bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Accuracy Transmission and Recognition of Complex Images through Multimode Fibers Using Deep Learning
Authors: Xu Runchu , Zhang Leihong , Chen Ziyang , Wang Zhiyuan , Zhang Dawei 
Published: November 2022

AbstractMultimode fiber shows tremendous potential in promoting the microminiaturization of optical endoscopes. However, multimode transmission is quite sensitive to fiber deformations and environmental changes. High‐accuracy transmission of complex images through a multimode fiber using traditional methods remains challenging research. Deep learning, which shows enormous vitality in optical imaging, may break through this limitation. Here, a deep neural network: U‐architecture speckles imaging network (USINET) is presented to realize high accuracy reconstruction of complex images under different multimode fiber transmission conditions. Furthermore, a shallow neural network: convolutional neural network (CNN)‐architecture speckles recognition network (CSRNET) is designed to realize high accuracy recognition for multiple categories of speckles at the output of multimode fiber under different bending states. The experimental results demonstrate that the proposed networks can realize high accuracy transmission and recognition of complex images through multimode fibers, which indicates the application prospect of multimode fibers combined with deep learning in minimally invasive medicine.
ALA‐PDT regulates macrophage M1 polarization via ERK/MAPK‐NLRP3 pathway to promote the early inflammatory response
Authors: Wang Liqun , Zhang Wentao , Cen Ruiyan , Yue Chenda , Xiao Tianzhen , Deng Yumeng , Li Lingfei , Sun Kedai , Lei Xia 
Published: November 2022

AbstractBackgroundPhotodynamic therapy (PDT) is a promising new approach to promote wound healing and its effectiveness has been demonstrated in both clinical and animal studies. Macrophages are the key cells in wound healing and inflammatory response. However, the mechanism of action of PDT on macrophages in promoting wound healing is still unclear.MethodsIn this study, RAW264.7 cells were used. We analyzed the expression levels of macrophage markers arginase 1 (Arg‐1), CD206, iNOS, CD86, and inflammatory factors IL‐6, TNF‐α, and IL‐1β by reverse transcription‐polymerase chain reaction and Western blot, Milliplex microtubule‐associated protein multiplex assay was performed to analyze the expression of inflammatory factors in the supernatant. Live cell Imaging System to observe the dynamic process of macrophage phagocytosis. Western blot was performed to observe the activation of extracellular signal‐regulated kinase/mitogen‐activated protein kinase (ERK/MAPK) and NOD‐like receptor protein 3 (NLRP3) inflammasome.Results5‐Aminolevulinic acid (ALA)‐PDT increased the expression of M1 marker iNOS/CD86 and decreased the expression of Arg‐1/CD206 in RAW264.7 cells, while, proinflammatory factors IL‐6, TNF‐α, and IL‐1β expression was enhanced and macrophage phagocytosis was increased. We also found that these phenomena were associated with activation of the ERK/MAPK‐NLRP3 pathway.ConclusionALA‐PDT promotes early inflammatory responses by regulating macrophage M1 polarization through the ERK/MAPK‐NLRP3 pathway. It also promotes macrophage phagocytosis.
The RISE FOR HEALTH study: Methods for in‐person musculoskeletal assessment
Authors: Fitzgerald Colleen M. , Fok Cynthia , Kenton Kim , Lukacz Emily , Markland Alayne D. , Meister Melanie , Newman Diane K. , Rudser Kyle , Smith Elia G. , Wyman Jean F. , Lowder Jerry L. ,   for the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium
Published: November 2022

AbstractObjectivesTo describe the methods for the in‐person musculoskeletal (MSK) assessment of the RISE FOR HEALTH (RISE) study, a population‐based multicenter prospective cohort study designed to identify factors associated with bladder health (BH) conducted by the Prevention of Lower Urinary Tract Symptoms Research Consortium (PLUS).MethodsA subset of RISE participants who express interest in the in‐person assessment are screened to ensure eligibility (planned n = 525). Eligible consenting participants are asked to complete a standardized MSK assessment to evaluate core stability (four component core stability test, lumbar spine pain (seated slump test), pelvic girdle pain, (sacroiliac joint, anterior superior iliac spine, pubic symphysis tenderness, and pelvic girdle pain provocation test), hip pain (flexion, abduction, internal rotation and flexion, adduction and external rotation) and pelvic girdle function (active straight leg raise). Participants are also asked to complete the Short Physical Performance Battery to measure balance, gait speed, lower extremity strength, and functional capacity.ResultsDetailed online and in‐person MSK training sessions led by physical therapy were used to certify research staff at each clinical center before the start of RISE in‐person assessments. All evaluators exceeded the pre‐specified pass rates.ConclusionsThe RISE in‐person MSK assessment will provide further insight into the role of general body MSK health and dysfunction and the spectrum of BH.
Feminizing gender‐affirming hormone therapy for the transgender and gender diverse population: An overview of treatment modality, monitoring, and risks
Authors: Sudhakar Deepshika , Huang Zhong , Zietkowski Maeson , Powell Natasha , Fisher Andrew R. 
Published: November 2022

AbstractAimsFeminizing gender‐affirming hormone therapy (GAHT) can be utilized to help transfeminine transgender and gender diverse (TGD) individuals achieve the transformation of outward sex characteristics, thereby leading to improvements in psychological and social well‐being. In this narrative review, we aim to summarize current guidelines for feminizing GAHT management as well as the available literature describing the associated health risks pertaining to cardiovascular disease, thromboembolic disease, bone health, and cancer risks.MethodsRelevant literature from January 2019 through July 2022 pertaining to feminizing GAHT was identified using PubMed, Cochrane Library, EMBASE, and MEDLINE. A narrative summary was performed with the inclusion of more recently published guidance from the World Professional Association for Transgender Health, Standards of Care Version 8.ResultsGuidance regarding the prescribing of feminizing GAHT with estrogen, antiandrogen, and progesterone medications is summarized along with considerations of the cardiovascular, thromboembolic, bone health, and cancer risks associated with these therapies.ConclusionsFeminizing GAHT is a highly effective method for transfeminine TGD patients to achieve medically necessary changes in secondary sex characteristics. Knowledge of the health risks of feminizing GAHT is largely drawn from research in the cisgender population, with a growing body of literature in TGD‐specific patient populations. Feminizing GAHT appears to carry a low risk profile for most patients; however, further research describing the risks of hormone management around the time of gender‐affirming surgery and in the aging TGD population is needed to optimize GAHT in the context of the evolving health risks over a TGD patient's lifespan.
Updates on metoidioplasty
Authors: Stojanovic Borko , Djordjevic Miroslav L. 
Published: November 2022

AbstractAimsMetoidioplasty presents a variant of phalloplasty in transmen who require simple and safe genital gender affirmation surgery (GAS). The aim is to evaluate updates on the technique, as well as personal experience.MethodsThe surgical steps of metoidioplasty are removal of the vagina, clitoral straightening and lengthening, urethral lengthening using available flaps and grafts, and creation of the scrotum with testicular prostheses implantation. The surgical goal is to achieve appearance of male genitalia, voiding in standing position, and full erogenous sensitivity. Modifications of the technique have developed due to recent advances in anatomy and new requests from transmen. Besides full metoidioplasty, other variants include metoidioplasty before, after or simultaneously with total phalloplasty. Each variant has its' own advantages, which must be discussed with the candidate preoperatively.ResultsA total of 938 transmen with the mean age of 29 years underwent one‐stage metoidioplasty between January 2004 and January 2022. In majority of cases (65%) metoidioplasty was performed as a final option, and the length of the neophallus ranged between 4 and 10 cm. Urethral complications occurred in 143 cases, dislocation and rejection of testicular implant in 55 and vaginal remnant in 92 cases. Voiding in standing position was reported in almost all cases (99%), and 12.5% of transmen requested phalloplasty after metoidioplasty.ConclusionMetoidioplasty is a safe, one‐stage procedure with good esthetic and functional outcomes. It includes a wide spectrum of variants that can be offered to transmen as a part of genital reconstruction, with goal of achieving patients' satisfaction.
Instruments assessing nurse educator's competence: A scoping review
Authors: Lemetti Terhi , Pakarinen Anni , Salminen Leena , Virtanen Heli , Haapa Toni 
Published: November 2022

AbstractAimThe aim of this review was to synthesize the instruments that assess nurse educators' competence.DesignA scoping review was conducted with the five‐stage process informed by Arksey and O'Malley.Review MethodsThe predetermined search strategy was used including an additional hand search. The studies were selected according to inclusion and exclusion criteria to answer the research questions followed: (1) “What instruments are used to assess nurse educators' competence?”, (2) “How are the psychometric properties of nurse educators' competence instruments reported in the literature?”. The thematic synthesis was used.Data SourcesThe literature search was conducted in January 2021 using the CINAHL, MEDLINE and ERIC databases from January 2000 to December 2020.ResultsOf the 1,567 articles searched through, 25 met the inclusion criteria. A total of 19 instruments with 10 areas of competence were identified. Typical competence areas were pedagogical and nursing competence. In addition, leadership in managerial competence was included in several instruments. However, the theoretical backgrounds of the instruments varied and the psychometric properties were reported in varied ways in reviewed studies.Implications for the ProfessionThis study provides evidence about the valid and comprehensive assessment of nurse educators' competence, as competent nurse educators promote excellence in nursing education. To assess a nurse educators' competence comprehensively, a variety of theoretical backgrounds of this competence and more than one instrument for the measurement need to be considered. The selection of the instruments to assess nurse educators' competence should be based on the selected theoretical background and use of valid measurements.Reporting MethodThis study was reported by following the reporting recommendations of the PRISMA extension for Scoping Reviews (PRISMA‐ScR).Patient or Public ContributionNo Patient or Public Contribution was applied, since research design was a scoping review.
Work engagement, emotional disorders and conflict management styles in paediatric nurse: A mediating effect model
Authors: Zhang Lijuan , Bu Pingyuan , Liu Haiyan 
Published: November 2022

AbstractAimThe mediating role of emotional disorders between conflict management styles and work engagement was explored based on constructing structural equation models in paediatric nurses.DesignA cross‐sectional study.MethodsAccording to a cross‐sectional survey, 300 paediatric nurses were selected from three tertiary hospitals (Chang sha, China), the data were collected using demographic questionnaires, the Rahim Organizational Conflict Inventory‐II, Depression, Anxiety and Stress Scales and the Utrecht Work Engagement Scale. The Structural Equation Model was employed to investigate the mediating role of emotional disorders between conflict management styles and work engagement.ResultsAmong conflict management styles, emotional disorders and work engagement, the associations were all significant (p < .05). In the mediation models, emotional disorders partially mediate the relationships between conflict management styles and work engagement (indirect effect 0.095, p < .01; direct effect −0.330, p < .01; total effect −0.330, p < .01) and between conflict management styles and work engagement (indirect effect 0.095, p < .01; direct effect 0.329, p < .01; total effect 0.424, p < .01).
“Opening up a well of emotions”: A qualitative study of men's emotional experiences in the transition to fatherhood
Authors: Solberg Beate , Glavin Kari , Berg Rigmor C. , Olsvold Nina 
Published: November 2022

AbstractAimTo explore the emotional changes and reactions men experience in their transition to fatherhood.DesignThis study used a qualitative design.MethodsData were collected through in‐depth interviews with 13 Norwegian fathers.ResultsThrough thematic analysis, three main themes were developed: (1) from self‐focus to family perspective; (2) emotional vulnerability; and (3) from insecurity to self‐assurance. The themes describe fathers' emotional process during the child's first year of life, ranging from positive feelings like affection and mastery, to challenging feelings like exclusion, jealousy and exhaustion. Many fathers describe taboos and shame over their own emotional reactions, although these can be considered a natural part of the postnatal period.
Psychometric testing of the facilitative student–patient relationship scale within six EUROPEAN countries
Authors: Suikkala Arja , Koskinen Sanna , Brasaitė‐Abromė Indrė , Fuster‐Linares Pilar , Lehwaldt Daniela , Leino‐Kilpi Helena , Meyer Gabriele , Sveinsdóttir Herdís , Katajisto Jouko ,   the ProCompNurse Consortium
Published: November 2022

AbstractAimThe aim of the study was to test the psychometric properties of the Facilitative Student–Patient Relationship (FSPR) Scale in clinical practicum in hospital settings within six European countries.DesignA multi‐country, cross‐sectional survey design was applied.MethodsA convenience sample of graduating nursing students (N = 1,796) completed the FSPR Scale. Psychometric testing was carried out through explorative factor analysis and confirmatory factor analysis. Internal consistency was assessed using Cronbach's alpha.ResultsBoth validity and reliability of the scale were confirmed. The explorative factor analysis yielded a two‐factor construct explaining 47.7% of the total variance, identifying two sub‐scales: caring relationship and learning relationship. Confirmatory factor analysis confirmed the two‐factor structure. The Cronbach alpha coefficients (0.8–0.9) indicated acceptable reliability of the scale.
Relatives' experiences of brief admission in borderline personality disorder and self‐harming behaviour
Authors: Hultsjö Sally , Rosenlund Hanna , Wadsten Lisa , Wärdig Rikard 
Published: November 2022

AbstractAimThe aim of this study is to describe experiences of brief admission (BA) of people with borderline personality disorder and self‐harming behaviour, from the perspective of their relatives.DesignA descriptive qualitative design was chosen.MethodsTwelve relatives of people with borderline personality disorder and self‐harming behaviour who had access to BA were interviewed. Data were analysed with qualitative conventional content analysis.ResultsOne overarching category: Hope for the future and three categories occurred: Breathing space, Personal responsibility and Structure. BA created hope for the future and the relatives appreciated that BA is a freer and easily accessible form of care that enables help at an early stage, compared with usual care. When BA functions, the structure and pre‐determined days of care give relatives a breathing space, and the uncertainty diminishes for the children, as the parent can still be present during inpatient care. The lack of places was described as a disadvantage of BA.
Effect of self‐management intervention on prognosis of patients with chronic heart failure: A meta‐analysis
Authors: Feng Chunqian , Wang Yanmei , Li Shuang , Qu Zhi , Zheng Shanqing 
Published: November 2022

AbstractAimThe purpose of this study is to explore the influence of self‐management intervention on four prognostic indicators of readmission rate, mortality rate, self‐management ability and quality of life in patients with chronic heart failure.DesignA meta‐analysis.MethodsThis study was selected from the related studies published from January 1999 to January 2022, and was searched by searching five databases: PubMed, Science of Website, China National Knowledge Infrastructure (CNKI), Wan Fang and Wei Pu (VIP). All standardized randomized controlled trial studies were collected, and the quality evaluation and meta‐analysis of the included literature were conducted.ResultsThis study included 20 randomized controlled trials involving 3459 patients with chronic heart failure. Meta‐analysis results showed that self‐management intervention could reduce the readmission rate of patients with chronic heart failure, improved self‐management ability of patients, improved quality of life, but there was no statistical significance in mortality.
Copy number variations analysis in a cohort of 47 fetuses and newborns with congenital diaphragmatic hernia
Authors: Boisson Marie , Cordier Anne‐Gael , Martinovic Jelena , Receveur Aline , Mouka Aurélie , Diot Romain , Egoroff Catherine , Esnault Geoffroy , Drévillon Loïc , Benachi Alexandra , Tachdjian Gérard , Tosca Lucie 
Published: November 2022

AbstractObjectivesThe congenital diaphragmatic hernia (CDH), characterized by malformation of the diaphragm and lung hypoplasia, is a common and severe birth defect that affects around 1 in 4000 live births. However, the etiology of most cases of CDH remains unclear. The aim of this study was to perform a retrospective analysis of copy number variations (CNVs) using a high‐resolution array comparative genomic hybridization (array‐CGH) in a cohort of fetuses and newborns with CDH.MethodsForty seven fetuses and newborns with either isolated or syndromic CDH were analyzed by oligonucleotide‐based array‐CGH Agilent 180K technique.ResultsA mean of 10.2 CNVs was detected by proband with a total number of 480 CNVs identified based on five categories: benign, likely benign, of uncertain signification, likely pathogenic, and pathogenic. Diagnostic performance was estimated at 19.15% (i.e., likely pathogenic and pathogenic CNVs) for both CDH types. We identified 11 potential candidate genes: COL25A1, DSEL, EYA1, FLNA, MECOM, NRXN1, RARB, SPATA13, TJP2, XIRP2, and ZFPM2.ConclusionWe suggest that COL25A1, DSEL, EYA1, FLNA, MECOM, NRXN1, RARB, SPATA13, TJP2, XIRP2, and ZFPM2 genes may be related to CDH occurrence. Thus, this study provides a possibility for new methods of a positive diagnosis.
Prenatal phenotyping of fetal tubulinopathies: A multicenter retrospective case series
Authors: Brar Bobby K. , Thompson Marisa Gilstrop , Vora Neeta L. , Gilmore Kelly , Blakemore Karin , Miller Kristen A. , Giordano Jessica , Dufke Andreas , Wong Beatrix , Stover Samantha , Lianoglou Billie , Van den Veyver Ignatia , Dempsey Esther , Rosner Mara , Chong Karen , Chitayat David , Sparks Teresa N. , Norton Mary E. , Wapner Ronald , Baranano Kristin , Jelin Angie C. ,   Fetal Sequencing Consortium
Published: November 2022

AbstractObjectiveTubulinopathies refer to conditions caused by genetic variants in isotypes of tubulin resulting in defective neuronal migration. Historically, diagnosis was primarily via postnatal imaging. Our objective was to establish the prenatal phenotype/genotype correlations of tubulinopathies identified by fetal imaging.MethodsA large, multicenter retrospective case series was performed across nine institutions in the Fetal Sequencing Consortium. Demographics, fetal imaging reports, genetic screening and diagnostic testing results, delivery reports, and neonatal imaging reports were extracted for pregnancies with a confirmed molecular diagnosis of a tubulinopathy.ResultsNineteen pregnancies with a fetal tubulinopathy were identified. The most common prenatal imaging findings were cerebral ventriculomegaly (15/19), cerebellar hypoplasia (13/19), absence of the cavum septum pellucidum (6/19), abnormalities of the corpus callosum (6/19), and microcephaly (3/19). Fetal MRI identified additional central nervous system features that were not appreciated on neurosonogram in eight cases. Single gene variants were reported in TUBA1A (13), TUBB (1), TUBB2A (1), TUBB2B (2), and TUBB3 (2).ConclusionThe presence of ventriculomegaly with cerebellar abnormalities in conjunction with additional prenatal neurosonographic findings warrants additional evaluation for a tubulinopathy. Conclusive diagnosis can be achieved by molecular sequencing, which may assist in coordination, prognostication, and reproductive planning.
Positive predictive values and outcomes for uninformative cell‐free DNA tests: An Italian multicentric Cytogenetic and cytogenomic Audit of diagnOstic testing (ICARO study)
Authors: Grati Francesca Romana , Bestetti Ilaria , De Siero Daria , Malvestiti Francesca , Villa Nicoletta , Sala Elena , Crosti Francesca , Parisi Valentina , Nardone Anna Maria , Di Giacomo Gianluca , Pettinari Antonella , Tortora Giada , Montaldi Annamaria , Calò Annapaola , Saccilotto Donatella , Zanchetti Sara , Celli Paola , Guerneri Silvana , Silipigni Rosamaria , Cardarelli Laura , Lippi Elisabetta , Cavani Simona , Malacarne Michela , Genesio Rita , Beltrami Nicola , Pittalis Maria Carla , Desiderio Laura , Gentile Mattia , Ficarella Romina , Recalcati Maria Paola , Catusi Ilaria , Garzo Maria , Miele Lorena , Corti Cecilia , Ghezzo Sara , Bertini Veronica , Cambi Francesca , Valetto Angelo , Facchinetti Barbara , Bernardini Laura , Capalbo Anna , Balducci Federica , Pelo Elisabetta , Minuti Barbara , Pescucci Chiara , Giuliani Costanza , Renieri Alessandra , Longo Ilaria , Tita Rossella , Castello Giuseppe , Casalone Rosario , Righi Rossana , Raso Barbara , Civolani Alessandro , Muzi Maria Cristina , di Natale Manuela , Varriale Luigia , Gasperini Daniela , Nuzzi Maria Cristina , Cellamare Angelo , Casieri Paola , Busuito Rosa , Ceccarini Caterina , Cesarano Carla , Privitera Orsola , Melani Daniela , Menozzi Cristina , Falcinelli Cristina , Calabrese Olga , Battaglia Paola , Tanzariello Antonella , Stampalija Tamara , Ardisia Carmela , Gasparini Paolo , Benn Peter , Novelli Antonio 
Published: November 2022

AbstractObjectivesTo establish the positive predictive values (PPV) of cfDNA testing based on data from a nationwide survey of independent clinical cytogenetics laboratories.MethodsPrenatal diagnostic test results obtained by Italian laboratories between 2013 and March 2020 were compiled for women with positive non‐invasive prenatal tests (NIPT), without an NIPT result, and cases where there was sex discordancy between the NIPT and ultrasound. PPV and other summary data were reviewed.ResultsDiagnostic test results were collected for 1327 women with a positive NIPT. The highest PPVs were for Trisomy (T) 21 (624/671, 93%) and XYY (26/27, 96.3%), while rare autosomal trisomies (9/47, 19.1%) and recurrent microdeletions (8/55, 14.5%) had the lowest PPVs. PPVs for T21, T18, and T13 were significantly higher when diagnostic confirmation was carried out on chorionic villi (97.5%) compared to amniotic fluid (89.5%) (p < 0.001). In 19/139 (13.9%), of no result cases, a cytogenetic abnormality was detected. Follow‐up genetic testing provided explanations for 3/6 cases with a fetal sex discordancy between NIPT and ultrasound.ConclusionsNIPT PPVs differ across the conditions screened and the tissues studied in diagnostic testing. This variability, issues associated with fetal sex discordancy, and no results, illustrate the importance of pre‐ and post‐test counselling.