bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptability and User Experiences of a Patient-Held Smart Card for Antenatal Services in Nigeria: A Qualitative Study
Authors: Itanyi Ijeoma Uchenna , Iwelunmor Juliet , Olawepo John , Gbadamosi Semiu , Ezeonu Alexandra , Okoli Adaeze , Ogidi Amaka Grace , Conserve Donaldson , Powell Byron , Onoka Chima Ariel , Ezeanolue Echezona Edozie 
Published: January 2022

Abstract
Background
Poor maternal, newborn and child health outcomes remain a major public health challenge in Nigeria. Mobile health (mHealth) interventions such as patient-held smart cards have been proposed as effective solutions to improve maternal health outcomes. Our objectives were to assess the acceptability and experiences of pregnant women with the use of a patient-held smartcard for antenatal services in Nigeria.
Methods
Using focus group discussions, qualitative data were obtained from 35 pregnant women attending antenatal services in four Local Government Areas (LGAs) in Benue State, Nigeria. The audio-recorded data were transcribed and analyzed using framework analysis techniques such as the PEN-3 cultural model as a guide.
Results
The participants were 18-44 years of age (median age: 24 years), all were married and the majority were farmers. Most of the participants had accepted and used the smartcards for antenatal services. The most common positive perceptions about the smartcards were their ability to be used across multiple health facilities, the preference for storage of the women’s medical information on the smartcards compared to the usual paper-based system, and shorter waiting times at the clinics. Notable facilitators to using the smartcards were its provision at the “Baby showers” which were already acceptable to the women, access to free medical screenings, and ease of storage and retrieval of health records from the cards. Costs associated with health services was reported as a major barrier to using the smartcards. Support from health workers, program staff and family members, particularly spouses, encouraged the participants to use the smartcards.
Conclusion
These findings revealed that patient-held smart card for maternal health care services is acceptable by women utilizing antenatal services in Nigeria. Understanding perceptions, barriers, facilitators, and supportive systems that enhance the use of these smart cards may facilitate the development of lifesaving mobile health platforms that have the potential to achieve antenatal, delivery, and postnatal targets in a resource-limited setting.
Innovative nanomaterials for bone remains consolidation: performance evaluation and impact on 14C dating and on palaeogenetic analysis
Authors: Porpora Francesca , Zaro Valentina , Liccioli Lucia , Modi Alessandra , Meoli Arianna , Marradi Giulia , Barone Serena , Vai Stefania , Dei Luigi , Caramelli David , Fedi Mariaelena , Lari Martina , Carretti Emiliano 
Published: January 2022

Abstract
An innovative protocol for the consolidation of ancient bone remains based on the use of nanometric hydroxyapatite (HAP) was set up and tested through a multidisciplinary approach. A new protocol for the synthesis of HAP nanoparticles was developed, and the composition of the obtained nanomaterial were investigated through Fourier Transform Infrared Spectroscopy (FTIR) and X-Ray Diffraction (XRD); sizes, shape and morphology of the synthesized particles were studied by Scanning Electron Microscopy (SEM). The consolidation performance was evaluated by testing the new nanomaterial on degraded ancient bone findings. An increase of the mineral density and of the micro-hardness of the bone were observed. The new consolidation method was also tested to assess possible effects on the palaeogenetic analysis and radiocarbon dating on the treated bones. The consolidation treatment has no substantial impact on the genetic characterisation of the skeletal remains and does not introduce any contaminations that could affect radiocarbon dating. This consolidation procedure represents a more compatible conservation tool with respect to traditional procedures: it has been shown that the treatment is effective, easily-applicable and not detrimental for 14C dating and palaeogenetic analysis.
The Neutrophil to Lymphocyte Ratio and Serum Albumin as Predictors of Acute Kidney Injury After Coronary Artery Bypass Grafting
Authors: Ishikawa Masashi , Iwasaki Masae , Namizato Dai , Yamamoto Makiko , Morita Tomonori , Ishii Yosuke , Sakamoto Atsuhiro 
Published: January 2022

Abstract
Postoperative acute kidney injury (AKI) is a highly prevalent and serious complication after cardiac surgery. The aim of this study is to identify the predictors of AKI and the cut-off values after isolated off-pump coronary artery bypass grafting (OPCAB). A total of 329 adult patients, who underwent isolated OPCAB between December 2008 and February 2021, were retrospectively analyzed. The patients were divided into three groups: non-AKI, early AKI and late AKI groups. The early AKI group or the late AKI group were defined as ‘having AKI that occurred before or after 48 hours postoperatively’, respectively. Multivariate logistic regression analysis was performed to identify the predictors of AKI. Receiver operating characteristic (ROC) curve analysis was used to evaluate the cutoff value, the sensitivity, and the specificity of the predictors. On the multivariate analysis, the emergency surgery, the preoperative serum albumin, and the postoperative day 1 neutrophil to lymphocyte ratio (NL ratio) were identified as the independent predictors of AKI. However, neither albumin nor the NL ratio predicted late AKI. The present study showed the preoperative albumin and the postoperative day 1 NL ratio were the robust and independent predictors of postoperative early AKI in isolated OPCAB.
Right Superior Temporal Gyrus Altered Functional Activity in Patients With Definite Vestibular Migraine
Authors: Yang Xu , Li Zhe-Yuan , Si Li-Hong , Shen Bo , Ling Xia 
Published: January 2022

Abstract
The study aimed to investigate resting-state functional brain activity alterations in patients with definite vestibular migraine (dVM). Seventeen patients with dVM, 8 patients with migraine, 17 health controls (HCs) were recruited. The amplitude of low frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) were calculated to observe the changes in spontaneous brain activity. Then brain regions with altered fALFF were selected for seed-based functional connectivity analysis. Compared with HCs, VM patients showed significantly increased ALFF values in the right temporal lobe (Cluster size = 91 voxels, P=0.002, FWE corrected), and significantly increased ReHo values in the right superior temporal gyrus (STG), middle temporal gyrus (MTG) and inferior temporal gyrus (ITG) (Cluster size = 136 voxels, P=0.013, FWE corrected). Compared with patients with migraine, patients with VM showed significantly increased fALFF values in the right parietal lobe (Cluster size = 43 voxels, P=0.011, FWE corrected) and right frontal lobe (Cluster size =36 voxels, P=0.026, FWE corrected), significantly increased ReHo values in the right thalamus (Cluster size = 92 voxels, P=0.043, FWE corrected). Our findings documented that patients with VM showed enhanced spontaneous functional activity in the right temporal lobe (STG, MTG, and ITG) compared with HCs, and increased spontaneous activity in the right parietal lobe-frontal lobe-thalamus compared with patients with migraine. Patients with VM and migraine both had altered brain function, but the regions involved are different.
Serum IgG4 Concentration is a Potential Predictive Biomarker in Glucocorticoid Treatment for Idiopathic Retroperitoneal Fibrosis
Authors: Mukai Shoichiro , Sakamoto Naotaka , Kakinoki Hiroaki , Shibuya Tadamasa , Moriya Ryosuke , Nishihara Kiyoaki , Noguchi Mitsuru , Shin Toshitaka , Fujimoto Naohiro , Igawa Tsukasa , Ishii Tatsu , Haga Nobuhiro , Enokida Hideki , Eto Masatoshi , Kamba Tomomi , Sakai Hideki , Saito Seiichi , Terada Naoki , Kamoto Toshiyuki 
Published: January 2022

Abstract

Objectives: To evaluate the management and outcome of idiopathic retroperitoneal fibrosis (iRPF) in Japan, and identify its clinical biomarker. Methods: We retrospectively analyzed 129 patients with iRPF treated between January 2008 and May 2018 at 12 university and related hospitals. Patients treated with glucocorticoid were analyzed to identify a predictive biomarker. These patients were classified into three groups according to overall effectiveness (no change: NC, complete response: CR and partial response groups: PR), and each parameter was compared statistically.Results: Male-female ratio was 5: 1, and median age at diagnosis was 69 (33-86) years. Smoking history was reported in 59.6% of the patients. As treatment, 95 patients received glucocorticoid therapy with an overall response rate of 84%. As a result, serum concentration of IgG4 was significantly decreased in NC group compared with the other two groups (56.6mg/dL vs 255mg/dL, 206mg/dL, P=0.0059 and 0.0078). ROC analysis was performed between the non-responder (NC) and responder groups (CR+PR) to identify the cut-off value of serum IgG4 as a predictive marker. As a result, AUC was 0.793 and the values of sensitivity and specificity were 0.85 and 0.64, respectively, under the cut-off values of 67.6mg/dL. Conclusions: In the majority of iRPF patients, glucocorticoid therapy resulted in a favorable response. Pre-treatment serum IgG4 concentration may have potential as a predictive biomarker of steroid treatment.
Ferroelectricity Modulates Polaronic Coupling at Multiferroic Interfaces
Authors: Husanu Marius-Adrian , Popescu Dana , Hrib Luminita , Negrea Raluca , Istrate Cosmin , Pintilie Lucian , Teodorescu Cristian , Bisti Federico , Lev Leonid , Mishchenko Andrey , Schmitt Thorsten , Pasuk Iuliana , Filip Lucian , Strocov Vladimir 
Published: January 2022

Abstract
Physics of the multiferroic interfaces is currently understood mostly within a phenomenological framework including screening of the polarization field and depolarizing charges. Largely unexplored still remains the band dependence of the interfacial charge modulation, as well as the associated changes of the electron-phonon interaction, coupling the charge and lattice degrees of freedom.
Here, multiferroic heterostructures of the colossal-magnetoresistance manganite La1-xSrxMnO3 buried under ferroelectric BaTiO3 and PbZrxTi1-xO3 are explored using soft-X-ray angle-resolved photoemission. The experimental band dispersions from the buried La1-xSrxMnO3 identify coexisting two-dimensional hole and three-dimensional electron charge carriers. The ferroelectric polarization modulates their charge density, changing the band filling and orbital occupation in the interfacial region. Furthermore, these changes in the carrier density affect the coupling of the 2D holes and 3D electrons with the lattice which forms large Froelich polarons inherently reducing mobility of the charge carriers. We find that the fast dynamic response of electrons makes them much more efficient in screening of the electron-lattice interaction compared to the holes. Our k-resolved results on the orbital occupancy, band filling and electron-lattice interaction in multiferroic oxide heterostructures modulated by the ferroelectric polarization disclose most fundamental physics of these systems needed for further progress of beyond-CMOS ferro-functional electronics.
Quantized wrinkles and fracture of stiff membranes on soft films
Authors: Meng Yancheng , Xiang Henggao , Zhang Jianqiang , Hu Zhili , Yin Jun , Li Liqiang , Zhang Zhuhua , Guo Wanlin 
Published: January 2022

Abstract
Stiff membranes on soft substrates may wrinkle and fold during compression1-11, but the strong post-buckling nonlinearity3,12 and the propensity of overall bending of these systems4,9,11 under large compression make the intriguing morphological evolution ill-controlled and less understood. Here, we present a simple peeling strategy that controllably makes stiff nanomembranes on soft microfilms wrinkled, then folded with a preset period, and ultimately fractured into regular ribbons. The fold and fracture periods exhibit a quantized, stepped dependence on the microfilm thickness, with the period doubled per step. The controlled wrinkle-to-fold-to-fractures transitions can be quantified by both computations and a scaling law, showing generality to different forms of compressive loading. This quantized wrinkle evolution deepens our understanding of complex behaviors of such natural and artificial systems as cerebral cortexes, skins, and coating materials, and opens a way to advanced manufacturing by fracturing large-area nanomembranes into uniformly shaped microflakes.
Complete Genome Sequence of Pseudomonas Stutzeri S116 Provides Insights into the Mechanism of Microbial Fuel Cells
Authors: Li Peng , Yuan Wenfeng , Huang Yitie , Zhang Caiyu , Ni Chide , Lin Qi , Zhu Zhihuang , Wang Jianxin 
Published: January 2022

Abstract
To identify suitable biocatalysts applied in microbial fuel cells (MFCs), Pseudomonas stutzeri S116 isolated from marine sludge was investigated, which possessed excellcent bioelectricity generation ability (BGA). Herein, P. stutzeri as a bioanode and biocathode achieved maximum output voltage (254.2 mV and 226.0 mV), and power density of (765 mW/m2 and 656.6 mW/m2). Complete genome sequencing of P. stutzeri was performed to reveal its potential microbial functions. The results exhibited that the strain was the ecologically dominant Pseudomonas, and its primary annotations were associated with energy production and conversion (6.84%), amino acid transport and metabolism (6.82%) and inorganic ion transport and metabolism (6.77%). The thirty-six genes involved in oxidative phosphorylation indicate that strain possesses an integrated electron transport chain. Moreover, many genes encoding redox mediators (mainly riboflavin and phenazine) were detected in the databases. Simultaneously, thiosulfate oxidization and dissimilatory nitrate reduction were annotated in the sulfur metabolism and nitrogen metabolism pathway. Gene function and cyclic voltammetry (CV) analysis indicated BGA of P. stutzeri probably was attributed to its cytochrome c and redox mediators, which enhance extracellular electron transfer (EET) rate.
Osteopontin as a Tumor Marker in Ovarian Cancer
Authors: Rani Shikha , Sehgal Alka , Kaur Jasbinder , Pandher Dilpreet Kaur , Punia RPS 
Published: January 2022

Abstract
Introduction: Ovarian cancer is associated with high morbidity and mortality. This is due to the nonspecific symptoms and no effective screening methods. Currently CA 125 is used as a tumor biomarker for the diagnosis of ovarian cancer, but it has its own limitations. So, there is need for other tumor biomarkers for the diagnosis of ovarian cancer. To determine the diagnostic test characteristics of plasma osteopontin (OPN) in detecting ovarian malignancy and comparing its performance with carbohydrate antigen-125 (CA 125). Methods: This is a prospective cross-sectional diagnostic test evaluation. Women with adnexal mass detected by clinical or radiological examination were enrolled as suspected cases. Women who presented with other gynecological conditions were enrolled as controls. OPN and CA 125 levels were measured in all enrolled subjects. Results: Among 106 women enrolled, 26 were ovarian cancer, 31 had benign ovarian masses and 49 were controls. Median plasma CA 125 levels were higher in subjects with ovarian cancer (298 U/ml; IQR 84-1082 U/ml vs. 37.5U/ml; IQR 17.6-82.9U/ml; P<0.001).CA 125 sensitivity, specificity, positive and negative likelihood ratios were 88.5%, 61.3%,2.10 and 0.19 respectively. Median plasma OPN levels were higher in subjects with ovarian cancer (63.1 ng/ml; IQR 39.3-137 ng/ml vs. 27ng/ml; IQR 20-52ng/ml; P=0.001). Sensitivity, specificity, positive and negative likelihood ratios of OPN were 50%,87%,2.58 and 0.62, respectively. Conclusion: OPN levels were higher in ovarian cancer than in the benign ovarian mass and had better specificity than CA125. OPN can better differentiate between benign and malignant ovarian mass as compared to CA125.
Benefits of Sustained Physical Activity From Middle-Age To Early Old Age On Quality Of Life In Early Old Age
Authors: Lee Mikyung , Lee Hyeonkyeong , Song Ki Jun , Lee Young-Me 
Published: January 2022

Abstract
This secondary data analysis study aimed to examine the changes in physical activities (PAs) over time (2009-2017) in the same participants and to determine an association between changes in PA and health-related quality of life (HRQoL) in early older adults (n=994) using data from the Korea Health Panel Survey. The HRQoL was measured using the EuroQol quality-of-life system and the amount of PA were grouped to 4 activity levels (remained inactive, became inactive, became active, and remained active). The association of changes in PA over 8 years with HRQoL was examined using logistic regression analysis while controlling for socioeconomic and behavioral factors. The total PA decreased from 1,859.72±1,760.01 MET-minutes in 2009 to 1,264.80 ±1,251.14 MET-minutes in 2017 (P < 0.001). In 2017, 142 (14.3%) remained inactive, whereas 419 (42.2%) remained active. The participants who remained inactive at early old age were more likely to be at the lowest 10% HRQoL of the sample (odds ratio = 1.95, 95% confidence interval = 1.09–3.48). This indicates that educating middle-aged adults who are relatively inactive must be a priority in order to maintain and improve PA, enhance HRQoL, and maximize the benefits of PA in old age.
Endoscopic Cyanoacrylate Injection Treatment for Refractory High-risk Peptic Ulcer Bleeding by Conventional Endoscopic Therapy
Authors: Tuo Biguang , Mou Haijun , Zou Cheng , Shi Guoqing , Wu Sheng , Xie Rui , Liu Xuemei , Yang Jie 
Published: January 2022

Abstract
Bleeding is a major and potentially life-threatening complication of peptic ulcer. Despite endoscopic hemostatic therapy advance, conventional endoscopic hemostatic modalities remain refractory for peptic ulcer bleeding with big size, fibrous base or in difficult-to-access anatomical locations. In this study, we attempted to evaluate the efficacy and safety of endoscopic cyanoacrylate injection treatment (ECIT) for refractory high-risk peptic ulcer bleeding by conventional endoscopic therapy. The patients with refractory high-risk peptic ulcer bleeding by conventional endoscopic therapy were carried out ECIT. The data were retrospectively collected. A total of 119 patients accepted ECIT. 74 patients (62.18%) obtained successful intravascular injection and perivascular injection was performed in 45 patients (37.82%). Immediate hemostatic rate for active bleeding achieved 90.91%. Rebleeding rate within 30 days was 12.07%. Overall successful hemostasis rate achieved 87.93%. Immediate hemostatic rate and overall successful hemostasis rate in intravascular injection patients were markedly superior over perivascular injection. Rebleeding rate in intravascular injection patients was markedly lower than that in perivascular injection patients. 11 patients complicated abdominal pain and no other complication occurred. In conclusion, ECIT, especial intravascular injection, was effective and safe, with high successful hemostasis rate for refractory high-risk peptic ulcer bleeding by conventional endoscopic therapy.
Content Comparison of Long-Term Care Instruments Based On The International Classification of Functioning, Disability And Health (ICF)
Authors: Gao Yan , Zhao Jingpu , Liu Xiangxiang , Xie Xiaohua , Wang Yulong 
Published: January 2022

Abstract
Background: Aging crisis is proposing a huge challenge to the whole Chinese social welfare system, however a national Long-term Care (LTC) Instrument has not established yet. The objective of this study was to analyze and compare the content of six selected LTCs based on the linkage of the International Classification of Functioning, Disability and Health (ICF), so as to provide insights for the development of Chinese national LTC instrument in the future. Methods: Two trained health professionals performed the linkage according to the refined ICF linking rules. The main concepts included in the items of three international LTC instruments, namely Minimum Data Set 3.0 (MDS 3.0), Initial Assessment Instrument(IAI), and New Assessment Tool for Determining Dependency on Nursing Care (NBA), as well as three Chinese instruments, namely Disability Assessment of Long-Term Care (DA-LTC), Specification for Elderly Care Unified Need Assessment in Shanghai Version 2.0 (SEC-UNA 2.0), and pictorial-based Longshi Scale (LS) were selected and linked to the ICF categories. The six selected LTC instruments were analyzed and compared at the levels of ICF components, chapters, and categories. Results: The main concepts of 340 valid items of the six LTC instruments were linked to 112 different ICF categories. Within the ICF framework, the “Activities and Participation” component was most frequently addressed in the LTC instruments followed by the “Body functions” component, and the percentages were 0.52 and 0.38, respectively. At the ICF chapters level, “b1 mental functions,” “d4 mobility,” and “d5 self-care” were the core of the LTC instruments. In addition, the contents of the six selected LTC instruments differed greatly. Conclusions: The ICF provides a useful external reference for the analysis and comparison of different LTC instruments. The findings suggest that key elements to determine eligibility for LTC in China need to be further identified. It is anticipated that this study will provide new insights for the development of Chinese national LTC instruments.
Determinants of improved cookstove adoption and its benefits in Ethiopia.
Authors: Kare Sintayehu , Alemu Abera , Mulugeta Melese , Ganewo Zerhun 
Published: January 2022

Abstract
BackgroundBiomass is the most dominant source of energy for both food cooking and lighting in rural parts of Ethiopia. Energy conversions are carried out in open fires using inefficient traditional stoves, results in poor quality of life due to smoking-related health outcomes, and consume a large quantity of wood. This resulted in increased costs of health and cutting trees which facilities climate change. To change the situation, improved cooking stoves (ICS) have been introduced through youth cooperatives in the study area.Objective The study examined the major sources of energy for the rural households, evaluate the health and related benefits of using improved cook stove and assessing the determinants for its adoption.MethodData were collected from 344 households using a questionnaire in supplement with interview schedule. The collected data were analyzed using both descriptive and econometric models.ResultsThe findings of the study showed that only 22.97% of the respondents adopted the ICS whereas the vast majority (67.03%) still rely on traditional stoves that are highly inefficient. The positive and significant variables in predicting the adoption of ICS were the educational level of household head (OR 1.23; CI at 95% 0.029-0.040), access to ICS (OR 5.88; CI at 95% 1.05-2.48), affordability (OR 2.31; CI at 95% 0.11-1.56) and demonstration about the stove (OR 6.74; CI at 95% 1.13-2.68). Family size (OR 0.74; CI at 95% -0.45-0.12) and Availability of firewood (OR 0.27; CI at 95% -2.00-.56) significantly and negatively affected the adoption of the ICS.ConclusionsLow adoption levels of ICS were found in the study area. This has been triggered by socio-economic, institutional, financial, and resource endowments. Therefore, it is recommended that increasing access to improved stoves, diversifying income sources, creating awareness about ICS health benefits, climate changes, and providing reasonable prices will facilitate its adoption.