bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies on Immobilization and Activity of Peroxidase Based on Zr-based MOFs
Authors: Yang Linyan , Sun Hongliang , Liu Shuxuan , Li Shuang , Cai Zhipeng , Zhao Ruili , Jin Tianming 
Published: June 2022

Abstract
Metal-Organic Frameworks (MOFs) are a kind of porous crystalline compounds, which are self-assembled by metal clusters and organic ligands through coordination bonds. UiO66 is a kind of MOF crystal materials with a porous octahedral structure, which is coordinated by zirconium ion and terephthalic acid (H2BDC). In this paper, UiO66-NH2 and UiO66-(COOH)2 were prepared, and UiO66-NH2 was modified by Post-Synthetic Modification (PSM) to obtain UiO66-NH2-COOH material. The prepared samples and intermediate products were characterized by infrared spectrum (IR). UiO66-NH2-COOH and UiO66-(COOH)2 materials were loaded with horseradish peroxidase (HRP), which catalyzed the reaction between H2O2 and 3, 3', 5, 5'-tetramethylbenzidine (TMB). Via the results of UV-vis spectrophotometry measurement, it was found that UiO66-(COOH)2 loaded with HRP had better catalytic effects than only HRP. In order to verify the influence of carboxyl groups on UiO66-NH2-COOH and UiO66-(COOH)2 materials, the adsorption of rhodamine B (RhB) was studied in this paper. The results of fluorescence spectrophotometer showed that UiO66-NH2-COOH material had better adsorption effect on RhB than UiO66-(COOH)2 material, which may be attributed to the flexibility of UiO66-NH2-COOH material after PSM. UiO66-NH2-COOH and UiO66-(COOH)2 materials were characterized by X-ray powder diffraction (XRD) before and after adsorption of RhB. The XRD pattern of UiO66-(COOH)2 material has no obvious characteristic peak, which indicates that it belongs to nanoparticle polymer. The results are consistent with the UV-visible results, and the nanoparticle polymer has better catalytic effects.
Association of low dose p-phenylenediamine exposure with alterations of pulmonary function, pruritus and health-related quality of life in hair dye factory workers: a cross-sectional study
Authors: Zhang Ming , Fan Lin , Lin Dafeng , Zhang Meibian , Zhang Naixing 
Published: June 2022

Abstract
P-Phenylenediamine (PPD) is a common component of hair dye, which can cause skin contact allergy and asthma with impaired pulmonary function. However, the adverse effects of occupational exposure to low dose PPD was rarely mentioned. We recruited 124 workers from a hair dye factory to explore low dose PPD-induced pulmonary dysfunction, pruritus and health-related quality of life (HRQL). The quality of life and subjective pruritus of the workers was assessed by the short form 36 health survey (SF-36) and Visual analogue scale (VAS) of pruritus, respectively. In the high PPD-exposed group, FVC% (percentage of forced vital capacity) was higher, while FEV1/FVC% (ratio percentage of forced expiratory volume) was lower than that in the low PPD-exposed group (P<0.05). In terms of the HRQL, the scores of mental health and vitality in the higher exposure group were the lowest (P<0.05), while the score of VAS was significantly higher than that of other two groups (P<0.001). PPD levels were negatively correlated with vitality and mental health (P<0.01). The structural equation model showed that PPD have positive effects on VAS level (β = 0.213, P <0.001). Then PPD partly lacked total score of SF-36 (β = -0.465, P =0.002). Our results indicate that occupational exposure to low dose PPD might be associated with pulmonary function impairment, poor HRQL, and subjective pruritus of the workers.
The Relationship Between Accessory Maxillary Ostium and Sinonasal Region Variations
Authors: Okumuş Özlem , Şallı Gülay Altan 
Published: June 2022

Abstract
Purposes: The aim of this study is to evaluate the prevalence of accessory maxillary ostium (AMO) and its association with age, gender, sinus variation, pathological formations, status of dentition and tooth endodontic and periodontal status using cone-beam computed tomography (CBCT).Methods : The study examined archived CBCT images of 390 patients at least 18 years old (232 females and 158 males) representing 790 regions of interest. The mean age of the female patients was 46.35 and that of the males was 48.62. All the CBCT images analyzed with sagittal, coronal and axial sections. The data were assessed using IBM SPSS 22. Significance was evaluated at the p <0.05 level. Results: The study observed that while the prevalence of primary maxillary ostium (PMO) on the right side was 94.9% and on the left side was 94.6% (for a total of 94.7%), the prevalence of accessory ostium on the right side was 33.1% and on the left was 35.4% (34.2% in total).Conclusions: There was no significant difference in AMO prevalence related to age, presence of mucosal thickness, mucus retention cysts, maxillary sinusitis, sinonasal variation, status of dentition or periodontal status of posterior maxilla. However there was a relationship between AMO and both gender and endodontic status.
Multinomial logistic regression analysis of the determinants of anaemia severity among children aged 6-59 months in Ghana: New evidence from the 2019 Malaria Indicator Survey
Authors: Klu Desmond , Atiglo Donatus Yaw , Christian Aaron Kobina 
Published: June 2022

Abstract
BackgroundAnaemia among children under age five is a major public health issue. Although anaemia prevalence is declining in Ghana, the severity among anaemic children is worsening. This study aims to investigate the determinants of anaemia severity among children aged 6 to 59 months in Ghana.MethodThe study utilized data from 1,258 children with anaemia from the 2019 Malaria Indicator Survey. The independent variables included child, maternal, health, household and system characteristics. Analyses were conducted at the univariate, bivariate and multivariate levels. At the multivariate level, three different multinomial logistic models were run to include interactive terms between selected independent variables. All tests were conducted at the 95% confidence level.ResultsThe overall anaemia prevalence among children under age five was 43.5%. Of these, 2.6% were severely anaemic, and 48.5% and 48.9/5 had moderate and mild anaemia, respectively. The multinomial analysis showed that maternal, household, child and health system factors significantly predicted anaemia levels among children with anaemia. The results indicate that anemic children whose mothers reside in urban areas (AOR=3.87; C. I: 1.11-13.48), children whose mothers are unaware of NHIS coverage of malaria (AOR=3.00; C.: 1.31-6.88) were more likely to have severe anaemia. Again, a lower probability of being severely anaemic was found among anaemic children whose household heads were aged 30-39 years and children who tested negative for malaria. With regard to moderate anaemia level, children who belong to the poorest and poorer household wealth index had a higher likelihood of being moderately anaemic. Similarly, children with anaemia who were less than 12 months old (AOR=1.72; C. I: 1.06-2.80) and mothers of anaemic children who were not aware of NHIS coverage of malaria (AOR=1.33; C.I: 1.00-1.77) were more likely to have moderate anaemia levels. Furthermore, anemic children whose household heads were aged 50-59 years (AOR=0.52; CI: 0.29-0.93) and three-year-old anemic children (AOR=0.59; C.: 0.38-0.90) had a lower likelihood of being moderately anaemic.ConclusionThe study findings show the importance of understanding the interaction among factors that influence anaemia levels among children under age five as critical in developing strategies and programmes aimed at addressing childhood anaemia.
“Not just the consequences, but also the pleasurable sex”: a review of the content of comprehensive sexuality education for schooling early adolescents in Rwanda.
Authors: Mbarushimana Valens , Goldstein Susan , Conco Daphney Nozizwe 
Published: June 2022

Abstract
Background: Responding to adolescents' educational needs in sexual and reproductive health and rights is central to their sexual health. In 2016, Rwanda introduced the Competence-based curriculum (CBC) that integrated comprehensive sexuality education (CSE). However, globally, the content of CSE is sometimes dissimilar, and little evidence surrounds its scope in many settings. This study aimed to assess major topic areas of the school-based CSE for early adolescents, analyse how this CSE correlates with international guidelines, and make recommendations accordingly.Methods: We reviewed the CBC and conducted semi-structured interviews with key informants concerned with sexuality education to map sexuality education contents and related CSE competences for pre-primary, primary and lower secondary levels. We selected eleven of the 23 CBC documents for the final review. We manually extracted data using a standard form in Microsoft Excel. We conducted a descriptive analysis (frequency tables and charts) of review data and a thematically analysed interviews in NVivo 11 for Windows using the International Technical Guidance of Sexuality Education (ITGSE).Findings: Overall, we found 58 CSE competences from the CBC. CSE competences increased with school grades: 4/58 (6.9%) in pre-school, 5/58 (8.6%) in lower-primary, 17/58 (29.3%) in upper-primary, and 32/58 (55.2%) in lower-secondary levels. Subjects of Kinyarwanda (13/58, 22.4%), Biology (10/58, 17.2%), and Social studies (9/58, 15.5%) abounded in CSE. Four ITGSE key concepts abounded most in CSE competences: Sexual and reproductive health (13/58, 22.4%); Human body and development (11/58, 19%); Values, rights, and sexuality (9/58, 15.5%); and Understanding gender (8/58, 13.8%). The CBC CSE covered least the area of Violence and staying safe (2/58, 3.4%). Six of 27 ITGSE topics had only one CSE competence, and eight ITGSE topics were not represented in the CBC. Recommended additional contents are sexual pleasure, sexual orientation, sexual desire and modern contraceptive methods such as condoms.Conclusion: CSE for early adolescents is delivered mainly in three subjects and aligns, to some extent, with the international guidelines for sexuality education. CSE intensifies with school grades and emphasises more on some topics than others that are equally important. The study recommends additional topics for CSE for this age group.
Secondary systemic AL-amyloidosis associated with multiple myeloma: Clinical case and literature review
Authors: Novosad Olga , Rudiuk Tymur , Shevchuk Lesya , Kundina Viktoriia , Schmidt Anna 
Published: June 2022

Abstract
AL-amyloidosis refers to a systemic type of disease characterised by aggregation of an improperly folded light chain of immunoglobulin, mainly in the heart and kidneys, causing organ failure. This study describes the clinical experience of introducing a patient with cardiac amyloidosis associated with multiple myeloma. The diagnosis of amyloidosis is based on a high index of clinical suspicion. Unfortunately, the disease often proceeds asymptomatically until a late stage, and even then the symptoms can be very nonspecific. The prolonged time to establish a diagnosis, often more than 1 year, is a frequent factor in poor treatment results. The slow course of the disease, in most cases, leads to fatal consequences, since initially, patients do not turn to specialised professionals. Namely, congestive heart failure and cardiac arrhythmia are common causes of death from primary systemic amyloidosis, from 48% to 65% of cardiac mortality. More accurate recognition of AL-amyloidosis by cardiologists allows prescribing earlier treatment and improving results. Conventional treatment of multiple myeloma and AL-amyloidosis includes a combination of dexamethasone with bortezomib and endoxan. Hematopoietic stem cell transplantation after taking high doses of melphalan has become another treatment option and has led to remission in some patients. The study presents an example of a timely complete diagnosis and treatment of a combination of these two diseases, as a result of which the patient has achieved a complete haematological and partial organ response to the underlying disease.
Objective Identification and Characterisation of Pacific ITCZs using ERA5, GPCP and TRMM
Authors: Homoudi Ahmed , Barfus Klemens , Bedbur Gesa , Quesada-Chacón Dánnell , Bernhofer Christian 
Published: June 2022

Abstract
Despite the intense research on the tropical climate and its features, primarily the Intertropical Convergence Zone (ITCZ), fewer studies investigated the state of the ITCZ through an objective and automated algorithm, particularly the double ITCZ. The study combines the European Centre for Medium-Range Weather Forecasts Reanalysis (ERA5) variables, Global Precipitation ClimatologyProject (GPCP), and TRMM (TMPA 3B42 Daily) datasets to objectively and automatically identify the zonally elongated convergence regions (i.e. ITCZs) in the Pacific and provide 42 years climatologies. The algorithm utilises layer- and time-averaged winds in the lower troposphere (pressure levels between 1000 and 850 hPa) to obtain characteristics of ITCZs that include centre latitude, boundaries, widths, and additionally precipitation intensities using GPCP and TRMM datasets. The Northern Hemisphere (NH) ITCZs are found near 8° N, while the Southern Hemisphere (SH) ITCZs are near5° S. On the one hand, these results suggest that the NH ITCZs reach their northernmost centre latitude and the highest centre precipitation intensity in September and their southernmost in March; the full width peaks in August. On the other hand, the SH ITCZs start near the equator and migrate to reach the southernmost latitude in May. During their seasonal migration, the widths fluctuate with decreasing intensities. Generally, as found by previous studies, the NH ITCZs shift equatorward, narrow and intensify. The SH ITZCs shift poleward, narrow, and intensify under global warming.
Hypothalamic proteome analysis of insomnia rats treated by abdominal massage
Authors: Ye Zhang , de Yu Cong , Yufeng WANG , Peng LIU , Wu Siyuan , Zhi Xiaoyu , Lou Huijuan , Zhang Hongshi 
Published: June 2022

Abstract
Objective: To analyze differential protein expression in the hypothalamus of insomnia rats treated by abdominal massage using proteomic assays.Methods: The insomnia model was established by single intraperitoneal injection of p-chlorophenylalanine (PCPA) in rats. Then, the rats were divided into four groups, including the blank (B), insomnia model A (MA), insomnia model B (MB) and abdominal massage-treated insomnia (T) groups, with six rats in each group. Behavior experiments were carried out, and differential proteins in the hypothalamus of rats were identified and assessed for biological properties.Results: Based on weight, locomotor activity, righting reflex and Morris water maze (MWM) data, there were statistically significant differences after modeling, indicating the success of model establishment.Comparing the three groups of differential proteins, P97887 (presenilin-1) and A0A0G2JSP8 (creatine kinase) had elevated amounts after modeling and decreased levels after massage. Meanwhile, P19969 (gamma-aminobutyric acid receptor subunit alpha-5) and Q99P99 (histone deacetylase 4) were significantly decreased after modeling and significantly increased after massage treatment. Of the 4 tested proteins, 3 (presenilin-1, creatine kinase, and GABA alpha-5) showed trends consistent with mass spectrometry.Conclusion: Abdominal massage can treat insomnia by modulating P97887, A0A0G2JSP8, P19969, Q99P99 and other proteins are expressed during the treatment of insomnia.
Lost to Follow-Up and Its Predictors among Human Immune Deficiency Virus Infected Children on Antiretroviral Therapy, Southern Oromia, and Ethiopia: A Five Year Retrospective Cohort Study
Authors: Bankere Assefa Washo , Gemechu Bikila Lencha , Ami Bonso , Kebebe Lalisa , Gabisa Sintayehu 
Published: June 2022

Abstract
Background
Lost to follow-up among pediatric human immune deficiency virus infected patients is a major challenge for the global scale-up of lifesaving antiretroviral therapy (ART). It is considerable obstacle for effectiveness of the program which negatively impacted on immunological benefits of ART and drug adherence. Additionally, it increases drug toxicity, resistance and acquired immune deficiency syndrome related morbidity and mortality. Therefore, it is very crucial to identify the incidence and determinants of loss to follow up among children in study area.
Objectives
To determine incidence and determinants of lost to follow-up among human immune deficiency virus-infected children on Anti-Retroviral Treatment.
Method
A retrospective cohort study was conducted among 269 randomly selected children who had been on ART in the health facilities of Shashemene Town from January 1, 2015 to December 30, 2020. Data on patients’ medical records such as patient intake form and the registers were collected using standardized checklist. Data were coded and entered by Epidata version 3.1 and analyzed by Statistical Product and Service Solutions (SPSS) version 25. The Cox proportional hazard assumption was checked using Schoenfeld residual test (global test > 0.05). Finally, adjusted hazard ratio with 95% confidence interval was computed, and variables with P-values < 0.05 in multivariable analysis were taken as significant predictors of lost to follow up.
Results
Of 269 HIV-infected children included in the final analysis, 43 (16%) were loss to follow up. The overall incidence rate of loss to follow up was 3.3 with (95% CI: 2.4–4.4) per 100 Child-Year of observation. Age less than 5 years (AHR:0.03 95% CI: 0.003–0.361), non-orphan status of the child (AHR = 0.13(0.048–0.340), < 30-minute distance from health facility (AHR:0.24 95% CI:0.077–0.728), disclosed HIV status (AHR :0.32 95% CI :0.126–0.795), history of opportunistic infection (AHR: 3.54, 95%CI :1.152–10.866) and CD4 below threshold (AHR:5.17 95%:CI:2.082–12.8490) were significant determinants of loss to follow up.
Conclusion
The incidence density of loss to follow up in this study was low as compared to other studies. The finding indicated that older children, orphan, low immune status, undisclosed HIV status and distance from health facility were independent determinants of loss to follow up. Giving special attention to older, orphan and those with low CD4 count is mandatory. Age-appropriate disclosure should also be encouraged.
Continuing cyclin dependent kinase 4/6 inhibition with abemaciclib in metastatic breast cancer patients previously treated with palbociclib or ribociclib: a protocol for systematic review and meta-analysis
Authors: Aguilar Alicia de Luna , Fuentes Javier David Benitez , Arcilla Jorge Bartolome , Shah Richa , Avagyan Manushak , Frick Clara , Lorenzo Alfonso Lopez de Sa , Rojas Carmen Toledano , Anton Fernando Moreno , Saenz Jose Angel Garcia 
Published: June 2022

Abstract
Background
Breast cancer is the most frequent cancer in women worldwide. Most breast cancer cases are estrogen receptor positive and epidermal growth factor receptor 2 negative (ER+/HER2-). A small proportion of these cases are metastatic with Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors being the mainstay of treatment. Evidence supports the existence of differences between the three approved cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in both preclinical and clinical settings. Abemaciclib appears to be capable of inhibiting other targets. Senescence and apoptosis took place at an earlier time and with lower concentrations of abemaciclib compared to treatment with palbociclib or ribociclib in preclinical models.
Methods
A search will be performed on the PubMed, Embase, and Web of Science databases following Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. A manual search of the San Antonio Breast Cancer Conference, American Society of Clinical Oncology annual conference, European Society of Medical Oncology annual conference, and European Society of Medical Oncology Breast annual conference will be performed.
Discussion
To our knowledge, no previous systematic review has evaluated the available evidence regarding the efficacy and safety of abemaciclib in MBC previously treated with palbociclib or ribociclib. This systematic review and meta-analysis will synthesize the existing data on the effectiveness and safety of abemaciclib after prior exposure to ribociclib or palbociclib in MBC. It will also identify the gap in the literature for potential future research. The results of this study will be of interest to multiple audiences including patients, their families, caregivers, and healthcare professionals. Results will be published in a peer-reviewed journal.
Systematic review registration:
PROSPERO CRD42022330355
Remdesivir resistance in transplant recipients with persistent COVID-19
Authors: Hogan John I , Duerr  , Dimartino Dacia , Marier Christian , Hochman Sarah , Mehta Sapna , Wang Guiqing , Heguy Adriana 
Published: June 2022

Abstract
The medical community currently lacks robust data regarding the incidence, prevalence, and clinical significance of mutations associated with resistance to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) therapeutics. This report describes two renal transplant recipients who, after remdesivir exposure, developed a de novo V792I RNA-dependent RNA polymerase (RdRp) mutation that has recently been found to confer resistance to remdesivir in vitro. To the best of our knowledge, this publication is the first to document the emergence of V792I in patients treated with remdesivir. Our work underscores the critical need for augmented efforts to identify concerning mutations and address their clinical implications.
SUMBER BELAJAR ALTERNATIF MATA KULIAH AKUNTANSI BAGI MAHASISWA GENERASI Z
Authors: Sari Padma Adriana , Fazda Oktavia Fathimatus Zahro 
Published: June 2022

Penyesuaian dan inovasi pada proses pembelajaran diperlukan untuk memenuhi kebutuhan mahasiswa generasi Z terutama di era pembelajaran online seperti saat ini sehingga tercapai proses pembelajaran yang efektif. Tujuan penelitian ini adalah untuk mengetahui sumber belajar yang diminati oleh mahasiswa generasi Z serta alternatif sumber belajar yang telah digunakan oleh dosen pengajar akuntansi. Teknik survei digunakan dalam penelitian ini untuk mengumpulkan data. Kuesioner dibagikan secara online kepada mahasiswa akuntansi serta dosen akuntansi di beberapa universitas dan politeknik di Indonesia. Data yang dikumpulkan dianalisis dengan metode deskriptif. Hasil penelitian menyebutkan bahwa sumber belajar yang digunakan dosen akuntansi telah sesuai dengan kebutuhan mahasiswa generasi Z, yaitu menggunakan video pembelajaran, modul serta perpaduan berbagai sumber belajar lain dalam mata kuliah akuntansi. Video pembelajaran yang diinginkan responden mahasiswa adalah yang menarik, disertai animasi, contoh kasus di lapangan serta contoh soal dan pembahasannya. Hasil penelitian ini diharapkan untuk dijadikan referensi oleh dosen akuntansi yang sedang mencari alternatif sumber belajar untuk mengajarkan mata kuliah akuntansi di kelas, terutama dalam menghadapi generasi Z yang membutuhkan kondisi belajar yang menarik dan menyenangkan pada proses pembelajaran online di era pandemi seperti saat ini.
CARDIO- AND NEUROPROTECTION IN AUTONOMOUS HEART NEUROPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS (literature review and own data)
Authors: Sergienko V. O. 
Published: June 2022

There are two main forms of damage myocardium in diabetes mellitus: diabetychna kardiomiopatiya (Non-Coronary genesis i (ishemic). Vydilyayut, metabolic or metabolic-hipoksychnu stage, which is of specific metabolic disease MC belonging to the secondary metabolic endocrine kardiopatiy, metabolic-ishemichnu stage, infarkt miokarda, dystrophic koronarosklerotychnyy kardioskleroz; diabetychnu autonomous nevropatiyu heart DANS is one of the most serious complications of diabetes, which is diagnosed poorly,
may be accompanied by severe postural hypotension, impaired exercise tolerance, be the cause of coronary ischemia, "dumb" MI,
syndrome of "sudden" death.