bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESKİ ÇAĞ’DA KAFKASYA MADENCİLİĞİNİN GELİŞİMİ VE ARTVİN
Authors: KÜÇÜKYILDIZ İshak 
Published: July 2022

Karadeniz ve Hazar Denizi arasında dağlık bir yapıya sahip olan Kafkasya, Karadeniz’in kuzeydoğusunda bulunan Tamam Yarımadası’ndan, Hazar Denizi’nin batısındaki Apşeron Yarımadası’na kadar uzanan alana verilen isimdir. Antik Yakındoğu’nun en büyük kültür ve metalürjik bölgelerinden biri olan Kafkasya, Orta Tunç Çağı’ndan itibaren Antik Dönem metalciliği açısından oldukça önemli bir veri ortaya koymaktadır. Kafkasya bölgesinde metal üreticiliğine dair en erken kanıtların Erken Eneolitik (Kalkolitik) dönemden itibaren saptanabildiği anlaşılmaktadır. Bölgesinin en eski metal eserleri Orta Transkafkasya’daki yerleşimlerde ortaya çıkmıştır. Söz konusu bu metal eserler, Orta ve Doğu Transkafkasya’nın Şulaveri-Şomu Tepe Kültürü yerleşim tabakalarında tespit edilmiştir. Güneydoğu Gürcistan’da Kura-Khramis Didi Gora ve Arukhlo/Nakhiduri I ile Azerbaycan’ın batısındaki Gargalar Tepesi bu yerleşimlerden bir kısmıdır. Kafkasya’da ilk bakır metalürjisinin gelişimi için gerekli olan hammaddenin ana kaynağı olarak Orta Transkafkasya’nın güney bölgesi düşünülmektedir. Ancak bu bilgiyi doğrulayacak yeterli veriye ulaşılamamıştır.
Antik kaynaklarda Kolhis Bölgesi içerisinde zikredilen Artvin ve çevresi, antik yazarlar tarafından “Altın Zengini Ülke” olarak zikredilmiştir. Kolhis’in tunç metalürjisi Çoruh Havzası, Abhazya ve Racha-Lechkhumi adlı bölgeler üzerinde incelenmiştir. Buralarda üretilen malların yerli halkın kullanımından başka komşu ülkelere ihracatı da yapılmaktaydı. Ayrıca Kolhis Bölgesi’nde zengin demir yatakları da bulunmaktaydı. Günümüz MTA raporlarına göre Artvin, madencilik açısından oldukça zengin olmasına rağmen arkeolojik ve yazılı belgelerin azlığı, bölgenin madencilik ve metal işlemeciliği sürecinin ana hatlarını ifade edilmesini güçleştirmiştir. Bu bölgenin bakır ve demir madeni yönünden zengin olduğunu bölgede yapılan kazılardan ziyade çeşitli buluntulardan anlamaktayız.
Bu çalışmada Kafkasya’nın maden ve metal işlemeciliğinin arkeolojik ve yazılı kanıtlar ışığında açıklanması amaçlanmıştır. Arkeolojik araştırmaların sonuçlarından hâreketle bölgede madenciliğin ve metal işlemeciliğinin başlangıcından itibaren nasıl bir gelişim süreci geçirdiği tespit edilmeye çalışılmıştır.
Pengembangan Bahan Ajar Berbasis E-Modul Interaktif Menggunakan Model Pembelajaran Berbasis Masalah Pada Materi Integral SMA Kelas XII
Authors: Salfia Elwi 
Published: August 2022

Penelitian ini bertujuan untuk mengembangkan bahan ajar matematika berbasis E-modul interaktif pada materi integral di SMA kelas XII serta mengetahui kelayakan bahan ajar E-modul interaktif sebagai sumber belajar yang dikembangkan di tinjau dari aspek materi, tampilan, dan pengoperasian berdasarkan penilaian para ahli. Sampel dalam penelitian ini ialah siswa kelas XII SMA Swasta Harapan Mekar yang berjumlah 10 orang. Penelitian ini menggunakan metode penelitian dan pengembangan ( Research and Development). Model pengembangan pada Penelitian ini menggunakan metode pengembangan perangkat pembelajaran model 4D. Instrumen penelitian yang digunakan yaitu Studi Pendauuan dan Validasi Ahli. Teknik analisis data yang digunakan yaitu analisis data kuantitatif dan kuaitatif. Hasil penelitian berupa bahan ajar berbasis e-modul interaktif pada materi integral yang layak digunakan. Kelayakan yang diperoleh dari validasi ahli materi dan ahli media adalah kategori layak digunakan dengan persentase penilaian materi 86,45% dan penilaian media 90,7% dengan kriteria baik sekali. Respon siswa terhadap bahan ajar yang diperoleh melalui uji coba kelompok kecil juga sangat baik dengan persentase 85,7%. Sehingga dapat disimpulkan bahwa bahan ajar berbasis e-modul interaktif pada materi integral SMA Kelas XII layak digunakan sebagai bahan ajar.
Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy: Guideline From the College of American Pathologists in Collaboration With the Association for Molecular Pathology and Fight Colorectal Cancer
Authors: Bartley Angela N. , Mills Anne M. , Konnick Eric , Overman Michael , Ventura Christina B. , Souter Lesley , Colasacco Carol , Stadler Zsofia K. , Kerr Sarah , Howitt Brooke E , Hampel Heather , Adams Sarah F. , Johnson Wenora , Magi-Galluzzi Cristina , Sepulveda Antonia R. , Broaddus Russell R. 
Published: August 2022

Context.—
The US Food and Drug Administration (FDA) approved immune checkpoint inhibitor therapy for patients with advanced solid tumors that have DNA mismatch repair defects or high levels of microsatellite instability; however, the FDA provided no guidance on which specific clinical assays should be used to determine mismatch repair status.

Objective.—
To develop an evidence-based guideline to identify the optimal clinical laboratory test to identify defects in DNA mismatch repair in patients with solid tumor malignancies who are being considered for immune checkpoint inhibitor therapy.

Design.—
The College of American Pathologists convened an expert panel to perform a systematic review of the literature and develop recommendations. Using the National Academy of Medicine–endorsed Grading of Recommendations Assessment, Development and Evaluation approach, the recommendations were derived from available evidence, strength of that evidence, open comment feedback, and expert panel consensus. Mismatch repair immunohistochemistry, microsatellite instability derived from both polymerase chain reaction and next-generation sequencing, and tumor mutation burden derived from large panel next-generation sequencing were within scope.

Results.—
Six recommendations and 3 good practice statements were developed. More evidence and evidence of higher quality were identified for colorectal cancer and other cancers of the gastrointestinal (GI) tract than for cancers arising outside the GI tract.

Conclusions.—
An optimal assay depends on cancer type. For most cancer types outside of the GI tract and the endometrium, there was insufficient published evidence to recommend a specific clinical assay. Absent published evidence, immunohistochemistry is an acceptable approach readily available in most clinical laboratories.
Keanekaragaman, komposisi spesies, dan kunci identifikasi lalat buah (Diptera: Tephritidae: Dacinae) di Pulau Lombok
Authors: Hudiwaku Syarron , Himawan Toto , Rizali Akhmad 
Published: July 2022

Informasi mengenai keanekaragaman lalat buah (Diptera: Tephritidae: Dacinae) di Pulau Lombok masih sangat terbatas. Penelitian ini bertujuan untuk mengetahui keanekaragaman, komposisi spesies, dan menyusun kunci identifikasi lalat buah di Pulau Lombok. Penelitian dilaksanakan di 6 lokasi, yaitu Taman Wisata Alam (TWA) Kerandangan, TWA Suranadi, hutan Lemor, kebun Gangga, Lingsar, dan Lemor yang tersebar di Pulau Lombok dari bulan Maret hingga Juni 2020. Setiap lokasi terdiri atas 6 plot pengamatan menggunakan metode transek sejauh satu kilometer dengan jarak antar plot 200 m. Lalat buah dikoleksi menggunakan perangkap tipe Steiner dengan atraktan yang berbeda, yaitu metil eugenol (ME) dan cue lure (CL). Identifikasi lalat buah dilakukan berdasarkan karakteristik morfologi di Laboratorium Karantina Tumbuhan, Balai Karantina Pertanian Kelas I Mataram. Hasil penelitian diperoleh 22 spesies dan 210.267 individu lalat buah dengan 4 spesies dominan, yaitu Bactrocera limbifera, B. caudata, B. carambolae, dan B. dorsalis. Spesies dengan kelimpahan tertinggi yang ditemukan adalah B. limbifera sebanyak 60.743 individu (29%) dan B. carambolae sebanyak 98.191 individu (47%). Berdasarkan 22 spesies yang diperoleh dibuat kunci identifikasi lalat buah di Pulau Lombok. Kunci identifikasi yang disusun berupa kunci dikotomi yang mendeskripsikan sebanyak 2 genus, 4 subgenus, dan 22 spesies. Penyusunan kunci identifikasi menggunakan matrik karakter morfologi, dengan membandingkan beberapa karakter morfologi kunci dalam menentukan spesies.
La investigación universitaria en formato podcast: análisis del proyecto Transmedia de la Universitat Jaume I de Castelló
Authors: Galán Cubillo Esteban , Sánchez Castillo Sebastián , Drylie Carey Lindsey 
Published: July 2022

La digitalización está transformando de forma radical la creación y el consumo del conocimiento. De entre los nuevos medios surgidos en las dos últimas décadas, uno de los que más éxito ha tenido en el ámbito científico es el podcast. Por ello, este trabajo plantea un análisis del podcast Transmedia antes de la pandemia COVID-19 en el periodo 2017-2020. Este podcast se encuentra alojado en el espacio Web comtransmedia.com y consiste en proyecto de comunicación científica en el que se busca construir un espacio de diálogo entre la comunidad académica y los profesionales de la comunicación para afrontar los múltiples retos que en el ámbito de la comunicación y las humanidades nos ha planteado el siglo XXI. La plataforma nació bajo el paraguas de la Universitat Jaume I de Castelló pero aglutina a investigadores y profesionales de distinos países, instituciones y diferentes niveles de experiencia. El proyecto Transmedia surgió en 2017 y ha publicado ya cerca de 600 contenidos fundamentalmente en formato sonoro y con el objetivo de dar a conocer los trabajos que se realizan desde los principales centros de investigación y ponerlos en diálogo con las iniciativas empresariales más innovadoras.
El artículo propone una metodología de investigación-acción como estrategia participativa que permite al equipo de investigación intervenir en el objeto de estudio para mejorar sus prácticas y se complementa con el análisis de las principales categorías a las que se adscriben los contenidos de la plataforma con el objetivo de evaluar las dimensiones transmedia del formato. Estas dimensiones ayudan a describir las diferentes categorías que se abordan en los contenidos y el nivel de respuesta que cada una tiene por parte de la audiencia.
Carta ao meu pai: em direção a uma consciência feminista
Authors: Pages Camargo Tamiê , Lino Netto Livian , Coelho da Silva Diônvera , Alves Guimarães Isabella , Farias Barrios Andressa , Rocha Clasen Julia , Veiga Júnior Álvaro , Accorssi Aline 
Published: August 2022

O artigo, construído em formato de carta, se inspira na realidade de muitas mulheres de nosso país. Aborda a experiência de abandono paterno de uma filha que, a partir do seu contato com teorias feministas, percebe e questiona as consequências da falta de paternagem ao longo de sua vida. Em busca da construção e da ampliação de uma consciência feminista, a carta apresenta um conjunto de reflexões direcionadas ao pai, morto recentemente vítima da COVID-19, e a outros homens. A reflexão perpassa às diferenças de classe, raça e gênero de forma interseccionada, aborda o cotidiano da reprodução da vida e ressalta a importância dos feminismos, enquanto posicionamento político, para a construção de relações mais igualitárias e justas. Conclui-se ressaltando, entre outros aspectos, a urgência de que homens assumam e compartilhem as responsabilidades no que se refere ao cuidado das crianças e do lar. Palavras-chave: paternagem, reprodução da vida; patriarcado; consciência feminista.
Influence of residential performance on residents' health status (part II): Nationwide survey of environmental performance of apartment buildings and residents' health status
Authors: Kawakubo Shun , Kamata Tomomitsu , Murakami Shuzo , Ikaga Toshiharu , Hoshi Tanji , Ando Shintaro 
Published: July 2022

AbstractThe residential environment clearly affects health. For example, a previous study has established relationships between specific environmental factors and the health status of residents in detached houses. However, studies focused on apartment buildings are still insufficient. Therefore, in this study, a large nationwide questionnaire survey of residents of apartments was conducted. The residential environment was subjectively evaluated using a Japanese Comprehensive Assessment System for Built Environment Efficiency (CASBEE) tool: the CASBEE Health Checklist. The results showed that residents living in apartments who score higher on the checklist tend to have a lower prevalence of various diseases, indicating that residential environment may be an important determinant of health. Furthermore, the odds ratios for residents living in apartment buildings were lower for diabetes mellitus, hypertensive diseases, heart diseases, cerebrovascular diseases, chronic lower respiratory diseases, and inflammatory polyarthropathies compared with residents living in detached houses. These findings support the general link between the residential environment and residents' health and suggest that housing typology is an important factor.
High‐Efficiency Blue Perovskite Light‐Emitting Diodes with Improved Photoluminescence Quantum Yield via Reducing Trap‐Induced Recombination and Exciton–Exciton Annihilation
Authors: Guan Zhiqiang , Li Yang , Zhu Zhaohua , Zeng Zixin , Chen Ziming , Ren Zhiwei , Li Gang , Tsang Sai‐Wing , Yip Hin‐Lap , Xiong Yuan , Lee Chun‐Sing 
Published: July 2022

AbstractAlthough the performance of blue perovskite LEDs (PeLEDs) has improved rapidly in the past few years, it still lags behind their green and red counterparts. One major cause of the inferior performance is the relatively low photoluminescence quantum yield (PLQY) of blue perovskite emitters due to more severe nonradiative recombination loss induced by traps and exciton–exciton annihilation (EEA). In this study, theoretical analysis reveals that trap‐induced recombination limits the maximum obtainable PLQY and EEA leads to fast roll‐off at high excitons densities. To address these issues, a synergic approach by introducing CsAc into perovskite and applying solvent annealing (SA) is used to suppress the trap‐induced recombination and the EEA, respectively. The acetate anion in CsAc effectively passivates defects of perovskite through Lewis acid–base reaction, enhancing PLQY of the perovskite films from 10.7% to 49.2%. Furthermore, carrier recombination dynamic investigations reveal that EEA and PLQY roll‐off are successfully deferred with SA treatment. As a result, external quantum efficiency (EQE) is improved from 2.9% to 11% and EQE roll‐off is significantly suppressed at high current density. This work demonstrates that alleviating trap‐induced and EEA non‐radiative losses are two effective methods to improve the PLQY and EQE of blue PeLEDs.
Sustained Release of Nitric Oxide and Cascade Generation of Reactive Nitrogen/Oxygen Species via an Injectable Hydrogel for Tumor Synergistic Therapy
Authors: Wang Yaoben , Yang Xiaowei , Chen Xiaobin , Wang Xin , Wang Yang , Wang Hancheng , Chen Zhiyong , Cao Dinglingge , Yu Lin , Ding Jiandong 
Published: July 2022

AbstractReactive nitrogen species (RNS) generated via the reaction of nitric oxide (NO) with reactive oxygen species (ROS) are more lethal than ROS, and thus RNS‐mediated therapy has great potential in cancer treatment, yet it is still largely unexploited. Herein, a novel, injectable and NO‐releasing hydrogel (NO‐Gel) composed of α‐(nitrate ester) acetic acid‐modified amphiphilic copolymers is developed. To further convert released NO to RNS, glutathione (GSH)‐sensitive CuCys nanoparticles (NPs) and β‐lapachone (Lapa) are co‐loaded into the NO‐Gel. This hydrogel system possesses a temperature‐induced sol‐gel transition and can continuously liberate Lapa, CuCys NPs, and NO in vitro for up to 3 weeks. The sustained supply of Lapa can efficiently boost hydrogen peroxide (H2O2) concentration in cancer cells, and intracellular GSH can induce the rapid release of NO and the reduction of CuCys NPs. With elevating H2O2 levels and producing highly reactive Cu(I), the Cu(I)‐catalyzed Fenton‐like reaction is dramatically enhanced, resulting in the generation of abundant hydroxyl radicals (·OH), and the subsequent cascade reactions among ·OH, H2O2, and NO cause more lethal RNS pool. After a single peritumoral injection of the hydrogel system, the cascade generation of ROS and RNS plus the substantial depletion of GSH can significantly suppress tumor growth.
Mass Transfer Printing of Metal‐Halide Perovskite Films and Nanostructures
Authors: Li Zhijian , Chu Shenglong , Zhang Yihan , Chen Wenjing , Chen Jia , Yuan Yongbo , Yang Shangfeng , Zhou Hongmin , Chen Tao , Xiao Zhengguo 
Published: July 2022

AbstractMost methods of depositing perovskite films cannot meet the diverse requirements of real applications such as depositing films on various types of substrates, making patterns with different bandgaps for full‐color display. Here, a robust mass transfer method of perovskite films and nanostructures is reported, meeting those requirements, by using an ultrathin branched polyethylenimine as interfacial chemical bonding layers. The transfer‐printed perovskite films exhibit comparable morphology, composition, optoelectronic properties, and device performances with the counterparts made by optimized spin‐coating methods. The perovskite light‐emitting diodes (PeLEDs) using the transfer‐printed films show decent external quantum efficiencies of 10.5% and 6.7% for red (680 nm) and sky‐blue (493 nm) emissions, which are similar to the devices made by spin‐coating. This robust transfer printing method also enables the the preparation of perovskite micropatterns with a high resolution up to 1270 pixels per inch. Horizontally aligned red and sky‐blue perovskite microstripes are further obtained through multiple printing processes for white PeLEDs. This work demonstrates a feasible strategy for making perovskite films or micropatterns on various substrates for real applications in full‐color display, white LEDs, lasing, etc.
Performance Improvement of Flexible Pressure Sensor Based on Ordered Hierarchical Structure Array
Authors: Yang Shaohua , Zhang Chengpeng , Ji Jin , Liu Yongzhi , Wang Jilai , Shi Zhenyu 
Published: July 2022

AbstractFlexible pressure sensors have been extensively explored for their widespread applications in wearable electronic devices such as medical diagnosis and motion monitoring. In this paper, a facile method is adopted to prepare the ordered hierarchical structure array and then it is applied to improve the performance of capacitive flexible pressure sensors. The results indicate that the pressure sensor based on hierarchical structure array is with high sensitivity (0.382 kPa‐1), fast response and recovery time (26 and 25 ms), and its minimum detection pressure can reach 4 Pa. Besides, the sensor based on hierarchical structure array has also been successfully applied to the dynamic pulse monitoring of the neck, limb movement monitoring, and pressure monitoring in water cup grasping process, which shows high stability and reliability, demonstrating its broad application prospects. This research could provide useful guidance for the preparation and applications of high‐performance flexible pressure sensors.
La2NiO4+δ‐Based Memristive Devices Integrated on Si‐Based Substrates
Authors: Khuu Thoai‐Khanh , Lefèvre Gauthier , Jiménez Carmen , Roussel Hervé , Riaz Adeel , Blonkowski Serge , Jalaguier Eric , Bsiesy Ahmad , Burriel Mónica 
Published: July 2022

AbstractValence change memories, in which internal redox reactions control the change in resistance are promising candidates for resistive random access memories (ReRAMs) and neuromorphic computing elements. In this context, La2NiO4+δ (L2NO4), a mixed ionic‐electronic conducting oxide, well known for its highly mobile oxygen interstitial ions, emerges as a potential switching material for novel L2NO4‐based memristive devices. However, their integration in complementary metal oxide semiconductor (CMOS) technology still has to be demonstrated, as the major focus of previous studies has been carried out on epitaxial films grown on single crystals. In this work, the optimization of the deposition temperature and precursor solution composition is presented, allowing to obtain high‐quality polycrystalline L2NO4 thin films grown by metal organic chemical vapor deposition on a platinized silicon substrate, and to use these films to build memristive devices in vertical configuration with Ti top electrodes. A bipolar analog‐type transition in resistance can be achieved in Ti/L2NO4/Pt memristive devices. While the “forming” process required for the devices based on nonoptimized L2NO4 thin films is considered as a drawback, the Ti/optimized L2NO4/Pt devices are forming‐free and exhibit a good cyclability. These results prove the switching response of L2NO4‐based devices in a vertical configuration for the first time.
Wind‐Driven Bidirectional Fluttering Triboelectric Nanogenerator Via Dual Flagpole and Slot Structure Design
Authors: Son Jin‐ho , Heo Deokjae , Goh Dongmin , Lee Minjoo , Chung Jihoon , Choi Seungtae , Lee Sangmin 
Published: July 2022

AbstractRecently, as fossil fuel reserves have decreased and energy requirements have increased worldwide, wind energy, which has various advantages, such as ubiquitous, sustainable, clean, and infinite energy capacitance, has attracted increasing attention. In particular, wind‐driven fluttering‐type triboelectric nanogenerators (TENGs), which can utilize mechanical movement induced by wind energy based on the coupling of the triboelectric effect and electrostatic induction, have been widely studied. However, previous studies have not discussed structural device designs to harvest bidirectional wind energy. Herein, a wind‐driven bidirectional fluttering triboelectric nanogenerator (WBF‐TENG) is reported, which has a dual flagpole and slot structure design to generate electrical output against wind blowing from both directions. Considering natural wind flow in random direction, WBF‐TENG is more effective compared with the previous unidirectional fluttering TENGs. The electrical output of the WBF‐TENG is quantitatively measured and analyzed in terms of the peak and root mean square outputs depending on various design parameters and wind velocities. The findings demonstrated that the WBF‐TENG can be utilized as a swing safety light by continuously turning on 76 LEDs when riding a swing during right and left direction movements. Furthermore, the WBF‐TENG can scavenge omnidirectional wind energy by vertically stacking two devices.
Harvesting Wide Frequency Micromechanical Vibration Energy and Wind Energy with a Multi‐Mode Triboelectric Nanogenerator for Traffic Monitoring and Warning
Authors: Yang Chunchun , Liu Guanlin , Wang Xuejiao , Liu Boxun , Xiao Longfa , Wan Lingyu , Yao Huilu 
Published: July 2022

AbstractWith the rapid development of road networks, various traffic safety issues have become endless. To solve the problems, a multi‐mode triboelectric nanogenerator(M‐TENG) composed of roller‐based TENG, turnplate‐based TENG, and vertical separation‐based TENG is proposed. The M‐TENG can be applied to harvest the wind energy and mechanical vibrational energy generated by moving vehicles on ordinary roads or roads beside bridges to provide power for traffic warning devices and signal sensors. In terms of wind energy harvesting, the M‐TENG shows an excellent wind energy conversion capability. For vibrational energy harvesting, the M‐TENG can respond well to the frequency range (1–40 Hz) of bridge vibration in an actual environment and produce a good output. Thus, due to the above excellent outputs, the M‐TENG can successfully power caution lights and commercial LED strips, achieving a good warning effect. Additionally, the M‐TENG also can send RF signals after charging the energy management unit circuit for 5 min when simulating a natural environment. Based on the aforementioned wide applications, the M‐TENG not only demonstrates its excellent energy harvesting capability but also shows that it has huge potential in the field of transportation.