bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of time to recovery from uncomplicated severe acute malnutrition among 6–59 months children treated in out patient treatment in health posts of Nagele Arsi district: a retrospective cohort study
Authors: Tsegaye Ashenafi , Lencha Bikila , Kumsa Kebede 
Published: December 2022

Abstract
Background
Access to outpatient therapeutic feeding programs (OTP) for all children who have uncomplicated severe acute malnutrition (SAM) remains a global public health priority. Identifying predictors that determine time-to-recovery from severe acute malnutrition optimize therapeutic success. However, reliable evidence on the determinants of time to recovery at health posts was not available in Nagele Arsi district of South Ethiopia.

Objective
This study was aimed to identify determinants of time-to-recovery from uncomplicated SAM among children aged (6–59) months treated at an OTP in health posts of Nagele Arsi district, Southern Ethiopia.

Methods
Institutional based retrospective cohort study was conducted among 357 children treated in Negele Arsi district from July1, 2018 to June 30, 2020. The children were selected using simple random sampling from 20 health posts. SAM treatment outcomes were compared against international SPHERE standards. The average time-to-recovery was estimated using Kaplan-Meier survival curve and the independent predictors of time to recovery were determined using multivariable Cox-proportional hazard model. The strength of the association was done using adjusted hazard ratio (AHR) with 95% confidence intervals. Statistical significance was declared at p value < 0.05. The results were presented by text, tables and figures.

Result
A total of 284 (79.6%) children recovered during follow up. The mean weight gain for recovered children was 4.7 + 2.4 g/kg/day. The median time-to-recovery was 44 days 95% CI (42.7–45.3). Children who received Amoxicillin, AHR =2.574, 95% CI (1.879–3.525); de-wormed, AHR = 1.519, 95% CI (1.137–2.031); received Vitamin A, AHR = 2.518, 95% CI, (1.921–3.301) and new admissions, AHR = 1.823, 95%CI, (1.224–2.715) were more likely to recover. However, those who admitted with non-edema, AHR = 0.256, 95% CI, (0.189–0.346); had cough at admission, AHR = 0.513, 95 CI, (0.366–0.719) and had diarrhea at admission AHR = 0.5, 95% CI, 0.5 (0.350–0.712) were less likely to recover.

Conclusion and recommendation
The recovery rate was within the acceptable ranges of International Sphere Standards. Those children who had cough and diarrhea should be given due attention from health extension workers and program planners. Appropriate provision of routine medication and timely intervention of co-morbidity are needed to increase chance of early recovery.
A comparative analysis of the work environments for registered nurses, nurse aides, and caregivers using the 5th Korean Working Conditions Survey
Authors: Kim Sung Shin , Kim Yun Jin , Park Jun Sik , Ho Seoung Hee , Kweon Hyosun , Bae Young-Hyeon 
Published: December 2022

Abstract
Background
Since the quality of work life of healthcare workers is affected by various factors, an improvement in their work environment can reduce the burden on them, increasing their performance. This study aimed to identify the current problems in working environments for registered nurses (RNs), nurse aides (NAs), and caregivers using the 5th Korean Working Conditions Survey (KWCS), presenting measures to improve working conditions by analyzing their predictors: 1) degree of exposure to work-related risk factors (musculoskeletal and mental), 2) working patterns, 3) work-family balance, 4) work situations, and 5) self-rated health.

Methods
The sampling frame was a list of apartment and general survey zones, excluding islands, dormitories, special social facilities, tourist hotels, and foreigner zones, among the total survey zones of the 2010 Population and Housing Census. The KWCS was given to 50,205 participants of various occupations, and responses from 494 RNs, 201 NAs, and 505 caregivers were extracted to compare their 1) degree of exposure to work-related risk factors (musculoskeletal and mental), 2) working pattern, 3) work-family balance, 4) work situations, and 5) self-rated health.

Results
The response rate was 0.449. There were significant differences in all the variables (exposure to musculoskeletal and mental work-related risk factors, working pattern, work-family balance, work situations, self-rated health, and satisfaction with working conditions) among RNs, NAs, and caregivers (p < 0.001). The degree of work-related musculoskeletal and mental risk exposure was higher among caregivers and RNs than among NAs; irregular working patterns, challenges with work-family balance, and work environment satisfaction were higher among caregivers than among NAs. In addition, work situations were poorer among caregivers and NAs than among RNs. Self-rated health was the highest among caregivers, followed by RNs and NAs. The most potent predictor of self-rated health was occupation, followed by work environment satisfaction and work-family balance; the most potent predictor of work environment satisfaction was self-rated health, followed by degree of exposure to work-related musculoskeletal and mental risk factors, occupation, work-family balance, work situation, and working patterns.

Conclusion
This study confirmed that a variety of factors influence work environment satisfaction. Thus, practical and realistic measures to improve work environments tailored to each healthcare occupation should be developed at the national and community levels. Further qualitative studies are needed to analyze the work environments of nurses and other care workers in depth.
Higher fasting blood glucose worsens knee symptoms in patients with radiographic knee osteoarthritis and comorbid central sensitization: an Iwaki cohort study
Authors: Chiba Daisuke , Ohyama Tetsushi , Sasaki Eiji , Daimon Makoto , Nakaji Shigeyuki , Ishibashi Yasuyuki 
Published: December 2022

Abstract
Background
Although cross-sectional and cohort data suggest that higher serum blood glucose levels in patients with knee osteoarthritis (KOA) are associated with more severe knee symptoms, little is known about the longitudinal relationship between serum blood glucose and knee symptoms, particularly considering central sensitization (CS) comorbidity, which also worsens knee symptoms.

Methods
We evaluated the longitudinal relationship between serum blood glucose and knee symptoms by dividing the cohort of patients with KOA into those with and without CS. We hypothesized that higher serum blood glucose levels would worsen knee symptoms. A total of 297 participants (mean age: 59.6 years; females: 211; average BMI: 23.7 kg/m2) were enrolled in this study. At baseline, plain radiographs of the bilateral knee joints were evaluated according to the Kellgren–Lawrence grade (KLG). All participants exhibited at least a KLG ≥ 2 in each knee. At baseline, fasting blood glucose (FBG) and Central Sensitization Inventory-9 (CSI-9) were evaluated; ≥ 10 points on the CSI-9 was defined as CS+. Knee injury and Osteoarthritis Outcome Score (KOOS) was evaluated at baseline and at 1-year follow-up; the change in KOOS (ΔKOOS) was calculated by subtracting the KOOS at baseline from that at the 1-year follow-up. Multiple linear regression analysis was conducted with ΔKOOS as the dependent variable and FBG at baseline as the independent variable, adjusted for age, sex, BMI, and CSI-9 at baseline.

Results
Of the 297 subjects, 48 (16.2 %) were defined as CS+. In the CS − group, there was no association between FBG levels at baseline and ΔKOOS. In contrast, FBG at baseline was negatively associated with ΔKOOS pain (B = − 0.448; p = 0.003), ADL (B = − 0.438; p = 0.003), and sports (B = − 0.706; p = 0.007).

Conclusions
In patients with radiographic KOA and CS, higher blood glucose levels were associated with deteriorated knee symptoms during the 1-year follow-up. Healthcare providers should pay attention to controlling blood glucose, particularly in patients with KOA and concurrent CS, to mitigate their knee symptoms.

Study design
Retrospective cohort study (evidence level: III).
Nivolumab Plus Cabozantinib With or Without Ipilimumab for Advanced Hepatocellular Carcinoma: Results From Cohort 6 of the CheckMate 040 Trial
Authors: Yau Thomas , Zagonel Vittorina , Santoro Armando , Acosta-Rivera Mirelis , Choo Su Pin , Matilla Ana , He Aiwu Ruth , Cubillo Gracian Antonio , El-Khoueiry Anthony B. , Sangro Bruno , Eldawy Tarek E. , Bruix Jordi , Frassineti Giovanni Luca , Vaccaro Gina M. , Tschaika Marina , Scheffold Christian , Koopmans Petra , Neely Jaclyn , Piscaglia Fabio 
Published: December 2022

PURPOSE To investigate the safety and efficacy of nivolumab plus cabozantinib with or without ipilimumab in patients with advanced hepatocellular carcinoma. METHODS In cohort 6 of the multicohort, open-label, phase I/II CheckMate 040 study, patients who were treatment-naive, sorafenib-intolerant, or had progressed on sorafenib were randomly assigned 1:1 to nivolumab 240 mg once every 2 weeks plus cabozantinib 40 mg once daily (doublet arm); or nivolumab 3 mg/kg every 2 weeks plus cabozantinib 40 mg once daily with ipilimumab 1 mg/kg once every 6 weeks (triplet arm). Primary objectives were safety and tolerability, objective response rate, and duration of response by investigator assessment per RECIST v1.1. Secondary objectives included progression-free survival (by blinded independent central review) and overall survival. RESULTS Seventy-one patients were randomly assigned: 36 to the doublet arm and 35 to the triplet arm. After 32.0-month median follow-up, objective response rate (95% CI) was 17% (6 to 33) and 29% (15 to 46) in the doublet and triplet arms, respectively. Median (95% CI) duration of response was 8.3 (6.9 to not estimable) months in the doublet arm and not reached (0.0 to not estimable) in the triplet arm. Median progression-free survival was 5.1 and 4.3 months, and median overall survival was 20.2 and 22.1 months for the doublet and triplet arms, respectively. Grade 3-4 treatment-related adverse events occurred in 50% and 74% of patients and treatment-related adverse events leading to discontinuation were reported for 11% and 23% in the doublet and triplet arms, respectively. There were no treatment-related deaths in either arm. CONCLUSION Nivolumab plus cabozantinib with or without ipilimumab showed encouraging preliminary antitumor activity and had consistent safety profiles with those established for the individual drugs in patients with advanced hepatocellular carcinoma.
Evolution of Transradial Access for Mechanical Thrombectomy—A Single Center Experience
Authors: Munich Stephan A. , Saganty Ruth S. , Joshi Krishna C. , Radaideh Yazan 
Published: December 2022

BACKGROUND:
Transradial access (TRA) recently has gained popularity among neurointerventionalists. However, hesitation to its use for mechanical thrombectomy (MT) remains.

OBJECTIVE:
To evaluate and describe the evolution of TRA for MT.

METHODS:
We performed a retrospective analysis of patients undergoing TRA for MT. We performed a chronological ternary analysis to assess the impact of experience. We assessed the impact of a guide catheter designed specifically for TRA.

RESULTS:
We identified 53 patients who underwent TRA for MT. There was a statistically significant decrease in contrast use (148.9 vs 109.3 vs 115.2 cc), procedure time (62.4 vs 44.7 vs 41.3 minutes), fluoroscopy time (39.2 vs 44.7 vs 41.3 minutes), and puncture-to-recanalization time (40.6 vs 27.3 vs 29.4) over time. There was trend toward improved thrombolysis in cerebral infarction ≥ 2b recanalization rate (72.2% vs 77.8% vs 100%) over time. The introduction of a radial-specific catheter had a statistically significant positive impact on contrast use (133.8 vs 93 cc, P = .043), procedure time (54.2 vs 36.4 minutes, P = .003), fluoroscopy time (33.7 vs 19.8 minutes, P = .004), puncture-to-recanalization time (35.8 vs 25.1 minutes, P = .016), and thrombolysis in cerebral infarction ≥ 2b recanalization rate (71.4% vs 100%, P = .016).

CONCLUSION:
TRA is a safe and effective route of endovascular access for MT. Experience with this technique improves its efficacy and efficiency. The introduction of a TRA-specific catheter expands the armamentarium of the neurointerventionalist and may facilitate lesion access during MT procedures. Continued development of radial-specific devices may further improve MT outcomes.
How Does COVID-19 Affect Marine Insurance Cover Through the Requirement of Seaworthiness?
Authors: Al-Daboubi Derar , Al-Kasassbeh Fahad 
Published: December 2022

This paper addresses the legal implications of COVID-19 upon the procurement of marine cargo insurance cover. It clarifies the relationship between warranty of seaworthiness and duty of disclosure, both of which are imposed upon the insured cargo owner under contract of marine insurance. The paper discusses the effect of COVID-19 that the insured cargo owner may invoke to rebut the allegation of not satisfying the duty of disclosure in terms of the seaworthiness of a vessel, which may deprive the insured cargo owner of compensation. The study deploys qualitative and black letter approaches by analysing English and US law, and the relevant international documents. The authors suggest that US law should adopt the same approach as English law, so that the insured cargo owner will not be forced to prove the relation between the restrictions imposed under COVID-19 and its failure to disclose material facts related to seaworthiness.
ANALISIS PERBEDAAN RETURN SAHAM SEBELUM & SESUDAH HARI RAYA IDUL FITRI DAN IDUL ADHA
Authors: Firdaus Revo Gilang 
Published: December 2022

Penelitian ini bertujuan untuk menganalisis perbedaan return saham sebelum dan sesudah hari raya idul fitri serta idul adha pada Indeks Saham Syariah Indonesia (ISSI) pada periode 2016 â€“ 2020. Metode yang digunakan adalah dengan mengobservasi harga saham sebelum dan sesudah hari raya idul fitri serta idul adha pada ISSI yang kemudian dilanjutkan dengan melakukan statistik deskriptif, uji normalitas menggunakan Shapiro Wilk, Uji Wilcoxon Signed Rank, dan Paired Sample t-test menggunakan software SPSS versi 22. Hasil menunjukkan bahwa data tidak terdistribusi normal pada X2/return setelah idul fitri. Maka return saham sebelum dan sesudah hari raya idul fitri dilakukan menggunakan uji Wilcoxon Signed Rank dengan signifikansi sebesar 0,08 yang berarti tidak terdapat perbedaan return saham sebelum dan sesudah hari libur idul fitri. Sedangkan hasil X3 dan X4 menunjukkan data terdistribusi normal sehingga uji yang dilakukan adalah Paired t-test. Nilai signifikansi didapatkan 0,187 yang berarti tidak terdapat perbedaan return saham sebelum dan sesudah hari libur idul adha.Penelitian ini bertujuan untuk menganalisis perbedaanÂ returnÂ saham sebelum dan sesudah hari raya idul fitri serta idul adha pada Indeks Saham Syariah Indonesia (ISSI) pada periode 2016 â€“ 2020. Metode yang digunakan adalah dengan mengobservasi harga saham sebelum dan sesudah hari raya idul fitri serta idul adha pada ISSI yang kemudian dilanjutkan dengan melakukan statistik deskriptif, uji normalitas menggunakanÂ Shapiro Wilk, UjiÂ Wilcoxon Signed Rank, danÂ Paired Sample t-testÂ menggunakanÂ softwareÂ SPSS versi 22. Hasil menunjukkan bahwa data tidak terdistribusi normal pada X2/returnÂ setelah idul fitri. MakaÂ returnÂ saham sebelum dan sesudah hari raya idul fitri dilakukan menggunakan uji Wilcoxon Signed Rank dengan signifikansi sebesar 0,08 yang berarti tidak terdapat perbedaanÂ returnÂ saham sebelum dan sesudah hari libur idul fitri. Sedangkan hasil X3 dan X4 menunjukkan data terdistribusi normal sehingga uji yang dilakukan adalah Paired t-test. Nilai signifikansi didapatkan 0,187 yang berarti tidak terdapat perbedaanÂ returnÂ saham sebelum dan sesudah hari libur idul adha.
ENHANCING MSME'S MARKETING PERFORMANCE THROUGH INNOVATION CAPABILITY MEDIATED BY TECHNOLOGY CAPABILITY AND VALUE-BASED SELLING
Authors: Pantjologiningroem Dewi Sri Woelandari , Vikaliana Resista , Setyawati Novita Wahyu 
Published: December 2022

Introduction to The Problem: During the global Covid-19 pandemic, with social restrictions, digital marketing became a demand.Â Plenty of MSMEs are unable to adapt to digital marketing quickly. It depends on innovation capabilities and technology capabilities of MSMEs, as well as an understanding of value-based selling.Purpose: This study examines whether innovation capabilities are able to improve MSME marketing performance mediated by technology capabilities and value-based selling.Methodology: A quantitative approach is used in this research with Structural Equation Modeling (SEM) modeling.Â The questionnaire was distributed to 39 samples of MSMEs in Java, with purposive sampling..Findings: SEM model testing shows that innovation capabilities have a positive and significant effect on improving the marketing performance of MSMEs, both directly and indirectly. Both technology capabilities and value-based selling are able to mediate the capacity for innovation to improve the marketing performance of MSMEs.Â Â Â Paper Type: Research Article
Arthropofauna consumed by the Andean night monkey (Aotus lemurinus) in a forest fragment at the Cordillera Central Colombia
Authors: Montilla Sebastián O. , Arcila-Pérez Luisa F. , Fonseca Manuel L. , Link Andrés 
Published: December 2022

Los artrópodos son alimento importante para primates como los monos nocturnos (Aotus spp.) debido a que proveen proteínas y grasas fáciles de digerir. No obstante, el registro de su consumo ha sido subestimado por la naturaleza oportunista de su captura y por las dificultades en la identificación. Describimos el consumo de artrópodos por parte de un grupo del mono nocturno andino en un bosque fragmentado de Colombia. Entre marzo y junio de 2016, recogimos muestras fecales a partir de seguimientos nocturnos y visitas al dormidero de un grupo de 4 individuos del mono nocturno andino (Aotus spp.). Preservamos las muestras en alcohol al 96 % y posteriormente las visualizamos a partir de un estereoscopio. Se inspeccionaron las heces en búsqueda de fragmentos de artrópodos que posteriormente fueron determinados a nivel taxonómico de orden y familia. En 12 de las 15 heces analizadas encontramos 48 fragmentos de artrópodos, de los cuales se clasificaron 38 a nivel de orden y 16 a nivel de familia. En total, identificamos 7 órdenes de artrópodos (6 insectos y 1 arácnido) y 9 familias de insectos (5 Coleoptera, 3 Hemiptera y 1 Hymenopera). Los órdenes con mayor cantidad de fragmentos en las heces fueron Coleoptera (21), Hemiptera (5) y Orthoptera (5) y las familias más frecuentes fueron Elateridae y Curculionidae con 5 y 4 fragmentos, respectivamente. Reportamos por primera vez el consumo del orden Isoptera, así como 2 nuevas familias de Hemiptera (i.e., Coreidae and Pentatomidae) y 5 familias de Coleoptera (i.e., Chrysomelidae, Coccinellidae, Curculionidae, Elateridae y Staphylinidae) en la dieta de los monos nocturnos (Aotus spp.). La gran cantidad de fragmentos de escarabajos en las heces del mono nocturno andino podría ser debido a la composición quitinosa de sus exoesqueletos que los hace difícil de degradar. Este estudio aporta información novedosa sobre la variedad de artrópodos consumidos por el mono nocturno andino y recopila toda la información sobre el consumo de este ítem para todo el género.
Off-seasonal copulation of South American sea lion Otaria byronia in the Chilean Central Coast
Authors: Guzmán Jonathan A. , Torres Patricio , Cañón Carola , Sielfeld Walter 
Published: December 2022

El lobo marino común Otaria byronia se distribuye ampliamente en Sudamérica desde Perú pasando por Chile hasta Brasil en los océanos Pacífico y Atlántico, respectivamente. Es una especie abundante, muy vágil y sin problemas de conservación. Como todos los pinnípedos, exhibe una reproducción notablemente estacional y sincronizada con ligeras diferencias entre poblaciones, siendo una cópula atemporal el objetivo de esta nota. Durante septiembre de 2020 se realizó un censo de O. byronia en una lobera reproductiva de la costa de Chile central, cuyos individuos sobre una roca fueron observados con binoculares. Ocho individuos de Otaria byronia fueron registrados, de éstos, una pareja se cortejaba mutuamente moviendo sus cabezas, cuerpos y se desplazaban al unísono sobre la roca. Posteriormente el macho (un sub-adulto) montó a la hembra y copularon aproximadamente por 20 minutos tras lo cual, ella sin prisa salto al mar. Durante el cortejo, cópula e interacción, solo el macho emitió sonidos y no se observaron conductas agresivas mutuas, ni que la hembra se opusiera a ser copulada. Tampoco se observó que los otros individuos interactuaban con ellos. La reproducción de O. byronia ocurre durante el verano austral siendo esta cópula inusual para la temporada, sin precedentes en las poblaciones chilenas y en el subcontinente. Diversos aspectos como factores climáticos, fisiológicos o presión antropogénica se pueden sugerir como causas o detonantes de este evento. Lo anterior destaca la necesidad de ampliar los estudios en mamíferos marinos en la costa chilena, explorando el vínculo e impacto de los factores extrínsecos sobre las poblaciones.
Potential predation on the tiger rat snake Spilotes pullatus by the gray fox Urocyon cinereoargenteus
Authors: Peláez-Cruz Orlando , Mejenes-López Sol de Mayo A. , Cab-Paat Guadalupe de los Ángeles , Peralta-Castro Laura Betzálica , Marín-Quintero Manuel , Villegas Alejandro 
Published: December 2022

Los estudios sobre la dieta permiten entender las relaciones tróficas entre las comunidades bióticas. La zorra gris es un mamífero de hábitos solitarios y activo tanto de día como de noche, tiene una dieta omnívora, con hábitos alimentarios flexibles y oportunistas. La serpiente voladora es un colúbrido de actividad diurna con una amplia agilidad entre las ramas de los árboles. La zona donde se obtuvo el registro de la zorra fue en Komchén de los Pájaros, se ubica al norte del estado de Yucatán. Del 23 de diciembre de 2019 hasta el 31 de diciembre de 2021, se colocaron 8 cámaras-trampas, 6 funcionaron como estaciones independientes y 2 como una estación doble. Fueron programadas para su funcionamiento de 24 horas. El 4 de diciembre de 2021, se registró en la estación 4 a una zorra gris (Urocyon cinereoargenteus). La imagen muestra a la zorra en marcha y llevando en el hocico a una serpiente voladora (Spilotes pullatus), aunque sin evidencia de que la consumiera, lo que indica que potencialmente pudo existir dicho evento. Se han registrado pocas especies de reptiles en la dieta de U. cinereoargenteus, hasta ahora se han identificado a la iguana Iguana iguana, y la lagartija caimán norteña Gerrhonotus infernalis. Para el caso específico de S. pullatus no hay ningún registro actual. Aunque no encontramos evidencia de que la zorra gris consumiera a la serpiente, potencialmente este sería el primer registro de esta interacción.