bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Comparison Between Clevidipine and Nicardipine in Cerebrovascular Diseases: A Systematic Review and Meta-analysis
Authors: Seifi Ali , Jafari Amirhossein Azari , Mirmoeeni Seyyedmohammadsadeq , Shah Muffaqam , Jafari Mohammadjavad Azari , Nazari Shahrzad , Godoy Daniel Agustin 
Published: October 2022

Abstract
Background: The term "cerebrovascular diseases (CVDs)" refers to a broad category of diseases that affect the brain's blood vessels and cerebral circulation. According to a substantial body of evidence, controlling acute hypertension (HTN) by antihypertensive drugs such as clevidipine and nicardipine can be a highly efficient method of lowering the incidence of CVDs. The aim of this systematic review and meta-analysis is to compare and analyze the outcomes of clevidipine and nicardipine in CVD patients for the first time.
Methods: For identifying potential eligible studies, two independent researchers systematically searched PubMed, Scopus, and Web of Science online databases, and the gray literature search, including Google scholar and hand-searching, were performed. Included studies were any observational (Retrospective/prospective cohort and cross-sectional) literature that compares adult patients receiving clevidipine or nicardipine for controlling HTN in the setting of CVD.
Results: We reviewed 487 articles and finally included 5 studies, including 546 patients (211 received clevidipine, and 335 received nicardipine). The pooled standardized mean difference (SMD) for time to goal SBP was -0.04 (95% CI: [-0.66; 0.58], p-value: 0.86, I2: 79.0%, pooled MD: -12.90 min), meaning that the clevidipine group has shorter time to goal systolic blood pressure (SBP) compared to nicardipine. The pooled SMD for total volume infusion was -0.52 (95% CI: [-0.93; -0.12], p-value: 0.03, I2: 0.0%, pooled MD: -1118.81 mL), showing a notable less total volume infused to patients in the clevidipine group.
Conclusion: We found that clevidipine reaches the SBP goal faster than nicardipine; however, there is no statistically significant difference between the two drugs. The total volume infused to achieve the goal SBP is significantly less in the clevidipine group. Both clevidipine and nicardipine are safe, and their adverse effects are comparable. Further prospective studies in a blinded and protocolized condition are needed to compare clevidipine and nicardipine in CVD patients on a large scale.
“I want to do more in life than just…be a disability person”: Young people with intellectual disability speak out about life after school
Authors: Mogensen Lise , Drake Gabrielle , McDonald Jenny , Sharp Nicole 
Published: October 2022

Abstract

Background
The transition from school to adult life is challenging for young people with intellectual disability. The study aim was to explore young people’s experiences of transition and post-school options and whether experiences were influenced by the ‘choice and control’ impetus in current disability policy in Australia.
Methods
A co-designed, qualitative study. Thematic data analysis of surveys, semi-structured interviews, and focus groups with 27 young people with intellectual disability.
Results
Participants found transition planning at school inconsistent or lacking and felt excluded from decision-making about their lives. Accessing meaningful services, training, and employment beyond volunteering was challenging and enduring, leaving participants in perpetual state of transition, feeling lost, and missing out of adult milestones.
Conclusions
Policy, system, and service gaps must be addressed with a nationally consistent and accountable approach that truly supports choice and control for young people with intellectual disability in transitioning from school into meaningful adult lives.
Independent double-center observational study of minimally invasive sacroiliac joint fusion for sacroiliac joint dysfunction: one-year results
Authors: Hermans Sem M. M. , Knoef Rob J.H. , Schuermans Valérie N.E. , Schotanus Martijn G.M. , Nellensteijn Jorm M. , Santbrink Henk , Curfs Inez , Hemert Wouter L.W. 
Published: October 2022

Abstract

Background
A substantial part of patients with chronic low back pain, the origin is located in the sacroiliac joint (SIJ). Minimally invasive sacroiliac joint fusion (MISJF) is increasingly being implemented as a treatment option in SIJ dysfunction. Despite remaining controversy, evidence continues to increase. This study evaluates the clinical results and safety of MISJF in a double-center consecutive case series in patients with SIJ dysfunction over a one-year observation period.
Methods
SIJ complaints were diagnosed after history taking, physical examination and least a 50% reduction of SIJ pain 30 to 60 minutes following image-guided injection. Primary outcome measures were patient reported outcome measurements (PROMs), consisting of Visual Analogue Scale (VAS) pain score and EuroQol 5-dimensions 3-levels (EQ-5D-3L). Patients’ perspectives on the effects of surgery were collected through questionnaires. Secondary outcome measures were implant positioning and (serious) adverse events ((S)AE’s).
Results
A total of 29 patients were included. In 44.8% of patients SIJ dysfunction was of postpartum origin. The mean VAS-pain score improved from 7.83 (± 1.71) to 4.97 (± 2.63) postoperatively (p < 0.001). EQ-5D-3L score improved from 0.266 (± 0.129) to 0.499 (± 0.260) postoperatively (p < 0.001). Opioid consumption decreased from 44.8–24.1% postoperatively (p = 0.026). In 13.7% of patients an (S)AE occurred.
Conclusion
MISJF appears to be an effective and safe procedure in this cohort. Statistically significant and clinically relevant improvements in pain and QoL were observed one-year postoperatively. Future studies should focus on the long-term outcomes to further evaluate the safety and effectiveness of MISJF.
Switching Anti-Windup Design for Discrete-Time Switched Systems Under Input Saturation
Authors: HOUTI Smail , Berdjag Denis , Defoort Michael , Lauber Jimmy 
Published: October 2022

Abstract
In this paper, the tracking problem for discrete-time switched systems subject to actuator saturation and exogenous input is considered. The considered class of systems encompasses discrete-time systems subject to asymmetric saturation or time-varying saturation. Using switched Lyapunov functions and L2-gain analysis, a one-step method is proposed to design the controller and the anti-windup compensator. Some sufficient conditions are derived to guarantee local asymptotic stability and L2-performance of the closed-loop system in terms of linear matrix inequalities (LMI). To illustrate the advantages of the proposed scheme, comparisons with existing schemes are provided. At last, the effectiveness of the proposed scheme is illustrated on the velocity tracking problem of a heavy train with asymmetric saturation constraints.
Longitudinal study of sexual dysfunction and its influencing factors in breast cancer patients: a trajectory analysis model
Authors: Wang Yingyin , Zhang XiaoLu , Chen ShouLi , Wang GuoRong , Zhang Tian , Liu Yao , Li Qiao qiao 
Published: October 2022

Abstract
Objective: This study aims to explore the trajectory of sexual dysfunction (FSD) in breast cancer patients up to 9 months after diagnosis and to analyze factors influencing the trajectory.
Methods: A longitudinal study was used to investigate 225 patients with a first diagnosis of breast cancer in a tertiary care hospital in Sichuan. Patients were dynamically assessed with the Female Sexual Function Index (FSFI) at baseline, 1 month after diagnosis (T1), 3 months after diagnosis (T2), 6 months after diagnosis (T3), and 9 months after diagnosis (T4).
Results: The incidence of FSD in breast cancer patients at each follow-up time point in this study was 30.7%（T0), 80.4%(T1), 81.8%(T2), 87.5%(T3), and 78%(T4), with the greatest severity of FSD at T3. The trajectory of FSD development in the 3 groups of trajectories was the optimal model, accounting for the "FSD improvement group" (22.9%), "FSD severe group" (56.1%), and "FSD worsening group" (21%). Age less than 40 years (β=2.811, P=0.048), occupation as cadre and professional (β=1.740, P=0.033), pre-treatment poorer sexual arousal (β=-2.625, P=0. 011), poorer sexual satisfaction (β=-1.555, P=0.033), and higher sexual pain (β=-1.465, P=0.032) were influencing factors for the "FSD severe group". Chemotherapy cycles ≥8 cycles (β=-1.274, P=0.040), cadre and professional occupation (β=2.172, P=0.009) were the influencing factors in the "FSD worsening group".
Conclusion: Early detection of those at risk for FSD is advised for effective intervention due to the high incidence of FSD in breast cancer patients during treatment and the inability of sexual function to return to pretreatment levels at month nine of treatment. Trajectory analysis revealed that the trajectory of FSD development in breast cancer patients showed a large heterogeneity, suggesting that clinical interventions should be tailored to the individual. Priority treatment targets for intervention included patients who were under 40, ≥8 cycles of chemotherapy, professionals, low levels of pre-treatment sexual arousal and sexual satisfaction, and high levels of pre-treatment sexual pain.
Reservoir Computing with Emergent Dynamics in a Magnetic Metamaterial
Authors: Vidamour Ian , Swindells Charles , Venkat Guru , Manneschi Luca , Fry Paul , Welbourne Alexander , Rowan-Robinson Richard , Backes Dirk , Maccherozzi Francesco , Dhesi Sarnjeet , Vasilaki Eleni , Allwood Dan , Hayward Thomas 
Published: October 2022

Abstract
In Materio reservoir computing (RC) leverages the response of physical systems to perform computation. Dynamic systems with emergent behaviours (where local interactions lead to complex global behaviours) are especially promising for RC, as computational capability is determined by the complexity of the transformation provided. However, it is often difficult to extract these complex behaviours via device tractable measurements that can be interfaced with standard electronics. In this paper, we measure the emergent response of interconnected magnetic nanoring arrays using simple electric transport measurements, observing distinct computationally promising dynamic behaviours in device response. Then, we employ three distinct reservoir architectures that exploit each of the behaviours to perform benchmark tasks with contrasting computational requirements on a single device with state-of-the-art accuracies for spintronic computing platforms.
A Prototype-Based Neural Network for Image Anomaly Detection and Localization
Authors: Huang Chao , Kang Zhao , Wu Hong 
Published: October 2022

Abstract

Image anomaly detection and localization perform not only imagelevel anomaly classification but also locate pixel-level anomaly regions. Recently, it has received much research attention due to its wide application in various fields. This paper proposes ProtoAD, a prototypebased neural network for image anomaly detection and localization. First, the patch features of normal images are extracted by a deep network pre-trained on nature images. Then, the prototypes of the normal patch features are learned by non-parametric clustering. Finally, we construct an image anomaly localization network (ProtoAD) by appending the feature extraction network with the L2 feature normalization, a 1 × 1 convolutional layer, a channel max-pooling, and a subtraction operation. We use the prototypes as the kernels of the 1 × 1 convolutional layer; therefore, our neural network does not need a training phase and can conduct anomaly detection and localization in an end-to-end manner. Extensive experiments on the MVTec AD dataset demonstrate that ProtoAD achieves competitive performance compared to the state-of-the-art methods with a higher inference speed. The source code will be released on GitHub.
Prognostic value of WT-1 gene combined with recurrent cytogenetic gene in acute myeloid leukemia
Authors: Zhang Qing , Liu Linlin , Yan Haotian , Ren Xiyang , Zhou Mei , Xiong Shudao , Wang Huiping , Tao Qianshan , Zhai Zhimin 
Published: October 2022

Abstract
Background: Wilms tumor gene 1 (WT-1 gene) is overexpressed in most patients with acute myeloid leukemia (AML) and provides the evidence for an indicator of minimal residual disease (MRD) monitoring, but further studies of the combined prognostic value of WT-1 gene are needed to be illustrated due to its relatively low specificity. The aim of the study is to explore the prognostic value of WT-1 gene combined with recurrent cytogenetic gene in AML.
Methods: We dynamically examined the transcript expression of WT-1 gene in the bone marrow samples of adult patients with AML, and then validated the prognostic value of WT-1 gene with or without recurrent cytogenetic gene.
Results: In AML, the transcript expression of WT-1 gene was closely related to leukemic tumor burden and could act as an accurate indicator of molecular MRD detection. Most patients with low level expression of WT-1 gene after induction and consolidation therapy were significantly associated with favorable relapse free survival (RFS) and overall survival (OS), but there were still 16.7% patients were relapsed and died of primary disease. However, when analyzing of WT-1 gene combined with recurrent cytogenetic gene, none of the patients with low level expression of WT-1 gene and negative of recurrent cytogenetic gene were relapsed and died in the median follow-up time of 19 months (range: 3-94months).
Conclusion: WT-1 gene combined with recurrent cytogenetic gene is a more accurate indicator of MRD monitoring and prognosis evaluation in AML.
Carbon and aeration modulate the flux of reductive pathways in nitrite metabolism by shaping the structure of the functional microbiota in agricultural upland soil
Authors: Wu Xiaogang , Yu Siyu , Sui Weikang , Zhang Xinyu , Li Ji , Wu Qiaoyu , Zhang Xiaojun 
Published: October 2022

Abstract
Background
Denitrification (DNF) and dissimilatory nitrate reduction to ammonium (DNRA) share the common intermediate nitrite during nitrogen anaerobic reduction metabolism. Compared with DNF, which incurs nitrogen loss through gas emission and leaching, DNRA is more economical and environmentally friendly due to the conservation of nitrogen in the form of ammonium. However, the competition mechanism between DNF and DNRA is currently unclear.
Results
Incubations with agricultural soil from the North China Plain (NCP) were conducted under different aeration conditions with the addition of nitrite and different doses of glucose. By measuring the activity of DNF and DNRA, we found that DNF exclusively dominated nitrate reduction when NCP soil was directly anaerobically incubated regardless of the carbon content. However, a significant increase in DNRA activity and attenuation of that of DNF was detected by 15N stable isotopic measurement when the soil samples were incubated aerobically with the addition of glucose prior to anaerobic incubation; specifically, as much as 24 ~ 56% DNF activity was attenuated, and most of that part of nitrite was reduced by DNRA activity under high carbon conditions. Quantitative assays of the nrfA gene and metagenomics data showed a significant increase in DNRA reaction-encoding genes after aerobic incubation. Furthermore, the nrfA sequence analysis showed a significant shift in the composition of DNRA members during aerobic preincubation with an increased relative abundance of specific phylotypes. Hence, environmental changes, especially oxygen and carbon availability, resulted in changes in nitrogen reduction metabolism.
Conclusions
Results from this study indicated that DNRA could be promoted by regulating abiotic factors, such as aeration and the carbon content, to modulate the competition of two metabolic pathways of nitrate/nitrite reduction in agricultural soil, which could be achieved by shifting the abundance of functional facultative anaerobes.
A Numerical Analysis on MHD Hybrid Nanofluid flow and Heat transfer over a Permeable Stretching Sheet under the Influence of Thermal Radiation
Authors: Rao Shiva , Deka P. N. 
Published: October 2022

Abstract
The current investigation considers the two-dimensional time independent MHD flow and heat transfer of a water-based hybrid nanofluid induced by a stretching sheet of porous medium with first order boundary slip conditions. The Effects of thermal radiation, viscous dissipation, and Joule heating are taken into consideration. For investigation hybrid nanoparticles of silver (𝐴𝑔) and alumina (𝐴𝑙2𝑂3) are considered along with water (𝐻2𝑂) as base fluid. Following a suitable similarity transformation, the governing equations are reconstructed as a set of non-linear ordinary differential equations. We have employed the Keller-box numerical technique to solve the equations. The influence of different parameters on the velocity profile and temperature profile are illustrated graphically, whereas its impact on skin-friction coefficient and local Nusselt number are tabulated. From this study, we have concluded that the increase in radiation and magnetic parameter increases the thermal boundary layer thickness. Further it is observed that the speed of the hybrid nanofluid can be controlled by applying magnetic field, porous media and enhancing the volume fraction of the nanoparticles. It is found that the use of hybrid nanofluid (𝐴𝑔−𝐴𝑙2𝑂3/𝑤𝑎𝑡𝑒𝑟) shows better results than the nanofluids with single nanoparticles (𝐴𝑔/𝑤𝑎𝑡𝑒𝑟). The current article shows an excellent comparison with previously published works.
Corneal endothelial cell loss after EX-PRESS surgery depends on site of insertion, cornea or trabecular meshwork
Authors: Otsuka Mitusya , Tojo Naoki , Hayashi Atsushi 
Published: October 2022

Abstract
Purpose
Previously, we reported that the Ex-press® shunt (EXP) was associated with more rapid reduction of corneal endothelial cells when inserted into the cornea rather than the trabecular meshwork (TM). We compared the reduction rate of corneal endothelial cells between the corneal insertion group and TM insertion group.
Methods
This was a retrospective study. We included patients who had undergone EXP surgery and were followed for > 5 years. We analyzed the corneal endothelial cell density (ECD) before and after EXP implantation.
Results
We included 25 patients in the corneal insertion group and 53 patients in the TM insertion group. One patient in the corneal insertion group developed bullous keratopathy. The ECD decreased significantly more rapidly in the corneal insertion group (p < 0.0001), in whom the mean ECD decreased from 2227 ± 443 to 1415 ± 573 cells/mm2 at 5 years with a mean 5-year survival rate of 64.9 ± 21.9%. By contrast, in the TM insertion group, the mean ECD decreased from 2356 ± 364 to 2124 ± 579 cells/mm2 at 5 years, and the mean 5-year survival rate was 89.3 ± 18.0%. The decrease rate of ECD was calculated as 8.3%/year in the corneal insertion group and 2.2%/year in the TM insertion group.
Conclusions
Insertion into cornea is a risk factor for rapid ECD loss. The EXP should be inserted into the TM to preserve the corneal endothelial cells.
Sunspot Extraction and Hemispheric Statistics of YNAO Sunspot Drawings Using Deep Learning
Authors: Yang Zhaoshuai , Yang Yunfei , Feng Song , Dai Wei , Liang Bo , Xiong Jianping 
Published: October 2022

Abstract
The sunspot drawings around the globe provide long historical records for understanding the long-term trends in solar activity cycle. Yunnan Astronomical Observatory (YNAO) in China contributes the relatively continuous sunspot drawings from 1957 to 2015. This paper proposes a new deep learning method named as SPR-Mask to extract pores, spots, umbrae and penumbrae in the YNAO sunspot drawings. SPRMask consists of three parts: backbone, shared head and mask branch. Especially, it adopts a scale-aware attention network (SAAN) and a PointRend module in the mask branch to improve the accuracy of target edge segmentation. Besides that, each sunspot belonging to northern or southern (N-S) hemisphere is determined by transforming its cartesian coordinates to spherical coordinates after extracting P, B0 and L0 handwritten in sunspot drawings using a revised Lenet-5 deep learning method. The precision, recall and AP of SPR-Mask are 0.92, 0.93, and 0.92, respectively. The test results show the SPR-Mask method has a good performance. The numbers and areas of pores, spots, umbrae and penumbrae for N-S hemisphere are presented and analyzed separately. The YNAO data are also compared with Royal Greenwich Observatory (RGO), Kanzelh¨ohe Observatory (KSO) and Purple Mountain Astronomical Observatory (PMO) data. The results show they have similar trends, high correlations and similar N-S asymmetries. All data of YNAO are public shared at https://github.com/yzs64/YNAO sd/, which are abundant complementary to the other sunspot catalogues in the world.
The Impact of Agricultural Credit on the Cattle Inventory and Deforestation in Colombia: A Spatial Analysis
Authors: Mejía Daniela , Díaz Manuel , Enciso Karen , Bravo Aura , Florez Fernando , Burkart Stefan 
Published: October 2022

Abstract

The relationship between agricultural credit and agricultural production as well as the impacts on sustainable development (i.e., poverty alleviation, reduction of inequalities, food and nutrition security, and stimulation of economic growth) have been widely documented. The objective of this study is to analyze the impact of credit on cattle production and deforestation in Colombia through spatial panel data models. For this purpose, a departmental data panel for the period 2011 to 2020 was built, based on available information from public entities. The results suggest that in Colombia, the relationship between access to credit and cattle production is significant and can be either negative or positive. In addition, there is evidence of spatial dependence, meaning that cattle production in one department is being affected by cattle production in a neighboring department or by all the departments that make up the national territory. Regarding deforestation, results show that, although the number of cattle present in a department does affect its annual deforestation rate due to a poor coverage of sustainably intensified cattle ranching systems, there is no relationship between deforestation and the access to credit nor any spatial correlations.
Hepatic reticular hemangioendothelioma in an infant: a rare case and literature review
Authors: Yu Xiao-hui , Jia Gang-gang , Li Bin , Qin Jian-wei , Li Yue-sheng 
Published: October 2022

Abstract
Reticular hemangioendothelioma is a rare vascular malignant tumor that mostly occurs in women. Usually located in the trunk and limbs, rarely involving the mouth, perineum, pleura, kidneys, and so on. Because of its atypical pathological manifestations, it should be differentiated from intravascular papillary hemangioendothelioma, angiosarcoma, spindle cell hemangioma, etc. Here, we report a case of liver RH in a 7-month-old infant and review related literature to improve understanding of the disease.