bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Management of Laryngomalacia in Patients With Pierre Robin Sequence
Authors: Bakeman Anna E. , Shaffer Amber D. , Tobey Allison B. J. , Jabbour Noel , Ford Matthew D. , Goldstein Jesse A. , Simons Jeffrey P. 
Published: June 2022

Objective To characterize the prevalence and presentation of laryngomalacia and efficacy of supraglottoplasty (SGP) in a cohort of patients with Pierre Robin Sequence (PRS). Design Retrospective cohort study. Setting Tertiary-care children's hospital. Patients, Participants Consecutive patients with PRS born between January 2010 and June 2018. Main Outcome Measures Chart review included demographics, comorbid airway obstruction including laryngomalacia, timing of surgical interventions, clinical symptoms, sleep study data, and modified barium swallow study data. 126 patients with PRS were included; 54% had an associated syndrome, 64% had an overt cleft palate, and 22% had a submucous cleft palate. 64/126 were noted to have laryngomalacia (51%). Patients with concurrent PRS and laryngomalacia were significantly more likely to have submucous cleft palate ( P = .005) and present with aspiration with cough ( P = .01) compared to patients with PRS without laryngomalacia. Patients with concurrent laryngomalacia and PRS showed a significant decrease in apnea–hypopnea index (AHI) and obstructive AHI (OAHI) after mandibular distraction, with a median AHI and OAHI improvement of 22.3 ( P = .001) and 19.8 ( P = .002), respectively. Patients who underwent only SGP did not show significant improvement in these parameters ( P = .112 for AHI, P = .064 for OAHI). The prevalence of laryngomalacia in our PRS cohort was 51%. Patients with PRS and laryngomalacia are more likely to present with overt aspiration compared to patients with PRS without laryngomalacia. These data support that laryngomalacia does not appear to be a contraindication to pursuing MDO.
Frontalis suspension by a minimally invasive “harvesting-stripping technique” for congenital blepharoptosis in children under 3-years-old
Authors: Evereklioglu Cem 
Published: June 2022

Purpose To describe a minimally-invasive “harvesting-stripping technique” on a small segment of autogenous fascia lata (AFL) in small children with severe blepharoptosis under 3-years-old. Methods A single-surgeon, uncontrolled surgical trial was designed for 25 eyelids of 18 small children (5 girls, 13 boys) with severe blepharoptosis. Single- and short-skin incisions (2-cm) were made on the thigh and a final 3X0.6-cm or 3.5X1-cm AFL segment was excised according to the ptosis laterality. The surface area of the harvested AFL was calculated and dissected for a final 9-cmX2-mm-long fascial strip for each eye. Functional and aesthetic outcomes of the upper eyelids were evaluated and the feasibility, effectivity and advantages of this novel approach in younger patients were assessed. Results The mean age was 28.3 months (17–35) with a mean follow-up of 34.3 months (6–96). All eyelids achieved good or excellent functional and aesthetic results (except one), with no peri- or post-operative severe complications such as haemorrhage, wound infection, hypertrophied thigh scar, muscle prolapses, eyelid contour abnormalities, ptosis recurrence or overcorrection. Conclusions “Harvesting-stripping technique” with the AFL may be an alternative approach to correct severe upper blepharoptosis in small children under 3-years-old, which offers various benefits over conventional methods with non-autogenous materials.
Telemedicine evaluation of new head and neck patients at a tertiary academic clinic during the coronavirus disease 2019 pandemic
Authors: Xie Katherine Z , Antezana Luis A , Bowen Andrew J , Yin Linda X , Yeakel Sarah , Nassiri Ashley , Moore Eric J 
Published: June 2022

Introduction Coronavirus disease 2019 accelerated the use of virtual visits within health care. We examined the utility of telemedicine for conducting visits in a tertiary head and neck practice. Methods A retrospective study was conducted on patients presenting via video to a tertiary-level head and neck clinic between January 2020 and December 2020. Patient demographics were collected in addition to visit indication, diagnostic imaging/tests at the time of visit, and post-visit plan. Visits were deemed successful if evaluation by video was sufficient in determining a clinical plan and did not require deferment of recommendations for subsequent in-person consult visits and/or work-up (labs, imaging). Logistic regression was performed to identify variables that served as significant predictors of successful video visits. Results A total of 124 video visits were reviewed. Video visits were successful for the initial evaluation 88.7% of the time ( n = 110). Computerized tomographic scans were the most available diagnostic test, available for 54% of patients ( n = 67), followed by biopsy report 30.6% ( n = 38). Visit indication had a statistically significant effect on whether a treatment plan could be made ( p = 0.024). For new patients with parotid masses ( n = 42), definitive treatment plans could be made 97.6% of the time ( n = 41). Patients presenting with an indication of thyroid mass (odds ratio: 0.19 (confidence interval: 0.00072–0.50), p = 0.018) and other neck mass (odds ratio: 0.035 (confidence interval: 0.0014, 0.90), p = 0.043) were at significantly lesser odds than parotid patients to have a successful video visit. Discussion In this study, virtual visits were successful for a high percentage of head and neck visits, particularly among patients seeking evaluation for parotid-related concerns.
Telemonitoring of motor skills using the Alberta Infant Motor Scale for at-risk infants in the first year of life
Authors: Lima Camila Resende Gâmbaro , Verdério Bruna Nayara , de Abreu Raissa Wanderley Ferraz , Brugnaro Beatriz Helena , dos Santos Adriana Neves , dos Santos Mariana Martins , Rocha Nelci Adriana Cicuto Ferreira 
Published: June 2022

Introduction Remote assessment creates opportunities for monitoring child development at home. Determining the possible barriers to and facilitators of the quality of telemonitoring motor skills allows for safe and effective practices. We aimed to: (1) determine the quality, barriers and facilitators of Alberta Infant Motor Scale (AIMS) home videos made by mothers; (2) verify interrater reliability; (3) determine the association between contextual factors and the quality of assessments. Methods Thirty infants at biological risk aged between three and ten months, of both sexes, and their mothers were included. Assessments were based on asynchronous home videos, where motor skills were evaluated by mothers at home according to AIMS guidelines. The following were analyzed: video quality; stimulus quality; camera position; and physical environment. The video characteristics were analyzed descriptively. The intraclass correlation coefficient was used to calculate interrater reliability and the regression model to determine the influence of contextual factors on the outcome variables. Significance was set at 5%. Results Remote assessment of AIMS exhibited high image and stimulus quality, and a suitable physical environment. Interrater reliability was high for all domains: prone ( r = 0.976); supine ( r = 0.965); sitting ( r = 0.987); standing ( r = 0.945) and total score ( r = 0.980). The contextual factors had no relation with assessment quality. Discussion Assessments conducted remotely by the mothers showed high video quality and interrater reliability, and represent a promising assessment tool for telemedicine in at-risk infants in the first year of life.
L1 and L2 vocabulary and word combinations of preschool children from migrant families in Italy
Authors: Bello Arianna , Ferraresi Paola , Stefanini Silvia , Perucchini Paola 
Published: June 2022

Purpose: This study aimed to examine the L1 and L2 linguistic profiles of preschool bilingual children of migrants, to compare the evaluations of their parents and teachers, and to identify the children with low L2 lexical skills. Method: The expressive vocabulary and word combinations of these bilingual children were assessed with the MacArthur Bates Communicative Development Inventories (MB-CDI) short-form questionnaire, by both parents, to evaluate L1 and L2-Italian, and teachers, to evaluate L2. Interviews were carried out with the parents to collect the demographic and linguistic variables. Data and analysis: The sample comprised 60 preschool bilingual children of migrants (chronological age: 37–62 months) with 15 first language (L1) minority backgrounds, and exposed to L2-Italian. A total of 60 families and 44 nursery school teachers also participated. Conclusion: Almost two-thirds (61.4%) of these preschool bilingual children of migrants showed greater expressive vocabulary in L2 than L1. The children’s word combinations were advanced in L2 in 84.8%, and in L1 in 27.1%. Parents attributed higher language skills in L2-Italian to their children than teachers, although assessments of parents and teachers were correlated. Almost a quarter of the children (24.6%) showed low lexical skills in L2, which is explained by shorter exposure time to L2 at school. Originality: The characteristics of the L1 and L2 linguistic profiles of preschool bilingual children have been little studied to date, although these children are increasingly present in school contexts. There is the need to identify children who are slow in acquisition of L2, along with the contextual-linguistic factors that explain this slowed language acquisition. Implications: The availability of a relevant and rapid tool (MB-CDI questionnaire) to estimate knowledge in L1 and L2 that is suitable for migrant parents and teachers provides important information for assessment of the L2 skills of such bilingual children of migrants.
Finding lost words: The ‘savings effect’ in the Irish language context
Authors: Barry Shane 
Published: June 2022

Aims: By applying the savings paradigm to determine the presence of residual Irish language knowledge, this study seeks to investigate the relearning advantage for the acquisition of words likely to have been acquired during the second language acquisition of Irish compared with newly acquired Irish words. Furthermore, self-efficacy will be assessed as a robust self-assessed predictor of performance. Methodology: Using a corpus of Irish language, low- and high-frequency nouns were used to create a list of ‘old’ and ‘new’ words. Thirty-six participants were tested over 2 months, across three phases. Each participant was provided with a relearning session before being tested on their individualised list of 40 words. Participants were asked to rate their self-efficacy confidence levels before each testing session. Data and analysis: An online survey platform was used at each phase to test residual knowledge and to gather self-efficacy and attitudinal data. Correlation analyses and independent t-tests were carried out to measure the effect sizes over the 2-month time period of testing. Findings: The data provide evidence that Irish nouns likely to have been previously encountered, but since forgotten, are recalled more efficiently than newly encountered Irish nouns. Furthermore, evidence of cognateness as a retrieval strategy reveals an active Irish language residual knowledge base. Originality: This paper is the first effort in applying the savings paradigm methodology, as demonstrated in de Bot et al., to the Irish language context, and is the first attempt at measuring perceived pre-test Irish language abilities using self-efficacy. Implications: With Irish language as a compulsory school subject in Ireland, and so few daily users of the language, the identification of residual Irish knowledge in a population that has not used the language in decades may encourage reactivation of a language presumed to be forgotten.
Effects of Fu’s subcutaneous needling on mitochondrial structure and function in rats with sciatica
Authors: Li Yaping , Gao Xianghui , Huang Hailiang , Zhou Xiyan , Zang Yunhua , Chou Li-Wei 
Published: June 2022

To observe the effects of Fu’s subcutaneous needling (FSN) and acupuncture treatment on the mitochondrial structure and function of the skeletal muscle tissue of rats with sciatica. Forty Sprague–Dawley rats were divided into control, model, acupuncture, and FSN groups (10 each) according to a random number table. The control group was left untreated. Rats in the FSN group were treated with FSN once every 2 days for three times, respectively (days 1, 3, 5, and 7), to cooperate with reperfusion approach. The acupuncture group was treated at the same timeline as that of the FSN group. Changes in the mechanical pain threshold, mitochondrial ultrastructure, mitochondrial citrate synthase (CS) activities, mitochondrial respiratory chain complex II, and mitochondrial COX- I protein expression in the skeletal muscle of rats treated with different treatments were compared with those of the model group. The pain thresholds of the rats were remarkably higher after FSN treatment and acupuncture, and the pain threshold of the FSN group was higher than that of the acupuncture group. Compared with the control group, the mitochondria of the model group had a damaged ultrastructure, were arranged in a disorganized manner, accumulated under the basement membrane, and appeared vacuolated with autophagosomes. The state of mitochondria in the FSN group was close to that in the control group and was remarkably better than that in the acupuncture group. The activities of mitochondrial CS and respiratory chain complex II in the skeletal muscle of the treated rats decreased compared with the control group ( p < 0.05), and their levels were better in the FSN group than in the acupuncture group ( p < 0.05). FSN treatment for 1 week considerably improved the pain thresholds and improved the skeletal muscle mitochondrial ultrastructure and mitochondrial function in rats with sciatica.
The patient acceptability of a remotely delivered pain management programme for people with persistent musculoskeletal pain: A qualitative evaluation
Authors: Booth Gregory , Zala Sonia , Mitchell Chloe , Zarnegar Roxaneh , Lucas Andrew , Gilbert Anthony W 
Published: June 2022

Introduction Remotely delivered pain management programmes have been offered in place of in-person programmes by many chronic pain services since the onset of the COVID-19 pandemic. There is a lack of evidence regarding the acceptability of these programmes. In this evaluation, we have explored patients’ acceptability of a remotely delivered pain management programme for patients with persistent musculoskeletal pain. Methods Qualitative data were collected using focus groups with participants who had previously attended the remote pain management programme. Data were analysed using abductive analysis. Results Three focus groups were conducted with a total of 13 participants. The programmme was either entirely acceptable, had some acceptable components or was not acceptable to patients. Factors leading to the programme being acceptable include learning to manage pain from home, receiving high quality care from home, enhancing the potential of rehabilitation using technology, enabling attendance on a pain management programme from home, overcoming social distancing requirements of COVID-19 using technology, and virtual peer support. Factors leading to the programme not being acceptable include having an inappropriate home environment for virtual therapy, communication challenges with virtual therapy, technological issues and concerns regarding the quality of care. Conclusions There is a spectrum of acceptability with respect to the remote programme. The factors that influence this are dynamic, individual and situational. Hybrid programmes have the potential to enhance access to pain management programmes and improve patient experience and programme outcomes in the future.
A case of a delayed granulomatous reaction on the face following microneedling: A case report
Authors: Heck Emma , Traboulsi Danya 
Published: June 2022

Background: Microneedling is a common non-invasive procedure used for a variety of dermatologic conditions. It is associated with a low rate of adverse events which are typically temporary. Hypersensitivity reactions, including granuloma formation, are a rare adverse event, with only 10 cases previously reported. Case Summary: We report a case of a 49-year-old female who presented with asymptomatic edematous erythematous annular plaques on her left cheek following a microneedling procedure in which a Vitamin C cosmeceutical was applied to the skin beforehand. Skin biopsy confirmed non-necrotizing granulomatous dermatitis with negative tissue cultures. Systemic workup for sarcoidosis was negative. Conclusion: Delayed facial granulomatous reaction is an uncommon adverse event following microneedling. Increased risk may be related to peri-procedure use of cosmeceuticals such as Vitamin C. Given the popularity of microneedling, and that it is an unregulated procedure, it is important for dermatologists to be aware of this possible sequela in order to counsel patients appropriately and understand management options.
Pancreatic leiomyosarcoma in a domestic shorthair cat
Authors: Bobis Villagrá Diego , Almeida Mariana , Cox Alistair , Henderson Elisabeth 
Published: June 2022

Case summary A 7-year-old female neutered domestic shorthair cat was presented with weight loss, abdominal distension, lethargy, pyrexia and hyporexia. Haematology and biochemistry were unremarkable. Abdominal ultrasound revealed a cystic mass within the left cranial abdominal quadrant, adjacent to the pancreas, stomach and spleen. CT revealed a 10.5 cm, rounded, well-encapsulated, hypodense mass arising from the left pancreatic lobe. The remaining organs of the abdominal and thoracic cavity were unremarkable. A partial left lobe pancreatectomy and splenic lymph node removal were performed. Histopathology of the pancreatic mass reported a proliferating population of neoplastic spindle cells most consistent with a preliminary diagnosis of soft tissue sarcoma. Immunohistochemistry characteristics, together with the morphological findings, were consistent with a diagnosis of leiomyosarcoma. The patient recovered without any concerns after receiving routine postoperative care. Clinical examination and abdominal ultrasound 5 months postoperatively revealed no abnormalities. Relevance and novel information To our knowledge, this is the first report of pancreatic leiomyosarcoma in a cat. Pancreatic leiomyosarcoma should be considered as one of the possible differential diagnoses for cats presenting with a pancreatic mass.
Reported Side Effects of COVID-19 Vaccination among Adults in Saudi Arabia: A Cross-Sectional Study
Authors: Alhowaymel Fahad , Abdelmalik Mohammed A. , Mohammed Almoez M. , Mohamaed Mohamaed O. , Alenezi Atallah 
Published: June 2022

Background The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2, is a major international crisis. Although vaccination is the only hope to end this pandemic, adverse effects attributable to vaccines are still being reported. Active surveillance is critical for generating near-real-time, high-quality evidence for potential safety hazards, allowing us to respond quickly to vaccination Purpose To investigate the prevalence of side effects following COVID-19 vaccination with Oxford–AstraZeneca among adults in northwestern Riyadh Province, Saudi Arabia. Methods This is a cross-sectional and community-based study performed among individuals who had received any type of COVID-19 vaccination. A convenience sampling method was used to collect data using an online survey. Results A total of 222 individuals responded to the survey, and the majority frequently reported both localized and systemic side effects after vaccination. The most reported side effects include pain at the site of injection, myalgia, headache, and fever. Some demographic factors were significantly associated with the reported post-vaccination side effects. Conclusion The most prevalent side effects experienced by individuals after receiving the COVID-19 vaccine were determined in this study. Prior to the administration of a vaccination, counseling programs should be established to help people understand and deal with the possible side effects, with a special focus on demographic differences.
Safety and efficacy of endoscopic sleeve gastroplasty for obesity management in new bariatric endoscopy programs: a multicenter international study
Authors: Sarkar Avik , Tawadros Augustine , Andalib Iman , Shahid Haroon M. , Tyberg Amy , Alkhiari Resheed , Gaidhane Monica , Kedia Prashant , John Elizabeth S. , Bushe Bryce , Martinez Guadalupe Ma , Zamarripa Felipe , Carames Mine C. , Carames Juan C. , Casarodriguez Fernando , Bove Vincenzo , Costamagna Guido , Boskoski Ivo , Kahaleh Michel 
Published: June 2022

Background: Endoscopic sleeve gastroplasty (ESG) is an incisionless procedure that reduces the size of the gastric cavity. In prior studies, it has been proven to be a safe and effective treatment for obesity. In this study, we performed a collaborative study to evaluate the effectiveness of ESG among new endobariatric programs. Methods: This was an international, multicenter study reviewing the outcomes of ESG in centers starting ESG programs. Total body weight loss, change of body mass index (BMI), excess body weight loss (EBWL), technical success, duration of hospitalization, and immediate and delayed adverse events and complications at 24 h, 1 week, and 1, 3, and 6 months post-procedure were evaluated. Results: A total of 91 patients (35 males) from six centers were included. The patients’ mean BMI before the procedure was 38.7 kg/m2. BMI reduction at 3 months was 7.3 ( p < 0.000), at 6 months 9.3 ( p < 0.000), and at 12 months 8.6 ( p < 0.000) from baseline. EBWL was 17.3% at 1 month ( p < 0.000), 29.2% at 3 months ( p < 0.000), and 35.6% at 6 months ( p < 0.000). The mean procedure duration was 85.1 min. The mean length of hospital stay post-procedure was 27 h. Conclusion: ESG provides EBWL percentage sustained up to 12 months. These results are equivalent among the new ESG centers compared to previous studies by expert centers. Lay title Endoscopic sleeve gastroplasty in new bariatric endoscopy programs: Plain Language Summary This article is the result of a collaborative international study on new endoscopic programs offering endoscopic sleeve gastroplasty. The minimally invasiveness and increasing accessibility of this technique makes it very attractive for patients with obesity while being poor candidate for surgery or refusing surgery. This study will also provide valuable information regarding this rising technique of endobariatric treatment.