bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases
Authors: Wong Lai , Sami Alina , Chelico Linda 
Published: November 2022

Abstract
The human APOBEC family of eleven cytosine deaminases use RNA and single-stranded DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has roles in lipid metabolism by altering mRNA coding, adaptive immunity by causing evolution of antibody genes, and innate immunity through inactivation of viral genomes. These benefits come at a cost where some family members, primarily from the APOBEC3 subfamily (APOBEC3A-H, excluding E), can cause off-target deaminations of cytosine to form uracil on transiently single-stranded genomic DNA, which induces mutations that are associated with cancer evolution. Since uracil is only promutagenic, the mutations observed in cancer genomes originate only when uracil is not removed by uracil DNA glycosylase (UNG) or when the UNG-induced abasic site is erroneously repaired. However, when ssDNA is present, replication protein A (RPA) binds and protects the DNA from nucleases or recruits DNA repair proteins, such as UNG. Thus, APOBEC enzymes must compete with RPA to access their substrate. Certain APOBEC enzymes can displace RPA, bind and scan ssDNA efficiently to search for cytosines, and can become highly overexpressed in tumor cells. Depending on the DNA replication conditions and DNA structure, RPA can either be in excess or deficient. Here we discuss the interplay between these factors and how despite RPA, multiple cancer genomes have a mutation bias at cytosines indicative of APOBEC activity.
Corporate Taxation and International Financial Integration: U.S. evidence from a consolidated perspective
Authors: Bénétrix Agustín , Sanchez Pacheco André 
Published: November 2022

Abstract
We document a robust relation between corporate tax differentials and US international financial integration (IFI). While this is the case for traditional IFI based on cross-border positions, the positive link also emerges for its larger consolidated-by-nationality version. The gap between these IFI measures, the key outcome variable in our analysis, exhibits a strong positive correlation with tax differentials too. This is in part due to consolidated assets of multinational enterprises being more strongly correlated with tax differentials than their cross-border counterpart. We interpret this as indirect evidence of US multinationals taking advantage of tax differentials in ways that go beyond what is captured by traditional Balance of Payments procedures.
JEL: F36, F21, F23, H87.
Mantle-Derived Cargo vs Liquid Line of Descent: Reconstructing the P–T–fO2–X Path of the Udachnaya–East Kimberlite Melts during Ascent in the Siberian Sub-Cratonic Lithosphere
Authors: Casetta Federico , Asenbaum Rene , Ashchepkov Igor , Abart Rainer , Ntaflos Theodoros 
Published: November 2022

Abstract
Disentangling the physico-chemical evolution of the melts that give rise to kimberlites during their genesis, ascent through the sub-cratonic lithosphere and emplacement in the crust is challenging. This is because the extensive entrainment and assimilation of, and reaction with, mantle-derived material makes kimberlites mixtures of xenocrystic, magmatic components and alteration minerals, rarely preserving evidence of their original melt composition. Here, a detailed textural and compositional study of coherent and volcaniclastic kimberlite units from the Udachnaya–East pipe (Siberian craton) was performed to reconstruct the pressure–temperature–oxygen fugacity-compositional (P–T–fO2–X) path of kimberlite melts during their ascent through the sub-cratonic lithosphere. Routine and high-precision electron microprobe analyses of olivine, phlogopite and Fe–Ti oxides enabled to discriminate the mantle-derived cargo from the magmatic components, and thus make inferences on the liquid line of descent (LLD) of proto-kimberlite to kimberlite melts. Most of the olivine cores in Udachnaya–East kimberlite are xenocrystic and record conditions of last equilibration in the Siberian sub-cratonic lithospheric mantle at T–P ranging from 812–1227°C at 3.1–5.4 GPa, to 871–1170°C at 4.6–7.0 GPa, depending on the chosen model geotherm (35 mW/m2 vs 40 mW/m2). Based on their Ni, Cr, Mn, Al and P vs Mg/Fe systematics, olivine core populations were associated to the sheared, granular garnet-bearing or spinel-bearing cratonic peridotites. The occurrence of olivine Internal Zones (I) having the same composition as Fe-rich cores, as well as rare mantle-derived xenocrystic cores of phlogopite, bear witness of mantle metasomatism preceding kimberlite ascent. The assimilation of mantle material by initially H2O- and P-rich proto-kimberlitic melts is recorded by the cotectic formation of magmatic olivine Internal Zones (II) and phlogopite Internal Zones around resorbed xenocrystic cores. The LLD then evolved by inducing cotectic precipitation of olivine, phlogopite rims and Cr-spinel at P of 1.5–3.0 GPa, T of 1120–1250°C and fO2 from −2.8 to −1.6 ΔFMQ. Ilmenite–magnetite pairs in the groundmass record the later conditions of crystallization that occurred at P of ~1.0 GPa, T from 1133°C down to 1000°C and fO2 of +0.3 to +0.9 ΔFMQ. These results confirm the progressive oxidation of the melt that finally led to the formation of calcite, apatite and Mg-rich olivine and phlogopite rinds. The F-enrichment of phlogopite rinds reflects a late decrease of the H2O/CO2 activity of the melt that evolved toward alkali-carbonated composition. Our results showed that the crystal cargo of kimberlites can be used to track all processes acting in between the melt-rock reactions in the mantle and the emplacement in the crust.
Genetic variability, biomass parameters, elemental composition and energy content of the non-indigenous hydromedusa Craspedacusta sowerbii in North America
Authors: Lüskow Florian , Boersma Maarten , López-González Pablo J , Pakhomov Evgeny A 
Published: November 2022

Abstract
The freshwater hydrozoan Craspedacusta sowerbii was introduced to habitats around the world and they spread into the surrounding water bodies thereafter. Despite an increase in reported observations, little is known about its genetics, physiology and ecology. The present study examined the organic content, elemental composition and energy content of jellyfish collected in Canada and the USA and compared these metrics with their marine counterparts and other co-occurring zooplankton. Specimens from the sampled lakes were sexed and molecularly characterized. Molecular, stoichiometric and energetic information is critical in determining distribution pathways and trophic connections. Molecular analyses showed two closely related sequences in North America, one shared by the Canadian and Japanese specimens, while another one is widely present across the Americas. Organic and all elemental contents were higher compared to marine jellyfish species. Estimated energy content of C. sowerbii was 20–27 kJ g DW−1, which is 2-fold higher than for marine hydrozoans and compared well with cladocerans, copepods and rotifers. Estimated C/P values indicated that cladocerans and copepods are suitable prey for C. sowerbii and that jellyfish may compete with juvenile fish to fulfill similar nutrient demands. Freshwater jellyfish were stoichiometrically and energetically different from marine hydrozoans, indicating higher importance in freshwater food webs than previously thought.
Phytochrome B mediates dim-light-reduced insect resistance by promoting the ethylene pathway in rice
Authors: Huang Jie , Qiu Ze-Yu , He Jun , Xu Hao-Sen , Wang Kan , Du Hua-Ying , Gao Dong , Zhao Wei-Ning , Sun Quan-Guang , Wang Yong-Sheng , Wen Pei-Zheng , Li Qi , Dong Xiao-Ou , Xie Xian-Zhi , Jiang Ling , Wang Hai-Yang , Liu Yu-Qiang , Wan Jian-Min 
Published: November 2022

Abstract
Increasing planting density is one of the most effective ways to improve crop yield. However, one major factor that limits crop planting density is the weakened immunity of plants to pathogens and insects caused by dim light (DL) under shade conditions. The molecular mechanism underlying how DL compromises plant immunity remains unclear. Here, we report that DL reduces rice (Oryza sativa) resistance against brown planthopper (BPH; Nilaparvata lugens) by elevating ethylene (ET) biosynthesis and signaling in a Phytochrome B (OsPHYB)-dependent manner. The DL-reduced BPH resistance is relieved in osphyB mutants, but aggravated in OsPHYB overexpressing plants. Further, we found that DL reduces the nuclear accumulation of OsphyB, thus alleviating Phytochrome Interacting Factor Like14 (OsPIL14) degradation, consequently leading to the up-regulation of 1-Aminocyclopropane-1-Carboxylate Oxidase1 (OsACO1) and an increase in ET levels. In addition, we found that nuclear OsphyB stabilizes Ethylene Insensitive Like2 (OsEIL2) by competitively interacting with EIN3 Binding F-Box Protein (OsEBF1) to enhance ET signaling in rice, which contrasts with previous findings that phyB blocks ET signaling by facilitating Ethylene Insensitive3 (EIN3) degradation in other plant species. Thus, enhanced ET biosynthesis and signaling reduces BPH resistance under DL conditions. Our findings provide insights into the molecular mechanism of the light-regulated ET pathway and host-insect interactions and potential strategies for sustainable insect management.
Structure-based engineering of minimal proline dehydrogenase domains for inhibitor discovery
Authors: Bogner Alexandra N , Ji Juan , Tanner John J 
Published: November 2022

Abstract
Proline dehydrogenase (PRODH) catalyzes the FAD-dependent oxidation of l-proline to Δ1-pyrroline-5-carboxylate and is a target for inhibitor discovery because of its importance in cancer cell metabolism. Because human PRODH is challenging to purify, the PRODH domains of the bacterial bifunctional enzyme proline utilization A (PutA) have been used for inhibitor development. These systems have limitations due to large polypeptide chain length, conformational flexibility and the presence of domains unrelated to PRODH activity. Herein, we report the engineering of minimal PRODH domains for inhibitor discovery. The best designs contain one-third of the 1233-residue PutA from Sinorhizobium meliloti and include a linker that replaces the PutA α-domain. The minimal PRODHs exhibit near wild-type enzymatic activity and are susceptible to known inhibitors and inactivators. Crystal structures of minimal PRODHs inhibited by S-(−)-tetrahydro-2-furoic acid and 2-(furan-2-yl)acetic acid were determined at 1.23 and 1.72 Å resolution. Minimal PRODHs should be useful in chemical probe discovery.
On weak compactness in projective tensor products
Authors: Rodríguez Josè 
Published: November 2022

Abstract
We study the property of being strongly weakly compactly generated (and some relatives) in projective tensor products of Banach spaces. Our main result is as follows. Let $1 \lt p,q \lt \infty$ be such that $1/p+1/q\geq 1$. Let X (resp., Y) be a Banach space with a countable unconditional finite-dimensional Schauder decomposition having a disjoint lower p-estimate (resp., q-estimate). If X and Y are strongly weakly compactly generated, then so is their projective tensor product $X {\widehat{\otimes}_\pi} Y$.
Therapeutic consequences in patients with both inflammatory rheumatic diseases and multiple sclerosis
Authors: Letarouilly Jean-Guillaume , Vermersch Patrick , Flipo René-Marc 
Published: November 2022

AbstractDealing with patients with both multiple sclerosis (MS) and inflammatory rheumatic disorders (IRDs) is not uncommon for a rheumatologist, as there is a statistical association between SpA and MS. As several CNS demyelinating events have been reported in patients treated with TNF inhibitor (TNFi), the pre-existing demyelinating disease was considered a contraindication for TNFi. However, this contraindication is mainly based on a randomized controlled trial in MS and not on large epidemiological studies. According to the last epidemiological studies, TNFi might not be an inducer of MS. Moreover, there are no clear recommendations on the use of the other DMARDs in patients suffering from an IRD and MS. In this review, we summarize the link between MS and IRDs and the impact of DMARDs on MS, especially TNFi. We also look at the impact of disease-modifying drugs for adults with MS and IRDs.
Cross-Modality Evidence for Reduced Choice History Biases in Psychosis-Prone Individuals
Authors: Eckert Anna-Lena , Gounitski Yael , Guggenmos Matthias , Sterzer Philipp 
Published: November 2022

AbstractObjectivesPredictive processing posits that perception emerges from inferential processes within a hierarchical cortical system. Alterations of these processes may result in psychotic experiences, such as hallucinations and delusions. Central to the predictive processing account of psychosis is the notion of aberrant weights attributed to prior information and sensory input. Based on the notion that previous perceptual choices represent a relevant source of prior information, we here asked whether the propensity towards psychotic experiences may be related to altered choice history biases in perceptual decision-making.MethodsWe investigated the relationship between choice history biases in perceptual decision-making and psychosis proneness in the general population. Choice history biases and their adaptation to experimentally induced changes in stimulus serial dependencies were investigated in decision-making tasks with auditory (experiment 1) and visual (experiment 2) stimuli. We further explored a potential compensatory mechanism for reduced choice history biases by reliance on predictive cross-modal cues.ResultsIn line with our preregistered hypothesis, psychosis proneness was associated with decreased choice history biases in both experiments. This association is generalized across conditions with and without stimulus serial dependencies. We did not find consistent evidence for a compensatory reliance on cue information in psychosis-prone individuals across experiments.ConclusionsOur results show reduced choice history biases in psychosis proneness. A compensatory mechanism between implicit choice history effects and explicit cue information is not supported unequivocally by our data.
Comprehensive analysis of multivariable models for predicting severe dengue prognosis: systematic review and meta-analysis
Authors: Lee Hyelan , Hyun Seungjae , Park Sangshin 
Published: November 2022

ABSTRACTDengue fever has often been confused with other febrile diseases, with deterioration occurring in the later state. Many predictive models for disease progression have been developed, but there is no definite statistical model for clinical use yet. We retrieved relevant articles through Global Health, EMBASE, MEDLINE and CINAHL Plus. The Prediction Model Risk of Bias Assessment Tool was adopted to assess potential bias and applicability. Statistical analysis was performed using Meta-DiSc software (version 1.4). Of 3184 research studies, 22 were included for the systematic review, of which 17 were selected for further meta-analysis. The pooled data of predictive accuracy was as follows: the sensitivity was 0.88 (95% CI 0.86 to 0.89), the specificity was 0.60 (95% CI 0.59 to 0.60), the positive likelihood ratio was 2.83 (95% CI 2.38 to 3.37), the negative likelihood ratio was 0.20 (95% CI 0.14 to 0.0.29) and the diagnostic OR was 16.31 (95% CI 10.25 to 25.94). The area under the summary receiver operating characteristic curve value was 0.86 (SE=0.02) with 0.79 (SE=0.02) of the Cochran Q test value. The overall predictive power of models in this study was relatively high. With careful adaption and standardization, the implementation of predictive models for severe dengue could be practical in actual clinical settings.
Ejection Fraction Improvement Does Not Reflect Changes in Quality of Life Following Cardiac Resynchronization Therapy
Authors: Rizzi Scott A. , Torre Michael , Bunch T. Jared , Fang James , Hess Rachel , Rodriguez-Correa Carlos , Spertus John A. , Stehlik Josef , Zhang Mingyuan , Zhang Yue , Steinberg Benjamin A. 
Published: November 2022

Objective:
To determine if health-related quality of life (HRQoL) improvement after cardiac resynchronization therapy (CRT) correlates with improved left-ventricular ejection fraction (EF).

Background:
CRT was reported to improve EF and HRQoL in clinical trials of heart failure with reduced EF (HFrEF). It is unknown if improvements in HRQoL reflect EF response to CRT.

Methods:
We included HFrEF patients who underwent CRT and had both pre- and post-CRT HRQoL assessment. EF response was categorized as absent (0% change or decrease), modest (0%–19% increase), or significant (>20% increase). We examined the associations between EF response and generic (PROMIS) and HF-specific (KCCQ-12) HRQoL.

Results:
The group included 115 patients with mean age of 65 years and baseline EF of 31%; 39% were female (n = 45). Nineteen percent (n = 22) had significant, 57% (n = 66) modest, and 23% (n = 27) absent EF responses. AF burden across significant (8.9%), modest (4.8%), and absent EF responders (1.4%) was similar (P = 0.20). Significant improvements in KCCQ-12 (43.4–57.5, P = 0.003), current health visual analog scale (49.1–55.9, P = 0.042), PROMIS fatigue (58.9–55.1, P = 0.026), and PROMIS satisfaction (42.7–46.4, P = 0.020) resulted following CRT across all groups. There was no association between significant EF improvement and HRQoL by KCCQ-12 (nonresponse, 44.4%; modest response, 33.3%; and significant response, 22.2%) at 1 year (P = 0.52 across all groups).

Conclusion:
CRT was associated with a modest to significant EF response in a majority of patients. However, EF response did not significantly correlate with generic or HF-specific HRQoL measures. Further investigations are warranted into determinants of improved HRQoL following CRT.
New perspectives on the evolution of women's cooperation
Authors: Fox Stephanie A. , Scelza Brooke , Silk Joan , Kramer Karen L. 
Published: November 2022

A holistic, evolutionary framework about human cooperation must incorporate information about women's cooperative behaviour. Yet, most empirical research on human cooperation has centered on men's behaviour or been derived from experimental studies conducted in western, industrialized populations. These bodies of data are unlikely to accurately represent human behavioural diversity. To address this gap and provide a more balanced view of human cooperation, this issue presents substantial new data and multi-disciplinary perspectives to document the complexity of women's cooperative behaviour. Research in this issue 1) challenges narratives about universal gender differences in cooperation, 2) reconsiders patrilocality and access to kin as constraints on women's cooperation, 3) reviews evidence for a connection between social support and women's health and 4) examines the phylogenetic roots of female cooperation. Here, we discuss the steps taken in this issue toward a more complete and evidence-based understanding of the role that cooperation plays in women's and girls' lives and in building human sociality.This article is part of the theme issue ‘Cooperation among women: evolutionary and cross-cultural perspectives’.
Gender differences in cooperation across 20 societies: a meta-analysis
Authors: Spadaro Giuliana , Jin Shuxian , Balliet Daniel 
Published: November 2022

Past research hypothesized that men and women differ in their tendency to cooperate with strangers in situations that involve a conflict of interests. However, recent empirical research has provided converging evidence that men and women cooperate to a similar extent, and that differences in cooperation can emerge in response to specific situational and societal contexts. Here we analyse six decades of empirical research on human cooperation using social dilemmas (1961–2017,k= 126) conducted across 20 industrialized societies, testing pre-registered hypotheses derived from evolutionary theory and social role theory. Overall, our findings revealed little-to-no evidence for an association between gender and cooperation using different meta-analytic approaches. We did not find within-study differences in cooperation between men and women (d= 0.011, 95% CI [−0.038, 0.060]). However, cooperation was slightly higher across studies with predominantly female samples (k= 972). In addition, contrary to our predictions, gender differences in cooperation did not emerge in response to the degree of conflicting interests in the situation, and societal levels of gender equality and economic development. We discuss the implications of these findings for our understanding of gender differences in cooperation.This article is part of the theme issue ‘Cooperation among women: evolutionary and cross-cultural perspectives’.
Thriving together: the benefits of women's social ties for physical, psychological and relationship health
Authors: Bedrov Alisa , Gable Shelly L. 
Published: November 2022

The relationship between social support and well-being is well established in social psychology, with evidence suggesting that these benefits are especially prominent among women. When faced with an environmental stressor, women are more likely to adopt a tend-and-befriend strategy rather than fight-or-flight. Furthermore, female friendships tend to be higher in self-disclosure and more frequently relied on for social support, which is associated with physical and psychological benefits. Women are also more effective at providing social support, further augmenting those benefits. We begin with an overview of the characteristics of women's social ties and how they can be especially useful in times of stress. We then transition to the benefits of female social networks even in the absence of negative events and incorporate research from health and social psychology to consider the positive implications of having strong social bonds and the negative implications of lacking such bonds. Additionally, we consider cross-cultural differences in tendencies to seek out social support and its subsequent benefits, as well as the need for more research with culturally diverse samples. It remains unclear the extent to which patterns of social support benefits for women vary cross-culturally.This article is part of the theme issue ‘Cooperation among women: evolutionary and cross-cultural perspectives’.