bluuebunny/crossref_metadata_2025_split huggingface dataset:
En estricto aislamiento: La invasión estadounidense y la medicalización de la lepra en Puerto Rico, 1898–1903
Authors: Salcedo-Chirinos César Augusto 
Published: September 2022

ResumenEn este artículo se analizan las circunstancias históricas en las cuales cambiaron, tanto el discurso médico como la atención que se daba a las personas con lepra en Puerto Rico. Se toma como punto de partida la invasión estadounidense de 1898 y su proyecto de transformación de la salud pública de la isla. Como parte de estos cambios se identifica un nuevo modelo de atención para los contagiados, basado en la idea del aislamiento. De esta manera, las autoridades sanitarias se distanciaban de la teoría de la herencia, la que se había manejado con anterioridad a esa fecha. Se argumenta que ese aislamiento fue expresión de la política colonialista del momento. Se quiere mostrar que la rigurosidad del nuevo modelo de atención transformó la vida de aquellos enfermos, los cuales pasaron de convivir con sus familias, a recluirse en un islote. Este proceso de transformación fue iniciado particularmente por los médicos del Marine Hospital Service.
Crust–mantle interactions in Zijinshan ore field identified by zircon SIMS U–Pb age and zircon Hf–O isotopes
Authors: Zhang Wen-Hui , Yan Shuai-Qi , Wang Li-Yuan 
Published: September 2022

AbstractThis study presents zircon U–Pb geochronology and Hf and O isotope data for granitic rocks in the Zijinshan ore field, southwestern Fujian Province, China. The intrusive rocks comprise monzogranite, granite and granodiorite. The magmatic zircon U–Pb ages from these granitic rocks can be divided into four episodes: episodes 1 (157.9–159.9 Ma) and 2 (141 Ma) in the Late Jurassic and episodes 3 (108.1–103.2 Ma) and 4 (97.5–99.7 Ma) in the Middle and Late Cretaceous, respectively. Patterns of rare-earth elements (REE) show enrichment in light REE and obvious negative Eu anomalies. These rocks are also enriched in Rb, Th, U, La, Ce, Nd and Hf, and depleted in Ba, Nb, Sr, P and Ti. The increasing La/Yb ratio and decreasing heavy REE content with decreasing age may imply an increasing contribution of mantle-derived materials from the Late Jurassic to Cretaceous. The zircon ϵHf(t) and δ18O values, ranging from −37.7 to −2.8 and 12.0 ‰ to 6.3 ‰, respectively, indicate that the lower crust is an important source of granitic rocks. There was a significant increase in ϵHf(t) values and a decrease in δ18O values in the younger magmatic episodes (3 and 4), which ranged from −11.4 to −0.6 and 10.7 to 6.3 ‰, respectively. This suggests an increasing contribution of mantle-derived magma to the crustal melts from the Late Jurassic to late Early Cretaceous in response to the changing regional tectonic setting from compression to extension and an increasing interaction between the crust and mantle.
CONSTITUTIONAL TRADITIONS AS BOUNDARIES IN STANDARDISING ADMINISTRATIVE RULEMAKING THROUGH TRADE AGREEMENTS
Authors: Liu Han-Wei , Lin Ching-Fu 
Published: September 2022

AbstractPioneered by the US, recent mega-regional trade agreements such as the CPTPP have incorporated ‘regulatory coherence’ provisions—mirroring the US Administrative Procedural Act's core designs—to balance between domestic regulatory autonomy and international cooperation. Building upon existing literature that traces the trajectories of the diffusion of regulatory coherence across jurisdictions, this article analyses how Australia's constitutional tradition could effectively condition the development of regulatory coherence in a Westminster-based model of governance. It is argued that the global entrenchment of regulatory coherence is contingent upon the inherent boundary defined by the political dynamics and constitutional structures within a jurisdiction.
Grete Mostny and the Making of Indigenous Archaeology: European Immigration, White Racial Hegemony, and Chilean Nationalism
Authors: Erker Linda 
Published: September 2022

AbstractForced migration as a reaction to National Socialism represents individual as well as simultaneously collective, transnational, and global experiences. Not only identity-forming categories but also forms of knowledge are profoundly reshaped by processes of displacement and resettlement. The paper argues that the biography of the archaeologist Grete Mostny (1914–91) offers an exemplary case study of such processes of adaptation on individual, collective, and academic levels. Due to her escape from Austria to Chile as a persecuted Jew in 1938/39, Mostny's identity as a white European (female) scholar attained a whole new significance and became the door opener for her interdisciplinary career at the interface of archaeology and anthropology in her new homeland. Her research in Chile was a product of a global event—namely mass forced emigration from Europe—as well as of factors on the micro level, such as her European descent and her academic education, which gave her certain privileges in her new environment. When Mostny arrived in Chile in 1939, a new European and U.S. hegemony had already begun to dominate academia in the country, which was trying to modernise itself and move from the academic periphery closer to the centre. Mostny, the once racially persecuted scholar, fit well in this process by making use of her “European” knowledge and her networks. In 1954 she received international attention when she put together a pioneering interdisciplinary research team to study El Niño del Cerro El Plomo, a four-hundred-year-old Inca mummy found in the Andes five thousand metres above sea level. Nationally, Mostny's study contributed, beyond all measure, to the Andean state's identity, as it re-evaluated and enhanced Chile's prehistory. In a time of political and social tensions in Chile, the rediscovery of its Indigenous prehistory—even by a foreign white scholar—helped to overcome the old shadows of colonial historical research, perhaps because in the immediate present the Indigenous movement in Chile offered little potential for consensus. This article uses Mostny's transnational biography as a lens through which to detect these connected histories and entangled hegemonies in the fields of anthropology and archaeology, which have become instrumental in the formation of Chile's national identity. Moreover, the paper shows that the category of race played a central role in the field of knowledge production and career development, not only for Grete Mostny.
“One China” and the Cross-Taiwan Strait Commitment Problem
Authors: Lin Dalton 
Published: September 2022

AbstractFifty years after the current “one China” framework emerged in international politics, the cross-Taiwan Strait “one China” dispute has transformed from its historical nature of indivisible sovereignty. As Taipei has stopped competing internationally to represent “China” since 1991, Beijing now worries that compromising its “one-China principle” in cross-Strait reconciliation would enhance Taiwan's separate statehood internationally and enable the island to push towards de jure independence. In contrast, Taipei worries that any perceived concessions on the question of “one China” would enhance China's sovereignty claim over Taiwan and enable Beijing to push for unification coercively with fewer concerns about international backlash. Improved cross-Strait relations thus rely on circumventing this quintessential commitment problem in international politics.
Multi-nutrient interventions and cognitive ageing: are we barking up the right tree?
Authors: Young Hayley A , Geurts Lucie , Scarmeas Nikolaos , Benton David , Brennan Lorraine , Farrimond Jonathan , Kiliaan Amanda J. , Pooler Amy , Trovò Laura , Sijben John , Vauzour David 
Published: September 2022

AbstractAs we continue to elucidate the mechanisms underlying age-related brain diseases, the reductionist strategy in nutrition–brain function research has focused on establishing the impact of individual foods. However, the biological processes connecting diet and cognition are complex. Therefore, consideration of a combination of nutritional compounds may be most efficacious. One barrier to establishing the efficacy of multi-nutrient interventions is that the area lacks an established set of evidence-based guidelines for studying their effect on brain health. This review is an output of the International Life Sciences Institute (ILSI) Europe. A multi-disciplinary expert group was assembled with the aim of developing a set of considerations to guide research into the effects of multi-nutrient combinations on brain functions. Consensus recommendations converged on six key issues that should be considered to advance research in this area: (1) establish working mechanisms of the combination and contributions of each individual compound; (2) validate the relevance of the mechanisms for the targeted human condition; (3) include current nutrient status, intake or dietary pattern as inclusion/exclusion criteria in the study design; (4) select a participant population that is clinically and biologically appropriate for all nutritional components of the combination; (5) consider a range of cognitive outcomes; (6) consider the limits of reductionism and the ‘gold standard’ randomised controlled trial. These guiding principles will enhance our understanding of the interactive/complementary activities of dietary components, thereby strengthening the evidence base for recommendations aimed at delaying cognitive decline.
Evaluating the Evolution of ECMWF Precipitation Products Using Observational Data for Iran: From ERA40 to ERA5
Authors: Ghajarnia Navid , Akbari Mahdi , Saemian Peyman , Ehsani Mohammad Reza , Hosseini‐Moghari Seyed‐Mohammad , Azizian Asghar , Kalantari Zahra , Behrangi Ali , Tourian Mohammad J. , Klöve Björn , Haghighi Ali Torabi 
Published: September 2022

AbstractEuropean Center for Medium‐Range Weather Forecasts Reanalysis (ERA), one of the most widely used precipitation products, has evolved from ERA‐40 to ERA‐20CM, ERA‐20C, ERA‐Interim, and ERA5. Studies evaluating the performance of individual ERA products cannot adequately assess the evolution of the products. We compared the performance of all ERA precipitation products at daily, monthly, and annual data (1980–2018) using more than 2100 Iran precipitation gauges. Results indicated that ERA‐40 performed worst, followed by ERA‐20CM, which showed only minor improvements over ERA‐40. ERA‐20C considerably outperformed its predecessors, benefiting from the assimilation of observational data. Although several previous studies have reported full superiority of ERA5 over ERA‐Interim, our results revealed several shortcomings in ERA5 compared with the ERA‐Interim estimates. Both ERA‐Interim and ERA5 performed best overall, with ERA‐Interim showing better statistical and categorical skill scores, and ERA5 performing better in estimating extreme precipitations. These results suggest that the accuracy of ERA precipitation products has improved from ERA‐40 to ERA‐Interim, but not consistently from ERA‐Interim to ERA5. This study employed a grid‐grid comparison approach by first creating a gridded reference data set through the spatial aggregation of point source observations, however, the results from a point‐grid approach showed no change in the overall ranking of products (despite the slight changes in the error index values). These findings are useful for model development at a global scale and for hydrological applications in Iran.
Multilayer CVD graphene electrodes using a transfer-free process for the next generation of optically transparent and MRI-compatible neural interfaces
Authors: Bakhshaee Babaroud Nasim , Palmar Merlin , Velea Andrada Iulia , Coletti Chiara , Weingärtner Sebastian , Vos Frans , Serdijn Wouter A. , Vollebregt Sten , Giagka Vasiliki 
Published: September 2022

AbstractMultimodal platforms combining electrical neural recording and stimulation, optogenetics, optical imaging, and magnetic resonance (MRI) imaging are emerging as a promising platform to enhance the depth of characterization in neuroscientific research. Electrically conductive, optically transparent, and MRI-compatible electrodes can optimally combine all modalities. Graphene as a suitable electrode candidate material can be grown via chemical vapor deposition (CVD) processes and sandwiched between transparent biocompatible polymers. However, due to the high graphene growth temperature (≥ 900 °C) and the presence of polymers, fabrication is commonly based on a manual transfer process of pre-grown graphene sheets, which causes reliability issues. In this paper, we present CVD-based multilayer graphene electrodes fabricated using a wafer-scale transfer-free process for use in optically transparent and MRI-compatible neural interfaces. Our fabricated electrodes feature very low impedances which are comparable to those of noble metal electrodes of the same size and geometry. They also exhibit the highest charge storage capacity (CSC) reported to date among all previously fabricated CVD graphene electrodes. Our graphene electrodes did not reveal any photo-induced artifact during 10-Hz light pulse illumination. Additionally, we show here, for the first time, that CVD graphene electrodes do not cause any image artifact in a 3T MRI scanner. These results demonstrate that multilayer graphene electrodes are excellent candidates for the next generation of neural interfaces and can substitute the standard conventional metal electrodes. Our fabricated graphene electrodes enable multimodal neural recording, electrical and optogenetic stimulation, while allowing for optical imaging, as well as, artifact-free MRI studies.
ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling
Authors: Zhao Guangjie , Li Shuang , Wang Qian , Wu Wanlin , Fu Xuewei , Zhu Chen , Wang Wei , Wang Xiaoqin 
Published: September 2022

AbstractThe factors that affect hypomethylating agents (HMAs) sensitivity in myelodysplastic syndrome (MDS) are complex and multifaceted. They include DNA methylation, gene expression, mutation, etc. However, the underlying mechanisms are still not clearly illustrated. In the present work, ABAT gene expression was associated with HMAs sensitivity. It was found that ABAT gene interference increased the sensitivity of HL-60 and THP-1 cells to HMAs treatment, while ABAT overexpression decreased its sensitivity. RNA-sequencing analysis showed that ABAT knockdown activated both interferon I and interferon-gamma signaling while inhibiting the secondary metabolic synthesis and arginine metabolic process. Gas chromatography-mass spectrometry (GC-MS) based metabolic profiling also demonstrated that ABAT gene knockdown affected arginine, alanine, aspartate, and glutamate metabolism, in addition to the biosynthesis of valine, leucine, and isoleucine, and the metabolism of beta-alanine. The ABAT gene expression downregulation could activate the CXCR4/mTOR signaling pathway, which was related to HMAs sensitivity. CXCR4 expression was regulated by mTOR activity and vice versa. In vivo, mice injected with ABAT gene knockdown cells lived longer than control mice after HMAs treatment. Overall, this study elucidates the novel regulatory mechanisms of HMAs sensitivity and provides a potential therapeutic target in MDS.
A critical review of the recent advances in inclusion-triggered localized corrosion in steel
Authors: Liu Pan , Zhang Qin-Hao , Watanabe Yutaka , Shoji Tetsuo , Cao Fa-He 
Published: September 2022

AbstractLocalized corrosion triggered by inclusions is prone to metallic material failure. Except for chemical dissolution of some special inclusions, the principle of galvanic coupling is the most acceptable theory to explain the above corrosion damage mechanism over the past decades. Still, controversies continue to present, in particular, mounting recent evidence obtained by advanced technologies emphasizes the limitations of previous entrenched idea and discloses unexpected results. Here, we review relevant recent studies and carefully summarize their similarities and differences to reduce the knowledge gap between inclusion-triggered localized corrosion and material design, whilst the source of typical inclusions is treated and discussed.
Free-running long-distance reference-frame-independent quantum key distribution
Authors: Tang Bang-Ying , Chen Huan , Wang Ji-Peng , Yu Hui-Cun , Shi Lei , Sun Shi-Hai , Peng Wei , Liu Bo , Yu Wan-Rong 
Published: September 2022

AbstractRapidly and randomly drifted reference frames will shorten the transmission distance and decrease the secure key rate of realistic quantum key distribution (QKD) systems. In this article, we present a free-running reference-frame-independent (RFI) QKD scheme, where measurement events are classified into multiple slices with similar estimated classification parameter. We perform the free-running RFI QKD experiment with a fiber link of 100 km and reference frame misalignment more than 29 periods in 50.7 h. A key rate as high as 742.98 bps is achieved at the total loss of 31.5 dB benefiting from both the new protocol design and the 80 MHz repetition rate system in use. Our system runs 50.7 h freely without any reference frame alignment. In the experiment, the misalignment variation rate tolerance of the experiment is 0.262 rad/s, and could be optimized to 1.309 rad/s. Therefore, our free-running RFI scheme can be efficiently adapted into the satellite-to-ground and drone-based mobile communication scenarios.
Strain-specific impacts of probiotics are a significant driver of gut microbiome development in very preterm infants
Authors: Beck Lauren C. , Masi Andrea C. , Young Gregory R. , Vatanen Tommi , Lamb Christopher A. , Smith Rachel , Coxhead Jonathan , Butler Alana , Marsland Benjamin J. , Embleton Nicholas D. , Berrington Janet E. , Stewart Christopher J. 
Published: September 2022

AbstractThe development of the gut microbiome from birth plays important roles in short- and long-term health, but factors influencing preterm gut microbiome development are poorly understood. In the present study, we use metagenomic sequencing to analyse 1,431 longitudinal stool samples from 123 very preterm infants (<32 weeks’ gestation) who did not develop intestinal disease or sepsis over a study period of 10 years. During the study period, one cohort had no probiotic exposure whereas two cohorts were given different probiotic products: Infloran (Bifidobacterium bifidumandLactobacillus acidophilus) or Labinic (B. bifidum, B. longumsubsp.infantisandL. acidophilus). Mothers’ own milk, breast milk fortifier, antibiotics and probiotics were significantly associated with the gut microbiome, with probiotics being the most significant factor. Probiotics drove microbiome transition into different preterm gut community types (PGCTs), each enriched in a differentBifidobacteriumsp. and significantly associated with increased postnatal age. Functional analyses identified stool metabolites associated with PGCTs and, in preterm-derived organoids, sterile faecal supernatants impacted intestinal, organoid monolayer, gene expression in a PGCT-specific manner. The present study identifies specific influencers of gut microbiome development in very preterm infants, some of which overlap with those impacting term infants. The results highlight the importance of strain-specific differences in probiotic products and their impact on host interactions in the preterm gut.
New insights into detecting alizarin from autofluorescence in marked glass eels
Authors: Gaillard Mélanie , Parlanti Edith , Sourzac Mahaut , Couillaud Franck , Genevois Coralie , Boutry Sébastien , Rigaud Christian , Daverat Françoise 
Published: September 2022

AbstractAlizarin detection in fish fins is extensively employed because it is easy to use. However, in eels, the eelGFP fluorescent protein may impede the detection of the fluorescent markers in the eel tissues. The study tests the effectiveness of three of the most up-to-date alizarin-detecting technologies on the living body and fins of European glass eels (Anguilla anguilla L.). The findings demonstrated that the control group had a high autofluorescence at alizarin and eelGFP maxima bands. With fluorescence reflectance imaging (FRI), the eel living body autofluorescence impeded the detection of the marked eels. In contrast with experimental excitation-emission-matrix (EEM) fluorescence analyses, 99% of the marked eels were correctly assigned to their group from fluorescence analyses of their fin cellular contents. With epifluorometry (EPI), 100% of the marked eels were detected with the caudal fin tips when excited at 450–490 nm wavelengths due to a weaker autofluorescence signal. EEM and FRI assays unveiled an average fluorescence quenching 60% and 44% of the marked group respectively, in the alizarin and eelGFP maxima bands. The fluorescence quenching observed is discussed. Results will benefit experimental design by examining autofluorescence effects on mark detection and the development of non-invasive detection methods in this critically endangered species.
Effect of Controlling Nutritional Status Score (CONUT) and Prognostic Nutritional Index (PNI) on patients after spinal tuberculosis surgery
Authors: Cao Long-Yao , Cheng Si , Lin Lu , Chen Ming-Xin 
Published: September 2022

AbstractThe controlling nutritional status (CONUT) score and prognostic nutrition index (PNI) are immune-nutritional biomarkers that are related to clinical prognosis. Previous studies have reported using them to predict the prognosis of traumatic brain injury, tumours and other diseases. The purpose of this study was to evaluate the relationship between the PNI and CONUT score and the one-year prognosis of patients with spinal tuberculosis (STB). In this study, the clinical characteristics of 97 patients with STB who underwent debridement and internal fixation at our institution between 2015 and 2020 were retrospectively analysed. According to the receiver operating characteristic (ROC) curve, patients were divided into two groups: a high CONUT group and a low CONUT group. Patients were also divided into a high PNI group and a low PNI group. One-year postoperative prognosis was evaluated by the clinical cure standard. Patients in the favourable group were younger and had a lower rate of pneumonia and urinary tract infection, higher PNI and lower CONUT score than those in the favourable group (P < 0.05). There was an obvious correlation between the PNI and CONUT score (r = − 0.884, P < 0.05). The areas under the curve (AUCs) of the CONUT score and PNI for predicting unfavourable prognosis were 0.888 (95% CI 0.808–0.943, P < 0.001) and 0.896 (95% CI 0.818–0.949, P < 0.001), respectively. The adjusted odds ratios (ORs) of the CONUT score and PNI for predicting unfavourable outcomes were 2.447 (95% CI 1.518–4.043, P < 0.001) and 0.689 (95% CI 0.563–0.843, P < 0.001), respectively. Higher CONUT scores and a lower PNI were associated with adverse outcomes in patients with spinal tuberculosis, and the CONUT score and PNI might be independent predictors of adverse outcomes of spinal tuberculosis postoperatively.