bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloid-derived suppressor cells in hematologic malignancies: two sides of the same coin
Authors: Yu Shunjie , Ren Xiaotong , Li Lijuan 
Published: July 2022

AbstractMyeloid-derived suppressor cells (MDSCs) are a heterogeneous population of bone marrow cells originating from immature myeloid cells. They exert potent immunosuppressive activity and are closely associated with the development of various diseases such as malignancies, infections, and inflammation. In malignant tumors, MDSCs, one of the most dominant cellular components comprising the tumor microenvironment, play a crucial role in tumor growth, drug resistance, recurrence, and immune escape. Although the role of MDSCs in solid tumors is currently being extensively studied, little is known about their role in hematologic malignancies. In this review, we comprehensively summarized and reviewed the different roles of MDSCs in hematologic malignancies and hematopoietic stem cell transplantation, and finally discussed current targeted therapeutic strategies.Affiliation: Kindly check and confirm the processed affiliations are correct. Amend if any.correct
Regional landscape planning for the innovation of urban planning. Municipal implementation of the city-country pact in Apulia
Authors: Calace Francesca , Paparusso Olga Giovanna 
Published: July 2022

AbstractThe adoption of the European Landscape Convention (ELC) has wrought a profound evolution in the landscape planning discipline, contributing to the integration of the landscape into planning policy. This paper explores the operative significance of including the landscape dimension in local urban planning policies. Adopting an inter-scalar approach, the research analyses the renewal of local urban planning in light of the innovations introduced by the Apulia Regional Landscape Plan (PPTR), an exemplary case of ELC implementation in Italy. One of the spatial strategies indicated in the PPTR provides valuable insights into the complex relationships between the city and the countryside. That strategy, the City-Country Pact, interacts with urban transformations and, as a result, with municipal planning. The paper utilises PPTR indicators to explore how some Apulian municipalities interpret and implement the City-Country Pact. A comparative analysis of case studies outlines the approaches and conditions by which urban planning can effectively renew itself through the ELC landscape approach, influencing plan philosophy, regulations and practices. The paper also points out the current limitations of such processes.
COVID-19 epidemic lockdown-induced changes of cereals and animal protein foods consumption of Iran population: the first nationwide survey
Authors: Nikooyeh Bahareh , Rabiei Samira , Amini Maryam , Ghodsi Delaram , Rasekhi Hamid , Doustmohammadian Azam , Abdollahi Zahra , Minaie Mina , Sadeghi Farzaneh , Neyestani Tirang R. 
Published: July 2022

Abstract
Background
The COVID-19 epidemic has affected diverse issues of life including economy, health and nutrition. This nationwide study was conducted to evaluate the effects of the epidemic lockdown-induced socio-economic changes on animal source proteins and cereals intakes of Iran population for the first time.

Methods
This was a cross-sectional descriptive-analytical study using a web-based electronic self-administered questionnaire. A questionnaire was designed with the aim of detecting any changes in the dietary pattern of the Iranian household following coronavirus epidemic.

Results
A total of 21,290 households participated in the study. Approximately 33%, 24%, 14.2% and 7% of the households had decreased the weekly consumption of red meat, white meat, eggs and rice/bread, respectively, following COVID-19 epidemic. The results of ordered logistic regression showed that the female-headed households, as compared with male-headed ones, were 30% more likely to decrease their weekly consumption of white meat (OR = 1.3, 95% CI: 1.1–1.5). About 8.6% of the households had reduced all three major dietary sources of animal protein. Close to half of the households (46.9%) who decreased their intake of the animal protein sources had increased their intake of rice or bread, too. The major reasons for these changes were decrease of income and job loss.

Conclusion
In conclusion, animal protein food consumption decreased during epidemic lockdown but the amounts of rice and bread, as the major sources of dietary energy, have increased. These changes, if persist long enough, can seriously affect micronutrient status of the whole population. Early nutritional interventions for needy families are warranted.
Scoping review of 30 years of suicide prevention in university students around the world: efficacy, effectiveness, and cost-effectiveness
Authors: Cecchin Hareli Fernanda Garcia , Murta Sheila Giardini , de Macedo Etiene Oliveira Silva , Moore Rafael Alberto 
Published: July 2022

AbstractA scoping review of systematic reviews was carried out to identify evidence of efficacy, effectiveness, and cost-effectiveness of universal and selective suicide prevention programs among university students worldwide. Five databases were reviewed using terms in English, Spanish, and Portuguese. The following were the inclusion criteria: systematic review or meta-analysis or meta-synthesis, suicide prevention in college students, evaluation of the efficacy, effectiveness and/or cost-effectiveness of interventions, and peer-reviewed studies. The quality of reviews was assessed. The field of study features three decades of publication in high-income countries. The strategy used, the components of the program, and the target audience to which they are delivered interfere with efficacy. In the psychoeducation strategy, the experiential and didactic components are more efficacious in the knowledge about suicide. And the motivational enhancement component promotes greater self-efficacy in suicide prevention. Programs that take a multimodal approach are effective in increasing short-term attitudes related to suicide and reducing rates of completed suicide. The gatekeeper strategy delivered to peer counselors is the most effective one in the outcomes, including short-term and long-term knowledge about suicide and its prevention and self-efficacy in suicide prevention. A greater number of evaluated studies of gatekeeper interventions were identified, indicating a trend in this research field. No review addressed the effects on subgroups that were classified based on sex, racial or sexual minorities, and special (indigenous) populations. Only one study addressed cost-effectiveness, pointing out that the psychoeducation and gatekeeper strategies have relevant net benefit rates, but the gatekeeper strategy has a higher cost–benefit ratio compared to the psychoeducation strategy. The findings indicate that psychoeducation and gatekeeper interventions tend to be more efficacious when they combine education and skills training to intervene in suicidal behavior. The components of the intervention and the target audience to which it is delivered influence efficacy. Multimodal interventions evaluate completed suicide outcomes, but require greater implementation efforts, in terms of human and financial resources and more time for the evaluation.
Experiences of physiotherapists regarding a standard set of measurement instruments to improve quality of care for patients with chronic obstructive pulmonary disease: a mixed methods study
Authors: Verburg Arie C. , Zincken Jessica , Kiers Henri , van Dulmen Simone A. , van der Wees Philip J. 
Published: July 2022

Abstract
Rationale
The quality of physiotherapy care for patients with chronic obstructive pulmonary disease (COPD) can be improved by comparing outcomes of care in practice.

Aim
To evaluate the experiences of physiotherapists implementing a standard set of measurement instruments to measure outcomes and improve the quality of care for patients with COPD.

Methods
This sequential explanatory mixed methods study was performed in two parts. In the quantitative part, a survey of 199 physiotherapists was conducted to evaluate their attitudes and knowledge, as well as the influence of contextual factors (i.e., practice policy and support from colleagues), in the implementation of the standard measurement set. In the qualitative part, 11 physiotherapists participated in individual interviews to elucidate their experiences using a thematical framework.

Results
The survey showed that, on average, 68.4% of the physiotherapists reported having a positive attitude about using the standard set, 85.0% felt they had sufficient knowledge of the measurement instruments, and 84.7% felt supported by practice policy and colleagues. In total, 80.3% of physiotherapists thought the standard set had added value in clinical practice, and 90.3% indicated that the measurement instruments can be valuable for evaluating treatment outcomes. The physiotherapists mentioned several barriers, such as lack of time and the unavailability of the entire standard set of measurement instruments in their practice. Moreover, the physiotherapists indicated that the measurement instruments have added value in providing transparency to policymakers through the anonymized publication of outcomes.

Conclusion
Physiotherapists support the use of the standard set of measurement instruments to improve the quality of physiotherapy treatment for patients with COPD.
Comparative study on pathological changes in sheep and goats experimentally infected with Haemonchus Contortus
Authors: Abosse Jirata Shiferaw , Terefe Getachew , Teshale Bethlehem Mesfin 
Published: July 2022

AbstractBackgroundThe parasites causes localized and generalized infections to the host depends on the parasite attachment organs, depth of penetration, site of location and worm burdens.MethodsThe experimental study was done between December, 2019 and April, 2020 in the fly-proof experimental animal facility located in the premise of the College of Veterinary Medicine and Agriculture at Bishoftu, Ethiopia. A total of 14 male goat (G1 and G2) and 14 male sheep (G3 and G4) were allotted in to four equal groups. Single dose of 10,000 of infective larvae ofHaemonchus contortus(L3) was orally administered to each animal in G1 and G3. Parameters such as body weight, PCV, haemoglobin, worm count, serum total protein, serum albumin, alkaline phosphatase and aspartate aminotransferase were measured. Moreover, histopathological sections were stained and examined for general changes as well as for changes in specific cells such as tissue eosinophilia and parietal cell population.ResultsThe findings show that 1) All infected sheep and goats developed the infection with higher mean worm burden in goats (5590) than sheep (2887) and the difference was significant (P < 0.05); 2) All infected sheep and goats exhibited a progressive anaemia; the level being more severe in goats than in sheep (P < 0.05) with mean PCVs of 13 and 18.6% respectively; 3) While body weight gain was minimal in sheep, goats have lost significant weight compared to pre-infection levels, to control animals or in relation to infected sheep (P < 0.05); 4) analysis of biochemical changes revealed marked reduction in serum total protein and albumin which was much more significant in goats than in sheep (P < 0.05); 5) the abomasum of infected sheep and goats have shown thickening, nodule development, eosinophilic infiltration and damage to parietal cells. Tissue eosinophilia was more prominent in sheep while parietal cell loss was severe in goats.ConclusionIn conclusion, goats under experimental infection and similar management condition with sheep develop much more severe infection and associated pathology compared to sheep and hence deserve special attention.
An analysis of the recent fire regimes in the Angolan catchment of the Okavango Delta, Central Africa
Authors: van Wilgen Brian W. , de Klerk Helen M. , Stellmes Marion , Archibald Sally 
Published: July 2022

Abstract
Background
This paper presents an analysis of fire regimes in the poorly studied Angolan catchment of the Okavango Delta in Botswana. We used MODIS data to examine the frequency and seasonality of fires over 20 years (from 2000 to 2020) in three dominant vegetation types (miombo woodlands, open woodlands and grasslands, and short closed to open bushlands), and in areas where people were present, and where they were absent.

Results
The median fire return intervals for both open woodlands and grasslands and short bushlands were relatively short (1.9 and 2.2 years respectively). In miombo woodlands, fires were less frequent (median return periods of 4.5 years). Human population density had no discernible effect on the fire return intervals, but about 14% of the miombo woodlands experienced no fires over 20 years. Ongoing shifting cultivation within miombo woodlands has led to structural changes and the introduction of fire into this vegetation type where fires were rare or absent in the past. About 12% of the miombo did not burn during the period examined where people were present, whereas close to 20% of the sites remained unburnt where people were absent. This suggests that people did not change the fire return interval in any of the vegetation types studied, but that they altered the amount of the landscape that is flammable in miombo vegetation. Fires occurred between June and September, with a peak in the late dry season (August and September).

Conclusions
Historical research indicates that late dry-season fires are detrimental to miombo woodlands, and our analysis suggests that degradation in parts of the catchment has led to the introduction of fire to this previously fire-free and fire-sensitive vegetation type. Deforestation of miombo woodlands, and the consequent introduction of fire, is a cause for concern with respect to the ecological stability of the Okavango Delta. Managers should therefore aim to protect the remaining closed-canopy miombo stands from further clearing and to attempt to shift the timing of burns to the early dry season to reduce their intensity.
Anticancer effects of metformin in experimental animal models of different types of cancer: a systematic review and meta-analysis
Authors: Zhang Fan , Han Shuai , Song Weijie 
Published: July 2022

AbstractTo systematically evaluate the effects of metformin on tumors in experimental animal models of different types of cancer. Pubmed, Embase, Cochrane, and Web of Science databases were searched for studies on metformin used in various experimental animal tumor models from 2008 to 2022. Meta-analysis was performed using STATA 16.0 software after screening literature extraction data and methodological quality evaluation by inclusion and exclusion criteria. A total of 24 studies with 1108 model animals were included. Meta-analysis results showed that this study used meta-analysis for quantitative synthesis of study results and found that tumor model animals of different species showed different degrees of reduction in tumor volume, weight, and number after metformin intervention.
Ultrasound-guided fine needle aspiration versus non-aspiration techniques in the evaluation of solid thyroid nodules
Authors: Heidar Mustafa Al-Hassan Abdou , Abd El Aziz Mohammad Ali , Mansour Mohamed G. , Farid Mostafa , Elsayed Hussein 
Published: July 2022

Abstract
Background
Comparison between the Fine Needle Non-Aspiration Cytology (FNNAC) and Fine Needle Aspiration Cytology (FNAC) in acquiring ultrasound-guided fine needle cytology (FNC) samples from solid thyroid nodules to determine the better technique, hence improving the sample quality aiming to decrease the number of unnecessary thyroidectomy operations.

Results
Prospective study showed statistically significant increase in cellular yield, preservation of cellular architecture and decrease in cellular trauma along with statistically significant increase in total sample quality with FNNAC (P value = 0.32, 0.004, 0.011, 0.21 respectively), and statistically insignificant difference in background blood in the sample (P value = 0.8).
Regarding sample convenience, FNNAC was found to be more convenient for both the patient (syringe is not seen by the patient reducing discomfort) and for the operator (better handling of the needle and fewer maneuvres).

Conclusions
FNC is an approved sensitive and cost-effective method to evaluate thyroid nodules, FNNAC technique was found to be more convenient for both the patient and the operator with statistically significant improvement in total sample quality compared to FNAC.
Aerosol boxes for airway management in coronavirus disease patients: a clinical retrospective study in Mexico
Authors: Duarte-Medrano Gilberto , Sorbello Massimiliano , Susunaga-Hope Rafael Renato , Fuentes-Castro Paula Ivette , Avila-OrtIz Beatriz C. , Velasco-Godinez Aida Paola , Contreras-Garcia Wendy Y. , Pineda-Castillo Miguel Alejandro , Urdaneta Felipe , Téllez-Ávila Félix Ignacio 
Published: July 2022

Abstract
Introduction
Significant concerns raise for the healthcare workers involved in airway management of patients diagnosed with coronavirus 2019 disease (COVID-19).
Due to shortages of personal protective equipment (PPE), barrier enclosure systems such as aerosol box (AB) have been proposed worldwide. The aim of this study was to evaluate our experience using AB as protective equipment in patients with COVID-19 in a third-level center in Mexico.

Methods
A retrospective study of COVID-19 patients requiring airway management using an AB in the Hospital Central Sur de Alta Especialidad de Pemex in Mexico City from March 1 to June 1, 2020. Antropometric data, pre-intubation vital signs, and laboratory tests were recorded; the primary endpoints were intubation success rate and complications associated with AB and patients’ mortality. As a secondary endpoint, AB subjective evaluation was explored by administering a survey after airway management procedures.

Results
Thirty-nine patients for a total of 40 intubations were documented. Thirty-one (77.5%) were men, with a mean age of 61.65 years; successful intubation occurred in 39 (97.55%) of the procedures, and AB was used in 36 (90%) of intubations, with success in 28 (70.0%); A Cormack-Lehane grade 3 view was recorded in 18 patients (46.2%), and during the procedure, the AB had to be removed in 8 (22.2%) cases, with migration documented in 91.6% of cases. The 30-day mortality was 48.71%, with 23.0% of patients discharged. 83.3% of surveyed anesthesiologists reported significant limitations in manipulating airway devices with AB used.

Conclusion
Our data indicate that in clinical practice, the use of AB may hinder airway management and decrease the intubation success rate and may also result in patients’ injury. Further studies are necessary to validate the use of AB in clinical practice, and they should not replace certified PPE.
Long-Term Effects of Local-Area New Deal Work Relief in Childhood on Educational, Economic, and Health Outcomes Over the Life Course: Evidence From the Wisconsin Longitudinal Study
Authors: Modrek Sepideh , Roberts Evan , Warren John Robert , Rehkopf David 
Published: July 2022

Abstract
The economic characteristics of one's childhood neighborhood have been found to determine long-term well-being. Policies enacted during childhood may change neighborhood trajectories and thus impact long-term outcomes for children. We use individual-level data from the Wisconsin Longitudinal Study to examine the enduring consequences of childhood exposure to local-area New Deal emergency employment work-relief activity. Our outcomes include adolescent cognition, educational attainment, midlife income, health behaviors, late-life cognition, and mortality. We find that children (ages 0–3) living in neighborhoods with moderate work-relief activity in 1940 had higher adolescent IQ scores, had higher class rank, and were more likely to obtain at least a bachelor's degree. We find enduring benefits for midlife income and late-life cognition for males who grew up in areas with a moderate amount of work relief. We find mixed results for males who grew up in the most disadvantaged areas with the highest levels of work-relief activity. These children had similar educational outcomes as those in the most advantaged districts with the lowest work-relief activity but had higher adult smoking rates. Our findings provide some of the first evidence of the long-term consequences of New Deal policies on children's long-term life course outcomes.
Supporting Teachers’ Implementation of Classroom-Based Physical Activity
Authors: Turner Lindsey , Calvert Hannah G. , Carlson Jordan A. 
Published: July 2022

ABSTRACT
Research exploring factors related to teachers’ implementation of classroom-based physical activity (CBPA) has increased in recent years. This article highlights key findings from the literature about the implementation and maintenance of CBPA by classroom teachers. The authors provide an overview of the literature examining CBPA implementation from an implementation science perspective. Topics addressed include methods for measuring implementation, characteristics of CBPA resources, and predictors of teachers’ implementation of CBPA. Findings from the narrative review are presented in tandem with insights from the authors’ work during a grant-funded project examining strategies to improve CBPA implementation in elementary schools. Many off-the-shelf resources for CBPA implementation exist, with varying degrees of implementation support. Studies have used a variety of methods to measure implementation, mostly focused on teacher self-report. Few studies have provided evidence regarding long-term use of CBPA, but those that do report decreased implementation rates over time. A robust body of research examining CBPA implementation facilitators and barriers shows that organizational-level support from district and school administrators is crucial for successful implementation. Leadership buy-in is crucial for the implementation of policies and practices in schools, such as CBPA initiatives. Approaches that are embedded within school systems, such as communities of practice and coaching from school champions, have potential for improving implementation. Disseminating CBPA resources and providing information about the importance of school and district leadership are suggested for more widespread implementation. Future work would benefit from the use of evidence-based implementation science frameworks to ensure that interventions are designed to maximize implementation at the classroom level.
XVII-wieczna Anglia w relacji gdańszczanina Nathana Schrödera
Authors: Nortowska Paulina 
Published: July 2022

17TH-CENTURY ENGLAND IN THE RELATIONSHIP OF NATHAN SCHRÖDER FROM GDAŃSK
The aim of this article is to present Nathan Schröder’s voyage to England as described in his travel diary. A citizen of Gdansk, Schröder embarked on an educational and cognitive journey to England in the seventeenth century. This article analyses the diary to recreate Schröder’s ideas of the country as well as his actual experiences traveling throughout it. In addition to the facts and objective observations he recorded, Schröder’s journal contains his impressions, feelings, judgments and subjective opinions. The author of the diary chooses the places he deemed worthy of seeing, but also interprets and presents the reality of his visit to England as he experienced it.