bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of an APOBEC3 deletion polymorphism for glioma patients in Taiwan
Authors: Chen Chia-Hua , Wei Kuo-Chen , Liao Wei-Chao , Lin You-Yu , Chen Hsiu-Chi , Feng Li-Ying , Liu Chiung-Hui , Huang Chiung-Yin , Chen Ko-Ting , Wu Chi-Sheng , Chang Yu-Sun , Yu Jau-Song , Chang Ian Yi-Feng 
Published: October 2022

OBJECTIVE
The molecular pathogenesis of malignant gliomas, characterized by diverse tumor histology with differential prognosis, remains largely unelucidated. An APOBEC3 deletion polymorphism, with a deletion in APOBEC3B, has been correlated to risk and prognosis in several cancers, but its role in glioma is unclear. The authors aimed to examine the clinical relevance of the APOBEC3 deletion polymorphism to glioma risk and survival in a glioma patient cohort in Taiwan.

METHODS
The authors detected deletion genotypes in 403 glioma patients and 1365 healthy individuals in Taiwan and correlated the genotypes with glioma risk, clinicopathological factors, patient survival, and patient sex. APOBEC3 gene family expression was measured and correlated to the germline deletion. A nomogram model was constructed to predict patient survival in glioma.

RESULTS
The proportion of APOBEC3B−/− and APOBEC3B+/− genotypes was higher in glioblastoma (GBM) patients than healthy individuals and correlated with higher GBM risk in males. A higher percentage of cases with APOBEC3B− was observed in male than female glioma patients. The presence of APOBEC3B−/− was correlated with better overall survival (OS) in male astrocytic glioma patients. No significant correlation of the genotypes to glioma risk and survival was observed in the female patient cohort. Lower APOBEC3B expression was observed in astrocytic glioma patients with APOBEC3B−/− and was positively correlated with better OS. A 5-factor nomogram model was constructed based on male patients with astrocytic gliomas in the study cohort and worked efficiently for predicting patient OS.

CONCLUSIONS
The germline APOBEC3 deletion was associated with increased GBM risk and better OS in astrocytic glioma patients in the Taiwan male population. The APOBEC3B deletion homozygote was a potential independent prognostic factor predicting better survival in male astrocytic glioma patients.
Factors associated with radiation toxicity and long-term tumor control more than 10 years after Gamma Knife surgery for non–skull base, nonperioptic benign supratentorial meningiomas
Authors: Lee Eun Jung , Chung Hyun-Tai , Park Hangeul , Kim Jin-Wook , Kim Dong Gyu , Paek Sun Ha 
Published: October 2022

OBJECTIVE
Gamma Knife surgery (GKS) is a well-established treatment for benign intracranial meningiomas; however, the dosimetric factors associated with long-term GKS efficacy and safety remain to be elucidated. Using data obtained with at least 10 years of follow-up, the authors aimed 1) to analyze GKS efficacy and safety for the treatment of benign meningiomas confined to non–skull base, nonperioptic supratentorial locations and 2) to determine the radiation dose window that allows for long-term efficacy and safety, namely the minimum dose to achieve long-term local control (LC) and the maximum safe dose to avoid adverse radiation effects (AREs).

METHODS
A retrospective analysis was performed on patients who underwent GKS for benign meningiomas in the abovementioned location at the authors’ institution between 1998 and 2010 and who received follow-up for more than 10 years. The authors meticulously extracted the values of various dosimetric factors by using a dose-volume histogram. Cox proportional hazard regression analyses were performed to investigate the dosimetric factors associated with LC and ARE.

RESULTS
Fifty-five patients (male/female ratio 1:4.2) with 68 tumors were enrolled. The median (range) gross target volume and marginal dose were 4.2 (0.2–31.7) cm3 and 14.3 (9–20) Gy, respectively. In total, 23.5% of tumors progressed at an average of 72 months, with 10- and 15-year progression-free survival rates of 80.9% and 73.5%, respectively. In univariate analysis, higher marginal dose, coverage (%), Dmin, D98%, Dmean, D2%, Dmax, and Paddick conformity index were significantly associated with LC. In multivariate analysis, D98% was the significant factor, with a cutoff value of 11 Gy (HR 0.754, p < 0.001). Symptomatic AREs occurred in 7 patients at an average of 7 months after GKS. AREs were significantly associated with the volume of normal tissue irradiated with more than 14 Gy (nV14Gy), with a cutoff value of 0.66 cm3 (HR 2.459, p = 0.002).

CONCLUSIONS
D98% was a barometer of the minimum required dose associated with long-term LC, and nV14Gy was related to symptomatic AREs. The authors recommend a marginal dose ranging from 11 to 14 Gy to achieve long-term efficacy and safety in patients with non–skull base, nonperioptic benign supratentorial meningiomas, with the assumption of thorough tumor coverage.
Fortalecimiento de los saberes disciplinares de Ciencias Naturales en la Institución Educativa Jorge Eliecer Gaitán del municipio de Orito, Putumayo
Authors: Muñoz Erazo Richard Edgardo , Suarez Buchelly Emerson Arturo 
Published: October 2022

El presente trabajo surgió del problema encontrado en los estudiantes de grado sexto de la Institución Educativa Jorge Eliecer Gaitán del municipio de Orito, Putumayo, para asimilar los saberes disciplinares de peso, masa, volumen y densidad, en ausencia de un aula especializada de ciencias naturales.
Para muchos de ellos, el área de ciencias naturales resulta aburrida e irrelevante debido a la metodología con la que los docentes imparten sus clases quienes, debido a la poca o nula disponibilidad de equipos o herramientas, se ven limitados a la fundamentación teórica, sin recursos que permitan más actividad en la clase. Los estudiantes de grado sexto presentan dificultades para asimilar conceptos sobre peso, masa, volumen y densidad, reflejado negativamente en las temáticas correspondientes a los grados posteriores de básica secundaria y educación media; además, no existe una sistematización de experiencias significativas en la institución para la enseñanza de los procesos físicos de las ciencias naturales; por lo tanto, el objetivo general giró en torno a fortalecer estos saberes conceptuales, a través del aprendizaje basado en proyectos de ciencias naturales.
Los objetivos específicos fueron: Identificar, a través de una prueba diagnóstica, los conceptos que manejan los estudiantes de grado sexto, describir las prácticas pedagógicas que implementan los docentes de ciencias naturales para la enseñanza de estos conceptos, diseñar e efectuar una estrategia metodológica física para fortalecerlos, como alternativa a la ausencia del laboratorio en la institución y, evaluar la implementación de la estrategia metodológica para analizar el impacto en los estudiantes. La pregunta problema se planteó así: ¿Las prácticas de laboratorio con materiales de la vida cotidiana permiten fortalecer los saberes conceptuales de peso, masa, volumen y densidad en estudiantes de grado sexto?, datos con los cuales se desarrolló la investigación.
Do a Visual Presentation
Authors: Ellison Stacey 
Published: October 2022

A visual presentation, either a demonstration or an illustrated talk, is a teaching method in which the presenter shares information with an audience with the assistance of visual aids such as posters, models, and computer presentation software. This 4-page fact sheet covers the method of delivery, the plan, the visuals, how to look sharp and to have a sharp presentation. Written by Stacey Ellison, and published by the UF Department of 4-H Youth Development, June 2015.
4HGCO59/4H163: Do a Visual Presentation (ufl.edu)
Plant Connections Leader's Guide
Authors: Easton Janice , Glauer Deborah J. 
Published: October 2022

This revised 195-page curriculum guide is aimed at educating youth about the basics of horticulture. Youth will be exposed to information on plants and the plant kingdom. Written by Janice Easton and Deborah J. Glauer, and published by the UF Department of 4-H Youth Development, January 2015.
4HPSL21/4H192: Plant Connections Leader's Guide (ufl.edu)
Individual Chapters:

4H357/4H357: Plant Connections Leader's Guide—Introduction
4H358/4H358: Plant Connections Leader's Guide—Lesson 1: What Is a Plant?
4H359/4H359: Plant Connections Leader's Guide—Lesson 2: Why Are Plants Important?
4H360/4H360: Plant Connections Leader's Guide—Lesson 3: What Makes Plants Grow?
4H361/4H361: Plant Connections Leader's Guide—Lesson 4: How to Grow Plants
4H362/4H362: Plant Connections Leader's Guide—Lesson 5: How to Select and Handle Plants
4H363/4H363: Plant Connections Leader's Guide—Lesson 6: The Future in Plants
Guide to the Florida 4-H Council
Authors: Ellison Stacey E. , Tesdall Tracy , Rutledge J. A. , Jordan Joy C. , Armstrong Wendi 
Published: October 2022

The 4-H Program utilizes many tools or methods to provide educational experiences for youth. The 4-H Council (or other relevant named groups) at county, district, and state levels is one of these tools. A Council is an elected representative group of 4-H members who meet, discuss, plan, and assist in carrying out 4-H programs and activities in the interest of the total membership. The Council provides a link between local clubs or groups and County 4-H Programs, between County Programs and District 4-H Programs, and between District Programs and State 4-H Programs. This revised 11-page guide was written by Stacey E. Ellison, Tracy Tesdall, J. A. Rutledge, Joy C. Jordan, and Wendi Armstrong, and published by the UF Department of 4-H Youth Development, October 2014.
4H GCM 12/4H315: A Guide to the Florida 4-H Council (ufl.edu)
Plant Connections Leader's Guide—Introduction
Authors: Easton Janice , Glauer Deborah J. 
Published: October 2022

This revised document is the introduction to the Kids Growing with Plant Connections Leader’s Guide. It is part of the 4-H Plant Connections Curriculum, which is aimed at educating youth about the basics of horticulture. In this guide, youth will be exposed to information on plants and the plant kingdom. Written by Janice Easton and Deborah J. Glauer, and published by the UF Department of 4-H Youth Development, January 2015.
4H357/4H357: Plant Connections Leader's Guide—Introduction (ufl.edu)
Plant Connections Leader’s Guide—Lesson 1: What Is a Plant?
Authors: Easton Janice , Glauer Deborah J. 
Published: October 2022

This revised document is the first lesson of the Kids Growing with Plant Connections Leader’s Guide. It is part of the 4-H Plant Connections Curriculum, which is aimed at educating youth about the basics of horticulture. In this guide, youth will be exposed to information on plants and the plant kingdom. Written by Janice Easton and Deborah J. Glauer, and published by the UF Department of 4-H Youth Development, January 2015.
4H358/4H358: Plant Connections Leader's Guide—Lesson 1: What Is a Plant? (ufl.edu)
Plant Connections Leader’s Guide—Lesson 4: How to Grow Plants
Authors: Easton Janice , Glauer Deborah J. 
Published: October 2022

This revised document is the fourth lesson of the Kids Growing with Plant Connections Leader’s Guide. It is part of the 4-H Plant Connections Curriculum, which is aimed at educating youth about the basics of horticulture. In this guide, youth will be exposed to information on plants and the plant kingdom. Written by Janice Easton and Deborah J. Glauer, and published by the UF Department of 4-H Youth Development, January 2015.
4H361/4H361: Plant Connections Leader's Guide—Lesson 4: How to Grow Plants (ufl.edu)
Best Management Practices for Siting Honey Bee Colonies: Good Neighbor Guidelines
Authors: Ellis James D. , Hayes Jerry 
Published: October 2022

Keeping honey bees requires responsible management so that the bees do not become a nuisance. Additionally, the presence of Africanized honey bees in Florida places more pressure on beekeepers to maintain their colonies properly. This revised 3-page fact sheet is a reference for honey bee management in Florida, with emphasis on siting apiaries in sensitive locations, in order to promote harmonious cooperation between beekeepers, neighbors, and landowners. Written by Jamie Ellis and Jerry Hayes, and published by the UF Department of Entomology and Nematology, November 2014. (Photo by Thien Gretchen (CC BY-NC-ND 2.0), via Flickr)
ENY115/AA137: Best Management Practices for Siting Honey Bee Colonies: Good Neighbor Guidelines (ufl.edu)
How Do I Legally Sell Meat from My Own Livestock and Poultry in the State of Florida?
Authors: Carr Chad , Scheffler Jason , Eubanks Larry , Webb Ron , Cornman Lee , Talley Scotland , Stiegler Steve 
Published: October 2022

There is much interest in locally produced foods, but the federal, state, and local regulations can be confusing. This 5-page fact sheet is a “one-stop-shop” for Florida residents who want to sell meat from their own livestock and poultry. Written by Chad Carr, Jason Scheffler, Larry Eubanks, Ron Webb, Lee Cornman, Scotland Talley, and Steve Stiegler, and published by the UF Department of Animal Sciences, December 2014. (Photo: iStock/Thinkstock.com)
AN316/AN316: 2021—How Do I Legally Sell Meat from My Own Livestock and Poultry in Florida? (ufl.edu)
Not All Landscape Palm Fertilizers Are Created Equal
Authors: Broschat Timothy K. 
Published: October 2022

Palms are widely planted in Florida landscapes. Their bold leaf textures create a tropical or Mediterranean look that is highly desired by residents and tourists alike. But palms have very high nutritional requirements, and deficiencies of any element can result in conspicuous and unattractive symptoms on their large leaves. UF/IFAS research shows that the most effective fertilizer has 100% of the N, K, Mg, and B sources in slow-release or controlled-release form and that all of the Mn, Fe, Zn, and Cu sources should be water soluble. This 4-page fact sheet explains the reasons for this recommendation and how to ensure that you have a formulation that will be effective. Written by Timothy K. Broschat, and published by the UF Department of Environmental Horticulture, April 2015. (Photo Credit: T.K. Broschat)
ENH1255/EP516: Not All Landscape Palm Fertilizers Are Created Equal (ufl.edu)
Economic Impacts of Highway Beautification in Florida
Authors: Khachatryan Hayk , Hodges Alan W. , Rahmani Mohammad , Stevens Thomas J. 
Published: October 2022

The Florida Department of Transportation is allocated money every year for highway landscaping projects. They make driving more pleasant and are better for the environment, but do they attract private investment and contribute to the economy? This study, commissioned by the FDOT, finds that the average annual economic impacts of highway beautification expenditures in Florida during 2008–2013 amounted to $46 million in output impacts and $28 million in value-added impacts. This 7-page fact sheet was written by Hayk Khachatryan, Alan W. Hodges, Mohammad Rahmani, and Thomas J. Stevens, and published by the UF Department of Food and Resource Economics, December 2014. http://edis.ifas.ufl.edu/fe963
How to Start a Food Business: Writing a Business Plan
Authors: Ahn Soohyoun , House Lisa , Goodrich-Schneider Renée 
Published: October 2022

Before starting a new food business, you should set a goal and have detailed plans to accomplish that goal. But writing a good business plan is often a challenge and it requires a great amount of effort. This 4-page fact sheet provides guidance on how to write a good food-business plan. Written by Soohyoun Ahn, Lisa House, and Renée Goodrich-Schneider, and published by the UF Department of Food Science and Human Nutrition, December 2014. (Photo: iStock/Thinkstock)
FSHN14-12/FS259: How to Start a Food Business: Writing a Business Plan (ufl.edu)
Women's Nutrition: Folate/Folic Acid
Authors: Dunn Caroline , Kauwell Gail 
Published: October 2022

To decrease a baby’s chances of having certain types of births defects, mothers need to have already been consuming enough of the vitamin called folate, or folic acid, before they become pregnant. This article provides information about the folate/folic acid needs of women who are capable of becoming pregnant, including its role in preventing birth defects, sources, and strategies for meeting the recommended intake. This 4-page fact sheet was written by Caroline Dunn and Gail Kauwell, and published by the UF Department of Food Science and Human Nutrition, February 2015. (Photo Credit: Mike Watson Images/moodboard/Thinkstock.com)
FSHN15-03/FS265: Women's Nutrition: Folate/Folic Acid (ufl.edu)
Seguridad Alimentaria: ¿Su cocina pasa la prueba?
Authors: Hillan Jennifer , Bobroff Linda B. 
Published: October 2022

Los adultos mayores corren un riesgo mayor de contraer enfermedades por alimentos. Para ayudar a reducir el riesgo, es importante tener prácticas de manipulación de alimentos sanas. ¿Cómo se mide su cocina?
This revised 2-page fact sheet is the Spanish-language version of FCS8801/FY926: Food Safety: Does Your Kitchen Pass the Test? Written by Jennifer Hillan and Linda B. Bobroff, and published by the UF Department of Family, Youth and Community Sciences, December 2014.
Breast Cancer: Making Sense of the Numbers
Authors: Monroe Martha C. , Shea Barbara F. , Bobroff Linda B. 
Published: October 2022

A breast cancer diagnosis is always a challenge to the patient and her family.* People react in different ways to a breast cancer diagnosis. Some breast cancer patients want to take an active role in understanding and choosing their treatment, and others prefer to leave decisions to their health care providers. This revised 5-page fact sheet, first in a 12-part series on breast cancer, provides information that will help persons who want to understand and be actively involved in treatment decisions. Written by Martha C. Monroe, Barbara F. Shea, and Linda Bobroff, and published by the UF Department of Family, Youth and Community Sciences, December 2014. (Photo: iStock/Thinkstock)
FCS8825/FY895: Breast Cancer: Making Sense of the Numbers (ufl.edu)
Pest Identification Guide: Two-spotted Spider Mite, Tetranychus urticae Koch
Authors: Casuso Nicole , Smith Hugh 
Published: October 2022

This publication is part of the Pest Identification Guide series, created to help growers and crop consultants, private homeowners, Master Gardeners, and the general public identify common arthropod pests and the damage they inflict. Each field guide provides photos of the important life stages and crop damage associated with arthropod pests. The text highlights key general morphology and biology, distribution, and natural enemies. Written by Nicole Casuso and Hugh Smith, and published by the UF Department of Entomology and Nematology, October 2014.
ENY-880/IN1059: Pest Identification Guide: Two-spotted Spider Mite, Tetranychus urticae Koch (ufl.edu)
Wedge-Shaped Beetles (suggested common name) Ripiphorus spp. (Insecta: Coleoptera: Ripiphoridae)
Authors: Owens David , Mortensen Ashley N. , Klopchin Jeanette , Kern William , Ellis Jamie D. 
Published: October 2022

Ripiphoridae are a family of unusual parasitic beetles that are thought to be related to tumbling flower beetles and blister beetles. They parasitize bees and wasps, roaches, and wood-boring beetles, but specific hosts for many ripiphorid species are unknown. Their secretive life cycle makes an assessment of their economic and ecological impact very difficult. Additional research is necessary to determine the abundance and impact of Ripiphorus species. This 4-page fact sheet was written by David Owens, Ashley N. Mortensen, Jeanette Klopchin, William Kern, and Jamie D. Ellis, and published by the UF Department of Entomology and Nematology, December 2014.
EENY613/IN1069: Wedge-Shaped Beetles (suggested common name) Ripiphorus spp. (Insecta: Coleoptera: Ripiphoridae) (ufl.edu)
Thrips in Florida Strawberry Crops
Authors: Cluever Jeffrey D. , Smith Hugh A. , Funderburk Joe E. , Frantz Galen 
Published: October 2022

Strawberries grown in Florida are attacked by several pests, including flower thrips. Western flower thrips and common blossom thrips (both invasive) can cause damage to strawberries in Florida; but, while the native Florida flower thrips is commonly found in strawberry blossoms, it hasn’t been established that it can cause economic damage to strawberry. This 9-page fact sheet describes thrips damage, characteristics to distinguish among the three species, and methods of control. Written by Jeff D. Cluever, Hugh A. Smith, Joe E. Funderburk, and Galen Frantz, and published by the UF Department of Entomology and Nematology, January 2015. (Photo: H. A. Smith)
ENY-882/IN1078: Thrips in Florida Strawberry Crops (ufl.edu)
Western Flower Thrips (Frankliniella occidentalis [Pergande])
Authors: Cluever Jeffery D. , Smith Hugh A. , Funderburk Joseph E. , Frantz Galan 
Published: October 2022

One of many species of thrips found in Florida, Frankliniella occidentalis, is a pest of several crops throughout Florida and the world, causing injury by feeding and by transmission of plant viruses. This 8-page fact sheet was written by Jeffrey D. Cluever, Hugh A. Smith, Joseph E. Funderburk, and Galen Frantz, and published by the UF Department of Entomology and Nematology, April 2015. (Photo: Lyle Buss)
ENY-883/IN1089: Western Flower Thrips (Frankliniella occidentalis [Pergande]) (ufl.edu)
Observation Bee Hives
Authors: Hall David , Ellis James D. , Sanford Malcolm 
Published: October 2022

The use of observation bee hives continues to interest a variety of people. This is not surprising. The observation hive is one of the primary research and educational tools in apiculture. It is both educational and entertaining. Observation bee hives can be used to enhance public relations and marketing programs. But a great deal of time and energy is needed to set up a hive and keep it going. Maintenance can be expensive and time consuming, especially if the hive is to be used as a permanent display for the general public. This 3-page fact sheet provides sources for building observation hives and tips for maintenance. Written by David Hall, James D. Ellis, and Malcolm Sanford, and published by the UF Department of Entomology and Nematology, March 2015. (UF/IFAS photo by Tyler Jones)
ENY131/MG320: Observation Bee Hives (ufl.edu)
Pesticide Storage: Keep It in the Container
Authors: Fishel Fred 
Published: October 2022

Accidents happen quickly, and so do accidents with pesticides. Anyone storing pesticides, especially in the presence of children, needs to take precautions by keeping them in their proper, original containers. Several people have died when they unknowingly drank pesticides from containers that originally held soda, other beverages, or foodstuffs. In particular, the herbicide paraquat is highly toxic to humans; one small accidental sip can be fatal, and there is no antidote. This 3-page fact sheet was written by Fred Fishel, and published by the UF Department of Agronomy, May 2015. (Photo: Fred Fishel)
PI255/PI255: Pesticide Storage: Keep It in the Container (ufl.edu)
Impact of Tomato Varieties and Maturity State on Susceptibility of Tomatoes to Salmonella
Authors: Marvasi Massimiliano , Hochmuth George , Teplitski Max 
Published: October 2022

Non-typhoidal Salmonella has emerged as one of the problematic human pathogens associated with fresh produce, nuts, and complex foods containing them. Recent research shows that some varieties of plants are more “resistant” to colonization by the pathogens than others. This raises the intriguing possibility that cultivar selection could be used to identify crop varieties that may be less conducive to proliferation of human pathogens. This 3-page fact sheet provides up-to-date information about tomato production practices and their relationships with Salmonella. Written by Massimiliano Marvasi, George Hochmuth, and Max Teplitski, and published by the UF Department of Soil and Water Science, December 2014. (Photo: Max Teplitski, UF/IFAS)
SL414/SS627: Impact of Tomato Varieties and Maturity State on Susceptibility of Tomatoes to Salmonella (ufl.edu)