bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating global demand for land-based transportation services using the shared socioeconomic pathways scenario framework
Authors: Nkiriki Joan , Jaramillo Paulina , Williams Nathan , Davis Alex , Armanios Daniel Erian 
Published: July 2022

Abstract
The global demand for transportation is growing owing to accelerated socioeconomic development worldwide. If the current modes of transportation, consisting mostly of personal internal combustion engine vehicles, dominate this growth, greenhouse gas emissions will rise and worsen the climate crisis. A key empirical challenge in understanding the barriers and opportunities for low-carbon transportation systems in developing countries is the lack of demand data. Because existing country-specific transport demand models focus on countries with robust historical datasets, it has been difficult to estimate the service demand for developing countries. To address this limitation, we develop a log–log regression model linking socioeconomic variables with demand for land-based passenger and freight transport services. Using socioeconomic data from the shared socioeconomic pathways (SSPs) developed for climate analysis, we then produce scenario-based estimates for land-based transportation services for 179 countries around the world. The global average annual land-based passenger demand growth rate ranges between 1.3% and 4.1%, while the annual growth rate for land-based freight demand ranges between 3.1% and 3.6% across the 30 years between 2020 and 2050. Middle-income countries in Asia such as India and China, show the highest expected transport demand across all scenarios. Meanwhile, the results suggest that low-income countries in the sub-Saharan African region are likely to experience the largest growth in demand for passenger and freight transport services. These two trends come together at an inflection point around the year 2030. Prior to 2030, the transport demand was the highest in East Asia. After 2030, there is an ascendancy in transport demand in South Asia and sub-Saharan Africa, whereby the cumulative demand share of these two regions reaches near parity with that of East Asia by 2050. Sustainably meeting this growing demand will require the adoption of data-driven transport planning tools and leveraging cross-linkages across other energy sectors such as electricity.
Public Governance and Technological Capabilities in the Kenyan Leather Industry
Authors: Pasquali Giovanni , De Marchi Valentina 
Published: July 2022

ABSTRACT
This article focuses on small- and medium-sized enterprises (SMEs) in Kenya’s leather sector. It explores how public governance impacts SMEs’ technological capabilities and access to global value chains (GVCs). By public governance, we mean all government regulations and interventions set in place to shape the organization of value chains. Drawing on interview data, the article compares Kenya’s leather handbag and footwear manufacturers. On the one hand, handbag SMEs have succeeded in upgrading and entering GVCs through a combination of foreign knowledge and partnership with local universities. Despite meeting with public governance barriers, this process has enabled the transfer of technological capabilities from foreign-owned firms to a number of emerging SMEs owned by Kenyan nationals. On the other hand, leather footwear production was developed during the 1970s by large firms under state support. As protectionist measures were lifted in the 1990s, firms shut down and producers moved into the informal economy, replicating outdated capabilities in a context of price-driven competition, thereby limiting upgrading and participation in GVCs. The article concludes by comparing these findings with the experience of Kenya’s apparel manufacturers and highlighting the critical need for GVC research to account for the role of public governance in shaping firms’ technological capabilities and access to global markets.
Selective corticofugal modulation on sound processing in auditory thalamus of awake marmosets
Authors: Wang Xiaohui , Zhang Yuanqing , Zhu Lin , Bai Siyi , Li Rui , Sun Hao , Qi Runze , Cai Ruolan , Li Min , Jia Guoqiang , Cao Xinyuan , Schriver Kenneth E , Li Xinjian , Gao Lixia 
Published: July 2022

AbstractCortical feedback has long been considered crucial for the modulation of sensory perception and recognition. However, previous studies have shown varying modulatory effects of the primary auditory cortex (A1) on the auditory response of subcortical neurons, which complicate interpretations regarding the function of A1 in sound perception and recognition. This has been further complicated by studies conducted under different brain states. In the current study, we used cryo-inactivation in A1 to examine the role of corticothalamic feedback on medial geniculate body (MGB) neurons in awake marmosets. The primary effects of A1 inactivation were a frequency-specific decrease in the auditory response of most MGB neurons coupled with an increased spontaneous firing rate, which together resulted in a decrease in the signal-to-noise ratio. In addition, we report for the first time that A1 robustly modulated the long-lasting sustained response of MGB neurons, which changed the frequency tuning after A1 inactivation, e.g. some neurons are sharper with corticofugal feedback and some get broader. Taken together, our results demonstrate that corticothalamic modulation in awake marmosets serves to enhance sensory processing in a manner similar to center-surround models proposed in visual and somatosensory systems, a finding which supports common principles of corticothalamic processing across sensory systems.
Exorbitant privilege and compulsory duty: the two faces of the financialised IMS
Authors: Carneiro Ricardo , De Conti Bruno 
Published: July 2022

Abstract
Aiming at analysing the constraints to economic development, the article takes as reference the classic Economic Commission for Latin America and the Caribbean (ECLAC) approach to centre–periphery relations and seeks to update it from two points of view: adding the new historical context of the financialisation of capitalism and highlighting the new format and operation of the International Monetary System (IMS). The article’s objective is thus analysing the effects of financialisation on the IMS, emphasising the hierarchies of this system and its consequences for the economic dynamic of centre and peripheral countries. The main hypothesis is that financialisation has produced changes in cross-border capital flows, but also – and chiefly – in the ‘nature’ of the key-currency of the IMS. As a consequence, the exorbitant privilege of the reserve currency issuing country reaches a paroxysm, while peripheral countries are victims of a ‘compulsory duty’.
Spacemake: processing and analysis of large-scale spatial transcriptomics data
Authors: Sztanka-Toth Tamas Ryszard , Jens Marvin , Karaiskos Nikos , Rajewsky Nikolaus 
Published: July 2022

Abstract

Background
Spatial sequencing methods increasingly gain popularity within RNA biology studies. State-of-the-art techniques quantify messenger RNA expression levels from tissue sections and at the same time register information about the original locations of the molecules in the tissue. The resulting data sets are processed and analyzed by accompanying software that, however, is incompatible across inputs from different technologies.

Findings
Here, we present spacemake, a modular, robust, and scalable spatial transcriptomics pipeline built in Snakemake and Python. Spacemake is designed to handle all major spatial transcriptomics data sets and can be readily configured for other technologies. It can process and analyze several samples in parallel, even if they stem from different experimental methods. Spacemake's unified framework enables reproducible data processing from raw sequencing data to automatically generated downstream analysis reports. Spacemake is built with a modular design and offers additional functionality such as sample merging, saturation analysis, and analysis of long reads as separate modules. Moreover, spacemake employs novoSpaRc to integrate spatial and single-cell transcriptomics data, resulting in increased gene counts for the spatial data set. Spacemake is open source and extendable, and it can be seamlessly integrated with existing computational workflows.
Genome-wide SNPs reveal fine-scale genetic structure in ornate spiny lobster Panulirus ornatus throughout Indo-West Pacific Ocean
Authors: Farhadi Ahmad , Pichlmueller Florian , Yellapu Bhargavi , Lavery Shane , Jeffs Andrew 
Published: July 2022

Abstract
Genome-wide, single nucleotide polymorphism (SNP) typing can improve the management of valuable marine species by delineating finer scale population structure compared with traditional markers. This approach was applied to the spiny lobster, Panulirus ornatus distributed in the Indo-West Pacific and is one of the most highly valuable seafood products in the world. A total of 3008 SNPs was generated from DArTseq sequencing of 224 lobsters sampled at 13 locations across the Indo-Pacific. SNPs revealed a highly significant genetic structure among samples (analysis of molecular variance FST = 0.046). Pairwise genetic comparison showed significant differences among the majority of sampling locations. Outlier loci (including an outlier SNP mapped to the CASc gene with different allele frequencies among sampling locations) revealed highly significant pairwise differentiation, especially a genetic break between regional populations in northern Australia and South East Asia. Significant pairwise differences in outliers among sampling locations, even over small geographic scales, suggest a possible role of local adaptation on the population structure. Genetic differences identified among samples from northern Australia and South East Asia are sufficient to refute the single-stock hypothesis proposed using conventional genetic markers. The results of genome-level SNPs identify five management units across the species’ range, with significant implications for the future fisheries management and aquaculture development of this species.
Prevalence and factors associated with treatment and control of hypertension among adults with hypertension in Myanmar
Authors: Haung Ze , Hong Seo Ah 
Published: July 2022

AbstractBackgroundDue to a dearth in the number of studies conducted in low- and middle-income countries, this study aimed to identify the prevalence and determinants of the treatment and control of hypertension among patients with hypertension in Myanmar.MethodsThis community-based cross-sectional study was conducted among 410 adults who were registered for hypertensive treatment in health centers in Myitkyina Township, Kachin State, Myanmar. Multiple logistic regression was used to identify the associated factors.ResultsThe prevalence of treatment and control of hypertension was 48.1% and 20.5%, respectively. The factors associated with treatment were age (OR=2.60 for 46–60 y and OR=2.29 for 61–70 y compared with 30–45 y), ethnicity (OR=1.87), monthly family income (OR=1.90), comorbidity (OR=2.33), knowledge (OR=2.63) and adherence to physical activity (OR=1.86). Controlled hypertension was associated with age (OR=3.03 for 46–60 y and OR=2.27 for 61–70 y compared with 30–45 y), education (OR=1.81), comorbidity (OR=1.67) and adherence to medication (OR=3.45).ConclusionsThe prevalence of treated and controlled hypertension was relatively low in this study. To improve the prevalence of hypertension treatment and control in this study population, effective and culturally sensitive intervention programs under universal health coverage should be established with an emphasis on individuals with lower educational attainment and younger ages.
Talk from the Top: Leadership and Self-Legitimation in International Organizations
Authors: von Billerbeck Sarah 
Published: July 2022

AbstractHow do leaders create legitimacy in international organizations (IOs)? It is widely acknowledged that legitimacy matters to IOs, but little research examines internal self-legitimation—the creation of legitimacy for staff, rather than for external audiences—and who specifically undertakes these self-legitimation activities in IOs. This paper fills these gaps by examining the particular role of leaders in self-legitimation and I develop a theoretical framework that shows (1) how leaders have a unique role to play as legitimators due to their high social status within the IO and their access to discursive resources for legitimation, (2) how leaders create internal legitimacy through the introduction or reintroduction of narratives and the creation of self-referential language, and (3) how leader-led self-legitimation entails three potential risks. I illustrate these points with three case studies, one from the World Bank and two from the United Nations. I conclude by proposing a new research agenda for this underexplored area of IO and legitimacy scholarship.
Acute abdomen in a known case of sigmoid cancer and review of Laplace Law: a case report
Authors: AlImam Ali , AlKhateeb Omar 
Published: July 2022

Abstract
In this case, we discuss a case of young female patient was admitted with acute abdomen after a week since the diagnosis of a metastatic colon cancer. The case prompts the revision of Laplace Law, which can be grossly proven on the specimen shown below. The patient presented with a peculiar nontender distended acute abdomen, which further explains the pathophysiology of perforation and peritonitis. This case also produces evidence of colorectal cancer present in the younger population allowing more room for investigating other factors causing it.
Arabidopsis flowering integrator SOC1 transcriptionally regulates autophagy in response to long-term carbon starvation
Authors: Li Xibao , Liao Jun , Bai Haiyan , Bei Jieying , Li Kailin , Luo Ming , Shen Wenjin , Yang Chao , Gao Caiji 
Published: July 2022

Abstract
Autophagy is a highly conserved, self-digestion process that is essential for plant adaptations to various environmental stresses. Although the core components of autophagy in plants have been well established, the molecular basis for its transcriptional regulation remains to be fully characterized. In this study, we demonstrate that SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1), a MADS-box family transcription factor that determines flowering transition in Arabidopsis, functions as a transcriptional repressor of autophagy. EMSAs, ChIP-qPCR assays, and dual-luciferase receptor assays showed that SOC1 can bind to the promoters of ATG4b, ATG7, and ATG18c via the conserved CArG box. qRT-PCR analysis showed that the three ATG genes ATG4b, ATG7, and ATG18c were up-regulated in the soc1-2 mutant. In line with this, the mutant also displayed enhanced autophagy activity, as revealed by increased autophagosome formation and elevated autophagic flux compared with the wild type. More importantly, SOC1 negatively affected the tolerance of plants to long-term carbon starvation, and this process requires a functional autophagy pathway. Finally, we found that SOC1 was repressed upon carbon starvation at both the transcriptional and protein levels. Overall, our study not only uncovers an important transcriptional mechanism that contributes to the regulation of plant autophagy in response to nutrient starvation, but also highlights novel cellular functions of the flowering integrator SOC1.
A Promiscuity Locus Confers Lotus burttii Nodulation with Rhizobia from Five Different Genera
Authors: Zarrabian Mohammad , Montiel Jesús , Sandal Niels , Ferguson Shaun , Jin Haojie , Lin Yen-Yu , Klingl Verena , Marín Macarena , James Euan K. , Parniske Martin , Stougaard Jens , Andersen Stig U. 
Published: July 2022

Legumes acquire access to atmospheric nitrogen through nitrogen fixation by rhizobia in root nodules. Rhizobia are soil-dwelling bacteria and there is a tremendous diversity of rhizobial species in different habitats. From the legume perspective, host range is a compromise between the ability to colonize new habitats, in which the preferred symbiotic partner may be absent, and guarding against infection by suboptimal nitrogen fixers. Here, we investigate natural variation in rhizobial host range across Lotus species. We find that Lotus burttii is considerably more promiscuous than Lotus japonicus, represented by the Gifu accession, in its interactions with rhizobia. This promiscuity allows Lotus burttii to form nodules with Mesorhizobium, Rhizobium, Sinorhizobium, Bradyrhizobium, and Allorhizobium species that represent five distinct genera. Using recombinant inbred lines, we have mapped the Gifu/ burttii promiscuity quantitative trait loci (QTL) to the same genetic locus regardless of rhizobial genus, suggesting a general genetic mechanism for symbiont-range expansion. The Gifu/ burttii QTL now provides an opportunity for genetic and mechanistic understanding of promiscuous legume-rhizobia interactions. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Evaluation of the AmplifyRP XRT+ Kit for the Detection of Xylella fastidiosa by Recombinase Polymerase Amplification
Authors: Cesbron Sophie , Dupas Enora , Jacques Marie-Agnès 
Published: July 2022

Xylella fastidiosa is a quarantine priority pest in Europe and several other countries as it represents a major threat to many cultivated and wild plants. Early detection of the pathogen is needed to reduce potential losses and to stop the bacterial dissemination. Very few molecular methods are available for rapid field detection to identify the pathogen. Here, we evaluated a new rapid commercial detection test called AmplifyRP, based on molecular recombinase polymerase amplification (RPA). The AmplifyRP test was compared with the quantitative PCR (qPCR) Harper's assay, which represents the standard method used in most laboratories all over the world. Specificity was tested in vitro on a panel of target and nontarget strains. Additionally, the sensitivity of the RPA test was tested on X. fastidiosa genomic DNA, and the selectivity was compared between different host plant matrices spiked with X. fastidiosa cell suspensions. Although the qPCR assay showed a higher sensitivity than the RPA test, the latter appeared to be a very specific, rapid, and portable technique for which no skills are required to proceed. These findings should enable growers and inspectors to choose an appropriate diagnostic method. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Nursing Faculty Resilience During a Time of Disruption and Change
Authors: Hampton Debra , Hardin-Fanning Fran , Hensley Angie , Culp-Roche Amanda , Wilson Jessica L. , Thaxton-Wiggins Amanda 
Published: July 2022

Abstract
Assessing the resilience level of nursing faculty during a time of unprecedented change in nursing education was the focus of this study. A descriptive cross-sectional survey that incorporated demographic data and the 10-item Connor-Davidson Resilience Scale was used. Participants (n = 78) had an average resilience score of 32.6. No correlation was found between resilience and demographic variables such as age, years of teaching experience, and type of nursing program. Resilience is important because it helps faculty assimilate various protective factors and persist during times of rapid change.
Management of adverse reactions induced by chemotherapy drugs
Authors: Abreu Daniela Brandão , Cernadas Josefina Rodrigues 
Published: July 2022

Purpose of review
There is a broad spectrum of chemotherapy-induced adverse reactions. Hypersensitivity reactions are being extensively studied as they can affect the ideal treatment. The goal of this review is to describe the current management of adverse reactions to chemotherapy, focusing on hypersensitivity events.

Recent findings
The range of possible desensitization protocols is increasing, as well as the delabeling algorithms and diagnostic tools. One-bag desensitization protocols, omalizumab use in immediate hypersensitivity reactions, slow desensitization protocols in nonimmediate hypersensitivity reactions and standardization of skin tests for platinum drugs, are some examples.

Summary
The handling of adverse reactions to chemotherapy is evolving, with the increasing identification of hypersensitivity reactions and the development of strategies for their management, to maintain the culprit drug.
Ohio Abortion Regulations and Ethical Dilemmas for Obstetrician–Gynecologists
Authors: Field Meredith P. , Gyuras Hillary , Bessett Danielle , Pensak Meredith J. , Norris Alison H. , McGowan Michelle L. 
Published: July 2022

OBJECTIVE:
To analyze obstetrician–gynecologists' (ob-gyns’) experiences with, and perspectives on, how Ohio's abortion-restrictive regulatory landscape affects their health care practices.

METHODS:
Between 2019 and 2020, we conducted qualitative interviews and focus groups with ob-gyns (N=35) who had practiced in Ohio for at least 6 months between 2010 and 2020. Discussions were recorded, transcribed, coded, and analyzed thematically using ATLAS.ti software.

RESULTS:
Participants perceived Ohio abortion regulations affecting their practice in three key ways: abortion regulations framed abortion and physicians who provide abortion as separate and distinct from other medical practices and physicians; many institutional interpretations of abortion regulations undermined physician expertise and professional autonomy; and the constellation of abortion regulations, institutional interpretations, physicians' trepidation, and their perceived inability to exercise clinical judgment worked together to limit abortion access and increase risks to patients' lives and health. The combined factors left participants feeling distraught that they were unable to practice medicine in an ethical and compassionate manner.

CONCLUSION:
Ohio abortion regulations limit ob-gyns' ability to provide comprehensive reproductive health care, creating ethical dilemmas for these physicians as they attempt to care for their patients. As Ohio's abortion laws increase in number and restrictiveness, they further undermine obstetric and gynecologic ethical practice guidelines. However, medical institutions play a key role in determining abortion provision in Ohio; through their interpretation of the law, institutions can demonstrate support or further limit ob-gyns’ ability to exercise clinical judgment and provide ethical, compassionate care to their patients. Considerable work remains to bring Ohio's abortion regulations, institutional interpretations, and physician practices into alignment with professional clinical practice and ethics guidelines.