bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compatibility between delay functions and highway capacity manual on Iraqi highways
Authors: Mahdi Mohammed Bally , Alrawi Areaj Khairy , Leong Lee Vien 
Published: May 2022

Abstract
Volume delay functions (VDFs) are mathematical relationships used by the traffic allocation step of demand forecasting models to take into account the effect of increased traffic flow on the time spent to travel each possible route between different travel sources and destinations. The VDF is usually applied in static traffic assignment to describe the resultant link travel times, as a function of flow and capacity and free-flow travel time. This study aims to investigate the interface between the delay functions used by demand forecasting models and the highway capacity manual (HCM) model flow-speed relationships. The most commonly used VDFs in transport demand modeling packages in the literature were identified. The Bureau of Public Roads (BPR), conical functions (CF), Akçik and Troutbeck function (ATF), and delay logistics function (LF) were described. The four VDFs and the current HCM models were calibrated for the Iraqi road environment, and their compatibilities were examined. Results show that the best adjustments were obtained using the BPR function (quadratic error 0–0.012) and LF (quadratic error 0–0.002). The roles of CF and ATF were used with care, as both appear to neglect the delay in the condition of small to medium traffic patterns typical to country roads. Particularly, in response to single-lane roads, the LF has proven to be useful due to its potential to represent significant delays for low traffic flows and simultaneously produce more delays in congestion conditions; furthermore, the effect of flow as well as intersection spacing is obviously nonlinear. As flow reaches 600 pcu/h/lane, running time increases quickly. With more intersections per kilometer, the impact is obviously greater.
Molecular docking and molecular dynamics approach to identify potential compounds in Huperzia squarrosa for treating Alzheimer’s disease
Authors: Tung Bui Thanh , Hang Ta Thi Thu , Kim Nguyen Bao , Nhung Nguyen Hong , Linh Vu Khanh , Thu Dang Kim 
Published: May 2022

Abstract

Objectives
Alzheimer’s disease (AD) is a lingering progressive neurodegenerative disorder that causes patients to lose cognitive function. The enzyme Acetylcholinesterase (AChE), Butyrylcholinesterase (BuChE), Monoamine oxidase A (MAO A), Beta-secretase cleavage enzyme (BACE 1) and N-methyl-D-aspartate (NMDA) receptors play an important role in the pathogenesis of Alzheimer’s disease. Therefore, inhibiting enzymes is an effective method to treat Alzheimer disease. In this study, we evaluated in silico inhibitory effects of AChE, BuChE, MAO A, BACE 1 and NMDA enzyme of Huperzia squarrosa’s compounds

Methods
The three-dimensional (3D) of N-methyl-D-aspartate receptor (PDB ID: 1PBQ), enzyme β-secretase 1 (PDB ID: 4X7I), enzyme monoamine oxidase A (PDB ID: 2Z5X), enzyme butyrylcholinesterase (PDB ID: 4BDS) and enzyme acetylcholinesterase (PDB ID: 1EVE) were retrieved from the Protein Data Bank RCSB. Molecular docking was done by Autodock vina software and molecular dynamics (MD) simulation of the ligand-protein complex with the least binding energy pose was perfomed by MOE. Lipinski Rule of Five is used to compare compounds with drug-like and non-drug-like properties. Pharmacokinetic parameters of potential compounds were evaluated using the pkCSM tool.

Results
Based on previous publication of Huperzia squarrosa, we have collected 15 compounds. In these compounds, huperzine B, huperzinine, lycoposerramine U N-oxide, 12-epilycodine N-oxide showed strongly inhibit the five AChE, BuChE, MAO A, BACE 1 and NMDA targets for Alzheimer’s treatment. Lipinski rule of five and ADMET predict have shown that four above compounds have drug-likeness properties, good absorption ability and cross the blood-brain barrier, which have the most potential to become drugs for the treatment of Alzheimer’s in the future. Furthermore, MD study showed that huperzine B and huperzinine have stability of the docking pose with NMDA target.

Conclusions
In this study, we found two natural compounds in Huperzia squarrosa including Huperzine B and Huperzinine have drug-likeness properties, good absorption ability and cross the blood-brain barrier, which have potential to become drugs for the treatment of Alzheimer’s in the future.
Fabrication of self-assembly CNT flexible film and its piezoresistive sensing behaviors
Authors: Zhou Xiaoyang , Luo Jianlin , Zhang Jigang , Wu Xiaoping , Tao Xuejun , Zhu Min 
Published: May 2022

Abstract
Strain sensors are essential for health monitoring of complex-shaped structures. Here, carbon nanotube thin films (CNTFS) with different double-layers were fabricated on a flexible polyethylene terephthalate substrate using layer-by-layer self-assembly technique, and their resistance behaviors and piezoresistive sensing performances were comprehensively conducted. Results show that the assembled layers of CNTFS are evenly and compactly deposited with about 7–15 μm, and the resistance decreases with the increase in the assembly layer number. The piezoresistive sensing behavior increases first and then decreases with the increase in the number of assembly layers along with compression or tension cyclic loading; the nine-double-layer CNTFS shows the best linearity, sensitivity, hysterics, and repeatability of 3.22%, 0.12684/mm, 2.16%, and 3.06%, respectively.
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component
Authors: Leong Jia Xuan , Raffeiner Margot , Spinti Daniela , Langin Gautier , Franz‐Wachtel Mirita , Guzman Andrew R , Kim Jung‐Gun , Pandey Pooja , Minina Alyona E , Macek Boris , Hafrén Anders , Bozkurt Tolga O , Mudgett Mary Beth , Börnke Frederik , Hofius Daniel , Üstün Suayib 
Published: May 2022

AbstractBeyond its role in cellular homeostasis, autophagy plays anti‐ and promicrobial roles in host–microbe interactions, both in animals and plants. One prominent role of antimicrobial autophagy is to degrade intracellular pathogens or microbial molecules, in a process termed xenophagy. Consequently, microbes evolved mechanisms to hijack or modulate autophagy to escape elimination. Although well‐described in animals, the extent to which xenophagy contributes to plant–bacteria interactions remains unknown. Here, we provide evidence that Xanthomonas campestris pv. vesicatoria (Xcv) suppresses host autophagy by utilizing type‐III effector XopL. XopL interacts with and degrades the autophagy component SH3P2 via its E3 ligase activity to promote infection. Intriguingly, XopL is targeted for degradation by defense‐related selective autophagy mediated by NBR1/Joka2, revealing a complex antagonistic interplay between XopL and the host autophagy machinery. Our results implicate plant antimicrobial autophagy in the depletion of a bacterial virulence factor and unravel an unprecedented pathogen strategy to counteract defense‐related autophagy in plant–bacteria interactions.
Glyoxalase 1 knockdown induces age‐related β‐cell dysfunction and glucose intolerance in mice
Authors: Prevenzano Immacolata , Leone Alessia , Longo Michele , Nicolò Antonella , Cabaro Serena , Collina Francesca , Panarese Iacopo , Botti Gerardo , Formisano Pietro , Napoli Raffaele , Beguinot Francesco , Miele Claudia , Nigro Cecilia 
Published: May 2022

AbstractTight control of glycemia is a major treatment goal for type 2 diabetes mellitus (T2DM). Clinical studies indicated that factors other than poor glycemic control may be important in fostering T2DM progression. Increased levels of methylglyoxal (MGO) associate with complications development, but its role in the early steps of T2DM pathogenesis has not been defined. Here, we show that MGO accumulation induces an age‐dependent impairment of glucose tolerance and glucose‐stimulated insulin secretion in mice knockdown for glyoxalase 1 (Glo1KD). This metabolic alteration associates with the presence of insular inflammatory infiltration (F4/80‐positive staining), the islet expression of senescence markers, and higher levels of cytokines (MCP‐1 and TNF‐α), part of the senescence‐activated secretory profile, in the pancreas from 10‐month‐old Glo1KD mice, compared with their WT littermates. In vitro exposure of INS832/13 β‐cells to MGO confirms its casual role on β‐cell dysfunction, which can be reverted by senolytic treatment. These data indicate that MGO is capable to induce early phenotypes typical of T2D progression, paving the way for novel prevention approaches to T2DM.
Fractional Mathematical Model of Covid-19 with Quarantine
Authors: Nisardi Muhammad Rifki , Kasbawati Kasbawati , Khaeruddin Khaeruddin , Robinet Antonin , Chetehouna Khaled 
Published: May 2022

AbstractThis study aims to observe the dynamics of the spread of COVID-19 with the SIR-Model by considering the quarantine (Q) scheme. We also involve a fractional order in the model. Then the basic reproduction numbers were calculated using the generation matrix method, analyzed the local stability of the fractional model for each equilibrium point, and observed its relation to the basic reproduction numbers. We perform the sensitivity analysis to see the effect of parameters on changes in the basic reproduction numbers. We applied the Grunwald-Letnikov method for numerical simulations. Estimation for parameters was also carried out on the existing parameters in the model to obtain parameter values that could represent the actual conditions. Furthermore, with a fractional model, we approximated the model to the data of COVID-19 in West Sulawesi, Indonesia, so that we could obtain a fractional order since it could describe the data more accurately.Keywords: SIR-Q Model; COVID-19; basic reproduction number; Fractional Mathematical Model; Grunwald Letnikov Method. AbstrakPenelitian ini bertujuan untuk mengkaji dinamika penyebaran COVID-19 dengan model matematika orde fraksional penyebaran penyakit SIR-Q dengan mempertimbangkan skema karantina (Q) untuk mengendalikan penyebaran COVID-19. Bilangan reproduksi dasar dihitung menggunakan metode matriks generasi. Kemudian, dianalisa kestabilan lokal model fraksional untuk titik kesetimbangan dan lalu dianalisa kaitannya dengan bilangan reproduksi dasar. Analisis sensitivitas dilakukan untuk mengamati pengaruh parameter terhadap perubahan bilangan reproduksi dasar. Simulasi numerik dilakukan dengan menggunakan metode eksplisit Grunwald-Letnikov. Estimasi juga dilakukan terhadap parameter yang ada pada model untuk memperoleh nilai parameter yang merepresentasikan kondisi aktual penyebaran COVID-19 di Sulawesi Barat. Selanjutnya dengan model fraksional dilakukan pendekatan terhadap data kasus aktif COVID-19 di Sulawesi Barat sehingga diperoleh orde fraksional tertentu yang menghasilkan pendekatan nilai kasus aktif COVID-19 yang lebih akurat terhadap real data.Kata Kunci: Model SIR-Q; COVID-19; bilangan Reproduksi Dasar; Model Matematika Fraksional; Metode Grunwald-Letnikov.
Application of Genetic Algorithm on Inclusive Labeling of a Graph
Authors: Santoso Kiswara Agung , Setiawan Bagus Arief , Kusbudiono Kusbudiono 
Published: May 2022

AbstractAs science developed, heuristic methods began to be used in graph coloring. Heuristic methods that have been used for graph coloring include Genetic Algorithm, Tabu Search, and Ant Colony Algorithm. A Genetic Algorithm is a method for solving optimization problems. In this study, the Genetic Algorithm will be used for the issue of labeling irregular vertices of inclusive distances to label any graph inclusively. We restrict an inclusive 1-distance to a simple graph using one-point crossover and mutation. The steps are a generation of random chromosomes, evaluating chromosome fitness values with tournament selection, conducting an evolutionary process consisting of one-point crossover and mutation, repeating the process until the termination criteria are met. The results of implementing the genetic algorithm on inclusive labeling can be determined by the chromatic number based on the adjacency matrix. The results of this labeling can be used as an alternative solution to the problem of inclusive labeling.Keywords: Genetic Algorithm; graph labeling; inclusive labeling. AbstrakSeiring berkembangnya ilmu pengetahuan metode heuristic mulai digunakan dalam pewarnaan graf. Metode heuristic yang telah digunakan untuk pewarnaan graf antara lain Algoritma Genetika, Tabu Search, dan Algoritma Semut (Ant Colony). Algoritma Genetika merupakan metode untuk menyelesaikan masalah optimasi. Pada penelitian ini, Algoritma Genetika digunakan untuk masalah pelabelan titik tak-teratur jarak inclusive agar dapat melabeli sebarang graf secara inclusive. Kami membatasi lingkup penelitian dengan menerapkan jarak inclusive 1 pada graf sederhana, menggunakan crossover satu titik dan mutasi. Metode yang digunakan dalam penelitian ini adalah studi literatur dengan mengkaji penggunaan Algoritma Genetika pada pelabelan titik tak-teratur jarak inclusive suatu graf. Langkah-langkah yang dilakukan adalah: pembangkitan kromosom secara acak, evaluasi nilai fitness kromosom dengan tournament selection, melakukan proses evolusi yang terdiri dari crossover satu titik dan mutasi, perulangan proses sampai kriteria pemerhentian terpenuhi. Hasil implementasi algoritma genetika pada pelabelan inclusive adalah dapat mengetahui bilangan kromatik berdasarkan matriks adjacency. Hasil pelabelan ini dapat dijadikan sebagai salah satu alternatif penyelesaian masalah pelabelan inklusif. Kata Kunci : Algoritma Genetika; pelabelan graf; pelabelan inklusif.
Adherencia, suspensión y eficacia terapéutica de los anticonceptivos hormonales en universitarios. Estudio transversal
Authors: Niño Avendaño Carlos Alberto , Vargas Rodríguez Ledmar J. , Andrea Saavedra Paula María 
Published: May 2022

Objetivo: El objetivo del estudio fue estimar la prevalencia de adherencia, suspension y eficacia terapéutica, que puedan desencadenar embarazos no deseados en mujeres universitarias entre los 17 y 30 años de edad, que usan o han usado anticonceptivos hormonales como método de planificación familiar. Materiales y métodos: Se llevó a cabo un estudio observacional, de corte transversal, durante el período compren­dido entre el 15 de enero y 15 de marzo del 2020, donde se incluyeron estudiantes de la facultad de ciencias de la salud de la Universidad Pedagógica y Tecnológica de Colombia. Las variables estudiadas correspondían a datos sociodemográficos, causas de adherencia del tratamiento, cambio de método de planificación y fallo terapéutico. Resultados: el promedio de edad poblacional fue de 21.9 años, evidenciando mayor uso de anticonceptivos orales y el 26.15% eran asesoradas por personal distinto de la salud. El alcohol era la principal sustancia consumida de las que interactúan con los anticonceptivos hormonales. Las principales reacciones adversas eran la cefalea, aumento de peso y sangrado acne. Los principales motivos para la no adherencia, están relacionado con la presencia de efectos adversos. La eficacia terapéutica se presentó en el 10.3% de las encuestadas. Conclusiones: Aunque el estudio evidenciaba que la primera causa de la no adherencia fue el cese de la vida sexual, existe un alto porcentaje de usuarias con reacciones adversas leves y, de acuerdo a la persona que les suministra la información, se puede notar que hay dificultad en el apego al uso de este tipo de medicamentos
Loteamento Serrano: Paisagem de um Processo de Ocupação Periférico
Authors: Da Rocha Gabriel , Lacerda de Lima Bruna , Franceschet Goettems Renata 
Published: May 2022

A industrialização foi o motor de crescimento de diversas cidades no Brasil. Por consequência da urbanização acelerada, parcelas de terra foram ocupadas de forma irregular, criando problemas na esfera do planejamento urbano dessas cidades. O presente trabalho objetiva analisar o processo e a paisagem urbana do Bairro Serrano em Caxias do Sul, no nordeste do Rio Grande do Sul e traçar um panorama de ocupação até os dias atuais. O bairro origina-se de um parcelamento de solo irregular sobre uma bacia de captação de águas. Ao longo da história da gleba, as infraestruturas básicas foram conquistadas com muita mobilização popular até que o Serrano fosse legitimado como bairro no planejamento da cidade de Caxias do Sul. A escala do trabalho baseia-se no perímetro urbano da gleba e sua paisagem imediata. Como metodologia para análise, buscou-se suporte em bibliografias de relatos históricos, documentos oficiais, bem como em metodologias de diagnóstico e análise da paisagem urbana. Para desenvolver o estudo, utilizou-se de informações geoespaciais baseadas em SIG (Sistema de Informação Geográfica) e visitas de campo. Como resultados, encontramos uma paisagem diretamente ligada ao seu processo de ocupação e ao acesso às infraestruturas básicas, com limites e costuras marcantes, bem como marcos visuais que criam memória e sentido de pertencimento aos moradores do bairro.

PALAVRAS-CHAVE: Planejamento. Infraestrutura. Ocupação.
Farklı Kanser Türüne Sahip Bireyler ile Bakım Verenlerinde Fiziksel Aktivite, Yorgunluk Düzeyi ve Yaşam Kalitesinin İncelenmesi
Authors: USGU Serkan , ÖZBUDAK Özge 
Published: May 2022

Amaç: Bu çalışma farklı kanser türüne sahip bireyler ile bakım verenlerinde fiziksel aktivite, yorgunluk ve yaşam kalitesinin incelenmesi amacıyla yapıldı.
Gereç ve Yöntemler: Çalışmaya akciğer kanseri (n=60, yaş: 55.77±7.27 yıl, Vücut Kütle İndeksi-VKİ; 20.22±1.12 kg/m2), meme kanseri (n=60, yaş:49.68±9.51 yıl, VKİ: 20.72±1.18 kg/m2) ve kolon kanseri (n=60, yaş: 52.53±7.77 yıl, VKİ: 19.57±0.92 kg/m2) olmak üzere 180 kanser hastası ve 180 bakım vereni dahil edildi. Fiziksel aktivite düzeyi Uluslararası Fiziksel Aktivite Anketi (IPAQ) ile, yorgunluk ise Piper Yorgunluk Ölçeği ile değerlendirildi. Yaşam kalitesi kanser hastalarında EORTC-QLQ-30, bakım verenlerde ise SF-36 yaşam kalitesi ölçeği ile değerlendirildi.
Bulgular: Yorgunluk akciğer kanseri ve bakım verenlerinde yüksek, meme kanseri ve bakım verenlerinde düşüktü (p
Discretion as a Result of the Formation of the Judge’s Moral Certainty
Authors: Kornakova S. V. 
Published: May 2022

The paper is devoted to the possibility of using judicial discretion, criteria and objective limits of its action in the resolution of criminal cases. The ambiguous attitude of the professional community to discretion in the application of law is noted: from the justification of the necessity and inevitability of its existence in court proceedings to its denial as not conforming to the principle of legality. The author shares the position of scholars that the use of judicial discretion is inevitable in criminal proceedings, since it is dictated by the process of applying the rule of law to specific life situations, but its unjustified expansion is unacceptable.It is concluded that the use of judicial discretion is inextricably linked with the formation of internal conviction. At the same time, the misconceptions about this connection found in scientific sources are critically evaluated. Proceeding from the fact that the criminal procedure law prescribes the court to be based on internal conviction when making decisions, and the use of discretion is the choice of a decision from the alternatives provided for by law, it means that the use of judicial discretion is the result of the formation of an internal conviction of the court. Regarding the question of what should limit the freedom of discretion, the author notes that the answer to it follows from the requirements of Part 4 of Article 7 of the Code of Criminal Procedure on the compliance of any decision in criminal proceedings with the requirement of legality, as well as from the content of Article 17 of the Code of Criminal Procedure, prescribing to be guided in their decisions by internal conviction. The legislator names the law and the conscience of the decision-making subject as the criteria of the latter. Each of these categories reflects the sphere of due, therefore, they should also be factors limiting the freedom of discretion. Therefore, the criteria that ensure the fairness of the judge’s decision at discretion, and at the same time the limitations of its application are the law, internal conviction and conscience of the judge.
Pengaruh Iradiasi Gamma dan Penyimpanan Dingin terhadap Kandungan Proksimat, pH, dan ALT Filet Ikan Jenaha
Authors: Widya Pangestika  , Abrian Satriya , Maulid Deden Yusman , Arumsari Kusuma , Putra Sugili , Windiarti Farakh Fadila , Herawati Vipi 
Published: May 2022

Ikan dan produk perikanan merupakan bahan pangan yang mudah rusak. Salah satu teknologi untuk memperlama daya simpan ikan adalah iradiasi gamma. Iradiasi mampu memutus ikatan rantai DNA bakteri, sehingga menghambat pertumbuhan bakteri. Aplikasi teknologi iradiasi tentunya akan jauh lebih efektif apabila dikombinasikan dengan teknologi pengawetan lainnya, seperti penyimpanan pada suhu dingin. Pada penelitian ini, fillet ikan jenaha (Lutjanus sp.) skinless diiradiasi pada dosis 0 kGy, 3 kGy, 5 kGy, dan 8 kGy. Setelah diiradiasi pada dosis tertentu, fillet ikan disimpan selama 6 hari pada suhu dingin 5oC. Berdasarkan hasil analisis proksimat, diketahui bahwa teknologi iradiasi tidak menyebabkan perubahan yang signifikan terhadap kadar air, kadar abu, dan lemak namun sedikit menurunkan kadar protein pada fillet ikan. Selanjutnya diketahui bahwa dari segi pH, fillet ikan yang tidak diiradiasi dan fillet ikan yang diiradiasi masih dikategorikan sebagai fillet yang segar hingga penyimpanan pada hari ke-6. Walaupun jumlah cemaran bakteri pada fillet ikan tidak diiradiasi jauh lebih besar daripada fillet ikan yang diiradiasi, namun jumlah bakteri kontaminan pada semua perlakuan fillet ikan masih berada di bawah ambang batas yang ditetapkan oleh SNI 7388: 2009. Nilai pH dan jumlah cemaran bakteri pada semua perlakuan fillet ikan cenderung meningkat seiring dengan lamanya proses penyimpanan.
Avances en la aplicación de la Producción Más Limpia: Un análisis bibliométrico entre el periodo 2015-2020
Authors: Saldaña Escorcia Rossember 
Published: May 2022

La implementación de estrategias ambientales como la Producción Más Limpia ha permitido prevenir significativamente la contaminación y los impactos ambientales en los diferentes sectores industriales. Este estudio se enfocó en evaluar la literatura científica generada alrededor de la Producción Más Limpia, a partir de un análisis bibliométrico. Corresponde a un estudio descriptivo con enfoque mixto, sustentado en la indagación de las publicaciones científicas indexadas en la base de datos de Scopus® de Elsevier, así como la implementación del software VOSviewer. Los documentos fueron seleccionados mediante algoritmo de búsqueda con criterios de inclusión y exclusión, durante el periodo abarcado entre los años 2015 y 2020. Se identificaron 52 textos, en los cuales se establecieron que los años con mayor número de publicaciones corresponden a 2019 con el 26.92 % y 2020 con el 23.08 % del total de textos analizados. La revista con mayor número de documentos relacionados con la temática es Journal of Cleaner Production al igual que países como China, Reino Unido y Brasil se posicionan en los primeros lugares en publicaciones. La creciente conciencia pública por el ambiente ha impulsado la Producción más Limpia como estrategia ambiental aportando beneficios en los ámbitos sociales, ambientales y económicos.