bluuebunny/crossref_metadata_2025_split huggingface dataset:
The consequences of earnings management for the acquisition premium in friendly takeovers
Authors: Missonier‐Piera Franck , Spadetti Cédric 
Published: June 2022

AbstractThis study investigates the effect of earnings management (EM) on deal premiums in friendly takeovers. It examines both accruals and real EM in the year preceding the deal announcement, based on a sample of 578 European firms subject to an acquisition or acquisition attempt between 2005 and 2015. The empirical findings suggest that downward EM is associated with a higher premium offered by the acquirer. The results suggest that income‐decreasing accounting choices could be a negotiated strategy between the acquirer and target firms’ managers to clean the balance sheet, reduce the likelihood of litigation, and create a fictive performance through an accrual reversal post‐acquisition.
Acceptability of using a nasogastric refeeding protocol with adult patients with medically unstable eating disorders
Authors: Matthews‐Rensch Kylie , Young Adrienne , Cutmore Clare , Davis Amanda , Jeffrey Shane , Patterson Susan 
Published: June 2022

AbstractRationale, Aims and ObjectivesNasogastric feeding is becoming commonly used to support patients with medically compromised eating disorders. Previous research has demonstrated the safety of this approach, however there is limited evidence as to how adult patients and staff perceive this feeding method. This study aimed to describe the acceptability of a nasogastric refeeding protocol with adult patients with medically unstable eating disorders and the staff involved in their treatment.MethodThis was a qualitative exploratory study using semi‐structured interviews conducted in acute medical wards of a tertiary hospital where nasogastric nutrition is the sole source of nutrition for the first 7 days of the eating disorder admission. Data were analysed using the Framework method.ResultsEight patients (100% female, median: 22 years old, n = 6 diagnosed with anorexia nervosa) and 12 staff members (medical n = 5, nursing n = 5, dietitians n = 2; median: 8.5 years clinical experience) were interviewed. Patients reported that nasogastric feeding was tolerable, however concerns were raised regarding communication and the desire for concurrent oral feeding. Acceptability from staff was influenced by perceived competence, confidence, tensions around patient‐centred care, and working with stigma and ambivalence.ConclusionsConsideration needs to be given as to whether a ‘nil by mouth’ status during nasogastric feeding further impacts recommencing an oral diet to progress treatment. Improvements are required within the current service, including improved communication, additional educational resources for patients, and allowing patients to partake in decision‐making as able.
System‐Wide Runs and Financial Collapse
Authors: KANG DONGIK 
Published: June 2022

AbstractThis paper presents a model in which small shocks to asset values can trigger system‐wide runs. When lenders cannot distinguish which financial institutions have suffered losses after an adverse shock to asset values, healthier institutions can differentiate themselves from weaker firms by offering to borrow less at more favorable prices. However, to successfully separate, the healthy institutions must liquidate a fraction of their portfolio causing asset fire sales. Fire sales worsen the balance sheet integrity of the firms and, if too severe, this leads to a complete collapse of the financial system: a system‐wide run.
New 1,3,4-oxadiazole compound with effective antibacterial and antibiofilm activity against Staphylococcus aureus
Authors: Dante Formagio M. , de Oliveira Silva J.V. , Fortunato Prohmann L. , Zanetti Campanerut-Sá P.A. , Grenier Capoci I.R. , Seki Kioshima Cotica É. , Graton Mikcha J.M. 
Published: June 2022

Abstract
Staphylococcus aureus is one of the main aetiological agents causing food-borne diseases. Some strains produce enterotoxins responsible for food poisoning. In addition, they can form biofilms on several surfaces such as plastics, glass and stainless steel making it difficult to eliminate them. The present study evaluated, for the first time, the antibacterial and antibiofilm activities of the synthetic compound LMM6 against S. aureus. The minimum inhibitory concentration was 0·97, 1·95 and 1·95 μg ml−1 against S. aureus ATCC 25923, S. aureus 629/94 and S. aureus FRI S-6, respectively. The time-kill curves showed that 96 h treatment with LMM6 reduced approximately 4 log CFU per ml at all tested concentrations. Furthermore, LMM6 reduced S. aureus preformed biofilm by approximately 1 log CFU per cm2. During biofilm formation, a reduction of approximately 4 log CFU per cm2 was observed. LMM6 also reduced biofilm biomass during (~60%) and after biofilm formation (~25 to 45%), as shown by the crystal violet assay. Based on these results, we conclude that LMM6 exhibits antibacterial and antibiofilm activity and may be an innovative synthetic molecule for controlling S. aureus.
Culture media, DMSO and efflux affect the antibacterial activity of cisplatin and oxaliplatin
Authors: Gupta A. , Bernacchia L. , Kad N.M. 
Published: June 2022

Abstract
Cisplatin was originally discovered through its antibacterial action and subsequently has found use as a potent broad-spectrum anticancer agent. This study determines the effect of growth media and solvent on the antibacterial activity of cisplatin and its analogue, oxaliplatin. Escherichia coli MG1655 or MG1655 ΔtolC was treated with the platinum compounds under different conditions and susceptibility was determined. Our results showed that DMSO reduced the activity of cisplatin by fourfold (MIC 12·5 mg l−1) compared with 0·9% NaCl-solubilized cisplatin (MIC 3·12 mg l−1) when tested in MOPS. Surprisingly, complete loss of activity was observed in Mueller–Hinton Broth II (MHB II). By supplementing MOPS with individual components of MHB II such as the sulphur-containing amino acids, l-cysteine and l-methionine, individually or in combination reduced activity by ≥8-fold (MIC ≥25 mg l−1). Oxaliplatin was less active against E. coli (MIC 100 mg l−1) but exhibited similar inactivation in the presence of DMSO, MHBII or MOPS spiked with l-cysteine and l-methionine (MIC ≥400 mg l−1). Our data suggest that the antibacterial activity of cisplatin and oxaliplatin is modulated by both choice of solvent and composition of growth media. We demonstrate that this is primarily due to sulphur-containing amino acids cysteine and methionine, an essential component of the recommended media for testing antimicrobial susceptibility, MHBII.
The role of radiology in risk assessment and management of oroantral fistula and displaced roots
Authors: Bell Garmon , Donaldson Kirstyn , Hopkins Claire 
Published: June 2022

AbstractThere is a weak evidence base on which to define the most appropriate radiographic technique to evaluate dental tissues that may impact on the maxillary sinus, including the risk assessment for oroantral communications, identification and removal of displaced roots, timing and optimal management of oroantral fistula, in the presence of odontogenic sinusitis. There is no demonstrable benefit from the routine use of CBCT in exodontia. However, cross‐sectional imaging is strongly recommended over 2‐dimensional radiographic techniques when identifying displaced roots of teeth, and during surgical management of oroantral fistulae, particularly when considering the incidence of extra‐maxillary disease in odontogenic sinusitis. In this narrative review, using the limited evidence available, and relying on clinical experience, we adopt a risk–benefit analysis for the optimal use of various radiographic imaging modalities from pre‐operative assessment to management of complications, focusing on patient outcomes.
A case of synchronous malignant tumours in a parotid gland
Authors: Hankinson Paul Michael , Karbhari Bhavesh , Allsobrook Olive , Nusrath Muzzammil , Khurram Syed Ali 
Published: June 2022

AbstractSynchronous unilateral tumours within the parotid gland of differing histological type are rare, accounting for less than 1% of parotid gland neoplasms. Here we present a case of a primary tumour of the parotid gland alongside a synchronous metastasis at the same site, highlighting the diagnostic and treatment challenges present, especially where a core biopsy is unable to sample the multiple tumour types. Though rare multiple tumour types must be kept in the differential diagnosis of multifocal salivary gland disease.
Perialar intertrigo in children and adolescents: A multicenter prospective study of 41 cases
Authors: Sanchez Adrien , Mahe Emmanuel , Miquel Juliette , Abasq Claire , Phan Alice , Mazereeuw‐Hautier Juliette , Lemille Juliette , Maruani Annabel , Bonniaud Bertille , Plantin Patrice , Mallet Stéphanie , Martin Hélène , Hubiche Thomas , Chiaverini Christine , Lacour Jean‐Philippe ,   Groupe de Recherche de la Société Française de Dermatologie Pédiatrique
Published: June 2022

AbstractBackground/ObjectivesWe observed isolated cases of perialar intertrigo in children and teenagers that did not appear to correspond to any known clinical entity. The objective of this study was to describe the clinical features of this dermatosis and the clinical characteristics of the patients.MethodsWe conducted a prospective, multicenter cohort study in France from August 2017 to November 2019. All the patients under 18 years of age with chronic perinasal intertrigo were included. A standardized questionnaire detailing the clinical characteristics of the patients and the description of the intertrigo. If possible, a Wood's lamp examination of the intertrigo was done.ResultsForty‐one patients were included (25 boys and 16 girls, average age: 12.1 years). Intertrigo was bilateral in 38 patients (93%). The majority of patients had no symptoms (54%). Pruritus was present in 39% of cases. Orange red follicular fluorescence was present in the perialar region on Wood's light examination in 78% of cases with active fluorescence. The presumptive diagnoses suggested by the investigators were acne (24.4%), seborrheic dermatitis (19.5%), rosacea (9.8%), psoriasis (9.8%) and perioral dermatitis (7.3%). No diagnosis was proposed in 22% of the cases.ConclusionsWe describe a previously undescribed clinical sign which is characterized by a chronic bilateral erythematous intertrigo located in the perialar region. It can be isolated or associated with various facial dermatoses.
High‐grade transformation of pancreatic neuroendocrine tumor associated with TP53 mutations: A diagnostic pitfall mimicking neuroendocrine carcinoma
Authors: Tanaka Mariko , Shinozaki‐Ushiku Aya , Kunita Akiko , Yasunaga Yoichi , Akamatsu Nobuhisa , Hasegawa Kiyoshi , Ushiku Tetsuo 
Published: June 2022

AbstractAmong pancreatic neuroendocrine neoplasms, mutations in ATRX, DAXX, and MEN1 are specific to neuroendocrine tumors (NETs), whereas TP53 and RB1 mutations are characteristic of neuroendocrine carcinomas (NECs). We report a case of pancreatic NET that underwent high‐grade transformation associated with acquisition of TP53 mutations. The primary pancreatic tumor consisted of conventional grade 2 NET with loss of alpha‐thalassemia/mental retardation, X‐linked expression and wild‐type TP53, with a small focus exhibiting significant pleomorphism and increased mitotic activity of the neoplastic cells with two pathogenic TP53 mutations. Two years later, multiple liver metastases developed and were surgically resected. The metastatic tumors showed marked pleomorphism with increased mitotic activity (17/2 mm2) and TP53 mutations identical to the small area with TP53 mutations in the primary tumor. Liver metastases with a single TP53 mutation were also noted. Notably, hormonal phenotype has changed during progression with decreased glucagon and increased insulin expression in the metastases. Our observations suggest that TP53 mutation can occur in pancreatic NETs during progression and can be associated with phenotypic transformation. Importantly, increased pleomorphism, mitotic activity, as well as TP53 mutations could be diagnostic pitfalls leading to an overdiagnosis of NEC.
Arabidopsis ABCG27 plays an essential role in flower and leaf development by modulating abscisic acid content
Authors: Kim Kyungyoon , Choi Bae Young , Kang Joohyun , Shim Donghwan , Martinoia Enrico , Lee Youngsook 
Published: June 2022

AbstractAbscisic acid (ABA) is a phytohormone that mediates stress responses and regulates plant development. Several ATP‐binding cassette (ABC) transporters in the G subfamily of ABC (ABCG) proteins have been reported to transport ABA. We investigated whether there are any other ABCG proteins that mediate plant developmental processes regulated by ABA in Arabidopsis (Arabidopsis thaliana). The ABCG27 gene was upregulated in response to exogenous ABA treatment. The abcg27 knockout mutant exhibited two developmental defects: epinastic leaves and abnormally long pistils, which reduced fertility and silique length. ABCG27 expression was induced threefold when flower buds were exposed to exogenous ABA, and the promoter of ABCG27 had two ABA‐responsive elements. ABA content in the pistil and true leaves were increased in the abcg27 knockout mutant. Detached abcg27 pistils exposed to exogenous ABA grew longer than those of the wild‐type control. ABCG27 fused to GFP localized to the plasma membrane when expressed in Arabidopsis mesophyll protoplasts. A transcriptome analysis of the pistils and true leaves of the wild type and abcg27 knockout mutant revealed that the expression of organ development‐related genes changed in the knockout mutant. In particular, the expression of trans‐acting small interference (ta‐si) RNA processing enzyme genes, which regulate flower and leaf development, was low in the knockout mutant. Together, these results suggest that ABCG27 most likely function as an ABA transporter at the plasma membrane, modulating ABA levels and thereby regulating the development of the pistils and leaves under normal, non‐stressed conditions.
Gene editing in porcine embryos using a combination of electroporation and transfection methods
Authors: Takebayashi Koki , Wittayarat Manita , Lin Qingyi , Hirata Maki , Yoshimura Naoaki , Torigoe Nanaka , Nagahara Megumi , Do Lanh Thi Kim , Tanihara Fuminori , Otoi Takeshige 
Published: June 2022

AbstractCRISPR/Cas9 (clustered regularly interspaced short palindromic repeats‐CRISPR‐associated protein 9) technology is growing rapidly and has been greatly influencing the efficiency and effectiveness of genetic modifications in different applications. One aspect of research gaining importance in the development of the CRISPR/Cas9 system is the introduction of CRISPR materials into target organisms. Although we previously demonstrated the efficacy of electroporation‐ and lipofection‐mediated CRISPR/Cas9 gene disruption in porcine zygotes, we still believe that the efficiency of this system could be improved by combining these two methods. The present study was thus conducted to clarify the effects of a combination of electroporation and lipofection for delivering CRISPR/Cas9 components into zona pellucida (ZP)‐intact and ‐free zygotes. The results revealed that electroporation alone significantly increased the biallelic mutation rates in the resulting blastocysts compared to lipofection alone, irrespective of the presence of ZP. None of ZP‐intact zygotes treated by lipofectamine alone had any mutations, suggesting that removal of the ZP is necessary for enabling CRISPR/Cas9‐based genome editing via lipofection treatment in the zygotes. Additional lipofectamine treatment after electroporation did not improve the rates of total and biallelic mutations in the resulting blastocysts derived from either ZP‐intact or ‐free zygotes.
The prospect of targeting T cell immunoglobulin and mucin‐domain containing‐3 in renal cell carcinoma immunotherapy
Authors: Mohsenzadegan Monireh , Nowroozi Mohammad Reza , Fotovvat Amirreza , Bavandpour Baghshahi Parizad , Bokaie Saied , Inanloo Seyed Hassan , Sharifi Laleh 
Published: June 2022

AbstractDespite the advances in the diagnosis and treatment of renal cell carcinoma (RCC), it remains one of the most deadly urological cancers. At present, using immune checkpoint inhibition and their combination with antiangiogenic therapy is the standard of care in patients with advanced RCC. Unfortunately, a considerable part of tumour‐bearing hosts does not benefit from this type of treatment. However, our knowledge about the detailed role of mucin‐domain containing‐3 (TIM‐3) in the RCC cells is little, and further studies are required in this field, but its significant expression in the RCC microenvironment makes this receptor a promising target for designing new monoclonal antibodies alone or in combination with other checkpoint inhibitors for RCC immunotherapy.
Impact of societal and legal context on the blood supply of African‐ancestry populations in Western countries: A review of practices and the French example
Authors: Oviedo Pauline , Jaffré Yannick , Danic Bruno , Mazières Stéphane , Chiaroni Jacques 
Published: June 2022

AbstractIn Western countries, blood supply agencies encounter impediments in providing blood groups defined as rare or of interest, notably for sub‐Saharan African ancestry (SSAA) recipients. To establish warning levels and anticipate future blood needs, an estimate of the current carriers of rare blood groups, both potential patients or donors, is crucial but complex. Indeed, if the strict needs can be estimated in medical terms, the modalities of blood product collection must be considered from an interdisciplinary perspective, at the interface of biological data and social norms. Here, we aim to understand how legal choices and a set of representations of otherness may influence the supply of rare blood for SSAA populations. After examining these issues, considering different norms and limits that govern French society, we compare this data with those of four Western countries facing the same difficulties (United States, United Kingdom, Italy and the Netherlands). This work began as part as the reflections of Social Lab, an institutional programme created by the French Blood Establishment (EFS). How can we effectively improve the qualitative blood coverage for SSAA populations? There is no unique solution, but there are many more or less effective answers. Comparison across countries reveals a strong influence of the socio‐political histories and ethical choices before technical and medical considerations. We consider that an institutional policy is required to resolve recruitment issues of SSAA donors sustainably. Lastly, we introduce a working group called the EFS Social Lab, which aims to set up a monitoring mechanism for donors and societal trends to make blood donation effective.
A Third-Order Two-Stage Numerical Scheme for Fractional Stokes Problems: A Comparative Computational Study
Authors: Nawaz Yasir , Arif Muhammad Shoaib , Abodayeh Kamaleldin 
Published: June 2022

Abstract
A third-order numerical scheme is proposed for solving fractional partial differential equations (PDEs). The first explicit stage can converge fast, and the second implicit stage is responsible for enlarging the stability region. The fourth-order compact scheme is employed to discretize spatial derivative terms. The stability of the scheme is given for the standard fractional parabolic equation, whereas convergence of the proposed scheme is given for the system of fractional parabolic equations. Mathematical models for heat and mass transfer of Stokes first and second problems using Dufour and Soret effects are given in a set of linear and nonlinear PDEs. Later on, these governing equations are converted into dimensionless PDEs. It is shown that the proposed scheme effectively solves the fractional forms of dimensionless models numerically, and a comparison is also conducted with existing schemes. If readers want it, a computational code for the discrete model system suggested in this paper may be made accessible to them for their convenience.
Reusable Proline-Containing Bimetallic Pd–Ni(Co, Cu, Fe)–Pro/Al2O3 Catalysts for Suzuki Reaction in Water
Authors: Bumagin N. A. 
Published: June 2022

Abstract
Bimetallic proline-containing composites Pd–Ni(Co, Cu, Fe)–Pro/Al2O3, due to the synergistic effect, exhibit high catalytic activity in the Suzuki reaction in aqueous media, which makes it possible to reduce the amount of expensive Pd to 10–2 mol %. New catalysts are easily regenerated from the reaction mixture and can be reused up to 5 times without losing activity.
Qualitative analysis of the organisational response of a university hospital during the first wave of the COVID-19 crisis
Authors: Harkouk Hakim , Castel Patrick , Hervouët Lucile , Fletcher Dominique 
Published: June 2022

BackgroundThe COVID-19 pandemic has required urgent organisational and managerial adaptation, with hospital medical and administrative leaders under considerable pressure.MethodsAt a single French university hospital, we performed a sociological analysis of management adaptation by medical and administrative leaders during the first wave of the COVID-19 crisis. Two sociologists performed interviews with representative members of staff from all the structures involved in managing the crisis to analyse adaptation and the solutions found during this period.ResultsThe answers collected during interviews were classified into three main topics describing the organisational adaptations of the hospital staff during the COVID-19 crisis: (1) exceptional mobilisation and collaboration; (2) crisis management based primarily on the principle of subsidiarity; and (3) survival of the administrative structure with interventions to support caregivers.ConclusionThis study, focusing on a single hospital, identified a number of factors associated with successful mobilisation in the very specific conditions of this viral pandemic.