bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote monitoring in patients with heart failure with cardiac implantable electronic devices: a systematic review and meta-analysis
Authors: McGee Michael J , Ray Max , Brienesse Stepehn C , Sritharan Shanathan , Boyle Andrew J , Jackson Nicholas , Leitch James W , Sverdlov Aaron L 
Published: November 2022

BackgroundRemote monitoring (RM) of cardiac implantable electronic devices (CIEDs) is now the standard of care, but whether the demonstrated benefits of RM translate into improvements in heart failure (HF) management is controversial. This systematic review addresses the role of RM in patients with HF with a CIED.Methods and resultsA systematic search of the literature for randomised clinical trials in patients with HF and a CIED assessing efficacy/effectiveness of RM was performed using MEDLINE, PubMed and Embase. Meta-analysis was performed on the effects of RM of CIEDs in patients with HF on mortality and readmissions. Effects on implantable cardiac defibrillator (ICD) therapy, healthcare costs and clinic presentations were also assessed.607 articles were identified and refined to 10 studies with a total of 6579 patients. Implementation of RM was not uniform with substantial variation in methodology across the studies. There was no reduction in mortality or hospital readmission rates, while ICD therapy findings were inconsistent. There was a reduction in patient-associated healthcare costs and reduction in healthcare presentations.ConclusionRM for patients with CIEDs and HF was not uniformly performed. As currently implemented, RM does not provide a benefit on overall mortality or the key metric of HF readmission. It does provide a reduction in healthcare costs and healthcare presentations.PROSPERO REGISTRATION NUMBERCRD42019129270.
$$M_W$$, dark matter and $$a_\mu $$ in the NMSSM
Authors: Domingo Florian , Ellwanger Ulrich , Hugonie Cyril 
Published: November 2022

AbstractWe study regions in the parameter space of the NMSSM which are able to simultaneously explain the current measured values for the W mass $$M_W$$

M
W

and the muon anomalous magnetic moment $$a_\mu $$

a
μ

, and provide a dark matter relic density consistent with the observations as well as constraints from detection experiments. The corresponding regions feature light charginos and sleptons in the 100 GeV–1 TeV range, at least some of them with masses below 175 GeV such such that the electroweakly-interacting SUSY particles generate sufficiently large contributions to $$M_W$$

M
W

. The LSP is always singlino-like with a mass below 150 GeV, and could possibly remain invisible even at future detection experiments. Decays of electroweak sparticles proceed through cascades via staus and/or sleptons which makes their detection challenging. We propose benchmark points for future searches of such sparticles. The lightest CP-even scalar may have a mass in the 95–98 GeV range with, however, modest signal rates in view of the mild excesses reported in this range at LEP and by CMS at the LHC.
Research on the detection of early caries based on hyperspectral imaging
Authors: Wang Cheng , Zhang Haoying , Lai Guangyun , Hu Songzhu , Wang Jun , Zhang Dawei 
Published: November 2022

Objective: We applied hyperspectral imaging (HSI) system to distinguish early caries from sound and pigmented areas. It will provide a theoretical basis and technical support, for research and development of an instrument that could be used for screening and detection of early dental caries. Methods: Eighteen extracted human teeth (molars and premolars), with varying degrees of natural pathology and no degree of decay involving dentin were obtained. HSI system with a wavelength range from 400 to 1000[Formula: see text]nm was used to obtain images of all 18 teeth containing sound, carious and pigmented areas. We compared the spectra of the wavebands at both 500[Formula: see text]nm and 780[Formula: see text]nm from the different tooth states, and the reflectance difference between sound versus carious lesions and sound versus pigmented areas, respectively. Results: There was a slight difference in reflectance between carious areas and pigmented areas at 500[Formula: see text]nm. A substantial difference was additionally noted in reflectance between carious areas and pigmented areas at 780[Formula: see text]nm. Conclusion: The results have shown that the interference of tooth surface pigment can be eliminated in the near-infrared (NIR) waveband, and the caries can be effectively identified from the pigmented areas. Thus, it could be used to detect carious areas of teeth in place of the traditional visual inspection method or white light endoscopy. Clinical significance: The NIR diffused light signal enables the identification of early caries from pigment and other interference, providing a reasonable detection tool for early detection and early treatment of teeth diseases.
Chapter 9. Application of sequence stratigraphy to the evaluation of selected North Sea Jurassic hydrocarbon fields and carbon capture, utilization and storage (CCUS) projects
Authors: Copestake Philip 
Published: November 2022

Abstract
The application of sequence stratigraphic concepts and methods augments the efficient development of North Sea hydrocarbon fields with Jurassic reservoirs. In particular, the approach provides enhancements to the development of robust reservoir zonations, more accurate assessments of the extent and continuity of reservoir zones and flow units, clearer identification and prediction of the most productive reservoir intervals, improved understanding of field-wide pressure barriers or baffles to fluid flow, and enhanced reservoir models. In addition, carbon capture and storage (CCS) projects in Jurassic rocks will benefit from the adoption of a sequence stratigraphic approach by enhancing the understanding of storage unit architecture, connectivity and top seals. In this chapter, these applications are discussed with reference to around 20 case studies from the North Sea Basin.
Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Authors: Milutinovic Stefan , Abe Jun , Jones Emma , Kelch Inken , Smart Kathryn , Lauder Sarah N. , Somerville Michelle , Ware Carl , Godkin Andrew , Stein Jens V. , Bogle Gib , Gallimore Awen 
Published: November 2022

High endothelial venules (HEV) are specialized post capillary venules that recruit naïve T cells and B cells into secondary lymphoid organs (SLO) such as lymph nodes (LN). Expansion of HEV networks in SLOs occurs following immune activation to support development of an effective immune response. In this study, we used a carcinogen-induced model of fibrosarcoma to examine HEV remodeling after depletion of regulatory T cells (Treg). We used light sheet fluorescence microscopy imaging to visualize entire HEV networks, subsequently applying computational tools to enable topological mapping and extraction of numerical descriptors of the networks. While these analyses revealed profound cancer- and immune-driven alterations to HEV networks within LNs, these changes did not identify successful responses to treatment. The presence of HEV networks within tumors did however clearly distinguish responders from nonresponders. Finally, we show that a successful treatment response is dependent on coupling tumor-associated HEV (TA-HEV) development to T-cell activation implying that T-cell activation acts as the trigger for development of TA-HEVs which subsequently serve to amplify the immune response by facilitating extravasation of T cells into the tumor mass.Significance:We used three-dimensional imaging methods with computational tools to analyze networks of specialized blood vessels called HEVs in LNs and tumors. By applying these techniques in a mouse model of carcinogen-induced tumors, we could identify network changes after depletion of Tregs.
Subverting Aristotelianism through Aristotle
Authors: Zaffino Valentina 
Published: November 2022

Abstract
This paper examines whether Giordano Bruno’s philosophy should be considered pantheist or immanentist—two philosophies that scholars regard as partly equivalent. However, this paper distinguishes them and argues that Bruno either identified the whole of nature with God or recognized a primary principle that is immanent, yet distinguishable, from matter. In terms of Bruno’s interpretation of the Aristotelian notions of form and matter, the difference between an immanentist view and a pantheist one lies in the role that form (or act) assumes with regard to matter (or potency). This paper maintains that Bruno interpreted and adapted Aristotle’s philosophy to find his own immanentist metaphysics, which is built on the traditional Aristotelian system. This argument was based on the reconstruction of how he used Aristotelian thought as an instrument to subvert Aristotelianism. In particular, Bruno attested that intellect exists within nature, but it is not co-extensive with the whole nature. Finally, the paper highlights how Bruno applied Aristotle’s language, method, and themes to criticize the fundamentals of Aristotelian philosophy and the related traditions.
Pharmacogenomic Testing for Major Depression: A Qualitative Study of the Perceptions of People with Lived Experience and Professional Stakeholders
Authors: Slomp Caitlin , Morris Emily , Edwards Louisa , Hoens Alison M. , Landry Ginny , Riches Linda , Ridgway Lisa , Bryan Stirling , Austin Jehannine 
Published: November 2022

Objectives With increasing evidence for the clinical utility of pharmacogenomic (PGx) testing for depression, there is a growing need to consider issues related to the clinical implementation of this testing. The perspectives of key stakeholders (both people with lived experience [PWLE] and providers) are critical, but not frequently explored. The purpose of this study was to understand how PWLE and healthcare providers/policy experts (P/HCPs) perceive PGx testing for depression, to inform the consideration of clinical implementation within the healthcare system in British Columbia (BC), Canada. Methods We recruited two cohorts of participants to complete individual 1-h, semi-structured interviews: (a) PWLE, recruited from patient and research engagement networks and organizations and (b) P/HCPs, recruited via targeted invitation. Interviews were audiotaped, transcribed verbatim, de-identified, and analysed using interpretive description. Results Seventeen interviews were completed with PWLE (7 with experience of PGx testing for depression; 10 without); 15 interviews were completed with P/HCPs (family physicians, psychiatrists, nurses, pharmacists, genetic counsellors, medical geneticists, lab technologists, program directors, and insurers). Visual models of PWLE's and P/HCP's perceptions of and attitudes towards PGx testing were developed separately, but both were heavily influenced by participants’ prior professional and/or personal experiences with depression and/or PGx testing. Both groups expressed a need for evidence and numerous considerations for the implementation of PGx testing in BC, including the requirement for conclusive economic analyses, patient and provider education, technological and clinical support, local testing facilities, and measures to ensure equitable access to testing. Conclusions While hopeful about the potential for therapeutic benefit from PGx testing, PWLE and P/HCPs see the need for robust evidence of utility, and BC-wide infrastructure and policies to ensure equitable and effective access to PGx testing. Further research into the accessibility, effectiveness, and cost-effectiveness of various implementation strategies is needed to inform PGx testing use in BC.
Microscope-assisted pneumatic retinopexy for the management of primary rhegmatogenous retinal detachment
Authors: Besozzi Gianluca , Montericcio Alessio , Costa Maria Carmela , Nitti Giuseppe , Parolini Barbara , Giancipoli Ermete , Greggio Angelo , Tozzi Luigi , Gius Irene , Frisina Rino 
Published: November 2022

Purpose Outcomes of pneumatic retinopexy (PnR) using surgical microscope, wide-angle viewing system, and chandelier endoilluminator (microscope-assisted pneumatic retinopexy) for primary rhegmatogenous retinal detachment (RRD) Methods Retrospective study. 43 consecutive eyes with RRD undergoing microscope-assisted PnR surgery (MAPR) were analysed. Inclusion criteria comprehend phakic eyes with single retinal break or a group of breaks in detached retina in the same quadrant above 8- and 4-o’clock meridians. Follow-up was at least 6 months. Results Of the 43 eyes, a total of 25 (58%) presented preoperatively a single retinal break, 15 (35%) had two retinal breaks in the same quadrant and 3 (7%) presented three or more retinal breaks in the same quadrant. Other retinal breaks not observed preoperatively were discovered intraoperatively in 12 eyes (28%). In 9 (21%) the missed retinal breaks were in the same quadrant as the main diagnosed break(s), while 3 (7%) had missed retinal breaks in a different one. These 3 eyes as no longer adhering to the PnR indication criteria switched intraoperatively to other surgical procedures and were excluded in the reattachment rate results. The total primary reattachment rate with MAPR was achieved in 37 eyes (92.5%). No significant BCVA changes were observed postoperatively. Conclusion MAPR is an effective and safe surgical option, it allows to work with both hands free and provides an adequate visualization of the retina during the procedure minimizing the risk of missed retinal breaks potentially leading to surgical failure.
Impairments in Emotion Recognition and Positive Emotion Regulation Predict Social Difficulties in Adolescent With ADHD
Authors: McKay Erin , Cornish Kim , Kirk Hannah 
Published: November 2022

Background Emotional dysregulation, poor emotion recognition and impaired response inhibition have been highlighted as potential contributors to social difficulties in adolescents with attention-deficit/hyperactivity disorder (ADHD). It is currently unknown how these areas of impairment relate to one another; therefore, this study aims to identify the areas of emotion regulation which are associated with social difficulties in adolescents with ADHD, and determine whether emotion regulation mediates the relationship between deficits in response inhibition and emotion recognition, and social functioning, in this cohort. Methods Thirty Australian adolescents (Male = 21) with ADHD completed measures of response inhibition, emotion recognition, and emotion regulation. Results Positive emotion regulation was significantly associated with social difficulties. Although emotion recognition significantly predicted social difficulties, there was no relationship between emotion recognition and emotion regulation in this sample, ruling out emotion regulation as a mediator of emotion recognition and social difficulties. Whilst response inhibition was significantly correlated with positive emotion regulation, positive emotion regulation did not mediate the relationship between response inhibition and social difficulties. Conclusions Difficulties recognising and regulating emotions appear to independently contribute to social difficulties in adolescents with ADHD. Interventions to increase emotional understanding and developing strategies to down-regulate positive emotions may be beneficial.
Systemic immune-inflammation index for predicting poor outcome after carotid endarterectomy: A novel hematological marker
Authors: Yuksel Ahmet , Velioglu Yusuf , Korkmaz Ufuk Turan Kursat , Deser Serkan Burc , Topal Dursun , Badem Serdar , Taner Temmuz , Ucaroglu Erhan Renan , Kahraman Nail , Demir Deniz 
Published: November 2022

Objective To investigate the predictive role of systemic immune-inflammation index (SII) on postoperative poor outcome in patients undergoing carotid endarterectomy (CEA). Methods A total of 347 patients undergoing elective isolated CEA between March 2010 and April 2022 were included in this multicenter retrospective observational cohort and risk-prediction study and were divided into two groups as poor outcome group ( n = 23) and favorable outcome group ( n = 324). Poor outcome was defined as the presence of at least one of the complications within 30 days of surgery including stroke, myocardial infarction, and death. The patients' baseline clinical characteristics, comorbidities, and hematological indices were derived from the complete blood count (CBC) analysis, and perioperative data, outcomes, and complications were screened, recorded, and then compared between the groups. Multivariate logistic regression and receiver-operating characteristic (ROC) curve analyses were conducted following univariate analyses to detect the independent predictors of poor outcome as well as the cutoff values with sensitivity and specificity rates. Results A total of 23 patients out of 347 (6.6%) manifested poor outcome; and stroke, myocardial infarction, and death occurred in 13, 3, and 7 cases, respectively. There were no significant differences between the groups in terms of basic clinical characteristics, comorbidities, and perioperative data, except for lengths of intensive care unit and hospital stays. Although the median values of PLT, PLR, NLR, and SII of the poor outcome group were found to be significantly higher than the favorable outcome group in univariate analysis, only SII was detected to be a significant and independent predictor of poor outcome in multivariate logistic regression analysis (OR = 1.0008; 95% CI: 1.0004–1.0012; p = 0.002). ROC curve analysis revealed that SII of 1356 × 103/mm3 constituted the cutoff value for predicting poor outcome with 78.3% sensitivity and 64.5% specificity (AUC = 0.746; 95% CI: 0.64–0.851). Conclusions Our study revealed for the first time in the literature that SII significantly predicted poor outcome after CEA.
Carbon nanoparticles induce DNA repair and PARP inhibitor resistance associated with nanozyme activity in cancer cells
Authors: Fan Haiyan , Sun Qinglei , Dukenbayev Kanat , Benassi Enrico , Manarbek Limara , Nurkesh Ayan A. , Khamijan Medina , Mu Chenglin , Li Guoliang , Razbekova Madina , Chen Zhenbang , Amin Amr , Xie Yingqiu 
Published: November 2022

Abstract
Background
Quantum nanodots especially carbon nanoparticles (CNPs) have been widely studied in biomedicine in imaging, and drug delivery, but anti-cancer mechanisms remain elusive.

Methods
Here, we investigated a type of cell death induced by food (beet, soybean) derived CNPs in cancer cells and tested whether CNPs induced DNA damage and resistant to anti-cancer agent PARP inhibitor (PARPi) could be overcome by quantum calculations, TEM, AFM, FT-IR, soft agar assay, and cytotoxicity assay.

Results
At high doses, CNPs derived from beet lead to a pop-like apoptosis (Carbopoptosis) in cancer cells. Quantum mechanical calculations confirmed CNPs binding with phosphate groups as well as DNA bases. At low doses, CNPs develop PARPi drug resistance through interactions between CNPs and PARPi. A synergistic drug effect was achieved with the combination of phosphatase inhibitor (PPi), PARPi, and CNPs. This is corroborated by the fact that sulfur modulated CNPs which exhibit super high phosphatase nanozyme activity abrogated the CNPs induced colony formation in anchorage-independent cancer cell growth.

Conclusion
Thus, our data suggest the CNPs intrinsic nanozyme activity of phosphatase may crosstalk with drug resistance, which can be reversed upon modulations.
Evidence for a chemical arms race between cuckoo wasps of the genus Hedychrum and their distantly related host apoid wasps
Authors: Castillo Ruth , Wurdack Mareike , Pauli Thomas , Keller Alexander , Feldhaar Heike , Polidori Carlo , Niehuis Oliver , Schmitt Thomas 
Published: November 2022

Abstract
Background
Brood parasites can exert strong selection pressure on their hosts. Many brood parasites escape their detection by mimicking sensory cues of their hosts. However, there is little evidence whether or not the hosts are able to escape the parasites’ mimicry by changing these cues. We addressed this question by analyzing cuticular hydrocarbon (CHC) profiles of Cerceris and Philanthus wasps and their brood parasites, cuckoo wasps mimicking the CHC profiles of their hosts. Some of these hosts use hydrocarbons to preserve their prey against fungal infestation and thus, they cannot significantly change their CHC composition in response to chemical mimicry by Hedychrum brood parasites.

Results
We found that the CHC overlap between brood parasites and their hosts was lower in case of host wasps not preserving their prey than in case of prey-preserving host wasps, whose CHC evolution is constrained. Furthermore, the CHC profiles in non-preserving host wasps is more strongly diversified in females than in males, thus in the sex that is chemically mimicked by brood parasites.

Conclusion
Our results provide evidence for a chemical arms race between those hosts that are liberated from stabilizing selection on their chemical template and their parasites.
Dyadic relationship, carer role, and resources: a theory-driven thematic analysis of interviews with informal carers focusing on the stability of home-based care arrangements for people living with dementia
Authors: Köhler Kerstin , Dreyer Jan , Hochgraeber Iris , Pinkert Christiane , von Kutzleben Milena , Holle Bernhard , Roes Martina 
Published: November 2022

Abstract
Background
Most people with dementia live at home and are supported by informal carers. During the care trajectory, the creation of a stable care situation is a guiding principle of informal carers, who often manage complex care arrangements. A recently developed theory – ‘Stability of home-based care arrangements for people living with dementia' (SoCA-Dem) – conceptualises how such care arrangements develop over time, and it highlights the relevance of the dyadic relationship, carer role, and resources with regard to the continuation of home-based care throughout the course of dementia. To further explore these three concepts, and to provide feedback for a further refinement of SoCA-Dem theory, this study aims to gain a deeper understanding of (1) how informal carers perceive their dyadic relationship, their carer role, and the resources of the care arrangement, and (2) how these concepts are interrelated.

Methods
This study was a secondary data analysis of n = 11 problem-centred interviews. Data were interpreted by a thematic qualitative text analysis.

Results
The findings distinguished subthemes within the concepts and uncovered their interrelations. The kinship relation, living situation and character of the dyadic relationship shaped informal carers’ self-conception of the carer role. This influenced the integration of resources into the care arrangement. Conversely, the quantity and quality of informal and formal support resulted in a feeling of relief or overload in the carer role, that shaped the informal carers’ way of living their dyadic relationship. The respective forming of the concepts had a significant impact with regard to the perceived stability or instability of the care situation in the examined care arrangements.

Conclusions
This study provided valuable evidence for future research alignment and targeted refinement of the SoCA-Dem theory. Scholars should further explore the specifics of spousal versus parent–child-dyads to better understand the dyads' diverse strategies in the creation of stable home-based care arrangements. Furthermore, future research should focus on the complex dynamics of dyads, family networks, and service providers, and all actors’ perspectives should be integrated in SoCA-Dem theory. Based on this growing knowledge base, innovative care interventions and structures should be developed to support people with dementia and their informal carers in better living and caring in the place of their choice.