bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered somatosensory functioning and mechanism‐based classification in breast cancer patients with persistent pain
Authors: Haenen Vincent , Dams Lore , Meeus Mira , De Groef An 
Published: November 2022

AbstractPain is one of the most frequent and persistent side effects of breast cancer treatment. Besides pain, breast cancer survivors (BCS) are prone to experience a myriad of other signs and symptoms related to altered somatosensory function, including for example, hypoesthesia, allodynia, and hyperalgesia, both at the local site of cancer and in remote body parts. Different breast cancer treatments can have a direct effect on somatosensory functioning, resulting in a wide range of these signs and symptoms. To our knowledge, currently no comprehensive overview exists on altered somatosensory functioning and resulting signs and symptoms in BCS with persistent pain. Investigating altered somatosensory functioning in this population could provide more insights in the underpinning pathophysiological mechanisms and consequently improve prevention and treatment in the future. Therefore, in this paper, first, normal somatosensory functioning is described. Second, quantitative sensory testing is presented as the recommend method to evaluate somatosensory functioning. Third, existing evidence on altered somatosensory functioning in BCS with persistent pain is summarized. Altered somatosensory functioning related to the most common cancer treatment modalities, including surgery and radiotherapy, hormone therapy, and chemotherapy are discussed. In addition, evidence on the presence of nociplastic pain as pain resulting from altered somatosensory functioning without evidence for nociception and/or neuropathy in BCS is summarized. At last, a discussion on this available evidence, limitations, and perspectives for clinical practice and for research are made.
Catalytic Mechanisms of Transfer Hydrogenation of Azobenzene with Ammonia Borane by Pincer Bismuth Complex: Crucial Role of C=N Functional Group on the Pincer Ligand
Authors: Zhu Qin , Zhang Shuoqi , Ma Jing , Zhu Jun , Li Shuhua , Zeng Guixiang 
Published: November 2022

AbstractTransfer hydrogenation of azobenzene with ammonia borane mediated by pincer bismuth complex 1 was systematically investigated through density functional theory calculations. An unusual metal‐ligand cooperation mechanism was disclosed, in which the saturation/regeneration of the C=N functional group on the pincer ligand plays an essential role. The reaction is initiated by the hydrogenation of the C=N bond (saturation) with ammonia borane to afford 3CN, which is the rate‐determining step with Gibbs energy barrier (ΔG≠) and Gibbs reaction energy (ΔG) of 25.6 and −7.3 kcal/mol, respectively. 3CN is then converted to a Bi−H intermediate through a water‐bridged pathway, which is followed up with the transfer hydrogenation of azobenzene to produce the final product N,N′‐diphenylhydrazine and regenerate the catalyst. Finally, the catalyst could be improved by substituting the phenyl group for the tert‐butyl group on the pincer ligand, where the ΔG≠ value (rate‐determining step) decreases to 24.0 kcal/mol.
Computed tomography‐based radiomics prediction of CTLA4 expression and prognosis in clear cell renal cell carcinoma
Authors: He Hongchao , Jin Zhijia , Dai Jun , Wang Haofei , Sun Jianqi , Xu Danfeng 
Published: November 2022

AbstractObjectivesTo predict CTLA4 expression levels and prognosis of clear cell renal cell carcinoma (ccRCC) by constructing a computed tomography‐based radiomics model and establishing a nomogram using clinicopathologic factors.MethodsThe clinicopathologic parameters and genomic data were extracted from 493 ccRCC cases of the Cancer Genome Atlas (TCGA)‐KIRC database. Univariate and multivariate Cox regression and Kaplan–Meier analysis were performed for prognosis analysis. Cibersortx was applied to evaluate the immune cell composition. Radiomic features were extracted from the TCGA/the Cancer Imaging Archive (TCIA) (n = 102) datasets. The support vector machine (SVM) was employed to establish the radiomics signature for predicting CTLA4 expression. Receiver operating characteristic curve (ROC), decision curve analysis (DCA), and precision‐recall curve were utilized to assess the predictive performance of the radiomics signature. Correlations between radiomics score (RS) and selected features were also evaluated. An RS‐based nomogram was constructed to predict prognosis.ResultsCTLA4 was significantly overexpressed in ccRCC tissues and was related to lower overall survival. A higher CTLA4 expression was independently linked to the poor prognosis (HR = 1.458, 95% CI 1.13–1.881, p = 0.004). The radiomics model for the prediction of CTLA4 expression levels (AUC = 0.769 in the training set, AUC = 0.724 in the validation set) was established using seven radiomic features. A significant elevation in infiltrating M2 macrophages was observed in the RS high group (p < 0.001). The predictive efficiencies of the RS‐based nomogram measured by AUC were 0.826 at 12 months, 0.805 at 36 months, and 0.76 at 60 months.ConclusionsCTLA4 mRNA expression status in ccRCC could be predicted noninvasively using a radiomics model based on nephrographic phase contrast‐enhanced CT images. The nomogram established by combining RS and clinicopathologic factors could predict overall survival for ccRCC patients. Our findings may help stratify prognosis of ccRCC patients and identify those who may respond best to ICI‐based treatments.
Sewage Sludge Activated Carbon as an Adsorbent and Catalytic Support: Evaluation of Nitrate Removal and Suzuki‐Miyaura Cross‐Coupling
Authors: Rosa Clarissa H. , Schmitt Cristiane R. , Fonseca Cecilia S. , dos Santos João Henrique Z. , Lopes Toni J. , Rosa Gilber R. 
Published: November 2022

AbstractThis manuscript reports the valorization of sewage sludge with the production of activated carbon. Thus, a series of 11 adsorbents are produced, activated with different substances (salt, acid, and base), and their adsorptive properties are carefully evaluated. The C6 series of activated carbons prove to be very efficient for removing nitrate anions from aqueous medium and, due to this, it is evaluated as a catalytic support for palladium nanoparticles. The generated solid, named Pd@CA6F, is the first report of a catalyst containing activated carbon from sewage sludge that is efficient in the Suzuki‐Miyaura cross‐coupling. The catalytic system developed is eco‐friendly, phosphine‐free, and of low cost. Good yields are obtained in the coupling of aryl iodides with phenylboronic acid in a short time. The same catalyst load could be recycled for up to ten times.
Real‐world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities
Authors: Sousa‐Pinto Bernardo , Anto Aram , Berger Markus , Dramburg Stephanie , Pfaar Oliver , Klimek Ludger , Jutel Marek , Czarlewski Wienczyslawa , Bedbrook Anna , Valiulis Arunas , Agache Ioana , Amaral Rita , Ansotegui Ignacio J. , Bastl Katharina , Berger Uwe , Bergmann Karl C. , Bosnic‐Anticevich Sinthia , Braido Fulvio , Brussino Luisa , Cardona Victoria , Casale Thomas , Canonica G. Walter , Cecchi Lorenzo , Charpin Denis , Chivato Tomás , Chu Derek K. , Cingi Cemal , Costa Elisio M. , Cruz Alvaro A. , Devillier Philippe , Durham Stephen R. , Ebisawa Motohiro , Fiocchi Alessandro , Fokkens Wytske J. , Gemicioğlu Bilun , Gotua Maia , Guzmán Maria‐Antonieta , Haahtela Tari , Ivancevich Juan Carlos , Kuna Piotr , Kaidashev Igor , Khaitov Musa , Kvedariene Violeta , Larenas‐Linnemann Désirée E. , Lipworth Brian , Laune Daniel , Matricardi Paolo M. , Morais‐Almeida Mario , Mullol Joaquim , Naclerio Robert , Neffen Hugo , Nekam Kristoff , Niedoszytko Marek , Okamoto Yoshitaka , Papadopoulos Nikolaos G. , Park Hae‐Sim , Passalacqua Giovanni , Patella Vincenzo , Pelosi Simone , Pham‐Thi Nhân , Popov Ted A. , Regateiro Frederico S. , Reitsma Sietze , Rodriguez‐Gonzales Monica , Rosario Nelson , Rouadi Philip W. , Samolinski Boleslaw , Sá‐Sousa Ana , Sastre Joaquin , Sheikh Aziz , Ulrik Charlotte Suppli , Taborda‐Barata Luis , Todo‐Bom Ana , Tomazic Peter Valentin , Toppila‐Salmi Sanna , Tripodi Salvatore , Tsiligianni Ioanna , Valovirta Erkka , Ventura Maria Teresa , Valero Antonio A. , Vieira Rafael José , Wallace Dana , Waserman Susan , Williams Sian , Yorgancioglu Arzu , Zhang Luo , Zidarn Mihaela , Zuberbier Jaron , Olze Heidi , Antó Josep M. , Zuberbier Torsten , Fonseca João A. , Bousquet Jean 
Published: November 2022

AbstractDigital health is an umbrella term which encompasses eHealth and benefits from areas such as advanced computer sciences. eHealth includes mHealth apps, which offer the potential to redesign aspects of healthcare delivery. The capacity of apps to collect large amounts of longitudinal, real‐time, real‐world data enables the progression of biomedical knowledge. Apps for rhinitis and rhinosinusitis were searched for in the Google Play and Apple App stores, via an automatic market research tool recently developed using JavaScript. Over 1500 apps for allergic rhinitis and rhinosinusitis were identified, some dealing with multimorbidity. However, only six apps for rhinitis (AirRater, AllergyMonitor, AllerSearch, Husteblume, MASK‐air and Pollen App) and one for rhinosinusitis (Galenus Health) have so far published results in the scientific literature. These apps were reviewed for their validation, discovery of novel allergy phenotypes, optimisation of identifying the pollen season, novel approaches in diagnosis and management (pharmacotherapy and allergen immunotherapy) as well as adherence to treatment. Published evidence demonstrates the potential of mobile health apps to advance in the characterisation, diagnosis and management of rhinitis and rhinosinusitis patients.
A hierarchical decentralized architecture to enable adaptive scalable virtual machine migration
Authors: Hummaida Abdul R. , Paton Norman W. , Sakellariou Rizos 
Published: November 2022

AbstractCloud computing is an established paradigm for end users to access resources. Cloud infrastructure providers seek to maximize accepted requests, meet Service Level Agreements (SLAs), and reduce operational costs by dynamically allocating Virtual Machines (VMs) to physical nodes. Many solutions have been presented to manage cloud infrastructure, however, these tend to be centralized and suffer in their ability to maintain Quality of Service (QOS) and support data centers with thousands of nodes. Decentralized approaches, with no central management, can manage large data centers. However, these tend to reduce the ability to obtain an optimal resource allocation across the data center. To address this, we propose a hybrid hierarchical decentralized architecture that achieves lower SLA violations and lowers network traffic. We used simulation to evaluate our proposal in practice with a variety of existing VM placement policies.
Acquisition method of target leveling height based on machine vision
Authors: Yin Qiang , Gu JiaXin , Song Shaoyun , Zhang Yonglin , Zhao Gang , Hao ZhiQiang 
Published: November 2022

SummaryGrain leveling robot is a special equipment to realize grain surface leveling in granary. Whether the target height of grain leveling is clear or not has a great influence on the leveling effect and efficiency of grain surface. In this article, the deficiencies of existing grain leveling robots are summarized, and a method of obtaining target leveling height based on machine vision is proposed. Data were collected by RGB‐D camera, the depth matrix of the whole large granary was obtained by image stitching and edge detection, and then the target height of the grain leveling robot was obtained by the element method. It solves the problem of controlling the falling height of the robot by human subjective feeling, improves the efficiency and precision of the robot, optimizes the effect of the robot, and helps to realize the intelligent work of the robot.
Effect of Li Doping on Cu2SnS3/n‐Si Heterojunction Solar Cells: Experiments and Simulation
Authors: Houimi Amina , Gezgin Serap Yiğit , Mercimek Bedrettin , Kiliç Hamdi Şükür 
Published: November 2022

AbstractCu2SnS3(CTS) semiconductor material owns very interesting absorbing properties that allow it to be effectively utilized in many thin‐film‐based heterojunction solar cells. In this work, using the ball milling method, a mixture of pure elemental powders is used to synthesize CTS material. Homemade undoped and Li‐doped target pellets are used to form CTS‐doped and CTS‐undoped thin films. The crystallinity investigation of synthesized targets and thin films confirms the formation of CTS tetragonal phase. Compositional, morphologic, and optic studies are also made to examine the effect of Li atom incorporation on different properties of CTS thin films. These CTS thin films are also incorporated into heterojunction solar cells (Al/n‐Si/CTS/Ag and Al/n‐Si/Li0.03CTS/Ag). In addition,J–Vcharacteristics of both CTS and Li0.03CTS solar cells are demonstrated and discussed in details. The effect of CTS thin films' thickness on the performance is studied using Solar Cell Capacitance Simulator (SCAPS‐1D) program. The results of the calculation are discussed in details and compared with the experimental results. An increase in efficiency is achieved in solar cells based on Li‐doped CTS thin films, and it is discussed in detail along with SCAPS‐1D simulation that is carried out depending on the thickness of CTS thin films.
Sealing ability in vitro study and biocompatibility in vivo animal study of different bioceramic based sealers
Authors: Haji Tara H. , Selivany Bahar J. , Suliman Abdulhaq A. 
Published: November 2022

AbstractIntroductionThe effectiveness of root canal therapy in endodontic practice is largely determined by providing a compact fluid‐tight closure at the apex of the root canal, which inhibits irritant entry and buildup, which leads to a biological breakdown of the attachment mechanism and failure. During obturation, along with gutta‐percha, root canal sealers are employed to fill voids and seal root canals. Root canal sealers come in a variety of shapes and sizes, each with its own set.AimEvaluation of sealing ability in vitro study by using scanning electron microscopy (SEM) and biocompatibility in vivo animals study of BioRoot RCS and meta Biomed bio_ceramic sealer (CeraSeal RCS) and compared the findings with that of Zinc oxide eugenol (ZOE) sealer as control.Materials and MethodsThis study utilized two bio_ceramic sealers (BioRoot RCS and meta Biomed bio_ceramic sealer (CeraSeal RCS) and compared the findings with that of ZOE sealer as control. Biocompatibility was determined by examining histopathological biopsy specimens collected from rabbits. Each rabbit had four dentin tubes implanted into the subcutaneous tissues, one for BioRoot RCS, one for CeraSeal RCS, and one for ZOE RCS, with the fourth tube being empty haematoxylin and eosin were used to stain histological sections, and a light microscope was used to evaluate them. Extracted human single canal premolars were used to evaluate the sealing ability. The root canals were divided into three sections (coronal, middle, and apical). SEM was used to assess the adhesion quality at the sealer‐dentin interface.ResultsBioRoot and CeraSeal sealers have excellent sealing adaptation and biocompatibility, as well as rapid tissue recovery, while ZOE sealers have a slower recovery of inflammatory reaction results when compared to bio_root and ceraSeal sealers, as well as a less sealing adaptation than the two other bio_ceramic sealers.ConclusionIn general, the two bioceramic sealers tested were biocompatible and capable of sealing or adhesion. While ZOE had less adherence ability and less biocompatibility.
Corporate social responsibility and circular economy from the perspective of consumers: A cross‐cultural analysis in the cosmetic industry
Authors: Kolling Camila , Ribeiro José Luis Duarte , Morea Donato , Iazzolino Gianpaolo 
Published: November 2022

AbstractCorporate social responsibility (CSR) and circular economy (CE) have assumed considerable importance in the efforts for sustainable development. However, some consumers do not positively respond to CSR and CE activities, and few studies have analyzed the consumers' perspective about the topics. This study investigates consumer knowledge and perception about CSR and CE and their willingness to pay (WTP) for products from companies that follow these concepts, examining differences according to demographic characteristics. We carried out a survey with 302 Brazilian and Italian consumers of cosmetic products. Our results show that most consumers have a low understanding of CSR and CE and a low perception of the socio‐environmental initiatives of companies that follow CSR and CE concepts. Nevertheless, most consumers show WTP for products from companies that follow these concepts. We identified demographic variables that allowed us to relate the profile of consumers with their knowledge about CSR and CE and their WTP. We provide insights for companies and policymakers in advancing toward CSR and CE.
Tuning the Carrier Transfer Behavior of Coaxial ZnO/ZnS/ZnIn2S4 Nanorods with a Coherent Lattice Heterojunction Structure for Photoelectrochemical Water Oxidation
Authors: Peng Jing , Liu Guorui , Jiao Xianhui , Xia Hongqiang , Li Jing , Ma Qingxiang , Jin Jun , Li Feng 
Published: November 2022

AbstractInvited for this month′s cover is the group of Feng Li at the Ningxia University. The image shows how the coherent lattice heterojunction interface can play a role in the efficient separation of photogenerated carriers of ZnO‐based photoanode for photoelectrochemical water splitting. The Research Article itself is available at 10.1002/cssc.202201469.
Evaluation, design, and test of single switch high step‐up boost converter with autotransformer
Authors: Andrade António Manuel Santos Spencer , Faistel Tiago Miguel Klein , Guisso Ronaldo Antonio 
Published: November 2022

SummaryIn this article, different autotransformer structures are discussed, demonstrating their connection and voltage gain characteristics. In this sense, an autotransformer structure was chosen that presents a high voltage gain with a low transformation ratio (N), thus seeking to reduce the leakage inductance and volume. From there, this structure is integrated into the isolated boost converter, thus generating a new high step‐up DC‐DC topology. The proposed converter presents as main characteristics: high voltage gain, low voltage stress on the components, continuous input current, low number of components, simplicity of operation and control, and high efficiency. To validate the theoretical evaluations, a 200 W, 30 V/400 V prototype was built in the laboratory, achieving a maximum efficiency of 96.25%.
The geographic footprint of mutualism: How mutualists influence species' range limits
Authors: Fowler Joshua C. , Donald Marion L. , Bronstein Judith L. , Miller Tom E. X. 
Published: November 2022

AbstractUnderstanding mechanisms that generate range limits is central to knowing why species are found where they are and how they will respond to environmental change. There is growing awareness that biotic interactions play an important role in generating range limits. However, current theory and data overwhelmingly focus on abiotic drivers and antagonistic interactions. Here we explore the effect that mutualists have on their partner's range limits: the geographic “footprint” of mutualism. This footprint arises from two general processes: modification of a partner's niche through environment‐dependent fitness effects and, for a subset of mutualisms, dispersal opportunities that lead suitable habitats to be filled. We developed a conceptual framework that organizes different footprints of mutualism and the underlying mechanisms that shape them, and evaluated supporting empirical evidence from the primary literature. In the available literature, we found that the fitness benefits and dispersal opportunities provided by mutualism can extend species' ranges; conversely, the absence of mutualism can constrain species from otherwise suitable regions of their range. Most studies found that the footprint of mutualism is driven by changes in the frequency of mutualist partners from range core to range edge, whereas fewer found changes in interaction outcomes, the diversity of partners, or varying sensitivities of fitness to the effects of mutualists. We discuss these findings with respect to specialization, dependence, and intimacy of mutualism. Much remains unknown about the geographic footprint of mutualisms, leaving fruitful areas for future work. A particularly important future direction is to explore the role of mutualism during range shifts under global change, including the promotion of shifts at leading edges and persistence at trailing edges.
New Water‐Soluble Au(III) Complexes with Xyloside‐Based Ligands: Synthesis, Structural Characterization, Solution Studies and Catalytic Evaluation
Authors: Pascual Laura M. H. , Boudesocque Stéphanie , Dupont Laurent , Hénon Eric , Mohamadou Aminou , Plantier‐Royon Richard , Gatard Sylvain 
Published: November 2022

AbstractA short and convenient approach to the original xyloside‐based ligands, has been achieved, usingd‐xylose as a starting material. The complexation properties of these ligands towards Au(III) cations were studied by different methods, such as multinuclear NMR, mass spectrometry, elemental analysis. A preliminary study using protometric titrations has been carried out in aqueous solution under various pH conditions, thus in order to investigate the binding of Au(III) cations to these ligands. Furthermore, molecular calculations were performed to obtain additional structural information. The catalytic activity of the most stable Au(III) complexes was evaluated for the homogeneous reduction of 4‐nitrophenol (4‐NP) to 4‐aminophenol (4‐AP) in the presence of NaBH4.
Experience with the ketogenic diet in premature neonates
Authors: Phitsanuwong Chalongchai , Kim Jeong‐A , Schimpf Stephanie , Nordli Douglas R. 
Published: November 2022

AbstractThe ketogenic diet is a time‐tested, potent, nonpharmacological treatment of epilepsy. However, the use of the ketogenic diet in premature neonates with epilepsy has not been previously reported. We share our experience with the use of ketogenic diet therapy in two premature neonates. Two identical twin premature neonates with SCN2A‐related developmental and epileptic encephalopathy, whose seizures were refractory to multiple anti‐seizure medications, were started on the classic ketogenic diet at the conceptual age of 35 weeks. Ketosis was achieved and maintained (range 2‐5 mmol/L of serum beta‐hydroxybutyrate level). Seizure frequency was significantly reduced (>90% reduction in both patients), and some anti‐seizure medications were able to be discontinued. Initial transient weight loss and one episode of asymptomatic hypoglycemia were observed and corrected. The ketogenic diet was found to be a safe, well‐tolerated, and effective treatment for seizures in two premature neonates. The side effects are tolerable and correctable. The ketogenic diet, therefore, is a treatment option for refractory seizures in this age group, when administered under expert guidance.