bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Topical Chloramphenicol for Eye Diseases in the Outpatient Setting
Authors: Ahmad Nehad J. , Hamdi Abdullah I. , Binduhaim Nawaf , Alkhulifi Hesham A. , Menshawy Menshawy A. 
Published: January 2022

Aim: The present study was conducted to evaluate the outpatient prescribing pattern of ophthalmic chloramphenicol in a public hospital in Alkharj.
Methodology: This is a retrospective study that includes reviewing the electronic prescriptions of ophthalmic chloramphenicol among outpatients in a public hospital in Alkharj.
Results: During the study period from 1st of January 2018 to the end of June 2018, 168 patients received ophthalmic chloramphenicol. More than 50 % of them were males and the age of 55.95% of them was less than 20 years. More than 46% of the ophthalmic chloramphenicol prescriptions were prescribed for 7 Days and 39.29% were prescribed for 5 days. More than 83% of the prescriptions were prescribed by emergency department.
Conclusion: The present study showed that ophthalmic chloramphenicol was uncommonly prescribed in Al-Kharj. Further studies are needed to explore the appropriateness of its prescribing and its use in order to decrease the bacterial resistance and to increase its efficacy.
Association between severe lumbar disc degeneration and self-reported occupational physical loading
Authors: Salo Sami , Hurri Heidi , Rikkonen Toni , Sund Reijo , Kröger Heikki , Sirola Joonas 
Published: January 2022

Abstract

Objectives
Occupational physical loading has been reported to be associated with intervertebral disc degeneration. However, previous literature reports inconsistent results for different vertebral levels. The aim of our study was to investigate the association between lumbar disc degeneration (LDD) at different vertebral levels and the self-reported physical loading of occupation.

Methods
The study population consisted of 1,022 postmenopausal women and was based on the prospective Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study cohort. The severity of LDD was graded from T2-weighted MRI images using the five-grade Pfirrmann classification. Five intervertebral levels (L1–L2 to L5–S1) were studied (total 5110 discs). The self-rated occupational physical loading contained four groups: sedentary, light, moderate, and heavy.

Results
The heavy occupational physical loading group had higher odds for severe LDD at the L5–S1 vertebral level (OR 1.86, 95% CI: 1.19–2.92, p = .006) in comparison with the sedentary work group. A clear trend of increasing disc degeneration with heavier occupational loading was also observed at the L5–S1 level. Age, smoking, and higher body mass index (BMI) were associated with more severe LDD. Leisure-time physical activity at the age of 11–17 years was associated with less severe LDD. Controlling for confounding factors did not alter the results.

Conclusions
There appears to be an association between occupational physical loading and severe disc degeneration at the lower lumbar spine in postmenopausal women. Individuals in occupations with heavy physical loading may have an increased risk for work-related disability due to more severe disc degeneration.
Comparison of an in‐house hybrid DIR method to NiftyReg on CBCT and CT images for head and neck cancer
Authors: Jiang Chunling , Huang Yuling , Ding Shenggou , Gong Xiaochang , Yuan Xingxing , Wang Shaobin , Li Jingao , Zhang Yun 
Published: January 2022

AbstractAn in‐house hybrid deformable image registration (DIR) method, which combines free‐form deformation (FFD) and the viscous fluid registration method, is proposed. Its results on the planning computed tomography (CT) and the day 1 treatment cone‐beam CT (CBCT) image from 68 head and neck cancer patients are compared with the results of NiftyReg, which uses B‐spline FFD alone. Several similarity metrics, the target registration error (TRE) of annotated points, as well as the Dice similarity coefficient (DSC) and Hausdorff distance (HD) of the propagated organs at risk are employed to analyze their registration accuracy. According to quantitative analysis on mutual information, normalized cross‐correlation, and the absolute pixel value differences, the results of the proposed DIR are more similar to the CBCT images than the NiftyReg results. Smaller TRE of the annotated points is observed in the proposed method, and the overall mean TRE for the proposed method and NiftyReg was 2.34 and 2.98 mm, respectively (p < 0.001). The mean DSC in the larynx, spinal cord, oral cavity, mandible, and parotid given by the proposed method ranged from 0.78 to 0.91, significantly higher than the NiftyReg results (ranging from 0.77 to 0.90), and the HD was significantly lower compared to NiftyReg. Furthermore, the proposed method did not suffer from unrealistic deformations as the NiftyReg did in the visual evaluation. Meanwhile, the execution time of the proposed method was much higher than NiftyReg (96.98 ± 11.88 s vs. 4.60 ± 0.49 s). In conclusion, the in‐house hybrid method gave better accuracy and more stable performance than NiftyReg.
Specific Clearance of Senescent Synoviocytes Suppresses the Development of Osteoarthritis based on Aptamer‐Functionalized Targeted Drug Delivery System
Authors: Chen Xiang , Zhang Lei , Shao Xiaoyan , Gong Wang , Shi Tianshu , Dong Jian , Shi Yong , Shen Siyu , He Yi , Qin Jianghui , Lu Jun , Jiang Qing , Guo Baosheng 
Published: January 2022

AbstractAge‐related diseases are among the leading causes of morbidity worldwide currently. Therefore, there is an urgent need to develop effective interventions to reduce aging. In mice, the selective elimination of senescent cells via senolytics extends the median lifespan and attenuates various age‐related diseases including osteoarthritis (OA). However, most classified senolytics may also affect non‐senescent cells because of their suboptimal specificity for senescent cells, which hampers the translation of senolytic therapies to human diseases. Precise targeting of senolytics to specific senescent cell types may help circumvent these potential hurdles. In the joints of OA, abundant senescent fibroblast‐like synoviocytes (FLSs) are observed in the synovium region, which can promote the degradation of chondrocytes. Here, an aptamer‐functionalized liposome (LS) is developed, which encapsulates with senolytics (dasatinib and quercetin, DQ), termed as CX3‐LS‐DQ. This CX3‐LS‐DQ exhibits high affinity for FLS, a reasonably long circulation time, minimal toxicity, and strong clearance ability in senescent FLS. In the OA mouse model, intra‐articular injection of CX3‐LS‐DQ effectively attenuates cartilage degradation in vivo. Overall, the FLS‐specific aptamer‐functionalized drug delivery system could act as a novel carrier for targeted drug delivery to the synovium, providing a foundation for potential clinical translation in OA therapy.
Periodic Nanoarray of Graphene pn‐Junctions on Silicon Carbide Obtained by Hydrogen Intercalation
Authors: Karakachian Hrag , Rosenzweig Philipp , Nguyen T. T. Nhung , Matta Bharti , Zakharov Alexei A. , Yakimova Rositsa , Balasubramanian Thiagarajan , Mamiyev Zamin , Tegenkamp Christoph , Polley Craig M. , Starke Ulrich 
Published: January 2022

AbstractGraphene pn‐junctions offer a rich portfolio of intriguing physical phenomena. They stand as the potential building blocks for a broad spectrum of future technologies, ranging from electronic lenses analogous to metamaterials in optics, to high‐performance photodetectors important for a variety of optoelectronic applications. The production of graphene pn‐junctions and their precise structuring at the nanoscale remains to be a challenge. In this work, a scalable method for fabricating periodic nanoarrays of graphene pn‐junctions on a technologically viable semiconducting SiC substrate is introduced. Via H‐intercalation, 1D confined armchair graphene nanoribbons are transformed into a single 2D graphene sheet rolling over 6H‐SiC mesa structures. Due to the different surface terminations of the basal and vicinal SiC planes constituting the mesa structures, different types of charge carriers are locally induced into the graphene layer. Using angle‐resolved photoelectron spectroscopy, the electronic band structure of the two graphene regions are selectively measured, finding two symmetrically doped phases with p‐type being located on the basal planes and n‐type on the facets. The results demonstrate that through a careful structuring of the substrate, combined with H‐intercalation, integrated networks of graphene pn‐junctions could be engineered at the nanoscale, paving the way for the realization of novel optoelectronic device concepts.
High‐Throughput Production of Cheap Mineral‐Based Heterostructures for High Power Sodium Ion Capacitors
Authors: Xiao Xuhuan , Duan Xuegang , Song Zirui , Deng Xinglan , Deng Wentao , Hou Hongshuai , Zheng Renji , Zou Guoqiang , Ji Xiaobo 
Published: January 2022

AbstractThe high‐throughput scalable production of inexpensive and efficient electrode materials at high current densities demanded by industry is a huge challenge for large‐scale implementation of energy storage technologies. Here, inspired by theoretical calculations that a FeS2/TiO2 heterostructure with built‐in electric field (BEF) can reduce the reaction energy barrier and enhance charge transport, the scalable production of cheap FeS2/TiO2 heterostructure is fabricated by utilizing natural ilmenite as precursor, exhibiting excellent electrochemical performances for sodium‐ion capacitors (SICs) anode. Assembling it with activated carbon (AC) cathode for SICs delivers high energy density (73.7 Wh kg−1) and high power density (10 kW kg−1) as well as outstanding cycle lifespan. Impressively, the method breaks through the traditional preparation approach by using natural minerals instead of high‐purity chemical raw materials as precursors for constructing heterojunctions, and price of the mineral is nearly five orders of magnitude lower than that of commercial chemical raw materials with high‐purity, which greatly reduces raw materials cost and is available for mass production. Similarly, the method can be extended to utilize other minerals to construct heterostructures, thus achieving expanded electrochemical performance, which exhibits huge potentials in electrochemical energy storage.
Synergetic Anion Vacancies and Dense Heterointerfaces into Bimetal Chalcogenide Nanosheet Arrays for Boosting Electrocatalysis Sulfur Conversion
Authors: Ye Zhengqing , Jiang Ying , Li Li , Wu Feng , Chen Renjie 
Published: January 2022

AbstractVacancy and interface engineering are regarded as effective strategies to modulate the electronic structure and enhance the activity of metal chalcogenides. However, the practical application of metal chalcogenides in lithium−sulfur (Li−S) batteries is limited by their low conductivity, rapid decline in catalytic activity, and large volume variation during the discharging/charging process. Herein, bimetal sulfide (CoZn‐S) nanosheet arrays with sulfur vacancies and dense heterointerfaces are proposed to accelerate sulfur conversion and improve the performance of Li−S batteries. Systematic investigations reveal that sulfur‐vacancy and build‐in interfacial field in CoZn‐S facilitate the electron transfer and regulate the electronic structure. The well‐designed 3D nanosheet array structures shorten the ion‐transport pathway and inhibit the volume fluctuation of CoZn‐S during the electrocatalysis process. Density functional theory studies confirm that the built‐in interfacial field and sulfur vacancy can promote the thermodynamic formation and decomposition of Li2S, thus improving their intrinsic activity.
Ge Incorporation to Stabilize Efficient Inorganic CsPbI3 Perovskite Solar Cells
Authors: Meng Fanqi , Yu Bingcheng , Zhang Qinghua , Cui Yuqi , Tan Shan , Shi Jiangjian , Gu Lin , Li Dongmei , Meng Qingbo , Nan Cewen 
Published: January 2022

AbstractAiming at stable CsPbI3 perovskite solar cells, Ge incorporated for the first time into DMAPbI3‐based precursor systems. Ge incorporation is found to be able to modify crystallization growth of CsPb1−xGexI3 films and reduce annealing temperature and treatment time by lowering CsPbI3 formation energy. The champion power conversion efficiency (PCE) of 19.52% is achieved with a certified PCE of 18.8%, which is the highest performance of CsPbI3 PSCs with alien element‐doping. In addition, in situ formation of GeO2 can passivate the grain boundary and surface defects, thus significantly improving the moisture resistance of the perovskite film and related devices. Excellent operational stability is achieved with no PCE degradation over 3000 h at a fixed bias voltage of 0.85 V under continuous white LED (6500 K) illumination and a nitrogen atmosphere. This work demonstrates that Ge‐incorporation is a promising way to stabilize CsPbI3 perovskite solar cells by simultaneously improving perovskite crystallinity and passivating the grain boundary and interfacial defects.
A truncating variant in the THOC6 gene with new findings in a patient with Beaulieu‐Boycott‐Innes syndrome
Authors: Kiraz Aslıhan , Tubaş Filiz , Seber Turgut 
Published: January 2022

AbstractBeaulieu‐Boycott‐Innes syndrome (BBIS; MIM#613680) is a rare, autosomal recessive neurodevelopmental genetic disorder associated with pathogenic variants in the THOC6 gene (*615403). Intellectual disability, dysmorphic facial features, developmental delay, structural cardiac and genitourinary anomalies, and dental caries are suggestive findings of the syndrome. Exome sequencing (ES) may facilitate the diagnosis of this syndrome, whose clinical features can be nonspecific. Here we report a BBIS patient with a homozygous truncating variant (NM_024339.5:c.299G>A; p.Trp100Ter) in the THOC6 gene, diagnosed by ES analysis. The patient's variant is novel and some features such as clivus dysplasia, occult spina bifida, tapered fingers, and upturned fleshy earlobes have not been reported in the literature before. This new case report will expand the knowledge of BBIS and provide more information about the genetic variants and phenotypic spectrum. Also, new cases with THOC6 variants will define the core clinical features and common phenotypes of the BBIS over time.
Plasma p‐tau231, p‐tau181, PET Biomarkers, and Cognitive Change in Older Adults
Authors: Meyer Pierre‐François , Ashton Nicholas J. , Karikari Thomas K. , Strikwerda‐Brown Cherie , Köbe Theresa , Gonneaud Julie , Pichet Binette Alexa , Ozlen Hazal , Yakoub Yara , Simrén Joel , Pannee Josef , Lantero‐Rodriguez Juan , Labonté Anne , Baker Suzanne L. , Schöll Michael , Vanmechelen Eugeen , Breitner John C. S. , Zetterberg Henrik , Blennow Kaj , Poirier Judes , Villeneuve Sylvia ,   Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer Disease (PREVENT‐AD) Research Group
Published: January 2022

ObjectiveThe objective of this study was to evaluate novel plasma p‐tau231 and p‐tau181, as well as Aβ40 and Aβ42 assays as indicators of tau and Aβ pathologies measured with positron emission tomography (PET), and their association with cognitive change, in cognitively unimpaired older adults.MethodsIn a cohort of 244 older adults at risk of Alzheimer's disease (AD) owing to a family history of AD dementia, we measured single molecule array (Simoa)‐based plasma tau biomarkers (p‐tau231 and p‐tau181), Aβ40 and Aβ42 with immunoprecipitation mass spectrometry, and Simoa neurofilament light (NfL). A subset of 129 participants underwent amyloid‐β (18F‐NAV4694) and tau (18F‐flortaucipir) PET assessments. We investigated plasma biomarker associations with Aβ and tau PET at the global and voxel level and tested plasma biomarker combinations for improved detection of Aβ‐PET positivity. We also investigated associations with 8‐year cognitive change.ResultsPlasma p‐tau biomarkers correlated with flortaucipir binding in medial temporal, parietal, and inferior temporal regions. P‐tau231 showed further associations in lateral parietal and occipital cortices. Plasma Aβ42/40 explained more variance in global Aβ‐PET binding than Aβ42 alone. P‐tau231 also showed strong and widespread associations with cortical Aβ‐PET binding. Combining Aβ42/40 with p‐tau231 or p‐tau181 allowed for good distinction between Aβ‐negative and ‐positive participants (area under the receiver operating characteristic curve [AUC] range = 0.81–0.86). Individuals with low plasma Aβ42/40 and high p‐tau experienced faster cognitive decline.InterpretationPlasma p‐tau231 showed more robust associations with PET biomarkers than p‐tau181 in presymptomatic individuals. The combination of p‐tau and Aβ42/40 biomarkers detected early AD pathology and cognitive decline. Such markers could be used as prescreening tools to reduce the cost of prevention trials. ANN NEUROL 2022;91:548–560
Extraordinary p–d Hybridization Interaction in Heterostructural Pd‐PdSe Nanosheets Boosts C−C Bond Cleavage of Ethylene Glycol Electrooxidation
Authors: Qin Yuchen , Zhang Wenlong , Wang Fengqi , Li JunJun , Ye Jinyu , Sheng Xia , Li Chenxi , Liang Xiaoyu , Liu Pei , Wang Xiaopeng , Zheng Xin , Ren Yunlai , Xu Cuilian , Zhang Zhicheng 
Published: January 2022

AbstractAdvanced electrocatalysts for complete oxidation of ethylene glycol (EG) in direct EG fuel cells are strongly desired owing to the higher energy efficiency. Herein, Pd‐PdSe heterostructural nanosheets (Pd‐PdSe HNSs) have been successfully fabricated via a one‐step approach. These Pd‐PdSe HNSs feature unique electronic and geometrical structures, in which unconventional p–d hybridization interactions and tensile strain effect co‐exist. Compared with commercial Pd/C and Pd NSs catalysts, Pd‐PdSe HNSs display 5.5 (6.6) and 2.5 (2.6) fold enhancement of specific (mass) activity for the EG oxidation reaction (EGOR). Especially, the optimum C1 pathway selectivity of Pd‐PdSe HNSs reaches 44.3 %, illustrating the superior C−C bond cleavage ability. Electrochemical in situ FTIR spectroscopy and theoretical calculations demonstrate that the extraordinary p–d hybridization interaction and tensile strain effect could effectively reduce the activation energy of C−C bond breaking and accelerate CO* oxidation, boosting the complete oxidation of EG and improving the catalytic performance.
Tumor‐Microenvironment‐Responsive Biodegradable Nanoagents Based on Lanthanide Nucleotide Self‐Assemblies toward Precise Cancer Therapy
Authors: Yang Yingjie , Liu Yan , Tu Datao , Chen Mingmao , Zhang Yunqin , Gao Hang , Chen Xueyuan 
Published: January 2022

AbstractStimuli‐responsive nanoagents, which simultaneously satisfy normal tissue clearance and tumor‐specific responsive treatment, are highly attractive for precise cancer theranostics. Herein, we develop a unique template‐induced self‐assembly strategy for the exquisitely controlled synthesis of self‐assembled lanthanide (Ln3+) nucleotide nanoparticles (LNNPs) with amorphous structure and tunable size from sub‐5 nm to 105 nm. By virtue of the low‐temperature (10 K) and high‐resolution spectroscopy, the local site symmetry of Ln3+ in LNNPs is unraveled for the first time. The proposed LNNPs are further demonstrated to possess the ability for highly efficient loading and tumor‐microenvironment‐responsive release of doxorubicin. Particularly, sub‐5 nm LNNPs not only exhibit excellent biocompatibility and predominant renal‐clearance performance, but also enable efficient tumor retention. These findings reveal the great potential of LNNPs as a new generation of therapeutic platform to overcome the dilemma between efficient therapy and long‐term toxicity of nanoagents for future clinical applications.
Identifying the seasonal characteristics of likely habitats for the Yangtze finless porpoise in Poyang Lake
Authors: Li Qiyue , Lai Geying , Liu Ying , Devlin Adam Thomas , Zhan Shupin , Wang Sheng 
Published: January 2022

Abstract

The Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis) has experienced significant decline and habitat degradation in recent decades. At present, nearly half of the total population inhabits Poyang Lake. The hydrological seasonality of the lake significantly influences porpoise habitat configuration, which brings problems for conservation in the delineation of reserve design and the management of human activities.
A hydrodynamic model was used to distinguish the different hydrological conditions between the flood and dry seasons. The MaxEnt model was used to investigate the major environmental variables affecting porpoise distribution and delineate likely habitats of the porpoise under different hydrological conditions. The effectiveness of the present nature reserve was evaluated based on these results.
Flow velocity and distance to fish spawning grounds were the primary variables influencing porpoise distribution during the dry season. Water depth, flow velocity and the distance to bank were the major variables during the flood season. The likely habitats were distributed discontinuously along the main channel during the dry season, with a total area of 112 km2. During the flood season, the habitats extended into the central areas of the lake and tributaries with a total area of 628 km2.
At present, the nature reserve covers 4% and 18% of the likely core habitats during dry and flood seasons. An ideal nature reserve should be designed as an integrative network with reference to the seasonality of likely habitat distribution and major environmental variables. The habitats in conditions of extreme low water should be strictly protected in the dry season.
Enhanced survey efforts, long‐term hydrodynamic modelling and species distribution modelling can greatly assist in understanding habitat configuration and changing processes for other freshwater cetaceans inhabiting river–lake systems. Future planning to improve protection should consider habitat characteristics under the shifting hydrological conditions caused by climate change or artificial flow alteration.
A framework for digital supply chains in the era of circular economy: Implications on environmental sustainability
Authors: Dwivedi Ashish , Paul Sanjoy Kumar 
Published: January 2022

AbstractIncreased attention to environmental sustainability has created pressures to adopt the circular economy (CE) principles. The transition toward CE requires system redesign and business process modification. Embracing disruptive technologies produces several benefits including improved productivity and resource utilization. Thus, organizations become eager to adopt and sustain digital supply chains (DSCs) in globally competitive markets. Additionally, the linkage between DSC with CE and the impact of DSC on organizational performances from the perspective of CE remain unexplored in previous studies. This study aims to develop a framework for DSC adoption from the perspective of CE. The present study recognizes the barriers through literature review and experts' opinions that must be eradicated to attain the objectives of DSCs. In this study, 19 potential barriers to DSCs were identified. A fuzzy best–worst method (BWM) was adopted to prioritize the identified barriers. Further, the study formulates strategies for integrating the CE with DSCs to overcome the barriers. A modified Total Interpretive Structure Model (m‐TISM) was developed to highlight the different levels of suggested strategies. This study contributes to the existing literature by analyzing the identified barriers to DSCs and suggesting overcoming strategies. The integrated methodology assists organizations to develop efficient and integrated strategic measures toward DSC adoption through the application of enhanced knowledge of CE and environmental sustainability. The findings reveal that the “lack of digital skills and facilities” is the most influential barrier in DSC development. Further, the findings indicate that financial and regulatory supports are the primary steps toward a digitalized economy.