bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing risk of aphids spreading plant viruses in maize fields on both sides of China's Heihe‐Tengchong line under climate change
Authors: Li Dexian , Li Zixin , Wang Xiaoxia , Wang Li , Li Yonghong , Liu Deguang 
Published: April 2022

AbstractBACKGROUNDIn the coming decades, geographical distribution patterns of farmland organisms may undergo drastic changes due to climate change, with significant implications for global food security. In China, Rhopalosiphum maidis and its spread of sugarcane mosaic virus (ScMV) can become an increasingly serious threat to maize (Zea mays) production. We conducted ecological niche modeling for Z. mays, R. maidis, and ScMV under current and future (2041–2060 and 2081–2100) climate scenarios by using MaxEnt software to explore changes in this system.RESULTSThe Heihe‐Tengchong line (an imaginary separation line of human population density) can divide China into main (east of the line) and secondary (west of the line) habitats for the three species. With climate change, rapid expansion in suitable areas is projected for ScMV and the aphid vector R. maidis. Taking species interactions into consideration, our overlaying analyses show that most areas east of the Heihe‐Tengchong line (optimal for maize and suitable for R. maidis) will become increasingly highly suitable for ScMV, suggesting that the prevention and control of this plant virus and its aphid vector in China's main maize‐growing areas (e.g. northeast) will become an increasing challenge in the future.CONCLUSIONClimate change will profoundly affect ScMV–vector–maize interactions, which may contribute favorably to invasion of this virus into new areas. Our comprehensive and in‐depth analyses on shifts in this multi‐species system under climate change provide useful and insightful information for devising strategies for the prevention and control of plant viruses and aphid vectors on maize in the future. © 2022 Society of Chemical Industry.
Warmer temperatures reduce chemical tolerance in the redlegged earth mite (Halotydeus destructor), an invasive winter‐active pest
Authors: Thia Joshua A , Cheng Xuan , Maino James , Umina Paul A , Hoffmann Ary A 
Published: April 2022

AbstractBACKGROUNDQuantifying how chemical tolerance of pest arthropods varies with temperature is important for understanding the outcomes of chemical control, for measuring and monitoring resistance, and for predicting how pesticide resistance will evolve under future climate change. We studied the redlegged earth mite, Halotydeus destructor (Tucker), a winter‐active invasive agricultural pest in Australia. Using a replicated block experiment, we tested the effect of different thermal conditions on the expression of chemical tolerance to a pyrethroid and two organophosphates. Our chemical bioassays were conducted on two redlegged earth mite populations: one possessed organophosphate resistance, whilst the other was susceptible to pesticides. Mites were first acclimated at cool (4 °C) and warm (14 °C) conditions and then exposed to pesticides in both cool (11 °C) and warm (18 °C) test conditions.RESULTSWarm test conditions generally reduced chemical tolerance to all pesticides relative to cool test conditions. Median lethal dose (LD50) values of mites tested under cool conditions were 1.12–3.57‐fold greater than of mites tested under warm conditions. Acclimation had a variable and small impact on chemical responses. Thermal factors (ratio between test temperatures) were similar between populations for each active ingredient. Despite reduced chemical tolerances under warm test conditions for individual mite populations, resistance factors (ratio between resistant and susceptible mite populations) were relatively consistent.CONCLUSIONOur data provides context for prior theoretical work demonstrating climatically constrained pesticide resistances in Australian redlegged earth mites. Estimates of temperature dependent toxicity measured in this study may be useful in parameterizing models of redlegged earth mite control under an increasingly warm and more variable climate. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Chinese students at U.K. universities: Transnational education mobilities as a stepping‐stone to adulthood
Authors: Wang Zhe 
Published: April 2022

AbstractThis article explores transnational Chinese students' education migration to the United Kingdom through a lifecourse perspective. Drawing on in‐depth interviews with 43 transnational Chinese graduates from U.K. universities, I found that participants regarded their transnational education migration as a stepping‐stone to adulthood. Influenced by the mobilities paradigm, this paper elaborates on the transitions to adulthood experienced by transnational Chinese students. The findings illustrate how transnational education mobilities transform social networks, in which transnational Chinese students rehearse their role as an adult in everyday social interactions, and how the intersection of Confucian collectivism and students' class background influences their experiences and understandings of transitions to adulthood. Therefore, this paper advances existing scholarship on transnational Chinese students by proposing a lifecourse perspective and exemplifies the complexities of mobile youth's lifecourse transitions by emphasising the cultural and social construction of transnational Chinese students' adulthood.
Quantitative systems pharmacology modeling provides insight into inter‐mouse variability of Anti‐CTLA4 response
Authors: Qiao Wenlian , Lin Lin , Young Carissa , Narula Jatin , Hua Fei , Matteson Andrew , Hooper Andrea , Gruenbaum Lore , Betts Alison 
Published: April 2022

AbstractClinical responses of immuno‐oncology therapies are highly variable among patients. Similar response variability has been observed in syngeneic mouse models. Understanding of the variability in the mouse models may shed light on patient variability. Using a murine anti‐CTLA4 antibody as a case study, we developed a quantitative systems pharmacology model to capture the molecular interactions of the antibody and relevant cellular interactions that lead to tumor cell killing. Nonlinear mixed effect modeling was incorporated to capture the inter‐animal variability of tumor growth profiles in response to anti‐CTLA4 treatment. The results suggested that intratumoral CD8+ T cell kinetics and tumor proliferation rate were the main drivers of the variability. In addition, simulations indicated that nonresponsive mice to anti‐CTLA4 treatment could be converted to responders by increasing the number of intratumoral CD8+ T cells. The model provides a mechanistic starting point for translation of CTLA4 inhibitors from syngeneic mice to the clinic.
Upscaling circular economy in foodtechs businesses in emergent countries: Towards sustainable development through natural resource based view
Authors: Sehnem Simone , Bispo Deivsson Souza , João Jacinto Orlando , de Souza Maria Aparecida Lima , Bertoglio Oscar , Ciotti Rogério , Deon Simone Machado 
Published: April 2022

AbstractThis work adopts sustainable entrepreneurship as its scope of analysis, focusing on sustainable success through startups with operational excellence, technological innovation (TI) and whose business model aligns with the assumptions of circular economy (CE). By applying certain characteristics of the natural resource‐based view (NRBV) in the context of foodtech startups, this study assesses both TIs and CE assumptions adopted by Brazilian foodtech startups. We interviewed managers and owners of foodtech companies operating in the Brazilian economy. Thus, this study relates to CE business models, how well companies manage natural resources, and the influence of TI in promoting CE. After conducting an exploratory case study in Brazil with 15 startups, in addition to exploring the adequacy of four future research proposals, this article suggests that: (a) among the foodtech startups studied, the companies that are most disruptive and innovative also demonstrate a more efficient and optimized management of natural resources; (b) based on these units of analysis, a less proactive CE tends to compete with companies in the traditional segment of operation, not differing in terms of products and services offered to society, thus generating only a small contribution to sustainable development; (c) while our study shows that NRBV illustrates a relevant theoretical framework to confirm the progress of the CE supported by TI, the integration of these theoretical constructs in a startup proves to be original and unprecedented.
Vine water status mapping with multispectral UAV imagery and machine learning
Authors: Tang Zhehan , Jin Yufang , Alsina Maria Mar , McElrone Andrew J. , Bambach Nicolas , Kustas William P. 
Published: April 2022

AbstractOptimizing water management has become one of the biggest challenges for grapevine growers in California, especially during drought conditions. Monitoring grapevine water status and stress level across the whole vineyard is an essential step for precision irrigation management of vineyards to conserve water. We developed a unified machine learning model to map leaf water potential ($${\psi }_{\mathrm{leaf}}$$ψleaf), by combining high-resolution multispectral remote sensing imagery and weather data. We conducted six unmanned aerial vehicle (UAV) flights with a five-band multispectral camera from 2018 to 2020 over three commercial vineyards, concurrently with ground measurements of sampled vines. Using vegetation indices from the orthomosaiced UAV imagery and weather data as predictors, the random forest (RF) full model captured 77% of$${\psi }_{\mathrm{leaf}}$$ψleafvariance, with a root mean square error (RMSE) of 0.123 MPa, and a mean absolute error (MAE) of 0.100 MPa, based on the validation datasets. Air temperature, vapor pressure deficit, and red edge indices such as the normalized difference red edge index (NDRE) were found as the most important variables in estimating$${\psi }_{\mathrm{leaf}}$$ψleafacross space and time. The reduced RF models excluding weather and red edge indices explained 52–48% of$${\psi }_{\mathrm{leaf}}$$ψleafvariance, respectively. Maps of the estimated$${\psi }_{\mathrm{leaf}}$$ψleaffrom the RF full model captured well the patterns of both within- and cross-field spatial variability and the temporal change of vine water status, consistent with irrigation management and patterns observed from the ground sampling. Our results demonstrated the utility of UAV-based aerial multispectral imaging for supplementing and scaling up the traditional point-based ground sampling of$${\psi }_{\mathrm{leaf}}$$ψleaf. The pre-trained machine learning model, driven by UAV imagery and weather data, provides a cost-effective and scalable tool to facilitate data-driven precision irrigation management at individual vine levels in vineyards.
Fibro-fatty remodelling in arrhythmogenic cardiomyopathy
Authors: Kohela Arwa , van Rooij Eva 
Published: April 2022

AbstractArrhythmogenic cardiomyopathy (AC) is an inherited disorder characterized by lethal arrhythmias and a risk to sudden cardiac death. A hallmark feature of AC is the progressive replacement of the ventricular myocardium with fibro-fatty tissue, which can act as an arrhythmogenic substrate further exacerbating cardiac dysfunction. Therefore, identifying the processes underlying this pathological remodelling would help understand AC pathogenesis and support the development of novel therapies. In this review, we summarize our knowledge on the different models designed to identify the cellular origin and molecular pathways underlying cardiac fibroblast and adipocyte cell differentiation in AC patients. We further outline future perspectives and how targeting the fibro-fatty remodelling process can contribute to novel AC therapeutics.
Maximal strength training in patients with inflammatory rheumatic disease: implications for physical function and quality of life
Authors: Haglo Håvard , Berg Ole Kristian , Hoff Jan , Helgerud Jan , Wang Eivind 
Published: April 2022

Abstract
Purpose
Patients with inflammatory rheumatic disease (IRD) have attenuated muscle strength in the lower extremities, resulting in impaired physical function and quality of life. Although maximal strength training (MST), applying heavy resistance, is documented to be a potent countermeasure for such attenuation, it is uncertain if it is feasible in IRD given the pain, stiffness, and joint swelling that characterize the population.

Methods
23 patients with IRD (49 ± 13 years; 20 females/3 males), diagnosed with spondyloarthritis, rheumatoid arthritis, or systemic lupus erythematosus, were randomized to MST or a control group (CG). The MST group performed four × four repetitions dynamic leg press two times per week for 10 weeks at ~ 90% of one repetition maximum (1RM). Before and after training 1RM, rate of force development (RFD), and health-related quality of life (HRQoL) were measured.

Results
Session attendance in the MST group was 95%, of which 95% conducted according to MST protocol. Furthermore, MST increased 1RM (29 ± 12%, p = 0.001) and early and late phase RFD (33–76%, p < 0.05). All improvements were different from the CG (p < 0.05). MST also resulted in HRQoL improvements in the dimensions; physical functioning, general health, and vitality (p < 0.05). Physical functioning was associated with 1RM (rho = 0.55, p < 0.01) and early phase RFD (rho = 0.53–0.71, p < 0.01; different from CG p < 0.05).

Conclusions
Despite being characterized by pain, stiffness, and joint swelling, patients with IRD appear to tolerate MST well. Given the improvements in 1RM, RFD, and HRQoL MST should be considered as a treatment strategy to counteract attenuated muscle strength, physical function, and HRQoL.
Trial registration: ClinicalTrials.gov, NCT04998955, retrospectively registered.
Antibiotic therapy is associated with an increased incidence of cancer
Authors: Roderburg Christoph , Loosen Sven H. , Joerdens Markus S. , Demir Münevver , Luedde Tom , Kostev Karel 
Published: April 2022

Abstract
Purpose
There is a growing body of evidence suggesting the decisive involvement of the human microbiome in cancer development. The consumption of antibiotics may fundamentally change the microbiome and thereby create a precancerous environment promoting cancer development and growth. However, clinical data on the association between the consumption of antibiotics and cancer incidence have remained inconclusive. In this study, we quantified the association between the intake of different antibiotics and various cancer entities among outpatients from Germany.

Methods
This retrospective case–control study based on the IQVIA Disease Analyzer database included 111,828 cancer patients and 111,828 non-cancer controls who were matched to cancer cases using propensity scores. Patients were categorized as non-users, low-consumption (up to 50th percentile), and high-consumption (above 50th percentile) users of antibiotics overall and for each antibiotic class. Multivariable logistic conditional regression models were used to study the association between antibiotic intake within 5 years prior to the index date (first cancer diagnosis for cases or randomly selected date for controls) and cancer incidence.

Results
The probability of cancer was significantly higher among patients with a history of antibiotic intake than in matched controls. Patients using penicillin or cephalosporins displayed a higher incidence of cancer, while the intake of tetracyclines and macrolides actually reduced the risk of cancer development slightly. A complex picture was observed in our cancer site-stratified analyses. Most notably, the consumption of penicillin was significantly and positively associated with cancer development in the respiratory organs only (low consumption OR: 1.33, 95% CI 1.20–1.47; high consumption OR 1.42, 95% CI 1.22–1.64) and cephalosporin consumption was significantly associated with respiratory organ cancer (low consumption OR: 1.32, 95% CI 1.17–1.48, high consumption OR: 1.47, 95% CI 1.29–1.66), breast cancer (high consumption OR: 1.40, 95% CI 1.25–1.56), and lymphoid and hematopoietic tissue cancer (high consumption OR: 1.50, 95% CI 1.35–1.66).

Conclusion
Our data strongly support the hypothesis that the intake of antibiotics is positively associated with the risk of cancer development.
Outcome and prognostic factors in patients undergoing salvage therapy for recurrent esophagogastric cancer after multimodal treatment
Authors: Apostolidis Leonidas , Lang Kristin , Sisic Leila , Busch Elena , Ahadova Aysel , Wullenkord Ramona , Nienhüser Henrik , Billeter Adrian , Müller-Stich Beat , Kloor Matthias , Jaeger Dirk , Haag Georg Martin 
Published: April 2022

Abstract
Purpose
Perioperative systemic treatment has significantly improved the outcome in locally advanced esophagogastric cancer. However, still the majority of patients relapse and die. Data on the optimal treatment after relapse are limited, and clinical and biological prognostic factors are lacking.

Methods
Patients with a relapse after neoadjuvant/perioperative treatment and surgery for esophagogastric cancer were analyzed using a prospective database. Applied treatment regimens, clinical prognostic factors and biomarkers were analyzed.

Results
Of 246 patients 119 relapsed. Among patients with a relapse event, those with an early relapse (< 6 months) had an inferior overall survival (OS 6.3 vs. 13.8 months, p < 0.001) after relapse than those with a late relapse (> 6 months). OS after relapse was longer in patients with a microsatellite-unstable (MSI) tumor. Systemic treatment was initiated in 87 patients (73% of relapsed pat.); among those OS from the start of first-line treatment was inferior in patients with an early relapse with 6.9 vs. 10.0 months (p = 0.037). In 27 patients (23% of relapsed pat.), local therapy (irradiation or surgical intervention) was performed due to oligometastatic relapse, resulting in a prolonged OS in comparison to patients without local therapy (median OS 35.2 months vs. 7.8 months, p < 0.0001). Multivariate analysis confirmed the prognostic benefit of the MSI status and a local intervention.

Conclusion
Patients relapsing after multimodal treatment have a heterogeneous prognosis depending on the relapse-free interval (if systemic treatment applied), extent of metastatic disease as well as MSI status. The benefit of additional local intervention after relapse should be addressed in a randomized trial.
Pulmonary symptoms in adolescent idiopathic scoliosis: a systematic review to identify patient-reported and clinical measurement instruments
Authors: te Hennepe Niek , Faraj Sayf S. A. , Pouw Martin H. , de Kleuver Marinus , van Hooff Miranda L. 
Published: April 2022

AbstractStudy designSystematic review.PurposeAdolescent idiopathic scoliosis (AIS) is a deformity of the trunk and chest and can cause a spectrum of pulmonary symptoms. However, no standardized measurement instrument exists. The aim of this systematic review is to identify and describe patient-reported and clinical measurement instruments used to evaluate pulmonary symptoms in patients with AIS.MethodsStudies published after 01.01.2000 were included in a systematic search. Patient-reported outcome measures (PROMs) and clinical measurement instruments for pulmonary symptoms were extracted as well as their measurement properties (floor-ceiling effects, validity, reliability, responsivity and interpretability). The Risk of Bias (RoB) was evaluated.ResultsOut of 3146 studies, 122 were eligible for inclusion. Seven clinical measurement instruments, measuring 50 measurement parameters, were identified. Five PROMs for pulmonary symptoms were identified. Studies assessing the quality of measurement properties in the AIS population were not identified. As such, the RoB could not be determined.ConclusionNo available adequate patent centric instruments were identified that measure pulmonary functioning and symptoms. Although clinical measurement instruments are regularly used, their use in routine practice does not seem feasible. The measurement properties of some identified PROMs seem promising; however, they have not been validated in an AIS population. As pulmonary symptoms in patients with AIS are still poorly understood, the development of such a construct and potentially a subsequent PROM to routinely measure pulmonary functioning and patient experience is recommended.
Zukunft der terrestrischen Rundfunkfrequenzen
Authors: Gerpott Torsten J. 
Published: April 2022

ZusammenfassungDie Weltfunkkonferenz 2023 wird die Verwendung von ultrahohen Frequenzen im Bereich 470 bis 694 MHz ab 2031 erörtern. In Deutschland setzen sich Betreibende von 1. Rundfunk- und Kultur-, 2. öffentlichen Mobilfunk- sowie 3. Sicherheits-, Katastrophen- und Landesverteidigungsdiensten dafür ein, dass dieses Funkspektrum vor- oder gleichrangig ihren Anwendungen gewidmet wird. Es werden Argumente für und gegen eine primäre Zuordnung der Frequenzen auf die drei Dienstklassen bilanziert. Die Analyse legt nahe, eine kooperative Nutzung des Spektrums für mehrere Dienstklassen bzw. durch verschiedene Bedarfsträger in einem von der Europäischen Union gesetzten Rahmen anzustreben.
Energieversorgungsrisiken, Energiepreiskrise und Klimaschutz erfordern gemeinsame Antworten
Authors: Fischedick Manfred 
Published: April 2022

AbstractIn the past two years, the world has changed and global crises (e. g. the COVID-19 pandemic, war in Ukraine) increasingly dominate the headline. Decades of certainties no longer apply, risks and uncertainties are increasing, challenges are becoming more complex and at the same time require faster and more consistent action. Against that background, the text discusses what we can — and must — learn from the current crises. We must learn that we need to be more sensitive to potential risks and take precautions where necessary and possible, even if this requires pre-emptive financial and structural actions. The text focuses onis the current situation in which we have to find integrative answers reflecting the severe energy supply risks (associated with the energy import dependency from Russia) and the rising and volatile energy prices on the one hand and the climate protection challenge on the other.
Family Social Capital in Family Business: A Faith-Based Values Theory
Authors: Sorenson Ritch L. , Milbrandt Jackie M. 
Published: April 2022

AbstractWhen this study was initiated in 2008, the concept of family social capital was new to the family business discipline. This paper summarizes in-depth qualitative research grounded in owning family experience to understand the nature and source of owning family social capital. Exploratory research began with roundtable discussions among family business owners, advisors, and researchers to understand how owning families sustain positive relationships characteristic of family social capital. These discussions revealed that some family business owners rely on their family faith to sustain and establish ethical norms. A follow-up review in the family studies literature revealed that many families rely on family faith practices and faith-based narratives to reinforce ethical norms that strengthen family relationships. Based on these findings, researchers developed hypotheses to guide additional research. Four owning families affiliated with different Christian denominations participated in in-depth qualitative research that supports hypotheses. Interviews and archival data revealed very similar faith-based practices, beliefs, and values across the four owning families. And additional qualitative evidence indicated positive connections between values-based family social capital and family owner succession, business performance, and community support. Theoretical relationships derived from qualitative data are summarized in a Faith-Based Values Theory of Family Business.