bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of virtual psychological counseling programs during the (COVID-19) pandemic
Authors: Aldhmour Kamal , Almasarweh Sulaiman , Abdelaty Sabrin Abdelaty Labib Abdelaty , Younis Nashwa A. , Al-Qaralleh Osaima Sabri , EL-Bashabsheh Rana Ibrahim 
Published: May 2022

This study aims to identify the effectiveness of a virtual psychological counseling program to activate psychological immunity during the Coronavirus pandemic among students of Mutah University in Jordan. The program was implemented during the second semester of 2019-2020 on a sample of 30 students over 6 weeks period. The results indicated a presence of statistically significant differences between the mean scores of the experimental and control groups on the psychological immunity scale after applying the virtual psychological counseling program in favor of the experimental group and between the mean scores of the experimental group before and after the implementation of the counseling program in favor of the post-measurement, the results showed that the members of the experimental group retained the effect after the follow-up measurement after 30 days from the end of the program of the psychological immunity program.

Keywords: Virtual Counseling Program; Psychological immunity and Coronavirus pandemic.
Inclusive MOOC – educational content for deaf people, a Portuguese proof of concept
Authors: Escudeiro Paula , Galasso Bruno , Teixeira Dirceu , Gouveia Márcia Campos , Escudeiro Nuno 
Published: May 2022

The communication gap between deaf and non-deaf communities arises due to the use of distinct mother languages. A deaf student, who used to communicate in sign language, cannot read fluently materials written in spoken language. This fact causes serious difficulties to deaf students since most didactic materials in higher education are available exclusively in spoken languages. In this paper, we propose a pedagogical model to deliver educational materials in sign language aiming to provide deaf students the same conditions to succeed as the others, i.e., didactical materials available in one’s mother language. Our approach involves the integration of automatic translation technology between spoken and sign language pairs into MOOCs. As a proof of concept, we used this methodology to design a course addressing digital literacy for schoolteachers. The evaluation of the inclusive MOOC and its underlying model reveals its potential, even though further improvements are required, especially regarding evaluation and usability features.

Keywords: educational content; inclusive MOOC, pedagogical model; assistive technology; automatic translator.
Modified Method of Characteristics for Generating Enhanced Oil Recovery Curves
Authors: Agger Christian , Sorensen Henrik 
Published: May 2022

Summary
Gas injection is a frequently used technique for enhanced oil recovery. If the gas injection is carried out at a pressure at or above the minimum miscibility pressure (MMP), it is possible to achieve a recovery that approaches 100%. However, it is not always possible to inject the gas at such a high pressure, which makes it interesting to also know what recoveries can be obtained at pressures below the MMP. The recovery as a function of pressure can be found experimentally by conducting a slimtube experiment or by simulating such an experiment.
Jessen et al. (2001) has, as an alternative to a traditional 1D or cell-to-cell slimtube simulation techniques, proposed a very fast simulation method based on the method of characteristics (MoC). It constructs the composition zones developing in a slimtube during gas injection as well as providing gas and oil saturation profiles and compositions throughout the slimtube. From this information, the recovery can readily be calculated.
The method in Jessen et al.(2001) relies on volumetric gas and oil saturations evaluated at the tie-line intersections which are molar-based. Molar vapor fractions at the tie-line intersections will be below 0 or above 1 and will therefore represent a fluid located outside the two-phase region. With negative molar fractions, the total volume may become negative or zero. When the total volume becomes zero, the volumetric saturations (volume fractions of each phase) cannot be calculated from the molar phase fractions due to zero-division, and the saturation profile calculation cannot be performed.
This paper presents a modified MoC that does not have this weakness and will not encounter a zero-division caused by zero total volume. The paper further presents a scaling method that will ensure that the modified method gives results close to those obtained with the method in Jessen et al. (2001) when the latter does not stop due to a zero-division. The result is a fast, safe, and reliable method for calculating the recovery from an oil field with gas injection conducted at a pressure between the reservoir fluid saturation pressure and the MMP.
Adaptive Multiexpert Learning for Lithology Recognition
Authors: Jiang Jun , Luo Fang , Zhang Hongbao , Yang Shunhui , Zhang Yujie 
Published: May 2022

Summary
Lithology recognition based on well logging plays an important role in drilling optimization and minimizing investment costs. Many existing lithology recognition methods resolve this problem by assuming that they have a balanced lithology data set (i.e., the different classes of lithology data samples have an even distribution). However, this assumption is usually not feasible in the real world, where the data sample size varies enormously between different categories of lithology and thereby leads to significantly degrading recognition performance. To address this problem, we propose adaptive multiexpert learning (AMEL) in this paper. Reweighting methods can be used to solve imbalanced distributions. However, blindly increasing the loss weights of the minority class does not create a balanced model. However, AMEL incorporates reweighting into knowledge distillation (KD) to further optimize the learning process. Our process involves dividing the training set into several groups and training various expert models. Then, we trained student models using a combination of weighted instance losses and distillation losses. Furthermore, we carried out extensive experiments on real-life log data to prove the efficiency of AMEL.
Does stereotactic body radiation therapy with image guidance technology improve treatment outcomes in intra-pulmonary metastasis patients? A randomized controlled study
Authors: Zhang Xiaofang , Song Yingqiu , Wang Chenyu , Zhao Peng , Huang Bo , He Lei , Wang Tianlu 
Published: May 2022

Abstract
BackgroundStereotactic body radiation therapy (SBRT) with image guidance technology aims to improve treatment outcomes in cancer patients. Image guidance radiotherapy (IGRT) is used with SBRT to deliver tumor ablation therapy in 3–5 fractions. This precise radiotherapy delivery method can be applied to various tumor types, and preliminary evidence suggests that it is efficient, accurate, and cost-effective. We present the protocol for a trial aimed at assessing the safety and efficacy profile of SBRT with image guidance technology for the first time. In so doing, the trial seeks to compare the outcomes of patients treated with this method with those of patients treated with conventional fractionated radiotherapy (CFRT). MethodsThis will be a randomized, controlled, prospective study with 102 lung cancer patients undergoing palliative treatment for intra-pulmonary metastasis. The trial will be based at the Liaoning Cancer Hospital Medical Center (a tertiary medical center). Using the random number table method, a random number sequence is generated, and the 102 patients are randomized (1:1) to the experiment group (SBRT with IGRT group) or the control group (CFRT group). The primary outcome is progression-free survival. The secondary outcomes include tumor response measures, overall survival, quality of life scores, and Acute and chronic adverse reactions, recorded over a 2-year follow-up period. After the final patient completes the follow-up study, Statistical Product and Service Solutions (SPSS) software is used for scientific and rigorous data analysis. This is version 1.0 of protocol on October 31, 2020. The recruitment process for this clinical trial commenced on February 1, 2021, and will end on January 31, 2023. DiscussionThe study will provide high-quality clinical evidence to support the efficacy and safety of IGRT/SBRT versus CFRT in the treatment of patients with intrapulmonary metastases from lung cancer and has not yet been reported. Trial registrationThis trial is registered with the Chinese Clinical Trial Registry (ChiCTR1900027548) (17 November, 2019). (URL: https://www.docin.com/p-917667939.html)
Effect of Intraoperative Goal-directed Fluid Therapy on the Postoperative Brain Edema in Patients undergoing High-Grade Gliomas Resections: a study protocol of randomized control trial
Authors: Liu Xiaoyuan , Zhang Xingyue , Fan Yifang , Li Shu , Peng Yuming 
Published: May 2022

Abstract
Introduction Brain edema is the most frequent postoperative complication after brain tumor resection, especially in patients with high-grade glioma. However, the effect of SVV-based goal-directed fluid therapy (GDFT) on postoperative brain edema and the prognosis remain unclear. Methods and analysis This is a prospective, randomized, double-blinded, parallel-controlled trial aiming to observe whether stroke volume variation (SVV)-based GDFT could improve the postoperative brain edema in patients undergoing supratentorial high-grade gliomas compared with traditional fluid therapy. The patient will be given 3mL/kg hydroxyethyl starch solution when the SVV is greater than 15% continously for more than 5 minutes intraoperatively. The primary outcome will be postoperative cerebral edema volume on brain CT within 24 hours. Ethics and dissemination This trial has been registered at ClinicalTrial.gov (NCT03323580) and approved by the Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (reference number: KY2017-067-02). The findings will be disseminated in peer-reviewed journals and presented at national or international conferences relevant to subject fields. Trial registration number NCT03323580.
Predictors of Viral Load Test Result over Time among HIV Adult Patients on Highly Active Antiretroviral Therapy (HAART): A Retrospective Study in Zewditu Memorial Hospital, Ethiopia
Authors: Agegn Ayitenew , Abebe Mengistu , Belay Kidist 
Published: May 2022

Abstract
Background: HIV attacks the CD4 cell which is responsible for the body's immune response to infectious agents. The main objective of this study was to identify Predictors of Viral Load Result over time among HIV Patients Initiated HAART in Zewditu Memorial Hospital. Methods: A retrospective cohort study design was conducted on 161 HIV infected patients under HAART whose follow-ups were from January 2014 up to December 2017. Generalized linear mixed-effects model (Binary logistic regression model) for status of viral load result was used for inferential data analysis. The Hosmer and Lemeshow Goodness of fit Test and the likelihood ratio tests were used for measures of goodness of fit for categorical dataResults: The descriptive statistics revealed that the longitudinal response variable which was viral load status among HIV patient’s, in the study 90 of the patients were detected at baseline and 71 of them were not detected at baseline measurements. The estimated odds of the detected patients who lived in rural area was found to be about 6.3 (AOR= 6.30) times that of the odds of detected patients in urban area controlling for the other variables in the model. The estimated odds of the detected disclosed patients was found to be about 80.5% (AOR=0.195) less likely than the odds of detected not disclosed Patients by controlling for the other variables in the model.Conclusions: The predictor variables; observation time, weight, residence, age, educational level, clinical stage, functional status, baseline CD4 cell count and disclosure were statistically and significantly associated with status of viral load. The proportional odds model assumption was also checked numerically using Hosmer and Lemeshow goodness-of-fit statistics. The results justified that the assumption was fulfilled.
Dosimetric evaluation of a spinal cord dose-limiting 3D-CRT technique for radiotherapy of spinal metastases
Authors: Arnold Christian Cornelius , Toussaint André , Mantel Frederick , Flentje Michael , Bratengeier Klaus 
Published: May 2022

Abstract
Background: To evaluate the possible advantages of a simple spinal cord (SC) dose-limiting three-dimensional conformal radiotherapy (3D-CRT) technique in comparison to conventional two-dimensional (2D) techniques and other 3D-CRT techniques for spinal bone irradiation.Methods: For 41 spinal target volumes, seven different techniques were evaluated, using a standard schedule of 30 Gy in 10 fractions. The SC dose-limiting 3D-CRT technique 1F2S-18MV using a single posterior field (F) supplemented by two anterior segment fields (S) and 18MV photon beams was compared to two conventional 2D techniques (a single posterior field, PA and two opposed anterior-posterior fields, APPA), three other 3D-CRT techniques (a single posterior field supplemented by four segment fields, 1F4S; two wedged fields, WD and the SC dose-limiting variant using 6MV, 1F2S-6MV) plus the original clinically applied plans. For comparison, parameters of the dose homogeneity in the target volume as well as the dose exposure of the SC and other organs at risk (OARs) were assessed.Results: 1F2S-18MV demonstrated notably better results for all target volume parameters compared to the conventional 2D techniques (p<0.001). Limitation of the SC dose was significantly superior with 1F2S-18MV in comparison to PA and APPA (SC Dmean: 28.9±0.4 Gy vs. 30.1±0.6 Gy and 30.1±0.4 Gy; SC Dmax: 30.9±0.7 Gy vs. 32.5±1.0 Gy and 31.8±0.7 Gy; SC D1cm³: 30.1±0.6 Gy vs. 31.7±0.9 Gy and 31.1±0.6 Gy; p<0.001). Likewise, lower mean SC doses with 1F2S-18MV were observed in comparison to the more treatment time-consuming 3D-CRT techniques (1F4S, WD) and the original plans without relevant compromises on the dose homogeneity in the target volume and the dose exposure to the other OARs. 1F2S-18MV showed overall better results than 1F2S-6MV.Conclusions: In treatment planning of spinal metastases, simple variants of 3D-CRT-techniques like 1F2S-18MV can offer a significant dose limitation to the SC while providing a sufficient dose coverage of the target volume. Especially patients with favorable life expectancy and potential need for re-irradiation might benefit from such 3D-CRT approaches.
Monocyte Distribution Width as a Pragmatic Diagnostic Screen for SARS-CoV-2 and Influenza Infection
Authors: Badaki-Makun Oluwakemi , Levin Scott , Debraine Arnaud , Hernried Benjamin , Malinovska Alexandra , Smith Aria , Toerper Matthew , Fenstermacher Katherine Z.J. , Cottle Taylor , Latallo Malgorzata , Rothman Richard E. , Hinson Jeremiah S. 
Published: May 2022

Abstract
Background
Monocyte distribution width (MDW) is a novel marker of monocyte activation, which is known to occur in the immune response to viral pathogens. Our objective was to determine the diagnostic performance of MDW and other leukocyte parameters for SARS-CoV-2 and influenza infection.
Methods
This was a prospective cohort analysis of adult patients who underwent complete blood count (CBC) and SARS-CoV-2 or influenza testing in an Emergency Department (ED) between January 2020 and July 2021. The primary outcome was SARS-CoV-2 or influenza infection. Secondary outcomes were measures of severity of illness including inpatient hospitalization, critical care admission, hospital lengths of stay and mortality. Descriptive statistics and diagnostic performance measures were evaluated for monocyte percentage, MDW, white blood cell (WBC) count, and neutrophil to lymphocyte ratio (NLR).
Results
3,425 ED patient visits were included. SARS-CoV-2 testing was performed during 1,923 visits with a positivity rate of 5.4%; influenza testing was performed during 2,090 with a positivity rate of 2.3%. MDW was elevated in patients with SARS-Cov-2 (median 23.0U; IQR 20.5–25.1) or influenza (median 24.1U; IQR 22.0-26.9) infection, as compared to those without (18.9U; IQR 17.4–20.7 and 19.1U; 17.4–21, respectively, p < 0.001). Monocyte percentage, WBC and NLR values were within normal range in patients testing positive for either virus. MDW identified SARS-CoV-2 and influenza positive patients with an area under the curve (AUC) of 0.83 (95% CI 0.79–0.86) and 0.83 (95% CI 0.77–0.88), respectively. At the accepted cut-off value of 20U for MDW, sensitivities were 83.7% (95% CI 76.5–90.8%) for SARS-CoV-2 and 89.6% (95% CI 80.9–98.2%) for influenza, compared to sensitivities below 45% for monocyte percentage, WBC and NLR. MDW negative predictive values were 98.6% (95% CI 98.0-99.3%) and 99.6% (95% CI 99.3–100.0%) respectively for SARS-CoV-2 and influenza.
Conclusions
Monocyte Distribution Width (MDW), available on a routine complete blood count (CBC) with differential, is sensitive and specific for the early detection of SARS-CoV-2 and influenza infection.
Usefulness of Trabecular Bone Score (TBS) to Identify Bone Quality and Bone Fragility in Primary Hyperparathyroidism compared with Secondary Hyperparathyroidism——hypercortisolism patients
Authors: Tang Wangna , Jia Hongwei , Wang Baoping , Chai Yun , Liu Tong , Wang Hao , Dai Chenlin 
Published: May 2022

Abstract
Purpose: This study was designed to evaluates the effects of TBS, bone mineral density (BMD), and fracture risk in PHPT patients.Methods: The study group comprised 82 PHPT patients, and sex-, age-matched 50 hypercortisolism patients. The BMD and TBS were measured using DXA and TBS iNsight software. A receiver operating curve and logistic analysis were used to evaluate TBS. The FRAX index was calculated with and without the adjustment of TBS to evaluate the sensitivity and specificity of fracture risk. Results: Sixty-two per cent of PHPT patients exhibited degraded bone microstructure, thirty-nine per cent were diagnosed with osteoporosis by DXA. TBS had a moderately positive correlation with the lumbar spine, femoral neck, and total hip BMD. For PHPT patients, the BMD of the fracture group was lower compared to that of the non-fracture group, and the FRAX indexes were higher than that of the non-fracture group. There was no statistical difference in TBS between the fracture group and the non-fracture group. In hypercortisolism patients, there was no statistical difference in BMD and TBS between the fracture group and the non-fracture group. In PHPT patients, TBS was a predictor of osteoporosis even after adjusting for age, gender, and BMI (P = 0.001, OR = 0.120, 95% CI [0.033-0.435]); In contrast, TBS was not a predictor in hypercortisolism patients, regardless of whether adjusting confounding factors or not. The sensitivity of FRAX in the prediction of fracture risk in PHPT and hypercortisolism is higher than TBS alone. Conclusions: TBS combined with BMD can increase the diagnostic accuracy of PHPT patients. Moreover, FRAX is more sensitive to fracture prediction than TBS in patients with PHPT or hypercortisolism.
Feeding back of individual genomic results in Botswana: mapping opportunities and challenges
Authors: Kasule Mary , Matshaba Mogomotsi , Wonkam Ambroise , de Vries Jantina 
Published: May 2022

Abstract
Purpose: We aimed to explore the views of stakeholders in Botswana involved in developing, implementing and applying ethical standards for return of individual study results from genomic research on feeding back individual genomic research results, thus mapping opportunities for and challenges regarding actionability requirements that could determine whether individual genomic research results should be fed back to participants.Methods: Using in-depth interviews, we explored the views of sixteen (16) stakeholders involved in the conduct or regulation of genomic research in Botswana regarding what they thought were the opportunities for and challenges in feeding back individual genomic research results. We also deliberated on questions regarding whether the feedback of findings was necessary or not, whether only genomic results that have been verified in accredited diagnostic laboratories should be fedback and how important it is that participants who receive results have access to the interventions that would mediate the effects of the genomic findings. Coded data was analyzed through an iterative process of analytic induction to document and interpret themes.Results: Overall, respondents were of the view that feedback of actionable individual genomic results was an important outcome that could benefit participants. However, a number of themes surfaced that pointed to opportunities for and challenges that exist in Botswana regarding requirements for feedback of actionable results that were mapped. Some of the opportunities cited by the respondents included the existence of good governance; democracy and humanitarianism; universal healthcare system; national commitment to science; research and innovation to transform Botswana into a knowledge-based economy; and applicable standard of care which could promote actionability. On the other hand, contextual issues like the prerequisite for return of only genomic research results that have been validated in accredited laboratories, the high cost of validation of genomic results, and linkage to care, as well as lack of experts like genomic scientists and counselors were considered as challenges for return of individual results.Conclusion: We propose that decisions whether and which genomic results to return take into consideration contextual opportunities and challenges for actionability for return of results in a research setting. This is likely to avoid or minimize ethical issues of justice, equity and harm regarding actionability decisions.
Plant regeneration from apple (Malus×domestica Borkh.) anther culture-derived embryos
Authors: zhang chunfen , Deng Shu , Cao Qiufen , Komori Sadao , Xiao Rong 
Published: May 2022

Abstract
To improve the adaptation process of the obtained androgenic plants and achieve high acquisition efficiency of plants in anther culture, six cultivars, ‘ASP’, ‘Danxian’, ‘Fuji’, ‘Gala’, ‘SD’, and ‘Senshu’, were used to investigate the effect of sucrose concentration on root formation from embryos in the cold treatment and the effect of plant regulators in the shoot regeneration medium for rooted and nonrooted embryos. The results indicated that cold treatment medium containing 1.5% sucrose showed the highest root formation in the three cultivars ‘ASP’, ‘Senshu’ and ‘SD’. The rooted embryos readily developed into shoots compared to the nonrooted embryos. For rooted embryos, the preferred medium for shoot regeneration was 1/2 MS hormone-free medium containing 1.5% sucrose, whereas the preferred medium for nonrooted embryos was MS or 1/2 MS medium containing BAP and 3% sucrose. The genotype also played an important role in the process of plant regeneration from anther culture-derived embryos in apple. The cultivars ‘ASP’ (14.4%), ‘SD’ (6.2%) and ‘Danxian’ (6.0%) showed the highest rates of embryo induction. The cultivars ‘Danxian’, ‘Gala’, and ‘Senshu’ showed the highest rates of regeneration from embryos to shoots of 33.7%, 26.9% and 21.55%, respectively. Consequently, the total efficiency from anthers to shoots of ‘Danxia’ was 2.33%, followed by ‘Gala’, ‘Fuji’, ‘Senshu’, ‘SD’ and ‘ASP’, which had efficiencies of 0.35%, 0.30%, 0.30%, 0.27% and 0.25%, respectively.