bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iatrogenic right coronary artery occlusion during minimally invasive cardiac surgery-tricuspid annuloplasty—a case report
Authors: Urabe Daichi , Ide Masahiro , Matsuoka Motoyuki , Miyake Ryuichiro 
Published: October 2022

AbstractAlthough rare, right coronary artery (RCA) injury is a serious complication of tricuspid annuloplasty (TAP) and warrants close attention. We report a case of ST elevation myocardial infarction secondary to iatrogenic RCA occlusion during minimally invasive cardiac surgery (MICS). Electrocardiography (ECG) revealed ST segment elevation in lead II. Transesophageal echocardiography (TEE) revealed inferior wall hypokinesis after cardiopulmonary bypass, and coronary angiography revealed peripheral RCA occlusion. Intraoperatively, we detected an atrioventricular groove deformity during the second surgical procedure. Wall motion and ECG abnormalities showed normalization after TAP was reestablished. Vigilant monitoring using TEE and ECG is important to detect intraoperative myocardial ischemia during MICS-TAP.
Prevalence of different patterns of dyslipidemia in patients with type 2 diabetes in an Iranian population
Authors: Yadegar Amirhossein , Mohammadi Fatemeh , Rabizadeh Soghra , Qahremani Reihane , Esteghamati Alireza , Nakhjavani Manouchehr 
Published: October 2022

Abstract
Background
Diabetic dyslipidemia is a complex multidimensional abnormality. However, earlier studies did not focus on the prevalence of various patterns of dyslipidemia. We categorized dyslipidemia into three groups. Single dyslipidemia (7 patterns) and mixed dyslipidemia consisted of dual (16 patterns) and triple (4 patterns) combinations of different patterns of single dyslipidemia.

Methods
This cross-sectional study included 2097 patients with type 2 diabetes (T2D) between 2014 and 2021. We measured blood lipid profile parameters and calculated the atherogenic index of plasma (AIP) using log (TG/HDL-C). We analyzed dyslipidemia as a categorical variable and expressed results as numbers and percentages. We used Chi-square or Fisher exact tests to compare categorical variables.

Results
A total of 97.81% of patients had at least one lipid abnormality. High AIP (88.0%) was the most common pattern, followed by LDL-C ≥ 70mg/dl (80.1%), and low HDL-C (58.0%). 73.87% of patients had mixed dyslipidemia. The dual combination of high AIP and LDL-C ≥ 70mg/dl was the most common pattern of mixed dyslipidemia (71.1%). Additionally, 24.7% of patients had triple combination dyslipidemia. All dyslipidemia patterns were more common among women than men, except for high AIP. In patients with T2D and coronary artery disease (CAD) history, high AIP was the most prevalent pattern of dyslipidemia (87.5%), followed by LDL ≥ 70mg/dl (68.6%). Also, the dual combination of high AIP and LDL ≥ 70mg/dl was the most common pattern of mixed dyslipidemia in patients with T2D and CAD history (60.67%).

Conclusion
This study showed that single and mixed (dual and triple combination) dyslipidemia is common among patients with T2D. High AIP and LDL-C ≥ 70mg/dl were the most common patterns, either single or combined, in patients with or without CAD.
Onset of depression and anxiety among patients with gout after diagnosis: a population-based incident cohort study
Authors: Howren Alyssa , Sayre Eric C. , Choi Hyon K. , Avina-Zubieta J. Antonio , Shojania Kam , Park Jamie Y. , De Vera Mary A. 
Published: October 2022

Abstract
Background
Gout may be associated with an increased incidence of mental health disorders, however, published findings have been limited and inconsistent. Therefore, our objective was to conduct a population-based cohort study to evaluate the incidence of depression and anxiety after gout diagnosis.

Methods
We used linked population-based administrative health data in British Columbia, Canada that includes information on demographics, outpatient visits, and inpatient visits from the period of January 1, 1990 to March 31, 2018. We assessed depression and anxiety using validated International Classification of Diseases, 9th and 10th Revision coding algorithms. We applied multivariable Cox proportional hazard models to evaluate incident depression and anxiety among patients with gout in comparison to non-gout controls, adjusting for age, sex, neighbourhood income quintile, residence, comorbidities, and health care utilization.

Results
We included 157,426 incident cases of gout (60.2% male; mean age 57.1 years) and 157,426 non-gout controls (60.2% male; mean age 56.9 years). The incidence rate of depression among individuals with gout and non-gout controls was 12.9 (95% confidence interval [CI] 12.7–13.2) and 11.1 (95% CI 10.9–11.4) per 1000 person-years, respectively. The incidence rate of anxiety for those with gout was 5.4 (95% CI 5.3–5.5) per 1000 person-years and for non-gout controls was 4.6 (95% CI 4.4–4.7) per 1000 person-years. Individuals with gout had an increased onset of depression (adjusted hazard ratio [aHR], 1.08; 95% CI 1.05–1.11) and anxiety (aHR, 1.10; 95% CI 1.05–1.14) compared to non-gout controls.

Conclusion
Our population-based study shows an increased incidence of depression and anxiety following gout diagnosis in comparison to non-gout controls. Findings suggest the importance of considering psychiatric impacts in addition to the physical impacts of gout.
Novel evaluation of the expression patterns CD44 and MMP9 proteins in intracranial meningiomas and their relationship to the overall survival
Authors: Abd Elhakeem Ahmed Abd Esattar , Essa Abdelhakeem A. , Soliman Radwa Kamel , Hamdan Ali Rabee Kamel 
Published: October 2022

Abstract
Background
Meningiomas are common primary brain neoplasms. CD44 is a cell surface glycoprotein receptor that is involved in matrix-mediated cell signaling and cell–matrix adhesion. Matrix metalloproteinase-9 (MMP-9) plays important role in angiogenesis and tumor invasion. The expression of CD44 protein membranous and cytoplasmic (CD44M and CD44C) has been reported in several tumors (such as lobular carcinoma, renal cell carcinoma, sinonasal melanoma, and lymphoma) except CNS tumors.

Methods
This study addressed the expression of CD44M and CD44C and MMP9 proteins in intracranial meningiomas and their relationship to overall survival. The expression patterns of CD44M&C and MMP-9 proteins were examined in 32 cases of benign meningiomas, 12 cases of atypical meningiomas, and 6 cases of anaplastic meningiomas using immunohistochemical staining methods.

Results
There was more evidence of CD44M expression in atypical and anaplastic meningioma (p =  < 0.001). Interestingly, Spearman correlation analyses revealed significant positive correlation between CD44M and MMP9 protein (r = 0.572, p =  < 0.001) in spite of the negative correlation between MMP9 and CD44 score (r = − 0.035 p = 0.405). There was a significant association between Ki67 protein expression and the grade of meningiomas (p < 0.001) and gender (p = 0.026). There was a significant correlation between overall survival (OS) and age, gender, tumor grade, and Ki-67.

Conclusions
Extensive CD44M expression in high-grade meningioma may reflect a tendency toward more invasive power of meningioma cells into surrounding structures (dura, bone, and brain).CD44M/MMP-9 axis presented by this study is open for future investigations.
The effect of exercise on anti-Mullerian hormone levels in patients with polycystic ovary syndrome: a systematic review and meta-analysis
Authors: Kazeminia Mohsen , Rajati Fatemeh , Rajati Mojgan 
Published: October 2022

Abstract
Background
Polycystic ovary syndrome (PCOS) is considered as the most common endocrinopathy among women of childbearing age and the most important cause of anovulatory infertility. The present study aimed to estimate the pooled effect of exercise on anti-Mullerian hormone (AMH) levels in PCOS women using systematic review and meta-analysis.

Main body
The present study was conducted according to the PRISMA guidelines from 2011 to October 2021. All published studies, which met the inclusion criteria, were searched in SID, MagIran, Embase, PubMed, Scopus, Web of Science (WoS) databases, and Google Scholar motor engine using related MeSH/Emtree terms, which were combined with free text word. Finally, 12 articles were included in the meta-analysis. As a result of the combination of the studies, after exercise, AMH level in the intervention group significantly decreased up to 0.517 ± 0.169 more than that in the control group (P ˂ 0.05). The results of subgroup analysis demonstrated that the effect of resistance training for 16 weeks was higher on women with body mass index (BMI) (≥ 25 kg/m2) and AMH (≥ 10 ng/mL) before the intervention. GRADEpro software was used to grade the level of evidence.

Conclusion
This systematic review and meta-analysis showed that either strength exercise or aerobic exercise decrease the AMH level in PCOS women. It seems more duration of the exercise has a more potential advantage to reduce the AMH levels in women with PCOS. Although the results graded by very low-quality evidence, it is recommended to include exercise in the treatment programs of PCOS patients.
Angiographic patterns of coronary artery disease in young patients presenting at a tertiary cardiac center
Authors: Abdul Wajid Khan Faisal  , Ghalib Habib  , Samra Yasmin  , Waqas Latif  , Sheeraz Ahmad  
Published: October 2022

Objective: To compare the patterns of coronary artery disease (CAD) between young adults <35 years of age and patients >35 years of age.
Methods: The observational retrospective study was carried out in angiography department of emergency at Punjab Institute of Cardiology, Lahore between January 2020 and October 2020. Patients ≤35 years old were in Group-I whereas patients >35 years who served as controls were in Group-II. Patients with unstable angina, non-ST and ST elevation MI all were included. The patients with previous history of CAD (CABG/PCI) and angiography done for other purposes i.e., before valvular surgery or PPM implantation were excluded.
Results: Out of 1268 patients, 552 were in Group-I and 716 were in Group-II. The prevalence of normal coronaries/ mild CAD was higher in Group-I i.e., 224(40.6%) than in Group-II i.e., 64 (8.9%). Single vessel disease (SVD) was comparable in both the groups 185 (33.5%) vs. 216 (30.2%). Double vessel disease and triple vessel disease (TVD) was common in Group-II and left main stem (LMS) involvement was also significantly higher in Group-II i.e., 32 (4.5%) vs. 8 (1.4%). Clot in coronary arteries with or without underlying CAD was seen more frequently in Group-I, 61(11.1%) vs. 34 (4.7%). Presence of clot was seen mostly in those patients who had moderate coronary artery disease.
Conclusion: Young patients have different coronary artery disease patterns, so the management strategy must be different in this population. Majority of the young patients have non severe disease. Clot formation is commonly seen in young adults with moderate CAD.
doi: https://doi.org/10.12669/pjms.38.8.6162
How to cite this:Faisal AWK, Habib G, Yasmin S, Latif W, Ahmed S. Angiographic patterns of coronary artery disease in young patients presenting at a tertiary cardiac center. Pak J Med Sci. 2022;38(8):---------. doi: https://doi.org/10.12669/pjms.38.8.6162
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Κόποις» ή «copies»; Μαθητικές/ φοιτητικές αφηγήσεις και κοινωνική ποιητική
Authors: Benincasa Luciana 
Published: October 2022

Adopting a voluntaristic approach, this paper aims to highlight the creativity of social actors. My objectives are (a) to examine examples of the dominant meritocratic narrative in students’ interview discourse and (b) to present an example of the way in this same narrative is challenged by other student narratives. I use two types of data from student culture: (a) excerpts from newspaper interviews with students, referred to as the “first of the first”, who were admitted with the highest marks to very prestigious university departments and (b) a well-known student saying about achievement. The students’ interview discourse resounds with the ideology of effort, described as the road to success and endorsed by educational and political authorities alike. The saying in question, on the other hand, proposes a very different narrative, according to which success is the result of cheating. More than being just different, this alternative narrative openly questions and even ridicules official narratives and the ideology that backs them. This is discussed as an aspect of “social poetics” (Herzfeld).
Η Αισθητική – Καλλιτεχνική Εκπαίδευση στην ευρύτερη Νησιωτική Περιοχή της Δωδεκανήσου
Authors: Καμπουροπούλου Μαίρη 
Published: October 2022

The dialectical relationship between the traditional and the contemporary, which surrounds every human expression, is the dominant feature of both art and architecture, as manifested in practice and theory and is the subject of this study. The aim is to search, investigate through all the elements that coexist in traditional and modern environment, those constants that can seem beneficial in interpretation, in experiencing and recreating the Greek island tradition.
A child who is going to be an islander, a tomorrow's citizens learns to be inspired by the cultural heritage seeking to offer to the society through rebuilding, changing and adaptation that will stem from the historical validity, modern trends and expressed improvement and progress. The reciprocal relationship between traditional and modern art provides to a child a holistic approach to the environment, giving impulses of high quality in different areas, such as History, Architecture, Folklore, Literature, Culture in producing quality goods. The global approach of an aesthetic education that begins in early childhood is one of the sectors that can effectively help in this direction: awareness of the need for maintenance and upgrading of tradition with a view to productive coupling of traditional with modern.
Εκπαίδευση Ενηλίκων: Ο κριτικός στοχασμός σε ένα σύγχρονο μοντέλο μάθησης
Authors: Παπαχρήστου Μαρία 
Published: October 2022

Σε αυτή τη μελέτη, βασικός μας στόχος είναι να ορίσουμε με σαφήνεια τον όρο «κριτικός στοχασμός», αλλά και να προσδιορίσουμε την σημασία της έννοιας αυτής μέσα στο πεδίο της Εκπαίδευσης Ενηλίκων. Στη σύγχρονη εποχή, η Εκπαίδευση Ενηλίκων συνιστά ένα ιδιαίτερο μοντέλο μάθησης το οποίο σηματοδοτεί ένα νέο παιδαγωγικό πλαίσιο, έξω από την παραδοσιακή εκπαίδευση, άμεσα συνδεδεμένο με την οικονομική ανάπτυξη και την κοινωνική ευημερία. Κομβικό ρόλο στην υπόθεση του «κριτικού στοχασμού» αποτελεί η παρουσία της εμπειρίας. Επομένως, θα πρέπει να αναδείξουμε τον τρόπο με τον οποίο το στοιχείο της εμπειρίας καθορίζει τον μηχανισμό προσέγγισης της γνώσης, πώς αυτή η γνώση, στη συνέχεια, μετασχηματίζει την πραγματικότητα σε υποκειμενική, ανατροφοδοτούμενη και μεταλλασσόμενη αλήθεια. Για το σκοπό αυτό θα παρουσιάσουμε και θα αναλύσουμε τις κυριότερες βιβλιογραφικές πηγές και αναφορές οι οποίες, σε ένα πρώτο επίπεδο θα μας εξοικειώσουν με τις σύγχρονες παιδαγωγικές αντιλήψεις και σε ένα δεύτερο επίπεδο, θα μας βοηθήσουν να συλλάβουμε το πώς ο άνθρωπος, μέσα από τους σύγχρονους παιδαγωγικούς μηχανισμούς που εισάγει η Εκπαίδευση Ενηλίκων, οδηγείται να επανεφεύρει τον εαυτό του και να επαναπροσδιορίσει τη σχέση του και τη γνώση του για το περιβάλλον που τον περικλείει.
Smart city perspectives in post-pandemic governance: Externalities reduction policy
Authors: Vladimirovna Kalinina Olga , Evgenievich Barykin Sergey , Mikhailovich Sergeev Sergey , NikolaevnaSemenova Galina , Fatkullina Alina , Mikhaylov Alexey , De La Poza Plaza Elena 
Published: October 2022

Background: The ongoing COVID-19 quarantine restrictions have caused multiple sharp decreases in activities associated with the movement of large masses of people. The economies of regions and cities that are critically dependent on tourist flows related to various segments have suffered. This research aims to provide an economic-mathematical model of smart cities externalities’ impact from the point of view of achieving social and environmental goals Methods: The objective of this study was to develop an algorithm for supporting decision-makers. Methods of mathematical modeling, statistical processing of data received in real-time, as well as methods for finding solutions by expansion into dynamic series are used, and the theory of mathematical games is applied. The theoretical mathematical model presented considers the statistical processing of data provided in real time referring to the performance indicators of megacities. Results: The activities of administrations and governments aimed at maintaining stability over the past two years have been aimed at reducing the negative impact of the pandemic. The prospect of returning to normal conditions is complicated by a number of factors. The proposed approach allows the development of the fundamental basis for making administrative decisions within individual megapolises and in environmental policy on a territory of any scale. The developed mathematical model is abstract by definition and is applied by taking into account specific tasks and criteria. Since the tasks of the administration differ depending on the region and country, the choice of criteria is set individually. Conclusions: During the period of isolation, the volume of services in the Hotel - Restaurant- Catering/Café (HORECA) segment has decreased, and personnel has also been lost. The reduced pressure on public infrastructure and the departure of migrants means that, in the long term, this work cannot be restored within a short period of time.
Evaluation of patients’ satisfaction with bronchoscopy procedure
Authors: Karewicz Aleksandra , Faber Katarzyna , Karon Katarzyna , Januszewska Katarzyna , Ryl Joanna , Korczynski Piotr , Gorska Katarzyna , Dabrowska Marta , Krenke Rafal 
Published: October 2022

BackgroundThe bronchoscopy (BS) experience provokes anxiety amongst some patients. It can have a negative impact on the course of the procedure and on the willingness of patients to undergo the next BS in the future.ObjectiveWe aimed to identify factors influencing patients’ satisfaction with BS.MethodsThe prospective study had been conducted between January and June 2019. It included patients hospitalized in our Department, who underwent elective BS. Patients assessed their anxiety and satisfaction level before and after BS using the Visual Analogue Scale (VAS). Data concerning the course of the bronchoscopy was collected.ResultsThe median level of anxiety prior to the procedure was moderate, higher in women (p<0.0001). The majority of patients (116/125, 93%) were satisfied with appropriate information before the procedure. Almost one-third of the interviewees (39/125, 31%) declared complete satisfaction (VAS = 0) with their procedure, 17 patients (14%) were dissatisfied (VAS >5/10). Overall 113 (90%) patients declared unconditional consent for future bronchoscopy. Multivariate linear regression analysis revealed two factors affecting patients’ satisfaction with bronchoscopy: anxiety prior to BS (standardized regression coefficient β = 0.264, p = 0.003) and discomfort (β = 0.205, p = 0.018). Neither age, degree of amnesia, duration of the procedure nor its type added any significant value as factors affecting patient satisfaction. The most common factors inducing patients’ discomfort during BS were local anesthesia of the throat (56/125, 45%) and cough (47/125, 38%).ConclusionsLow anxiety level before bronchoscopy and reduced discomfort during the procedure are associated with better patient satisfaction. Thus, it is important to reduce patient anxiety and discomfort during the procedure.
Limited value of neutrophil-to-lymphocyte ratio and serum creatinine as point-of-care biomarkers of disease severity and infection mortality in patients hospitalized with COVID-19
Authors: Tufa Abdisa , Gebremariam Tewodros Haile , Manyazewal Tsegahun , Asrat Yidnekachew , Getinet Tewodros , Hundie Tsegaye Gebreyes , Webb Dominic-Luc , Hellström Per M. , Genet Solomon 
Published: October 2022

IntroductionIn hospitalized COVID-19, neutrophil-to-lymphocyte ratio (NLR) and serum creatinine is sometimes measured under assumption they predict disease severity and mortality. We determined the potential value of NLR and serum creatinine as predictors of disease severity and mortality in COVID-19.MethodsProspective cohort study of COVID-19 patients admitted to premier COVID-19 treatment hospitals in Ethiopia. Predictive capability of biomarkers in progression and prognosis of COVID-19 was analyzed using receiver operating characteristics. Survival of COVID-19 patients with different biomarker levels was computed. Logistic regression assessed associations between disease severity and mortality on NLR and serum creatinine adjusted for odds ratio (AOR).ResultsThe study enrolled 126 adults with severe (n = 68) or mild/moderate (n = 58) COVID-19, with median age 50 [interquartile range (IQR 20–86)]; 57.1% males. The NLR value was significantly higher in severe cases [6.68 (IQR 3.03–12.21)] compared to the mild/moderate [3.23 (IQR 2.09–5.39)], with the NLR value markedly associated with disease severity (p<0.001). Mortality was higher in severe cases [13 (19.1%)] compared to mild/moderate cases [2 (3.4%)] (p = 0.007). The NLR value was significantly higher in non-survivors [15.17 (IQR 5.13–22.5)] compared to survivors [4.26 (IQR 2.40–7.90)] (p = 0.002). Serum creatinine was significantly elevated in severe cases [34 (50%)] compared with mild/moderate [11 (19%)] (p<0.001). Disease severity [AOR 6.58, 95%CI (1.29–33.56),p = 0.023] and NLR [AOR 1.07, 95%CI (1.02–1.12),p = 0.004)] might be associated with death. NLR had a sensitivity and specificity of 69.1% and 60.3% as predictor of disease severity (cut-off >4.08), and 86.7% and 55.9% as prognostic marker of mortality (cut-off >4.63).ConclusionIn COVID-19, NLR is a biomarker with only modest accuracy for predicting disease severity and mortality. Still, patients with NLR >4.63 are more likely to die. Monitoring of this biomarker at the earliest stage of the disease may predict outcome. Additionally, high creatinine seems related to disease severity and mortality.
The patterns of uveitis and the factors affecting visual outcome from Chulalongkorn University Uveitis Cohort (CU2C): A 5-year longitudinal study protocol
Authors: Juhong Jakkrit , Pongpirul Krit , Ueathaweephol Somtaporn , Somkijrungroj Thanapong , Kongwattananon Wijak 
Published: October 2022

Background
In Thailand, several novel laboratory investigations are recently available to help differentiate the uveitic etiologies. The update on uveitis epidemiological data in Thailand is necessary to better understand the disease burden and provide guidance on management. The current study aims to describe the prevalence and identify factors associated with poor visual outcomes of uveitis patients at a tertiary center in Thailand.

Methods
A 5-year-prospective study of uveitis cases presented at a tertiary referral center in the central region of Thailand is conducted.