bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of simplicity, convenience, safety, and cost-effectiveness between use of insulin pen devices and disposable plastic syringes by patients with type 2 diabetes mellitus: a cross-sectional study from Bangladesh
Authors: Kamrul-Hasan A.B.M. , Hannan Mohammad Abdul , Alam Muhammad Shah , Rahman Mohammad Motiur , Asaduzzaman Md. , Mustari Marufa , Paul Ajit Kumar , Kabir Md. Lutful , Chowdhury Sumon Rahman , Talukder Samir Kumar , Sarkar Sourav , Hannan Muhammad Abdul , Islam Md. Rashedul , Iftekhar Mohammad Hasan , Robel Md. Abdul Bari , Selim Shahjada 
Published: September 2022

Abstract
Introduction:
Many patients with type 2 diabetes mellitus (T2DM) need insulin to achieve glycemic control in the long run. Insulin pen devices and disposable plastic insulin syringes are two common tools for insulin administration. Data comparing these two common insulin delivery devices are scarce in this area. This study aims to compare the simplicity, convenience, safety, and cost-effectiveness of using insulin pens versus syringe devices in patients with T2DM.
Methods
A cross-sectional study was conducted at several diabetes outpatient clinics throughout Bangladesh from November 2021 to April 2022 among adults with T2DM injecting insulin by pen devices or disposable insulin syringes at least once a day for at least one year. A structured questionnaire in Bangla was used to assess the simplicity, convenience, safety, and cost-effectiveness of insulin devices, and the study subjects were scored based on their answers. The highest obtainable scores for simplicity, convenience, and safety were 15, 9, and 15, respectively; higher scores indicated a poorer response.
Results
A total of 737 subjects were evaluated in this study; 406 were pen users, and 331 were vial syringe users. The pen users had lower median scores for simplicity [6.0 (5.0–8.0) vs. 7.0 (5.0–9.0), p = 0.002], convenience [4.0 (3.0–6.0) vs. 5.0 (4.0–6.0), p < 0.001], and safety [7.0 (6.0–8.0) vs. 7.0 (6.0–9.0), p = 0.008] than vial syringe users. Pen devices were more expensive than vial syringes in terms of average medical expense per month [BDT 5000 (3500–7000) vs. 3000 (2000–5000), p < 0.001], the total cost of insulin therapy per month [BDT 2000 (1500–3000) vs. 1200 (800–1700), p < 0.001] and cost per unit of insulin used [BDT 2.08 (1.39–2.78) vs. 0.96 (0.64–1.39), p < 0.001]. Non-significant differences in favor of pens were observed in HbA1c levels [8.7 (7.8–10) vs. 8.9 (7.9–10)%, p = 0.607] and proportions of subjects having HbA1c < 7% (6.9 vs. 6.3%, p = 0.991).
Conclusions
Insulin pens are simpler, more convenient, and safe to use but expensive than vial syringes. Glycemic control is comparable between pen and syringe users. Long-term follow-up studies are needed to determine the clinical and economic impacts of such benefits of insulin pens in our settings.
Arbitrary entanglement of three qubits via linear optics
Authors: Blasiak Pawel , Borsuk Ewa , Markiewicz Marcin 
Published: September 2022

Abstract
We present a linear-optical scheme for generating an arbitrary state of three qubits. It requires only three independent particles in the input and post-selection of the coincidence-type at the output. The success probability of the protocol is equal for any desired state. Furthermore, the optical design remains insensitive to particle statistics (bosons, fermions or anyons). This approach builds upon the no-touching paradigm, which demonstrates the utility of particle indistinguishability as a resource of entanglement for practical applications.
Lactate administration induces skeletal muscle synthesis by influencing Akt/mTOR and MuRF1 in non-trained mice but not in trained mice
Authors: Kyun Sunghwan , Kim Jisu , Hwang Deunsol , Jang Inkwon , Park Hun-Young , Lim Kiwon 
Published: September 2022

Abstract
Background: The perception regarding lactate has changed over the past decades, with some of its physiological roles having been revealed. However, the effects of exogenous lactate on skeletal muscle synthesis remain unclear. Therefore, this study aimed to confirm the effects of long-term and post-exercise lactate administration on skeletal muscle synthesis. Methods: 32 ICR mice were randomly assigned to non-trained + placebo (Non/Pla), non-trained + lactate (Non/Lac), tranied + placebo (Tr/Pla), or trained + lactate (Tr/Lac) groups. Lactate (3 g/kg) or same volume of saline was immediately administered after exercise training (70% VO2max). Lactate administration and/or exercise training was performed 5 days/week for 5 weeks. Results: After the experimental period, lactate administration tended to increase skeletal muscle weight and significantly enhanced the gastrocnemius muscle weight. Furthermore, lactate administration increased the mRNA levels of Akt (p = 0.000) and mTOR (p = 0.009), decreased protein expression of MuRF1 (p = 0.001), and reduced blood IGF1 levels (p = 0.039). However, lactate administration after exercise training had no additional effects on almost factors. Conclusions: These results suggest that long-term lactate administration have a potential to stimulate skeletal muscle synthesis, but lactate administration after exercise training may not be extra beneficial for increasing skeletal muscle because of the lactate administration timing.
Investigation of the characteristics of multileaf collimator position errors: dose distribution- based error classification
Authors: Sheen Heesoon , Shin Han-Back , Kim Hojae , Kim Changhwan , Kim Jihun , Kim Jin Sung , Hong Chae-Seon 
Published: September 2022

Abstract
Background The characteristics of the multileaf collimator (MLC) position error were investigated without clinical variability and other factors affecting the error analysis. An index indicating the attributes of MLC position error was found and used for MLC position error prediction model. The dose-volume histogram (DVH) was examined to investigate the clinical relationship.Methods: The dose distribution was investigated using the gamma index, structural similarity (SSIM) index, and dosiomics index. The cases from the American Association of Physicists in Medicine Task Group 119 were planned, and systematic and random MLC position errors were simulated. All error-free and error datasets were generated in the treatment plan system. The indices were obtained from distribution maps, and then statistically significant indices were selected. An MLC position error prediction model was developed using the selected indices and logistic regression method. The final model was determined when all values of the area under the curve (AUC), accuracy, precision, sensitivity, and specificity were higher than 0.8 (p<0.05). DVH relative percentage difference between the error-free and error datasets was examined to investigate clinical relations.Results: Statistically common significant indices were found, GLCM_Energy in Class-I and Class-III and GLRLM_LRHGE in Class-II. The final model was developed using indices that satisfied the statistical criteria. The number of finalized univariate predictive models was five in Class-I and Class-II and four in Class-III. Seven multivariate predictive models were finalized. The DVH relative percentage difference between the error-free and error dataset almost linearly increased as systematic error increased. In the case of random errors, the tendency of the DVH relative percentage difference was dependent on the structure’s location.Conclusion: Our study highlights three novel vital results. First, the common significant dosiomics indices (GLCM Energy and GLRLM_LRHGE) can characterize the MLC position error. Second, the finalized logistic regression model for MLC position error prediction showed excellent performance with AUC > 0.9. Third, the results of DVH were related to dosiomics analysis in that it reflects the characteristics of the MLC position error, and it was shown that dosiomics analysis could provide important information on localized dose distribution differences in addition to DVH information.
Profile of cardiovascular risk factors among child sexual abuse victims in Puerto Rico
Authors: Laras Linda Perez - , Laras Linda , Marzan-Rodríguez Melissa 
Published: September 2022

Abstract
Background

Exposure to childhood sexual abuse has a long-term impact on cardiovascular health. Cardiovascular disease is one of the leading causes of death among Hispanics. This study aimed to determine the prevalence of cardiovascular risk factors in a group of child sexual abuse victims in Puerto Rico. It also intended to identify the possible impact that the offender's relationship with the victim and the number of victimizations may have on said risk factors.

Methods

The study consisted of a retrospective chart review at a victim-centered clinical forensic service in Puerto Rico. Medical records were used to identify cardiovascular risk factors and variables associated with child sexual abuse victimization. Means, standard deviation (SD), and frequencies were used to describe the risk factors and the victimization. The Mann–Whitney and Fisher’s exact tests were used to determine the differences between the type of victimization and the risk factors for cardiovascular health.

Results

Most of the victims were female (81%), with an average age of 10 (SD 3.8) years. According to the 31 reviewed charts, 55% of the children had been sexually assaulted, the offender was a family member (84%), and the assault had occurred more than once (81%). Systolic blood pressure, diastolic blood pressure, total cholesterol, and body mass index (BMI) was found to be at unhealthy levels (based on age and sex); when the victim reported having been sexually assaulted, the offender was a family member, and more than one assault occurred. Systolic blood pressure, diastolic blood pressure, and fasting blood sugar were statistically significant among victims who reported being sexually assaulted and/or sexually molested when the offender was a family member, and the victimization occurred more than once.

Conclusion

This data shows that healthcare professionals who conduct interventions with victims of sexual abuse need to know the circumstances of their victimization to be responsive to their needs and prevent chronic health problems. The victims of child sexual abuse should be screened for cardiovascular risk factors.
Trial Registration: Not applicable.
Influence of allergic diseases on executive function development and ADHD symptoms: a longitudinal study in Korea
Authors: Shin Min-Gwan , Jeong Ji-Woon , Kim Ji-Hoon 
Published: September 2022

Abstract
Executive function (EF) encompasses a variety of cognitive domains that are deeply related to attention-deficit hyperactivity disorder (ADHD), which has a wide range of negative effects on life. The purpose of this study was to examine the influence of allergic diseases on EF development, and the relationship between EF and ADHD. This study used data from the 8th-11th Panel Study on Korean Children in 2015-2018. The data were based on an annual follow-up survey of 1,156 children from the age of 7 to 10. The EF was composed of 3 sub-areas in this study: planning-organization, behavior control, and emotional control. History of allergic diseases was investigated in the 8th wave and included asthma, allergic rhinitis (AR), and allergic dermatitis (AD). Attention-deficit hyperactivity (ADH) problem was measured based on the Child Behavior Checklist/6-18. Children with a history of asthma or AR generally showed more EF difficulties, but there were differences according to the diseases and sub-areas of EF. Asthma and AR also increased the correlation between EF difficulties and the ADH problem scale. In addition, the development of emotional control showed a different trajectory according to a history of asthma. We suggested that the relationship between allergic diseases and EF could be explained by structural changes in EF with age. In addition, allergic diseases may have a stronger association with inattention symptoms of ADHD, rather than hyperactive-impulsivity symptoms. The problem of EF difficulties associated with allergic diseases may be the key to understanding the relationship between allergic diseases and ADHD.
Beta and gamma binaural beats enhance auditory sentence comprehension
Authors: Kim Hyun-Woong , Happe Jenna , Lee Yune Sang 
Published: September 2022

Abstract
Binaural beats — an auditory illusion produced when two pure tones of slightly different frequencies are dichotically presented — have been shown to modulate various cognitive and psychological states. Here, we investigated the effects of binaural beat stimulation on auditory sentence processing that required interpretation of syntactic relations (Experiment 1) or an analysis of syntactic well-formedness (Experiment 2) with a large cohort of healthy young adults (N = 200). In both experiments, participants performed a language task after listening to one of four sounds (i.e., between-subject design): theta (7 Hz), beta (18 Hz), and gamma (40 Hz) binaural beats embedded in music, or the music-only. In Experiment 1, 100 participants indicated the gender of a noun linked to a transitive action verb in spoken sentences containing either a subject- or object-relative center-embedded clause. We found that both beta and gamma binaural beats yielded better performance, compared to music-only, especially for syntactically more complex object-relative sentences. To explore if the binaural beat effect can be generalized to another type of language task, we conducted Experiment 2 in which another 100 participants indicated whether or not there was a grammatical error in spoken sentences embedded with a subject- or object-relative clause. However, none of the binaural beats yielded better performance for this task indicating that the benefit of beta and gamma binaural beats may be specific to the interpretation of syntactic relations. Together, we demonstrate, for the first time, the positive impact of binaural beats on auditory language comprehension. Both theoretical and practical implications are discussed.
Evaluation of Peripheral Anterior Synechia Formation Following Gonioscopy Assisted Transluminal Trabeculotomy Surgery
Authors: Gunay Murat , Turk Adem , Ozturk Hilal , Bulanik Fatma Tugba , Uzlu Dilek 
Published: September 2022

Abstract
Purpose: To quantitatively assess the development of peripheral anterior synechia (PAS) formation rate and PAS locations on gonioscopic examination following gonioscopy-assisted transluminal trabeculotomy (GATT) surgery and investigate the surgical outcomes.Methods: A total of 35 eyes from 31 patients with open angle glaucoma who underwent GATT or combined GATT and phacoemulsification surgery as an initial glaucoma procedure were analyzed. Presence of PAS was assessed on gonioscopy in nasal, temporal, superior and inferior quadrants at months 1, 3 and 6 following surgery. Surgical outcomes were also noted.Results: The mean age of the patients was 68.8±9.2 years. The mean IOP and mean number of antiglaucoma medications decreased from 31.5±7.2 mmHg and 3.6±0.6 at baseline to 13.8±3.1 mmHg and 1.6±1.3 at postoperative 6 months, respectively (p<0.001, for both). Overall surgical success rate was found as 95.6% which was 30.4% without antiglaucoma medication. Mild to moderate degrees of hyphema occurred in all cases postoperatively. PAS formation rates were observed to be higher in nasal quadrant compared to temporal, superior and inferior quadrants on gonioscopy at months 1 (38.3%), 3 (34.0%) and 6 (32.3%) postoperatively. The highest amount of PAS involvement was 3 clock hours in the study which was identified only in nasal and inferior quadrants.Conclusion: PAS frequency was higher in nasal angle following GATT surgery. Broader PAS involvement was seen in both nasal and inferior angle regions.
Chemical composition of subcortical tissues of Quercus suber, the diet of the flathead oak borer Coraebus undatus (Coleoptera, Buprestidae)
Authors: Muñoz-Adalia Emigdio Jordán , Haque Mohammed Masum Ul , Gemeno César 
Published: September 2022

Abstract
Quercus suber is severely affected by the larva of the pest beetle Coraebus undatus, which develops and forms galleries in phellogen (cork cambium) and surrounding tissues corresponding to new phellem or cork (in the outer bark) and phelloderm plus the outer phloem (inner inner bark). To better understand the nutritional requirements of C. undatus we describe twelve chemical parameters (water content, fiber, six carbohydrates, total proteins, organic matter, and lignin) of these tissues. Phelloderm plus phloem contained higher amounts of cellulose, organic matter, and sucrose than phellem, and this contained higher quantities of fiber, fructose, lignin, and moisture than phelloderm plus phloem. Samples from infected trees were richer in glucose and hemicellulose, and poorer in fiber, lignin, water, and myo-inositol than those of uninfected trees.
Quality of Life and Disease Coping Strategies in Patients with Rosacea
Authors: Azrumelashvili Sopiko , Kituashvili Tina 
Published: September 2022

Abstract
Introduction: Rosacea is a chronic, inflammatory skin disorder that adversely affects patients' quality of life. The aim of the study was to evaluate the quality of life (QoL) and to find the connection between QoL and coping strategies in patients with rosacea. Design and methods: A total of 138 patients, aged from 22 to 80, took part in this study with the first-time confirmed diagnosis of rosacea. All patients completed the Dermatology Life Quality Index (DLQI) questionnaire to evaluate the patients’ attitudes to the impact of rosacea on QoL and Coping Strategies Questionnaires (COPE). Results: The study has determined that Average DLQI in the case of rosacea equals 14.09+3.18. Mean Rosacea-Specific DLQI is: symptoms and feelings - 3.75+1.92, daily activities - 3.12+1.77; leisure - 2.52+1.81, work and/or school - 1.52+1.50, personal relationships - 2.42+1.90, treatment - 1.59+1.04. The usage of instrumental social support - 3.39 has the highest score factor in the COPE questionnaire. Conclusions: Rosacea has a strong impact on human life. QoL in rosacea patients is connected to age, gender, employment status, self-esteem and subtype of the disease. Correlation analysis shows connection between the quality of life and coping strategy. Based on the regression analysis formula, the large and extremely large effect of DLQI can be calculated according to the existing risk forecast. The results obtained in our study may be a starting point for the elaboration of complex support for patients with rosacea.
The Transdiagnostic Oncology Program (TOP), a combined lifestyle intervention for improving the quality of life of cancer survivors: a controlled before-and-after pilot study in the primary care setting
Authors: Booij Sanne H. , Pieper Amy , Wester Christianne D. , Bültmann Ute , Waarsenburg Elkana C. , Hoenders H. J. Rogier 
Published: September 2022

Abstract
Purpose
There is a need for interdisciplinary primary care-led aftercare programs for the common (transdiagnostic) problems cancer survivors experience to increase their quality of life. The aim of this controlled before-and-after pilot study was to examine the feasibility and effectiveness of a transdiagnostic, family doctor-led interdisciplinary program to increase quality of life in a heterogeneous group of cancer survivors.
Methods
The intervention group (N = 19) followed a 12-month interdisciplinary aftercare program in the primary care setting, consisting of: family doctor consultation, physical exercise, mind-body therapy, sleep hygiene, dietary recommendations, and optional psychological therapy. Eligible cancer survivors who declined participation, were included as controls (N = 16). The primary outcome was quality of life, as measured with the EORTC-QOL-C30, covering global health status, and various forms of functioning and symptoms. Secondary outcomes included assessments of fatigue, mental health, happiness, and work ability. Assessments took place at baseline (T0), and 6 months (T1) and 12 months post-baseline (T2). Intention-to-treat multilevel analyses were conducted.
Results
At baseline, the intervention group scored significantly worse on several indices of quality of life, and on secondary outcomes, compared to controls. The intervention group showed significantly larger increases at T2 in physical and social functioning, and decreases in fatigue and anxiety, compared to the control group.
Conclusion
TOP seems feasible and seems to increase the quality of life and related aspects in cancer survivors over 1 year. A randomized controlled trial is warranted.
Structure-based design of glycosylated oxytocin analogues with improved selectivity and antinociceptive activity
Authors: Goodman Hannah , Tanguturi Parthasadhireddy , Szabo Lajos , Sprober Sara , Liu Chenxi , Al-Obeidi Fahad , Kumirov Vlad , Heien M. , Streicher John , Polt Robin 
Published: September 2022

Abstract
Pain, both acute and chronic, is often treated with opioids despite severe negative side effects, such as physical dependence, respiratory depression and overdose. In the United States the misuse of opioid analgesics has given rise to the opioid crisis or opioid epidemic. As the frequency of overdoses increases, the need for alternative, non-addictive analgesics has become increasingly urgent. Oxytocin, a pituitary hormone, has shown robust evidence for analgesia and shows promise for treatment and prevention of opioid use disorder. Despite decades of research, clinical implementation is hindered by the poor pharmacokinetic profile of the native hormone oxytocin, which is cyclized by a labile disulfide bond. We addressed this by replacing the disulfide bond with a more stable lactam; additionally, we have glycosylated the cyclic peptides to yield brain penetrant oxytocin analogues. These analogues show exquisite selectivity for the oxytocin receptor and potent in vivo antinociception in mice following peripheral administration, suggesting further study toward clinical applications for pain treatment.
Three-dimensional chaoticons formed by multipole beams in liquid crystal
Authors: zhang lingling , ke lin 
Published: September 2022

Abstract
The propagation characteristics of odd and even Laguerre Gaussian beams in nonlocal nonlinear media are studied numerically. It is found that the Laguerre Gaussian beams of mode (0,1) can propagate stably long distances as soliton. The beams of other modes are unstable and break up rapidly during the propagation. Although the waveforms of other modes distort and the beams may evolve into chaotic state, the broken beams of some modes will form chaoticons. Espesially, the chaoticons which exhibit solitonlike properties can propagate longer distances. The positive maximal Lyapunov exponents and spatial decoherence illustrate the chaotic properties, while the invariance of beam width and beam profile proves that they are chaoticons.
Boundedness of differential transforms for Poisson semigroups generated by Bessel operators
Authors: Zhang Chao 
Published: September 2022

Abstract

Note: Please see manuscript pdf for full abstract with equations.
In this paper we analyze the convergence of the following type of series
\begin{equation*} T_N f(x)=\sum_{j=N_1}^{N_2} v_j\Big(\P_{a_{j+1}} f(x)-\P_{a_{j}} f(x)\Big),\quad x\in \mathbb R_+,\end{equation*}
where $\{\P_{t} \}_{t>0}$ is the Poisson semigroup of the Bessel operator $\displaystyle \Delta_\lambda:=-{d^2\over dx^2}-{2\lambda\over x}{d\over dx}$ with $\lambda$ being a positive constant, $N=(N_1, N_2)\in \mathbb Z^2$ with $N_1