bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT and MRI characterization of presumed persistent ossiculum terminale in dogs
Authors: Bourbos Alexandros , Rowan Conor , Cinti Filippo , Pisani Guido , Piola Valentina 
Published: September 2022

AbstractAnecdotally, during the review of CT and MRI studies of canine patients including the cranial cervical spine, authors have identified a small osseous structure between the atlas (C1) and axis (C2) with no relevant clinical signs. This structure appeared comparable to a “persistent ossiculum terminale” in humans. The aim of this retrospective, multi‐center, case series study was to describe the CT and MRI features of presumed persistent ossiculum terminale in a group of dogs presented with unrelated medical conditions. Two databases (the imaging database of the teleradiology service VetCT Specialists and the clinical database of the University of Vienna) were scrutinized by different approaches. Medical records of dogs that underwent imaging investigation (CT and/or MRI) that included the atlanto‐axial junction were reviewed. Data collected included signalment, sex, breed, age, presenting symptoms, and final diagnosis. Eighteen dogs met the inclusion criteria. Mean age was 85 months (6–166) and breed variation was present. A total of 20 imaging studies were evaluated: CT was performed in 17 dogs; MRI in three dogs; two dogs had both MRI and CT performed. In all cases the presence of at least one small osseous body on the cranial aspect of the odontoid process compatible with a persistent ossiculum terminale was identified as a possible incidental finding without any overt clinical implications. Findings indicated that a small osseous body on the cranial aspect of the odontoid process (presumed persistent ossiculum terminale) in CT and MRI studies may be present in dogs with no clinical signs of neurologic disease.
Ultrasonographic and contrast‐enhanced CT imaging diagnosis of idiopathic renal hematuria with bilateral hydronephrosis and hydroureter in a dog
Authors: Choi Mihyun , Kim Yongsun 
Published: September 2022

AbstractA 5‐year‐old spayed female Maltese presented with a 1‐week history of severe hematuria. Abdominal ultrasonography and thoracic, and abdominal computed tomography identified bilateral hydronephrosis and hydroureter due to an obstruction at the left ureter and urinary bladder lesion with no evidence of metastasis. After surgical removal of the material and placement of a temporary ureteral stent, the patient was able to urinate normally. Histological examination revealed a massive blood clot. Based on our review of the literature, this is the first published report describing the imaging diagnosis of obstructive hydronephrosis and hydroureter induced by idiopathic renal hematuria in a dog.
Digital divide among individuals with acquired brain injury: a scoping review protocol
Authors: Chuah Sarah L. , Whiting Diane L. , Simpson Grahame K. 
Published: September 2022

Objective:
This scoping review will identify literature pertaining to individuals with an acquired brain injury and digital divide; specifically, examining personal access and use of internet-enabled information and communication technologies. The review will identify the information and communication technologies used by individuals with an acquired brain injury as well as the determinants of technology use. The review will also identify and create a taxonomy of information and communication technologies utilized in relation to cognitive and psychosocial outcomes for individuals with an acquired brain injury in community and outpatient settings.

Introduction:
Internet-enabled technologies are increasingly central to all aspects of living, including health care and community participation; however, gaps in the access to and use of information and communication technologies among individuals with an acquired brain injury may limit the utility of a digitalized society.

Inclusion criteria:
Studies that focus on access to or use of internet-enabled information and communication technologies among individuals with an acquired brain injury (including stroke, infection, tumor, disease, hypoxia, or traumatic brain injury) will be considered in this review.

Methods:
Primary peer-reviewed studies published in English from 2001 onward will be considered for inclusion. Six electronic databases will be searched: Embase, MEDLINE, Web of Science Core Collection, Google Scholar, CINAHL, and APA PsycINFO. Gray literature searches for government and nongovernment organization reports and data, and dissertation theses will be conducted via advanced Google searches. Two reviewers will independently screen titles, abstracts, and full texts of articles based on the “population, concept, context” inclusion criteria. Relevant data will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR).
Psychosocial interventions that facilitate adult cancer survivors’ reintegration into daily life after active cancer treatment: a scoping review protocol
Authors: Murnaghan Sarah , Scruton Sarah , Urquhart Robin 
Published: September 2022

Objective:
This scoping review will map the extent and type of evidence related to psychosocial supports and interventions that facilitate adult cancer survivors’ reintegration into daily life and activities after active cancer treatment.

Introduction:
Cancer and its treatment have substantial late and long-term adverse impacts on survivors despite enhanced prospects for survival. Cancer survivors have unmet psychosocial care needs, and recent studies show a lack of focus in survivorship research on outcomes important to survivors. Reintegration is an emerging concept, identified as important to cancer survivors, that focuses on returning to a “new normal” after cancer treatment. This study will explore the available evidence on psychosocial interventions that are targeted toward this outcome.

Inclusion criteria:
The population of interest is adult survivors (18 years and older at diagnosis) of any cancer type. Concepts of interest include psychosocial interventions targeting the outcome and reintegration into daily life after cancer treatment. Interventions addressing clinical depression or anxiety and interventions treating physical needs that are largely medically focused will be excluded.

Methods:
A scoping review of the literature will be conducted in MEDLINE, CINAHL, and Embase. Gray literature will be searched using ProQuest Dissertations and Theses. Studies will be screened at the title/abstract and full-text levels, and data will be extracted by 2 independent reviewers. Disagreements that cannot be resolved will be settled by a third reviewer. Findings will be summarized narratively and in tabular format.

Scoping review registration:
Open Science Framework (https://osf.io/r6bmx)
Thermal brachistochrone for harmonically confined Brownian particles
Authors: Patrón Antonio , Prados Antonio , Plata Carlos A. 
Published: September 2022

AbstractThe overdamped Brownian dynamics of a harmonic oscillator is a paradigmatic system in non-equilibrium statistical mechanics, which reliably models relevant stochastic systems such as colloidal particles submitted to optical confinement. In this work, optimal thermal protocols are tailored to minimise the connection time between equilibrium states of overdamped d-dimensional oscillators. Application of control theory reveals that these optimal protocols are of bang-bang type, that is, the temperature of the bath has to take alternatively the minimum and maximum values allowed. Minimum connection times increase with the considered dimension d. Remarkably, this is the case even for symmetric oscillators, for example, with spherical symmetry—in which the degeneracy of the elastic constant along the d possible directions seems to imply a minimum connection time equal to that for the one-dimensional case. This surprising unavoidable price to pay when increasing dimension is thoroughly investigated and understood on a physical basis. Moreover, information theory tools such as the thermodynamic length and its divergence are analysed over the brachistochrone.
1-to-1 or 1-to-n? Investigating the Effect of Function Inlining on Binary Similarity Analysis
Authors: Jia Ang , Fan Ming , Jin Wuxia , Xu Xi , Zhou Zhaohui , Tang Qiyi , Nie Sen , Wu Shi , Liu Ting 
Published: September 2022

Binary similarity analysis is critical to many code-reuse-related issues, where function matching is its fundamental task. “1-to-1” mechanism has been applied in most binary similarity analysis works, in which one function in a binary file is matched against one function in a source file or binary file. However, we discover that the function mapping is a more complex problem of “1-to-n” (one binary function matches multiple source functions or binary functions) or even “n-to-n” (multiple binary functions match multiple binary functions) due to the existence offunction inlining, different from traditional understanding.In this article, we investigate the effect of function inlining on binary similarity analysis. We carry out three studies to investigate the extent of function inlining, the performance of existing works under function inlining, and the effectiveness of existing inlining-simulation strategies. Firstly, a scalable and lightweight identification method is designed to recover function inlining in binaries. 88 projects (compiled in 288 versions and resulting in 32,460,156 binary functions) are collected and analyzed to construct four inlining-oriented datasets for four security tasks in the software supply chain, including code search, OSS (Open Source Software) reuse detection, vulnerability detection, and patch presence test. Datasets reveal that the proportion of function inlining ranges from 30–40% when using O3 and sometimes can reach nearly 70%. Then, we evaluate four existing works on our dataset. Results show most existing works neglect inlining and use the “1-to-1” mechanism. The mismatches cause a 30% loss in performance during code search and a 40% loss during vulnerability detection. Moreover, most inlined functions would be ignored during OSS reuse detection and patch presence test, thus leaving these functions risky. Finally, we analyze two inlining-simulation strategies on our dataset. It is shown that they miss nearly 40% of the inlined functions, and there is still a large space for promotion. By precisely recovering when function inlining happens, we discover that inlining is usually cumulative when optimization increases. Thus, conditional inlining and incremental inlining are recommended to design a low-cost and high-coverage inlining-simulation strategy.
Abstract A21: Novel autochthonous mouse models as preclinical tools in the study of MCD/C5 DLBCL
Authors: Fluemann Ruth , Hansen Julia , Pelzer Benedikt , Lohmann Tim , Kisis Ilmars , Büttner Reinhard , Persighel Thorsten , Abedpour Nima , Peifer Martin , Jachimowicz Ron Daniel , Reinhardt Hans Christian , Knittel Gero 
Published: September 2022

Abstract
Diffuse large B cell lymphoma (DLBCL) is a clinically and genetically very heterogeneous disease. Several [GK1] [RW2] recent studies attempted to give structure to the genetic heterogeneity by clustering cases based on their mutational profiles. Clusters MCD by Schmitz et al. and C5 by Chapuy et al. are amongst the clusters enriched for cases with particularly inferior prognosis. Both clusters are defined by mutations in MYD88 and CD79B as well as high levels of BCL2 expression and recurring mutations in transcriptional regulators of the plasmacytic differentiation process (PRDM1, SPIB). We have generated genetically-engineered mouse models that mimic key alterations of MCD/C5 DLBCL: Hallmark mutations in MYD88 and CD79B, loss of PRDM1 and overexpression of BCL2/SPIB. We could show that those mice develop clonal lesions, which morphologically resemble DLBCL. In the presence of a lesion that prevents plasmacytic differentiation (overexpression of Spib, loss of Prdm1), the forming lesions display signs of an earlier stage of B cell development, specifically histologic and transcriptomic similarities to germinal center cells. In contrast, allelic combinations without differentiation block lead to lymphomas that express CD138 and lack B220 expression, suggesting a more plasmacytic/plasmablastic differentiation status. The presence or absence of a Cd79b p.Y195H mutation has no notable effect on the immunophenotype of the lymphoma. However, its presence correlates with enrichment of BCR signaling gene set expression in lymphoma tissue and significantly increased sensitivity to inhibition of Bruton’s Tyrosine Kinase (BTK) by ibrutinib in our model systems. Taken together, we have established a set of murine models which mimic different genetic features of C5/MCD DLBCL. We have extensively characterized these models and show their usability as preclinical tools for therapeutic studies.
Citation Format: Ruth Fluemann, Julia Hansen, Benedikt Pelzer, Tim Lohmann, Ilmars Kisis, Reinhard Büttner, Thorsten Persighel, Nima Abedpour, Martin Peifer, Ron Daniel Jachimowicz, Hans Christian Reinhardt, Gero Knittel. Novel autochthonous mouse models as preclinical tools in the study of MCD/C5 DLBCL [abstract]. In: Proceedings of the Third AACR International Meeting: Advances in Malignant Lymphoma: Maximizing the Basic-Translational Interface for Clinical Application; 2022 Jun 23-26; Boston, MA. Philadelphia (PA): AACR; Blood Cancer Discov 2022;3(5_Suppl):Abstract nr A21.
Abstract A22: Cost effectiveness of second line Axicabtagene ciloleucel in relapsed refractory diffuse large B-cell lymphoma
Authors: Kambhampati Swetha , Saumoy Monica , Schneider Yecheskel , Budde Lihua E. , Danilov Alexey , Mei Matthew , Popplewell Leslie , Siddiqi Tanya , Zain Jasmine , Forman Stephen , Kwak Larry , Rosen Steven , Herrera Alex , Thiruvengadam Nikhil 
Published: September 2022

Abstract
Background In patients with relapsed/refractory diffuse large B-cell lymphoma (RR-DLBCL), CAR T has been shown to be effective in patients with at least 2 prior lines of therapy. ZUMA-7 study demonstrated that axi-cel improved event free survival (EFS) compared to standard of care (SOC) salvage chemoimmunotherapy in primary refractory/early relapse DLBCL leading to its recent FDA approval in this setting. We evaluated the cost effectiveness of second line axi-cel. Methods We modeled a hypothetical cohort of US adults (mean age, 65 years) with primary refractory/early relapse DLBCL by developing a Markov model (20-year horizon) to model the cost-effectiveness of axi-cel in the second-line setting compared to SOC using a range of plausible long-term outcomes. EFS and OS were estimated from ZUMA-7. Outcome measures were reported in incremental cost-effectiveness ratios, with a willingness-to-pay (WTP) threshold of $150,000/quality-adjusted life-year (QALY). Results Assuming a 5-year EFS of 35% with second line axi-cel and 10% with SOC, axi-cel was cost-effective at a WTP of 100,000 and 150,000 ($93,547/QALY). Axi-cel was no longer cost effective if its 5-year EFS was 26.4% or lower. One-way sensitivity analysis demonstrated that second-line CAR T is cost effective up to a cost of $972,061 at a WTP of $150,000. Second-line axi-cel was the cost-effective strategy in 73% of the 10,000 Monte-Carlo iterations at a WTP of $150,000. Conclusions If the absolute benefit in EFS is maintained over time, second line axi-cel for aggressive RR-DLBCL is cost effective when compared to SOC at WTPs of $100,000 and $150,000/QALY. However, its cost effectiveness is highly dependent on long-term outcomes. Routine usage of second-line CAR T would add significantly to healthcare expenditures even when used in a high-risk subpopulation. Further reductions in cost of CAR T are needed.
Citation Format: Swetha Kambhampati, Monica Saumoy, Yecheskel Schneider, Lihua E. Budde, Alexey Danilov, Matthew Mei, Leslie Popplewell, Tanya Siddiqi, Jasmine Zain, Stephen Forman, Larry Kwak, Steven Rosen, Alex Herrera, Nikhil Thiruvengadam. Cost effectiveness of second line Axicabtagene ciloleucel in relapsed refractory diffuse large B-cell lymphoma [abstract]. In: Proceedings of the Third AACR International Meeting: Advances in Malignant Lymphoma: Maximizing the Basic-Translational Interface for Clinical Application; 2022 Jun 23-26; Boston, MA. Philadelphia (PA): AACR; Blood Cancer Discov 2022;3(5_Suppl):Abstract nr A22.
Association of Rapid Response Teams With Hospital Mortality in Medicare Patients
Authors: Girotra Saket , Jones Philip G. , Peberdy Mary Ann , Vaughan-Sarrazin Mary S. , Chan Paul S. , Girotra Saket , Peberdy Mary Ann , Chan Paul , Grossestreuer Anne , Moskowitz Ari , Edelson Dana , Ornato Joseph , Churpek Matthew , Kurz Michael , Starks Monique Anderson , Perman Sarah , Goldberger Zachary 
Published: September 2022

Background:
Although rapid response teams have been widely promoted as a strategy to reduce unexpected hospital deaths, most studies of rapid response teams have not adjusted for secular trends in mortality before their implementation. We examined whether implementation of a rapid response team was associated with a reduction in hospital mortality after accounting for preimplementation mortality trends.

Methods:
Among 56 hospitals in Get With The Guidelines-Resuscitation linked to Medicare, we calculated the annual rates of case mix–adjusted mortality for each hospital during 2000 to 2014. We constructed a hierarchical log-binomial regression model of mortality over time (calendar-year), incorporating terms to capture the effect of rapid response teams, to determine whether implementation of rapid response teams was associated with reduction in hospital mortality that was larger than expected based on preimplementation trends, while adjusting for hospital case mix index.

Results:

The median annual number of Medicare admissions was 5214 (range, 408–18 398). The median duration of preimplementation and postimplementation period was 7.6 years (≈2.5 million admissions) and 7.2 years (≈2.6 million admissions), respectively. Hospital mortality was decreasing by 2.7% annually during the preimplementation period. Implementation of rapid response teams was not associated with a change in mortality during the initial year (relative risk for model intercept, 0.98 [95% CI, 0.94–1.02];
P
=0.30) or in the mortality trend (relative risk for model slope, 1.01 per year [95% CI, 0.99–1.02];
P
=0.30). Among individual hospitals, implementation of a rapid response team was associated with a lower-than-expected mortality at only 4 (7.1%) and higher-than-expected mortality at 2 (3.7%) hospitals.

Conclusions:
Among a large and diverse sample of US hospitals, we did not find implementation of rapid response teams to be associated with reduction in hospital mortality. Studies are needed to understand best practices for rapid response team implementation, to ensure that hospital investment in these teams improves patient outcomes.
Evaluation of cover crops for reducing Heterodera glycines populations in microplot experiments
Authors: Neupane Kamal , Yan Guiping , Plaisance Addison 
Published: September 2022

Summary
Soybean cyst nematode (SCN; Heterodera glycines) is a major yield-reducing pathogen of soybean worldwide. Microplot experiments were conducted to evaluate ten cover crops for their effects on two SCN populations (SCN103 and SCN2W) collected from North Dakota, USA, soybean fields in 2019 and 2020. Experiments were conducted in a randomised complete block design using naturally infested field soil. A susceptible soybean ‘Barnes’ and non-planted natural soil (fallow) were used as controls. Plants were grown in outdoor conditions for 75 days before soil samples were collected. SCN eggs and juveniles were extracted from the soil samples to determine final population, population reduction and suppression. Soybean had significantly greater final population densities than all the cover crops and fallow. All cover crops and fallow reduced the initial densities of both SCN populations. All the cover crops, except chickling vetch ‘Pulse’, had lower final population densities than fallow and suppressed the SCN populations throughout the experiments. Sunnhemp (cultivar not stated; CNS), oilseed radish ‘Concorde’ and ‘Control’, and daikon radish ‘Eco-Till’ significantly reduced the SCN103 population compared to fallow. Sunnhemp, alfalfa ‘Bullseye’, and daikon radish had significant population reductions of SCN2W than fallow. Sunnhemp was found to have the greatest reductions in SCN populations ranging from 55 to 86% compared to the initial densities. This study demonstrated cover crop species/cultivars with the ability to reduce SCN populations in outdoor conditions, and the findings indicate that they could be utilised in infested fields to manage SCN.
Deep Data Example: Zbiva, Early Medieval Data Set for the Eastern Alps
Authors: Štular Benjamin , Belak Mateja 
Published: September 2022

Abstract
Zbiva is an open access online research data base for the archaeology of the Eastern Alps in the Early Middle Ages. The data base is the product of four decades of thoughtful digital curation and is continually evolving at the data record level. As such, it is best described by the concept of Deep Data. The authors deposited a subset of the Zbiva data base in a persistent open access repository, Zenodo. This was necessary to ensure stable reference, facilitate the reproducibility of the results, and promote data reuse in their ongoing publication efforts. The deposited data cover the period from 500 to 1000 ce and are spatially restricted to present-day Slovenia, southern Austria, and a small part of north-eastern Italy. The data set is particularly suitable for archaeological gis analyses.
Islam and Christianity in 19/20th Century South Asian Debates
Authors: Kamil Maqsood P. 
Published: September 2022

Abstract
Islam and Christianity share much in common but also much that is different. The evidence of interactions between them go right back to the origins of Islam in the seventh century. In early Muslim traditions, Jesus was largely presented as an ascetic, whereas their prophet Muhammad was presented as a political and military ruler; Christianity as a quietist faith and Islam as conquering faith-polity. These early traditions possibly informed the rather oppositional South Asian debates of the nineteenth century. We know that the Muslim conceptions of Jesus have been changing over time. To what extent has the image of Muhammad among Christians changed over time is also a relevant question. Muhammad and Christ were unquestionably often the focal points of the Christian Muslim debates in the nineteenth and the early twentieth century South Asia. Preliminary enquiry of sources suggest that Christians largely looked at Christ and Muhammad as fundamentally opposing characters belonging to different domains; their Muslim counterparts attempted to argue that Muhammad and Christ had much in common and, that Muhammad was in fact the very fulfilment of Christ’s own prophecy. This paper digs both into Muslim (religious doctors) and Christian (missionaries/converts) sources: i. to bring to light a new context of debates (South Asia) on Christ and Muhammad; ii. To examine how Jesus and Muhammad were portrayed in these debates and; iii. To what extent, this South Asian evidence on how Jesus and Muhammad are seen aligns with what we know from writings about them from the Middle Eastern context?