bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of ginseng oral administration and ginseng injections on cancer-related fatigue: A meta-analysis
Authors: Li Huijing , Hou Tianwen , Sun Shijiang , Huang Jing , Wang Xueqi , Liang Xi , Zhao Tianhe , Hu Jingnan , Ge Jianli , Bai Haiyan , He Jianming 
Published: November 2022

Background:
Up to 90% of patients who are under the active treatment suffer from cancer-related fatigue (CRF). CRF can persist about 10 years after diagnosis and/or treatment. Accumulating reports support that ginseng and ginseng injections are both potential drugs for the treatment of CRF but few studies put them together for analysis.

Methods:
Two reviewers independently extracted data in 3 databases (PubMed, Cochrane Library and China National Knowledge Infrastructure) from their inception to May 24, 2021. The primary outcome was the effect of ginseng in alleviating CRF. The secondary outcome was ginseng in alleviating emotional or cognitive fatigue. Standardized mean difference (SMD) was employed.

Results:
Twelve studies were included to evaluate efficacy of ginseng oral administration and ginseng injections on CRF. The pooled SMD was 0.40 (95% confidence Interval [95% CI] [0.29–0.51], P < .00001). Six studies were included to evaluate efficacy of ginseng oral administration on CRF and the SMD was 0.29 (95% CI [0.15–0.42], P < .0001). The order was 2000 mg/d, 3000 mg/d, 1000 mg/d and placebo from high efficacy to low. Ten studies were included to evaluate efficacy of ginseng injections on CRF and the SMD was 0.74 (95% CI [0.59–0.90], P < .00001). Emotional fatigue was reported in 4 studies, ginseng oral administration in 2 and ginseng injections in 2. The pooled SMD was 0.12 (95% CI [−0.04 to 0.29], P = .15). Cognitive fatigue was reported in 4 studies focusing on ginseng injections and the SMD was 0.72 (95% CI [0.48–0.96], P < .00001).

Conclusion:
Ginseng can improve CRF. Intravenous injection might be better than oral administration. Ginseng injections may alleviate cognitive fatigue. No evidence was found to support that ginseng could alleviate emotional fatigue.
Pulmonary blastoma that was first diagnosed as dedifferentiated chondrosarcoma using medical thoracoscopy: A case report
Authors: Kim Tae Hun , Jeon Jae Hyun , Chung Jin-Haeng , Cho Young-Jae 
Published: November 2022

Rationale:
Pulmonary blastoma is an extremely rare and highly aggressive tumor. Only a few hundred cases of pulmonary blastoma have been reported. In other cases, a definitive diagnosis is often made through surgical resection. The use of preoperative histopathological sampling in diagnosing was of limited value because of the variety of pulmonary blastoma histology. And there was no literature that the first biopsy was attempted with medical thoracoscopy for diagnosis.

Patient concerns:
A 65-year-old man presented to our hospital with pleural effusion and lung mass.

Diagnoses:
The patient was initially diagnosed with dedifferentiated chondrosarcoma by medical thoracoscopic biopsy but the final diagnosis was pulmonary blastoma through bilobectomy.

Interventions:
Medical thoracoscopy, and video-assisted thoracoscopic surgery (bilobectomy) followed by adjuvant chemotherapy.

Outcomes:
After surgical resection of the tumor, adjuvant chemotherapy has been performed 5 cycles at 3 weeks intervals, and there was no evidence of recurrence on follow-up computed tomography performed 4 months after surgery.

Lessons:
Medical thoracoscopy is useful for the diagnosis of indeterminate pleural effusion; however, caution is needed when confirming rare malignancies, such as pulmonary blastoma. Although surgical resection is the treatment of choice, appropriate adjuvant chemotherapy to improve the prognosis may be necessary if there is pleural metastasis.
Abdominal examination using pressure pain threshold algometer reflecting clinical characteristics of complementary and alternative medicine in Korea: A systematic review and a brief proposal
Authors: Kim Yohwan , Kim Kyuseok 
Published: November 2022

Background:A review was conducted to determine a pressure algometry measurement during abdominal examination that reflects clinical settings of traditional Korean medicine.Methods:After reviewing the previous studies, we have proposed a reference index, common posture and method for performing pressure algometry during abdominal examination. Keyword search using eight databases was performed. To identify the characteristics of pressure algometry during abdominal examination, keywords (e.g., abdomen, abdominal examination) were searched in national Korean databases, including Korean studies Information System (KISS), Research Information Sharing Service (RISS), and Oriental Medicine Advanced Searching Integrated System (OASIS). To examine the methods of measuring pressure pain threshold (PPT) with validity and reliability, combination keywords (e.g., PPT, pressure algometry, pressure pain, validity, reliability) were searched in Pubmed, Cochrane library, Google scholar, Ovid Embase, and China Knowledge Resource Integrated Database (CNKI).Results:A total of 652 articles were identified, and 22 relevant articles were included. The following main indices are proposed as a standardized pressure algometry method during abdominal examination: unit of measurements, measuring tools, target locations, pressure area, pressure rate, posture of patients, and evaluators. Based on the results of the review combined with clinical practice, useful indices for pressure algometer during abdominal examination were derived (target location: CV 12, unit of measurement: MPa, pressure area: 4 cm2, pressure rate: 0.098 MPa/s, posture of patient: supine position, number, and intervals of measurement: three consecutive measurements at intervals of 30 seconds, 5 minutes rest prior to commencement). Postures and method sequence of pressure algometry during abdominal examination are also proposed.Conclusions:Using standardized indices, postures and method for abdominal examination in clinical settings will help make objective assessments.
A clinical guideline-based management of type 2 diabetes by ayurvedic practitioners in Nepal: A feasibility cluster randomized controlled trial protocol
Authors: Chattopadhyay Kaushik , Dhimal Meghnath , Karki Shristi , Regmi Prerok , Bista Bihungum , Biswas Tuhin Kanti , Heinrich Michael , Panniyammakal Jeemon , Tandon Nikhil , Leonardi-Bee Jo , Kinra Sanjay , Greenfield Sheila Margaret , Lewis Sarah Anne , Upadhyay Vasudev , Gyanwali Pradip 
Published: November 2022

Introduction:
Type 2 diabetes mellitus (T2DM) is a common chronic condition with significant health and socioeconomic consequences. In Nepal, T2DM is a common disease for which people consult ayurvedic (traditional medical system) practitioners and use ayurvedic medicines. Strong concerns remain about the suboptimal T2DM management of many patients by ayurvedic practitioners, and therefore, based on the best available scientific evidence, we have developed a clinical guideline for managing T2DM by ayurvedic practitioners. The research question to be addressed by a definitive cluster randomized controlled trial (RCT) is whether the introduction of a clinical guideline can improve the management of T2DM by ayurvedic practitioners in Nepal as compared to usual ayurvedic management (i.e., without any clinical guideline). In preparation for this future work, this current study aims to determine the feasibility of undertaking the definitive cluster RCT.

Methods:
This is a 2-arm, feasibility cluster RCT with a blinded outcome assessment and a qualitative evaluation. The study is conducted in 12 public and private ayurveda centers in and outside the Kathmandu Valley in Nepal (1:1 intervention:control). Eligible participants should be new T2DM adult patients (i.e., treatment naïve) - the glycated hemoglobin level should be 6.5% or above but less than 9%. At least 120 participants (60/group) will be recruited and followed up for 6 months. Important parameters, needed to design the definitive trial, will be estimated, such as the standard deviation of the outcome measure (i.e., glycated hemoglobin level at 6-month follow-up), intraclass correlation coefficient, cluster size, recruitment, the time needed to recruit participants, follow-up, and adherence to the recommended ayurvedic medicine. Semi-structured qualitative interviews will be conducted with around 20 to 30 participants and all the participating ayurvedic practitioners to explore their experiences and perspectives of taking part in the study and of the intervention and a sample of eligible people declining to participate in the study to explore the reasons behind nonparticipation.

Discussion:
We are now conducting a feasibility cluster RCT in Nepal to determine the feasibility of undertaking the definitive cluster trial. The first participant was recruited on 17 July 2022. If the feasibility is promising (such as recruitment, follow-up, and adherence to the recommended ayurvedic medicine), then the parameters estimated will be used to design the definitive cluster trial. Decisions over whether to modify the protocol will mainly be informed by the qualitative data.
A comparative investigator-initiated pilot study on the efficacy and safety of biodegradable microneedle acupuncture and conventional intradermal acupuncture for dry eye patient: A superiority, assessor-blinded, randomized controlled trial
Authors: Song Ji-Hoon , Park Soo-Yeon 
Published: November 2022

Background:
The prevalence of dry eye, which is a common lacrimal disease, is steadily increasing in modern society. However, fundamental treatment for it has not yet been established. This study aims to assess the efficacy and safety of a novel medical device, the biodegradable microneedle acupuncture (BMA), using a traditional intradermal acupuncture needle as the control acupuncture for dry eye.

Method:
This study will be an investigator-initiated, assessor-blinded, comparative, superiority pilot randomized controlled trial. A total of 30 patients with dry eye will be randomly assigned to the experimental or the control group in equal proportion. For the experimental group, the BMA will be applied to both sides of 5 acupoints including BL2, GB14, TE23, EX-HN5, and ST1. For the control group, conventional intradermal acupuncture will be applied to the same acupoints. The needles will be attached for 4 hours. Over 4 weeks, both the interventions will be performed 12 times in total. The primary outcome would be the ocular surface disease index. The secondary outcomes would be the visual analog scale for subjective symptoms, quality of life, Schirmer I test, and general assessment.

Discussion:
The findings of this study on the efficacy and safety of the BMA would be helpful for patients with dry eye in clinical practice. Further, these results would provide for the foundation of a large-scale BMA study.
Effectiveness of Sopoongsan for chronic upper body pruritus in patients with atopic or seborrheic dermatitis: A pilot study protocol for a randomized, double-blind, placebo-controlled, parallel trial
Authors: Jang Jung-Hee , Jun Purumea , Park Gunhyuk , Kwon Ojin , Choi Yujin , Lim Hye-Sun , Moon Byeong Cheol , Kim Kyuseok 
Published: November 2022

Introduction:
Chronic pruritus persists for > 6 weeks and is known to decrease patients’ quality of life. Due to the complex pathological mechanism of chronic pruritus, there is still a lack of satisfactory therapeutic agents; therefore, complementary therapies are required to improve itching symptoms. In the Republic of Korea, Sopoongsan, an herbal formula, has been used to treat itching, dizziness, and skin paralysis. To our knowledge, this is the first study to evaluate whether Sopoongsan improves chronic pruritus and to identify Sopoongsan-related changes in the immune response in patients with chronic upper body pruritus.

Methods:
A randomized, double-blind, placebo-controlled parallel trial will be conducted to assess 20 patients with chronic upper body pruritus for 3 months who have been diagnosed with allergic atopic dermatitis or seborrheic dermatitis. The patients will be randomly allocated to either the placebo-control (n = 10) or treatment (n = 10) group. The total study period will be 8 weeks (i.e., administration of Sopoongsan or placebo drugs for 4 wk and follow-up for 4 wk). Participants will be allowed to receive external treatment, except for antipruritic medications administered orally, throughout the study period. The primary outcome measure will be the numeric rating scale results for itching, whereas the secondary outcome measures will be questionnaire survey (Dermatological Life Quality Index and Epworth Sleepiness Scale) findings and the immune response index, including interferon gamma, interleukin-4, immunoglobulin E, thymic stromal lymphopoietic protein, and histamine, to investigate the biological mechanisms underlying chronic pruritus.

Discussion and Conclusions:
We expect that the results of this study will provide important clinical evidence regarding the effectiveness of Sopoongsan on itching symptoms, quality of life, sleep disturbance, and changes in the immune response. The findings will help elucidate the mechanism underlying the therapeutic effect of Sopoongsan for chronic pruritus and lay the foundation for further studies in this area.
Porridge for influenza: Protocol for a systematic review and meta-analysis
Authors: Sun Haoxiang , Mei Manxue , Xu Jiayu , Chen Xiaofang , Zhu Wei , Song Jianping 
Published: November 2022

Background:
Influenza is a common disease. If it is not treated in time, it may induce related chronic respiratory diseases and seriously endanger people’s health. Porridge, as a food of the East, has been recorded by doctors of all ages to treat influenza with porridge. However, due to insufficient research, there is a certain controversy about porridge in the treatment of influenza. We therefore plan to conduct a systematic review and meta-analysis to collect data from all published studies on this issue in order to obtain reliable evidence.

Method and analysis:
We will search for relevant trials in various databases published by December 2022. To study the efficacy and safety of a RCT of porridge in the treatment of influenza. Standardized data tables will be used to complete data search and extraction in duplicate. All differences will be resolved by consensus. The main result was to observe the symptom score of influenza patients, and the secondary results included body temperature, nasal secretions, nasal resistance and viral culture titers in the nasal secretions. Data synthesis and statistical analysis will be performed for each outcome with Stata V.14.0.

Results:
Our study will be a systematic review and meta-analysis to evaluate the efficacy and safety of porridge in the treatment of influenza.

Conclusion:
The conclusion of this study has a certain reference value for the clinical use of porridge in the treatment of influenza.
Durable response to low-dose pralsetinib in a renal insufficient patient with NSCLC harboring concurrent CCDC6-RET, LINCO1264-RET, and SEMA5A-RET fusions: A case report
Authors: Gu Linping , Ji Wenxiang , Xu Yunhua , Han Yuchen , Jian Hong 
Published: November 2022

Introduction:

RET-rearranged fusions have been considered as oncogenic drivers in 1% to 2% of non-small cell lung cancers (NSCLC). ARROW study has demonstrated a new selective RET tyrosine kinase inhibitors (TKIs) shows remarkable and durable responses in RET-rearranged NCSLC. In this study mainly recruited patients with common fusion partners KIF5B and CCDC6. There is still a lack of definitive conclusions about effective of rare RET fusion variants to anti-RET therapies.

Case report:
A Chinese 58-year-old female renal insufficient patient with no history of smoking was diagnosed as stage IIIA (T2N2M0) lung adenocarcinoma. Next-generation sequencing targeting 520 cancer-related genes was performed on the pleural effusion samples and revealed 2 novel RET fusions LINCO1264-RET and SEMA5A-RET, concomitant with a common CCDC6-RET.

Management and outcome:
The patient was first treated with multiple lines of chemotherapy and switched to lenvatinib but failed to respond. Due to renal insufficiency, she subsequently received pralsetinib with gradually reduced dosages (400 mg-300 mg-200 mg-100 mg qd) and achieved a partial response (PR) lasting for more than 10 months, accompanied by the declined allele frequencies of all 3 RET fusions.

Discussion/conclusions:
We reported the first case of the pralsetinib efficacy in NSCLC with 3 concurrent RET fusions. Our case also indicates the sensitivity of the newly identified RET fusions to this RET selective inhibitor pralsetinib, and highlights the low-dose treatment option for patients with renal insufficient background.
An examination of cyberchondria’s relationship with trait anxiety and psychological well-being in women of reproductive age: A cross-sectional study
Authors: Sezer Önder , Başoğlu Mehmet Akif , Dağdeviren Hamdi Nezih 
Published: November 2022

Online environments have become the main sources of health-related information. However, if used incorrectly, this can decrease the level of well-being. Cyberchondria corresponds to the hypochondria in the digital age. We aimed to investigate the relationship between cyberchondria and trait anxiety, psychological well-being, and other factors in women of reproductive age.
This study used a descriptive cross-sectional design. Face-to-face questionnaires were administered to women aged 18 to 49. The sample size was formed and stratified according to the population of the 47 family health centers to reflect the entire population. The questionnaire included a sociodemographic information form, the Cyberchondria Severity Scale (CSS), the State-Trait Anxiety Inventory, and the Psychological Well-Being Scale (PWBS).
This study included 422 participants. The average daily use of the Internet was 2.14 ± 1.837 hours, while that of social media was 2.69 ± 2.027 hours. The mean CSS score was 89.42 ± 21.688; the mean trait anxiety score was 44.34 ± 8.791, and the mean PWBS score was 324.26 ± 35.944. Factors that interacted with the level of cyberchondria were the trait anxiety score, PWBS score, alcohol consumption, and average daily use of the internet and social media.
Increased online time, alcohol consumption, trait anxiety levels, and psychological well-being increase cyberchondria levels. Improvements must be made in the accuracy of online information, which is unsupervised and easily accessible to society as a source of information. Future studies should focus on the prevention, detection, and treatment of cyberchondriasis. Identifying and improving the factors affecting women’s and mothers’ cyberchondria will also increase the chances of providing primary protection against certain diseases.
Efficacy and safety of Chinese herbal medicine Danggui Sini decoction for knee osteoarthritis: A protocol for systematic review and meta-analysis
Authors: Zhou Xing , Xiang Ke-Meng , Li Jinlei , Yang Guang , Wang Yanbo , Xia Hanting , Zhuang Rujie 
Published: November 2022

Background:
Knee osteoarthritis (KOA) often causes joint pain, weakness and mobility disorders, which seriously affects people’s daily life and makes them unable to work and study normally. Traditional Chinese medicine (TCM) prescription Danggui Sini Decoction (DGSND) has been widely used in clinical practice and achieved good results. But there is no high-level evidence to support this result. The aim of this study is to evaluate DGSND’s efficacy and safety in the management of KOA.

Methods:
We will search 7 electronic databases including Chinese National Knowledge Infrastructure (CNKI), Wanfang Data (WF), Chinese Scientific Journals Database (VIP), Chinese databases SinoMed (CBM), PubMed, Embase, and Cochrane Library databases. All the publications, with no time restrictions, will be searched without any restriction of language and status, the time from the establishment of the database to September 2022. Two reviewers will independently assess the quality of the selected studies, NoteExpress and Excel software will be used to extract data, and the content will be stored in an electronic chart. Different researchers will separately screen the titles and abstracts of records acquired potential eligibility which comes from the electronic databases. Full-text screening and data extraction will be conducted afterward independently. Statistical analysis will be conducted using RevMan 5.4 software.

Results:
This study will compare the effects of DGSND and any other different methods on patients with KOA to provide high-quality, evidence-based clinical recommendations.

Conclusion:
The study provides a trustable clinical foundation for DGSND in the treatment of KOA.
Lung ultrasound for the diagnosis of pulmonary atelectasis in both adults and pediatrics: A protocol for systematic review and meta-analysis
Authors: Liu Wenlong , Zhang Xu , Liu Kai , Kang Zhongjing 
Published: November 2022

Background:
The use of lung ultrasound for the diagnosis of pulmonary atelectasis remains controversial. Therefore, we performed a protocol for systematic review and meta-analysis to evaluate the diagnostic accuracy of lung ultrasound for the diagnosis of pulmonary atelectasis both in adults and pediatrics.

Methods:
A comprehensive search of several databases from 1966 to October 2022 will be conducted. The databases include Ovid Medline In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, Ovid PsycINFO, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, and PubMed. After screening and diluting out the articles that met inclusion criteria to be used for statistical analysis, the pooled evaluation indexes including sensitivity and specificity as well as hierarchical summary receiver operating characteristic curves with 95% confidence interval were calculated. All statistical analyses were calculated with STATA, version 12.0 (StataCorp, College Station, TX).

Result:
We will synthesize the current studies to evaluate the diagnostic accuracy of lung ultrasound for the diagnosis of pulmonary atelectasis.

Conclusion:
The result of this review will provide more reliable references to help clinicians make decisions for the diagnosis of pulmonary atelectasis.
Efficacy and safety of Yaobitong capsule for acute lumbar disc herniation: A protocol for a multi-center randomized controlled trial
Authors: Zhang Xianshuai , Yang Kexin , Wang Siyi , Tang Bin , Yin He , Lei Qunhui , Zhou Guohui , Gu Mingyu , Shi Mingpeng , Zhao Changwei , Li Shaojun , Li Zhenhua 
Published: November 2022

Background:
There are few effective conservative therapies for acute lumbar disc herniation (LDH), and the choice of nonsteroidal anti-inflammatory drugs is not recommended for all patients. The purpose of this study was to compare the effect of Yaobitong capsule with celecoxib capsule, and to further confirm the safety and efficacy of Yaobitong capsule.

Methods:
This study is a large sample multicenter randomized controlled trial. Eight hospitals served as sub centers to recruit patients. A total of 258 patients are divided into Yaobitong group and celecoxib group according to the ratio of 1:1. Celecoxib or Yaobitong capsule was taken orally for 14 days. Patients will complete the trial after 3 months of follow-up, and independent statisticians who are blinded to random assignment will analyze the data using SAS 9.3 software. The primary outcome was the visual analogue scale (VAS) score after 14 days of treatment, and Japanese Orthopaedic Association (JOA), Oswestry Disability Index (ODI), and SF-12 will be regarded as secondary outcomes. Safety indexes will be recorded before and after treatment, and adverse events (AEs) will be recorded throughout this trial.

Discussion:
This study will evaluate the efficacy and safety of Yaobitong capsule in treating LDH. The experimental results will provide evidence support to treat LDH with Yaobitong capsule.