bluuebunny/crossref_metadata_2025_split huggingface dataset:
OCD and ASD Diagnosis: a case review
Authors: Huerga García L. , Hernández Padrón E. , Casanova Gracia N. , Torres Nieves N. , Gómez Pérez P. 
Published: September 2022

IntroductionIt’s well known the challenge of differential diagnosis between Obssesive compulsive disorder and autism since their symptoms (intrusive, recurrent thoughts and repetitive behaviours) often overlap.ObjectivesWe report a case of a 14 years old boy diagnosed of ASD who was hospitalized for the first time due to difficult management of repetitive behaviours that made him incapable of doing basic activities without help. To interrupt them led to anxiety, aggressive responses and to insistence on sameness behaviours. Only with this information and with the literature research we made, anyone could tell the problem was probably an ASD symptom. However, during his evolution it was difficult to know whether this behaviour was due to ASD or OCD: after adjusting the medication, and when he started trusting his therapists, he told us about a theory he believed so he could explain the uncomfortable ideas that crossed his mind more than often, so he used those behaviours as an anxiety-reduction technique. This new situation was the fuel to make the present review.MethodsTo report a case.ResultsThe results are included in the “conclusions” section.ConclusionsAlthough there is an ongoing debate concerning the nature of the symptoms in ASD versus those observed in OCD, there are commonly used criteria to differentiate them according to the articles we reviewed:
DisclosureNo significant relationships.
Psychogenic epidemic - mass hysteria phenomena in Portugal
Authors: Costa A. , Jesus S. , Almeida M. , Alcafache J. 
Published: September 2022

IntroductionMass hysteria also called mass psychogenic illness (MPI), defined as a social phenomenon, consists of collective anxiety due to a perceived threat and can culminate in a cascade of symptoms suggestive of organic disease without an identifiable cause. Its history dates back to the 14th century and impacts people from all cultures and regions of the world. Before the 20thcentury, MPI emerged across Europe, often in socially isolated convents, in highly stressful environments.Objectives
The aim of this study is to explore the available literature on mass hysteria phenomena in Portugal, historical origins, applications and eventual position in modern psychiatric semiology.MethodsNon-systematic review of literature published in Medline/Pubmed. Search terms included: mass hysteria, nocebo, groupthink, emotional contagion.Results

In Portugal two great phenomena of mass hysteria were described. In 1917, the “sun miracle” occurred, where thousands of individuals reported having seen the sun rotating in the sky and changing its size and colours. Years later, more than 300 students from 14 schools described the same symptoms: dizziness, dyspnea and rash, without an identifiable cause. In common these young people had “sugar strawberries”. In May 2006, the young people in the television series were infected with a vírus, and clinical picture was similar to that presented by young people in real life. For the first time, a fictional illness on television triggered an illness in real life.ConclusionsMore studies should be carried out on these phenomena as their early recognition can have a tremendous impact on the ease of identification, diagnosis and treatment.DisclosureNo significant relationships.
Understanding the surface segregation of solute atoms in Sn-Bi–based solder from first principles
Authors: Sun Lu , Chen Li , Li Guoping , Tong Zhenfeng 
Published: September 2022

Abstract
Low-temperature Sn-Bi solder has wide application in the field of electronic packaging due to its low melting point and good wettability. The formation of Bi-rich phase and intermetallic compound is the major concern for the reliability of Sn-Bi solder joints. We employed first-principles calculations to understand the segregation of Bi and the third elements to the surface of Sn. The effects of alloying elements on inhibiting the Bi surface segregation were described. Our calculations show that the Bi surface segregation could be effectively alleviated by the addition of Ag, Ga, Ni, and In, along with the reduction of further possible formation of intermetallic compounds in the Sn-Bi–based solders. The results could be interpreted by the enhanced bond orders between Bi and its neighboring Sn, alloying elements.
Search for the singlet vector-like lepton through the pair production in the Wν

τ
channel at the ILC
Authors: Li Haitao , Chao Jinjin , Zhang Guoqing 
Published: September 2022

Abstract
We study the pair production of the vector-like lepton singlet

decaying into

at the International Linear Collider (ILC) with the center-of-mass

in a simplified model. Considering the polarized degrees of electron and photon beams

,

, we implement a detailed detector simulation of the signal and backgrounds. For comparison, we investigate the search at leptonic channel and hadronic channel of the W boson, respectively. We find that the ILC can exclude (discover) the region

[180 GeV, 240 GeV] with an integrated luminosity of

([0.305, 1.102]

) in the hadronic channel, and can exclude (discover) the region

[180 GeV, 240 GeV] with an integrated luminosity of [1.83, 19.4]

([11.7, 117.8]

) in the leptonic channel. If these two results are combined, we find that the ILC can exclude (discover) the region

[180 GeV, 240 GeV] with lower integrated luminosity.
Predictive Gestational Diabetes Biomarkers With Sustained Alterations Throughout Pregnancy
Authors: Heath Hannah , Luevano Jennifer , Johnson Catherine M , Phelan Suzanne , La Frano Michael R 
Published: September 2022

AbstractGestational diabetes mellitus (GDM) results in an increased risk of pre- and postpartum health complications for both mother and child. Metabolomics analysis can potentially identify predictive biomarkers and provide insight into metabolic alterations associated with GDM pathogenesis and progression, but few metabolomics studies investigate alterations observed across the first and third trimester. We hypothesize that metabolites altered in first-trimester GDM that remain altered in late pregnancy may best inform interventions. Metabolomic studies comparing plasma and serum metabolite alterations in GDM vs non-GDM pregnancies were retrieved by searching PubMed, Medline, and CINAHL Plus databases. The present scoping review summarizes the metabolites found to be consistently altered throughout the course of GDM and proposes mechanisms that explain how these metabolic perturbations relate to GDM development and progression. Metabolites involved in fatty acid metabolism, reductive carboxylation, branched-chain amino acid metabolism, cell membrane lipid metabolism, purine degradation, and the gut microbiome were found to be altered throughout GDM pregnancies, with many of these pathways showing mechanistic links to insulin resistance, inflammation, and impaired cell signaling. Future studies are required to investigate if normalization of these perturbed pathways can be the targets of interventions.
Differences in the length of postoperative care of endoscopic endonasal surgery in simple and complex surgical procedure groups
Authors: Sutikno Budi , Fauzi Fuad , Ardani Diar Mia , Mailasari Anna 
Published: September 2022

Background: The rapid development of endoscopic endonasal surgery has made the procedure widely used in nasal and sinus surgery. Endoscopic endonasal surgery is a minimally invasive procedure, but the possibility of postoperative damage to the sinonasal mucosa cannot be ruled out. The aim of this study was to analyze the difference in the length of postoperative care between complex and simple endoscopic endonasal surgeries which can be used as a reference in planning postoperative care. Methods: This was a retrospective cross-sectional observational study. The participants were divided into two groups, i.e., simple, and complex surgical procedures groups. The simple procedure group consisted of middle meatal anstrostomy, frontal sinusotomy, sphenoidectomy, uncinectomy, endoscopic septoplasty, and endoscopic turbinoplasty. The complex procedure group included pansinus surgery and or at least total ethmoidectomy. The length of postoperative care between the two groups were measured and analyzed using the Chi-square test. Results: The median length of care in the complex procedure group was significantly longer than that in the simple procedure group (p = 0.028), 12 weeks and 9 weeks, respectively. The number of postoperative outpatient visits was significantly less in the simple procedure group compared with the complex procedure group (Median 4 vs. 5; p=0.015). There was a significant correlation between length of care and the endonasal endoscopic surgical procedure group (p = 0.023). Conclusions: The complex endoscopic endonasal surgery group required a longer length of care and more postoperative outpatient visit than the simple procedure group.
A training curriculum for retrieving, structuring, and aggregating information derived from the biomedical literature and large-scale data repositories.
Authors: Rinchai Darawan , Chaussabel Damien 
Published: September 2022

Background: Biomedical research over the past two decades has become data and information rich. This trend has been in large part driven by the development of systems-scale molecular profiling capabilities and by the increasingly large volume of publications contributed by the biomedical research community. It has therefore become important for early career researchers to learn to leverage this wealth of information in their own research. Methods: Here we describe in detail a training curriculum focusing on the development of foundational skills necessary to retrieve, structure, and aggregate information available from vast stores of publicly available information. It is provided along with supporting material and an illustrative use case. The stepwise workflow encompasses; 1) Selecting a candidate gene; 2) Retrieving background information about the gene; 3) Profiling its literature; 4) Identifying in the literature instances where its transcript abundance changes in blood of patients; 5) Retrieving transcriptional profiling data from public blood transcriptome and reference datasets; and 6) Drafting a manuscript, submitting it for peer-review, and publication. Results: This resource may be leveraged by instructors who wish to organize hands-on workshops. It can also be used by independent trainees as a self-study toolkit. The workflow presented as proof-of-concept was designed to establish a resource for assessing a candidate gene’s potential utility as a blood transcriptional biomarker. Trainees will learn to retrieve literature and public transcriptional profiling data associated with a specific gene of interest. They will also learn to extract, structure, and aggregate this information to support downstream interpretation efforts as well as the preparation of a manuscript. Conclusions: This resource should support early career researchers in their efforts to acquire skills that will permit them to leverage the vast amounts of publicly available large-scale profiling data.
Characterization of a novel variant in the HR1 domain of MFN2 in a patient with ataxia, optic atrophy and sensorineural hearing loss
Authors: Sharma Govinda , Zaman Mashiat , Sabouny Rasha , Joel Matthew , Martens Kristina , Martino Davide , de Koning A.P. Jason , Pfeffer Gerald , Shutt Timothy E. 
Published: September 2022

Background: Pathogenic variants in MFN2 cause Charcot-Marie-Tooth disease (CMT) type 2A (CMT2A) and are the leading cause of the axonal subtypes of CMT. CMT2A is characterized by predominantly distal motor weakness and muscle atrophy, with highly variable severity and onset age. Notably, some MFN2 variants can also lead to other phenotypes such as optic atrophy, hearing loss and lipodystrophy. Despite the clear link between MFN2 and CMT2A, our mechanistic understanding of how dysfunction of the MFN2 protein causes human disease pathologies remains incomplete. This lack of understanding is due in part to the multiple cellular roles of MFN2. Though initially characterized for its role in mediating mitochondrial fusion, MFN2 also plays important roles in mediating interactions between mitochondria and other organelles, such as the endoplasmic reticulum and lipid droplets. Additionally, MFN2 is also important for mitochondrial transport, mitochondrial autophagy, and has even been implicated in lipid transfer. Though over 100 pathogenic MFN2 variants have been described to date, only a few have been characterized functionally, and even then, often only for one or two functions. Method: Several MFN2-mediated functions were characterized in fibroblast cells from a patient presenting with cerebellar ataxia, deafness, blindness, and diffuse cerebral and cerebellar atrophy, who harbours a novel homozygous MFN2 variant, D414V, which is found in a region of the HR1 domain of MFN2 where few pathogenic variants occur. Results: We found evidence for impairment of several MFN2-mediated functions. Consistent with reduced mitochondrial fusion, patient fibroblasts exhibited more fragmented mitochondrial networks and had reduced mtDNA copy number. Additionally, patient fibroblasts had reduced oxygen consumption, fewer mitochondrial-ER contacts, and altered lipid droplets that displayed an unusual perinuclear distribution. Conclusion: Overall, this work characterizes D414V as a novel variant in MFN2 and expands the phenotypic presentation of MFN2 variants to include cerebellar ataxia.
Use of 3d printing technology in the treatment of microtia and other outer ear deformities
Authors: Rezmer Jakub , Wasilewska Inga , Świątek Łukasz 
Published: September 2022

Introduction:
Microtia and other outer ear deformations may cause a lot of psychical, social, and mental stress for a patient. In order to surgically treat it, we need a very experienced plastic surgeon specializing in such operations. With the use of 3D printing technology, such as fused deposition modeling or a sacrificial layer process there are a lot of possibilities starting from creating aids for plastic surgeons to printing ear prosthesis from live cells.
Objective:
The study's objective was to research, review and compare data available on PubMed about the use of 3D printing in the treatment of microtia and other ear deformations.
A brief description of the state of knowledge:
With the current state of knowledge, with the 3D printing technology, we can quickly create highly individualized and helpful training aids for plastic surgeons that would help them during operations. There is also a possibility of developing a personalized splint that would help correct the ears better than conventional methods. What’s more, we can also print prosthetics, not only with the use of conventional materials used in 3D printing but also with live chondrocytes and adipocytes that were able to chondro and adipogenesis, respectively.
Conclusions:
There are a couple of ways we can use 3D printing in the treatment of outer ear deformities. The most promising is printing with live cells, but we need more research to develop better methods and techniques to use in the future prosthetics.
On the Design of Public Debate in Social Networks
Authors: Grabisch Michel , Mandel Antoine , Rusinowska Agnieszka 
Published: September 2022

How to Avoid Polarization in Social Networks In order to facilitate social interactions and the design of deliberative and efficient institutions, a social planner should ensure that diverse opinions can be sustained and debated and ensuring social cohesion. Grabisch et al. provide a theory of the efficient design of public debate. They develop a model of the coevolution of opinions and social relations that allow them to frame this problem in a formal setting. This model of opinion dynamics accounts for the persistence of heterogeneous opinions in society (“strong diversity”) and the dynamic interactions between opinions and social connections. The social planner faces a trade-off between fostering the convergence of opinions in society and increasing the risk of polarization and instability. To resolve this trade-off, the social planner must account for both structural and behavioral characteristics: how fragile is the social network and to what extent individuals tolerate disagreement with their peers.
Effect of dietary lysine on the growth performance of Pangasius hypophthalmus
Authors: Rachmawati Diana , Nurhayati Dewi 
Published: September 2022

The success of intensive striped catfish (Pangasius hypophthalmus) cultivation requires quality feed that contains not only protein according to fish needs but also a complete essential amino acid profile to support the fish growth. One solution to overcome this problem is done through the addition of lysine in the feed commercial. This study aimed to examine the effect of lysine addition on the efficiency of feed utilization, growth and body composition of striped catfish (P. hypophthalmus). The study consisted of 4 (four) treatments those were with dosages of 0% / kg of feed (A); 0.6% / kg of feed (B); 1.2% / kg of feed (C); and 2.4% / kg of feed (D) of lysine for every kg of feed. The experimental diet in this study was a commercial feed in the form of pellets which was added with the lysine. A fixed feeding rate of 5%/weight of biomass/day was applied at frequency 3 times a day. The experimental fish used were striped catfish fingerling has an average weight of 4.13 ± 0.26 g/individuals. The results showed that the addition 1,2% / kg of lysine to the diet increased SGR, EFU, FCR, PER and protein content of the body composition of striped catfish.
Efficient graphene-based circularly polarized MIMO antenna for THz applications
Authors: Vamsi ChunchulaSai , Dwivedi Ajay Kumar , Bharti Gagandeep , Verma Vandna Rani , Sharma Anand 
Published: September 2022

In this paper, a graphene-based (MIMO) antenna is designed and examined. Two unique properties of the proposed terahertz (THz) MIMO antenna are (1) circular polarization is achieved through an asymmetrical cross slot, etched over the graphene patch; and (2) a bidirectional radiation pattern is achieved through oppositely oriented identical antenna ports. Mutual coupling between the antenna ports is less than

−

35

d
B

. Due to the inclusion of the pattern diversity concept, a low value of envelope correlation coefficient is achieved. The proposed THz radiator operates over the frequency range of 4.67–4.87 THz, along with a 3 dB axial ratio between 4.76 and 4.81 THz. This type of antenna is widely employable for biomedical applications.
Impact of long-term COVID on workers: A systematic review protocol
Authors: do Prado Camila Bruneli , Emerick Giselly Storch , Cevolani Pires Luciana Bicalho , Salaroli Luciane Bresciani 
Published: September 2022

Introduction
Part of the patients infected by COVID-19 have at least one lasting sequel of the disease and may be framed in the concept of long Covid. These sequelae can compromise the quality of life, increase dependence on other people for personal care, impair the performance of activities of daily living, thus compromising work activities and harming the health of the worker. This protocol aims to critically synthesize the scientific evidence on the effects of Covid-19 among workers and its impact on their health status and professional life.

Method
Searches will be performed in MEDLINE via PubMed, EMBASE, Cochrane Library Central, Web of Science, Scopus, LILACS and Epistemonikos. Included studies will be those that report the prevalence of long-term signs and symptoms in workers and/or the impact on their health status and work performance, which may be associated with Covid-19 infection. Data extraction will be conducted by 3 reviewers independently. For data synthesis, a results report will be carried out, based on the main outcome of this study.

Discussion
This review will provide evidence to support health surveillance to help decision makers (i.e. healthcare providers, stakeholders and governments) regarding long-term Covid.

Trial registration
PROSPERO registration number: CRD42021288120. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021288120.
Tachycardia in hyperthyroidism: Not so common
Authors: Go Muriel Tania , George Amrutha Mary , Tahsin Bettina , Fogelfeld Leon 
Published: September 2022

ObjectiveThe commonly held association of hyperthyroidism with sinus tachycardia and widened pulse pressure (PP) has not been reassessed in decades despite patients with hyperthyroidism in current practice not always present with these signs. The study objective was to assess prevalence and variability of sinus tachycardia and widened PP in present day among individuals with different degrees of hyperthyroidism.MethodsData was collected retrospectively from 248 adult patients in an outpatient setting with biochemical evidence of hyperthyroidism, recorded heart rate (HR) and blood pressure (BP) who were not treated with medications that can influence these parameters.ResultsMean age was 42.0 ± 14.2 years with 66.9% being female. Median free thyroxine (fT4) level was 3.49 (IQR 2.42–4.58) ng/dL and thyroid stimulating hormone (TSH) 0.02 (IQR 0.01–0.03) mIU/L. Tachycardia, defined as HR >100 bpm, was present in 28.2%. In the lowest and highest fT4 quartiles, tachycardia was present in 16.4% and 38.7% respectively. Using logistic regression, tachycardia was associated with higher fT4 and diastolic BP. More lenient outcome of tachycardia with HR >90 bpm was seen in 47.2%. Widened PP, defined as >50 mmHg, was observed in 64.1% of patients and correlated with higher fT4 and BP.ConclusionsTachycardia is not a common feature of hyperthyroidism today. The relatively infrequent finding of tachycardia in this study compared to older studies may reflect differences in the way medicine is practiced today. The increased ordering of thyroid function tests most likely unmasked cases of mild or asymptomatic thyrotoxicosis. A widened PP was a more prevalent clinical finding in this study.
The role of birth month in the burden of hospitalisations for acute lower respiratory infections due to respiratory syncytial virus in young children in Croatia
Authors: Li You , Batinović Ena , Milić Petra , Markić Joško 
Published: September 2022

Background
Birth month was an important risk factor for respiratory syncytial virus (RSV) hospitalisation in infants. However, little is known about the role of birth month in RSV hospitalisation in finer age bands during infancy, which is relevant to strategies for RSV passive immunisations for infants. We aimed to understand the role of birth month in the burden of RSV-associated acute lower respiratory infection (ALRI) hospitalisation in finer age bands of the first year of life.

Methods
In this retrospective study, we analysed the hospitalisation records during 2014–19 at the University Hospital of Split, Split-Dalmatia County, Croatia. We estimated all-cause and RSV associated ALRI hospitalisation rates among children under five years, with a focus on infants by finer age band and birth month.

Results
We included 1897 ALRI hospitalisations during the study period. Overall in children under five years, annual hospitalisation rate was 14.66/1000 (95% CI: 14.01–15.34) for all-cause ALRI, and was 7.56/1000 (95% CI: 6.83–8.34) for RSV-ALRI. RSV-ALRI hospitalisation rate was highest in infants aged 28 days–<3 months (61.15/1000, 95% CI: 52.91–70.31). Infants born in November, December and January (2–3 months before RSV peak) had the highest hospitalisation rates during infancy. Depending on the birth month of infants, the risk of RSV-ALRI hospitalisation peaked at different months of age; infants who were born in September had the highest RSV-ALRI hospitalisation rate at the age of 3–<6 months.

Conclusions
Our study underlines the importance of birth month in planning RSV immunisation strategies for infants, and provides useful baseline data for effectiveness analysis of novel RSV prophylactic products.