Diagnosis, Therapy and Follow-up of Cervical Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry No. 032/033OL, May 2021) – Part 2 with Recommendations
on Psycho-oncology, Rehabilitation, Follow-up, Recurrence, Palliative Therapy and Healthcare Facilities
Authors: Fehm Tanja , Stübs Frederik A. , Koch Martin C. , Mallmann Peter , Dannecker Christian , Dietl Anna , Sevnina Anna , Mergel Franziska , Lotz Laura , Ehret Anne , Gantert Daniel , Martignoni Franca , Cieslik Jan-Philipp , Menke Jan , Ortmann Olaf , Stromberger Carmen , Oechsle Karin , Hornemann Beate , Mumm Friederike , Grimm Christoph , Sturdza Alina , Wight Edward , Loessl Kristina , Golatta Michael , Hagen Volker , Dauelsberg Timm , Diel Ingo , Münstedt Karsten , Merz Eberhard , Vordermark Dirk , Lindel Katja , Wittekind Christian , Küppers Volkmar , Lellé Ralph , Neis Klaus , Griesser Henrik , Pöschel Birgit , Steiner Manfred , Freitag Ulrich , Gilster Tobias , Schmittel Alexander , Friedrich Michael , Haase Heidemarie , Gebhardt Marion , Kiesel Ludwig , Reinhardt Michael , Kreißl Michael , Kloke Marianne , Horn Lars-Christian , Wiedemann Regina , Marnitz Simone , Letsch Anne , Zraik Isabella , Mangold Bernhard , Möckel Jochen , Alt Céline , Wimberger Pauline , Hillemanns Peter , Paradies Kerstin , Mustea Alexander , Denschlag Dominik , Henscher Ulla , Tholen Reina , Wesselmann Simone , Beckmann Matthias W. ,   Carolin C.Hack
Published: February 2022

Abstract
Aim This is an update of the interdisciplinary S3-guideline on the Diagnosis, Therapy and Follow-up of Cervical Cancer (AWMF Registry No. 032/033OL), published in March 2021. The
work on the updated guideline was funded by German Cancer Aid (Deutsche Krebshilfe) as part of the German Guideline Program in Oncology. The guideline was coordinated by the German
Society of Gynecology and Obstetrics (Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, DGGG) and the Working Group on Gynecological Oncology (Arbeitsgemeinschaft
Gynäkologische Onkologie, AGO) of the German Cancer Society (Deutsche Krebsgesellschaft, DKG).
Method The process used to update the 2014 S3-guideline was based on an appraisal of the available evidence using the criteria of evidence-based medicine, adaptations of existing
evidence-based national and international guidelines or – if evidence was lacking – on the consensus of the specialists involved in compiling the update. After an initial review of the
current literature was carried out according to a prescribed algorithm, several areas were identified which, in contrast to the predecessor version from September 2014, required new
recommendations or statements which would take account of more recently published literature and the recent appraisal of new evidence.
Recommendations The short version of this guideline consists of recommendations and statements on palliative therapy and follow-up of patients with cervical cancer. The most
important aspects included in this updated guideline are the new FIGO classification published in 2018, the radical open surgery approach used to treat cervical cancer up to FIGO stage IB1,
and the use of the sentinel lymph node technique for tumors ≤ 2 cm. Other changes include the use of PET-CT, new options in radiotherapy (e.g., intensity-modulated radiotherapy, image-guided
adaptive brachytherapy), and drug therapies to treat recurrence or metastasis.