bluuebunny/crossref_metadata_2025_split huggingface dataset:
The outcomes of ultrafiltration in on-pump versus off-pump coronary artery bypass grafting in patients with renal impairment
Authors: Phothikun Amarit , Nawarawong Weerachai , Tantraworasin Apichat , Tepsuwan Thitipong 
Published: August 2022

AbstractObjectiveIn chronic kidney disease (CKD), using cardiopulmonary bypass (CPB) may contribute to renal dysfunction. Off-pump coronary artery bypass grafting (OPCAB) is one technique that preserved renal function, but the procedure may not be possible in certain situations. The ultrafiltration (UF) can remove excess fluid and inflammatory mediators that result from exposure to the CPB. Coronary artery bypass grafting (CABG) with UF could be an alternative way to preserve renal function.MethodA retrospective study of CKD patients who underwent CABG. The renal outcomes were compared between the patients who underwent CABG with UF and OPCAB. A repeated measure adjusted by propensity score was used for comparing the renal outcome. Univariable and multivariable logistic regression was used to identify the risk factors for acute renal failure (AKI) and adverse outcomes.ResultsFrom January 2009 and June 2020, there were 220 CKD patients, 109 (49.55%) patients underwent CABG with UF, and 111 (50.45%) patients underwent OPCAB. There were statistically significant differences in the change of the average level of creatinine between CABG with UF (increased + 0.09 mg/dl) and OPCAB (decreased − 0.05 mg/dl) (p = 0.043). Also, patients who underwent CABG with UF had a significantly increased risk for AKI (OR 5.38, 95%CI 1.09, 26.5).ConclusionThe UF adjunct technique in CABG with CPB tends to provide a lower protective effect for renal function and had a significantly higher incidence of post-cardiac surgery AKI when compared to OPCAB. If technically feasible, OPCAB would be a preferable choice for CKD patients.Study registration number: SUR-2562-06607/Research ID: 6607.
Classification of avulsion fractures of the fifth metatarsal base using three‐dimensional CT mapping and anatomical assessment: a retrospective case series study
Authors: He Wenbao , Zhou Haichao , Zhang Yingqi , Yu Tao , Xia Jiang , Zhao Youguang , Yang Yunfeng , Li Bing 
Published: August 2022

AbstractBackgroundTo clarify the injury mechanism of the avulsion fracture of the fifth metatarsal combining 3‐dimensional (3D) fracture mapping with anatomical measurements.MethodsTwo hundred twenty‐two patients with the avulsion fractures of the fifth metatarsal base, who were admitted to our hospital from August 2015 to August 2020. The computed tomography (CT) scans were used to generate the 3‐D images of all mapped fracture lines for the avulsion fractures of the fifth metatarsal base were compiled in an overall 3D image. The fifth metatarsal base of 8 unpaired lower limbs of adult Asian frozen cadaveric specimens were also dissected to observe and measure the specific locations of the attachment points of the peroneus brevis, lateral band of the plantar fascia, and peroneus tertius to the fifth metatarsal base.ResultsBased on the type of fracture line produced and the specific locations of the attachment points of the tendons or fascia, the avulsion fractures of the fifth metatarsal base can be classified into three types: type I predominantly involves the action of the lateral band of the plantar fascia; type II predominantly involves the action of the peroneus brevis; type IIIA involves the joint action of the peroneus brevis and lateral band of the plantar fascia with one fracture line, and type IIIB involves the joint action of the peroneus brevis and lateral band of the plantar fascia with two fracture lines.ConclusionThe lateral band of the plantar fascia and peroneus brevis play a major role, either separately or together, in avulsion fractures of the fifth metatarsal base. With this knowledge, we propose a novel classification based on the injury mechanism, which can serve as a reference for clinical treatment and diagnosis.Level of evidenceLevel III, retrospective case series.
Effect of vegetable residues incorporation on soil fertility, rhizosphere microbial community structure, and plant growth of continuously cropped cucumber in a solar greenhouse
Authors: Chen Xiaolu , Zhang Dalong , Li Xiaoya , Li Xiaotian , Lou Jie , Wei Min 
Published: August 2022

Abstract
Purpose
Incorporating crop residues into the soil is considered a sustainable and valuable method to alleviate soil deterioration caused by continuous monoculture in greenhouse production. However, the effect of vegetable residues retention on soil amendments is poorly understood. In the present study, we investigated the impacts of sweet pepper, tomato, and cucumber plant residues on soil microbial communities and plant growth of continuously cropped cucumber in a solar greenhouse.

Methods
The 16S rRNA and ITS1 rRNA genes were amplified, and high-throughput sequencing was performed to explore the impacts of vegetable residues incorporation on soil microbial communities. Additionally, soil chemical properties, cucumber root vigor, and fruit yield were measured to assess the impacts of vegetable residues incorporation on continuously cropped soil and cucumber growth.

Results
The results showed that incorporating vegetable residues could improve soil buffering capacity, increase the content of soil organic matter and available nutrients, and increased the diversity of soil microorganisms and improved community structure; vegetable residues increased the abundance of beneficial bacteria such as Actinobacteria, Firmicutes, Proteobacteria, and Chloroflexi, while reducing the quantity of soil-borne pathogens such as Bacillariophyta and Acidobacteria. Similar results were observed for the fungal communities: the relative abundance of Ascomycota was decreased to varying degrees, while the relative abundance of Rozellomycota and Basidiomycota was raised. The results demonstrated that vegetable residues incorporation significantly increased cucumber root vigor and enhanced fruit yield. The effects of different types of residues on improving soil properties were ordered sweet pepper plant residues > cucumber plant residues > tomato plant residues, and 20% of sweet pepper plant residues incorporation had the most significant effect on crop yield.

Conclusion
In summary, returning vegetable residues alleviated soil continuous cropping obstacles by improving the soil fertility and the diversity and community structure of soil microorganisms, and consequently promoting the growth and yield of greenhouse-grown cucumbers. The findings demonstrated that returning vegetable residues was an effective and sustainable measure for soil amendment during continuous cropping in greenhouse production.
Combination high-dose interleukin-2 and nivolumab for programmed cell death-1 refractory metastatic melanoma: a case series
Authors: Nikanjam Mina , Mullen Jaren , Yacoub Carol , Daniels Gregory A. 
Published: August 2022

Abstract
Background
Therapeutic options are needed for metastatic melanoma refractory to therapies directed against programmed cell death-1. High-dose interleukin-2 has the potential to overcome programmed cell death-1 resistance.

Case presentation
We report three consecutive Caucasian patients, two female (60 and 55 years old) and one male (56 years old), refractory to anti-programmed cell death-1 therapy who were treated with concurrent nivolumab and standard-dosing bolus high-dose interleukin-2. We did not see any unexpected toxicities with overlapping treatments as compared with either high-dose interleukin-2 or nivolumab alone.

Conclusions
The tolerance and disease control observed among the three patients in this limited series support formal exploration of this combination.
Boundary value problems for second-order causal differential equations
Authors: Wang Wenli , Wang Peiguang 
Published: August 2022

AbstractThis paper focuses on second-order differential equations involving causal operators with nonlinear two-point boundary conditions. By applying the monotone iterative technique in the presence of upper and lower solutions, with a new comparison theorem, we obtain the existence of extremal solutions. This is an extension of classical theory of second-order differential equations. Finally, we present two examples to show the usefulness of our results.
Factors affecting medication adherence among older adults using tele-pharmacy services: a scoping review
Authors: Emadi Fatemeh , Ghanbarzadegan Arash , Ghahramani Sulmaz , Bastani Peivand , Baysari Melissa T 
Published: August 2022

AbstractBackgroundMedication adherence among older adults (aged 60 and above), particularly those with chronic conditions who take several medications, is critical, and tele-pharmacy services are a way to improve medication adherence. This study sought to determine the factors influencing medication adherence (MA) in older adults using tele-pharmacy services.MethodThe Joana Briggs Institute scoping review methodology was implemented. Searches were conducted in databases PubMed, Scopus, ProQuest, Web of Science, and Embase from 2000 to the present day, to identify both qualitative and quantitative studies focusing on the use of tele-pharmacy by older people. Factors impacting MA were extracted and analyzed into themes using a qualitative approach. A concept map was also designed summarising these factors.ResultsOf 7495 articles obtained in the initial search, 52 articles met the inclusion criteria. The analysis resulted in 5 themes and 21 sub-themes representing factors that impacted MA with tele-pharmacy. These themes are divided broadly into technology and user related factors. Technology factors included design of the tele-pharmacy intervention, commercial aspects, and adherence measurement method. User factors included user-health constraints, behaviors and perceptions.ConclusionIndustry, policymakers, and stakeholders should consider using tele-pharmacy services for improving medication adherence among older adults; however, ensuring interventions facilitate communication between patients and health care teams, and are accompanied by user training and support, is essential for technology uptake and effectiveness.
Exosome-mediated effects and applications in inflammatory diseases of the digestive system
Authors: Wu Xianli , Xu Xiaolin , Xiang Yiwei , Fan Dongdong , An Qiming , Yue Gengyu , Jin Zhe , Ding Jianhong , Hu Yanxia , Du Qian , Xu Jingyu , Xie Rui 
Published: August 2022

AbstractExosomes are membranous vesicles containing RNA and proteins that are specifically secreted in vivo. Exosomes have many functions, such as material transport and signal transduction between cells. Many studies have proven that exosomes can not only be used as biomarkers for disease diagnosis but also as carriers to transmit information between cells. Exosomes participate in a variety of physiological and pathological processes, including the immune response, antigen presentation, cell migration, cell differentiation, and tumour development. Differences in exosome functions depend on cell type. In recent years, exosome origin, cargo composition, and precise regulatory mechanisms have been the focus of research. Although exosomes have been extensively reported in digestive tumours, few articles have reviewed their roles in inflammatory diseases of the digestive system, especially inflammatory-related diseases (such as reflux oesophagitis, gastritis, inflammatory bowel disease, hepatitis, and pancreatitis). This paper briefly summarizes the roles of exosomes in inflammatory diseases of the digestive system to provide a basis for research on the mechanism of inflammatory diseases of the digestive system targeted by exosomes.
Research on electroacupuncture parameters for knee osteoarthritis based on data mining
Authors: Cai Fei-hong , Li Fan-lian , Zhang Yu-chen , Li Pei-qi , Xiao Bin 
Published: August 2022

Abstract
Background
Knee osteoarthritis, a common degenerative joint disease, has been widely treated by electroacupuncture in recent years. However, there are too many parameters of the treatment currently, resulting in various applications in clinical practice. This study aims to summarize the optimal stimulation parameters of electroacupuncture for knee osteoarthritis in clinical studies by applying data mining techniques.

Methods
Four databases including Pubmed, Cochrane Library, Embase, and Web of Science were searched for clinical studies on electroacupuncture treating knee osteoarthritis from 2012 to 2021. A database was established by Microsoft Excel 2020 and analyzed by R Version 4.1.1.

Results
Forty-six articles were included according to the established criteria. The most used electroacupuncture stimulation parameters were 0.30 mm × 40 mm needle, continuous wave, low frequency of current (mainly 2 Hz), stimulation duration for 30 min per treatment, and frequency of treatment for once a day. Eighteen acupoints were mentioned and the most used ones include Dubi (ST35), Liangqiu (ST34), Neixiyan (EX-LE4), Xuehai (SP10), Yanglingquan (GB34), and Yinlingquan (SP9), and those most generally used acupoints are closely arranged on the Stomach Channel of Foot Yangming. Cluster analysis showed two groups, one for obligatory acupoints and one for adjunctive ones. The association analysis showed the most supported acupoint pair was Liangqiu (ST34) and Xuehai (SP10).

Conclusions
Continuous wave, low frequency of current (2 Hz), 30-min stimulation, and local acupoint selection are frequently used for electroacupuncture treating knee osteoarthritis. Due to the limitations of this study, further research and more standardized, multi-centered, and large-sample clinical trials should be conducted to provide more convincing evidence.
Maternal obesity alters methylation level of cytosine in CpG island for epigenetic inheritance in fetal umbilical cord blood
Authors: Ma Zhuoyao , Wang Yingjin , Quan Yanmei , Wang Zhijie , Liu Yue , Ding Zhide 
Published: August 2022

Abstract
Background
Over the past few decades, global maternal obesity prevalence has rapidly increased. This condition may induce long-lasting pathophysiological effects on either fetal or infant health that could be attributable to unknown unique changes in the umbilical blood composition.

Methods
A total of 34 overweight/obese and 32 normal-weight pregnant women were recruited. Fifteen umbilical blood samples including 8 overweight/obese subjects and 7 normal weight women were sequenced using Targeted Bisulfite Sequencing technology to detect the average methylation level of cytosine and identify the differentially methylated region (DMR). GO and KEGG analyses were then employed to perform pathway enrichment analysis of DMR-related genes and promoters. Moreover, the mRNA levels of methylation-related genes histone deacetylases (HDACs) and DNA methyltransferases (DNMTs) were characterized in the samples obtained from these two groups.

Results
Average methylated cytosine levels in both the CpG islands (CGI) and promoter significantly decreased in overweight/obese groups. A total of 1669 DMRs exhibited differences in their DNA methylation status between the overweight/obese and control groups. GO and KEGG analyses revealed that DMR-related genes and promoters were enriched in the metabolism, cancer and cardiomyopathy signaling pathways. Furthermore, the HDACs and DNMTs mRNA levels trended to decline in overweight/obese groups.

Conclusions
Decreased methylated cytosine levels in overweight/obese women induce the gene expression activity at a higher level than in the control group. DMRs between these two groups in the fetal blood may contribute to the changes in gene transcription that underlie the increased risk of metabolic disorders, cancers and cardiomyopathy in their offspring.
Geophysical model generation with generative adversarial networks
Authors: Puzyrev Vladimir , Salles Tristan , Surma Greg , Elders Chris 
Published: August 2022

AbstractWith the rapid development of deep learning technologies, data-driven methods have become one of the main research focuses in geophysical inversion. Applications of various neural network architectures to the inversion of seismic, electromagnetic, gravity and other types of data confirm the potential of these methods in real-time parameter estimation without dependence on the starting subsurface model. At the same time, deep learning methods require large training datasets which are often difficult to acquire. In this paper, we present a generator of 2D subsurface models based on deep generative adversarial networks. Several networks are trained separately on realistic density and stratigraphy models to reach a sufficient degree of accuracy in generation of new highly detailed and varied models in real-time. This allows for creation of large synthetic training datasets in a cost-effective manner, thus facilitating the development of better deep learning algorithms for real-time inversion and interpretation.
Adaptive coordination control strategy of renewable energy sources, hydrogen production unit, and fuel cell for frequency regulation of a hybrid distributed power system
Authors: Salama Hossam S. , Magdy Gaber , Bakeer Abualkasim , Vokony Istvan 
Published: August 2022

AbstractOwing to the significant number of hybrid generation systems (HGSs) containing various energy sources, coordination between these sources plays a vital role in preserving frequency stability. In this paper, an adaptive coordination control strategy for renewable energy sources (RESs), an aqua electrolyzer (AE) for hydrogen production, and a fuel cell (FC)-based energy storage system (ESS) is proposed to enhance the frequency stability of an HGS. In the proposed system, the excess energy from RESs is used to power electrolysis via an AE for hydrogen energy storage in FCs. The proposed method is based on a proportional-integral (PI) controller, which is optimally designed using a grey wolf optimization (GWO) algorithm to estimate the surplus energy from RESs (i.e., a proportion of total power generation of RESs: Kn). The studied HGS contains various types of generation systems including a diesel generator, wind turbines, photovoltaic (PV) systems, AE with FCs, and ESSs (e.g., battery and flywheel). The proposed method varies Kn with varying frequency deviation values to obtain the best benefits from RESs, while damping the frequency fluctuations. The proposed method is validated by considering different loading conditions and comparing with other existing studies that consider Kn as a constant value. The simulation results demonstrate that the proposed method, which changes Kn value and subsequently stores the power extracted from the RESs in hydrogen energy storage according to frequency deviation changes, performs better than those that use constant Kn. The statistical analysis for frequency deviation of HGS with the proposed method has the best values and achieves large improvements for minimum, maximum, difference between maximum and minimum, mean, and standard deviation compared to the existing method.
The role of achievement attribution in the associations between parent–child communication and psychological well-being among adolescents: A mediation analysis
Authors: Li Ningning , Li Yuting , Huang Xinxin , Xiang Siying , Hu Qianying , Luo Chao , Ju Peijun , Mellor David , Xu Yifeng , Fei Hui , Chen Jianhua 
Published: August 2022

Abstract

Background
Previous studies have explored the association between parenting style and offspring’s psychological well-being, and the association between offspring’s achievement attribution pattern and psychological well-being. However, little is known about the role of offspring’s achievement attribution in the relationship between parenting and offspring’s psychological well-being. We aimed to find the role of adolescents’ achievement attribution pattern in the relationship between parent–child communication quality and adolescents’ mental health.

Methods
A cross-sectional analysis was conducted on 2,725 adolescents aged from 9 to 18 years who are participating in the China Family Panel Studies. Participants supplied demographic information and completed a series of psychological scales including the Center for Epidemiologic Studies Depression scale, an adapted version of the Parental Bonding Instrument, an achievement attribution scale, and single-item measures of subjective well-being and subjective interpersonal popularity.

Results
Linear regression analysis revealed that after controlling for demographic factors good parent–child communication negatively correlated with depression symptoms, and positively associated with subjective well-being and subjective interpersonal popularity. Next, mediation analysis found that internal attribution of achievement partly mediated the effects of parent–child communication quality on adolescents’ depression, subjective well-being, and subjective interpersonal popularity. The result was robust after controlling demographic variables.

Conclusions
An internal attribution pattern of achievement partially accounted for the associations between parent–child communication quality and adolescents’ psychological outcomes including depression, subjective well-being, and subjective interpersonal popularity. Future interventions for adolescents’ mental health promotion can target parent–child communication and adolescents’ positive achievement attribution pattern.
Genetic Pathways Underlying Individual Differences in Regular Physical Activity
Authors: de Geus Eco J.C. 
Published: August 2022

AbstractTwin and family studies show a strong contribution of genetic factors to physical activity (PA) assessed either by self-report or accelerometers. PA heritability is around 43% across the life span. Genome-wide association studies have implied biological pathways related to exercise ability and enjoyment. A polygenic score based on genetic variants influencing PA could help improve the success of intervention programs.
Recurrent acute hemorrhagic necrotizing encephalopathy associated with RAN-binding protein-2 gene mutation in a pediatric patient
Authors: Olubiyi Olutayo Ibukunolu , Zamora Carlos , Jewells Valerie , Hunter Senyene E. 
Published: August 2022

A young male child presented with recurrent episodes of seizures and altered mental status following febrile episodes on three separate occasions between his first and third birthdays. Laboratory evaluations identified SARS-CoV-2 infection during the first episode and no infective agents or antibodies in the cerebrospinal fluid during all the episodes. Brain imaging with CT and MRI revealed bilaterally symmetric patchy hemorrhagic necrotic foci in the deep brain nuclei and medial temporal lobes, prompting suspicion for an underlying predisposition to recurrent acute hemorrhagic necrotizing encephalopathy. Gene analysis confirmed a mutation in the RAN-binding protein-2 (RANBP2) gene. The patient made good recovery following treatment with IVIG, steroids and plasmapheresis, and follow-up brain imaging showed no progression of brain lesions. Early suspicion from characteristic imaging features in appropriate clinical settings will inform timely appropriate treatment and better outcome. We therefore provided short review of imaging features of acute hemorrhagic necrotizing encephalopathy.