bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perylene‐Mediated Electron Leakage in Respiratory Chain to Trigger Endogenous ROS Burst for Hypoxic Cancer Chemo‐Immunotherapy
Authors: Zhang Bianbian , Zheng Rijie , Liu Yuting , Lou Xue , Zhang Wei , Cui Zhanjun , Huang Yongwei , Wang Tie 
Published: November 2022

AbstractPerylene derivatives can be stimulated by the hypoxic tumor microenvironment to generate radical anion that is proposed to arouse electron exchange with oxidizing substance, and in turn, realize reactive oxygen species (ROS) burst. Here, three perylene therapeutic agents, PDI‐NI, PDIB‐NI, and PDIC‐NI, are developed and it is found that the minimum lowest unoccupied molecular orbital (LUMO) energy level makes PDIC‐NI most easily accept electrons from the oxidative respiratory chain to form lots of anions, and the resultant maximum ROS generation, establishing an unambiguous mechanism for the formation of perylene radical anions in the cell, presents solid evidence for LUMO energy level determining endogenous ROS burst. Stirringly, PDIC‐NI‐induced ROS generation arouses enhanced mitochondrial oxidative stress and concurrently activates immunogenic cell death (ICD), which not only efficiently kills lung tumor cells but also reprograms immunosuppressive tumor microenvironment, including the cytokine secretion, dendritic cell maturation, as well as cytotoxic T lymphocytes activation, to inhibit the growth of xenografted and metastasis tumor, presenting a proof‐of‐concept demonstration of perylene that acts as an integrated therapeutic agent to well realize hypoxia‐activated chemotherapy with ICD‐induced immunotherapy on lung cancer.
Advances in Extracellular Vesicle Nanotechnology for Precision Theranostics
Authors: Wu Qian , Fu Siyuan , Xiao Hanyang , Du Jiaxin , Cheng Fang , Wan Shuangshuang , Zhu Houjuan , Li Dan , Peng Fei , Ding Xianguang , Wang Lianhui 
Published: November 2022

AbstractExtracellular vesicles (EVs) have increasingly been recognized as important cell surrogates influencing many pathophysiological processes, including cellular homeostasis, cancer progression, neurologic disease, and infectious disease. These behaviors enable EVs broad application prospects for clinical application in disease diagnosis and treatment. Many studies suggest that EVs are superior to conventional synthetic carriers in terms of drug delivery and circulating biomarkers for early disease diagnosis, opening up new frontiers for modern theranostics. Despite these clinical potential, EVs containing diverse cellular components, such as nucleic acids, proteins, and metabolites are highly heterogeneous and small size. The limitation of preparatory, engineering and analytical technologies for EVs poses technical barriers to clinical translation. This article aims at present a critical overview of emerging technologies in EVs field for biomedical applications and challenges involved in their clinic translations. The current methods for isolation and identification of EVs are discussed. Additionally, engineering strategies developed to enhance scalable production and improved cargo loading as well as tumor targeting are presented. The superior clinical potential of EVs, particularly in terms of different cell origins and their application in the next generation of diagnostic and treatment platforms, are clarified.
Responsive Accumulation of Nanohybrids to Boost NIR‐Phototheranostics for Specific Tumor Imaging and Glutathione Depletion‐Enhanced Synergistic Therapy
Authors: He Liangcan , Zheng Nannan , Wang Qinghui , Du Jiarui , Wang Shumin , Cao Zhiyue , Wang Zhantong , Chen Guanying , Mu Jing , Liu Shaoqin , Chen Xiaoyuan 
Published: November 2022

AbstractDynamic regulation of nanoparticles in a controllable manner has great potential in various areas. Compared to the individual nanoparticles, the assembled nanoparticles exhibit superior properties and functions, which can be applied to achieve desirable performances. Here, a pH‐responsive i‐motif DNA‐mediated strategy to tailor the programmable behaviors of erbium‐based rare‐earth nanoparticles (ErNPs) decorated copper doped metal‐organic framework (CPM) nanohybrids (ECPM) under physiological conditions is reported. Within the acidic tumor microenvironment, the i‐motif DNA strands are able to form quadruplex structures, resulting in the assembly of nanohybrids and selective tumor accumulation, which further amplify the ErNPs downconversion emission (1550 nm) signal for imaging. Meanwhile, the ECPM matrix acts as a near‐infrared (NIR) photon‐activated reactive oxygen species (ROS) amplifier through the singlet oxygen generation of the matrix in combination with its ability of intracellular glutathione depletion upon irradiation. In short, this work displays a classical example of engineering of nanoparticles, which will manifest the importance of developing nanohybrids with structural programmability in biomedical applications.
Electron‐Extraction Engineering Induced 1T’’‐1T’ Phase Transition of Re0.75V0.25Se2 for Ultrafast Sodium Ion Storage
Authors: Fang Yuqiang , Lv Ximeng , Lv Zhuoran , Wang Yang , Zheng Gengfeng , Huang Fuqiang 
Published: November 2022

AbstractInducing new phases of transition metal dichalcogenides by controlling the d‐electron‐count has attracted much interest due to their novel structures and physicochemical properties. 1T’’ ReSe2 is a promising candidate for sodium storage, but the low electronic conductivity and limited active sites hinder its electrochemical capacity. Herein, new‐phase 1T’ Re0.75V0.25Se2 crystals (P2/m) with zig‐zag chains are successfully synthesized. The 1T’’‐1T’ phase transition results from the electronic reorganization of 5d orbitals via electron extraction after V‐atom doping. The electrical conductivity of 1T’ Re0.75V0.25Se2 is 2.7 × 105 times higher than that of 1T’’ ReSe2. Moreover, density functional theory (DFT) calculations reveal that 1T’ Re0.75V0.25Se2 has a larger interlayer spacing, lower bonding energy, and migration energy barrier for Na+ ions than 1T’’ ReSe2. As a result, 1T’ Re0.75V0.25Se2 electrode shows an excellent rate capability of 203 mAh g−1 at 50 C with no capacity fading over 5000 cycles for sodium storage, which is superior to most reported sodium‐ion anode materials. This 1T’ Re0.75V0.25Se2 provides a new platform for various applications such as electronics, catalysis, and energy storage.
Yield loss in rice by acute ozone pollution could be recovered
Authors: Zhang Guoyou , Hu Qinan , Cao Rong , Fu Rao , Risalat Hamdulla , Pan Xiaoya , Hu Yaxin , Shang Bo , Wu Rongjun 
Published: November 2022

AbstractRising concentration of surface O3 threatens crop production and food security. To improve the evaluation and develop efficient adaptations, it is essential to study the effects of acute O3 pollution. We adopted this study by open‐top chamber (OTC) method and found that the fumigation of elevated O3 (NF40) for short (tillering and jointing, heading and ripening) and long periods during rice growth reduced the grain yield by 17, 19 and 25%, respectively, showing that both of the acute and chronic O3 pollution reduce rice production. Moreover, in comparison with the plants under chronic O3 pollution, grain yield was increased when O3 was removed at different stages: 32% increment at tillering and jointing and 34% increment at heading and ripening. These results suggest a possibility to recover the yield loss in rice under O3 pollution.
n‐Involved Optimization of Out‐of‐Plane Optoelectronic Performances in Nanoscale Ruddlesden–Popper Perovskite
Authors: Zhang Zhen Yu , Wang Guo Ping 
Published: November 2022

AbstractRuddlesden–Popper (RP) metal‐halide perovskites are attracting increasing attention due to their improved stability. The intercalated hydrophobic organic layer accounts for this improvement, however, it is detrimental to the out‐of‐plane optoelectronics. Here, the n‐involved performance optimization in RP (PEA)2(Cs)n−1PbnI3n+1 nanomaterials is reported. The exciton is confirmed as the majority of photo‐induced species, but it is more free carrier‐like in n‐larger samples due to the weakened quantum confinement effects. After 90‐day treatment in 65% humidity, it is found that only RP nanomaterials originally designed as n = 4 ((PEA)2(Cs)3Pb4I13) possess the best residual optoelectronic performances (photo‐responsivity and specific detectivity) at minimal drop proportions (≈20%). Particularly, the Coulombic screening effect triggers saturated optoelectronic performances at low driving voltage, due to the almost total depletion of responsive photo‐current even under enhanced external excitations. This work balances the optoelectronic performances and moisture resistance of PEA‐based RP nanomaterials, and is mainly aiming to alleviate the deterioration of optoelectronic performance in 90‐day moisture‐treated (65%) conditions.
Li‐Ion‐Based Electrolyte‐Gated Transistors with Short Write‐Read Delay for Neuromorphic Computing
Authors: Xu Han , Fang Renrui , Wu Shuyu , An Junjie , Zhang Woyu , Li Chao , Lu Jikai , Li Yue , Xu Xiaoxin , Wang Yan , Liu Qi , Shang Dashan 
Published: November 2022

AbstractThe hardware implementation of artificial neural networks requires synaptic devices with linear and high‐speed weight modulation. Memristors as a candidate suffer from excessive write variation and asymmetric resistance modulation that inherently rooted in their stochastic mechanisms. Thanks to a controllable ion intercalation/deintercalation mechanism, electrolyte‐gated transistors (EGTs) hold prominent switching linearity and low write variation, and thus have been the promising alternative for synaptic devices. However, the operation frequency of EGTs is seriously limited by the time that is required for the state stabilization, that is, the write‐read delay after each set/reset operation. Here, a Li‐ion‐based EGT (Li‐EGT) with write‐read delay of 3 ms along with multistates, low energy consumption, and quasi‐linear weight update is introduced. The origin of the short write‐read delay of the device is attributed to the permeable interface between electrolyte and gate electrode. Leveraging the Li‐EGT characteristic, near‐ideal accuracy (≈94%) on handwritten digital image data set has been achieved by the corresponding neural network simulation. These results provide an insight into the development of Li‐EGTs for high‐speed neuromorphic computing.
Programmable WSe2/Ge Heterojunction Field‐Effect Transistor with Visible‐Infrared Wavelength‐Distinguishing Detection Capability
Authors: Yang Maolong , Wang Liming , Lu Yao , Wang Bo , Zhang Ningning , Liu Maliang , Guo Hui , Lin Dongdong , Zhang Jincheng , Hu Huiyong 
Published: November 2022

AbstractProgrammable devices can be easily switched between n‐type and p‐type devices by applying an electric field and are promising candidates for simplifying the currently used fabrication process and increasing programmable flexibility. This paper proposes a 2D WSe2/3D Ge heterojunction field‐effect transistor (JFET) with a top metal‐insulator semiconductor gate. The n‐type and p‐type JFETs are realized based on one device structure; furthermore, the n‐type JFET can be converted into p‐type and vice versa under the control of top‐gate voltages of different polarities. The nJFET and pJFET has low subthreshold swings of 102 and 65 mV dec−1 with a high on/off ratio of ≈105, respectively. Moreover, a visible‐infrared wavelength‐distinguishing photodetector is implemented based on this device. It exhibits a bidirectional photoresponse, wherein the photocurrent polarity is reversed depending on the wavelength of light. Under illumination at 532 nm, positive photoresponsivity is realized through the effective charge separation of the heterojunction. In contrast, the JFET has a negative photoresponsivity at an infrared wavelength of 1550 nm, which is related to type‐I band alignment and the photogating effect. These results indicate that the device has promising potential as a multifunctional optoelectronic device.
“How does your residential environment positively or negatively influence your well‐being?”: A multicase photovoice study with public housing tenants
Authors: Radziszewski Stephanie , Houle Janie , Torres Juan , Leloup Xavier , Coulombe Simon 
Published: November 2022

AbstractPublic housing aims to reduce social inequalities by providing affordable dwellings as a social policy. Anchored in an ecological perspective, the paper reports on a multicase photovoice study documenting public housing tenants' perceptions of how their residential environment influences their well‐being. This design can provide a deeper understanding of the public housing environment to inform change at a programmatic level. To this end, 303 captioned photos were collected by 59 tenant‐researchers at six sites in Québec (Canada). An in‐depth cross‐case analysis of the material led to two key themes with five subthemes each. In the Residential environment perceived as mostly positive theme, the subthemes were access to nature, community resources and services, positive relations among tenants, opportunities for participation, and specific aspects of their home. In the Negative aspects focused on life in public housing theme, the subthemes were strict regulations, lack of respect for tenants' needs, lack of intimacy, lack of proper maintenance, and conflicts between tenants. Findings highlight the dynamic interplay between the residential environment and public housing tenants' well‐being. Two recurring programmatic issues are highlighted: problematic maintenance and limited opportunities for tenants' empowerment. Changes to address these concerns at the programmatic level of public housing could potentially increase tenants' well‐being.
A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal‐Dominant Alzheimer's Disease Trial
Authors: Reiman Eric M. , Pruzin Jeremy J. , Rios‐Romenets Silvia , Brown Chris , Giraldo Margarita , Acosta‐Baena Natalia , Tobon Carlos , Hu Nan , Chen Yinghua , Ghisays Valentina , Enos Jessica , Goradia Dhruman D. , Lee Wendy , Luo Ji , Malek‐Ahmadi Michael , Protas Hillary , Thomas Ronald G. , Chen Kewei , Su Yi , Boker Connie , Mastroeni Diego , Alvarez Sergio , Quiroz Yakeel T. , Langbaum Jessica B. , Sink Kaycee M. , Lopera Francisco , Tariot Pierre N. ,   and the API ADAD Colombia Trial Group
Published: November 2022

AbstractIntroductionThe Alzheimer's Prevention Initiative Autosomal‐Dominant Alzheimer's Disease (API ADAD) Trial evaluated the anti‐oligomeric amyloid beta (Aβ) antibody therapy crenezumab in cognitively unimpaired members of the Colombian presenilin 1 (PSEN1) E280A kindred. We report availability, methods employed to protect confidentiality and anonymity of participants, and process for requesting and accessing baseline data.MethodsWe developed mechanisms to share baseline data from the API ADAD Trial in consultation with experts and other groups sharing data from Alzheimer's disease (AD) prevention trials, balancing the need to protect anonymity and trial integrity with making data broadly available to accelerate progress in the field. We pressure‐tested deliberate and inadvertent potential threats under specific assumptions, employed a system to suppress or mask both direct and indirect identifying variables, limited and firewalled data managers, and put forth specific principles requisite to receive data.ResultsBaseline demographic, PSEN1 E280A and apolipoprotein E genotypes, florbetapir and fluorodeoxyglucose positron emission tomography, magnetic resonance imaging, clinical, and cognitive data can now be requested by interested researchers.DiscussionBaseline data are publicly available; treatment data and biological samples, including baseline and treatment‐related blood‐based biomarker data will become available in accordance with our original trial agreement and subsequently developed Collaboration for Alzheimer's Prevention principles. Sharing of these data will allow exploration of important questions including the differential effects of initiating an investigational AD prevention therapy both before as well as after measurable Aβ plaque deposition.
A Subpopulation of Spikes Predicts Successful Epilepsy Surgery Outcome
Authors: Thomas John , Kahane Philippe , Abdallah Chifaou , Avigdor Tamir , Zweiphenning Willemiek J. E. M. , Chabardes Stephan , Jaber Kassem , Latreille Véronique , Minotti Lorella , Hall Jeff , Dubeau François , Gotman Jean , Frauscher Birgit 
Published: November 2022

ObjectiveEpileptic spikes are the traditional interictal electroencephalographic (EEG) biomarker for epilepsy. Given their low specificity for identifying the epileptogenic zone (EZ), they are given only moderate attention in presurgical evaluation. This study aims to demonstrate that it is possible to identify specific spike features in intracranial EEG that optimally define the EZ and predict surgical outcome.MethodsWe analyzed spike features on stereo‐EEG segments from 83 operated patients from 2 epilepsy centers (37 Engel IA) in wakefulness, non‐rapid eye movement sleep, and rapid eye movement sleep. After automated spike detection, we investigated 135 spike features based on rate, morphology, propagation, and energy to determine the best feature or feature combination to discriminate the EZ in seizure‐free and non‐seizure‐free patients by applying 4‐fold cross‐validation.ResultsThe rate of spikes with preceding gamma activity in wakefulness performed better for surgical outcome classification (4‐fold area under receiver operating characteristics curve [AUC] = 0.755 ± 0.07) than the seizure onset zone, the current gold standard (AUC = 0.563 ± 0.05, p = 0.015) and the ripple rate, an emerging seizure‐independent biomarker (AUC = 0.537 ± 0.07, p = 0.006). Channels with a spike‐gamma rate exceeding 1.9/min had an 80% probability of being in the EZ. Combining features did not improve the results.InterpretationResection of brain regions with high spike‐gamma rates in wakefulness is associated with a high probability of achieving seizure freedom. This rate could be applied to determine the minimal number of spiking channels requiring resection. In addition to quantitative analysis, this feature is easily accessible to visual analysis, which could aid clinicians during presurgical evaluation. ANN NEUROL 2023;93:522–535
Cerebral Cortical Encephalitis in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease
Authors: Valencia‐Sanchez Cristina , Guo Yong , Krecke Karl N. , Chen John J. , Redenbaugh Vyanka , Montalvo Mayra , Elsbernd Paul M. , Tillema Jan‐Mendelt , Lopez‐Chiriboga Sebastian , Budhram Adrian , Sechi Elia , Kunchok Amy , Dubey Divyanshu , Pittock Sean J. , Lucchinetti Claudia F. , Flanagan Eoin P. 
Published: November 2022

Cerebral cortical encephalitis (CCE) is a recently described myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) phenotype. In this observational retrospective study, we characterized 19 CCE patients (6.7% of our MOGAD cohort). Headache (n = 15, 79%), seizures (n = 13, 68%), and encephalopathy (n = 12, 63%) were frequent. Magnetic resonance imaging revealed unilateral (n = 12, 63%) or bilateral (n = 7, 37%) cortical T2 hyperintensity and leptomeningeal enhancement (n = 17, 89%). N‐Methyl‐D‐aspartate receptor autoantibodies coexisted in 2 of 15 tested (13%). CCE pathology (n = 2) showed extensive subpial cortical demyelination (n = 2), microglial reactivity (n = 2), and inflammatory infiltrates (perivascular, n = 1; meningeal, n = 1). Most received high‐dose steroids (n = 17, 89%), and all improved, but 3 had CCE relapses. This study highlights the CCE spectrum and provides insight into its pathogenesis. ANN NEUROL 2023;93:297–302
Plasma Metabolites Link Dietary Patterns to Stroke Risk
Authors: Bhave Varun M. , Ament Zsuzsanna , Patki Amit , Gao Yan , Kijpaisalratana Naruchorn , Guo Boyi , Chaudhary Ninad S. , Guarniz Ana‐Lucia Garcia , Gerszten Robert , Correa Adolfo , Cushman Mary , Judd Suzanne , Irvin M. Ryan , Kimberly W. Taylor 
Published: November 2022

ObjectiveWhile dietary intake is linked to stroke risk, surrogate markers that could inform personalized dietary interventions are lacking. We identified metabolites associated with diet patterns and incident stroke in a nested cohort from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.MethodsLevels of 162 metabolites were measured in baseline plasma from stroke cases (n = 1,198) and random controls (n = 904). We examined associations between metabolites and a plant‐based diet pattern previously linked to reduced stroke risk in REGARDS. Secondary analyses included 3 additional stroke‐associated diet patterns: a Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Southern diet. Metabolites were tested using Cox proportional hazards models with incident stroke as the outcome. Replication was performed in the Jackson Heart Study (JHS). Inverse odds ratio‐weighted mediation was used to determine whether metabolites mediated the association between a plant‐based diet and stroke risk.ResultsMetabolites associated with a plant‐based diet included the gut metabolite indole‐3‐propionic acid (β = 0.23, 95% confidence interval [CI] [0.14, 0.33], p = 1.14 × 10−6), guanosine (β = −0.13, 95% CI [−0.19, −0.07], p = 6.48 × 10−5), gluconic acid (β = −0.11, 95% CI [−0.18, −0.04], p = 2.06 × 10−3), and C7 carnitine (β = −0.16, 95% CI [−0.24, −0.09], p = 4.14 × 10−5). All of these metabolites were associated with both additional diet patterns and altered stroke risk. Mediation analyses identified guanosine (32.6% mediation, p = 1.51 × 10−3), gluconic acid (35.7%, p = 2.28 × 10−3), and C7 carnitine (26.2%, p = 1.88 × 10−2) as mediators linking a plant‐based diet to reduced stroke risk.InterpretationA subset of diet‐related metabolites are associated with risk of stroke. These metabolites could serve as surrogate markers that inform dietary interventions. ANN NEUROL 2023;93:500–510
Synthesis and performance evaluation of crosslinker for seawater‐based fracturing fluid
Authors: Miao Guohao , Zhang Hai , Yang Yu , Qu Jin , Ma Xinru , Zheng Junping , Liu Xiaofei 
Published: November 2022

AbstractZirconium is one of the most commonly used crosslinkers for guar gum‐based fracturing fluid. Nevertheless, it is difficult for zirconium crosslinkers applied in fracturing to possess both high temperature resistance and adjustable crosslinking time. Meanwhile, few people did systematical research on the crosslinking process of fracturing fluid. In this study, an organic zirconium crosslinker with high temperature resistance and controllable crosslinking time was synthesized. The seawater‐based fracturing fluid gel prepared with the crosslinker could perform well under 170°C. Oscillatory shear experiments were conducted to analyze the rheology of the gelation process. Moreover, steady‐state shear and micro‐rheological tests were conducted to analyze the dynamic and static crosslinking process of the fracturing fluid, respectively. Meanwhile, rheo‐kinetic equation was used to fit the data and the effects that various factors had on the gelation process were illustrated thoroughly. This study not only prepared an organic zirconium crosslinker with good performances, but also explored the crosslinking process of fracturing fluid gel, which could improve its further application in oilfields.