bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abu al-Jaroud Ziyad Ibn al-Mundhir between Zaydiyyah and Ahl al-Hadith
Authors: ALMASAWA Alı 
Published: June 2022

ملخص :كثيرة هي القضايا الجدلية في المذهب الزيدي، بل إن المذهب الزيدي كفكرة وكمذهب يعتبر قضية جدلية بنفسه خصوصا عند المعاصرين، فالزيدية من حيث الفرق والملل انقسمت إلى عدة أقسام خصوصا عند متأخري زيدية اليمن، وتأتي فرقة الجارودية في رأس هذا الانقسام، والحديث عن زعيم هذه الفرقة هنا من نافذة الجرح والتعديل، والبحث يعرض مشهدين: الأول لعلماء الزيدية والثاني لأهل الحديث، ثم تأتي دراسة المشهدين، وطبيعة هذه المقالة نقدية وتحليلية لما تم عرضه في المشهدين حول زياد بن المنذر أبي الجارود، كما أن المنهج النقدي للرواة هنا هو منهج أهل الحديث، إذ أن الزيدية لا منهج لهم في فن علم الرجال كما تُبين هذه المقالة.
والغرض من هذه الدراسة بيان منهج أهل الحديث في التعامل مع الرواة المجروحين من خلال تعاملهم مع أبي الجارود، وتأتي أهمية دراسة شخصية المقالة من حيث فرقة الجارودية التي تُنسب إلى شخصية المقالة؛ فهي أكثر الفرق الزيدية انتشارا عن غيرها من الفرق، ويمثل أبو الجارود نقطة البداية للأفكار التي دخلت إلى المذهب الزيدي بعد موت زيد بن علي والذي يُنسب إليه المذهب الزيدي، وهذا المقال يجمع بين ما قيل من جرح وتعديل في أبي الجارود وبين واقع التعامل معه من قبل علماء هذا الفن، وتدرس المقالة أسانيد الأقوال التي تكلمت في شخصية المقالة مع بيان منهج التعامل مع مرويات أبي الجارود.
PUSAT SUMBER MUSIK DUNIA DI ISI SURAKARTA: PERAN, MASALAH, DAN KEBIJAKAN
Authors: Santosa S., 
Published: June 2022

Pusat Musik Dunia di ISI Surakarta memainkan peran penting dalam menyediakan informasi mengenaiÂ musik dan kegiatan-kegiatan masyarakat yang berhubungan dengan musik. Dengan beragam gaya danÂ aliran yang ada di dalam koleksinya, artikel ini bermaksud menyediakan informasi yang bisa digunakanuntuk memahami masyarakat dan proses budaya. Penggunanya, yang memiliki pendapat serta sudutÂ pandang yang berbeda, dapat membangun pemahaman yang lebih baik mengenai pertunjukan serta prosesproses masyarakat tempat pertunjukan digelar, entah itu di masa lalu maupun di masa kini. Denganpemahaman-pemahaman ini, mereka akan bisa menggunakannya untuk membangun gagasan-gagasanÂ untuk riset serta penciptaan seni pertunjukan.Kata kunci: pusat musik dunia, gaya, kebijakan, koleksi musik, persepsi.
SANGGIT DALAM PERTUNJUKAN WAYANG KULIT PURWA LAKON BANJARAN DASAMUKA SAJIAN PURBO ASMORO
Authors: Sudarwanto Agung 
Published: June 2022

Dalam artikel hasil riset ini berusaha memahami fenomena dalam lakonÂ Banjaran DasamukaÂ yang menggunakan metode diskriptif analitis. Data yang diperoleh selanjutnya diseleksi dan dianalisis menggunakan konsep ataupun teori terkait dengan Estetika Pedalangan dan dengan menggunakan penÂ­dekatan Ilmu Komunikasi serta Semiotika Teater untuk mengungkap kejelasan makna. Purbo Asmoro telah menyajikan bentuk struktur dramatik sajianÂ pakeliranÂ semalamÂ garapÂ yang berbeda dengan struktur dramatik sajianÂ pakeliranÂ tradisi semalam.Â SanggitÂ yang disajikannya mampu memenuhi fungsi teknis dan estetis sehingga menciptakan rasa penghayatan yang estetik. MaknaÂ sanggitÂ dalam lakonBanjaran DasamukaÂ menggambarkan perasaan senang, gembira, mencintai, dan penggambaran dari akibat yang ditimbulkan dari rasa senang yang berlebihan. Pesan yang disampaikannya sebagai sarana pembentukan karakter bangsa.Kata kunci: Kreatifitas, ceritera pertunjukan wayang Banjaran Dasamuka
ESTETIKA KARAWITAN BALI
Authors: Sukerta Pande Made 
Published: June 2022

Estetika adalah sebagai â€œrohâ€ dalam karya musik atau karawitan artinya sasaran atau obyek akhir dari sajian musik yang penilaiannya sangat subyektif dan tingkat atau kadar penilaiannya tergantung dari kemampuan maupun kepekaan penghayat. Demikian kadar atau kualitas estetika yang dihasilkan dari suatu karya karawitan tergantung dari kemampuan kesenimanan para seniman penyusun atau pencipta. Estetika dibentuk oleh berbagai faktor antara lain kemampuan individu dan karakter para seniman penciptanya termasuk lingkungan atau konteksnya. Barungan gamelan Bali jumlahnya sekitar 34 jenis barungan yang masing-masing mempunyai tungguhan, repertoar, fungsi, dan seniman pendukung serta estetika yang berbeda-beda. Ada dua sumber estetika, yaitu teks dan konteks. Teks adalah unsur-unsur yang mewujudkan karya, yaitutungguhan: bahan, jumlah,Â bentuk, pelarasan,Â Â tabuhan,Â interpretasi,Â Â rasa (rase), danÂ gaya.Â Konteks adalah unsur-unsur yang berada di luar teks,yaitupotensi kesenian, ungkapan seniman, nilai kehidupan masyarakatÂ pendukungnya.Â Pada artikelÂ ini pembahasan estetika memfokuskan pada teks yang dikaji dari aspek repertoar,Â tungguhan, dan teknikÂ tabuhan.Kata Kunci: estetika, teks, konteks
Pamona Language Reduplication
Authors: Idris Idris , Suputra Gusti Ketut Alit , Ali Ali , Uwu Charles Reinaldo 
Published: June 2022

This qualitative research aims to describe the form and the meaning of Pamona Language Reduplication. Data collection techniques were carried out through listening method and conversational method, using the listening-engagement technique, the free-talk listening technique, the documentation technique and the note-taking technique. The research was conducted in Tiu Village, East Pamona District, Poso Regency. The data obtained were in the form of written and oral data obtained through data collection techniques. Furthermore, the data were analyzed through equivalent distribution. The result shows that the form and the meaning of Pamona language reduplication are: (1) Reduplication of all words, (2) Partial reduplication, (3) Reduplication combined with affixes from the results of research that found the meaning of Pamona language reduplication, namely: (1 ) Stating the meaning of each other, (2) Stating the meaning of actions done repeatedly, (3) Stating the meaning of actions that are carried out without purpose, it is casual or it is just for fun.
Pemanfaatan Masker Limbah COVID-19 Sebagai Upaya Mengurangi Pencemaran Lingkungan
Authors: Fitria Hanin , Ahmad Tita Latifah , Rizaq Syaiful Umam 
Published: June 2022

Masker adalah salah satu jenis alat pelindung diri yang paling penting digunakan sebagai penghalang utama untuk melindungi dari virus yang menyebar melalui tetesan ini. Masker medis merupakan masker yang mudah ditemukan dan sekali pakai yang biasa digunakan oleh tenaga kesehatan yang bertugas. Masker medis berbentuk persegi panjang dan terdiri dari 3 atau 4 lapisan. Setiap lapisan terdiri dari serat lembut hingga sangat lembut. Karakteristik kinerjanya mengikuti serangkaian metode pengujian standar (ASTM F2100, EN 14683 atau setara) yang bertujuan untuk menyesuaikan filtrasi yang baik, ventilasi yang baik, dan ketahanan (opsional) terhadap penetrasi cairan. Â Mengenakan masker sudah menjadi kehidupan sehari-hari bagi banyak orang. Hal ini telah menyebabkan peningkatan yang signifikan dalam permintaan masker wajah sekali pakai di seluruh dunia. Masker wajah sekali pakai adalah salah satu jenis APD yang paling umum digunakan untuk mencegah infeksi virus. Namun, penanganan yang salah dari bahan-bahan ini mengancam lingkungan dengan bentuk-bentuk baru polusi plastik. Mengabaikan keseriusan masalah ini, sejumlah besar mikroplastik dapat dilepaskan ke tempat pembuangan sampah dan lingkungan laut, yang dapat memiliki implikasi serius bagi flora dan fauna. Oleh karena itu, penelitian ini memaparkan dua opsi untuk mendaur ulang limbah masker COVID-19. Selain itu, kami akan menjelaskan perencanaan produk dengan metode QFD.
Analisis Resapan Tanah Dengan Sistem Biopori Sebagai Alternatif Pengendalian Banjir
Authors: Nurzanah Wiwin 
Published: June 2022

Banjir merupakan masalah yang hampir setiap tahun melanda wilayah perkotaan maupun pedesaan. Banjir disebabkan karena tidak lancarnya saluran pembuangan air yang menyebabkan terjadinya luapan air, kurangnya kesadaran masyarakat untuk tidak membuang sampah ke aliran air, dan berkurangnya lahan sebagai area untuk resapan air. Karenanya dilakukan penelitian guna mengetahui perbandingan penyerapan air dengan penggunaan bantuan biopori dan tanpa menggunakanÂ biopori. Tujuan penelitian ini adalah untuk mengetahui besarnya debit banjir di jalan luku 1 Kwala Bekala, Medan Johor dan mengetahui besar laju infiltrasi tanah bisa atau tidaknya ditangani dengan biopori. Penelitian ini, akan mendeskripsikan solusi untuk mengurangi terjadinya banjir dengan cara penerapan biopori disekitar daerah yang rawan banjir. Ini salah satu solusi yang cukup ampuh dan simple dalam penangan banjir. Dari perhitungan jumlah resapanÂ biopori untuk kawasan Kwala Bekala Medan Johor tepatnya dijalan luku 1. Dibutuhkan 75 buah lubang biopori yang mendekati nilai Qbanjir Â sebesar 0,06 m3/dtk. Dan Dari hasil uji tanah di laboratorium untuk jenis tanah pada lokasi jalan luku 1 Kwala Bekala Medan Johor, memiliki tekstur tanah sandy loam (lempung berpasir) di kedalaman 30 cm dan sandy clay (tanah liat berpasir) dikedalaman 60 cm.
Ectogenesis and the Moral Status of the Fetus
Authors: Simkulet William 
Published: June 2022

Many people believe the morality of abortion stands or falls with the moral status of the fetus. Judith Jarvis Thomson’s violinist argument bypasses the question of fetal moral status; even if the fetus has a right to life, she argues the gestational mother has a right to disconnect herself from the fetus. However, should ectogenesis – a technology that would allow the fetus to develop outside the womb – become sufficiently advanced, the fetus would no longer need a gestational mother to live. Recently, Joona Räsänen has argued that parents have a right to secure the death of a fetus that has been removed from the mother’s body, and that this right might extend to infanticide. However, here I argue Räsänen’s position ignores the moral status of the fetus; if the fetus is morally comparable to beings like us, then of course parents lack a right to the death of their children. However, if the fetus is morally comparable to a tumor, then the right to kill it is philosophically uninteresting.
Mesenchymal Stromal Cells Combined With Elastin-Like Recombinamers Increase Angiogenesis In Vivo After Hindlimb Ischemia
Authors: Ibáñez-Fonseca Arturo , Rico Ana , Preciado Silvia , González-Pérez Fernando , Muntión Sandra , García-Briñón Jesús , García-Macías María-Carmen , Rodríguez-Cabello José Carlos , Pericacho Miguel , Alonso Matilde , Sánchez-Guijo Fermín 
Published: June 2022

Hindlimb ischemia is an unmet medical need, especially for those patients unable to undergo vascular surgery. Cellular therapy, mainly through mesenchymal stromal cell (MSC) administration, may be a potentially attractive approach in this setting. In the current work, we aimed to assess the potential of the combination of MSCs with a proangiogenic elastin-like recombinamer (ELR)–based hydrogel in a hindlimb ischemia murine model. Human bone marrow MSCs were isolated from four healthy donors, while ELR biomaterials were genetically engineered. Hindlimb ischemia was induced through ligation of the right femoral artery, and mice were intramuscularly injected with ELR biomaterial, 0.5 × 106 MSCs or the combination, and also compared to untreated animals. Tissue perfusion was monitored using laser Doppler perfusion imaging. Histological analysis of hindlimbs was performed after hematoxylin and eosin staining. Immunofluorescence with anti–human mitochondria antibody was used for human MSC detection, and the biomaterial was detected by elastin staining. To analyze the capillary density, immunostaining with an anti–CD31 antibody was performed. Our results show that the injection of MSCs significantly improves tissue reperfusion from day 7 (p = 0.0044) to day 21 (p = 0.0216), similar to the infusion of MSC + ELR (p = 0.0038, p = 0.0014), without significant differences between both groups. After histological evaluation, ELR hydrogels induced minimal inflammation in the injection sites, showing biocompatibility. MSCs persisted with the biomaterial after 21 days, both in vitro and in vivo. Finally, we observed a higher blood vessel density when mice were treated with MSCs compared to control (p&lt;0.0001), but this effect was maximized and significantly different to the remaining experimental conditions when mice were treated with the combination of MSCs and the ELR biomaterial (p &lt; 0.0001). In summary, the combination of an ELR-based hydrogel with MSCs may improve the angiogenic effects of both strategies on revascularization of ischemic tissues.
Identification of Small-Molecule Inhibitors for Osteosarcoma Targeted Therapy: Synchronizing In Silico, In Vitro, and In Vivo Analyses
Authors: Liu Juan , Yao Qi , Peng Yu , Dong Zhihong , Tang Lu , Su Xiaoyu , Liu Lishuang , Chen Cheng , Ramalingam Murugan , Cheng Lijia 
Published: June 2022

Objective: The study aimed to explore a new approach for the treatment of osteosarcoma through combining biomaterials with next-generation small molecule–based targeted therapy.Methods: The model of osteosarcoma was established by 4-hydroxyaminoquinoline 1-oxide (4-HAQO) in mice while the collagen-thermosensitive hydrogel–calcium phosphate (CTC) biocomposites were prepared, and the small molecule inhibitors were virtually screened and synthesized. Then, for the osteosarcoma cell line, MG-63 cells were used to validate our bioinformatic findings in vitro, and the mouse osteosarcoma models were treated by combing CTC composites and small-molecule inhibitors after debridement.Results: Five compounds, namely, ZINC150338698, ZINC14768621, ZINC4217203, ZINC169291448, and ZINC85537017, were found in the ZINK database. Finally, ZINC150338698 was selected for chemical synthesis and experimental verification. The results of the MTT assay and Hoechst staining showed that the small-molecule inhibitor ZINC150338698 could significantly induce MG-63 cell death. Furthermore, CTC composites and ZINC150338698 could repair the bone defects well after the debridement of osteosarcoma. In addition, the biomaterials and small-molecule inhibitors have good biocompatibility and biosafety.Conclusion: Our findings not only offer systems biology approach-based drug target identification but also provide new clues for developing novel treatment methods for future osteosarcoma research.
Design, Synthesis, and Evaluation of Anticonvulsant Activities of New Triazolopyrimidine Derivatives
Authors: Song Mingxia , Zhao Wennan , Zhu Yangnv , Liu Wenli , Deng Xianqing , Huang Yushan 
Published: June 2022

Epilepsy, a severe brain disease affecting a large population, is treated mainly by antiepileptic drugs (AEDs). However, toxicity, intolerance, and low efficiency of the available AEDs have prompted the continual attempts in the discovery of new AEDs. In this study, we discovered a skeleton of triazolopyrimidine for the development of new AEDs. The design, synthesis, in vivo anticonvulsant activity evaluation of triazolopyrimidines (3a–3i and 6a–6e), and pyrazolopyrimidines (4a–4i) are reported. We found that most triazolopyrimidines showed anticonvulsive activity in the maximal electroshock (MES) and pentetrazol (PTZ)-induced seizure models. On the contrary, pyrazolopyrimidines (4a–4i) showed weak or no protective effects. Among the tested derivatives, compound 6d, holding a median effective dose (ED50) of 15.8 and 14.1 mg/kg against MES and PTZ-induced seizures, respectively, was found to be the most potent one. Moreover, the protection index (PI) value of 6d was significantly higher than that of the available AEDs such as valproate, carbamazepine, and diazepam. The antiepileptic efficacy of compound 6d was also observed in the 3-mercaptopropionic acid and bicuculline-induced seizure models. Antagonistic effects of flumazenil and 3-MP for the anticonvulsive activity of 6d and also the radioligand-binding assay confirmed the involvement of GABA receptors, at least benzodiazepine (BZD) receptor, in the anticonvulsant activity of compound 6d. The docking study of compounds 4e and 6d with GABAA receptor confirmed and explained their affinity to the BZD receptors.
Circulating Small Extracellular Vesicles Profiling and Thrombin Generation as Potential Markers of Thrombotic Risk in Glioma Patients
Authors: Melnichnikova Olga , Zhilenkova Yulia , Sirotkina Olga , Zolotova Ekaterina , Pishchulov Konstantin , Tastanbekov Malik , Paltsev Artem , Simakova Maria 
Published: June 2022

IntroductionPatients with glioma (GM) are at a high risk of venous thromboembolism (VTE). The role of microvesiculation in the cancer-associated thrombosis mechanisms has been previously demonstrated. This study aimed to evaluate the relative abundance of extracellular vesicles (EVs) and thrombin generation (TG) in combination with standard laboratory tests in patients with newly diagnosed GM as potential prognostic markers in VTE.Materials and MethodsIn the present study, 11 patients with newly diagnosed GM and 10 healthy volunteers were analyzed. EVs were counted and their cellular origin was determined (CytoFlex B4-R2-V2, Beckman Coulter, United States), as well as thrombin generation test (TGT) (Diagnostica Stago SAS, France) was performed.ResultsIn patients with GM, the relative abundance of the CD41 + EVs (platelet-derived)—and CD105 + EVs (endothelial-derived) was significantly higher than in the control group (44.3 [40.5; 52.4] vs. 27.2 [22.9; 31.0]%, p = 0.002, and 5.4 [4.8; 7.8] vs. 1.9 [1.5; 2.8]%, p = 0.0003, respectively). The D-dimer level was higher in patients with GM compared with the control group (0.46 [0.38; 1.85] vs. 0.36 [0.27; 0.40] μg/ml FEU, p = 0.03, respectively). There was a trend toward an increase in the peak thrombin and velocity index (VI) in the GM group (p = 0.06). During the follow-up period, two patients (18%) developed thrombosis, had tumor sizes of more than 5 cm, thrombocytopenia, increased VI, and D-dimer.ConclusionAnalysis of platelet-derived EVs, platelet count, and TGT in combination with D-dimer assessment could improve the stratification of patients prone to VTE, which needs to be confirmed in a larger sample.
Fatty Liver Index Independently Predicts All-Cause Mortality in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis but No Substantial Liver Disease
Authors: Park Pil Gyu , Pyo Jung Yoon , Ahn Sung Soo , Choi Hyun Joon , Song Jason Jungsik , Park Yong-Beom , Huh Ji Hye , Lee Sang-Won 
Published: June 2022

BackgroundThis study investigated whether the fatty liver index (FLI) could predict all-cause mortality and cerebrovascular accident (CVA) during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) without substantial liver disease.MethodsThe medical records of 75 AAV patients with AAV were retrospectively reviewed. An equation for the FLI is as follows: FLI = (e0.953×loge(triglycerides)+0.139×BMI+0.718×loge(GGT)+0.053×waistcircumference–15.745)/(1 + e0.953×loge(triglycerides)+0.139×BMI+0.718×loge(GGT)+0.053×waistcircumference–15.745) × 100. The cut-offs of the FLI were obtained using the receiver operator characteristic (ROC) curve analysis.ResultsThe mean age at AAV diagnosis was 59.1 years and 42.7% were male. Eight patients (10.7%) died and 8 patients had CVA during follow-up. When the cut-offs of the FLI for all-cause mortality and CVA were set as the FLI ≥ 33.59 and the FLI ≥ 32.31, AAV patients with the FLI over each cut-off exhibited a higher risk for all-cause mortality or CVA than those without (RR 8.633 and 8.129), respectively. In addition, AAV patients with the FLI over each cut-off exhibited a significantly lower cumulative patients’ survival rate or CVA-free survival rate than those without, respectively. In the multivariable Cox analysis, only the FLI ≥ 33.59 at AAV diagnosis was an independent predictor of all-cause mortality during follow-up in AAV patients (HR 10.448).ConclusionThe FLI at AAV diagnosis can be a potential independent predictor of all-cause mortality and CVA during follow-up in AAV patients. We suggest that physicians measure the FLI at AAV diagnosis and pay more attention to those with a high FLI value for prevention of future mortality and CVA.
Ultra-Deep Dolomite Reservoir Quality Classification and its Effect on Acid-Fracturing Based on Natural Fracture Activity Analysis: A Case Study of the Cambrian Subsalt Reservoir in Northern Uplift of Tarim Basin
Authors: Yin Guoqing , Zhang Hui , Xin Yi , Zhang Wei , Wu Xingneng , Liang Jingrui , Lai Shujun 
Published: June 2022

Taking the &gt;8,000 m buried Cambrian subsalt dolomite reservoir in the northern uplift of the Tarim Basin as an example, this study used imaging logging, cores, outcrops, and other data to identify natural fractures and obtain parameters of natural fractures, including strike, azimuth, width, length, and apparent porosity, and clarified the characteristics of natural fractures in the well section. Based on the logging data, wellbore rock mechanics, in situ stress, and elastic parameters were established. The analysis of the mechanical characteristics of natural fractures was carried out to find out the shear stress, normal stress, and their ratio of each natural fracture in the reservoir section. Combined with the stress value of each fracture, the quantitative characterization parameter Fractures Geomechanical Activity Index of the mechanical characteristics of natural fractures is established. Combined with the petrophysical parameters of natural fractures, the evaluation model of the quality index of the reservoir containing the natural fractures is established. According to the classification of reservoir quality, combined with the petrophysical properties of the reservoir section, the optimization of the acid-fracturing scheme and injection pressure can be carried out in order to increase the production after acid-fracturing. In this study, the quality of the reservoir with natural fractures is divided into three categories: the QRCF of a Class I reservoir is 0.6∼1, of Class II reservoir is 0.3∼0.6, and of Class III reservoir is less than 0.3. The application of Well L1 and other wells shows that there are great differences in the development of natural fractures at different depths of the Cambrian subsalt dolomite reservoir so as to QRCF. The Class I reservoir is easy for acid-fracturing to achieve high performance. The Class II reservoir needs large-scale acid-fracturing, and the Class III reservoir cannot be acid-fractured under the current methods. The research results provide a reference for the classification of the fracture mechanical activity of an ultra-deep Cambrian subsalt dolomite reservoir and the optimization of acid-fracturing treatment parameters of similar reservoirs.