bluuebunny/crossref_metadata_2025_split huggingface dataset:
Special issue “The advance of solid tumor research in China”: Prediction of Sunitinib efficacy using computed tomography in patients with pancreatic neuroendocrine tumors
Authors: Chen Luohai , Wang Wei , Jin Kaizhou , Yuan Bing , Tan Huangying , Sun Jian , Guo Yu , Luo Yanji , Feng Shi‐Ting , Yu Xianjun , Chen Min‐Hu , Chen Jie 
Published: September 2022

AbstractClinically effective methods to predict the efficacy of sunitinib, for patients with metastatic or locally advanced pancreatic neuroendocrine tumors (panNET) are scarce, making precision treatment difficult. This study aimed to develop and validate a computed tomography (CT)‐based method to predict the efficacy of sunitinib in patients with panNET. Pretreatment CT images of 171 lesions from 38 patients with panNET were included. CT value ratio (CT value of tumor/CT value of abdominal aorta from the same patient) and radiomics features were extracted for model development. Receiver operating curve (ROC) with area under the curve (AUC) and decision curve analysis (DCA) were used to evaluate the proposed model. Tumor shrinkage of >10% at first follow‐up after sunitinib treatment was significantly associated with longer progression‐free survival (PFS; P < .001) and was used as the major treatment outcome. The CT value ratio could predict tumor shrinkage with AUC of 0.759 (95% confidence interval [CI], 0.685‐0.833). We then developed a radiomics signature, which showed significantly higher AUC in training (0.915; 95% CI, 0.866‐0.964) and validation (0.770; 95% CI, 0.584‐0.956) sets than CT value ratio. DCA also confirmed the clinical utility of the model. Subgroup analysis showed that this radiomics signature had a high accuracy in predicting tumor shrinkage both for primary and metastatic tumors, and for treatment‐naive and pretreated tumors. Survival analysis showed that radiomics signature correlated with PFS (P = .020). The proposed radiomics‐based model accurately predicted tumor shrinkage and PFS in patients with panNET receiving sunitinib and may help select patients suitable for sunitinib treatment.
Optimal water distribution model of canals considering the workload of managers
Authors: Fan Yu , Chen Haorui , Gao Zhanyi , Wang Yunhui , Xu Jianhui 
Published: September 2022

AbstractThe optimal operation of water distribution systems is an important research area for the modernization of irrigation schemes. In this paper, an improved 0–1 programming model is developed. This model has three objectives: minimum time of water distribution, minimum spacing of tertiary canals in a group, and the minimum difference of water distribution duration among tertiary canals in the group. The study results show that with the conventional model, 0–1 programming model and improved 0–1 programming model, the durations for the three models are 159.09, 140.50 and 141.07 h, respectively. The working distances are 44.8, 185.5 and 60.6 km. Compared with the conventional model, the lower canals of the improved 0–1 model are all large flow rate operations, while the conventional model inevitably has small flow rate operations, and the improved 0–1 model greatly reduces the duration of water distribution. Compared with the 0–1 model, the improved 0–1 model divides the adjacent canals into a group as much as possible, and the canals between groups start and end operations at the same time as much as possible, so the improved 0–1 model shortens the working distance of the staff and makes it easy for canal managers to operate canals.
Surface modifications to promote the osteoconductivity of ultra‐high‐molecular‐weight‐polyethylene fabrics for a novel biomimetic artificial disc prosthesis: An in vitro study
Authors: Jacobs Celien A. M. , Cramer Esther E. A. , Dias Aylvin A. , Smelt Harold , Hofmann Sandra , Ito Keita 
Published: September 2022

AbstractA novel biomimetic artificial intervertebral disc (bioAID) for the cervical spine was developed, containing a hydrogel core representing the nucleus pulposus, an UHMWPE fiber jacket as annulus fibrosis, and titanium endplates with pins for mechanical fixation. Osseointegration of the UHMWPE fibers to adjacent bone structures is required to achieve proper biomimetic behavior and to provide long‐term stability. Therefore, the aim of this study was to assess the osteoconductivity of several surface modifications of UHMWPE fabrics, 2D weft‐knitted, using non‐treated UHMWPE fibers (N), plasma treated UHMWPE fibers (PT), 10% hydroxy apatite (HA) loaded UHMWPE fibers (10%HA), plasma treated 10%HA UHMWPE fibers (PT‐10%HA), 15%HA loaded UHMWPE fibers (15%HA) and plasma treated 15%HA UHMWPE fibers (PT‐15%HA). Scanning electron microscopy (SEM) was used for surface characterization. Biological effects were assessed by evaluating initial cell attachment (SEM, DNA content), metabolic activity (PrestoBlue assay), proliferation, differentiation (alkaline phosphatase activity) and mineralization (energy dispersive x‐ray, EDX analysis) using human bone marrow stromal cells. Plasma treated samples showed increased initial cell attachment, indicating the importance of hydrophilicity for cell attachment. However, incorporation only of HA or plasma treatment alone was not sufficient to result in upregulated alkaline phosphatase activity (ALP) activity. Combining HA loaded fibers with plasma treatment showed a combined effect, leading to increased cell attachment and upregulated ALP activity. Based on these results, combination of HA loaded UHMWPE fibers and plasma treatment provided the most promising fabric surface for facilitating bone ingrowth.
Emerging role of mitochondria in response to HBV infection
Authors: Lin Caorui , Ou Qishui 
Published: September 2022

AbstractHepatitis B is a major global health problem that potentially life‐threatening liver infection caused by the hepatitis B virus (HBV), which can lead to death due to liver cirrhosis and hepatocellular carcinoma (HCC). A considerable of research has demonstrated that mitochondrial dysfunction exists in patients with HBV infection, indicating that there is clinical relation between HBV infection and mitochondrial alterations. To explore the complex interplay between the functions of mitochondria and HBV infection in greater depth, we systematically summarized these mitochondrial alterations due to HBV infection in recent years. The liver is the central organ of metabolism that is a mitochondria‐rich tissue and represents strong defense and regeneration capabilities in the body. Infested cells and their microenvironment must upregulate energy production for proliferation, growth, and effector functions to restrain the damage imposed by HBV. The changes in metabolic pathways caused by HBV infection are nothing more than those in the cytoplasm and mitochondria. Thus, this article brings into focus the effects of novel reprogramming of inner and outer mitochondria on HBV infection and then derives novel insights and new approaches for HBV diagnosis and therapy.
Response of mixed bacterial culture towards dibenzothiophene desulfurization under the influence of surfactants and microscopically (SEM and TEM) characterized magnetic Fe3O4 nanoparticles
Authors: Khan Javed , Ali Muhammad Ishtiaq , Jamal Asif , Ahmad Mushtaq , Achakzai Jahangir Khan , Zafar Muhammad 
Published: September 2022

AbstractExcessive emission of sulfur dioxides from the combustion of coal and other fossil fuels for thermal and industrial purposes has been associated with serious environmental hazards. Biodesulfisation (BDS) can be an effective approach for reducing the impact of toxic gases to its inbuilt operational feasibility under ambient environmental conditions. In the present research, two strategies for BDS of a standard organosulfur compound such as dibenzothiophene (DBT) were investigated under laboratory conditions. In the first treatment, the role of different surfactants such as Tween‐20, Tween‐80, SDS, and EDTA on the desulfurization of DBT was investigated by the application of bacterial consortium IQMJ‐5. In the second treatment, Iron oxidenanoparticles were synthesized and immobilized on the surface of bacteria cells. Shake flask experiments were conducted with immobilized cells, surfactant amended immobilized cells, and control or noncoated cells. Among different surfactant treatments, Tween‐80 was found to be the most effective surfactant, showing maximum desulfurization activity at a concentration of 5 g/L. The transmission electron microscopy and X‐ray diffraction analysis indicated that produced nanoparticles were spherical in shape with a size of about 46 nm and had a stoichiometric ratio of 55.85% and 44.15% between O and Fe, respectively. The nanoparticle treatment enhanced the DBT desulfurization process up to 11.37% as compared to the control, specifically when immobilized cells were used. Therefore, it was concluded that nanoparticles treatments with immobilization of the bacterial cells enhanced the desulfurization rate of DBT under ambient reaction conditions and provide a sustainable alternative for commercial coal BDS.
Adolescent and young adult preferences for financial incentives to support adherence to antiretroviral therapy in Kenya: a mixed methods study
Authors: Eshun‐Wilson Ingrid , Akama Eliud , Adhiambo Fridah , Kwena Zachary , Oketch Bertha , Obatsa Sarah , Iguna Sarah , Kulzer Jayne L. , Nyanga James , Nyandieka Everlyne , Scheve Ally , Geng Elvin H. , Bukusi Elizabeth A. , Abuogi Lisa 
Published: September 2022

AbstractIntroductionTo develop a patient‐centred financial incentive delivery strategy to improve antiretroviral treatment adherence in adolescents and young adults (AYA) living with HIV in Kisumu, Kenya, we conducted a mixed methods study exploring preferences.MethodsA discrete choice experiment (DCE) and focus group discussion (FGD) were conducted simultaneously to identify preferences for five incentive delivery strategy features: value, eligibility, recipient, format and disbursement frequency. We used consecutive sampling to recruit AYA (14–24 years) living with HIV attending three health facilities in Kisumu, Kenya. We calculated mean preferences, willingness to trade, latent class membership and predictors of latent class membership. The FGD explored preferred incentive features, and, after deductive and inductive coding, qualitative findings were triangulated with DCE results.ResultsTwo hundred and seven AYA living with HIV (46% 14–17 years, 54% 18–24 years; 33% male sex, 89% viral load <50 copies/ml) were recruited to the study (28 October–16 November 2020). Two distinct preference phenotypes emerged from the DCE analysis (N = 199), 44.8% of the population fell into an “immediate reward” group, who wanted higher value cash or mobile money distributed at each clinic visit, and 55.2% fell into a “moderate spender” group, who were willing to accept lower value incentives in the form of cash or shopping vouchers, and accrued payments. The immediate reward group were willing to trade up to 200 Kenyan Shillings (KSH)—approximately 2 US dollars (USD)—of their 500 KSH (∼5 USD) incentive to get monthly as opposed to accrued yearly payments. The strongest predictor of latent class membership was age (RR 1.45; 95% CI: 1.08–1.95; p = 0.006). Qualitative data highlighted the unique needs of those attending boarding school and confirmed an overwhelming preference for cash incentives which appeared to provide the greatest versatility for use.ConclusionsProviding small financial incentives as cash was well‐aligned with AYA preferences in this setting. AYA should additionally be offered a choice of other incentive delivery features (such as mobile money, recipient and disbursement frequency) to optimally align with the specific needs of their age group and life stage.
Improving medicine information on discharge summaries through implementation of a reconciliation‐based intervention
Authors: Nguyen Anna , Gibson Stephanie , Wembridge Paul 
Published: September 2022

AbstractThe handover of medication‐related information at the point of discharge often occurs via the discharge summary (DS), although these frequently contain errors. We aimed to investigate whether an intern pharmacist reviewing the medication details in discharge summaries (DSs), reconciling them with the discharge prescription and pointing out any discrepancies with the medical staff would reduce the rate of medication errors. The intervention was retrospectively reviewed by comparing medication information on the DS with the discharge prescription (considered the ‘source of truth’). Error rates on the DS were compared to a control group of patients discharged over a different 2‐week period from the same ward. A modified APINCH (Antimicrobials, Potassium and other electrolytes, Insulin, Narcotics and other sedatives, Chemotherapeutic agents, Heparin and other anticoagulants, Systems) classification system was used to identify high‐risk errors. The time taken to perform the intervention was measured and details of any recommendations collected. The study included 22 intervention patients and 31 control patients. Patients who received the intervention were less likely to have one or more medication errors on their DS (any: 4% vs 84%, p < 0.01; high‐risk: 0% vs 29%, p < 0.01). The intern pharmacist made a total of 77 recommendations during the intervention. Six recommendations (8%) related to high‐risk medications. The median time required to undertake the first review was 4 min, and the second review took 1 min. In conclusion, we found a reconciliation‐based intervention involving an intern pharmacist could reduce the rate of medication errors on DSs.
NSABP FC‐6: Surgical conversion rate in colorectal cancer patients with unresectable, KRAS wild‐type liver metastases receiving mFOLFOX7 plus cetuximab
Authors: Wagman Lawrence D. , Geller David A. , Jacobs Samuel A. , Petrelli Nicholas J. , Allegra Carmen J. , Lipchik Corey , Pogue‐Geile Katherine L. , Srinivasan Ashok , Wang Ying , O'Connell Michael J. ,   NSABP FC‐6 Study Group
Published: September 2022

AbstractPurposeThis study sought to determine the R0 resection rate in KRAS wild‐type (WT), liver‐only metastatic colorectal cancer (CRC) patients initially identified as having unresectable disease who were treated with FOLFOX7 plus cetuximab. Exploratory molecular analyses were undertaken before and after treatment.MethodsTwenty patients were enrolled. None had prior adjuvant chemotherapy. Cetuximab was added to a FOLFOX7 backbone and administered at 500 mg/m2 every 14 days with dose reductions to 400 and 300 mg/m2 in the event of toxicity. In the absence of toxicity, dose‐escalations to 600, 700, and 800 mg/m2 were allowed. The mean dose of cetuximab (mg/m2/week) throughout the study was 289 mg/m2. Paired samples were collected for correlative studies, where feasible.ResultsWe assessed the conversion rates from unresectable to resectable in hepatic‐only, KRAS exon 2 WT mCRC. Seventeen of 20 patients undergoing chemotherapy were considered resectable by imaging criteria; R0 resection was achieved in 15/20 patients. Molecular profiling revealed heterogeneity between patients at the gene‐expression, pathway signaling, and immune‐profile levels.ConclusionsAlthough 15/20 (75%) converted to R0 resection, by 2 years, 10/15 R0 resections had recurred. Therefore, chemotherapy plus cetuximab is of limited long‐term benefit in this setting. ctDNA analysis may guide additional therapy including immunotherapy.
Ultrafast Electron Dynamics and Optical Interference Tomography of Laser Excited Steel
Authors: Fuentes‐Edfuf Yasser , Garcia‐Lechuga Mario , Solis Javier , Siegel Jan 
Published: September 2022

AbstractFemtosecond laser machining of materials has transformed into a mature high‐precision technology, giving access to a wide range of applications. Yet, for a complete exploitation of its full potential, a detailed knowledge of the complex laser–matter interaction processes is required. For the case of the application‐relevant material steel, a complete study of the electron dynamics and material transformation upon single laser pulse irradiation (800 nm, 120 fs) is reported. Detailed analysis of the obtained time‐ and fluence‐dependent reflectivity map reveals that ultrafast electron heating during the pulse is directly followed by energy transfer to the lattice within a few picoseconds, reaching fluence‐dependent peak temperatures from below melting threshold to above the boiling point. Moreover, an innovative approach to obtain the ultrafast‐evolving 3D structure of a femtosecond laser excited material is reported, unraveling the dynamics of complex processes as melting, ablation, and solidification. Combined with modeling, the evolving optical properties, multilayer structure, and expansion velocities can be precisely determined. The information obtained from this study will contribute to further increase the achievable precision and wealth of structures that can be produced by designing efficient pulsed energy deposition schemes for selective re‐excitation of the material.
Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
Authors: Miller James Coleman , Satheesh Babu Adhini Kuppuswamy , Petersen Chrissa , Wankhade Umesh D. , Robeson Michael S. , Putich Madison Nicole , Mueller Jennifer Ellen , O'Farrell Aubrey Sarah , Cho Jae Min , Chintapalli Sree V. , Jalili Thunder , Symons John David , Anandh Babu Pon Velayutham 
Published: September 2022

ScopeMetabolic syndrome (MetS) alters the gut microbial ecology and increases the risk of cardiovascular disease. This study investigates whether strawberry consumption reduces vascular complications in an animal model of MetS and identifies whether this effect is associated with changes in the composition of gut microbes.Methods and resultsSeven‐week‐old male mice consume diets with 10% (C) or 60% kcal from fat (high‐fat diet fed mice; HF) for 12 weeks and subgroups are fed a 2.35% freeze‐dried strawberry supplemented diet (C+SB or HF+SB). This nutritional dose is equivalent to ≈160 g of strawberry. After 12 weeks treatment, vascular inflammation is enhanced in HF versus C mice as shown by an increased monocyte binding to vasculature, elevated serum chemokines, and increased mRNA expression of inflammatory molecules. However, strawberry supplementation suppresses vascular inflammation in HF+SB versus HF mice. Metabolic variables, blood pressure, and indices of vascular function were similar among the groups. Further, the abundance of opportunistic microbe is decreased in HF+SB. Importantly, circulating chemokines are positively associated with opportunistic microbes and negatively associated with the commensal microbes (Bifidobacterium and Facalibaculum).ConclusionDietary strawberry decreases the abundance of opportunistic microbe and this is associated with a decrease in vascular inflammation resulting from MetS.
Orally Administered Xylo‐Oligosaccharides (XOS) Ameliorates Diarrhea Symptoms in Mice via Intestinal Barrier Improvement and Gut Microbiota Modulation
Authors: Tong Yanjun , Wang Qinyue , Zhang Jieyu , Yang Ruijin 
Published: September 2022

AbstractXylo‐oligosaccharides (XOS) has a bidirectional regulatory effect, and can be fermented by gut microbiota. This study aims to investigate how XOS alleviates Folium Sennae extracts induced diarrhea in mice. KM mice are given different concentration XOS for 3 weeks, and then Folium Sennae (Senna alexandrina Mill) extracts solutions (0.8 g mL−1) are given to establish diarrhea model. The results show that doses of XOS at 0.25 mg g−1 BW day−1 and higher could alleviate diarrhea symptoms by decreasing the disease activity indexes, down‐regulating pro‐inflammatory factors, up‐regulating anti‐inflammatory factor, and suppressing the intestinal permeability in colon tissues. XOS also regulates the composition of gut microbiota via increasing the abundance Prevotellaceae, Ruminococcus, and Bifidobacterium. The results suggest that the dietary supplementation XOS could be a more effective choice to prevent and alleviate diarrhea.
ADEPT: Accurate Diffusion Echo‐Planar imaging with multi‐contrast shoTs
Authors: Shafieizargar Banafshe , Jeurissen Ben , Poot Dirk H. J. , Klein Stefan , Van Audekerke Johan , Verhoye Marleen , den Dekker Arnold J. , Sijbers Jan 
Published: September 2022

PurposeTo introduce a novel imaging and parameter estimation framework for accurate multi‐shot diffusion MRI.Theory and MethodsWe propose a new framework called ADEPT (Accurate Diffusion Echo‐Planar imaging with multi‐contrast shoTs) that enables fast diffusion MRI by allowing diffusion contrast settings to change between shots in a multi‐shot EPI acquisition (i.e., intra‐scan modulation). The framework estimates diffusion parameter maps directly from the acquired intra‐scan modulated k‐space data, while simultaneously accounting for shot‐to‐shot phase inconsistencies. The performance of the estimation framework is evaluated using Monte Carlo simulation studies and in‐vivo experiments and compared to that of reference methods that rely on parallel imaging for shot‐to‐shot phase correction.ResultsSimulation and real‐data experiments show that ADEPT yields more accurate and more precise estimates of the diffusion metrics in multi‐shot EPI data in comparison with the reference methods.ConclusionADEPT allows fast multi‐shot EPI diffusion MRI without significantly degrading the accuracy and precision of the estimated diffusion maps.
Gadolinium retention in the ischemic cerebrum: Implications for pain, neuron loss, and neurological deficits
Authors: Huang Xin‐Xin , Jiang Run‐Hao , Xu Xiao‐Quan , Wang Wei , Sun Yu‐Qin , Li Lei , Shi Hai‐Bin , Liu Sheng 
Published: September 2022

PurposeTo investigate the effects of gadolinium (Gd) retention of macrocyclic (gadobutrol) or linear (gadopentetate) Gd‐based contrast agents (GBCAs) on neuron loss, neurological deficits, and sensory behavior in mice with or without stroke.MethodsNinety C57BL/6 mice underwent sham (n = 36) or transient middle cerebral artery occlusion (tMCAO) (n = 54) surgery and then received intraperitoneal injections of 5.0 mmol/kg gadobutrol, 5.0 mmol/kg gadopentetate or saline (10 ml/kg/administration) per day for 3 consecutive days. The Gd concentration in the ischemic cerebrum was quantified by inductively coupled plasma mass spectrometry on Day 1 and Day 28 after the last injection (post‐injection, p. i.). Neuron loss, glia activation and neurological deficits were assessed on Day 1 and 28 p. i. Sensory behavior was also assessed on Day 28 p. i.ResultsGd concentrations were higher in the brains of tMCAO mice than in those of sham mice on Days 1 p. i. of both GBCAs (gadobutrol, p < 0.05; gadopentetate, p < 0.001) and 28 p. i of gadopentetate. (p < 0.001). Sham or tMCAO mice injected with GBCAs showed no significant difference in neuron loss, glia activation, neurological deficits, brain atrophy, or hippocampus‐dependent memory (all p > 0.05). Both gadobutrol and gadopentetate induced mechanical and heat hyperalgesia in sham mice (all p < 0.05). However, mechanical hyperalgesia but rather heat hyperalgesia was found in tMCAO mice with the highest force tested (1.0 g) and statistically significant in both paws (right and left) with gadopentetate only (p < 0.05).ConclusionsNeither gadobutrol nor gadopentetate worsened neuron loss, glia activation, brain atrophy, neurological deficits, or hippocampus‐dependent memory after tMCAO. However, GBCA administration induced mechanical hyperalgesia in sham and tMCAO mice although in the same level, which may be an important consideration for patients with central post‐stroke pain and those who are sensitive to pain and about to receive multiple GBCA administrations.