bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of antiplatelet therapy with P2Y12 receptor inhibitors in patients with myocardial infarction according to the Russian Register of Acute Myocardial Infarction REGION-MI
Authors: Boytsov S. A. , Shakhnovich R. M. , Tereschenko S. N. , Erlikh A. D. , Kukava N. G. , Pevsner D. V. , Rytova Yu. K. 
Published: October 2022

Aim To study specific features of administering platelet P2Y12 receptor inhibitors to patients with myocardial infarction (MI) in real-life clinical practice; to reveal a possible inconsistency of the therapy with clinical guidelines; to evaluate the patients’ compliance with the medication at the outpatient stage; and to outline major direction for improving quality of the antiplatelet treatment.Material and methods REGION-MI is a multicenter prospective, observational study. The observational period is divided into 3 stages: during the stay in the hospital and at 3 and 12 months following the inclusion into the registry. Information about the drug therapy (used at the time of hospitalization, administered before the hospitalization, received in the hospital, and prescribed at discharge from the hospital) was recorded in the patient’s individual registration card. Information about the antiplatelet treatment at 6 months following enrollment into the study was obtain by phone.Results The study included 4 553 patients. Dual antiplatelet therapy was administered after MI to 94.4 % patients: clopidogrel was administered to 52 %, ticagrelor to 42.2 %, and prasugrel to 11 patients (0.2 %). Ticagrelor was administered significantly more frequently in ST segment elevation myocardial infarction (STEMI) than in NSTEMI, 45 % and 33 %, respectively (p<0.001); clopidogrel was also administered more frequently to patients with STEMI than with NSTEMI, 59 % and 50 %, respectively. According to ARC-HBR criteria, in MI and a high risk of bleeding, clopidogrel was administered more frequently than ticagrelor (p <0.001). Ticagrelor was significantly more frequently administered to patients with MI and a low risk of bleeding than to patients with a high risk (p<0.001). In STEMI and a low risk of bleeding, ticagrelor was administered somewhat more frequently than clopidogrel, 56 % and 44 %, respectively (р<0.05). In NSTEMI and a low risk of bleeding, clopidogrel was administered more frequently than ticagrelor, 53 % and 47 %, respectively (p<0.05). At 6 months post-MI, 94 % of patients continued taking one of the P2Y12 inhibitors.Conclusion According to data of the REGION-MI registry, the frequency of administering P2Y12 inhibitors to patients with acute MI was high, and the patients’ compliance with this therapy was high at 6 months following MI. Although ticagrelor (the most available drug of all powerful platelet P2Y12 receptor inhibitors) has been prescribed more frequently in the recent years, a definite reserve exists for increasing the frequency of its administration. This is particularly important with a low risk of bleeding and the absence of requirement for anticoagulants. Thus, the prognosis for MI patients can be considerably improved.
Cognizance and awareness of COVID-19 virus amongst the non-teaching staff at health care center- A cross sectional study
Authors: Sachdeva Shivani , Dave Kajal , Saluja Harish 
Published: October 2022

COVID-19 (Coronavirus disease 2019) was declared a “pandemic” by the World Health Organization (WHO) in early March 2020. All over the world extraordinary measures are being adopted to fight the spread of the ongoing outbreak. Under such conditions, people’s knowledge to preventive measures is greatly affected by their awareness of the disease. Aim of the present study was to assess the awareness and knowledge about Covid-19 among non-treating staff in hospitals. The community-based, cross-sectional survey was conducted using a self-developed structured questionnaire and individuals were personally interviewed. A total of 82 individuals were interviewed who included the sterilization workers, cleaners and ward staff. The non-teaching staff included was working in the dental, medical and physiotherapy institute. The result interpretation showed that 95.1% of participants included in the study knew about Covid-19. Awareness was pragmatic among 89% about the precautions to be taken. While, 63.4% agreed on getting formal training from the workplace. Respondents agreed to change the methods and adopt newer techniques to bout with the Covid-19 pandemic. Since its initial outbreak in China in December 2019, the COVID-19 disease has had a cascading effect worldwide. Even though these subjects are not actively involved in patient management, there are high chances of non-clinical staff having patient contact at some point in the healthcare setting and therefore at risk of contracting and spreading the infection.
My Generation of the 1960s
Authors: Pruzhinin B.I. 
Published: October 2022

The author of the article tries to clarify the peculiarities of the views of the generation of philosophers of the sixties, based on his personal experience. According to the author, the worldview and personal characteristics of this generation are based on the experience and understanding of the events of the national history of the 1950s, associated with the exposure of the personality cult of Stalin, and the phenomenon of the thaw. These events allowed the generation of the sixties to form a worldview based on a rethinking of their views, first – spiritual independence.
Performance of Green Gram Varieties under Organic Production System
Authors: Lal G. , Lal S. , Chaudhary N. , Choudhary M.K. , Meena S.S. , Kumar N. 
Published: October 2022

Background: Indiscriminate use of chemical fertilizers causes’ harmful impact on soil, environment and human being, hence demand of organic food products has shot up recently. Organic farming aims to optimization of crop productivity rather than its maximization through renewal and strengthening of ecological processes and functions of whole ecosystem. Limited varieties information is available on long term performance of pulse crop varieties under organic cultivation system so far. Therefore, this experiment was conducted to investigate the growth and yield performance of green gram varieties under organic production system. Methods: Eight varieties of green gram were studied under organic production system. Experiment was laid out in randomized block design with three replications. The recommended dose of nutrients for green gram is 15:40:00 kg ha-1 and manures were applied on nitrogen equivalent basis through organic sources. The observations on growth and yield parameters of green gram were recorded at the time of harvesting. Soil and plant samples were collected at time of harvest and analyzed for available nutrients in soil and nutrient content in seed samples. Result: The maximum plant height at harvest (62.47cm), number of primary branches per plant (5.18), number of pods per plant (27.27), number of seeds per pod (11.27) with highest seed yield (809.80 kg ha-1) exhibited by variety MUM-2 followed by RMG-975 (802.47 kg ha-1) and lowest seed yield (617.80 kg ha-1) was found in the variety MSG-118. MUM-2 variety recorded highest plant nutrient status as compared to other varieties. Among eight varieties of green gram MUM-2 and RMG-975 found better for organic farming in terms of growth, seed yield and quality aspects.
Integration of life skills into basic student basketball training program for positive youth development
Authors: Suardika I Kadek , Ma'mun Amung , Kusmaedi Nurlan , Budiana Dian , Mile Sarjan , Purnomo Eko 
Published: October 2022

Sports is an excellent way to increase many important values in life (including developing positive youth). This study aims to improve and develop positive youth development through the life skills programme that has been prepared. This study uses a quantitative method with a pre-test–post-test control group design approach. In this study, the researcher used a sampling technique, namely purposive sampling, with a total of 30 students aged 11–12 years. Then, the group was divided into three, namely (1) groups with basketball practice and integrated with life skills; (2) groups with basketball practice but not integrated with life skills; and (3) groups without basketball practice and also without integrating life skills. The test instrument uses the Life Skills for Sport Scale. The results of the study show that group A is better than groups B and C. These results have implications for the trainers to be able to incorporate life skills into the programme designed.

Keywords: Student, basketball, training, life skills, positive youth development
Impacts of formative evaluation model towards improving students’ learning outcomes in online teaching platforms
Authors: Winarno Sri , Rohmani Asih , Senata Denny , Andono Pulung Nurtantio 
Published: October 2022

Education is one of the areas that was affected by the Covid-19 pandemic. In the current situation, lecturers must have the ability to use the appropriate approach in the teaching and learning process. The majority of universities have used online teaching platforms in the teaching and learning process. However, Lecturers have many obstacles in the learning process. One of them is that the lecturer does not know the online-based evaluation platforms. This situation has decreased students’ knowledge. Therefore, innovation of the learning evaluation model is imperative to development. This study discusses the impacts of the Formative Evaluation Model (FEM) in improving students' learning outcomes. FEM is applied in KULINO as a Learning Management System (LMS). A total of 120 students and 2 lecturers were involved in this research. Using two learning approaches; one group used the summative evaluation model while the latter group used the FEM evaluation model. Questionnaires about students’ perceptions were distributed before and after the experimental learning process. There were differences in the mean scores between pre and post-test. The mean score of students’ attitude increased by 6.74 points and students’ knowledge mean score increased by 2.23 points.

Keywords- Education, Formative evaluation model, Learning management system
Students’ response to the implementation of brain-based learning (the BBL) approach in history teaching
Authors: Darmawan Wawan , Fauzi Wildan Insan , Santosa Ayi Budi , Nisa Jakiatin 
Published: October 2022

This study focuses on how students respond to brain-based learning (the BBL) in History teaching to enhance cognitive, social, reflective, emotional, and physical aspects. The study used a survey-based approach and collected data through questionnaires, interviews, and two-month observations of three participating schools. Findings indicate that the teaching-learning process using the BBL approach helps educators understand students’ different characteristics and build a conducive classroom atmosphere that facilitates cooperation, historical reflection, as well as historical fact memorizing skills. However, it appears that this approach has not addressed students’ emotional intelligence, historical empathy, and stress management. Findings show that the students were still anxious when facing a History test involving a vast amount of data that required them to memorize facts even though they had been provided with training on different memorizing techniques. In addition, the students were not guided to express their feelings about a particular historical phenomenon.

Keywords: brain, history, learning, memorizing, textbook.
Mechanical Responses of Underground Unparallel-Fissured Rocks Subjected to Coupled Static-Dynamic Loading
Authors: Du Hongbo , Wang Haoran , Feng Peng , Tian Renjie , Wang Yi 
Published: October 2022

Abstract
Preexisting fissures within a natural rock mass significantly affect the mechanical responses of underground engineering rocks when subjected to coupled static-dynamic loads. Understanding the dynamic mechanical responses of prestressed fissured rocks is beneficial for optimizing the stability of rock engineering structures. Based on the split Hopkinson pressure bar (SHPB) device, a series of coupled static-dynamic compression tests were systematically performed to investigate the mechanical properties, the failure behaviors, the fragment characteristics, and the energy dissipation of unparallel-fissured rocks. Results show that the coupled dynamic strength increases with the applied strain rate for a given static prestress, while the elastic modulus does not exhibit any clear loading rate dependence. Under the given strain rate, the fissured sandstone has the highest strength under the static prestress of 0.6 uniaxial compressive strength (σs), followed by the static prestress of 0.4 σs, 0.2 σs, and 0.8 σs. The failure modes of fissured sandstone highly depend on the dynamic strain rate, and the ultimate failure pattern gradually changes from the mixed tensile-shear failure mode to the shear failure dominant mode with increasing strain rate. With an increasing dynamic strain rate, fissured rocks should absorb more energy in a short time, which results in more crack formation in the failure process. A higher static prestress can induce greater energy dissipation density and energy utilization efficiency when the static prestress is less than 0.8 σs. In addition, the relationships between energy dissipation and mechanical response of fissured sandstones under coupled static-dynamic loads are established and discussed.
Hepatic venous pressure gradient and rebleeding risk of patients with nonalcoholic steatohepatitis cirrhosis after variceal bleeding
Authors: Shi Yiqi , Shen Wenyong , Xu Gang , Wang Xunzheng , Ning Bo 
Published: October 2022

Abstract
Background & Aims
Hepatic venous pressure gradient (HVPG) has a strong predictive value for variceal rebleeding in cirrhotic patients, but the accuracy of an HVPG may be compromised in nonalcoholic steatohepatitis (NASH) cirrhosis. This study aimed to evaluate the accuracy of HVPG and portal pressure gradient (PPG) for predicting rebleeding in NASH cirrhosis after acute variceal bleeding.
Patients and Methods
Thirty-eight NASH cirrhosis patients and 82 hepatitis B virus (HBV) cirrhosis patients with acute variceal bleeding were included in this study. All patients recived transjugular intrahepatic portalsystemic shunt (TIPS). The prognostic value of HVPG and PPG for variceal rebleeding was evaluated.
Results
Compared with HBV cirrhosis, NASH cirrhosis demonstrated a lower portal pressure (26.3 ± 6.1 vs. 30.1 ± 4.7; P <0.001), lower wedge hepatic venous pressure (24.1 ± 5.3 vs. 27.6 ± 5.5; P = 0.001) , lower HVPG (15.3 ± 3.8 vs. 18.0 ± 4.8; P = 0.003) and lower PPG (18.0 ± 3.7 vs. 20.0 ± 3.4; P = 0.005). HVPG (AUC = 0.82; P = 0.002) and PPG (AUC = 0.72;P = 0.027) had promising prognostic value among NASH cirrhosis patients. The optimal threshold of HVPG and PPG for predicting rebleeding in NASH cirrhosis was 17 mmHg and 20 mmHg. At multivariate analysis, an HVPG ≥17 mmHg was a significant predictor of variceal bleeding (HR 9.40; 95% CI 1.85-47.70; P = 0.007).
Conclusions
Patients with NASH cirrhosis had lower HVPG and lower PPG than those with HBV cirrhosis. However, the prevalence of rebleeding was similar between two groups. HVPG measurement is still an accurate way to assess the risk of variceal rebleeding in NASH cirrhosis.
Prevalence, Indications and Fetal Outcome of Operative Vaginal Delivery in Sub-saharan Africa, Systematic Review, and Meta-analysis
Authors: Temesgen Tesfaye , Getnet Addius , Ahimed Abbas , Alemu Asrat , Mebratu Andualem , Figa Zerihun 
Published: October 2022

Abstract
Background
Operative vaginal deliveries are the mode of the deliveries accomplished with either a vacuum device or forceps to the fetal head and outward traction generating a force that augments maternal pushing to deliver the fetus vaginally. As a result, this systematic review and meta-analysis aimed to assess the prevalence, indications, and fetal outcome of operative vaginal delivery in sub-Saharan Africa.
Method
Search for relevant articles was done by using online databases like Google Scholar, PubMed, HINARI and Web of Science, African OnLine, and other gray and online repositories of Universities in Africa. The JOANNA Briggs Institute standard data extraction format was used to extract and appraise high-quality articles before being included in this study. The heterogeneity of the studies was tested by the Cochran Q test and I2 statistical test. The publication bias was tested by a Funnel plot and Egger’s test. The overall pooled prevalence, indications, and fetal outcome of operative vaginal delivery along a 95% CI using forest plots and tables.
Result
The overall pooled prevalence of operative vaginal delivery in sub-Saharan Africa was 7.98% (95% CI; 5.03–10.65; I2 = 99.9%, P < 0.001). The indications of operative vaginal delivery in sub-Saharan African countries include the prolonged second stage of labor 32.81%, non-reassuring fetal heart rate 37.35%, maternal exhaustion 24.81%, big baby 22.37%, maternal cardiac problem 8.75%, and preeclampsia/eclampsia 2.4%. Regarding the fetal outcome, favourable fetal outcomes was 55% (95CI: 26.04, 84.44), p = < 0.56, I2: 99.9%). From those births with unfavorable outcomes, the need for the resuscitation of new-born was highest 28.79% followed by poor 5th minute Apgar score, NICU admission, and fresh stillbirth, 19.92%, 18.8%, and 3.59% respectively.
Conclusion
The overall prevalence of OVD in sub-Saharan Africa was slightly higher compared to other countries. The prolonged second stage of labor (PSSOL), maternal exhaustion, maternal cardiac problem, preeclampsia and eclampsia, fetal asphyxia, and a big baby (> 4000g) were the indications for operative vaginal delivery. Poor 5th minute Apgar score 19.92%, admission to NICU 18.8%, need of the new-born resuscitation 28.78%, and fresh new-born 3.59% were unfavourable fetal outcomes after application of OVD. To reduce increased applications and adverse fetal outcomes of OVD, capacity building for obstetrics care providers and drafting guidelines are required.
Evolution of the Eocene shallow carbonate platform in Tunisia: Carbon isotopes stratigraphy and petroleum implications
Authors: Messaoud Jihede Haj , Thibault Nicolas , Aljahdali Mohammed H. , Yaich Chokri 
Published: October 2022

Abstract

This study aims to comprehend how the SW Neo-Tethys carbonate platform responded to Eocene global warming events and the possible relations with developing the middle Eocene carbonate oil reservoir (Reneiche member). The Eocene deposits of the Southern Neo-Tethys margin (Tunisia) are NW-SE-oriented facies belts with evident variations in thickness and facies. Along a homoclinal ramp, the Cherahil Formation's shallow carbonate platform facies progressively shift into the Souar Formation's globigerinids-clays. Major controls have been exerted on the central Tunisia platform by synsedimentary tectonics, sea-level oscillations, and warming events. Ten facies were identified and are attributed to at least three sedimentary models. The middle-upper Eocene sedimentary environments are wave dominant, influenced by storms and tide in a shallow water depth, passing during the Oligocene into a sandy fluvial and estuarine environment. Sequence stratigraphic analysis points towards shallowing upward trend interrupted during the lower Bartonian by a significant transgression. This sea-level rise coincides with a shift towards a short maximum nummulite carbonate production absent since the nummulitic limestones of the El Garia Formation (Ypresian). Proximal facies of dominant lumachellic marls shift to a thickening-upward sequence of transgressive facies culminating in a maximum nummulitic carbonate production during the middle Eocene transgression and coincides broadly at the global scale with the occurrence of the Middle Eocene Climatic Optimum (MECO). Previous biostratigraphic studies confirm the position of the Reneiche/Siouf member and here by the bulk carbon isotope record (δ13C) characterized by a negative carbon isotope excursion in the middle of the Siouf member followed by a positive excursion at the top of this member, which is comparable to the δ13C record through the MECO in the reference sections. In response to the MECO, the early Bartonian is recognized as crucial for the large benthic foraminifera in various shallow-marine settings along the Tethys margins.
Study on adsorption of NOx/SO₂ with coconut shell activated carbon in simulated flue gas
Authors: Xu Qing , Lu Jianyi , Sun Chenxi 
Published: October 2022

Abstract
Adsorption is used to simultaneously remove SO2 and NOx from flue gas because of its easy operation, low energy consumption and easy practical application. In this paper, coconut shell activated carbon (AC) was used as the adsorption matrix for simultaneous desulfurization and denitrification. The AC was modified and characterized using a physical followed by chemical approach, and orthogonal tests were designed to conduct experiments on the simultaneous adsorption of SO2 and NOx from modified activated carbon in simulated flue gas. The adsorption experiments showed that the modified coconut shell AC had high-performance adsorbent conditions for the simultaneous removal of SO2 and NOx. The optimal modification conditions were as follows: the physical pore size of the AC was adjusted in an air atmosphere at 400°C for 2h, then modified by reduction in 3% KOH solution, followed by impregnation using 6% cerium nitrate solution, respectively. When the minimum concentration of SO2 in flue gas is 1000ppm and the minimum adsorption temperature is 50℃, its average desulfurization and denitrification efficiency can reach more than 95% and 40% respectively. As an excellent adsorbent, coconut shell AC has good application prospects for simultaneous desulfurization and denitrification of flue gas.
Construction of miRNAs and gene expression profiles associated with ischemic cardiomyopathy: Bioinformatics analysis
Authors: Dinh PhongSon , Peng Jun-Hua , Tran ChauMyThanh , Tran ThanhLoan , Pan Shang-Ling 
Published: October 2022

Abstract
Background
Ischemic cardiomyopathy (ICM) has ranked as the most common cause morbidity and mortality in the elderly over the past decades. One of the most important reasons for this is that its exact underlying mechanism remains poorly understood.
Methods
Five datasets were downloaded from the GEO database. Differential gene expression (DGE) was identified by the R RobustRankAggreg package. Differential miRNA expression was evaluated by the Limma package. Gene potential functions were then determined by the clusterProfiler database. The miRNA-DGE regulatory network was predicted by cyTargetLinker. Then, a protein-protein interaction network was constructed by STRING tool, MCODE, and BiNGO tool.
Results
91 miRNAs and 274 potential genes were identified. Of these, COL1A1, IGF1 and CCND1 were found to be involved in many signaling pathways; and miR-9-5p was found to play critical roles in ICM.
Conclusion
Our study has unraveled the potential key genes and miRNAs as well as the possible underlying molecular pathogenesis of ICM, which is a crucial step leading to a new avenue for the early intervention of this disorder.