bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intersectoral and intercountry linkages as drivers of employment growth in emerging economies: The case of Visegrád countries
Authors: Di Berardino Claudio , Doganieri Ilaria , D'Angelo Stefano , Onesti Gianni 
Published: August 2022

AbstractThis study provides new empirical evidence on the transformation of the structure of production in the Visegrád (V4) countries—the Czech Republic, Hungary, Poland, and Slovakia—using a multi‐regional version of the subsystem approach to global input‐output tables. In particular, the paper analyses structural change in these countries, with a focus on the integration of market services in manufacturing. Moreover, using an input‐output structural decomposition analysis (SDA), we evaluate the role of some key determinants of employment changes in manufacturing. The results indicate that an increasing amount of intermediate demand comes from producer services. Further, a substantial portion of manufacturing employment is generated by foreign final demand, and the SDA demonstrates that labour intensity and final demand play a determining role in the change in the number of hours worked.
Claudin targeting as an effective tool for directed barrier modulation of the viable epidermis
Authors: Beier Laura‐Sophie , Waldow Ayk , Khomeijani Farahani Saeed , Mannweiler Roman , Vidal‐Y‐Sy Sabine , Brandner Johanna M. , Piontek Jörg , Günzel Dorothee 
Published: August 2022

AbstractTight junction (TJ) formation is vital for epidermal barrier function. We aimed to specifically manipulate TJ barriers in the reconstructed human epidermis (RHE) by claudin‐1 and ‐4 knockdown (KD) and by claudin‐binding fusion proteins of glutathione S‐transferase and modified C‐terminal fragments of Clostridium perfringens enterotoxin (GST‐cCPE). Impedance spectroscopy and tracer permeability imaging were employed for functional barrier assessment and investigation of claudin contribution. KD of claudin‐1, but not claudin‐4, impaired the paracellular barrier in vitro. Similarly, claudin‐binding GST‐cCPE variants weakened the paracellular but not the stratum corneum barrier. Combining both TJ targeting methods, we found that claudin‐1 targeting by GST‐cCPE after claudin‐4 KD led to a marked decrease in paracellular barrier properties. Conversely, after claudin‐1 KD, GST‐cCPE did not further impair the barrier. Comparison of GST‐cCPE variants with different claudin‐1/claudin‐4 affinities, NHS‐fluorescein tracer detection, and immunostaining of RHE paraffin sections showed that GST‐cCPE variants bind to extrajunctional claudin‐1 and ‐4, which are differentially distributed along the stratum basale–stratum granulosum axis. GST‐cCPE binding blocks these claudins, thereby specifically opening the paracellular barrier of RHE. The data indicate a critical role for claudin‐1 in regulating paracellular permeability for ions and small molecules in the viable epidermis. Claudin targeting is presented as a proof‐of‐concept for precise barrier modulation.
FE UPTAKE‐INDUCING PEPTIDE1 maintains Fe translocation by controlling Fe deficiency response genes in the vascular tissue of Arabidopsis
Authors: Okada Satoshi , Lei Gui J. , Yamaji Naoki , Huang Sheng , Ma Jian F. , Mochida Keiichi , Hirayama Takashi 
Published: August 2022

AbstractFE UPTAKE‐INDUCING PEPTIDE1 (FEP1), also named IRON MAN3 (IMA3) is a short peptide involved in the iron deficiency response in Arabidopsis thaliana. Recent studies uncovered its molecular function, but its physiological function in the systemic Fe response is not fully understood. To explore the physiological function of FEP1 in iron homoeostasis, we performed a transcriptome analysis using the FEP1 loss‐of‐function mutant fep1‐1 and a transgenic line with oestrogen‐inducible expression of FEP1. We determined that FEP1 specifically regulates several iron deficiency‐responsive genes, indicating that FEP1 participates in iron translocation rather than iron uptake in roots. The iron concentration in xylem sap under iron‐deficient conditions was lower in the fep1‐1 mutant and higher in FEP1‐induced transgenic plants compared with the wild type (WT). Perls staining revealed a greater accumulation of iron in the cortex of fep1‐1 roots than in the WT root cortex, although total iron levels in roots were comparable in the two genotypes. Moreover, the fep1‐1 mutation partially suppressed the iron overaccumulation phenotype in the leaves of the oligopeptide transporter3‐2 (opt3‐2) mutant. These data suggest that FEP1 plays a pivotal role in iron movement and in maintaining the iron quota in vascular tissues in Arabidopsis.
Assessing the export trade risk of bluetongue virus serotypes 4 and 8 in France
Authors: Zhang Shuwen , Zhang Qiang , Zhang Hui , Liang Ruirui , Chen Qin , Niu Bing 
Published: August 2022

AbstractBluetongue (BT) causes an economic loss of $3 billion every year in the world. After two serious occurrences of BT (bluetongue virus [BTV] occurrence in 2006 and 2015), France has been controlling for decades, but it has not been eradicated. As the largest live cattle export market in the world, France is also one of the major exporters of breeding animals and genetic materials in the world. The biosafety of its exported cattle and products has always been a concern. The scenario tree quantitative model was used to analyze the risk of BTV release from French exported live cattle and bovine semen. The results showed that with the increase in vaccination coverage rates, the risk decreased. If the vaccine coverage is 0%, the areas with the highest average risk probability of BTV‐4 and BTV‐8 release from exported live cattle were Haute‐Savoie and Puy‐de‐Dôme, and the risk was 2.96 × 10–4 and 4.25 × 10–4, respectively. When the vaccine coverage was 90%, the risk probability of BTV‐4 and BTV‐8 release from exported live cattle was 2.96 × 10–5 and 4.24 × 10–5, respectively. The average probability of BTV‐8 release from bovine semen was 1.09 × 10–10. Sensitivity analysis showed that the probability of false negative polymerase chain reaction (PCR) test and the probability of BT infection in the bull breeding station had an impact on the model. The identification of high‐risk areas and the discovery of key control measures provide a reference for decision makers to assess the risk of French exports of live cattle and bovine semen.
Epidemiology and outcomes of surgical site infections among pediatric liver transplant recipients
Authors: Banach David B. , Lopez‐Verdugo Fidel , Sanchez‐Garcia Jorge , Tran Alexandria , Gomez‐Llerena Adriana , Munoz‐Abraham Armando Salim , Bertacco Alessandra , Valentino Pamela L. , Yoo Peter , Dembry Louise‐Marie , Mulligan David C. , Ekong Udeme D. , Emre Sukru H. , Rodriguez‐Davalos Manuel I. 
Published: August 2022

AbstractIntroductionSurgical site infections (SSI) are a significant cause of morbidity in liver transplant recipients, and the current data in the pediatric population are limited. The goal of this study was to identify the incidence, classification, risk factors, and outcomes of SSIs among children undergoing liver transplantation (LT).MethodsA single‐center, retrospective descriptive analysis was performed of patients age ≤18 years undergoing LT between September 2007 and April 2017. SSI identified within the first 30 days were analyzed. Primary endpoints included incidence, classification, risk factors, and outcomes associated with SSIs.ResultsWe included 86 patients, eight patients (9.3%) developed SSIs. Among segmental grafts (SG) recipients, 7/61 (11.4%) developed SSI. Among whole grafts recipients, 1/25 (4%) developed SSI. SSIs were associated with the presence of biliary complications (35% vs. 3%, p < .01; odds ratios 24, 95% CI: 3.41‐487.37, p<.01). There were no differences in long term graft or patient survival associated with SSI. Patients who developed SSI were more likely to undergo reoperation (50% vs. 16.7%, p = .045) and had an increased total number of hospital days in the first 60 days post‐transplant (30.5 vs. 12.5 days, p = .001).ConclusionsSSIs after pediatric LT was less frequent than what has been previously reported in literature. SSIs were associated with the presence of biliary complications without an increase in mortality. SG had an increased rate of biliary complications without an association to SSIs but, considering its positive impact on organ shortage barriers, should not be a deterrent to the utilization of SGs.image
Impact of the COVID-19 pandemic on maternity services in Europe: a mixed methods systematic review protocol
Authors: Thorn-Cole Harriet , De Labrusse Claire , Abderhalden-Zellweger Alessia , Kaech Christelle , Hammer Raphaël 
Published: August 2022

ABSTRACT

Objective:
This review will synthesize and integrate the best available evidence on the changes caused by the COVID-19 pandemic in access to and the provision of maternity services in Europe. The review will also consider health care professionals’ experiences in providing maternity care during the COVID-19 pandemic in Europe.

Introduction:
Governments and maternity services have introduced various protective sanitary and organizational measures to reduce the spread of COVID-19 and protect the global population, including health care professionals. Since March 2020, the number of publications on this topic has soared, yet little is known about the effect of the pandemic and the accompanying measures on access to and the provision of maternity care in Europe.

Inclusion criteria:
The review will consider quantitative, qualitative, and mixed methods studies on the impact of COVID-19 on European maternity services. For the quantitative component, the review will consider studies evaluating maternity services outcomes across all types of maternity care settings. For the qualitative component, the review will consider studies exploring maternity health care providers’ experiences and perceptions of the impact of the pandemic on care provided to women and their babies.

Methods:
Six bibliographic databases will be searched for published and unpublished studies since March 2020. Study selection, critical appraisal, data extraction, and data synthesis will follow JBI's segregated mixed methods approach. The quantitative component will be adapted to follow the JBI requirements for systematic reviews of etiology and risk.

Systematic review registration number:
PROSPERO CRD42021283878
Work and oxygen consumption of isolated right ventricular papillary muscle in experimental pulmonary hypertension
Authors: van der Laarse Willem J. , Bogaards Sylvia J. P. , Schalij Ingrid , Vonk Noordegraaf Anton , Vaz Frédéric M. , van Groen Duncan 
Published: August 2022

AbstractRight‐sided myocardial mechanical efficiency (work output/metabolic energy input) in pulmonary hypertension can be severely reduced. We determined the contribution of intrinsic myocardial determinants of efficiency using papillary muscle preparations from monocrotaline‐induced pulmonary hypertensive (MCT‐PH) rats. The hypothesis tested was that efficiency is reduced by mitochondrial dysfunction in addition to increased activation heat reported previously. Right ventricular muscle preparations were subjected to 5 Hz sinusoidal length changes at 37°C. Work and suprabasal oxygen consumption () were measured before and after cross‐bridge inhibition by blebbistatin. Cytosolic cytochrome c concentration, myocyte cross‐sectional area, proton permeability of the inner mitochondrial membrane and monoamine oxidase and glucose 6‐phosphate dehydrogenase activities and phosphatidylglycerol/cardiolipin contents were determined. Mechanical efficiency ranged from 23% to 11% in control (n = 6) and from 22% to 1% in MCT‐PH (n = 15) and correlated with work (r2 = 0.68, P < 0.0001) but not with (r2 = 0.004, P = 0.7919). for cross‐bridge cycling was proportional to work (r2 = 0.56, P = 0.0005). Blebbistatin‐resistant (r2 = 0.32, P = 0.0167) and proton permeability of the mitochondrial inner membrane (r2 = 0.36, P = 0.0110) correlated inversely with efficiency. Together, these variables explained the variance of efficiency (coefficient of multiple determination r2 = 0.79, P = 0.0001). Cytosolic cytochrome c correlated inversely with work (r2 = 0.28, P = 0.0391), but not with efficiency (r2 = 0.20, P = 0.0867). Glucose 6‐phosphate dehydrogenase, monoamine oxidase and phosphatidylglycerol/cardiolipin increased in the right ventricular wall of MCT‐PH but did not correlate with efficiency. Reduced myocardial efficiency in MCT‐PH is a result of activation processes and mitochondrial dysfunction. The variance of work and the ratio of activation heat reported previously and blebbistatin‐resistant are discussed.
imageKey points
Mechanical efficiency of right ventricular myocardium is reduced in pulmonary hypertension. Increased energy use for activation processes has been demonstrated previously, but the contribution of mitochondrial dysfunction is unknown.
Work and oxygen consumption are determined during work loops. Oxygen consumption for activation and cross‐bridge cycling confirm the previous heat measurements.
Cytosolic cytochrome c concentration, proton permeability of the mitochondrial inner membrane and phosphatidylglycerol/cardiolipin are increased in experimental pulmonary hypertension.
Reduced work and mechanical efficiency are related to mitochondrial dysfunction.
Upregulation of the pentose phosphate pathway and a potential gap in the energy balance suggest mitochondrial dysfunction in right ventricular overload is a resiult of the excessive production of reactive oxygen species.
La problemática de la enfermedad crónica en población trabajadora: una revisión de revisiones
Authors: Palencia-Sánchez Francisco , Riaño-Casallas Martha Isabel 
Published: August 2022

La transición demográfica y epidemiológica ha llevado a un aumento de la prevalencia de las enfermedades crónicas (EC) que no solamente afecta a la población por encima de los 65 años sino también a la población en edad económicamente activa. El propósito de este estudio es analizar cómo ha sido el abordaje de la EC en la población trabajadora desde los modelos presentados por Arredondo, en Salud Pública (SP).
Se realizó una búsqueda sistemática documentos tipo revisiones de la literatura en base de datos indexadas y motores de búsqueda durante el periodo 2006-2019, excluyendo estudios únicamente enfocados en la relación exposición-efecto o al manejo clínico de la EC. Para la evaluación de la calidad de los estudios incluidos se utilizó el instrumento AMSTAR.
Se hizo un análisis de cómo se ha abordado la problemática de la EC en la población trabajadora, desde los modelos en SP, lo que transciende el enfoque clásico biomédico. En particular evidenciando que el abordaje de esta problemática debe ir más allá de los estilos de vida, hábitos nutricionales, y la necesidad de profundizar su estudio en el contexto latinoamericano.
Tumores de células germinales intracraneales: aspectos básicos, abordaje diagnóstico y alternativas terapéuticas
Authors: Marchán Cárdenas Juan Camilo , Visbal Spirko Lila Piedad , Acosta Fernández Sinforoso Alfonso 
Published: August 2022

Introducción: Los Tumores de células germinales son neoplasias originadas por precursores de los gametos que, por defectos en procesos embriológicos migratorios, pueden aparecer en órganos extragonadales como el Encéfalo, donde constituyen un grupo variado y cada vez más frecuente de tumores. Objetivo: Exponer información relevante y actualizada sobre los procesos genéticos, fisiopatológicos y clínicos de los Tumores de células germinales intracraneales.
Materiales y métodos: Búsqueda sistematizada de publicaciones científicas, mediante la estrategia PICO, en bases de datos electrónicas. Conclusiones: Los tumores de células germinales intracraneales se clasifican en Germinoma y tumores de células germinales no germinomatosas. Dichos subgrupos representan una gran paradoja, ya que, pese a tener un origen común, son muy distintos entre sí. Los cambios genéticos que sustentan la génesis de ambos tumores son completamente opuestos: los Germinomas se caracterizan por presentar hipometilación del ADN y los no germinomas hipermetilación. Histológicamente, los tumores no germinomatosos muestran células menos diferenciadas con alta tasa mitótica, lo que les confiere mal pronóstico, contrario al Germinoma, que por sus características citológicas es menos agresivo. El diagnóstico supone la medición de Biomarcadores, que suelen ser negativos para el germinoma y positivos para los no germinomas; las neuroimágenes no ofrecen mayor información diferencial, y la confirmación es histológica. El tratamiento atiende al pronóstico, por ello será más impetuoso para los tumores no germinomatosos.
Universal Solution Manifold Networks (USM-Nets): Non-Intrusive Mesh-Free Surrogate Models for Problems in Variable Domains
Authors: Regazzoni Francesco , Pagani Stefano , Quarteroni Alfio 
Published: August 2022

Abstract
We introduce universal solution manifold network (USM-Net), a novel surrogate model, based on artificial neural networks (ANNs), which applies to differential problems whose solution depends on physical and geometrical parameters. We employ a mesh-less architecture, thus overcoming the limitations associated with image segmentation and mesh generation required by traditional discretization methods. Our method encodes geometrical variability through scalar landmarks, such as coordinates of points of interest. In biomedical applications, these landmarks can be inexpensively processed from clinical images. We present proof-of-concept results obtained with a data-driven loss function based on simulation data. Nonetheless, our framework is non-intrusive and modular, as we can modify the loss by considering additional constraints, thus leveraging available physical knowledge. Our approach also accommodates a universal coordinate system, which supports the USM-Net in learning the correspondence between points belonging to different geometries, boosting prediction accuracy on unobserved geometries. Finally, we present two numerical test cases in computational fluid dynamics involving variable Reynolds numbers as well as computational domains of variable shape. The results show that our method allows for inexpensive but accurate approximations of velocity and pressure, avoiding computationally expensive image segmentation, mesh generation, or re-training for every new instance of physical parameters and shape of the domain.
Parallelized Element-By-Element Solver for Structural Analysis of Flexible Pipes Using Finite Macroelements
Authors: Toni Fernando Geremias , de Arruda Martins Clóvis 
Published: August 2022

Abstract
Due to the number of layers and their respective geometrical complexities, finite element analyses of flexible pipes usually require large-scale schemes with a high number of elements and degrees-of-freedom. If proper precautions are not taken, such as suitable algorithms and numerical methods, the computational costs of these analyses may become unfeasible. Finite macroelements are finite elements formulated for the solution of a specific problem considering and taking advantage of its particularities, such as geometry patterns, to obtain computational advantages, as reduced number of degrees-of-freedom and ease of problem description. The element-by-element (EBE) method also fits very well in this context, since it is characterized by the elimination of the global stiffness matrix and its memory consumption grows linearly with the number of elements, besides being highly parallelizable. Over the last decades, several works regarding the EBE method were published in the literature, but none of them directly applied to flexible pipes. Due to the contact elements between the layers, problems with flexible pipes are usually characterized by very large matrix bandwidth, making the implementation of the EBE method more challenging, so that its efficiency and scalability are not compromised. Therefore, this work presents a parallelized implementation of an element-by-element architecture for structural analysis of flexible pipes using finite macroelements. Four synchronization algorithms were developed and analyzed in detail, including their scalability assessment, and comparisons were made with a well-established finite element method (FEM) software with significant gains in simulation time and memory consumption.
Comparative Study of the Flow-Induced Vibration of a Circular Cylinder Attached With Front and/or Rear Splitter Plates at a Low Reynolds Number of 120
Authors: Tang Tao , Zhu Hongjun , Li Guomin , Song Jinze 
Published: August 2022

Abstract
This paper numerically investigates the flow-induced vibration of a circular cylinder attached with front and/or rear splitter plates at a low Reynolds number of Re = 120. The effects of plate length and plate location on the hydrodynamic coefficient, vibration response, and flow wake are examined and discussed in detail. The results reveal that the hydrodynamic coefficient of the cylinder with a single rear plate is significantly reduced at Ur ≤ 8 (Ur is the reduced velocity), resulting in the vortex-induced vibration (VIV) suppression. Nevertheless, the galloping is excited at Ur &gt; 8 due to the hydrodynamic instability, accompanied by the jump of response amplitude and hydrodynamic force, as well as the abrupt drop of response frequency. The alternate reattachment of shear layers on the plate surface introduces an extra lift force that strengthens the vibration response. By introducing an individual front plate, significant VIV suppression is achieved. The vibration exhibits variable patterns when the cylinder is equipped with bilateral plates, including the typical VIV mode, weak VIV-galloping coupling mode, and IB-galloping-DB mode (IB and DB represent the initial branch and desynchronization branch of VIV, respectively). The galloping branch in IB-galloping-DB mode is observed with an abrupt drop in response frequency, as well as a tiny time lag between the displacement and lift force. The vibration response is significantly suppressed when the cylinder is simultaneously equipped with a 1D front plate and a 1–2D rear plate due to the streamlined profile.
Optimization of the Steam Alternating Solvent Process Using Pareto-Based Multi-Objective Evolutionary Algorithms
Authors: Mayo-Molina Israel , Leung Juliana Y. 
Published: August 2022

Abstract
Steam alternating solvent (SAS) process has been proposed as a more environmentally friendly alternative to traditional steam-based processes for heavy oil production. It consists of injecting steam and a non-condensable gas (solvent) alternatively to reduce the oil viscosity. However, optimizing multiple process design (decision) variables is not trivial since multiple conflicting objectives (i.e., maximize the recovery factor, reduce steam–oil ratio) must be considered. Three different multi-objective evolutionary algorithms (MOEAs) are employed to identify a set of Pareto-optimal operational parameters. A multi-objective optimization (MOO) workflow is developed: first, a 2D reservoir model is constructed based on the Fort McMurray formation. Second, a sensitivity analysis is performed to identify the most impactful decision parameters. Third, two response surface (proxy) models and three different MOEAs are employed and compared. This paper is the first to compare different MOEAs for optimizing a wide range of operational parameters for the SAS process. The results show that if more steam is injected, extending the steam cycle duration is preferable. Conversely, if more solvent is injected, it is recommended to start with injecting a solvent with high propane concentrations over short cycles and switch to lower propane concentrations over long cycles near the end.