bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of hs-CRP is Associated with lower 2-year MACCEs Following Percutaneous Coronary Intervention in Non-diabetic Patients with Acute Coronary Syndrome
Authors: Zhang Lisha , Zhang Yan , Deng Fuxue , Chu Chao , Yuan Zuyi , Zhang Mingjuan 
Published: September 2022

Abstract
Background: C-reactive protein (CRP) plays a pivotal role in acute coronary syndrome(ACS) and diabetes mellitus (DM). Few data from non-diabetic ACS populations on the association of high-sensitivity CRP (hs-CRP) and long-term prognosis are available. This study aimed to investigate the relationship between baseline hs-CRP and the 2-year major cardiovascular and cerebrovascular adverse events (MACCEs) following percutaneous coronary intervention (PCI) of non-diabetic patients with ACS.
Methods: We divided participants (n=419)into two groups according to baseline hs-CRP level to compare baseline characteristics and clinical outcomes. Cox regression and survival analysis of MACCE was performed at a median follow-up of 32.43 months. We also plot the receiver operating characteristics (ROC) curves of hs-CRP in predicting 2-year MACCEs.
Results: The incidence of MACCEsin the lower-hs-CRP (L-CRP) (12.4%) group was higher than that in the higher-hs-CRP (H-CRP) (5.6%) group (P = 0.020). In COX regression analysis, the H-CRP (HR 0.975, 95% CI 0.637-0.992, P= 0.043) group was associated with lower MACCEs compared with the L-CRP group after adjusting for confounders.
Conclusion: Elevated baseline hs-CRP levels may be a protector maker in predicting a lower incidence of MACCEs following PCI in ACS patients without glucose metabolism disorder.
Seroprevalence and associated risk factors for brucellosis and leptospirosis in swine raised in small-scale farms from rural communities of Tandil county (Buenos Aires province, Argentina)
Authors: Silva Julia A. , Scialfa Exequiel A. , Gutiérrez Silvina E. , Tisnés Adela , Rodríguez Marcelo G. , Estein Silvia M. , Rivero Mariana A. 
Published: September 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
Factors Associated with Peritoneal Recurrence in Patients with Colorectal Cancer having Minimal Serosal Involvement: A Pooled Analysis of Randomized Comparative Study
Authors: Ahmed Ihab S. , Soliman Hany , Maamoun Sherif Ismail , Abdelkader Khadiga Amr , Khaled Islam 
Published: September 2022

Abstract
Background: Peritoneal carcinomatosis (PC) is an uncommon recurrence pattern, which accounts for 3%–6% of local colon cancer and 25% of colorectal cancer recurrences. This study aimed to determine the incidence of PC and investigate its related risk factors after a colectomy.
Methods: This prospective, interventional, randomized, comparative, single-center study recruited adult patients who are scheduled to undergo colectomy. Here, we pooled the data of all patients to assess the risk factors for PC recurrence for 18 months of follow-up.
Results: The median peritoneal recurrence-free survival (PRFS) was 16 months, and the cumulative 1-year and 18-month PRFS was 52.4% and 30.6%, respectively. No statistically significant associations were found between the PRFS and any of the preoperative characteristics of patients. The nodal stage had a statistically significant effect on developing peritoneal recurrence. The higher the tumor nodal burden, the higher the risk for developing future PC compared to lower nodal stages (p = 0.039). Additionally, elevated tumor markers during the follow-up period were highly predictive of peritoneal recurrence (p = 0.002). The cumulative 18-month PRFS was 50% for patients who underwent hyperthermic intraperitoneal chemotherapy compared to 12.1% in the standard treatment arm group (p= 0.250).
Conclusions: This study revealed a high incidence of recurrent PC in high-risk patients after colectomy and the association of lymph node involvement with a higher risk of recurrent PC. However, further studies are required to investigate the prognostic risk factors in a larger sample and different patient groups.
Recurrence intervals for M &gt; 7 Miyagi-ken-Oki earthquakes during an M ~ 9 earthquake cycle
Authors: Nakata Ryoko , Uchida Naoki , Hori Takane , Hino Ryota 
Published: September 2022

Abstract
The 2011 Tohoku-Oki earthquake made it difficult to evaluate the long-term probability of seismic activity along the Japan Trench because the impact of the unprecedentedly large slip is unknown. This study aims to evaluate the long-term probability of an M > 7 earthquake off the Miyagi Prefecture, in the middle segment of the Japan Trench. We conducted numerical simulations of earthquake generation cycles based on the rate- and state-dependent friction law that represents the process of stress accumulation and release on the plate interface. To validate the simulation results, we examined observation data, including time intervals and afterslip distributions, for previous Miyagi-ken-Oki earthquakes. We then compared the simulation results with repeating-earthquake-derived interplate slip observations before and after the 2011 Tohoku-Oki earthquake. Subsequently, we demonstrated that the spatial and temporal characteristics of aseismic slips on the plate interface near the M > 7 Miyagi-ken-Oki source were qualitatively reproduced. These simulation results revealed that the recurrence interval of M > 7 Miyagi-ken-Oki earthquakes varied throughout an M ~ 9 earthquake cycle along the Japan Trench. The time interval between the first M > 7 earthquake following the M ~ 9 earthquake was shorter than the average recurrence interval of M > 7 earthquakes during the latter stage in the cycle. Following years- to decades-long quiescent period after an M ~ 9 earthquake, an M > 7 earthquake occurred at the downdip edge of the coseismic slip area of the M ~ 9 earthquake. The longest period of quiescence occurred prior to the subsequent M > 7 earthquake. Recurrence intervals of M > 7 earthquakes were typically inconsistent in the early stage than in the latter stage of the M ~ 9 earthquake cycle. These characteristics were caused by the extent of the locked and afterslip areas in and around the source. Hence, for long-term evaluation, it is necessary to observe aseismic slips in and around the source area during the preparation process for earthquakes occurring in the downdip area off the Miyagi Prefecture. Furthermore, earthquake cycle simulation combined with earthquake and slow slip monitoring can provide meaningful insights regarding the evolution of earthquake cycles for great interplate earthquakes.
Protracted Course of SARS-CoV-2 Pneumonia in Severely Immunocompromised Patients
Authors: Lee Jeongjae , Kim A Reum , Kang Sung Woon , Chang Euijin , Bae Seongman , Jung Jiwon , Kim Min Jae , Chong Yong Pil , Lee Sang-Oh , Choi Sang-Ho , Kim Yang Soo , Kim Sung-Han 
Published: September 2022

Abstract
Purpose: There have been few studies comparing the clinical manifestations of SARS-CoV-2 pneumonia in individuals with and without severely immunocompromised conditions.
Methods: We reviewed adult patients with SARS-CoV-2 infection who had radiologic evidence of pneumonia at a tertiary hospital in Seoul, South Korea from February 2020 to April 2022. Severely immunocompromised status was defined as solid organ transplantation (SOT) or hematologic malignancy. The time to pneumonia development was defined as the time from symptom onset to the time when radiologic evidence of pneumonia was obtained. Viral clearance was defined as a Ct value >30. COVID-19-related death was defined as 90-day death following imaging-confirmed pneumonia without any other plausible cause of death.
Results: A total of 467 patients with SARS-CoV-2 pneumonia were analyzed. Of these, 86 (25%) were severely immunocompromised, with 29 (34%) SOT and 57 (66%) hematologic malignancy, and 381 (75%) were not severely immunocompromised. The median (interquartile range [IQR]) time to pneumonia development was significantly longer in the severely immunocompromised patients (10 [7-15] days) than the comparator (6 [3-8] days), p < 0.001), as was the median (IQR) time to viral clearance (19 [13-25] days versus 11 [9-15] days, p < 0.001). Severely immunocompromised status (adjusted odds ratio, 5.70; 95% confidence interval, 2.09-15.56; p < 0.001) was independently associated with COVID-19-related death.
Conclusion: Patients who receive SOT or have hematologic malignancies are likely to experience a more protracted course of SARS-CoV-2 pneumonia and a worse outcome than those without these conditions.
Extra-virgin Avocado (Persea americana Mill.,Laucaceae) Oil Improves Cognitive Impairment in D-galactose-induced Alzheimer’s Disease Model on Ovariectomized Wistar Rat
Authors: Ndé Christelle Massop Wamba , Djiogue Sefirin , Awounfack Charline Florence , Gamo Franklin Zemo , Tedjo Florette Motoum , Tadah Rudig Nikanor Djikem , Njamen Dieudonné 
Published: September 2022

Abstract
Background: Avocado is a tree’s fruit (Persea AmericanaMill.) of the Laucaceae family. It was reported that consumption of avocado improved cognitive performance. No study has yet been carried out regarding the properties of avocado oil supplementation on the occurrence of Alzheimer's disease. The objective of the present study was to evaluate the effects of extra-virgin avocado oil on a model of D-galactose-induced Alzheimer's disease in ovariectomized Wistar rats.
Methods: To accomplish this, 54 female rats were used, of which 42 were ovariectomized (OVX) and 12 underwent white surgery (SHAM). Fourteen days after surgery, the animals were divided into 9 groups of 6 animals each: SHAM+Veh and OVX+Veh groups receiving the vehicle; SHAM + D-gal and OVX+D-gal groups receiving D-galactose and vehicle; OVX+D-gal+E2V and OVX+D-gal+DNPZ groups receiving D-galactose and reference drugs (estradiol valerate and donepezil respectively) and 3 test groups (OVX+D-gal+AO1; OVX+D-gal+AO2 and OVX+D-gal+AO3) receiving D-galactose each and extra-virgin avocado oil at the doses of 0.25, 0.5 and 1 mL/kg respectively. The treatment was carried out during 70 days during which memory disorders were evaluated using the Object Recognition, Y-Maze and MWM tests. Some biochemical parameters regarding memory function were evaluated on hippocampus homogenate 10%. Isolated brain was fixed in 10% formalin for histological analysis.
Results: As results, compared to SHAM+Veh group, deterioration of both non-spatial and spatial memory (short- and long-term) was observed in OVX animals threated with D-galactose. In addition, a significant decrease in relative hippocampal weight (p < 0.001), Ach (p < 0.001), Glu (p < 0.001), GSH (p < 0.001), CAT (p < 0.05), and SOD (p < 0.001) activities, and a significant (p < 0.001) increase in Methylglyoxal, MDA, and NO2-. was noted in OVX+D-gal group. Compared to OVX+D-gal group, the treatment with extra-virgin avocado oil at all tested doses reversed or prevented the negative effects induced by ovariectomy and/or by D-galactose on biochemical and oxidative stress biomarkers. The analysis of hippocampus microarchitecture shows that the extra-virgin avocado oil induced a significant decrease (p < 0.05; p < 0.01; p < 0.001) of neuronal loss in CA1 and CA3 hippocampal region.
Conclusions: Taken together, these results suggest that avocado oil possesses neuroprotective properties and can be consumed or supplemented to prevent the onset of Alzheimer's disease.
Improvement of RNA in situ hybridisation for grapevine fruits and ovules
Authors: Yao Jin , Li Xingmei , Wu Na , Zhang Songlin , Gao Min , Wang Xiping 
Published: September 2022

Abstract
Background: The European grapevine (Vitis vinifera L.) is one of the world’s most widely cultivated and economically important fruit crops. Seedless fruits are particularly desired for table grapes, with seedlessness resulting from stenospermocarpy being an important goal for cultivar improvement. The establishment of an RNA in situ hybridisation (ISH) system for grape berries and ovules is therefore important for understanding the molecular mechanisms of ovule abortion in stenospermocarpic seedless cultivars.
Results: We improved RNA in situ hybridisation procedures for developing berries and ovules targeting two transcription factor genes, VvHB63 and VvTAU, using two seeded varieties, 'Red Globe' and 'Pinot Noir', and two seedless cultivars, 'Flame Seedless' and 'Thompson Seedless'. Optimisation focused on the time of proteinase K treatment, probe length, probe concentration, hybridisation temperature and post-hybridisation washing conditions. The objectives were to maximise hybridisation signal and minimise background interference, while still preserving tissue integrity.
Conclusion: For the target genes and samples tested, the best results were obtained with a pre-hybridisation proteinase K treatment of 30 min, probe length of 150 bp and concentration of 100 ng/mL, hybridisation temperature of 50°C, three washes with 0.2× saline sodium citrate (SSC) solution and blocking with 1% blocking reagent for 45 min during the subsequent hybridisation. The improved ISH system was used to study the spatiotemporal expression patterns of genes related to ovule development at microscopic level.
Adults with Autistic Traits have Delayed Motion Perception of Approaching Life-size Characters: An Event-Related Potentials Study
Authors: Inokuchi Ryo , Ichikawa Hiroko , Yamamoto Masataka , Takemura Hiroshi 
Published: September 2022

Abstract
We investigated the association between gait perception and autistic traits in a real-life setting. Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in visual motion perception. To clarify the difficulty in daily situations caused by ASD motion perception problems, we recorded event related potentials (ERPs) in university students and investigated whether the perception of walking motion displayed by a virtual avatar differs depending on participants’ scores of autistic traits. ERPs were measured in 30 young adults in response to walking motion while passing someone. Videos of a life-sized virtual character approaching and retreating while walking were presented as visual stimuli. ERP components (N170 and P200) were identified in the occipito-temporal region of most participants. Adults with higher autistic traits had longer latencies and smaller P200 amplitudes for the approaching virtual character in the occipito-temporal region. These findings indicate that adults with autistic traits have delayed and less sensitive motion perception of an approaching person; suggesting that adults with autistic traits have atypical motion perception in daily life. This study may contribute to elucidating autistic traits, such as atypical gait and movement disorders, from the perspective of motion perception in an environment close to daily life.
The experience of being a caregiver of patients with digestive cancer, from patients and caregivers perception: a mixed study.
Authors: GRIVEL Charlotte , NIZET Pierre , MARTIN Manon , EVIN Adrien , PECOUT Solange , LEPEINTRE Aurélie , TOUCHEFEU Yann , PROT-LABARTHE Sonia , HUON Jean François 
Published: September 2022

Abstract
Purpose

This study aims to explore the experience of caregivers of patients with digestive cancer and to compare the perspectives of patients and caregivers.

Methods

This was a mixed-methods study on caregiver-patient dyads. Semi-structured interviews with caregivers and their patients were conducted to explore each perspective. Two questionnaires were distributed to caregivers, the Caregiver Reaction Assessment (CRA) and the Supportive Care Needs Survey for Partners and Caregivers (SCNS-PC).

Results

Thirty-two caregivers completed the questionnaires. The CRA showed great self-esteem (3.8 +/- 0.7) and the burden on schedule (3.3 +/- 1). The SCNS-PC showed a need for healthcare service and information (2.0 +/- 0.8). Ten dyads participated in semi-structured interviews. Three themes emerged from caregiver’s interviews: the illness is an upheaval; the feeling of loneliness and helplessness and its consequences; a natural role with positive outcomes. Four themes emerged from the patient's side: the caregiver naturally takes on this role and gets closer; the caregiver is the patient's anchor; the disruption of the caregiver's life; anxiety, guilt, and the desire to protect the caregiver. Comparison of the data identifies many similarities between patients and caregivers, as well as discrepancies with the main theme being their relationship.

Conclusion

This demonstrates the importance of caring for caregivers and considering them in the context of their relationship with the patient to better understand their experience.
RNA-par: An RNA Exterior Loop Predicting Model for RNA Secondary Structure Prediction
Authors: Zhao Qi , Mao Qian , Yuan Wenxuan , He Qiang , Yao Yudong , Sun Qixuan , Zhao Zheng , Fan Xiaoya 
Published: September 2022

Abstract
The non-coding RNA secondary structure largely determines its function. Hence, accuracy in structure acquisition is of great importance. Currently, this acquisition primarily relies on various computational methods. The prediction of the structures of long RNA sequences with high precision and reasonable computational cost remains challenging. Here, we propose a deep learning model, RNA-par, which could partition an RNA sequence into several independent fragments (i-fragments) based on its exterior loops. Each i-fragment secondary structure predicted individually could be further assembled to acquire the complete RNA secondary structure. In the examination of our independent test set, the average length of the predicted i-fragments was 453 nt, which was considerably shorter than that of complete RNA sequences (848 nt). The accuracy of the assembled structures was higher than that of the structures predicted directly using the state-of-the-art RNA secondary structure prediction methods. This proposed model could serve as a preprocessing step for RNA secondary structure prediction for enhancing the predictive performance (especially for long RNA sequences) and reducing the computational cost. In the future, predicting the secondary structure of long-sequence RNA with high accuracy can be enabled by developing a framework combining RNA-par with various existing RNA secondary structure prediction algorithms. Our models, test codes and test data are provided at https://github.com/mianfei71/RNAPar.
Oxidative-stress related lncRNA as a prognostic signature for Clear cell renal carcinoma: a gene dataset analysis
Authors: Zhang Yu , Zhou Guozhong , Shi Wei , Shi Weili , Hu Meijun , Kong Defu , Long Rong , Chen Nan 
Published: September 2022

Abstract
Clear cell renal carcinoma (ccRCC) is a primary malignant tumor of tubular epithelial origin that is most common in the urinary tract. Growing evidence suggests that oxidative stress (OS), which generates high levels of reactive oxygen species (ROS) and free radicals, plays a critical role in human cancer. However, the predictive value of OS-related lncRNAs in ccRCC remains unclear. We constructed a new survival signature from OS-related and diffeomorphic lncRNAs obtained from the Cancer Genome Atlas (TCGA-KIRC). The signature comprised seven lncRNAs: SPART-AS1, AL162586.1, LINC00944, LINC01550, HOXB-AS4, LINC02027, and DOCK9-DT. OS-related lncRNA signatures had higher diagnostic efficiency than clinicopathological variables, with an area of 0.794 under the receiver operating characteristic curve. Additionally, nomograms based on risk scores and clinicopathological variables (age, gender, grade and stage) showed strong predictive performance. High-risk patients are more sensitive to the therapeutic drugs bicalutamide, epothilone, and lapatinib. Our signatures can independently predict the prognosis of patients with ccRCC; however, the mechanism there of needs further investigation.
University literacy in Francophone minority settings: The challenges of teaching effectiveness
Authors: Alhamid Sofyan , St-Amand Jérôme , Courdi Clémentine 
Published: September 2022

Abstract

At the University of Alberta's Campus Saint-Jean, the only French-speaking campus in the province of Alberta in Canada, students are confronted with a variety of French spoken by professors, causing many challenges for learners who, for the most part, have French as their second language. This linguistic plurality among the faculty prompted us to explore the linguistic and pedagogical challenges that this diversity can create in the classroom. We used a qualitative method of inquiry to collect the corpus of this research. Specifically, we chose a written questionnaire with open-ended questions. The participants comprised 71 students (26 native French speakers and 45 non-native French speakers) enrolled in a bachelor program at the Campus Saint-Jean. Results indicated that this linguistic plurality posed many emotional, cognitive, and learning challenges for the participants of this study. These results are discussed in the perspective of teacher effectiveness.
Effect of changes in METs and incident cardiovascular disease in type 2 diabetes : A nationally representative cohort study
Authors: Lim Yohwan , Kim Hye Jun , Yoon Sung Soo , Lee Sang Jun , Lee Myeong Hoon , Park Hyewon , Park Sun Jae , Jeong Seogsong , Han Hyun Wook 
Published: September 2022

Abstract
Background: Physical activity is known to have strong benefits on prevention and management of cardiovascular disease (CVD). Also, diabetes is known to increase the risk of cardiovascular disease-related morbidity and mortality. However, the evidence of association between changes in physical activity and risk of cardiovascular disease is limited, especially among patients with type 2 diabetes (T2DM).
Methods: A total of 20,598 patients with newly diagnosed diabetes were extracted from the Korean National Health Insurance Service-Health Screening Cohort. Self-reported questionnaires using a 7-day recall method were used to assess physical activity and calculated in metabolic equivalent task (MET) score. Physical activity level was measured in the screening period Ⅰ (2009-10) and period Ⅱ (2011-12) and assessed the change in physical activity level with CVD risks. Hazard ratio (HR) and 95% confidence interval (CI) were calculated using multivariable-adjusted Cox proportional hazards regression.
Results: Compared with the patients from the screening period Ⅰ(2009-10) to period Ⅱ (2011-12), those who increased their physical activity level from sedentary to active showed a 35% lower risk of overall CVD risk (aHR 0.65, 95% CI 0.44-0.96). Inversely, those who decreased their physical activity level from active to sedentary showed a 79% higher risk of overall CVD risk (aHR 1.79, 95% CI 1.17-2.72).
Conclusions: Among patients with newly diagnosed T2DM, change in physical activity showed an inverse relationship with CVD risk. Maintaining a modest level of physical activity is important in reducing CVD risk.
GPU Performance analysis for viscoacoustic wave equations using fast stencil computation from the symbolic specification
Authors: Jesus Lauê , Nogueira Peterson , Speglich João , Boratto Murilo 
Published: September 2022

Abstract
Seismic forward modeling is a computationally and data-intensive stage in the seismic processing workflow. By profiling the kernels of seismic forward modeling algorithms, was observed that they need to access a wide variety of memory locations, in addition to the computational cost of performing floating-point operations for the numerical solution of wave equations. In this context, was used the Roofline model to analyze six representative computing kernels in seismic modeling on GPU environment to indicate bottlenecks in the performance and suggest improvements of these wave equation propagators. Based on this, was implemented six viscoacoustic equations using the Devito tool. Experimental data have shown that optimizations in increasing data reuse and decreasing off-chip memory traffic can significantly improve performance.