bluuebunny/crossref_metadata_2025_split huggingface dataset:
PTH Spikes During Surgical Treatment for Secondary and Tertiary Hyperparathyroidism: A Prospective Observational Study
Authors: Silveira Andre Albuquerque , Brescia Marilia D'Elboux Guimaraes , do Nascimento Climerio Pereira , Magnabosco Felipe Ferraz , Arap Sergio Samir , de Menezes Montenegro Fabio Luiz 
Published: March 2022

AbstractBackgroundThe aim of the present study was to determine whether PTH spikes in renal hyperparathyroidism can interfere with the interpretation of intraoperative PTH monitoring and to determine its frequency and characteristics.MethodsThis was a prospective observational study of consecutive patients who underwent surgical treatment in a single tertiary institution. Patients were divided into two groups: spike and no spike. Patients with secondary and tertiary hyperparathyroidism were analyzed separately. Intraoperative PTH monitoring by venous serial samples: two samples were taken before the excision of the parathyroid gland, and two others were taken after resection.ResultsPTH spikes occurred in 23.5% (53 of 226), and their occurrence was similar between secondary and tertiary hyperparathyroidism patients (p = 0.074). The relative PTH spike intensity was higher in transplanted patients than in dialysis patients (55 vs. 20%, p = 0.029). A characteristic of the secondary hyperparathyroidism patients was the highest frequency of surgical failure (23 vs. 7.5%, p = 0.016) and the higher occurrence of supernumerary glands in the spike group (23 vs. 10.3%, p = 0.035). Supernumerary parathyroid was associated with surgical failure [19.1 (6.5–55.7) odds ratio [confidence interval], p < 0.001). In the studies evaluating the diagnostic test validity for patients on dialysis and experiencing spikes, the most significant impacts were in the sensitivity, accuracy, and negative predictive value of the method.ConclusionsPTH spikes occurred in up to 23.5% of renal hyperparathyroidism surgical treatments and can negatively influence the intraoperative parathyroid hormone monitoring. Regarding the phenomenon of PTH spikes, it is prudent to think about the possibility of a hyperplastic supernumerary gland.
Synthesis, microstructure and indentation Vickers hardness for (Y3Fe5O12)x/Cu0.5Tl0.5Ba2Ca2Cu3O10-δ composites
Authors: Rekaby M. , Mohammed N. H. , Ahmed M. , Abou-Aly A. I. 
Published: March 2022

AbstractHigh-performance and low-cost composites are engineers’ dream for technological applications. To fulfill the material for an engineering application, it is important to understand the mechanical properties of the material. The primary goal of this research is to investigate the impact of nano-sized Yttrium iron garnet (Y3Fe5O12) addition on the microstructure and mechanical properties of the polycrystalline Cu0.5Tl0.5Ba2Ca2Cu3O10-δ (CuTl-1223) superconductor. Co-precipitation and solid-state reaction methods were utilized to prepare Y3Fe5O12 nanoparticles and Cu0.5Tl0.5Ba2Ca2Cu3O10-δ superconductor, respectively. (Y3Fe5O12)x/Cu0.5Tl0.5Ba2Ca2Cu3O10-δ nanoparticle/superconductor composites were formed by adding small contents of Y3Fe5O12 (x = 0.00, 0.02, 0.04, 0.06, 0.08, and 0.10 wt%) to the CuTl-1223 matrix. The volume fraction percentage of the main phase, CuTl-1223, was increased from 87.9 to 91.4% as x was adjusted from 0.00 to 0.04 wt%. The unit cell parameters (a and c) remained unchanged following the addition of Y3Fe5O12 nanoparticles to the host CuTl-1223. The porosity percentage (P %) was decreased from 39.1 to 29.4% as x was increased from 0.00 to 0.10 wt%. Thus, the addition of Y3Fe5O12 nanoparticles has the ability to reduce weak links and voids among the CuTl-1223 superconducting grains. The grain morphology for the prepared composites was identified through scanning electron microscopy. The different elemental compositions were detected by energy-dispersive X-ray measurements. Vickers microindentation hardness test was employed to study the mechanical strength of the prepared composites. Analysis and modelling of Vickers hardness (Hv) versus test load (F) were done through various models. Meyer’s empirical law showed that all the prepared composites follow normal indentation size effect behaviour. Hays and Kendall model clarified that the applied test load was sufficient to produce both elastic and plastic deformation for the investigated samples. The elastic/plastic deformation model indicated that the prepared samples contain an elastic relaxation portion that recovers after withdrawing the test load. The proportional sample resistance and modified proportional sample resistance models confirmed the HK model findings. Moreover, the HK model was found to be the most suitable model for describing the microhardness results of the prepared samples. Furthermore, the elastic modulus (E), yield strength (Y), fracture toughness (K) and brittleness index (B) for the prepared composites were calculated as function of Y3Fe5O12 addition.
Strategies to incorporate a fluorinated acrylate monomer into polymer particles: from particle morphology to film morphology and anticorrosion properties
Authors: Chimenti S. , Vega J. M. , Paulis M. , Leiza J. R. 
Published: March 2022

AbstractFour strategies to incorporate a fluorinated monomer (perfluoro octyl acrylate, POA) into a waterborne polymeric dispersion are investigated. Due to the very low water solubility of the POA monomer, three of the strategies use miniemulsion droplets containing the whole POA monomer in the initial charge. The rest of the comonomers of the formulation (methyl methacrylate, MMA, and n-butyl acrylate, BA) are partially incorporated in the initial miniemulsion or fed to the reactor as a preemulsion. In the fourth strategy, a conventional seeded semibatch emulsion polymerization is carried out using cyclodextrin in the seed and feeding the POA/MMA/BA preemulsion to the reactor. Each process strategy led to a distinct particle morphology and hence a particular film morphology. We found that the strategy that produced core–shell particles with the core composed by pure polyPOA yielded the films that showed the best corrosion protection as measured in salt-spray test (1200 h standing without damage).
First experiences with PET-MRI/CT in radiotherapy planning for cervical cancer
Authors: Scharl Sophia , Weidenbaecher Clara-Bianca , Hugo Christine , Brambs Christine E. , Knorr Karina , Combs Stephanie E. , Schüttrumpf Lars 
Published: March 2022

Abstract
Purpose
PET-CT has recently been included in the NCCN staging recommendations for cervical cancer stages II–IV and is already routinely applied to radiotherapy planning for other malignancies, as it is expected to provide higher accuracy for the detection of areas with tumor cell spread. In this study, we report on our first experiences of PET-based radiotherapy planning for cervical cancer.

Methods
19 patients with cervical cancer that underwent pre-therapeutic PET imaging treated at our institution between January 2016 and April 2019 were included in the study. Information on the primary tumor, lymph node involvement, metastatic spread and changes in the radiotherapy procedure based on the PET findings are described.

Results
A previously unknown primary tumor extension that was detected by PET imaging in one patient. In patients who underwent a PET before the systematic pelvic and paraaortic lymphonodectomy (n = 2), PET was false negative for pelvic lymph node metastases in 50%. In patients who underwent a PET after the systematic LNE (n = 13), additional lymph node metastases were detected in seven patients (53.80%). Distant metastases were suspected in three patients (15.7%) based on PET imaging. The suspicion was confirmed in one patient (peritoneal spread) and excluded in two patients (supra-diaphragmatic lymph nodes). In 13 patients (68.4%), RT procedures were altered due to findings in PET imaging.

Conclusion
PET-based radiochemotherapy planning may improve control rates by identifying areas of tumor cell spread eligible for dose escalation. False positivity, however, should be excluded in patients with findings that lead to major modifications of the therapeutic strategy.
Defining the limits and indications of the Draf III endoscopic approach to the lateral frontal sinus and maximizing visualization and maneuverability: a cadaveric and radiological study
Authors: Papatsoutsos Efstathios , Kalyvas Aristotelis , Drosos Evangelos , Neromyliotis Eleftherios , Koutsarnakis Christos , Komaitis Spyridon , Chatzinakis Vasileios , Stranjalis George , Georgalas Christos 
Published: March 2022

Abstract
Purpose
The DRAF III procedure has been used for access to the lateralmost part of the frontal sinus. We sought to identify anatomical and radiological measurements as well as modifications that predict the lateral limits of visualization and surgical access after this procedure.

Methods
Seven cadaver heads were imaged with computed tomography scan. The distance from midline to the medial orbital wall (MOWD), midline to the lateral end of the frontal sinus (MLD), the sum of MLDs (SMLD), interorbital distance (IOD) and the shortest anteroposterior distance of the frontal recess (APD) were utilized. The ratios MLD/MOWD, and SMLD/IOD were calculated. The same distances were measured on 41 CT scans. Orbital transposition (OT) and partial resection of the piriform aperture (PAR) were performed; the visualization and reach were assessed. The angle of insertion was measured before and after the modifications.

Results
Only the ratio MLD/MOWD was consistently predictive of access to the lateral, superior and posterior wall of the frontal sinus. Following the modifications, a visualization of 100% laterally was achieved with the 30- and 45 degree endoscopes and every lateral recess could be reached with the 70 degree suction. A mean increase of the angle of insertion of 25.3 and 59.6% was recorded after OT and PAR, respectively.

Conclusions
IOD rather than APD defines the limits of the Draf III approach to the lateral frontal sinus and MLD/MOWD ratio can serve as a useful preoperative tool. Along to the already described OT, PAR increases visualization and reach of the lateral frontal sinus.
Beneficial effects of Silexan on co-occurring depressive symptoms in patients with subthreshold anxiety and anxiety disorders: randomized, placebo-controlled trials revisited
Authors: Bartova Lucie , Dold Markus , Volz Hans-Peter , Seifritz Erich , Möller Hans-Jürgen , Kasper Siegfried 
Published: March 2022

AbstractSilexan is a proprietary active substance produced from Lavandula angustifolia, with proven anxiolytic efficacy in subthreshold and generalized anxiety disorder as well as in mixed anxiety and depressive disorder with beneficial impact on anxiety-related sleep disturbances. The pharmacological profile and clinical observations suggest that Silexan may also have an antidepressant effect. To investigate the effect of Silexan on co-occurring depressive symptoms, we present a meta-analysis of the five placebo-controlled clinical trials hitherto performed with Silexan in subthreshold anxiety (n = 3) and anxiety disorders (n = 2). Patients of all trials received Silexan 1 × 80 mg/day or placebo for 10 weeks according to random assignment. Assessment of the antidepressant effect was based on item ‘depressed mood’ from the Hamilton Anxiety Rating Scale (HAMA) administered in all trials and on the total scores of the Montgomery Åsberg Depression Rating Scale (MADRS) or the Hamilton Depression Rating Scale (HAMD) used in three trials. After 10-week treatment, patients receiving Silexan showed significantly more pronounced score reduction for HAMA item ‘depressed mood’ than those in the placebo group (p = 0.01). Significant superiority of Silexan over placebo could also be shown for mean MADRS or HAMD total score reduction (three studies; p < 0.01). Silexan-treated patients with more severe depressive symptoms at baseline showed more pronounced improvements than those with milder symptoms. Our meta-analysis clearly shows that Silexan has a beneficial effect on co-occurring depressive symptoms in patients with subthreshold anxiety and anxiety disorders and may, hence, lead to important therapeutic implications for depressive disorders.
Telestration with augmented reality for visual presentation of intraoperative target structures in minimally invasive surgery: a randomized controlled study
Authors: Wild C. , Lang F. , Gerhäuser A. S. , Schmidt M. W. , Kowalewski K. F. , Petersen J. , Kenngott H. G. , Müller-Stich B. P. , Nickel F. 
Published: March 2022

Abstract
Aims
In minimally invasive surgery (MIS), intraoperative guidance has been limited to verbal communication without direct visual guidance. Communication issues and mistaken instructions in training procedures can hinder correct identification of anatomical structures on the MIS screen. The iSurgeon system was developed to provide visual guidance in the operating room by telestration with augmented reality (AR).

Methods
Laparoscopic novices (n = 60) were randomized in two groups in a cross-over design: group 1 trained only with verbal guidance first and then with additional telestration with AR on the operative screen and vice versa for group 2. Training consisted of laparoscopic basic training and subsequently a specifically designed training course, including a porcine laparoscopic cholecystectomy (LC). Outcome included time needed for training, performance with Global Operative Assessment of Laparoscopic Skills (GOALS), and Objective Structured Assessment of Technical Skills (OSATS) score for LC, complications, and subjective workload (NASA-TLX questionnaire).

Results
Telestration with AR led to significantly faster total training time (1163 ± 275 vs. 1658 ± 375 s, p < 0.001) and reduced error rates. LC on a porcine liver was performed significantly better (GOALS 21 ± 5 vs. 18 ± 4, p < 0.007 and OSATS 67 ± 11 vs. 61 ± 8, p < 0.015) and with less complications (13.3% vs. 40%, p < 0.020) with AR. Subjective workload and stress were significantly reduced during training with AR (33.6 ± 12.0 vs. 30.6 ± 12.9, p < 0.022).

Conclusion
Telestration with AR improves training success and safety in MIS. The next step will be the clinical application of telestration with AR and the development of a mobile version for remote guidance.
Der Linear-Planetenmotor
Authors: Nikowitz Mario , Brunner Andreas , Schrödl Manfred 
Published: March 2022

ZusammenfassungDie vorliegende Abhandlung stellt einen neuartigen Ansatz eines Linearmotors basierend auf dem Planetenmotorprinzip vor. Bei dem so genannten Planetenmotor handelt es sich um eine Multi-Rotor-Permanentmagnet-Synchronmaschine (PMSM), welche erstmals im Jahr 2017 veröffentlicht wurde. Durch das elektromagnetische Design des Motors in Kombination mit der geschickten Verschaltung der einzelnen Wicklungen verhält sich der Planetenmotor wie eine herkömmliche dreiphasige PMSM und kann so mit handelsüblichen Umrichtern feldorientiert betrieben werden. Um nun eine lineare Bewegung zu ermöglichen, ist eine Modifikation des Wicklungssystems notwendig. Durch den speziellen Aufbau des Planetenmotors ist es außerdem möglich, eine kostengünstige Lagerung des Linearschlittens zu entwickeln, welche den Einsatz von zusätzlichen externen Lagern überflüssig macht. Messungen am Prototyp bestätigen die Performance des neuartigen Linear-Planetenmotors.
Usefulness of the trabecular bone score in maintenance dialysis patients
Authors: Malle Oliver , Bergthaler Markus , Krisper Peter , Amrein Karin , Dimai Hans Peter , Kirsch Alexander H. , Rosenkranz Alexander R. , Pieber Thomas , Obermayer-Pietsch Barbara , Fahrleitner-Pammer Astrid 
Published: March 2022

Summary
Background
The number of dialysis patients is steadily increasing. Associated comorbidities include impaired bone and mineral metabolism, termed chronic kidney disease-mineral and bone disorder (CKD-MBD), leading to a high fracture risk, increased morbidity and mortality and impaired quality of life. While the bone density is assessed with dual-energy X‑ray absorptiometry (DXA), the trabecular bone score (TBS) captures the image texture as a potential index of skeletal microarchitecture. The aim of this study was to evaluate the clinical relevance of DXA and TBS in dialysis patients with and without prevalent fractures.

Methods
Bone disorders were evaluated in 82 dialysis patients (37% female) at the University Hospital of Graz, Austria, by DXA including the assessment of the TBS based on a patient interview and the local routine patient database software. The patient cohort was stratified by having sustained a fragility fracture in the past or not. Descriptive statistics, t‑tests for continuous variables and χ2-tests for nominal variables including results of DXA and TBS were performed to compare these groups considering the dialysis modality and duration as well as the number of kidney transplantations.

Results
Of the 82 patients, 32 (39%) had a positive history of fractures. There was a significant association between dialysis duration and fracture prevalence (p < 0.05) as well as musculoskeletal pain (p < 0.01). No significant correlation between DXA/TBS parameters and musculoskeletal pain could be established. The DXA scores did not correlate with fracture prevalence with the exception of DXA radius measurements; however, fracture prevalence significantly correlated inversely with TBS (p < 0.001).

Conclusion
The use of DXA has a limited role in fracture prediction in dialysis patients; however, the TBS seems to add information as an additional tool for fracture risk estimation in this patient population.
Effect of CO2 Phase on Pore Geometry of Saline Reservoir Rock
Authors: Peter Ameh , Jin Xiaoqiang , Fan Xianfeng , Eshiet Kenneth Imo-Imo , Sheng Yong , Yang Dongmin 
Published: March 2022

AbstractThe phase of CO2 present in a saline reservoir influences the change of the pore geometry properties of reservoir rocks and consequently the transport and storage integrity of the reservoir. In this study, digital rock physics was used to evaluate pore geometry properties of rocks saturated with the different phaseCO2-brine under reservoir conditions. The changes in the pore geometry properties due to the different phaseCO2-brine-rock interaction were quantified. In addition to compression, CO2-brine-rock interaction caused a further reduction in porosity by precipitation. Compared to the dry sample, the porosity of the gaseous CO2-br sample was reduced the most, and was lower by 15% after saturation and compression. There was reduction in the pre-compression porosity after compression for all the samples, however, the reduction was highest in the gaseous CO2-br-saturated sample (13%). The flatness of pore surfaces was reduced, and pores became less rounded after compression, especially in supercritical CO2-br-saturated rock. The results from this research provide a valuable input to guide a robust simulation of CO2 storage in reservoir rocks where different phases of CO2 could be present.
Sixteen ways to adapt: a comparison of state-level climate change adaptation strategies in the federal states of Germany
Authors: King Julie P. 
Published: March 2022

AbstractClimate change adaptation (CCA) to reduce or prevent negative climate change impacts and, in some cases, maximize potential benefits is a complex challenge demanding multi-level policy action. In federalist systems, sub-national governments are among key actors for enabling adaptation and their clear commitments can increase collaboration and innovation at the local level. Germany serves as a particularly insightful case for observing the variance among sub-national approaches due to its role as a “leader” in CCA at the national level. This paper provides the first systematic assessment of all sixteen state adaptation strategies in Germany and examines how German states are fostering adaptation, the extent to which their approaches vary, and which patterns have emerged. Based on a qualitative document analysis of over 30 documents, this assessment focuses on five indicators synthesized from literature climate policy analyses and on barriers and facilitating factors of adaptation. Results find that German state strategies are often non-committal sets of recommendations and identify three clusters displaying different degrees of institutionalization and guidance. While federalism allows for flexibility among state responses, the absence of federal mandates and policy standards allows some states to fall behind while others continue to develop their strategies to foster adaptation. These sixteen diverse approaches each have implications for adaptation governance at other levels.
Persisting in Physics and the Physics Olympiad — Impact of Gender Identification and Sense of Belonging on Expectancy-Value Outcomes
Authors: Ladewig Antonia , Köller Olaf , Neumann Knut 
Published: March 2022

AbstractThe German Physics Olympiad is an extracurricular science contest for students. Here, they have the opportunity to compete against other talented students, can do physics outside of school, and take a first step to more engagement in the domain. Yet, female students participate in the competition in fewer numbers and are disproportionally more likely to drop out of the contest earlier than the male students.The present study hence explored the question to which extent the German Physics Olympiad provides a threatening environment for female contestants’ intentions of persisting in physics. A total of 298 participants (28% female) were surveyed with respect to stereotype and social identity threat, as well as gender identification and sense of belonging as predictors of success expectations for and value of choosing to study physics. Success expectations and value of choosing to study physics were used as a measure for career intentions within the expectancy-value model.The results support the conclusion that the contest presents an equally supporting environment for female and male participants. We found no gender differences in success expectations for and value of studying physics. Sense of belonging and gender identification significantly predicted success expectations but not value of choosing to study physics. Female participants in the German Physics Olympiad were also neither affected by stereotype threat nor by social identity threat in their sense of belonging or gender identification.
Role of liver biopsy in management of liver diseases without hepatic nodules following end of the interferon era: experience of a tertiary referral center
Authors: Ehsan Nermine A. , Elsabaawy Maha M. , Sweed Dina M. , Karman Esraa A. , Abdelsameea Eman , Mohamed Anwar A. 
Published: March 2022

AbstractLiver biopsy (LB) is the cornerstone in the management of patients with liver diseases. However, a lot of queries had emerged about its role following the end of the interferon era. The aim of this study was to re-evaluate the current role of LB in the diagnosis of liver diseases. All patients who had underwent LB at the Department of Hepatology, National Liver Institute, from January 2015 through December 2018 were recruited. Indications for LB, pathology reports and medical records of all cases were retrieved, reviewed and statistically analyzed. A total of 275 liver biopsies were collected, 191 males and 84 females with mean age 41.22 ± 13.36 years. Etiological diagnosis made by histopathological evaluation was 48 drug-induced liver injury (DILI), 42 nonalcoholic fatty liver disease (NAFLD), 34 chronic hepatitis B, or C with cholestasis, 29 autoimmune hepatitis, 34 primary sclerosing cholangitis, 13 primary biliary cholangitis, 7 autoimmune overlap syndrome, 13 active bilharziasis and 10 Wilson’s disease. Minor number of cases was diagnosed by different other etiologies. Initial diagnosis was made by liver biopsy and confirmed by clinical response and laboratory findings. Liver biopsy is still considered as the gold standard diagnostic measure of different liver diseases representing an integral component of management decisions in hepatology.