bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMBERDAYAAN PERGURUAN TINGGI DALAM RANGKA IMPLEMENTASI MERDEKA BELAJAR, KAMPUS MERDEKA SEBAGAI EVALUASI PENDIDIKAN KARAKTER DIMASA PANDEMI (PKM Pada Perguruan Tinggi Kota Surakarta Jawa Tengah)
Authors: Wartoyo Wartoyo , Trisiana Anita 
Published: June 2022

Pelaksanaan pendidikan karakter saat ini di masa Pandemi dirasakan sangat terasa berbeda sekali. Perubahan yang sangat frontal terjadi dalam pembelajaran, dan ada perubahan tatanan nilai yang menjadi bagian dari penerapan pendidikan karakter. Gambaran situasi masyarakat bahkan situasi dunia pendidikan di Indonesia menjadi motivasi pokok mainstreaming implementasi pendidikan karakter di Indonesia. Pentingnya pengembangan pendidikan karakter ini gayung bersambut dengan implementasi Merdeka Belajar Kampus Merdeka (MBKM). Untuk itu Perguruan Tinggi memiliki peran yang sangat strategis untuk mengupayakan evaluasi pendidikan karakter dimasa pandemi, sebagai salah satu wujud dukungan dari pemberdayaan kampus merdeka belajar. Khalayak sasaran dalam program kemitraan masyarakat ini adalah Masyarakat Non Produktif, yaitu Perguruan Tinggi di Kota Surakarta. Khalayak sasaran tersebut dijadikan sebagai Kampus Merdeka Belajar yang memerlukan pemberdayaan pendidikan dan pelatihan berupa kegiatan evaluasi pendidikan karakter sebagai salah satu kegiatan yang akan menopang dan menyaring permasalahan konflik sosio- kultur yang muncul dalam masyarakat sehingga ketentraman dan kenyamanan akan tercapai dalam kehidupan masyarakat. Hasil kegiatan pengabdian menunjukan bahwa perguruan tinggi menindaklanjuti kebiajakan MBKM, yang kemudian melakukan beberapa program kegiatan yang mendukung evaluasi pendidikan karakter melalui integrasi dari berbagai kebijakan yang dimiliki, sebagaimana adanya kebiajakn 4A (Anti: Korupsi, Intoleransi, Kekerasan Seksual, Perudungan). Seperti di Universitas Slamet Riyadi Kebijakan 4A tersebut dikembangkan menjadi 6A, dengan tambahan Anit: Narkoba, dan Radikalisme, Terorisme. Untuk itu masing-masing PT mampu meningkatkan dan memberikan pelayanan, dan pemberdayaan masyarakat khususnya pengembangan IPTEK di Perguruan Tinggi.Kata kunci: Pemberdayaan; Merdeka Belajar; Pendidikan Karakter
Analisis Kemampuan Pemecahan Masalah Matematis Siswa SMA pada Materi Barisan dan Deret Geometri
Authors: Damayanti Nofita , Kartini Kartini 
Published: June 2022

AbstrakKemampuan pemecahan masalah matematis merupakan salah satu kemampuan matematis yang perlu dimiliki oleh siswa. Penelitian ini bertujuan untuk menganalisis kemampuan pemecahan masalah matematis siswa dalam menyelesaikan permasalahan kontekstual pada materi barisan dan deret geometri. Jenis penelitian ini adalah penelitian kuantitatif. Teknik pengumpulan data yang digunakan adalah teknik tes dan wawancara secara luring. Subjek penelitian yaitu 19 siswa kelas XI MIA SMA Nurul Falah tahun ajaran 2020/2021. Analisis terhadap kemampuan pemecahan masalah matematis siswa diihat melalui indikator yaitu memahami masalah, merencanakan penyelesaian masalah, melaksanakan rencana penyelesaian masalah, dan menafsirkan hasil yang diperoleh. Hasil analisis kemampuan pemecahan masalah matematis siswa menunjukkan bahwa sebanyak 75,3% siswa telah memiliki kemampuan untuk memahami masalah yang disajikan dengan baik. Sementara itu, hanya 15,70% siswa yang melakukan penafsiran hasil yang perhitungan yang diperoleh. Analysis of Mathematical Problem-Solving Ability of High School Students on the Geometric Sequences and Series AbstractMathematical problem-solving ability is one of the mathematical abilities which students must have. This research aims to analyze mathematical problem-solving ability in solving contextual problems on geometric sequences and series. This research is explorative research with qualitative and quantitative approaching. The data collection technique used was an offline test and face-to-face interview techniques. The subject of this research is 19 students of class XI MIA SMA Nurul Falah year 2020/2021. Analysis of students’ mathematical problem-solving ability is seen through four indicators, namely: understanding the problem, planning the problem solving, implementing the problem-solving plans, and interpreting the obtained result. The result of this research shows that 75,3% of students already can understand the problem. Meanwhile, only 15,70% of students interpret the result of the calculations.
Understanding Xinjiang from a Chinese Nationalist’s Perspective
Authors: Aryodiguno Harryanto 
Published: June 2022

<p>This paper focuses on the Xinjiang conflict with the central government as one of the conflicts that have sparked the world's attention, especially in western countries. Western media spend their most effort on discussing Vocational Education and Training Centers, political issues, religion, idealism, and human rights in Xinjiang. And then, under the presuppositions of Western-Centrism, the Western media accuses China of violating human rights. However, the Chinese government emphasizes that what happened in Xinjiang is the unrest that has been happening because of the group that wants to separate from China. This paper seeks to explain the real events in Xinjiang, including the problems faced by Xinjiang and the Chinese government, culture, politics, and the psychology behind the western media.</p><p> </p><p><strong>Keywords: Western-Centralism, Xinjiang, Uyghur, Islam, Politic</strong></p>
Educação para a diversidade cultural: reflexões sobre as influências internacionais na atual política educacional
Authors: Carvalho Elma Júlia Gonçalves de , Faustino Rosangela Célia 
Published: June 2022

As políticas educacionais voltadas para o reconhecimento e a valorização da diversidade cultural, influenciadas por organismos e organizações internacionais, têm ocupado lugar central nas definições governamentais dos diferentes países nas últimas décadas. Considerando o contexto de crise econômica do sistema capitalista, das reformas neoliberais, da reestruturação produtiva e da fragmentação das lutas sociais que se mobilizam em torno das especificidades e diferenças, o objetivo neste texto é discutir, por meio da análise de documentos internacionais e nacionais, as motivações sociais e históricas desta política, bem como da busca da construção do consenso envolvendo temas como a valorização cultural e a inclusão social.
A construção da mulher-mãe-monstro: o infanticídio tornado espetáculo na mídia
Authors: Dos Santos Katia Alexsandra , Tfouni Leda Verdiani 
Published: June 2022

Este artigo apresenta uma análise de manchetes de notícias sobre infanticídio, divulgadas em portais de notícias na internet. Tivemos como objetivo observar, a partir da Análise do Discurso, de alguns pressupostos foucaultianos e da noção de espetacularização, os efeitos produzidos por tais manchetes no que se refere ao lugar instituído para a mulher que pratica esse tipo de crime. A partir da análise empreendida, percebemos a construção do que chamamos de mulher-mãe-monstro, dada como um a priori, a despeito das condições de produção. Tal efeito se sustenta pelo processo de espetacularização produzido pelas notícias e pela mídia, de um modo geral, que toma casos particulares, da instância privada, e transforma em evento público, espetáculo.
Plasmalogen Loss in Sepsis and SARS-CoV-2 Infection
Authors: Pike Daniel P. , McGuffee Reagan M. , Geerling Elizabeth , Albert Carolyn J. , Hoft Daniel F. , Shashaty Michael G. S. , Meyer Nuala J. , Pinto Amelia K. , Ford David A. 
Published: June 2022

Plasmalogens are plasma-borne antioxidant phospholipid species that provide protection as cellular lipid components during cellular oxidative stress. In this study we investigated plasma plasmalogen levels in human sepsis as well as in rodent models of infection. In humans, levels of multiple plasmenylethanolamine molecular species were decreased in septic patient plasma compared to control subject plasma as well as an age-aligned control subject cohort. Additionally, lysoplasmenylcholine levels were significantly decreased in septic patients compared to the control cohorts. In contrast, plasma diacyl phosphatidylethanolamine and phosphatidylcholine levels were elevated in septic patients. Lipid changes were also determined in rats subjected to cecal slurry sepsis. Plasma plasmenylcholine, plasmenylethanolamine, and lysoplasmenylcholine levels were decreased while diacyl phosphatidylethanolamine levels were increased in septic rats compared to control treated rats. Kidney levels of lysoplasmenylcholine as well as plasmenylethanolamine molecular species were decreased in septic rats. Interestingly, liver plasmenylcholine and plasmenylethanolamine levels were increased in septic rats. Since COVID-19 is associated with sepsis-like acute respiratory distress syndrome and oxidative stress, plasmalogen levels were also determined in a mouse model of COVID-19 (intranasal inoculation of K18 mice with SARS-CoV-2). 3 days following infection, lung infection was confirmed as well as cytokine expression in the lung. Multiple molecular species of lung plasmenylcholine and plasmenylethanolamine were decreased in infected mice. In contrast, the predominant lung phospholipid, dipalmitoyl phosphatidylcholine, was not decreased following SARS-CoV-2 infection. Additionally total plasmenylcholine levels were decreased in the plasma of SARS-CoV-2 infected mice. Collectively, these data demonstrate the loss of plasmalogens during both sepsis and SARS-CoV-2 infection. This study also indicates plasma plasmalogens should be considered in future studies as biomarkers of infection and as prognostic indicators for sepsis and COVID-19 outcomes.
Suicide and Cardiovascular Death Among Patients With Multiple Primary Cancers in the United States
Authors: Su Chen , Wang Yan , Wu Fang , Qiu Yumin , Tao Jun 
Published: June 2022

BackgroundPrevious studies have demonstrated that patients with a cancer diagnosis have an elevated risk of suicide and cardiovascular death. However, the effects of the diagnosis of multiple primary cancers (MPCs) on the risk of suicide and cardiovascular death remain unclear. This study aimed to identify the risk of suicide and cardiovascular death among patients with MPCs in the United States.MethodsPatients with a single or MPC(s) between 1975 and 2016 were selected from the Surveillance, Epidemiology, and End Results database in a retrospective cohort study. Mortality rates and standardized mortality ratios (SMRs) of suicides and cardiovascular diseases among patients with MPCs were estimated.ResultsOf the 645,818 patients diagnosed with MPCs included in this analysis, 760 and 36,209 deaths from suicides and cardiovascular diseases were observed, respectively. The suicide and cardiovascular-disease mortality rates were 1.89- (95% CI, 1.76–2.02) and 1.65-times (95% CI, 1.63–1.67), respectively, that of the general population. The cumulative mortality rate from both suicides and cardiovascular diseases among patients with MPCs were significantly higher than those of patients with a single primary cancer (Both p &lt; 0.001). In patients with MPCs diagnosed asynchronously, the cumulative incidence rates of suicides and cardiovascular deaths were higher than those diagnosed synchronously. Among all MPCs, cancers of the pancreas and esophagus had the highest SMRs of suicide (5.98 and 5.67, respectively), while acute myeloid leukemia and brain cancer had the highest SMRs of cardiovascular diseases (3.87 and 3.62, respectively). The SMR of suicide was highest within 1 year after diagnosis, while that of cardiovascular diseases was highest 5 years after diagnosis.ConclusionsThis study showed that the mortality rates from suicides and cardiovascular diseases among patients with MPCs were higher than those with a single primary cancer. Therefore, our results underscore the need for psychological assessment and targeted preventive interventions for suicides and cardiovascular diseases among patients with MPCs.
Study of the Statistical Characteristics of Artificial Source Signals Based on the CSES
Authors: Huang Jianping , Jia Juan , Yin Huichao , Li Zhong , Li Jinwen , Shen Xuhui , Zhima Zeren 
Published: June 2022

The ground-based artificial source electromagnetic signal transmitted to space will form a pair of intensity regions over the station and its conjugate point. In order to study the position and intensity of the strongest points in the two regions, the power-spectrum density (PSD) of the electric field on board the Zhangheng-1 satellite (CSES) was selected when it passed over the NWC artificial source transmitting station. The selected frequency is centered at 19.8 kHz with a bandwidth of 200 Hz. The strongest point is defined as the location with the maximum power spectral density of ±10° around the NWC station within 5 days, which is the revisiting period of the CSES. The results show that statistical characteristics of strongest points vary as day/night, local/conjugate point, longitude/latitude, and different components of electric field vectors. In terms of longitude deviation, it is mostly westward offset at night and on both sides in the day over the NWC but opposite at the conjugate point. In terms of latitude deviations, it is equator-ward at night and the same during the day with a smaller deviation. While over the conjugate point, it is northward offset in the day and both at night with a bigger offset. In terms of intensity, it is stable without obvious seasonal changes over the NWC and its conjugate point. The intensity of PSD is higher at night than during the day. For the PSD intensity of the three components, the descending order over the NWC is Ead, Eab, and Ecd at night and Ecd, Ead, and Eab in the day, and the opposite is true for over the conjugate point.
Artificial Regulation Effect of Plant Retardants on Leaf Anatomical Characteristics of Elaeagnus Angustifolia
Authors: Zhang Chao , Li Wanjiao , Gao Yong , Xu Zhengzheng , Tian Xiaoning 
Published: June 2022

Aims: In order to explore the adaptation mechanisms of Elaeagnus angustifolia to the arid environment in desert areas under the treatment of artificial plant retardants, we used to investigate artificial regulation by using retardants of paclobutrazol (PP333), paclobutrazol+adhesive (NPP333), and chlormequat (CCC) based on multiple factors and multiple levels.Methods: Orthogonal experimental design of L9 (34) was used to design the experimental treatment combinations. Leaf morphological and structural characteristics determined by the paraffin section method were used to explain the effect of different treatments and their combinations.Results: The leaves of Elaeagnus angustifolia were iso-petalous with obvious stellate epidermal fuzzy borders on the upper epidermis. The palisade tissue was well developed and tightly arranged. The T1-T9 treatment significantly increased leaf thickness. Conversely, leaf length and width showed a delayed growth effect, while leaf growth developed as an elongated type after application. After plant retardant control, the upper epidermal, palisade tissue, and spongy tissue thickness of the leaves showed a significant trend to increase, at the same time, the number of xylem rows increased and the number of cells per row increased and were arranged closely. Meanwhile, there was a synergistic evolution phenomenon among the indexes. The best treatment combination of plant retardants to regulate the leaf configuration of plants was selecting the concentration of 600 mg/L of PP333, using the root application + leaf application method for two applications.Conclusions: The study showed that plant retardants improved the ability of plants to resist external environmental stress by reducing leaf area, increasing leaf and epidermal thickness, and promoting the development of mesophyll and vein structures in order to improve water retention capacity and prevent transitional transpiration.
p53 Regulates a miRNA-Fructose Transporter Axis in Brown Adipose Tissue Under Fasting
Authors: Reinisch Isabel , Klymiuk Ingeborg , Michenthaler Helene , Moyschewitz Elisabeth , Galhuber Markus , Krstic Jelena , Domingo Magnus , Zhang Fangrong , Karbiener Michael , Vujić Nemanja , Kratky Dagmar , Schreiber Renate , Schupp Michael , Lenihan-Geels Georgia , Schulz Tim J. , Malli Roland , Madl Tobias , Prokesch Andreas 
Published: June 2022

Active thermogenic adipocytes avidly consume energy substrates like fatty acids and glucose to maintain body temperature upon cold exposure. Despite strong evidence for the involvement of brown adipose tissue (BAT) in controlling systemic energy homeostasis upon nutrient excess, it is unclear how the activity of brown adipocytes is regulated in times of nutrient scarcity. Therefore, this study aimed to scrutinize factors that modulate BAT activity to balance thermogenic and energetic needs upon simultaneous fasting and cold stress. For an unbiased view, we performed transcriptomic and miRNA sequencing analyses of BAT from acutely fasted (24 h) mice under mild cold exposure. Combining these data with in-depth bioinformatic analyses and in vitro gain-of-function experiments, we define a previously undescribed axis of p53 inducing miR-92a-1-5p transcription that is highly upregulated by fasting in thermogenic adipocytes. p53, a fasting-responsive transcription factor, was previously shown to control genes involved in the thermogenic program and miR-92a-1-5p was found to negatively correlate with human BAT activity. Here, we identify fructose transporter Slc2a5 as one direct downstream target of this axis and show that fructose can be taken up by and metabolized in brown adipocytes. In sum, this study delineates a fasting-induced pathway involving p53 that transactivates miR-92a-1-5p, which in turn decreases Slc2a5 expression, and suggests fructose as an energy substrate in thermogenic adipocytes.
Feasibility of Extracting Meaningful Patient Centered Outcomes From the Electronic Health Record Following Critical Illness in the Elderly
Authors: Ahmad Sumera R. , Tarabochia Alex D. , Budahn Luann , Lemahieu Allison M. , Anderson Brenda , Vashistha Kirtivardhan , Karnatovskaia Lioudmila , Gajic Ognjen 
Published: June 2022

BackgroundMeaningful patient centered outcomes of critical illness such as functional status, cognition and mental health are studied using validated measurement tools that may often be impractical outside the research setting. The Electronic health record (EHR) contains a plethora of information pertaining to these domains. We sought to determine how feasible and reliable it is to assess meaningful patient centered outcomes from the EHR.MethodsTwo independent investigators reviewed EHR of a random sample of ICU patients looking at documented assessments of trajectory of functional status, cognition, and mental health. Cohen's kappa was used to measure agreement between 2 reviewers. Post ICU health in these domains 12 month after admission was compared to pre- ICU health in the 12 months prior to assess qualitatively whether a patient's condition was “better,” “unchanged” or “worse.” Days alive and out of hospital/health care facility was a secondary outcome.ResultsThirty six of the 41 randomly selected patients (88%) survived critical illness. EHR contained sufficient information to determine the difference in health status before and after critical illness in most survivors (86%). Decline in functional status (36%), cognition (11%), and mental health (11%) following ICU admission was observed compared to premorbid baseline. Agreement between reviewers was excellent (kappa ranging from 0.966 to 1). Eighteen patients (44%) remained home after discharge from hospital and rehabilitation during the 12- month follow up.ConclusionWe demonstrated the feasibility and reliability of assessing the trajectory of changes in functional status, cognition, and selected mental health outcomes from EHR of critically ill patients. If validated in a larger, representative sample, these outcomes could be used alongside survival in quality improvement studies and pragmatic clinical trials.
Circ_0004951 Promotes Pyroptosis of Renal Tubular Cells via the NLRP3 Inflammasome in Diabetic Kidney Disease
Authors: Wang Yulin , Ding Li , Wang Ruiqiang , Guo Yanhong , Yang ZiJun , Yu Lu , Wang LiuWei , Liang Yan , Tang Lin 
Published: June 2022

BackgroundDiabetic kidney disease (DKD) has become the leading cause of chronic kidney disease (CKD) in many countries. Recent studies have shown that circular RNA and pyroptosis play an important role in pathogenesis of DKD.MethodsWe analyzed expression patterns of circRNAs in human kidney biopsy tissues obtained from type 2 DKD (n = 9) and nephrectomy (n = 9) patients. Next, we cultured human renal tubular epithelial cells (HK2) in high glucose condition and detected circ_0004951, miR-93-5p, NLR Pyrin Domain Containing 3 (NLRP3) inflammasome-related indicators and pyroptosis. Furthermore, we performed Bioinformatics analysis and dual-luciferase reporter assay to analyze the relationship among circ_0004951, miR-93-5p and NLRP3.ResultsCirc_0004951 was significantly upregulated in kidney tissues from DKD patients and HK2 in high glucose condition vs. control. Knockdown of circ_0004951 mediated a significant suppression of HK2 pyroptosis, while results from bioinformatics analysis revealed that circ_0004951 has binding sites with miR-93-5p and miR-93-5p could bind to NLRP3. Results from dual-luciferase reporter assay further corroborated this finding. Finally, observations from rescue experiments showed that down-regulation of miR-93-5p and upregulation of NLRP3 markedly attenuated the anti-pyroptosis and anti-inflammatory effects of circ_0004951 knockdown on HK2.ConclusionCirc_0004951 promotes pyroptosis of renal tubular epithelial cells in DKD via the miR-93-5p/NLRP3 inflammasome pathway, suggesting its potential for clinical diagnosis and treatment of DKD.
Depressed Kallikrein Generation in Women With Preeclampsia: A Matched Cross-Sectional Study
Authors: Godtfredsen Anne Cathrine , Gram Jørgen Brodersen , Pham Stephanie Thuy Duong , Dolleris Britta Blume , Jørgensen Jan Stener , Sidelmann Johannes Jakobsen , Palarasah Yaseelan 
Published: June 2022

ObjectiveThe pathophysiology of preeclampsia is not fully understood. Disturbances in the contact system are associated with preeclampsia. Few studies have investigated the association between preeclampsia and alterations in the contact system in plasma. This study aims to elucidate whether this basic biological system is affected in preeclampsia using new methods focusing on the dynamic interactions and total capacity of the contact system in blood.DesignCross-sectional study matching women with preeclampsia and controls without preeclampsia regarding age, pregestational body mass index, and gestational age at onset of the disease.SettingTwo Danish University hospitals.SampleA cohort of 117 women with preeclampsia and 117 controls.MethodsThe turnover and capacity of the contact system were determined with new methods. Paired t-test, Wilcoxon signed-pairs signed rank test, Mann-Whitney or Chi2-test were applied, as appropriate.Main Outcome MeasurementsKallikrein generation (peak kallikrein concentration and endogenous kallikrein potential), coagulation factor XII, prekallikrein, H-kininogen, cleaved H-kininogen, and complement C1 esterase inhibitor.ResultsThe endogenous kallikrein potential, peak kallikrein concentration, prekallikrein and cleaved H-kininogen were significantly lower in women with preeclampsia compared to the controls, p ≤ 0.005, whereas the concentration of coagulation factor XII, H-kininogen and complement C1 esterase inhibitor was not significantly different, p &gt; 0.05.ConclusionThis study demonstrates significant reduction in kallikrein generating capacity, prekallikrein and cleaved H-kininogen indicating that the contact system is affected in preeclampsia suggesting a link to the pathophysiology of the disease.