bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergent anisotropy in the Fulde–Ferrell–Larkin–Ovchinnikov state
Authors: Imajo Shusaku , Nomura Toshihiro , Kohama Yoshimitsu , Kindo Koichi 
Published: October 2022

AbstractExotic superconductivity is formed by unconventional electron pairing and exhibits various unique properties that cannot be explained by the basic theory. The Fulde–Ferrell–Larkin–Ovchinnikov (FFLO) state is known as an exotic superconducting state in that the electron pairs have a finite center-of-mass momentum leading to a spatially modulated pattern of superconductivity. The spatial modulation endows the FFLO state with emergent anisotropy. However, the anisotropy has never been experimentally verified despite numerous efforts over the years. Here, we report detection of anisotropic acoustic responses depending on the sound propagation direction appearing above the Pauli limit. This anisotropy reveals that the two-dimensional FFLO state has a center-of-mass momentum parallel to the nesting vector on the Fermi surface. The present findings will facilitate our understanding of not only superconductivity in solids but also exotic pairings of various particles.
Economic impacts of melting of the Antarctic Ice Sheet
Authors: Dietz Simon , Koninx Felix 
Published: October 2022

AbstractMelting of the Antarctic Ice Sheet (AIS) could contribute metres to global sea level rise (SLR) in the long run. We couple models of AIS melting due to rising temperatures, SLR, and economic impacts of SLR on coastlines worldwide. We report SLR projections close to the latest literature. Coastal impacts of AIS melting are very heterogeneous: they are large as a share of GDP in one to two dozen countries, primarily Small Island Developing States. Costs can be reduced dramatically by economically efficient, proactive coastal planning: relative to a no adaptation scenario, optimal adaptation reduces total costs by roughly an order of magnitude. AIS melting increases the social cost of carbon by an expected 7% on low to medium emissions scenarios and with moderate discounting. There is a tail risk of very large increases in the social cost of carbon, particularly on a high emissions scenario.
Nano-electromechanical spatial light modulator enabled by asymmetric resonant dielectric metasurfaces
Authors: Kwon Hyounghan , Zheng Tianzhe , Faraon Andrei 
Published: October 2022

AbstractSpatial light modulators (SLMs) play essential roles in various free-space optical technologies, offering spatio-temporal control of amplitude, phase, or polarization of light. Beyond conventional SLMs based on liquid crystals or microelectromechanical systems, active metasurfaces are considered as promising SLM platforms because they could simultaneously provide high-speed and small pixel size. However, the active metasurfaces reported so far have achieved either limited phase modulation or low efficiency. Here, we propose nano-electromechanically tunable asymmetric dielectric metasurfaces as a platform for reflective SLMs. Exploiting the strong asymmetric radiation of perturbed high-order Mie resonances, the metasurfaces experimentally achieve a phase-shift close to 290∘, over 50% reflectivity, and a wavelength-scale pixel size. Electrical control of diffraction patterns is also achieved by displacing the Mie resonators using nano-electro-mechanical forces. This work paves the ways for future exploration of the asymmetric metasurfaces and for their application to the next-generation SLMs.
Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP
Authors: Schumacher Maria A. , Wörmann Mirka E. , Henderson Max , Salinas Raul , Latoscha Andreas , Al-Bassam Mahmoud M. , Singh Kumar Siddharth , Barclay Elaine , Gunka Katrin , Tschowri Natalia 
Published: October 2022

AbstractStreptomyces are our principal source of antibiotics, which they generate concomitant with a complex developmental transition from vegetative hyphae to spores. c-di-GMP acts as a linchpin in this transition by binding and regulating the key developmental regulators, BldD and WhiG. Here we show that c-di-GMP also binds the glycogen-debranching-enzyme, GlgX, uncovering a direct link between c-di-GMP and glycogen metabolism in bacteria. Further, we show c-di-GMP binding is required for GlgX activity. We describe structures of apo and c-di-GMP-bound GlgX and, strikingly, their comparison shows c-di-GMP induces long-range conformational changes, reorganizing the catalytic pocket to an active state. Glycogen is an important glucose storage compound that enables animals to cope with starvation and stress. Our in vivo studies reveal the important biological role of GlgX in Streptomyces glucose availability control. Overall, we identify a function of c-di-GMP in controlling energy storage metabolism in bacteria, which is widespread in Actinobacteria.
Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape
Authors: Singleton S. Parker , Luppi Andrea I. , Carhart-Harris Robin L. , Cruzat Josephine , Roseman Leor , Nutt David J. , Deco Gustavo , Kringelbach Morten L. , Stamatakis Emmanuel A. , Kuceyeski Amy 
Published: October 2022

AbstractPsychedelics including lysergic acid diethylamide (LSD) and psilocybin temporarily alter subjective experience through their neurochemical effects. Serotonin 2a (5-HT2a) receptor agonism by these compounds is associated with more diverse (entropic) brain activity. We postulate that this increase in entropy may arise in part from a flattening of the brain’s control energy landscape, which can be observed using network control theory to quantify the energy required to transition between recurrent brain states. Using brain states derived from existing functional magnetic resonance imaging (fMRI) datasets, we show that LSD and psilocybin reduce control energy required for brain state transitions compared to placebo. Furthermore, across individuals, reduction in control energy correlates with more frequent state transitions and increased entropy of brain state dynamics. Through network control analysis that incorporates the spatial distribution of 5-HT2a receptors (obtained from publicly available positron emission tomography (PET) data under non-drug conditions), we demonstrate an association between the 5-HT2a receptor and reduced control energy. Our findings provide evidence that 5-HT2a receptor agonist compounds allow for more facile state transitions and more temporally diverse brain activity. More broadly, we demonstrate that receptor-informed network control theory can model the impact of neuropharmacological manipulation on brain activity dynamics.
Submarine melting of glaciers in Greenland amplified by atmospheric warming
Authors: Slater D. A. , Straneo F. 
Published: October 2022

AbstractRapid ice loss from the Greenland ice sheet since 1992 is due in equal parts to increased surface melting and accelerated ice flow. The latter is conventionally attributed to ocean warming, which has enhanced submarine melting of the fronts of Greenland’s marine-terminating glaciers. Yet, through the release of ice sheet surface meltwater into the ocean, which excites near-glacier ocean circulation and in turn the transfer of heat from ocean to ice, a warming atmosphere can increase submarine melting even in the absence of ocean warming. The relative importance of atmospheric and oceanic warming in driving increased submarine melting has, however, not been quantified. Here, we reconstruct the rate of submarine melting at Greenland’s marine-terminating glaciers from 1979 to 2018 and estimate the resulting dynamic mass loss. We show that in south Greenland, variability in submarine melting was indeed governed by the ocean, but, in contrast, the atmosphere dominated in the northwest. At the ice sheet scale, the atmosphere plays a first-order role in controlling submarine melting and the subsequent dynamic mass loss. Our results challenge the attribution of dynamic mass loss to ocean warming alone and show that a warming atmosphere has amplified the impact of the ocean on the Greenland ice sheet.
Synovial fluid mesenchymal progenitor cells from patients with juvenile idiopathic arthritis demonstrate limited self-renewal and chondrogenesis
Authors: Krawetz Roman J. , Affan Asmaa , Leonard Catherine , Veeramreddy Dwaraka Natha , Fichadiya Akash , Martin Liam , Schmeling Heinrike 
Published: October 2022

AbstractJuvenile idiopathic arthritis (JIA) is a heterogeneous group of inflammatory diseases affecting joints with a prevalence of one in a thousand children. There is a growing body of literature examining the use of mesenchymal stem/progenitor cells (MPCs) for the treatment of adult and childhood arthritis, however, we still lack a clear understanding of how these MPC populations are impacted by arthritic disease states and how this could influence treatment efficacy. In the current study we examined the immunophenotyping, self-renewal ability and chondrogenic capacity (in vitro and in vivo) of synovial derived MPCs from normal, JIA and RA joints. Synovial MPCs from JIA patients demonstrated reduced self-renewal ability and chondrogenic differentiation capacity. Furthermore, they did not induce cartilage regeneration when xenotransplanted in a mouse cartilage injury model. Synovial MPCs from JIA patients are functionally compromised compared to MPCs from normal and/or RA joints. The molecular mechanisms behind this loss of function remain elusive. Further study is required to see if these cells can be re-functionalized and used in cell therapy strategies for these JIA patients, or if allogenic approaches should be considered.
A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma
Authors: Warrick Joshua I. , Knowles Margaret A. , Hurst Carolyn D. , Shuman Lauren , Raman Jay D. , Walter Vonn , Putt Jeffrey , Dyrskjøt Lars , Groeneveld Clarice , Castro Mauro A. A. , Robertson A. Gordon , DeGraff David J. 
Published: October 2022

AbstractHuman cancers display a restricted set of expression profiles, despite diverse mutational drivers. This has led to the hypothesis that select sets of transcription factors act on similar target genes as an integrated network, buffering a tumor’s transcriptional state. Noninvasive papillary urothelial carcinoma (NIPUC) with higher cell cycle activity has higher risk of recurrence and progression. In this paper, we describe a transcriptional network of cell cycle dysregulation in NIPUC, which was delineated using the ARACNe algorithm applied to expression data from a new cohort (n = 81, RNA sequencing), and two previously published cohorts. The transcriptional network comprised 121 transcription factors, including the pluripotency factors SOX2 and SALL4, the sex hormone binding receptors ESR1 and PGR, and multiple homeobox factors. Of these 121 transcription factors, 65 and 56 were more active in tumors with greater and less cell cycle activity, respectively. When clustered by activity of these transcription factors, tumors divided into High Cell Cycle versus Low Cell Cycle groups. Tumors in the High Cell Cycle group demonstrated greater mutational burden and copy number instability. A putative mutational driver of cell cycle dysregulation, such as homozygous loss of CDKN2A, was found in only 50% of High Cell Cycle NIPUC, suggesting a prominent role of transcription factor activity in driving cell cycle dysregulation. Activity of the 121 transcription factors strongly associated with expression of EZH2 and other members of the PRC2 complex, suggesting regulation by this complex influences expression of the transcription factors in this network. Activity of transcription factors in this network also associated with signatures of pluripotency and epithelial-to-mesenchymal transition (EMT), suggesting they play a role in driving evolution to invasive carcinoma. Consistent with this, these transcription factors differed in activity between NIPUC and invasive urothelial carcinoma.
White matter connectivity in brain networks supporting social and affective processing predicts real-world social network characteristics
Authors: Hyon Ryan , Chavez Robert S. , Chwe John Andrew H. , Wheatley Thalia , Kleinbaum Adam M. , Parkinson Carolyn 
Published: October 2022

AbstractHuman behavior is embedded in social networks. Certain characteristics of the positions that people occupy within these networks appear to be stable within individuals. Such traits likely stem in part from individual differences in how people tend to think and behave, which may be driven by individual differences in the neuroanatomy supporting socio-affective processing. To investigate this possibility, we reconstructed the full social networks of three graduate student cohorts (N = 275;N = 279;N = 285), a subset of whom (N = 112) underwent diffusion magnetic resonance imaging. Although no single tract in isolation appears to be necessary or sufficient to predict social network characteristics, distributed patterns of white matter microstructural integrity in brain networks supporting social and affective processing predict eigenvector centrality (how well-connected someone is to well-connected others) and brokerage (how much one connects otherwise unconnected others). Thus, where individuals sit in their real-world social networks is reflected in their structural brain networks. More broadly, these results suggest that the application of data-driven methods to neuroimaging data can be a promising approach to investigate how brains shape and are shaped by individuals’ positions in their real-world social networks.
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma
Authors: Chen Qi-tao , Zhang Zhi-yuan , Huang Qiao-ling , Chen Hang-zi , Hong Wen-bin , Lin Tianwei , Zhao Wen-xiu , Wang Xiao-min , Ju Cui-yu , Wu Liu-zheng , Huang Ya-ying , Hou Pei-pei , Wang Wei-jia , Zhou Dawang , Deng Xianming , Wu Qiao 
Published: October 2022

AbstractExtracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which facilitates the secretion of HK1 via large extracellular vesicles in a TSG101-dependent manner. The large extracellular vesicle HK1 is hijacked by hepatocellular carcinoma (HCC) cells, leading to accelerated glycolysis and HCC progression. In HSCs, the nuclear receptor Nur77 transcriptionally activates the expression of depalmitoylase ABHD17B to inhibit HK1 palmitoylation, consequently attenuating HK1 release. However, TGF-β-activated Akt functionally represses Nur77 by inducing Nur77 phosphorylation and degradation. We identify the small molecule PDNPA that binds Nur77 to generate steric hindrance to block Akt targeting, thereby disrupting Akt-mediated Nur77 degradation and preserving Nur77 inhibition of HK1 release. Together, this study demonstrates an overlooked function of HK1 in HCC upon its release from HSCs and highlights PDNPA as a candidate compound for inhibiting HCC progression.
Unravelling the interplay of ecological processes structuring the bacterial rare biosphere
Authors: Jia Xiu , Dini-Andreote Francisco , Salles Joana Falcão 
Published: October 2022

Abstract
Most ecological communities harbor many rare species (i.e., the rare biosphere), however, relatively little is known about how distinct ecological processes structure their existence. Here, we used spatiotemporal data on soil bacterial communities along a natural ecosystem gradient to model the relative influences of assembly processes structuring the rare and common biospheres. We found a greater influence of homogeneous selection (i.e., imposed by spatiotemporally constant variables) mediating the assembly of the rare biosphere, whereas the common biosphere was mostly governed by variable selection (i.e., imposed by spatial and/or temporal fluctuating variables). By partitioning the different types of rarity, we found homogeneous selection to explain the prevalence of permanently rare taxa, thus suggesting their persistence at low abundances to be restrained by physiological traits. Conversely, the dynamics of conditionally rare taxa were mostly structured by variable selection, which aligns with the ability of these taxa to switch between rarity and commonness as responses to environmental spatiotemporal variations. Taken together, our study contributes to the establishment of a link between conceptual and empirical developments in the ecology of the soil microbial rare biosphere. Besides, this study provides a framework to better understand, model, and predict the existence and dynamics of microbial rare biospheres across divergent systems and scales.
Size- and shape-adaptable mixed-alkoxide-aggregates: encapsulation of tetrafluoroborate and butadiynediide
Authors: Cebi Erkam , Streit Sarah Marie , Klett Jan 
Published: October 2022

Treatment of silyl compounds with excess sodium tert-butoxide results in encapsulation of the released anion. While the BF4− anion just fits in a spherical sodium alkoxide hull, the butadiyenediide dianion pierces its hull resulting in dimerisation.
Red emitting fluorescent carbon nanoparticles to track spatio-temporal dynamics of endocytic pathways in model neuroblastoma neurons
Authors: Hivare Pravin , Singh Udisha , Mujmer Kratika , Gupta Sharad , Bhatia Dhiraj 
Published: October 2022

Schematic diagram showing the fluorescent carbon nanoparticle synthesis and its biological applications in SH-SY5Y cells and differentiated neurons. Carbon nanoparticles enter mostly via a clathrin-mediated endocytic pathway in SH-SY5Y cells and differentiated neurons.
The star formation history of Upper Scorpius and Ophiuchus
Authors: Miret-Roig N. , Galli P. A. B. , Olivares J. , Bouy H. , Alves J. , Barrado D. 
Published: October 2022

Context. Understanding how star formation begins and propagates through molecular clouds is a fundamental but still open question. One major difficulty in addressing this question is the lack of precise 3D kinematics and age information for young stellar populations. Thanks to astrometry provided by Gaia, large spectroscopic surveys, and improved age-dating methods, this picture is changing.
Aims. We aim to study spatial and kinematic substructures of the region encompassed by the Upper Scorpius and Ophiuchus star forming regions. We want to determine dynamical traceback ages and study the star formation history (SFH) of the complex.
Methods. We combined our spectroscopic observations with spectra in public archives and large radial velocity surveys to obtain a precise radial velocity sample to complement the Gaia astrometry. We used a Gaussian Mixture Model to identify different kinematic structures in the 6D space of positions and velocities. We applied an orbital traceback analysis to estimate a dynamical traceback age for each group and determine the place where it was born.
Results. We identified seven different groups in this region. Four groups (ν Sco, β Sco, σ Sco and δ Sco) are part of Upper Scorpius, two groups (ρ Oph and α Sco) are in Ophiuchus, and another group (π Sco) is a nearby young population. We found an age gradient from the ρ Oph group (the youngest) to the δ Sco group (≲5 Myr), showing that star formation has been a sequential process for the past 5 Myr. Our traceback analysis shows that Upper Scorpius and ρ Oph groups share a common origin. The closer group of π Sco is probably older, and the traceback analysis suggests that this group and the α Sco group have different origins, likely related to other associations in the Sco-Cen complex.
Conclusions. Our study shows that this region has a complex SFH that goes beyond the current formation scenario, and is likely a result of stellar feedback from massive stars, supernova explosions, and dynamic interactions between stellar groups and the molecular gas. In particular, we speculate that photoionisation from the massive δ Sco star could have triggered star formation first in the β Sco group and then in the ν Sco group. The perturbations of stellar orbits due to stellar feedback and dynamical interactions could also be responsible for the 1–3 Myr difference that we found between dynamical traceback ages and isochronal ages.
Multimorbidity in a 35-Year-Old Female Patient Treated with Homeopathy: A Case Report
Authors: Mallangi Jayasubhashini , Chaudhuri Jyotika , Varanasi Roja , Oberai Praveen 
Published: October 2022

Abstract
Background Multimorbidity, a prevailing trend in the primary care population of all ages, is a challenge for health care systems that are largely configured for single disease management. Homeopathy has shown competence in the management of chronic diseases, whether they occur as a single ailment or as a multimorbidity.
Case History A 35-year-old female patient presenting with hemorrhoids, low back pain, hypothyroidism, fibroadenosis breasts (bilateral), and fibroid uterus was given homeopathic treatment for 33 months at Nandigama AYUSH Lifestyle Disorders Clinic, Andhra Pradesh. She was prescribed the homeopathic medicines Lachesis mutus and Thyroidinum at different time intervals based on the totality of symptoms.
Results Following treatment, a reduction in the size of the uterine fibroid and complete regression of breast lumps in ultrasonography were noted. The modified Naranjo criteria total score was 10 out of 13. Further, significant improvement in symptoms and laboratory parameters, such as triiodothyronine (T3), tetra-iodothyronine (T4), and thyroid-stimulating hormone (TSH), indicated that a well-chosen homeopathic medicine may be beneficial in managing multimorbidity.
Conclusion This case study reveals a positive role of homeopathic treatment in multimorbidity. More case studies and well-designed controlled research should be used to further investigate homeopathic intervention in multimorbidity.
In Vitro Cytotoxicity and Mineralization Potential of an Endodontic Bioceramic Material
Authors: Sheela Soumya , Nassar Mohannad , AlGhalban Fatma M. , Gorduysus Mehmet O. 
Published: October 2022

Abstract
Objective The interest in bioceramic materials has been steadily growing for different applications in endodontics. With the continued introduction of new bioceramic-based materials into the market, it is of great importance to assess the biocompatibility before providing recommendations on their clinical use. This study evaluated the in vitro cytotoxicity and mineralization potential of two consistencies of unset premixed bioceramic material (TotalFill BC RRM putty and TotalFill BC sealer) compared with an epoxy resin-based sealer (AH Plus) on osteoblast cells.
Materials and Methods Overall, 100% extracts were obtained by weighing 0.1 g of each material in 1 mL of cell culture media. Primary human osteoblast (HOB) cells (n = 4) were treated with different concentrations (100, 50, 25, 12.50, and 6.25%) of each extract. XTT assay and Alizarin Red S staining were used to evaluate the cytotoxic effect and the biomineralization potential, respectively.
Statistical Analysis Data were analyzed by one-way analysis of variance followed by Tukey's post hoc tests.
Results The cytotoxicity assay after 24 h treatment showed that all materials at high concentrations of the extract (100 and 50%) were toxic to HOB (p < 0.001). On the contrary to TotalFill BC RRM Putty, AH Plus and TotalFill BC sealer were toxic at 25% concentration. However, at 12.5% concentration and lower, all materials were nontoxic. The mineralization potential analyzed after 7 and 14 days showed that TotalFill BC material–treated cells could deposit mineralized nodules in the normal and osteogenic medium unlike AH plus-treated cells.
Conclusion At low concentrations, TotalFill BC materials showed higher biocompatibility to HOB cells than AH Plus, enhanced the viability of the cells, maintained their typical morphology, and induced the formation of mineralized nodules. Despite the encouraging data, clinical trials are needed to identify the effect of this material on the long-term outcome of endodontic treatment.