bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aufgabenübertragung ärztlicher Tätigkeiten in
der Versorgung von Menschen mit Demenz auf Pflegefachpersonen in Substitution
und Delegation
Authors: Henning Esther , Rädke Anika , Michalowsky Bernhard , Lücker Petra , Biedenweg Bianca , Buchholz Maresa , Drewelow Eva , Wollny Anja , Zorn Daniela , Altiner Attila , Oppermann Roman F. , Kohlmann Thomas , Hoffmann Wolfgang 
Published: March 2022

Zusammenfassung
Hintergrund Seit etwa 15 Jahren wird eine Übertragung
ärztlicher Tätigkeiten an Pflegefachpersonen und damit eine
Aufgabenneuverteilung zwischen beiden Professionen diskutiert. Für
Modellvorhaben wurde bereits eine rechtliche Grundlage geschaffen. Jedoch fehlen
bis heute klar definierte Tätigkeiten. Ziel der AHeaD-Studie war es, die
Meinungen von Hausärzt*innen, Pflegefachpersonen, Menschen mit
Demenz (MmD) und deren Angehörigen zur Möglichkeit der
Substitution und Delegation spezifischer ärztlicher Tätigkeiten
durch Pflegefachpersonen und ihrer Akzeptanz in der ambulanten Demenzversorgung
zu erfassen.
Methodik Durchgeführt wurde eine Mixed-Methods-Studie mit einem
sequentiellen Vertiefungsdesign. Die hier vorgestellte Auswertung bezieht sich
auf die quantitative Befragung der vier Teilnehmer*innengruppen. Es
wurden 865 Teilnehmer*innen zur Akzeptanz der Substitution von
Assessments, Primär- und Folgeverschreibungen, Maßnahmen des
gesundheitlichen Monitorings und weiteren, bislang ausschließlich
ärztlichen Tätigkeiten befragt.
Ergebnisse Über alle Probandengruppen hinweg erzielten das
Assessment von Mobilitätseinschränkungen, der Alltagskompetenz
und von Ernährungsauffälligkeiten, die Verschreibung von
Fahrtdiensten, Pflegehilfsmitteln und häuslicher Krankenpflege sowie die
Durchführung von Blutentnahmen die höchste Zustimmung zur
Substitution. MmD und Angehörige gaben durchweg eine sehr hohe Akzeptanz
der Substitution an, wobei Hausärzt*innen auch bei einer
Substitution von Tätigkeiten weiterhin erste*r
Ansprechpartner*in blieben (88%). Bei den
Hausärzt*innen (63,2%) war im Vergleich zu den
Pflegefachpersonen (56,7%) im Mittel die Akzeptanz der Substitution
höher.
Schlussfolgerung Ein Großteil der Hausärzt*innen,
Pflegefachpersonen, MmD und Angehörigen begrüßte eine
Substitution ärztlicher Tätigkeiten. Dabei stehen MmD und
Angehörige einer Substitution deutlich positiver gegenüber.
Virale anteriore Uveitis
Authors: Baquet-Walscheid Karoline , Pohlmann Dominika , Pleyer Uwe 
Published: March 2022

ZusammenfassungVirale anteriore Uveitiden (AU) lassen sich anhand der charakteristischen Befundkonstellationen (Vorderkammerreiz, Morphologie der Keratopräzipitate, Ausmaß des IOD-Anstiegs im Schub) oft
gut klinisch differenzieren. Bei differenzialdiagnostischen Schwierigkeiten hilft die Vorderkammerpunktion mit Durchführung einer virusspezifischen PCR und/oder die Antikörperbestimmung
(Goldmann-Witmer-Koeffizient), wobei beide Techniken spezifisch sind, aber keine absolute Sensitivität besitzen. Therapiert wird bei HSV, VZV und CMV immer kombiniert antiviral und
antiinflammatorisch sowie ggf. drucksenkend, wohingegen für die Rubella-assoziierte AU kein spezifisches Virustatikum existiert und Steroide aufgrund der unerwünschten Wirkungen äußerst
zurückhaltend eingesetzt werden sollten. Problematisch bei allen Formen der viralen AU ist das Risiko der Sekundärglaukomentwicklung im Falle rezidivierender Episoden, das nicht selten
operativ behandelt werden muss.
Zielgerichtete Anamnese und Diagnostik bei Uveitis
Authors: Grajewski Rafael S. , Tappeiner Christoph , Thurau Stephan 
Published: March 2022

ZusammenfassungUveitis ist ein Sammelbegriff für eine Vielzahl unterschiedlicher intraokularer Entzündungen. Dabei variieren die zugrunde liegenden Ätiologien sehr stark in Abhängigkeit vom Subtyp der
Uveitis, vor allem vom anatomischen Schwerpunkt. Die Hauptformen der anterioren Uveitis stellen die akute fibrinöse unilaterale Verlaufsform, häufig mit dem HLA-B27-Haplotyp assoziiert, und
die granulomatöse Entzündung, typischerweise im Zusammenhang mit einer Sarkoidose oder einer Herpesinfektion, dar. Die intermediäre Uveitis ist meistens idiopathischer Natur, kann jedoch
auch mit einer Multiplen Sklerose oder einer Sarkoidose assoziiert sein, während bei Patienten nach dem 45. Lebensjahr auch an ein vitreoretinales Lymphom als Masquerade-Syndrom gedacht
werden muss. Die Uveitis posterior wiederum, und ähnlich auch die retinale Vaskulitis und Panuveitis, haben eine sehr breite ätiologische Vielfalt, die aber ebenso befundorientiert
eingegrenzt werden kann. So haben Retinitiden häufig eine infektiöse Genese (Toxoplasma und Viren der Herpesgruppe), während es sich bei Chorioiditiden häufig um spezifische, vermutlich
autoimmune Entitäten handelt, wobei auch hier Infektionen, z. B. Tuberkulose, zugrunde liegen können. Anamnese und Labordiagnostik sollten bei Patienten mit Uveitis daher maßgeschneidert und
orientiert am anatomischen Schwerpunkt der Entzündung (Uveitis anterior, intermedia, posterior oder Panuveitis) und dem klinischen Bild (z. B. granulomatös vs. nicht granulomatös)
erfolgen.
Neue Therapieansätze für Speicheldrüsenmalignome
Authors: Nachtsheim Lisa , Prinz Johanna , Arolt Christoph , Quaas Alexander , Meyer Moritz , Klußmann Jens Peter , Wolber Philipp 
Published: March 2022

ZusammenfassungIn den vergangenen Jahren haben sich durch die Verbesserung und Verbreitung molekularpathologischer Testverfahren und die Möglichkeit von zielgerichteten Therapien neue Optionen in der Behandlung von Speicheldrüsenmalignomen ergeben. Durch die neuen zielgerichteten Therapieoptionen werden Patienten deutlich weniger toxische Alternativen zur konventionellen zytostatischen Chemotherapie geboten. Zum einen gibt es neue entitätsspezifische Therapien, wie z.B. die Therapie mit NTRK-Inhibitoren bei sekretorischen Karzinomen und die Therapie mit Axitinib bei adenoidzystischen Karzinomen. Darüber hinaus rücken aber auch entitätsübergreifende Therapeutika, wie z.B. die antiandrogene Therapie, die HER2-Inhibition oder auch die PI3K-Inhibition, in den Vordergrund. Bei metastasierten/rezidivierten Speicheldrüsenkarzinomen, welche nicht mit einer zielgerichteten Therapie behandelt werden können, werden weiterhin hauptsächlich platinbasierte Chemotherapien eingesetzt.
Radical Oxyazidation of Alkenes in Pure Water
Authors: Zhou Huan , Li Yajun , Cui Jinfeng , Bao Hongli 
Published: March 2022

AbstractCompared to universal radical difunctionalizations of alkenes that are performed with organic solvents, such reactions with water as the sole solvent are rarely reported. Concerning the global consensus on environmental issues, we have developed herein a method for the radical oxyazidation of alkenes in pure water. This reaction allows the construction of C–N and C–O bonds in a one-pot process. Styrenes, 1,3-dienes, and unactivated alkenes react smoothly under mild and environmentally benign conditions to afford a wide scope of functionalized azides in excellent yields and selectivities.
Subacute Thyroiditis Following SARS-CoV-2 Vaccines: Six Cases Report
and Review of the Literature
Authors: Kurtulmus Neslihan , Kayikci Kubra 
Published: March 2022

AbstractSubacute thyroiditis (SAT) is an inflammatory disease of the thyroid that
develops following viral upper respiratory tract infections. SARS-CoV-2 virus,
the cause of COVID-19, binds to the Angiotensin-Converting Enzyme-2 (ACE2)
molecule expressed on the target cell surface. Thyroid gland shows high levels
of ACE2 expression. The cases of SARS-CoV-2-related subacute thyroiditis and
Graves’ disease have been reported. It has recently been noted that
vaccines for SARS-CoV-2 also induce autoimmune and inflammatory reactions. We
present six (4 male, 2 female) cases of SAT that developed after mRNA and
inactivated SARS-CoV-2 vaccines. And we have reviewed the literature. SAT was
seen in 5 patients after mRNA vaccine, in one after inactivated vaccine. Their
clinic and laboratory findings suggested to SAT. They were treated with
nonsteroid anti-inflamatory drugs and/or methylprednisolone.They
recovered within few weeks. Out patients did not have permanent hypothyroidism
after SAT. The history of SARS-CoV-2 vaccination should be questioned in
patients with subacute thyroiditis in pandemic days.
A single-shot vaccine approach for the universal influenza A vaccine candidate M2e
Authors: Kavishna Ranmali , Kang Tha Yang , Vacca Maurizio , Chua Benson Yen Leong , Park Hae-Young , Tan Peck Szee , Chow Vincent TK , Lahoud Mireille H , Alonso Sylvie 
Published: March 2022

Significance
Although the need for a universal influenza vaccine has long been recognized, only a handful of candidates have been identified so far, with even fewer advancing in the clinical pipeline. The 24–amino acid ectodomain of M2 protein (M2e) has been developed over the past two decades. However, M2e-based vaccine candidates have shortcomings, including the need for several administrations and the lack of sustained antibody titers over time. We report here a vaccine targeting strategy that has the potential to confer sustained and strong protection upon a single shot of a small amount of M2e antigen. The current COVID-19 pandemic has highlighted the importance of developing versatile, powerful platforms for the rapid deployment of vaccines against any incoming threat.
The virota and its transkingdom interactions in the healthy infant gut
Authors: Beller Leen , Deboutte Ward , Vieira-Silva Sara , Falony Gwen , Tito Raul Yhossef , Rymenans Leen , Yinda Claude Kwe , Vanmechelen Bert , Van Espen Lore , Jansen Daan , Shi Chenyan , Zeller Mark , Maes Piet , Faust Karoline , Van Ranst Marc , Raes Jeroen , Matthijnssens Jelle 
Published: March 2022

Significance
Microbes colonizing the infant gut during the first year(s) of life play an important role in immune system development. We show that after birth the (nearly) sterile gut is rapidly colonized by bacteria and their viruses (phages), which often show a strong cooccurrence. Most viruses infecting the infant do not cause clinical signs and their numbers strongly increase after day-care entrance. The infant diet is clearly reflected by identification of plant-infecting viruses, whereas fungi and parasites are not part of a stable gut microbiota. These temporal high-resolution baseline data about the gut colonization process will be valuable for further investigations of pathogenic viruses, dynamics between phages and their bacterial host, as well as studies investigating infants with a disturbed microbiota.
Likelihood-based non-Markovian models from molecular dynamics
Authors: Vroylandt Hadrien , Goudenège Ludovic , Monmarché Pierre , Pietrucci Fabio , Rotenberg Benjamin 
Published: March 2022

SignificanceThe analysis of complex systems with many degrees of freedom generally involves the definition of low-dimensional collective variables more amenable to physical understanding. Their dynamics can be modeled by generalized Langevin equations, whose coefficients have to be estimated from simulations of the initial high-dimensional system. These equations feature a memory kernel describing the mutual influence of the low-dimensional variables and their environment. We introduce and implement an approach where the generalized Langevin equation is designed to maximize the statistical likelihood of the observed data. This provides an efficient way to generate reduced models to study dynamical properties of complex processes such as chemical reactions in solution, conformational changes in biomolecules, or phase transitions in condensed matter systems.
KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3
Authors: Soh Heun , Springer Kristen , Doci Klarita , Balsbaugh Jeremy L. , Tzingounis Anastasios V. 
Published: March 2022

Significance
There are five KCNQ channels (KCNQ1–KCNQ5) and they are thought to either homomerize or heteromerize to form tetrameric channels. KCNQ2 and KCNQ3 are highly expressed in the brain and in particular the forebrain, the presumed site of action for many brain disorders. For the last 30 years, the prevailing view is that KCNQ potassium channels in the brain consist of KCNQ2/3 and possibly KCNQ3/5 heteromers. Here, using epitope-tagged knockin mice and split-intein–mediated protein trans-splicing experiments, we demonstrate that KCNQ2 channels form heteromers not only with KCNQ3 but also with KCNQ5 channels. Thus, our findings of unexpected KCNQ subunit composition will shift both our understanding of KCNQ genotype/phenotype relationships as well as drug screening strategies.
Context matters
Authors: Hänsel Eva Canan , Westphal Michael , Meer Philipp , Deuber Dagmar 
Published: March 2022

Abstract
This paper presents the results of two largely parallel verbal guise studies that elicited students’ attitudes
toward different standard varieties of English. The studies were conducted in the small anglophone Caribbean island country of
Grenada. The two studies were contextualized in the domains of education and newscasting, respectively, with the aim of finding
out how language attitudes are influenced by context in societies where different endo- and exonormative standards are of
relevance. As hypothesized, the results revealed strong differences between the evaluations of speakers of the two domains and
confirm that contextualization is crucial in language attitude research. Against previous hypotheses, however, the acceptance of
endonormative standard accents was stronger in the more globally open context of newscasting than in the more locally restricted
domain of education. The results are discussed against the background of the sociolinguistic situation in Grenada and inform on
endonormativity and norm orientation in one of the underresearched island countries of the anglophone Caribbean.
Zamboanga Chavacano
Authors: Melchor Jillian Loise , Blázquez-Carretero Miguel 
Published: March 2022

Abstract
Existing literature on Philippine languages is rife with references to Chavacano, the hypernym for Spanish-based
creoles spoken in various parts of the archipelago. Variants of Chavacano are characterised in historical accounts as ‘a corrupt
Spanish dialect’ with depreciative labels such as español de tienda ‘hawker Spanish’ or español de
cocina ‘kitchen Spanish’. The concerted assertion of this creole’s degeneracy is a legacy of colonial knowledge
production. Since the genesis of the Philippine creoles, much has changed as to their usage both from a linguistic and a social
viewpoint. It is in this social dimension that we locate the present study. Of the three main varieties of Chavacano, spoken in
Cavite City, Ternate, and Zamboanga respectively, this paper zeroes in on the third as the Mindanaoan variety is the healthiest to
date. We wish to interrogate the trajectory of its social status, from its characterisation as a degenerate variant of Spanish to
its privileged position in contemporary Zamboanga City as a Hispanic identity marker (Chavacano un poquito
español ‘Chavacano slightly Spanish’). Nuancing the role played in language preservation efforts by Zamboangueño
elites, this study highlights the singularity of a creolophone community, who, through the politicisation of heritage, has
subverted the ideological marginality of their Creole mother tongue and appropriated it to be the hallmark of their ethnic
identity.
Dauphin, sirène, coq basilic, vent marin
Authors: Colombo Timelli Maria 
Published: March 2022

Résumé
Le Dialogus creaturarum, recueil de 122 fables compilé au XIVe siècle par un auteur anonyme, a joui d’un succès européen, manuscrit et imprimé, qui s’est prolongé jusque vers 1550; trois versions françaises en sont connues: les deux premières en prose, l’une de Colard Mansion (1482), l’autre anonyme (1482 également), la plus tardive, manuscrite et en vers, de Jean Gontier (ca 1539–1549).
Les créatures de Dieu, protagonistes de ces récits, y interviennent selon l’ordre de la Genèse: la section consacrée aux poissons, la quatrième, comprenant les dialogues 37 à 48. L’intérêt du recueil ne réside pourtant pas dans ce qu’il nous dit sur les poissons (il ne fait que confirmer le caractère non homogène de la catégorie, qui indique au Moyen Âge un groupe malaisé à appréhender, piscis étant tout animal / être vivant qui vit dans l’eau), ni dans le contenu des enseignements impartis (conseils de prudence; mises en garde contre les femmes ou les vices: avarice, hypocrisie, superbe, colère, ingratitude; les fables sur les poissons ne se distinguant pas des autres), ni encore dans les descriptions fournies, mais justement dans la présence même de ces êtres dans un recueil de fables. L’analyse proposée ici prend en compte tant les aspects lexicographiques et textuels que l’iconographie, qui concourt, dans l’ensemble de la tradition, à l’approche et à la compréhension du recueil.
Audiometric notch as a sign of noise induced hearing loss (NIHL) among the rice and market flour mill workers in Tamil Nadu, South India
Authors: Narasimhan Sharanya , Rajagopalan Ramakrishnan , Justin Margret Jeffrey , Visvanathan Gnanaprakash , Jayasankaran Chandru , Rekha Kota , Srisailapathy C. R. Srikumari 
Published: March 2022

Objective
This study aims to determine the prevalence of NIHL among rice and flour mill workers exposed to high decibel noise levels at the workplace.

Methods
One-hundred and seven workers exposed to noise from rice and flour mill machinery and 82 age-matched controls not exposed to noise at the workplace were recruited for the study from the south Indian state of Tamil Nadu. All the mill workers and the controls were evaluated for their hearing thresholds by pure-tone audiometry.

Results
The characteristic bilateral notch in 4000 Hz was detected in 25% of the mill workers, while the prevalence of the unilateral or bilateral notch was observed in 51%. The high-frequency slope (HFS) involving HL at 4000 and 8000 Hz was observed in 23.36 and 29.92% among the left and right ears of the mill workers, respectively. Years of experience and exposure to noise were strongly associated with a bilateral notch in 4000 Hz (the odds of having the notch increased with increased years of noise exposure). Self-reported HL under-represented the rates of actual HL, indicating perception of the HL was absent till audiometric evaluation revealed the loss.

Conclusion
Our study demonstrates exposure to high noise levels in this unorganized sector of rice and flour mill workers. Awareness education of NIHL, early detection, and the use of personal hearing protection devices can prevent HL from extending to speech frequencies.
The full quadratic metric-affine gravity (including parity odd terms): exact solutions for the affine-connection
Authors: Iosifidis Damianos 
Published: March 2022

Abstract
We consider the most general quadratic metric-affine gravity setup in the presence of generic matter sources with non-vanishing hypermomentum. The gravitational action consists of all 17 quadratic invariants (both parity even and odd) in torsion and non-metricity as well as their mixings, along with the terms that are linear in the curvature namely the Ricci scalar and the totally antisymmetric Riemann piece. Adding also a matter sector to the latter we first obtain the field equations for the generalized quadratic theory. Then, using a recent theorem, we successfully find the exact form of the affine connection under some quite general non-degeneracy conditions. Having obtained the exact and unique solution of the affine connection we subsequently derive the closed forms of spacetime torsion and non-metricity and also recast the metric field equations into a GR form with modified source terms that are quadratic in the hypermomentum and linear in its derivatives. We also study the vacuum quadratic theory and prove that in this instance, or more generally for vanishing hypermomentum, the connection becomes the Levi-Civita one. Therefore, we also find exactly to what does the quadratic vacuum theory correspond to. Finally, we generalize our result even further and also discuss the physical consequences and applications of our study.
Permeability estimation of a porous structure in cancer treatment based on sampled velocity measurement*
Authors: Afshar Sepideh , Hu Weiwei 
Published: March 2022

Abstract
The problem of parameter identification appears in many physical applications. A parameter of particular interest in cancer treatment is permeability, which modulates the fluidic streamlines in the tumor microenvironment. Most of the existing permeability identification techniques are invasive and not feasible to identify the permeability with minimal interference with the porous structure in their working conditions. In this paper, a theoretical framework utilizing partial differential equation (PDE)-constrained optimization strategies is established to identify a spatially distributed permeability of a porous structure from its modulated external velocity field measured around the structure. In particular, the flow around and through the porous media are governed by the steady-state Navier–Stokes–Darcy model. The performance of our approach is validated via numerical and experimental tests for the permeability of a 3D printed porous surrogate in a micro-fluidic chip based on the sampled optical velocity measurement. Both numerical and experimental results show a high precision of the permeability estimation.
Germination and growth improvement of papaya utilizing oxygen (O2) plasma treatment
Authors: Ahmed Naeem , Shahid Muhammad , Siow Kim S , Razip Wee M F Mohd , Haron Farah Farhanah , Patra Anuttam , Fazry Shazrul 
Published: March 2022

Abstract
In general, cold plasma treatment improves crop germination and growth. The purpose of this research is to examine the impact of low-pressure O2 plasma treatment on the germination and growth kinetics of papaya seeds. Seeds were treated for 40 s at a discharge power of 80 W using O2 as a monomer. Physical and chemical changes were studied to understand the mechanism of germination and growth improvement. Furthermore, changes in phytohormones and antioxidant activity that were beneficial to germination were also examined. O2 plasma treatment improved wettability, surface etching, and oxidation, and affected other molecular-level changes leading to a 16% germination improvement in papaya.
Theoretical and experimental study on a new reconstruction model based on geometric optics for a single-lens biprism-based stereovision system
Authors: Wang Mu 
Published: March 2022

Abstract
In the present work, we report a stereovision system with one single camera. The configuration has only one single camera in front of which a biprism is placed. A new mathematical model based on optical geometrical optics is proposed for a single-lens biprism-based (SLBB) stereovision system in this paper. The path of each ray in three-dimensional (3D) space is tracked precisely, and the intersection of the rays is determined by an optimization method. Under the assumption of pinhole imaging, the 3D coordinate of the measuring point can be obtained through this model. Further, the model has been examined and verified by experiment. The experimental results show that the mathematical model can effectively measure the depth of the measuring points and the relative distance between measuring points. The deviation between the reconstruction results of the measuring point and the real 3D coordinate shows a certain regularity with the changing of the distance between the measuring point and the camera.