bluuebunny/crossref_metadata_2025_split huggingface dataset:
The combined effect of different temperatures and diurnal light intensity can be an effective tool for cyanobacterial bloom management considering hydrogen peroxide as an indicator
Authors: Rahman Mizanur , Asaeda Takashi , Abeynayaka Helayaye Damitha Lakmali 
Published: December 2022

Abstract
Diurnal variations in oxidative stress conditions of cyanobacteria using laboratory experiments were conducted for assessing photoinhibition effects. The sufficient Microcystis aeruginosa cells were made in three sets at 30°C, 20°C, and 10°C for 23 days. The diurnal light changing exposure was performed after 23 days starting at 6:00 and continuing till 21:00. The samples were collected at three hour intervals — 6:00, 9:00, 12:00, 15:00, 18:00, and 21:00 — to analyze hydrogen peroxide (H2O2) concentration, protein concentration, chlorophyll-a (Chl-a) content, and catalase (CAT) activity. The production of H2O2 increased following the PAR intensity variation, with a delay of a few hours (peaking at15:00) in the different temperatures. The Chl-a content and protein concentration also declined as an effect of temperatures and the diurnal light intensities. CAT activity was proportionate to the H2O2/protein. No H2O2 concentrations detected outside cells indicated the biological production of H2O2 which was parameterized with H2O2/protein. The combined effect of different temperatures and diurnal light intensity shows that a decreasing trend of H2O2/protein is observed at 10°C compared with 30°C and 20°C. Hence, this combined effect of temperature and diurnal light change will be effective in cyanobacterial bloom treatment using H2O2 as an indicator.
Mother-infant bonding and breastfeeding in neonates with hypoxic ischemic encephalopathy or seizures
Authors: Sharpe Cynthia , Reed Peter , Borja Tania , Wang Sonya , Rassmussen Maynard , Lee Lilly , Haas Richard , Reiner Gail 
Published: December 2022

Abstract
Mother-infant bonding and breastfeeding are critical factors in the long-term outcomes of neonates. This is a first-of-its-kind exploratory study that reports the maternal bonding status and provision of breastmilk for families whose infants suffered from hypoxic ischemic encephalopathy (HIE) or neonatal seizures. Eighty-six mothers who participated in the NEOLEV2 neonatal seizure clinical trial were interviewed. Researchers surveyed mothers using the Parent Bonding Questionnaire (PBQ) and subjects provided additional qualitative comments on their experiences bonding and breastfeeding in the hospital as well as at home with their high-risk newborns. Participant interviews highlighted the impact of stressors surrounding the health and progress of their neonates that negatively impacted maternal-infant bonding as well as contributed to their inability to provide breastmilk. New mothers, in particular, reported a desire to continue breastfeeding, but felt that there was inadequate support for them. Further considerations of Whole Person Care in maternal-infant bonding, breastfeeding, mental, and postpartum support for parents of high-risk neonates could reduce long-term challenges for this vulnerable population.
Barriers to Reporting Adverse drug reaction among Health Care Providers In Ethiopia
Authors: Jifar Wakuma Wakene , Ketebo Buta Hawas 
Published: December 2022

Abstract
Background: Timely adverse drug reactions (ADRs) reporting has contributed immensely towards public health safety and adverse drug reaction reporting helps the drug monitoring system to detect the unwanted effects of those drugs which are already in the market.
Objective: To assess Barriers to Reporting Adverse drug reaction among Health Care Providers in Ethiopia.
Method: A descriptive cross-sectional study was conducted utilizing a self-administered questionnaire from the medical staff. Questions about knowledge and attitude were scored and categorized. Bivariate and multivariate logistic regressions were used to analyze the relationship between the dependent and independent variables, with a p-value of <0.05 being considered statistically significant.
Result: A total of 90 health care professionals were surveyed, and 54.4% of them were men. The availability of the ADRs reporting form was known by (51.1%) of the respondents, (81.1%) of them had encountered ADR during their practice. Sex (aOR: 2.63, 95% CI: 1.001, 7.33; p<0.001 working experience (aOR: 4.21, 95% CI: 1.54-11.32; p=0.004), and training (aOR: 3.68, 95%CI 1.14-11.68; p=0.031) were factors associated with adequate knowledge. Training was the only factor that determined ADRs reporting.
Conclusion: From this study, it can be inferred that although health care professionals have a decent level of knowledge and a favorable attitude toward ADR reporting, there is a low level of ADR reporting and training was the only factor that determined ADRs reporting.
Determinants of health seeking behaviour in South Sudan: a cross-sectional household survey
Authors: Obels Ilja , Coleman Harry , Straetemans Masja , Gurp Margo van , Lutwama George William , Jacobs Eelco 
Published: December 2022

Abstract

Background
Access to healthcare is a major challenge in South Sudan, but evidence on factors influencing health seeking behaviour (HSB) and the magnitude of these associations is limited. This study aims to identify which determinants are associated with seeking care for perceived health needs and with seeking care at private or public healthcare facilities in South Sudan.
Methods
A cross-sectional household survey was conducted in three purposefully-selected states (Central Equatoria, Western Equatoria and Warrap). A multi-stage, cluster sampling design was used. Univariable and multivariable logistic regression models were computed to explore the relationships between seeking care for perceived health needs and choice of facility, and individual and household characteristics based on an adapted Levesque framework.
Results
We identified that individuals who obtained medication (OR 2.82, 95% CI 1.52-5.22), obtained and paid for medication (OR 3.94, 95% CI 2.30-6.74), lived in Western-Equatoria (OR 9.51, 95% CI 2.35-38.53), were from the second-highest wealth quintile (OR 4.74, 95% CI 2.06-10.92) and were aware of Community Health Workers (CHWs) (OR 2.00, 95% CI 1.30-3.03), were significantly more likely to seek care for a perceived health need. Individuals who obtained and paid for medication (OR 3.16, 95% CI 1.64-6.10) and who lived further from a public health centre (OR 1.17, 95% CI 1.05-1.30) were more likely to seek care at a private facility, while individuals who used the provider before (OR 0.48, 95% CI 0.31-0.74), lived in Western Equatoria (OR 0.23, 95% CI 0.10-0.52), lived in a rural household (OR 0.34, 95% CI 0.15-0.77) and had a longer travel time to the visited health facility, were less likely to seek care at a private facility.
Conclusions
Socioeconomic status and awareness of CHWs were associated with health seeking, while distance to facilities was associated with choice of facility. Our results suggest differences in patterns of HSB between states, but studies with larger sample sizes are needed to analyse this. Furthermore, qualitative studies into access to healthcare in South Sudan could help characterise the nature of determinants and their relationship.
Captured long-read sequecing provides an efficient and accurate method for molecular diagnosis of Duchenne and Becker muscular dystrophies
Authors: LING CHAO , Dai Yi , Geng Chang , Pan Shirang , Quan Weipeng , Ding Qingyun , Yang Xunzhe , Shen Dongchao , Tao Qing , Li Jingjing , Li Jia , Wang Yinbin , Jiang Shang , Wang Yang , Chen Lin , Cui Liying , Wang Depeng 
Published: December 2022

Abstract
Background: Duchenne and Becker muscular dystrophies are not caused by deletions and duplications in the dystrophin (DMD) gene alone. A number of small and complex mutations in DMD were being found by multiple methods combined screening, including the next generation sequencing. However, there is still absent an effective method that could detect all types the potential variants in DMD. Therefore, in this study we explored a one-step detection method for DMD gene mutation based on long-read sequencing technology.
Methods: A whole DMD gene panel including 20kb flanking sequences of the up and down stream of the DMD gene was designed. Pacific Biosciences and Oxford Nanopore Technologies were used to evaluate the capture and sequencing performance of the panel. A total of 129 subjects were selected for single-blind deep investigation and validation.
Results: The results demonstrated that the long-read sequencing based DMD gene panel could integrally and accurately detect the multiple types of the variants in one-step. The noncontiguous variants were definitively corrected and attributed to translocation or inversion. Meanwhile, the micro insertion and deletion and the single nucleotide variants, especially the deep intronic variants, could be detected exactly compared with short-read sequencing technologies. Additionally, the captured long-read sequencing method could attain higher accuracy in female carrier mutation detection.
Conclusion: This study illustrated that captured long-read sequencing could uncover the real features of DMD rearrangements via the effective junction reads analysis, and provide a complete and precise insight into the DMD gene mutation. Further, improve the molecular treatment of DMD/BMDin a base-pair resolution.
Women’s alcohol Consumption During The Restriction Phases of the COVID-19 Pandemic in Brazil: a Phone Based Survey
Authors: de Vargas Divane , Ramírez Erika Gisseth León , Pereira Caroline Figueira , Filho José Adelmo da Silva , Lima Ana Vitória Correa , Marques Dionasson Altivo , Volpato Rosa Jacinto , Santos Lucas Cardoso dos 
Published: December 2022

Abstract

Background: Women were more prone to consuming alcohol as a coping mechanism, towards the COVID-19 pandemic stressors than men. There are worldwide evidences of an increase in this consumption during the social restriction phases and its association with negative impact on women's health conditions. The study aimed to describe women’s alcohol use throughout the restriction phases of the COVID-19 pandemic in São Paulo, Brazil. Method: Cross-sectional survey based on telephonic self-reports, and enrolled women who sought health care at primary health care. The sample comprised 3252 women, of whom 1308 (40%) reported consuming alcohol. The independent variable was the timing of the COVID-19 pandemic’s restriction phases. Data collection was based on telephonic self-reports, and enrolled women who sought health care at primary health care. The AUDIT-C was used as a measurement instrument. The covariates included socio-demographics, lifestyle, and outcomes related to the COVID-19 infection. Univariate and multivariate models were used for analysis. A generalized linear model with a negative binomial distribution and zero inflation for the AUDIT-C score as an outcome variable was used for the entire sample.
Findings: Women’s alcohol consumption during the COVID-19 restriction phases was compatible with moderate-risk use 3.5 (SD=2.9). Binge drinking was observed in 41.8% of the participants. Alcohol consumption was 28.9% higher in the transition phase of social restriction than in the restriction and flexibilization phases. Hospitalization for COVID-19 and loss of loved one due to COVID-19 were associated with alcohol consumption. Conclusions: Women presented a pattern of moderate risk of alcohol. This consumption were higher during the restriction phase of the pandemic in South America’s largest city; tehrefore, it brought important reflections on the women’s pattern of alcohol consumption revealing social and clinical vulnerability of this population, which might be taken into account in future health policies and programs.
A case report on intracranial subdural hematoma following spinal anesthesia: A rare complication of a common procedure
Authors: Zewde Yared Z. , Ali Kemal , Getahun Betelhem , Sintayehu Mamaru 
Published: December 2022

Abstract
Introduction: Intracranial subdural hematoma is a rare complication of lumbar puncture and spinal anesthesia. The presenting symptoms mimic other benign conditions such as post dural puncture headache which often led to mis-and delayed-diagnoses. With high degree of suspicion and proper intervention fatal outcomes can be avoided.
Case presentation: A 36-year-old HIV+ primigravida mother underwent a cesarean section under spinal anesthesia for an indication of non-reassuring fetal heart rate two weeks back. After the procedure, she reported mild occipital headache which was precipitated by upright postural. With a diagnosis of post dural puncture headache, conservative management was started and her headache subsequently improved. On day four, both the mother and her baby discharged home. A week later the patient developed occipital headache which gradually worsen and become unremitting with associated diplopia, blurred vision, neck pain and vomiting which forced her to visit the emergency department at Tikur Anbessa Specialized Hospital. Except moderate nuchal rigidity her physical examination was unremarkable. Brain imaging was requested and revealed bilateral acute and subacute subdural hematoma without mass effect. After neurosurgical consultation, conservative management with bed rest, hydration and oral analgesics was initiated. On day ten her headache and other symptoms significantly improved. She was discharged with outpatient follow-up.
Conclusion: Clinicians should be vigilant about the evolving nature of post dural puncture headache and the possibility of intracranial subdural hematoma when patients presented with persistent or worsening headache which becomes non-positional following dural puncture and spinal anesthesia. Early detection and proper intervention are imperative to avoid permanent disability or mortality.
Somatic embryogenesis processes and changes in endogenous hormone content of Cinnamomum camphora L.
Authors: Guo Haoran , Li Jingman , Ma Yu , Zhu Zhongfeng , Du Li 
Published: December 2022

Abstract
Immature zygotic embryos of the camphor tree were used as explants, under dark conditions, the somatic embryos induction rate (68.75%) was the highest when the immature zygotic embryos were 6 mm in size. And using sucrose as a carbon source was more conducive to the induction of somatic embryos. The highest cotyledon embryos proliferation rate (36.67%) appeared in the combination of 1.2 mg/L 6-BA + 0.2 mg/L IBA + 8.0 mg/L GA3, and the highest cotyledon embryos germination rate (20%) appeared at 2.4 mg/L 6-BA + 0.4 mg/L IBA + 4.0 mg/L GA3. Changes of endogenous hormone content and radio of various types of embryogenic cultures were clearly diverse: IAA and ABA were always at higher levels, and the highest values of GA3 (0.31 ng·g-1) and ZT (0.09 ng·g-1) appeared in SEG explant, and ZT was only detected in SEG explant, it is speculated that appropriately increasing the content of endogenous ZT or the concentration of exogenous cytokinin may help to induce germination of somatic embryos. The highest values of ABA/IAA (8.46) occurred in SEG explant, followed by SE explant (2.83), which was initially thought to be related to the development and germination of somatic embryos. The highest values of ABA/GA3(180.00) were found in SE explant, followed by YC explant (69.50), which indicated that a higher ratio was beneficial to the normal development of somatic embryos.
Study of the effectiveness of a ZnO–TiO2 formulation in the degradation of humic substances in mature leachate by solar photocatalysis
Authors: Nohara Nicoly Milhardo Lourenço , Filho Hélcio José Izário , Siqueira Adriano Francisco , de Aguiar Leandro Gonçalves , de Oliveira Gabriel Caracciolo Koenigkam , Nohara Evandro Luís , Alcântara Marco Aurélio Kondracki 
Published: December 2022

Abstract
Treatment of landfill leachate is an important environmental issue, especially in developing countries such as Brazil. Advanced oxidation processes (AOPs) have been considered interesting treatment alternatives. In this study, ZnO–TiO2 mixtures were incorporated into a paint polymer matrix and fixed onto supports. Paints were applied by overlapping coat layers on plates, resulting in high film thickness (600 ± 80 µm). Treatment of mature leachate by an AOP was conducted in a plug flow reactor connected to a stirred tank under solar irradiation. The objective was to evaluate the degradation of humic acid (HA) and fulvic acid + humins (FAH). The highest HA and FAH removal efficiencies were 62% ± 4.9% and 16% ± 4.2%, respectively. The kinetic model provided an R2 of 0.974. Rate constants for HA and FAH removal were 2.96 and 1.03 × 10− 3 min− 1, respectively. Statistical models for HA and FAH degradation had R2 values of 0.96 and 0.99, respectively. Both approaches indicated that HA degradation is greater at acidic pH and higher TiO2 concentrations. FAH degradation was favored by acidic pH and higher ZnO concentrations. Statistical models showed the same significant difference in conversion between replicate runs, suggesting a uniform diffusion of fractions through catalysts.
Burglar Alarm Using Hall Sensor
Authors: Susaritha M , Chandru S , Ezhilarasan M , Anish K R 
Published: December 2022

Abstract
This paper is principally intimate the updated technology of burglar alarm using sensor. Here magnetic field sensing element plays an important role in providing the range of the magnetic field. In recent days robbery in home and department stores are increasing more frequently. Due to this people feel less secure in their life. Burglar alarm is the technology that uses sensors to detect and measure the magnetic field strength. To avoid this type of scenario here comes burglar alarm system. This alarm indicates whether there is any theft in home, bank, office, jewelry shops, grocery stores and in many other places. This updated alarm system includes a sensing element which will detect magnetic field and translate them into commands for the alarm to initiate the move. This paper offers an updated system of burglar alarm using hall sensor. The sensor detects the magnetic field and passes the information about magnetic field strength and the output is displayed in the 16x2 LCD display.
Optimized Train Dispatching and Rescheduling During a Disruption in a Bottleneck Section
Authors: Byegon Danson , Bisrat Birhanu Reesom , Gashaw Sosina M. 
Published: December 2022

Abstract
Railway transportation is nowadays becoming one of the most preferred mode of transport due to its safety, capacity and reliability; the capital cost for the construction of the railway infrastructure is however very high and is characterized by high rigidity as the track layout is fixed; therefore there is need to optimally use the available infrastructure. Minor delays arising from a simple disruptions or even a single train failure can have massive impacts in terms of overall delays for subsequent trains using the track facility if not solved amicably. Disruptions can be attributed to power outages, mechanical failures, derailments, accidents or even environmental factors. In a case of multiple uncertain perturbations happening in a busy complex railway network, where there are many trains requesting to use the available track resources concurrently, there will be massive delays which has a lot of negative operational and economic implications as well as passengers’ dissatisfaction. A mathematical model that is; a mixed-integer linear programming formulation is modelled to minimize total time delays in case of a set of multiple disruptions occurring on a busy track section i.e. bottleneck section, the model is formulated with consideration of sets of constraints factoring in feasible routes and safety margins and other operational dynamics such as dwell times to achieve optimal use of the available infrastructure. A number of numerical experiments based on arbitrary data and real network data are carried out to verify the effectiveness and efficiency of the proposed model. Performance of the designed model is evaluated and results are validated, the results obtained shows that the model offers an efficient rescheduled trains operation plan during disruptions, furthermore the performance of Fmincon solver and genetic algorithms (GA) are compared and their robustness evaluated, GA shows better performance during multiple disruption scenario.
DDdeep: deep learning-based text analysis for depression illness detection on social media posts
Authors: Keyvanpour Mohammad reza , Mehrmolaei Soheila , Gholami Faezeh 
Published: December 2022

Abstract
Recently, depression has been raised as one of the most popular mental health disorders in the world. Also, social networks can be considered a valuable resource for mental health research due to the tendency of users for sharing their thoughts and feelings. On the other hand, text analysis of user posts relying on neural networks for such research is increasing. Neural networks have recently achieved significant success in text analysis because of the ability to automatically extract distinguishing features from data. However, neural networks are ignored the temporal and sequential nature of users' posts on social networks which affects the accuracy of the results. This shortcoming prompted us to present a more efficient method considering the sequential and temporal nature of social media users' posts. Thus, we have proposed a deep learning-based hybrid method called DDdeep to handle the mentioned challenge. There are three main features in our method, which are (1) text analysis relying on the temporal and sequential nature of posts, (2) identifying depressed users only by considering how users use language, and (3) remembering decisions because of the dependence of each post on previous posts. The DDdeep method has integrated a convolutional neural network (CNN) to extract more important features and long-short term memory (LSTM) to remember previous decisions. Our method identifies the depressed users by 78% precision, 70% recall, and 73% F1-score. Therefore, the evaluation results of our method are acceptable and competitive compared to other valid methods in this field.