bluuebunny/crossref_metadata_2025_split huggingface dataset:
Іnfluence of engaging in single combats on physical development of students, them power capabilities, endurance and speed in the conditions of sport club of university"
Authors: Shapar K. , Kolomeitseva О. , Dovhopol E. , Gordinskiy Y. 
Published: April 2022

In the article the questions of theory and practice of influence of engaging in single combats (By martial arts) are examined on development of power possibilities and power endurance for students, them common physical development in the process of employment in the sport club of establishment of higher education.
For a given hour before laying the foundations of the great enlightenment, it is important to stand the task - the creation of minds for the preservation of the health of students under the hour of the initial process. An aim stood before the group of teachers - to investigate influence of methodology of teaching of discipline of single combat, in the conditions of sport club of university, on physical development of students, development of them power capabilities, speeds of reaction and common strengthening of health (on methodology of G. Apanasenka, methods of determination of motive activity, methods of mathematical statistics [1, 2].
As a result of experiment, drawn conclusion about influence of employments by single combats in the conditions of sport club of university on physical development of students, them power capabilities, endurance, and speed.
In experimental groups from single combats a greater positive dynamics is fixed, than in a control group. The analysis of influence of engaging in single combats on the indexes of bodily condition of students allows establishing, that the expressed optimization of work of the cardiovascular and respiratory systems was marked. Positive influence of the sectional engaging in single combats is educed on the indexes of bodily condition, especially on speed qualities, and endurance. The conducted experiment and research in a sport club of university confirmed expediency of the use of sectional employments after single combats with students.
ENGLISH PARAPHRASING TROUGH INITIAL STAGE TECHNIQUE TO DEVELOP WRITING SKILL
Authors: Arfiani Nina , Mauke Nursida , Mukmin Mukmin 
Published: April 2022

Abstract
The purpose of this research is to know whether the initial stage can improve writing skill, to find out how their paraphrase capabilities result using the initial stage, and to know the students’ writing skill. This research employed quasi experimental design. Independent variable of this research was the initial stage technique and the dependent variable was the students’ writing skill. The population of this research was the eleventh grade students of MAN 1 Luwuk Banggai in 2020/2021 academic year. The way of taking the sample was by using purposive sampling. The samples were class XI IPA 1 as the experimental group and class XI IPA 2 as the control group. The test consisted of pre-test and post-test. Data were analyzed statistically. After analyzed the data, the result revealed that the t-counted was 14.38 with a degree of freedom 70 and a significance level of 0.05, t-table was 1.666. Therefore, the t-test result was higher than the t-table. It means that the hypothesis was accepted. In conclusion, the result showed that the initial stage technique of paraphrasing can develop writing skill of the eleventh grade students’ of MAN 1 Luwuk Banggai.
Keywords: Develop; Writing skill; Initial Stage Technique.
En Pos del Edén Occidentalizado. Turismo y Naturaleza en la Prensa del Porfiriato, México
Authors: Reyes Marco Aurelio Almazán 
Published: April 2022

El presente artículo ilustra que las ideas vertidas en la prensa del Porfiriato (1876-1911) sobre la incorporación de los recursos naturales en el incipiente turismo en México pretendían la adecuación de paisajes acorde a parámetros modernos y de índole liberal, los cuales se consideraban, por parte de las élites nacionales, apropiados para atraer y recibir turistas extranjeros, principalmente estadounidenses y europeos occidentales. A partir de la revisión del contenido de rotativos de ese período, y su contextualización, se interpreta que coadyuvaron a la difusión de las actividades del turismo en el país pero también a su legitimación e instauración como “territorio
El presente artículo ilustra que las ideas vertidas en la prensa del Porfiriato (1876-1911) sobre la incorporación de los recursos naturales en el incipiente turismo en México pretendían la adecuación de paisajes acorde a parámetros modernos y de índole liberal, los cuales se consideraban, por parte de las élites nacionales, apropiados para atraer y recibir turistas extranjeros, principalmente estadounidenses y europeos occidentales. A partir de la revisión del contenido de rotativos de ese período, y su contextualización, se interpreta que coadyuvaron a la difusión de las actividades del turismo en el país pero también a su legitimación e instauración como “territorio del turismo” y de atractivos turísticos. En tal proceso, sus propuestas de adecuación de la naturaleza consideraban más los beneficios para algunos actores sociales, como empresarios, turistas de alto poder adquisitivo o extranjeros, en detrimento de otros, como la población campesina e indígena, o llegaban a implicar impactos para otros elementos del paisaje, como la fauna.
معايير النص عند روبرت دي بوجراند وأثرها في فهم الخطاب النبوي: حديث دواء المبطون نموذجا
Authors: Abd Gani Muhammad Izuan , Ali Asem Shahedeh 
Published: April 2022

This study analysed the text structure with textual standards proposed by Robert de beaugrande where they are among the essential tools of language that play a role in dissecting the construction of the text, achieving its textual coherence, conceptual interdependence, and communication. The study aims to uncover its elements: cohesion, coherence, intentionality, acceptability, situationally, informativity, and intertextuality and their impact on the understanding of prophetic discourse. The approach for this study is qualitative and based on the content analysis approach. This approach addresses the description, analysis, and explanation of the hadith in the light of text linguistics. The results indicate that this hadith has the seven elements of the textual standards, starting with the cohesion whose elements are available; reference, substitution, ellipsis, conjunction, and recurrence, and the criterion of coherence and its elements are the situation, context, metaphor and correlation, and the manifestations of intentionality and acceptability in the hadith are revealed, as well as the criteria of situationally, informativity and intertextuality in it, which all emphasise the coherence, conceptual interdependence, and communication of the hadith and their impact on the interpretation and understanding of the hadith in the recipient.
تناولت هذه الدراسة التحليل لبنية نص بمعطيات اللسانيات الحديثة من خلال رصد عناصر معايير النص عند روبرت دي بوجراند في نص حديث الطب النبوي العلاجي لدواء المبطون. تعد معايير النص التي اقترحها دي بوجراند من أهم الوسائل اللغوية التي تقوم بدورها في تشريح بناء النص، وتحقيق تماسكه النصي وترابطه المفهومي والتواصلي. تهدف الدراسة إلى الكشف عن عناصر النص، وهي: الاتساق، والانسجام، والقصدية، والمقبولية، والموقفية، والإعلامية والتناص، وبيان أثرها في فهم الخطاب النبوي. والمنهج المتبع لهذه الدراسة هو المدخل الكيفي والاعتماد على منهج تحليل المحتوى؛ إذ يتطرّق هذا المنهج إلى وصف وتحليل وشرح نص الحديث في ضوء علم اللغة النصي، بإبراز عناصر معايير النص والوقوف على أهميتها في تماسك وترابط نص الحديث وأثرها في فهمه. وتشير النتائج إلى أن الحديث الذي يتحدث عن دواء المبطون تتوافر فيه عناصر معايير النص السبعة؛ ما يؤكد على تماسك وترابط الحديث، كما أنها تؤكد على أثرها في تفسير وفهم الحديث عند المتلقي.
Novel Analysis of Coronary Angiography in Predicting the Formation of Ventricular Aneurysm in Patients With Acute Myocardial Infarction After Percutaneous Coronary Intervention
Authors: Yu Pujiao , Xi Peng , Tang Yu , Xu Jiahong , Liu Yang 
Published: April 2022

BackgroundVentricular aneurysm (VA) is a serious complication of acute myocardial infarction (AMI), with a very poor prognosis. Early-stage prophylactic treatment is effective in preventing the formation of VAs. However, the existing predictive models for VA formation lack the sensitivity and specificity necessary for evaluating patients with MI. This study aimed to explore the potential use of coronary angiography and establish a more precise prediction model for VA in patients with MI.MethodsPatients with VA (n = 52) admitted to our medical center between June 2020 and July 2021 with previous emergency percutaneous coronary intervention for AMI were retrospectively included in this database study. Controls that matched 4:1 with the VA cases during the same period were enrolled. The baseline characteristics and coronary angiograms of the enrolled individuals were obtained from the electronic medical record system. The curve length of the distance from the main criminal lesion to its ostia (DLO) and distal (DLD) in the coronary artery were measured with ImageJ. Binary logistic regression analysis was used to identify the predictive factors. The model performance was evaluated by receiver operating characteristic curve analysis.ResultsBinary analysis revealed maximum serum cardiac troponin I level (odds ratio [OR] = 1.046, 95% confidence interval [CI] = 1.027–1.066, P &lt; 0.001), serum brain natriuretic peptide level (OR = 1.001, 95% CI = 1.000–1.002, P = 0.007), left anterior descending artery as the culprit lesion (OR = 5.091, 95% CI = 2.080–12.457, P &lt; 0.001), and that single-vessel disease (OR = 1.809, 95% CI = 0.967–3.385, P &lt; 0.001), stenosis in the main lesion (OR = 1.247, 95% CI = 1.173–1.327, P &lt; 0.001), DLO (OR = 1.034, 95% CI = 1.019–1.049, P &lt; 0.001), DLD (OR = 1.061, 95% CI = 1.043–1.079, P &lt; 0.001), and DLD/DLD (OR = 0.033, 95% CI = 0.010–0.117, P &lt; 0.001) were the independent variables for predicting VA formation in MI patients.ConclusionOur study first used quantified information of coronary lesions to establish a predictive model and proved that a longer DLD had the greatest potential in predicting the incidence of VA. Its related parameters including DLO and DLO/DLD ratio were also correlated with the incidence of VA. These findings may provide a new reference for the early identification of high-risk MI patients and preventing VA.
Regulatory Considerations Specific to Liposome Drug Development as Complex Drug Products
Authors: Wang Yuwei , Grainger David W. 
Published: April 2022

Nearly a half-century after original liposome discovery as a prospective lipid pharmaceutical carrier, the global liposomal drug delivery market has increased dramatically, with an annual market growth rate of 13.2%, valued at ∼$6,993 million by 2027. As an intrinsically complex delivery system, liposomal formulations face much greater characterization and regulatory review challenges than traditional small molecule drugs and biologics. Due to rapid liposomal drug development, both European Medicines Agency (EMA) and US Food and Drug Administration (FDA) now provide regulatory guidance for new liposomal drug application reviews. The expanding global liposome drug market and associated driving forces for increased research and development (R&amp;D) in novel liposomal products are key factors propelling liposomal drug interests. We review and compare EU and US regulations on liposomal drug submissions, and provide insights into regulatory strategies throughout the entire liposomal drug development process. This addresses current gaps noted between liposome-based drug development in research labs and current regulatory guidance for liposomal drug approvals in order to facilitate more efficient, less costly, and less risky complex drug development.
Pinpointing the Geographic Origin of 165-Year-Old Human Skeletal Remains Found in Punjab, India: Evidence From Mitochondrial DNA and Stable Isotope Analysis
Authors: Sehrawat J.S. , Agrawal Shailesh , Sankhyan Deeksha , Singh Monika , Kumar Sachin , Prakash Satya , Rajpal Richa , Chaubey Gyaneshwer , Thangaraj Kumarasamy , Rai Niraj 
Published: April 2022

In 2014, 157 years after the Sepoy Mutiny of 1857, several unidentified human skeletons were discovered in an abandoned well at Ajnala, Punjab. The most prevailing hypothesis suggested them as Indian soldiers who mutinied during the Indian uprising of 1857. However, there is an intense debate on their geographic affinity. Therefore, to pinpoint their area of origin, we have successfully isolated DNA from cementum-rich material of 50 good-quality random teeth samples and analyzed mtDNA haplogroups. In addition to that, we analyzed 85 individuals for oxygen isotopes (δ18O values). The mtDNA haplogroup distribution and clustering pattern rejected the local ancestry and indicated their genetic link with the populations living east of Punjab. In addition, the oxygen isotope analysis (δ18O values) from archaeological skeletal remains corroborated the molecular data and suggested the closest possible geographical affinity of these skeletal remains toward the eastern part of India, largely covering the Gangetic plain region. The data generated from this study are expected to expand our understanding of the ancestry and population affinity of martyr soldiers.
Identification of a Novel Immune Landscape Signature for Predicting Prognosis and Response of Colon Cancer to Immunotherapy
Authors: Wang Zheng , Song Jingru , Azami Nisma Lena Bahaji , Sun Mingyu 
Published: April 2022

PurposeTo construct an immune-related gene prognostic index (IRGPI) for colon cancer and elucidate the molecular and immune characteristics as well as the benefit of immune checkpoint inhibitor (ICI) therapy in IRGPI-defined groups of colon cancer.Experimental DesignTranscriptional and clinical data of colon cancer samples were obtained from The Cancer Genome Atlas (TCGA) (n = 521). Immune-related genes were obtained from ImmPort and InnateDB databases. 21 immune-related hub genes were identified byweighted gene co-expression network analysis (WGCNA). the Cox regression method was used to construct IRGPI and validated with Gene Expression Omnibus (GEO) dataset (n = 584). Finally, the molecular and immune profiles in the groups defined by IRGPI and the benefit of ICI treatment were analyzed.Results8 genes were identified to construct IRGPI. IRGPI-low group had a better overall survival (OS) than IRGPI-high group. And this was well validated in the GEO cohort. Overall results showed that those with low IRGPI scores were enriched in antitumor metabolism, and collated with high infiltration of resting memory CD4 T cells and less aggressive phenotypes, benefiting more from ICI treatment. Conversely, high IRGPI scores were associated with cell adhesion molecules (CAMs) and chemokine signaling pathways, high infiltration of macrophage M1, suppressed immunity, more aggressive colon cancer phenotypes, as well as reduced therapeutic benefit from ICI treatment.ConclusionsIRGPI is a promising biomarker to differentiate the prognostic and molecular profile of colon cancer, as well as the therapeutic benefits of ICI treatment.
The Prognostic and Clinicopathological Significance of Systemic Immune-Inflammation Index in Bladder Cancer
Authors: Li Jinze , Cao Dehong , Huang Yin , Xiong Qiao , Tan Daqing , Liu Liangren , Lin Tianhai , Wei Qiang 
Published: April 2022

BackgroundSystemic immune-inflammation index (SII) has recently emerged as a biomarker for the prognosis of a variety of malignant tumors. However, the role of SII in bladder cancer (BC) remains unclear. To this end, we performed a pooled analysis to investigate the prognostic value of preoperative SII in patients with BC.MethodsA comprehensive search of electronic databases (PubMed/Medline, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials) was conducted to determine the eligible studies that were published until January 2022. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association between preoperative SII and the prognosis and clinicopathological characteristics of BC.ResultsTen studies with 7,087 patients were included in this analysis. SII was observed to be correlated with inferior overall survival (HR = 1.22, 95% CI 1.04–1.44, p = 0.013), cancer-specific survival (HR = 1.68, 95% CI 1.14–2.47, p = 0.009), and recurrence-free survival (HR = 1.29, 95% CI 1.03–1.61, p = 0.027). An increased preoperative SII was also associated with poor tumor differentiation, higher tumor stage, presence of lymph node involvement, and tumor size ≥3 cm (all p &lt; 0.05).ConclusionsAn elevated preoperative SII is significantly associated with worse survival outcomes and adverse pathological features in patients with BC. Hence, SII may serve as a strong independent prognostic predictor for patients with BC after surgery.
TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage–Related Neutrophilic Inflammation in Asthma
Authors: Shi Bingqing , Hao Yuqiu , Li Wei , Dong Hongna , Xu Mengting , Gao Peng 
Published: April 2022

PurposeAlthough recent studies have highlighted the link of TIPE2 and asthma airway inflammation, its roles and molecular mechanisms in different asthma inflammatory phenotypes remain largely unknown. We evaluated sputum TIPE2 expression level and its correlation with different asthma phenotypes. Additionally, we explored the roles and mechanism of TIPE2 in M1 polarization of macrophages.MethodsA total of 102 asthma patients who underwent sputum induction were enrolled to evaluate the expression level of TIPE2 and its association with different asthma phenotypes. To explore the roles and mechanism of TIPE2 in M1 polarization of macrophages, THP-1 monocytes stimulated with phorbol-12-myristate-13-acetate, were used as a model of undifferentiated (M0) macrophages, and M0 macrophages were treated with lipopolysaccharide to induce M1 macrophages.ResultsThe sputum TIPE2 level was significantly lower in patients with neutrophilic asthma (NA) and higher in patients with eosinophilic asthma (EA) compared with patients with paucigranulocytic asthma. The levels of IL-1β, TNF-α and IL-6 were highest in NA compared with other groups. TIPE2 levels in sputum negatively correlated with IL-1β and TNF-α levels but positively correlated with IL-4, IL-5, IL-13, and IL-10 levels (P &lt; 0.05). In vitro, TIPE2 enhanced Nrf2/HO-1 pathway activation in macrophages and inhibited LPS-induced M1 macrophage differentiation and related cytokine release. Further analysis showed that the Nrf2 inhibitor ML385 weakened TIPE2-induced activation of the Nrf2/HO-1 pathway, as well as TIPE2-induced suppression in M1 polarization of macrophage and inflammatory cytokines secretion.ConclusionsTIPE2 expression level was highly down-regulated in NA and was negatively correlated with inflammatory factors (IL-1β and TNF-α). Aberrant expression of TIPE2 may target the Nrf2/HO-1 pathway to inhibit M1 macrophage–related neutrophilic inflammation in asthma.
Local Mucosal CO2 but Not O2 Insufflation Improves Gastric and Oral Microcirculatory Oxygenation in a Canine Model of Mild Hemorrhagic Shock
Authors: Hof Stefan , Truse Richard , Weber Lea , Herminghaus Anna , Schulz Jan , Weber Andreas P. M. , Maleckova Eva , Bauer Inge , Picker Olaf , Vollmer Christian 
Published: April 2022

IntroductionAcute hemorrhage results in perfusion deficit and regional hypoxia. Since failure of intestinal integrity seem to be the linking element between hemorrhage, delayed multi organ failure, and mortality, it is crucial to maintain intestinal microcirculation in acute hemorrhage. During critical bleeding physicians increase FiO2to raise total blood oxygen content. Likewise, a systemic hypercapnia was reported to maintain microvascular oxygenation (μHbO2). Both, O2and CO2, may have adverse effects when applied systemically that might be prevented by local application. Therefore, we investigated the effects of local hyperoxia and hypercapnia on the gastric and oral microcirculation.MethodsSix female foxhounds were anaesthetized, randomized into eight groups and tested in a cross-over design. The dogs received a local CO2-, O2-, or N2-administration to their oral and gastric mucosa. Hemorrhagic shock was induced through a withdrawal of 20% of estimated blood volume followed by retransfusion 60 min later. In control groups no shock was induced. Reflectance spectrophotometry and laser Doppler were performed at the gastric and oral surface. Oral microcirculation was visualized by incident dark field imaging. Systemic hemodynamic parameters were recorded continuously. Statistics were performed using a two-way-ANOVA for repeated measurements andpost hocanalysis was conducted by Bonferroni testing (p&lt; 0.05).ResultsThe gastric μHbO2decreased from 76 ± 3% to 38 ± 4% during hemorrhage in normocapnic animals. Local hypercapnia ameliorated the decrease of μHbO2from 78 ± 4% to 51 ± 8%. Similarly, the oral μHbO2decreased from 81 ± 1% to 36 ± 4% under hemorrhagic conditions and was diminished by local hypercapnia (54 ± 4%). The oral microvascular flow quality but not the total microvascular blood flow was significantly improved by local hypercapnia. Local O2-application failed to change microvascular oxygenation, perfusion or flow quality. Neither CO2nor O2changed microcirculatory parameters and macrocirculatory hemodynamics under physiological conditions.DiscussionLocal hypercapnia improved microvascular oxygenation and was associated with a continuous blood flow in hypercapnic individuals undergoing hemorrhagic shock. Local O2application did not change microvascular oxygenation, perfusion and blood flow profiles in hemorrhage. Local gas application and change of microcirculation has no side effects on macrocirculatory parameters.