bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manipulating the interlayer carrier diffusion and extraction process in organic-inorganic heterojunctions: from 2D to 3D structures
Authors: Qiao Jia-Wei , Zhang Wen-Qing , Cui Feng-Zhe , Yin Hang , Feng Lin , Hao Xiao-Tao 
Published: January 2022

AbstractInterlayer carrier transfer at heterointerfaces plays a critical role in light to electricity conversion using organic and nanostructured materials. However, how interlayer carrier extraction at these interfaces is poorly understood, especially in organic-inorganic heterogeneous systems. Here, we provide a direct strategy for manipulating the interlayer carrier diffusion process, transfer rate and extraction efficiency in tetracene/MoS2 type-II band alignment heterostructure by constructing the 2D–3D organic-inorganic (O-I) system. As a result, the prolonged diffusion length (12.32 nm), enhanced electron transfer rate (9.53 × 109 s−1) and improved carrier extraction efficiency (60.9%) are obtained in the 2D O-I structure which may be due to the more sufficient charge transfer (CT) state generation. In addition, we have demonstrated that the interlayer carrier transfer behavior complied with the diffusion mechanism based on the one-dimensional diffusion model. The diffusion coefficients have varied from 0.0027 to 0.0036 cm2 s−1 as the organic layer changes from 3D to 2D structures. Apart from the relationship between the carrier injection and diffusion process, temperature-dependent time-resolved spectra measurement is used to reveal the trap-related recombination that may limit the interlayer carrier extraction. The controllable interlayer carrier transfer behavior enables O-I heterojunction to be optimized for optoelectronic applications.
Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics
Authors: Ito Kenichiro , Matsuda Yoshihiko , Mine Ayako , Shikida Natsuki , Takahashi Kazutoshi , Miyairi Kyohei , Shimbo Kazutaka , Kikuchi Yoshimi , Konishi Atsushi 
Published: January 2022

AbstractMimetics of growth factors and cytokines are promising tools for culturing large numbers of cells and manufacturing regenerative medicine products. In this study, we report single-chain tandem macrocyclic peptides (STaMPtides) as mimetics in a new multivalent peptide format. STaMPtides, which contain two or more macrocyclic peptides with a disulfide-closed backbone and peptide linkers, are successfully secreted into the supernatant by Corynebacterium glutamicum-based secretion technology. Without post-secretion modification steps, such as macrocyclization or enzymatic treatment, bacterially secreted STaMPtides form disulfide bonds, as designed; are biologically active; and show agonistic activities against respective target receptors. We also demonstrate, by cell-based assays, the potential of STaMPtides, which mimic growth factors and cytokines, in cell culture. The STaMPtide technology can be applied to the design, screening, and production of growth factor and cytokine mimetics.
Curvature and self-assembly of semi-conducting nanoplatelets
Authors: Guillemeney Lilian , Lermusiaux Laurent , Landaburu Guillaume , Wagnon Benoit , Abécassis Benjamin 
Published: January 2022

AbstractSemi-conducting nanoplatelets are two-dimensional nanoparticles whose thickness is in the nanometer range and controlled at the atomic level. They have come up as a new category of nanomaterial with promising optical properties due to the efficient confinement of the exciton in the thickness direction. In this perspective, we first describe the various conformations of these 2D nanoparticles which display a variety of bent and curved geometries and present experimental evidences linking their curvature to the ligand-induced surface stress. We then focus on the assembly of nanoplatelets into superlattices to harness the particularly efficient energy transfer between them, and discuss different approaches that allow for directional control and positioning in large scale assemblies. We emphasize on the fundamental aspects of the assembly at the colloidal scale in which ligand-induced forces and kinetic effects play a dominant role. Finally, we highlight the collective properties that can be studied when a fine control over the assembly of nanoplatelets is achieved.
Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state
Authors: Hernandez Gloria E. , Ma Feiyang , Martinez Guadalupe , Firozabadi Nadia B. , Salvador Jocelynda , Juang Lih Jiin , Leung Jerry , Zhao Peng , López Diego A. , Ardehali Reza , Beaudin Anna E. , Kastrup Christian J. , Pellegrini Matteo , Flick Matthew J. , Iruela-Arispe M. Luisa 
Published: January 2022

AbstractLeukocytes and endothelial cells frequently cooperate to resolve inflammatory events. In most cases, these interactions are transient in nature and triggered by immunological insults. Here, we report that, in areas of disturbed blood flow, aortic endothelial cells permanently and intimately associate with a population of specialized macrophages. These macrophages are recruited at birth from the closing ductus arteriosus and share the luminal surface with the endothelium, becoming interwoven in the tunica intima. Anatomical changes that affect hemodynamics, such as in patent ductus arteriosus, alter macrophage seeding to coincide with regions of disturbed flow. Aortic resident macrophages expand in situ via direct cell renewal. Induced depletion of intimal macrophages leads to thrombin-mediated endothelial cell contraction, progressive fibrin accumulation and formation of microthrombi that, once dislodged, cause blockade of vessels in several organs. Together the findings reveal that intravascular resident macrophages are essential to regulate thrombin activity and clear fibrin deposits in regions of disturbed blood flow.
Defect-controlled softness, diffusive permeability, and mesh-topology of metallo-supramolecular hydrogels
Authors: Nicolella Paola , Koziol Martha Franziska , Löser Lucas , Saalwächter Kay , Ahmadi Mostafa , Seiffert Sebastian 
Published: January 2022

In a model 4-arm pEG supramolecular network, connectivity defects are systematically introduced with different ratios of 8-arm pEG, resulting in intra-molecular loops, and providing a softer polymer network and higher self-diffusion coefficients.
Prioritization‐based subsampling quality assessment methodology for mobility‐related information systems
Authors: Gomari Syrus , Knoth Christoph , Antoniou Constantinos 
Published: January 2022

AbstractMobility‐related information systems, such as on‐street parking information (OSPI) systems have become more popular in the original equipment manufacturer (OEM) industry over the last decade. However, there is a lack of methods to assess their quality at a large scale. This paper introduces a data‐driven methodology to measure the true quality by fleet data prioritization‐based subsampling strategies (PSSs). It is applied to the use case of OSPI using parking events (PE), but is applicable to other mobility‐related information systems utilizing their respective fleet data. PSSs are defined based on neighbourhoods and time periods. Each PSS generates a unique set of spatio‐temporally important areas at different quadkey zoom levels over 168 week‐hours, called slices. The importance weight in each slice depends on the volume of PE within them. The algorithm for each PSS automatically selects important areas and time frames that are vital to be observed. Sample prediction models are used for the benefits assessment of the methodology by comparing it against non‐prioritized randomized selection of ground truth. It is proven that the methodology can lessen the effort of ground truth collection, while maintaining the amount of information necessary to assess the true quality of a prediction model.
Modelling, analysis, and parameters design of filter‐integrated three‐switch boost inverter
Authors: Liu Shuo , Zhou Xu , Li Jianlin , Yang Liyong 
Published: January 2022

AbstractBy combining the filter circuit and boost circuit, the filter‐integrated three‐switch boost inverter (TSBI) is proposed in this paper. Different from the traditional boost inverter, TSBI achieves the boost function at the AC side, so the voltage stress on the switches is small. Through modelling and analysis, the boosting characteristics and filtering characteristics of the system are obtained. The proposed topology can significantly suppress the resonance spike and does not need to add additional filtering equipment, which can reduce the volume of equipment and system loss. In order to clearly illustrate the advantages and disadvantages of the proposed topology, this paper makes a detailed comparison with other types of inverters. Finally, the feasibility of the system is verified by experiment and simulation.
Reconstruction of the magnetic connection from Mercury to the solar corona during enhancements in the solar proton fluxes at Mercury
Authors: Ippolito A. , Plainaki C. , Zimbardo G. , Alberti T. , Massetti S. , Milillo A. , Orsini S. 
Published: January 2022

Aims. We study the magnetic connection between Mercury and the solar corona based on energetic proton events measured near Mercury by MESSENGER during 2011−2013 in order to identify the possible source of the accelerated particles on the solar surface.
Methods. The transport of the magnetic field lines in the heliosphere was evaluated with a Monte Carlo code that gives a random displacement at each step of the integration along the Parker magnetic field model. The simulation was tailored to each specific event by using the magnetic fluctuation levels obtained at Mercury by MESSENGER and the values of the solar wind velocity measured at 1 AU by the Advanced Composition Explorer satellite. We selected seven case studies for which an increase in the proton fluxes of at least two orders of magnitude with respect to the background level was observed. For each selected case, we took the background magnetic field map (magnetogram) at the source surface of the solar wind (r = 2.5 R⊙) into account. By considering the relative position of Mercury and the Earth on the day on which the enhancement in the proton fluxes was observed by MESSENGER, we obtained the position of the active regions on the solar surface as seen by Mercury.
Results. The footpoint of the Parker spiral passing Mercury was reconstructed for all of the selected events. By considering the values of the fluctuation levels of the interplanetary magnetic field recorded by MAG-MESSENGER two days before the event and the values of the fluctuation levels of the interplanetary magnetic field on the day on which the event was observed, we are also able to appreciate the effects on the solar wind magnetic field perturbations induced by the shock of the coronal mass ejection. This technique will also be useful for the interpretation of energetic particle observations by BepiColombo.
Influence of road traffic noise peaks on reading task performance and disturbance in a laboratory context
Authors: Lavandier Catherine , Regragui Mehdi , Dedieu Romain , Royer Carine , Can Arnaud 
Published: January 2022

The influence of fluctuating road traffic noise on perceived disturbance during a reading task as well as on performance, inside a living room with closed windows, is presented in this paper. Sixteen 2-min sound sequences were created combining two variables: the number of events (four levels varying from one to four car pass-bys) and the peak emergence above the background noise (four levels with a 5 dB(A) step) keeping limited variations ofLAmax, 1s. The noise impact was evaluated through a reading task of texts synchronized with the sound sequences, for participants classified into fast or slow readers, and sensitive or non-sensitive to noise. The comprehension rate of the texts decreases as the background sound level increases. The reading speed decreases during the rising front of a peak, and goes back to its former regular reading speed during the descending front of the peak. This slowdown during the rising front reaches 14% for slow readers. The declared disturbance is higher for slow readers compared to fast readers, and higher for noise sensitive persons compared to non-sensitive persons. The influence of the acoustic indicators on the reading disturbance is very small compared to the influence of personal factors. There is even no influence of the number of events on this disturbance.
Typical engineering design of potato micro-sprinkler irrigation in Northern Shanxi
Authors: He Jiewei , Chang Zhanqiang , Wang Ziyu , He Jiexun , Zhang Xue , Zhu Xueqi , Zhu Wantian 
Published: January 2022

The Loess Plateau in the northern part of Shanxi Province has uneven rainfall and large evaporation, so droughts often occur. The drought has restricted the development of the local planting industry and the economy. Micro sprinkler irrigation has the advantages of strong adaptability, saving water, saving labor and land, increasing production, and preventing salinization, which is very suitable for this area.
This micro-sprinkler irrigation design is carried out in typical plots, based on potato plant characteristics, rainfall data over the years, combined with corresponding specifications and actual conditions. This article uses a refraction micro-sprinkler with a spray diameter of 2.4 m. In the water transmission and distribution network, underground pipelines share 1,860 m of main pipes and sub-main pipes; surface pipelines share 1,200 m of branch pipes and 90,000 m of capillary pipes. The design meets the verification indicators of all irrigation groups, conforms to local actual conditions.
Construction and installation engineering for floating wind turbines
Authors: Crowle A.P. , Thies PR 
Published: January 2022

The construction and installation engineering of floating offshore wind turbines is important to minimize schedules and costs. Floating offshore wind turbine substructures are an expanding sector within renewable power generation, offering an opportunity to deliver green energy, in new areas offshore. The floating nature of the substructures permits wind turbine placement in deep water locations. This paper investigates the construction and installation challenges for the various floating offshore wind types. It is concluded that priority areas for project management and design engineers minimising steel used in semi submersible construction, reducing the floating draft of Spars and for Tension Leg Platforms developing equipment for a safe installation.
Specifically tailored design for construction and installation includes expanding the weather window in which these floating substructures can be fabricated, transported to and from offshore site and making mooring and electrical connection operations simpler. The simplification of construction methodology will reduce time spent offshore and minimise risks to installation equipment and personnel. The paper will include the best practice for ease of towing for offshore installation and the possible return to port for maintenance. The construction and installation process for a floating offshore wind turbine varies with substructure type and this will be developed in more detail in the paper. Floating offshore wind structures require an international collaboration of shipyards, ports and construction vessels, though to good project management. It is concluded that return to port for maintenance is possible for semi submersibles and barges whereas for Spars and TLP updated equipment is required to carry out maintenance offshore. In order to facilitate the construction and to minimize costs, the main aspects have to be considered i.e., the required construction vessel types, the distance from fit-out port to site and the weather restrictions.
Anästhesie und perioperatives Management der Karotis-Endarteriektomie (CEA)
Authors: Gaik Christine , Wiesmann Thomas 
Published: January 2022

ZusammenfassungDie Karotis-Endarteriektomie ist eine Standardoperation zur Therapie und Prophylaxe von ischämischen Schlaganfällen bei bestimmten Patientenkollektiven. Für eine optimale perioperative anästhesiologische Versorgung sind grundlegende Kenntnisse der Anatomie, Pathophysiologie sowie der OP-Technik notwendig. Mit der Allgemein- und der Regionalanästhesie stehen 2 verschiedene Anästhesieoptionen zur Wahl. Der Leser soll bei der Lektüre des Beitrags ein tiefergehendes Verständnis für die Erkrankung, die Operation und das daraus resultierende perioperative anästhesiologische Management erhalten.
Isolierte Zungenschwellung nach Penicillin und negative Allergieabklärung – alles in Butter?
Authors: Scherer Hofmeier Kathrin , Bircher Andreas J. 
Published: January 2022

ZusammenfassungPenicilline können alle Arten spezifischer Immunreaktionen nach der erweiterten Coombs- und Gell-Klassifikation auslösen und zählen zu den häufigsten Ursachen unerwünschter Arzneimittelreaktionen. Das diagnostische Armamentarium umfasst neben den verschiedenen Hauttests den Nachweis spezifischer IgE gegen allergene Determinanten am Betalaktam-Molekül und ggf. zelluläre Aktivierungstests. Im Fall negativer Ergebnisse bei den genannten Tests kann ggf. noch die Toleranz im Rahmen eines Provokationstestes nachgewiesen werden. Die Sensitivität der diagnostischen Tests ist – mit Ausnahme des Provokationstests – aber limitiert, und falsch negative Tests sind möglich. Wir präsentieren zwei Fälle mit einer isolierten Zungenschwellung nach Gabe von Amoxicillin bei vollständig negativem, wiederholtem allergologischen Work-up. Bei beiden Patienten konnte die Überempfindlichkeit nur mit einer Reexposition nachgewiesen werden.
Improved team communication in endoscopic procedures by digital enhanced telecommunication during the COVID-19 pandemic
Authors: Sturm Niklas , Perkhofer Lukas , Schulte Lucas , Mayer Benjamin , Seufferlein Thomas , Wagner Martin , Walter Benjamin M. 
Published: January 2022

Abstract
Background and study aims Unbiased communication is crucial for excellent teamwork in high-quality endoscopy. Personal protective equipment (PPE) (FFP-masks and face-shields) worn by endoscopists that are ubiquitous in the current COVID-19 pandemic strikingly impair communication. Digital enhancement approaches to maintain team communication, especially during complex endoscopic procedures, are urgently warranted.
Materials and methods A prospective, two-armed interventional study was performed at an endoscopy unit at a tertiary center in Germany. Two hundred and three endoscopic procedures with PPE se according to pandemic risk level were randomly assigned (1:1) to a group performed by an endoscopy team equipped with digital enhanced cordless telecommunication (DECT) or one without digital-enhanced communication. The primary outcome was the team-reported number of communication-associated events (CAEs) defined as misunderstandings that impaired workflow during endoscopic examination. Secondary outcomes included perceived voice and headphone quality and overall comfort with DECT during endoscopic work.
Results The use of DECT was associated with a significant reduction in communication-associated events in endoscopic procedures and overall, was perceived positively.
Conclusions Digital enhancement of communication is a promising and easy-to- establish tool for improving team communication quality in endoscopy.
Endoscopic management of cystic duct stones and Mirizzi’s syndrome: experience at an academic medical center
Authors: Pawa Rishi , Dorrell Robert , Pawa Swati 
Published: January 2022

Abstract
Background and study aims Cystic duct stones (CDS) are challenging to treat with conventional ERCP techniques due to the small diameter and tortuous nature of the cystic duct. There have been limited studies focused on endoscopic management of CDS. We present our experience managing CDS endoscopically and demonstrate that new advances in endoscopic technology have rendered CDS easier to manage.
Patients and methods From 2013 to 2020, we prospectively maintained a database of patients undergoing endoscopic management of CDS. ERCP was performed in all patients, and if unsuccessful in removing stones, cholangioscopy with electrohydraulic lithotripsy (EHL) was utilized. All patients were followed in clinic for outcomes.
Results Of 5,123 ERCPs performed at our institution during the study period, 21 patients were diagnosed with CDS. Six patients were successfully treated with conventional ERCP alone. Cholangioscopy with EHL was used in 15 patients undergoing 18 procedures to achieve stone clearance. CDS clearance was achieved in all patients. There was one adverse event (post-ERCP pancreatitis). Spyglass DS was associated with a significant decrease in average procedure time in comparison to first-generation SpyGlass (89.3 vs. 54.4 minutes, P = 0.004). Thirteen patients (87 %) were discharged from the hospital within 24 hours. The median follow-up duration was 23.2 months.
Conclusions Endoscopy should be the preferred management strategy for CDS, especially in patients with prior cholecystectomy. Surgical outcomes have been associated with high patient morbidity and hospital length of stay. Our case series is the largest cohort of CDS patients successfully managed with cholangioscopy and EHL in the United States.
UK Joint Advisory Group consensus statements for training and certification in endoscopic retrograde cholangiopancreatography
Authors: Siau Keith , Keane Margaret G , Steed Helen , Caddy Grant , Church Nick , Martin Harry , McCrudden Raymond , Neville Peter , Oppong Kofi , Paranandi Bharat , Rasheed Ashraf , Sturgess Richard , Hawkes Neil D , Webster George , Johnson Gavin ,   on behalf of the Joint Advisory Group on Gastrointestinal Endoscopy (JAG)
Published: January 2022

Abstract
Background and study aims Despite the high-risk nature of endoscopic retrograde cholangiopancreatography (ERCP), a robust and standardized credentialing process to ensure competency before independent practice is lacking worldwide. On behalf of the Joint Advisory Group (JAG), we aimed to develop evidence-based recommendations to form the framework of ERCP training and certification in the UK.
Methods Under the oversight of the JAG, a modified Delphi process was conducted with stakeholder representation from the British Society of Gastroenterology, Association of Upper Gastrointestinal Surgeons, trainees and trainers. Recommendations on ERCP training and certification were formulated after formal literature review and appraised using the GRADE tool. These were subjected to electronic voting to achieve consensus. Accepted statements were peer-reviewed by JAG and relevant Specialist Advisory Committees before incorporation into the ERCP certification pathway.
Results In total, 27 recommendation statements were generated for the following domains: definition of competence (9 statements), acquisition of competence (8 statements), assessment of competence (6 statements) and post-certification support (4 statements). The consensus process led to the following criteria for ERCP certification: 1) performing ≥ 300 hands-on procedures; 2) attending a JAG-accredited ERCP skills course; 3) in modified Schutz 1–2 procedures: achieving native papilla cannulation rate ≥80%, complete bile duct clearance ≥ 70 %, successful stenting of distal biliary strictures ≥ 75 %, physically unassisted in ≥ 80 % of cases; 4) 30-day post-ERCP pancreatitis rates ≤5 %; and 5) satisfactory performance in formative and summative direct observation of procedural skills (DOPS) assessments.
Conclusions JAG certification in ERCP has been developed following evidence-based consensus to quality assure training and to ultimately improve future standards of ERCP practice.