bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Significance of Modified Advanced Lung Cancer Inflammation Index in Patients With Renal Cell Carcinoma Undergoing Laparoscopic Nephrectomy: A Multi-Institutional, Propensity Score Matching Cohort Study
Authors: Mao Weipu , Wang Keyi , Wu Yuan , Ni Jinliang , Zhang Houliang , Wang Yidi , Wu Zonglin , Liu Ruiji , Geng Jiang , Chen Shuqiu , Chen Ming 
Published: January 2022

BackgroundWe conducted a multi-institutional clinical study to assess the prognostic value of the advanced lung cancer inflammatory index (ALI) and modified ALI (mALI) in patients with renal cell carcinoma (RCC).MethodsWe collected 440 patients who underwent laparoscopic nephrectomy at three centers from 2014 to 2019. ALI was defined as body mass index (BMI) × serum albumin (ALB)/neutrophil-to-lymphocyte ratio (NLR) and mALI as L3 muscle index × ALB/NLR. Kaplan-Meier curves, receiver operating characteristic (ROC) curves and Cox survival analysis were used to assess the effect of ALI and mALI on overall survival (OS). In addition, we performed 1:1 propensity score matching (PSM) for the high mALI and low mALI groups to further explore the impact of mALI on survival in RCC patients.ResultsThe optimal cut-off values for ALI and mALI were 40.6 and 83.0, respectively. Based on the cut-off values, we divided the patients into high ALI and low ALI groups, high mALI and low mALI groups. ALI and mALI were significantly associated with the AJCC stage, Fuhrman grade, T stage, and M stage. Low ALI (p = 0.002) or low mALI (p &lt; 0.001) was associated with poorer prognosis. ROC curves showed that mALI was a better predictor of OS than ALI. Multivariate Cox regression analysis showed that low mALI (aHR = 2.22; 95% CI 1.19–4.13, p = 0.012) was an independent risk factor for OS in RCC patients who underwent nephrectomy, while ALI (aHR = 1.40; 95% CI 0.73–2.66, p = 0.309) was not significantly associated. Furthermore, after PSM analysis, we found that mALI remained an independent risk factor for OS (aHR = 2.88; 95% CI 1.33–6.26, p = 0.007) in patients with RCC.ConclusionsFor RCC patients undergoing laparoscopic nephrectomy, low ALI and low mALI were associated with poor prognosis, and preoperative mALI can be used as a potential independent prognostic indicator for RCC patients.
PAQR5 Expression Is Suppressed by TGFβ1 and Associated With a Poor Survival Outcome in Renal Clear Cell Carcinoma
Authors: Tao Chang , Liu Wang , Yan Xiang , Yang Min , Yao Si , Shu Qiang , Li Benyi , Zhu Runzhi 
Published: January 2022

BackgroundRenal cell carcinoma (RCC) was sex-hormone responsive, and clinical trials using progesterone significantly reduced the incidence of distal metastasis after radical nephrectomy. Recently membrane-bound progesterone receptors (mPRs) were discovered to mediate the non-genomic effect of progesterone. Aberrant expressions of these mPRs were reported in human breast, ovarian, urinary bladder, brain, uterine, and prostate cancers. However, their expression profiles in RCC are yet to be assessed.MethodsMultiple datasets from RNA sequencing (RNA-seq), cDNA microarray, and proteomic analysis were used to compare gene expression between cancerous and normal kidney tissues. Immunohistochemistry was conducted to examine protein expression in kidney tissues. Promoter methylation levels were assessed for correlation analysis with gene expression.ResultsOf the seven membrane-bound progesterone receptor genes, the progestin and adipoQ receptor-5 (PAQR5) gene is predominantly expressed in normal kidney tissue but was significantly downregulated in RCC tissues. PAQR5 downregulation correlated with tumor stage, cancer grade, lymph node invasion, and distal metastasis only in clear cell RCC (ccRCC) tissues. PAQR5 downregulation was associated with an increased promoter DNA methylation and a poor survival outcome in ccRCC patients. In addition, PAQR5 expression inversely correlated with transforming growth factor beta-1 (TGFB1) expression, and TGFβ1 treatment significantly reduced PAQR5 gene expression.ConclusionPAQR5 is a novel prognostic biomarker in ccRCC and is negatively regulated by the TGFβ1 pathway.
Pengaruh Kompetensi dan Motivasi Karyawan Terhadap Kinerja Pelayanan Penerbitan Sertifikat Kapal Di Kantor KSOP Khusus Batam
Authors: Malau April Gunawan , Togatorop Agus Leonard , Sabpatari Fardhani 
Published: January 2022

Dalam mendukung kinerja pelayanan penerbitan sertifikat kapal di Kantor KSOP Khusus Batam, masih terjadi beberapa masalah pada perusahaan terkait dengan kompetensi dan motivasi karyawan.Masalah tersebut yaitu kurangnya kompetensi tiap karyawan dalam menyelesaikan dan melakukan pekerjaannya, minimnyya motivasi yang terdapat dalam pribadi tiap karyawan dan terjadinya penurunan kualitas kerja.Berdasarkan permasalahan tersebut, penulis melakukan analisis untuk mengetahui apakah ada pengaruh kompetensi dan motivasi karyawan terhadap kinerja pelayanan penerbitan sertifikat kapal di Kantor KSOP Khusus Batam.

Jenis penelitian yang digunakan adalah metode kuantitatif. Pengumpulan data dilakukan dengan kuesioner disebarkan langsung ke 30 responden yaitu pada seluruh karyawan KSOP Khusus Batam dengan jumlah pernyataan sebanyak 26 butir. Dalam mencari hasil perhitungan penulis menggunakan program SPSS 25 dan melakukan beberapa analisis data, yaitu: uji validitas dan realibilitas, analisis koefisien korelasi, analisis koefisien determinasi, uji t hitung dan f hitung dan analisis regresi dengan variable intervening. Penarikan kesimpulan dalam penelitian ini dilakukan dengan membandingkan data yang diperoleh dari jawaban responden yang ada.

Berdasarkan perolehan data kuesioner dan pengolahan data. Diperolah hasil yang menunjukkan bahwa kompetensi dan motivasi secara bersama-sama terbukti positif dan signifikan terhadap kinerja pelayanan penerbitan sertifikat kapal dengan nilai F hitung > F tabel atau 46,521 > 2,36. Penulis memaparkan beberapa solusi untuk meningkatkan kinerja pelayanan penerbitan sertifikat kapal, yaitu: meningkatkan kompetensi karyawan, meningkatkan motivasi karyawan dan memaksimalkan kinerja perusahaan.
A Tertiary Review on Blockchain and Sustainability with Focus on Sustainable Development Goals
Authors: Jiang Shanshan , Jakobsen Kine , Bueie Jonas , Li Jingyue , Haro Peter Halland 
Published: January 2022

<p> Blockchain as a disruptive technology and a driver for social change has exhibited great potential to promote sustainable practices and help organizations and governments achieve the United Nations’ Sustainable Development Goals (SDGs). Literature reviews on blockchain and sustainability exist, but they often focus only on topics related to one or a few SDGs. There is a need to consolidate existing results in terms of SDGs and provide a comprehensive overview of the impacts that blockchain technology may have on each SDG. This paper intends to bridge this gap, presenting a tertiary review based on 34 existing literature reviews, to investigate the relationship between blockchain and sustainability in light of SDGs. The method used is a consensus-based expert elicitation with thematic analysis. The findings include a novel and comprehensive mapping of impact-based interlinkage of blockchain and SDGs and a systematic overview of drivers and barriers to adopting blockchain for sustainability. The findings reveal that blockchain can have a positive impact on all 17 SDGs through technological innovations though some negative effects can occur and impede the achievement of certain objectives. 73 positive and 10 negative linkages between blockchain adoption and the 17 SDGs as well as 45 factors that drive or hinder blockchain adoption for the achievement of SDGs have been identified. Research gaps to overcome the barriers and enhance blockchain’s positive impacts have also been identified. The findings may help managers in evaluating the applicability and tradeoffs and policymakers in making supportive measures to facilitate sustainability using blockchain. </p>
Bidara leaf extract (Ziziphus mauritiana) inhibits Metalloproteinase-1 increase and collagen decrease in female Wistar rat skin exposed to Ultraviolet-B and cigarette smoke
Authors: Anggraeny Citra , Wiraguna Anak Agung Gde Putra , Pinatih Gde Ngurah Indraguna 
Published: January 2022

Background
Exposure to cigarette smoke and ultraviolet-B can activate enzymes that degrade collagen and inhibit its production through increased levels of MMP-1. Bidara leaves with high content of flavonoids and tannins may prevent damage caused by free radicals. This study aimed to prove the effect of Bidara leaf extract in inhibiting the increase in MMP-1 levels and collagen reduction in female Wistar rat’s skin exposed to UV-B and cigarette smoke.

Methods
A randomized posttest-only control group design study was conducted on 30 female Wistar rats, aged 8-10 weeks, weighing 130-150 grams. The rats were divided into three groups: the group without treatment, the base cream, and the 7.5% Bidara leave extract groups. The last two groups were exposed to UV-B light and cigarette smoke. After four weeks of intervention, the back skin tissue was taken to assess collagen amount and MMP-1 levels. Comparative analysis was performed to see the difference between groups.

Results
The results showed that the mean levels of MMP-1 in the untreated group were lowest, followed by the Bidara leaf extract cream and the base cream group. The mean collagen amount of the Bidara leaf extract group was the highest, followed by the base cream and the untreated group. The analysis showed a significant difference in the mean levels of MMP-1 and collagen amount between groups (p<0.05).

Conclusion
The 7.5% Bidara leaf extract cream inhibited the increase in MMP-1 levels and decreased collagen in female Wistar rats exposed to UV-B light and cigarette smoke.
Pengaruh Motivasi Usaha dan Kemampuan Usaha terhadap Keberhasilan Usaha di UMKM Pengolahan Pisang Kelurahan Rowosari, Tembalang Semarang
Authors: Aisyah Nur Wastuti  , Sumekar Wulan , Prasetyo Agus Subhan 
Published: January 2022

Kelurahan Rowosari Kecamatan Tembalang menjadi salah satu daerah dengan pertumbuhan usaha yang cukup pesat di Kota Semarang. Dengan adanya potensi tersebut dan melimpahnya produksi pisang menjadikan hal ini sebuah peluang untuk mengembangkan usaha di sektor makanan terutama berbahan dasar komoditas pisang. Kelompok UMKM Mekarsari merupakan salah satu kelompok yang cukup aktif dalam mengembangkan usaha olahan makanannya terutama olahan berbahan dasar pisang yang mudah didapatkan dan pasarnya cukup luas. Namun, karena banyaknya pengusaha yang menekuni usaha dibidang ini maka persainganpun semakin ketat sehingga terdapat kesenjangan antar pengusaha satu dengan lainnya. Tujuan dari penelitian ini untuk: 1) Mendeskripsikan pengaruh motivasi dan kemampuan usaha terhadap keberhasilan berwirausaha. 2) Menganalisis pengaruh tingkat motivasi dan kemampuan usaha terhadap keberhasilan berwirausaha. Penelitian berlokasi di 32 UMKM pengolahan pisang bernama UMKM Mekarsari di Kelurahan Rowosari, Kecamatan Tembalang, Semarang. Metode yang digunakan merupakan metode studi kasus dengan pendekatan secara kuantitatif. Penentuan responden menggunakan metode sensus dengan jumlah responden sebanyak 37 pekerja dan pengusaha olahan pisang. Metode pengumpulan data diambil dengan melakukan wawancara dengan alat bantu kuesioner, observasi dan dokumentasi. Analisis data menggunakan analisis deskriptif dan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa 1) Sikap motivasi, kemampuan dan keberhasilan usaha tergolong tinggi. Growth pada motivasi usaha memiliki nilai paling tinggi diantara kedua faktor lainnya. Sedangkan untuk kemampuan usaha faktor pemasaran memiliki nilai paling tinggi, dan daya saing pada keberhasilan usaha memiliki nilai paling tinggi 2) Variabel motivasi dan kemampuan usaha berpengaruh nyata terhadap keberhasilan usaha secara simultan dengan nilai FHitung sebesar 7,966 3) UMKM Mekarsari dikatakan sudah layak dalam menjalankan usaha pengolahan pisangnya karena memiliki nilai R/C Ratio yang melebihi 1. Nilai tambah keempat produk pun cukup tinggi karena nilainya lebih dari 40% dan nilai keuntungan yang melebihi 50%.
Kata kunci : keberhasilan, kemampuan, motivasi, pisang, UMKM
DUALISM OF THE ARTISTIC SPACE IN VICTOR PELEVIN’S NOVEL “GENERATION ‘P’
Authors: Насер Мухамед Талха 
Published: January 2022

В статье поднимается проблема дуализма художественного пространства романа Виктора Пелевина «Generation “П”», которое представлено субъективной и объективной реальностью. Понятие «субъективная и объективная реальность» ввел в философский язык Д. И. Дубровский в 1968 году. Автор утверждает, что это понятие характерно для современной русской прозы. В работе наглядно иллюстрируется, как олицетворением художественного пространства потребительского общества становятся город Москва и средства масс-медиа (реклама, телевидение, мировая компьютерная сеть). Научная новизна работы заключается в том, что впервые художественное пространство романа рассматривается с точки зрения дуализма реальностей. Автор отмечает, что рецептивная эстетика романа состоит из интертекстуальных связей, рассчитанных на разные уровни восприятия. Исследование показало, что в произведении русского постмодернистаВ. Пелевина художественное пространство состоит не только из одного вещественного мира, но и из телевизионной и психоделической реальности. На границе двух реальностей в сознании главного героя возникают вавилонские ассоциации. Структура художественного пространства в романе обусловлена городской средой. Москва в романе впитывает «петербургский миф», автор подчеркивает тревожность городского пейзажа. Результаты исследования имеют практическое значение и могут быть использованы в вузовских курсах по истории современной литературы.
The article raises the problem of dualism of the artistic space of Victor Pelevin’s novel “Generation ‘P’”, which is represented by subjective and objective reality. The concept “subjective and objective reality” was introduced into the philosophical circulation by D. Dubrovsky in 1968. The author claims that this concept is characteristic of modern Russian prose. The work clearly illustrates how the city of Moscow and the mass media (advertising, television, world computer network) become the personification of the artistic space of the consumer society. The scientific novelty of the work lies in the fact that for the first time the artistic space of the novel is considered from the point of view of the dualism of realities. The author notes that the receptive aesthetics of the novel consists of intertextual connections designed for different levels of perception. The study showed that in the work of the Russian postmodernist V. Pelevin, the artistic space does not consist of one material world, but of television and psychedelic reality. On the border of two realities, Babylonian associations arise in the mind of the protagonist. The structure of the artistic space in the novel is determined by the urban environment. Moscow in the novel absorbs the “Petersburg myth”, the author emphasizes the uneasiness of the urban landscape. The research results are of practical importance and can be used in university courses on the history of modern literature
EXERCISES FOR FORMING FOREIGN LANGUAGE PROFESSIONAL COMMUNICATION SKILLS IN DOCTORS-TO-BE
Authors: Царская Татьяна Сергеевна 
Published: January 2022

В характеристиках обобщенных трудовых функций в профессиональном стандарте врачей указывается на необходимость их участия во всероссийских и международных съездах, конгрессах, конференциях, симпозиумах, стажировках и других образовательных мероприятиях, что предполагает наличие устойчивых навыков владения иностранным языком для профессионального общения с зарубежными коллегами. В данном контексте формирование навыков иноязычного профессионального общения у будущих врачей является актуальным и обусловливается систематическим выполнением в определенной последовательности многократных действий, именуемых упражнениями. Автор данной работы актуализирует систему упражнений в качестве дидактического средства формирования навыков иноязычного профессионального общения у будущих врачей. На основе теоретического анализа научных литературных источников систематизированы разные подходы к классификации упражнений, их типы, виды.
The characteristics of generalized labor functions in the professional standard of doctors indicate the need to participate in all-Russian and international congresses, conferences, symposia, training courses and other educational events. which conditions having stable skills of proficiency in a foreign language for professional communication with foreign colleagues. In this context, the formation of foreign language professional communication skills I doctors-to-be is relevantand conditioned by the systematic doing in a certain sequence of repeated actions-exercises. The system of exercises as one of the didactic means in the problem of forming foreign language professional communication skills in doctors-to-be is actualized. The author systematizes different approaches classifying the exercises for the formation of foreign language professional communication skills in doctors-to-be according to theoretical analysis of scientific literary sources.
From Menstruation to the Menopause
Authors: Tomlinson Maria Kathryn 
Published: January 2022

This book examines the representation of the female fertility cycle in contemporary Algerian, Mauritian, and French women’s writing. It focuses on menstruation, childbirth, and the menopause whilst also incorporating experiences such as miscarriage and abortion. This study frames its analysis of contemporary women’s writing in French by looking back to the pioneering work of the second-wave feminists. Second-wave feminist texts were the first to break the silence on key aspects of female experience which had thus far been largely overlooked or considered taboo. Second-wave feminist works have been criticised for applying their ‘universal’ theories to all women, regardless of their ethnicity, socio-economic status, or sexuality. This book argues that contemporary women’s writing has continued the challenge against normative perceptions of the body that was originally launched by the second-wave feminists, whilst also taking a more nuanced, contextual and intersectional approach to corporeal experience. The cross-cultural and interdisciplinary approach of this book is informed not only by critics of the second-wave feminist movement but also by sociological studies which consider how women’s bodily experiences are shaped by socio-cultural context.
Fine-scale abundance of rocky shore macroalgae species with distribution limits in NW Iberia in 2020/2021
Authors: Pereira Joana , Monteiro Catia , Seabra Rui , Lima Fernando 
Published: January 2022

Climate change has been increasing at an unprecedented rate in the last decades. Warming has been causing a variety of impacts in marine ecosystems, including shifts in the geographical ranges of species. The North-western Iberian Peninsula coast is particularly interesting to study distribution shifts as it features a strong latitude thermal gradient, establishing a biogeographical transitional region where several cold- and warm-adapted species have their equatorward or poleward distributions. In the early 2000s, it appeared that while warm-water species were already responding to warming, cold-water species did not display a coherent response. It is now necessary to gather fresh data on the distribution of the same group of species to understand if current patterns of change confirm or deny those observed back then, which may give us important clues about the mechanisms setting species limits in the area.
This study aims at providing a fine-scale description of the occurrence of intertidal macroalgae species in the rocky shores of the North-western Iberian coast. Specifically, the spatial distribution and semi-quantitative abundance of 34 native and invasive species were assessed at 70 wave-exposed locations. This included 19 species of cold-water affinity, 10 species of warm-water affinity and 5 neutral species. When contrasted with historical observations, these new data can be used to quantify and map biodiversity change in the region, as well as help understanding the mechanisms constraining species distributions.
L’industrie de la télévision
Authors: Rebillard Franck , Noûs Camille 
Published: January 2022

Prenant appui sur les articles composant le dossier Télévision : industries et programmes, ce texte de présentation revient plus généralement sur les principales évolutions socio-économiques traversant la filière depuis le début du XXI e siècle. Sont ainsi passées en revue la logique de groupe accompagnant la multiplication des chaînes avec la télévision numérique terrestre (TNT) ; les stratégies attenantes de programmation de type narrowcasting puisant dans les formats transnationaux de séries et de télé-réalité ; le renforcement de la tendance à l’externalisation de la production, variant toutefois selon les types de programmes ; la polyvalence des tâches incombant aux personnels journalistiques comme artistiques et devant composer avec une emprise de la technique s’étendant jusqu’aux publics. Le tout dessine un double mouvement de fragmentation et de recomposition pour la filière de la télévision, bousculée de façon plus globale par l’environnement numérique.
Légitimité parentale et idéal de résistance aux écrans
Authors: Balleys Claire 
Published: January 2022

Cet article s’intéresse aux postures et aux relations parentales face aux usages des écrans dans la famille. À partir des résultats d’une enquête croisant systématiquement les discours et les perceptions des enfants comme des parents, vis-à-vis des usages de chaque membre des 15 familles rencontrées, nous montrons comment les pratiques numériques et leurs perceptions sont au cœur d’enjeux de distinction pour les parents. Alors que les usages juvéniles des écrans et leur régulation parentale sont beaucoup étudiés, nous proposons un double déplacement : 1. Mettre à jour l’inscription de la médiation parentale numérique dans les normes contemporaines de la « bonne parentalité », ce qui implique de l’étudier sous l’angle des appartenances sociales de la classe et du genre, et 2. Mettre à jour les usages des adultes et leurs perceptions, c’est-à-dire les agacements, crispations et conflits qu’ils alimentent au sein des couples et entre ex-conjoints. C’est donc sur l’axe horizontal de la socialisation parentale et conjugale que l’argument est construit, afin de montrer comment les discours sur la place des écrans dans les familles sont des marqueurs d’appartenances identitaire et sociale. Parler des usages, c’est opérer un travail de légitimation (de soi) ou au contraire de dénigrement (des autres), en fonction de sa position dans un système social stratifié et genré.