bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genes Relating to Biological Processes of Endometriosis: Expression
Changes Common to a Mouse Model and Patients
Authors: Iwasaki Shiho , Kaneda Katsuyuki 
Published: September 2022

AbstractEndometriosis is one of the most common gynecological diseases in women of
reproductive age. Retrograde menstruation is considered a major reason for the
development of endometriosis. The syngeneic transplantation mouse model is an
endometriosis animal model that is considered to mimic retrograde menstruation.
However, it remains poorly understood which genetic signatures of endometriosis
are reflected in this model. Here, we employed an in vivo syngeneic mouse
endometriosis model and identified differentially expressed genes (DEGs) between
the ectopic and eutopic tissues using microarray analysis. Three gene expression
profile datasets, GSE5108, GSE7305, and GSE11691, were downloaded from the Gene
Expression Omnibus database and DEGs between ectopic and eutopic tissues from
the same patients were identified. Gene ontology analysis of the DEGs revealed
that biological processes including cell adhesion, the inflammatory response,
the response to mechanical stimulus, cell proliferation, and extracellular
matrix organization were enriched in both the model and patients. Of the 195
DEGs common to the model and patients, 154 showed the same expression pattern,
and 28 of these 154 DEGs came up when PubMed was searched for each gene along
with the terms “endometriosis” and
“development”. This is the first comparison of the DEGs of the
mouse syngeneic endometriosis model and those of patients, and we identified the
biological processes common to the model and patients at the transcriptional
level. This model may be useful to evaluate the efficacy of drugs which target
these biological processes.
Individuelle Unterstützung von psychisch beeinträchtigten Jugendlichen im Übergang zwischen den Hilfesystemen
Authors: Gindele Verena , Herzig Meike , Hartl Johann , Neumann Sebastian , Esch Lena-Maria , Hiller Therese , Witt Andreas , Fegert Jörg M. , Böge Isabel 
Published: September 2022

ZUSAMMENFASSUNGZiel des Teilprojekts „Teilhabeinstrument Dazugehören BaWü Adoleszenz (TiDA)“ im Projekt „Dazugehören BaWü“ ist die Entwicklung eines digitalen Instruments, mit dem (drohende) Teilhabebeeinträchtigungen bei Jugendlichen und jungen Erwachsenen (zwischen 16 und 27 Jahren) zuverlässig eingeschätzt werden können. In enger Zusammenarbeit mit 4 Praxisstandorten entsteht auf Grundlage der gesetzlichen Vorgaben des SGB VIII und des ergänzenden Kinder- und Jugendstärkungsgesetzes (KJSG) und des Bundesteilhabegesetztes (BTHG) sowie aufbauend auf den Desideraten aus der Praxis ein Instrument für die Einschätzung der Teilhabebeeinträchtigung von jungen Menschen. Außerdem soll mit Hilfe dieses Instruments der Übergang von der Jugendhilfe in das Hilfesystem für Erwachsene erleichtert werden. In diesem Artikel wird beschrieben, auf welche Grundlagen bei der Entwicklung des Instruments und der Übergangsplattform zurückgegriffen, wie bei der Entwicklung vorgegangen und wie die Anforderungen aus den gesetzlichen Vorgaben und aus der Praxis umgesetzt wurden.
„Der Bedarf ist oft nicht differenziert aufgeschlüsselt“ Transition junger Erwachsener mit seelischer Beeinträchtigung von der Jugendhilfe in die Eingliederungshilfe
Authors: Esch Lena-Maria , Hiller Therese , Gindele Verena , Herzig Meike , Hartl Johann , Neumann Sebastian , Böge Isabel , Fegert Jörg M. , Witt Andreas 
Published: September 2022

ZUSAMMENFASSUNGDieser Artikel beschäftigt sich mit der viel diskutierten Übergangsproblematik junger Erwachsener mit seelischer Beeinträchtigung aus der Jugend- in die Eingliederungshilfe und beschreibt die hinderlichen und förderlichen Faktoren in diesem Transitionsprozess. Außerdem werden unterschiedliche Möglichkeiten diskutiert, wie ein Übergabeinstrument von der Jugend- in die Eingliederungshilfe gestaltet werden kann, um den Übergang für die Fachkräfte sowie die Leistungsberechtigen reibungsloser zu gestalten. Dabei wird die „große Lösung“, die im Jahr 2028 gesetzlich verpflichtend werden soll, in den Blick genommen. Hierzu wurden in 11 leitfadengestützten Experteninterviews mit 13 Fachkräften aus der Jugend- und Eingliederungshilfe in 4 Landkreisen in Baden-Württemberg Primärdaten erhoben, deren qualitative Auswertung in diesem Artikel ihre Darstellung findet.Zusammenfassend fordern die Fachkräfte aus der Praxis ein übersichtliches und einheitliches Bedarfseinschätzungs- und Übergabeinstrument, das sowohl den Fachkräften der Jugendhilfe als auch den Leistungsberechtigten klare Handlungsrichtlinien zum Vorgehen in diesem Transitionsprozess gibt und der Eingliederungshilfe die erforderlichen Informationen liefert.
Hör- und Lebensalter-bezogene Wortproduktion von Kindern mit Cochlea-Implantat
Authors: Glaubitz Cynthia , Geiss Katrin T. , Hoppe Ulrich 
Published: September 2022

Zusammenfassung
Hintergrund Eine frühe bilaterale Cochlea-Implantat (CI)-Versorgung stellt für kongenital gehörlose Kinder eine günstige Spracherwerbsbedingung dar.
Die vorliegende Studie fokussiert die Wortproduktion dieser Kinder mit einem Vergleich von
Lebens- und Höralter-bezogenen Leistungen und beleuchtet diese bezüglich
Zusatzbeeinträchtigung, Mehrsprachigkeit und Versorgungsalter.
Methodik Die Daten 62 bilateral versorgter Kinder
(Versorgungsalter M=12,1; SD=6,2 Monate) wurden retrospektiv ausgewertet. Die mit dem Aktiven Wortschatztest für 3–5-jährige Kinder – Revision erhobenen
Leistungen wurden hinsichtlich Lebens- und Höralter verglichen. Gruppenvergleiche und
Korrelationsanalysen zu Mehrsprachigkeit, Zusatzbeeinträchtigungen und Versorgungsalter wurden
durchgeführt.
Ergebnisse Die Leistungen waren signifikant besser in der
Beurteilung nach Höralter. Inner- oder oberhalb der Norm lagen hiernach mehr als 50%, für das
Lebensalter rund 37%. Die beobachteten Leistungsunterschiede bei Mehrsprachigkeit und
Zusatzbeeinträchtigung waren nur für beiderlei betroffene Kinder signifikant. Die Leistungen
einsprachiger Kinder ohne Zusatzbeeinträchtigung waren nicht bedeutsam mit dem
Versorgungsalter assoziiert.
Schlussfolgerung CI-versorgte Kinder können im Alter von 3–5
Jahren über einen angemessenen aktiven Wortschatz verfügen. Besondere Herausforderungen
ergeben sich bei Zusatzbeeinträchtigung und Mehrsprachigkeit, welche in fortführenden Studien
genauerer Definitionen bedürfen. Die Auswertung standardisierter Tests nach Lebens- und
Höralter erlaubt eine differenzierte Beurteilung des Entwicklungsstandes. Therapieplanung und
Elternberatung können davon profitieren.
Learning curve for esophageal peroral endoscopic myotomy: a systematic review and meta-analysis
Authors: Puli Srinivas R. , Wagh Mihir S. , Forcione David , Gopakumar Harishankar 
Published: September 2022

Background and study aims Peroral endoscopic myotomy (POEM) is a minimally invasive endoscopic procedure for the treatment of achalasia and certain spastic esophageal motility disorders, delivering excellent results in experienced hands. However, this complex and technically challenging procedure requires advanced endoscopic skills. The aim of this study was to conduct a systematic review and meta-analysis of current data to evaluate the learning curve for POEM in new adopters of this technique.
Methods Electronic databases (PubMed, Embase, and Cochrane Library) from inception to November 2021 were searched for publications addressing the learning curve in POEM. Pooling was conducted by both fixed- and random-effects models. Secondary outcomes reviewed were clinical success defined by Eckardt score ≤ 3 when available and adverse events.
Results Eight studies involving 1904 patients met the inclusion criteria. In the pooled analysis, new adopters of POEM attained proficiency at a mean of 24.67 procedures (95 %CI 23.93 to 25.41). Once proficiency was achieved, the pooled total procedure time plateaued at a mean of 85.38 minutes (95 %CI 81.48 to 89.28), the pooled mean procedure time per centimeter of myotomy was 6.25 minutes (95 %CI 5.69 to 6.82), and the pooled mean length of myotomy was 11.49 cm (95 %CI 10.90 to 12.08).
Conclusions Our analysis showed that new adopters of POEM with previous advanced endoscopy experience required about 25 procedures to attain proficiency. The average time for each procedure once proficiency was attained was about 85 minutes.
Assessment of Alzheimer's Disease Imaging Biomarkers in World Trade Center Responders with Cognitive Impairment at Midlife
Authors: Kritikos Minos , Franceschi Ana M. , Vaska Paul , Clouston Sean A. P. , Huang Chuan , Salerno Michael , Deri Yael , Tang Cheuk , Pellecchia Alison , Santiago-Michels Stephanie , Sano Mary , Bromet Evelyn J. , Lucchini Roberto G. , Gandy Sam , Luft Benjamin J. 
Published: September 2022

Abstract
Purpose Incidence of early onset neurocognitive dysfunction has been reported in World Trade Center (WTC) responders. Ongoing studies are investigating the underlying etiology, as we are concerned that an underlying risk of neurodegenerative dementia may be occurring because of their stressful and neurotoxic exposures to particulate matter when they responded to the search and rescue efforts on September 11, 2001. The purpose of this study is to report preliminary results from two ongoing positron emission tomography (PET)/magnetic resonance imaging (MRI) imaging studies investigating the presence of Alzheimer's disease (AD) biomarkers, such as β-amyloid, tau, and neurodegeneration, and compare our findings to published norms.
Methods We present findings on 12 WTC responders diagnosed with either cognitive impairment (CI) or mild cognitive impairment (MCI), now at midlife, who underwent PET/MRI brain imaging as part of ongoing studies. Six responders with CI received [18F] florbetaben (FBB) to detect β-amyloidosis and six separate responders with MCI received [18F] flortaucipir (FTP) to detect tauopathy. All 12 responders underwent concomitant MRI scans for gray matter volume analysis of neurodegeneration.
Results PET analysis revealed 50% FBB and 50% of FTP scans were clinically read as positive and that 50% of FTP scans identified as consistent with Braak's stage I or II. Furthermore, one responder identified as centiloid positive for AD. Gray matter volumes from MRI analyses were compared with age/sex-matched norms (Neuroquant), identifying abnormally low cortical volumes in the occipital and temporal lobes, as well as the inferior temporal gyri and the entorhinal cortex.
Conclusion These preliminary results suggest that WTC responders with neurocognitive dysfunction may be at increased risk for a neurodegenerative dementia process as a result of their exposures at September 11, 2001.
Onset of Mucormycosis in Patients with COVID-19: A Systematic Review on Patients' Characteristics
Authors: Ghasemi Shohreh , Dashti Mahmood , Fahimipour Amir , Daryakenari Ghazaleh , Mirzaei Fatemeh , Akbari Fatemeh , Khurshid Zohaib 
Published: September 2022

AbstractMucormycosis has a significant impact on patients' standard of living and, therefore, a high clinical suspicion, prediagnosis, and rapid treatment are critical in easing patients' suffering and fast recovery. Our focus is to conduct an organized review based on various variables on the patients' characteristics having mucormycosis in severe novel coronavirus disease 2019 (COVID-19). We examined Embase, PubMed-Medline, LitCovid, Web of Science, Scopus, and the reference lists of included case reports up to September 20, 2021, using the Medical Subject Heading (MeSH) phrases and other keywords related to this topic. Subsequently, we investigated associated comorbidities, patient characteristics, position of mucormycosis, steroids use, body involvements, and outcomes. Overall, 77 studies were conducted and among these, 72 studies mentioned that the patients' age to be 48.13±14.33 (mean±standard deviation [SD]) years. Diabetes mellitus (DM) was reported in 77.9% (n=60) of cases. Studies showed that central nervous system (CNS) and bone involvement were reported in 62.3 (n=48) and 53.2% (n=41), respectively. More fatalities were observed in patients with mucormycosis with the active form of COVID-19. Also, men infected with mucormycosis significantly affected by COVID-19. In the end, mortality was higher in males with mucormycosis. As a result, a solid investigation into the root cause of mucormycosis, especially in COVID-19, should be included in the study plan. If the patient is COVID-19-positive and immunosuppressed, this opportunistic pathogen diagnostic test should not be overlooked.
Utility of 99mTechnetium Pertechnetate Thyroid Scan and Uptake in Thyrotoxic Patients: Jordanian Experience
Authors: Al-Muqbel Kusai M. 
Published: September 2022

Abstract
Objective The objective of this study was to assess our local experience with 99mTechnitium thyroid uptake (TcTU) in thyrotoxicosis by examining mean and range of TcTU in both euthyroid patients and thyrotoxic patients. We also wanted to see how well TcTU performed as a substitute for radioiodine thyroid uptake in thyrotoxicosis.
Methods The medical records of thyrotoxic patients were reviewed retrospectively. Inclusion criteria were: (1) thyrotoxicosis was proven biochemically, (2) the patient underwent TcTU at the time of thyrotoxicosis diagnosis, (3) at least 6 months of follow-up, and (4) the final diagnosis was documented. All TcTU of euthyroid patients were also reviewed to determine local normal TcTU mean and range. Patients were divided into three groups: Graves' disease, toxic nodular goiter, and subacute thyroiditis. Each patient group's TcTU mean and range were assessed separately.
Results There were 209 patients in total (54 euthyroid, 112 Graves' disease, 26 toxic nodules, and 17 patients with subacute thyroiditis). TcTU mean±standard deviation and range for euthyroid patients were 1.5±1.1% and 0.17 to 4.8%, 10.6±10% and 0.43 to 40% for Graves' disease, 4.5±4% and 0.6 to 15% for toxic nodules, and 0.5±0.4% and 0.18 to 1% for subacute thyroiditis. Although one-third of thyrotoxic patients' TcTU values overlapped with the normal TcTU range, the diagnosis was made using qualitative image analysis. Subacute thyroiditis was characterized by poor thyroid visualization, whereas Graves'/toxic nodular goiter was well visualized.
Conclusion The mean and range of our local normal TcTU were similar to those previously published. TcTU was a useful alternative to radioiodine in the evaluation of thyrotoxicosis. About two-thirds of the patients had accurate test results. The diagnosis was reached in the remaining one-third of patients by combining quantitative and qualitative image features. This method allowed us to stop giving radioiodine to our patients, resulting in a significant reduction in patient radiation exposure.
External Quality Assessment Data for Investigation of von Willebrand Disease: Focus on Relative Utility of Contemporary Functional von Willebrand Factor Assays. The United Kingdom National External Quality Assessment Scheme (UK NEQAS) Experience
Authors: Jennings Ian , Reilly-Stitt Chris , Lowe Anna , Kitchen Steve , Walker Isobel 
Published: September 2022

AbstractVon Willebrand disease (VWD) is one of the most common hereditary bleeding disorders. Effective management of patients and their families depends on accurate diagnosis and subtype classification, and quality assurance including participation in proficiency testing programs is essential to ensure the accuracy of the panel of assays required to achieve this diagnosis. We report here findings from recent external quality assessment (EQA) exercises, as well as from a questionnaire about diagnostic practices employed by centers in the United Kingdom National Quality Assessment Scheme (UK NEQAS) performing von Willebrand factor (VWF) assays. Plasma samples from donors with VWD, “normal” donors, the International Society for Thrombosis and Haemostasis Scientific Subcommittee (ISTH SSC) plasma standard, and whole blood samples were sent to participants in the UK NEQAS BC program for VWF investigation. Calibration of lot#5 of the ISTH SSC plasma standard was shown to give improved comparability between the recovered value from an EQA exercise and the assigned potency for VWF activity assays. Diagnostic accuracy and precision amongst UK NEQAS participants was good, with an average 99% of centers reporting the correct interpretation for normal, type 1 and type 2 VWD samples, 100% diagnostic accuracy for centers performing FVIII binding assays, and good agreement amongst centers performing multimeric analysis. Genetic analysis of the VWF gene by specialist centers demonstrated errors in the genotyping process in one center, but also demonstrated failings in the interpretation of results in other centers. Despite evidence of good laboratory accuracy and precision in their assays, a questionnaire identified marked variation in diagnostic criteria employed, underlining the importance of guidelines to support the diagnosis of VWD.
Effect of Poly-L-Lactic Acid Mesh Augmentation on Cyclic Gap Formation in Transosseous Patellar Tendon Repair: A Biomechanical Study
Authors: Gould Heath P. , Rate William R. , Harrell Ryan A. , Abbasi Pooyan , Fillar Allison L. 
Published: September 2022

AbstractNo previous study has investigated poly-L-lactic acid (PLLA) surgical mesh augmentation in the repair of inferior pole patellar tendon rupture. We compared the biomechanical properties of transosseous patellar tendon repair with PLLA surgical mesh augmentation to transosseous repair without augmentation. Ten matched pairs of cadaveric knees were used. Specimens in each pair were randomized to undergo the transosseous technique alone or the transosseous technique augmented with a PLLA surgical mesh. An inferior pole patellar tendon rupture was simulated and the repair procedure was performed. Specimens were cyclically loaded for 500 cycles. Gap formation was measured using two sensors placed medial and lateral to the repair site. After cyclic loading, load to failure was determined by pulling the tendon at a constant rate until a sudden decrease in load occurred. The primary outcome measure was cyclic gap formation at the medial and lateral sensors. Compared with controls, specimens that underwent PLLA mesh-augmented repair had significantly lower medial gap formation at all testing intervals up to 500 cycles (p < 0.05) and significantly lower lateral gap formation at all testing intervals from 10 to 500 cycles (p < 0.05). Transosseous patellar tendon repair augmented with a PLLA woven mesh device provided significantly greater resistance to gap formation compared with transosseous repair alone. These results suggest that PLLA mesh augmentation of the transosseous technique is biomechanically effective for patellar tendon repair.
Patient Perceptions of Wearable and Smartphone Technologies for Remote Outcome Monitoring in Total Knee Arthroplasties
Authors: Kurtz Steven M. , Higgs Genymphas B. , Chen Zhongming , Koshut William J. , Tarazi John M. , Sherman Alain E. , McLean Scott G. , Mont Michael A. 
Published: September 2022

AbstractWhile there is enthusiasm for wearables and smartphone technologies in evaluating clinical outcomes among clinicians, less is known about the willingness of patients who have osteoarthritis (OA) to consent for remote outcome monitoring. We developed an Institutional Review Board-approved questionnaire to assess patient perceptions of remote monitoring technologies in a high-volume orthopaedic clinical center. Fifty total knee arthroplasty (TKA) patients (56% female; mean age: 61 years, range: 23–89) and fifty nonoperative OA knee patients (54% female; mean age: 58 years, range: 25–89) routinely consulted in the clinic as part of their OA treatment and consented to participate in the study. Patient perceptions were compared using Pearson's chi-square analyses with a significance threshold of p < 0.05. We found that TKA patients were more receptive to the use of smartphone apps (84 vs. 60%, p = 0.008) and wearable sensors (80 vs. 48%, p < 0.001) and learning to use custom wearables (72 vs. 38%, p = 0.002) than nonoperative OA knee patients as part of their treatment. Likewise, the majority of TKA patients were willing to use the global positioning system in their postoperative technology (54 vs. 18%, p < 0.001), especially if they were only active during certain circumstances (62 vs. 24%, p < 0.001). TKA patients also expressed willingness to have their body movement (68%), balance (70%), sleep (76%), and cardiac output (80%) tracked using remote technologies. Overall, we found that TKA patients were highly receptive to using wearable technology in their treatments, whereas nonoperative OA knee patients were generally unreceptive. Our study challenges the concept that current wearable technology approaches will be generally effective as a tool to remotely monitor all patients across the OA severity landscape.
The Relationship between Sphenoid Sinus, Carotid Canal, and Optical Canal in Paranasal Sinus Computed Tomography in Children
Authors: Tursun Serkan , Bayar Muluk Nuray , Inal Mikail , Göncüoğlu Alper , Şencan Ziya 
Published: September 2022

Abstract
Objectives The authors examined the structural differences in the paranasal sinus region at sphenoid sinus in the pediatric population.
Methods Paranasal sinus computed tomography (PNSCT) images of 86 pediatric subjects (30 males, 56 females) were included. In 13 to 15 years of age group (n=34) and ≥16 years of age group (n=52), sphenoid sinus pneumatization (SSP), optic canal and carotid canal classifications and dehiscence evaluation were performed.
Results In both sexes, type 1 and type 2 SS pneumatization were observed more frequently on both the right and left sides. On the right side, type 2> type 1; on the left side type 1> type 2 optic canals were detected in both gender. Type 3 optic canals were detected in 8.8 to 14.7% of the 13 to 15 years of age group; and 11.5 to 17.3% of ≥16 years of age group. Type 4 optic canals were detected in 2.9% of the 13 to 15 years of age group and 1.9% of the ≥16 years of age group bilaterally. Optic canal dehiscence was detected in 26.5% of the 13 to 15 years of age group and 17.3% of the ≥16 years of age group. Type 1 and type 2 carotid canals are most common in children, the percentages for type 3 carotid canals were 1.8 to 3.6% in children.
Conclusion In pneumatized SS, optic canal classifications got increased values which showed protrusion into the sphenoid sinus wall. Therefore, in children, the surgeons must be very careful for optic canal being nearer to the sphenoid sinus walls.
Advances in Percutaneous Management of Pulmonary Embolism
Authors: Kerrigan Jimmy , Morse Michael , Haddad Elias , Willers Elisabeth , Ramaiah Chand 
Published: September 2022

AbstractAcute pulmonary embolism (PE) is a leading cause of morbidity and mortality worldwide. Systemic anticoagulation remains the recommended treatment for low-risk PE. Systemic thrombolysis is the recommended treatment for PE with hemodynamic compromise (massive/high-risk PE). A significant number of patients are not candidates for systemic thrombolysis due to the bleeding risk associated with thrombolytics. Historically, surgical pulmonary embolectomy (SPE) was recommended for massive PE with hemodynamic compromise for these patients. In the last decade, catheter-directed thrombolysis (CDT) has largely replaced SPE in the patient population with intermediate risk PE (submassive), defined as right heart strain (as evidenced by right ventricle enlargement on echocardiogram and/or computed tomography, usually along with elevation of troponin or B-type natriuretic peptide). Use of CDT increased in the last few years due to high incidence of PE in hospitalized patients with coronavirus disease 2019 pneumonia, and the use of mechanical thrombectomy (initially reserved for those with contraindications to thrombolysis) has also grown. In this article, we discuss the value of the PE response team, our approach to management of submassive (intermediate risk) and massive (high risk) PE with systemic thrombolytics, CDT, mechanical thrombectomy, and surgical embolectomy.