bluuebunny/crossref_metadata_2025_split huggingface dataset:
The case of sleeping beauties in nanotechnology: a study of potential breakthrough inventions in emerging technologies
Authors: Tur Elena M. , Bourelos Evangelos , McKelvey Maureen 
Published: May 2022

AbstractThis study aims to determine whether innovation depends on long-term patterns of interactions in technology and science, using patents in nanotechnology. The previous literature has distinguished between a technology’s degree of novelty (science-base) and degree of technological impact, highlighting that links to the science-base will lead to more breakthrough inventions, due to distant recombinations. We extend the debate by distinguishing two types of science linkages, “direct and strong science-base” and “indirect and more diverse science-base.” To find long-term patterns, we developed an empirical strategy to study nanotechnology patents through the metaphor of “sleeping beauties”, e.g., delayed recognition and high impact. We show that sleeping beauties occur more frequently in nanotechnology than in the general population of patents, so nanotechnology is an emerging technology that may delay breakthrough inventions. As expected, both types of science linkages create a higher impact. Contrary to expectations, however, neither “direct and strong science-base” (proxied by university ownership) nor “indirect and more diverse science-base” (proxied by the non-patent literature) are significant. Although this emerging technology has many science linkages, these do not cause a delayed impact. Control variables of IPC application class and company ownership do matter. We conceptualize that these are typical characteristics when firms combine several technologies for industrial innovation. Among other contributions, we propose that the non-patent literature should not be considered a proxy for science linkages in general, but instead this reflects a search amongst various types of codified as well as informal technological and scientific knowledge. We suggest that the long-term patterns of delayed recognition and high impact in science-based technologies may require the firms to recombine multiple technologies, specializations, and industrial applications in order to do industrial invention.
Lactiplantibacillus plantarum E51 protects against Clostridioides difficile-induced damages on Caco-2 intestinal barrier functions
Authors: Jeng Huey-Sheng , Yan Tsong-Rong 
Published: May 2022

AbstractClostridioides difficile (C. difficile) infection is associated with high morbidity and mortality. This study aimed to evaluate the protective effect of Lactiplantibacillus plantarum E51 (L. plantarum E51) on C. difficile infection using the Caco-2 monolayer in vitro model. Caco-2 cells were infected with C. difficile in the presence/absence of L. plantarum E51 or Lacticaseibacillus rhamnosus GG (LGG). Caco-2 intestinal barrier functions, such as monolayer integrity, IL-8 secretion, and tight junction protein expression, were quantified to investigate the extent to which L. plantarum E51 protected against C. difficile infection in vitro. Furthermore, inhibition of C. difficile adhesion to Caco-2 cells by L. plantarum E51 was explored using competition, exclusion, and displacement assays. The results indicated that L. plantarum E51 inhibited C. difficile growth, ameliorated C. difficile-caused decrease in transepithelial/ transendothelial electrical resistance, attenuated C. difficile-induced IL8 secretion, and upregulated claudin-1 protein expression that was inhibited by C. difficile. Moreover, L. plantarum E51 suppressed C. difficile adhesion to Caco-2 cells. In conclusion, these findings demonstrated that L. plantarum E51 substantially protected against C. difficile-induced damages on intestinal barrier functions in Caco-2 cells. The probiotic potential of L. plantarum E51 against C. difficile infection warrants further investigation.
Evolution of chemically induced cracks in alkali feldspar: thermodynamic analysis
Authors: Abart Rainer , Petrishcheva Elena , Habler Gerlinde , Sutter Christoph , Fischer Franz Dieter , Predan Jozef , Kegl Marko , Rammerstorfer Franz G. 
Published: May 2022

AbstractA system of edge cracks was applied to polished (010) surfaces of K-rich gem-quality alkali feldspar by diffusion-mediated cation exchange between oriented feldspar plates and a Na-rich NaCl–KCl salt melt. The cation exchange produced a Na-rich layer at and beneath the specimen surface, and the associated strongly anisotropic lattice contraction lead to a tensile stress state at the specimen surface, which induced fracturing. Cation exchange along the newly formed crack flanks produced Na-enriched diffusion halos around the cracks, and the associated lattice contraction and tensile stress state caused continuous crack growth. The cracks nucleated with non-uniform spacing on the sample surface and quickly attained nearly uniform spacing below the surface by systematic turning along their early propagation paths. In places, conspicuous wavy cracks oscillating several times before attaining their final position between the neighboring cracks were produced. It is shown that the evolution of irregularly spaced towards regularly spaced cracks including the systematic turning and wavyness along the early propagation paths maximizes the rate of free energy dissipation in every evolutionary stage of the system. Maximization of the dissipation rate is suggested as a criterion for selection of the most probable evolution path for a system undergoing chemically induced diffusion mediated fracturing in an anisotropic homogeneous brittle material.
A chondrule formation experiment aboard the ISS: microtomography, scanning electron microscopy and Raman spectroscopy on Mg$$_2$$SiO$$_4$$ dust aggregates
Authors: Spahr Dominik , Koch Tamara E. , Merges David , Bayarjargal Lkhamsuren , Genzel Philomena-Theresa , Christ Oliver , Wilde Fabian , Brenker Frank E. , Winkler Björn 
Published: May 2022

AbstractWe performed an experiment under long-term microgravity conditions aboard the International Space Station (ISS) to obtain information on the energetics and experimental constraints required for the formation of chondrules in the solar nebula by ’nebular lightning’. As a simplified model system, we exposed porous forsterite (Mg$$_2$$

2

SiO$$_4$$

4

) dust particles to high-energetic arc discharges. The characterization of the samples after their return by synchrotron microtomography and scanning electron microscopy revealed that aggregates had formed, consisting of several fused Mg$$_2$$

2

SiO$$_4$$

4

particles. The partial melting and fusing of Mg$$_2$$

2

SiO$$_4$$

4

dust particles under microgravity conditions leads to a strong reduction of their porosity. The experimental outcomes vary strongly in their appearance from small spherical melt-droplets ($$\varnothing \approx$$

∅
≈

90 µm) to bigger and irregularly shaped aggregates ($$\varnothing \approx$$

∅
≈

350 µm). Our results provided new constraints with respect to energetic aspects of chondrule formation and a roadmap for future and more complex experiments on Earth and in microgravity conditions.
The aging immune system in Alzheimer’s and Parkinson’s diseases
Authors: Heavener Kelsey S. , Bradshaw Elizabeth M. 
Published: May 2022

AbstractThe neurodegenerative diseases Alzheimer’s disease (AD) and Parkinson’s disease (PD) both have a myriad of risk factors including genetics, environmental exposures, and lifestyle. However, aging is the strongest risk factor for both diseases. Aging also profoundly influences the immune system, with immunosenescence perhaps the most prominent outcome. Through genetics, mouse models, and pathology, there is a growing appreciation of the role the immune system plays in neurodegenerative diseases. In this review, we explore the intersection of aging and the immune system in AD and PD.
A Moiré interference pattern formation of magnetic nanoparticles by rotational magnetic field controlled interfacial self-assembly
Authors: Han Yuexia , Fan Fengguo , PengWang  , Liu Dan , Hu Fengxia , Zhu Pengfei , Sun Jianfei 
Published: May 2022

Abstract‘Magic-angled’ structure currently attracts increasing attention from condensed matter physics due to its amazing performance in superconductivity of graphene. The similar pattern formation of nanoparticles will bring about novel physics in nanoscale that causes the next generation nanodevices. However, it remains a challenging task to acquire such patterns by self-assembly process. In this article, we reported a Moiré interference pattern formation of magnetic nanoparticles regulated by a rotational magnetic field. The colloidal concentration, the strength, and the frequency of magnetic field were found to affect the pattern formation. The mechanism lied in a two-step process. First, the magnetic nanoparticles formed bilayers of superlattice driven by hydrophobic interaction of interfacial self-assembly. Then, the bilayers of superlattice yielded asynchronous rotational displacement resulting from the magnetic force so that the Moiré interference pattern of nanoparticles formed. This fabrication methodology based on the field-controlled self-assembly provided a novel and simple means to get ‘magic angled’ structures in nanoscale that will enrich the physical understanding of nanotechnology.
Change in Precipitation over the Tibetan Plateau Projected by Weighted CMIP6 Models
Authors: Zhao Yin , Zhou Tianjun , Zhang Wenxia , Li Jian 
Published: May 2022

AbstractPrecipitation over the Tibetan Plateau (TP) is important to local and downstream ecosystems. Based on a weighting method considering model skill and independence, changes in the TP precipitation for near-term (2021–40), mid-term (2041–60) and long-term (2081–2100) under shared socio-economic pathways (SSP1-1.9, SSP1-2.6, SSP2-4.5, SSSP3-7.0, SSP5-8.5) are projected with 27 models from the latest Sixth Phase of the Couple Model Intercomparison Project. The annual mean precipitation is projected to increase by 7.4%–21.6% under five SSPs with a stronger change in the northern TP by the end of the 21st century relative to the present climatology. Changes in the TP precipitation at seasonal scales show a similar moistening trend to that of annual mean precipitation, except for the drying trend in winter precipitation along the southern edges of the TP.Weighting generally suggests a slightly stronger increase in TP precipitation with reduced model uncertainty compared to equally-weighted projections. The effect of weighting exhibits spatial and seasonal differences. Seasonally, weighting leads to a prevailing enhancement of increase in spring precipitation over the TP. Spatially, the influence of weighting is more remarkable over the northwestern TP regarding the annual, summer and autumn precipitation. Differences between weighted and original MMEs can give us more confidence in a stronger increase in precipitation over the TP, especially for the season of spring and the region of the northwestern TP, which requires additional attention in decision making.
ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and Th2 Immune Responses
Authors: Jaiswal Anil Kumar , Mishra Amarjit 
Published: May 2022

Abstract
Purpose
ADAMTS7 is a secreted metalloproteinase enzyme and proteoglycan associated with the early progression of coronary artery disease. However, there is limited information regarding the role of ADAMTS7 in lung adaptive immunity and inflammation. Thus, we sought to assess whether ADAMTS7 expression in the lung modulates house dust mite (HDM)-induced airway inflammation and Th2 immune response.

Methods
The role of ADAMTS7 in HDM-induced airway disease was assessed in ADAMTS7-deficient (ADAMTS7−/−) mice and compared with the wild-type control mice by flow cytometry, ELISA, and histopathology. Furthermore, the antigen priming capability of dendritic cells (DC) was determined ex vivo by employing coculture with CD4+ OT-II cells.

Results
ADAMTS7−/− mice develop an augmented eosinophilic airway inflammation, mucous cell metaplasia, and increased Th2 immune response to inhaled HDM. In addition, allergen uptake by lung DC and migration to draining mediastinal lymph node were significantly increased in ADAMTS7−/− mice, which shows an enhanced capacity to mount allergen-specific T-cell proliferation and effector Th2 cytokine productions. We propose that the mechanism by which ADAMTS7 negatively regulates DC function involves attenuated antigen uptake and presentation capabilities, which reduces allergic sensitization and Th2 immune responses in the lung.

Conclusion
In aggregate, we provide compelling evidence that ADAMTS7 plays a pivotal role in allergic airway disease and Th2 immunity and would be an attractive target for asthma.
Undifferentiated pleomorphic sarcoma of the breast with neoplastic fever: case report and genomic characterization
Authors: Gambichler Thilo , Horny Kai , Mentzel Thomas , Stricker Ingo , Tannapfel Andrea , Scheel Christina H. , Behle Bertold , Quast Daniel R. , Lee Yi-Pei , Stücker Markus , Susok Laura , Becker Jürgen C. 
Published: May 2022

Abstract
Purpose
Primary breast sarcomas are extraordinary rare, in particular undifferentiated pleomorphic sarcoma (UPS). UPS with neoplastic fever (UPS-NF) of the breast has not been reported yet. Here, we present an extended UPS-NF of the breast including its comprehensive molecular workup.

Methods
A 58-year-old female presented with general malaise, fever spikes, weight loss, and a massively swollen left breast. C-reactive protein and blood leucocytes were significantly increased. However, repeated blood cultures and smears were all sterile. Histopathology of the abscess-forming tumor revealed an undifferentiated malignancy with numerous of tumor giant cells as well as spindle-shaped cells with nuclear pleomorphism and hyperchromasia. Immunohistochemistry demonstrated partial, patchy desmin staining and weak heterogonous neuron-specific enolase immunoreactivity of tumor cells, but a focal staining for Melan-A.

Results
Neither common melanoma driver mutations nor an ultraviolet mutational signature was detected by whole genome sequencing. Using FISH and RT-PCR we also excluded translocations characteristic for clear cell sarcoma. Thus, the diagnosis of inflammatory UPS-NF of the breast was considered highly probable. Despite a complete mastectomy, the tumor recurred after only three months. This recurrence was treated with a combination of ipilimumab and nivolumab based on the primary tumor’s TPS score for PD-L1 of 30%. After an initial response, however, the tumor was progressive again.

Conclusion
We describe here the first case of UPS-NF of the breast, which shows great clinical and histopathologic resemblances to previously reported UPS-NF of other anatomic localizations.
Impact of intra-abdominal insufflation pressure on gas leakage occurring during laparoscopy
Authors: Dalli Jeffrey , Montminy Tess , Ferguson Makenzie , Khan Mohammad Faraz , Nolan Kevin , Cahill Ronan A. 
Published: May 2022

Abstract
Introduction
The advent of the COVID-19 pandemic led to recommendations aimed at minimizing the risk of gas leaks at laparoscopy. As this has continuing relevance including regarding operating room pollution, we empirically quantified carbon dioxide (CO2) leak jet velocity (important for particle propulsion) occurring with different instruments inserted into differing trocars repeated across a range of intra-abdominal pressures (IAPs) and modern insufflators in an experimental model.

Method
Laparoscopic gas plume leak velocity (metres/second) was computationally enumerated from schlieren optical flow videography on a porcine cadaveric laparoscopic model with IAPs of 4–5, 7–8, 12–15 and 24–25 mmHg (repeated with 5 different insufflators) during simulated operative use of laparoscopic clip appliers, scissors, energy device, camera and staplers as well as Veres needle (positive control) and trocar obturator (negative control) in fresh 5 mm and 12 mm ports.

Results
Close-fitting solid instruments (i.e. cameras and obturators) demonstrated slower gas leak velocities in both the 5 mm and 12 mm ports (p = 0.02 and less than 0.001) when compared to slimmer instruments, however, hollow instrument designs were seen to defy this pattern with the endoscopic linear stapler visibly inducing multiple rapid jests even when compared to similarly sized clip appliers (p = 0.03). However, on a per device basis the operating instrumentation displayed plume speeds which did not vary significantly when challenged with varying post size, IAP and a range of insufflators.

Conclusion
In general, surgeon's selection of instrument, port or pressure does not usefully mitigate trocar CO2 leak velocity. Instead better trocar design is needed, helped by a fuller understanding of trocar valve mechanics via computational fluid dynamics informed by relevant surgical modelling.
Robot-assisted minimally invasive esophagectomy (RAMIE) vs. hybrid minimally invasive esophagectomy: propensity score matched short-term outcome analysis of a European high-volume center
Authors: Babic Benjamin , Müller Dolores T. , Jung Jin-On , Schiffmann Lars M. , Grisar Paula , Schmidt Thomas , Chon Seung-Hun , Schröder Wolfgang , Bruns Christiane J. , Fuchs Hans F. 
Published: May 2022

Abstract
Introduction
Transthoracic esophagectomy is a highly complex and sophisticated procedure with high morbidity rates and a significant mortality. Surgical access has consistently become less invasive, transitioning from open esophagectomy to hybrid esophagectomy (HE) then to totally minimally invasive esophagectomy (MIE), and most recently to robot-assisted minimally invasive esophagectomy (RAMIE), with each step demonstrating improved patient outcomes. Aim of this study with more than 600 patients is to complete a propensity-score matched comparison of postoperative short-term outcomes after highly standardized RAMIE vs. HE in a European high volume center.

Patients and Methods
Six hundred and eleven patients that underwent transthoracic Ivor–Lewis esophagectomy for esophageal cancer between May 2016 and May 2021 were included in the study. In January 2019, we implemented an updated robotic standardized anastomotic technique using a circular stapler and ICG (indocyanine green) for RAMIE cases. Data were retrospectively analyzed from a prospectively maintained IRB-approved database. Outcomes of patients undergoing standardized RAMIE from January 2019 to May 2021 were compared to our overall cohort from May 2016–April 2021 (HE) after a propensity-score matching analysis was performed.

Results
Six hundred and eleven patients were analyzed. 107 patients underwent RAMIE. Of these, a total of 76 patients underwent a robotic thoracic reconstruction using the updated standardized circular stapled anastomosis (RAMIE group). A total of 535 patients underwent HE (Hybrid group). Seventy patients were propensity-score matched in each group and analysis revealed no statistically significant differences in baseline characteristics. RAMIE patients had a significantly shorter ICU stay (p = 0.0218). Significantly more patients had no postoperative complications (Clavien Dindo 0) in the RAMIE group [47.1% vs. 27.1% in the HE group (p = 0.0225)]. No difference was seen in lymph node yield and R0 resection rates. Anastomotic leakage rates when matched were 14.3% in the hybrid group vs. 4.3% in the RAMIE group (p = 0.07).

Conclusion
Our analysis confirms the safety and feasibility of RAMIE and HE in a large cohort after propensity score matching. A regular postoperative course (Clavien–Dindo 0) and a shorter ICU stay were seen significantly more often after RAMIE compared to HE. Furthermore it shows that both procedures provide excellent short-term oncologic outcomes, regarding lymph node harvest and R0 resection rates. A randomized controlled trial comparing RAMIE and HE is still pending and will hopefully contribute to ongoing discussions.
Model-based fleet deployment in the IoT–edge–cloud continuum
Authors: Song Hui , Dautov Rustem , Ferry Nicolas , Solberg Arnor , Fleurey Franck 
Published: May 2022

AbstractWith the increasing computing and networking capabilities, IoT devices and edge gateways have become part of a larger IoT–edge–cloud computing continuum, where processing and storage tasks are distributed across the whole network hierarchy, not concentrated only in the cloud. At the same time, this also introduced continuous delivery practices to the development of software components for network-connected gateways and sensing/actuating nodes. These devices are placed on end users’ premises and are characterized by continuously changing cyber-physical contexts, forcing software developers to maintain multiple application versions and frequently redeploy them on a distributed fleet of devices with respect to their current contexts. Doing this correctly and efficiently goes beyond manual capabilities and requires an intelligent and reliable automated solution. This paper describes a model-based approach to automatically assigning multiple software deployment plans to hundreds of edge gateways and connected IoT devices implemented in collaboration with a smart healthcare application provider. From a platform-specific model of an existing edge computing platform, we extract a platform-independent model that describes a list of target devices and a pool of available deployment plans. Next, we use constraint solving to automatically assign deployment plans to devices at once with respect to their specific contexts. The result is transformed back into the platform-specific model and includes a suitable deployment plan for each device, which is then consumed by our engine to deploy software components not only on edge gateways but also on their downstream IoT devices with constrained resources and connectivity. We validate the approach with a fleet deployment prototype integrated into a DevOps toolchain used by the partner application provider. Initial experiments demonstrate the viability of the approach and its usefulness in supporting DevOps for edge and IoT software development.
Comparison of two different mindfulness interventions among health care students in Finland: a randomised controlled trial
Authors: Repo Saara , Elovainio Marko , Pyörälä Eeva , Iriarte-Lüttjohann Mónica , Tuominen Tiina , Härkönen Tiina , Gluschkoff Kia , Paunio Tiina 
Published: May 2022

AbstractWe investigated the short- and long-term effects of two different evidence-based mindfulness training on students’ stress and well-being. A randomised controlled trial with three measurement points (baseline, post-intervention, and 4 months post-intervention) was conducted among undergraduate students of medicine, dentistry, psychology, and logopaedics at the University of Helsinki. The participants were randomly assigned into three groups: (1) face-to-face mindfulness training based on the Mindfulness Skills for Students course (n = 40), (2) a web-based Student Compass program using Mindfulness and Acceptance and Commitment therapy (n = 22), and (3) a control group that received mental health support as usual (n = 40). The primary outcome was psychological distress measured using the Clinical Outcomes in Routine Evaluation Outcome Measure (CORE-OM). Secondary outcomes included hair cortisol concentrations and a wide range of well-being indicators. Psychological distress increased in all the groups from baseline to post-intervention, but significantly less so in the intervention groups than in the control group. At 4-month follow-up, were found no differences between the primary outcomes of the control and intervention groups, but the participants who continued practising mindfulness at least twice a week were less stressed than the others. Our results suggest that participating in a mindfulness course may mitigate health care students’ psychological distress during the academic year, but only if the participants continue practising mindfulness at least twice a week.