bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices
Authors: Quandt Jonas , Garay‐Sarmiento Manuela , Witzdam Lena , Englert Jenny , Rutsch Yannik , Stöcker Cornelia , Obstals Fabian , Grottke Oliver , Rodriguez‐Emmenegger Cesar 
Published: July 2022

AbstractInterfacing blood with any artificial surface instantly triggers the activation of coagulation at the interface, posing a risk of adverse thromboembolic complications. Immediately upon contact, blood proteins adsorb to the surface turning it into an active prothrombogenic and proinflammatory interface promoting the activation of platelets and the coagulation cascade. Here, an interactive hemocompatible nanocoating is designed that synergistically combines antifouling polymer brushes with the activity of an anti‐FXIIa antibody to tackle the two main causes of surface‐induced coagulation. The brushes provide a passive layer rendering the surface stealth and non‐thrombogenic against blood activation. Furthermore, as soon as traces of FXIIa arise, the coating immediately and specifically scavenges it, thus actively switching‐off contact activation right at the beginning. Moreover, a means is developed to translate this coating to a broad range of polymeric surfaces commonly used in medical devices. The coated surfaces prevent protein adsorption and provide a barrier to bacterial colonization while being capable of capturing biologically relevant concentrations of FXIIa. Notably, the coating completely prevents the formation of clots on the surface when exposed to blood. Thus, the interactive anti‐FXIIa nanocoating provides a new avenue to improve the hemocompatibility of medical devices in a safe and efficient manner.
Randomly Textured Absorber for Omnidirectional Light Absorption
Authors: Wu Zuoxu , Xue Wenhua , Liu Yijie , Hou Shuaihang , Mao Jun , Wang Yumei , Liu Xingjun , Zhang Qian , Ren Zhifeng , Cao Feng 
Published: July 2022

AbstractRealizing light manipulation with respect to both frequency and angular selectivity is of great significance for sunlight‐to‐heat conversion, but developing a facile and scalable method to enhance light absorption at oblique incidence remains a major challenge. Here a randomly textured absorber is theoretically designed and experimentally achieved by depositing a Ti‐SiO2 cermet‐based quasi‐optical cavity structure absorber onto a structured stainless‐steel substrate to realize omnidirectional absorption‐enhanced light absorption over a wide incidence‐angle range up to 75°. A strategy is employed of combined chemical etching and sputtering that is suitable for large‐scale production to prepare the randomly textured absorber, which exhibits a near‐complete absorption of 98% at near‐normal incidence. It also shows a remarkable angular absorption of higher than 85% at an oblique incidence angle of 75°, surpassing previously reported absorbers. The absorber's superior angular absorption is ascribed to multiscale scattering on its randomly textured surface and resonance absorption in its quasi‐optical cavity structure. In addition, the randomly textured absorber demonstrates good hydrophobicity, which is beneficial for practical photothermal applications. This appealing strategy highlights a new route for fabricating other omnidirectional absorbers.
A New Biphotochromic Fluorescent Switch Based on Dithienylethene and Triphenylethylene: Synthesis, Crystal Structure, and Optical Waveguide
Authors: Luo Miao , Zhao Juan , Liu Yanyan , Jiang Long , Wang Sheng , Chi Zhenguo 
Published: July 2022

AbstractA novel biphotochromic fluorescent switch molecule N‐2F derived from dithienylethene (DTE) and triphenylethylene (TPE) is reported. Interestingly, different photochromic and fluorescence phenomena of N‐2F are observed in tetrahydrofuran/water mixtures. When fw ≤ 50%, N‐2F shows effective photochromic and fluorescent switch under alternating with 254 and 500 nm light irradiation due to the DTE unit undergoing reversible cyclization and cycloreversion reactions between its open and closed forms. However, when fw ≥ 60%, the strong blue‐green fluorescence of the original solution is almost quenched under 254 nm light irradiation, but becomes red fluorescent emission under 500 nm light irradiation. When further irradiated with 254 nm, the red fluorescent emission disappears, but it reappears upon 500 nm light illumination. The results reveal that DTE and TPE take cyclization and cycloreversion reactions upon alternating with 254 and 500 nm light irradiations, and TPE will take dehydrogenation reaction with further 254 nm irradiation. Moreover, N‐2F can easily obtain long length (about 2 cm) rod single crystal with high fluorescence quantum yield of 68.97%. Impressively, N‐2F shows excellent optical waveguide with very low loss coefficient of 0.171 dB mm−1. Therefore, N‐2F exhibits potential applications in anti‐counterfeiting, multi‐color display, and functional photonic devices.
A 3D Printer in the Lab: Not Only a Toy
Authors: Saggiomo Vittorio 
Published: July 2022

AbstractAlthough 3D printers are becoming more common in households, they are still under‐represented in many laboratories worldwide and regarded as toys rather than as laboratory equipment. This short review wants to change this conservative point of view. This mini‐review focuses on fused deposition modeling printers and what happens after acquiring your first 3D printer. In short, these printers melt plastic filament and deposit it layer by layer to create the final object. They are getting cheaper and easier to use, and nowadays it is not difficult to find good 3D printers for less than €500. At such a price, a 3D printer is one, if not the most, versatile piece of equipment you can have in a laboratory.
Antitrust policy for the 2020s: Some sensible ways forward
Authors: White Lawrence J. 
Published: July 2022

AbstractAntitrust policy in the United States has recently gained an unusual amount of political and media attention—including with regard to the application of antitrust to the agricultural sector. There are critics who have argued that a major overhaul of antitrust policy is needed. This paper argues that instead there are some important but more modest changes that could go a long way toward significantly strengthening the role that antitrust can play in keeping the US economy competitive, vibrant, and innovative.
Additively manufactured cryogenic microchannel distillation device for air separation
Authors: Bottenus Danny R. , Humble Paul H. , Burnett Russell , Harper Warren , Veldman Tim , Powell Michael R. , Barclay John A. , Ely James 
Published: July 2022

AbstractThe efficiency of air separation is tested using three different small‐scale cryogenic distillation columns. The performance of a random packed column is compared to the performance of two microchannel distillation (MCD) columns that use thin wicking structures and gas flow channels to achieve process intensification. The MCD columns tested include a plate‐type layered column and an additively manufactured porous honeycomb (AMPH) column. For columns with 25.4 cm of active height and run under similar conditions, the packed, plate‐type layering, and AMPH columns achieved approximate height equivalent of a theoretical plate (HETP) values of 5.5, 3.7, and 3.2 cm for nitrogen, and 5.9, 4.9, and 3.3 cm for argon. The AMPH column can produce up to 0.4 SLM of more than 90% purity oxygen with 12 W of cooling lift. These results demonstrate the feasibility of using additive manufacturing to construct MCD devices and pave a way for constructing novel MCD designs.
Mechanistic insights and implications of FOXO‐SNAI interplay
Authors: Guo Xiaowei , Wu Chenxi , Pan Yu , Zhu Xiaojie , Peng Kai , Ma Xianjue , Xue Lei 
Published: July 2022

AbstractAutophagy promotes both health and disease, depending on tissue types and genetic contexts, yet the regulatory mechanism remain incompletely understood. Our recent publication has uncovered a coherent FOXO‐SNAI feed‐forward loop in autophagy, which is evolutionarily conserved from Drosophila to human. In addition, it's revealed that DNA binding plays a critical role in intracellular localization of nucleocytoplasmic shuttling proteins. Based on these findings, herein we further integrate mechanistic insights of FOXO‐SNAI regulatory interplay in autophagy and unravel the potential link of FOXO‐induced autophagy with SNAI in diseases. Besides, the generality of DNA‐retention mechanism on transcription factor nuclear localization is illustrated with wide‐ranging discussion, and more functions potentially regulated by FOXO‐SNAI feedforward loop are provided. Elucidation of these unsolved paradigms will expand the understanding of FOXO‐SNAI interplay and facilitate the development of new therapeutics targeting FOXO‐SNAI axis in diseases.
What Wilhelm Ostwald meant by “Autokatalyse” and its significance to origins‐of‐life research
Authors: Peng Zhen , Paschek Klaus , Xavier Joana C. 
Published: July 2022

AbstractA closer look at Wilhelm Ostwald's articles that originally proposed the concept of autocatalysis reveals that he accepted reactants, not just products, as potential autocatalysts. Therefore, that a process is catalyzed by some of its products, which is the common definition of autocatalysis, is only a proper subset of what Ostwald meant by “Autokatalyse.” As a result, it is necessary to reconsider the definition of autocatalysis, which is especially important for origins‐of‐life research because autocatalysis provides an abiotic mechanism that yields reproduction‐like dynamics. Here, we translate and briefly review the two key publications on autocatalysis by Ostwald to revive his understanding of autocatalysis, and we introduce the concepts of recessive and expansive autocatalysis. Then we discuss the twofold significance of such a revival: first, facilitating the search for candidate processes underlying the origins of life, and second, updating our view of autocatalysis in complex reaction networks and metabolism.
Interactional, functional, and biological properties of lactone sophorolipid (LSL) and collagen oligopeptides (COP) in aqueous solution
Authors: Chen Yanrong , Hao Shengyu , Xuan Hong Zhuan , Li Mingyuan , Kong Jing , Zhang Qian , Liu Jie 
Published: July 2022

AbstractFor the mixed aqueous solution of LSL and COP, the interaction mode and mechanism have been comprehensively studied using multispectral methods including fluorescence spectrum, ultraviolet–visible (UV–vis )adsorption spectra, and circular dichroism (CD) spectra. The surface activity, particle size, foaming, emulsifying, viscosity, and antibacterial properties were evaluated in detail using a surface tension measurement (ST), dynamic light scattering (DLS), oscillometric method, spectrophotometer, Ubbelohde viscometer, and zone of inhibition separately. Compared with the single LSL or COP aqueous solution, the mixed system shows different performance optimizations in different aspects. The surface activity and foaming properties are mainly attributed to LSL, and the viscosity is attributed to COP. Fluorescence spectroscopy results show using LSL addition that the fluorescence distribution of COP has significant changes and a static quenching mechanism was proved. The results of UV–vis and CD spectra also show the changing conformation of COP using LSL addition. Data on thermodynamic parameters demonstrated that the combination of LSL and COP gives a spontaneous exothermic process and is an enthalpy‐driven process. The interaction mechanism between LSL and COP is very helpful for the application and development of the mixed mild biosurfactant–protein system used in the cosmetic and food industries.
Structural hybridization for inhibitors of the interaction between NRF2 and Keap1
Authors: Lee Dong Heun , Seo Seon Hee , Gotina Lizaveta , Pae Ae Nim , Lim Sang Min 
Published: July 2022

AbstractNRF2 is considered as a master regulator of cellular defense system under stressed conditions such as oxidative stress. In physiological conditions, NRF2 forms a complex with Keap1‐Cul3 in the cytoplasm and undergoes ubiquitination and subsequent degradation. Under stressed conditions, the interaction between NRF2 and Keap1 is perturbed leading to NRF2 stabilization and migration to the nucleus where NRF2 activates genes accounting for antioxidative activities. Thus, small molecules that can disturb the interaction between NRF2 and Keap1 has been considered as promising for a variety of diseases. Herein, we report development of new, potent inhibitors of the interaction between NRF2 and Keap1 by deconvoluting previous inhibitors followed by structural hybridization. The most potent inhibitor identified by our FP assay showed IC50 of 0.6 μM. We believe that our compounds will help to expand structural diversity of NRF2–Keap1 interaction inhibitors contributing to further development of promising candidates for various diseases.
Application progress of immobilized biomembrane in the discovery of active compounds of natural products
Authors: Liu Sha , Sang Zhenqi , Qin Lupin , Gong Wan , Zhao Luying , Zhang Qiaoyan , Zhao Qiming 
Published: July 2022

AbstractNatural products (NP) are an important source of bioactive compounds. Considering their complex matrix effects, the development of suitable methodologies for the quick identification and analysis of active substances in NPs played a significant role in controlling their quality and discovering new drugs. In recent years, the technology of immobilized biomembrane has attracted increasing attention, due to its advantages such as multitarget efficiency, accuracy, and/or time‐saving compared with traditional activity‐guided separation and ligand fishing methods. This article provides a systematic review of the latest advances in screening technologies based on biomembrane in the field of NPs. It includes detailed discussions on these technologies, including cell membrane chromatography, artificial membrane chromatography, cell membrane fishing, living cell fishing methods, and their applications in screening various active molecules from NPs. Their limitations and future development prospects are further discussed.
Unique liquid chromatography technique for the determination of mirabegron in the presence of polymers; robustness by Design Expert in the light of Quality by Design
Authors: Konduru Naresh , Kowtharapu Leela Prasad , Gundla Rambabu 
Published: July 2022

AbstractThe current study is designed to estimate mirabegron in the presence of high molecular weight polymers using a unique liquid chromatography method and sample preparation technique. The proposed method is significant because of the many analytical issues faced during the development studies. Based on the experimental results, we finally achieved the stability‐indicating power of the method. The adequately prepared mobile phase was in the ratio of pH 2.0 buffer and acetonitrile (80:20) v/v, and the buffer pH 2.0 was prepared as follows: 8.7 ml of perchloric acid, 2 ml of triethylamine and 3.0 g sodium hydroxide into 1 L of water mixed well. The system suitability parameters were achieved using a Waters X‐Bridge C18 (4.6 × 150 mm, 3.5 μm) column and mobile phase. The optimized chromatographic conditions included a column temperature of 45°C, a flow rate of 1.0 ml min−1; an injection volume of 5 μl, UV 247 nm, and 15 min runtime. The method was validated and transferred to quality control as per International Conference on Harmonization Q2(R1) and the Chinese Pharmacopoeia 2020 edition <9101> and <9100>. The recovery and linearity results were obtained between 99.0 and 101.0%; the value of r2 was 0.9998. The method robustness study was established by utilizing the Design of Experiments part of the Quality by Design concept. The method’s stability‐indicating nature was proved by a forced degradation study; all of the conditions for analyte peak purity were passed, and mass balance was achieved. The method was used to determine mirabegron assay, as well as content uniformity, blend uniformity and cleaning samples. It is a user‐friendly and cost‐effective method.
Plant‐based dietary patterns and cognitive function: A prospective cohort analysis of elderly individuals in China (2008–2018)
Authors: Zhu Anna , Yuan Changzheng , Pretty Jules , Ji John S. 
Published: July 2022

AbstractIntroductionPlant‐based diets confer health benefits, especially on the prevention of noncommunicable diseases. The relationship between plant‐based dietary patterns on cognitive function as a neurological outcome needs more evidence. We aimed to assess the associations between plant‐based dietary patterns and cognitive function among Chinese older adults.MethodsWe used four waves (2008–2018) of the Chinese Longitudinal Healthy Longevity Survey. We included 6136 participants aged 65 years and older with normal cognition at baseline. We constructed an overall plant‐based diet index (PDI), healthful plant‐based diet index (hPDI), and unhealthful plant‐based diet index (uPDI) from questionnaires. We used the Mini‐Mental State Examination (MMSE) to assess cognitive function. We used the multivariable‐adjusted generalized estimating equation to explore the corresponding associations.ResultsThe multivariable‐adjusted models showed inverse associations between plant‐based dietary patterns and cognitive function. The highest quartiles of PDI and hPDI were associated with a 55% (odds ratio [OR] = 0.45, 95% CI: 0.39, 0.52) decrease and a 39% (OR = 0.61, 95% CI: 0.54, 0.70) decrease in the odds of cognitive impairment (MMSE < 24), compared with the lowest quartile. In contrast, the highest quartile of uPDI was associated with an increased risk (OR = 2.03, 95% CI: 1.79, 2.31) of cognitive impairment. We did not observe pronounced differences by selected socioeconomic status, physical activity, residential greenness, and APOE ε4 status.ConclusionsOur findings suggested that adherence to healthy plant‐based dietary patterns was associated with lower risks of cognitive impairment among older adults, and unhealthy plant‐based dietary patterns were related to higher risks of cognitive impairment.
REverSe TRanscrIptase chain termination (RESTRICT) for selective measurement of nucleotide analogs used in HIV care and prevention
Authors: Olanrewaju Ayokunle O. , Sullivan Benjamin P. , Gim Alicia H. , Craig Cosette A. , Sevenler Derin , Bender Andrew T. , Drain Paul K. , Posner Jonathan D. 
Published: July 2022

AbstractSufficient drug concentrations are required for efficacy of antiretroviral drugs used in HIV care and prevention. Measurement of nucleotide analogs, included in most HIV medication regimens, enables monitoring of short‐ and long‐term adherence and the risk of treatment failure. The REverSe TRanscrIptase Chain Termination (RESTRICT) assay rapidly infers the concentration of intracellular nucleotide analogs based on the inhibition of DNA synthesis by HIV reverse transcriptase enzyme. Here, we introduce a probabilistic model for RESTRICT and demonstrate selective measurement of multiple nucleotide analogs using DNA templates designed according to the chemical structure of each drug. We measure clinically relevant concentrations of tenofovir diphosphate, emtricitabine triphosphate, lamivudine triphosphate, and azidothymidine triphosphate with agreement between experiment and theory. RESTRICT represents a new class of activity‐based assays for therapeutic drug monitoring in HIV care and could be extended to other diseases treated with nucleotide analogs.
Study on the Chemical Profile of Chrysanthemum (Chrysanthemum morifolium) and the Evaluation of the Similarities and Differences between Different Cultivars
Authors: Ouyang Huizi , Fan Yuqi , Wei Shujie , Chang Yanxu , He Jun 
Published: July 2022

AbstractChrysanthemum originates in China and has been cultivated for tea and food utilizations over two thousand years. According to differences in origin and processing methods, Chrysanthemum morifolium Ramat. can be categorized into many cultivars. This study aims to investigate the chemical components in chrysanthemum and clarify similarities and differences between different chrysanthemum varieties. A total of 55 non‐volatile components and 66 volatile components in chrysanthemum were identified by ultra‐high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry (UPLC‐Q‐TOF‐MS/MS) and gas chromatography‐mass spectrometry (GC/MS) methods, respectively. A rapid UPLC–MS/MS method was developed and validated for the simultaneous determination of 13 active components in 30 batches chrysanthemum samples of ten different cultivars. Multivariate statistical techniques were applied to analyze the samples. The result indicated that Boju, Huaiju and Chuju were more similar in terms of the ingredient content and Qiju, Jinsihuangju, Huangju, Hangju, Gongju, Fubaiju, Baiju have a high degree of similarity. Furthermore, isochlorogenic acid C, luteolin, apigenin‐7‐glucoside, chlorogenic acid, apigenin and cryptochlorogenic acid plays an important role in distinguishing different varieties of chrysanthemum. The established strategy explains the similarities and differences between different varieties of chrysanthemums to some extent, and provides certain reference value for the choice of chrysanthemums for eating or medicinal purposes in daily life.
Plasma cell leukemia presenting as spontaneous tumor lysis syndrome with hypercalcemia
Authors: Shafie Mahan , Issaiy Mahbod , Barkhori Mahdi , Parsa Samaneh 
Published: July 2022

AbstractTumor lysis syndrome (TLS) is an oncologic emergency in which tumor cells undergo lysis either spontaneously or due to the initiation of cancer therapy typically presenting with hypocalcemia. We described a 62‐year‐old male patient with spontaneous TLS and hypercalcemia without a known malignancy, who is later discovered to have plasma cell leukemia.
Subdural empyema due to mixed infections successfully treated medically: A case report with review literature
Authors: Meshref Mostafa , Nourelden Anas Zakarya , Elshanbary Alaa Ahmed , AbdelQadir Yossef Hassan , Zaazouee Mohamed Sayed , Ragab Khaled Mohamed , Ahmed Eman Mohammed Sharif , Swed Sarya 
Published: July 2022

AbstractSubdural empyema is a rare intracranial infection with an accumulation of purulent material between the dura and arachnoid matter. We report a case of 17 years old presented with an altered conscious level. CSF analysis showed increased WBCs. His situation has improved after treating by acyclovir, ceftriaxone, vancomycin, and dexamethasone.
First Investigation of Nonlinear Optical Oxychalcogenide with Three‐Dimensional Anionic Framework and Special Windmill‐Like Functional Motifs†
Authors: Li Jia‐Nuo , Li Xiao‐Hui , Xu Ying‐Xuan , Liu Wenlong , Guo Sheng‐Ping 
Published: July 2022

Comprehensive SummaryOxychalcogenides have been drawn much attention to be explored as nonlinear optical (NLO) materials in recent years. To date, all the NLO oxychalcogenides crystallize in low dimensional structures. Herein, a new oxysulfide K2Ba0.5Ga9O2S13 was obtained via three‐dimensional (3D) {[Ga9O2S13]3–}∞ polyanionic framework. As the first oxychalcogenide with 3D NLO‐acitve polyanionic framework, K2Ba0.5Ga9O2S13 has a wide band gap of 3.72 eV, and exhibits a high laser‐induced damage threshold (LIDT, 17 × AgGaS2). It presents moderate phase‐matchable NLO response of 0.5 × AgGaS2 at 2.1 μm and 2 × KH2PO4 at 1.064 μm. The theoretical calculation results indicate that the NLO response is mainly contributed from [Ga(2)S4] unit‐built [Ga(2)3S10] windmill‐like motif. This work may stimulate the exploration of more NLO oxychalcogenides with balanced performances.