bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoformulation, Chracterization and In vivo Pharmacokinetic Studies of Diosgenin and Emodin-loaded Polymeric Nanoparticles
Authors: Sherekar Prasad , Suke Sanvidhan , Dani Ragini , Mangrulkar Shubhada , Dhok Archana 
Published: December 2022

Abstract
Obstruct pharmacokinetics and low bioavailability of diosgenin (DG) and emodin (ED) are major limitations for their therapeutic success in several inflammatory diseases. Nanoencapsulation of both drugs will promisingly overcome these limitations. Herein, polylactic-co-glycolic acid (PLGA) was used for nanoformulation of diosgenin and emodin-loaded PLGA nanoparticle (DGn and EDn) via modified solvent-emulsion-diffusion-evaporation method. Functional stability of prepared nanoparticles and in vitro physiological characterization including mean particle sizes distribution, polydispersity index, surface zeta potential, and morphological examinations were performed. Moreover, drug loading and encapsulation efficiency were also evaluated by measuring drug concentration through spectroscopy and HPLC method. Both drug nanoformulations demonstrated functional drug stability, 200─270 nm sizes with homogeneous particle distribution, negative surface zeta potential stability, and uniform spherical morphology. Moreover, nanoparticles showed in vitro controlled drug release pattern over 24 hours with 40─70% of drug depletion. Pharmacokinetics analysis was performed on sixteen rats equally distributed in four groups (DG, ED, DGn, and EDn). Pure drugs and nanoformulations were orally (10 mg/kg) administrated to animal model, and pharmacokinetic profiles of both drugs were evaluated. PLGA nanoparticles were significantly able to alter the pharmacokinetics of DG, while little improvement was observed for ED. Consequently, changes in pharmacokinetics of both drugs are attributed to size and surface characteristics of nanoparticles. DGn and EDn subsidize increased mean plasma residence time and maximize area under curve with decreased drug clearance rate. Resulting in vitro characteristics and in vivo pharmacokinetics data reveal the efficacy of DGn and EDn to be suitable nano-drug delivery modalities with improved bioavailability and pharmacological strength.
Self-sexualization in Relation to Sexual Harassment and Body Shame
Authors: Choi Dooyoung , Kang Ju-Young M. , Kim Jieun , Lee Ha Kyung 
Published: December 2022

AbstractWhile many researchers examined several harmful consequences of the imposed or forced sexualization of women, still little is known about voluntary self-sexualization and its potential effects on women who engage in the practice. Although the idea that self-sexualization is self-fulfilling remains contentious, women who self-sexualize are naturally expected to receive sexualized attention, including unwanted attention. This study starts with the question of whether self-sexualizing women, including those who use self-sexualization as a source of power, experience sexual objectification, measured by nonphysical sexual harassment, and its negative consequence, measured by body shame. Furthermore, we investigate how age moderates the relationship. An online questionnaire was created and a total of 308 women completed the questionnaire. Structural equation modeling was conducted to test the hypothesized causal relationships from self-sexualization (self-empowering sexualization and no-power-intent self-sexualization) to nonphysical sexual harassment, which can lead to body shame. The results showed that the effects of self-sexualization are dependent on the intent for self-sexualization as well as the self-sexualizer’s age. While self-sexualization without intent to gain power can lead to increased sexual harassment incidents and body shame, mature women’s self-sexualization as a source of power does not lead to increased sexual harassment experiences nor increased body shame. However, unlike the mature women’s self-empowering sexualization, the young women’s self-sexualization, with or without intent to gain power, can lead to more sexual harassment experiences. The findings of this study indicate the need to uncover the various intentions for self-sexualization as well as their different effects.
Spectral Geometry and Riemannian Manifold Mesh Approximations: Some Autocorrelation Lessons from Spatial Statistics
Authors: Griffith Daniel 
Published: December 2022

Abstract

Awareness of the utility of spectral geometry is permeating the academy today, with special interest in its ability to foster interfaces between a range of analytical disciplines and art, exhibiting popularity in, for example, computer engineering/image processing and GIScience/spatial statistics, among other subject areas. This paper contributes to the emerging literature about such synergies. It more specifically extends the 2-D Graph Moranian operator that dominates spatial statistics/econometrics to the 3-D Riemannian manifold sphere whose analysis the Graph Laplacian operator monopolizes today. One conclusion is that harmonizing the use of these two operators offers a way to expand knowledge and comprehension.
Investigation of linear and non-linear functional connectivity within resting-state networks using graph theory in Parkinson's disease
Authors: Ahmadimehr Shakiba 
Published: December 2022

Abstract
Purpose
Parkinson's disease (PD) is widely known as a neurodegenerative disorder of the nervous system for which there is no cure. Accordingly, researchers can utilize neuroimaging techniques like functional magnetic resonance imaging (fMRI) to investigate neural activities in the brain non-invasively. Most previous research works construct brain graphs based on linear correlations for functional connectivity (FC) analysis. In this study, we compared linear and nonlinear functional connectivity methods.
Methods
The objective of our study is to implement 5 functional connectivity methods on 14 resting-state fMRI networks (RSNs) based on the FIND RSN template that is divided into 90 regions. Kernel Mutual information (KMI), a unique nonlinear connectivity approach based on Mutual information (MI), is also employed. Consequently, the validity of the methods was assessed using local graph measures and statistical analysis.
Results
The results show that nonlinear methods outperformed linear ones using the outcome of graph theory. In the non-linear functional connectivity methods, all seven graph measures showed a significant difference between two groups: healthy control (HC) and Parkinson's disease (PD), but only one graph measure showed a significant difference in the linear functional connectivity methods. Furthermore, while K-Corenness centrality has been utilized in previous studies to diagnose and assess various neurodegenerative illnesses, it is employed for the first time in our study to diagnose Parkinson's patients using fMRI data.
Conclusions
According to the findings of this study, nonlinear functional connectivity should be investigated in Parkinson's disease and other neurodegenerative diseases.
Generation of human haploid neural stem cells from parthenogenetic embryonic stem cells
Authors: Wang Haisong , Ma Xinrui , Niu Wenbin , Shi Hao , Liu Yidong , Ma Ningzhao , Zhang Nan , Sun Ying-Pu 
Published: December 2022

AbstractRecently, haploid embryonic stem cells (haESCs) have been established in many species and widely used in forward and reverse genetic screening. Differentiated haploid cell line types in mammals are lacking due to spontaneous diploidization during differentiation that compromises lineage-specific screens. Human embryonic stem cells are widely used in basic and preclinical research. In this work, we report that human haESCs in extended pluripotent culture medium showed more compact colonies, higher efficiency in neural differentiation, and higher stability in haploidy maintenance, which effectively facilitated the derivation of haNSCs. Human haploid neural stem cells (haNSCs) can be generated by differentiation and maintain haploidy and multipotency to neurons and glia in the long term in vitro. After PiggyBac transfection, there were multiple insertion sites in the haNSC genome and the insertion sites evenly spread across all chromosomes. This is the first human haploid somatic cell line with a complete genome, proliferative ability and neural differentiation potential, which provides cell resources for recessive inheritance and drug targeted screening.
Reprocessing 2-D Airgun Seismic Reflection Data SALTFLU (Salt Deformation And Sub-Salt Fluid Circulation In The Algero-Balearic Abyssal Plain) In the Balearic Promontory and the Algerian Basin
Authors: Blondel Simon , Ford Jonathan , Lockwood Aaron , Ben Anna Del , Camerlenghi Angelo 
Published: December 2022

Abstract
In an ever more challenging context for the acquisition of seismic data in the Mediterranean Sea, reprocessing to improve the quality of legacy data has become increasingly important. This work presents the newly reprocessed, open access dataset SALTFLU acquired in the Algerian basin by the National Institute of Oceanography and Applied Geophysics (OGS) in 2012. We apply a ‘broadband’ reprocessing strategy adapted for offset-limited (3km streamer for a target 4 km below the sea level) airgun reflection seismic data acquired in deep water settings. We then assess if the reprocessed images provide new geological insights on the Mediterranean sub-surface. The workflow relies on an integrated approach combining geophysics and geological interpretation to iteratively build the velocity model. In this way we aim to tackle some of the challenges linked to imaging deep complex geological structures containing high velocity contrasts with 2-D, offset-limited seismic data. We first broaden the bandwidth of the data through multi-domain de-noising, deghosting and a source designature using an operator derived from the seabed reflection. We then perform iterative migration velocity analysis, pre-stack time migration and multiple attenuation in the Radon domain to obtain time-migrated images. The initial velocity model is derived from the resulting time migration velocities, and geologically driven model updates are generated using a combination of travel-time tomography, seismic interpretation of the major salt horizons and velocity gradient flooding. The gradient flooding aims to reproduce the large scale first-order velocity variations, while the travel-time tomography aims to resolve the smaller second-order velocity variations. The results improve our deep geological knowledge of the under-explored Algerian basin down to the base salt and the pre-salt. Fluid indicators are imaged within the Plio-Quaternary of the Algerian basin, which we interpret as thermogenic or biogenic gas sourced from either the Messinian Upper Unit or from the pre-salt, migrating through a hydro-fractured salt. The reprocessed data image lateral and vertical seismic facies variation within the Messinian units that could shed new light on the tectono-stratigraphic processes acting during the Messinian Salinity Crisis. It also reveals numerous previously unresolved volcanic structures within the Formentera basin.
Dynamic 3D Network Design for UAV Based Photogrammetry in mountainous terrain
Authors: Gargari Ali Mahdinezhad , Ebadi Hamid , Esmaeili Farid , Latifzadeh Sahar 
Published: December 2022

Abstract
Topographic mapping in mountainous areas encounters many challenges due to the potential impasse and lack of access to all locations. Unmanned Aerial Vehicles (UAVs) are an effective alternative to traditional field mapping in different environmental conditions. However, problems such as large-scale differences, gaps, and errors due to extreme elevation differences in these areas, hinders the use of UAV-based photogrammetry, thus reducing the quality and accuracy of the photogrammetric products and the final extracted map in mountainous areas. By designing an optimal flight network before UAV acquisition, the effect of these problems can be reduced. This paper proposes a method for planning the dynamic three-dimensional Imaging Network UAV in mountainous terrain based on digital elevation model (DEM) to ensure the uniformity of the scale in the photogrammetric blocks, avoid collision with obstacles, also gaps or data redundancy. The proposed method was implemented in a semi-mountainous area and the results showed that the large-scale changes among the images were reduced and the GSD was maintained as constant as possible. Also, planning UAV flight program based on the proposed algorithm increases the accuracy of the photogrammetric products.
Anti-obesity effect of the bacterial product, nisin
Authors: Al-Emarah Muslim , Kazerani Hamid Reza , Taghizad Fereidoun , Dehghani Hesam , Elahi Mohammad 
Published: December 2022

Abstract
Obesity is one of the most important metabolic disorder that predisposes individuals to other diseases. We investigated the effect of nisin, a bacteriocin produced by some bacteria, on obesity and some of its related parameters. Forty mice were randomly divided into four groups and received a placebo (saline) or nisin (25, 50, or 100 µg/kg, ip), daily, for 8 weeks. Bodyweight and food intake were measured weekly, and at the end of the experiment, the levels of fasting blood sugar, serum triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein, and hepatic enzymes were tested, and red and white blood cell counts, haemoglobin concentration, mean corpuscular volume, mean corpuscular haemoglobin, and mean corpuscular haemoglobin concentration were determined. Finally, the expression levels of some obesity-related genes, including stearoyl-CoA desaturase-1 (SCD-1), glucose transporter-4 (GLUT4), zfp423, 422(ap2), and tumor necrosis factor-alpha (TNF-α) were assessed using RT-qPCR. After the experiment, the body weights, abdominal fat, and body mass index were significantly lower in the nisin-treated groups than in the control. The highest effect was observed with 50 µg/kg of nisin, and this dose caused a significant reduction in the total food intake. The expression of SCD-1, GLUT4, 422(ap2), and TNF-α decreased significantly following treatment with nisin. No significant differences were observed in the other studied parameters, and no toxic effects were observed for nisin under these experimental conditions. Our results suggest that nissin could have weight-protective effects.
Cobalt-based metalloporphyrins as efficient electro-catalysts for hydrogen evolution from acetic acid and water
Authors: Wang Zong , Liu Yin , Li Ting , He Yong-Zhen , Chen Yan-Lin , Jiang Xin-Yi , Ni Chun-Lin , Yang Le-Min , Liu Wei 
Published: December 2022

Abstract
Four molecular electrocatalysts based on cobalt complexes, CoT(X)PP (X = H (1), OH (2), CN (3), COOH (4)), were prepared from meso-tetra-p-X-phenylporphin (H2T(X)PP, X = H, OH, CN, COOH) by reaction with cobalt acetate to be used for electrolytic proton or water reduction. The electrochemical properties and the corresponding catalytic activities of these four catalysts were investigated by cyclic voltammetry. Controlled potential electrolysis with gas chromatography analysis confirmed that the turn-over frequencies (TOF) per mol of catalyst per hour were 42.4, 38.6, 55.5, and 70.1 mol H2 at an overpotential of 941.6 mV (in DMF) in the acetic acid solution containing catalyst. In neutral buffered aqueous solution (pH 7.0), these four molecular catalysts had TOF per mol of catalyst per hour of 352.53, 313.7, 473.4, and 714.6 mol H2, respectively, with an overpotential of 837.6 mV, indicating that complex 4 had better activity than complexes 1, 2, and 3. The Faraday efficiencies of complexes 1–4 were 99.1, 99.6, 100.4, and 99.0% at 72 h of consecutive reduction on a glassy carbon electrode, respectively. These results indicate that the electronic properties of the ligands play a crucial role in determining the catalytic activity of the cobalt complex and are consistent with the phenomenon that the catalytic activity of the benzene porphyrins is significantly increased in the presence of electron-withdrawing groups, and the CoT(COOH)PP is the most active catalyst.
Rigid-flexible-thermal coupling dynamics of hub and multi-plate system considering frictional contact
Authors: Yuan Tingting , Lei Bo , Liu Jinyang , Wu Yunli 
Published: December 2022

Abstract
A geometric nonlinear modeling approach for strong rigid-flexible-thermal coupling dynamics of the hub and multi-plate system considering frictional contact is proposed. Based on the absolute nodal coordinate formulation (ANCF), a thermal integrated ANCF thin plate element is developed, where the temperature field is expressed with Taylor polynomials to yield two-dimensional heat conduction equations. Different from the traditional coupling formulations, the influences of the attitude motion and structural deformation on the intensity of the solar radiation, the geometric nonlinearity of the plate as well as the frictional contact are taken into account. The normal contact is formulated by the penalty method, and the tangential friction considers the stick–slip transition. To solve the strong rigid-flexible-thermal coupling equations, a novel numerical method combining the modified central difference approach and the generalized-a method is proposed. Two validations are performed to verify the proposed thermal-structural coupling model, which proves the importance of the geometric nonlinearity and can capture the thermally induced vibration. Then the thermal-dynamic coupling analysis for the satellite and solar array multibody system in thermal environment is carried out. The dynamic characteristics of the thermally induced vibration can be successfully revealed by the rigid-flexible-thermal coupling model. Furthermore, it is indicated that the influence of contact and thermal load on the nonlinear behavior of the solar array deployment is essential, which demonstrates the feasibility of the proposed approach.
Photonic higher-order topological insulator with enlarged non-trivial bandgaps
Authors: Zhang Yuexin , Dai Xiaoyu , Xiang Yuanjiang 
Published: December 2022

Abstract
Recently, the emergence of higher-order topological insulators (HOTIs) has drawn extensive investigations. The unconventional bulk-hinge correspondence featuring in-gap corner or hinge states have been observed in diversified platforms like acoustics and photonics. However, three-dimensional (3D) photonic HOTIs are less attached due to the complicated properties of electromagnetic (EM) waves and narrow photonic bandgaps. In this article, we propose a photonic HOTI with a simple multilayer structure to support hinge states. By inserting a central metallic pillar in the unit cell, the 3D bandgap can be extended to 17.9%, allowing for pure and distinguishable surface and hinge modes. Free from adjusting the distance between adjacent dielectric rods to construct a topological interface, the lattice distortions can be achieved by controlling the geometrical length of sub-lattices, which providing a reconfigurable and flexible scheme to realize the robust hinge and surface wave transmission. Our findings usher the door for high-performance topological optical apparatus with efficient one-way light propagation and energy concentration.
High-performance IN738 superalloy derived from turbine blade waste for efficient ethanol, ethylene glycol, and urea electrooxidation
Authors: Hefnawy Mahmoud A. , Medany Shymaa S. , El-Sherif Rabab M. , El-Bagoury Nader , Fadlallah Sahar A. 
Published: December 2022

Abstract
In this work, the IN738 superalloy used previously in gas turbines was recycled and used as a working electrode for the electrooxidation of different fuels, namely, ethylene glycol, ethanol, and urea. The electrocatalytic efficiency of the electrode was studied by cyclic voltammetry, chronoamperometry, and electrochemical impedance. Several kinetics parameters like diffusion coefficient, Tafel slope, rate constant, and activation energy were calculated. The modified electrode was characterized as received using XRD, SEM, and EDAX to elucidate the crystal structure and surface morphology before and after electrochemical oxidation. The anodic current densities of electrochemical oxidation of ethanol, ethylene glycol, and urea were 29, 17, and 12 mA.cm-2, respectively, in an alkaline solution at a potential 0.6 V (vs. Ag/AgCl). The kinetic parameters like diffusion coefficients for ethanol, ethylene glycol, and urea were equaled to 1.5 10-6, 1.03810-6, and 0.6410-6 cm2 s-1. The charge transfer resistances were estimated for electrooxidation of different fuels by electrochemical impedance (EIS).
Dissemination of metallo-β-lactamase-producing Pseudomonas aeruginosa in Serbian hospital settings: expansion of ST235 and ST654 clones
Authors: Kabic Jovana , Fortunato Gianuario , Vaz-Moreira Ivone , Kekic Dusan , Jovicevic Milos , Pesovic Jovan , Ranin Lazar , Opavski Natasa , Manaia Célia M. , Gajic Ina 
Published: December 2022

Abstract
Background: Pseudomonas aeruginosa is one of the most common nosocomial pathogens worldwide. Limited information on beta-lactamase-producing P. aeruginosa in Serbia is available. The aim of this nationwide study was to investigate the molecular characteristics of metallo-β-lactamase (MBL)-producing P. aeruginosa in Serbia, to characterize underlying resistance mechanisms, to analyze the genetic context of detected MBL genes and clonal relationship between isolates harboring genes encoding MBL.
Methods: A total of 320 isolates of P. aeruginosa were identified out of 5334 bacterial isolates collected from 2018 to 2021. Carbapenem-resistant P. aeruginosa (CRPA) were screened for the presence of blaVIM, blaIMP, and blaNDM, genes whereas MBL-positive isolates were tested for the presence of the genes blaCTX-M-2, blaPER, blaTEM, blaSHV, blaVEB, and blaGES. Multilocus sequence typing and phylogenomic analysis were performed for P. aeruginosa producing MBL.
Results: P. aeruginosa isolates were recovered from the lower respiratory tract (n=120; 37.5%), wound specimens (n=108; 33.75%), and urine samples (n=71; 22.2%), mainly from patients admitted to the intensive care unit (n=178; 55.6%). CRPA isolates accounted for 43.1% (n=138) of the tested P. aeruginosa and 31 out of these were blaNDM-1-positive (22.5%). Colistin was the most effective antibiotic, with a resistance rate of 0.3%. MLST analysis of all blaNDM-1-positive isolates (n=31) revealed the occurrence of ST235 (n=25) and ST654 (n=6), mostly confined to Serbia. The distribution of beta-lactamase encoding genes in these isolates suggested clonal dissemination and possible recombination: ST235/blaNDM-1, ST235/blaNDM-1/blaPER-1, ST654/blaNDM-1, ST654/blaNDM-1/blaPER-1, and ST654/blaNDM-1/blaGES-5.
Conclusions: High-risk clones ST235 and ST654 identified for the first time in Serbia, are important vectors of acquired MBL and ESBL in Serbia and their associated multidrug resistance (MDR) phenotypes represent a cause for considerable concern.