bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomic Factors Associated With Osteochondral Allograft Matching for Trochlear Cartilage Defects: A Computer-Simulation Study
Authors: Dandu Navya , Horner Nolan S. , Trasolini Nicholas A. , Hevesi Mario , Cregar William M. , Inoue Nozomu , Yanke Adam B. 
Published: September 2022

Background: Articular step-off between the donor and recipient in osteochondral allograft transplant has been shown to alter contact pressures. Currently, commercial allograft donor selection is primarily based on simple anatomic parameters such as trochlear length, trochlear width, and tibial width. Purpose: To identify anatomic factors associated with optimal graft matching by using a 3-dimensional simulation model. Study Design: Descriptive laboratory study. Methods: Computed tomography images of 10 cadaveric trochlear specimens were obtained to generate 3-dimensional models. Circular defects were created virtually in the recipient trochleae at both superolateral (18.0 mm and 22.5 mm) and central (18.0 mm, 22.5 mm, 30.0 mm) locations. The donor models were virtually projected onto the defect models, and the most optimal graft from any location of the donor specimen was selected. Cartilage incongruity, subchondral bone incongruity, and peripheral articular step-off were calculated for each graft-defect combination. Linear regression models were generated to identify predictors of incongruity, step-off, and the effect of sulcus and sagittal angle mismatch. Akaike information criterion–driven stepwise regression models were generated to identify multivariate predictors. Results: Ideal matches were found for 100% of superolateral defects but for only 15% to 53% of central defects, depending on the defect size. Multivariate stepwise regression identified laterality (odds ratio [OR], 0.54; P = .081), sulcus angle (OR, 0.79; P < .001), sagittal angle (OR, 0.83; P = .001), lateral radius of curvature (OR, 0.81; P < .001), and medial facet width (OR, 0.86; P = .155) as predictors of ideal graft matching. In central defects with proud grafts, increasing sagittal angle and sulcus angle resulted in significantly ( P < .001) increased articular step-off, which became sequentially larger with defect size. Conclusion: Sagittal angle, sulcus angle, and lateral radius of curvature mismatch should be used to determine optimal donor allografts, especially in the setting of large (30-mm) central defects. Increasing sulcus angle and sagittal angle mismatch correlated with increasing step-off in proud grafts, whereas sulcus angle and sagittal angle inconsistently correlated with step-off in recessed grafts. Clinical Relevance: Additional descriptive trochlear measurements should be incorporated into the algorithm for donor selection. These findings can be used to identify acceptable mismatch parameters.
External Validation of a Machine Learning Algorithm for Predicting Clinically Meaningful Functional Improvement After Arthroscopic Hip Preservation Surgery
Authors: Kunze Kyle N. , Kaidi Austin , Madjarova Sophia , Polce Evan M. , Ranawat Anil S. , Nawabi Danyal H. , Kelly Bryan T. , Nho Shane J. , Nwachukwu Benedict U. 
Published: September 2022

Background: Individualized risk prediction has become possible with machine learning (ML), which may have important implications in enhancing clinical decision making. We previously developed an ML algorithm to predict propensity for clinically meaningful outcome improvement after hip arthroscopy for femoroacetabular impingement syndrome. External validity of prognostic models is critical to determine generalizability, although it is rarely performed. Purpose: To assess the external validity of an ML algorithm for predicting clinically meaningful improvement after hip arthroscopy. Study Design: Cohort study; Level of evidence, 3. Methods: An independent hip preservation registry at a tertiary academic medical center was queried for consecutive patients/athletes who underwent hip arthroscopy for femoroacetabular impingement syndrome between 2015 and 2017. By assuming a minimal clinically important difference (MCID) outcome/event proportion of 75% based on the original study, a minimum sample of 132 patients was required. In total, 154 patients were included. Age, body mass index, alpha angle on anteroposterior pelvic radiographs, Tönnis grade and angle, and preoperative Hip Outcome Score–Sports Subscale were used as model inputs to predict the MCID for the Hip Outcome Score–Sports Subscale 2 years postoperatively. Performance was assessed using identical metrics to the internal validation study and included discrimination, calibration, Brier score, and decision curve analysis. Results: The concordance statistic in the validation cohort was 0.80 (95% CI, 0.71 to 0.87), suggesting good to excellent discrimination. The calibration slope was 1.16 (95% CI, 0.74 to 1.61) and the calibration intercept 0.13 (95% CI, –0.26 to 0.53). The Brier score was 0.15 (95% CI, 0.12 to 0.18). The null model Brier score was 0.20. Decision curve analysis revealed favorable net treatment benefit for patients with use of the algorithm as compared with interventional changes made for all and no patients. Conclusion: The performance of this algorithm in an independent patient population in the northeast region of the United States demonstrated superior discrimination and comparable calibration to that of the derivation cohort. The external validation of this algorithm suggests that it is a reliable method to predict propensity for clinically meaningful improvement after hip arthroscopy and is an essential step forward toward introducing initial use in clinical practice. Potential uses include integration into electronic medical records for automated prediction, enhanced shared decision making, and more informed allocation of resources to optimize patient outcomes.
Neuropsychiatric manifestations are associated with increased mortality in Indian patients with lupus: A single centre retrospective observational study
Authors: Pinto Benzeeta , Suresh Sumatha C , Ramyasri Kodali , Narayan Girish , Susan Deepa , Manuel Sandra , Wodeyar Aishwarya , Shivanna Archana , Janardana Ramya , Chanakya Kodishala , Charles B Sheba , Nanjundaswamy Sangeetha K , Desai Anu M , Nadig Raghunandan , Shobha Vineeta 
Published: September 2022

Objective To study the prevalence of different NPSLE manifestations in our cohort and to compare clinical and immunological features and outcomes including mortality of patients with NPSLE and SLE controls without NP involvement. Methods This was a retrospective study in a tertiary care referral centre. All patients of SLE seen in the last 10 years and fulfilling the SLICC criteria with neuropsychiatric manifestations as per the ACR definitions were included. Patients of SLE without NP involvement were sequentially assigned as controls in a ratio of 1:2. Results Of the 769 patients diagnosed with SLE from Jan 2011 to December 2020, 128 (16.6%) had NPSLE manifestations as per the ACR definitions. The commonest NPSLE manifestation was seizures (6.5%) followed by cerebrovascular accident (3.9%). NPSLE manifestation occurred at the first presentation of SLE in 99/128 (77.3%) patients and 58 (45.3%) patients had more than one NPSLE manifestation. Lupus anticoagulant and anticardiolipin antibody were tested in 120 patients and were positive in 16 (13.3%) and 12 (10%), respectively. No difference was found in anti-ribosomal p, lupus anticoagulant and anticardiolipin antibodies between the cases and controls. Twenty-one (16.4%) deaths occurred in patients with NPSLE (median follow-up of 40 months) as compared to 13 (5%) in controls (median follow-up of 32 months) ( p = <0.001). The cumulative survival of patients with NPSLE was lower as compared to controls ( p < 0.001). Relapse of NPSLE was seen in 11(8.6%) patients and was associated with mortality ( p = 0.017). Conclusions Seizures and cerebrovascular accidents are the commonest NPSLE syndromes in our patients. The presence of NPSLE was associated with high mortality in Indian patients with lupus.
Autotaxin is a potential link between genetic risk factors and immunological disturbances of plasmacytoid dendritic cells in systematic lupus erythematosus
Authors: Tsuchida Yumi , Shoda Hirofumi , Nakano Masahiro , Ota Mineto , Okamura Tomohisa , Yamamoto Kazuhiko , Kurano Makoto , Yatomi Yutaka , Fujio Keishi , Sawada Tetsuji 
Published: September 2022

Background The importance of autotaxin, an enzyme that catalyzes lysophospholipid production, has recently been recognized in various diseases, including cancer and autoimmune diseases. Herein, we examined the role of autotaxin in systemic lupus erythematosus (SLE), utilizing data from ImmuNexUT, a comprehensive database consisting of transcriptome data and expression quantitative trait locus (eQTL) data of immune cells from patients with immune-mediated disorders. Methods Serum autotaxin concentrations in patients with SLE and healthy controls (HCs) were compared. The transcriptome data of patients with SLE and age- and sex-matched HCs were obtained from ImmuNexUT. The expression of ENPP2, the gene encoding autotaxin, was examined in peripheral blood immune cells. Next, weighted gene correlation network analysis (WGCNA) was performed to identify genes with expression patterns similar to ENPP2. The ImmuNexUT eQTL database and public epigenomic databases were used to infer the relationship between autotaxin and pathogenesis of SLE. Results Autotaxin levels were elevated in the serum of patients with SLE compared to HCs. Furthermore, the expression of ENPP2 was higher in plasmacytoid dendritic cells (pDCs) than in other immune cell subsets, and its expression was elevated in pDCs of patients with SLE compared to HCs. In WGCNA, ENPP2 belonged to a module that correlated with disease activity. This module was enriched in interferon-associated genes and included genes whose expression was influenced by single-nucleotide polymorphisms associated with SLE, suggesting that it is a key module connecting genetic risk factors of SLE with disease pathogenesis. Analysis utilizing the ImmuNexUT eQTL database and public epigenomic databases suggested that the increased expression of ENPP2 in pDCs from patients with SLE may be caused by increased expression of interferon-associated genes and increased binding of STAT3 complexes to the regulatory region of ENPP2. Conclusions Autotaxin may play a critical role in connecting genetic risk factors of SLE to disease pathogenesis in pDCs.
Oct biomarkers of treatment-naive diabetic macular edema in patients with non-proliferative and proliferative diabetic retinopathy
Authors: Turkseven Kumral Esra , Ercalık Nimet Yesim , Alpogan Oksan , Yenerel Nursal Melda , Ozcelik Kose Alev , Ozturk Yucel , Acar Zeynep Ayse 
Published: September 2022

Purpose To evaluate and compare the retinal and choroidal spectral-domain optic coherence tomography (SD-OCT) findings of treatment-naïve diabetic macular edema (DME) secondary to non-proliferative and proliferative diabetic retinopathy (NPDR-PDR). Material and methods A hundred and thirty-eight eyes of 138 patients with DME were evaluated. Best-corrected visual acuity was recorded, biomicroscopic anterior and posterior segment examination, SD-OCT imaging, and fundus fluorescein angiography (FFA) were performed. Demographic features, OCT characteristics, FFA, and visual acuity measurements were evaluated and compared between the two groups. Results Sixteen eyes were excluded from the study due to the lack of FFA images. Data of 122 eyes were analyzed for the study. Sixty-five eyes with NPDR (Group 1) and 57 eyes with PDR (Group 2) were enrolled in the study. There was no significant difference in central macular thicknesses (CMT) between the two groups. The eyes with DME + PDR showed a higher rate of the diffuse type of macular edema with more para and peri-foveal extension accompanied by larger cysts than the eyes with DME + NPDR. Disorganization of retinal inner layers, disrupted ellipsoid zone, and the epiretinal membrane were more prominent in the eyes with PDR. Also, there were more prominent macular ischemia on FFA and worse initial visual acuity measurements in the eyes with PDR than those with NPDR. Choroidal thickness (CT) was significantly reduced in the PDR group. Conclusion SD-OCT features of treatment-naïve DME in patients with NPDR and PDR presented some differences. These variations may be related to diabetic retinopathy severity and may provide information about prognosis.
Rituximab Treatment of Primary Cutaneous Follicle Center Lymphoma: A Retrospective Review
Authors: Wang Siru , Perlmutter Jonah W. , Johnston James , Nugent Zoann , Wiseman Marni 
Published: September 2022

Background Primary cutaneous B-cell lymphoma (PCBCL) presents only in the skin at the time of diagnosis with no evidence of extracutaneous disease, and primary cutaneous follicle center lymphoma (PCFCL) is the most common subtype. There is currently a lack of prospective randomized control trials and large retrospective studies investigating the efficacy of different treatment options for PCFCL. This retrospective study was conducted to describe our local clinical experience and outcomes of patients treated with rituximab-containing regimens. Objectives To describe our local clinical experience and treatment outcomes of patients treated with rituximab-containing regimens. Methods A retrospective study consisting of 25 PCFCL patients treated with different modalities. Patient records were reviewed and analyzed using a Kaplan-Meier estimation and SAS 9.4 software. Results After the initial treatment, all patients had CR except for 1 patient in the observation group. Further, 60% of patients in surgery, 20% in chemoimmunotherapy, 67% in rituximab monotherapy, 33% in steroid injection/systemic prednisone, and 33% in observation experienced a relapse. Although no significant difference was found between treatment groups due to the small sample size, time to relapse trends provides insight into treatment responses. Chemoimmunotherapy had the lowest relapse rate in the first 5 years post-treatment, whereas surgery had a higher tendency to relapse. Conclusions Despite the potential for rituximab-containing chemoimmunotherapy to yield adverse effects, it is effective in achieving a prolonged clinical remission in patients with PCFCL. It remains a reasonable treatment option for diffuse, extensive, or treatment-resistant disease.
Teleneuropsycological adaptation of the NEUROPSI Breve screening test
Authors: González-Osornio María Guadalupe , Medina-Rivera Martha Valeria , Orta-Castañeda Larissa 
Published: September 2022

Objective Teleneuropsychology refers to the application of neuropsychology using video teleconferencing (VTC) techniques, whose methodology facilitates access to remote populations, a need that has increased due to the COVID-19 pandemic. Numerous investigations have documented the equivalence of different screening assessments (Mini Mental State Examination, Montreal Cognitive Assessment (MoCA) test and the Repeatable Battery for the Assessment for Neuropsychological Status) when applied via teleneuropsychology. The goal of the present work is to test the equivalence of the Brief Neuropsychological Battery in Spanish (NEUROPSI Breve), a neuropsychological screening instrument standardized for Spanish-speaking population that has reported a high sensitivity (91.6%) for identifying dementia, when applied in the VTC modality. Method In total, 32 Mexicans between 16 and 70 years were assessed, both in traditional (face-to-face) and VTC format with a 20 min wait between each application. Each participant was randomly assigned into one of four groups that were generated from the established conditions: the first application could be face-to-face or by VTC modality and an adapted or original version of NEUROPSI Breve would be applied; for the second application, the remaining modality and instrument would be used. Statistical analysis was carried out using the IBM Statistical Package for the Social Sciences (SPSS) software (v. 25). Results The Wilcoxon signed-rank test presented statistically significant differences (Z = −2.79, P = .005). However, when applied to each one of the four evaluation groups, the Wilcoxon signed-rank test showed no statistically significant differences; the same results were found when starting with the original or adapted instrument, and when starting with the face-to-face modality ( P < .005). However, differences are shown when starting with the online (VTC) modality (groups B and C) ( P = .028). Conclusions The NEUROPSI Breve is applicable in both modalities, satisfying the needs of the population and the evaluation guidelines.
Living in uncertainty while a spouse is undergoing a cognitive assessment: Voices of women care partners
Authors: Hedman Ragnhild , Hillerås Pernilla , Tyrrell Marie 
Published: September 2022

Introduction Women often support partners with cognitive symptoms during the assessment process and when they are receiving a cognitive diagnosis. Living with a partner with cognitive symptoms can be stressful; however, there is limited insights into the specific experiences of older women during the assessment process. Previous research indicates that there are gender differences in the experiences of spousal caregiving; however, further research is needed in regard to the experiences of men and women as care partners. Therefore, the aim of the present study was to describe women’s experiences of living with a partner undergoing a cognitive assessment. Methods Semi-structured interviews were conducted with seven women when their male partners commenced a cognitive assessment and after the assessment had been completed. The interviews were analysed with abductive content analysis. Findings Uncertainty permeated the women’s experiences. Antecedents, attributes and strategies to manage the uncertainty were described. Conclusion The participants expressed informational and existential uncertainty when their partner underwent a cognitive assessment. A lack of knowledge regarding the assessment process and cognitive diagnoses, especially mild cognitive impairment, was identified. Further, there was a need to process existential uncertainty evoked by the situation.
Exploring Countermarketing Messages to Reduce Youth Sugar-Sweetened Beverage Consumption in The Bronx, NY
Authors: Palmedo P. Christopher , Flores Samantha , Castillo Kalya , Byrne-Zaaloff Moria , Moltzen Kelly 
Published: September 2022

Background Racial and ethnic targeted marketing of junk foods, particularly sugar sweetened beverages (SSBs), is a health concern for communities already disproportionately suffering from obesity, diabetes, and heart disease. Focus of the Article The article is a report on qualitative research which explored attitudes and message testing intended to dissuade youth from drinking SSBs. Research Question Can the incorporation of countermarketing messages improve the effectiveness of a curriculum and/or social marketing campaign to reduce SSB consumption among youth in The Bronx, NY? Design and Approach Eight focus groups ( N = 66) with youth 12–15 to explore ideas and messages to reduce SSB consumption. Youth were recruited from a coalition of afterschool programs dedicated to eliminating racial and ethnic health disparities. The focus groups explored product (formulation), price (low), place (ubiquity), and promotion (racial and ethnic targeting), and focused on messages that can be used to counter existing industry messaging. Importance to Social Marketing Countermarketing, a sub-field of social marketing, has been effective in tobacco control, but its effectiveness has been less understood with ultra-processed foods and beverages. We wanted to learn how participants would respond to information about the product manipulation and racial targeted marketing that underlies much of the poor nutritional choices in underserved communities. We were seeking to determine if incorporating this information into a comprehensive social marketing plan could positively influence consumption habits. Methods Eight focus groups with 66 students. The focus group guide was informed by the Theory of Planned Behavior and the literature on youth consumption of SSBs, and employed a semi-structured interview design. Using an inductive modified grounded theory approach, the team identified relevant themes and insights for social marketing practice. Recommendations for Research or Practice The results of this study can assist in the development of a social marketing strategy to reduce SSB consumption among populations targeted by food and beverage companies. The study reinforces prior research that countermarketing messaging may be effective in such a campaign. Potentially effective messaging topics include racial/ethnic targeting, product formulation, and the health effects of processed foods. Limitations While this research project covered messaging and broad strategy, it did not explore specific tactics to activate the concepts discussed in the focus groups. Also, while the study may be considered generalizable to other large cities in the U.S., broader applicability should be met with caution.
WEB embolization of very broad-based intracranial aneurysms with a dome-to-neck ratio ≤ 1.1
Authors: Goertz Lukas , Liebig Thomas , Siebert Eberhard , Pennig Lenhard , Zaeske Charlotte , Celik Erkan , Schlamann Marc , Dorn Franziska , Kabbasch Christoph 
Published: September 2022

Objective The Woven EndoBridge (WEB) is a well-studied intrasaccular device for endovascular treatment of wide-necked bifurcation aneurysms. We evaluated the feasibility, safety and efficacy of the WEB for the treatment of very broad-based aneurysms with a dome-to-neck ratio ≤ 1.1. Methods Thirty-four aneurysms treated at three neurovascular centers were retrospectively identified. The mean aneurysm size was 5.5 ± 1.6 mm with a mean neck width of 4.7 ± 1.5 and a mean dome-to-neck ratio of 1.0 ± 0.1. The primary outcome measures were immediate technical treatment success by WEB only, complete or near-complete occlusion at 6-month follow-up and ischemic stroke. Results Aneurysm embolization by WEB only was technically feasible in 79.4%. Additional stenting was required in 14.7%. In two aneurysms (5.9%), WEB implantation failed, and the aneurysm was treated by stent- and balloon-assisted coiling, respectively. Thromboembolic events occurred during 5 interventions (14.7%), all of these performed in ruptured aneurysms. One patient (2.9%) remained asymptomatic (follow-up modified Rankin scale [mRS] score: 0), 2 patients (5.9%) had a transient deficit (mRS 0 and 1, respectively), and 2 (5.9%) had a disabling ischemic stroke (mRS 3, respectively). Mid-term angiographic follow-up of 29 patients (4.0 ± 2.6 months, range: 2–9 months) showed complete occlusion (WEB occlusion scale [WOS] A) in 41.4%, near-complete occlusion (WOS B) in 34.5%, a neck remnant (WOS C) in 10.3%, and aneurysm remnants (WOS D) in 13.8%. Conclusions WEB embolization of very broad-necked aneurysms was technically feasible and could be achieved by WEB only in the majority of cases. Considering the challenging anatomy of very broad-based aneurysms, the WEB procedure was reasonably safe and efficient.