bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine‐learning predictions of caffeine co‐crystal formation accompanying experimental and molecular validations
Authors: Syed Tanweer A. , Ansari Khursheed B. , Banerjee Arghya , Wood David A. , Khan Mohd Shariq , Al Mesfer Mohammed K. 
Published: December 2022

AbstractCaffeine co‐crystal formation with other compounds is investigated in this study using a variety of machine learning (ML) methods. A total of 140 caffeine co‐crystal data points are used to train classification learners using MATLAB ML models. Kernel neural network, ensemble tree‐based, logistic regression, and support vector machine algorithms were among the ML models tested. The logistic regression algorithm produced the most accurate predictions of caffeine‐co‐crystal formation, with a validation accuracy of 97.1%. Experiments and molecular interaction studies between caffeine and other tea compounds (catechin and catechol) are used to validate ML predictions. As part of the evaluation, a random forest classifier was applied to select 1440 known molecular descriptors, among them 30 descriptors identified as responsible for caffeine co‐crystal formation were used for training and validation purpose. The reliability of the trained logistic regression algorithm means that it is suitable for use in predicting possible co‐crystals between caffeine and other compounds, thereby providing an understanding of caffeine co‐crystals formation without recourse to rigorous experimental tests.Practical applicationsCaffeine co‐crystals formation with other tea components is crucial to understand the generation of tea cream, which is undesirable to customers. Using a data‐driven approach (or machine learning) to identify the possible molecular combinations involved in co‐crystal formation can significantly reduce experimental test requirements. Machine learning data can help with investigations aimed at detailed characterization of ready‐to‐drink concentrated tea formulations. Furthermore, this study will assist researchers and policymakers in meeting the Sustainable Development Goals of “Industry, Innovation, and Infrastructure.”
Use of Psychoactive Substances during the Perinatal Period: Guidelines for Interventions during the Perinatal Period from the French National College of Midwives
Authors: Chanal Corinne , Mazurier Evelyne , Doray Bérénice 
Published: December 2022

AbstractBased on their clinical practice and an extensive review of the literature, the authors propose a framework of procedures to be followed to provide services to all women of childbearing age who use psychoactive substances (alcohol, cannabis, cocaine, amphetamines, and opioids), especially during pregnancy or during the postpartum and breastfeeding periods, in view of their individual situations and environmental contexts.
Use of Cosmetic Products in Pregnant and Breastfeeding Women and Young Children: Guidelines for Interventions during the Perinatal Period from the French National College of Midwives
Authors: Marie Cécile , Garlantézec Ronan , Béranger Rémi , Ficheux Anne‐Sophie 
Published: December 2022

AbstractWe conducted a literature review focusing on the use and health effects of cosmetics, especially among pregnant and lactating women and young children. Based on these data, we propose clinical practice guidelines for health care professionals to use for informing and advising their patients. These include the recommendations that families: (1) reduce the number and the frequency of use (grade B) and the amount applied (expert consensus) of all cosmetic products during the perinatal period and among children; (2) prefer simple, fragrance‐free, and rinsable products, with short ingredient lists (expert consensus); and (3) for children, avoid industrial wipes and prefer water, with suitable soap when necessary.
Young Children and Screens: Guidelines for Intervention during the Perinatal Period from the French National College of Midwives
Authors: Bernard Jonathan Y. , Caron François‐Marie , Salinier‐Rolland Catherine 
Published: December 2022

AbstractScreens and digital media are increasingly present in family environments. This article reports the published data about children's screen use in France and elsewhere. We next synthesize the scientific literature on the relations between screen use and child development and then summarize current national and international guidelines about children's screen use before the age of 5 years. Based on these elements, we propose clinical practice guidelines for counseling women during the perinatal period.Précis: Current knowledge on children's screen use and its relationship to their development is summarized including guidelines and suggestions to help parents monitor screen use.
Metabolic reprogramming of Helicoverpa armigera larvae by HearNPV facilitates viral replication and host immune suppression
Authors: Tian Zhiqiang , Zhu Lin , Michaud J. P. , Zha Meng , Cheng Jie , Shen Zhongjian , Liu Xiaoming , Liu Xiaoxia 
Published: December 2022

AbstractBaculoviruses are highly evolved parasites that genetically reprogram the developing phenotype of their host insect to produce a vessel for virus replication and dispersal. Here we show that larvae of Helicoverpa armigera infected with HearNPV accumulate glucose in the midgut, which reduces food consumption and alters the dynamics of pathways governing metabolism and immunity. We used transcriptomics to demonstrate the role of the insulin signalling pathway in regulating the HearNPV infection process. Dietary restriction decreased mortality of infected larvae and reduced viral replication prior to death, whereas dietary supplementation with glucose produced the opposite effects. The expression of most tricarboxylic acid cycle (TCA) and energy metabolism‐related genes was reduced in infected larvae, whereas the expression of immunity‐, glycolysis‐ and insulin‐related genes was enhanced. Treatment of infected larvae with insulin increased their survival, reduced viral replication and inhibited climbing behaviour compared to a control treatment with DMSO, whereas RNAi suppression of the insulin receptor gene produced the opposite effects. Inhibition of glycolysis with dichloroacetate (DCA) promoted viral replication and accelerated larval death, but inhibition of the TCA cycle with 2‐deoxyglucose (2‐DG) did not, although both diminished climbing behaviour. This work demonstrates that successful baculovirus infections hinge on metabolic reprogramming of the host and concurrent suppression of immune responses in the larval midgut, with the insulin signalling pathway mediating a trade‐off between glucose metabolism and virus resistance.
Recording and analysis of slow waves of the small intestine of mice with heart failure
Authors: Javan‐Khoshkholgh Amir , Sassoon Joseph C. , Behbodikhah Jennifer , Dai Wenchen , Alemu Senayt , Quadri Saad , Singh Mohnish , Savinova Olga V. , Farajidavar Aydin 
Published: December 2022

AbstractBackgroundGastrointestinal (GI) symptoms in heart failure (HF) patients are associated with increased morbidity and mortality. We hypothesized that HF reduces bioelectrical activity underlying peristalsis. In this study, we aimed to establish a method to capture and analyze slow waves (SW) in the small intestine in mice with HF.MethodsWe established a model of HF secondary to coronary artery disease in mice overexpressing tissue‐nonspecific alkaline phosphatase (TNAP) in endothelial cells. The myoelectric activity was recorded from the small intestine in live animals under anesthesia. The low‐ and high‐frequency components of SW were isolated in MATLAB and compared between the control (n = 12) and eTNAP groups (n = 8). C‐kit‐positive interstitial cells of Cajal (ICC) and Pgp9.5‐positive myenteric neurons were detected by immunofluorescence. Myenteric ganglia were assessed by hematoxylin and eosin (H&E) staining.ResultsSW activity was successfully captured in vivo, with both high‐ and low‐frequency components. Low‐frequency component of SW was not different between endothelial TNAP (eTNAP) and control mice (mean[95% CI]: 0.032[0.025–0.039] vs. 0.040[0.028–0.052]). High‐frequency component of SW showed a reduction eTNAP mice relative to controls (0.221[0.140–0.302] vs. 0.394[0.295–0.489], p < 0.01). Dysrhythmia was also apparent upon visual review of signals. The density of ICC and neuronal networks remained the same between the two groups. No significant reduction in the size of myenteric ganglia of eTNAP mice was observed.ConclusionsA method to acquire SW activity from small intestines in vivo and isolate low‐ and high‐frequency components was established. The results indicate that HF might be associated with reduced high‐frequency SW activity.
Spatial neglect encompasses impaired verticality representation after right hemisphere stroke
Authors: Lafitte Rémi , Jeager Marie , Piscicelli Céline , Dai Shenhao , Lemaire Camille , Chrispin Anne , Davoine Patrice , Dupierrix Eve , Pérennou Dominic 
Published: December 2022

AbstractSpatial neglect after right hemisphere stroke (RHS) was recently found to encompass lateropulsion, a deficit in body orientation with respect to gravity caused by altered brain processing of graviception. By analogy, we hypothesized that spatial neglect after RHS might encompass an altered representation of verticality. We also assumed a strong relation between body neglect and impaired postural vertical, both referring to the body. To tackle these issues, we performed contingency and correlation analyses between two domains of spatial neglect (body, extra‐body) and two modalities of verticality perception (postural, visual) in 77 individuals (median age = 67) with a first‐ever subacute RHS (1–3 months). All individuals with a transmodal (postural and visual) tilt in verticality perception (n = 26) had spatial neglect, but the reverse was not found. Correlation and multivariate analyses revealed that spatial neglect (and notably body neglect) was associated more with postural than visual vertical tilts. These findings indicate that after RHS, an impaired verticality representation results from a kind of graviceptive neglect, bearing first on somaesthetic graviception and second on vestibular graviception. They also suggest that the human brain uses not only a mosaic of 2D representations but also 3D maps involving a transmodal representation of verticality.
A new problem for rules
Authors: Kaplan Jeffrey 
Published: December 2022

AbstractThis paper presents a series of arguments aimed at showing that, for an important subclass of social rules—non‐summary rules—no adequate metaphysical account has been given, and it tentatively suggests that no such account can be given. The category of non‐summary rules is an important one, as it includes the rules of etiquette, fashion, chess, basketball, California state law, descriptive English grammar, and so on. This paper begins with behavioristic accounts of the conditions for the existence of such rules, and proceeds through progressively more complex accounts, all the way to what are labeled ‘normative attitude accounts,’ which are prima facie plausible and particularly popular. In each case it is argued that the type of account under consideration cannot explain the existence of the relevant type of social rule.
Between nature and nurture: The genetic overlap between psychological attributes and selection into public service employment
Authors: Tao Lei , Liang Hailun , Wen Bo , Huang Tao 
Published: December 2022

AbstractPublic administration scholars have had a long‐lasting interest in examining individual differences relevant to the attractiveness of public service employment. However, very few studies have explored the genetic underpinnings of these variations. This article builds upon recent behavioral genetics literature and explores whether there are genetic overlaps between psychological attributes and selection into public service employment. We construct the polygenic risk scores (PRSs) on two psychological attributes—neuroticism and positive affect—to model the genetic influence on public service employment in a nationwide UK dataset with 262,795 participants. The results suggest that the PRS of positive affect is a significant predictor of individuals' selection into public service employment, implying that individuals with high innate happiness are more likely to self‐select into service work. Taking the existing socialization literature and this result into consideration, our findings support that both nature and nurture factors shape individuals' selection into public service employment.
Politics of problem definition: Comparing public support of climate change mitigation policies using machine learning
Authors: Choi Junghwa , Wehde Wesley , Maulik Romit 
Published: December 2022

AbstractPublic support is a key contributor to successful policy adoption and implementation. Given the urgency of climate change mitigation, scholars have explored various determinants that affect public support for climate change mitigation policy. However, the relative decisiveness of these factors in shaping public support is insufficiently examined. Therefore, we deploy interpretable machine learning to understand which factors, among many previously investigated, are most decisive for structuring public support for various climate change mitigation policies. In this paper, we particularly look at the decisiveness of problem definition for shaping public support among various factors. Using U.S national survey data, we find that how individuals define the issue of climate change is more decisive for structuring public support for promoting renewable energy and regulating pollutants to mitigate the risks associated with climate change. However, the results also indicate that the most decisive factors associated with public support vary depending on the types of mitigation policy. We conclude that different strategies should be utilized to increase public support for various climate change mitigation policy options. Our findings contribute to a scholarly understanding of the specific politics of problem definition in the context of environmental and climate change policy.
Advanced practice nurse capabilities: A mixed methods systematic review
Authors: Hako Laura , Turunen Hannele , Jokiniemi Krista 
Published: December 2022

AbstractBackgroundGlobal health challenges demand the optimal use of nurses' professional competence and capability. Competencies related to the roles of advanced practice nurses have been developed, but research on these nurses' capabilities remains limited.AimTo summarise and compare the literature on the capabilities of advanced practice nurses and the dimensions of these capabilities.MethodsWe carried out a mixed methods systematic review, using CINAHL, PubMed, and Scopus to search literature published between 1998 and 2021. The quality of the selected articles was evaluated with the JBI Critical Appraisal Tools. We employed abductive content analysis, including deductive and inductive analysis. The reporting was guided by the standards of the Preferred Reporting Items for Systematic Review and Meta‐Analysis Statement.ResultsEleven articles out of 357 met the inclusion criteria. We identified all five dimensions of Hase and Davis's (1999) capability framework: can apply competencies in familiar as well as unfamiliar situations, is creative, has a high degree of self‐efficacy, knows how to learn, and works well in teams. Additionally, we found a new dimension of capability: identifies factors affecting the scope of practice.LimitationsThis mixed methods systematic review was conducted about a little‐studied topic. Because country‐specific differences exist and consensus on advanced practice nursing roles is lacking, the concept of advanced practice nurse capabilities cannot be directly generalised.ConclusionsCapability is a requirement and a necessity in the performance of advanced practice nurses. Identifying and defining the dimensions of advanced practice nurses' capabilities will lead the way in developing the roles, education, and capability assessments of advanced practice nurses. Identification of advanced practice nurses' capability will facilitate role understanding, visibility, and implementation in health care services. This can improve the quality and accessibility of care and improve the cost‐effectiveness of the use of health care professionals.
Examining 7 years of implementing quality management systems in medical laboratories in sub‐Saharan Africa
Authors: Odhiambo Collins O. , van der Puije Beatrice , Maina Michael , Mekonen Teferi , Diallo Samba , Datema Tjeerd , Loembe Marguerite M. , Kebede Yenew , Ndlovu Nqobile , Ondoa Pascale 
Published: December 2022

AbstractBackgroundAchievement of ISO15189 accreditation demonstrates competency of a laboratory to conduct testing. Three programmes were developed to facilitate achievement of accreditation in low‐ and middle‐income countries: Strengthening Laboratory Management Towards Accreditation (SLMTA), Stepwise Laboratory Improvement Process Towards Accreditation (SLIPTA) and Laboratory Quality Stepwise Implementation (LQSI).ObjectiveTo determine the level of accreditation and associated barriers and facilitators among medical laboratories in the WHO‐AFRO region by 2020.MethodsA desk review of SLIPTA and SLMTA databases was conducted to identify ISO15189‐accredited medical laboratories between January 2013 and December 2020. Data on access to the LQSI tool were extracted from the WHO database. Facility and country characteristics were collected for analysis as possible enablers of accreditation. The chi‐square test was used to analyse differences with level of significance set at <0.05.ResultsA total of 668 laboratories achieved accreditation by 2020 representing a 75% increase from the number in 2013. Accredited laboratories were mainly in South Africa (n = 396; 55%) and Kenya (n = 106; 16%), two countries with national accreditation bodies. About 16.9% (n = 113) of the accredited laboratories were registered for the SLIPTA programme and 26.6% (n = 178) for SLMTA. Approximately 58,217 LQSI users were registered by December 2020. Countries with a higher UHC index for access to HIV care and treatment, higher WHO JEE scores for laboratory networks, a larger number of registered LQSI users, with national laboratory policy/strategic plans and PEPFAR‐priority countries were more likely to have an accredited laboratory. Of the 475 laboratories engaged in the SLIPTA programme, 154 attained ≥4 SLIPTA stars (ready to apply for accreditation) and 113 achieved ISO 15189 accreditation, with 96 enrolled into the SLMTA programme. Lower‐tier laboratories were less likely to achieve accreditation than higher‐tier laboratories (7.7% vs. 30%) (p < 0.001). The probability of achieving ISO 15189 accreditation (19%) was highest during the first 24 months after enrolment into the SLIPTA programme.ConclusionTo sustainably anchor quality improvement initiatives at facility level, national approaches including access to a national accreditation authority, adoption of national quality standards and regulatory frameworks are required.
The utility of the ‘Arable Weeds and Management in Europe’ database: Challenges and opportunities of combining weed survey data at a European scale
Authors: Metcalfe Helen , Bürger Jana , Redwitz Christoph von , Cirujeda Alicia , Fogliatto Silvia , Dostatny Denise F. , Gerowitt Bärbel , Glemnitz Michael , González‐Andújar José L. , Hernández Plaza Eva , Izquierdo Jordi , Kolářová Michaela , Ņečajeva Jevgenija , Petit Sandrine , Pinke Gyula , Schumacher Matthias , Ulber Lena , Vidotto Francesco , Fried Guillaume 
Published: December 2022

AbstractOver the last 30 years, many studies have surveyed weed vegetation on arable land. The ‘Arable Weeds and Management in Europe’ (AWME) database is a collection of 36 of these surveys and the associated management data. Here, we review the challenges associated with combining disparate datasets and explore some of the opportunities for future research that present themselves thanks to the AWME database. We present three case studies repeating previously published national scale analyses with data from a larger spatial extent. The case studies, originally done in France, Germany and the UK, explore various aspects of weed ecology (community composition, management and environmental effects and within‐field distributions) and use a range of statistical techniques (canonical correspondence analysis, redundancy analysis and generalised linear mixed models) to demonstrate the utility and versatility of the AWME database. We demonstrate that (i) the standardisation of abundance data to a common measure, before the analysis of the combined dataset, has little impact on the outcome of the analyses, (ii) the increased extent of environmental or management gradients allows for greater confidence in conclusions and (iii) the main conclusions of analyses done at different spatial scales remain consistent. These case studies demonstrate the utility of a Europe‐wide weed survey database, for clarifying or extending results obtained from studies at smaller scales. This Europe‐wide data collection offers many more opportunities for analysis that could not be addressed in smaller datasets; including questions about the effects of climate change, macro‐ecological and biogeographical issues related to weed diversity as well as the dominance or rarity of specific weeds in Europe.
The effectiveness of lifestyle interventions for diabetes remission on patients with type 2 diabetes mellitus: A systematic review and meta‐analysis
Authors: Zhang Yating , Yang Yajie , Huang Qifang , Zhang Qi , Li Mingzi , Wu Yi 
Published: December 2022

AbstractBackgroundConventional wisdom affirmed that diabetes was irreversible, but current research shows that lifestyle interventions may achieve diabetes remission among patients with type 2 diabetes mellitus. Recently, many original studies have examined the effectiveness of lifestyle interventions. However, great heterogeneity in intervention approaches resulted in inconsistent intervention effects.AimsThe aim of this study was to determine the effectiveness of lifestyle interventions for diabetes remission among patients with type 2 diabetes mellitus.MethodsPubMed, CINAHL, Embase, Web of Science Core Collection, and Cochrane Library were searched for relevant articles from their inceptions to March 26, 2021. Reference lists and a relevant journal were searched manually as well. Both randomized controlled trials and quasi‐experimental studies were included. The quantitative data extracted from the selected studies included diabetes remission rate, weight, and quality of life score. The risk of bias was assessed by the Cochrane and Joanna Briggs Institute's tool. RevMan version 5.3. was used to carry out the meta‐analysis.ResultsThis systematic review included 12 studies involving 3997 patients with type 2 diabetes mellitus. Lifestyle interventions included in the studies were mainly divided into diet‐only interventions and diet combined with physical activity interventions. Among them, there were three types of diet: (1) low‐energy diet, (2) low carbohydrate diet, and (3) Mediterranean diet. Moderate‐intensity aerobic and resistance physical activity, walking, and maintaining habitual physical activity were the three types of physical activity interventions employed in the included studies. The results indicated that lifestyle interventions were effective for achieving diabetes remission, reducing weight, and improving quality of life in patients with type 2 diabetes mellitus.Linking Evidence to ActionLifestyle interventions were associated with significant effects on diabetes remission, reducing weight, and improving quality of life. As an important part of lifestyle interventions, diet and physical activity have a significant effect on blood glucose and weight control in patients with type 2 diabetes mellitus. It is therefore suggested that the contents of lifestyle interventions should focus on diet and physical activity.