bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photosensitizing properties and subcellular localisation of 3,4-dihydro-β-carbolines harmaline and harmalol
Authors: Denofrio M. Paula , Paredes Jose M. , Yañuk Juan G. , Giron Maria D. , Salto Rafael , Talavera Eva M. , Crovetto Luis , Cabrerizo Franco M. 
Published: November 2022

AbstractHarmaline (1) and harmalol (2) represent two3,4-dihydro-β-carboline (DHβCs) most frequently reported in a vast number of living systems. Fundamental aspects including the photosensitizing properties, cellular uptake, as well as the cyto- and phototoxicity of1and2were investigated herein. The molecular basis underlying the investigated processes are elucidated. Data reveal that both alkaloids show a distinctive pattern of extracellular DNA photodamage. Compound1induces a DNA photodamage profile dominated by oxidised purines and sites of base loss (AP sites), whereas2mostly induces single-strand breaks (SSBs) in addition to a small extent of purine oxidative damage. In both cases, DNA oxidative damage would occur through type I mechanism. In addition, a concerted hydrolytic attack is suggested as an extra mechanism accounting for the SSBs formation photoinduced by2. Subcellular internalisation, cyto- and phototoxicity of1and2and the corresponding full-aromatic derivatives harmine (3) and harmol (4) also showed quite distinctive patterns in a structure-dependent manner. These results are discussed in the framework of the potential biological, biomedical and/or pharmacological roles reported for these alkaloids.Graphical abstractThe subtle structural difference (i.e., the exchange of a methoxy group for a hydroxyl substituent at C(7)) between harmaline and harmalol, gives rise to distinctive photosensitizing and subcellular localisation patterns.
A novel route to estimate the photocatalytic activity of titanium dioxide via voltage measurements
Authors: Kurz Jochen , Erdinger Lothar 
Published: November 2022

AbstractTitanium dioxide is known as a photocatalyst, that may be activated by UV-A light and thus be able to lead to chemical reactions, to mineralize organic compounds, to inactivate biomolecules and to kill microorganisms, respectively. To estimate the capability of the photocatalytic activity a novel experimental setup using photovoltage measurements was studied. A distinct correlation between the photocatalytic activity of the titanium dioxide samples and the measurable photovoltages could be demonstrated. The experimental setups included the construction of different electrochemical cells based on TiO2 and using different liquid and gel electrolytes. The investigations were carried out on titanium dioxide layers as well as on TiO2 particle materials. The electrochemical measurement of the resulting voltage was optimised and the results were compared with conventionally used methods for the determination of the photocatalytic activity like the decolourization of methylene blue solutions. Additionally, the increase of carbon dioxide concentration in the gas phase was taken as a measure for total mineralization. Results indicate strong correlations between the different methods.
Graphical Abstract
Ensuring Privacy and Confidentiality in Social Work Through Intentional Omissions of Information in Client Information Systems: a Qualitative Study of Available and Non-available Data
Authors: Schneider Diana 
Published: November 2022

Abstract
There is intensive debate about the use of AI-based systems in social work, although the degree of digitalization is low in many jurisdictions. In this article, the findings of research about the process of case recording in client information systems for social work are presented. Between January and June 2020, 20 guideline-based interviews were conducted with experts working for funding agencies or service providers. A significant finding was that there are intentional omissions of information within digital client records, despite being relevant for further case processing. This finding and the reasons for omission are highly relevant to the current debate on AI, because it extends consideration beyond the ethics of design to include the ethics of usage.
Recent development of eco-friendly nanocomposite carbon paste electrode for voltammetric determination of Cd(II) in real samples
Authors: Rahim Asmaa M. Abdel , Mahmoud Esraa M. M. 
Published: November 2022

AbstractUsing eco-friendly, cheap, and available adsorbents is promising for the determination of metal ions. So, this study focuses on the modification of graphite reinforcement carbon paste electrode (GRCPE) with mango seed kernel (MSK) for voltammetric determination of Cd(II). Moreover, to increase the surface area of this adsorbent, it was prepared in nanosized that formed nanoparticles of mango seed kernel (MSK-NPs). The developed nanocomposite electrode of carbon paste electrode modified with nanoparticles of mango seed kernel (MSK-NPs@GRCPE) was characterized using Fourier transform infrared (FTIR) and Scanning electron microscopy (SEM). The effect of pH, buffer solution, and supporting electrolyte as experimental conditions were optimized through differential pulse adsorptive anodic stripping voltammetric method (DPAdASV). Britton-Robinson buffer pH = 3.9 at Eacc = – 1400 mV, tacc = 30 s, pulse width = 10 ms and sampling time = 8 ms were the optimum conditions for determination of Cd(II). The LOD and LOQ of MSK-NPs@GRCPE were calculated at 5.44 × 10–9 and 1.65 × 10–8 M, respectively. Compared with bare graphite reinforcement carbon paste electrode (BGRCPE), the nanocomposite MSK-NPs@GRCPE has a lower detection limit, indicating that the presence of MSK-NPs could greatly improve the response to Cd(II). The practical applicability of the electrode was verified by the determination of Cd(II) in chocolate and white rice samples. The results show high selectivity and sensitivity for Cd(II) in real samples.
Graphical abstract
Shortcut English: Pidgin Language, Racialization, and Symbolic Economies at a Chinese-Operated Mine in Zambia
Authors: Haruyama Justin Lee 
Published: November 2022

Abstract“Shortcut English” is a pidgin spoken between Zambians and Chinese migrants at a Chinese-operated mine in southern Zambia. Contrary to most historical contact languages, the symbolic valences of Shortcut English favor the Zambian laborers over the Chinese mine managers and owners. In the past, Zambians at Summers have categorized Chinese asbamukuwa/ “whites.” Haruyama analyzes how the racializing dynamics of the new pidgin Shortcut English increasingly result in Chinese being figured asmachainizi, a denigrated racial other whom Zambians see as unfit to run the mine, which contributes to sometimes violent resistance.
Data as Assets in Foreign Direct Investment: Is China's National Data Governance Compatible with its International Investment Agreements?
Authors: BIAN Cheng 
Published: November 2022

AbstractTo foreign investors, data, either collected and processed before or after market entry in the host state, can be regarded as a part of the investment and subject to the protection of the applicable international investment agreements (IIAs). China has been developing rigorous and stringent data governance such as data localization requirements and mandatory business-to-government data sharing, and has also concluded the world's second largest IIA regime that provides sweeping investment protection. There is a risk of incompatibility between China's national data policies and its IIA obligations. Foreign investors may challenge China's national laws and practices on data governance, for alleged breaches of investor's protection obligations in Chinese IIAs, or breaches of the data residency provisions in Chinese trade and investment agreements. As a result, potential exists for such claims to be brought against China in investor-state arbitration.
Modeling Viscosity of Volcanic Melts With Artificial Neural Networks
Authors: Langhammer D. , Di Genova D. , Steinle‐Neumann G. 
Published: November 2022

AbstractViscosity is of great importance in governing the dynamics of volcanoes, including their eruptive style. The viscosity of a volcanic melt is dominated by temperature and chemical composition, both oxides and water content. The changes in melt structure resulting from the interactions between the various chemical components are complex, and the construction of a physical viscosity model that depends on composition has not yet been achieved. We therefore train an artificial neural network (ANN) on a large database of measured compositions, including water, and viscosities that spans virtually the entire chemical space of terrestrial magmas, as well as some technical and extra‐terrestrial silicate melts. The ANN uses composition, temperature, a structural parameter reflecting melt polymerization and the alkaline ratio as input parameters. It successfully reproduces and predicts measurements in the database with significantly higher accuracy than previous global models for volcanic melt viscosities. Viscosity measurements are restricted to low and high viscosity ranges, which exclude typical eruptive temperatures. Without training data at such conditions, the ANN cannot reliably predict viscosities for this important temperature range. To overcome this limitation, we use the ANN to create synthetic viscosity data in the high and low viscosity range and fit these points using a physically motivated, temperature‐dependent viscosity model. Our study introduces a synthetic data approach for the creation of a physically motivated model predicting volcanic melt viscosities based on ANNs.
Energetic Magnetospheric Particle Fluxes Onto Callisto's Atmosphere
Authors: Liuzzo Lucas , Poppe Andrew R. , Addison Peter , Simon Sven , Nénon Quentin , Paranicas Christopher 
Published: November 2022

AbstractThis study investigates how Callisto's perturbed electromagnetic environment—generated by the moon's interaction with the low‐energy Jovian magnetospheric plasma—affects the dynamics of high‐energy ions and electrons. We constrain how these perturbed fields influence the energetic particle fluxes deposited onto the top of Callisto's atmosphere between energies of 4.5 keV ≤ E ≤ 11.8 MeV. We use a hybrid simulation to model the variability in Callisto's perturbed electromagnetic environment over a synodic period by considering three representative scenarios of the moon's plasma interaction, corresponding to various distances of the moon to the Jovian magnetospheric current sheet. The local field perturbations are maximized near the center of the sheet (forming, e.g., signatures of field‐line pileup, draping, and Alfvén wings) whereas far from the sheet, a mere superposition of the moon's induced dipole with the background field largely explains the perturbations. We then apply a test‐particle approach to investigate the dynamics of energetic electrons and ions (protons, oxygen, and sulfur) while exposed to these fields. Since electron gyroradii are smaller than Callisto, the field perturbations generate small‐scale non‐uniformities in their flux patterns onto the moon, while the ion flux patterns are more homogeneous. Energetic electrons dominate the number flux onto the atmosphere, whereas ions dominate the energy flux. Over a synodic period, the flux patterns onto Callisto's exobase closely resemble those when the moon is near the current sheet center, since the differential energetic particle fluxes in the ambient plasma decrease by an order of magnitude when the moon travels far outside of the sheet.
Frictional Behavior Downdip Along the Subduction Megathrust: Insights From Laboratory Experiments on Exhumed Samples at In Situ Conditions
Authors: den Hartog S. A. M. , Marone C. , Saffer D. M. 
Published: November 2022

AbstractSubduction megathrusts exhibit a spectrum of slip modes, including catastrophic earthquakes. Although the mechanical and frictional properties of materials sampled from subduction zones have been studied extensively, few datasets have been collected for compositions and at pressure and temperature conditions representative of those in situ. The Nankai subduction zone in southwest Japan is a well‐studied margin, and abundant data provide an opportunity to advance our understanding of fault and earthquake physics. Here, we use samples exhumed in the Shimanto and Sanbagawa Belts on Shikoku Island of southwest Japan that represent analogs for materials along the present‐day megathrust at depths of ∼5–>25 km, and we shear these at their peak in situ pressure‐temperature (P‐T) conditions. Effective normal stresses range from 28 to 192 MPa, and temperatures from 105°C to 470°C. We used pore fluid pressures of 45–240 MPa, corresponding to fluid overpressure ratios λ of 0.65 and 0.90. Slip velocities of 0.1–100 μm/s were used, in order to focus on the nucleation of instability and earthquakes. We found predominantly velocity‐strengthening (inherently stable) behavior under all conditions for λ = 0.65. For λ = 0.90, velocity‐weakening behavior was observed at 350°C, with velocity‐strengthening behavior at lower and higher temperatures. The rate/state frictional stability parameter (a‐b) increases with slip velocity at temperatures up to ∼200°C and remains constant or decreases with slip velocity at higher temperatures. Overall, our results demonstrate the potentially important roles of both temperature and slip velocity in controlling the distribution of stress and frictional rheology along subduction thrusts.
Temperatures and Timescales of Crystallization in the “Mush Zone” Beneath Fast‐Spreading Ocean Ridges
Authors: VanTongeren J. A. , Kelemen P. B. , Grove T. L. 
Published: November 2022

AbstractQuantifying the timescales of magma solidification and eruption beneath mid‐ocean ridges is critical to understanding how melts are emplaced and crystallized, and how long these magmas and their crystals remain in a semi‐molten “mush‐like” state. Here, we present a new method to quantify the crystallization and solidification temperatures of individual gabbros in the lower crust of the Wadi Tayin massif (Samail ophiolite). Cotectic crystallization temperatures of olivine + plagioclase + clinopyroxene are constrained by our clinopyroxene Mg# thermometer, and supported by clinopyroxene‐olivine Fe‐Mg equilibration temperatures. We find that lower crustal gabbros reach the cotectic at approximately 1,160 ± 16°C, and are fully solidified between 781 and 1011°C, depending on cooling rate. Our results show that lower crustal gabbros spend, on average, 7,500–11,500 years in a partially molten state with no systematic change in duration with depth in the crust. Samples with very fast cooling rates result in solidification only a few tens of meters off‐axis from their emplacement location and likely indicate solidification near the distal edge of the on‐axis melt lens or in off‐axis melt lenses. Incorporating a uniform 1 km wide emplacement region directly on‐axis, as inferred geophysically, and a half‐spreading rate of 55 mm/yr, our results suggest that the Mush Zone at fast‐spreading ridges remains partially molten for 0–3 km away from the ridge axis, but up to 4–7 km considering all possible sources of uncertainty. Both geophysical and geochemical estimates of the Mush Zone are inconsistent with conductive cooling of the lower oceanic crust.
A Proper Use of the Adjacent Land‐Based Observatory Magnetic Field Data to Account for the Geomagnetic Disturbances During Offshore Directional Drilling
Authors: Kruglyakov Mikhail , Kuvshinov Alexey , Nair Manoj 
Published: November 2022

AbstractDirectional drilling in the oil fields relies particularly on the “on‐fly” measurements of the natural magnetic field (measurements while drilling; MWD); the MWD are eventually used to construct the well path. These measurements are the superposition of the signals from the internal, core and crustal, and external, ionospheric and magnetospheric sources and the noise from magnetic elements in the borehole assembly. The internal signals are mostly constant in time and accounted for through the Earth's internal field models. The signals of external origin give rise to diurnal and irregular spatio‐temporal magnetic field variations observable in the MWD. One of the common ways to mitigate the effects of these variations in the MWD is to correct readings for the data from an adjacent land‐based magnetic observatory/site. This method assumes that the land‐based signals are similar to those at the seabed drilling site. In this paper, we show that the sea level and seabed horizontal magnetic fields differ significantly, reaching up to 30% of sea level values in many oceanic regions. We made this inference from the global forward modeling of the magnetic field using realistic models of conducting Earth and time‐varying sources. To perform such modeling, we elaborated a numerical approach to efficiently calculate the spatio‐temporal evolution of the magnetic field. Finally, we propose and validate a formalism allowing researchers to obtain trustworthy seabed signals using measurements at the adjacent land‐based site and exploiting the modeling results, thus without needing additional measurements at the seabed site.
The Origin of the Paleo‐Kuril Arc, NE Japan: Sediment Provenance Change and Its Implications for Plate Configuration in the NW Pacific Region Since the Late Cretaceous
Authors: Harisma H. , Naruse H. , Asanuma H. , Hirata T. 
Published: November 2022

AbstractThe Nemuro Belt is a tectonic belt in the Paleo‐Kuril Arc system, the NW Pacific region. The Paleo‐Kuril Arc has been interpreted as an intraoceanic arc system between the Izanagi and Pacific Plates during the Late Cretaceous, suggesting that the boundary between these plates was a trench. However, this study shows it was a volcanic arc that developed atop a continental margin. To determine the nature of this arc during the Late Cretaceous, U‐Pb ages of detrital zircons from the Nemuro and Urahoro Groups in the Paleo‐Kuril Arc were analyzed. Our results identify two distinct types of detrital zircon U‐Pb age distributions. The first (Type 1) is characterized by multimodal age distributions with peaks ranging from ca. 1.8 Ga to 78 Ma. The other (Type 2) exhibits a unimodal age distribution with a peak at 60‐52 Ma. These different age distributions indicate a provenance transition occurred between the Late Cretaceous and Paleogene. Precambrian zircons in Type 1 sandstones indicate that the Paleo‐Kuril Arc was part of a continental plate, presumably the Okhotsk Block, in NE Asia during the Late Cretaceous. In contrast, Type 2 sandstones were supplied only from the magmatic arc region that the Izanagi‐Pacific Ridge subduction could have activated. This provenance transition suggests the initially continental arc became separated from its continental source at the beginning of the Paleogene.
A Deeper Look Into the 2021 Tyrnavos Earthquake Sequence (TES) Reveals Coseismic Breaching of an Unrecognized Large‐Scale Fault Relay Zone in Continental Greece
Authors: Mouslopoulou Vasiliki , Sudhaus Henriette , Konstantinou Kostas I. , Begg John , Saltogianni Vasso , Männel Benjamin , Andinisari Ratri , Oncken Onno 
Published: November 2022

AbstractLarge magnitude (Mw ∼ ≥6) earthquakes in extensional settings are often associated with simultaneous rupture of multiple normal faults as a result of static and/or dynamic stress transfer. Here, we report details of the coseismic breaching of a previously unrecognized large‐scale fault relay zone in central Greece, through three successive normal fault earthquakes of moderate magnitude (Mw 5.7–6.3) that occurred over a period of ∼10 days in March 2021. Specifically, joint analysis of InSAR, GNSS and seismological data, coupled with detailed field and digital fault mapping, reveals that the Tyrnavos Earthquake Sequence (TES) was accommodated at the northern end of a ∼100 km wide transfer structure, by faults largely unbroken during the Holocene. By contrast, the southern section of this relay zone appears to have accrued significant slip during Holocene. InSAR‐derived displacements agree with the loci of eight subtle, previously undetected, faults that accommodated coseismic and/or syn‐seismic normal fault slip during the TES. Kinematic modeling coupled with fault mapping suggests that all involved faults are interconnected at depth, with their conjugate fault‐intersections acting largely as barriers to coseismic rupture propagation. We also find that the TES mainshocks were characterized by unusually high (>6 MPa) stress‐drop values that scale inversely with rupture length and earthquake magnitude. These findings, collectively suggest that the TES propagated north‐westward to rupture increasingly stronger asperities at fault intersections, transferring slip between the tips of a well‐established, but previously unrecognized, relay structure. Fault relay zones may be prone to high stress‐drop earthquakes and associated elevated seismic hazard.
A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis
Authors: Ma Qizhi , He Xia , Zhang Benxia , Guo Fuchun , Ou Xuejin , Yang Qiyu , Shu Pei , Chen Yue , Li Kai , Gao Ge , Zhu Yajuan , Qin Diyuan , Tang Jie , Li Xiaoyu , Jing Meng , Zhao Jian , Mo Zeming , Liu Ning , Zeng Yao , Zhou Kexun , Feng Mingyang , Liao Weiting , Lei Wanting , Li Qiu , Li Dan , Wang Yongsheng 
Published: November 2022

AbstractPleural and peritoneal metastasis accompanied by malignant pleural effusion (MPE) or malignant ascites (MA) is frequent in patients with advanced solid tumors that originate from the lung, breast, gastrointestinal tract and ovary. Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination in serous cavities. However, malignant effusions constitute an immune-suppressive environment that potentially induces CAR-T cell dysfunction. Here, we demonstrated that the anti-tumor cytotoxicity of conventional 2nd-generation CAR-T cells was significantly inhibited by both the cellular and non-cellular components of MPE/MA, which was primarily attributed to impaired CAR-T cell proliferation and cytokine production in MPE/MA environment. Interestingly, we found that PD-L1 was widely expressed on freshly-isolated MPE/MA cells. Based on this feature, a novel PD-L1-targeting chimeric switch receptor (PD-L1.BB CSR) was designed, which can bind to PD-L1, switching the inhibitory signal into an additional 4-1BB signal. When co-expressed with a 2nd-generation CAR, PD-L1.BB CSR-modified CAR-T cells displayed superior fitness and enhanced functions in both culture medium and MPE/MA environment, causing rapid and durable eradication of pleural and peritoneal metastatic tumors in xenograft models. Further investigations revealed elevated expressions of T-cell activation, proliferation, and cytotoxicity-related genes, and we confirmed that PD-L1 scFv and 4-1BB intracellular domain, the two important components of PD-L1.BB CSR, were both necessary for the functional improvements of CAR-T cells. Overall, our study shed light on the clinical application of PD-L1.BB CSR-modified dual-targeting CAR-T cells. Based on this study, a phase I clinical trial was initiated in patients with pleural or peritoneal metastasis (NCT04684459).