bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of auxeticity on mechanical properties of3Dwoven auxetic reinforced thermoplastic composites
Authors: Ullah Tehseen , Hussain Muzzamal , Ali Mumtaz , Umair Muhammad 
Published: November 2022

Abstract3D woven composites are currently used in high‐tech applications due to their better mechanical properties than 2D laminated composites. To further enhance the mechanical performance of 3D woven composites, auxetic structures can be used as reinforcement. The auxetic structures showed better mechanical properties due to bidimensional energy dissipation capability. Orthogonal 3D woven structures showed inherent auxetic nature, however, the use of brittle thermoset resins in composites fully limits their auxeticity. To overcome this issue, three types of 3D woven auxetic structures (warp, weft, and bidirectional interlocks) were developed and used as reinforcement with thermoplastic resins (PC and PVB). Auxeticity of woven reinforcement, and tensile, flexural (3‐point), and short beam shear (SBS) tests of composites were conducted. Auxeticity results revealed that the warp interlock structure showed the highest auxeticity, while the bidirectional interlock structure exhibited the least auxeticity due to the high number of intersections and crimp %. Furthermore, warp interlock composite structure showed 47%, 49.5%, and 37% higher tensile, flexural, and shear strength values, respectively than bidirectional interlock structure in warp direction with PC resin. The overall results showed that auxetic reinforcement improved the mechanical performance of 3D woven composites.
Modulation of TRPV2 by endogenous and exogenous ligands: A computational study
Authors: Feng Shasha , Pumroy Ruth A. , Protopopova Anna D. , Moiseenkova‐Bell Vera Y. , Im Wonpil 
Published: November 2022

AbstractTransient receptor potential vanilloid (TRPV) channels play various important roles in human physiology. As membrane proteins, these channels are modulated by their endogenous lipid environment as the recent wealth of structural studies has revealed functional and structural lipid binding sites. Additionally, it has been shown that exogenous ligands can exchange with some of these lipids to alter channel gating. Here, we used molecular dynamics simulations to examine how one member of the TRPV family, TRPV2, interacts with endogenous lipids and the pharmacological modulator cannabidiol (CBD). By computationally reconstituting TRPV2 into a typical plasma membrane environment, which includes phospholipids, cholesterol, and phosphatidylinositol (PIP) in the inner leaflet, we showed that most of the interacting surface lipids are phospholipids without strong specificity for headgroup types. Intriguingly, we observed that the C‐terminal membrane proximal region of the channel binds preferentially to PIP lipids. We also modelled two structural lipids in the simulation: one in the vanilloid pocket and the other in the voltage sensor‐like domain (VSLD) pocket. The simulation shows that the VSLD lipid dampens the fluctuation of the VSLD residues, while the vanilloid lipid exhibits heterogeneity both in its binding pose and in its influence on protein dynamics. Addition of CBD to our simulation system led to an open selectivity filter and a structural rearrangement that includes a clockwise rotation of the ankyrin repeat domains, TRP helix, and VSLD. Together, these results reveal the interplay between endogenous lipids and an exogenous ligand and their effect on TRPV2 stability and channel gating.
Quantitative structure–properties relationship analysis of Eigen‐value‐based indices using COVID‐19 drugs structure
Authors: Rauf Abdul , Naeem Muhammad , Hanif Asia 
Published: November 2022

AbstractTopological indices are an important method for understanding the fundamental topology of chemical structures. Quantitative structure properties relationship (QSPR) is an analytical approach for breaking down a molecule into a sequence of numerical values that describe the chemical and physical characteristics of the molecule. In this article, we have developed the QSPR analysis between eigenvalue‐based topological indices and physical properties of COVID‐19 drugs to predict the significance level of eigenvalue based indices. We have to use MATLAB for the computation of indices and SPSS for analysis. We show that positive interia index, signless Laplacian Estrada index and Randić energy are the best predictors of molar reactivity, polar surface area and molecular weight, respectively.
A case of anti‐melanoma differentiation‐associated gene 5 antibody‐positive dermatomyositis‐associated rapidly progressive interstitial lung diseases developed after administration of COVID‐19 vaccine and subsequent pneumococcal vaccine
Authors: Takahashi Saeko , Kato Ai , Hashimoto Kanako , Takehara Tomohiro , Ishioka Kota , Takanashi Satoshi 
Published: November 2022

AbstractFive cases of anti‐melanoma differentiation‐associated gene 5 antibody‐positive dermatomyositis‐associated rapidly progressive interstitial lung diseases (anti‐MDA5‐positive DM‐RPILD) following COVID‐19 vaccination have been reported previously. We present the first case of the disease that developed following the sequence of COVID‐19 infection, COVID‐19 vaccination, and 23‐valent pneumococcal polysaccharide vaccine (PPSV23) administration. A 75‐year‐old‐Japanese man received the third dose of Pfizer COVID‐19 vaccine 4 weeks after he had a mild COVID‐19 infection. Eleven weeks after vaccination, he received PPSV23 for the first time. He developed fever, malaise, and anorexia the day after the PPSV23, rash a week later, and shortness of breath 2 weeks later. He was then admitted to a local hospital and treated with antibiotics, but his condition worsened. He was transferred to our hospital 4 weeks after the PPSV23 and was diagnosed with anti‐MDA5‐positive DM‐RPILD. Despite intensive treatment, the patient died on the 10th hospital day.
The hydroclimate niche: A tool for predicting and managing riparian plant community responses to streamflow seasonality
Authors: Butterfield Bradley J. , Palmquist Emily C. , Yackulic Charles B. 
Published: November 2022

AbstractHabitat suitability is a consequence of interacting environmental factors. In riparian ecosystems, suitable plant habitat is influenced by interactions between stream hydrology and climate, hereafter referred to as “hydroclimate”. We tested the hypothesis that hydroclimate variables would improve the fit of ecological niche models for a suite of riparian species using occurrence data from the western United States. We focus on the climate conditions (temperature, precipitation and vapor pressure deficit) during the months of lowest and highest streamflow as integrative hydroclimate metrics of resource and stress levels. We found that the inclusion of hydroclimate variables improved model fit for all species in the western USA dataset. We then tested the utility of the improved habitat suitability models by projecting them onto a regulated segment of the Colorado River to assess potential impacts of streamflow seasonality on vegetation metrics of management concern. Species frequency derived from independent survey data in the Colorado River segment was significantly higher for species with predicted suitable habitat than for species without predicted suitable habitat. Under different simulated hydrographs for the Colorado River, overall species richness was predicted to be greatest with peak streamflows during summer, and native‐to‐non‐native species ratios were predicted to be greatest with lowest streamflows in winter. Summer high flows were particularly associated with higher predicted habitat suitability for species that have increased in cover over recent decades (e.g., Pluchea sericea, Baccharis species). We conclude that hydroclimate covariates can be useful tools for predicting how riparian vegetation communities respond to changes in the seasonal timing of low and high streamflows.
Arsenic mobility and toxicity on soil acid phosphatase activity increased with added phosphorus in contaminated mine soils
Authors: Nurzhan Amanzhan , Tian Haixia , Nuralykyzy Bayan , Li Huayong , Ma Xing , Megharaj Mallavarapu , He Wenxiang 
Published: November 2022

AbstractSoil phosphatase activity is identified as sensitive to arsenic (As) pollution and therefore, often used as an indicator to estimate As toxicity in soil. Nevertheless, the effect of As on soil phosphatase activity after its desorption by P is not adequately studied. This study employed sequential extraction procedure and ecological dose parameters to show As mobility and its toxicity to acid phosphatase (AcP). Results indicated that P application significantly increased As desorption ratio in the As ageing process. In S1 (As 2895 mg kg−1) soil, after P addition, the water‐soluble (FWS) fraction had the highest proportion of As, while for S2 (As 645 mg kg−1) and S3 (As 39 mg kg−1) it was residual (FRES) fraction. Additionally, P addition increased the As bioavailability in all soils. Generally, P addition significantly reduced soil AcP activity under all P concentrations and increased in the soil with minimum As content. The variation partitioning analysis indicated that for S1, P concentration was the major factor, for S2 and S3 soils, it was As desorption and ageing time, respectively, that influenced the AcP activity in soils. The calculated ecological dose (ED50) showed that in most cases, As toxicity increased at the end of ageing. Thus, it is essential to control the phosphorus fertilizer applications in silty soils with acid and neutral pH, since it can lead to increased As mobility and toxicity to soil AcP.
Crohn's disease related strictures in cross‐sectional imaging: More than meets the eye?
Authors: Sleiman Joseph , Chirra Prathyush , Gandhi Namita S. , Baker Mark E. , Lu Cathy , Gordon Ilyssa O. , Viswanath Satish E. , Rieder Florian ,   Stenosis Therapy and Anti‐Fibrotic Research (STAR) Consortium
Published: November 2022

AbstractStrictures in Crohn's disease (CD) are a hallmark of long‐standing intestinal damage, brought about by inflammatory and non‐inflammatory pathways. Understanding the complex pathophysiology related to inflammatory infiltrates, extracellular matrix deposition, as well as muscular hyperplasia is crucial to produce high‐quality scoring indices for assessing CD strictures. In addition, cross‐sectional imaging modalities are the primary tool for diagnosis and follow‐up of strictures, especially with the initiation of anti‐fibrotic therapy clinical trials. This in turn requires such modalities to both diagnose strictures with high accuracy, as well as be able to delineate the impact of each histomorphologic component on the individual stricture. We discuss the current knowledge on cross‐sectional imaging modalities used for stricturing CD, with an emphasis on histomorphologic correlates, novel imaging parameters which may improve segregation between inflammatory, muscular, and fibrotic stricture components, as well as a future outlook on the role of artificial intelligence in this field of gastroenterology.
Formation and structural characterization of the basic tin(II) fluoride, Sn9F13O(OH)3 ⋅ 2H2O, containing the unprecedented [Sn4O(OH)3]3+ cage‐ion
Authors: Uglova Ellina , Reichelt Martin , Reuter Hans 
Published: November 2022

AbstractSingle crystals of the title compound Sn9F13O(OH)3 ⋅ 2H2O, 3, along with those of the oxofluoride Sn4OF6, 2, and the fluorophosphate Sn3(PO4)F3, 1, have been obtained in course of an experiment mimicking the reaction of the tooth paste additive SnF2 with Ca3(PO4)2 as dentin surrogate. All three compounds have been characterized by single crystal X‐ray diffraction. While our data on the crystal structures 1 and 2 confirm previous results but improve bond lengths and angles precision significantly, 3 represents the first example of a basic tin(II) fluoride the structure of which was determined. Its crystal structure consists of bilayers held together through weak secondary Sn⋅⋅⋅F‐bonds while their unsymmetrical, protic‐aprotic monolayers are connected with each other on their protic sites via −OH⋅⋅⋅F‐hydrogen bonds. The most prominent building block of the monolayers constitutes the unprecedented, stella octangula like [Sn4O(OH)3]3+ cage‐ion. The coordination spheres of all nine Sn(II) atoms are analyzed with respect to their constitution, geometry and bonding. The observed bond lengths and bond angles of the tin(II) atoms are interpretated in terms of p‐p‐bonding via 2e–2c bonds (first coordination sphere, {SnX3}, trigonal‐pyramidal) and 4e–3c‐bonds (second coordination sphere, {SnX4}/{SnX5}, seesaw/square‐pyramidal). Bond valence calculations have been found to be of limited benefit to predict the oxidation state of Sn(II) especially when Sn−O bonds are present.
Integrationsrelevante Rahmenbedingungen in den Untersuchungslandkreisen und -gemeinden
Authors: Mehl Peter , Neumeier Stefan , Osigus Torsten 
Published: November 2022

ZusammenfassungDas Kapitel analysiert sozioökonomische Unterschiede in und zwischen unseren Untersuchungsregionen, die wir als integrationsrelevant annehmen. Dabei werden die Ausgangsbedingungen in den Dimensionen „Arbeitsmarkt“, „Wohnraum“, „Bildung“, „Gesundheit“, „Geborgenheit und Sicherheit“, „Wohlstand und kommunale Finanzsituation“ sowie „Demographie“ über Indikatoren erfasst und über deren z-Transformation vergleichbar gemacht. Zusätzlich wird die Erreichbarkeit integrationsrelevanter Orte kleinräumig für verschiedene Verkehrsmittel berechnet.
From Abstract Thinking to Thinking Abstractions: Introducing Speculative Geographies
Authors: Williams Nina , Keating Thomas 
Published: November 2022

AbstractWriting at a time in which speculative ways of thinking appear to be undergoing a reprise across the social sciences and humanities – whether through engagements with speculative cosmology (Stengers, 2006), speculative empiricism (Debaise, 2017), speculative fabulation (Haraway, 2011), speculative research (Wilkie et al., 2017), or speculative realism (Bryant et al., 2011) – in this chapter we introduce Speculative Geographies and our motivation for assembling the collection as a way of considering what concepts and practices of speculation might mean for geography, and how speculation might itself be conceived as geographical. In approaching the relationship between speculation and geography, we introduce the book as a collective desire to complicate the modes of thought used to evaluate experience by crafting alternatives, pluralising perspectives, and thereby problematising the immediately given. Far from abstract thinking, in this chapter we conceptualise speculation, after A.N. Whitehead, as a task of thinking abstractions – a style of thinking that prioritises an openness to what thought might become, and which therefore reconfigures empirical problems beyond what seems given in an immediate experience. The chapter traces key genealogies of this speculative practice including speculative philosophy, speculative fiction, and speculative design. Finally, we provide an overview of how the three themes of the book – ethics, technologies, aesthetics – speak to the chapters making up this edited collection.
Subcritical regime of hybrid inflation with modular A4 symmetry
Authors: Gunji Yoshihiro , Ishiwata Koji , Yoshida Takahiro 
Published: November 2022

Abstract
We consider a supergravity model that has the modular A4 symmetry and discuss the interplay between the neutrino mixing and inflation. The model contains right- handed neutrinos that have the Majorana masses and additional Yukawa couplings to the waterfall field. In the model an active neutrino is massless and we find that only the inverted hierarchy is allowed and the Majorana phase is predicted to be around ±(120–180)° from the observed neutrino mixing data. In the early universe, one of right-handed sneutrinos plays the role of the inflaton field. Focusing on the subcritical regime of the hybrid inflation that is consistent with the cosmic microwave background data, we analyze the dynamics of the scalar sector and derive an upper bound (1010) GeV on the scale of the Majorana mass.
[68Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling
Authors: Zhang Min , Quan Weiwei , Zhu Tianqi , Feng Shuo , Huang Xinyun , Meng Hongping , Du Run , Zhu Zhengbin , Qu Xuezheng , Li Ping , Cui Yuke , Shi Kuangyu , Yan Xiaoxiang , Zhang Ruiyan , Li Biao 
Published: November 2022

Abstract
Purpose
To assess predictive value of 68Ga-labeled fibroblast activation protein inhibitor-04 ([68Ga]Ga-DOTA-FAPI-04) PET/MR for late left ventricular (LV) remodeling in patients with ST-segment elevated myocardial infarction (STEMI).

Methods
Twenty-six patients with STEMI were included in the study. [68Ga]Ga-DOTA-FAPI-04 PET/MR was performed at baseline and at average 12 months after STEMI. LV remodeling was defined as >10% increase in LV end-systolic volume (LVESV) from baseline to 12 months.

Results
The LV remodeling group demonstrated higher [68Ga]Ga-DOTA-FAPI-04 uptake volume (UV) at baseline than the non-LV remodeling group (p < 0.001). [68Ga]Ga-DOTA-FAPI-04 UV at baseline was a significant predictor (OR = 1.048, p = 0.011) for LV remodeling at 12 months after STEMI. Compared to clinical information, MR imaging and cardiac function parameters at baseline, [68Ga]Ga-DOTA-FAPI-04 UV demonstrated better predictive ability (AUC = 0.938, p < 0.001) for late LV remodeling, with sensitivity of 100.0% and specificity of 81.3%.

Conclusions
[68Ga]Ga-DOTA-FAPI-04 PET/MR is an effective tool to non-invasively quantify myocardial fibroblasts activation, and baseline [68Ga]Ga-DOTA-FAPI-04 UV may have potential predictive value for late LV remodeling.
Incidence and predictors for chemotherapy modifications and their impact on the outcome of ovarian cancer patients
Authors: Hatsy Sandra , Brambs Christine , Kiechle Marion 
Published: November 2022

Abstract
Purpose
Chemotherapy (CTX) is an important part of the treatment strategy of stage II–IV ovarian cancer. CTX modifications, such as delays, dose reductions or premature terminations might have a negative impact on overall survival (OS) and progression free survival (PFS). The goal of this study was to determine the incidence and predictors of CTX modifications and their influence on survival.

Methods
An observational retrospective cohort analysis of 192 ovarian cancer patients who were treated at the Department of Obstetrics and Gynaecology, Technical University Munich, Germany, according to international guidelines was performed including from 2009 to 2013. A potential association between patient and disease characteristics and CTX modifications was tested with multivariate logistic regression. OS and PFS were estimated by Kaplan–Meier analysis.

Results
44.8% (86/192) received a modification of CTX. 34 (17.7%) women discontinued CTX prematurely, 17 (8.9%) underwent a dose reduction, 16 (8.3%) experienced a CTX delay and 10 (5.2%) had both a delay and a dose modification. In nine (4.7%) patients, the dose needed to be divided. Leukopenia (p < 0.001) and anaemia (p = 0.003) were significantly more common in patients with CTX modifications. Significant predictors for CTX modifications were a history of thrombosis or embolism (p < 0.001) and residual tumour postoperatively (p = 0.003).
Patients with CTX modifications showed a significantly lower OS as well as PFS (p < 0.001), even after adjustment for prognostic factors such as age, body-mass-index, residual tumour, histology, FIGO stage and grading (p = 0.005 for OS and p = 0.001 for PFS).

Conclusion
CTX modifications have a negative impact on survival. Significant predictors for such modifications are a history of thrombosis or embolism and the presence of residual postoperative tumour. Further studies are needed to avoid CTX modifications and to improve survival of ovarian cancer patients.
The invasion history of Elodea canadensis and E. nuttallii (Hydrocharitaceae) in Italy from herbarium accessions, field records and historical literature
Authors: Buldrini Fabrizio , Pezzi Giovanna , Barbero Martina , Alessandrini Alessandro , Amadei Lucia , Andreatta Sebastiano , Ardenghi Nicola Maria Giuseppe , Armiraglio Stefano , Bagella Simonetta , Bolpagni Rossano , Bonini Ilaria , Bouvet Daniela , Brancaleoni Lisa , Brundu Giuseppe , Buccheri Massimo , Buffa Gabriella , Ceschin Simona , Chiarucci Alessandro , Cogoni Annalena , Domina Gianniantonio , Forte Luigi , Guarino Riccardo , Gubellini Leonardo , Guglielmone Laura , Hofmann Nicole , Iberite Mauro , Lastrucci Lorenzo , Lucchese Fernando , Marcucci Rossella , Mei Giacomo , Mossetti Umberto , Nascimbene Juri , Passalacqua Nicodemo Giuseppe , Peccenini Simonetta , Prosser Filippo , Repetto Giovanni , Rinaldi Gabriele , Romani Enrico , Rosati Leonardo , Santangelo Annalisa , Scoppola Anna , Spampinato Giovanni , Stinca Adriano , Tavano Maria , Tomsich Caruso Fulvio , Vangelisti Roberta , Venanzoni Roberto , Vidali Marisa , Wilhalm Thomas , Zonca Francesco , Lambertini Carla 
Published: November 2022

AbstractWe analysed the invasion history of two North American macrophytes (Elodea canadensis and E. nuttallii) in Italy, through an accurate census of all available herbarium and field records, dating between 1850 and 2019, and a rich literature collection describing the initial introduction and naturalisation phase that supports the results obtained by the occurrence records. Elodea canadensis arrived in Italy before 1866 and had two invasion phases, between the 1890s and 1920s and between the 1990s and 2000s; E. nuttallii, probably arrived in the 1970s, started invading in 2000 and the invasion is still ongoing. Botanical gardens and fish farming played a crucial role in dispersal and naturalisation of both species. The current invasion range of both species is centred in northern Italy, with scattered occurrences of E. canadensis in central and southern regions. River Po represents a dispersal barrier to the Mediterranean region and a strategic monitoring site to prevent the invasion in the peninsula. The study detects differences in the niches of the two species during the introduction and naturalisation phase and a habitat switch occurred after 1980 in E. canadensis and after 2000 in E. nuttallii, during their expansion phases. For E. canadensis the switch corresponds to the second invasion round. Further research can clarify whether the second invasion round is due to confusion of the recently introduced E. nuttallii with E. canadensis, to a cryptic introduction of a new genotype, to post-introduction evolution, or just to an increased scientific interest in biological invasions.