bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival
Authors: Kütting Fabian , Gebauer Florian , Zweerink Susanne , Krämer Laurenz , Schramm Christoph , Quaas Alexander , Bruns Christiane , Goeser Tobias , Nierhoff Dirk 
Published: March 2022

AbstractCurrent recommendations suggest neoadjuvant treatment in node-positive esophageal cancer or tumors staged T3 and upwards but some T2 N0 patients might benefit from neoadjuvant therapy. It is of clinical relevance to identify this subgroup. Loss of epithelial apicobasal polarity is a key factor in the development of invasive capabilities of carcinoma. The oncofetal stem/progenitor cell marker NOPE is expressed in adult depolarized murine hepatocytes and in murine/human hepatocellular carcinoma. We analyzed NOPE expression in 363 patients with esophageal adenocarcinoma using an RNA Scope Assay on a tissue microarray and correlated results with clinical data. Median follow-up was 57.7 months with a 5-year survival rate of 26.6%. NOPE was detectable in 32 patients (8.8%). In pT1/2 stages, NOPE expression was associated with a significantly reduced median OS of 6.3 months (95% CI 1.2–19.4 months), the median OS is not reached in the NOPE-negative group (calculated mean OS 117.1 months) (P = 0.012). In advanced tumor stages, a NOPE dependent survival difference was not detected. This is the first report of NOPE expression demonstrating a prognostic value in esophageal cancer. Early stage, NOPE positive patients are at a high risk of tumor progression and may benefit from neoadjuvant treatment analogous to advanced stage cancer.
Density of invasive western honey bee (Apis mellifera) colonies in fragmented woodlands indicates potential for large impacts on native species
Authors: Cunningham Saul A. , Crane Mason J. , Evans Maldwyn J. , Hingee Kassel L. , Lindenmayer David B. 
Published: March 2022

AbstractFeralApis melliferacolonies are widespread globally and cause ecological impacts as pollinators and competitors for food and nesting opportunities. The magnitude of impact depends on their population density, but knowledge of this density is poor. We document feralA. melliferacolonies at 69 per km2in fragmentedEucalyptuswoodlands in Australia, exceeding estimates from elsewhere in the world, and matched only by one other Australian study. We surveyed 52.5 ha of woodland patches with 357 nest boxes installed to provide nesting opportunities for threatened vertebrates. Our sites covered a region of more than 140 km across with repeated surveys over 3 to 6 years. We show that nest box use by feralA. melliferacolonies is influenced by box design (p = 0.042), with weak evidence for an interactive effect of type of vegetation at a site (woodland remnants vs. replanting) and woody cover within 500 m (p = 0.091). At 69 colonies per km2, this density is equivalent to the recommended stocking of hives for pollination of some crops and is therefore likely to influence pollination and lead to competition with other flower visitors.Apis melliferais also likely to be competing for hollows with cavity dependent native fauna, especially in landscapes where there has been extensive tree removal.
Hippotherium Datum implies Miocene palaeoecological pattern
Authors: Sun Boyang , Liu Yan , Chen Shanqin , Deng Tao 
Published: March 2022

AbstractHere, we report well–preserved skulls and postcranial specimens of genus Hippotherium from the Linxia Basin, Gansu, China. Based on morphological comparison, the species of Hippotherium in China, Hippotherium weihoense and Hippotherium chiai, should be ascribed to the same species, H. weihoense. We also reviewe other Old World hipparion species in the very early Late Miocene and figure out two evolutionary routes: the Hippotherium and Cormohipparion lineages. Analysis of locomotive ability indicates that H. weihoense likely lived in an open habitat, whereas other species of Hippotherium likely lived in closed habitats. This result shows a palaeoecological pattern in the early Late Miocene in Eurasia influenced by a series of geological events as aridification of mid–latitude Asia progressed, whereas Europe and North Africa remained relatively humid. As the genus originated from East Asia, hipparion horses divided rapidly into different groups with differing functional morphology to occupy diverse niches.
Chemical vapor deposition-grown nitrogen-doped graphene’s synthesis, characterization and applications
Authors: Deokar Geetanjali , Jin Junjie , Schwingenschlögl Udo , Costa Pedro M. F. J. 
Published: March 2022

AbstractThe physical properties of carbon materials can be altered by doping. For instance, the electronic properties of graphene can be modulated by controlling the substitutional doping of the carbon lattice with N. In addition, C–N bonding configurations with three ring types are recognized: pyridinic-N, pyrrolic-N, and graphitic-N. Controlling the type and relative density of various types of substitutional N is an important objective that requires an extremely high level of precision when the atomic lattice is constructed. This control can be accomplished only via bottom-up methods, such as chemical vapor deposition (CVD). The number of reports on N-doped graphene (NDG) grown via CVD has increased over the past decade, but a reliable wafer-scale production strategy that can realize the desired atomic-precision growth of NDG is still lacking. To identify the most promising strategies and analyze the consistency of the results published in the literature, we review the CVD growth and characterization of two-dimensional NDG and two of the most popular applications of NDG films: field-effect transistors and energy storage devices.
Formation reaction mechanism and infrared spectra of anti-trans-methacrolein oxide and its associated precursor and adduct radicals
Authors: Cai Jia-Rong , Su Jung-Hsuan , Lee Yuan-Pern 
Published: March 2022

AbstractMethacrolein oxide (MACRO) is an important carbonyl oxide produced in ozonolysis of isoprene, the most abundantly-emitted non-methane hydrocarbon in the atmosphere. We employed a step-scan Fourier-transform infrared spectrometer to investigate the source reaction of MACRO in laboratories. Upon UV irradiation of precursor CH2IC(CH3)CHI (1), the CH2C(CH3)CHI radical (2) was detected, confirming the fission of the allylic C‒I bond rather than the vinylic C‒I bond. Upon UV irradiation of (1) and O2 near 21 Torr, anti-trans-MACRO (3a) was observed to have an intense OO-stretching band near 917 cm−1, much greater than those of syn-CH3CHOO and (CH3)2COO, supporting a stronger O‒O bond in MACRO because of resonance stabilization. At increased pressure (86‒346 Torr), both reaction adducts CH2C(CH3)CHIOO (4) and (CHI)C(CH3)CH2OO (5) radicals were observed, indicating that O2 can add to either carbon of the delocalized propenyl radical moiety of (2). The yield of MACRO is significantly smaller than other carbonyl oxides.
Quality of Life in Caregivers, Spouses, and Partners of Total Laryngectomees: A Scoping Review
Authors: St. Peter Madeleine , Ward Christina , Nancy Naomi , Sykes Kevin J. 
Published: March 2022

Purpose:
The purpose of this study was to (a) review methods used to assess quality of life (QOL) in caregivers, partners, and spouses of those who have undergone total laryngectomy (TL); (b) identify patterns in caregiver QOL changes postoperatively; and (c) review previously proposed interventions for caregivers.

Method:

PubMed, EMBASE, and CINAHL Complete were searched using the Medical Subject Heading terms
laryngectomy
,
spouse
,
caregiver
, and
partner
. Two reviewers independently screened and identified records meeting inclusion criteria. This scoping review adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Results:
Initial search returned 143 results and 12 met inclusion criteria. Eight studies assessed postoperative QOL changes in categories such as psychological health, physical health, sexuality, and interpersonal relationships. Four studies proposed interventions for caregivers perioperatively. There were no consistently used inventories, and only one intervention was formally tested.

Conclusions:
The literature available on TL caregiver QOL contains inconsistent inventories and study design. There are few interventions available, and it would be beneficial to develop a standardized QOL inventory for this population to better target caregiver needs.

Supplemental Material:

https://doi.org/10.23641/asha.19287887
Impact of the COVID-19 Pandemic on PhD Students in Communication Sciences and Disorders
Authors: Covington Natalie V. , Jordan Larissa M. 
Published: March 2022

Purpose:
The COVID-19 pandemic upended the status quo in higher education, causing rapid and unprecedented instructional, social, and financial changes. The aim of this exploratory study was to characterize doctoral students' experiences during the pandemic and draw insights that may impact the long-term health of the field of communication sciences and disorders (CSD).

Method:
One hundred sixty current PhD students in CSD completed an online survey. Student perceptions of the pandemic's impacts on their academic progress, future academic careers, and support from their academic programs were analyzed both quantitatively and qualitatively.

Results:
A majority of students indicated that the pandemic had negatively impacted progress through their PhD program. A quarter of respondents reported that their caregiving responsibilities had increased. Of these, the majority said that this increase in caregiving would delay their academic progress. A majority of students had concerns about farther-reaching negative impacts on their academic careers. Students' perceived support from their programs during the pandemic was significantly lower compared to perceived support prior to the pandemic. When asked directly what decision-making stakeholders should know, respondents reported increases in stress and anxiety, a desire that stakeholders would recognize the effect of less-rich academic environments on student training, and the potential that students would leave the academic “pipeline” as a result of pandemic-related delays and stressors. Across multiple open-response questions, students expressed concerns that the negative impacts of the pandemic would be unequally distributed across groups, such that existing inequalities in academia would be further exacerbated by the pandemic.

Conclusion:
This study characterizes the lived experiences of PhD students in CSD during the COVID-19 pandemic and provides information that may inform key decision-making stakeholders (advisors, departments, and the American Speech-Language-Hearing Association) as they continue to make changes and accommodations in response to the pandemic.

Supplemental Material:

https://doi.org/10.23641/asha.19294634
Knowledge Brokering in Communication Sciences and Disorders
Authors: Douglas Natalie , Oshita Jennifer , Schliep Megan , Feuerstein Julie 
Published: March 2022

Purpose:
Knowledge brokering is one tool to improve the lines of communication between clinicians and researchers with the ultimate goal of closing the research to practice gap. The following review article outlines definitions of knowledge brokering; describes attributes and activities of knowledge brokering, including domains of knowledge brokering; illustrates data to support the role of knowledge brokering; and provides a tool for teams to reflect upon their own knowledge brokering capabilities.

Conclusions:
Knowledge brokering provides practical tools to decrease the silos between researchers and clinicians with the goal of providing the best care to all the populations that we serve. While we are hopeful that the evidence for knowledge brokering will continue to develop, there are low-risk action items (e.g., active listening, relationship building across boundaries, and appreciation of the diversity of contexts in which clinical services are delivered) that readers could implement immediately.
Intelligent vehicle lateral control based on radial basis function neural network sliding mode controller
Authors: Fan Bailin , Zhang Yi , Chen Ye , Meng Linbei 
Published: March 2022

AbstractBased on the predigestion of the dynamic model of the intelligent firefighting vehicle, a linear 2‐DOF lateral dynamic model and a preview error model are established. To solve the problems of a highly non‐linear vehicle model, time‐varying parameters, output chattering, and poor robustness, the Radial Basis Function neural network sliding mode controller is designed. Then, different driving speeds are used to conduct simulation tests under standard double‐shifting and smooth curve road conditions, and the simulation results are used to analyse the tracking effect of the lateral motion controller on the desired path. The simulation results reveal that the controller designed has high accuracy in tracking the desired path and has good robustness to the disturbance of intelligent firefighting vehicle speed changes.
Protection framework for microgrids with inverter‐based DGs: A superimposed component and waveform similarity‐based fault detection and classification scheme
Authors: Jarrahi Mohammad Amin , Samet Haidar , Ghanbari Teymoor 
Published: March 2022

AbstractSince the penetration level of the inverter‐based distributed generations (IBDGs) into microgrids (MGs) is increasing, the protection issues of such networks have become more challenging. The present work aims to design a protection framework for fault detection and classification in IBDG dominated MGs. In the proposed approach, the current waveforms measured from one end of the protected lines are processed using superimposed components. Then, the faults are identified using the Euclidean distance concept. A Pearson correlation coefficient‐based approach is also developed to characterize the faulty phases in the proposed fault classification unit. Furthermore, an auxiliary index is defined to discriminate load change conditions from the faults. In addition to being simple and efficient, the proposed technique is highly capable of functioning in different MG operating modes and configurations without changing its settings. Also, it demonstrates robust performance against IBDG impacts, noises, and stimulating fault scenarios. To assess the scheme proficiency, a modified IEEE 15‐bus system with highly penetrated IBDGs is simulated. The results confirm the quickness and high accuracy of the proposed technique. Moreover, the method is validated in an experimental laboratory test bench. Finally, the superiority of the method is confirmed by a comparative study with other recent methods.
A new online testing technique for reversible circuits
Authors: Mondal Joyati , Das Debesh Kumar 
Published: March 2022

AbstractAny technology offering zero power dissipation must be reversible. A reversible circuit can be envisaged as a cascade of reversible gates only, such as Toffoli gate, which has two components: k control bits and a target bit (k‐CNOT), k ≥ 1. Analysing testability issues in a reversible circuit is an important phenomenon. A new online design‐for‐testability (DFT) technique for reversible circuits is proposed. The authors’ method yields less overhead in terms of quantum cost as compared to the previous online approaches.
Proximal femur anatomy-implant geometry discrepancies
Authors: Cornelissen Andries Johannes , Ferreira Nando , Burger Marilize Cornelle , Jordaan Jacobus Daniel 
Published: March 2022

Objectives: Due to ongoing concern about femur anatomy-implant mismatches, this cross-sectional study aimed to create a geometric femur profile and used it to identify and quantify possible mismatches between femur anatomy and cephalomedullary nail dimensions. The work further aimed to assess whether patient demographics affect anatomy-implant coherence. Methods: One hundred skeletally mature complete femur computer tomography (CT) scans were collected and exported to software enabling landmark placement and measures with multiplanar reconstruction techniques. Results: Clinically relevant anatomy-implant discrepancies included the femur neck and shaft axis offset 6.1 ± 1.7 mm (95% CI [5.7–6.4]), femur radius of curvature 1.2 ± 0.3 m (95% CI [1.1–1.2]), femur anteversion 18.8 ± 9.2 (95% CI [16.9–20.6]). The implants reviewed in this study did not compensate for the femur neck and shaft axis offset and had a larger radius of curvature than the studied population. Clinically significant demographic geometry differences were not identified. Conclusion: There were discrepancies between femur anatomy and cephalomedullary nail implant design; however, no clinically significant femur feature inconsistency was identified among the demographic subgroups. Due to the identified anatomy-implant discrepancies, including the femur neck and shaft axis offset, we suggest that these measurements be considered for future implant design and surgical technique.
Quasiparticle multiplets and 5f electronic correlation in prototypical plutonium borides
Authors: Lu Haiyan , Huang Li 
Published: March 2022

Abstract
In this paper, we investigate the electronic structures of plutonium borides (PuB
x
, x = 1, 2, 6, 12) to uncover the fascinating bonding behavior and orbital dependent correlations of 5f valence electrons by using the density functional theory combined with single-site dynamical mean-field method. We not only reproduce the correlated topological insulator of PuB6, but also predict the metallicity in PuB
x
(x = 1, 2, 12). It is found that the band structure, density of states, hybridization functions all indicate partially itinerant 5f states in PuB
x
(x = 1, 2, 6, 12). Especially, quasiparticle multiplets induced noteworthy valence state fluctuations implying the mixed-valence behavior of plutonium borides. Moreover, the itinerant degree of freedom for 5f electrons in PuB
x
(x = 1, 2, 12) is tuned by hybridization strength between 5f states and conduction bands, which is affected by atomic distance in plutonium borides. Lastly, 5f electronic correlations encoded in the electron self-energy functions demonstrate moderate 5f electronic correlations in PuB6 and orbital selective 5f electronic correlations in PuB
x
(x = 1, 2, 12). Consequently, the understanding of electronic structure and related crystal structure stability shall shed light on exploring novel 5f electrons states and ongoing experiment study.
A facile method to synthesize 3D nanosheets of Fe/S doped α-Ni(OH)2 as an electrocatalyst for improved oxygen evolution reaction
Authors: Chu Yuanyuan , Zhang Xiaoxiao , Deng Bohan , Wang Kuixiao , Tan Xiaoyao 
Published: March 2022

Abstract
S-doped Fe/Ni oxide and Fe/Ni hydride oxide catalysts exhibit good oxygen evolution reaction (OER) performance. Nevertheless, the over-doping of S and the agglomeration of active sites still hinder the improvement of the performance of these catalysts. The S/O ratio regulation can optimize the electronic structure effectively so as to improve the OER performance of the catalysts, but few studies have focused on this study. Here, we find a facile room-temperature method to synthesize the unique 3D ultra-thin FeNiOS nanosheets with an adjustable S/O ratio for OER. The FeNiOS-NS catalysts exhibit excellent OER performance with an overpotential of 235 mV at 10 mA cm−2 and a small Tafel slope of 64.2 mV dec−1 in 0.1 M KOH, which originated from the sufficient exposure of the active Fe–Ni component and the optimized electronic structure due to the tunable S/O ratio. This study demonstrates a novel strategy to optimize the OER performance of Ni-based catalysts.
High-performance manganese and nitrogen codoped carbon (Mn–N–C) oxygen reduction electrocatalyst from Mn2+ coordinated sodium alginate
Authors: Kong Ziyan , Wang Huiying , Hou Kun , Guan Lunhui 
Published: March 2022

Abstract
The research on low-cost, high-performance non platinum group metal (PGM) oxygen reduction reaction (ORR) catalysts is of great significance for the rapid promotion of fuel cells’ practical applications. In this work, Mn–N–C catalyst with outstanding activity was prepared through using hydrogel formed by coordination of sodium alginate (SA) and Mn2+ as the precursor. During the preparation process, g-C3N4 was added to improve the surface area enrich the pore structure of catalysts, as well as to function as the nitrogen source. Compare with commercial Pt/C catalyst, the optimum Mn–N–C catalyst possesses extraordinary ORR activity in alkaline electrolytes, with a half-wave potential (E
1/2) of 0.90 V. In addition, the Mn–N–C catalyst also displays exceptional stability in alkaline and acidic electrolytes, much superior to Pt/C catalyst.
Silver-decorated black phosphorus: a synergistic antibacterial strategy
Authors: Deng Fang , Wu Ping , Qian Guowen , Shuai Yang , Zhang Lemin , Peng Shuping , Shuai Cijun , Wang Guoyong 
Published: March 2022

Abstract
Black phosphorus (BP) exhibits great potential as antibacterial materials due to its unique photocatalytic activity. However, the unsatisfactory optical absorption and quick recombination of photoinduced electron–hole pairs restrain its photocatalytic antibacterial performance. In this work, silver nanoparticles (AgNPs) were decorated on BP to construct BP@AgNPs nanohybrids and then introduced into poly-l-lactic acid scaffold. Combining the tunable bandgap of BP and the LSPR effect of AgNPs, BP@AgNPs nanohybrids displayed the broaden visible light absorption. Furthermore, AgNPs acted as electron acceptors could accelerate charge transfer and suppress electron–hole recombination. Therefore, BP@AgNPs nanohybrids achieved synergistically enhanced photocatalytic antibacterial activity under visible light irradiation. Fluorescence probe experiment verified that BP@AgNPs promoted the generation of reactive oxygen species, which could disrupt bacteria membrane, damage DNA and oxide proteins, and finally lead to bacteria apoptosis. As a result, the scaffold possessed strong antibacterial efficiency with a bactericidal rate of 97% under light irradiation. Moreover, the scaffold also exhibited good cytocompatibility. This work highlighted a new strategy to develop photocatalytic antibacterial scaffold for bone implant application.
Thermal transport of bilayer graphene: a homogeneous nonequilibrium molecular dynamics study
Authors: Feng Hao , Zhang Kai , Wang Xin , Zhang Guiqing , Guo Xiaoyong 
Published: March 2022

Abstract
In this paper, the thermal transport of bilayer graphene is revisited by the homogeneous nonequilibrium molecular dynamics (HNEMD) method realized in a graphics processing unit based molecular dynamics package, GPUMD. Our simulations are carried out in three-dimensional boxes. An optimized Teroff potential is used to describe C-C covalent bonds, and the inter-layer van der Waals interaction is described by the 12-6 Lennard-Jones potential. Since the HNEMD method is homogeneous without boundary scattering, we obtain more accurate results than previous nonequilibrium molecular dynamics studies. Through intensive simulations, the main findings of the paper are as follows. (1) We find an efficient simulation setting, yielding results which are in good agreement with the experimental data; (2) Although the increase of the system size and the extension of production period has a beneficial effect to obtain more convergent results, these lead to large discrepancy with the experimental data; (3) The thermal conductivity is reduced by the phonon scattering among graphene layers; (4) The spectral decomposition of thermal conductivity shows that the bilayer graphene retains the spectrum of its monolayer counterpart except for the increasing magnitudes; (5) The spectral phonon mean free path of bilayer graphene reveals the presence of a new phonon mode which may have a negative contribution to the thermal conductivity.