bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 and communication: A sentiment analysis of US state governors’ official press releases
Authors: Tano Mauricio , Baek Juha , Ordonez Adriana , Bosetti Rita , Menser Terri , Naufal George , Kash Bita 
Published: August 2022

Objectives
This study examines the contents of official communication from United States governors’ offices related to the COVID-19 pandemic to assess patterns in communication and to determine if they correlate with trends for COVID cases and deaths.

Methods
We collected text data for all COVID-19 related press releases between March 1 and December 31, 2020 from the US governors’ office websites in all 50 states. An automated parsing and sentiment analyzer assessed descriptive statistics and trends in tone, including positivity and negativity.

Results
We included a total of 7,720 press releases in this study. We found that both positive and negative sentiments were homogenous across states at the beginning of the pandemic but became heterogeneous as the pandemic evolved. The same trend applied to the frequency and tone of press releases. Sentiments across states were overall positive with a small level of negativity. We observed a reactive official communication to the evolution of the number of COVID-19 cases rather than responsive or preventive.

Conclusions
The findings of both positivity and negativity in press communications suggest that the effect of discounted importance was present in official communications. Our findings support a state-dependent optimal communication frequency and tone, agreeing with the curvilinear communication model of organizational theory and implying that feedback cycles between government officials and public response should be shortened to rapidly maximize communication efficacy during the pandemic. Future research should identify and evaluate the drivers of the large differences in communication tone across states and validate the reactive characteristics of COVID-19 official communications.
Metformin-associated lactic acidosis and factors associated with 30-day mortality
Authors: Thammavaranucupt Kanin , Phonyangnok Boonchan , Parapiboon Watanyu , Wongluechai Laddaporn , Pichitporn Watthikorn , Sumrittivanicha Jirut , Sungkanuparph Somnuek , Nongnuch Arkom , Jayanama Kulapong 
Published: August 2022

Background
Metformin-associated lactic acidosis (MALA) is a rare event but underrecognition may lead to unfavorable outcomes in type 2 diabetes patients. While many risk factors of MALA have been identified, how to reduce mortality from MALA is a matter of debate. This study aimed to explore the factors associated with 30-day mortality amongst MALA patients.

Methods
An observational study enrolled patients diagnosed with MALA between January 2014 and December 2017. MALA was defined by a history of metformin administration, metabolic acidosis (arterial blood gas pH <7.35 or HCO3 <15 mmol/L), and elevated plasma lactate level (>5 mmol/L). We examined risk factors including age, sex, underlying diseases, current medications, blood tests, disease severity, and dialysis data. Mortality status was identified from medical records or report on telephone.

Results
We included 105 MALA patients. Most patients (95.2%) were diagnosed acute kidney injury stage 3 according to KDIGO 2012 definition. The 30-day mortality rate was 36.2% and dialysis rate was 85.7%. The survivors had higher proportions of underlying chronic kidney disease, presence of metabolic acidosis, receiving renal replacement therapy within 6 hours, and haemodialysis, whereas the non-survivors had higher percentage of hypertension and disease severity. Lower APACHE II score (HR = 0.95; 95%CI, 0.91–0.99; p = 0.038), time to dialysis < 6 hours (0.31; 0.14–0.69; 0.004), and haemodialysis (0.20;0.06–0.67; 0.010) were associated with lower 30-day mortality, using multivariate Cox-regression analysis.

Conclusions
Mortality rate amongst patients with MALA was high. Early dialysis treatment within 6 hours after admission and haemodialysis were independently associated with lower 30-day mortality. The large scale, well-designed studies need to confirm these encouraging results.
Retinal thickness in healthy Australian Aboriginal and Torres Strait Islander children
Authors: Cox Rebecca A. , Read Scott A. , Hopkins Shelley , Alonso-Caneiro David , Wood Joanne M. 
Published: August 2022

Background
Understanding normative retinal thickness characteristics is critical for diagnosis and monitoring of pathology, particularly in those predisposed to retinal disease. The macular retinal layer thickness of Australian Aboriginal and/or Torres Strait Islander children was examined using spectral-domain optical coherence tomography.

Methods
High-resolution macular optical coherence tomography imaging was performed on 100 Aboriginal and/or Torres Strait Islander children and 150 non-Indigenous visually healthy children aged 4–18 years. The imaging protocol included a 6-line radial scan centred on the fovea. Images were segmented using semi-automated software to derive thickness of the total retina, inner and outer retina, and individual retinal layers across the macular region. Repeated measures ANOVAs examined variations in thickness associated with retinal region, age, gender and Indigenous status.

Results
Retinal thickness showed significant topographical variations (p < 0.01), being thinnest in the foveal zone, and thickest in the parafovea. The retina of Aboriginal and/or Torres Strait Islander children was significantly thinner than non-Indigenous children in the foveal (p < 0.001), parafoveal (p = 0.002), and perifoveal zones (p = 0.01), with the greatest difference in the foveal zone (mean difference: 14.2 μm). Inner retinal thickness was also thinner in Aboriginal and/or Torres Strait Islander children compared to non-Indigenous children in the parafoveal zone (p < 0.001), and outer retinal thickness was thinner in the foveal (p < 0.001) and perifoveal zone (p < 0.001). Retinal thickness was also significantly greater in males than females (p < 0.001) and showed a statistically significant positive association with age (p = 0.01).

Conclusion
There are significant differences in macular retinal thickness between Aboriginal and/or Torres Strait Islander children and non-Indigenous children, which has implications for interpreting optical coherence tomography data and may relate to risk of macula disease in this population.
Early-Life Mebendazole Exposure Increases the Risk of Adult-Onset Ulcerative Colitis: A Population-Based Cohort Study
Authors: Agrawal Manasi , Allin Kristine H. , Iversen Aske T. , Mehandru Saurabh , Colombel Jean-Frederic , Jess Tine 
Published: August 2022

INTRODUCTION:
According to the hygiene hypothesis, exposure to parasites may protect against inflammatory bowel disease (IBD). Our aim was to examine the risk of IBD with childhood exposure to mebendazole, a broad-spectrum antihelminthic agent.

METHODS:
We conducted a population-based cohort study using prospectively collected historical data of all individuals born in Denmark between 1995 and 2018. We identified mebendazole exposure at age younger than 18 years and during early life (younger than 5 years). We performed adjusted Cox proportional hazards regression analysis to determine the risk of IBD, ulcerative colitis (UC), and Crohn's disease with mebendazole exposure after adjusting for potential confounders.

RESULTS:
Of 1,520,290 individuals in the cohort, 615,794 had childhood or adolescence mebendazole exposure. One thousand five hundred fifty-five and 1,499 individuals were subsequently diagnosed with pediatric-onset and adult-onset IBD, respectively. On multivariable analysis, mebendazole exposure at age younger than 18 years did not affect pediatric-onset or adult-onset IBD risk (adjusted hazard ratio [aHR] 0.97, 95% confidence interval [CI] 0.87, 1.07, and 1.08, 95% CI 0.97, 1.19, respectively). On limiting mebendazole exposure to age younger than 5 years while there was no association with pediatric-onset IBD (aHR 0.98, 95% CI 0.87, 1.11), adult-onset IBD risk was increased (aHR 1.17, 95% CI 1.04, 1.31). This increase in risk was driven by UC (aHR 1.32, 95% CI 1.12, 1.55), but not Crohn's disease (1.03, 95% CI 0.87, 1.22).

DISCUSSION:
Early-life mebendazole exposure is associated with an increase in the risk of adult-onset UC. These findings suggest the importance of early-life exposures in shaping the risk of IBD later in life.
The Impact of Biopharmaceutical Innovation on Disability, Social Security Recipiency, and Use of Medical Care of U.S. Community Residents, 1998–2015
Authors: Lichtenberg Frank R. 
Published: August 2022

Abstract
This study seeks to analyze the overall impact that biopharmaceutical innovation had on disability, Social Security recipiency, and the use of medical services of U.S. community residents during the period 1998–2015. We test the hypothesis that the probability of disability, Social Security recipiency, and medical care utilization associated with a medical condition is inversely related to the number of drug classes previously approved for that condition. We use data from the 1998–2015 waves of the Medical Expenditure Panel Survey and other sources to estimate probit models of an individual’s probability of disability, Social Security recipiency, and medical care utilization. The effect of biopharmaceutical innovation is identified by differences across over 200 medical conditions in the growth in the lagged number of drug classes ever approved. 18 years of previous biopharmaceutical innovation is estimated to have reduced: the number of people who were completely unable to work at a job, do housework, or go to school in 2015 by 4.5%; the number of people with cognitive limitations by 3.2%; the number of people receiving SSI in 2015 by 247 thousand (3.1%); and the number of people receiving Social Security by 984 thousand (2.0%). Previous innovation is also estimated to have caused reductions in home health visits (9.2%), inpatient events (5.7%), missed school days (5.1%), and outpatient events (4.1%). The estimated value in 2015 of some of the reductions in disability, Social Security recipiency, and use of medical care attributable to previous biopharmaceutical innovation ($115 billion) is fairly close to 2015 expenditure on drug classes that were first approved by the FDA during 1989–2006 ($127 billion). However, for a number of reasons, the costs are likely to be lower, and the benefits are likely to be larger, than these figures.
NF90/NFAR (nuclear factors associated with dsRNA) – a new methylation substrate of the PRMT5-WD45-RioK1 complex
Authors: Cox Jan , Esser Lea Marie , Jüdt Maximilian , Schmitz Katharina , Reiffert Kaja , Grimmler Matthias , Stork Björn , Wesselborg Sebastian , Peter Christoph 
Published: August 2022

Abstract
Protein-arginine methylation is a common posttranslational modification, crucial to various cellular processes, such as protein-protein interactions or binding to nucleic acids. The central enzyme of symmetric protein arginine methylation in mammals is the protein arginine methyltransferase 5 (PRMT5). While the methylation reaction itself is well understood, recruitment and differentiation among substrates remain less clear. One mechanism to regulate the diversity of PRMT5 substrate recognition is the mutual binding to the adaptor proteins pICln or RioK1. Here, we describe the specific interaction of Nuclear Factor 90 (NF90) with the PRMT5-WD45-RioK1 complex. We show for the first time that NF90 is symmetrically dimethylated by PRMT5 within the RG-rich region in its C-terminus. Since upregulation of PRMT5 is a hallmark of many cancer cells, the characterization of its dimethylation and modulation by specific commercial inhibitors in vivo presented here may contribute to a better understanding of PRMT5 function and its role in cancer.
An adaptive energy management strategy for supercapacitor supported solar-powered electric vehicle charging station
Authors: Satheesan Jithin , Thankappan Nair Rajeev 
Published: August 2022

Abstract
Large-scale electric vehicle integration into the grid is expected in the imminent future. Congestion caused by these integrations can be addressed through a hybrid AC/DC microgrid. The DC sub-grid is exclusively dedicated to incorporating electric vehicles. Solar-powered charging station supported with a supercapacitor energy storage system in the DC sub-grid reduces the stress on the AC sub-grid. This paper presents a hybrid AC/DC microgrid voltage/frequency stability improvement strategy based on adaptive DC-link voltage regulation assisted by energy storage. The proposed volatility-based approach is an efficient strategy to enhance the microgrid stability during generation intermittency and load fluctuations. The combined control scheme of the interlinking converter and supercapacitor energy storage in the independent and hybrid operation modes achieve energy balance with the variations in solar irradiation and the addition/disconnection of electric vehicles. The proposed energy management strategy is tested in real-time under various volatile conditions to validate the performance. The hybrid microgrid with proposed energy management strategy provided a frequency improvement of 0.55% and voltage improvement of 5.4%.
English as a global language?: Naturalization of English through intellectual habitus in Korean academia
Authors: Cho Jinhyun 
Published: August 2022

AbstractThe global expansion of English-medium lectures (EMLs) in higher education has predominantly been approached in the context of globalization characterized by neoliberalism. While the spread of EMLs has been viewed as an outcome of institutional pursuit of global competitiveness and internationalization, ongoing global approaches risk overlooking local elements critical for the ascendance of English in specific local contexts. This paper seeks to balance the scholarly inquiry into EMLs by offering a local historical perspective, with the higher education sector of South Korea as a key site of investigation. A focus is placed on the intellectual habitus of Korean higher education which the paper argues has served as a fertile ground for EMLs to take hold. Within the context of the global centre-periphery binary, the article specifically examines how the binary relationship has been internalized in Korean higher education through local historicity in which the U.S. has metaphorically been established as the centre. The superior-inferior binary divisions between the U.S. and Korea have contributed to the construction of the local intellectual habitus marked by the domination of American educated elite groups and the emergence of English as the language of the centre. In conclusion, the paper challenges the normative claim of English as a global language by illustrating EMLs in Korea as a historical-structural construct resulting from the interplays between the global and local power inequalities.
New understandings of the rise of English as a medium of instruction in higher education: the role of key performance indicators and institutional profiling
Authors: Hultgren Anna Kristina , Wilkinson Robert 
Published: August 2022

Abstract
The rise of English as a Medium of Instruction (EMI) has prompted concerns over linguistic injustice, educational disadvantage, societal inequality and epistemic homogenization. As EMI tends to generate heated debates, its drivers need to be better understood. Borrowing conceptual frameworks from political science, this article proposes a new understanding of the drivers of EMI, pointing to the introduction of new steering tools in the 1980s to govern Europe’s higher education institutions. Conducting Process Tracing in a Dutch university, and drawing on document analysis and interviews with nine “elite participants” – Ministers of Education, University Rectors, Members of the University Executive Board, Faculty Deans and Programme Leaders – we argue that the very first EMI programme at our case university may be traced back to a set of governance reforms in the Dutch higher education sector that introduced key performance indicators and institutional profiling. Responding to calls for linguists to engage with the political economy, we identify previously under-illuminated links between political processes and EMI. We conclude that close attention to the political economy is key to understanding the rise of EMI, and more generally language shift, and ultimately to tackling linguistic injustice that may follow in its wake.
Interactive annotation of geometric ornamentation on painted pottery assisted by deep learning
Authors: Lengauer Stefan , Houska Peter , Preiner Reinhold , Trinkl Elisabeth , Karl Stephan , Sipiran Ivan , Bustos Benjamin , Schreck Tobias 
Published: August 2022

Abstract
In Greek art, the phase from 900 to 700 BCE is referred to as the Geometric period due to the characteristically simple geometry-like ornamentations appearing on painted pottery surfaces during this era. Distinctive geometric patterns are typical for specific periods, regions, workshops as well as painters and are an important cue for archaeological tasks, such as dating and attribution. To date, these analyses are mostly conducted with the support of information technology. The primitives of an artefact’s ornamentation can be generally classified into a set of distinguishable pattern classes, which also appear in a similar fashion on other objects. Although a taxonomy of known pattern classes is given in subject-specific publications, the automatic detection and classification of surface patterns from object depictions poses a non-trivial challenge. Our long-term goal is to provide this classification functionality using a specifically designed and trained neural network. This, however, requires a large amount of labelled training data, which at this point does not exist for this domain context. In this work, we propose an effective annotation system, which allows a domain expert to interactively segment and label parts of digitized vessel surfaces. These user inputs are constantly fed back to a Convolutional Neural Network (CNN), enabling the prediction of pattern classes for a given surface area with ever increasing precision. Our work paves the way for a fully automatic classification and analysis of large surface pattern collections, which, with the help of suitable visual analysis techniques, can answer research questions like pattern variability or change over time. While the capability of our proposed annotation pipeline is demonstrated at the example of two characteristic Greek pottery artefacts from the Geometric period, the proposed methods can be readily adopted for the patternation in any other chronological periods as well as for stamped motifs.
Incidence tendency, etiological classification and outcome of congenital hypothyroidism in Guangzhou, China: an 11-year retrospective population-based study
Authors: Tan Min-Yi , Jiang Xiang , Mei Hui-Fen , Feng Yu-Yu , Xie Ting , Tang Cheng-Fang , Chen Qian-Yu , Zeng Chun-Hua , Huang Yonglan 
Published: August 2022

Abstract

Objectives
An increased incidence of congenital hypothyroidism (CH) has been described worldwide over the years. In this study, we aimed to investigate the epidemiologic characteristics of CH, the iodine status in Guangzhou, China and to investigate which factors might influence the CH incidence during the period 2010–2020.

Methods
We retrospectively reviewed all cases of CH detected by newborn screening during the period 2010–2020. CH was classified as either suspected thyroid dyshormonogenesis (SDH) or thyroid dysgenesis (TD) based on thyroid ultrasound at first diagnosis. Patients were re-evaluated after 4 weeks of L-thyroxine withdrawal at age of 2–3 years to confirm the diagnosis of permanent CH (PCH) or transient CH (TCH).

Results
From 2010 to 2020, 1,655 patients with CH were confirmed from 2,400,383 newborns (1:1,450). The CH incidence increased from 1:2,584 in period [2010–2014] to 1:1,086 in period [2015–2020]. Among the 1,337 patients with thyroid ultrasound, 84.29% were SDH whereas 15.71% had TD. Further analysis revealed that more SDH (78.32%) were TCH whereas more TD (87.12%) turned to be PCH. The proportion of blood spot thyrotropin values >5 mIU/L ranged from 8.03 to 20.46%, indicating iodine deficiency. The prevalence of preterm infants increased from 5.50% in period [2010–2014] to 7.06% in period [2015–2020] (p<0.001).

Conclusions
In the past decade, the CH incidence has increased progressively. SDH was the majority of CH, most of which were TCH, while most patients with TD were PCH. The increased incidence might be mainly due to iodine deficiency and increased rates of preterm infants in our study.
Two Notes on Composition
Authors: Biro John 
Published: August 2022

Abstract
If, as some philosophers maintain, there are no composites, we do not have to ask whether, as others hold, composition is identity. Here I argue that both groups are wrong: there are composites, and composition is not identity. I examine one argument for excluding composites from our ontology, based on their alleged causal redundancy. I give reason to think that composites are ineliminable in causal explanations of macroscopic effects. I go on to argue that the relation between composites and their components is not one of identity.
Theoretical analysis of aluminum honeycomb sandwich panel supported by reinforced concrete wall under low-speed impact load
Authors: Yang Ran , Zhang Jigang , Zhou Chenghao , Chen Wenli , Chen Jiguang , Zhao Yang 
Published: August 2022

Abstract
Honeycomb materials are widely used across engineering fields. The use of honeycomb sandwich structures as energy dissipation and impact protection materials for reinforced concrete components in the field of civil engineering is a novel concept. Therefore, it is of great significance to study the energy absorption characteristics, dynamic response theoretical model, and collapse energy dissipation theory for the use of honeycomb sandwich structures as protective materials. Based on the large-scale low-speed pendulum impact test and the corresponding finite element model, this study establishes an ideal model for the honeycomb sandwich panel under the impact of a square flat head and gives the corresponding theoretical derivation. At the same time, it puts forward a method to estimate the energy consumption and dynamic crushing distance based on the energy consumption theory angle of the covering layer.
Metadiscourse: the evolution of an approach to texts
Authors: Hyland Ken , Jiang Feng (Kevin) 
Published: August 2022

Abstract

Metadiscourse is the commentary on a text made by its producer in the course of speaking or writing, revealing something of how communication involves the personalities, attitudes and assumptions of those who are communicating. It offers a framework for understanding communication as social engagement and helps reveal how writers and speakers consider their audience in creating texts. This paper uses a bibliometric analysis to trace the growing interest in metadiscourse since its early incarnations in the 1980s. To do so we analysed all 431 papers relating to metadiscourse in the core collection of the Web of Science between 1983 and 2020, dividing the corpus into two periods following the massive increase in interest after 2006. We identify which topics have been most prevalent, which authors and publications most influential and which disciplines and journals most active in citing the metadiscourse literature. The findings show the importance of academic and business writing, cross-disciplinary, language and genre studies, and the increasing predominance of an interpersonal model. These findings may be of interest to those working in discourse analysis and the study of social interaction.