bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevance of circulating Semaphorin 4A for rheumatoid arthritis progression and response to treatment
Authors: Avouac Jérôme , Vandebeuque Eloïse , Combier Alice , Poiroux Lucile , Steelandt Alexia , Boisson Margaux , Gonzalez Virginie , Cauvet Anne , Barnetche Thomas , Truchetet Marie-Elise , Richez Christophe , Allanore Yannick 
Published: June 2022

Abstract
Background: The lack of validated tools to predict rheumatoid arthritis (RA) disease course warrants the development of new reliable biomarkers. We have previously detected increased semaphorin 4A (SEMA4A) expression in endothelial cells, synovial tissue, and serum of patients with RA. In addition, SEMA4A serum levels correlated with multiple clinical, biological, and power doppler ultrasound markers of disease activity. Our aim was to evaluate circulating SEMA4A for the prediction of outcomes in patients with RA.Methods: A first cohort included between May 2016 and February 2018 101 consecutive RA patients followed up on an annual basis until August 2021. Baseline SEMA4A concentrations were analyzed according to disease progression defined for the purpose of this study by the occurrence of patient-reported flares and initiation or change of targeted therapy. A second cohort included 40 consecutive RA patients who initiated new therapy because of insufficient disease control. The course of SEMA4A levels was studied between baseline and month 3 according to treatment response. Results: During a follow-up period of 41±15 months, disease progression occurred in 26/101 patients in the first cohort. Increased baseline SEMA4A levels were identified as an independent predictor of disease progression (hazard ratio, HR: 2.71, 95%CI 1.14-6.43). The highest predictive value of disease progression was obtained with the combination of increased circulating SEMA4A and/or DAS28-CRP>3.2 and/or synovial hyperemia on doppler ultrasound (HR: 10.42, 95%CI 1.41-76.94). SEMA4A was also predictive of disease progression in patients with a DAS28 <3.2 at baseline.In the second cohort, baseline SEMA4A levels were significantly higher in patients who further experienced none or moderate response, and SEMA4A concentrations were markedly decreased in the group of patients with good clinical response as compared to non-responders.Conclusion: circulating SEMA4A appears as an appealing biomarker in RA with ability to predict disease progression, and with association with response to therapy.
Heat Flux Reduction of Satellites and Spacecraft
Authors: LE Trang , SUZUKI Yasuhiro , HASEGAWA Hiroki , MORITAKA Toseo , OHTANI Hiroaki 
Published: June 2022

Abstract
The reduction of high electron and ion heat fluxes is one of the critical issues for shielding satellite and spacecraft. One of the ideas for shielding high particle and heat fluxes is to apply an external magnetic field generated by injecting current filaments. In this work, we model a flow of plasma, which includes electrons and ions in a small region, by using two spatial dimensions and three coordinates for velocities (2D3V) Particle-In-Cell (PIC) code, to study the effects of the injected current filaments on particle and heat fluxes to the wall. The plasma enters the simulation domain from the source region at the left boundary and is fully absorbed at the conductor wall at the right boundary. Current filaments are injected to change the magnetic field structure of the system. We compare particle density, particle flux and heat flux with and without injecting the current filaments into the domain in two dimensions. Based on the simulation results, we found that injecting current filaments can reduce the peak fluxes to the wall and transfer some of those fluxes along the wall. Therefore, injecting the current filaments is a good candidate for shielding high energy ion and electron fluxes to the satellites or spacecraft.
Oropharyngeal Swallowing Physiology and Safety in Patients with Idiopathic Pulmonary Fibrosis: A consecutive descriptive case series
Authors: Alamer Mrs Amal , Jones Rhys , Drinnan Michael , Simpson Prof. A. John , Griffin Prof. Mike , Patterson Prof. Joanne M , Althuwaybi Abdullah , Ward Prof. Chris , Forrest Ian 
Published: June 2022

Abstract
Introduction: Dysphagia occurs in multiple respiratory pathophysiologies, increasing the risk of pulmonary complications secondary to aspiration. Reflux associated aspiration and a dysregulated lung microbiome is implicated in Idiopathic Pulmonary Fibrosis (IPF), but swallowing dysfunction has not been described. We aimed to explore oropharyngeal swallowing in IPF patients, without known swallowing dysfunction. Methods: Fourteen consecutive outpatients with a secure diagnosis of IPF were recruited and the 10-item Eating Assessment Tool (Eat 10) used to assess patient perception of swallowing difficulty. Oropharyngeal swallowing was assessed in ten patients using Videofluoroscopy Swallow Studies (VFSS). The studies were rated using validated scales: Penetration-Aspiration Scale (PAS); standardised Modified Barium Swallow Impairment Profile (MBSImP). Results: EAT-10 scores indicated frank swallowing difficulty in 4/14 patients. Videofluoroscopy Studies showed that 3/10 patients had airway penetration, and one aspirated liquid without a cough response. Median MBSImp for oral impairment was 5, range [3-7] and pharyngeal impairment 4, range [1-14] indicating, overall mild alteration to swallowing physiology. Conclusion: We conclude that people with IPF can show a range of swallowing dysfunction, including aspiration into an unprotected airway. To our knowledge, this is the first report on swallowing physiology and safety in IPF. We believe a proportion of this group may be at risk of aspiration. Further work is indicated to fully explore swallowing in this vulnerable group.
The Effects of Informal Competition on Manufacturing Firm Productivity in Ethiopia
Authors: Endale Kefyalew 
Published: June 2022

Abstract
This study investigates the relationships of informal competition with formal manufacturing firms labor productivity measured by value added per total fulltime workers and capacity utilization rates in Ethiopia. A combination of cross-sectional and panel regression methods are employed to investigate the relationships using the 2011 and 2015 World Bank Enterprise Surveys. The results from both the cross-sectional and panel analyses show that informal competition is significantly associated with lower labor productivity and capacity utilization rate. The negative effects of informal competition are large especially on large manufacturing firms which is a disincentive to firm growth. An additional finding is that those formal firms competing against the unregistered firms are found to engage in innovation practices especially in the methods of production and marketing to mitigate the negative consquences of informal competittors on their market performance. The policy implication of the findings is that Competition and Consumers’ Protection Authority (incollaboration with police and judciary) should exert more efforts to reduce the malpractices of informal competitors especially those engaging in brand piracy. Formalizing the informal competitors through improved access to credit, tax incentive, and training can also play an indispensable role. Firms should also promote their producs aggressively through different methods to help their customers identify genuine products from fakes.
Laparoscopic sleeve gastrectomy in Adolescence, Retrospective case-controlled study
Authors: Abdelgawad Mohamed , Sorogy Mohamed El , Fouad Amgad , Elrefei Mohamed , Hamed Hosam , El-Magd El-Sayed Abou , Makia Amr , Abdelrafee Ahmed 
Published: June 2022

Abstract
Purpose: Adolescent obesity is striking global health issue in the recent decades. Although non-surgical weight loss strategies have been crucial in obesity management in that age group, they have disappointing results. Consequently, growing interest has emerged on the surface in bariatric surgery for adolescents. Laparoscopic sleeve gastrectomy (LSG) can be an effective treatment option for adolescent obesity and controlling or even eliminating its obesity-related co-morbidities. Methods: Data was collected from the prospectively maintained database between 2014 to 2019 in Gastrointestinal surgical center, Mansoura University. Obese adolescents aged 12-19 years, who underwent LSG with a BMI of more than 40 kg/m2 or a BMI of greater than 35kg/m2 associated with obesity-related comorbidities were included. Results: Forty patients were included in the study: 18 male and 22 female. The median age was 17 years. The mean preoperative body weight and BMI were 147.15 ± 36.31 kg and 52.55 ± 11.61 kg/m2 respectively. Osteoarthritis and depression were the most common comorbidities in the study cohort (14 patients, 35%). After 2 years follow up, the EBWL was 40.84 kg. All patients had achieved %EBWL <50% at 12 months. No nutritional deficiency was encountered in the study period. All obesity related co-morbidities (DM, HTN, OSAS and dyslipidemia) have been resolved. Conclusion: Obese adolescent will grow into obese adult, with increasing burden on health care systems. LSG is feasible, effective, and safe for management of adolescent obesity in the terms of weight loss, resolution of obesity related comorbidities. Long-term follow up is needed in future studies.
Comprehensive analysis of Cuproptosis regulators in ccRCC and prospects for immunotherapy
Authors: Xue Zhaoyuan , Liu Jingkun , Nuerrula Yiliyaer , Tiliwalidi Aidiye , Yizihaer Subinuer , Aimudula Ainiwaer , Eli Mayinur 
Published: June 2022

Abstract
Based on data from the Cancer Genome Atlas (TCGA) on renal clear cell carcinoma(ccRCC), we noted different expression profiles of Cuproptosis regulators in ccRCC and normal tissues, and we also found that Cuproptosis regulators were associated with PD-L1 expression.Based on the expression levels of Cuproptosis regulators in ccRCC, two independent isoforms were identified by consensus clustering analysis. Cluster 1 showed lower histological tumor stage and grade, more favorable prognosis, and higher PD-L1 expression compared to cluster 2.CIBERSORT analysis revealed that cluster 2 contained higher levels of T cell CD8+,T cell regulatory (Tregs), NK cell activated and T cell follicular helper, whereas cluster 1 was more relevant to Monocytes, Macrophage M1, Macrophage M2, T cell and Mast cell activated.After analysis, we identified DLAT as a potential key regulator of Cuproptosis associated with immune infiltration, and its low expression showed a poor prognosis and positively correlated with PD-L1 expression in ccRCC.In addition, we performed a pan-cancer analysis of this gene, and DLAT expression was strongly correlated with the expression of immune checkpoint-related genes, particularly PD-L1, with unfavorable prognosis in multiple cancer types.In conclusion, this study reveals the potential role of Cuproptosis regulators in ccRCC and identifies biomarkers associated with Cuproptosis for prognosis and immunotherapy prediction.
Postoperative EGFR-TKI treatment on residual multiple ground-glass nodules after resection for lung adenocarcinoma:a case report and literature review
Authors: Dong Haijun , Zhang Jianbin , Min Weiwei , Shen Qibin 
Published: June 2022

Abstract
Background: Multiple ground-glass nodules (mGGNs) in the lung has been defined as synchronous multiple primary lung cancer (SMPLC), it is very difficult to differentiate SMPLC from intrapulmonary metastases, and the treatment is still controversial. Case presentation: We report a case of mGGNs simultaneously with lung adenocarcinoma harboring primary EGFR-T790M mutation, in which the patient underwent radical resection of lesions in the left upper lung, and continued osimertinib treatment for the residual mGGNs in all lobes of the right lung. The mGGNs in the right lung displayed different responses to osimertinib. Conclusions: We report a successful strategy on the postoperative treatment for mGGNs. For mGGNs that cannot be completely resected, chemotherapy, radiotherapy, stereotactic body radiation therapy (SBRT) ,immunotherapy and targeted therapy have been tried. EGFR-TKI therapy strategy shows obvious advantages, but how to achieve better therapeutic effect that needs more researches.
Inertial Scheme for Solving Two-Level Variational Inequality and Fixed Point Problem Involving Pseudomonotone and ϱ — Demimetric Mappings
Authors: Godwin Emeka C. , Mewomo Oluwatosin T. , Araka Nnamdi N. , Okeke Godwin A. , Ezeamama Grace C. 
Published: June 2022

Abstract
This work approximates the solution of two-level variational inequality and fixed point problem in a real Hilbert space where the underlying operators are pseudo-monotone and ϱ-demimetric. An iterative algorithm was developed and shown to converge strongly to the solution set of two-level variational inequality and fixed point problem. Four numerical examples are presented to further demonstrate the usefulness and applicability of our method. The result obtained extends, generalizes and compliments several existing results in this direction of research.
Contamination of drug-resistant Acinetobacter baumannii and its antibiotic resistance genes in the dust on the return vent filters of air-conditioners in hospital wards
Authors: Yuan Fengyun , Qiu Wanyue , Xia Yuhe , Gong Lin , Chen Qi , Li Jiahao , Liang Jiansheng , Tang Fei 
Published: June 2022

Abstract
Background
Acinetobacter baumannii (A. baumannii) has been one of the predominant causative agents of nosocomial infections. The purpose of this research was to study the situation of drug-resistant A. baumannii contamination in the dust on the return vent filters of air-conditioners in health care settings.
Methods
The study was conducted in 34 wards of three tertiary hospitals in Wuhan from November 2018 to November 2021. The dust samples on the return vent filters of air-conditioners were collected and inoculated on chromogenic media. A. baumannii were identified by time of flight mass spectrometry. Susceptibility testings were performed on the isolates using the Kirby-Bauer disk diffusion technique. Ten β-lactam antibiotic resistance genes (ARGs) was detected by PCR and quantitative PCR.
Results
A total of 279 strains producing β-lactamases and carbapenems were screened from 218 dust samples. A. baumannii was detected in 16.97% (37/218) of dust samples. The positive rate of dust samples in different wards were as follows: intensive care unites (ICUs) 20.97% (13/62), surgical wards 20.51% (16/78) and internal medicine wards 10.26% (8/78). Of the 49 A. baumannii colonies isolated, 12 were multidrug-resistance A. baumannii (MDRAB) with the highest proportion in ICUs. The frequency of blaADC, blaOXA−51, blaOXA−23 and blaKPC, blaVIM, blaTEM, blaCTX−M, blaSHV in A. baumannii were 100.00% (49/49), 79.59% (39/49), 59.18% (29/49), 59.18% (29/49), 46.94% (23/49), 44.90% (22/49), 32.65% (16/49) and 14.29% (7/49), respectively. However, blaIMP and blaNDM−1 were not detected. The relative quantitative value of ARGs from high to low were blaADC > blaOXA−51 > blaKPC > blaTEM > blaOXA−23 > blaCTX−M > blaVIM > blaSHV.
Conclusion
Drug-resistant A. baumannii was commom in the dust on the return vent filters of air-conditioners in hospital wards, especially in ICUs. ARGs of blaADC, blaOXA−51, and blaKPC genes were most in need of attention. The relative quantitative value of blaOXA−23 and blaTEM had a positive correlation with the drug resistance of A. baumannii.
Perceived Stress, Internet Use behaviors and Mental Health Symptoms During the Early Stages of the Pandemic in Brazil
Authors: Bergmann Carolina Goldman , Rahat Maryam , Mojgani Juliette , Sideris Beth , Dwyer Heather , Patterson Beth , Ameringen Michael Van 
Published: June 2022

Abstract
Purpose: This study explores perceived stress (PS), mental health (MH) symptoms and internet use behaviors during early stages of the pandemic in Brazil. Methods: A questionnaire battery was posted on various internet platforms from April to July 2020. The questionnaires included various life domains, internet use behaviors, MH symptoms, PS and quality of life, Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, Perceived Stress Scale, Obsessive Compulsive Inventory – Revised, PTSD Checklist and Quality of Life Enjoyment and Satisfaction Questionnaire. Results: Majority of participants (n=519) reported changes to financial status (71%) and social communication (89%) and various internet use behaviors (79-89%). This sample reported elevated PS (x̄=17.09, SD=8.37, 62%), mild depression (x̄=6.44, SD=5.98) and anxiety (x̄=6.62, SD=5.37) and a significant proportion had clinically significant symptoms of MDD (25%), GAD (23%), OCD (14%), PTSD (18%) and elevated PS (62%). Elevated PS was predicted by younger age (β=-0.063, p=0.005), female sex (β=0.581. p=0.05), loss of employment (β=0.665, p=0.05), healthcare worker status (β=-0.589, p=0.005), past mental health treatment (β =0.739, p=0.005) increased social media use (β=0.591, p=0.05) and increased digital information seeking (β=0.697, p=0.05). Conclusion: Mental health providers should assess internet use habits and behaviors as a potential risk factor for heightened stress.
Prediction of prednisolone dose correction using machine learning
Authors: Sato Hiroyasu , Kimura Yoshinobu , Ohba Masahiro , Ara Yoshiaki , Wakabayashi Susumu , Watanabe Hiroaki 
Published: June 2022

Abstract
PurposeWrong dose, a common prescription error, can cause serious patient harm, especially in the case of high-risk drugs like oral corticosteroids. This study aims to build a machine learning model to predict dose-related prescription modifications for oral prednisolone tablets (ie, highly imbalanced data with very few positive cases). MethodPrescription data were obtained from the electronic medical records at a single institute. Cluster analysis classified the clinical departments into six clusters with similar patterns of prednisolone prescription. Two patterns of training datasets were created with/without preprocessing by the SMOTE method. Five ML models (SVM, KNN, GB, RF, and BRF) and Logistic Regression (LR) models were constructed by Python. The model was internally validated by five-fold stratified cross validation and was validated with a 30% holdout test dataset. Result82,553 prescribing data for prednisolone tablets containing 135 dose-corrected positive cases were obtained. In the original dataset, only the BRF model showed a good performance (in test dataset, ROC-AUC:0.917, Recall: 0.951). In the training dataset preprocessed by SMOTE, performance was improved on all models. The highest performance models with SMOTE were SVM (in test dataset, ROC-AUC:0.820, Recall: 0.659) and BRF (ROC-AUC:0.814, Recall: 0.634).ConclusionAlthough the prescribing data for dose-related collection are highly imbalanced, various techniques such as the following have allowed us to build high-performance prediction models: data preprocessing by SMOTE, stratified cross-validation, and BRF classifier corresponding to imbalanced data. ML is useful in complicated dose audits such as oral prednisolone.
Hypochlorous Acid Inactivates Oral Pathogens And A SARS-CoV- 2-surrogate
Authors: Tazawa Kento , Jadhav Rutuja , Azuma Mariane Maffei , Fenno J. Christopher , McDonald Neville J. , Sasaki Hajime 
Published: June 2022

Abstract
Background
Droplets and aerosols produced during dental procedures are a risk factor for microbial and viral transmission. Unlike sodium hypochlorite, hypochlorous acid (HOCl) is nontoxic to tissues but still exhibits broad microbicidal effect. HOCl solution may be applicable as a supplement to water and/or mouthwash in dental practice. This study aims to evaluate the effectiveness of HOCl solution on common human oral pathogens and a SARS-CoV-2 surrogate MHV-A59 virus, considering the dental practice environment.
Methods
HOCl was generated by electrolysis of 3% hydrochloric acid. The effect of HOCl on human oral pathogens, Fusobacterium nucleatum, Prevotella intermedia, Streptocuccus intermedius, Parvimonas micra, and MHV-A59 virus was studied from four perspectives: concentration; volume; presence of saliva; and storage. HOCl solution in different conditions was utilized in bactericidal and virucidal assays, and the minimum inhibitory volume ratio that is required to completely inhibit the pathogens was determined.
Results
In the absence of saliva, the minimum inhibitory volume ratio of freshly prepared HOCl solution (45–60 ppm) was 4:1 for bacterial suspensions and 6:1 for viral suspensions. The presence of saliva increased the minimum inhibitory volume ratio to 8:1 and 7:1 for bacteria and virus, respectively. Applying a higher concentration of HOCl solution (220 or 330 ppm) did not lead to a significant decrease in the minimum inhibitory volume ratio against S. intermedius and P. micra. The minimum inhibitory volume ratio increases in applications of HOCl solution via the dental unit water line. One week of storage of HOCl solution degraded HOCl and increased the minimum growth inhibition volume ratio.
Conclusions
HOCl solution (45–60 ppm) is still effective against oral pathogens and a SARS-CoV-2 surrogate virus even in the presence of saliva and after passing through the dental unit water line. This study indicates that the HOCl solution can be used as therapeutic water or mouthwash and may ultimately reduce the risk of the airborne infection in dental practice.
Determinants of non-primary, primary, and exclusive use of liquefied petroleum gas vary significantly in a nationally representative survey in Ghana
Authors: Kar Abhishek , Tawiah Theresa , Graham Linnea , Owusu-Amankwah Georgette , Daouda Misbath , Malagutti Flavio , Chillrud Steve , Iddrisu Seidu , Apraku Edward , Tetteh Richard , Jack Kelsey , Abubakari Sulemana , Jack Darby , Asante Kwaku Poku 
Published: June 2022

Abstract
Clean cooking transitions can have profound public health, environmental and societal gains for 2.6 billion people in the Global South. We use data from the largest household energy survey (n= 7,389) in Ghana to provide novel insights. One, regression analysis with thirteen commonly cited socio-economic and demographic predictors indicates that these factors have remarkably different levels of influence at different stages of the transition process. We propose a stage-based intervention strategy and customer targeting approach that could be a paradigm shift in how clean cooking interventions are rolled out. Two, we identify factors that are associated with exclusive use of LPG using a statistically powered sample of exclusive LPG users (n= 693). We find that everything else being equal, increases in wealth, and residing in an urban location are not associated with a transition from primary to exclusive LPG use.