bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning-based methods for forecasting Brent Crude Oil return considering COVID-19 pandemic effect
Authors: Khodaee Pouya , Sajadi Seyed Mehrzad Asaadi , Hajizadeh Ehsan , Farhadi Sabri 
Published: February 2022

Abstract
Forecasting return and profit is a primary concern for financial practitioners. It is even more critical when it comes to forecasting energy market returns. This research attempts to propose an effective method for predicting the Brent Crude Oil return, which results in remarkable performance compared to the well-known models in the return prediction. The proposed model is a hybrid model based on LSTM and CNN networks where ARIMA and GARCH outputs are used as features along with return lags, price, and macroeconomic variables for training the models, resulting in significant improvement in the model's performance. According to the obtained results, our proposed model performs better than other models, including ANN, PCA-ANN, LSTM, CNN. In the second part of this study, by considering the spread of the COVID-19 and its impact on the financial markets, we present a precise LSTM model that can reflect this disease's impact on the Brent Crude Oil return. This paper uses the significance test and correlation measures to show similarity between the series of Brent Crude Oil during the SARS period and COVID-19; after that, we use SARS period data along the COVID-19 to train the LSTM. The results demonstrate that the proposed LSTM model, tuned by the SARS data, can better predict the Brent Crude Oil return during the COVID19 pandemic.
Investigating the Effectiveness of Tele-Counselling Psychological Intervention on the Perinatal Mental Health During the Outbreak of COVID-19: A Randomized Trial
Authors: Dadshahi Sahebeh , Ahmadi Atefeh , Ghazanfarpour Masumeh , Alidousti Katayoun , Yousefi Setareh , Pakdel Zahra , Nasrollahi Masoumeh , kashfi Zahra , Esmaeilinejadhasaroeih Fatemeh , Khaleghi Rezvan , Noormohammadi Parinaz 
Published: February 2022

Abstract
Design: This is a randomized trial with a control and an intervention group. The aim of this study was to investigate the effect of psychological interventions on women's mental health in the perinatal period duringsars-cov-2 pandemic. Method: This study was performed on 60 women in the perinatal period (30 in the control group and 30 in the intervention group). The women in the intervention group were included in 6 weekly sessions of 90-120 minutes of tele-counseling. Anxiety, depression, health anxiety and its dimensions were assessed by modified Hospital Anxiety-Depression Scale (HADS) and Short Health Anxiety Index (SHAI) before and after the intervention in both groups. Data were analyzed by SPSS-22 and Kolmogorov-Smirnov, Shapiro-Wilkes tests, one way-ANOVA and paired t-test, Kruskal-Wallis, Wilcoxon paired t-test and K-2. Results: Health anxiety had a significant decrease in both dimensions (anxiety of being sick and negative consequences of disease) (p = 0.007, p = 0.005) while depression and anxiety related to COVID-19 hadn’t been changed significantly (P = 0.34 and p = 0.92). Conclusion: Psychological intervention by tele-counseling approach can be effective as a suitable therapeutic approach to reduce health anxiety in the perinatal period. Trial registration: IRCT20170611034452N12. Trial Id: 50289, 12/20/2020 Keywords: Psychological interventions, tele-counseling, mental health, Corona, perinatal period
Analysis Of The Genotypic Profile And Its Relationship With The Clinical Manifestations In People With Cystic Fibrosis: Study From A Registry Of Rare Diseases.
Authors: Nieto Senay Rueda , Mondejar-Lopez Pedro , Mira-Escolano María-Pilar , Cutillas-Tolín Ana , Maceda-Roldán Luis Alberto , Arense-Gonzalo Julián Jesús , Palomar-Rodríguez Joaquín A. 
Published: February 2022

Abstract
Background: Cystic fibrosis (CF) has a very heterogeneous mutational spectrum in Europe. This variability has also been described in Spain, and there are numerous studies that relate CFTR variants with the symptoms of the disease. Most of them analyze determinate clinical manifestations or specific sequence variants in patients from clinical units. Others use registry data without addressing the genotype-phenotype relationship. Therefore, the objective of this study is to describe the genetic and clinical characteristics of people with CF, and to analyze the relationship between both, using data from the rare diseases registry of a region in southeastern Spain.Methods: A cross-sectional study was carried out in people with a confirmed diagnosis of CF registered in the Rare Diseases Information System (SIER) of the Region of Murcia (Spain). The patients were classified into two genotypes according to the functional consequence that the genetic variants had on the CFTR protein.Results: There were 192 people diagnosed with CF reported in the Region of Murcia until December 31, 2018. Seventy-six different variants were described being the most common c.1521_1523delCTT (p.Phe508del) in 58.3% of people and 37.0% of alleles. Sixty-seven percent of the patients were classified as high-risk genotype, which was associated with a lower percentage of FEV1 [OR: 3.4 (95%CI: 1.1, 10.8)], an increased risk of colonization by Pseudomonas aeruginosa and Achromobacter xylosoxidans [OR: 4.2 (95%CI: 1.3, 13.8) and 7.1 (95%CI: 1.1, 47.2), respectively] and the presence of pancreatic insufficiency [OR: 21.8 (95%CI: 7.9, 59.9)] as compared with those with mild variants.Conclusions: The Region of Murcia has one of the lowest allele frequencies of p.Phe508del described in Europe and high genetic heterogeneity, which could explain the high proportion of patients with mild disease. Furthermore, our results support the association between genotypes compound of two severe variants and the presence of pancreatic insufficiency, increased risk of respiratory infection, and serious lung damage.
Dexmedetomidine Alleviates Inflammatory Response and Oxidative Stress Injury of Vascular Smooth Muscle Cell via α2AR/PI3K/AKT Pathway in Intracranial Aneurysm
Authors: Zhang Ze , Mu Xiue , Zhou Xiaohui 
Published: February 2022

Abstract
Vascular smooth muscle cell (VSMC) phenotypic modulation regulates the initiation and progression of intracranial aneurysm (IA). Dexmedetomidine (DEX) is reported to play neuroprotective roles in patients with craniocerebral injury. Therefore, we investigate the biological functions of DEX and its mechanisms against IA formation and progression. Rat primary VSMCs were isolated from Sprague-Dawley rats. IA and STA tissue samples were obtained from patients with IA. Hydrogen peroxide (H2O2) was used to mimic IA-like conditions in vitro. Cell viability was detected using CCK-8 assays. Wound healing and Transwell assays were performed to detect cell motility. ROS production was determined by flow cytometry. Western blotting and RT-qPCR were carried out to measure gene expression levels. Inflammation responses were determined by measuring inflammatory cytokines. Immunohistochemistry staining was conducted to measure α2-adrenergic receptor levels in tissue samples. DEX alleviates the H2O2-induced cytotoxicity, attenuates the promoting effects of H2O2 on cell malignancy, and protects VSMCs against H2O2-induced oxidative damage and inflammation response. DEX activates the GSK-3β/MKP-1/NRF2 pathway via the α2AR. DEX alleviates the inflammatory responses and oxidative damage of VSMCs by activating the GSK-3β/MKP-1/NRF2 pathway via the α2AR in IA.
The correlation of the serum kynurenine level with P50 in first-episode patients with schizophrenia
Authors: Tan Yunlong , Yang Qingyan , Zhang Yong , Yang Kebing , Niu Yajuan , Fan Fengmei , Chen Song , Luo Xingguang , Tan Shuping , Wang Zhiren , Tong Jinghui , Yang Fude , Li Chiang-Shan R. 
Published: February 2022

Abstract
Background: Increasing facts demonstrated the occurrence of sensory gating defects in schizophrenic sufferers, which had relation to the weakening of P50 response inhibition and had association with α7 nicotinic acetylcholine receptor (α7nAChR). Nevertheless, as a noncompetitive antagonist of α7nAChR, Kynurenic acid (KYNA) cannot cross the blood-brain barrier (BBB). In contrast, Kynurenine (KYN), as a precursor of KYNA metabolism, is capable of crossing the BBB. The exploration focused on investigatating the relation of the serum KYN level with P50 among first-episode patients with schizophrenia (FEPS).Methods: In the exploration, measurement of P50 sensory gating was conducted among 82 FEPS and 73 healthy controls (HC). Positive and Negative Syndrome Scale (PANSS) was used for assessing the psychopathology; and liquid chromatography-tandem mass spectrometry was utilized for measuring the the serum KYN level. Spearman rank correlation coefficient was used to test the correlation between P50 index and serum KYN level and PANSS score. Pearson correlation coefficient was used to test the correlation between serum KYN level and PANSS score.Results: The serum KYN levels[(251.46 ± 65.93) ng/ml vs. (320.65 ± 65.89) ng/ml, t = -6.38, p < 0.001], S1 amplitude [ (2.88(1.79, 3.78) μV vs. 3.08(2.46, 4.56) μV , Z = -2.17, p =0.030] and S1 minus S2 amplitude [1.60(0.63, 2.49) μV vs. 1.92(1.12, 2.93) μV , Z = -2.23, p = 0.026] in FEPS were apparently lower than those in the HC. An obviously inverse correlation was seen between S1 minus S2 amplitude and the serum KYN levels (r = -0.32, p = 0.004) in the FEPS.
Biochemical composition, nutraceutical profile, and GC-MS analysis of novel euryhaline microalgal cultures from Punjab, India.
Authors: Garg Diksha , Gupta Urmila 
Published: February 2022

Abstract
Microalgae have gained recognition in the scientific community as a potential source of nutraceuticals because it is a sustainable reservoir having the capability to substitute the industrial production of ordinary organic chemical based health supplements. The biomass of microalgae incorporates various functional biomolecules like chlorophyll, carotenoids and phenols that exhibit therapeutic properties and serve as nutraceuticals. In spite of the higher production of the microalgal biomass, their biochemical composition differs, and lack of characterization for nutraceutical properties are the prime hindrance in upscaling these bio-factories. Nutraceuticals are nutrient components of the food that not only exhibit many health benefits but also prevent the occurrence of various health disorders. Two euryhaline microalgal strains BGLR8 and BGLR16, isolated from water logged areas of Punjab, India were screened for biomass production and biochemically characterized for the nutraceutical values. Results indicated that BGLR8 produced maximum amount of nutraceutical compounds such as lipid (86 mg/g), chlorophyll (29.42 mg/g), carotenoid (28.82 mg/g), phenols (4.46 mg/g), phycocyanin (52 mg/g), astaxanthin (19.27 mg/g) and β-carotene (5.6 mg/g) and anti-oxidant activity (31.73%). The results of Gas Chromatography-Mass Spectrometry (GC-MS) revealed the presence of 8 therapeutic compounds viz. Dimethyl (E)-but-2-enedioate, Hexasilacyclododecane, Heptasilacyclotetradecane, Methyl (Z)-pentadec-8-enoate, Methyl octadec-13-enoate, Methyl hexadecanoate, Methyl octadecanoate, Methyl-octadeca-9,12-dienoate in BGLR8. Molecular identification through 18S rRNA gene sequencing confirmed BGLR8 to be a member of Coelastrella. (GenBank accession no.- MW443083.1).
Efficient Biodegradation of Di-(2-Ethylhexyl) Phthalate by a Novel Strain Nocardia Asteroides LMB-7 Isolated From Electronic Waste Soil
Authors: Chang Tian-Tian , Lin Zhi-Wei , Zhang Liu-Qing , Liu Wei-Bing , Zhou Ying , Ye Bang-Ce 
Published: February 2022

Abstract
The di-2-ethylhexyl phthalate (DEHP) degrading strain LMB-7 was isolated from electronic waste soil. According to its biophysical/biochemical characteristics and 16S rRNA gene analysis, the strain was identified as Nocardia asteroides. Optimal pH and temperature for DEHP degradation were 8.0 and 30°C, respectively, and DEHP removal reached 97.11% after cultivation for 24 h at an initial concentration of 400 mg/L. As degradation intermediates, di-butyl phthalates, mono-2-ethylhexyl phthalate and 2-ethylhexanol could be identified, and it could be confirmed that DEHP was completely mineralized by strain LMB-7. To our knowledge, this is the first report of DEHP degradation by a strain of Nocardia asteroides, at rates higher than those reported to date. This finding provides a new way for DEHP elimination from environment.
Cellulomonas Triticagri Sp. Nov., A Novel Actinomycete Isolated From The Rhizosphere Soil Of Wheat (Triticum Aestivum L.)
Authors: Han Chuanyu , Zhang Yuting , Yu Bing , Shan Qiqi , Zhao Junwei , Shi Haoran , Tian Yuanyuan , Zhang Yan , Zhu Chunyu , Xiang Wensheng 
Published: February 2022

Abstract
A Gram-positive, motile, rod-shaped and lignin-degraded novel actinomycete, designated strain NEAU-YY56T, was isolated from the rhizosphere soil of wheat (Triticum aestivum L.) collected from Zhumadian, Henan Province, Central China and characterized using a polyphasic approach. Phylogenetic analysis based on the 16S rRNA gene sequence indicated that strain NEAU-YY56T belonged to the genus Cellulomonas and exhibited 16S rRNA gene sequence similarities of 98.7, 98.2 and 98.1 % to Cellulomonas pakistanensis JCM 18755T, Cellulomonas denverensis W6929T and Cellulomonas hominis JCM 12133T, respectively. The morphological characteristics [Gram-positive and short rod-shaped cells] and chemotaxonomic properties [whole-cell sugars: glucose, rhamnose and ribose; major polar lipids: diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol mannoside and two unknown glycolipids; major menaquinones: MK-9(H4) and MK-9(H2); major fatty acids (> 5.0 %): anteiso-C15:0, C16:0, C14:0 and anteiso-C17:0; DNA G+C content: 74.7 %] of strain NEAU-YY56T have also confirmed the affiliation of the isolate to the genus Cellulomonas. However, DNA-DNA relatedness, physiological and biochemical characteristics indicated that strain NEAU-YY56T can be clearly differentiated from its closest relatives. Therefore, it is concluded that strain NEAU-YY56T represents a novel species of the genus Cellulomonas, for which the name Cellulomonas triticagri sp. nov. is proposed. The type strain is NEAU-YY56T (= DSM 106717T = JCM 32550T).
Thyroid Lesions as Diagnosed by Fine-Needle Aspiration Cytology in Uganda: A Five Year Retrospective Study
Authors: Denis Gesa Elly , Lukande Robert , Bukirwa Phiona , Abila Derrick Bary , Boaz Mwesigwa 
Published: February 2022

Abstract
Background
Fine needle aspiration cytology of the thyroid gland has proven to be effective in the categorization of thyroid lesions into benign, atypical, suspicious and malignant categories. However only scanty data has been available regarding the prevalence of thyroid lesions in Uganda. This study aimed at classifying thyroid lesions cytologically and to determine their correlation with the social demographic characteristics.
Methodology:
A laboratory based retrospective study involving a review of 170 cases was conducted at MAKCHS pathology department between 2012 and 2016. FNA results were independently categorized into 4 groups in accordance to Bethesda system for reporting thyroid cytopathology. The data collected was entered using Epidata software and exported to SPSS for analysis.
Results
Out of the 170 cases reviewed, 148 (87.1%) were benign, 3 (1.8%) were suspicious for Follicular Neoplasm, 5 (2.9%) were suspicious of malignancy & 14 (8.2%) were malignant. Colloidal nodule (41.2%) was most prevalent lesion among the benign cases, followed by Follicular adenoma (25.3%). Malignant category was dominated by papillary carcinoma (7.1%). The peak age group for benign lesions was 40–49 years whereas the peak age group for malignant lesions was 40–49 years & 50-59years age group.
Conclusion
The present findings are consistent with those published in other literature with benign lesions showing predominance over the malignant lesions. Sex and age were found to be associated with a specific diagnosis with the females being most affected as well as those in the older groups.
Stakeholder opinions on the structure and development of a new risk of bias tool to assess systematic reviews with network meta-analysis (RoB NMA tool): a cross-sectional survey
Authors: Lunny Carole , Veroniki Areti Angeliki , Hutton Brian , White Ian R , Higgins Julian PT , Wright James M , Kim Ji Yoon , Thirugnanasampanthar Sai Surabi , Siddiqui Shazia , Moja Lorenzo , Taske Nichole , Lorenz Robert , Gerrish Savannah , Straus Sharon , Minogue Virginia , Hu Franklin , Kapani Ayah , Nagi Samin , Chen Lillian , Akbar-nejad Mona , Tricco Andrea C. 
Published: February 2022

Abstract

Introduction: Network meta-analysis (NMA) is increasingly used in guideline development and other aspects of evidence-based decision-making. We engaged with stakeholders in early phases of the development of a new tool to assess risk of bias (RoB) in NMA to facilitate its later use and potentially widen its impact. Methods: We surveyed stakeholders’ views and preferences about the importance, utility, and willingness to use the RoB NMA tool to evaluate evidence in practice and in policymaking. We included 12 closed and 10 open-ended questions, and followed a knowledge translation plan to disseminate the survey through social media and professional networks. Results: A total of 298 stakeholders participated in the survey (14% respondent rate) which took on average 2 minutes to complete. 75% of stakeholders indicated that their organization produced NMAs, and 78% of respondents showed high interest in the tool. Most stakeholders (84%) reported they would use the tool to assess an NMA if they had received adequate training, while half reported they preferred a tool to assess both bias in individual NMA results and authors’ conclusions. Twelve (8%) stakeholders said they would use the tool to conduct an overview of reviews, while 24 (17%) respondents indicated that they would use the tool to distinguish between NMAs at high and low risk of bias. Conclusions: This survey informs the development of a RoB tool for NMAs and is a pillar in an integrated knowledge translation approach. Stakeholders preferred a tool to assess both bias in individual NMA results and authors’ conclusions.
Ultra-radical surgery for advanced ovarian cancer- a retrospective cohort study in a tertiary referral cancer center in the UK
Authors: Palaiologos Konstantinos , Nikoloudaki Zoe , Adedipe Tolu , Booth Susanne , Flynn Marina , Lykoudis Pavlos , Giannopoulos Theodoros 
Published: February 2022

Abstract
Background
Ovarian cancer is the leading cause of death from gynaecological cancer in the UK. The standard of care is a combination of surgery and chemotherapy. The aim of the treatment is the resection of all macroscopic disease. In selected cases of advanced ovarian cancer this is achieved with ultra-radical surgery. However, NICE encourages further research due to low quality evidence on the safety and efficacy of this extensive surgery.
Objective
The aim of this study is to examine the morbidity and survival rates of ultra-radical surgery for advanced ovarian cancer performed in our unit and compare our findings with the current literature.
Methods
This is a retrospective study of 39 patients diagnosed with stage IIIA-IV ovarian and primary peritoneal cancer who underwent surgery in our unit between 2012 and 2020. The main outcome measures were the perioperative complications, the disease-free survival, the overall survival rate and the recurrence rate.
Results
The study enrolled 39 patients with stages IIIA-IV who were treated in our unit between 2012 and 2020. 21 patients were at stage III (53.8%) whereas 18 (46.1%) at stage IV. 14 patients underwent primary and 25 secondary debulking surgery. Major and minor complications occurred 17.9% and 56.4% of the patients, respectively. Complete cytoreduction following surgery was achieved in 24 cases (61.5%). The mean and the median survival time were 4.8 years and 5 years, respectively. The mean disease free survival time was 2.9 years while median disease free survival time was 2 years. Age (p=0.028) and complete cytoreduction (p=0.048) were found to be significantly associated with survival. Primary debulking surgery was significantly associated with lower probability of recurrence (p=0.049).
Conclusion
Although the number of patients is relatively small, our study indicates that ultra-radical surgery in centres with high expertise may result in excellent survival rates with an acceptable rate of major complications. All patients in our cohort were operated by an accredited Gynaecological Oncologist and a Hepatobiliary General Surgeon with a special interest in ovarian cancer. A few cases required input from a Colorectal and a Thoracic Surgeon. We believe that the careful selection of the patients that can benefit from ultra-radical surgery and our model of joint surgery can explain our excellent results. Further research is essential to establish that ultra- radical surgery has an acceptable rate of morbidity for patients with advanced ovarian cancer.
Case detection and management of mobile leprosy in Baoan District, Shenzhen : A retrospective analysis
Authors: Ye Yun-feng , Huang Zhi-ming , Huang Yan-hui , Li Li-mei , Li Jing , Huang Jun-xin , Liu Hu-yin 
Published: February 2022

Abstract
The mobile leprosy control programme in Baoan district was launched in the late 1990s with the goal of elimination of leprosy in mobile population. Here, we aims to describe the characteristics of mobile people suffering from leprosy and the achievements, over the past 30 years in Baoan District, Shenzhen, China, and identified the challenges for better mobile leprosy control. Data from the Leprosy Management Information System in China (LEPMIS) and the annual Leprosy Records were obtained, including patient’s basic demographic information and clinical characteristics. A total of ninety five patients were newly detected from 1991 to 2020, with the new case detection rate per 100,000 ranging from 0.14 to 0.07, while the prevalence rate per 100,000 ranging from 0.48 to 0.37. There were no childhood cases and relapse cases. 83.2% of mobile patients coming from southwestern and mid-southern provinces were detected. The median length of time between symptom onset and diagnosis was 31 months (range, 3-296 months). 61.1% of patients had nerve damage at the time of diagnosis. Ulnar nerve was the most commonly involved nerve in nearly 50.0% of total patients in the study. Nearly one third of patients had a reaction and neuritis at some point. 16.8% had a disability of Grade 2 and 25.3% of Grade 1. Among these deformities, leprosy deformities involving hand were 22(23.2%), feet were 30(31.6%), eye were 4(4.2%), respectively. A total of 76 patients have completed MDT treatment and none of them relapsed. 4 patients were loss to follow-up and 15 patients moved back to their household registered location. The case finding and management of mobile leprosy has made remarkable progress in this area. The challenges for mobile leprosy elimination in the next stage are multi-sectoral coordination, involvement of the whole society, sustainable support and investment form the government, stable professional workforce, regular follow-up and tracking survey, establishing an effective surveillance network and referral system.