bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining the Incidence and Management of Postoperative Scrotal Hematoma after Primary and Complex Three-piece Inflatable Penile Prosthesis Surgery
Authors: Simhan Jay , Braun Avery , Swerdloff Daniel , Sudhakar Architha , Patel Rutul , Gross Martin 
Published: December 2022

Abstract
Background:
Scrotal hematoma is a challenging complication of penile prosthesis surgery. We characterize the risk of hematoma formation with implementation of standardized techniques to mitigate hematomas and assess for any associated factors in a large multi-institutional penile implant cohort.
Materials and Methods:
A retrospective review from February 2018 to December 2020 of all patients who underwent inflatable penile prosthesis (IPP)implantation at 2 high volume implant centers was conducted. Cases were defined as ‘complex’ if they involved revision, salvage with removal/replacement, or were performed with concurrent penile, scrotal or intra-abdominal surgeries. The incidence of scrotal hematoma among primary and complex IPP recipients was measured and modifiable and innate risk factors associated with hematoma formation within the two cohorts were tracked.
Results:
Of 246 men who underwent IPP, 194 (78.9%) patients underwent primary implantation and 52 (21.1%) were complex. Although patients in the complex group had comparable drain outputs to non-hematoma patients on POD0 (66.8cc vs 49.6, p=0.488) and POD1 (20.0cc vs 40.3, p=0.114), hematomas in the complex group had a higher propensity for OR evacuation (p=0.03). Difference in duration of temporary device inflation between 2 and 4 weeks did not contribute to hematoma formation. Postoperative hematoma formation in complex cases (5/52, 9.6%) trended towards a higher incidence than primary cases (7/194, 3.1%) (HR=2.61, p=0.072).
Conclusions:
Complex IPP surgery performed for revision or with ancillary procedures are more likely to result in clinically significant hematomas that require surgical management, suggesting a need for heightened caution in managing these individuals.
Intrauterine treatment and outcome of fetal persistent atrial flutter: a case report
Authors: Runxuan Du , Fangna Wang , Yuewen Dong , Wei Chu , Lishuang Ma , Jian Gao 
Published: December 2022

Abstract
Background: Fetal atrial flutter (AF) accounts for 30% of all fetal tachyarrhythmias, and more than 80% of fetal atrial flutter is 2:1 atrioventricular conduction. When a severe persistent arrhythmia occurs, intrauterine therapy is the first choice, and childbirth is not the first choice.
﻿Case presentation: A 32-year-old Chinese multipara at 30+2 weeks of gestation whose ultrasonographic examination revealed fetal persistent atrial flutter (atrial rate 219-445 beats/min, ventricular rate 219-228 beats/min, 2:1 or 1:1 down transmission) and a small amount of ascites. The fetal heart rhythm did not recover even after oral administration of digoxin and sotalol to the gravida. At 32+3 weeks of gestation, the fetal intramuscular injection of celanide was administered under the guidance of ultrasound. The fetal ventricular rate decreased 6 days after operation and the ascites disappeared. At 33+3 weeks, due to the poor tolerance of the gravida to the drugs, ﻿the infant was delivered by cesarean section. 5 minutes after birth, ﻿the infant heart rhythm was spontaneously converted to sinus rhythm. Follow-up to 1 year after birth, the infant hasn't had atrial flutter.
﻿Conclusions: In this case, the fetal heart rhythm automatically reverted to sinus rhythm after birth which appears that when the transplacental drug treatment failed, intrauterine treatment of the drug should be considered. And the prognosis of fetal atrial flutter is optimistic.
Ampere-hour-scale soft-package potassium-ion hybrid capacitors enabling 6-minute fast-charging
Authors: Li Huanxin , Gong Yi , Yang Kai , Zhou Haihui , Li Jing , Mao Boyang , Zhang Jincan , Shi Yan , Deng Jinhai , Mao Mingxuan , Huang Zhongyuan , Jiao Shuqiang , Kuang Yafei , Zhao Yunlong , Luo Shenglian 
Published: December 2022

Abstract
Extreme fast charging of Ampere-hour (Ah)-scale energy storage devices targeting charging times of less than 10 minutes can dramatically accelerate mass-market adoption of electric vehicles, advance the Net-Zero, and secure the grid. However, restricted by the inherent reaction mechanism and safety hazards of conventional batteries, this technical barrier is still difficult to break through in Ah-scale devices. In this work, we report novel 1Ah soft-package potassium-ion hybrid capacitors (PIHCs), which combine the merits of high-energy density of battery-type anode and high-power density of capacitor-type cathode, featuring an ultra-high voltage up to 4.8 V, high full-cell level energy density of 140 Wh kg−1 (based on the whole mass of device) with a full charge of 6 mins. Additionally, the full cells (1 Ah) exhibit excellent cycling stability (88% capacity retention after 200 cycles under 10 C) and exceptional voltage retention. This outstanding performance benefits from a holistic optimization of electrode materials, electrolyte and cell configuration, especially the construction and integration of defect-rich, high specific surface area N-doped carbon nanotubes (N-CNTs) cathode, MnO quantum dots inlaid spacing-expanded CNTs anode, as well as the binder- and current collector-free cell design, which provides clear guidance for practical applications of PIHCs.
Potential of secretome of human fetal cartilage progenitor cells as disease modifying agent for osteoarthritis
Authors: Tran Ngoc-Trinh , Park In-Su , Truong Minh-Dung , Yun Hee-Woong , Min Byoung-Hyun 
Published: December 2022

Abstract
Osteoarthritis (OA) is caused by an imbalance in the synthesis and degradation of cartilage tissue by chondrocytes. Therefore, a therapeutic agent for OA patients that can positively affect both synthesis and degradation is needed. However, current nonsurgical treatments for OA can barely achieve satisfactory long-term outcomes in cartilage repair. Human fetal cartilage progenitor cells-secretome (ShFCPC) has shown potent anti-inflammatory and tissue-repair effects; however, its underlying mechanisms and effects on OA have rarely been systematically elucidated. This study aims to analyze and evaluate the potency of ShFCPC in modifying OA process. Herein, secreted proteins enriched in ShFCPC have been characterized, and their biological functions both in vitro and in vivo in an OA model are compared with those of human bone marrow-derived mesenchymal stem cells-secretome (ShBMSC) and hyaluronan (HA). Secretome analysis has shown that ShFCPC is significantly enriched with extracellular matrix molecules involved in many effects of cellular processes required for homeostasis during OA progression. Biological validation in vitro has shown that ShFCPC protects chondrocyte apoptosis by suppressing the expression of inflammatory mediators and matrix-degrading proteases and promotes the secretion of pro-chondrogenic cytokines in lipopolysaccharide-induced coculture of human chondrocytes and SW982 synovial cells compared with ShBMSC. Moreover, in a rat OA model, ShFCPC protects articular cartilage by reducing inflammatory cell infiltration and promoting M2 macrophage polarization in the synovium, which directly contributes to an increase in immunomodulatory atmosphere and enhances cartilage repair compared to ShBMSC and HA. This shows great potential for ShFCPC as a novel agent for modifying OA process.
Universal growth of graphene on arbitrary insulating substrates
Authors: Li Junzhu , Yuan Yue , Lanza Mario , Abate Iwnetim , Tian Bo , Zhang Xixiang 
Published: December 2022

Abstract
Graphene synthesis on insulating substrates is a cornerstone for research on low-dimensional materials. However, it is challenging to grow graphene on insulators due to the lack of metal catalysts, lattice mismatch, and other factors. Although considerable approaches have been explored, it is still vital to develop a synthetic approach with general applicability. Herein, a universal growth strategy is proposed to synthesize graphene on arbitrary insulating substrates with relatively high efficiency. A non-adhered metal foil–insulator substrate has been designed, and a high-temperature near-melting annealing treatment has been used for obtaining high-quality graphene on insulators. Characterization results indicate that as-grown graphene exhibits uniform monolayer, defect-free structure, and smooth surface. Utilizing the same approach, graphene bilayers and trilayers have been fabricated on sapphire, and high-quality graphene has also been universally achieved on other insulating substrates. The proposed strategy could guide the production of large-area graphene-based van der Waals heterostructures on arbitrary substrates.
Effects of Humor Comprehension on Dynamic Cognitive Processes of Insight: An Event-Related Potential Study
Authors: Sun Cuicui , Liu Guanxiong , Wu Jieqing , Xu Liping , Zhou Xinqi , Zhao Qingbai , Zhou Zhijin 
Published: December 2022

Abstract
Some questionnaires and behavioral studies have examined the effect of humor on insight. However, the time course of the effects of humor on the stage of insight remains unclear. This study explored the effect of humor comprehension on insight with event-related potential (ERP) technology using verbal humorous jokes and two-part allegorical sayings. The results show that the average amplitude of the novel semantic association (creative solution) in N400 (350−450 ms) is significantly larger than that of the ordinary semantic association (ordinary solution) in the two priming groups (humor priming and non-humor priming). The amplitude in the LPC (600−900 ms) of novel semantic associations in the humor priming group was significantly smaller than that of the non-humor priming group. The results suggest that the effect of humor comprehension on insight is not reflected in the early breaking of the mindset process of insight but the formation of the novel association process.
PRDM16 deficiency triggered by TGF-β signaling aggravated renal fibrosis by promoting tubular mitochondrial dysfunction
Authors: yuan qian , tang ben , Wan Chao , Xie Ya-Ru , Xie Yajuan , zhu yuting , Su Hua , Zhang Chun 
Published: December 2022

AbstractTGF-β signaling is the master modulator of renal fibrosis. However, its targeting drugs are failed to prevent the progression of chronic kidney disease (CKD) in clinical trials due to the extensive biological regulation of TGF-β signaling. It is necessary to investigate the precise downstream of TGF-β signaling that regulates renal fibrosis. In this study, we found that transcription factor PRDM16 expressed by human renal tubular epithelial cells was reduced markedly by TGF-β. Mechanistically, the activated Smad3 induced by TGF-β interacted with the cofactor, H-Ras, and bound to the promoter of PRDM16 to downregulate its transcription. Tubular-specific knockout of PRDM16 promoted renal fibrosis of unilateral ureteral occlusion (UUO) and unilateral ischemia-reperfusion injury (UIRI) mice by aggravating mitochondrial dysfunction.In vitro, PRDM16 blocked TGF-β-induced mitochondrial injury, and lipid deposition by upregulating PGC-1α. PRDM16 supplementary therapy preserved renal function and ameliorated the progression of renal fibrosis by protecting mitochondrial function. We report a novel downstream of TGF-β signaling, PRDM16 for attenuating renal fibrosis by protecting tubular mitochondrial function.
Lymphoma OR Brucellosis: a Case Series Study
Authors: Rostami Parsa , Shabani Shiva , Fattahi Fahimeh 
Published: December 2022

Abstract
Background: As a zoonotic disease, human brucellosis has a wide variety of clinical manifestations, ranging from multisystem involvement to asymptomatic infection.
Case Presentation: Cases with hematological abnormalities and lymphadenopathies at a referral unit to a cancer hospital from September 2021 to August 2022 were described. Follow-up and clinical symptoms led to brucellosis being diagnosed.
Conclusion: Exist of lymphadenopathies associated with hematological abnormalities led to challenges in our diagnosis, especially the observation of mesenteric and retroperitoneal lymphadenopathies. A proper diagnosis and treatment for brucellosis lead to the complete resolution of lymphadenopathies. As far as we know from the literature, the association of rare symptoms with typical symptoms of brucellosis may be very confusing and delay the diagnosis. Therefore, these case reports can highlight symptoms of brucellosis that mimic a primary hematologic disorder for better and faster diagnosis.
Impact of primary glaucoma on Health-Related Quality of Life in China： The Handan Eye Study
Authors: Song Di , Fan Sujie , Zhou Qiang , Yang Xiaohui , Li Sizhen , Lohfeld Lynne , Zhou Weihe , Congdon Nathan , Liang Yuanbo , Wang Ningli 
Published: December 2022

Abstract
Objectives: To assess health-related quality of life (HRQOL) by EQ-5D among glaucoma patients in the Handan Eye Study (HES), as well as the factors that influence the quality of life.
Methods: A central clinic in the county hospital, a temporary clinic in the targeted villages, or at the participant’s home. The Handan Eye Study (HES) is a population-based prevalence study of eye disease in rural Yongnian County, northern China. A total of 99 adults with glaucoma were enrolled for analysis, including 67 with primary open-angle glaucoma (POAG) and 32 with primary angle-closure glaucoma (PACG). And 256 selected people with better visual acuity and visual field but Without Primary Glaucoma. Results of ophthalmic examinations and socio-economic information were recorded. HRQOL was measured using the EQ-5D, and visual function (VF) and vision-related quality of life (VRQOL) were evaluated using a Visual function-quality of life (VF-QOL) instrument.
Primary and secondary outcome measures: EQ-5D and VF-QOL score.
Results： The mean ± standard deviation (SD) scores on the EQ-5D, VF, and VRQOL for the 99 glaucoma cases were 0.98±0.04, 87.9±15.2, and 95.5±12.8 respectively. Utility values were significantly lower among participants with glaucoma (0.98±0.04) compared to those without (0.99±0.02, P = 0.008), even after adjusting for age, gender, education level, family income, and comorbidity (P = 0.02). There was a significantly lower utility value (0.92±0.08) among patients with lower VRQOL total score (55.4 ± 11.5) compared to higher (0.99 ± 0.03, P = 0.036), even after adjustment for age and family income (P = 0.006).
Conclusion: Patients with glaucoma, particularly those with poor VRQOL, exhibited lower HR-QOL than those without. Early diagnosis and prevention facilitated by government health insurance may enhance VF-QOL for glaucoma patients, especially for PACG.
Can We Predict Gastric Leaks after Laparoscopic Sleeve Gastrectomy by Evaluating the Complete Blood Count on Postoperative Day One?
Authors: Seyit Hakan , Alis Halil 
Published: December 2022

Abstract

Background: We assessed whether postoperative day-1(POD-1) complete blood count(CBC) test parameters, including red cell distribution width(RDW), mean platelet volume(MPV), plateletcrit(PCT), platelet-to-lymphocyte ratio(PLR), and neutrophil-to-lymphocyte ratio(NLR), could identify patients with gastric leaks after laparoscopic sleeve gastrectomy(LSG).
Methods: Patients with postoperative gastric leaks(n=36) and patients with no complications that were selected by age-sex-BMI matching(n=254) were included into the study. The levels of RDW, MPW, PCT, PLR, and NLR were compared between groups in univariate analyses. Receiver operating characteristic(ROC) curve analysis was run for CBC parameters with a p-value<0.05 in univariate analyses. The area under the curve(AUC) was evaluated, and a cut-off value was determined. Sensitivity, specificity, likelihood ratio(LR), positive predictive value(PPV), negative predictive value(NPV), and accuracy were calculated.
Results: The level of PCT was significantly lower while levels of PLR and NLR were significantly higher in patients with postoperative gastric leaks as compared to those without(p<0.05). The AUC of both PCT and PLR was less than 0.750, while the AUC of NLR was 0.911. NLR cut-off at 3.6 yielded 80% sensitivity, 92% specificity, and LR of 10. In the study cohort, PPV of 59%, NPV of 97%, and an accuracy of 90% were found.
Conclusions: Our results suggest that NLR at POD-1, with a cut-off value of 3.6, is a useful indicator of postoperative gastric leak who underwent LSG. We recommend the use of this easily calculated parameter in clinical practice.
Elastofibroma Dorsi: Demographic, Clinical and Radiological Assessment
Authors: Samimi Kaveh , Hakim Peyman Kamali , Zeinalkhani Hadise , Ahmadinejad Nasrin , Zeinalkhani Fahimeh , Delazar Sina 
Published: December 2022

Abstract
Background: Elastofibromadorsi is an uncommon benign pseudotumor. We aimed to assess its demographic, clinical and radiological features.
Materials and methods: We retrospectively re-evaluated all thoracic CT scans and MRI's of Babak imaging center to identify cases of elastofibromadorsi. Such variables as age, gender, weight, height, body mass index, handedness, and symptoms were extracted from their medical records. Hounsfield numbers and mass laterality were determined by three radiologists. Also, suspicious patients were asked to undergo punch biopsies. Data were analyzed using SPSS software.
Results: Prevalence rate of elastofibroma dorsi was 1.2%, after reviewing 10,056 imaging records. Most patients (69%) were women (p<0.05). Mean age±SD was 62.7±2.3 (range: 28-72) with the highest frequency in the middle age (p<0.05). Majority of cases were unilateral (77.5%), commonly on the right side (95% of unilateral lesions). Eighty-eight percent of right- vs. 71% of left-handed individuals had the mass ipsilateral to their dominant side (p<0.05). About 2/3 of patients were asymptomatic. Mean±SD Hounsfield unit of the masses was 33±4.1 (range:19-48), while for the adjacent muscle, Hounsfield unit it was 46±3.7 (range:35-55). All taken biopsies confirmed the diagnosis of elastofibromadorsi.
Conclusion:Most cases were found unilaterally on the right side of middle-aged women.
Modeling of solid-liquid coupling and material removal in robotic wet polishing
Authors: Pan Jie , Chen Fan , Meng Jin , Zhao Huan , Dong Zhaocheng , Pu Donglin , Ruan Peng 
Published: December 2022

Abstract
In this paper, the flow characteristics of the polishing fluid between the polishing pad and the workpiece are studied for the robotic wet polishing process, and the distribution of the polishing fluid radial velocity Ur and the liquid film thickness z at different rotating radii r are revealed. The two-dimensional computational domain consisting of the polishing pad surface, the workpiece wall and the polishing fluid is established. The particle-liquid two-phase flow simulation is carried out in Fluent, and the influence of different rotation rate ω of the polishing pad and different robot swing speeds v2 on the change and distribution of polishing fluid flow rate and temperature are elaborated. The position distribution of the abrasive particles in the wet polishing process and the velocity distribution of particles in the x and y directions impacting on the workpiece surface are simulated and analyzed for polishing fluids with different average abrasive diameters dp. The three-dimensional calculation domain for wet polishing is established; the workpiece surface erosion is simulated in Fluent; the material removal rate MRR and standard deviation of material removal σ on the workpiece surface are calculated considering different combinations of polishing fluid properties Ci and polishing kinematics Pi. Under the same process parameters, the material removal rate test value MRRT and the standard deviation of material removal test value σT are compared with the simulated values, respectively. The results show that under the combination of 64 groups of physical parameters C1-C64 of the polishing fluid, the error between the test value MRRT, σT and the simulation value MRR, σ is within 5%. With 64 sets of polishing kinematics parameters P1-P64, the average error between the test value MRRT and the simulated value MRR is 4.19%. However, when the polishing pad rotation rate ω is high, there is an inefficient polishing area in the smaller radius from the polishing pad rotation center, which results in a lower MRRT in some tests than that in simulation, with an maximum error of 8.1%. The average error between the test value σT and the simulation value σ is 3.77%. When the pressure P of the polishing pad is high, the large particles embedded in the polishing pad surface follow its rotation, causing deep scratches on the workpiece surface, which results in a larger σT in some tests, with an maximum error of 7.8%. In conclusion, the material removal principle and the influence of different process parameters in the robotic wet polishing process are revealed in this paper.through modeling and simulation of the particle-liquid two-phase flow, giving an accurate estimation of the material removal rate of the robotic wet polishing process.
Synchrotron Fourier transform infrared microspectroscopy (SFTIRM) analysis of beta amyloid aggregation/clearance in Al-induced Alzheimer’s’ disease in rat brain hippocampal tissue
Authors: Khalil Safaa K. H. , hotaby W. El , Ahmed Gehan , Sherif Hadeer H.A. , Kamel Gihan , Abbas Lamyaa 
Published: December 2022

Abstract
Aluminium (Al) can trigger protein misfolding, beta amyloid (Aβ) aggregation and induced Alzheimer’s disease (AD)-like in rat model. Lepedium sativum (LS) water extract proved promising curative effects and its ability to restore the protein integrity was reported in our previous reports. In this study, we utilized Synchrotron Fourier Transform Infrared Microspectroscopy (SFTIRM) and multivariate analysis to investigate and monitor more thoroughly the process of protein misfolding in response to Al and LS treatment in rat hippocampal brain tissue. The results revealed a marked increase in the protein β-structure in AD group after 42d over the random coil structure. Meanwhile, after 65d ~ 91% of the amide I is random coil and the rest is anti-parallel β-sheets, alpha helix structure is absent in both tested times. Incredibly, this random coil structure is totally absent in the curative group; instead it is dominated by a drastic increase in the protein β-structure suggesting the clearance of Aβ takes place through β-structure transit phase. The role of β –structure & random coil as a transit phase in transformation of Aβ and/or clearance in response to AL and LS treatment is supported by different calculated %area ratios measurements. SFTIRM gave unique and deeper cluster of data.