bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-sectional survey of the Mental health and Addictions effects, Service impacts and Care needs of children, youth and families during the COVID-19 pandemic: the COVID-19 MASC study protocol
Authors: Markoulakis Roula , Khalid Maida , Da Silva Andreina , Kodeeswaran Sugy , Sinyor Mark , Cheung Amy , Redelmeier Donald , MacKillop James , Scarpitti Michael , Laird Hannah , Foot Jeanne , Levitt Anthony 
Published: October 2022

IntroductionThe COVID-19 pandemic has had a tremendous negative effect on the mental health and well-being of Canadians. These mental health challenges are especially acute among vulnerable Canadian populations. People living in Canada’s most populous province, Ontario, have spent prolonged time in lockdown and under public health measures and there is a gap in our understanding of how this has impacted the mental health system. This protocol describes the Mental health and Addictions Service and Care Study that will use a repeated cross-sectional design to examine the effects, impacts, and needs of Ontario adults during the COVID-19 pandemic.Methods and analysisA cross-sectional survey of Ontario adults 18 years or older, representative of the provincial population based on age, gender and location was conducted using Delvinia’s AskingCanadians panel from January to March 2022. Study sample was 2500 in phases 1 and 2, and 5000 in phase 3. The Alcohol, Smoking and Substance Involvement Screening Test and Diagnostic Statistical Manual-5 Self-Rated Level 1 Cross-Cutting Symptom Measure-Adult were used to assess for substance and mental health concerns. Participants were asked about mental health and addiction service-seeking and/or accessing prior to and during the pandemic. Analyses to be conducted include: predictors of service access (ie, sociodemographics, mental illness and/or addiction, and social supports) before and during the pandemic, and χ2tests and logistic regressions to analyse for significant associations between variables and within subgroups.Ethics and disseminationEthics approval was obtained from the Sunnybrook Research Ethics Board. Dissemination plans include scientific publications and conferences, and online products for stakeholders and the general public.
Cluster of symptomatic silicone oil droplets following intravitreal injections: a 1-year observational study
Authors: Sivertsen Magne Sand , Lode Heidrun Elisabeth , Gjølberg Torleif Tollefsrud , Petrovski Goran , Andersen Jan Terje , Jørstad Øystein Kalsnes , Moe Morten Carstens 
Published: October 2022

ObjectiveTo describe a cluster of symptomatic intravitreal silicone oil (SiO) droplets following intravitreal injections (IVIs) and assess the effect of switching to a SiO-free syringe.Methods and analysisObservational quality registry study of patients receiving IVI at a large Norwegian ophthalmology centre between April 2018 (start of cluster) and November 2019 (1 year after switching to SiO-free syringes). At onset, anti-vascular endothelial growth factor drugs were administered using SiO-containing insulin syringes. From November 2018, SiO-free syringes were implemented. Spontaneously reported symptomatic SiO cases were confirmed by slit-lamp examination. A follow-up interview was performed after 1 year, assessing visual complaints. The prevalence of non-symptomatic cases was assessed in a sample of 50 eyes from 50 consecutive IVI patients.ResultsAmong 13 429 IVIs, 50 eyes of 46 patients (29 women) with symptomatic intravitreal SiO droplets were identified. Forty-one patients reported floaters at regular appointments, whereas five patients contacted the department regarding symptoms between scheduled appointments. After 1 year, 34 patients (79%) still experienced floaters, 21 (49%) reported reduced symptoms and 3 (7%) reported worsened symptoms. Eighteen patients (42%) reported being bothered, and eight (18.6%) reported that their lives were negatively affected by the floaters. Among 50 non-symptomatic eyes that had received IVI during the same period, intravitreal SiO was found in 34 (68%). No cases of symptomatic intravitreal SiO droplets were identified after switching to SiO-free syringes.ConclusionSymptomatic intravitreal SiO following IVI can cause significant and prolonged distress for affected patients. It can be avoided by using SiO-free syringes.
Response of growth performance, blood hematology, organ indexes, and myofiber traits to increasing dietary methionine levels in Jilin White goose
Authors: Dang De Xin , Cui Yan , Zhou Haizhu , Lou Yujie , Li Desheng 
Published: October 2022

A total of 240 geese (28 days old; 120 ganders and 120 gooses) with an average initial body weight of 1068.19 ± 6.59 g were used to evaluate the effects of increasing dietary methionine (Met) levels on growth performance, blood hematology, organ indexes, and myofiber traits. The experimental period was 42 days. All birds were randomly assigned to four treatment groups based on the initial body weight. There were six replicate cages per treatment, and 10 geese per cage (5 ganders and 5 gooses). Dietary treatments were based on a basal diet containing 0.25% Met, and extra supplied 0.25%, 0.50%, and 0.75% Met to form different dietary groups (0.25%, 0.50%, 0.75%, and 1.00% Met, as-fed basis). The results of this study indicated that final body weight, body weight gain, and feed efficiency increased quadratically, relative weight of breast muscle and myofiber diameter increased cubically, serum total protein and uric acid concentrations, relative weight of liver and abdominal fat, and myofiber diameter increased linearly, whereas myofiber density decreased linearly, with the level of Met increased. The maximized growth performance and breast muscle parameters were observed in 0.75% Met-containing group.
First evaluation of a novel ionisation chamber for thermal neutron beam monitoring
Authors: Maulerová Vendula , Kanaki Kalliopi , Klein Martin , Schmidt Christian J. , Kadletz Peter M. , Laloni Alessio , Hall-Wilton Richard J. 
Published: October 2022

AbstractThe European Spallation Source ERIC (ESS), currently under construction in Lund, Sweden is a facility established to deliver the highest integrated neutron flux originating from a pulsed source with the aim of supporting an initial fifteen neutron instruments for cutting edge science experiments. This in turn requires reliable monitoring at complex neutron beam lines: in particular, linearity, timing capability, adaptability of the design for various flux ranges (dynamic range) and sensitivity to neutrons within the range of 0.6-10Å are expected from the neutron beam monitors to be installed at the ESS beam lines. Additionally, operational stability and low attenuation are also desirable characteristics for such neutron beam monitoring. A prototype neutron beam monitor based on the ionisation chamber principle and a boron converter, designed by CDT CASCADE Detector Technologies GmbH and ESS, has been investigated at the BER-II research reactor of Helmholtz Zentrum Berlin (HZB). The effort to design and investigate a thermal neutron ionisation beam monitor was initiated by adapting the concept of ionisation chambers previously known elsewhere. So far all the characterised neutron beam monitors discriminate neutron hits on a discrete event basis (pulse mode), whereas the beam monitor prototype introduced in this paper estimates the total flux as a function of current (current mode). While most other neutron beam monitoring devices and detectors rely upon a signal amplifying gain stage, the ionisation chamber operates without any gain and is consequently robust against typical detector ageing effects that compromise the sensitivity over time. The initial tests were performed at the ESS V20 test beam line under realistic conditions resembling those of the future pulses of ESS. The linearity is demonstrated for 3Å pulses in the flux range of 2-3 × 105 n/s/cm2 and for white pulses (0.6-10Å) in the range of 1-5 × 106 n/s/cm2. The timing behaviour resembles the data previously recorded at the V20 beam lines. This novel implementation of a neutron sensitive ionisation chamber shows great promise for beam monitoring and diagnostics at ESS. As the ionisation beam monitor itself is an entirely passive device, it is adequately robust to be employed in areas of high irradiation where no regular servicing or maintenance can be provided.
A Systematic Review of the Sensory Outcomes of a Standard Cross-Finger Flap Reconstruction for Fingertip Defects
Authors: CHAKRABORTY Sourabh S. , ACHARYA Sudeshna , GOEL Akhil D. , SAHU Ranjit K. , MIDYA Manojit , KOTU Suresh 
Published: October 2022

Background: The standard (dorsal) cross-finger flap (CFF) is one of the common flaps used for fingertip reconstruction. There is little consensus regarding the sensory outcomes associated with this flap. In this systematic review, we evaluated objective sensory outcome parameters of patients who underwent CFF reconstruction. Methods: This systematic review is reported using the PRISMA protocol and was registered with the International Prospective Register of Systematic Reviews. Literature search was done using the terms ‘cross-finger flap’, ‘heterodigital’, ‘finger-tip’ and ‘transdigital’. Data regarding the number of patients, follow-up duration and sensory outcomes, including 2-point discrimination (2-PD) were extracted from included studies. The analysis was performed using Microsoft Excel with MetaXL add-in software. Certainty assessment and summary of findings table was created using GRADEpro GDT. Results: This review includes 14 studies with 301 patients. We found a statistically significant difference in static 2-PD of recipient and control fingers (pooled weighted mean difference [WMD]: 1.66; 95%CI: 0.03, 3.29; p = 0.00; I2=92%, n = 7 studies). Conclusions: Dorsal CFF reconstruction for fingertip defect does not provide adequate sensory recovery. Level of Evidence: Level III (Therapeutic)
Atypical Ulnar Fracture in an Older Woman with Osteoporosis with a Five-Year History of Denosumab Treatment: A Case Report
Authors: OKUBO Naoki , YOSHIDA Takashi , OHARA Masato , TAKAHASHI Kenji 
Published: October 2022

Atypical ulnar fracture (AUF) is a rare condition that may occur in patients treated with bisphosphonates. We describe the clinical course of a patient who had an AUF during treatment with denosumab. An 86-year-old woman treated with denosumab for 5 years experienced a complete transverse fracture of the proximal left ulna after falling from a standing height. Intraoperative photographs showed cortical thickening around the fracture site. Therefore, we diagnosed the patient with AUF and performed internal fixation with a locking plate. However, a re-fracture occurred 2.5 months after surgery, which was treated with locking plate replacement with a longer one with a bone graft. One year after the second surgery, the fracture healed. To our knowledge, this is the second case report of an AUF occurring during denosumab treatment. Our case highlights the importance of careful follow-up of patients receiving not only bisphosphonate, but also denosumab. Levels of Evidence: Level V (Therapeutic)
Pessimistic Decision-Making for Recommender Systems
Authors: Jeunen Olivier , Goethals Bart 
Published: October 2022

Modern recommender systems are often modelled under the sequential decision-making paradigm, where the systemdecideswhich recommendations to show in order to maximise some notion of either imminent or long-term reward. Such methods often require an explicit model of the reward a certain context-action pair will yield – for example, the probability of a click on a recommendation. This common machine learning task is highly non-trivial, as the data-generating process for contexts and actions can be skewed by the recommender system itself. Indeed, when the deployed recommendation policy at data collection time does not pick its actions uniformly-at-random, this leads to a selection bias that can impede effective reward modelling. This in turn makes off-policy learning – the typical setup in industry – particularly challenging. Existing approaches for value-based learning break down in such environments.In this work, we propose and validate a generalpessimisticreward modelling approach for off-policy learning in recommendation. Bayesian uncertainty estimates allow us to express scepticism about our own reward model, which can in turn be used to generate a conservative decision rule. We show how it alleviates a well-known decision making phenomenon known as the Optimiser’s Curse, and draw parallels with existing work on pessimistic policy learning. Leveraging the available closed-form expressions for both the posterior mean and variance when a ridge regressor models the reward, we show how to apply pessimism effectively and efficiently to an off-policy recommendation use-case. Empirical observations in a wide range of simulated environments show that pessimistic decision-making leads to a significant and robust increase in recommendation performance. The merits of our approach are most outspoken in realistic settings with limited logging randomisation, limited training samples, and larger action spaces. We discuss the impact of our contributions in the context of related applications like computational advertising, and present a scope for future research based on hybrid off-/on-policy bandit learning methods for recommendation.
Intraoperative Analgesia with Magnesium Sulfate versus Remifentanil Guided by Plethysmographic Stress Index in Post-Bariatric Dermolipectomy: A Randomized Study
Authors: Silva Filho S. E. , Dainez S. , Gonzalez M. A. M. C. , Angelis F. , Vieira J. E. , Sandes C. S. 
Published: October 2022

Background. Magnesium sulfate reduces pain scores and analgesic consumption. Its use as an analgesic resource in opioid-free or opioid-sparing techniques have also been tested. The evaluation of the antinociceptive potency of drugs and doses indirectly, through hemodynamic oscillations has been questioned. A relatively new algorithm called the plethysmographic stress index has been considered sensitive and relatively specific as a parameter for assessing the need for intraoperative analgesia. Objectives. The aim of this trial was to assess the intraoperative analgesic capacity of magnesium sulfate compared to remifentanil. The secondary objectives were propofol consumption and its latency, the consumption of opioids, ephedrine, and cisatracurium. Patients and Methods. Forty patients scheduled for post-bariatric dermolipectomy were randomly assigned to two groups to receive total intravenous anesthesia with target-controlled hypnosis induced with propofol. Analgesia was obtained in the remifentanil group with remifentanil at an initial dose of 0.2 μg·kg−1·min−1 and in the magnesium sulfate group with magnesium sulfate 40 mg·kg−1 + 10 mg·kg−1·h−1. Results. There was no statistical hemodynamic difference between the groups before and after orotracheal intubation (

p

= 0.062) and before and after the surgical incision (

p

= 0.656). There was also no statistical difference in the variation of mean arterial pressure before and after intubation (

p

= 0.656) and before and after the surgical incision (

p

= 0.911). There was similar consumption of cisatracurium, ephedrine, and postoperative opioids between the groups. Some patients in the magnesium sulfate group needed more intraoperative fentanyl and propofol, although the latency of propofol was similar in both the groups. Conclusion. We conclude that using magnesium sulfate in intravenous general anesthesia for post-bariatric dermolipectomy is related to a significant reduction in opioid consumption without compromising hemodynamic stability. Overall, PSI monitoring was helpful in driving the analgesic strategy. The use of magnesium sulfate proved to be an important adjunct in the scenario presented, allowing the use of opioids to be avoided in certain cases. We found no statistical differences in the consumption of neuromuscular blocker and vasoconstrictor. Substituting opioids for magnesium sulfate leads to an increase in propofol consumption in the scenario presented. Studies with a larger sample are needed to corroborate the results presented and evaluate other potential advantages in reducing opioid consumption.
Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells
Authors: Zhang Weijie , Xu Zhan , Hao Xiaoxin , He Tiancheng , Li Jiasong , Shen Yichao , Liu Kai , Gao Yang , Liu Jun , Edwards David G. , Muscarella Aaron M. , Wu Ling , Yu Liqun , Xu Longyong , Chen Xi , Wu Yi-Hsuan , Bado Igor L. , Ding Yunfeng , Aguirre Sergio , Wang Hai , Gugala Zbigniew , Satcher Robert L. , Wong Stephen T.C. , Zhang Xiang H.-F. 
Published: October 2022

Abstract

The bone microenvironment is dynamic and undergoes remodeling in normal and pathologic conditions. Whether such remodeling affects disseminated tumor cells (DTC) and bone metastasis remains poorly understood. Here, we demonstrated that pathologic fractures increase metastatic colonization around the injury. NG2+ cells are a common participant in bone metastasis initiation and bone remodeling in both homeostatic and fractured conditions. NG2+ bone mesenchymal stem/stromal cells (BMSC) often colocalize with DTCs in the perivascular niche. Both DTCs and NG2+ BMSCs are recruited to remodeling sites. Ablation of NG2+ lineage impaired bone remodeling and concurrently diminished metastatic colonization. In cocultures, NG2+ BMSCs, especially when undergoing osteodifferentiation, enhanced cancer cell proliferation and migration. Knockout of N-cadherin in NG2+ cells abolished these effects in vitro and phenocopied NG2+ lineage depletion in vivo. These findings uncover dual roles of NG2+ cells in metastasis and remodeling and indicate that osteodifferentiation of BMSCs promotes metastasis initiation via N-cadherin–mediated cell–cell interaction.

Significance:
The bone colonization of cancer cells occurs in an environment that undergoes constant remodeling. Our study provides mechanistic insights into how bone homeostasis and pathologic repair lead to the outgrowth of disseminated cancer cells, thereby opening new directions for further etiologic and epidemiologic studies of tumor recurrences.
This article is highlighted in the In This Issue feature, p. 247
Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study
Authors: Smith Hadley Stevens , Sanchez Clarissa E. , Maag Ronald , Buentello Alexandria , Murdock David R. , Metcalf Ginger A. , Hadley Trevor D. , Riconda Daniel L. , Boerwinkle Eric , Wehrens Xander H.T. , Ballantyne Christie M. , Gibbs Richard A. , McGuire Amy L. , Pereira Stacey 
Published: October 2022

Background:
Routine genome-wide screening for cardiovascular disease risk may inform clinical decision-making. However, little is known about whether clinicians and patients would find such testing useful or acceptable within the context of a genomics-enabled learning health system.

Methods:
We conducted surveys with patients and their clinicians who were participating in the HeartCare Study, a precision cardiology care project that returned results from a next-generation sequencing panel of 158 genes associated with cardiovascular disease risk. Six weeks after return of results, we assessed patients’ and clinicians’ perceived utility and disutility of HeartCare, the effect of the test on clinical recommendations, and patients’ attitudes toward integration of research and clinical care.

Results:
Among 666 HeartCare patients with a result returned during the survey study period, 42.0% completed a full or partial survey. Patient-participants who completed a full survey (n=224) generally had positive perceptions of HeartCare independent of whether they received a positive or negative result. Most patient-participants considered genetic testing for cardiovascular disease risk to have more benefit than risk (88.3%) and agreed that it provided information that they wanted to know (81.2%), while most disagreed that the test caused them to feel confused (77.7%) or overwhelmed (78.0%). For 122 of their patients with positive results, clinicians (n=13) reported making changes in clinical care for 66.4% of patients, recommending changes in health behaviors for 36.9% of patients, and recommending to 33.6% of patients that their family members have clinical testing.

Conclusions:
Both patients and clinicians thought the HeartCare panel screen for cardiovascular disease risk provided information that was useful in terms of personal or health benefits to the patient and that informed clinical care without causing patients to be confused or overwhelmed. Further research is needed to assess perceptions of genome-wide screening among the US cardiology clinic population.
Health of the Food Environment Is Associated With Heart Failure Mortality in the United States
Authors: Gondi Keerthi T. , Larson John , Sifuentes Aaron , Alexander Neil B. , Konerman Matthew C. , Thomas Kali S. , Hummel Scott L. 
Published: October 2022

Background:
Food environment factors contribute to cardiovascular disease, but their effect on population-level heart failure (HF) mortality is unclear.

Methods:
We utilized the National Vital Statistics System and USDA Food Environment Atlas to collect HF mortality rates (MR) and 2 county food environment indices: (1) food insecurity percentage (FI%) and (2) food environment index (FEI), a scaled index (0–10, 10 best) incorporating FI% and access to healthy food. We used linear regression to estimate the association between food environment and HF MR

Results:

Mean county FI% and FEI were 13% and 7.8 in 2956 included counties. Counties with FI% above the national median had significantly higher HF MR (30.7 versus 26.7 per 100 000;
P
<0.001) compared with FI% below the national median. Counties with HF MR above the national median had higher FI%, lower FEI, lower density of grocery stores, poorer access to stores among older adults, and lower Supplemental Nutrition Assistance Program participation rate (
P
<0.001 for all). Lower county FI% (β=−1.3% per 1% decrease) and higher county FEI (β=−3.6% per 1-unit increase in FEI) were significantly associated with lower HF MR after adjustment for county demographic, socioeconomic, and health factors. This association was stronger for HF MR compared with non-HF cardiovascular disease MR and all-cause MR The relationship between food environment and HF MR was stronger in counties with the highest income inequity and poverty rate.

Conclusions:
Healthier food environment is significantly associated with lower HF mortality at the county level. This reinforces the role of food security on cardiovascular outcomes.
A phylogenetic study of the relationships within Mirinae subfamily (Insecta: Heteroptera: Miridae) based on specimens from Northern Iran: Insight into analyses of genera complexes
Authors: ZAMANI MOZHGAN , HOSSEINI REZA 
Published: October 2022

A phylogenetic analysis of the subfamily Mirinae was conducted based on 89 external and genitalic morphological characters. Forty-six species belonging to 30 genera were coded and phylogenetic analysis reconstructed using un-weighted (EW) and implied weighted (IW) characters in a parsimony analysis. This resulted in the monophyly of eight genera including Stenodema, Polymerus, Orthops, Lygus, Phytocoris, Adelphocoris, Grypocoris and Brachycoleus, the ACM (Adelphocoris, Creontiades, Megacoelum) complex, Closterotomus, Calocoris and Lygus complexes. The phylogenetic relationships and supporting morphological characters are discussed. The taxonomic status of Pseudomegacoelum irbilanum was evaluated. Scanning electron micrographs, drawings of genitalic structures, digital images of the habitus of selected species are presented to illustrate characteristic features. This study is the first attempt to analyze the phylogenetic relationship of plant bugs in Iran.