bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospect of core-shell Fe3O4@Ag label integrated with spin-valve giant magnetoresistance for future point-of-care biosensor
Authors: Wibowo Nur Aji , Harsojo  , Suharyadi Edi 
Published: January 2022

Abstract
Magnetic-based biosensors are the analytical instruments that convert the biological recognition into the electrical signal through the generating of the stray-field of the magnetic nanoparticles (MNPs) attached to the biomolecule target. The magnetic biosensor feature relies on the transducer and the MNPs label selection. Recently, the biosensor with a point-of-care feature is the most expected device in the nowadays medical diagnostic field. So that, a review of the recent research related to the novel integration of magnetoresistance-based transducers with MNPs for biosensor application is vital for the point-of-care diagnostic development. Hence, the basic principle of biosensors and the giant magnetoresistance (GMR) with exchange bias phenomena are introduced. Furthermore, we provide a review of the cutting edge method in GMR biosensor with spin-valve structure (SV-GMR) which is integrated to MNPs for biomolecule labelling. As review results, among the nano-sized magnetoresistance transducer, the SV-GMR has some predominance, i.e. electrical robustness and moderate magnetoresistance ratio. Meanwhile, as compared to the other proposed MNPs such as pure Fe3O4, Fe2O3, and hybrid Fe3O4-graphene, the core-shell Fe3O4@Ag is potent to be used, which offers not only moderate saturation magnetisation but also good protein affinity, antimicrobial activity, and minimal cytotoxicity. According to the sensor performance comparison, the usage of Fe3O4@Ag for biomolecule labelling in synergy with SV-GMR transducer is prospective to be developed. The Ag shell espouses the protein immobilisation to the surface of the MNPs label that improves the sensor sensitivity. Furthermore, the SV-GMR possessed two modes of the Fe3O4@Ag rapid detection, which are through the moderate voltage change and the switching field shifting. Meanwhile, the concentration increase of Fe3O4@Ag can be well quantified. Moreover, the Fe3O4@Ag/SV-GMR system had a low operating magnetic field with rapid data collection. In conclusion, the Fe3O4@Ag/SV-GMR biosensor system is believed to be applied as a real-time, portable, and cost-effective biosensor.
Roadmap on soft robotics: multifunctionality, adaptability and growth without borders
Authors: Mazzolai Barbara , Mondini Alessio , Del Dottore Emanuela , Margheri Laura , Carpi Federico , Suzumori Koichi , Cianchetti Matteo , Speck Thomas , Smoukov Stoyan K , Burgert Ingo , Keplinger Tobias , Siqueira Gilberto De Freitas , Vanneste Felix , Goury Olivier , Duriez Christian , Nanayakkara Thrishantha , Vanderborght Bram , Brancart Joost , Terryn Seppe , Rich Steven I , Liu Ruiyuan , Fukuda Kenjiro , Someya Takao , Calisti Marcello , Laschi Cecilia , Sun Wenguang , Wang Gang , Wen Li , Baines Robert , Patiballa Sree Kalyan , Kramer-Bottiglio Rebecca , Rus Daniela , Fischer Peer , Simmel Friedrich C , Lendlein Andreas 
Published: January 2022

AbstractSoft robotics aims at creating systems with improved performance of movement and adaptability in unknown, challenging, environments and with higher level of safety during interactions with humans. This Roadmap on Soft Robotics covers selected aspects for the design of soft robots significantly linked to the area of multifunctional materials, as these are considered a fundamental component in the design of soft robots for an improvement of their peculiar abilities, such as morphing, adaptivity and growth. The roadmap includes different approaches for components and systems design, bioinspired materials, methodologies for building soft robots, strategies for the implementation and control of their functionalities and behavior, and examples of soft-bodied systems showing abilities across different environments. For each covered topic, the author(s) describe the current status and research directions, current and future challenges, and perspective advances in science and technology to meet the challenges.
Visceral obesity with and without metabolic syndrome: incidence and clinical impact in esophageal adenocarcinoma treated with curative intent
Authors: Elliott Jessie A , Donlon Noel E , Beddy Peter , Donohoe Claire L , Doyle Suzanne L , King Sinead , Ravi Narayanasamy , Reynolds John V 
Published: January 2022

Abstract
Visceral obesity (VO) and metabolic syndrome (MetS) are risk factors for esophageal adenocarcinoma (EAC); however, their impact on operative and oncological outcomes is unclear. The aim of this study was to determine the incidence of VO and MetS among patients with EAC, and to assess their independent impact on operative and oncological outcomes. A total of 454 consecutive patients undergoing treatment with curative intent were studied. Total, subcutaneous, visceral fat area (VFA), and lean body mass (LBM) were measured by computed tomography pretreatment, with VO defined as VFA &gt;163.8cm2 for men and 80.1cm2 for women. MetS was defined per the ATPIII definition. Multivariable logistic and Cox proportional hazards regression were utilized to determine independent predictors of oncologic and operative outcomes. A total of 227 patients (50.0%) had VO. A total of 134 (30%) overall had MetS, 44% in the VO cohort. VO was associated with Barrett’s esophagus (P = 0.002) and lower cT (P = 0.006) and cN stage (P = 0.011), and improved disease-specific (P = 0.021) and overall survival (P = 0.012). No survival benefit existed for patients with VO who also had MetS. For operative complications, neither VO nor MetS increased the severity of complications, or mortality. However, VO was significantly (P = 0.035) associated with anastomotic leak and pneumonia (P = 0.037). MetS alone did not increase complication risk. VO increases specific major operative complications with no increase in mortality. VO improved survival, mainly relating to earlier stage disease; however, co-existent MetS abrogated this benefit. These seemingly paradoxical outcomes highlight manageable and potentially targetable perioperative challenges in the context of an overall favorable oncologic vista.
Cardiovascular complications of mantle field radiation: a case series
Authors: Prashar Abhisheik , Shim So-Jung , Esber Yamema , Epstein Jessica , Maheepala Krishan , Rees David 
Published: January 2022

Abstract

Background
Mantle field radiotherapy has been known to cause cardiovascular complications even years after therapy. Complications include pericardial disease, coronary artery disease, and conduction abnormalities.

Case summary
We present a case series of two patients who developed cardiovascular complications years after receiving mantle radiation. Patient 1 is a 52-year-old man who presented with symptoms of heart failure. He had a neurostimulator which precluded him from cardiac magnetic resonance imaging. Haemodynamic findings on right heart catheterization raised suspicion for constrictive pericarditis and pericardiectomy was performed. Histopathological analysis reported dense, sclerotic fibrous tissue consistent with radiation-related changes. Patient 2 is a 37-year-old man with a 2-month history of chest pain and exertional dyspnoea who was admitted for management of coronary artery disease. Coronary angiography demonstrated bilateral subclavian artery stenosis and an elevated left ventricular end-diastolic pressure (50 mmHg). He had bilateral percutaneous subclavian artery stenting. Both patients had complete resolution of symptoms on follow-up.

Discussion
Our case series emphasizes the need for an index of suspicion for radiation-related cardiovascular changes in patients who have a history of mantle radiation, especially in younger patients. This was especially pertinent in the case of our first patient who presented a diagnostic challenge due to certain patient factors. Our second patient is a case of subclavian artery stenosis which is less frequently reported as a complication of mantle radiation in the literature.
The effects of lender of last resort on financial intermediation during the great depression in Japan
Authors: Imai Masami , Okazaki Tetsuji , Sawada Michiru 
Published: January 2022

Abstract
The Bank of Japan (BOJ) expanded its liquidity provision in response to a series of financial panics from 1931–1932; however, the BOJ restricted its lending mostly to correspondent banks. We use the BOJ’s preferential treatment of correspondent banks as a quasi-experimental setting to examine the impact of central bank lending on financial intermediation. We find that deposits and loans did not fall as fast for correspondent banks as for other banks during the panic period. Furthermore, correspondent banks were less likely to be closed. The results suggest that central banks’ liquidity provision plays a critical backstop role during financial stringency.
Contemporary clinical management of monomorphic idiopathic premature ventricular contractions: results of the European Heart Rhythm Association survey
Authors: Sorgente Antonio , Farkowski Michal M , Iliodromitis Konstantinos , Guerra José M , Jubele Kristine , Chun Julian K R , de Asmundis Carlo , Boveda Serge 
Published: January 2022

Abstract
On behalf of the European Heart Rhythm Association, we designed a survey, whose aim was to understand the trend(s) in the clinical management of idiopathic monomorphic premature ventricular contractions (PVCs) among European cardiologists and cardiac electrophysiologists. A total of 202 participants in the survey answered 27 multiple-choice questions on the clinical presentation, diagnosis and treatment of idiopathic monomorphic PVCs. The most common symptom in patients with idiopathic monomorphic PVCs is palpitations, according to the majority of responders (87%), followed by fatigue (29%) and dizziness (18%). Complete blood cell count, renal function with electrolytes levels, and thyroid function are the blood tests requested by the majority of respondents (65%, 92%, and 93%, respectively). Coronary artery disease and structural heart disease needs to be ruled out, according to the vast majority of participants (99%). A 24-h Holter ECG is the preferred ECG modality to assess the burden of PVCs (86% of respondents). Among the different option treatments, beta-blockers and class I antiarrhythmic drugs are by far (81% of respondents) the preferred pharmacological option in comparison with calcium antagonists and class III antiarrhythmic drugs. Catheter ablation has also a good reputation: 99% of responders are keen to use it, especially in patients with high burden of PVCs and when signs of cardiomyopathy occur.
Digitization of Museum Collections and Copyright – Report on the International Conference ‘When Museums Go Online’, University of Geneva, 11 December 2020
Authors: Bayrou Anaïs 
Published: January 2022

Abstract
The digitization of museum collections raises a number of legal issues in copyright, which museums are often not aware of or are unclear about. This International Conference, held at and led by the University of Geneva, aimed to clarify these copyright issues and strengthen the dialogue between professionals dealing with digital cultural heritage worldwide. This event also launched the Policy Paper ‘Digitization of Digital Cultural Heritage and Copyright’, which was drafted by a group of scholars from different universities and institutions, and has been published on a dedicated website. It contains policy recommendations to lawmakers and policymakers, as well as a code of conduct and an alternative dispute resolution mechanism addressed to museum professionals.
Chromosome-level genome sequence assembly and genome-wide association study ofMuscadinia rotundifoliareveal the genetics of 12 berry-related traits
Authors: Park Minkyu , Vera Daniel , Kambrianda Devaiah , Gajjar Pranavkumar , Cadle-Davidson Lance , Tsolova Violeta , El-Sharkawy Islam 
Published: January 2022

AbstractVitis has two subgenera: Euvitis, which includes commercially important Vitis vinifera and interspecific hybrid cultivars, and Muscadinia. Of note, the market for Muscadinia grapes remains small, and only Muscadinia rotundifolia is cultivated as a commercial crop. To establish a basis for the study of Muscadinia species, we generated chromosome-level whole-genome sequences of Muscadinia rotundifolia cv. Noble. A total of 393.8 Mb of sequences were assembled from 20 haploid chromosomes, and 26 394 coding genes were identified from the sequences. Comparative analysis with the genome sequence of V. vinifera revealed a smaller size of the M. rotundifolia genome but highly conserved gene synteny. A genome-wide association study of 12 Muscadinia berry-related traits was performed among 356 individuals from breeding populations of M. rotundifolia. For the transferability of markers between Euvitis and Muscadinia, we used 2000 core genome rhAmpSeq markers developed to allow marker transferability across Euvitis species. A total of 1599 (80%) rhAmpSeq markers returned data in Muscadinia. From the GWAS analyses, we identified a total of 52 quantitative trait nucleotides (QTNs) associated with the 12 berry-related traits. The transferable markers enabled the direct comparison of the QTNs with previously reported results. The whole-genome sequences along with the GWAS results provide a new basis for the extensive study of Muscadinia species.
Convergence of the EBT method for a non-local model of cell proliferation with discontinuous interaction kernel
Authors: Gwiazda Piotr , Miasojedow Błażej , Skrzeczkowski Jakub , Szymańska Zuzanna 
Published: January 2022

AbstractWe consider the EBT algorithm (a particle method) for the nonlocal equation with a discontinuous interaction kernel. The main difficulty lies in the low regularity of the kernel, which is not Lipschitz continuous, thus preventing the application of standard arguments. Therefore, we use the radial symmetry of the problem instead and transform it using spherical coordinates. The resulting equation has a Lipschitz kernel with only one singularity at zero. We introduce a new weighted flat norm and prove that the particle method converges in this norm. We also comment on the two-dimensional case that requires the application of the theory of measure spaces on general metric spaces and present numerical simulations confirming the theoretical results. In a companion paper we apply the Bayesian method to fit parameters to this model and study its theoretical properties.
On the pivotal role of water potential to model plant physiological processes
Authors: De Swaef Tom , Pieters Olivier , Appeltans Simon , Borra-Serrano Irene , Coudron Willem , Couvreur Valentin , Garré Sarah , Lootens Peter , Nicolaï Bart , Pols Leroi , Saint Cast Clément , Šalagovič Jakub , Van Haeverbeke Maxime , Stock Michiel , wyffels Francis 
Published: January 2022

AbstractWater potential explains water transport in the soil–plant–atmosphere continuum (SPAC), and is gaining interest as connecting variable between ‘pedo-, bio- and atmosphere’. It is primarily used to simulate hydraulics in the SPAC, and is thus essential for studying drought effects. Recent implementations of hydraulics in large-scale terrestrial biosphere models (TBMs) improved their performance under water-limited conditions, while hydraulic features of recent detailed functional–structural plant models (FSPMs) open new possibilities for dissecting complex traits for drought tolerance. These developments in models across scales deserve a critical appraisal to evaluate its potential for wider use in FSPMs, but also in crop systems models (CSMs), where hydraulics are currently still absent. After refreshing the physical basis, we first address models where water potential is primarily used for describing water transport along the transpiration pathway from the soil to the leaves, through the roots, the xylem and the leaf mesophyll. Then, we highlight models for three ecophysiological processes, which have well-recognized links to water potential: phloem transport, stomatal conductance and organ growth. We identify water potential as the bridge between soil, root and shoot models, as the physiological variable integrating below- and above-ground abiotic drivers, but also as the link between water status and growth. Models making these connections enable identifying crucial traits for ecosystem resilience to drought and for breeding towards improved drought tolerance in crops. Including hydraulics often increases model complexity, and thus requires experimental data on soil and plant hydraulics. Nevertheless, modelling hydraulics is insightful at different scales (FSPMs, CSMs and TBMs).
Management of Hydrocarbon Burns: Considering Mental Health and Biochemical Abnormalities
Authors: Rudduck Emma-Leigh , Concannon Elizabeth , Coghlan Patrick , Govindan Thiru , Kurmis Rochelle , Solanki Nicholas 
Published: January 2022

Abstract
Volatile substance misuse, particularly the inhalation of hydrocarbons, is a growing issue globally. Consequences of volatile substance misuse, both acute and chronic cause cardiovascular, respiratory, renal, metabolic, and central nervous system damage. Whilst the effects of hydrocarbon abuse have been reported, the combination of intoxication with hydrocarbon and burns sustained has not yet been presented. A retrospective case series of patients who presented in the last 5 years to the Royal Adelaide Hospital with hydrocarbon-related burns in the context of illicit use was undertaken. Our aims are to present to the wider scientific community the high morbidity and mortality of hydrocarbon burn injuries and why this tertiary Burns Unit feel it most appropriate to medically stabilize these patients prior to definitive surgery for their burn. All patients that presented with acute hydrocarbon intoxication and sustained concomitant burns had significant psychiatric disorder and substance abuse history and three of five had either not eaten in several days resulting in acute malnourishment, refeeding syndrome or had evidence of chronic malnourishment with deranged electrolytes and hypoalbuminemia. Their definitive burns surgery was delayed where appropriate in order to facilitate medical stabilization as they were too high risk of cardiac membrane instability, electrolyte derangement, and/or respiratory compromise to undergo safe general anesthetic and burns debridement. We propose a multidisciplinary team approach, utilizing not only our Burns Unit care model of physiotherapists, psychologists, social work, and burns trained nurses and surgeons but also Intensive Care, Toxicology, Addiction medicine and General Medical physicians in the management of these patients.
A Retrospective Review of Emergency Department Visits That May Be Appropriate for Management in Non-Emergency Settings
Authors: Tapia Ashley D , Howard Jeffrey T , Bebo Natasha L , Pfaff James A , Chin Eric J , Trueblood Wesley A , April Michael D , Long Brit J , Long Adrianna N , Fernandez William G , Schauer Steven G 
Published: January 2022

ABSTRACTBackgroundEmergency departments (EDs) continue to struggle with overcrowding, increasing wait times, and a surge in patients with non-urgent conditions. Patients frequently choose the ED for non-emergent medical issues or injuries that could readily be handled in a primary care setting. We analyzed encounters in the ED at the Brooke Army Medical Center—the largest hospital in the Department of Defense—to determine the percentage of visits that could potentially be managed in a lower cost, appointment-based setting.Materials and MethodsWe conducted a retrospective chart review of patients within our electronic medical record system from September 2019 to August 2020, which represented equidistance from the start of the COVID-19 pandemic, resulting in a shift in ED used based on previously published data. Our study also compared the number of ED visits pre-covid vs. post-covid. We defined visits to be primary care eligible if they were discharged home and received no computed tomography imaging, ultrasound, magnetic resonance imaging, intravenous medications, or intramuscular-controlled substances.ResultsDuring the 12 month period, we queried data on 75,205 patient charts. We categorized 56.7% (n = 42,647) of visits as primary care eligible within our chart review. Most primary-care-eligible visits were ESI level 4 (59.2%). The largest proportion of primary-care-eligible patients (28.3%) was seen in our fast-track area followed by our pediatric pod (21.9%). The total number of ED visits decreased from 7,477 pre-covid to 5,057 post-covid visits. However, the proportion of patient visits that qualified as primary care eligible was generally consistent.ConclusionsOver half of all ED visits in our dataset could be primary care eligible. Our findings suggest that our patient population may benefit from other on-demand and appointment-based healthcare delivery to decompress the ED.
One-loop contributions to the decay H → νl̅νlγ in the Standard Model revisited
Authors: Phan Khiem Hong , Tran Dzung Tri 
Published: January 2022

Abstract
One-loop contributions to the decay H → νl̅νlγ with l = e, μ, τ within the Standard Model framework are revisited in this paper. We derive two representations for the form factors in this calculation. As a result, the computations are not only checked numerically by verifying the ultraviolet finiteness of the results but also confirming the ward identity of the amplitude. We find that the results have good stability with varying ultraviolet cutoff parameters as well as satisfying the ward identity. In phenomenological results, we study the partial decay widths for the decay channels in the two cases of the detected photon and invisible photon. Differential decay widths are also generated as a function of the energy of the final photon.