bluuebunny/crossref_metadata_2025_split huggingface dataset:
International College of Person Centered Medicine
Authors: Mezzich Juan 
Published: September 2022

Table of Contents
Prologue: James Appleyard and Juan Mezzich
SECTION 1: General Concepts and Program Organization
Introduction to Section 1. Jim Appleyard and Juan E. Mezzich
1.1 Person Centered Medicine Foundations for Medical Education: Juan Mezzich, Ihsan Salloum, Levent Kirisci, Alberto Perales
1.2 Medical Professionalism and Ethical and Human Rights Foundations of Person Centered Medicine: Jon Snaedal
1.3 The Making of a Physician: A Person-centered Approach: Shridhar Sharma, Gautam Sharma
1.4 Concepts and Strategies of People-Centered Public Health: Fredy A. Canchihuaman, James Appleyard, Juan Mezzich

SECTION 2: Communication, Common Ground, Diagnosis, and Assessment
Introduction to Section 2. James Appleyard and Juan E. Mezzich
2.1 Clinical Communication and Empathy: Michel Botbol
2.2 Setting a Common Ground for Collaborative Care and Clinical Interviewing: Juan Mezzich
2.3 Person-centered Integrative Diagnosis: Concepts and procedures: Ihsan Salloum and Juan Mezzich
2.4 Continuity and Integration of Person Centered Assessment and Care across the Lifecycle: James Appleyard and Michel Botbol

SECTION 3: Care Planning, Shared Decision-Making and Inter-Professional Collaboration
Introduction to Section 3. James Appleyard and Juan E. Mezzich
3.1 Person-centered Care Planning and Shared Decision-making for Mental and Comorbid Conditions: Helen Millar
3.2 Shared Decision Making in Oncology and Palliative Care: Paul Glare
3.3 Shared Decision Making for Other General Conditions: James Appleyard and Jon Snaedal
3.4 Inter-professional Collaboration: Tesfa Ghebrehiwet

SECTION 4: Foundations and Horizons
Introduction to Section 4. Juan E. Mezzich and Michael Wong
4.1 Médecine de la Personne: Tournier’s vision and legacy: John Cox and James Appleyard
4.2 The Science of Well-being: The physical, mental, and spiritual aspects of health are inseparable: C. Robert Cloninger
4.3 Mental Health Promotion: Person-Centered Perspective: George N. Christodoulou
4.4 Culture in Person- and People-Centered Health Care: Werdie Van Staden
4.5 Spirituality and Person-Centered Health Care: John Cox
The Impacts of a Smoking Ban on Gaming Volume in a South Korea Casino
Authors: Lee Sojeong , Repetti Toni , Singh Ashok K. , Bernhard Bo 
Published: September 2022

The number of countries and cities implementing smoking bans has increased significantly over the last couple decades with smoking bans becoming more inclusive with less exemptions being given. Casinos though still have an exemption in most areas since there is uncertainty of the effect to gaming volume but there is a new call to action due to COVID-19. This study evaluates the long-term effects of a smoking ban in Kangwon Land Casino in South Korea. A time series ARIMA model for April 2003 to May 2013 was conducted to determine if the new smoking ban in public gaming areas significantly affected table games drop or slot coin-in, which are the two most common indicators of gaming volume for casinos. Results show that the smoking ban did not significantly impact table games drop or slot coin-in. The results of this study indicate that in the long-term a smoking ban in public areas does not significantly decrease gaming volume. These results add to the minimal studies on the long-term effects of a smoking ban while also being the first study to evaluate an Asian casino.
A escrita enquanto inferno:
Authors: Papke Isabela Padilha 
Published: September 2022

O presente trabalho, tem por objetivo, realizar uma análise da crônica “Sem um braço no inferno”, presente no livro, A bagagem do viajante (2017), do autor português, José Saramago, através do uso conceito de ironia enquanto reconhecimento da impotência do sujeito por si mesmo, cunhado por Gyorgy Lukács, em sua obra Teoria do Romance (2009). Nossa intenção, portanto, parte do pressuposto de revelar o como, o autor, faz o uso desta figura de linguagem, para representar o descontentamento do sujeito protagonista mediante ao caráter finito da vida humana, fazendo uso de uma margem alegórica de interpretação do conceito, de modo a incorporar a ironia enquanto personagem em sua ficção.
Juanita’s Paintings: A Manager’s Personal Ethics and Performance Reviews
Authors: Boyd Melanie 
Published: September 2022

It’s 10:30 in the morning. David, a reference librarian at Norringwood Library, leaves his desk and walks to his supervisor Juanita’s office. The door is open. David looks at Juanita, who has just settled into one of the easy chairs next to the window. She lifts a carafe of coffee from the side table and pours herself a cup. As Juanita sips her coffee, gazing out the window at the street traffic below, David pauses quietly
in the doorway and looks around Juanita’s office—a place he’s been dozens of times.
Library Development: A Long-Term Strategy for Library Funding
Authors: Cervone Frank 
Published: September 2022

Compared with other areas of library management, library development has received little attention in the library literature. Many of the important works related to development were written more than a decade ago. In the last decade, only two major works related to the topic have been published: an issue of Library Trends (Winter 2000) devoted to development and fundraising, primarily in the academic environment, and an updated version of Steele
and Elder’s Becoming a Fundraiser. This is especially significant in a time of economic downturn.
A Journey towards Sustainability: Viewing the Information Literacy Network of the Gulf Region through the Lens of P.M. Senge.
Authors: Birks Jane , Eula Isabelle 
Published: September 2022

This paper explores issues in developing, leading and sustaining a professional development organization in the Gulf region.
Launched in December 2005, the Information Literacy Network (ILN) of the Gulf Region is an organization of librarians which supports and encourages student learning in higher education. The ILN aims to provide its members with opportunities to discuss best practices and regional challenges to developing instructional programs in information literacy.
The authors outline their experience highlighting the stages of development, accomplishments and recurrent challenges of the ILN. They draw parallels between the ILN and effective ‘learning organizations’ as defined by P.M. Senge in his book “The Fifth Discipline: The Art and Practice of the Learning Organization” . The authors in their dual roles as managers and leaders reflect on the application of Senge’s framework to the ILN to identify appropriate strategies and propose a set of recommendations to ensure that the continued development of the ILN as a true learning organization.
From Zero to Sixty in Under One Year: A Practical Approach to Building New Programs and Services, Managing Change, and Embracing Innovation as a New Library Administrator
Authors: Ippoliti Cinthya 
Published: September 2022

New library administrators face several challenges as they tackle bringing change into an existing environment or creating something new. The current literature examines trends within higher education, but there is a scarcity of practical information to assist emerging leaders in balancing managerial duties with effectuating long-term progress within the cultural and political landscapes of their institutions.

This case study seeks to help first-time administrators grapple with issues such as:
•	Engaging in effective supervisory and mentorship activities while advancing broader strategic directions
•	Building partnerships both internal and external to the library
•	Measuring the impact of initiatives in relation to institutional priorities
DDX17 modulates the expression and alternative splicing of genes involved in apoptosis and proliferation in lung adenocarcinoma cells
Authors: He Cheng , Zhang Gan , Lu Yanhong , Zhou Jingyue , Ren Zixue 
Published: September 2022

Background
The DEAD-box RNA-binding protein (RBP) DDX17 has been found to be involved in the tumorigenesis of many types of cancers. However, the role of DDX17 in lung adenocarcinoma (LUAD) remains unclear.

Methods
We silenced DDX17 expression in A549 LUAD cells by small interfering RNA (siRNA). Cell proliferation and apoptosis assays were performed to explore the functions of DDX17. Knockdown of DDX17 by siRNA significantly inhibited proliferation and induced apoptosis in A549 cells. We used high-throughput RNA sequencing (RNA-seq) to identify differentially expressed genes (DEGs) and alternative splicing (AS) events in DDX17 knockdown LUAD cells.

Results
DDX17 knockdown increased the expression levels of proapoptotic genes and decreased those of proproliferative genes. Moreover, the DDX17-regulated AS events in A549 cells revealed by computational analysis using ABLas software were strongly validated by quantitative reverse transcription–polymerase chain reaction (RT–qPCR) and were also validated by analysis of The Cancer Genome Atlas (TCGA)-LUAD dataset. These findings suggest that DDX17 may function as an oncogene by regulating both the expression and AS of proliferation- and apoptosis-associated genes in LUAD cells. Our findings may offer new insights into understanding the molecular mechanisms of LUAD and provide a new therapeutic direction for LUAD.
Inhibitory Effect of Gedunin Analogue against the Plasmodium falciparum Dihydrofolate Reductase
Authors: Arazu V. Amarachukwu , Nelson Christian , Henrietta Uzoeto O. , Akinwonmi Ayodele , Ochepo A. Solomon , Samuel Cosmas 
Published: September 2022

Objective: Plasmodium parasites are the cause of malaria. Malaria victims get infected upon being bitten by female anopheles mosquito; which transmits the parasite to the victim. The P. falciparum and P. vivax are the most active disease-causing agents of all five malaria-causing species of Plasmodium. The anti-folate drugs which were the first class of clinical antimetabolites act by disrupting metabolic pathways in which the one-carbon moiety supplied by the B9 folate vitamins is a major requirement.
Methods: Chemical structures of the anti-folate drugs which served as the experimental control ligands were downloaded from the PubChem database and saved as PDB files while the gedunin modification was achieved using the Marvin-Sketch software.
Results: Molecular visualization of the polar interactions with amino acid residues of the Plasmodium falciparum dihydrofolate-reductase showed that all the control ligands interacted with similar residues contrary to the interaction of the gedunin modified ligand in the same binding pocket.
Conclusion: Results from the molecular docking study showed that gedunin and its C=O of gedunin might be better antimalarial agents; having exhibited the best binding energies with a score of -9.5 and -9.0 Kcal/mol respectively.
Impacts of Telehealth on Access-to-Care for Mental Health Patients
Authors: Hernandez Jennings 
Published: September 2022

The age of technology and smart devices has paved the way for a current and encouraging method to address mental healthcare that benefits from global connectivity: telehealth. According to the American Telemedicine Association, telehealth or telemedicine is defined as the usage of medical information from one site to another through electronic communication with the goal of improving a client’s overall health through emails, cellular phones, two-way videos, and conference calls. With the current Covid-19 pandemic, hospitals (especially those with mental health units or free-standing psychiatry facilities) are seldomly able to keep up with the influx of mental health patients without being turned away or having to wait for an extended period of time. Through telemedicine, those barriers have been lifted providing more efficient and enhanced access to care for everyone, especially those seeking mental health services. This review paper attempts to establish that despite the observations that telehealth has a positive impact on improved access to mental healthcare, it has not flourished to the extent it could have prior to the COVID-19 pandemic. We also try to provide long-term telehealth solutions, some of which are already being implemented in the current pandemic to improve the quality of mental healthcare access to a larger majority of Americans and those in other countries as well. With people being advised to stay-at-home coupled with the fear of cross-contamination in public places, people are resorting to telehealth for psychiatric visits and follow-ups. Before this pandemic, however, certain laws and rules have been a barrier to more telehealth options becoming available or feasible to the public. Telehealth is changing the conventional standard of psychiatric medicine by enhancing access to care, reducing re-admission rates, and enhancing the quality of life. Those that have tested positive for the COVID-19 virus and are quarantined at home can still meet with their mental healthcare provider periodically to discuss progress and prognosis. Research has shown that telemedicine has neutralized the impacts of delayed care, hospital admissions, and complications from psychiatric conditions globally. Telehealth has proven to provide steady benefits to patients, psychiatrists, and mental health providers through round-the-clock access remotely.
Fluorescence Resonance Energy Transfer Based Biosensor from Thermophilic Bacterial Periplasmic Binding Protein to Measure Branched-chain and Aromatic Amino Acids
Authors: Kabir Md. Mohiuddin , Imam Md. Rayhan , Hossain Chowdhury Faiz , Sultana Gazi Nurun Nahar 
Published: September 2022

Aim: Exploring the ligand binding capacity of leucine-isoleucine-valine binding protein from Thermotoga maritima.
Background: The Fischer ratio, ratio of concentrations between branched-chain and aromatic amino acids, has been considered as an indicator of hepatic disease involving metabolic dysfunctions since its instigation in the 1970's. These amino acids are usually measured by high performance liquid chromatography, gas chromatography and enzymatic spectrophotometry. Considering the future potential of periplasmic binding proteins in clinical diagnosis, leucine-isoleucine-valine binding protein from a thermophilic bacterium Thermotoga maritima was purified and characterized, and evaluated its binding properties with twenty amino acids. The protein's stereo-specificity was also tested due to its importance in astrobiology research. Amino acids and carbohydrates are both known to exist in extraterrestrial environments, and stereo-chemistry is the key aspect for distinguishing between abiotic and biotic origin.
Results: Single amino acid substitutions were generated by overlapping polymerase chain reaction mediated mutagenesis using mutagenic primers to construct two mutants of leucine-isoleucine-valine binding protein (LIVBP). The first mutant of LIVBP in which phenylalanine (F) at 118 position was replaced with cysteine (C) was termed as LIVBP-F118C and the resultant plasmid was named as pKM242. Another mutant of LIVBP in which aspartic acid (D) at 221 position was replaced with cysteine was termed as LIVBP-D221C and the resultant plasmid was named as pKM244. Since the LIVBP-F118C showed higher labeling and fluorescence resonance energy transfer efficiency compared to that of D221C, the LIVBP-F118C was used for further study.
Conclusion: Fluorescence resonance energy transfer technology was applied to measure dissociation constant (Kd) where chimeric isoleucine-valine binding protein (LIVBP) was engineered to conjugate a donor fluorophore at amino-terminal and an acceptor fluorophore at the incorporated cysteine residue. Ligand binding studies revealed that LIVBP from Thermotoga maritima was able to bind with fourteen amino acids out of twenty including branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) with Kd values ranging from 10-6 to 10-9 M. The Kd values of BCAAs, AAAs, methionine and cysteine were observed at nM level. Highest Kd value was observed for L-leucine (37.2 nM) and L-phenylalanine (44.6 nM). These results indicated that LIVBP from Thermotoga maritima has a broader substrate specificity than previously reported for LIVBP from other organisms, which might be helpful for the development of a miniaturized and noninvasive biosensor to measure BCAAs and AAAs.
Estimating the Prevalence of Substance Use Disorders in the US Using the Benchmark Multiplier Method
Authors: Mojtabai Ramin 
Published: September 2022

ImportancePrevalence estimates of substance use disorders in the US rely on general population surveys. However, major population groups, such as homeless individuals and institutionalized individuals, are not captured by these surveys, and participants may underreport substance use.ObjectiveTo estimate the prevalence of substance use disorders in the US.Design, Setting, and ParticipantsThe benchmark multiplier method was used to estimate the prevalence of alcohol, cannabis, opioid, and stimulant use disorders based on data from the Transformed Medicaid Statistical Information System (T-MSIS) (the benchmark) and the National Survey on Drug Use and Health (NSDUH) (the multiplier) for 2018 and 2019. T-MSIS collects administrative data on Medicaid beneficiaries 12 years and older with full or comprehensive benefits. NSDUH is a nationally representative annual cross-sectional survey of people 12 years and older. Data were analyzed from February to June 2022.Main Outcomes and MeasuresPrevalence of substance use disorders was estimated using the benchmark multiplier method based on T-MSIS and NSDUH data. Confidence intervals for the multiplier method estimates were computed using Monte Carlo simulations. Sensitivity of prevalence estimates to variations in multiplier values was assessed.ResultsThis study included Medicaid beneficiaries 12 years and older accessing treatment services in the past year with diagnoses of alcohol (n = 1 017 308 in 2018; n = 1 041 357 in 2019), cannabis (n = 643 737; n = 644 780), opioid (n = 1 406 455; n = 1 575 219), and stimulant (n = 610 858; n = 657 305) use disorders and NSDUH participants with 12-month DSM-IV alcohol (n = 3390 in 2018; n = 3363 in 2019), cannabis (n = 1426; n = 1604), opioid (n = 448; n = 369), and stimulant (n = 545; n = 559) use disorders. The benchmark multiplier prevalence estimates were higher than NSDUH estimates for every type of substance use disorder in both years and in the combined 2018 to 2019 sample: 20.27% (95% CI, 17.04-24.71) vs 5.34% (95% CI, 5.10-5.58), respectively, for alcohol; 7.57% (95% CI, 5.96-9.93) vs 1.68% (95% CI, 1.59-1.79) for cannabis; 3.46% (95% CI, 2.97-4.12) vs 0.68% (0.60-0.78) for opioid; and 1.91% (95% CI, 1.63-2.30) vs 0.85% (95% CI, 0.75-0.96) for stimulant use disorders. In sensitivity analyses, the differences between the benchmark multiplier method and NSDUH estimates persisted over a wide range of potential multiplier values.Conclusions and RelevanceThe findings in this study reflect a higher national prevalence of substance use disorders than that represented by NSDUH estimates, suggesting a greater burden of these conditions in the US.
A Novel Approach to Assessment of US Pediatric Trauma System Development
Authors: Fallat Mary E. , Treager Colin , Humphrey Sophie , Gumer Lindsey , Jawad Kahir , Butler Elissa , Rogers Frederick B. , Rivara Frederick P. , Collings Amelia T. 
Published: September 2022

ImportanceMature trauma systems are critical in building and maintaining national, state, and local resilience against all-hazard disasters. Currently, pediatric state trauma system plans are not standardized and thus are without concrete measures of potential effectiveness.ObjectiveTo develop objective measures of pediatric trauma system capability at the state level, hypothesizing significant variation in capabilities between states, and to provide a contemporary report on the status of national pediatric trauma system planning and development.Design, Setting, and ParticipantsA national survey was deployed in 2018 to perform a gap analysis of state pediatric trauma system capabilities. Four officials from each state were asked to complete the survey regarding extensive pediatric-related or specific trauma system parameters. Using these parameters, a panel of 14 individuals representing national stakeholder sectors in pediatric trauma care convened to identify the essential components of the ideal pediatric trauma system using Delphi methodology. Data analysis was conducted from March 16, 2019, to February 23, 2020.Main Outcomes and MeasuresBased on results from the national survey and consensus panel parameters, each state was given a composite score. The score was validated using US Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) fatal injury database.ResultsThe national survey had less than 10% missing data. The consensus panel reached agreement on 6 major domains of pediatric trauma systems (disaster, legislation/funding, access to care, injury prevention/recognition, quality improvement, pediatric readiness) and was used to develop the Pediatric Trauma System Assessment Score (PTSAS) based on 100 points. There was substantial variation across states, with state scores ranging from 48.5 to 100. Based on US CDC WONDER data, for every 1-point increase in PTSAS, there was a 0.12 per 100 000 decrease in mortality (95% CI, −0.22 to −0.02; P = .03).Conclusions and RelevanceResults of this cross-sectional study suggest that a more robust pediatric trauma system has a significant association with pediatric injury mortality. This study assessed the national landscape of capability and preparedness to provide pediatric trauma care at the state level. These parameters can tailor the maturation of children’s interests within a state trauma system and assist with future state, regional, and national planning.
Stable Sodium‐Metal Batteries in Carbonate Electrolytes Achieved by Bifunctional, Sustainable Separators with Tailored Alignment
Authors: Wang Jing , Xu Zhen , Zhang Qicheng , Song Xin , Lu Xuekun , Zhang Zhenyu , Onyianta Amaka J. , Wang Mengnan , Titirici Maria‐Magdalena , Eichhorn Stephen J. 
Published: September 2022

AbstractSodium (Na) is the most appealing alternative to lithium as an anode material for cost‐effective, high‐energy‐density energy‐storage systems by virtue of its high theoretical capacity and abundance as a resource. However, the uncontrolled growth of Na dendrites and the limited cell cycle life impede the large‐scale practical implementation of Na‐metal batteries (SMBs) in commonly used and low‐cost carbonate electrolytes. Herein, the employment of a novel bifunctional electrospun nanofibrous separator comprising well‐ordered, uniaxially aligned arrays, and abundant sodiophilic functional groups is presented for SMBs. By tailoring the alignment degree, this unique separator integrates with the merits of serving as highly aligned ion‐redistributors to self‐orientate/homogenize the flux of Na‐ions from a chemical molecule level and physically suppressing Na dendrite puncture at a mechanical structure level. Remarkably, unprecedented long‐term cycling performances at high current densities (≥1000 h at 1 and 3 mA cm−2, ≥700 h at 5 mA cm−2) of symmetric cells are achieved in additive‐free carbonate electrolytes. Moreover, the corresponding sodium–organic battery demonstrates a high energy density and prolonged cyclability over 1000 cycles. This work opens up a new and facile avenue for the development of stable, low‐cost, and safe‐credible SMBs, which could be readily extended to other alkali‐metal batteries.