bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of the Get Active Questionnaire for Pregnancy: breaking down barriers to prenatal exercise
Authors: Davenport Margie H. , Neil-Sztramko Sarah , Lett Bridget , Duggan Mary , Mottola Michelle F. , Ruchat Stephanie-May , Adamo Kristi B. , Andrews Kate , Artal Raul , Beamish Nicole , Chari Radha , Forte Milena , Lane Kirstin N. , May Linda , Maclaren Kaleigh , Zahavich Ashley 
Published: April 2022

Evidence-based guidelines represent the highest level of scientific evidence to identify best practices for clinical/public health. However, the availability of guidelines do not guarantee their use, targeted knowledge translation strategies and tools are necessary to help promote uptake. Following publication of the 2019 Canadian Guideline for Physical Activity throughout Pregnancy, the Get Active Questionnaire for Pregnancy, and an associated Health Care Provider Consultation Form for Prenatal Physical Activity were developed to promote guideline adoption and use amongst pregnant individuals and health care providers. This paper describes the process of developing these tools. First, a survey was administered to qualified exercise professionals to identify the barriers and facilitators in using existing prenatal exercise screening tools. A Working Group of researchers and stakeholders then convened to develop an evidence-informed exercise pre-participation screening tool for pregnant individuals, building from previous tool and survey findings. Finally, end-user feedback was solicited through a survey and key informant interviews to ensure tools are feasible and acceptable to use in practice. The uptake and use of these documents by pregnant individuals, exercise, and health care professionals will be assessed in future studies. Novelty: Evidence supports the safety/benefits of exercise for most pregnant individuals; however, exercise is not recommended for a small number of individuals with specific medical conditions. The Get Active Questionnaire for Pregnancy and Health Care Provider Consultation Form for Physical Activity during Pregnancy identify individuals where prenatal exercise may pose a risk, while reducing barriers to physical activity participation for the majority of pregnant individuals.
Electromagnetic influence on hyperbolically symmetric sources in f(T) gravity
Authors: Bhatti M. Z. , Yousaf Z. , Hanif S. 
Published: April 2022

AbstractThe present study aims to see how gravitational modification, specifically, the f(T) gravitational field, where T is torsion scalar, impacts static fluid content with hyperbolic symmetry and electromagnetic field. We enlarge Herrera’s strategy (Herrera et al. in Phys Rev D 103:024037, 2021) to analyze the impact of electromagnetic field on f(T) gravity. We distinguish the stress–energy tensor by considering the ingredients of the tetrad field in the Minkowski co-ordinate frame, commencing with modified field equations. With the advent of negative density, this sort of fluid is supposed to surpass extreme physical conditions, enabling quantum impacts to be detected. We calculate a viable formulation of mass utilizing the Tolman mass from the viewpoint of f(T) gravity along with the electromagnetic field. The gravitational interference is repulsive, as made evident by the negative value of the Tolman mass. Also, we explored the structure scalars in f(T) gravity and found significant solutions in presence of electric charge.
Ultraviolet properties of Lifshitz-type scalar field theories
Authors: Zappalà Dario 
Published: April 2022

AbstractWe consider Lifshitz-type scalar field theories that exhibit anisotropic scaling laws near the ultraviolet fixed point, with explicit breaking of Lorentz symmetry. It is shown that, when all momentum dependent vertex operators are discarded, actions with anisotropy parameter $$z=3$$

z
=
3

in 3+1 dimensions generate Lorentz symmetry violating quantum corrections that are suppressed by inverse powers of the momentum, so that the symmetry is sensibly restored in the infrared region. In the ultraviolet region, the singular behavior of the corrections is strongly smoothened: only logarithmic divergences show up, producing very small changes of the couplings over a range of momentum of many orders of magnitude. In the particular case where all couplings are equal, the theory shows a Liouville-like potential and quantum corrections are exactly summable, giving an asymptotically free theory. However, the observed weakening of the divergences is not sufficient to avoid a residual fine tuning of the mass parameter at a very high energy scale, in order to recover a physically acceptable mass in the infrared region.
Syntactic Completeness of Proper Display Calculi
Authors: Chen Jinsheng , Greco Giuseppe , Palmigiano Alessandra , Tzimoulis Apostolos 
Published: April 2022

A recent strand of research in structural proof theory aims at exploring the notion of
analytic calculi
(i.e., those calculi that support general and modular proof-strategies for cut elimination) and at identifying classes of logics that can be captured in terms of these calculi. In this context, Wansing introduced the notion of
proper display calculi
as one possible design framework for proof calculi in which the analyticity desiderata are realized in a particularly transparent way. Recently, the theory of
properly displayable
logics (i.e., those logics that can be equivalently presented with some proper display calculus) has been developed in connection with generalized Sahlqvist theory (a.k.a. unified correspondence). Specifically, properly displayable logics have been syntactically characterized as those axiomatized by
analytic inductive axioms
, which can be equivalently and algorithmically transformed into analytic structural rules so the resulting proper display calculi enjoy a set of basic properties: soundness, completeness, conservativity, cut elimination, and the subformula property. In this context, the proof that the given calculus is
complete
w.r.t. the original logic is usually carried out
syntactically
, i.e., by showing that a (cut-free) derivation exists of each given axiom of the logic in the basic system to which the analytic structural rules algorithmically generated from the given axiom have been added. However, so far, this proof strategy for
syntactic completeness
has been implemented on a case-by-case base and not in general. In this article, we address this gap by proving syntactic completeness for properly displayable logics in any normal (distributive) lattice expansion signature. Specifically, we show that for every analytic inductive axiom a cut-free derivation can be effectively generated that has a specific shape, referred to as
pre-normal form
.
Unsupervised Dynamic Sensor Selection for IoT-Based Predictive Maintenance of a Fleet of Public Transport Buses
Authors: Killeen Patrick , Kiringa Iluju , Yeap Tet 
Published: April 2022

In recent years, big data produced by the Internet of Things has enabled new kinds of useful applications. One such application is monitoring a fleet of vehicles in real time to predict their remaining useful life. The consensus self-organized models (COSMO) approach is an example of a predictive maintenance system. The present work proposes a novel Internet of Things based architecture for predictive maintenance that consists of three primary nodes: the vehicle node, the server leader node, and the root node, which enable on-board vehicle data processing, heavy-duty data processing, and fleet administration, respectively. A minimally viable prototype of the proposed architecture was implemented and deployed to a local bus garage in Gatineau, Canada.The present work proposes improved consensus self-organized models (ICOSMO), a fleet-wide unsupervised dynamic sensor selection algorithm. To analyze the performance of ICOSMO, a fleet simulation was implemented. The J1939 data gathered from a hybrid bus was used to generate synthetic data in the simulations. Simulation results that compared the performance of the COSMO and ICOSMO approaches revealed that in general ICOSMO improves the average area under the curve of COSMO by approximately 1.5% when using the Cosine distance and 0.6% when using Hellinger distance.
Chemotherapy Coupled to Macrophage Inhibition Induces T-cell and B-cell Infiltration and Durable Regression in Triple-Negative Breast Cancer
Authors: Singh Swarnima , Lee Nigel , Pedroza Diego A. , Bado Igor L. , Hamor Clark , Zhang Licheng , Aguirre Sergio , Hu Jingyuan , Shen Yichao , Xu Yitian , Gao Yang , Zhao Na , Chen Shu-Hsia , Wan Ying-Wooi , Liu Zhandong , Chang Jeffrey T. , Hollern Daniel , Perou Charles M. , Zhang Xiang H.F. , Rosen Jeffrey M. 
Published: April 2022

Abstract

Immunosuppressive elements within the tumor microenvironment, such as tumor-associated macrophages (TAM), can present a barrier to successful antitumor responses by cytolytic T cells. Here we employed preclinical syngeneic p53 null mouse models of triple-negative breast cancer (TNBC) to develop a treatment regimen that harnessed the immunostimulatory effects of low-dose cyclophosphamide coupled with the pharmacologic inhibition of TAMs using either a small-molecule CSF1R inhibitor or an anti-CSF1R antibody. This therapeutic combination was effective in treating several highly aggressive TNBC murine mammary tumor and lung metastasis models. Single-cell RNA sequencing characterized tumor-infiltrating lymphocytes including Th cells and antigen-presenting B cells that were highly enriched in responders to combination therapy. In one model that exhibited long-term posttreatment tumor regression, high-dimensional imaging techniques identified the close spatial localization of B220+/CD86+-activated B cells and CD4+ T cells in tertiary lymphoid structures that were present up to 6 weeks posttreatment. The transcriptional and metabolic heterogeneity of TAMs was also characterized in two closely related claudin-low/mesenchymal subtype tumor models with differential treatment responses. A murine TAM signature derived from the T12 model was highly conserved in human claudin-low breast cancers, and high expression of the TAM signature correlated with reduced overall survival in patients with breast cancer. This TAM signature may help identify human patients with claudin-low breast cancer that will benefit from the combination of cyclophosphamide and anti-CSF1R therapy. These studies illustrate the complexity of the tumor immune microenvironment and highlight different immune responses that result from rational immunotherapy combinations.

Significance:
Immunostimulatory chemotherapy combined with pharmacologic inhibition of TAMs results in durable treatment responses elicited by Th cells and B cells in claudin-low TNBC models.
Induction chemotherapy with or without erlotinib in patients with head and neck squamous cell carcinoma amenable for surgical resection
Authors: Le Xiuning , Gleber-Netto Frederico O. , Rubin M. Laura. , Qing Yun , Du Robyn , Kies Merrill , Blumenschein, Jr George , Lu Charles , Johnson Faye M. , Bell Diana , Lewis Jeff , Zhang Jiexin , Feng Lei , Wilson Kaye , Marcelo-Lewis Kathrina , Wang Jing , Ginsberg Lawrence , Gillison Maura , Lee J. Jack. , Meric-Bernstam Funda , Mills Gordon B. , William William N. , Myers Jeffrey N. , Pickering Curtis R. 
Published: April 2022

Abstract
Purpose: Neoadjuvant chemotherapy prior to definitive surgery has been utilized widely for locally advanced oral squamous cell carcinoma (OSCC). We evaluated neoadjuvant erlotinib with platinum-docetaxel vs. placebo with platinum-docetaxel in stage III-IVB OSCC patients. Experimental Design: Patients with newly diagnosed stage III, IVA, IVB (AJCC 7th) OSCC amenable to surgical resection were included. Patients were randomized to receive up to 3 cycles of chemotherapy with concurrent erlotinib or placebo, followed by surgery. The primary endpoint was major pathologic response (MPR) rate, secondary endpoints included safety, overall (OS) and progression-free survival (PFS). Results: Fifty-two patients received at least one cycle of treatment and 47 were evaluable with surgical resection. MPR rate was not different between erlotinib (30%, 7/23) and placebo arms (41.7%, 10/24) (p=0.55). At median follow up of 26.5 months, there was no difference on OS or PFS between groups. Patients who received erlotinib with chemotherapy and achieved MPR (n=7) had no recurrence. The treatment-related adverse event rates were not different between the two groups (96% vs. 96%). However, rash, mostly low grade, was more common in the erlotinib arm (79% vs. 50%). Transcriptomic analysis in the pre-treatment samples indicated that genes in protein glycosylation and Wnt signaling pathways were associated with benefit in those treated with erlotinib plus chemotherapy. Conclusions: The addition of erlotinib to platinum-taxane chemotherapy was well-tolerated but did not induce higher rates of MPR or PFS or OS survival benefit. Patients who received chemotherapy with erlotinib and achieved major pathological responses had excellent clinical outcome.
What's in a Name? That Which We Call Immune Cells by Any Other Name Would All Smell as Sweet
Authors: Salgado Roberto , Loi Sherene 
Published: April 2022

Summary
In the FUTURE-C-Plus phase II trial, patients with advanced previously untreated immune-enriched triple-negative breast cancer achieved an overall objective response rate of 81.3% with the combination of camrelizumab, famitinib, and nab-paclitaxel. This supports that the quantity of immune cells is important for identifying those with response to treatments combined with PD-1–targeting immunotherapy.
See related article by Chen et al., p. 2807
Genetic Lineage Tracing of Pericardial Cavity Macrophages in the Injured Heart
Authors: Jin Hengwei , Liu Kuo , Huang Xiuzhen , Huo Huanhuan , Mou Jialing , Qiao Zengyong , He Ben , Zhou Bin 
Published: April 2022

Background:

Macrophages play an important role in cardiac repair after myocardial infarction (MI). In addition to the resident macrophages and blood-derived monocytes, Gata6
+
cavity macrophages located in the pericardial space were recently reported to relocate to the injured myocardium and prevent cardiac fibrosis. However, there is no direct genetic evidence to support it.

Methods:

We used dual recombinases (Cre and Dre) to specifically label Gata6
+
pericardial macrophages (GPCMs) in vivo. For functional study, we generated genetic systems to specifically ablate GPCMs by induced expression of DTR (diphtheria toxin receptor) or knockout of Gata6 (GATA binding protein 6) gene in GPCMs. We used these genetic systems to study GPCMs in pericardium intact MI model.

Results:
Dual recombinases-mediated genetic system targeted GPCMs specifically and efficiently. Lineage tracing study revealed accumulation of GPCMs on the surface of MI heart without deep penetration into the myocardium. We did not detect significant change of cardiac fibrosis or function of MI hearts after cell ablation or Gata6 knockout in GPCMs.

Conclusions:
GPCMs minimally invade the injured heart after MI. Nor do they prevent cardiac fibrosis and exhibit reparative function on injured heart. This study also underlines the importance of using specific genetic tool for studying in vivo cell fates and functions.
When can cropping rate compensate for increased vigilance?
Authors: Kurpiers Elizabeth M. , Weckerly Floyd W. 
Published: April 2022

Abstract
Herbivores use vigilance to reduce predation risk and interact socially, yet it imposes a foraging efficiency cost. As individuals spend more time with their head up being vigilant, time available to search for and ingest food decreases. We explored whether ungulates can strategically modify behaviours to compensate for vigilance costs via increased cropping rate when food searching time was near-zero and bite sizes were small. We compared the proportion of time individuals had their head up to their cropping rate (bites/observation length) in 271 observations of Roosevelt elk (Cervus elaphus roosevelti). Using a linear mixed-effect model, we estimated the head up–cropping rate relationship and found that elk cropping rate was constant across varying lengths of time spent with their head up, indicating no vigilance compensation occurred via increased cropping rate. We discuss settings when cropping rate compensation is expected and other behaviours that might mitigate vigilance costs.
Planning for Citizens’ Health: Towards an Integrated Approach to Air and Noise Pollution in the EU
Authors: Fermeglia Matteo , Pedrosa Kendro 
Published: April 2022

Abstract
The outbreak of covid-19 Pandemic has unfolded the close relationship between good environmental quality in urban areas and public health. The abrupt closure of economic activities through lockdown measures have shown how the concentration of air pollutants and noise from different sources are long-standing, major environmental and health issues in the European Union, especially in highly populated urban areas. Scientific evidence underscores that simultaneous exposure to air pollutants and noise constitutes a mutually reinforcing threat to human health. However, the current regulatory approaches in the European legislation still fall short in addressing the issues of air and noise pollution in a comprehensive and coordinated manner. The lack of harmonized and effective planning regime for air and noise pollution runs against the objectives pursued by the European Green Deal, whereas an effective and integrated response to environmental issues should underpin EU policies in the post Covid-19 recovery. This contribution thus analyzes two key EU legal regimes addressing air and noise pollution, namely Directive 2008/50/ec and Directive 2002/49/ec, respectively, to appraise their mutual pitfalls against the said need to adopt an integrated response to air and noise pollution. Moreover, the paper sheds further light on innovative approaches, such as integrated urban planning, citizen science and Internet of Things as key means to enhance cities’ resilience and support the implementation of effective legal responses to air and noise pollution.
Exploring Norway’s Ocean Governance Aptitude against United Nations Global Compact Principles for Sustainable Oceans
Authors: Fasoulis Ioannis 
Published: April 2022

Abstract
For many decades, the United Nations Convention on the Law of the Sea (unclos) has provided the legal framework for the development of regulations for the protection of the oceans and marine resources. Further to that, and in an ever-changing policy and legal landscape, the United Nations Global Compact (ungc), with its sub-principles for the protection of the oceans, refers to one of the many United Nations (UN) voluntary initiatives that seeks to provide a framework for responsible business practices across maritime sector. In addition, and as a move to comply with the recent United Nations Sustainable Development Goals (sdg s), the ungc has been revised to meet the requirements of sdg 14 for underwater protection and sustainable ocean business conduct. In the wake of such trends, this study explores the context of Norway’s governance framework and, in particular, the extent to which this regime has addressed the principles of the United Nations Global Compact for Sustainable Oceans. Framed by a socio-legal methodological approach, it achieves this by reviewing and contrasting Norwegian ocean policy and regulatory structure with ungc principles for sustainable ocean and marine resource use. We conclude that Norwegian ocean policy and legal status indicate positive transitional standards and perspectives for their harmonization with the ungc principles and, consequently, with the requirements of the sdg 14.
‘Chinese’ or ‘Local’?
Authors: Grigorichev Konstantin , Koreshkova Iuliia 
Published: April 2022

Abstract
The article discusses the appearance of complex relations around the production and supply chains of agricultural products of ‘Chinese’ greenhouses in the Siberian suburbs. The authors attempt to analyse the contradictory relations as an assemblage in Manuel DeLanda’s theoretical optics. Attempt to explain how the market manipulation of vegetable identification (‘Chinese’/‘local’) conceals a complex social assemblage with a multiplicity of identities, which, through the practices of translation, allows the assemblage to be combined. The study demonstrates how ‘Chinese’ actors engage material resources, through assemblages with local residents and the authorities, which allows them to acquire a symbolic resource of ‘locality’ and get involved in the situation of ‘local capitalism’. For local residents, this is an opportunity to integrate into capitalist relations through the sale of the symbolic resource ‘locality’. Such a sale of ‘locality’ is only possible if there are stable perceptions of ‘Chineseness’, in the maintenance of which the local population are engaged.
Long-term effects of baseline on-treatment platelet reactivity in patients with acute coronary syndrome and thrombocytopenia undergoing percutaneous coronary intervention
Authors: Liu Ru , Li Tianyu , Yuan Deshan , Chen Yan , Tang Xiaofang , Gao Lijian , Zhang Ce , Jia Sida , Zhu Pei , Xu Ou , Gao Runlin , Xu Bo , Yuan Jinqing 
Published: April 2022

Objective To analyse the association between on-treatment platelet reactivity (TPR) and long-term outcomes of patients with acute coronary syndrome (ACS) and thrombocytopenia (TP) in the real world. Methods This prospective observational study enrolled patients with coronary artery disease (CAD) that underwent percutaneous coronary intervention (PCI). Patients with ACS and TP under dual antiplatelet therapy were selected for analysis. The 2- and 5-year clinical outcomes were evaluated among patients with high on-treatment platelet reactivity (HTPR), low on-treatment platelet reactivity (LTPR) and normal on-treatment platelet reactivity (NTPR), as tested by thromboelastogram at baseline. Results A total of 10 724 patients with CAD that underwent PCI were identified. Of these, 474 patients with ACS and TP met the inclusion criteria: 124 (26.2%) with HTPR, 163 (34.4%) with LTPR and 187 (39.5%) with NTPR. The 5-year rates of all-cause death, major adverse cardiovascular and cerebrovascular events, cardiac death, myocardial infarction, revascularization, stroke and bleeding were not significantly different among the three groups. Multivariate Cox regression analysis demonstrated that patients with HTPR were not independently associated with any of the 5-year endpoints compared with patients with NTPR. Conclusions TPR at baseline was not independently associated with long-term outcomes in patients with ACS and TP that underwent PCI.
The effect of alkyl chain length of (R)-3-Hydroxybutyric alkyl ester on antibacterial activity and its antibacterial mechanism
Authors: Cheng Zao , Gao Junfei , Liu Qianqian , Gu Qun 
Published: April 2022

This work describes the relationship between the antibacterial activity and the ester chain length (C1-C8) of ( R)-3-Hydroxybutyric (( R)-3-HB) alkyl esters that synthesized from ( R)-3-HB acid (( R)-3-HBA) by esterification reaction. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) decrease as the length of the ( R)-3-HB alkyl ester chain increases from 1 to 6, but ( R)-3-HB-C7 and ( R)-3-HB-C8 have their own rules for different microorganisms. Among them, the ( R)-3HB-C6 has the relatively best antibacterial and antifungal properties, which MIC were 1.95 mg mL−1 against E. coli and S. aureus; 0.98 mg mL−1 against C. albicans and B. subtilis; 0.49 mg mL−1 against A. niger. Finally, the antimicrobial mechanisms of the ( R)-3HB-C6 are revealed, and these include disruption of biofilm and the bacterial wall/membrane, leakage of the intracellular content, and change in the transmembrane potential. These results imply the potential application of ( R)-3-HB alkyl ester as new antimicrobial agents; future research can use this as an antibacterial element to synthesize new polymer materials or agents with high-efficiency antibacterial activity.