bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemahaman Tentang Esensi Orang Percaya Menurut Surat Kolose Dalam Upaya Peneguhan Iman Jemaat
Authors: Paende Elvin 
Published: October 2022

Pemahaman esensi diri sebagai orang percaya merupakan dasar yang penting bagi struktur kepercayaan atau keyakinannya. Bahkan memahami esesnsi diri sebagai orang percaya penting untuk pola tingkah laku setiap hari. Bagaimanapun juga pemahaman yang benar tentang diri sendirilah yang menentukan apa yang dilakukan seseorang bukan sebaliknya (Band. Roma 7: 24-25; Lukas 5: 8). Seseorang menerima Tuhan Yesus sebagai Tuhan dan juruselamatnya ia memiliki hidup yang kekal. Ketika itu ia diperdamaikan dengan Allah sehingga menjadi kudus, tak bercacat, dan tak bercela. Ia dipenuhi dalam Kristus lalu meninggalkan tubuh yang berdosa dan dihidupkan bersama Yesus Kristus. Di dalam Kristus diciptakan menjadi manusia baru. Tetapi pada kenyataannya ada banyak orang Kristen yang tidak memahami tentang esensi orang percaya. Karena itu banyak orang percaya tidak bertumbuh secara rohani dan tidak menemukan arti keberadaannya sebagai orang Kristen serta menjalani kehidupan Kristen tidak sebagaimana mestinya. Hal ini dikarenakan mereka belum mengerti dan memahami esensi dan identitas dirinya di dalam Yesus Kristus. Karena itu pemahaman tentang esensi orang percaya menurut surat Kolose dalam upaya meneguhan iman orang percaya sangat penting. Penulisan ini menggunakan metode bibliologis dan metode deskriptif, yang ditindaklanjuti dengan penelitian literatur. Dikatakan bibliologis, karena penelitian ini berupaya membentuk pemahaman, pengertian, wawasan theologis berdasarkan atau bersumber dari teks alkitab. Penelitian yang dilakukan memakai studi kata dan pendekatan kitab. Dikatakan Metode deskriptif karena berusaha untuk menjelaskan permasalahan yang tetap relevan dan memusatkan diri pada pemecahan masalah yang ada pada masa kini.
PENTINGNYA PENDIDIKAN TEOLOGI BERDASARKAN EZRA 7:10 DAN IMPLIKASINYA BAGI PELAYANAN HAMBA TUHAN
Authors: Fallo Ariance 
Published: October 2022

Artikel ini merupakan uraian mengenai pentingnya Pendidikan Teologi bagi seorang yang terpanggil menjadi hamba Tuhan. Ditulis dalam bentuk eksegesis dari kitab Ezra 7:10. Pendidikan teologi sangat penting bagi hamba Tuhan, yakni bagaimana seorang hamba Tuhan memiliki komitmen untuk meneliti, melakukan dan mengajarkan kebenaran Firman Tuhan. Penelitian dan pengajaran Firman Tuhan dapat diterima melalui studi teologi secara formal, maupun non formal.
Eksegesis kitab Ezra 7:10 menjadi sebuah cara untuk menemukan dasar atau pijakan pengembangan pentingnya pemahaman teologi dimiliki oleh seorang hamba Tuhan yang notabene berperan sebagai pengajar, atau pendeta dan misionaris. Karena itu, artikel ini direkomendasikan untuk semua hamba Tuhan dalam peran apa pun untuk dapat memiliki dasar teologi yang sehat berdasarkan kebenaran Firman Tuhan.
Estimating the changing burden of disease attributable to childhood stunting, wasting and underweight in South Africa for 2000, 2006 and 2012
Authors: Nannan N , Laubscher R , Nel J H , Neethling I , Dhansay M A , Turawa E B , Labadarios D , Pacella R , Bradshaw D , Pillay van-Wyk V 
Published: October 2022

Background. National estimates of childhood undernutrition display uncertainty; however, it is known that stunting is the most prevalent deficiency. Child undernutrition is manifest in poor communities but is a modifiable risk factor. The intention of the study was to quantify trends in the indicators of child undernutrition to aid policymakers.
Objectives. To estimate the burden of diseases attributable to stunting, wasting and underweight and their aggregate effects in South African (SA) children under the age of 5 years during 2000, 2006 and 2012.
Methods. The study applied comparative risk assessment methodology. Data sources for estimates of prevalence and population distribution of exposure in children under 5 years were the National Food Consumption surveys and the SA National Health and Nutrition Examination Survey conducted close to the target year of burden. Childhood undernutrition was estimated for stunting, wasting and underweight and their combined ‘aggregate effect’ using the World Health Organization (WHO) 2006 standard. Population-attributable fractions for the disease outcomes of diarrhoea, lower respiratory tract infections, measles and protein-energy malnutrition were applied to SA burden of disease estimates of deaths, years of life lost, years lived with a disability and disability-adjusted life years for 2000, 2006 and 2012.
Results. Among children aged under 5 years between 1999 and 2012, the distribution of anthropometric measurements <‒2 standard deviations from the WHO median showed little change for stunting (28.4% v. 26.6%), wasting (2.6% v. 2.8%) and underweight (7.6% v. 6.1%). In the same age group in 2012, attributable deaths due to wasting and aggregated burden accounted for 21.4% and 33.2% of the total deaths, respectively. Attributable death rates due to wasting and aggregate effects decreased from ~310 per 100 000 in 2006 to 185 per 100 000 in 2012.
Conclusion. The study shows that reduction of childhood undernutrition would have a substantial impact on child mortality. We need to understand why we are not penetrating the factors related to nutrition of children that will lead to reducing levels of stunting.
Opioid Dose Trajectories and Associations With Mortality, Opioid Use Disorder, Continued Opioid Therapy, and Health Plan Disenrollment
Authors: Binswanger Ingrid A. , Shetterly Susan M. , Xu Stanley , Narwaney Komal J. , McClure David L. , Rinehart Deborah J. , Nguyen Anh P. , Glanz Jason M. 
Published: October 2022

ImportanceUncertainty remains about the longer-term benefits and harms of different opioid management strategies, such as tapering and dose escalation. For instance, opioid tapering could help patients reduce opioid exposure to prevent opioid use disorder, but patients may also seek care elsewhere and engage in nonprescribed opioid use.ObjectiveTo evaluate the association between opioid dose trajectories observed in practice and patient outcomes.Design, Setting, and ParticipantsThis retrospective cohort study was conducted in 3 health systems in Colorado and Wisconsin. The study population included patients receiving long-term opioid therapy between 50 and 200 morphine milligram equivalents between August 1, 2014, and July 31, 2017. Follow-up ended on December 31, 2019. Data were analyzed from January 2020 to August 2022.ExposuresGroup-based trajectory modeling identified 5 dosing trajectories over 1 year: 1 decreasing, 1 high-dose increasing, and 3 stable.Main Outcomes and MeasuresPrimary outcomes assessed after the trajectory period were 1-year all-cause mortality, incident opioid use disorder, continued opioid therapy at 1 year, and health plan disenrollment. Associations were tested using Cox proportional hazards regression and log-binomial models, adjusting for baseline covariates.ResultsA total of 3913 patients (mean [SD] age, 59.2 [14.4] years; 2767 White non-Hispanic [70.7%]; 2237 female patients [57.2%]) were included in the study. Compared with stable trajectories, the decreasing dose trajectory was negatively associated with opioid use disorder (adjusted hazard ratio [aHR], 0.40; 95% CI, 0.29-0.55) and continued opioid therapy (site 1: adjusted relative risk [aRR], 0.39; 95% CI, 0.34-0.44), but was positively associated with health plan disenrollment (aHR, 1.66; 95% CI, 1.24-2.22). The decreasing trajectory was not associated with mortality (aHR, 1.28; 95% CI, 0.87-1.86). In contrast, the high-dose increasing trajectory was positively associated with mortality (aHR, 2.19; 95% CI, 1.44-3.32) and opioid use disorder (aHR, 1.81; 95% CI, 1.39-2.37) but was not associated with disenrollment (aHR, 0.90; 95% CI, 0.56-1.42) or continued opioid therapy (site 1: aRR, 0.98; 95% CI, 0.94-1.03).Conclusions and RelevanceIn this cohort study, decreasing opioid dose was associated with reduced risk of opioid use disorder and continued opioid therapy but increased risk of disenrollment compared with stable dosing, whereas the high-dose increasing trajectory was associated with an increased risk of mortality and opioid use disorder. These findings can inform opioid management decision-making.
Resource booms, state economic conditions, and child food security
Authors: Cho Seung Jin , Kreider Brent , Winters John V. 
Published: October 2022

AbstractChild food security is a longstanding concern to policymakers, exacerbated by economic slack and instability. We use the fracking era oil and gas boom of the early 2000s as a natural experiment to examine the importance of state economic conditions for child food security. The fracking boom was a large and unexpected economic shock that substantially improved labor market conditions in states with oil and gas resources but not elsewhere. We find that increases in oil and gas labor income improve child food security, especially for children with less educated parents and those residing in single‐mother households.
Vedolizumab‐related agranulocytosis with Epstein‐Barr virus esophagitis: A case report
Authors: Le Puo‐Hsien , Wu Ren‐Chin , Chen Chien‐Ming , Kuo Chia‐Jung , Su Ming‐Yao , Chiu Cheng‐Tang 
Published: October 2022

AbstractVedolizumab has a good safety profile for the treatment of inflammatory bowel disease. Agranulocytosis is a rare but fatal condition. Although many drugs are considered to have a high risk of agranulocytosis, no previous study has mentioned vedolizumab. A 71‐year‐old female with Sjogren's syndrome received vedolizumab treatment for moderate to severe ulcerative colitis. Her symptoms improved; however, leukopenia was noted after the first dose. Four days after the second dose, she complained of oral and chest pain. Agranulocytosis, oral candidiasis, and Epstein‐Barr virus esophagitis with ulceration were noted. After granulocyte‐colony stimulating factor treatment, the white blood cell count returned to normal and the esophageal ulcers healed. Vedolizumab is a very safe gut‐selective biologic agent, but it also carries the risk of agranulocytosis.
Role of serum‐free light chain assay for defining response and progression in immunoglobulin secretory multiple myeloma
Authors: Tacchetti Paola , Rocchi Serena , Zamagni Elena , Barbato Simona , Rizzello Ilaria , De Cicco Gabriella , Pantani Lucia , Mancuso Katia , Fusco Alessio , Dozza Luca , Ursi Margherita , Favero Emanuele , Terragna Carolina , Testoni Nicoletta , Cavo Michele 
Published: October 2022

AbstractThe International Myeloma Working Group (IMWG) guidelines recommend using electrophoresis and immunofixation to define response and progressive disease (PD) in immunoglobulin (Ig) secretory multiple myeloma (Ig‐MM), whereas the role of serum‐free light chain (sFLC) is controversial. We retrospectively analyzed the value of adding sFLC assays in the definition of response and PD according to IMWG criteria in 339 Ig‐MM patients treated with a first‐line novel agent‐based therapy (median follow‐up 54 months). sFLC PD was defined according to conventional criteria plus increased sFLC levels, or sFLC escape (sFLCe); progression/sFLCe‐free survival (ePFS) was the time from the start of treatment to the date of first PD or sFLCe, or death; overall survival after PD/sFLCe (OS after Pe) was the time from first PD or sFLCe to the date of death. 148 (44%) patients achieved a complete response and 198 (60%) a normal sFLC ratio (sFLCR). sFLCR normalization was an independent prognostic factor for extended PFS (HR = 0.46, p = 0.001) and OS (HR = 0.47, p = 0.006) by multivariable analysis. 175 (52%) patients experienced PD according to the IMWG criteria, whereas 180 (53%) experienced PD or sFLCe. Overall, a sFLCe was observed in 31 (9%) patients. Median PFS and ePFS were both equal to 36 (95% CI = 32–42, and 32–40, respectively) months. sFLC PD adversely affected the OS after Pe compared to PD with increasing monoclonal Ig only (HR = 0.52, p = 0.012). Our results support the inclusion of the sFLC assay for defining response and PD in Ig‐MM.
Nachhaltiges Design von Struktur‐ und Funktionspolymeren für die Kreislaufwirtschaft
Authors: von Vacano Bernhard , Mangold Hannah , Vandermeulen Guido W. M. , Battagliarin Glauco , Hofmann Maximilian , Bean Jessica , Künkel Andreas 
Published: October 2022

AbstractFür eine nachhaltige Kreislaufwirtschaft müssen Polymere auf rezyklierte und biobasierte Rohstoffe umgestellt werden, und sie müssen bezüglich der Emissionen CO2‐neutral werden. Dies gilt nicht nur für Strukturpolymere, z. B. in Verpackungen oder technischen Anwendungen, sondern auch für Funktionspolymere in flüssigen Formulierungen: in Klebstoffen oder Schmiermitteln, als Verdickungs‐ oder Dispersionsmittel. Am Ende ihrer Lebensdauer müssen Polymere entweder gesammelt und technisch rezykliert werden oder biologisch abbaubar sein, wenn sie nicht sammelbar sind. Fortschritte in der Polymerchemie, in Anwendungen und durch zunehmend rechnergestützte Methoden der Materialwissenschaft ermöglichen einen ganzheitlichen Ansatz: Polymere werden bereits für ihre Rezyklierbarkeit oder biologische Abbaubarkeit konzipiert. Dieser Aufsatz zeigt, wie neue wissenschaftliche Erkenntnisse in Verbindung mit entsprechenden rechtlichen, gesellschaftlichen und wirtschaftlichen Randbedingungen den Weg zu einer umfassenden Kreislaufwirtschaft für Polymere weisen können.
Biosynthetic Elucidation and Structural Revision of Brevione E: Characterization of the Key Dioxygenase for Pathway Branching from Setosusin Biosynthesis
Authors: Yan Dexiu , Matsuda Yudai 
Published: October 2022

AbstractBrevione E (1) is a fungal hexacyclic meroditerpenoid with unique oxepane and cycloheptenone moieties. In this study, we identified the biosynthetic gene cluster of 1 and elucidated its biosynthetic pathway via heterologous expression of the biosynthetic genes and in vitro enzymatic reactions. Surprisingly, reexamination of the structure of 1 revealed a substituted tetrahydrofuran ring instead of the previously proposed oxepane system. Moreover, we determined that cycloheptenone synthesis involves skeletal rearrangement catalyzed by the α‐ketoglutarate‐dependent dioxygenase BrvJ. BrvJ is highly homologous to SetK, which engages in the biosynthesis of another fungal metabolite, setosusin, and accepts the same substrate as BrvJ but performs only simple hydroxylation. Finally, we identified the key amino acid residues critical for product selectivity of BrvJ and SetK, providing insight into how the biosynthesis pathways of 1 and setosusin diverge and how fungi diversify natural products.
Removal and Degradation of Microplastics Using the Magnetic and Nanozyme Activities of Bare Iron Oxide Nanoaggregates
Authors: Zandieh Mohamad , Liu Juewen 
Published: October 2022

AbstractRemoval and degradation of microplastics are often carried out separately. In this work, hydrophilic bare Fe3O4 nanoaggregates allowed efficient removal of the most common microplastics including high‐density polyethylene, polypropylene, polyvinyl chloride, polystyrene, and polyethylene terephthalate. Full extraction was achieved using Fe3O4 at 1 % of the mass of microplastics. Hydrogen bonding is the main force for the adsorption of Fe3O4. Unlike the more commonly used hydrophobically modified Fe3O4 nanoparticles, the bare Fe3O4 benefitted from the peroxidase‐like activity of its exposed surface, enabling further catalytic degradation of microplastics with nearly 100 % efficiency and easy recovery of the Fe3O4.
Remote Editing of Stacked Aromatic Assemblies for Heteroannular C−H Functionalization by a Palladium Switch between Aromatic Rings
Authors: Yu Zhiqian , Liu Qianhui , Li Qian , Huang Zhenmei , Yang Yudong , You Jingsong 
Published: October 2022

AbstractAn approach allowing remote editing of stacked aromatic assemblies for heteroannular C−H functionalization would represent a transformative chemical toolbox that may make the diversification of complex molecules in a straightforward manner. However, such a C−H activation is usually less kinetically and thermodynamically favorable than homoannular ortho C−H activation and remains a fundamental challenge. Herein we disclose an engineer's approach, using a transient ligand as an interim bridge between two aryl rings (analogues to mountaintops) to anchor the metal center on the remote heteroannular C−H bond. As a proof‐of‐concept, we present the palladium‐catalyzed heteroannular C−H olefination of stacked aromatic assemblies with olefins and allylation with vinyl acetates using L‐tert‐leucine acid as a transient ligand. Mechanistic investigations suggest an unusual olefin coordination‐promoted interannular palladium migration process determinative for reversal of the site‐selectivity.
Synthesis of Axially Chiral Biaryls via Enantioselective Ullmann Coupling ofortho‐Chlorinated Aryl Aldehydes Enabled by a Chiral 2,2′‐Bipyridine Ligand
Authors: Perveen Saima , Zhang Shuai , Wang Linghua , Song Peidong , Ouyang Yizhao , Jiao Jiao , Duan Xin‐Hua , Li Pengfei 
Published: October 2022

AbstractThe first nickel‐catalyzed highly enantioselective reductive Ullmann coupling ofortho‐chlorinated aryl aldehyde was achieved under mild reaction conditions with a chiral 2,2′‐bipyridine ligand (+)‐DTB‐SBpy, thus providing axially chiral biphenyl or binaphthyl dials with up to 99 % yield and 99.5:0.5 er. The versatility of the products as common synthetic intermediates for diverse axially chiral ligands, catalysts, and functional molecules was demonstrated by short‐step transformations. This protocol also allowed the concise and highly enantioselective formal total synthesis of biologically active natural products (+)‐kotanin, (−)‐isoschizandrin and (+)‐gossypol.
Copper‐Catalyzed Carboxylation of Aryl Thianthrenium Salts with CO2
Authors: Tang Shibiao , Zhao Xiaobo , Yang Lidong , Li Bin , Wang Baiquan 
Published: October 2022

AbstractCarboxyl group is one of the most widely used groups in organic synthesis. Herein, an efficient copper‐catalyzed carboxylation of aryl thianthrenium salts with carbon dioxide (CO2) at room temperature has been developed. The reaction employs low loading of cuprous chloride catalyst under 1 atm CO2 and exhibits good functional group tolerance. In combination with C−H thianthrenation of aromatic hydrocarbons, this work provides an efficient method for the site‐selective C−H carboxylation of aromatic hydrocarbons. It may serve as a significant late‐stage carboxylation tool for the modification of drug molecules in the future.
Hydrogen‐Bonded Organic Framework for High‐Performance Lithium/Sodium‐Iodine Organic Batteries
Authors: Guo Chaofei. , Han Bo , Sun Weiwei. , Cao Yingnan. , Zhang Yifan. , Wang Yong 
Published: October 2022

AbstractThe rechargeable lithium/sodium‐iodine battery (Li/Na‐I2) is a promising candidate for meeting the growing energy demand. Herein, a flexible hydrogen‐bonded organic framework (HOF) linked to the Ti3C2TxMXene complex (HOF@Ti3C2Tx) has been presented for iodine loading. HOF is self‐assembled by organic monomers through hydrogen bonding interactions between each monomer. It leads to numerous cavities in HOF structure, which can encapsulate iodine through various adsorptive sites and intermolecular interactions. The unique structure of complex can accelerate the nucleation of iodine, achieve fast reaction kinetics, stabilize iodide and retard the shuttle effect, thus improving the cycling stability of I2‐based batteries. The I2/HOF@Ti3C2Txexhibits large reversible capacities of 260.2 and 207.6 mAh g−1at 0.2 C after repeated cycling for Li‐I2and Na‐I2batteries, respectively. This work can gain insights into the HOF‐related energy storage application with reversible iodine encapsulation and its related redox reaction mechanisms with Li and Na metal ions.
Hewettite ZnV6O16 ⋅ 8H2O with Remarkably Stable Layers and Ultralarge Interlayer Spacing for High‐Performance Aqueous Zn‐Ion Batteries
Authors: Zhu Kaiyue , Jiang Weikang , Wang Zhengsen , Li Weijian , Xie Weili , Yang Hanmiao , Yang Weishen 
Published: October 2022

AbstractAqueous Zn‐ion batteries (ZIBs) are promising candidates for grid‐scale energy storage because of their intrinsic safety, low‐cost and high energy‐intensity. Vanadium‐based materials are widely used as the cathode of ZIBs, especially A2V6O16 ⋅ nH2O (AVO, A=NH4+, Na, K). However, AVO suffers from serious dissolution, phase transformation and narrow gallery spacing (∼3 Å), leading to poor cycling stability and rate capability. Herein, we unveiled the root cause of the performance degradation in the AVO cathode and therefore developed a new high‐performance cathode of ZnV6O16 ⋅ 8H2O (ZVO) for ZIB. Through a method of ion exchange induced phase transformation, AVO was converted to hewettite ZVO with larger gallery spacing (∼6 Å) and more stable V6O16 layers. ZVO cathode thus constructed delivers a high capacity of 365 and 170 mAh g−1 at 0.5 and 15 A g−1, while 86 % and 70 % of its capacity are retained at 0.5 A g−1 after 300 cycles and at 15 A g−1 after 10000 cycles, substantially better than conventional AVO.
pH Dependence of Amyloid‐β Fibril Assembly Kinetics: Unravelling the Microscopic Molecular Processes
Authors: Tian Yao , Viles John H. 
Published: October 2022

AbstractCentral to Alzheimer's disease (AD) is the assembly of the amyloid‐beta peptide (Aβ) into fibrils. A reduction in pH accompanying inflammation or subcellular compartments, may accelerate fibril formation as the pH approaches Aβ’s isoelectric point (pI). Using global fitting of fibril formation kinetics over a range of pHs, we identify the impact net charge has on individual fibril assembly microscopic rate constants. We show that the primary nucleation has a strong pH dependence. The titration behaviour exhibits a mid‐point or pKa of 7.0, close to the pKa of Aβ histidine imidazoles. Surprisingly, both the secondary nucleation and elongation rate constants are pH independent. This indicates the charge of Aβ, in particular histidine protonation, has little impact on this stage of Aβ assembly. These fundamental processes are key to understanding the forces that drive the assembly of Aβ into toxic oligomers and fibrils.
Cross β Amyloid Nanotubes Demonstrate Promiscuous Catalysis in a Chemical Reaction Network via Co‐option
Authors: Roy Soumili , Chatterjee Ayan , Bal Subhajit , Das Dibyendu 
Published: October 2022

AbstractIn Darwin's warm pond rich with nutrients, lesser number of early catalytic machineries with modest capabilities were able to demonstrate promiscuity by catalyzing diverse biochemical transformations important for protometabolism. Herein, we report catalytically promiscuous amyloid‐based short peptide assemblies that could concomitantly catalyse three metabolically important yet orthogonal reactions. The surface exposed catalytic dyads featuring lysines and imidazoles were utilized for C=N condensation via dynamic covalent linkages and modulation of protonation events, respectively. Further, the peptide assemblies could promiscuously catalyse hydrolysis as well as retro‐aldol reactions, that could be co‐opted to facilitate C=N bond formation, either by a feedforward‐driven reaction network or by replenishing depleted substrates. The catalytic diversity of short peptide based promiscuous β‐sheet folds suggests their possible role in promoting the protometabolic network in early earth.
Synchronizing Two Distinct Nano‐Circular Sliding Motions in Six‐Component Machinery for Double Catalysis
Authors: Rajasekaran Vishnu Verman , Ghosh Amit , Kundu Sohom , Mondal Debabrata , Paululat Thomas , Schmittel Michael 
Published: October 2022

AbstractThe heteroleptic multi‐component double slider‐on‐deck systemDS3exhibits tight coupling of motional speed of two distinct nano‐circular sliders (k298=77 and 41 kHz) despite a 2.2 nm separation. In comparison, the single sliders inDS1andDS2move at vastly different speed (k298=1.1 vs. 350 kHz). Synchronization of the motions inDS3remains even when one slows the movement of the faster slider using small molecular brake pads. In contrast to the individualDS1andDS2systems,DS3is a powerful catalyst for a two‐step reaction by using the motion of both sliders to drive two catalytic processes.