bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haematological and biochemical reference intervals in healthy Ragdoll cats
Authors: Ferriani Riccardo , Mangiagalli Giulia , Meazzi Sara , Pantoli Marianna , Barbè Federico , Pastore Camilla , Rossi Silvia 
Published: April 2022

Objectives Breed-specific reference intervals (RIs) may be necessary to avoid misinterpretation of laboratory results. The main aim of this study was to establish haematobiochemical RIs for Ragdoll cats. Methods Forty-two clinically healthy adult (0.8–10 years old) Ragdoll cats (Ragdoll population [RP]) and 60 non-Ragdoll cats as the control population (CP) were prospectively enrolled. Results of haematology, biochemistry and total thyroxine (TT4) were used to determine both Ragdoll-specific and general feline population RIs for each variable using Reference Value Advisor software according to the Clinical and Laboratory Standards Institute guidelines and the American Society of Veterinary Clinical Pathology guidelines. Results For each analyte, RIs of the RP were calculated and compared with those obtained from the CP. Haematocrit, haemoglobin, mean cell volume, mean cell haemoglobin concentration, reticulocyte absolute count, platelet count and lymphocyte absolute number were statistically different from the CP. Biochemistry RIs revealed a statistical difference in creatinine kinase (CK), total protein, urea, creatinine, glucose, total calcium and iron. Conclusions and relevance Haematobiochemical RIs of the general feline population must be used with caution in Ragdoll cats when it comes to iron and glucose concentrations, CK activity and absolute lymphocyte number. For these parameters, the use of breed-specific RIs is suggested. The docile and more relaxed nature of this breed may explain these differences and further investigations are necessary to better understand the results. Furthermore, investigations are needed to evaluate the possible benefits of breed-specific urea RIs.
Topical cenegermin 0.002% for pediatric neurotrophic keratopathy
Authors: Elhusseiny Abdelrahman M. , Traish Aisha S. , Saeed Hajirah N. , Mantagos Iason S. 
Published: April 2022

PurposeTo evaluate the efficacy and safety of cenegermin 0.002% ophthalmic drops in the management of pediatric neurotrophic keratopathy (NK).MethodsRetrospective chart review of children under the age of 18 years diagnosed with NK at Boston Children's Hospital/Massachusetts Eye and Ear Infirmary and treated with topical cenegermin 0.002% ophthalmic solution between June 2018 and June 2021 was performed. Data collection included etiology of NK, age at time of initiation of topical cenegermin, laterality, ethnicity, gender, history of previous ocular therapy, pre- and post-therapy best corrected visual acuity, pre- and post-therapy cornea examination, any adverse events from topical cenegermin, associated ocular conditions, and history of ocular surgeries.ResultsThe current study includes four eyes of four pediatric patients with a mean age of 4.5 ± 2.0 years at the time of initiation of topical cenegermin therapy. The mean time from NK diagnosis until start of topical cenegermin drops was 5.2 ± 4.3 months and mean follow-up time was 15 ± 9.6 months. In all four patients, marked improvement in epitheliopathy was demonstrated after completion of therapy. Best corrected visual acuity was measurable in 3 eyes of 3 patients, and it improved from a mean of 0.07 ± 0.01 to a mean of 0.29 ± 0.26 ( P = 0.3). No adverse events related to cenegermin therapy were noted.ConclusionTopical cenegermin was effective in improving corneal healing for pediatric NK.
A meta-analysis of visual outcomes and optical quality after small incision lenticule extraction versus implantable collamer lens for myopia
Authors: Di Yu , Cui Ge , Li Ying , Luo Yan 
Published: April 2022

Objective To evaluate possible differences in visual outcome and optical quality when small incision lenticule extraction (SMILE) versus implantable collamer lens (ICL) is used to correct myopia. Methods PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched up to August 2021 to identify relevant studies. The PRISMA guidelines were followed. Primary outcomes were postoperative efficacy, safety, and predictability at the end of follow-up. Secondary outcomes were changes in modulation transfer function cutoff frequency (MTF cut−off), objective scatter index (OSI) values, total higher-order aberrations (HOAs), spherical aberrations, and coma aberrations. Results Seven studies with a total of 1296 eyes (SMILE: 731 eyes; TECXL: 565 eyes) were included. The ICL group had a better MTF cut−off ( P = 0.007) and less change in the proportion of HOAs ( P < 0.001), spherical aberrations ( P = 0.009), and coma ( P = 0.006) than the SMILE group. For the other outcomes, there were no statistically significant differences. Conclusions SMILE and ICL implantation are comparable in efficacy, safety, and predictability for correcting myopia. Larger studies with longer follow-up times are warranted to provide a better understanding of the benefits of SMILE and ICL implantation.
Comparison of ultrasound guided dorsal radial artery cannulation and conventional radial artery cannulation at the volar aspect of wrist: A pilot randomized controlled trial
Authors: Maitra Souvik , Baidya Dalim K , Ray Bikash R , Chowhan Ganesh , Bhattacharjee Sulagna 
Published: April 2022

Background: Distal radial artery cannulation at the “anatomical snuffbox” carries several theoretical advantages over conventional radial arterial cannulation at the wrist. However, these two techniques have not been evaluated in perioperative settings. Methods: In this randomized controlled trial, n = 200 patients requiring arterial cannulation for perioperative monitoring were recruited. Patients were randomized to either ultrasound guided distal radial artery cannulation group (group D) or ultrasound guided conventional radial artery cannulation group (group W). Primary outcome of this study was first attempt cannulation success rate. Results: First attempt cannulation success rate was significantly lower in distal radial artery cannulation (57% in group D and 77% in group W; p = 0.003). Use of alternative cannulation site was significantly higher in group D when compared to group W ( p = 0.015) and number of attempts for successful cannulation was significantly higher in group D when compared to group W ( p = 0.015). None of the patients in any group developed thrombosis and related complications and intraoperative catheter dislodgement. Time to puncture the artery ( p < 0.0001), total cannulation time ( p < 0.0001), and actual catheter insertion time ( p < 0.0001) were significantly higher in group D in comparison to group W. Conclusion: Distal radial artery cannulation was associated with lower first attempt cannulation success rate and requires longer time to perform. As distal radial artery is a new technique, further studies are required in different clinical settings.
Population characteristics and source analysis of microorganisms in a regularly disinfected library
Authors: Zhang Ge , Li Yang , Song Zhangyu , Hao Yang 
Published: April 2022

This study investigated the impact of regular disinfection on the concentration of microbial aerosol and the distribution of microbial species in a university library and analysed the main sources of microorganisms. The microorganisms in the air were sampled by six-stage Andersen cascade impactors, and their diversity was explored based on ribosomal DNA site amplification and sequencing technology. The statistical analysis found that the average concentrations of bacteria and fungi in this library were 149 ± 36 CFU/m3 and 118 ± 33 CFU/m3, respectively. The concentration in the reading rooms, the hybrid rooms and the stack rooms decreased in succession. The disinfection effect was significant comparing the result with non-disinfected libraries reported in literature. The concentration ratio of indoor and outdoor microorganisms (I/O) was greater than 1, and the concentration of microbial aerosol was positively correlated with the concentration of CO2 and particulate matter. The results indicate that the microbial concentration was mainly from indoor occupants. The most prevalent microorganisms were Paenibacillus, Bacillus, Penicillium and Cladosporium. This species' distribution was not affected by disinfection measures. The median diameter of microbial aerosols in most rooms was less than 5 μm. The use of disinfectants did not affect the particle size distribution of microorganisms.
Dementia-friendly initiatives within the context of COVID-19 pandemic: Challenges and strategies perceived by service professional stakeholders from the USA and China
Authors: Sun Fei , Opur Fredrika A , Kim Ha-Neul , Prieto Lucas R , Conyers Christian 
Published: April 2022

Purposes Dementia-friendly initiatives (DFI) are community-based movements aimed to address stigma, exclusion, and discrimination associated with dementia. This study examined the challenges faced and strategies used by DFI prior to and during the COVID-19 pandemic from the perspectives of stakeholders in the USA and China. Methods Qualitative interviews with 17 stakeholders involved in DFI from the United States and mainland China were conducted via the Zoom platform. Semi-structured interview questions focused on DFI challenges and strategies prior to and during the pandemic. Thematic analysis was used to analyze the data. Results Three major challenges prior to the COVID-19 pandemic included low participation of persons with dementia, difficulties in building community collaborations, and limited funding and resources needed to sustain DFI. During the COVID-19 pandemic, challenges included exacerbated difficulties of involving persons with dementia and reduced policy support for DFI. Strategies implemented prior to COVID-19 included partnerships with community organizations to outreach and engage persons with dementia, and coordination of resources and diversification of funding sources to sustain DFI. Strategies during the COVID-19 pandemic centered on the implementation of person-centered technology to support persons with dementia and family caregivers, and the development of new programs that integrated efforts to address the impact of COVID-19. Implications DFI in the USA and mainland China shared similar challenges for DFI prior to and during COVID-19. During the COVID-19 pandemic, DFI in both countries showed resourcefulness through reliance on technology, community collaboration, and COVID-19–related resources to provide support and services. While it remains critical to advocate to the central government to fund DFI, DFI in both societies need to be open to other funding sources, hire persons with dementia as key staff members of DFI, and demonstrate its effectiveness through rigorous evaluation.
Midterm Outcomes of BeGraft Stent Grafts Used as Bridging Stents in Fenestrated Endovascular Aortic Aneurysm Repair
Authors: Clough Rachel E. , Spear Rafaëlle , Mougin Justine , Le Houérou Thomas , Fabre Dominique , Sobocinski Jonathan , Haulon Stéphan 
Published: April 2022

Purpose: Fenestrated endovascular aneurysm repair (fEVAR) is established for the treatment of juxtarenal, pararenal, and thoracoabdominal aortic aneurysms (TAAAs). Bridging stents are used to connect the main body of the stent graft to the aortic branch vessels. Complications related to the bridging stents compromise the durability of the repair and require urgent re-intervention. Here we present the midterm results of the BeGraft stent graft system used for fEVAR. Materials and method: All consecutive patients treated with fEVAR and the current BeGraft Peripheral Stent Graft between November 2015 and September 2016 were included. Results: Thirty-nine consecutive patients (38 men) were enrolled and 101 BeGraft second-generation stent grafts were implanted. The median aneurysm diameter was 60 mm (54.5–67.0 mm). Aneurysms were juxtarenal and pararenal (19/39, 48.1%), type 4 TAAA (3/39, 7.7%), type 1, 2, and 3 TAAA (7/39, 17.8%), type 5 TAAA (4/39, 10.2%), and 15.4% (6/39) had a type I endoleak following a previous EVAR. Fifty-five BeGrafts were implanted in mesenteric arteries (22 in coeliac trunks, 31 in the superior mesenteric artery, and 2 in a hepatic or splenic artery) and 46 into renal arteries (24 right and 22 left). The renal artery diameters were 5, 6, 7, and 8 mm in 9, 7, 26, and 4 patients, respectively. Mesenteric arteries were exclusively stented with 9 and 10 mm diameter devices. The median follow-up was 33 months (IQ25 17–IQ75 36). During follow-up, 11 patients died (28%) from non–aneurysm-related causes. The overall patency rates for bridging stents were 98% and 97% at 1 and 2 years, respectively, with a freedom from secondary procedure rate on BeGraft stent grafts of 96% (97/101). All events occurred on stents implanted in renal arteries. Conclusion: Early favorable outcomes are confirmed during longer term follow-up. Vigilant surveillance is required.
Flexible carbon nanofiber yarn electrodes for self-standing fiber supercapacitors
Authors: Altin Yasin , Celik Bedeloglu Ayse 
Published: April 2022

In this study, polyacrylonitrile (PAN) nanofiber yarns were obtained by twisting the nanofiber mat strips produced in the electrospinning device. On the drum collector, the nanofibers are produced in such a way that the diameter change can be controlled. Through stabilization and carbonization processes, PAN nanofiber yarns were converted to carbon nanofiber (CNF) yarns. The stabilization process stabilized the yarn structure, which was previously unstable, due to thermal treatments. The obtained CNF yarn had a diameter of approximately 360 μm and an average nanofiber diameter of 123 ± 20 nm. On a three-electrode system, the electrochemical performance of CNF yarn in 1 m H2SO4 electrolyte was determined using cyclic voltammetry and galvanostatic charge/discharge test methods. The specific capacitance of the CNF yarn electrode was determined to be 145 F/g at a current density of 0.2 A/g. Up to 500 charge/discharge cycles, the specific capacitance increased by approximately 20% and remained constant thereafter. Due to their superior properties such as high surface area, lightweight, and flexibility, CNF yarn electrodes can be used in a wide variety of electronic applications, including energy harvesting, energy storage (supercapacitors, batteries, etc.), and sensors.
Evaluation of Remodeling of Visceral Arteries and Impact on Renal Function Post-endovascular Repair of Type B Aortic Dissection Vis-A-Vis Baseline Visceral Artery Morphology
Authors: Deshpande Amit Ajit , Pandey Niraj Nirmal , Shaw Manish , Kumar Sanjeev , Jagia Priya , Choudhary Shiv 
Published: April 2022

Purpose To evaluate the remodeling of visceral arteries post-endovascular repair (TEVAR) of type B aortic dissection and to investigate interval change in renal volume and estimated glomerular filtration rate (eGFR) vis-a-vis baseline visceral artery morphology. Materials and Methods All patients of type B aortic dissection who underwent TEVAR with a baseline and follow-up CT during the study period were included. Baseline morphology of visceral arteries (celiac, superior, and inferior mesenteric artery and bilateral renal artery) were classified into 7 patterns depending upon the origin of the artery (from true/false lumen) and the extension of dissection flap, while occluded vessels were categorized as pattern 8. Results One hundred and thirty-two branches were analyzed in 25 patients (23 males; mean age: 50.1 years) with a mean follow-up of 386 days. 51 visceral branches were arising from the true lumen without any stenosis. Of the remaining 81 branches, 48 showed favorable remodeling ( P = .0001). The highest incidence of favorable remodeling was observed in arteries arising from the true lumen (pattern 2,3: 44/48; 91.6%) whereas only one thrombosed and artery arising from the false lumen each (pattern 5 and 8) showed favorable remodeling. Kidneys perfused by false lumen or occluded renal artery suffered statistically significant volume loss compared to kidneys perfused by true or both lumens (−16.5% vs .2%; P = .01); however, the change in eGFR failed to reach statistical significance. Conclusion Visceral arteries arising from the true lumen are more likely to undergo favorable remodeling. The kidneys supplied by false lumen or by occluded renal artery suffer significantly more volume loss after TEVAR.
An individualised psychosocial intervention program for persons with MND/ALS and their families in low resource settings
Authors: Thomas Priya Treesa , Warrier Manjusha G , Arun S , Bhuvaneshwari B , Vengalil Seena , Nashi Saraswati , Preethish-Kumar Veeramani , Polavarapu Kiran , Rajaram Prakashi , Nalini Atchayaram 
Published: April 2022

Motor Neuron Disease (MND) leads to significant psychosocial distress for the person with the illness and caregivers. Psychosocial factors influence the management and quality of life to a significant degree. Objective To develop individualised psychosocial intervention program for people with MND and their families in India. Methods People with MND and healthcare staff were constructively involved in co-designing the intervention program in four phases adapted from the MRC framework: 1. A detailed need assessment phase where 30 participants shared their perceptions of psychosocial needs 2. Developing the intervention module (synthesis of narrative review, identified needs); 3. Feasibility testing of the intervention program among seven participants; 4. Feedback from participants on the feasibility (acceptance, practicality adaptation). The study adopted an exploratory research design. Results Intervention program of nine sessions, addressing psychosocial challenges through the different stages of progression of the illness and ways to handle the challenges, specific to the low resource settings, was developed and was found to be feasible. People with MND and families who participated in the feasibility study shared the perceived benefit through feedback interviews. Conclusion MND has changing needs and challenges. Intervention programme was found to be feasible to be implemented among larger group to establish efficacy.
COVID-19 Infection in Patients with Humoral Immunodeficiency: A Case Series and Literature Review
Authors: Jalil Maaz , Pietras Julianne , Ahmed Syed N. , Daniels Phuong , Hostoffer Robert 
Published: April 2022

Background The coronavirus 2019 disease (COVID-19) has infected many individuals worldwide and continues to pose a significant threat to those with weakened immune systems. The data evaluating the clinical outcomes of patients with humoral immunodeficiencies that contract COVID-19 is limited and conflicting. Objective To describe the clinical outcomes of COVID-19 infections in patients with primary humoral immunodeficiency and compare results to current literature. Methods We conducted a retrospective cohort review on 15 patients with a humoral immunodeficiency defined as Common Variable Immunodeficiency, Specific Antibody Deficiency, or unspecified hypogammaglobulinemia, who contracted COVID-19. Severity scores were determined to evaluate the clinical outcomes of these patients. Results Of our 15-patient cohort, 33% of individuals with a humoral immunodeficiency infected with COVID-19 had moderate to severe disease, requiring hospitalization or resulting in death. COVID-19 mortality rate was found to be 7%. All 5 of our patients with severe COVID-19 infection had at least 1 comorbidity or risk factor. Conclusion Within our cohort of humoral immunodeficient patients infected with COVID-19, we found a higher rate of moderate to severe COVID-19 infection and worse clinical outcomes, particularly in patients with comorbidities or risk factors.
Evaluating the Chase Utley Rule: The Association Between a Rule Change and Collision-Related Injuries in Major League Baseball
Authors: Tanenbaum Joseph E. , Knapik Derrick M. , Karns Michael R. , Salata Michael J. , Gillespie Robert J. , Voos James E. 
Published: April 2022

Background: Major League Baseball (MLB) adopted a rule change in 2016 to reduce the number of collisions that occur when a player slides into a base. The effect of rule 6.01(j) has not been quantified, and it remains unknown if this rule change has led to improved player safety. Hypothesis: Rule 6.01(j) would be associated with a reduction in the number of collision-related injuries at second base. Study Design: Cohort study; Level of evidence, 3. Methods: Using data from the MLB Health and Injury Tracking System, we quantified the number of collision-related injuries for defensive (ie, fielding) players in the infield at the major and minor league levels between the 2010 and 2019 seasons. We compared the median number of collision-related injuries for defensive players in the infield from before (2010-2015) to after (2016-2019) the implementation of rule 6.01(j) and also calculated the difference in location of the median from the seasons before versus after the rule change. An additional 3 analyses were performed to support or contradict a conclusion that any observed reduction in injuries at the start of the 2016 season was likely caused by the adoption of rule 6.01(j). Results: The median number of collision-related injuries for defensive players at second base decreased from 58.5 to 37.5 injuries per season after the rule change, which was a 36% decrease (difference in location, 19.5 [95% CI, 5.0 to 31.0]; P = .019). In contrast, the median number of collision-related injuries at first base decreased by only 14.1%, from 49.5 before to 42.5 after the rule change (difference in location, –9.0 [95% CI, –4.0 to 18.0]; P = .16), and the median number of collision-related injuries per season at third base was unchanged at 15 per season. Conclusion: This rule change was associated with a decrease in the number of collision-related injuries, with the largest effect observed at second base, as expected.
Role of stem cell transplant in CD30+ PTCL following frontline brentuximab vedotin plus CHP or CHOP in ECHELON-2
Authors: Savage Kerry J. , Horwitz Steven M. , Advani Ranjana , Christensen Jacob Haaber , Domingo-Domenech Eva , Rossi Giuseppe , Morschhauser Franck , Alpdogan Onder , Suh Cheolwon , Tobinai Kensei , Shustov Andrei , Trneny Marek , Yuen Sam , Zinzani Pier Luigi , Trümper Lorenz , Ilidge Tim , O’Connor Owen A. , Pro Barbara , Miao Harry , Bunn Veronica , Fenton Keenan , Fanale Michelle , Puhlmann Markus , Iyer Swaminathan 
Published: April 2022

Abstract
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of aggressive non-Hodgkin lymphomas, the majority of which have high relapse rates following standard therapy. Despite use of consolidative stem cell transplant (SCT) following frontline therapy, there remains no consensus on its utility. The double-blind randomized phase 3 ECHELON-2 study (#NCT01777152; clinicaltrials.gov) demonstrated improved progression-free survival (PFS) and overall survival with frontline brentuximab vedotin plus cyclophosphamide, doxorubicin, and prednisone (A+CHP). Herein, we conducted an exploratory subgroups analysis of the impact of consolidative SCT on PFS in patients with previously untreated CD30+ PTCL (ALK− anaplastic large cell lymphoma [ALCL] and non-ALCL) who were in complete response (CR) after frontline treatment with A+CHP or cyclophosphamide, doxorubicin, vincristine, and prednisone. Median PFS follow-up was 47.57 months. The PFS hazard ratio was 0.36, equating to a 64% reduction in the risk of a PFS event in patients who underwent SCT. The median PFS in patients who underwent SCT was not reached, vs 55.66 months in patients who did not undergo SCT. PFS results favored the use of SCT in both ALK− ALCL and non-ALCL subgroups. These data support the consideration of consolidative SCT in patients with CD30+PTCL who achieve CR following treatment with A+CHP.