and primary glioblastomas. Currently, there is no direct evidence supporting the relationship of CHEK2 with central nervous system tumors.Case presentation: A case of an oligodendroglioma patient harboring the germline CHEK2 p.R137* mutation was reported. CHEK2 p.R137* mutation occurred in the forkhead-associated domain. Given the absence of other known genetic predisposing risk factors, we considered that oligodendroglioma might be associated with the CHEK2 mutation. The patient in our case might have a high risk of breast cancer and other multiple primary tumors. Her siblings and offspring would have a 50% chance of having the same variant.Conclusion: We reported a case of an oligodendroglioma patient with a family history of gastrointestinal tumors harboring the germline CHEK2 pathogenic variation. This is the first report of the association between the CHEK2 pathogenic variation and brain tumors that warrants further validation in larger cohorts.
Genetic Background of Kirgiz Ethnic Group From Northwest China Revealed by Mitochondrial DNA Control Region Sequences on Massively Parallel Sequencing
Authors: Wang Hongdan , Chen Man , Chen Chong , Fang Yating , Cui Wei , Lei Fanzhang , Zhu Bofeng 
Published: February 2022

The mitochondrial DNA (mtDNA) has been used to trace population evolution and apply to forensic identification due to the characteristics including lack of recombination, higher copy number and matrilineal inheritance comparing with nuclear genome DNA. In this study, mtDNA control region sequences of 91 Kirgiz individuals from the Northwest region of China were sequenced to identify genetic polymorphisms and gain insight into the genetic background of the Kirgiz ethnic group. MtDNA control region sequences of Kirgiz individuals presented relatively high genetic polymorphisms. The 1,122 bp sequences of mtDNA control region could differ among unrelated Kirgiz individuals, which suggested the mtDNA control region sequences have a good maternal pedigree tracing capability among different Kirgiz individuals. The neutrality test, mismatch distribution, Bayesian phylogenetic inference, Bayesian skyline analysis, and the median network analyses showed that the Kirgiz group might occurred population expansion, and the expansion could be observed at about ∼53.41 kilo years ago (kya) when ancestries of modern humans began to thrive in Eurasia. The pairwise population comparisons, principal component analyses, and median network analyses were performed based on haplogroup frequencies or mtDNA control region sequences of 5,886 individuals from the Kirgiz group and the 48 reference populations all over the world. And the most homologous haplotypes were found between Kirgiz individuals and the East Asian individuals, which indicated that the Kirgiz group might have gene exchanges with the East Asian populations.
Classification and Regression Models for Genomic Selection of Skewed Phenotypes: A Case for Disease Resistance in Winter Wheat (Triticum aestivum L.)
Authors: Merrick Lance F. , Lozada Dennis N. , Chen Xianming , Carter Arron H. 
Published: February 2022

Most genomic prediction models are linear regression models that assume continuous and normally distributed phenotypes, but responses to diseases such as stripe rust (caused by Puccinia striiformis f. sp. tritici) are commonly recorded in ordinal scales and percentages. Disease severity (SEV) and infection type (IT) data in germplasm screening nurseries generally do not follow these assumptions. On this regard, researchers may ignore the lack of normality, transform the phenotypes, use generalized linear models, or use supervised learning algorithms and classification models with no restriction on the distribution of response variables, which are less sensitive when modeling ordinal scores. The goal of this research was to compare classification and regression genomic selection models for skewed phenotypes using stripe rust SEV and IT in winter wheat. We extensively compared both regression and classification prediction models using two training populations composed of breeding lines phenotyped in 4 years (2016–2018 and 2020) and a diversity panel phenotyped in 4 years (2013–2016). The prediction models used 19,861 genotyping-by-sequencing single-nucleotide polymorphism markers. Overall, square root transformed phenotypes using ridge regression best linear unbiased prediction and support vector machine regression models displayed the highest combination of accuracy and relative efficiency across the regression and classification models. Furthermore, a classification system based on support vector machine and ordinal Bayesian models with a 2-Class scale for SEV reached the highest class accuracy of 0.99. This study showed that breeders can use linear and non-parametric regression models within their own breeding lines over combined years to accurately predict skewed phenotypes.
Serum Myoglobin Is Associated With Postoperative Acute Kidney Injury in Stanford Type A Aortic Dissection
Authors: Yang Chen , Hou Peng , Wang Dongxu , Wang Zhenguo , Duan Weixun , Liu Jincheng , Yu Shiqiang , Fu Feng , Jin Zhenxiao 
Published: February 2022

BackgroundThe correlation between rhabdomyolysis and postoperative acute kidney injury has been reported in several surgical procedures. As a good predictor of rhabdomyolysis-related acute kidney injury, an elevated serum myoglobin level was often observed after total aortic arch replacement combined with frozen elephant trunk implantation. However, the correlation between serum myoglobin and acute kidney injury in such patients had not been established.MethodsTotally 398 stanford type A aortic dissection patients who underwent total aortic arch replacement combined with frozen elephant trunk implantation were enrolled in this retrospective study. The correlations between serum myoglobin and acute kidney injury as well as the 30-day mortality were assessed.ResultsOverall, 268(67.3%) patients had acute kidney injury (KDIGO stage 1 or higher) and 75(18.8%) had severe acute kidney injury (KDIGO stage 2&amp;3). Patients who developed acute kidney injury had higher level of perioperative serum myoglobin than patients without acute kidney injury. After adjusting for known acute kidney injury risk factors, logarithmically transformed preoperative serum myoglobin [OR = 1.58 (95% CI, 1.26–1.95), P &lt; 0.001] and postoperative day 1 serum myoglobin [OR = 3.47 (95%CI, 2.27–5.29), P &lt; 0.001] were associated with severe acute kidney injury. These correlation persisted after adjustment for decline in filtration via change in serum creatinine (ΔCr) and biomarkers of cardiac and kidney injury, including N-terminal prohormone of brain natriuretic peptide, cardiac troponin I, creatine kinase-MB, serum creatinine and Cystatin C. Compared with the clinical model, sMb considerably improved the risk discrimination and reclassification for AKI.ConclusionFor stanford type A aortic dissection patients underwent total aortic arch replacement with frozen elephant trunk implantation, serum myoglobin can improve postoperative acute kidney injury risk classification. Rhabdomyolysis may be an important supplement to the existing knowledge on the mechanism of acute kidney injury.
Association Between Dystonia-Related Genetic Loci and Parkinson's Disease in Eastern China
Authors: Yang Wen-Yi , Jiang Si-Si , Pu Jia-Li , Jin Chong-Yao , Gao Ting , Zheng Ran , Tian Jun , Zhang Bao-Rong 
Published: February 2022

BackgroundParkinson's disease (PD) and dystonia are closely related in terms of pathophysiology and clinical manifestations, but their common genetic characteristics remain unclear. Some genome-wide association studies (GWASs) and replication studies have revealed correlations between single nucleotide polymorphisms (SNPs) of the ARSG, BDNF, NALCN, OR4X2, KIAA1715, and OR4B1 genes and dystonia. This study was conducted to assess the association between these genetic loci and PD in a population from Eastern China.MethodsWe genotyped the SNPs (rs11655081 of ARSG; rs6265 of BDNF; rs61973742, rs1338051, rs9518384, and rs9518385 of NALCN; rs67863238 of OR4X2; rs10930717 of KIAA1715; and rs35875350 of OR4B1) in a cohort of 474 patients with PD and 439 healthy controls from East China. To determine the genotypes of these SNPs, we used an Agena MassARRAY Typer 4.0. Odds ratios (ORs) and 95% CIs were computed to evaluate the correlations between these SNPs and the risk of PD.ResultsThere were significant differences in the genotype distribution (OR = 0.649, 95% CI = 0.478–0.880) and minor allele frequency (MAF) (OR = 0.703, 95% CI = 0.533–0.929) of SNP rs61973742 (NALCN) between patients with PD and healthy controls. A significant difference was detected in the genotype distribution of rs11655081 (ARSG) (OR = 1.486, 95% CI = 1.080–2.045).ConclusionSingle nucleotide polymorphisms rs11655081 (ARSG) and rs61973742 (NALCN) may be associated with PD. The C allele of rs11655081 may increase the risk of PD, whereas the G allele of rs61973742 may be a protective factor.
Associations of Racial and Ethnic Category, Age, Comorbidities, and Socioeconomic Factors on Concordance to NCCN Guidelines for Patients With High-Risk Biliary Tract Cancers After Surgery
Authors: Huang Lauren F. , Hong Augustine , Cioffi Gino , Alahmadi Asrar , Tang Tin-Yun , Ocuin Lee M. , Patil Nirav , Bajor David L. , Saltzman Joel N. , Mohamed Amr , Selfridge Eva , Webb Hooper Monica , Barnholtz-Sloan Jill , Lee Richard T. 
Published: February 2022

BackgroundBiliary tract cancers (BTC) have a limited prognosis even for localized cancers, emphasizing the importance of multidisciplinary management. NCCN guidelines recommend adjuvant chemotherapy (CT) +/- radiotherapy (RT) for high-risk disease. We analyzed the association between racial and ethnic category along with other demographic factors and concordance to NCCN guidelines among patients following surgery for high-risk BTC.MethodsSubjects were identified from the National Cancer Database (NCDB) for BTC patients who underwent surgery and found to have metastatic lymph nodes (LN+) or positive surgical margins (M+) from 2004 to 2015. We defined concordance to NCCN guidelines as receiving surgery + CT +/- RT and non-concordance to the guidelines as surgery +/- RT. Descriptive studies and multivariate logistic regression analysis was performed.ResultsA total of 3,792 patients were identified with approximately half being female (55.4%) and between the ages of 50-69 (52.8%). Most were White (76.3%) followed by Black (10.6%), Hispanic (8.5%), and Asian (5.3%). The BTC included extrahepatic cholangiocarcinoma (CCA) (48.6%), gallbladder cancer (43.5%), and intrahepatic CCA (7.9%). Most patients had an M- resection (71.9%) but also had LN+ disease (88.0%). There were no significant differences between racial groups in disease presentation (histological grade, tumor stage) and surgical outcomes (LN+, M+, hospital readmission, and 90 day post-surgery mortality). Hispanic patients as compared to White patients were less likely to be insured (85.7% vs 96.3%, p&lt;0.001) and less likely to be treated at an academic facility (42.1% vs 52.1%, p=0.008). Overall, almost one-third (29.7%) of patients received non-concordant NCCN guideline care with Hispanic patients having the highest proportion of non-concordance as compared to Whites patients (36.1% vs 28.7%, p=0.029). On multivariate analysis, Hispanic ethnicity (HR=1.51, 95% CI: 1.15-1.99) remained significantly associated with non-concordance to NCCN guidelines.ConclusionThis study indicates that Hispanic patients with high-risk BTC are significantly less likely to receive NCCN-concordant treatment in comparison to White patients. More research is needed to confirm and understand the observed disparities and guide targeted interventions at the system-level.