bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anthropogenic Influence on the Diurnal Temperature Range since 1901
Authors: Lu Chunhui , Sun Ying , Zhang Xuebin 
Published: October 2022

Abstract
The diurnal temperature range (DTR) as measured by the difference between daily maximum (Tmax) and minimum (Tmin) temperatures is of great importance to human health, ecology, and agriculture. The link of its long-term change to anthropogenic forcing is still unclear. This study shows evidence of human influence on long-term changes in DTR over the globe, five continents, and China during the past century (1901–2014). Using multiple observational datasets, we find a general decrease in the DTR over most of the global land since 1901, especially after the mid-1950s. Changes in DTR are due to different warming rates of Tmax and Tmin in response to external forcings. The climate models that participated in phase 6 of the Coupled Model Intercomparison Project Phase 6 (CMIP6) generally reproduce most of the changes in DTR, along with those in Tmax and Tmin. The models have underestimated the observed changes in DTR, however. A formal detection and attribution analysis shows that the anthropogenic forcing signal, including both greenhouse gas and aerosol emissions but dominated by the greenhouse gas emissions, is the main driver for these changes. The anthropogenic aerosol signal can be detected in Tmax and Tmin but not in DTR during the period of 1901–2014 over the globe and most continents. These indicate the observed decrease in DTR is not a simple response to anthropogenic aerosol emission. The natural signal is negligible in almost all the cases. Globally, anthropogenic influence is estimated to explain more than 90% of the observed changes in the three variables. In China, human influence is also clearly detected, although model simulated results on the regional scale have larger deviation.

Significance Statement
The diurnal temperature range (DTR) is of great importance in many areas. We compare multiple observational datasets with the simulations by climate models that participated in the latest phase (phase 6) of the Coupled Model Intercomparison Project (CMIP6), finding evidence of human influence on long-term changes in DTR over the past century (1901–2014) and robust evidence for the period since the early 1950s. The decrease in DTR as seen in the observational dataset is caused by different warming rates of daily maximum and daily minimum temperature in response to anthropogenic forcing, including both greenhouse gases and aerosols.
Modulation of Upper Ocean Vertical Temperature Structure and Heat Content by a Fast-Moving Tropical Cyclone
Authors: Zhang Han 
Published: October 2022

Abstract
The ocean temperature response to tropical cyclones (TCs) is important for TC development, local air–sea interactions, and the global air–sea heat budget and transport. The modulation of the upper ocean vertical temperature structure after a fast-moving TC was studied at the observation stations in the northern South China Sea, including TCs Kalmaegi (2014), Rammasun (2014), Sarika (2016), and Haima (2016). The upper ocean temperature and heat response to the TCs mainly depended on the combined effect of mixing and vertical advection. Mixing cooled the sea surface and warmed the subsurface, while upwelling (downwelling) reduced (increased) the subsurface warm anomaly and cooled (warmed) the deeper ocean. An ideal parameterization that depends on only the nondimensional mixing depth (HE), nondimensional transition layer thickness (HT), and nondimensional upwelling depth (HU) was able to roughly reproduce sea surface temperature (SST) and upper ocean heat change. After TCs, the subsurface heat anomalies moved into the deeper ocean. The air–sea surface heat flux contributed little to the upper ocean temperature anomaly during the TC forcing stage and did not recover the surface ocean back to pre-TC conditions more than one and a half months after the TC. This work shows how upper ocean temperature and heat content varies by a TC, indicating that TC-induced mixing modulates the warm surface water into the subsurface, and TC-induced advection further modulates the warm water into the deeper ocean and influences the ocean heat budget.

Significance Statement
Tropical cyclones can cause a strong ocean response that modulates the upper ocean temperature structure and contributes to the local heat budget and transport. This manuscript shows how mixing and vertical advection modulate upper ocean temperature after four fast-moving tropical cyclones, and then gives a parameterization of how sea surface temperature and upper ocean heat change depend on the two mechanisms. The temperature anomalies can propagate into deeper ocean after the tropical cyclones, and sea surface heat flux is not important for upper ocean temperature response during a tropical cyclone. These results show how the upper ocean temperature responses to a tropical cyclone, and influences the local heat budget.
Mayoral Control and School Superintendents: Lessons from Japan
Authors: Aoki Eiichi , Henig Jeffrey R. 
Published: October 2022

Background/Context: Since the early 1990s, the United States has been witnessing reforms in large, high-visibility cities, with mayors granted the power to appoint school boards, superintendents, or both. This shift away from elected school board governance has been characterized as marginalizing traditional educators and ushering in reforms that traditional educators oppose. On the other hand, Japan’s experience with mayoral control of schools is nationwide and longer-lived. In 1956, mayors were given authority to appoint members of the school board, and in 2015 they were given further authority to appoint school superintendents. Purpose/Objective/Research Question/Focus of Study: This study analyzes whether Japanese mayors appoint superintendents whose backgrounds make them likely to challenge the education establishment and introduce dramatic educational reforms. We provide some early evidence on how mayors have been using their new powers and how they interact with the superintendents they select. Research Design: We used data from nationwide surveys conducted by the Japanese government to map the broad pattern of superintendent characteristics over time as well as for a sampling framework to identify and select a smaller number of superintendents to be interviewed for obtaining in-depth information. Semistructured interviews of six superintendents were conducted to delve more deeply into the relationship between mayors and superintendents, and the communication between the superintendents and the school board members in Japan. To triangulate the interview data, transcripts of school board meetings, city council meetings, election bulletins (official campaign manifestos), demographic data, and national test scores of students were collected from 2015 to 2019. Conclusions/Recommendations: We identified important differences between the United States and Japan. Rather than aligning with the reform-oriented mayors against school boards and education bureaucracies, the Japanese mayor-appointed superintendents act as mediators between the mayors and the school boards. The difference may be that, in the United States, only mayors who sought mayoral control had the right to appoint school superintendents, whereas in Japan the national government gave all mayors the right to appoint superintendents, regardless of the political context.
Role of Cognitive Control in Psychotherapy: An Integrated Review
Authors: Kashyap Himani , Mehta Urvakhsh Meherwan , Reddy Rajakumari P. , Bharath Rose Dawn 
Published: October 2022

Background: Cognitive control (CC), including shifting, updating, and inhibiting functions, may play an integral role in various aspects of psychotherapy; however, research on this is limited. This review aims to link the disparate lines of evidence on CC as they relate to psychotherapy processes, techniques, and outcomes. Methods: A systematic search of the literature on neuropsychological domains relating to psychotherapy in adults with anxiety/depression yielded 18 eligible studies. The review also uses a narrative format to explore other potential links between CC and psychotherapy that are underinvestigated, and highlights the need for research and application to evidence-based practice of psychotherapy. Results and conclusions: Findings suggest that CC may predict psychotherapy outcomes and also improve as a function of psychotherapy. Analog sample studies suggest a possible link between CC and techniques for regulation of cognition and emotion, such as reappraisal, mindfulness, and cognitive restructuring. CC may also play an integral role in the regulation of behavior. Study of CC in the context of psychotherapy may potentially explain individual differences in psychotherapy outcomes and mechanisms of action of various psychotherapy techniques and processes. Such an understanding may have possible implications for “best fit” matching clients to therapies and modifying psychological interventions to account for poorer CC abilities. CC may be enhanced through training and further research is warranted on the impact of such training in facilitating better long-term psychotherapy outcomes.
Race and ethnicity moderate the associations between lifetime psychedelic use (MDMA/ecstasy and psilocybin) and major depressive episodes
Authors: Jones Grant M 
Published: October 2022

Background: Psychedelics are receiving renewed attention within Western medicine as they represent potential treatments for many difficult-to-treat mental health disorders. However, psychedelic science is limited in its focus and inclusion of racial and ethnic minorities. Hence, this study examines whether race and ethnicity moderate the associations that naturalistic 3,4-methylenedioxymethamphetamine (MDMA)/ecstasy use and psilocybin use share with major depressive episodes (MDEs). Method: Data for this project are from The National Survey on Drug Use and Health (2005–2019). Participants were adults aged 18 years and older (unweighted N  = 596,187). This study used multivariable logistic regression to test the interaction between race and ethnicity and MDMA/ecstasy use and psilocybin use for predicting lifetime, past year, and past year severe MDEs. Results: Race and ethnicity significantly moderated the associations between MDMA/ecstasy use and psilocybin use and MDEs. For White participants, MDMA/ecstasy use and psilocybin use each were associated with lowered odds of all three MDE outcomes (adjusted odds ratio (aOR) range: 0.82–0.92). For Hispanic participants, MDMA/ecstasy use and psilocybin use each conferred lowered odds of only a past year MDE (MDMA/ecstasy aOR: 0.82; psilocybin aOR: 0.79). For Non-Hispanic Racial Minority participants, MDMA/ecstasy and psilocybin use did not confer lowered odds of any MDE outcomes. Conclusion: Race and ethnicity have an impact on the associations that psychedelics share with mental health outcomes. Future research should explore the impact of identity and discrimination on the effects of psychedelics and should explore whether these substances can serve as effective treatments for minorities when used in culturally informed contexts.
Blended Survival Curves: A New Approach to Extrapolation for Time-to-Event Outcomes from Clinical Trials in Health Technology Assessment
Authors: Che Zhaojing , Green Nathan , Baio Gianluca 
Published: October 2022

Background Survival extrapolation is essential in cost-effectiveness analysis to quantify the lifetime survival benefit associated with a new intervention, due to the restricted duration of randomized controlled trials (RCTs). Current approaches of extrapolation often assume that the treatment effect observed in the trial can continue indefinitely, which is unrealistic and may have a huge impact on decisions for resource allocation. Objective We introduce a novel methodology as a possible solution to alleviate the problem of survival extrapolation with heavily censored data from clinical trials. Method The main idea is to mix a flexible model (e.g., Cox semiparametric) to fit as well as possible the observed data and a parametric model encoding assumptions on the expected behavior of underlying long-term survival. The two are “blended” into a single survival curve that is identical with the Cox model over the range of observed times and gradually approaching the parametric model over the extrapolation period based on a weight function. The weight function regulates the way two survival curves are blended, determining how the internal and external sources contribute to the estimated survival over time. Results A 4-y follow-up RCT of rituximab in combination with fludarabine and cyclophosphamide versus fludarabine and cyclophosphamide alone for the first-line treatment of chronic lymphocytic leukemia is used to illustrate the method. Conclusion Long-term extrapolation from immature trial data may lead to significantly different estimates with various modelling assumptions. The blending approach provides sufficient flexibility, allowing a wide range of plausible scenarios to be considered as well as the inclusion of external information, based, for example, on hard data or expert opinion. Both internal and external validity can be carefully examined. Highlights Interim analyses of trials with limited follow-up are often subject to high degrees of administrative censoring, which may result in implausible long-term extrapolations using standard approaches. In this article, we present an innovative methodology based on “blending” survival curves to relax the traditional proportional hazard assumption and simultaneously incorporate external information to guide the extrapolation. The blended method provides a simple and powerful framework to allow a careful consideration of a wide range of plausible scenarios, accounting for model fit to the short-term data as well as the plausibility of long-term extrapolations.
A collision of strategic orientations: Entrepreneurial orientation and customer relationship orientation in a collectivist cultural context
Authors: Ngo Liem Viet , Shinkle George A , Patterson Paul G 
Published: October 2022

Drawing upon strategic orientation logics and culture theory, this article proposes that entrepreneurial orientation and customer relationship orientation are generally complementary but become conflictual at high levels due to the organizational response to the practices these orientations invoke in a collectivist cultural context. We test this hypothesis with survey data of 146 firms. We find an increasing-return effect of customer relationship orientation on firm performance. Results also reveal a shape-flip phenomenon that when entrepreneurial orientation is low, customer relationship orientation has a J-shape (increasing returns) relationship with firm performance; however, when entrepreneurial orientation is high, customer relationship orientation has an inverted U-shape relationship. JEL Classification: M3 Marketing and Advertising
A software-assisted untargeted liquid chromatography–mass spectrometry method for lipidomic profiling of human plasma samples
Authors: Segrado Francesco , Cavalleri Adalberto , Cantalupi Alice , Mariani Luigi , Dagnino Sonia , Krogh Vittorio , Venturelli Elisabetta , Agnoli Claudia 
Published: October 2022

Introduction In this paper, an analytical pipeline designed for untargeted lipidomic profiling in human plasma is proposed. The analytical pipeline was developed for case-control studies nested in prospective cohorts. Methods The procedure consisted of isopropanol protein precipitation followed by reverse phase liquid chromatography coupled to high resolution mass spectrometry and software-assisted data processing. The compounds are putatively annotated by matching experimental mass spectrometry data with spectral library data using LipidSearch software. The lipid profile of a pool of plasma samples from 10 healthy volunteers was detected in both positive and negative polarity modes. The impact of the chosen polarity on the number and quality of the lipid identification has been evaluated. Results More than 1000 lipids from 12 different classes were detected, 1150 in positive mode and 273 in negative mode. Nearly half of them were unambiguously identified by the software in positive mode, and about one-third in negative mode. The method repeatability was assessed on the plasma pool samples by means of variance components analysis. The intra- and inter-assay precision was measured for 10 lipids chosen among the most abundant found within the different lipid classes. The intra-assay coefficients of variation ranged from 2.56% to 4.56% while intra- and inter-day coefficients of variance never exceeded the 15% benchmark adopted. The lipidomic profiles of the 10 healthy volunteers were also investigated. Discussion This method detects a wide range of lipids and reports their degree of identification. It is particularly fit and well-designed for large case-control epidemiologic studies.
NICU nurses' moral distress surrounding the deaths of infants
Authors: Han Soojeong , Min Haeyoung , Kim Sujeong 
Published: October 2022

Background As Korean neonatal nurses frequently experience the deaths of infants, moral distress occurs when they provide end-of-life care to the infants and their families. Although they need to care for the patients’ deaths and consequently experience burnout and turnover due to moral distress from the situation, there is a lack of a support for nurses. Moreover, not much information is available on the moral distress of neonatal nurses. There is a need to better understand Korean neonatal nurses’ moral distress to develop and implement appropriate supports. Objective This study aimed to describe nurses’ experience of moral distress when they provide end-of-life care to infants and their families in neonatal intensive care units. Research design This is a secondary analysis qualitative study. Content analysis was performed based on Corley’s theory of moral distress to develop a codebook and identify themes regarding moral distress among the nurses. Participants and research context Qualitative data were collected from 20 nurses working in two NICUs in Seoul, South Korea. Ethical considerations The original study obtained permission from a university’s institutional review board (IRB). This secondary analysis study obtained the exemption from another university’s IRB. Nurses’ participation was voluntary and confidential. Findings The nurses’ moral distress was derived when they faced moral constraints and/or moral conflicts. Two distinct categories of moral constraints and four distinct categories of moral conflicts were identified among the neonatal nurses. In addition, impacts of moral distress on patients and nurses were identified. Conclusions This study identified occasions neonatal nurses experience moral distress, and thus can guide in developing and implementing effective interventions to decrease their moral distress and improve their resilience in end-of-life care by providing insight into neonatal nurses’ needs for support in end-of-life care.
Evaluation of Bleeding in Orthopedic Surgery With Perioperative Use of Serotonergic Antidepressants
Authors: Yang Soon H. , Seifert Charles F. 
Published: October 2022

Background: The use of serotonergic antidepressants (SADs) is associated with an increase in bleeding, and their exposure during the perioperative period increases the potential bleeding risk in patients undergoing surgical operations. Objective: The purpose of this study was to compare the rates of bleeding between patients on perioperative SADs and those not on SADs in patients undergoing orthopedic surgical procedures. Methods: A retrospective cohort study was conducted with patients who were admitted to a single tertiary care county teaching hospital for orthopedic surgery. Outcomes evaluated were requirements of ≥ 2 units of packed red blood cells (PRBCs) and length of hospital stay for those requiring ≥ 2 units of PRBCs. Results: Of 273 patients, a significantly higher percentage of patients who received SADs required ≥ 2 units of PRBCs (19.3% vs 6.9%; P = 0.0049). Patients who required transfusion had a higher median (interquartile range [IQR]) age (79 [64-84.6] vs 65 [59-75]; P < 0.0001). The risk of requiring ≥ 2 units of PRBCs transfusion was greater for individuals having an anemia comorbidity (odds ratio [OR], 4.55; 95% CI, 1.95-10.62, P = 0.0004). Patients who required ≥ 2 units of PRBCs had a longer median hospital stay than those who did not receive ≥ 2 units of PRBCs (8 [5-10.1] vs 4 [3-5]; P < 0.0001). Conclusion and Relevance: Receiving SADs in the perioperative period is associated with a higher transfusion requirement in patients undergoing orthopedic surgery. Clinicians should be aware of this increased risk for patients who are taking SADs while undergoing surgical procedures.
A posterior chamber phakic refractive lens dislocated into the vitreous
Authors: Ma Mingming , Xiao Qirui , Wang Aijun , Zheng Zhi 
Published: October 2022

Significance We present a unique cause for zonular dehiscence, which provides a pathway for subsequent dislocation of an implanted phakic refractive lens (PRL) into the vitreous cavity. Purpose To determine the cause of zonular dehiscence and to avoid similar complications after PRL implantation in the future. Case Report A 37-year-old highly myopic patient with refraction of −24.0 DS in both eyes received PRL implantation in both eyes. In the 14-month postoperative follow-up, it was found that the PRL dislocated into the vitreous cavity. The patient then underwent phacoemulsification and vitrectomy. The patient was treated successfully. No ocular complication was found. The visual acuity of the left eye was 20/40, two weeks after surgery. Conclusions We report a unique cause for zonular dehiscence, and the clarification of its detailed characteristics may contribute to prevention of such a complication in the future.
Evaluation of Some Chemical Parameters of Hemodialysis Water: A Case Study in Iran
Authors: Naderi Babak , Attar Hossein Movahedian , Mohammadi Farzaneh 
Published: October 2022

Background: One of the most common diseases in the world is kidney failure, which can lead to the death of patients. Hemodialysis is a treatment for patients whose kidneys are failing. The water used to perform dialysis must be healthy, safe, and clean. This study aimed to investigate the concentration of heavy metals in hemodialysis water in one of the Hospitals in Iran and compare it with European Pharmacopeia (EPH) and Association for the Advancement of Medical Instrumentation (AAMI) standards. Methods: The present study is a descriptive-analytical study conducted on the inlet water of hemodialysis machines in hospital. The samples were collected for 3 months from June to September 2021, Which was examined in terms of free residual chlorine, electrical conductivity, pH, and calcium, magnesium, sodium, aluminum, zinc, copper, and lead concentration. Metals concentration in hemodialysis water was measured by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) technique. Results: The average value of parameters such as electrical conductivity, pH, residual free chlorine, sodium, calcium, magnesium, zinc, copper and lead in the hemodialysis water was less than the AAMI and EPH standards limits. There was a significant difference at the 95% confidence level with the standard limits, but the aluminum concentration was higher than the standard limits. Also, by examining the medical files of dialysis patients, the most observed problems were anemia and bone diseases, which are probably caused by exposure to high concentrations of aluminum in hemodialysis water. Conclusion: In present study the aluminum concentration is higher than the standard limits. Considering that the higher aluminum concentration can cause diseases such as anemia, bone diseases, nervous deterioration, and death in hemodialysis patients, therefore, it is recommended to continuously evaluate and monitor the quality of hemodialysis water and the performance of its treatment system.