bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of serum HBV RNA in non‐cirrhotic HBeAg‐negative chronic hepatitis B patients who discontinue effective antiviral therapy
Authors: Papatheodoridi Margarita , Papachristou Eleni , Moschidis Zissis , Hadziyannis Emilia , Rigopoulou Eirini , Zachou Kalliopi , Villeret François , Magiorkinis Gkikas , Lyberopoulou Aggeliki , Gatselis Nikolaos , Vlachogiannakos Ioannis , Manolakopoulos Spilios , Dalekos George N. , Zoulim Fabien , Paraskevis Dimitrios , Papatheodoridis George V. 
Published: July 2022

AbstractHBV RNA is considered as a promising predictor in patients who discontinue nucleos(t)ide analogues (NAs). We determined HBV RNA levels in non‐cirrhotic HBeAg‐negative patients who discontinued NAs and assessed their predictability for 12‐month outcomes. Fifty‐seven patients of DARING‐B study were included. HBV RNA levels were determined in stored monthly serum samples drawn at 0–3 months after end of therapy (EOT). Other markers previously determined in the same cohort including hepatitis B core‐related antigen (HBcrAg) were also assessed. HBV RNA at EOT was detectable in 7% of patients, who developed virological/clinical relapse and required retreatment at month 2; in patients with undetectable EOT HBV RNA, 12‐month cumulative rates of virological relapse, clinical relapse and retreatment were 68%, 28% and 21%, respectively (p ≤ 0.008). HBV RNA at month‐1 after EOT was detectable in 19% of patients being associated with higher probability only of virological relapse (p = 0.001). HBV RNA levels correlated significantly to HBV DNA, HBcrAg, ALT and interferon‐induced protein‐10, but not HBsAg levels. Combined EOT HBV RNA and HBcrAg detection and/or HBsAg >1000 IU/ml was associated only with higher probability of retreatment having higher sensitivity and lower specificity than HBV RNA alone. In conclusion, serum HBV RNA is detectable in a minority of non‐cirrhotic HBeAg‐negative patients under effective long‐term NAs therapy offering low sensitivity but 100% specificity for early retreatment due to severe clinical relapses after NA discontinuation. The combinations of EOT HBV RNA with HBcrAg and/or high HBsAg levels increase sensitivity but decrease specificity for prediction of retreatment after NAs withdrawal.
Factors associated with venous thromboembolism in the paediatric intensive care unit: A systematic review and meta‐analysis
Authors: Wang Ya Jing , Lei Lei , Huang Yan 
Published: July 2022

AbstractBackgroundPaediatric critical care practitioners have become increasingly concerned about venous thromboembolism (VTE). Although a wide range of factors associated with VTE in paediatric intensive care units (PICUs) have been identified, the strength and consistency of effect sizes are uncertain.Study DesignSystematic review and meta‐analysis of case–control and cohort studies.We searched six electronic databases from inception to 20 June 2021. The study population consisted of hospitalized children aged 0–21 years. Our primary outcome was factors associated with VTE in the PICU. We pooled effect sizes as odds ratios (ORs) using random‐effects models for each factor that was examined in at least three distinct samples. We assessed study quality using the Newcastle–Ottawa Scale and examined between‐study heterogeneity.ResultsThe meta‐analysis showed that age <1 year (OR = 1.80, 95% confidence interval [CI]: 1.08–3.01), sepsis (OR = 3.14, 95% CI: 1.55–6.38), central venous catheterization (CVC; OR = 7.76, 95% CI: 3.63–16.61), and mechanical ventilation (OR = 2.80, 95% CI: 1.90–4.13) was associated with an increased VTE risk.ConclusionWe identified that infancy, sepsis, and the use of CVC and mechanical ventilation therapies are more likely to cause VTE in critically ill children. It is still necessary to identify the association between VTE and important clinical variables (e.g., postpubertal age, postoperative status).Relevance to Clinical PracticeThis review provides evidence that supports the factors associated with VTE in specific clinical settings and suggests that nurses should focus on the precise identification of the factors associated with VTE.
The changing face of abuse cases in a pediatric intensive care unit: A single‐center experience
Authors: Varol Fatih , Sahin Ebru , Ozgunay Busra , Cengiz Mehmet , Altas Zeynep Meva , Guven Sirin 
Published: July 2022

AbstractBackgroundDue to the increase in abuse and neglect cases in recent years, the purpose of this study was to assess child abuse and neglect of patients who were hospitalized and followed up in our pediatric intensive care unit (PICU).MethodsA total of 34 abuse and neglect patients who were admitted to the PICU from August 2020 to March 2021 were included retrospectively in the study. Patients’ clinical and demographic characteristics were obtained from our hospital's patient record system (HIS). Comorbidities and the mental status of the patients, affected systems, treatments, and outcomes were extracted.ResultsIn this study, 44.1% (n: 15) of the patients were male and 55.9% (n: 19) were female. Physical neglect such as foreign body aspiration, malnutrition, electrocution, drowning, traffic accident, and body collision was detected in 14 (41.2%) patients. Emotional neglect (taking drugs, alcohol, or suicide) was found in 19 (55.9%) of our patients. Only 1 (2.9%) patient presented with physical abuse.ConclusionsPerception of neglect varies among different cultures. Any infant or child who is admitted to the PICU with a history that is not consistent, a history of delay in seeking medical attention, a previous history of abuse or suspected abuse, or the absence of the primary caretaker at the appearance of illness should signal possible abuse. Health‐care professionals should give more attention to these patients to prevent the overlooking and recurrence of neglect and abuse cases due to the intense work tempo in the PICU.
One President at a Time? How the President‐Elect Shapes U.S. Foreign Policy during the Transition
Authors: Michaels Jeffrey H. , Payne Andrew 
Published: July 2022

AbstractOver the past six decades, the presidential transition scholarship has grown increasingly rich, yet little systematic attention has been paid to the foreign policy activities of the president‐elect. The idea that the United States has “one president at a time” may be a constitutional reality, but it is also a political fiction, more honored in the breach than in the observance. This article demonstrates how U.S. foreign policy operates along several simultaneous tracks during the formal transition period between the election and inauguration. We develop and illustrate a new framework for understanding the underexplored role and significance of the president‐elect as a foreign policy actor during the era of the “modern presidency.” By refuting the notion that the president‐elect is a nonentity, this article lays the foundation for more active exploration of the foreign activities of presidents‐elect and their impact on U.S. foreign policy.
General purpose multiply robust data integration procedures for handling nonprobability samples
Authors: Chen Sixia , Haziza David 
Published: July 2022

AbstractIn recent years, there has been an increased interest in combining probability and nonprobability samples. Nonprobability sample are cheaper and quicker to conduct but the resulting estimators are vulnerable to bias as the participation probabilities are unknown. To adjust for the potential bias, estimation procedures based on parametric or nonparametric models have been discussed in the literature. However, the validity of the resulting estimators relies heavily on the validity of the underlying models. Also, nonparametric approaches may suffer from the curse of dimensionality and poor efficiency. We propose a data integration approach by combining multiple outcome regression models and propensity score models. The proposed approach can be used for estimating general parameters including totals, means, distribution functions, and percentiles. The resulting estimators are multiply robust in the sense that they remain consistent if all but one model are misspecified. The asymptotic properties of point and variance estimators are established. The results from a simulation study show the benefits of the proposed method in terms of bias and efficiency. Finally, we apply the proposed method using data from the Korea National Health and Nutrition Examination Survey and data from the National Health Insurance Sharing Services.
Soil microbiome biomass, activity, composition and CO2 emissions in a long‐term organic and conventional farming systems
Authors: Santoni Margherita , Verdi Leonardo , Imran Pathan Shamina , Napoli Marco , Dalla Marta Anna , Dani Francesca Romana , Pacini Gaio Cesare , Ceccherini Maria Teresa 
Published: July 2022

AbstractThe implementation of environmentally friendly agricultural policies has increased the need to compare agricultural aspects of conventional (CON) and organic farming (ORG) systems. The objective of the present work was to compare the effects of an organic and conventional long‐term experiment on bacterial and fungal biomass and activity, as well as soil CO2 emission and readily available nitrogen forms in a soil cultivated with Helianthus annuus L. The microbial biomass was more active and abundant in ORG as well as soil CO2 emission. Despite being less abundant, fungi were more active than bacteria in both ORG and CON experiments. 16S rRNA gene sequencing showed that the ORG treatment had a significantly greater bacterial richness than CON. Cyanobacteria, Actinobacteria and Proteobacteria were the most abundant phyla contributing more than others to the differences between the two systems. Moreover, the soil and content was not significantly different between ORG and CON, while was less in ORG. ORG sunflower yield was significantly less compared with CON. While much remains to be discovered about the effects of these agricultural practices on soil chemical properties and microbial diversity, our findings may contribute to this type of investigation.
Development of novel mixed matrix membranes (MMMs) for oil sands wastewater treatment: A critical review
Authors: Bui Vu Tan , Eduok Ubong , Abdelrasoul Amira , McMartin Dena W. 
Published: July 2022

AbstractWhile oil sands production plays a significant role in Canada's economy, the rise in oil sands production leads to increasing water withdrawal, consumption, storage and contamination that threaten the sustainability of water sources, biodiversity, ecosystem and public health. Effective treatment and reuse of oil sands process‐affected water (OSPW) can be a strategic solution for these issues. Membrane technology has emerged as a favourite choice for OSPW treatment with high removal and energy efficiency, small footprint and facile operation, installation and scale‐up. However, challenges also exist for membrane technologies related to fouling that causes a rapid decline in membrane performance. Mixed matrix membranes (MMMs) prepared by mixing superhydrophilic zwitterionic materials and inorganic nanoparticles into host membranes are anticipated as next‐generation membrane designs with significant potential for OSPW treatment by achieving multifunctionalities including fouling resistance, improved water permeability, selectivity and mechanical strength. Reproducibility and feasibility for large‐scale industrial applications remain important research questions for the production of MMMs for OSPW treatment. This study provides new insight on the performance, stability and durability of MMMs, outlooking to the commercialization prospect of MMMs. The research outcomes therefore can provide valuable knowledge for the design and development of high‐quality membranes with the required characteristics for OSPW treatment applications.
Oculomotor plant and neural dynamics suggest gaze control requires integration on distributed timescales
Authors: Miri Andrew , Bhasin Brandon J. , Aksay Emre R. F. , Tank David W. , Goldman Mark S. 
Published: July 2022

AbstractA fundamental principle of biological motor control is that the neural commands driving movement must conform to the response properties of the motor plants they control. In the oculomotor system, characterizations of oculomotor plant dynamics traditionally supported models in which the plant responds to neural drive to extraocular muscles on exclusively short, subsecond timescales. These models predict that the stabilization of gaze during fixations between saccades requires neural drive that approximates eye position on longer timescales and is generated through the temporal integration of brief eye velocity‐encoding signals that cause saccades. However, recent measurements of oculomotor plant behaviour have revealed responses on longer timescales. Furthermore, measurements of firing patterns in the oculomotor integrator have revealed a more complex encoding of eye movement dynamics. Yet, the link between these observations has remained unclear. Here we use measurements from the larval zebrafish to link dynamics in the oculomotor plant to dynamics in the neural integrator. The oculomotor plant in both anaesthetized and awake larval zebrafish was characterized by a broad distribution of response timescales, including those much longer than 1 s. Analysis of the firing patterns of oculomotor integrator neurons, which exhibited a broadly distributed range of decay time constants, demonstrates the sufficiency of this activity for stabilizing gaze given an oculomotor plant with distributed response timescales. This work suggests that leaky integration on multiple, distributed timescales by the oculomotor integrator reflects an inverse model for generating oculomotor commands, and that multi‐timescale dynamics may be a general feature of motor circuitry.
imageKey points
Recent observations of oculomotor plant response properties and neural activity across the oculomotor system have called into question classical formulations of both the oculomotor plant and the oculomotor integrator.
Here we use measurements from new and published experiments in the larval zebrafish together with modelling to reconcile recent oculomotor plant observations with oculomotor integrator function.
We developed computational techniques to characterize oculomotor plant responses over several seconds in awake animals, demonstrating that long timescale responses seen in anaesthetized animals extend to the awake state.
Analysis of firing patterns of oculomotor integrator neurons demonstrates the sufficiency of this activity for stabilizing gaze given an oculomotor plant with multiple, distributed response timescales.
Our results support a formulation of gaze stabilization by the oculomotor system in which commands for stabilizing gaze are generated through integration on multiple, distributed timescales.
Computational Fluid Dynamics Modeling of a Pressurized Water Reactor Fuel Assembly to Estimate Loss Coefficients in Support of Subchannel Thermalhydraulics Modeling of Pressurized Water Reactor Small Modular Reactors With Advanced Fuels
Authors: Li Chenguang , Podila Krishna , Bromley Blair P. , Rao Yanfei 
Published: July 2022

Abstract
Pressure loss coefficients are generally required by subchannel and system thermalhydraulics codes. These coefficients are not readily available for small modular reactors (SMRs) featuring nonconventional designs and novel coolants. In this study, the pressure loss coefficients were obtained using three-dimensional (3D) computational fluid dynamics (CFD) modeling for an advanced water-cooled reactor. A representative light water fuel assembly used in the Organization for Economic Co-operation and Development (OECD)/National Research Council Canada (NRC) pressurized water reactor subchannel and bundle tests (PSBT) benchmark was selected for CFD modeling and simulation under various working conditions. The fuel assembly includes three types of pressurized water reactor (PWR) spacer grids: simple grid (SG), nonmixing vane grid (NMVG), and mixing vane grid (MVG). Turbulent flow through subchannels of both nonheated and heated rod bundles was simulated to predict recoverable and nonrecoverable pressure distribution along the length of the bundle. It was observed that vortices were generated at the tips of spacer grids, affecting the cross-flow in subchannels significantly. The estimated pressure loss coefficients were found to be influenced by the flow conditions (Reynolds number or the upstream flow history) and spacer grid configuration. Pressure loss coefficient values ranged from 1.14 to 1.80, depending on the spacer grid type, design, and flow conditions. The CFD method used in this study was demonstrated to have the potential to generate input parameters required for the subchannel analysis and optimization of fuel assembly designs and serve as a surrogate for empirical correlations.
Effect of the Carotenoid Content and Activity of the Carotene cis-trans Isomerase CRTISO on Tomato Fruit Color
Authors: Efremov G. I. , Dzhos E. A. , Ashikhmin A. A. , Kochieva E. Z. , Shchennikova A. V. 
Published: July 2022

Abstract
The tomato Solanum lycopersicum L. is a convenient model for studying carotenoid metabolism due to the wide variety of carotenoid-mediated pigmentation of the ripe fruit. Carotene cis-trans isomerase CRTISO catalyzes cis-trans isomerization of double bonds leading to the formation of all-trans-lycopene, which is the most powerful antioxidant among carotenoids and a substrate for subsequent synthesis of α-, β-carotenes, and xanthophylls. In this work, 18 accessions of tomato cultivars and lines differing in the color of ripe fruit have been analyzed. The obtained biochemical data showed a dependence of fruit color on the content and composition of carotenoids and the presence or absence of chlorophylls. Expression analysis of three CRTISO homologous genes performed in silico has shown that the highest expression level in the fruit is only characteristic of gene CRTISO that has the maximal transcription at the stages of color change (from green to red) and biological ripeness of the fruit. Quantitative real-time PCR did not reveal any strong correlation between the level of CRTISO gene expression and total carotenoids, which may be explained by a different quantity of metabolites preceding prolycopene.
Ex situ soil respiration assessment using minimally disturbed microcosms and dried–sieved soils; comparison of methods to assess soil health
Authors: Comeau Louis-Pierre , MacKinley Kyle , Unc Adrian , Vallotton Jeremiah 
Published: July 2022

Soil respiration measurements are commonly used as soil health indicators. Several ex situ soil respiration methods exist, but comparative performances between them have rarely been analyzed. Specifically, there is a lack of comparisons between intact microcosms and destructive methods. The objective of this study was to analyze and compare three different ex situ soil respiration methodologies: minimally disturbed microcosms using fresh soil, dried–sieved 24 h burst test, and dried–sieved 10-day incubation. We hypothesized that ( i) the respiration rates for the three methods are correlated to each other; ( ii) the respiration rates are strongly correlated with soil physico-chemical parameters; ( iii) disturbance caused by drying and sieving reduces regression coefficients compared with microcosms; and ( iv) drying and sieving soil produces larger respiration rates. Soil was collected in the Province of New Brunswick, Canada. Total carbon and nitrogen (C:N), pH, aggregate stability, total dissolved C and N, NO3 and NH4, texture, and labile C were determined prior to incubations. Our results showed that the three methods had CO2 efflux in similar ranges. However, all the methods had low to no significant correlations between soil physico-chemical parameters and respiration. Total dissolved N had the strongest correlation with CO2 efflux. The results of the microcosm method significantly correlated with the results for 24 h burst test but not with the 10-day incubation method. We conclude that drying and sieving soil prior to performing ex situ soil heterotrophic respiration measurements using the 24 h burst tests can produce cautiously reliable results. Despite the disturbance, results from the 24 h burst tests are comparable with the results of the microcosm method.
Long-Term Outcomes of Perioperative Versus Nonoperative Myocardial Infarction: A Danish Population-Based Cohort Study (2000–2016)
Authors: Korsgaard Søren , Schmidt Morten , Maeng Michael , Jakobsen Lars , Pedersen Lars , Christiansen Christian Fynbo , Sørensen Henrik Toft 
Published: July 2022

Background:
Perioperative myocardial infarction is a serious cardiovascular complication of noncardiac surgery. The clinical course of perioperative myocardial infarction, other than all-cause mortality, is largely unknown. We examined long-term fatal and nonfatal outcomes of perioperative myocardial infarction compared with nonoperative myocardial infarction.

Methods:
We conducted a population-based cohort study of first-time myocardial infarction in Denmark from 2000 to 2016. We calculated cumulative incidence of all-cause mortality, cardiac mortality, recurrent myocardial infarction, heart failure, stroke, venous thromboembolism, acute kidney injury, and kidney failure with replacement therapy. We computed 5-year risk ratios adjusted for age, sex, year of diagnosis, educational level, and comorbidities.

Results:
We identified 5068 patients with perioperative myocardial infarction and 137 862 patients with nonoperative myocardial infarction. The 5-year risk of all-cause mortality was 67.5% (95% CI, 66.1%–69.0%) for perioperative myocardial infarction patients and 38.0% (95% CI, 37.7%–38.3%) for nonoperative myocardial infarction patients. The adjusted risk ratio of all-cause mortality was 1.13 (95% CI, 1.11–1.16) at 5 years. After adjustment, we found no association between patients with perioperative myocardial infarction and 5-year cardiac mortality, recurrent myocardial infarction, heart failure, stroke, or kidney failure with replacement therapy when compared with nonoperative myocardial infarction patients. Perioperative myocardial infarction patients had a higher relative risk of venous thromboembolism (5-year risk ratio, 1.21 [95% CI, 1.01–1.46]) and acute kidney injury (5-year risk ratio, 1.37 [95% CI, 1.22–1.53]).

Conclusions:
Compared with nonoperative myocardial infarction patients, perioperative myocardial infarction patients had elevated risk of all-cause mortality, venous thromboembolism, and acute kidney failure. In addition to the myocardial infarction component of perioperative myocardial infarction, this poor prognosis seemed associated with the surgery or underlying comorbidities. These findings warrant further research on strategies to reduce the risk of perioperative myocardial infarction and on strategies to manage perioperative myocardial infarction.