bluuebunny/crossref_metadata_2025_split huggingface dataset:
Negative temperature dependence of statolith Sr/Ca and its intraspecific variability in experimentally maintained spear squid Heterololigo bleekeri
Authors: Hosono Shota , Irie Takahiro , Yamamoto Jun , Nakaya Mitsuhiro , Sakurai Yasunori , Kawamura Tomohiko , Iwata Yoko 
Published: August 2022

AbstractThe strontium-to-calcium ratio (Sr/Ca) in aragonitic shells and statoliths often depends on temperature, and has been investigated for its potential availability as a sclerochronological record of the temperatures experienced during the life of the animal. Only a few cephalopod species have been subjected to rearing experiments to validate the temperature dependence of statolith Sr/Ca despite the strong demand for estimating their historical ecology, particularly of migratory squid populations. In this context, we examined the relationship between temperature and statolith Sr/Ca in the spear squid, Heterololigo bleekeri, by maintaining wild-caught immature individuals at one of three constant temperatures: 12, 14 or 16°C. A portion of statolith precipitated during the experiment was optically identified by daily increment analysis, and then subjected to Sr/Ca measurement using an electron probe micro-analyser. Regression analysis (N = 29) demonstrated the dependence of statolith Sr/Ca on temperature and the relationship was estimated as an equation Y = 9.93 (±0.29) − 0.11 (±0.02) X. However, ~90% of the total residual variance was accounted for by the among-individual variation of statolith Sr/Ca within each temperature group. Consequently, the 95% confidence interval ranged over ± 7.85°C when the temperature was estimated by inserting a Sr/Ca value into this equation. The statolith Sr/Ca values are unlikely to provide reliable estimates for absolute temperatures, but it may allow reconstruction of a time-series of relative temperatures experienced by a particular individual.
Sharing in nature or encountering a person: A tale of two different supralapsarian strategies
Authors: van Driel Edwin Chr. 
Published: August 2022

AbstractSupralapsarian christologies all hold that the incarnation is not contingent upon sin but may differ on the nature of the gift given to us in the incarnation. In this essay I conceptualize and evaluate a crucial difference between two supralapsarian strategies. One strategy, exemplified by Kathryn Tanner, focuses on the natures of the incarnate One: it argues that in the incarnation the Word takes on a human nature which, being transformed in the act of assumption, becomes the conduit of grace for those who share in the same humanity. The other, represented by Samuel Wells, thinks of the incarnation as a gift of a transforming presence of the incarnate person. In taking on human form, the person of the divine Word comes as close to us as God can – the invisible God now can be seen, touched, heard – and draws us into a community of friendship and love.
God's definite command? Some theological thoughts on a puzzling theme in Barth's ethics
Authors: Bartholomaeus Michael 
Published: August 2022

AbstractOne of the most puzzling features of Barth's ethics is the insistence that God's divine command encounters us so definitely and concretely that it simply requires immediate and unquestioning obedience. This article offers an interpretation of these comments by reading them through the framework of Barth's description of the secularity, one-sidedness and spirituality of God's Word in Church Dogmatics I/1. Such a reading suggests that Barth's comments are not promoting a foolproof and immediate way of adjudicating ethical quandaries but orient us to the commanding Lord who goes before us.
Articulating the atonement: Methodology and metaphor in atonement theology
Authors: Hartley William J. O. 
Published: August 2022

AbstractDoctrines of the atonement have tended either to elevate the status of one biblical metaphor or to gather together various metaphors into a unified concept or chorus of equal metaphors. The purpose of this article is to shed light on how the biblical metaphors function, using by way of reference the contrasting interpretations of Charles Hodge and Joel Green, who tend towards opposing theories of language based on naïve realism and idealism respectively. Drawing on the work of Colin Gunton, I recommend a mediating approach based on a critical realist theory of language which aims to steer a middle course between rationalism and relativism. Such an approach, which values the epistemic and revelatory potential of metaphors, is facilitated by a more integrative theological method with respect to scripture, reason, tradition and experience.
Psalms for restless memory: The logic of grace and rest in Augustine's Confessions
Authors: Shin Euntaek D. 
Published: August 2022

AbstractThe notion of rest frames Augustine's Confessions: the expression of the desire for rest and the prayer for God's bestowal of rest. Between these bookends is an extended account of Augustine's past expressed in the form of a confession, one that is saturated with the Psalms. How are these major motifs – rest, memory, confession and the Psalms – related? And how do they relate to the seemingly paradoxical depiction of Augustine's own striving towards rest and God's bestowal of rest? This essay answers these questions by delineating the logic of grace and rest embedded in the Confessions.
Differential exposure to gun or knife violence over two decades is associated with sibling differences in depression
Authors: Jaffee Sara R. , Hasford Stephanie , Fein Joel A. 
Published: August 2022

AbstractWe tested whether exposure to gun or knife violence over two decades is a cause of depression in young adulthood using data from a nationally representative sample in the United States. The National Longitudinal Study of Adolescent to Adult Health is a sample of 20,745 adolescents, assessed in 1994–95 with follow-ups in 1995–1996 (n = 14,738), 2001–2002 (n = 15,197) and 2007–2008 (n = 15,701; 24 to 32 years old). At each wave, respondents reported exposure to gun or knife violence and symptoms of depression. Regression and sibling fixed effects analyses were conducted to test whether cumulative exposure to gun or knife violence was associated with depression. In fully adjusted models, greater cumulative exposure to gun or knife violence was associated with more symptoms of depression (b = 0.12, 95% C. I. = 0.05; 0.19, p < 0.01) and higher risk for clinically significant depression in young adulthood (OR = 1.07, 95% C. I. = 1.02; 1.13, p < 0.01). Results replicated in sibling fixed effects models (b = 0.21, 95% C. I. = 0.01; 0.42, p < 0.05). These quasi-experimental data suggest that exposure to gun or knife violence is a cause of depression in young adulthood.
Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples
Authors: Elam Kit K. , Bountress Kaitlin E. , Ha Thao , Shaw Daniel S. , Wilson Melvin N. , Aliev Fazil , Dick Danielle M. , Lemery-Chalfant Kathryn 
Published: August 2022

AbstractExternalizing behavior in early adolescence is associated with alcohol use in adolescence and early adulthood and these behaviors often emerge as part of a developmental sequence. This pattern can be the result of heterotypic continuity, in which different behaviors emerge over time based on an underlying shared etiology. In particular, there is largely a shared genetic etiology underlying externalizing and substance use behaviors. We examined whether polygenic risk for alcohol use disorder predicted (1) externalizing behavior in early adolescence and alcohol use in adolescence in the Early Steps Multisite sample and (2) externalizing behavior in adolescence and alcohol use in early adulthood in the Project Alliance 1 (PAL1) sample. We examined associations separately for African Americans and European Americans. When examining European Americans in the Early Steps sample, greater polygenic risk was associated with externalizing behavior in early adolescence. In European Americans in PAL1, we found greater polygenic risk was associated with alcohol use in early adulthood. Effects were largely absent in African Americans in both samples. Results imply that genetic predisposition for alcohol use disorder may increase risk for externalizing and alcohol use as these behaviors emerge developmentally.
Manifesto of a Space Scientist
Authors: Gombosi Tamas I. 
Published: August 2022

AbstractIn my five decades as a space scientist I experienced many successes, failures, struggles and joys of solving important (and not so important) problems. I documented my story in my book “Phoenix” (Gombosi, 2013, https://www.amazon.com/Phoenix‐Tamas‐I‐Gombosi‐2013‐12‐03/dp/B01FKUSX5I) and up‐to‐date information about my work can be found at my personal website (Gombosi, 2022, http://www-personal.umich.edu/∼tamas/). In this article I am summarizing some of the lessons I learned. I hope you will find my “manifesto” useful and entertaining. Each point has real life experience to support it. Together, they pretty much summarize my philosophy of scientific research, project management and leadership.
A Micro Mid‐Infrared Spectroscopic Study of Chang’e‐5 Sample
Authors: Yang Yazhou , Jiang Te , Liu Yang , Xu Yuchen , Zhang Hao , Tian Heng‐Ci , Yang Wei , Zou Yongliao 
Published: August 2022

AbstractThe Chang’e‐5 (CE‐5) mission has successfully returned samples from a site that is much younger than the sites of all previous lunar sampling missions. Sample analysis results reported so far have revealed a more complex sampling area than previously thought, casting uncertainties over the interpretation of remote sensing spectral data and the U and Th abundance derived from the orbital data. Laboratory spectral measurement of the returned samples can serve as validation of remote sensing observations and thus help refine our understanding of the geological evolution of the landing region. In this study we report detailed micro mid‐infrared (MIR) spectral characteristics of individual soil grains of CE‐5 samples. The spectral analysis results show that the CE‐5 olivine grains have low Fo (molar Mg/[Mg + Fe] × 100) consistent with previous studies, indicating a Fe‐rich source region of the mantle or a highly evolved magma. These olivine grains show high level of crystallinity, implying low degree of space weathering. Most of the CE‐5 glasses analyzed are spectrally consistent with mare impact glasses, despite that a few of them may have a volcanic origin. These laboratory spectral analysis of CE‐5 samples in the MIR wavelengths at a micro scale, together with the derived MIR optical constants of the olivine, pyroxene, plagioclase, and glass grains, provide important input for the modeling and interpretation of thermal remote sensing data of the Moon.
Molecular diagnose of a large hearing loss population from China by targeted genome sequencing
Authors: Wu Jie , Cao Zongfu , Su Yu , Wang Yang , Cai Ruikun , Chen Jiyue , Gao Bo , Han Mingyu , Li Xiaohong , Zhang DeJun , Gao Xue , Huang Shasha , Huang Quanfei , Yuan Yongyi , Ma Xu , Dai Pu 
Published: August 2022

AbstractHereditary hearing loss is genetically heterogeneous, with diverse clinical manifestations. Here we performed targeted genome sequencing of 227 hearing loss related genes in 1027 patients with bilateral hearing loss and 520 healthy volunteers with normal hearing to comprehensively identify the molecular etiology of hereditary hearing loss in a large cohort from China. We obtained a diagnostic rate of 57.25% (588/1027) for the patients, while 4.67% (48/1027) of the patients were identified with uncertain diagnoses. Of the implicated 35 hearing loss genes, three common genes, including SLC26A4(278/588), GJB2(207/588), MT-RNR1(19/588), accounted for 85.54% (503/588) of the diagnosed cases, while 32 uncommon hearing loss genes, including MYO15A, MITF, OTOF, POU3F4, PTPN11, etc. accounted for the remaining diagnostic rate of 14.46% (85/588). Apart from Pendred syndrome, other eight types of syndromic hearing loss were also identified. Of the 64 uncertain significant variants and 244 pathogenic/likely pathogenic variants identified in the patients, 129 novel variants were also detected. Thus, the molecular etiology presented with high heterogeneity with the leading causes to be SLC26A4 and GJB2 genes in the Chinese hearing loss population. It’s urgent to develop a database of the ethnicity-matched healthy population as well as to perform functional studies for further classification of uncertain significant variants.
Upconversion FRET quantitation: the role of donor photoexcitation mode and compositional architecture on the decay and intensity based responses
Authors: Kotulska Agata M. , Pilch-Wróbel Aleksandra , Lahtinen Satu , Soukka Tero , Bednarkiewicz Artur 
Published: August 2022

AbstractLanthanide-doped colloidal nanoparticles capable of photon upconversion (UC) offer long luminescence lifetimes, narrowband absorption and emission spectra, and efficient anti-Stokes emission. These features are highly advantageous for Förster Resonance Energy Transfer (FRET) based detection. Upconverting nanoparticles (UCNPs) as donors may solve the existing problems of molecular FRET systems, such as photobleaching and limitations in quantitative analysis, but these new labels also bring new challenges. Here we have studied the impact of the core-shell compositional architecture of upconverting nanoparticle donors and the mode of photoexcitation on the performance of UC-FRET from UCNPs to Rose Bengal (RB) molecular acceptor. We have quantitatively compared luminescence rise and decay kinetics of Er3+ emission using core-only NaYF4: 20% Yb, 2% Er and core-shell NaYF4: 20% Yb @ NaYF4: 20% Yb, 5% Er donor UCNPs under three photoexcitation schemes: (1) direct short-pulse photoexcitation of Er3+ at 520 nm; indirect photoexcitation of Er3+ through Yb3+ sensitizer with (2) 980 nm short (5–7 ns) or (3) 980 nm long (4 ms) laser pulses. The donor luminescence kinetics and steady-state emission spectra differed between the UCNP architectures and excitation schemes. Aiming for highly sensitive kinetic upconversion FRET-based biomolecular assays, the experimental results underline the complexity of the excitation and energy-migration mechanisms affecting the Er3+ donor responses and suggest ways to optimize the photoexcitation scheme and the architecture of the UCNPs used as luminescent donors.
Outcomes of renal transplantation in patients with AL amyloidosis: an international collaboration through The International Kidney and Monoclonal Gammopathy Research Group
Authors: Havasi Andrea , Heybeli Cihan , Leung Nelson , Angel-Korman Avital , Sanchorawala Vaishali , Cohen Oliver , Wechalekar Ashutosh , Bridoux Frank , Jaffer Insara , Gutgarts Victoria , Hassoun Hani , Levinson Maya , Rosenbaum Cara , Milani Paolo , Palladini Giovanni , Merlini Giampaolo , Hegenbart Ute , Schönland Stefan , Veelken Kaya , Pogrebinsky Alexander , Doros Gheorghe , Landau Heather 
Published: August 2022

AbstractEffective systemic therapies suppress toxic light chain production leading to an increased proportion of patients with light chain (AL) amyloidosis who survive longer albeit with end-stage renal disease. There is a critical need to identify patients in this population who benefit from renal transplantation. This multicenter, observational study from five countries includes 237 patients with AL amyloidosis who underwent renal transplantation between 1987 and 2020. With a median follow-up of 8.5 years, the median overall survival from renal transplantation was 8.6 years and was significantly longer in patients with complete and very good partial hematologic responses (CR + VGPR) compared to less than VGPR (9 versus 6.8 years; HR: 1.5, P = 0.04 [95% CI: 1–2.1]) at renal transplantation. Median graft survival was 7.8 years and was better in the CR + VGPR group (8.3 vs 5.7 years, HR: 1.4, P = 0.05 [95% CI: 1–2]). The frequency and time to amyloid recurrence in the graft was also lower (16% vs 37%, p = 0.01) and longer (median time not achieved vs 10 years, p = 0.001) in the CR + VGPR group. Comparing CR vs. VGPR there was no difference in overall or graft survival. Although 69 patients (29%) experienced hematologic relapse, treatment effectively prevented graft loss in the majority (87%). Renal transplantation in selected AL amyloidosis patients is associated with extended overall and renal graft survival. Patients with hematologic CR or VGPR have the most favorable outcomes, and these patients should be considered for renal transplantation.
Exosomal miR-155-5p derived from glioma stem-like cells promotes mesenchymal transition via targeting ACOT12
Authors: Bao Zixu , Zhang Ning , Niu Wanxiang , Mu Maolin , Zhang Xiaoming , Hu Shanshan , Niu Chaoshi 
Published: August 2022

AbstractTumor-associated exosomes play essential roles in intercellular communication and the foundation of cancer microenvironment in glioma. Many mRNAs, microRNAs (miRNAs) and proteins contained in tumor-associated exosomes can be transferred to recipient cells and contribute to the progression of tumor. Nevertheless, the cellular communication between malignant cells with different heterogeneities or characteristics and resultant tumor progression are still unclear in glioma. Here, we show that exosomes released from glioma stem-like cells (GSCs) contain a significant increasing level of miR-155-5p and could be horizontally transferred to surrounding glioma cells. High expression of miR-155-5p in plasma exosomes from patients was associated with glioma diagnosis and grading. Mechanically, we found that miR-155-5p markedly reduced the expression of acetyl-CoA thioesterase 12 (ACOT12), which played as a tumor suppressor in glioma. Furthermore, mesenchymal transition was significantly promoted in glioma cells treated with GSCs-derived exosomes. In conclusion, GSCs-derived exosomal miR-155-5p play a critical role in glioma progression and facilitating tumor aggressive growth by targeting ACOT12 and promoting mesenchymal transition. Exosomal miR-155-5p is also a potential predictive biomarker for glioma, which may provoke the development of novel diagnostic and therapeutic strategies against glioma.
Real picture of magnetic domain dynamics along the magnetic hysteresis curve inside an advanced permanent magnet
Authors: Takeuchi Makoto , Suzuki Motohiro , Kobayashi Shintaro , Kotani Yoshinori , Nakamura Tetsuya , Kikuchi Nobuaki , Bolyachkin Anton , Sepehri-Amin Hossein , Ohkubo Tadakatsu , Hono Kazuhiro , Une Yasuhiro , Okamoto Satoshi 
Published: August 2022

AbstractIn the long history of permanent magnet research for more than 100 years, three-dimensional magnetic microscopy has been eagerly awaited to elucidate the origin of the magnetic hysteresis of permanent magnets. In this study, we succeeded in observing the three-dimensional magnetic domain structure of an advanced high-coercivity Nd-Fe-B-based permanent magnet throughout the magnetic hysteresis curve using a recently developed hard X-ray magnetic tomography technique. Focused-ion-beam-based three-dimensional scanning electron microscopy was employed to study the relationship between the observed magnetic domains and the microstructure of the magnet for the same observing volume. Thermally demagnetized and coercivity states exhibit considerably different magnetic domain structures but show the same periodicity of 2.3 μm, indicating that the characteristic length of the magnetic domain is independent of the magnetization states. Further careful examination revealed some unexpected magnetic domain behaviors, such as running perpendicular to the magnetic easy axis and reversing back against the magnetic field. These findings demonstrate a wide variety of real magnetic domain behaviors along the magnetic hysteresis inside a permanent magnet.
Modelling the medium-term dynamics of SARS-CoV-2 transmission in England in the Omicron era
Authors: Barnard Rosanna C. , Davies Nicholas G. ,   Centre for Mathematical Modelling of Infectious Diseases COVID-19 working group, Munday James D. , Lowe Rachel , Knight Gwenan M. , Leclerc Quentin J. , Tully Damien C. , Hodgson David , Pung Rachael , Hellewell Joel , Koltai Mihaly , Simons David , Abbas Kaja , Kucharski Adam J. , Procter Simon R. , Sandmann Frank G. , Pearson Carl A. B. , Prem Kiesha , Showering Alicia , Meakin Sophie R. , O’Reilly Kathleen , McCarthy Ciara V. , Quaife Matthew , Wong Kerry L. M. , Jafari Yalda , Deol Arminder K. , Houben Rein M. G. J. , Diamond Charlie , Jombart Thibaut , Villabona-Arenas C. Julian , Waites William , Eggo Rosalind M. , Endo Akira , Gibbs Hamish P. , Klepac Petra , Williams Jack , Quilty Billy J. , Brady Oliver , Emery Jon C. , Atkins Katherine E. , Chapman Lloyd A. C. , Sherratt Katharine , Abbott Sam , Bosse Nikos I. , Mee Paul , Funk Sebastian , Lei Jiayao , Liu Yang , Flasche Stefan , Rudge James W. , Sun Fiona Yueqian , Medley Graham , Russell Timothy W. , Gimma Amy , Hué Stéphane , Jarvis Christopher I. , Finch Emilie , Clifford Samuel , Jit Mark , Edmunds W. John 
Published: August 2022

AbstractEngland has experienced a heavy burden of COVID-19, with multiple waves of SARS-CoV-2 transmission since early 2020 and high infection levels following the emergence and spread of Omicron variants since late 2021. In response to rising Omicron cases, booster vaccinations were accelerated and offered to all adults in England. Using a model fitted to more than 2 years of epidemiological data, we project potential dynamics of SARS-CoV-2 infections, hospital admissions and deaths in England to December 2022. We consider key uncertainties including future behavioural change and waning immunity and assess the effectiveness of booster vaccinations in mitigating SARS-CoV-2 disease burden between October 2021 and December 2022. If no new variants emerge, SARS-CoV-2 transmission is expected to decline, with low levels remaining in the coming months. The extent to which projected SARS-CoV-2 transmission resurges later in 2022 depends largely on assumptions around waning immunity and to some extent, behaviour, and seasonality.
Socially meaningful visual context either enhances or inhibits vocalisation processing in the macaque brain
Authors: Froesel Mathilda , Gacoin Maëva , Clavagnier Simon , Hauser Marc , Goudard Quentin , Ben Hamed Suliann 
Published: August 2022

AbstractSocial interactions rely on the interpretation of semantic and emotional information, often from multiple sensory modalities. Nonhuman primates send and receive auditory and visual communicative signals. However, the neural mechanisms underlying the association of visual and auditory information based on their common social meaning are unknown. Using heart rate estimates and functional neuroimaging, we show that in the lateral and superior temporal sulcus of the macaque monkey, neural responses are enhanced in response to species-specific vocalisations paired with a matching visual context, or when vocalisations follow, in time, visual information, but inhibited when vocalisation are incongruent with the visual context. For example, responses to affiliative vocalisations are enhanced when paired with affiliative contexts but inhibited when paired with aggressive or escape contexts. Overall, we propose that the identified neural network represents social meaning irrespective of sensory modality.