bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trifunctional fluorescent manganese ferrite nanoparticles for hyperthermia therapy, cell probing and drug delivery
Authors: Mandal Goswami Madhuri , De Debarati 
Published: September 2022

Here we have reported a new protocol for drug delivery from hollow sphere manganese ferrite nanoparticles (HMF NPs). The crystalline structure of HMF NPs is obtained from XRD measurement and the morphological and elemental analysis are obtained from FESEM & TEM measurements. Here the HMF NPs are properly designed for delivery of dopamine (DA) as anticancer drug to cancer site. The DA polymerizes to a giant molecule polydopamine (PDA) inside hollow HMF in presence of TRIS buffer at pH (8.5) and a composite, HMF-PDA is formed. Being giant molecule polydopamine remain stable inside the hollow particles, but when these HMF-PDA come in contact of low pH i.e. pH 5 (cancer cells pH), free DA starts to be released. At hyperthermic temperature (45 °C) release enhances compare to physiological temperature (37 °C). The DA release studies are monitored by UV-visible absorption spectroscopy with progress of time at different temperatures and pH. It has been observed that HMF-PDA has fluorescent property whereas DA has no such effects. So, incorporation of PDA inside HMF and tagging of HMF-PDA with cancer cells can also be monitored by fluorescence imaging. Hence, we have successfully synthesized trifunctional HMF-PDA composite which can serve three purposes like cancer cell probing by fluorescence imaging, hyperthermia therapy and drug delivery by magnetic field and pH trigger method.
Triggerfrei zu Tisch!
Authors: März Henrike 
Published: September 2022

SummaryMS-Patienten sollten entzündungsfördernde Nahrungsfaktoren wie gesättigte Fettsäuren und leichtverdauliche Kohlenhydrate meiden. Nahrungsmittelunverträglichkeiten, zum Beispiel auf Gluten, sollten als Triggerfaktor ebenfalls abgeklärt werden. Erste Veröffentlichungen und Studien legen einen Zusammenhang zu MS nahe. Als entzündungshemmende Mikronährstoffe empfehlen sich in der Ernährung und zur Substitution unter anderem Vitamin D, Omega-3-Fettsäuren und Alpha-Liponsäure.
Spectral CT in Oncology
Authors: Sauerbeck Julia , Adam Gerhard , Meyer Mathias 
Published: September 2022

Background Spectral CT is gaining increasing clinical importance with multiple potential applications, including oncological imaging. Spectral CT-specific image data offers multiple advantages over conventional CT image data through various post-processing algorithms, which will be highlighted in the following review.
Methodology The purpose of this review article is to provide an overview of potential useful oncologic applications of spectral CT and to highlight specific spectral CT pitfalls. The technical background, clinical advantages of primary and follow-up spectral CT exams in oncology, and the application of appropriate spectral tools will be highlighted.
Results/Conclusions Spectral CT imaging offers multiple advantages over conventional CT imaging, particularly in the field of oncology. The combination of virtual native and low monoenergetic images leads to improved detection and characterization of oncologic lesions. Iodine-map images may provide a potential imaging biomarker for assessing treatment response.
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Citation Format
Resveratrol Protects BEAS-2B Cells against Erastin-Induced Ferroptosis through the Nrf2/Keap1 Pathway
Authors: Huang Wenhan , Yu Liuda , Cai Wanru , Ma Chunfang 
Published: September 2022

AbstractFerroptosis is a newly discovered type of cell death that is different from other types of cell death morphologically and biologically. It is considered to play an important role in many
pulmonary diseases. Currently, the regulatory roles of antioxidation in lung epithelial ferroptosis have not been fully explored. In this study, we show that resveratrol protected
erastin-induced ferroptosis in BEAS-2B cells. Erastin led to increased reactive oxygen species production and iron deposition in BEAS-2B cells, which could be rescued by resveratrol.
Furthermore, we observed that resveratrol led to modulating ferroptosis-associated gene glutathione peroxidase 4 expression and regulating glutathione in BEAS-2B cells. Resveratrol exerted
an antioxidant property in erastin-induced ferroptosis of BEAS-2B cells by activating the nuclear factor-erythroid 2-related factor 2/Kelch-like ECH-associated protein signaling pathway.
Finally, these findings demonstrate that resveratrol protects BEAS-2B from erastin-induced ferroptosis.
Effects of Chrysin on Oral Squamous Cell Carcinoma In Vitro
Authors: Puengsurin Duangchewan , Buranapraditkun Supranee , Leewansangtong Chayanee , Taechaaukarakul Nitchakarn , Songsivilai Proud , Surarit Rudee , Kitkumthorn Nakarin 
Published: September 2022

Abstract
Objective Chrysin is a hydroxylated flavonoid derived from “propolis or bee glue,” a natural product. Previous research on chrysin's biological functions, including anticancer activity, had been reported. However, chrysin's effect on oral squamous cell carcinoma (OSCC) is still scarce. This article aimed to test the cytotoxicity, antiproliferative, antimigration, anti-invasion, and apoptotic effects of purified chrysin in two OSCC cell lines, HSC4 and SCC25.
Materials and Methods The malignant phenotype was assessed using cell proliferation, wound healing, and transwell assays. Cell apoptosis was determined using flow cytometry. The positive control was OSCC cells treated with cisplatin, and the negative control was OSCC cells incubated with 0.1% dimethyl sulfoxide.
Results Chrysin at concentrations of 100 and 200 µM could inhibit OSCC cell proliferation, migration, and invasion, as well as enhance cell apoptosis, particularly in the early stages of apoptosis.
Conclusion In OSCC cell lines, chrysin has been demonstrated to be an effective antioncogenic agent. Additional research is required to confirm the results. Chrysin should be suggested as a possible alternative therapeutic application for OSCC.
Premolar Extraction Affects Mandibular Kinematics
Authors: Londoño Alejandra , Assis Miguel , Fornai Cinzia , Greven Markus 
Published: September 2022

Abstract
Objectives The practice of premolar extraction in orthodontics is controversial for its potential detrimental effects on the stomatognathic system. However, the ways in which premolar extraction affects mandibular function are still poorly understood. The purpose of this study was to assess the influence of premolar extraction on mandibular kinematics by evaluating axiographic tracings.
Materials and Methods Forty-five orthodontically treated patients with premolar teeth extraction were compared with 45 paired untreated controls, selected for the absence of malocclusions. Systematic three-dimensional axiographic recordings of the mandibular movements were performed for protrusive–retrusive movements and speech. The transversal deviations and length of the movements were recorded for both sides along with the rotation angle during speech.
Statistical Analysis Differences between the axiographic variables were analyzed via the permutation test and Wilcoxon rank-sum test. Linear regression was performed to test whether axiographic parameters were predictive of group affiliation. Dot plots were used to explore the distribution of each of the axiographic outcomes, and isometric principal component analysis to assess the differences between the cumulative effects of premolar extraction on jaw motion.
Results The mandibular lateral translation in protrusion–retrusion and speech, the amount of rotation as well as the length of mandibular movements during speech were significantly higher in the treated subjects than in the controls, while retral stability did not differ. The linear regression yielded significant results for the mandibular lateral translation in protrusion–retrusion. The isometric principal component analysis showed higher values of the axiographic variables for 11 out of 45 individuals in the study sample compared with the control group.
Conclusions Premolar extraction altered mandibular kinematics in at least 25% of the cases within our sample, and the transversal discrepancy between protrusive and retrusive tracings was even predictive of group affiliation. These results support the notion that the routine practice of premolar extraction as part of the orthodontic treatment should be discouraged. It is compelling to perform further studies to assess whether a disrupted kinematics of the mandible is associated to temporomandibular disorders.
The affective-discursive ‘pruning’ of neoliberal selves: introducing the notion of self-othering
Authors: Chowdhury Nilima 
Published: September 2022

AbstractIn this article, I develop the notion ofself-otheringdefined as the affective orchestration of different voices-of-the-self as an important self-constitutive practice of neoliberal subjectivity. I posit that neoliberal subjectification relies onotheringthose facets—skills, attributes, bodily properties—that do not conform to idealised notions of the self. By applying this conceptual lens to empirical material drawn from a qualitative research project on women’s identity negotiations, my aim is to show that affect, notably what feels right/wrong, plays a crucial role in aligning the body with neoliberal culture. The affective-discursive approach to analysing the dialogical self I propose is based on a problematisation of neoliberal logic and thus draws attention to the normativity of affect. The analysis of practices of self-othering lays bare how certain voices and ways of beingbecome unsayable.However, their presence in people’s self-constructions also suggests that they could be re-articulated to formulate a counter ideal.
Internal CSR and blue-collar workers’ attitudes and behaviors in China: a combination of a cross-sectional study and a field experiment
Authors: Lin-Hi Nick , Gao-Urhahn Xiaohan , Biemann Torsten , Koch-Bayram Irmela F. 
Published: September 2022

AbstractWhile a positive relationship between corporate social responsibility (CSR) and employee outcomes has been widely researched, most studies have been conducted in a Western context and for white-collar employees. Thus, little is known about Chinese blue-collar workers’ reactions to CSR. In two studies, we investigated the outcomes of internal CSR for blue-collar workers in the Chinese manufacturing industry. In the cross-sectional study, we found that perceived internal CSR is positively related to job satisfaction, trust in management, and perceived supervisory support. To further disentangle cause-and-effect relationships, we conducted a field experiment. The results show that internal CSR information increases performance quantity and lowers complaints, but also lowers performance quality and does not affect workers’ voice behavior. Our results further reveal that workers’ attitudes toward ethics and social responsibility are an important moderator which strengthens some of the hypothesized effects.
Coloring outside the lines? Imaginary reconstitution of security in Yemen through image transformations
Authors: Glybchenko Yelyzaveta 
Published: September 2022

AbstractInspired by new—forming in 2020—hopes for security and peace in Yemen, this essay explores the potential of digital image transformations for further empowerment of local actors already working for security and peace as well as bringing grassroots solutions into spotlight and into being. The essay analyzes the artistic transformation of a series of photographs submitted by a Yemeni citizen to the informal art-for-peace project Color Up Peace and turned into coloring pages for further engagement and transformation. Employing the utopia-informed methodology of Imaginary Reconstitution of Security, the analysis explores coloring pages as fields of opportunity to facilitate participation in peacework. Three questions guide this exploration: “what are visual images?,” “what do they do?” and “what is the normative basis of employing them?”—in relation to security as part of sustaining quality peace. The essay seeks to emphasize the importance of inclusive peace processes and arrangements, informed by everyday experiences of (in)security/(non)peace of regular citizens and allowing for a wide range of actors to participate. The included virtual exhibition of photographs, coloring pages and colored art further asks questions about participation, visuality and digitality of images and invites readers to make art and make peace within the project.
The transformation of participatory warfare: The role of narratives in connective mobilization in the Russia–Ukraine war
Authors: Asmolov Gregory 
Published: September 2022

AbstractThe participatory affordances of digital media allow a broad spectrum of new forms of participation in conflicts that go beyond the information domain (Boichak in Battlefront volunteers: mapping and deconstructing civilian resilience networks in Ukraine. #SMSociety’17, July 28–30, 2017). This article explores the factors that shape forms of digitally mediated participation in warfare. It highlights the association between narratives of statehood and forms of conflict-related mobilization of volunteers that rely on digital platforms. Rooted in an analysis of a dataset of digital platforms that mediated engagement in the warfare and 31 in-depth interviews with Ukrainian digital activists, it offers a model that helps to explain the diversity of modes of connective mobilization in the context of the war and the shifts in the role of digitally mediated conflict-related mobilization. The analysis does not aim to provide a linear model that explains the forms of mobilization but rather seeks to develop a framework that helps us understand the changes taking place in the scope and forms of participation in wars relying on digital platforms. The model suggests that the strengthening of narratives of statehood is associated with a transformation of conflict-related mobilization away from crowdsourcing and towards the emergence of organizations offering warfare-related outsourcing services and in some cases the incorporation of digital resources into state institutions (insourcing).
Properties and anticancer effects of plasma-activated medium stored at different temperatures
Authors: Fan Runze , Zhao Xinyi , Qi Miao , Zhang Huaiyan , Zhang Xinying , Zhang Jin , Li Qiaosong , Xu Dehui 
Published: September 2022

Plasma-activated solution (PAS) has attracted wide attention in cancer treatment because it can treat deep tumors and offer storability. The changes in reactive species and physicochemical properties of PAS during storage can affect its anticancer effect. In this study, the plasma-activated medium (PAM) was prepared by treating RPMI 1640 medium with afterglow gas generated by a custom-built air surface dielectric barrier discharge device. PAM was stored at four common temperature conditions (25 °C, 4 °C, −20 °C, and −80 °C) for 1 day, 4 days, and 7 days, and then, the physicochemical properties, reactive oxygen and nitrogen species (RONS), and the anti-cancer effect on A549 cells under different storage conditions were compared. The results showed that PAM exhibited different anticancer effects at different storage temperatures over a 7 day storage period. The anticancer ability of PAM under 80 °C storage remained stable after 7 days of storage and decreased at all other temperatures. These results were also verified by apoptosis results, and the differences were mainly related to the concentration of H2O2 and NO2−, and oxido reduction potential. Our results provided a theoretical basis for the storage of PAM and its application in anticancer therapy.
Cost-sharing reduction and health service utilisation, health-related lifestyles, and obesity: evidence from the Australian health concession card policy
Authors: Zhou Qin , Du Wei 
Published: September 2022

Background The Australian Health Concession Card (HCC) policy aims to improve access to affordable health services and medicines by providing reduced patient cost-sharing. This study explored the association between HCC holding and health service utilisation, as well as health-related lifestyles and obesity in Australian adults. Methods The Australian National Health Survey data were used to derive three sets of study outcomes. Multivariable generalised linear regression models were used to estimate the association between concessional status and study outcomes after controlling for socio-demographic factors. Results HCC holders, compared to their non-concessional counterparts, had more visits to GPs (1.01, 95% CI: 0.74–1.30), specialists (0.23, 95% CI: 0.02–0.44), outpatient clinics (0.19, 95% CI: 0.06–0.31), and had more hospital admissions (0.04, 95% CI: −0.05–0.91). There was no significant difference in visits to doctors and health professionals about mental health problems among HCC holders and their counterparts. Moreover, less HCC holders consumed alcohol on ≥3 days a week (OR: 0.75, 95% CI: 0.59–0.93) and had less of an alcohol risk that exceeded the 2001 alcohol guidelines (0.83, 95% CI: 0.69–0.99). Conclusions This study revealed evidence that reduced patient cost-sharing provided by HCC policy was positively correlated with more health service utilisation after adjusting for socio-demographic characteristics. Strategies to prioritise resources are necessary.
Tree use by koalas after timber harvesting in a mosaic landscape
Authors: Law Bradley , Slade Chris , Gonsalves Leroy , Brassil Traecey , Flanagan Cheyne , Kerr Isobel 
Published: September 2022

Context A better understanding of how individual animals use their habitat after disturbance can help optimise management practices for their conservation. Forestry is one such disturbance for koalas that operates under regulations based on best available information to minimise impacts. Aims This study aimed to investigate tree use by koalas in a mosaic of young, regenerating trees after timber harvest and mature trees in adjacent exclusion zones. Methods Tracking collars using very high frequency radio and Global Positioning System transmitters were used to track 10 koalas (five males, five females) across all seasons in three forests, 5–10 years after timber harvesting as regulated by practices current at that time. Tree use was compared to availability based on basal area in different parts of the forest. Key results We tracked koalas to 429 day-trees and 70 night-trees during this time. Males and females displayed little difference in tree use. Blackbutt Eucalyptus pilularis and turpentine Syncarpia glomulifera were the most commonly used species during the day, but blackbutt was ranked with the highest preference relative to tree availability. Tallowwood Eucalyptus microcorys was by far the most commonly used tree at night. Koalas used a broad range of tree sizes during the day and night, but most often used medium-sized trees, with preferences for a diameter of 30–60 cm (slightly smaller at night). Koalas used all topographic positions in the landscape, but more than half of the trees used were in lower topographic areas (gullies and lower slopes). Areas mapped as having previous heavy timber harvesting were the most used forest category, followed by riparian exclusion zones. Conclusions Our results demonstrate that koalas commonly used trees regenerating after harvest, although preferences for medium-sized trees and tallowwood as a night browse tree suggest current forestry regulations can be fine-tuned by retaining a greater proportion of these features. Implications Because most trees were used only once, our results support the view and current practice of retaining habitat patches, such as exclusion zones and wildlife clumps (triggered by a koala habitat model), to provide a mix of species and size classes for both food and shelter. A review of tree size and species retention is recommended.
Elastic properties and shape of the Piezo dome underlying its mechanosensory function
Authors: Haselwandter Christoph A. , Guo Yusong R. , Fu Ziao , MacKinnon Roderick 
Published: September 2022

We show in the companion paper that the free membrane shape of lipid bilayer vesicles containing the mechanosensitive ion channel Piezo can be predicted, with no free parameters, from membrane elasticity theory together with measurements of the protein geometry and vesicle size [C. A. Haselwandter, Y. R. Guo, Z. Fu, R. MacKinnon,
Proc. Natl. Acad. Sci. U.S.A.
, 10.1073/pnas.2208027119 (2022)]. Here we use these results to determine the force that the Piezo dome exerts on the free membrane and hence, that the free membrane exerts on the Piezo dome, for a range of vesicle sizes. From vesicle shape measurements alone, we thus obtain a force–distortion relationship for the Piezo dome, from which we deduce the Piezo dome’s intrinsic radius of curvature,

42
±
12

nm, and bending stiffness,

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±
2.1

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, in freestanding lipid bilayer membranes mimicking cell membranes. Applying these estimates to a spherical cap model of Piezo embedded in a lipid bilayer, we suggest that Piezo’s intrinsic curvature, surrounding membrane footprint, small stiffness, and large area are the key properties of Piezo that give rise to low-threshold, high-sensitivity mechanical gating.
Exploring genre variation and simplification in interpreted language from comparable and intermodal
perspectives
Authors: Xu Cui , Li Dechao 
Published: September 2022

Abstract
This article explores genre variation and simplification in interpreted language from both comparable (interpreted
vs. non-interpreted/non-mediated) and intermodal (interpreted vs. translated) perspectives. It draws on a newly built
unidirectional comparable and intermodal corpus named the LegCo+, which features legislative proceedings in the Legislative
Council of Hong Kong (including originals and their translations and interpretations from Cantonese to English), as well as
original plenary speeches delivered by native English speakers in the UK Parliament. It investigates the variation patterns of
four simplification features in three dimensions, namely, standardized type-token ratio (STTR) and list heads for lexical
diversity, lexical density for informativeness, and average sentence length for lexical sophistication. It aims to uncover the
effects of mediation and genre, as well as their interaction effects on linguistic variation. The results indicate that texts of
different mediation statuses and genre categories vary with respect to simplification patterns. From a comparable perspective,
interpretations rely on a narrower range of vocabulary than non-interpretations, but they are also more informative, and such
informativeness is dependent on genre categories. Intermodally speaking, interpretations exhibit consistent patterns of
simplification, indicating a strong modality (or mode of mediation) effect.
Anisotropic deformation of 4H-SiC wafers: insights from nanoindentation tests
Authors: Liu Xiaoshuang , Wang Rong , Zhang Junran , Lu Yunhao , Zhang Yiqiang , Yang Deren , Pi Xiaodong 
Published: September 2022

Abstract
In this work, the anisotropic deformation and anisotropic mechanical properties of 4H silicon carbide (4H-SiC) single crystal wafers are proposed by using nanoindentation. The C face of a 4H-SiC wafer has higher hardness and lower fracture toughness than those of the Si face. Because the deformation of 4H-SiC is assisted by the nucleation and slip of basal plane dislocations (BPDs), especially the slip of Si-core partial dislocations (PDs) of the BPDs, the nucleation and slip of the Si-core PDs in the Si face of 4H-SiC is easier than those in the C face, which releases the nanoindentation-induced stress and results in the decrease of the hardness and increase of the fracture toughness of the Si face of 4H-SiC wafers. Due to the hexagonal lattice of 4H-SiC, the hardness along

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, as a result of the enhanced glide of dislocations along the most closely-packed direction. The insights gained in this work are expected to shed light on the optimization of the mechanical processing of 4H-SiC wafers.