bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone Remodeling in an Mps-1h Girl after Hematopoietic Stem Cell
Transplantation along with Enzymatic Replacement Therapy
Authors: Tummolo Albina , Brunetti Giacomina , Piacente Laura , Marzollo Antonio , Biffi Alessandra , Burlina Alberto , Faienza Maria Felicia 
Published: May 2022

Background:
Mucopolysaccharidosis-1H (Hurler syndrome, MPS-1H) is the most
severe form of a lysosomal storage disorder (LSD) caused by variants in IDUA, encoding alpha-
L-iduronidase (IDUA). MPS-1H is also associated with various degrees of skeletal defects due
to the accumulation of partially degraded glycosaminoglycans (GAGs) in the lysosomes of
connective tissue cells. The efficacy of hematopoietic stem cell transplantation (HSCT) and
enzymatic replacement therapy (ERT) on MPS-1H skeletal manifestations is still considered
unsatisfactory.

Case presentation:
We report the case of a young girl, who manifested significant changes in
bone remodeling markers and osteoclastogenesis potential after HSCT combined with ERT. She
received ERT and underwent two HSCTs. The skeletal alterations at the time of diagnosis showed
a trend toward improvement of both mobility and radiological features after HSCT. We observed
the highest levels of Receptor activator of nuclear factor-kappa-Β ligand (RANKL) and
RANK/osteoprotegerin (OPG) ratio at diagnosis and during ERT, consistently with spontaneous
osteoclastogenesis. Conversely, after the successful HSCT with ongoing ERT, the highest levels
of osteocalcin were observed and all markers of bone formation and resorption improved.

Conclusion:
The combination therapy of ERT and HSCT was effective in reducing osteoclast
activity and increasing osteoblast activity, and these changes were according to the child's bone
phenotype, IDUA activity, and Glycosaminoglycan (GAG) trends. These results represent one of
the few pieces of human evidence in this context.
Toxicity, Genotoxicity, and Carcinogenicity of Isotretinoin
Authors: Yilmaz Serkan 
Published: May 2022

Background:
Acne is a chronic inflammatory disease mainly observed in adolescence,
but it can also be seen during the neonatal, infantile, pre-pubertal, and adult periods.
Isotretinoin (13-cis-retinoic acid) is a first-generation retinoid and is the most effective treatment
for acne vulgaris.

Objective:
The present study has been systematically designed to figure out the toxic, genotoxic,
and carcinogenic activities of isotretinoin.

Methods:
In this study, a systematic approach was followed by focusing on the possible links
between these topics. The search of the databases was carried out author in accordance with
the guidelines of the Centre for Reviews and Dissemination (2009) developed by York University
National Institute of Health Research. The search was concentrated on the Web of Science,
PubMed, Science Direct, Scopus, EBSCO Host, and Google Scholar databases.

Results:
Isotretinoin was found as a toxic agent in all studies. All researchers proposed that
apoptosis is the only pathway of adverse effects of isotretinoin. However, genotoxicity, teratogenicity,
and carcinogenicity information of isotretinoin is very limited and controversial.

Conclusion:
More detailed studies need to clarify the genotoxic and carcinogenic potential of
isotretinoin. Patients should be informed correctly, the risks of treatment should be explained,
and awareness should be raised.
Cellulose Supported Propylamine/Molybdate Complex: A Novel and
Recyclable Nanocatalyst for the Synthesis of Pyranopyrimidine Derivatives
Authors: Farahi Mahnaz , Keshavarz Raziyeh 
Published: May 2022

Background:
Carbon-based materials, due to their unique properties such as lightweight,
different forms, doping capability with hetero atoms, low cost, and ease of processability,
are suitable support, for heterogeneous catalysts. Among them, cellulose, as one of the most abundant
and renewable organic polymers, preserves a key position in many organic raw materials.
Pyranopyrimidine derivatives, due to their high biological activity are of interest to both medicinal
chemists and biochemists. Moreover, they play the most fundamental structural role in many natural
compounds and are medicinally useful molecules. Owing to the great variety of biologically
active pyridines, it is not surprising that the pyridine ring system has become a vital basic component
in many pharmaceutical agents.

Method:
In this study, cellulose as a heterogeneous support was used to prepare an efficient solid
catalyst. Cellulose, as the most abundant organic polymer, is a suitable material for this purpose.
Then, by immobilizing polyoxomolybdate by a linker on the surface of this carbon-based material,
we succeeded in producing Cell@(CH2)3N=Mo[Mo5O18] nanocatalyst. The structure and properties
of this catalyst were confirmed by various analyses including FT-IR, XRD, EDS-map, FESEM,
and TGA, and its efficacy was evaluated by its use in the preparation of Pyrano[2,3-
d]pyrimidine derivatives through a multicomponent reaction between aryl aldehydes, malononitrile,
and barbituric acid.

Results:
The results of this study showed that this new and non-toxic organo-inorganic hybrid
nanocatalyst provides the desired products in a short time and with appropriate efficiency.

Conclusion:
The key features of the present protocol include reusability of the catalyst, ease of
recovery, ambient reaction conditions, and simple work-up procedure that make it economic and
sustainable.
Shwasananda Vati, a South Indian Traditional Herbo-Mineral Formulation:
Insights on the Proposed Biological Roles, Safety, and Therapeutic
Profile
Authors: Kumar T. Sanath , Sharma Rohit , Shrilata  , Kumar Dileep 
Published: May 2022

Abstract:
Shwasananda vati (SV) is a South Indian traditional herbo-mineral formulation widely
used in different parts of southern India, particularly in Kerala state. The formulation is documented
in an ancient Kerala traditional treatise and is widely used as a treatment for respiratory ailments in
both children and adults. The formulation is cited in an ancient Kerala traditional treatises and significantly
used as a remedy for respiratory ailments in children as well as adults. The composition
comprises herbs and mineral which is categorized under poisonous drugs (schedule E (1) drugs) as
per Ayurvedic Indian traditional system of medicine. However, in Ayurveda, herbo-mineral drugs
are purified or detoxified before being used for therapeutic purposes. Ayurveda doctrines consider
these herbo-mineral medications to have unique attributes such as instant effectiveness, the requirement
of a very small dosage, and a wide range of therapeutic utility. The compliance data on the
safety and efficacy of this formulation or its ingredients is scarce. To place traditional medicine on a
scientific footing, a thorough knowledge of SV, its therapeutic potential, safety, and toxicity profile,
supported by scientific evidence, is necessary. The present report analyses the role of this traditional
preparation, highlighting traditional therapeutic claims, possible bioactivities, safety profile, and
therapeutic potential as per current assumptions of science.
Dyslipidemia Secondary to the Use of HAART in Adults: A Systematic
Review
Authors: Couto Ricardo David , Oliveira Diogo Pereira Rodrigues , Macêdo Ana Paula Azevêdo , dos Santos Gonçalves Mariane 
Published: May 2022

Background:
HIV infection affects millions of people globally. Currently, although
several drugs have brought an improvement in the quality and life expectancy of these individuals,
they are accompanied by several adverse effects.

Objective:
To conduct a systematic review of studies examining the relationship between antiretroviral
therapy (ART) uses and secondary dyslipidemia.

Methods:
The review followed the criteria defined by PRISMA. Only articles that completely
evaluated the lipid profile were included, which consisted of total cholesterol (TC), triglycerides
(TG), and LDL cholesterol (LDL-c), HDL cholesterol (HDL-c).

Results:
It was observed that the use of nucleoside and non-nucleoside reverse transcriptase inhibitor
(NNRTI and NNRTI respectively) drugs and protease inhibitors are the most used in ART and
are associated with changes in lipid profiles. The main changes observed were increases in TC,
TG, and LDL-c in addition to a decrease in HDL-c. These patients had a higher risk of developing
cardiovascular disease not only due to the use of therapy, but also due to the presence of other
comorbidities evaluated in these studies, such as obesity, diabetes, and hypertension. The increase
in age, the difference between genders, CD4 T-cell count, and viral load, were observed as risk
factors for worsening dyslipidemia.

Conclusion:
According to the findings of this study, anti-HIV therapy is linked to dyslipidemia,
which may or may not be the primary cause, and is frequently connected with a number of metabolic
problems that can exacerbate the illness.
Effects of Two Modes of Groups Counseling Approaches on HIV
Voluntary Counseling and Testing Among School-going Adolescents
Authors: Lawrence Kehinde Clement , Elizabeth Osita Egbule 
Published: May 2022

Aims:
The study investigated the effects of cognitive behavioral and reality group therapies in fostering human immunodeficiency virus/ voluntary counseling and testing among school-going adolescents in Benin Metropolis, Edo State, Nigeria.

Method:
A pre- and post-test true experimental control group design was observed. While 120 school-going adolescents from three randomly selected schools were recruited and randomly assigned to two treatments (Cognitive Behavior [37] and Reality [34] Therapies) and control [38] groups, with 11 dropout accounting for 9% alteration rate. The treatment last six weeks. Two hypotheses were formulated to guide the study. The instruments used for data collection were self-administered scales with a test-retest reliability coefficient of 0.87 after an interval of three weeks. Data generated was analyzed using the inferential statistics of Analysis of Variance tested at a 0.05 level of significance.

Results:
The results showed that cognitive behaviour and reality therapies were significantly effective in fostering HIV/voluntary counselling and testing among school-going adolescents. That is, the two modes of group interventions improve the willingness of adolescents of these schools towards receiving counselling and performing testing for HIV.

Conclusion:
It was concluded that cognitive behaviour and reality therapies were found to be potent on school-going adolescents’ willingness toward HIV voluntary counselling and testing for prevention and treatment.
Anti-coronaviral Activity of Plant and Seaweed Secondary Metabolites: A
Review
Authors: Ülger Taha Gökmen , Yılmaz Serkan , Çakıroğlu Funda Pınar , Uçar Aslı 
Published: May 2022

Background:
Coronavirus Disease 2019 (COVID-19), one of the greatest challenges facing
humanity, continues to affect millions of people worldwide. Vaccines approved and authorized for use are
effective against COVID-19, but viral variants of concern may emerge in the near future. The discovery
of novel antiviral agents will help humanity overcome COVID-19 and aid in any future viral pandemics.

Objective:
This review aimed to evaluate evidence from the plant- and seaweed-derived secondary compound-
based interventions for viral diseases caused by coronaviruses.

Methods:
A comprehensive search of several databases, including Cochrane Library, Web of Science and
PubMed was conducted to identify available studies evaluating the outcomes of plant- and seaweed secondary
metabolites in viral diseases such as Severe Acute Respiratory Syndrome, Middle East Respiratory
Syndrome and COVID-19.

Results:
The volume of existing reports is irrefutable evidence that some plant- and seaweed-derived
secondary compounds (e.g., mannose-specific lectins, griffithsin, cyanovirin-N, gallate, curcumin, luteolin,
quercetin and betulinic acid) possess a potential antiviral ability against coronaviruses, including
SARS-CoV-2.

Conclusion:
Plant and seaweed secondary metabolites with antiviral activity show their activity in different
metabolic pathways. Besides reducing and preventing the metabolic damage caused by proinflammatory
cytokines and oxidative stress, several plants and seaweed secondary metabolites can also be effective
in improving some clinical indexes specific to COVID-19. Despite their effectiveness in preclinical
studies, plant and seaweed-derived secondary compounds need more pharmacokinetic studies and safety
measures concerning their mitogenic and allergenic properties.
Using songs to promote the affective domain in learning listening of EFL students
Authors: Melisa Melisa , Silviyanti Tgk Maya , Syamaun Arifin 
Published: May 2022

This qualitative study principally aimed to discover how songs can be used to promote students' affective domain in listening class activities. One English teacher and twenty-five 8th-grade students of a public junior high school in Greater Aceh, Indonesia, were involved in this study. The data were collected through classroom observation. This present study followed Krathwohl, Bloom, and Masia’s (1973) five observation criteria of the affective domain framework. Subsequently, the teacher and four selected students were interviewed for additional data. The results demonstrated that songs have a positive impact on students' affective domain. Students become enthusiastic about learning listening skills. They listened well and remembered the title of the new song (receiving phenomenon); actively participated in the classroom activities (responding phenomenon); demonstrated their problem-solving ability by working together (valuing); and effective time management (organization). Despite their ability to cooperate in group activities, they had no self-reliance when working individually (internalizing values). However, the students agree that the classroom environment was more comfortable and enjoyable. The results of the study suggest that teachers should consider using songs to not only teaches the knowledge but also the culture associated with the song itself when it comes to teaching listening. Aside from the cognitive aspects, teachers should also maintain and track students' progress in the affective domain.
Emergency remote teaching during COVID-19 crisis: An analysis of EFL students’ engagement in Aceh
Authors: M. Amin Fakhrurrazi , Zulfitri Zulfitri 
Published: May 2022

To prevent the spread of the coronavirus (Covid-19) and its pandemic, emergency remote teaching must be implemented. This has brought significant problems and difficulties for students due to this unusual circumstance, EFL students must learn to adapt their abilities. Because of the widespread use of technology in education, the quick transition to complete online learning necessitates some adjustment. EFL students must be able to handle online learning that is performed through technology integration and utilizing technological tools they have never used before in a short period of time. In response to emergency remote teaching, this study examined how engaged EFL students are, as well as their perceptions of such engagement. One hundred ninety-one students from four state Islamic universities in Aceh filled out an online questionnaire adapted from McColskey (2012). Both descriptive and thematic methods were used to analyze the data. EFL students demonstrated their level of engagement in all three categories of engagement: behavioral, emotional, and cognitive engagement. Positive responses and feelings of satisfaction were shown during emergency remote teaching. It indicates that EFL students have a better grasp of how to use technology in education. It is essential to constantly enhance their skills and have enough equipment and infrastructure to facilitate online learning.
Did Accrual Earnings Management Decline and Real Earnings Management Increase Post-SOX? A Re-Examination Over an Extended Post-SOX Period and A Closer Look at REM-AEM Substitution
Authors: Pincus Morton , Wu Shijia , Hwang Jasper 
Published: May 2022

ABSTRACT
A widely cited paper, Cohen, Dey, and Lys (2008, hereinafter CDL), examines accrual (AEM) and real earnings management (REM) pre- and post-Sarbanes Oxley and provides evidence that, in the period immediately following SOX, accruals management declined and was substituted by REM. We re-visit CDL and ask whether CDL's main results extend to recent periods and hold using updated research design choices. We find AEM declines in the period immediately after SOX, but the results are sensitive to some design choices. We also find AEM generally declines over our entire extended post-SOX period, suggesting that the components of SOX were largely successful in constraining AEM. REM is higher post-SOX but with an insignificant trend over the entire extended post-SOX period. Additionally, the results indicate REM and AEM behave as substitutes in the period preceding SOX, but the substitution effect significantly weakens post-SOX.
Do High-Quality Auditors Improve Non-GAAP Reporting?
Authors: Feng Zhuoan , Francis Jere R. , Shan Yaowen , Taylor Stephen L. 
Published: May 2022

ABSTRACT
Prior research finds that clients of high-quality auditors report higher-quality GAAP earnings. We extend this research to investigate whether auditor quality is associated with the quality of voluntarily disclosed non-GAAP earnings measures. Using a sample of Australian firms disclosing annual non-GAAP metrics, we find that clients of high-quality auditors are more likely to voluntarily disclose non-GAAP earnings numbers. However, clients of high-quality auditors make adjustments in calculating non-GAAP earnings (non-GAAP exclusions) that are less predictive of future earnings and less value relevant than those of other firms. These results indicate that their adjustments are of higher quality. We also find similar results for U.S. firms using a sample of quarterly non-GAAP earnings disclosures. Overall, our evidence indicates that commonly used indicators of audit quality for GAAP reporting are positively associated with the quality of voluntarily disclosed non-GAAP earnings measures.
JEL Classifications: J33; M41.
DESAIN DAN PERANCANGAN MINIATUR ALAT PENYARING SAMPAH OTOMATIS BERBASIS PLC
Authors: Alfaresi Bengawan , Afandi  , Ardianto Feby 
Published: May 2022

Penyelesaian masalah sampah yang menumpuk pada aliran selokan diperkotaan merupakan masalah yang sering terjadi dan membuat suatu bencana yang sulit teratasi dengan baik. Peningkatan masyarakat membuang sampah di selokan lngkungan sekitar membuat terjadinya penumpukan sampah pada selokan yang tidak diimbangi dengan pengambilan dan pengolahan sampah. Tujuan pada penelitian adalah membuat dan merancang prototipe alat pemungut sampah selokan menggunakan PLC yang dioperasikan secara otomatis untuk mengurangi tenaga manusia dan lebih mengefisienkan waktu dalam pemungutan sampah diselokan yang terus menumpuk. Metode yang diterapkan pada penelitian ini yaitu mengunakan metode pencakaran sampah. Alat pemungutan sampah ini mulai bekerja dari pemungutan sampah yang dibawa oleh konveyor 1 yang selanjutnya dijatuhkan ke konveyor 2 dan sampah yang terbawa konveyor 2 akan di jatuhkan ke wadah sampah. Alat pemungutan sampah ini di operasikan oleh push button pada box panel. Hasil dari penelitian kecepatan pemungutan sampah pada konveyor 1 bisa dibagi menjadi 3 kategori yaitu cepat, sedang dan lambat. Untuk kategori cepat dengan dengan 250 Rpm bisa memungut 75 sampah apung dengan waktu 37,8 detik, persentase kegagalan mencapai 6,7%. Untuk kategori sedang dengan 125 Rpm bisa memungut 75 sampah apung dengan waktu 48,6 detik dengan persetase kegagalan pungut 8% dan terakhir untuk kategori kecepatan lambat bisa memungut 75 sampah apung dengan waktu 78,8 detik dengan persentase kegagalan pungut 9,3%. Kesimpulan dari penelitian ini semakin cepat putaran maka tingkat kegagalan semakin kecil yaitu 6.7% dan waktu yang dibutuhkan akan semakin cepat dengan waktu 37.8 detik per 75 sampah.
Analisis Traction Power Supply Substation LRT Palembang
Authors: Apriani Yosi , Zaelani Imron 
Published: May 2022

Adanya penambahan Highway Light Rail Transit (LRT) maka menyebabkan beban Traction Power Supply Substation (TPSS) semakin bertambah karena jarak antar LRT dalam perjalanan kereta yang semakin rapat. Dengan sistem ini maka jumlah tarikan daya LRT pada setiap keberangkatan di setiap stasiun meningkat yang berakibat naiknya beban arus listrik pada gardu. Tujuan penelitian ini adalah menganalisis kemampuan tiap-tiap gardu listrik untuk mengetahui berapa besar jumlah kebutuhan daya listrik sesuai dengan pola operasi TPSS serta untuk mengetahui berapa besar jumlah kebutuhan daya listrik LRT Metode penelitian ini adalah: 1. Study literatur, 2. Pengumpulan data, 3. Simulasi menggunakan ETAP, 4. Perbandingan kapasitas perhitungan dengan kapasitas eksisting, 5. Analisis. Berdasarkan hasil perhitungan kapasitas daya yang tersedia dalam keadaan per LRT Asrama Haji yaitu sebesar 1339 kW pada lintas Puntikayu yaitu 1142 kW dan sebesar 653 kW pada lintas Demang, kapasitas daya yang tersedia sebesar 4141 kW. Persentase daya terpakai tertinggi sebesar 32,3% sehingga kapasitas daya yang tersedia masih mencukupi untuk memenuhi kebutuhan beban berdasarkan daya eksisting.
RANCANG BANGUN SISTEM PROTEKSI OVERHEATING MESIN DAN PEMANTAU TEGANGAN AKI PADA MOBIL
Authors: Ahmad Yuvi Utomo  
Published: May 2022

Abstract -- Overheating is one of the causes of damage or decreased performance on the vehicle. This can occur due to a lack of water in the radiator or a radiator leak. Generally, overheating occurs in vehicles manufactured before 2000 because they do not have protection or warning in case of excessive temperature. Vehicles with production years before 2000 usually only have a temperature indicator in the form of a pointer with a scale. In addition to overheating, the voltage on the battery cannot be monitored due to the absence of a battery voltage reader so that the battery experiences under-voltage or overvoltage caused by damage to the charging system in the battery. Based on these problems, a tool is made to prevent overheating and prevent damage to the battery. In this tool, the DS18b20 sensor is used to determine the temperature that occurs in the vehicle engine, while the battery voltage information is obtained using a voltage divider circuit. The results of the temperature and voltage sensors are processed using the Arduino Nano Microcontroller to obtain information about the engine temperature and battery voltage. The processing results are displayed using an OLED LCD and the output is connected to two relays, one relay for automatic fans and one relay for vehicle ignition. The results showed that this tool can turn on and turn off the fan automatically, and can cut off the ignition of the vehicle based on the temperature of the radiator water. This tool provides a warning if the battery voltage is above or below the normal voltage. With this tool, overheating of the engine and damage to the battery can be prevented.
Keywords -- Overheating, protection, temperature