bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous decolorization of anionic and cationic dyes by 3D metal-free easily separable visible light active photocatalyst
Authors: Mansor Eman S. , El Shall Fatma N. , Radwan Emad K. 
Published: September 2022

AbstractTo overcome the hard and costly post-treatment separation of ultrathin graphitic carbon nitride nanosheets (UGCN), it was supported on polyurethane foam (PUF). The ratio of PUF/UGCN was optimized for the removal of a mixture of methylene blue (MB) and methyl orange (MO) dyes. The characteristics of the composite photocatalyst and its photocatalytic performance were detailly studied. The X-ray diffraction and Fourier transform infrared results proved the successful preparation of UGCN and PUF and that the PUF/UGCN composite combines the features of both pure materials. The transmission electron microscopy illustrated the ultrathin nanosheet shape of the UGCN, while the scanning electron microscope showed the highly porous 3D-hierarchical structure of PUF. Compared to the pure components, the composite photocatalyst with PUF/UGCN mass ratio of 4 achieved better decolorization of MO and almost same decolorization of MB as UGCN. Neutral pH and 1 g/L of the composite photocatalyst were the optimum conditions for MB/MO mixture decolorization. The composite photocatalyst kept its efficiency for five successive cycles. Hydroxyl radicals were the dominant in the degradation of MB, while superoxide radicals were the most influencer in MO degradation. Conclusively, supporting UGCN onto PUF kept the photocatalytic efficiency of UGCN toward MB decolorization and improved its efficiency toward MO. Moreover, it enabled the reuse of the composite photocatalyst and facilitated the post-treatment separation process.
Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle
Authors: Brook Matthew S. , Wilkinson Daniel J. , Tarum Janelle , Mitchell Kyle W. , Lund Jonathan L. , Phillips Bethan E. , Szewczyk Nathaniel J. , Kadi Fawzi , Greenhaff Paul L. , Smith Ken , Atherton Philip J. 
Published: September 2022

AbstractAgeing limits growth capacity of skeletal muscle
(e.g. in response to resistance exercise), but the role of satellite cell (SC) function in driving this phenomenon is poorly defined. Younger (Y) (~ 23 years) and older (O) men (~ 69 years) (normal-weight BMI) underwent 6 weeks of unilateral resistance exercise training (RET). Muscle biopsies were taken at baseline and after 3-/6-week training. We determined muscle size by fibre CSA (and type), SC number, myonuclei counts and DNA synthesis (via D2O ingestion). At baseline, there were no significant differences in fibre areas between Y and O. RET increased type I fibre area in Y from baseline at both 3 weeks and 6 weeks (baseline: 4509 ± 534 µm2, 3 weeks; 5497 ± 510 µm2P < 0.05, 6 weeks; 5402 ± 352 µm2P < 0.05), whilst O increased from baseline at 6 weeks only (baseline 5120 ± 403 µm2, 3 weeks; 5606 ± 620 µm2, 6 weeks; 6017 ± 482 µm2P < 0.05). However, type II fibre area increased from baseline in Y at both 3 weeks and 6 weeks (baseline: 4949 ± 459 µm2, 3 weeks; 6145 ± 484 µm2 (P < 0.01), 6 weeks; 5992 ± 491 µm2 (P < 0.01), whilst O showed no change (baseline 5210 ± 410 µm2, 3 weeks; 5356 ± 535 µm2 (P = 0.9), 6 weeks; 5857 ± 478 µm2 (P = 0.1). At baseline, there were no differences in fibre myonuclei number between Y and O. RET increased type I fibre myonuclei number from baseline in both Y and O at 3 weeks and 6 weeks with RET (younger: baseline 2.47 ± 0.16, 3 weeks; 3.19 ± 0.16 (P < 0.001), 6 weeks; 3.70 ± 0.29 (P < 0.0001); older: baseline 2.29 ± 0.09, 3 weeks; 3.01 ± 0.09 (P < 0.001), 6 weeks; 3.65 ± 0.18 (P < 0.0001)). Similarly, type II fibre myonuclei number increased from baseline in both Y and O at 3 weeks and 6 weeks (younger: baseline 2.49 ± 0.14, 3 weeks; 3.31 ± 0.21 (P < 0.001), 6 weeks; 3.86 ± 0.29 (P < 0.0001); older: baseline 2.43 ± 0.12, 3 weeks; 3.37 ± 0.12 (P < 0.001), 6 weeks; 3.81 ± 0.15 (P < 0.0001)). DNA synthesis rates %.d−1 exhibited a main effect of training but no age discrimination. Declines in myonuclei addition do not underlie impaired muscle growth capacity in older humans, supporting ribosomal and proteostasis impairments as we have previously reported.
Comparison of Simple-Summated Scoring and Toxicity Index Scoring of Symptom Bother in the NSABP B-30 Clinical Trial
Authors: Hays Ron D. , Gresham Gillian , Ganz Patricia A. , Tighiouart Mourad 
Published: September 2022

Abstract
Background
Level of symptom burden for cancer patients can be summarized using simple-summated scoring of multiple patient-reported symptoms. The Toxicity Index (TI) is an alternative that has been used primarily to summarize clinician-reported toxicities.

Objective
To compare the TI with simple-summated scoring of 28 patient-reported symptoms.

Methods
This is a secondary analysis of longitudinal data from a clinical trial of women with stage 2 or 3 breast cancer: baseline (n = 2156) and 6 months later (n = 1764). Study participants completed the 28-item Breast Cancer Prevention Trial symptom checklist assessing level of symptom bother in the past 7 days and four criterion items assessing general health and overall quality of life.

Results
Associations of simple-summated scoring of the 28 cancer-related symptoms with the general health and overall quality of life items tended to be larger than correlations of the TI summary scoring of the symptoms. For example, the Spearman correlation of change in quality of life was − 0.38 with change in the simple-summated score and − 0.23 with change in the TI.

Conclusion
The findings suggest that simple-summated scoring and differential weighting of the level of symptom bother yield similar results.

Implications for Practice
Clinicians can use simple-summated scoring rather than more complicated scoring algorithms to obtain an indication of overall level of symptom burden among cancer patients.
Periodic unfolding for lattice structures
Authors: Falconi Riccardo , Griso Georges , Orlik Julia 
Published: September 2022

AbstractThis paper deals with the periodic unfolding for sequences defined on one dimensional lattices in $${\mathbb {R}}^N$$

R

N

. In order to transfer the known results of the periodic unfolding in $${\mathbb {R}}^N$$

R

N

to lattices, the investigation of functions defined as interpolation on lattice nodes play the main role. The asymptotic behavior for sequences defined on periodic lattices with information until the first and until the second order derivatives are shown. In the end, a direct application of the results is given by homogenizing a 4th order Dirichlet problem defined on a periodic lattice.
Patients’ Preference for Participation in Medical Decision-Making: Secondary Analysis of the BEDSIDE-OUTSIDE Trial
Authors: Becker Christoph , Gross Sebastian , Gamp Martina , Beck Katharina , Amacher Simon A. , Mueller Jonas , Bohren Chantal , Blatter René , Schaefert Rainer , Schuetz Philipp , Leuppi Joerg , Bassetti Stefano , Hunziker Sabina 
Published: September 2022

Abstract
Background
Patients may prefer different levels of involvement in decision-making regarding their medical care which may influence their medical knowledge.

Objective
We investigated associations of patients’ decisional control preference (DCP) with their medical knowledge, ward round performance measures (e.g., duration, occurrence of sensitive topics), and perceived quality of care measures (e.g., trust in the healthcare team, satisfaction with hospital stay).

Design
This is a secondary analysis of a randomized controlled multicenter trial conducted between 2017 and 2019 at 3 Swiss teaching hospitals.

Participants
Adult patients that were hospitalized for inpatient care.

Main Measures
The primary outcome was patients’ subjective average knowledge of their medical care (rated on a visual analog scale from 0 to 100). We classified patients as active, collaborative, and passive according to the Control Preference Scale. Data collection was performed before, during, and after the ward round.

Key Results
Among the 761 included patients, those with a passive DCP had a similar subjective average (mean ± SD) knowledge (81.3 ± 19.4 points) compared to patients with a collaborative DCP (78.7 ± 20.3 points) and active DCP (81.3 ± 21.5 points), p = 0.25. Regarding patients’ trust in physicians and nurses, we found that patients with an active vs. passive DCP reported significantly less trust in physicians (adjusted difference, − 5.08 [95% CI, − 8.69 to − 1.48 points], p = 0.006) and in nurses (adjusted difference, − 3.41 [95% CI, − 6.51 to − 0.31 points], p = 0.031). Also, patients with an active vs. passive DCP were significantly less satisfied with their hospital stay (adjusted difference, − 7.17 [95% CI, − 11.01 to − 3.34 points], p < 0.001).

Conclusion
Patients with active DCP have lower trust in the healthcare team and lower overall satisfaction despite similar perceived medical knowledge. The knowledge of a patient’s DCP may help to individualize patient-centered care. A personalized approach may improve the patient-physician relationship and increase patients’ satisfaction with medical care.

Trial Registration
ClinicalTrials.gov (NCT03210987).
Exclusivity strategies for digital products across digital and physical markets
Authors: Seifert Rouven , Otten Cord , Clement Michel , Albers Sönke , Kleinen Ole 
Published: September 2022

AbstractDigital technologies allow versioning a product (e.g., a movie) for different physical and digital sequential distribution channels to target heterogeneous consumer segments, thereby creating exclusive offers. Extant literature on sequential distribution for movies largely concentrates on the theater-to-home-video window length (e.g., DVD), thus, neglecting digital distribution channels, particularly the potential of exclusive digital offers when multiple subsequent home video channels are available. We empirically examine the impact of exclusive digital movie offers on demand in digital and physical distribution channels. We fit a system of equations to a unique sample of 260 movies distributed in theaters, digital purchases, digital rentals, and physical purchases channels. Overall, the results indicate substantial profits from exclusive offers. Rather than sales cannibalizations, we find positive cross-channel demand spillovers from exclusive digital offers to delayed physical purchases. Exclusive home video offers outperform mere reductions in the theatrical exclusivity period; thus, implementing exclusive digital home video releases is a promising alternative to avoid conflict-prone reductions of the overall theater-to-home-video release window. Our findings are also relevant to industries that use different online and offline release windows (book publishers) or give exclusive access across different platforms (game publishers).
How executive incentive design affects risk-taking: a literature review
Authors: Kreilkamp Niklas , Matanovic Sascha , Schmidt Maximilian , Wöhrmann Arnt 
Published: September 2022

AbstractThis paper presents a review of research regarding the effects of monetary executive incentives on risk-taking. More precisely, we investigate executives’ risk-taking (i) in response to the curvature (steepness, convexity, concavity) of the compensation function and (ii) with regard to reference points. Thereby, we refine and update common textbook knowledge. In this vein, we identify essential moderators at the personal, firm, or environmental level that can be used to assess the effectiveness of the incentive scheme in a specific context. Implications for incentive system design in practice and paths for future research are discussed.
The Clinical Importance of Differentiating Monogenic Familial Hypercholesterolemia from Polygenic Hypercholesterolemia
Authors: Tandirerung Fistra Janrio 
Published: September 2022

Abstract
Purpose of Review
The current review discusses the importance and significance of differentiating monogenic familial hypercholesterolemia (FH) from polygenic hypercholesterolemia for clinical purpose.

Recent Findings
Consistent scientific evidence have demonstrated that, compared to polygenic hypercholesterolemia, monogenic FH patients are at significantly higher risk for premature coronary heart disease (CHD). This is despite both disease entities having a comparable low-density-lipoprotein cholesterol (LDLC) level. Monogenic FH also has poorer therapeutic response compared to its polygenic counterpart. However, there are no current available clinical management guidelines that stratify hypercholesterolemia patients based on genotype.

Summary
Monogenic FH patients are at higher risk for CHD with poorer therapeutic response. Thus, genotype testing should be performed when available. There is also an urgency to develop genotype-based clinical guideline that stratify patients on genotype and not only based on traditionally known cardiovascular risk factors.
Can the internet mitigate the negative effect of widowhood on Quality of Life? A gender analysis
Authors: Silva Patrícia , Gonçalves Raquel , Magalhães Ricardina , Delerue Matos Alice 
Published: September 2022

AbstractWidowhood often reduces the Quality of Life of individuals of advanced ages by negatively affecting their social network ties. Yet conversely, the Internet has also created new opportunities for communication and interaction, thus contributing to improved Quality of Life. This research analyses the role of the Internet in the relationship between widowhood and Quality of Life from a gender perspective.This study focuses on 31,814 individuals aged 65 or over residing in 17 European countries who participated in Wave 6 of SHARE – the Survey of Health, Ageing and Retirement in Europe.The linear regression analyses highlighted that the role of the Internet in the relationship between widowhood and Quality of Life varies according to gender. More specifically, in Europe, the Quality of Life for widowed women aged 65+ using the Internet is .414 higher (CI=.006 to .0822) than widows who do not use the Internet and married women or women in a de facto relationship whether or not they use the Internet. The results have relevant implications for the development of social policies and suggest a need to develop digital inclusion projects targeting older people, particularly widows, to help promote their Quality of Life.
Backbone and side-chain resonance assignments of the NISTmAb-scFv and antigen-binding study
Authors: Ghasriani Houman , Ahmadi Sara , Hodgson Derek J. , Aubin Yves 
Published: September 2022

AbstractMonoclonal antibodies (mAbs) therapeutics are the largest and fastest growing class of biologic drugs, amongst which, the vast majority are immunoglobulin G1 (IgG1). Their antigen binding abilities are used for the treatment of immunologic diseases, cancer therapy, reversal of drug effects, and targeting viruses and bacteria. The high importance of therapeutic mAbs and their derivatives has called for the generation of well-characterized standards for method development and calibration. One such standard, the NISTmAb RM 8621 based on the antibody motavizumab, has been developed by the National Institute of Standards and Technologies (NIST) in the US. Here, we present the resonance assignment of the single chain variable fragment, NISTmAb-scFv, that was engineered by linking the variable domains of the heavy and light chains of the NISTmAb. Also, addition of a peptide, corresponding to the target antigen of motavizumab, to samples of NISTmAb-scFv has induced chemical shift perturbations on residues lining the antigen binding interface thereby indicating proper folding of the NISTmAb-scFv.
Mogamulizumab for post-transplant relapse of adult T-cell leukemia/lymphoma: a case study
Authors: Hirosawa Makoto , Goto Midori , Oku Masahiko , Akao Kenichi , Kitamura Noriaki , Nakanishi Tsukasa , Tanaka Aya , Niino Daisuke , Higashi Takehiro , Morimoto Hiroaki , Tsukada Junichi 
Published: September 2022

AbstractMogamulizumab (MOG), a humanized monoclonal anti-CCR4 antibody, exerts strong antibody-dependent cellular cytotoxic effects on CCR4-positive adult T-cell leukemia/lymphoma (ATLL) cells. As CCR4 is highly expressed on regulatory T cells as well as ATLL cells, pre-transplant MOG induces severe graft-versus-host disease (GvHD). However, limited data are available on post-transplant use of MOG for relapsed ATLL. Here we describe the case of a patient with ATLL who experienced post-transplant relapse with involvement of peripheral blood, skin, lungs, and lymph nodes. Neither tacrolimus dose reduction nor cytotoxic chemotherapy was effective, but a single dose of MOG (1 mg/kg) induced complete remission. After treatment with MOG, leukemic cells in the peripheral blood rapidly disappeared, and the skin, lymph node, and lung lesions gradually regressed. Most notably, the long-term remission was accompanied by recurrence of moderate acute GvHD (grade II, skin stage 2, gut stage 1, liver stage 0). Our findings indicate that MOG can augment allogeneic immune-mediated anti-tumor reactions through graft-versus-ATLL (GvATLL) even during post-transplant relapse involving the lymph nodes and lungs, along with inducing GvHD.
Thermocapillary-enhanced Melting of Different Phase-change Materials in Microgravity
Authors: García-Acosta Nathaly , Salgado Sánchez Pablo , Jiménez Jaime , Martínez Úrsula , Ezquerro Jose Miguel 
Published: September 2022

AbstractA numerical analysis of the thermocapillary-driven melting of phase change materials (PCMs) in weightlessness is presented. The phase change is explored for different PCMs with moderate melting temperatures, due to their potential for thermal control in space applications. We consider three different alkanes — n-octadecane, n-nonadecane, and n-eicosane — and gallium. Results are discussed in terms of the dimensionless Stefan (Ste) and Marangoni (Ma) numbers, which quantify the importance of the latent heat and the thermocapillary effect during the phase change process, respectively, and the container aspect ratio $$\Gamma$$
Γ
. For alkanes, similar results are obtained with melting rate enhancements that depend on $$\Gamma$$
Γ
. In short (deep) containers, the thermocapillary effect accelerates melting — with respect to the conduction-driven case — by a factor of as much as 4 depending on Ma, while in large (shallow) containers, this enhancement factor can take values up to 20. The best performance is featured by n-eicosane, followed closely by n-octadecane. For gallium, results differ substantially due to its high thermal diffusivity, leading to a significant reduction of the enhancement up to a value of approximately 1.2 at large Ma and $$\Gamma$$
Γ
.
Visuomotor Adaptation Deficits in Patients with Essential Tremor
Authors: Bindel Laura , Mühlberg Christoph , Pfeiffer Victoria , Nitschke Matthias , Müller Annekatrin , Wegscheider Mirko , Rumpf Jost-Julian , Zeuner Kirsten E. , Becktepe Jos S. , Welzel Julius , Güthe Miriam , Classen Joseph , Tzvi Elinor 
Published: September 2022

AbstractEssential tremor (ET) is a progressive movement disorder whose pathophysiology is not fully understood. Current evidence supports the view that the cerebellum is critically involved in the genesis of the tremor in ET. However, it is still unknown whether cerebellar dysfunction affects not only the control of current movements but also the prediction of future movements through dynamic adaptation toward a changed environment. Here, we tested the capacity of 28 patients with ET to adapt in a visuomotor adaptation task known to depend on intact cerebellar function. We found specific impairments in that task compared to age-matched healthy controls. Adaptation to the visual perturbation was disrupted in ET patients, while de-adaptation, the phase after abrupt removal of the perturbation, developed similarly to control subjects. Baseline tremor-independent motor performance was as well similar to healthy controls, indicating that adaptation deficits in ET patients were not rooted in an inability to perform goal-directed movements. There was no association between clinical severity scores of ET and early visuomotor adaptation abilities. These results provide further evidence that the cerebellum is dysfunctional in ET.
Petrogenesis of ilmenite-bearing mafic intrusions: A case study of Abu Ghalaga area, South Eastern Desert, Egypt
Authors: Saleh Gehad M. , Khaleal Farrage M. , Lasheen El Saeed R. 
Published: September 2022

AbstractNeoproterozoic Abu Ghalaga ilmenite-bearing mafic rocks were subjected to geological, petrographical and geochemical studies integrated with mineral chemistry of ilmenite, pyrite and magnetite in order to deduce their petrogenesis. Abu Ghalaga mafic intrusions hosting the largest ilmenite reserve in the Egyptian part of the Arabian-Nubian Shield. Field observations revealed that the intrusions impound ilmenite ore, which occurs as interlayer of massive bands or disseminated within gabbroic rocks. Petrographically, Abu Ghalaga mafic intrusions include different kinds of gabbro; olivine pyroxene gabbro, pyroxene gabbro, pyroxene hornblende gabbro, altered gabbro and Fe-Ti-rich gabbro. They have calc-alkaline to tholeiitic magmas, which are depleted in high field strength elements (e.g., Ta, Nb and Th) relative to low field strength elements (e.g., Ba, Sr and Rb), and exhibit light rare earth elements enrichment relative to heavy rare earth elements with positive Eu anomaly (Eu/Eu*= 0.8-2.4). Variable mineralogical and wide variation of bulk rock geochemistry are ascribed to fractional crystallization and hydrothermal overprinting. Abu Ghalaga gabbroic rocks are derived from fractional crystallization of depleted mantle magmas that were modified by ascending fluids from subducted slab in volcanic arc setting. Fe-Ti oxides required high oxygen fugacity (ƒO2) and water contents by crystal settling of Ti-rich mantle which is applicable with subduction setting. It can be inferred that Abu Ghalaga mafic rocks are neither related to ophiolite nor to Alaskan type but to one of the layered intrusions hosting Fe-Ti oxides.
Ceratobasidium orchid mycorrhizal fungi reveal intraspecific variation and interaction with different nutrient media in symbiotic germination of Prasophyllum (Orchidaceae)
Authors: Freestone Marc , Linde Celeste , Swarts Nigel , Reiter Noushka 
Published: September 2022

AbstractUnderstanding how nutrient requirements of orchid mycorrhizal fungi (OMF) affect symbiotic germination is essential for the ex situ conservation of threatened orchids and their mycorrhizal symbioses. Yet the influence of isolate-level variation in OMF nutrient preferences on orchid germination is unknown. We tested germination ofPrasophyllum frenchii(Orchidaceae) on 15 different media of varying carbon and macronutrient compositions with threeCeratobasidiumisolates of the same operational taxonomic unit (OTU) as determined with internal transcribed spacer locus sequencing. There was a significant interaction between media and fungal isolate on percentage germination, with each isolate recording its highest percentage germination on different nutrient media (Isolate 9.3: 5.2 ± 1.4% on MOM–S; Isolate 8.2: 5.4 ± 1.1% on MOM + S; Isolate 4.3: 2.2 ± 0.5% on 1.25 g/L wheat bran agar). Across all isolates, germination (percentage germination > 0) occurred more frequently on wheat bran agar media (39.7% of plates) than on oatmeal agar media (6.0% of plates). There was also an effect of media type on aerial hyphal growth behaviour of the OMF isolate. All isolates supported growth through to adult flowering plants. We demonstrated that symbiotic germination ofPrasophyllumis affected by media composition. Further, percentage germination and aerial hyphal growth behaviour differed significantly among OMF isolates of the same OTU. This illustrates that a diversity of functionally significant fungal strains occurs within a single OTU, a previously unknown aspect of OMF research with important ecological and conservation implications.