bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissecting the In Vitro Efficacy of Octreotide and Cabergoline in GH- and GH/PRL-Secreting Pituitary Tumors
Authors: Gatto Federico , Feelders Richard A , van Koetsveld Peter M , Dogan Fadime , Neggers Sebastian J C M M , van der Lelij Aart-Jan , Amarù Jessica , Ferone Diego , Hofland Leo J 
Published: November 2022

AbstractContextCabergoline (CAB) is an off-label medical therapy for acromegaly, overshadowed by first-generation somatostatin receptor ligands, eg, octreotide (OCT).ObjectiveThis was a head-to-head comparison between OCT and CAB in inhibiting growth hormone (GH) secretion in primary cultures of GH- and GH/prolactin (PRL)-secreting tumors; we also investigated the role of somatostatin (SST) and dopamine type 2 (D2R) receptor expression.MethodsWe evaluated the antisecretory effect of OCT and CAB, together with receptor mRNA expression, in 23 tumor cultures obtained from acromegaly patients referred to the Erasmus Medical Center (Rotterdam, The Netherlands). GH concentrations in cell culture media were determined after 72-hour OCT and CAB treatment (10 nM).ResultsOCT showed a slightly higher efficacy compared with CAB (GH decrease −39.5% vs −32.5%, P = 0.079). The effect of the 2 drugs was superimposable in GH/PRL co-secreting tumors (−42.1% vs −44.8%), where SST1 and D2R had a higher expression compared with the pure GH-secreting tumors (P = 0.020 and P = 0.026). OCT was more effective than CAB in 8/23 cultures, while CAB was more effective than OCT in 3/23 (CAB+ group). In CAB+ tumors, SST1 expression was higher compared with the other groups (P = 0.034). At receiver operating characteristic (ROC) curve analysis, SST1 and D2R discriminated between GH and GH/PRL co-secretion (AUC 0.856, P = 0.013; AUC 0.822, P = 0.024). SST1 was the best predictor of CAB response (≥50% GH reduction, AUC 0.913, P = 0.006; 80% sensitivity, 94% specificity).ConclusionOCT is 5% to 10% more effective than CAB in vitro. SST1 mRNA expression can represent a reliable marker of GH/PRL co-secreting tumors showing a preferential response to CAB treatment.
France's Great Indian Misadventure
Authors: Margerison Kenneth 
Published: November 2022

AbstractThe French interest in attacking the British in India during the American Revolution was promoted by a variety of individuals with experience and often personal interests on the subcontinent. These individuals convinced the naval minister, Antoine de Sartine, and his successor, Charles de la Croix, marquis de Castries, that the Indian princes were eager to liberate India from British tyranny and with French assistance would launch an uprising to achieve this goal. Both ministers became avid proponents of launching an attack on the British in India coinciding with French entrance into the American War. Initially opposed to this venture, the foreign minister, Charles Gravier, comte de Vergennes, ultimately came to see its value. The exaggerated predictions of a massive Indian revolt against the British never materialized. The difficulties of mounting a long-distance invasion and the tardy arrival of General Charles Joseph Patissier, marquis de Bussy-Castelnau, who did not reach India until after peace negotiations had begun, resulted in the failure of the French intervention.L'intérêt des Français à attaquer les Britanniques en Inde pendant la Révolution américaine a été promu par une variété de personnes ayant de l'expérience et souvent des intérêts personnels sur le sous-continent. Ces individus ont convaincu le ministre de la Marine Sartine et son successeur Castries que les princes indiens désiraient libérer l'Inde de la tyrannie britannique et, avec l'aide de la France, lanceraient un soulèvement pour atteindre cet objectif. Les deux ministres devinrent de fervents partisans du lancement d'une attaque contre les Britanniques en Inde coïncidant avec l'entrée de la France dans la guerre américaine. Initialement opposé à cette entreprise, le ministre des Affaires étrangères Vergennes finit par en reconnaître la valeur. Les prédictions exagérées d'une révolte indienne massive contre les Britanniques ne se sont jamais matérialisées. Les difficultés d'organiser une invasion à longue distance et l'arrivée tardive de Bussy, qui n'arriva en Inde qu'après le début des négociations de paix, entraînèrent l’échec de l'intervention française.
Less Is More? Repartnering and Completed Cohort Fertility in Finland
Authors: Andersson Linus , Jalovaara Marika , Uggla Caroline , Saarela Jan 
Published: November 2022

Abstract
An extensive literature theorizes the role of repartnering for cohort fertility and whether union dissolution can be an engine for fertility. A large share of higher order unions are nonmarital cohabitations, but most previous studies on completed cohort fertility have analyzed only marital unions, and none have incorporated nonmarital cohabitations using population-level data. To analyze the relationship between the number of unions and cohort fertility for men and women, we use Poisson regression with Finnish register data to enumerate every birth, marriage, and cohabitation among the 1969–1972 birth cohorts at ages 18–46. We show that dissolutions of first cohabitations are the main pathway to repartnering and that most higher order unions are cohabitations. Nonmarital repartnering is a strong predictor of low fertility. In contrast, remarriage is positively associated with cohort fertility. Because the bulk of first-union dissolutions and higher order unions are nonmarital, repartnering is not an efficient engine for fertility at the aggregate level. Marriage and cohabitation are far from indistinguishable in a country often described as a second demographic transition forerunner.
Respiratory and diarrhoeal pathogens in Malawian children hospitalised with diarrhoea and association with short-term growth: A prospective cohort study
Authors: Chisala Mphatso , Nyangulu Wongani , Nyirenda James , Iroh Tam Pui-Ying 
Published: November 2022

Background: Pneumonia and diarrhoea are the leading causes of childhood mortality and morbidity worldwide. The gut-lung axis is associated with disease, and these common infections, especially the parasite Cryptosporidium, are associated with malnutrition. We sought to evaluate the association of respiratory and gastrointestinal (GI) pathogens with short-term growth among children hospitalised with diarrhoeal disease. Methods: In this sub-study, we followed 27 children (two-24 months) who tested positive for Cryptosporidium spp. for eight weeks with two weekly sampling of the respiratory and GI tract. Respiratory and stool pathogens were detected using quantitative molecular methods. Nutritional outcomes were assessed as length-for-age (LAZ), weight-for-length (WLZ) and weight-for-age (WAZ) z-scores. Changes over the study period were compared using repeated analysis of variance and mixed effects model analysis. Results: In this period,104 sputum and stool samples were collected. All stool samples had at least one pathogen detected, with an average of 5.1 (SD 2.1) stool pathogens, compared to 84% of the sputum samples with an average 3.5 (SD 1.8). Diarrhoeagenic E. coli were the most common stool pathogens (89%), followed by Cryptosporidium (57.6%) and Adenovirus pan (41%). In sputum, Streptococcus pneumoniae was the most prevalent pathogen (84%), followed by hinovirus (56%) and Moraxella catarrhalis (50%). There was a significant change in WAZ over the follow-up period. Children who had ≥3 GI pathogens had significantly a lower LAZ mean score at enrolment (-1.8 [SD 1.4]) and across the follow-up period. No relationship between respiratory pathogens and short-term growth was observed. Out of 49 sputum samples that had ≥3 pathogens, 42 (85%) concurrent stool samples had ≥3 GI pathogens. Conclusions: Among young children hospitalised with diarrhoea, multiple GI and respiratory pathogens were prevalent over an eight-week follow-up period. The presence of more GI, but not respiratory, pathogens was significantly associated with reduced short-term growth.
SOCIAL JUSTICE IN THE CONTEXT OF EPISTEMOLOGICAL URBANISM
Authors: Kozlova Yulia V. 
Published: November 2022

The purpose of this work is to substantiate the study of the modern city as a system, to determine the main directions of the study of the social processes of the city in the categorical and methodological scheme of epistemology. The rationale for the relevance of this approach is the increasing social differentiation in cities, the polarization of local communities. The city, as a key form of the social system in its subject and communicative space, creates objects and processes for citizens, but does not always give the opportunity to participate in this creation and express their attitude to it. Scientific production aimed at obtaining new reliable knowledge about the urban system, focused on the knowledge of social processes and phenomena, as well as the study of this knowledge itself, is the resource that would improve the quality of life of citizens and optimize their interaction with municipal structures, change their civic position.
Research methods used in the work: comparatively-historical, phenomenological, structural, functional, as well as systematic approach.
The results of the work are to determine those cognitive categories (problem, theory, fact, method) on which it is necessary to build a productive and reliable urban research, to identify the role of knowledge in the construction of urban phenomena, to characterize the “resistance of the studied object”. The results of the study can be used both in the development of individual phenomenological aspects of urban sociology and for urban design
SOCIO-CULTURAL FACTORS OF THE DEVELOPMENT OF CHECHEN PAINTING IN THE 1960S-80S
Authors: Khamzatova Zarema R. 
Published: November 2022

Socio-cultural factors played a considerable role in the formation of Chechen pictorial art of the 1960s-80s. Its formation and development began with the people’s return from displacement and the restoration of statehood in 1957, which prompted an upsurge in all spheres of activity. The idea of socio-cultural imperative in conveying the existential experience of the artist-creator through artistic images is substantiated. Particular attention is paid to the national idea as a leading factor in the formation of statehood, the development of society and its humanitarian sphere.
Methods of axiological, culturological, structural and functional analysis allowed us to draw conclusions about the compliance of paintings with the basic, objectively determined principles of reflecting objective reality in artistic form.
It has been established that the paintings of Chechen painters contain a complex of various emotional and personal impressions and, at the same time, objectively determined principles of human social life.
FUNCTIONAL AND PERSONALIZED NUTRITION AS NEW GASTRONOMIC DIRECTIONS
Authors: Ermolaev Vladimir A. 
Published: November 2022

In the article, the author examines two relatively new gastronomic trends, such as functional and personalized types of nutrition. As follows from the names, the directions pursue the goals of ensuring the functioning (of the organism) and compliance with the lifestyle (of a person).
Considering functional nutrition (AF), it should be noted that, aimed primarily at ensuring, first of all, the vital activity of the body as a whole, this direction leads to the need to use specific products and follow certain traditions. Despite the fact that such a nutrition strategy has come to the fore today, it is not something new, since even in Soviet times the foundations of functional nutrition were laid in the form of rationalization of food consumption by the population through a network of state catering establishments.
The introduced culture of consumption, with varying success, became a symbol of the Soviet era, which, of course, was influenced by the government of the USSR with its ideology of a perfectly functioning organism of the working man, the sufficiency of nutrition in the Soviet Union and the rejection of home cooking as a “hotbed of the bourgeoisie”.
Meanwhile, today the FP once again occupies a leading position among the tools and means of a healthy lifestyle, but without political and ideological background.
However, functional nutrition, as a rule, does not take into account individual characteristics of a person. As an example of such a diet and, in general, a culture of consumption (with a certain time and place), organized meals in kindergartens and schools can be cited.
Thus, there is a need for individual accounting of the sufficiency (or insufficiency) of the volume of food components consumed. This is personalized nutrition, which takes into account a person’s lifestyle, that is, nutrition recommendations are based on his genetic inheritance, anamnesis, energy consumption, gender, activity level, daily activity characteristics, etc.
Individualized nutrition creates prerequisites for the development of various technologies in the food industry, digital technologies, etc.
The author believes that it is expedient and fair to single out the third gastronomic direction – functionally personalized nutrition, which takes into account both components at once. In this regard, at the same time, nutritionology is developing as a science and a type of practical activity related to the organization of functionally personalized human nutrition. In addition, the growth of the need for this strategy will lead to a change in the structure of the offer in the field of gastronomy, forms of everyday life associated with food consumption.
“SE UMA DOG PODE APRENDER LIBRAS, VOCÊS TAMBÉM PODEM!” SÉRIO?! / “If a dog can learn Libras, you can too!” Really?!
Authors: Da Silva Rogério Toscano , Buscácio Livia Letícia Belmiro 
Published: November 2022

O presente trabalho, baseado na Análise do discurso (PÊCHEUX, 2009 [1988], 2014 [1990]; ORLANDI, 1984, 2008a, 2008b, 2015b) e na História das Ideias Linguísticas (AUROUX,1992, 1998; ORLANDI, 2008b), constitui-se de um gesto de análise de dizeres sobre aprender e ensinar Língua Brasileira de Sinais inscritos em materiais de divulgação de cursos nas redes sociais. O objeto nele abordado encontra-se no campo das tensões entre os discursos sobre 1) o ensino de Libras e a posição surdo e posição ouvinte no lugar de aprendiz; 2) a Libras sendo significada como língua e/ou linguagem, em um retesamento com a língua oficial brasileira, designada por Língua portuguesa; e 3) os lugares de “autoridade” para ensinar /aprender Libras; 4) as ideias e saberes linguísticos (AUROUX,1992) materializados no dizer do lugar da influencer surda. Verificou-se também o funcionamento do discurso digital, conforme Dias (2018). O gesto analítico chegou, por meio da paráfrase (ORLANDI, 2015a), a averiguar a circulação de saberes e ideias linguísticas sobre as línguas de sinais e sua aprendizagem. Com isso, visamos contribuir para o campo de modo a produzir deslocamentos de saberes e formas de ensinar Libras, considerando um confronto entre-línguas do/no Brasil que reverbera na relação entre língua, sujeito e ensino.
LÍNGUAS DE SINAIS: TRAVESSIAS LINGUÍSTICAS, LITERÁRIAS E ARTÍSTICAS / SIGN LANGUAGES: LINGUISTIC, LITERARY AND ARTISTIC CROSSINGS
Authors: Barros Adriana Lúcia De Escobar Chaves de , Ramos Danielle Cristina Mendes Pereira , Muniz Valéria Campos 
Published: November 2022

Apresentação do Dossiê 25 - LÍNGUAS DE SINAIS: TRAVESSIAS LINGUÍSTICAS, LITERÁRIAS E ARTÍSTICAS / SIGN LANGUAGES: LINGUISTIC, LITERARY AND ARTISTIC CROSSINGS
Evaluation of bladder dysfunction in children and adolescents with type 1 diabetes mellitus by uroflowmetry
Authors: Onder Camas Asan , Özel Şeyhmus Kerem , Kocabey Sütçü Zümrüt , Hepokur Merve , Emeksiz Hamdi Cihan 
Published: November 2022

AbstractObjectivesDiabetic cystopathy is a condition characterized by decreased bladder sensitivity, increased bladder capacity, decreased bladder contractility and increased residual urine volume. It can also be considered as an early indicator of autonomic dysfunction. In this study, it was aimed to evaluate bladder functions by uroflowmetry in children and adolescents with the diagnosis of type 1 diabetes mellitus.MethodsType 1 diabetes mellitus children and adolescents were applied uroflowmetry and post-void residual urine volumes were evaluated. The physical examination findings of the patients and the laboratory data of diabetes control were obtained from the clinic files.ResultsA total of 51 cases aged 72–216 (155.6 ± 35.4) months were enrolled into the study. Diabetes age of the cases was 66.5 ± 46.2(13–180) months. The last one year average of HbA1cof the patients was found to be 9.7 ± 1.9%. A total of 9.8% had good, 39.2% moderate and 51% poor metabolic control, respectively. While urodynamic evaluation was normal in 36 (70.6%) of 51 participants, voiding dysfunction was found in 15. There was no statistically significant difference between groups with and without voiding dysfunction in terms of age, gender, duration of diabetes, metabolic control and HbA1cvalues.ConclusionsIt is very important to follow up patients with type 1 diabetes mellitus in terms of autonomic dysfunction. Diabetic bladder clinic, which can be observed independently of diabetes duration and metabolic control, is also included in this status. Urodynamic evaluation will be helpful both in demonstrating bladder dysfunction and in preventing possible complications.
Existence and multiplicity of solutions for second-order Dirichlet problems with nonlinear impulses
Authors: Ma Mantang , Ma Ruyun 
Published: November 2022

Abstract
We are concerned with Dirichlet problems of impulsive differential equations

−

u

″

(

x

)

−
λ
u

(

x

)

+
g

(

x
,
u

(

x

)

)

+

∑

j
=
1

p

I

j

(

u

(

x

)

)

δ

(

x
−

y

j

)

=
f

(

x

)

for a.e.

x
∈

(

0
,
π

)

,

u

(

0

)

=
u

(

π

)

=
0
,

\left\{\begin{array}{l}-{u}^{^{\prime\prime} }\left(x)-\lambda u\left(x)+g\left(x,u\left(x))+\mathop{\displaystyle \sum }\limits_{j=1}^{p}{I}_{j}\left(u\left(x))\delta \left(x-{y}_{j})=f\left(x)\hspace{1em}\hspace{0.1em}\text{for a.e.}\hspace{0.1em}\hspace{0.33em}x\in \left(0,\pi ),\\ u\left(0)=u\left(\pi )=0,\\ \end{array}\right.

where

λ

\lambda

is a parameter and runs near 1,

f
∈

L

2

(

0
,
π

)

f\in {L}^{2}\left(0,\pi )

,

I

j

∈
C

(

R
,
R

)

{I}_{j}\in C\left({\mathbb{R}},{\mathbb{R}})

,

j
=
1
,
2
,

…

,
p

j=1,2,\ldots ,p

,

p
∈
N

p\in {\mathbb{N}}

, the nonlinearity

g
:

[

0
,
π

]

×
R
→
R

g:\left[0,\pi ]\times {\mathbb{R}}\to {\mathbb{R}}

satisfies the Carathéodory condition,

δ
=
δ

(

x

)

\delta =\delta \left(x)

denote the Dirac delta impulses concentrated at 0, which are applied at given points

0
<

y

1

<

y

2

<
⋯
<

y

p

<
π

0\lt {y}_{1}\lt {y}_{2}\hspace{0.33em}\lt \cdots \lt {y}_{p}\lt \pi

. We show the existence and multiplicity of solutions to the aforementioned problem for

λ

\lambda

in a neighborhood of 1 by using degree theory and bifurcation theory.
Vertrauen und Akzeptanz bei KI-basierten, industriellen Arbeitssystemen
Authors: Jung Maria , Werens Samantha , von Garrel Jörg 
Published: November 2022

Abstract
Der Einsatz von Künstlicher Intelligenz wird bisher überwiegend technologisch betrachtet. Dabei werden häufig die Sicht der Arbeitnehmer:innen und mögliche Potenziale einer humanzentrierten Gestaltung, mit der ein höherer Grad an Selbstbestimmtheit für die Mitarbeiter:innen erreicht werden kann, vernachlässigt. Um mögliche Faktoren einer mitarbeiterfreundlichen Implementierung von bzw. in verschiedene KI-Systemen zu ermitteln, ist eine qualitative Studie durchgeführt worden.
Generierung von disruptiven Verbesserungsideen zur Arbeitsplatzgestaltung
Authors: Schuh Günther , Potente Till , Gützlaff Andreas , Wlecke Shari , Maetschke Jan , Musa Tarek , Trappmann Ronja 
Published: November 2022

Abstract
Zur Verbesserung eines Arbeitsplatzes bei der Phoenix Contact Electronics GmbH wurde das Hackathon-Konzept auf Lean-Fragestellungen im Sinne eines „Lean Hackathons“ übertragen. Das aus der Software- und Prototypenentwicklung bekannte Konzept des Hackathons ermöglicht die Fokussierung der Autonomie der Mitarbeitenden, um so umsetzbare disruptive Verbesserungen zu erzielen.
Die Auftragsfreigabe – Unterschätzte Aufgabe der Fertigungssteuerung?
Authors: Mütze Alexander , Brug Denis 
Published: November 2022

Abstract
Obwohl die Auftragsfreigabe als Bindeglied zwischen Produktionsplanung und Produktionssteuerung einen immensen Einfluss auf die Auftragsabwicklung und die Zielerreichung einer Produktion hat, scheint ihr in der Praxis eine vergleichsweise niedrige Bedeutung zugeschrieben zu werden. Mit diesem Beitrag sollen daher die PPS-Aufgabe Auftragsfreigabe näher beleuchtet, Entwicklungen und aktuelle Trends identifiziert und eine tiefergehende Auseinandersetzung mit den Verfahren und der Parametrierung dieser angeregt werden.
Prozessoptimierung mithilfe der Prozess-Atlas-Systematik
Authors: Köhler André , Sendler Markus 
Published: November 2022

Abstract
Die Prozess-Atlas-Systematik (PAS) stellt einen evolutionären Ansatz zur Analyse und Gestaltung industrieller Prozesse dar. Sie wurde mithilfe des Übertrags von Theorien der Kartographie entwickelt und zeichnet sich durch eine einfach erlernbare Notation sowie einen breiten Anwendungsbereich aus. Die PAS zwingt ihren Anwender zur Konzentration auf das Wesentliche und legt ein besonderes Augenmerk auf kritische Schnittstellen in der Ablauforganisation. In diesem Beitrag werden zunächst die Vorteile und Defizite etablierter Methoden der Prozessoptimierung anhand einer Nutzwertanalyse am Fallbeispiel der Instandhaltung von Hilfstriebwerken aufgezeigt. Anschließend werden die Anwendung und der Nutzen der PAS anhand des Fallbeispiels aus der Luftfahrtindustrie demonstriert.
Digitaler Schatten zur nachhaltigen Konfiguration von Losgrößen
Authors: Perau Martin , Fulterer Judith , Linnartz Maria , Schröer Tobias , Schuh Günther 
Published: November 2022

Abstract
Die verarbeitende Industrie in Deutschland steht vor der Transformation von der bisher vorherrschenden ökonomisch orientierten Produktion hin zu einer nachhaltigen Produktion. Durch die Anpassung von Parametern der Produktionsplanung und -steuerung, wie z. B. der Losgröße durch u. a. der Konsolidierung von Transportaufwänden oder geringen Reinigungsaufwänden, kann dabei eine nachhaltigere Produktion erreicht werden. Hierfür wurde mittels einer systematischen Methodik ein Digitaler Schatten konzeptioniert, der eine nachhaltige Konfiguration von Losgrößen ermöglicht. Dafür erfolgen eine Aggregation von Daten aus verschiedenen Informationssystemen und die Simulation des Verhaltens eines Produktionssystems bei veränderten Losgrößen. Diese ermöglichen eine optimierte Auslegung der Losgröße basierend auf ökonomischen und ökologischen Zielgrößen.