bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levetiracetam or Phenobarbitone as a First-Line Anticonvulsant in Asphyxiated Term Newborns? An Open-Label, Single-Center, Randomized, Controlled, Pragmatic Trial
Authors: Susnerwala Sukena , Joshi Amol , Deshmukh Laxmikant , Londhe Atul 
Published: June 2022

BACKGROUND AND OBJECTIVE
Neonatal seizures are one of the most challenging problems for experts across the globe. Although there is no consensus on the “ideal” treatment of neonatal seizures, phenobarbitone has been the drug of choice for decades. Unfortunately, although extensively studied in adults and children, levetiracetam lacks rigorous evaluation in the neonatal population, despite its frequent use as an off-label drug. The objective of this open-label, randomized, active-control, single-center, pragmatic trial was to compare the effectiveness of levetiracetam with phenobarbitone for term asphyxiated infants as a first-line drug.

METHODS
The participants included in this study were inborn term asphyxiated infants with seizures in the first 48 hours of life. Infants satisfying the inclusion criteria were randomized to receive levetiracetam (20 mg/kg) or phenobarbitone (20 mg/kg). Clinical seizure control was noted. Infants who failed to respond to the primary drug were given the other group drug.

RESULTS
Of 103 eligible infants, 82 were randomly assigned (44 levetiracetam group, 38 phenobarbitone group). Clinical seizure control with the primary drug and maintenance of the same for 24 hours was observed in 29 infants (65.9%) in the levetiracetam group and 13 infants (34.2%) in the phenobarbitone group (P &lt; .05, relative risk 0.52, 95% confidence interval 0.32–0.84). Of the infants in the phenobarbitone group who did not respond to the primary drug, 57.8% were controlled after adding levetiracetam.

CONCLUSION
Levetiracetam can be used with effectiveness as a first- and second-line drug in asphyxiated term infants. A more extensive study on pharmacokinetics and optimal regimen is required.
A rare case of disseminated pulmonary ossification associated with fibrotic lung disease
Authors: Kumar Manish , Singh Priya 
Published: June 2022

Abstract
Disseminated pulmonary ossification (DPO) is a rare disease characterised by diffuse calcification/ossification of lung parenchyma. Most of the cases are idiopathic, while rest of the cause may have underlying cause like lung congestion, lung injury, lung amyloidosis and interstitial lung disease (ILD). We present a rare case of 58-year-old women with progressive dyspnoea and dry cough. On CT, there were extensive confluent nodular and linear calcification of bilateral lung parenchyma associated with lung fibrosis. Imaging findings lead to diagnosis of DPO associated with idiopathic lung fibrosis. Development of such calcification in ILD is very unusual, therefore knowledge of imaging features of DPO is very crucial for its diagnosis.
La convivencia escolar y la calidad educativa en educación primaria
Authors: Valbuena-Núñez Claudia Helena 
Published: June 2022

El estudio se introduce en la convivencia escolar porque parte de los valores desarrollados en épocas recientes encontrándose la ausencia de estrategias educativas como punto crítico, motivado a la baja inversión de recursos en la educación, que son puntuales para lograr un desarrollo humano pleno. Ello significa que existen limitaciones macros, que actúan de forma silenciosa, porque destruyen la esencia del ser humano en su dignidad, lo someten a la discriminación, xenofobia y demás males que emergen ahora en este siglo XXI, como consecuencia de las continuas migraciones existentes en los diferentes países de la Región por una grave situación económica, social, política, ambiental, tecnológica entre otras. El objetivo es desarrollar un análisis reflexivo sobre la importancia de la convivencia escolar y su incidencia en los procesos de calidad educativa en los estudiantes del nivel de educación primaria de Colombia. La metodología es cualitativa con sustento en una revisión documental/bibliográfica de varios artículos científicos, así como el análisis de datos procedentes de instituciones educativas públicas de Bogotá, Colombia según fuentes documentales. Los resultados son que el flagelo del hambre y la violencia se han acentuado, específicamente en el sector educativo, a tal punto que las ayudas que se han incorporado por organizaciones no gubernamentales sin fines de lucro no han satisfecho la demanda creciente de estas regiones, que están en la desidia y en completa marginalización. Las conclusiones son que existen limitaciones de orden pedagógico para la mejora oportuna de la calidad educativa y la convivencia escolar.
The problem of rare tumors in gynecology: a clinical case of benign retroperitoneal sclerosing pelvic pecoma in 49-year-old woman
Authors: Lanchinsky V. I. , Chushkov Yu. V. , Ponomarev A. B. , Osmanov Yu. I. , Ishchenko A. I. , Vorobev N. V. 
Published: June 2022

The tumor lesions of the reproductive system organs carry the leading position in the structure of gynecological diseases. One of the rare tumors that can affect the organs of the reproductive system is pecoma, which is a tumor of mesenchymal origin. Because of it’s rare occurrence the gynecologists often misinterpret available clinical data and the results of patient`s examination, diagnosing and treating the tumor as a myoma before having received the results of the histological examination. Our article describes a clinical case of a patient who had a preliminary diagnosis of uterine fibroids, and because of this fact the planned surgical treatment was carried out. But a retroperitoneal tumor originating from the uterine vein was detected during the surgery. The diagnosis of sclerosing pecoma was established by histological and immunohistochemical studies. The article analyzes the clinical features of the patient`s disease, as well as the available results of instrumental methods of examination which can lead to final diagnosis of pecoma, also difficult issues of diagnosis and tactics of diagnostic search are noted.The literature data on the frequency of detection of pecomas, the features of their structure are presented. It is marked, that there is also a possibility of pecoma`s localization in various organs, for example, lungs, liver, kidneys, as well as in soft tissues. The possibility of multiple lesions – pecomatosis is emphasized. It is noted that among the pelvic organs the uterus is affected most often, but furthermore, the pelvic lymph nodes, the broad ligament, the omentum, the peritoneum of the pelvis and the rectum wall can be also involved in the pathological process. Risk factor of pecomas malignancy is discussed separately, the presence of three types of pecomas is determined. This fact significantly effects the probability of relapse of the tumor after surgical removal and, respectively, the tactics of postoperative follow‑up of such patients.
Study of biological activity of 2-quinoline-2-yl-derivative 1,3-tropolone in experiment
Authors: Lukbanova E. A. , Dzhenkova E. A. , Goncharova A. S. , Maksimov A. Yu. , Komarova E. F. , Minkin V. I. , Sayapin Yu. A. , Gusakov E. A. , Kurbanova L. Z. , Kiblitskaya A. A. , Zaikina E. V. , Mindar M. V. , Voloshin M. V. , Shaposhnikov A. V. , Lysenko I. B. , Nikolaeva N. V. 
Published: June 2022

Purpose of the study. Was to reveal the antitumor effect of 2‑(6,8‑dimethyl‑5‑nitro‑4‑chloroquinoline‑2‑yl)‑5,6,7‑trichloro‑1,3‑tropolone in subcutaneous PDX models of human lung cancer.Material and methods. The studied tropolone was synthesized using a method of expanding the o‑quinone cycle. Assess to it’s toxic effects was given by the survival and changes in the health status of female Balb/c Nude mice. Antitumor tropolone effects were studied in subcutaneous patient‑derived xenograft (PDX) models of human squamous cell lung cancer in Balb/c Nude mice. The average volumes of tumor nodes and tumor growth inhibition (TGI %) rate were taken into account. Biochemical blood tests and histological analysis of the tumor material were performed in recipient mice.Results. An analysis of acute tropolone toxic effects did not reveal the lethal dose. The maximal TGI was observed on day 36 of the experiment in group 5 which have received 2.75 mg/g tropolone and accounted 73.5 % for females and 74.4 % for males. The average tumor volumes in females of this group were 431.3 ± 1,1 mm3 on day 33 of the experiment, in males – 428.9 ± 1,7 mm3 on day 30, and then the tumor volumes declined. The biochemical analysis of blood and histological examination of the tumor tissue of recipient mice reflect the severity of the antitumor effect on the dose of the studied tropolone.Conclusion. The research demonstrated the antitumor activity of 2‑(6,8‑dimethyl‑5‑nitro‑4‑chloroquinoline‑2‑yl)‑5,6,7‑trichloro‑1,3‑tropolone against subcutaneous PDX models of human NSCLC. The revealed tendencies can be used to search for effective modes of the compound application in clinical practice.
Magnetic resonance imaging in terms of observation of patients after transanal resections of rectal tumors
Authors: Myalina S. A. , Berezovskaya T. P. , Nevolskikh A. A. , Avdeenko V. A. , Ivanov S. A. , Kaprin A. D. 
Published: June 2022

Purpose of the study. Was to study the results of magnetic resonance imaging (MRI) of the patients with malignant neoplasms (MN) of the rectum after transanal full‑layer resection of the tumor.Materials and methods. MRI images of the pelvis of 25 patients with rectal cancer after organ–preserving surgical treatment in the volume of full‑layer excision of the tumor for the period from 2015 to 2020 of the MRI department of the A. Tsyb Medical Radiological Research Centre, the Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; 13 patients received additional treatment in the volume of chemoradiotherapy and brachytherapy; 13 patients underwent dynamic studies to assess the process after treatment.The MRI picture was evaluated by T2‑WI in three planes and DWI with an ADC map in the pelvic region and aimed at the excision zone of the tumor.Indications for MRI were the exclusion of continued tumor growth in the surgical intervention area and clinical manifestations of suture failure in the tumor excision area.Results. All patients were divided into two groups: 11 patients with a normal course of the postoperative period where visualized a zone of scar changes in the area of surgical intervention with a low intensity signal in the T2‑WI mode, without signs of true diffusion restriction, hyper‑ and the average intensity of the signal and 14 patients with identified deviations from the normal picture: of these 10 patients with a relapse after surgical treatment, who had additional formations with signs of pathological MR signal, true diffusion restriction, which were regarded as recurrent formations in the tumor excision zone, as well as 4 patients in the tumor excision zone, a defect in the rectal wall was visualized against the background of a low intensity signal from the zone of fibrous changes, with the formation of liquid leaks, indicating the insolvency of the seams.Conclusion. The method of MRI can be recommended as the method of choice for assessing the pelvic region after transanal endoscopic microsurgery (TEM), which allows for high accuracy to exclude continued tumor growth; to assess the pelvic region for the presence of distant metastases; to determine the defect of the walls in the excision zone of tumors. MRI provides safe dynamic control.
Prognostic value of matrix metalloproteinases and transforming growth factor – β in kidney cancer
Authors: Tarasenko A. I. , Rossolovskiy A. N. , Berezinets O. L. , Bucharskaya A. B. , Pakhomiy S. S. , Efimova A. O. , Maslyakova G. N. 
Published: June 2022

Purpose of the study. The study's objective is to investigate the expression level of tissue and serum markers of oncogenesis and nephrofibrosis transforming growth factor beta (TGF‑β) and matrix metalloproteinase‑9 (MMP‑9) in patients operated for various stages of renal cell carcinoma.Materials and methods. The study prospectively included medical data of 60 patients with kidney cancer with T1–3N0M0 who received surgical treatment in the Clinic of Urologynamed after S. R. Mirotvortsev of the State Medical University from 2016 to 2019. The patients were divided into 3 groups: Group 1 included 20 patients who underwent laparoscopic kidney resection; Group 2–20 patients who underwent laparoscopic nephrectomy; Group 3–20 patients who underwent open nephrectomy. The control group consisted of 15 healthy volunteers without chronic kidney diseases. All patients signed an informed consent to participate in the study. All patients at the preoperative stage, in the early (7–10 days) and remote postoperative periods (after 1 and 2 years) were tested by solid‑phase ELISA on a StatFax 4200 analyzer using eBiosence and Cloud‑Clone Corp reagent kits for the serum concentration of oncogenesis markers MMP‑9 and TGF‑β1.Results. Initial increase of MMP‑9 concentration was detected in all groups of PCC patients compared to the control group (p ≤ 0.05). According to the results of ROC analysis, this indicator has high specificity and sensitivity for prognosis of preoperative stage of renal cell carcinoma. The sensitivity and specificity of MMP‑9 were 87.5 % and 62 %, respectively, and the diagnostically significant level of MMP‑9 was 958 ng/ml. A comprehensive analysis of the content of MMP‑9 and TGF‑β1 oncogenesis markers in serum and tumor cells revealed the correlation of these indicators in various biological objects.Conclusion. Markers of oncogenesis and nephrofibrosis TGF‑β1 and MMP‑9 provide an opportunity for non‑invasive monitoring of tumor progression and probability of metastasis in the clinical setting. Serum MMP‑9 are a reliable predictor of tumor growth. Serum TGF‑β1 concentration isn't a sufficiently reliable marker of tumor progression.
PERUBAHAN KIMIA DAN MIKROBIOLOGI TEMPE BUSUK SELAMA FERMENTASI
Authors: Nuraini Vivi , Puyanda Irvia Resti , Kunciati Widasari Atrilania Sri , Margareta Laurensia Atha 
Published: June 2022

Tempeh is a very popular food because it is delicious and has good nutritional value. Overfermented tempeh is used as a seasoning in dishes such as lodeh and sambal tumpang. Thus, it is necessary to know the length of time tempeh fermentation is safe for consumption. The purpose of this study was to determine the chemical and microbiological quality of over-fermented tempeh and the effect of the packaging used. This study used a 2-factor factorial completely randomized design. The first factor is the storage time of tempeh (1 day, 3 days, 5 days, 7 days, and 9 days), and the second factor is the type of tempeh packaging (plastic, teak leaves, and banana leaves). The results of the water content test showed that the tempeh began to decay in storage for 5 days. Teak leaf packaging has the lowest water content of the others. Tempeh, which has the highest protein content of 0.60 g/L, is tempeh packaged in teak leaves that has been stored for 3 days. Tempeh stored for 9 days has high water content, exceeding the maximum SNI standard (SNI 3144:2015) by about 65%. Soluble protein levels increased and then decreased during the decomposition process. Free fatty acids continued to experience a decrease in storage for 9 days, which indicated that the process of decay had occurred. The highest free fatty acids were found after 3 days of storage in plastic packaging, which reached 6.2 mg NaOH/g, while tempeh packaged with teak on the third day still showed a lower value of 3.83 mg NaOH/g. The total bacteria test showed an increasing trend from the first day to the ninth day of storage. Tempeh was still suitable for consumption up to five days after being stored. After 5 days of storage, tempeh has decreased in quality. Teak leaves have been proven to be able to maintain the quality of tempeh better than plastic packaging or banana leaf packaging.
Keywords: banana leaf, FFA (free fatty acid), teak leaf, tempeh
Computer Assisted Diagnosis of Bipolar Disorder Using Invariant Features
Authors: Jiji Wiselin , A Muthuraj 
Published: June 2022

Abstract
In the study, a supervised learning framework is focussed to identify the bipolar disorder (BD) using structural magnetic resonance imaging is focussed. The work is based on the newly developed 3D SIFT and 3D SURF feature vectors with pattern recognition technique.The overall hypothesis is to deduct BD results from dysfunctional cellular metabolism within specific brain systems (i.e., anterior limbic brain network) as reflected in abnormalities in brain activation patterns and in specific neurochemical measures. The proposed method is used to integrate neuroimaging in exploring the biomarkers of bipolar disorder to reveal the mechanism. In the method, two newly developed feature vectors and kernel PCA are combined or connected to project the feature vectors. Diagnosis process is done by Random Forest. The results reveal that the method has high potential to identify the BD than earlier works, and an average accuracy of 77.77% is reached. This research reveals that neuroimaging studies will help to differentiate bipolar disorder from healthy controls.
Soil Erosion and Sediment Yield Estimation in Ravine Affected Area with Integration of Geospatial Techniques and Revised Universal Soil Loss Equation
Authors: Pani Padmini , Routh Robi , Mohapatra Surya Narayan 
Published: June 2022

Abstract
A considerable amount of plant supportive top soil removal due to water erosion is a major concern for the agricultural dependent countries. The district Morena is one such regions, where top soil is a growing concern for centuries. A huge quantity of soil loss in the region experiences every monsoon season. Quantifying soil loss is a challenging due to its severely dissected topography. The objective of this study is to estimate and map the mean annual soil loss as well as sediment yield for different years in most severely soil erosion affected district of Morena in Madhya Pradesh, India. The Revised Universal Soil Loss Equation and Sediment Delivery Ratio with Integration of Geospatial Techniques have been applied using various open sources data to address the objectives. It has been found that soil erosion has been varied in 1985, 2005 and 2014 respectively. In the year 2005 the soil loss has been reduced compared to 1985, which has been higher again in 2014 (0–66.00 tons/hectors/year in 2005 increased to 0–67.10 tons/hectors/year in 2014), especially when the total wasteland have been reduced substantially, as wastelands are the major contributing area of jungle in the district. The area seems to be going through active erosional process which is subsided by the anthropogenic process in a form of ravine land levelling. The ravine levelled lands are prone to further soil loss in a long run. Therefore, proper management practice needs to be introduced to prevent further soil loss.
Sex under the influence of psychoactive substances among young people in informal settlements in Kampala, Uganda: prevalence, predictors, and implications for sexual and reproductive health programming
Authors: Ssekamatte Tonny , Nalugya Aisha , Mugambe Richard K. , Wagaba Brenda , Nakalembe Doreen , Mutebi Aloysious , Bagonza Richard Asaba , Tigaiza Arnold , Kansiime Winnie K. , Ssempala Richard , Wafula Solomon T. , Isunju John Bosco , Buregyeya Esther 
Published: June 2022

Abstract
Background
Psychoactive substance use has an impact on risky sexual behaviour. Globaly, over 275 million people use psychoactive substances, however evidence on the predictors of sex under the influence of these substatnces is scanty. We investigated the prevalence and predictors of sex under the influence of psychoactive substances among young people aged 18–24 years.
Methods
A cross-sectional study was conducted among 744 sexually active young psychoactive substance users living in informal settlements in Kampala, Uganda. Data were collected through face-to-face interviews using a digitalized structured questionnaire preloaded on Kobocollect. The questionnaire captured data on the socio-demographic characteristics of the respondents, history of psychoactive substance use, and sexual behaviours. Data were analysed using STATA Version 14.0. A modified Poisson regression model was used to determine the factors associated with the outcome variable. Adjusted prevalence ratios at a p-value value ≤ 0.05 with a 95% confidence interval were considered.
Results
About 61.0% (454/744) of the respondents had sex under the influence of psychoactive substances in the last 30 days. The predictors of sex under the influence of psychoactive substances were being female (PR 1.18, 95% CI: 1.04–1.34), being 20–24 years of age (PR: 1.22, 95% CI: 1.04–1.44), being married (PR 1.15, 95% CI: 1.01–1.31) or divorced/separated (PR 1.43, 95% CI: 1.26–1.61), not living with biological parents or guardians (PR 1.22, 95% CI: 0.99–1.50), earning 71 USD and below (PR 0.86, 95% CI: 0.79–1.03) and using alcohol (PR 1.43, 95% CI: 1.25–1.69), marijuana (PR 1.16, 95% CI: 1.02–1.31) and khat (PR 1.25, 95% CI: 1.10–1.42) in the last 30 days.
Conclusion
This study revealed a high prevalence of sex under the influence of psychoactive substances among young people in informal settlements in Kampala, Uganda. The predictors of sex under the influence of psychoactive substances were being female, being 20–24 years of age, being married or divorced/separated, not living with biological parents or guardians, and using alcohol, marijuana and khat in the last 30 days. There is a need for sexual and reproductive health programs to incorporate risk reduction interventions that aim to reduce sex under the influence of psychoactive substances among the said categories in informal settlements.
Direct Comparison Two Fixed-ratio Combination Glucagon-like Peptide Receptor Agonist and Basal Insulin on Glycemic and Non Glycemic Parameters in Type 2 Diabetes
Authors: Risovic Ivona , Dumanovic Mirjana Sumarac , Bojic Mirjana , Djekic Danijel 
Published: June 2022

Abstract
Background.
Two types of fixed-ratio combinations of basal insulin and a glucagon-like protein-1 receptor agonist (GLP-1RA) have been approved for use in type 2 diabetes. One is insulin degludec/liraglutide(iDergLira), and the other is insulin glargine/lixisenatide (iGlarLixi). Direct comparisons between these two combination is not available.
Methods.
The retrospective study included 186 patients with type 2 DM with inadequate glycemic control on metformin and basal insulin (degludec, glargin 100, glargin 300) who were switched fixed-ratio combination GLP-1 RA and basal insulin.Patients were divided into two groups based on the basal insulin before study: group I ( n = 86) treated with degludec were switched to iDegLira and patients group II ( n = 99), 48 treated with glargin were switched to iGlarLixi. The aim of this study was to direct compare the effect between two fixed – ratio combination on glycemic parameters and non glycemic parameters. Follow up was 6 months.
Results
. Mean HbA1c decreased similarly (-1.2% vs.-1.1%). Higher percentage patients in iDegLira group had reached the HbA1c < 7% after 6 months ( 22% vs. 18.2%, p < 0.05). The mean change in FPG was comparable for the two groups, while mean decrease PPG level were lower in iGlarLixi group (2 vs 1.8 mmol/l, p > 0.05). Change in body weight were significant difference in iDegLira group (1.8 kg vs. 0.7 kg, p < 0.001). At the end of the study patients showed decreased in total cholesterol and LDL for 0.2 mmol/L in iDegLira, 0.1 mmol/l in iGlarLixi, triglycerids for 0.3 mmol/l in both groups, increase HDL for 0.1 mm/l in iGlarLixi.
Conclusion
. Our results showed that more patients with iDegLira had HbA1c less than 7% and these combination had better effect on weight loss. There were no difference on FPG and PPG, lipid profile and rate of hypoglycemia.