bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a feedback-rich culture in academic medicine: the effect of coaching and 360-feedback on physician leadership
Authors: Schwartz Rachel , Weimer-Elder Barbette , Wilkins Elizabeth , Deka Dan , Wong Stephanie , Dang Bryan K. , Brown Ryan , Kline Merisa , Kwan Lawrence 
Published: October 2022

Abstract
Background
This is a time of unprecedented change in healthcare. More physicians are being tasked with stepping into a variety of leadership roles without having received the training needed to be an effective leader. Previous data have demonstrated the effectiveness of both leadership coaching and 360-feedback tools to foster physician well-being and leadership growth. In this proof of concept study, we explore the combined effect of these two tools. The objective of this study was to examine the effect of a brief physician 360 leadership coaching intervention on perception of professional dynamics and acquired leadership skills.

Methods
Participants completed a tailored 360-feedback tool to gather input on their leadership skills, then engaged in five bi-weekly leadership coaching sessions. We conducted a post-intervention semi-structured qualitative interview. Qualitative data were coded using an inductive thematic analysis approach.

Results
Twenty-three primary care physicians at an academic medical center engaged in the 360 leadership coaching study. Participants reported that the intervention yielded valuable benefits in five coaching sessions. Two overarching themes emerged: a Shift in leadership awareness and Navigating their environment. Leadership awareness included increased clarity of purpose and role, and recognition that routine feedback is critical to leadership development. Navigating their environment included gaining relationship-building communication, organizational awareness and navigation strategies.

Conclusions
Combining a tailored 360-feedback tool with a five-session leadership coaching intervention provided physicians with valued support infrastructure for becoming more effective leaders. Physicians described a nuanced understanding of the leadership challenges physicians face, and identified the leadership tools needed to navigate the evolving healthcare delivery landscape. Curricula for physician leadership learning could consider this combination of a customized 360 plus targeted leadership coaching for training physician leaders.
Feasibility and outcome of reproducible clinical interpretation of high-dimensional molecular data: a comparison of two molecular tumor boards
Authors: Rieke Damian T. , de Bortoli Till , Horak Peter , Lamping Mario , Benary Manuela , Jelas Ivan , Rüter Gina , Berger Johannes , Zettwitz Marit , Kagelmann Niklas , Kind Andreas , Fabian Falk , Beule Dieter , Glimm Hanno , Brors Benedikt , Stenzinger Albrecht , Fröhling Stefan , Keilholz Ulrich 
Published: October 2022

Abstract
Background
Structured and harmonized implementation of molecular tumor boards (MTB) for the clinical interpretation of molecular data presents a current challenge for precision oncology. Heterogeneity in the interpretation of molecular data was shown for patients even with a limited number of molecular alterations. Integration of high-dimensional molecular data, including RNA- (RNA-Seq) and whole-exome sequencing (WES), is expected to further complicate clinical application. To analyze challenges for MTB harmonization based on complex molecular datasets, we retrospectively compared clinical interpretation of WES and RNA-Seq data by two independent molecular tumor boards.

Methods
High-dimensional molecular cancer profiling including WES and RNA-Seq was performed for patients with advanced solid tumors, no available standard therapy, ECOG performance status of 0–1, and available fresh-frozen tissue within the DKTK-MASTER Program from 2016 to 2018. Identical molecular profiling data of 40 patients were independently discussed by two molecular tumor boards (MTB) after prior annotation by specialized physicians, following independent, but similar workflows. Identified biomarkers and resulting treatment options were compared between the MTBs and patients were followed up clinically.

Results
A median of 309 molecular aberrations from WES and RNA-Seq (n = 38) and 82 molecular aberrations from WES only (n = 3) were considered for clinical interpretation for 40 patients (one patient sequenced twice). A median of 3 and 2 targeted treatment options were identified per patient, respectively. Most treatment options were identified for receptor tyrosine kinase, PARP, and mTOR inhibitors, as well as immunotherapy. The mean overlap coefficient between both MTB was 66%. Highest agreement rates were observed with the interpretation of single nucleotide variants, clinical evidence levels 1 and 2, and monotherapy whereas the interpretation of gene expression changes, preclinical evidence levels 3 and 4, and combination therapy yielded lower agreement rates. Patients receiving treatment following concordant MTB recommendations had significantly longer overall survival than patients receiving treatment following discrepant recommendations or physician’s choice.

Conclusions
Reproducible clinical interpretation of high-dimensional molecular data is feasible and agreement rates are encouraging, when compared to previous reports. The interpretation of molecular aberrations beyond single nucleotide variants and preclinically validated biomarkers as well as combination therapies were identified as additional difficulties for ongoing harmonization efforts.
Efficacy of metformin therapy in patients with cancer: a meta-analysis of 22 randomised controlled trials
Authors: Wen Jie , Yi Zhenjie , Chen Yuyao , Huang Jing , Mao Xueyi , Zhang Liyang , Zeng Yu , Cheng Quan , Ye Wenrui , Liu Zhixiong , Liu Fangkun , Liu Jingfang 
Published: October 2022

Abstract
Background
To investigate whether metformin monotherapy or adjunctive therapy improves the prognosis in patients with any type of cancer compared to non-metformin users (age ≥18).

Methods
Databases (Medline, Embase, and the Cochrane Central Register of Controlled Trials) and clinical trial registries (ClinicalTrials.gov; the World Health Organization International Clinical Trials Registry Platform) were screened for randomized, controlled trials (RCT) reporting at least progression-free survival (PFS) and/or overall survival (OS). Main outcome measures included hazard ratios (HR), and combined HRs and 95% confidence intervals (CI) were calculated using random-effects models.

Results
Of the 8419 records screened, 22 RCTs comprising 5943 participants were included. Pooled HRs were not statistically significant in both PFS (HR 0.97, 95% CI 0.82–1.15, I2 = 50%) and OS (HR 0.98, 95% CI 0.86–1.13, I2 = 33%) for patients with cancer between the metformin and control groups. Subgroup analyses demonstrated that metformin treatment was associated with a marginally significant improvement in PFS in reproductive system cancers (HR 0.86, 95% CI 0.74–1.00) and a significantly worse PFS in digestive system cancers (HR 1.45, 95% CI 1.03–2.04). The PFS or OS was observed consistently across maintenance dose, diabetes exclusion, median follow-up, risk of bias, and combined antitumoral therapies.

Conclusion
Metformin treatment was not associated with cancer-related mortality in adults compared with placebo or no treatment. However, metformin implied beneficial effects in the PFS of the patients with reproductive system cancers but was related to a worse PFS in digestive system cancers.

Systematic review registration
PROSPERO registration number CRD42022324672.
Head-to-head comparison of the accuracy of saliva and nasal rapid antigen SARS-CoV-2 self-testing: cross-sectional study
Authors: Schuit Ewoud , Venekamp Roderick P. , Veldhuijzen Irene K. , van den Bijllaardt Wouter , Pas Suzan D. , Stohr Joep J. J. M. , Lodder Esther B. , Hellwich Marloes , Molenkamp Richard , Igloi Zsofia , Wijers Constantijn , Vroom Irene H. , Nagel-Imming Carla R. S. , Han Wanda G. H. , Kluytmans Jan A. J. W. , van den Hof Susan , van de Wijgert Janneke H. H. M. , Moons Karel G. M. 
Published: October 2022

Abstract
Background
The diagnostic accuracy of unsupervised self-testing with rapid antigen diagnostic tests (Ag-RDTs) is mostly unknown. We studied the diagnostic accuracy of a self-performed SARS-CoV-2 saliva and nasal Ag-RDT in the general population.

Methods
This large cross-sectional study consecutively included unselected individuals aged $$\ge$$
≥
16 years presenting for SARS-CoV-2 testing at three public health service test sites. Participants underwent molecular test sampling and received two self-tests (the Hangzhou AllTest Biotech saliva self-test and the SD Biosensor nasal self-test by Roche Diagnostics) to perform themselves at home. Diagnostic accuracy of both self-tests was assessed with molecular testing as reference.

Results
Out of 2819 participants, 6.5% had a positive molecular test. Overall sensitivities were 46.7% (39.3–54.2%) for the saliva Ag-RDT and 68.9% (61.6–75.6%) for the nasal Ag-RDT. With a viral load cut-off (≥ 5.2 log10 SARS-CoV-2 E-gene copies/mL) as a proxy of infectiousness, these sensitivities increased to 54.9% (46.4–63.3%) and 83.9% (76.9–89.5%), respectively. For the nasal Ag-RDT, sensitivities were 78.5% (71.1–84.8%) and 22.6% (9.6–41.1%) in those symptomatic and asymptomatic at the time of sampling, which increased to 90.4% (83.8–94.9%) and 38.9% (17.3–64.3%) after applying the viral load cut-off. In those with and without prior SARS-CoV-2 infection, sensitivities were 36.8% (16.3–61.6%) and 72.7% (65.1–79.4%). Specificities were > 99% and > 99%, positive predictive values > 70% and > 90%, and negative predictive values > 95% and > 95%, for the saliva and nasal Ag-RDT, respectively, in most analyses. Most participants considered the self-performing and result interpretation (very) easy for both self-tests.

Conclusions
The Hangzhou AllTest Biotech saliva self Ag-RDT is not reliable for SARS-CoV-2 detection, overall, and in all studied subgroups. The SD Biosensor nasal self Ag-RDT had high sensitivity in individuals with symptoms and in those without prior SARS-CoV-2 infection but low sensitivity in asymptomatic individuals and those with a prior SARS-CoV-2 infection which warrants further investigation.
Sex-specific exposures and sex-combined outcomes in two-sample Mendelian randomization may mislead the causal inference
Authors: Wang Zhenqian , Lu Jiawen 
Published: October 2022

Abstract
With great interest, we have read the recent article “Age at menarche, age at natural menopause, and risk of rheumatoid arthritis — a Mendelian randomization study” by Zhu et al. While we have a great appreciation for the work conducted by the authors, there are some methodological issues that need to be reconsidered. First, the gender description of the sample for age at first birth in this study is wrong according to the original genome-wide association study. Second, the study exploited sex-specific SNPs for age at menarche (AAM) and age at natural menopause (ANM) but sex-combined effects of the SNPs on rheumatoid arthritis (RA) that possibly lead no evidence for the causation of AAM and ANM on RA. We suggested the author add the possible biases due to the issue in the limitations. With problems mentioned above, we recommend solutions to make this article more perfect.
Ivabradine toxicity: a case report
Authors: Singh Kavisha , Alagarraju Muthukumar R. , Wolf Carl E. , Poklis Justin L. , Kulkarni Nitin , Tharpe William , Joshi Parag H. 
Published: October 2022

Abstract
Background
We describe a case of symptomatic bradycardia resulting from ivabradine toxicity by measurement of ivabradine levels, of which there are limited reports in the literature.

Case presentation
A 43-year-old White female presented with several days of near syncope and dizziness accompanied by a drop in her heart rate to 50 beats per minute. She was taking ivabradine for inappropriate sinus tachycardia. After excluding several other causes of bradycardia, we made the diagnosis of ivabradine toxicity by measurement of serum ivabradine levels, an approach that is currently not clinically available.

Conclusions
Measurement of serum ivabradine levels and knowledge of the pharmacokinetic properties of the drug can be utilized to confirm the diagnosis of ivabradine toxicity.
Deciphering chloramphenicol biotransformation mechanisms and microbial interactions via integrated multi-omics and cultivation-dependent approaches
Authors: Zhang Jiayu , Li Xiaoyan , Klümper Uli , Lei Huaxin , Berendonk Thomas U. , Guo Fangliang , Yu Ke , Yang Chao , Li Bing 
Published: October 2022

AbstractBackgroundAs a widely used broad-spectrum antibiotic, chloramphenicol is prone to be released into environments, thus resulting in the disturbance of ecosystem stability as well as the emergence of antibiotic resistance genes. Microbes play a vital role in the decomposition of chloramphenicol in the environment, and the biotransformation processes are especially dependent on synergistic interactions and metabolite exchanges among microbes. Herein, the comprehensive chloramphenicol biotransformation pathway, key metabolic enzymes, and interspecies interactions in an activated sludge-enriched consortium were elucidated using integrated multi-omics and cultivation-based approaches.ResultsThe initial biotransformation steps were the oxidization at the C1-OH and C3-OH groups, the isomerization at C2, and the acetylation at C3-OH of chloramphenicol. Among them, the isomerization is an entirely new biotransformation pathway of chloramphenicol discovered for the first time. Furthermore, we identified a novel glucose-methanol-choline oxidoreductase responsible for the oxidization of the C3-OH group inSphingomonassp. andCaballeroniasp. Moreover, the subsequent biotransformation steps, corresponding catalyzing enzymes, and the microbial players responsible for each step were deciphered. Synergistic interactions betweenSphingomonassp. andCaballeroniasp. orCupriavidussp. significantly promoted chloramphenicol mineralization, and the substrate exchange interaction network occurred actively among key microbes.ConclusionThis study provides desirable strain and enzyme resources for enhanced bioremediation of chloramphenicol-contaminated hotspot sites such as pharmaceutical wastewater and livestock and poultry wastewater. The in-depth understanding of the chloramphenicol biotransformation mechanisms and microbial interactions will not only guide the bioremediation of organic pollutants but also provide valuable knowledge for environmental microbiology and biotechnological exploitation.
Crop management shapes the diversity and activity of DNA and RNA viruses in the rhizosphere
Authors: Muscatt George , Hilton Sally , Raguideau Sebastien , Teakle Graham , Lidbury Ian D. E. A. , Wellington Elizabeth M. H. , Quince Christopher , Millard Andrew , Bending Gary D. , Jameson Eleanor 
Published: October 2022

Abstract
Background
The rhizosphere is a hotspot for microbial activity and contributes to ecosystem services including plant health and biogeochemical cycling. The activity of microbial viruses, and their influence on plant-microbe interactions in the rhizosphere, remains undetermined. Given the impact of viruses on the ecology and evolution of their host communities, determining how soil viruses influence microbiome dynamics is crucial to build a holistic understanding of rhizosphere functions.

Results
Here, we aimed to investigate the influence of crop management on the composition and activity of bulk soil, rhizosphere soil, and root viral communities. We combined viromics, metagenomics, and metatranscriptomics on soil samples collected from a 3-year crop rotation field trial of oilseed rape (Brassica napus L.). By recovering 1059 dsDNA viral populations and 16,541 ssRNA bacteriophage populations, we expanded the number of underexplored Leviviricetes genomes by > 5 times. Through detection of viral activity in metatranscriptomes, we uncovered evidence of “Kill-the-Winner” dynamics, implicating soil bacteriophages in driving bacterial community succession. Moreover, we found the activity of viruses increased with proximity to crop roots, and identified that soil viruses may influence plant-microbe interactions through the reprogramming of bacterial host metabolism. We have provided the first evidence of crop rotation-driven impacts on soil microbial communities extending to viruses. To this aim, we present the novel principal of “viral priming,” which describes how the consecutive growth of the same crop species primes viral activity in the rhizosphere through local adaptation.

Conclusions
Overall, we reveal unprecedented spatial and temporal diversity in viral community composition and activity across root, rhizosphere soil, and bulk soil compartments. Our work demonstrates that the roles of soil viruses need greater consideration to exploit the rhizosphere microbiome for food security, food safety, and environmental sustainability.
Increasingly detailed insights in animal behaviours using continuous on-board processing of accelerometer data
Authors: Yu Hui , Klaassen Chris A.J. , Deng Jian , Leen Trent , Li Guozheng , Klaassen Marcel 
Published: October 2022

AbstractBackground:Studies of animal behaviour, ecology and physiology are continuously benefitting from progressing biologging techniques, including the collection of accelerometer data to infer animal behaviours and energy expenditure. In one of the most recent technological advances in this space, on-board processing of raw accelerometer data into animal behaviours proves highly energy-, weight- and cost-efficient allowing for continuous behavioural data collection in addition to regular positional data in a wide range of animal tracking studies.Methods:We implemented this latest development in collecting continuous behaviour records from 6 Pacific Black DucksAnas superciliosato evaluate some of this novel technique’s potential advantages over tracking studies lacking behavioural data or recording accelerometer data intermittently only. We (i) compared the discrepancy of time-activity budgets between continuous records and behaviours sampled with different intervals, (ii) compared total daily distance flown using hourly GPS fixes with and without additional behavioural data and (iii) explored how behaviour records can provide additional insights for animal home range studies.Results:Using a total of 690 days of behaviour records across six individual ducks distinguishing eight different behaviours, we illustrated the improvement that is obtained in time-activity budget accuracy if continuous rather than interval-sampled accelerometer data is used. Notably, for rare behaviours such as flying and running, error ratios > 1 were common when sampling intervals exceeded 10 min. Using 72 days of hourly GPS fixes in combination with continuous behaviour records over the same period in one individual duck, we showed behaviour-based daily distance estimation is significantly higher (up to 540%) than the distance calculated from hourly sampled GPS fixes. Also, with the same 72 days of data for one individual duck, we showed how this individual used specific sites within its entire home range to satisfy specific needs (e.g. roosting and foraging).Conclusion:We showed that by using trackers allowing for continuous recording of animal behaviour, substantial improvements in the estimation of time-activity budgets and daily traveling distances can be made. With integrating behaviour into home-range estimation we also highlight that this novel tracking technique may not only improve estimations but also open new avenues in animal behaviour research, importantly improving our knowledge of an animal’s state while it is roaming the landscape.
Automatic extraction of upper body landmarks using Rhino and Grasshopper algorithms
Authors: Ryu Eun Joo , Song Hwa Kyung 
Published: October 2022

AbstractThe aim of this study is to develop algorithms for automatic landmark extraction on women with various upper body types and body inclinations using the Grasshopper algorithm editor, which enables the user to interact with the 3D modeling interface. First, 15 landmarks were defined based on the morphological features of 3D body surfaces and clothing applications, from which automatic landmark extraction algorithms were developed. To verify the accuracy of the algorithms on various body shapes, this study determined criteria for key body shape factors (BMI, neck slope, upper body slope, and shoulder slope) that influence each landmark position, classified them into body shape groups and sorted the scan samples for each body type using the 6th SizeKorea database. The statistical differences between the scan-derived measurements and the SizeKorea measurements were compared, with an allowable tolerance of ISO 20685. In the case of landmarks with significant differences, the algorithm was modified. It was found that the algorithms were successfully applied to various upper body shapes, which improved the reliability and accuracy of the algorithm.
Knowledge roadmap of sustainable development in the textile and apparel industry: a scientometric analysis
Authors: Wu Zhaoshan , Zhou Liya , Ding Xuemei , Wu Xiongying , Wang Laili 
Published: October 2022

AbstractPractices in the textile and apparel industry (TAI) have led to numerous environmental and social problems, which have prompted extensive research on the sustainable development of the textile and apparel industry (SDTAI). This paper presents a comprehensive and quantitative analysis of the status quo in the SDTAI domain using scientometrics. From 1987 to 2019, the Web of Science core collection databases (SCI and SSCI) included 863 journal articles related to SDTAI, and our analysis results were as follows: (1) 60 critical research keywords occur in the knowledge base; (2) four research hotspots were identified; (3) five themes constituted the main knowledge area; and (4) based on the knowledge base, research hotspot, and knowledge domain, the knowledge structure consisted of nine subjects and five systems. This paper proposes a knowledge roadmap that can be helpful for practitioners and academicians to better understand the current sustainable development status and trends in the TAI.