bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intussusception Related to Small Intestinal Lipomas: A Case Report and Review of the Literature
Authors: Hu Qiang , Wu Jinfeng , Sun Yuanshui 
Published: June 2022

IntroductionAdult intussusception is a rare disease that is difficult to diagnose and treat and is even rarer when it is caused by a lipoma of the small intestine. We reported a case of a small intestine lipoma combined with intussusception, which can guide people in future clinical work.Case PresentationA 51-year-old female was admitted to the hospital with “abdominal pain for 1 month.” Enhanced computed tomography (CT) of the abdomen suggested a lipoma in the left lower quadrant and a proximal intussusception. After excluding surgical contraindications, laparoscopic exploration was performed on the second day of admission, which showed a small amount of ascites in the abdominal cavity, a small intestine–small intestine-type intussusception about 20 cm from the ileocecal area and about 140 cm from the ileocecal area, and a mass of about 2×4 cm that was palpable by laparoscopic intestinal forceps, which was protruded into the intestinal cavity with a soft texture and sound mobility. A 5 cm-long incision was made above the mass to dissect into the abdomen layer by layer, and the diseased intestine was dislodged outside the abdominal cavity with oval forceps. The intestine was reduced by hand and observed for half an hour after reduction, and the blood circulation and peristalsis of the intestine were observed to be still sound. The intestine was dissected at 2 cm from the upper and lower margins of the mass using linear anastomosis to operate small intestine side-to-side anastomosis. The intestine was opened concurrently and closed with a linear anastomosis, using 3-0 absorbable thread to reinforce anastomosis intermittently. The procedure went smoothly, and the patient was discharged on the 5th postoperative day.ConclusionA small intestinal lipoma combined with small intestinal intussusception is rare in clinical practice and needs to be diagnosed by asking history detailedly, physical examination, and relevant ancillary tests such as abdominal CT. Laparoscopic-assisted small incision surgery for adult intussusception combines the advantages of laparoscopic surgery and laparotomy, operating simply and easily.
The Effect of Increasing Tibial Tuberosity Advancement and Quadriceps Muscle Force on Cranial Translation of the Tibia in the Cranial Cruciate Deficient Stifle Joint in Dogs
Authors: Ober Ciprian , Berger Chen , Cohen Liat , Milgram Joshua 
Published: June 2022

BackgroundCranial cruciate ligament (CCL) disease is a well-known pathology that generates both rotational and translational instability of the stifle joint that leads to osteoarthritis in dogs. Tibial tuberosity advancement (TTA) is a common surgical technique used to dynamically neutralize the tibiofemoral shear forces to achieve stifle joint stability. However, significant persistent instability has been documented in clinical cases. The purpose of this study was to evaluate the effect of increasing quadriceps load, increasing tibial tuberosity advancement, and increasing joint flexion angle on the cranial translation of the tibia relative to the femur in the cranial cruciate ligament deficient stifle joint.Methods and ResultsSix cadaveric hind limbs were collected from six healthy mixed breed dogs of medium build and prepared for biomechanical testing. The specimen was placed into a custom-made joint testing machine, and translation of the tibia relative to the femur was measured at stifle angles of 135°, 120°, and 105°. Cranial tibial thrust was generated by applying a vertical load to the metatarsal pad and the quadriceps muscle was simulated with loads of 0, 5, and 10 kg applied to the patellaviaa system of weights and pulleys. All specimens were tested with the CCL intact and cut, both of which served as controls. The tibial tuberosity was then advanced using both 6 mm and 9 mm cages, and the specimen was tested using the identical technique. Each specimen was loaded to failure by increasing the load applied to the pes until the sudden marked cranial translation of the tibia. Tibial tuberosity advancement with an applied quadriceps load was successful in limiting cranial tibial translation in 54/62 tests. Under similar loading conditions, TTA failed to limit cranial translation in 8 tests. The failures occurred at all angles of flexion examined. In the cases that failed cranial translation could be limited by either increasing the quadriceps load or increasing the amount of tibial tuberosity advancement.ConclusionThis study showed that TTA with an applied quadriceps load is effective at decreasing cranial tibial translation at functional joint angles.
Future Trends in the Treatment of MRSA in Pakistan
Authors: Noorulamin Muhammad Noorulamin , Zarafsah Dr. Zarafshan Badar , Dr. Ayesha Janjua  , Azhar Iqbal  , Dr. Sobia Humerah  , Dr. Pakeeza Arzoo Shaiq  
Published: June 2022

Background: The Methicillin resistant Staphylococcus aureus (MRSA) is accountable for community and hospital acquired infections. Due to over and misuse of antibiotics, MRSA isolates are becoming multidrug resistant even with linezolid and vancomycin. The objective of this study was to determine recent antimicrobial profile of MRSA, isolated from different clinical samples and current treatment options for MRSA, other than vancomycin and Linezolid.
Methodology: This cross-sectional study was conducted at Foundation university medical college from Jan 2019 to Dec 2020. Total 918 samples of blood, pus swab, throat swab, tracheal swab, wound swab, endotracheal tube (ETT) tips, Catheter tips, axillary swab and suction tips received by using aseptic techniques, for culture and sensitivity in different hospitals of Rawalpindi and Islamabad, were taken. Isolated pathogens were identified using standard protocols and susceptibility testing was done by Kirby-Bauer disc diffusion method.
Results: Out of 918 samples, MRSA was isolated in 96 (10.4%) samples and most frequently observed in 27% (n=26) blood samples. The mean age of enrolled patients was 52.02 (SD±16.1) years, the infection was largely seen in age group 46-55(24%) and in 57% (n=52) male population. MRSA showed higher resistance to levofloxacin 78.1% (n=75), ciprofloxacin 75% (n=72), erythromycin 70.8% (n=68) and gentamycin 62.5% (n=60). The susceptibility of older drug chloramphenicol and Trimethoprim-sulfamethoxazole was found 61% & 49% respectively. MRSA isolates were highly susceptible to vancomycin (96.8%), linezolid (89.5%) and teicoplanin (70.85%). Alarmingly, 2.1% (n=2) MRSA isolates showed resistance to vancomycin.
Conclusion:Vancomycin resistant MRSA is a matter of great concern, because of unawareness among health administrative departments and public, self-medication, lack of surveillance system and non-availability of antibiotic policy.
Keywords: Antibiotics, MRSA, Vancomycin, Chloramphenicol
Pengunaan Metode Scrum Dalam Pengembangan Perangkat Lunak: Literature Review
Authors: Rizky Muhamad , Sugiarti Yuni 
Published: June 2022

Abstrack: The use of scrum in software engineering as a system development method is considered effective and quite easy to apply in application development. Many Start-up industries as well as IT companies use this method. In software development, Scrum has an iterative and incremental nature that makes this company able to continue to compete in improving its products in the market. Scrum itself is a method that is not rigid, but a framework whose application can be used in various tools and techniques. The purpose of this research is to find out how to use the scrum method in software development and to find out how to deal with the problem of using scrum which has a complex process. The methodology used in this research is literature study. The results of this study are the use of Scrum in software development can be utilized according to the need to both help and solve existing problems in the framework of software development. In solving problems that exist in Scrum related to such a complex process, the step that needs to be done is to identify the cause of the problem. Which is then continued by discussing the right solution with the team in order to find a way out of every problem that exists in each process.Abstrak: Penggunaan scrum dalam rekayasa perangkat lunak sebagai metode pengembangan sistem dianggap efektif dan cukup mudah diterapkan dalam pengembangan aplikasi. Banyak industri Star-up maupun juga perusahaan TI menggunakan metode ini. Dalam pengembangan perangkat lunak Scrum ini memiliki sifat yang iterative dan juga incremental yang menjadikan perusahaan ini bisa terus bersaing dalam meningkatkan produknya dipasaran. Scrum sendiri merupakan metode yang tidak kaku, melainkan framework yang penerapannya ini bisa digunakan dalam berbagai tools maupun juga teknik. Tujuan penelitian ini adalah untuk mengetahui bagaimana penggunaan metode scrum dalam pengembangan perangkat lunak dan mencari bagaimana langkah menangani permasalahan penggunaan scrum yang memiliki proses yang kompleks. Metodologi yang digunakan dalam penelitian ini adalah studi literatur. Hasil penelitian ini adalah penggunan scrum dalam pengembangan perangkat lunak dapat dimanfaatkan sesuai dengan kebutuhan baik membantu maupun menyelesaikan permasalahan yang ada dalam rangka pengembangan perangkat lunak. Dalam menyelesaikan permasalahan yang ada pada scrum terkait proses yang begitu kompleks, langkah yang perlu dilakukan adalah dengan mengidentifikasi penyebab masalah. Yang kemudian dilanjutkan dengan mendiskusikan solusi yang tepat dengan tim agar mencari jalan keluar dari setiap permasalahan yang ada dalam setiap prosesnya.
Small Claims and the Pursuit of (Digital) Justice: A Tiered Online Dispute Resolution Perspective
Authors: Salehi Sajedeh , Giacalone Marco 
Published: June 2022

This paper investigates the most recent developments in completely online small claims processes as a response to the extreme delays in delivering justice by courts. This study argues that adopting a tiered online dispute resolution (ODR) system design can increase access to justice for individuals by simplifying the processes; reducing excessive procedural length and costs; also expanding accessibility to dispute resolution bodies. The present research also proposes that the COVID-19 pandemic has widely opened a bundle of opportunities for complete digitalisation of small claims procedures at the EU and Member State levels. Nevertheless, it deems necessary to closely monitor the function of these systems to ensure that the digitalised small claims procedures meet the standards of procedural fairness and efficiency of justice, in particular concerning self-represented litigants. Thus, the overall structure of this paper takes the form of four sections. The first part lays out the evolution of ODR in relation to small claims and analysing a tiered ODR system design for these cases. Section II gives an overview of the most prominent operating online small claims processes from a global perspective in the United Kingdom, Canada, China, and the United States. The third section is concerned with the status of online small claims processes and the taken measures at EU and Member States level. The final part provides a discussion on the lessons learnt, the opportunities, and the risks in full digitalisation of small claims processes.
Language Rights and Immigrants: Exploring the notion of language- based discrimination
Authors: Boulos Sonia 
Published: June 2022

This article reevaluates the international law principle of non-discrimination based on language, and its application to persons belonging to immigrant communities. The article criticizes the dichotomy between tolerance-oriented language rights and promotion-oriented language rights. As an alternative, the article suggests that a substantive approach to equality in the enjoyment of basic human rights could give rise to a duty to accommodate the language of immigrants, when the absence of accommodations results in the denial of human rights.
Information system for ontological modelling the subject areas
Authors: Bukharov M. N. 
Published: June 2022

Objectives. The creation of ontologies of subject areas is considered. The goal is to develop a mathematical model of ontology and the information system for ontological modeling. The task is to reduce the complexity of ontological modeling.Methods. As research methods, the theory of hybrid intelligence systems, the theory of sets, elements of mathematical logic, methods for developing the information systems, comparative analysis of information systems, informal analysis of information system were used.Results. Mathematical model of ontology using the concept of metaobject is developed. Ontological modelling based on this model involves specification, conceptualization and formalization. A glossary of terms is being built at the specification stage. At the conceptualization stage, objects in the subject area and their hierarchy are defined, and then connections between objects are identified. In the formalization stage, the metaobjects and the relationships between metaobjects that correspond to objects and the relationships between objects were defined. This is considered as the ontology of the subject area. During the actualization stage, the parameters of subject area objects and their values, classes, subclasses, and instances of classes were defined. Parameters, parameter values, classes, subclasses, and instances of classes are implemented in ontology as metaobjects of relative types. An information system with a unique architecture has been developed, namely a hybrid intelligence system for the automation of ontological modelling.Conclusion. The article conducts a comparative analysis of the developed information system with the systems used today for creation of ontologies. The analysis showed that the information system developed by paper author in most parameters is not inferior to considered systems and at the same time easier to use and expand. The mathematical model of ontology and the information system for ontological modeling of subject areas, developed by author, are tested in practical creation of ontology on ecology. On the basis of the conducted comparative analysis and informal analysis of practical use, it is concluded that ontological modeling with the help of the information system developed by author reduces the labor intensity and decreases the time of ontologies creation.
Evidence for the Late Arrival of Hot Jupiters in Systems with High Host-star Obliquities
Authors: Hamer Jacob H. , Schlaufman Kevin C. 
Published: June 2022

Abstract
It has been shown that hot Jupiters systems with massive, hot stellar primaries exhibit a wide range of stellar obliquities. On the other hand, hot Jupiter systems with low-mass, cool primaries often have stellar obliquities close to zero. Efficient tidal interactions between hot Jupiters and the convective envelopes present in lower-mass main-sequence stars have been a popular explanation for these observations. If this explanation is accurate, then aligned systems should be older than misaligned systems. Likewise, the convective envelope mass of a hot Jupiter’s host star should be an effective predictor of its obliquity. We derive homogeneous stellar parameters—including convective envelope masses—for hot Jupiter host stars with high-quality sky-projected obliquity inferences. Using a thin-disk stellar population’s Galactic velocity dispersion as a relative age proxy, we find that hot Jupiter host stars with larger-than-median obliquities are older than hot Jupiter host stars with smaller-than-median obliquities. The relative age difference between the two populations is larger for hot Jupiter host stars with smaller-than-median fractional convective envelope masses and is significant at the 3.6σ level. We identify stellar mass, not convective envelope mass, as the best predictor of stellar obliquity in hot Jupiter systems. The best explanation for these observations is that many hot Jupiters in misaligned systems arrived in the close proximity of their host stars long after their parent protoplanetary disks dissipated. The dependence of observed age offset on convective envelope mass suggests that tidal realignment contributes to the population of aligned hot Jupiters orbiting stars with convective envelopes.
Microwave-assisted synthesis of bioactive tetrahydropyrimidine derivatives as antidiabetic agents
Authors: Vachhani Mukeshkumar , Lalpara Jaydeep , Hadiyal Sanjay , Dubal Gaurang 
Published: June 2022

Abstract

Introduction: In drug discovery, pyrimidine analogues show good biological response and many drug moieties have pyrimidine core.
Aim: On the basis of prior review, we synthesized a series of N-(substituted phenyl)-1,3,6-trimethyl-4-(4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide parade a 1,3,4-oxadiazole core which were evaluated for in vitro antidiabetic screening.
Materials and methods: The tetrahydropyrimidine derivatives have been synthesized by microwave irradiation method. It was carried out by Biginelli condensation of 1,3,4-oxadiazole based aldehyde, substituted acetoacetanilide and N,N’-dimethyl urea. All synthesized compounds were evaluated for antidiabetic screening.
Results: By the results derived from antidiabetic activity, compounds 4a, 4e, 4g, and 4i show good inhibition compared to others because of electron withdrawing and hydroxyl groups. All results are compared with standard drug acarbose.
Conclusions: In conclusion, a series of 1,3,4-oxadizole bearing tetrahydropyrimidine has been synthesized and evaluated for in vitro antidiabetic screening. The derivatives 4a, 4e, 4g, and 4i exhibited promising antidiabetic activity.
Prognostic models for the development of diffuse idiopathic skeletal hyperostosis
Authors: Geneva-Popova Mariela , Hodzhev Vladimir , Popova-Belova Stanislava 
Published: June 2022

Introduction: Diffuse idiopathic skeletal hyperostosis (DISH) is a common worldwide disease in adults over 50 years of age. The clinical diagnosis at the beginning of the disease is very difficult, even impossible, without typical symptoms and image changes. Mathematical models for searching risk factors include analysing medical history data, comorbidities, biochemical and instrumental results.
Aim: The aim of the study was to analyse the demographic, clinical, biochemical, and imaging findings in patients with DISH and develop prognostic models to help identify risk factors for the disease.
Materials and methods: We analysed 124 patients with diffuse idiopathic skeletal hyperostosis treated at the Clinic of Rheumatology in St George University Hospital, Plovdiv between 2013 and 2020. All biochemical and imaging studies were performed in the facilities of the University Hospital. SPSS, ver. 26 was used for the statistical analysis.
Results: One-way analysis of history and clinical symptoms showed the highest prognostic value with OR&gt;4 for over 50 years, mechanical pain in the thoracic and cervical spine, and Ott’s symptom, OR &gt;3 for Hirz’s symptom, and OR&gt;2 for thoracic spine stiffness, clinical evidence of spine fracture, and the Shober’s symptom. We found that the highest prognostic value for the risk factors of DISH is elevated triglycerides, increased glucose, increased total cholesterol, and increased uric acid (OR over 5).
Conclusions: Our mathematical models determined the risk factors for development of DISH using different variables from the history, laboratory parameters, and imaging studies. These mathematical models are easy to apply and can be used routinely in clinical practice.
Vitamin D supplementation in patients with atopic dermatitis, chronic urticaria and contact irritant and allergic dermatitis – possible improvement without risk
Authors: Lugović-Mihić Liborija , Mandušić Nikolina , Dasović Marina , Pondeljak Nives , Kuna Matea , Pozderac Iva 
Published: June 2022

Abstract

Introduction: There has been a lot of talk lately about the importance of reduced serum vitamin D levels and their supplementation for patients with inflammatory skin diseases such as atopic dermatitis (AD) and other allergic diseases. Serum vitamin D values are associated with a number of factors such as limited sunlight exposure (modern lifestyle, extended indoor stay, enhanced sun protection, etc.) which can affect different diseases.
Aim: To evaluate serum vitamin D values in patients with inflammatory skin diseases, comparing them on the basis of other parameters (age, gender/sex, residential areas, total serum IgE), and establishing whether vitamin D supplementation would affect the improvement of the clinical picture of the disease.
Patients and methods: A total of 157 patients participated in this prospective study: 51 patients with AD, 55 with chronic urticaria (CU) and 51 with contact dermatitis (CD): 38 with irritant CD (ICD) and 13 with allergic CD (ACD). In all patients, the values of serum vitamin D were determined by chemiluminescence microparticle immunoassay (CMIA) and compared by diagnosis, age, sex, living environment, values of total IgE. In patients with reduced values of vitamin D, its supplementation for 3 months was recommended, after which the second evaluation of D vitamin values and disease status were determined and compared with an untreated/unsupplemented group with normal vitamin D values.
Results: Vitamin D deficiency was often observed in patients with AD, CU and CD, most frequently in the ICD group, and least frequently in the ACD group. No significant differences were found in terms of age, gender or living environment, nor was any correlation with total IgE found. In the subjects supplemented with vitamin D, their levels increased significantly and, after its supplementation, improvement of the clinical condition was more common than in the untreated group; however, the differences were not statistically significant (69.8 vs. 58.1, p=0.428).
Conclusions: Although serum vitamin D levels of the groups did not differ significantly, the supplementation of vitamin D in patients with prominent vitamin D deficiency may be useful and crucial for improving the prognosis of the disease.
Disaster medical support plan as an element of the hospital disaster resilience
Authors: Georgieva Mariya , Kostadinov Rostislav , Semerdjieva Mariya 
Published: June 2022

Abstract

Introduction: Every disastrous event, by definition, results in infrastructure damage and a large number of casualties that exceeds the community’s ability to respond effectively and quickly to the human and material losses. The ability to respond quickly, adequately, and effectively in emergency situations, by changing the activities performed and to restore the state of functionality in a short time before disaster is defined as hospital disaster resilience. In order for disaster resilience to be granted for effective and adequate disaster response, the medical staff has to be aware of and trained on medical specialists’ activities described in the disaster medical support plan.
Aim: To analyse the medical professionals’ awareness of hospital disaster medical support plan and its impact on the disaster resilience.
Materials and methods: A 55-question anonymous survey was conducted among 295 hospital professionals in Plovdiv Region between July and September 2019. The respondents were questioned about their awareness of the medical activities described in the hospital disaster medical support plan. Descriptive statistics was used to calculate the relative percentages, along with the Pearson chi-square test and Spearman’s correlation. All descriptive and analytical analyses were performed using SPSS v. 21 for Windows XP.
Results: Thoroughly performed analyses of the respondents’ answers presents that the medical specialists in Plovdiv Region are not well informed about the hospital disaster medical support plan’s content.
Conclusions: Poor knowledge about the required changes into every medical specialist’s activities in case of a disaster has a negative impact on the hospital resilience.