bluuebunny/crossref_metadata_2025_split huggingface dataset:
Xiaotansanjiefang inhibits the viability of colorectal cancer cells via Jagged 1/Notch 3/Snail signaling pathway
Authors: Ye Min , Du Jiaqi , Wang Xiaowei , Xiu Lijuan , Liu Xuan , Gu Yufang , Pei Bei , Sun Dazhi , Yue Xiaoqiang 
Published: August 2022

AbstractThe purpose of this study is to explore the anti‐colorectal cancer of Xiaotansanjiefang, a famous traditional Chinese medicine, and its potential anti‐cancer mechanism. In this study, the HCT116 cell spheres were prepared as in vitro study model. We found the Xiaotansanjiefang medication was able to inhibit the proliferation of HCT116 cell spheres in a dose‐dependent manner, especially in 3 and 6 mg/ml Xiaotansanjiefang medication treated groups. We also found the high concentration of Xiaotansanjiefang medication could suppress the migration and promote the apoptosis of HCT116 cell spheres. Moreover, we found the expression of Jagged 1, Notch 3, Snail, and Hes 1 were decreased in HCT116 cell spheres treated with Xiaotansanjiefang medication. Furthermore, the proliferation and apoptosis behaviors of HCT116 cell spheres treated with Xiaotansanjiefang medication were reversed with the addition of Jagged 1 Fc chimera protein. The expression of Jagged 1, Notch 3, Snail, and Hes 1 were also increased again in HCT116 cells treated with Xiaotansanjiefang medication plus with Jagged 1 Fc chimera protein. The presented study may provide a promising strategy to treat and prevent colorectal cancer.
A Sonic Net deters European starlings Sturnus vulgaris from maize silage stores
Authors: Woods Richard D. , Swaddle John P. , Bearhop Stuart , Colhoun Kendrew , Gaze William H. , Kay Suzanne M. , McDonald Robbie A. 
Published: August 2022

AbstractDeterrents against avian pest species might be more effective if they were based on some aspect of the target species' sensory salience. Sonic Nets broadcast a loud and spatially‐ focused pink noise that spans the frequency range of the target species' vocalizations, restricting interspecific communication so that it is costly for birds to remain in the treated area. In parts of their native and introduced ranges, European starlings (Sturnus vulgaris) impact livestock operations where they consume and contaminate animal feed, damage infrastructure, and may contribute to pathogen transmission. We evaluated Sonic Net technology to exclude starlings from outdoor maize silage stores on 10 dairy farms in Cornwall, U.K. in February–March and November–December 2019. We quantified frequency of starling presence and approximate flock size and combined these to estimate starling burden in starling‐minutes before, during, and after Sonic Net treatment. During an initial proof‐of‐concept trial, each phase lasted 2 days, whilst in a second, longer experiment, treatment lasted 14 days. During Sonic Net treatment, frequency of starling presence was reduced, flock sizes were smaller, and starling‐minutes were reduced by 94% and 89% in the 2‐day and 14‐day treatments, respectively. In the last 2 days of the 14‐day treatment, starling‐minutes remained 85% lower than before treatment, but 4 of 10 farms experienced some diminution of effects after 6 days. Sonic Nets had a significant and sustained effect, with potential for deterring avian pests from agricultural and other settings.
Assessment of irreversibility optimization in Casson nanofluid flow with leading edge accretion or ablation
Authors: Khan Noor Saeed , Humphries Usa Wannasingha , Kumam Wiyada , Kumam Poom , Muhammad Taseer 
Published: August 2022

AbstractEntropy generation in unsteady magneto‐bioconvection Casson nanofluid flow with gyrotactic microorganisms in the presence of Cattaneo–Christov heat and mass flux theory is analyzed. Buongiorno nanofluid model is followed taken into account the influences of viscous dissipation, Brownian motion, and thermophoresis. Mathematica is used to compute the transformed equations through homotopy analysis method (HAM) resulting from the implementation of similarity transformations on governing equations and boundary conditions. The effects of pertinent parameters on different profiles are shown in graphs and discussed in detail.
Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo
Authors: Paoletti Camilla , Divieto Carla , Chiono Valeria 
Published: August 2022

AbstractDirect reprogramming of fibroblasts into induced cardiomyocytes (iCMs) through microRNAs (miRNAs) is a new emerging strategy for myocardial regeneration after ischemic heart disease. Previous studies have reported that murine fibroblasts can be directly reprogrammed into iCMs by transient transfection with four miRNAs (miRs-1, 133, 208 and 499 – termed “miRcombo”). While advancement in the knowledge of direct cell reprogramming molecular mechanism is in progress, it is important to investigate if this strategy may be translated to humans. Recently, we demonstrated that miRcombo transfection is able to induce direct reprogramming of adult human cardiac fibroblasts (AHCFs) into iCMs. Although additional studies are needed to achieve iCM maturation, our early findings pave the way toward new therapeutic strategies for cardiac regeneration in humans. This chapter describes methods for inducing direct reprogramming of AHCFs into iCMs through miRcombo transient transfection, showing experiments to perform for assessing iCM generation.
Adapting a Faceted Search Task Model for the Development of a Domain-Specific Council Information Search Engine
Authors: Schoegje Thomas , de Vries Arjen , Pieters Toine 
Published: August 2022

AbstractDomain specialists such as council members may benefit from specialised search functionality, but it is unclear how to formalise the search requirements when developing a search system. We adapt a faceted task model for the purpose of characterising the tasks of a target user group. We first identify which task facets council members use to describe their tasks, then characterise council member tasks based on those facets. Finally, we discuss the design implications of these tasks for the development of a search engine.Based on two studies at the same municipality we identified a set of task facets and used these to characterise the tasks of council members. By coding how council members describe their tasks we identified five task facets: the task objective, topic aspect, information source, retrieval unit, and task specificity. We then performed a third study at a second municipality where we found our results were consistent.We then discuss design implications of these tasks because the task model has implications for 1) how information should be modelled, and 2) how information can be presented in context, and it provides implicit suggestions for 3) how users want to interact with information.Our work is a step towards better understanding the search requirements of target user groups within an organisation. A task model enables organisations developing search systems to better prioritise where they should invest in new technology.
Low-risk polycythemia vera treated with phlebotomies: clinical characteristics, hematologic control and complications in 453 patients from the Spanish Registry of Polycythemia Vera
Authors: Triguero Ana , Pedraza Alexandra , Pérez-Encinas Manuel , Mata-Vázquez María Isabel , Vélez Patricia , Fox Laura , Gómez-Calafat Montse , García-Delgado Regina , Gasior Mercedes , Ferrer-Marín Francisca , García-Gutiérrez Valentín , Angona Anna , Gómez-Casares María Teresa , Cuevas Beatriz , Martínez Clara , Pérez Raúl , Raya José María , Guerrero Lucía , Murillo Ilda , Bellosillo Beatriz , Hernández-Boluda Juan Carlos , Sanz Cristina , Álvarez-Larrán Alberto ,   On behalf of the MPN Spanish Group (GEMFIN)
Published: August 2022

AbstractHematological control, incidence of complications, and need for cytoreduction were studied in 453 patients with low-risk polycythemia vera (PV) treated with phlebotomies alone. Median hematocrit value decreased from 54% at diagnosis to 45% at 12 months, and adequate hematocrit control over time (< 45%) was observed in 36%, 44%, and 32% of the patients at 6, 12, and 24 months, respectively. More than 5 phlebotomies per year in the maintenance phase were required in 19% of patients. Worsening thrombocytosis, age > 60 years, and microvascular symptoms constituted the main indications for starting cytoreduction. Median duration without initiating cytoreduction was significantly longer in patients younger than 50 years (< 0.0001). The incidence rate of thrombosis under phlebotomies alone was 0.8% per year and the estimated probability of thrombosis at 10 years was 8.5%. The probability of arterial thrombosis was significantly higher in patients with arterial hypertension whereas there was a trend to higher risk of venous thrombosis in cases with high JAK2V617F allele burden. Rates of major bleeding and second primary neoplasm were low. With a median follow-up of 9 years, survival probability at 10 years was 97%, whereas the probability of myelofibrosis at 10 and 20 years was 7% and 20%, respectively. Progression to acute myeloid leukemia was documented in 3 cases (1%). Current management of low-risk PV patients is associated with low rate of thrombosis and long survival. New treatment strategies are needed for improving hematological control and, in the long term, reducing progression to myelofibrosis.
Martensitic Stainless Steels for Food Contact Applications
Authors: Zunko Horst , Turk Christoph 
Published: August 2022

AbstractFor industrial mechanical food processing steps, like cutting, slicing, grating, passing or similar applications, tools of martensitic stainless steels are used preferably because of their high hardness and corrosion resistance. The latter is decisive to avoid contamination of foodstuff by elements transferred from the steel alloy into the processed food. In this contribution various martensitic stainless steels in different heat treatment conditions were investigated regarding their metal release behavior in food simulants. Therefore, migrations tests were carried out according to the guideline of the Council of Europe. During the examination, the specific migration of elements was determined and compared to defined release limits, which take into account the different toxicity for the human body. The results allow an assessment of the suitability of the tested grades and heat treatment conditions as contact material for different types of food.
Regelungstechnische Konzepte zur Messbereichserweiterung kalorimetrischer Strömungssensoren
Authors: Cerimovic Samir , Beigelbeck Roman , Kohl Franz , Sauter Thilo , Keplinger Franz 
Published: August 2022

ZusammenfassungKalorimetrische Strömungssensoren sind eine sehr verbreitete Art von thermischen Strömungssensoren. Sie werten eine strömungsbedingte Verzerrung des Temperaturfeldes um eine Wärmequelle aus. Im einfachsten Betriebsfall mit konstanter Heizleistung weisen sie eine ausgezeichnete Sensitivität auf. Allerdings ist das Ausgangssignal keine monotone Funktion der Strömungsgeschwindigkeit, sodass der nutzbare Messbereich aufgrund der Mehrdeutigkeit der Kennlinie stark eingegrenzt ist. Für einen breiten Einsatz muss mit steigender Strömungsgeschwindigkeit die Heizleistung mit einem Regler nachgeführt werden. Dabei kommen verschiedene regelungstechnische Konzepte zur Anwendung, die anhand zweier konkreter Sensorausführungen näher erläutert werden.
The course of swallowing problems in the first 2 years after diagnosis of head and neck cancer
Authors: Vermaire Jorine A. , Raaijmakers Cornelis P. J. , Monninkhof Evelyn M. , Leemans C. René , Baatenburg de Jong Robert J. , Takes Robert P. , Leeuw Irma M. Verdonck-de , Jansen Femke , Langendijk Johannes A. , Terhaard Chris H. J. , Speksnijder Caroline M. 
Published: August 2022

Abstract
Introduction
Head and neck cancer (HNC) and its treatment often negatively impact swallowing function. The aim was to investigate the course of patient-reported swallowing problems from diagnosis to 3, 6, 12, and 24 months after treatment, in relation to demographic, clinical, and lifestyle factors.

Methods
Data were used of the Netherlands Quality of Life and Biomedical Cohort Study in head and neck cancer research (NET-QUBIC). The primary outcome measures were the subscales of the Swallowing Quality of Life Questionnaire (SWAL-QOL). Linear mixed-effects models (LMM) were conducted to investigate changes over time and associations with patient, clinical, and lifestyle parameters as assessed at baseline.

Results
Data were available of 603 patients. There was a significant change over time on all subscales. Before treatment, 53% of patients reported swallowing problems. This number increased to 70% at M3 and decreased to 59% at M6, 50% at M12, and 48% at M24. Swallowing problems (i.e., longer eating duration) were more pronounced in the case of female, current smoking, weight loss prior to treatment, and stage III or IV tumor, and were more prevalent at 3 to 6 months after treatment. Especially patients with an oropharynx and oral cavity tumor, and patients receiving (C)RT following surgery or CRT only showed a longer eating duration after treatment, which did not return to baseline levels.

Conclusion
Half of the patients with HNC report swallowing problems before treatment. Eating duration was associated with sex, smoking, weight loss, tumor site and stage, and treatment modality, and was more pronounced 3 to 6 months after treatment.
Evaluation of energy extraction of PV systems affected by environmental factors under real outdoor conditions
Authors: Hassan Muhammed A. , Bailek Nadjem , Bouchouicha Kada , Ibrahim Abdelhameed , Jamil Basharat , Kuriqi Alban , Nwokolo Samuel Chukwujindu , El-kenawy El-Sayed M. 
Published: August 2022

Abstract
The global agenda to increase the renewable energy share has driven many countries and entities to harness solar energy from solar photovoltaic (PV) systems. However, the power generation of PV systems is strongly affected by climate conditions. Therefore, the main objective of this study is to analyze and predict the power generation of different PV technologies under arid desert climate conditions on an hourly basis. Two areas have been considered as case studies: Adrar in Algeria and Alice Springs in Australia. A total of nine physical models and input parameter combinations from six different power plants have been used and tested for the suitability of the proposed models for predicting the power yield of PV power plants depending on solar irradiance and other meteorological variables. Then, an ensemble learning technique is applied to improve the performance capabilities of the best-fit input combinations. The results reveal that the global irradiance, ambient air temperature, and relative humidity combination are the most related to the PV power output of all technologies under all-sky conditions and provide effective and efficient performance with the proposed ensemble learning, with an estimated accuracy of over 99%.
Entwicklung einer thorakoabdominellen Hybridprothese – vom Konzept zur Erstimplantation
Authors: Wipper Sabine , Kölbel Tilo , Enzmann Florian , Debus Eike Sebastian 
Published: August 2022

Zusammenfassung
Hintergrund
Die Therapie thorakoabdomineller Aortenpathologien ist nach wie vor eine Herausforderung, sowohl endovaskulär als auch offen-chirurgisch.

Fragestellung
Ziel war die Entwicklung einer Hybridprothese zur Versorgung der thorakoabdominellen Aorta ohne Thorakotomie, thorakale Artenklemmung und Herz-Lungen-Maschine (HLM).

Material und Methode
Nach Testung am Modell wurde die Implantationstechnik und Handhabung der neuen Hybridprothese in-vivo im Großtiermodell nach standardisiertem Protokoll evaluiert. Auch Operationsdauer, Hämodynamik und Organperfusion inklusive spinaler Perfusion wurden mittels Fluoreszenzmikrosphärentechnik untersucht. Die Ergebnisse wurden mit einer konventionellen offen-chirurgischen Versorgung verglichen. Bildgebende Erfolgskontrollen erfolgten mittels Angiographie und postmortaler CT-Angiographie. Basierend auf den Ergebnissen erfolgte die Modifikation des Prototyps und der Operationstechnik, bevor die erste Implantation am Patienten erfolgte.

Ergebnisse
Im Rahmen der In-vivo-Evaluation wurde der Graft in mehreren Schritten modifiziert, um die Implantationstechnik möglichst einfach und sicher zu gestalten. Das finale Design der neu entwickelten Thoracoflo®-Hybridprothese (Terumo Aortic, Vascutek Ltd. Scotland, UK) beinhaltet einen proximalen Stentgraft, der über eine Halsmanschette mit einer 7‑fach gebranchten abdominellen Dacron-Prothese verbunden ist. Die retrograde viszerale Perfusion über eine temporär angelegte End-zu-Seit-Anastomose eines Iliakalschenkels mit einer Iliakalarterie nach Implantation des thorakalen Stentgraft-Anteils (SPIDER-Technik) ermöglicht eine Operation ohne Thorakotomie und HLM. Die Thoracoflo®-Hybridprothese konnte erfolgreich an einer selektionierten Patientin implantiert werden.

Schlussfolgerung
Nach ausführlicher In-vitro- und In-vivo-Testung konnte ein neues Hybridverfahren mit der Thoracoflo®-Hybridprothese entwickelt werden, das bereits erfolgreich an einer Patientin eingesetzt wurde.
Usefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome
Authors: Saito Rika , Kawamoto Yasuyuki , Nishida Mutsumi , Iwai Takahito , Kikuchi Yasuka , Yokota Isao , Takagi Ryo , Yamamura Takahiro , Ito Ken , Harada Kazuaki , Yuki Satoshi , Komatsu Yoshito , Sakamoto Naoya 
Published: August 2022

Abstract
Background
Sinusoidal obstruction syndrome (SOS) refers to liver injury caused by hematopoietic stem cell transplantation (HSCT) and anticancer drugs including oxaliplatin. Increased splenic volume (SV) on computed tomography (CT) indicates oxaliplatin-induced SOS. Similarly, ultrasonography and liver stiffness measurement (LSM) by shear-wave elastography (SWE) can help diagnose SOS after HSCT; however, their usefulness for diagnosing oxaliplatin-induced SOS remains unclear. We investigated the usefulness of the Hokkaido ultrasonography-based scoring system with 10 ultrasonographic parameters (HokUS-10) and SWE in diagnosing oxaliplatin-induced SOS early.

Methods
In this prospective observational study, ultrasonography and SWE were performed before and at 2, 4, and 6 months after oxaliplatin-based chemotherapy. HokUS-10 was used for assessment. CT volumetry of the SV was performed in clinical practice, and an SV increase ≥ 30% was considered the diagnostic indicator of oxaliplatin-induced SOS. We assessed whether HokUS-10 and SWE can lead to an early detection of oxaliplatin-induced SOS before an increased SV on CT.

Results
Of the 30 enrolled patients with gastrointestinal cancers, 12 (40.0%) with an SV increase  ≥ 30% on CT were diagnosed with SOS. The HokUS-10 score was not correlated with an SV increase ≥ 30% (r = 0.18). The change in rate of three HokUS-10 parameters were correlated with an SV increase ≥ 30% (r = 0.32–0.41). The change in rate of LSM by SWE was correlated with an SV increase  ≥ 30% (r = 0.40).

Conclusions
The usefulness of HokUS-10 score was not demonstrated; however, some HokUS-10 parameters and SWE could be useful for the early diagnosis of oxaliplatin-induced SOS.
Automated Protocoling for MRI Exams—Challenges and Solutions
Authors: Denck Jonas , Haas Oliver , Guehring Jens , Maier Andreas , Rothgang Eva 
Published: August 2022

AbstractAutomated protocoling for MRI examinations is an amendable target for workflow automation with artificial intelligence. However, there are still challenges to overcome for a successful and robust approach. These challenges are outlined and analyzed in this work. Through a literature review, we analyzed limitations of currently published approaches for automated protocoling. Then, we assessed these limitations quantitatively based on data from a private radiology practice. For this, we assessed the information content provided by the clinical indication by computing the overlap coefficients for the sets of ICD-10-coded admitting diagnoses of different MRI protocols. Additionally, we assessed the heterogeneity of protocol trees from three different MRI scanners based on the overlap coefficient, on MRI protocol and sequence level. Additionally, we applied sequence name standardization to demonstrate its effect on the heterogeneity assessment, i.e., the overlap coefficient, of different protocol trees. The overlap coefficient for the set of ICD-10-coded admitting diagnoses for different protocols ranges from 0.14 to 0.56 for brain/head MRI exams and 0.04 to 0.57 for spine exams. The overlap coefficient across the set of sequences used at two different scanners increases when applying sequence name standardization (from 0.81/0.86 to 0.93). Automated protocoling for MRI examinations has the potential to reduce the workload for radiologists. However, an automated protocoling approach cannot be solely based on admitting diagnosis as it does not provide sufficient information. Moreover, sequence name standardization increases the overlap coefficient across the set of sequences used at different scanners and therefore facilitates transfer learning.
Soil carbon sequestration as a climate strategy: what do farmers think?
Authors: Buck Holly Jean , Palumbo-Compton Alexis 
Published: August 2022

AbstractCountries and companies with net-zero emissions targets are considering carbon removal strategies to compensate for remaining greenhouse gas emissions. Soil carbon sequestration is one such carbon removal strategy, and policy and corporate interest is growing in figuring out how to motivate farmers to sequester more carbon. But how do farmers in various cultural and geographic contexts view soil carbon sequestration as a climate mitigation or carbon removal strategy? This article systematically reviews the empirical social science literature on farmer adoption of soil carbon sequestration practices and participation in carbon markets or programs. The article finds thirty-seven studies over the past decade that involve empirical research with soil carbon sequestering practices in a climate context, with just over a quarter of those focusing on the Global South. A central finding is co-benefits are a strong motivator for adoption, especially given minimal carbon policies and low carbon prices. Other themes in the literature include educational and cultural barriers to adoption, the difference between developing and developed world contexts, and policy preferences among farmers for soil carbon sequestration incentives. However, we argue that given the rising profile of technical potentials and carbon credits, this peer-reviewed literature on the social aspects of scaling soil carbon sequestration is quite limited. We discuss why the social science literature is so small, and what this research gap means for efforts to achieve higher levels of soil carbon sequestration. We conclude with a ten-point social science research agenda for social science on soil carbon—and some cautions about centering carbon too strongly in research and policy.