bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile synthesis and characterisations of cobalt ferrite-silver-graphene oxide nanocomposite in enhancing electrochemical response capacity
Authors: Hoang Van-Tuan , Le Nhat Trang Nguyen , Thi Nguyet Nga Dao , Ngo Xuan-Dinh , Pham Tuyet Nhung , Tran Van Tan , Mai Mai , Thi Tam Le , Tri Doan Quang , Le Anh-Tuan 
Published: July 2022

Abstract
In this report, cobalt ferrite nanoparticles (CoFe2O4 NPs) synthesised from the co-precipitation method were strongly connected with graphene oxide nanosheets (GO) via ‘bridge molecules’- polyhexamethylene biguanide hydrochloride (PHMB)’. Silver (Ag) NPs were grown on the surface of CoFe2O4-GO nanocomposites to improve the electrical conductivity and electrocatalytic ability of the proposed functional nanocomposites. Characteristics of the synthesised materials were investigated via x-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, cyclic voltammetry (CV), and differential pulse voltammetry (DPV). The obtained results demonstrate that the CoFe2O4-Ag-GO nanocomposites could significantly improve the adsorption ability and electron transfer between electrode and analytes owing to the synergetic effect of Ag NPs, CoFe2O4 NPs, and GO. The prepared CoFe2O4-Ag-GO nanocomposites showed the highest electrochemical response for chloramphenicol antibiotic detection, with current intensity response (∼24.4 μA) being 3.25 and 2.57 times higher than that of CoFe2O4 NPs (7.5 μA) and CoFe2O4-GO (9.5 μA), respectively. The calibration plot is linear in the 1–50 μM CAP concentration range, with a detection limit of 0.1 μM. With excellent electrochemical properties, the CoFe2O4-Ag-GO nanocomposites are expected to be a potential candidate for advanced electrochemical sensing applications.
TargetMine 2022: a new vision into drug target analysis
Authors: Chen Yi-An , Allendes Osorio Rodolfo S , Mizuguchi Kenji 
Published: July 2022

AbstractSummaryWe introduce the newest version of TargetMine, which includes the addition of new visualization options; integration of previously disaggregated functionality; and the migration of the front-end to the newly available Bluegenes service.Availability and ImplementationTargeteMine is accessible online at https://targetmine.mizuguchilab.org/bluegenes. Users do not need to register to use the software. Source code for the different components listed in the article is available from TargetMine’s organizational account at http://github.com/targetmine.Supplementary informationSupplementary data are available at Bioinformatics online.
Expedited epilepsy surgery prior to drug resistance in children: a frontier worth crossing?
Authors: Hale Andrew T , Chari Aswin , Scott Rod C , Helen Cross J , Rozzelle Curtis J , Blount Jeffrey P , Tisdall Martin M 
Published: July 2022

Abstract
Epilepsy surgery is an established safe and effective treatment for selected candidates with drug-resistant epilepsy. In this opinion piece, we outline the clinical and experimental evidence for selectively considering epilepsy surgery prior to drug resistance. Our rationale for expedited surgery is based on the observations that (i) a high proportion of patients with lesional epilepsies (e.g. focal cortical dysplasia, epilepsy-associated tumours) will progress to drug resistance; (ii) surgical treatment of these lesions, especially in non-eloquent areas of brain, is safe; and (iii) earlier surgery may be associated with better seizure outcomes. Potential benefits beyond seizure reduction or elimination include less exposure to antiseizure medications, which may lead to improved developmental trajectories in children and optimize long-term neurocognitive outcomes and quality of life. Further, there exists emerging experimental evidence that brain network dysfunction exists at the onset of epilepsy, where continuing dysfunctional activity could exacerbate network perturbations. This in turn could lead to expanded seizure foci and contribution to the comorbidities associated with epilepsy. Taken together, we rationalize that epilepsy surgery, in carefully selected cases, may be considered prior to drug resistance. Last, we outline the path forward, including the challenges associated with developing the evidence base and implementing this paradigm into clinical care.
Transfusion-Transmitted Cache Valley Virus Infection in a Kidney Transplant Recipient With Meningoencephalitis
Authors: Al-Heeti Omar , Wu En-Ling , Ison Michael G , Saluja Rasleen K , Ramsey Glenn , Matkovic Eduard , Ha Kevin , Hall Scott , Banach Bridget , Wilson Michael R , Miller Steve , Chiu Charles Y , McCabe Muniba , Bari Chowdhury , Zimler Rebecca A , Babiker Hani , Freeman Debbie , Popovitch Jonathan , Annambhotla Pallavi , Lehman Jennifer A , Fitzpatrick Kelly , Velez Jason O , Davis Emily H , Hughes Holly R , Panella Amanda , Brault Aaron , Staples J Erin , Gould Carolyn V , Tanna Sajal 
Published: July 2022

Abstract

Background
Cache Valley virus (CVV) is a mosquito-borne virus that is a rare cause of disease in humans. In the fall of 2020, a patient developed encephalitis 6 weeks following kidney transplantation and receipt of multiple blood transfusions.

Methods
After ruling out more common etiologies, metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) was performed. We reviewed the medical histories of the index kidney recipient, organ donor, and recipients of other organs from the same donor and conducted a blood traceback investigation to evaluate blood transfusion as a possible source of infection in the kidney recipient. We tested patient specimens using reverse-transcription polymerase chain reaction (RT-PCR), the plaque reduction neutralization test, cell culture, and whole-genome sequencing.

Results
CVV was detected in CSF from the index patient by mNGS, and this result was confirmed by RT-PCR, viral culture, and additional whole-genome sequencing. The organ donor and other organ recipients had no evidence of infection with CVV by molecular or serologic testing. Neutralizing antibodies against CVV were detected in serum from a donor of red blood cells received by the index patient immediately prior to transplant. CVV neutralizing antibodies were also detected in serum from a patient who received the co-component plasma from the same blood donation.

Conclusions
Our investigation demonstrates probable CVV transmission through blood transfusion. Clinicians should consider arboviral infections in unexplained meningoencephalitis after blood transfusion or organ transplantation. The use of mNGS might facilitate detection of rare, unexpected infections, particularly in immunocompromised patients.
Intradialytic parenteral nutrition for patients on hemodialysis: when, how and to whom?
Authors: Carrero Juan J , Severs David , Aguilera Didier , Fiaccadori Enrico , Gonzalez Martin G , Haufe Christoph C , Teta Daniel , Molina Pablo , Visser Wesley 
Published: July 2022

ABSTRACT
Hemodialysis is associated with high morbidity and mortality rates as well as low quality of life. Altered nutritional status and protein-energy wasting are important indicators of these risks. Maintaining optimal nutritional status in patients with hemodialysis is a critical but sometimes overlooked aspect of care. Nutritional support strategies usually begin with dietary counseling and oral nutritional supplements. Patients may not comply with this advice or oral nutritional supplements, however , or compliance may be affected by other complications of progressive chronic kidney disease. Intradialytic parenteral nutrition (IDPN) may be a possibility in these cases, but lack of knowledge on practical aspects of IDPN delivery are seldom discussed and may represent a barrier. In this review, we, as a consensus panel of clinicians experienced with IDPN, survey existing literature and summarize our views on when to use IDPN, which patients may be best suited for IDPN, and how to effectively deliver and monitor this strategy for nutritional support.
Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects
Authors: Carnovale Carla , Perrotta Cristiana , Baldelli Sara , Cattaneo Dario , Montrasio Cristina , Barbieri Silvia S , Pompilio Giulio , Vantaggiato Chiara , Clementi Emilio , Pozzi Marco 
Published: July 2022

AbstractA bidirectional relationship exists between hypertension and psychiatric disorders, including unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis, schizophrenia, mania, and dementia/cognitive decline. Repurposing of antihypertensive drugs to treat mental disorders is thus being explored. A systematic knowledge of the mechanisms of action and clinical consequences of the use of antihypertensive agents on neuropsychiatric functions has not been achieved yet. In this article, we review the putative role of antihypertensive agents in psychiatric disorders, discuss the targets and mechanisms of action, and examine how and to what extent specific drug classes/molecules may trigger, worsen, or mitigate psychiatric symptoms. In addition, we review pharmacokinetics (brain penetration of drugs) and pharmacogenetics data that add important information to assess risks and benefits of antihypertensive drugs in neuropsychiatric settings.The scientific literature shows robust evidence of a positive effect of α1 blockers on PTSD symptoms, nightmares and sleep quality, α2 agonists on core symptoms, executive function, and quality of life in Attention-Deficit/Hyperactivity Disorder, PTSD, Tourette’s syndrome, and β blockers on anxiety, aggression, working memory, and social communication. Renin-angiotensin system modulators exert protective effects on cognition, depression, and anxiety, and the loop diuretic bumetanide reduced the core symptoms of autism in a subset of patients. There is no evidence of clear benefits of calcium channel blockers in mood disorders in the scientific literature. These findings are mainly from preclinical studies; clinical data are still insufficient or of anecdotal nature and seldom systematic. The information herewith provided can support a better therapeutic approach to hypertension, tailored to patients with, or with high susceptibility to, psychiatric illness. It may prompt clinical studies exploring the potential benefit of antihypertensive drugs in selected patients with neuropsychiatric comorbidities that include outcomes of neuropsychiatric interest and specifically assess undesirable effects or interactions.
Estimating Cross-Industry Cross-Country Interaction Models Using Benchmark Industry Characteristics
Authors: Ciccone Antonio , Papaioannou Elias 
Published: July 2022

Abstract
Cross-industry cross-country models are used to address a wide array of questions in economics. They do so by analysing how the economic performance of industries in different countries depends on an interaction effect between industry and country characteristics. As the relevant industry characteristics are unobservable in most countries, they are approximated by industry characteristics in a benchmark country. We show that this approach generally yields biased estimates of the industry–country interaction effect. The sign of the bias depends on whether or not technologically similar countries tend to be similar in other country characteristics. We propose an alternative estimation approach.
Iatrogenic cardiac perforation due to pacemaker and defibrillator leads: a contemporary multicentre experience
Authors: Waddingham Peter H , Elliott James , Bates Alexander , Bilham James , Muthumala Amal , Honarbakhsh Shohreh , Ullah Waqas , Hunter Ross J , Lambiase Pier D , Lane Rebecca E , Chow Anthony W C 
Published: July 2022

Abstract

Aims
To determine the incidence, clinical features, management, and outcomes of pacemaker (PM) and implantable cardioverter-defibrillator (ICD) lead cardiac perforation. Cardiac perforations due to PM and ICD leads are rare but serious complications. Clinical features vary widely and may cause diagnostic delay. Management strategies are non-guideline based due to paucity of data.

Methods and results
A multicentre retrospective series including 3 UK cardiac tertiary centres from 2016 to 2020. Patient, device, and lead characteristics were obtained including 6-month outcomes. Seventy cases of perforation were identified from 10 631 procedures; perforation rate was 0.50% for local implants. Thirty-nine (56%) patients were female, mean ( ± standard deviation) age 74 ( ± 13.8) years. Left ventricular ejection fraction 51 ( ± 13.2) %. Median time to diagnosis was 9 (range: 0–989) days. Computed tomography (CT) diagnosed perforation with 97% sensitivity. Lead parameter abnormalities were present in 86% (whole cohort) and 98.6% for perforations diagnosed &gt;24 h. Chest pain was the commonest symptom, present in 46%. The management strategy was percutaneous in 98.6% with complete procedural success in 98.6%. Pericardial effusion with tamponade was present in 17% and was associated with significantly increased mortality and major complications. Anticoagulation status was associated with tamponade by multivariate analysis (odds ratio 21.7, 95% confidence interval: 1.7–275.5, P = 0.018).

Conclusions
Perforation was rare (0.50%) and managed successfully by a percutaneous strategy with good outcomes. Tamponade was associated with increased mortality and major complications. Anticoagulation status was an independent predictor of tamponade. Case complexity is highly variable and requires skilled operators with a multi-disciplinary approach to achieve good outcomes.
Comparative chemical genomic profiling across plant-based hydrolysate toxins reveals widespread antagonism in fitness contributions
Authors: Vanacloig-Pedros Elena , Fisher Kaitlin J , Liu Lisa , Debrauske Derek J , Young Megan K M , Place Michael , Hittinger Chris Todd , Sato Trey K , Gasch Audrey P 
Published: July 2022

AbstractThe budding yeast Saccharomyces cerevisiae has been used extensively in fermentative industrial processes, including biofuel production from sustainable plant-based hydrolysates. Myriad toxins and stressors found in hydrolysates inhibit microbial metabolism and product formation. Overcoming these stresses requires mitigation strategies that include strain engineering. To identify shared and divergent mechanisms of toxicity and to implicate gene targets for genetic engineering, we used a chemical genomic approach to study fitness effects across a library of S. cerevisiae deletion mutants cultured anaerobically in dozens of individual compounds found in different types of hydrolysates. Relationships in chemical genomic profiles identified classes of toxins that provoked similar cellular responses, spanning inhibitor relationships that were not expected from chemical classification. Our results also revealed widespread antagonistic effects across inhibitors, such that the same gene deletions were beneficial for surviving some toxins but detrimental for others. This work presents a rich dataset relating gene function to chemical compounds, which both expands our understanding of plant-based hydrolysates and provides a useful resource to identify engineering targets.
Characterization of the cluster MabR prophages of Mycobacterium abscessus and Mycobacterium chelonae
Authors: Cote Jacob , Welch Colin , Kimble Madeline , Archambault Dakota , Ross John Curtis , Orellana Hector , Amero Katelyn , Bourett Claire , Daigle Andre , Hutchison Keith W , Molloy Sally D 
Published: July 2022

Abstract
Mycobacterium abscessus is an emerging pathogen of concern in cystic fibrosis and immunocompromised patients and is considered one of the most drug-resistant mycobacteria. The majority of clinical Mycobacterium abscessus isolates carry 1 or more prophages that are hypothesized to contribute to virulence and bacterial fitness. The prophage McProf was identified in the genome of the Bergey strain of Mycobacterium chelonae and is distinct from previously described prophages of Mycobacterium abscessus. The McProf genome increases intrinsic antibiotic resistance of Mycobacterium chelonae and drives expression of the intrinsic antibiotic resistance gene, whiB7, when superinfected by a second phage. The prevalence of McProf-like genomes was determined in sequenced mycobacterial genomes. Related prophage genomes were identified in the genomes of 25 clinical isolates of Mycobacterium abscessus and assigned to the novel cluster, MabR. They share less than 10% gene content with previously described prophages; however, they share features typical of prophages, including polymorphic toxin–immunity systems.
Radiated seismic energy and source damage evolution from the analysis of simulated dynamic rupture and far-field seismograms
Authors: Kurzon Ittai , Lyakhovsky Vladimir , Sagy Amir , Ben-Zion Yehuda 
Published: July 2022

SUMMARYWe present results on radiated seismic energy during simulations of dynamic ruptures in a continuum damage-breakage rheological model incorporating evolution of damage within the seismic source region. The simulations vary in their initial damage zone width and rate of damage diffusion with parameter values constrained by observational data. The radiated energy recorded at various positions around the source is used to calculate seismic potency and moment. We also calculate the normalized radiated energy from the source, in a way that allows comparing between results of different simulations and highlighting aspects related to the dilatational motion during rupture. The results show that at high-frequencies, beyond the dominant frequency of the source ($( {f &gt; 3{f}_d} )$, the damage process produces an additional burst of energy mainly in the Pwaves. This eccess of high-frequency energy is observed by comparing the radiated energy to a standard Brune's model with a decay slope of the radiated energy of n = 2. While the Swaves show good agreement with the n = 2 slope, the Pwaves have a milder slope of n = 1.75 or less depending on the damage evolution at the source. In the used damage-breakage rheology, the rate of damage diffusivity governs the damage evolution perpendicular to the rupture direction and dynamic changes of the damage zone width. For increasing values of damage diffusivity, dilatational energy becomes more prominent during rupture, producing a high-frequency dilatational signature within the radiation pattern. The high-frequency radiation pattern of the Pwaves includes two main lobes perpendicular to the rupture direction, reflecting high-rate local tensile cracking during the overall shear rupture process. Analysing the possible existence and properties of such high-frequency radiation pattern in observed Pwaves could provide important information on earthquake source processes.
Three-dimensional Gauss–Newton constant-Q viscoelastic full-waveform inversion of near-surface seismic wavefields
Authors: Mirzanejad Majid , Tran Khiem T , Wang Yao 
Published: July 2022

SUMMARY
Full-waveform inversion (FWI) methods rely on accurate numerical simulation of wave propagation in the analysed medium. Acoustic or elastic wave equations are often used to model seismic wave propagation. These types of simulations do not account for intrinsic attenuation effects due to material anelasticity, and thus correction techniques have been utilized in practice to partially compensate the anelasticity. These techniques often only consider the waveform amplitude correction based on averaging of overall amplitude response over the entire data set, and ignore the phase correction. Viscoelastic wave equations account for the anelastic response in both waveform amplitude and phase, and are therefore a more suitable alternative. In this study, we present a novel 3-D Gauss–Newton viscoelastic FWI (3-D GN-VFWI) method. To address the main challenge of the Gauss–Newton optimization, we develop formulas to compute the Jacobian efficiently by the convolution of virtual sources and backward wavefields. The virtual sources are obtained by directly differentiating the viscoelastic wave equations with respect to model parameters. In order to resolve complex 3-D structures with reasonable computational effort, a homogeneous attenuation (Q factor) is used throughout the analysis to model the anelastic effects. Synthetic and field experiments are performed to demonstrate the utility of the method. The synthetic results clearly demonstrate the ability of the method in characterizing a challenging velocity profile, including voids and reverse velocity layers. The field experimental results show that method successfully characterizes the complex substructure with two voids and undulating limestone bedrock, which are confirmed by invasive tests. Compared to 3-D elastic FWI results, the presented viscoelastic method produces more accurate results regarding depths of the voids and bedrock. This study suggests that the improvement of imaging accuracy would warrant the widespread use of viscoelastic wave equations in FWI problems. To our best knowledge, this is the first reported study on 3-D GN-VFWI at any scale. This study provides the new theory and formulation for the use of Gauss–Newton optimization on the 3-D viscoelastic problem.
Movement, Space Use, and the Responses of Coral Reef Fish to Climate Change
Authors: Manning J C 
Published: July 2022

Abstract
Anthropogenic climate change and other localized stressors have led to the widespread degradation of coral reefs, characterized by losses of live coral, reduced structural complexity, and shifts in benthic community composition. These changes have altered the composition of reef fish assemblages with important consequences for ecosystem function. Animal movement and space use are critically important to population dynamics, community assembly, and species coexistence. In this perspective, I discuss how studies of reef fish movement and space use could help us to elucidate the effects of climate change on reef fish assemblages and the functions they provide. In addition to describing how reef fish space use relates to resource abundance and the intrinsic characteristics of reef fish (e.g., body size), we should begin to take a mechanistic approach to understanding movement in reef fish and to investigate the role of movement in mediating species interactions on coral reefs. Technological advances in animal tracking and biotelemetry, as well as methodological advances in the analysis of movement, will aid in this endeavor. Baseline studies of reef fish movement and space use and their effect on community assembly and species coexistence will provide us with important information for predicting how climate change will influence reef fish assemblages.