bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac amyloidosis: Innovations in diagnosis and treatment
Authors: Castiglione Vincenzo , Montuoro Sabrina , Orlando Giulia , Aimo Alberto , Vergaro Giuseppe , Emdin Michele 
Published: February 2025

Abstract
Cardiac amyloidosis (CA) is a progressive, underdiagnosed condition caused by the deposition of misfolded proteins in the myocardium, forming amyloid fibrils that impair cardiac structure and function. This review highlights recent advances in the diagnosis and treatment of amyloid light-chain (AL) and transthyretin (ATTR) CA, which globally account for most cases of CA. Novel diagnostic tools, including artificial intelligence-enhanced analysis and advanced imaging modalities like positron emission tomography with amyloid-specific tracers, might improve detection rates and diagnostic accuracy to enable non-invasive subtype differentiation. Furthermore, many innovative treatments are being investigated. For AL-CA, anti-fibril therapies are showing promising results, complementing traditional chemotherapy and autologous stem cell transplantation. In ATTR-CA, gene silencing and anti-fibril therapies are being tested in clinical trials and hold promise of halting disease progression and reducing amyloid deposits, respectively.
Genetics in arrhythmogenic cardiomyopathies: where are we now and where are we heading to?
Authors: Mazzanti Andrea , Kukavica Deni , Trancuccio Alessandro , Scilabra Gabriele G , Coppini Lucia , Pergola Valerio , Tempo Erika , Pili Gianluca , Napolitano Carlo , Priori Silvia G 
Published: February 2025

Abstract
Advances in understanding the genetic architecture and novel imaging techniques have profoundly impacted research on arrhythmogenic right ventricular cardiomyopathy (ARVC). As knowledge of ARVC has evolved, so has its classification: originally termed “arrhythmogenic right ventricular dysplasia”, it was later broadened to “arrhythmogenic cardiomyopathy” (ACM) to include left ventricular forms. However, the 2023 European Society of Cardiology guidelines advocate reintroducing ARVC for fibro-fatty right ventricular disease and adopting “non-dilated left ventricular cardiomyopathy” for left-sided phenotypes previously labelled as ACM variants. Genetic testing has become critical in ARVC diagnosis, particularly for identifying mutations in desmosomal genes (e.g., PKP2, PKP2, PKP2, PKP2, PKP2), which are the primary genetic contributors to ARVC and inform family screening and diagnostic decisions. Recent expert consensus confirmed that only PKP2, PKP2, and PKP2 gene mutations among non-desmosomal genes had sufficient evidence to suggest a causative relationship. While genotype-specific risk assessment models are being developed, at present, genetic background does not represent an independent risk factor for patients with ARVC. Novel gene therapies, particularly AAV-mediated PKP2 gene replacement, have recently been demonstrated to be useful in reversing ARVC phenotypes in preclinical models. FDA-approved trials are currently evaluating PKP2-targeted therapies, and CRISPR/Cas9 methods are being explored for PKP2-R14del mutations. Overall, current evidence supports distinct gene-specific manifestations within ARVC, aligning clinical phenotypes with specific genetic variants. This progress points to a future in which risk stratification and management are personalized through gene- and mutation-specific approaches, advancing the potential for precision medicine in ARVC care.
Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure Results from the SOLVE-CRT Randomised Sub-study
Authors: Montemerlo Elisabetta , Rovaris Giovanni , Singh Jagmeet P , Rinaldi Christopher A , Sanders Prashanthan , Kubo Spencer H , James Simon , Niazi Imran K , Betts Tim R , Aziz Emad , Biffi Mauro , Zaidi Amir , Alison Jeffrey , Auricchio Angelo , Gold Michael R , Lindenfeld JoAnn , Walsh Mary Norine , Butter Christian 
Published: February 2025

Background
Despite the well-established role of CRT in heart failure, major limitations of CRT are an occasional incidence of unsuccessful coronary sinus (CS) lead placement, one third non-responders in conventional CRT patients and higher complications risk in CRT upgrade procedures. The WiSE® Wireless Stimulation Endocardial) CRT System is designed to overcome these limitations. Prior non-randomised studies with the WiSE® CRT System have shown high implant success rates and improvement in LV remodeling and heart failure symptoms.

Objectives
Pivotal study to assess the safety and effectiveness of the WiSE® CRT System in an international, randomized, two-arm, double blinded, prospective study (randomized part only).

Method
99 Patients with indication for CRT and previously failed CRT implant, considered as high-risk upgrade to conventional CRT, or non-responders to conventional CRT underwent device implantation and were then randomised into treatment (47 pts, System ON) and control (52 pts System OFF) groups for 6 months. Primary efficacy endpoints were change in LVESV, LVEDV, LVEF and QRS over 6 months in blinded Echo and ECG core lab analysis.

Results
Mean ΔLVESV (%) -14.6 (-19.6, -9.6); mean ΔLVEDV (%) -8.1 (-11.9, -4.3) and mean ΔQRS (ms) -41.9 (-50.1, -33.7) in the treatment group were significantly lower/shorter than mean ΔLVESV (%) -5.2 (-10.7, 0.2); mean ΔLVEDV (%) -3.0 (-7.0, 1.0) and mean ΔQRS (ms) -1.7 (-7.1,3.8) in the control group, p=0.005; p=0.027 and p=0.001, 95% CI. Mean ΔLVEF (%) 5.4 (3.2, 7.7) in the treatment group increased significantly compared to control group ΔLVEF (%) 2.4 (0.2, 4.5), p=0.048. 8 of 99 pts were attempted from WiSE CRT implant.

Conclusion
This randomized sub-study of the pivotal SOLVE-CRT trial demonstrates that leadless, ultrasound-based endocardial pacing for heart failure is feasible and efficacious showing evidence of left ventricular remodelling and electrical response after 6 months.Figure 1WISE® CRT System Figure 2Efficacy entire randomised population
Magnetic extraction for rapid assessment of low-level Escherichia coli and Salmonella contamination in complex food matrices
Authors: Sharief Saad Asadullah , Caliskan-Aydogan Oznur , Alocilja Evangelyn 
Published: February 2025

Abstract
Foodborne illnesses cause numerous hospitalizations worldwide, making rapid detection of causative pathogens critical for outbreak prevention. Enrichment of pathogens is often required to increase the minimum bacterial count before detection. Traditional magnetic nanoparticle (MNP)-based extraction methods are limited by the costs associated with recognition ligands and cold-storage requirements. This study presents the use of glycan-coated magnetic nanoparticles (gMNPs), synthesized via a simple one-pot method, for the rapid concentration and extraction of Escherichia coli and Salmonella enterica serovar Enteritidis. The efficiency was measured using the concentration factor (CF), which was used to compare the viability of cells cultured with gMNPs with that of the controls. High CF values were achieved in large volumes, with values of 5.2 (±1.0) for E. coli and 3 (±1.3) for S. Enteritidis. Transmission electron microscopy and confocal laser microscopy confirmed gMNPs binding to bacterial cells in buffer solution and food matrices. The gMNPs effectively extracted cells in varied pH environments, indicating their potential for use in different foods. S. Enteritidis and E. coli were successfully extracted from melons, cucumber, raw chicken, and lettuce samples despite the presence of natural microbiota. Among the S. Enteritidis-inoculated food samples, the highest CF was observed in melons (5.57±2.26), followed by cucumbers (2.94±2.02), chicken (2.24±1.05), and lettuce (1.75±0.56). Real-time quantitative polymerase chain reaction (qPCR) confirmed the magnetic extraction, with the gMNP-qPCR system enabling rapid assessment of low pathogen contamination in complex food matrices. The quantification cycle (Cq) ratio, inversely related to the DNA concentration, corroborated the CF results, with the lowest ratio in melons (0.85±0.03), followed by cucumber (0.89±0.07), chicken (0.98±0.01), and lettuce (0.97±0.009). The entire extraction and qPCR detection process can be completed in less than 4 h.
Successful Aging with Innovations in Technology and Housing
Authors: Jenkins Melinda L , Barberio Judith 
Published: February 2025

Abstract
Emphasizing personal autonomy and community support, this paper presents three independent housing models in which older adults may be empowered to age successfully at home and engage in self-care and shared community care with innovations in technologies, financing, and nurse care coordination. Cooperative communities, naturally occurring retirement communities, and virtual villages are described and mapped to the AARP “age friendly” Livability Index, stakeholders, and partners. Helpful neighborhood services are mapped to innovative technologies that will enable them. On-site nurse-led Wellness Hubs are proposed to bridge from self-care in the community to established health care systems. Medicare payment for remote care, care coordination, and transitional care, as well as home-based care for dementia, will support this evolution toward what matters most to the growing population of older Americans.
Recent earthquakes on unmapped faults highlight hidden seismic hazards within the Golden Triangle region of Laos, Thailand, and Myanmar
Authors: Sethanant I , Nissen E , Bergman E , Oliva S J , Pousse-Beltran L , Karasözen E , Pananont P 
Published: February 2025

Summary
In the past decade, six Mw ≥5.5 earthquakes struck the mountainous Golden Triangle region (Laos, Thailand, Myanmar) of the southeast India-Eurasia collision zone. The largest of them, the 2019 Mw 6.2 Sainyabuli earthquake in western Laos, shook river communities, dams, and a UNESCO World Heritage Site, prompting a need to understand regional earthquake potential. We used Interferometric Synthetic Aperture Radar (InSAR) data and modelling to solve for the 2019 mainshock source parameters, revealing right-lateral strike-slip along a 24 km-long NNW-trending fault which has limited topographic expression and was previously unmapped. InSAR modelling of its largest (Mw 5.5) aftershock in 2021 revealed a 7 km-long splay fault, also previously unrecognized. The 2022 Mw 5.9 Keng Tung earthquake in the northern Golden Triangle also ruptured an unknown, NW-trending right-lateral fault conjugate to longer, NE-trending faults nearby. Collectively, this shows that the region contains faults which are little evident in global digital topography and/or obscured by vegetation but long enough to generate sizeable earthquakes that should be accounted for in seismic hazard assessments. We relocated well-recorded aftershocks and other background seismicity (1978–2023) from across the Golden Triangle using the mloc software. Calibrated hypocenters span focal depths of 5–24 km and are distributed away from the main InSAR-modelled fault traces, another indication of fault structural immaturity. For the three 2019–2022 InSAR-constrained events, we also obtained moment tensor solutions from regional seismic waveform inversion. InSAR-derived peak slip depths and seismological centroid depths are mostly shallow (3–5 km), while focal depths are generally located in areas of low coseismic slip near the bottom of InSAR model faults. More broadly, we estimate a regional seismogenic thickness of ∼17 km (the 90% seismicity cut-off depth), a crucial parameter for seismic hazard calculations and building codes. Our integration of remote-sensing and seismologic analyses could be a blueprint for assessing earthquake potential of other regions with sparse instrumentation and limited topographic fault expression.
Totally endoscopic aortic valve replacement with concomitant septal myectomy
Authors: Kim Sahri , Yoo Jae Suk 
Published: February 2025

Abstract
Left ventricular outflow tract obstruction may become apparent after successful aortic valve replacement for severe aortic stenosis, necessitating both aortic valve replacement and septal myectomy. Despite significant advancements in minimally invasive surgery, the current literature on concurrent minimally invasive cardiac procedures is limited due to the varying optimal exposures required for each procedure. In this context, we present a case of aortic valve replacement with concomitant septal myectomy using a minimally invasive, totally endoscopic approach.
Global profit shifting of multinational companies: Evidence from country-by-country reporting micro data
Authors: Fuest Clemens , Greil Stefan , Hugger Felix , Neumeier Florian 
Published: February 2025

Abstract
We use micro data from country-by-country reports of more than 3 600 multinational companies to analyze global profit shifting to avoid taxes. Unlike other data sets, country-by-country reports provide detailed information about the global economic activities of multinational companies, including those in tax haven countries. We find that these companies reduce their tax burden by €39 billion per year by shifting profits to low-tax countries. Extrapolating our results to the universe of large MNEs indicates a global loss in corporate tax revenues of €162 billion per year (12% of their overall tax payments). We show that taking into account non-linearities in profit shifting and subsidiaries reporting zero profits is key for accurately estimating profit shifting.
Preliminary Validity of a Daily Functional Status Pain Assessment Tool
Authors: Smith Wally R , Qayyum Rehan , Ulbing Alexandra , Guy Margaret S , Sop Daniel M , Zhang Yue May 
Published: February 2025

Abstract

Objectives
Readiness for discharge for a sickle cell disease vaso-occlusive crisis is dictated by factors far beyond pain control, including physical function/activity. We therefore designed and tested a functional status-based pain assessment questionnaire in SCD patients hospitalized with vaso-occlusive crises.

Methods
Sickle cell disease patients on a preselected nursing unit rated 10 draft Functional status-Based Pain Assessment items of activities of daily living on a 5 point Likert scale (0-5) from “very easy” to “very difficult” daily on each day of their admission until discharge, at approximately the same time. Concurrently, they reported Numeric Rating Scale (0-10) pain intensity. For validation, we used exploratory factor analysis, confirmatory factor analysis, and item response theory analysis.

Results and Discussion
We analyzed 503 observations from 175 admissions of 88 patients. Half were female, the mean age was 32.1+/- 11.8 years, and the mean length of stay was 7.1 +/-6.9 days. The mean Numeric Rating Scale (6.8 ± 1.9) was inversely correlated with the mean Functional Status-based Pain Assessment (0-50) score (27 ± 8.0, r= -0.4342, p &lt;.0001). Functional Status-based Pain Assessment item means ranged from 2.1 to 3.3. Cronbach’s alpha was 0.91. Exploratory factor analysis showed that all Functional Status-based Pain Assessment items loaded on a single factor. Confirmatory factor analysis found adequate convergent and discriminant validity and showed strong fit of the model to the data. Item response theory analysis showed item discrimination ranging from 0.56 to 4.1, while difficulty ranged from -2.8 to 7.5.

Conclusion
The Functional Status-based Pain Assessment shows strong correlation with daily Numeric Rating Scale, is multidimensional, and demonstrates strong construct validity. It may improve assessment of sickle cell disease vaso-occlusive crisis pain and may enhance vaso-occlusive crisis discharge discussions.
‘And Then They Will Fast on That Day’ (Mark 2:20): The Absent Bridegroom and the Day of Atonement in Early Christianity
Authors: Botner Max 
Published: February 2025

Abstract
Markan interpreters agree that the fulcrum of the first controversy series (Mark 2:1–3:6) is a logion that underscores Jesus’ absence from the community he founded: ‘The days will come when the bridegroom is taken away from them, and then they will fast on that day’ (2:20). Some conclude that the logion is a post hoc attempt to justify ‘Christian’ fasting practices (e.g. Didache 8:1), while others maintain that it alludes to the nature of the post-crucifixion period. This article (re)introduces into this discussion one of the earliest interpretations of Mark 2:20: Origen’s interpretation of the ‘day’ of the bridegroom’s absence as the eschatological Day of Atonement (Hom. Lev. 9). Second, it explores the extent to which a Yom Kippur typology illuminates Mark’s portrayal of the interstice between the death and resurrection of Jesus, on the one hand, and the parousia of the Son of Man, on the other. My suggestion is that the Markan logion enfolds the disciples into an apocalyptic season of Yom Kippur ‘affliction’ and anticipation.
Clonal expression and structural analysis of polylactic acid degrading enzyme S8SP from Bacillus safensis
Authors: Wang Yujun , Zhang Yuanyi , Li Chunwang , Meng Siqi , Wang Dandan , Zhao Lehui , Wang Zhanyong 
Published: February 2025

Abstract
Polylactic acid (PLA) is one of the most popular biodegradable plastics favored over traditional plastics. However, it is more difficult to degrade than other biodegradable plastics probably due to the low species and number of PLA-degrading microorganisms degrading enzymes in the environment. Therefore, identifying PLA-degrading microorganisms and enzymes is of great significance for the popularization and application of PLA. This study identified a PLA-degrading enzyme, S8 serine peptidase (S8SP), from Bacillus safensis, and the heterologous expression of S8SP was conducted in Escherichia coli. PLA degradation ability of S8SP was investigated using scanning electron microscopy and water contact angle. The surface of S8SP-degraded PLA films showed obvious cracks and pits and exhibited improved hydrophilicity. The molecular weight of S8SP was about 42 kDa, and its optimum temperature and pH were 40 °C and 8.0, respectively. S8SP could maintain high stability in the temperature range of 30-40 °C and pH range of 7.0-9.0. Sodium ions (Na+), potassium ions (K+), Triton X-100, and Tween-80 promoted the enzyme activity of S8SP. S8SP had a high similarity degree to S8 serine peptidase from the genus Bacillus, and had the classical hydrolase-catalyzed triplet structure.
Reduction of the type Ia supernova host galaxy step in the outer regions of galaxies
Authors: Toy M , Wiseman P , Sullivan M , Scolnic D , Vincenzi M , Brout D , Davis T M , Frohmaier C , Galbany L , Lidman C , Lee J , Kelsey L , Kessler R , Möller A , Popovic B , Sánchez B O , Shah P , Smith M , Allam S , Aguena M , Alves O , Bacon D , Brooks D , Burke D L , Rosell A Carnero , Carretero J , da Costa L N , Pereira M E S , Desai S , Diehl H T , Doel P , Drlica-Wagner A , Everett S , Ferrero I , Flaugher B , Frieman J , García-Bellido J , Gatti M , Gaztanaga E , Giannini G , Gruendl R A , Gutierrez G , Hinton S R , Hollowood D L , Honscheid K , James D J , Lahav O , Lee S , Marshall J L , Mena-Fernández J , Miquel R , Palmese A , Pieres A , Malagón A A Plazas , Romer A K , Samuroff S , Sanchez E , Cid D Sanchez , Schubnell M , Suchyta E , Swanson M E C , Tarle G , Tucker D L , Vikram V , Walker A R , Weaverdyck N 
Published: February 2025

Abstract
Using 1533 type Ia supernovae (SNe Ia) from the five-year sample of the Dark Energy Survey (DES), we investigate the relationship between the projected galactocentric separation of the SNe and their host galaxies and their light curves and standardization. We show, for the first time, that the difference in SN Ia post-standardization brightnesses between high and low-mass hosts reduces from 0.078 ± 0.011 mag in the full sample to 0.036 ± 0.018 mag for SNe Ia located in the outer regions of their host galaxies, while increasing to 0.100 ± 0.014 mag for SNe in the inner regions. The difference in the size of the mass step between inner and outer regions is 0.064 ± 0.023 mag. In these inner regions, the step can be reduced (but not removed) using a model where the RV of dust along the line-of-sight to the SN changes as a function of galaxy properties. We investigate the remaining difference using the distributions of the SN Ia stretch parameter to test the inferred age of SN progenitors. Comparing red (older) environments only, outer regions have a higher proportion of high-stretch SNe and a more homogeneous stretch distribution. However, this effect cannot explain the reduction in significance of any Hubble residual step in outer regions. We conclude that the standardized distances of SNe Ia located in the outer regions of galaxies are less affected by their global host galaxy properties than those in the inner regions.
Multi-Wavelength Analysis of AT 2023sva: a Luminous Orphan Afterglow With Evidence for a Structured Jet
Authors: Srinivasaragavan Gokul P , Perley Daniel A , Ho Anna Y Q , O’Connor Brendan , Postigo Antonio de Ugarte , Sarin Nikhil , Cenko S Bradley , Sollerman Jesper , Rhodes Lauren , Green David A , Svinkin Dmitry S , Bhalerao Varun , Waratkar Gaurav , Nayana A J , Chandra Poonam , Miller M Coleman , Malesani Daniele B , Ryan Geoffrey , Srijan Suryansh , Bellm Eric C , Burns Eric , Titterington David J , Stone Maria B , Purdum Josiah , Ahumada Tomás , Anupama G C , Barway Sudhanshu , Coughlin Michael W , Drake Andrew , Fender Rob , Fernández José F Agüí , Frederiks Dmitry D , Geier Stefan , Graham Matthew J , Kasliwal Mansi M , Kulkarni S R , Kumar Harsh , Li Maggie L , Laher Russ R , Lysenko Alexandra L , Parwani Gopal , Perley Richard A , Ridnaia Anna V , Salgundi Anirudh , Smith Roger , Sravan Niharika , Swain Vishwajeet , Thöne Christina C , Tsvetkova Anastasia E , Ulanov Mikhail V , Vail Jada , Wise Jacob L , Wold Avery 
Published: February 2025

Abstract
We present multi-wavelength analysis of ZTF23abelseb (AT 2023sva), an optically discovered fast-fading (Δmr = 2.2 mag in Δt = 0.74 days), luminous (Mr ∼ −30.0 mag) and red (g − r = 0.50 mag) transient at z = 2.28 with accompanying luminous radio emission. AT 2023sva does not possess a γ-ray burst (GRB) counterpart to an isotropic equivalent energy limit of Eγ, iso &lt; 1.6 × 1052 erg, determined through searching γ-ray satellite archives between the last non-detection and first detection, making it the sixth example of an optically-discovered afterglow with a redshift measurement and no detected GRB counterpart. We analyze AT 2023sva’s optical, radio, and X-ray observations to characterize the source. From radio analyses, we find the clear presence of strong interstellar scintillation (ISS) 72 days after the initial explosion, allowing us to place constraints on the source’s angular size and bulk Lorentz factor. When comparing the source sizes derived from ISS of orphan events to those of the classical GRB population, we find orphan events have statistically smaller source sizes. We also utilize Bayesian techniques to model the multi-wavelength afterglow. Within this framework, we find evidence that AT 2023sva possesses a shallow power-law structured jet viewed slightly off-axis (θv = 0.07 ± 0.02) just outside of the jet’s core opening angle (θc = 0.06 ± 0.02). We determine this is likely the reason for the lack of a detected GRB counterpart, but also investigate other scenarios. AT 2023sva’s evidence for possessing a structured jet stresses the importance of broadening orphan afterglow search strategies to a diverse range of GRB jet angular energy profiles, to maximize the return of future optical surveys.