bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHANGES OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY PARAMETERS AFTER INTERNAL LIMITING MEMBRANE PEELING COMPARED WITH NONPEELING IN EPIRETINAL MEMBRANE SURGERY
Authors: Gabriel Maximilian , Djavid Daniel , Innauer Felix , Ivastinovic Domagoj , Seidel Gerald , Mayer-Xanthaki Christoph , Ansari-Shahrezaei Siamak , Wedrich Andreas , Haas Anton 
Published: July 2022

Purpose:
To prospectively compare microvascular changes of internal limiting membrane (ILM) peeled and nonpeeled eyes in patients with idiopathic epiretinal membranes using optical coherence tomography angiography.

Methods:
Forty-two patients with epiretinal membranes underwent vitrectomy with (n = 22) or without ILM peeling (n = 20). The mean superficial capillary plexus foveal avascular zone area change between preoperative and three-month postoperative readings served as the main outcome measure. Secondary outcome parameters included mean changes in superficial capillary plexus parafoveal vessel density, central foveal thickness, retinal volume, and best-corrected visual acuity.

Results:
Mean superficial capillary plexus foveal avascular zone area change (μm2) was 59 ± 74 in the ILM nonpeeling group compared with −12 ± 86 in the ILM peeling group (P = 0.007). Similarly, mean superficial capillary plexus parafoveal vessel density change (%) was higher in the ILM nonpeeling group (ILM nonpeeling 4 ± 4, ILM peeling −2 ± 6, P = 0.003). The mean retinal volume reduction was higher in the ILM peeling group, and this difference also reached statistical significance (P = 0.036). There were no intergroup differences in mean central foveal thickness change and mean best-corrected visual acuity change (P = 0.409 and P = 0.440, respectively). Epiretinal membrane/ILM separation was achieved in 23 of 51 patients.

Conclusion:
The macular microvasculature demonstrated more remodeling in the ILM nonpeeling group after three months.
Tanner Stages and Pubertal Development
Authors: Hamlin Amy , Robertson Michelle , Wilson Debra Rose 
Published: July 2022

Abstract
Puberty typically follows a predictable pattern that can be assessed using the Tanner stages or Sexual Maturity Rating scale. Clinicians can use this tool to evaluate and monitor progress in female and male puberty. The timing and sequence of puberty are important indicators of the growth and development of pediatric patients. Stages of puberty and normal findings must be known before variations can be identified. Pubertal changes that fall outside the normal timeline or trajectory are considered abnormal and must be investigated. Treatments for abnormal variations are based on pathologic versus idiopathic causes. Nurses, as members of the interprofessional collaborative team, serve an important role by obtaining data, monitoring progress, providing health education, performing ongoing assessment/evaluation, and ensuring continuity of care when needed.
Timing Is Everything! Fertility Preservation Process From Patient Cancer Diagnosis Through Ovarian Tissue Cryopreservation to the Start of Treatment
Authors: Erickson Laura L. , Tsui Elizabeth L. , Laronda Monica M. 
Published: July 2022

AbstractChildren diagnosed with cancer today can expect a greater than 80% chance of 5-year survival. Childhood cancer survivors are significantly more likely to be infertile or have difficulty getting pregnant than their siblings. Studies have shown that infertility is one of the primary concerns of cancer survivors. Fertility preservation (FP) completed before treatment starts gives the patient the best fertility potential for a biological child in the future. Infertility is a significant risk factor for those treated with gonadotoxic therapy for cancer in childhood or adolescence. Infertility risk counseling and FP procedures may have the greatest success of fertility and hormone restoration if performed before the initiation of gonadotoxic therapy.A single-institution retrospective chart review was completed of patients enrolled in an institutional-review-board-approved ovarian tissue cryopreservation protocol from 2011 to 2019. Data collected include demographics and the timing of various stages of the FP process. One hundred five patients were included in this chart review (58 prepubertal and 47 postpubertal).Most consult requests were from the solid tumor diagnosis group. The time from diagnosis to consultation was 18 days, the time from consult to ovarian tissue cryopreservation surgery was 7 days, and the time from surgery to treatment was 5 days. Further investigation of time to consult revealed timing was justified in most patient situations.Workflow, education, and outreach were established. Future analyses will include defining the incidents and efficiencies in providing fertility and hormone consultations in female and male patients who do not undergo FP procedures.
The Effect of On-Site Visits From the Physical Therapy Clinical Instructor Perspective: A Mixed-Methods Approach
Authors: Palmer R. Joe , Rapport Mary Jane 
Published: July 2022

Introduction and Review of the Literature.
Strong academic–clinical partnerships are necessary to conduct effective, sustainable clinical education for entry-level physical therapy students. On-site visits are conducted by the entry-level physical therapist education program at affiliated clinical sites with identified clinical instructors. The purpose of this mixed-methods study was to explore the experience and impact on-site visits have on the academic–clinical partnership as perceived by physical therapy clinical instructors.

Subjects.
Participants were licensed physical therapists who have acted as a clinical instructor for at least 1 student from the study program. Ninety-five participants completed an anonymous survey and 14 participated in concurrent semi-structured interviews during the survey period.

Methods.
A concurrent, triangulation mixed-methods design was used to integrate quantitative and qualitative approaches in data analysis. A validated, novel survey was developed to assess perspectives of partnership using ordinary linear regression equations. A transcendental phenomenological approach explored perspectives of partnership after an on-site visit. The Partnership Success theoretical framework was used to define and frame the concept of partnership within this study.

Results.
Key findings showed that on-site visits demonstrated a statistically significant increase in perceptions of commitment among participants. On-site visits also appear to improve communication, result in stronger connections between the clinical site and physical therapist education program, and enhance resource sharing based on clinical instructor's interviews. Additionally, program alums demonstrate higher perceptions of trust and communication behaviors as compared with nonalums.

Discussion and Conclusion.
On-site visits are viewed favorably by clinical instructors who felt the visits positively contribute to the academic–clinical partnership and contribute to elements of the academic–clinical partnership, particularly in the area of perceived commitment. Program alums have different perceptions of partnership than nonalums.
Validation of a Very Brief Assessment of Interprofessional Collaborative Practice Skill Gains: ICCAS-Q21
Authors: Ohtake Patricia J. , Kruger Daniel J. , Kruger Jessica S. 
Published: July 2022

Introduction.
Assessing interprofessional education (IPE) learning experience effectiveness for developing interprofessional collaborative practice (IPCP) skill ability is important; however, current assessment measures pose considerable time burdens to respondents and learning experience logistics.

Review of Literature.
The Interprofessional Collaborative Competencies Attainment Survey (ICCAS) is a frequently used measure for self-assessed IPCP skill ability. The ICCAS instrument is administered after an interprofessional learning experience and uses a retrospective pretest/posttest design to assess 20 items and includes one additional item assessing overall skill gain (ICCAS-Q21). Although the total ICCAS score can reveal changes in IPCP abilities after an IPE learning experience, a brief measure may facilitate assessment with greater efficiency. The purpose of this investigation was to determine if the ICCAS-Q21 has the psychometric properties to serve as a stand-alone assessment instrument of self-assessed change in ability to perform the IPEC core competency skills.

Subjects.
Complete ICCAS scores were analyzed from 1,480 students from 12 different health professions programs (Fall 2019 [n = 807] and Spring 2020 [n = 673]).

Methods.
The ICCAS was completed after 2 in-person IPE forums. Total ICCAS pretest, posttest, and pretest–posttest difference (gain) scores were determined. Interprofessional Collaborative Competencies Attainment Survey interitem reliabilities were assessed, and Pearson correlations were conducted with ICCAS-Q21 and the total ICCAS pretest, posttest, and gain scores.

Results.
Total ICCAS scores increased after each IPE forum (P < .001). High internal consistency was observed among all items of the ICCAS. Interprofessional Collaborative Competencies Attainment Survey-Q21 was highly correlated with ICCAS gain scores (Fall r = .431, Spring r = .468; P < .001).

Discussion and Conclusion.
Interprofessional Collaborative Competencies Attainment Survey-Q21, a single-item assessment instrument, has psychometric properties that warrant its use to evaluate the self-assessed change in IPE core competency skill ability and is a good proxy for the full ICCAS instrument. This brief assessment instrument provides additional flexibility in assessment techniques for IPCP learning experiences.
Early recruitable coronary collaterals preserve miocardial viability in late presentation infarctions
Authors: Gutiérrez-Barrios Alejandro , Alarcón de la Lastra Inara , Cañadas-Pruaño Lola , Delgado William , Alba-Sáchez Miguel , Gamaza-Chulián Sergio , Díaz-Retamino Enrique , Zayas-Rueda Ricardo , Calle-Pérez Germán , Vázquez-García Rafael , Toro Rocio 
Published: July 2022

Background
Previous studies showed conflicting results regarding the contribution of coronary collateral circulation (CCC) to myocardial perfusion and function in the setting of myocardial infarction (MI). In the primary angioplasty era, the role of CCC in these studies may have been influenced by the effect of early reperfusion. The true impact of CCC could be clarified by studying its effect on nonreperfused patients. The aim of our study was to evaluate the effect of CCC on myocardial viability of late presentation MI.

Methods and results
Between 2008 and 2019, we included 167 patients with a late presentation MI who had a complete angiographic occlusion in a major coronary artery in which myocardial viability of the culprit territory was assessed. Patients were divided according to the presence of angiographic early recruited CCC (ERCC) (Rentrop 2–3) or poor CCC (PCC) (Rentrop 0–1). A lower left ventricular ejection function (LVEF) at discharge (54.2 ± 9 vs. 47.9 ± 12; <0.01) and a more severe left ventricular wall motion abnormalities in the culprit territory were observed in PCC patients. The presence of ERCC was the main independent predictor of myocardial viability in late presentation MI (hazard ratio, 4.24; 95% confidence interval, 1.68–10.6; P < 0.001). At follow-up, wall motion score increased significantly (2.05 ± 0.16; P = 0.02) in patients with ERCC but not in PCC patients (0.07 ± 0.16; P = 0.4), and LVEF improvement was significantly higher in ERCC than in PCC patients (9.7 ± 2.6 vs. 3.8 ± 4.2; P = 0.02).

Conclusion
The presence of ERCC was the main independent predictor of myocardial viability in late presentation MI.
Successful visible thrombus aspiration in ST-segment elevation myocardial infarction: associated factors and the clinical impact
Authors: Watanabe Tomomi , Akasaka Toshihiko , Kobara Satoshi , Yamamoto Kazuhiro 
Published: July 2022

Background
Thrombus aspiration (TA) has been considered a procedure for controlling distal emboli and improving microvascular perfusion. However, current guidelines classify routine TA as class III recommendation, and it has been reported that the efficacy of TA is limited because of the relatively high incidence of failure in retrieval of thrombotic material. The aim of this study was to explore patient characteristics and procedural factors associated with successful TA in ST-elevation myocardial infarction (STEMI) and to assess the clinical impact of successful TA.

Methods
This single-center retrospective study enrolled 158 STEMI patients who underwent TA as initial recanalization. Factors associated with successful TA, which was defined as retrieving any visible material by aspiration catheter, were explored, and angiographical and short-term outcomes were assessed.

Results
In 146 cases (92.4%), the aspiration catheter reached the culprit lesion. Successful TA was achieved in 72 cases (45.6%). The single angiographical characteristic of successful TA was a higher Thrombolysis in Myocardial Infarction grade before TA. Among the procedural characteristics, the rate of successful TA was higher with a 7-French aspiration catheter compared with the rate with a 6-French catheter (57.1% vs. 29.9%, P = 0.01). Thrombolysis in Myocardial Infarction grade 3 flow was more frequent in patients with successful TA immediately after TA (36.1% vs. 16.3%, P = 0.006) and at final angiography (91.7% vs 79.1%, P = 0.04) compared with the grade in patients without successful TA, respectively.

Conclusions
The use of a larger aspiration catheter may be effective in retrieving visible thrombus material, and successful TA led to better angiographical results.
Atherogenic index of plasma predicts coronary artery disease severity and major adverse cardiac events in absence of conventional risk factors
Authors: Mangalesh Sridhar , Yadav Paras , Dudani Sharmila , Mahesh Nalin Kumar 
Published: July 2022

Background
Various overlapping risk factors lead to coronary artery disease (CAD). The atherogenic index of plasma (AIP) is a marker for CAD severity and progression. However, little is known about its contribution to the residual risk of CAD observed in the absence of all typical risk factors.

Methods
A prospective cohort study of 366 Indian patients undergoing coronary computed tomography (CT) angiography and diagnosed with stable CAD. Diabetes, hypertension, hypercholesterolemia, smoking, previous CAD, alcohol or lipid-lowering medication intake, renal, liver or thyroid dysfunction were exclusion criteria. Coronary stenosis was graded using the CAD-reporting and data system (CAD-RADS™) system. Lipid profile, HbA1c, uric acid, highly sensitive C-reactive protein (hsCRP) and anthropometric measurements were taken. AIP, triglyceride/high-density lipoprotein cholesterol (HDLc) and total cholesterol (Tc)/HDLc ratios were calculated. Independent predictors of CAD severity and the occurrence of major adverse cardiac events (MACE) during 2.57 (0.52) years of follow-up were identified using logistic regression and Cox proportional hazards regression.

Results
Sixty patients experienced a MACE during a cumulative 887.03 person-years. HbA1c, uric acid, hsCRP, Tc/HDLc and AIP were independent predictors of severe coronary lesions (CAD-RADS 4,5) on multivariate analysis with odds ratio 4.52 (2.37–8.61), 1.41 (1.08–1.84), 1.33 (1.09–1.62), 1.76 (1.27–2.44) and 1.29 (1.11–1.50), respectively. Only AIP and Tc/HDLc were independent predictors of MACE with hazard ratios of 1.41 (1.20–1.65) and 1.78 (1.33–2.39) besides patient age and CAD severity.

Conclusion
AIP is associated with both the severity of CAD and the occurrence of MACE within 3 years. It could serve as an effective marker of residual risk of CAD in patients devoid of traditional risk factors. Lipid-profile ratios, such as AIP are cost-effective and accessible parameters suitable for low and middle-income settings.
Ultrasound Versus Computed Tomography–Guided Native Parenchymal Kidney Biopsies for Hospitalized Patients
Authors: Vu Tuan , Shin Benjamin , Mittal Anisha , Sarwani Nabeel , McGillen Kathryn L. 
Published: July 2022

Abstract
Percutaneous native kidney biopsies performed with ultrasound (US) or computed tomography (CT) guidance are important in the workup of medical renal disease, with modality choice often dependent on the performing institution, with various complication rates reported. We compared the complication rates and types of complication of US- versus CT-guided native parenchymal renal biopsy among hospitalized patients. One hundred five consecutive inpatient US- and CT-guided native parenchymal renal biopsies performed by radiologists at a tertiary care academic center between 2006 and 2020 were reviewed retrospectively. Complication rates of biopsy were calculated and compared between the 2 modalities. Comparisons with regard to types of complications were made using the Society of Interventional Radiology grading scale, American Society of Anesthesiologists score, and other clinical data. One hundred five hospitalized adult patients (58 women and 47 men; average age, 53 years) underwent native parenchymal kidney biopsy during the study period. Sixty-three (60%) were CT-guided and 42 (40%) were US-guided. Complication rates between CT- versus US-guided biopsies were 40% versus 19% (P = 0.03), respectively. There were 7 major and 18 minor complications for CT-guided biopsies and 3 major and 5 minor complications for US-guided biopsies. No statistically significant difference was found in preprocedural American Society of Anesthesiologists Classification score, international normalized ratio, platelet count, or body mass index. Computed tomography–guided native parenchymal kidney biopsy was associated with a higher overall complication rate compared with US-guided biopsy for hospitalized patients. Most complications were minor, which required no treatment or additional follow-up.
AFCOS: The Development of a Cryptoglandular Anal Fistula Core Outcome Set
Authors: Iqbal Nusrat , Astrid Machielsen J.H.M. , Merel L. Kimman , Gillian Kane , Rebecca Woodcock , Ugo Grossi , Phil J. Tozer , Stéphanie O. Breukink 
Published: July 2022

Objective:
To develop a cryptoglandular Anal Fistula Core Outcome Set: a minimum set of outcomes that should be measured in all studies of cryptoglandular anal fistula treatment.

Background:
Variability in the outcomes that are reported in studies of cryptoglandular anal fistula treatment hampers systematic evidence synthesis to identify the best treatment.

Methods:
This study followed guidance from the Core Outcome Measures in Effectiveness Trials initiative and consisted of three stages: (1) generation of candidate outcomes through systematic review of the literature and qualitative patient interviews; (2) prioritization of outcomes by key stakeholders, including patients, surgeons, gastroenterologists, and radiologists in an online Delphi consensus process; and (3) determination of the final Core Outcome Set (COS) in a consensus meeting attended by patients and clinicians.

Results:
Sixty-four outcomes were presented in the first Delphi survey round. A total of 191 participants from over 30 countries ranked these outcomes according to their importance in defining treatment success (57.6% surgeons and gastroenterologists, 8.9% radiologists, and 33.5% patients). After two rounds, 53 outcomes were identified as important and discussed in the consensus meeting attended by 10 patients and 12 clinicians. A final 10 outcomes were voted into the COS: clinical fistula healing, radiological healing, recurrence, development of additional fistulas, fistula symptoms, incontinence, psychological impact of treatment, complications and reinterventions, patient satisfaction, and quality of life.

Conclusion:
The final COS represents an international, multidisciplinary, patient-centered attempt to establish consistency in fistula research, with a substantial focus on patient priorities for treatment.
Home to Stay: A Randomized Controlled Trial Evaluating the Effect of a Postdischarge Mobile App to Reduce 30-Day Readmission Following Elective Colorectal Surgery
Authors: Pooni Aman , Brar Mantaj S. , Anpalagan Tharani , Schmocker Selina , Rashid Saira , Goldstein Rachel , Goriawala Alifiya , Easson Alexandra , Kennedy Erin D. 
Published: July 2022

Objective:
A randomized controlled trial was conducted to evaluate the effect of a postdischarge app on 30-day readmissions and patient-reported outcomes following colorectal surgery.

Background:
Patients undergoing colorectal surgery are particularly vulnerable during their transition from hospital-to-home. There has been increasing interest in e-health to provide cost-effective transitional care. An integrated discharge monitoring program using a mobile app platform was developed to support patients after surgery.

Methods:
A 2 arm, superiority randomized control trial was conducted at an academic tertiary care center with patients undergoing elective colorectal surgery. The intervention group received usual postoperative care and postdischarge monitoring with the app. The primary outcome was 30-day readmissions following hospital discharge.

Results:
Two hundred eighty-two participants were randomized. The majority were young, had inflammatory bowel disease and underwent laparoscopic surgery. Intention to treat analysis showed no difference between groups for 30-day readmission (14.8% vs 17.6%, P=0.55), ER visits (25.0% vs 28.8%, P=0.49), primary care visits (12.5% vs 8.8%, P=0.34) or unplanned healthcare visits (34.4% vs 35.2%, P=0.89). All patient reported outcomes were significantly improved with median scores higher with the app for satisfaction [9, interquartile range (IQR): 8–10 vs 8, IQR: 7–9, P=0.001], well-being (7, IQR: 6–8 vs 6, IQR: 5–7, P=0.001) and significantly lower for anxiety (3, IQR: 2–5 vs 5, IQR: 3–6, P=0.001).

Conclusions:
Although the app did not show a significant reduction in 30-day readmission or ER visits, it did lead to significant improvements in patient-reported outcomes. The app may be an important tool to support patients following colorectal surgery.
Identifying Persistent Opioid Use After Surgery
Authors: Fernandez Anne C. , Bohnert Amy , Gunaseelan Vidhya , Motamed Mehrdad , Waljee Jennifer F. , Brummett Chad M. 
Published: July 2022

Objective:
The present study assessed concordance in perioperative opioid fulfillment data between Michigan’s prescription drug monitoring program (PDMP) and a national pharmacy prescription database.

Background:
PDMPs and pharmacy dispensation databases are widely utilized, yet no research has compared their opioid fulfilment data postoperatively.

Methods:
This retrospective study included participants (N=19,823) from 2 registry studies at Michigan Medicine between July 1, 2016, and February 7, 2019. We assessed the concordance of opioid prescription fulfilment between the Michigan PDMP and a national pharmacy prescription database (Surescripts). The primary outcome was concordance of opioid fill data in the 91 to 180 days after surgical discharge, a time period frequently used to define persistent opioid use. Secondary outcomes included concordance of opioid dose and number of prescriptions fulfilled. Multinomial logistic regression analysis examined concordance across key subgroups.

Results:
In total, 3076 participants had ≥1 opioid fulfillments 91 to 180 days after discharge, with 1489 (49%) documented in PDMP only, 243 (8%) in Surescripts only, and 1332 (43%) in both databases. Among participants with fulfillments in both databases, there were differences in the number (n=239; 18%) and dose (n=227; 17%). The PDMP database was more likely to capture fulfillment among younger and publicly insured participants, while Surescripts was more likely to capture fulfillment from counties bordering neighboring states. The prevalence of persistent opioid use was 10.7% using PDMP data, 5.5% using Surescripts data only, and 11.7% using both data resources.

Conclusions:
The state PDMP appears reliable for detecting opioid fulfillment after surgery, detecting 2 times more patients with persistent opioid use compared with Surescripts.