bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis
Authors: Li Ying , Tang Mengyao , Zhang Feng Jun , Huang Yihan , Zhang Jing , Li Junqi , Wang Yunpeng , Yang Jinguang , Zhu Shu 
Published: November 2022

Abstract
Background
Ulcerative colitis (UC) refers to an intractable intestinal inflammatory disease. Its increasing incidence rate imposes a huge burden on patients and society. The UC etiology has not been determined, so screening potential biomarkers is critical to preventing disease progression and selecting optimal therapeutic strategies more effectively.

Methods
The microarray datasets of intestinal mucosal biopsy of UC patients were selected from the GEO database, and integrated with R language to screen differentially expressed genes and draw proteins interaction network diagrams. GO, KEGG, DO and GSEA enrichment analyses were performed to explore their biological functions. Through machine learning and WGCNA analysis, targets that can be used as UC potential biomarkers are screened out. ROC curves were drawn to verify the reliability of the results and predicted the mechanism of marker genes from the aspects of immune cell infiltration, co-expression analysis, and competitive endogenous network (ceRNA).

Results
Two datasets GSE75214 and GSE87466 were integrated for screening, and a total of 107 differentially expressed genes were obtained. They were mainly related to biological functions such as humoral immune response and inflammatory response. Further screened out five marker genes, and found that they were associated with M0 macrophages, quiescent mast cells, M2 macrophages, and activated NK cells in terms of immune cell infiltration. The co-expression network found significant co-expression relationships between 54 miRNAs and 5 marker genes. According to the ceRNA hypothesis, NEAT1-miR-342-3p/miR-650-SLC6A14, NEAT1-miR-650-IRAK3, and XIST-miR-342-3p-IRAK3 axes were found as potential regulatory pathways in UC.

Conclusion
This study screened out five biomarkers that can be used for the diagnosis and treatment of UC, namely SLC6A14, TIMP1, IRAK3, HMGCS2, and APOBEC3B. Confirmed that they play a role in the occurrence and development of UC at the level of immune infiltration, and proposed a potential RNA regulatory pathway that controls the progression of UC.
The biomechanical behavior of 3D printed human femoral bones based on generic and patient-specific geometries
Authors: Nägl Katharina , Reisinger Andreas , Pahr Dieter H. 
Published: November 2022

Abstract
Background
Bone is a highly complex composite material which makes it hard to find appropriate artificial surrogates for patient-specific biomechanical testing. Despite various options of commercially available bones with generic geometries, these are either biomechanically not very realistic or rather expensive.

Methods
In this work, additive manufacturing was used for the fabrication of artificial femoral bones. These were based on CT images of four different commercially available femoral bone surrogates and three human bones with varying bone density. The models were 3D printed using a low-budget fused deposition modeling (FDM) 3D printer and PLA filament. The infill density was mechanically calibrated and varying cortical thickness was used. Compression tests of proximal femora simulating stance were performed and the biomechanical behavior concerning ultimate force, spring stiffness, and fracture pattern were evaluated as well as compared to the results of commercial and cadaveric bones.

Results
Regarding the ultimate forces and spring stiffness, the 3D printed analogs showed mechanical behavior closer to their real counterparts than the commercially available polyurethan-based surrogates. Furthermore, the increase in ultimate force with increasing bone density observed in human femoral bones could be reproduced well. Also, the fracture patterns observed match well with fracture patterns observed in human hip injuries.

Conclusion
Consequently, the methods presented here show to be a promising alternative for artificial generic surrogates concerning femoral strength testing. The manufacturing is straightforward, cheap, and patient-specific geometries are possible.
Supervised Hebbian learning
Authors: Alemanno Francesco , Aquaro Miriam , Kanter Ido , Barra Adriano , Agliari Elena 
Published: November 2022

Abstract
In neural network's literature, Hebbian learning traditionally refers to the procedure by which the Hopfield model and its generalizations store archetypes (i.e., definite patterns that are experienced just once to form the synaptic matrix). However, the term learning in machine learning refers to the ability of the machine to extract features from the supplied dataset (e.g., made of blurred examples of these archetypes), in order to make its own representation of the unavailable archetypes. Here, given a sample of examples, we define a supervised learning protocol based on Hebb's rule and by which the Hopfield network can infer the archetypes. By an analytical inspection, we detect the correct control parameters (including size and quality of the dataset) that tune the system performance and we depict its phase diagram. We also prove that, for structureless datasets, the Hopfield model equipped with this supervised learning rule is equivalent to a restricted Boltzmann machine and this suggests an optimal and interpretable training routine. Finally, this approach is generalized to structured datasets: we highlight an ultrametric-like organization (reminiscent of replica-symmetry-breaking) in the analyzed datasets and, consequently, we introduce an additional broken-replica hidden layer for its (partial) disentanglement, which is shown to improve MNIST classification from

to

, and to offer a new perspective on deep architectures.
Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions
Authors: Weng Anthea , Rabin Erik E. , Flozak Annette S. , Chiarella Sergio E. , Aillon Raul Piseaux , Gottardi Cara J. 
Published: November 2022

ABSTRACT
The adherens junction component, alpha-T-catenin (αTcat) is an established contributor to cardiomyocyte junction structure and function, but recent genomic studies link CTNNA3 polymorphisms to diseases with no clear cardiac underpinning, including asthma, autism and multiple sclerosis, suggesting causal contributions from a different cell-type. We show Ctnna3 mRNA is highly expressed in peripheral nerves (e.g. vagus and sciatic), where αTcat protein enriches at paranodes and myelin incisure adherens junctions of Schwann cells. We validate αTcat immunodetection specificity using a new Ctnna3-knock-out fluorescence reporter mouse line yet find no obvious Schwann cell loss-of-function morphology at the light microscopic level. CTNNA3/Ctnna3 mRNA is also abundantly detected in oligodendrocytes of the central nervous system via public databases, supporting a general role for αTcat in these unique cell–cell junctions. These data suggest that the wide range of diseases linked to CTNNA3 may be through its role in maintaining neuroglial functions of central and peripheral nervous systems.
This article has a corresponding First Person interview with the co-first authors of the paper.
Towards achieving lightweight intrusion detection systems in Internet of Things, the role of incremental machine learning: A systematic literature review
Authors: Agbedanu Promise Ricardo , Musabe Richard , Rwigema James , Gatare Ignace , Maginga Theofrida Julius , Amenyedzi Destiny Kwabla 
Published: November 2022

While the benefits of IoT cannot be overstated, its computational constraints make it challenging to deploy security methodologies that have been deployed in traditional computing systems. The benefits and computational constraints have made IoT systems attractive to cyber-attacks. One way to mitigate these attacks is to detect them. In this study, a Systematic Literature Review (SLR) has been conducted to analyze the role of incremental machine learning in achieving lightweight intrusion detection for IoT systems. The study analyzed existing incremental machine learning approaches used in designing intrusion detection systems for IoT ecosystems, emphasizing the incremental methods used in detecting intrusions, the datasets used to evaluate these methods, and how the method achieves lightweight status. The SLR outlined the contributions of each study, focusing on their strengths and gaps, the datasets used, and the incremental machine learning model used. This study revealed that incremental learning approaches in detecting intrusion in IoT systems are in their infant stage. Over 12 years, from 2010 to 2022, a total of twenty-one (21) studies were carried out in IDSs using incremental machine learning, with eight (8) studies carried out in IoT systems. In addition to reviewing the literature, we offer suggestions for improving existing solutions and achieving lightweight IDS for IoT systems. We also discussed some problems with making lightweight IDS for IoT systems and areas where more research could be done in the future.
Study of Stress Resistance Among Students of the Direction of Training «Personnel Management» in the Process of Adaptation to the University
Authors: Perederiy V. , Skripnichenko L. , Skorobogatov V. 
Published: November 2022

The purpose of the study was to identify stress symptoms in students and resources that positively affect the adaptation process at the university, which affect the level of stress resistance of students during their adaptation to the educational environment.
During the survey (sample – 225 students) (212 girls and 13 boys)) and expert interviews (psychological service workers, members of the faculty of the Kuban State University of the Krasnodar Territory who carry out educational work with students of the first and second courses of study were interviewed (curators and deputy deans for educational work, n = 12)) confirmed the need for a comprehensive study combining socio-psychological and individual typological directions in determining the level of stress resistance of students in the process of adaptation to the educational environment.
Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon
Authors: Tashi Tenzin , Upadhye Aditi , Kundu Prasun , Wu Chunxiang , Menant Sébastien , Soares Roberta Reis , Ferreira Marcelo U. , Longley Rhea J. , Mueller Ivo , Hoang Quyen Q. , Tham Wai-Hong , Rayner Julian C. , Scopel Kézia KG , Lima-Junior Josué C. , Tran Tuan M. 
Published: November 2022

Background
To make progress towards malaria elimination, a highly effective vaccine targeting Plasmodium vivax is urgently needed. Evaluating the kinetics of natural antibody responses to vaccine candidate antigens after acute vivax malaria can inform the design of serological markers of exposure and vaccines.

Methodology/Principal findings
The responses of IgG antibodies to 9 P. vivax vaccine candidate antigens were evaluated in longitudinal serum samples from Brazilian individuals collected at the time of acute vivax malaria and 30, 60, and 180 days afterwards. Antigen-specific IgG correlations, seroprevalence, and half-lives were determined for each antigen using the longitudinal data. Antibody reactivities against Pv41 and PVX_081550 strongly correlated with each other at each of the four time points. The analysis identified robust responses in terms of magnitude and seroprevalence against Pv41 and PvGAMA at 30 and 60 days. Among the 8 P. vivax antigens demonstrating >50% seropositivity across all individuals, antibodies specific to PVX_081550 had the longest half-life (100 days; 95% CI, 83–130 days), followed by PvRBP2b (91 days; 95% CI, 76–110 days) and Pv12 (82 days; 95% CI, 64–110 days).

Conclusion/Significance
This study provides an in-depth assessment of the kinetics of antibody responses to key vaccine candidate antigens in Brazilians with acute vivax malaria. Follow-up studies are needed to determine whether the longer-lived antibody responses induced by natural infection are effective in controlling blood-stage infection and mediating clinical protection.
Bacteriologically confirmed extrapulmonary tuberculosis and the associated risk factors among extrapulmonary tuberculosis suspected patients in Ethiopia: A systematic review and meta-analysis
Authors: Diriba Getu , Alemu Ayinalem , Eshetu Kirubel , Yenew Bazezew , Gamtesa Dinka Fikadu , Tola Habteyes Hailu 
Published: November 2022

Background
The actual burden of bacteriologically confirmed extrapulmonary tuberculosis (EPTB) and risk factors in Ethiopia is not well known due to the lack of a strong surveillance system in Ethiopia. Thus, this study was conducted to estimate the pooled prevalence of bacteriologically confirmed EPTB and the associated risk factors among persons suspected to have non-respiratory tuberculosis in Ethiopia.

Methods
A systematic review and meta-analysis of published studies reporting the prevalence of EPTB from searched electronic databases; Science Direct, PubMed, and Google Scholar was estimated spread across the research periods, nationally, and in different areas, using a fixed-effects model. We used I2 to analyze heterogeneity in the reported prevalence of bacteriologically confirmed extrapulmonary tuberculosis.

Results
After reviewing 938 research articles, 20 studies (19 cross-sectional and 1 retrospective) from 2003 to 2021 were included in the final analyses. The pooled prevalence of bacteriologically confirmed EPTB was 43% (95%CI; 0.34–0.52, I2 = 98.45%). The asymmetry of the funnel plot revealed the presence of publication bias. Specifically the pooled prevalence of bacteriologically confirmed EPTB based on smear microscopy, Xpert MTB/RIF assay, and culture were 22% (95%CI; 0.13–0.30, I2 = 98.56%), 39% (95%CI; 0.23–0.54, I2 = 98.73%) and 49% (95%CI; 0.41–0.57, I2 = 96.43%) respectively. In this study, a history of pulmonary tuberculosis (PTB) contact with PTB patients, contact with live animals, consumption of raw milk, HIV-positive, male, and lower monthly income, were found to be independently associated with bacteriologically confirmed EPTB.

Conclusion
Ethiopia has a high rate of bacteriologically confirmed EPTB. A history of previous PTB, being HIV-positive and having contact with PTB patients were the most reported risk factors for EPTB in the majority of studies. Strengthening laboratory services for EPTB diagnosis should be given priority to diagnose EPTB cases as early as possible.
Evaluation of metabolic dysfunction-associated fatty liver disease using FibroScan, diet, and microbiota: A large cross-sectional study
Authors: Tateda Tetsuyuki , Iino Chikara , Sasada Takafumi , Sato Satoshi , Igarashi Go , Kawaguchi Shogo , Mikami Kenichiro , Endo Tetsu , Sawada Kaori , Mikami Tatsuya , Fukuda Shinsaku , Nakaji Shigeyuki , Sakuraba Hirotake 
Published: November 2022

Objective
We evaluated the clinical characteristics of metabolic dysfunction-associated fatty liver disease (MAFLD) to evaluate the usefulness of the MAFLD diagnostic criteria in a resident health survey.

Methods
In 1056 participants of a health survey, we compared obesity, diabetes, metabolic dysregulation, FibroScan-aspartate aminotransferase (FAST) score, dietary habits, and gut microbiota between healthy individuals and participants with MAFLD and Nonalcoholic fatty liver disease (NAFLD).

Results
The proportion of participants with MAFLD in the fatty liver was higher than that with NAFLD (88.1% vs. 75.5%, respectively). Of 36 participants with a FAST score > 0.35, 29 (80.6%) participants had MAFLD and 23 (63.9%) participants had NAFLD. Of 29 patients with liver fibrosis, 26 (89.7%) participants had obesity and metabolic dysregulation. In the evaluation of diet, the total energy, protein, dietary fiber, and salt intake were significantly higher in participants with MAFLD than those in participants without fatty liver. In the microbiota analysis, the results of the linear discriminant analysis effect size analysis revealed nine bacterial genera that were significantly different in participants with MAFLD in comparison with participants without fatty liver. Of these genera, the relative abundance of Blautia was especially low in participants with MAFLD.

Conclusion
In a resident health survey, participants with MAFLD had a higher proportion of fatty liver than those with NAFLD. MAFLD criteria could help in improved screening of participants with liver fibrosis. Therefore, the MAFLD criteria could be a useful diagnostic tool for aggressively identifying participants with a high risk of fatty liver. Additionally, Blautia might be involved in the development of MAFLD.
Movement in low gravity environments (MoLo) programme–The MoLo-L.O.O.P. study protocol
Authors: Herssens Nolan , Cowburn James , Albracht Kirsten , Braunstein Bjoern , Cazzola Dario , Colyer Steffi , Minetti Alberto E. , Pavei Gaspare , Rittweger Jörn , Weber Tobias , Green David A. 
Published: November 2022

Background
Exposure to prolonged periods in microgravity is associated with deconditioning of the musculoskeletal system due to chronic changes in mechanical stimulation. Given astronauts will operate on the Lunar surface for extended periods of time, it is critical to quantify both external (e.g., ground reaction forces) and internal (e.g., joint reaction forces) loads of relevant movements performed during Lunar missions. Such knowledge is key to predict musculoskeletal deconditioning and determine appropriate exercise countermeasures associated with extended exposure to hypogravity.

Objectives
The aim of this paper is to define an experimental protocol and methodology suitable to estimate in high-fidelity hypogravity conditions the lower limb internal joint reaction forces. State-of-the-art movement kinetics, kinematics, muscle activation and muscle-tendon unit behaviour during locomotor and plyometric movements will be collected and used as inputs (Objective 1), with musculoskeletal modelling and an optimisation framework used to estimate lower limb internal joint loading (Objective 2).

Methods
Twenty-six healthy participants will be recruited for this cross-sectional study. Participants will walk, skip and run, at speeds ranging between 0.56–3.6 m/s, and perform plyometric movement trials at each gravity level (1, 0.7, 0.5, 0.38, 0.27 and 0.16g) in a randomized order. Through the collection of state-of-the-art kinetics, kinematics, muscle activation and muscle-tendon behaviour, a musculoskeletal modelling framework will be used to estimate lower limb joint reaction forces via tracking simulations.

Conclusion
The results of this study will provide first estimations of internal musculoskeletal loads associated with human movement performed in a range of hypogravity levels. Thus, our unique data will be a key step towards modelling the musculoskeletal deconditioning associated with long term habitation on the Lunar surface, and thereby aiding the design of Lunar exercise countermeasures and mitigation strategies.
ANÁLISE HIDROLÓGICA DAS NASCENTES DA BACIA DO ALTO CURSO DO RIO UBERABA
Authors: Abdala Vera Lúcia , Torres Jose Luiz Rodrigues , Barreto Antônio Carlos 
Published: November 2022

A qualidade e a quantidade de água de uma região são determinadas pelos processos naturais e pela influência antrópica nas áreas de recarga das nascentes. O objetivo deste estudo foi mapear a rede de drenagem e realizar a análise hidrológica das nascentes dos principais córregos da área de proteção ambiental (APA) do rio Uberaba. Utilizou-se carta topográfica do IBGE (Folha Uberaba), na escala 1:100.000, em formato digital, imagem Landsat 7 ETM+, bandas 3R, 4G e 7B, resolução 30 m, projeção ortogonal e CIBERS. Utilizou-se o Sistema de Informação Geográfico (SIG), processamento digital de margens (PDI) e os Softwares SPRING, ENVI 4.0 e AutoCadMap2000i.	O sistema de drenagem da área de proteção ambiental (APA) do rio Uberaba apresenta ramificações de primeira e segunda ordem, principalmente nas bordas da chapada; a rede de drenagem da bacia caracteriza-se por ter um padrão dendrítico; as declividades predominantes na APA do rio Uberaba são menores que 10%; a sustentação hídrica do rio Uberaba no período da seca é feita pelos córregos que tem nascentes na borda da chapada.
ANÁLISE SOBRE A EROSÃO HÍDRICA NA ÁREA URBANA DE UBERLÂNDIA (MG)
Authors: Carrijo Beatriz Rodrigues , Baccaro Claudete Aparecida Dallevedove 
Published: November 2022

This paper is the result of some reflections elaborated during a research accomplished in the year of 1998 on to erosive processes in the urban area of Uberlândia (MG). They were mapeaded areas together with erosive processes with a rising about the
current situation of the areas with punctual problems. In general, it was verified that the municipal district didn't still adopt a satisfactory environmental politics for the resolution of those problems.
EXCLUSÃO SOCIAL EM UBERLÂNDIA: ALGUMAS REFLEXÕES A PARTIR DO BAIRRO DOM ALMIR E SEU ENTORNO
Authors: Ramires Julio Cesar de Lima , Santos Márcia Andréia F. 
Published: November 2022

The aim of this article is to present a geographical and socioeconomic characterization of an peripherical space of the city of Uberlândia. This carcterization will be used as subsidies to understand the problems of health in this area, that will be done in a
subsequent stage of our research.

Key words - social exclusion, urban periphery, urban space
O PROCESSO DE GESTÃO DAS ÁGUAS E A QUESTÃO AMBIENTAL NA BACIA DO RIO ARAGUARI
Authors: Gobbi Wanderléia A. de Oliveira , Cleps Junior João , Pessôa Vera Lúcia Salazar 
Published: November 2022

The environmental complications caused by the Green Revolution have been a problem after 1980's. Since then, Sustainable Development has been a point of
discussion in many meetings about environmental problems. Among natural resources, water became an important element to be analyzed. Taken out of this context, the Basin of Araguari River in Minas Gerais State is the object of this study.

Key words: Araguari River, Hydrographic Basin Committee, Water Management.
A SECA E AS HUMANIDADES NO PROCESSO DE ACESSO À ÁGUA: AS BARRAGENS DO RIO SALINAS E O DESENVOLVIMENTO REGIONAL
Authors: Magalhães Maria Araci , Lima Samuel do Carmo 
Published: November 2022

This work is a synthesis of the dissertation about environmental, social, culture, economical impacts have ocurred in Salinas'region - MG, with the building of the
dikes in the Caraíbas, Salinas, Bananal rivers. Check the tranformations have ocurred in the landscapes, in the life conditions of population included and its economical development.

Key words: water, lifes, development