bluuebunny/crossref_metadata_2025_split huggingface dataset:
Light and Period Variations in Two K-type Contact Binaries: HI Leo and V523 Cas
Authors: Yang Yuangui , Wang Shuang , Yuan Huiyu , Dai Haifeng 
Published: October 2022

Abstract
We presented a low-precision spectrum for HI Leo, Transiting Exoplanet Survey Satellite data for V523 Cas, and new photometry for both K-type contact binaries. Comparing their light curves on different observing dates, we found small intrinsic variabilities, such as variable amplitudes for HI Leo and the varying heights around the second maxima for V523 Cas. By the Wilson–Devinney Code, we deduced six photometric solutions. The dark spot of V523 Cas may appear on the surface of the more massive component on BJD 2458768, while it disappears on BJD 2458779. Our results indicate that the two binaries are W-type shallow-contact binaries (f ≤ 10%). From the eclipse timing residuals, we found that the orbital periods may continuously increase, accompanied by one to two light-time effects due to additional bodies. The modulated periods and semi-amplitudes are P
3 = 25.8(±1.0) yr and A
3 = 0.ͩ0066(6) for HI Leo, P
3 = 114.8(±2.0) yr and A
3 = 0.ͩ0448(12), P
4 = 18.89(±0.14) yr and A
4 = 0.ͩ0025(2) for V523 Cas, respectively. The orbital period secularly increases at a rate of dP/dt = 2.86(±0.11) × 10−7 day yr−1 for HI Leo and dP/dt = 3.45(±0.07) × 10−8 day yr−1 for V523 Cas, which may be attributed to mass transfer from the secondary to the primary. With mass transferring, the shallow-contact binaries, HI Leo and V523 Cas, will evolve into the broken-contact configurations.
The Role of Jets in Exploding Supernovae and in Shaping their Remnants
Authors: Soker Noam 
Published: October 2022

Abstract
I review studies of core collapse supernovae (CCSNe) and similar transient events that attribute major roles to jets in powering most CCSNe and in shaping their ejecta. I start with reviewing the jittering jets explosion mechanism that I take to power most CCSN explosions. Neutrino heating does play a role in boosting the jets. I compare the morphologies of some CCSN remnants to planetary nebulae to conclude that jets and instabilities are behind the shaping of their ejecta. I then discuss CCSNe that are descendants of rapidly rotating collapsing cores that result in fixed-axis jets (with small jittering) that shape bipolar ejecta. A large fraction of the bipolar CCSNe are superluminous supernovae (SLSNe). I conclude that modeling of SLSN light curves and bumps in the light curves must include jets, even when considering energetic magnetars and/or ejecta interaction with the circumstellar matter (CSM). I connect the properties of bipolar CCSNe to common envelope jets supernovae (CEJSNe) where an old neutron star or a black hole spirals-in inside the envelope and then inside the core of a red supergiant. I discuss how jets can shape the pre-explosion CSM, as in Supernova 1987A, and can power pre-explosion outbursts (precursors) in binary system progenitors of CCSNe and CEJSNe. Binary interaction also facilitates the launching of post-explosion jets.
Generating and measuring pico-radian angles
Authors: Alcock Simon G , Yacoot Andrew , Ince Rabia , Patel Hiten 
Published: October 2022

Abstract
The angular performance of a nano-angle generator (NANGO) developed at Diamond Light Source has been characterised using a dual-beam laser interferometer designed and built at the National Physical Laboratory (NPL). NANGO is a flexure-based, piezo actuated device which generates milli- to sub-nano-radian angles for the calibration of metrology instruments used to test the quality of synchrotron x-ray mirrors and angular nano-positioning stages at Diamond. The NPL interferometer provides traceability for small angle measurements made by NANGO. An uncertainty budget has been developed for measurements over a 50 nanoradian range. In closed-loop, using feedback from the NANGO’s angle encoder, for the first time we show that 1 nanoradian steps made by NANGO are measurable by an external metrology device. The 200 kHz acquisition rate of the NPL angle interferometer also reveals new dynamic information about NANGO’s angular motion. The NPL interferometer demonstrates that NANGO in open-loop can make: distinct steps of 500 picoradians; sinusoidal oscillations at 0.4 Hz with an amplitude of 125 picoradians; or 1 nanoradian oscillations at 40 Hz. Traceability to the SI though National Metrology Institute instrumentation for NANGO will provide enhanced accuracy for a wide range of angle metrology applications at Diamond, including inputs to deterministic polishing techniques for the creation of next-generation x-ray mirrors and dynamic characterisation of nano-positioning stages.
Partition pooling for convolutional graph network applications in particle physics
Authors: Bachlechner M. , Birkenfeld T. , Soldin P. , Stahl A. , Wiebusch C. 
Published: October 2022

Abstract
Convolutional graph networks are used in particle physics
for effective event reconstructions and classifications. However,
their performances can be limited by the considerable amount of
sensors used in modern particle detectors if applied to sensor-level
data. We present a pooling scheme that uses partitioning to create
pooling kernels on graphs, similar to pooling on images. Partition
pooling can be used to adopt successful image recognition
architectures for graph neural network applications in particle
physics. The reduced computational resources allow for deeper
networks and more extensive hyperparameter optimizations. To show
its applicability, we construct a convolutional graph network with
partition pooling that reconstructs simulated interaction vertices
for an idealized neutrino detector. The pooling network yields
improved performance and is less susceptible to overfitting than a
similar network without pooling. The lower resource requirements
allow the construction of a deeper network with further improved
performance.
Effect of platelet-rich plasma scaffolding combined with osteochondral autograft transfer for full-thickness articular cartilage defects of the femoral condyle
Authors: Li Ming , Tu Yiji , Zhang Haojun , Zhang Yunfeng , Di Zhenglin 
Published: October 2022

Abstract
We aimed to investigate the local application methods of platelet-rich plasma (PRP) and the effect and safety of PRP scaffolding combined with osteochondral autograft transfer (OAT) in the treatment of full-thickness articular cartilage defects of the femoral condyle. Patients with cartilage defects of the femoral condyle were treated with OAT combined with PRP scaffolding between July 2017 and December 2020. Preoperative magnetic resonance imaging (MRI) and computed tomography were utilized to assess the size, location, and severity of the osteochondral defects. X-ray and MRI images of the knee were obtained at the final follow-up to assess the osseointegration and integrity of the implanted articular cartilage. Osteoarthritic changes in the knee joint were evaluated using the Kellgren–Lawrence grading system. Clinical status was assessed using the visual analog scale (VAS), International Knee Documentation Committee (IKDC), and Lysholm scores before the treatment and at the final follow-up. Complications and patient satisfaction were recorded to assess the safety of this combination therapy. Twenty-one patients were recruited, with a mean follow-up duration of 18.23 ± 6.84 months. The mean lesion size was 2.3 ± 0.59 cm2. The mean platelet concentration in PRP at baseline was 6.27 ± 0.63 times greater than that in the peripheral blood. The VAS, IKDC, and Lysholm scores had improved significantly at the final follow-up (P < 0.001). No serious complications such as joint infection, deep venous thrombosis, or hematoma were observed. Eighteen patients (85.72%) were satisfied with their knee function and quality of life at the final follow-up. Three patients (14.28%) complained of mild anterior knee pain, which was relieved by oral administration of nonsteroidal anti-inflammatory drugs. MRI examinations of all patients showed bony consolidation and the defect surface was covered with cartilage-like tissue. X-ray evaluations indicated that osteoarthritis in two knees (9.5%) had progressed from grade 1 to grade 2 at the final follow-up. The preliminary results showed that OAT combined with PRP may be a safe and effective technique for the treatment of full-thickness articular cartilage defects in the knee.
Heart-on-a-chip using human iPSC-derived cardiomyocytes with an integrated vascular endothelial layer based on a culture patch as a potential platform for drug evaluation
Authors: Tang Yadong , Tian Feng , Miao Xiaomin , Wu Dianqi , Wang Yaqi , Wang Han , You Kai , Li Qinglan , Zhao Suqing , Wang Wenlong 
Published: October 2022

Abstract
Many strategies have been adopted to construct in vitro myocardium models, which are of great value to both drug cardiotoxicity evaluation and cardiovascular drug development. In particular, the recent rapid development of human-induced pluripotent stem cell (hiPSC) technology and the rise of the organ-on-a-chip technique have provided great potential to achieve more physiologically relevant in vitro models. However, recapitulating the key role of the vasculature endothelial layer in drug action on myocardium in the models is still challenging. In this work, we developed an openable heart-on-a-chip system using highly purified functional hiPSC-derived cardiomyocytes (hiPSC-CMs) with an integrated vascular endothelial layer based on our previously proposed culture-patch method. The purity and functionality of the differentiated hiPSC-CMs were characterized, which were applied into the lower chamber of the sandwich-structured device to form the CM layer. The integrity and cell morphology of the endothelial layer on the culture patch as well as the influence of fluid shear force were studied, which was integrated in between the upper and lower chambers. The constructed heart-on-a-chip was finally applied for drug testing. The effect of two cardiac targeting drugs (isoproterenol and E-4031) directly on the hiPSC-CMs or after penetrating through the endothelial layer under static or dynamic conditions was evaluated. The results demonstrated the significance of a vascular layer in in vitro myocardium models for drug testing, as well as the advantage and potential of the proposed platform for cardiovascular drug evaluation with more human physiological relevance.
Band alignment and interlayer hybridisation in transition metal dichalcogenide/hexagonal boron nitride heterostructures
Authors: Magorrian S J , Graham A J , Yeung N , Ferreira F , Nguyen P V , Barinov A , Fal’ko V I , Wilson N R , Hine N D M 
Published: October 2022

Abstract
In van der Waals heterostructures, the relative alignment of bands between layers, and the resulting band hybridisation, are key factors in determining a range of electronic properties. This work examines these effects for heterostructures of transition metal dichalcogenides (TMDs) and hexagonal boron nitride (hBN), an ubiquitous combination given the role of hBN as an encapsulating material. By comparing results of density functional calculations with experimental angle-resolved photoemission spectroscopy (ARPES) results, we explore the hybridisation between the valence states of the TMD and hBN layers, and show that it introduces avoided crossings between the TMD and hBN bands, with umklapp processes opening ‘ghost’ avoided crossings in individual bands. Comparison between density functional theory (DFT) and ARPES spectra for the MoSe2/hBN heterostructure shows that the valence bands of MoSe2 and hBN are significantly further separated in energy in experiment as compared to DFT. We then show that a novel scissor operator can be applied to the hBN valence states in the DFT calculations, to correct the band alignment and enable quantitative comparison to ARPES, explaining avoided crossings and other features of band visibility in the ARPES spectra.
A clean and efficient method for purifying crude selenium based on a selective leaching - directed decomposition purification process
Authors: Xu Na , He Xiaocai , Xu Qingxin , Diao Weizhi , Yan Sen , He Qiugu , Ren Tin 
Published: October 2022

Abstract
The rare element selenium is a key material in supporting the development of high-tech and new products. This research has led to the development of a method of purifying crude selenium based on a selective leaching-directed decomposition purification process. The influence of factors such as the concentration of the leaching solution, leaching temperature, solid-liquid ratio, and leaching time on the leaching rate of Se were investigated in detail. The experimental results show that the optimal conditions for selective leaching of selenium were as follows: the concentration of leaching solution (solute: Na2SO3) was 260 g l−1, the stirring speed was 300 rpm, the ratio of liquid to solid was 0.10 g ml−1, the reaction temperature was 90 °C, the reaction time was 180 min, and the leaching rate of selenium on one run was >95%. The products of selenium after two runs meet the requirements of Se99.9 in YS/223–2007, the Chinese nonferrous metal industry standard. The direct yield of Se is greater than 90%, and precious metals such as gold, silver and platinum are enriched in the residue. No waste is produced during the whole purification process, and all products can be recycled. This study provides an efficient and environmentally friendly method for the purification of crude selenium, which has important industrial applications.
An efficient deep neural network accelerator using controlled ferroelectric domain dynamics
Authors: Majumdar Sayani 
Published: October 2022

Abstract
The current work reports an efficient deep neural network (DNN) accelerator, where analog synaptic weight elements are controlled by ferroelectric (FE) domain dynamics. An integrated device-to-algorithm framework for benchmarking novel synaptic devices is used. In poly(vinylidene fluoride-trifluoroethylene)-based ferroelectric tunnel junctions (FTJs), analog conductance states are measured using a custom pulsing protocol, and associated control circuits and array architectures for DNN training are simulated. Our results show that precise control of polarization switching dynamics in multi-domain polycrystalline FE thin films can produce considerable weight-update linearity in metal–ferroelectric–semiconductor (MFS) tunnel junctions. Ultrafast switching and low junction currents in these devices offer extremely energy-efficient operation. Via an integrated platform of hardware development, characterization and modeling, we predict the available conductance range, where linearity is expected under identical potentiating and depressing pulses for efficient DNN training and inference tasks. As an example, an analog crossbar-based DNN accelerator with MFS junctions as synaptic weight elements showed >93% training accuracy on a large MNIST handwritten digit dataset while, for cropped images, >95% accuracy is achieved. One observed challenge is the rather limited dynamic conductance range while operating under identical potentiating and depressing pulses below 1 V. Investigation is underway to improve the FTJ dynamic conductance range, maintaining the weight-update linearity under an identical pulse scheme.
Harnessing Google Health Trends Data for Epidemiologic Research
Authors: Neumann Krista , Mason Susan M , Farkas Kriszta , Santaularia N Jeanie , Ahern Jennifer , Riddell Corinne A 
Published: October 2022

AbstractInterest in using internet search data, such as that from the Google Health Trends Application Programming Interface (GHT-API), to measure epidemiologically relevant exposures or health outcomes is growing due to their accessibility and timeliness. Researchers enter search term(s), geography, and time period, and the GHT-API returns a scaled probability of that search term, given all searches within the specified geographic-time period. In this study, we detailed a method for using these data to measure a construct of interest in 5 iterative steps: first, identify phrases the target population may use to search for the construct of interest; second, refine candidate search phrases with incognito Google searches to improve sensitivity and specificity; third, craft the GHT-API search term(s) by combining the refined phrases; fourth, test search volume and choose geographic and temporal scales; and fifth, retrieve and average multiple samples to stabilize estimates and address missingness. An optional sixth step involves accounting for changes in total search volume by normalizing. We present a case study examining weekly state-level child abuse searches in the United States during the coronavirus disease 2019 pandemic (January 2018 to August 2020) as an application of this method and describe limitations.
The Norton Healthcare electronic antimicrobial stewardship program: An opt-out approach to antimicrobial stewardship
Authors: Wilde Ashley M , Song Matthew , Moore Sarah E , Bohn Brian C , Swingler Elena A , Schulz Paul S 
Published: October 2022

Abstract

Purpose
To describe the Norton Healthcare electronic antimicrobial stewardship program (E-ASP), a novel prospective audit and feedback approach that leverages the electronic medical record to overcome efficiency barriers. Additionally, to describe an accompanying opt-out antimicrobial stewardship approach that addresses provider nonresponsiveness.

Summary
Prospective audit and feedback is recommended by antimicrobial stewardship guidelines; however, execution can be difficult due to labor requirements, delays in communication, and provider nonparticipation. The Norton E-ASP was developed to address these issues by reliably identifying target patients, documenting assessments, streamlining recommendation delivery, promoting handoff, and providing automated tracking of recommendation responses. Opt-out stewardship allows recommendations to be implemented if not rejected after 24 hours.

Conclusion
A 25% reduction in target antimicrobial use has been achieved and sustained with the program. Use of the Norton E-ASP, including opt-out antimicrobial stewardship, broadened the reach and furthered the impact of infectious diseases pharmacists. Successes of this program justified addition of 3 full-time infectious diseases pharmacist positions at a large community health system. This strategy may serve as a model for tele-antimicrobial stewardship or other pharmacy recommendations.
wenda_gpu: fast domain adaptation for genomic data
Authors: Hippen Ariel A , Crawford Jake , Gardner Jacob R , Greene Casey S 
Published: October 2022

AbstractMotivationDomain adaptation allows for the development of predictive models even in cases with limited sample data. Weighted elastic net domain adaptation specifically leverages features of genomic data to maximize transferability but the method is too computationally demanding to apply to many genome-sized datasets.ResultsWe developed wenda_gpu, which uses GPyTorch to train models on genomic data within hours on a single GPU-enabled machine. We show that wenda_gpu returns comparable results to the original wenda implementation, and that it can be used for improved prediction of cancer mutation status on small sample sizes than regular elastic net.Availability and implementationwenda_gpu is available on GitHub at https://github.com/greenelab/wenda_gpu/.Supplementary informationSupplementary data are available at Bioinformatics online.
A yes-associated protein 1- Notch1 receptor positive feedback loop promotes breast cancer lung metastasis by attenuating the bone morphogenetic protein 4-SMAD family member 1/5 signaling
Authors: Zhao Lin , Lei Jianjun , Gu Shanzhi , Zhang Yujiao , Jing Xin , Wang Lu , Zhang Lifen , Ning Qian , Luo Minna , Qi Yifan , Zhao Xinhan , Shao Shan 
Published: October 2022

Abstract
The Notch1 (Notch1 receptor) and yes-associated protein 1 (YAP1) signaling can regulate breast cancer metastasis. This study aimed at investigating whether and how these two signal pathways crosstalk to promote breast cancer lung metastasis. Here, we show that YAP1 expression was positively correlated with Notch1 in breast cancer according to bioinformatics and experimental validation. Mechanistically, YAP1 with TEA domain transcription factors (TEADs) enhanced Jagged1(JAG1)-Notch1 signaling. Meanwhile, Notch1 promoted YAP1 stability in breast cancer cells by inhibiting the β-TrCP-mediated degradation, thereby, forming a YAP1- JAG1/Notch1 positive feedback loop in breast cancer. Furthermore, YAP1 enhanced the mammosphere formation and stemness of MDA-MB-231 cells by attenuating the inhibition of the BMP4-SMAD1/5 signaling. In vivo, the YAP1- JAG1/Notch1 positive feedback loop promoted the lung colonization of MDA-MB-231 cells. Our data for the first time indicate that the YAP1-Notch1 positive feedback loop promotes lung metastasis of breast cancer by modulating self-renewal and inhibiting the BMP4-SMAD1/5 signaling.
‘Participation—with what money and whose time?’ An intersectional feminist analysis of community participation
Authors: Fursova Julia , Bishop-Earle Denise , Hamilton Kisa , Kranias Gillian 
Published: October 2022

Abstract
The paper presents the results of community-based participatory action research that evaluated the quality and extent of resident participation in community development projects initiated by a network of non-profit and public agencies in a lower-income, racialized neighbourhood in Toronto. The paper examines dynamics of community engagement and volunteer participation in relation to the socio-political context of neoliberal urban development within which they unfold. Against this backdrop, the paper discusses processes of normalization and the mainstreaming of a technocratic or instrumental approach to community engagement. The paper argues how this instrumental approach extracts volunteer participation from residents to meet short-term organizational targets while offering no genuine opportunity for residents to co-create long-term, meaningful solutions to community needs and priorities. Such short-term, ‘band-aid’ community engagement and capacity building projects contribute to a crisis of trust between residents and the non-profit agencies. The paper presents a community engagement continuum mapping indicators for technocratic and extractivist community engagement in contrast to indicators for transformative and empowering processes.
A genetic screen for aldicarb resistance of C
aenorhabditis
elegans dauer larvae uncovers 2 alleles of dach-1, a cytochrome P450 gene
Authors: Son Sangwon , Choi Myung-Kyu , Lim Daisy S , Shim Jaegal , Lee Junho 
Published: October 2022

Abstract
Animals exhibit phenotypic plasticity through the interaction of genes with the environment, and little is known about the genetic factors that change synaptic function at different developmental stages. Here, we investigated the genetic determinants of how animal’s sensitivity to drugs that alter synaptic activity is regulated at a specific developmental stage using the free-living nematode Caenorhabditis elegans. C. elegans enters the stress-resistant dauer larval stage under harsh conditions. Although dauer is known to have reduced permeability and increased resistance to most known exogenous chemicals, we discovered that dauer is hypersensitive to a cholinesterase inhibitor, aldicarb. To investigate genes regulating dauer-specific acetylcholine transduction, we first screened for aldicarb-resistant mutations in dauer and then performed a secondary screen to rule out aldicarb-resistant mutations that also affect adults. We isolated 2 different mutations of a single gene called cyp-34A4 or dach-1 encoding a cytochrome P450. In the nondauer stages, dach-1 is mainly expressed in the intestine, but its expression is robustly increased in the epidermis of dauers. By tissue-specific rescue experiments, we found that dach-1 modulates aldicarb sensitivity in a cell nonautonomous manner. In addition, dach-1 plays pleiotropic functions in dauers by regulating quiescence and surviving heat shock and hyperosmolar stress. Our study reveals novel functions of the cytochrome P450 in synaptic and physiological changes during the developmental plasticity.