bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards the development of a diagnostic test for autism spectrum disorder: Big data meets metabolomics
Authors: Qureshi Fatir , Hahn Juergen 
Published: August 2022

AbstractAutism spectrum disorder (ASD) is defined as a neurodevelopmental disorder that results in impairments in social communications and interactions as well as repetitive behaviours. Despite current estimates showing that approximately 2.2% of children are affected in the United States, relatively little about ASD pathophysiology is known in part due to the highly heterogenous presentation of the disorder. Given the limited knowledge into the biological mechanisms governing its aetiology, the diagnosis of ASD is performed exclusively based on an individual's behaviour assessed by a clinician through psychometric tools. Although there is no readily available biochemical test for ASD diagnosis, multivariate statistical methods show considerable potential for effectively leveraging multiple biochemical measurements for classification and characterization purposes. In this work, markers associated with the folate dependent one‐carbon metabolism and transsulfuration (FOCM/TS) pathways analyzed via both Fisher discriminant analysis and support vector machine showed a strong capability to distinguish between ASD and typically developing peers (TD) cohorts. Furthermore, using kernel partial least squares regression it was possible to assess some degree of behavioural severity from metabolomic data. While the results presented need to be replicated in independent future studies, they represent a promising avenue for uncovering clinically relevant ASD biomarkers.
Oxidative physiology is weakly associated with pigmentation in birds
Authors: Marton Attila , Vágási Csongor I. , Vincze Orsolya , Bókony Veronika , Pap Péter L. , Pătraș Laura , Pénzes Janka , Bărbos Lőrinc , Fülöp Attila , Osváth Gergely , Ducatez Simon , Giraudeau Mathieu 
Published: August 2022

AbstractThe mechanistic link between avian oxidative physiology and plumage coloration has attracted considerable attention in past decades. Hence, multiple proximal hypotheses were proposed to explain how oxidative state might covary with the production of melanin and carotenoid pigments. Some hypotheses underscore that these pigments (or their precursors, e.g., glutathione) have antioxidant capacities or function as molecules storing the toxic excess of intracellular compounds, while others highlight that these pigments can act as pro‐oxidants under specific conditions. Most studies addressing these associations are at the intraspecific level, while phylogenetic comparative studies are still scarce, though needed to assess the generality of these associations. Here, we tested whether plumage and bare part coloration were related to oxidative physiology at an interspecific level by measuring five oxidative physiology markers (three nonenzymatic antioxidants and two markers of lipid peroxidative damage) in 1387 individuals of 104 European bird species sampled during the breeding season, and by scoring plumage eumelanin, pheomelanin, and carotenoid content for each sex and species. Only the plasma level of reactive oxygen metabolites was related to melanin coloration, being positively associated with eumelanin score and negatively with pheomelanin score. Thus, our results do not support the role of antioxidant glutathione in driving variation in melanin synthesis across species. Furthermore, the carotenoid scores of feathers and bare parts were unrelated to the measured oxidative physiology parameters, further suggesting that the marked differences in pigmentation across birds does not influence their oxidative state.
Seasonal and ontological variation in diet and age‐related differences in prey choice, by an insectivorous songbird
Authors: Davies Sarah R. , Vaughan Ian P. , Thomas Robert J. , Drake Lorna E. , Marchbank Angela , Symondson William O. C. 
Published: August 2022

AbstractThe diet of an individual animal is subject to change over time, both in response to short‐term food fluctuations and over longer time scales as an individual ages and meets different challenges over its life cycle. A metabarcoding approach was used to elucidate the diet of different life stages of a migratory songbird, the Eurasian reed warbler (Acrocephalus scirpaceus) over the 2017 summer breeding season in Somerset, the United Kingdom. The feces of adult, juvenile, and nestling warblers were screened for invertebrate DNA, enabling the identification of prey species. Dietary analysis was coupled with monitoring of Diptera in the field using yellow sticky traps. Seasonal changes in warbler diet were subtle, whereas age class had a greater influence on overall diet composition. Age classes showed high dietary overlap, but significant dietary differences were mediated through the selection of prey; (i) from different taxonomic groups, (ii) with different habitat origins (aquatic vs. terrestrial), and (iii) of different average approximate sizes. Our results highlight the value of metabarcoding data for enhancing ecological studies of insectivores in dynamic environments.
Diversity beyond demographics: Environmental worldviews of forestry and natural resource undergraduate students
Authors: Cruz Sativa , Batavia Chelsea , Arismendi Ivan , Spalding Ana , Nelson Michael Paul 
Published: August 2022

AbstractIn US academic institutions, efforts often concentrate on enhancing the recruitment of students from underrepresented groups, focusing on gender and/or race. However, little attention has been paid to nondemographic forms of diversity, such as environmental worldviews (i.e., differences in the metaphysical, epistemological, and ethical beliefs that define how humans view, value, and interact with the natural world). Here, we present an exploratory measure of environmental worldview diversity among undergraduate students enrolled in natural resource‐related programs. We tested our procedure at Oregon State University, a large public land‐grant university in the United States. Many students reported metaphysical, epistemological, and/or ethical beliefs that deviate from what has been philosophically characterized as the dominant western worldview of natural resources (anthropocentric, dualistic, hierarchical, utilitarian, and mechanistic). Our results suggest that, although forestry students' environmental worldviews are in some ways more closely aligned with the dominant western worldview than other students in natural resources, generally student worldviews reflect a long‐term generational shift away from a strict resource‐commodity value orientation, as documented in the past research. Our findings highlight the importance of considering environmental worldviews as a dimension of diversity within the new generation of natural resource students. Future efforts toward understanding these levels of difference can be important assets in designing programs that appeal to a wide variety of students, ultimately helping efforts to recruit and retain a diverse pool of aspiring natural resource professionals.
Synthesis, Structure and Thermal Properties of Volatile Indium and Gallium Triazenides**
Authors: Samii Rouzbeh , Buttera Sydney C. , Kessler Vadim , O'Brien Nathan J. 
Published: August 2022

AbstractIndium and gallium nitride are important semi‐conductor materials with desirable properties for high‐frequency and power electronics. We have previously demonstrated high‐quality ALD grown InN and GaN using the hexacoordinated 1,3‐diisopropyltriazenide In(III) and Ga(III) precursors. Herein we report the structural and thermal properties their analogues employing combinations of isopropyl, sec‐butyl and tert‐butyltriazenide alkyl groups on the exocyclic nitrogen of the triazenide ligand. The new triazenide compounds were all found to be volatile (80‐120 °C, 0.5 mbar) and showed very good thermal stability (200 and 300 °C). These new triazenide analogues provide a set of precursors whose thermal properties are determined and can be accordingly tailored by strategic choice of exocyclic nitrogen alkyl substituents.
Six‐Component Reactions and Beyond: The Nuts and Bolts
Authors: Hooshmand Seyyed Emad , Yazdani Hossein , Hulme Christopher 
Published: August 2022

AbstractThe deployment of multicomponent reactions (MCRs), defined as containing three or more reactants, not only enjoys pot, atom, and step‐economy in the synthesis of novel complex molecules but also aligns with sustainable chemistry principles as a green symphony. Generally, more components lead to more complexity, and are taken to an extreme ‘‘higher‐order’’ MCRs, where six or even more components react in a one‐pot, have been developed, although they remain scarce compared to their 3, 4 and 5‐component relatives. On this topic, the rich footprint of isocyanides in MCRs has been fruitful in delivering higher order six to eight‐component reactions through mechanistically similar pathways. The present review encompasses a brief history of MCRs and their product utility, followed by a thorough discussion of the principles of reaction design that enabled the discovery of higher‐order MCRs, spanning 6 to 8‐components. Future challenges and opportunities will also be elaborated.
Electrokinetic characterization of hybrid NOA 81‐glass microchips: Application to protein microchip electrophoresis with indirect fluorescence detection
Authors: Ben Frej Menel , d'Orlyé Fanny , Duarte‐Junior Gerson F. , Coltro Wendell K. T. , Varenne Anne 
Published: August 2022

AbstractA low‐cost and straightforward hybrid NOA (Norland optical adhesive) 81‐glass microchip electrophoresis device was designed and developed for protein separation using indirect fluorescence detection. This new microchip was first characterized in terms of surface charge density via electroosmotic mobility measurement and stability over time. A systematic determination of the electroosmotic mobility (μeo) over a wide pH range (2–10) and at various ionic strengths (20–50 mM) was developed for the first time via the neutral marker approach in an original simple frontal methodology. The evolution of μeo was proved consistent with the silanol and thiol functions arising from the glass and the NOA materials, respectively. The repeatability and reproducibility of the measurements on different microchips (RSD < 14%) and within 15 days (less than 5% decrease) were successfully demonstrated. The microchip was then applied for the efficient electrophoretic separation of proteins in a zonal mode coupled with indirect fluorescence detection, which is, to our knowledge, the first proof of concept of capillary zone electrophoresis in this hybrid microsystem.
Effect on DI‐CI naturally aspirated engine influenced by biodiesel blends doped with green synthesized silver nanofuel additive
Authors: Murugan Moorthi , Arthanarisamy Murugesan , Subbaiyan Rubavathi , Alagumalai Avinash 
Published: August 2022

AbstractThe objective of this study is to find the effect on DI‐CI naturally aspirated engine influenced by Manilkara Zapota biodiesel blends doped with green synthesized silver nanoparticles. The Manilkara Zapota biodiesel is used as base fuel and green synthesized silver nanoparticle as nanoadditive. The nanoparticle is prepared with the leaf extracts of Manilkara Zapota. The different test fuel blends are prepared with different concentrations of 40, 80, and 120 ppm of silver nanoparticles such as B100, B20, B20AgNP40ppm, B20AgNP80ppm, B20AgNP120ppm and diesel. The fuel properties are measured as per ASTM standard and compared the results with and without nanoparticles are presented in this paper. To validate the test fuel by conduct the experimental investigation on a single cylinder DI‐CI naturally aspirated engine loaded with eddy current dynamometer attached with combustion pressure transducer. The experimental results proved test fuel B20AgNP80ppm exhibits better results compared to other test fuels. The brake thermal efficiency of 33.31% was obtained for B20AgNP80ppm fuel which is 2.83% and 1.02% higher than B20 and diesel. The maximum reduction of CO obtained for the fuel blend B20 with addition of 80 ppm of AgNP were 33.33% and 37.5% compared to B20 and diesel. The UHC emission reduced by 32.6% and 38% for B20AgNP80ppm compared to B20 and diesel. It is also found that lower NOx and smoke for B20AgNP80ppm blend compared to B20 and diesel. The maximum cylinder pressure and heat release rate were achieved for B20AgNP80ppm compared to other blends.
A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force
Authors: van Vliet Erwin A. , Hildebrand Michael S. , Mills James D. , Brennan Gary P. , Eid Tore , Masino Susan A. , Whittemore Vicky , Bindila Laura , Wang Kevin K. , Patel Manisha , Perucca Piero , Reid Christopher A. 
Published: August 2022

AbstractThe International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy research‐related methods. Here, we have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for genomics, transcriptomics, and epigenomics in rodent models of epilepsy, with a specific focus on adult rats and mice. We discuss the important elements that need to be considered for genomics, transcriptomics, and epigenomics methodologies, providing a rationale for the parameters that should be collected. This is the first in a two‐part series of omics papers with the second installment to cover proteomics, lipidomics, and metabolomics in adult rodents.
Slip velocity boundary conditions for the lattice Boltzmann modeling of microchannel flows
Authors: Silva Goncalo , Ginzburg Irina 
Published: August 2022

AbstractSlip flows in ducts are important in numerous engineering applications, most notably in microchannel flows. Compared to the standard no‐slip Dirichlet condition, the case of slip formulates as a Robin‐type condition for the fluid tangential velocity. Such an increase in mathematical complexity is accompanied by a more challenging numerical transcription. The present work concerns with this topic, addressing the modeling of the slip velocity boundary condition in the lattice Boltzmann method (LBM) applied to steady slow viscous flows inside ducts of nontrivial shapes. As novelty, we extend the newly revised local second‐order boundary (LSOB) Dirichlet fluid flow method [Philos. Trans. R. Soc. A 378, 20190404 (2020)] to implement the slip velocity condition within the two‐relaxation‐time (TRT) framework. The LSOB follows an in‐node philosophy where its operation principle seeks to explicitly reconstruct the unknown boundary populations in the form of a third‐order accurate Chapman–Enskog expansion, where the wall slip condition is built‐in as a normal Taylor‐type condition. The key point of this approach is that the required first‐ and second‐order momentum derivatives, rather than computed through nonlocal finite difference approximations, are locally determined through a simple local linear algebra procedure, whose formulation is particularly aided by the TRT symmetry argument. To express the obtained derivatives, two approaches are considered, called and , which operate with node and wall variables, respectively. These two formulations are developed to prescribe the physical slip condition over plane and curved walls, including the corners. Their consistency and accuracy characteristics are examined against alternative linkwise strategies to impose the wall slip velocity, such as the kinetic‐based diffusive bounce‐back scheme, the central linear interpolation slip scheme, and the multireflection slip scheme. The several slip schemes are tested over different 3D microchannel configurations, with walls not conforming with the LBM uniform mesh. Numerical tests confirm the advanced accuracy characteristics of the proposed LSOB slip boundary scheme, revealing the added challenge of the wall slip modeling, and that parabolic accuracy is a necessary requirement to reach second‐order accuracy within this problem class.
Intrahepatic paracrine signaling by cardiotrophin‐like cytokine factor 1 ameliorates diet‐induced NASH in mice
Authors: Liu Tongyu , Wang Qiuyu , Zhou Linkang , Zhang Peng , Mi Lin , Qiu Xiaoxue , Chen Zhimin , Kuang Henry , Li Siming , Lin Jiandie D. 
Published: August 2022

Background and Aims:
The mammalian liver harbors heterogeneous cell types that communicate via local paracrine signaling. Recent studies have delineated the transcriptomic landscape of the liver in NASH that provides insights into liver cell heterogeneity, intercellular crosstalk, and disease‐associated reprogramming. However, the nature of intrahepatic signaling and its role in NASH progression remain obscure.

Approach and Results:
Here, we performed transcriptomic analyses and identified cardiotrophin‐like cytokine factor 1 (CLCF1), a member of the IL‐6 family cytokines, as a cholangiocyte‐derived paracrine factor that was elevated in the liver from diet‐induced NASH mice and patients with NASH. Adenovirus‐associated virus–mediated overexpression of CLCF1 in the liver ameliorated NASH pathologies in two diet‐induced NASH models in mice, illustrating that CLCF1 induction may serve an adaptive and protective role during NASH pathogenesis. Unexpectedly, messenger RNA and protein levels of leukemia inhibitory factor receptor (LIFR), a subunit of the receptor complex for CLCF1, were markedly downregulated in NASH liver. Hepatocyte‐specific inactivation of LIFR accelerated NASH progression in mice, supporting an important role of intrahepatic cytokine signaling in maintaining tissue homeostasis under metabolic stress conditions.

Conclusions:
Together, this study sheds light on the molecular nature of intrahepatic paracrine signaling during NASH pathogenesis and uncovers potential targets for therapeutic intervention.
Therapeutic management and outcome of patients with advanced systemic mastocytosis treated with midostaurin: A comprehensive real‐life study in the French national healthcare database
Authors: Rossignol Julien , Nizard Sandra , Blanc Anne‐Sandrine , Filipovics Anne , Lortet‐Tieulent Joannie , Bouktit Hassiba , Poinsot Gwendoline , Schmidt Aurélie , Raguideau Fanny , Hermine Olivier 
Published: August 2022

AbstractAdvanced Systemic Mastocytosis (Adv‐SM) is rare and has a poor prognosis. Midostaurin (Rydapt®) is one of the few treatments for Adv‐SM in Europe. The study aims were to describe the characteristics of patients treated with midostaurin, their treatment modalities, outcomes, and serious events requiring hospitalization. This retrospective observational study was conducted using the French National Healthcare Database (SNDS) and included adult Adv‐SM patients treated with midostaurin between 01‐01‐2012 and 09‐30‐2018. Kaplan‐Meier method was used to assess survival and treatment duration. Eighty‐one patients were included: 37 with Aggressive Systemic Mastocytosis (SM) (46%), 31 with SM with an Associated Hematological Neoplasm (38%), and 4 with Mast Cell Leukemia (5%). The SM subtype was undetermined in 9 patients (11%). The median age was 67 years; 64% of patients were male. Over the mean follow‐up of 11.4 months, median midostaurin treatment duration was 8.4 months and 28 patients (35%) were still under treatment at the end of the study. One‐year and 5‐year overall survival rates estimated since the time of diagnosis were 83% and 56%, respectively. Twelve serious events (among those frequently reported during clinical trials and compassionate use) requiring hospitalization were identified; a causal association with Adv‐SM treatment could neither be excluded nor established. In this first real‐life study on patients treated with midostaurin for Adv‐SM, the patients' characteristics, their management, treatment discontinuation, and survival were in line with previous results (compassionate use and clinical trials).
Harnessing the power of placebos and mitigating nocebo effects in clinical practice
Authors: Wettergreen Sara A. , Plauche Ardath K. , Stewart Morgan P. 
Published: August 2022

AbstractPlacebo and nocebo effects refer to the true or perceived benefits or harms, respectively, from either an inert or pharmacologically active substance. Both placebo and nocebo effects are often an unseen factor in the care of patients, yet remain controversial and underrecognized. As one of the most readily accessible health professionals, pharmacists are afforded myriad opportunities to address placebo and nocebo effects in their clinical practice settings. The balance between beliefs (positive effects) and fears (negative effects) is one that pharmacists can become adept at navigating through practical strategies provided for individuals, health‐systems, the pharmacy profession, and the overall healthcare community. Future research endeavors should focus on efficacy of previously discussed strategies when utilized by pharmacists, such as patient education strategies.
Theoretical investigation into the deciphering effects of atomic electronegativity on 2‐hydroxy‐phenyl‐tafamidis: A time‐dependent density functional theory study
Authors: Zhang Xiaoyu , Yuan Hengyi , Li Yi 
Published: August 2022

AbstractIn light of the potential probe applications of 2‐hydroxy‐phenyl‐tafamidis (2HPT) and its derivatives with different atomic electronegativity (2HPT‐O, 2HPT‐S, and 2HPT‐Se), the mechanisms of excited state intramolecular proton transfer (ESIPT) of 2HPT derivatives have been investigated in this work. Via probing into the geometric parameters of hydrogen bond O‐H···N, infrared vibrational spectroscopy, and bond critical point values, we can confirm that hydrogen bonding is enhanced in the first excited state (S1). It is worth mentioning that the enhancement of hydrogen bonding in the S1 state by low atomic electronegativity 2HPT‐Se is particularly important. In light‐induced excitation, by comparing the changed behaviors of highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) orbitals, it could be found that photo‐induced charge transfer happens in excited molecules, and charge redistribution facilitates ESIPT reaction. Particularly, the low atomic electronegativity could promote the ESIPT process for 2HPT system. In order to clarify the detailed ESIPT mechanism, we construct the potential energy curves, search for the transition state form, and determine the ESIPT mechanism for 2HPT fluorophores. In this work, we not only elucidated the excited state behavior of 2HPT systems but also proposed a novel mechanism for regulating ESIPT by atomic electronegativity.