bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe but reversible impaired diaphragm function in septic mechanically ventilated patients
Authors: Lecronier Marie , Jung Boris , Molinari Nicolas , Pinot Jérôme , Similowski Thomas , Jaber Samir , Demoule Alexandre , Dres Martin 
Published: April 2022

Abstract
Background
Whether sepsis-associated diaphragm dysfunction may improve despite the exposure of mechanical ventilation in critically ill patients is unclear. This study aims at describing the diaphragm function time course of septic and non-septic mechanically ventilated patients.

Methods
Secondary analysis of two prospective observational studies of mechanically ventilated patients in whom diaphragm function was assessed twice: within the 24 h after intubation and when patients were switched to pressure support mode, by measuring the endotracheal pressure in response to bilateral anterior magnetic phrenic nerve stimulation (Ptr,stim). Change in diaphragm function was expressed as the difference between Ptr,stim measured under pressure support mode and Ptr,stim measured within the 24 h after intubation. Sepsis was defined according to the Sepsis-3 international guidelines upon inclusion. In a sub-group of patients, the right hemidiaphragm thickness was measured by ultrasound.

Results
Ninety-two patients were enrolled in the study. Sepsis upon intubation was present in 51 (55%) patients. In septic patients, primary reason for ventilation was acute respiratory failure related to pneumonia (37/51; 73%). In non-septic patients, main reasons for ventilation were acute respiratory failure not related to pneumonia (16/41; 39%), coma (13/41; 32%) and cardiac arrest (6/41; 15%). Ptr,stim within 24 h after intubation was lower in septic patients as compared to non-septic patients: 6.3 (4.9–8.7) cmH2O vs. 9.8 (7.0–14.2) cmH2O (p = 0.004), respectively. The median (interquartile) duration of mechanical ventilation between first and second diaphragm evaluation was 4 (2–6) days in septic patients and 3 (2–4) days in non-septic patients (p = 0.073). Between first and second measurements, the change in Ptr,stim was + 19% (− 13–61) in septic patients and − 7% (− 40–12) in non-septic patients (p = 0.005). In the sub-group of patients with ultrasound measurements, end-expiratory diaphragm thickness decreased in both, septic and non-septic patients. The 28-day mortality was higher in patients with decrease or no change in diaphragm function.

Conclusion
Septic patients were associated with a more severe but reversible impaired diaphragm function as compared to non-septic patients. Increase in diaphragm function was associated with a better survival.
Distributed resource allocation for D2D communications underlaying cellular network based on Stackelberg game
Authors: Wang Xin , Pan He , Shi Ying 
Published: April 2022

AbstractWith the development of artificial intelligence, the large-scale access of intelligence equipment with complex heterogeneity will bring unpredictable spectrum limitation and complex interferences to traditional cellular networks. This situation can be alleviated by device-to-device (D2D) technique which improves spectrum efficiency by reusing cellular resources. In this paper, a resource allocation framework comprising channel allocation and power control based on Stackelberg game is proposed for distributed interference coordination between D2D and cellular communications with quality-of-service guarantee. First, base station matches the channel to D2D pairs on the basis of potential throughput gain. Second, interferences from D2D pairs to cellular users are converted into a penalty for D2D pairs through the interlayer price, and the optimization problem of system throughput is decoupled into multiple subproblems those can be solved in distributed and iterative manner in each D2D pair. Simulation results show that two proposed distributed algorithms of channel allocation and power control on interference coordination perform well in convergence and overall system throughput.
Prevalence and associated factors of HIV testing among young (15–24) women in eastern Africa: a multilevel analysis of demographic health survey data (2008-2018)
Authors: Worku Misganaw Gebrie , Teshale Achamyeleh Birhanu , Tesema Getayeneh Antehunegn 
Published: April 2022

Abstract
Background
According to available evidence, only 15% of young women in sub-Saharan Africa know their Human immune deficiency virus (HIV) status. Despite a high prevalence of HIV infection among adolescents and young women, policymakers give less attention to HIV testing and counseling services. So, this study aimed to investigate the pooled prevalence and associated factors of HIV testing among young women in east Africa.

Methods
The most recent DHS surveys done among 11 east African countries were pooled and a weighted sample of 73,661 young women were included. At bivariable analysis variables with a p-value≤0.2 were selected for multivariable analysis and variables with a p-value of ≤0.05 in the multivariable analysis were considered as a statistically significant determinant of HIV testing.

Results
Pooled prevalence of HIV testing among young women was 55.3%: 95% CI (54.97%, 55.69%). In the multilevel multivariable analysis: respondent age, marital status, educational level, occupation, media exposure, having higher and comprehensive knowledge about HIV / AIDS, having some and higher risky sexual behavior, visiting health care facilities, being rural dweller, being from rich households, having multiple sexual partners, early sex initiation and community-level education were significantly associated with HIV testing.

Conclusion
The prevalence of HIV testing among young women was significantly affected by both individual and community-level factors. To prevent the transmission and dissemination of HIV, there should be a systematic and coordinated approach and policy for HIV testing among young people.
Long-Term Flexural Behaviour of Cracked Reinforced Concrete Beams with Recycled Aggregate
Authors: Sryh Lamen , Forth John 
Published: April 2022

AbstractThis paper presents the results of an investigation into the long-term flexural behaviour of cracked reinforced recycled aggregate concrete (RAC) beams. Washed construction and demolition wastes (CDW) with a maximum size of 20 mm were used as the coarse recycled aggregate. The main variable in the research was the replacement ratio of recycled aggregate. Specimens with 0%, 50% and 100% recycled aggregate were cast and tested. The experimental results showed that samples with an increased amount of recycled aggregate had significantly reduced strength and a noticeable increase in both short-term and long-term deflection of RAC beams over equivalent normal concrete (NC) beams. Increased levels of RA resulted in greater creep and shrinkage of RAC and greater long-term loss of tension stiffening in RAC reinforced tension specimens. Prediction of long-term deflections using Eurocode 2, even after incorporating the experimental concrete properties within the Code method, underestimated the experimental deflections of the RAC beams. However, by modifying the tension stiffening factor, β used in Eurocode 2, deflections were predicted to within approximately 1%. From this investigation, it is recommended that the factor β be reduced from 0.5 (for NC) to 0.4 (for RAC @50% replacement) and 0.3 (for RAC @100% replacement).
Role of omega-3 polyunsaturated fatty acids, citrus pectin, and milk-derived exosomes on intestinal barrier integrity and immunity in animals
Authors: Sundaram Tamil Selvi , Giromini Carlotta , Rebucci Raffaella , Pistl Juraj , Bhide Mangesh , Baldi Antonella 
Published: April 2022

AbstractThe gastrointestinal tract of livestock and poultry is prone to challenge by feedborne antigens, pathogens, and other stress factors in the farm environment. Excessive physiological inflammation and oxidative stress that arises firstly disrupts the intestinal epithelial barrier followed by other components of the gastrointestinal tract. In the present review, the interrelationship between intestinal barrier inflammation and oxidative stress that contributes to the pathogenesis of inflammatory bowel disease was described. Further, the role of naturally existing immunomodulatory nutrients such as the omega-3 polyunsaturated fatty acids, citrus pectin, and milk-derived exosomes in preventing intestinal barrier inflammation was discussed. Based on the existing evidence, the possible molecular mechanism of these bioactive nutrients in the intestinal barrier was outlined for application in animal diets.
Donor age and body weight determine the effects of fecal microbiota transplantation on growth performance, and fecal microbiota development in recipient pigs
Authors: Wang Xiaofan , Tsai Tsungcheng , Zuo Bin , Wei Xiaoyuan , Deng Feilong , Li Ying , Maxwell Charles V. , Yang Hua , Xiao Yingping , Zhao Jiangchao 
Published: April 2022

Abstract
Background
The application of fecal microbiota transplantation (FMT) to improve swine growth performance has been sporadically studied. Most of these studies used a single microbiota source and thus the effect of donor characteristics on recipient pigs’ fecal microbiota development and growth performance is largely unknown.

Results
In this study, we collected feces from six donors with heavy (H) or light (L) body weight and different ages (d 42, nursery; d 96, growing; and d 170, finisher) to evaluate their effects on the growth performance and fecal microbiota development of recipient pigs. Generally, recipients that received two doses of FMT from nursery and finisher stages donor at weaning (21 ± 2 days of age) inherited the donor’s growth pattern, while the pigs gavaged with grower stage material exerted a numerically greater weight gain than the control pigs regardless of donor BW. FMT from heavier donors (NH, GH, and FH) led to the recipients to have numerically increased growth compared to their lighter counterparts (NL, GL, and FL, respectively) throughout the growing and most finishing stages. This benefit could be attributed to the enrichment of ASV25 Faecalibacterium, ASV61 Faecalibacterium, ASV438 Coriobacteriaceae_unclassified, ASV144 Bulleidia, and ASV129 Oribacterium and decrease of ASV13 Escherichia during nursery stage. Fecal microbiota transplantation from growing and finishing donors influenced the microbial community significantly in recipient pigs during the nursery stage. FMT of older donors’ gut microbiota expedited recipients’ microbiota maturity on d 35 and 49, indicated by increased estimated microbiota ages. The age-associated bacterial taxa included ASV206 Ruminococcaceae, ASV211 Butyrivibrio, ASV416 Bacteroides, ASV2 Streptococcus, and ASV291 Veillonellaceae. The body weight differences between GL and GH pigs on d 104 were associated with the increased synthesis of the essential amino acid, lysine and methionine, mixed acid fermentation, expedited glycolysis, and sucrose/galactose degradation.

Conclusions
Overall, our study provided insights into how donor age and body weight affect FMT outcomes regarding growth performance, microbiota community shifts, and lower GI tract metabolic potentials. This study also provided guidance to select qualified donors for future fecal microbiota transplantation.
Gut microbiome signatures linked to HIV-1 reservoir size and viremia control
Authors: Borgognone Alessandra , Noguera-Julian Marc , Oriol Bruna , Noël-Romas Laura , Ruiz-Riol Marta , Guillén Yolanda , Parera Mariona , Casadellà Maria , Duran Clara , Puertas Maria C. , Català-Moll Francesc , De Leon Marlon , Knodel Samantha , Birse Kenzie , Manzardo Christian , Miró José M. , Clotet Bonaventura , Martinez-Picado Javier , Moltó José , Mothe Beatriz , Burgener Adam , Brander Christian , Paredes Roger ,   the BCN02 Study Group, Benet Susana , Brander Christian , Cedeño Samandhy , Clotet Bonaventura , Coll Pep , Llano Anuska , Martinez-Picado Javier , Marszalek Marta , Morón-López Sara , Mothe Beatriz , Paredes Roger , Puertas Maria C. , Rosás-Umbert Miriam , Ruiz-Riol Marta , Escrig Roser , Gel Silvia , López Miriam , Miranda Cristina , Moltó José , Muñoz Jose , Perez-Alvarez Nuria , Puig Jordi , Revollo Boris , Toro Jessica , Barriocanal Ana María , Perez-Reche Cristina , Farré Magí , Valle Marta , Manzardo Christian , Ambrosioni Juan , Ruiz Irene , Rovira Cristina , Hurtado Carmen , Ligero Carmen , Fernández Emma , Sánchez-Palomino Sonsoles , Miró Jose M. , Carrillo Antonio , Meulbroek Michael , Pujol Ferran , Saz Jorge , Borthwick Nicola , Crook Alison , Wee Edmund G. , Hanke Tomáš 
Published: April 2022

Abstract
Background
The potential role of the gut microbiome as a predictor of immune-mediated HIV-1 control in the absence of antiretroviral therapy (ART) is still unknown. In the BCN02 clinical trial, which combined the MVA.HIVconsv immunogen with the latency-reversing agent romidepsin in early-ART treated HIV-1 infected individuals, 23% (3/13) of participants showed sustained low-levels of plasma viremia during 32 weeks of a monitored ART pause (MAP). Here, we present a multi-omics analysis to identify compositional and functional gut microbiome patterns associated with HIV-1 control in the BCN02 trial.

Results
Viremic controllers during the MAP (controllers) exhibited higher Bacteroidales/Clostridiales ratio and lower microbial gene richness before vaccination and throughout the study intervention when compared to non-controllers. Longitudinal assessment indicated that the gut microbiome of controllers was enriched in pro-inflammatory bacteria and depleted in butyrate-producing bacteria and methanogenic archaea. Functional profiling also showed that metabolic pathways related to fatty acid and lipid biosynthesis were significantly increased in controllers. Fecal metaproteome analyses confirmed that baseline functional differences were mainly driven by Clostridiales. Participants with high baseline Bacteroidales/Clostridiales ratio had increased pre-existing immune activation-related transcripts. The Bacteroidales/Clostridiales ratio as well as host immune-activation signatures inversely correlated with HIV-1 reservoir size.

Conclusions
The present proof-of-concept study suggests the Bacteroidales/Clostridiales ratio as a novel gut microbiome signature associated with HIV-1 reservoir size and immune-mediated viral control after ART interruption.
‘When hunger makes everything better looking!’: The effect of hunger on the aesthetic appreciation of human bodies, faces and objects
Authors: Cazzato Valentina , Vicario Carmelo M. , Urgesi Cosimo 
Published: April 2022

AbstractBackgroundResearch evidence suggests that physiological state of hunger might affect preference for female body weight, such that hungrier, compared to satiate, men prefer heavier body weight and rate as more attractive heavier female figures. Here, we seek to extend these findings by comparing the effects of fasting and snack on aesthetics judgements of the bodies and faces of conspecifics and of objects in a sample of female and male participants.MethodsForty-four participants (women: n = 21, mean age = 23.70 yrs ± 0.62) provided aesthetic liking judgments of round and slim human bodies, faces and objects, under at least 12 h of overnight fasting and immediately after having eaten a snack (i.e., bananas). An anthropometric measure of adiposity (i.e., Body Mass Index, BMI) was also collected from each observer.ResultsOverall, we found that participants’ aesthetic judgements were higher for slim stimuli compared to round ones. However, after fasting, participants rated round stimuli as more attractive compared to when they had a snack. This hunger-based shift in ratings not only was apparent when stimuli depicted a human body or face, but also when they depicted an object, thus suggesting a general modification of observers’ aesthetic preference related to hunger. Importantly, this effect was modulated by participants’ BMI so that only participants with a high BMI provided higher aesthetic judgements for round stimuli after fasting than after a snack.ConclusionsOur results demonstrated that both the modification of the physiological state and the individual differences in adiposity level of the observers might affect the aesthetic appreciation of the external world.
A clustering-based topic model using word networks and word embeddings
Authors: Mu Wenchuan , Lim Kwan Hui , Liu Junhua , Karunasekera Shanika , Falzon Lucia , Harwood Aaron 
Published: April 2022

AbstractOnline social networking services like Twitter are frequently used for discussions on numerous topics of interest, which range from mainstream and popular topics (e.g., music and movies) to niche and specialized topics (e.g., politics). Due to the popularity of such services, it is a challenging task to automatically model and determine the numerous discussion topics given the large amount of tweets. Adding on this complexity is the need to identify these topics with the absence of prior knowledge about both the types and number of topics, while having the requirement of the relevant technical expertise to tune the numerous parameters for the various models. To address this challenge, we develop the Clustering-based Topic Modelling (ClusTop) algorithm that first constructs different types of word networks based on different types of n-grams co-occurrence and word embedding distances. Using these word networks, ClusTop is then able to automatically determine the discussion topics using community detection approaches. In contrast to traditional topic models, ClusTop does not require the tuning or setting of numerous parameters and instead uses community detection approaches to automatically determine the appropriate number of topics. The ClusTop algorithm is also able to capture the syntactic meaning in tweets via the use of bigrams, trigrams, other word combinations and word embedding techniques in constructing the word network graph, and utilizes edge weights based on word embedding. Using three Twitter datasets with labelled crises and events as topics, we show that ClusTop outperforms various traditional baselines in terms of topic coherence, pointwise mutual information, precision, recall and F-score.
Association between early tracheostomy and patient outcomes in critically ill patients on mechanical ventilation: a multicenter cohort study
Authors: Tanaka Aiko , Uchiyama Akinori , Kitamura Tetsuhisa , Sakaguchi Ryota , Komukai Sho , Matsuyama Tasuku , Yoshida Takeshi , Tokuhira Natsuko , Iguchi Naoya , Fujino Yuji 
Published: April 2022

Abstract
Background
Tracheostomy is commonly performed in critically ill patients because of its clinical advantages over prolonged translaryngeal endotracheal intubation. Early tracheostomy has been demonstrated to reduce the duration of mechanical ventilation and length of stay. However, its association with mortality remains ambiguous. This study aimed to evaluate the association between the timing of tracheostomy and mortality in patients receiving mechanical ventilation.

Methods
We performed a retrospective cohort analysis of adult patients who underwent tracheostomy during their intensive care unit (ICU) admission between April 2015 and March 2019. Patients who underwent tracheostomy before or after 29 days of ICU admission were excluded. Data were collected from the nationwide Japanese Intensive Care Patient Database. The primary outcome was hospital mortality. The timing of tracheostomy was stratified by quartile, and the association between patient outcomes was evaluated using regression analysis.

Results
Among the 85558 patients admitted to 46 ICUs during the study period, 1538 patients were included in the analysis. The quartiles for tracheostomy were as follows: quartile 1, ≤ 6 days; quartile 2, 7–10 days; quartile 3, 11–14 days; and quartile 4, > 14 days. Hospital mortality was significantly higher in quartile 2 (adjusted odds ratio [aOR]: 1.52, 95% confidence interval [CI]: 1.08–2.13), quartile 3 (aOR: 1.82, 95% CI: 1.28–2.59), and quartile 4 (aOR: 2.26, 95% CI: 1.61–3.16) (p for trend < 0.001) than in quartile 1. A similar trend was observed in the subgroup analyses of patients with impaired consciousness (Glasgow Coma Scale score < 8) and respiratory failure (PaO2:FiO2 ≤ 300) at ICU admission (p for trend = 0.081 and 0.001, respectively).

Conclusions
This multi-institutional observational study demonstrated that the timing of tracheostomy was significantly and independently associated with hospital mortality in a stepwise manner. Thus, early tracheostomy may be beneficial for patient outcomes, including mortality, and warrants further investigation.
Debridement, antibiotics, and implant retention in non-oncological femoral megaprosthesis infections: minimum 5 year follow-up
Authors: Asokan A. , Ibrahim M. S. , Thompson J. W. , Haddad F. S. 
Published: April 2022

Abstract
Purpose
Megaprostheses are increasingly utilised outside of the oncological setting, and remain at significant risk of periprosthetic joint infection (PJI). Debridement, antibiotic, and implant retention (DAIR) is an established treatment for PJI, however its use in non-oncological patients with femoral megaprostheses has not been widely reported. There are significant differences in patient physiology, treatment goals, and associated risks between these patient cohorts.

Methods
We identified 14 patients who underwent DAIR for a PJI of their femoral megaprostheses, between 2000 and 2014, whom had their index procedure secondary to non-oncological indications. Patients were managed as part of a multidisciplinary team, with our standardised surgical technique including exchange of all mobile parts, and subsequent antibiotic therapy for a minimum of 3 months. Patients were followed up for a minimum of 5 years.

Results
Patients included six proximal femoral replacements, five distal femoral replacements, and three total femoral replacements. No patients were lost to follow-up. There were six males and eight females, with a mean age of 67.2 years, and mean ASA of 2.3.
Nine patients (64.3%) successfully cleared their infection following DAIR at a minimum of 5 year follow-up. Five patients (35.7%) required further revision surgery, with four patients cleared of infection. No patients who underwent DAIR alone suffered complications as a result of the procedure.

Conclusions
The use of DAIR in these complex patients can lead to successful outcomes, but the risk of further revision remains high. The success rate (64.3%) remains on par with other studies evaluating DAIR in megaprostheses and in primary arthroplasty. This study indicates judicious use of DAIR can be an appropriate part of the treatment algorithm.

Level of evidence
II