bluuebunny/crossref_metadata_2025_split huggingface dataset:
CITRA PEREMPUAN DAN GAYA BAHASA DALAM KUMPULAN PUISI IBU MENDULANG ANAK BERLARI SEBAGAI MATERI PEMBELAJARAN SASTRA
Authors: Novena Yuvensia Kharisma , Suhita Raheni , Suryanto Edy 
Published: January 2022

<em>This research has purpose to describe and explain; (1) The position of woman figure in collection of poetry Ibu Mendulang Anak Berlari by Cyntha Hariadi. (2) The language style of Poetry in Ibu Mendulang Anak Berlari. (3) The collection of poetry Ibu Mendulang Anak Berlari that can be used in a poetry learning material in senior high school<strong>. </strong>This research used the method of qualitative. Data analysis of this research used interaktif analysis within 3 components: data reducing, Data validity test is done by triangulating theory and triangulation of the data source. Based on the results of the study can be concluded: (1) on the poetry collection of ibu mendulang anak berlari has (a) Physical figure, (b) Physcological Figure, and (c) Social Figure; (2) Repetition is the most dominant style that used in the Ibu Mendulang Anak berlari poetry collection; (3) Ibu Mendulang Anak Berlari poetry collection can be used as a poetry learning material in senior high school, especially on KD 3.16 (Identifying the atmosphere, theme, and the meaning of poetry that has been read) and KD 3.17 (Analyze the elements of poetry).</em>
ANALISIS WACANA TEKSTUAL DAN KONTEKSTUAL DALAM NASKAH DRAMA SENJA DENGAN DUA KELELAWAR KARYA KIRDJOMULYO DAN RELEVANSINYA SEBAGAI BAHAN AJAR DI SEKOLAH MENENGAH ATAS
Authors: Nuryani Nina , Setiawan Budhi , Saddhono Kundharu 
Published: January 2022

<em>The purpose of this study is to describe (1) the form of textual analysis in the drama script Senja dengan Dua Kelelawar by Kirdjomulyo; (2) the form of contextual analysis in the drama script Senja dengan Dua Kelelawar by Kirdjomulyo; and (3) the relevance of the results of this study as teaching materials for Indonesian language learning in senior high schools. This research is a qualitative research with the main data source as the drama script Senja dengan Dua Kelelawar by Kirdjomulyo. Data validity test used is theory triangulation. The sampling technique of this study used purposive sampling. Data analysis technique used is an interactive analysis technique that includes four stages, namely: (1) data collection, (2) data reduction, (3) data presentation, and (4) drawing conclusions. The results of this study indicate that in the drama script Senja dengan Dua Kelelawar by Kirdjomulyo uses grammatical and lexical aspects to analyze textually. The use of analysis of grammatical and lexical aspects is precisely able to form a discourse that has cohesive forms. The unified form of drama script discourse is supported by grammatical aspects, namely reference, restoration, absorption, and sequencing. In grammatical aspects, it is dominated by reference. Persona referencing that is often used is single persona referencing, both my free form, mine, my left sticky form, and my right sticky form. Harmony of meaning is also supported by lexical aspects, namely repetition, synonymy, antonymy, collocation, hyponymy, and equivalence.</em>
KONFLIK BATIN DAN NILAI PENDIDIKAN NOVEL DI TANAH LADA KARYA ZIGGY ZEZSYAZEOVIENNAZABRIZKIE SERTA RELEVANSINYA DENGAN PEMBELAJARAN SASTRA DI SMA
Authors: Imani Wafda Nurul , Wardani Nugraheni Eko , Waluyo Herman J. 
Published: January 2022

<em>This study aims to describe: (1) characterization of the characters; (2) id from the inner conflicts of the characters; (3) ego from the inner conflicts of the characters; (4) super ego from the inner conflicts of the characters; (5) educational value; and (6) the relevance of novels Di Tanah Lada as the study for literacy in high school. The method used is descriptive qualitative. The sources come from documents and informants. The sampling technique uses purposive sampling. Writer used document analysis and interview techniques to collect data. Validation of the data is done by theory of triangulation and source triangulation. Analysis of the data used an interactive analysis technique. The results of the study can be described as follows. (1) The character of the characters in the novel Di Tanah Lada is varied, both in terms of character types and physiological, psychological and sociological dimensions; (2) Id in the inner conflict experienced by the character includes the pleasure of labeling others, conforming wild thoughts in the head, ignoring parental advice, and indulging indulgence in pleasure; (3) The ego in the inner conflicts experienced by the characters includes fulfilling curiosity and feeling guilty for the decision that's been taken; (4) Superego in the inner conflicts experienced by the characters include, recognizing the risk of his decision, succumbing to the common good, helping people in trouble, accepting the risk of their actions; (5) Educational values in drama scripts consist of religious, moral, social and cultural education values. The value of education is being dominated by the value of social education; (4) Novels Di Tanah Lada has been meet the standards for content, language, presentation, and graphic worthiness and can be pertained in literacy learning in class XI.</em>
Observations and Modeling of Fiber Optic Strain on Hydraulic Fracture Height Growth in Hydraulic Fracturing Test Site 2 (HFTS-2)
Authors: Wang Jiehao , Tan Yunhui , Rijken Margaretha , Liu Xinghui , Singh Amit , Li Yan 
Published: January 2022

Summary
Understanding fracture height growth can be of great significance to optimizing field development and improving recovery. The Hydraulic Fracturing Test Site 2 (HFTS-2) has provided a unique opportunity and an advanced data set to allow us to observe and understand fracture geometries rigorously. Low-frequency distributed acoustic sensing (LF-DAS) data from a vertical well in HFTS-2 showed three key observations: (i) excessive upward height growth (&gt;1,000 ft) and limited downward growth of the hydraulic fractures during pumping, (ii) considerable additional upward fracture height growth (~300 ft) after well shut in, and (iii) very complex LF-DAS strain rate patterns for a small fiber-to-stage offset. Advanced geomechanical modeling was performed to simulate the hydraulic fracture propagation and the resulting strain responses in the vertical direction. The modeling results demonstrated asymmetric upward and downward fracture height growths as observed in HFTS-2 with a similar upward height growth rate. Simulated waterfall plots of vertical strain rate showed distinct patterns for different fiber-to-fracture distances. The upward-growing fracture tip can be clearly identified by the interfaces between compressing and extending zones. It was also found that the complex strain rate patterns observed in HFTS-2 for small fiber-stage offsets were not caused by the mechanical layering but possibly result from the simultaneous propagation of multiple hydraulic fractures at different rates. The simulation results improved the understating of the HFTS-2 LF-DAS data, and the simulated strain rate patterns could also serve as templates for fracture height interpretation from LF-DAS data in future.
A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damage
Authors: Sarkar Gautam , Rautela Umanshi , Goyala Anita , Datta Sudeshna , Anand Nikhita , Singh Anupama , Singh Prachi , Chamoli Manish , Mukhopadhyay Arnab 
Published: January 2022

Abstract
Germline integrity is critical for progeny fitness. Organisms deploy the DNA damage response (DDR) signalling to protect germline from genotoxic stress, facilitating cell-cycle arrest of germ cells and DNA repair or their apoptosis. Cell-autonomous regulation of germline quality is well-studied; however, how quality is enforced cell non-autonomously on sensing somatic DNA damage is less known. Using Caenorhabditis elegans, we show that DDR disruption, only in the uterus, when insulin-IGF-1 signalling (IIS) is low, arrests germline development and induces sterility in a FOXO/DAF-16 transcription factor (TF)-dependent manner. Without FOXO/DAF-16, germ cells of the IIS mutant escape arrest to produce poor quality oocytes, showing that the TF imposes strict quality control during low IIS. In response to low IIS in neurons, FOXO/DAF-16 works cell autonomously as well as non-autonomously to facilitate the arrest. Activated FOXO/DAF-16 promotes transcription of checkpoint and DDR genes, protecting germline integrity. However, on reducing DDR during low IIS, the TF decreases ERK/MPK-1 signaling below a threshold, and transcriptionally downregulates genes involved in spermatogenesis-to-oogenesis switch as well as cdk-1/Cyclin B to promote germline arrest. Altogether, our study reveals how cell non-autonomous function of FOXO/DAF-16 promotes germline quality and progeny fitness in response to somatic DNA damage.
Klotho and Abdominal Aortic Calcifification: Results from NHANES 2013-2014
Authors: Ma Teng-Chi , Gao Feng , Zhou Jing 
Published: January 2022

Abstract
Objective:Background and purposes：Abdominal aortic calcification (AAC) has been considered as an excellent predictor of cardiovascular disease (CVD) events. Klotho is an important anti-aging substance, but the relationship between Klotho level and AAC has not been studied before.This research aimed to dig the association between S-Klotho and AAC in middle-aged and elderly people in the United States.Methods: Cross-sectional information were collected from the National Health and Nutrition examination Survey (NHANES) from 2013 to 2014, which surveyed 1364 males and females aged 40 and over. In order to evaluate the correlation between klotho and AAC, multivariate Logistic regression analysis was carried out. Fitting smooth curve and generalized additive model. We found that after adjusting several potential confounding factors, we found that there was a U-shaped dose-response relationship between klotho and AAC, and the inflection point of 1282.3pg/ml was calculated by two-stage linear regression model.ConclusionIn a typical sample of American adults, individuals with low or high levels of klotho have an increased risk of AAC. Although low klotho levels are widely considered harmful, these outcomes emphasize the demand for potential adverse health consequences of high klotho levels.
Principal Component Analysis As a Tool to Extract Sq Variation from the Geomagnetic Field Observations: Conditions of Applicability
Authors: Morozova Anna L. , Rebbah Rania 
Published: January 2022

Abstract
In this paper, we analyze the applicability of the principal component analysis (PCA) as a tool to extract the Sq variation of the geomagnetic field. We tested different geomagnetic field components and used data measured at different levels of the solar and geomagnetic activity and during different months. Geomagnetic field variations obtained with PCA were “classified” as SqPCA using two types of reference series: SqIQD series calculated using geomagnetically quiet days and simulations of the ionospheric field with models. The results for the X and Y and Z components are essentially different. The Sq variation is always filtered to the first PCA mode for the Y and Z components. Thus, PCA can automatically extract the Sq variation from the observations of the Y and Z components of the geomagnetic field. For the X component, the automatic extraction of the Sq variation is not possible, and a complimentary analysis, like a comparison to a reference series, is always needed. We tested two types of reference series: the mean SqIQD and the outputs of the CM5 and DIFI3 models. Our results show that both the data-based and model-based reference series can be used but the DIFI3 model performs better. We also recommend estimating the similarity of the series not with the correlation analysis but using metrics that account for possible local stretching/compressing of the compared series, for example, the dynamic time warping (DTW) distance.
Exploring Bimetallic Au-Ag Core Shell Nanoparticles Reduced Using Leaf Extract of Ocimum Tenuiflorum as A Potential Antibacterial and Nanocatalytic Agent
Authors: nayak sneha , Rao Chandrayan Vaman , Muttalik Srinivas 
Published: January 2022

Abstract
Biosynthesis of bimetallic Au-Ag core shell nanoparticle under ambient condition using Ocimum tenuiflorum (Krishna Tulsi) leaf extract is being reported for the first time. For the biosynthesized bimetallic core shell nanoparticles (OTAuAgNPs) visual and spectrophotometric analysis was performed. Development of a deep purple color suggested the creation of OTAuAgNPs. It was then validated by UV-Vis spectrophotometry within 4 hours of incubation showing a surface plasmon resonance peak at 560 nm. FESEM-EDAX, FT-IR, particle analyzer and XRD were the analytical techniques employed to characterize the biosynthesized OTAuAgNPs. Using a known antibiotic as a control, OTAuAgNPs had a substantial bacteriostatic effect against Gram +ve (Bacillus subtilis) and Gram -ve (E.coli, Pseudomonas aeruginosa) bacteria. The OTAuAgNPs showed good catalytic action for the adsorption of Coomassie brilliant blue R250 dye (CBB), confirmed by the reduction in absorbance maxima that is time dependant. A remarkable adsorption of CBB (94.79%) was attained within 120 min, and the results were best suited PSO and Elovich models with adsorption kinetic constant of 5.96E−04 g/mg.min and 37.81mg/g.min respectively. Further the toxicity studies of brilliant blue R250 dye and metabolite of CBB (post nano-remediated dye solution) was carried out on Vigna radiata (green gram) germination and growth. OTAuAgNPs as nano catalyst remediated water revealed that it was nontoxic. Thus an ecofriendly and cost effective approach for bimetallic nanoparticle synthesis could be further explored for removal of CBB from wastewater effluents.
Effects of Mineral Crystal Structure And Properties On The Macro-Mechanical Properties of Rocks
Authors: Yan Yongyan , Ding Wuxiu , Liu Guoji , Wang Hongyi 
Published: January 2022

Abstract
Rock is a nonhomogeneous material composed of one or more minerals. The structure and properties of internal mineral crystals have an impact on its macro-mechanical properties. Taking the Longmen Grottoes limestone as the research object, firstly, the mineral composition and macro-mechanical properties of the limestone are obtained, and through simulation and calculation of the crystal structure, chemical bond properties and elastic properties of minerals, this paper reveals how the mineral crystal structure and properties affect the macro-mechanical properties of the rock. Tests show that the main mineral components of the limestone in Longmen Grottoes are calcite and dolomite crystals. The uniaxial compression strength and elastic modulus of limestone with different calcite and dolomite contents are obviously different. From the study of crystal structure and chemical bond properties, it is learnt that the calcite and dolomite have similar crystal structures, but due to the difference of the chemical bond strength of Ca-O and Mg-O, the overall calcite crystal has a weaker chemical bond strength than the whole dolomite crystal. The First Principle simulation suggests a correlation between the overall crystal chemical bond strength and elastic modulus of the crystal. Therefore, studying the crystal structure and properties of minerals provides a significant research direction for revealing the mechanism of the macro-mechanical properties of rocks.
Diabetes Mellitus Affects Physical Activity in Patients with Moderate-To-Severe Knee Osteoarthritis
Authors: Fujita Remi , Ota Susumu , Yamamoto Yuri , Kataoka Akito , Warashina Hideki , Inoue Tomoe , Ozeki Shinya , Sugiura Hideshi 
Published: January 2022

Abstract
Background: Diabetes mellitus (DM) has been reported to be an independent risk factor for the development and severity of knee osteoarthritis (OA). Additionally, patients with DM are often obese or exercise insufficiently, and patients with knee OA and DM may have decreased physical activity at both light and moderate-to-vigorous intensity. To date, the effects of DM on physical activity in patients with knee OA have not been reported. We measured physical activity levels by intensity in patients with moderate-to-severe knee OA to confirm the effects of DM on physical activity levels in these patients.Methods: We evaluated 183 patients with moderate-to-severe knee OA (28 men, 155 women) diagnosed with knee OA by radiography and scheduled for total knee arthroplasty. We evaluated knee function (knee flexion/extension range-of-motion, knee-extension strength, knee pain), performance-based physical function (Timed Up-and-Go [TUG] test), and objectively measured physical activity. The effects of DM on physical activity were evaluated using hierarchical multiple regression analysis.Results: Fewer daily average step counts were significantly associated with DM (β = -0.200; p = 0.006) and longer TUG time (β = -0.196; p = 0.014). Shorter light-intensity physical activity (LPA) time was significantly associated with DM (β = -0.216; p = 0.004) and longer TUG time (β = -0.208; p = 0.011). Shorter moderate-to-vigorous-intensity physical activity (MVPA) time was significantly associated with lower contralateral knee-extension strength (β = 0.187; p = 0.032).Conclusions: DM, mobility, and balance ability affected step counts and LPA time, and contralateral knee-extension strength affected MVPA time in patients with moderate-to-severe knee OA. Our results imply that education on the benefits of exercise is important in patients with moderate-to-severe knee OA, especially those with DM, and there is a need for therapies to improve balance and strengthen the knee-extension muscles in this patient population, in order to increase their physical activity levels.
Immunoprofiling in Breast Cancer Microenvironment with Multiplexed Immunofluorescence
Authors: Yang Yalong , Li Chengxin , Dong Xingxing , Yuan Qianqian , Liu Jiuyang , Xu Gaoran , Hou Jinxuan , Gong Yan , Wu Gaosong 
Published: January 2022

Abstract
Background
The immunoprofiles in tumor microenvironment (TME) has established impacts on the tumorigenesis, metastasis, therapy sensitivity and prognosis in various solid tumors, including breast cancer. Regulation of local immune cell homeostasis is considered as a promising strategy for breast cancer therapy.
Aim
Comprehensively investigate the landscape of tumor-infiltrated immune cells in breast cancer and benign tissues, and provide novel evidence for potential immunotherapy strategies.
Method
A total of 140 pairs of breast cancer and benign tissues were collected and sectioned. The multiplexed immunofluorescence was applied to simultaneously analyze the immunoprofiles in breast cancer TME. Images were captured by AKOYA-Vectra 3 and analyzed with InForm 2.1 software.
Results
Comparing the general benign with malignant samples, the mean percentages of T cells (17.03% vs 14.85%, p=0.2329), B cells (6.406% vs 3.763%, p=0.0189), and macrophages (17.06% vs 27.1%, p=0.008) showed dramatic difference. In addition, we compared segmental areas, para-cancer with cancer tissues, different pathological and molecular types, and found that the main difference was the proportion of macrophages, especially the M2 subtype.
Conclusion
Macrophages and M2 subtype were the iconic differentiated infiltrating immune cells in breast cancer, especially related with the malignancy, clinic stages and tumorigenesis, which was the promising target in cancer therapy.
College Preparatory Schools and Critical Consciousness
Authors: Merth Robert Henry 
Published: January 2022

Abstract
Critical Consciousness (CC) is a construct that has been linked to political motivation and behaviors intended to circumvent oppression. Much of the work to date has examined CC for students of marginalized backgrounds and has paid little attention to how CC develops for privileged students. Additionally, while much of the CC literature has examined characteristics of schools that are linked with CC (i.e., school/classroom climate), no studies have inquired into the nature of the larger school setting as impacting CC-development. This study proposes that one school setting that may be related to both privilege (i.e., race and SES) and classroom climate are College Preparatory High Schools. Therefore, the current study contributes to the literature by examining the structural relations between privilege, College Preparatory High School enrollment, classroom climate, and two dimensions of CC: Critical Reflection (CR) and Critical Motivation (CM). Results indicate that controlling for race, SES is predictive of College Preparatory High School enrollment. Furthermore, College Preparatory High School enrollment is directly related to CM but not CR, and is indirectly related to both CR and CM through classroom climate. The implications of these findings are discussed.
Computational biomarker predicts lung ICI response via deep learning-driven hierarchical spatial modelling from H&amp;E
Authors: Xie Chensu , Vanderbilt Chad , Feng Chao , Ho David , Campanella Gabrielle , Egger Jacklynn , Plodkowski Andrew , Girshman Jeffrey , Sawan Peter , Arbour Kathryn , Hellmann Matthew , Fuchs Thomas 
Published: January 2022

Abstract
Determining which lung cancer patients are likely to respond to immune checkpoint inhibitors (ICI) remains a crucial challenge. Existing FDA-approved biomarkers lack sensitivity and specificity for identifying treatment candidates. To overcome this problem, we present a computational biomarker for predicting ICI response directly from routine H&E stained whole slide images of the initial biopsy. To achieve this, we developed an end-to-end deep learning system (EPL-GNN) that performs hierarchical spatial modeling on whole slide images to learn both spatial and morphological features from 2.1 billion cells and output a response score for each patient. The computational biomarker was trained and evaluated on the largest reported cohort of stage 4 lung cancer patients with ICI treatment response (N=583), resulting in an AUC of 0.69 and sensitivity of 91% on the independent test cohort, which compares favorably to PD-L1 immunohistochemistry (IHC) with an AUC of 0.68 and sensitivity of 57%, and tumor mutation burden (TMB) with an AUC of 0.62. The EPL-GNN model correctly identified 81% of the patients with a negative PD-L1 IHC result as responders. Visualizations of the hierarchical spatial model revealed potential cellular patterns that correspond to ICI treatment response. In addition to the increased sensitivity achieved by the EPL-GNN model, H&E-based Computational Biomarkers offer a faster, less expensive, more objective and reproducible alternative or adjunct to existing IHC or sequencing based biomarkers.