bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state
Authors: Packebush Maxwell H. , Sanchez-Martinez Silvia , Biswas Sourav , Shraddha KC , Nguyen Kenny , Boothby Thomas C. 
Published: November 2022

AbstractBiologics, pharmaceuticals containing or derived from living organisms, such as vaccines, antibodies, stem cells, blood, and blood products are a cornerstone of modern medicine. However, nearly all biologics have a major deficiency: they are inherently unstable, requiring storage under constant cold conditions. The so-called ‘cold-chain’, while effective, represents a serious economic and logistical hurdle for deploying biologics in remote, underdeveloped, or austere settings where access to cold-chain infrastructure ranging from refrigerators and freezers to stable electricity is limited. To address this issue, we explore the possibility of using anhydrobiosis, the ability of organisms such as tardigrades to enter a reversible state of suspended animation brought on by extreme drying, as a jumping off point in the development of dry storage technology that would allow biologics to be kept in a desiccated state under ambient or even elevated temperatures. Here we examine the ability of different protein and sugar-based mediators of anhydrobiosis derived from tardigrades and other anhydrobiotic organisms to stabilize Human Blood Clotting Factor VIII under repeated dehydration/rehydration cycles, thermal stress, and long-term dry storage conditions. We find that while both protein and sugarbased protectants can stabilize the biologic pharmaceutical Human Blood Clotting Factor FVIII under all these conditions, protein-based mediators offer more accessible avenues for engineering and thus tuning of protective function. Using classic protein engineering approaches, we fine tune the biophysical properties of a protein-based mediator of anhydrobiosis derived from a tardigrade, CAHS D. Modulating the ability of CAHS D to form hydrogels made the protein better or worse at providing protection to Human Blood Clotting Factor VIII under different conditions. This study demonstrates the effectiveness of tardigrade CAHS proteins and other mediators of desiccation tolerance at preserving the function of a biologic without the need for the cold-chain. In addition, our study demonstrates that engineering approaches can tune natural products to serve specific protective functions, such as coping with desiccation cyclingversusthermal stress. Ultimately, these findings provide a proof of principle that our reliance on the cold-chain to stabilize life-saving pharmaceuticals can be broken using natural and engineered mediators of desiccation tolerance.
The InterACT Disability Arts Festival: creating revolutionary futures?
Authors: Walters Trudie 
Published: November 2022

PurposeThis exploratory study seeks to understand whether an arts event designed with/by/for disabled people (the InterACT Disability Arts Festival in New Zealand) has the potential to create revolutionary futures, defined as those which help determine new paths, make the future less fearsome and allow more positive outcomes.Design/methodology/approachA qualitative approach was taken in this study. Interviews were carried out with ten disabled event attendees, two support workers, one family member, four event volunteers, two activity providers and the main event organiser of the 2019 festival. Active participant observation was also used to collect data. Deductive thematic analysis was used to determine themes and subthemes in the material.FindingsThe findings suggest the case study arts event does help to create revolutionary futures for disabled attendees through disrupting the narratives of disability, making sense of lives lived and changing lives yet to be lived.Research limitations/implicationsLimited windows of opportunity were available to interact with attendees, and just 17 in-the-moment interviews were conducted. However, the findings still have value as data saturation was reached. A “revolutionary futures” conceptual framework is presented to understand the nexus between disability worlds and events and thus amplify the benefits for attendees.Originality/valueResearch carried out to date has provided much-needed understanding about the challenges facing disabled people at events, but this study turns this deficit approach around to focus on the opportunities provided by event participation.
Understanding Islamic accounting: a Quranic approach
Authors: Zaky Achmad , Warsono Sony 
Published: November 2022

Purpose
This study aims to identify the effect of the Quranic approach on understanding Islamic accounting among accounting students.

Design/methodology/approach
This study used an experimental field design with pre- and post-test involving 107 participants. Based on the self-determination theory, this study explores the role of Quranic involvement in Islamic accounting instructional design to improve learning outcomes. This study used a comparative analysis of an independent sample of the approach (Quranic vs technical learning) in instructional design (mathematics vs conventional).

Findings
This study proves that Islamic accounting learning outcomes differ between the Quranic and technical learning approaches. The Quranic approach provides better learning outcomes based on post-test scores. This difference is consistent in both conventional and mathematical instructional designs.

Research limitations/implications
First, this study is limited to the alleged role of the Quranic approach in participants' intrinsic motivation. Further studies can explore how and what part of participants' intrinsic motivation is affected by the Quranic approach. Second, this research is limited to the basics of Islamic accounting. Further studies can explore the role of the Quranic approach in understanding Islamic accounting transactions with higher complexity.

Practical implications
This study can be used to develop Islamic accounting instructional designs using a Quranic approach.

Originality/value
This study provides empirical evidence on the Quranic approach's role in improving learning outcomes. This study also fills in the scarcity of research on Islamic accounting teaching.
CSR in major European football leagues in the age of COVID-19: financial vulnerability, mental health and domestic violence
Authors: Ahmed Jashim Uddin , Hasan Md. Kamrul , Islam Quazi Tafsirul , Uddin Mohammad Jasim , Faroque Anisur R. , Chowdhury Md. Humayun Kabir 
Published: November 2022

Purpose
COVID-19 pandemic has significantly impacted the lives of people and businesses around the world in different ways. France, Spain, Italy and the UK are among the worst affected countries by this pandemic. The purpose of this paper is to identify and compare different corporate social responsibility (CSR) activities taken by the clubs and player of the major football leagues of these four countries to develop a more comprehensive model of intervention.

Design/methodology/approach
This paper has analyzed the initiatives taken by these football clubs and players to address financial vulnerabilities, mental health problems and domestic violence among the stakeholders and compared them with the existing CSR and humanitarian models. A case study approach has been used to collect and analyze data related to the CSR activities taken by the players and club management. Official websites of the clubs, newspaper and journal articles were among the major sources used to collect data for the paper.

Findings
Football clubs and players of the four major leagues have raised funds through different campaigns and delivered foods and essential medical supplies to the communities and hospitals to address financial vulnerabilities, mental health issues and domestic violence within their communities during the COVID-19 pandemic. They have provided guidance to their followers using social and television media to improve their physical and mental health during the pandemic. Online competitions, quizzes or virtual hangouts have also been used by the players to engage the stakeholders on a frequent basis. Football clubs have also initiated campaigns to raise awareness within the community on available medical services for the victims of domestic violence and also provided them with shelter, food, medical, legal and online counseling services.

Originality/value
Football clubs and players of the major leagues were always at the forefront to help the communities and hospitals to address issues related to mental health problems, financial vulnerabilities and domestic violence during the COVID-19 pandemic. The findings of this paper could help and guide other entities in designing a more comprehensive model of CSR interventions during pandemics or crisis situations to address financial vulnerabilities, mental health problems and domestic violence within their communities.
Diel and seasonal changes in gut contents of omnivorous–carnivorous macroinvertebrates in the Yura River, Japan
Authors: Nakagawa Hikaru 
Published: November 2022

AbstractDiel and seasonal changes in the gut contents of omnivorous–carnivorous macroinvertebrates were examined in a Japanese mountain stream based on direct observation of gut contents. Carnivorous–omnivorous (predator) macroinvertebrates were sampled at four time periods (02:00–03:00, 08:00–09:00, 14:00–15:00, and 20:00–21:00) on 3 days in each of March, June, September, and December. A total of 1391 individual macroinvertebrates belonging to 71 taxa were dissected: identifiable gut contents were observed in 928 individuals and prey identified to the family level were observed from the guts of 564 individuals. Using nonmetric multidimensional scaling, interspecific variation in foraging patterns was summarized into two axes that approximately correspond to body size and habitat preferences of prey taxa. Although seasonal patterns in the number of prey individuals in a gut varied among taxa, in March and December, several predators notably foraged on taxa such as Simuliidae, which inhabits stone surfaces in river sections with a rapid current. This pattern may be explained by season‐specific prey availability and predation risks from vertebrates. Diel changing patterns in the number of prey individuals per gut varied among predator taxa, and most predators did not show obvious proportional changes in gut contents. These results indicate that subcompartments of interaction networks and numerous indirect effects via intraguild predation potentially exist within the “guild” of macroinvertebrates, which are often summarized as mesopredators of stream food webs.
Community resistance and the role of justice in shale gas development in the United Kingdom
Authors: Sherval Meg 
Published: November 2022

AbstractGlobal energy policies embracing a transition to unconventional oil and gas development are hallmarks of many developed nations. Among these, the United Kingdom has framed the development of shale gas as one means to transition from high‐carbon fossil‐fuel consumption to low‐carbon alternatives. Yet the introduction of this industry and recent legislation associated with it have not been without controversy. Communities throughout the United Kingdom are engaged in sustained debates concerning climate change, health, the scale of extraction footprints, securitisation, and governance. Places such as Kirby Misperton, the focus of this article, are representative of many villages where questions abound about the role of justice at all stages and scales of governmental decision‐making. Using a legal geographic lens, this article examines narratives among local residents who are actively resisting the arrival of unconventional gas. I consider how the relationships between and among energy transition, policy, and justice have been interpreted by communities and argue for inequity and risk to be addressed in more transparent ways. I contend that highlighting counter‐narratives remains essential if powerful arguments by governments and others are to be negated. Fundamentally, true justice can only prevail when all stakeholders are considered legitimate and their opinions valid.
An ʿAqaba/Ayla‐type amphora in the sultanate of Oman
Authors: Yule Paul A. 
Published: November 2022

AbstractAntique trade amphorae illuminate a little understood but important find category for Arabia, still in the twilight of publication. Most of the find data lie buried in unpublished work regarding recent excavations at ʿAqaba/Ayla. Recent research has verified mineralogically the origin of these documents and their dating. An example fortuitously found forms the basis of this find note.
Fentanyl withdrawal: Understanding symptom severity and exploring the role of body mass index on withdrawal symptoms and clearance
Authors: Luba Rachel , Jones Jermaine , Choi C. Jean , Comer Sandra 
Published: November 2022

AbstractBackground and AimsFentanyl is a highly lipophilic mu opioid receptor agonist, increasingly found in heroin and other drug supplies, that is contributing to marked increases in opioid‐related overdose and may be complicating treatment of opioid use disorder (OUD). This study aimed to measure the influence of body mass index (BMI) on fentanyl withdrawal and clearance.Design, Setting, ParticipantsThis secondary analysis, from a 10‐day inpatient study on the safety and efficacy of sublingual dexmedetomidine for opioid withdrawal, includes participants with OUD (n = 150) recruited from three sites in New York, New Jersey and Florida, who were maintained on oral morphine (30 mg four times per day) for 5 days before starting study medication. Most participants (n = 118) tested positive for fentanyl on admission to the inpatient unit.MeasurementsUrine toxicology and opioid withdrawal symptoms [Clinical Opioid Withdrawal Scale (COWS) and Short Opiate Withdrawal Scale (SOWS)] were assessed daily. The present analysis includes data on opioid withdrawal from days 1–5 of stabilization and urine toxicology data from days 1–10.FindingsFentanyl status at admission was not significantly associated with COWS or SOWS scores after adjusting for sex, site and polysubstance use. Participants classified as overweight or obese (n = 66) had significantly higher odds of testing positive for fentanyl across days 1–10 [odds ratio (OR) = 1.65; P < 0.01] and higher SOWS maximum scores across morphine stabilization (P < 0.05) compared to those with a healthy BMI (n = 68).ConclusionsAmong inpatients with opioid use disorder, fentanyl status does not appear to be statistically significantly associated with Clinical Opioid Withdrawal Scale and Short Opiate Withdrawal Scale mean and maximum scores. High body mass index status (overweight or obese) appears to be an important predictor of slower fentanyl clearance and higher Short Opiate Withdrawal Scale maximum scores across the inpatient period than lower body mass index status.
The impact of a run‐of‐the‐river hydroelectric dam on a non‐volant small‐mammal assemblage in Brazilian Amazonia
Authors: Araujo Raylenne da Silva , Bobrowiec Paulo Estefano Dineli , de Moura Raquel Teixeira , Magnusson William Ernest 
Published: November 2022

AbstractThere are few scientific studies evaluating the impact of the loss of wetlands on the banks of tropical rivers on assemblages of small non‐flying mammals. To understand the possible deleterious effects of hydroelectric construction in tropical forests on this group of mammals, we used data from 2 years of monitoring carried out during the period before the filling of a hydroelectric plant reservoir in the Brazilian Amazon, and related them to vegetation, soil and topography. We captured 659 individuals of 20 small‐mammal species. The species assemblage composition in the flooded areas was a subset of species that occurred in both floodable and non‐floodable areas, and only one species was captured exclusively in the flooded area. Species composition was influenced by the proportion of sand, by soil nutrient concentration and distance from water bodies. We conclude that there is no evidence that the flooding of low‐lying areas along the Madeira River would negatively affect the assemblage of non‐flying small mammals in the short term because the remaining areas have similar assemblages of small mammals as those destined for flooding. Whether the area lost will be important for population dynamics will depend on the conservation of the remaining areas.
Patient blood management using dedicated personnel in the operating room—you get what you pay for
Authors: Gammon Richard R. 
Published: November 2022

SummaryA patient blood management (PBM) strategy can be applied to the process of intraoperative cell salvage for re‐infusion during surgery. Stoneham et al. describe an effective PBM strategy applied to abdominal aortic aneurysm repair and emphasise the importance of a qualified and experienced intraoperative cell salvage practitioner to improve the safety and effectiveness of the approach.Commentary on: Stoneham et al. Intraoperative cell salvage using swab wash and serial thromboelastography in elective abdominal aortic aneurysm surgery involving massive blood loss. Br J Haematol 2023;200:652‐659.
Humoral response to mRNA‐based COVID‐19 vaccine in patients with immune thrombocytopenia
Authors: Mori Akio , Onozawa Masahiro , Kobayashi Mirei , Tsukamoto Shihori , Senjo Hajime , Ishio Takashi , Yokoyama Emi , Izumiyama Koh , Saito Makoto , Muraki Haruna , Morioka Masanobu , Teshima Takanori , Kondo Takeshi 
Published: November 2022

SummaryData for COVID‐19 vaccine response in patients with immune thrombocytopenia (ITP) are very limited. In a study of 28 patients with ITP, anti‐severe acute respiratory syndrome coronavirus 2 spike antibody titres were measured after vaccination. The seroconversion rate for ITP patients was 91.3%, comparable to that in healthy controls (HCs). However, the antibody titre in ITP patients was significantly lower than that in HCs and declined with ageing. Furthermore, the antibody titre in ITP patients who received a minimum prednisolone dose of at least 5 mg/day at any time‐point at or after initial vaccination was lower than that in other patients.
Economic inequality breeds corrupt behaviour
Authors: Wei Cong , Dang Jianning , Liu Li , Li Chao , Tan Xuyun , Gu Zibei 
Published: November 2022

AbstractEconomists and political scientists have long debated the relations between economic inequality and corruption at the societal level. Extending this literature, we proposed and tested that economic inequality breeds the corrupt behaviour of individuals. Analyses of 45‐year archival data from the United States found that official corruption crimes were more prevalent in years and states with greater economic inequality. Three subsequent experiments (N = 776) using economic games showed that individuals exposed to greater economic inequality exhibited more corrupt behaviour in both Chinese and American cultures. Furthermore, the increased desire for wealth and the perception of reduced fairness accounted for this effect. These findings highlight that excessive economic inequality creates a competitive environment in which people give priority to themselves over others and suggest a vicious cycle between economic inequality and corruption.
Architecture, formation and implication of active structure‐controlled intraslope channel system southeast offshore Sendai, Tohoku, Japan
Authors: Chang Jih‐Hsin , Inoue Takahiko , Misawa Ayanori , Arai Kohsaku 
Published: November 2022

AbstractLocated off the Pacific coast of central Tohoku (NE Japan), the Ishinomaki slope channel (ISC) provides an excellent opportunity to study a structure‐controlled intraslope channel and downslope sedimentation along the active margin. The seismic reflection data across ISC show an extensive basal surface and overlying channel complexes between the basement structures of the Abukuma ridge to the south and Kitakami massif to the north, indicating that the formation of the intraslope basin, channelization of ISC and sedimentation of the downstream channel‐lobe transition zone (CLTZ) are very likely to be structure‐controlled. The oblique channel stacking pattern, faulting of the seafloor and subsurface Abukuma ridge in the upper and lower domains of ISC, collectively suggest that ISC has migrated northward and is currently under the influence of active compression. Differences in styles of accommodation space between the upper and lower domains of ISC suggest that differential subsidence occurred along the strike‐slip tectonic line. Based on the regional strike‐slip tectonic line, we propose that a Kitakami‐Abukuma ridge existed before the formation of ISC. The strike‐slip faulting divided the Kitakami‐Abukuma ridge into the Kitakami massif to the north and the Abukuma ridge to the south, and an intervening fault trough as the precursor of the intraslope basin and ISC. As the subduction of the Pacific Plate and associated compressional events continued, the Abukuma ridge was reactivated to narrow the intraslope basin into a confined channel. Located near the epicentre of the devastating 2011 Tohoku earthquake event, the ISC, downstream CLTZ and underlying intraslope basin provide information on active basement structure and the evolving sediment routing system on the tectonically active margin.
Solutions to fire and shade: resprouting, growing tall and the origin of Eurasian temperate broadleaved forest
Authors: Adie Hylton , Lawes Michael J. 
Published: November 2022

ABSTRACTTree species of Eurasian broadleaved forest possess two divergent trait syndromes with contrasting patterns of resource allocation adapted to different selection environments: short‐stature basal resprouters that divert resources to a bud bank adapted to frequent and severe disturbances such as fire and herbivory, and tall trees that delay reproduction by investing in rapid height growth to escape shading. Drawing on theory developed in savanna ecosystems, we propose a conceptual framework showing that the possession of contrasting trait syndromes is essential for the persistence of broadleaved trees in an open ecosystem that burns. Consistent with this hypothesis, trees of modern Eurasian broadleaved forest bear a suite of traits that are adaptive to surface and crown‐fire regimes. We contend that limited opportunities in grassland restricts recruitment to disturbance‐free refugia, and en masse establishment creates a wooded environment where shade limits the growth of light‐demanding savanna plants. Rapid height growth, which involves investment in structural support and the switch from a multi‐stemmed to a monopodial growth form, is adaptive in this shaded environment. Although clustering reduces surface fuel loads, these establishment nuclei are vulnerable to high‐intensity crown fires. The lethal effects of canopy fire are avoided by seasonal leaf shedding, and aerial resprouting enhances rapid post‐fire recovery of photosynthetic capacity. While these woody formations satisfy the structural definition of forest, their constituents are clearly derived from savanna. Contrasting trait syndromes thus represent the shift from consumer to resource regulation in savanna ecosystems. Consistent with global trends, the diversification of most contemporary broadleaved taxa coincided with the spread of grasslands, a surge in fire activity and a decline in wooded ecosystems in the late Miocene–Pliocene. Recognition that Eurasian broadleaved forest has savanna origins and persists as an alternative state with adjacent grassy ecosystems has far‐reaching management implications in accordance with functional rather than structural criteria. Shade is a severe constraint to the regeneration and growth of both woody and herbaceous growth forms in consumer‐regulated ecosystems. However, these ecosystems are highly resilient to disturbance, an essential process that maintains diversity especially among the species‐rich herbaceous component that is vulnerable to shading when consumer behaviour is altered.