bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping Earthquake Risk Sensitivity of Land Use Plan at Local Level for Sustainable Risk Sensitive Land Use Planning (RSLUP)
Authors: Barua Uttama , Ansary Mehedi Ahmed , Islam Ishrat 
Published: January 2022

Abstract
Risk-Sensitive Land Use Planning (RSLUP) is the process of mainstreaming disaster risk management parameters in land use planning. To ensure the effectiveness and sustainability of RSLUP, it is necessary to identify and understand the existing risk sensitivity of the land use plan. This research aims to develop a GIS-based multi-criteria zoning approach for mapping earthquake risk sensitivity of the land use plan of a local level area. For this purpose, Uttara Residential Model Town (URMT) (third phase), Dhaka, Bangladesh has been selected as the study area considering its earthquake risk for exposure to a potential earthquake. The methodology applied in this research is comprised of two steps. Firstly, assessment of the spatial earthquake risk sensitivity of the proposed land use plan of the study area based on the risk themes and corresponding risk attributes including both natural characteristics as well as built environment factors. They are macro-form risks (seismic hazard assessment), risks in urban texture (proximity from primary roads), special risk areas (geomorphic suitability and proximity from waterbody), open space scarcity risk, and risks in critical facilities (potential temporary disaster shelter and health facilities). Secondly, preparation of earthquake risk sensitivity zoning map by overlaying the spatial risk attribute maps based on weights determined through Analytical Hierarchical Process (AHP). This research brings out the importance and a methodology to assess risk sensitivity of the land use of an area at the local level, which can further foster sustainable RSLUP reflecting the risk sensitivity accordingly and effectively.
Prenatal and Early-Life Environmental Factors, Family Demographics and Cortical Brain Anatomy in 5-Year-Olds: An MRI Study From FinnBrain Birth Cohort
Authors: Silver Eero , Pulli Elmo P. , Kataja Eeva-Leena , Kumpulainen Venla , Copeland Anni , Saukko Ekaterina , Saunavaara Jani , Merisaari Harri , Lähdesmäki Tuire , Parkkola Riitta , Karlsson Linnea , Karlsson Hasse , Tuulari Jetro 
Published: January 2022

Abstract
The human brain develops dynamically during early childhood, when the child is sensitive to both genetic programming and extrinsic exposures. Recent studies have found links between prenatal and early life environmental factors, family demographics and the cortical brain morphology in newborns measured by surface area, volume and thickness. Here in this magnetic resonance imaging study, we evaluated whether a similar set of variables associates with cortical surface area and volumes measured in a sample of 170 healthy 5-year-olds from the FinnBrain Birth Cohort Study. We found that child sex, maternal pre-pregnancy body mass index, 5min APGAR score, neonatal intensive care admission and maternal smoking during pregnancy associated with surface areas. Furthermore, child sex, maternal age and maternal level of education associated with brain volumes. Expectedly, many variables deemed important for neonatal brain anatomy (such as birth weight and gestational age at birth) in earlier studies did not associate with brain metrics in our study group of 5-year-olds, which implies that their effects on brain anatomy are age-specific. Future research may benefit from including pre- and perinatal covariates in the analyses when such data are available. Finally, we provide evidence for right lateralization for surface area and volumes except for the temporal lobes. These subtle differences between hemispheres are variable across individuals and may be interesting brain metrics in future studies.
Carrier-Free Multifunctional Nanomedicine For Intraperitoneal Disseminated Ovarian Cancer Therapy
Authors: Huang Xiuyu , Qiu Miaojuan , Wang Tianqi , Li Binbin , Zhang Shiqiang , Zhang Tianzhi , Liu Peng , Wang Qiang , Qian Zhi Rong , Zhu Chengming , Wu Meiying , Zhao Jing 
Published: January 2022

Abstract
Background: Ovarian cancer is the most lethal gynecological cancer which is characterized by extensive peritoneal implantation metastasis and malignant ascites. Despite advances in diagnosis and treatment in recent years, the five-year survival rate is only 25 - 30%. Therefore, developing multifunctional nanomedicine with abilities of promoting apoptosis and inhibiting migration on tumor cells would be a promising strategy to improve the antitumor effect.Methods and results: In this study, we developed a novel ACaT nanomedicine composed of alendronate, calcium ions and cyclin-dependent kinase 7 (CDK7) inhibitor THZ1. With the average size of 164 nm and zeta potential of 12.4 mV, the spherical ACaT nanoparticles were selectively internalized by tumor cells and effectively accumulated in the tumor site. Results of RNA-sequencing and in vitro experiments showed that ACaT promoted tumor cell apoptosis and inhibited tumor cell migration by arresting the cell cycle, increasing ROS and affecting calcium homeostasis. Weekly intraperitoneally administered of ACaT for 8 cycles significantly inhibited the growth of tumor and prolonged the survival of intraperitoneal xenograft mice.Conclusion: In summary, this study presents a new self-assembly nanomedicine with favorable tumor targeting, antitumor activity and good biocompatibility, providing a novel therapeutic strategy for advanced ovarian cancer.
Effects of a Verbal Intervention for Head and Neck Posture on Lumbar Lordosis Angles in Healthy Young and Older Adults: a Preliminary Study
Authors: Zhai Meiling , Huang Yongchao , Zhou Shi , Feng Jiayun , Pei Chaolei , Wen Li 
Published: January 2022

Abstract
Background Postural rehabilitation plays an important role in the treatment of non-specific low back pain. Although pelvic inclination has been widely used to improve lumbar lordosis, the effect of cervical anterior inclination on lumbar lordosis in young and older adults, in sitting and standing posture is still unclear. This preliminary study was designed to examine the influence of changing the cervical anterior angle on the lumbar lordosis angle, through alterations of the head position under the natural sitting and standing conditions, aiming to provide a basis for establishing a new postural rehabilitation strategy.Methods Thirty-eight older (68.4 ± 5.9 years old) and 36 young (24.0 ± 2.2 years old) healthy adults participated in this study. The four spinal regional angles - cervical anterior angle, thoracic kyphosis angle, lumbar lordosis angle, and pelvic foreword inclination angle were measured in standing and relaxed sitting postures to determine the effects of a postural cueing, “inclining head backward and performing chin tuck”, for the head and neck posture on lumbar lordosis angle.Results In the standing posture, the pelvic foreword inclination angle in the older group was significantly smaller (P <0.001) than that in the young group, and increased significantly (P <0.001) post the postural cueing. In addition, the thoracic kyphosis angle in the standing (P = 0.001) and sitting (P = 0.003) positions was significantly reduced post the postural cueing. However, the lumbar lordosis angle post postural cueing increased significantly in both the standing position (P <0.001) and sitting position (P <0.001).Conclusion The results suggest that increasing the cervical anterior angle can indeed increase the lumbar lordosis angle, and the cervical anterior inclination can be used as an alternative to pelvic foreward inclination to improve the lumbar lordosis angle. Furthermore, the change of head and neck posture can reduce the thoracic kyphosis angle, making it possible to establish a new non-invasive body posture rehabilitation strategy.(approval number TJUS2019032)
The Role of the Double Layer for the Pseudocapacitance of the Hydrogen Adsorption on Platinum
Authors: Schalenbach Maximilian , Durmus Y. Emre , Tempel Hermann , Kungl Hans , Eichel Rüdiger-A. 
Published: January 2022

Abstract
Pseudocapacitances such as the hydrogen adsorption on platinum (HAoPt) are associated with faradaic chemical processes that appear as capacitive in their potentiodynamic response, which was reported to result from the kinetics of adsorption processes. This study discusses an alternative interpretation of the partly capacitive response of the HAoPt that is based on the proton transport of ad- or desorbed hydrogen in the double layer. Potentiodynamic perturbations of equilibrated surface states of the HAoPt lead to typical double layer responses with the characteristic resistive-capacitive relaxations that overshadow the fast adsorption kinetics. A potential-dependent double layer representation by a dynamic transmission line model incorporates the HAoPt in terms of capacitive contributions and can computationally reconstruct the charge exchanged in full range cyclic voltammetry data. The coupling of charge transfer with double layer dynamics displays a novel physicochemical theory to explain the phenomenon of pseudocapacitance and the mechanisms in thereon based supercapacitors.
Resting Behavior of Malaria Vectors in Ghana and Its Implication on Vector Control.
Authors: Forson Akua Obeng , Hinne Isaac A. , Dhikrullahi Shittu B. , Sr Isaac Kwame , Mohammed Abdul Rahim , Attah Simon K. , Afrane Yaw A 
Published: January 2022

Abstract
Background: In Sub-Saharan Africa, there is widespread use of long-lasting insecticidal nets (LLINs) and Indoor residual spraying (IRS) to help control the density of malaria vectors and decrease the incidence of malaria in communities. An understanding of the interactions between increased insecticide use and resting behaviour patterns of malaria mosquitoes is important for an effective vector control programme. This study was carried out to investigate the resting behavior, host preference and infection with Plasmodium falciparum of malaria vectors in Ghana in the context of increasing insecticide resistance in malaria vectors in sub-saharan Africa.Methods: Indoor and outdoor resting Anopheline mosquitoes were sampled during the dry and rainy seasons in five sites that were in 3 ecological landscapes [Sahel savannah (Kpalsogou, Pagaza, Libga), Coastal savannah (Anyakpor) and Forest (Konongo) zones] using pyrethrum spray catches (PSC), mechanical aspiration (Prokopack) for indoor collections, pit shelter and Prokopack for outdoor collections. PCR based molecular diagnostics were used to determine mosquito speciation, genotype for knockdown resistance mutations (L1014S and L1014F), G119S Ace-1 mutation, specific host blood meal origins and sporozoite infection in field collected mosquitoes.Results: Anopheles gambiae s. l. was the predominant species (89.95%, n = 1,718), followed by An. rufipes (8.48%, n=162), and An. funestus s. l. (1.57%, n = 30). Sibling species of the Anopheles gambiae revealed An. coluzzii accounted for 63% (95% CI: 57.10 – 68.91), followed by An. gambiae s. s [27% (95% CI: 21.66 – 32.55)], and An. arabiensis [9% (95% CI: 6.22 – 13.57)]. The mean resting density of An. gambiae s. l. was higher outdoors (79.63%; 1,368/1,718) than indoors (20.37%; 350/1,718) (z = -4.815, p< 0.0001). The kdr west L1014F and the Ace-1 mutations were highest in indoor resting An. coluzzii and An. gambiae in the sahel-savannah sites compared to the forest and coastal savannah sites. Overall, the blood meal analyses revealed a large proportion of the malaria vectors preferred feeding on humans (70.2 %) than animals (29.8%) in all sites. The sporozoite rates was only detected in indoor resting An. coluzzii from the sahel savannah (5.0%) and forest (2.5%) zones.Conclusion: The study reports high outdoor resting densities of An. gambiae and An. coluzzii with high kdr west mutation frequencies, and persistence of malaria transmission indoors despite the use of LLINs and IRS. Continuous monitoring of changes in resting behavior of mosquitoes and implementation of complementary malaria control interventions are needed to target outdoor resting Anopheles mosquitoes in Ghana.
Ultrahigh ON/Off Current Ratio γ-Graphyne-1 Nanotube Based Sub 10 nm TFET Modeling and Simulation
Authors: Rouzkhash Behrouz , Salehi Alireza , Ahmadi Mohammad Taghi 
Published: January 2022

Abstract
Utilizing γ-graphyne-1 nanotubes (GyNTs) in the Tunneling Field Effect Transistors (TFETs) suppresses ambipolarity and enhances subthreshold swing (SS) of TFETs which is because of large energy band gap and high electron effective mass of GyNTs. In this research analysis of structural, electronic and thermoelectric properties of γ-graphyne-1 family under the deformation potential (DP) approach reveals that electron-phonon mean free path (MFP) of an Armchair GyNT (3AGyNT) and Zigzag GyNT (2ZGyNT) are 45 and 290 nm, respectively. Therefore, ballistic transport of sub 10 nm 3AGyNT-TFETs and 2ZGyNT-TFETs in different channel lengths are investigated utilizing Non-Equilibrium Green’s Function (NEGF) formalism in the DFTB platform. Ultrahigh Current Ratio (OOCR) value of 1.6 x 1010 at VDD = 0.2 V and very low point SS of 5 mV/dec are belonged to the 3AGyNT-TFET with channel length of 9.6 nm. 2ZGyNT-TFETs shows higher on-state current and SS as well as lower OOCR than those of 3AGyNT-TFETs. A linear relationship between channel length and logarithmic off-state current is reported that is consistent with WKB approximation. The obtained results along with the ultralow power consumption of the suggested GyNT-TFETs, make them as replacement of digital silicon MOSFETs in the next generation nanoelectronic devices.
Development of SSR Markers and Genetic Diversity Evaluation of Mycocentrospora Acerina Causing Round Spot of Panax Notoginseng in Yunan Province, China
Authors: Wang Huiling , Yang Kuan , Guo Liwei , Luo Lifen , He Chi , Li Xiang , Liu Yixiang , Huang Huichuan , Yang Min , Zhu Shusheng , Zhu Youyong , He Xiahong 
Published: January 2022

Abstract

Sanqi round spot, which is caused by Mycocentrospora acerina, is a destructive disease limits the production of Panax notoginseng in Yunnan province of China. However, the disease has not been studied comprehensively. In the current study, we identify M. acerina polymorphic microsatellite markers using CERVUS 3.0 and compare the genetic diversity of its isolates from P. notoginseng round spot using Simple Sequence Repeat (SSR) markers and polyacrylamide gel electrophoresis. Thirty-two SSR markers with good polymorphism were developed using MISA and CERVUS 3.0. The genetic diversity of 187 M. acerina isolates were evaluated using 14 representative SSR primers, and the polymorphic information content values of 14 sites ranged from 0.813 to 0.946, with a total of 264 alleles detected at 14 microsatellite loci. The average expected heterozygosity was 0.8967. The genetic diversity of M. acerina in Yunnan province does not reflect geographic specificity.
Color Image Encryption Scheme Based On Alternate Quantum Walk and Controlled Rubik’s Cube
Authors: Zhao Jingbo , Zhang Tian , Jiang Jianwei , Fang Tong , Ma Hongyang 
Published: January 2022

Abstract
Aiming at solving the trouble that digital image information is easily intercepted and tampered during transmission, we proposed a color image encryption scheme based on alternate quantum random walk and controlled Rubik’s Cube transformation. At the first, the color image is separated into three channels: channel R, channel G and channel B. Besides, a random sequence is generated by alternate quantum walk. Then the six faces of the Rubik’s Cube are decomposed and arranged in a specific order on a two-dimensional plane, and each pixel of the image is randomly mapped to the Rubik’s Cube. The whirling of the Rubik’s Cube is controlled by a random sequence to realize image scrambling and encryption. The scrambled image acquired by Rubik’s Cube whirling and the random sequence received by alternate quantum walk are bitwise-XORed to obtain a single-channel encrypted image. Finally the three-channel image is merged to acquire the final encrypted image. The decryption procedure is the reverse procedure of the encryption procedure. The key space of this scheme is theoretically infinite. After simulation experiments, the information entropy after encryption reaches 7.999, the NPCR is 99.5978%, and the UACI is 33.4317%. The encryption scheme with high robustness and security has a excellent encryption effect which is effective to resist statistical attacks, force attacks, and other differential attacks.
Molecular Mechanism of Ethanol Fermentation Inhibition via Protein Tyrosine Nitration of Pyruvate Decarboxylase by Reactive Nitrogen Species in Yeast
Authors: Eknikom Supapid , Nasuno Ryo , Takagi Hiroshi 
Published: January 2022

Abstract
Protein tyrosine nitration (PTN), in which tyrosine (Tyr) residues on proteins are converted into 3-nitrotyrosine (NT), is one of the post-translational modifications mediated by reactive nitrogen species (RNS). Many recent studies have reported that PTN contributed to signaling systems by altering the structures and/or functions of proteins. This study aimed to investigate connections between PTN and the inhibitory effect of nitrite-derived RNS on fermentation ability using the yeast Saccharomyces cerevisiae. The results indicated that RNS inhibited the ethanol production of yeast cells with increased intracellular pyruvate content. We also found that RNS decreased the activities of pyruvate decarboxylase (PDC) as a critical enzyme involved in ethanol production. Our proteomic analysis revealed that the main PDC isozyme Pdc1 underwent the PTN modification at Tyr38, Tyr157, and Tyr344. The biochemical analysis using the recombinant purified Pdc1 enzyme indicated that PTN at Tyr157 or Tyr344 significantly reduced the Pdc1 activity. Interestingly, the substitution of Tyr157 or Tyr344 to phenylalanine, which is no longer converted into NT, recovered the ethanol production under the RNS treatment conditions. These findings suggest that nitrite impairs the fermentation ability of yeast by inhibiting the Pdc1 activity via its PTN modification at Tyr157 and Tyr344 of Pdc1.
Papaver Decaisnei: GC-MS Alkaloids Profiling, in Vitro Antioxidant, and Anticancer Activity
Authors: Aj.Jabbar Ahmed , Abdullah Fuad Othman , Abdulrahman Kamaran Kaiani , Galali yaseen , Sardar Abdullah Sh. 
Published: January 2022

Abstract
The Papaver L. plant have been well known as a source of pharmaceutically valuable alkaloids (noscapine, thebaine, codeine, roemerine, papaverine and morphine). The current study investigates the phytochemical, in-vitro antioxidant, and anticancer activities of papaver decaisnei, an endemic plant species to the flora of Kurdistan-Iraq. The chemical analysis of the methanolic (MeOH) extracts of flowers, leaves, and roots of papaver decaisnei were made by using gas chromatography-mass spectrophotometry (GC-MS), and the antioxidant activity evaluation done by radical scavenging [on 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2j-azino-bis (3- ethylbenzothiazoline-6-sulfonic acid) (ABTS)], and reducing power [cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP)] assays. The anticancer actions were presented as IC50 (inhibitory concentration at 50%) on human colorectal adenocarcinoma (Caco-2), mammary cancer cells (MCF-7), and human cervical carcinoma (HeLa) cells. The results of the phytochemical analysis showed 17, 19, and 22 chemical compounds for flowers, leaves, and roots of P. decaisnei, respectively. The prevalent organic compounds of P. decaisnei were alkaloids, phenolics, fatty acids, esters, and phytosterols, namely Roemerine (70.44%), Decarbomethoxytabersonine, 9,12,15-Octadecatrien-1-ol, Hexadecanoic acid, 6,8-Dioxa-3-thiabicyclo(3,2,1)octane 3,3-dioxide, and γ-Sitosterol. The antioxidant activity of plant organ extracts was within 39.1-143.5 μg/ml for DPPH and 123.12-276.4 μg/ml for ABTS assays, while, the FRAP and CUPRAC values ranged within 12.4- 34.3 and 42.6-75.8 μg/ml, respectively. The anticancer action of P.decaisnei organ extracts was found against all tested human cell lines (Caco-2, MCF-7, HeLa) with inhibitory concentrations (IC50) values between 125.3-388.4 μg/ml. The presented data on alkaloid contents and biological activity of P. decaisnei can serve a ground knowledge for the future biomedical synthesis and cancer research projects.
Effect of Cultivars and Temperature on Synergistic Interaction Between Panicum Mosaic Virus and Satellite Panicum Mosaic Virus in Switchgrass
Authors: Muhle Anthony , Palmer Nathan , Edme Serge , Sarath Gautam , Yuen Gary , Mitchell Robert , Tatineni Satyanarayana 
Published: January 2022

Abstract
Panicum mosaic virus (PMV), the type species of the genus Panicovirus in the family Tombusviridae, naturally infects switchgrass (Panicum virgatum L.). PMV and its molecular partner, satellite panicum mosaic virus (SPMV), interact synergistically in co-infected millets with exacerbated disease phenotype and increased accumulation of PMV, compared to plants infected only by PMV. In this study, we examined the reaction of switchgrass cvs. Summer and Kanlow to PMV and PMV+SPMV infections at 24°C and 32°C. Switchgrass cv. Summer was susceptible to PMV at both temperatures. In contrast, cv. Kanlow was tolerant to PMV at 24°C but not at 32°C, suggesting that Kanlow harbors temperature-sensitive resistance against PMV. At 24°C, PMV was readily detected in inoculated leaves but not in upper non-inoculated leaves of Kanlow, suggesting that resistance to PMV was likely mediated by abrogation of long-distance virus transport. Co-infection by PMV and SPMV at 24°C and 32°C in cv. Summer but not in Kanlow caused increased symptomatic systemic infection and mild disease synergism with slightly increased PMV accumulation compared to plants infected only by PMV. These data suggest that the interaction between PMV and SPMV in switchgrass is cultivar dependent, manifested in Summer but not in Kanlow. However, co-inoculation of cv. Kanlow by PMV+SPMV caused an enhanced asymptomatic infection, suggesting a role for SPMV in enhancing symptomless infection in a tolerant cultivar. These data suggest that enhanced asymptomatic infections in virus-tolerant switchgrass cultivar could serve as a source for virus spread and play an important role in panicum mosaic disease epidemiology under field conditions. Our data revealed that cultivars, co-infection with SPMV, and temperature influenced the severity of symptoms elicited by PMV in switchgrass.
Inhibition of RANKL and Sema4d Improves Residual Ridge Resorption in Mice.
Authors: Hisamoto Meri , Kimura Shunsuke , Iwata Kai , Iwanaga Toshihiko , Yokoyama Atsuro 
Published: January 2022

Abstract
Residual ridge resorption (RRR) is a chronic and progressive bone resorption following tooth loss. It causes deterioration of the oral environments and leads to the pathogenesis of various systemic diseases. However, the molecular mechanisms and risk factors for RRR progression are still unclear and controversial. In this study, we developed a tooth extraction model using mice for analyzing long-term morphological and gene expression changes in the alveolar bone. We further applied ovariectomy to this model to elucidate the effects of osteoporosis on RRR progression. As a result, the alveolar bone loss was biphasic and consisted of rapid loss in the early stages and subsequently slow and sustained bone loss over a long period. Gene expression analysis indicated that ovariectomy increased the expression of pro-inflammatory cytokines in the alveolar bone and prolonged the activation of osteoclasts same as histological analysis. Furthermore, the expressions of Tnfsf11 and Sema4d kept increasing for a long time in OVX mice. Administration of neutralization antibodies for receptor activator of NF-κB ligand (RANKL) effectively suppressed RRR. Similarly, inhibition of Semaphorin 4d (Sema4d) also improved alveolar bone loss. This study demonstrated that osteoporosis is a risk factor for RRR and that RANKL and Sema4d suppression are potential treatments.