bluuebunny/crossref_metadata_2025_split huggingface dataset:
Axions in string theory — slaying the Hydra of dark radiation
Authors: Cicoli Michele , Hebecker Arthur , Jaeckel Joerg , Wittner Manuel 
Published: September 2022

Abstract
It is widely believed that string theory easily allows for a QCD axion in the cosmologically favored mass range. The required small decay constant, fa ≪ MP, can be implemented by using a large compactification volume. This points to the Large Volume Scenario which in turn makes certain cosmological predictions: first, the closed string axion behaves similarly to a field-theoretic axion in the pre-inflationary scenario, i.e. the initial value can be tuned but one is constrained by isocurvature fluctuations. In addition, the volume represents a long-lived modulus that may lead to an early matter-dominated phase. Finally, the decay of the volume modulus to its own axion tends to overproduce dark radiation. In this paper we aim to carefully analyze the cosmology by studying models that not only allow for a QCD axion but also include inflation. Quite generally, limits on isocurvature fluctuations restrict us to relatively low-scale inflation, which in the present stringy context points to Kähler moduli inflation. As a novel feature we find that the lightest (volume) modulus couples strongly to the Higgs. It hence quickly decays to the SM, thus resolving the original dark radiation problem. This decay is much faster than that of the inflaton, implying that reheating is determined by the inflaton decay. The inflaton could potentially reintroduce a dark radiation problem since it decays to lighter moduli and their axions with equal rates. However, due its mixing with the QCD-saxion, the inflaton has also a direct decay rate to the SM, enhanced by the number of SM gauge bosons. This results in an amount of dark radiation that is consistent with present limits but potentially detectable in future measurements.
Boost-invariant superfluid flows
Authors: Rodgers Ronnie , Subils Javier G. 
Published: September 2022

Abstract
We present some exact solutions to the ideal hydrodynamics of a relativistic superfluid with an almost-conformal equation of state. The solutions have stress tensors which are invariant under Lorentz boosts in one direction, and represent superfluid generalisations of the Bjorken and Gubser flows. We also study corrections to the flows in first-order hydrodynamics, arguing that dissipation is dominated by the shear viscosity. We present some simple numerical solutions for these viscous corrections. Finally, we estimate the size of corrections to the flows arising when the spontaneously broken U(1) symmetry responsible for superfluidity is only approximate, giving the corresponding Goldstone boson a small non-zero mass. We find that the massless solutions can still provide good approximations at sufficiently small spatial rapidities.
Bubble nucleation and quantum initial conditions in classical statistical simulations
Authors: Tranberg Anders , Ungersbäck Gerhard 
Published: September 2022

Abstract
Classical-statistical lattice simulations provide a useful approximation to out-of-equilibrium quantum field theory, but only for systems exhibiting large occupation numbers, and only for phenomena that are not intrinsically quantum mechanical in nature. In certain special circumstances, it can be appropriate to initialize such real-time simulations with quantum-like zero-point fluctuations. We will revisit these points, and investigate reports that quantum bubble nucleation rates in 1+1 dimensions can be computed through the classical evolution of such a quantum-like initial condition [1]. We find that although intriguing, the reported numerical agreement between classical-statistical simulations and the quantum nucleation rate in 1+1 dimensions is a coincidence, which is not specific to this choice of initialisation, is parameter and lattice cut-off dependent and disappears as the number of space-dimensions increases from 1+1 to 2+1.
Depth-based reconstruction method for incomplete functional data
Authors: Elías Antonio , Jiménez Raúl , Shang Han Lin 
Published: September 2022

AbstractThe problem of estimating missing fragments of curves from a functional sample has been widely considered in the literature. However, most reconstruction methods rely on estimating the covariance matrix or the components of its eigendecomposition, which may be difficult. In particular, the estimation accuracy might be affected by the complexity of the covariance function, the noise of the discrete observations, and the poor availability of complete discrete functional data. We introduce a non-parametric alternative based on depth measures for partially observed functional data. Our simulations point out that the benchmark methods perform better when the data come from one population, curves are smooth, and there is a large proportion of complete data. However, our approach is superior when considering more complex covariance structures, non-smooth curves, and when the proportion of complete functions is scarce. Moreover, even in the most severe case of having all the functions incomplete, our method provides good estimates; meanwhile, the competitors are unable. The methodology is illustrated with two real data sets: the Spanish daily temperatures observed in different weather stations and the age-specific mortality by prefectures in Japan. They highlight the interpretability potential of the depth-based method.
A Comparison Between Piezosurgery and Conventional Osteotomies in Rhinoplasty on Post-Operative Oedema and Ecchymosis: A Systematic Review
Authors: Kisel Janneta , Khatib Manaf , Cavale Naveen 
Published: September 2022

Abstract
Piezosurgery use has become increasingly prevalent in osteotomies. Piezoelectric ultrasound waves can cut bone effectively, and some studies have shown reduced post-operative morbidities compared to conventional osteotomies. Oedema and ecchymosis are common complications of rhinoplasty and can impact patient satisfaction, wound healing, and recovery. We aim to provide an up-to-date comparison of post-operative oedema and ecchymosis in piezosurgery and conventional osteotomies. A literature search was conducted using the following online libraries; Pubmed, Cochrane, Science Direct, and ISRCTN (International Standard Randomised Controlled Trial Number). English publications between 2015 and 2020 were included. A systematic review was completed, and a comparison of oedema and ecchymosis in piezosurgery and conventional osteotomies was examined alongside other outcomes such as pain, mucosal injury, and surgery time. Eight randomised controlled trials (RCTs) met our criteria with a combined total of 440 patients: 191 male and 249 female. Piezosurgery had statistically significant (p < 0.05) reduction in short-term oedema compared to conventional osteotomies in 75% of the papers included, and in 50% this persisted across the whole follow-up period. Similarly, ecchymosis scoring was initially statistically lower (p < 0.05) in piezosurgery in 87.5% of the RCTs, and in 75% this persisted across the whole follow-up period. A reduction in pain (p < 0.05) and mucosal injury (p < 0.05) was also seen in piezoelectric osteotomies. The length of surgery time varied. Piezoelectric osteotomies reduce oedema and ecchymosis compared to conventional osteotomies, in addition to improving pain and mucosal injury. However, disadvantages such as length of surgery time and cost have been reported.

Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Chronology of Thyroid Cancer
Authors: Miyauchi Akira 
Published: September 2022

AbstractIntroductionThe basic nature of cancer includes unlimited growth, invasion, and metastasis. The TNM staging system is very simple and popular. It indicates the degree of the anatomical spread of the disease but does not include tumor growth. Collins reported that human tumors grow exponentially, which can be expressed in doubling time.Patients and MethodsWe found that in patients with medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) serum calcitonin and thyroglobulin levels changed exponentially over time, respectively, and that doubling times of these values were very strong prognostic factors. Doubling time has two major limitations. Doubling rate resolves these limitations. Using doubling rate, we performed kinetic analyses on tumor volume during active surveillance of micro‐PTC.ResultsOur kinetic studies on patients with biochemically persistent disease revealed that 17% of MTC and 51% of PTC showed decrease in serum tumor marker levels over time. During active surveillance of micro‐PTC, 17% of the patients showed clear decrease in their tumor volume. The evidences currently available are limited. However, our data indicate the following: Growth slowdown and regression are very common phenomena in the natural history of micro‐PTC, clinical PTC in young and middle‐aged patients, and hereditary MTC. The biologic characteristics of cancers of the same name, such as PTC, are diverse and vary widely with age.ConclusionsDoubling time and doubling rate are very powerful tools to provide the most appropriate management for the patients with thyroid cancers. Knowing the natural history of thyroid cancer is essential for the best disease management of thyroid cancer.
Management of chronic rheumatic diseases in women 18–45 years of age in Asia Pacific: insights from patient and clinician surveys
Authors: Tanaka Yoshiya , Barrett Claire , Hirano Yuji , Ikeda Kei , Paizis Kathy , Sameshima Azusa , Mountian Irina , Wong Priscilla C. 
Published: September 2022

Abstract
Objective
Perspectives of women aged 18–45 years with chronic rheumatic diseases (CRD), and clinicians, in the Asia-Pacific (APAC) region are reported.

Methods
Online surveys were completed by women, pregnant in the past 2–5 years, with moderate to severe rheumatoid arthritis (RA), psoriatic arthritis (PsA), axial spondyloarthritis (axSpA), and rheumatologists, obstetricians, orthopaedic surgeons who medically manage CRDs.

Results
Among 210 (RA 122, PsA 48, axSpA 40) patients, 52% (n = 109/210) delayed their decision to have children, most commonly due to concerns of passing on disease to offspring. 33% (n = 70/210) discussed family planning with a healthcare professional at diagnosis. Patients most often initiated discussions. 94% (n = 193/205) stopped treatment around pregnancy due to fear of fetal harm. 66% (n = 139/210) of patients felt they did not receive all relevant information on the impact of CRDs and treatment on pregnancy.
Among 335 clinicians who participated, 82% (n = 143/174) of rheumatologists, 86% (n = 72/84) of obstetricians and 43% (n = 33/77) of orthopaedic surgeons agreed good disease control during pregnancy was their primary goal. 69% (n = 120/174) of rheumatologists were ‘very comfortable’ with prescribing tumour necrosis factor inhibitors (TNFi) for women aged 18–45 years. Comfort levels generally decreased with the onset of family planning. More obstetricians and orthopaedic surgeons supported avoiding TNFi during pregnancy than rheumatologists (40% [n = 34/84]/38% [n = 29/77] versus 16% [n = 28/174]). Access to more TNFi safety data during pregnancy was considered paramount for increasing clinician comfort.

Conclusions
Patients and physicians need current information and multidisciplinary discussions for improved management of CRD in women in APAC.
Gripping performance in the stick insect Sungaya inexpectata in dependence on the pretarsal architecture
Authors: Winand Julian , Gorb Stanislav N. , Büscher Thies H. 
Published: September 2022

Abstract
Insect attachment devices and capabilities have been subject to research efforts for decades, and even though during that time considerable progress has been made, numerous questions remain. Different types of attachment devices are known, alongside most of their working principles, however, some details have yet to be understood. For instance, it is not clear why insects for the most part developed pairs of claws, instead of either three or a single one. In this paper, we investigated the gripping forces generated by the stick insect Sungaya inexpectata, in dependence on the number of available claws. The gripping force experiments were carried out on multiple, standardized substrates of known roughness, and conducted in directions both perpendicular and parallel to the substrate. This was repeated two times: first with a single claw being amputated from each of the animals’ legs, then with both claws removed, prior to the measurement. The adhesive pads (arolia) and frictional pads (euplantulae) remained intact. It was discovered that the removal of claws had a detractive effect on the gripping forces in both directions, and on all substrates. Notably, this also included the control of smooth surfaces on which the claws were unable to find any asperities to grip on. The results show that there is a direct connection between the adhesive performance of the distal adhesive pad (arolium) and the presence of intact claws. These observations show collective effects between different attachment devices that work in concert during locomotion, and grant insight into why most insects possess two claws.
Expect the unexpected: a case of spontaneous thrombosis of a pial arteriovenous fistula in a preterm newborn with review of the literature
Authors: Sabrina Congedi , Laura Moschino , Sabrina Salvadori , Giacomo Talenti , Nicoletta Mainini , Elena Priante , Francesco Causin , Eugenio Baraldi 
Published: September 2022

Abstract
Introduction
Pial arteriovenous fistulas (pAVF) are rare vascular malformations, especially in children and newborns. In neonates, the most common symptom is congestive heart failure.

Case presentation
We report a case of an asymptomatic preterm newborn incidentally diagnosed with pAVF during a routine cranial ultrasound (cUS) on the third day of life. Cerebral magnetic resonance (MRI) confirmed the diagnosis. A wait-and-see approach was chosen by the multidisciplinary team. The cUS and the MRI on day 14 of life showed the spontaneous resolution of the lesion.

Conclusions
This case underlines the challenges in identifying pAVF in the first weeks of life and demonstrates a possible positive outcome for affected neonates.
The protective effect of low-dose minocycline on brain microvascular ultrastructure in a rodent model of subarachnoid hemorrhage
Authors: Gendosz de Carrillo Daria , Student Sebastian , Bula Daniel , Mielańczyk Łukasz , Burek Małgorzata , Meybohm Patrick , Jędrzejowska-Szypułka Halina 
Published: September 2022

AbstractThe multifaceted nature of subarachnoid hemorrhage (SAH) pathogenesis is poorly understood. To date, no pharmacological agent has been found to be efficacious for the prevention of brain injury when used for acute SAH intervention. This study was undertaken to evaluate the beneficial effects of low-dose neuroprotective agent minocycline on brain microvascular ultrastructures that have not been studied in detail. We studied SAH brain injury using an in vivo prechiasmatic subarachnoid hemorrhage rodent model. We analyzed the qualitative and quantitative ultrastructural morphology of capillaries and surrounding neuropil in the rodent brains with SAH and/or minocycline administration. Here, we report that low-dose minocycline (1 mg/kg) displayed protective effects on capillaries and surrounding cells from significant SAH-induced changes. Ultrastructural morphology analysis revealed also that minocycline stopped endothelial cells from abnormal production of vacuoles and vesicles that compromise blood–brain barrier (BBB) transcellular transport. The reported ultrastructural abnormalities as well as neuroprotective effects of minocycline during SAH were not directly mediated by inhibition of MMP-2, MMP-9, or EMMPRIN. However, SAH brain tissue treated with minocycline was protected from development of other morphological features associated with oxidative stress and the presence of immune cells in the perivascular space. These data advance the knowledge on the effect of SAH on brain tissue ultrastructure in an SAH rodent model and the neuroprotective effect of minocycline when administered in low doses.
Sensory processing sensitivity and axonal microarchitecture: identifying brain structural characteristics for behavior
Authors: David Szabolcs , Brown Lucy L. , Heemskerk Anneriet M. , Aron Elaine , Leemans Alexander , Aron Arthur 
Published: September 2022

AbstractPrevious research using functional MRI identified brain regions associated with sensory processing sensitivity (SPS), a proposed normal phenotype trait. To further validate SPS, to characterize it anatomically, and to test the usefulness in psychology of methodologies that assess axonal properties, the present study correlated SPS proxy questionnaire scores (adjusted for neuroticism) with diffusion tensor imaging (DTI) measures. Participants (n = 408) from the Human Connectome Project were studied. Voxelwise analysis showed that mean- and radial diffusivity correlated positively with SPS scores in the right and left subcallosal and anterior–ventral cingulum bundle, and the right forceps minor of the corpus callosum, all frontal cortex areas generally underlying emotion, motivation, and cognition. Further analyses showed correlations throughout medial frontal cortical regions in the right and left ventromedial prefrontal cortex, including the superior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate, and arcuate fasciculus. Fractional anisotropy was negatively correlated with SPS scores in white matter (WM) of the right premotor/motor/somatosensory/supramarginal gyrus regions. Region of interest (ROI) analysis showed small effect sizes (− 0.165 to 0.148) in WM of the precuneus and inferior frontal gyrus. Other ROI effects were found in the dorsal-, ventral visual pathways and primary auditory cortex. The results reveal that in a large group of participants, axonal microarchitectural differences can be identified with SPS traits that are subtle and in the range of typical behavior. The results suggest that the heightened sensory processing in people who show that SPS may be influenced by the microstructure of WM in specific cortical regions. Although previous fMRI studies had identified most of these areas, the DTI results put a new focus on brain areas related to attention and cognitive flexibility, empathy, emotion, and first levels of sensory processing, as in primary auditory cortex. Psychological trait characterization may benefit from DTI methodology by identifying influential brain systems for traits.
Characteristics and outcome of patients with small bowel adenocarcinoma (SBA)
Authors: Teufel Andreas , Meindl-Beinker Nadja M. , Hösel Pauline , Gerken Michael , Roig Ana , Ebert Matthias P. , Herr Wolfgang , Scheiter Alexander , Pauer Armin , Schlitt Hans J. , Klinkhammer-Schalke Monika 
Published: September 2022

Abstract
Background
Small bowel adenocarcinoma (SBA) remains a rare malignancy accounting for less than 5% of all the gastrointestinal tract cancers. However, only limited data and expert guidelines are available for this entity. As a result, treatment concepts are predominantly derived from colorectal cancer.

Methods
To substantiate data on the course of disease, diagnosis and treatment of SBA, we performed a population-based analysis from a Bavarian population of 2.2 million people.

Results
We identified 223 patients with SBA. Mean age at diagnosis was 67.8 years and patients were diagnosed rather late (34.5% UICC stage IV). Largest proportion of these patients were diagnosed with adenocarcinoma of the duodenum (132 patients, 59.2%) and most patients were diagnosed with late stage cancer, stage IV (70 patients, 31.4%). With respect to treatment, most patients underwent primary surgery (187 patients, 84.6%). Systemic therapy seemed to have an impact in UICC stage IV patients but not in UICC stage IIB or III. The 5-year survival rate was 29.0%. This was significantly less compared to colon cancer in the same cohort, which was 50.0%. Furthermore, median survival of patients with small bowel cancer was only 2.0 years (95% CI 1.4–2.5) compared to 4.9 years (95% CI 4.8–5.1) of patients with colon cancer.

Conclusion
SBA showed a distinct epidemiology compared to colon cancer. Thus, data acquisition particularly on systemic treatment are paramount, with the objective to complement the available guidelines.
Kalmbach measurability in D-lattices
Authors: Avallone Anna , Vitolo Paolo 
Published: September 2022

AbstractWe extend to D-lattices the definition of Kalmbach measurable elements with respect to an outer measure $$\mu $$
μ
. We prove, in case $$\mu $$
μ
is faithful, that Kalmbach measurable elements are central, thus generalizing a result known for orthomodular lattices.
The Humboldtian Model of Higher Education and its Significance for the European University on Responsible Consumption and Production
Authors: Bongaerts Jan C. 
Published: September 2022

AbstractThis contribution describes the origins and essential characteristics of the Humboldtian Model of Higher Education. It also shows how this model can be integrated into the European University on Responsible Consumption and Production (EURECA-PRO). Wilhelm von Humboldt and his team developed the innovative Humboldtian Model of Higher Education in Humboldt’s native Prussia between 1809 and 1810 in order to totally reform the education system. After founding the University of Berlin in 1810 and with the support of leading young scientists cum professors, Humboldt intended to implement this new model of tertiary education. The Humboldtian Model requires that universities govern themselves, have academic freedom, and integrate education and research. As a consequence, science is unified and all academic disciplines are present within a given university. This model also calls for university-wide interaction and for all university members to communicate such that students become integrated as researching learners and learning researchers through close co-operation with their teachers. With the emergence of the neoliberal university model in the 1990s, key elements of the Humboldtian Model have been complemented by university obligations to meet expectations from government, the business community, and society at large with regard to the usefulness and benefit of university research and educational outputs. This contribution concludes by discussing the potential of implementing the Humboldtian Model of Higher Education within EURECA-PRO.