bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nuclear export inhibition jumbles epithelial-mesenchymal states and gives rise to migratory disorder in healthy epithelia
Authors: Krull Carly M. , Li Haiyi , Pathak Amit 
Published: June 2022

AbstractEpithelial-mesenchymal (E-M) phenotypes govern collective cellular behaviors to facilitate diverse tissue functions, including embryogenesis, wound healing, and cancer invasion. Cellular E-M state is regulated by dynamic nucleocytoplasmic transport of corresponding E-M factors; yet, it remains unknown how concurrently trapping these factors affects epithelia at the macroscale. To explore this question, we performed nuclear export inhibition (NEI) via Leptomycin B treatment, which biases nuclear localization of CRM1- associated E-M factors. We examined changes in collective cell migration across a range of substrate stiffnesses. Our results show that NEI fosters an atypical E-M state wherein cells concurrently strengthen intercellular adhesions and develop mechanoactive characteristics. Following NEI, soft substrates elevate collective migration for up to 24 h, while stiffer substrates reduce migration at all timepoints. We demonstrate that excluding Yes-associated protein 1 from NEI shifts affected cells toward an epithelial phenotype. Meanwhile, removing α-catenin maintains NEI’s intercellular adhesion strengthening and mechanoactivation capabilities, but prevents mechanoactive characteristics from reaching collective behavior. Overall, our results show that NEI disrupts epithelial migration through competition between intercellular adhesions, mechanoactivation, and cell-cell coordination. Ultimately, these findings of mechanoactive NEI outcomes for healthy cells could warrant additional investigation in the context of NEI-centered cancer therapies.
Resolving the fate of trace metals during microbial remineralization of phytoplankton biomass in precursor banded iron formation sediments
Authors: Rico Kathryn , Schad Manuel , Picard Aude , Kappler Andreas , Konhauser Kurt , Mahmoudi Nagissa 
Published: June 2022

AbstractBanded Iron Formations (BIFs) have long been considered a sedimentary record of seawater trace metal composition during the Precambrian. However, recent work has suggested that the trace metal composition of BIFs was derived from phytoplankton biomass, not seawater. In this model, phytoplankton biomass settles from the photic zone to the seafloor sediments, where it is then oxidized by heterotrophic microbes, such as dissimilatory Fe(III) reducing (DIR) bacteria, for energy generation. Remineralization of this biomass released the trace metals associated with organic molecules from phytoplankton (i.e., in metalloproteins), allowing these metals to be captured by Fe (oxyhydr)oxides and preserved in BIFs. While there is compelling evidence that the phytoplankton biomass served as a trace metal shuttle to precursor BIF sediments, it is unclear whether the degradation of biomass by DIR bacteria would liberate the biogenic trace metals as the model proposes. This work tests this hypothesis by using anoxic incubations of a model DIR bacterium (Shewanella oneidensis MR-1) with phytoplankton biomass as energy and carbon sources and ferrihydrite, a poorly crystalline Fe(III) oxyhydroxide (Fe(OH)3), as electron acceptor. Our results show that while S. oneidensis MR-1 can consume some of the carbon substrates found in phytoplankton biomass, there is no evidence that S. oneidensis MR-1 degraded metalloproteins which would have liberated trace metals. In the context of the Precambrian, these data imply that other heterotrophic bacteria, such as fermenters, may have had a larger role in the liberation of trace metals from dead biomass during early BIF development.HighlightsPhytoplankton are the proposed source of trace metals to banded iron formationsIron reducers are hypothesized to release metals from phytoplankton biomassExperiments show that iron reducers do not liberate metals when degrading biomassOther microbial heterotrophs must have liberated the biogenic trace metals
Inositol phosphorlyceramide synthase null Leishmania major are viable and virulent in animal infections where salvage of host sphingomyelin predominates
Authors: Kuhlmann F. Matthew , Key Phillip N. , Hickerson Suzanne M. , Turk John , Hsu Fong-Fu , Beverley Stephen M. 
Published: June 2022

AbstractMany pathogens synthesize inositolphosphorylceramide (IPC) as the major sphingolipid (SL), differing from the mammalian host where sphingomyelin (SM) or more complex SLs predominate, and the divergence between IPCS and mammalian sphingolipid synthases has prompted interest as a potential drug target. However, in the trypanosomatid protozoan Leishmania, cultured insect stage promastigotes lacking de novo sphingolipid synthesis (Δspt2-) and sphingolipids entirely survive and remain virulent, as infective amastigotes salvage host sphingolipids and continue to produce IPC. To further understand the role of IPC, we generated null IPCS mutants in L. major (Δipcs-). Unexpectedly and unlike fungi where IPCS is essential, Δipcs- was remarkably normal in culture and highly virulent in mouse infections. Both IPCS activity and IPC were absent in Δipcs- promastigotes and amastigotes, arguing against an alternative route of IPC synthesis. Notably, salvaged mammalian sphingomyelin (SM) was highly abundant in purified amastigotes from both WT and Δipcs-, and salvaged SLs could be further metabolized into IPC. SM was about 7-fold more abundant than IPC in WT amastigotes, establishing that SM is the dominant amastigote SL, thereby rendering IPC partially redundant. These data suggest that SM salvage likely plays key roles in the survival and virulence of both WT and Δipcs- parasites in the infected host, confirmation of which will require the development of methods or mutants deficient in host SL/SM uptake in the future. Our findings call into question the suitability of IPCS as a target for chemotherapy, instead suggesting that approaches targeting SM/SL uptake or catabolism may warrant further emphasis.
How substitute scarcity appeals effect on experiential gift’s purchase intention?
Authors: Chen Tser-Yieth , Yeh Tsai Lien , Lin Yen Ling 
Published: June 2022

Purpose
The purpose of this study is to explore the substitute scarcity appeals (unit scarcity or option scarcity) effect on experiential gift’s purchase intention, based on difference in gift attribute (hedonic or utilitarian gift) and difference in the types of givers (close or distant giver), which is a new consideration.

Design/methodology/approach
This study was conducted with two experiments and examined four hypotheses in total. These hypotheses were examined using a 2 × 2 between-subjects designs, and a two-factorial covariance analysis was conducted.

Findings
Empirical results show that unit scarcity produces greater purchase intention than the option scarcity of close givers. For hedonic gifts, unit scarcity produced greater purchase intention than the option scarcity.

Originality/value
The originality of this study is to explore the substitute scarcity appeals effect on experiential gift’s purchase intention based on different types of givers and different types of gifts. The result serves as the gift marketing strategy of online platform operators and the future reference for marketers to create more value and purchase intention.
Using existing metadata standards and tools for a digital language archive: a balancing act
Authors: Burke Mary , Tarver Hannah , Phillips Mark Edward , Zavalina Oksana 
Published: June 2022

PurposeBuilding a digital language archive requires a number of steps to ensure collecting, describing, preserving and providing access to language data in effective and efficient ways. The purpose of this paper is to describe how the Computational Resource for South Asian Languages (CoRSAL) group has partnered with the University of North Texas (UNT) Digital Library to build a series of interconnected digital collections that leverage existing UNT technical and metadata infrastructure to provide access to data from and for various language communities.Design/methodology/approachThis paper introduces the reader to the background of this project and discusses some of the areas important for representing language materials where both University of North Texas Libraries (UNTL) metadata and CoRSAL metadata practices were adapted to better fit the needs of intended audiences.FindingsWe discuss a workflow for standardized language representation (the Language field), defining roles for persons related to the item (Creator and Contributor fields) and including subject representation for language materials (Subjects and Keywords fields).Practical implicationsAlthough further work is needed to improve language data representation in the CoRSAL digital language archive, the model adopted by the team and lessons learned could benefit others in the language archiving community.Originality/valueThis paper is a significantly extended version of the presentation made at the 1st International Workshop on Digital Language Archives in 2021.
Feasibility practices of types of property developers
Authors: Moorhead Matthew , Armitage Lynne , Skitmore Martin 
Published: June 2022

PurposeThe purpose of this study is to analyse the current relationships between developer characteristics in terms of dominant property type (residential, commercial, retail, industrial, tourism, “other”), ownership (publicly listed, publicly unlisted, private, government), organisational structure (speculative-trader, investor developers, development managers) and size (small, medium, large) in the frequency of use and required minimum value of hurdle rate metrics.Design/methodology/approachA questionnaire survey of 225 Australian and New Zealand trader developers, development managers, investors, valuers, fund managers and government/charities/other relating to the feasibility practices of different types of Australia/New Zealand property development companies.Findings(1) Residential dominant developers are more likely to use margin on development cost (MDC) required to have a higher minimum internal rate of return (IRR) percentage; (2) investor developers are more likely to use the payback period as a hurdle rate, and specific hurdle rates as a part of a go/no-go decision; (3) trader developers adopt a higher percentage of IRR and deviate further from accepted financial theory in hurdle rate selection; and (4) national property development organisations in multiple geographic regions use qualitative frameworks more as a decision-making process and use MDC less as a hurdle rate.Practical implicationsThe study is limited to a sample of property practitioners working in Australia/New Zealand at the time of data collection in 2016 and, further empirical research is needed spatially and temporally to determine the extent of the findings. Further research is also needed with small- to medium-sized development organisations' on the extent to which they should use different metrics in project selection and for an improved understanding of the technical and attitudinal difficulties facing their current adoption.Originality/valueFirst study to examine the feasibility practices of different types of Australia/New Zealand property developers.
An innovative reliability-based design optimization method by combination of dual-stage adaptive kriging and genetic algorithm
Authors: Feng Kaixuan , Lu Zhenzhou 
Published: June 2022

PurposeThis study aims to propose an efficient method for solving reliability-based design optimization (RBDO) problems.Design/methodology/approachIn the proposed algorithm, genetic algorithm (GA) is employed to search the global optimal solution of design parameters satisfying the reliability and deterministic constraints. The Kriging model based on U learning function is used as a classification tool to accurately and efficiently judge whether an individual solution in GA belongs to feasible region.FindingsCompared with existing methods, the proposed method has two major advantages. The first one is that the GA is employed to construct the optimization framework, which is helpful to search the global optimum solutions of the RBDO problems. The other one is that the use of Kriging model is helpful to improve the computational efficiency in solving the RBDO problems.Originality/valueSince the boundaries are concerned in two Kriging models, the size of the training set for constructing the convergent Kriging model is small, and the corresponding efficiency is high.
What has been studied in cultural intelligence? Intellectual structure and current research
Authors: Paraíso De Campos Serra Bernardo , Tomei Patricia Amelia , Serra Fernando , Guerrazzi Luiz Antonio de Camargo 
Published: June 2022

Purpose
The purpose of this paper is to examine existing research in Cultural Intelligence (CI), in an attempt to understand the intellectual influences on current research and research trends.

Design/methodology/approach
The authors used a bibliometric study of cocitation and bibliographic coupling, supported by factor and network analysis. From a sample of 219 articles, the authors examined selected articles (60 for bibliographic coupling) and the references (32 for citation and cocitation).

Findings
The results indicate that Earley and Ang (2003) is the basis for the current research. The intellectual structure of CI was concerned with three themes: the Concept of CI; CI and the Cultural Context; and Operationalization of the CI Concept. This initial research has influenced current research in the Operationalization of the Concept of CI when investigating the effect of CI on cultural diversity and individual skills and abilities. Another front recognizes the relationship between CI and the cultural context, being oriented toward understanding the performance and leadership of individuals.

Originality/value
The authors identified a new research front related to the effect of CI on cultural diversity. It indicates promising new fronts considering culture in a multifaceted and multilevel perspective, and also the possibility of evaluating the construct's cognitive components in the original perspective of Earley and Ang (2003) with neuroscientific methods. From the analysis, the authors suggest that future research presents methodological challenges and the connection of the CI construct and the level of analysis, and the Latin American context, which are explored at the end of this paper.
Social interaction and geographic diffusion of iron‐biofortified beans in Rwanda
Authors: Funes Jose , Sun Laixiang , Sedano Fernando , Baiocchi Giovanni , Benson Todd 
Published: June 2022

AbstractThis study analyzes smallholder farmers’ decisions to adopt beans with higher levels of dietary iron developed through a conventional breeding technique called biofortification. We approach this study by applying spatial econometric techniques to estimate neighborhood influence and to determine the factors driving the adoption of iron‐biofortified beans (IBB). We employ a cross‐sectional, nationally representative survey of bean producing households from 2015 bean growing season B in Rwanda, and present results for growers of both bush and climbing varieties of beans. The results show geographic diffusion of iron bean planting material occurs among neighboring farmers that exhibit interdependent decision‐making patterns, as well as similar characteristics relative to the group. Some policy implications can be drawn from the results. First, a differentiated geographical targeting strategy for bush and climbing bean varieties as a function of farmer and farm characteristics should increase iron bean adoption rates. Second, strengthening partnerships with delivery agents and extensionists should stimulate the adoption of IBB varieties. And finally, technology‐promotion programs that consider progressive farmers and strengthen social interactions and group activities among peer networks should increase the spread of information and diffusion of IBB.
Pro‐work reforms to the settlement support system and the economic adjustment of recipients: Evidence from South Korea
Authors: Han Sam 
Published: June 2022

AbstractThis study examines the effects of the pro‐work reforms to South Korea's North Korean Defectors Settlement Support System (NKDSSS) on the economic adjustment of North Korean Defectors (NKDs) in the country. It analyzes data from the 2010 National Survey of Domestic Violence: NKDs, using a regression discontinuity design. The study finds that the reforms did not affect changes in the economic adjustment of NKDs, measured by employment, household income level, a rate of cash transfer as the main source of income, and welfare receipt. The findings of this study suggest that there are no significant differences in the economic adjustment outcomes of Unconditional Cash Transfers and Conditional Cash Transfers. It also implies that for the pro‐work reforms to be effective to meet the changing needs, there should be rigorous policy evaluations for its reforms to improve the NKDSSS.
Dehydroepiandrosterone alleviates hypoxia‐induced learning and memory dysfunction by maintaining synaptic homeostasis
Authors: Guan Ruili , Yang Changhao , Zhang Jianbin , Wang Jianyu , Chen Rui , Su Peng 
Published: June 2022

AbstractAimsHypoxia causes plenty of pathologies in the central nervous system (CNS) including impairment of cognitive and memory function. Dehydroepiandrosterone (DHEA) has been proved to have therapeutic effects on CNS injuries by maintaining the homeostasis of synapses, yet its effect on hypoxia‐induced CNS damage remains unknown.MethodsIn vivo and in vitro models were established. Concentrations of glutamate and γ GABA were tested by ELISA. Levels of synapse‐associated proteins were measured by western blotting. Density of dendritic protrusions of hippocampal neurons was assessed by Golgi staining. Immunofluorescence was adopted to observe the morphology of primary neurons. The novel object recognition test (NORT) and shuttle box test were used to evaluate cognition.ResultsDehydroepiandrosterone reversed abnormal elevation of glutamate levels, shortenings of neuronal processes, decreases in the density of dendritic protrusions, downregulation of synaptosome‐associated protein (SNAP25), and impaired cognition caused by hypoxia. Hypoxia also resulted in notably downregulation of syntaxin 1A (Stx‐1A). Overexpression of Stx‐1A dramatically attenuated hypoxia‐induced elevation of glutamate. Treatment with DHEA reversed the Stx‐1A downregulation caused by hypoxic exposure.ConclusionDehydroepiandrosterone may exert a protective effect on hypoxia‐induced memory impairment by maintaining synaptic homeostasis. These findings offer a novel understanding of the therapeutic effect of DHEA on hypoxia‐induced cognitive dysfunction.
An intelligent optimization algorithm with a deep learning‐enabled block‐based motion estimation model
Authors: Mishra Awanish Kumar , Kohli Narendra 
Published: June 2022

AbstractThe motion estimation process has gained significant attention in several video applications such as video compression, global motion estimation, and so on. The deep learning (DL) models that perform effectively in computer vision tasks can be employed for motion estimation. Yet, they have high computational complexity and model parameters since motion estimation in the pixel domain is not effective in practical applications. Instead, a block‐based motion estimation process has been developed where the blocks of sequential images are compared. To that end, this paper presents the Anas platyrhynchos optimizer with deep learning‐enabled block‐based motion estimation (APODL‐BBME) model. The proposed model estimates motion using block‐based concepts and DL approaches. To accomplish this, the training and testing frames are separated into non‐overlapping block categories, and the blocks are filtered via the bilateral filtering (BF) approach. In addition, a histogram of gradients (HOG) and densely connected network (DenseNet) model are employed to extract features, which are then fed into the bidirectional long short‐term memory (BiLSTM) model to classify the input features. Finally, the APO algorithm is applied to optimally tune the hyperparameters of the BiLSTM model, which helps to improve the overall motion estimation efficacy, showing the novelty of the work. To demonstrate the enhanced performance of the APODL‐BBME model, a comprehensive analysis is carried out, and when we compare the results, the APODL‐BBME model outperforms recent motion estimation approaches.
Long‐term trajectories of intergenerational coresidence: Evidence of living arrangements patterns in Chile
Authors: Cabib Ignacio , Araos Consuelo , Palma Julieta , Yopo Díaz Martina 
Published: June 2022

AbstractObjectiveThis study examines long‐term trajectories of intergenerational coresidence (IC) among a cohort of individuals aged 65 and 75 in Chile, focusing on their diversity, prevalence, internal dynamism, and sociodemographic characteristics.BackgroundIC is comparatively high in Latin America and is related to both family norms and social vulnerabilities. However, empirical evidence on this topic comes mostly from cross‐sectional studies using aggregated population data, which neglect the inherently dynamic nature of coresidential arrangements across the life course.MethodWe use representative life‐history data in Santiago, Chile (N= 802), sequence analysis to reconstruct long‐term trajectories, and bivariate analysis to examine their associations with sociodemographic factors.ResultsOur findings show that, first, IC in Chile may be more prevalent and diverse than suggested in previous cross‐sectional studies. Second, our findings indicate patterns of long‐term IC and stable conjugal cohabitation are compatible. Third, the results shed new light on the association of IC with particular sociodemographic groups.ConclusionThis study analyzed patterns of living arrangements among family members based both on intergenerational and conjugal cohabitation and their dynamic character throughout the life course. Our results challenge interpretations of contemporary living arrangements among family members at an international level.ImplicationsThis study shows that IC in Chile has been largely underrepresented, both in magnitude and heterogeneity. This finding informs public policies about the reality of family configurations that require specific care, housing, and financial support.
Effect of wind speed and light intensity on reflex impairment of angled Smallmouth Bass (Micropterus dolomieu)
Authors: Forgues Nick , LaRochelle Luc , Burton Declan , Cooke Steven J. 
Published: June 2022

AbstractWe quantified effects of wind speed and sunlight on Smallmouth Bass (Micropterus dolomieu), a popular gamefish in North America, after catch‐and‐release (C&R) (n = 90) during August for various periods (0, 10, 30 and 90 s) in direct sunlight or shaded from direct sunlight. We evaluated change in skin temperature and reflex action mortality predictor (RAMP) scores. Changes in skin temperature were larger with increasing wind speeds and air exposure duration. Light intensity had no effect on skin temperature or RAMP. Generally, skin temperature decreased (i.e. colder) when wind speed exceeded ~5 km/h and increased (i.e. warmer) when wind speed was below ~5 km/h. Significantly, lower RAMP scores were associated with longer air exposure. Generally, Smallmouth Bass exposed to air for longer than 10 s were significantly more impaired prior to release. We recommend anglers reduce the time that large fish are exposed to air to reduce immediate reflex impairment.