bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Mechanism of Long Non-coding RNA in Cancer Radioresistance/Radiosensitivity: A Systematic Review
Authors: Wu Wenhan , Zhang Shijian , He Jia 
Published: May 2022

Background and purpose: Radioresistance remains a significant challenge in tumor therapy. This systematic review aims to demonstrate the role of long non-coding RNA (lncRNA) in cancer radioresistance/radiosensitivity.Material and methods: The electronic databases Pubmed, Embase, and Google Scholar were searched from January 2000 to December 2021 to identify studies addressing the mechanisms of lncRNAs in tumor radioresistance/sensitivity, each of which required both in vivo and in vitro experiments.Results: Among the 87 studies identified, lncRNAs were implicated in tumor radioresistance/sensitivity mainly in three paradigms. 1) lncRNAs act on microRNA (miRNA) by means of a sponge, and their downstream signals include some specific molecular biological processes (DNA repair and chromosome stabilization, mRNA or protein stabilization, cell cycle and proliferation, apoptosis-related pathways, autophagy-related pathways, epithelial-mesenchymal transition (EMT), cellular energy metabolism) and some signaling mediators (transcription factors, kinases, some important signal transduction pathways) that regulate various biological processes. 2) lncRNAs directly interact with proteins, affecting the cell cycle and autophagy to contribute to tumor radioresistance. 3) lncRNAs act like transcription factors to initiate downstream signaling pathways and participate in tumor radioresistance.Conclusion: lncRNAs are important regulators involved in tumor radioresistance\sensitivity. Different lncRNAs may participate in the radioresistance with the same regulatory paradigm, and the same lncRNAs may also participate in the radioresistance in different ways. Future research should focus more on comprehensively characterizing the mechanisms of lncRNAs in tumor radioresistance to help us identify corresponding novel biomarkers and develop new lncRNA-based methods to improve radioresistance.
Effects of Gastric Acid Secretion Inhibitors for Ventilator-Associated Pneumonia
Authors: Li Fang , Liu Hui , Zhang Luming , Huang Xiaxuan , Liu Yu , Li Boen , Xu Chao , Lyu Jun , Yin Haiyan 
Published: May 2022

Objective: This study analyzed the association of gastric acid secretion inhibitors (GASIs) [including proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs)] with the occurrence of ventilator-associated pneumonia (VAP) and in-hospital mortality in patients who received invasive mechanical ventilation (IMV).Method: Patients who received IMV and used GASI were included based on records in the MIMIC-IV database. The relationships of GASIs with VAP and the in-hospital mortality were determined using univariate and multivariate logistic regression analyses. Also, the effects of GASIs in some subgroups of the population were further analyzed.Results: A total of 18,669 patients were enrolled, including 9191 patients on H2RAs only, 6921 patients on PPIs only, and 2557 were on a combination of the two drugs. Applying logistic regression to the univariate and multivariate models revealed that compared with H2RAs, PPIs had no significant effect on the incidence of VAP, and the combination of H2RAs and PPIs was a risk factor for VAP. Compared with H2RAs, univariate logistic regression revealed that, PPIs and combine the two drugs were both risk factors for in-hospital mortality, but multivariate logistic regression showed that they were not significantly associated with in-hospital mortality. In subgroup analysis, there were interaction in different subgroups of age, PCO2, myocardial infarct, congestive heart failure (P for interaction&lt;0.05).Conclusion: Compared with H2RAs, PPIs did not have a significant association with either VAP or in-hospital mortality; the combination of H2RAs and PPIs was risk factor for VAP, but did not have a significantly associated with in-hospital mortality.
Protective Effect of Nalbuphine Combined With Dexmedetomidine on the Lungs of Children With Atelectasis and Foreign Body in the Bronchus During the Perioperative Period
Authors: Wang Yuan , Han Hong-Yang , Jia Ying-Ping , Zhao Li-Yuan , Li Ying , Zuo Bian-Jing , Zhang Jie 
Published: May 2022

Objective: The present study aims to explore the protective effect of nalbuphine combined with dexmedetomidine on the lungs of children with atelectasis who have a foreign body in a bronchus during the perioperative period.Methods: A total of 180 patients whose computed tomography scan showed atelectasis and a foreign body in a bronchus were randomly divided into three groups: group C (conventional anesthesia group), group D (dexmedetomidine group), and group N + D (nalbuphine combined with the dexmedetomidine group). The following indicators were recorded: 1) heart rate (HR) and mean arterial pressure (MAP) prior to induction (T0), at bronchoscope placement (T1), at intubation after surgery (T2), at tube removal (T3), 10 min after tube removal (T4), 20 min after tube removal (T5), and at awaking (T6); 2) monocyte toll-like receptors (TLRs) TLR⁃2, TLR⁃4, tumor necrosis factor α, interleukin 6, oxygenation index, and the B-line sum at T0, T3, 2 h (T7), and 24 h (T8) after tube removal; and 3) hospital stay after surgery.Results: Compared with group C, in group D and group N + D, 1) the HR and MAP at T1∼T6 were lower; 2) the inflammatory factor indicator and B-line sum were lower, and the oxygenation index was higher at T7 and T8; 3) the agitation and cough scores were decreased during tube removal; and 4) the Ramsay sedation score was higher, and ventilator weaning time was shortened at T4∼T6 (p &lt; 0.05). Compared with group D, in group N + D, 1) the inflammatory factor indicator and B-line sum were lower at T8; 2) the oxygenation index was higher (p &lt; 0.05). Compared with groups C and D, in group N + D, the length of hospital stay was decreased (p &lt; 0.05).Conclusion: In patients with atelectasis and a foreign body in a bronchus during the perioperative period, nalbuphine combined with dexmedetomidine may be capable of reducing the oxidative stress response, improving the oxygenation index, decreasing the pulmonary fluid content, protecting the lung, and facilitating postoperative recovery.
Obesity Induces Disruption of Microvascular Endothelial Circadian Rhythm
Authors: Padgett Caleb A. , Butcher Joshua T. , Haigh Steven B. , Speese Andrew C. , Corley Zachary L. , Rosewater Cody L. , Sellers Hunter G. , Larion Sebastian , Mintz James D. , Fulton David J. R. , Stepp David W. 
Published: May 2022

Obese individuals are at significantly elevated risk of developing cardiovascular disease (CVD). Additionally, obesity has been associated with disrupted circadian rhythm, manifesting in abnormal sleeping and feeding patterns. To date, the mechanisms linking obesity, circadian disruption, and CVD are incompletely understood, and insight into novel mechanistic pathways is desperately needed to improve therapeutic potential and decrease morbidity and mortality. The objective of this study was to investigate the roles of metabolic and circadian disruptions in obesity and assess their contributions in promoting vascular disease. Lean (db/+) and obese (db/db) mice were subjected to 12 weeks of constant darkness to differentiate diurnal and circadian rhythms, and were assessed for changes in metabolism, gene expression, and vascular function. Expression of endothelial nitric oxide synthase (eNOS), an essential enzyme for vascular health, was blunted in obesity and correlated with the oscillatory loss of the novel regulator cezanne (OTUD7B). Lean mice subjected to constant darkness displayed marked reduction in vasodilatory capacity, while endothelial dysfunction of obese mice was not further compounded by diurnal insult. Endothelial gene expression of essential circadian clock components was altered in obesity, but imperfectly phenocopied in lean mice housed in constant darkness, suggesting overlapping but separate mechanisms driving endothelial dysfunction in obesity and circadian disruption. Taken together, these data provide insight into the nature of endothelial circadian rhythm in obesity and suggest a distinct mechanism by which obesity causes a unique circadian defect in the vasculature.
Geomagnetic Response to Rapid Increases in Solar Wind Dynamic Pressure: Event Detection and Large Scale Response
Authors: Madelaire Michael , Laundal Karl M. , Reistad Jone P. , Hatch Spencer M. , Ohma Anders , Haaland Stein 
Published: May 2022

Discontinuities in the solar wind trigger a variety of processes in the magnetosphere-ionosphere system. A rapid increase in solar wind dynamic pressure causes compression of the magnetosphere. This manifests itself as a positive perturbation of the horizontal ground magnetic field at low/mid latitudes. In this study we present a method for detecting these discontinuities in situ solar wind data by using the random forest machine learning algorithm. Each detected event is propagated to Earth and its arrival time is aligned with a corresponding response in the low latitude ground magnetic field. A list of 3,867 events, detected between 1994 and 2019, is presented. We use the list in a superposed epoch analysis of the low/mid latitude response in the ground magnetic field at different local times, and of the high latitude response using the Polar Cap index. A dawn-dusk asymmetry is found at low/mid latitudes with weaker positive perturbations at dawn compared to any other local time sector. This suggests a stronger ring current contribution at dawn assuming the magnetopause contribution to be uniform. During northward IMF the initial response is asymmetric, but returns to symmetry after 30 min. During southward IMF the low/mid latitude response decays rapidly in all local sectors except dawn. After around 30 min the asymmetry has flipped such that the strongest positive perturbation is at dawn. This suggests an amplification of the partial ring current. In addition, a noon-midnight asymmetry is observed during southward IMF with the strongest positive perturbation on the night side suggesting a significant contribution from dipolarization of the geomagnetic field in the near tail. The complex geomagnetic response to rapid increases in solar wind dynamic pressure demonstrates a need for further statistical analyses. Event lists, such as the one presented here, are critical components in such studies.
Póster
Authors: Autores Varios 
Published: May 2022

Durante los días miércoles 25 y jueves 26 de agosto del 2021, se realizó la décimo cuarta versión del Encuentro Departamental de Semilleros de Investigación de la Red Regional de Semilleros de Investigación -RREDSI, Nodo Quindío.
En esta nueva versión, la Universidad del Quindío lideró la organización de este tradicional encuentro departamental, el cual acogió, de manera virtual, a estudiantes de todas las instituciones de educación del Departamento, entre las que se encuentran las universidades Remington, La Gran Colombia Armenia, Alexander Von Humboldt, Corporación Universitaria Unificada Nacional de Educación Superior, Antonio Nariño, Institución Universitaria EAM y el SENA.
Un total de 60 trabajos de investigación socializados en la modalidad de póster, los cuales fueron resultado de la interacción con comunidades y el sector productivo a partir de sus proyectos de semilleros de investigación.
Possibilities of Treatment of Acute Sensorineural Hearing Loss in the New Coronavirus Infection COVID-19
Authors: Саливончик Е.И. , Саливончик Д.П. 
Published: May 2022

В проспективном рандомизированном одноцентровом сплошном сравнительном исследовании оценена эффективность лечения острой нейросенсорной тугоухости винпоцетином (Кавинтоном) при новой коронавирусной инфекции COVID-19. Применение Кавинтона привело к достоверному восстановлению шепотной речи у пациентов с 3,15±1,8 м до 5,23±0,73 м по данным акуметрии, по сравнению с группой пациентов без включения в схему лечения Кавинтона (с 3,16±2,13 м до 3,34±2,35 м), после проведенного курса в течение 1 месяца, р=0,009. Включение Кавинтона в схему лечения в первые 8 дней от острого начала заболевания не имело достоверного преимущества по сравнению с контрольной группой, а после 8-го дня от начала заболевания привело к достоверно лучшему результату – отмечена нормализация шепотной речи в группе 1 (с 2,8±1,57 м до 5,57±0,53 м) по сравнению с группой 2 (с 2,6±2,13 м до 3,2±2,36 м), р=0,018. Использование Кавинтона в лечении острой нейросенсорной тугоухости при новой коронавирусной инфекции COVID-19 оказалось безопасным; он может быть рекомендован в качестве препарата выбора ввиду его патогенетической обоснованности при данном заболевании.
In a prospective randomized single-center continuous comparative study, the effectiveness of the treatment of acute neurosensory hearing loss with vinpocetine (Cavinton) in the new coronavirus infection COVID-19 was evaluated. The use of Cavinton led to a significant recovery of whispered speech in patients from 3.15±1.8 m to 5.23±0.73 m, according to the acumetry, compared with a group of patients without inclusion in the Cavinton treatment regimen (from 3.16±2.13 m to 3.34±2.35 m) after the course for 1 month, p=0.009. The inclusion of Cavinton in the treatment regimen in the first 8 days from the acute onset of the disease did not have a significant advantage compared to the control group, and after 8 days from the onset of the disease led to a significantly better result – normalization of whispered speech was noted in group 1 (from 2.8±1.57 m to 5.57±0.53 m) compared with group 2 (from 2.6±2.13 m to 3.2±2.36 m), p=0.018. The use of Cavinton in the treatment of acute sensorineural hearing loss in the new coronavirus infection COVID-19 turned out to be safe and can be recommended as the drug of choice due to its pathogenetic validity in this disease.
Gambaran Pengetahuan tentang Anemia Gizi Besi pada Remaja Putri di SMP Negeri 1 Polewali Kabupaten Polewali Mandar
Authors: Christin Diana , Sanggelorang Yulianty , Amisi Marsella D 
Published: May 2022

Anemia gizi besi merupakan salah satu dari beberapa masalah gizi di Indonesia yang mana banyak terjadi pada kelompok remaja putri. Remaja putri rentan terhadap masalah anemia gizi besi karena mengalami menstruasi tiap bulannya sehingga kehilangan cadangan zat besi dalam tubuhnya, selain itu perilaku diet yang tidak seimbang yang marak dilakukan oleh remaja putri juga dapat menyebabkan kecukupan zat besi pada remaja putri tidak tercukupi dengan baik (Kemenkes RI, 2018). Data Riskesdas 2018 didapati prevalensi kejadian anemia pada penduduk Indonesia usia 5-14 tahun sebesar 26.8%, dan pada perempuan sebesar 27.2% (Kemenkes RI, 2019). Pengetahuan remaja putri yang rendah akan anemia gizi besi menjadi salah satu faktor penyebab terjadinya anemia gizi besi pada remaja, yang mana pengetahuan berpengaruh terhadap kesadaran seseorang dalam berperilaku Penelitian ini dilakukan pada Juni – Oktober 2021 dengan tujuan mengetahui gambaran pengetahuan anemia gizi besi pada remaja putri di SMP Negeri 1 Polewali. Populasi dalam penelitian sebanyak 338 remaja putri di SMP Negeri 1 Polewali dengan sampel sebanyak 187 orang. Analisis yang digunakan adalah analisis univariat yang mana didapati bahwa pada pertanyaan mengenai definisi anemia gizi besi hampir semua responden telah tahu yaitu dengan persentase sebesar 90.9%, pertanyaan mengenai tanda dan gejala sebesar 88.2% responden telah tahu, begitupula pada pertanyaan mengenai penyebab dan dampak anemia gizi sebagian besar responden telah tahu dimana masing-masing sebesar 87.2% dan 74.9%. Pada kelompok pertanyaan mengenai pencegahan anemia gizi besi, sebagian besar responden telah tahu, namun pada pertanyaan pencegahan mengenai pengelompokan sumber zat besi dari bahan hewani dan nabati sebanyak 51.9% responden tidak tahu.Kata Kunci : Pengetahuan, Anemia Gizi Besi, Remaja Putri
PENERAPAN ANGGARAN RESPONSIF GENDER PADA DINAS PEMBERDAYAAN PEREMPUAN DAN PERLINDUNGAN ANAK DAN DINAS KESEHATAN PROVINSI NUSA TENGGARA TIMUR TAHUN ANGGARAN 2018-2020
Authors: Taneo Amnon Juniarto , Angi Yohana Febiani 
Published: May 2022

Penelitian ini bertujuan untuk mengetahui penerapan anggaran responsif gender pada Dinas pemberdayaan Perempuan dan Perlindungan Anak dan Dinas Kesehatan Provinsi Nusa Tenggara Timur (NTT) tahun 2018-2020. Rumusan masalah dari penelitian ini adalah Bagaimana Penerapan Anggaran Responsif Gender pada Dinas Pemberdayaan Perempuan dan Perlindungan Anak dan Dinas Kesehatan Provinsi NTT tahun 2018-2020?. Penelitian ini termasuk jenis penelitian deskriptif kualitatif dengan menggunakan data sekunder. Objek dari penelitian ini adalah 2 Organisasi Perangkat Daerah (OPD) Provinsi NTT yaitu Dinas Pemberdayaan Perempuan dan Perlindungan Anak dan Dinas Kesehatan. Teknik pengumpulan data dengan dokumentasi, wawancara dan studi kepustakaan. Hasil penelitian ini menunjukan bahwa Dinas Pemberdayaan Perempuan dan Perlindungan Anak telah mangalokasikan anggaran yang responsif gender dengan kategori specific gender dan affirmative action dan Dinas Kesehatan telah mengalokasikan anggaran yang responsif gender dengan kategori spesific gender dan meskipun alokasi anggarannya relatif kecil.
Media Framing in South Korean Drama “Crash Landing on You” towards North Korea
Authors: Sihombing Lambok , Dellavia Saffira 
Published: May 2022

The Korean Wave or well known as Hallyu has become more popular time by times. It shows when the entertainment industry could reach overseas audience and the example is through K-Drama called “Crash Landing on You”. This drama caught the audience attention by the story that they offers and this drama involving the story about South Korea and North Korea that also received several criticism from South Korean and North Korean audience about the story that the drama offers. This journal will discuss about the framing in the drama based on Goffman and Entman perspective and what kind of framing that they implement in this drama.
Keyword: Benefits of Concept Framing, Crash Landing on You, Framing, K-Drama Korean Broadcasting, Natural Framework, North Korea, Primary Framework, Social Framework, South Korea,
The Important Role of Extensive Reading Strategy in Indonesian EFL Learning Contexts
Authors: Wijaya Kristian 
Published: May 2022

Abstract

Academic literacy is one of the paramount global competencies that should be mastered by worldwide university academicians including Indonesian EFL learners. To fully fulfill this holistic educational objectivity, extensive reading plays a key role in fostering overarching Indonesian EFL learners’ target language proficiency due to the inducement of pleasurable, continual, and stress-free L2 reading learning dynamics proffered by this student-centered learning approach. Furthermore, the researcher attempted to delve more profoundly regarding the important role of extensive reading strategy in Indonesian EFL learning contexts. This present qualitative study harnessed a document analysis approach to yield renewable insights for Indonesian EFL experts, practitioners, researchers, and educators concerning the influential impacts potentially promoted by extensive reading strategy implementations. The research results indicated that the inducement of contextual and continual extensive reading activities had successfully improved EFL learners’ L2 reading interest and competencies. Future researchers are advocated to conduct a more exhaustive document analysis on the contrary beliefs and perilous effects generated by extensive reading approach to better impart more appropriate extensive reading programs applicable for Indonesian EFL learners’ reading needs, interests, and levels.

Keywords: document analysis, extensive reading strategy, Indonesian EFL learning contexts
The Important Role of Self-Regulation in Worldwide EFL Learning Contexts
Authors: Wijaya Kristian 
Published: May 2022

Abstract

To better cultivate life-long learning characters within EFL learners, they should be well-trained in activating their utmost self-regulation potentials. By becoming more self-regulated academicians, EFL learners will be more capable of controlling their targeted learning environments, resources, strategies, and time in a better purpose to reach the desired learning outcomes. Concerning this belief, this present qualitative library study was run to exhaustively unearth the crucial role of self-regulation in worldwide EFL learning contexts. To fulfill this main research concern, 30 prior self-regulation studies were conscientiously selected to generate a new enlightenment for globalized ELT educators to nurture their learners’ self-regulation growth in varied language learning situations. The obtained major findings unveiled that a higher degree of self-regulation enabled EFL learners to transform into more life-long knowledge seekers fully reaping more fruitful language learning outcomes. For the betterment of this pivotal psychological investigation, a considerable number of self-regulation literature in line with the interconnected nature of other psychological constructs are highly suggestive for future researchers aiming to conduct identical studies.

Keywords: self-regulation, library study, worldwide EFL learning contexts
Longing for Symbolic Capital in Toni Morrison’s The Bluest Eye: A Bourdieun Estimation
Authors: HOSSAIN MD MOZAFFOR 
Published: May 2022

Toni Morrison’s The Bluest Eye portrays, among other both white and black lives in a less significant mark, the life of a young black girl named Pecola Breedlove whose desperate longing for owning the bluest eyes so as to free herself from the shame and disgrace of her birthed identity has inspired the author to name the novel so. Morrison inserted into the protagonist her (Morrison’s) depraved experience of injustice, inequality, racial discrimination, social stigmatization and, above all, inborn physical outlook, wielded upon the black communities in America during her (Morrison’s) time. While brooding over the question why a black girl would hanker after the bluest eyes, I find the hints, specified descriptions and clarified answers provided by Morrison in the novel logically matched with “Symbolic Capital”, the last of the four capitals delineated by the French philosopher and public intellectual Pierre Bourdieu (1930-2002). Accordingly, this article seeks to appraise Pecola’s yearning for the bluest eyes in Toni Morrison’s The Bluest Eye through Bourdieu’s theory of “Symbolic Capital”.