bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings
Authors: Chen Kellen , Sivaraj Dharshan , Davitt Michael F. , Leeolou Melissa C. , Henn Dominic , Steele Sydney R. , Huskins Savana L. , Trotsyuk Artem A. , Kussie Hudson C. , Greco Autumn H. , Padmanabhan Jagannath , Perrault David P. , Zamaleeva Alsu I. , Longaker Michael T. , Gurtner Geoffrey C. 
Published: April 2022

AbstractBiological scaffolds such as hydrogels provide an ideal, physio‐mimetic of native extracellular matrix (ECM) that can improve wound healing outcomes after cutaneous injury. While most studies have focused on the benefits of hydrogels in accelerating wound healing, there are minimal data directly comparing different hydrogel material compositions. In this study, we utilized a splinted excisional wound model that recapitulates human‐like wound healing in mice and treated wounds with three different collagen hydrogel dressings. We assessed the feasibility of applying each dressing and performed histologic and histopathologic analysis on the explanted scar tissues to assess variations in collagen architecture and alignment, as well as the tissue response. Our data indicate that the material properties of hydrogel dressings can significantly influence healing time, cellular response, and resulting architecture of healed scars. Specifically, our pullulan‐collagen hydrogel dressing accelerated wound closure and promoted healed tissue with less dense, more randomly aligned, and shorter collagen fibres. Further understanding of how hydrogel properties affect the healing and resulting scar architecture of wounds may lead to novel insights and further optimization of the material properties of wound dressings.
THE WHOLENESS OF HUMANITY: COLERIDGE, COGNITION, AND HOLISTIC PERCEPTION
Authors: Wallace Rebekah 
Published: April 2022

AbstractHolistic perception is an antidote to the subject–object divide, a divide that leads to a mechanistic understanding of the world and can see human beings only in terms of parts, without a robust articulation of wholeness. In this piece, I argue that philosopher of science Henri Bortoft offers an empirically grounded theory, based on consciousness studies, which recasts the problem of the many and the one, offering insight into just such a holistic perception. I further argue that Samuel Taylor Coleridge's philosophy of unity and multiplicity agrees in many respects with that of Bortoft. However, Coleridge draws further implications of his philosophy for Trinitarian theology. I will argue, in line with Bortoft and Coleridge, that perception is a hinge point in this discussion, allowing the move between the discussion of wholeness, subjectivity, and identity. I conclude that a holistic perceptual shift reconstitutes the human person in a way that is theologically significant, especially with respect to Christian Trinitarian doctrine.
Retinal nerve fibre layer thickness measured with SD-OCT in a population-based study: the Handan Eye Study
Authors: Wu Jian , Du Yifan , Lin Caixia , Zhu Yingting , Chen Wei , Pan Qing , Zhuo Yehong , Wang Ningli 
Published: April 2022

PurposeTo examine the normative profile of retinal nerve fibre layer (RNFL) thickness and ocular parameters based on spectral-domain optical coherence tomography (SD-OCT) and its associations with related parameters among the Chinese population.MethodsThis population-based cohort Handan Eye Study (HES) recruited participants aged≥30 years. All subjects underwent a standardised ophthalmic examination. Peripapillary RNFL thickness was obtained using SD-OCT. Mixed linear models were adopted to evaluate the correlation of RNFL thickness with ocular parameters as well as systemic factors. R V.3.6.1 software was used for statistical analysis.Results3509 subjects (7024 eyes) with the average age of 55.54±10.37 were collected in this analysis. Overall mean RNFL thickness measured was 113.46±10.90 µm, and the thickest quadrant of parapapillary RNFL was the inferior quadrant, followed by the superior quadrant, the nasal quadrant and the temporal quadrant. In the multivariate linear regression model, thinner RNFL thickness was remarkable association with male (p<0.001), older age (p<0.001), increased body mass index (>30, p=0.018), absence of diabetes (p=0.009), history of cataract surgery (p=0.001), higher intraocular pressure (p=0.007), lower spherical equivalent (p<0.001) and increased axial length (p=0.048).ConclusionsIn non-glaucoma individuals, this difference of RNFL thickness in Chinese population should be noted in making disease diagnoses. Meanwhile, multiple ocular and systemic factors are closely related to the thickness of RNFL. Our findings further emphasise the need to demonstrate ethnic differences in RNFL thickness and the specificity of associated ocular and systemic factors, as well as to develop better normative databases worldwide.Trial registration numberHES was registered in Chinese Clinical Trial Registry website, and the registry number was ChiCTR-EOC-17013214.
Impact of the COVID-19 lockdown on psychological health and nutritional habits in Italy: results from the #PRESTOinsieme study
Authors: Lorenzoni Giulia , Azzolina Danila , Maresio Elisabetta , Gallipoli Silvia , Ghidina Marco , Baldas Solidea , Berchialla Paola , Giron Maria Cecilia , Silano Marco , Gregori Dario 
Published: April 2022

ObjectivesThe present work aims to present the results of the ‘PRESTOinsieme’ (which is ‘we will be together soon’ in English). The web-based survey (www.prestoinsieme.com) describes changes in lifestyle habits and symptoms of psychological discomfort in the Italian population during the COVID-19 lockdown.DesignCross-sectional online survey disseminated by messaging apps (ie, WhatsApp and Telegram) and social networks (ie, Instagram, Facebook and LinkedIn).SettingItaly.ParticipantsItalian population older than 16 years of age.ExposureCOVID-19 lockdown.Main outcomes and measuresSurvey respondents filled out a set of validated questionnaires aimed at assessing lifestyle habits and psychological health, that is, the General Health Questionnaire (GHQ-12) to screen for psychological distress, the Impact of Event Scale-Revised (IES-R) to screen for post-traumatic stress and the Center for Epidemiologic Studies Depression Scale (CES-D).ResultsSurvey respondents totalled 5008. Moderate or severe psychological distress was reported in 25.5% and 22% of survey respondents, respectively. Lower age, female gender, being unemployed (OR 1.57, 95% CI 1.22 to 2.02) or being a student (OR 1.73, 95% CI 1.31 to 2.28) were predictors of more severe depressive symptoms.ConclusionsThe present study is one of the largest population-based surveys conducted in Italy during the first COVID-19 lockdown, providing valuable data about the Italian population’s psychological health. Further studies should be conducted to understand whether psychological distress persists after the end of the lockdown.
Qualitative study informing the development and content validity of the HAND-Q: a modular patient-reported outcome measure for hand conditions
Authors: Sierakowski Kyra , Kaur Manraj N , Sanchez Kathleen , Bain Gregory , Cano Stefan J , Griffin Philip , Klassen Anne , Pusic Andrea L , Lalonde Don , Dean Nicola R 
Published: April 2022

ObjectivesThe purpose of this study was to identify and understand the issues that are relevant to patients with hand conditions. The data were used to develop a patient-reported outcome measure (PROM) for adults with hand conditions (HAND-Q) and refine it with input from patients and clinician experts.DesignSemistructured qualitative interviews were used to understand what matters to patients. Cognitive debriefing was used to refine preliminary HAND-Q scales.SettingHand clinics in tertiary healthcare centres in Canada, Australia and USA.ParticipantsEligible participants were English-speaking adults who had experienced hand surgery in the preceding 12 months and were at least 4 weeks post-hand surgery A total of 62 in-depth interviews (females, n=34; mean age=65 years) were conducted to develop an item pool and draft the HAND-Q scales. The preliminary scales were refined through cognitive debriefing interviews with 20 participants and feedback from 25 clinician experts. All interviews were audiorecorded, transcribed verbatim and coded using a line-by-line approach.ResultsQualitative data were organised into two top-level domains of health-related quality of life and satisfaction with treatment outcomes. The scales were refined iteratively, and the field-test version included 319 unique items and 20 independently functioning scales.ConclusionsThe HAND-Q is a comprehensive PROM developed using extensive patient and clinician expert input, following established guidelines for PROM development and validation. In the next phase, the psychometric properties of the HAND-Q will be established in an international field test, following which the HAND-Q will be available for use in clinical research and practice .
Understanding surgical disease and care for Māori in Aotearoa: protocol for a scoping review
Authors: Rahiri Jamie-Lee , Tuhoe Jason , Harwood Matire , Koea Jonathan 
Published: April 2022

IntroductionMāori continue to experience inequitable healthcare and health outcomes compared with other New Zealanders. A narrative review conducted in 2016 described disparities in access to and through the surgical care pathway for Māori from a limited pool of small retrospective cohort studies. This review only targeted studies that specifically investigated surgical care for Māori; however, many other studies have performed subanalyses for Māori as part of bigger ethnographic epidemiological studies and Indigenous health has become more topical in Australasia since this review was conducted. Health disparities and inequities in surgical care for Māori are still not well understood. This scoping review aims to report the nature and extent of disparities in surgical disease and care for Māori.Methods and analysisA scoping review will be performed in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews Checklist. This study will be informed by Kaupapa Māori research methodology. Electronic searches of PubMed, MEDLINE, Embase and Cumulative Index to Nursing and Allied Health Literature Plus will be performed between 19 February and 19 March 2022. Two authors will independently identify and retrieve relevant texts in an iterative manner and examine how responsive each of the included studies are to Māori using the recently described Māori framework—a framework designed to guide researcher responsiveness to Māori.Ethics and disseminationEthical approval has not been sought as our review will only include published and publicly accessible data. We will publish the review in an open access peer-reviewed surgical journal. This protocol has been registered in Open Science Framework (10.17605/OSF.IO/NP4H3).
Understanding national trends in COVID-19 vaccine hesitancy in Canada: results from five sequential cross-sectional representative surveys spanning April 2020–March 2021
Authors: Lavoie Kim , Gosselin-Boucher Vincent , Stojanovic Jovana , Gupta Samir , Gagné Myriam , Joyal-Desmarais Keven , Séguin Katherine , Gorin Sherri Sheinfeld , Ribeiro Paula , Voisard Brigitte , Vallis Michael , Corace Kimberly , Presseau Justin , Bacon Simon 
Published: April 2022

ObjectiveTo examine rates of vaccine hesitancy and their correlates among Canadian adults between April 2020 and March 2021.DesignFive sequential cross-sectional age, sex and province-weighted population-based samples who completed online surveys.SettingCanada.ParticipantsA total of 15 019 Canadians aged 18 years and over were recruited through a recognised polling firm (Leger Opinion). Respondents were 51.5% female with a mean age of 48.1 (SD 17.2) years (range 18–95 years) and predominantly white (80.8%).Primary and secondary outcome measuresRates of vaccine hesitancy over the five surveys (time points) and their sociodemographic, clinical and psychological correlates.ResultsA total of 42.2% of respondents reported some degree of vaccine hesitancy, which was lowest during surveys 1 (April 2020) and 5 (March 2021) and highest during survey 3 (November 2020). Fully adjusted multivariate logistic regression analyses revealed that women, those aged 50 and younger, non-white, those with high school education or less, and those with annual household incomes below the poverty line in Canada were significantly more likely to report vaccine hesitancy, as were essential and healthcare workers, parents of children under the age of 18 and those who do not get regular influenza vaccines. Endorsing prevention behaviours as important for reducing virus transmission and high COVID-19 health concerns were associated with 77% and 54% reduction in vaccine hesitancy, respectively. Having high personal financial concerns was associated with 1.33 times increased odds of vaccine hesitancy.ConclusionsResults highlight the importance of targeting vaccine efforts to specific groups by emphasising the outsized health benefits compared with risks of vaccination. Future research should monitor changes in vaccine intentions and behaviour to better understand underlying factors.
Latent class growth analysis identified different trajectories in cognitive development of extremely low birthweight children
Authors: Haavisto Anu , Klenberg Liisa , Tommiska Viena , Lano Aulikki , Mikkola Kaija , Fellman Vineta 
Published: April 2022

BackgroundRecent longitudinal studies suggest stable cognitive development in preterm children, although with great individual variation. This prospective neurocognitive follow-up study of extremely low birthweight (ELBW, <1000 g) children aimed to characterise groups with different developmental trajectories from preschool to preteen age.MethodsELBW children (n=115) born in Finland in 1996–1997 participated in cognitive assessments at a median age of 5.0 years and 11.3 years. A standardised test of intelligence (Wechsler Preschool and Primary Scale of Intelligence–Revised or Wechsler Intelligence Scale for Children–third edition) was administered at both ages.ResultsThree ELBW groups with different developmental trajectories over time were identified with latent class growth analysis. Children with average (Full-Scale IQ (FSIQ): 85–115) and below average (FSIQ: <85) intelligence at 5 years of age had significant decreases in intelligence scores by 11 years of age (–11.7 points and –14.9 points, respectively, both p<0.001), while those with above average intelligence (FSIQ: >115) showed stable development (–3.2 points, p=0.250). Multiple linear regression showed that neonatal complications (intraventricular haemorrhage grade 3–4 and blood culture positive sepsis) and maternal education significantly predicted lower intelligence at the second assessment (F(3,106)=7.27, p<0.001, adjusted R2=0.147).ConclusionsELBW children represent a heterogeneous patient population in which groups with different cognitive trajectories can be detected. Deterioration may occur particularly in children with initial average or below average cognitive performance at 5 years of age, with neonatal complications and lower maternal education presenting as risk factors. Catch-up in cognitive functions seems more uncommon in the ELBW population, which should be noted in clinical work.
High-flow nasal oxygen therapy
Authors: Mercadante Sebastiano , Adile Claudio , Ferrera Patrizia , Giuliana Fausto , Grassi Yasmine 
Published: April 2022

ObjectiveTo report data of the use of high-flow nasal therapy (HFNT) in the palliative care setting.MethodsFive hypoxaemic patients were treated by HFNT in a 1-year period in a palliative care setting, either in the last days of life or as part of an intensive treatment for a reversible cause of hypoxic dyspnoea.ResultsFour patients had a similar clinical pattern. After starting HFNT, dyspnoea intensity decreased and oxygen saturation improved, providing a clinical improvement for a duration of 2–3 days, but after 48–72 hours, their conditions deteriorated and patients underwent palliative sedation. Indeed, one patient with pulmonary embolism and pneumonia was treated by HFNT successfully and was discharged home 2 weeks after admission.ConclusionsHFNT may be helpful for severely hypoxaemic patients who are unresponsive to common measures adopted in the last weeks/days of life of patients with advanced cancer or to treat reversible conditions. The findings of this case series showed the ethical and psychological aspects of end of life, particularly for caregivers. Future studies should assess an early use of this device in combination with lower doses of opioids or as an alternative to their use.
Adult patients with congenital heart disease in the intensive care unit
Authors: Ramlakhan Karishma Priyadarshani , van der Bie Maaike , den Uil Corstiaan A , Dubois Eric A , Roos-Hesselink Jolien W 
Published: April 2022

ObjectiveCurrent data on intensive care unit (ICU) admissions in patients with adult congenital heart disease (ACHD) are limited and focus on admissions after elective cardiac surgery. This study describes non-elective ICU admissions in patients with ACHD.MethodsA retrospective matched cohort study was performed from January 2000 until December 2015 in a tertiary care centre ICU (there was no cardiac care unit). Primary outcomes were short-term (during hospital stay or <30 days after discharge) and long-term (>30 days after discharge until end of follow-up) mortality. Outcomes were compared with non-ACHD non-elective ICU admissions, matched 1:1 on age, sex and admission diagnosis.ResultsA total of 138 admissions in 104 patients with ACHD (65.9% male, median age 30 years) were included, during 8.6 years of follow-up. The majority had a moderate-to-severe heart defect. Arrhythmia was the most common admission diagnosis (44.2%), followed by haemorrhage (10.9%), heart failure (8.7%) and pulmonary disease (8.7%). Short-term mortality and total mortality were lower in the ACHD admissions than in the non-ACHD admissions (4.8% vs 16.3%, p=0.005 and 17.3% vs 28.9%, p=0.030), whereas long-term (12.5% vs 12.6%, p=0.700) did not differ. Severe CHD (HR 3.1, 95% CI 1.1 to 8.6) at baseline, and mechanical circulatory support device use (8.3, 1.4 to 47.4) and emergency intervention (0.2, 0.1 to 0.7) during the ICU stay were independently associated with mortality in the ACHD group.ConclusionsNon-elective ICU admissions in patients with ACHD are most often for arrhythmia and in patients with moderate-to-severe CHD. Reassuringly, short-term and total mortality are lower compared with patients without ACHD, however, long-term mortality is higher than expected for patients with ACHD.
Occupational inhalational accidents: analysis of cases from the UK SWORD reporting scheme from 1999 to 2018
Authors: Fishwick David , Carder Melanie , Iskandar Ireny , Fishwick Beth Charlotte , van Tongeren Martie 
Published: April 2022

ObjectiveTo estimate the reported UK incidence of occupational inhalation accidents, and to consider changes of incidence and potential causes over time.MethodsCases of occupational inhalation accident reported to Surveillance of Work Related Occupational Respiratory Diseases (SWORD) over 20 years were grouped into four 5-year time periods. Cases were characterised by causative exposure, occupation and industrial sector. Incidence rates were calculated using Office of National Statistics employment data.ResultsThe 172 actual cases reported to SWORD equated to an estimated 502 cases after adjusting for reporting frequency. Their mean age was 41.3 years (SD 12.3); 77% were male. The annual incidence fell from 1.7 per million employed in the first 5-year period, to 0.5 in the most recent. The most common occupations, responsible for 35% of all cases, were in descending order (number, % of total cases): Labourers in process and plant operations (8, 4.7), welding trades (8, 4.7), fire service officers (8, 4.7), heavy goods vehicle drivers (7, 4.1), metal working production and maintenance fitters (7, 4.1), civil service administrative officers and assistants (7, 4.1), food, drink and tobacco process operatives (6, 3.5), and three summated categories of elementary and service occupations including cleaners and domestics (10, 5.8).Three of 40 exposure categories were common to all time periods; acids (19.6% of all cases 1999–2004, 2.3% 2005–2009, 6.3% 2010–2013, 6.3% 2014–2018), chlorine/hypochlorites (7.2%, 7.0%, 2.5%, 6.3%, respectively) and solvents (14.4%, 11.6%, 12.5%, 6.3%, respectively).ConclusionsThe incidence of inhalation accidents appears to have fallen, although certain exposures appear to be persistently linked to cases.
Non-empirical management of asymptomatic chlamydia and gonorrhoea reduces unnecessary antibiotic use fivefold: a before and after study
Authors: Rasul Rafeeqah , McIver Ruthy , Patel Prital , Foster Rosalind , McNulty Anna 
Published: April 2022

ObjectivesIn 2019, informed by favourable patient and provider acceptability surveys and concerns about antimicrobial resistance, Sydney Sexual Health Centre stopped routinely providing empirical antibiotic treatment to asymptomatic contacts ofChlamydia trachomatis(chlamydia) andNeisseria gonorrhoea(gonorrhoea). We aimed to assess if this policy change had any negative impact on patient outcomes.MethodsA retrospective file review of people who presented as asymptomatic contacts of chlamydia and gonorrhoea cases before and after the policy change was conducted. Data on infection type, test results and treatment were extracted. For contacts who tested positive and were treated non-empirically, additional data were reviewed including sexual activity and symptom or complication development between testing and treatment, time from testing to notification and treatment and loss to follow-up.ResultsOf 1194 asymptomatic sexual contacts of chlamydia or gonorrhoea, most tested negative to both infections (814, 68%). All contacts with a positive result who were not treated empirically were notified of their result and 173 (99%) were treated within a mean time of 5 days. More contacts were overtreated in 2018 (n=355, 58%) under the empirical treatment model compared with 2019 (n=58, 11%, p≤0.001). There was no significant difference in the proportion of contacts who tested positive and were treated (p=0.111) or developed symptoms (p=0.413) before and after the policy change and no contacts who were treated non-empirically developed complications of pelvic inflammatory disease, epididymitis or proctitis between testing and treatment.ConclusionIn this population, a switch from empirically treating all asymptomatic contacts to treating only those who tested positive significantly reduced antibiotic overuse with minimal adverse outcomes. Our findings support results-directed treatment for asymptomatic sexual contacts of chlamydia and gonorrhoea.
Interactions of the doubly charmed state $$T_{cc} ^+$$ with a hadronic medium
Authors: Abreu L. M. , Navarra F. S. , Nielsen M. , Vieira H. P. L. 
Published: April 2022

AbstractWe calculate the cross sections of the processes$$T_{cc}^+ \pi , T_{cc}^+ \rho \rightarrow D^{(*)} D^{(*)} $$Tcc+π,Tcc+ρ→D(∗)D(∗)and of the corresponding inverse reactions. We use effective Lagrangians to account for the couplings between light and heavy mesons, and give special attention to the form factors in the vertices. Using QCD sum rules we calculate here for the first time the$$ T_{cc}^+ - D - D^*$$Tcc+-D-D∗form factor. The$$T_{cc}^+$$Tcc+absorption cross sections are found to be larger than the production ones. We compare our results with the only other existing estimate of these quantities, presented in a work by J. Hong, S. Cho, T. Song and S. H. Lee, in which the authors employed the quasi-free approximation. We find cross sections which are one order of magnitude smaller.