bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of nonpharmacological interventions on pain and sleep quality after percutaneous nephrolithotomy
Authors: Fu Shibao , Mo Zhibo , He Shuming , Che Xianping , Wu Tingming 
Published: April 2022

Abstract

Background:
Various nonpharmacological interventions have been applied to alleviate pain and improve sleep quality after percutaneous nephrolithotomy. However, evidence to compare their efficacy is scant. This study aims to evaluate the efficacy of different nonpharmacological interventions on alleviating pain and improving sleep quality in patients after percutaneous nephrolithotomy through a network meta-analysis .

Methods:
Randomized controlled trials reporting the efficacy of nonpharmacological interventions on alleviating pain and improving sleep quality in patients after percutaneous nephrolithotomy will be searched in online databases, including the Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, Wanfang, China Biomedical Literature Database, Pubmed, Web of Science, Embase, and Cochrane Library. After quality assessment and date extraction, network meta-analysis will be performed using Stata 14.0 and R software.

Results:
The results of this meta-analysis will be submitted to a peer-reviewed journal for publication.

Conclusions:
This study will provide systematic and comprehensive evidence-based support for the effects of nonpharmacological interventions on alleviating pain and improving sleep quality after percutaneous nephrolithotomy.

Ethics and dissemination:
Ethical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms.

REGISTRATION NUMBER:
DOI 10.17605/OSF.IO/B4DHW.
A case report of tumor lysis syndrome after stage-one ALPPS
Authors: Cheung Ho Hung , She Wong Hoi , Yap Desmond Y.H. , Tsang Simon H.Y. , Cheung Tan To 
Published: April 2022

Abstract

Rationale:
Tumor lysis syndrome is a potentially lethal condition caused by rapid cell death, releasing a high level of toxic cytokines. It is common in patients with hematological malignancy but rare in solid tumors.

Patient concerns:
A 64-year-old patient presented to our unit with a 17.3-cm hepatocellular carcinoma and marginal liver reserve. The first-stage operation of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) was performed.

Diagnosis:
The patient was found to be anuric with grossly deranged electrolytes after the first-stage operation. Tumor lysis syndrome was diagnosed.

Interventions:
The patient was transferred to the intensive care unit for aggressive fluid administration and continuous venovenous hemofiltration for the management of tumor lysis syndrome.

Outcomes:
The patient recovered and then underwent the second-stage operation of ALPPS with extended right hepatectomy 8 days after the initial operation without any long-term sequelae.

Lessons:
ALPPS is a relatively new technique in liver surgery, entailing an increased risk of tumor lysis syndrome due to an in situ tumor after the first-stage operation. Clinicians should have a high index of suspicion regarding this potentially lethal complication with prompt management.
Bone Scan With SPECT/CT Demonstrated C1 to C2 Involvement in Rheumatic Arthritis
Authors: Chuang Tzyy-Ling , Chou Shih-Chin , Chen Yu-Ruei , Wang Yuh-Feng 
Published: April 2022

Abstract
An 80-year-old man was treated with rituximab for active rheumatoid arthritis until 2019, now controlled with Salazopyrin, prednisolone, methotrexate, and folic acid. However, laboratory data showed elevated C-reactive protein and erythrocyte sedimentation rate. Whole-body bone scan showed bony and joint destruction to the upper cervical vertebra (C spine), bilateral shoulders, wrists, finger joints, ankles, and left knee. SPECT/CT localized the upper C spine uptake to the C1/C2 joint and adjacent C1 and C2 with C1/C2 subluxation. C spine CT showed vertical atlantoaxial subluxation and bony erosions.
18F-FDG PET/CT During Neoadjuvant Targeted Therapy in Prior Unresectable Stage III Melanoma Patients
Authors: van der Hiel Bernies , Blankenstein Stephanie A. , Aalbersberg Else A. , Wondergem Maurits , Stokkel Marcel P.M. , van de Wiel Bart A. , Klop W. Martin C. , van Akkooi Alexander C.J. , Haanen John B. 
Published: April 2022

Purpose
The aim of this study was to investigate whether 18F-FDG PET/CT can predict histopathological response or recurrence in BRAF-mutated unresectable locally advanced stage III melanoma treated with neoadjuvant BRAF/MEK inhibition followed by resection and the value of PET in detecting early recurrence after resection.

Patients and Methods
Twenty BRAF-mutated, unresectable stage III melanoma patients received BRAF/MEK inhibitors before surgery. 18F-FDG PET/CT was performed at baseline and 2 and 8 weeks after initiation of therapy. After resection, PET/CT was performed at specific time points during 5 years of follow-up. Pathological response was assessed on the dissection specimen. Response monitoring was measured with SUVmax, SUVpeak, MATV, and TLG and according to EORTC and PERCIST criteria.

Results
Pathological response was assessed in 18 patients. Nine patients (50%) had a pathologic complete or near-complete response, and 9 (50%) had a pathologic partial or no response. EORTC or PERCIST response measurements did not correspond with pathologic outcome. SUVmax, SUVpeak, MATV, and TLG at all time points and absolute or percentage change among the 3 initial time points did not differ between the groups.
During follow-up, 8 of 17 patients with R0 resection developed a recurrence, 6 recurrences were detected with imaging only, 4 of which with PET/CT in less than 6 months after surgery. PET parameters before surgery did not predict recurrence.

Conclusions
Baseline 18F-FDG PET or PET response in previous unresectable stage III melanoma patients seems not useful to predict pathologic response after neoadjuvant BRAF/MEK inhibitors treatment. However, PET/CT seems valuable in detecting recurrence early after R0 resection.
PET/CT Ultrasound Fusion for Percutaneous Biopsy
Authors: Beutler Bryce David , Whang Gilbert , Tchelepi Hisham 
Published: April 2022

Purpose
The aim of this study was to assess the diagnostic yield and complication rate of 18F-FDG PET/CT ultrasound (US) fusion for percutaneous biopsy of FDG-avid lesions among patients with known or suspected malignancy.

Patients and Methods
We describe the clinical, imaging, and histopathologic features of 36 patients who underwent percutaneous biopsy using real-time PET/CT US fusion. In addition, we review the literature on PET/CT US fusion. Using Medline, the following MeSH terms were searched and relevant citations assessed: “fusion imaging,” “PET/CT fusion,” “PET/CT-guided biopsy,” “PET/US fusion,” “ultrasound fusion,” and “ultrasound fusion-guided biopsy.”

Results
A total of 36 patients (15 men, 21 women) with known or suspected malignancy and prior PET/CT imaging underwent percutaneous biopsy of FDG-avid lesions using PET/CT US fusion between October 2014 and July 2020. Coregistration was achieved using General Electric LOGIQ E9 software. Adequate tissue for analysis was obtained in all 36 patients. Histologic evaluation revealed malignancy in 14 patients (38.9%) and nonneoplastic tissue in 22 patients (61.1%). No intraprocedural or postprocedural complications were recorded.

Conclusions
Fusion of PET/CT and US for percutaneous biopsy of FDG-avid lesions can be used to achieve excellent diagnostic yield with a low risk of complications.
Intense 68Ga-PSMA Uptake in Neurofibroma Mimicking Cutaneous Metastases in a Patient With Prostate Cancer
Authors: Erol Fenercioğlu Özge , Beyhan Ediz , Leblebici Cem , Arslan Esra , Çermik Tevfik Fikret 
Published: April 2022

Abstract
Prostate cancer is the most common cancer in men. 68Ga-PSMA PET/CT is frequently used in staging and restaging prostate cancer; it is important to keep in mind the causes of false-positives when evaluating imaging. We present findings of 68Ga-PSMA PET/CT and histopathological features of a 68-year-old prostate cancer man with neurofibroma. 68Ga-PSMA PET/CT showed intense 68Ga-PSMA uptake in neurofibroma.
Nanostructure of the desmosomal plaque
Authors: Iachina Irina , Gam-Hadberg Helle , Brewer Jonathan R. 
Published: April 2022

AbstractDesmosomes are considered one of the most important intercellular junctions with respect to mechanical strength. Therefore, their spatial distribution and structure is of interest with respect to understanding both healthy and diseased tissue. Previous studies have imaged desmosomes in tissue slices using transmission electron microscopy, or low-resolution confocal images, but both these techniques lack the ability to resolve the 3-dimensional structure of the desmosomes. In this work it was possible to determine the 3D-nanostructure of single desmosomal complexes in both mouse and human epidermis, by 3D stimulated emission depletion (STED) microscopy. STED images of desmoplakin and the desmosomal cadherin, desmoglein revealed that desmosomes form ring-like structures, distributed over the cell surface, with diameters of around 1 μm. STED images of the tight junction plaque protein ZO1 also displayed ring formations, suggesting a common structure for intercellular junctions. Measurements of the desmosomal plaque protein, desmoplakin showed an increased intercellular plaque distance during the stratum basale (0.23±0.027µm) to stratum spinosum (0.28±0.039 µm) transition.
Estimated effectiveness of vaccines and extended half-life monoclonal antibodies against respiratory syncytial virus (RSV) hospitalizations in young children
Authors: Zheng Zhe , Weinberger Daniel M. , Pitzer Virginia E. 
Published: April 2022

AbstractSeveral vaccines and extended half-life monoclonal antibodies (mAbs) against RSV infection have shown promising progress in clinical trials. Aiming to project the impact of various prevention strategies against RSV hospitalizations in young children, we applied age-structured transmission models to evaluate prevention strategies including maternal immunization, live-attenuated vaccines, and long-lasting mAbs. Our results suggest that maternal immunization and long-lasting mAbs are highly effective in preventing RSV hospitalizations in infants under 6 months of age, averting more than half of RSV hospitalizations in neonates. Live-attenuated vaccines could reduce RSV hospitalizations in vaccinated age groups and are also predicted to have a modest effect in unvaccinated age groups because of disruptions to transmission. A seasonal vaccination program at the country level at most provides a minor advantage regarding efficiency. Our findings highlight the substantial public health impact that upcoming RSV prevention strategies may provide.
The estrogen receptor α cistrome in human endometrium and epithelial organoids
Authors: Hewitt Sylvia C , Wu San-pin , Wang Tianyuan , Ray Mita , Brolinson Marja , Young Steven L. , Spencer Thomas E. , DeCherney Alan , DeMayo Francesco J 
Published: April 2022

AbstractContextEndometrial health is impacted by molecular processes that underlie estrogen responses.ObjectiveTo define estrogen regulation of endometrial function by integrating the estrogen receptor alpha (ESR1) cistrome and transcriptome of endometrial biopsies taken from the proliferative and midsecretory phases of the menstrual cycle and hormonally stimulated endometrial epithelial organoids.DesignESR1 ChIPseq and RNAseq were performed on proliferative or mid-secretory endometrial biopsies and on hormone treated organoid cultures.SettingEndometrial samples were obtained from volunteers at outpatient research clinics for ChIPseq and for organoid culture.Patients or Other ParticipantsParticipants were fertile, reproductive aged women with normal cycle length, and without any history of infertility or irregular cycles. In total, 5 new endometrial biopsies obtained from 5 women were used in this study and were analyzed together with previously published cycle stage endometrial RNAseq data.Intervention(s)There were no interventions in this study.Main Outcome Measure(s)The cycle stage specific ESR1 binding sites and gene expression identification of human endometrium and organoid cultures were integrated with changes in gene expression.ResultsGenes with ESR1 binding in whole endometrium were enriched for chromatin modification and regulation of cell proliferation. The distribution of ESR1 binding sites in organoids was more distal to the gene promoter when compared to primary endometrium. Organoid estrogen/ESR1 candidate target genes impacted formation of cellular protrusions, and chromatin modification,ConclusionsAnalysis of the ESR1 cistromes and transcriptomes from endometrium and organoids provides important resources for understanding how estrogen impacts endometrial health and function.
Chaotic dynamics in spatially distributed neuronal networks generate population-wide shared variability
Authors: Mosheiff Noga , Ermentrout Bard , Huang Chengcheng 
Published: April 2022

AbstractNeural activity in the cortex is highly variable in response to repeated stimuli. Population recordings across the cortex demonstrate that the variability of neuronal responses is shared among large groups of neurons and concentrates in a low dimensional space. However, the source of the populationwide shared variability is unknown. In this work, we analyzed the dynamical regimes of spatially distributed networks of excitatory and inhibitory neurons. We found chaotic spatiotemporal dynamics in networks with similar excitatory and inhibitory projection widths, an anatomical feature of the cortex. The chaotic solutions contain broadband frequency power in rate variability and have distancedependent and low-dimensional correlations, in agreement with experimental findings. In addition, rate chaos can be induced by globally correlated noisy inputs. These results suggest that spatiotemporal chaos in cortical networks can explain the shared variability observed in neuronal population responses.
Activation of IP10/CXCR3 signaling with highly coincidental with PrPScdeposit in the brains of scrapie infected mice
Authors: Chen Jia , Chen Cao , Hu Chao , Yang Wei , Wang Lin , Chen Dong-Dong , Wu Yue-Zhang , Shi Qi , Dong Xiao-Ping 
Published: April 2022

AbstractActivation of chemokine IP10, also named as CXCL10, and its receptor CXCR3 in CNS is described in some neurodegenerative diseases. Our previous study has also demonstrated an increased brain IP10 levels in several scrapie infected rodent models. However, the detailed alteration of IP10/CXCR3 signaling in CNS during prion infection remains unsettled. Here, we found the increased IP10 signals in the brains of scrapie infected mice mainly localized in the neurons and the activated microglia using various methodologies. The levels of CXCR3 were markedly increased in brains of the scrapie infected mice and in the prion infected cell line SMB-S15. The increased CXCR3 mainly distributed in neurons. Obviously morphological colocalizations of PrP/PrPScwith IP10 and CXCR3 in the brains of scrapie infected mice were observed in the assays of immunohistochemistry (IHC) and immunofluorescence. Additionally, IHC analysis with whole brain sections demonstrated that the increased IP10 and CXCR3 accumulated in the brain regions with more PrPScdeposits. Co-immunoprecipitation and biomolecular interaction assays identified the evidence for the molecular interactions of PrP with IP10 and CXCR3. Compared to the normal partner cell line SMB-PS, the more portion of IP10 accumulated insides of prion infected SMB-S15 cells. Removal of prion replication in SMB-S15 cells by resveratrol converted the pattern of the accumulation and secretion of cellular IP10. Our data here demonstrate an activation of IP10/CXCR3 signaling in the brain tissues of prion infection, highly coincidental with PrPScdeposit. Modulation of brain IP10/CXCR3 signaling is potential therapeutic target for reducing the progression of prion diseases.
Environmental DNA persistence and fish detection in captive sponges
Authors: Cai Wang , Harper Lynsey R. , Neave Erika F. , Shum Peter , Craggs Jamie , Arias María Belén , Riesgo Ana , Mariani Stefano 
Published: April 2022

AbstractLarge and hyper-diverse marine ecosystems pose significant challenges to biodiversity monitoring. While environmental DNA (eDNA) promises to meet many of these challenges, recent studies suggested that sponges, as ‘natural samplers’ of eDNA, could further streamline the workflow for detecting marine vertebrates. However, beyond pilot studies demonstrating the ability of sponges to capture eDNA, little is known about the journey of eDNA particles in the sponge tissues, and the effectiveness of the latter compared to water samples. Here, we present the results of a controlled aquarium experiment to examine the persistence and detectability of eDNA from three encrusting sponge species and how these compare with established water filtration techniques. Our results indicate that sponges and water samples have highly similar detectability for fish of different sizes and abundances, but different sponge species exhibit considerable variance in performance. Interestingly, one sponge appeared to mirror the eDNA degradation profile of water samples, while another sponge retained eDNA throughout the experiment. A third sponge yielded virtually no DNA sequences at all. Overall, our study suggests that some sponges will be suitable as natural samplers, while others will introduce significant problems for laboratory processing. We suggest that an initial optimization phase will be required in any future studies aiming to employ sponges for biodiversity assessment. With time, factoring in technical and natural accessibility, it is expected that specific sponge taxa may become the ‘chosen’ natural samplers in certain habitats and regions.
Genomic profiling of climate adaptation in Aedes aegypti along an altitudinal gradient in Nepal indicates non-gradual expansion of the disease vector
Authors: Kramer Isabelle Marie , Pfenninger Markus , Feldmeyer Barbara , Dhimal Meghnath , Gautam Ishan , Shreshta Pramod , Baral Sunita , Phuyal Parbati , Hartke Juliane , Magdeburg Axel , Groneberg David A. , Ahrens Bodo , Müller Ruth , Waldvogel Ann-Marie 
Published: April 2022

AbstractBackgroundDriven by globalization, urbanization and climate change, the distribution range of invasive vector species has expanded to previously colder ecoregions. To reduce health-threatening impacts on humans, insect vectors are extensively studied. Population genomics can reveal the genomic basis of adaptation and help to identify emerging trends of vector expansion.ResultsBy applying whole genome analyses and genotype-environment associations to populations of the main dengue vector Ae. aegypti, sampled along an altitudinal temperature gradient in Nepal (200- 1300m), we identify adaptive traits and describe the species’ genomic footprint of climate adaptation to colder ecoregions. We found two clusters of differentiation with significantly different allele frequencies in genes associated to climate adaptation between the highland population (1300m) and all other lowland populations (≤ 800 m). We revealed non-synonymous mutations in 13 of the candidate genes associated to either altitude, precipitation or cold tolerance and identified an isolation-by-environment differentiation pattern.ConclusionOther than the expected gradual differentiation along the altitudinal gradient, our results reveal a distinct genomic differentiation of the highland population. This finding either indicates a differential invasion history to Nepal or local high-altitude adaptation explaining the population’s phenotypic cold tolerance. In any case, this highland population can be assumed to carry pre-adapted alleles relevant for the species’ invasion into colder ecoregions worldwide that way expanding their climate niche.
An integrated framework examining sustainable green behavior among young consumers
Authors: Jahari Siti Aqilah , Hass Ashley , Idris Izian Binti , Joseph Mathew 
Published: April 2022

Purpose
Promoting sustainable behavior is an elusive task as it is not an innate and natural response of individuals. While a conducive environment that promotes sustainability arguably plays a prominent role in influencing individuals’ belief structure and norms, not much has been done to examine the interplay between environmental, personal and behavioral domains in sustainable consumption. Drawing on the theoretical perspectives of the social cognitive theory (SCT) and value–beliefs–norms (VBN), this study aims to contribute to the literature by proposing an integrated framework that examines sustainable consumption.

Design/methodology/approach
This study uses a partial least squares structural equation modeling model based on 313 young consumer responses from an eco-friendly institution in Malaysia.

Findings
The findings from this study advance sustainable literature by establishing the multidimensionality concept of the personal domain of SCT. Interestingly, an enabling environment that promotes sustainability was found to be more influential in determining young consumers’ beliefs and norms, as opposed to their competencies. This is demonstrated by the sequential mediation of attribution of responsibility and personal norms on the relationship between campus advertisements and pro-environmental behaviors.

Originality/value
Previous research has investigated SCT and VBN as two separate streams of research in examining green behaviors. To the best of our knowledge, this is the first study that integrates SCT and VBN by examining the multidimensionality aspect of the personal construct to provide a more holistic perspective of examining sustainable behaviors.
Asymmetric effect of exchange rate and investors' sentiments on stock market performance
Authors: Ghumro Niaz Hussain , Soomro Ishfaque Ahmed , Abbas Ghulam 
Published: April 2022

PurposeThis study investigates the asymmetric effects of exchange rate and investors' sentiments simultaneously on stock market performance in the United States context. In addition, we have also considered the potential effect of the global financial crisis of 2008 on this nexus.Design/methodology/approachWe have employed the NARDL (nonlinear autoregressive distributed lag) model on monthly data ranging from January-1999 to December-2018 to investigate the asymmetric (short- and long-run) effects of exchange rate and investors' sentiments on stock market performance. We have also broken down the data into two segments, pre and post-crisis periods to capture the effect of the global financial crisis of 2008.FindingsThe findings of the study reveal that exchange rate and investors' sentiments simultaneously affect stock market performance and omitting any of these variables can produce misleading results. Results also show that the effect of sentiments is stronger than the exchange rate. There is significant evidence of asymmetric short-run and long-run effects of both explanatory variables. Moreover, we have found different outcomes for pre and post-crisis periods. Specifically, the impact of macroeconomic variables on the stock market has been substantiated in the post-crisis period.Originality/valueSeveral studies are available which separately evidence the effects of investors' sentiments and exchange rate on performance of the stock market but they can suffer from the problem of omitted variable bias. This study is conducted to test the said effect simultaneously in a single model. Moreover, this study is considering short-run and long-run asymmetry in analyzing the effects of explanatory variables along with the inclusion of the global financial crisis of 2008.