bluuebunny/crossref_metadata_2025_split huggingface dataset:
« Se mesler avec les bestes brutes »La bestialité dans la littérature des XVIe-XVIIe siècles
Authors: Holtz Grégoire 
Published: March 2022

Résumé
L’objet de cet article est d’analyser les récits de bestialité qui se multiplient dans la littérature des XVIe et XVIIe siècles, dans les écrits juridiques, médicaux, polémiques et surtout dans les relations de voyages. Ces anecdotes qui mettent en scène des accouplements, voire des enfantements, entre hommes et bêtes, amènent à questionner les rapports troubles entre l’épistémè de la Renaissance et les savoirs ethnographiques acquis durant cette première époque coloniale, savoirs qui s’imprègnent parfois des récits mythologiques locaux. Inspirées par une perspective anthropomorphique comme par le modèle de la fable, ces anecdotes zoophiles témoignent de la diversité des réflexions sur un possible interrègne, sur les zones de partage instables entre l’homme et l’animal, mais aussi sur la projection de stéréotypes animaliers sur des populations étrangères.
Le zoophyte comme limite du merveilleux naturel à la RenaissanceLe cas des conches anatifères
Authors: Vignaud Laurent-Henri 
Published: March 2022

Résumé
Les zoophytes, étranges êtres mi-animaux mi-végétaux, fascinent les naturalistes depuis l’Antiquité. Ces hybrides sont généralement conçus comme des êtres intermédiaires qui rendent sensible la continuité naturelle à travers l’échelle du vivant. Mais quand il s’agit des « conches anatifères », des coquillages écossais que l’on dit naître du bois pourri et engendrer des oiseaux (les bernaches), le savoir naturaliste de la Renaissance atteint ses limites. Les érudits discutent de la possibilité du phénomène en reconsidérant les théories de la génération spontanée et en enquêtant sur ces merveilleux coquillages présents dans certains cabinets de curiosités. Remise en cause, la légende s’envole un peu plus loin, jusqu’en Chine, pour survivre à l’examen critique.
On the Map: Feminist Political Ethnography in Gendered Citizenship
Authors: Beard Lisa 
Published: March 2022

Abstract
In Gendered Citizenship: Understanding Gendered Violence in Democratic India, Natasha Behl explores the gap between the promise of gender equality enshrined in the Indian Constitution and contemporary patterns of sexual and gendered-based violence and discrimination in democratic India. This essay explores the political ideas, meaning making, and the interplay of state and civilian discourses undergirding forms of gendered violence illuminated by Behl’s feminist and interpretive approach. The essay closes by tracing two themes for further inquiry—feminist geographies and political openings/closures—and offers some preliminary engagement.
Multiscale Processes of Heavy Rainfall over East Asia in Summer 2020: Diurnal Cycle in Response to Synoptic Disturbances
Authors: Zeng Wenxin , Chen Guixing , Bai Lanqiang , Liu Qian , Wen Zhiping 
Published: March 2022

Abstract
Multiscale processes from synoptic disturbances to diurnal cycles during the record-breaking heavy rainfall in summer 2020 were examined in this study. The heavy rainfall consisted of eight episodes, each lasting about 5 days, and were associated with two types of synoptic disturbances. The Type-1 episodes featured a northwestward extending western Pacific subtropical high (WPSH), while the Type-2 episodes had approaching midlatitude troughs with southward retreat in the WPSH. Each heavy rainfall episode had 2–3 occurrences of nocturnal low-level jets (NLLJs), in close association with intense rainfall in the early morning. The NLLJs formed partly due to the geostrophic wind by increased pressure gradients under both types of synoptic disturbances. The NLLJs were also driven by the ageostrophic wind that veered to maximum southerlies at late night due to the boundary-layer inertial oscillation. The diurnal amplitudes of low-level southerlies increased remarkably after the onset of Type-1 episodes, in which the extending WPSH provided strong daytime heating from solar radiation. By contrast, the wind diurnal amplitudes were less changed after the onset of Type-2 episodes. The NLLJs strengthened the mesoscale mean ascent, net moisture flux convergence, and convective instability in elevated warm moist air, which led to the upscale growth of MCSs at the northern terminus of the LLJ after midnight. The MCSs-induced Meiyu rainband was re-established in Central China during the Type-1 episodes with the increased diurnal variations. The findings highlight that the regional diurnal cycles of low-level winds in response to synoptic disturbances can strongly regulate mesoscale convective activities in a downscaling manner, and thus produce heavy rainfall.
Factors Associated With Resistance to In-Hospital Treatment of Malaria in Angolan Patients
Authors: Sacomboio Euclides Nenga Manuel , S Sebastião Cruz , Antonio Jurema Luzia Francisco , Vezo Álvaro Kuanzambi , Bapolo Daisy Viviana Sebastião , Morais Joana 
Published: March 2022

Background: Malaria is a public health problem, particularly in low- and middle-income countries. In Angola, it is the leading cause of death, morbidity, and absenteeism from work and school. Objective: To evaluate the social and clinical factors associated with resistance to in-hospital treatment. Methodology: A prospective analytical cross-sectional study with a quantitative approach was conducted including 220 patients with malaria. Results: Of the 220 patients enrolled, the majority were between 21 and 40 years old (72.7%), male (53.6%), of peri-urban areas (47.7%), employees (46.4%), and with high parasitemia levels (57.7%). Of the remaining hospitalized patients (61.4%), 20.9% were resistant to treatment. The resistance risk was higher in patients over 40 years [OR: 5.91 (95% CI: 0.76-45.7), P = .088], from rural regions [OR: 2.48 (95% CI: 0.95-6.48), P = .064], that were unemployed [OR: 1.06 (95% CI: 0.52-2.15), P = .859], presenting high parasitemia [OR: 1.95 (95% CI: 1.02-3.75), P = .043] and who remained hospitalized [OR: 5.28 (95% CI: 0.63-43.1), P = .121]. The risk to develop resistance was lower in patients that were students [OR: 0.04 (95% CI: 0.01-0.37), P = .004], patients who were treated with dipyrone [OR: 0.06 (95% CI: 0.01-0.24), P < .001], metoclopramide [OR: 0.25 (95% CI: 0.09-0.67), P = .006] and ciprofloxacin [OR: 0.22 (95% CI: 0.11-0.44), P < .001]. Conclusion: Treatment with antimalarial drugs as well as the use of adjuvants such as dipyrone, metoclopramide, ciprofloxacin, and diazepam can reduce the chances of developing resistance to malaria treatment, however, it is necessary to carry out further in-depth studies.
The new mineral zolotarevite, Na5Zr[Si6O15(ОН)3]⋅2–3H2O, the first highly hydrated lovozerite-group member from the Lovozero alkaline massif, Kola Peninsula, Russia
Authors: Mikhailova Julia A. , Selivanova Ekaterina A. , Krivovichev Sergey V. , Pakhomovsky Yakov A. , Chukanov Nikita V. , Yakovenchuk Victor N. 
Published: March 2022

AbstractZolotarevite (IMA2020-076), ideally Na5Zr[Si6O15(ОН)3]⋅2–3H2O, is а new mineral of the lovozerite group. The mineral was found in a leucocratic nepheline syenite from Kedykverpakhk Mt., Lovozero alkaline massif, Kola Peninsula, Russia. It occurs as anhedral grains up to 1 mm across and is associated with microcline–perthite, nepheline, sodalite, aegirine, lamprophyllite, lueshite, umbozerite, lomonosovite, nastrophite, a mineral of the kazakovite–tisinalite series, sphalerite and löllingite. Zolotarevite is cherry red, with a vitreous lustre and white streak. The mineral is brittle, with a Mohs hardness of 5. Cleavage was not observed; the fracture is uneven. The measured density is 2.75(5) g⋅cm–3, the density calculated using the empirical formula and single-crystal unit-cell parameters is 2.85 g⋅cm–3. Zolotarevite is anomalously biaxial (–), α = 1.580(2), β = 1.600(2) and γ = 1.602(2) (for λ = 589 nm); 2Vmeas < 10°. Chemical data (electron microprobe, wt.%) are: Na2O 20.41, СаО 0.42, MnO 3.49, Fе2O3 0.55, SiO2 52.46, ТiO2 1.34, ZrO2 11.33, H2O (calculated from the structural formula) 10.20, total 100.20. The empirical formula based оn 6 Si atoms per formula unit is Na4.53Zr0.63Mn0.34Ti0.11Ca0.05Fe3+0.05Si6O14.43(ОН)3.56(H2О)2.11. Zolotarevite is trigonal, space group R${\bar 3}$m, with a = 10.294(6) Å, c = 13.115(8) Å, V = 1203.7(16) Å3 and Z = 3. The crystal structure was solved from single-crystal data and refined to R1 = 0.049. The strongest lines of the powder X-ray diffraction pattern [d in Å (I) (hkl)] are: 7.37 (69) (101); 5.26 (56) (012); 3.686 (64) (202); 3.330 (79) (113); 3.265 (99) (211), 2.640 (100) (024) and 2.576 (60) (220). Zolotarevite is unique in that it is a highly hydrated lovozerite-group mineral with the B site occupied by variable amounts of H2O.
3D electron diffraction study of terrestrial iron oxide alteration in the Mineo pallasite
Authors: Mugnaioli Enrico , Zucchini Azzurra , Comodi Paola , Frondini Francesco , Bartolucci Luca , Di Michele Alessandro , Sassi Paola , Gemmi Mauro 
Published: March 2022

AbstractThe Mineo pallasite is a relatively poorly known meteorite, which shows interesting features that are not fully understood, such as the occurrence of iron oxide regions bordering both the olivine grain boundaries and the (Fe,Ni) metal. In this study, the Fe oxides have been characterised by Raman spectroscopy, electron microprobe analysis, field emission scanning electron microscopy, transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS) and 3D electron diffraction (3D ED). The combination of TEM–EDS and 3D ED yields a reliable identification of the chemical and crystallographic features of the cryptocrystalline portion of the sample investigated, enabling the Fe-oxide regions to be positively identified as goethite, FeO(OH).The occurrence of goethite was unambiguously associated with terrestrial alteration, also confirmed by the presence of calcite, detected by TEM-EDS and 3D ED. Goethite contains minor elements such as Na, Si and Ca, probably coming from alumino-silicates in the terrestrial environment, and Ni associated with the (Fe,Ni) metal. The observation of goethite along olivine grain boundaries, as an alteration product of the (Fe,Ni) metal diagenesis, is also very intriguing as it might be related to the (Fe,Ni) metal intruded into the sub-micrometric olivine fragments during pallasite formation. Further work is needed to extensively analyse the texture and composition of olivine/metal boundaries.
Mammary epithelial cell transcriptome reveals potential roles of lncRNAs in regulating milk synthesis pathways in Jersey and Kashmiri cattle
Authors: Mumtaz Peerzada Tajamul , Bhat Basharat , Ibeagha-Awemu Eveline M. , Taban Qamar , Wang Mengqi , Dar Mashooq Ahmad , Bhat Shakil Ahmad , Shabir Nadeem , Shah Riaz Ahmad , Ganie Nazir A. , Velayutham Dinesh , Haq Zulfqar ul , Ahmad Syed Mudasir 
Published: March 2022

Abstract
Background
Long noncoding RNAs (lncRNAs) are now proven as essential regulatory elements, playing diverse roles in many biological processes including mammary gland development. However, little is known about their roles in the bovine lactation process.

Results
To identify and characterize the roles of lncRNAs in bovine lactation, high throughput RNA sequencing data from Jersey (high milk yield producer), and Kashmiri cattle (low milk yield producer) were utilized. Transcriptome data from three Kashmiri and three Jersey cattle throughout their lactation stages were utilized for differential expression analysis. At each stage (early, mid and late) three samples were taken from each breed. A total of 45 differentially expressed lncRNAs were identified between the three stages of lactation. The differentially expressed lncRNAs were found co-expressed with genes involved in the milk synthesis processes such as GPAM, LPL, and ABCG2 indicating their potential regulatory effects on milk quality genes. KEGG pathways analysis of potential cis and trans target genes of differentially expressed lncRNAs indicated that 27 and 48 pathways were significantly enriched between the three stages of lactation in Kashmiri and Jersey respectively, including mTOR signaling, PI3K-Akt signaling, and RAP1 signaling pathways. These pathways are known to play key roles in lactation biology and mammary gland development.

Conclusions
Expression profiles of lncRNAs across different lactation stages in Jersey and Kashmiri cattle provide a valuable resource for the study of the regulatory mechanisms involved in the lactation process as well as facilitate understanding of the role of lncRNAs in bovine lactation biology.
Posttraumatic midazolam administration does not influence brain damage after experimental traumatic brain injury
Authors: Sebastiani Anne , Bender Simone , Schäfer Michael K. E. , Thal Serge C. 
Published: March 2022

Abstract
Background
The benzodiazepine midazolam is a γ-aminobutyric acid (GABA)-A receptor agonist frequently used for sedation or stress control in patients suffering from traumatic brain injury (TBI). However, experimental studies on benzodiazepines have reported divergent results, raising concerns about its widespread use in patients. Some studies indicate that benzodiazepine-mediated potentiation of GABAergic neurotransmission is detrimental in brain-injured animals. However, other experimental investigations demonstrate neuroprotective effects, especially in pretreatment paradigms. This study investigated whether single-bolus midazolam administration influences secondary brain damage post-TBI.

Methods
Two different midazolam dosages (0.5 and 5 mg/kg BW), a combination of midazolam and its competitive antagonist flumazenil, or vehicle solution (NaCl 0.9%) was injected intravenously to mice 24 h after experimental TBI induced by controlled cortical impact. Mice were evaluated for neurological and motor deficits using a 15-point neuroscore and the rotarod test. Histopathological brain damage and mRNA expression of inflammatory marker genes were analyzed using quantitative polymerase chain reaction three days after insult.

Results
Histological brain damage was not affected by posttraumatic midazolam administration. Midazolam impaired functional recovery, and this effect could not be counteracted by administering the midazolam antagonist flumazenil. An increase in IL-1β mRNA levels due to postinjury application of midazolam was reversible by flumazenil administration. However, other inflammatory parameters were not affected.

Conclusions
This study merely reports minor effects of a postinjury midazolam application. Further studies focusing on a time-dependent analysis of posttraumatic benzodiazepine administration are required.
Circulating long non-coding RNA TTTY15 and HULC serve as potential novel biomarkers for predicting acute myocardial infarction
Authors: Xie Jiajia , Liao Wenjun , Chen Wuqi , Lai Disheng , Tang Qidong , Li Yuhui 
Published: March 2022

Abstract
Introduction
Acute myocardial infarction (AMI) is a ubiquitous cardiovascular disease ensuing adverse prognosis caused by myocardial necrosis. Effective and rapid diagnosis of AMI is essential to following treatment in clinical practice while the existed biomarkers have inherent limitations. Consequently, exploration of novel biomarkers is needed. Long noncoding RNA (lncRNA) emerges as the upcoming biomarkers adopted in clinical use, and we aim at investigating the diagnostic power of lncRNA TTTY15 and HULC in AMI patients.

Method
We measured lncRNA level in 80 AMI patients and 36 healthy volunteers in discovering cohort and 50 AMI patients and 20 healthy volunteers in verification cohort with quantitative RT-PCR method. Receiver operating characteristic (ROC) analysis was administered to detect the diagnostic power of selected lncRNAs. Regression and correlation analyses were performed to explore the related factors.

Results
ROC analysis reveals the superiority of TTTY15 and HULC as biomarkers against conventional AMI biomarkers CKMB (AUC of TTTY15: 0.915 versus CKMB: 0.768 versus TnT: 0.869); AUC of HULC: 0.905 versus CKMB: 0.768 versus TnT: 0.869). Regression and correlation analysis indicates that TTTY15 and HULC may be one of the contributing factors to AMI and related to accepted risk factors.

Conclusion
Our results revealed the diagnostic potency of lncRNA TTTY15 and HULC, and they could also be treated as novel therapeutic targets in AMI therapy, hinting inspiration to the cardiologist in clinical practice.
Protein-losing gastroenteropathy complicated with asymptomatic primary biliary cholangitis, refractory to immunosuppressant, and improved by Helicobacter pylori eradication: a case report
Authors: Tanaka Misako , Kawaratani Hideto , Noguchi Ryuichi , Koizumi Aritoshi , Shibamoto Akihiko , Kaji Kosuke , Shimozato Naotaka , Kojima Kuniyuki , Nishimura Yoshiaki , Yoshiji Hitoshi 
Published: March 2022

Abstract
Background
Protein-losing gastroenteropathy (PLGE) is a syndrome with a chief complaint of hypoalbuminemia, which occurs due to plasma protein leakage in the gastrointestinal tract, leading to general edema, ascites, and pleural effusions.

Case presentation
A 71-year-old woman visited another hospital for evaluation of hypoalbuminemia and systemic edema. She was hospitalized for a close inspection of hypoalbuminemia and was diagnosed with PLGE. Steroid and azathioprine therapy was prescribed; however, hypoalbuminemia did not improve, and the patient’s condition worsened due to anasarca. As hospitalization was prolonged, the patient was transferred to our hospital. She was infected with Helicobacter pylori, and we performed H. pylori eradication. Following H. pylori eradication, her edema improved remarkably.

Conclusion
We present the first case wherein H. pylori eradication successfully improved protein leakage in the lower gastrointestinal tract in a patient diagnosed with PLGE complicated with refractory to immunosuppressant treatment. H. pylori eradication should be considered in patients with PLGE complicated with H. pylori infection, without specific endoscopic finding or refractory to immunosuppressants.
A rare presentation of blastomycosis as a multi-focal infection involving the spine, pleura, lungs, and psoas muscles in a Saudi male patient: a case report
Authors: Eldaabossi Safwat , Saad Mustafa , Aljawad Hameed , Almuhainy Badr 
Published: March 2022

Abstract
Background
Blastomycosis is a disease caused by the fungus Blastomyces—a thermally dimorphic fungus that can cause granulomatous and/or purulent infection.

Case presentation
We report here a case of chronic blastomycosis infection in a 24-year-old male patient from Saudi Arabia who presented with recurrent skin abscesses associated with deep-seated and multilevel paraspinal (dorsal and lumbar) collections and bilateral empyema with pulmonary involvement and bilateral psoas abscesses. The diagnosis was made after a CT-guided pleural biopsy revealed the characteristic histopathological findings of blastomycosis. The patient underwent several drainage procedures and was successfully treated with a long-term course of oral itraconazole.

Conclusions
Chronic blastomycosis may have clinical and radiologic features similar to thoracic tuberculosis or malignant disease. There is no definite clinical symptom of blastomycosis, and thus a high degree of suspicion is required for early diagnosis. This case is a rare form of blastomycosis with chronic multifocal purulent infection and is the second case of blastomycosis reported in Saudi Arabia.
miR-543 regulates high glucose-induced fibrosis and autophagy in diabetic nephropathy by targeting TSPAN8
Authors: Zhuang Langen , Ge Xiaoxu , Hu Xiaolei , Yang Qingqing , Pei Xiaoyan , Jin Guoxi 
Published: March 2022

Abstract
Background
Diabetic nephropathy (DN) is one of the most common and serious complications of diabetes, which can lead to renal failure and fatality. miRNAs are an important class of endogenous non-coding RNAs implicated in a wide range of biological processes and pathological conditions. This study aims to investigate the potential functional roles of miR-543 in DN and its underlying mechanisms.

Methods
qRT-PCR was performed to detect the expression levels of miR-543 and TSPAN8 in kidney tissues of mice with DN. Western blot (WB) was used to measure the protein levels. CCK8 assay was employed to evaluate the proliferation of HK2 cells. Dual luciferase reporter assay was conducted to verify the functional interaction between miR-543 and TSpan8.

Results
The downregulation of miR-543 and upregulation of TSPAN8 were observed in kidney tissues of mice with DN. miR-543 mimic significantly decreased cell proliferation and autophagy in high-glucose (HG)-induced HK2 cells, and promoted cell fibrosis. We further identified a putative binding site between miR-543 and TSPAN8, which was validated by Dual luciferase reporter assay. The treatment of miR-543 mimic and miR-543 inhibitor could reduce or increase TSPAN8 protein level respectively. We further showed that the overexpression of TSPAN8 could attenuate HG-induced cell injury by reducing fibrosis and increase autophagy. The effects of miR-543 mimic in proliferation, fibrosis, and autophagy were rescued by TSPAN8 overexpression.

Conclusions
Our study indicate that miR-543 mediates high-glucose induced DN via targeting TSPAN8. Interfering miR-543/TSPAN8 axis could serve as potential approach to ameliorate DN.
Exploring why patients in heroin-assisted treatment are getting incarcerated—a qualitative study
Authors: Meyer Maximilian , Rist Bernd , Strasser Johannes , Lang Undine E. , Vogel Marc , Dürsteler Kenneth M. , Walter Marc 
Published: March 2022

Abstract
Background
Heroin-assisted treatment has proven effective in reducing criminal offenses in opioid dependent individuals. Few studies attempted to explain the observed crime reduction and the reasons why these patients keep offending and getting incarcerated have to date not been explored.

Methods
Patients with a history of incarcerations during the time of participating in heroin-assisted treatment (n = 22) were invited to a semi-structured, narrative interview. Findings were evaluated with Mayring’s qualitative content analysis framework. Additionally, the Montreal Cognitive Assessment test and the multiple-choice vocabulary intelligence test used to assess cognitive impairment and premorbid intelligence levels.

Results
Three main categories emerged in patients’ narratives on their incarcerations: cocaine use, impaired functioning, and financial constraints. Lifetime prevalence of cocaine use disorder was 95.5% and their cocaine use often led to patients getting incarcerated. Impaired functioning mainly constituted the inability to receive and open mail. Financial constraints led to incarcerations in lieu of payment in 16 participants (72.7%). Categories overlapped notably and often occurred in close temporal proximity. A fourth category on the likelihood of getting incarcerated again in the future was inhomogeneous and ranged from the strong conviction to complete rejection of the scenario. Average premorbid intelligence levels were found, whereas the cognitive assessment suggested severe cognitive impairment in our sample.

Conclusion
Participants mainly reported to have committed minor offenses and not being able to pay for resulting fines. The resulting prison sentences are an unconvincing practice from a medical and economic perspective alike. Public expenditure and the interruptions of the continuum of care could be reduced by legislatively protecting these marginalised patients.