bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical relevance of deep learning models in predicting the onset timing of breakthrough cancer pain
Authors: Bang Yeong Hak , Choi Yoon Ho , Park Mincheol , Shin Soo-Yong , Kim Seok Jin 
Published: October 2022

Abstract
Introduction

Breakthrough cancer pain (BTcP) is a challenging clinical problem that is encountered in the management of cancer pain. We aimed to investigate the clinical relevance of deep learning models that predict the of BTcP onset in hospitalized patients.

Methods

We defined BTcP as the pain with a numerical rating scale (NRS) score of ≥ 4. We investigated the performance of the deep learning models using the Matthews correlation coefficient (MCC) with different input lengths and time binning. All the pain records were obtained from the electronic medical records of the hematology-oncology wards in a Samsung Medical Center between July 2016 and February 2020. The model was externally validated using the holdout method with 20% of the datasets.

Results

The most common type of cancer was lung cancer (n = 745, 21.7%), and the median BTcP per day was 1.01. The NRS pain records showed circadian patterns that correlated with NRS pain patterns of the previous days. The correlation of the NRS scores showed a positive association with the closeness of the NRS pattern of the day with forecast date and size of time binning. The long short-term memory-based model exhibited a good performance by demonstrating 9 times the best performance and 8 times the second-best performance among 21 different settings. The best performance was achieved with 120 h input and 12 h bin lengths (MCC: 0.4927).

Conclusion

Our study demonstrated the possibility of predicting BTcP using deep learning models, thereby suggesting that preemptive cancer pain management using deep learning will improve patients’ daily life.
Morphology and Performance of PolyVinyl Chloride Thin Films Doped with Polyorganosilanes against Photodegradation
Authors: Mohamed Safaa , Yousif Emad , Hameed Ayad S. , Ahmed Dina S. , Zainulabdeen Khalid , Saleh Hamid M. , Husain Amani A. , Bufaroosha Muna 
Published: October 2022

Abstract
The importance of polymeric additives has taken an important role in industrial technology and its development and the increase in the consumption period of industrial products, especially plastic products. Therefore, a different type of polymeric additive was used, which can be classified as another type of polymeric additive, where three types of polymers were synthesized as polymeric additives. These polymers differ from each other only in stereo geometry. Three geometric shapes of the polymer were synthesized, namely, ortho, meta, and para polymers. They were studied as photo stabilizers for PVC and compared as the best photostabilizer for PVC. Polyorganosiloxane was invented by various technologies. Polyorganosilanes and poly(vinyl chloride) (PVC) were combined to create homogeneous films. Various methods were used to investigate the effects of long-term irradiation on polyorganosilane-containing films. The development of side products containing polyene and carbonyl groups was observed in the infrared spectra of PVC films before, during, and after irradiation. The absorption bands' intensities of the functional groups associated with the polyorganosilanes were lower when it was present. Furthermore, it was observed that the weight of PVC films dropped less when irradiating them after hybridization with polyorganosilanes. In the presence of polyorganosilanes, there was also a minor alteration in the surface of irradiated PVC. Photodegradation of PVC is inhibited by polyorganosilanes. Hence, the role of polyorganosilanes to stabilize PVC against UV exposure has been studied.
The Multivariate Generalized Linear Hawkes Process in High Dimensions with Applications in Neuroscience
Authors: Fallahi Masomeh , Pourtaheri Reza , Eskandari Farzad 
Published: October 2022

Abstract
The Hawkes process models have been recently become a popular tool for modeling and analysisof neural spike trains. In this article, motivated by neuronal spike trains study, we propose a novelmultivariate generalized linear Hawkes process model, where covariates are included in the intensityfunction. We consider the problem of simultaneous variable selection and estimation for the multivariategeneralized linear Hawkes process in the high-dimensional regime. Estimation of the intensity function ofthe high-dimensional point process is considered within a nonparametric framework, applying B-splinesand the SCAD penalty for matters of sparsity. We apply the Doob-Kolmogorov inequality and themartingale central limit theory to establish the consistency and asymptotic normality of the resultingestimators. Finally, we illustrate the performance of our proposal through simulation and demonstrateits utility by applying it to the neuron spike train data set.
Adult focal β-cell nesidioblastosis: A case report and literature review
Authors: Tu Kui , Zhao Li-Jin , Gu Jin 
Published: October 2022

Abstract
BACKGROUND:
Nesidioblastosis usually refers to a series of clinical manifestations caused by the proliferation of β-cells in pancreatic islets, and these clinical manifestations are hyperinsulinemia and persistent hypoglycemia. According to the size of the lesion, nesidioblastosis is divided into focal nesidioblastosis, diffuse nesidioblastosis and atypical nesidioblastosis, and its pathogenesis is still unclear. Nesidioblastosis is mainly seen in infants and rarely reported in adults, especially focal nesidioblastosis, which is difficult to distinguish from insulinoma.
CASE SUMMARY:
We report a case of adult focal β-cell nesidioblastosis in which the preoperative diagnosis was insulinoma. The patient was a 48-year-old male who suffered from repeated morning and fasting palpitations, sweating, and severe disturbance of consciousness for 5 years. His blood glucose was found to be as low as 1.79 mmol/L during an attack. However, abdominal computed tomography showed no abnormalities. Magnetic resonance imaging and endoscopic ultrasonography demonstrated a nodular mass in the head of the pancreas, combined with hyperinsulinemia and high serum C-peptide. The patient was diagnosed with insulinoma and underwent Beger surgery; however, the postoperative pathological results showed nesidioblastosis.
CONCLUSION:
Although surgical resection is the preferred option for nesidioblastosis, some cases can be treated non-surgically. In order to increase clinicians' understanding of nesidioblastosis, it is necessary to review the pathogenesis, diagnosis and treatment of this disease.
The relationship between personality and musical preferences in college student
Authors: wang xiao , chen tongjun , bao yanmin 
Published: October 2022

Abstract
There is a universal love of music among young people all over the world. In previous studies. In college students, the individual's personality traits and the type of music have been very stable. Individual music preference is influenced by many conditions, Such as age, gender, knowledge structure, and personality traits. This study aims to investigate how people’s personality influence their’s music preferences, A Short Test of Music Preference Questionnaire (STOMP) was succeed in testing foreigners’ musical preferences, excluding certain music genres, showing the same result that the questionnaire has cross-cultural consistency and validity. Overall, the aim of this study is to gain a deeper understanding of the relationship between music preference and personality. We found that the personality characteristics of Openness to Experience and Conscientiousness have an important influence on the choice of music preference. At the same time, there is a significant correlation between the Big Five personality traits and music preference choices.
Clinical efficacy of anastomotic reinforcement suture in preventing anastomotic leakage after rectal cancer surgery: a systematic review and meta-analysis
Authors: Zhang Tao , Wang Gang , Qiu Lei , Lu Feng , Fang Guida , Yin Kaihong , Miao Yongchang 
Published: October 2022

Abstract
Background and objectives: Anastomotic leakage (AL) is a common postoperative complication of rectal cancer, and the reinforced efficacy of the suture is still contentious. This study aimed to investigate the safety and effectiveness of anastomotic reinforcement suture in the prevention of anastomotic leakage after rectal cancer surgery using the Meta method.
Methods: We searched eight major databases (PubMed, Embase, Cochrane Library, Sinomed, Web of Science, Wanfang, VIP, and CNKI) in July 2022 to perform a meta-analysis to evaluate the efficacy of anastomotic reinforcement suture after rectal cancer surgery. The primary outcome measures were anastomotic leakage rate, anastomotic bleeding rate, and infection rate.
Results: A total of 10 articles and 1573 subjects were included in the study, including 754 cases in the reinforced suture group and 819 cases in the unreinforced suture group. The results showed that compared to the unreinforced suture, the incidence of anastomotic leakage was less (OR = 0.27, 95% CI 0.17-0.41, P < 0.001) and the incidence of infection was less (OR = 0.43, 95% CI 0.21-0.88, P < 0.05), shorter hospital stay (MD = -0.57, 95% CI -1.15-0.00, P≤0.05), earlier anal exhaust time (MD = -0.3, 95% CI -0.23--0.03, P < 0.05). The operative time (MD = 18.79, 95% CI: 13.57-24.01, P < 0.001) was higher than that of the unreinforced suture group. There were no significant differences in intraoperative blood loss (MD = 0.45, 95% CI -6.96-7.87, P > 0.05), incidence of anastomotic bleeding (OR = 0.44, 95% CI 0.13-1.44, P > 0.05), and incidence rates of intestinal obstruction (OR = 0.71, 95% CI 0.32-1.57, P > 0.05).
Conclusions: Existing studies indicate that anastomotic reinforcement suture can significantly reduce the incidence of anastomotic leakage, which has the value of clinical promotion. However, this conclusion still needs multicenter high-quality RCTs with a large sample size to further confirm.
Metamorphic and post-settlement success of Holothuria scabra reared on microalgal concentrates compared with live microalgae
Authors: Garpa Tomilyn Jan , Caasi Olivier Josh , Juinio-Meñez Marie Antonette 
Published: October 2022

Abstract
Commercially available microalgae concentrates used in the culture of Holothuria scabra were compared to live microalgae. Larvae were reared under a fixed daily feeding ration of 20,000 cells mL− 1 using three commercial concentrates (Instant Algae®, Reed Mariculture Inc.): TW 1200 (Thalassiosira weisflogii; TW), TISO 1800 (Isochrysis sp.; TISO), and Shellfish 1800 (mixed diatom; SHELL) and compared with live Chaetoceros calcitrans (CC). The efficacy of diets was evaluated based on larval growth, development, and survival to late auricularia (LA) with hyaline spheres (HS) and post settled juveniles. The average size in TISO (855.7 ± 62.67µm) was significantly higher compared with SHELL. In contrast, larvae in TW did not progress beyond middle LA. Development was much better in CC compared to all the microalgal concentrates. Larvae fed CC reached LA stage earlier, attained significantly larger sizes (1028.43 ± 19.38 µm), and have significantly higher incidence and size of HS. Better metamorphic and settlement performance of larvae in CC and SHELL treatment maybe related to the higher carbohydrate content in these feeds. Average post settled juveniles in CC (9,268 ± 2,183.79) were over three times more in SHELL, and an order of magnitude for TISO. Higher costs per juvenile can be largely attributed to the low post settled juvenile yield and longer feeding duration when using microalgae concentrates. The estimated cost of producing each juvenile using SHELL is $0.036 and $0.210 for TISO, compared to $0.009 per juvenile using CC. Opportunities to optimize the use of microalgal concentrates as supplemental feeds are discussed.
Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail
Authors: Rogalski Aymeric , S.W.A. Himaya , Lewis Richard 
Published: October 2022

AbstractMarine cone snails have attracted researchers from all disciplines but early life stages have received limited attention due to difficulties accessing or rearing juvenile specimens. Here, we document for the first time the culture ofConus magusfrom eggs through metamorphosis to reveal dramatic shifts in predatory feeding behaviour between post-metamorphic juveniles and adult specimens. AdultC. maguscapture fish using a set of paralytic venom peptides combined with a hooked radular tooth used to tether envenomed fish. In contrast, early juveniles feed exclusively on polychaete worms using a unique “sting-and-stalk” foraging behaviour facilitated by short, unbarbed radular teeth and a distinct venom repertoire that induces hypoactivity in prey. Our results demonstrate how coordinated morphological, behavioural and molecular changes facilitate the shift from worm- to fish-hunting inC. magus, and showcase juvenile cone snails as a rich and unexplored source of novel venom peptides for ecological, evolutionary and biodiscovery studies.
Artificial neural network modified heat transfer model for furnace coil rolling of magnesium alloy plate
Authors: Kong Shuping , Ning Fangkun , Ma Lifeng , Jia Weitao , Le Qichi 
Published: October 2022

Abstract
Through the experimental temperature measurement and numerical simulation of veneer and stacked plates with different thicknesses, the heat transfer behavior of magnesium alloy wide plate furnace coil rolling was studied. It found that the radial thermal radiation heat transfer rate of the magnesium alloy coil was greater than the thermal conduction heat transfer rate between the coil layers, and the average heating rate of the outer layer of the coil was about twice that of the middle and inner layers. A dimensionless correction factor λ was introduced to the traditional heat transfer model of magnesium alloy coil rolling process based on artificial neural network (ANN) model. After the modification, the reduced Chi-Spr of the heat transfer models of the coil rolling process was reduced significantly from 6.9195 to 1 nearby. In addition, there was a negative correlation between the plate thickness and the heating rate, and the heating rate of the sheet with a small Biot ( Bi) value to different temperatures varied greatly. The heating rate of the 3.6mm sheet augments with the increase of temperature. The cooling time of the magnesium plate was proportional to the thickness of the plate, and the cooling rate of the plate with a large Bi value varied greatly from distinct initial temperatures. The cooling rate of 6.0mm plate at high temperature was greater than that at low temperature. According to the temperature distinction of different parts of the sheet, the precise cooling model was constructed.
The translatome of Glioblastoma multiforme
Authors: Cornelissen F. M.G. , He A. , Haas R. R. , Houweling M. , Noske D. , Vandertop W. P. , Piersma S. R. , Jiménez CR. , Murre C. , Westerman BA. 
Published: October 2022

Abstract
Background
Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumor, containing intrinsic resistance to current therapies leading to poor clinical outcomes. Therefore, understanding the underlying mechanisms of GBM is an urgent medical need. Although radiotherapy contributes significantly to patient survival, GBMs recur typically within the initial radiation target volume, suggesting remaining GBM cells are highly radioresistant. Deregulation of the protein translation mechanism has been shown to contribute to cancer progression by driving translational control of specific mRNA transcripts involved in cancer cell regulation.
Methods
To identify new potential therapeutic targets for the treatment of GBM we performed ribosome profiling of glioma sphere cultures (GSCs) under normal and radiotherapeutic conditions.
Results
We found that the global translation of genes matched and overlapped with previously published GBM subtypes, based on the transcriptional level. In addition, we revealed a broad spectrum of open reading frame types in both coding and non-coding regions, including a set of lncRNAs and pseudogenes undergoing active translation. In addition, we identified new mRNA transcripts being translated. Finally, we show that translation of histones is downregulated while splicing factors are intensively translated after irradiation of GSCs.
Conclusions
Together, our unprecedented GBM riboprofiling provides new insights in real time protein synthesis in GBM under normal and radiotherapeutic conditions which forms a resource for future research and provides potential new targets for therapy.
Prey choice and ingestion of microplastics by Common Shelducks and Common Eiders in the Wadden Sea World Heritage Site
Authors: Bange Andreas , Backes Anna , Garthe Stefan , Schwemmer Philipp 
Published: October 2022

Abstract
Top predators such as coastal birds are essential components of marine food webs, and understanding their trophic interactions forms an essential basis of food web models. However, at the same time, the proportion of plastic debris in marine food webs has constantly increased while the degree of plastic ingestion by marine birds is still poorly known. In this study, the diets and microplastic uptakes in two numerous benthivorous bird species in the Wadden Sea were examined microscopically, i.e. the common eider (Sommateria mollissima) indicative for the subtidal and the common shelduck (Tadorna tadorna) indicative for the intertidal area. Eiders (n = 42 carcasses; n = 120 faecal samples) mainly ingested common cockles (Cerastoderma edule). Blue mussels (Mytilus edulis) ranged second and – same as the invasive razor clam (Ensis leei) – occurred more frequently than reflected by historic data. Proportions of gastropods, bristle worms and crustaceans were low. Shelducks (n = 20 carcasses; n = 98 faecal samples) fed mainly on small molluscs, especially C. edule and mud snails Peringia ulvae, along with other bivalves, bristle worms and small crustaceans such as amphipods and a few fish and insects. Plastic debris was found in 92.9% of stomachs and 74.2% of faeces from eiders as well as in 95% of the stomachs and 85.7% of the faeces from shelducks. Most plastic consisted of brightly coloured filaments ˂5 mm. These findings indicate regular uptake and excretion of plastic debris by coastal benthivorous seabirds, both in the subtidal and intertidal realm. The origin and mode of uptake of microplastics are discussed.
Advanced Characterization-Informed Framework and Quantitative Insight to Irradiated Annular U-10Zr Metallic Fuels
Authors: Xu Fei , Cai Lu , Salvato Daniele , Dilemma Fidelma , Capriotti Luca , Yao Tiankai 
Published: October 2022

Abstract
U-10Zr-based metallic nuclear fuel is a promising fuel candidate for next-generation sodium-cooled fast reactors. Idaho National Laboratory’s research experience for this type of fuel dates back to the 1960s. Idaho National Laboratory researchers have accumulated a considerable amount of experience and knowledge regarding fuel performance at the engineering scale. The limitation of advanced characterization and lack of proper data analysis tools prevented a mechanistic understanding of fuel microstructure evolution and properties degradation during irradiation. This paper proposed a new workflow, coupled with domain knowledge obtained by advanced post-irradiation examination methods, to provide unprecedented and quantified insights into the fission gas bubbles and pores, and lanthanide distribution in an annular fuel irradiated in the Advanced Test Reactor. In the study, researchers identify and confirm that the Zr-bearing secondary phases exist and generate the quantitative ratios of seven microstructures along the thermal gradient. Moreover, the distributions of fission gas bubbles on two samples of U-10Zr advanced fuels were quantitatively compared. Conclusive findings were obtained and allowed for evaluation of the lanthanide transportation through connected bubbles based on approximately 67,000 fission gas bubbles of the two advanced samples.
Online medical education delivered through the Facebook platform during the COVID-19 pandemic: A qualitative study
Authors: Chambers Joshua , Mistry Khaylen , Spink Joel , Tsigarides Jordan , Bryant Pauline 
Published: October 2022

Abstract
Background:
The COVID-19 pandemic put extreme pressure on higher education institutions in terms of staffing and providing in-person teaching. This pressure provided an opportunity to accelerate the move universities were already making to transitioning large parts of the curriculum online. The Remote Learning project, based in Norfolk, United Kingdom had an aim of supplementing Norwich Medical School (NMS) teaching during the pandemic. It was an online program of asynchronous and synchronous teaching delivered by medical students on Facebook. After the project ended, we investigated the student and tutor perceptions of online learning delivered through the Facebook Social Medica (SoMe) platform.
Methods:
This qualitative study recruited students and tutors from NMS by email, participation was voluntary. Online semi-structured interviews of both students and tutors in the remote learning project were conducted. The data was analysed using thematic analysis.
Results:
In total, 7 participants were interviewed. Students enjoyed the informal synchronous and asynchronous nature of the SoMe platform but were concerned about mixing professional and social platforms and the potential professional implications of this. Tutors enjoyed the comments section and community feel but had concerns about data security of educational material online. Both students and tutors were concerned about distraction and productivity on SoMe.
Conclusions:
The study found that SoMe can be a credible platform to deliver online teaching which has unique benefits such as being free, easy to use and having the potential at breaking down traditional pedological hierarchies. However, it comes with limitations such as a perceived risk of distraction and the mix of professional and social boundaries. Educators should consider the ergonomics of SoMe platforms when designing online curriculums and guidelines should be considered on the use of SoMe in medical education.
A Searchable Encryption Scheme with Hidden Search Pattern and Access Pattern on Distributed Cloud System
Authors: Duan Shengchen , Liu Hong , Gu Lize 
Published: October 2022

Abstract
Dynamic searchable encryption methods allow a client to perform searches and updates over encrypted data stored in the cloud. However, existing researches show that the general dynamic searchable symmetric encryption (DSSE) scheme is vulnerable to statistical attacks due to the leakage of search patterns and access patterns. Although the traditional Oblivious Random Access Machine (ORAM) can hide the access pattern, it also incurs significant communication overhead and cannot hide the search pattern. To overcome this limitation, a DSSE scheme called obliviously shuffled incidence matrix DSSE (OSM-DSSE) is proposed in this paper to access the encrypted data obliviously without using ORAM. The OSM-DSSE scheme realizes efficient search and update operations based on an incidence matrix. In particular, a shuffling algorithm using Paillier encryption combines the 1-out-of-n obliviously transfer (OT) protocol to hide access pattern and an optimized padding scheme to obfuscate the search pattern with small storage overhead. Besides, a formalized security analysis and performance analysis of the proposed scheme is provided, which indicates that the OSM-DSSE scheme achieves high security, efficient searches, and low storage overhead. Also, this scheme not only completely hides the search and access patterns but also provides adaptive security against malicious attacks by adversaries. Furthermore, experimental results show that the OSM-DSSE scheme obtains 3-4x better execution efficiency than the state-of-art solutions.