bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excretion of Ergometrine Maleate Injection into Breast Milk and Safety Evaluation of Breastfeeding
Authors: Chen miaomiao , Song Tianmi , Xu Jiacheng , Chao Bingdi , Wang Jie , Luo Xin , Qi Hongbo 
Published: September 2022

Abstract
Background
Ergometrine maleate injection as a first-line drug to prevent postpartum hemorrhage. To investigate the safety of ergometrine maleate injection and breastfeeding.
Methods
Pregnant women were recruited into this study according to the inclusion and exclusion criteria and their peripheral blood and breast milk were collected for the first time (some pregnant women have no milk at this time). After the delivery of the fetus, some parturients were further excluded according to the exclusion criteria. The recruited women were randomly divided into the control group and the treat group. The peripheral blood was collected in the control group at 2h and 12h after delivery, respectively, and the peripheral blood and breast milk were collected in the treat group at 2h, 4h, 6h and 12h after delivery, respectively. The concentrations of ergometrine maleate in maternal plasma and breast milk at different periods were detected by ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLC-MS), and prolactin levels at different time gradients after delivery were detected with chemiluminescence.
Results
Sixty-four women were finally recruited, with 32 in the treat group and 32 in the control group. The final concentration of ergometrine maleate injection reached the peak at 2h after administration and basically decreased to the pre-administration level at 12h after administration in both serum and breast milk. The RID was 4.5762% (2.5146%, 7.8638%) and 0.1842% (0.0000%, 1.1838%) at 6h and 12h after administration, respectively. Ergometrine maleate injection does not affect the PRL concentrations in peripheral blood at 2h and 12h.
Conclusion
The results suggest that breastfeeding at 12h after ergometrine maleate injection is relatively safe. In this study, ergometrine maleate injection was not found to inhibit the concentration of PRL in the peripheral blood, and no serious adverse reactions were found.
Real-time parameter updating for nonlinear digital twins using inverse mapping models and transient-based features
Authors: Kessels Bas Mats , Fey Rob H.B. , de Wouw Nathan van 
Published: September 2022

Abstract
In the context of digital twins, it is essential that a model gives an accurate description of the (controlled) dynamic behavior of a physical system during the system’s entire operational life. Therefore, model updating techniques are required that enable real-time updating of physically interpretable parameter values and are applicable to a wide range of (nonlinear) dynamical systems. As traditional, iterative, parameter updating methods may be computationally too expensive for real-time updating, the Inverse Mapping Parameter Updating (IMPU) method is proposed as an alternative. For this method, first, an Artificial Neural Network (ANN) is trained offline using novel features of simulated transient response data. Then, in the online phase, this ANN maps, with little computational cost, a set of measured output response features to parameter estimates enabling real-time model updating. In this paper, various types of transient response features are introduced to update parameter values of nonlinear dynamical systems with increased computational efficiency and accuracy. To analyze the efficacy of these features, the IMPU method is applied to a (simulated) nonlinear multibody system. It is shown that a smart selection of features, based on, e.g., the frequency content of the transient response, can improve the accuracy of the estimated parameter values, leading to more accurate updated models. Furthermore, the generalization capabilities of the ANNs are analyzed for these feature types, by varying the number of training samples and assessing the effect of incomplete training data. It is shown that the IMPU method can predict parameter values that are not part of the training data with acceptable accuracy as well.
Effect of cutting tool geometry on hole quality in orbital drilling. Application to titanium alloy Ti-6Al-4V
Authors: REY Pierre-andre , Senatore Johanna , Landon Yann 
Published: September 2022

Abstract
The orbital drilling process is a very complex machining operation. Due to the helical path of the tool in the material and the sometimes very complex tool geometry, the geometry of the chip is very variable along the cutting edge and during a revolution of the tool. tool. This complexity explains why the cutting forces are very variable during drilling and they are very difficult to model and estimate for different tool geometries. The aim of this study is therefore to develop a cutting force model taking into account the geometry of the tool and the cutting conditions. The final objective is to control the final quality of the machined borehole. First, the geometry of the chip is modeled from the cutting parameters defining the trajectory and from the macro-geometry of the tool. Cutting force models, based on the instantaneous chip thickness and applied to the drilling, are then implemented. An experimental study validates the modeling by cutting force measurements carried out during orbital drilling tests. From this modeling, it is now possible to study the influence of the geometry of the cutting tool on the forces in order to control the loading on the tool and therefore the final quality of the drilling.
Proteomic analysis of the effect of hemin in breast cancer
Authors: Coló G. P. , Schweitzer K. , Oresti G.M. , Alonso E.G. , Chávez L. Fernández , Mascaró M. , Giorgi G. , Curino A.C. , Facchinetti M.M. 
Published: September 2022

Abstract

Heme, an iron-containing prosthetic group found in many proteins, carries out diverse biological functions such as electron transfer, oxygen storage and enzymatic reactions. Hemin, the oxidised form of heme, is used to treat porphyria and also to activate heme-oxygenase (HO) which catalyses the rate-limiting step in heme degradation. Our group has previously demonstrated that hemin displays antitumor activity in breast cancer (BC). The aim of this work has been to study the effect of hemin on protein expression modifications in a BC cell line to gain insight into the molecular mechanisms of hemin antitumor activity. For this purpose, we carried out proteome analysis by Mass Spectrometry (MS) which showed that 1309 proteins were significantly increased in hemin-treated cells, including HO-1 and the proteases that regulate HO-1 function, and 921 proteins were significantly decreased. Furthermore, the MS-data analysis showed that hemin regulates the expression of heme- and iron- related proteins, adhesion and cytoskeletal proteins, cancer signal transduction proteins and enzymes involved in lipid metabolism. By biochemical and cellular studies, we further corroborated the most relevantin-silicoresults. Altogether, these results show the multiple physiological effects that hemin treatment displays in BC and demonstrate its potential as anticancer agent.
Sustainable Microalgae Growth in Jamaican Industrial Wastewater for Biofuel Production
Authors: Johnson Jervian , English Renee , Johnson Jervian 
Published: September 2022

Abstract
Purpose
The study determined the feasibility of combining phytoremediation of industrial wastewater and biofuel production from microalgae cultivation.
Methods
Seed cultures of algal species Botryococcus braunii and Chlorella sp., cultivated in nitrogen-phosphorus-potassium (NPK) fertilizer medium, were used to inoculate wastewater samples collected from an abattoir and a creamery. The resulting change in nutrient concentration in the wastewater samples was determined using the American Public Health Association (APHA) standard methods. Algal growth was method measured by gravimetric analysis. Bio-oil extraction was conducted using APHA standard methods, while biodiesel was analysed using gas chromatography – mass spectrometry.
Results
When the microalgae species Botryococcus braunii and Chlorella sp. were cultured in dairy and chicken-processing plant wastewaters, their growth rates increased as Chemical Oxygen Demand (COD), Biological Oxygen Demand (BOD) and nutrients (nitrates and phosphates) depleted, in accordance with the Droop model. The oil content of the B. braunii species was 26.25% (w/w) and 33.60% (w/w) in dry biomass weight from the abattoir and creamery respectively; while the oil content of Chlorella sp. species was 47.27% (w/w) and 26.42% (w/w) in dry biomass weight from the abattoir and creamery respectively. The analysed lipid extracts indicated the presence of fatty acid methyl esters (FAMEs), hexadecanoic acid methyl ester and octadecadienoic acid methyl ester, which were found to be suitable for use in biodiesel production.
Conclusion
It is technically feasible to treat industrial wastewaters with microalgal strains, Botryococcus braunii and Chlorella sp., which in turn accumulates oil that can be extracted and converted to bio-diesel.
Which interventions for alcohol use should be included in a universal healthcare benefit package? An umbrella review of targeted interventions to address harmful drinking and dependence.
Authors: Botwright Siobhan , Sutawong Jiratorn , Kingkaew Pritaporn , Anothaisintawee Thunyarat , Dabak Saudamini , Suwanpanich Chotika , Promchit Nattiwat , Kampang Roongnapa , Isaranuwatchai Wanrudee 
Published: September 2022

Abstract

Background
This study aimed to identify targeted interventions for the prevention and treatment of harmful alcohol use. Umbrella review methodology was used to summarise the effectiveness across a broad range of interventions, in order to identify which interventions should be considered for inclusion within universal health coverage schemes in low- and middle-income countries.
Methods and findings
We included systematic reviews with meta-analysis of randomised controlled trials (RCTs) on targeted interventions addressing alcohol use in harmful drinkers or individuals with alcohol use disorder. We only included outcomes related to alcohol consumption, heavy drinking, binge drinking, abstinence, or alcohol-attributable accident, injury, morbidity or mortality. PubMed, Embase, PsychINFO, Cochrane Database of Systematic Reviews, and the International HTA Database were searched from inception to 3 September 2021. Risk of bias of reviews was assessed using the AMSTAR2 tool. After reviewing the abstracts of 9,167 articles, results were summarised narratively and certainty in the body of evidence for each intervention was assessed using GRADE. In total, 89 studies met the inclusion criteria, of which the majority reported outcomes for brief intervention (30 studies) or pharmacological interventions (30 studies). Overall, methodological quality of included studies was low.
Conclusions
For harmful drinking, brief interventions, cognitive behavioural therapy, and motivational interviewing showed a small effect, whereas mentoring in adolescents and children may have a significant long-term effect. For alcohol use disorder, social network approaches and acamprosate showed evidence of a significant and durable effect. More evidence is required on the effectiveness of gamma-hydroxybutyric acid (GHB), nalmefene, and quetiapine, as well as optimal combinations of pharmacological and psychosocial interventions. As an umbrella review, we were unable to identify the extent to which variation between studies stemmed from differences in intervention delivery or variation between country contexts. Further research is required on applicability of findings across settings and best practice for implementation.
Funded by the Thai Health Promotion Foundation, grant number 61-00-1812.
Pharmacokinetics of Ropivacaine in elderly Patients with combination of paravertebral nerve and lumbosacral plexus blocks for Hip Surgeries
Authors: Chu Qinjun , Wang Pengfei , Xie Weiwei , Sun Liwei , Zhang Dongqing , Li Jiangfeng , Zhang Chenxi , Jin Xiaogao 
Published: September 2022

Abstract
Objective:This study is to describe the pharmacokinetics of ropivacaine in elderly patients with multiple nerve blocks for hip surgeries.
Methods: The patients aged over 65 years with ASA II-III, BMI<35kg/m2, weight>50kg, Albumin>25g/L, and creatinine clearance>30ml/min, undergoing unilateral hip surgery were enrolled in this study. All the patients received unilateral hip surgery under combination of paravertebral nerve (T12, L1) and lumbosacral plexus block (CPLSB) with total dose of 245 mg ropivacaine. The total and free plasma concentrations of ropivacaine were measured from arterial sample using ultra-performance liquid chromatography (UPLC).
Results: A total of 40 elderly patients were investigated and analyzed in this study. No signs of LAST were found during the study. The Tmax, Cmax, and t1/2 of free ropivacaine were 23（20.25-26.75）min, 0.1701（0.1201-0.2499）microgram/ml, and 416.2（306.9-618.9）min, respectively. The concentration of free ropivacaine fluctuated significantly within 80 min and presented with multiple peaks on the concentration-time curve. Multiple linear regression analysis found that there were no relationships between Cmax of free ropivacaine and the factors including gender, age, height, weight, dose, incomplete blocks, duration of injection, blood loss, red cell transfusion, infusion fluids, surgery types, and operation time.
Conclusion:The serum free concentration of 245 mg ropivacaine in elderly patients with multiple nerve blocks for hip surgery was below the assumed systemic toxic threshold of 0.46microgram/ml. However, the serum ropivacaine free concentration fluctuated significantly and was hard to predict for the first 80 min after local ropivacaine injection.
Evaluation of the implementation of hospital hygiene components in 30 health-care facilities in the Autonomous District of Abidjan (Cote d'Ivoire) with the WHO Infection Prevention and Control Assessment Framework (IPCAF)
Authors: Cissé Doumbia Mariamou , Essis Esme Marie Laure , Koné Atioumounan Blaise , N’gbesso Jean Paul N’gbesso , Mbengue Valérie Gbonon , Cissé Raïssa Adja Mayaka , Gagne Doh Eugénie , Dagnan N’cho Simplice , Kouadio Luc Philippe , Samba Mamadou 
Published: September 2022

Abstract
Introduction: As part of the implementation of its mission "to integrate hygiene activities into health-care", the general directorate of health conducted in 2018 with its technical structures, an evaluation of the implementation of Infection Prevention and Control (IPC) using the WHO IPCAF tool in 30 health-care facilities in the autonomous district of Abidjan.
Material and methods: This were a cross-sectional survey with a conceptualized component considering the issue of injection safety and sanitary waste management, which was conducted in the named health-care facilities from March 20 to 28, 2018. The scores of the essential components of the IPC made it possible to assess the IPC level of each health-care facility evaluated and the overall IPCAF score of all facilities.
Results: The overall median IPCAF score of the health-care facilities was 242.5 / 800 and corresponded to an inadequate level overall. No facility reached the "advanced" level of performance, 5 facilities (17%) reached the "intermediate" level, 10 (33%) fell into the "basic" level, and 15 (50%) were at the "inadequate" level. Baseline institutions had much higher scores than first contact institutions.
Conclusion: IPC component activities were inadequate and fragmented in the under-resourced health facilities at the time of the assessment. It would be appropriate to provide adequate resources and develop expertise in IPC through strong political will and leadership. This will contribute to the achievement of Universal Health Insurance objectives with safe health services for patients.
Women’s Empowerment and Nutritional Status of Children in The Gambia: Further Analysis of the 2019–2020 Gambia Demographic and Health Survey
Authors: Sey-Sawo Jainaba , Sarr Francis , Bah Haddy Tunkara , Senghore Thomas 
Published: September 2022

Abstract

Background: Empowering women and the promotion of children’s health are key components of the Sustainable Development Goals targeted for achievement by 2030. The survival of young children, which depends on their nutrition, is influenced by an interaction of factors at the household level. This study aims to investigate the association between women’s empowerment and undernutrition among children under age 5 using The Gambia Demographic Health Survey (GDHS) 2019–20.
Children’s undernutrition was measured with two indicators: stunting and underweight. The women’s empowerment indicators were educational status, employment, decision making, age at first sex and birth, and acceptance of wife beating. StataSE software Version 17 was used for data analysis. Analyses were cluster-adjusted, sample-weighted, with confounding/moderating variables. Descriptive statistics and cross-tabulations were computed for all variables. Bivariate and multivariate analysis of the outcomes and women’s empowerment were conducted.
The prevalence of stunting and underweight among the children under age 5 was 17% and 12%, respectively. The results of the multiple logistic regression show that women with no education had 51% (OR = 1.51; 95% CI = 1.11–2.07; p = 0.009), and 52% (OR = 1.52; 95% CI = 1.06–2.14; p = 0.022) greater odds of having children under age 5 who were stunted or underweight compared to those women with primary and higher level of education, respectively. Mothers with a body mass index classified as thin were associated with an increased odds of having stunted (OR = 1.44; 95% CI 1.01–2.05; p = 0.033) and underweight (OR = 1.69; 95% CI = 1.58–3.52; P<0.001) children. In addition, women who reported accepting wife beating had 69% (OR = 1.69; 95% CI 1.22–2.35; p = 0.002) and 66% (OR = 1.66; 95% CI 1.15–2.40; p = 0.006) greater odds of having stunted and underweight children respectively, compared to those who did not accept wife beating. Similarly, women from households with a wealth index classified as poor had 69% (OR = 1.69; 95% CI 1.03–2.80; p = 0.038) and 83% % (OR = 1.83; 95% CI 1.18–2.83; p = 0.007) greater odds of having underweight and stunting children compared to those from households with middle or rich wealth index.
Observation of large spontaneous emission rate enhancement of quantum dots in a broken-symmetry slow-light waveguide
Authors: Siampour Hamidreza , O'Rourke Christopher , Brash Alistair J , Makhonin Maxim N , Dost René , Hallett Dominic J , Clarke Edmund , Patil Pallavi Kisan , Skolnick Maurice S , fox mark 
Published: September 2022

Abstract
Quantum states of light and matter can be manipulated on the nanoscale to provide a technological resource for aiding the implementation of scalable photonic quantum technologies [1-3]. Experimental progress relies on the quality and efficiency of the coupling between photons and internal states of quantum emitters [4-6]. Here we demonstrate a nanophotonic waveguide platform with embedded quantum dots (QDs) that enables both Purcell-enhanced emission and strong chiral coupling. The design uses slow-light effects in a glide-plane photonic crystal waveguide with QD tuning to match the emission frequency to the slow-light region. Simulations were used to map the chirality and Purcell enhancement depending on the position of a dipole emitter relative to the air holes. The highest Purcell factors and chirality occur in separate regions, but there is still a significant area where high values of both can be obtained. Based on this, we first demonstrate a record large radiative decay rate of 17 ns^-1 (60 ps lifetime) corresponding to a 20 fold Purcell enhancement. This was achieved by electric-field tuning of the QD to the slow-light region and quasi-resonant phonon-sideband excitation. We then demonstrate a 5 fold Purcell enhancement for a dot with high degree of chiral coupling to waveguide modes, substantially surpassing all previous measurements. Together these demonstrate the excellent prospects for using QDs in scalable implementations of on-chip spin-photonics relying on chiral quantum optics.
Parametric identification of fractional order system using Bayesian method
Authors: Jin Zhaopeng , Zhang Jie , Zhao Yanzhi , Tang Yinggan , Shan Yu , Sun Yue 
Published: September 2022

Abstract
In this paper, the estimation issue for fractional order system with unknown parameter and order is addressed. The Bayesian method is used for system identification. First, the framework of parameter identification algorithm is built and the conjugate prior is constructed. Then, an improved descent method is used to update the posterior distribution based on the idea of maximum likelihood function. The proposed method solves the problem of overall identification of order and parameters, and can also estimate the noise in the system. Finally, numerical experiments comparing with the optimization algorithm are completed. Experiments on prediction performance, convergence ability and time complexity verify the effectiveness and speed of the proposed algorithm.
Multi-omics integration of DNA polymerase epsilon protein family reveals clinical outcomes and functional signatures in hepatocellular carcinoma
Authors: Zhang XuSheng , Ma Yongxin , Liu Kejun , Liu Yimin , Zhou Hongcai , Wei Peng , Yu Xuehai , Chen Bendong 
Published: September 2022

Abstract
BACKGROUND
Numerous genetic sequencing projects have demonstrated that alterations in Polε (DNA polymerase epsilon ) due to various causes are associated with the development of multiple human cancers. However, the biological functions of its four core genes, POLE1/2/3/4/, in the occurrence, progression, and prognosis of hepatocellular carcinoma(HCC) remain poorly understood to date.
METHODS
Multi-omics, multi-level deep mining of HCC data from TCGA and other publicly available databases by using online analysis tools from GEPIA2, TIMER2.0, DAVID, Kaplan-Meier plotter, cBioPortal and MethSurv databases, as well as the R package to assess Polε family members in HCC for their potential biological functions.
RESULTS
We found that the four target genes were significantly upregulated in HCC (P < 0.001), their high expression was associated with a lower survival rate (P < 0.05), and both diagnostic ROC curves and disease-specific survival time-dependent ROC curves suggested that POLE2/3 showed better disease predictive efficacy, and the four genes were significantly associated with immune infiltration, and drug sensitivity analysis suggested that the high expression groups showed higher drug sensitivity in some chemotherapeutic drugs(P < 0.001).
CONCLUSIONS
The POLE1/2/3 are potential prognostic predictive molecules for HCC and correlate with immune infiltration, and high expression of POLE may serve as a potential predictor of the effect of targeted therapies. POLE2/3 may be the potential diagnostic biomarkers for HCC, and the expression level of POLE3 may be a biological predictor of HCC chemotherapy sensitivity.