bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case Control Study on Risk Factors of Obesity Among Adolescents
Authors: Grace G Angeline , Edward Shanthi , S Gopalakrishnan 
Published: June 2022

Background: Adolescence is the transition period from childhood to adulthood and adolescent obesity can lead to systemic complications affecting the quality of life in later stages. This study aimed to assess the risk factors of obesity among school children of adolescent age.
Methods: This Case control study included 110 obese and 110 non-obese adolescents between 10 and 17 years of age. Children with Body Mass Index (BMI) >+2 SD of WHO growth reference median for their age and sex were included as cases. Children with BMI between -2SD and +1SD were included as controls. Data was collected using a structured questionnaire and analyzed with SPSS software.
Results: The risk factors which showed a statistically significant association with adolescent obesity were less educated father and mother, being a single child in the family, adolescents from nuclear type of family, having an obese parent, increased waist hip ratio and lack of exclusive breastfeeding during infancy.
Conclusion: Educating children and parents on the importance of preventing obesity and harmful effects of adolescent obesity is the need of the hour. This can be done through intensive health education campaigns in community and schools, and regular reinforcement on primary preventive measures.
Impact Of Communication Skills Training in Postgraduate Medical Education
Authors: KK Shyamala  , Kulkarni Vasudha , Shenoy Vasanth , Bidhata Khatri  , Thapashwi  , TA Lakshmi , Joseph Mary 
Published: June 2022

Background: Effective communication is a key feature of optimal doctor-patient relationship. As the postgraduate curriculum lacks standardized teaching and assessment, this study aimed to assess effectiveness of training program on communication skills of postgraduate medical students.
Materials and methods: A prospective interventional study was conducted among first year postgraduate medical students from different clinical specialty. Training program included introduction to principles of communication with basics of doctor-patient relationship, administering informed consent, breaking bad news and counselling patients with HIV/cancer. Pre-test and post-test skill assessment by Faculty and postgraduate (PG) self-rating was carried out using KEECC-A Assessment tool for seven core communication competencies. Perception of students on training program was collected via feedback questionnaire.
Results: Forty-three postgraduate medical students participated. Statistically significant increase in communication skills scores post training was observed with mean post-test assessment scores of 24.26±2.94, p<0.001(faculty rating), 25.19±3.76, p<0.001(PG self-rating) and high degree of internal consistency was found. Students perceived the training program as valuable and highlighted its importance as a part of curriculum.
Conclusion: Training program significantly enhanced communication skills of postgraduate medical students. Integration of standardized teaching and assessment of communication skills is essential for better healthcare practice and optimal doctor-patient relationship.
การลดการลดความสูญเปล่าในกระบวนการผลิตชิ้นส่วน ฮาร์ดดิสก์ไดรฟ์ (HDD) โดยเทคนิค ECRS
Authors: Nunthaphan Kanoksirirujisaya  , Satit Srininpan  , Suthasinee Ratchabut  
Published: June 2022

งานวิจัยนี้มีวัตถุประสงค์ เพื่อลดความสูญเปล่าในสายการผลิตชิ้นส่วนอุปกรณ์ฮาร์ดดิสก์ไดรฟ์ (HDD) โดยประยุกต์ใช้เทคนิค ECRS เพื่อลดความสูญเปล่าในกระบวนการผลิตแขนจับหัวอ่านฮาร์ดดิสก์ไดรฟ์เพื่อลดการไหลงานที่ไม่ จำเป็นออกจากกระบวนการ การรวมงานที่คล้ายกันเข้าด้วยกัน และจัดเรียงใหม่เพื่อให้เกิดความสมดุลของสายการผลิตโดยการ ลดความสูญเปล่าที่เกิดจากคนทำงานมากเกินไป และลดงานที่ไม่ก่อให้เกิดมูลค่าเพิ่ม (Non-value Added) ผลการปรับปรุงปรากฏว่าสามารถลดคนจาก 5 คน เหลือ 3 คน เวลาการว่างงานลดลงจาก 5,463 วินาที/Lot เหลือ 1,597 วินาที/Lot คิดเป็น 70.6% ประสิทธิภาพการทำงานเพิ่มจาก 42% เป็น 83% คิดเป็น 41%
การปรับปรุงกระบวนการขึ้นรูปแป้งฝุ่นอัดแข็งเพื่อลดความสูญเปล่า: กรณีศึกษา สายการผลิตแป้งฝุ่นอัดแข็งบริษัทตัวอย่าง
Authors: Yuthanarong Jongjon  , Sarinya Prateepchanachai  , Tanatat Monmongkol  
Published: June 2022

งานวิจัยนี้เป็นการศึกษากระบวนการขึ้นรูปแป้งฝุ่นอัดแข็งของบริษัทตัวอย่าง ปัจจุบันมีวันทำงาน 26 วันต่อเดือน มียอดใบสั่งผลิตเฉพาะรุ่นตัวอย่าง 78,000 ชิ้นต่อเดือนหรือต้องผลิตให้ได้ 3,000 ชิ้นต่อวัน แต่สายการผลิตสามารถผลิตได้ไม่เกิน 2,000 ชิ้น ในเวลาทำงานเฉลี่ยปกติต่อวัน 8 ชั่วโมง ทำให้สายการผลิตต้องเปิดทำงานล่วงเวลา 4 ชั่วโมงต่อวัน ส่งผลทำให้ต้นทุนต่อหน่วยของผลิตภัณฑ์เพิ่มขึ้น ผู้วิจัยใช้หลักการสามจริง เพื่อลงไปสังเกตการณ์สถานที่ผลิตจริง ชิ้นงานจริง และเก็บข้อมูลตามความเป็นจริง นำมาวิเคราะห์ปัญหาด้วยเครื่องมือควบคุมคุณภาพแบบใหม่ พบว่าปัจจุบันจังหวะการทำงานของเครื่องอัดแป้งฝุ่นสามารถอัดแป้งได้จังหวะละ 1 ชิ้น และพนักงานสามารถปล่อยถาดรองแป้งลงสายพานลำเรียงได้เพียง 1 แถว เนื่องจากมืออีกข้างต้องตักแป้งฝุ่นใส่กรวยเพื่อปล่อยลงถาด ทำให้พนักงานเกิดความเมื่อยล้า นำข้อมูลที่ได้จากการวิเคราะห์มาตั้งคำถาม 5W1H เพื่อกำหนดแนวทางการแก้ไข สรุปผลการตั้งคำถามออกแบบและจัดสร้างเครื่องอัดแป้งฝุ่นให้สามารถทำงานได้มากกว่า 1 ชิ้น ใน 1 จังหวะการทำงาน และออกแบบอุปกรณ์ที่ใช้ในการปล่อยถาดรองแป้งอัตโนมัติเพื่อลดความเมื่อยล้าของพนักงาน ผลจากการดำเนินงานพบว่าเครื่องอัดแป้งฝุ่นที่ออกแบบและจัดสร้างขึ้นใหม่สามารถทำงานได้ 4 ชิ้นต่อการทำงาน 1 จังหวะ และเครื่องปล่อยถาดสามารถปล่อยถาดรองอัดแป้งลงสายพานได้ครั้งละ 2 แถว แบบอัตโนมัติ สามารถลดการทำงานล่วงเวลาของสายการผลิตได้ และมีระยะคืนทุน 390 วัน
คำสำคัญ: แป้งฝุ่นอัดแข็ง, ระยะเวลาคืนทุน, เครื่องมือควบคุมคุณภาพแบบใหม่
ENSINO FORMAL E A ATUAÇÃO DO PEDAGOGO FRENTE AO SISTEMA PRISIONAL MINEIRO
Authors: Marzola dos Santos Adriana , Costa William Ezequiel 
Published: June 2022

Grande parte dos indivíduos privados de liberdade não concluíram o ensino fundamental, consequentemente não tiveram melhores desempenhos no ensino médio e superior. Sendo assim, o tempo de cárcere pode ser melhor aproveitado quando dotado de oportunidades de estudo e profissionalização, contando não somente com a remição de pena, mas também com a oportunidade de desenvolvimento educacional/profissional. Para isso, torna-se importante imaginar maneiras de promover o ensino dentro do sistema prisional, garantindo o previsto em legislação, ou seja, acesso à educação para todos, incluindo o indivíduo em cárcere. E para que ações de implementação da educação/profissionalização sejam planejadas e postas em prática, a figura do pedagogo ganha destaque. Mas é sabido que os estabelecimentos prisionais não contam com as mesmas estruturas que o ensino regular convencional, sendo dotado de restrições inerentes ao ambiente. Realidade não diferente em Minas Gerais. E frente a essas limitações, conhecer as atribuições do pedagogo previstas na legislação mineira é fundamental para que esse profissional possa desenvolver com o máximo de êxito as ações voltadas ao ensino dentro do sistema prisional mineiro. Objetivo: Demonstrar de maneira didática e clara a importância do pedagogo frente as atividades de ensino e profissionalização dentro do sistema prisional mineiro. Metodologia: O tipo de pesquisa adotada foi a revisão de literatura narrativa seguida de visita de campo. A seleção dos documentos oficiais e dos artigos selecionados foi realizada entre meses de dezembro de 2021 e março de 2022. Sendo, entre documentos oficiais e artigos publicados, selecionadas 22 obras.
Introduction. Covid-19, droit et action publique
Authors: Dirringer Josépha , Mesnil Marie 
Published: June 2022

L’appel à contributions lancé à la fin du premier confinement lié au virus de la Covid-19, en mai 2020, soulignait le caractère inédit de la crise sanitaire. Deux ans plus tard, le soulagement d’un retour à la normale ne doit pas masquer l’importance de la rupture créée par cette crise inédite. Le système de santé a été et reste encore en première ligne. De même, l’ensemble de notre organisation, politique, économique et sociale, sommée de répondre à ce défi mondial, a été fortement ébranlé. L’introduction de ce dossier revient sur le caractère global des politiques qui ont été menées au cours de ces deux dernières années mettant ainsi en perspective les différentes contributions qui composent ce dossier.
Expression of immunogenic genes of Mycobacterium avium subsp. paratuberculosis
Authors: Manesh Kumar P , Vijayarani K , Kumanan K 
Published: June 2022

SUMMARY
Johneâ€™s disease is an economically important disease caused by Mycobacterium avium subsp. Paratuberculosis (MAP). Continuous efforts are being made to identify MAP genes with antigenic and immunogenic capabilities which may serve as vaccine candidates and diagnostic antigens. mptD and 35 KDa antigen genes of MAP amplified by Polymerase chain reaction resulted in 630bp and 830 bp products respectively. Both mptD and 35 KDa antigen genes were cloned in to pTZ57R/T cloning vector, and subsequently subcloned into pET22b and expressed in BL21 (DE3) host system. The expressed recombinant antigens could be tested in diagnostic assays and might open up the avenue for the development of newer diagnostics and vaccine candidates for Johneâ€™s disease.
TBD
Authors: Hoes Charles 
Published: June 2022

I realized that the fire-building exercise might be an almost perfect analogy to what I have been hoping to foster within the International System Safety Society (ISSS), the system safety profession or anything else applicable to this journal. Let me try to explain the connection.
For the past few decades, I have been hoping to do something to assist the ISSS in growing and becoming an organization that is as important and influential as I know it should be. I am convinced that the system safety process is highly effective and efficient at reducing risks while adding important fiscal and social value to products and systems of all kinds. I believe it is the duty/role of the ISSS to foster that process and help expand it into all industries and processes worldwide. The dual approach of integrating engineering and management practices into the process of designing, implementing and “fielding” products and systems holds the promise of a better, safer, more environmentally appropriate future. In short, I think it is a big deal.
The Effect of Retail Market Concentration on Development of Electronic Retailing in the Danube Region
Authors: Končar Jelena , Lovreta Stipe , Vucenovic Sonja , Marić Radenko 
Published: June 2022

The development of electronic retailing as a new retail marketing channel based on the Internet appears in contemporary theory and practice. In such market conditions, there is a research problem in which the level of development of the retail market and increasing concentration and competition in the market impact the development of electronic retailing. The aim to prove in this paper is to determine whether the level of concentration of the traditional retail market influences the share of electronic retailing in total retail revenue. The Danube region countries are chosen because of differences in the level of development of the retail market and electronic retailing. The sale revenues of the largest retailers based on which the level of concentration of the retail market in a particular country is determined are analyzed. The study concluded that a high share of the ten biggest retailers in the total retail revenue, as an indicator of the development of the retail market, follows the high share of e-retailing in total retail revenue to some extent. The results also confirmed a significant relation between the origin and types of retailers and the degree of concentration of electronic retail. Recommendations for future research are given in the paper.
Thermodynamic Analysis of a Closed-Cycle Ocean Thermal Energy Conversion Power Plant for Offshore Platforms
Authors: Ezgi Cüneyt 
Published: June 2022

Abstract
The world is currently facing two major challenges: global climate change and sustainable development. Efforts to generate electricity from renewable energy sources continue steadily. In this study, a closed-cycle ocean thermal energy conversion (OTEC) power plant with various working fluids with zero Ozone Depletion Potential (ODP) and per unit mass flow rate for offshore platforms is designed and thermodynamically analyzed using Engineering Equation Solver (EES). The calculated results shows that ammonia (R-717) has the highest electrical performance of 45.51 kW per unit mass flow rate among the studied working fluids for OTEC.

Introduction
The world is currently confronted with two major challenges: global climate change and sustainable development. The Paris Agreement entered into force on November 4, 2016, limited global warming to well below 2°C, preferably to 1.5°C, compared to preindustrial levels. According to the Sixth Assessment Report released by Intergovernmental Panel on Climate Change (IPCC) on February 28, 2022, climate change is causing common deterioration in every zone in the world with just 1.1°C of warming. Sustainable solutions for our environment’s future must be produced. Therefore, the power generation efforts from renewable energy sources are going on continuously.
Effect of Silver Water Produced by an Engineered Device Designed to Food Industry
Authors: Alexandar Irina , Titorenkova Sophia , Titorenkov Vladimir 
Published: June 2022

Hygienic norms in the food and beverages production systems should be permanently monitored to prevent contamination with pathogens which could cause diseases in humans and animals. As regards the industrial scale of food and beverages production, the maximum extension of the shelf life is an essential task. Peracetic acid (CH3COOOH) is frequently applied in sanitation procedures of production piping and product tanks, but if it is not rinsed well, could drastically affect organoleptic characteristics of the products. Silver water (containing Ag+) could replace the use of peracetic acid. A device for efficient production of silver water is constructed. The silver content of the water produced is determined by atomic absorption spectroscopy, UV-Vis and IR spectral analysis. It is found that minimal inhibitory concentration (MIC) of 1 μg silver content inhibited the yeast (Saccharomyces cerevisiae ATCC 200060) growth (24 ± 1 mm mean inhibition zone) on a similar rate as 30 μg kanamycin (27 ± 1 mm). Bacterial (Escherichia coli ATCC 47093) growth inhibited by 1.5 μg silver content (18 ± 1 mm) is comparable to 10 μg ampicillin (17 ± 1 mm) but not to 30 μg kanamycin (35 ± 1 mm).
Incidence of New-onset Atrial Fibrillation in Patients Presenting with Acute St-elevation Myocardial Infarction
Authors: Nadeem Kamran Awan , Shaikh Javed Khurshed , Kalwar Muhammad Hashim , Butt Muhammad Hassan , Ali Gulzar , Solangi Bashir Ahmed 
Published: June 2022

Aim: This study aims to find out the incidence of atrial fibrillation new onset in STEMI patients receiving primary PCI
Sample: A total of 169 patients have included after sample size calculation by using WHO sample size calculator version 2.0.
Study Design: Descriptive cross-sectional study
Place and Duration of Study: This study was conducted at the Department of Interventional Cardiology at the National Institute of Cardiovascular Disease (NICVD), Karachi, Pakistan from April 18th, 2020, to October 17, 2020.
Methodology: The inclusion criteria set for data collection were as; all the patients undergoing Primary PCI with age between 40 to 80 years, males and females, patients presented with 12 hours of the onset of chest pain with STEMI to enroll in the study. Whereas, patients who had a previous history of any cardiac-related surgery and known AF, also all the patients suffered AF after trial of cardioversion, and those patients who had ejection fraction less than 20% were excluded from the study.
Result: The demographic classification showed the mean age of the patients was 55.96±8.9 with a CI of 54.60 to 57.33 years. The mean height of the patients was 167.34±0.56 with CI of 166.2 to 168.46. The mean weight of the patients was 74.84±0.7 with CI of 73.39 to 76.29 kg. The average BMI of all the patients was 26.7±0.28 with CI of 26.2 to 27.33. The analysis of the data revealed that Atrial fibrillation is more common in people who don’t smoke tobacco and are non-diabetic. Diabetic patients are less prone to atrial fibrillation in MI.
Conclusion: The prevalence of new-onset of atrial fibrillation was found to be high in elderly age group patients.
Development and Validation of a Machine Learning Algorithm Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer
Authors: Noel Christopher W. , Sutradhar Rinku , Gotlib Conn Lesley , Forner David , Chan Wing C. , Fu Rui , Hallet Julie , Coburn Natalie G. , Eskander Antoine 
Published: June 2022

ImportancePatient-reported symptom burden was recently found to be associated with emergency department use and unplanned hospitalization (ED/Hosp) in patients with head and neck cancer. It was hypothesized that symptom scores could be combined with administrative health data to accurately risk stratify patients.ObjectiveTo develop and validate a machine learning approach to predict future ED/Hosp in patients with head and neck cancer.Design, Setting, and ParticipantsThis was a population-based predictive modeling study of patients in Ontario, Canada, diagnosed with head and neck cancer from January 2007 through March 2018. All outpatient clinical encounters were identified. Edmonton Symptom Assessment System (ESAS) scores and clinical and demographic factors were abstracted. Training and test cohorts were randomly generated in a 4:1 ratio. Various machine learning algorithms were explored, including (1) logistic regression using a least absolute shrinkage and selection operator, (2) random forest, (3) gradient boosting machine, (4) k-nearest neighbors, and (5) an artificial neural network. Data analysis was performed from September 2021 to January 2022.Main Outcomes and MeasuresThe main outcome was any 14-day ED/Hosp event following symptom assessment. The performance of each model was assessed on the test cohort using the area under the receiver operator characteristic (AUROC) curve and calibration plots. Shapley values were used to identify the variables with greatest contribution to the model.ResultsThe training cohort consisted of 9409 patients (mean [SD] age, 63.3 [10.9] years) undergoing 59 089 symptom assessments (80%). The remaining 2352 patients (mean [SD] age, 63.3 [11] years) and 14 193 symptom assessments were set aside as the test cohort (20%). Several models had high predictive accuracy, particularly the gradient boosting machine (validation AUROC, 0.80 [95% CI, 0.78-0.81]). A Youden-based cutoff corresponded to a validation sensitivity of 0.77 and specificity of 0.66. Patient-reported symptom scores were consistently identified as being the most predictive features within models. A second model built only with symptom severity data had an AUROC of 0.72 (95% CI, 0.70-0.74).Conclusions and RelevanceIn this study, machine learning approaches predicted with a high degree of accuracy ED/Hosp in patients with head and neck cancer. These tools could be used to accurately risk stratify patients and may help direct targeted intervention.
Adolescents’ and Young Adults’ Recommendations for Implementing Healthcare Transition in Rheumatology: A Mixed Methods Study
Authors: Carandang Kristine , Wells Courtney K. , Guglielmo Dana , Melcher Katelyn , Trimble Meghan , Ardoin Stacy P. , Chira Peter 
Published: June 2022

ObjectiveThe goal was to elicit adolescents’ and young adults’ (AYAs) perspectives about how to implement the Six Core Elements of Healthcare Transition within rheumatology care.MethodsAYAs (ages 16–28 years old) with self‐reported rheumatic conditions were recruited through patient organizations and social media. In Phase One (qualitative [QUAL]), 90‐minute focus groups were facilitated to elicit AYAs’ reactions to Six Core Elements content. In Phase Two (quantitative; QUAN), a national survey was conducted to determine generalizability of recommendations extracted from Phase One. Mixed methods analyses were conducted by a multidisciplinary team of social science researchers, pediatric rheumatologists, and patients.ResultsAlthough focus group participants (n = 39) were previously unfamiliar with the Six Core Elements, they reacted favorably to its format and content. Participants provided suggestions for how to logistically execute each component in the clinic. Additionally, 3 overarching recommendations emerged that focused on motivating AYAs to engage: 1) frame health care transition as an opportunity for empowerment; 2) implement a structured education plan; and 3) consider the role of parents. In line with qualitative findings, survey participants (n = 137) reported that they would prefer to learn most transitional skills from and discuss developmentally specific topics with their rheumatology team. Participants reported they would likely complete programs to learn transitional skills from allied professionals, via patient portals, or in group settings.ConclusionIncorporating patient perspectives into research and clinical practice is an opportunity to strengthen educational programs. AYAs emphasized the importance of gaining independence and becoming empowered through the health care transition process with structured support from their rheumatology teams.
Uncertain disturbed systems: RobustH2‐OUFIR filtering under measurement errors
Authors: López Solórzano Juan J. , Shmaliy Yuriy S. 
Published: June 2022

SummaryThis article considers uncertain disturbed systems represented under initial and measurement errors in linear discrete‐time state‐space. A novel bias‐constraineda posteriorioptimal unbiased finite impulse response (OUFIR) state observer is derived, in which the requirements of the initial state is removed by embedding the unbiasedness constraint. A suboptimal bias‐constrained ‐FIR filtering algorithms using linear matrix inequality is also obtained. Based on an example of uncertain system and error matrices, it is shown that the ‐OUFIR state observer offers a better tradeoff between the accuracy and robustness than the OFIR filter, maximum likelihood FIR filter, and Kalman filter. It loses in robustness to the unbiased FIR filter, but provides a better accuracy. The performance of the proposed filter is verified experimentally based on daily glucose measurements in diabetic persons with timing jitter.
Mutations in GCK May Lead to MODY2 by Reducing Glycogen Synthesis
Authors: Li Zongyue , Li Kunxia , Sun Yan , Jiang Xiuyun , Liu Jia , Li Jingyi , Fang Li , Li Guimei , Guan Qingbo , Xu Chao 
Published: June 2022

AbstractDysfunction of glucokinase (GCK) caused by mutations in the GCK gene is the main cause of maturity‐onset diabetes of the young type‐2 (MODY2, also known as GCK‐MODY), which is usually present in adolescence or young adulthood. MODY2 is characterized by mild, stable fasting hyperglycemia that presents at birth, usually 5.4–8.3 mmol L−1, and rarely develops complications from diabetes. The treatment of MODY2 prefers a manageable diet rather than the use of insulin. Previous studies have identified GCK mutations only by online software prediction or enzyme kinetic analysis and thermolability assays which are complicated to be conducted. In this study, six mutations in the GCK gene, including four novel mutations and two mutations that are previously reported, are identified. All the six locations are highly conserved according to the sequencing alignment. Moreover, missense mutations are strongly predicted to be pathogenic using online programs. Functional studies show that mutations in GCK mutation do not affect insulin secretion but affect glycogen synthesis. These findings demonstrate that GCK mutations decrease glycogen synthesis, which leads to hyperglycemia in MODY2. Meanwhile, this study provides a new perspective and methods for identifying pathogenic mutations in GCK.