bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medication-related osteonecrosis of the jaw – a scoping review
Authors: Gogtay Nithya Jaideep , Soni Dhruve , Pandit Sukant 
Published: April 2022

Summary
Medication-related osteonecrosis of the jaw [MRONJ] is a rare, often intractable, and debilitating condition that is associated with multiple therapies. The condition can be asymptomatic or become chronic adversely affecting the patient's quality of life. Case definitions of MRONJ have been given by the American Association of Oral and Maxillofacial Surgeons [AAOMS] and the American Society for Bone and Mineral Research [ASBMR] and history of use [or current] of anti-resorptive agents and anti-angiogenic agents form a key component of the definition. The exact pathophysiology of this condition remains unclear though the jaw and especially the mandible is uniquely susceptible. Beyond drug treatment, there are several risk factors that have been identified for MRONJ that include among others local, demographic, systemic and genetic factors. Management of the condition is multi-disciplinary and includes both surgical and conservative approaches depending upon the stage of the disease. Several experimental treatments have been tried some of which include photo biomodulation, hyperbaric oxygen therapy and use of autologous platelet concentrates. Mitigation of MRONJ begins with risk assessment and counselling of the patients prior to initiating treatments known to be associated with it and regular ongoing monitoring. As more and more biologics enter the market, MRONJ has come to be associated not just with bisphosphonates or denosumab but also with drugs like tyrosine kinase inhibitors and calcineurin inhibitors and physicians need to bear this in mind.
The SIEA SHRIMP Flap: An Ultrathin Axial Pattern Free Flap Useable in Obese Patients
Authors: Felder John M. , Willborg Brooke E. , Zhu William Y. 
Published: April 2022

Summary:
The reconstruction of distal extremity wounds poses a unique surgical challenge. In free tissue transfer, a thin, pliable skin flap is the ideal. Obese patients have a paucity of thin skin donor sites. Herein we report the discovery of a free SHRIMP flap (Superthin Harvest of a Reliable Islanded Medial Pannus flap) based on the SIEA vessels, harvested from a thick abdominal pannus at the time of cosmetic abdominoplasty. A 61-year-old woman with a chronic wound of the right Achilles tendon was evaluated for reconstruction after failing conservative measures. At the time of consultation, the patient expressed interest in abdominoplasty. Therefore, a skin flap from the abdomen or rectus abdominis muscle flap in the context of an abdominoplasty was offered. Despite obesity affecting the pannus, the superficial inferior epigastric vessels were found to course superficially beneath the dermis at time of abdominoplasty. This allowed straightforward harvest of a superthin flap of skin and minimal subcutaneous fat, which contoured to the ankle with an aesthetically pleasing outcome. The patient was satisfied with the results of her abdominoplasty and coverage of her chronic wound. The SHRIMP flap provides a straightforward, axial pattern, superthin free skin flap based on the superficial inferior epigastric vessels, and represents a useful option in obese patients. The flap can be combined with abdominoplasty for an aesthetic donor site.
A Novel Technique for Nasal Alar Reconstruction
Authors: Nadjmi Nasser , Vaes Lukas , Van de Casteele Elke 
Published: April 2022

Summary:
Reconstruction of full-thickness alar defects is delicate. Small asymmetries are visible because of the central position of the nose. Different alar reconstruction techniques such as the nasolabial, bilobed, and composite grafts provide an excellent option to reconstruct alar skin and texture. However, these donor tissues will never perfectly match alar tissue in terms of color and contour. This report presents a case of a 56-year-old woman with alar asymmetry due to soft tissue loss of the right alar rim, para-nasal, and nasolabial groove as consequence of a severe trauma in the past. Scarring tissue, retractions, and suboptimal tissue quality on the right side of the face complicated a standard procedure. In this case, a novel reconstruction technique was planned for alar reconstruction. In a two-staged procedure, a well-perfused alar base flap from the contralateral side was raised to recreate the basal portion of the right lateral alar rim. Concomitantly a lip lifting procedure was performed to correct the inadequate incisal show. As result, perfectly matching skin color, texture, and correction toward alar and facial symmetry were realized. Satisfactory aesthetic outcome for the patient was achieved. The final result was evaluated 12 months postoperatively by the use of stereophotogrammetry technology.
Comparative efficacy and safety of traditional Chinese patent medicine for cognitive dysfunction in diabetic cognitive dysfunction
Authors: Wang Kai , Jiang Zhenyuan , Yu Xiaowen , Shao Yuze , Liu Hailiang , Wu Susu , Kong Linghui , Wang Zhonglin 
Published: April 2022

Abstract

Background:
More and more studies have shown that cognitive dysfunction is one of the main complications of diabetes. The disorder of glucose and lipid metabolism seriously damages brain function and accelerates the conversion to dementia. At present, there are no drugs that can directly treat diabetic cognitive dysfunction. All drugs for the treatment of this disease achieve the purpose of treatment through strict control of blood sugar levels. This method has great limitations. Traditional Chinese patent medicines (TCPMs) work through multiple targets and multiple pathways, which can not only effectively correct the state of glucose and lipid metabolism disorders, but also significantly improve cognitive ability, but there is a lack of systematic evaluation of their effectiveness and safety. We use the method of network meta-analysis to systematically and comprehensively compare the effectiveness and safety of different Chinese patent medicines.

Methods:
We will comprehensively search the following databases, including Web of Science, PubMed, The Cochrane Library, EMBASE, China National Knowledge Infrastructure, Chinese Scientific Journals Database, Wanfang database and China BioMedical Literature. We will include all randomized controlled trials that meet the inclusion criteria, starting from the establishment of the database until September 2021. Two researchers will independently screen the literature based on inclusion criteria. While extracting data, we also assess the risk of bias in the included studies. All the data and evidence obtained will be evaluated by the method of Bayesian network meta-analysis.

Results:
This study will evaluate the effectiveness and safety of various TCPMs for diabetic cognitive dysfunction.

Conclusion:
The results of this study will provide valuable references for the clinical application of TCPMs, and assist clinicians in formulating more reasonable diagnosis and treatment strategies.

Ethics and dissemination:
This study does not require ethical approval.

International Platform of Registered Systematic Review and Meta-analysis Protocols registration number:
INPLASY202190008.
The efficacy and safety of massage adjuvant therapy in the treatment of diabetic peripheral neuropathy
Authors: Ren Longsheng , Guo Ruiying , Fu Guojing , Zhang Jie , Wang Qiang 
Published: April 2022

Abstract

Background
The incidence of diabetic peripheral neuropathy (DPN) is increasing year by year. If patients cannot receive timely and effective treatment, DPN may lead to diabetic foot ulcers or even amputation. This risk factor has been widely concerned around the world. Massage, as a non-invasive physical therapy method, is gradually being applied in the adjuvant treatment of DPN. However, there is no systematic review of the adjuvant treatment of DPN by massage. Our study will explore the effectiveness and safety of massage applied in DPN.

Methods
Eight electronic databases (PubMed, Cochrane, Web of Science, Sinomed, Embase, China National Knowledge Infrastructure, WanFang Data, Chongqing VIP Information) will be searched by our computer on February 9, 2022. A randomized controlled trial (RCT) of adjuvant massage therapy for DPN was screened. Primary outcome measures: efficiency, nerve conduction velocity. Secondary outcome measures: pain, blood glucose, and incidence of adverse reactions. The quality of the study was evaluated by two researchers using the RCT bias risk assessment tool in the Cochrane review manual Handbook5.4, and meta-analysis was performed by RevMan5.4 software.

Results
RCTs will be used to evaluate the clinical efficacy of massage adjuvant therapy in DPN.

Conclusion
This study will provide evidence-based evidence for the safety and effectiveness of massage adjuvant therapy in DPN.

Protocol registration number:
INPLASY202220025.
Athletic Osteitis Pubis Detected on 18F-FDG PET/CT
Authors: Broos Wouter A. M. , van der Zant Friso M. , Knol Remco J. J. 
Published: April 2022

Abstract
A 37-year-old male personal trainer presented with debilitating groin pains, fever, and night sweats. Enlarged inguinal lymph nodes were noticed during physical examination, and blood tests showed elevated erythrocyte sedimentation rate and C-reactive protein. 18F-FDG PET/CT excluded lymphoma and other malignancy but showed intense FDG uptake at the pubic symphysis and cortical erosions of the pubic bones on CT. The patient was diagnosed with osteitis pubis, an inflammatory condition of the pubic symphysis commonly seen in athletes. Treatment with anti-inflammatory drugs was initiated. Within several weeks, pain decreased, and inflammatory markers normalized.
Pelagibius marinus sp. nov., a novel bacterium isolated from marine sediment, and emended description of the genus Pelagibius
Authors: Yang Chen , Zhu Suting , Sun Chaoling , Ding Lijian , Jung Dawoon , He Shan , Wang Ning , Zhang Weiyan 
Published: April 2022

A Gram-stain-negative, rod-shaped, motile and aerobic marine bacterium, designated strain NBU2595T, was isolated from marine sediment sampled on Meishan Island, located in the East China Sea. Strain NBU2595T grew at 10–40 °C (optimum, 37 °C), at NaCl concentration of 0–10.0 % (w/v; optimum, 0.5 %) and at pH 6.0–8.0 (optimum, pH 7.0). Catalase and oxidase activities and H2S production were positive. Methyl red reaction and hydrolysis of casein, starch and Tweens 20, 40, 60 and 80 were negative. The major cellular fatty acids were summed feature 8 (C18 : 1
ω7c and/or C18 : 1
ω6c), C18 : 1 2-OH and C18 : 0 3-OH. The sole respiratory quinone was ubiquinone 10. The major polar lipids were phosphatidylglycerol, phosphatidylcholine, phosphatidylethanolamine and phosphatidylmonomethylethanolamine. Comparative analysis of 16S rRNA gene sequences showed highest similarity to

Pelagibius litoralis

CL-UU02T (97.9%), and low similarities (<92.9 %) to other species. Phylogenetic analyses indicated that strain NBU2595T clustered with the genus

Pelagibius

and was closely related to

P. litoralis

CL-UU02T. The average nucleotide identity and digital DNA–DNA hybridization values between strain NBU2595T and the related species of the genus

Pelagibius

were well below the thresholds for prokaryotic species delineation. The DNA G+C content was 66.5 mol%. Based on its phenotypic, chemotaxonomic and genotypic data, strain NBU2595T should be placed in the genus

Pelagibius

as representing a novel species, for which the name Pelagibius marinus sp. nov. is proposed. The type strain is NBU2595T (=MCCC 1K04773T=KCTC 82223T).
Molecular identification and antifungal susceptibility of clinically relevant and cryptic species of Aspergillus sections Flavi and Nigri
Authors: Nargesi Sanaz , Jafarzadeh Jalal , Najafzadeh Mohammad Javad , Nouripour-Sisakht Sadegh , Haghani Iman , Abastabar Mahdi , Ilkit Macit , Hedayati Mohammad Taghi 
Published: April 2022

Introduction.
Aspergillus sections Flavi and Nigri comprise clinically relevant and cryptic species that differ significantly in drug susceptibility, meaning that effective treatment depends on correct species identification.

Hypothesis/Gap Statement. There are no comprehensive data for molecular identification and antifungal susceptibility testing (AFST) of clinically relevant and cryptic species of Aspergillus sections Flavi and Nigri as the main agents of invasive and non-invasive aspergillosis in Iran.
We aimed to perform molecular identification and AFST of 213 clinical Aspergillus isolates belonging to sections Flavi and Nigri.
Molecular identification of isolates was performed using sequencing of the β-tubulin gene and in vitro AFST was conducted according to the Clinical and Laboratory Standards Institute (CLSI) M38-A3 guidelines.

Results. The most common isolates in sections Flavi and Nigri were Aspergillus flavus (110/113, 97.3 %) and Aspergillus tubingensis (49/100, 49.0 %), respectively. A total of 62/213 (29.1 %) isolates belonging to cryptic species were identified; among them, A. tubingensis was the most prevalent (49/62, 79.0%). Aspergillus flavus and A. niger isolates that responded to the minimum inhibitory concentrations (MICs) of itraconazole above the epidemiological cutoff values were the most frequently detected: 8/110 (7.3 %) and 3/41 (7.3 %), respectively. In section Flavi, Aspergillus alliaceus responded to amphotericin B at a high MIC (>16 µg mL−1) and in section Nigri, one of the three Aspergillus luchuensis/awamori isolates responded to itraconazole at an MIC >16 µg ml−1. Interestingly, for all Aspergillus welwitschiae isolates, the MIC50 and MIC90 of itraconazole were both 16 µg ml−1.

Conclusion. A considerable presence of A. flavus and A. niger isolates showing non-wild-type responses to azoles in clinical cases of aspergillosis indicates the importance of classifying clinical Aspergillus isolates at the species level and performing antifungal susceptibility testing on the isolates, which would ensure appropriate treatment.
Changes of LipoxinA4 Levels Following Early Hospital Management of Patients with Non-Severe COVID-19: A Pilot Study
Authors: Jamali Farzaneh , Shahrami Bita , Mojtahedzadeh Amirmahdi , Najmeddin Farhad , Arabzadeh Amir Ahmad , Hadadi Azar , Sharifzadeh Mohammad , Mojtahedzadeh Mojtaba 
Published: April 2022

AbstractLipoxinA4 (LXA4) is an anti-inflammatory biomarker participating in the active process of inflammation resolution, which is suggested to be effective on infectious and inflammatory diseases like COVID-19. In this study, we hypothesized that LXA4 levels may increase following COVID-19 treatment and are even more accurate than commonly used inflammatory markers such as erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), and ferritin. To test this hypothesis, a pilot study was conducted with 31 adult hospitalized patients with non-severe COVID-19. LXA4 levels were measured at the baseline and 48-72 hours later. Accordingly, ESR and CRP levels were collected on the first day of hospitalization. Moreover, the maximum serum ferritin levels were collected during the five days. LXA4 levels significantly increased at 48-72 hours compared to the baseline. ESR, CRP, and ferritin levels were positively correlated with the increased LXA4. In contrast, aging was shown to negatively correlate with the increased LXA4 levels. LXA4 may be known as a valuable marker to assess the treatment response among non-elderly patients with non-severe COVID-19. Furthermore, LXA4 could be considered as a potential treatment option under inflammatory conditions. Further studies are necessary to clarify LXA4 role in COVID-19 pathogenesis, as well as the balance between such pro-resolving mediators and inflammatory parameters.
Statistical evaluation of metaproteomics and 16s rRNA amplicon sequencing techniques for the study of the gut microbiota establishment of infants with cystic fibrosis
Authors: Saralegui Claudia , García-Durán Carmen , Romeu Eduardo , Hernáez-Sánchez María Luisa , Maruri Ainhize , Bastón-Paz Natalia , Lamas Adelaida , Vicente Saioa , Pérez-Ruiz Estela , Delgado Isabel , Luna-Paredes Carmen , de Dios Caballero Juan , Zamora Javier , Monteoliva Lucía , Gil Concepción , Campo Rosa del 
Published: April 2022

ABSTRACTThe newborn screening for cystic fibrosis (CF) can identify affected but still asymptomatic infants. The selection of omic technique for gut microbiota study is therefore crucial due to both the small amount of feces available and the low microorganism load. Our aim was to compare the agreement between 16S rRNA amplicon sequencing and metaproteomics by a robust statistical analysis including McNemar (taxa presence) test and Bland–Altman (taxa abundance) data plotting for studying the sequential establishment of the gut microbiota during the first year of life in 8 infants with CF (28 fecal samples). The taxonomic assignation was similar by the two techniques, whereas certain discrepancies were observed in the abundance detection, mostly the underrepresentation of Bifidobacterium and the overestimation of certain Firmicutes and Proteobacteria by amplicon sequencing. During the first months of life, the CF gut microbiota is characterized by poor alpha diversity, a significant enrichment of Ruminococcus gnavus, the expression of certain virulent bacterial traits, and the detection of human inflammation-related proteins. Our study provides an extended comparative analysis with robust statistical support that could optimize the use of both approaches for gut microbiota research. Metaproteomics provides information on composition and functionality, as well as data on host-microbiome interactions. Its strength is the identification and quantification of Actinobacteria and certain classes of Firmicutes. Both techniques detected an aberrant microbiota in infants with CF during their first year of life, dominated by the enrichment of R. gnavus within a human inflammatory environment.
Cortical facilitation of somatosensory inputs using gravity-related tactile information in patients with bilateral vestibular loss
Authors: Fabre Marie , Beullier Laura , Sutter Chloé , Krebritchi Amirezza , Chavet Pascale , Simoneau Martin , Toupet Michel , Blouin Jean , Mouchnino Laurence 
Published: April 2022

AbstractA few years after their bilateral vestibular loss, individuals usually show a motor repertoire that is almost back to normal. This recovery is thought to involve an up-regulation of the visual and proprioceptive information that compensates for the lack of vestibular information. Here, we investigated whether plantar tactile inputs, which provide body information relative to the ground and to the Earth-vertical, contribute to this compensation. More specifically, we tested the hypothesis that somatosensory cortex response to electric stimulation of the plantar sole in standing adults will be greater in patients (n = 10) with bilateral vestibular loss than in an aged-matched healthy group (n = 10). Showing significant greater somatosensory evoked potentials (i.e., P1N1) in patients than in controls, the electroencephalographic recordings supported this hypothesis. Furthermore, we found evidence that increasing the differential pressure between both feet, by adding a 1 kg mass at each pending wrist, enhanced the internal representation of body orientation and motion relative to a gravitational reference frame. The large decreased in alpha/beta power in the right posterior parietal cortex (and not in the left) is in line with this assumption. Finally, our behavioral analyses showed smaller body sway oscillations for patients, likely originated from a tactile-based control strategy. Conversely, healthy subjects showed smaller head oscillations suggesting a vestibular-based control strategy, the head serving as a reference for balance control.HighlightsSomatosensory cortex excitability is greater in patients with bilateral vestibular loss than in aged-matched healthy individualsTo control balance, healthy individuals “locked” the head while vestibular patients “locked” their pelvisFor vestibular patients, increasing loading/unloading mechanism enhances the internal representation of body state in the posterior parietal cortex
Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapies
Authors: Lang Hervé , Béraud Claire , Cabel Luc , Fontugne Jacqueline , Lassalle Myriam , Krucker Clémentine , Dufour Florent , Groeneveld Clarice S. , Dixon Victoria , Meng Xiangyu , Kamoun Aurélie , Chapeaublanc Elodie , De Reynies Aurélien , Gamé Xavier , Rischmann Pascal , Bieche Ivan , Masliah-Planchon Julien , Beaurepere Romane , Allory Yves , Lindner Véronique , Misseri Yolande , Radvanyi François , Lluel Philippe , Bernard-Pierrot Isabelle , Massfelder Thierry 
Published: April 2022

AbstractBackgroundMuscle-invasive bladder cancer (MIBC) and upper urinary tract urothelial carcinoma (UTUC) are molecularly heterogeneous. Despite chemotherapies, immunotherapies or anti-FGFR treatments, these tumors are still of poor outcome. Our objective was to develop a bank of patient-derived xenografts (PDXs) recapitulating molecular heterogeneity of MIBC and UTUC, to facilitate preclinical identification of therapies.MethodsFresh tumors were obtained from patients and subcutaneously engrafted into immune-compromised mice. Patient tumors and matched PDXs were compared regarding histopathology, transcriptomic (microarrays) and genomic profiles (targeted-NGS). Several PDXs were treated with chemotherapy (cisplatin/gemcitabine) or targeted therapies (FGFR and EGFR inhibitors).Results31 PDXs were established from 1 non-MIBC, 25 MIBC, 5 upper urinary tract tumors, including 28 urothelial (UCC) and 3 squamous-cell carcinomas (SCC). Integrated genomic and transcriptomic profiling identified PDXs of 3 different consensus molecular subtypes (Basal/Squamous, Luminal papillary and Luminal unstable), and included FGFR3-mutated PDXs. High histological and genomic concordance was found between matched patient tumor/PDX. Discordance in molecular subtypes, such as a basal/squamous patient tumor giving rise to a luminal papillary PDX, was observed (n=5) at molecular and histological levels. Ten models were treated with cisplatin-based chemotherapy and we did not observe association between subtypes and response. Of the 3 basal/squamous models treated with anti-EGFR therapy, two models were sensitive and one model, of sarcomatoid variant, was resistant. Treatment of 3 FGFR3-mutant PDXs with combined FGFR/EGFR inhibitors was more efficient than anti-FGFR3 treatment alone.ConclusionsWe developed preclinical PDX models that recapitulate the molecular heterogeneity of MIBCs and UTUC, including actionable mutations, which will represent an essential tool in therapy development. Pharmacological characterization of the PDXs suggested that upper urinary tract and MIBCs, UCC but also SCC, with similar molecular characteristics could benefit from the same treatments including anti-FGFR for FGFR3-mutated tumors and anti-EGFR for basal ones and showed a benefit for combined FGFR/EGFR inhibition in FGFR3-mutant PDXs, compared to FGFR inhibition alone.