bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design Optimization and Evaluation of Solid Lipid Nanoparticles of
Azelnidipine for the Treatment of Hypertension
Authors: Dugad Tejas , Kanugo Abhishek 
Published: October 2022

Background:
Solid lipid nanoparticles (SLN) are the most promising lipid-based drug delivery utilized for enhancing the solubility, bioavailability, and therapeutic efficacy of poorly water-soluble molecules. Azelnidipine (AZN) is a calcium channel blocker widely recommended for the treatment of high blood pressure but its activity is restricted due to high lipophilicity and poor solubility in the GIT. The current research focused on the development of the SLN of AZN and thereby improving the absorption, bioavailability, and therapeutic efficacy in hypertension which is a leading cause of death worldwide. Recent patents on SLN was available as U.S. Patent,10,973,798B2, U.S. Patent 10,251,960B2, U.S. Patent 2021/0069121A1, U.S. Patent 2022/0151945A1.

Methods:
SLN was developed by hot melt emulsification and ultrasonication method using glyceryl monostearate (GMS) as solid lipid and Poloxamer 188 as a surfactant for the stabilization of colloidal dispersion.

Results:
Box-Behnken model was utilized which predicted 13 batches in which concentration of GMS (X1), Poloxamer 188 (X2) and sonication time (X3) were considered as independent parameters. The particle size (Y1) and entrapment efficiency (Y2) were dependable parameters and optimized batch F2 showed a particle size of 166.4 nm, polydispersity index of 0.40 and zeta potential of -13.7 mV. The entrapment efficiency was observed at 86.21 %. FTIR spectra confirm the identity and compatibility with the formulation components. The differential scanning calorimetry (DSC) confirmed the absence of melting point and interpreted that AZN was entirely incorporated in the lipid matrix and transformed from crystalline to amorphous form. The ANOVA for the particle size (p-value: 0.0203), % EE (p-value: 0.0271) was found significant. The in-vitro drug release showed a sustained release pattern for about 12 h. The AZN-loaded SLN was lyophilized and intended for oral delivery.

Conclusion:
AZN-loaded SLN was developed by the hot melt emulsification method which accelerated the solubility and bioavailability and released in a sustained manner for treating hypertension.
Experimental Pharmacology for COVID-19 Treatment: A Geoanalytical
Bibliometric Analysis
Authors: Aguado Cesar , Castaño Victor M. 
Published: October 2022

Objective:
The objective of this study is to produce a geo-referenced map of the status
of R&D in COVID-related studies in the world.

Methods::
Spatial mapping of bibliometric data of Cortellis Drug Discovery Intelligence through an spatial bibliometric model with the aid of a GIS (Geographic Information System) called ArcGIS and the software.

Results:
We show the countries that have the most studies related to COV ID-19 and their degree
of collaboration. No drug discovery-related activity was found in South America and Africa. A
geo-referenced map of the most active countries in COVID research was constructed as well as
conceptual maps of the 11 most representative drugs employed for COVID treatment.

Conclusion:
The georeferenced conceptual maps produced in the present report allow not only to
better understand the leading institutions in R&D in COVID-19 related drugs but also to visualize
their interactions and research relationships. This could offer, in addition to a coherent, organized
multinational effort, the possibility of searching for other drugs that have been employed for other
diseases and that, in terms of their conceptual relations, could represent some possibilities for treating
the coronavirus SARS-2.
A Review on Polymeric Nanostructured Micelles for the Ocular
Inflammation-Main Emphasis on Uveitis
Authors: Kumar Manish , Kaushal Nikita , Singh Amanjot , Tiwari Abhishek , Tiwari Varsha , Pahwa Rakesh 
Published: October 2022

Background:
Various types of nano-formulations are being developed and tested for the
delivery of the ocular drug. They also have anatomical and physiological limitations, such as tear
turnover, nasal lachrymal waste, reflex squinting, and visual static and dynamic hindrances, which
pose challenges and delay ocular drug permeation. As a result of these limitations, less than 5% of
the dose can reach the ocular tissues.

Objective:
The basic purpose of designing these formulations is that they provide prolonged retention
for a longer period and can also increase the course time.

Methods:
To address the aforementioned issues, many forms of polymeric micelles were developed.
Direct dissolving, dialysis, oil-in-water emulsion, solvent evaporation, co-solvent evaporation,
and freeze-drying are some of the methods used to make polymeric nano micelles.

Results:
Their stability is also very good and also possesses reversible drug loading capacity.
When the drug is given through the topical route, then it has very low ocular bioavailability.

Conclusion:
The definition and preparation process of polymeric micelles and anti-inflammatory
drugs used in uveitis and the relation between uveitis and micelles are illustrated in detail.
Pulegone: An Emerging Oxygenated Cyclic Monoterpene Ketone
Scaffold Delineating Synthesis, Chemical Reactivity, and Biological
potential
Authors: Chopra Bhawna , Dhingra Ashwani K. 
Published: October 2022

Abstract:
Pulegone ((R)-5-Methyl-2-(1-methylethylidine) cyclohexanone) is a pharmacologically
active, natural monoterpene ketone obtained from leaves and flowering
tops of the mint family (Lamiaceae). The aim is to comprise the physicochemical and
biological aspects of pulegone. All significant databases were collected via electronic
search using Pubmed, Scopus, Web of Science, and Science Direct and were compiled.
This review presents the occurrence, chemistry, and modifications of pulegone structure
and its effect on the biological system. Pulegone represents various pharmacological
properties, i.e., antioxidant, antimicrobial, anti-feeding, antifungal, antiviral, and pesticide
activities, and has a significant role as an abortifacient and emmenagogue. Thus, this
present review concludes the knowledgeable erudition on pulegone that paves the way
for further work.
Expectations, Rejections, and Reviewer 2: Publishing Demystified
Authors: Lookingbill Valerie , Kitzie Vanessa , Winberry Joseph , Lund Brady , Colón-Aguirre Mónica , Hands Africa 
Published: October 2022

Navigating the pressures and processes of academic publishing is a challenge for doctoral students and recent graduates. While there is a growing expectation that doctoral students and recent graduates are capable of immediately producing publishable research and survive in a “publish or perish” environment, many doctoral students have misperceptions of and remain uncertain about how to navigate the publishing process (Rich, 2013). However, while the quantity of publications does not necessarily equate to success in the job market, publishing productivity is critical in finding employment (Hatch & Skipper, 2016). As such, doctoral students need to consider the publishing process early in their program so they can present a competitive publishing record when entering the job market. Yet, many universities do not provide formal training on understanding scholarly publishing or devote efforts to include explicit content on navigating the publishing process (Hanafizadeh & Shaikh, 2021). This panel from ALISE’s Doctoral Student Special Interest Group will therefore address this gap by presenting advice and strategies for doctoral students at any stage of their program, focusing on expectations of publishing as a doctoral student and best practices for publishing research. Panelists, comprised of early-career faculty and doctoral candidates with admirable publication records, will discuss their experiences with publishing, specifically through discussions of (1) expectations for publishing productivity as a doctoral student; (2) their decision-making processes about where to submit research for publication; (3) their strategies for publishing most efficiently; and (4) their experiences with publication rejections. Panelists will provide insight into the typical workflows of the publishing process, detail the most common pitfalls when submitting research for publication, and describe how to effectively address these pitfalls in manuscripts to minimize chances of receiving rejections. Drawing on the experiences of the panelists, attendees will learn of best practices for submitting research for publication and understand how to address fundamental issues and pitfalls of publishing to help increase their chances of getting their work published. Attendees will be able to ask questions and/or share their own experiences after panelists present through a moderated Q&A. The session will proceed as follows:
1. Welcome and introduction of panelists (5 minutes)
2. Panelist presentations on key topics (60 minutes)
3. Moderated Q&A (15 minutes)
4. Concluding thoughts (10 minutes)
LIS Leadership: Opportunities and Barriers for People of Color
Authors: Singh Vandana , Cooke Nicole , Rorissa Abebe , Hands Africa , Knox Emily 
Published: October 2022

Responding to the conference theme of “Go Back and Get It – From One Narrative to Many” this panel provides an opportunity for LIS faculty of color to voice their narratives about leadership opportunities in LIS. Through this panel, we will bring together people of color from different levels of LIS faculty (Assistant Professor, Associate Professor, and Professor) to discuss their expectations and experiences of opportunities and barriers in leadership positions in LIS. According to the latest ALISE Statistical report, 2021 (ALISE Statistical Report, 2021) – out of a total of 55 heads of schools in LIS, there are 34 white, 11 Asian, 2 Black, and 1 Native American and Hispanic. The representation of marginalized groups in LIS leadership remains minimal.
The panelists will discuss their experiences of being in leadership or administrative positions and the availability or lack of training and guidance for faculty of color. Panelists who have not been in leadership/administrative positions will discuss the hesitation and perceived barriers for this work. This panel will also create a platform for the faculty of color to assert their narrative, their interest, their ambitions, and their competence in leadership positions in LIS. Their stories with their reflections and illustrative examples will provide space for alternative narratives. Each panelist will give a 10 minute presentation and pose questions for audience engagement. Additionally, we will engage the audience to develop an agenda for future faculty leaders from marginalized groups. There will be a brainstorming and experience sharing session with the attending colleagues to discuss the following questions – What kind of barriers exist for POCs? How can we address these barriers? What are the systemic barriers that need to be removed by current leaders? What is the type of support that POC faculty needs to receive and succeed in leadership positions in LIS?
The panelists will solicit POC faculty to create a collaboration for developing leadership and administration training modules/toolkits for LIS faculty and doctoral students of color. This discussion will also explicate how this approach will be complementary to the current ALISE Leadership Academy. The goal is to spark dialogue between faculty and doctoral students of color to facilitate an equitable vision for the future. For the wider audience of the conference focused on the metaphorical meaning of Sankofa (ALISE 22 website), we hope that this discussion will provide a direction to “see” and “hear” the marginalized voices of people of color in LIS.
Educating for Equity
Authors: Villagran Michele , Hofman Darra 
Published: October 2022

This poster presentation summarizes mixed-methods research from the 2021 ALISE Research Grant Competition Award: Educating for Equity?: Sexual and Gender Minority Privacy in Library and Information Studies Education. This project examined whether we can handle complex information policy questions by examining an urgent information problem facing libraries: the privacy of sexual and gender minority (SGM) individuals in the face of COVID-19 surveillance. This session aligns with the conference theme by illustrating how “privacy” is a polysemous concept. Information professionals grappling with privacy from a policy perspective must be prepared for its multi-faceted nature and the distinct privacy needs of different communities. SGM face significant information risks that differ from those of cis-gender, heterosexual people; improper information disclosure can lead to the loss of employment, housing, access to health care, and social support for SGM due to outing. This study asked, “Are LIS programs preparing their students to meet the needs of LGBTQ+ patrons and stakeholders from a policy perspective in the workplace?” Researchers conducted a mixed methods study that included a survey of LIS faculty, a content analysis of ALA-approved masters programs’ learning outcomes and syllabi, a document analysis of the privacy policies of a sample of libraries, and interviews with library employers. The researchers will share any results to date from their analysis and provide current best practices and recommendations for both libraries and LIS educators to help expand the understanding of the privacy of marginalized groups.
Information Literacy is a Social Practice
Authors: Rath Logan 
Published: October 2022

The field of information literacy (IL) suffers from a gap between theory and practice, meaning that librarians, as practitioners, do not adequately use and apply the theory of information science in their work (Hider et al., 2019; Julien et al., 2013; Nguyen & Hider, 2018). Specifically, IL is theorized as a social practice, yet practitioners appear to adopt a skills-based approach to IL. As an answer to this theory-to-practice gap, a grounded theory study found that seeing information literacy as a social practice is a threshold concept for academic instruction librarians. This dissertation study employed focus groups and semi structured solicited diary prompts to explore the fit of this threshold concept with the experiences of academic librarians.
The central research question for this study was: To what extent, if any, does the proposed threshold concept describe librarians’ beliefs about information literacy as a social practice? Qualitative content analysis of the focus group transcripts and the diary entries found that the threshold concept required a slight revision in order to accurately describe librarians’ beliefs about information literacy as a social practice. Where the initial version of the threshold concept had one arrow indicating "tensions" that prevent librarians from teaching IL as a social practice, the revised version contains an opposing arrow indicating "supports" that help librarians to deliver IL from a social practice standpoint. The role of skills and practices in IL instruction were investigated. Findings from this study have implications for LIS educators, library administrators, and practicing academic instruction librarians.
Discovery and Analytical Validation of a Vocal Biomarker to Monitor Anosmia and Ageusia in Patients With COVID-19: Cross-sectional Study
Authors: Higa Eduardo , Elbéji Abir , Zhang Lu , Fischer Aurélie , Aguayo Gloria A , Nazarov Petr V , Fagherazzi Guy 
Published: October 2022

Background
The COVID-19 disease has multiple symptoms, with anosmia and ageusia being the most prevalent, varying from 75% to 95% and from 50% to 80% of infected patients, respectively. An automatic assessment tool for these symptoms will help monitor the disease in a fast and noninvasive manner.

Objective
We hypothesized that people with COVID-19 experiencing anosmia and ageusia had different voice features than those without such symptoms. Our objective was to develop an artificial intelligence pipeline to identify and internally validate a vocal biomarker of these symptoms for remotely monitoring them.

Methods
This study used population-based data. Participants were assessed daily through a web-based questionnaire and asked to register 2 different types of voice recordings. They were adults (aged >18 years) who were confirmed by a polymerase chain reaction test to be positive for COVID-19 in Luxembourg and met the inclusion criteria. Statistical methods such as recursive feature elimination for dimensionality reduction, multiple statistical learning methods, and hypothesis tests were used throughout this study. The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis) Prediction Model Development checklist was used to structure the research.

Results
This study included 259 participants. Younger (aged <35 years) and female participants showed higher rates of ageusia and anosmia. Participants were aged 41 (SD 13) years on average, and the data set was balanced for sex (female: 134/259, 51.7%; male: 125/259, 48.3%). The analyzed symptom was present in 94 (36.3%) out of 259 participants and in 450 (27.5%) out of 1636 audio recordings. In all, 2 machine learning models were built, one for Android and one for iOS devices, and both had high accuracy—88% for Android and 85% for iOS. The final biomarker was then calculated using these models and internally validated.

Conclusions
This study demonstrates that people with COVID-19 who have anosmia and ageusia have different voice features from those without these symptoms. Upon further validation, these vocal biomarkers could be nested in digital devices to improve symptom assessment in clinical practice and enhance the telemonitoring of COVID-19–related symptoms.

Trial Registration
Clinicaltrials.gov NCT04380987; https://clinicaltrials.gov/ct2/show/NCT04380987
Assessing the Content and Quality of Digital Tools for Managing Gestational Weight Gain: Systematic Search and Evaluation
Authors: Brammall Bonnie R , Garad Rhonda M , Boyle Jacqueline A , Hayman Melanie J , de Jersey Susan J , Teede Helena J , Hong Quoc V , Carrandi Alayna , Harrison Cheryce L 
Published: October 2022

Background
Digital health resources have the potential to assist women in optimizing gestational weight gain (GWG) during pregnancy to improve maternal health outcomes.

Objective
In this study, we aimed to evaluate the quality and behavior change potential of publicly available digital tools (websites and apps) that facilitate GWG tracking.

Methods
Digital tools were identified using key search terms across website search engines and app stores and evaluated using the Mobile App Rating Scale, the App Behavior Change Scale, as well as criteria to evaluate the rigor and safety of GWG information.

Results
Overall, 1085 tools were screened for inclusion (162 websites and 923 apps), and 19 were deemed eligible. The mean Mobile App Rating Scale quality score was 3.31 (SD 0.53) out of 5, ranging from 2.26 to 4.39, and the mean App Behavior Change Scale score was 6 (SD 3.4) out of 21, ranging from 19 to 0. Of the 19 items used to evaluate rigor of GWG advice, most tools (n=11, 57.9%) contained ≤3 items.

Conclusions
This review emphasizes the substantial limitations in current digital resources promoting the monitoring and optimization of GWG. Most tools were of low quality, had minimal behavior change potential, and were potentially unsafe, with minimal linkage to evidence-based information or partnership with health care.
The Use of Technology to Provide Mental Health Services to Youth Experiencing Homelessness: Scoping Review
Authors: Lal Shalini , Elias Sarah , Sieu Vida , Peredo Rossana 
Published: October 2022

Background
There is growing interest in using information and communication technologies (ICTs) to improve access to mental health services for youth experiencing homelessness (YEH); however, limited efforts have been made to synthesize this literature.

Objective
This study aimed to review the research on the use of ICTs to provide mental health services and interventions for YEH.

Methods
We used a scoping review methodology following the Arksey and O’Malley framework and guidelines from the Joanna Briggs Institute Manual for Evidence Synthesis. The results are reported according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). A systematic search was conducted from 2005 to 2021 in MEDLINE, Embase, CINAHL, PsycInfo, Cochrane, Web of Science, and Maestro and in ProQuest Thesis and Dissertations, Papyrus, Homeless Hub, and Google Scholar for gray literature. Studies were included if participants’ mean age was between 13 and 29 years, youth with mental health issues were experiencing homelessness or living in a shelter, ICTs were used as a means of intervention, and the study provided a description of the technology. The exclusion criteria were technology that did not allow for interaction (eg, television) and languages other than French or English. The data were analyzed using descriptive statistics and qualitative approaches. Two reviewers were involved in the screening and data extraction process in consultation with a third reviewer. The data were summarized in tables and by narrative synthesis.

Results
From the 2153 abstracts and titles screened, 12 were included in the analysis. The most common types of ICTs used were communication technologies (eg, phone, video, and SMS text messages) and mobile apps. The intervention goals varied widely across studies; the most common goal was reducing risky behaviors, followed by addressing cognitive functioning, providing emotional support, providing vital resources, and reducing anxiety. Most studies (9/11, 82%) focused on the feasibility of interventions. Almost all studies reported high levels of acceptability (8/9, 89%) and moderate to high frequency of use (5/6, 83%). The principal challenges were related to technical problems such as the need to replace phones, issues with data services, and phone charging.

Conclusions
Our results indicate the emerging role of ICTs in the delivery of mental health services to YEH and that there is a high level of acceptability based on early feasibility studies. However, our results should be interpreted cautiously, considering the limited number of studies included in the analysis and the elevated levels of dropout. There is a need to advance efficacy and effectiveness research in this area with larger and longer studies.

International Registered Report Identifier (IRRID)
RR2-10.1136/bmjopen-2022-061313