bluuebunny/crossref_metadata_2025_split huggingface dataset:
Los costos laborales y su influencia en la informalidad de contratación de personal en las MYPEs de la ciudad de Moyobamba, Perú 2021
Authors: Pérez Arteaga Lidia , Regalado Rodríguez Sonia Janeth 
Published: May 2022

La presente investigación ha tenido como objetivo principal determinar si los costos laborales influyen en la contratación informal de personal en las MYPEs de la ciudad de Moyobamba 2021, la metodología fue de tipo aplicada, no experimental de nivel descriptivo correlacional, con una población de 354 gerentes de micro y pequeños empresarios, se llegó a la siguiente conclusión: Los costos laborales influyen altamente en la contratación informal de personal en las MYPEs de la ciudad de Moyobamba 2021, en forma parcial según el resultado inferencial indica el ρ-valor “Sig. Bilateral” ρ = 0.001 (ρ<0.05), lo que demuestra y por loque se acepta la H1, evidenciando que existe un nivel positivo de significancia entre las variables Costos laborales y Contratación de personal. De acuerdo al coeficiente de correlación es igual a 0.769 (r=0.769), estando este en un valor en el rango de correlación muy buena, con una orientación positiva entre las variables en estudio, de igual manera el análisis descriptivo si considera que los costos laborales son altos para la contratación de personal, existe un 60% dice nunca y casi nunca, un 5% neutro, y 35% indica casi siempre y siempre, de lo que se evidencia que para una mayoría 60% los costos laborales no son altos, pero si para un 35% que lo si considera que son altos, lo cual evidencia porque este porcentaje no contrata al personal formalmente.
Hematoloji ve Onkoloji Hemşirelerinde Merhamet Düzeyi ve İlişkili Faktörler
Authors: ESKİMEZ Zehra , KÖSE TOSUNÖZ İpek , ŞİŞMAN Hamide , AKYÜZ Sibel 
Published: May 2022

Amaç: Araştırmanın amacı, bir üniversite hastanesinde çalışan hematoloji ve onkoloji hemşirelerinin merhamet düzeyini ve ilişkili faktörleri belirlemektedir.
Yöntem: Tanımlayıcı ve kesitsel nitelikteki araştırmanın evrenini bir üniversite hastanesinin çocuk ve yetişkin hematoloji ve onkoloji klinikleri ile kemik iliği transplantasyon ünitesinde çalışan hemşireler oluşturmuştur. Örneklem seçimine gidilmemiş ve araştırmaya katılmayı kabul eden tüm hemşireler (n=65) araştırma kapsamına alınmıştır (Katılım oranı %100). Veri toplama aracı olarak, "Tanıtıcı Bilgi Formu" ve "Merhamet Ölçeği" kullanılmıştır. Verilerin analizleri bir istatistik paket programında tanımlayıcı istatistikler ile Independent t Test, Varyans Analizi, Mann-Whitney U Testi ve Kruskal-Wallis H Testi kullanılarak yapılmıştır.
Bulgular: Hemşirelerin Merhamet Ölçeği toplam puan ortalamaları 4.04±0.51; alt boyut puan ortalamaları ise sevecenlik 4.03±0.72; paylaşımların bilincinde olma 4.10±0.70; bilinçli farkındalık 4.10±0.70; umursamazlık 4.16±0.62, bağlantısızlık 3.91±0.64 ve ilişki kesme için 4.03±0.66 olarak belirlenmiştir. Hemşirelerin sevecenlik alt boyut puan ortalamaları ile yaşları, cinsiyetleri ve eğitim düzeyleri arasında; paylaşımların bilincinde olma alt boyut puan ortalamaları ile eğitim düzeyleri, çalıştıkları birim ve çalıştıkları birimdeki hizmet süreleri arasında; bilinçli farkındalık ve ilişki kesme alt boyut puan ortalamaları ile cinsiyetleri arasında istatistiksel olarak anlamlı bir ilişki olduğu saptanmıştır (p
An academic–industrial collaboration delivering better starting points for drug discovery: new compound libraries driven by intelligent design
Authors: Cox Liam 
Published: May 2022

An academic–industrial collaboration delivering better starting points for drug discovery: new compound libraries driven by intelligent design
Project iDesign’s primary research objective is to deliver better starting points for early-stage drug discovery. To this end, we have synthesised compound libraries comprising molecules that are demonstrably novel, structurally and functionally diverse, and lead-like in character. Designed with safety considerations from the outset, our libraries interrogate underexplored regions of chemical space and therefore complement existing diversity sets.
Averroè, una traduzione ininterrotta
Authors: Illuminati Augusto 
Published: May 2022

La mia collaborazione con Massimo Campanini si è sviluppata su comuni interessi per i classici del pensiero islamico ma con competenze assai diverse, essendo io più orientato a studiare gli effetti e gli sviluppi che essi produssero sul pensiero occidentale medievale e moderno attraverso una pratica di traduzioni spesso creative per imprecisione – l’inverso dell’operazione che essi stessi avevano fatto rispetto a Platone e Aristotele.Averroè-Ibn Rushd è già un bell’esempio di deformazione del nome, ma proprio la formazione della sua opera e i modi in cui è stata trasmessa al mondo ebraico e cristiano sono singolari testimonianze degli esiti ambigui del processo traduttivo. Cerchiamo infatti di mostrare come la lettura del De substantia orbis abbia stimolato sia nel Medioevo che nel Rinascimento non solo il rifiuto del creazionismo ma anche posizioni panteistiche, mentre la famosa tesi dell’intelletto materiale unico contenuta nel Commentarium Magnum al De anima aristotelico ha stimolato molteplici varianti del monopsichismo, da Spinoza a Marx e alla più recente letteratura post-strutturalista.
My collaboration with Massimo Campanini developed around our common interests in the classics of Islamic thought, but with very different approaches, since I am more oriented towards studying the effects and developments they produced on medieval and modern Western thought through a practice of translation that was often creative in terms of inaccuracy – so the opposite of what had been done with respect to Plato and Aristotle.The same Averroes-Ibn Rushd is a fine example of name distortion, and the very formation of his work and the ways in which it was transmitted to the Jewish and Christian world are singular testimonies to the ambiguous outcomes of this translation process. I try to show how the reading of De substantia orbis in the Middle Ages and the Renaissance stimulated not only the rejection of creationism but also pantheistic beliefs, while the famous thesis on the material intellect exposed in the Commentarium Magnum to Aristotle’s De anima stimulated many variants of monopsychism, from Spinoza to Marx and the more recent post-structuralist literature.
Monsoon rainfall variability and rainfed agriculture in the water-scarce Karha Basin, western India
Authors: TODMAL RAHUL S. , KALE VISHWAS S. 
Published: May 2022

Recent climate projection models indicate that the semi-arid regions of the world are most vulnerable to the impact of climate change. Hence, the understanding of rainfall variability and availability of water resources in water-scarce regions is crucial for planners to formulate annual plan for judicious utilization and distribution of water. In the present study, an attempt is made to evaluate the hydro-meteorological characteristics of the Karha Basin, located in the rain shadow zone of the Western Ghat. Trends in monsoon rainfall, dam storage and the area under some principal crops were analyzed to ascertain their interrelationship. The analyses indicate high inter-annual variability in monsoon rainfall and distinct episodes of above - and below-average monsoon rainfall. There is enough evidence for enhanced monsoon variability during the recent decades and a tendency for weaker monsoons to be associated with El Niño events. The study also provides evidence of changes in the area under major crops with the multi-year fluctuations in monsoon rainfall and dam water storage. The relationship, however, is not as strong as expected and the pattern gets more erratic and confusing in the most recent decades, partly on account of increasing dependence on irrigation. The Karha Basin is already suffering from severe water scarcity. Increasing monsoon variability, seasonality and dependence on groundwater is likely to threaten agriculture and food security. Climate change related impacts are likely to further add to already difficult water management challenges in the basin. It is therefore necessary to plan for new challenges under climate change scenarios.
Đặc điểm lâm sàng và thực trạng chẩn đoán ung thư thanh quản tại một số bệnh viện ở Hà Nội hiện nay
Authors: Lê Thị Hòa 
Published: May 2022

Mục tiêu: Mô tả đặc điểm lâm sàng và thực trạng chẩn đoán ung thư thanh quản tại một số bệnh viện ở Hà Nội.
Đối tượng và phương pháp nghiên cứu: Hồi cứu mô tả trên 828 người bệnh được chẩn đoán xác định bằng lâm sàng và giải phẫu bệnh là ung thư thanh quản được điều trị tại Bệnh viện Tai mũi họng trung ương, Bệnh viện K trung ương, Bệnh viện Ung bướu Hà Nội từ 2014 đến 2019.
Kết quả: Triệu chứng cơ năng thường thấy nhất là khàn tiếng chiếm 96,1% ; người bệnh được phát hiện bệnh dưới 6 tháng kể từ khi có triệu chứng cơ năng đầu tiên là 84,7%; ung thư khởi đầu từ thanh môn chiếm tỷ lệ cao nhất 94,3%; Tổn thương ung thư khu trú ở 1 tầng thanh quản chiếm 53%, chủ yếu ở thanh môn (49,6%); người bệnh được chẩn đoán ở giai đoạn sớm T1, T2 với tỷ lệ 87,2%; Số người bệnh không có di căn hạch vùng chiếm tỷ lệ cao nhất 98,1%.
Kết luận: Triệu chứng lâm sàng chủ yếu trên người bệnh ung thư thanh quản là khàn tiếng. Đa số người bệnh được chẩn đoán bệnh ở giai đoạn sớm và tỷ lệ di căn hạch thấp.
Research on the Renewal Strategy of Daiwei Historical Village from the Perspective of Shrinkage
Authors: Tan Yue 
Published: May 2022

With the transformation of urban construction and the implementation of the rural revitalization strategy, it makes the renewal and development of historical villages face "shrinking crisis" and "regeneration opportunity". After summing up the research on shrinkage, this paper puts forward that the renewal of historical villages should hold four shrinking perspectives including agricultural ecology, effective population, historical culture and educational inheritance. Through studying and analyzing the three levels of the social environment, artificial environment and natural environment, three strategies of renewal for agriculture, rural areas and farmers are put forward by taking Daiwei village as an example. These strategies are "adhere to agricultural production, promote industrial innovation", "adhere to rural urbanization, improve the living environment" and "adhere to farmer's education, inherit history and culture".
Feasibility Study of Na-Oogst Tobacco in Jember District
Authors: Muhammad Firdaus  , Nanda Widaninggar  , Farid Wahyudi  , Ahmad Sauqi  , Suherman  
Published: May 2022

Na-Oogst tobacco or also called Besuki Na-Oogst tobacco is a type of cigar tobacco that is grown in the dry season and harvested at the beginning of the rainy season where the export market share is very promising at a high enough price. Jember is the center of this type of tobacco. This study aims to determine the level of profit and feasibility of Tobacco Na Oogst farm business in Jember Regency. This study used Multistage Cluster Sampling, with the number of respondents are 120 people. The results showed that Tobacco Na Oogst farm business per hectare requires a total cost of Rp27,042,469 and resulted in a total revenue of Rp168,633,671. Thus, Tobacco Na Oogst farm business per hectare is able to produce a net profit of Rp141,591,202. The R/C Ratio of Tobacco Na Oogst farm business is 6.24 (R/C ratio> 1). This means that every Rp1,000 the costs incurred for Tobacco Na Oogst farm business able to provide revenue of Rp6,240. Therefore, Tobacco Na Oogst farm business is feasible.
Seven Sublimes
Authors: Nye David E. 
Published: May 2022

A reconception of the sublime to include experiences of disaster, war, outer space, virtual reality, and the Anthropocene.
We experience the sublime—overwhelming amazement and exhilaration—in at least seven different forms. Gazing from the top of a mountain at a majestic vista is not the same thing as looking at a city from the observation deck of a skyscraper; looking at images constructed from Hubble Space Telescope data is not the same as living through a powerful earthquake. The varieties of sublime experience have increased during the last two centuries, and we need an expanded terminology to distinguish between them. In this book, David Nye delineates seven forms of the sublime: natural, technological, disastrous, martial, intangible, digital, and environmental, which express seven different relationships to space, time, and identity.
These forms of the sublime can be experienced at historic sites, ruins, cities, and national parks, or on the computer screen. We find them in beautiful landscapes and gigantic dams, in battle and on battlefields, in images of black holes and microscopic particles. The older forms are tangible, when we are physically present and our senses are fully engaged; increasingly, others are intangible, mediated through technology. Nye examines each of the seven sublimes, framed by philosophy but focused on historical examples.
Transcriptome changes in ERGIC3-knockdown hepatocellular carcinoma cells: ERGIC3 is a novel immune function related gene
Authors: Liu Mengyuan , Zhao Qiurong , Zheng Xiang , Yang Lei , Zhao Yanyu , Li Xueying , Wu Mingsong 
Published: May 2022

Objective
The expression of ERGIC3 is increased in a variety of tumors and promotes the growth and metastasis of liver cancer, but the molecular mechanism needs to be further studied.In this study, we aimed to analyze the molecular mechanism of ERGIC3 regulating the proliferation of human hepatocellular carcinoma (HCC) SMMC-7721 cells using transcriptomics.

Methods
ERGIC3 was knocked down in SMMC-7721 cells by RNAi technique, and the expression of ERGIC3 was detected by Q-RT-PCR and Western Blot. RNA sequencing was performed in the Illumina HiSeq platform in the control group and the ERGIC3i group and bioinformatics methods were selected to analyze the data.

Results
The expression of ERGIC3 was reduced to 10% in SMMC-7721 cells by RNAi technique, and 176 genes were up-regulated and 34 genes were down-regulated in ERGIC3i group compared with the control group. Analysis of the pathways and biological processes that enrich the function of differentially expressed genes showed thatthese differentially expressed genes were mainly involved in vesicular transport, growth factors, PI3K-Akt, NOD-like, Jak-STAT, NF-kappa B and other protein kinase-coupled receptors mediated signal transduction pathways, tumor immune response, collagen-integrin receptor-actin axis, and miRNA pathways. More importantly, most of the significantly altered pathways were related to immunity. ERGIC3 may be a key immune-related gene.

Conclusion
Based on the transcriptomic analysis, the mechanism of ERGIC3 promoting the growth of HCC is link with the transport of growth factor receptor, cytokine receptor and collagen. Then it is involved in signal transduction pathways mediated by protein kinase-coupled receptors, PI3K-Akt, NOD-like, Jak-STAT and NF-kappa B. In particular, the mechanism is also involved in the ERGIC3-dependent immune pathways. ERGIC3 is a potential target for prevention and treatment of HCC.
Retrobulbar Amphotericin B in Mucormycosis: A Ray of Hope
Authors: Mohan Shalini , Sahai Kunal , Patel Namrata , Chandra Tejasvini , Kumar Priyesh 
Published: May 2022

Aim:
The aim of the study was to study the role of Retrobulbar Amphotericin B in patients with Mucormycosis.

Methods:
The retrospective study conducted on 86 cases at a tertiary care hospital analyzed detailed history, examination and management options. The staging was done on basis of clinical and radiological examination. Management included functional endoscopic sinus debridement followed by lavage with Liposomal Amphotericin B. The patients with ocular involvement were subjected to Exenteration or Retrobulbar injections of Amphotericin B (3.5 mg / ml) based on the disease staging.

Results:
Most common risk factors were steroid intake (89.5 %) and Diabetes (87.2%). Seventy four eyes of 71 patients had ocular involvement out of which 20 eyes (27.0%) of 19 patients (26.7%) presented with no perception of light. Seven patients were subject to exenteration of globe and 58 eyes were given Retrobulbar injections (Mean number of injections = 5.58 ± 2.36). The mean best corrected visual acuity of 0.769± 0.935 logMar did not deteriorate (p=0.871) post treatment. The mean restriction of extraocular movements were 2.32± 1.09 which improved to 1.56 ± 1.56 (p=0.0031) following retrobulbar injections.

Conclusion:
The patients of Mucormycosis without cerebral involvement can be subjected to Retrobulbar Amphotericin B injections that can control the ocular manifestations and stabilise the vision thus saving the globe..
A new analytical model for the response curve in megavoltage photon beams of the radiochromic EBT3 films measured with flatbed scanners
Authors: Rodríguez César , García‐Pinto Diego , Martínez Luis Carlos , López‐Fernández Alfonso 
Published: May 2022

AbstractPurposeThe aim of this work is to study a new analytical model which describes the dose–response curve in megavoltage photon beams of the radiochromic EBT3 film measured with two commercially available flatbed scanners. This model takes into account the different increase of the number of two types of absorbents in the film with absorbed dose and it allows to identify parameters that depend on the flatbed scanner and the film model, and parameters that exclusively depend on the production lot. In addition, the new model is also compared with other models commonly used in the literature in terms of its performance in reducing systematic calibration uncertainties.Methods and materialsThe new analytical model consists on a linear combination of two saturating exponential functions for every color channel. The exponents modeling the growing of each kind of absorbent are film model and scanner model‐dependent, but they do not depend on the manufacturing lot. The proposed model considers the different dose kinetics of each absorbent and the apparent effective behavior of one of the absorbents in the red color channel of the scanner.The dose–response curve has been measured using EBT3 films, a percentage depth dose (PDD) calibration method in a dose range between 0.5 and 25 Gy, and two flatbed scanners: a Microtek 1000 XL and an EPSON 11000 XL. The PDD calibration method allows to obtain a dense collection of calibration points which have been fitted to the proposed response curve model and to other published models. The fit residuals were used to evaluate the performance of each model compared with the new analytical model.ResultsThe model presented here does not introduce any systematic deviations up to the degree of accuracy reached in this work. The residual distribution is normally shaped and with lower variance than the distributions of the other published models. The model separates the parameters reflecting specific characteristics of the dosimetry system from the linear parameters which depend only on the production lot and are related to the relative abundance of each type of absorbent. The calibration uncertainty is reduced by a mean factor of two by using this model compared with the other studied models.ConclusionsThe proposed model reduces the calibration uncertainty related to systematic deviations introduced by the response curve. In addition, it separates parameters depending on the flatbed scanner and the film model from those depending on the production lot exclusively and therefore provides a better characterization of the dosimetry system and increases its reliability.
Strong and Tough Conductive Organo‐Hydrogels via Freeze‐Casting Assisted Solution Substitution
Authors: Dong Xinyu , Guo Xiao , Liu Quyang , Zhao Yijing , Qi Haobo , Zhai Wei 
Published: May 2022

AbstractHigh strength, toughness, and conductivity are among the most sought‐after properties of flexible electronics. However, existing engineering materials find it difficult to achieve both excellent mechanical properties and high conductivity. To address this challenge, this study proposes a facile yet versatile strategy for preparing super‐tough conductive organo‐hydrogels via freeze‐casting assisted solution substitution (FASS). This FASS strategy enables the formation of organo‐hydrogels in one step with exquisite hierarchical anisotropic structures coupled with synergistic strengthening and toughening effects across multiple length scales. As an exemplary material, the prepared polyvinyl alcohol (PVA) organo‐hydrogel with solvent content up to 87 wt% exhibits a combination of high strength (6.5 MPa), high stretchability (1710% in strain), ultra‐high toughness (58.9 MJ m−3), as well as high ionic conductivity up to 6.5 S m−1 with excellent strain sensitivity. The exceptional combination of mechanical properties and conductivity makes the PVA organo‐hydrogel a promising flexible electronics material. In addition, the FASS strategy can also endow hydrogels with multi‐functions, including thermo‐healability, freezing tolerance and shape recoverability, and can be applied to various hydrogel materials, such as carboxymethyl cellulose, sodium alginate, and chitosan. Hence, this work provides an all‐around solution for preparing advanced strong and tough conductive soft materials for a multitude of applications.
Long‐Acting Protective Ocular Surface by Instilling Adhesive Dual‐Antiviral Nanoparticles
Authors: Wang Xinyue , Chen Liangbo , Wang Xinling , Zhang Mengmeng , Yang Fengmin , Wu Feng , Liu Jinyao , Lu Lu , Pang Yan 
Published: May 2022

AbstractThe eye is susceptible to viral infections, causing severe ocular symptoms or even respiratory diseases. Methods capable of protecting the eye from external viral invasion in a long‐term and highly effective way are urgently needed but have been proved to be extremely challenging. Here, a strategy of forming a long‐acting protective ocular surface is described by instilling adhesive dual‐antiviral nanoparticles. Taking pseudotyped severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) as a model virus, antiviral agent‐loaded nanoparticles are coated with a “double‐lock” hybrid cell membrane abundant with integrin‐β1 and angiotensin converting enzyme II (ACE2). After instillation, the presence of integrin‐β1 endows coated nanoparticles with steady adhesion via specific binding to Arg‐Gly‐Asp sequence on the fibronectin of ocular epithelium, achieving durable retention on the ocular surface. In addition to loaded inhibitors, the exposure of ACE2 can trap SARS‐CoV‐2 and subsequently neutralize the associated spike protein, playing a dual antiviral effect of the resulting nanoparticles. Adhesive dual‐antiviral nanoparticles enabled by coating with a “double‐lock” hybrid cell membrane could be a versatile platform for topical long‐acting protection against viral infection of the eye.