bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delta Oscillations Coordinate Intracerebellar and Cerebello-Hippocampal Network Dynamics during Sleep
Authors: Torres-Herraez Arturo , Watson Thomas C. , Rondi-Reig Laure 
Published: January 2022

During sleep, the widespread coordination of neuronal oscillations across both cortical and subcortical brain regions is thought to support various physiological functions. However, how sleep-related activity within the brain's largest sensorimotor structure, the cerebellum, is multiplexed with well-described sleep-related mechanisms in regions such as the hippocampus remains unknown. We therefore simultaneously recorded from the dorsal hippocampus and three distinct regions of the cerebellum (Crus I, lobule VI, and lobules II/III) in male mice during natural sleep. Local field potential (LFP) oscillations were found to be coordinated between these structures in a sleep stage-specific manner. During non-REM sleep, prominent δ frequency coherence was observed between lobule VI and hippocampus, whereas non-REM-associated hippocampal sharp-wave ripple activity evoked discrete LFP modulation in all recorded cerebellar regions, with the shortest latency effects in lobule VI. We also describe discrete phasic sharp potentials (PSPs), which synchronize across cerebellar regions and trigger sharp-wave ripple suppression. During REM, cerebellar δ phase significantly modulated hippocampal theta frequency, and this effect was greatest when PSPs were abundant. PSPs were phase-locked to cerebellar δ oscillation peak and hippocampal theta oscillation trough, respectively. Within all three cerebellar regions, prominent LFP oscillations were observed at both low (δ, <4 Hz) and very high frequencies (∼250 Hz) during non-REM and REM sleep. Intracerebellar cross-frequency analysis revealed that δ oscillations modulate those in the very high-frequency range. Together, these results reveal multiple candidate physiological mechanisms to support “offline,” bidirectional interaction within distributed cerebello-hippocampal networks.SIGNIFICANCE STATEMENTSleep is associated with widespread coordination of activity across a range of brain regions. However, little is known about how activity within the largest sensorimotor region of the brain, the cerebellum, is both intrinsically organized and links with higher-order structures, such as the hippocampus, during sleep. By making multisite local field potential recordings in naturally sleeping mice, we reveal and characterize multiple sleep stage-specific physiological mechanisms linking three distinct cerebellar regions with the hippocampus. Central to these physiological mechanisms is a prominent δ (<4 Hz) oscillation, which temporally coordinates both intracerebellar and cerebello-hippocampal network dynamics. Understanding this distributed network activity is important for gaining insight into cerebellar contributions to sleep-dependent processes, such as memory consolidation.
Barriers and Motivators for Smoking Cessation Among Caregivers of Inpatient Pediatric Patients
Authors: Holstein Jacqueline A. , O’Hara Kimberly , Moss Angela , Lowary Michelle , Kerby Gwendolyn , Hovell Melbourne , Klein Jonathan D. , Winickoff Jonathan P. , Wilson Karen 
Published: January 2022

OBJECTIVE
To examine perceived barriers and motivators for smoking cessation among caregivers of inpatient pediatric patients.

METHODS
From December 2014 to June 2018, trained tobacco counselors conducted motivational interviews (MI) with caregivers of inpatient pediatric patients ages 0 to 17, who participated in the intervention arm of a smoking cessation randomized controlled trial. By using NVivo 12 software, the first MI session with each caregiver was evaluated by 3 individuals to identify and categorize motivators and barriers; agreement among reviewers was reached. Barriers and motivators were examined in bivariable analysis with χ2 or Fisher’s exact tests for categorical factors and with t-tests for continuous factors by using SAS 9.4 software.

RESULTS
Of the 124 caregivers randomized to intervention, 99 subjects (80%) completed ≥1 MI sessions. The most prevalent barriers to cessation were stress (57%) and social influence (37%).
The most prevalent motivators were desire to lead a healthy life (54%) and desire to improve the child and family’s well-being (47%). Older parent age was associated with wanting to lead a healthy life, and younger child age was associated with wanting to improve the child and family’s well-being.

CONCLUSIONS
Understanding barriers and motivators to cessation among caregivers is crucial in reducing pediatric secondhand smoke (SHS). When developing caregiver cessation programs in an inpatient clinic encounter, caregiver barriers and motivators may help in targeting education and strategies to help counselors and clinicians better identify and support caregivers who wish to quit smoking.
St. George’s mushroom, Calocybe gambosa (Fr.) Donk: A promising source of nutrients and biologically active compounds
Authors: Radović J. , Leković A. , Damjanović A. , Kopanja Đ. , Dodevska M. , Stanojković T. , Marinković T. , Jelić Č. , Kundaković-Vasović T. 
Published: January 2022

Abstract
The composition of biologically active compounds of Calocybe gambosa (Lyophyllaceae) was analysed, and the antioxidant and cytotoxic activities were tested in vitro. C. gambosa was low in energy, fat, and carbohydrates, but rich in proteins and fibres. The total polyphenol content in the extracts was low (23.08 ± 0.67 in aqueous and 24.99 ± 4.25 μg GA mg−1 of extract in methanolic extract). The methanolic extract showed anti-DPPH radical activity with an IC50 of 626.10 ± 25.20 μg mL−1. The sample of C. gambosa is rich in nucleotides and amino acids responsible for its pleasant taste. The nucleoside and 5′-monophosphates contents were 0.97 mg g−1 and 2.32 mg g−1 of dry mushroom, respectively. The contents of essential and non-essential amino acids were 18.41 ± 0.06 and 41.75 ± 0.30 mg g−1 d.w., respectively. The percentages of saturated and unsaturated fatty acids were 42.6% and 57.4%, respectively. The most abundant water-soluble and fat-soluble vitamins were B1 and E, respectively. Cytotoxic effect of the extracts was examined against different cancer cell lines, and the best cytotoxicity was showed by the peptide extract against colon cancer cell line LS174.
Kvalitatív longitudinális vizsgálat a Szegedi Tudományegyetem külföldi hallgatóinak elégedettségéről és lojalitásáról
Authors: Kéri Anita 
Published: January 2022

Összefoglaló. A felsőoktatás nemzetköziesedése régóta foglalkoztatja
a hazai kutatókat, így a külföldi hallgatók véleményének és a magyar
felsőoktatás által nyújtott képzésminőségnek a vizsgálata igencsak kiterjedt.
Jelen tanulmány célja, hogy a külföldi hallgatók elvárásainak és
elégedettségének változásait, valamint lojalitását vizsgálja egy három éven
keresztül tartó longitudinális mélyinterjúsorozat segítségével. A paneles
kvalitatív kutatás eredményei azt mutatják, hogy a vizsgált hallgatók elvárásai
és elégedettsége is változik az idő előrehaladtával és a képzés végének
közeledtével, lojalitásuk pedig nem csupán az egyetemmel kapcsolatosan, de a
külföldi tanulási élménnyel kapcsolatosan is kialakulhat.
Summary. The internationalization of higher education has long been
at the centre of research interest. Therefore, the opinion of foreign students
and the study of Hungarian higher education institutions’ service quality are
researched widely. The aim of the current study is to shed light on the changes
in foreign student expectations and satisfaction and to examine their loyalty
with a longitudinal panel interview series over three years. Research results
show that foreign student expectations and satisfaction change with time and
loyalty can appear towards the institution and the foreign study experience,
too.
Ocidente pós-11 de Setembro: perversão de ideais religiosos e a representação midiática do terrorismo
Authors: Sanches Lilian Ribeiro 
Published: January 2022

Com base nos postulados de Bauman, Morin, Moscovici e Rapoport, o presente artigo se propõe a investigar a relação travada entre o projeto autoritário da Al Qaeda, que teve seu ápice com a concretização dos ataques de 11 de Setembro, e a influência da mídia na construção da representação social do terrorismo no Ocidente. De forma até então inédita, a instrumentalização política dos acontecimentos contribuiu para a disseminação de um pânico moral a partir do que se convencionou chamar de "ameaça terrorista", ampliando a percepção de poder do grupo entre a opinião pública, desencadeando a "guerra ao terror" e cristalizando estereótipos. Com o intuito de fomentar o debate sobre o tema, o trabalho pretende apresentar uma análise quantitativa da cobertura jornalística das edições digitais da Folha de S.Paulo e The New York Times nos marcos de um, dez e quinze anos após o 11 de Setembro.
Mentorship programmes in public primary schools: Beginner teachers’ perspectives.
Authors: Mpisi Anthony , Zoutendijk Nerissa 
Published: January 2022

Many beginner teachers experience the transition from student teacher to beginner teacher as challenging and a huge reality shock. These adapting demands are often daunting and they therefore need assistance to navigate the transition. The researchers argue that mentorship programmes can assist in addressing these transition challenges. The study makes the point that literature on teacher mentorship in South Africa has largely been from the perspective of administrators, designers and providers of mentorship programmes, rather than from the perspective of the beginner teachers themselves. The aim of the study was therefore to ascertain the perception of beginner teachers in public primary schools in the Ugu district of KwaZulu-Natal, South Africa, on mentorship programmes. The study was framed within the constructionist theoretical framework and made use of the qualitative approach, using structured interviews as a data collection instrument. The study revealed that beginner teachers experienced challenges with administration, classroom management and adjusting to the school environment. The findings further revealed that existing informal mentorship programmes failed to adequately address these challenges and meet beginner teachers’ professional needs. The researchers, however, argue that formal and well-designed mentorship programmes potentially have the ability to address the challenges beginner teachers encounter.
Pengamalan Al-Qur`an Perspektif Post-Feminisme Simone De Beauvoir
Authors: Mujahidin Saekul 
Published: January 2022

<p>Kesetaraan gender merupakan diskursus yang masih tetap hangat diperbincangkan bahkan menjadi perdebatan para feminis Muslim sampai sekarang. Penggagas dan pendukung kesetaraan gender tidak jarang mempersoalkan hukum Islam yang dianggap kurang adil dalam memposisikan laki-laki dan perempuan. Bermula dari kesadaran akan ketertindasan perempuan oleh sistem yang patriakis inilah muncul kajian tentang perempuan yang kemudian diistilahkan “<em>feminisme”</em> salah satu gagasannya adalah pembebasan yang mengkonsentrasikan pada upaya pengangkatan drajat perempuan agar bisa setara dengan kaum laki-laki dan bebas dari eksploitasi dan tidak mengenal adanya diskriminasi jenis kelamin. Simone De Beauvoir adalah salah satu tokokh feminis yang menyuarakan kebebasan perempuan akan kedudukan mereka yang berbeda dari laki-laki. kebebasan perempuan haruslah didukung oleh semua pihak dan membuat mereka mampu untuk menjadi dirinya sendiri, mampu untuk memilih dan menentukan sikap Menurut Simone de Beauvoir, perempuan dikonstruksikan oleh laki-laki melalui struktur dan lembaga laki-laki. Karena perempuan tidak memiliki esensi seperti juga laki-laki, jadi perempuan tidak harus menjadi apa yang diinginkan oleh laki-laki. Perempuan dapat menjadi subjek dengan terlibat dalam kegiatan positif dalam masyarakat. Hal ini juga sejalan dengan semangat Q.S an-Nisa/4: 32 adanya hak bagi laki-laki dan perempuan untuk terlibat di wilayah publik. Menurut de Beauvoir, strategi yang dapat dilakukan perempuan untuk tidak tertindas dari laki-laki, adalah : Pertama, perempuan dapat bekerja. Kedua<strong><em>,</em></strong> perempuan menjadi seorang intelektual. Ketiga<strong><em>,</em></strong> perempuan mampu mandiri. Gagasan ini juga sejalan dengan semangat Q.S at-Taubah/9: 71 bahwa laki-laki dan perempuan mempunyai hak dan derajat yang sama dalam setiap aspek kehidupan seperti berbuat yang <em>ma’ruf </em>dan menjauhi yang <em>munkar</em>. Konsep yang digagas de Beauvoir ini disebutnya sebagai post-feminisme. </p>
Perbandingan Tingkat Kesehatan Bank Pembiayaan Rakyat Syariah di Pulau Jawa pada Sebelum dan Saat Masa Pandemi
Authors: Sari Henny Rahma , Canggih Clarashinta 
Published: January 2022

<p><em>The study </em><em>aimed to </em><em>compar</em><em>e the Islamic Rural Banks (BPRS) soundness on Java area</em><em> </em><em>before and during the pandemic. The research is a quantitative study using secondary data obtained from the </em><em>monthly Islamic </em><em>B</em><em>anking statistics</em><em> </em><em>published by Otoritas Jasa Keuangan. </em><em>T</em><em>he sample was DPK, NPF, and FDR of BPRS in 6 provinces at Java island from May 2019 until November 2020. The analysis of the data in this study use</em><em>d</em><em> Wilcoxon analysis. The results of the study indicate</em><em>d</em><em> there is a different </em><em>of BPRS soundness, represented by DPK, NPF, and FDR</em><em> </em><em>b</em><em>efore and during the pandemic covid-19. <span style="text-decoration: line-through;"> </span></em></p>
Imaging of Mitral Valve Area by Cardiac Magnetic Resonance in Patients with Rheumatic Mitral Stenosis
Authors: bedier ahmed , sakrana amal 
Published: January 2022

Abstract
Background: Rheumatic heart disease which is a result of rheumatic fever is still a major health problem in developing countries. Rheumatic mitral stenosis (MS) is the commonest delayed valvular affection as a consequence of rheumatic fever. The assessment of MS severity by measuring mitral valve area (MVA) is very essential for patient management. Different imaging modalities are available for MVA assessment including echocardiography and cardiovascular magnetic resonance (CMR).Objectives: The aim of this study is to compare the planimetric MVA between CMR and two dimensional echocardiography in MS patients.Patients and methods: A forty adult patients with symptomatic mitral stenosis were included in the study. Other significant valvular lesions, atrial fibrillation, poor echocardiographic window, contraindications to CMR, and NYHA IV were excluded from the study. All patients were assessed by 2D echocardiography and CMR for MVA measurement.Results: the mean 2D TTE MVA was 1.2±0.26 cm2, while the mean CMR MVA 1.2±0.28 cm2. No significant statistical difference was found between both methods (P value 0.842) with a very strong correlation between both methods (r = 0.93 and p-value < 0.0001). The mean difference of MVA between the two methods was 0.012 cm2.Conclusion: CMR is a non-invasive imaging modality that provides MVA measurement and is a reliable method in the diagnosis of MS patients.
Primary Healthcare Competencies Needed in the Management of Integrated and Person-centred Care for Chronic Illness and Multimorbidity
Authors: Michielsen Leslie , Bischoff Erik W.M.A. , Schermer Tjard , Laurant Miranda 
Published: January 2022

Abstract
Background: Chronic disease management is important in primary care. Disease management programs focus primarily on the disease. The occurrence of multimorbidity and social problems is addressed to a limited extent. Person-centred integrated care as an alternative approach empowers patients to become active participants. In this scoping review we explore necessary competencies for healthcare professionals working in collaborative teams where the main focus lies within the concept of person-centred integrated careMethods: Six literature databases and grey literature were searched for guidelines and peer-reviewed articles. A thematic synthesis was carried out to highlight healthcare professionals competencies that are needed to deliver person-centred integrated care.Results: Four guidelines and 21 studies were included to identified four themes; interprofessional communication, interprofessional collaborative teamwork, leadership and patient-centred communication. Included papers lack a description of competencies core concepts, such as healthcare professionals knowledge, skills and attitudes necessary for a person-centred integrated care approach or details on how these competencies can be acquired.Conclusion: This review provides an integrative view on competencies necessary to provide person-centred integrated care within primary care. Details on core concepts of these competencies are lacking. More research is needed, on competencies and educational programs to ensure healthcare professionals in primary care are better equipped to deliver person-centred integrated care for chronic ill patients.
Oxygen Stable Electrochemical CO2 Capture and Concentration through Alcohol Additives
Authors: Yang Jenny , Barlow Jeffrey 
Published: January 2022

Abstract
Current methods for CO2 capture and concentration (CCC) are energy intensive due to their reliance on thermal cycles, which are intrinsically Carnot limited in efficiency. In contrast, electrochemically driven CCC (eCCC) can operate at much higher theoretical efficiencies. However, most reported systems are sensitive to O2, precluding their practical use. In order to achieve O2 stable eCCC, we pursued the development of molecular redox carriers with reduction potentials positive of the O2/O2- redox couple. Prior efforts to chemically modify redox carriers to operate at milder potentials resulted in a loss in CO2 binding. To overcome these limitations, we used common alcohols additives to anodically shift the reduction potential of a quinone redox carrier, 2,3,5,6-tetrachloro-p-benzoquinone (TCQ), by up to 350 mV, conferring O2 stability. Intermolecular hydrogen-bonding interactions to the dianion and CO2-bound forms of TCQ were correlated to alcohol pKa to identify ethanol as the optimal additive, as it imparts beneficial changes to both the reduction potential and CO2 binding constant, the two key properties for eCCC redox carriers. We demonstrate a full cycle of eCCC in aerobic simulated flue gas using TCQ and ethanol, two commercially available compounds. Based on the system properties, an estimated minimum of 21 kJ/mol is required to concentrate CO2 from 10% to 100%, or twice as efficient as state-of-the-art thermal amine capture systems and other reported redox carrier-based systems. Furthermore, this approach of using hydrogen-bond donor additives is general and can be used to tailor the redox properties of other quinones/alcohol combinations for specific CO2 capture applications.
Rikkunshito Increases Incretin Levels in Patients Underwent Pylorus-Preserving Pancreatico-Duodenectomy: A Case Control Study
Authors: Kono Hiroshi , Hosomura Naohiro , Amemiya Hidetake , Shoda Katsutoshi , Furuya Shinji , Akaike Hidenori , Kawaguchi Yoshihiko , Kawaida Hiromichi , Ichikawa Daisuke 
Published: January 2022

Abstract
Background
Rikkunshito (TJ-43) improves the gastrointestinal disorders by increasing levels of active ghrelin which is belonging to gastrointestinal hormones; however, effects of TJ-43 on other gastrointestinal hormones are still unknown. Accordingly, the purpose of this study was to investigate effects of TJ-43 on other gastrointestinal hormones and incretins including gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), which activate the islet cells in the pancreas.
Methods
Forty-one patients who underwent pylorus-preserving pancreatico-duodenectomy (PpPD) due to pancreato-biliary tumors were divided into two groups; patients were received TJ-43 (7.5 g daily dose) just after surgery [TJ-43(+) group, n = 21] or 3 weeks after surgery [TJ-43(−) group, n = 20]. Blood samples were collected for analysis of regular clinical blood tests at designated time points. In addition, active and inactive form of ghrelin, spexin, cholecystokinin (CCK), peptide YY (PYY), gastric inhibitory peptide (GIP), and glucagon-like peptide-1 (GLP-1) levels were assayed by ELISA. One week after surgery, meals were starting and oral calorie intake was assessed both in the two groups after starting meals. Insulin secretion was also assessed.
Results
Active form of ghrelin levels significantly increased in the TJ-43(+) group compared with the TJ-43(−) group. Reflecting this result, oral intake of staple food (carbohydrate) significantly increased in the in the TJ-43(+) group. Levels of spexin slightly decreased after PpPD in the TJ-43(−) group and were not changed in the TJ-43(+) group before and after surgery. Levels of CCK and PYY were not different before and after surgery in the TJ-43(−) group; however, these levels increased significantly in the TJ-43(+) group. Alternatively, GIP and GLP-1 levels decreased in the TJ-43(−) group after PpPD. Importantly, these levels significantly increased in the TJ-43(+) group compared with the TJ-43(−) group. Although there were no significant differences between the TJ-43(+) group and the TJ-43 (−) group, insulin secretion increased in the TJ-43(+) group.
Conclusions
TJ-43 treatment increased expression of incretins in addition to active ghrelin. Thus, it could have advantage for oral food intake and blood sugar control in patients after pancreatic surgery.
The Role of Estrogen Receptor β in PM2.5 Organic Extract-Induced Pulmonary Inflammation in Female and Male Mice
Authors: Guo Huaqi , Yu Hengyi , Feng Yan , Cheng Wei , Li Yan , Wang Yan 
Published: January 2022

Abstract
Automobile exhaust is one of the main sources of PM2.5 in urban areas, and traffic-originated PM2.5 organic extract (Po) can promote inflammation in different organs, especially in the lung. In addition, sex differences were reported in many inflammatory diseases, but the triggering factors of sex differences in inflammatory responses are still unclear. In this study, we investigated the effects of Po exposure on pulmonary inflammatory responses and evaluated the role of sex in this process. Mice were exposed to 100 µg/m3 Po for 12 weeks by an inhalation exposure system in a polycarbonate chamber. In Po-exposed mice, the lung histopathological analysis shown obvious inflammation, the cell numbers in bronchoalveolar lavage fluid (BALF) were significantly increased, and most inflammatory cytokines in BALF were upregulated. Factorial analysis of variance was carried out to investigate the interaction between sex and Po exposure in these effects. The results shown that the increase of inflammatory cell numbers and the fluctuation of cytokine levels (TNF-α, IL-5, and GRO/KC) in BALF induced by Po were significantly different between female and male mice. Notably, these differences were diminished while Po-exposed mice were injected with PHTPP, an ERβ antagonist (1 mg/kg, i.p.). We hypothesized that Po-induced inflammatory responses were different between female and male mice, and ERβ was involved in these processes. To our knowledge, this is the first investigation about the role of sex in Po-induced adverse effects. This study provided a theoretical basis for understanding the sex differences in the adverse effects of environmental pollutants.