bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 Positivity in Early Infancy: A National Cohort From Saudi Arabia
Authors: Shaiba Lana A. , Hadid Adnan , Altirkawi Khalid , Alnamnakani Mahdi A. , Almutayliq Abdulaziz A. , Alharbi Areen T. , Hijazi Asmar M. , AlMoosa Khalid M. , AlSaud Nora F. , Murshid Rozan E. , AlMuhanna Wejdan S. , Aldawsari Nasser A. , Bin Hadyan Maryam F. , Almaghrabi Rana , Alsofayan Yousef M. , Alahmari Ahmed A. , Almuzaini Yasir S. , Alamri Fahad A. , Khan Anas A. , Shah Prakesh S. 
Published: March 2022

BackgroundData on SARS-CoV-2 in infants ≤ 90 days are limited with conflicting reports regarding its presentation and outcomes.MethodsWe conducted an ambispective cohort study using prospectively collected Health Electronic Surveillance Network Database by the Ministry of Health, Saudi Arabia. Infants of ≤ 90 days of age who had a positive RT-PCR test for SARS-CoV-2 virus were included. Patients were divided in Early neonatal (0–6 days), late neonatal (7–27 days), and post- neonatal (28–90 days) groups and were compared for clinical characteristics and outcomes by contacting parents and collecting information retrospectively.ResultsOf 1,793 infants, 898 infants were included for analysis. Most infants in the early neonatal group had no features of infection (tested based on maternal positivity), whereas most infants in the late and post- neonatal groups were tested because of clinical features of infection. Fever and respiratory signs were the most common presenting feature in the late and post-neonatal groups. Hospitalization was higher in the early neonatal group (80%), compared to the two other groups. The overall mortality in the cohort was 1.6%.ConclusionSARS-CoV-2 infection in infants ≤ 90 days might not be as rare as previously reported. The clinical presentation varies based on age at positive RT-PCR result.
Selected Behaviors and Addiction Risk Among Users of Urban Multimedia Games
Authors: Grajek Mateusz , Olszewski Łukasz , Krupa-Kotara Karolina , Białek-Dratwa Agnieszka , Sas-Nowosielski Krzysztof 
Published: March 2022

IntroductionThe rapid development of technology has led to the transfer of entertainment to the virtual world. Many games and multimedia applications use the so-called augmented reality. With the development of a new technological branch, a new health problem has emerged, which is infoholic addiction, attracting people with the specific functionality that is cyberspace and the virtual world.ObjectiveThe study aimed to assess health behaviors and the risk of addiction among users of urban multimedia games. Research methodology. The study was conducted among players 1,134 of urban multimedia games—Pokemon GO, in the period March–June 2021. A 990 correctly completed questionnaires were included in the final analyses. The author’s questionnaire was used in the study, which included two standardized measurement scales in the Polish abbreviated version: a questionnaire of emotions and sensations associated with electronic entertainment and a questionnaire on addiction to electronic forms of entertainment. Statistica 13.0 program was used for statistical processing of the data. The probability level was p &lt; 0.05.ResultsThe profile of the gamer was identified as male, aged 18–30 years, with secondary education (more rarely higher), not in a relationship, living in a city of more than 100 thousand inhabitants—60.1% of gamers met these criteria. Respondents played urban multimedia games daily (84.7%). About 26.3% of respondents played this type of game 2–3 h a day. In terms of physical fitness, 64.3% of respondents felt that physical fitness had improved as a result of playing multimedia urban games. In terms of mental condition, most of the respondents said that nothing had changed (55.3%). It was observed that 72.3% of respondents had some risk of addiction to urban multimedia games.ConclusionUsers of urban multimedia games were usually adult men living in big cities. It was also shown that the defined profile of the player was characterized by a higher risk of addiction to electronic forms of entertainment. It was observed that the respondents most often played urban multimedia games every day in a maximum of two-hour sessions. Based on the tools used, it can be concluded that the study group was characterized by a certain risk of addiction to urban multimedia games.
Associations of Face-to-Face and Instant Messaging Family Communication and Their Contents With Family Wellbeing and Personal Happiness Amidst the COVID-19 Pandemic
Authors: Gong Wei Jie , Sit Shirley Man Man , Wong Bonny Yee Man , Wu Socrates Yong Da , Lai Agnes Yuen Kwan , Ho Sai Yin , Wang Man Ping , Lam Tai Hing 
Published: March 2022

BackgroundBoth face-to-face and instant messaging (IM) communication are important for families, but face-to-face communication has reduced amidst the COVID-19 pandemic. We examined the use and contents of both communication methods amidst the pandemic, their associations with family wellbeing and personal happiness, and the mediation effects of communication quality in Hong Kong Chinese adults.MethodsThis population-based online survey enrolled 4,921 respondents in May 2020, who reported (i) any face-to-face or IM family communication when the pandemic was severe; (ii) communication contents being classified as neutral, positive, supportive, and negative; and (iii) communication quality, family wellbeing and personal happiness (score 0–10). Associations of family wellbeing and personal happiness with communication methods and contents (no communication excluded) were examined using linear regressions (β), adjusting for each other, sex, age, socioeconomic status, and the number of cohabitants. Mediating effects of communication quality on these associations were examined. Prevalence estimates were weighted by sex, age, and education of the general population. Interactions of methods and contents were examined.ResultsOf 4,891 included respondents (female: 52.9%, 45–54 years: 37.7%, ≥65 years: 21.3%), 7.1% reported no communication, 12.7% face-to-face communication only, 26.7% IM only, and 53.4% both methods. More males and those at younger ages, had lower socioeconomic status, or fewer cohabitants showed no family communication or face-to-face only. More respondents reported neutral (83.1–99.3%) than positive (42.1–62.2%), supportive (37.5–54.8%), and negative (10.9–34.5%) contents despite communication methods. Communication quality was higher with both methods than IM only, face-to-face only, and no communication (scores: 6.7 vs. 4.5–6.6, all P ≤ 0.02). Better family wellbeing and personal happiness were associated with using IM only (adjusted βs: 0.37 and 0.48) and both methods (0.37 and 0.42) than face-to-face only, and positive (0.62 and 0.74) or supportive (0.45 and 0.46) contents (all P ≤ 0.001). Communication quality mediated 35.2–93.5% of these associations. Stronger associations between positive contents and family wellbeing showed in both methods and face-to-face only than IM only (P for interaction = 0.006).ConclusionsWe have first shown that, amidst the COVID-19 pandemic, family IM communication and positive and supportive contents may promote family wellbeing and personal happiness. People with no family communication may need assistance.
Assessment of Knowledge, Attitude, and Practice Regarding Diabetic Retinopathy in an Urban Population in Northeast China
Authors: Qi Jin-Yan , Zhai Gang , Wang Yu , Liang Yuan-Bo , Li Dong , Wen Liang , Zang Dong-Xiao , Feng Ke-Mi , Zang Bo , Xie Cong 
Published: March 2022

ObjectiveThis study aimed to assess the knowledge, attitude, and practice (KAP) of diabetic subjects with diabetic retinopathy (DR) and those without DR (NDR) in an urban community in Northeast China, as well as their risk factors in subjects with DR and NDR.MethodsA community-based survey involving 1,662 subjects was conducted in Fushun, China, between July 2012 and May 2013. The subjects included diabetics with DR (n = 783) and those NDR (n = 879), and questionnaires were completed to collect information about their sociodemographic and healthcare characteristics. A Chi-square test and multiple logistic analyses were performed to analyze the data.ResultsAmong the DR group, 21.88% had a good knowledge of DR, 94.15% had a positive attitude, and 68.07% followed good practice, whereas 20.98% of the NDR group had a good knowledge of DR, 94.18% had a positive attitude, and 66.92% followed good practice. There was no significant difference in the KAP of the two groups of subjects. In the NDR group, a good level of knowledge was associated with a high-level of education (OR = 0.1, 0.2; p &lt; 0.05), a good attitude was associated with retirement (OR = 0.2; p &lt; 0.05), and good practice was associated with being female, having a high-level of education, and the type of treatment (OR = 0.5, 0.4, 2.3, 3.1; p &lt; 0.05). In the DR group, good practice was associated with older age and retirement (OR = 0.6, 0.4; p &lt; 0.05).ConclusionsThere was no significant difference between the DR and NDR subjects in the overall levels of KAP, but both groups showed a poor level of knowledge. Age, gender, education, occupation, and type of treatment were the main factors associated with the KAP scores, more risk factors in the NDR group than in the DR group. There is an urgent need for coordinated educational campaigns with a prioritized focus on the northeast region of China, especially NDR group.
Comparison of Neuroendoscopic and Microscopic Surgery for Unilateral Hemilaminectomy: Experience of a Single Institution
Authors: Zeng Wei , Jiang Haixiao , He Shiwei , Zhang Yukun , Yu Bo , Wang Hui , Wang Cunzu 
Published: March 2022

ObjectiveThis study was designed to compare the safety and efficacy of unilateral hemilaminectomy conducted under complete neuroendoscopic visualization (UHNV) relative to unilateral hemilaminectomy under total microscopic visualization (UHMV) for the treatment of patients diagnosed with intraspinal tumors.MethodsIn total, 41 patients undergoing intraspinal tumor resection at Northern Jiangsu People's Hospital were included in this study, including 20 and 21 patients in the UHNV and UHMV groups, respectively. Intraoperative parameters including incision length, operative duration, number of vertebral laminae removed and intraoperative blood loss, as well as indicators of curative efficacy such as total tumor resection rates and postoperative symptom improvement rates, and safety indicators including complication rates, recurrence rates, spinal deformity rates, spinal instability incidence, and length of stay (LOS), were compared between the two groups.ResultsIn contrast to the UHMV group, patients in the UHNV group had a significantly shorter incision length and decreased intraoperative blood loss (P &lt; 0.05), while the operative duration (P &gt; 0.05) showed no statistical difference. Although the postoperative improvement and total tumor resection rates were enhanced, the difference was not statistically significant (P &gt; 0.05). In comparison, the bedridden time and length of stay (LOS) were significantly shortened (P &lt; 0.05) in the UHNV group. However, there were no significant differences in recurrence, incidence of complications, spinal deformity, and spinal instability (P &gt; 0.05).ConclusionCollectively, our findings indicate that UHNV is not inferior to the UHMV approach. Moreover, due to its safe and minimally invasive nature, UHNV represents a promising alternative to UHMV as a treatment for patients with intradural extramedullary tumors.
PSYCHOLOGICAL AND PEDAGOGICAL CONDITIONS FOR PRESCHOOL CHILDREN’S CREATIVITY FORMATION
Authors: PASICHNICHENKO A. 
Published: March 2022

The article contains a substantiation of the urgency of the issue of preschool children’s creativity formation. A number of approaches to defining the category ‘creativity,’ its components, and parameters for assessing creativity are analyzed. It is noted that modern science contains different approaches to creativity analysis and defines it as the ability to produce new, original ideas and offer non-standard solutions. It is emphasized that the category ‘creativity’ is used in some scientific studies as a synonym for ‘creation,’ but has its specific features. Creative activity is the foundation, a prerequisite for the individual’s creative potential development. It is indicated that preschool age is a sensitive period for creative component development. Creativity is defined as one of a preschool child’s key personality traits, which characterizes the child’s active position, readiness for spontaneous decisions, curiosity, ability to verbally comment on the process and result of their activities, stable motivation, developed imagination, and ability to create creative images, which are original, varied and mobile.
The article identifies the main psychological and pedagogical conditions for preschool children’s creativity formation. In particular, it emphasizes the need for a favorable psychological atmosphere, which provides a friendly attentive attitude on the part of the adult, support, praise, avoidance of inadequate criticism. Emphasis is placed on the need to create a developmental environment, all elements of which must contain the necessary incentives for creative potential, novelty, problems, designed to ensure and stimulate free choice and change of the child’s activities, to create problem situations relevant for their and available for their development. It is noted that essential conditions for creativity formation are the use of various means (experimentation, fairy tale) and the involvement of the child in various activities (play, art). Attention is focused on the fact that one of the factors of successful preschool children’s creativity formation is an adult. They should offer a personal example of a creative approach to non-standard problem solving, provide a positive example of creative behavior and create conditions for its imitation.
Effect оf Excipients оn the Physicochemical Properties of Phytosyrup
Authors: Бондаренко А.С. , Гладух Е.В. 
Published: March 2022

При разработке лекарственных препаратов особая роль отводится вопросам стабильности, биодоступности, приемлемым органолептическим свойствам и созданию комфортных условий приема. Все эти вопросы решаются путем введения в лекарственные формы вспомогательных веществ, которые оказывают влияние на их физико-химические свойства. Цель исследования. Определение физико-химических свойств разработанного фитосиропа и изучение влияния на них вспомогательных веществ. Материалы и методы. В соответствии с требованиями Государственной фармакопеи Украины нами были исследованы физико-химических показатели: описание, вязкость, относительная плотность, значение pH. Результаты. В ходе исследований была установлена зависимость физико-химических свойств разработанного сиропа от концентраций таких вспомогательных веществ, как сорбит и пропиленгликоль. В результате микробиологических исследований было обосновано использование в качестве консервантов сочетания нипагина с нипазолом.
In the development of drugs, a special role is given to stability, bioavailability, acceptable organoleptic properties and the creation of comfortable reception conditions. All these issues are solved by introducing into the dosage form auxiliary substances that affect their physicochemical properties. Purpose. To determine the physicochemical properties of the developed phytosyrup and study the influence of excipients on them. Materials and methods. Methods of physical and chemical research in accordance with the requirements of the State Pharmacopoeia of Ukraine have been used: description, viscosity, relative density, pH value. Results. In the course of the research, the dependence of the physicochemical properties of the developed syrup on the concentrations of such auxiliary substances as sorbitol and propylene glycol was established. As a result of microbiological studies, the combination of nipagin with nipazole as preservatives was justified.
Main Aspects of Diagnosis and Treatment of Atopic Dermatitis
Authors: Артишевский С.Н. 
Published: March 2022

В представленной работе изложены общие вопросы этиологии и патогенеза формирования атопического дерматита, его эпидемиологические особенности. Автор подробно изложил главные и дополнительные диагностические критерии. Рассмотрены особенности клинической картины заболевания в зависимости от возрастной периодизации, характера течения заболевания и распространенности процесса. Дана оценка тяжести по международной системе SCORAD, которая лежит в основе ступенчатого подхода к лечению атопического дерматита у детей и взрослых. Изложены подходы к лечению, включая немедикаментозные методы и базисную терапию эмолиентами, направленную на восстановление водно-липидного барьера кожи, восстановление регенерации кожного покрова, а также особенности терапии осложненного атопического дерматита бактериальной, грибковой инфекцией. Медикаментозная терапия представлена топическими и системными лекарственными средствами. Наружная терапия состоит из топических кортикостероидных препаратов и ингибиторов кальциневрина. Дана классификация наружных средств, показания к их применению, побочные эффекты, а также тактика назначения в зависимости от клинического состояния. Лекарственные препараты системного действия представлены антигистаминными, системными кортикостероидами, циклоспорином. Подробно изложены показания для каждой группы препаратов, особенности тактики их назначения и побочные эффекты, которые они вызывают.
The paper presents general questions of the etiology and pathogenesis of atopic dermatitis, its epidemiological features. The author described in detail the main and additional diagnostic criteria. The features of the clinical picture of the disease depending on the age periodization, the nature of the course of the disease and the prevalence of the process are considered. The severity assessment is based on the international SCORAD system, which is the basis of a step-by-step approach for the treatment of atopic dermatitis in children and adults. Treatment approaches are described, including non-drug methods and basic therapy with patients aimed at restoring the water-lipid barrier of the skin, restoring and regenerating the skin, as well as features of the treatment of complicated atopic dermatitis with bacterial and fungal infection. Drug therapy is represented by topical and systemic medications. External therapy consists of topical corticosteroid medications and calcineurin inhibitors. The classification of external agents, indications for their use, side effects, and tactics of appointment depending on the clinical condition are given. Systemic medications are represented by antihistamines, systemic corticosteroids, and cyclosporine. The indications for each group of drugs, the specific tactics of their administration and the side effects they cause are described in detail.
Plasma Calcium and Phosphorus Levels and Cardiovascular Disease Risks in Egyptian Type 2 Diabetic Patients
Authors: Al-Okbi Sahar , Sabry Seham , Al-Siedy Enas S. K. , Elsayed Shaimaa 
Published: March 2022

Background: Cardiovascular complication of diabetes is considered an important issue that needs deep investigations. The levels of plasma calcium (Ca) and phosphorus (P) have been implicated as having an association to cardiovascular diseases.
AIM: The objective of the present research was to study the plasma levels of both Ca and P and their association to the atherogenic ratio; total cholesterol: high density lipoprotein-cholesterol and the plasma albumin in male and female patients with type 2-diabetes. The interrelation between anthropometric parameters represented by body mass index (BMI), waist circumference and waist/hip ratio with Ca and P were studied. Also, the association between plasma Ca and P with their dietary intake were investigated.
Subjects and METODS: Thirty-one type 2-diabetic male and female patients participated in the study, in addition of ten healthy subjects. Biochemical parameters, anthropometric measurements and nutrients′ intake were assessed. Biochemical parameters include plasma Ca, P, lipid profile, albumin, liver function tests and creatinine.
RESULTS: Plasma Ca levels of female patients of BMI> 30 kg/m2 demonstrated significant increase compared to the control group. All male and female patients showed significant increase in plasma P compared to the control group. Glycosylated hemoglobin of male and females showed significant high values compared to the control group except for diabetic male of BMI>30 kg/m2 that showed insignificant increase. No significant changes in plasma TG and LDL-C levels were noticed compared to the control. Plasma TC of patients showed significant high levels compared to the control group. The levels of HDL-C of patients were significantly lower than that of the control. The ratios of TC/HDL-C diabetic patients either male or female and whatever their BMI were significantly higher than that of the control. No significant changes in plasma activities of ALT and AST and bilirubin levels were observed among the different groups including the control. Plasma albumin levels demonstrated significant reduction compared to the control group whatever their sexes or BMI. Plasma creatinine levels of the different diabetic groups showed insignificant change from the control group except for the male group of BMI<30 kg/m2 that showed significant elevation. In male, plasma Ca showed significant negative correlation with albumin and positive correlation with creatinine and dietary vitamin D. In female, a significant positive correlation was noticed between plasma and dietary P while a negative correlation was observed between plasma Ca and dietary iron.
CONCLUSION: Elevated of plasma P together with reduced plasma albumin and elevated TC/HDL-C may reflect an association of plasma P to CVD in male and female diabetic subjects while high plasma Ca might predict CVD in only female diabetic patients of BMI > 30 kg/m2.
Malnutrition as Risk Factor for Febrile Neutropenia in Children with Acute Lymphoblastic Leukemia
Authors: Hanzelina Hanzelina , Widnyana A. A. N. K. P. , Windiani I Gusti Ayu Trisna , Karyana I Putu Gede , Ariawati Ni Ketut , Mahalini Dewi Sutriani 
Published: March 2022

BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Febrile neutropenia is one of medical emergencies in ALL patients. One of the risk factors that associate with febrile neutropenia is malnutrition. Malnutrition reduce the body’s immunity that increase incidence of infection.
AIM: aimed to prove malnutrition as risk factor in children with ALL who had febrile neutropenia
METHOD: This is case-control study with samples a hundred children aged 1 month to 18 years old with ALL at Sanglah Hospital Denpasar between 2015 - 2021. Subjects were grouped into two, those with febrile neutropenia and without febrile neutropenia. The relationship between malnutrition and febrile neutropenia was analyzed by using chi-square bivariate analysis test.

RESULTS: A hundred subjects were devided into two groups with 50 subjects each group. Bivariate analysis showed significant association between malnutrition and febrile neutropenia (OR 4.53; 95%CI 1.95 - 10.51; p-value <0.001).
CONCLUSION: Malnutrition as risk factor for febrile neutropenia in children with ALL.