bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHL1-deficient and wild-type male mice do not differ in locomotor recovery from spinal cord injury
Authors: Schachner Melitta , Theis Thomas , Ayala Carlos , Tschang Monica , Philip Michele , Nagaraj Vini , Shrirao Anil , Voronin Gregory 
Published: August 2022

Abstract
STUDY DESIGNAnimal studyOBJECTIVESFemale mice deficient in the adhesion molecule CHL1 recovered better than their wild-type female littermates after spinal cord injury (SCI). This observation was unexpected, because CHL1 increases neurite outgrowth in vitro in a homophilic, neuron-dependent manner. Yet, in SCI, CHL1 is upregulated in the glial scar which reduces axonal regrowth, showing that CHL1 on glia can block regrowth of CHL1 positive axons. This notion that was verified in co-cultures of astrocytes and neurons. Since these SCI experiments were confined to females in the previous study, we now sought to assess SCI in CHL1-deficient male mice.SETTINGSW.M. Keck Center for Collaborative Neuroscience at RutgersMETHODSMale CHL1-deficient and wild-type littermate mice received thoracic weight-drop SCI. Locomotor recovery was analyzed weekly by the Basso Mouse Scale and a single frame motion analysis up to six weeks after SCI, when lesion volumes were measured immunohistologically. Hematological analysis was performed at 24 hours after injury.RESULTSCHL1-deficient males did not recover better or worse than their male wild-type littermates. Primary and secondary lesion volumes were similar in the two genotypes under all conditions. In the peripheral blood at 24 h after SCI, leukocyte numbers in mutant males were slightly higher than in wild-type males, but monocyte and lymphocyte numbers did not differ between genders. Neutrophil numbers were higher in males than in females.CONCLUSIONThese results indicate that CHL1-deficient males and females differ in the number of neutrophils slightly in numbers of leukocytes, but not lymphocytes or monocytes.
A hybrid AHP-PROMETHEEII group decision support procedure with decision-makers’ weights assignment: Application in spatial localization
Authors: Omari Youcef , Hamdadou Djamila , Mami Mohammed Amine 
Published: August 2022

Abstract
Organizations and companies are getting increasingly enormous, comprising a significant number of managers and associates from all over the world. This globalization increases the complexity of decisions made within firms, as many decision-makers are engaged, each with their own view of the situation, and a variety of variables impact those judgments. The latter problem is referred to as Multicriteria Group Decision making (MGDM). Decision-makers in MGDM may have varying levels of power within the group; to express this authority, a weight should be assigned to each of them. Due to the impact of these weight values, this process of attributing weights must be held with care. In this paper the authors propose a strategy based on the PROMETHEE II method to handle MGDM problems; in the latter procedure, decision makers' weights are given objectively based on their contribution to the process. The main idea is to employ PROMETHEE II at three different levels: individual rating, weights attribution, and group ranking. The approach was put to the test on a real-world case study in territorial planning. This approach should be enhanced to take into account fuzzy and linguistic numbers, and it should be extended to additional application areas.
Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism
Authors: Park Sunghyouk , An Yong Jin , Jo Sihyang , Kim Jin-Mo , Kim Han Sun , Kim Hyun Young , Jeon Sang-Min , Han Dawool , Yook Jong In , Kang Keon Wook 
Published: August 2022

Abstract
Histone acetylation involves the transfer of a two-carbon unit to nucleus as embedded in low-concentration metabolites. We find that lactate, a high-concentration metabolic by-product, can be a major carbon source for histone acetylation, through oxidation-dependent metabolism. Both in cells and in purified nucleus, 13C3-lactate carbons are incorporated into histone H4 (maximum incorporation: ~60%). In purified nucleus, this process depends on nucleus-localized lactate dehydrogenase (LDHA), the knockout of which abrogates the incorporation. Heterologous expression of nucleus-localized LDHA rescues the KO effect. Lactate itself increases histone acetylation, whereas inhibition of LDHA reduces the acetylation. In vitro and in vivo settings exhibit different lactate incorporation patterns, suggesting an influence of the microenvironment. Higher nuclear LDHA localization is observed in pancreatic cancer than in normal tissues, showing the disease relevance. Overall, lactate and nuclear LDHA can be major structural and regulatory players in the metabolism-epigenetics axis controlled by cell’s own or environmental status.
Erosion Source Area Identification Using Rusle and Multi-criteria Decision Analysis, Acase of Andassa Watershed, Upper Blue Nile Basin
Authors: Tegegne Moges Animut , Zewudu Yibeltal , Fentahun Tadele 
Published: August 2022

Abstract
The Main objective of this study was to identify source areas of soil erosion and quantify rate of soil erosion and sediment yield in Andassa watershed, Blue Nile Basin. In this study, Multi Criteria Decision analysis (MCDA) technique integrated with GIS and Remote sensing was applied to estimate soil erosion source areas, identify major soil erosion factor (s), prioritize and map the most sensitive soil erosion sources of the watershed for soil and water conservation practice. From soil erosion factors, Topographic wetness index followed by land use land cover have been found to have significant effect on soil erosion in the watershed. The result shows in qualitative Sensitivity map investigates that the more than half of the watershed was under moderately sensitive risk of soil erosion (68.12%) about 400.861km2. Next 17.56% (103.35km2) of the watershed was under slightly sensitive and the remaining 14.27% (83.999 km2) of the watershed was under highly sensitive risk of soil erosions. From the overall combined map of Multicriteria decision analysis (MCDA) map showing the areas of increased risk erosion represented by highly sensitive (S1), moderately sensitive(S2), less sensitive(S3), and constraint areas so the governmental or non-governmental organizations or any concerned organization should refer this important severity map of soil erosion for watershed management and priority of the watershed. Even though measured values of sediment yield at the catchment are hardly available the hotspot areas can be identified by multicriteria decision analysis and significant amount of soil loses are sourced from Gully sites.
Association of FGF10 polymorphism of rs339501 with myopia: A systematic review and meta-analysis
Authors: Hou Peixian , Yang Guoyuan , Chen Pengfan , Wang Guiqu , Liu Longqian 
Published: August 2022

Abstract
Purpose: To carry out a meta-analysis of potential genetic association studies in order to determine whether the FGF10 polymorphism rs339501 is related to myopia. Method: All the eligible case control studies examing the association of FGF10 polymorphisms and myopia published up to 20 January 2022 were retrieved from MEDLINE, Embase, the Cochrane library, Web of Science, the China National Knowledge Infrastructure (CNKI) and the VIP database of Chinese periodicals without language restriction. Depending on the heterogeneity among studies, a fixed-effect model or a random-effect model was chosen to compute the 95% confidence intervals (95%CIs) and odds ratios (ORs) for single nucleotide polymorphism (SNP). Publication bias were analyzed by examining the symmetry of the funnel plots and further confirmed by Begg’s and Egger’s tests. Stability of the analyses was checked by the sensitivity analysis.Results：6 studies were finally included in our analysis. The subgroup analyses focusing on Chinese population found some significant results, which mainly fell on the recessive model and homozygote model(p<0.05), especially for the high myopia, of whom the pooled results in allelic model and dominant model(p＜0.05) were also significant. Additionally, the allelic model(p＜0.05) for the correlation between SNP rs339501 and myopia was also significant in Chinese population. Unfortunately, our analysis for the overall population did not reach a statistically significant result.Conclusion: G allele of SNP rs339501 would increase the risk of myopia for Chinese population. Large-scale researches are still needed to corroborate the associations.
Conjugated polymer-functionalized perovskite semiconductors for electrolyte-gated transistors
Authors: Nketia-Yawson Vivian , Nketia-Yawson Benjamin , Opoku Henry , Lee Ji Hyeon , Jo Jea Woong 
Published: August 2022

Abstract
In emerging perovskite transistors, interfacial engineering is pivotal for modulating the effective charge carrier transport; however, gate dielectric layer and its interface remain unexplored owing to the limited chemical stability of perovskites. Here, we propose an interfacial functionalization with a conjugated polymer to allow the use of high capacitance electrolyte dielectric in top-gate perovskite transistors. This multifunctional approach, exploiting orthogonal solution-processed polymers, enables blocking of chemical diffusion during the deposition of the dielectric, allows passivation of defects on the perovskite surface, results in air stability enhancement, and boosts mobility via the formation perovskite-polymer hybrid channels. The optimized conjugated polymer-capped lead iodide perovskite transistors showed a remarkable hole mobility of over 30 cm2 V–1 s–1 at ≤ 2 V. This result demonstrated the possibility of realizing high mobility through interfacial functionalization of perovskites in transistor applications.
Fine Particulate Matter Exposure and Inhalation Dose during Traffic Commuting-A Case Study in Guangzhou
Authors: Li Zhisheng , Zeng Jiangyi , Wu Mengting , Jin Yukai , Wang Xiaoxia , Zhai Shuya 
Published: August 2022

Abstract
This research focuses on the PM exposure of commuters under five modes of transportation (subway, bus, bicycle, automobile and walking) in Haizhu District, Guangzhou. By portable aerosol Monitor (Grimm spectrometer, Model 11-R) with a time resolution of 6 seconds, the real-time exposure concentration, the average exposure concentration and inhalation dose of commuters were analyzed. The length of route is designed as a 60-minute walking distance, about 4 kilometers. The average PM2.5 exposure concentration of different commuting modes was 29.77 ± 6.33µg/m³, 22.98 ± 3.13µg/m³, 35.50 ± 7.14µg/m³, 28.65 ± 4.12µg/m³, 10.75 ± 1.04µg/m³ and 47.29 ± 14.24µg/m³, corresponding to subway, bus, bicycle, car(windows closed), car(windows open) and walking respectively. During peak hours, commuters who take subway, bus and car can better avoid exposure to particulate pollution, especially in the evening rush hour. The opening or closing of the window is a critical factor affecting the exposure concentration of pollutants in the car. The inhalation dose of PM2.5 was 1.057 ± 0.003µg, 1.654 ± 0.002µg, 21.088 ± 0.021µg, 1.722 ± 0.003µg, 0.601 ± 0.001µg, and 31.723 ± 0.018µg, corresponding to subway, bus, bicycle, car(windows closed), car(windows open) and walking. According to the research, sub-micron particles (PM1.0) are the main particles in subway and the opening, and in the compartment, closing of compartment doors causes an instantaneous spike in the concentration of particulate matter .
Comparison of Fetal Heart Rate Baseline Estimation by the Cardiotocograph Network and Clinicians: A Multidatabase Retrospective Assessment Study
Authors: Pan Xiuyu , Lu Yaosheng , Zhong Mei , Wang Huijin , Zheng Zheng , Bai Jieyun 
Published: August 2022

Abstract
Objective
This study aims to compare the fetal heart rate (FHR) baseline predicted by the cardiotocograph network (CTGNet) with that estimated by clinicians.
Results
A total of 1267 FHR recordings acquired with different electrical fetal monitors (EFM) were collected from five datasets. Each FHR baseline was estimated by clinicians and CTGNet, respectively. And agreement between CTGNet and clinicians was evaluated using the kappa statistics, intra-class correlation coefficient, and the limits of agreement. The number of differences < 3 beats per minute (bpm), 3–5 bpm, 5–10 bpm and ≥ 10 bpm, is 64.88%, 15.94%, 14.44% and 4.74%, respectively. Kappa statistics and intra-class correlation coefficient are 0.873 and 0.969, respectively. Limits of agreement are − 6.81 and 7.48 (mean difference: 0.36 and standard deviation: 3.64). An excellent agreement was found between CTGNet and clinicians in the baseline estimation from FHR recordings with different signal loss rates.
Relationship between glycemic variability and arrhythmias: protocol for a systematic review and meta-analysis
Authors: Li zinan , Yang Jiao , Qiu Xianliang , Zhou Qian , Fu Shunlian , Chen Qiu 
Published: August 2022

Abstract
Introduction
Arrhythmias are common in type 2 diabetic patients. The link between blood glucose fluctuations and arrhythmia risk is gaining attention.TThe aim of this systematic review is to investigate the relationship between blood glucose variability and arrhythmia in patients with T2DM and provide more advanced evidence for clinical practice.
Methods and analysis
PubMed, EMBASE, The Cochrane Library, China Biology Medicine disc, and the Wanfang database online will be included to be searched.We'll look for publications, conference papers, current trials, and internal reports, as well as observational research, by hand (cross-sectional and follow-up studies) written in English or Chinese examining the relationship between abnormal glycemic variability and arrhythmias in patients with T2DM up to 30 June 2021.The articles will be read independently by two reviewers. Information such as first author, time of publication and outcome measures will be extracted. Researchers will also assess the quality of the literature using the Cochrane Handbook's quality assessment criteria. RevMan 5.3.5, EndNote X7, and STATA 13.0 will be utilized for data analysis.We will use extractable data for systematic evaluation at last.
Ethics and dissemination:
Because this systematic review used published data, no ethical approval was necessary.
Physics of sliding on water predicts morphological and behavioral allometry in water striders
Authors: Kim Woojoo , Lee Jae Hong , Pham Thai , Tran Anh , Ha Jungmoon , Bang Sang Yun , Jablonski Piotr , Kim Ho-Young , Lee Sang-im 
Published: August 2022

Abstract
Water striders, Gerridae, serve as model organisms to understand locomotion on the water surface, but only a narrow range of body sizes have been studied. The hydrodynamics of their thrust is well understood, but the subsequent sliding dynamics has been less explored. Here we create a theoretical model of sliding and use it to predict the effect of body mass, striding gait (symmetrical or asymmetrical) and wetted leg lengths on the striders’ ability to float and the resistance during sliding. We show that the water strider species with large body size have two alternative solutions: development of long forelegs that support frontal body during symmetrical striding or asymmetrical striding when one midleg extends forward to support the frontal body. The model lays the theoretical grounds for the future comparative analyses of adaptive allometry in locomotion of Gerridae, and for bioinspired water walking devices of a wide size range.
Expression of Satb2 in adult brain of key non-mammalian vertebrates: insights from evolution
Authors: Lozano Daniel , López Jesús M. , Morona Ruth , Jiménez Sara , Moreno Nerea 
Published: August 2022

Abstract
Satb2 is a transcription factor with functional and regulatory mechanisms, and post-translational modifications highly conserved in mammals. However, although its distribution has been analyzed in the mouse brain, there are few data in other non-mammal models. Therefore, in the present study we have analyzed the immunolocalization of Satb2 in the brain of adult specimens of different models at key evolutionary points of vertebrate diversification, including representative species of sarcopterygians and actinopterygians. In addition, we used other neuronal markers of highly conserved populations in the vertebrate brain, such as catecholaminergic, serotonergic and Otp populations, involved in the specificity of certain brain areas. The neuroanatomical pattern of Satb2, interpreted according to the current prosomeric model, serves to identify brain regions and compare them among the studied species, and with previous reported data, mainly for amniotes. We identified that Satb2 expressions have similar topologies in the subpallium of models studied, whereas striking differences were found in the pallium between sarcopterygian and actinopterygian vertebrates. Only the turtle showed expression in the dorsal derivatives of the pallium, specifically in the dorsal cortex, only scattered in Xenopus, whereas the lateral derivatives of the pallium expressed Satb2 in sarcopterygians, but not in actinopterygians. In the medial amygdala, or homologous structures, all models expressed Satb2, but only tetrapods also co-expressed Otp, probably originating from the paraventricular hypothalamic region, since only in those models a minor population of Satb2/Otp cells was also detected. In the caudal telencephalon, all models showed significant expression in the preoptic area, including the acroterminal domain of this region, where Satb2-expressing cells were dopaminergic. In the alar hypothalamus, all models showed Satb2 in the subparaventricular area, whereas in the basal hypothalamus only sarcopterygians showed a significant population in the tuberal hypothalamus, doubly labeled with Otp only in lungfish. The diencephalon of sarcopterygians showed Satb2 labeling in the prethalamus, and only turtles and lungfish showed expression in the thalamus. At midbrain levels, the optic tectum housed scattered Satb2 cells exclusively in turtles, while the expression along the rostrocaudal reticular formation and parabrachial nucleus was a conserved feature of sarcopterygians. The neuroanatomical pattern of Satb2 revealed important differences between sarcopterygians and actinopterygians, and these divergences may be related to the distinct functional involvement of Satb2 in the acquisition of various neural phenotypes and in the establishment of connectivity of these cells.
Cost-effective screen-printed carbon electrode biosensors for rapid detection of Microcystin-LR in surface waters for early warning of harmful algal blooms
Authors: Stoll Stephanie , Hwang Jae-Hoon , Fox David W. , Kim Keugtae , Zhai Lei , Lee Woo Hyoung 
Published: August 2022

Abstract
Abstract
Microcystins (MCs) are toxins produced by cyanobacteria commonly found in harmful algal blooms (HABs). Due to their toxicity to humans and other organisms, the World Health Organization (WHO) set a guideline of 1 µg L− 1 for microcystin-leucine-arginine (MC-LR) in drinking water. However, current analytical techniques for the detection of MC-LR such as liquid chromatography-mass spectrometry (LC-MS) and ELISA are costly, bulky, time-consuming, and mostly conducted in a laboratory, requiring highly trained personnel. An analytical method that can be used in the field for rapid determination is essential. In this study, an Anti-MC-LR/MC-LR/Cysteamine coated screen-printed carbon electrode (SPCE) biosensor was newly developed to detect MC-LR, bioelectrochemically, in water. The functionalization of the electrode surface was confirmed with surface characterization methods. The sensor performance was evaluated by electrochemical impedance spectroscopy (EIS), obtaining a linear working range of MC-LR concentrations between 0.1 and 100 µg L− 1 with a limit of detection (LOD) of 0.69 ng L− 1. Natural water samples experiencing HABs were collected and analyzed using the developed biosensor, demonstrating the excellent performance of the biosensor with a relative standard deviation (RSD) of 0.65%. The interference tests showed a minimal error and RSD values against other common MCs and possible coexisting ions found in water. The biosensor showed acceptable functionality with a shelf life of up to 12 weeks. Overall, the Anti-MC-LR/MC-LR/Cysteamine/SPCE biosensors can be an innovative solution with characteristics that allow for in situ, low-cost, and easy-to-use capabilities which are essential for developing an overarching and integrated “smart” environmental management system.
Genome-wide investigation and analysis of growth-regulating factor family in pineapple (Ananas comosus var. comosus)
Authors: yi wen , He Yehua , Qiu Mengqing , Chen Chengjie , Wu Jing 
Published: August 2022

Abstract
Background: growth-regulating factors（GRFs）are plant-specific transcription factors that play an important role in plant growth and development, Although the GRF gene family has been identified in many species, a genome-wide analysis of this gene family in pineapple has not been reported.Results: In this study, 8 pineapple GRF genes (AcGRF) were identified and renamed according to their chromosomal locations.8 AcGRFs were divided into three main families and subgroups based on their structural and phylogenetic characteristics. Genomic collinearity analysis found that segmental duplication played a more important role in the expansion of the pineapple GRF gene family. GRF gene collinearity analysis and phylogenetic analysis provide deeper insights into the evolutionary characteristics of pineapple GRF genes. Transcriptome data and real-time quantitative PCR analysis revealed AcGRF gene expression patterns in various tissues and responses to different abiotic stresses and hormonal treatments.Conclusions: In this study, 8 GRF genes were identified in pineapple, and their coding gene structures, evolutionary characteristics, and expression patterns were analyzed. This systematic analysis provides a basis for further identification of pineapple GRF gene function.
Factors affecting gastrointestinal function after cesarean section among Chinese mothers: A cross-sectional study
Authors: Liu Yi , Xiang Jie , Ren Jianhua , Gu Li , Wang Yu , Liu Xiuping , Wen Jiao 
Published: August 2022

Abstract
Aim
This study was conducted to learn about the influencing factors of gastrointestinal function after cesarean section (C-section), which could provide a reference for the Enhanced Recovery after Surgery (ERAS) in Obstetrics.
Methods
This is a cross-sectional survey on Chinese mothers receiving C-section. The participants’s socio-demographic characteristics, perioperative diet, medical condition and gastrointestinal function after surgery were collected by a self-designed questionnaire. Binary logistic regression analysis was employed to explore the influencing factors of gastrointestinal function after C-section.
Results
A total of 1501 (94.76%) valid questionnaires were collected. The first borborygmus was 2.21 ± 0.63 hours, and the first anal exhaust was 35.73 ± 14.85 hours after the C-section. The incidence of abdominal distension and intestinal obstruction were 15.1% and 0.7%, respectively. The two-hours bleeding after surgery, time of first meal after surgery, whether performing sacrococcygeal physical therapy and taking peppermint water after surgery were the independent protective factors for gastrointestinal function recovery after C-section.
Conclusion
The new mothers with C-section should be encouraged to eat early, perform sacrococcygeal physical therapy and take peppermint water to promote intestinal peristalsis actively.