bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of change of multisite pain over 1 year of follow‐up and related risk factors
Authors: Ntani Georgia , Coggon David , Felli Vanda E. , Harari Florencia , Barrero Lope H. , Felknor Sarah A. , Rojas Marianela , Serra Consol , Bonzini Matteo , Merisalu Eda , Habib Rima R. , Sadeghian Farideh , Wickremasinghe A. Rajitha , Matsudaira Ko , Nyantumbu‐Mkhize Busisiwe , Kelsall Helen L. , Harcombe Helen , Walker‐Bone Karen 
Published: May 2022

AbstractBackgroundMultisite musculoskeletal pain is common and disabling. This study aimed to prospectively investigate the distribution of musculoskeletal pain anatomically, and explore risk factors for increases/reductions in the number of painful sites.MethodsUsing data from participants working in 45 occupational groups in 18 countries, we explored changes in reporting pain at 10 anatomical sites on two occasions 14 months apart. We used descriptive statistics to explore consistency over time in the number of painful sites, and their anatomical distribution. Baseline risk factors for increases/reductions by ≥3 painful sites were explored by random intercept logistic regression that adjusted for baseline number of painful sites.ResultsAmong 8927 workers, only 20% reported no pain at either time point, and 16% reported ≥3 painful sites both times. After 14 months, the anatomical distribution of pain often changed but there was only an average increase of 0.17 painful sites. Some 14% workers reported a change in painful sites by ≥3. Risk factors for an increase of ≥3 painful sites included female sex, lower educational attainment, having a physically demanding job and adverse beliefs about the work‐relatedness of musculoskeletal pain. Also predictives were as follows: older age, somatizing tendency and poorer mental health (each of which was also associated with lower odds of reductions of ≥3 painful sites).ConclusionsLongitudinally, the number of reported painful sites was relatively stable but the anatomical distribution varied considerably. These findings suggest an important role for central pain sensitization mechanisms, rather than localized risk factors, among working adults.SignificanceOur findings indicate that within individuals, the number of painful sites is fairly constant over time, but the anatomical distribution varies, supporting the theory that among people at work, musculoskeletal pain is driven more by factors that predispose to experiencing or reporting pain rather than by localized stressors specific to only one or two anatomical sites.
Migration time correction for dual pressure capillary electrophoresis in semi‐targeted metabolomics study
Authors: Huang Zi‐Ao , Tan Jiahua , Li Yueyang , Miao Siyu , Scotland Kymora B. , Chew Ben H. , Lange Dirk , Chen David D. Y. 
Published: May 2022

AbstractMigration time fluctuation strongly affects peak alignment and identification of unknown compounds, making migration time correction an essential step in capillary electrophoresis (CE)‐based metabolomics. To obtain more reliable information, metabolites with different apparent mobilities are analyzed by tandem mass spectrometry. Applying a small pressure is a common practice for reducing the analysis time of anions in a positive mode CE, known as the pressure‐assisted CE. However, applying pressure may reduce the separation efficiency and can be undesirable for cation analysis. A simple way to address this issue is to increase the pressure after a certain time, during the separation. We term this practice as dual pressure CE. However, changing the pressure during the CE separation complicates migration time correction. Previous migration time correction methods were established based on a consistent electroosmotic flow and a constant pressure‐driven bulk‐flow velocity. We proposed a new correction method to support the peak alignment when dual pressure CE is used. A Python‐based script was developed to implement dual pressure CE migration time correction for semi‐targeted metabolomics study performed by a multiple reaction monitoring–based method. This script can help select suitable endogenous metabolites as correction markers, perform migration time correction, and conduct peak alignment. A case study showed that migration time precision of 156 metabolites in 32 samples can be improved from 4.8 to 11.4%RSD (relative standard deviation) to less than 1.8%RSD.
High‐level expression of xyloglucanase B from Rhizomucor miehei and its application in the preparation of partially hydrolyzed apple pomace xyloglucan
Authors: Wang Nan‐nan , Li Yan‐xiao , Zhu Chun‐hua , Yan Qiao‐juan , Shi Ran , Jiang Zheng‐qiang 
Published: May 2022

AbstractA xyloglucanase gene (RmXEG12B) was cloned from Rhizomucor miehei CAU432 and successfully expressed in Pichia pastoris. The highest xyloglucanase activity of 26,200 U/mL was achieved after 168 h high‐cell‐density fermentation. The optimal pH and temperature of RmXEG12B were 5.0 and 55°C, respectively. RmXEG12B showed good stability within pH of 3.0–10.0 and was stable up to 50°C. It exhibited the highest specific activity (5989.3 U/mg) towards tamarind xyloglucan. RmXEG12B hydrolyzed apple pomace xyloglucan to produce the partially hydrolyzed apple pomace xyloglucan, which demonstrated a weight average molecular weight of 1.6 × 104 Da and contained three major oligosaccharides with a degree of polymerization of 7–10. This is a strategy for the comprehensive utilization of apple pomace to produce the partially hydrolyzed apple pomace xyloglucan.
Numerical study of Williamson hybrid nanofluid flow with thermal characteristics past over an extending surface
Authors: Alhowaity Awatif , Hamam Haneen , Bilal Muhammad , Ali Aatif 
Published: May 2022

AbstractThe energy and mass dissemination rate have been studied through Williamson hybrid nanofluid (NF) flow comprised of silver (Ag) and magnesium oxide (MgO) nanoparticles (NPs) past over an extending porous surface. The hybrid nanofluid has synthesized by dispersion of Ag and MgO nanoparticles in the base fluid (engine oil). The effects of the constant magnetic field, thermal dissipation, and heat source are also studied in the present analysis. The above scenario has been designed in the form of a nonlinear system of partial differential equations, which are processed through a similarity framework to the system of dimensionless ordinary differential equations. The results are obtained by the numerical computational approach parametric continuation method. It has been perceived that the velocity contour decreases with rising upshots of porosity parameter Kp and magnetic force M, while enhances with the variation of volume friction coefficient. The increment of Biot number Bi, heat source Q, and Eckert number Ec enhances the energy profile, respectively. Furthermore, the mass conversion rate decreases with the variation of thermophoretic parameters and Schmidt number.
Risk factors associated with accidental fetal skin lacerations during cesarean delivery
Authors: Har‐Shai Lior , Kreichman Rita , Kedar Reuven , Osovsky Micky , Chen Rony , Lavi Idit , Metanes Issa , Segal Miriam , Ofek Sar‐El , Mattar Samar , Hassan Samer , Kramer Aviv , Bryzgalin Leonid , Ad‐El Dean , Sagi‐Dain Lena , Lavie Ofer , Har‐Shai Yaron 
Published: May 2022

AbstractObjectiveTo identify risk factors associated with accidental fetal skin lacerations (AFL) during cesarean section (CS).MethodsThis retrospective cohort study was obtained from the registry of two large medical centers between 2014 and 2019. The study group comprised all newborns identified with AFL. The rates of various potential risk factors were compared between the study group and a group of CS at which no AFL had occurred (the control group).ResultsOf the 14 666 CS deliveries, 48 cases of AFL (0.33%) were documented, 52% of these following urgent CS. Compared with the control group (n = 14 618), the only risk factors associated with AFL were premature rupture of membranes (PROM) (odds ratio [OR] 5.38, 95% convidence interval [CI] 2.97–9.74) and meconium‐stained amniotic fluid (OR 6.50, 95% CI 2.55–16.54). In subgroup analysis by CS urgency, no significance for these factors was noted in elective CS group; but higher rates of both PROM and meconium‐stained amniotic fluid were noted in the AFL during urgent CS (OR 14.23, 95% CI 6.30–32.16 and OR 15.36, (95% CI 5.65–41.75, respectively).ConclusionsDuring urgent CS, the surgeon should bear in mind that the presence of PROM or meconium‐stained amniotic fluid should prompt extra care and application of preventive measures to decrease the rates of AFL.
Anemia in pregnant women according to two different assessment criteria (WHO versus CDC)
Authors: dos Santos Camila Carvalho , da Silva Suzana Lins , Costa Caminha Maria de Fátima , Maia Sabina Bastos , Figueiroa José Natal , Batista Filho Malaquias 
Published: May 2022

AbstractObjectiveTo determine the prevalence of anemia among pregnant women and the associated factors and perinatal outcomes according to two different diagnostic criteria: the WHO criterion and the US Center for Disease Control and Prevention (CDC) criterion.MethodsCohort study, operationalized through a database. The sample comprised 781 pregnant women who had laboratory data regarding hemoglobin levels during the second trimester of pregnancy. Anemia was diagnosed when hemoglobin was less than 11 g/dl according to WHO and less than 10.5 g/dl according to CDC. Factors possibly associated with anemia were identified by adjusting Poisson univariate and multivariate regression models. To analyze the association between perinatal outcomes and anemia, the χ2 test and Fisher exact test were performed.ResultsThe prevalence of anemia was 22.9% according to WHO and 10.9% according to CDC. A significantly higher risk of low birth weight was found in children of women with anemia, regardless of the diagnostic criteria used, while a greater risk of having a small‐for‐gestational‐age newborn was seen only when the CDC criterion were applied.ConclusionAnemia during pregnancy remains an important public health issue, but its magnitude may be overestimated by overly sensitive assessment criteria.
Analysis of prognostic factors in Grade 3 endometrioid type endometrial carcinoma
Authors: Sahin Eda Adeviye , Toprak Serhat , Sayal Hasan Berkan , Ekinci Tekin , Yılmaz Ercan , Bakay Kadir , Melekoğlu Rauf , Sezgin Burak , Tohma Yusuf Aytaç , Şahin Hanifi 
Published: May 2022

AbstractObjectiveTo investigate the prognostic factors of patients with Grade 3 endometrioid endometrial cancer (G3EEC).MethodsThis four‐center, retrospective study included a total of 129 women with G3EEC. Demographic, clinicopathologic, and survival data were collected. Kaplan–Meier method was used for survival analysis. Predictors of outcome were analyzed using Cox proportional hazards models.ResultsMedian age at the time of diagnosis was 63 (range 39–87) years and median follow up was 37 (range 6–126) months. For the entire cohort, the 5‐year disease‐free survival (DFS) and overall survival (OS) were 54.3% and 63.6%, respectively. The 5‐year DFS rates for lymphovascular space invasion (LVSI) ‐positive and ‐negative patients were 41.6% and 88.3%, respectively (P < 0.001). The 5‐year OS rates for LVSI‐positive and ‐negative patients were 54.7% and 88.3%, respectively (P = 0.001). Positive LVSI status was identified as the independent prognostic factor for decreased DFS and OS (hazard ratio [HR] 5.5, 95% confidence interval [CI] 1.65–18.86; P = 0.006 versus HR 4.4, 95% CI 1.33–14.58; P = 0.013, respectively).ConclusionLVSI seems to be an independent prognostic factor for decreased DFS and OS in G3EEC patients.
Splenic artery aneurysm in pregnancy: A systematic review
Authors: Aung Yuri Yin‐Moe , Berry Chinar , Jayaram Prem Ruben , Woon Ee Von 
Published: May 2022

AbstractObjectiveSplenic artery aneurysms (SAA) are associated with significant maternal and fetal mortality when ruptured in pregnancy. However, there is no consensus on the optimal obstetric management of both ruptured and asymptomatic SAA. We aimed to evaluate risk factors, presentation, investigation, and management of SAA in pregnancy and puerperium.MethodsMEDLINE, EMBASE, and Scopus were screened from January 2000 to October 2020 using keywords related to pregnancy and SAA. Articles on ruptured and unruptured SAA in pregnancy until 6 weeks postpartum were considered. Data were extracted by two independent reviewers. Quantitative analysis and narrative synthesis were used.ResultsSeventy‐five ruptured and nine unruptured SAA cases were included. Mean age was 31.1 ± 5.2 years, of which 47 (64.4%) were multiparous and 46 (54.8%) presented in their third trimester, largely with epigastric and left‐sided abdominal pain. The double‐rupture phenomenon of delayed blood loss and symptoms was noted in 11 (14.7%); 60 (70.7%) underwent preoperative imaging. Mean SAA size was 23.0 ± 13.6 mm. Ruptured SAA were primarily managed by laparotomy (61, 81.3%) typically with splenectomy, and unruptured SAA by embolization or laparotomy. There was no mortality in unruptured SAA, but significant mortality on rupture (19, 25.7% maternal; 36, 50.0% fetal).ConclusionGiven their predisposition and high mortality in pregnancy, it is crucial that SAAs are promptly diagnosed and managed, requiring increased obstetrician awareness.
Impact of enhanced recovery implementation in women undergoing abdominal sacrocolpopexy
Authors: Trad Ayssa Teles Abrao , Tamhane Prajakta , Weaver Amy L. , Baker Mary V. , Visscher Sue L. , Borah Bijan J. , Kalogera Eleftheria , Gebhart John B. , Trabuco Emanuel C. 
Published: May 2022

AbstractObjectiveTo assess the effect of Enhanced Recovery After Surgery (ERAS) with and without liposomal bupivacaine (LB) on opioid use, hospital length of stay (LOS), costs, and morbidity of women undergoing sacrocolpopexy.MethodsRetrospective cohort of women who underwent abdominal sacrocolpopexy between April 1, 2009 and November 30, 2017. Costs for relevant healthcare services were determined by assigning 2017 charges multiplied by 2017 Medicare Cost Report's cost to charge ratios. Outcomes were compared among periods with multivariable regression models adjusted for age, American Society of Anesthesiologists score, and concurrent hysterectomy and posterior repair.ResultsPatients were subdivided into pre‐ERAS (G1, n = 128), post‐ERAS (G2, n = 83), and post‐ERAS plus LB (G3, n = 91). The proportion of patients needing opioids during postoperative days 0–2 was significantly less for G3 (75.8%) compared with G1 (97.7%) and G2 (92.8%); P < 0.001). The median morphine equivalent units (MEU) with interquartile ranges, mean LOS, and adjusted mean standardized costs were significantly lower in G3 compared with the other two groups (35 [20–75] vs. 67 [31–109], and 60 [30–122] MEUs; 1.8 vs. 2.3 vs. 2.9 days; and $2391, $2975, and $3844, for G3, G2, and G1, respectively; P < 0.001).ConclusionImplementation of an ERAS pathway led to significant decreases in opioid use, LOS, and costs. Supplementation with LB further improved these measures.
Diagnostic efficacy of serum ST2 in patients with ASC
Authors: Ren Yaping , Hou Min , Ren Yunxia , Zhang Lei 
Published: May 2022

AbstractBackgroundSoluble suppression of tumorigenicity 2 (ST2) is closely related to the development of cardiovascular disease, but the level of acute coronary syndrome (ACS) and the relationship between ST2 and ACS are unclear.Patients and MethodsPatients with the acute coronary syndrome were divided into the unstable angina pectoris (USAP) group (n = 65) and non‐ST‐segment elevation myocardial infarction (NSTEMI) group (n = 58), and the healthy population, without chest pain and with normal coronary CT, was included as a control group (n = 55). Laboratory index levels were collected from each participant. The baseline information was reviewed and analyzed. The binary logistic regression was used to explore the relation of ST2 levels with the occurrence of ACS and NSTEMI, and the diagnostic performance of ST2 for diagnosing ACS or NSTEMI was evaluated using a receiver‐operating characteristic (ROC) curve.ResultsThe level of ST2 was found significantly higher in NSTEMI than in USAP and was higher in USAP than in control (p < 0.01). ST2 levels were positively correlated with ALT, AST, and BNP in the control group, were negatively correlated with HGB and TG in the USAP group, and were positively correlated with WBC, GLU, BNP, and Gensini scores in the NSTEMI group. Multivariate analysis revealed that the occurrence of ACS was associated with ST2, BNP, GLU, TC, BUN, WBC, and PLT, and the occurrence of NSTEMI was associated with AST, WBC, LDL‐C, and ST2. Meanwhile, ST2 levels achieved good performance for ACS and NSTEMI diagnostician.ConclusionST2 could be used as an auxiliary diagnostic indicator for the occurrence of ACS and NSTEMI.
The effects of sustained COVID‐19 emergency and restrictions on the mental health of subjects with serious mental illness: A prospective study
Authors: Barone Annarita , Billeci Martina , D'Amore Sofia , De Prisco Michele , De Simone Giuseppe , Ermini Eleonora , Freda Vittorio , Iannotta Federica , Luciani Adalgisa , Pistone Luca , Rifici Lorenza M. , Saia Viviana M. , Spennato Giancarlo , Subosco Francesco , Vellucci Licia , D'Urso Giordano , Galletta Diana , Fornaro Michele , Iasevoli Felice , de Bartolomeis Andrea 
Published: May 2022

AbstractFew longitudinal studies have so far investigated the impact of sustained COVID‐19 among people with pre‐existing psychiatric disorders. We conducted a prospective study involving people with serious mental illness (n = 114) and healthy controls (n = 41) to assess changes in the Perceived Stress Scale, Generalized Anxiety Disorder Scale, Patient Health Questionnaire, and Specific Psychotic Experiences Questionnaire scores 18 months after the COVID‐19 pandemic outset. Subjects underwent interviews with a mental health professional in April 2020 and at the end of the local third wave (October 2021). A significant increase in perceived stress was found in healthy controls, especially females. Psychiatric patients showed a significant worsening of anxiety symptoms compared to baseline records (t = −2.3,p = 0.036). Patients who rejected vaccination had significantly higher paranoia scores compared to those willing to get vaccinated (U = 649.5,z = −2.02,p = 0.04). These findings indicate that COVID‐19's sustained emergency may cause enduring consequences on mental health, soliciting further investigations.
Integrating genetic assistants into the workforce: An 18‐year productivity analysis and development of a staff mix planning tool
Authors: Krutish Angela , Balshaw Robert F. , Jiang Xuejing , Hartley Jessica N. 
Published: May 2022

AbstractIn recent years, genetic (counseling) assistants have been integrated in the genetics workforce, such that one‐third of genetic counselors now report working with a genetic assistant. While several studies showed that adoption of the genetic assistant model leads to an increase in patient volume, the impact of this role substitution has not been studied quantitatively beyond the cancer genetics workforce. This study utilized 18 years of data from a publicly funded genetics clinic with multiple specialties and varying staff mix. Time series regression modeling was applied to describe the evolving impact of genetic assistants on genetic counselor and clinical geneticist productivity (measured as patient volume). The regression models suggest that the integration of genetic assistants led to a sustainable increase in genetic counselor patient volume, while clinical geneticist patient volume was unaffected. Importantly, the models also demonstrated an interaction between the number of genetic counselors and genetic assistants, whereby the impact of adding a genetic counselor was greater as more genetic assistants were employed in the clinic, and vice versa. The main regression model was used to create “ClinMix: A Genetics Staff Mix Planning Tool,” an Excel application that allows users to explore how different staffing plans could affect patient volume, by applying the parameters estimated from this data or their own. We hope this report and the ClinMix tool can be employed by the genetics workforce to advocate for further implementation and evaluation of genetic assistant positions. Adoption of the genetic assistant model may provide clinics the support needed to meet increasing service delivery demands and subsequently foster genetic counselor practice at “top of scope.”
Coupled Model Intercomparison Project phase 5 and 6 representation of peak and end of rainy season over Upper Blue Nile basin
Authors: Fetene Zewdu Alamineh , Zaitchik Benjamin F. , Zeleke Tadesse Terefe , Yeshita Baylie Damtie , Vashisht Amandeep 
Published: May 2022

AbstractThe Upper Blue Nile river basin (uBN) is vital to three countries' water, food, and energy security (Ethiopia, Sudan, and Egypt). It is also a region with substantial interannual precipitation variability and the potential for significant climate change in coming decades. The El Niño–Southern Oscillation (ENSO) affects both variability and trends in uBN precipitation, with El Niño episodes historically connected with below‐average rainfall. In this context, this study seeks to: (a) examine the representation of ENSO–uBN rainfall teleconnections in simulations from the sixth Coupled Model Intercomparison Project (CMIP6), as compared to the previous generation of models (CMIP5); (b) distinguish between teleconnections during the peak of the rainy season (July–August [JA]) and the agriculturally critical end‐of‐season rains (September–October [SO]); (c) investigate evidence for Tropical Easterly Jet (TEJ) mediation of these teleconnections in CMIP6 versus CMIP5 and for both peak rains and end of the rainy season. Using a subset of high performing models, we find that CMIP6 simulations of uBN precipitation show somewhat less bias than CMIP5 for JA total rainfall, and that correlations with ENSO have become more consistent across models, but that differences between CMIP5 and CMIP6 are modest. CMIP6 simulations, like CMIP5, overestimate SO rainfall and suggest a stronger ENSO association in SO than is indicated by observations. Model representation of the TEJ and its association with both ENSO and uBN precipitation show no systematic change between CMIP5 and CMIP6. The mediating influence of the TEJ appears to be more important in JA than SO.