bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of microRNAs in the development of radioresistance of prostate cancer cells (experimental study)
Authors: Makhotkin M. A. , Chebotarev D. A. , Tyutyakina M. G. , Mashkarina A. N. , Tarasov V. A. , Kogan M. I. , Chernogubova E. A. 
Published: February 2022

Background. Radiation therapy is one of the leading treatments for early and late stage prostate cancer. Radiation therapy is one of the leading treatments for early and late stage prostate cancer. The significant frequency of prostate cancer progression after radiation therapy makes it relevant to study the molecular mechanisms of the development of radioresistance, to identify prognostic markers of its development.Objective: identification and analysis of the mechanism of action of microRNAs regulating radioresistance of prostate cancer cells on the model of the androgen-independent DU145 cell line.Materials and methods. We used human prostate adenocarcinoma cell lines: DU145-hormone-independent prostate cancer cell line and DU145-RR - its radioresistant variant. Differential microRNA expression was measured in cultured DU145 and DU145-RR cells 1, 8 days after a single gamma irradiation at a dose of 4 Gy. To analyze the differential expression of microRNAs in the initial and radioresistant variants of DU145 cells, the HiSeq 2000 platform (Illumina Inc., USA) was used. The miRBase v.21 database was used to identify microRNAs. The miRTarbase 7.0 and KEGG PATHWAY databases were used for bioinformatic analysisResults. The results of the study showed that the aberrant expression of miR-101-3p, -148a-3p, -21-3p, -532-5p, -92a-3p in DU145-RR cells upregulated compared to that in DU145 cells, and miR-125b-5p, -23a-3p, -424-3p - downregulated. It has been shown that the role of these microRNAs is associated with the provision of functional interaction between DNA methyltransferases, the transcriptional regulator of the proto-oncogenic protein Myc, and PTEN phosphatase in the regulation of the activity of MAPK and PI3K protein kinase signaling cascades. Constitutive activation of these cascades leads to an increase in cell survival, migration, proliferation, and growth.Conclusion. A wide range of target genes and a significant change in the expression profiles of microRNAs in various conditions, including the transition of malignant cells to a radioresistant status, makes microRNAs promising prognostic markers of radioresistance in prostate cancer.
Представљање старих књига у Дигиталној Библиотеци Матице српске: поводом јубилеја десет година Дигиталне БМС
Authors: Драпшин Александра 
Published: February 2022

Веб-презентација Дигитална БМС постављена је на интернет 20. септембра 2011. За десет година рада, у базу података укупнo је укључено 31.555 публикација (1.746.908 страница). Данас је она једна од највећих дигиталних библиотека у Србији. Стара библиотечка грађа окупљена је у девет колекција које прате постојеће збирке Библиотеке Матице српске (БМС). Дигитализовано је 4066 примерака старих рукописних и штампаних књига. Најбројнија је колекција Српске књиге од 1801. до 1867. године, са 2741 примерком грађе. Дела Вука Стефановића Караџића бележе највише прегледа у целој дигиталној библиотеци, а међу њима се истиче Живот и обичаји народа српскога (Беч, 1867), посећено 16.185 пута. Велики број посета имају и дела Доситеја Обрадовића, Јована Рајића, Захарије Орфелина, Ђуре Даничића и других. Повезивањем дигиталне копије са електронским и штампаним каталогом, корисницима се пружају и додатне информације о културном добру. Презентација Дигитална БМС омогућила је приступ српском културном наслеђу широм света.
Komunitas Grebek Sedekah Gerakan Sosial Baru sebagai Gerakan terhadap Kepedulian Sosial
Authors: Larasati Nova 
Published: February 2022

This article aims at describing Grebed Sedekah community (community charity) of which its role is to channel sedekah (charity) from donors. This study used Gerakan Soaial Baru (New Social Movement) theory from Rajendra Singh (2010). Using descriptive qualitative approach, data were collectied using obervation and interviews. The informants were selected using purposive sampling technique. This study took place in Jember residence. The results of the study showed that gerebeg Sedekah channelled charity in the forms of social, economic, education, and environment movements. Most of the charity was targetted for sub-urban areas. This social movement has an ideology of humanism, which puts the issue of caring and social solidarity. Activities carried out include Kali/river cleaning, mass circumcision, grebeg ramadhan, grebeg qurban, free food stalls, house renovation, teaching in rural areas by relying on assistance from donors based on cooperation with social groups.Keyword: Concern, Grebek sedekah, New Social Movement, Social Solidarity
Komunitas Grebeg Sedekah adalah komunitas yang bergerak dan peduli terhadap persoalan sosial, yang dimaksudkan menympaikan sedekah orang. Sedekah yang di titipkan untuk di salurkan kepada orang lain. Sebagian besar dari kegiatan Grebeg Sedekah adalah daerah plosok, karena menurut mereka kalau dikota sudah sangat biasa karena akan sering mendapatkan bantuan dari pusat (pemerintah). Berbagai kegiatan komunitas Grebeg Sedekah sepertihalnya, di bidang pendidikan, kesehatan, sosial dan lingkungan menunjukkan bahwa pusat perhatian mereka mengarah kepada kegiatan sosial. Menjadi suatu gerakan sosial dimana mereka mencoba untuk menyadarkan dan mengingatkan masih banyak keterabaikan dan kurang mendapatkan perhatian, terutama pada masyarakat yang tinggal di daerah pelosok. Bentuk tindakan dan kesadaran individu atas terjadinya ketidak seimbangan yang terjadi dalam suatu msyarakat maupun lingkungan di sekitarnya.Kata Kunci: Grebek Sedekah, Gerakan Sosial Baru, Kepedulian, Kesetiakawanan sosial
Gerakan Sewu-Sewu Ae: Peran Nyata Pemuda Mengarungi Pandemi
Authors: Jannah Salsabilah Shofiyatul , Alamsyah Anrico , Yunarko Dika Ifanda 
Published: February 2022

This article aims at explaining Sewu-Sewu Ae movement which is held by the youth in Madiun city during the Pandemic of COVID-19. It is a movement initiated from some concerns from the youth toward what happened to society especially in the time of PPKM period. This is a participatory approach as one of the authors is a pioneer of the movement. The research objective is to analyze several fundamental values, innovations, operational systems, and evaluations in the Sewu-Sewu Ae movement. Data were collected using observation, documentation, and interviews. The results of the study found that one of the biggest challenges of the society was economic difficulty. Although government has provided solutions, the implementation was complicated by the system. Reflecting from this reality, the youth took a step to take roles on this matter. During the pandemic, philanthropy-based social movements are increasingly prevalent in several cities, for example, the "Solidaritas Pangan Jogja” which started on March 2020. In essence, every social movement has its own characteristics. Likewise Sewu-Sewu Ae which was initiated by the youth of Madiun City. This fundraising movement was channeled in a program "Melariskan UMKM", "Distribusi Paket Sembako", and the latest innovation entitled "Pasar Sewu". This movement has proven to be consistent and sustainable, so that it continues to gain support from public. Sewu-Sewu Ae is able to become a medium for surrounding community to actualize social sensitivity. Keywords: Madiun, social movement, Sewu-Sewu Ae, youth
Tulisan ini bertujuan menjelaskan tentang gerakan sosial Sewu-Sewu Ae pada masyarakat Madiun di era pandemi. Kegiatan ini merupakan gerakan sosial berbasis solidaritas sosial, yang berlandaskan pada keprihatinan pemuda terhadap realitas masyarakat di masa PPKM. Penelitian ini menggunakan paradigma kualitatif dengan pendekatan partisipatoris. Pengumpulan data dilakukan dengan menggunakan metode observasi, dokumentasi, dan juga wawancara. Hasil penelitian menemukan bahwa salah satu problematika terkini adalah kesulitan ekonomi. Kendatipun pemerintah telah memberikan solusi berupa pengadaan bantuan sosial, namun implementasinya menghadapi berbagai kendala sistem. Oleh karena itu, perlu peran nyata pemuda untuk memecahkan persoalan tersebut. Pada masa pandemi, gerakan sosial berbasis filantropi kian marak di beberapa kota. Contohnya gerakan “Solidaritas Pangan Jogja” yang dimulai sejak Maret 2020. Pada hakikatnya, setiap gerakan sosial memiliki ciri khas masing-masing. Begitu pula Sewu-Sewu Ae yang diprakarsai oleh pemuda Kota Madiun. Gerakan penggalangan dana ini disalurkan dalam bentuk program “Melariskan UMKM”, "Distribusi Paket Sembako", serta inovasi terbaru bertajuk “Pasar Sewu”. Gerakan ini terbukti konsisten dan berkelanjutan, sehingga terus memperoleh dukungan khalayak umum. Sewu-Sewu Ae mampu menjadi medium bagi masyarakat sekitar untuk mengaktualisasikan kepekaan sosial. Kata kunci: gerakan sosial, pemuda, Sewu-Sewu Ae
Inertial Effect on Oil/Water Countercurrent Imbibition in Porous Media from a Pore-Scale Perspective
Authors: Cheng Zhilin , Gao Hui , Ning Zhengfu , Wang Chen , Li Teng 
Published: February 2022

Summary
The color-gradient lattice Boltzmann (LB) method is used to investigate the inertial effect on oil/water countercurrent imbibition characteristics in a matrix-fracture system. The interplay between capillarity, fluid inertia, and viscous force during the imbibition under different viscosity ratios is delineated. Pore-scale dynamics, the interfacial front morphology, and oil recovery under the influence of fluid inertia are also elucidated. Additionally, we study the energy conversion during the imbibition displacement from the perspective of energy balance. Finally, the application of the theoretical scaling model is discussed based on the simulated data. Results show that the pore-scale events involved mainly consist of cooperative pore filling, oil expelled from large pores, and the motion of jetting-like oil clusters under high viscosity ratios. The curve of pressure difference between the fracture inlet and outlet vs. imbibition time can be regarded as a signal to discern the imbibition regime, which is taken together with the energy conversion analysis could further determine how capillarity, external pressure, and viscous dissipation contribute to water imbibition. Capillary force dominates in the cases of low viscosity ratios, and the majority of the surface energy is dissipated. The external pressure becomes increasingly significant and even governs the countercurrent imbibition as the viscosity ratio increases. Furthermore, the oil recovery, interfacial area, and fractal dimension of the nonwetting phase strongly rely on the Ohnesorge (Oh) number when the viscosity ratio is low. In contrast, the inertial effect can be neglected in the cases of high viscosity ratios. Besides, the relationship between the simulated imbibition recovery and imbibition time follows the theoretical scaling model as the external pressure is trivial. The comparable exponents fitted from different Oh numbers reveal that the inertial effect does not alter the imbibition dynamics. In sum, fluid inertia only affects the local fluid behaviors and thus the imbibition oil recovery when the viscosity ratio is low. These results could provide important implications for a range of energy-related and environmental applications, such as the evaluation of fracturing fluids loss, oil recovery by water huff n puff, microfluidic devices, and hydrological sciences.
Sampling strategy, characteristics and representativeness of the InGef research database
Authors: Ludwig Marion , Enders Dirk , Basedow Frederike , Walker Jochen , Jacob Josephine 
Published: February 2022

Abstract
ObjectivesThe aim of this study was to describe the sampling strategy as well as characteristics and the external validity of a representative sample database drawn from the German InGef research database.Study DesignThis is a retrospective cohort study using anonymized claims data for the year 2019.Methods The InGef research database is an anonymized healthcare database with longitudinal claims data from approximately 8.8 Mio insurees. A sample of four million insurees was drawn intended to be representative for the German population with respect to age, sex and region. In addition to demographic information, data on hospitalization rates, mortality rates and drug prescription rates was analysed from the InGef sample database for the year 2019 to demonstrate validity and representativeness. Corresponding national reference data were obtained from official sources.Results The distributions of sex and age were similar in the InGef sample database and Germany (proportion of women: 50.8% vs. 50.7%; mean age: 44.1 vs 43.9 years). The proportion of insurees living in the eastern part of Germany was lower in the InGef sample database (16.5% vs. 19.5 %). There was good accordance with German reference data with respect to hospitalization rates and overall mortality rates. Prescription rates for the 20 most often reimbursed drug classes were slightly higher in the InGef sample database. Conclusions The InGef sample database shows good overall agreement with the German population on measures of morbidity, mortality, and drug usage.
Mobility network reveals the impact of spatial vaccination heterogeneity on COVID‐19
Authors: Yuan Yuan , Jahani Eaman , Zhao Shengjia , Ahn Yong-Yeol , Pentland Alex 
Published: February 2022

Abstract
Mass vaccination is one of the most effective epidemic control measures. Because one's vaccination decision is shaped by social processes, the pattern of vaccine uptake tends to show strong social and spatial heterogeneity, such as urban-rural divide and clustering. Examining through network perspectives, we develop a framework for quantifying the impact of spatial vaccination heterogeneity on epidemic outbreaks. Leveraging fine-grained mobility data and computational models, we investigate two network effects---the ``hub effect'' (vaccinating mobility hubs reduces transmission) and the ``homophily effect'' (stronger homophily in vaccination rates increases transmission). Applying Bayesian deep learning and fine-grained epidemic simulations, we show a negative effect of homophily and a positive effect of highly vaccinated hubs on reducing case counts for both the synthetic network and the U.S. mobility network. Our framework enables us to evaluate the outcome of various hypothetical spatial vaccine distributions and propose a vaccination campaign strategy that targets a small number of regions with the largest gain in protective power, given the state of the COVID-19 as of January 2022. Our simulation shows that our strategy can prevent about 2.5 times more cases than a uniform strategy with an additional 1\% of the population vaccinated. Our study suggests that we must examine the interplay between vaccination patterns and mobility networks beyond the overall vaccination rate, and that accurate location-based targeting can be just as important as improving the overall vaccination rate.
Wide Refractive Index Detection Range Surface Plasmon Resonance Sensor Based On D-shaped Photonic Crystal Fiber
Authors: Pan Honggang , Pan Fei , Zhang Ailing , Cao Chuanbo , Xue Fengjun 
Published: February 2022

Abstract
We propose a surface plasmon resonance (SPR) refractive index (RI) sensor based on a novel D-shaped photonic crystal fiber. We used an open air hole coated with gold film to improve SPR effect. The effects of structural parameters on resonance spectrum were analyzed by finite element method (FEM). Three SPR peaks were obtained in the wavelength range of 800nm-1300nm. The simulation results show that the refractive index detection range of the sensor is 1.26-1.38. The maximum sensitivity is 5626.86 nm/RIU and the maximum resolution is 1.78×10-5 RIU at the refractive index of 1.38. The sensor uses photonic crystal fiber with the same air holes diameter. Compared with other D-shaped structures, our sensor can measure larger RI ranges of the analyte.
Leaching characteristics and pollution risk assessment of potentially harmful elements from coal gangue exposed to weathering at different time
Authors: Shi Longqing , Peng Jinfeng , Xu Dongjing , Tian Jinjin , Liu Tianhao , Jiang Binbin , Zhang Facai 
Published: February 2022

Abstract
This study explored the fresh coal gangue present in the goaf of the Hongqi Coal Mine and the coal gangue present on the surface of the mining area (weathered over a period of one year) to study the migration mechanism of pollutants when different types of coal gangue backfill goaf. Static immersion comparative experiments were conducted to determine the dissolution characteristics of Fe3+, Mn2+, SO42–, and other major pollutants present in the two types of coal gangue. The results revealed that under the same soaking conditions, weathered coal gangue released more polluting elements than fresh coal gangue. Moreover, the ion concentration in the soaking solution fluctuated significantly. Meanwhile, the Fe3+ concentration presents a “wave-like” trend, and the Mn2+ and SO42– concentrations fluctuated significantly during the early stages (1–7 d). The trend changed during the middle and late periods (after 7d). The Mn2+ content in the soaking solution of the fresh coal gangue decreased slowly, while the Mn2+ content in the weathered coal gangue increased steadily. The changes in the pH exhibited a “logarithmic trend”, and the pH of the fresh group was slightly higher than that of the weathered group. Based on the evaluation of the geo-accumulation index, combined with the pollution level evaluation standard, it was found that the levels of heavy metal elements produced by the weathered coal gangue are significantly higher than the levels produced by fresh coal gangue, which are more likely to pollute groundwater and damage the ecological environment.
Decision-making and Related Outcomes of Patients with Complex Care Needs in Primary Care Settings : A Systematic Literature Review with A Case-based Qualitative Synthesis
Authors: Bujold Mathieu , Pluye Pierre , Légaré France 
Published: February 2022

Abstract
BackgroundIn primary care, patients increasingly face difficult decisions related to complex care needs (multimorbidity, polypharmacy, mental health issues, social vulnerability and structural barriers). There is a need for pragmatic conceptual model to understand decisional needs among patients with complex care needs and outcomes related to decision. We aimed to identify types of decisional needs among patients with complex care needs, and decision-making configurations of conditions associated with decision outcomes. MethodsWe conducted a systematic mixed studies review. Two specialized librarians searched five bibliographic databases (Medline, Embase, PsycINFO, CINAHL and SSCI). A team of twenty crowd-reviewers selected empirical studies on: (1) patients with complex care needs; (2) decisional needs; (3) primary care. Two reviewers appraised the quality of included studies using the Mixed Methods Appraisal Tool. We conducted a 2-phase case-based qualitative synthesis framed by the Ottawa Decision Support Framework and Gregor’s explicative-predictive theory type. A decisional need case involved: (a) a decision (what), (b) concerning a patient with complex care needs with bio-psycho-social characteristics (who), (c) made independently or in partnership (how), (d) in a specific place and time (where/when), (e) with communication and coordination barriers or facilitators (why), and that (f) influenced actions taken, health or well-being, or decision quality (outcomes). ResultsWe included 47 studies. Data sufficiency qualitative criterion was reach. We identified 69 cases (2997 participants across 13 countries) grouped into five types of decisional needs: “prioritization” (n=26), “use of services” (n=22), “prescription” (n=12), “behavior change” (n=4) and “institutionalization” (n=5). Many decisions were made between clinical encounters in situations of social vulnerability. Patterns of conditions associated with decision outcomes revealed four decision-making configurations: “well-managed” (n=13), “asymmetric encounters” (n=21), “self-management by default” (n=8), and “chaotic” (n=27). Shared decision-making was associated with positive outcomes. Negative outcomes were associated with independent decision-making. ConclusionOur results could extend decision-making models in primary care settings and inform subsequent user-centered design of decision support tools for heterogenous patients with complex care needs populations.
Shared mobility may limit vehicle lifetimes – implications for the carbon footprint
Authors: Morfeldt Johannes , Johansson Daniel 
Published: February 2022

Abstract
Car sharing and ride sharing will likely increase the annual vehicle driving distance, which in turn may accelerate passenger car retirement. In this study, we develop a semi-empirical lifetime-driving intensity model. We integrate our model with a carbon footprint estimation model, which assesses future decarbonization of global, European, and Swedish energy systems. We calibrate the lifetime-driving intensity model using Swedish vehicle retirement statistics, which suggest that driving intensity strongly impacts vehicle lifetimes. Our combined model shows that use-phase emissions depend on driving intensity, while manufacturing emissions are distributed over the cumulative driving distance. Hence, the carbon footprint depends on both the calendar age and cumulative driving distance of the vehicle. The results of our study also show that higher driving intensities generally result in lower carbon footprints. However, empty travel by shared autonomous vehicles, i.e., the additional distance traveled to pick up passengers, may cause carbon footprints to increase.