bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Technique for Intraradicular Rehabilitation Using Mta and Light Transmitting Fibre Post: A Case Report
Authors: Chauhan Dr. Vatsal , Narang Anu , Singh Santosh kumar , Sharma Anjali 
Published: September 2022

Restoring an endodontically treated teeth may become problematic due to inadequate sound radicular structure. In such cases where apices are flared ,its even more challenging to debride the canal and control the obturating material within the canal. Regarding rehabilitating the radicular structure; cast post have been used since older times. But it resulted in catastrophic root fracture with reduced remaining dentinal thickness, shadowing and graying of root and discoloration at the tooth’s gingival margin. Hence This case report presents a clinical case where intraradicular rehabilitation is done using MTA and light transimitting fibre post .
Non-surgical Management of Skeletal Class III and Dental Class I Malocclusion -A Case Report
Authors: Priya Parul , Tanisha Singh  , Sumit Tomar  , Manish Goyal  , Mukesh Kumar  , Navneet Kunj  
Published: September 2022

ABSTRACT
This case report discusses the nonsurgical, nonextraction therapy of a female patient, aged 21years, with a skeletal Class III malocclusion, reverse overjet and presence of retained maxillary canine bilaterally. Reverse overjet was corrected by protrusion of maxillary teeth, which contributed to alignment and leveling of teeth. Following fixed orthodontic treatment, there was considerable enhancement in patient's smile as well as an increase in the patient's confidence and quality of life. The profile changes and treatment results were demonstrated with proper case selection and good patient cooperation with fixed appliance therapy. At the end of treatment the patient was extremely satisfied with the results.
Determination of biometric relationship between cranial circumference and the mesio distal dimensions of maxillary anterior teeth.
Authors: Kumari Sommya , KUMAR MUKESH , Pankaj Kumar  , Pragyan Das  , Shrimali Sumi  
Published: September 2022

ABSTRACT:
Objective: To evaluate biometric relationship between cranial circumference and the mesio distal dimensions of maxillary anterior teeth.
Methods: A randomly selected 150 subjects comprising equal number of males and females were evaluated for the craniometric and odontometric measurements were obtained with the help of a non-stretchable measuring tape and a sliding digital stainless-steel Vernier caliper. The tests used were Oneway ANOVA, correlation and linear regression analysis. The confidence level for this study was 95% and the p-value for statistical significance was set at less than 0.05.
Result: Males had a greater mean head circumference compared to females. showed a highly statistically significant Gender Dimorphism for cranial circumference. Also Males had a statistically significantly greater mean Combined Mesio Distal Width of Maxillary Anterior Teeth compared to females. The Pearson test showed weak negative correlation for males, and weak positive correlation for females and combined data.
Conclusion: The study result could be used as a base data for further studies with larger sample size.
Key words: Edentulous, Esthetics, Denture, Craniometry , Odontometry.
Awareness of Periodontal Disease And its Influence on Systemic Health: A Survey Among Medical Professionals in State of Rajasthan (bikaner Subdivision).”
Authors: GARG DR KAMAL 
Published: September 2022

Background: Since past few decades, it is established that periodontitis has powerful influence on various systemic conditions. To maintain general health among the medical professionals this bidirectional link between periodontal and systemic health should be acquainted.
Aims: To evaluate knowledge, awareness and orientation of medical professionals towards periodontal diseases and its influence on systemic health in state of Rajasthan (Bikaner sub division). To aware medical professionals for overall improved health care delivery system and motivate referrals to periodontists in systemically ill patients.
Method and Material: Prepared questionnaire data was gathered from 503 medical professionals of various medical institutions in state of Rajasthan (Bikaner sub division). Study spanned from June 2019 to August 2019. Data was tabulated in Microsoft Excel sheet and subjected to statistical analysis. Mean and standard deviations of measurements per group were calculated, and differences between two groups were determined using chi square test.
Results: Majority of participants had basic knowledge regarding periodontal diseases but clinical orientation and practice behavior were very limited. Most of them were aware regarding systemic effects of periodontal diseases like chronic heart diseases, diabetes but were unaware of likely effects of periodontal diseases on conditions such as adverse pregnancy outcomes (PTLBW, PROM, and Preeclampsia) and hospital acquired pneumonia.
Conclusion: Medical practitioners had insufficient knowledge and limited clinical orientation about periodontal diseases and its potential influence on systemic conditions. This emphasizes need for periodontal education in medical field.
Evaluvation of The Transverse Strength of Acrylic Denture Base Resins Repaired by Different Materials: An Invitro Study
Authors: Mundra Rohit , Porwal Dr surbhi 
Published: September 2022

AIMS: The aim of the study undertaken was to evaluate an effective method of denture repair, which will have considerable transverse and impact strength, quick to repair and can be effectively utilized by the general practitioner.
OBJECTIVES: 1) To evaluate the transverse strength of denture base resin repaired by different methods having 45° joint surface contours and compare it with denture base acrylic resin repaired by conventional methods.
2) To find out the best material for repair.
MATERIAL AND METHODS: For the purpose of this study, Heat cure resin (DPI), Autopolymerising resins (DPI) and Glass Fibers (interling), were taken from the market. The unrepaired conventional heat cure denture base resin (DPI heat cure) plates were used as control group. .
RESULTS:
1) The mean transverse and impact strength of all the samples repaired by various methods showed significantly lower strength than control group (heat cure unrepaired samples used as control for transverse strength) 103.33MPa, although statistically significant.
2) Specimens repaired by self cure resin with glass fibers having 450 bevel joint showed the highest transverse strength.
Age estimation by Willem’s method in age group of 6-12 year old children- a cross sectional study
Authors: Sahu Pitambra , Prabakaran Gayathri , Saxena Ashish , Parihar Ajay , Verma Neha , Chauhan Shikhar pratap 
Published: September 2022

Aim and objective :
This article focuses on Willems method of age estimation in age group of 6-12 year old children.

Material and methods:
25 orthopantomagram of children aged 6-12 year old children were collected from the patients visiting the Department of Pediatric and Preventive dentistry, government college of Dentistry, Indore.

Results:
Comparison of the Dental age (DA) using the Willems method, the CA and differences between Dental age and Chronological age (DA and CA) of both gender and age groups .The independent samples t‑test results showcased that the mean CA was 1.81 for males and 2.22 for females and the mean DA was 1.97 for males and 1.64 for females. This mean dictated an under aging of the entire sample as by about 0.58 years. Independent t‑test showed that these differences were statistically not significant as the p value is less (P > 0.05).
Pearson’s correlation test showed r value for overall data as 0.86, for male as 0.87 and for female as 0.88. The p value was statistically significant in overall data and male (<0.001).

Conclusion:

It is important to realize that no age estimation method will accurately determine the exact age for every individual since development naturally varies between individuals. One of the most important aspect of DA estimation is to remember that one should not restrict to only one age estimation technique, but to apply different techniques available and perform repetitive measurements and calculations. Also the sample size should be larger as compared to the present study, as well as equal numbers of both male and female should be studied.
Denture Satisfaction – The Most Wanted Key to Successful Complete Denture Therapy.
Authors: Kumari Sommya , Mukesh kumar  , Pankaj Kumar  , Pragyan Das  , Shrimali Sumi  
Published: September 2022

Abstract:
Background: The dilemma of patient satisfaction vs. non-satisfaction with dentures is another never-ending debate in dentistry. The fabrication of optimal dentures is possible with appropriate prosthetic laboratory techniques along with patients’ anatomic and physiologic requirements assessed by a dentist.
Aim : The purpose of this study was to evaluate the patient’s priority and mean satisfaction scores of the patient and dentist during complete denture therapy.
Material and methods: After selecting the subjects based on decided inclusion and exclusion criteria, the patients were asked to fill the proforma with VAS. The proforma contained a questionnaire. The patients rated their dentures using a scale ranging from 1-5.
Results: According to the patient’s priority the majority of the patients preferred mastication. The highest mean dentist satisfaction score was concerned with the extension of a denture. There was no statistically significant difference with age and gender for mean denture assessment, aesthetic, phonetics, mastication and comfort satisfaction score. However, the employed patients have aesthetic, phonetics and mastication satisfaction score higher than unemployed patients and the relationship was statistically significant.
Conclusion: Majority of the patients was concerned with better chewing function with their dentures. Age and gender do not affect patient satisfaction. However, employed patients were less satisfied with their dentures as compare to unemployed patients. In addition, patients who were educated had better phonetics with their dentures as compare to uneducated patients. Strong dentist-patient communication is necessary to be able to satisfy a patient.
Keywords: Complete denture, Satisfaction, Patient communication
Intracranial meningiomas: clinical, intrascopic and pathomorphological causes of recurrence (literature review)
Authors: Kukanov K. K. , Vorobyova O. M. , Zabrodskaya Yu. M. , Potemkina E. G. , Ushanov V. V. , Tastanbekov M. M. , Ivanova N. E. 
Published: September 2022

Introduction. Meningiomas are the second most common central nervous system (CNS) tumors in adults. most meningiomas are benign tumors. Anaplastic and atypical meningiomas account for 25% and have a high recurrence rate even after radical tumor resection and radiotherapy. The prognosis of patients with anaplastic meningiomas remains disappointing; most of them die within the first 2 to 5 years after surgery. Purpose: to discuss the challenges in diagnosis and treatment of recurrent meningiomas, to identify the causes of tumor progression, and to assess the clinical features and radiographic findings as well as specific pathomorphological and molecular genetic characteristics. material and methods. We searched for publications in the Pubmed, EMBASE, Cohrane Library and eLibrary databases published between January 2000 and January 2019 on the issue of recurrent intracranial meningiomas, in particular atypical and anaplastic meningiomas. Results. The review systematizes data on the prognostic factors for survival, relapse-free period, and disease progression. particular attention was paid to the radical resection of the tumor and the assessment of the grade of anaplasia. The current data on radiotherapy and drug therapy were presented. the controversial issues of approaches to the assessment of morphological prognostic criteria were discussed. The current knowledge on the most common genetic mutations in meningiomas, the prospects for their study and use for targeted therapy were presented. Conclusion. The management of meningioma still presents some unresolved issues. There are no optimal standards for diagnosis and treatment of patients with meningiomas that would take into account biological characteristics, including growth characteristics and molecular genetic profile. There are no clear prognostic criteria for recurrence and continuity in further management after surgical treatment, which affects the mortality rate and quality of life in this category of patients. New fundamental data that will determine a different strategy in the treatment of intracranial meningiomas are needed.
Polarization of macrophages: mechanisms, markers and factors of induction
Authors: Fedorov A. A. , Ermak N. A. , Gerashchenko T. S. , Topolnitskii E. B. , Shefer N. A. , Rodionov E. O. , Stakheyeva M. N. 
Published: September 2022

Macrophages are key components of the innate immune system. The variability of the macrophage’s participation in tumor progression, determined by their functional polarization, opens up a wide prospect for modulating their functional profile, primarily in the direction of increasing antitumor activity.The purpose of the studywas to provide up-to-date data on the process of macrophage polarization, mechanisms of its regulation, polarization markers and induction factors.Material and methods. A search was made for available literature sources published in Web of Science, Scopus and other databases. more than 160 sources devoted to the study of the process of macrophage polarization were found, of which 121 were included in this review.Results. This review presents data on the molecular mechanisms and gene signatures associated with M1 and M2 polarization of macrophages. We displayed information on metabolic, phenotypic characteristics and cytokine profile of M1- and M2-macrophages, as well as highlighted data on polarization factors and targets of their action.Conclusion. The information presented in the review can serve as an information base for the development of experimental and clinical approaches for editing the functional profile of macrophages in order to control their involvement in various pathological processes.
A clinical case of repeat use of PARP inhibitors in a patient with <i>mBRCA</i>-associated ovarian cancer
Authors: Villert A. B. , Kolomiets I. A. , Fesik Y. A. , Ivanova A. A. , Yunusova N. V. , Churuksaeva О. N. 
Published: September 2022

Backgraound. High-grade serous ovarian carcinoma (HGSOC) is the most common type of ovarian cancer. The prevalence of BRCA1/2 germline mutations is the highest in HGSOC. patients with germline BRCA gene mutations are more likely to respond to platinum-based chemotherapy. Clinical trials demonstrate the effectiveness of PARP inhibitors in the treatment of BRCA-associated ovarian cancer. Re-administration of PARP inhibitors after response to platinum-based chemotherapy demonstrates an increase in progression-free survival rates regardless of BRCA status. it is important for understanding the development of molecular mechanisms of resistance to platinum drugs and PARP inhibitors, as well as for developing new treatment strategies and tools to overcome resistance. Case description. This clinical case of BRCA-associated hereditary ovarian cancer demonstrates the efficacy and good tolerability of PARP inhibitor maintenance therapy following the treatment of the first relapse, as well as the efficacy of re-administration of PARP inhibitors following the treatment of the second relapse. The short-course of re-treatment with PARP inhibitors was accompanied by the development of multidrug resistance. the overall survival time was 112 months. Conclusion. The presence of mutations in BRCA1/2 genes is a promising justification for the administration of maintenance therapy with PARP inhibitors. Re-administration of PARP inhibitor maintenance therapy for relapsed ovarian cancer is currently being considered as a possible therapeutic option. deciphering the molecular mechanisms of resistance to PARP inhibitors is of paramount importance for the development of new treatment strategies and tools to overcome chemoresistance, re-sensitization of the tumor to platinum-based drugs or PARP inhibitors.
Relationship of the epithelial-mesenchimal transition expression markers with clinical and morphological parameters of colon cancer
Authors: Sinyanskiy L. E. , Krakhmal N. V. , Naumov S. S. , Patalyak S. V. , Afanasyev S. G. , Vtorushin S. V. 
Published: September 2022

The treatment of colon cancer with a mesenchymal-like phenotype poses a great challenge. Purpose of the study: to research expression of FRMD6, ZEB1, HTR2B, CDX2 in the primary tumor tissue with relation of the clinical and pathological features of colon cancer. Material and methods. a combined analysis of the expression of FRMD6, ZEB1, HTR2B, CDX2 with pathological criteria was performed in 100 patients with T1–4bN0–2bM0 colon cancer. Results of the study show that tumors with mesenchymal signs are characterized by a large size of the primary tumor, a high grade of differentiation, regional metastases, and eventually advanced stage of the disease. The frequency and expression levels of FRMD6, ZEB1 and HTR2B are depended of grade of adenocarcinoma. in cases with positive expression and a high percentage of expression of these proteins in the cancer cells, the degree of tumor morphological anaplasia increases. Conclusion. The study made it possible to reveal the relationship of IHC markers (FRMD6, ZEB1, HTR2B, CDX2) with tumor characteristics that determine the outcome. The studied markers may have prognostic and predictive value in treatment approaches of colon cancer.
Atypical clinical manifestations and genotype-phenotype correlations of neurofibromatosis type 1
Authors: Mustafin R. N. 
Published: September 2022

Purpose of the study: Analysis of available data on geno-phenotypic correlations and atypical forms of neurofibromatosis type 1. Material and methods. We searched for relevant sources in the Scopus, Web of Science, PubMed systems, including publications from May 1993 to October 2021. Of the 318 studies we identified, 59 were used to write a systematic review. Results. We found studies describing atypical forms of neurofibromatosis type 1 with an erased course without manifestation of a tumor syndrome, which are caused by specific mutations in the NF1 gene (causing substitutions of amino acids in neurofibromin: p.Arg1038, p.Met1149, p.Arg1809, or deletion of amino acids: p.Met990del, p.Met992del). NF1 patients with microdeletions are characterized by more severe disease symptoms (more often facial dysmorphism, skeletal and cardiovascular abnormalities, learning difficulties, and symptomatic spinal neurofibromas). mutations of splicing sites and extended deletions of the NF1 gene are associated with early manifestation of tumors, mutations at the 5’-end of the gene, causing a shortening of the protein product, are associated with optic nerve gliomas. the mutation c.3721C>T (p.R1241*) correlated with structural brain damage, and c.6855C>A (p.Y2285*) with endocrine disorders. the manifestations of NF1, similar to lipomatosis and Jaffe-Campanacci syndrome, not associated with a specific type of mutation are described. Conclusion. In spite of pronounced clinical variability of the disease, even among members of the same family, several studies have described genotype-phenotype correlations. Therefore, the role of modifier genes and epigenetic factors in the pathogenesis of NF1 is assumed, since the neurofibromin protein has a complex structure with several functional domains. It has been shown that the severity of the tumor syndrome is influenced by the methylation characteristics of NF1 gene and adjacent areas. in addition, NF1 gene is associated with a variety of microRNAs. therefore, targeted therapy aimed at specific non-coding RNAs to restore normal expression of NF1 gene can become a promising treatment for NF1.
Rainfall–runoff modeling using adaptive neuro-fuzzy inference system (ANFIS) and genetic algorithm (GA)
Authors: Vakili Shabnam , Mousavi Seyed Morteza 
Published: September 2022

Abstract
Nonlinear properties and natural uncertainties in the rainfall–runoff process, the necessity of extensive data, and the complexity of the physical models have caused researchers to use methods inspired by nature such as artificial neural networks, fuzzy systems, and genetic algorithms (GA). The main purpose of this study was to estimate runoff employing Adaptive Neuro-Fuzzy Inference System (ANFIS) and GA models using accessible, applicable, and easily available climatic data. The results of the two models were compared to provide an easy but reliable model to estimate evaporation. The models were utilized to estimate the runoff in Sivand river basin located in Fars province in central Iran. The results were compared considering a range of model performance indicators as mean absolute error (MAE), Nash–Sutcliffe efficiency coefficient (NSE), root mean square error (RMSE), and correlation coefficient (R2). According to the results presented, ANFIS with lower RMSE and MAE and higher correlation coefficient and NSE between the observed and predicted values provided higher accuracy in comparison to GA. Also, it was clear that using ANFIS, an increase in the number of membership functions and running cycles of the model decreased the error such that the results in the studied stations using were improved by 42, 44 and 11%, respectively by increasing the number of membership functions and run rounds. Also, it was observed that the nonlinear models performed better than the linear models when applying GA such that non-linearizing the model improved the results of the GA model in the three studied stations by 27.5%, 17%, and 9.5%, respectively. Meanwhile, considering RMSE amounts the best results from ANFIS were 23%, 54.6%, and 35.7% better than the best results from GA in the three stations, respectively. According to the results of the study runoff can be estimated appropriately by utilizing ony meteorological data and there is no need for more complex and interdependent data. A sensitivity analysis was conducted too by removing rainfall and evaporation parameters in two different scenarios. The ANFIS model showed the lowest sensitivity to the absence of those parameters especially evaporation in scenario 3 with RMSE = 0, 0, and −0.005 for Chambian, Dashtbal, and Tang Balaghi stations, respectively. The results of the study justifies using ANFIS employing only meteorological data to estimate runoff in areas when scant data are available.