bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical, pathological, and oncological outcomes in unclassified renal cell carcinoma compared to clear cell renal cell carcinoma
Authors: Sawczyn Guilherme , Brambilla Caio , Rodrigues Gilberto Jose , Pereira Maykon William Aparecido Pires , Cardili Leonardo , Carvalho Paulo Afonso de , Gallucci Fabio Pescarmona , Sarkis Álvaro Sadek , Nahas William Carlos , Cordeiro Mauricio Dener 
Published: January 2025

ABSTRACT

Purpose:
This study aims to assess the impact of unclassified renal cell carcinoma (uRCC) on clinical, pathological, and oncological outcomes compared with clear cell renal cell carcinoma (ccRCC).

Materials and Methods:
We analyzed the data of 48 uRCC and 688 ccRCC cases, collected from a histopathological database at a single center from July 2011 to August 2019. uRCC cases were confirmed according to the 2016 World Health Organization classification. Baseline characteristics, clinical findings, and oncological outcomes were compared between the groups.

Results:
Patients with uRCC exhibited the same clinical symptoms as ccRCC patients, a higher prevalence of lymphadenopathy (31.2% vs. 15.8%, P < 0.01), and greater sarcomatoid/rhabdoid differentiation on histology (12.5% vs. 5%, P = 0.03) compared to ccRCC patients. Although there was no difference regarding overall metastasis at initial diagnosis, distant lymphadenopathy (16.7% vs. 7.8%, P = 0.04) and liver metastasis (8.9% vs. 2.8%, P = 0.04) were more common in the uRCC group. The two groups had similar high-grade (HG) frequency on histology (62.5% for uRCC vs. 53.7% for ccRCC, P = 0.23). The estimated recurrence-free survival at 48 months was 94.3% for uRCC, 92.5% for low-grade (LG) ccRCC (P = 0.91), and 66.5% for HG ccRCC (P < 0.01). The estimated overall survival at 48 months was 66.1% for uRCC, 87.4% for LG ccRCC (P = 0.75), and 63.4% for HG ccRCC (P < 0.01).

Conclusion:
Our study demonstrates that uRCC has significantly higher rates of lymphadenopathy, sarcomatoid differentiation, and liver metastasis compared to ccRCC. Despite these differences, uRCC presents with similar clinical symptoms and histological grade as ccRCC. Furthermore, uRCC exhibits a recurrence rate comparable to LG ccRCC and an overall survival rate similar to HG ccRCC.
Single-port robot-assisted pyeloplasty through supine anterior retroperitoneal access
Authors: Sobhani Sina , Hemal Sij 
Published: January 2025

ABSTRACT
This video explores the technique of robot-assisted pyeloplasty using the Da-Vinci Single-Port robot through the supine anterior retroperitoneal access in a 28-year-old male with a right-sided ureteropelvic junction obstruction. The patient was placed in a supine position, with a 10°–20° elevation of the ipsilateral flank. Retroperitoneal access was obtained at the McBurney’s point for the placement of the port. The standardized steps of the Anderson–Hynes pyeloplasty technique were executed. Operative time was 120 min with 10 mL of blood loss. The patient was discharged on the same day without complications. At 4-months follow-up, on the renal scan, the right kidney showed stable function with improved drainage.
Association of retinal sensitivity with gestational hypertension and obesity
Authors: Nandi Debasmita , Majumdar Swati , Banerjee Prosenjit 
Published: January 2025

Background:
Pregnancy-induced hypertensive disorders occur in about 5% to 8% of all pregnant women in the world and are associated with various pathological changes in the retina due to vasospasm which might have long-term effects on other vital organs too. These may cause changes in retinal sensitivity which can be measured by static automated perimetry. Obesity in pregnancy also carries the risk of development of hypertension (HTN) and, therefore, various complications in both the mother and fetus.

Aim:
The aim is to study and compare retinal sensitivity by static automated perimetry in pregnant females with HTN and/or obesity.

Setting and Design:
This was a prospective cross-sectional study in a tertiary care center.

Materials and Methods:
Fifty pregnant females with HTN and/or obesity as cases and 54 as controls underwent systemic and ocular examination including retinal sensitivity measurement at 20 and 32 weeks of gestation.

Statistical Analysis:
Statistical software SPSS version 22 was used.

Results:
A significant decrease in mean retinal sensitivity (−7.71 ± 3.67 decibels, P < 0.001) and foveal sensitivity was observed in cases at 32 weeks of gestation compared to controls. With a 5 mmHg increase in systolic blood pressure, retinal sensitivity decreased by 0.795 decibels.

Conclusion:
Gestational HTN was associated with decreased retinal sensitivity compared to normal pregnant females without any observable retinal changes. Noninvasive investigation such as automated perimetry thus can provide us with valuable information regarding vascular changes in the retina which can involve other vital organs including placental circulation at the same time.
Virtual reality-based eye examination at a community-free clinic: A pilot study
Authors: Valadez Jullian , Zhang Howard , Groth Sylvia L. 
Published: January 2025

Aims:
This study aims to implement a comprehensive virtual reality (VR) eye examination at a free clinic and to compare its accuracy, time efficiency, and patient satisfaction to the manual examination.

Settings and Design:
Prospective pilot study.

Materials and Methods:
Adult patients attending a monthly clinic underwent standard examination followed by VR visual acuity (VA), visual field (VF), extraocular movements (EOM), pupillometry, and Ishihara testing. The tests were timed, and patient preferences were surveyed.

Statistical Analysis Used:
Mann–Whitney U-test for examination duration, Wilcoxon signed-rank test for patient preferences, and intraclass correlation analysis for VA results.

Results:
Fifty eyes across 25 participants were included. The participants were mostly female (84%) with a median age of 52 years (interquartile range [IQR] 12), and the majority spoke Spanish as their primary language (68%). The VR examination (median 6.61 min, IQR 3.35), excluding 3 min of tutorials, was significantly faster than the manual examination (median 17 min, IQR 9.5, P < 0.001). The VR far VA results positively correlated with the manual examination (intraclass correlation coefficient 0.628, P < 0.001). The VR VF, EOM, pupil, and Ishihara color test results matched the manual examination (no abnormal findings were missed). Eighty-two percent of survey participants preferred the VR examination, which received high ratings in physical comfort (mean 4.45/5, standard deviation [SD] 0.89) and interface (mean 4.55/5, SD 0.84) as compared to the manual examination (mean 4.14/5, SD 0.92, P = 0.074).

Conclusions:
Our study identified a VR-based examination that increased the scope of ocular testing, efficiency, and patient satisfaction in a free clinic.
Spectral domain optical coherence tomography findings predicting visual outcome in patients with rhegmatogenous retinal detachment undergoing retinal detachment surgery
Authors: Shah Pankti , Desai Tejas H 
Published: January 2025

Purpose:
The purpose of the study was to investigate spectral domain optical coherence tomography (SD-OCT) findings as predictors of visual outcomes in patients undergoing retinal detachment (RD) surgery for rhegmatogenous RD (RRD).

Materials and Methods:
A prospective study was conducted on 50 eyes diagnosed with RRD, aged between 10 and 80 years, who underwent RD surgery at a tertiary eye care hospital between September 2018 and February 2020. Comprehensive ophthalmic evaluations were performed, and SD-OCT images were analyzed in addition to clinical assessments.

Results:
Significant improvements were observed in best-corrected visual acuity (BCVA) and central foveal thickness (CFT) at the end of the 12th week, with mean values of 0.79 ± 0.34 (range: 0.30–1.78) and 261.72 ± 58.13 (range: 201–433), respectively. Postoperatively, epiretinal membrane was detected in 14 (28%) patients, whereas external limiting membrane (ELM) disruption was noted in 8 (16.0%) patients. The percentage of photoreceptor inner segment/outer segment (IS/OS) disruption in RRD patients was 11 (22.0%), and 8 (16.0%) patients had subretinal fluid (SRF). Intraretinal fluid was absent in all patients postoperatively.

Conclusion:
High-resolution imaging by SD-OCT facilitates the interpretation of retinal anatomy and enables the detection of clinically nonevident structures. ELM disruption, IS/OS disruption, and the presence of SRF were associated with poor visual outcomes. While no statistically significant difference was found in the presence of SRF between macula-on and macula-off RRD patients, ELM and IS/OS disruption was observed only in macula-off RRD cases. Overall, macula-on patients showed improvements in BCVA and CFT at the end of the 12 weeks compared to macula-off RRD patients following RD surgery.
Potential of hospital corneal retrieval program in tertiary care center
Authors: Weladi Ujwala , Chaurasia Snehal Bonde 
Published: January 2025

Context:
In developing nations, corneal diseases are the second leading cause of blindness. Despite the effectiveness of corneal transplantation, India struggles with a substantial corneal blind population and inadequate access to quality donor corneal tissue. Addressing this gap between demand and supply is essential to combat the prevalence of corneal blindness.

Aims:
The aim of this study is to study the potential of hospital-based cornea retrieval program (HRCP) at tertiary care center.

Subjects and Methods:
A retrospective, record-based study was conducted, encompassing all hospital deaths at a tertiary center over a 2-year period from January 2016 to December 2017. Data regarding demographic profiles and causes of death due to systemic diseases were collected from the medical records. The study analyzed the number of patients from whom corneal retrieval could have been possible, after excluding those patients in whom corneal retrieval was contraindicated as per the guidelines of the National Program for Control of Blindness.

Results:
In 2016, a total of 6001 deaths occurred at the tertiary care center, with 2345 (39.01%) contraindicated for donor corneal retrieval. Corneas were retrieved from 42 patients, resulting in 84 corneal buttons and a retrieval rate of 0.70% of total deaths, while the potential corneal retrieval rate was 60.92%. In 2017, out of 5532 deaths, 2066 (37.38%) were contraindicated for donor corneal retrieval. Corneas were retrieved from 82 patients, yielding 164 corneal buttons and reflecting a retrieval rate of 1.48% of total deaths, with the potential corneal retrieval rate at 62.65%.

Conclusions:
The study highlights the potential and effectiveness of the hospital cornea retrieval program (HCRP) in a tertiary care center, with retrieval rates improving from 0.70% in 2016 to 1.48% in 2017. The gap between actual and potential retrieval rates highlights the need for better strategies. Addressing cultural barriers, superstitions, and the lack of local eye banks are crucial. Enhancing public awareness through trained counselors in hospitals and regular reorientation of medical personnel can significantly improve eye donation programs, benefiting patients awaiting corneal transplants, and reducing corneal blindness.
Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume in patients with diabetic retinopathy
Authors: Ghosh Trisha , Thakur Sanjay Kumar Daulat , Ghosh Premangshu , Sengupta Trina 
Published: January 2025

Objective:
The objective of this study was to assess the role of inflammation in the pathogenesis of diabetic retinopathy (DR) using the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and to compare these parameter levels between DR and non-DR (NDR) subjects.

Materials and Methods:
A cross-sectional study was conducted among 60 patients with a definite diagnosis of type 2 diabetes mellitus attending the ophthalmology outpatient department of a tertiary care hospital. We obtained blood samples from all individuals who participated in the study to investigate these parameters.

Results:
Sixty subjects were included in this study: 30 in the DR group and 30 in the NDR group. The mean NLR, PLR, and MPV levels were higher in DR subjects than in NDR subjects (NLR: 2.49 ± 0.82 in DR group vs. 1.94 ± 0.75 in NDR group, P = 0.003; PLR: 114.82 ± 5.08 in DR group vs. 104.5 ± 6.73 in NDR group, P = 0.01; and MPV: 11.08 ± 1.28 in DR group vs. 9.92 ± 1.63 in NDR group, P = 0.003).

Conclusion:
The higher NLR, PLR, and MPV levels found in patients with DR may indicate that subclinical systemic inflammation may be associated with DR. Understanding the potential association between NLR, PLR, MPV, and DR holds promise in providing valuable clinical information for the early detection and effective management of DR. Moreover, unraveling the underlying mechanisms linking these ratios with the pathophysiology of DR could contribute to the development of targeted screening and therapeutic interventions.
Human Activity Recognition with Smartphones Using Machine Learning
Authors: Alghamdi Wejdan , Alshahrani Ameerah , Otaif Nehal , Alqurashi Najlaa 
Published: January 2025

Human activity recognition is widely used now in many applications, such as smart homes, health care, and business as well as in a wide range of pattern recognition and human-computer interaction research. In this paper, we use the same sensors embedded in smartphones (Accelerometer and Gyroscope) to track and recognize human activities. We employ a machine-learning algorithm, which is the Support Vector Machine (SVM) to improve the performance of human activity recognition. The experimental results on the HAR Dataset from the UCI repository indicate that our approach is practical and achieves 96% accuracy.
Penyuluhan Pengaruh Pemberian Makanan Tambahan Terhadap Peningkatan Berat Badan Gizi Kurang Pada Balita di Posyandu Wilayah Kerinjing
Authors: Sastri Nen 
Published: January 2025

Gizi kurang atau gizi buruk merupakan kondisi kekurangan gizi akut yang dinilai berdasarkan berat badan menurut panjang badan atau tinggi badan (BB/PB atau BB/TB). Gizi kurang adalah anak usia 6-59 bulan dengan BB/ PB atau BB/TB <-2 SD atau nilai Lingkar Lengan Atas (LiLA) antara ≥11,5 cm namun <12,5 cm hingga <-3 SD atau nilai LiLA<11,5 cm. Balita berisiko gizi kurang atau gizi buruk yang perlu dirujuk adalah: Balita (6-59 bulan) dengan LiLA kuning (11,5 - < 12,5 cm) dan merah (<11,5 cm), Balita yang mengalami hambatan pertumbuhan. Balita dengan pitting edema bilateral, Balita yang tampak kurus, Bayi < 6 bulan yang mengalami kesulitan menyusu baik disebabkan karena faktor bayi maupun faktor ibu [1]. Berdasarkan data posyandu di desa Kerinjing selama 3 tahun terakhir terlihat peningkatan berat badan balita gizi kurang dengan melakukan penyuluhan kesehatan tentang pemberian makanan tambahan. Metode yang digunakan pendidikan masyarakat (penyuluhan) dan konsultasi. Sebelum dilakukan penyuluhan ibu diberikan pertanyaan dengan hasil dari 18 responden ibu yang mempunyai pengetahuan baik yaitu 2 ibu (11,11%), pengetahuan cukup sebanyak 9 ibu (50%), pengetahuan kurang yaitu 7 ibu (38,89%). Setelah dilakukan penyuluhan ibu kembali diberikan pertanyaan dengan hasil dari 18 responden ibu yang mempunyai pengetahuan baik yaitu 13 ibu (72,22%), pengetahuan cukup sebanyak 5 ibu (27,78%). Simpulan: setelah dilakukan penyuluhan pengetahuan ibu meningkat lebih baik dibandingkan sebelum dilakukan penyuluhan.
TRANSFORMASI PENDIDIKAN MATEMATIKA DI ERA TEKNOLOGI: KAJIAN FILSAFAT TENTANG IMPLIKASI IPTEK
Authors: Susanti Ade , Jainuri Muhammad , Asyhar Rayandra 
Published: January 2025

The transformation of mathematics education in the technological era has presented significant new challenges and opportunities in the learning process. The main problems faced include unequal access to technology, lack of teacher training, and resistance to changes in traditional teaching methods. To understand the impact and implications of this transformation, this study uses a literature review method that includes a variety of sources, including journal articles, books, and recent research reports. The subjects analyzed included various technological tools used in mathematics education, such as interactive software and online learning platforms, as well as pedagogical approaches that support technology integration. The analysis results show that the application of technology in mathematics education can improve students' understanding of concepts, interactivity, and engagement and provide better accessibility to learning resources. However, challenges such as lack of adequate training and access gaps remain obstacles that must be addressed. The conclusion of this study emphasizes the importance of continuous support for teachers and students to maximize the potential of technology in education. With the right approach, this transformation can create a more inclusive and effective learning environment, preparing students to face the challenges of an increasingly digital world
SISTEM INFORMASI MANAJEMEN CATERING MENGGUNAKAN CUSTOMER RELATIONSHIP MANAGEMENT (CRM) BERBASIS WEB
Authors: Fitria Nazla , Harahap Aninda Muliani , Sibarani Fathiya Hasyifah 
Published: January 2025

Mazaya Catering merupakan salah satu Usaha UMKM yang bergelut dibidang jasa yang melayani pemesanan catering dalam jumlah banyak untuk acara besar seperti pernikahan, syukuran, akikah, dan lainnya yang mencakup jumlah pesanan diatas 100 pax. Penelitian ini menggunakan metode Waterfall dalam membentuk dan pengembangan sistem informasi manajemen catering berbasis web, serta metode Kualitatif pada proses penelitian. Prinsip pada Customer Relationship Management (CRM) digunakan sebagai prinsip promosi yang digunakan pada pengembangan sistem ini. Hasil penelitian ini menunjukkan Sistem Informasi Manajemen Catering berbasis website yang telah dibangun menyediakan beberapa fitur yang dapat membantu proses berjalannya bisnis catering di Mazaya Catering. Yaitu diskon/potongan harga, FAQ (Frequently Asked Questions), Testimoni, WhatsApp dan Instagram Link, dan Pembayaran via Rekening. Kata Kunci— Catering, Customer Relationship Management, UMKM, Waterfall. Abstract— Mazaya Catering is one of the MSME businesses that is engaged in services that serve catering orders in large quantities for large events such as weddings, thanksgiving, akikah, and others which include orders above 100 pax. This research uses the Waterfall method in shaping and developing web-based catering management information systems, as well as Qualitative methods in the research process. The principles of Customer Relationship Management (CRM) are used as promotional principles used in the development of this system. The results of this study show that the web-based Catering Management Information System that has been built provides several features that can help the process of running a catering business at Mazaya Catering. Namely discounts / discounts, FAQ (Frequently Asked Questions), Testimonials, WhatsApp and Instagram Links, and Payment via Account. Keywords— Catering, Customer Relationship Management, UMKM, Waterfall.
Factors Influencing the Quality of Managing Severe Malaria among Children under Five Years at Selected County Hospitals in Kisumu, Kenya
Authors: Maoga Rose , Chebor Alex , Bonface Nyumbile 
Published: January 2025

Context: Severe Malaria in children under the age of five is a major public health issue in Kisumu County, a malaria-endemic area in Kenya. Moreover, most severe Malaria cases in Kisumu West Subcounty are managed at Kombewa and Chulaimbo County hospitals. However, the influence of patient-related, caregiver-related, healthcare provider (HCP), and institutional-related factors on the management of severe Malaria in the area is not known.
Aim: The present study aimed to determine the factors influencing the quality of managing severe Malaria among children under five years at selected County hospitals in Kisumu, Kenya, namely Chulaimbo County Hospital and Kombewa County Hospital.
Methods: A mixed-methods prospective cross-sectional study was conducted between April and July 2023. Qualitative data was collected from eight key informants (hospital administrators and ward in charge), while quantitative data was collected from 344 caregivers of children under five years of age who were managed for severe Malaria and 78 healthcare providers (nurses, clinical officers, and doctors) using survey questionnaires. An observational checklist was also used to collect quantitative data. Thematic analysis was used to analyze qualitative data, while descriptive statistics and logistic regression were used to analyze quantitative data. p<0.05 was considered significant.
Conclusion: These findings suggest that the optimal management of severe Malaria in children under the age of five in the study area is influenced by the gender of the patient, characteristics of the caregivers, on-job training of healthcare providers, and the availability of antimalarial medication. Moreover, these findings suggest that while healthcare providers are knowledgeable and committed to quality malaria management, systemic challenges such as resource limitations, caregiver education gaps, and treatment non-adherence impact their ability to deliver optimal care. Addressing these issues through resource allocation, continuous provider training, and community health education could strengthen severe malaria management in Kisumu County.
The Legal Nature of the Enforceability of Legal Action (Comparative Study)
Authors: Marouf Hussein Abdel Qader , Adnan Ali Karim Fayez 
Published: January 2025

Objectives: The objective is to analyze how the legal nature of an act determines its position in relation to other legal acts and situations. It aims to clarify how the legal nature of a legal act or fact influences the enforcement and the effects that arise from this nature.

Methods: The methods involve examining various cases related to the act, particularly focusing on its enforcement and the resulting effects of the right that arises from the act. These cases help in identifying and understanding the implications of the legal nature.

Results: The results highlight that the legal nature determines both the internal and external effects of an act, establishing its position within the legal system. The effects of the right arising from the act are shaped by its nature, and the enforcement process is guided by addressing these effects.

Conclusion: The conclusion emphasizes that the legal nature of an act is crucial in determining its effects, both in relation to enforcement and the rights that arise from it. Furthermore, the enforcement process is independent and continues as long as the legal situation persists, not ending until the act or its associated right concludes.