bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leakage threshold of a saddle point
Authors: Huang De , Yan Xiang , Larsson Roland , Almqvist Andreas 
Published: September 2022

Abstract
The threshold condition for leakage inception is of great interest to many engineering applications, and it is essential for seal design. In the current study, the leakage threshold is studied by means of a numerical method for a mechanical contact problem between an elastic bisinusoidal surface and a rigid flat surface. The coalesce process of the contact patches is first investigated, and a generalized form of solution for the relation between the contact area ratio and the average applied pressure is acquired. The current study shows that the critical value of the average applied pressure, required to close the percolation path, can be represented as a power law of a shape parameter if the effect of the hydrostatic load from the pressurized fluid is ignored. With contact patches merged under a constant applied load, the contact breakup process is investigated under elevated sealed fluid pressure conditions, and it is shown that the leakage threshold is a function of the excess pressure, which is defined as a ratio between the average applied pressure and the critical pressure under dry contact conditions.
Expression and Purification of Human Granzyme B Fusion Protein to
Induce Targeted Apoptosis in PSMA Positive Prostate Cancer Cells
Authors: Hadi Mahdieh , Akbari Amir , Dehbidi Gholamreza Rafiei , Arabsolghar Rita , Bahmani Taraneh 
Published: September 2022

Background:
Granzyme B can induce apoptosis in target cells by direct and indirect
activation of caspases and cleavage of central caspase substrates. Prostate-specific membrane
antigen (PSMA) is a type II transmembrane glycoprotein and its expression increases following
prostate cancer progression.

Objective:
In this study, we designed a fusion protein including mutant granzyme B, the influenza
virus hemagglutinin HA-2 N-terminal, and PSMA ligand to construct GrB-HA-PSMA ligand fusion
protein as a molecular agent for selective targeting of PSMA-positive (LNCaP) cells.

Methods:
The DNA sequence of our designed structure was synthesized and cloned into a pET28a
expression vector. The recombinant protein was expressed in E. coli origami bacteria and then
purified. The expression of the recombinant protein was verified by SDS PAGE and ELISA
method. Furthermore, ELISA and flow cytometry assays were utilized to investigate the efficiency
of binding and permeability of the recombinant protein into the LNCaP cells. Finally, cell
proliferation and apoptosis rate were evaluated by MTT assay and flow cytometry assay,
respectively. HeLa and PC3 cell lines were used as controls.

Results:
The results showed that GrB-HA-PSMA ligand fusion protein could specifically bind and
internalize into the PSMA-positive cells. Furthermore, treatment of the cells with GrB-HA-PSMA
ligand fusion protein resulted in increased apoptotic cell death and decreased proliferation of
LNCaP cells.

Conclusion:
Our findings indicate the specificity of GrB-HA-PSMA ligand fusion protein for
PSMA-positive cells and suggest that this fusion protein is a potential candidate for prostate cancer
targeted therapy.
Mechanism of Action and Implication of Naphthoquinone as Potent Anti-trypanosomal Drugs
Authors: Rani Ruma , Sethi Khushboo , Gupta Snehil , Varma Rajender S. , Kumar Rajender 
Published: September 2022

Abstract:Naphthoquinone is a heterocyclic moiety whose natural derivatives are present as bioac-tive compounds in many plants and have stimulated a resurgence of interest in the past decades due to their wide range of pharmacological activities. Naphthoquinone agents have dynamic pharmaco-phores and privileged sub-structures in the chemistry of medicine. They have received much interest in drug discovery as trypanocidal because naphthoquinone and their derivatives revealed massive significance potential against the trypanosomes. Among natural naphthoquinones, lapachol, β-lapachone and its α-isomer exhibited useful trypanocidal activities. Some naphthoquinones have already been used commercially as an antiparasitic agent. Several naphthoquinones with diverse structural motifs have been synthesized and evaluated mainly against Trypanosoma cruzi and some studies have also been reported against Trypanosoma brucei and Trypanosoma evansi. This review summarized various mechanisms of action of naphthoquinone like reductive activation of quinone by the production of the semiquinone, generation of reactive oxygen species and free radicals such as superoxide anion radical and H2O2, and oxidative stress in the parasite. The information assembled in this review will help to understand the mechanism behind the activity and may also be useful to find the bio-efficacy of naphthoquinone compounds upon substitution against trypanoso-matids.
Understanding Mental Health Apps for Youth: Focus Group Study With Latinx Youth
Authors: Agapie Elena , Chang Katherine , Patrachari Sneha , Neary Martha , Schueller Stephen M 
Published: September 2022

Background
An increasing number of mental health apps (MHapps) are being developed for youth. In addition, youth are high users of both technologies and MHapps. However, little is known about their perspectives on MHapps. MHapps might be particularly well suited to reach the youth underserved by traditional mental health resources, and incorporating their perspectives is especially critical to ensure such tools are useful to them.

Objective
The goal of this study was to develop and pilot a process for eliciting youth perspectives on MHapps in a structured and collaborative way. We also sought to generate learnings on the perspectives of Latinx youth on MHapps and their use in ways that might facilitate discovery, activation, or engagement in MHapps, especially in Latinx populations.

Methods
We created a series of focus groups consisting of 5 sessions. The groups introduced different categories of MHapps (cognitive behavioral therapy apps, mindfulness apps, and miscellaneous apps). Within each category, we selected 4 MHapps that participants chose to use for a week and provided feedback through both between-session and in-session activities. We recruited 5 youths ranging in age from 15 to 21 (mean 18, SD 2.2) years. All the participants identified as Hispanic or Latinx. After completing all 5 focus groups, the participants completed a brief questionnaire to gather their impressions of the apps they had used.

Results
Our focus group methodology collected detailed and diverse information about youth perspectives on MHapps. However, we did identify some aspects of our methods that were less successful at engaging the youth, such as our between-session activities. The Latinx youth in our study wanted apps that were accessible, relatable, youth centric, and simple and could be integrated with their offline lives. We also found that the mindfulness apps were viewed most favorably but that the miscellaneous and cognitive behavioral therapy apps were viewed as more impactful.

Conclusions
Eliciting youth feedback on MHapps is critical if these apps are going to serve a role in supporting their mental health and well-being. We refined a process for collecting feedback from the youth and identified factors that were important to a set of Latinx youth. Future work could be broader, that is, recruit larger samples of more diverse youth, or deeper, that is, collect more information from each youth around interests, needs, barriers, or facilitators or better understand the various impacts of MHapps by using qualitative and quantitative measures. Nevertheless, this study advances the formative understanding of how the youth, particularly Latinx youth, might be viewing these tools.
Niveles de interleucina 23 (IL-23) en saliva de niños con dentición mixta temprana: estudio piloto
Authors: Noyola Sánchez Paulina , Guerrero Velázquez Celia , Hernández Troncoso Rita Stephanie , Malespin García Karla Elizabeth , Chávez Maciel José María , Rodríguez Montaño Ruth 
Published: September 2022

Introducción: En la fase de dentición mixta existe un control entre la erupción y reabsorción dental mediante la osteoclastogénesis y la osteogénesis. Estos procesos están regulados por el eje IL-23/IL-17 y el sistema RANK/RANKL/OPG. Se conoce que la IL-23 tiene un papel crucial en la producción de IL-17 y RANKL entre otras citoci- nas. La IL-17 activa diferentes células inmunes y no inmunes como los fibroblastos y éstos a su vez pueden secretar RANKL. Esto indi- ca que la IL-23 de forma directa e indirecta estimula la producción de RANK, el cual da paso a la activación de los osteoclastos. Obje- tivo: Evaluar los niveles de IL-23 en saliva de niños en fase de den- tición mixta con clase molar I y II. Material y métodos: Se obtuvo muestra de saliva y se almacenó a -80 oC hasta la determinación de IL-23 mediante ELISA. Resultados: Las concentraciones de IL-23 en saliva no mostraron diferencia significativa entre los niños condentición clase molar I y II. Conclusión: Hasta el momento estos hallazgos indican que la regulación de la IL-23 en este proceso fi- siológico no difiere de acuerdo al tipo de oclusión molar.
New Method to Assess and Enhance Athletes’ Performance Based on Muscle Synergy Patterns: A New Approach to Design a Biofeedback Training Scheme
Authors: Hakkak Moghadam Torbati Armin , Gholibeigi Mohammadamin , Jami Shahab 
Published: September 2022

Objectives: There has been a big challenge for athletes at any level to reach their ultimate performance. According to a Motor Control theory, accurate programming of movements during the last stage of preparation to work out can improve athletes' performance. So, this study aims to design a performance analysis method that can be used to classify athletes and give them feedback during exercise. In this way, athletes and coaches can consider exercise schemes to modify and ameliorate athletes' performance.
Methods: The participants were made up of 20 men between 25 to 30 years old. These subjects include ten professional football players and ten amateur football players. The same trials in 6 successive days were done by all athletes, both professional and amateur. Two different types of conditions were designed for all participants. In the first three days, subjects were asked to shoot a penalty kick (football player) 10 times in an actual situation like what they do in a competition. These procedures were done in the simulation condition, in the next three days designed by the computer (Xbox). Surface electromyography (sEMG) was recorded from the gastrocnemius and tibialis anterior muscles during trials.
Results: Results showed the maximum error between basis vectors in all of the professional subjects in each situation, real and game, were 0.48 and 0.37, respectively (Mean square error index), which are very low relative to the range of data (5.1). In contrast, the minimum error among amateurs in each situation was 13.18 and 18.72, which are a high amount compared with the range of data (7).
Discussion: Professional athletes always, in both situations, use their muscles in the same way. In fact, professional athletes' muscles follow specific patterns due to slight errors, while amateurs' muscles do not.
Ambulatory Phlebectomy: sixty-year-old but still looking great
Authors: Ricci Stefano 
Published: September 2022

Ambulatory Phlebectomy (AP), conceived by Robert Muller starting from 1956, initially considered with great scepticism, became completely accepted and employed at the end of the XX century.
AP may be employed in three strategic perspectives related to the Saphenous Veins (SV) situation:
-	In the course of SV stem incompetence treatment, either as a concomitant or a staged treatment of dilated tributaries. Both positions seem to have valid (different) reasons.
-	As a first step avoiding SV incompetence treatment, as in CHIVA or in ASVAL methods, although with different hemodynamic bases.
-	As an isolated procedure when SV is not involved.
AP is a simple technique, easily office based, effective and safe, provided basic rules are followed (local anaesthesia, US assessment, correct mapping, small incisions, no sutures, post-op. compression); however, it is highly related to manual skill (together with patience, concentration and delicate touch), results depending heavily on details and less on routine.
Experiencias en la construcción de masculinidades de estudiantes en escuelas secundarias. Discusiones teóricas preliminares para su abordaje
Authors: Pannelli Ezequiel M. 
Published: September 2022

La presente comunicación es un análisis de discusiones y recursos teóricos en el marco de la investigación en curso “Modos de ser varón en dos escuelas secundarias. Experiencias de construcción de masculinidades en el partido de La Matanza”. Se analiza la situación del marco socio-político-cultural en el que se inscribe y se hace un recuento de trabajos previos. Se revisa cómo las escuelas han impartido educación sexual históricamente y cómo la cuarta ola feminista impactó en ellas.
Se desarrollan luego las consideraciones teóricas necesarias para comprender la construcción socio-histórica del género y las masculinidades. Por último, se analizan los aportes conceptuales de la categoría experiencia en tanto operador analítico para el trabajo en cuestión.
On the Edge - future adaptation challenges: The role of futurology, scenario planning methodology and off grid design in architectural and urban teaching
Authors: Zedníčková Zdeňka Němcová 
Published: September 2022

Abstract
The article describes the role of thinking about the future and its importance in architectural and urban education. The first part deals with the scientific discipline of futurology and the possibilities of its use in architectural and urban practice. It covers topics that futurology makes available to architecture and their influence on the urbanized environment. It relates the creation of strategic visions for urban development with the UN 2030 Agenda for Sustainable Development and the UN Habitat III initiative. The second part is dedicated to introducing the futurological method of scenario planning, and its origin and use. It mentions so-called megatrends as the driving forces of future scenarios, effecting future challenges and threats that cities will have to deal with. Further, it provides insight into how this method can benefit architectural and urban work and represents the way it was used during architectural teaching. It reflects on the advantages of creating visions in the educational process. In the last part, it shows the off-grid design as a suitable simulator of structural and system thinking, leading to a better understanding of how complex architectural and urban systems function. It highlights the contribution of space architecture projects as a source of innovative thinking. It anticipates that working on space projects where self-sufficiency is a necessity can also benefit thinking about ecology, self-sufficiency, and the sustainability of settlements on Earth.
Linking virtual reality, architecture, and crime prevention for educational purposes
Authors: Benkovičová Lucia 
Published: September 2022

Abstract
This paper presents selected links between the complex fields of architecture, use of virtual reality (as a part of computer science), and their potential in helping tackle crime. The presented information sets a general background for the development of a put forward prototype of new immersive learning experience to provide deeper understanding of CPTED concepts to enhance the traditional curriculum and the overall retention of knowledge. In architecture, better computer technology raises the stakes. Architecture’s side of communicating ideas and managing information has been reflected in BIM. Technology is one component of larger social, economic, and business revolutions that will continue to have a substantial impact on the markets in which architects deliver services. Technological progress enables blurring the boundaries between reality and the virtual world. It is a source of inspiration and some freedom in architectural design. The theory of education is also influenced by new technologies. There are scientific studies suggesting learning in virtual reality may be more efficient than in the real world. Current VR systems provide new features for perceptual expansion, for creative construction, and for unique social interactivity. There are now hundreds of university architecture programmes with VR and AR labs all over the world. We have also changed the way of designing of and thinking about our cities, including safety. The global nature of crime has brought international cooperation in the field of prevention, one example being the CPTED security concept. New visual stimuli, such as VR, may broaden our understanding of housing design, burglary risk and CPTED, and help prevent crime. VR has also pedagogical promise, as it can be used not only to assess hypothetical environments, but also to track, shape and affect subjects’ thinking towards them. There are not many practical studies on the use of VR for this purpose, which points at a niche for more research to be conducted in this area.
Compactness of quadruple band matrix operator and geometric properties
Authors: Bişgin Mustafa Cemil , Sönmez Abdulcabbar 
Published: September 2022

Abstract
In this work, we characterize the class of compact matrix operators from c
0(Q), c(Q) and ℓ
∞ (Q) into c
0, c and ℓ
∞, respectively, with the notion of the Hausdorff measure of noncompactness. Moreover, we determine some geometric properties of the sequence space ℓp
(Q).
Construction of Databases for Small Area Estimation
Authors: Berg Emily 
Published: September 2022

AbstractThe demand for small area estimates can conflict with the objective of producing a multi-purpose data set. We use donor imputation to construct a database that supports small area estimation. Appropriately weighted sums of observed and imputed values produce model-based small area estimates. We develop imputation procedures for both unit-level and area-level models. For area-level models, we restrict to linear models. We assume a single vector of covariates is used for a possibly multivariate response. Each record in the imputed data set has complete data, an estimation weight, and a set of replicate weights for mean square error (MSE) estimation. We compare imputation procedures based on area-level models to those based on unit-level models through simulation. We apply the methods to the Iowa Seat-Belt Use Survey, a survey designed to produce state-level estimates of the proportions of vehicle occupants who wear a seat-belt. We develop a bivariate unit-level model for prediction of county-level proportions of belted drivers and total occupants. We impute values for the proportions of belted drivers and vehicle occupants onto the full population of road segments in the sampling frame. The resulting imputed data set returns approximations for the county-level predictors based on the bivariate model.
The Materialisation of “torrential languages” within the Avant-Garde: Mina Loy, James Joyce, and Aesthetic Modernism
Authors: Wang Bowen 
Published: September 2022

Abstract
Modernist literature was obsessed with a metaphysical problem regarding the word. A series of formal and material experiments started to address the word’s self-referentiality and aesthetic autonomy, against the backdrop of a new sociocultural milieu in the early twentieth century. To discover how this materialisation of language explored the interplay of literary and artistic modernisms, this paper will critically scrutinise Mina Loy’s and James Joyce’s radical reforms of writing and try to answer the following questions: how did Loy’s multifarious artisthood and poem-writing exchange, interact with, and reinforce each other? As both were closely associated with avant-garde art movements between Europe and America, how did Joyce influence Loy’s refashioning of “torrential languages” (LoLB 88) as a creative model of linguistic experimentation? How did their visual aesthetics and experimental poetics help to declare the independence of language and the shape of aesthetic modernism in a new historical epoch?
The “bull goose looney” as a Totem Guide for Chief’s Writing Himself to Freedom
Authors: Somerville Matthew 
Published: September 2022

Abstract
This paper examines the institutionalisation of psychiatric treatment in Ken Kesey’s One Flew Over the Cuckoo’s Nest. Taking up the work of Michel Foucault, the paper examines how those suffering from mental illness were classified as disruptive and unfit for society, subsequently labelled mad and institutionalised in facilities more akin to semi-judicial structures than medical facilities. McMurphy, having manipulated a transfer for himself from a state work farm to what he perceives will be the less rigorous confines of a mental institution, epitomises the disruptive presence of the madmen, bringing a world of disorder and chaos to the staff and patients of the mental ward. Self-proclaimed as the head “bull goose looney”, McMurphy reflects the counter-culture movements of the 1960s in the United States in his rejection of the rules and regulations imposed upon him by what amounts to a totalitarian system of control. A wild indomitable force of nature, McMurphy becomes a totem for Chief and the other patients, an embodiment of the human spirit the patients have forfeited inside the institutional system.
Naomi Alderman’s The Power: A Speculative Feminist Dystopian Fiction Mirroring the Here and Now
Authors: Sen Tuhin Shuvra 
Published: September 2022

Abstract
Speculative fiction, containing speculative elements based on supposition and imagination, changes the dynamics of what is real or possible as we perceive them in our current world and then surmises the likely consequences. Litterateurs have employed speculative fiction as a means of suggesting the latent possibilities and promises for our immediate reality which are not yet enacted or materialised. Accordingly, female writers of feminist speculative fiction, particularly from the 1970s onwards, have used this genre as an effective tool both to expose and to interrogate the oppressive status quo and the normative ethos of the conventional power relation between the sexes prevailing at present. In keeping with this, Naomi Alderman, in her Bailey’s Women’s Prize for Fiction 2017 winning novel The Power, strategically flips the current power structure between the sexes on its head by investing the women, primarily adolescent girls, with the unforeseen yet inherent power of electrocuting men which ultimately results in a Cataclysm initiating a new world order ruled and dominated by empowered women some time in the future. This paper aims at exploring how Alderman, a staunch feminist, purposefully demonstrates in The Power that her novel’s fictional dystopia, though macabre and gruesome, is, in essence, a fairly accurate representation as well as a critique of the hierarchical gender relationship as it is prevalent in our present reality.