bluuebunny/crossref_metadata_2025_split huggingface dataset:
Padrões de desfolha do milheto (Pennisetum americanum (L.) Leeke) pastejado por bezerras de corte
Authors: Monfardini Liana , Rocha Marta Gomes da , Rosa Vanessa Bayer da , Domingues Camille Carijo , Machado Juliana Medianeira , Rodrigues Dinah Pereira Abbott , Dotto Lisiani Rorato , Bergoli Tuani Lopes , Severo Paula de Oliveira , Pötter Luciana 
Published: November 2022

O trabalho foi realizado com o objetivo de avaliar a intensidade de desfolha, a taxa de retorno e as características estruturais do milheto (Pennisetum americanum (L.) Leeke) pastejado por bezerras de corte em dois estádios fenológicos dessa forrageira. Foi utilizado o método de pastejo com lotação contínua e número variável de animais para manter a altura do dossel entre 30 e 40 cm. O delineamento experimental utilizado foi o inteiramente casualizado com dois estádios fenológicos, vegetativo e pré-reprodutivo, com oito repetições de área. O número total de folhas foi 21,8% maior no estádio vegetativo. A densidade populacional de perfilhos basais (116,0/m²) e axilares (101,4 perfilhos/m²) foi semelhante nos estádios. A intensidade de desfolha média foi de 47% e a taxa geral de retorno foi de 5,6 dias. Cada bezerra pastejou uma área de 395,3 m²/dia. As lâminas foliares foram pastejadas 4,7 vezes durante a duração da vida da folha e o acúmulo térmico observado entre os intervalos de desfolha, foi suficiente para que 1,2 nova folha fosse emitida antes do próximo evento de desfolha. As bezerras mantiveram estratégia de pastejo similar durante os estádios avaliados com semelhante intensidade de desfolha e taxa de retorno das folhas expandidas e em expansão.
Tecnologia e inovação na pandemia da Covid-19: uma análise bibliométrica
Authors: Macêdo Tássia Teles Santana de , Palmeira Cátia Suely , Veras Nícolas Vinícius Rodrigues 
Published: November 2022

O presente artigo tem objetivo de analisar a produção científica brasileira referente à tecnologia e inovação aplicada a saúde na pandemia da COVID-19. Estudo bibliométrico que analisou as publicações nacionais, com destaque para os autores, instituições, periódicos, área de conhecimento, ano de publicação, e mapeamento da co-ocorrência das palavras-chave, registrados na base de dados Web of Science (WoS). Utilizou-se as palavras-chave: "Tecnologia”, “Inovação”, “Saúde” (nos idiomas português e inglês), “COVID-19”, “Coronavírus”, e “SARS-CoV-2”. A análise estatística descritiva compreendeu o período de 2019 e 2022, e teve suporte dos softwares Excel e VOSviewer. Os resultados desta pesquisa mostram que as publicações se concentraram no ano de 2021 (60,0%), na categoria Public Environmental Occupational Health da WoS (22,2%), nas universidades do Sudeste brasileiro, com destaque para a Universidade de São Paulo (22,5%), no periódico Revista da Sociedade Brasileira de Medicina Tropical (2,4%) e nos autores Giovanetti, M., Ciccozzi, M. & Durigon, E. L., sendo que esses autores juntos produziram mais 50 artigos publicados. No mapa de co-ocorrência foi possível identificar o conjunto de palavras-chaves que caracterizam o desenvolvimento da tecnologia e inovação à saúde durante a pandemia do COVID-19, com destaque o desenvolvimento de vacinas, terapias e testes de diagnóstico para enfrentamento da pandemia. Desta forma, conclui-se que a produção brasileira científica sobre tecnologia e inovação durante a pandemia COVID-19 foi produzida em artigos multidisciplinares e esteve voltada principalmente para à área de diagnóstico, tratamento e vacina. Entretanto, reforça a necessidade do avanço desses estudos com deferentes métodos no contexto discutido.
Rancang Bangun Sistem Monitring Dan Kontrol Pencampuran Nutrisi Dan Ph Air Pada Tanaman Hdiroponik Berbasis Internet Of Things
Authors: Rahman Ahmad Taufiqur , Herlina Amalia 
Published: November 2022

Hidroponik adalah membudidaya tanaman tanpa menggunakan tanah tetapi menggunakan air dan larutan nutrisi sebagai media tanam. Ada berbagai macam metode dalam pengairan nutrisi hidroponik, salah satunya. DFT (Deep Flow Technique) ialah salah satu sistem hidroponik yang menggunakan instalasi datar untuk membuat genangan air nutrisi pada instalasi.. Pada penelitian ini bertujuan untuk merancang Sistem Monitoring dan Kontrol Pencampuran Nutrisi dan pH air Pada Tanaman Hidroponik Berbasis Internet Of Things (IoT). Sistem kontrol yang digunakan mikrokontroller arduino uno dan aplikasi Blynk. Perancangan sistem ini meliputi perancangan hardware dan perancangan software untuk koneksi dengan aplikasi Blynk. Sistem ini dirancang menggunakan konsep internet of things dan dibuat menggunakan sensor TDS meter V1.0, pH-4502C, sensor Ultrasonik HC-SR04, Arduino Uno, relay 4 dan 2 Channel, LCD dan pompa dc. Kemudian hasil data yang hasilkan oleh sensor akan ditampilkan LCD dan aplikasi Blynk. Hasil penelitian ini dapat mengontrol dan memonitoring nilai PPM nutrisi, pH air dan ketinggian air nutrisi yang ada di bak penyimpanan nutrisi. Untuk pencampuran nutrisi akan mengikuti jadwal yang sudah di jadwalkan dan juga bisa menggunakan manual. Kemudian ketika PPM kurang dari 800 maka pompa dari larutan cairan pH up akan di campurkan, jika PPM lebih dari 1000 maka pompa dari cairan larutan pH down akan mencampurkan ke dalam penyimpanan bak penyimpanan nutrisi. Ketika nilai pH air kurang dari 6,0 maka pompa dari cairan larutan pH up akan dicampurkan, kemudian jika pH air lebih dari 7.0 maka pompa dari cairan larutan pH down akan dicampurkan ke dalam bak penyimpanan nutrisi.
Mapping Agricultural Biodiversity: Legacy data and tensions between ways of seeing fields
Authors: Craft Taylor B. , Beaulieu Anne , Piersma Theunis , Howison Ruth A. 
Published: November 2022

Mapping is a core approach used to investigate and display spatial dynamics of biological diversity and habitats. In the Netherlands, agricultural lands occupy nearly two-thirds of the land surface and provide the greatest potential for habitat restoration; particularly in grassland-based dairy production systems, which comprise the largest share of these agricultural lands. When a crop rotation is applied to a long-term grassland, the resulting disruption of ecological complexity requires years–if not decades–to restore, even after reconversion. The availability of high-quality land-use data for measuring the spatio-temporal distribution of grassland legacies is thus essential for monitoring the dynamics of biodiversity in production grasslands. In this study, we reflect on the Basic Crop Registration (BRP) of the Netherlands, an open spatial data infrastructure developed for parcel-level crop registration and examine how it shapes our spatio-temporal understanding of land use. The BRP serves as an administrative basis for numerous national and local-level regulatory and financial arrangements, mainly aimed at agricultural actors. In this study, we repurposed BRP data to introduce a new perspective on depicting the stability of grasslands in a high-intensity agricultural region. We used this data to map the frequency of grassland-to-cropland conversions using 17 years of longitudinal crop records in southwest Friesland, Netherlands. The legacy effects of grassland-to-cropland conversion were investigated in a field study, where significant differences were found between new and long-term grasslands in plant community composition, soil organic matter content, bulk density, soil penetration resistance, and pH. In our analysis of BRP data, we discovered a significant number of grasslands that were recently converted from cropland but that were recorded as long-term grasslands. This affected approximately 12% of the study area from 2005–2021, which prevents the accurate tracking of grassland stability over time. This misclassification also adds uncertainty to the temporal context of the decline in grassland-dependent species in the region. However, using a spatially-explicit mapping approach, these misclassifications can be corrected and help produce an effective measure of grassland stability with potential as an agroecosystem monitoring tool for researchers, land-use planners, and policymakers.
A panel of seven immune-related genes can serve as a good predictive biomarker for cervical squamous cell carcinoma
Authors: Dai Junshang , Pan Yuwen , Chen Yili , Yao Shuzhong 
Published: November 2022

Objective: Cervical cancer is one of the most common gynecological malignancies. The interaction between tumor microenvironment and immune infiltration is closely related to the progression of cervical squamous cell carcinoma (CSCC) and patients’ prognosis. Herein, a panel of immune-related genes was established for more accurate prognostic prediction.Methods: The transcriptome information of tumor and normal samples were obtained from TCGA-CSCC and GTEx. Differentially expressed genes (DEGs) were defined from it. Immune-related genes (IRGs) were retrieved from the ImmPort database. After removing the transcriptome data which not mentioned in GSE44001, IR-DEGs were preliminarily identified. Then, TCGA-CSCC samples were divided into training and testing set (3:1) randomly. Univariate Cox analysis, LASSO regression analysis and multivariate Cox analysis were used in turn to construct the signature to predict the overall survival (OS) and disease-free survival (DFS). External validation was performed in GSE44001, and initial clinical validation was performed by qRT-PCR. Function enrichment analysis, immune infiltration analysis and establishment of nomogram were conducted as well.Results: A prognostic prediction signature consisting of seven IR-DEGs was established. High expression of NRP1, IGF2R, SERPINA3, TNF and low expression of ICOS, DES, HCK suggested that CSCC patients had shorter OS (POS&lt;0.001) and DFS (PDFS&lt;0.001). AUC values of 1-, 3-, five- year OS were 0.800, 0.831 and 0.809. Analyses in other validation sets showed good consistency with the results in training set. The signature can serve as an independent prognostic factor for OS (HR = 1.166, p &lt; 0.001). AUC values of 1-, 3-, five- year OS based on the nomogram were 0.769, 0.820 and 0.807. Functional enrichment analysis suggested that these IR-DEGs were associated with receptor interaction and immune cell activity. Immune infiltration analysis indicated that patients in high-risk group had lower immune infiltration, weaker immune function, and were more likely to benefit from immune checkpoint inhibitor therapy. Through qRT-PCR on clinical samples, expression of NRP1, IGF2R, SERPINA3 and TNF were significantly upregulated in tumor tissue, while ICOS and DES were significantly downregulated.Conclusion: To conclude, the immune-related signature can provide strong support for exploration of immune infiltration, prediction of prognosis and response to immunotherapy through stratify CSCC patients into subgroups.
Identification of diagnostic genes for both Alzheimer’s disease and Metabolic syndrome by the machine learning algorithm
Authors: Li Jinwei , Zhang Yang , Lu Tanli , Liang Rui , Wu Zhikang , Liu Meimei , Qin Linyao , Chen Hongmou , Yan Xianlei , Deng Shan , Zheng Jiemin , Liu Quan 
Published: November 2022

BackgroundAlzheimer’s disease is the most common neurodegenerative disease worldwide. Metabolic syndrome is the most common metabolic and endocrine disease in the elderly. Some studies have suggested a possible association between MetS and AD, but few studied genes that have a co-diagnostic role in both diseases.MethodsThe microarray data of AD (GSE63060 and GSE63061 were merged after the batch effect was removed) and MetS (GSE98895) in the GEO database were downloaded. The WGCNA was used to identify the co-expression modules related to AD and MetS. RF and LASSO were used to identify the candidate genes. Machine learning XGBoost improves the diagnostic effect of hub gene in AD and MetS. The CIBERSORT algorithm was performed to assess immune cell infiltration MetS and AD samples and to investigate the relationship between biomarkers and infiltrating immune cells. The peripheral blood mononuclear cells (PBMCs) single-cell RNA (scRNA) sequencing data from patients with AD and normal individuals were visualized with the Seurat standard flow dimension reduction clustering the metabolic pathway activity changes each cell with ssGSEA.ResultsThe brown module was identified as the significant module with AD and MetS. GO analysis of shared genes showed that intracellular transport and establishment of localization in cell and organelle organization were enriched in the pathophysiology of AD and MetS. By using RF and Lasso learning methods, we finally obtained eight diagnostic genes, namely ARHGAP4, SNRPG, UQCRB, PSMA3, DPM1, MED6, RPL36AL and RPS27A. Their AUC were all greater than 0.7. Higher immune cell infiltrations expressions were found in the two diseases and were positively linked to the characteristic genes. The scRNA-seq datasets finally obtained seven cell clusters. Seven major cell types including CD8 T cell, monocytes, T cells, NK cell, B cells, dendritic cells and macrophages were clustered according to immune cell markers. The ssGSEA revealed that immune-related gene (SNRPG) was significantly regulated in the glycolysis-metabolic pathway.ConclusionWe identified genes with common diagnostic effects on both MetS and AD, and found genes involved in multiple metabolic pathways associated with various immune cells.
Anticardiolipin and/or anti-β2-glycoprotein-I antibodies are associated with adverse IVF outcomes
Authors: Wu Li , Fang Xuhui , Lu Fangting , Zhang Yu , Wang Yanshi , Kwak-Kim Joanne 
Published: November 2022

ObjectiveThe purpose of the study is to evaluate the effects of anticardiolipin (aCL) and/or anti-β2-glycoprotein-I (aβ2GPI) antibodies, namely antiphospholipid antibodies (aPL), on in vitro fertilization (IVF) outcomes.Materials and methodsThe study group comprised infertile women with aPL undergoing IVF-ET cycles. Controls were infertile women with tubal etiology without aPL. The impact of aPL on reproductive outcomes, such as oocyte quality, embryo quality, and implantation capacity, was compared between the study group and controls. Additionally, peripheral blood T cell subsets, such as T helper (Th)1, Th2, Th17, and T regulatory (Treg) cells and cytokines, were analyzed by the flow cytometry. Differences between the study group and controls were analyzed.ResultsA total of 132 infertile women, including 44 women with aPL, and 88 controls were sequentially recruited for this study. Women with aPL had lower numbers of total and perfect/available embryos and lower rates of MII oocytes, blastocyst formation, perfect and available embryos, implantation, clinical pregnancy, and take-home baby. Additionally, imbalanced Th1/Th2 and Th17/Treg ratios, significantly higher levels of serum IL-2, TNF-α, IFN-γ, and IL-17A, and a significantly lower serum IL-4 were noticed in women with aPL compared to controls.ConclusionWomen with aPL such as aCL and/or aβ2GPI antibodies were associated with adverse IVF outcomes. Early screening for aPL and appropriate consultation for couples undergoing IVF should be considered. In addition, underlying immunopathology and inflammatory immune mechanisms associated with aPL should be further explored.
Effect of estuarine dam location and discharge interval on estuarine hydrodynamics, sediment dynamics, and morphodynamics
Authors: Figueroa Steven M. , Son Minwoo , Lee Guan-hong 
Published: November 2022

The effect of an estuarine dam located near the mouth for a range of estuarine types (strongly stratified, partially mixed, periodically stratified, and well-mixed) has been studied using a numerical model of an idealized estuary. However, the effect of different dam locations and freshwater discharge intervals has not yet been studied. Here, models were run for each estuary type with dam locations specified at x = 20, 55, and 90 km upstream from the mouth, and discharge intervals specified as once every Δt = 0.5, 3, and 7 days. The hydrodynamic, sediment dynamic, and morphodynamic results for the pre- and post-dam estuaries were analyzed to understand changes in estuarine processes. It was found that the estuarine dam altered the tide and river forcing in turn altering the stratification, circulation, sediment fluxes, and depths. The estuarine dam location primarily affected the tide-dominated estuaries, and the resonance length was an important length scale affecting the tidal currents and Stokes return flow. When the location was less than the resonance length, the tidal currents and Stokes return flow were most reduced due to the loss of tidal prism, the dead-end channel, and the shift from mixed to standing tides. The discharge interval primarily affected the river-dominated estuaries, and the tidal cycle period was an important time scale. When the interval was greater than the tidal cycle period, notable seaward discharge pulses and freshwater fronts occurred. Dams located near the mouth with large discharge interval differed the most from their pre-dam condition based on the estuarine parameter space. Greater discharge intervals, associated with large discharge magnitudes, resulted in scour and seaward sediment flux in the river-dominated estuaries, and the dam located near the resonance length resulted in the greatest landward tidal pumping sediment flux and deposition in the tide-dominated estuaries.
Stent-alone treatment of unruptured vertebral artery fusiform aneurysms: A comparison of flow diverter and conventional stents
Authors: Li Wenqiang , Zhu Wei , Wang Yanmin , Zhao Yapeng , Wang Yang , Liu Xianzhi , Zhang Yisen 
Published: November 2022

BackgroundTreatment of vertebral artery fusiform aneurysms (VAFAs) is complex and controversial. This study aimed to compare the safety and efficacy between flow diverter and conventional stents in patients with VAFAs undergoing endovascular stent-alone treatment (SAT).MethodsThirty-six patients with 36 VAFAs who underwent SAT between January 2014 and December 2018 were retrospectively analyzed. Patient and aneurysm characteristics, procedural details, complications, and angiographic and clinical outcomes were compared between flow diverter stent patients (n = 22) and conventional stent patients (n = 14).ResultsMore branches covered with stent were found in the conventional stent group (88.9 vs. 33.3%; p = 0.008). The number of stents placed was significantly higher in the conventional stent group (1.57 ± 0.76 vs. 1.09 ± 0.29; p = 0.016). The proportion of patients with significant or moderate stasis within the aneurysm immediately after stent placement was higher in the flow diverter stent group (95.5 vs. 57.1%; p = 0.004). The proportion of patients with complete obliteration or only a residual neck on follow-up angiography was significantly higher in the flow diverter stent group (86.3 vs 50.0%; p = 0.047). However, the incidence of parent artery stenosis or occlusion was also higher in the flow diverter stent group (27.3% vs. zero; p = 0.032). The rate of complications did not significantly differ between the groups.ConclusionsSAT was safe and effective in patients with VAFAs. Flow diverter stents are associated with a significantly better complete occlusion rate than conventional stents; however, they are also associated with an increased risk of parent artery stenosis.
Vestibular evoked myogenic potential may predict the hearing recovery in patients with unilateral idiopathic sudden sensorineural hearing loss
Authors: Liang Min , Wu Hui , Chen Jianyong , Zhang Qin , Li Shuna , Zheng Guiliang , He Jingchun , Chen Xiangping , Duan Maoli , Yang Jun , Jin Yulian 
Published: November 2022

ObjectiveThis study investigates the association between vestibular function and prognosis in patients with unilateral idiopathic sudden sensorineural hearing loss (UISSNHL).DesignA retrospective analysis of 64 patients with UISSNHL was performed. Pure tone audiometry and vestibular function tests for otoliths and semicircular canals were performed to assess the influence of vestibular functional status on the outcome of patients with UISSNHL.ResultsPatients with abnormal cervical vestibular evoked myogenic potential (cVEMP) or ocular vestibular evoked myogenic potential (oVEMP) responded less favorably to treatment. In the ineffective group, cVEMP was normal in four patients (6.3%) and oVEMPs in three (4.7%). Meanwhile, cVEMP was abnormal in 32 patients (50.0%) and oVEMP in 33 (51.6%). Better hearing recovery occurred in those with normal cVEMP (33.76 ± 15.07 dB HL improvement) or oVEMP (32.55 ± 19.56 dB HL improvement), but this was not the case in those with normal caloric tests. Patients with abnormalities in both cVEMP and oVEMP were less responsive to treatment and had worse hearing recovery than those with normal results in only one of the two tests.ConclusionAbnormal oVEMP and/or cVEMP results indicate poor auditory outcomes in patients with UISSNHL. Patients with impaired otolith organ function are likely to have a larger and more severe pathological change in their inner ear.
Impact of time between thrombolysis and endovascular thrombectomy on outcomes in patients with acute ischaemic stroke
Authors: Wagner Lora , Mohrbach Desiree , Ebinger Martin , Endres Matthias , Nolte Christian H. , Harmel Peter , Audebert Heinrich J. , Rohmann Jessica L. , Siegerink Bob 
Published: November 2022

BackgroundBenefits of endovascular thrombectomy (ET) after intravenous thrombolysis (IVT) for patients with acute ischaemic stroke (AIS) have been demonstrated, but analyses of the relationship between IVT-ET time delay and functional outcomes among patients receiving both treatments are lacking.MethodsWe used data from the “Berlin—Specific Acute Treatment in Ischaemic and haemorrhAgic stroke with Long-term outcome” (B–SPATIAL) registry. Between January 1st, 2016 and December 31st, 2019, we included patients who received both IVT and ET. The primary outcome was the 3-month ordinal modified Rankin scale (mRS) score. The IVT-ET time delay was analyzed in categories and continuously. We used adjusted ordinal logistic regression to estimate common odds ratios (cOR) and 95% confidence intervals (CI). Secondary analyses involved flexible modeling of IVT-ET delay and dichotomous outcomes.ResultsOf 11,049 patients, 714 who received IVT followed by ET were included. Compared with having an IVT-ET window &gt;120 min (reference), for an IVT-ET window &lt; 30 min, we obtained adjusted cORs for mRS of 0.41 (95% CI: 0.22 to 0.78); and 0.52 (95% CI: 0.33 to 0.82) for 30 to 120 min. Secondary analyses also found protective effects of shorter time delays against “poor” functional outcomes at 3 months.ConclusionsIn patients with AIS, shorter IVT-ET intervals were associated with better 3-month functional outcomes. While the time-to-IVT and time-to-ET include the time until medical attention is received, the IVT-ET time delays fall entirely within the domain of medical management and thus might be easier to optimize.