bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prepectoral Breast Reconstruction Reduces Opioid Consumption and Pain After Mastectomy
Authors: Holland Michael , Su Paul , Piper Merisa , Withers Jacquelyn , Harbell Monica W. , Bokoch Michael P. , Sbitany Hani 
Published: October 2022

Background
Acute pain after mastectomy is increased with concurrent breast reconstruction. One postulated advantage of prepectoral breast reconstruction is less postoperative pain; however, no comparisons to partial submuscular reconstruction have been made to date. Here, we examined the postoperative pain experienced between patients with prepectoral and subpectoral breast reconstruction after mastectomy.

Methods
We performed a retrospective chart review of all patients undergoing immediate breast reconstruction with tissue expanders from 2012 to 2019 by a single plastic surgeon. Patient demographics, surgical details, and anesthetic techniques were evaluated, and our primary outcome compared postoperative opioid usage between prepectoral and subpectoral reconstructions. Our secondary outcome compared pain scores between techniques.

Results
A total of 211 subpectoral and 117 prepectoral reconstruction patients were included for analysis. Patients with subpectoral reconstructions had higher postoperative opioid usage (80.0 vs 45.0 oral morphine equivalents, P < 0.001). Subpectoral patients also recorded higher maximum pain scores compared with prepectoral reconstructions while admitted (7 of 10 vs 5 of 10, P < 0.004). Multivariable linear regression suggests that mastectomy type and subpectoral reconstruction were significant contributors to postoperative opioid use (P < 0.05).

Conclusions
Prepectoral breast reconstruction was associated with less postoperative opioid consumption and lower postoperative pain scores as compared with subpectoral reconstruction, when controlling for other surgical and anesthesia factors. Future randomized controlled trials are warranted to study how postoperative pain and chronic pain are influenced by the location of prosthesis placement in implant-based postmastectomy breast reconstruction.
An analysis of the meta-analysis of board characteristics and demand for audit quality
Authors: Yang Zhifeng 
Published: October 2022

PurposeThe purpose of this study is to discuss Kalia, Basu and Kundu's (KBK’s) paper's motivation, findings and contributions and suggest further development.Design/methodology/approachThis paper is to discuss the meta-analysis of board characteristics and demand for audit Quqality by KBK.FindingsKBK paper is well motivated and makes new contributions to the literature. Future research can expand the sample and examine the moderating effects of institutional factors such as ownership structure, regulatory reforms and country-level investor protection and legal enforcement.Originality/valueBased on the review of KBK’ spaper, this study suggests that future research should expand the sample and examine the moderating effects of institutional factors such as ownership structure, regulatory reforms and country-level investor protection and legal enforcement.
Extrinsic and intrinsic motives: panic buying and impulsive buying during a pandemic
Authors: Lavuri Rambabu , Jaiswal Deepak , Thaichon Park 
Published: October 2022

PurposeThe present study operationalizes and tests the impact of extrinsic (store environment, promotional activities) and intrinsic (hedonism, materialism) variables on impulsive buying during the COVID-19 period. It also considers the dual-factor approach (panic and impulsive buying tendency) using the “Stimulus-Organism-Response” approach and “Dual-Factor Theory”.Design/methodology/approachPurposive sampling was used to obtain data from 362 responses from retail shoppers and analyzed by path analysis. The moderation of novel constructs (scarcity and COVID-19 pandemic) examines the backdrop of retail impulse shopping.FindingsThe store environment has a detrimental effect on panic and impulsive buying. Promotional activities have a beneficial effect on impulsive buying tendency. Similarly, hedonism and materialism have a substantial positive effect on panic and impulsive buying tendencies. Between stimulus (intrinsic and extrinsic) and response variables, organism factors (panic and impulsive buying inclinations) influenced positively (impulsive buying); in terms of moderation, scarcity and the COVID-19 pandemic exhibit substantial moderation between organism and response.Originality/valueThe results contribute substantially to the existing domain of customers’ panic and impulsive purchasing behavior for the scarcity of essential items during the COVID-19 epidemic. Research in this field is limited, varied and inconclusive. New insights were obtained as this research blends the “Stimulus-Organism-Response” and Dual factor theories.
Workplace loneliness, ego depletion and cyberloafing: can leader problem-focused interpersonal emotion management help?
Authors: Yang Hongling , Lin Zhibin , Chen Xiao , Peng Jian 
Published: October 2022

PurposeThis study aims to explore whether and how workplace loneliness leads to cyberloafing and the role of leader problem-focused interpersonal emotion management in buffering this relationship.Design/methodology/approachDrawing on ego depletion theory, the authors propose that employees' workplace loneliness leads to cyberloafing via ego depletion, while leader interpersonal emotion management (i.e. leadership behavior targeted at managing employees' negative emotions) can help to alleviate the situation. To test this study’s predictions, the authors collected multisource data at three time points from a sample of 219 employee–colleague dyads.FindingsThe results show that workplace loneliness is positively related to cyberloafing and that ego depletion mediates this relationship. Leader problem-focused interpersonal emotion management weakens the relationship between workplace loneliness and ego depletion and the indirect relationship between workplace loneliness and cyberloafing via ego depletion such that the above relationships are weak (versus strong) when leader problem-focused interpersonal emotion management is high (versus low).Originality/valueThe study results suggest that workplace loneliness is an important hidden danger that leads to cyberloafing because lonely employees suffer more from ego depletion. Leaders' interpersonal emotion management strategy serves as a potential buffer for such a negative effect.
Popping the “bubble” metaphor: separation and integration of expatriate communities
Authors: Miao Chengcheng , Gaggiotti Hugo , Brewster Chris 
Published: October 2022

PurposeThis paper aims to discuss multiple uses of the concept of “bubble” as a metaphor to refer to different experiences of foreign working communities and suggests a more flexible and comprehensive approach.Design/methodology/approachBased on ethnographic fieldwork conducted at different locations, the authors propose changing the use of the bubble metaphor from an analogy of living in isolation to a way of conceptualising the changing contexts and characteristics that impact the porosity and permeability of communities.FindingsThe paper suggests that when using the metaphor as a concept, the following considerations need to be taken into account: (1) the conventional thinking that “expat-bubbles” are isolated places, (2) any simplistic notion that different internationally mobile workers will be less or more immersed in the local community and (3) the use of the bubble metaphor without a careful delineation and reference to its permeability and porosity.Originality/valueThe paper helps to visualise a different dimension of the traditional taken-for-granted representation of the bubble. The bubble emerges as a rich analogical concept not to explain binomial representations of integration-separation. Rather than a simple “open” or “closed”, bubbles became more or less porous and permeable depending on the experiences of foreign working communities.
An exploration of LAF‐bTMB as a predictor for the efficacy of immunotherapy combined with chemotherapy in non—small cell lung cancer
Authors: Zhang Shuyang , Yang Lu , Yang Yaning , Xin Ying , Wang Yan 
Published: October 2022

AbstractBackgroundImmune checkpoint inhibitor (ICI) combined with chemotherapy is one of the standards of care for advanced non–small cell lung cancer (NSCLC) without driver mutations. However, the biomarker of combination therapy is still unknown. Although previous studies have confirmed that low allele frequency adjusted blood‐based tumor mutational burden (LAF‐bTMB) is associated with the efficacy of ICI monotherapy, there has been no report on the correlation between the efficacy of LAF‐bTMB and ICI combined chemotherapy. This study aimed to explore whether LAF‐bTMB can be used as a predictive biomarker for the efficacy of immunotherapy combined with chemotherapy in advanced NSCLC.MethodsThis study enrolled patients diagnosed with advanced NSCLC and who received ICI combined with chemotherapy for first‐line therapy from May 2020 to December 2021 at Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. Clinical information, treatment information, survival data, and peripheral blood samples of every patient before treatment were collected. Next‐generation sequencing was performed on plasma samples to estimate bTMB and LAF‐bTMB.ResultsA total of 42 patients with NSCLC were enrolled. In this cohort, 19 patients achieved partial response (PR), and the objective response rate (ORR) was 45.2%. The median progression‐free survival (PFS) of all patients was 13.4 months (95% CI, 7.49–19.72). Both PFS and the overall survival (OS) were significantly longer in the responder (R) group than in the non‐responder (NR) group (median PFS, 16.4 months vs. 7.2 months, p = 0.028; median OS, NE vs. 9.3 months, p = 0.016). There was no significant difference in bTMB and LAF‐BTMB between the R and NR group. The ORR of patients with LAF‐bTMB≤8muts/Mb was significantly higher than that of patients with LAF‐bTMB >8muts/Mb (ORR, 61% vs. 26%, respectively, p = 0.033). When LAF‐bTMB ≤8muts/Mb or > 20muts/Mb, ORR was significantly higher than that of patients with LAF‐bTMB between 8 and 20muts/Mb (ORR were 57% and 21%, p = 0.047). No correlation has been found between LAF‐bTMB and PFS or OS.ConclusionsThis study confirmed that neither bTMB nor LAF‐bTMB is feasible as a potential predictor of first‐line immunochemotherapy for advanced NSCLC. More suitable biomarkers need to be explored to screen patients with better efficacy of immunotherapy combined with chemotherapy in the future.
Investigation of poor predictive factors in extensive stage small cell lung cancer under etoposide‐platinum‐atezolizumab treatment
Authors: Lim Jeong Uk , Kang Hye Seon , Shin Ah. Young , Yeo Chang Dong , Kim Sung Kyoung , Kim Jin Woo , Kim Seung Joon , Lee Sang Haak 
Published: October 2022

AbstractBackgroundThe phase III trial IMpower133 showed that platinum and etoposide plus atezolizumab was associated with improved overall survival (OS) and progression free‐survival (PFS) when compared to the placebo group in treatment‐naïve extensive stage (ES) small cell lung cancer (SCLC). Due to superiority in clinical outcomes, combination immunotherapy plus chemotherapy have become mainstay treatment modalities as first‐line treatment in ES‐SCLC. Nevertheless, real‐world data are still lacking and the search for potential biomarkers is essential. This study aimed to evaluate potential predictive biomarkers applicable in ES‐SCLC under combination therapy.MethodsPatients with ES‐SCLC under etoposide‐platinum‐atezolizumab enrolled from seven university hospitals affiliated to the Catholic University of Korea were evaluated. Pretreatment clinical parameters were evaluated for association with OS and PFS. Adverse events (AEs) during induction and maintenance phases were also evaluated. p‐values below 0.05 were considered statistically significant.ResultsA total of 41 patients were evaluated. Six‐month survival was 68.6%. As best response to treatment, 26 (63.4%) showed partial response, nine (22.0%) showed stable disease, and four (9.8%) showed progressive disease. During the induction phase, grade I–II AEs occurred in 22 (53.7%) patients, and grade III–IV AEs occurred in 26 (63.4%) patients. During the maintenance phase, nine out of 25 (36.0%) patients experienced any grade AEs. In multivariate analysis for OS, lactate dehydrogenase (LDH), c‐reactive protein (CRP), and forced vital capacity (%) were significant factors. In multivariate analysis for PFS, sex, and LDH were significant.ConclusionIn ES‐SCLC under etoposide‐platinum‐atezolizumab, pretreatment CRP, LDH and FVC (%) were independent predictive factors.
An analysis of silybin meglumine tablets in the treatment of drug‐induced liver injury as assessed for causality with the updated Roussel Uclaf Causality Assessment Method using a nationwide database
Authors: Zhang Bo , Jiang Guosheng , Wang Li , Li Xia , Zhao Chuan , Tan Qiliang , Kang Weiwei , Feng Yuxia , Han Xian , Raza Hafiz Khuram , Mao Yimin 
Published: October 2022

AimDrug‐induced liver injury (DILI) poses significant challenges to clinical practice. Currently, there is no recommended therapy to treat DILI; therefore, it is vital to explore new therapeutic agents. This study aimed to investigate the efficacy and safety of silybin meglumine tablets in treating DILI.MethodsThis study analysed 34 296 DILI cases assessed by the updated RUCAM from a nationwide database. A total of 301 patients with RUCAM scores ≥6 were directly enrolled in this study, while an additional 340 patients with RUCAM scores <6 who were adjudged as probable DILI by a panel of three hepatologists were also included in the analysis. The enrolled patients were divided into the silybin meglumine group and the control group. The propensity score matching (PSM) method was used to obtain comparable characteristics between the two groups.ResultsThere were 129 cases in the silybin meglumine group and 512 cases in the control group. After applying PSM, 129 matched pairs were obtained. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) resumption rates in the silybin meglumine group were significantly higher than the control group (58.91% vs. 20.93%, P ≤ .0001 and 63.49% vs. 37.50%, P ≤ .0001). The univariate and multivariate logistic regression analysis revealed that grouping factor (odds raio [OR], 5.42; 95% confidenxe interval [CI], 3.12–9.39; P < .0001 and OR, 6.10; 95% CI, 2.98–12.48; P < .0001) and ALT levels (OR, 0.95; 95% CI, 0.93–0.98; P = .0015 and OR, 0.95; 95% CI, 0.92–0.99; P = .0157) were essential influencing factors for ALT normalization.ConclusionsSilybin meglumine tablets are safe and effective in DILI treatment. Large‐scale and randomized controlled trials are required to further confirm their efficacy.
Sex disparities in medication prescribing amongst patients with type 2 diabetes mellitus managed in primary care
Authors: Ambrož Martina , Geelink Marit , Smits Kirsten P.J. , de Vries Sieta T. , Denig Petra 
Published: October 2022

AbstractBackgroundSex differences in clinical outcomes have been observed for patients with type 2 diabetes mellitus (T2DM). These could be related to sex disparities in treatment.ObjectivesTo determine whether there are sex disparities in medication prescribing amongst patients with T2DM.MethodsA cohort study was conducted using the Groningen Initiative to ANalyze Type 2 diabetes Treatment (GIANTT) database, which includes data from primary care patients with T2DM from the north of the Netherlands. Data on demographics, physical examinations, laboratory measurements and prescribing were extracted. A set of validated prescribing quality indicators assessing the prevalence, start, intensification and safety of glucose‐, lipid‐, blood pressure‐ and albuminuria‐lowering medication was applied for the calendar year 2019. Univariate logistic regression analyses were conducted.ResultsWe included 10,456 patients (47% females). Females were less often treated with metformin (81.7% vs. 86.5%; OR 0.70, 95% CI 0.61–0.80), and were less often prescribed a renin‐angiotensin‐aldosterone inhibitor (RAAS‐i) when treated with multiple blood pressure‐lowering medicines (81.9% vs. 89.3%; OR 0.55, 95% CI 0.46–0.64) or when having albuminuria (74.7% vs. 82.1%; OR 0.64, 95% CI 0.49–0.85) than males. Statin treatment was less frequently started (19.7% vs. 24.7%; OR 0.75, 95% CI 0.58–0.96) and prescribed (58.7% vs. 63.9%; OR 0.80, 95% CI 0.73–0.89) in females. There were no differences in starting and intensifying glucose‐, blood pressure‐ and albuminuria‐lowering medication.ConclusionsSex disparities in medication prescribing amongst T2DM patients were seen, including less starting with statins and potential undertreatment with RAAS‐i in females. Such disparities may partly explain higher excess risks for cardiovascular and renal complications associated with diabetes observed in females.
Coordination of photosynthetic traits across soil and climate gradients
Authors: Westerband Andrea C. , Wright Ian J. , Maire Vincent , Paillassa Jennifer , Prentice Iain Colin , Atkin Owen K. , Bloomfield Keith J. , Cernusak Lucas A. , Dong Ning , Gleason Sean M. , Guilherme Pereira Caio , Lambers Hans , Leishman Michelle R. , Malhi Yadvinder , Nolan Rachael H. 
Published: October 2022

Abstract“Least‐cost theory” posits that C3 plants should balance rates of photosynthetic water loss and carboxylation in relation to the relative acquisition and maintenance costs of resources required for these activities. Here we investigated the dependency of photosynthetic traits on climate and soil properties using a new Australia‐wide trait dataset spanning 528 species from 67 sites. We tested the hypotheses that plants on relatively cold or dry sites, or on relatively more fertile sites, would typically operate at greater CO2 drawdown (lower ratio of leaf internal to ambient CO2, Ci:Ca) during light‐saturated photosynthesis, and at higher leaf N per area (Narea) and higher carboxylation capacity (Vcmax 25) for a given rate of stomatal conductance to water vapour, gsw. These results would be indicative of plants having relatively higher water costs than nutrient costs. In general, our hypotheses were supported. Soil total phosphorus (P) concentration and (more weakly) soil pH exerted positive effects on the Narea–gsw and Vcmax 25–gsw slopes, and negative effects on Ci:Ca. The P effect strengthened when the effect of climate was removed via partial regression. We observed similar trends with increasing soil cation exchange capacity and clay content, which affect soil nutrient availability, and found that soil properties explained similar amounts of variation in the focal traits as climate did. Although climate typically explained more trait variation than soil did, together they explained up to 52% of variation in the slope relationships and soil properties explained up to 30% of the variation in individual traits. Soils influenced photosynthetic traits as well as their coordination. In particular, the influence of soil P likely reflects the Australia's geologically ancient low‐relief landscapes with highly leached soils. Least‐cost theory provides a valuable framework for understanding trade‐offs between resource costs and use in plants, including limiting soil nutrients.
Alpine tectono‐metamorphic evolution of the Corsica basement
Authors: Rossetti Federico , Cavazza William , Di Vincenzo Gianfranco , Lucci Federico , Theye Thomas 
Published: October 2022

AbstractThe Alpine orogenic edifice of Corsica (northern Tyrrhenian Sea) offers the possibility to investigate the mode through which continental crust responds to the propagation of regional shortening at convergent plate margins. The geology of Corsica has been traditionally described as separating domains affected by the Alpine tectonism (Alpine Corsica) from those that did not experience the Alpine tectono‐metamorphic overprint (Hercynian Corsica), but recent studies show that most of Hercynian Corsica was thermally reset in post‐Eocene times, questioning this paradigm. The continental units formed at the expenses of the stretched continental margin of the European plate and consist of Hercynian granitoid basement rocks and cover sequences (Permian volcaniclastics and Mesozoic sedimentary successions). By integrating meso‐ and microstructural investigations with metamorphic thermobarometry and 40Ar–39Ar geochronology along three E–W trending structural transects running across the basement section exposed below the Alpine orogenic wedge, we document middle‐late Eocene (c. 50–33 Ma) westward‐verging syn‐metamorphic (low‐grade blueschist facies) thick‐skinned, basement‐involved thrusting. Significantly, crustal shortening in the continental basement predated of c. 15–10 Ma the subduction zone metamorphism in the oceanic‐derived Schistes Lustrés Complex. When the P–T–t–deformation history as reconstructed from the Corsica basement is integrated with the regional scenario of the Alpine–Apennine orogeny, a tectonic reconstruction is proposed, which frames the Alpine orogeny in Corsica within the Apennine–Maghrebian subduction system in the retroside (retrowedge) of the Apennine orogenic wedge.
Mincy mesosiderite metallic nodules analyzed byEBSD: An approach to understanding their thermal history
Authors: García Laura Noel , Varela María Eugenia , Hwang Shyh‐Lung , Shen Pouyan , Bolmaro Raúl , Ávalos Martina 
Published: October 2022

AbstractMeteorites carry information about the most common processes that have been active in the early solar system. In particular, mesosiderites are meteorites with a structure considered to be composed of equal parts of iron–nickel metal and silicates. A natural delimitation in the study of such complex systems is the discrimination of the iron–nickel metallic and silicate domains. In this work, we focus on the metallic phases of the Mincy mesosiderite, a specimen available at the Instituto de Ciencias Astronómicas, de la Tierray y del Espacio repository. In Mincy, the metallic phases are iron–nickel–carbon alloys that are distributed forming metallic lumps or pebbles (referred to as metallic nodules in the article) in which kamacite and taenite are present, and taenite is found both at the kamacite/silicate interface and surrounded by kamacite, that is, isolated from the silicates. We made use of the electron backscattered diffraction technique to determine the crystallographic orientation relationships along the taenite/kamacite boundaries as well as for characterizing the (hkl)‐specific grain boundaries regarding the underlying tilt, twist, or twinning mechanism to assist the interpretation of the phase transformations and mechanisms that could explain the formation of these metallic nodules. From the results, each of the metallic nodules has a unique temperature–pressure history and kinetics to undergo phase transformations (mainly partial melting, heterogeneous nucleation‐controlled solidification, and possible evaporation–condensation) as well as liquid‐phase sintering and recrystallization in its own way.