bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance characterization of a traditional wood‐fired pizza oven
Authors: Falciano Aniello , Masi Paolo , Moresi Mauro 
Published: August 2022

AbstractNeapolitan pizza, a renowned Italian food recognized as one of the traditional specialties guaranteed (TSG) by European Commission Regulation no. 97/2010, should be exclusively baked in wood‐fired ovens for approximately 90 s. Despite its extensive use in restaurants and rotisserie shops all around the world, such equipment has been very poorly studied thus far. The aims of this study were to characterize the operation of a pilot‐scale wood‐fired pizza oven from its start‐up phase to its baking operation and assess its thermal efficiency. To manage brick firing, the oven was lighted at a firewood feed rate (Qfw) of 3 kg/h for just 1 h on the first day, 2 h on the second day, 4 h on the third day, and approximately 8 h on the fourth day. Independent of its lighting frequency, after 4‐6 h, the oven vault or floor temperature approached an equilibrium value of 546 ± 53°C or 453 ± 32°C, respectively. The initial oven floor temperature gradient was linearly related to Qfw, while the maximum floor temperature tended to an asymptotic value of 629 ± 43°C at Qfw = 9 kg/h. The well‐known water boiling test was adapted to assess the heat absorbed by a prefixed amount of water when the pizza oven was operating in pseudosteady‐state conditions at Qfw = 3 kg/h. The thermal efficiency of this oven was 13 ± 4%, and this value was further confirmed by other baking tests with four different white and tomato pizza products.Practical ApplicationAlthough wood‐fired pizza ovens are largely used all over the world, little is known about their transitory and pseudosteady‐state regime performance. This study shows how to perform the start‐up procedure of pilot‐scale equipment and, independent of the operator's ability, how to achieve pseudosteady‐state conditions using different firewood feed rates. Finally, its thermal efficiency was assessed by water heating and pizza baking tests, which allowed a rough estimation of firewood consumption.
Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites
Authors: Ding He , Wang Youyuan , Li Zhiqiang , Li Qianqing , Liu Hongyu , Zhao Jing , Lu Wenfa , Wang Jun 
Published: August 2022

AbstractEndometritis is persistent inflammation caused by bacteria, which can lead to infertility. Although traditional Chinese medicine (TCM) has been used to treat endometritis, the underlying mechanism is still unclear. Here, Baogong Decoction (BGD), a TCM compound, was used to treat mouse endometritis induced byEscherichia coli(E. coli), and then 16S rRNA sequencing and non‐targeted metabolomics were used to investigate the change of uterine microbiota and metabolomes in serum and uterine after BGD treatment. Finally, the therapeutic effect of potential metabolites for treating mouse endometritis screened by combined omics analyses was verified using pathological model. The results showed that BGD treatment could effectively treat endometritis associated with the increasing relative abundance of Firmicutes,Bacteroides,LactobacillusandLactococcus, and the decreasing relative abundance ofCupriavidusand Proteobacteria. 133 and 130 metabolites were found to be potential biomarkers in serum and uterine tissue respectively. In serum and tissues, dehydroepiandrosterone (DHEA) and catechol were significantly increased in the BGD treatment versus the inflammation group. Results of combined omics analyses demonstrated that DHEA was positively correlated with changes in microbiota. Results of pathological model demonstrated that DHEA could cure endometritis effectively associated with the decreasing infiltration of inflammatory cells and expression of inflammatory factors in the uterus. In summary, our results demonstrated that BGD could cure endometritis in mice by modulating the structure of the uterine microbiota and its metabolites, in which DHEA may be one of the main components of the therapeutic effect of BGD.
Emerging role of EZH2 in rheumatic diseases: A comprehensive review
Authors: Xu Wang‐Dong , Huang Qi , Huang An‐Fang 
Published: August 2022

AbstractEnhancer of zeste homolog 2 (EZH2) is a histone methylated enzyme. It trimethylates histone 3 lysine 27 (H3K27) to regulate epigenetic processes. Recently, studies showed excessive expression of EZH2 in rheumatic diseases, such as systemic lupus erythematosus, rheumatoid arthritis, osteoarthritis, and systemic sclerosis. Moreover, epigenetic modification of EZH2 regulates differentiation and proliferation of different immune cells. Therefore, in this review, we comprehensively discuss the role of EZH2 in rheumatic diseases. Collection of the evidence may provide a basis for further understanding the role of EZH2 and give potential for targeting these diseases.
Fraud Firms' Non‐Implicated CFOs: An Investigation of Reputational Contagion and Subsequent Employment Outcomes*
Authors: Condie Eric R. , Convery Amanda M. , Zehms Karla M. 
Published: August 2022

ABSTRACTWe investigate labor market consequences for CFOs employed by fraud firms, focusing on reputational contagion for those who are not implicated. These individuals provide an opportunity to understand reputational contagion and the nuanced meaning of “guilt” because the labor market may suspect complicity or infer negligence regardless of whether that is truly the case. We compare these CFOs to a matched sample of non‐fraud CFOs and track both turnover and subsequent employment positions. Non‐implicated CFOs are more likely to experience turnover compared to non‐fraud CFOs, driven in particular by the public revelation of fraud to the labor market. We further find that non‐implicated CFOs are more likely to obtain comparable subsequent employment than non‐fraud CFOs before the fraud is publicly revealed, but not after. In supplementary analyses, we find that turnover rates are highest for non‐implicated CFOs who started their employment with the firm before the fraud began as compared to non‐implicated CFOs who started their employment after the fraud began. These results highlight the labor market significance of the public revelation of fraud and imply that the labor market does not fully distinguish between fraud firm association and general firm performance when making executive hiring decisions.
Quality of life impact and treatment response in vulval disease: Comparison of 3 common conditions using the Vulval Quality of Life Index
Authors: Wu Michelle , Kherlopian Ashod , Wijaya Marlene , Fischer Gayle 
Published: August 2022

AbstractBackground/ObjectivesTo compare the quality of life in patients with vulval lichen sclerosus (VLS), vulval lichen planus (VLP) and chronic vulvovaginal candidiasis (CVVC), as measured by the Vulval Quality of Life Index (VQLI).MethodsA retrospective, single‐centre cohort study was conducted at a combined dermatology and gynaecology practice from March 2018 to November 2021. VQLI scores and patient data were systematically collected and recorded in an online patient database. Treatment regimens were individualised and titrated to clinical response.ResultsOver 3 years, a total of 200 women were recruited: 59 with CVVC, 79 with VLP and 62 with VLS. The median duration of follow‐up for all patients was 45.43 (16.25–80.89) weeks. At baseline, the median (interquartile range [IQR]) VQLI score was 24.00 (19.00–31.00), 21.00 (12.00–26.00) and 14.00 (7.00–26.00) for CVVC, VLP and VLS, respectively. At follow‐up, the median (IQR) VQLI score for CVVC, VLP and VLS was 9.00 (3.00–15.00), 9.00 (3.00–16.00) and 5.00 (2.00–10.00), respectively. All three groups showed a significant improvement in VQLI score (p < 0.0001). At baseline, the highest scoring domains were ‘Sexual Function’ for CVVC and ‘Future Health Concerns’ for VLP and VLS. At follow‐up, the highest scoring domains were ‘Sexual Function’ for CVVC and VLP, and ‘Future Health Concerns’ for VLS.Conclusions and RelevanceVulval disease has an immense impact on QOL, especially in patients with CVVC. The VQLI is useful to clinicians in identifying the unique impact of each vulval condition on a patient's QOL in order to provide better patient‐focussed care.
The impact of hidradenitis suppurativa on quality of life is worse than inflammatory bowel disease and myocardial infarction
Authors: Mortimore Alexandra M. , Bullen Alison , McMeniman Erin K. 
Published: August 2022

AbstractQuality of life is severely impacted by Hidradenitis Suppurativa. This cross‐sectional survey based study highlights that the impact of Hidradenitis Suppurativa on quality of life measured by the World Health Organisation Quality of Life (WHOQOL‐BREF) survey is worse than published data for atopic dermatitis and other acute and chronic medical conditions including myocardial infarction and inflammatory bowel disease.
Analysis of a national difficult airway database
Authors: Sajayan A. , Nair A. , McNarry A. F. , Mir F. , Ahmad I. , El‐Boghdadly K. 
Published: August 2022

SummaryDifficult airway management continues to adversely affect patient care and clinical outcomes and is poorly predicted. Previous difficult airway management is the most accurate predictor of future difficulty. The Difficult Airway Society initiated a national airway database to allow clinicians to access details of previous difficult airway episodes in patients issued with a difficult airway alert card. We aimed to analyse this database, reporting patient characteristics, airway management and patient outcomes. We included all living adult patients reported in the first 5 years of the database (n = 675). Clinical airway assessment was reported in 634 (94%) patients, with three or more parameters assessed in 488 (72%). A history of difficult airway was known in 136 (20%) patients and difficult airway management was anticipated in 391 (58%). In all, 75 (11%) patients had an airway‐related critical incident, with 1 in 29 being awoken from anaesthesia, 1 in 34 requiring unplanned or prolonged stay in the intensive care unit and 1 in 225 needing an emergency front‐of‐neck airway or had a cardiac arrest/peri‐arrest episode. Airway‐related critical incidents were associated with out‐of‐hours airway management, but no other associations were apparent. Our data report the first analysis of a national difficult airway database, finding that unanticipated difficult airway management continues to occur despite airway assessment, and the rate of critical incidents in this cohort of patients is high. This database has the potential to improve airway management for patients in the future.
Understanding and treating ejaculatory dysfunction in men with diabetes mellitus
Authors: Desai Ankit , Chen Runzhi , Cayetano Axel , Jayasena Channa N. , Minhas Suks 
Published: August 2022

AbstractDiabetes mellitus is a rapidly rising metabolic disorder with important systemic complications. Global figures have demonstrated the prevalence of diabetes mellitus has almost quadrupled from 108 million in 1980 to 422 million in 2014, with a current prevalence of over 525 million. Of the male sexual dysfunction resulting from diabetes mellitus, significant focus is afforded to erectile dysfunction. Nevertheless, ejaculatory dysfunction constitutes important sexual sequelae in diabetic men, with up to 35%–50% of men with diabetes mellitus suffering from ejaculatory dysfunction. Despite this, aspects of its pathophysiology and treatment are less well understood than erectile dysfunction. The main disorders of ejaculation include premature ejaculation, delayed ejaculation, anejaculation and retrograde ejaculation.Although ejaculatory dysfunction in diabetes mellitus can have complex multifactorial aetiology, understanding its pathophysiological mechanisms has facilitated the development of therapies in the management of ejaculatory dysfunction. Most of our understanding of its pathophysiology is derived from diabetic animal models; however, observational studies in humans have also provided useful information in elucidating important associative factors potentially contributing to ejaculatory dysfunction in diabetic men. These have provided the potential for more tailored treatment regimens in patients depending on the ejaculatory disorder, other co‐existing sequelae of diabetes mellitus, specific metabolic factors as well as the need for fertility treatment.However, evidence for treatment of ejaculatory dysfunction, especially delayed ejaculation and retrograde ejaculation, is based on low‐level evidence comprising small sample‐size series and retrospective or cross‐sectional studies. Whilst promising findings from large randomised controlled trials have provided strong evidence for the licensed treatment of premature ejaculation, similar robust studies are needed to accurately elucidate factors predicting ejaculatory dysfunction in diabetes mellitus, as well as for the development of pharmacotherapies for delayed ejaculation and retrograde ejaculation. Similarly, more contemporary robust data are required for fertility outcomes in these patients, including methods of sperm retrieval and assisted reproductive techniques in retrograde ejaculation.
Comparison of primiparous womenʼs childbirth experience in labor induction with cervical ripening by balloon catheter or oral misoprostol – a prospective study using a validated childbirth experience questionnaire (CEQ) and visual analogue scale (VAS)
Authors: Place Katariina , Kruit Heidi , Rahkonen Leena 
Published: August 2022

AbstractIntroductionPrimiparity and labor induction, especially when cervical ripening is required, are risk factors for a negative childbirth experience. Our aim was to compare childbirth experience in primiparous women with cervical ripening by balloon catheter or oral misoprostol using the validated Childbirth Experience Questionnaire (CEQ). We also wanted to compare assessment of a negative childbirth experience by visual analogue scale (VAS) and CEQ.Material and methodsThis is a prospective study of 362 primiparous women undergoing cervical ripening and labor induction by balloon catheter (67.4%) or oral misoprostol (32.6%) at Helsinki University Hospital, Finland, between January 1, 2019 and January 31, 2020. After delivery, the women assessed their childbirth experience using the CEQ, and patient records provided the patient characteristics, delivery outcomes and VAS ratings. We analyzed the results using IBM SPSS Statistics.ResultsOverall, the women experienced their labor and delivery rather positively, with a mean CEQ score of 2.9 (SD 0.6) (scale 1–4), and no differences were detectable when comparing women with cervical ripening by balloon catheter or misoprostol. However, women with balloon catheter were more often satisfied with the method chosen for them and would choose the same method in a future pregnancy. Compared with CEQ, VAS seems mainly to reflect the women's perception of their own capacity to give birth and the safety of the hospital setting, not the level of professional support or participation in decision‐making. According to our results, CEQ and VAS are comparable, but the usability of the CEQ is limited by its inability to distinguish the most negative and the most positive experiences, and the VAS is limited by its simplicity.ConclusionsWomen with cervical ripening by balloon catheter or oral misoprostol experienced their childbirth rather positively, results being similar in both groups. However, women with cervical ripening by balloon catheter were more content with their labor induction. The CEQ and VAS can both be used to assess the childbirth experience of primiparous women undergoing labor induction, but both methods have limitations.
Signalling, screening and costly misrepresentation
Authors: Deneckere Raymond , Severinov Sergei 
Published: August 2022

AbstractWhen misrepresenting private information is costly and each type has a different “natural” least‐cost signal or message, the availability of multiple signals has a significant effect on signalling equilibria and on the set of implementable outcomes in a screening context. In particular, welfare losses associated with costly signalling disappear as the number of available signals increases, yet at the same time each type is identified with a high degree of precision in every equilibrium satisfying a dominance criterion. In the screening context, we establish conditions under which the principal can implement an arbitrary allocation profile at a small communication cost. This result helps to explain why employers often prefer to screen applicants via multiple interviews rather than via menus of contracts. We also derive an optimal screening mechanism in such a setting. A surprising property of this mechanism is the absence of exclusion.
Associations of alcohol consumption with the risk and surgical outcomes of chronic rhinosinusitis in China: A case–control study
Authors: Wang Xueping , Chen Yibin , Zhu Xiaoyuan , Zhou Yandong , Su Hongxia , Zhao Yulin 
Published: August 2022

AbstractObjectiveTo investigate the associations between weekly alcohol consumption and the risk and surgical outcome of Chronic Rhinosinusitis (CRS).DesignA case–control study.Setting and ParticipantsThe study population consisted of 1095 CRS patients and 909 healthy collected from the first affiliated hospital of Zhengzhou University between May 2018 and December 2019.Main Outcome MeasuresUnconditional multivariate logistic regression analysis and Cox proportional hazards regression analysis were performed to estimate the association of alcohol consumption with the risk and surgical outcomes of CRS. Odds ratios (OR) or hazard ratio (HR) with 95% confidence intervals (CI) were calculated separately. The Kruskal–Wallis test was used to explore the possible molecular mechanisms.ResultsAs compared with nondrinkers, the multivariable‐adjusted OR (95% CI) values of current drinkers consuming 7.5–22 drinks and >22 drinks per week were 2.158 (1.249–3.729) and 5.373 (2.912–9.911), respectively. The rate of mucosal epithelialization after CRS surgery for patients who drank 7.5–22 drinks and >22 drinks per week was lower than that of nondrinkers [HR (95% CI) = 0.487 (0.351–0.675) and 0.252 (0.184–0.346), respectively]. The association of alcohol consumption with the risk and surgical outcome of CRS was dose dependent (p < .01). Alcohol consumption increased the risk of CRS and extended the time of mucosal epithelialization after CRS surgery by possibly increasing serum IgE levels (p < .05).ConclusionHigher alcohol consumption of >7.5 drinks per week was an independent risk factor for CRS and extended the time of mucosal epithelialization after surgery. As a potential underlying mechanism, alcohol consumption increases serum IgE levels.
Manufacturing with pluripotent stem cells (PSConf 2021): Key issues for future research and development
Authors: Stacey Glyn N. , Cao Jingyi , Hu Baoyang , Zhou Qi 
Published: August 2022

AbstractHuman pluripotent stem cells (hPSC) have the capability to deliver novel cell‐based medicines that could transform medical treatments for a wide range of diseases including age‐related degenerative disorders and traumatic injury. In spite of significant investment in this area, due to the novel nature of these hPSC‐based medicines, there are challenges in almost all aspects of their manufacturing including bioprocessing, characterization and delivery. The Chinese Academy of Sciences and the Chinese Society for Stem Cell Research have collaborated to create a new discussion forum called PSConf 2021 (Pluripotent Stem Cell Conference 2021), intended to promote exchanges in communication on cutting‐edge developments and international coordination in hPSC manufacturing. The PSConf 2021 addressed crucial topics in stem cell‐based manufacturing, including stem cell differentiation, culture scale‐up, product formulation and release. This report summarizes the proceedings and conclusions from the discussion sessions, and it is accompanied by publication of individual papers from the speakers at the PSConf 2021.Significance StatementThe PSConf 2021 meeting has brought together speakers and delegates from more than 20 countries in an informal discussion forum focusing on the manufacture of cell‐based medicines using hPSCs. The conference discussion sessions enabled an open exchange of information on the latest developments, ideas on key challenges and their potential solutions. It also captured the experiences and lessons learnt by professionals who had been in the field from the earliest applications of human embryonic stem cells, and presented a diverse range of new potential pluripotent stem cell‐based medicines that are now under development, with some already in clinical trials.
Evaluation of the Iranian panel reactive antibody calculator and potential usefulness: A retrospective study
Authors: Mohammadzadeh Sahand , Jaladat Abdul Reza , Mohammadi Maryam , Geramizadeh Bita , Anbardar Mohammad Hossein , Soleimani Neda , Amirinezhad Fard Elahe , Tehrani Narges Jamshidian 
Published: August 2022

AbstractBackground and ObjectivesThere are several cPRA websites based on large enough samples in Eurotransplant, the United Network for Organ Sharing (UNOS), and the Canadian Transplant Registry (CTR). On the other hand, those calculators can differ based on the ethnicity to which they are applied. We developed the Iranian PRA calculator and compared it with UNOS and CTR calculators.MethodsThe allele and haplotype frequencies of the Iranian donor pool were estimated using the HLA typing of 523 deceased Iranian kidney donors. The Organ Procurement and Transplantation Network formula was used to generate cPRA (cPRA frequency). We also used a computer script to compare the undesirable antigens of patients with the human leukocyte antigen (HLA) phenotype of donors (cPRA filtering). A total of 100 anti‐HLA antibody profiles were determined in 100 sensitized individuals on the waiting list, and cPRA was estimated using various PRA calculators.ResultsVariable allelic frequencies were obtained from population heterogeneity in each calculator's donor panel. However, no significant changes in cPRA were identified between the Iranian calculator, UNOS, and the Canadian online calculators. Lin's concordance correlation coefficient of .98 showed that cPRA (freq) and cPRA (filter) values had almost perfect agreement.Interpretation and ConclusionThe cPRA values from the Iranian calculator are comparable to those from UNOS and CTR calculators. The donor filtering method was more useful because of factors like cost and flexibility. It also makes it easier to update cPRA on a regular basis.
Supporting the Interpretive Validity of Student‐Level Claims in Science Assessment with Tiered Claim Structures
Authors: Student Sanford R. , Gong Brian 
Published: August 2022

AbstractWe address two persistent challenges in large‐scale assessments of the Next Generation Science Standards: (a) the validity of score interpretations that target the standards broadly and (b) how to structure claims for assessments of this complex domain. The NGSS pose a particular challenge for specifying claims about students that evidence from summative assessments can support. As a solution, we propose tiered claims, which explicitly distinguish between claims about what students have done or can do on test items—which are typically easier to support under current test designs—and claims about what students could do in the broader domain of performances described by the standards, for which novel evidence is likely required. We discuss the positive implications of tiered claims for test construction, validation, and reporting of results.