bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor
Authors: Morse Jared S. , Sheng Yan J. , Hampton J. Trae , Sylvain Lauralee D. , Das Sukant , Alugubelli Yugendar R. , Chen Peng-Hsun Chase , Yang Kai S. , Xu Shiqing , Fierke Carol A. , Liu Wenshe Ray 
Published: September 2022

ABSTRACTThe phage-assisted, active site-directed ligand evolution (PADLE) is a recently developed technique that uses an amber codon-encoded noncanonical amino acid (ncAA) as an anchor to direct phage-displayed peptides to a target for an enhanced ligand identification process. 2-Amino-8-oxodecanoic acid (Aoda) is a ketone-containing ncAA residue in the macrocyclic peptide natural product apicidin that is a pan-inhibitor of Zn2+-dependent histone deacetylases (HDACs). Its ketone serves as an anchoring point to chelate the catalytic zinc ion in HDACs. Using a previously evolved Nε-acetyl-lysyl-tRNA synthetase in combination with tRNAPyl, we showed that Aoda was efficiently incorporated into proteins in Escherichia coli by amber suppression. By propagating an amber codon-obligate phagemid library in E. coli encoding Aoda, we generated an Aoda-containing phage-displayed peptide library. Using this library to conduct PADLE against HDAC8 revealed a 7-mer peptide GH8P01F1 with Aoda-flanking amino acid residues that match existing peptide sequences in identified HDAC8 substrates. Switching Aoda in GH8P01F1 to a more Zn2+-chelating ncAA S-2-amino-8-hydroxyamino-8-oxooctanoic acid (Asuha) led to an extremely potent GH8HA01 that has an HDAC8-inhibition Ki value as 0.67 nM. GH8HA01 and its 5-mer truncation analogue Ac-GH8HA01Δ1Δ7 that has an HDAC8-inhibition Ki value as 0.31 nM represent two most potent HDAC8 inhibitors that have been developed so far and both are highly selective against HDAC8 over the other three tested HDACs, demonstrating the great potential of using PADLE to identify highly potent and selective ligands for targets.
The challenge for the digital age: making learning a part of life
Authors: Fischer Gerhard , Lundin Johan , Lindberg Ola J. 
Published: September 2022

PurposeThe main argument behind this paper is learning in the digital age should not be restricted to creating digital infrastructures for supporting current forms of learning nor taking schools in their current form as God-given, natural entities, but changing current forms of education by developing new frameworks and socio-technical environments for making learning an integral part of life. The authors provide a framework for this argumentation as well as a call-to-action for research on the co-evolution of learning, media, and learning organizations.Design/methodology/approachThis paper theoretically and argumentatively explores the core assumption that the digitalization of society results in challenges and opportunities for learning and education based on fundamental transformations (Collins and Halverson, 2009; Fischer et al., 2020).FindingsThe digital age greatly enhances the opportunities and supports the necessity for “making learning a part of life”. But while the growth of technology is certain, the inevitability of any particular future is not. The impact of schooling goes beyond that new information about computers, the Internet, and social media are integrated into the schools of today. The transformation of schools needs to be informed by an understanding of the impact of mindset formation that will determine people's approach to learning for the rest of their lives. The authors’ framework is focused on moving “beyond gift-wrapping” by not only fixing and existing systems but to change them and not only reforming but transforming them.Originality/valueIt is the authors’ hope that this article will be of interest to many stakeholders (including learners, teachers, curriculum designers, technology experts, parents, and politicians) and provide a foundation for an ongoing debate and informed actions for “Making Learning a Part of Life” in the digital age.
Burnout: personal and work factors in volunteer and career firefighters
Authors: Dias Paulo C. , Oliveira Íris M. , Rodrigues Anabela , Peixoto Ricardo 
Published: September 2022

Purpose
Firefighters are daily confronted with adverse, unpredictable and demanding situations. It is a dangerous profession that puts firefighters at risk of developing burnout. Although the literature has already identified personal and work-related factors of burnout, the examination of specific factors explaining burnout among volunteer and career firefighters is still needed. The purpose of this study is to investigate the explaining role of personal and work-related factors on volunteer and career firefighters’ burnout.

Design/methodology/approach
A nonrandom convenience sample of 250 firefighters (67% volunteer; Mage = 31.88) completed a sociodemographic questionnaire, the Oldenburg Burnout Inventory, the Proactive Coping Scale and a standard of living subscale item. Hierarchical multiple linear regression models were tested. Fisher’s criterion was considered, with p-values lower than 0.05 interpreted as statistically significant.

Findings
Personal and work-related factors accounted for 18% of volunteer and 31% of career firefighters’ variations in burnout. Personal factors offered a greater contribution explaining volunteer and career firefighters’ burnout. Still, variations in the role played by age, family responsibilities, proactive coping and satisfaction with standard of living on burnout were found among volunteer and career firefighters. Taking the work-related factors into account, working in rotative shifts constituted a risk factor for career firefighters’ burnout.

Research limitations/implications
This study advances the understanding about the role of personal and work-related factors in volunteer and career firefighters’ burnout.

Originality/value
This study adds information about specific factors explaining burnout among voluntary and career firefighters. It deepens existing knowledge on variations in the role played by age, family responsibilities, work conditions, proactive coping and satisfaction with standard of living on the burnout of volunteer and career firefighters.
Antecedents of freight transportation for sustainable supply chain in the post-COVID era: an emerging market study
Authors: Dwivedi Ashish , Pratap Saurabh , Zhou Fuli 
Published: September 2022

PurposeIn past years, the global supply chain has witnessed devastating effects of coronavirus (COVID-19) disease. However, the COVID-19 pandemic has renewed the interest of the Sustainable Supply Chain (SSC) stakeholders on sustainability. The stakeholders are now rethinking their business processes and strategy to make them sustainable. In this context, the relevant literature is required to support emerging markets to formulate sustainability-focussed strategies. The purpose of this study is to provide a comprehensive analysis of potential antecedents that leads towards sustainable development of freight transportation in emerging markets.Design/methodology/approachInitially, the antecedents of the Sustainable Freight Transport (SFT) system are derived from the literature survey followed by verification from the experts. Then, the potential antecedents are categorized under four (social, organizational, operational and environmental) broad categories. Afterwards, a Neutrosophic Analytic Network Process (N-ANP) method is employed to obtain the priority weights of the identified potential antecedents.FindingsThe paper identified and ranked 17 antecedents of the SFT system. According to the study’s findings, the top three antecedents of SFT are “the presence of a multimodal transportation system,” “circularity in SFT” and “traffic congestion management”. The results from the study advocate the promotion of existing multi-modal transport facilities which is promising to achieve sustainability. The results suggested the adoption of the digital twin to manage the transport operations.Originality/valueThis study sheds light on how to achieve sustainability in the freight transportation system post-COVID era highlighting the potential antecedents. The study’s findings will assist practitioners in developing SFT strategies in the face of such pandemics in future.
Virtual money laundering: policy implications of the proliferation in the illicit use of cryptocurrency
Authors: Leuprecht Christian , Jenkins Caitlyn , Hamilton Rhianna 
Published: September 2022

Purpose
This study aims to explain how cryptocurrency is leveraged for illicit purposes across the global financial system. Specifically, it establishes how cryptocurrency has been changing the nature of transnational and domestic money laundering (ML). It then assesses the effectiveness of conventional anti-money laundering (AML) policy and legislation against the proliferation of crypto laundering, using Canada as a critical case study.

Design/methodology/approach
Data was collected from court cases and secondary sources to build cross-case trends of cryptocurrency use in ML. Illicit International Political Economy forms the theoretical foundation for this study, whose contribution is situated in the current literature on crypto-ML.

Findings
This study finds that Bitcoin is common among crypto-money launderers, though most also use some form of alt-coin, and that the use of third-party currency exchanges is a prevalent method to create illicit funds and conceal proceeds of crime. The findings validate two hypotheses that illicit use of crypto is prevalent in the first two stages of ML, and that crypto is most often used in conjunction with other fiat currencies. Although law enforcement is improving on monitoring and understanding popular cryptocurrencies such as Bitcoin, alt-coins pose a significant challenge for criminal intelligence. New regulations for third-party currency exchanges are having a positive impact on curtailing crypto-laundering but are shown to be insufficient per se to contain the use of crypto in criminal activity.

Originality/value
This study contributes to a more robust understanding of the use of virtual currency in transnational and domestic ML. It contributes to an emerging body of literature on the role of technological change in enabling the global flow of illicit funds. It also informs public policy on virtual currency in general, and on AML regulation in Canada in particular.
Women on board and the cost of equity: the mediating role of information asymmetry
Authors: Sarang Aitzaz Ahsan Alias , Rind Asad Ali , Al-Faryan Mamdouh Abdulaziz Saleh , Saeed Asif 
Published: September 2022

Purpose
This study aims to examine whether information asymmetry (IA) mediates the relationship between women directors and the cost of equity (COE). Specifically, this study posits that women directors tend to lower the COE through the channel of IA.

Design/methodology/approach
This study uses the US-listed firms’ data from 2002 to 2014, comprising 11,189 firm-year observations. This study measures the COE by aggregating the four unique market-based COE models and apply pooled ordinary least square to estimate our results.

Findings
This study documents that women directors are linked to IA, and that IA is linked to the COE. Furthermore, in the mediation test, IA fully mediates the relationship between women directors and the COE. This study's results also validate the critical mass hypothesis, as the IA shows full mediation between the critical mass of women directors and COE. This study also discusses the limitations and major implications of the results along with possible future directions.

Social implications
This study also supports the positive role of females in improvising the economic performance of the firms and supporting the sustainable development goals-5 (gender equality).

Originality/value
The originality of this study lies in its theoretical as well as empirical contributions. First, this study follows the line of inquiry of the mediation analysis, thereby contributing by examining whether the relationship between women directors and financial value, i.e. COE, is indirect. Second, in addition to ex post measures of the COE, this study used four ex ante unique market-based models to measure the COE. Most of the prior studies just rely on book-based measures or use a single market-based mode. Third, the findings contribute insights into how women directors add value and benefits firms.
Risk management practices and credit risk of the significantly supervised European banks
Authors: Qureshi Anum , Lamarque Eric 
Published: September 2022

PurposeThis paper aims to examine the influence of risk management (RM) practices on the credit risk of significantly supervised European banks.Design/methodology/approachTo avoid regulatory and reporting discrepancies, this paper samples banks that come under the direct supervision of the European Central Bank. Significantly supervised European Banks are selected for the five years from 2013 to 2017. The RM and governance data is manually drawn (from annual reports, registration documents, governance and RM reports), and financial data sets are also used (from Moody’s BankFocus and ORBIS).FindingsThe results indicate that strong risk control and supervision by a powerful chief risk officer (CRO) reduces banks’ credit risk. Banks with sufficiently powerful and independent CROs tend to manage their risks effectively, therefore reporting lower credit risk.Research limitations/implicationsEuropean Union introduced Capital Requirement Directive IV in 2013 and new guidelines on the banks' internal governance in 2017, which were to be implemented in 2018. Thus, this paper limited the sample to five years (from 2013 to 2017) to avoid inconsistencies in the results. Future studies can extend the research and compare banks' credit risk before and after the implementation of regulatory guidelines.Practical implicationsSince the global financial crisis, the regulatory environment has sufficiently changed. Hence, this study reveals that not all RM practices but a few important ones reduce credit risk.Social implicationsEffective risk control and supervision at the bank level can lower credit risk, ultimately enhancing overall financial stability.Originality/valueMost existing studies focus on classic governance indicators to analyze banks’ credit risk; however, this paper considers risk governance indicators which include RM practices used by European banks. Moreover, existing studies in this line focus on the crisis period of 2007–2008. This paper considered the postfinancial crisis period, specifically after the implementation of the Capital Requirements Directive IV at the European level.
Modeling and analysing the barriers to the acceptance of energy-efficient appliances using an ISM-DEMATEL approach
Authors: Aggarwal Gaurav , Jain Vineet , Ajmera Puneeta , Garza-Reyes Jose Arturo 
Published: September 2022

Purpose
Electricity savings from energy-efficient appliances (EEAs) may have a significant impact on reducing global warming. There are several barriers confronted by EEAs, which have lowered their acceptance rate. The current study aims to identify and highlight key barriers to strengthening domestic sector adoption of EEAs in developing countries.

Design/methodology/approach
In the current study, 13 barriers were discovered by an in-depth literature review and the judgement of experts as well. Further, integrated “interpretive structural modeling” (ISM) and “decision-making trial and evaluation laboratory” (DEMATEL) approaches are used to evaluate barriers. The ISM technique is implemented to categorize barriers into distinct hierarchy levels and “cross-impact matrix multiplication applied to classification” (MICMAC) analysis to divide barriers among four clusters “independent, linkage, dependent and autonomous.” Moreover, the DEMATEL methodology is applied to classify the barriers among cause and effect clusters.

Findings
The integrated ISM and DEMATEL approach suggests that the topmost influencing barriers to the acceptance of EEAs are the lack of Government policies and initiatives, lack of attractive loan financing and subsidized energy prices.

Practical implications
This study would help researchers, regulators, producers, policymakers and consumers to comprehend the need for additional developments and understand that the adoption of EEAs is a current need. Overall, the results of this study expedite stakeholders with the key barriers that may assist to enhance the acceptance of EEAs within the domestic sector.

Originality/value
An extensive literature survey showed a dearth of studies for the identification, modeling and analysis of barriers collectively. Therefore, the current work used the ISM and DEMATEL approaches to fill the gap and to provide more comprehensive knowledge on barriers related to the acceptance of EEA.
The nexus between investor sophistication and annuity insurance ownership: evidence from FINRA's National Financial Capability Study
Authors: Korankye Thomas , Pearson Blain , Salehi Hossein 
Published: September 2022

PurposeAlthough annuitization provides insurance against longevity risk that can benefit households, researchers have uncovered an annuitization puzzle, which suggests households are reluctant to annuitize their wealth. This study contributes to the discussions on the annuitization puzzle by examining investor sophistication and owning annuities in non-retirement accounts.Design/methodology/approachThe study utilizes data from the 2018 U S National Financial Capability Study (NFCS). The empirical analyses are based on logistic regression estimates of annuity ownership on investor sophistication. Interpretations are based on odds ratios.FindingsThe findings indicate that investor sophistication contributes to the annuity puzzle. Investors with low objective and high subjective investment knowledge (overconfident investors) are more likely to own annuities compared to those with low objective and low subjective investment knowledge. However, investors with high objective and low subjective investment knowledge (under-confident investors) are less likely to choose annuity ownership compared to those with low objective and low subjective investment knowledge. The findings and ensuing discussion highlight the importance of annuitization when planning for retirement, with implications for financial service professionals.Research limitations/implicationsThe measure of investor sophistication does not assess the difficulty level of each financial knowledge question. The questions used to construct the investor sophistication variable are based on general investment knowledge. In addition, the annuity ownership variable used in this study pertains to investments outside retirement accounts. Despite these limitations, the findings highlight the importance of annuitization when planning for retirement.Originality/valueUnlike prior studies, the authors consider four mutually exclusive measures of investor sophistication constructed from measures of objective and subjective investment knowledge to understand the effect of investor sophistication on annuity ownership in the United States.
Commentary on “A STOMP-focused evaluation of prescribing practices in one assessment and treatment unit for people with intellectual disabilities”
Authors: Gerrard Dave , Rhodes Jen 
Published: September 2022

Purpose
This commentary aims to define STOMP and STAMP, describes its history and evolution and the authors’ thoughts about future directions given the lack of clear evidence base for prescribing and deprescribing psychotropic medication given for behaviour thought to be challenging.

Design/methodology/approach
This commentary defines the authors’ clinical experience and personal thoughts about STOMP achievements and challenges for the future delivery.

Findings
This commentary details STOMP development to date and highlights the potential areas for further study and research to grow understanding, professional confidence and delivery.

Research limitations/implications
This commentary highlights much of the currently accepted research and areas that have poor quality evidence or are of interest for future study. STOMP definition, especially of inappropriate prescribing, is key to redefining the work.

Practical implications
This commentary highlights the potential impact of STOMP and STAMP on prescribing rates and the need for better definition, processes and education for workforce development. There is a major need to understand the benefit of behavioural intervention to support the optimisation of medication.

Originality/value
This commentary builds on personal experience and current understanding to postulate considerations to further the delivery of STOMP and STAMP.
Does IPPM bear fruit? Evaluating reduced‐risk insecticide programmes on pests, pollinators and marketable yield
Authors: Leach Ashley , Pecenka Jacob , Kaplan Ian 
Published: September 2022

Abstract

Integrated pest and pollinator management (IPPM) has been touted as a novel approach to control pests while mitigating negative effects of insecticides on pollinators. In addition to non‐chemical approaches, IPPM programmes focus on insecticide treatments with low bee toxicity, threshold‐based applications and restricted timings to avoid sprays during pollinator foraging. However, the singular and combined effect of this approach on pollination services and pest management is understudied and generally lacks field validation.

In two field studies, we evaluated the effect of IPPM insecticide programmes on striped cucumber beetle (Acalymma vittatum) management, pollination and watermelon yield. The first trial (2020) featured insecticide treatments representing a factorial combination of (1) products varying in bee toxicity (bifenthrin, cyclaniliprole and acetamiprid), (2) application frequencies (weekly vs. threshold‐based) and (3) application timings (AM vs. PM), as well as an untreated control. These data were then used to inform a second trial (2021) that applied two insecticide treatments (IPPM based or grower standard) to commercial‐scale (20–30 acres) fields in collaboration with regional watermelon farms. Weekly beetle densities, pollinator visitation and yield data were collected to determine programme efficacy.

Overall, beetle infestations were successfully managed with all insecticide treatments, none of which compromised marketable yield. In 2020, threshold‐based insecticide programmes offered statistically similar levels of pest control but required 20%–80% fewer applications compared to a weekly programme. Furthermore, pollinator visitation was increased in threshold‐based programmes by ~42% across all products. The on‐farm validation trial in 2021 upheld these findings; IPPM fields had effective beetle control but with 1–7 fewer insecticide applications compared to grower standard fields. IPPM fields also had 62% greater pollinator visitation and 49% more melons during harvest compared to grower standard fields.

Synthesis and applications. Our study demonstrates the capacity of IPPM programmes to manage pests while mitigating negative effects on pollinators. In particular, administering insecticide applications by pest thresholds led to the greatest enhancement in pollinator function. These findings also suggest that growers can benefit from this approach with reduced insecticide costs while encouraging pollination in pollinator‐dependent crops.