bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graves’ disease and the risk of Parkinson’s disease: a Korean population-based study
Authors: Cho Yoon Young , Kim Bongseong , Shin Dong Wook , Youn Jinyoung , Mok Ji Oh , Kim Chul-Hee , Kim Sun Wook , Chung Jae Hoon , Han Kyungdo , Kim Tae Hyuk 
Published: February 2022

Abstract
Two European cohort studies have suggested that Graves’ disease is associated with the development of Parkinson’s disease, although the results were limited and controversial. We evaluated whether patients with Graves’ disease had an increased risk of developing Parkinson’s disease according to treatment modality. We included 65 380 Graves’ disease patients and 326 900 healthy controls matched according to age and sex, using the Korean National Health Insurance database. The primary outcome was the incidences of Parkinson’s disease amongst Graves’ disease patients and controls. Subgroup analyses of Graves’ disease patients were performed according to anti-thyroid drug treatment, radioactive iodine therapy and surgery. The cumulative dose and duration values of anti-thyroid drug were calculated for each patient and categorized into highest, middle and lowest tertiles. Amongst 65 380 Graves’ disease patients, 301 Parkinson’s disease cases were diagnosed during 453 654 person-years of follow-up. Relative to the controls, and regardless of age, sex or comorbidities, the Graves’ disease patients had a 33% higher risk of developing Parkinson’s disease (hazard ratio: 1.33, 95% confidence interval: 1.17–1.51). Most Graves’ disease patients (96%) had received medical therapy, and increased risks of Parkinson’s disease were observed in the various subgroups for cumulative dose and treatment duration. This study revealed that Graves’ disease was an independent risk factor for developing Parkinson’s disease, and that the risk remained elevated regardless of demographic factors or treatment duration/dosage of the anti-thyroid drug. Clinicians should be aware that Graves’ disease patients have an increased risk of developing Parkinson’s disease, even though Graves’ disease patients are often relatively young.
Aging in the Right Place: A Conceptual Framework of Indicators for Older Persons Experiencing Homelessness
Authors: Canham Sarah L , Weldrick Rachel , Sussman Tamara , Walsh Christine A , Mahmood Atiya 
Published: February 2022

Abstract
Aging in place may not be a universally optimal goal nor accessible to all. Research has highlighted the significance of aging in the right place (AIRP) by recognizing that secure housing for older adults should support one’s unique vulnerabilities and lifestyles. Despite the evolving conceptualization of AIRP for general populations of older adults, considerations of AIRP relevant for older people with previous or current experiences of homelessness are absent from the existing literature. Given this conceptual gap, we developed a framework of indicators relevant for older persons experiencing homelessness. We engaged community partners in the development of our framework and examined what had been described in prior research on aging in place and person–environment fit for older adults. The resulting conceptual framework is comprised of 6 subcategories of indicators: (a) built environment of the housing unit and surrounding neighborhood, (b) offsite and onsite health and social services and resources, (c) social integration, (d) stability and affordability of place, (e) emotional place attachment, and (f) broader political and economic contexts. This framework provides a practical and meaningful contribution to the literature which can be used to promote AIRP for individuals whose experiences are often not reflected in existing models.
Current Topics in Research, Care, and Welfare of Common Marmosets
Authors: Burns Monika , Silva Afonso C 
Published: February 2022

Abstract
Although the common marmoset (Callithrix jacchus) has been maintained in captivity in biomedical research settings for decades, interest and use of the species as an animal model for a diverse array of purposes has increased in the 21st century. Unfortunately, the development of validated animal care standards such as nutrition, husbandry, and clinical care has not expanded with the same rapidity as the use of the species in research. The goal of this themed issue of the ILAR Journal is to review current literature relevant to topics that impact marmoset health, welfare, and use in research. As the population of captive marmosets increases worldwide, the editors urge scientists, veterinary clinicians, and colony managers to continue conducting and publishing robust studies to develop evidence-based standards related to marmoset care and use. The editors also encourage IACUCs and other institutional review bodies to seek training on topics relevant to marmoset welfare and develop related policies prior to acquiring animals as a novel species.
The Ownership of Data
Authors: Dosis Anastasios , Sand-Zantman Wilfried 
Published: February 2022

Abstract
We study the effects of property rights over the use of data on market outcomes. To do so, we consider a model in which a monopolistic firm offers a service to a set of heterogeneous users. The use of the service generates valuable data, but data monetization entails a privacy cost for users. A trade-off emerges between under-processing and over-monetization of data. We show that both the firm and users prefer the users (the firm) to own the rights for low (high) values of data. We further discuss the robustness of our results when allowing more possible contracts for the data owner and show that the main trade-off is robust to these extensions.
Blunt cardiac injury presenting as a left-sided coronary artery dissection
Authors: Park Alex , Principe Daniel R 
Published: February 2022

Abstract
The presentation of blunt cardiac injuries (BCIs) following thoracic trauma is extremely varied, classically affecting the right-sided chambers of the heart. In extremely rare cases, BCIs can affect the coronary arteries. Diagnosing a traumatic coronary dissection can be challenging, as not only is presentation highly variable, but dissections are often masked by concomitant injuries. Here, we present the unusual case of a patient presenting to the emergency department following blunt thoracic trauma from an automobile accident. He demonstrated diffuse S and T wave segment elevations on electrocardiogram, and coronary angiography was significant for occlusion of the apical left anterior descending artery and stenosis of the second obtuse marginal artery. The patient was diagnosed with a BCI causing a left-sided coronary artery dissection. This serves as an important reminder that BCIs can manifest in any part of the cardiac anatomy, and should be considered in any patient with a history of thoracic trauma.
The anchoring of long-term inflation expectations of consumers: insights from a new survey
Authors: Galati Gabriele , Moessner Richhild , van Rooij Maarten 
Published: February 2022

Abstract
We provide new evidence on the level and probability distribution of consumers’ long-term expectations of inflation in the euro area and the Netherlands, using a new monthly representative Dutch survey before and during the COVID-19 pandemic. We find that consumers’ expectations of euro area and Dutch inflation 10 years ahead have not been well anchored at the ECB’s inflation aim of below, but close to 2%. Median expectations have remained elevated above the European Central Bank's (ECB) inflation aim throughout the pandemic. Moreover, individual probability distributions show that expected probabilities of higher inflation (4% or higher) have continuously been larger than those of lower inflation (0% or lower). While policymakers are currently concerned about a possible de-anchoring of inflation expectations on the downside, our results suggest that from a consumer’s point of view de-anchoring of long-term inflation expectations is mainly due to expected high inflation rather than low inflation.
Exploring the basal topology of the heteronemertean tree of life: establishment of a new family, along with turbotaxonomy of Valenciniidae (Nemertea: Pilidiophora: Heteronemertea)
Authors: Kajihara Hiroshi , Abukawa Shushi , Chernyshev Alexei V 
Published: February 2022

Abstract
With about 480 known species, Pilidiophora (phylum Nemertea) has been regarded as consisting of Hubrechtiiformes (~20 spp.) and Heteronemertea (~460 spp.). Most (~87%) of the latter belong to Lineidae (&gt; 400 spp.), while the systematics of non-lineid heteronemerteans remains largely untouched. To explore the phylogeny of non-hubrechtiiformid, non-lineid pilidiophorans, we performed multilocus molecular phylogenetic analyses with five genes (18S, 28S, H3, 16S and COI) from 41 newly sequenced specimens. Pilidiophora comprised Hubrechtellidae, Lineidae, Valenciniidae, the new family Eopilidiidae and a not formally named family-level heteronemertean taxon. Eopilidion misakiense gen. et sp. nov. is described from a specimen from Japan, but whether it belongs to Heteronemertea remains unclear. Apart from this new species, the following 11 new species of valenciniids are established, based on molecular sequences and external morphology (localities in parentheses): Baseodiscus giribeti sp. nov. (Panama), B. kakuii sp. nov. (Japan), B. komatsui sp. nov. (Japan), B. narusei sp. nov. (Japan), B. ohtsukai sp. nov. (Japan), B. paracelensis sp. nov. (Vietnam), B. profundus sp. nov. (Russian Far East), B. urgorrii sp. nov. (Spain), B. zebra sp. nov. (Japan), Oxypolella hiebertae sp. nov. (Vietnam) and Valencinura jambio sp. nov. (Japan).
Differences in Persistence Between Adult Learners Enrolled in Two Online RN-BSN Progression Tracks
Authors: Shroyer Ashley , Benders David , Smith Daniel J. , Hart Carolyn 
Published: February 2022

Abstract
The purpose of this quantitative, causal-comparative study was to examine if and to what extent differences exist for total Persistence Scale for Online Education-Nursing (PSOE-N) scores and mean persistence factor scores for adult learners enrolled in accelerated academic progression tracks (n = 18) compared with adult learners enrolled in traditional academic progression tracks (n = 26) in online RN-BSN completion programs. Total PSOE-N scores, mean perceived stress and support scores, and goal attachment scores were found to be statistically significantly different (p < .05) between participants enrolled in a traditional track compared with those enrolled in an accelerated track.
Atypical Pathogens Presenting With Pulmonary Consolidations Detected by Cell-Free DNA Next-Generation Sequencing in Patients With Hematologic Malignancies
Authors: Caldararo Mario , Algazaq Jumanah , Schmidt Elizabeth , Joanow Alexa , Mariano Amanda , Predmore Jacqueline , Politikos Ioannis , Cho Christina , Stein Eytan M. , Wen Xiaoyun , Travis William D. , Raible Kevin , Cintron Melvili , Babady N. Esther , Papanicolaou Genovefa , Lee Yeon Joo 
Published: February 2022

Abstract
Identification of pathogens with pulmonary presentation in patients with hematologic malignancies may be challenging because of diagnostic difficulty related to the underlying malignancy and limitations of conventional microbiologic methods. Herein, we present a case series of 3 patients with pulmonary consolidations due to Legionella bozemanae necrotizing pneumonia, Pneumocystis jirovecii pneumonia, and disseminated Scedosporium infection, who were diagnosed by microbial cell-free DNA next-generation sequencing. We observed that this new sequencing modality was in agreement with criterion standard diagnostics, posing a potential solution to the problem of limited capability in diagnosing infections in hematological malignancy patients.
Educational Interventions to Improve Graduating Nursing Students' Practice Readiness
Authors: Shatto Bobbi , Meyer Geralyn , Krieger Mary , Kreienkamp Maria Josefa , Kendall Ashley , Breitbach Nicole 
Published: February 2022

Background:
For practice readiness, graduates need minimal competence in many areas. The American Association of Colleges of Nursing (AACN) identified 10 domains of competence.

Purpose:
The aim was to determine whether there is evidence of the objective assessment of learning in the senior year that aligns with the new AACN domains.

Methods:
A systematic literature review included English language, final year, baccalaureate program, and outcomes objectively measured. Master's and midwifery programs were excluded. Database searches by a reference librarian (March 24, 2020) in Scopus, CINAHL, Ovid MEDLINE, ERIC, and Web of Science resulted in 40 peer-reviewed articles. Samples ranged from 9 to 527. Three authors examined results ensuring rigor, decreasing bias, and categorizing articles into the AACN's 10 domains. MERSQI scoring was applied.

Results:
Six of the 10 domains were addressed in the literature. Many studies used investigator-developed tools with no validity or reliability.

Conclusions:
An emphasis on practice readiness means educators must be able to teach and measure critical behaviors.
Men in Nursing Academia
Authors: Hand Mark C. , Reid Ashley 
Published: February 2022

Background:
Currently, there is a shortage of males holding faculty positions in schools of nursing. Minimal research has been conducted to address the shortage of male faculty.

Purpose:
The purpose of this study was to identify factors related to recruitment and retention of men in the faculty role.

Methods:
In this multisite descriptive design, 242 male faculty completed the electronic Nurse Educator Recruitment and Retention Survey.

Results:
Top strategies regarding attraction to the role were opportunity to work with students and to help shape the nursing profession, and nurse faculty role modeling. Top recruitment strategies were increased salaries, employee benefits, having discussions with students, and flexibility in working hours. Retention strategies reported were a positive work environment and support from administration.

Conclusion:
The factors identified from this study are essential for the recruitment and retention of men in faculty roles.
Nursing Students' Self-Efficacy in Immigrant Health
Authors: McDermott-Levy Ruth , Mariani Bette , Lupinacci Paul 
Published: February 2022

Background:
The United States has the largest, most diverse immigrant population. Nurses will care for immigrant clients in all areas of nursing practice.

Purpose:
The purpose of this study was to determine nursing students' self-efficacy in working with immigrant clients following a service-learning experience.

Methods:
A pre-/posttest descriptive study was used to measure students' self-efficacy in cultural aspects of screening, providing health education, and assisting with health care access prior to and after a voluntary service-learning experience at a resettlement agency.

Results:
Statistical significance was found in overall scale score and in all 19 individual items except 2 related to working with (P = .21) and communicating with (P = .49) the health care team. Overall, pretest and posttest results revealed that students' self-efficacy working with immigrant clients was improved.

Conclusion:
Collaborating with an immigrant resettlement program to provide a structured immigrant health learning experience for prelicensure nursing students can improve self-efficacy in working with immigrant clients.
Surgical Complications and Hospital Costs in Robot-Assisted Versus Conventional Laparoscopic Hysterectomy With Concurrent Sacrocolpopexy: Analysis of the Nationwide Readmissions Database
Authors: Andiman Sarah E. , Bui Anthony H. , Ascher-Walsh Charles , Wright Jason D. , Xu Xiao 
Published: February 2022

Objectives
Despite increasing use of robotic technology for minimally invasive hysterectomy with sacrocolpopexy, evidence supporting the benefits of these costly procedures remains inconclusive. This study aimed to compare differences in perioperative complications, 30-day readmissions, and costs between robot-assisted and conventional laparoscopic hysterectomy with concurrent sacrocolpopexy using a large national database.

Methods
Using the 2009–2015 Nationwide Readmissions Database and procedure codes, we identified patients who underwent a robot-assisted or conventional laparoscopic hysterectomy with sacrocolpopexy. We measured in-hospital perioperative complications using diagnosis and procedure codes and measured 30-day readmissions based on patient linkages across hospitalizations. Hospital costs were estimated using charges and cost-to-charge ratios. These outcomes were compared between robot-assisted and conventional laparoscopic procedures using bivariate and multivariable regression analysis.

Results
Our weighted sample included a total of 7,675 patients. Major perioperative complications occurred in 6.7% of robot-assisted and 11.2% of conventional laparoscopic procedures (unadjusted P < 0.001; adjusted odds ratio, 0.69; 95% confidence interval, 0.51–0.93; P = 0.02). Hospital costs were higher in robot-assisted than in conventional laparoscopic procedures (respective median costs, $16,367 vs $13,898; P < 0.001), with an adjusted cost ratio of 1.24 (95% confidence interval, 1.17–1.31; P < 0.001). The risk of 30-day readmission was similar between robot-assisted and conventional laparoscopic procedures.

Conclusions
Nationally representative data suggest that, in laparoscopic hysterectomy with sacrocolpopexy, the robot-assisted approach is associated with a lower risk of perioperative complications, despite higher costs, compared with the conventional one. The risk of 30-day readmission was similar between the robot-assisted and conventional laparoscopic approaches.
Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns
Authors: Sørensen Simon G. , Shrikhande Amruta , Poulsgaard Gustav A. , Christensen Mikkel H. , Bertl Johanna , Hoffmann Eva R. , Pedersen Jakob S. 
Published: February 2022

ABSTRACTDNA repair deficiencies in cancers may result in characteristic mutational patterns, as exemplified by deficiency of BRCA1/2 and efficacy prediction for PARP-inhibitors. We trained and evaluated predictive models for loss-of-function (LOF) of 145 individual DDR genes based on genome-wide mutational patterns, including structural variants, indels, and base-substitution signatures. We identified 24 genes whose deficiency could be predicted with good accuracy, including expected mutational patterns for BRCA1/2, MSH3/6, TP53, and CDK12 LOF variants. CDK12 is associated with tandem-duplications, and we here demonstrate that this association can accurately predict gene deficiency in prostate cancers (area under the ROC curve=0.97). Our novel associations include mono- or biallelic LOF variants of ATRX, IDH1, HERC2, CDKN2A, PTEN, and SMARCA4, and our systematic approach yielded a catalogue of predictive models, which may provide targets for further research and development of treatment, and potentially help guide therapy.
Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine
Authors: Hawman David W. , Meade-White Kimberly , Clancy Chad , Archer Jacob , Hinkley Troy , Leventhal Shanna S. , Rao Deepashri , Stamper Allie , Lewis Matthew , Rosenke Rebecca , Krieger Kyle , Randall Samantha , Khandhar Amit P. , Hao Linhue , Hsiang Tien-Ying , Greninger Alexander L. , Gale Michael , Berglund Peter , Fuller Deborah Heydenburg , Rosenke Kyle , Feldmann Heinz , Erasmus Jesse H. 
Published: February 2022

AbstractIn late 2021, the SARS-CoV-2 Omicron (B.1.1.529) variant of concern (VoC) was reported with many mutations in the viral spike protein that were predicted to enhance transmissibility and allow viral escape of neutralizing antibodies. Within weeks of the first report of B.1.1.529, this VoC has rapidly spread throughout the world, replacing previously circulating strains of SARS-CoV-2 and leading to a resurgence in COVID-19 cases even in populations with high levels of vaccine- and infection-induced immunity. Initial studies have shown that B.1.1.529 is less sensitive to protective antibody conferred by previous infections and vaccines developed against earlier lineages of SARS-CoV-2. The ability of B.1.1.529 to spread even among vaccinated populations has led to a global public health demand for updated vaccines that can confer protection against B.1.1.529. We report here the rapid development of a replicating RNA vaccine expressing the B.1.1.529 spike and show that this B.1.1.529-targeted vaccine is immunogenic in mice and hamsters. Interestingly, we found that mice previously immunized with A.1-specific vaccines failed to elevate neutralizing antibody titers against B.1.1.529 following B.1.1.529-targeted boosting, suggesting pre-existing immunity may impact the efficacy of B.1.1.529-targeted boosters. Furthermore, we found that our B.1.1.529-targeted vaccine provides superior protection compared to the ancestral A.1-targeted vaccine in hamsters challenged with the B.1.1.529 VoC after a single dose of each vaccine.One Sentence SummaryRapidly developed RNA vaccine protects against SARS-CoV-2 Omicron variant
Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes and gene regulation
Authors: Choudhary Mayank NK , Quaid Kara , Xing Xiaoyun , Schmidt Heather , Wang Ting 
Published: February 2022

ABSTRACTTransposable elements (TEs) are major contributors of genetic material in mammalian genomes. These often include binding sites for architectural proteins, including the multifarious master protein, CTCF. These TE-derived architectural protein binding sites shape the 3D genome by creating loops, domains, and compartments borders as well as RNA-DNA chromatin interactions, all of which play a role in the compact packaging of DNA in the nucleus and have the potential to facilitate regulatory function.In this study, we explore the widespread contribution of TEs to mammalian 3D genomes by quantifying the extent to which they give rise to loops and domain border differences across various cell types and species using a variety of 3D genome mapping technologies. We show that specific (sub-)families of TEs have significantly contributed to lineage-specific 3D chromatin structures in specific mammals. In many cases, these loops have the potential to facilitate interaction between distant cis-regulatory elements and target genes, and domains have the potential to segregate chromatin state to impact gene expression in a lineage-specific and cell-type-specific manner. Backing our extensive conformation study cataloguing and computational analyses, we perform experimental validation using CRISPR-Cas9 to delete one such candidate TE and show disruption of species-specific 3D chromatin structure.Taken together, we comprehensively quantify and selectively validate our finding that TEs contribute significantly to 3D genome organization and continuously shape it to affect gene regulation during the course of mammalian evolution over deep time.