bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rainfall event‐based surface runoff and erosion in small watersheds under dairy and direct‐seeding grain production
Authors: Ebling Éderson Diniz , Reichert José Miguel , Minella Jean Paolo Gomes , Holthusen Dörthe , Broetto Tiago , Srinivasan Raghavan 
Published: September 2022

AbstractA 3‐year study on erosion and streamflow was conducted in two adjacent paired watersheds that flow into the Passo Real reservoir, one of the largest and most important reservoirs for human water supply and power generation in southern Brazil. The watersheds have similar land use and soil management, but different size and riparian vegetation. The first objective of the study was to monitor and evaluate hydrosedimentological dynamics and effects of riparian vegetation, over a range of rain events, in the two watersheds; the second was to assess the ability of the Limburg Soil Erosion Model (LISEM) to represent these small watersheds in hydrosedimentological terms (runoff and erosion) under individual rain events, in the context of better understanding the role of riparian vegetation and land cover. LISEM is a hydrological model structured on physically based equations that can be used for planning and conservation purposes. Studied rainfall events between 2016 and 2018 had a wide range in total rainfall (10–170 mm), rainfall intensity in 1 h (3–66 mm h−1), stream peak flows (4–5741 L s−1), runoff volume (0.02–40 mm), runoff coefficient (0.1–32%), maximum suspended sediment concentration (20–19 611 mg L−1), and sediment yield (0.002–33.790 Mg km−2). Both watersheds showed a rapid response to rain events with significant runoff generation. Abundance of unpaved roads (often parallel to the slope) promoted high runoff due to channelization effects. South Watershed has 59% more riparian vegetation than North Watershed, but this greater riparian vegetation was not effective in reducing surface runoff and erosion. Furthermore, local adoption of no‐tillage was insufficient to control runoff and sediment yield.
Priority pesticides in Chile: Predicting their environmental distribution, bioaccumulation, and transport potential
Authors: Concha Carolina , Manzano Carlos A. 
Published: September 2022

Abstract
Agriculture is one of the main economic activities in Chile and is associated with extensive use of pesticides, which can represent a risk to the environment and to human health. Currently, there are over 400 pesticides approved for commerce in Chile, including chemicals banned in other countries (e.g., flocoumafen and chlorfenapyr). An empirical analysis of their potential environmental effects is difficult due to this large number, thus opening the doors for the use of computational tools for prioritization efforts based on their persistence, bioaccumulation, and transport potential in the environment. The main objectives of this study were to estimate the properties and environmental distribution of pesticides approved for commerce in Chile and to generate a priority list for further evaluation in local environments. We used the Estimation Program Interface Suite interface to estimate the distribution coefficients, half-lives, and bioaccumulation potential of all pesticides registered in the Chilean Agriculture and Livestock Services. Additionally, the Pov & LRTP Screening Tool was used to estimate their overall persistence and long-range transport potential in the environment. The results were used to develop a P-B-lon range transport (LRT) score, which considered persistence, bioaccumulation, and long-range transport potential. All pesticides were compared to a group of polychlorinated biphenyls (PCBs), used as reference compounds, to generate a list of priority pesticides with persistent organic pollutants characteristics. The results showed that most pesticides were distributed between the organic phase and water, where they also showed the longest half-lives and bioaccumulation potential. A group of 21 pesticides showed relatively high P-B-LRT scores, compared to PCBs, and were classified as priority compounds. The list was further refined based on the volume of sales for each pesticide. Integr Environ Assess Manag 2023;19:676–683. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Inhibiting P2Y12 receptor relieves LPS‐induced inflammation and endothelial dysfunction
Authors: Han Xiuxia 
Published: September 2022

AbstractBackgroundAcute lung injury (ALI) is characterized by abnormal inflammatory response without effective therapies. P2Y12 receptor (P2Y12R) plays a vital role in inflammatory response. This study intends to explore whether P2Y12R antagonists can inhibit LPS‐induced inflammatory injury of human pulmonary microvascular endothelial cells (HPMVECs) and endothelial cell dysfunction.MethodsUsing a cell model of ALI, the role of P2Y12R was investigated in LPS‐induced HPMVECs. The expression of P2Y12R was detected by RT‐qPCR and Western blot analysis assay and TNF‐α, IL‐1β, and IL‐6 levels were analyzed by RT‐qPCR. NO levels were also analyzed through NO kit. The levels of NF‐κB p65, P‐IκB‐α, and IκB‐α, as well as p‐AKT and eNOS levels were detected by Western blot analysis assay. Wound healing assay was performed to evaluate HPMVECs migration. FITC‐dextran was used to evaluate endothelial cell permeability, and the analysis of adherens junction protein VE‐cadherin and endothelial cell tight junction proteins ZO‐1, Claudin 5 and Occludin expression was performed by RT‐qPCR and Western blot analysis assay.ResultsIn vitro, LPS increased the expression levels of P2Y12R and pro‐inflammatory mediators (TNF‐α, IL‐1β, and IL‐6), followed by a decrease in HPMVECs migration. In addition, LPS led to an increase in endothelial cell permeability. P2Y12R antagonists Ticagrelor or clopidogrel treatment significantly reversed these effects of LPS.ConclusionThe inhibitor of P2Y12R was able to decrease inflammatory response, promote migration and improve endothelial cell function and permeability, suggesting a key role of P2Y12R in ALI.
Lifelong Excess in GH Elicits Sexually Dimorphic Effects on Skeletal Morphology and Bone Mechanical Properties
Authors: Dixit Manisha , Louis Leeann D , Basta-Pljakic Jelena , Yildirim Gozde , Poudel Sher-Bahadur , Kumararaja Fancy , List Edward O , Duran Silvana Ortiz , Kopchick John J , Ruff Ryan R , Schaffler Mitchell B , Yakar Shoshana 
Published: September 2022

ABSTRACTExcess in growth hormone (GH) levels, seen in patients with acromegaly, is associated with increases in fractures. This happens despite wider bones and independent of bone mineral density. We used the bovine GH (bGH) transgenic mice, which show constitutive excess in GH and insulin-like growth factor 1 (IGF-1) in serum and tissues, to study how lifelong increases in GH and IGF-1 affect skeletal integrity. Additionally, we crossed the acid labile subunit (ALS) null (ALSKO) to the bGH mice to reduce serum IGF-1 levels. Our findings indicate sexually dimorphic effects of GH on cortical and trabecular bone. Male bGH mice showed enlarged cortical diameters, but with marrow cavity expansion and thin cortices as well as increased vascular porosity that were associated with reductions in diaphyseal strength and stiffness. In contrast, female bGH mice presented with significantly smaller-diameter diaphysis, with greater cortical bone thickness and with a slightly reduced tissue elastic modulus (by microindentation), ultimately resulting in overall stronger, stiffer bones. We found increases in C-terminal telopeptide of type 1 collagen and procollagen type 1 N propeptide in serum, independent of circulating IGF-1 levels, indicating increased bone remodeling with excess GH. Sexual dimorphism in response to excess GH was also observed in the trabecular bone compartment, particularly at the femur distal metaphysis. Female bGH mice preserved their trabecular architecture during aging, whereas trabecular bone volume in male bGH mice significantly reduced and was associated with thinning of the trabeculae. We conclude that pathological excess in GH results in sexually dimorphic changes in bone architecture and gains in bone mass that affect whole-bone mechanical properties, as well as sex-specific differences in bone material properties. © 2022 American Society for Bone and Mineral Research (ASBMR).
Impact of body composition and genotype on haemodynamics during surgery for pheochromocytoma and paraganglioma
Authors: Pang Yingxian , Li Minghao , Jiang Jingjing , Chen Xiang , Fu Yan , Wang Cikui , He Yao , Zhao Yuanzhe , Wang Yong , Guan Xiao , Zhang Liang , Xu Xiaowen , Gan Yu , Liu Yalin , Xie Yaoling , Tang Tingyuan , Wang Jing , Xie Bin , Liang Zhihao , Chen Danlei , Liu Haipeng , Chen Changyong , Eisenhofer Graeme , Liu Longfei , Yi Xiaoping , Chen Bihong T. 
Published: September 2022

AbstractBackgroundMaintaining intraoperative haemodynamic stability can reduce cardiovascular complications during surgery for pheochromocytoma and paraganglioma (PPGL). Risk factors such as tumour size and catecholamine levels are reported to predict haemodynamic responses during surgery for PPGL. We hypothesized that additional factors including body composition and genetic information could further improve prediction.MethodsConsecutive patients with PPGL confirmed by surgical pathology between June 2010 and June 2019 were retrospectively included. Cross‐sectional computed tomography images at the L3 level were used to assess body composition parameters including skeletal muscle area and visceral fat area. Next‐generation sequencing was performed using a panel containing susceptibility genes of PPGL. Differences in clinical‐genetic characteristics and body composition parameters were analysed and compared in patients with and without intraoperative haemodynamic instability (HDI).ResultsWe included 221 patients with PPGL (median age 47 [38–56] years, and 52% male). Among them, 49.8% had Cluster 2 mutations (related to kinase signalling pathways), 44.8% had sarcopenia, and 52.9% experienced intraoperative HDI. Compared with patients without HDI, more patients with HDI had Cluster 2 mutations (59.8% vs. 38.5%, P = 0.002) and less had sarcopenia (35.9% vs. 54.8%, P = 0.005). Multivariate analysis showed that urine vanillylmandelic acid ≥ 58 μmol/day (adjusted odds ratio [OR] = 1.840, 95% confidence interval [CI] = 1.012–3.347, P = 0.046), tumour size ≥ 4 cm (adjusted OR = 2.278, 95% CI = 1.242–4.180, P = 0.008), and Cluster 2 mutations (adjusted OR = 2.199, 95% CI = 1.128–4.285, P = 0.021) were independent risk factors for intraoperative HDI, while sarcopenia (adjusted OR = 0.475, 95% CI = 0.266–0.846, P = 0.012) decreased the risk.ConclusionsBody composition and genotype were associated with intraoperative haemodynamics in patients with PPGL. Our results indicated that inclusion of body composition and genotype in the overall assessment of patients with PPGL helped to predict HDI during surgery, which could assist in implementing preoperative and intraoperative measures to reduce perioperative complications.
Clinical research progress of myocardial work in assessment and prediction of coronary artery disease in noninvasive pressure‐strain loop technique
Authors: Gao Lu , Wang Yinghui , Gao Ming , Chen Liping 
Published: September 2022

AbstractEarly identification and treatment of high‐risk coronary artery disease (CAD) is the main goal of current cardiovascular disease treatments. Speckle‐tracking ultrasound technology can quantify myocardial work using pressure‐strain loops. Because myocardial work takes into account the effect of the left ventricular systolic function afterload, it can more objectively reflect left ventricular myocardial mechanical function than the overall left ventricular longitudinal strain. Therefore, this technique is more widely used in diseases caused by CAD. This article reviews the evaluation and prediction of different CAD types using a variety of myocardial work parameters and provides a new method for clinical research to assess myocardial function, which is expected to become a new prediction method for CAD.
Potassium dihydrogen phosphate‐catalyzed synthesis of benzylpyrazolyl coumarin and pyrano [2,3‐c] pyrazole derivatives via cascade—One‐pot—Multicomponent reaction
Authors: Mathavan Sivagami , Yamajala Rajesh B. R. D. 
Published: September 2022

AbstractA simple one‐pot protocol for the synthesis of benzylpyrazolyl coumarin and pyrano [2,3‐c] pyrazole derivatives in the presence of potassium dihydrogen phosphate (KH2PO4) has been developed. This cascade reaction provides many advantages like environmentally benign reaction, mild reaction conditions, inexpensive catalyst, simple operation, easy workup procedure, a wide range of functional groups in good to excellent yields, and no need for column purification.
Transplanting China's ecological civilization to the Belt and Road Initiative: What will it take?
Authors: Brauteseth Bjørn Leif , Banik Dan 
Published: September 2022

AbstractThis article focuses on how Chinese state actors understand the concept of sustainable development and implement policies for achieving the 2030 Agenda and the Sustainable Development Goals (SDGs). We examine the concept of Ecological Civilization (EC) that has gained momentum within China and examine how EC is constructed around certain organizational principles that are difficult to export without expanding Beijing's political control abroad. Based on the example of a coal‐fired power plant in Kenya, we also explore the potential opportunities EC presents for African stakeholders to hold Chinese state actors to account for China's normative principles.
EXPLORE B: A prospective, long‐term natural history study of patients with acute hepatic porphyria with chronic symptoms
Authors: Cassiman David , Kauppinen Raili , Monroy Susana , Lee Ming‐Jen , Bonkovsky Herbert L. , Thapar Manish , Guillén‐Navarro Encarna , Minder Anna‐Elisabeth , Hale Cecilia , Sweetser Marianne T. , Ivanova Aneta 
Published: September 2022

AbstractOne‐year data from EXPLORE Part A showed high disease burden and impaired quality of life (QOL) in patients with acute hepatic porphyria (AHP) with recurrent attacks. We report baseline data of patients who enrolled in EXPLORE Part B for up to an additional 3 years of follow‐up. EXPLORE B is a long‐term, prospective study evaluating disease activity, pain intensity, and QOL in patients with AHP with ≥1 attack in the 12 months before enrollment or receiving hemin or gonadotropin‐releasing hormone prophylaxis. Data were evaluated in patients with more (≥3 attacks or on prophylaxis treatment) or fewer (<3 attacks and no prophylaxis treatment) attacks. Patients in the total population (N = 136), and more (n = 110) and fewer (n = 26) attack subgroups, reported a median (range) of 3 (0–52), 4 (0–52), and 1 (0–2) acute attacks, respectively, in the 12 months prior to the baseline visit. Pain, mood/sleep, digestive/bladder, and nervous system symptoms were each experienced by ≥80% of patients; most received hemin during attacks. Almost three‐quarters of patients reported chronic symptoms between attacks, including 85% of patients with fewer attacks. Pain intensity was comparable among both attack subgroups; most patients required pain medication. All groups had diminished QOL on the EuroQol visual analog scale and the European Organisation for Research and Treatment of Cancer Quality‐of‐life Questionnaire Core 30 versus population norms. Patients with AHP with recurrent attacks, even those having fewer attacks, experience a high disease burden, as evidenced by chronic symptoms between attacks and impaired QOL.
Cardiac resynchronization therapy in the presence of total atrioventricular block reduces long‐lasting atrial fibrillation episodes
Authors: Kugler Lara , Markendorf Susanne , Bachmann Marta , Eriksson Urs 
Published: September 2022

AbstractBackgroundThere is an ongoing debate on how cardiac resynchronization therapy (CRT) in the presence of total AV block affects atrial fibrillation (AF) episodes and symptoms in patients with AF.MethodsSeventy‐five patients with symptomatic, drug and ablation refractory AF received, irrespective of their left ventricular ejection fraction (EF), either a CRT device and underwent subsequent atrioventricular node (AVN) ablation or already had a total AV block and underwent CRT upgrade. Long‐lasting AF episodes (>48 h), left ventricular ejection fraction (LVEF), left ventricular end‐diastolic diameter (LVEDD), left atrial diameter (LAD), NTproBNP levels, EHRA score, and NYHA class had been monitored on the follow‐up.ResultsThe number of patients experiencing long‐lasting AF episodes (>48 h) and symptoms decreased significantly within 24 months after CRT implantation in the presence of total AV block (p < .001) from 57 (76%) to 25 (33.3%). Mean LAD decreased from 52 mm (IQR 48.0–56.0) to 48 mm (IQR 42.0–52.0, p < .001) and LVEDD from 54 mm (IQR 49.0–58.0) to 51 mm (IQR 46.5–54.0, p < .001).ConclusionA combination of total AVN block and biventricular pacing markedly reduces long‐lasting AF episodes, symptoms, left atrial diameter, and left ventricular end‐diastolic diameter.
Effect of non‐surgical therapy on plasma C‐reactive protein levels in patients with periodontitis: A single arm prospective clinical trial
Authors: Shah Bansari , Shah Monali , Geisinger Maria , Saleh Muhammad H. A. , Meghil Mohamed , Wang Hom‐Lay 
Published: September 2022

AbstractBackgroundThis study aimed to evaluate the effect of scaling and root planing (SRP) on levels of plasma C‐reactive protein (CRP).MethodsA total of 30 patients with advanced periodontitis as determined by Clinical Periodontal Sum Score (CPSS) were recruited. Venous whole blood samples were drawn to obtain serum samples from all participants at baseline and 1 month after SRP (post‐SRP). High‐sensitivity CRP (hs‐CRP) was measured by highly sensitive immunoturbidimetric assay. Wilcoxon signed‐rank test was used for data analysis. Spearman rank correlation analysis was conducted to test the correlations between CPSS and hs‐CRP at baseline and post‐SRP.ResultsThere was a statistically significant reduction in the post‐SRP CPSS values from the baseline values (z = 4.783, p < 0.0001). Similarly, there was a statistically significant reduction in the post‐SRP hs‐CRP levels from the baseline levels (z = 4.782, p < 0.0001). Moreover, there was positive association between the baseline levels of CPSS and hs‐CRP (ρ = 0.5703) and the post‐SRP values of CPSS and hs‐CRP (ρ = 0.7507).ConclusionThe present study suggests that SRP can significantly reduce the levels of CRP.
Demographic uncertainty and disease risk influence climate‐informed management of an alpine species
Authors: Gude Justin A. , DeCesare Nicholas J. , Proffitt Kelly M. , Sells Sarah N. , Garrott Robert A. , Rangwala Imtiaz , Biel Mark , Coltrane Jessica , Cunningham Julie , Fletcher Tammy , Loveless Karen , Mowry Rebecca , O'Reilly Megan , Rauscher Ryan , Thompson Michael 
Published: September 2022

AbstractClimate change is expected to disproportionately affect species occupying ecosystems with relatively hard boundaries, such as alpine ecosystems. Wildlife managers must identify actions to conserve and manage alpine species into the future, while considering other issues and uncertainties. Climate change and respiratory pathogens associated with widespread pneumonia epidemics in bighorn sheep (Ovis canadensis) may negatively affect mountain goat (Oreamnos americanus) populations. Mountain goat demographic and population data are challenging to collect and sparsely available, making population management decisions difficult. We developed predictive models incorporating these uncertainties and analyzed results within a structured decision making framework to make management recommendations and identify priority information needs in Montana, USA. We built resource selection models to forecast occupied mountain goat habitat and account for uncertainty in effects of climate change, and a Leslie matrix projection model to predict population trends while accounting for uncertainty in population demographics and dynamics. We predicted disease risks while accounting for uncertainty about presence of pneumonia pathogens and risk tolerance for mixing populations during translocations. Our analysis predicted that new introductions would produce more area occupied by mountain goats at mid‐century, regardless of the effects of climate change. Population augmentations, carnivore management, and harvest management may improve population trends, although this was associated with considerable uncertainty. Tolerance for risk of disease transmission affected optimal management choices because translocations are expected to increase disease risks for mountain goats and sympatric bighorn sheep. Expected value of information analyses revealed that reducing uncertainty related to population dynamics would affect the optimal choice among management strategies to improve mountain goat trends. Reducing uncertainty related to the presence of pneumonia‐associated pathogens and consequences of mixing microbial communities should reduce disease risks if translocations are included in future management strategies. We recommend managers determine tolerance for disease risks associated with translocations that they and constituents are willing to accept. From this, an adaptive management program can be constructed wherein a portfolio of management actions are chosen based on risk tolerance in each population range, combined with the amount that uncertainty is reduced when paired with monitoring, to ultimately improve achievement of fundamental objectives.
Beyond Laryngeal Clefts: Interarytenoid Injection Augmentation to Predict Success of Suture Augmentation in Children
Authors: Jáuregui Emmanuel J. , Abts Matthew F. , Dahl John P. , Parikh Sanjay R. , Horn David L. , Pickens Michael , Park Jason S. , DeMarre Kim , Hoang Jennifer , Johnson Kaalan 
Published: September 2022

ObjectiveTo assess the efficacy of interarytenoid injection augmentation (IAIA) and the ability of IAIA to predict response to interarytenoid suture augmentation (IASA) based on diet advancement on video fluoroscopic swallow studies (VFSS).MethodsRetrospective cohort analysis of patients with persistent pharyngeal dysphagia at a tertiary children's hospital with VFSS pre‐ and post‐IAIA were included between March 2011 and June 2019.ResultsMedian age of the 229 patients was 2.2 years (5.8 months–19 years). Interarytenoid mucosal height (IAMH) was found to be above the false vocal folds in 112 patients (53.4%) and at true vocal folds in 10 (4.9%) patients. On VFSS post‐IAIA, 95 (41.5%) patients were successfully advanced in recommended diet consistency, 115 (50.2%) were stable, and 19 (8.3%) needed thicker consistency. Paired t‐tests on pre‐ and post‐operative consistency scores showed significant improvement, p‐value of <0.0001, 95% confidence interval (CI; 0.50–0.85). Poisson regression found no covariates with significant association with improvement on IAIA. For IASA patients, 35/60 (58.3%) improved on post‐op VFSS. Paired t‐tests on pre‐ and post‐operative consistency scores showed significant improvement, p‐value of <0.0001, 95% CI (0.63–1.33). Positive predictive value for IAIA predicting response to IASA was 77% with positive likelihood ratio of 2.3. The response to IAIA versus no response to IAIA likelihood ratios were found to have a statistically significant difference (p < 0.05).ConclusionsOur study suggests IAIA yields objective improvement in swallow function on VFSS in nearly half of our patients and may be a reliable diagnostic tool to predict response to IASA in patients with persistent pharyngeal dysphagia with or without a laryngeal cleft.Level of Evidence3 Laryngoscope, 133:1749–1756, 2023