bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the Performance of Outcome Prediction for Inpatients With Acute Myocardial Infarction Based on Embedding Representation Learned From Electronic Medical Records: Development and Validation Study
Authors: Huang Yanqun , Zheng Zhimin , Ma Moxuan , Xin Xin , Liu Honglei , Fei Xiaolu , Wei Lan , Chen Hui 
Published: July 2022

Background
The widespread secondary use of electronic medical records (EMRs) promotes health care quality improvement. Representation learning that can automatically extract hidden information from EMR data has gained increasing attention.

Objective
We aimed to propose a patient representation with more feature associations and task-specific feature importance to improve the outcome prediction performance for inpatients with acute myocardial infarction (AMI).

Methods
Medical concepts, including patients’ age, gender, disease diagnoses, laboratory tests, structured radiological features, procedures, and medications, were first embedded into real-value vectors using the improved skip-gram algorithm, where concepts in the context windows were selected by feature association strengths measured by association rule confidence. Then, each patient was represented as the sum of the feature embeddings weighted by the task-specific feature importance, which was applied to facilitate predictive model prediction from global and local perspectives. We finally applied the proposed patient representation into mortality risk prediction for 3010 and 1671 AMI inpatients from a public data set and a private data set, respectively, and compared it with several reference representation methods in terms of the area under the receiver operating characteristic curve (AUROC), area under the precision-recall curve (AUPRC), and F1-score.

Results
Compared with the reference methods, the proposed embedding-based representation showed consistently superior predictive performance on the 2 data sets, achieving mean AUROCs of 0.878 and 0.973, AUPRCs of 0.220 and 0.505, and F1-scores of 0.376 and 0.674 for the public and private data sets, respectively, while the greatest AUROCs, AUPRCs, and F1-scores among the reference methods were 0.847 and 0.939, 0.196 and 0.283, and 0.344 and 0.361 for the public and private data sets, respectively. Feature importance integrated in patient representation reflected features that were also critical in prediction tasks and clinical practice.

Conclusions
The introduction of feature associations and feature importance facilitated an effective patient representation and contributed to prediction performance improvement and model interpretation.
SIMULTANEOUS QUANTIFICATION OF ACETYLSALICYLIC ACID AND CAFFEINE IN TABLETS BY FIRST-ORDER DERIVATIVE SPECTROSCOPY
Authors: MEDINA-LOPEZ JOSE RAUL , GONZALEZ-SALAZAR OMAR ALEJANDRO , CONTRERAS-JIMENEZ JUAN MANUEL 
Published: July 2022

Objective: To develop an apply a new and easy UV-derivative method for the simultaneous quantification of acetylsalicylic acid (ASA) and caffeine (CAF) in commercial tablets. Derivative spectroscopy is an analytical methodology used to identify drugs in a mixture of two or more compounds without use of toxic dissolvents that are involved in chromatographic determinations.
Methods: Standard solutions of ASA (40-120 µg/ml) and CAF (5-25 µg/ml) were prepared with 0.1 M phosphate buffer pH 7.4. The zero-order spectra were determined from 200-300 nm. The method was validated according to International Conference on Harmonization (ICH) guidelines. An USP Apparatus 2 at 75 rpm with 900 ml of 0.1 M phosphate buffer pH 7.4 was used. For each drug, common dissolution data as the amount of drug released at 60 min (Q60), mean dissolution time (MDT), dissolution efficiency (DE), t50% and t85% were calculated.
Results: ASA was identified at 245 nm and CAF at 295 nm in the first-derivative mode. The method was linear (R2>0.99, *P<0.05). The precision and accuracy of the method were within acceptable limits. Q60, MDT, DE, t50%, and t85% values for ASA were 102.09%, 8.18 min, 88.15%, 2.91 min, and 11.98 min, respectively. Same parameters for CAF were 99.17%, 5.21 min, 90.54%, 1.09 min, and 5.70 min, respectively.
Conclusion: The proposed UV-derivative method is rapid and simple and can be easily adopted to determine the in vitro release curves of ASA and CAF from commercial tablets. The method generates reliable information that can be compared with published data.
Trends, Challenges and Opportunities at University of Manitoba Libraries during the COVID Pandemic
Authors: Xuan Wei , Shaw Christine 
Published: July 2022

The COVID-19 pandemic brought rapid and radical changes to higher education, and academic libraries adapted and devised solutions. This article will review the initiatives that the University of Manitoba Libraries (UML) implemented prior to the pandemic, as well as the library’s response, focusing on the performance of these initiatives in the past two years. These initiatives are new service models including a fully virtual library, new technologies, such as self-service lockers, and structural reorganization, for example, the creation of functional teams. The review will demonstrate how the above initiatives ensured the continuity of library services during the pandemic. The pandemic is viewed as a touchstone that tested the trends of the academic library community in an extreme situation. The success of the library services provided by the UML inspires positive thinking about the forward direction for public research university libraries.
Impact of Honeybee Venom Melittin on Cell Viability of Different Prostate Cancer Lineages
Authors: Khalikov R. R. , Gromenko D. D. , Galimova S. Sh. , Danilko K. V. , Gromenko I. D. , Galimov Sh. N. , Litvitsky P. F. 
Published: July 2022

Background. Melittin is a major constituent of honeybee venom and comprises a water-soluble surfactant peptide with cytolytic effects potentially applicable in anticancer therapy. We evaluated the impact of melittin from Bashkir honeybee (Apis mellifera mellifera L.) venom on cell viability of various prostate cancer lineages.Materials and methods. MTT assays with cell viability index estimation were used to evaluate the effect of melittin on cell proliferation in various-grade malignancy prostate cancer (PC) lineages, LNCaP, PC-3 and DU145.Results and discussion. Lineage DU145 revealed a low sensitivity to melittin, because a relatively high peptide concentration of 10 μg/mL had a suppressive effect on its proliferation. With PC-3 cells, a 0.1 μg/mL concentration suppressed proliferation significantly to 46.15 %, while melittin at a 10 μg/mL dose had a cytolytic effect on most cells (4.27 % viability). LNCaP cells experienced the lowest toxicity at 10 μg/mL melittin compared to PC-3 and DU145 lineages. The LNCaP, PC-3 and DU145 PC lineages demonstrated suppressed proliferation at melittin levels 0.01–100 μg/mL.Conclusion. The study reveals a significant reduction of the PC lineages viability at a minimal melittin concentration of 0.01 μg/mL, which indicates a high cytolytic activity of this peptide and renders it a candidate agent in antitumour therapy.
The Complication Of Decrease In Aorto-Mesenteric Angle And Distance Its Diagnosis And Treatment: Case Report
Authors: Galimov O. V. , Khanov V. O. , Karkhani H.M. H. , Bhawna Sh. , Ibragimov T. R. 
Published: July 2022

Introduction. Wilkie syndrome is a pathological manifestation caused by an abnormal disorder of the superior mesenteric artery arising from the abdominal part of the aorta. As a result, the distal part of the duodenum is compressed between the abdominal aorta, spine, and SMA, which creates a hindrance for the passage of himus in the duodenum, creating a mechanical obstruction.Aim: To draw the surgeons’ attention towards the possibility of developing a rare complication of decreased aorto-mesenteric angle and the distance, highlighting the challenges in diagnosis and treatment.Materials and methods. This article presents a clinical case of WS diagnosed in the surgical department of the BSMU clinic. We hereby discuss the case report of a 28-year-old patient diagnosed at the initial stage of WS. The patient had been suffering from the symptoms of WS since 2018 but wasn’t able to identify the disease, but when he came to the surgical department of BSMU clinic based on the results of abdominal CT-scan with combined contrast of the stomach and duodenum per os with water-soluble contrast and computer angiography of the mesenteric vessels, the diagnosis was confirmed. The patient was treated with the duodenojejunostomy (laparoscopic Strong’s operation).Results and discussion. Absence of timely diagnosis of this disease can lead to life-threatening complications, and early diagnostics is complicated by similarity of initial manifestations with other gastropancreaticoduodenal diseases. One of the most promising approach in the diagnosis of Wilkie syndrome is the use of abdominal CT-scan with combined contrasting of the stomach and duodenum per os with water-soluble contrast and computer angiography of vessels. In the present clinical case due to the given combination of methods we can assess functional state of the stomach and duodenum, clearly visualize not only the organs topography but also estimate the aorto-mesenteric angle and distance, which can further determine the type and tactics of initial stage treatment, which we decided to perform surgery (laparoscopic Strong’s operation). The postoperative period was without complications. The patient noted an improvement in the state and the relief of pain in the epigastrium and was discharged after 9 days of hospitalization in satisfactory condition.Conclusion. For diagnosis and treatment in time as well as prevention of possible complications, it is necessary to improve surgeons’ information about this pathology, which if diagnosed and treated late can lead to severe, life-threatening complications up to death. The diagnosis at the initial stages, specifically with the assistance of computer tomography with contrast, angiography, and treatment in a timely manner, can preserve life and prevent the possible outcomes of fatal complications.
PERANCANGAN APLIKASI PENGOLAHAN DATA SISWA PADA SMK ISLAM BINA KHALIFAH BANGSA KOTA METRO
Authors: Anshori Muhammad Afan , Irawan Dedi 
Published: July 2022

Pengolahan data siswa yang efektif dan efesien merupakan syarat wajib agar kegiatan belajar dan mengajar berjalan lancar. Begitu juga dengan SMK Islam Binda Khalifah Bangsa Kota Metro. Permasalahan yang ditemui selama melakukan penelitian, yaitu Pengolahan data siswa di SMK Islam Bina Khalifah Bangsa masih menggunakan Ms. Excel, dalam pengolahan data tersebut masih kurang optimal karena dalam penginputan data siswa masih memerlukan waktu yang cukup lama. Kemudian ditemukan permasalahan pada pembuatan laporan data siswa yang masih dalam berupa kertas/arsip data dari tahun sebelumnya, sehingga pembuatan laporan sering terjadi keterlambatan. Pelayanan yang masih menggunakan proses manual maka akan menimbulkan lambatnya kinerja pada pelayanan siswa pada SMK Islam Bina Khalifah Bangsa Metro. Tujuan dari penelitian yang dilakukan pada SMK Islam Bina Khalifah Bangsa Metro adalah untuk membuat aplikasi pengolahan data siswa mulai dari penginputan data siswa sampai dengan menghasilkan keluaran berupa laporan-laporan data pada SMK Islam Bina Khalifah Bangsa Metro. Metode penelitian yang digunakan oleh peneliti terdiri dari dua bagian, yaitu metode berdasarkan jenis penelitian (Applied Research) dan teknik pengumpulan data pengamatan (observasi), wawancara (interview), dokumentasi (documentation) dan studi kepustakaan (library research). Aplikasi dirancang menggunakan pendekatan pemrograman terstruktur yang berbasis desktop. Metode pengembangan aplikasi menggunakan SDLC (System Development Life Cycle) dengan teknik pengujian aplikasi menggunakan teknik Black Box Testing. Bahasa pemrograman yang digunakan adalah Borland Delphi 7.0 dan database yang digunakan adalah Microsoft acces. Alat pengembangan sistem yang digunakan antara lain flowchart, diagram konteks, dfd, erd, dan flowchart. Hasil dari penelitian adalah sebuah Aplikasi Pengolahan data pada SMK Islam Bina Khalifah Bangsa Metro Berbasis Desktop.
Analisa pengaruh jarak cutting torch terhadap permukaan berputar pada mesin pemotong kontur sambungan pipa
Authors: Akhyan Amnur , Salam Hadi 
Published: July 2022

Currently steel pipes are needed, especially in construction work. Construction with pipe materials cannot be separated from the process of joining and cutting. The cutting process for large pipes always uses a thermal cutting process. This study aims to determine how much influence the cutting distance has on the cutting results on a pipe that rotates at a constant 0.8 rpm following the shape of the corner joint contour. To achieve the objectives of this study, a pipe cutting tool with a diameter of 4 to 6 inches is needed with the thermal cutting method using the Oxy Acetylene Cutting (OAC) process This research data was obtained by cutting the 4inch pipe schedule 10s, schedule 20s and schedule 40s in a rotating condition and the cutting torch moves back and forth. The pipe rotates at 0.8 rpm using an AC motor transmitted using a gearbox connected to the wheel as a holder where the pipe rotates. The results of the cutting are in the form of a pipe connection contour with an angle of 900 and 600. As the independent variable in this study was set the cutting distance is 5mm, 7mm and 10 mm, while the fixed variables are determined by cutting speed 280 mm/minute, acetylene gas pressure 3.5 kg/cm2 and oxygen 17.5 kg/cm2. In order to get effective results, preheat the surface of the pipe with a gas fuel mixture until it reaches the melting temperature of the pipe as the main ingredient. The cutting results that meet the entire path of the pipe can be cut completely and through and there is very little splash or melt dirt during the cutting process. After cutting, the best results are obtained at a cutting distance of 5 mm both on schedule 10s, schedule 20s and schedule 40s.
Associations of serum vitamin D and Fok I polymorphism of receptor gene with unexplained recurrent spontaneous abortion
Authors: Liu Hebin , Song Yujuan , Zhou Menglan , Yao Xiaoling 
Published: July 2022

Abstract

Background: To investigate the associations of serum vitamin D and Fok I polymorphism of its receptor (VDR) with unexplained recurrent spontaneous abortion (URSA).

Methods: Ninety URSA patients and another 104 healthy pregnant women were selected as URSA and control groups, respectively. 25-Hydroxyvitamin D [25-(OH)D] level was detected by chemiluminescence. VDR gene Fok I polymorphism was analyzed by PCR, and the distribution of genotype frequency was calculated by Hardy-Weinberg equilibrium test. Association between Fok I polymorphism and susceptibility to URSA was investigated by logistic regression analysis.

Results: Gestational age, uterine height, waist circumference, 25-(OH)D level and proportions of Fok I FF and Ff genotypes were significantly lower in the URSA group (P<0.05). Compared with ff genotype, risk of URSA reduced for Ff and FF genotypes. Compared with allele f, risk of URSA was lower for allele F. 25-(OH)D level of ff genotype was significantly lower in the URSA group, which was lower than that of FF genotype (P<0.05). Compared with women with 25-(OH)D level >30 ng/mL and F allele (FF+Ff), the risk of URSA increased 2.45-, 2.43- and 5.34-fold for those with 25-(OH)D level >30 ng/mL and ff genotype, with 25-(OH)D level ≤30 ng/mL, and with ff genotype and 25-(OH)D level ≤30 ng/mL, respectively.

Conclusions: The 25-(OH)D level of the URSA group was significantly lower than that of normal pregnant women. Probably, VDR gene Fok I polymorphism is associated with URSA occurrence, and allele F decreases the risk. The risk of URSA dramatically increases in women with ff genotype and 25-(OH)D deficiency.
Associative learning impairments in rats lacking dopamine transporter
Authors: Savchenko A. A. , Sukhanov I. M. , Ulitina A. S. , Dravolina O. A. , Belozertseva I. V. , Emelianov A. K. , Zvartau E. E. 
Published: July 2022

Introduction. Changes in the expression of the dopamine transporter (DAT) have been identified in patients with a number of neuropsychiatric disorders, but their significance for pathogenesis remains unclear. DAT knockout rats are a promising model of frontostriatal dysfunctions involved in adapting learning processes to current organism's needs, motivation, and experience.The objective was to evaluate the effect of DAT disruption on the interaction of classical and instrumental conditioning processes (associative learning).Methods and materials. Rats from a local colony were used: knockouts (n=31), heterozygotes (n=32), and wild type rats (n=24). DAT knockout (Slc6a3) was detected by PCR followed by restriction analysis. The rats were kept individually with limited access to food and unlimited access to water. In the operant chambers equipped with a MED-PC interface (MED Associates, USA), 3 experiments were performed: 1) classical conditioning; 2) autoshaping of operant responding; 3) reward learning based on secondary reinforcement. Statistical analysis was performed using SigmaPlot 12.5 (Systat Software Inc., USA) and SPSS Statistics 21 (IBM, USA).Results. We revealed that DAT disruption in rats did not affect the formation of conditioned reflex connections in classical conditioning (1) but was accompanied by impairments in the autoshaping of the operant response (2) and learning based on secondary reinforcement (3).Conclusion. The observed impairments of associative learning might be associated with a decreased incentive value of stimuli in hyperdopaminergic state.
Analysis of the Clinical Characteristics of Patients with Malignant Neoplasms of the Pancreas Who Received Medical Care in Hospitals in St. Petersburg in the Period from 2015 to 2020
Authors: Moiseenko V. E. , Ponomarev P. A. , Pavlovsky A. V. , Granov D. A. , Kochorova L. V. , Vishnyakov N. I. 
Published: July 2022

The objective of the study was the analysis of the main clinical characteristics identified in patients with malignant neoplasms of the pancreas, who received medical care in healthcare institutions of St. Petersburg in the period from 2015 to 2020.Methods and materials. A continuous study of clinical and statistical data of patients with pancreatic cancer receiving medical care in healthcare institutions of St. Petersburg (of federal and city subordination) for the period from 01.2015 to 02.2020 was carried out. In total, the study included depersonalized medical cards of 2141 patients diagnosed with pancreatic cancer.Results. During the studied period, more than half of the patients diagnosed with cancer of the pancreas received medical care in specialized oncological institutions of city subordination, a third – in federal institutions, 11.3 % – in multidisciplinary city hospitals. The maximum number of cases was in patients of older age groups: 41.7 % – 70 years and over, including 15.4 % – 80 years and over. The majority (39.7 %) of new patients with pancreatic cancer hospitalized in medical institutions of St. Petersburg were diagnosed with stage IV of the disease. The disease, according to examinations, was represented by stage III in 29.7 % of patients at the time of initial hospitalization. The pancreatic cancer was presented with stage III in 20 % of the patients. The disease was registered in 4.4 % of patients at stage I. Stage 0 or carcinoma in situ was diagnosed at initial presentation in 4.7 % of patients. The stage of the disease was not determined in 1.4 % of patients. The tumor was located in the head of the pancreas in 64.4 % of patients. The most common histological type of pancreatic cancer is ductal adenocarcinoma, which was verified in 72.0 % of patients. Type 2 diabetes mellitus was registered in 37 % of patients as concomitant disease.Conclusion. The results of the analysis of clinical and statistical data of patients with pancreatic cancer may become a background for conducting research on the early detection of this neoplasm.
Acute biliary pancreatitis: the evolution of surgical tactics (review of literature)
Authors: Nikitina T. O. , Popov D. N. , Korolkov A. U. , Bagnenko S. F. 
Published: July 2022

Surgical treatment of acute biliary pancreatitis over the past decades have been improved from realization of open traumatic surgical interventions to the use of minimally invasive technologies. However, despite the progress in the treatment of this pathology, the question of the timing of cholecystectomy after endoscopic papillosphincterotomy with lithoextraction remains unresolved. In some cases, after the endoscopic papillosphincterotomy, a recurrence of the disease occurs, as well as other various biliary complications, such as: acute calculous cholecystitis, choledocholithiasis, cholangitis, associated with the fact that the main etiological factor – the gallstone disease – has not been eliminated, specifically, cholecystectomy was not performed.The objective of this study was to analyze the evolution of surgical tactics in the treatment of acute biliary pancreatitis with combined cholecystocholedocholithiasis.
Experimental Investigation of Poly(methyl Methacrylate) Cooling Beds for Warm Gas Generator Applications
Authors: Patel Amit , Frederick Robert A. 
Published: July 2022

Throttleable solid propulsion systems are sometimes supplied using solid gas generator systems. Solid propellants, such as ammonium perchlorate-based composites, have been extremely useful for boost propulsion, but flame temperatures generally exceed material limitations of valve-controlled thrusters. The objective of this research is to experimentally investigate the use of a solid propellant flowing through a deflagrating cooling bed to lower gas temperatures for warm gas controllable thrusters. A nonaluminized, ammonium perchlorate solid propellant generated hot combustion gases that flowed through a polymethyl methacrylate (PMMA) coolant chamber. The cooling chamber contained a PMMA center-perforated cylinder as a cooling material. Experiments were conducted in a constant pressure chamber and in laboratory-scale solid rocket motors at pressures up to 600 psi. The results showed that as the mass flux of the hot gases increased, so did the regression rate of the coolant material. The initial and final PMMA profiles of the cooling material were used to develop a PMMA regression rate correlation as a function of average gas flux. The average mass flux ranged from 0.067 to [Formula: see text], whereas the regression rate ranged from 0.008 to 0.044 in./s. The net cooling effect ranged from 510 to [Formula: see text]. The Nusselt number correlations are also presented for the warm gas generator.
HÁBITOS SOBRE CONSUMO RESPONSABLE EN ESTUDIANTES DE UNA UNIVERSIDAD DE LA REGIÓN DE LAMBAYEQUE
Authors: Vásquez Muñoz Antenor , Morales Huamán Humberto Iván , Silva Siesquen José Alberto , Rivas Manay Roberh Manuel , García Calderón Oscar Martín 
Published: July 2022

La investigación tuvo como objetivo determinar el nivel de hábitos sobre consumo responsable en estudiantes de una universidad en la Región de Lambayeque. Para ello, se utilizó un diseño no experimental, empleando la encuesta como técnica y el instrumento cuestionario de preguntas. La metodología se basó en encuestar en forma aleatoria simple no estratificada de acuerdo con el interés de los investigadores en una sola oportunidad a 220 estudiantes que pertenecen al primer ciclo académico 2021-II de la universidad Señor de Sipán. Llegando a obtener resultados donde se evidencian el bajo nivel del consumo responsable por parte de los estudiantes universitarios participantes, donde se puede concluir el rol que juega la universidad para mejorar el nivel de hábitos de consumo en los estudiantes universitarios, donde sirvan de ejemplo a las demás personas de su entorno sobre buenos hábitos de consumo responsable.