bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protecting those who protect nature by supporting conservationists’ mental wellbeing
Authors: Pienkowski Thomas , Keane Aidan , Tickell Sofia Castelló y , de Lange Emiel , Hazenbosch Mirjam , Khanyari Munib , Arlidge William , Baranyi Gergő , Brittain Stephanie , Kapoor Vena , Mohan Vik , Papworth Sarah , Ravi Roshni , Smit Izak , Milner-Gulland EJ 
Published: January 2022

Abstract
Biodiversity conservation work can be challenging but rewarding, with potential consequences for conservationists’ mental health. Yet, little is known about patterns of mental health among conservationists and its associated protective and risk factors. A better understanding can help improve working conditions, supporting conservationists’ job satisfaction, productivity, and engagement, while reducing costs from staff turnover, absenteeism, and presenteeism. We surveyed 2311 conservationists across 143 countries, asking about experiences of psychological distress, personal characteristics, and workplace conditions. Moderate or severe distress was reported by 27.8%. Respondents with low dispositional and conservation-specific optimism, poor physical health, limited social support, women, and early-career professionals were most at risk. Heavy workload, job demands, and organisational instability were linked to higher distress, but job stability and satisfaction with one’s contributions to conservation were associated with lower distress. We suggest ways employers and others could support conservationists’ mental health and ability to tackle the global ecological crisis.
Livestock Feed Processing and Storage Mechanizims in Bench Maji, Sheka Ad Kaffa Zones, South West Ethiopia
Authors: Milkias Matawork Gobena , Woyamo Wondimu Teka , Genzabu Dessalegn Genzabu 
Published: January 2022

Abstract
This study was conducted in Kaffa, Bench Maji and Sheka zones with the objective of assessing livestock feed processing and storage mechanisms in South West Ethiopia. Purposive sampling technique was used to select study districts based on livestock population, accessibility and availability of feed resources. A total of 384 households having a minimum one hectare of land and livestock were randomly selected for interview. The mean total number of cattle in the study area was 8.48+6.79 per households. Majority of the respondents could not practice livestock feed processing and storage mechanisms in dry and wet season in the study area. The bases for feed provision for livestock in the study area were production level, work load and availability of feed ingredients. Different plants parts were used for livestock to increase milk yield, to improve growth rate and to treat diseases. Livestock production was lowest in dry season due to lack of feed shortage in the dry season. Due to this conclusion, government office should give training how to process and store feeds for dry season.
Towards the Analysis of Urban Livability in China: Spatial-Temporal Changes, Regional Types and Influencing Factors
Authors: Wang Yi , Miao Zhuanying 
Published: January 2022

Abstract
The increasing drift of urbanization and its impact on urban human settlements are of major concern for China cities. Therefore, demystifying the spatial-temporal patterns, regional types and affecting factors of urban livability in China are beneficial to urban planning and policy making regarding the construction of livable cities. In accordance with its connotation and denotation, this study develops a systematic evaluation and analysis framework for urban livability. Drawing on the panel data of 40 major cities in China from 2005 to 2019, an empirical research was further conducted. The results show that urban livability in China has exhibited a rising trend during the period, but this differs across dimensions. The levels of urban security and environmental health are lower than those of the three other dimensions. Spatially, cities with higher livability are mainly distributed in the first quadrant divided by the Hu Line and Bole-Taipei Line. Cities in the third quadrant are equipped with the lowest livability. In addition, the 40 major cities can be divided into five categories, and obvious differences exist in terms of the geographical distribution, overall livability level and sub-dimensional characteristics of the different types. Furthermore, the results of the System GMM estimator indicate that the overall economic development exerts an inhibiting effect on the improvement of urban livability in present-day China, but this logical effect exhibits obvious heterogeneity in different time periods and diverse city scales. Finally, there are also differences in the influencing direction and degree of specific economic determinants.
Terlipressin Attenuates Hemorrhagic Shock-Induced Acute Kidney Injury in Rats
Authors: Castro Leticia Urbano Cardoso , Otsuki Denise Aya , Sanches Talita Rojas , Souza Felipe Lima , Santinho Mirela Aparecida Rodrigues , Silva Cleonice , Noronha Irene Lourdes , Neto Amaro Nunes Duarte , Gomes Samirah Abreu , Malbouisson Luiz-Marcelo Sá , Andrade Lucia 
Published: January 2022

Abstract
Hemorrhagic shock (HS), a major cause of trauma-related mortality, is mainly treated by crystalloid fluid administration, typically with lactated Ringer’s (LR). Despite beneficial hemodynamic effects, such as the restoration of mean arterial pressure (MAP), LR administration has major side effects, including organ damage due to edema. One strategy to avoid such effects is pre-hospitalization intravenous administration of the potent vasoconstrictor terlipressin, which can restore hemodynamic stability/homeostasis and has anti-inflammatory effects. Wistar rats were subjected to HS for 60 min, at a target MAP of 30–40 mmHg, thereafter being allocated to receive LR infusion at 3 times the volume of the blood withdrawn; at 2 times the volume, plus terlipressin (10 µg/100 g body weight); and at an equal volume, plus terlipressin (10 µg/100 g body weight). A control group comprised rats not subjected to HS and receiving no fluid resuscitation or treatment. At 15 min after fluid resuscitation/treatment, the blood previously withdrawn was reinfused. At 24 h after HS, MAP was higher among the terlipressin-treated animals. Terlipressin also improved post-HS survival and provided significant improvements in glomerular/tubular function (creatinine clearance), neutrophil gelatinase-associated lipocalin expression, fractional excretion of sodium, aquaporin 2 expression, tubular injury, macrophage infiltration, IL-6 levels, IL-18 levels, and NF-κB expression. In terlipressin-treated animals, there was also significantly higher ANG II type 1 receptor expression and normalization of AVP 1a receptor expression. Terlipressin could be a viable therapy for HS-induced acute kidney injury, likely attenuating such injury by modulating the inflammatory response via the AVP 1a receptor.
Manual Testing of Respiratory Muscles in Adults with Asthma: A Intra and Interrater Reliability and Validity Study
Authors: Serrano-Villar Yannely , Rodríguez-Grande Eliana-Isabel , Segura María Solange Patiño 
Published: January 2022

Abstract
Background: Manual Muscle Testing (MMT) is a useful tool to evaluate ventilatory mechanics in adults with asthma. However, in the reviewed literature, there are few studies that report psychometric features of this test. Therefore, the present study aimed to evaluate MMT reliability and validity in respiratory muscles in adults with asthma.Methods: It was a cross-sectional study. Muscle strength (MMT and static respiratory pressures), sociodemographic and anthropometric variables related to the disease were evaluated. Measurements were carried out by two independent evaluators The reliability of MMT was analyzed with the weighted kappa and the convergent validity was evaluated by comparing the MTT and the respiratory pressure measurements using Pearson's correlation coefficient. The level of significance was p <0.05. Results: Twenty-six adults with stable asthma participated in the study. The intrarater reliability for MMT was between moderate and substantial (kappa=0.45-0.88) for all evaluated muscles while the interrater reliability was slight and fair for intercostal muscles (kappa=0.07-0.24), and fair and substantial (kappa=0.36-0.75) for other muscles. The convergent validity of MMT and respiratory pressures was low (r=0.20-0.48).Conclusions: MMT is a reliable measurement that can be used to evaluate respiratory muscle strength in adults with asthma. This study support MMT application for respiratory muscles at clinical settings when more objective measures such as MIP and MEP are not available. Considering that the MMT is a useful, practical, low-cost tool commonly used by physiotherapists, future studies could evaluate the convergent validity compared with dynamometry or electromyography of the respiratory muscles.
Kinesin and Myosin Motors Compete to Drive Rich Multi-Phase Dynamics in Programmable Cytoskeletal Composites
Authors: Achiriloaie Daisy , Currie Christopher , Michel Jonathan , Hendija Maya , Lindsay K Alice , Bolef Nadia Schwartz , Lee Gloria , Rust Michael , Sheung Janet , Das Moumita , Ross Jennifer , McGorty Ryan , Robertson-Anderson Rae 
Published: January 2022

Abstract
The cytoskeleton of biological cells relies on a diverse population of motors, filaments, and binding proteins acting in concert to enable non-equilibrium processes ranging from mitosis to chemotaxis. The cytoskeleton’s versatile reconfigurability, programmed by interactions between its constituents, make it a foundational active matter platform. However, current active matter endeavors are limited largely to single force-generating components acting on a single substrate – far from the composite cytoskeleton in live cells. Here, we engineer actin-microtubule composites, driven by kinesin and myosin motors and tuned by crosslinkers, that restructure into diverse morphologies from interpenetrating filamentous networks to de-mixed amorphous clusters. Our Fourier analyses reveal that kinesin and myosin compete to delay kinesin-driven restructuring and suppress de-mixing and flow, while crosslinking accelerates reorganization and promotes actin-microtubule correlations. The phase space of non-equilibrium dynamics falls into three broad classes– slow reconfiguration, fast advective flow, and multi-mode ballistic dynamics – with structure-dynamics relations described by the relative contributions of elastic and dissipative responses to motor-generated forces.
Using Machine Learning to Discover Unexpected Patterns in Clinical Data: A Case Study in COVID-19 Sub-cohort Discovery
Authors: Cowley Hannah Paris , Robinette Michael S. , Matelsky Jordan K. , Xenes Daniel , Kashyap Aparajita , Ibrahim Nabeela F. , Robinson Matthew L. , Zeger Scott , Garibaldi Brian T. , Gray-Roncal William 
Published: January 2022

Abstract
As clinicians are faced with a deluge of new information, data science can play a key role in highlighting key features towards developing new clinical hypotheses. Indeed, insights derived from machine learning can serve as a clinical support tool by connecting care providers with results from big data analysis to identify latent patterns that may not be easily detected by even skilled human observers. In this work, we show an example of collaboration between clinicians and data scientists during the COVID-19 pandemic, identifying subgroups of COVID-19 patients with unanticipated outcomes or who are high-risk for severe disease or death. We apply a random forest classifier model to predict adverse patient outcomes early in the disease course, and we connect our classification results to unsupervised clustering of patient features that may underpin patient risk. The paradigm for using data science for hypothesis generation and clinical decision support, as well as our triage classification approach and unsupervised clustering methods to determine patient cohorts, are applicable to driving rapid hypothesis generation and iteration in a variety of clinical challenges, including future public health crises.
The Addition of Epistatic Genetic Effects Increases Genomic Prediction Accuracy for Reproduction and Production Traits in Duroc Pigs Using Genomic Models
Authors: Cheng Jian , Tiezzi Francesco , Howard Jeremy , Maltecca Christian , Jiang Jicai 
Published: January 2022

Abstract
Background: Genomic selection has been implemented in livestock genetic evaluations for years. However, currently most genomic selection models only consider the additive effects associated with SNP markers and nonadditive genetic effects have been for the most part ignored. Methods: Production traits for 26,735 to 27,647 Duroc pigs and reproductive traits for 5,338 sows were used, including off-test body weight (WT), off-test back fat (BF), off-test loin muscle depth (MS), number born alive (NBA), number born dead (NBD), and number weaned (NW). All animals were genotyped with the PorcineSNP60K Bead Chip. Variance components were estimated using a linear mixed model that includes inbreeding coefficient, additive, dominance, additive-by-additive, additive-by-dominance, dominance-by-dominance effect, and common litter environmental effect. Genomic prediction performance, including all nonadditive genetic effects, was compared with a reduced model that included only additive genetic effect. Results: Significant estimates of additive-by-additive effect variance were observed for NBA, BF, and WT (31%, 9%, and 10%, respectively). Production traits showed significant large estimates of additive-by-dominance variance (9%-23%). MS also showed large estimate of dominance-by-dominance variance (10%). Dominance effect variance estimates were low for all traits (0%-2%). Compared to the reduced model, prediction accuracies using the full model, including nonadditive effects, increased significantly by 12%, 12%, and 1% for NBA, WT, and MS, respectively. A strong dominance association signal with BF was identified near AK5.Conclusions: Sizable estimates of epistatic effects were found for the reproduction and production traits, while the dominance effect was relatively small for all traits yet significant for all production traits. Including nonadditive effects, especially epistatic effects in the genomic prediction model, significantly improved prediction accuracy for NBA, WT, and MS.
Three-dimensional Alignment of the Upper Extremity in the Standing Neutral Position in Healthy Subjects
Authors: Yoshida Yuki , Matsumura Noboru , Yamada Yoshitake , Hiraga Satoshi , Ishii Kazunori , Oki Satoshi , Yokoyama Yoichi , Yamada Minoru , Nakamura Masaya , Nagura Takeo , Jinzaki Masahiro 
Published: January 2022

Abstract
Background: Though alignment of the spine and lower extremities in the standing neutral position has been evaluated, a few studies evaluating the alignment of the upper extremities have also been made. This study assessed the normal alignment of the upper extremities in the standing neutral position and clarified the three-dimensional angular rotations of the upper extremity joints.Methods: Computed tomography (CT) images of 158 upper extremities from 79 healthy volunteers were prospectively acquired in the standing neutral position using an upright CT scanner. Three-dimensional coordinate systems of the thorax, scapula, humerus, and forearm were designated, and three-dimensional angular rotations of the scapulothoracic, glenohumeral, and elbow joints were calculated.Results: The mean angle of the scapulothoracic joint was 8.5° ± 5.9° of upward rotation, 28.7° ± 5.9° of internal rotation, and 7.9° ± 5.2° of anterior inclination. The mean angle of the glenohumeral joint was 4.4° ± 5.9° of abduction, 9.4° ± 12.3° of internal rotation, and 0.3° ± 4.4° of extension. The mean angle of the elbow joint was 9.6° ± 3.7° of valgus, 88.8° ± 14.3° of pronation, and 15.4° ± 4.2° of flexion. Correlations in angular rotation values were found, and interactions for keeping the upper extremities in a neutral position were observed.Conclusions: This study clarified the three-dimensional angular rotation of upper extremity joints in the standing neutral position using an upright CT scanner. Our results may provide important insights for the functional evaluation of upper extremity alignment.
Influence of Different Dielectrics on Process Performance for Electrical Discharge-Assisted Milling of Titanium Alloy
Authors: Xu Moran , Li Changping , Kurniawan Rendi , Chen Jielin , Ko Tae Jo 
Published: January 2022

Abstract
Electrical discharge-assisted milling (EDAM) is an effective method for machining titanium alloys according to previous research. In this study, the influence of three different dielectrics (kerosene, EDM oil, and deionized water) on the EDAM performance was studied. Experimental studies reveal the influence of different dielectrics by analyzing the discharged signal, surface morphology, and elemental composition of the electrode. The results show that kerosene and EDM oil have a higher discharge frequency than deionized water. After a long discharge time, carbides and debris were generated during the machining process, which affected the micro-hardness and the discharge stability of the machined material. In EDAM, EDM oil can produce the best surface quality, and the surface roughness value was 34.93%, 87.92%, and 121.68% higher than that of kerosene, deionized water, and conventional milling (CM), respectively.
The safety and cost-analysis of simultaneous versus staged bilateral total knee arthroplasty in a Taiwan population
Authors: Chou Te-Feng Arthur , Ma Hsuan-Hsiao , Hsu Yu-Chun , Tsai Chi-Wu , Tsai Shang-Wen , Chen Cheng-Fong , Chiu Fang-Yao , Wu Po-Kuei , Chen Tain-Hsiung , Chen Wei-Ming 
Published: January 2022

Abstract
The purpose of this study was to investigate the safety of Simultaneous, bilateral TKA (SiTKA). Furthermore, we also assessed the cost reduction of SiTKA in comparison with Staged, bilateral TKA (StTKA). We retrospectively review all patients that underwent SiTKA or StTKA due to osteoarthritis (OA) or spontaneous osteonecrosis of the knee (SONK).We assessed length of stay, transfusion rate, early postoperative complications, 30-day and 90-day readmission rate, 1-year reoperation rate and the indication for reoperation. Furthermore, we analyzed the total cost of the two groups, reimbursement from the national health insurance (NHI), cost of the procedures, and net income from each case. A total of 2016 patients (1565 SiTKA and 451 StTKAs) were included in this study. There were no significant differences in terms of complication rates, 30-day and 90-day readmission, and 1-year reoperations between the two groups. The total length of stay was on average 5.0 days longer for StTKA (p<0.01). In terms of cost, all categories of medical costs were significantly lower in SiTKA, while the net hospital income was significantly higher for StTKA. In conclusion, SiTKA and StTKA have similar postoperative complication, readmission and reoperation rates, while SiTKA significantly reduces medical expenses for the patient and NHI. Level of evidence: level III, retrospective cohort study
Numerical and Experimental Validation of Gas Metal Arc Welding on AISI 441 Ferritic Stainless Steel Through Mechanical and Microstructural Analysis
Authors: CARUSO SERAFINO , UMBRELLO DOMENICO 
Published: January 2022

Abstract
Residual stresses and strains, distortion, heat affected zone (HAZ), grain size changes and hardness variation during gas metal arc welding (GMAW), are fundamental aspects to study and control during welding processes. For this reason, numerical simulations of the welding processes represent the more frequently used tool to better analyse the several aspects characterizing this joining process with the aim to reduce lead time and production costs. In the present study an uncoupled 3D thermo-mechanical analysis was carried out by two commercial finite element method (FEM) software to model an experimental single bead GMAW of AISI 441 at different process set-up. The experimental HAZ and measured temperatures were used to calibrate the heat source of both the used numerical codes, then a validation procedure was done to test the robustness of the two developed analytical procedures. One software was used to predict the residual stresses and strains and the distortions of the welded components, while in the second software a user routine was implemented, including a physical based model and the Hall-Petch (H-P) equation, to predict grain size change and hardness evolution respectively. The results demonstrate that the predicted mechanical and microstructural aspects agree with those experimentally found showing the reliability of the two codes in predicting the thermal phenomena characterizing the HAZ during the analysed welding process.
Disrupting The Resting State: Meta-Analytic Evidence That Mindfulness Training Alters Default Mode Network Connectivity
Authors: Rahrig Hadley , Vago David R. , Passarelli Matthew , Auten Allison , Lynn Nicholas A. , Brown Kirk Warren 
Published: January 2022

Abstract
This meta-analysis sought to expand upon neurobiological models of mindfulness through investigation of inherent brain network connectivity outcomes, indexed via resting state functional connectivity (rsFC). We conducted a systematic review and meta-analysis of rsFC as an outcome of mindfulness training (MT) relative to structurally-equivalent programs, with the hypothesis that that MT would increase cross-network connectivity between nodes of the Default Mode Network (DMN), Salience Network (SN), and Frontoparietal Control Network (FPCN) as a mechanism of internally-oriented attentional control. Texts were identified from the databases: MEDLINE/PubMed, ERIC, PSYCINFO, ProQuest, Scopus, and Web of Sciences; and were screened for inclusion based on experimental/quasi-experimental trial design and use of standardized mindfulness-based interventions. RsFC effects were extracted from twelve studies (mindfulness n = 226; control n = 204). Voxel-based meta-analysis revealed significantly greater rsFC (MT > control) between the left middle cingulate (Hedge’s g = .234, p = 0288, I2 = 15.87), located within the SN, and the posterior cingulate cortex, a focal hub of the DMN. Egger’s test for publication bias was nonsignificant, bias = 2.17, p = .162. In support of our hypothesis, results suggest that MT targets internetwork (SN-DMN) connectivity implicated in the flexible control of internally-oriented attention.
A universal deep learning-based framework towards fully ab initio simulation of atmospheric aerosol nucleation
Authors: Jiang Shuai , Liu Yi-Rong , Huang Teng , Feng Ya-Juan , Wang Chun-Yu , Wang Zhong-Quan , Ge Bin-Jing , Liu Quan-Sheng , Guang Wei-Ran , Huang Wei 
Published: January 2022

Abstract
Atmospheric aerosol nucleation contributes to around half of cloud condensation nuclei globally. Despite the importance for climate, detailed nucleation mechanisms are still poorly understood. Understanding aerosol nucleation dynamics is hindered by non-reactivity of force fields and high computational costs due to rare event nature of aerosol nucleation. Developing reactive force fields for nucleation systems are even more challenging than covalently bonded materials because of wide size range and high dimensional characteristics of non-covalent hydrogen bonding bridging clusters. Here we proposes a system transferable framework to train an accurate reactive force field (FF) based on deep neural network (DNN) and further bridges the DNN-FF based molecular dynamics (MD) with cluster kinetics model based on Poisson distributions of reactive events to overcome high computational costs from direct MD. We found that previously reported acid-base formation rates tend to be underestimated several times, emphasizing acid-base nucleation observed in multiple environments should be revisited.