bluuebunny/crossref_metadata_2025_split huggingface dataset:
The first report of an intercostal hemangioma coexisting with multiple hepatic hemangiomas: a case report and review of the literature
Authors: Li Xiangui , Yang Lin , Zhang Yonghai , Shi Gang , Wen Xing 
Published: May 2022

Abstract
Background
Intercostal hemangioma (IH) is an extremely rare disease, with only 17 cases reported over the past 30 years, and the case of IH coexisting with multiple hepatic hemangiomas (MHHs) has not been reported up to now. IHs appear to be more aggressive than hepatic hemangiomas and are difficult to distinguish from other intercostal tumors.
Case presentation:
we report the first case of an intercostal venous hemangioma (IVH) coexisting with MHHs. The patient was a 58-year-old male who came to our hospital due to long-term and repeated epigastric distention. Plain chest computed tomography (CT) scans revealed two adjacent masses protruding from the left chest wall into the thorax. The nature of the masses remained unclear after enhanced CT scans. We performed video-assisted thoracoscopic surgery to remove the masses. These masses were finally diagnosed as IVHs, based on surgical records, imaging, and pathological findings. In addition, plain abdominal CT scans also indicated the presence of MHHs, this diagnosis was consistent with the patient's two doppler ultrasound findings over the last two years. There was no significant change in the hepatic masses when examined at 32 months follow-up. Unfortunately, there was a recurrence of the left IH, and the 5th rib was slightly eroded and destroyed. This may have been related to the fact that we did not distinguish the nature of the masses before surgery and the incomplete removal of masses during surgery.
Conclusions
Early clinical intervention for IHs of the chest wall can prevent tumor growth and damage to adjacent structures. Preoperative imaging diagnosis is important. Hemangiomas have a high recurrence rate, Complete surgical resection is the common treatment, and chest wall reconstruction can be performed if necessary. The authors hope that our case analysis and literature review will help clinicians identify IVH as highly unusual.
Study of quality of sleep in patients with psychiatric illness under remission in relation to quality of life and functional disability
Authors: Yella Siva Anoop , Reddy Ramasubba , Gupta P. C. B. 
Published: May 2022

Sleep is one of the essential biological rhythms of a human being. Sleep disturbances could precipitate psychiatric illnesses like schizophrenia, bipolar affective disorder, depression, anxiety disorders, substance use disorders, etc. Even when psychiatric disorders are successfully treated, sleep disturbances often fail to remit. The quality of sleep in such patients is badly affected and influences the daytime functioning and impairs the overall quality of life.
The aim of the study. To study quality of sleep of patients with psychiatric illness under remission in relation to quality of life and functional disability.
Material and methods. Patients attending the review outpatient department of Tertiary hospital are selected for the study. Patients diagnosed with bipolar affective disorder and schizophrenia according to ICD-10 criteria were taken. Patients meeting remission criteria for bipolar affective disorder i.e., YMRS score </=8, MADRS score </=10 and for schizophrenia –eight PANSS signs and symptoms score <3 are selected from them. Quality of sleep is compared with quality of life and functional disability.
Results: Mean age was found to be 36.59. Mean PSQI score is 8.35. The mean score of physical quality of life domain is 58.28, mean score of psychological quality of life domain is 56.63, mean score of social quality of life domain is 55.39, and mean score of environmental quality of life domain is 55.41. Mean score of functional disability score is 30.14.
Conclusion: Poor quality of sleep in Schizophrenia and BPAD needs to be addressed.
Non-Magmatic Glasses
Authors: Cicconi Maria Rita , McCloy John S. , Neuville Daniel R. 
Published: May 2022

OVERVIEWOn Earth, natural glasses are typically produced by rapid cooling of melts, and as in the case of minerals and rocks, natural glasses can provide key information on the evolution of the Earth. However, natural glasses are products not solely terrestrial, and different formation mechanisms give rise to a variety of natural amorphous materials. In this chapter, we provide an overview of the different natural glasses of non-magmatic origin and on their formation mechanisms. We focus on natural glasses formed by mechanisms other than magmatic activity and included are metamorphic glasses and glasses produced from highly energetic events (shock metamorphism). The study of these materials has strong repercussions on planetary surface processes, paleogeography/paleoecology, and even on the origin of life.
Um olhar sobre as principais reivindicações nos espaços de debates internacionais e nacionais em torno da educação de jovens e adultos
Authors: Belizario Maria Rutimar de Jesus , Mourão Arminda Rachel Botelho 
Published: May 2022

O artigo apresenta espaços de diálogos e debates estabelecidos em torno da temática Educação de Jovens e Adultos (EJA) no âmbito de eventos internacionais e brasileiros. De abordagem qualitativa traz, como base de análise, os documentos preparatórios e finais da Conferência Internacional de Educação de Adultos (CONFINTEA) e da Conferência Nacional de Educação (CONAE), que tiveram lugar no Brasil nas duas primeiras décadas deste século XXI. Os resultados da análise apresentam as reivindicações focalizadas para a educação das pessoas jovens e adultas num quadro em que os espaços de diálogos, debates e reivindicações tornam-se importantes campos de luta nos processos de participação e formulação das políticas públicas de EJA. É, portanto, crucial que esses espaços resultem em ações que articulem o ato de exigir a efetivação do direito à educação com o de contribuir para o planejamento, desenvolvimento e avaliação das políticas públicas de EJA.
A constituição do ser social e a relação homem x natureza
Authors: Junior João Batista de Souza , Fonseca Ricardo Lopes , Minasi Luís Fernando 
Published: May 2022

O homem é dependente dos recursos naturais, assim, para garantir sua existência, necessita agir sobre a natureza. Neste contexto, o presente trabalho tem como objetivo sintetizar o percurso ontológico de constituição do ser social a partir dos capítulos “O trabalho” e “A Reprodução” da obra “Para uma ontologia do ser social II”, de György Lukács, e estrutura-se em três seções: “as esferas basilares: o ser inorgânico e o ser orgânico”, “o trabalho como gênese do ser social” e “a efeito de conclusão: a relação homem x natureza no processo de formação do ser social”. A partir deste trabalho, pode-se compreender que a constituição do ser social se dá a partir do trabalho, estabelecendo uma relação de dependência ontológica com as esferas de base inorgânica e orgânica, que perpassam e influenciam a relação homem x natureza e, consequentemente, as interações sociais.
Práxis docente com leitura literária
Authors: Klem Suelen Cristina dos Santos , Sanches Gislaine Gomes Granado , Balça Ângela Maria Franco Martins Coelho de Paiva , Franco Sandra Aparecida Pires 
Published: May 2022

O artigo resulta de um trabalho realizado junto à disciplina de Educação, formação humana e práxis: implicações da Teoria Histórico-Cultural e da Pedagogia Histórico-Crítica para a Educação Escolar, do Programa de Pós-Graduação, nível de Mestrado em Educação, da Universidade Estadual de Londrina (UEL). O objetivo foi apresentar contribuições das práticas docentes em âmbito escolar, com vistas ao desenvolvimento humano e social a partir do trabalho com a Leitura Literária. Teve por base o problema: como a Leitura Literária pode contribuir para a práxis docente e para o desenvolvimento e a emancipação humana do estudante? Trata-se de uma abordagem crítico-dialética com tratamento de dados qualitativos. A geração de dados consistiu na realização de pesquisa bibliográfica. Como resultados e discussões entendemos que a práxis docente quando planejada intencionalmente proporciona o desenvolvimento e a emancipação humana, pois a Leitura Literária possui contribuições em relação à linguagem, à criticidade e à consciência do leitor.
ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors
Authors: Wu Yinxin , Chen Jinlan , Tan Fangshun , Wang Bei , Xu Wen , Yuan Chengfu 
Published: May 2022

Abstract:Integrins are a class of cell surface adhesion molecules composed of α subunit (ITGA) and β subunit (ITGB). They belong to heterodimer transmembrane glycoproteins. Their main function in organisms is as the receptor of cell adhesion molecules (CAMs) and extracellular matrix (ECM). According to the current research integration analysis, integrin α9 (ITGA9) is one of the integrin subunits, and there are few studies on ITGA9 among integrins. ITGA9 can improve cell migration and regulate various cellular biological functions, such as tumor cell proliferation, adhesion, invasion, and angiogenesis. However, its abnormal expression mechanism in cancer and its specific role in tumor growth and metastasis are still unknown to a great extent. This review reveals the role of ITGA9 in the complex pathogenesis of many tumors and cancers, providing a new direction for the treatment of tumors and cancers. Relevant studies were retrieved and collected through the PubMed system. After determining ITGA9 as the research object, we found a close relationship between ITGA9 and tumorigenesis by analyzing the research articles on ITGA9 in the PubMed system in the last 15 years and further determined the references mainly based on the influencing factors of the articles. Thus, the role of ITGA9 in tumor and cancer genesis, proliferation, and metastasis was reviewed and analyzed. ITGA9 is an integrin subunit, which has been proved to be abnormally expressed in many tumors. After sorting and analyzing the research data, it was found that the abnormal expression of ITGA9 in a variety of tumors, including glioblastoma, rhabdomyosarcoma, melanoma, hepatocellular carcinoma, nasopharyngeal carcinoma, multiple myeloma, non-small cell lung cancer, and prostate cancer, was closely related to the proliferation, metastasis, adhesion, and angiogenesis of tumor cells. These results suggest that ITGA9 plays an important role in the occurrence and development of tumors. The integrin subunit ITGA9 may serve as a biomarker for the diagnosis of tumors and a potential therapeutic target for anti-tumor therapies.
Design, Synthesis and Biological Evaluation of Novel 1, 3, 4-Oxadiazole PD176252
Analogues as Potential GRPR Inhibitors
Authors: Zhu Yuting , Wang Huai , Yu Mingjun , Li Chao , Meng Xiaoming , He Meng , Yao Risheng 
Published: May 2022

Background:
GRPR is over-expressed in cancer cells and is a potential drug target for the treatment of
cancer. PD176252, as the most representative non-peptide inhibitor of GRPR, can inhibit the growth of cancer cells,
but its low selectivity to cancer cells and normal cells limits its further application.

Objective:
The aim of this study was to design and synthesize novel GRPR inhibitor with stronger anti-cancer activity
and higher affinity with GRPR than the lead compound PD176252.

Methods:
A series of 1, 3, 4-oxadiazole derivatives as PD176252 analogues (4a-4j, 6a-6q) were synthesized and their
cytotoxic activity was investigated on four cancer lines with high expression of GRPR (gastric (HGC-27), colon (HCT-
116), prostate (PC-3), and lung (A549)) and one human cell line (gastric mucosal epithelial (GES-1)) by MTT assay.
Flow cytometry analysis and Western Blot were used to determine whether the compound induced programmed apoptosis
of cancer cells. Competitive binding experiment was used to verify the affinity between GRPR and the optimal
compound.

Results:
Compound 6m exhibited significant growth inhibition on all tested cancer cell lines, especially gastric cancer
cells (HGC-27 cellular IC50 0.37 ± 0.04μM). Also, the selectivity of 6m to HGC-27 was much higher than that of
PD176252. Flow cytometric analysis and Western Blot proved that 6m significantly promoted the apoptosis of HGC-
27 cells. Moreover, competitive binding experiment confirmed the close binding of 6m with GRPR, which indicated
6m with a higher affinity than lead compound PD176252.

Conclusion:
Our results suggested that 6m, as a novel GRPR inhibitor, had a higher affinity with GRPR and potential
anti-cancer effect than PD176252, which can be used as a template for further optimization.
Evaluation of In-Vitro Antioxidant Potential and Antimicrobial Activity of
Nephrolepis biserrata (sw.) Schott. Leaf Extracts
Authors: Singh Sonia 
Published: May 2022

Objective:
This study aims to determine the in vitro antioxidant and antimicrobial
properties of Nephrolepis biserrata (Sw.) Schott leaf extracts against different microbial strains,
including 4 gram-positive bacteria, 4 gram-negative bacteria, 3 yeast, and 4 mould.

Methods:
The agar well diffusion method examined the antimicrobial activity of Nephrolepis
biserrata leaf extracts against test micro-organisms. Additionally, TPC (total phenolic content),
TFC (total flavonoid content), and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay of
extracts were determined.

Results:
Preliminary phytochemical screening of all three extracts revealed the presence of tannins,
terpenoids, alkaloids, saponin glycosides, and flavonoids. Results obtained were compared with the
antibiotics Amphotericin B, Fluconazole, and Gentamicin used as standards. The mean zones of
inhibition of methanol extract varied from 7 to 25 mm. However, with petroleum ether extract, the
range varied from 9 to 12 mm and with acetone extract, the range was from 8 to 13 mm at two
different concentrations of 250 and 500μg/disc. All extracts possessed significant antimicrobial
activity against bacterial strains including Bacillus cereus, B. subtilis, Staphylococcus aureus, S.
epidermis, Pseudomonas aeuginosa, Escherichia coli, Proteus Vulgaris, and Klebsiella pneumonia
compared to fungal microbes such as Cryptococcus luteolus, Candida albicans, C. tropicalis,
Aspergillus candidus, A. niger, and Mucor hiemalis wehmer, respectively. However, amongst all
the three extracts, methanol leaf extract showed maximum antimicrobial activity.

Conclusion:
From the present study, it has been summarized that the antimicrobial activity of
plants might be due to the presence of flavonoids and tannin components. In conclusion, still
advanced research is required to isolate the active principles from plant extracts, showing
antimicrobial activity that may lead to the development of a phytomedicine.
Antibacterial Activity of Pulicaria odora Leaf Phenolics Collected in
Algeria
Authors: Touati Naima , Saidani Karima , Hassaini Yasmina , Kasri Amel , Bedjou Fatiha 
Published: May 2022

Background:
Pulicaria is a genus of the Asteraceae family, tribe Inuleae, containing 100
species with a distribution from Europe to North Africa to Asia.

Objective:
In this work, the study is focused on the difference in phytochemical and antibacterial activity of Pulicaria odora harvested in two regions of northern Algeria.

Methods:
Two maceration extraction methods were used; a stir plate at room temperature and bath
shaker at 37 °C. Total phenolics and flavonoids were carried out using Folin-Ciocalteu and aluminium
chloride methods, respectively. Antibacterial activity was evaluated by agar diffusion method on four
bacterial strains Listeria innocua, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.

Results:
The results found showed that the highest total polyphenol content was 271,8 ± 22, 52 mg
gallic acid equivalent/g dry matter (mg GAE/g of DM); the best flavonoid content is 51,53 ± 4,42 mg
quercetin equivalent / g of dry matter (mg QE/g of DM) harvested in Bejaia. The best levels of total
polyphenols and flavonoids from the plant harvested in the region of Tizi-Ouzou are 218,23 ± 12.33
mg GAE / g of DM, 54,15 ± 5,98 mg QE/ g DM respectively. The two phenolic extracts obtained by
the two solvents at a concentration of 70% are more active against S. aureus (17.66 mm for the sample of Bejaia at the concentration of 1mg /20µL), while a moderate sensitivity is recorded against other strains for the two samples.

Conclusion:
Pulicaria odora leaf extract is strong against bacterial infection and can be used as medicinal remedy and in food industry
Computational Study of Treated and Untreated Corn Husk Powder and
Polycaprolactone for Microwave Shielding Using Finite Element Method
Authors: Yakubu Abubakar , Abdullahi Sirajo , Sahabi Suleiman , Sani Garba Danjuma 
Published: May 2022

Introduction:
Microwave devices and communication devices produce electric fields,
which may be dangerous to nearby applications. These fields can be shielded using conductive
shells that are closed on all sides. These close conductive shells are often designed using thin metal
foils. However, for many applications, these enclosures can add significantly high cost and weight
to a product, and a minute gap in the enclosure can completely damage the benefits of the enclosure.
Moreso, the metal foil is not flexible to complex geometry. The solution to the gap identified is to
use a light, flexible and durable material that can shield unwanted electromagnetic (EM) waves. For
this work, treated and untreated corn husk powder (CHP) was produced from agricultural waste residues
by grinding into powder form, while polycaprolactone (PCL) was commercially obtained.

Methods:
The composites of the materials were synthesized using the melt blending technique. The
dielectric property of the produced materials was investigated using the open-ended coaxial probe
technique. Moreover, the dielectric constant values were used in the composites' computational
study using the finite element method.

Results:
Results indicate that the treated dielectric property was greater than the untreated composites.
The alkali treatment affected the value of the dielectric constant, shielding effectiveness, and
transmission coefficients of the composites. The highest dielectric property obtained was 3.42 for
the 30 % filler with a loss factor of 0.47. The filler played a significant role in the values of shielding
effectiveness (SE) obtained, where the highest filler was able to shield radiation by up to -4.21
dB at the frequency range measured.

Conclusion:
The electric field intensity observed that the highest filler had a minimum transmitted
intensity of 2185.87 v/m. The high loss factor of 0.47 obtained for the 30% filler content can produce
waveguide terminators and other microwave components from this composite.
Priority For Strengthening Manpower Institutional Capacity In North Maluku Province
Authors: Jabid Abdullah Wajir , Soamole Bakri , Mustafa Rahman Dano 
Published: May 2022

AbstractThe main problem of employment includes the amount of open unemployment, the low quality of the workforce (low competency), low work productivity, and low welfare of workers, so workforce planning is needed that can be used as a reference by all stakeholders in picking up investments in North Maluku Province. The purpose of this study is to look into the strategy for establishing and expanding workforce competency in various investment priorities in North Maluku Province. The goal is to enhance worker competency in the short and medium term; consequently, the quality of Job Training Centers must be prioritized (JTC). Furthermore, downstreaming agriculture and fisheries is a critical investment priority for preparing its workforce for competence, because it is commensurate with the characteristics and potential of local resources, as well as geographical considerations and sustainability guarantees.Keywords: Employment, competitiveness, investment, inclusive growth, AHPPrioritas Kompetensi Tenaga Kerja Untuk Daya Saing Investasi Di Provinsi Maluku Utara Abstrak Masalah utama ketenagakerjaan diantaranya adalah besarnya pengangguran terbuka, rendahnya kualitas angkatan kerja (kompetensi rendah), rendahnya produktivitas kerja, dan rendahnya kesejahteraan pekerja, sehingga diperlukan perencanaan tenaga kerja yang dapat dijadikan acuan oleh seluruh pemangku kepentingan dalam menjemput investasi di Provinsi Maluku Utara. Tujuan penelitian ini adalah menganalisis strategi mengembangkan dan meningkatkan kompetensi tenaga kerja pada berbagai prioritas pilihan investasi di Provinsi Maluku Utara. Menggunakan metode analisis deskriptif dan Analysis Hierarchy Process (AHP), hasil penelitian ini menunjukkan bahwa prioritas untuk meningkatkan kompetensi tenaga kerja di Maluku Utara dalam jangka pendek dan menengah, perlu memberi perhatian dan prioritas terhadap mutu balai latihan kerja (BLK). Selain itu, prioritas investasi yang sangat urgen untuk dipersiapkan bekal kompetensi tenaga kerjanya adalah hilirisasi pertanian dan perikanan, karena sesuai dengan karakteristik dan potensi sumber daya lokal, aspek geografis serta jaminan keberlanjutan (sustainability). Kata kunci: Ketenagakerjaan, daya saing, investasi, pertumbuhan inklusif, AHP
Rubber Production Projection in Riau Province using Autoregressive Integrated Moving Average (ARIMA) Approach
Authors: Zuhdi Fadhlan , Anggraini Rizqi Sari , Yusuf Rachmiwati 
Published: May 2022

AbstractRubber has long been become a mainstay of Indonesian exports along with oil palm, coffee and tea. As a commodity that has increasing world demand, rubber exports are given priority. This must be responded quickly by the government in order to increase national income from the export side. Riau as the third largest national rubber producer has great potential to increase rubber production. Therefore, it is necessary to make further analysis related the targets that need to be achieved, so the development of rubber production can be applied measuredly. Analysis using the ARIMA method is used to predict rubber production in the next five years (2021-2025). The results of the analysis showed that there will be an increase in rubber production by 2.38 percent with a maximum increase up to 3.05 percent. This increase is still at a low level, so efforts need to be made to increase rubber production.Keywords: ARIMA, export, production, projection, rubberProyeksi Produksi Karet di Provinsi Riau dengan Pendekatan Autoregressive Integrated Moving Average (ARIMA)AbstrakKaret telah sejak lama menjadi produk andalan ekspor Indonesia bersama dengan kelapa sawit, kopi dan teh. Sebagai komoditas yang terus mengalami peningkatan permintaan di dunia menyebabkan ekspor karet menjadi sebuah keuntungan. Hal tersebut harus dapat direspon dengan cepat oleh pemerintah guna meningkatkan pendapatan nasional dari sisi ekspor sehingga dapat meningkatkan perekonomian dalam negeri. Provinsi Riau sebagai provinsi yang memiliki kontribusi terbesar ketiga sebagai produsen karet nasional memiliki potensi yang besar untuk dapat meningkatkan produksi karet. Oleh sebab itu, perlu adanya analisis lebih lanjut terkait dengan target yang perlu dicapai agar pengembangan produksi karet dapat diaplikasikan secara terukur. Analisis dengan metode ARIMA digunakan untuk memproyeksikan produksi karet lima tahun mendatang (2021-2025). Hasil analisis menunjukkan bahwa akan terjadi peningkatan produksi karet sebesar 2.38 persen dengan peningkatan maksimum mencapai 3.05 persen. Kenaikan tersebut masih berada pada taraf yang rendah sehingga perlu dilakukan upaya agar terjadi peningkatan produksi karet.Kata kunci: ARIMA, karet, ekspor, produksi, proyeksi