bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Penggunaan Celebrity Instagram Endorser Terhadap Keputusan Pembelian Pada Bisnis Online Di Kota Bandung
Authors: Julian Arsy , Novalia Nidya , Mursyidah Desta Sulaesih 
Published: December 2022

In the online era like today, Indonesians prefer to buy and sell products through social media. Instagram is widely used to promote products. Consumer purchasing decisions are very important to be reviewed by the company because it will have an impact on the survival of the company. One important aspect is the Instagram celebrity endorser. The purpose of this study was to determine the effect of using celebrity instagram endorser on purchasing decisions in online businesses in Bandung. The place of research was conducted at Mayoutfit Bandung. This research is a quantitative descriptive study with simple linear regression analysis. The data collection technique is through the distribution of questionnaires distributed to Mayoutfit consumers who use Instagram. The data analysis technique is done by validity and reliability test, descriptive test, classic assumption test, normality test, simple linear regression test, hypothesis test and test coefficient of determination. This study shows the influence of Instagram celebrity endorser on consumer purchasing decisions. Suggestions for future research and practical suggestions will be presented further.
Keywords: Celebrity endorser, Instagram, Onlineshop, Purchase Decision
Efektivitas Gel Tepung Cacing Tanah (<i>Lumbricus rubellus</i> Hoff.) Sebagai Penyembuh Luka Sayat Pada Mencit (<i>Mus muscullus</i> L.)
Authors: Harlis Wa Ode , Nasaruddin Nasaruddin , Nurhasana Nurhasana , Resman Resman 
Published: December 2022

Cuts are wounds that occur due to being cut by a sharp instrument. Earthworms (Lumbricus rubellus Hoff.) contain antibacterial compounds, arachidonic acid and proteins that help the growth of skin tissue. The formulation in the form of a gel is easier to use and has soothing, moisturizing properties, and easily penetrates the skin so that it provides a healing effect. This study aims to determine the effect of earthworm flour gel on wound healing in mice (Mus muscullus L.). This type of research is an experimental study with a completely randomized design (CRD). A total of 20 male mice were divided into 5 groups, namely positive control (Kalmicetine 10%), negative control (without treatment), K1 (earthworm flour gel concentration 3%), K2 (earthworm flour gel concentration 4%) and K3 (earthworm flour gel with a concentration of 4%). earthworm flour 5% concentration). The results showed that the average length of time for wound healing for each group was 11.75 days or 282 hours for a 3% concentration, 11.25 days or 270 hours for a 4% concentration, and 11 days or 264 hours for a 5% concentration, compared to positive control (Kalmicetine). 10%) 12 days or 288 hours and negative control for 14 days or 336 hours. The results of the study concluded that earthworm (Lumbricus rubellus Hoff.) flour gel was effective in accelerating the healing of cuts.Keywords: Cuts, Lumbricus rubellus, gelAbstrakLuka sayat adalah luka yang terjadi karena teriris oleh instrument yang tajam. Cacing tanah (Lumbricus rubellus Hoff.) mengandung senyawa antibakteri, asam arakidonat dan protein yang membantu pertumbuhan jaringan kulit. Formulasi dalam bentuk gel lebih mudah digunakan dan mempunyai sifat yang menyejukan, melembabkan, dan mudah berpenetrasi pada kulit sehingga memberikan efek penyembuhan. Penelitian ini bertujuan untuk mengetahui pengaruh gel tepung cacing tanah terhadap penyembuhan luka sayat pada mencit (Mus muscullus L.). Jenis penelitian adalah penelitian eksperimental dengan metode rancangan acak lengkap (RAL). Sebanyak 20 ekor mencit jantan dibagi dalam 5 kelompok yaitu kontrol positif (Kalmicetine 10%), kontrol negatif (tanpa perlakuan), K1 (gel tepung cacing tanah konsentrasi 3%), K2 (gel tepung cacing tanah konsentrasi 4%) dan K3 (gel tepung cacing tanah konsentrasi 5%). Hasil penelitian menunjukkan bahwa rerata lama waktu penyembuhan luka setiap kelompok adalah 11,75 hari atau 282 jam untuk konsentrasi 3%, 11.25 hari atau 270 jam untuk konsentrasi 4%, dan 11 hari atau 264 jam untuk konsentrasi 5%, dibandingkan kontrol positif (Kalmicetine 10%) 12 hari atau 288 jam dan kontrol negatif selama 14 hari atau 336 jam. Hasil penelitian disimpulkan bahwa gel tepung cacing tanah (Lumbricus rubellus Hoff.) efektif dalam mempercepat penyembuhan luka sayat.Kata Kunci: Luka sayat, Lumbricus rubellus, gel
The effect of Online Costumer Reviews and Influencer Marketing on Shopee Purchasing Decisions
Authors: Muhammad Fachmi  , Sinau Hasriani 
Published: December 2022

The purpose of this research id to determine the partial and simultaneous effect of the variables studied. In this research using quantitative research approach with a sample number of 99 students with multiple regression analysis methodes spss aplikasi assistance 25. This research was conducted at (Case Study of Undergraduate Students) STIE Amkop Makassar. The purpose of this research shows that from the results of data management using the SPSS 25 application, it is known that that there is a positive and significant effect of online customer review on purcashing decision, and so is partial teasting of influencer marketing on meaningful perfomance of positive and significant effect, while simultaneous testing shows that online customer review and influencer marketing have a positive and significant effect on perfomance
Deep learning and session-specific rapid recalibration for dynamic hand gesture recognition from EMG
Authors: Karrenbach Maxim , Preechayasomboon Pornthep , Sauer Peter , Boe David , Rombokas Eric 
Published: December 2022

We anticipate wide adoption of wrist and forearm electomyographic (EMG) interface devices worn daily by the same user. This presents unique challenges that are not yet well addressed in the EMG literature, such as adapting for session-specific differences while learning a longer-term model of the specific user. In this manuscript we present two contributions toward this goal. First, we present the MiSDIREKt (Multi-Session Dynamic Interaction Recordings of EMG and Kinematics) dataset acquired using a novel hardware design. A single participant performed four kinds of hand interaction tasks in virtual reality for 43 distinct sessions over 12 days, totaling 814 min. Second, we analyze this data using a non-linear encoder-decoder for dimensionality reduction in gesture classification. We find that an architecture which recalibrates with a small amount of single session data performs at an accuracy of 79.5% on that session, as opposed to architectures which learn solely from the single session (49.6%) or learn only from the training data (55.2%).
IL-15 induced bystander activation of CD8+ T cells may mediate endothelium injury through NKG2D in Hantaan virus infection
Authors: Zhang Xiyue , Zhang Yusi , Liu He , Tang Kang , Zhang Chunmei , Wang Meng , Xue Manling , Jia Xiaozhou , Hu Haifeng , Li Na , Zhuang Ran , Jin Boquan , Zhang Fanglin , Zhang Yun , Ma Ying 
Published: December 2022

IntroductionHantaan virus (HTNV) can cause endothelium injury in hemorrhagic fever with renal syndrome (HFRS) patients. Bystander activation of CD8+ T cells by virus infection has been shown that was involved in host injury, but it is unclear during HTNV infection. This project aimed to study the effect of bystander-activated CD8+ T cell responses in HTNV infection.MethodsThe in vitro infection model was established to imitate the injury of endothelium in HFRS patients. Flow cytometry was performed to detect the expression of markers of tetramer+ CD8+ T cells and human umbilical vein endothelial cells (HUVECs). The levels of interleukin-15 (IL-15) in serum and supermanant were detected using ELISA kit. The expression of MICA of HUVECs was respectively determined by flow cytometry and western blot. The cytotoxicity of CD8+ T cells was assessed through the cytotoxicity assay and antibody blocking assay.ResultsEBV or CMV-specific CD8+ T cells were bystander activated after HTNV infection in HFRS patients. HTNV-infected HUVECs in vitro could produce high levels of IL-15, which was positively correlated with disease severity and the expression of NKG2D on bystander-activated CD8+ T cells. Moreover, the elevated IL-15 could induce activation of CD122 (IL-15Rβ)+NKG2D+ EBV/CMV-specific CD8+ T cells. The expression of IL-15Rα and ligand for NKG2D were upregulated on HTNV-infected HUVECs. Bystander-activated CD8+ T cells could exert cytotoxicity effects against HTNV-infected HUVECs, which could be enhanced by IL-15 stimulation and blocked by NKG2D antibody.DiscussionIL-15 induced bystander activation of CD8+ T cells through NKG2D, which may mediate endothelium injury during HTNV infection in HFRS patients.
Soluble tumor endothelial marker 1 in heart failure with reduced ejection fraction: A pilot study
Authors: Feng Wen-Han , Chen Po-Sheng , Chung Hsing-Chun , Lin Yi-Hsiung , Li Yi-Heng 
Published: December 2022

BackgroundTumor endothelial marker 1 (TEM1/CD248) is a transmembrane protein that expresses in mesenchymal lineage derived cells during embryogenesis and becomes undetectable in normal adults after birth. Re-expression of TEM1 is found in organ fibrosis, wound healing and cardiac remodeling indicating its potential role in heart failure (HF). The purpose of this study is to explore the role of soluble TEM1 (sTEM1) in patients with HF with reduced ejection fraction.MethodsWe examined endomyocardial biopsy specimens from three HF patients and blood samples from 48 patients admitted for acute decompensated HF (age 72 years, men 61.7%). The expression of TEM1 in cardiac tissue and concentrations of sTEM1 in plasma were evaluated. Cultured rat cardiomyocytes (H9c2) and human cardiac fibroblasts (HCF) were stimulated with hypoxia or transforming growth factor beta (TGF-β) to observe the release of sTEM1 into culture media. The conditioned media of hypoxia-stimulated H9c2 cells was harvested and added into cultured cardiac fibroblast to evaluate its biological effect.ResultsImmunofluorescence study of biopsy specimens from three HF patients showed TEM1 expression in cardiomyocytes and cardiac fibroblasts. The plasma level of sTEM1 was significantly higher in patients (0.90 ± 0.23 vs. 0.33 ± 0.10 ng/mL, p = 0.032) with LVEF ≤ 35% compared with those with LVEF 36–49%. The sTEM1 levels had correlations with HF biomarkers of cardiac fibrosis, including growth differentiation factor-15 (GDF-15) and galectin-3. There was a significant increase in sTEM1 levels in the cultured media of H9c2 and HCF after being stressed with hypoxia or TGF-β. The conditioned media derived from hypoxia-stimulated H9c2 cells significantly increased cell proliferation of cardiac fibroblasts. This effect was partially reversed by anti-TEM1 antibody.ConclusionThis pilot study demonstrated that cardiac TEM1 expression was upregulated in HF. The levels of sTEM1 were significantly higher in HF patients with LVEF ≤ 35% and correlated with other biomarkers of cardiac fibrosis. In vitro study proved that functional sTEM1 was released into cultured media after stressing cardiomyocytes and HCF.
Apply pressure-strain loop to quantify myocardial work in pulmonary hypertension: A prospective cohort study
Authors: Wang Jian , Ni Chao , Yang Menghui , Zhang Xueming , Ruan Binqian , Sun Lingyue , Shen Xuedong , Shen Jieyan 
Published: December 2022

ObjectivesPressure-strain loop (PSL) is a novel method to quantify myocardial work in many cardiovascular diseases. To investigate the value of myocardial work parameters derived from PSL for evaluating cardiac function and clinical prognosis in patients with pulmonary hypertension (PH).MethodsA total of 52 patients with PH and 27 healthy controls were enrolled in this prospective study. PSLs determined by echocardiography were used to calculate global work index (GWI) of left ventricle (LV) and right ventricle (RV). Global constructive work (GCW) comprised the sum of myocardial work performed during shortening in systole and during lengthening in isovolumic relaxation. Global wasted work (GWW) comprised the sum of myocardial work performed during lengthening in systole and during shortening in isovolumic relaxation. Global work efficiency (GWE) was defined as GCW/(GCW + GWW).ResultsLVGWW, RVGWI, RVGCW and RVGWW were significantly higher in patients than controls (all P &lt; 0.001). LVGWE, LVGWI, LVGCW, and RVGWE were lower in patients than controls (all P &lt; 0.01). Myocardial work parameters correlated well with clinical and other conventional echocardiographic assessments (all P &lt; 0.05). In binary logistic regression analysis, the combination of RVGWE and estimation of pulmonary arterial systolic pressure (ePASP) was the best model to predict clinical outcomes (OR = 0.803, P = 0.002 and OR = 1.052, P = 0.015, respectively). Receiver operating characteristic curv demonstrated the combination of RVGWE and ePASP was the best predictor of adverse events with 100% sensitivity and 76.3% specificity (AUC = 0.910, P &lt; 0.001).ConclusionMyocardial work parameters derived from PSL are emerging markers of cardiac function. And the combination of RVGWE and ePASP is a useful predictor of clinical outcome in PH patients.
Novel and emerging therapies in pulmonary arterial hypertension
Authors: Cassady Steven J. , Soldin Danielle , Ramani Gautam V. 
Published: December 2022

Pulmonary arterial hypertension (PAH), defined as a mean pulmonary artery pressure exceeding 20 mmHg with a pulmonary vascular resistance of 3 or more Wood units, is an incurable and progressive condition. The cornerstone of PAH treatment is pulmonary vasodilators, which act on the pulmonary vasculature to reduce pulmonary pressures and pulmonary vascular resistance and prevent progression to right heart failure. The number of available pulmonary vasodilator therapies has grown markedly in the last 10 years, alongside a rapidly expanding body of literature establishing strategies for their use. Up-front combination therapy, typically with two pulmonary vasodilator medications, has become the standard of care based on landmark trials showing superior outcomes over single therapies alone. Complex risk stratification matrices have begun to see widespread use as tools with which to guide changes in PAH therapies for individual patients. Strategies for using the pulmonary vasodilators in common use continue to be evaluated in trials exploring concepts such as up-front triple combination therapy and substitution of vasodilators for patients not meeting therapeutic goals. Alongside established pulmonary vasodilator therapies for PAH, there is a broad spectrum of experimental therapies that are being studied for the disease. These include both more conventional medications that act on pathways targeted by existing vasodilator therapies as well as non-vasodilator treatments with novel methods of action, that may act both to vasodilate and to address the detrimental changes of pulmonary arterial and right ventricular remodeling. Many of these emerging medications are the focus of active phase 2 and 3 trials. Finally, there has been significant interest in therapeutic pathways that are well established in left heart failure, with the hope of adapting strategies that may be efficacious in PAH and right heart failure as well. These include explorations of pathways treated by goal-directed medical therapy as well as device therapies such as pacing, resynchronization therapy, and cardiac monitoring devices. Many of these options show promise and may represent a complementary approach to treatment of PAH, allowing for multimodal therapy alongside pulmonary vasodilators to improve patient outcomes.
Overview of global publications on machine learning in diabetic retinopathy from 2011 to 2021: Bibliometric analysis
Authors: Shao An , Jin Kai , Li Yunxiang , Lou Lixia , Zhou Wuyuan , Ye Juan 
Published: December 2022

PurposeTo comprehensively analyze and discuss the publications on machine learning (ML) in diabetic retinopathy (DR) following a bibliometric approach.MethodsThe global publications on ML in DR from 2011 to 2021 were retrieved from the Web of Science Core Collection (WoSCC) database. We analyzed the publication and citation trend over time and identified highly-cited articles, prolific countries, institutions, journals and the most relevant research domains. VOSviewer and Wordcloud are used to visualize the mainstream research topics and evolution of subtopics in the form of co-occurrence maps of keywords.ResultsBy analyzing a total of 1147 relevant publications, this study found a rapid increase in the number of annual publications, with an average growth rate of 42.68%. India and China were the most productive countries. IEEE Access was the most productive journal in this field. In addition, some notable common points were found in the highly-cited articles. The keywords analysis showed that “diabetic retinopathy”, “classification”, and “fundus images” were the most frequent keywords for the entire period, as automatic diagnosis of DR was always the mainstream topic in the relevant field. The evolution of keywords highlighted some breakthroughs, including “deep learning” and “optical coherence tomography”, indicating the advance in technologies and changes in the research attention.ConclusionsAs new research topics have emerged and evolved, studies are becoming increasingly diverse and extensive. Multiple modalities of medical data, new ML techniques and constantly optimized algorithms are the future trends in this multidisciplinary field.
Joint analysis of m6A and mRNA expression profiles in the testes of idiopathic nonobstructive azoospermia patients
Authors: Tang Qiuqin , Wu Wei , Lu Yiwen , Zhou Yijie , Wu Wangfei , Li Jinhui , Pan Lianjun , Ling Xiufeng , Pan Feng 
Published: December 2022

BackgroundGrowing evidence has indicated that epigenetic factors might be associated with the pathophysiology of idiopathic nonobstructive azoospermia (iNOA). As the most common RNA modification, N6-methyladenosine (m6A) methylation has recently attracted more attention in the regulation of spermatogenesis; however, its role in the mechanisms of iNOA is still unclear.ObjectiveTo determine the differential expression of mRNA and m6A methylation status in the testes of iNOA patients.MethodsTestes tissues from diagnosed iNOA and controlled obstructive azoospermia (OA) patients were collected and grouped according to the histological examinations. Total RNA was isolated and quantified by an m6A RNA Methylation Quantification Kit. The expression level of mRNAs was detected by qRT-PCR analysis. Differentially expressed m6A genes were analyzed using the human ArrayStar m6A epitranscriptomic microarray, and bioinformatics analyses were applied.ResultsA total of 36 iNOA and 8 controlled patients were included. The global expression of m6A in the iNOA group was significantly decreased. A dosage relationship was observed between the m6A decline and the degree of impaired spermatogenesis, with the successive process of normal spermatogeneis, hypospermatogenesis (HP), maturation arrest (MA), and Sertoli cell-only syndrome (SO). Four down-expressed genes (BDNF, TMEM38B, RPL3L, and C22orf42) displayed significantly lower expression of m6A methylation. Additionally, they also showed a gradually down-expressed tendency in the three groups (OA, HP, SO/MA groups). Moreover, m6A reader EIF3A was approved to have differential expression through microarrays analysis, which was consistent with the result from the qRT-PCR test.ConclusionsThe m6A expression was gradually downregulated in the testes tissue from iNOA patients in accordance with the degree of spermatogenic dysfunction. The determined differential expression of mRNA and m6A methylation status may represent potentially novel molecular targets for the mechanism study of iNOA in the epigenetic level, which could benefit the understanding of the pathophysiology of iNOA.
Comparison the effects of finerenone and SGLT2i on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus: A network meta-analysis
Authors: Li Xuefeng , Wu Hongli , Peng Huifang , Jiang Hongwei 
Published: December 2022

BackgroundFinerenone and sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been shown to improve cardiovascular and renal outcomes in patients with type 2 diabetes mellitus (T2DM), while the relative efficacy has not been determined.MethodsThe databases of PubMed, Embase and Cochrane were searched for relevant cardiovascular or renal outcome trials of SGLT2i or finerenone. The end points were major adverse cardiovascular events (MACE), nonfatal stroke (NS), myocardial infarction (MI), hospitalization for heart failure (HHF), cardiovascular death (CVD), and renal composite outcome (RCO). Network meta-analysis was performed using Bayesian networks to obtain pooled hazard ratios (HR) and 95% confidence intervals (CI). The probability values for ranking active and placebo interventions were calculated using cumulative ranking curves.Results1024 articles were searched, and only 9 studies were screened and included in this meta-analysis with 71793 randomized participants. Sotagliflozin (HR 0.72 95%CI 0.59-0.88, SUCAR=0.93) and canagliflozin (HR 0.80 95%CI 0.67-0.97, SUCAR=0.73) can significantly reduce the risk of MACE compared with placebo. Canagliflozin (HR 0.64 95%CI 0.48-0.86, SUCAR=0.73), sotagliflozin (HR 0.66 95%CI 0.50-0.87, SUCAR=0.69) and empagliflozin (HR 0.65 95%CI 0.43-0.98, SUCAR=0.68) can significantly reduce the risk of HHF compared with placebo. Empagliflozin (HR 0.62 95%CI 0.43-0.89, SUCAR=0.96) can significantly reduce the risk of CVD compared with placebo. Empagliflozin (HR 0.61 95%CI 0.39-0.96, SUCAR=0.74), canagliflozin (HR 0.66 95%CI 0.46-0.92, SUCAR=0.63), and dapagliflozin (HR 0.53 95%CI 0.32-0.85, SUCAR=0.88) can significantly reduce the risk of RCO compared with placebo. Finerenone has reduced the risk of MACE, MI, HHF, CVD and RCO to varying degrees, but they do not show significant difference from placebo and each SGLT2i.ConclusionBoth SGLT2i and finerenone could reduce the risk of MACE, HHF, MI, CVD, RCO. Finerenone has no obvious advantage than SGLT2i on the effects of cardiovascular and renal protective.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022375092.