bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Company Characteristics and Sales Growth on Sustainability Report
Authors: Handayani Riaty 
Published: January 2022

The sustainability of manufacturing companies is still an issue for innovative business activities in meeting the needs of future generations. The problem that becomes the urgency of this research is that return on assets, leverage, and sales growth affects the sustainability report. For this reason, quantitative research with multiple regression analysis is carried out for testing and examining the effect of company characteristics and sales growth on the sustainability report. The data used in this study is secondary data in the form of financial statements of each sample company, namely manufacturing companies that have been audited to be reported to the Indonesia Stock Exchange (IDX) from 2015-2019. Measurements in company characteristics are measured by return on assets (ROA), Leverage, and company growth. The Technology Readiness Level (TKT) is a proof-of-concept of important analytical and experimental functions and/or characteristics. The output of this research design is an international journal.
In this study, the results show that profitability and sales growth have a significant effect on the sustainability report and company size has no significant effect on the sustainability report.
Reliability of patient self‐report of cognition, awareness, and consciousness during seizures
Authors: Zhao Charlie W. , Gebre Rahiwa , Baykara Yigit , Chen William , Vitkovskiy Petr , Li Ningcheng , Johnson Michelle , Chen Eric Y. , Kluger Dan , Blumenfeld Hal 
Published: January 2022

AbstractObjectiveClinicians rely on patient self‐report of impairment during seizures for decisions including driving eligibility. However, the reliability of patient reports on cognitive and behavioral functions during seizures remains unknown.MethodsWe administered a daily questionnaire to epilepsy patients undergoing continuous video‐EEG monitoring, asking about responsiveness, speech, memory, awareness, and consciousness during seizures in the preceding 24 hours. We also administered a questionnaire upon admission about responsiveness, speech, and awareness during seizures. Subjective questionnaire answers were compared with objective behavioral ratings on video review. Criteria for agreement were Cohen’s kappa >0.60 and proportions of positive and negative agreement both >0.75.ResultsWe analyzed 86 epileptic seizures in 39 patients. Memory report on the daily questionnaire met criteria for agreement with video review (κ = 0.674 for early, 0.743 for late recall). Subjective report of awareness also met agreement criteria with video ratings of memory (κ = 0.673 early, 0.774 late). Concordance for speech was relatively good (κ = 0.679) but did not meet agreement criteria, nor did responsiveness or consciousness. On the admission questionnaire, agreement criteria were met for subjective report of awareness versus video ratings of memory (κ = 0.814 early, 0.806 late), but not for other comparisons.InterpretationPatient self‐report of memory or awareness showed the best concordance with objective memory impairment during seizures. Self‐report of impairment in other categories was less reliable. These findings suggest that patient reports about impaired memory during seizures may be most reliable, and otherwise determining functional impairments should be based on objective observations.
Clinical features, investigations, and outcomes of pediatric limbic encephalitis: A multicenter study
Authors: Sabanathan Saraswathy , Abdel‐Mannan Omar , Mankad Kshitij , Siddiqui Ata , Das Krishna , Carr Lucinda , Eltze Christin , Eyre Michael , Gadian Jon , Hemingway Cheryl , Kaliakatsos Marios , Kneen Rachel , Krishnakumar Deepa , Lynch Bryan , Parida Amitav , Rossor Thomas , Taylor Micheal , Wassmer Evangeline , Wright Sukhvir , Lim Ming , Hacohen Yael 
Published: January 2022

AbstractObjectivesTo describe the clinical presentation, investigations, management, and disease course in pediatric autoimmune limbic encephalitis (LE).MethodsIn this retrospective observational study, from the UK Childhood Neuroinflammatory Disease network, we identified children from six tertiary centers with LE <18 years old between 2008 and 2021. Clinical and paraclinical data were retrieved from medical records.ResultsTwenty‐five children fulfilling LE criteria were identified, with median age of 11 years (IQR 8, 14) and median follow‐up of 24 months (IQR 18, 48). All children presented with seizures; 15/25 (60%) were admitted to intensive care. Neuroimaging demonstrated asymmetric mesial temporal changes in 8/25 (32%), and extra‐limbic changes with claustrum involvement in 9/25 (38%). None were positive for LGI1/CASPR2 antibodies (Abs), 2/25 were positive for serum anti‐NMDAR Abs, and 2/15 positive for anti‐Hu Abs; one died from relapsing neuroblastoma. Two children had serum and CSF anti‐GAD antibodies. Initial immune therapy included steroids in 23/25 (92%), intravenous immunoglobulin (IVIg) in 14/25 (56%), and plasma exchange in 7/25 (28%). The commonest second‐line treatment was rituximab in 15/25 (60%). Median duration of hospital admission was 21 days (IQR 11, 30). At last follow‐up, 13/25 (52%) had refractory seizures and 16/25 (64%) had memory impairment. Six children (24%) had modified Rankin Scale (mRS) scores ≥3. There was no significant difference in mRS, or long‐term cognitive and epilepsy outcomes in those who received rituximab versus those who did not.InterpretationA diagnosis of autoimmune LE was associated with significant morbidity and adverse outcomes in this pediatric cohort.
Designer Extracellular Vesicles Modulate Pro‐Neuronal Cell Responses and Improve Intracranial Retention
Authors: Ortega‐Pineda Lilibeth , Sunyecz Alec , Salazar‐Puerta Ana I. , Rincon‐Benavides Maria Angelica , Alzate‐Correa Diego , Anaparthi Amrita Lakshmi , Guilfoyle Elizabeth , Mezache Louisa , Struckman Heather L. , Duarte‐Sanmiguel Silvia , Deng Binbin , McComb David W. , Dodd Daniel J. , Lawrence William R. , Moore Jordan , Zhang Jingjing , Reátegui Eduardo , Veeraraghavan Rengasayee , Nelson M. Tyler , Gallego‐Perez Daniel , Higuita‐Castro Natalia 
Published: January 2022

AbstractGene/oligonucleotide therapies have emerged as a promising strategy for the treatment of different neurological conditions. However, current methodologies for the delivery of neurogenic/neurotrophic cargo to brain and nerve tissue are fraught with caveats, including reliance on viral vectors, potential toxicity, and immune/inflammatory responses. Moreover, delivery to the central nervous system is further compounded by the low permeability of the blood brain barrier. Extracellular vesicles (EVs) have emerged as promising delivery vehicles for neurogenic/neurotrophic therapies, overcoming many of the limitations mentioned above. However, the manufacturing processes used for therapeutic EVs remain poorly understood. Here, we conducted a detailed study of the manufacturing process of neurogenic EVs by characterizing the nature of cargo and surface decoration, as well as the transfer dynamics across donor cells, EVs, and recipient cells. Neurogenic EVs loaded with Ascl1, Brn2, and Myt1l (ABM) are found to show enhanced neuron‐specific tropism, modulate electrophysiological activity in neuronal cultures, and drive pro‐neurogenic conversions/reprogramming. Moreover, murine studies demonstrate that surface decoration with glutamate receptors appears to mediate enhanced EV delivery to the brain. Altogether, the results indicate that ABM‐loaded designer EVs can be a promising platform nanotechnology to drive pro‐neuronal responses, and that surface functionalization with glutamate receptors can facilitate the deployment of EVs to the brain.
Stretchable Mesh Nanoelectronics for 3D Single‐Cell Chronic Electrophysiology from Developing Brain Organoids
Authors: Le Floch Paul , Li Qiang , Lin Zuwan , Zhao Siyuan , Liu Ren , Tasnim Kazi , Jiang Han , Liu Jia 
Published: January 2022

AbstractHuman induced pluripotent stem cell derived brain organoids have shown great potential for studies of human brain development and neurological disorders. However, quantifying the evolution of the electrical properties of brain organoids during development is currently limited by the measurement techniques, which cannot provide long‐term stable 3D bioelectrical interfaces with developing brain organoids. Here, a cyborg brain organoid platform is reported, in which “tissue‐like” stretchable mesh nanoelectronics are designed to match the mechanical properties of brain organoids and to be folded by the organogenetic process of progenitor or stem cells, distributing stretchable electrode arrays across the 3D organoids. The tissue‐wide integrated stretchable electrode arrays show no interruption to brain organoid development, adapt to the volume and morphological changes during brain organoid organogenesis, and provide long‐term stable electrical contacts with neurons within brain organoids during development. The seamless and noninvasive coupling of electrodes to neurons enables long‐term stable, continuous recording and captures the emergence of single‐cell action potentials from early‐stage brain organoid development.
A Review on Mechanochemistry: Approaching Advanced Energy Materials with Greener Force
Authors: Liu Xingang , Li Yijun , Zeng Li , Li Xi , Chen Ning , Bai Shibing , He Hanna , Wang Qi , Zhang Chuhong 
Published: January 2022

AbstractMechanochemistry with solvent‐free and environmentally friendly characteristics is one of the most promising alternatives to traditional liquid‐phase‐based reactions, demonstrating epoch‐making significance in the realization of different types of chemistry. Mechanochemistry utilizes mechanical energy to promote physical and chemical transformations to design complex molecules and nanostructured materials, encourage dispersion and recombination of multiphase components, and accelerate reaction rates and efficiencies via highly reactive surfaces. In particular, mechanochemistry deserves special attention because it is capable of endowing energy materials with unique characteristics and properties. Herein, the latest advances and progress in mechanochemistry for the preparation and modification of energy materials are reviewed. An outline of the basic knowledge, methods, and characteristics of different mechanochemical strategies is presented, distinguishing this review from most mechanochemistry reviews that only focus on ball‐milling. Next, this outline is followed by a detailed and insightful discussion of mechanochemistry‐involved energy conversion and storage applications. The discussion comprehensively covers aspects of energy transformations from mechanical/optical/chemical energy to electrical energy. Finally, next‐generation advanced energy materials are proposed. This review is intended to bring mechanochemistry to the frontline and guide this burgeoning field of interdisciplinary research for developing advanced energy materials with greener mechanical force.
Substrate‐Free Chemical Vapor Deposition of Large‐Scale III–V Nanowires for High‐Performance Transistors and Broad‐Spectrum Photodetectors
Authors: Yin Yanxue , Guo Yanan , Liu Dong , Miao Chengcheng , Liu Fengjing , Zhuang Xinming , Tan Yang , Chen Feng , Yang Zai‐xing 
Published: January 2022

AbstractLarge‐scale growth of high‐quality III–V nanowires (NWs) on an expected substrate is challenging the next‐generation optoelectronic devices. In this work, high‐quality III–V NWs of binary GaSb, GaAs and ternary GaAsxSb1−x, InxGa1−xAs are successfully prepared on the hard substrates of SiO2/Si, amorphous glass and flexible substrates of mica, glass fiber, and carbon cloth by adopting the simple and low‐cost metal‐catalyzed chemical vapor deposition (CVD) method. The homogeneity of morphology, crystallinity, and stoichiometry is checked by scanning electron microscopy, X‐ray diffraction, high‐resolution transmission electron microscopy, and energy dispersive X‐ray spectroscopy, implying the high‐quality phase purity of III–V NWs on various substrates. When configured into NW field‐effect‐transistors, the electrical properties, such as field‐effect mobilities of GaSb NWs grown on various substrates show relatively similar satisfactory values. Meanwhile, the as‐fabricated GaSb NWs photodetector exhibits excellent broad‐spectrum photodetection ability from visible to near‐infrared bands. Furthermore, by adopting a home‐made stepper CVD method, large‐scale GaSb NWs with uniform morphology, crystallinity, stoichiometry, and electrical properties are prepared on glass. All results guide the easy growth of high‐quality functional NWs on any expected substrates for further photoelectronic applications.
Electrochemical Synthesis of Tetrahydroquinolines from Imines and Cyclic Ethers via Oxidation/Aza‐Diels‐Alder Cycloaddition
Authors: Vil' Vera A. , Grishin Sergei S. , Baberkina Elena P. , Alekseenko Anna L. , Glinushkin Alexey P. , Kovalenko Alexey E. , Terent'ev Alexander O. 
Published: January 2022

AbstractElectrochemical synthesis of cyclic ether‐annulated tetrahydroquinolines from imines and cyclic ethers in an undivided cell under constant current conditions was developed. The electrosynthesis proceeds via the enol ether formation from ethers following the aza‐Diels‐Alder [4+2] cycloaddition. The method is applicable to a wide range of imines and results in the desired products in yields of 23 to 75%. In situ preparation of imines from the corresponding anilines and aldehydes led to mostly the same yields of tetrahydroquinolines. No cycloaddition products were formed using the chemical oxidants. Synthesized cyclic ether‐annulated tetrahydroquinolines exhibit high antifungal activity, which is superior to the commercial fungicide Triadimefon.magnified image
Energy Saving and Energy Generation Smart Window with Active Control and Antifreezing Functions
Authors: Niu Yingchun , Zhou Yang , Du Daxue , Ouyang Xiangcheng , Yang Ziji , Lan Wenjie , Fan Fan , Zhao Sisi , Liu Yinping , Chen Siyuan , Li Jiapeng , Xu Quan 
Published: January 2022

AbstractWindows are the least energy efficient part of the buildings, as building accounts for 40% of global energy consumption. Traditional smart windows can only regulate solar transmission, while all the solar energy on the window is wasted. Here, for the first time, the authors demonstrate an energy saving and energy generation integrated smart window (ESEG smart window) in a simple way by combining louver structure solar cell, thermotropic hydrogel, and indium tin oxides (ITO) glass. The ESEG smart window can achieve excellent optical properties with ≈90% luminous transmission and ≈54% solar modulation, which endows excellent energy saving performance. The outstanding photoelectric conversion efficiency (18.24%) of silicon solar cells with louver structure gives the smart window excellent energy generation ability, which is more than 100% higher than previously reported energy generation smart window. In addition, the solar cell can provide electricity to for ITO glass to turn the transmittance of hydrogel actively, as well as the effect of antifreezing. This work offers an insight into the design and preparation together with a disruptive strategy of easy fabrication, good uniformity, and scalability, which opens a new avenue to realize energy storage, energy saving, active control, and antifreezing integration in one device.
Influence of surfactant‐humectant adjuvants on physical properties, droplet size, and efficacy of glufosinate formulations
Authors: Polli Estefania G. , Alves Guilherme S. , Gizotti de Moraes Jesaelen , Kruger Greg Robert 
Published: January 2022

AbstractGlufosinate efficacy is inconsistent among weed species and under environmental conditions that favor rapid droplet drying. Surfactant‐humectant adjuvants could maximize glufosinate efficacy by increasing wetting and penetration into the leaf surface while decreasing evaporation rate (ER). However, there is a lack of information in the literature about the interaction of surfactant‐humectants adjuvants with glufosinate. The objective of this study was to investigate the influence of surfactant‐humectant adjuvants on the physical properties, droplet size, and efficacy of two glufosinate formulations. Laboratory, greenhouse, and field studies were conducted at the Pesticide Application Technology Laboratory of the University of Nebraska‐Lincoln. Treatment design was a 2 × 5 factorial with two glufosinate formulations combined with five adjuvant treatments plus an untreated control. Density and viscosity of glufosinate solutions mostly increased with the addition of adjuvants. However, the influence of the adjuvants on dynamic surface tension (dST), static contact angle (sCA), and evaporation rate (ER) varied by glufosinate formulation, adjuvant, and relative humidity (RH). Under greenhouse conditions, an improvement in efficacy by adding adjuvants was mainly observed for Interline solutions. The addition of adjuvants to Interline solutions increased biomass reduction up to 19 and 35% for common lambsquarters (Chenopodium album L.) and kochia [Bassia scoparia (L.) A. J. Scott], respectively. Also, some of the adjuvants presented null or antagonistic influence on herbicide efficacy. No increase in control, biomass reduction, and mortality of horseweed (Erigeron canadensis L.) and Palmer amaranth (Amaranthus palmeri S. Watson) was observed with the use of adjuvants under field conditions. Herbicide‐adjuvant‐plant‐environment interaction is complex. Thus, the use of surfactant‐humectant adjuvants may not increase herbicide efficacy.
Post‐harvest crop residue contribution to soil N availability or unavailability in North Dakota
Authors: Alghamdi Rashad S. , Cihacek Larry , Daigh Aaron Lee M. , Rahman Shafiqur 
Published: January 2022

AbstractNorth Dakota producers have adopted conservation tillage practices to conserve soil moisture and reduce wind and water erosion. As a result, an accumulation of crop residue has been observed but current recommendations encourage a fertilizer N credit in fields under no‐till for more than 6 yr. Producers are concerned that post‐harvest crop residues are not contributing to N needs of subsequent crops during the growing season. This study was established to assess N mineralization from common crop residue in conventional tillage systems using long‐term incubation studies in order to establish a baseline for future studies on no‐till systems. Three commonly cultivated North Dakota soil series were selected for study with seven residue treatments (varying C/N ratios) including corn (Zea mays L.), soybean [Glycine max (L.) Merr.], flax (Linum usitatissimum L.), forage radish (Raphanus sativus L.), winter pea (Pisum sativum L.), spring and winter wheat (Triticum aestivum L.), and a soil‐only control. Biweekly leachings were collected for nine incubation periods and analyzed for nitrate‐nitrogen (NO3–N). Soils with higher organic matter (OM) resulted in increased soil N mineralization (Fargo [1.63 mg kg–1 N] > Forman [0.65 mg kg–1 N] > Heimdal–Emrick [0.38 mg kg–1 N]). Radish and pea residues (narrow C/N ratios) were the only treatments showing N mineralization potential compared with the soil only controls. However, post‐harvest residues with wide C/N ratios (>25:1) promote N immobilization when compared with mineralization by the soil alone. These findings raise the question of whether the N credits for >6 yr of no‐till management are appropriate in the northern Great Plains.
Evaluation of temporal variability on tissue nutrient concentrations of canola
Authors: Reed Vaughn , Sutradhar Apurba K. , Arnall D. Brian , Lofton Josh 
Published: January 2022

AbstractThe use of plant tissue analysis as a tool for diagnosing nutrient deficiency has steadily gained interest by producers and crop advisors in Oklahoma. A study was conducted during the 2012–2013 and 2015–2016 growing seasons at two locations near Stillwater and Perry, OK, to evaluate the variability of canola (Brassica napus L.) nutrient concentrations across various growth stages (STAGE), among several days within each growth stage (DAY), across several times during the day (TIME). Canola tissue samples were collected in the morning, noon, and evening for three consecutive days at rosette, postdormancy break, and prebolting stages. Samples were analyzed for macronutrients (N, P, K) and secondary (S, Ca, Mg) nutrient concentrations. Tissue nutrient concentrations were found to be extremely variable, as affected by main effects and interactions of sampling TIME, DAY, and STAGE. Nutrient concentration generally increased over time, for most nutrients. The analysis did not indicate any definitive pattern of tissue nutrient accumulation based on the fixed effects TIME and DAY. Although, the exact reasons for the different responses are not known, they may be related to soil physical and chemical property differences and variation in weather factors. While this work does not provide insight in the relationship between nutrient concentrations and crop yield, this does bring to light complications with using tissue analysis for management decisions. Further work must be done to investigate the relationships of tissue concentration and yield, and the viability of tissue sampling for nutrient management.
Transformer‐Induced Metamorphosis of Polymeric Nanoparticle Shape at Room Temperature
Authors: Parkatzidis Kostas , Truong Nghia P. , Rolland Manon , Lutz‐Bueno Viviane , Pilkington Emily H. , Mezzenga Raffaele , Anastasaki Athina 
Published: January 2022

AbstractControlled polymerizations have enabled the production of nanostructured materials with different shapes, each exhibiting distinct properties. Despite the importance of shape, current morphological transformation strategies are limited in polymer scope, alter the chemical structure, require high temperatures, and are fairly tedious. Herein we present a rapid and versatile morphological transformation strategy that operates at room temperature and does not impair the chemical structure of the constituent polymers. By simply adding a molecular transformer to an aqueous dispersion of polymeric nanoparticles, a rapid evolution to the next higher‐order morphology was observed, yielding a range of morphologies from a single starting material. Significantly, this approach can be applied to nanoparticles produced by disparate block copolymers obtained by various synthetic techniques including emulsion polymerization, polymerization‐induced self‐assembly and traditional solution self‐assembly.
Synthese von C‐Oligosacchariden via vielseitiger C(sp3)‐H‐Glykosylierung von Glykosiden
Authors: Wu Jun , Kopp Adelina , Ackermann Lutz 
Published: January 2022

AbstractC‐Oligosaccharide sind pharmakologisch relevant, weil sie hydrolysebeständiger sind als O‐Oligosaccharide. Trotz unbestreitbarer Fortschritte sind C‐Oligosaccharide nach wie vor wenig erforscht, meist aufgrund des Mangels an effizienten und selektiven Strategien für den Aufbau von C‐C‐Bindungen. Im Gegensatz dazu veröffentlichen wir hier eine vielseitige und robuste Strategie für die Synthese strukturell komplexer C‐Oligosaccharide via einer katalytischen C(sp3)‐H‐Aktivierung. Auf diese Weise ist eine Fülle von komplexen interglykosidischen (2→1)‐ und (1→1)‐C‐Oligosaccharide mittels einer Palladium‐katalysierter C(sp3)‐H‐Glykosid‐Glykosylierung einfacher zugänglich. Die Isolierung von Schlüsselintermediaten des Palladacyclus und experimentell isotopisch markierten Verbindungen ergaben eine trans‐ Stereoselektivität für die C(sp3)‐H‐Glykosylierung. Der glykosidische C(sp3)‐H‐Aktivierungsmechanismus wurde ebenfalls für die Diversifizierung von Furanosen, Pyranosen und Disacchariden angewandt.