bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the contribution of case study research to the evidence base for occupational therapy practice: a scoping review
Authors: McQuaid Leona , Thomson Katie , Bannigan Katrina 
Published: July 2022

Abstract
Background: Case study research is generating interest to evaluate complex interventions. However, it is not clear how this is being utilized by occupational therapists or how feasible it is to contribute to the evidence base. This scoping review explores the range and characteristics of case study research within occupational therapy and examines how it is defined, methodologies adopted and practice contexts in which it is applied. We consider the viability of case study research for contributing to our evidence base.Methods: Opinion, text and empirical studies within an occupational therapy practice context were included. A three-step extensive search following Joanna Briggs Institute methodology was conducted in June 2020 and updated in July 2021 across ten databases, websites, peer reviewed and grey literature from 2016 onwards. Study selection was completed by two independent reviewers. A data extraction table was developed and piloted and data charted to align with research questions. Data extraction was completed by one reviewer and a 10% sample cross checked by another.Results: Eighty-eight studies were included in the review consisting of (n=84) empirical case study and (n=4) non-empirical papers. Case study research has been conducted globally, with a range of populations across different settings. The majority were conducted in a community setting (57%) with populations experiencing neurodevelopmental disorder (38%), stroke (17%) and non-diagnosis specific (15%). Methodologies adopted quantitative (50%), mixed methods (26%) and qualitative designs (24%). However, identifying the methodology and ‘case’ was a challenge due to methodological inconsistencies. Conclusions: Case study research is useful when large scale inquiry is not appropriate; for cases of complexity, early intervention efficacy, theory testing or when small participant numbers are available. It appears a viable methodology to contribute to the evidence base for occupation and health as it has been used to evaluate interventions across a breadth of occupational therapy practice contexts. Viability could be enhanced through consistent conduct and reporting to allow pooling of case data. A conceptual model and description of case study research in occupational therapy is proposed to support this. Scoping review registration: Open Science Framework 10.17605/OSF.IO/PCFJ6
A mental health-informed, online health promotion program targeting physical activity and healthy eating for adults aged 60+ years: study protocol for the MovingTogether randomised controlled trial
Authors: Mastrogiovanni Chiara , Rosenbaum Simon , Delbaere Kim , Tiedemann Anne , Teasdale Scott , McGavin Annaliese , Briggs Nancy , McKeon Grace 
Published: July 2022

Abstract
Background
The COVID-19 pandemic and associated social distancing regulations have led to an increased risk of social isolation and physical inactivity, particularly among older adults. The benefits of physical activity for reducing fall risk and improving mood and mental functioning have been well documented. The aim of this trial is to investigate the effect of the MovingTogether program on psychological distress (primary outcome) and physical activity, social capital, cognition, concern about falling, loneliness, physical functioning, quality of life and physical activity enjoyment (secondary outcomes).
Methods
A randomised controlled trial with a waitlist control will be conducted, recruiting 80 adults aged 60 + years with access to Facebook and a computer or tablet and not currently meeting the aerobic physical activity guidelines. Randomisation will be completed using REDCap. The intervention group (n = 40) will join a private Facebook group where allied health facilitators will provide targeted healthy lifestyle education throughout the 10-week program with weekly telehealth group calls. Intervention participants will also be provided access to tailored strength and aerobic exercise guidance and an evidence-based eHealth balance exercise program. Psychological distress and secondary outcomes will be assessed at baseline, 11 weeks (post intervention) and 16 weeks (one month follow-up). Linear mixed models will be applied for each outcome measure as per an intention-to-treat approach to determine between group differences. Secondary analyses are planned in people with greater adherence and those with higher psychological distress.
Discussion
COVID-19 has highlighted the need for a scalable, effective, and novel methods to improve and protect the health of older adults. The integration of an evidence-based falls prevention program with a mental health-informed online health promotion program may help to improve mental and physical health outcomes among older adults.
Trial registration:
ACTRN12621001322820p (Australian New Zealand Clinical Trials Registry, ANZCTR) on 29/09/2021.
In vitro shoot organogenesis in sweet orange (Citrus sinensis L.) cv. Mosambi and the effect of ethylene adsorbents on micro-shoot quality
Authors: Prusty Reena , AWASTHI OM PRAKASH , Singh Sajnjay Kumar , Kumar Kanika 
Published: July 2022

Abstract
An improved organogenesis protocol for multiplication of sweet orange cv. Mosambi has been standardized by the use of different PGRs, basal media and ethylene adsorbents. Incorporation of both cytokinins, BAP (8.8µM) and kinetin (6.97µM) resulted in best shoot organogenesis with the highest response (81.40%), No. of micro-shoots/explant (2.06), mean micro-shoot length (1.30 cm) and No. of leaves/micro-shoot (3.55) owing to synergistic effect of these factors. However, the regenerated micro-shoots failed to establish due to 100% leaf abscission on micro-shoot. To retard the effect of ethylene accumulation on the regenerated micro-shoots, two types of ethylene adsorbents carrying silver ions, namely, AgNO3 and Ag2S2O3 and two gelling agents (agar-agar and Phytagel™) were tested at different concentrations. Addition of AgNO3 (5.88µM) to the medium containing Phytagel™ along with cytokinin (BAP 8.8µM and kinetin 6.97µM) led to significant reduction in shoot abscission rate (4.20), while 17.66µM AgNO3 supplementation improved No. of micro-shoots/explants (2.19) and micro-shoot length (3.36 cm) whereas Ag2S2O3 at 20µM enhanced the total chlorophyll content (3.47 mg g− 1 FW) three times as compared to control. Similarly, among the tested basal media, MS basal medium induced best response on shoot organogenesis. Rooting of micro-shoots was highest (81.12%) with the supplementation of NAA (5.37µM), which also affected No. of roots/explant (4.52) and mean root length (5.26 cm). The supplementation of ethylene adsorbents during in vitro micro-shoot multiplication significantly improved their quality, which provides ideal rooting for development of complete plantlets in sweet orange cv. Mosambi.
Defunctioning stoma in anterior resection for rectal cancer does not impact anastomotic leakage: a national population-based cohort study
Authors: Munshi Eihab , Lydrup Marie-Louise , Buchwald Pamela 
Published: July 2022

Abstract
Background: Anterior resection (AR) is considered the gold standard for curative cancer treatment in the middle and upper rectum. The goal of the sphincter-preserving procedure, such as AR, is vulnerable to anastomotic leak (AL) complications. Defunctioning stoma (DS) became the protective measure against AL. Often a defunctioning loop-ileostomy is used, which is associated with substantial morbidity. However, not much is known if the routine use of DS reduces the overall incidence of AL.Methods: Elective patients subjected to AR in 2007- 2009 and 2016-18 were recruited from the Swedish colorectal cancer registry (SCRCR). Patient characteristics, including DS status and occurrence of AL, were analyzed. In addition, independent risk factors for AL were investigated by multivariate regression.Results: The statistical increase of DS from 71.6% in 2007-2009 to 76.7% in 2016-2018 did not impact the incidence of AL (9.2% and 8.2%), respectively. DLI was constructed in more than 35% of high-located tumors ≥11cm from the anal verge. Multivariate analysis showed that male gender, ASA 3-4, BMI >30 kg/m2, and neoadjuvant radiation were independent risk factors for AL.Conclusion: The role of routine DS in decreasing overall AL after AR procedure was not evident. A selective decision algorithm for DS construction is needed to protect from AL and mitigate DS morbidities.
Effectiveness and safety of acupuncture to treat sleep difficulties in women on hormone replacement therapy for the treatment of breast cancer: a randomized controlled trial
Authors: Mazzotti Eva , Jacoangeli Fabrizio , Sebastiani Claudia , Scoppola Alessandro , Cerruti Massimo , Castellucci Patrizia , Menichelli Franco , Marchetti Paolo 
Published: July 2022

Abstract
Sleep difficulties are commonly reported by cancer patients as consequences of cancer or its treatments. Aim of this study was to measure the effectiveness and safety of acupuncture to treat sleep difficulties in breast cancer women on hormone replacement therapy. Methods: 58 breast cancer women were randomized to once weekly acupuncture session for 8 weeks (acupuncture group) or to a standard care session once a week, for 8 weeks (control group). The primary endpoint was change in sleep difficulties and insomnia, as measured by the Insomnia Severity Index (ISI), administered at baseline and 8 weeks later. Results: Random assignment produced equivalent groups regarding demographic and clinical characteristics at baseline. After 8 weeks, the changes in sleep quality and quantity were significantly different in the two groups. In the acupuncture group 43.33% go into complete remission (absence of insomnia), but none in the control group, and the mean ISI score decreased from 15.87 (standard deviation, SD= 3.95) to 9.80 (SD= 6.22), in the acupuncture group versus 17.46 to 15.39. No patient reported any problems or discomfort associated with acupuncture. Conclusion: A weekly session of acupuncture may have beneficial effects on quality and quantity of sleep among breast cancer women on hormone replacement therapy, after 8 weeks. The results could have important implications for Public Health to prioritize promotion of healthy sleep and acupuncture may be considered as alternative intervention in healthcare setting to ameliorate cancer patients’ sleep and quality of life.
3D melanoma spheroid model for the development of positronium biomarker
Authors: Karimi Hanieh , Moskal Pawel , Stepien Ewa 
Published: July 2022

Abstract
It was recently demonstrated that newly invented positronium imaging may be used for improving cancer diagnostics by providing additional information about tissue pathology with respect to the standardized uptake value currently available in positron emission tomography (PET). Positronium imaging utilizes the properties of positronium atoms, which are built from the electron and positron produced in the body during PET examinations. We hypothesized whether positronium imaging would be sensitive to in vitro discrimination of tumor-like three-dimensional structures (spheroids) built of melanoma cell lines with different cancer activity and biological properties. The lifetime of ortho-Positronium (o-Ps) was evaluated in melanoma spheroids from two cell lines (WM266-4 and WM115) differing in the stage of malignancy. Additionally, we considered such parameters: as cell size, proliferation rate and malignancy to evaluate their relationship with o-Ps lifetime. We demonstrate the pilot results for the o-Ps lifetime measurement in extracellular matrix free spheroids. With the statistical significance of two standard deviations, we demonstrated that the higher the degree of malignancy and the rate of proliferation of neoplastic cells the shorter the lifetime of ortho-positronium. In particular we observed following indications encouraging further research: (i) WM266-4 spheroids characterized by higher proliferation rate and malignancy showed shorter o-Ps lifetime compared to WM115 spheroids characterized by the lower growth rate, (ii) Both cell lines showed a decrease in the lifetime of o-Ps after spheroid generation in 8th day comparing to 4th day in culture and the mean o-Ps lifetime is longer for spheroids formed from WM115 cells than these from WM266-4 cells, regardless spheroid age. The results of this study revealed that positronium is a promising biomarker that may be applied in PET diagnostics for the assessment of the degree of cancer malignancy.
Evaluation of social-economic inequality in the high CVD risk population with or without diabetes in China
Authors: Zhou Ziai , Xu Haibao , Mai Xingsheng , Hou Zeyi , Wang Yongjuan , Liang Xuanyi , Gao Yanpei , Yang Chenyu , Yang Jinyu , Li Chao , Guo Sujuan 
Published: July 2022

Abstract
Background
Epidemiological data showed that the comorbidities of cardiovascular disease and diabetes in China are very serious, but the comprehensive management of such patients is seriously inadequate and lack of standardization. Our study aimed to estimate the inequalities of those high CVD risk patients with or without diabetes in China, and analyze the contributors of inequalities problems.
Method
Data were derived from China Health and Retirement Longitudinal Study (CHARLS) conducted in 2011. The criteria of American Systolic Blood Pressure Intervention Trial (SPRINT) were used to estimate the prevalence of high CVD risk patients with or without diabetes in China. Concentration index was calculated to describe the economic-related inequality degree in high CVD risk patients with or without diabetes. A decomposition method was employed to analyze the cause of inequalities problems.
Results
The prevalence of high CVD risk patients with or without diabetes in China were 3.46% and 22.03% respectively. The concentration index of high CVD risk patients with or without diabetes in China were 0.0639 [ 95% CI: (0.0630, 0.0648)] and − 0.0628 [95% CI: (-0.0629, -0.0627)] respectively, indicating a pro-rich inequality in high CVD risk patients with diabetes and a pro-poor inequality in high CVD risk patients without diabetes. Location(rural or urban), age and BMI were the key factors to influence the pro-rich inequality in high CVD risk patients with diabetes. Age, socioeconomic status and education were the key factors to influence the pro-poor inequality in high CVD risk patients without diabetes.
Conclusion
Our study determined pro-rich inequality in high CVD risk patients with diabetes, but pro-poor in high CVD-risk without diabetes patients in China. SES and BMI mainly associated with the social-economic inequality in high CVD risk patients with or without diabetes.
Losses from fluvial floods in Poland over the 21st century – estimation using the productivity costs method
Authors: Gaska Jan 
Published: July 2022

Abstract
This paper aims at estimation of the impact of climate change on future losses caused by fluvial floods in Poland over the XXI century at the local level with the productivity costs valuation method. using the daily data on river discharges published by Piniewski et al. (2017), map of flood risk and value added generated in each county to produce county-level estimates of the impact of climate change on the fluvial flood damage. Even though there is some research published by Alfieri et al. (2016) or Feyen et al. (2012), their papers value the costs of future floods using the reconstruction cost method. This study aims to supplement their findings with estimates of future flood losses in Poland using the productivity costs valuation that considers also the costs of disruptions of production chains and lost production in given areas. This method shows the overall increase in losses caused by fluvial floods in Poland due to climate change in comparison to the reference period of 1974–2000 by 47% in RCP4.5 and 83% in RCP8.5 scenario in 2024–2050 and by 32% in RCP4.5 and 51% in RCP8.5 in 2074–2100.
Fatalism and Wellbeing during the COVID-19 Pandemic: Conditional Effects of Loneliness
Authors: Ayala Rafael Miranda , Torrelles-Nadal Cristina , Lazo Giancarlo Magro , Guiu Gemma Filella 
Published: July 2022

Abstract
The COVID-19 global crisis has put in danger more than our physical health. With containment measures people became more isolated, reducing drastically their daily social interactions. Many studies have already documented the negative impacts of these measures, highlighting fatalism. However, studies that linked the effect of this negative impact to well-being indicators are still limited. In this sense, the aim of this study is to explore the relationship between fatalism associated with COVID-19 and well-being indicators, as well as the moderating role of loneliness in this relationship. Data were collected from 1,036 adults living in Peru through an online survey that includes the Quality-of-life index, the Fatalism facing COVID-19 scale, the Loneliness Scale and the Scale for Mood Assessment. Three models were tested using linear regression and ordinary least squares with bias-corrected bootstrapping. The results confirm that fatalism has a negative effect on quality of life and a positive effect on negative affect, and that loneliness mediates both relationships, supporting the increase of fatalism the effect over well-being indicators and negative affect.
Discovery of Amino Acid fingerprints transducing their amphoteric signatures by field-effect transistors
Authors: García César Pascual , Kumar Naveen , Dhar Rakshita , Georgiev Vihar 
Published: July 2022

Abstract
Protein sequencing is key to advance science and prospect medical applications but even advanced techniques such as mass spectrometry do not provide wide access to ex-Novo sequencing of low quantities of proteins. We are presenting a disruptive method based on Field Effect Transistor (FET) sensors for Amino Acid (AA)/polypeptide identification using calculations of the modification of surface potential and capacitance. We show fingerprints of every single AA and signatures of polypeptide mutations immobilized on the FET surface by solving the site-binding model self-consistently with the Gouy-Chapman-Stern model. These fingerprints are based on orthogonal properties of the AAs, which are the different proton affinities of each of the radicals, the dielectric constant and effective length, which is sensitive to the relative positions of the radicals to distinguish between isomers. The calculations of typical sensor conditions show that FETs can provide a measurable signal even for quantities approaching a single molecule.
Framework for Document Traceability in Chemical Supply Chain Using Blockchain and Smart Contracts
Authors: Manoharan Yokaraj , Priya S.Manju 
Published: July 2022

Abstract
In today’s world, 96% of all goods depend on chemicals. Chemical industry plays vital role in supply chain. Chemical supply chain consists of multiple stakeholders including raw material suppliers to end user customers. Based on regulations, several product documents are needed to be supplied with the chemicals till the end of the life cycle. Blockchain based document traceability offers a viable solution to create a decentralized distributed shared platform for a secure, immutable, transparent, permanent, trustworthy, and accountable system for all the stakeholders involved. In this paper, an overview of the document traceability, current challenges and envisage how Blockchain and smart contracts address those challenges are presented. Based on the analysis, it is proposed to use using Hyperledger Fabric, an open-source private blockchain to meet the document traceability requirements such as security, privacy, scalability, authentication, and authorization. The proposed Blockchain architecture provides a feasible solution to build and deploy an end-to-end decentralized application in the chemical supply chain industry for document traceability.
Cortical Change After a 2-week Novel Robotic Rehabilitation Program in Children with Prior Hemispherectomy: Pilot Imaging Study
Authors: Hazany Saman , Mann Daljit , Bagrodia Neelesh , Krafnick Anthony J. , Chu Remy , Shaw Susan , Klark Kristi 
Published: July 2022

Abstract
Introduction: Partial preservation of sensory and motor functions in the contralateral extremities after hemispherectomy is likely secondary to cortical reorganization of the remaining hemisphere and can be improved by rehabilitation. This study aims to investigate behavioral and structural cerebral cortical changes that may occur after a 2-week novel robotic rehabilitation program in children with prior anatomic hemispherectomy.Methods: Five patients with prior anatomic hemispherectomy (average age 10.8 years; all female) participated in a 2-week novel robotic rehabilitation program. Pre- and post-treatment (2 time points) high-resolution structural 3D FSPGR (fast spoiled gradient echo) magnetic resonance images were analyzed to measure cortical thickness and gray matter volume using a locally designed image processing pipeline.Results: Four of the five patients showed improvement in the Fugl-Meyer score (average increase 2.5 + 2.1 SD. Individual analyses identified small increases in gray matter volume near the hand knob area of the primary cortex in three of the five patients. Group analyses identified an increase in cortical thickness near the hand knob area of the primary motor cortex, in addition to other sensorimotor regions.Conclusion: This small pilot study demonstrates that potentially rehabilitation-associated cortical changes can be identified with MRI in hemispherectomy patients.