bluuebunny/crossref_metadata_2025_split huggingface dataset:
Animal linguistics: a primer
Authors: Berthet Mélissa , Coye Camille , Dezecache Guillaume , Kuhn Jeremy 
Published: October 2022

ABSTRACTThe evolution of language has been investigated by several research communities, including biologists and linguists, striving to highlight similar linguistic capacities across species. To date, however, no consensus exists on the linguistic capacities of non‐human species. Major controversies remain on the use of linguistic terminology, analysis methods and behavioural data collection. The field of ‘animal linguistics’ has emerged to overcome these difficulties and attempt to reach uniform methods and terminology. This primer is a tutorial review of ‘animal linguistics’. It describes the linguistic concepts of semantics, pragmatics and syntax, and proposes minimal criteria to be fulfilled to claim that a given species displays a particular linguistic capacity. Second, it reviews relevant methods successfully applied to the study of communication in animals and proposes a list of useful references to detect and overcome major pitfalls commonly observed in the collection of animal behaviour data. This primer represents a step towards mutual understanding and fruitful collaborations between linguists and biologists.
Ant diversity decreases during the dry season: A meta‐analysis of the effects of seasonality on ant richness and abundance
Authors: Queiroz Antônio C. M. , Marques Tatianne G. , Ribas Carla R. , Cornelissen Tatiana G. , Nogueira Anselmo , Schmidt Fernando A. , Feitosa Rodrigo M. , Sobrinho Tathiana G. , Quinet Yves , Baccaro Fabrício B. , Ulysséa Mônica A. , Vargas André B. , Morini Maria Santina C. , Souza Jorge L. P. , Paolucci Lucas N. , Dáttilo Wesley , Del‐Claro Kleber , Lange Denise , Santos Jean C. , Silva Rogério R. , Campos Renata B. F. , Albuquerque Emília Z. , Izzo Thiago , Rabello Ananza M. , Solar Ricardo R. C. , Soares Stela A. , Carvalho Karine S. , Moraes Aline B. , Torezan‐Silingardi Helena M. , Nahas Larissa , dos Santos Iracenir Andrade , Costa‐Milanez Cinthia B. , Esteves Flávia , Frizzo Tiago , Harada Ana Y. , DaRocha Wesley , Diehl‐Fleig Eduardo 
Published: October 2022

AbstractTropical studies traditionally describe insect diversity variation throughout the year. The temporally structured responses of insect assemblages to climate seasonality vary across ecosystems due to gradients of resource availability and limiting ecological factors. These idiosyncratic responses might be particularly true across the vast geographical range of the Brazilian territory, including various environments that harbor one of the most diverse ant faunas worldwide. This study addressed the relationship between ant diversity and climatic seasonality, performing a quantitative review of the published data on ant diversity collected in Brazil. We investigated the seasonality effect on ant abundance and richness described in the literature in 47 papers published between 2000 and 2018. These studies were developed mainly in the Atlantic Forest biome and collected ants with pitfall traps on the soil/litter stratum. We initially carried out a vote‐counting procedure by comparing the number of significant results describing seasonal differences in the ant assemblage. We found that most papers described a similar pattern of ant abundance, richness, and species composition between seasons. However, when we performed a meta‐analysis, we observed a clear pattern of higher ant abundance and richness in the wet/summer season compared with the dry/winter season. Our meta‐analysis reveals that the ant diversity decreases in the dry season, strongly in the Cerrado biome. Additionally, we point out differences in the sampling effort across biomes, indicating the need for further investments in studies focused on temporal diversity patterns, including seasonal effects, on the insect assemblage in biomes less investigated so far.Abstract in Portuguese is available with online material.
Changes in implant stability using different site preparation techniques: Osseodensification drills versus piezoelectric surgery. A multi‐center prospective randomized controlled clinical trial
Authors: Stacchi Claudio , Troiano Giuseppe , Montaruli Graziano , Mozzati Marco , Lamazza Luca , Antonelli Alessandro , Giudice Amerigo , Lombardi Teresa 
Published: October 2022

AbstractIntroductionImplant stability is influenced by bone density, implant design, and site preparation characteristics. Piezoelectric implant site preparation (PISP) has been demonstrated to improve secondary stability compared with conventional drilling techniques. Osseodensification drills (OD) have been recently introduced to enhance both bone density and implant secondary stability. The objective of the present multi‐center prospective randomized controlled trial was to monitor implant stability changes over the first 90 days of healing after implant bed preparation with OD or PISP.MethodsEach patient received two identical, adjacent or contralateral implants in the posterior maxilla. Following randomization, test sites were prepared with OD and control sites with PISP. Resonance frequency analysis was performed immediately after implant placement and after 7, 14, 21, 28, 60, and 90 days. Implants were then restored with single screw‐retained metal‐ceramic crowns and followed for 12 months after loading.ResultsTwenty‐seven patients (15 males and 12 females; mean age 63.0 ± 11.8 years) were included in final analysis. Each patient received two identical implants in the posterior maxilla (total = 54 implants). After 1 year of loading, 53 implants were satisfactorily in function (one failure in test group 28 days after placement). Mean peak insertion torque (40.7 ± 12.3 Ncm and 39.5 ± 10.2 Ncm in test and control group, respectively) and mean implant stability quotient (ISQ) value at baseline (71.3 ± 6.9 and 69.3 ± 7.6 in test and control group, respectively) showed no significant differences between the two groups. After an initial slight stability decrease, a shift to increasing ISQ values occurred after 14 days in control group and after 21 days in test group, but with no significant differences in ISQ values between the two groups during the first 90 days of healing.ConclusionNo significant differences in either primary or secondary stability or implant survival rate after 1 year of loading were demonstrated between implants inserted into sites prepared with OD and PISP.
Two‐piece zirconia implants in the posterior mandible and maxilla: A cohort study with a follow‐up period of 9 years
Authors: Brunello Giulia , Rauch Nicole , Becker Kathrin , Hakimi Ahmad R. , Schwarz Frank , Becker Jürgen 
Published: October 2022

AbstractObjectivesLong‐term follow‐up observations of zirconia implants are rare. This study aimed at evaluating the clinical performance of two‐piece zirconia implants in the posterior jaws over 9 years.Materials and MethodsSixty partially edentulous patients were treated with two‐piece zirconia implants. In eight no primary stability could be achieved. Fifty‐two patients received the final restoration (i.e., cemented fibreglass abutments and all‐ceramic crowns). After 2 years, 2 implants failed and 4 dropouts were recorded. The remaining 46 patients with one target implant each were recalled at 9 years. Besides implant survival, clinical parameters at the implant level (plaque index–PI, bleeding on probing–BOP, probing depth–PD, mucosal recession–MR) were recorded and compared with previously collected data. Mechanical and technical complications were assessed.ResultsThirty patients responded. The mean observation period was of 111.1 ± 2.2 months. One implant was lost. Data recorded from the remaining 29 implants were analysed. PI values increased overtime. Mean BOP and PD remained unchanged during follow‐up. No additional cases of peri‐implantitis were recorded over the 10 diagnosed during the first 2 years of follow‐up. No significant changes in mean MR values were detected over time, with 65% of the all included implants exhibiting no recession at 9 years and all the others, but one, a maximum MR of 1 mm. Three technical and 6 mechanical complications occurred in 7 patients between 2‐ and 9‐years (6.9% and 20.7%, respectively, at patient level).ConclusionWithin the limitations of the present study, a high survival rate was registered. Albeit frequent mechanical and technical complications, two‐piece zirconia implants could represent a valid solution for the replacement of single teeth in the posterior jaws.
Ferroptosis contributes to hypoxic–ischemic brain injury in neonatal rats: Role of the SIRT1/Nrf2/GPx4 signaling pathway
Authors: Li Chang , Wu Ziyi , Xue Hang , Gao Qiushi , Zhang Yahan , Wang Changming , Zhao Ping 
Published: October 2022

AbstractAimsHypoxic–ischemic brain injury (HIBI) often results in cognitive impairments. Herein, we investigated the roles of ferroptosis in HIBI and the underlying signaling pathways.MethodsFerrostatin‐1 (Fer‐1) or resveratrol (Res) treatments were administered intracerebroventricularly 30 min before HIBI in 7‐day‐old rats. Glutathione peroxidase 4 (GPx4) expression, malondialdehyde (MDA) concentration, iron content, mitochondrial morphology, and the expression of silent information regulator factor 2‐related enzyme 1 (SIRT1) and nuclear factor erythroid‐2‐related factor 2 (Nrf2) were measured after HIBI. Additionally, the weight ratio of left/right hemisphere, brain morphology, Nissl staining, and the Morris water maze test were conducted to estimate brain damage.ResultsAt 24‐h post‐HIBI, GPx4 expression was decreased, and MDA concentration and iron content were increased in the hippocampus. HIBI led to mitochondrial atrophy, brain atrophy/damage, and resultant learning and memory impairments, which were alleviated by Fer‐1‐mediated inhibition of ferroptosis. Furthermore, Res‐mediated SIRT1 upregulation increased Nrf2 and GPx4 expression, thereby attenuating ferroptosis, reducing brain atrophy/damage, and improving learning and memory abilities.ConclusionThe results demonstrated that during HIBI, ferroptosis occurs via the SIRT1/Nrf2/GPx4 signaling pathway, suggesting it as a potential therapeutic target for inhibiting ferroptosis and ameliorating HIBI‐induced cognitive impairments.
Altered functional connectivity of nucleus accumbens subregions associates with non‐motor symptoms in Parkinson's disease
Authors: Chen Lili , Wang Junling , Xia Mingrui , Sun Lianglong , Sun Junyan , Gao Linlin , Zhang Dongling , Wu Tao 
Published: October 2022

AbstractAimsThis study aimed to identify the functional connectivity (FC) changes of nucleus accumbens (NAc) subregions and characterize the association of network changes and non‐motor symptoms (NMS) in Parkinson's disease (PD).MethodsWe enrolled 129 PD patients and 106 healthy controls from our center and the PPMI (Parkinson's Progression Markers Initiative) database. The FC of the bilateral core and shell of the NAc were measured and compared between the two groups. We further used partial least squares correlation to reveal the relationships between altered FC of NAc subregions and manifestations of NMS of PD.ResultsThe subregions of left core, left shell, and right core had reduced FC with extensive brain regions in PD patients compared with healthy controls. These three subregions were commonly associated with depression, anxiety, apathy, and cognitive impairment. Moreover, the left core and left shell were associated with excessive daytime sleepiness, whereas the right core was associated with olfactory impairment and rapid eye movement sleep behavior disorder.ConclusionThis study for the first time identified the neural network changes of NAc subregions in PD and the associations between network changes and phenotypes of NMS. Our findings provide new insights into the pathogenesis of NMS in PD.
Features of circumference sizes in women of different constitutional groups
Authors: Nuruev Mirlan , Sakibaev Kyialbek , Dzholdosheva Gulay , Maksimova Kanyshai , Kanymgul Asanbek kyzy 
Published: October 2022

AbstractIntroductionThe constitution of a person determines their physical condition and the level of metabolism in the body. For this reason, the characteristic of a person's somatotype (body type) is important for assessing their health and is used to determine the norm of physical development. The purpose of this study was to investigate and compare the features of circumference sizes in women of the Kyrgyz Republic with different body types and age groups.MethodsA total of 1028 healthy women aged 16–55 years living in the city of Osh and its suburbs were examined. Physical development was assessed using the method of complex anthropometry and somatotyping.ResultsThe mesosomal and megalosomal groups are more common in women of the third age category, while in the leptosomal group, the number of women of different age categories was approximately the same. In women aged 21–35 years old, the average value of the chest circumference index was 1.1 times greater than in girls aged 16–20 years old, the waist circumference was 1.1 times greater and the gluteal circumference was also more than 1.03 times greater. In women of the third age category, the above indicators increase by 1.09, 1.09 and 1.05 times, respectively, in comparison with girls from the first category.ConclusionThe analysis of somatotypes and circumference sizes of Kyrgyz women of different ages suggests that there is a relative dependence of the measured parameters on the age and constitution of the body.
Afatinib triggers a Ni2+‐resistant Ca2+ influx pathway in A549 non‐small cell lung cancer cells
Authors: Tsai Tien‐Yao , Chen Cing‐Yu , Shiao Lian‐Ru , Ou Ting‐Tsz , Wu Cheng‐Hsun , Leung Yuk‐Man , Chow Louis W. C. 
Published: October 2022

AbstractAfatinib is used to treat non‐small cell lung cancer cells (NSCLC), and its mechanism involves irreversible inhibition of epidermal growth factor receptor (EGFR) tyrosine kinase. In this study, we examined if afatinib had cytotoxic action against NSCLC other than inhibition of tyrosine kinase. Afatinib (1–30 μM) caused apoptotic death in A549 NSCLC in a concentration‐dependent manner. Afatinib triggered Ca2+ influx without causing Ca2+ release, and the Ca2+ influx was unaffected by sodium orthovanadate (SOV, an inhibitor of tyrosine phosphatase), suggesting that afatinib‐triggered Ca2+ response was unrelated to its inhibition of tyrosine kinase. Addition of afatinib also promoted Mn2+ influx. Ca2+ influx triggered by afatinib was resistant to SKF96365 and ruthenium red (two general blockers of TRP channels) and, unexpectedly, Ni2+ (a non‐specific Ca2+ channel blocker). Afatinib caused an increase in mitochondrial Ca2+ level, an initial mitochondrial hyperpolarization (4 h) and followed by mitochondrial potential collapse (24–48 h). Afatinib‐induced cell death was slightly but significantly alleviated in low extracellular Ca2+ condition or under pharmacological block of mitochondrial permeability transition pore (MPTP) opening by cyclosporin A. Therefore, in addition to tyrosine kinase inhibition as a major anti‐cancer mechanism of afatinib, stimulation of an atypical Ca2+ influx pathway, mitochondrial Ca2+ overload, and potential collapse in part contribute to afatinib‐induced cell death.
Workplace violence against Bangladeshi registered nurses: A survey following a year of the COVID‐19 pandemic
Authors: Chowdhury Saifur Rahman , Kabir Humayun , Das Dipak Chandra , Chowdhury Mahfuzur Rahman , Chowdhury Mahmudur Rahman , Hossain Ahmed 
Published: October 2022

AbstractAimsTo investigate the prevalence of workplace violence and its associated factors among Bangladeshi registered nurses.BackgroundWorkplace violence is prevalent among nurses, particularly in developing countries. However, the issue has never been examined in Bangladeshi nurses.MethodsBetween February 26 and July 10, 2021, this cross‐sectional survey involving 1264 registered nurses was conducted. Workplace violence was determined by the Workplace Violence Scale (WVS). A multivariable logistic regression model was fitted to find the factors associated with workplace violence. This study complies with the EQUATOR (STROBE) checklist.ResultsOf the 1264 nurses, 885 (70%) nurses reported being exposed to workplace violence in the previous year. Three hundred twenty‐four (324; 25.6%) nurses reported physical violence, whereas 902 (71.4%) nurses reported nonphysical violence. According to the multivariable logistic regression model, male nurses, nurses in the Sylhet division, emergency department nurses, nurses working extended hours, and non trained nurses to tackle workplace violence were prone to physical violence. Furthermore, public hospital nurses and non trained nurses to tackle workplace violence were more likely to be exposed to nonphysical violence. Nurses who had not been exposed to workplace violence were satisfied with their current job, but those who had been exposed to workplace violence were dissatisfied and intended to leave their current job.Conclusions and implications for nursing and health policyHigh prevalence of workplace violence underscores nurses’ current working conditions, which are particularly poor in public hospitals and emergency departments. Moreover, the COVID‐19 pandemic put unprecedented pressure on the whole healthcare system and caused various difficulties for healthcare workers. To develop a zero‐violence practice environment, health authorities should implement policy‐level interventions. Healthcare staff should be guided to deal more successfully with patients and coworkers to create a positive working environment.
Is there a Common Digital Market in the European Union? Implications for the European Digitalization Strategy
Authors: Gomes Ana , Dias José G. 
Published: October 2022

AbstractDue to the impact of the COVID‐19 pandemic, people has changed the way they work, learn and socialize. As result, it is important to identify the pre‐existing digital gaps to implement the European Union digitalization strategy. This study aims to identify typologies of internet use in the 28 European Union (EU) countries (at the time of the survey), based on the characteristics of the users and their internet usage patterns. A two‐level latent class analysis was applied. At the first level, individuals within each country were grouped according to their characteristics of internet use; and, simultaneously, at the second level, countries were grouped based on the similar structure of individual segments. Using data from Eurobarometer, results show that internet use in the EU digital market is not homogeneous. The European Commission should take these pre‐existing gaps into account in the EU digitalization strategy.
Mitochondrial dysfunction: The pathological link between psoriasis and insulin resistance?
Authors: Villarreal‐Martinez Alejandra , Martinez‐de‐Villarreal Laura Elia , Gomez‐Flores Minerva , Chavez‐Alvarez Sonia , Cerda‐Flores Ricardo , Ocampo‐Candiani Jorge , Ruiz‐Herrera Consuelo , Rodriguez‐Rivera Marcelo R. , Villarreal‐Perez Jesús Zacarías , Gonzalez‐Gonzalez José Gerardo , Calvo‐Anguiano Geovana 
Published: October 2022

AbstractBackgroundPsoriasis is strongly associated with insulin resistance (IR). Lipid profile disturbances and upregulation of enzymes crucial for fatty acid oxidation have been reported in patients with psoriasis. Mitochondrial ß‐oxidation is altered in patients with IR. Common mitochondrial dysfunction may be involved in the origin of both diseases.ObjectiveThis study aimed to evaluate mitochondrial ß‐oxidation, intermediary metabolism, and mitochondrial content in psoriatic patients with or without IR and compare them to healthy controls.MethodsThe participants were divided into three groups: (1) psoriasis and IR (n = 26); (2) psoriasis without IR (n = 17); and (3) healthy controls (n = 17). Quantification of amino acids and acylcarnitines (AC) by tandem mass spectrometry, determination of urinary organic acids by gas chromatography/mass spectrometry (GC/MS), and mitochondrial DNA quantification were performed in all groups.ResultsWhen comparisons were made between the two psoriatic groups, no differences were found between: C5DC + C6OH, C16:1, Met/Leu, Met/Phe, C16:1/C16, and C5DC + C6OH/C4DC + C5OH ratios. Nine analytes were different: phenylalanine, Cit/Phe, and Cit/Tyr ratios, C0, C3, C5, C6DC, C16, and C18:1OH. There were no correlations between psoriasis area and severity index (PASI), body mass index (BMI) and duration of disease with ACs. A higher proportion of patients with psoriasis showed increased urine levels of uric acid and hippuric acid (p = 0.01). The mtDNA content was significantly higher in cases than in controls, with no differences between IR and non‐IR psoriatic patients.ConclusionsPsoriasis patients with and without IR have a different acylcarnitine profile reflecting impaired ß‐oxidation. A distinctive profile of acylcarnitines suggests an involvement of mitochondrial function associated with an increase in stearoyl CoA desaturase (SCD) activity in psoriatic patients with and without IR.
Linked color imaging provides enhanced visibility with a high color difference in upper gastrointestinal neoplasms
Authors: Dohi Osamu , Ono Shoko , Kawada Kenro , Kitamura Shinji , Hatta Waku , Hori Shinichiro , Kanzaki Hiromitsu , Murao Takahisa , Yagi Nobuaki , Sasaki Fumisato , Hashiguchi Keiichi , Oka Shiro , Katada Kazuhiro , Shimoda Ryo , Mizukami Kazuhiro , Suehiro Mitsuhiko , Takeuchi Toshihisa , Katsuki Shinichi , Tsuda Momoko , Naito Yuji , Kawano Tatsuyuki , Haruma Ken , Ishikawa Hideki , Mori Keita , Kato Mototsugu ,   LCI‐FIND TRIAL Group
Published: October 2022

AbstractBackground and AimThe aim of this post‐hoc analysis in a randomized, controlled, multicenter trial was to evaluate the visibility of upper gastrointestinal (UGI) neoplasms detected using linked color imaging (LCI) compared with those detected using white light imaging (WLI).MethodsThe visibility of the detected UGI neoplasm images obtained using both WLI and LCI was subjectively reviewed, and the median color difference (ΔE) between each lesion and the surrounding mucosa according to the CIE L*a*b* color space was evaluated objectively. Multivariate logistic regression analysis was performed to identify factors associated with neoplasms that were missed under WLI and detected under LCI.ResultsA total of 120 neoplasms, including 10, 32, and 78 neoplasms in the pharynx, esophagus, and stomach, respectively, were analyzed in this study. LCI enhanced the visibility 80.9% and 93.6% of neoplasms in pharynx/esophagus and stomach compared with WLI, respectively. LCI also achieved a higher ΔE of enhanced neoplasms compared with WLI in the pharynx/esophagus and stomach. The median WLI ΔE values for gastric neoplasms missed under WLI and later detected under LCI were significantly lower than those for gastric neoplasms detected under WLI (8.2 vs 9.6, respectively). Furthermore, low levels of WLI ΔE (odds ratio [OR], 7.215) and high levels of LCI ΔE (OR, 22.202) were significantly associated with gastric neoplasms missed under WLI and later detected under LCI.ConclusionColor differences were independently associated with missing gastric neoplasms under WLI, suggesting that LCI has an obvious advantage over WLI in enhancing neoplastic visibility.