bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningkatkan Kemampuan Motorik Halus melalui Kegiatan Finger Painting Menggunakan Pasta Ajaib Pelangi
Authors: Arum Sekar Sari Wuni , Aprilina Nisa Fitri Novida 
Published: November 2022

Penelitian ini mempunyai tujuan untuk meningkatkan kemampuan motorik halus anak melalui kegiatan finger painting menggunakan pasta ajaib pelangi di kelompok B Taman Kanak-kanak Dharma Wanita 1 Babadan Ngancar Kabupaten Kediri Tahun Pelajaran 2021/2022. Kegiatan finger painting menggunakan pasta ajaib pelangi ini dapat menarik minat anak guna meningkatkan kemampuan motorik halus anak. Upaya meningkatkan kemampuan motorik halus pada kegiatan finger painting ini menekankan pada penyelarasan antara mata dengan otot tangan anak serta kelenturan jari jemari anak. Sebagai subjek dalam penelitian ini yaitu anak kelompok B TK Dharma Wanita 1 Babadan dengan jumlah 15 anak, terdiri dari 5 anak laki-laki dan 10 anak perempuan. Peneliti telah mengadakan perbaikan pembeljaran yang dilaksanakan selama 5 hari pada siklus I dan dilanjutkan dengan 5 hari pada siklus II mengingat kemampuan motorik halus anak belum mencapai tingkat ketuntasan yang ditargetkan. Bersumber pada analisis data maka kami simpulkan bahwa aktivitas finger painting dengan menggunakan pasta ajaib pelangi bisa tingkatkan kemampuan motorik halus pada anak kelompok B TK Dharma Wanita I Babadan Kecamatan Ngancar Kabupaten Kediri Tahun Pelajaran 2021/ 2022.

Abstract
This study aims to improve children's fine motor skills through finger painting activities using rainbow magic paste in group B of Dharma Wanita Kindergarten 1 Babadan Ngancar, Kediri Regency, Academic Year 2021/2022. Finger painting activities using rainbow magic paste can attract children's interest in order to improve children's fine motor skills. Efforts to improve fine motor skills in this finger painting activity emphasize the coordination of hand muscles and the flexibility of children's fingers. As subjects in this study, group B of Dharma Wanita 1 Babadan Kindergarten consisted of 15 children, consisting of 5 boys and 10 girls. Researchers have carried out learning improvements which are carried out for 5 days in cycle I and continued with 5 days in cycle II considering that children's fine motor abilities have not reached the targeted level of completeness. Based on data analysis, we conclude that finger painting activities using rainbow magic paste can improve fine motor skills in group B children of Dharma Wanita I Babadan Kindergarten, Ngancar District, Kediri Regency, Academic Year 2021/2022.
PEMBERDAYAAN KELOMPOK NELAYAN MELALUI PROGRAM SENTRA KELAUTAN DAN PERIKANAN TERPADU DI DESA DALUM KECAMATAN SALIBABU KABUPATEN KEPULAUAN TALAUD
Authors: Prihatini Juliati , Elungan Preisy Celin , Rifai M. 
Published: November 2022

Dalum Village is one of the villages in the Talaud Islands Regency with its residents mostly living as fishermen, however, fishermen in Dalum Village are fishermen who are not fully empowered or have not been developed even though the government through the Fisheries Service of the Talaud Islands Regency has empowered fishermen groups in Dalum Village through the Integrated Marine and Fisheries Center Program. This study aims to describe and analyze the empowerment of fishermen groups through the Integrated Marine and Fisheries Center Program, inhibiting factors and supporting factors for the implementation of empowerment and efforts made in overcoming inhibiting factors. The design of this study is descriptive qualitative with an inductive approach. Data collection techniques are carried out through interviews, observations and documentation. Data analysis techniques are carried out by data reduction, data presentation and drawing conclusions. The results showed that the Empowerment of Fishermen Groups through the Integrated Marine and Fisheries Center Program in Dalum Village, Salibabu District, Talaud Islands Regency, Fishermen Group Study at the Teluk Lawasan Indah Cooperative conducted by the Fisheries Service of the Talaud Islands Regency was carried out with four indicators, namely human development, business development, environmental development and institutional development. Through these four indicators, the empowerment process has been running, but there are still many shortcomings that are obstacles in the implementation of empowerment such as: the low level of education of fishermen groups related to the technology used, the facilities and infrastructure used by fishermen groups are still simple, the dependence of fishermen groups on assistance provided by the government, and the lack of sufficient availability of electricity in the Island Regency area Talaud.
Keywords: Fishing Group, Empowerment, Integrated Marine and Fisheries Center Program
Modified spectral conjugate gradient iterative scheme for unconstrained optimization problems with application on COVID-19 model
Authors: Novkaniza Fevi , Malik Maulana , Sulaiman Ibrahim Mohammed , Aldila Dipo 
Published: November 2022

In this work, a new class of spectral conjugate gradient (CG) method is proposed for solving unconstrained optimization models. The search direction of the new method uses the ZPRP and JYJLL CG coefficients. The search direction satisfies the descent condition independent of the line search. The global convergence properties of the proposed method under the strong Wolfe line search are proved with some certain assumptions. Based on some test functions, numerical experiments are presented to show the proposed method's efficiency compared with other existing methods. The application of the proposed method for solving regression models of COVID-19 is provided.Mathematics subject classification65K10, 90C52, 90C26.
Characterization of carotenoids in Lycium barbarum fruit by using UPC2-PDA-Q-TOF-MSE couple with deep eutectic solvents extraction and evaluation of their 5α-reductase inhibitory activity
Authors: Yu Zhonglian , Xia Mengqin , Li Xueping , Wang Rui , Liu Wenjing , Zheng Ruirong , Wang Zhengtao , Yang Li , Shi Yanhong 
Published: November 2022

Carotenoids from Lycium barbarum fruits have possessed pharmacological efficacy against eye diseases, cardiovascular disorders, cancer, and benign prostatic hyperplasia. However, the efficient extraction, rapid characterization and activities evaluation of Lycium carotenoids remains a challenge. To concentrate and characterize Lycium carotenoids, we have developed ultrasound-assisted extraction methods with different deep eutectic solvents (DESs) and analyzed carotenoids by ultra-performance convergence chromatography coupled with photo diode array detector and quadrupole time-of-flight mass spectrometry (UPC2-PDA-Q-TOF-MSE). DESs containing choline chloride and malonic acid presented better extraction efficiency and were more environmentally friendly than other extraction methods. Carotenoids were more quickly profiled (in 11 min) by UPC2 compared to by UPLC (in 35 min), with seventeen main peaks were characterized in the MS fragmentation patterns. The in vitro 5α-reductase inhibitory activity of DESs extracts, fractions and components were subsequently assessed, and the predominant component zeaxanthin dipalmitate (ZD) exhibited potent inhibitory activity. Our study provides a chemical and pharmacological basis for the further development of potential new drugs based on Lycium carotenoids.
Association of acetaldehyde dehydrogenase 2 rs671 polymorphism with the occurrence and progression of atrial fibrillation
Authors: Ge Junye , Han Wenqiang , Ma Chuanzhen , Chen Tongshuai , Liu Huiyu , Maduray Kellina , Qu Yinan , Li Yihan , Hu Tong , Wang Qinhong , Zhong Jingquan 
Published: November 2022

BackgroundAcetaldehyde dehydrogenase 2 (ALDH2) is an essential enzyme in alcohol metabolism, playing a vital function in resisting oxidative stress. Lots of gene variants have been associated with atrial fibrillation (AF), among which the association between ALDH2 rs671 polymorphism and AF is variable. This study aimed to investigate the relationship between ALDH2 rs671 polymorphism and AF occurrence or progression and AF recurrence after catheter ablation.MethodsA total of 924 subjects were enrolled in the study. The ALDH2 genotypes are composed of wild-type homozygotes (ALDH2*1/*1), heterozygotes (ALDH2*1/*2), and mutant homozygotes (ALDH2*2/*2), in which the genotypes ALDH2*1/*2 and ALDH2*2/*2 are combined into the ALDH2*2. Univariate and multivariate logistic regression analyses were performed to investigate the association between ALDH2*2 and AF occurrence and progression. COX regression analysis was used to explore the association of ALDH2*2 with AF recurrence after catheter ablation.ResultsThe prevalence of AF differed significantly between the ALDH2*2 group (102/251) and ALDH2*1/*1 group (330/673) (P = 0.023). For AF occurrence, in the univariate analysis, alcohol consumption was a risk factors (OR: 1.503, P = 0.003), whereas ALDH2*2 was a protective factor (OR: 0.712, P = 0.023). In the multivariate analysis, alcohol consumption (P = 0.156) and ALDH2*2 (P = 0.096) were no longer independent factors. ALDH2*2 with non-drinking was associated with a decreased AF occurrence (OR: 0.65, P = 0.021), whereas ALDH2*2 with drinking was not (P = 0.365). For AF progression, multivariate analysis revealed ALDH2*2 could promote persistent AF in female AF patients (OR: 2.643, P = 0.008). Cox regression analysis suggested that ALDH2*2 (P = 0.752) was not a risk factor for AF recurrence after catheter ablation during a median 6 months follow-up.ConclusionWhile ALDH2*2 was not directly related to AF, ALDH2*2 with non-drinking was associated with a decreased incidence of AF. ALDH2*2 may accelerate AF progression in female patients, increasing the likelihood of developing persistent AF. Therefore, individuals with ALDH2*2 should refrain from consuming alcohol to decrease the onset and progression of AF.
Association between SEMA3A signaling pathway genes and BMD/OP risk: An epidemiological and experimental study
Authors: Zhou Hao-long , Wei Mu-hong , Di Dong-sheng , Zhang Ru-yi , Zhang Jian-li , Yuan Ting-ting , Liu Qian , Zhou Ting-ting , Huang Qin , Wang Qi 
Published: November 2022

ObjectiveThis study aimed to explore the associations of genetic variants in the semaphorin 3A (SEMA3A) signaling pathway genes, including SEMA3A, NRP1, PLXNA1, PLXNA2 and PLXNA3 with osteoporosis (OP) risk and bone mineral density (BMD) in a Chinese Han older adult population.Study design and methodA two-stage design was adopted. Total of 47.8kb regions in the 5 genes were sequenced using targeted next-generation sequencing (NGS) technology in the discovery stage, and the discovered OP-related single nucleotide polymorphisms (SNPs) were further genotyped using improved multiple linkage detection reaction technique in the validation stage. Methods of ALP/TRAP staining, real-time fluorescent quantitative PCR, and cell proliferation and apoptosis assays were performed with MC3T3-E1 and RAW 264.7 cell lines to clarify biological effects of observed functional variants in cell lines responsible for bone mass remodeling.ResultsTotal of 400 postmenopausal women (211 OP cases) were involved in the discovery stage, where 6 common and 4 rare genetic variants were found to be associated with OP risk. In the validation stage among another 859 participants (417 women, 270 OP cases), the PLXNA2 rs2274446 T allele was associated with reduced OP risk and increased femoral neck (FN) BMD compared to the C allele. Moreover, significant associations of NRP1 rs2070296 with FN BMD/OP risk and of NRP1 rs180868035 with lumbar spine and FN BMDs were also observed in the combination dataset analysis. Compared to the osteoblasts/osteoclasts transfected with the wild-type NRP1 rs180868035, those transfected with the mutant-type had reduced mRNA expression of osteoblastic genes (i.e., ALP, RUNX2, SP7 and OCN), while elevated mRNA expression of osteoclastic genes (i.e., TRAP, NFATc1 and CTSK). Furthermore, mutant NRP1 rs180868035 transfection inhibited osteoblast proliferation and osteoclast apoptosis, while promoted osteoclast proliferation and osteoblast apoptosis in corresponding cell lines.ConclusionGenetic variants located in NRP1 and PLXNA2 genes were associated with OP risk and BMD. The NRP1 rs180868035 affects bone metabolism by influencing osteoblasts and osteoclasts differentiation, proliferation and apoptosis.
The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort
Authors: Ivell Richard , Heng Kee , Severn Katie , Antonio Leen , Bartfai Gyorgy , Casanueva Felipe F. , Huhtaniemi Ilpo T. , Giwercman Aleksander , Maggi Mario , O’Connor Daryl B. , O’Neill Terence W. , Punab Margus , Rastrelli Giulia , Slowikowska-Hilczer Jolanta , Tournoy Jos , Vanderschueren Dirk , Wu Frederick C. W. , Anand-Ivell Ravinder 
Published: November 2022

BackgroundInsulin-like peptide 3 (INSL3) is a constitutive hormone secreted in men by the mature Leydig cells of the testes. It is an accurate biomarker for Leydig cell functional capacity, reflecting their total cell number and differentiation status.ObjectivesTo determine the ability of INSL3 to predict hypogonadism and age-related morbidity using the EMAS cohort of older community-dwelling men.Materials &amp; methodsCirculating INSL3 was assessed in the EMAS cohort and its cross-sectional and longitudinal relationships to hypogonadism, here defined by testosterone (T) &lt;10.5nmol/l, and a range of age-related morbidities determined by correlation and regression analysis.Results &amp; discussionWhile INSL3 is an accurate measure of primary hypogonadism, secondary and compensated hypogonadism also indicate reduced levels of INSL3, implying that testicular hypogonadism does not improve even when LH levels are increased, and that ageing-related hypogonadism may combine both primary and secondary features. Unadjusted, serum INSL3, like calculated free testosterone (cFT), LH, or the T/LH ratio reflects hypogonadal status and is associated with reduced sexual function, bone mineral density, and physical activity, as well as increased occurrence of hypertension, cardiovascular disease, cancer, and diabetes. Using multiple regression analysis to adjust for a range of hormonal, anthropometric, and lifestyle factors, this relationship is lost for all morbidities, except for reduced bone mineral density, implying that INSL3 and/or its specific receptor, RXFP2, may be causally involved in promoting healthy bone metabolism. Elevated INSL3 also associates with hypertension and cardiovascular disease. When unadjusted, INSL3 in phase 1 of the EMAS study was assessed for its association with morbidity in phase 2 (mean 4.3 years later); INSL3 significantly predicts 7 out of 9 morbidity categories, behaving as well as cFT in this regard. In contrast, total T was predictive in only 3 of the 9 categories.ConclusionTogether with its low within-individual variance, these findings suggest that assessing INSL3 in men could offer important insight into the later development of disease in the elderly.
Predicting peak day and peak hour of electricity demand with ensemble machine learning
Authors: Fu Tao , Zhou Huifen , Ma Xu , Hou Z. Jason , Wu Di 
Published: November 2022

Battery energy storage systems can be used for peak demand reduction in power systems, leading to significant economic benefits. Two practical challenges are 1) accurately determining the peak load days and hours and 2) quantifying and reducing uncertainties associated with the forecast in probabilistic risk measures for dispatch decision-making. In this study, we develop a supervised machine learning approach to generate 1) the probability of the next operation day containing the peak hour of the month and 2) the probability of an hour to be the peak hour of the day. Guidance is provided on preparation and augmentation of data as well as selection of machine learning models and decision-making thresholds. The proposed approach is applied to the Duke Energy Progress system and successfully captures 69 peak days out of 72 testing months with a 3% exceedance probability threshold. On 90% of the peak days, the actual peak hour is among the 2 h with the highest probabilities.
Evaluating resource utilization efficiency in urban land construction of Yangtze river economic zone under technological progress
Authors: Wei Wei , Qian Xiaoyan , Lin Qing , Zheng Qiongjie , Cao Yu , Chen Xiding 
Published: November 2022

Based on the economic models of DEA-Malmquist, this paper estimated the land utilization efficiency by considering dimensions such as energy, water and economic inputs in the Yangtze River Delta urban agglomeration from 2004 to 2016, and analyzed its spatial and temporal evolution pattern and characteristics. Then use the Tobit model to explore the main influencing factors, and examine the contribution of each influencing factor, such as technical progress. The research results show that the urban construction efficiency and the distance from the port have a “∽” curve relationship, verifying the “center-periphery” theory of new economic geography. It is also found that the effective radiation distance of the current economic center Shanghai to the surrounding area is 361.5 km. The structural analysis of the efficiency of construction land shows that the market mechanism has not played a fundamental role in the allocation of construction land resources, the improvement of the quality of labor force, and the expansion of capital clustering with industry is the main driving factor to support the efficiency of construction land use in the Yangtze River Delta region. We suggest that more efforts will be needed to reform market mechanisms and improve technological progress in the near future.
Study on multidimensional changes of rainfall erosivity during 1970–2017 in the North–South Transition Zone, China
Authors: Li Li , Zhu Wenbo , Liu Junjie , Zhang Li , Zhu Lianqi , Wang Liyuan , Chen Chaonan , Ahmed Naveed , Gurung Sher Bahadur 
Published: November 2022

China is one of the world’s most seriously affected regions by water and soil erosion. Soil erosion is a major cause and an important component of land degradation, which has a negative impact on ecological protection and sustainable socioeconomic development. Rainfall erosivity (RE) is one of the key parameters to assess the degree of soil erosion. Quantifying the content of RE and the formation mechanism is important to accurately measure the degree of soil erosion and provide a theoretical basis for soil erosion management. Here, this study analyzed the spatial and temporal characteristics of RE and their driving mechanisms in the Qinba Mountains from 1970 to 2017 using a daily rainfall model. Furthermore, geographical detector methods were used to quantitatively identify the dominant factors affecting RE and the dominant factors affecting RE on different topographic reliefs. The results showed that the RE between 1970 and 2017 averaged 4,197.85 MJ mm hm−2 h−1 a−1, with a mutation coefficient of 0.16. The spatial distribution of RE is high in the southeast and low in the northwest, and the mean annual RE declines with the increase in latitude in longitude and increases with the reduction in longitude in latitude. In addition, precipitation and temperature are the main factors affecting the spatial distribution of RE. Among these, precipitation can explain about 97% of the RE and temperature can explain about 65% of the RE. These findings should be essential for managing soil and water loss in the North–South Transition Zone, China.
Simulation of citrus production space based on MaxEnt
Authors: Lin Zhengyu , Chen Chunyan , Liu Yuanli , Liu Guanghui , He Peng , Liao Guitang , Gao Wenbo , Cao Ji , Shao Zhouling 
Published: November 2022

Crop production space is the most important part of land use system, and spatial simulation has always been the key task of land science. Crop production space is affected by many factors on different spatio-temporal scales, which leads to the complexity of simulation models. The existing simulation models also have the limitations of lack of human factors, large simulation area and excessive reliance on expert experience. Sichuan Province is a typical area of Citrus spatial expansion in China, so it is of great practical significance to carry out spatial regulation. From the comprehensive perspective of nature and humanity, this research uses MaxEnt, ArcGIS, Orcale, SQL to design a spatial regulation method (CSSM) for citrus, predict the citrus production space in Sichuan Province in 2025, and put forward regulation suggestions. The results showed that the citrus spatial simulation method better reflects the comprehensive effect of natural and human factors on crop space, and realizes the research on the regulation of single crop production space. The dominant environmental variables affecting citrus production in Sichuan are input of production factors, society, climate and terrain. Human activities play a leading role. The suitable environment for citrus production in Sichuan is: elevation ≤500m, annual average temperature ≥16.5 °C, aspect are northeast, southwest and northwest, supported by preferential policies, the input of Citrus fertilizer in the county is ≥ 500t, the input of Citrus labor in the county is ≥ 5,000, the input of Citrus pesticide in the county is ≥ 12.5t, and the technical progress represented by unit yield is 750–7000 t/km2. The suitable space for citrus production in Sichuan are mainly located in Zigong, Nanchong, Ziyang, Neijiang, Meishan, Leshan, Yibin and Luzhou. The government should choose a positive low growth scenario to stabilize the citrus area in Sichuan at 3533 km2 in 2025, and form a major citrus production area in Meishan, Ziyang, Neijiang, Chengdu, Nanchong and Yibin.
Structure and evolution of the squamate major histocompatibility complex as revealed by two Anolis lizard genomes
Authors: Card Daren C. , Van Camp Andrew G. , Santonastaso Trenten , Jensen-Seaman Michael I. , Anthony Nicola M. , Edwards Scott V. 
Published: November 2022

The major histocompatibility complex (MHC) is an important genomic region for adaptive immunity and has long been studied in ecological and evolutionary contexts, such as disease resistance and mate and kin selection. The MHC has been investigated extensively in mammals and birds but far less so in squamate reptiles, the third major radiation of amniotes. We localized the core MHC genomic region in two squamate species, the green anole (Anolis carolinensis) and brown anole (A. sagrei), and provide the first detailed characterization of the squamate MHC, including the presence and ordering of known MHC genes in these species and comparative assessments of genomic structure and composition in MHC regions. We find that the Anolis MHC, located on chromosome 2 in both species, contains homologs of many previously-identified mammalian MHC genes in a single core MHC region. The repetitive element composition in anole MHC regions was similar to those observed in mammals but had important distinctions, such as higher proportions of DNA transposons. Moreover, longer introns and intergenic regions result in a much larger squamate MHC region (11.7 Mb and 24.6 Mb in the green and brown anole, respectively). Evolutionary analyses of MHC homologs of anoles and other representative amniotes uncovered generally monophyletic relationships between species-specific homologs and a loss of the peptide-binding domain exon 2 in one of two mhc2β gene homologs of each anole species. Signals of diversifying selection in each anole species was evident across codons of mhc1, many of which appear functionally relevant given known structures of this protein from the green anole, chicken, and human. Altogether, our investigation fills a major gap in understanding of amniote MHC diversity and evolution and provides an important foundation for future squamate-specific or vertebrate-wide investigations of the MHC.