bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tailoring Two Chemometric Models for Determination of Three Neuromuscular Combined Medications and Application to Spiked Human Plasma
Authors: Abdelhamid Nessreen S , Farid Nehal F , Anwar Basma H , Magdy Maimana A 
Published: November 2022

Abstract

Background
Prednisolone, 6-mercaptopurine, and pyridostigmine bromide are co-administered together to treat a neuromuscular autoimmune disease called myasthenia gravis. Prednisolone and 6-mercaptopurine are immunosuppressant drugs. 6-Mercaptopurine is the active form of the pro-drug azathioprine. Pyridostigmine bromide is a cholinesterase enzyme inhibitor. Curently, green characteristics are taken into account by analysts when they develop new methods.

Objective
The spectra of the three compounds and plasma are highly overlapped, so this study aims to remove this overlap and determine the three components quantitatively in raw powders and spiked human plasma using green methods.

Methods
Two multivariate updated chemometric models called principle component analysis and partial least-squares were developed. Three greenness assessment tools: the eco-scale, the analytical greenness metric approach, and the green analytical method index, were used to evaluate the greenness behavior of the generated models.

Results
The two models were verified in accordance with Food and Drug Administration requirements, and the results were within acceptable limits. In addition they are relatively green in accordance with the abovementioned greenness evaluation tools.

Conclusion
The developed models succeeded in determining the proposed drugs in their tertiary combinations and spiked human plasma with satisfactory precision, accuracy, and good greenness behavior.

Highlights
Two ecologically evaluated, multivariate spectrophotometric methods were developed for the determination of pyridostigmine bromide, 6-mercaptopurine, and prednisolone in spiked human plasma.
Minimal Rickettsial Infection Rates and Distribution of Ticks in Uganda: An Assessment of the Seasonal Effects and Relevance to Tick-Borne Disease Risk in East Africa
Authors: Corrigan James , Marion Brianna , English James , Eneku Wilfred , Weng Ju Lin , Rugg Molly , Dotrang Thoai , Dunford James , Byaruhanga Anatol M , Byarugaba Denis K , Ramalho-Ortigao Marcelo , Wanja Elizabeth W 
Published: November 2022

Abstract
Tick-borne diseases (TBDs) pose a significant risk to humans and represent one of the major factors influencing readiness within the United States’ military worldwide. Additionally, ticks and TBDs constitute major animal health problems leading to economic losses at multiple levels affecting low- and middle-income countries the hardest. Tick control is frequently hampered by issues ranging from acaricide resistance to lack of data on tick distribution and infection rates. We conducted a cross-sectional study to assess tick species distribution, host use, and rickettsial pathogen infection rate of ticks in different areas of the Uganda Cattle Corridor. We identified 4,425 hard ticks (Ixodida: Ixodidae) comprised of seven species by morphological characters with 3,315 ticks collected from four locations during the dry season and 1,110 ticks from one location during the wet season. Rickettsial pathogen prevalence was assessed in ticks collected from two districts to determine the minimum infection rate compared across seasons, village location, and tick species. We found statistically significant differences in the abundance and distribution of tick species among districts in the dry season, host animal species, and the proportion of rickettsial positive pools between villages. Seasonality, village location, and tick species do not affect the minimum infection rate of rickettsial pathogens of ticks in Uganda, but village location affects the proportion of positive tick pools. These results indicate geographical and seasonal differences among pathogen-harboring ticks contributing to our understanding of the current distribution of ticks and TBDs in Uganda.
Complexity function and complexity of validity of modal and superintuitionistic propositional logics
Authors: Rybakov Mikhail , Shkatov Dmitry 
Published: November 2022

Abstract
We consider the relationship between the algorithmic properties of the validity problem for a modal or superintuitionistic propositional logic and the size of the smallest Kripke countermodels for non-theorems of the logic. We establish the existence, for every degree of unsolvability, of a propositional logic whose validity problem belongs to the degree and whose every non-theorem is refuted on a Kripke frame that validates the logic and has the size linear in the length of the non-theorem. Such logics are obtained among the normal extensions of the propositional modal logics $\textbf {KTB}$, $\textbf {GL}$ and $\textbf {Grz}$ as well as in the lattice of superintuitionistic propositional logics. This shows that the computational complexity of a modal or superintuitionistic propositional logic is, in general, not related to the size of the countermodels for its non-theorems.
Theory of Planned Behavior and Active Duty Air Force Members’ Mental Health Help-Seeking
Authors: Engelhardt Ethan C , Bicknell Graeme , Oliver Mark , Flaherty Chris , Line Katelynn , King Erika 
Published: November 2022

ABSTRACT

Introduction
Although military members often encounter significant atypical stressors while serving, many service members are still reluctant to seek mental health (MH) treatment. Help-seeking behavior for MH needs is a rising concern for active duty Air Force personnel. Conditions such as post-traumatic stress disorder, depression, anxiety, and substance abuse are just a few issues that military members deal with, but things like stigma, attitudes toward MH, and behavioral control might keep these individuals from seeking services. This study utilizes the theory of planned behavior (TPB) to identify better and understand barriers to the help-seeking behavior of active duty Air Force members.

Materials and Methods
The 2017 Air Force Community Feedback Tool was used for this study. This confidential survey was completed by a large sample of the military population (N = 10,705). The survey was used to examine relationships between the TPB-related variables and respondents with mood problems identifying a need for professional counseling, seeking MH services, and reporting that the services met their needs. Multiple linear and binary logistic regression models were utilized to analyze findings from this sample.

Results
This study highlights how attitudes, subjective norms, and perceived behavioral control impact help-seeking behavior for these individuals. Findings include the MH providers’ good reputations, wait times for services, ease of access to care, and negative experiences with supervisor permission, all of which showed a statistically significant impact on help-seeking behavior. Dependent variables included “I need professional counseling,” “I contacted a MH care provider in the past year to try to meet this need,” and “How much the MH care provider helped you meet your needs.” Each of these variables had statistically significant relationships with the connecting variables of the TPB.

Conclusions
Findings from this study reveal how attitudes, subjective norms, and perceived behavioral control play an essential role in an active duty Air Force member’s decision to seek help for MH concerns. This study suggests that active duty military members are less concerned about the belief that seeking MH care could harm their reputations and more aware of the potential negative reputations of MH clinics. Finally, actionable steps are outlined to better support help-seeking behavior, which might be recommended to better train and encourage military leaders to address the MH needs of themselves and the members of their units.
Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization
Authors: Jeong Soo Lim , Zhang Hongyu , Yamaki Shanni , Yang Chenyu , McKemy David D , Lieber Michael R , Pham Phuong , Goodman Myron F 
Published: November 2022

AbstractWe describe a purified biochemical system to produce monoclonal antibodies (Abs) in vitro using activation-induced deoxycytidine deaminase (AID) and DNA polymerase η (Polη) to diversify immunoglobulin variable gene (IgV) libraries within a phage display format. AID and Polη function during B-cell affinity maturation by catalyzing somatic hypermutation (SHM) of immunoglobulin variable genes (IgV) to generate high-affinity Abs. The IgV mutational motif specificities observed in vivo are conserved in vitro. IgV mutations occurred in antibody complementary determining regions (CDRs) and less frequently in framework (FW) regions. A unique feature of our system is the use of AID and Polη to perform repetitive affinity maturation on libraries reconstructed from a preceding selection step. We have obtained scFv Abs against human glucagon-like peptide-1 receptor (GLP-1R), a target in the treatment of type 2 diabetes, and VHH nanobodies targeting Fatty Acid Amide Hydrolase (FAAH), involved in chronic pain, and artemin, a neurotropic factor that regulates cold pain. A round of in vitro affinity maturation typically resulted in a 2- to 4-fold enhancement in Ab-Ag binding, demonstrating the utility of the system. We tested one of the affinity matured nanobodies and found that it reduced injury-induced cold pain in a mouse model.
UBE2T promotes breast cancer tumor growth by suppressing DNA replication stress
Authors: Dutta Roshan , Guruvaiah Praveen , Reddi Kiran Kumar , Bugide Suresh , Reddy Bandi Dhana Sekhar , Edwards Yvonne J K , Singh Kamaljeet , Gupta Romi 
Published: November 2022

Abstract
Breast cancer is a leading cause of cancer-related deaths among women, and current therapies benefit only a subset of these patients. Here, we show that ubiquitin-conjugating enzyme E2T (UBE2T) is overexpressed in patient-derived breast cancer samples, and UBE2T overexpression predicts poor prognosis. We demonstrate that the transcription factor AP-2 alpha (TFAP2A) is necessary for the overexpression of UBE2T in breast cancer cells, and UBE2T inhibition suppresses breast cancer tumor growth in cell culture and in mice. RNA sequencing analysis identified interferon alpha–inducible protein 6 (IFI6) as a key downstream mediator of UBE2T function in breast cancer cells. Consistently, UBE2T inhibition downregulated IFI6 expression, promoting DNA replication stress, cell cycle arrest, and apoptosis and suppressing breast cancer cell growth. Breast cancer cells with IFI6 inhibition displayed similar phenotypes as those with UBE2T inhibition, and ectopic IFI6 expression in UBE2T-knockdown breast cancer cells prevented DNA replication stress and apoptosis and partly restored breast cancer cell growth. Furthermore, UBE2T inhibition enhanced the growth-suppressive effects of DNA replication stress inducers. Taken together, our study identifies UBE2T as a facilitator of breast cancer tumor growth and provide a rationale for targeting UBE2T for breast cancer therapies.
Laser hyperthermia: Past, present, and future
Authors: Schupper Alexander J , Chanenchuk Tori , Racanelli Anna , Price Gabrielle , Hadjipanayis Constantinos G 
Published: November 2022

Abstract
Magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) is an ablative procedure using heat from a laser to provide cytoreduction in tissue. It is a minimally invasive procedure that has been used in intracranial pathologies such as high-grade gliomas, metastatic lesions, epilepsy, and other lesions. While LITT may offer a more acceptable complication profile compared to open surgery, the role of laser therapy for intracranial lesions in current treatment paradigms continues to evolve. This review will focus on the background and application of LITT, the current evidence for its use, and future directions for the technology.
Risk Factors for Severe Coronavirus Disease 2019 Among Human Immunodeficiency Virus-Infected and -Uninfected Individuals in South Africa, April 2020–March 2022: Data From Sentinel Surveillance
Authors: Walaza Sibongile , Tempia Stefano , von Gottberg Anne , Wolter Nicole , Bhiman Jinal N , Buys Amelia , Amoako Daniel , Moosa Fahima , du Plessis Mignon , Moyes Jocelyn , McMorrow Meredith L , Dawood Halima , Variava Ebrahim , Reubenson Gary , Nel Jeremy , Zar Heather J , Makhasi Mvuyo , Meiring Susan , Quan Vanessa , Cohen Cheryl 
Published: November 2022

Abstract

Background
Data on risk factors for coronavirus disease 2019 (COVID-19)-associated hospitalization and mortality in high human immunodeficiency virus (HIV) prevalence settings are limited.

Methods
Using existing syndromic surveillance programs for influenza-like-illness and severe respiratory illness at sentinel sites in South Africa, we identified factors associated with COVID-19 hospitalization and mortality.

Results
From April 2020 through March 2022, severe acute respiratory syndrome coronavirus 2 was detected in 24.0% (660 of 2746) of outpatient and 32.5% (2282 of 7025) of inpatient cases. Factors associated with COVID-19-associated hospitalization included the following: older age (25–44 [adjusted odds ratio {aOR}= 1.8, 95% confidence interval (CI) = 1.1–2.9], 45–64 [aOR = 6.8, 95% CI = 4.2–11.0] and ≥65 years [aOR = 26.6, 95% CI = 14.4–49.1] vs 15–24 years); black race (aOR, 3.3; 95% CI, 2.2–5.0); obesity (aOR, 2.3; 95% CI, 1.4–3.9); asthma (aOR, 3.5; 95% CI, 1.4–8.9); diabetes mellitus (aOR, 5.3; 95% CI, 3.1–9.3); HIV with CD4 ≥200/mm3 (aOR, 1.5; 95% CI, 1.1–2.2) and CD4 &lt;200/mm3 (aOR, 10.5; 95% CI, 5.1–21.6) or tuberculosis (aOR, 12.8; 95% CI, 2.8–58.5). Infection with Beta (aOR, 0.5; 95% CI, .3–.7) vs Delta variant and being fully vaccinated (aOR, 0.1; 95% CI, .1–.3) were less associated with COVID-19 hospitalization. In-hospital mortality was increased in older age (45–64 years [aOR, 2.2; 95% CI, 1.6–3.2] and ≥65 years [aOR, 4.0; 95% CI, 2.8–5.8] vs 25–44 years) and male sex (aOR, 1.3; 95% CI, 1.0–1.6) and was lower in Omicron-infected (aOR, 0.3; 95% CI, .2–.6) vs Delta-infected individuals.

Conclusions
Active syndromic surveillance encompassing clinical, laboratory, and genomic data identified setting-specific risk factors associated with COVID-19 severity that will inform prioritization of COVID-19 vaccine distribution. Elderly people with tuberculosis or people with HIV, especially severely immunosuppressed, should be prioritized for vaccination.
Health and Digital Technology Partnerships
Authors: Specker Sullivan Laura 
Published: November 2022

Abstract
Abstract: Digital technology companies are seeking out partnerships with medical institutions at an astounding rate. Those involved tout these partnerships as empowering consumers, driving innovation, and increasing efficiency. At the same time, ethical red flags have gone up over potential violations of patient privacy and unsanctioned use of data for non-medical purposes. While contract transparency is a core ethical concern when personal health data is involved, a broader question is whether these contracts are different in kind than more established healthcare partnerships. Big data partnerships are relatively unique; these companies neither specialize in the healthcare industry nor provide healthcare institutions with an identifiable medical product. The ethical dimensions of these partnerships extend to broader questions about the appropriate role of digital technology corporations in an arena that, at least in theory, is oriented toward the physical, mental, and social well-being of everyone within our society.
The pattern of cortical thickness underlying disruptive behaviors in Alzheimer's disease
Authors: Xiong Raymond M , Xie Teng , Zhang Haifeng , Li Tao , Gong Gaolang , Yu Xin , He Yong 
Published: November 2022

Abstract

Background
Disruptive behaviors, including agitation, disinhibition, irritability, and aberrant motor behaviors, are commonly observed in patients with Alzheimer's disease (AD). However, the neuroanatomical basis of these disruptive behaviors is not fully understood.

Objective
To confirm the differences in cortical thickness and surface area between AD patients and healthy controls and to further investigate the features of cortical thickness and surface area associated with disruptive behaviors in patients with AD.

Methods
One hundred seventy-four participants (125 AD patients and 49 healthy controls) were recruited from memory clinics at the Peking University Institute of Sixth Hospital. Disruptive behaviors, including agitation/aggression, disinhibition, irritability/lability, and aberrant motor activity subdomain scores, were evaluated using the Neuropsychiatry Inventory. Both whole-brain vertex-based and region-of-interest-based cortical thickness and surface area analyses were automatically conducted with the CIVET pipeline based on structural magnetic resonance images. Both group-based statistical comparisons and brain-behavior association analyses were performed using general linear models, with age, sex, and education level as covariables.

Results
Compared with healthy controls, the AD patients exhibited widespread reduced cortical thickness, with the most significant thinning located in the medial and lateral temporal and parietal cortex, and smaller surface areas in the left fusiform and left inferior temporal gyrus. High total scores of disruptive behaviors were significantly associated with cortical thinning in several regions that are involved in sensorimotor processing, language, and expression functions. The total score of disruptive behaviors did not show significant associations with surface areas.

Conclusion
We highlight that disruptive behaviors in patients with AD are selectively associated with cortical thickness abnormalities in sensory, motor, and language regions, which provides insights into neuroanatomical substrates underlying disruptive behaviors. These findings could lead to sensory, motor, and communication interventions for alleviating disruptive behaviors in patients with AD.
Credit Environment and Small Business Dynamics: Evidence from Establishment-Level Data
Authors: Lin Chen , Tai Mingzhu , Xie Wensi 
Published: November 2022

AbstractWe evaluate how a positive, technology-driven shock to bank liquidity affects small business dynamics across different size distributions. We first show that banks receiving positive liquidity shocks increase lending to relatively larger SMEs, not to the smallest firms. This finding is consistent with the view that a positive liquidity shock enhances bank charter values, thereby reducing risk-taking incentives. Moreover, such disproportionate credit allocation leads to a crowding-out effect on micro firms. When larger SMEs grow faster and exit less because of better access to credit, their expansion stifles the development of micro firms, whose access to credit remains unchanged. (JEL G21, J21, L22)
Escaping Air Pollution: Immigrants, Students, and Spillover Effects on Property Prices Abroad
Authors: Chang Yuk Ying , Dasgupta Sudipto 
Published: November 2022

Abstract
We construct a time series of news coverage about air pollution in China for the period 1977–2019. Our measure of abnormal news coverage (ANC) of China’s air pollution is uncorrelated with growth in economic activity or cyclical components of such activity, but strongly correlated with weather-related and atmospheric conditions known to cause air pollution. ANC is associated with more capital flight from China. Focusing on the USA as a destination country, we find that ANC is associated with more Chinese citizens emigrating to US regions with stronger ethnic links to China, and more international students enrolling in US institutions with stronger Chinese student links. US regions with stronger ethnic or educational ties to China experience higher property price growth when ANC is higher. Our study suggests that perception of local environmental risk can have major consequences for the cross-border reallocation of capital and labor.
ANALYSES OF SOME CALL FACTORS AFFECTING SAR LEVELS OF GSM MOBILE PHONES USED IN GHANA
Authors: Osei S , Amoako J K , Sam F , Onyekwere P , Kudozia R Y 
Published: November 2022

Abstract
In response to mounting radiofrequency health concerns, this study was constituted to provide critical scientific data and assess any potential exposure from global system for mobile communication mobile phones. Specific absorption rate (SAR) from phones approved by the regulator and untested/unapproved phones were measured with a ComoSAR system. The maximum 10 g SAR (0.51 W/kg) and 1 g SAR (0.99 W/kg) measured were 25 and 62% of the International Commission on Non-Ionizing Radiation Protection and Federal Communication Commission limits, respectively. The approved phone produced statistically significant higher SAR values relative to the untested phone. SAR values of the right ear were relatively higher. All maximum SAR values were recorded on the right ear. The regulatory approval status of the phone, phone’s orientation to the head, operating frequency channel and in which ear (right or left) the phone is used influenced the SAR measured. The SAR values of the approved phone compared favourably with similar studies while the unapproved phone does not.
Assessment of effectiveness of deworming options in recently weaned beef cattle utilizing different anthelmintic programs in the southeast
Authors: Hernandez Shane R , Davis Dylan B , Credille Brent C , Tucker Jennifer J , Stewart Robert Lawton 
Published: November 2022

Abstract
This study evaluated the effects of three different anthelmintic strategies on animal performance and anthelmintic effectiveness in weaned calves during a 42-d preconditioning period. The study was conducted at four locations over 2 yr and included a total of 797 recently weaned spring-born calves (initial BW 260 ± 37.7 kg). At the start of each year, at each location, calves were weaned and randomly assigned to one of four treatments: 1) oxfendazole (ORAL); 2) transdermal eprinomectin (POUR); 3) both anthelmintic treatments (BOTH); and 4) the control (CONT) group who did not receive treatment. Anthelmintic was applied per the manufacturer recommendation, the transdermal eprinomectin was administered at 1 mL per 10 kg and oxfendazole was administered orally at 1 mL per 50 kg. Weights were measured at the start of the study (day 0) and again at the end of the preconditioning phase (day 42). Fecal samples were collected at the start of the study prior to treatment application (day 0) and again on day 14. Rumen fluid was collected at the start of the study prior to treatment (day 0) and again on day 6. There were treatment effects for all performance metrics (P &lt; 0.001). All treatments had greater weight gain and value of weight gained (P &lt; 0.024), and all three strategies did not differ from each other (P &gt; 0.420). On day 0, there were no (P = 0.795) treatment effects detected for fecal eggs per gram (EPG) counts. On day 14, there were (P &lt; 0.001) treatment effects for EPG counts with feces from CONT calves containing greater (P &lt; 0.014) EPG than feces from treated calves. EPG in feces from BOTH calves did not differ (P &gt; 0.123) from the other two treated groups and feces from POUR calves tended (P = 0.052) to contain greater EPG counts than feces from ORAL calves. Volatile fatty acids were similar across treatments on days 0 and 6 (P &gt; 0.115). Butyrate tended (P = 0.063) to be lower in ORAL on day 6. These results suggest that using eprinomectin and oxfendazole in combination was an effective strategy for reducing EPG and improving performance during a 42-d preconditioning phase.