bluuebunny/crossref_metadata_2025_split huggingface dataset:
МОРФОФУНКЦІОНАЛЬНІ ЗМІНИ ЯЄЧНИКІВ ЩУРІВ ПІД ВПЛИВОМ АЦЕТАТУ СВИНЦЮ В ЕКСПЕРИМЕНТІ
Authors: Білик Я. О. , Чорній С. В. , Денефіль О. В. , Федонюк Л. Я. , Терлецька Н. Ю. 
Published: March 2022

Вступ. Свинець є природним токсичним металом, який міститься в земній корі. Як токсикант він перебуває в центрі уваги не лише екологів, токсикологів і гігієністів, а й морфологів та клініцистів. Це зумовлено тим, що отруєння сполуками свинцю супроводжуються порушенням функціонування нервової, серцево-судинної, травної, сечовидільної та репродуктивної систем.
Мета дослідження – вивчити вплив малих, середніх і великих доз ацетату свинцю на біохімічні показники та морфологічний стан яєчників щурів в експерименті.
Методи дослідження. Дослідження виконано на 40 статевозрілих нелінійних щурах-самицях, розділених на 4 експериментальні групи, яким упродовж 30 днів давали для пиття розчин ацетату свинцю з розрахунку 0,05, 10 та 60 мг/кг маси тварини. У роботі використано біохімічні, гістологічні й статистичний методи дослідження.
Результати й обговорення. Встановлено, що у 3-й групі тварин, порівняно з 2-ю, концентрація діє­нових кон’югатів (ДК) була вищою у 2,8 раза, ТБК-активних продуктів (ТБК-ап) – у 2,1 раза. У 4-й групі щурів, порівняно з 2-ю, вміст ДК був більшим у 4,3 раза, ТБК-ап – у 2,7 раза. У 4-й групі тварин, порівняно з 3-ю, рівень ДК був вищим на 55,8 %, ТБК-ап – на 24,8 %. У 3-й групі щурів, порівняно з 2-ю, супероксиддисмутазна (СОД) активність була меншою на 34,7 %, а каталазна (КАТ) – більшою на 32,3 %. У 4-й групі тварин, порівняно з 2-ю, СОД активність була нижчою на 63 %, а КАТ активність – на 86,6 %. У 4-й групі щурів, порівняно з 3-ю, СОД активність була меншою на 43,3 %, а КАТ активність – на 89,9 %. Результати проведених морфологічних досліджень яєчників у тварин усіх груп показали, що з наростанням дози ацетату свинцю поглиблювалися морфологічні зміни як у кірковій, так і у мозковій речовинах яєчників щурів. Це призводило до зміни товщини поверхневих структур яєчників та зменшення кількості фолікулів, що свідчило про порушення процесів їх росту і дозрівання.
Висновок. При впливі малих доз ацетату свинцю зміни мають адаптаційно-компенсаторний характер, а при дії великих – дистрофічно-деструктивний.
РОЗРОБКА СПЕКТРОФОТОМЕТРИЧНОЇ МЕТОДИКИ ВИЗНАЧЕННЯ АТОРВАСТАТИНУ В ТАБЛЕТКАХ
Authors: Шуляк Н. С. , Процик C. А. , Кучер Т. В. , Криськів Л. С. 
Published: March 2022

Вступ. Аторвастатин – широко представлений на фармацевтичному ринку України гіполіпідемічний засіб, який використовують при гіперліпідемії та для профілактики захворювань серцево-судинної системи. Відомо багато методик кількісного визначення аторвастатину, однак багато з них має обмежене застосування через використання шкідливих реагентів, довготривалість, нагрівання, необхідність екстракції тощо.
Мета дослідження – розробити з дотриманням принципів “зеленої” хімії просту економічно ефективну УФ-спектрофотометричну методику визначення аторвастатину в лікарських засобах, які представлено на ринку України.
Методи дослідження. При виконанні цього дослідження застосовували спектрофотометр “Shimadzu UV-1800” (Японія), ваги лабораторні електронні “RAD WAG AS 200/C”, ультразвукову баню “Sonorex Digitec DT100H”, мірний посуд класу А, фармакопейний стандартний зразок аторвастатину кальцію тригідрат (“Sigma-Aldrich”, ≥98 %, HPLC), метанол Р (“Honeywell Riedel-de Haen™”, 99,9 %), таблетки “Аторвастатин-Teвa”, 10 мг № 10 (“Teva”, Ізраїль), серія № 19939.
Результати й обговорення. Для опрацювання методики кількісного визначення аторвастатину методом прямої УФ-спектрофотометрії було обрано інтенсивно виражений максимум поглинання препарату при довжині хвилі 247 нм. Шляхом прогнозування повної невизначеності аналітичної методики підтверджено її коректність (2,56 %). Лінійну залежність отримано в діапазоні 8–40 мкг/мл, межа виявлення та межа кількісного визначення становили 0,5 і 1,6 мкг/мл відповідно. Специфічність методики доведено відсутністю смуг поглинання при аналітичній довжині хвилі у розчинів плацебо аналізованих таблеток. Прецизійність експериментальних результатів характеризувалася низьким стандартним відхиленням у досліджуваному діапазоні концентрацій активного фармацевтичного інгредієнта (RSD=3,1 %), а систематична похибка була на рівні 0,02 %. При вивченні робасності методики встановлено стабільність поглинання розчинів у часі впродовж 100 хв. За аналітичною еко-шкалою методика є “Відмінним “зеленим” аналізом”.
Висновки. Розроблено методику УФ-спектрофотометричного визначення кількісного вмісту аторвастатину в таблетках (λmax=247 нм). Розраховано повну невизначеність розробленої методики. За такими валідаційними характеристиками, як лінійність, прецизійність, правильність та робасність, методика є коректною.
Combining Minimally Invasive Surgery With Ultra-Fast-Track Anesthesia in HeartMate 3 Patients: A Pilot Study
Authors: Ahmad Usaama , Khattab Mohammad Amen , Schaelte Gereon , Goetzenich Andreas , Foldenauer Ann C. , Moza Ajay , Tewarie Lachmandath , Stoppe Christian , Autschbach Rüdiger , Schnoering Heike , Zayat Rashad 
Published: March 2022

Background:
Minimally invasive surgery for left ventricular assist device implantation may have advantages over conventional sternotomy (CS). Additionally, ultra-fast-track anesthesia has been linked to better outcomes after cardiac surgery. This study summarizes our early experience of combining minimally invasive surgery with ultra-fast-track anesthesia (MIFTA) in patients receiving HeartMate 3 devices and compares the outcomes between MIFTA and CS.

Methods:
From October 2015 to January 2019, 18 of 49 patients with Interagency Registry for Mechanically Assisted Circulatory Support profiles >1 underwent MIFTA for HeartMate 3 implantation. For bias reduction, propensity scores were calculated and used as a covariate in a regression model to analyze outcomes. Weighted parametric survival analysis was performed.

Results:

In the MIFTA group, intensive care unit stays were shorter (mean difference, 8 days [95% CI, 4–13];
P
<0.001), and the incidences of pneumonia and right heart failure were lower than those in the CS group (odds ratio, 1.36 [95% CI, 1.01–1.75];
P
=0.016, respectively). At 6 and 12 hours postoperatively, MIFTA patients had a better hemodynamic performance with lower pulmonary wedge pressure (mean difference, 2.23 mm Hg [95% CI, 0.41–4.06];
P
=0.028) and a higher right ventricular stroke work index (mean difference, −1.49 g·m/m
2
per beat [95% CI, −2.95 to −0.02];
P
=0.031). CS patients had a worse right heart failure–free survival rate (hazard ratio, 2.35 [95% CI, 0.96–5.72];
P
<0.01).

Conclusions:
Compared with CS, MIFTA is a beneficial approach for non–Interagency Registry for Mechanically Assisted Circulatory Support 1 HeartMate 3 patients with lower adverse event incidences, better hemodynamic performance, and preserved right heart function. Future large multicentric investigations are required to verify MIFTA’s effects on outcomes.
Children’s cookbooks – Learning by using recipes, cooking experiments and taste competence
Authors: Christensen Jacob Højgaard , Wistoft Karen 
Published: March 2022

Introduction: My Cookery is a children’s cookery book that aims to enhance children’s joy of cooking and develop their cooking skills. It has been distributed to more than 450,000 children in Denmark. The development of the book was infomed by research into food education approaches that are generally known to enhance student outcomes (experiential learning, co-determination and activating taste competences). This article reports on a study which aimed to investigate the effectiveness of the different approaches students use to engage with the cookery book. Method: A survey was conducted among students ( N = 1,609) with experience of using My Cookery. Outcomes were measured in terms of self-assessed learning. Different approaches to use were measured in terms of (1) how recipes were used, (2) whether taste competences were used actively, (3) students’ level of co-determination and (4) school, home and website use, respectively. Through multiple stepwise regression, correlations between student outcome and different methods of usage were analysed. Conclusion: The results indicate that the greatest effect was achieved when students used their taste competences actively. The second-largest effect was linked to students’ home usage. To carry out effective home economics teaching, it may be essential to facilitate processes that reach into the home and ensure taste competences are activated during cooking.
Sorting Insiders From Co-Workers: Remote Synchronous Computer-Mediated Triage for Investigating Insider Attacks
Authors: Dando Coral J. , Taylor Paul J. , Menacere Tarek , Ormerod Thomas C. , Ball Linden J. , Sandham Alexandra L. 
Published: March 2022

Objective Develop and investigate the potential of a remote, computer-mediated and synchronous text-based triage, which we refer to as InSort, for quickly highlighting persons of interest after an insider attack. Background Insiders maliciously exploit legitimate access to impair the confidentiality and integrity of organizations. The globalisation of organisations and advancement of information technology means employees are often dispersed across national and international sites, working around the clock, often remotely. Hence, investigating insider attacks is challenging. However, the cognitive demands associated with masking insider activity offer opportunities. Drawing on cognitive approaches to deception and understanding of deception-conveying features in textual responses, we developed InSort, a remote computer-mediated triage. Method During a 6-hour immersive simulation, participants worked in teams, examining password protected, security sensitive databases and exchanging information during an organized crime investigation. Twenty-five percent were covertly incentivized to act as an ‘insider’ by providing information to a provocateur. Results Responses to InSort questioning revealed insiders took longer to answer investigation relevant questions, provided impoverished responses, and their answers were less consistent with known evidence about their behaviours than co-workers. Conclusion Findings demonstrate InSort has potential to expedite information gathering and investigative processes following an insider attack. Application InSort is appropriate for application by non-specialist investigators and can be quickly altered as a function of both environment and event. InSort offers a clearly defined, well specified, approach for use across insider incidents, and highlights the potential of technology for supporting complex time critical investigations.
Prospective examination of the therapeutic role of psychological flexibility and cognitive reappraisal in the ceremonial use of ayahuasca
Authors: Agin-Liebes Gabrielle , Zeifman Richard , Luoma Jason B , Garland Eric L , Campbell W Keith , Weiss Brandon 
Published: March 2022

Background: Evidence suggests that psychedelic-assisted therapy carries transdiagnostic efficacy in the treatment of mental health conditions characterized by low mood and the use of avoidance coping strategies. Aims: While preliminary evidence suggests that psychological flexibility and emotion regulation processes play an important role within psychedelic therapy, this prospective study addressed methodological gaps in the literature and examined the ability of ayahuasca to stimulate acute states of cognitive reappraisal and long-term changes in psychological flexibility and mood. The study also explored whether moderating factors predisposed participants to experience therapeutic changes. Methods: Participants ( N = 261) were recruited from three Shipibo ayahuasca retreat centers in Central and South America and completed assessments on mood, psychological flexibility, and acute ceremonial factors. Expectancy, demand characteristics, and invalid responding were controlled for with several validity scales. Results/Outcomes: Participants reported significant reductions in negative mood after three months, as well as increases in positive mood and psychological flexibility. Acute experiences of reappraisal during the ayahuasca ceremony exerted the strongest moderating effects on increases in positive mood and psychological flexibility. Increases in psychological flexibility statistically mediated the effects of acute psychological factors, including reappraisal, on changes in positive mood. Conclusions/Interpretation: These results highlight the role of acute psychological processes, such as reappraisal, and post-acute increases in psychological flexibility as putative mechanisms underlying positive outcomes associated with psychedelics. These results also provide support for the integration of third-wave and mindfulness-based therapy approaches with psychedelic-assisted interventions.
Effectiveness of Nonoperative Management of Hip Microinstability
Authors: Ejnisman Leandro , Elisman Katerina , Safran Marc R. 
Published: March 2022

Background: Hip microinstability has recently gained acceptance as a cause of hip pain. In this condition, the femoral head demonstrates increased motion relative to the acetabulum, which may lead to chondrolabral damage. Even though patients are initially prescribed a trial of nonoperative treatment, the success rates of rehabilitation are unknown. Purpose: To determine the success rate of nonoperative treatment of hip microinstability. Study Design: Case series; Level of evidence, 4. Methods: After institutional review board approval was obtained, a retrospective chart review was performed on patients at a university sports medicine practice between January 2013 and July 2016. All patients older than 18 years presenting with hip microinstability who were initially recommended for treatment with physical therapy were enrolled in this study. Formal physical therapy sessions focused on strengthening the hip and core muscles. These sessions took place twice a week for a minimum of 6 weeks in conjunction with a home exercise program. The number of patients who eventually underwent surgical treatment and the clinical scores for the cohort (modified Harris Hip Score [mHHS] and 33-item International Hip Outcome Tool) were recorded. Results: A total of 64 patients (63 female, 1 male), with a mean ± SD age of 32.2 ± 10.5 years, were identified and studied. Onset of symptoms was insidious (n = 45; 70.3%), acute atraumatic (n = 12; 18.8%), and traumatic (n = 7; 10.9%). A total of 9 (14.1%) patients were high-level athletes. After a follow-up of 45.7 ± 14.6 months, 14 (29.8%) patients eventually underwent hip arthroscopy for persistent hip pain. Capsular plication was performed in all surgical cases. High-level athletes were not more likely to need surgery (50% vs 26.8%; P = .34). The mHHS was available in 24 patients who were treated nonoperatively, and it improved from 67.4 to 85.0 ( P < .01). Conclusion: More than two-thirds of patients treated for hip microinstability were able to avoid surgery; they were successfully treated nonoperatively with physical therapy and a home exercise program and demonstrated improved clinical outcome scores.
Minimally Adequate Treatment for Depression and Anxiety Associated With Mortality in Primary Care Older Adults
Authors: Vasiliadis Helen-Maria , Lamoureux-Lamarche Catherine , Grenier Sébastien , Roberge Pasquale 
Published: March 2022

Objective To assess the association between receipt of minimally adequate treatment (MAT) and mortality in a sample of community primary care older adults with depression and anxiety. Method The present study was conducted among a sample of 358 older adults ( ≥ 65 years old) with depression or an anxiety disorder recruited in primary care practices between 2011 and 2013. Participants agreed to link their health survey and administrative data for the 3 years preceding and following the baseline interview. Depression and anxiety disorders were based on self-reported symptoms aligned with DSM-5 criteria and physician diagnoses (International Classification of Diseases [ICD], 9th and 10th revisions). MAT was defined according to Canadian guidelines and include receipt of pharmacotherapy and ≥ 4 medical visits within 3 months or a number of psychotherapy sessions (individual, group, or family) over 12 months (depression: ≥8; anxiety disorders: ≥5 to 7). All-cause 3-year mortality was ascertained from the vital statistics death registry in Québec. Propensity score weighted regression analysis was conducted to assess the association between receipt of MAT and mortality adjusting for individual, clinical, and health system study factors. Results Receipt of MAT was associated with a reduced risk of mortality (hazard ratio [HR]: 0.27; 95% confidence interval [95% CI], 0.12 to 0.62). Individual and clinical factors associated with increased mortality included older age, male sex, being single, low functional status, and increased physical disorders and cognitive functioning. Lifestyle factors associated with reduced and increased mortality included alcohol consumption and smoking, respectively. Health system factors such as perceived adequate number of visits to speak to the doctor about emotional problems and continuity of care were associated with reduced mortality. Conclusion The current study highlights the important role of primary care physicians in detecting and providing MAT for older adults with depression and anxiety, as this may have an effect on longevity.
Assessment of Workload of ASHAs: A Multi-stakeholder Perspective Study for Task-sharing and Task-shifting
Authors: Manjunath Usha , Sarala R. , Rajendra D. , Deepashree M. R. , Chokshi Maulik , Mokashi Tushar , N. Mythri Shree 
Published: March 2022

The Accredited Social Health Activist (ASHA) programme has proven to be cost-effective and successful in addressing the growing shortage of health workers and reaching the vulnerable. ASHA’s contribution towards the improvement in maternal and child health and other health programmes at the community level is reported and acknowledged widely in literature. However, nearly 16 years into the introduction of ASHA, challenges in terms of workload, fatigue, poor work–life balance and low levels of compensation have emerged. Aim: To assess the workload on ASHAs, impact of their responsibilities on their quality of life and the potential for structured task sharing/shifting among other healthcare workers. Methodology: The study used a mixed-method approach with data and source triangulation. A multi-stage random sampling method was used to collect the data. Qualitative research was carried out to explore ASHAs’ and stakeholders’ perspectives, and a thematic analysis was undertaken using NVivo-12. ASHAs’ quality of life was also measured using the World Health Organization Quality of Life (WHO QOL)-BREF. The study was carried out in three districts of Karnataka: Mysuru, Raichur and Koppala. Results: The majority of ASHAs reported that they experience work burden in terms of population coverage, extended hours of work and additional tasks. Lack of access to transportation, inadequate support from other healthcare personnel and delayed payment of incentives add to them often feeling overworked and underpaid. The research also elicited perspectives on ASHAs’ work from different stakeholders. Findings from the study emphasise the necessity for sharing/shifting of selected tasks among other frontline health workers based on complexity and capabilities.
Open Versus Minimally Invasive Approach for Craniosynostosis: Analysis of the National Surgical Quality Improvement Program-Pediatric
Authors: Rizvi Imran , Harrison Lucas M. , Parsa Shyon , Hallac Rami R. , Seaward James R. , Kane Alex A. 
Published: March 2022

Objective This multicenter study aimed to compare demographic, operative, and short-term outcomes data between open and minimally invasive surgical approaches for craniosynostosis repair utilizing the American College of Surgeon’s National Surgical Quality Improvement Program Pediatric (NSQIP-P) database and highlight surgical disparities among races and ethnicities. Design Retrospective review of large multicenter database. Setting Freestanding general acute care children's hospitals, children's hospitals within a larger hospital, specialty children's hospitals, or general acute care hospitals with a pediatric wing. Patients and Participants A total of 4931 pediatric patients underwent craniosynostosis correction within the NSQIP-P database from 2013 to 2019. Interventions None. Main Outcome Measure(s) Demographic information included age at surgery, sex, race, and ethnicity. Operative and outcomes measures included operative time, anesthesia time, days until discharge, postoperative complications, blood transfusions, 30-day readmission, and 30-day unplanned return to operating room. Results Patients who underwent minimally invasive surgery had significantly shorter operative and anesthesia times ( p < .001; p < .001), fewer days until discharge ( p < .001), fewer postoperative complications ( p < .05), and less blood transfusions ( p < .001). The proportion of White patients was significantly higher in the minimally invasive surgery group ( p < .01), whereas Black and Hispanic patients had a significantly higher proportion in the open surgery group ( p < .001; p < .001). Additionally, the percentage of patients undergoing minimally invasive surgery increased from 3.8% in 2014 to over 13% in 2019. Conclusions This study adds to a growing consensus that minimally invasive surgery has significantly decreased operative time, anesthesia time, transfusion rates, length of hospital stay, and postoperative complications compared to open surgery. Racial and ethnic surgical disparities showed larger proportions of Black and Hispanic populations undergoing open procedures.
A Retrospective Analysis of Hematologic Parameters in Patients with Early Diabetic Kidney Disease
Authors: Chen Xu , Wang Qinghua , Li Chengbin 
Published: March 2022

Objective To retrospectively analyze the hematologic parameters in patients with early Diabetic Kidney Disease (DKD) to define potential biomarkers that can be used to predict early DKD. Methods 134 diabetic patients without nephropathy and 49 patients with early DKD were enrolled for this study and the hematologic parameters were retrospectively analyzed. Paired comparison was conducted by T-test and the predicting value of any statistically different parameter was tested using the Receiver Operating Characteristic curve (ROC) analysis model. Results The number of Neutrophil (N) was higher ( P <0.001) while monocyte (M) was lower ( P <0.01) in the early DKD group than that of DM group without nephropathy. In addition, neutrophil to lymphocyte ratio (NLR) was higher while platelet to lymphocyte ratio (PLR) was significantly lower in the early DKD group( P <0.001). Results from ROC curve analysis showed the sensitivity and specificity of PLR to predict early DKD were 83.7% and 82.6%, respectively. Conclusions PLR may be a potential hematologic parameter that can be used to predict early DKD.