bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Susceptibility of Treatment-Resistant Oesophageal Tumours to Natural Killer Cell-Mediated Responses.
Authors: Mylod Eimear , Mckenna Ellen , Davern Maria , Barr Martin P , Donlon Noel E , Bibby Becky AS , Bhardwaj Anshul , Reynolds John V , Lysaght Joanne , Maher Stephen G. , Conroy Melissa J. 
Published: February 2022

Abstract
Introduction: The majority of oesophageal adenocarcinoma (OAC) patients do not respond to multimodal treatment regimens and face dismal survival rates. Natural killer (NK) cells are crucial anti-tumour immune cells, and this study investigated the susceptibility of treatment-resistant OAC cells to these potent tumour killers.Methods: Natural killer receptor (NKR) ligand expression by OE33CisP (cisplatin-sensitive) and OE33CisR (cisplatin-resistant) cells was investigated. The immunomodulatory effects of OE33CisP and OE33CisR cells on NK cell phenotype and function were assessed. Finally, the impact of chemotherapy regimens on NKR ligand shedding was examined.Results: Our data revealed significantly less surface expression of activating ligands B7-H6, MICA/B, ULBP-3 and activating/inhibitory ligands PVRL-1 and PVRL-4 by OE33CisR cells, compared to OE33CisP cells. Co-culture with OE33CisR cells reduced the frequencies of Nkp30+ and NKp46+ NK cells and increased frequencies of TIGIT+, FasL+ and TRAIL+ NK cells. Frequencies of IFN-γ-producing NK cells increased while frequencies of TIM-3+ NK cells decreased after culture with OE33CisP and OE33CisR cells. Frequencies of circulating NKP30+ NK cells were significantly lower in OAC patients with the poorest treatment response and in patients who received FLOT chemotherapy. B7-H6 shedding by OAC tumour cells was induced by FLOT.Conclusion: OE33CisR cells express less activating NKR ligands than OE33CisP cells and have differential effects on NKR expression by NK cells. However, neither cell line significantly dampened NK cell cytokine production, death receptor expression or degranulation. Finally, our data indicate that FLOT chemotherapy and obesity may promote B7-H6 shedding and immune evasion with detrimental consequences in OAC patients.
Тревога и неопределенность в межкультурном взаимодействии: экспериментальное исследование
Authors: Хухлаев Олег Е. , Браткина Мария А. 
Published: February 2022

Введение. В статье представлены результаты экспериментального исследования вклада тревоги и неопределенности в межкультурное взаимодействие, рассмотренного в контексте теории управления беспокойством/неопределенностью У. Гудиканста. Несмотря на наличие корреляционных исследований, подтверждающих базовые положения теории, экспериментально изучены только предпосылки желания взаимодействовать с представителями людьми иной культуры, которое является одной из характеристик эффективного межкультурного взаимодействия. Более представленным в теории управления беспокойством/неопределенностью критерием эффективности межкультурного общения является воспринимаемая эффективность межкультурного общения, ранее экспериментально не изученная. Эксперимент был нацелен как на проверку гипотезы о существовании прямого эффекта ситуаций неопределенности и тревоги на воспринимаемую эффективность межкультурного взаимодействия, так и на изучение опосредования данного влияния воспринимаемой предсказуемостью межкультурного общения и воспринимаемой межгрупповой тревогой. Методы. В исследовании использован экспериментальный дизайн 2 (манипуляция неопределенностью) × 2 (манипуляция тревогой). В качестве зависимых переменных выступали воспринимаемая предсказуемость межкультурного общения, межгрупповая тревога и воспринимаемая эффективность межкультурного взаимодействия в предполагаемом общении с партнером из Колумбии. Всего в эксперименте приняло участие 92 человека, возраст от 18 до 44 лет, 78 % из которых составляли женщины. Эксперимент проходил онлайн, на платформе для видеоконференций Zoom. Результаты. Проверка гипотез была осуществлена с помощью медиационного анализа, основанного на регрессиях. Экспериментально продемонстрированы непрямые эффекты ситуации неопределенности и тревоги на воспринимаемую эффективность межкультурной коммуникации. При этом данная связь опосредована воспринимаемой предсказуемостью и воспринимаемой межгрупповой тревогой. Обсуждение результатов. Результаты исследования соответствуют предположениям теории управления беспокойством/неопределенностью У. Гудиканста и выступают ее первым экспериментальным подтверждением. При этом показано, что тревога и неопределенность являются разными путями обеспечения эффективности межкультурного общения.
Arginine Vasopressin, Synaptic Plasticity, and Brain Networks
Authors: Winklewski Pawel J. , Marcinkowska Anna B. , Biancardi Vinicia C. 
Published: February 2022

Abstract:
The arginine vasopressin (AVP) neurohypophysial hormone is synthesized within specific central nervous system sites and axonally transported to multiple areas, acting as a neurotransmitter/neuromodulator. In this context, AVP acts primarily through vasopressin receptors A and B and is involved in regulating complex social cognition and behaviors and basic autonomic function. Many earlier studies have shown that AVP as a neuromodulator affects synaptic plasticity. This review updates our current understanding of the underlying molecular mechanisms by which AVP affects synaptic plasticity. Moreover, we discuss AVP modulatory effects on event-related potentials and blood oxygen level-dependent responses in specific brain structures and AVP effects on the network level oscillatory activity. We aimed at providing an overview of the AVP effects on the brain from synaptic to the network level.
The Role of Bupropion in the Treatment of Women with Sexual Desire
Disorder: A Systematic Review and Meta-Analysis
Authors: Sidi Hatta , Razali Nur Atikah , Choy Chia Lip , Roos Nur Aishah Che , Baharudin Azlin , Das Srijit 
Published: February 2022

Abstract:
Although few clinical trials examined the efficacy of bupropion to treat sexual dysfunction
among female patients, a comprehensive and objective synthesis of the best available evidence
is still lacking. To date, to the best of our knowledge, there are no published systematic reviews or
meta-analyses specifically focusing on the role of bupropion in the treatment of female sexual dysfunction.
The main objective of the present study was to evaluate the efficacy of bupropion in the
treatment of female sexual dysfunction, and we hypothesized that bupropion is efficient in treating
female patients with sexual dysfunction. This review was conducted following the Preferred Reporting
Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search
for published literature was performed using Ovid, Medline, Scopus, Cochrane Library, Science Direct,
and PubMed databases. In our study, we found that bupropion was almost three-fold more favorable
in improving problems with sexual desire (pool estimate 2.845, 95% CI: 0.215 to 5.475, I2=
95.6%, p=0.034). A meta-regression was performed to explore heterogeneity and we found that only
the dosage of bupropion was statistically significant in explaining the variance, i.e., the lower the
dosage (150 mg vs. 300 mg), the better the improvement in the sexual desire of women with hypoactive
sexual desire disorder (HSDD). Based on the results of this systematic review and metaanalysis,
there is a potential role of bupropion as an effective treatment for women with HSDD.
An Update on Nondopaminergic Treatments for Motor and Non-motor
Symptoms of Parkinson’s Disease
Authors: Jing Xiao-Zhong , Yuan Xiang-Zhen , Luo Xingguang , Zhang Shu-Yun , Wang Xiao-Ping 
Published: February 2022

Abstract:
Nondopaminergic neurotransmitters such as adenosine, norepinephrine, serotonin, glutamate,
and acetylcholine are all involved in Parkinson's disease (PD) and promote its symptoms.
Therefore, nondopaminergic receptors are key targets for developing novel preparations for the
management of motor and non-motor symptoms in PD, without the potential adverse events of dopamine
replacement therapy. We reviewed English-written articles and ongoing clinical trials of
nondopaminergic treatments for PD patients till 2014 to summarize the recent findings on nondopaminergic
preparations for the treatment of PD patients. The most promising research area of nondopaminergic
targets is to reduce motor complications caused by traditional dopamine replacement
therapy, including motor fluctuations and levodopa-induced dyskinesia. Istradefylline, Safinamide,
and Zonisamide were licensed for the management of motor fluctuations in PD patients, while novel
serotonergic and glutamatergic agents to improve motor fluctuations are still under research. Sustained-
release agents of Amantadine were approved for treating levodopa induced dyskinesia (LID),
and serotonin 5HT1B receptor agonist also showed clinical benefits to LID. Nondopaminergic targets
were also being explored for the treatment of non-motor symptoms of PD. Pimavanserin was approved
globally for the management of hallucinations and delusions related to PD psychosis.
Istradefylline revealed beneficial effect on daytime sleepiness, apathy, depression, and lower urinary
tract symptoms in PD subjects. Droxidopa may benefit orthostatic hypotension in PD patients.
Safinamide and Zonisamide also showed clinical efficacy on certain non-motor symptoms of PD patients.
Nondopaminergic drugs are not expected to replace dopaminergic strategies, but further development
of these drugs may lead to new approaches with positive clinical implications.
Novel Molecular Networks and Regulatory MicroRNAs in Type 2 Diabetes Mellitus: Multiomics Integration and Interactomics Study
Authors: Khokhar Manoj , Roy Dipayan , Tomo Sojit , Gadwal Ashita , Sharma Praveen , Purohit Purvi 
Published: February 2022

Background
Type 2 diabetes mellitus (T2DM) is a metabolic disorder with severe comorbidities. A multiomics approach can facilitate the identification of novel therapeutic targets and biomarkers with proper validation of potential microRNA (miRNA) interactions.

Objective
The aim of this study was to identify significant differentially expressed common target genes in various tissues and their regulating miRNAs from publicly available Gene Expression Omnibus (GEO) data sets of patients with T2DM using in silico analysis.

Methods
Using differentially expressed genes (DEGs) identified from 5 publicly available T2DM data sets, we performed functional enrichment, coexpression, and network analyses to identify pathways, protein-protein interactions, and miRNA-mRNA interactions involved in T2DM.

Results
We extracted 2852, 8631, 5501, 3662, and 3753 DEGs from the expression profiles of GEO data sets GSE38642, GSE25724, GSE20966, GSE26887, and GSE23343, respectively. DEG analysis showed that 16 common genes were enriched in insulin secretion, endocrine resistance, and other T2DM-related pathways. Four DEGs, MAML3, EEF1D, NRG1, and CDK5RAP2, were important in the cluster network regulated by commonly targeted miRNAs (hsa-let-7b-5p, hsa-mir-155-5p, hsa-mir-124-3p, hsa-mir-1-3p), which are involved in the advanced glycation end products (AGE)-receptor for advanced glycation end products (RAGE) signaling pathway, culminating in diabetic complications and endocrine resistance.

Conclusions
This study identified tissue-specific DEGs in T2DM, especially pertaining to the heart, liver, and pancreas. We identified a total of 16 common DEGs and the top four common targeting miRNAs (hsa-let-7b-5p, hsa-miR-124-3p, hsa-miR-1-3p, and has-miR-155-5p). The miRNAs identified are involved in regulating various pathways, including the phosphatidylinositol-3-kinase-protein kinase B, endocrine resistance, and AGE-RAGE signaling pathways.
The Role of Standards in Accelerating the Uptake of Artificial Intelligence in Dermatology
Authors: Caffery Liam J 
Published: February 2022

Background
The use of artificial intelligence (AI) for dermatology is showing great promise in research contexts. However, the clinical use of AI in dermatology is still limited. The uptake of medical imaging standards for dermatology imaging is also limited. Standards adoption is more widespread in other imaging specialties (eg, radiology) as is the clinical use of AI. Digital Image Communication in Medicine (DICOM) is the standard for medical imaging. DICOM standardizes image formats and associated metadata. Further, DICOM facilitates interoperability between actors in the digital health ecosystem.

Objective
This study aimed to identify how medical imaging standards, in particular DICOM, can support the clinical use of AI.

Methods
Design Science Research Methodology was used to determine the role of DICOM in AI-based medical imaging workflows. Scenarios were identified and synthesized using expert consensus.

Results
The key benefits of using DICOM to improve the clinical use of AI were the potential to encode artefacts derived from the AI process as DICOM objects and store them alongside the original images. Such objects include downsized or down-sampled images, segmentation objects, or visual explainability maps (eg, class activation maps). DICOM can facilitate interoperability between actors in the medical imaging workflow pipeline and permits the inclusion of AI evidence creators in this pipeline. Owing to standardized image formats and metadata, DICOM can be beneficial for the curation of multi-institutional data sets. The key challenge of using DICOM is limited uptake in some specialties including dermatology.

Conclusions
DICOM offers potential to accelerate the clinical adoption of AI in dermatology by addressing several technological issues. More widespread uptake of DICOM in dermatology imaging is required to achieve this potential.

Conflicts of Interest
None declared.
Characterisation of the inhibitory GABA/glycine projections of rostral ventromedial medulla neurons to the superficial dorsal horn of the spinal cord
Authors: Otsu Yo , Aubrey Karin 
Published: February 2022

Descending projections from neurons in the rostral ventromedial medulla
(RVM) make synapses within the superficial dorsal horn (SDH) of the
spinal cord that are involved in the modulation of acute nociception and
the development of chronic pain and itch. This projection is believed to
be primarily inhibitory but the relative contribution of GABA and
glycine transmission is unknown and there is limited knowledge about the
spinal targets of RVM-SDH projections.
We address this using ex vivo optogenetic stimulation of RVM
descending fibres in conjunction with whole-cell patch-clamp recordings
from SDH neurons in spinal cord slices. We demonstrate that SDH target
neurons have diverse morphological and electrical properties and that
RVM inputs onto these neurons are mediated by two inhibitory
neurotransmitters, GABA and glycine. Interestingly, one type of SDH
target neuron received glycine dominant inputs.
These findings confirm that descending RVM synaptic inputs to spinal
pain pathway neurons are largely inhibitory show that they involve not
only GABAergic but also glycinergic systems. The present study records
descending RVM inputs to SDH in isolation and provides mechanistic
information about the neurotransmitter systems this input uses to
control spinal pain/itch pathways.
Persiapan untuk Bekerja
Authors: Syukur Yarmis 
Published: February 2022

This paper is explain about preparation enter job/activity world. This preparation is needed because working to represent projection ability of someone to work which have selected of having completed education at certain education ladder. At others to the number of problems that happened and experienced of by after someone get work. Work also represent one of the life duty as healthy life caracter besides spiritualitas.
PELAKSANAAN PEMBELAJARAN SISWA BERKEBUTUHAN KHUSUS DI SMK NEGERI 4 PADANG
Authors: Ardisal Ardisal , Damri Damri 
Published: February 2022

Penelitian ini berawal dari penyelenggaraan proses pembelajaran siswa ABKh Tunanetra di SMKN Kota Padang. Penelitian ini bertujuan mendeskripsikan keadaan umum pembelajarannya meliputi penggunaan strategi pembelajaran, penggunaan metoda ,penyampaian materi pelajaran dan pengelolaan kelas Penelitian ini ditetapkan dengan teknik sampel bola salju yang terdiri siswa, guru, kepala sekolah, orang tua murid, pengawas sekolah, dinas pendidikan dan masyarakat. Informan tetap berjumlah 24 orang. Hasil Temuan, ada empat Tema Sentral keberhasilan penyelenggaraan pembelajaran di SMK.4 inklusi kota Padang. 1. Pelaksanaan program pendidikan inklusi di SMKN 4 Padang , sangat didukung oleh persepsi positif dari kepala sekolah, guru,GPK, orang tua, masyarakat dan dinas pendidikan. 2 strategi pembelajaran dan penggunaan metoda masih menggunakan pedoman regulasi umum, termasuk pengelolaan kelas sangat memerlukan perbaikan dan pembenahan. 3. Seluruh personil sekolah menjadi actor penting yang siap melayani semua anak, tanpa perbedaan dan bertanggung jawab atas kelancaran proses pelaksanaan pembelajaran sehingga kondisi diatas dapat menjadi kunci kemajuan sekolah inklusi. Kerjasama antar personal, baik kedalam maupun keluar sehingga pengembangan sekolah inklusi tidak banyak mengalami kendala yang berarti. meskipun masih memerlukan perbaikan pembenahan dan pengembangan. 4. Meskipun pelaksanaan pembelajaran SMK inklusi berjalan dengan baik, namun berbagai perbaikan seperti yang dituangkan dalam tema sentral diatas harus dan terus diperbaiki dan dikembangkan sebagaimana mestinya
PENERAPAN MODEL PEMBELAJARAN KONTEKSTUAL LEARNING (CTL) BERBASIS CENTRA DI TAMAN KANAK-KANAK
Authors: Eliza Delfi 
Published: February 2022

Learning Centra adalah pusat aktifitas pembelajaran yang dapat meningkatkan aspek perkembangan physik, sosial, emosional, dan intelektual. Strategi pembelajaran kontekstual learning (CTL) merupakan strategi pembelajaran yang dapat mengakomodasi kebutuhan dan perkembangan anak. Strategi pembelajaran kontekstual apabila diterapkan di Taman Kanak –kanak akan memberikan dampak tidak hanya dalam perkembangan kognitif yang lebih bermakna akan tetapi memberikan dampak penggiring seperti aktifitas fisik maupun mental anak. Penerapan model strategi CTL akan lebih baik bila diterapkan di pendekatan centra.
IMPLEMENTASI PERMAINAN TRADISIONAL INDONESIA DI TAMAN KANAK-KANAK KOTA PADANG
Authors: Nurhafizah Nurhafizah , Kosnin Azlina Mohd. 
Published: February 2022

Penelitian ini bertujuan untuk mendeskripsikan bagaimana pelaksanaan atau pengimplementasian permainan tradisional Indonesia di Taman Kanak-kanak kota Padang. Penelitian ini dilaksanakan selama 3 bulan dari bulan September sampai bulan November tahun 2012. Jenis penelitian yang digunakan adalah deskriptif dengan pendekatan kualitatif. Informan penelitian ini adalah guru dan siswa Taman Kanak-kanak kelompok B1. Teknik pengumpulan data adalah observasi, wawancara dan dokumentasi kemudian data analisis dengan menggunakan teknik analisa data Miles dan Huberman dengan cara reduksi data, penyajian data dan penarikan kesimpulan dari data yang diperoleh selama penelitian. Berdasarkan hasil penelitian maka dapat disimpulkan bahwa : (1) Dari perencanaan yang dibuat guru terlihat bahwa Permainan Tradisional Indonesia tidak menjadi bagian dari perencanaan pembelajaran secara spesifik. (2) Dari Pelaksanaan konsep bermain sambil belajar dan belajar seraya bermain di Taman Kanak-kanak tidak dijalankan sepenuhnya, terkesan hanya sebatas wacana saja, apa lagi pelaksanaan permainan tradisional Indonesia sendiri, kalaupun ada hanya sekali-sekali atau insidentil saja dan tidak terkonsep dengan baik.
PENINGKATAN KEMAMPUAN KOMUNIKASI PADA ANAK AUTISTIK MENGGUNAKAN DUKUNGAN VISUAL
Authors: Rahmahtrisilvia Rahmahtrisilvia 
Published: February 2022

Artikel ini membahas tentang peningkatan kemampuan komunikasi anak autistic melalui dukungan visual. Pembahasan ini muncul berdasarkan kondisi keterbatasan anak autistic dalam kemampuan komunikasi serta keterbatasan guru disekolah dalam pengembangan pembelajaran komunikasi. Komunikasi memegang peranan dalam kehidupan manusia agar dapat berinteraksi dengan orang lain. Salah satu pendekatan yang dapat digunakan dalam meningkatkan kemampuan anak autistic adalah dengan dukungan visual. Untuk meningkatkan komunikasi anak autistic perlu dikaji konsep dasar tentang komunikasi, aspek-aspek komunikasi, permasalahan komunikasi pada anak autistic, tahapan komunikasi pada anak autistic permasahan komunikasi. Kajian tentang dukungan visual dibahas dalam beberapa sub pembahasan yaitu pentingnya visual support bagi anak autistic, manfaat visual support, jenis-jenis visual support, dan cara menggunakan visual support.
KEPEMIMPINAN GURU DALAM PELAKSANAAN TUGASNYA DI KELAS
Authors: Ermita Ermita 
Published: February 2022

Abstract This paper to aim at desription about teacher’s leadership in accomplishment their task in class which analyse from education function and instructional function. Teacher’s leadership in educate can be performed by ways (a) give motivation to studens; teachers have to motivate studens in their’s behavior change process to better and better behavior. (b) To Guide studens; Teachers have to guide studens which behave are’t reconcile with norms. (c) To direction ; Teachers must be controll and direct studen’s activities, so that studens will not behave that to collide with norms. Teacher’s leadership in intructional can be performed by (a) give motivation to studens; teachers have to motivate studens in instructional process by technics select and use variation instructinal methods. (b) To Guide studens; Teacher must to guide student increase their achievement by technics direct training and assistance in exercises , (c) To direction; Teachers must be can to direct students in instructional process clearly, so that easy to be understood.
PENGEMBANGAN COMPUTER BASED TESTING (CBT) DALAM MATA KULIAH KEAHLIAN DAN KEILMUAN PADA PROGRAM STUDI TEKNOLOGI PENDIDIKAN
Authors: Eldarni Eldarni , Novrianti Novrianti 
Published: February 2022

Abstract Permasalahan evaluasi akhir perkuliahan selama ini pada program studi Teknologi Pendidikan adalah belum adanya bank soal yang terdokumentasikan secara terstruktur. Sehingga memberikan persoalan pelaksanaan ujian yang tertunda apabila dosen yang membina tidak dapat melaksanakan ujian. Disatu sisi hampir sebagaian besar soal yang diberikan berupa essay yang belum melalu proses analisis kelayakan. Sejalan dengan visi dan misi program studi Teknologi Pendidikan sebagai perekayasa pembelajaran, maka semestinya dengan ketersediaaan labor komputer yang lengkap memiliki satu program evaluasi yang menggunakan komputer atau CBT. Penelitian ini bertujuan untuk menghasilkan produk pelaksanaan evaluasi berbantuan komputer atau biasa dikenal dengan Computer Based Testing (CBT) yang sesuai dengan kriteria kelayakan media dan materi pada mata kuliah MKK program studi Teknologi Pendidikan melalui validasi beberapa ahli dan uji coba produk. Model penelitian pengembangan ini adalah model prosedural. Instrumen yang digunakan dalam penelitian ini adalah dokumentasi, format penilaian dengan kriteria yang meliputi aspek isi materi berupa Tes Pilihan Ganda dan aspek media, kemudian angket yang digunakan dalam pelaksanaan uji coba untuk melihat kemudahan bagi subjek coba menggunakan produk CBT. Hasil analisis menunjukkan bahwa produk CBT berada pada kategori Sangat Baik (89%), memiliki jumlah rerata skor sebesar 4,4 (skor maksimum 5). Untuk aspek isi termasuk dalam kategori Sangat Baik (96%) jumlah rerata skor sebesar 4,8 (skor maksimum 5). dan dari aspek media termasuk dalam kategori Sangat Baik (83%) jumlah rerata skor sebesar 4,1 (skor maksimum 5). Selanjutnya, hasil analisis berdasarkan uji coba produk CBT berada pada kategori Sangat Baik (94%) dengan rerata 4,7. Hasil tersebut menunjukkan bahwa produk CBT ini layak digunakan sebagai media alternatif untuk memecahkan permasalahan yang terjadi pada pelaksanaan evaluasi yang dirasakan oleh dosen dalam mata kuliah keahlian khususnya dalam hal ini pada mata kuliah Evaluasi Program.