bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektivitas atau Aksesibilitas: Kajian Desain Mal Pelayanan Publik dalam Perspektif Desain Inklusi
Authors: Sholeh Moh Syahru Romadhon , Antaryama I Gusti Ngurah , Noerwasito Vincentius Totok 
Published: November 2022

<p><em><span lang="IN">The SDG's primary target of providing an inclusive environment has a lot to do with the quality of public services. However, in terms of infrastructure, there are still various shortcomings, especially in implementing designs based on inclusive design. Malang City, one of the cities with new public service facilities, chose an existing building to become a public service mall. Issues that occur include unfriendly circulation, inappropriate space functions and not adequately accommodated mobility of users with special needs, elders and children because there is only one access. This research uses a qualitative approach with observation and interviews as a method and the principle of inclusive design as a research tool. The result of the study from this research is that the Mal Pelayanan Publik Merdeka Kota Malang has not yet become an inclusive public facility.</span></em></p>
A comparison of five single-file systems in the preparation of severely curved root canals
Authors: Liu Yina , Chen Meizhi , Tang Weilong , Liu Chang , Du Minquan 
Published: November 2022

Abstract
Background
To evaluate the root canal preparation outcomes achieved by five nickel-titanium single-file instrumentation systems (M3-L, Reciproc Blue, V-Taper 2H, WaveOne Gold, XP-endo Shaper) in severely curved molar root canals.
Methods
A total of 60 root canals were selected from extracted human molar teeth with curvatures ranging from 25° to 50° and divided into five groups based on the instrumentation system employed (n = 12). Before and after root canal preparation, a Micro-CT scan was taken, and pre- and post-operative data were analyzed to evaluate the following parameters: volume increment of root canals (VI), untouched root canal areas (UTA), and canal transportation (CT). Apically extruded debris (AD) was collected during preparation. After that, all samples were separated into two parts and examined respectively by scanning electron microscope (SEM) to assess cleaning ability. Data were statistically analyzed with ANOVA (UTA, AD, VI) or Kruskal-Wallis test (CT, SEM-score), the level of significance was set at α = 0.05.
Results
There were no significant differences between the five systems regarding the AD, VI, and UTA parameters (P > 0.05). In terms of CT, no significant difference was noted at the straight section of canal and apical levels, while XP-endo Shaper showed less canal transportation than M3-L at the level of curved vertex (P < 0.05), and the centering ability of V-Taper 2H was significantly better than WaveOne Gold at the initial point of bending (P < 0.05). Debris and smear layers were present on the canal walls of all specimens, the apical thirds of the canal presented higher SEM scores than the coronal thirds in all groups (P < 0.05). Reciproc Blue and XP-endo Shaper showed fewer smear scores than WaveOne Gold in the apical thirds (P < 0.01 and P < 0.05, respectively), and no statistical difference was found between other groups in the middle and coronal thirds.
Conclusions
The five single-file systems evaluated performed equally in apically debris extrusion, dentin removal, and untouched root canal areas, while XP-endo Shaper and V-Taper 2H resulted in less canal transportation compared to M3-L and WaveOne Gold. Regarding cleaning ability, Reciproc Blue and XP-endo Shaper were associated with less smear layer than WaveOne Gold in the apical thirds.
Vulnerability of cocoa-based agroforestry systems to climate change in West Africa
Authors: Salamanca Antonio Jesús Ariza , Navarro-Cerrillo Rafael Mª , Quero-Pérez José L. , Gallardo-Armas Belinda , Crozier Jayne , Stirling Clare , de Sousa Kauê , González-Moreno Pablo 
Published: November 2022

Abstract
Previous research indicates that some important cocoa cultivated areas in West Africa will become unsuitable for growing cocoa in the next decades. However, it is not clear if this change will be mirrored by the shade tree species that could be used in cocoa-based agroforestry systems (C-AFS). We characterized current and future patterns of habitat suitability for 38 tree species (including cocoa), using a consensus method for species distribution modelling (SDM) considering for the first time climatic and soil variables. The models projected an increase of up to 6% of the potential suitable area for cocoa by 2060 compared to its current suitable area in West Africa. Furthermore, the suitable area was highly reduced (14.5%) once considering only available land-use not contributing to deforestation. Regarding shade trees, 50% of the 37 shade tree species modelled will experience a decrease in geographic rate extent by 2040 in West Africa, and 60% by 2060. Hotspots of shade tree species richness overlap the current core cocoa production areas in Ghana and Côte d’Ivoire, suggesting a potential mismatch for the outer areas in West Africa. Our results highlight the importance of transforming cocoa-based agroforestry systems by changing shade tree species composition to adapt this production systems for future climate conditions.
A novel defined PANoptosis-related miRNA signature for predicting prognosis and immune characteristics in Kidney Renal Clear Cell Carcinoma
Authors: Wang Yanmei , Zhou Jia , Zhang Nan , Zhu Yiran , Zhong Yiming , Wang Zhuo , Jin Hongchuan , Wang Xian 
Published: November 2022

Abstract
Kidney renal clear cell carcinoma (KIRC) is one of the most common malignancies and PANoptosis is a unique inflammatory programmed cell death regulated by the PANoptosome. MicroRNAs (miRNAs) are important regulators of cancer occurrence and progress. However, the potential role of PANoptosis-related miRNAs (PRMs) in KIRC remains elusive. In this study, KIRC samples were collected from The Cancer Genome Atlas database and two Gene Expression Omnibus datasets and PRMs were identified by previous literature reports. Univariate Cox and Lasso Cox regression analyses were applied to identify prognosis PRMs and then construct a PANoptosis-related miRNA prognostic signature evaluated by the risk score. By a variety of R software packages and web analysis tools, we found the high-risk patients bear worse survival prognoses and were significantly associated with high-grade and advanced-stage tumors. Furthermore, we demonstrated the low-risk group had significant changes in metabolic pathways and the high-risk group was characterized by high immune cell infiltration and immune checkpoints expression as well as low IC50 values of chemotherapeutic agents, suggesting that the high-risk patients may benefit more from immunotherapy and chemotherapy. In short, we constructed a PANoptosis-related miRNA signature and revealed its potential significance on the clinicopathological features and tumor immunity, providing new strategies for precise treatment.
Tailoring Exciton-Polariton Emission Lines From Wide-Ranging Monolayer Semiconductors with a Broadband Mie Resonator
Authors: Fang Jie , Yao Kan , Wang Mingsong , Yu Zhuohang , Zhang Tianyi , Jiang Taizhi , Huang Suichu , Korgel Brian , Terrones Mauricio , Alu Andrea , Zheng Yuebing 
Published: November 2022

Abstract
Two-dimensional (2D) exciton-polaritons in monolayer transition metal dichalcogenides (TMDs) exhibit practical advantages in valley coherence, optical nonlinearities, and even bosonic condensation owing to their light emission capability. To achieve robust exciton-polariton emission, strong photon-exciton couplings are required at the TMD monolayer, which is challenging due to its limited thickness. High-quality(Q)-factor optical cavities with narrowband resonances are an effective approach but typically limited to a specific excitonic state of a certain TMD material. Herein, we achieve on-demand exciton-polariton emission for a wide range of monolayer TMDs by hybridizing 2D excitons with broadband Mie resonances spanning the whole visible spectrum. By tightly confining broadband light at the TMD monolayer, our one type of Mie resonator on different TMDs enables enhanced light-matter interactions with multiple excitonic states simultaneously. We demonstrate multi-Rabi splittings and robust polaritonic photoluminescence (PL) in monolayer WSe2, WS2, and MoS2. The hybrid system enables to approach the ultra-strong coupling regime at room temperature.
Recombination-aware phylogenetic analysis sheds light on the evolutionary origin of SARS-CoV-2
Authors: G Luis Roger Esquivel , Weber Ariane , Kocher Arthur , Kühnert Denise 
Published: November 2022

Abstract
SARS-CoV-2 can infect human cells through the recognition of the human angiotensin-converting enzyme 2 (ACE2) receptors. This affinity is given by six amino acid located in the receptor binding domain (RBD) region within the Spike protein. Genetic recombination involving bat and pangolin Sarbecoviruses, and natural selection have been proposed as possible explanations for the acquisition of these amino acids. In this study we employed Bayesian phylogenetics to jointly reconstruct the phylogeny of the RBD among human, bat and pangolin Sarbecoviruses and detect recombination events affecting this region of the genome. A recombination event involving RaTG13, the closest relative of SARS-CoV-2 that lacks five of the six residues, and an unsampled Sarbecovirus lineage was detected. This result suggests that the key amino acids were likely present in the common ancestor of SARS-CoV-2 and RaTG13, with the latter losing five of the amino acids as the result of recombination.
Broad Humoral Immunity Generated in Mice by a Formulation Composed by Two Antigens From Delta Variant of SARS-CoV-2
Authors: Lobaina Yadira , Chen Rong , Suzarte Edith , Ai Panchao , Huerta Vivian , Tan Changyuan , Alvarez-Lajonchere Liz , Liling Yang , Musacchio Alexis , Silva Ricardo , Guillén Gerardo Enrique , Zaixue Jiang , Yang Ke , Perera Yasser , Hermida Lisset 
Published: November 2022

Abstract
Due to the rapid development of new variants of SARS-CoV-2 virus, as well as the real threat of new coronavirus zoonosis events, the development of a preventive vaccine with a broader scope of functionality is highly desirable. Previously, we reported the functionality of a nasal formulation based on the preparation of the nucleocapsid protein with the ODN-39M and combined with RBD, both antigens from Delta variant of SARSCoV-2. This combination induces a cross-reactive immunity in mucosal and systemic compartments until sarbecovirus level. In the present study, we explored the magnitude of the immunity generated in Balb/C mice by the same formulation, but adding alum as adjuvant, so as to enhance the humoral immunity against the two antigens. Animals were immunized with three doses of the bivalent formulation, administered by subcutaneous route. The humoral immunity was tested by ELISA and by a Surrogate of Viral Neutralization test. The cell-mediated immunity was also explored. High levels of antibodies against both antigens (N and RBD) were obtained upon immunization. Additionally, the anti-RBD Abs with neutralizing capacity reacted against the three SARS-CoV-2 variants of RBD assayed, including Omicron. At the same time, the Abs also recognized the nucleocapsid proteins from: SARS-CoV-1 and SARS-CoV-2 Delta and Omicron. Taken together, these results make the bivalent formulation tested, an attractive component of a pancorona vaccine able to broaden the scope of humoral immunity against both antigens. This will be particularly important in the reinforcement of immunity from previously vaccinated and/or infected populations.
Observation of entanglement transition of pseudo-random mixed states
Authors: Liu Tong , Liu Shang , Li Hekang , Li Hao , Huang Kaixuan , Xiang Zhongcheng , Song Xiaohui , Xu Kai , Zheng Dongning , Fan Heng 
Published: November 2022

Abstract
Random quantum states serve as a powerful tool in various scientific fields, including quantum supremacy and black hole physics. It has been theoretically predicted that entanglement transitions may happen for different partitions of multipartite random quantum states, however, the experimental observation of these transitions is still absent. Here, we experimentally demonstrate the entanglement transitions witnessed by negativity on a fully connected 20-qubit superconducting processor. We apply the parallel entangling operations, that significantly decrease the depth of the pseudo-random circuits, to generate pseudo-random pure states of up to 15 qubits. By quantum state tomography of the reduced density matrix of six qubits, we measure the negativity spectra. Then, by changing the sizes of the environment and subsystems, we observe the entanglement transitions that are directly identified by logarithmic entanglement negativities based on the negativity spectra.
In addition, we characterize the randomness of our circuits by measuring the distance between the distribution of output bit-string probabilities and the Porter-Thomas distribution. Our results show that the superconducting processor with all-to-all connectivity behaves a promising platform in generating random states and understanding the entanglement structure for multipartite quantum systems.
Effect of diosimin combined with ulinastatin on renal injury markers and renal ultrasound indicators in patients with delayed renal function recovery after transplantation
Authors: Yuan Ming , Qi Baoyu , Meng Qingyi 
Published: November 2022

Abstract
Backgroud: Renal transplantation, as an effective treatment for end-stage renal disease, has many clinical complications, among which delayed graft function recovery (DGF), as one of the common postoperative complications, is also a major risk factor affecting the short-term and long-term efficacy of renal transplantation. Therefore, reasonable use of DGF after renal transplantation to promote renal function recovery is of great significance for the prognosis of these patients.
Methods: Based on this, 62 patients who underwent renal transplantation and developed DGF in our hospital from June 2018 to December 2021 were selected as the research objects. According to the random color method, they were divided into three groups: diosimin group (n=20), ulinastatin group (n=21), and combination group (n=21). To observe the effects of different medication regimens on renal injury markers and renal ultrasound related indexes in patients with DGF, and to lay a theoretical foundation for guiding clinical medication and improving prognosis of DGF patients.
Results: After comparing the general data of the three groups, it was found that there was no significant difference (P > 0.05), indicating that there was no difference in medication results due to personal factors. The levels of Scr, CysC and BUN in the ulinastatin group after treatment were significantly better than those before treatment. The levels of renal injury markers in the combined group were significantly better after treatment than before treatment. According to the ultrasound results, there was no significant difference in the renal ultrasound indexes between the diosimine and ulinastatin groups after treatment, while the renal ultrasound indexes of the combined group were better than those of the other two groups.
Conclusion: It can be concluded from the results that diosimin combined with ulinastatin can significantly reduce renal injury in patients with DGF, and can effectively improve renal function in such patients, which has a positive effect on improving prognosis.
Toll-like receptor mediated inflammation directs B cells towards protective antiviral extrafollicular responses
Authors: Lam Jonathan , Baumgarth Nicole 
Published: November 2022

Abstract
Extrafollicular plasmablast responses (EFRs) are considered to generate antibodies of low affinity that offer little protection from infections. Paradoxically, high avidity antigen-B cell receptor engagement is thought to be the main driver of B cell differentiation, whether in EFRs or the slower-developing germinal centers (GCs). This study demonstrates that influenza infection rapidly induced EFRs generating protective antibodies in a B cell intrinsic and extrinsic Toll-like receptor (TLR)-dependent manner. B cell-intrinsic TLR signals supported antigen-stimulated B cell survival, clonal expansion, and the differentiation of B cells via induction of IRF4, the master regulator of B cell differentiation, through activation of NF-kB c-Rel. Provision of sustained TLR4 stimulation after immunization altered the fate of virus-specific B cells towards EFRs instead of GCs, accelerating rapid antibody production and improving their protective capacity over antigen/alum administration alone. Thus, inflammatory signals act as B cell fate-determinants for the rapid generation of protective, antiviral EF responses.
Preparation, characterization, and evaluation of the antitumor effect of kaempferol nanosuspensions
Authors: He Wen , Zhang Junfeng , Ju Jiale , Wu Yinghua , Zhang Yuxi , Zhan Lin , Li Chenchen , Wang Yanli 
Published: November 2022

Abstract
Kaempferol (KAE) is a natural flavonoid compound with antitumor activity. However, the low aqueous solubility, poor chemical stability and suboptimal bioavailability greatly restricted its clinical application of cancer. In order to overcome these shortages and enhance the antitumor effect of KAE, we developed a kaempferol nanosuspensions (KAE-NSps) with D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) as stabilizer, screened the optimal preparation process, and investigated the basic properties and the antitumor effect in the study. The results demonstrated that the particle size was 186.6 ± 2.6 nm of the TPGS-KAE-NSps optimized, the shape of which was fusiform under the transmission electron microscope. The 2% (w/v) glucose was used as the cryoprotectant for TPGS-KAE-NSps, whose drug loading content was 70.31 ± 2.11%, and the solubility was improved prominently compared to KAE. The stability and biocompatibility of TPGS-KAE-NSps were favorable, which had a certain sustained release effect. Moreover, TPGS-KAE-NSps clearly seen to be taken in the cytoplasm exhibited a stronger cytotoxicity and suppression of cell migration, higher apoptosis rate and more intracellular ROS production compared to KAE in vitro cell experiments. In addition, TPGS-KAE-NSps showed a stronger inhibition of tumor growth (the tumor inhibition rate of high dose intravenous injection group was 68.9 ± 1.46%) than KAE with no obvious toxicity on 4T1 tumor-bearing mice. Overall, TPGS-KAE-NSps prepared improved the defect and the antitumor effect of KAE notably, which was a promising nanodrug delivery system for KAE and was expected to become a clinical antitumor drug.
Urban Tram Track Obstacle Detection Algorithm based on BF-SSD
Authors: Yunming Wang , Peng Guodu , Li Weidong , Chu Xianwu 
Published: November 2022

Abstract
In order to improve the detection accuracy of urban tram track obstacles running in complex environments, a track obstacle detection algorithm based on BF-SSD is proposed. Design convolutional splitting structure, replace all 3*3 convolutional layers in VGG16 except the first convolutional layer, improve the detection speed, design two-way fusion modules, strengthen the feature expression ability of the low-level feature layer, improve the detection accuracy of small targets, design a two-stage deconvolution module, make up for the noise information generated by the high-level feature layer due to excessive deconvolution, enhance the detection effect in harsh environments, propose to improve NMS, and improve the detection ability of coincident targets. Through the test and analysis of the obstacle image dataset of the self-made normal environment and the harsh environment, the experimental results show that compared with other algorithms, the loss function of the BF-SSD algorithm is the lowest, and the mAP of the BF-SSD algorithm reaches 90.03% and 87.83% respectively under normal weather and bad weather environments, and the mAP of the detection of small targets reaches 70.26% and 69.26%, respectively. The BF-SSD algorithm improves the detection accuracy of tram obstacles, especially the detection ability of small target obstacles.
Corrosion protection of carbon steel by methoxy naphthylbithiophene derivatives in acidic medium: Electrochemical, surface characterization and computational approaches
Authors: Fouda Abd El-Aziz S. , Etaiw Safaa-Eldin H. , Ismail Mohamed A. , El-Aziz Dina M. Abd , Eladl Mohamed M. 
Published: November 2022

Abstract
The inhibition efficiency and adsorption affinity were investigated for two novel compounds, namely: 6-methoxy-2-naphthyl-[2, 2’-bithiophene]-5-carboxamidine hydrochloride salt (MA-1440) and 5'-(4-chlorophenyl)-2, 2’-bifuran-5-carboxamidine hydrochloride salt (MA-1456). The inhibition study was conducted on carbon steel surface in 1.0 M HCl with different inhibitor doses and different temperature levels, to investigate the optimum dose and preferable temperature. The performed investigation included chemical, electrochemical, instrumental, and quantum computation techniques. A chemical technique was accomplished by using weight-loss measurements. Different factors were studied using weight-loss measurements in order to reach the maximum inhibition efficiency. The adsorption study revealed that the examined inhibitors obey the Langmuir adsorption isotherm and are chemically adsorbed on the steel surface. The electrochemical measurements were accomplished through the electrochemical impedance (EIS) and potentiodynamic polarization (PDP) techniques. Based on the electrochemical measurements, the examined compounds were categorized as mixed inhibitors. The instrumental examination using different techniques namely: scanning electron microscope (SEM), energy dispersive X-ray (EDX), Fourier-transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS) confirmed that the considered inhibitors are excellently adsorbed over the carbon steel surface. The extent of the adsorption affinity of these compounds on the carbon steel surface was studied theoretically using quantum computations and Monte Carlo simulation. The theoretical investigation results of quantum chemistry were validated with those obtained by chemical and electrochemical methodologies. All investigations prove that, the tested compounds were adsorbed chemically on the steel surface and achieved maximum inhibition efficiency of, 94.69% and 90.85% for M-1440 and MA-1456, respectively, at the optimum concentration 3010-6 mol. L-1 and temperature 328 K.