bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validated transport conditions maintain the quality of washed red blood cells
Authors: Baker Steven Andrew , Wong Lisa Kanata , Wieland Rebekah , Bulterys Philip , Allard Libby , Nguyen Lang , Quach Thinh , Nguyen AnhThu , Chaesuh Eunkyong , Cheng Phil , Bowen Raffick , Virk Mrigender 
Published: August 2022

AbstractBackgroundWashing red blood cell (RBC) units prior to transfusion is indicated for certain patients. In the United States, units stored at 1°C–6°C or transported at 1°C–10°C are available for issue up to 24 h, if not used immediately. The washing procedure commonly utilizes room temperature saline resulting in units starting out above the allowed temperature range. This leads to wastage if units are issued and returned too quickly before having a chance to equilibrate in a transport cooler.Study Design and MethodsHere we performed an experimental study of washed RBC quality comparing “ideal” storage conditions in a blood bank refrigerator to a “real‐world” simulation of unit transport, including holding in a transport cooler. Twelve RBC units were washed and allocated evenly into either condition.ResultsMeasurements at 0, 1, 3, 6, 12, and 24 h post‐washing revealed that placement in a transport cooler was associated with higher unit temperature prior to 12 h (p = .013) with a maximum difference of 9.3°C. Despite this difference, several measures of unit quality including extracellular potassium, pH, lactate, and free hemoglobin were indistinguishable between conditions (p = .382, .224, .286, .691, respectively). We selected half of the tested units from our irradiated inventory and confirmed increased potassium leak (p < .001) and accumulation of free hemoglobin (p = .012) in irradiated units.DiscussionWashed units stored under approved transport conditions are acceptable to return to inventory up to 24 h after washing and we provide a prediction interval‐based temperature threshold for rejecting these units, permitting reduced waste.
Diagnostic accuracy and validity of image-assisted versus face-to-face wound assessments for the management of chronic wounds: a systematic review protocol
Authors: Neo Nicholas Wee Siong , Tho Poh Chi 
Published: August 2022

ABSTRACT

Objective:
This review aims to evaluate the accuracy and validity of diagnostic decisions derived from image-assisted wound assessments compared with face-to-face consultations for chronic wound care.

Introduction:
Images are often used within the inpatient, outpatient, and community settings to facilitate interdisciplinary transfer of care, objective wound assessments, and accurate treatment decisions. An ever-changing and ever-improving selection of image-capturing devices has been created and studied in recent years. To improve future chronic wound care programs, there is a need to explore how accurately clinicians can diagnose specific wound characteristics using these images, especially when these devices are operated in the clinical setting.

Inclusion criteria:
Peer-reviewed studies and unpublished/gray literature comparing image-assisted with face-to-face modalities for chronic wound care will be included. Chronic wounds include, but are not limited to, diabetic foot ulcers, ischemic lower limb ulcers, and pressure ulcers. Studies will be excluded if they examine acute wounds or if the reference standard is not face-to-face assessment.

Methods:
A comprehensive search of multiple databases and gray literature sources (MEDLINE, CINAHL, Embase, Web of Science, Scopus, Google Scholar, and ProQuest Central) will be conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Literature published from 2000 onward will be retrieved. Two reviewers will independently screen and appraise the articles. Data extraction and synthesis will be performed based on the JBI methodology for the conduct of diagnostic test accuracy systematic review.

Systematic review registration number:
PROSPERO CRD42021265679
Experience of hope in adult patients with advanced chronic disease and their informal caregivers: a qualitative systematic review protocol
Authors: Befecadu Filipa Baptista Peixoto , Perrenoud Beatrice , Behaghel Ghislaine , Jaques Cécile , Pautex Sophie , Rodrigues Maria Goreti Da Rocha , Larkin Philip Joseph 
Published: August 2022

ABSTRACT

Objective:
This systematic review will evaluate the experience of hope in adult patients with advanced chronic diseases other than cancer, transitioning toward end-of-life. The review will also evaluate the experience of hope in informal caregivers caring for adult patients with advanced chronic diseases other than cancer as they transition toward end-of-life.

Introduction:
Hope is an important resource that assists patients and informal caregivers to deal with difficult and complex situations, such as living with advanced chronic disease.

Inclusion criteria:
The review will include studies written in English, French, and Portuguese exploring hope. Qualitative studies focusing on adult patients with advanced chronic diseases other than cancer and/or informal caregivers will be considered. Studies with children as patients or parents as caregivers will be excluded.

Methods:
The review will search Embase, MEDLINE, CINAHL, PsycINFO, Web of Science, ProQuest Dissertations and Theses, DART-Europe E-theses Portal, and Google Scholar. The search will be conducted without date restrictions. Articles will be assessed against the inclusion criteria by two independent reviewers. Data will be extracted using a standard tool. The extracted findings will be synthesized using the meta-aggregation approach through assembling and categorizing data.

Systematic review registration number:
PROSPERO CRD42021266487
Effectiveness of general practitioner-delivered nutrition care interventions on dietary and health outcomes in adults with diet-related chronic conditions: a systematic review protocol
Authors: Asher Kathryn E. , Somerville Mari , Doucet Shelley , Luke Alison , Ball Lauren , Dombrowski Stephan U. , Hickson Mary , Witherspoon Richelle 
Published: August 2022

ABSTRACT

Objective:
This systematic review will evaluate the effectiveness of nutrition care interventions delivered by general practitioners versus usual care or no care on dietary and health outcomes in adults with diet-related chronic conditions or risk states.

Introduction:
General practitioners are usually the first contacts in the health care system for patients with diet-related chronic conditions. While there is some evidence that general practitioners can be effective in delivering nutrition care for a number of outcomes, to inform future care, an update of the evidence is required as well as an examination of which components are associated with positive outcomes.

Inclusion criteria:
Published studies will be included if they report on adults with or at risk of diet-related chronic conditions; one-on-one nutrition care interventions individually delivered by general practitioners during primary care consultations; usual or no care as comparators; dietary and/or health outcomes with a minimum three-month follow-up; and randomized controlled trials. Included studies will be available in, or able to be translated into, English and will have no date restrictions.

Methods:
The databases to be searched will include CINAHL, Embase, MEDLINE, and ProQuest Nursing and Allied Health. Following deduplication, two reviewers will independently screen the titles and abstracts in Covidence, followed by the full texts of potentially relevant studies. Disagreements will be resolved through discussion or with a third reviewer. Included studies will be critically appraised and data will be extracted using a modified JBI tool. Findings will be reported in tables and narrative synthesis, and pooled with statistical meta-analysis, where possible.

Systematic review registration number:
PROSPERO CRD42021289011
Muscle contraction force conforms to muscle oxygenation during constant‐activation voluntary forearm exercise
Authors: Drouin Patrick J. , Forbes Stacey P. A. , Liu Taylor , Lew Lindsay A. , McGarity‐Shipley Ellen , Tschakovsky Michael E. 
Published: August 2022

New Findings
What is the central question of this study?
In electrically stimulated skeletal muscle, force production is downregulated when oxygen delivery is compromised and rapidly restored upon oxygen delivery restoration. Whether ‘oxygen conforming’ of force production occurs during voluntary muscle activation in humans and whether it is exercise intensity dependent remains unknown.
What is the main finding and its importance?
Here, we show in humans that force at a given voluntary muscle activation does conform to a decrease in oxygen delivery and recovers rapidly and completely with restoration of oxygen delivery. This oxygen‐conforming response of contraction force appears to happen only at higher intensities.
AbstractIn electrically stimulated skeletal muscle, force production is downregulated when oxygen delivery is compromised and rapidly restored upon restoration of oxygen delivery in the absence of cellular disturbance. Whether this ‘oxygen‐conforming’ response of force occurs and is exercise intensity dependent during stable voluntary muscle activation in humans is unknown. In 12 participants (six female), handgrip force, forearm muscle activation (EMG), muscle oxygenation and forearm blood flow (FBF) were measured during rhythmic handgrip exercise at forearm EMG achieving 50, 75 or 90% critical impulse (CI). Four minutes of brachial artery compression to reduce FBF by ∼60% (Hypoperfusion) or sham compression (adjacent to artery; Control) was performed during exercise. Sham compression had no effect. Hypoperfusion rapidly reduced muscle oxygenation at all exercise intensities, resulting in contraction force per muscle activation (force/EMG) progressively declining over 4 min by ∼16% at both 75 and 90% CI. No force/EMG decline occurred at 50% CI. Rapid restoration of muscle oxygenation after compression was closely followed by force/EMG such that it was not different from Control within 30 s for 90% CI and after 90 s for 75% CI. Our findings reveal that an oxygen‐conforming response does occur in voluntary exercising muscle in humans. Within the exercise modality and magnitude of fluctuation of oxygenation in this study, the oxygen‐conforming response appears to be exercise intensity dependent. Mechanisms responsible for this oxygen‐conforming response have implications for exercise tolerance and warrant investigation.
Vibration Analysis of Rotating Combined Thin-Walled Shells With Multiple Conical Segments
Authors: Zhao Changying , Sun Shupeng , Yang Yang , Cao Dengqing 
Published: August 2022

Abstract
In this paper, vibration analysis of rotating combined thin-walled shells with multiple conical segments has been carried out. Considering the centrifugal force, Coriolis force, and initial hoop tension due to rotation, the elastic strain energy and kinetic energy of a single rotating conical shell are expressed based on Love’s first approximation theory. The artificial springs are introduced to simulate the connections of adjacent conical shells and the boundaries of the rotating combined thin-walled shells. Taking characteristic orthogonal polynomial series as the admissible functions, the Rayleigh–Ritz method is employed to derive the frequency equations of the combined shell and corresponding vibration characteristics are then obtained. Given that the cylindrical shell and annular plates can be regarded as conical shells with semi-vertex angles of 0 deg and 90 deg, respectively, the solution given is also available for the vibration analysis of rotating combined thin-walled shells comprised of any segments of cylindrical, conical shell, and annular plate. As examples of rotating combined thin-walled shells with two and five segments, vibrations of rotating conical–conical joined shell and cylindrical–conical–cylindrical–conical–cylindrical joined shell are investigated in the paper. Traveling wave frequencies and corresponding mode shapes are shown, and the effects of rotating speed, circumferential wave number, spring stiffness, and semi-vertex angles on the vibration behavior are given in detail.
A binational analysis of infant mortality among crisis-driven diasporas and those who remain: a population-based study in Colombia and Venezuela
Authors: Garcia Arias Jenny Alejandra , Castro Torres Andres Felipe 
Published: August 2022

ObjectiveTo assess the health cost (or benefit) of crisis-driven migration by focusing on the infant mortality rate (IMR) of the Colombian diaspora in Venezuela and the Venezuelan diaspora in Colombia.MethodsWe compare national to diaspora IMRs over the period 1980-2018. National IMRs are death-to-birth ratios reported by the official vital statistics, whereas diaspora IMRs are calculated by using a semiparametric regression model on the summary birth histories collected in the population censuses. We analyse the diaspora IMRs according to whether their arrival corresponds to precrisis or crisis-driven migration.ResultsDuring crises, diaspora IMRs show better health outcomes than those of non-migrants. The Colombian diaspora had an average annual IMR of −1.8 (95% CI −3.3 to 0.28) per year and the Venezuelan diaspora had −4.5 (95% CI −5.8 to −3.3). However, the protective role of migration is neither guaranteed nor consistent, as a crisis in the country of destination exposes immigrants to worse health outcomes than the non-migrant population.ConclusionMigration is a survival strategy that allows people to reduce the negative effects they face during a crisis in their country of origin. The distinction between crisis-driven and precrisis migration provides a framework for assessing the cross-border effects on health outcomes due to diaspora composition, particularly when populations face adverse conditions.
‘Knowing we have these rights does not always mean we feel free to use them’: athletes’ perceptions of their human rights in sport
Authors: Tuakli-Wosornu Yetsa A , Goutos Demetri , Ramia Ioana , Galea Natalie R , Mountjoy Margo Lynn , Grimm Katharina , Wu Yinfei , Bekker Sheree 
Published: August 2022

ObjectivesModern sport safeguarding strategies include published global rights declarations that enshrine athletes’ entitlements at the policy level. It is unclear how these documents translate to athletes’ lived experiences. The study aimed to determine athletes’ knowledge, attitudes and beliefs about their human rights in sports settings.SettingWeb-based survey.Participants1159 athletes from 70 countries completed a validated web-based survey. Over half of participants (60.1%) were between 18 and 29 years, currently competing (67.1%), not members of players’ unions (54.6%), elite (60.0%) and participating in individual (55.8%) non-contact (75.6%) Olympic (77.9%) sports. Gender distribution was equal.Primary and secondary outcome measuresParticipant demographics (eg, gender, age) and athletes’ knowledge, attitudes and beliefs about their human rights in sports settings.ResultsMost (78.5%) were unaware of any athletes’ rights declarations. Gender influenced participants’ confidence in acting on their rights in sport significantly. Males were more likely to accept pressure from coaches and teammates than females, but age affected how likely males were to accept this pressure. Paralympic athletes were less likely to agree that violence is acceptable in sports, compared with Olympic. Player union membership increased confidence in freely expressing one’s opinion in sports settings. Athletes’ rights-related awareness, knowledge and beliefs were disconnected.ConclusionsAwareness raising is not enough to prevent human rights violations in sports. The cultural climate of the entire ecosystem must be targeted, using systems-level strategies to shift stakeholders’ biases, beliefs and behaviours. This approach takes the onus of addressing abuse off athletes’ shoulders and places accountability on sports organisations.
Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74
Authors: Lee Iris K. , Noguera-Ortega Estela , Xiao Zebin , Todd Leslie , Scholler John , Song Decheng , Liousia Maria , Lohith Katheryn , Xu Kexiang , Edwards Kimberly J. , Farwell Michael D. , June Carl H. , Albelda Steven M. , Puré Ellen , Sellmyer Mark A. 
Published: August 2022

Abstract

Purpose:
Despite the success of chimeric antigen receptor (CAR) T-cell therapy against hematologic malignancies, successful targeting of solid tumors with CAR T cells has been limited by a lack of durable responses and reports of toxicities. Our understanding of the limited therapeutic efficacy in solid tumors could be improved with quantitative tools that allow characterization of CAR T–targeted antigens in tumors and accurate monitoring of response.

Experimental Design:
We used a radiolabeled FAP inhibitor (FAPI) [18F]AlF-FAPI-74 probe to complement ongoing efforts to develop and optimize FAP CAR T cells. The selectivity of the radiotracer for FAP was characterized in vitro, and its ability to monitor changes in FAP expression was evaluated using rodent models of lung cancer.

Results:
[18F]AlF-FAPI-74 showed selective retention in FAP+ cells in vitro, with effective blocking of the uptake in presence of unlabeled FAPI. In vivo, [18F]AlF-FAPI-74 was able to detect FAP expression on tumor cells as well as FAP+ stromal cells in the tumor microenvironment with a high target-to-background ratio. We further demonstrated the utility of the tracer to monitor changes in FAP expression following FAP CAR T-cell therapy, and the PET imaging findings showed a robust correlation with ex vivo analyses.

Conclusions:
This noninvasive imaging approach to interrogate the tumor microenvironment represents an innovative pairing of a diagnostic PET probe with solid tumor CAR T-cell therapy and has the potential to serve as a predictive and pharmacodynamic response biomarker for FAP as well as other stroma-targeted therapies. A PET imaging approach targeting FAP expressed on activated fibroblasts of the tumor stroma has the potential to predict and monitor therapeutic response to FAP-targeted CAR T-cell therapy.
See related commentary by Weber et al., p. 5241
Prediction of Cardiac Resynchronization Therapy Response Using a Lead Placement Score Derived From 4-Dimensional Computed Tomography
Authors: Manohar Ashish , Colvert Gabrielle M. , Yang James , Chen Zhennong , Ledesma-Carbayo Maria J. , Kronborg Mads Brix , Sommer Anders , Nørgaard Bjarne L. , Nielsen Jens Cosedis , McVeigh Elliot R. 
Published: August 2022

Background:
Cardiac resynchronization therapy (CRT) is an effective treatment for patients with heart failure; however, 30% of patients do not respond to the treatment. We sought to derive patient-specific left ventricle maps of lead placement scores (LPS) that highlight target pacing lead sites for achieving a higher probability of CRT response.

Methods:
Eighty-two subjects recruited for the ImagingCRT trial (Empiric Versus Imaging Guided Left Ventricular Lead Placement in Cardiac Resynchronization Therapy) were retrospectively analyzed. All 82 subjects had 2 contrast-enhanced full cardiac cycle 4-dimensional computed tomography scans: a baseline and a 6-month follow-up scan. CRT response was defined as a reduction in computed tomography–derived end-systolic volume ≥15%. Eight left ventricle features derived from the baseline scans were used to train a support vector machine via a bagging approach. An LPS map over the left ventricle was created for each subject as a linear combination of the support vector machine feature weights and the subject’s own feature vector. Performance for distinguishing responders was performed on the original 82 subjects.

Results:

Fifty-two (63%) subjects were responders. Subjects with an LPS≤Q
1
(lower-quartile) had a posttest probability of responding of 14% (3/21), while subjects with an LPS≥ Q
3
(upper-quartile) had a posttest probability of responding of 90% (19/21). Subjects with Q
1
<LPS<Q
3
had a posttest probability of responding that was essentially unchanged from the pretest probability (75% versus 63%,
P
=0.2). An LPS threshold that maximized the geometric mean of true-negative and true-positive rates identified 26/30 of the nonresponders. The area under the curve of the receiver operating characteristic curve for identifying responders with an LPS threshold was 87%.

Conclusions:
An LPS map was defined using 4-dimensional computed tomography–derived features of left ventricular mechanics. The LPS correlated with CRT response, reclassifying 25% of the subjects into low probability of response, 25% into high probability of response, and 50% unchanged. These encouraging results highlight the potential utility of 4-dimensional computed tomography in guiding patient selection for CRT. The present findings need verification in larger independent data sets and prospective trials.
Presence of Coronary Endothelial Dysfunction, Coronary Vasospasm, and Adenosine-Mediated Vasodilatory Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries
Authors: Feenstra Rutger G.T. , Boerhout Coen K.M. , Woudstra Janneke , Vink Caitlin E.M. , Wittekoek Marianne E. , de Waard Guus A. , Appelman Yolande , Eringa Etto C. , Marques Koen M.J. , de Winter Robbert J. , Beijk Marcel A.M. , van de Hoef Tim P. , Piek Jan J. 
Published: August 2022

Background:
Coronary function testing in patients with ischemia and nonobstructive coronary arteries (INOCA) commonly includes assessment of adenosine-mediated vasodilation and acetylcholine spasm provocation. The purpose of this study was to evaluate the diagnostic value of additional endothelial function testing for the diagnosis of vasomotor dysfunction in patients with INOCA.

Methods:
In this retrospective cohort study, we included patients with INOCA who underwent clinically indicated comprehensive coronary function testing. Endothelial dysfunction was defined as a <50% increase in coronary blood flow, determined by Doppler flow, and/or epicardial vasoconstriction compared to baseline, in response to low-dose acetylcholine. Coronary artery spasm (CAS) was defined as vasospastic angina or microvascular angina in response to coronary high-dose acetylcholine. An impaired adenosine-mediated vasodilation was defined as a coronary flow reserve <2.5 and/or hyperemic microvascular resistance ≥2.5.

Results:
Among all 110 patients, 79% had endothelial dysfunction, 62% had CAS, and 29% had an impaired adenosine-mediated vasodilation. Endothelial dysfunction was present in 80% of patients who tested positively for CAS and/or an impaired adenosine-mediated vasodilation. Endothelial function testing increases the diagnostic yield of coronary function testing that only incorporates adenosine testing and spasm provocation by 17% to 92%. Of patients with normal adenosine-mediated vasodilation and no inducible CAS, 68% had endothelial dysfunction.

Conclusions:
Concomitant endothelial dysfunction was prevalent in the vast majority of patients with INOCA with inducible CAS and/or an impaired adenosine-mediated vasodilation. In patients with INOCA without inducible CAS and normal adenosine-mediated vasodilation, two-thirds had endothelial dysfunction. These results indicate the relevance to perform endothelial function testing in patients with INOCA in view of its therapeutic implication.