bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Rotator Cuff Repair With and Without Concomitant Biceps Intervention: A Retrospective Review of Patient Outcomes
Authors: Nemirov Daniel A. , Herman Zachary , Paul Ryan W. , Beucherie Matthew , Hadley Christopher J. , Ciccotti Michael G. , Freedman Kevin B. , Erickson Brandon J. , Hammoud Sommer , Bishop Meghan E. 
Published: April 2022

Background: Biceps tendon pathology is common in patients with rotator cuff tears. Leaving biceps pathology untreated in rotator cuff repairs (RCRs) may lead to suboptimal outcomes. Purpose/Hypothesis: The purpose was to compare clinical outcomes between patients who underwent isolated RCR versus patients who underwent RCR with concomitant biceps treatment. It was hypothesized that there would be no difference in clinical outcomes between groups. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 244 patients who underwent RCR in 2016 were included. Patient characteristics, presence of concomitant biceps pathology, pre- and postoperative American Shoulder and Elbow Surgeons (ASES) scores, rotator cuff failure, revision surgery, and complications were recorded. Results: There were no significant differences between patients who underwent isolated RCR (n = 143) and those who underwent RCR with biceps treatment (n = 101) at 2 years postoperatively in ASES scores (RCR, 81.5; RCR+biceps treatment, 79.5; P = .532), cuff failure rate (5.6% vs 4.0%; P = .760), revision RCR rate (3.5% vs 2.0%; P = .703), or complication rate (11.9% vs 5.0%; P = .102). Furthermore, when comparing concomitant biceps tenotomy (n = 30) versus concomitant biceps tenodesis (n = 71), there were no differences in ASES scores ( P = .149), cuff failure rate ( P > .999), revision RCR rate ( P > .999), or complication rate ( P > .999) postoperatively. Finally, when comparing arthroscopic biceps tenodesis (n = 50) versus subpectoral biceps tenodesis (n = 21), there were no differences in ASES scores ( P > .592), cuff failure rate ( P > .999), revision RCR rate ( P = .507), or complication rate ( P > .999) 2 years postoperatively. Conclusion: Addressing biceps pathology when performing RCR resulted in similar rates of cuff failure, revision RCR, and complications, as well as a similar improvement in patient-reported outcomes when compared with isolated RCR at 2 years postoperatively. Furthermore, when comparing tenotomy versus tenodesis and arthroscopic versus subpectoral tenodesis, comparable outcomes with regard to rate of rotator cuff repair failure, revision RCR, complications, and patient-reported outcomes were found.
Phenotypic Spectrum in a Family Sharing a Heterozygous KCNQ3 Variant
Authors: Arredondo Kristen , Myers Cortlandt , Hansen-Kiss Emily , Mathew Mariam T. , Jayaraman Vijayakumar , Siemon Amy , Bartholomew Dennis , Herman Gail E. , Mori Mari 
Published: April 2022

Background and Purpose Mutations in KCNQ3 have classically been associated with benign familial neonatal and infantile seizures and more recently identified in patients with neurodevelopmental disorders and abnormal electroencephalogram (EEG) findings. We present 4 affected patients from a family with a pathogenic mutation in KCNQ3 with a unique constellation of clinical findings. Methods A family of 3 affected siblings and mother sharing a KCNQ3 pathogenic variant are described, including clinical history, genetic results, and EEG and magnetic resonance imaging (MRI) findings. Results This family shows a variety of clinical manifestations, including neonatal seizures, developmental delays, autism spectrum disorder, and anxiety. One child developed absence epilepsy, 2 children have infrequent convulsive seizures that have persisted into childhood, and their parent developed adult-onset epilepsy. An underlying c.1091G>A (R364H) variant in KCNQ3 was found in all affected individuals. Conclusions The phenotypic variability of KCNQ3 channelopathies continues to expand as more individuals and families are described, and the variant identified in this family adds to the understanding of the manifestations of KCNQ3-related disorders.
Survival After Severe COVID-19: Long-Term Outcomes of Patients Admitted to an Intensive Care Unit
Authors: Neville Thanh H. , Hays Ron D. , Tseng Chi-Hong , Gonzalez Cynthia A. , Chen Lucia , Hong Ashley , Yamamoto Myrtle , Santoso Laura , Kung Alina , Schwab Kristin , Chang Steven Y , Qadir Nida , Wang Tisha , Wenger Neil S. 
Published: April 2022

Background Understanding the long-term sequelae of severe COVID-19 remains limited, particularly in the United States. Objective To examine long-term outcomes of patients who required intensive care unit (ICU) admission for severe COVID-19. Design, Patients, and Main Measures This is a prospective cohort study of patients who had severe COVID-19 requiring an ICU admission in a two-hospital academic health system in Southern California. Patients discharged alive between 3/21/2020 and 12/31/2020 were surveyed approximately 6 months after discharge to assess health-related quality of life using Patient-Reported Outcomes Measurement Information System (PROMIS®)-29 v2.1, post-traumatic stress disorder (PTSD) and loneliness scales. A preference-based health utility score (PROPr) was estimated using 7 PROMIS domain scores. Patients were also asked their attitude about receiving aggressive ICU care. Key Results Of 275 patients admitted to the ICU for severe COVID-19, 205 (74.5%) were discharged alive and 132 (64%, median age 59, 46% female) completed surveys a median of 182 days post-discharge. Anxiety, depression, fatigue, sleep disturbance, ability to participate in social activities, pain interference, and cognitive function were not significantly different from the U.S. general population, but physical function (44.2, SD 11.0) was worse. PROPr mean score of 0.46 (SD 0.30, range −0.02 to 0.96 [<0 is worse than dead and 1 represents perfect health]) was slightly lower than the U.S. general population, with an even distribution across the continuum. Poor PROPr was associated with chronic medical conditions and receipt of life-sustaining treatments, but not demographics or social vulnerability. PTSD was suspected in 20% and loneliness in 29% of patients. Ninety-eight percent of patients were glad they received life-saving treatment. Conclusion Most patients who survive severe COVID-19 achieve positive outcomes, with health scores similar to the general population at 6 months post-discharge. However, there is marked heterogeneity in outcomes with a substantial minority reporting severely compromised health.
Communication About Food and Nutrition in the Parent Child Dyad
Authors: Jackson Alexandra , Sano Yoshie , Cox Anne E. , Lee SuYeon , Lanigan Jane 
Published: April 2022

Purpose Developmentally appropriate messaging interventions may be an effective way to promote healthy behaviors in young children. However, there is a gap in the literature describing communication about food and nutrition within the parent-child dyad. Thus, we explored the content, frequency, context, and purpose of parental conversations about food and nutrition. Design Using a semi-structured interview guide, 20 in-person interviews were conducted with parents of 3 to 9 year old children living in Washington and Oregon at the location of their choice. Methods Qualitative data was analyzed using open coding and grounded theory. Results Three categories described communication within the dyad: purpose, content, and the bidirectional interaction between the parent and the child. Purpose included three themes: consumption, variety, and balance. Content included three themes: food-related content, body-related content, and utilizing connections. Subthemes within food-related content included properties, production, and preparation. Body-related content subthemes were utilization of food in the body and interoceptive awareness. Parents highlighted connections between the food and body-related content. Lastly, parent–child conversations about food and nutrition were dynamic and bidirectional with parents adapting to child factors. Conclusion Our findings provide a description of parent communication about food and nutrition and suggest investigation of the purpose and content of communication and how parents tailor messages to their child.
Feeding Patterns of Healthy Term Newborns in the First 5 Days—The Glucose in Well Babies Study (GLOW)
Authors: Harris Deborah L , Weston Philip J , Harding Jane E 
Published: April 2022

Background: The feeding patterns of healthy newborns have been poorly described. Research Aim: To determine the feeding patterns of healthy term newborns soon after birth, and if these differed with sex, gestation, and mode of birth. Methods: This study was a prospective, longitudinal observational cohort study. Term, appropriately grown newborns ( N = 66) were fed according to maternal choice and details were recorded. Data were analyzed using generalized Poisson regression for feeding frequencies, and mixed model regression of log-transformed data for durations. Results: The participants completing the study had a M = 3589 g ( SD = 348 g) birthweight, with a gestation age of M = 40.1 (1.2) weeks. All participants were breastfed; 23 (35%) also received expressed human milk and 10 (15%) received formula. Participants had fewer feeding sessions on Day 1, ( M = 7.3 [1.9] sessions/day) increasing to ( M = 9.4 [2.4] sessions/day) by Day 3, then reducing to ( M = 9.0 [2.2] sessions/day) on Day 5, p < .001. The overall duration of breastfeeding sessions varied widely ( Mdn = 29 [range = 1–447] min). Feed frequency but not duration was higher in males than females ( M = 8.9, SE = 0.2 vs. 8.1, 02, sessions/day, p = .03), in newborns born ≥ 40 weeks’ gestation ( M = 8.9, SE = 0.3 vs. 8.2, 02, sessions/day, p = .04), and in newborns born by Caesarean section ( M = 9.4, SE = 0.3 vs. 8.4, 02, sessions/day, for vaginal birth, p = .003). Conclusion: Feeding patterns of healthy term newborns vary widely, but frequency increases during the first 3 days, and is greater in males, newborns born late term, and born by Caesarean section. Clinical Trial Registration: The Australian and New Zealand Clinical Trials Registry Ref: ACTRN12615000986572. The study protocol is available online: http://hdl.handle.net/2292/32066
The Twilight Zone: Oxybutynin Overuse Exacerbating Delirium
Authors: Marthi Siddharth , Pomerantz Madison A. , Mernan Andrea J. , Berlow Yosef A. 
Published: April 2022

Anticholinergic medications, such as oxybutynin, are first-line pharmacologic therapies in overactive bladder. However, the cognitive adverse effect profiles of frequently used anticholinergic medications are extensive and limit their use in older patients. Additionally, many older patients continue on anticholinergic therapy if adverse effects are not self-reported by the patient or detected by the provider. Here, we present a case of a 73-year-old male with a history of major neurocognitive disorder, in which unreported oxybutynin overuse led to repeated delirious states, erratic driving, and subsequent psychiatric hospitalizations. During his hospitalizations, he displayed progressively more linear thought processes and improved insight without clear etiology. After a more thorough history of his medication use was obtained, he disclosed that he would often take additional doses of oxybutynin to prevent incontinence during car rides and had done so prior to recent hospitalizations. Our example highlights the importance of thorough history taking, medication review, reducing polypharmacy, careful patient education about medications with psychiatric adverse effects, and, importantly, the avoidance of anticholinergic medication prescription in older patients.
Real-world performance of Victorian hospitals during the COVID-19 lockdowns
Authors: Allison Stephen , Bastiampillai Tarun , Looi Jeffrey CL , Copolov David , Lakra Vinay 
Published: April 2022

Objective Victoria has low numbers of general adult psychiatric beds per capita by Australian and international standards. Hospital key performance indicators (KPIs) such as bed occupancy rates, emergency department waiting times and inpatient lengths of stay are proximal measures of the effects any shortfall in beds. We investigate the real-world performance of Victorian hospitals during the first year of the COVID-19 pandemic and the extended lockdowns in 2020. Conclusions The Victorian inpatient psychiatric system is characterised by high bed occupancies in many regions, extended stays in emergency departments awaiting a bed, and short inpatient lengths of stay, except for patients with excessively long stays on acute units (over 35 days) who are unable to be admitted to non-acute facilities. At the end of 2020, bed occupancies were high (above 90%) in 10 regions, with three regions having bed occupancies over 100%. However, state-wide average bed occupancy improved between 2019 (94%) and 2020 (88%). Other KPIs remained steady because acute hospitals did not experience the expected pandemic mental health demand-surge. For a more complete picture of the impact of the pandemic, Australia needs interconnected, centralised data systems.
Quality of MIS vs Open Joint Preparations of the Foot and Ankle
Authors: Zhao John Z. , Kaiser Philip B. , DeGruccio Christina , Farina Evan M. , Miller Christopher P. 
Published: April 2022

Background: Minimally invasive surgery (MIS) is growing in the field of foot and ankle, and the MIS burr is an emerging tool. Although commonly used to perform osteotomies, the burr can also be used for arthrodesis joint preparation that traditionally would be performed through open incisions. To date, there is no study comparing the quality of joint preparation between using a fluoroscopy-guided MIS technique compared to traditional open techniques. The goal of this cadaveric study is to compare the percentage of joint surfaces prepared between MIS and open techniques for the most common joints that are fused in foot and ankle surgery. Methods: Open joint preparation was performed under direct visualization with open incisions. MIS joint preparation was performed percutaneously using fluoroscopic guidance alone, without arthroscopy. After joint preparation, cadaveric samples were disarticulated, and joint surfaces were analyzed for percentage of cartilaginous surface removed. The percentage of joint surface prepared was compared between the open and MIS techniques. Results: Ten cadaveric samples were used for the MIS technique and 5 samples for the open technique. Percentage of joint surface prepared was similar for all joint surfaces. Conclusion: The MIS technique in the hands of experienced surgeons was found to provide overall similar percentages of surface area prepared compared to traditional open techniques. Clinical Relevance: MIS joint preparation may be useful for specific patient populations. This study suggests that MIS joint preparation is a reasonable, and possibly advantageous, alternative to open preparation in arthrodesis surgery when performed by experienced MIS surgeons.
Two-Step 3D-Guided Supramalleolar Osteotomy to Treat Varus Ankle osteoarthritis
Authors: van Raaij Tom , van der Wel Hylke , Beldman Mark , de Vries Astrid , Kraeima Joep 
Published: April 2022

Background: Success of valgus-type supramalleolar osteotomy (SMOT) depends on adequate correction of malalignment, which can be hard to achieve with current 2-dimensional (2D) planning and operative techniques. A personalized digital 3-dimensional (3D) workflow to virtually plan and perform a 2-step 3D-guided medial opening (MO) SMOT has the potential to improve precision of correction. Methods: Computed tomography (CT)–based Proplan medical 3D models were made to virtually plan the desired MO SMOT, and exported to 3-Matic medical to develop patient-specific 2-step cutting and wedge guides. Workflow accuracy was tested in this limited clinical pilot study (3 patients) by comparing the virtual planned position of the osteotomized distal tibial fragment with the 1-year post-MO SMOT configuration. Two millimeters or less translation deviation in every plane was defined as accurate. Results: Primary outcome analysis of the osteotomized distal tibial fragment deviation showed a median translation in all planes of 0.7 (range 0-8.2) mm (interquartile range 1.55) with an excellent interrater reliability of the measurements (intraclass correlation coefficient 0.998). There was a strong reduction in ankle pain as reflected by an increase of the AOFAS-AH score and decrease of NRS pain score with an unrestricted hindfoot motion 1 year after surgery. Conclusion: 3D virtually planned bone cutting and wedge guides is a promising approach associated with minimal postoperative deviation from the desired correction in medial opening supramalleolar osteotomy.
Factors Associated With Bullying Victimization and Bullying Perpetration in Children and Adolescents With ADHD: 2016 to 2017 National Survey of Children’s Health
Authors: Cuba Bustinza Carolina , Adams Ryan E. , Claussen Angelika H. , Vitucci Daniel , Danielson Melissa L. , Holbrook Joseph R. , Charania Sana N. , Yamamoto Kaila , Nidey Nichole , Froehlich Tanya E. 
Published: April 2022

Objective: To identify characteristics associated with bullying involvement in pediatric ADHD. Methods: Data from the 2016 to 2017 National Survey of Children’s Health for children aged 6 to 17 years with ADHD were evaluated to assess the association between parent-reported bullying victimization or perpetration and the following potential predictors: demographic characteristics, family factors, school factors, and child conditions/behaviors. Results: Among children with ADHD, 46.9% were bullying victims and 16.2% were perpetrators. Factors associated with victimization included having family financial strain, developmental delay or intellectual disability, friendship difficulties, and school reports about problems. Factors linked to perpetration included being male, receiving government assistance, lack of school engagement, school reports about problems, and having difficulties with friendships, staying calm, and arguing. Conclusions: Children with ADHD frequently were bullying victims and sometimes bullying perpetrators. Factors related to family financial strain, developmental disabilities, emotional regulation, peer relationships, and school functioning may help to identify risk for bullying and opportunities for anti-bullying interventions.
Late internalized double-flanged polypropylene with canabrava technique in patient with marfan syndrome
Authors: Canabrava Sérgio , Pinheiro Laura , Chaves Vizibelli , Barrientos Robinson 
Published: April 2022

IntroductionThis paper reports the first occurrence of a late internalized flange due to capsular contraction syndrome after undergoing the double-flanged surgical technique.Case DescriptionA 32-year-old woman with Marfan syndrome underwent phacoemulsification using the double-flanged technique in both eyes. Two years postoperatively, a slit lamp examination revealed a capsular bag with anterior phimosis (capsular contraction syndrome) and the external flange internalized. The patient was submitted for a new surgery to re-fixate the capsular bag. The procedure was successfully accomplished. The intraocular lens was centered by the end of the procedure without areas of traction. The patient presented with best corrected visual acuity of 20/25 in both eyes postoperatively.ConclusionsThis paper recounts a successful re-approach of a late internalized double-flange two years after the first procedure in a patient that developed capsular contraction syndrome.
Defining bilingualism in infancy and toddlerhood: A scoping review
Authors: Rocha-Hidalgo Joscelin , Barr Rachel 
Published: April 2022

Aims and objectives: The aim of this manuscript is to provide an overview of the population and languages studied and the methods and practices surrounding the definition of bilingualism in children below age 3. Methodology: A quantitative descriptive scoping review Data and analysis: From 530 articles, we identified 127 papers (167 studies) that met our predefined criteria, of which 144 studies defined their bilingual population. Findings/conclusions: The samples investigated were predominantly western in geographical origin and languages. Percent exposure was the most common method to measure bilingualism among infants and young children, with 20% and 25% the most used cutoffs as the minimum requirement for children’s second language. We also analyzed the predictive value of these cutoffs on the likelihood that studies reported a significant difference between monolinguals and bilinguals. The stricter the inclusion requirement for bilinguals was, the higher the odds of a study to report a difference between monolingual and bilingual children. We conclude that a lack of uniformity of definition in the field may be one factor that predicts whether or not significant differences are reported. Originality: This scoping review provides developmental researchers with a unique overview of the different practices used in the field to characterize bilingual and monolingual infants/toddlers. The reported results can be used as preliminary evidence for the field to report and carefully formulate how to categorize monolinguals and bilingual infants. Significance/implications: As globalization continues to foster migration and intercultural exchange, it is essential for developmental researchers to diversify their samples and language groups. We highly encourage researchers to carefully document the definitions and rationale for all their language groups and to consider analyzing the impact of bilingualism both from a categorical and continuous approach.
Addressing Risk Perceptions of Low-Dose Radiation Exposure
Authors: Hurlbert Margot , Shasko Larissa , Neetz MIchaela 
Published: April 2022

Concern over low-dose radiation (LDR) (exposure of less than 100 milligray (mGy)) is resulting in people refusing diagnostic procedures and medical treatment 1 and also inhibiting revision of the linear no-threshold (LNT) assumption that informs much of science policy. This article reviews representative surveys in Ontario and Saskatchewan and focus groups conducted with science and policy stakeholders in addressing how the public and policy stakeholders understand issues of exposure to LDR and how policy issues can be addressed. Research results from focus groups demonstrated that policy stakeholders are knowledgeable about issues surrounding the public and perceptions about LDR and implications for policy consistent with LDR literature. Participants understood that the challenge went beyond providing more education about LDR and issues of emotions and biases must be addressed. This research resulted in rich suggestions for public communication and engagement surrounding LDR and a process for addressing the issue of the LNT.