bluuebunny/crossref_metadata_2025_split huggingface dataset:
De Wegiz: wettelijk verplichte elektronische gegevensuitwisseling in de zorg
Authors: Nouwt J. 
Published: June 2022

De Wegiz: wettelijk verplichte elektronische gegevensuitwisseling in de zorg
Dit artikel gaat over het wetsvoorstel elektronische gegevensuitwisseling in de zorg (Wegiz). Het bespreekt de inhoud van het wetsvoorstel en van de zorgdomeinen waar de verplichte elektronische gegevensuitwisseling als eerste in werking zullen treden. Ook de bestaande juridische kaders komen aan bod. Tot slot volgt een blik op toekomstige Europese regelgeving.
Pelatihan Pembuatan Preparat Segar dan Awetan Jamur Serta Cara Mengidentifikasi Jamur Mikroskopik Bagi Guru Biologi Sekolah Menengah Atas
Authors: Swandi Monica Kharisma , Salmi Salmi 
Published: June 2022

Kegiatan pelatihan pembuatan preparat segar dan awetan jamur serta cara mengidentifikasi jamur mikroskopik bagi Guru Biologi Sekolah Menengah Atas dilaksanakan dalam rangka pengabdian kepada masyarakat. Kegiatan ini bertujuan untuk meningkatkan kompetensi guru biologi melalui kuliah singkat, pelatihan persiapan preparat segar dan awetan serta identifikasi jamur mikroskopik. Pelatihan dilakukan secara daring menggunakan aplikasi zoom meeting dan dilaksanakan dalam 4 sesi : kuliah singkat, kerja kelompok untuk identifikasi jamur, diskusi, dan evaluasi. Tingkat pengetahuan peserta dievaluasi dua kali, sebelum kuliah singkat dan setelah sesi diskusi dengan menggunakan google-form. Analisis secara statistik menggunakan paired sample t-test menunjukkan bahwa adanya peningkatan pengetahuan dan kemahiran peserta dalam mengidentifikasi jamur mikrokopik secara signifikan (p<0.05). Pada akhir pelatihan, peserta juga mendapatkan video pembelajaran, buku saku dan preparat jamur awetan. Kami berharap apa yang diperoleh guru biologi selama mengikuti workshop dapat diaplikasikan pada proses pembelajaran di sekolah masing-masing, sehingga siswa dapat memahami materi jamur dengan lebih mudah.
Edukasi Pengobatan Swamedikasi Batuk Flu Pada Anak
Authors: Risma Sakti Pambudi  
Published: June 2022

Swamedikasi merupakan upaya yang sering dilakukan oleh seseorang dalam mengobati gejala sakit atau penyakit yang sedang dideritanya sebelum konsultasi kepada dokter. Swamedikasi akan berefek buruk kika terjadi kesalahan dalam mengenali gejala , pemilihan obat, dosis dan keterlambatan dalam mencari informasi. Sehingga hal ini dapat menjadi salah satu faktor terjadinya medication error. Batuk dan Flu seringkali terjadi pada kalangan anak-anak. Orang tua perlu mendapatkan pemahaman dan pengetahuan terkait swamedikasi batuk dan flu yang dapat dilakukan secara farmakologi dan tradisional. Upaya yang dapat dilakukan adalah dengan memberikan edukasi swamedikasi pada masyarakat. Kegiatan edukasi ini bertujuan untuk meningkatkan edukasi masyarakat sekitar tentang swamedikasi batuk dan pilek pada anak. Metode yang digunakan dalam pengabdian ini adalah melalui edukasi menggunakan media brosur. Edukasi dilakukan untuk memberikan pengetahuan kepada peserta dan menghindari rasa panik jika anak mengalami batuk dan flu. Respon peserta terhadap pemberian edukasi baik dan hasil menunjukkan bahwa peserta memahami terkait swamedikasi batuk dan flu pada anak (95%).
Inventarisasi Tumbuhan Obat Tradisional Di Wilayah Bendungan Mila Kabupaten Dompu
Authors: Wahyuningsih Daniah , Juhaini Juhaini , Novita Heny , Nurafiatullah Nurafiatullah , Rosninda Rosninda , Awalyah Yonanda , Suryani Suryani , Oktaviana Mia , Ade Ningsih Tri , Azmin Nikman , Nasir Muh 
Published: June 2022

Jumlah tumbuhan obat di Indonesia bervariasi, hingga saat ini jumlahnya belum banyak diketahui seacara pasti, sehingga diperlukan pendokumentasian secara menyeluruh untuk pemanfaatan tumbuhan sebagai bahan baku pengobatan. Penelitian bertujuan untuk mengetahui jenis-jenis tumbuhan obat dan bagian yang di manfaatkan serta khashiat tumbuhan. Metode penelitian yang digunakan yaitu kombinasi teknik survei lapangan (observasi), terhadap masyarakat di wilayah Bendungan Mila Kabupaten Dompu. Populasi dalam penelitian ini adalah seluruh masyarakat wilayah bendungan mila kabupaten dompu. Sampel dalam penelitian ini adalah masyarakat yang memiliki pengetahuan tentang pengobatan tradisional dengan pemanfaatan tumbuhan obat. Analisis data menggunakan analisis deskriptif kualitatif, hasil penelitian menunjukan bahwa tumbuhan obat tradisional yang dimanfaatkan sebagai obat sebanyak 19 jenis tumbuhan bekhasiat obat yang digunakan dalam pengobatan tradisional
Studi Keanekaragaman Tumbuhan Obat Tradisional Di Wilayah Bendungan Mila Kabupaten Dompu
Authors: Mulisa Mulisa , Hayatun Atun , Rizki Reni , Putri Nanda , Mirnawati Eti , Putri Zahra Nurul , Natalia Nafa , Apriati Mira , Mahdalena Serlin , Haryati Haryati , Azmin Nikman , Nurlailah Nurlailah 
Published: June 2022

Penelitian ini bertujuan untuk mempelajari tumbuhan obat di Kawasan Bendungan Mila Kabupaten Dompu. Metode yang digunakan adalah survey lapangan dan wawancara. Penelitian ini berguna untuk mengetahuai jenis tumbuhan apa saja yang dimanfaatkan sebaagai obat-obatan tradisoanal. Hasil penelitian ini menunjukkan bahwa ada 15 jenis tumbuhan obat tradisonal yang digunakan dan dimanfaatkan oleh masyarakat. Bagian tumbuhan obat tradisoanal biasa digunakan masyarakat sebagai obat yaitu daun, batang, kulit, buah, biji, umbi, kayu, dan akar. Adapun cara pengolahan tumbuhan obat tradisional yaitu dengan cara direbus, ditempel, digosok, ditumbuk, dan di konsumsi secara langsung.
Study of Serum Level of Interleukin 33 in Systemic Lupus Erythematosus Patients
Authors: Saqr Rana Gamal , Elsharaby Radwa Mahmoud , Shahba Abeer Abdelmenem , Hazzaa Sahar Mohey Eldin 
Published: June 2022

Background: Systemic lupus erythematosus (SLE) is a chronic disease in which the immune system of the body attacks body tissues in multiple body systems, so it is called autoimmune disease. Arthritis, skin rash, photosensitivity, and nephritis are the most common clinical presentation in SLE. Interleukin 33 (IL-33) is one of the interleukins family, and it is established that IL-33 is central in inborn and acquired immunity. Historically, the IL-33 receptor was discovered first on the surface of T helper 2 cells and not T helper T1 cells.
Aim: Measuring Interleukin-33 level in serum of SLE patients and its relation to clinical presentation, activity, and severity of the disease.
Subjects and Methods: This study was conducted at Clinical Pathology and Internal Medicine Departments-Tanta University Hospital from March 2019 to December 2019 on 80 subjects
Results: The affected females were at the childbearing period, and the incidence among gender is higher for females than that for males, which reflects the hormonal role in SLE development. Serum creatinine, blood urea nitrogen, ESR levels were increased significantly in SLE patients than in the control group. There was a significant increase in serum IL-33 levels in SLE patients than control group indicating that IL-33 has a role in the pathogenesis of SLE. There was a significant difference in Hb, platelet count, ANA, and anti-ds-DNA between SLE patients and the control group. There was a significant positive correlation between IL-33 and serum creatinine, ESR, CRP, and SLEDAI. The most common feature was arthritis (88.3%) of patients, followed by skin rash (60.0%) of patients.
Conclusion: IL-33 levels in patients with SLE were significantly higher than that in the control group, and its level was significantly related to disease activity. This indicated that IL-33 has a role in the pathogenesis of SLE. So, IL-33 can be used as a diagnostic and a prognostic marker.
Assessment of burden and segregation profiles of CNVs in patients with epilepsy
Authors: Moreau Claudia , Tremblay Frédérique , Wolking Stefan , Girard Alexandre , Laprise Catherine , Hamdan Fadi F. , Michaud Jacques L. , Minassian Berge A. , Cossette Patrick , Girard Simon L. 
Published: June 2022

AbstractObjectiveMicrodeletions are associated with different forms of epilepsy but show incomplete penetrance, which is not well understood. We aimed to assess whether unmasked variants or double CNVs could explain incomplete penetrance.MethodsWe analyzed copy number variants (CNVs) in 603 patients with four different subgroups of epilepsy and 945 controls. CNVs were called from genotypes and validated on whole‐genome (WGS) or whole‐exome sequences (WES). CNV burden difference between patients and controls was obtained by fitting a logistic regression. CNV burden was assessed for small and large (>1 Mb) deletions and duplications and for deletions overlapping different gene sets.ResultsLarge deletions were enriched in genetic generalized epilepsies (GGE) compared to controls. We also found enrichment of deletions in epilepsy genes and hotspots for GGE. We did not find truncating or functional variants that could have been unmasked by the deletions. We observed a double CNV hit in two patients. One patient also carried a de novo deletion in the 22q11.2 hotspot.InterpretationWe could corroborate previous findings of an enrichment of large microdeletions and deletions in epilepsy genes in GGE. We could also replicate that microdeletions show incomplete penetrance. However, we could not validate the hypothesis of unmasked variants nor the hypothesis of double CNVs to explain the incomplete penetrance. We found a de novo CNV on 22q11.2 that could be of interest. We also observed GGE families carrying a deletion on 15q13.3 hotspot that could be investigated in the Quebec founder population.
Inkjet‐Printed Xerogel Scaffolds Enabled Room‐Temperature Fabrication of High‐Quality Metal Electrodes for Flexible Electronics
Authors: Wang Shuaichen , Gao Yuan , Huang Qiyao , Guo Xuyun , Yang Anneng , Zhang Yaokang , Zhuang Qiuna , Chen Dongdong , Chen Lina , Ju Xin , Hu Hong , Zhang Shengdong , Zhu Ye , Yan Feng , Zheng Zijian 
Published: June 2022

AbstractInkjet‐printed metal electrodes with desirable morphologies and electrical properties are indispensable cornerstones for printable and flexible electronics. However, methods to fabricate metal electrodes nowadays mostly request the sintering of printed metal particles, which not only will easily damage heat‐sensitive plastic substrates, but also is difficult to achieve a smooth, neat, and highly adhesive electrode structure. Herein, a room‐temperature, solution‐processable copper (Cu) electrode is demonstrated to overcome the above issues. The key is to inkjet print a stable xerogel scaffold with high porosity, good uniformity, and smoothness for growing high‐quality Cu via electroless deposition. Xerogel‐based Cu electrodes exhibit a bi‐layer architecture, consisting of an upper thin‐film Cu (with an electrical conductivity of ≈1.2 × 107 S m−1) and a bottom Cu‐polymer interpenetrated network. The electrodes show an excellent uniformity, surface smoothness, high interfacial energy to the plastic substrates (690–970 mJ m−2), and good flexibility. Taking these merits, the electrodes can be patterned onto various plastic substrates and fabricate all‐solution‐processed electronic devices such as organic thin‐film transistors and organic electrochemical transistors with stable electrical performance.
27.6% Perovskite/c‐Si Tandem Solar Cells Using Industrial Fabricated TOPCon Device
Authors: Wu Yiliang , Zheng Peiting , Peng Jun , Xu Menglei , Chen Yihua , Surve Sachin , Lu Teng , Bui Anh Dinh , Li Nengxu , Liang Wensheng , Duan Leiping , Li Bairu , Shen Heping , Duong The , Yang Jie , Zhang Xinyu , Liu Yun , Jin Hao , Chen Qi , White Thomas , Catchpole Kylie , Zhou Huanping , Weber Klaus 
Published: June 2022

AbstractThe tandem cell structure is the most promising solution for the next generation photovoltaic technology to overcome the single‐junction Shockley–Queisser limit. The fabrication of a perovskite/c‐Si monolithic tandem device has not yet been demonstrated on a c‐Si bottom cell produced from an industrial production line. Here, a c‐Si cell with a tunneling oxide passivating contact (TOPCon) structure produced on a production line as the bottom cell of a tandem device, and a top cell featuring solution‐processed perovskite films to form the tandem device are used. The c‐Si cell features a rough damage etched, but untextured front surface from the wafering processes. To combat the challenge of rough surfaces, several strategies to avoid shunt paths across carrier transport layers, absorber layers, and their interfaces are implemented. Moreover, the origin of reflection loss on this planar structure is investigated and the reflection loss is managed to below 4 mA cm−2. In addition, the source of the voltage loss from the TOPCon bottom cell is identified and the device structure is redesigned to be suitable for tandem applications while still using mass production feasible fabrication methods. Overall, 27.6% efficiency is achieved for a monolithic perovskite/c‐Si tandem device, with significant potential for future improvements.
Ink Engineering in Blade‐Coating Large‐Area Perovskite Solar Cells
Authors: Yang Jinxin , Lim Eng Liang , Tan Li , Wei Zhanhua 
Published: June 2022

AbstractTo date, organic–inorganic hybrid perovskite solar cells (PSCs) have reached a certified efficiency of 25.7%, showing great potential in upscale industrial commercialization. However, a huge obstacle facing the industrialization of PSCs is the decreased efficiency and long‐term stability when upscaling the device area. To overcome these issues, blade‐coating methods have been developed to fabricate large‐area PSCs due to their capability to deposit uniform large‐area perovskite films. Ink engineering plays an important role in the blade‐coating, especially for crystallinity and defect control. In this review, the blade‐coating method to fabricate large‐area perovskite films is first introduced. Then, the perovskite ink engineering for blade‐coating PSCs is systematically summarized. Specifically, the effects of perovskite composition management and solvent engineering on perovskite film quality are discussed, and recent efforts in additive strategy to passivate perovskite defects are also summarized. Subsequently, recent advances in functional layer ink engineering and fully blade‐coated PSCs are summarized. Moreover, the applications of blade‐coating method in hole transporting material‐free carbon‐based PSCs are discussed. Finally, some suggestions and an outlook on this field are provided to help facilitate highly efficient and stable blade‐coated PSCs.
Chemically Tuning Attractive and Repulsive Interactions between Solubilizing Oil Droplets
Authors: Wentworth Ciera M. , Castonguay Alexander C. , Moerman Pepijn G. , Meredith Caleb H. , Balaj Rebecca V. , Cheon Seong Ik , Zarzar Lauren D. 
Published: June 2022

AbstractMicellar solubilization is a transport process occurring in surfactant‐stabilized emulsions that can lead to Marangoni flow and droplet motility. Active droplets exhibit self‐propulsion and pairwise repulsion due to solubilization processes and/or solubilization products raising the droplet's interfacial tension. Here, we report emulsions with the opposite behavior, wherein solubilization decreases the interfacial tension and causes droplets to attract. We characterize the influence of oil chemical structure, nonionic surfactant structure, and surfactant concentration on the interfacial tensions and Marangoni flows of solubilizing oil‐in‐water drops. Three regimes corresponding to droplet “attraction”, “repulsion” or “inactivity” are identified. We believe these studies contribute to a fundamental understanding of solubilization processes in emulsions and provide guidance as to how chemical parameters can influence the dynamics and chemotactic interactions between active droplets.
Miscibility and rigid amorphous phase in blends of polypropylene with poly(propylene‐co‐ethylene)
Authors: Darweesh Mohamed H. , El‐Taweel Safaa H. , Stoll Bernhard 
Published: June 2022

AbstractThermal and mechanical properties of binary blends of polypropylene (PP) with a statistical copolymer (85 wt% propylene and 15 wt% ethylene, abbreviated here as VM) have been investigated. Both components were found to be miscible in the melt in the whole range of compositions. No separate domains of VM have been detected by polarizing optical microscopy, and the size of spherulites is going down with increasing VM content. The crystallization temperature of PP as detected by DSC, is going down to 83°C, for PP/VM blends 10:90. This is another evidence for miscibility in the melt. Viscoelastic properties of the melt were measured. Regarding the solid state, the melting enthalpy is exactly proportional to the PP content in the blend. The DSC step height at the glass transition is exactly proportional to the VM content. These results are suggesting a three‐phase model (crystalline, rigid amorphous, and mobile amorphous phase), where the VM component is mainly located in the mobile amorphous regions, while the amorphous part of PP is in the rigid amorphous regions. Stress–strain curves show a systematic increase of elongation at break with increasing VM%, to be extended from 7.8% to more than 550%.
A new subseasonal atmospheric teleconnection bridging tropical deep convection over the western North Pacific and Antarctic weather
Authors: Sun Yuexiang , Tan Benkui 
Published: June 2022

AbstractPrevious studies indicate that convective heating variability of the western North Pacific summer monsoon (WNPSM) influences strongly weather and climate over East Asia. Based on daily reanalysis data and interpolated outgoing longwave radiation (OLR) data, this study demonstrates that the WNPSM convection can also cause severe weather events remotely over the Antarctic through the exciting of the Australia‐South Pacific‐Atlantic wave train (ASPA pattern). Surface air temperature (SAT) rises over the Ross Sea‐Mawson‐Dumont d'Urville Seas sector and over the Weddell Sea, while the SAT drops over the Amundsen–Bellingshausen Seas. Concurrently, sea ice concentration (SIC) is reduced over the Ross Sea and enhanced over the Amundsen–Bellingshausen Seas. The result suggests that the newly found ASPA pattern may serve as an important bridge linking the WNPSM convection and the weather over the Antarctic region.The dynamics of ASPA's formation and propagation are also investigated comprehensively. Day‐to‐day energy budget analysis suggests that after its initiation by WNPSM convection, the ASPA pattern is driven by the baroclinic energy conversion from the climatological flow and nonlinear term. The barotropic energy conversion from the climatological flow contributes to positive KE tendency before day +1 and negative KE tendency after day +1. It is therefore extremely important to improve the representations of the climatological‐mean sea ice and jet stream, wave‐mean flow interaction and wave‐wave interaction in the mid‐ and high‐latitudes of the Southern Hemisphere, as well as the convection over the WNPSM region of the Northern Hemisphere in numerical model for a better weather prediction for the Antarctic.
Nonlinear age effects in tactile processing from early childhood to adulthood
Authors: Kaur Sakshi , Espenhahn Svenja , Bell Tiffany , Godfrey Kate J. , Nwaroh Chidera , Giuffre Adrianna , Cole Lauran , Beltrano Winnica , Yan Tingting , Stokoe Mehak , Haynes Logan , Hou Tasha Yuntao , Tommerdahl Mark , Bray Signe , Harris Ashley D. 
Published: June 2022

AbstractBackgroundTactile processing plays a pivotal role in the early stages of human development; however, little is known about tactile function in young children. An understanding of how tactile processing changes with age from early childhood to adulthood is fundamental in understanding altered tactile experiences in neurodevelopmental disorders, such as autism spectrum disorder.MethodsIn this cross‐sectional study, 142 children and adults aged 3–23 years completed a vibrotactile testing battery consisting of 5 tasks, which rely on different cortical and cognitive mechanisms. The battery was designed to be suitable for testing in young children to investigate how tactile processing changes from early childhood to adulthood.ResultsOur results suggest a pattern of rapid, age‐related changes in tactile processing toward lower discrimination thresholds (lower discrimination thresholds = greater sensitivity) across early childhood, though we acknowledge limitations with cross‐sectional data. Differences in the rate of change across tasks were observed, with tactile performance reaching adult‐like levels at a younger age on some tasks compared to others.ConclusionsWhile it is known that early childhood is a period of profound development including tactile processing, our data provides evidence for subtle differences in the developmental rate of the various underlying cortical, physical, and cognitive processes. Further, we are the first to show the feasibility of vibrotactile testing in early childhood (<6 years). The results of this work provide estimates of age‐related differences in performance, which could have important implications as a reference for investigating altered tactile processing in developmental disorders.
Development and validation of postoperative and preoperative platelets ratio (PPR) to predict the prognosis of patients undergoing surgery for colorectal cancer: A dual‐center retrospective cohort study
Authors: Yang Wei , Zheng Xiaoying , Wu Minghui , Zhang Fengming , Xu Shuizhi , Wang Xiuchao , Song Menghui , You Chang , Zhang Ting , Jiang Minghua , Ding Chunming 
Published: June 2022

AbstractBackgroundPlatelets occupy a prominent place in tumor proliferation and metastasis, and platelet count is relevant to the prognosis of tumor patients. But preoperative platelet counts cannot be standardized and individualized due to the variability among individuals, instruments, and regions, and the connection between postoperative platelet count and prognosis remains unknown. A standardized indicator of platelet count was designed to forecast the prognosis of colorectal cancer (CRC).MethodsFive hundred and eighty six patients who suffered radical resection of CRC between 2013 and 2019 were collected. A development‐validation cohort of standardized and individualized platelet counts for prognostic assessment of CRC was designed. We first determined the ability of PPR and other peripheral blood count‐related indicators to predict the mortality of patients with CRC and validated them in a separate cohort. Kaplan–Meier analysis was executed to evaluate the survival and univariate and multivariate analyses were executed to explore the relevance. Time‐dependent ROC was measured to estimate the predictive usefulness. Decision curve analysis was used to verify the clinical net benefit.ResultsImportant baseline variables showed a similar distribution in two independent queues. In the development cohort, postoperative platelet count and postoperative/preoperative platelets ratio (PPR) were independent predictors of prognosis in CRC patients. PPR showed the largest area under the curve (AUC) in evaluating 1‐year and 5‐year OS (AUC: 0.702 and 0.620) compared to others. In the validation cohort, platelet/lymphocyte ratio and PPR were validated to be independently concerned about OS of CRC patients and PPR showed the largest AUC in evaluating 1‐year and 3‐year OS (AUC: 0.663 and 0.673). PPR and joint index of platelet count and PPR showed better predictive value and clinical net benefit.ConclusionsPPR has been identified and validated to be independently concerned about OS of patients with CRC and was a reliable and economic indicator to evaluate the prognosis.