bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burden of Rare Genetic Variants in Spontaneous Coronary Artery Dissection With High-risk Features
Authors: Wang Yu , Starovoytov Andrew , Murad Andrea M. , Hunker Kristina L. , Brunham Liam R. , Li Jun Z. , Saw Jacqueline , Ganesh Santhi K. 
Published: September 2022

ImportanceThe emerging genetic basis of spontaneous coronary artery dissection (SCAD) has been defined as both partially complex and monogenic in some patients, involving variants predominantly in genes known to underlie vascular connective tissue diseases (CTDs). The effect of these genetic influences has not been defined in high-risk SCAD phenotypes, and the identification of a high-risk subgroup of individuals may help to guide clinical genetic evaluations of SCAD.ObjectiveTo identify and quantify the burden of rare genetic variation in individuals with SCAD with high-risk clinical features.Design, Setting, and ParticipantsWhole-exome sequencing (WES) was performed for subsequent case-control association analyses and individual variant annotation among individuals with high-risk SCAD. Genetic variants were annotated for pathogenicity by in-silico analysis of genes previously defined by sequencing for vascular CTDs and/or SCAD, as well as genes prioritized by genome-wide association study (GWAS) and colocalization of arterial expression quantitative trait loci. Unbiased genome-wide association analysis of the WES data was performed by comparing aggregated variants in individuals with SCAD to healthy matched controls or the Genome Aggregation Database (gnomAD). This study was conducted at a tertiary care center. Individuals in the Canadian SCAD Registry genetics study with a high-risk SCAD phenotype were selected and defined as peripartum SCAD, recurrent SCAD, or SCAD in an individual with family history of arteriopathy.Main Outcomes and MeasuresBurden of genetic variants defined by DNA sequencing in individuals with high-risk SCAD.ResultsThis study included a total of 336 participants (mean [SD] age, 53.0 [9.5] years; 301 female participants [90%]). Variants in vascular CTD genes were identified in 17.0% of individuals (16 of 94) with high-risk SCAD and were enriched (OR, 2.6; 95% CI, 1.6-4.2; P = 7.8 × 10−4) as compared with gnomAD, with leading significant signals in COL3A1 (OR, 13.4; 95% CI, 4.9-36.2; P = 2.8 × 10−4) and Loeys-Dietz syndrome genes (OR, 7.9; 95% CI, 2.9-21.2; P = 2.0 × 10−3). Variants in GWAS-prioritized genes, observed in 6.4% of individuals (6 of 94) with high-risk SCAD, were also enriched (OR, 3.6; 95% CI, 1.6-8.2; P = 7.4 × 10−3). Variants annotated as likely pathogenic or pathogenic occurred in 4 individuals, in the COL3A1, TGFBR2, and ADAMTSL4 genes. Genome-wide aggregated variant testing identified novel associations with peripartum SCAD.Conclusions and RelevanceIn this genetic study, approximately 1 in 5 individuals with a high-risk SCAD phenotype harbored a rare genetic variant in genes currently implicated for SCAD. Genetic screening in this subgroup of individuals presenting with SCAD may be considered.
Same-Day Home Recovery for Benign Foregut Surgery
Authors: Teh Swee H. , Schecter Samuel C. , Servais Edgar B. , Liu Kingsway , Svahn Jonathan , Yang Lisa , Goodstein Monica , Parent Richard , Chau Edward , Chang Lynn , Zhou Minhoa , Shiraga Sharon , Knox Michelle 
Published: September 2022

ImportanceSame-day home recovery (SHR) is now the standard of care for many major surgical procedures and has the potential to become standard practice for benign foregut procedures (eg, hiatal hernia repair, fundoplication, and Heller myotomy).ObjectiveTo determine whether SHR for patients undergoing benign foregut surgery is feasible, safe, and effective.Design, Setting, and ParticipantsThis prospective cohort study took place across 19 medical centers within an integrated health care system in northern California from January 2019 through September 2021. Participants included consecutive patients undergoing elective benign foregut surgery.ExposuresStandardized SHR program.Main Outcomes and MeasuresThe primary end point was the rate of SHR. The secondary end points were 7-day and 30-day rates of postoperative emergency department visits, hospital readmissions, and reoperations.ResultsOf 1248 patients who underwent benign foregut surgery from January 2017 through September 2021, 558 were patients before implementation of the SHR program and 690 were patients postimplementation. The mean age of patients was 60 years, and 759 (59%) were female. The preimplementation SHR rate was 64 of 558 patients (11.5%) in 2018 and increased to 82 of 113 patients (72.6%) by 2021 (94/350 [26.9%] in 2019 and 112/227 [49.3%] in 2020; P &amp;lt; .001). There were no statistical differences in the 7-day and 30-day rates of postoperative emergency visits, hospital readmissions, and reoperations or 30-day mortality in the SHR vs non-SHR groups in the postimplementation era.Conclusions and RelevanceIn this study, implementation of a regional SHR program among patients undergoing elective benign foregut surgery was feasible, safe, and effective. The changes in perioperative care require comprehensive patient education and full multidisciplinary support. An SHR program for benign foregut procedures has the potential to improve patient care and cost-effectiveness in care delivery.
Electric Field Guided Fast and Oriented Assembly of MXene into Scalable Pristine Hydrogels for Customized Energy Storage and Water Evaporation Applications
Authors: Dutta Pronoy , Deb Sujit Kumar , Patra Amalika , Majumdar Abhisek , Karim Golam Masud , Parashar Chintak Kamalesh , Mohanta Manoj Kumar , Qureshi Mohammad , Maiti Uday Narayan 
Published: September 2022

AbstractThe assembly of MXene nanosheets into a hydrogel framework is key to their grand success in practical applications. However, the scalable realization of such stable structures is challenging and requires critically high dispersion concentration for gelation. Herein, a simple yet highly controllable approach for the development of 2D and 3D monolithic hydrogels of MXene via electro‐tunable ordered assembly is reported. Directional electrophoretic drag of MXene and their gelation by voltage‐controlled in situ released ions at the electrode interface gives rise to stable hydrogels with tunable sheet orientations. Nanosheets can be arranged in‐plane or out‐of‐plane depending on the parallel or radial field created by customized electrode assembly. Further, the gelation rate can be easily regulated by the applied potential to achieve self‐standing hydrogel films in a few tens of seconds. The 2D hydrogels display excellent supercapacitive performance of 395 F g−1 at 2 mV s−1 with high retention of 42% at 5000 mV s−1. In another customized application, the 3D‐monolithic MXene hydrogel displays outstanding performance as a solar‐thermal evaporator on behalf of its vertical sheet orientations, showing an excellent evaporation rate of 1.91 kg m−2 g−1. This simple, fast, scalable, and sheet orientation‐controlled assembly can pave the way for future development of MXene hydrogels and beyond.
Biodegradable and Antioxidant DNA Hydrogel as a Cytokine Delivery System for Diabetic Wound Healing
Authors: Wang Zhenghao , Li Wei , Gou Liping , Zhou Ye , Peng Ge , Zhang Jiayi , Liu Jiaye , Li Ruoqing , Ni Hengfan , Zhang Wanli , Cao Ting , Cao Qi , Su Hong , Han Yuan‐Ping , Tong Nanwei , Fu Xianghui , Ilegems Erwin , Lu Yanrong , Berggren Per‐Olof , Zheng Xiaofeng , Wang Chengshi 
Published: September 2022

AbstractImpaired diabetic wound healing is associated with the persistence of chronic inflammation and excessive oxidative stress, which has become one of the most serious clinical challenges. Wound dressings with anti‐inflammatory and reactive oxygen species (ROS)‐scavenging properties are desirable for diabetic wound treatment. In this study, a shape‐adaptable, biodegradable, biocompatible, antioxidant, and immunomodulatory interleukin‐33 (IL‐33)‐cytogel is developed by encapsulating IL‐33 into physically cross‐linked DNA hydrogels and used as wound dressings to promote diabetic wound healing. The porous microstructures and biodegradable properties of the IL‐33‐cytogel ensure the local sustained‐release of IL‐33 in the wound area, where the sustained‐release of IL‐33 is maintained for at least 7 days. IL‐33‐cytogel can induce local accumulation of group 2 innate lymphoid cells (ILC2s) and regulatory T cells (Tregs), as well as M1‐to‐M2 transition at the wound sites. Additionally, the antioxidant and biocompatible characteristics of DNA hydrogels promote the scavenging of intracellular ROS without affecting cell viability. As a result, local inflammation in the diabetic wound area is resolved upon IL‐33‐cytogel treatment, which is accompanied by improved granulation tissue regeneration and accelerated wound closure. This study demonstrates a promising strategy in tissue engineering and regenerative medicine by incorporating DNA hydrogels and cytokine immunotherapy for promoting diabetic wound healing.
Injectable Prevascularized Mature Adipose Tissues (iPAT) to Achieve Long‐Term Survival in Soft Tissue Regeneration
Authors: Louis Fiona , Sowa Yoshihiro , Irie Shinji , Higuchi Yuriko , Kitano Shiro , Mazda Osam , Matsusaki Michiya 
Published: September 2022

AbstractSoft tissue regeneration remains a challenge in reconstructive surgery. So far, both autologous fat implantations and artificial implants methods used in clinical applications lead to various disadvantages and limited lifespan. To overcome these limitations and improve the graft volume maintenance, reproducing a mature adipose tissue already including vasculature structure before implantation can be the solution. Therefore, injectable prevascularized adipose tissues (iPAT) are made from physiological collagen microfibers mixed with human mature adipocytes, adipose‐derived stem cells, and human umbilical vein endothelial cells, embedded in fibrin gel. Following murine subcutaneous implantation, the iPAT show a higher cell survival (84% ± 6% viability) and volume maintenance after 3 months (up to twice heavier) when compared to non‐prevascularized balls and liposuctioned fat implanted controls. This higher survival can be explained by the greater amount of blood vessels found (up to 1.6‐fold increase), with balanced host anastomosis (51% ± 1% of human/mouse lumens), also involving infiltration by the lymphatic and neural vasculature networks. Furthermore, with the cryopreservation possibility enabling their later reinjection, the iPAT technology has the merit to allow noninvasive soft tissue regeneration for long‐term outcomes.
Augmented DNA Nanoarchitectures: A Structural Library of 3D Self‐Assembling Tensegrity Triangle Variants
Authors: Woloszyn Karol , Vecchioni Simon , Ohayon Yoel P. , Lu Brandon , Ma Yinglun , Huang Qiuyan , Zhu Eric , Chernovolenko Daniel , Markus Tiffany , Jonoska Nataša , Mao Chengde , Seeman Nadrian C. , Sha Ruojie 
Published: September 2022

AbstractThe DNA tensegrity triangle is known to reliably self‐assemble into a 3D rhombohedral crystalline lattice via sticky‐end cohesion. Here, the library of accessible motifs is expanded through covalent extensions of intertriangle regions and sticky‐end‐coordinated linkages of adjacent triangles with double helical segments using both geometrically symmetric and asymmetric configurations. The molecular structures of 18 self‐assembled architectures at resolutions of 3.32–9.32 Å are reported; the observed cell dimensions, cavity sizes, and cross‐sectional areas agree with theoretical expectations. These data demonstrate that fine control over triclinic and rhombohedral crystal parameters and the customizability of more complex 3D DNA lattices are attainable via rational design. It is anticipated that augmented DNA architectures may be fine‐tuned for the self‐assembly of designer nanocages, guest–host complexes, and proscriptive 3D nanomaterials, as originally envisioned. Finally, designer asymmetric crystalline building blocks can be seen as a first step toward controlling and encoding information in three dimensions.
Boosting Oxygen‐Evolving Activity via Atom‐Stepped Interfaces Architected with Kinetic Frustration
Authors: Li Rui , Wu Ruoyu , Li Zhibin , Wang Jing , Liu Xiongjun , Wen Yuren , Chiang Fu‐Kuo , Chen Shi‐Wei , Chan K. C. , Lu Zhaoping 
Published: September 2022

AbstractA highly active interface is extremely critical for the catalytic efficiency of an electrocatalyst; however, facilely tailoring its atomic packing characteristics remains challenging. Herein, a simple yet effective strategy is reported to obtain copious high‐energy atomic steps at the interface via controlling the solidification behavior of glass‐forming metallic liquids. By adjusting the chemical composition and cooling rate, highly faceted FeNi3 nanocrystals are in situ formed in an FeNiB metallic glass (MG) matrix, leading to the creation of order/disorder interfaces. Benefiting from the catalytically active and stable atomic steps at the jagged interfaces, the resultant free‐standing FeNi3 nanocrystal/MG composite exhibits a low oxygen‐evolving overpotential of 214 mV at 10 mA cm−2, a small Tafel slope of 32.4 mV dec−1, and good stability in alkaline media, outperforming most state‐of‐the‐art catalysts. This approach is based on the manipulation of nucleation and crystal growth of the solid‐solution nanophases (e.g., FeNi3) in glass‐forming liquids, so that the highly stepped interface architecture can be obtained due to the kinetic frustration effect in MGs upon undercooling. It is envisaged that the atomic‐level stepped interface engineering via the physical metallurgy method can be easily extended to other MG systems, providing a new and generic paradigm for designing efficient yet cost‐effective electrocatalysts.
Super‐Amphiphilic Na2Ti3O7 Nanofibrous Film Enabling Water–Oil Miscibility
Authors: Hu Conghu , Hua Licheng , Huang Bin , Zhou Lüwen , Li Jinbang , Du Jianke 
Published: September 2022

AbstractDue to their extraordinary affinity for both water and oil, super‐amphiphilic materials have garnered considerable interest. A Na2Ti3O7 (NTO) film with super‐amphiphilic properties that enable water and oil miscibility is offered. Multiple nanofibrous 3D porous nanostructures compose the super‐amphiphilic NTO layer. Up to 32–36 times its weight, the film has a high absorption capacity for water and poly‐alpha‐olefin (PAO). The average miscibility ratio of water to oil in the film is ≈6:5. The discovery of NTO nanofibrous film's super‐amphiphilic behavior has significant implications for the development of superwetting materials and their potential applications in the oil emulsion purification and catalyst anchoring industries.
Machine‐Learning Modeling for Ultra‐Stable High‐Efficiency Perovskite Solar Cells
Authors: Hu Yingjie , Hu Xiaobing , Zhang Lu , Zheng Tao , You Jiaxue , Jia Binxia , Ma Yabin , Du Xinyi , Zhang Lei , Wang Jincheng , Che Bo , Chen Tao , Liu Shengzhong (Frank) 
Published: September 2022

AbstractUnderstanding the key factor driving the efficiency and stability of semiconductor devices is vital. To date, the key factor influencing the long‐term stability of perovskite solar cells (PSCs) remains unknown because of the many influencing factors. In this work, through machine learning, the influences of five factors, including grain size, defect density, bandgap, fluorescence lifetime, and surface roughness, on the efficiency and stability of PSCs have been revealed. It is found that the bandgap has the greatest influence on the efficiency, and the surface roughness and grain size are most influential to the long‐term stability. A mathematical model is given to predict efficiency based on fluorescence lifetime and bandgap. Guided by the model, four groups of experiments are conducted to confirm the machine‐learning predictions and a PSC with 23.4% efficiency and excellent long‐term stability is obtained, as manifested by retention of 97.6% of the initial efficiency after 3288 h aging in the ambient environment, the best stability under these conditions. This work shows that machine learning is an effective means to enrich semiconductor physical models.
Stabilization of Lattice Oxygen in Li‐Rich Mn‐Based Oxides via Swing‐like Non‐Isothermal Sintering
Authors: Zhang Yu‐Han , Zhang Ding , Wu Lin‐Rong , Ma Jun , Yi Qun , Wang Zhaoxiang , Wang Xuefeng , Wu Zhen , Zhang Chu , Hu Naifang , Haw Shu‐Chih , Chen Jin‐Ming , Hu Zhiwei , Cui Guanglei 
Published: September 2022

AbstractRedox from the holes at the O2p orbitals is a well‐known phenomenon in Li‐rich Mn‐based batteries. However, such an anionic redox process results in the formation of O2, leading to structural instability owing to unstable O2p holes. Herein, a swing‐like non‐isothermal sintering technique is used to stabilize the lattice oxygen by suppressing the formation of O2 during charging. It reduces both the number of intrinsic oxygen vacancies of the Li‐rich Mn‐based oxides and the formation of O2 during charging as compared with traditional constant high‐temperature sintering. Consequently, the number of holes generated during charging in the O2p orbitals increases, whereas the number of unstable O2p holes forming O2 decreases. Therefore, the sample prepared via swing‐like non‐isothermal sintering exhibited considerably slower voltage fading and better cycling stability. This study provides valuable guidelines for stabilizing the lattice oxygen and improving the structural stability of the oxide cathodes for electrochemical energy storage.
Assembly‐Free Fabrication of High‐Performance Flexible Inorganic Thin‐Film Thermoelectric Device Prepared by a Thermal Diffusion
Authors: Ao Dong‐Wei , Liu Wei‐Di , Zheng Zhuang‐Hao , Shi Xiao‐Lei , Wei Meng , Zhong Yi‐Ming , Li Meng , Liang Guang‐Xing , Fan Ping , Chen Zhi‐Gang 
Published: September 2022

AbstractHigh relative contact electrical resistance and poor flexibility in inorganic thin‐film thermoelectric devices significantly limit their practical applications. To overcome this challenge, a one‐step thermal diffusion method to fabricate assembly‐free inorganic thin‐film thermoelectric devices is developed, where the in situ grown electrode delivers an excellent leg‐electrode contact, leading to high output power and flexibility in the prepared p‐type Sb2Te3/n‐type Bi2Te3 thin‐film device, which is composed of 8 pairs of p‐n junctions. Such a device shows a very low relative contact electrical resistance of 7.5% and a high power density of 1.42 mW cm–2 under a temperature difference of 60 K. Less than 10% change of the whole electrical resistance before and after bending test indicates the robust bending resistance and stability of the device. This study indicates that the novel assembly‐free one‐step thermal diffusion method can effectively enhance the leg‐electrode contact, the device thermoelectric performance, bending resistance, and stability, which can inspire the development of thin‐film thermoelectric devices.
Debilitating hip degeneration in trichothiodystrophy: Association with ERCC2/XPD mutations, osteosclerosis, osteopenia, coxa valga, contractures, and osteonecrosis
Authors: DiGiovanna John J. , Randall Grant , Edelman Alexandra , Allawh Rina , Xiong Michael , Tamura Deborah , Khan Sikandar G. , Rizza Elizabeth R. H. , Reynolds James C. , Paul Scott M. , Hill Suvimol C. , Kraemer Kenneth H. 
Published: September 2022

AbstractTrichothiodystrophy (TTD) is a rare, autosomal recessive, multisystem disorder of DNA repair and transcription with developmental delay and abnormalities in brain, eye, skin, nervous, and musculoskeletal systems. We followed a cohort of 37 patients with TTD at the National Institutes of Health (NIH) from 2001 to 2019 with a median age at last observation of 12 years (range 2–36). Some children with TTD developed rapidly debilitating hip degeneration (DHD): a distinctive pattern of hip pain, inability to walk, and avascular necrosis on imaging. Ten (27%) of the 37 patients had DHD at median age 8 years (range 5–12), followed by onset of imaging findings at median age 9 years (range 5–13). All 10 had mutations in the ERCC2/XPD gene. In 7 of the 10 affected patients, DHD rapidly became bilateral. DHD was associated with coxa valga, central osteosclerosis with peripheral osteopenia of the skeleton, and contractures/tightness of the lower limbs. Except for one patient, surgical interventions were generally not effective at preventing DHD. Four patients with DHD died at a median age of 11 years (range 9–15). TTD patients with ERCC2/XPD gene mutations have a high risk of musculoskeletal abnormalities and DHD leading to poor outcomes. Monitoring by history, physical examination, imaging, and by physical medicine and rehabilitation specialists may be warranted.
Photochemical C(sp2)−H Pyridination via Arene–Pyridinium Electron Donor–Acceptor Complexes
Authors: Lasky Matthew R. , Salvador Tolani K. , Mukhopadhyay Sukrit , Remy Matthew S. , Vaid Thomas P. , Sanford Melanie S. 
Published: September 2022

AbstractThis report describes the development of a photochemical method for C(sp2)−H pyridination that leverages the photoexcitation of electron donor–acceptor (EDA) complexes. Experimental and DFT studies show that black light (λmax≈350 nm) irradiation of solutions of protonated pyridines (acceptors) and aromatic C−H substrates (donors) results in single electron transfer to form aryl radical cation intermediates that can be trapped with pyridine nucleophiles under aerobic conditions. With some modification of the reaction conditions, this EDA activation mode is also effective for promoting the oxidatively triggered SNAr pyridination of aryl halides. Overall, this report represents an inexpensive and atom‐economical approach to photochemical pyridination reactions that eliminates the requirement of an exogenous photocatalyst.
Chemical Synthesis, Characterization, and Properties of Multi‐Element Nanoparticles
Authors: Kusada Kohei , Mukoyoshi Megumi , Wu Dongshuang , Kitagawa Hiroshi 
Published: September 2022

AbstractMulti‐element nanoparticles (NPs) consisting of five or more elements have been increasingly studied in the past five years. Their emergence is taking materials science one step further because they exhibit superior properties to those of conventional NPs in a range of respects, including catalysis. This Review focuses on the recent progress in multi‐element NPs regarding synthesis, especially with regard to chemical synthesis, characterization, and properties. We begin with a brief introduction of multi‐element NPs and an overview of their synthesis methods. Then, we present representative examples of multi‐element alloy NPs and ceramic NPs, including oxide NPs prepared by chemical syntheses. This Review intends to provide useful insights into the chemical methods that are used to synthesize multi‐element NPs, and includes a discussion on the possibilities arising from their use in new functional materials.
Stereomodulation of Poly(4‐methyl‐1‐pentene): Adoption of a Neglected and Misunderstood Commercial Polyolefin
Authors: Wentz Charlotte M. , Fischbach Danyon M. , Sita Lawrence R. 
Published: September 2022

AbstractA toolbox of living coordination polymerization methods based on CPAM group 4 metal initiators has been applied for the stereomodulation of poly(4‐methyl‐1‐pentene) (PMP) tacticity to provide new fundamental forms in which thermal phase transitions, Tg and Tm, can be adjusted over a wide range. Also reported for the first time are the synthesis and properties of authenticated 1,2‐regioregular atactic PMP, which serves to correct past errors regarding this fundamental polyolefin.