bluuebunny/crossref_metadata_2025_split huggingface dataset:
Broadband Metamaterial Solar Absorbers Based on the Earth First-Rate Temperature-Insensitivity Metals for High Temperature Energy Harvesting
Authors: Ouabida Elhoussaine 
Published: January 2022

Abstract
Artificially engineered solar absorbers, known as metamaterial solar absorbers (MSA), are yielding new opportunities for designing new photons management systems. Further, the noble metals are indispensable in creating MSA owing to their plasmonic resonance in a desired spectral region. Nevertheless, in high temperature applications, the noble metals suffer from low melting points that make their uses largely impractical. In this work, the solution of using four of the Earth first-rate temperature-insensitivity metals in a proposed MSA is investigated. The proposed MSA structure is composed of high melting point metals (HMPM), deposited on a magnesium fluoride (MgF 2 ) dielectric spacer and a tungsten continuous plate. Meanwhile, owing to the dependence of MSA properties on structural parameters rather than band structure or chemistry, a geometrical optimization of the proposed absorbers is reported. Furthermore, the proposed MSA performance is investigated by computing the absorption spectrums. Results show relatively long bandwidths in the visible and near-infrared regimes. Besides, an underlying mechanism of the absorption enhancement with the corresponding electromagnetic field distributions are elucidated in detail. The calculated results indicate that the proposed MSA present wide bandwidths owing to the excitation of resonance modes of surface plasmons, dipolar interactions and cavity modes. Equally important, absorption measurements under wide polarization angles show polarization-insensitive high absorption at higher wavelengths, which is among the most important factors for an ideal solar absorber. The conclusion of this investigation is undoubtedly important, specifically that the proposed HMPM-based MSA would be the best choice for energy harvesting in high temperature applications.
Identification of Biomarkers Modulating Osteogenic Differentiation With Immune and Inflammation Landscapes in Mesenchymal Stem Cells: A Bioinformatics-based Comprehensive Study
Authors: Feng Ziyi , Su Xin , Wang Ting , Guo Shu 
Published: January 2022

Abstract
Background: Inducing osteogenic mesenchymal stem cell (MSC) differentiation brings a huge potential for clinical bone defect repair. This present study is aimed to identify novel key biomarkers for osteogenesis of MSCs, and analyze their possible regulation roles on immune and inflammation during this process.Results: Seven datasets (GSE159137, GSE159138, GSE114117, GSE88865, GSE153829, GSE63754, GSE73087) were obtained from the gene expression omnibus database, and 200 differentially expressed genes (DEGs) were identified from the train datasets. Biomarkers were screened through Logical regression of the selection operator algorithm, whose expressions and diagnostic performances were verified in the test datasets. FKBP prolyl isomerase 5 (FKBP5), insulin like growth factor binding protein 2, prostaglandin E receptor 2, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) and transmembrane O-mannosyltransferase targeting cadherins 1 were established to be osteogenesis-related biomarkers. Finally, the DEGs of immune and inflammation in osteogenesis were detected, and their correlation with the hub biomarkers were analyzed. The five selected biomarkers are strongly associated with immune and inflammation related genes.Conclusion: Taken together, our manuscript identified five biomarkers related to stem cells osteogenesis and discussed their potential perspectives in immunoregulation, inflammation and tissue engineering during the process.
Rapid Centralised Randomisation in Emergency Setting Trials Using a Smartphone
Authors: Badurdeen Shiraz , Hodgson Kate , Santomartino Georgia A , Stevens Luke , Donath Susan , Roberts Calum , Manley Brett , Polglase Graeme R , Hooper Stuart B , Davis Peter G , Blank Douglas A 
Published: January 2022

Abstract
Randomised trials in emergency settings must quickly confirm eligibility and allocate participants to an intervention group without delaying treatment. We report rapid randomisation during two neonatal resuscitation trials using the non-commercial REDCap platform accessed via smartphone. This simple, reliable method has wide applicability for trials in emergency settings.
Inflammatory Modulation of miR-155 Inhibits Doxorubicin‑Induced Testicular Dysfunction Via Sirt1/Foxo1 Pathway: Insight to the Role of Acacetin and Bacillus Cereus Protease
Authors: Anwar Hend Mohamed , Hamad Sherin Ramadan , Salem Gad Elsayed Mohamed , Soliman Rania Hassan Mohamed , Elbaz Eman 
Published: January 2022

Abstract
Purpose Doxorubicin (DOX), a chemotherapeutic agent, can disrupt testicular function leading to male infertility. The present study aimed to explore the possible protective effect of natural flavone, acacetin (ACA), and protease of Bacillus Cereus bacteria (B. Cereus) as well as the potential role of miR-155/SIRT1/FOXO1 network in DOX-induced testicular toxicity. Methods Twenty-eight male Wistar rats were randomly allocated into four groups and treated as follows: Control (1% DMSO 1 mL/kg/day; p.o), DOX (1mg/kg, i.p) on every other day for 21 days with a cumulative dose equal to 10 mg/kg throughout the experimental period, pre-treated groups received ACA (5 mg/kg/day, p.o) or B. Cereus protease (36 mg/kg/day, p.o) for a week prior DOX administration. Results DOX challenge reduced serum testosterone, and testicular 17β-hydroxysteroid dehydrogenase (17β-HSD). DOX exhibited a significant increase in testicular oxidative stress, inflammatory and apoptotic markers. Aberrant testicular miR-34c, a germ-specific miRNA, and miR-155 expressions were observed, along with decreased protein expression of sirtuin1 (SIRT1) dependent forkhead box 1 (FOXO1) acetylation inducing apoptosis. Besides, abnormal histopathological architecture and a marked reduction in the testicular expression of proliferating cell nuclear antigen (PCNA) were detected. ACA or protease administration significantly improves the histopathological and immunohistochemical pictures compared to DOX alone and renovated testicular functions. Nevertheless, treatment with protease was more effective than treatment with ACA in ameliorating DOX-induced testicular toxicity. Conclusion This study reveals the prophylactic role of these two regimens on male fertility by exhibiting antioxidant, anti-inflammatory, and anti-apoptotic effects against DOX-elicited testicular toxicity, possibly via modulating miR-155/SIRT1/FOXO1 network.
Development and Pilot Testing of the 2019 Canadian Abortion Provider Survey
Authors: Renner Regina , Ennis Madeleine , Maazi Mahan , Dunn Sheila , Norman Wendy V , Kaczorowski Janusz , Guilbert Edith 
Published: January 2022

Abstract
Background
Substantial changes in abortion care regulations, available medications and national clinical practice guidelines have occurred since a 2012 national Canadian Abortion Provider Survey (CAPS). We developed and piloted the CAPs 2019 to explore changes of the abortion provider workforce, their clinical care as well as experiences with stigma and harassment.
Methods
We undertook development and piloting in three phases: (1) development of the preliminary survey sections and questions based on the 2012 survey instrument, (2) content validation and feasibility of including certain content aspects via a modified Delphi Method with panels of clinical and research experts, and (3) pilot testing of the draft survey for face validity and clarity of language; assessing usability of the web-based Research Electronic Data Capture platform including the feasibility of complex skip pattern functionality. We performed content analysis of phase 2 results and used a general inductive approach to identify necessary survey modifications.
Results
In Phase 1 we generated a survey draft that reflected the changes in Canadian abortion care regulations and guidelines and included questions for clinicians and administrators providing first and second trimester surgical and medical abortion. In phase 2, we held 6 expert panel meetings of 5-8 participants each representing clinicians, administrators and researchers to provide feedback on the initial survey draft. Due to the complexity of certain identified aspects, such as interdisciplinary collaboration and interprovincial care delivery differences, we revised the survey sections through an iterative process of meetings and revisions until we reached consensus on constructs and questions to include versus exclude for not being feasible. In phase 3 we made minor revisions based on pilot testing of the bilingual, web-based survey among additional experts chosen to be widely representative of the study population. We included complex branching logic so each respondent only viewed applicable questions based on their prior responses.
Conclusions
We developed and piloted the CAPS 2019 survey instrument suitable to explore characteristics of a complex multidisciplinary workforce, their care and experience with stigma on a national level, and that can be adapted to other countries.
Hazardous spent methanol synthesis catalyst, bauxite red mud and ground cooled ferrous slag application to produce sustainable ceramics
Authors: Mymrin Vsevolod , Alarcon Reinaldo H. G. , Guidolin Marilia A. , Klitzke Walderson , Avanci Monica A. , Rolim Paulo H.B. , Carvalho Karina Q. , Catai Rodrigo E. 
Published: January 2022

Abstract
New composites of sustainable ceramic composites from hazardous methanol synthesis catalyst waste, bauxite red mud and ground cooled ferrous slag were developed in this study. The ceramics were sintered at temperatures of 900°, 1000°, 1050°, 1100° and 1150°C for one hour. Almost all ceramic demonstrated fairly high properties, starting from a firing temperature of 1000°C. The best results were obtained after firing at 1050°С, which reached 25.98 MPa of flexural resistance, 8.80% of water absorption, 3.46 g/cm3 and 7.14% of linear shrinkage. Studies of physical – chemical processes of the ceramics’ structure formation by XRD, SEM / EDS / mapping and LAMMA methods show the synthesis of mainly amorphous new formations with strong glass-like structures. Therefore, the result of leaching and solubility of the initial components’ heavy metals in acid environment by the method of atom-absorption spectroscopy indicated their almost complete immobilization, which far exceeded the demands of Brazilian sanitary norms.
The Whole-Transcriptome Landscape of Diabetes-Related Sarcopenia Reveals the Specific Function of Novel lncRNA Gm20743
Authors: Yu Jing , Loh kim , Yang He-qin , Du Meng-ran , Wu Yong-xin , Liao Zhi-yin , Guo Ai , Yang Yun-fei , Chen Bo , Zhao Yu-xing , Chen Jin-liang , Zhou Jing , Sun Yue , Xiao Qian 
Published: January 2022

Abstract
Background: While the exact mechanism remains unclear, type 2 diabetes mellitus (T2DM) has been shown to increase the risk of sarcopenia that is characterized by decreased muscle mass, strength, and function. This study aimed to identify the pathophysiological role of lncRNAs in diabetic sarcopenia. Methods: Whole-transcriptome RNA sequencing was performed on the gastrocnemius from the overt diabetes-induced sarcopenia model of db/db mice. Informatics and co-expression networks were performed to predict key lncRNAs and their potential regulation circuits in diabetes-induced sarcopenia. To determine the specific function of lncRNA Gm20743, the detection of Mito-Sox, reactive oxygen species, Ethynyl-2′-deoxyuridine, and myosin heavy chain was performed in overexpressed-Gm20743 C2C12 cells. Results: RNA-seq data and informatics revealed the key lncRNA-mRNA interactions and indicated a potential regulatory role of lncRNAs. Meanwhile, we characterized three core candidate lncRNAs Gm20743, Gm35438, and 1700047G03Rik and their potential function. Furthermore, the results suggested lncRNA Gm20743 may be involved in regulating mitochondrial function, oxidative stress, cell proliferation, and myotube differentiation in skeletal muscle cells. Conclusion: These findings significantly improve our understanding of lncRNAs that may mediate muscle mass, strength, and function in diabetes and represent potential therapeutic targets for diabetes-induced sarcopenia.
Molecular mapping and transfer of a novel brown planthopper resistance gene bph42 from Oryza rufipogon (Griff.) to cultivated rice (Oryza sativa L.)
Authors: Kaur pavneet , Neelam Kumari , Sarao Preetinder Singh , Babbar Anika , Kumar Kishor , vikal yogesh , Khanna Renu , Kaur Rupinder , Mangat G.S. , Singh Kuldeep 
Published: January 2022

Abstract
Brown planthopper (BPH), Nilaparvata lugens (Stål), is one of the most destructive pests of rice accounting for 52% of annual yield loss. Under severe conditions, BPH cause “hopper burn” leading to drying and lodging of the matured plant. Utilization of host-plant resistance from diverse germplasm is considered as cost-effective and environment-friendly approach for its management. The current study reports the identification and mapping of a novel source of resistance from wild species of rice O. rufipogon accession CR100441 against the BPH biotype 4. Genetic analysis was performed using 276 BC2F2 and 233 BC2F3 populations derived from a cross of O. rufipogon accession CR100441 and highly susceptible cultivar PR122. The segregation of susceptible to resistant plants 3:1 ratio (210:66, χ2c = 0.17 ≤ χ20.05,1=3.84) indicating the presence of single major recessive gene. Bulked segregant analysis (BSA) using 537 SSR markers mapped a BPH resistance gene (designated as bph42) on the short arm of chromosome 4 between RM16282 and RM16335. QTL analysis identified a peak marker RM16335 contributing 29% of phenotypic variance at 11.0 LOD. This marker co-segregates with the bph42 which could be efficiently used for marker-assisted selection (MAS) to transfer of the traits into elite rice cultivars.
Characteristics of Complete Mitochondrial Genomes Reveals a Potential Division of Genus Modiolus into Three Genera
Authors: Li Houmei , Ma Peizhen , Liu Yumeng , Li Cui , Li Chenghua , Wang Haiyan , Zhang Zhen 
Published: January 2022

Abstract
Backgrounds Mussels have been one of the most abundant and highly evolved marine biological groups with high level of genetic differentiation between and within species. The yellow-banded horse mussel, Modiolus modulaides (Röding, 1798), is an important economic species in Philippines and an endangered species in Japan, with no whole mitogenome characterized. Methods and Results In this study, we sequenced the whole mitochondrial genome of Modiolus modulaides (Röding, 1798), a medium-sized mussel collected from Guangxi, China. Result shows a 15,422 bp closed-circular DNA molecule, including 12 protein-coding genes, 22 transfer RNA genes and two ribosomal RNA genes. The genome composition is obviously A+T biased (62.5%), with 23.1% A, 39.4% T, 25.4% G and 12.0% C, making AT-skew and GC-skew being -0.26 and 0.36, respectively. Phylogenetic analysis of Modiolus modulaides and other 36 mussel species based on 12 protein-coding genes and two ribosomal RNAs of mitogenomes shows that Modiolus modulaides is most closely related with Modiolus phillippinum (Hanley, 1843).Conclusions A hypothesis that the current genus Modiolus should be separated three distinctive genera was raised based on morphological and phylogenetic characteristics, as well as gene patterns of mitogenomes. These results put forward new insight of phylogenetic relationship of Modiolus species and will help to further study the taxonomy and phylogeny of Mytilidae.
Urine exosomes biomarkers of Obesity treatment: A pilot study
Authors: Vijay Bhavya , Rao Satish P Ramachandra , Devkumar Poornima 
Published: January 2022

Abstract
BackgroundObesity is a raising risk factor for many diseases including Cardiovascular risks and Cancer. The present limitations and inaccuracy of anthropometric measures as well as treatment options demand research of integrative management strategies and identification of specific biomarkers of obesity. This study identifies the urine exosome biomarkers and its differential expression profile between 3-timepoints from female obese participants who underwent Ayurveda treatment.MethodologyUrine exosomes were isolated using PEG methods of isolation. The major proteins obtained were identified using label-free quantification in LC-MS/MS. The genes involved in pathway enrichment, functional annotation and disease manifestation were identified and shortlisted based on protein interaction network. The hub genes representing obesity are identified.ResultsThe exosomes isolated were validated using LC-MS/MS. Using UniProt as reference, a total of 210 exosome proteins were identified. 73 genes were overexpressed in pathway enrichment analysis. Further, GO functional annotation identified 15 common genes involved. Finally, the 8 genes common in obesity were identified and its differential expression profile was seen to have corrected at timepoints during treatment.ConclusionThis is the first study to isolate and identify urine exosomes profiles from female obese participants of India. The study results indicate the correction in the differential expression profile of 8 hub genes involved in obesity post treatment. The biomarker signature of the pilot study indicates the specificity of urine exosomes as diagnostic markers. The study also promotes the potential of integrative and complementary treatment approaches like Ayurveda in effective management of many metabolic diseases.
The KIDSCREEN-27 scale: translation and validation study of the Slovenian version
Authors: Budler Leona Cilar , Pajnkihar Majda , Ravens-Sieberer Ulrike , Barr Owen , Stiglic Gregor 
Published: January 2022

Abstract
Background: There are many methods available for measuring social support and quality of life (QoL) of adolescents, of these, the KIDSCREEN tools are most widely used. Thus, we aimed to translate and validate the KIDSCREEN-27 scale for the usage among adolescents aged between 10 and 19 years old in Slovenia.Methods: A cross-sectional study was conducted among 2 852 adolescents in primary and secondary school from November 2019 to January 2020 in Slovenia. 6-steps method of validation was used to test psychometric properties of the KIDSCREEN-27 scale. We checked descriptive statistics, performed a Mokken scale analysis, parametric item response theory, factor analysis, classical test theory and total (sub)scale scores.Results: All five subscales of the KIDSCREEN-27 formed a unidimensional scale with good homogeneity and reliability. The confirmatory factor analysis showed poor fit in user model versus baseline model metrics (CFI = 0.847; TLI = 0.862) and good fit in root mean square error (RMSEA = 0.072; p(χ2) < 0.001). A scale reliability was calculated using Cronbach's α (0.93), beta (0.86), G6 (0.95) and omega (0.93).Conclusions: The questionnaire showed good psychometric properties and can be used among adolescents in Slovenia to find out about their quality of life.
Photogenerated Reactive Oxygen Species and Hyperthermia by Cu3SnS4 Nanoflakes for Advanced Photocatalytic and Photothermal Antibacterial Therapy
Authors: Yang Yangzi , Wang Chengwei , Wang Ning , Li Jiaxin , Zhu Yingchun , Zai Jiantao , Fu Jingke , Hao Yongqiang 
Published: January 2022

Abstract
BackgroundThe rapid spread of infectious bacteria has brought great challenges to public health. It is imperative to explore effective and environment-friendly antibacterial modality to defeat antibiotic-resistant bacteria with high biosafety and broad-spectrum antibacterial property. ResultsHerein, biocompatible Cu3SnS4 nanoflakes (NFs) were prepared by a facile and low-cost fabrication procedure. These Cu3SnS4 NFs could be activated by visible light, leading to visible light-mediated photocatalytic generation of a myriad of reactive oxygen species (ROS). Besides, the plasmonic Cu3SnS4 NFs exhibit strong near infrared (NIR) absorption and a high photothermal conversion efﬁciency of 55.7%. The ROS mediated cellular oxidative damage and the NIR mediated photothermal disruption of bacterial membranes collaboratively contributed to the advanced antibacterial therapy, which has been validated by the efficient eradication of both Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus strains in vitro and in vivo. Meanwhile, the exogenous copper ions metabolism from the Cu3SnS4 NFs facilitated the endothelial cell angiogenesis and collagen deposition, thus expediting the wound healing. Importantly, the inherent localized surface plasmon resonance effect of Cu3SnS4 NFs empowered them as an active substrate for surface-enhanced Raman scattering (SERS) imaging and SERS-labeled bacteria detection. ConclusionsThe low cost and biocompatibility together with the solar-driven broad-spectrum photocatalytic/photothermal antibacterial property of Cu3SnS4 NFs make them a candidate for sensitive bacteria detection and effective antibacterial treatment.
Designing A Provincial Surveillance and Support System for Childhood Cancer Survivors
Authors: Shuldiner Jennifer , Shah Nida , Reis Catherine , Chalmers Ian , Ivers Noah , Nathan Paul 
Published: January 2022

Abstract
Background Survivors of childhood cancer are at lifelong risk of morbidity (such as new cancers or heart failure) and premature mortality because of their cancer treatment. These are termed late effects. Therefore, they require lifelong, risk-tailored surveillance. However, most adult survivors of childhood cancer do not complete recommended surveillance tests such as mammograms or echocardiograms. Working with survivors, family physicians, and health-system partners, we are designing a provincial support system for high-priority tests, informed by principles of implementation science, behavioral science and design-thinking. Methods Our multi-phase process was as follows: Step 1: a qualitative study to explore intervention components essential to accessing surveillance tests; Step 2: a workshop with childhood cancer survivors, family physicians and health system stakeholders that used the Step 1 findings and ‘personas’ (a series of fictional but data-informed characters) to develop and tailor the intervention for different survivor groups Step 3: intervention prototype development; and step 4: iterative user-testing. Results The qualitative study of 30 survivors and 7 family physicians found a high desire for information on surveillance for late effects. Respondents indicated that in addition to providing personalized information, the intervention should help patients book appointments when they are due. Insights from the workshop included the importance of partnering with both family physicians and survivorship clinics and providing emotional support for survivors that may experience distress upon learning of their risk for late effects. In our user-testing process, prototypes went through iterations that incorporated feedback from users regarding usability and functionality. We sought to address the needs of survivors and physicians while balancing the capacity and infrastructure available for a life-long intervention via our health system partners. Conclusion In partnership with childhood cancer survivors, family physicians, and health-system partners, we elucidated the barriers and enablers to accessing guideline-recommended surveillance tests and designed a multi-faceted solution that will support survivors and their family physician. The next step is to evaluate the intervention in a pragmatic randomized control trial.