bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic factors in sinonasal cancers: A multicenter pooled analysis.
Authors: Hernando-Calvo Alberto , Stefanovic Milica , Huang Shao Hui , Brenes Castro Jesús , Su Jie , O'Sullivan Brian , Ringash Jolie , Lozano Alicia , Cirauqui Beatriz , Hahn Ezra , Teruel Iris , de Almeida John R , Marruecos Jordi , Witterick Ian , Rubió-Casadevall Jordi , Goldstein David Paul , Siu Lillian L. , Waldron John , Spreafico Anna , Oliva Marc 
Published: June 2022

6092 Background: Sinonasal cancers (SC) are heterogeneous diseases. Despite multimodality treatment, overall survival (OS) remains unsatisfactory. We aimed to identify prognostic factors (PFs) associated with patterns of failure and OS in non-metastatic SC (nmSC). Methods: We retrospectively reviewed a pooled dataset of nmSC from Princess Margaret (Canada) and Catalan Institute of Oncology (Spain) treated with definitive surgery ± postop radiotherapy (RT) or RT ± chemo according to institutional protocols between 2010-2019. In squamous cell carcinoma (SCC), HPV status was tested by p16 staining, and HPV DNA (ISH or PCR) if equivocal. The primary goal was to assess the association of tumor histology, stage (by 7th edition TNM), and other clinicopathological variables on locoregional control (LRC), distant control (DC) and OS. Actuarial rates were calculated with Kaplan–Meier (KM) method. Multivariable analysis (MVA) calculated hazard ratios (aHR) adjusted for histology type, T-/N-categories, and primary treatment. Results: Out of 342 pts, median age was 62 years (y) (range 21-96), Male:Female = 212:130, 95% had ECOG 0-1. Tumor histology types were: 192 (56%) SCC (p16+: 35; p16-/untested: 157), 40 (12%) adenocarcinoma (AD), 33 (10%) sinonasal undifferentiated carcinoma or sinonasal neuroendocrine tumors (SNUC/SNEC), 28 (8%) malignant melanoma (MM), 27 (8%) esthesioneuroblastoma (ES) and 22 (6%) adenoid cystic carcinoma (ACC). Median follow up was 3.6 y (range 0.1-11.3). Three-year actuarial rates for each endpoint are included in table. The PFs for LRC by MVA were: SNUC/SNEC (vs SCC) histology, T3-4 (vs T1-2: aHR 2.4, p = < 0.01) and N+ (vs N-: aHR 1.7, p = 0.02) diseases. The PFs for DC were: MM (vs SCC) and SNUC/SNEC (vs SCC) histology, and T3-4 (vs T1-2: aHR 6.0, p = 0.01) disease. The PFs for OS were: MM (vs SCC) histology, older age (aHR 1.0, p < 0.01), T3-4 (vs T1-2: aHR 5.6, p < 0.01), and N+ (vs N-: aHR 2.5, p < 0.01) disease. There was no difference in primary surgery vs RT in any outcome endpoint (all p > 0.05). p16+ SCC had a marginally higher LRC but similar DC and OS vs p16-/untested SCC (table). Conclusions: This large multicentre cohort of nmSC shows different patterns of relapse and survival with different tumor histologies. Our results suggest that individualization of treatment and follow-up strategies by histologic type is recommended to optimize outcomes in these orphan diseases. [Table: see text]
Self-care for head and neck cancer survivors with lymphedema and fibrosis: A pilot randomized clinical trial.
Authors: Deng Jie , Lin Alexander , Aryal Subhash , Lukens John Nicholas , McMenamin Erin , Quinn Ryan , Cohn Joy , Spinelli Bryan , Murphy Barbara A. 
Published: June 2022

6094 Background: Lymphedema and fibrosis (LEF) are debilitating late effects in head and neck cancer survivors (HNCS). Initial therapy is usually directed by therapists following which patients undertake a LEF self-care program (SCP). No evidence based LEF-SCP are available. We report on the feasibility and preliminary efficacy data of a multifaceted LEF-SCP. Methods: 59 HNCS with LEF were randomized to: Usual care (n = 20), usual care + LEF-SCP (n = 20), and usual care + LEF-SCP + routine follow-up with a lymphedema therapist (n = 19). Assessments were conducted at baseline, 3-, 6-, 9-, and 12-months. Outcome measures include feasibility and preliminary efficacy (LEF progression, symptom burden, and jaw range of motion [ROM]). Multivariate covariance pattern model analysis was used to test for difference between arms. Results: 1) Feasibility: LEF-SCP training sessions - 80% completion rate; 90% satisfaction with the LEF-SCP; self-care adherence was similar between arms; no adverse event. 2) Preliminary Efficacy: Compared to usual care, participants randomized to LEF-SCP (+/- follow-up) showed a decrease in LEF severity (p < 0.05), reduction in symptom burden (p < 0.05), without significant improvement in jaw ROM. No significant differences were noted between the patients +/- follow-up with a lymphedema therapist. There was a trend to improved self-efficacy in patients participating in the LEF-SCP. Conclusions: The LEF-SCP is feasible and potentially efficacious for HNCS. Further testing is warranted. Clinical trial information: NCT03030859.
Continuum theories of structured dielectrics
Authors: Blossey Ralf , Podgornik Rudolf 
Published: June 2022

Abstract
Aqueous dielectrics are ubiquitous in soft- and bio-nano matter systems. The theoretical description of such systems in terms of continuum (“macroscopic”) theory remains a serious challenge. In this perspective we first review the existing continuum phenomenological approaches that have been developed in the past decades. In order to describe a path to advance continuum theory beyond these approaches we then take recourse to the Onsager-Dupuis theory of the dielectric behaviour of ice, which, for the case of a solid dielectric, exemplified important conceptual issues we deem relevant for the development of a more fundamental continuum theory of liquid dielectrics. Subsequently, we discuss our recently proposed continuum field theory of structured dielectrics, which provides a generalized approach to the dielectric behavior of such systems.
Serum 25-Hydroxyvitamin D is Associated With Bone Microarchitecture and Strength in a Multiracial Cohort of Young Adults
Authors: Garrahan Margaret , Gehman Sarah , Rudolph Sara E , Tenforde Adam S , Ackerman Kathryn E , Popp Kristin L , Bouxsein Mary L , Sahni Shivani 
Published: June 2022

Abstract

Purpose
To determine whether 25-hydroxyvitamin D (25-OH D) levels are associated with bone outcomes in a multiracial cohort of young adults.

Methods
This cross-sectional study included 165 participants (83 men, 82 women, 18-30 years of age) who self-identified as Asian, Black, or White. We measured bone microarchitecture and strength of the distal radius and tibia using high-resolution peripheral quantitative computed tomography. We used linear regression to estimate the association between 25-OH D (ng/mL) and bone measurements, adjusting for race, sex, age, weight, height, calcium intake, physical activity, and season.

Results
A total of 43.6% of participants were 25-OH D deficient (&lt;20 ng/mL) with greater prevalence in Asian (38.9%) and Black (43.1%) compared with White (18.0%) participants (P &lt; 0.001). At the distal radius, 25-OH D was positively associated with cortical area, trabecular density, cortical thickness, cortical porosity, and failure load (P &lt; 0.05 for all). At the distal tibia, higher 25-OH D was associated with higher cortical area, trabecular density, trabecular number, failure load, and lower trabecular separation and cortical density (P &lt; 0.05 for all). After multivariable adjustment, those with 25-OH D deficiency had generally worse bone microarchitecture than those with 25-OH D sufficiency. Black individuals had largely more favorable bone outcomes than Asian and White individuals, despite higher prevalence of 25-OH D deficiency.

Conclusions
We found a high prevalence of 25-OH D deficiency in a multiracial cohort of young adults. Lower 25-OH D was associated with worse bone outcomes at the distal radius and tibia at the time of peak bone mass, warranting further attention to vitamin D status in young adults.
Alternative Modes Of Thought
Authors: Burke Peter 
Published: June 2022

AbstractThis essay—a contribution to the Common Knowledge symposium on contextualism—is concerned with the gradual rise (in Europe and then more generally in the West) of awareness of the existence of modes of thought or systems of belief that are different from those that are dominant in one's own culture. The awareness can be found in the seventeenth and eighteenth centuries (for example, in John Locke, Bernard de Fontenelle, and Giambattista Vico) but was developed further in the early to mid-twentieth century. Its main consequence has been to encourage individuals to distance themselves from their own system—to criticize and change it.
Genome sequence and pathogenicity ofVibrio vulnificusstrain MCCC 1A08743 isolated from contaminated prawns
Authors: Li Jie , Zhu Yiqing , Ma Zhenxia , Yang Fu 
Published: June 2022

ABSTRACTVibrio vulnificus is an opportunistic pathogen that naturally inhabits sea water globally and is responsible for most vibriosis-related deaths. The consumption of V. vulnificus contaminated seafood and exposure of wounds to Vibrio can result in systemic infection, with increased risks of amputation and extremely high rates of mortality. However, the pathogenicity and virulence factors of V. vulnificus are not fully understood. The genomic characterization of V. vulnificus will be helpful to extend our understanding on V. vulnificus at a genomic level. In this manuscript, the genome of V. vulnificus strain MCCC 1A08743 isolated from contaminated prawns from Zhanjiang, China, was sequenced using Illumina HiSeq X Ten system and annotated through multiple databases. The strain MCCC 1A08743 genome included 4371 protein-coding genes and 117 RNA genes. Average nucleotide identity analysis and core genome phylogenetic analysis revealed that MCCC 1A08743 was most closely related to strains from clinical samples from the United States. Pathogenicity annotation of the MCCC 1A08743 genome, using Virulence Factor Database and Pathogen-Host Interactions database, predicted the pathogenicity of the strain, and this was confirmed using mice infection experiments, which indicated that V. vulnificus strain MCCC 1A08743 could infect C57BL/6J mice and cause liver lesions.This article has an associated First Person interview with the first author of the paper.
Coping with captivity: takeoff speed and load-lifting capacity are unaffected by substantial changes in body condition for a passerine bird
Authors: Kou Guanqun , Wang Yang , Dudley Robert , Wu Yuefeng , Li Dongming 
Published: June 2022

ABSTRACT
Captivity presumably challenges the physiological equilibrium of birds and thus influences flight ability. However, the extent to which captive birds exhibit altered features underpinning maximum flight performance remains largely unknown. Here, we studied changes in physiological condition and load-lifting performance in the Eurasian tree sparrow (Passer montanus) over 15, 30 and 45 days of captivity. Sparrows showed body mass constancy over time but also an increased hematocrit at 15 days of captivity; both relative pectoralis mass and pectoralis fat content increased at 30 days. However, maximum takeoff speed and maximum lifted load remained largely unchanged until 45 days of captivity. Wingbeat frequency was independent of captivity duration and loading condition, whereas body angle and stroke plane angle varied only with maximum loading and not with duration of captivity. Overall, these results suggest that captive birds can maintain maximum flight performance when experiencing dramatic changes in both internal milieu and external environment.
Susceptibility-weighted imaging in intracranial hemorrhage: not all bleeds are black
Authors: Weerink Linda BM , Appelman Auke PA , Kloet Reina W , Van der Hoorn Anouk 
Published: June 2022

To correctly recognize intracranial hemorrhage (ICH) and differentiate it from other lesions, knowledge of the imaging characteristics of an ICH on susceptibility weighted imaging (SWI) is essential. It is a common misconception that blood is always black on SWI, and it is important to realize that hemorrhage has a variable appearance in different stages on SWI. Furthermore, the presence of a low signal on SWI does not equal the presence of blood products. In this review, the appearance of ICH on SWI during all its stages and common other causes of a low signal on SWI are further discussed and illustrated.
Influence of features of communicative qualities of heads and employees of law-enforcement bodies on professional activity
Authors: Maltseva Tatyana , Teregulova Oxana , Ul'yanova Anzhelika 
Published: June 2022

Despite the wide range of studies devoted to the chosen topic, at present, police officers are faced with the problems of building dialogues both among themselves and with the special contingent. To solve them, it is necessary to study in detail the features of the communicative qualities of employees and their impact on professional activities.
The subject of the study is the features of the communicative qualities of the leaders and employees of the internal affairs department. The purpose of the study is to identify the features of the communicative qualities of police officers and their impact on professional activities.
The collection of empirical material was carried out using: 1) a test for assessing self-control in communication (M. Snyder); 2) a test for assessing communication skills (A.A. Karelina). The study involved 145 respondents.
The participation of the heads and employees of the internal affairs department in communicative situations of a professional nature helps them to enrich the subjective experience of self-organization, self-control, self-reflection, self-presentation, self-regulation and self-expression in official activities. This strategy contributes to the development of social intelligence of police officers, activity and creativity, self-knowledge.
When performing their professional tasks and functions, building communication links and relationships with their colleagues and citizens, police officers form their own image as a professional, as well as public opinion about the entire system of internal affairs bodies as a whole.
Z praktyki epistolarnej autorki „Teorii listu”. Casus Stefania Skwarczyńska–Jerzy Zawieyski
Authors: Tyszkiewicz Barbara 
Published: June 2022

Opublikowana w 1937 roku Teoria listu Stefanii Skwarczyńskiej (1902–1988) wciąż pozostaje istotną płaszczyzną odniesienia dla współczesnych literaturoznawców i edytorów. Do przybliżenia mniej znanej, epistolarnej praktyki autorki tej monografii posłużył zespół 25 prywatnych listów z lat 1948–1968, których adresatem był Jerzy Zawieyski (1902–1969). Te pisemne kontakty badaczki z dramaturgiem, prozaikiem i katolickim działaczem społeczno-politycznym zostały omówione w kilku aspektach. Poczynając od okoliczności nawiązania korespondencyjnego dialogu, przedstawiono zdynamizowane, biograficzne relacje łączące nadawczynię z odbiorcą listów, a rzutujące na poruszaną przez nich problematykę: tematy literackie (skoncentrowane wokół twórczości pisarza), religijną wrażliwość i społeczno-polityczne uwikłania katolików w komunistycznym państwie, pracę naukową oraz sprawy prywatne Skwarczyńskiej. Opisowi została poddana materialna i wizualna postać ineditów oraz specyfika ich kompozycji formalnej. Chronologiczne luki w materiałach źródłowych pokazano na tle różnic światopoglądowych, które dzieliły katolickich intelektualistów pozostających (jak Skwarczyńska) w zasięgu oddziaływania Stowarzyszenia PAX i związanych (jak Zawieyski) ze środowiskiem „Tygodnika Powszechnego” i Kołem Posłów Znak. W zakończeniu wskazano zagadnienia współczesnej recepcji Teorii listu oraz związane z nimi – badawcze i edytorskie dylematy.
Associations between pre-stroke physical activity and physical quality of life three months after stroke in patients with mild disability
Authors: Zirnsak Melanie , Meisinger Christine , Linseisen Jakob , Ertl Michael , Zickler Philipp , Naumann Markus , Kirchberger Inge 
Published: June 2022

Background
Much is known about the association between physical activity and the occurrence of stroke. However, the evidence about the correlation between pre-stroke physical activity and post-stroke quality of life remains inconsistent. Thus, there is a high public health relevance to the topic.

Aim
The aim of this study was to investigate the association between pre-stroke physical activity and physical quality of life after three months.

Methods
Data arises from 858 patients with stroke included a prospective single-centre observational cohort study in Augsburg, Germany, between September 2018 and November 2019. The participants were recruited at the Department of Neurology and Clinical Neurophysiology, University Hospital of Augsburg after their stroke event. The level of physical activity was determined following the short form of the International Physical Activity Questionnaire at baseline. Physical quality of life was assessed three months after hospital discharge using the German version of the Stroke Impact Scale (SIS). A multiple linear regression model and a quantile regression were carried out.

Results
A total of 497 patients were included in the analysis (mean age 69.6, 58.8% male), 26.2% had a high, 18.9% a moderate and 54.9% a low level of pre-stroke physical activity. Patients with high pre-stroke physical activity had a significantly better physical quality of life three months after stroke in the SIS physical domain (beta = 4.1) and in the SIS subdomains hand function (beta = 5.6), mobility (beta = 4.1) and activities of daily living (beta = 3.7). In the physical domain and the subdomain mobility, the effect was especially strong for persons with low physical quality of life after three months.

Conclusion
Pre-stroke physical activity seems to have an important and positive association with physical quality of life after three months in patients with mild disability. Further studies are needed to confirm these results.
What will the cardiovascular disease slowdown cost? Modelling the impact of CVD trends on dementia, disability, and economic costs in England and Wales from 2020–2029
Authors: Collins Brendan , Bandosz Piotr , Guzman-Castillo Maria , Pearson-Stuttard Jonathan , Stoye George , McCauley Jeremy , Ahmadi-Abhari Sara , Araghi Marzieh , Shipley Martin J. , Capewell Simon , French Eric , Brunner Eric J. , O’Flaherty Martin 
Published: June 2022

Background
There is uncertainty around the health impact and economic costs of the recent slowing of the historical decline in cardiovascular disease (CVD) incidence and the future impact on dementia and disability.

Methods
Previously validated IMPACT Better Ageing Markov model for England and Wales, integrating English Longitudinal Study of Ageing (ELSA) data for 17,906 ELSA participants followed from 1998 to 2012, linked to NHS Hospital Episode Statistics. Counterfactual design comparing two scenarios: Scenario 1. CVD Plateau—age-specific CVD incidence remains at 2011 levels, thus continuing recent trends. Scenario 2. CVD Fall—age-specific CVD incidence goes on declining, following longer-term trends. The main outcome measures were age-related healthcare costs, social care costs, opportunity costs of informal care, and quality adjusted life years (valued at £60,000 per QALY).

Findings
The total 10 year cumulative incremental net monetary cost associated with a persistent plateauing of CVD would be approximately £54 billion (95% uncertainty interval £14.3-£96.2 billion), made up of some £13 billion (£8.8-£16.7 billion) healthcare costs, £1.5 billion (-£0.9-£4.0 billion) social care costs, £8 billion (£3.4-£12.8 billion) informal care and £32 billion (£0.3-£67.6 billion) value of lost QALYs.

Interpretation
After previous, dramatic falls, CVD incidence has recently plateaued. That slowdown could substantially increase health and social care costs over the next ten years. Healthcare costs are likely to increase more than social care costs in absolute terms, but social care costs will increase more in relative terms. Given the links between COVID-19 and cardiovascular health, effective cardiovascular prevention policies need to be revitalised urgently.
Pharmacological analysis of Empagliflozin: Acting through the CaMKII pathway in type 2 diabetes and acute cardiovascular events
Authors: Shao Guangyao 
Published: June 2022

BackgroundType 2 diabetes mellitus is a high-risk factor for acute cardiovascular events. Some reports show that Empagliflozin has a protective effect on cardiovascular events and diabetes mellitus, and Empagliflozin can act on the CaMKII pathway. However, the specific gene of action is not precise. Therefore, this study investigated the target genes of Empagliflozin by integrated gene analysis and molecular docking method to provide a theoretical basis for further elucidating the mechanism of action of Empagliflozin.MethodIn this study, we obtained 12 datasets from GEO, divided into experimental and validation groups, with a total of 376 samples. We then integrated CaMKII pathway-related genes from OMIM, NCBI, and genecards databases. We then intersected them with the differential genes we obtained to obtain 5 common genes and performed functional enrichment analysis. We then performed group comparisons in the validation set, and we obtained 2 clinically significant genes. Then we performed group comparison in the validation set, and we obtained 2 clinically significant genes, followed by molecular docking analysis with pymol, autodock software. We obtained molecular docking models for the 2 genes.ConclusionIn this study, we obtainedCaMK2GandPPP1CA, genes associated with the CaMKII pathway and type 2 diabetes and acute cardiovascular events, by integrative gene analysis and validated their expression in the relevant dataset. We also derived that Empagliflozin acts on amino acidTRP-125ofCaMK2Ggene andGLN-249 ASP-210 ASP-208ofPPP1CAthrough CaMKII pathway, thus acting on type 2 diabetes and acute cardiovascular events by molecular docking technique.
Covid-19 vaccination intensions among literate Ghanaians: Still the need to dissipate fear and build trust on vaccine efficacy?
Authors: Awuni Joseph Agebase , Ayamga Michael , Dagunga Gilbert 
Published: June 2022

Purpose
The study examined Covid-19 vaccinations intentions among literate Ghanaians and how it is been influenced by vaccine mistrust and the fear of the unforeseen side effects.

Design/Methodology/Approach
We used cross sectional data collected from 223 respondents by means of questionnaire disseminated through social media from 16th to 20th April, 2021. Likert-scale questions were asked regarding the knowledge, attitudes and perceptions of literate Ghanaians towards COVID-19 vaccines. Kruskal-Wallis and sample t-test were performed to ascertain the differences in vaccination intentions between key socioeconomic variables. A pairwise correlation was performed to examine the relationship between vaccination intensions and fear of the unforeseen, mistrust of the vaccine and concerns of profiteering. Finally, a binary probit regression model was fitted to examine the predictive effect of key variables on respondent’s vaccination intentions.

Findings
The results revealed a relatively low level of knowledge about the safety and efficacy of the COVID-19 vaccines. The sample t-test showed that males have a relatively positive attitude towards the COVID-19 vaccines than females at 5% level of significance. Mistrust of vaccine safety and efficacy have a significant negative influence on vaccination intensions at 1% significance level.

Originality/Value
This study provides the Ghanaian government and other stakeholders with useful information to aid in educational campaigns on the safety and effectiveness of the COVID-19 vaccine. More campaign efforts towards females could help increase uptake given their relatively poor attitudes towards the vaccine.