bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating Asian American Adolescents’ Resiliency Factors and Young Adult Mental Health Outcomes at 14-year Follow-up: A Nationally Representative Prospective Cohort Study
Authors: Iyer Puja , Parmar Deepika , Ganson Kyle T. , Tabler Jennifer , Soleimanpour Samira , Nagata Jason M. 
Published: July 2022

AbstractThere is scant research on how Asian American adolescents’ resiliency relates to mental well-being in adulthood. The objective of this study was to determine the prospective associations between resiliency factors (individual, family, and school community) in adolescence and mental health outcomes in adulthood, among a national sample of Asian Americans. We analyzed data from 1020 Asian American adolescents who were followed for 14 years in the National Longitudinal Study of Adolescent to Adult Health. Of the resiliency factors, individual self-esteem (Adjusted Odds Ratio [AOR] 0.54, 95% Confidence Interval [CI] 0.37–0.79) and family connectedness (AOR 0.78, 95% CI 0.65–0.93) in adolescence were found to be protective against adult mental health outcomes in logistic regression models adjusting for sociodemographic factors and baseline mental health. Our study identified individual and family resiliency factors which can be leveraged to help Asian American adolescents and families in cultivating better mental health.
The solution of Pennes' bio-heat equation with a convection term and nonlinear specific heat capacity using Adomian decomposition
Authors: Ostadhossein Rouhollah , Hoseinzadeh Siamak 
Published: July 2022

AbstractPennes' bio-heat equation is the most widely used equation to analyze the heat transfer phenomenon associated with hyperthermia and cryoablation treatments of cancer. In this study, the semi-analytical and numerical solutions of Pennes' equation in a highly nonlinear form derived from renal cell carcinoma tissue's nonlinear specific heat capacity along with a freezing convection term were obtained and analyzed for the first time. Here, the governing equation was reduced to a lumped capacity form for simplification and exerted on a solid spherical renal tumor. In the following, two semi-analytical techniques, the adomian decomposition method (ADM) and the Akbari–Ganji's method (AGM) were evaluated in solving the governing ODE. The comparison revealed full conformity between ADM and AGM, in addition to an excellent agreement between the semi-analytical and the numerical results before the phase transition. The analysis highlighted a deviation between the semi-analytical and numerical results for the limited convergence of power-series-based semi-analytical methods throughout the phase change and beyond. For the investigated case with $$D_{t} = 0.025,\quad {\text{Biot}} = 0.075$$

D
t

=
0.025
,

Biot
=
0.075

, the convergence occurred while $$\tau \in [0,0.7]$$

τ
∈
[
0
,
0.7
]

for both methods. Consequently, both semi-analytical techniques ADM and AGM, are applicable to find the solution of Pennes' bio-heat equation before the phase change, and there is no superiority in favor of one in accuracy. In contrast, numerical methods are reliable during the phase transition and after that. The analysis of the numerical solution showed that with the growth of the tumor, achieving the necrosis of the malignant tissue takes longer, and large tumors' temperature may not decrease to necrosis temperature. The interpretation of the numerical results indicated that cryoablation could be considered an effective thermal treatment for renal tumors with a diameter lower than 2.0 cm.
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions
Authors: Sun Bing-xin , Peng Ai-shi , Liu Pei-jie , Wang Min-jia , Ding Hai-li , Hu Yu-shi , Kang Liang 
Published: July 2022

AbstractThe neurotrophin brain-derived neurotrophic factor (BDNF), which acts as a transducer, is responsible for improving cerebral stroke, neuropathic pain, and depression. Exercise can alter extracellular nucleotide levels and purinergic receptors in central nervous system (CNS) structures. This inevitably activates or inhibits the expression of BDNF via purinergic receptors, particularly the P2X receptor (P2XR), to alleviate pathological progression. In addition, the significant involvement of sensitive P2X4R in mediating increased BDNF and p38-MAPK for intracerebral hemorrhage and pain hypersensitivity has been reported. Moreover, archetypal P2X7R blockade induces mouse antidepressant-like behavior and analgesia by BDNF release. This review summarizes BDNF-mediated neural effects via purinergic receptors, speculates that P2X4R and P2X7R could be priming molecules in exercise-mediated changes in BDNF, and provides strategies for the protective mechanism of exercise in neurogenic disease.
The P2X1 receptor as a therapeutic target
Authors: Bennetts Felix M. , Mobbs Jesse I. , Ventura Sabatino , Thal David M. 
Published: July 2022

AbstractWithin the family of purinergic receptors, the P2X1 receptor is a ligand-gated ion channel that plays a role in urogenital, immune and cardiovascular function. Specifically, the P2X1 receptor has been implicated in controlling smooth muscle contractions of the vas deferens and therefore has emerged as an exciting drug target for male contraception. In addition, the P2X1 receptor contributes to smooth muscle contractions of the bladder and is a target to treat bladder dysfunction. Finally, platelets and neutrophils have populations of P2X1 receptors that could be targeted for thrombosis and inflammatory conditions. Drugs that specifically target the P2X1 receptor have been challenging to develop, and only recently have small molecule antagonists of the P2X1 receptor been available. However, these ligands need further biological validation for appropriate selectivity and drug-like properties before they will be suitable for use in preclinical models of disease. Although the atomic structure of the P2X1 receptor has yet to be determined, the recent discovery of several other P2X receptor structures and improvements in the field of structural biology suggests that this is now a distinct possibility. Such efforts may significantly improve drug discovery efforts at the P2X1 receptor.
Shape dependence of the release rate of chemicals from plastic microparticles
Authors: Frazzetto Riccardo , Frezzato Diego 
Published: July 2022

AbstractThe release of chemical additives from plastic microparticles in the aqueous phase represents a potential indirect threat for environment and biota. The estimate of the release timescale is demanded for drawing sensible conclusions on quantitative grounds. While the microparticles are generally taken to be spherical for ease of modelling, in reality the variety of shapes is large. Here, we face the problem of working out an empirical simple expression for estimating the release times for arbitrary shapes, assuming that the plastic material is in the rubbery state, that the dynamics inside the particle is a diffusion process, and that the release is irreversible. Our inspection is based on numerical simulations of the release process for randomly generated instances of regular and irregular geometries. The expression that we obtain allows one to estimate the release time in terms of the corresponding time (easy to compute) for the equal-volume spherical particle taken as reference, and of the ratio between the surface areas of particle and equivalent sphere.
Theory Paper: Suggesting Compassion-Based Approaches for Treating Complex Post-traumatic Stress Disorder
Authors: Rushforth Annabel , Kotera Yasuhiro , Kaluzeviciute Greta 
Published: July 2022

AbstractComplex post-traumatic stress disorder (CPTSD) may develop following interpersonal and cumulative traumatic events, usually during early development. In addition to the core PTSD symptom profile, CPTSD presents emotional dysregulation symptoms that can be resistant to conventional treatments. Compassion-focused therapy (CFT) may be an effective intervention for addressing the more resistant symptoms in the emotional stabilisation phase of treatment rather than the trauma-processing phase. This paper explores the diagnostic validity and prevalence of CPTSD, treatment recommendations and the role of CFT in mediating shame and stabilising emotional dysregulation. We also evaluate current evidence utilising compassion-based interventions for the components of the CPTSD symptom profile and the viability of CFT as a whole. The novelty of CPTSD as a clinical condition means there is limited evidence regarding recommended treatment. Research into the efficacy of CFT and its suitability to target CPTSD’s symptom profile will contribute to the current gap in recommended treatment approaches for this condition.
Always Online: Abschalten in einer mobilen Arbeitswelt
Authors: Reinke Kathrin , Düvel Birte 
Published: July 2022

ZusammenfassungIn der heutigen mobilen Arbeitswelt verschwimmen Grenzen zwischen Arbeit und Privatleben immer mehr. Dies ist mit Vorteilen wie einer höheren Flexibilität verbunden. Auf der anderen Seite kann eine Entgrenzung der Arbeit langfristig zu Beeinträchtigungen der Gesundheit und der Leistungsfähigkeit führen. Grenzen zwischen Arbeits- und Privatleben aktiv zu gestalten, produktiv und gleichzeitig erholt zu bleiben, stellt somit eine große Herausforderung vieler Berufstätiger dar. Dieser Artikel fasst Ergebnisse aus der (Interventions‑)Forschung zur Grenzgestaltung und Erholung zusammen und zeigt Lösungsansätze für Beschäftigte und Organisationen auf, um dieser Herausforderung zu begegnen.
Warum beteiligen sich Coaches an Coaching-Forschung – und warum eigentlich nicht?
Authors: Hinn Denise , Kotte Silja , Möller Heidi 
Published: July 2022

ZusammenfassungIn einer Online-Umfrage befragten wir 252 Coaches und analysierten ihre Einstellung zur Coaching-Forschung, Faktoren, die ihre Einstellung beeinflussen, und wie sich ihre Haltung wiederum auf ihre Bereitschaft zur Teilnahme an Coaching-Forschung auswirkt. Die Faktorenanalyse ergab vier verschiedene Einstellungsfaktoren: (1) Mehrwert und (2) Schaden durch Coaching-Forschung, (3) Effektivitätszweifel, (4) Aufwand im Zusammenhang mit der Teilnahme an Coaching-Forschung. Die Erfahrung der Coaches (d. h. Novizen vs. Expert:innen; mit Coaching-Ausbildung vs. ohne) sagte die Einstellung zur Coaching-Forschung voraus, insbesondere für die Faktoren (2) und (3). Alle vier Faktoren sowie eine frühere Forschungsteilnahme sagten signifikant die Bereitschaft zur Teilnahme an Coaching-Forschung voraus.
Ergogenic value of oxygen supplementation in chronic obstructive pulmonary disease
Authors: Megaritis Dimitrios , Wagner Peter D. , Vogiatzis Ioannis 
Published: July 2022

AbstractPatients with COPD exhibit limited exercise endurance time compared to healthy age-matched individuals. Oxygen supplementation is often applied to improve endurance time during pulmonary rehabilitation in patients with COPD and thus a comprehensive understanding of the mechanisms leading to improved endurance is desirable. This review analyses data from two studies by our research group investigating the effect of oxygen supplementation on cerebrovascular, systemic, respiratory and locomotor muscle oxygen availability on the same cohort of individuals with advanced COPD, and the mechanisms associated with improved endurance time in hyperoxia, which was essentially doubled (at the same power output). In hyperoxia at isotime (the time at which patients became exhausted in normoxia) exercise was associated with greater respiratory and locomotor muscle (but not frontal cortex) oxygen delivery (despite lower cardiac output), lower lactate concentration and less tachypnoea. Frontal cortex oxygen saturation was higher, and respiratory drive lower. Hence, improved endurance in hyperoxia appears to be facilitated by several factors: increased oxygen availability to the respiratory and locomotor muscles, less metabolic acidosis, and lower respiratory drive. At exhaustion in both normoxia and hyperoxia, only cardiac output and breathing pattern were not different between conditions. However, minute ventilation in hyperoxia exceeded the critical level of ventilatory constraints (VE/MVV > 75–80%). Lactate remained lower and respiratory and locomotor muscle oxygen delivery greater in hyperoxia, suggesting greater muscle oxygen availability improving muscle function. Taken together, these findings suggest that central haemodynamic and ventilatory limitations and not contracting muscle conditions dictate endurance time in COPD during exercise in hyperoxia.
The Difference Between Ren and Yi: Mengzi’s Anti-Guodianism at 6A4-5
Authors: Brys Waldemar 
Published: July 2022

AbstractPassages from the recently excavated Guodian manuscripts bear a surprising resemblance to a position ascribed to Gaozi and his followers in theMengziat 6A4-5, namely that righteousness is “external.” Although such a resemblance has been noted, the philosophical implications of it for the debate between Gaozi and Mengzi and, by extension, for Mengzian ethics have been largely unexplored. I argue that a Guodian-inspired reading of 6A4-5 is one that takes the debate to be about whether standing in certain family relations makes a difference to whether one’s actions are righteous. Gaozi denies that it does, holding the view that one’s family relations, i.e., relationsinternalto the household, are irrelevant when it comes to matters of righteousness, while Mengzi disagrees, arguing that all relational properties, including family relations, are just as much reason-giving properties for performing righteous actions as they are in the case of performing benevolent actions. I argue that such a Guodian-based reading provides us a simple, yet explanatorily powerful reading of 6A4-5 that has broader implications for Mengzian ethics and our understanding of the early Chinese intellectual milieu in general.
The use of video essays and podcasts to enhance creativity and critical thinking in engineering
Authors: Caratozzolo Patricia , Lara-Prieto Vianney , Hosseini Samira , Membrillo-Hernández Jorge 
Published: July 2022

AbstractThe current demands of the labor market demand a new compendium of skills from engineering graduates. To develop skills at a more complex level, this study analyzed the use of second-generation Video Essays and Podcasts to improve soft skills. The characteristics of students belonging to Generation Z as digital natives were considered and digital platforms were adapted for interaction in social networks to enhance critical thinking and creativity (Criticality). Active learning experiences in different engineering programs were analyzed using the 4-group Solomon methodology with a quantitative design and different assessment instruments were used for Pre-Tests and Post-Tests, including various fluency and originality tests, as well as answering articulation ability tests. and modified VALUE rubrics from the Association of American Colleges and Universities (AAC&U). Our results clearly suggest that the use of these two tools substantially improves understanding of scientific concepts in engineering subjects, a greater ability to develop increasingly in-demand skill sets, and a greater awareness of creative thinking competence.
Multifocal Fibrosing Thyroiditis: an Under-recognized Mimicker of Papillary Thyroid Carcinoma
Authors: Orsatti Agnese , De Leo Antonio , Chiarucci Federico , Simoncini Giulia , Cremonini Nadia , Fornelli Adele , Amorosa Luca , Maloberti Thais , de Biase Dario , Tallini Giovanni 
Published: July 2022

AbstractMultifocal fibrosing thyroiditis (MFT) is an enigmatic entity, characterized by multiple fibrotic scar-like lesions with a paucicellular fibrotic center surrounded by a cellular peripheral area with reactive-appearing follicular cell atypia and variable chronic inflammation. Although poorly recognized and likely underreported in surgical pathology, the entity is considered rare with only 65 cases to date–including the current one reported to expand on the preoperative findings of this under-recognized entity. The average age of the patients is 46.8 years (range 15–71 years), 94% are female, with female to male ratio of 15:1. Individual MFT lesions typically have a superficial location. The average number of fibrotic lesions is 15.4 (range 2–51 per MFT case). Their average size is 3.1 mm (range 0.4–15.1). MFT is a disorder of diseased thyroids, typically found postoperatively in glands removed for other reasons, such as chronic lymphocytic/Hashimoto thyroiditis (32.3%), follicular nodular disease (nodular hyperplasia) (30.1%), hyperthyroidism/diffuse hyperplasia (Graves disease) (9.2%). Intriguing is the association with papillary thyroid carcinoma–present in 38.5% of MFT cases, and particularly with sub-centimetric and multifocal papillary thyroid carcinoma, with which MFT can be confused. Cases where MFT is the only thyroid pathology (7.7%) can be preoperatively mistaken for papillary thyroid carcinoma, due to worrisome ultrasound (US) and cytologic features, both of which are here documented for the first time as a component of this article. Wider recognition of MFT and of its cytologic and ultrasound features at preoperative evaluation may reduce unnecessary thyroidectomies.
Pyroptosis in inflammation-related respiratory disease
Authors: Feng Yuanyu , Li Min , Yangzhong Xiaoting , Zhang Xifeng , Zu Anju , Hou Yunjiao , Li Lin , Sun Shibo 
Published: July 2022

AbstractPyroptosis
is commonly induced by the gasdermin (GSDM) family and is accompanied by the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing evidence suggests that pyroptosis plays a role in respiratory diseases. This review aimed to summarize the roles and mechanisms of pyroptosis in inflammation-related respiratory diseases. There are several pathways involved in pyroptosis, such as the canonical inflammasome-induced pathway, non-canonical inflammasome-induced pathway, caspase-1/3/6/7/GSDMB pathway, caspase-8/GSDMC pathway, caspase-8/GSDMD pathway, and caspase-3/GSEME pathway. Pyroptosis may be involved in asthma, chronic obstructive pulmonary disease (COPD), lung cancer, acute lung injury (ALI), silicosis, pulmonary hypertension (PH), and tuberculosis (TB), in which the NLRP3 inflammasome-induced pathway is mostly highlighted. Pyroptosis contributes to the deterioration of asthma, COPD, ALI, silicosis, and PH. In addition, pyroptosis has dual effects on lung cancer and TB. Additionally, whether pyroptosis participates in cystic fibrosis (CF) and sarcoidosis or not is largely unknown, though the activation of NLRP3 inflammasome is found in CF and sarcoidosis. In conclusion, pyroptosis may play a role in inflammation-related respiratory diseases, providing new therapeutic targets.
Adsorption of methylene blue (MB) dye on ozone, purified and sonicated sawdust biochars
Authors: Eldeeb Tarek M. , Aigbe Uyiosa O. , Ukhurebor Kingsley E. , Onyancha Robert B. , El-Nemr Mohamed A. , Hassaan Mohamed A. , Ragab Safaa , Osibote Otolorin A. , El Nemr Ahmed 
Published: July 2022

Abstract
The synthesized biochars derived from sawdust (SD) SD ozone (SDO) biochar, purified SD (PSD) biochar, and sonicated SD (SSD) biochar, which was employed in the confiscation of methylene blue (MB) dye ion, were characterized employing “Brunauer–Emmett–Teller (BET), scanning electron microscope (SEM), Fourier Transform Infrared (FTIR), and Thermal gravimetrical analysis (TGA).” The impact of various factors, such as pH, biochar dosage, and initial concentration, on MB dye sequestration, was tested in this study. It was found that the biosorption of MB dye to the various biochars was dependent on the solution pH, with optimum confiscation of MB observed at pH 12 for all biochars. Pseudo-second-order (PSO), Freundlich (FRH)- (SDO and SSD biochars), and Langmuir (LNR)- (PSD biochar) models were used to best describe the biosorption process of MB dye to various biochars. Based on the LNR model fitting to the experimental data, the optimum sorption capacities obtained using SDO, SSD, and PSD biochars were 200, 526, and 769 mg/g, respectively. Electrostatic interaction and hydrogen bonding played an important role in the interaction mechanism between the various biochars and MB dye. Hence, these studied SDO, PSD, and SSD biochars prepared from cheap, easily accessible, biodegradable, and non-hazardous agro-waste materials can be effectively used for the removal, treatment, and management of MB dye as well as other industrial effluents before their disposal into the environment.
Clinical effectiveness of restorative materials for the restoration of carious primary teeth without pulp therapy: a systematic review
Authors: Amend S. , Boutsiouki C. , Bekes K. , Kloukos D. , Lygidakis N. N. , Frankenberger R. , Krämer N. 
Published: July 2022

Abstract
Purpose
To systematically search the available evidence and evaluate the clinical effectiveness of restorative materials for restoration of carious primary teeth. The findings aimed to support the European Academy of Paediatric Dentistry (EAPD) guidelines development.

Methods
Literature search was performed by searching 4 electronic databases for eligible randomised controlled clinical trials (RCTs) comparing restorative materials for the restoration of carious primary teeth up to December 28th, 2020. Quality assessment was performed with the revised Cochrane risk-of-bias tool for randomized trials (RoB 2).

Results
Of 1685 identified articles 29 RCTs were finally deemed as eligible for inclusion. Annual failure rates were: Amalgam 1–28%; atraumatic restorative treatment 1.2–37.1%; glass-ionomer cement (GIC) 7.6–16.6%, metal-reinforced GIC 29.9%, resin-modified GIC 1.9–16.9%, high-viscosity GIC 2.9–25.6%; glass carbomer ≤ 46.2%; compomer 0–14.7%; composite resin (CR) 0–19.5%, bulk-fill CR 0–16.9%; zirconia crowns 3.3%, composite strip crowns 15%, and preformed metal crowns (Hall-Technique) 3.1%. Secondary caries, poor marginal adaptation, loss of retention, and fracture of restoration were reported as reasons for failure. Four studies were evaluated at unclear and 25 at high risk of bias. Clinical and methodological heterogeneity, and the diversity of tested materials across included studies did not allow for meta-analyses.

Conclusions
Within the limitations of this systematic review, namely, the heterogeneity and the overall high risk of bias among included studies, clear recommendations based on solid evidence for the best restorative approach in primary teeth cannot be drawn. There is a need for future thoroughly implemented RCTs evaluating restorations in primary teeth to close this knowledge gap.
Reward Responsiveness, Learning, and Valuation Implicated in Problematic Pornography Use — a Research Domain Criteria Perspective
Authors: Klein Sanja , Krikova Kseniya , Antons Stephanie , Brand Matthias , Klucken Tim , Stark Rudolf 
Published: July 2022

Abstract
Purpose of Review
Problematic pornography use (PPU) describes a pattern of behavior characterized by excessive time spent using or thinking about pornography and continued use despite negative consequences. To help advance the understanding of transdiagnostic underlying psychological and neurobiological mechanisms in PPU, we aim to review existing evidence on these mechanisms focusing on positive valence systems within the transdiagnostic Research Domain Criteria (RDoC) framework.

Recent Findings
Reward anticipation processes seem to be increased in individuals with PPU symptoms when they anticipate sexual stimuli compared with other rewards. Studies further suggest that the initial neural and attentional responses to sexual rewards compared with different control stimuli are also increased in individuals with PPU symptoms, as are conditioned responses in sexual reward learning paradigms. Sexual reward valuation studies point towards an increased neural value differentiation with increasing PPU symptoms.

Summary
The current state of evidence indicates that positive valence systems are altered in persons with PPU. This framework of organizing evidence may aid in elucidating PPU development and maintenance as well as planning future studies.