bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic comparison of pancreatic ductal adenocarcinoma
models identifies a conserved highly plastic basal cell state
Authors: Pitter Kenneth L. , Grbovic-Huezo Olivera , Joost Simon , Singhal Anupriya , Blum Melissa , Wu Katherine , Holm Matilda , Ferrena Alexander , Bhutkar Arjun , Hudson Anna , Lecomte Nicolas , de Stanchina Elisa , Chaligne Ronan , Iacobuzio-Donahue Christine A. , Pe'er Dana , Tammela Tuomas 
Published: August 2022

Abstract
Intra-tumoral heterogeneity and cellular plasticity have emerged as hallmarks of cancer, including pancreatic ductal adenocarcinoma (PDAC). As PDAC portends a dire prognosis, a better understanding of the mechanisms underpinning cellular diversity in PDAC is crucial. Here, we investigated the cellular heterogeneity of PDAC cancer cells across a range of in vitro and in vivo growth conditions using single-cell genomics. Heterogeneity contracted significantly in 2D and 3D cell culture models but was restored upon orthotopic transplantation. Orthotopic transplants reproducibly acquired cell states identified in autochthonous PDAC tumors, including a basal state exhibiting co-expression and co-accessibility of epithelial and mesenchymal genes. Lineage-tracing combined with single-cell transcriptomics revealed that basal cells display high plasticity in situ. This work defines the impact of cellular growth conditions on phenotypic diversity and uncovers a highly plastic cell state with the capacity to facilitate state transitions and promote intra-tumoral heterogeneity in PDAC.
Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts
Authors: Jin Jiajia , Gao Liaomei , Zou Xiuli , Zhang Yun , Zheng Zhijian , Zhang Xinjie , Li Jiaxuan , Tian Zhenyu , Wang Xiaowei , Gu Junfei , Zhang Cheng , Wu Tiejun , Wang Zhe , Zhang Qunye 
Published: August 2022

Background:
Preeclampsia is one of the leading causes of maternal and perinatal morbidity and is characterized by hypertension, inflammation, and placental dysfunction. Gut microbiota plays key roles in inflammation and hypertension. However, its roles and mechanisms in preeclampsia have not been fully elucidated.

Methods:
16S rRNA gene sequencing and targeted metabolomics were conducted on stool samples from 92 preeclamptic patients and 86 normal late-pregnant women. Then, fecal microbiota transplantation and in vitro and in vivo functional experiments were performed to explore the roles and mechanisms of gut microbiota in preeclampsia development.

Results:

We revealed the gut microbiota dysbiosis in preeclamptic patients, including significant reductions in short-chain fatty acid-producing bacteria and short-chain fatty acids. The gut microbiota of preeclamptic patients significantly exacerbated pathologies and symptoms of preeclamptic rats, whereas the gut microbiota of healthy pregnant women had significant protective effects.
Akkermansia muciniphila
, propionate, or butyrate significantly alleviated the symptoms of preeclamptic rats. Mechanistically, they significantly promoted autophagy and M2 polarization of macrophages in placental bed, thereby suppressing inflammation. Propionate also significantly promoted trophoblast invasion, thereby improved spiral arterial remodeling. Additionally, we identified a marker set consisting of
Akkermansia
,
Oscillibacter
, and short-chain fatty acids that could accurately diagnose preeclampsia.

Conclusions:
Our study revealed that gut microbiota dysbiosis is an important etiology of preeclampsia. Gut microbiota and their active metabolites have great potential for the treatment and diagnosis of preeclampsia. Our findings enrich the gut–placenta axis theory and contribute to the development of microecological products for preeclampsia.
Does the UK Home Office Care about the Rule of Law?
Authors: York Sheona 
Published: August 2022

Abstract
The instrumentalisation of law for the purposes of creating a ‘hostile environment’ and deterring ‘unwanted migration’ is particularly visible in the UK. The new Nationality and Borders Act 2022 contains proposals on asylum which show a rejection of international law norms and conventions, without having had the political courage to put that rejection squarely to the public. That is not new. Right from the emergence of asylum as a political issue in the 1980’s, the lukewarm official ‘welcome’ never quite hid the stance of disbelief which underlay the UK’s legal and procedural responses. A parallel process, beginning even earlier but accelerating from 2010 onwards, has taken place in UK domestic immigration law. New legislation, Immigration Rules, policies, application procedures and litigation practices show diminishing respect for rule of law principles. This article uses simple and hopefully uncontroversial definitions of international law norms and accepted common law rule of law principles against which to analyse and critique key aspects of UK immigration control. It concludes that UK policies and practice have over time displayed an increasing hostility to those norms and principles, resorting to ignorant and even brazen indifference to facts, evidence, and analysis, and widening the gap between domestic and international law in important respects.
The UN Disability Rights Convention and EU Fundamental Rights
Authors: Busuttil Nicolette 
Published: August 2022

Abstract
This article examines the role to be played by the UN Convention on the Rights of Persons with Disabilities (CRPD) in the protection of migrants with disabilities within the EU, in view of the apparent invisibility of this population within existing frameworks. It argues that the CRPD’s dual role as a core UN human rights treaty and an international agreement concluded by the EU, which occupies an “integral part” of the EU legal order, interacts with pre-existing (homegrown) sources of fundamental rights obligations within EU law to produce a ‘disability fundamental rights framework’. Accordingly, the CRPD’s substantive protection should act to determine the minimum standard of protection afforded to migrants with disabilities within the EU, without prejudicing the possibility of EU law offering more extensive protection. In so doing, this article demonstrates the emancipatory potential of a ‘disability fundamental rights framework’ vis-à-vis a specific category of (unwanted) migrants and which follows from a principled interpretation of the CRPD’s interaction with EU fundamental rights.
A Murderous Plague: State Hypermasculinity, covid-19, and Atrocity Prevention in the Philippines
Authors: Tanyag Maria 
Published: August 2022

Abstract
When and why do state responses to crises such as the covid-19 pandemic embody hypermasculinity? How does state hypermasculinity contribute to mortality during a pandemic? This article examines state hypermasculinity as a main atrocity risk factor and as a root cause of preventable deaths arising from failures in pandemic response. It focuses on the case of the Philippines under the leadership of President Rodrigo Duterte to build on feminist scholarship examining gender, crises, and the rise of ‘strongman’ leaders globally. It argues that a state’s predisposition for violence and atrocity crimes renders disease outbreaks more deadly. Significant loss of life and livelihoods during the pandemic are logical outcomes of state structures and responses that combine militarised security, paternalism, and domination of feminised ‘others’. Crucially, the implications of state hypermasculinity extend beyond pandemics as it is clearly emerging as a vector for compounded human insecurities at a time of multiple and overlapping crises.
Liberalising the Chinese Market: State-Owned Enterprise Disciplines in CAI
Authors: Su Xueji 
Published: August 2022

Abstract
The newly-concluded EU-China Comprehensive Agreement on Investment (CAI), characterised by a number of market liberalisation clauses, is the black sheep in the investment agreement family. This article pins down one principal investment liberalisation discipline provided in CAI – the State-owned enterprise (SOE) rule. The article concerns the capability and problems of the new SOE rule in addressing market access issues arising from the competition and incumbency of SOEs. Dedicated SOE disciplines are not an innovation of CAI. Nor does the rule seem strikingly different from state-of-the-art treaty practice. However, delving into the nuances, the article finds that, when it comes to market liberalisation, CAI blurs out the stringent, clear-cut approach the Trans-Pacific Partnership/Comprehensive and Progressive Agreement for Trans-Pacific Partnership model is intended to establish. Further, because both bodies of rules leave plenty of room for interpretation, the effectiveness of the new SOE rule, in general, remains uncertain and susceptible to politicization.
Double nasal presents
Authors: Jasanoff Jay H. 
Published: August 2022

Abstract
Double nasal presents—presents containing both a nasal infix and a nasal suffix—are found in Greek (type λιμπάνω ‘leave’), Celtic (e.g., OIr. ro·finnadar (< *wind-n-) ‘get to know’), and Germanic (Go. du-ginnan (← *-gunnan < *gund-n-) ‘begin’). It is argued here that all such formations have a common origin. The starting point was the nasal-infix present of the root *ghed- ‘grasp’, which originally had the form *gh(n̥)néd-/*ghn̥d-´. With the reinterpretation of the root as *ghend-, the strong stem of the nasal-infix present was remade to *ghn̥d-né/ó-, and in the post-IE period the pattern was extended to other nasal-infix presents (*lin(é)kw- → *linkw-né/ó-, *u̯in(é)d- → *u̯ind-né/ó-, etc.). A corollary of the analysis is that the -a- of the Greek and Armenian presents in *-ane/o- (< *-n̥ne/o-) is epenthetic, and that the absence of a nasal in the root syllable of Arm. lkʿanem, gtanem, etc. is secondary.
Allomorphy in the Hittite common gender accusative plural
Authors: Billing Oscar 
Published: August 2022

Abstract
It has recently become generally accepted that Hittite possessed two non-low back vowel phonemes denoted by means of plene spelling with ⟨u⟩ and ⟨ú⟩, representing /o/ and /u/, respectively. Upon reviewing all available evidence of plene spelling in the Hittite common gender accusative plural ending it is observed that the choice of vowel sign alternates. This forces us to reckon with at least two allomorphs of the ACC.PL.C. ending, -/us/ and -/os/, which in turn demand explanations. The choice of ending appears to be largely contingent on the stem type of the nominal to which it is attached, forming a complementary distribution. For example, ablauting u-stems take -/os/ and i-stems take -/us/. Building on this observation, a diachronic scenario is formulated to account for all observable ending allomorphy. It is argued that the endings of the non-ablauting i-stems and the barytone a-stems were analogically introduced. In the i-stems, the inherited ending -/us/ of the ablauting i-stems was generalised to all i-stems, whereas the source of the ending in the a-stems remains unknown. The sound laws resulting from this analysis indicate that the vocalic outcomes of final *-(V)m# are symmetrical to those of *-(V)ms#, leading to an improved economy in Hittite historical phonology.
Luke
Authors: Blomberg Craig L. 
Published: August 2022

Abstract
I. Howard Marshall broke fresh ground with his Luke: Historian and Theologian in 1970 when the reigning critical methodology was a form of redaction criticism that largely assumed that theology and history were mutually exclusive. Not only did Marshall contest this assumption but he stressed that a historian was as good as his sources, and Luke had good ones. A half-century later, scholarship has significantly progressed, with Marshall’s views having left an important legacy. Multiple critical tools may be combined. Theology and history can work in tandem. Redaction criticism need not be antithetical to the historical reliability of a Gospel.
Reflections on Reflections
Authors: Walton Steve 
Published: August 2022

Abstract
This essay responds to those of Darrell Bock, Craig Blomberg and Mark Strauss looking back on Howard Marshall’s Luke Historian and Theologian after over 50 years. It first highlights the impact of Marshall’s work on the growth in confidence among evangelicals in engaging in NT scholarship, the development of evangelical biblical theology, and (within that) a focus on the message of Luke-Acts. It then sketches four areas for future scholarship which Marshall’s work opens up: further work on the message of Acts; reflection on the place of Judaism and the Jewish people in Acts; fuller engagement with Luke’s theological contribution post-Conzelmann; and a broader and deeper understanding of salvation through a Lukan lens.
On the Terminological Issue of Describing Resurrection as ‘Physical’
Authors: Harriman K. R. 
Published: August 2022

Abstract
From the early centuries of the church, there has been much discussion on how best to describe Jesus’s resurrection and the expected eschatological resurrection (particularly of believers). One popular way of describing resurrection has been as ‘physical’, which in some ways corresponds with the ancient description of the resurrection ‘of the flesh’. Critics of this approach have, in fact, treated these descriptions as synonymous and have argued that ‘physical’ is not an apt adjective for describing Jesus’s or the eschatological resurrection. I argue here, particularly by reference to 1 Cor. 15, that it remains appropriate to refer to resurrection according to the Bible as ‘physical’, not as ‘bodily, but not physical’, and that it is the critics who have overcomplicated the term by making it entail what it does not entail and have thus provided obfuscation where they claimed to provide clarification.
The forgotten world of subaerial desmids (Zygnematophyceae) in the Atlantic Forest, southeast Brazil
Authors: SOPHIA MARIA DA GRAÇA , HUSZAR VERA LÚCIA DE MORAES , BICUDO CARLOS EDUARDO DE MATTOS 
Published: August 2022

Although desmids (Zygnematophyceae) are widely distributed, their diversity in subaerial environments remains little known and explored. Subaerial algae live above the soil in a thin water film, directly exposed to the air. Desmids possess specific strategies to face environmental stress, such as mucilaginous sheaths that enable them to adhere to the substrate and protect the cells against desiccation. Also, zygospore production may be a strategy to survive. We conducted a taxonomic survey of the subaerial desmids in the Atlantic Forest biome (Rio de Janeiro city and other municipalities in the state of Rio de Janeiro). Briefly, we analyzed their strategies to resist sudden environmental changes, especially desiccation, a common condition in this environment. From 2006 through 2008, 100 samples were taken from natural and artificial vertical wet surfaces and tree bark. The material collected was identified based on morphological and metric characteristics of the vegetative and reproductive phases of the life cycle. We identified 57 species, varieties, and taxonomic formae, distributed in 12 genera, 2 orders, and 4 families. The study revealed that most subaerial algae were previously reported for Europe and North and South America. From the total taxa, 12% are reported for the first time for Brazil and 14% for South America. Even though subaerial environments are subject to stressful conditions, only three of the 57 taxa showed adaptive structures such as thick mucilage envelopes, spores, or zygospores.
Siamcapillus rubidus gen. et sp. nov. (Oculatellaceae), a novel filamentous cyanobacterium from Thailand based on molecular and morphological analyses
Authors: TAWONG WITTAYA , PONGCHAROEN PONGSANAT , NISHIMURA TOMOHIRO , SAIJUNTHA WEERACHAI 
Published: August 2022

Cyanobacterial diversity has been extensively studied; however, scant knowledge exists concerning genetic data and higher accuracy for tropical cyanobacterial diversity. In particular, the existence of unnamed monophyletic genera within the Oculatellaceae requires further investigation. Here, two novel strains (NUACC13 and NUACC14) were isolated from a cyanobacterial mat covering border soil of a small freshwater pond in Phitsanulok Province, Thailand. A polyphasic approach combining genetic (16S rDNA and rpoC1 gene phylogenies, evolutionary distance and ITS secondary structures) and morphological information was applied to evaluate the taxonomic status of these novel strains. All phylogenetic analyses of 16S rDNA and rpoC1 gene sequences placed our strains within the Oculatellaceae, strongly supporting a novel monophyletic clade that did not belong to other known Oculatellaceae genera. The 16S rDNA sequence similarity (<96.2%) values among the closest described genera also supported the novelty of our strains. The hypothetical secondary structures (D1–D1′, Box-B, V2 and V3 helices) of the ITS region confirmed the uniqueness of our strains, indicating differences from the related genera. Morphological features of the novel strains differed from the phylogenetically closest taxa by size and color of filament and vegetative cell and the presence of a frayed sheath. Considering all the results, we herein described our strains as the novel genus Siamcapillus gen. nov. in the Oculatellaceae with the type species S. rubidus sp. nov.
Tersilochinae (Hymenoptera: Ichneumonidae) of Japan : two new species, a new combination and 23 new country records
Authors: KHALAIM ANDREY I. 
Published: August 2022

Based on a large amount of material from Japan, two species, Allophroides watanabei sp. nov. and Tersilochus (Tersilochus) serratoides sp. nov., are described as new to science, one new combination, Probles (Euporizon) ecarinata (Khalaim, 2005), comb. nov., is proposed, and following new country records are provided: genus Allophroides Horstmann, Diaparsis (Diaparsis) egregia Khalaim, D. (Nanodiaparsis) ussuriensis Khalaim, Gelanes dentator Khalaim & Lee, G. provectus Balueva & Lee, G. simillimus Horstmann, Phradis gibbus (Holmgren), Ph. vespertinus Khalaim, Probles (Euporizon) carinator Khalaim, Pr. (E.) ecarinata (Khalaim), Pr. (E.) fulgida Khalaim & Balueva, Pr. (E.) hankaensis Khalaim, Pr. (E.) korusa Khalaim & Kim, Pr. (Microdiaparsis) caudiculata Khalaim, Pr. (M.) neoversuta (Horstmann), Pr. (Rugodiaparsis) ruficornis (Szépligeti), Tersilochus (Tersilochus) curvator Horstmann, T. (T.) gangwonus Khalaim & Lee, T. (T.) grandiculus Khalaim, T. (T.) impunctator Khalaim, T. (T.) juxtus Khalaim and T. (T.) liopleuris (Thomson). The number of known Japanese species of Tersilochinae is raised from 25 to 48, or almost double.
Also, Probles (Euporizon) interruptor Khalaim & Lee, Tersilochus (Tersilochus) fidicinus Khalaim & Lee, and T. (T.) gangwonus Khalaim & Lee, are recorded for the first time from Russia. Males of Phradis hikosanus Khalaim and T. (T.) fidicinus Khalaim & Lee are described for the first time. Brief annotations to all occurring in Japan genera, and diagnoses, remarks on taxonomy and colour illustrations to Japanese species, are given.
Effectiveness of power training compared to strength training in older adults: a systematic review and meta-analysis
Authors: el Hadouchi Mohamed , Kiers Henri , de Vries Ralph , Veenhof Cindy , van Dieën Jaap 
Published: August 2022

Abstract
Background
Research suggests that muscle power is a more critical determinant of physical functioning in older adults than muscle strength. The objective of this study was to systematically review the literature on the effect of power training compared to strength training in older adults on tests for muscle power, two groups of activity-based tests under controlled conditions: generic tests and tests with an emphasis on movement speed, and finally, physical activity level in daily life.

Methods
A systematic search for randomized controlled trials comparing effects of power training to strength training in older adults was performed in PubMed, Embase, Ebsco/CINAHL, Ebsco/SPORTDiscus, Wiley/Cochrane Library and Scopus. Risk of bias was assessed using the Cochrane Collaboration Tool, and quality of evidence was evaluated using GRADEpro Guideline Development Tool. Standardized mean differenences (SMD) and 95% confidence intervals (CI) were calculated for outcomes separately using a random effects model.

Results
Fifteen trials and 583 participants were included in the meta-analysis. Results indicated a statistically significant benefit of power training on all reported outcomes (muscle power SMD: 0.99, 95% CI: 0.54 to 1.44, p < 0.001; generic activity-based tests SMD: 0.37, 95% CI 0.06 to 0.68; p = 0.02, activity-based tests emphasizing movement speed SMD: 0.43, 95% CI 0.23 to 0.62, p < 0.001). None of the included studies used physical activity level in daily life as outcome.

Conclusions
Power training offers more potential for improving muscle power and performance on activity tests in older adults compared to strength training. Future research should assess exercise parameters for power training in older adults. In addition, the validity and reliability of the tests used must be evaluated to establish a standardized test protocol. This protocol should also include measurements of physical activity in daily life.
Glutamatergic neurons in paraventricular nucleus of the thalamus regulate the recovery from isoflurane anesthesia
Authors: Bu Xiaoli , Chen Yiqiu , Lv Ping , Fu Xiaoyun , Fu Bao 
Published: August 2022

Abstract
Objectives
Previous studies have demonstrated that the paraventricular nucleus of the thalamus (PVT) is a key wakefulness-controlling nucleus in the thalamus. Therefore, PVT may also be involved in the process of general anesthesia. This study intends to explore the role of PVT in isoflurane anesthesia.

Methods
In the present study, we used the expression of c-Fos to observe the neuronal activity of PVT neurons under isoflurane anesthesia. We further recorded the effect of isoflurane anesthesia on the calcium signal of PVT glutamatergic neurons in real time with the help of calcium fiber photometry. We finally used chemogenetic technology to specifically regulate PVT glutamatergic neurons, and observed its effect on isoflurane anesthesia and cortical electroencephalography (EEG) in mice.

Results
We found that glutamatergic neurons of PVT exhibited high activity during wakefulness and low activity during isoflurane anesthesia. Activation of PVT glutamatergic neuronal caused an acceleration in emergence from isoflurane anesthesia accompanied with a decrease in EEG delta power (1–4 Hz). Whereas suppression of PVT glutamatergic neurons induced a delay recovery of isoflurane anesthesia, without affecting anesthesia induction.

Conclusions
Assuming a pharmacokinetic explanation for results can be excluded, these results demonstrate that the PVT is involved in regulating anesthesia emergence.