bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative Electroencephalography Findings in Treatment- resistant and Responsive Patients with Idiopathic Generalized Tonic-Clonic Epilepsy
Authors: Shaafi Sheida , Nasibi Seyede Maryam , Chalabianloo Gholamreza , Nejadghaderi Seyed Aria 
Published: October 2022

Abstract
Background: With roughly 50 million people affected in the world, epilepsy is a particularly important disorder of the brain commonly diagnosed based on findings of quantitative electroencephalography (QEEG). The present investigation was aimed to evaluate differences in QEEG readings of drug-resistant and drug-responsive patients with idiopathic generalized epilepsy (IGE) with tonic-clonic seizures in a northwestern Iranian population.
Methods: A total of 60 participants, consisting of 30 drug-resistant and 30 drug-responsive patients with IGE, were enrolled. Data, including demographic information and Z-transformed absolute power values of QEEG in anterior, central and posterior alpha, beta, delta and theta bands were collected. The analysis was conducted using IBM SPSS and a p-value<0.05 was considered as statistically significant.
Results: Of the 60 participants with a mean age of 31.55 ± 10.48, 41 (68.3%) were female and 19 (31.7%) were male. Statistically significant differences were observed in anterior alpha, beta and theta bands, central alpha, beta, delta and theta bands, and posterior beta, delta and theta bands between the two groups, with the absolute power Z-scores of drug-resistant group being significantly higher than the other (P-values<0.05). Abnormal EEGs were recorded for 16 (53.3%) and 5 (23.8%) patients from the drug-resistant and drug-response groups, respectively, indicating a significant difference (P-value=0.006). Female patients were more likely to have drug-resistant disease than male participants (P-value=0.003).
Conclusions: QEEG is a valuable diagnostic test for prognostication of patients with IGE, or follow-up of patients with regards to their treatment. QEEGs with normal readings indicate a more favorable prognosis, compared with those containing abnormal findings.
Catalytic Valorisation of Sugarcane Bagasse to Energy Carriers
Authors: Anekwe Ifeanyi Michael Smarte , Mustapha Sherif Ishola , Isa Yusuf Makarfi 
Published: October 2022

Abstract
Sustainable processes have continued to be of interest to both academia and industries. The sugar industry in this regard has explored the potential of using sugar cane bagasse as a fuel within the industry so as to enhance the economics of the process. In addition to its fuel potential, bagasse has the prospects of being converted to chemical compounds that could serve as both raw materials as well as energy carriers. In this work, we investigated the potential of adding value to sugarcane bagasse by catalytic and non-catalytic thermal conversion processes; hydrothermal liquefaction (HTL) and pyrolysis. HZSM-5 was used as a catalyst for both the hydrothermal liquefaction and pyrolysis processes. The HTL operating temperature and heating times were varied between 220–373°C and 30–60 mins respectively while the catalyst type, reactor volume loading and feedstock to water ratio remained fixed. The pyrolysis was carried out at temperatures of 400°C, 450°C and 500°C and the effect of catalyst to biomass (0.1:1 g/g, 0.25:1 g/g and 0.5:1 g/g) on the product yield and distribution was also investigated. The results showed that various compounds were obtained as the hydrothermal conditions were varied. Interestingly, the aliphatic hydrocarbons were relatively lower in concentration when compared to the substituted hydrocarbons. The highest amount of hydrocarbons (a little over 6 wt. %) was obtained when the bagasse was hydrothermally converted using a catalyst at 300°C for 45 minutes. Esters accounted for about 80 wt. % when the process was carried out at 373°C and 45 minutes in the presence of ZSM-5, this is more than double the amount obtained when the same conditions were used in the absence of a catalyst. Findings from this study also revealed that the bio-oil yield was significantly affected by pyrolysis temperature and catalyst to feedstock ratio. A higher yield of pyrolytic bio-oil and higher conversion of sugarcane bagasse was produced with the HZSM-5 catalyst when compared to the non-catalytic pyrolysis process. Aromatization of produced bio-oil was enhanced by the higher catalyst loading during the pyrolysis of sugarcane bagasse.
In situ diffraction monitoring of nanocrystals structure evolving during catalytic reaction at their surface
Authors: Zieliński Maciej , Kaszkur Zbigniew , Juszczyk Wojciech , Sobczak Janusz 
Published: October 2022

Abstract
With decreasing size of crystals the number of their surface atoms becomes comparable to the number of bulk atoms and their powder diffraction pattern becomes sensitive to a changing surface structure. On the example of nanocrystalline gold supported on also nanocrystalline CeO2 we show evolution of (a) the background pattern due to chemisorption phenomena, (b) peak positions due to changing concentration profile of O within nonstoichiometric CeO(2−x) particles, (c) Au peak intensity due to transport phenomena of gold atoms to the surface of ceria, varying amount of Au in the crystalline form. The results of the measurements, complemented with mass spectrometry gas analysis, point to a multiply twinned structure of gold, its high mobility and repeatable peak position on exposure to He-X-He when X is O2 , H2 ,CO or CO oxidation reaction mixture, suggesting no ceria lattice oxygen being consumed/supplied at any stage of the process. The work shows possibility of structurally interpreting different contributions to the multi-phase powder diffraction pattern during a complex physico-chemical process, including effects of physi- and chemisorption. It shows a way to structurally interpret surface evolution during a catalytic reaction involving no bulk phase transition.
Parallel synthesis of condensed pyrimidine-thiones and their antitumor activities
Authors: Song Buer , Nie Lifei , Bozorov Khurshed , Kuryazov Rustamkhon , Aisa Haji Akber , Zhao Jiangyu 
Published: October 2022

Abstract
Herein we studied the formation of thiones via C=O group conversion into the C=S functional group-based tricyclic pyrimidinone systems using Lawesson’s reagent and phosphorus pentasulfide as thionation agents. Naturally-occurring alkaloids deoxyvasicinone and mackinazolinone were selected as templates for the modification of furo[2,3-d]pyrimidinone and pyrrolo[2,3-d]pyrimidinone scaffold. Research work was performed under the combinatorial and parallel synthesis of pyrimidine-based small molecules, along with a one-pot reaction strategy. All synthesized 54 novel pyrimidine-thiones were elucidated by 1H-NMR, 13C-NMR, and HRMS analysis. In addition, both series of thiones were evaluated for their antitumor activity against three types of the human cancer cell: cervical HeLa, breast MCF-7, and colon HT-29 lines. Compound with azepine fragment 13aa (1-methyl-2-(4-(trifluoromethyl)phenyl)-1,6,7,8,9,10-hexahydro-4H-pyrrolo[2',3':4,5]pyrimido[1,2-a]azepine-4-thione) was most active derivative (IC50=2.09±0.22 µM) against the HT-29 cell line.
Effect of preconditioner conditions and soybean meal substitution with sunflower meal on the chemical composition of the commercial freshwater fish extrudates
Authors: Suloma Ashraf , Abdel-Salam Sameh , Kaddour Osama , Mabroke Rania Said , Abd-Elhamed Mohamed 
Published: October 2022

Abstract
The aim of the present study was to evaluate the combined effect of the preconditioner conditions and substitution soybean meal protein with sunflower meal protein on the chemical composition of freshwater fish feeds. This experiment was conducted using Box-Behnken design with three independent variables; i) substitution of soybean meal with sunflower meal at three levels 0, 25 and 50%, ii) preconditioner temperature at three levels of 85, 95 and 105 °C, iii) preconditioner moisture (15,17.5 and 20%). There was no significant effect of manipulating the level of the three independent variables on the extrudates crude protein, crude fat, ash level and trypsin inhibitor activity. Increasing the substitution of soybean meal by sunflower meal significantly increased the extrudates dry matter and crud fiber levels. Increasing the preconditioner temperature had no negative effects on all the essential amino acids levels with exception of the threonine level, while significant increase in arginine, histidine and alanine levels of the extrudates were observed. Increasing sunflower meal inclusion had a negative significant effect on lysine and tyrosine levels and had a significant positive effect on methionine and glycine levels. These results indicate that increasing of the preconditioner temperature has a positive effect on increasing the inclusion level of sunflower meal in freshwater fish diets.
Production of a herbal drink by spray drying of mixed purple basil extract- lemon juice; formulation, process optimization, and characterization
Authors: Avazsoofian Abdolsattar , Gülmez Handan Başünal , Topuz Ayhan , Malekjani Narjes , Jafari Seid Mahdi 
Published: October 2022

Abstract
In this study, the possibility of producing mixed purple basil-lemon juice powder as an herbal drink by the spray drying was explored. The purple basil extract and lemon juice were mixed in a ratio of 65:35 (% v/v), and the process variables including inlet air temperature (110–190°C) as well as the concentrations of maltodextrin (MD) and gum Arabic (GA) as carriers were optimized. The spray dried powder was characterized in terms of the moisture content, water activity, water solubility, product yield, particle size, total monomeric anthocyanins, and volatile components. The results indicated that both air temperature and MD/AG ratio had a significant effect on final powder properties except for aw. The optimum conditions for maximizing encapsulation efficiency and powder yield while keeping other factors in a suitable range were inlet temperature of 146°C, 9.68%, MD, and 5.32% GA. Moreover, the GC-MS data revealed that the predominant aroma components in the final powder, lemon juice, and the reconstituted product were limonene and γ-terpinene; limonene; γ-terpinene, linalool, and 1.8 cineole, respectively. Overall, these results demonstrated that spray drying using AG/MD blends was feasible, improving the consolidation of bioactive compounds of purple basil and lemon juice in powdered form.
Elucidation of the metabolic mechanism for malate production in Myceliophthora thermophila via 13C metabolic flux analysis
Authors: Jiang Junfeng , Liu Defei , Tian Chaoguang , Xia Jianye 
Published: October 2022

Abstract
Background
Myceliophthora thermophila has been engineered to be an important cell factory for malic acid production, however detail information on how carbon fluxes are distributed in the high production strain is still not clear. 13C-MFA (13C metabolic flux analysis) can help to understand cellular metabolic mechanisms and identify important targets for deciphering the carbon flux distribution and improving product synthesis. Here, we used 13C-MFA to study metabolic flux distribution of high malate production strain of M. thermophile for the first time.
Results
Higher glucose uptake and carbon dioxide release rate, together with lower oxygen consumption rate and biomass yield was found in malate high production strain M. thermophila JG207 compared to the wild strain. Corresponding to the above phenotypes, it is found that in JG207 both pentose phosphate pathway flux and oxidative phosphorylation flux decreased, while TCA downstream flux increased. Higher PPP flux in WT strain accompanied with higher energy state, and corresponding high ATP concentration inhibited glucose-6-phosphate isomerase activity. Several intermediates of reduced TCA pathway in JG207 were accumulated due to high reduction power state, which benefits the conversion of oxalate to malate. The reduced flux of oxidative phosphorylation is shown to be able to cover extra supply of NADH for high malate production.
Conclusions
This work revealed the intracellular metabolic fluxes distribution for the high malic acid production strain M. thermophile JG207 for the first time. The flux distribution results showed that higher NADH supply was of high importance for higher accumulation of malic acids, this may be guidance for further improvement of the productivity.
Different definitions of feeding intolerance and their associations with outcomes of critically ill adults receiving enteral nutrition: a systematic review and meta-analysis
Authors: Li Jianbo , Wang Lijie , Zhang Huan , Zou Tongjuan , Kang Yan , Liao Xuelian , He Wei , Xu Yuan , Yin Wanhong 
Published: October 2022

Abstract

Background A unified clinical definition of feeding intolerance (FI) is urged for better management of enteral nutrition (EN) in critically ill patients. We summarized the comprehensive evidence for the associations of different FI definitions with patient-centered outcomes. Methods This systematic review and meta-analysis included searches of PubMed, Web of Science, the Cochrane Library, ClinicalTrials.gov, and several Chinese medical databases from inception to April 26, 2022, for clinical studies comparing FI with non-FI premised on a clear FI definition and patient-centered outcomes in critical illness adults receiving EN. We summarized the evidence by random-effect meta-analyses and rated the certainty of evidence by the Grading of Recommendations Assessment, Development, and Evaluation frameworks. Results 5525 records were identified by our search, of which 26 studies enrolled 25189 adult patients. Except for all-cause long-term mortality and mechanical ventilation days, all patient-centered outcomes were associated with FI. Moderate to low certainty evidence established FI defined as large gastric residual volume (GRV) combined with any other gastrointestinal symptoms (GISs) had a significant association with high mortalities in particular all-cause intensive care unit (ICU) mortality (odds ratio [OR] 2.29, 95% confidence interval [CI] 1.98 to 2.65) and prolonged length of ICU stay (mean difference 4.21, 95% CI 2.52 to 5.90), with a moderate ICU prevalence (40.36%, 95% CI 33.73–46.99%). GRV ≥ 500 ± 50 mL (24-hour cumulative) alone had a higher risk of all-cause ICU mortality (OR 2.58, 95% CI 2.08 to 3.19) but with a low ICU prevalence (11.25%, 95% CI -10.3–32.79%) while enteral feeding (EF) percentage < 80% had a higher ICU prevalence (50.29%, 95% CI 14.25 to 86.32) but a marginally significant association with all-cause ICU mortality (OR 1.87, 95% CI 1.08 to 3.24) as overlapping the prespecified upper limit value for the minimally important difference of 1.2 times the baseline risk. Conclusions In critically ill adult patients receiving EN, the large-GRV-centered GISs to define FI proved superior to EF-based or large GRV alone in terms of both close associations with all-cause ICU mortality and acceptable ICU prevalence. The study was registered with PROSPERO: CRD42022326273. Registered 10 May 2022.
Harsh Parenting and Suicide Ideation among Chinese Adolescents: The Roles of Self-esteem and School Social Support
Authors: Zhao Jingfei , Wang Yulong 
Published: October 2022

Abstract
While negative parenting style has considered as a risk factor for suicide ideation, little attention has been given to the mechanisms between harsh parenting and suicide ideation. This study explored the mechanism underlying the relationship between harsh parenting and suicide ideation among Chinese adolescents. Participants were 4189 Chinese adolescents who completed measures of harsh parenting, school social support, self-esteem, and suicide ideation. The results demonstrated that beyond the direct impact of harsh parenting on adolescent suicide ideation, harsh parenting also indirectly contributed to adolescent suicide ideation via the mediator of adolescents’ self-esteem. School social support moderated the relationship between harsh parenting and self-esteem as well as the relationship between self-esteem and suicide ideation. The buffering effect of school social support is limited as risk increasing. The findings suggest potential pathways for suicide prevention and intervention strategies.
Stability Classification of Stock Market Using Temporal Rule-Based Classification
Authors: Fattah Polla , Aickelin Uwe , Wagner Christian , Rashid Tarik A. , Alsadoon Abeer , Bacanin Nebojsa 
Published: October 2022

Abstract
Economists have sought to predict stock market prices for decades with varying degrees of success. This study classifies stocks according to their stability in two consequent financial quarters (depending on whether the majority of stocks remain in the same stability group, which can indicate forecastability). However, classifying temporal information like stock market data using available methods produces complicated rules that cannot be easily interpreted by human experts. To reduce this complication a new approach of rule-based temporal classification is used. The method combines human-provided rules with machine optimisation to produce classes that can be easily interpreted by experts, enabling them to comprehend the complicated temporal dimension of the data. Rules provided by human experts might be via generalization of the temporal data using statistical functions like standard deviation and averages. Initially, each rule will have a range of possible values that can be reduced to a single one. For this study, we classify the stability of stock market data of the S&P 500 for two constitutive financial quarters to test if stocks have the same stability or not. The results show that the classes for stock markets are different beyond random chance, which might be an indication of the viability of forecasting stock markets depending on their old trends.
A Novel Model Based on Immune-Related Genes for Differentiating Biliary Atresia from Other Cholestatic Diseases
Authors: 李 腾飞 , Zheng Qipeng , Zhang Ruifeng , Liu Shaowen , Lin Yuda , Zhan Jianghua 
Published: October 2022

Abstract
Purpose
Based on a public gene expression database, this study established the immune-related genetic model that distinguished BA from other cholestasis diseases (DC) for the first time. We explored the molecular mechanism of BA based on the gene model.
Methods
The BA microarray dataset GSE46960, containing BA, other cause of intrahepatic cholestasis than biliary atresia and normal liver gene expression data, was downloaded from the Gene Expression Omnibus (GEO) database. We performed a comprehensive bioinformatics analysis to establish and validate an immune-related gene model and subsequently identified hub genes as biomarkers associated with the molecular mechanisms of BA. To assess the model's performance for separating BA from other cholestasis diseases, we used receiver operating characteristic (ROC) curves and the area under the curve (AUC) of the ROC. Independent datasets GSE69948 and GSE122340 were used for the validation process.
Results
The model was built using eight immune-related genes, including EDN1, HAMP, SAA1, SPP1, ANKRD1, MMP7, TACSTD2, and UCA1. In the GSE46960 and validation group, it presented excellent results, and the prediction accuracy of BA in comparison to other cholestasis diseases was good. Functional enrichment analysis revealed significant immunological differences between BA and other cholestatic diseases. Finally, we found that the TNFα- NF-κB pathway is associated with EDN1 gene expression and may explain fibrosis progression, which may become a new therapeutic target.
Conclusion
In summary, we have successfully constructed an immune-related gene model that can distinguish BA from other cholestatic diseases, while identifying the hub gene. Our exploration of immune genes provides new clues for the early diagnosis, molecular mechanism, and clinical treatment of biliary atresia.
A Novel Recommender System Using PSO, FCM and, Autoencoder
Authors: Verma Om Prakash , Beniwal Nidhi 
Published: October 2022

Abstract
The recommender system is the most developing application in the web environment. A good Recommendation system needs to make choices and decisions to provide recommendations to the user. The Recommender system filters the information and provides accurate recommendations of products or services for a concerned individual. In this research, we propose a model, which employs three approaches; clustering, nature-inspired optimizer, and deep learning. The fuzzy c-means clustering technique is combined with the particle swarm optimization algorithm. The particle swarm optimizer works as a feature extractor. The particle swarm optimizer is applied to the Movielens dataset to get the initial cluster positions. The fuzzy c-means is used to classify the users in the dataset and to reduce data redundancy. The optimized and clustered data is provided as input to the autoencoder to get the final recommendations of the movies to the users. We have proposed our recommender system in two parts; 1) Using a single-layer autoencoder, and 2) Using a deep autoencoder. We analyzed our proposed system over a publicly available dataset- Movielens. The proposed system is compared with the existing recommender systems. The experimental results of our system revealed that the performance and efficiency are improved, and offered better recommendations.
· Integrated metabolic and transcriptomic profiles reveal the germination-associated dynamic changes for Cassiae Semen
Authors: Chen Biying , Shi Biru , Ge Xiaoyan , Fu Zhifei , Yu Haiyang , Zhang Xu , Liu Caixiang , Han Lifeng 
Published: October 2022

Abstract
Introduction The seeds of Cassia obtusifolia L. (Cassiae Semen) have been widely used as both food and traditional Chinese medicine in China.
Objectives For better understanding the metabolic mechanism along with germination, different samples of Cassiae Semen at various germinating stages were collected.
Methods These samples were subjected to 1H-NMR and UHPLC/Q-Orbitrap-MS based untargeted metabolomics analysis together with transcription analysis.
Results A total of fifty differential metabolites (mainly amino acids and sugars) and twenty key genes involved in multiple pathways were identified in two comparisons of different groups (36 h vs 12 h and 84 h vs 36 h). The metabolic and gene network for seed germination was depicted. In the germination of C. Semen, the fructose and mannose metabolism pathway was activated, indicating energy was more needed in the testa rupture period (36 h). In the embryonic axis elongation period (84 h), the pentose and glucuronate interconversions pathway, and phenylpropanoid biosynthesis pathway were activated, which suggested some nutrient sources (nitrogen and sugar) would be demanded. Furthermore, oxygen, energy and nutrition should be supplied through the whole germination process. These global views open up an integrated perspective for understanding the complex biological regulatory mechanism during seed germination process of C. Semen.