bluuebunny/crossref_metadata_2025_split huggingface dataset:
The subfornical organ regulates acidosis‐evoked fear by engaging microglial acid‐sensor TDAG8 and forebrain neurocircuits in male mice
Authors: Winter Andrew , McMurray Katherine M. J. , Ahlbrand Rebecca , Allgire Emily , Shukla Sachi , Jones James , Sah Renu 
Published: May 2022

AbstractAn important role of pH homeostasis has been suggested in the physiology of panic disorder, with acidosis as an interoceptive trigger leading to fear and panic. Identification of novel mechanisms that can translate acidosis into fear will promote a better understanding of panic physiology. The current study explores a role of the subfornical organ (SFO), a blood–brain barrier compromised brain area, in translating acidosis to fear‐relevant behaviors. We performed SFO‐targeted acidification in male, wild‐type mice and mice lacking microglial acid‐sensing G protein–coupled receptor—T‐cell death‐associated gene 8 (TDAG8). Localized SFO acidification evoked significant freezing and reduced exploration that was dependent on the presence of acid‐sensor TDAG8. Acidosis promoted the activation of SFO microglia and neurons that were absent in TDAG8‐deficient mice. The assessment of regional neuronal activation in wild‐type and TDAG8‐deficient mice following SFO acidification revealed significant acidosis and genotype‐dependent alterations in the hypothalamus, amygdala, prefrontal cortex, and periaqueductal gray nuclei. Furthermore, mapping of interregional co‐activation patterns revealed that SFO acidosis promoted positive hypothalamic‐cortex associations and desynchronized SFO‐cortex and amygdala‐cortex associations, suggesting an interplay of homeostatic and fear regulatory areas. Importantly, these alterations were not evident in TDAG8‐deficient mice. Overall, our data support a regulatory role of subfornical organ microglial acid sensing in acidosis‐evoked fear, highlighting a centralized role of blood–brain barrier compromised nodes in interoceptive sensing and behavioral regulation. Identification of pathways by which humoral information can modulate fear behavior is relevant to panic disorder, where aberrant interoceptive signaling has been reported.
A Raman spectroscopic study of the pyrolysis of lactose and tannins
Authors: Brehm Simon , Kraus Jakob , Himcinschi Cameliu , Kortus Jens 
Published: May 2022

AbstractLactose and tannin are eco‐friendly alternatives to commonly used binders for carbon‐bonded alumina filters that are applied in steel melt filtration. The investigation of binder pyrolysis is a contribution to understand the production process of these filters. In this work, lactose and the tannins gallic acid, ellagic acid, and tannic acid were investigated by Raman spectroscopy. The tannins were measured in situ in an argon‐filled heating chamber. The transformation of the tannin molecules to a system of amorphous disordered carbon could be observed in the Raman spectra. In addition, the condensed pyrolysis products of the tannins were measured and identified. The Raman spectra were supported by peak positions calculated with density functional theory.
MFAP2 aggravates tumor progression through activating FOXM1/β‐catenin‐mediated glycolysis in ovarian cancer
Authors: Zhao Ling‐Qin , Sun Wei , Zhang Ping , Gao Wen , Fang Chen‐Yan , Zheng Ai‐Wen 
Published: May 2022

AbstractOvarian cancer is one of the most common gynecological tumors that seriously endanger the health and quality of life of women. Microfibril‐associated protein 2 (MFAP2) has been demonstrated to play crucial roles in the development of multiple tumors. However, the function of MFAP2 in ovarian cancer remains unclear. In this study, we found that MFAP2 was upregulated in ovarian cancer and cells and was positively correlated with FOXM1 and glycolysis‐related genes. The results of Cell Count Kit‐8, colony formation, and flow cytometry assays indicated that MFAP2 promoted cell proliferation. In addition, MFAP2 promotes cell proliferation, glucose uptake, lactate production; increases ATP levels, extracellular acidification ratio, and oxygen consumption ratio in ovarian cancer cells and increases the expression of glycolytic proteins. Further mechanistic analysis suggests that MFAP2 promotes FOXM1/β‐catenin‐mediated glycolysis signaling in ovarian cancer cells. Knockdown of MFAP2 inhibits ovarian cancer xenograft tumor growth and expression of Ki‐67, MFAP2, FOXM1, GLUT1, HK2, and β‐catenin in mice. In conclusion, MFAP2 promotes cell proliferation and glycolysis by modulating the FOXM1/β‐catenin signaling pathway in ovarian cancer, which may offer a fresh insight into the treatment of ovarian cancer in the glycolysis pathway.
Tribological performance optimization and synergistic lubrication evolution of Pb‐free FeS/Cu–Bi composites
Authors: Liu Cong , Yin Yanguo , Li Congmin , Xu Ming , Li Rong Rong , Chen Qi 
Published: May 2022

AbstractThe tribological properties of Pb‐free FeS/Cu–Bi (FCB) self‐lubricating composites were optimised with the Taguchi method. The effects of lubricant content and ball milling time on the anti‐friction and wear resistance of FCB composites were investigated. Then the evolution of the friction interface was observed through interrupted microscopy measurement to reveal its synergistic lubrication mechanism. The results showed that the primary and secondary factors that affected the anti‐friction and wear resistance of the FCB composites were FeS content, Bi content and ball milling time. The synergistic lubrication mechanism of FCB composites was that FeS could prevent the crack from extending with the continuous Bi mesh and could prevent the matrix with Bi debris from peeling off, which was conducive to the formation of a lubricant‐rich tribofilm at the friction interface to improve the tribological properties of the composites.
Branding beyond the gender binary
Authors: Cooke Angelica , Russell‐Bennett Rebekah , Wang Di , Whyte Stephen 
Published: May 2022

AbstractGender is a fundamental pillar of personal identity, and as such, gendered brand personality is an equally important aspect of brand identity, as it enables consumers to express their gender identity through consumption. However, as gender attitudes and identities change to reflect the broader culture, marketers must continuously re‐evaluate how changing gender attitudes and identities will impact consumers' responses to gendered brands. This paper examines the effect of congruence between Gendered Brand Personality and consumer psychological gender on brand outcomes using two online experiments with USA and UK samples. Our findings indicate that congruence between brand gender and psychological gender increases brand equity and purchase intention in brand gender communication contexts including through logo, model, and usage setting. This congruence effect is driven by consumer self‐referencing. A follow‐up qualitative study using a focus group adds additional insights for the congruence effect in terms of potential boundary conditions and alternative underlying mechanisms beyond self‐referencing. These findings suggest that marketers should design their own brand personality to be in line with target consumers' psychological gender.
A novel variant of GLI3, p.Asp1514Thrfs*5, is identified in a Chinese family affected by polydactyly
Authors: Wang Yusi , Hao Xuguang , Jia Xueyuan , Ji Wei , Yuan Shuai , Gnamey Estelle Judith Abla , Huang Min , Xu Lidan , Zhang Xuelong , Bai Jing , Sun Wenjing , Fu Songbin , Liu Yong , Wu Jie 
Published: May 2022

AbstractBackgroundPolydactyly is a common congenital malformation characterized by the presence of supernumerary fingers or toes. In this case study, we sought to identify the causative pathogenic factor in a family from a northern region of China affected by non‐syndromic postaxial polydactyly (PAP).MethodsAfter recruiting a three‐generation family with PAP, whole‐exome sequencing was performed to identify the causative variant. In silico analysis and Sanger sequencing were used to validate the variant.ResultsWe identified a novel heterozygous frameshift variant (NM_000168.6:c.4540delG, p.Asp1514Thrfs*5) in the transcriptional activator (TA1) domain of the GLI3 gene.ConclusionThe novel frameshift variant identified in this study further confirms the relationship between non‐syndromic PAP and GLI3 and extends the previously established mutational and phenotypic spectra of GLI3.
Plate‐related complication and health‐related quality of life after mandibular reconstruction by fibula flap with reconstruction plate or miniplate versus anterolateral thigh flap with reconstruction plate
Authors: Chang Tzu‐Yen , Lai Yen‐Shuo , Lin Chung‐Ying , Wang Jung‐Der , Pan Shin‐Chen , Shieh Shyh‐Jou , Lee Jing‐Wei , Lee Yao‐Chou 
Published: May 2022

AbstractBackgroundPlate‐related complications are major long‐term complications in mandible reconstruction. There are controversies regarding the use of a reconstruction plate versus miniplates and a bone flap versus a soft tissue flap with a bridging plate. Direct comparisons of a fibula flap and an anterolateral thigh flap, the applicability between a reconstruction plate and miniplate, and the correlation between plate‐related complications and quality of life remain unclarified. Therefore, this study aimed to the explore complications of different flaps and plates and how they impact the patients' quality of life.MethodsWe retrospectively reviewed the medical records of a total of 205 patients aged >18 years who underwent segmental mandibulectomy and reconstruction using fibula flap with reconstruction plate (FR; n = 86), fibula flap with miniplate (FM; n = 61), and anterolateral thigh flap with reconstruction plate (AR; n = 58) due to cancer ablation, osteoradionecrosis, or benign tumor excision between August 2010 and December 2019. Data on characteristics, complications, and health‐related quality of life were collected and analyzed.ResultsThe plate‐related complication rate was the highest in the AR group (37.9%), then in the FR group (25.6%), and was the lowest in the FM group (13.1%; p = 0.0079). The plate exposure rate was the highest in the AR group (24.1%), then in the FR group (15.7%), and was the lowest in the FM group (4.9%; p = 0.0128). The plate fracture and dislodge rates for the AR group were both higher than those for the FR and FM groups (24.1% versus 9.3% versus 9.8%, respectively; p = 0.023). The AR group had worse complication‐free survival (hazard ratio [HR]: 3.61, 95% CI: 1.99–6.56, and p < 0.0001) than the FR and FM groups. Osteoradionecrosis (HR: 6.19, 95% CI: 2.11–18.21, and p = 0.0009) and postoperative radiotherapy (HR: 2.87, 95% CI: 1.34–6.12, and p = 0.0402) were both independent adverse factors for complication‐free survival, whereas patient treated primarily (HR: 0.35, 95% CI: 0.17–0.73, and p = 0.0048) was an independent protective factor. Plate‐related complication negatively impacted the quality of life based on pain scores (β: −0.56, SE: 0.26, and p = 0.034).ConclusionsUsing a fibular flap fixed with miniplates and avoiding the use of a reconstruction plate may yield a reduced plate exposure rate and better health‐related quality of life, particularly for patients with osteoradionecrosis or those who need postoperative radiotherapy.
A circularly polarized folded reflectarray antenna for Ka‐band satellite communications uplinks
Authors: Zhang Pan‐Pan , Zhu Xi‐Cheng , Shu Xiao‐Le , Wu Xiao‐Hu , Jiang Mei , Ge Jun‐Xiang 
Published: May 2022

AbstractA low‐profile circularly polarized folded reflectarray antenna (CPFRA) with linearly polarized (LP) feed antenna is presented in this article. Polarizing grid usually used as the subreflector of traditional FRA is replaced by a polarization‐sensitive frequency selective surface (FSS) in the CPFRA design. The polarization‐sensitive FSS is designed to convert the LP incidence into the CP wave within its passband while reflecting the orthogonal LP incident wave over its operating frequency band. A CPFRA prototype has been proposed and validated for Ka band satellite communications uplinks in this article. The maximum measured antenna gain of 26.0 dBic is achieved at 29.75 GHz with the corresponding antenna aperture efficiency of 40%. Beam scanning property has been achieved by the CPFRA with the mechanical movement of feed horn antenna. All the measured axial ratios (ARs) of the CPFRA are lower than 3 dB in the frequency range from 29 to 30.25 GHz. Meanwhile, the measured antenna gain variation with different beam scanning angles is less than 1 dB from 29.25 to 31 GHz.
X/Ku dual‐band single‐layer reflectarray antenna
Authors: Song Wenke , Cai Yang , Xue Qianzhong , Guo Naining , Liu Kegang , Li Sen , Wang Jing , Ding Haibing 
Published: May 2022

AbstractIn this article, a single‐layer dual‐band reflectarray (RA) antenna is proposed. The RA antenna operates at two separated frequency bands with separate feeds. A low‐profile dual‐band unit cell I is designed with a 2 mm thickness without an air layer, which comprises only one dielectric substrate and two layers of metal patches. To achieve 360° phase shift ranges at two bands, unit cell II is presented based on the phase delay line theory. On the basis of proposed unit cells, a single‐layer circular RA (D = 150 mm) is designed, fabricated, and measured. The measured results show a measured peak gain of 20.7 dBi at 10.5 GHz and a 1 dB bandwidth of 17% (9.8–11.5 GHz). Besides, a measured peak gain of 23.6 dBi can be achieved at 15 GHz, and the 1 dB bandwidth is 13.3% (13.8–15.8 GHz) at Ku band.
A broadband and high‐gain differentially fed suspended plate antenna integrated with solar cells
Authors: Lai Jingyu , Luo Yu , Yan Ningning , An Wenxing , Ma Kaixue 
Published: May 2022

AbstractThis paper proposes a differentially fed suspended plate antenna (SPA) integrated with solar cells. A structure of hollow cylinders is used to support the patch and enhance the gain by suppressing any unwanted high‐order mode. More importantly, the cathode of the solar cells is connected to the antenna ground to improve the compatibility of the antenna and solar cells without introducing additional filters. Differentially fed l‐shaped coaxial probes feed the SPA to enhance the bandwidth. The anode and the cathode of the two solar cells are connected and located directly above the patch. A prototype of the solar cell SPA is fabricated and measured to verify the stability of its radiation and energy‐harvesting performance. The measurement results show that the bandwidth of the proposed solar cell SPA is 3.2–5.1 GHz for wideband application, and its gain is higher than 9.51 dBi in the operating band.
The maintenance conversion scheduling problem: Models and insights
Authors: Bowers Melissa R. , Bichescu Bogdan C. , Bryan Nana , Polak George G. , Gilbert Kenneth , Keene Doug 
Published: May 2022

AbstractThe maintenance conversion scheduling problem (MCSP) is faced by organizations such as those in the airline, defense, heavy equipment, and transportation industries switching from an asset maintenance program with longer, less‐frequent service visits to one with shorter, more frequent visits. One example is the United States Air Force (USAF) High Velocity Maintenance program piloted at the Warner Robbins Air Logistics Center on the C‐130 aircraft line. The USAF MCSP is complex, as planners must schedule significantly more aircraft depot maintenance visits during the conversion period and must determine the timing and specific order in which each aircraft completes a repetitive sequence of maintenance visits. The conversion is expected to yield a stable long‐term maintenance schedule, while balancing annual depot workload and operating within reasonable flow times and work‐in‐process levels. While practically important, this problem has received little to no attention in the literature. Therefore, this research formalizes the general MCSP within an optimization framework, shows the MCSP is NP‐complete, proposes a computationally effective solution approach, and shows that a balanced long‐term schedule depends critically on the conversion period schedule. Our solutions are markedly better than USAF proposed schedules and underscore the value of leveraging synergies between asset availability and maintenance efficiency. Our approach moves the focus away from batch scheduling toward a smoother, more uniform, mixed‐model type schedule that yields more stable maintenance operations and a more consistent, predictable level of aircraft readiness. The manuscript concludes with a discussion of the main theoretical and practical implications of our work.
Event‐triggered output tracking control for switched systems: An adaptive stay interval scheme
Authors: Qi Yiwen , Yu Wenke , Huang Jie , Yu Yang 
Published: May 2022

AbstractThis article studies output tracking control for switched systems with an adaptive stay interval based event‐triggering scheme. By considering limited communication and computation resources, an event‐triggering scheme based on stay interval is adopted. To further improve the adjustment capability of network communication, an adaptive stay interval which can be changed depend on system performance is presented. A class of tracking controllers with error integral terms are applied to make switched systems have more accurate tracking performance. Then, closed‐loop switched systems that composed by system state and tracking error are modeled, and a set of sufficient conditions for ensuring systems achieve the desired output tracking performance is given. By using linear matrix inequalities, the controller gains and event‐triggering parameters are obtained. In particular, since variable stay interval, triggering instants, and switching instants are mutually inclusive, various cases are fully analyzed to guarantee the integrity of system performance discussion. Finally, simulation examples are shown to demonstrate the feasibility.
Carbon Dots from Natural Sources for Biomedical Applications
Authors: Ayiloor Rajesh Gopika , John Varsha Lisa , Pookunnath Santhosh Aiswarya , Krishnan Nair Ambika Athira , Thavarool Puthiyedath Vinod 
Published: May 2022

AbstractCarbon dots (CD), a class of 0D nanomaterials, have gained much research attention over the years due to their uniqueness in properties such as tunable photoluminescence, biocompatibility, low toxicity, water‐solubility, and chemical stability. Converting inexpensive biomass to valuable materials highlights the synthesis and applications of biomass‐derived CDs. This review summarizes the research and development related to the synthesis, properties, and applications of biomass‐derived CDs, furnishing a comprehensive list of biomass‐derived CDs with their properties and potential applications. This review's discussions and references span the properties that equip CDs for their diverse biomedical applications, such as bioimaging, sensing, drug delivery, phototherapy, and nanomedicine.
Area deprivation and respiratory morbidities in children with bronchopulmonary dysplasia
Authors: Banwell Emma , Collaco Joseph M. , Oates Gabriela R. , Rice Jessica L. , Juarez Lucia D. , Young Lisa R. , McGrath‐Morrow Sharon A. 
Published: May 2022

AbstractIntroductionInfants and children diagnosed with bronchopulmonary dysplasia (BPD) have a higher likelihood of recurrent hospitalizations and asthma‐like symptoms. Socio‐environmental factors that influence the frequency and severity of pulmonary symptoms in these children during the preschool age are poorly understood. In this study, we used the Area Deprivation Index (ADI) to evaluate the relationship between the socio‐environmental exposures in children with BPD and respiratory outcomes during the first few years of life.MethodsA registry of subjects recruited from outpatient BPD clinics at Johns Hopkins University (n = 909) and the Children's Hospital of Philadelphia (n = 125) between January 2008 and October 2021 was used. Subjects were separated into tertiles by ADI scores aggregated to ZIP codes. Caregiver questionnaires were used to assess the frequency of respiratory morbidities and acute care usage for respiratory symptoms.ResultsThe mean gestational age of subjects was 26.8 ± 2.6 weeks with a mean birthweight of 909 ± 404 g. The highest tertile (most deprived) of ADI was significantly associated with emergency department visits (aOR 1.72; p = 0.009), hospital readmissions (aOR 1.66; p = 0.030), and activity limitations (aOR 1.55; p = 0.048) compared to the lowest tertile. No association was seen with steroid, antibiotic or rescue medication use, trouble breathing, or nighttime symptoms.ConclusionIn this study, children with BPD who lived in areas of higher deprivation were more likely to be rehospitalized and have ED visits for respiratory reasons. Identifying socio‐environmental factors that contribute to adverse pulmonary outcomes in children with BPD may provide opportunities for earlier interventions to improve long‐term pulmonary outcomes.
The synergistic effects of rosehip oil and matrine against Icerya aegyptiaca (Douglas) (Hemiptera: Coccoidea) and the underlying mechanisms
Authors: Zhou Yi , Wu Jiyingzi , Lin Sukun , He Junlang , Deng Yangyang , He Jingchao , Cheng Dongmei 
Published: May 2022

AbstractBACKGROUNDIcerya aegyptiaca (Douglas) is an important agricultural pest that has a protective wax shell. Insecticides generally fail to achieve the desired control of I. aegyptiaca because of difficulties penetrating this wax shell. Plant essential oils are rich in terpenoids and have strong penetrability and expansibility, which can enable the rapid penetration and absorption of insecticides, thereby improving the control effect. Matrine is a botanical insecticide with contact and stomach toxicity, low toxicity toward non‐target organisms and is environmentally friendly. In this study, we tested the insecticidal activity of rosehip oil (Ro)/matrine combinations and revealed the synergistic mechanism of Ro and its components with matrine in terms of physiology and biochemistry.RESULTSRo/matrine combinations have strong penetrating power, enabling matrine to quickly penetrate the wax shell of I. aegyptiaca and enter the insect body. This improves the insecticidal activity and enhances inhibition of acetylcholinesterase activity. Ro and its main chemical constituents, cineole and (+)‐camphor, showed synergistic effects on matrine with synergic ratios of 4.79, 3.49 and 4.21, respectively.CONCLUSIONCombinations of Ro, cineole and (+)‐camphor with matrine have good insecticidal effects on I. aegyptiaca while remaining safe to the environment. These combinations of biological insecticides have excellent development prospects and provide a new reference for the pest management of scale insects. © 2022 Society of Chemical Industry.
Pulmonary pseudoaneurysm presented as a lung nodule after recovering from Covid‐19 pneumonia
Authors: Somboonviboon Dujrath , Wattanathum Anan 
Published: May 2022

AbstractPulmonary pseudoaneurysms (PAPs) are an uncommon complication of severe acute respiratory syndrome coronavirus 2 infection, although they are a potentially life‐threatening condition. We present this interesting condition of severe coronavirus disease 2019 (Covid‐19) pneumonia. The patient presented with abnormal lung nodule and developed massive haemoptysis after recovering from Covid‐19 pneumonia. PAP was diagnosed by computed tomography angiography. Endovascular embolization was performed and the bleeding was stopped.
Fixed‐time output feedback stabilization of a class of high‐order planar nonlinear systems
Authors: Yao Qijia 
Published: May 2022

AbstractIn this article, the fixed‐time output feedback stabilization of a class of high‐order planar nonlinear systems is addressed. A fixed‐time output feedback controller is originally designed by using the bi‐limit homogeneous method and integrating with an auxiliary filter to estimate the unmeasured state. The local fixed‐time stability of the resulting closed‐loop system is theoretically proved. Moreover, the proposed controller is structurally simple and has the strong robustness against uncertainties, which makes it affordable for practical applications. Finally, numerical simulations are presented to verify the effectiveness and advantages of the proposed controller.