bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co‐detection of Copper and Lead in Artisanal Sugarcane Spirit Using Caffeic Acid‐modified Graphite Electrodes
Authors: Soares Priscila I. , Lima Thaís M. , do Nascimento Luiza. A. , Coelho Rafael M. , Franco Diego L. , Pereira Arnaldo C. , Ferreira Lucas F. 
Published: November 2022

AbstractCaffeic acid (CA)‐modified graphite electrodes [GE/poly(CA)] was applied to the co‐detection of copper and lead in artisanal sugarcane spirit using square‐wave anodic stripping voltammetry (SWASV). Electrochemical and morphological studies were performed, and a mechanism for polymerization was proposed. Electropolymerization, SWASV, and analysis conditions parameters were optimized. Interferents, repeatability, reproducibility, and addition and recovery tests were carried out. GE/poly(CA) shows a linear range from 15 to 705 μg/L with a limit of detection of 3.01 μg/L for Pb(II) and 4.50 μg/L for Cu(II). Real samples of artisanal sugarcane spirit were used, and the electrochemical results were compared with atomic absorption spectroscopy experiments.
Scaled shaking table testing of higher‐mode effects on the seismic response of tall and slender structures
Authors: Zhong Chiyun , Christopoulos Constantin 
Published: November 2022

AbstractAs structures are built taller and more slender, their response becomes increasingly sensitive to dynamic loads that are induced by the buildings’ higher‐frequency vibration modes. This leads to a more complex seismic response of high‐rise structures when compared to the seismic response of low‐rise structures that are primarily governed by their fundamental modes of vibration. This paper presents the results of extensive shake table testing and finite element analyses of a small‐scale, 1.5‐meter‐tall shaking table specimen that was designed and scaled to experimentally capture the higher‐mode effects of a 125‐meter‐tall reference tall building. The test specimen is comprised of a simplified superstructure with uniform mass and stiffness representing the main structure of the full‐scale reference tall building, and a base‐rocking mechanism to represent the moment‐limiting effect of the inelastic plastic‐hinging mechanism at the base of the reference building. Using the methodology proposed in this paper, the scaled specimen was shown to exhibit similar seismic response characteristics, including the corresponding higher‐mode effects, along the height of the structure as those predicted numerically on the full‐scale reference building. Results of the shaking table tests experimentally provided further evidence that relying only on a moment‐limiting mechanism at the base of a cantilever structure is insufficient in limiting peak seismic loads due to higher‐mode effects. In addition, by comparing test results with predictions obtained using several previously proposed analytical methods, the paper demonstrated that predicting shear force amplifications due to higher‐mode effects is still challenging. The methodology developed in this study can be used to design other similar small‐scale shaking table tests for the development of new analytical methods to predict higher mode effects and experimentally validate the efficiency of new high‐performance systems developed to mitigate higher‐mode effects on tall and slender structures and more generally to assess the ability of these systems to achieve enhanced seismic resilience.
A hydraulic modelling approach to study flood sediment deposition in floodplain lakes
Authors: Reinders Joeri B. , Sullivan Richard M. , Winkler Tyler S. , van Hengstum Peter J. , Beighley R. Edward , Munoz Samuel E. 
Published: November 2022

AbstractAbandoned river channels on alluvial floodplains represent areas where sediments, organic matter, and pollutants preferentially accumulate during overbank flooding. Theoretical models describing sedimentation in floodplain lakes recognize the different stages in their evolution, where the threshold for hydrological connectivity increases in older lakes as a plug‐bar develops. Sedimentary archives collected from floodplain lakes are widely used to reconstruct ecological and hydrological dynamics in riverine settings, but how floodplain lake evolution influences flow velocities and sedimentation patterns on an event scale remains poorly understood. Here we combine sediment samples collected in and around a floodplain lake with hydraulic modelling simulations to examine inundation, flow velocity, and sedimentation patterns in a floodplain lake along the Trinity River at Liberty, Texas. We focus our analyses on an extreme flood event associated with the landfall of Hurricane Harvey in August 2017 and develop a series of alternative lake bathymetries to examine the influence of floodplain lake evolution on flow velocity patterns during the flood. We find that sediments deposited in the lake after the Hurricane Harvey flood become thinner and finer with distance from the tie‐channel in accordance with simulated flow velocities that drop with distance from the tie‐channel. Flow velocity simulations from model runs with alternative plug‐bar geometries and lake depths imply that sedimentation patterns will shift as the lake evolves and infills. The integration of sediment sampling and hydraulic model simulations provides a method to understand the processes that govern sedimentation in floodplain lakes during flood events that will improve interpretations of individual events in sedimentary archives from these contexts.
Social difficulties in adolescent attention deficit hyperactivity disorder: Social motivation, social anxiety and symptom severity as contributing factors
Authors: McKay Erin , Kirk Hannah , Martin Rachael , Cornish Kim 
Published: November 2022

AbstractBackgroundMany interventions have been developed to address the social difficulties commonly experienced by adolescents with attention‐deficit/hyperactivity disorder (ADHD), yet they are largely ineffective.ObjectiveThis study examined social impairment among adolescents with and without ADHD, determining whether gender, social anxiety, age, and ADHD symptom type (inattention and hyperactivity/impulsivity) and severity are associated with social impairment.MethodParents and primary caregivers of adolescents (aged 13–17) with (n = 76) and without ADHD (n = 36) completed the Strengths and Weaknesses of ADHD and Normal Behavior, Social Responsiveness Scale 2nd Edition, and Spence Children's Anxiety Scale.ResultsAdolescents with ADHD scored significantly higher than TD adolescents across social impairment domains. ADHD symptoms were associated with severity of impairment in all domains excluding Social Motivation. Hyperactivity/impulsivity and social anxiety predicted social impairment, whereas gender did not.ConclusionAdolescents with ADHD are more likely to experience social impairment than TD adolescents, and interventions targeting symptom reduction and social anxiety may improve these social impairments.
Successful heart transplantation in an infant with phosphoglucomutase 1 deficiency (PGM1‐CDG)
Authors: Altassan Ruqaiah , Albert‐Brotons Dimpna C. , Alowain Mohammad , Al‐Halees Zohair , Jaeken Jaak , Morava Eva 
Published: November 2022

AbstractWe report successful heart transplantation in a phosphoglucomutase 1 deficient (PGM1‐CDG) patient. She presented with facial dysmorphism, bifid uvula and structural heart defects. Newborn screening was positive for classic galactosemia. The patient was on a galactose‐free diet for 8 months. Eventually, whole exome sequencing excluded the galactosemia and revealed PGM1‐CDG. Oral D‐galactose therapy was started. Rapid deterioration of the progressive dilated cardiomyopathy prompted heart transplantation at the age of 12 months. Cardiac function was stable in the first 18 months of follow‐up, and hematologic, hepatic, and endocrine laboratory findings improved during D‐galactose therapy. The latter therapy improves several systemic symptoms and biochemical abnormalities in PGM1‐CDG but does not correct the heart failure related to cardiomyopathy. Heart transplantation has so far only been described in DOLK‐CDG.
On the importance of color in mass spectrometry imaging
Authors: Knizner Kevan T. , Kibbe Russell R. , Garrard Kenneth P. , Nuñez Jamie R. , Anderton Christopher R. , Muddiman David C. 
Published: November 2022

AbstractMass spectrometry imaging (MSI) data visualization relies on heatmaps to show the spatial distribution and measured abundances of molecules within a sample. Nonuniform color gradients such as jet are still commonly used to visualize MSI data, increasing the probability of data misinterpretation and false conclusions. Also, the use of nonuniform color gradients and the combination of hues used in common colormaps make it challenging for people with color vision deficiencies (CVDs) to visualize and accurately interpret data. Here we present best practices for choosing a colormap to accurately display MSI data, improve readability, and accommodate all CVDs. We also provide other resources on the misuse of color in the scientific field and resources on scientifically derived colormaps presented herein.
Clinical features, therapeutic outcomes, and recovery period of long COVID
Authors: Takakura Kazuki , Suka Machi , Kajihara Mikio , Koido Shigeo 
Published: November 2022

AbstractTo characterize the clinical features of long COVID, 286 patients who received care in our outpatient clinic for long COVID from May to December 2021 were surveyed. The recovery periods of each symptom and the key factors contributing to early recovery were statistically analysed. The median age of the patients was 35.8 years, with 137 men and 149 women. The median number of symptoms was 2.8. The most frequent symptoms were respiratory manifestations (52.1%), followed by fatigue (51.4%). Respiratory symptoms, fatigue, and headache/arthralgia were major complaints in the initial phase, whereas hair loss was a major complaint in the late phase, suggesting that the chief complaint of patients with long COVID may vary temporally. The best treatment outcome was observed for pulmonary symptoms, and hair loss had the worst outcome. COVID‐19 severity, the number of manifestations, and the delay in starting treatment exerted a negative effect on the recovery period of long COVID. In addition, the smoking habit was an independent risk factor for slowing the recovery period from long COVID. This study provides insights into the clinical course of each manifestation and therapeutic options with a more certain future of long COVID to meet the unmet medical needs.
Vascular perfusion differs in two distinct PDGFRβ‐positive zones within the ischemic core of male mice 2 weeks following photothrombotic stroke
Authors: Morris Gary P. , Gowing Emma K. , Courtney Jo‐Maree , Coombe Hannah E. , King Natalie E. , Rewell Sarah S. J. , Howells David W. , Clarkson Andrew N. , Sutherland Brad A. 
Published: November 2022

AbstractStroke therapy has largely focused on preventing damage and encouraging repair outside the ischemic core, as the core is considered irreparable. Recently, several studies have suggested endogenous responses within the core are important for limiting the spread of damage and enhancing recovery, but the role of blood flow and capillary pericytes in this process is unknown. Using the Rose Bengal photothrombotic model of stroke, we illustrate blood vessels are present in the ischemic core and peri‐lesional regions 2 weeks post stroke in male mice. A FITC‐albumin gel cast of the vasculature revealed perfusion of these vessels, suggesting cerebral blood flow (CBF) may be partially present, without vascular leakage. The length of these vessels is significantly reduced compared to uninjured regions, but the average width is greater, suggesting they are either larger vessels that survived the initial injury, smaller vessels that have expanded in size (i.e., arteriogenesis), or that neovascularization begins with larger vessels. Concurrently, we observed an increase in platelet‐derived growth factor receptor beta (PDGFRβ, a marker of pericytes) expression within the ischemic core in two distinct patterns, one which resembles pericyte‐derived fibrotic scarring at the edge of the core, and one which is vessel associated and may represent blood vessel recovery. We find little evidence for dividing cells on these intralesional blood vessels 2 weeks post stroke. Our study provides evidence flow is present in PDGFRβ‐positive vessels in the ischemic core 2 weeks post stroke. We hypothesize intralesional CBF is important for limiting injury and for encouraging endogenous repair following cerebral ischemia.
Dermatologists' perspectives on healthcare of patients with atopic dermatitis: A cross‐sectional study in Germany
Authors: Tizek Linda , Tizek Lucas , Schneider Simon , Wecker Hannah , Biedermann Tilo , Zink Alexander 
Published: November 2022

AbstractBackgroundAtopic dermatitis (AD) is a common chronic skin disease causing substantial individual and overall socioeconomic burden.ObjectivesThe aim of this study was to gain information on the healthcare of patients with AD from dermatologists' perspectives.MethodsFor this cross‐sectional study, office‐based dermatologists in Southern Germany were contacted by mail in June 2021, who received a questionnaire that assessed, for example, individual data, annual number of patients, treatment satisfaction, and awareness of patients' online searches.ResultsThe 98 participating dermatologists (mean age 53.2 ± 10.3 years, 53.1% male) reported treating a median of 300 patients with AD yearly, of those 11.0% had a severe form. Two‐thirds of physicians were consulted at least six times a year by severely affected patients. Many physicians were contacted by several patients who were pretreated by other physicians. Topical corticosteroids were the most frequently used therapy. The median proportion of patients receiving a biological was 2.0%. While nearly all dermatologists (89.8%) were satisfied with the effectiveness of available therapies, only 37.7% were satisfied with their costs. Concerning perceived treatment satisfaction among patients, 65.3% of patients with severe AD seemed satisfied. Patient use of the internet for health information was indicated to be beneficial for the awareness of AD by 74.5% of physicians, whereas most found it obstructive to patients' claims (69.1%) and therapy decisions (48.4%). Nearly the same proportion mentioned that online searches were an obstacle for (37.9%) or had no effect on (38.9%) the physician–patient relationship.ConclusionsThe results indicated that care of AD, especially in severely affected people, can still be improved. Additionally, from the dermatologists' perspectives, online searches mostly have a negative effect on several healthcare‐related aspects.
Accounting for spatial heterogeneity in visual obstruction in line‐transect distance sampling of gopher tortoises
Authors: Gaya Heather E. , Smith Lora L. , Moore Clinton T. 
Published: November 2022

AbstractLine‐transect distance sampling (LTDS) surveys are commonly used to estimate abundance of animals or objects. In terrestrial LTDS surveys of gopher tortoise (Gopherus polyphemus) burrows, the presence of ground‐level vegetation substantially decreases detection of burrows of all sizes, but no field or analytical methods exist to control for spatially heterogeneous vegetation obstruction as a source of variation in detection. We propose the addition of a simple measurement of ground‐level vegetation that serves as a covariate for the detection function. We present a Bayesian hierarchical model in which covariates burrow width and nearby vegetation height help to account for detection bias and improve precision of estimated density. We investigate the performance of this covariate by simulation and by using real LTDS data collected before and after application of prescribed fire. We collected data in 2018 at the Jones Center at Ichauway in Newton, Georgia, USA. Across all simulations, our model including both covariates produced the most accurate density point estimates of any of the models tested. For our case study, our Bayesian model with vegetation covariates tended to produce similar estimates of density before and after burns. Our study indicates that any level of spatial variation in vegetation obstruction decreases detection of burrows and may lead to underestimation in population size (≤68%) and proportion of individuals with small burrow sizes (≤32%) when not considered during analysis. Our work is extensible to other terrestrial sampling efforts where systematic measurement of a spatially distributed obstructing feature is feasible during the LTDS survey.
Is it risky to subscribe? Perceived control and subscription choice
Authors: Roy Arani , Ortiz Maria 
Published: November 2022

AbstractSubscription commerce is an integral part of today's consumption space. Researchers have identified different factors that influence subscription intent and different mechanisms that are used to evaluate subscription options. In this research, we investigate the effect of loss of perceived control on subscription intent and explore a new underlying mechanism used for the evaluation of subscription options. Across six studies in the field and laboratory, we show that when consumers lose their level of perceived control, they are likely to exhibit higher subscription intent for monthly subscription options than yearly subscription options, and we explain the mechanism through risk aversion. Particularly, we find that individuals experiencing loss of control are more likely to evaluate subscription options based on associated risk, and subsequently choose the option that appears less risky. Our findings contribute to the literature by identifying a novel risk‐based mechanism driving subscription choice and by finding a new consumer‐related antecedent of subscription choice in perceived control.
An endoluminal cylindrical sectored‐ring ultrasound phased‐array applicator for minimally‐invasive therapeutic ultrasound
Authors: Zubair Muhammad , Adams Matthew S. , Diederich Chris J. 
Published: November 2022

AbstractBackgroundThe size of catheter‐based ultrasound devices for delivering ultrasound energy to deep‐seated tumors is constrained by the access pathway which limits their therapeutic capabilities.PurposeTo devise and investigate a deployable applicator suitable for minimally‐invasive delivery of therapeutic ultrasound, consisting of a 2D cylindrical sectored‐ring ultrasound phased array, integrated within an expandable paraboloid‐shaped balloon‐based reflector. The balloon can be collapsed for compact delivery and expanded close to the target position to mimic a larger‐diameter concentric‐ring sector‐vortex array for enhanced dynamic control of focal depth and volume.MethodsAcoustic and biothermal simulations were employed in 3D generalized homogeneous and patient‐specific heterogeneous models, for three‐phased array transducers with 32, 64, and 128 elements, composed of sectored 4, 8, and 16 tubular ring transducers, respectively. The applicator performance was characterized as a function of array configuration, focal depth, phasing modes, and balloon reflector geometry. A 16‐element proof‐of‐concept phased array applicator assembly, consisting of four tubular transducers each divided into four sectors, was fabricated, and characterized with hydrophone measurements along and across the axis, and ablations in ex vivo tissue.ResultsSimulation results indicated that transducer arrays (1.5 MHz, 9 mm OD × 20 mm long), balloon sizes (41–50 mm expanded diameter, 20–60 mm focal depth), phasing mode (0–4) and sonication duration (30 s) can produce spatially localized acoustic intensity focal patterns (focal length: 3–22 mm, focal width: 0.7–8.7 mm) and ablative thermal lesions (width: 2.7–16 mm, length: 6–46 mm) in pancreatic tissue across a 10–90 mm focal depth range. Patient‐specific studies indicated that 0.1, 0.46, and 1.2 cm3 volume of tumor can be ablated in the body of the pancreas for 120 s sonications using a single axial focus (Mode 0), or four, and eight simultaneous foci in a toroidal pattern (Mode 2 and 4, respectively). Hydrophone measurements demonstrated good agreement with simulation. Experiments in which chicken meat was thermally ablated indicated that volumetric ablation can be produced using single or multiple foci.ConclusionsThe results of this study demonstrated the feasibility of a novel compact ultrasound applicator design capable of focusing, deep penetration, electronic steering, and volumetric thermal ablation. The proposed applicator can be used for compact endoluminal or laparoscopic delivery of localized ultrasound energy to deep‐seated targets.
Natural source compatibilizers for olive waste/recycled polypropylene matrix composites
Authors: Rapoport Zohar , Levy Galy , Dotan Ana 
Published: November 2022

AbstractA simple, environmentally friendly process was developed for surface hydrophobization of cellulose‐rich waste to improve their compatibility with recycled polypropylene (rPP), helping reduce costs while recycling environmentally problematic waste such as solid olive waste (also called olive pomace). In this study, an improvement of the interfacial bonding strength between the hydrophilic waste particles and the hydrophobic matrix was achieved by surface hydrophobization of the waste using a ring‐opening polymerization reaction of epoxidized soy‐bean oil (ESBO) with SnCl2 as a catalyst. The treatment on cellulose based filter paper led to a contact angle of 128°. The composite containing treated olive pomace has shown an increase in the elongation of 92% and an increase in the stress at yield of 15%, indicating improved compatibility.
In vitro characterization of the intramelanosomal domain of human recombinant TYRP1 and its oculocutaneous albinism type 3‐related mutant variants
Authors: Dolinska Monika B. , Anderson David E. , Sergeev Yuri V. 
Published: November 2022

AbstractTyrosinase related protein 1 (TYRP1) is the most abundant melanosomal protein of the melanocyte, where plays an important role in the synthesis of eumelanin, possibly catalyzing the oxidation of 5,6‐dihydroxyindole‐2‐carboxylic acid to 5,6‐quinone‐2‐carboxylic acid. Mutations to the TYRP1 gene can result in oculocutaneous albinism type 3 (OCA3), a rare disease characterized by reduced synthesis of melanin in skin, hair, and eyes. To investigate the effect of genetic mutations on the TYRP1 structure, function, and stability, we engineered the intramelanosomal domain of TYRP1 and its mutant variants mimicking either OCA3‐related changes, C30R, H215Y, D308N, and R326H or R87G mutant variant, analogous to OCA1‐related pathogenic effect in tyrosinase. Proteins were produced in Trichoplusia Ni larvae, then purified, and analyzed by biochemical methods. Data shows that D308N and R326H mutants keep the native conformations and demonstrate no change in their stability and enzymatic activity. In contrast, mutations C30R and R87G localized in the Cys‐rich domain show the variants misfolding during the purification process. The H215Y variant disrupts the binding of Zn2+ in the active site and thus reduces the strength of the enzyme/substrate interactions. Our results, consistent with the clinical and in silico studies, show that mutations at the protein surface are expected to have a negligible phenotype change compared to that of TYRP1. For the mutations with severe phenotype changes, which were localized in the Cys‐rich domain or the active site, we confirmed a complete or partial protein misfolding as the possible mechanism of protein malfunction caused by OCA3 inherited mutations.