bluuebunny/crossref_metadata_2025_split huggingface dataset:
circRNA DENND1B inhibits tumorigenicity of clear cell renal cell carcinoma via miR-122-5p/TIMP2 axis
Authors: Chen Deqiang , Zhang Yanchun , Meng Liang , Lu Li , Meng Gaopei 
Published: December 2022

Abstract
Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cancers. However, circ_DENND1B has not been studied yet. GSE100186 dataset was used for the level analysis of circ_DENND1B. The quantitative real-time PCR was used to verify the expression of circ_DENND1B, microRNA-122-5p (miR-122-5p) and tissue inhibitor of metalloproteinases-2 (TIMP2) in ccRCC tissues and cells. Cell proliferation, migration, invasion and apoptosis were detected by colony formation assay, thymidine analog 5-ethynyl-2′-deoxyuridine assay, 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyl tetrazolium bromide, transwell and flow cytometry. The binding of miR-122-5p to circ_DENND1B/TIMP2 was investigated by dual-luciferase reporter assay. Finally, the role of circ_DENND1B in ccRCC was detected by tumorigenesis experiment in mice. circ_DENND1B was downregulated in ccRCC and circ_DENND1B overexpression suppressed the malignant behaviors of ccRCC cells. circ_DENND1B acted as a sponge of miR-122-5p. miR-122-5p upregulation reversed the effects of circ_DENND1B on cell proliferation, migration, invasion and apoptosis. TIMP2 was a target of miR-122-5p. Overexpression of circ_DENND1B regulated TIMP2 level by inhibiting miR-122-5p expression in ccRCC cells. circ_DENND1B overexpression inhibited the tumor growth of ccRCC in vivo. circ_DENND1B inhibited ccRCC cell progression by promoting TIMP2 expression by sponging miR-122-5p, suggesting that circ_DENND1B might be an effective therapeutic target for ccRCC.
EphA3 targeted by miR-3666 contributes to melanoma malignancy via activating ERK1/2 and p38 MAPK pathways
Authors: Ming Di , Ma Jingjing 
Published: December 2022

Abstract
Melanoma is a rare, fatal type of skin tumor. Although EPH receptor A3 (EphA3) is deregulated in melanoma, its detailed role remained uncharacterized. Using real time quantitative PCR analysis and western blotting, EphA3 was identified to be upregulated in melanoma tissues and cells, while miR-3666 showed an opposite expression trend. Cell counting kit-8, scratch wound, and in vivo assays proved that EphA3 silence inhibited the melanoma cell proliferation and migration and retarded tumor growth in vivo. Furthermore, western blotting results displayed that EphA3 silence resulted in a low expression of p38-MAPK and p-ERK1/2. Mechanically, miR-3666 was proved to target EphA3 3′UTR by the luciferase reporter assay. Furthermore, miR-3666 mimic compromised the driven melanoma cell proliferation and migration by EphA3 overexpression. In addition, induction of ERK1/2 and p38 MAPK pathways offset the positive effect of EphA3 overexpression on melanoma cells. In conclusion, miR-3666 downregulated EphA3 expression and retarded melanoma malignancy via inactivating ERK1/2 and p38 MAPK pathways. Hence, miR-3666/EphA3 axis may represent a druggable target against melanoma progression.
Crystal structure of 1-(3-bromopropyl)-2-((4-chlorophenoxy)methyl)-4-methyl-1H-benzo[d]imidazole, C18H18BrClN2O
Authors: Yu Wen Ya-Huan , Zhang Pin , Liu Bin 
Published: December 2022

Abstract
C18H18BrClN2O, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 9.0583(4) Å, b = 9.2694(4) Å, c = 11.1183(4) Å, α = 83.1120(10)°, β = 72.2590(10)°, γ = 73.9400(10)°, V = 853.80(6) Å3, Z = 2, Rgt
(F) = 0.0381, wRref
(F
2) = 0.0969, T = 170 K.
Crystal structure of 1-(2-(4-chlorophenethyl)-2-hydroxy-3,3-dimethylbutyl)-1H-1,2,4-triazol-4-ium nitrate, C16H23N4O4Cl
Authors: Wang Hua , Zhang Guo-tao , Li Hong-ya 
Published: December 2022

Abstract
C16H23N4O4Cl, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 7.609(2) Å, b = 9.287(3) Å, c = 13.511(4) Å, α = 90.530(7)°, β = 102.028(5)°, γ = 97.774(6)°, V = 924.4(5) Å3, Z = 2, R
gt(F) = 0.0625, wR
ref(F
2) = 0.1634, T = 296(2) K.
Mechanisms of the improved stiffness of flexible polymers under impact loading
Authors: Chen Fengxiao , Fan Jitang , Hui David , Wang Chao , Yuan Fuping , Wu Xiaolei 
Published: December 2022

Abstract
The flexible polymers have an outstanding impact-resistant performance because of the improved stiffness upon a high speed loading. At the aspect of microstructure, the soft segments make an important contribution. In this article, molecular dynamics simulation is carried out to reveal the dynamic mechanical behavior of a mono helical soft segment. The tensile loadings at various strain rates are conducted. The stress–strain relations and strain rate dependencies of mechanical properties are derived. The evolution of potential energy with straining accompanied by the disentanglement of molecular chain is characterized. The characteristic molecular chain of dynamic mechanical response is determined. The intrinsic physical origins of straightening of characteristic molecular chain and bond angle expansion are explored. New parameters are defined to quantitatively analyze the micro mechanisms and their rate dependencies, which are linked to the dynamic mechanical properties. This work is full of interest to fill a knowledge gap of the physical origins of dynamic mechanical behavior of flexible polymers.
Evaluation of combustion characteristics performances and emissions of a diesel engine using diesel and biodiesel fuel blends containing graphene oxide nanoparticles
Authors: Pireh Meysam Eshaghi , Parashkoohi Mohammad Gholami , Zamani Davood Mohammad 
Published: December 2022

Abstract
In this study, the performance and emissions of a compression combustion diesel engine were investigated. The net diesel and the blends of diesel with waste cooking oil (WCO) biodiesel (5 and 20%) were considered as control fuel and were blended with graphene oxide nanoparticles (GONPs) (30, 60, and 90 ppm) and were evaluated. The engine was operated at full load at 1,500 rpm and the brake power (BP), brake thermal efficiency (BTE), and brake specific fuel consumption (BSFC) besides CO, CO2, and NO
x
emissions appraised in the two sections of engine performance and emission, respectively, were evaluated. According to the results in the D95B5G90 fuel blend, GONPs had a positive effect on BP. BTE also showed a significant improvement in D95B5G60. GONPs increase NO
x
and CO2 emissions and decrease CO emissions. Overall, it can be concluded that GONPs can be introduced as a suitable alternative additive for diesel and WCOs biodiesel fuel blends.
Teacher talk in primary school science: a focus on the exploration phase
Authors: Oats Megan , Exley Beryl 
Published: December 2022

Abstract
In this article, we narrow our investigation to the talk provided by one teacher in the exploration phase of a primary school science project. The exploration phase warrants attention given its role in providing students with a common base of science activities that draws on their prior knowledge. We examine lesson excerpts from a grant-winning primary years science teacher who sets up her Year 3 students to explore garden ecosystems. The study’s analytic framework is derived from Systemic Functional Linguistics and focuses on the way the teacher uses certain aspects of ideational, interpersonal and textual functions to mediate between the instructional and regulative discourses. Our findings show that the teacher orientated to the regulative discourse to provide students with access to an instructional discourse. Additionally, the teacher used a significant number of pronouns for signalling, and sequencing connectives that flowed on to a significant number of complex noun groups. We draw attention to the range of speech functions and comment on their role in school science lessons.
IMPAK FALSAFAH PASCA-KOLONIALISM TERHADAP MUZIUM: SATU ANALISIS KRITIKAL
Authors: Abd Jalal Ahmad Farid , Abdul Rahim Rahimin Affandi , Said Mohamad Hilmi Mat , Awang Pawi Awang Azman 
Published: December 2022

Abstract: The museum discipline can be considered a dynamic modern institution. This one, among other things, stems from the openness of this institution with the philosophy of post-colonialism. It is a modern humanitarian philosophy that challenges many flaws of past scientific theories. This study will use library research methods that will examine the influence of post-colonial philosophy in the field of museums. The results of this study found that there are three main things about the impact of post-colonial philosophy in the field of museums, namely the emergence of New Museum Awareness, the universal issue of museums and the issue of decolonization from the influence of colonial museums.

Abstrak: Disiplin muzium dapat dianggap sebagai institusi moden yang dinamik. Hal ini antara lainnya berpunca daripada keterbukaan institusi ini dengan falsafah pasca kolonialism. Ia adalah suatu falsafah kemanusiaan moden yang banyak mencabar kepincangan teori keilmuan silam. Kajian ini akan menggunakan kaedah penyelidikan perpustakaan yang bakal meneliti pengaruh falsafah pasca kolonialism dalam bidang muzium. Hasil kajian ini mendapati bahawa pengaruh falsafah pasca kolonialism dalam bidang muzium dapat dikesan dalam tiga perkara utama iaitu kemunculan Kesedaran Muzium Baru, isu universal muzium dan isu dekolonialisasi daripada pengaruh muzium kolonial.
The constitutional identity of the member states: False evidence or constitutive element of a new architecture of the Union?
Authors: Delcamp Alain 
Published: December 2022

AbstractThe notion of ‘identity’ once seemed perfectly obvious and applied mainly to individuals. A spectacular evolution of the notion could have been considered in recent years. In the social sciences where it was associated with the notion of group but, after having invaded the public debate, it has now reached the law domain. It now appears in the debates and even the decisions of the constitutional courts of the member states of the European Union. This is a general movement which is part of a climate in which, to varying degrees, there is expressed dissatisfaction with regard to the operation of the institutions of the Union and, more particularly, their mode of creation of law, as soon as it benefits from the principle of primacy affirmed by the Treaties.The purpose of this article is to gather and evaluate the information available through the various case law and comments, in order to better clarify the notion of constitutional identity and assess its effectiveness. The concept remains contested, and its use has not yet resulted in significant consequences, but its study is an opportunity to suggest improvements in the dialogue between the constitutional courts and the Court of Justice of the European Union; to also ask whether the notion of ‘constitutional identity’ could not be a valuable tool in redefining the relationship between the Union and the Nations that compose it.
Constitutional identity as a normative constitutional concept
Authors: Szente Zoltán 
Published: December 2022

AbstractAlthough constitutional identity is nowadays invoked by European states primarily against the extension of the powers of the EU institutions, it can also be understood as a substantive concept of national constitutional law. This article deals with constitutional identity as a normative constitutional concept. In this respect, the problem is the same as that which arises in the relationship between EU law and domestic law: namely, its fundamental indeterminacy and the possible arbitrariness of its application. The author argues that, therefore, constitutional identity can only be plausibly invoked if satisfactory answers can be given to the questions of exactly whose identity it is, what its source is, who and how its content may define, and what the constitutional function of this category is. The second part of the study examines the Hungarian constitutional identity according to this analytical framework, and concludes that, although its subject is the Fundamental Law, its definition, content and constitutional function are unclear and contradictory. Consequently, the current concept of constitutional identity in Hungary raises a number of problems for which no plausible answers have yet been found, and it is highly doubtful whether the doctrinal and practical difficulties related to it can be resolved at all.
Factors of the elderly being exposed to COVID-19: a scoping review
Authors: Indah Rahayu Asih , Huriah Titih 
Published: December 2022

Background: The world today and public health problems ahead of the pandemic respiratory syndrome or commonly called COVID-19. It is important to identify the risk, especially for mortality understanding, nutrition status of elderly and dementia. This study literature review aims to understand the risk factors of the elderly when pandemic COVID-19.Method: This literature uses the scoping review method and searches PubMed, Proquest, and Sciencedirect. Criteria for determining the literature review done using the words “Risk OR Factors OR Elderly Get OR Covid-19”. The study's inclusion criteria are articles for the last two years is 2020-2021, and the type of article includes a suitable journal, first select the title, abstract, journal content, and cohort study, chi-square cross-sectional, and case-control.Result: After these inclusion criteria based on the categories and filtered, the database is used in the journal is five literature reviews. The risk factors for the elderly exposed to COVID-19 include problems understanding COVID-19, nutritional status of problems, dementia experienced by the elderly. Conclusion: Two risk factors are often faced by the elderly during the COVID pandemic, namely problems with understanding and dementia in the elderly.
The integrated intervention of early childhood education and stunting prevention program in increasing pre-school age children's food intake
Authors: Huriah Titih , Lestari Anisyah Arum , Rahmawati Agustina , Prasetyo Yoyok Bekti 
Published: December 2022

Introduction: Indonesia's stunting rates are staggering, with more than 30% of stunted children. The government has conducted several stunting treatment programs, but the number of stunted children in Indonesia is still more than 20%. On the other hand, Indonesia has an education system for pre-school children. Stunting prevention can integrate with this system by providing nutrition education to pre-school children. The experiment aims to prevent stunting in children by integrating early childhood education and nutrition education to increase food intake.Methods: The population is pre-school-age children in Bantul Regency Yogyakarta. The research sample was 20 pre-school children given the program and 19 pre-school children in the control group. The integration program was given to children for three months (February - April 2021). The activities are education to improve children's developmental abilities and provide nutrition-related education. The food intake measuring instrument used a food recall analyzed by the Nutri-survey software. Data analysis used central tendency and t-test.Results: The average food intake was still below the Recommended Dietary Allowances (RDA), namely 1064 kcal in the intervention group and 1182 kcal in the control group. However, there was an increase in food intake in total daily food intake, breakfast intake, and dinner with a p-value of 0,001, 0,028, and 0,022, respectively, while at lunch intake, there was no difference with p-value 0,069.Conclusion: The integrated early childhood education and nutrition education programs can increase food intake for pre-school children. Therefore, this program is critical to be continued in all early childhood education systems in Indonesia as one of the stunting prevention programs.
Changes in plasma levels of IL-6 and D-dimer in high-risk thrombosis cancer patients undergoing chemotherapy
Authors: Setiawan Budi , Manurung Amelia KW , Zulizar Alif Adlan , Budianto Widi , Sukarnowati Tri Wahyu , Pangarsa Eko Adhi , Santosa Damai , Setiabudy Rahajuningsih Dharma , Suharti Catharina 
Published: December 2022

Background: Cancer and chemotherapy are venous thromboembolism (VTE) risk factors. The immune system and inflammation are essential in cancer-associated thrombosis's pathogenesis. Chemotherapy can induce inflammatory conditions that trigger the nuclear factor kappa B (NF-κB) signaling pathway to produce proinflammatory cytokines. Interleukin 6 (IL-6) improves procoagulant status primarily by inducing tissue factor (TF) expression. Tissue factor expression triggers the coagulation system, characterized by increased levels of D-dimer. This study assessed the change in plasma levels of IL-6 and D-dimer changed in high-risk thrombosis cancer patients undergoing chemotherapy.
Methods: This study was a prospective cohort study of 54 newly diagnosed high-risk thrombosis cancer patients undergoing chemotherapy in Dr. Kariadi General Hospital from January 2021 to September 2021 based on inclusion and exclusion criteria. IL-6 and D-dimer concentrations were collected a day before and after chemotherapy. IL-6 measured by ELISA method and D-dimer measured by the turbidimetry chromogenic immunoassay method. We did correlation test, compared mean, and subgroup analysis. The p-value<0.05 was significant.

Results: There was a positive correlation between plasma levels of IL-6 and D-dimer both pre- and post-chemotherapy (r=0.36; 95% CI (0.1-0.6); p=0.006 and r=0.45; 95% CI (0.2-0.6); p=<0.001, respectively). Post-chemotherapy plasma IL-6 (61.0±84.9 pg/mL) was significantly lower (p=0.022) than pre-chemotherapy (102.4±141.6 pg/mL). Subgroup analysis based on risks of thrombosis showed a significant decrease in plasma levels of IL-6 in the higher risk cancer group of thrombosis post-chemotherapy compared with the low risk cancer group (77.7±144.1 pg/mL vs -0.9±127.8 pg/mL; p=0.037). There was an increase in D-dimer plasma levels post-chemotherapy, but it was not statistically significant (2598.1±2487.8 µg/ml vs 3098.6±3547.4 µg/ml; p=0.512). The subgroup analysis based on blood type, tumor stage, chemotherapy regimen, and risk of thrombosis showed no significant differences in delta plasma IL-6 and D-Dimer levels pre- and post-chemotherapy.
Conclusion: In high-risk thrombosis cancer patients who underwent chemotherapy, there was a statistically significant decrease in plasma levels of IL-6 post-chemotherapy. There was an increase in D-dimer plasma levels post-chemotherapy, but it was not statistically significant.
The complexity of perioperative management of acute limb ischemia in elderly with multiple comorbidities and underlying diseases: A case report
Authors: Aditya Riadi Syafei  , Jusri Ichwani  , Novira Widajanti  , Hadiq Firdausi  
Published: December 2022

Background: Aging process commonly associated with multiple comorbidities such as metabolic disorders, vascular, visual, gait, balance and psycho-social problems. Atherosclerosis is one of comorbidities that could occur as a pre-existing condition in elderly with peripheral artery disease (PAD). Elderly patients associated with complex and multi-factorial medical conditions need to be addressed in a comprehensive approach. Here we report the complexity of perioperative management of an elderly with acute limb ischemia in elderly with multiple comorbidities and underlying diseases.
Case Presentation: An elderly woman, 77-year-old, was referred to emergency room due to decreased level of consciousness. There were complaints of loss appetite, inactivity, bedridden, pain, paresthesia and muscle weakness in the right lower limb. There was history of chronic hypertension and dyspepsia. Since there was a sign of right lower limb acute limb ischemia, the patient was discussed with the multi-discipline team, planned for primary amputation, and received systemic anticoagulant treatment. Due to multiple comorbidities and underlying diseases, the patient died prior to amputation surgery.
Conclusion: Surgery is not contraindication to elderly; however, from this case it shed light the needs of multi-discipline approach to decide the best treatment options for patient’s needs. Utilizing a Comprehensive Geriatric Assessment (CGA) could be an alternative to non-invasive, simple, and effective approach available in any healthcare setting.
Successful rate of glaucoma surgery in uveitis glaucoma
Authors: Elsa Gustianty  , Novaqua Yandi  , R. Maula Rifada  , Andika Prahasta  
Published: December 2022

Introduction: Glaucoma is one of the most common complications in uveitis. The surgical intervention has been known for a lower success rate in Uveitis Glaucoma (UG). However, it is still a treatment of choice when medical therapy no longer could control the intraocular pressure (IOP). This study aims to describe UG's demographic and clinical characteristics that received glaucoma surgery and the outcome.
Methods: Medical records of UG patients that received glaucoma surgery in 2018-2019 were reviewed. Age, gender, type and etiology of uveitis, duration of uveitis, intraocular pressure (IOP), visual acuity, gonioscopy, ocular characteristic, previous surgery and laser, current surgery, and complication were studied. Success was defined as IOP ≤21 mmHg or reduction >20% from baseline and >6mmHg with or without medication. Failure is defined in the presence of surgery complication that leads to a change of IOP, uncontrolled IOP that needs additional surgery, and visual acuity becomes no light perception (NLP).
Results: 48 patients (57 eyes) with UG underwent glaucoma surgery. The mean age was 47,23±14,62. Anterior uveitis was the most common type of UG, with a mean uveitis duration before surgery was 13,75±17,65 months. The mean initial IOP was 35,81±13,30 mmHg, at the final visit 15,09±3,36. The mean follow-up duration was 6,41±4,02 months. The overall partial success was 75,44% in one month, 67,74% in 6 months
Conclusion: A decrease in IOP was found in all surgery interventions, including Glaucoma Drainage Device (GDD) implant, trabeculectomy with 5-Fluorouracil (5FU), and combined trabeculectomy cataract surgery with or without 5FU, and cyclodestructive laser surgery. There was a high percentage of successful surgery but many losses to follow-up eyes in a short follow-up period.