bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-Year Follow-Up of Posterior Corneal Elevation in Thin Corneas After Small Incision Lenticule Extraction
Authors: Zhao Yu , Fu Dan , Chen Zhuoyi , Zhou Xingtao 
Published: February 2022

PurposeTo evaluate the changes in posterior corneal elevation in thin corneas after small incision lenticule extraction (SMILE).MethodsIn this prospective study, 97 eyes of 97 patients undergoing SMILE were recruited. Eyes were categorized into the following groups based on the preoperative minimum central corneal thickness (CCT): group A (37 eyes, 480–499 μm), group B (30 eyes, 500–529 μm), and group C (30 eyes, 530–560 μm). The posterior corneal surface was measured with a Pentacam over a 3-year follow-up period. Changes in the posterior corneal elevation at the central point (PCE), thinnest point (PTE), and predetermined area were measured.ResultsNo iatrogenic keratectasia was observed during the follow-up period. The mean changes in PCE, PTE, and the inferior area in group A were 1.14 ± 3.40 μm, −0.11 ± 3.20 μm, and −0.26 ± 1.23 μm, respectively (P ≥ 0.125). Although statistically significant change in the central-4 mm area was noted, the value was quite small (0.98 ± 1.67 μm) and was not higher than that in the other two groups (P = 0.003). For all three groups, the elevation remained stable or showed a backward change in the central annulus, while there was a small forward displacement in the 6-mm optical zone. In group A, changes in elevation values yielded negative statistical correlations with residual bed thickness and CCT (P ≤ 0.006) (except for the inferior area, the 4-mm and 6-mm optical zone).ConclusionsWith a strict preoperative assessment, SMILE achieved good safety and efficacy in correcting myopia in thin corneas and enabled a stable posterior corneal surface over a 3-year follow-up period.SynopsisCareful preoperative assessment and suitable surgical design should be taken to ensure posterior corneal stability after SMILE in thin corneas.
Impact of Superparamagnetic Iron Oxide Nanoparticles on THP-1 Monocytes and Monocyte-Derived Macrophages
Authors: Polasky Christina , Studt Tim , Steuer Ann-Kathrin , Loyal Kristin , Lüdtke-Buzug Kerstin , Bruchhage Karl-Ludwig , Pries Ralph 
Published: February 2022

Superparamagnetic iron oxide nanoparticles (SPIONs) are currently under examination for magnetic particle imaging, which represents a radiation free technology for three-dimensional imaging with high sensitivity, resolution and imaging speed. SPIONs are rapidly taken up by monocytes and other phagocytes which carry them to the site of inflammation. Therefore, the SPION biocompatibility is an essential parameter for a widespread MPI usage. Many improvements are expected from SPION development and its applications for cell visualization, but the impact of MPI optimized dextran coated SPIONs on the cellular characteristics of monocytic cells has been poorly studied up to now. THP-1 monocytes, monocyte-derived macrophages (MDM) as well as peripheral blood monocytes were incubated with MPI-optimized dextran-coated SPIONs of a size between 83.5 and 86 nm. SPION uptake was measured by FITC fluorescence of labeled SPIONs and Prussian blue staining. The activation of monocytes and MDMs was evaluated by CD14, CD11b and CD86 in flow cytometry. The secretion of IL-1β, and IL-10 was analyzed in supernatants. SPIONs were rapidly taken up by monocytes and monocyte-derived macrophages while no decrease in cell viability was observed. Expression patterns of CD11b, CD14, and CD86 were not affected in THP-1 monocytes and MDMs. Monocyte differentiation in macrophages was hindered during SPION uptake. THP-1 monocytes as well as monocyte-derived macrophages showed significantly increased IL-1β and decreased IL-10 secretion by tendency after SPION treatment. Dextran-coated SPIONs showed a low cytotoxicity on monocytes but exert undesirable inflammatory side effects that have to be considered for imaging applications.
Changes of Vestibular Symptoms in Menière's Disease After Triple Semicircular Canal Occlusion: A Long-Term Follow-Up Study
Authors: Jiang Yumeng , Xu Maoxiang , Yao Qingxiu , Li Zhuangzhuang , Wu Yaqin , Chen Zhengnong , Yu Dongzhen , Shi Haibo , Yin Shankai 
Published: February 2022

BackgroundThe clinical efficacy of triple semicircular canal occlusion (TSCO) and vestibular nerve resection (VNS) for patients with Ménière's disease has been unclear.ObjectiveTo explore changes in vestibular symptoms after TSCO and its advantages compared to the classical operation of VNS in patients with Menière's disease.MethodsIn total, 36 patients with Menière's disease performed TSCO or VNS at Shanghai Jiao Tong University Affiliated Sixth People's Hospital, China from May 2005 to July 2021, and all of them were enrolled in our study. Twelve of them underwent TSCO, 23 underwent VNS, and 1 had both treatments. We compared the demographic parameters, clinical symptoms, and selected test results between the two surgical methods. Ten patients each who underwent TSCO and VNS completed the follow-up. We collected and compared data pertaining to changes in vestibular symptoms.ResultsNo significant difference in demographic parameters, clinical symptoms, or auditory or vestibular test results was detected between the two groups preoperatively. The TSCO group with vertigo as the main complaint experienced less residual paroxysmal dizziness after surgery than the VNS group (P = 0.020). Also, 57% of the patients in the VNS group had unsteadiness after surgery, while no such problems were reported in the TSCO group (P = 0.025).ConclusionsOur study shows that TSCO controls vertigo in most Menière's disease patients, and also has the advantage of lower rates of postoperative paroxysmal dizziness and unsteadiness than VNS. Thus, TSCO may be an effective surgery for refractory Menière's disease.
Biocompatible Nanomaterials in Food Science, Technology, and Nutrient Drug Delivery: Recent Developments and Applications
Authors: Ranjha Muhammad Modassar Ali Nawaz , Shafique Bakhtawar , Rehman Abdur , Mehmood Arshad , Ali Ahmad , Zahra Syeda Mahvish , Roobab Ume , Singh Ajay , Ibrahim Salam A. , Siddiqui Shahida Anusha 
Published: February 2022

Graphical AbstractGraphical abstract of functions of biocompatible nanomaterials in food industry.
The Diagnostic Performance of Machine Learning-Based Radiomics of DCE-MRI in Predicting Axillary Lymph Node Metastasis in Breast Cancer: A Meta-Analysis
Authors: Zhang Jing , Li Longchao , Zhe Xia , Tang Min , Zhang Xiaoling , Lei Xiaoyan , Zhang Li 
Published: February 2022

ObjectiveThe aim of this study was to perform a meta‐analysis to evaluate the diagnostic performance of machine learning(ML)-based radiomics of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) DCE-MRI in predicting axillary lymph node metastasis (ALNM) and sentinel lymph node metastasis(SLNM) in breast cancer.MethodsEnglish and Chinese databases were searched for original studies. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) and Radiomics Quality Score (RQS) were used to assess the methodological quality of the included studies. The pooled sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC) were used to summarize the diagnostic accuracy. Spearman’s correlation coefficient and subgroup analysis were performed to investigate the cause of the heterogeneity.ResultsThirteen studies (1618 participants) were included in this meta-analysis. The pooled sensitivity, specificity, DOR, and AUC with 95% confidence intervals were 0.82 (0.75, 0.87), 0.83 (0.74, 0.89), 21.56 (10.60, 43.85), and 0.89 (0.86, 0.91), respectively. The meta-analysis showed significant heterogeneity among the included studies. There was no threshold effect in the test. The result of subgroup analysis showed that ML, 3.0 T, area of interest comprising the ALN, being manually drawn, and including ALNs and combined sentinel lymph node (SLN)s and ALNs groups could slightly improve diagnostic performance compared to deep learning, 1.5 T, area of interest comprising the breast tumor, semiautomatic scanning, and the SLN, respectively.ConclusionsML-based radiomics of DCE-MRI has the potential to predict ALNM and SLNM accurately. The heterogeneity of the ALNM and SLNM diagnoses included between the studies is a major limitation.
A Risk Model Composed of Complete Blood Count, BRAF V600E and MAP2K1 Predicts Inferior Prognosis of Langerhans Cell Histiocytosis in Children
Authors: Wang Leyuan , Yuan Lin , Du Xizi , Zhou Kai , Yang Yu , Qin Qingwu , Yang Liangchun , Xiang Yang , Qu Xiangping , Liu Huijun , Qin Xiaoqun , Liu Chi 
Published: February 2022

BackgroundIn children, Langerhans cell histiocytosis (LCH), which is the most prevalent histiocytic disorder, exhibits a wide variety of manifestations and outcomes. There is no standard prognosis evaluation system for LCH. We investigated the combined predictive significance of complete blood counts (CBCs), BRAF V600E and MAP2K1 in childhood LCH.MethodsA cohort of 71 childhood LCH patients was retrospectively studied. The prognosis predictive significance of platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI), systemic immune inflammation index (SII), BRAF V600E, and MAP2K1 were analyzed.ResultsHistiocyte Society (HS) classification of LCH patients was correlated with NLR, SIRI, and progression free survival (PFS), bone involvement was correlated with SIRI, liver involvement was correlated with NLR, SII, SIRI, and PFS, spleen involvement was correlated with SIRI, lung involvement was correlated with NLR and PFS, CNS involvement was correlated with PFS, while BRAF V600E was correlated with PLR, NLR, SIRI, SII, PFS, and OS (p &lt;0.05). MAP2K1 was correlated with NLR, SIRI, PFS, and OS (p &lt;0.05). Elevated NLR, PLR SIRI, and SII predicted inferior PFS and OS (p &lt;0.05). PLR, NLE, SIRI, SII, BRAF V600E, and MAP2K1 were used to establish a risk model for stratifying the LCH patients into 3 different risk groups. Respective median PFS for low-, mediate-, and high-risk groups were not reached, 26, and 14 months (p &lt;0.001), and all median OS were not reached (p &lt;0.001).ConclusionThe risk model combined with CBCs, BRAF V600E, and MAP2K1 might be a promising prognostic system for LCH in children.
Locoregional Control and Survival in Children, Adolescents, and Young Adults With Localized Head and Neck Alveolar Rhabdomyosarcoma—The French Experience
Authors: Machavoine Roxane , Helfre Sylvie , Bernier Valérie , Bolle Stéphanie , Leseur Julie , Corradini Nadège , Rome Angélique , Defachelles Anne-Sophie , Deneuve Sophie , Bernard Sophie , Fayoux Pierre , Nicollas Richard , Mondain Michel , Luscan Romain , Denoyelle Françoise , Simon François , Kadlub Natacha , Kolb Fréderic , Honart Jean-François , Orbach Daniel , Minard-Colin Véronique , Moya-Plana Antoine , Couloigner Vincent 
Published: February 2022

IntroductionThe head and neck (HN) are the most frequent sites of pediatric rhabdomyosarcoma (RMS). Alveolar RMS (ARMS) represents ~20% of all RMS cases and frequently spread to lymph nodes (LNs). The aim was to report locoregional control, event-free survival (EFS), and overall survival (OS), according to clinical and pathological features, LN staging, and treatment modalities.MethodsThe study included all patients prospectively enrolled in EpSSG RMS 2005 study under 21 years of age with localized HN ARMS and diagnosed between 2005 and 2016 in France. Medical data including imaging, surgical report, and radiation therapy planes were analyzed.ResultsForty-eight patients (median age 6 years; range 4 months−21 years), corresponding to 30 parameningeal and 18 non-parameningeal ARMS, were included. There were 33 boys (69%). Tumor locations included the following: orbit (n = 7) among which four cases had bone erosion, paranasal sinuses and nasal cavity (n = 16), deep facial spaces (n = 10), nasolabial fold (n = 8), and other non-parameningeal HN sites (n = 7). A fusion transcript of PAX3-FOXO1 or PAX7-FOXO1 was expressed in 33 of the 45 cases (73%) with molecular analysis. At diagnosis, 10 patients had primary resection of the primary tumor (PRPT) (none with microscopic complete resection) and 9 had LN staging. After induction chemotherapy, 26 patients (54%) had secondary resection of the primary tumor (SRPT) and 13 patients (27%) had cervical LN dissection. A total of 43 patients (90%) were treated with radiation therapy.With a median follow-up of 7 years (range 2–13 years), 5-year OS and EFS were 78% (95% CI, 63–88%) and 66% (95% CI, 51–78%), respectively. We observed 16 events (10 deaths): 4 local, 4 regional, 1 local and regional, and 7 metastatic. In univariate analysis, OS was only superior for patients under 10 years of age (p = 0.002), while FOXO1-negative ARMS, SRPT for parameningeal ARMS, and LN surgery were associated with significantly better EFS.ConclusionOur study confirms a better outcome for fusion-negative ARMS and ARMS in children under 10 years. Moreover, LN surgery and SRPT of parameningeal tumor may improve EFS of ARMS. Larger studies are needed to confirm our findings.
Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice
Authors: Liu Haihua , Zheng Wenlong , Zhang Ling , Lin Tangtang , Tang Yang , Hu Ling 
Published: February 2022

Many reports have shown that patients with Hp-associated chronic gastritis exhibit anxiety and poor sleep quality. However, less is known about the effects and specific manifestations of Hp-associated chronic gastritis on autonomous activity and sleep quality in animals. Here, we investigated the effect of Helicobacter pylori (Hp)-associated chronic gastritis on autonomous activity and sleep quality in mice. To do this, a Hp-associated chronic gastritis mouse model was first established, then analyzed for autonomous activity, relative to controls, for 15 min using an autonomous activity tester. Next, sleep quality of mice was detected by sodium pentobarbital-induced sleep experiment and results compared between groups. The results showed that male mice in the model group exhibited higher activity counts but lower forelimb lift counts, relative to those in the control group, although there were no significant differences (all p &gt; .05). Conversely, female mice in the model group recorded lower activity counts, albeit at no significant difference (p &gt; .05), and significantly lower counts of forelimb lift (p &lt; .05), relative to those in the control group. Notably, male mice in the model group had longer sleep latency and shorter sleep duration than those in the control group, albeit at no significant differences (all p &gt; .05). On the other hand, female mice in the model group recorded significantly longer sleep latency as well as shorter sleep duration compared to those in the control group (all p &lt; .01). We conclude that Hp-associated chronic gastritis exerts certain effects on autonomous activity and sleep quality of mice in a gender-dependent manner. Notably, female mice with Hp-associated chronic gastritis had lower activity and forelimb lift counts, as well as prolonged sleep latency, and shortened sleep duration. These effects were all statistically significant except for activity counts.
Measurements of Atmospheric Water Vapor by a 1.316 μm Optical Fiber Laser Heterodyne Radiometer
Authors: Huang Jun , Huang Yinbo , Lu Xingji , Liu Dandan , Yuan Zihao , Qi Gang , Cao Zhensong 
Published: February 2022

A passive optical fiber laser heterodyne radiometer prototype with a semiconductor laser near 1.316 μm as the local oscillator was built, parameters of the prototype have been optimized. Using the prototype, the water vapor concentration in the atmospheric column was measured with a spectral resolution of 0.009 cm−1 in late October and early November of 2020, the collection time was approximately 3 min, and the signal-to-noise ratio was better than 120. The water vapor column concentration and profiles were inversed based on the optimal estimation method. Compared with the measurement of the Fourier transform spectrometer (EM27/SUN) which was performed simultaneously, the inversion results deviated by less than 14%, and the variation trend of the water vapor concentration showed good consistency. It is demonstrated that the 1.316 μm optical fiber laser heterodyne radiometer possesses good stability and accuracy in the field measurement of atmospheric water vapor concentration.
Participating in Longitudinal Observational Research on Psychiatric Rehabilitation: Quantitative Results From a Patient Perspective Study
Authors: Dehn Lorenz B. , Driessen Martin , Steinhart Ingmar , Beblo Thomas 
Published: February 2022

BackgroundLongitudinal observational studies play on an important role for evidence-based research on health services and psychiatric rehabilitation. However, information is missing about the reasons, why patients participate in such studies, and how they evaluate their participation experience.MethodsSubsequently to their final assessment in a 2-year follow-up study on supported housing for persons with severe mental illness, n = 182 patients answered a short questionnaire on their study participation experience (prior experiences, participation reasons, burden due to study assessments, intention to participate in studies again). Basic respondent characteristics as well as symptom severity (SCL-K9) were also included in the descriptive and analytical statistics.ResultsTo help other people and curiosity were cited as the main initial reasons for study participation (&gt;85%). Further motives were significantly associated with demographic and/or clinical variables. For instance, “relieve from boredom” was more frequently reported by men and patients with substance use disorders (compared to mood disorders), and participants ‘motive” to talk about illness” was associated with higher symptom severity at study entry. Furthermore, only a small proportion of respondents indicated significant burdens by study participation and about 87% would also participate in future studies.ConclusionsThe respondents gave an overall positive evaluation regarding their participation experience in an observational study on psychiatric rehabilitation. The results additionally suggest that health and social care professionals should be responsive to the expectations and needs of patients with mental illness regarding participation in research.
Framing Public Opinion on Physician-Patient Conflicts on Microblog: A Comparative Content Analysis
Authors: Gong Wanqi , Guo Qin 
Published: February 2022

IntroductionPhysician–patient conflicts in China have increased more than ten times from the 2000s to the 2020 and arouse heated discussions on microblog. The outbreak of the COVID-19 pandemic is believed to have brought a turnaround in the physician–patient relationship. However, little is known about the similarities and differences among the views of opinion leaders from the general public, physicians, and media regarding physician–patient conflict incidents on microblog, and whether the outbreak had an impact on this.ObjectiveThis study aims to explore how opinion leaders from the physicians, general public, and media framed posts on major physician–patient conflict incidents on microblog, and compare the microblog post frames before and after the COVID-19 pandemic. The findings will provide more objective evidence of the attitudes and perspectives of the health professionals, general public, and media on physician–patient conflicts, and the influence of pandemics on physician–patient relationship.MethodsA comparative content analysis was conducted to examine the posts (n = 941) of microblog opinion leaders regarding major physician–patient conflicts in China from 2012 to 2020.ResultsPost-pandemic microblog posts used more cooperation, positive and negative frames, but mentioned less health-related knowledge; no difference was found in the use of conflict and attribution frames. Results on the use of frames by opinion leaders from different communities found that the media used more conflict, cooperation, attribution, and positive frames, but used fewer negative frames and mentioned less health-related knowledge than general public and physicians. Results on the use of frames for different incidents found that incidents of violence against physicians used more cooperation, positive and negative frames and mentioned less health-related knowledge; in the contract, incidents of patient death used more attribution frames and mentioned more health-related knowledge.ConclusionThe physician and general public opinion leaders share some similarities in their post frames, implying that no fundamental discrepancy between them regarding physician–patient conflict incidents. However, the imbalanced use of frames by media microblogger would cultivate and reinforce the public perception of physician–patient contradictions. After the COVID-19 pandemic, more cooperation and positive frames were used in the posts, indicating an improvement in the physician–patient relationship in China.
HYPNOBREASTFEEDING, STARTING EXCLUSIVE BREASTFEEDING TO BE SUCCESS
Authors: Armini Ni Wayan 
Published: February 2022

Abstract: Mother's Milk is the best food for infants, but often a bottleneck in exclusive breastfeeding. Various factors contributed to the failure of exclusive breastfeeding, one of which is the production of milk slightly. Hypnobreastfeeding help mothers to ensure that breastfeeding mothers can continue breastfeeding, minimal exclusively during the first six months, especially if the breast-feeding mothers must return to work.. Hypnobreastfeeding are relaxation techniques to help smooth the process of breastfeeding . The trick insert sentences positive affirmations that help breastfeeding when mothers are relaxed or very concentrated on one thing. This article aims to provide an overview of hypnobreastfeeding can provide solutions to augment milk production in breastfeeding and overcome obstacles . Expected every mother is able to provide exclusive breastfeeding to their babies without significant barriers. Keywords: Exlusive breastfeeding, hypnobreastfeeding, affirmation, relaxation
Keputihan pada wanita
Authors: Marhaeni Gusti Ayu 
Published: February 2022

Abstract. Leucorrhea is a condition that is often suffering by women throughout the life cycle starting from adolescence, the reproductive period or menopause. Leucorrhea divided into two types: normal vaginal discharge or physiological and pathological abnormal. Abnormal vaginal discharge or a physiologically occurs in accordance with the female reproductive cycle or in accordance with the cycle of a woman's body with this type of expenditure is actually clear, odorless not excessive and does not cause itching or burning. While the pathological or abnormal vaginal discharge is characterized by the amount of release that much, such as sour milk, yellow or greenish, itching, burning, with a fishy smell or bad odor. The color of the vagina will be different according to the cause of vaginal discharge. The most common cause of abnormal vaginal leucore is: bacteria, fungi and parasites. Prevention of vaginal leucore the most important thing to do is maintain the cleanliness of the reproductive organs in the right way, a balance between activity and rest, reduce the of vaginal discharge are bacteria, fungi and parasite and also maintaining psycologycal stress. The purpose of this paper to discover the causes of vaginal leucorrhea. Method used was to search literature related leucorrhea. The search results show the causes are bacteria, fungi and paracites. Keywords: leucorrhea, vaginal discharge, woman