bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of ultrasound‐assisted extraction techniques on the valorization of agro‐based industrial organic waste – A review
Authors: Buvaneshwaran Malini , Radhakrishnan Mahendran , Natarajan Venkatachalapathy 
Published: March 2022

AbstractOne of the world's promising sectors is food processing. A huge amount of waste is generated during the handling and value addition of agricultural commodities. So researches focus on extracting valuable compounds from organic waste to increase the economical value. On the other hand, the amount of debris is also reduced, which helps sustainable development and carbon footprints. Extractable compounds can be used as an alternative to synthetic compounds in food applications. For this, Ultrasound‐Assisted Extraction (UAE) captures the researcher's attention because of its advantages like less solvent utilization, low‐temperature operation, and eco‐friendly end products. This review recapitulates the mechanism and the factors affecting the extraction and possibility of compounds extracted from waste. The green separation ultrasound‐aided technique has been proven to provide higher extractable compounds. Usage of water as a solvent further reduces environmental and economic problems. By considering all of these advantages, this article discusses the mechanism, elements affecting the extraction, and the effect of combination treatment on properties and the outcome of extraction. It presents the details about the application of the UAE in the valorization of waste compounds.Practical applicationFood processing is one of the most promising sectors globally; the agricultural organic waste created by this sector plays a significant part in waste generation. Extracting valuable active compounds from this waste can improve the utilization of natural compounds in other foods, help obtain extra income, and help reuse industrial waste. Ultrasound‐assisted extraction is a suitable technology for extracting valuable compounds from organic waste. Optimum process conditions must be identified, which vary based on process conditions and extractable material nature to obtain the maximum extraction.
Red cell folate status among a subset of Canadian children with Down Syndrome post‐fortification
Authors: Jory J. 
Published: March 2022

AbstractBackgroundTrisomy 21 or Down Syndrome (DS) is associated with altered methylation pathways. Children with DS may therefore represent a population subgroup with vulnerability to increased exposures to folic acid, which is involved in one‐carbon metabolism. Folic acid (FA) fortification of flour and maternal FA supplementation are intended to reduce neural tube defects related to folate deficiency. The interventions have been widely successful in Canada. Emerging evidence suggests that higher FA exposures may also have potential negative consequences, including implications for DNA methylation. This retrospective chart review provides insight on the red blood cell (RBC) folate status of a subset of Canadian children and infants with DS, post‐fortification.MethodsChildren with DS in two Canadian provinces were assessed in the community. Access to RBC folate testing was variable, limiting sample size to 39 (n = 27 for children ≤6 years; n = 12 for children 6–18 years). All children with DS and an RBC folate result were included. The use of FA‐containing supplements and formula was documented.ResultsAmong children 6–18 years, 100% had RBC folates >1000 nmol/L, 50% were >2000 nmol/L and 25% had levels above the upper laboratory reporting limit. Among the younger children (<6 years), 52% had RBC folates >2000 nmol and 2 children exceeded 3000 nmol/L. Among exclusively breast‐fed infants (<12 months), 100% had RBC folates >1000 nmol/L and 50% had levels >2000 nmol/L, suggestive of in‐utero or maternal exposures. RBC folate status among this subset of Canadian children with DS is higher than documented for the larger Canadian population, and higher than among US children with DS.ConclusionsYoung Canadian children with DS demonstrated high post‐fortification RBC folate status. RBC folate status was higher than reported for the larger Canadian population, and higher than for US children with Down Syndrome. Consumption of folic acid‐containing formula and/or supplements was relatively low among these Canadian children with DS, suggesting maternal FA supplements and/or FA‐fortified foods may be important etiological factors. A larger, prospective study is needed to validate these results, and to explore potential health implications among this vulnerable population.
Diagnosis of thrombotic microangiopathy in preeclampsia in the common marmoset (Callithrix jacchus) and treatment by cesarean section
Authors: Kim Jong‐Min , Kwak Jina , Kim Joo‐Il , Kim Donghun , Kang Byeong‐Cheol 
Published: March 2022

AbstractA pregnant common marmoset (Callithrix jacchus) showed tachypnea, hypothermia, and anorexia at close to the expected delivery date. Severe anemia and thrombocytopenia, schistocytes, and high levels of LDH and D‐dimer were observed. Three days after the onset of clinical signs, a cesarean section was conducted due to stillbirth. Marmoset immediately recovered after surgery, and the abnormal CBC and blood chemistry parameters before surgery returned to the normal ranges. Diagnosis of pregnancy‐associated thrombotic microangiopathy was made because removal of infant and placenta is curative. To the best of our knowledge, this is the first case report of thrombotic microangiopathy in a marmoset with preeclampsia.
Reducing information asymmetry and increasing health value co‐creation in a rural healthcare context
Authors: Dahl Andrew J. , Peltier James W. , Milne George R. 
Published: March 2022

AbstractDigital platforms offer emerging opportunities for disseminating information to improve decision‐making, motivate behavior changes, and enhance outcomes. However, consumer‐physician asymmetry and traditional service delivery principles create resource utilization conflicts that may hinder health value co‐creation efforts. We address how expert service contexts with high levels of information asymmetry may maximize value co‐creation by encouraging consumers' digital information usage to close the consumer‐physician information gap. Structural equation modeling of rural consumer surveys demonstrates the ancillary value created by supporting consumers' digital resource integration. The results identify how physicians may increase rural consumers' co‐creation of health outcomes by helping consumers utilize digital information to facilitate their activation in value co‐creation. However, physicians and consumers first need to share value perceptions of the digital inputs to maximize consumers' resource integration and co‐creation efforts.
Effect of omega‐3 fatty acids on premenstrual syndrome: A systematic review and meta‐analysis
Authors: Mohammadi Mohammad Mehdi , Dehghan Nayeri Nahid , Mashhadi Monireh , Varaei Shokoh 
Published: March 2022

AbstractIntroductionTo date, no definitive results have been reported on the effect of omega‐3 fatty acids on premenstrual syndrome (PMS). Therefore, this systematic review and meta‐analysis aimed to determine the effect of omega‐3 fatty acids on PMS.MethodsIn this systematic review and meta‐analysis, the databases were searched. In this regard, randomized clinical trials investigating the effect of omega‐3 fatty acids on PMS were included. The quality of the studies was assessed using the Cochrane Collaboration's Risk of Bias tool. Meta‐analysis was done based on random effects model and calculation of standardized mean difference (SMDs).ResultsThe results of meta‐analysis showed that omega‐3 fatty acids were efficient in reducing the severity of PMS in women (SMD = −0.968, 95% confidence interval [CI]: −1.471 to −0.464). In addition, the results showed that the studies were heterogeneous (I2 = 89.11%, p <0.001). Based on meta‐regression analysis, aging (β = −0.150, 95% CI −0.202 to −0.098, p <0.001) and increasing the duration of intervention (β = −0.579, 95% CI −0.781 to −0.378, p <0.001) had a significant effect on the severity of PMS. We also found that omega‐3 fatty acids could significantly reduce the somatic (SMD = −0.800, 95% CI: −1.126 to −0.474) and psychological (SMD = −0.373, 95% CI: −0.686 to −0.061) symptoms of PMS.ConclusionOmega‐3 fatty acids could reduce the severity of PMS. However, we should caution in the conclusion in affirming the beneficial effects of n‐3 PUFAs on PMS, since the heterogeneity is evident in the analysis. The efficacy of the treatment was enhanced by increase of the treatment duration.
The impact of the Coronavirus pandemic on New York City real estate: First evidence
Authors: Cohen Jeffrey P. , Friedt Felix L. , Lautier Jackson P. 
Published: March 2022

AbstractWe investigate whether pandemic‐induced contagion disamenities and income effects arising due to COVID‐related unemployment adversely affected real estate prices of one‐ or two‐family owner‐occupied properties across New York City (NYC). First, ordinary least squares hedonic results indicate that greater COVID case numbers are concentrated in neighborhoods with lower‐valued properties. Second, we use a repeat‐sales approach for the period 2003–2020, and we find that both the possibility of contagion and pandemic‐induced income effects adversely impacted home sale prices. Estimates suggest sale prices fell by roughly $60,000 or around 8% in response to both of the following: 1000 additional infections per 100,000 residents and a 10‐percentage point increase in unemployment in a given Modified Zip Code Tabulation Area (MODZCTA). These price effects were more pronounced during the second wave of infections. On the basis of cumulative MODZCTA infection rates through 2020, the estimated COVID‐19 price discount ranged from approximately 1% to 50% in the most affected neighborhoods, and averaged 14%. The contagion effect intensified in the more affluent, but less densely populated NYC neighborhoods, while the income effect was more pronounced in the most densely populated neighborhoods with more rental properties and greater population shares of foreign‐born residents. This disparity implies the pandemic may have been correlated with a wider gap in housing wealth in NYC between homeowners in lower‐priced and higher‐priced neighborhoods.
The Cultural Variance Model of Organizational Shame and its Implications on Health and Well‐Being1
Authors: Akutsu Satoshi , Krishnan Ramesh , Lee Jinju 
Published: March 2022

AbstractDrawing on various studies, we provide a holistic view incorporating different nested cultural contexts, organizational shame, and health outcomes. We introduce the concept of organizational shame and explain its two key domains: conformity and status/competition. Then, we comprehensively review prior studies on cultural approaches to shame and propose our cultural variance model of organizational shame. Our model illustrates an equilibrium, exhibiting dominant and stable patterns of shame domains formed by reinforcing relationships among three key nested contextual layers: individuals (workers), organizations (firms), and the labor market. We apply our model to discuss general and occupational implications and outline future research directions. Thus, we hope to conceptualize organizational shame within the dynamic contexts of organizations and cultures.
Caries in children with and without orofacial clefting: A systematic review and meta‐analysis
Authors: Grewcock Rebecca E. , Innes Nicola P. T. , Mossey Peter A. , Robertson Mark D. 
Published: March 2022

AbstractThis systematic review compared children's primary dentition caries experience for those with cleft lip and/or palate (CL/P) and without. Four databases were searched without date restriction for; cross‐sectional studies comparing caries experience for children with CL/P to those without. Screening, data extraction and risk assessment were carried out independently (in duplicate). Meta‐analyses used a random‐effects model. Twenty studies (21 reports) fitting the inclusion criteria comprised 4647 children in primary dentition from 12 countries. For dmft (n = 3016 children; 15 groups), CL/P mean = 3.2; standard deviation = 2.22 and no CL/P mean dmft = 2.5; sd 1.53. For dmfs (n = 1095 children; 6 groups), CL/P mean = 4; sd = 3.5 and no CL/P mean = 3; sd = 2.8. For % caries experience (n = 1094 children; 7 groups), CL/P mean = 65%; sd = 20.8 and no CL/P mean = 52%; sd = 28.1. Meta‐analysis showed higher caries experience in children with CL/P, standardised mean difference = 0.46; 95% CI = 0.15, 0.77. Studies' risk of bias was high (n = 7), medium (n−10) and low (n = 3). Children with CL/P had higher caries experience compared to those without CLP.
Patient‐activated anti‐tachycardia pacing in adult congenital heart disease
Authors: Carberry Thomas , Tsao Sabrina , Chaouki Ahmad Sami 
Published: March 2022

AbstractIntroductionIn adults with congenital heart disease, intra‐atrial reentrant tachycardia (IART) is a common arrhythmia that causes significant morbidity and mortality. One treatment option for IART is antitachycardia pacing. Atrial antitachycardia pacing algorithms deliver therapy for IART with ≥2:1 conduction, but most algorithms will not recognize IART with 1:1 conduction. Temporary Patient Activated Rx (TPARx) is Medtronic software that can be installed in antitachycardia pacemakers allowing patients to deliver therapies on demand for IART with 1:1 conduction.MethodsRetrospective chart review at a single institution of all patients who had TPARx installed into their pacemaker.ResultsFour adults with single ventricle congenital heart disease and IART underwent Fontan conversion, arrhythmia surgery, and placement of an epicardial dual‐chamber antitachycardia pacemaker. They had recurrent IART with a long cycle length and 1:1 conduction that failed to trigger antitachycardia pacing therapies. TPARx software was programmed into their pacemakers to allow recognition and treatment of IART with 1:1 conduction. Mean follow‐up duration after TPARx programming was 4.9 years. Each patient received at least one successful antitachycardia pacing therapy via TPARx – range 0.4–26 treated IART episodes per year. There were no atrial or ventricular arrhythmias induced with antitachycardia pacing. Two patients were able to discontinue anticoagulation after TPARx installation.ConclusionThis series demonstrates the use of TPARx software as part of a long‐term IART management strategy in select patients with IART who have failed more conventional therapies.
Impact of surgery and anesthesia during early brain development: A perfect storm
Authors: Keunen Kristin , Sperna Weiland Nicolaas H. , de Bakker Bernadette S. , de Vries Linda S. , Stevens Markus F. 
Published: March 2022

AbstractNeonatal surgery and concomitant anesthesia coincide with a timeframe of rapid brain development. The speed and complexity of early brain development superimposed on immature regulatory mechanisms that include incomplete cerebral autoregulation, insufficient free radical scavenging and an immature immune response puts the brain at risk. Brain injury may have long‐term consequences for multiple functional domains including cognition, learning skills, and behavior. Neurodevelopmental follow‐up studies have noted mild‐to‐moderate deficits in children who underwent major neonatal surgery and related anesthesia. The present review evaluates neonatal surgery against the background of neurobiological processes that unfold at a pace unparalleled by any other period of human brain development. First, a structured summary of early brain development is provided in order to establish theoretical groundwork. Next, literature on brain injury and neurodevelopmental outcome after neonatal surgery is discussed. Special attention is given to recent findings of structural brain damage reported after neonatal surgery. Notably, high‐quality imaging data acquired before surgery are currently lacking. Third, mechanisms of injury are interrogated taking the perspective of early brain development into account. We propose a novel disease model that constitutes a triad of inflammation, vascular immaturity, and neurotoxicity of prolonged exposure to anesthetic drugs. With each of these components exacerbating the other, this amalgam incites the perfect storm, resulting in brain injury. When examining the brain, it seems intuitive to distinguish between neonates (i.e., <60 postconceptional weeks) and more mature infants, multiple and/or prolonged anesthesia exposure and single, short surgery. This review culminates in an outline of anesthetic considerations and future directions that we believe will help move the field forward.
From problematisation to propositionality: Advancing southern urban infrastructure debates
Authors: Baptista Idalina , Cirolia Liza Rose 
Published: March 2022

AbstractIn this article, we explore the notion of propositionality to advance southern urban infrastructure debates towards more anticipatory forms of scholarship. By propositionality, we mean a research sensibility that engages, first and foremost, with propositions for infrastructure futures on their own terms. While scholarship on infrastructures in southern cities has contributed to very fruitful conceptual and methodological innovations, we argue that the current mode of problematisation does not lend itself to this propositional intent. Conceptually focused on deconstruction and critique and methodologically tied to heterogeneity at the community scale, this form of problematisation tends to produce localised knowledge about what is, but offers limited avenues for articulating what could be. After a brief introduction, the article provides a review of the main conceptual and methodological contributions and limitations of the dominant modes of researching southern urban infrastructure. We then explore a different mode of problematisation as the first step towards a propositional research sensibility, followed by an overview of a preliminary propositional skill set covering three aspects: mobilising technical knowledge more effectively; appreciating sectoral and scalar specificity; and addressing the challenges of normativity. Our arguments draw on literature from southern scholarship, science and technology studies (STS), and pragmatism, as well as empirical work conducted by ourselves and others. We conclude the article with a call for further reflection among southern urban scholars on ways to move us into a propositional space that better engages with the people and things we speak for and care about.
Insights into the geometry and evolution of the southern San Andreas fault from geophysical data, southern California
Authors: Langenheim V.E. , Fuis G.S. 
Published: March 2022

AbstractTwo new joint gravity-magnetic models in northern Coachella Valley provide additional evidence for a steep northeast dip of the Mission Creek strand of the southern San Andreas fault (southern California, USA). Gravity modeling indicates a steep northeast dip of the Banning fault in the upper 1–2 km in northern Coachella Valley. The Mission Creek strand and its continuation to the southeast (Coachella segment) coincide with the northeastern margin of a Cenozoic basin and are marked by prominent gravity and magnetic gradients that are consistent with these strands of the San Andreas fault having accommodated &gt;160 km of right-lateral and 1–5 km of vertical displacement. These anomalies are best fit by a moderate to steep northeast dip. Such a geometry is further supported by seismicity, reflectivity, geodesy, and boundary-element modeling. We explore the possibility that these fault strands forming the margin of Coachella Valley were originally near vertical and have rotated into their present orientation by underplating of a localized high-velocity, lower-crustal prong within the Peninsular Ranges batholith. Reconstructions of San Andreas fault offset suggest that this crystalline body was translated into the San Gorgonio Pass area at the time of major fault reorganization at 1.1–1.3 Ma.
Ocular geometry in adults born extremely, very and moderately preterm with and without retinopathy of prematurity: results from the Gutenberg Prematurity Eye Study
Authors: Fieß Achim , Nauen Hannah , Mildenberger Eva , Zepp Fred , Urschitz Michael S , Pfeiffer Norbert , Schuster Alexander Karl-Georg 
Published: March 2022

Background/aimsTo evaluate whether anterior segment anatomy and axial length are associated with prematurity and perinatal factors in adults.MethodsThe Gutenberg Prematurity Eye Study examined adults born preterm and term aged 18–52 years. All participants underwent a prospective ophthalmic examination (optical biometry via a LenStar 900, Haag-Streit) in Germany. The associations between gestational age (GA), birth weight (BW) and BW percentile, retinopathy of prematurity (ROP) occurrence, ROP treatment and other perinatal factors with the main outcome measures were evaluated by univariate and multivariable linear regression analyses. Main outcome measures were corneal radius, white-to-white distance, anterior chamber depth, lens thickness and axial length.ResultsThe study involved 861 eyes of 438 preterm and full-term individuals (aged 28.6±8.7 years, 245 females,). After adjustment for age and gender, a steeper corneal radius was associated with lower GA (B=0.02; p<0.001) and a lower BW percentile (B=0.003; p<0.001). A smaller white-to-white distance was linked to lower GA (B=0.02; p<0.001), a lower BW percentile (B=0.004; p<0.001) and postnatal ROP occurrence (B=−0.26; p<0.001). Decreased axial length was associated with lower GA at birth (B=0.05; p=0.002) and pre-eclampsia (B=−0.34; p=0.015). ROP-treated eyes had a shallower anterior chamber depth (B=−0.63; p=0.001) and increased lens thickness (B=0.64, p<0.001).ConclusionOur analyses in adults demonstrate that the corneal morphology is influenced by GA and BW percentile, while the anterior chamber depth and lens thickness are affected by ROP treatment, namely laser therapy and cryotherapy. The present study highlights that perinatal factors lead to lifelong sequelae of ocular shape.