bluuebunny/crossref_metadata_2025_split huggingface dataset:
The promise of telemedicine in Pakistan: A systematic review
Authors: Mahdi Syed Sarosh , Allana Raheel , Battineni Gopi , Khalid Tamsal , Agha Daniyal , Khawaja Mariam , Amenta Francesco 
Published: January 2022

AbstractBackgroundTelemedicine offers the possibility of provision of medical assistance to remote patients, and it has great potential in developing countries like Pakistan. Telemedicine solves logistical barriers, gives support to weak health systems, and helps to establish worldwide networks of healthcare professionals. Because of the high implementation costs, it is not possible yet to adopt telehealth systems for low‐ and middle‐income nations.ObjectiveTo present a revision of region‐based telemedical services in Pakistan.MethodsLibraries such as PubMed (Medline), CINAHL (Cumulative Index to Nursing and Allied Health Literature), Scopus (EMBASE), and Google Scholar were used for document search. Newcastle‐Ottawa Scale (NOS) was adopted to conduct study quality. Many of the studies (n−8) included in the review were of high quality as assessed through the Newcastle‐Ottawa scale. Selected study characteristics were further analyzed based on different parameters such as publication year, sample size, study design, methods, motivation, and outcomes.ResultsSearch produced 955 articles and 11 items were ultimately selected to conduct the review. These studies were further characterized as region‐based telemedicine implementation. Out of 11, eight studies were conducted in the urban region and three studies were conducted in the rural areas of Pakistan. Many studies produced evidence on telehealth interventions by smartphone services such as SMS, apps, and web‐based telemedicine.ConclusionsTelehealth interventions such as mHealth, eHealth, telemedicine, and telepharmacy in Pakistan were introduced starting from the last two decades. For obtaining the full benefits of these technologies, it is necessary that they but certainly need to become an integral part of Pakistan's current health infrastructure.
Pelvic floor dysfunction at transperineal ultrasound and chronic constipation in women with endometriosis
Authors: Raimondo Diego , Cocchi Laura , Raffone Antonio , Del Forno Simona , Iodice Raffaella , Maletta Manuela , Aru Anna Chiara , Salucci Paolo , Ambrosio Marco , Mollo Antonio , Youssef Aly , Casadio Paolo , Seracchioli Renato 
Published: January 2022

AbstractObjectiveTo assess the association between sonographic findings at transperineal ultrasound (TPU) and chronic constipation (CC) in women with endometriosis.MethodsAn observational prospective cohort study was performed by enrolling all women with endometriosis scheduled for surgery between September 2019 and October 2020. Women underwent TPU at rest and during Valsalva maneuver evaluating levator‐hiatal‐area (LHA), antero‐posterior diameter (APD), and levator ani muscle (LAM) coactivation. Ultrasound findings were compared between women with and without CC in the whole study population, and subsequently in two subgroups (only ovarian endometriosis and deep infiltrating endometriosis [DIE]).ResultsIn all, 87 women were enrolled: 29 (33%) with CC and 58 (67%) without CC. Women with endometriosis and CC showed a smaller LHA during Valsalva, less LHA and APD enlargement from rest to maximum Valsalva, and a higher prevalence of LAM coactivation compared with women without CC. In the ovarian subgroup, women with CC had smaller LHA at Valsalva, less enlargement of LHA and APD from rest to maximum Valsalva, and higher prevalence of LAM coactivation compared with non‐CC patients. In the DIE subgroup, TPU did not significantly differ between CC and non‐CC patients.ConclusionTPU signs of pelvic floor muscle hypertonia are more frequent in endometriosis patients with CC compared with those without constipation, particularly in women affected by isolated ovarian endometriosis.
Impact of nerve‐sparing posterolateral parametrial excision for deep infiltrating endometriosis on postoperative bowel, urinary, and sexual function
Authors: Ianieri Manuel Maria , Raimondo Diego , Rosati Andrea , Cocchi Laura , Trozzi Rita , Maletta Manuela , Raffone Antonio , Campolo Federica , Beneduce Giuliana , Mollo Antonio , Casadio Paolo , Raimondo Ivano , Seracchioli Renato , Scambia Giovanni 
Published: January 2022

AbstractObjectiveTo evaluate the functional outcomes of nerve‐sparing surgery for deep infiltrating endometriosis (DIE) with or without posterolateral parametrectomy.MethodsA multicenter, observational, retrospective, cohort study was performed including all symptomatic women who underwent nerve‐sparing laparoscopic excision of DIE and preoperative and postoperative assessment of functional outcomes through validated questionnaires between April 2019 and March 2020. Women with posterolateral parametrial DIE (P‐group) and women with no parametrial involvement (NP‐group) were compared in terms of preoperative and postoperative functional outcomes related to pelvic organs assessed through validated questionnaires (KESS and GIQLI for bowel function, BFLUTS for urinary function, and FSFI for sexual function); pain symptoms at 3‐month follow up assessed through an 11‐point visual analogue scale (VAS) for dyschezia, dysmenorrhea, dyspareunia and chronic pelvic pain; surgical outcomes; and rate of urinary voiding dysfunction at 3‐month follow up.ResultsOne‐hundred patients were included: 69 in the P‐group and 31 in the NP‐group. Preoperative and postoperative values of questionnaires, pain symptoms, and postoperative complication rates were comparable between the two groups, except for postoperative dyspareunia and sexual dysfunction, which were statistically higher in the P‐group. Only patients in the P‐group experienced urinary voiding dysfunction, but no statistical significance was reached (P = 0.173).ConclusionPosterolateral parametrectomy for DIE appears to be associated with a higher risk of postoperative dyspareunia and sexual dysfunction.
Utilizing social and behavioral change methods in clinical pharmacy initiatives
Authors: Hemenway Alice N. , Meyer‐Junco Laura , Zobeck Bryan , Pop Marianne 
Published: January 2022

AbstractPharmacists are often involved in creating, implementing, and evaluating initiatives that aim to improve medication use. Pharmacy initiatives can occur in various settings, can involve interactions with patients or prescribers to optimize medication use, and incorporate information from multiple sources. Similar to pharmacy initiatives, public health initiatives are heterogeneous, complex, and work with the public to improve health behaviors in a variety of settings. Various program planning and health behavior change techniques are utilized in the planning of public health programs. Community‐based public health programs designed using social and behavioral theories have shown improved outcomes when compared with programs not based on theory. Given the overlapping objectives for planning community‐based public health programs and pharmacy initiatives, the use of social and behavioral theories may provide pharmacists with an additional tool to assist in creation of multi‐layered, effective pharmacy initiatives. Data supporting two health behavior theories focused on individuals (Transtheoretical Model and Health Belief Model), and one ecological model (Social Ecological Model) are reviewed and applied to three different pharmacy initiative scenarios. Greater incorporation of behavioral change theories and models may be helpful in creating effective, comprehensive pharmacy initiatives.
Applicability of amino acid derivative reactivity assay (4 mM) for the prediction of skin sensitization by combining multiple alternative methods to evaluate key events
Authors: Imamura Mika , Yamamoto Yusuke , Fujita Masaharu , Wanibuchi Sayaka , Nakashima Natsumi , Kojima Hajime , Ono Atsushi , Kasahara Toshihiko 
Published: January 2022

AbstractThe amino acid derivative reactivity assay (ADRA) is an alternative method for evaluating key event 1 (KE‐1) in the skin sensitization mechanism included in OECD TG442C (OECD, 2021). Recently, we found that ADRA with a 4‐mM test chemical solution had a higher accuracy than the original ADRA (1 mM). However, ADRA (4 mM) has yet to be evaluated using integrated approaches to testing and assessment (IATA), a combination of alternative methods for evaluating KE. In this study, the sensitization potency of three defined approaches (DAs) using ADRA (4 mM) as KE‐1 was predicted and compared with those of two additional ADRAs or direct peptide reactivity assay (DPRA): (i) “2 out of 3” approach, (ii) “3 out of 3” approach, and (iii) integrated testing strategy (ITS). In the hazard identification of chemical sensitizers, the accuracy of human data and local lymph node assay (LLNA) remained almost unchanged among the three approaches evaluated. Potency classifications for sensitization were predicted with the LLNA and human data sets using ITS. The potency classifications for the sensitization potency prediction accuracy of LLNA data using any alternative method were almost unchanged, at approximately 70%, and those with ITS were not significantly different. When ITS was performed using DPRA, the prediction accuracy was approximately 73% for human data, which was similar to that of the LLNA data; however, the accuracy tended to increase for all ADRA methods. In particular, when ITS was performed using ADRA (4 mM), the prediction accuracy was approximately 78%, which proved to be a practical level.
Association of B‐cell lymphoma 2/microRNA‐497 gene expression ratio score with metastasis in patients with colorectal cancer: A propensity‐matched cohort analysis
Authors: Kattan Shahad W. , Hobani Yahya H. , Abubakr Babteen Nouf , Alghamdi Saleh A. , Toraih Eman A. , Ibrahiem Afaf T , Fawzy Manal S. , Faisal Salwa 
Published: January 2022

AbstractBackgroundDeregulated microRNAs (miRs) significantly impact cancer development and progression. Our in silico analysis revealed that miR‐497 and its target gene B‐cell lymphoma‐2 (BCL2) could be related to poor cancer outcomes.PurposeTo investigate the BCL2/miRNA‐497 expression ratio in colorectal cancer (CRC) and explore its association with the clinicopathological characteristics and CRC prognosis.MethodsArchived samples from 106 CRC patients were enrolled. MiR‐497 and BCL2 gene expressions were detected by Taq‐Man Real‐Time quantitative polymerase chain reaction in propensity‐matched metastatic and nonmetastatic cohorts after elimination of confounder bias.ResultsB‐cell lymphoma‐2 gene was upregulated in metastatic samples (median = 1.16, 95%CI = 1.09–1.60) compared to nonmetastatic (median = 1.02, 95%CI = 0.89–1.25, p < 0.001). In contrast, lower levels of miR‐495 were detected in specimens with distant metastasis (median = 0.05, 95%CI = 0.04–0.20) than nonmetastatic samples (median = 0.54, 95%CI = 0.47–0.58, p < 0.001). Estimated BCL2/miR‐497 ratio yielded a significant differential expression between the two cohort groups. Higher scores were observed in metastasis group (median = 1.39, 95%CI = 0.9–1.51) than nonmetastatic patients (median = 0.29, 95%CI = 0.19–0.39, p < 0.001). Receiver operating characteristic curve analysis showed BCL2/miR‐497 ratio score to have the highest predictive accuracy for metastasis at presentation. The area under the curve was 0.90 (95%CI = 0.839–0.964, p < 0.001) at cut‐off of >0.525, with high sensitivity 81.1% (95%CI = 68.6%–89.4%) and specificity 92.5% (95%CI = 82.1%–97.0%). Also, the ratio score was negatively correlated with disease‐free survival (r = −0.676, p < 0.001) and overall survival times (r = −0.650, p < 0.001). Kaplan–Meier curves showed lower survival rates in cohorts with high‐score compared to low‐score patients.ConclusionThe BCL2/miR497 expression ratio is associated with poor CRC prognosis in terms of metastasis and short survival.
The plan formulation method: An empirically validated and clinically useful procedure applied to a clinical case of a patient with a severe personality disorder
Authors: Gazzillo Francesco , Curtis John , Silberschatz George 
Published: January 2022

AbstractThe plan formulation method (PFM) is an empirically validated procedure for identifying a patient's goals for therapy, what is hindering the patient from attaining those goals, and how the patient is likely to work in therapy. In this paper, we employ the PFM to analyze the initial psychotherapy sessions of Geena, a 30‐year‐old outpatient with borderline personality disorder and relational and substance abuse problems. Employing the PFM, we identify a family of pathogenic beliefs (e.g., that she is unlovable and unworthy; that her parents will be hurt if she has satisfying intimate relationships) that Geena sought to disprove in her therapy and explain how she worked with the therapist to do so. We illustrate how the PFM can help the therapist identify what information and what types of interventions will be helpful for a given patient.
Experiential avoidance, uncompassionate self‐responding, and peritraumatic depersonalization/derealization: A novel mediation model for war‐related PTSD symptomatology
Authors: Carvalho Teresa , Pinto‐Gouveia José , Cunha Marina , da Motta Carolina 
Published: January 2022

AbstractObjectiveTo explore a novel model for war‐related posttraumatic stress disorder (PTSD) symptomatology including emotion regulation processes, namely experiential avoidance (EA) and uncompassionate self‐responding (USR), mediating the impact of childhood threat memories, combat exposure distress, combat and noncombat threats, and peritraumatic depersonalization/derealization (PDD) on PTSD symptomatology.MethodA sample of 650 male Portuguese Overseas War veterans filled self‐report instruments.ResultsThe model explained 59% of the variance of PTSD symptomatology. Both EA and USR mediated the effects of noncombat threats and PDD on PTSD. Additionally, EA mediated combat exposure distress and USR mediated childhood threat memories. Combat exposure distress, combat and noncombat threats, and PDD showed direct effects on PTSD symptomatology.ConclusionThe findings help to better understand the relationship between predictive factors of war‐related PTSD in clinical and research settings, providing novel insights on the effects of combat exposure distress, and the different effects of combat and noncombat‐related threats on PTSD.
Moderating role of moral injury in the mental health of adolescent refugees
Authors: McEwen Cassandra , Alisic Eva , Jobson Laura 
Published: January 2022

AbstractObjectiveThis study investigated whether moral injury appraisals moderated the relationships between trauma, postmigration living difficulties, resilience, and mental health outcomes in adolescent refugees.MethodEighty‐five adolescent refugees from a community sample completed an online survey.ResultsA significant interaction was found between moral injury and discrimination for externalizing and posttraumatic stress disorder (PTSD) symptoms; adolescents whom had experienced high levels of discrimination combined with high levels of moral injury had poorer mental health. A significant interaction was found between moral injury and resilience for internalizing symptoms: high levels of resilience appeared to buffer the association between moral injury and internalizing symptoms. Contrary to predictions, stressful life experiences and postmigration living difficulties did not interact significantly with moral injury to predict mental health.ConclusionsDiscrimination may contribute to perpetuating poor mental health in adolescent refugees with high levels of moral injury. Resilience may buffer some of the negative effects of moral injury.
Advances in microfluidic electrochemical fuel cells in recent years
Authors: Ning Hongwei , Zhao Fuqi , Zhou Teng 
Published: January 2022

AbstractMicrofluidic fuel cells (MFFCs) are performing increasingly important roles in production and life, such as electronic products, sensors and real‐time equipment. The microfluidic electrochemical fuel cell (MFEFC) is a significant type of MFFC that has attracted recent global attention. Compared to the other two types, biofuel cells (MFBFCs) and photocatalytic fuel cells (MFPFCs), MFEFCs can be used in a broader range of applications and are less susceptible to external environment. This paper mainly discusses the recent progress of MFEFCs, including catalyst, fuel, electrode, oxidant, design, fabrication, model and performance. The paper summarized the latest research results and practical applications through the above aspects. The authors sincerely hope that this paper will be useful to researchers in the field. Finally, we summarize the article and outline the potential future development and applications of MFEFCs. © 2022 Society of Chemical Industry (SCI).
An efficient and scalable synthesis of Isodesmosine
Authors: Gupta Aikan , Sharma Yogesh , Pawar Ganesh P. , Ashish  , Nihalani Deepak , Chaudhari Vinod D. 
Published: January 2022

AbstractIsodesmosine is 1,2,3,5‐tetrasubstituted pyridinium‐based amino acid substituted with four lysine derivatives found in elastin which is the main component of elastic fiber. Elastin plays a vital role in providing stretchy properties to tissues and body organs. Isodesmsoine is a proven to be useful biomarker for elastin degradation during the progressing stage of chronic obstructive pulmonary disease (COPD) and related diseases. The present work reported an efficient and gram‐scale approach for the synthesis of Isodesmosine, starting from readily available Boc‐Asp‐OtBu using mild reaction conditions.
Synthetic, spectroscopic, and computational investigations of readily accessible 2‐phenyl‐3‐alkylbenzoxazaboroles
Authors: Rathnayaka Chathurika , George Sobiya , Abeysinghe Janaka P. , Lynch Vincent M. , Gross Dustin E. 
Published: January 2022

AbstractWe report several new benzoxazaboroles using 2‐aminophenol or 2‐(alkylamino)phenols and phenylboronic acid derivatives. Bis(benzoxazaborole)s were also synthesized using aminophenols and diboronic acids. Characterization of benzoxazaboroles and bis(benzoxazaborole)s was carried out using 1H NMR, 13C NMR, UV–visible, and fluorescence spectroscopic methods along with mass spectrometry and X‐ray crystallography for structural identification. Computational calculations of benzoxazaboroles and bis(benzoxazaborole)s were utilized to support and add to the experimental results. This includes calculations of conformational energies, bond lengths, HOMO‐LUMO energies, and electrostatic potential maps.
Diamides conformationally restricted with central amino acid: Design, synthesis, and biological activities
Authors: Chen Rui‐Jia , Zhou Cong , Dong Le‐Feng , Feng Ting‐Ting , Wang Gang‐Ao , Wang Jun‐Jie , Gu Yu‐Cheng , Xu Zhi‐Ping , Cheng Jia‐Gao , Shao Xu‐Sheng , Xu Xiao‐Yong , Li Zhong 
Published: January 2022

AbstractDiamide insecticides, represented by chlorantraniliprole (CHL), were widely applied in the control of lepidopteran insects. In efforts to develop bioactive diamides with novel scaffolds, we design and synthesized a series of diamides containing central amino acids to conformationally simulate CHL. Bioassay results indicated that most compounds containing 1‐aminocyclopropane‐1‐carboxylic acid exhibited excellent larvacidal potency against Mythimna separate and Plutella xylostella. After a systematic structure–activity relationship study, 1–23 was identified as a potential insecticidal candidate with LC50 values of 34.920 mg·L−1 against M. separate and 61.992 mg·L−1 on P. xylostella. Finally, molecular docking revealed the possible binding mode of 1–23 with the target protein, ryanodine receptors.
Cognitive dysfunction and white matter hyperintensities in Fabry disease
Authors: Murphy Patrick , Williams Fay , Davagnanam Indran , Chan Edgar , Murphy Elaine , Hughes Derralynn , Quattrocchi Gabriella , Werring David J. , Lachman Robin H. , Cipolotti Lisa 
Published: January 2022

AbstractFabry disease (FD) is an X‐linked lysosomal storage disorder with multi‐system involvement including cerebrovascular disease. Patients with FD also have a high risk of ischaemic stroke and TIA. White matter hyperintensities are common, but their clinical impact on cognition remains uncertain. Previous studies have examined the neuropsychological profile of FD, but have been inconclusive in part due to methodological limitations including small sample sizes. We sought to address these limitations in a case‐control study of 26 patients with Fabry disease with mild to moderate disease symptoms matched with 18 healthy controls for age and premorbid intellectual level. We obtained detailed neuropsychological data and MRI neuroimaging data on the severity of white matter changes. Mood was accounted for as a possible confounder. Our results showed significant compromise of executive functions and information processing speed for the FD group. Error analyses suggested that the compromise of executive functions could not be entirely accounted for by slowed information processing speed. We demonstrated significant correlations between cognitive decline and the overall volume of white matter hyperintensities in the FD group. Our results point to significant compromise of cognition in FD even without stroke or mood difficulties. This suggests that neuropsychological assessment and rehabilitation should be routinely offered to patients with FD.
Three‐Dimensional Bioprinted MR‐Trackable Regenerative Scaffold for Postimplantation Monitoring on T1‐Weighted MRI
Authors: Loai Sadi , Szulc Daniel A. , Cheng Hai‐Ling Margaret 
Published: January 2022

BackgroundA three‐dimensional (3D) bioprinted tissue scaffold is a promising therapeutic that goes beyond providing physical support for tissue regeneration by enabling precise spatial control over scaffold geometry and integration of different materials/cells. Critically important is in vivo confirmation of correct scaffold placement and retention during the initial 24 hours postimplantation, to detect unwanted implant migration.PurposeTo incorporate a safe, efficient MR contrast agent into a bioprinting workflow, and to achieve bright‐contrast scaffold monitoring in vivo postimplantation.Study TypeIn vitro and animal in vivo longitudinal study.Animal ModelTwo female Sprague Dawley rats (~200 g) for labeled and unlabeled scaffold implantation in the subcutaneous dorsal space flanking the vertebral column.Field Strength/SequenceA 7.0 T/T1‐weighted spin echo (SE) sequence and T1 mapping using turbo SE with variable repetition times (TRs).AssessmentCell viability and proliferation were assessed over 2 weeks after labeling bioprinted gelatin/alginate scaffolds with MnPNH2 (0.5 mM, 24 hours). In vitro MRI was performed 0, 12, and 24 hours postlabeling in nine labeled and three unlabeled (control) scaffolds to monitor T1 evolution. In vivo MRI was performed immediately and 24 hours postimplantation to assess T1. Acute inflammation near surgical site was monitored in one rat to 3 days.Statistical TestsOne‐way analysis of variance with Tukey–Kramer post hoc analysis (P < 0.01).ResultsCell viability was unaffected by bioprinting/labeling: viability exceeded 90% in all scaffolds after 1 week. In vitro T1's were significantly lower in labeled scaffolds compared to control (207 msec vs. 2257 msec) immediately postlabeling and 24 hours later (1227 msec vs. 2257 msec). In vivo T1's were significantly different (243.6 msec vs. 2414.6 msec) immediately postimplantation, and no differences emerged compared to respective in vitro control/labeled counterparts. The 24‐hours imaging and gross pathology confirmed migration of scaffolds beyond the imaging field.Data ConclusionWe report an MR‐detectable, cell‐compatible bioprinted scaffold, utilizing a T1‐weighting contrast agent for high‐resolution, postimplantation scaffold tracking.Evidence Level2Technical EfficacyStage 1