bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical expression of microRNA‐144‐5p and its regulatory effect on renal function in uremia
Authors: Zang Dong , Li Junyi , Zhou Chuanyan 
Published: August 2022

AbstractObjectiveThe study commits to probing the clinical expression of microRNA‐144‐5p (miR‐144‐5p) and its modulatory effect on the renal function of uremia.MethodsLevels of blood urea nitrogen (BUN), β2‐microglobulin (β2‐MG), serum creatinine (Scr), blood calcium (Ca), phosphorus (P), and intact parathyroid hormone (iPTH) and miR‐144‐5p expression in serum of uremia patients were detected. The correlation among miR‐144‐5p expression with BUN, β2‐MG, Scr, Ca, P, and iPTH levels in uremic patients was analyzed. The rats were injected with miR‐144‐5p agomir to detect the change of BUN, Scr, β2‐MG, Scr, Ca, P, and iPTH levels in uremic rats.ResultsmiR‐144‐5p expression in uremic patients was negatively correlated with BUN, Scr, β2‐MG, P, and iPTH levels, and positively correlated with free Ca concentration in blood. miR‐144‐5p elevation reduced BUN, Scr, β2‐MG, P, and iPTH levels, and increased free Ca concentration in blood in uremic rats.ConclusionmiR‐144‐5p is lowly expressed, and miR‐144‐5p has a regulatory effect on renal function in uremia.
Development of a Field Scale SWAT+ Modeling Framework for the Contiguous U.S.
Authors: White Michael J. , Arnold Jeffrey G. , Bieger Katrin , Allen Peter M. , Gao Jungang , Čerkasova Natalja , Gambone Marilyn , Park Seonggyu , Bosch David D. , Yen Haw , Osorio Javier M. 
Published: August 2022

ABSTRACTThe Soil and Water Assessment Tool (SWAT) model is commonly used to predict the impacts of agricultural practices on water quality and quantity. Although widely applied, the data framework used to drive SWAT in the United States (U.S.) is fragmented and inconsistent, varying by user and model interface. This research describes the development of the National Agroecosystems Model (NAM), which provides a unified field to national scale modeling computational framework for research and decision support by using the latest SWAT platform, dubbed SWAT+. NAM has sufficient detail to capture field‐level processes and management actions and spans the full extent of the contiguous U.S. NAM contains 7 million computational units, 4 million of which represent specific cultivated fields. It contains 3 million individually identifiable stream segments and more than 5,000 reservoirs. NAM is intended to serve as a reasonable base framework to be refined for specific applications. This work describes the individual data sources, assumptions, and the processing steps for their inclusion. NAM is constructed with 2,121 individual SWAT+ models which can be executed in a parallel hierarchical structure to dramatically improve runtime. This framework was tested in a case study of the Little River Watershed, Tifton, GA. NAM is developed using only publicly available data sources such that subsets of it can be shared to support research with other government agencies, universities, and others in the public domain.
Accrual‐Based Earnings Management and Regulation: A Literature Review*
Authors: Greusard Olivier 
Published: August 2022

ABSTRACTThis paper reviews how the accounting literature has investigated accrual‐based earnings management (AEM) in relation to regulation. After describing the development of accrual‐based models to measure earnings management, I provide evidence that the accounting literature has investigated AEM and regulation to answer six types of research questions. First, researchers investigate whether firms manage earnings before a regulatory event to benefit from it or to avoid its negative consequences. Second, they look at whether firms engage in AEM after the implementation of a new regulation to avoid the regulatory costs associated with lack of compliance or to respect regulatory industry ratios. Third, researchers use accruals quality metrics to investigate the change in quality of accounting after a change in regulation. Fourth, they use accruals quality metrics to analyze the impact of differences between regulatory environments. Fifth, researchers exploit Accounting and Auditing Enforcement Releases to clearly identify samples of low‐quality firms in order to develop new earnings management models, test the specifications of existing models, or identify new patterns linked to earnings management. Sixth, the accounting literature employs regulation to investigate potential complementarity or substitution effects between accrual‐based and real earnings management. I also discuss how the emergence of new technologies such as machine learning, the ongoing debate between single‐accrual and aggregate models, regulatory events other than laws, and recent regulations create opportunities for future research into AEM in relation to regulation.
Red turpentine beetle primary attraction to β‐pinene or 3‐carene (with and without ethanol) varies in western US pine forests
Authors: Kelsey Rick G. , Westlind Douglas J. , Gaylord Monica L. 
Published: August 2022

Abstract
Lure attraction strength for red turpentine beetle, Dendroctonus valens (Coleoptera: Curculionidae: Scolytinae) observed previously in US Pacific Northwest ponderosa pine forests is (−)‐β‐pinene+ethanol > (+)‐3‐carene+ethanol, but untested elsewhere in its western US range. Thus, both were tested with (−)‐β‐pinene, (+)‐3‐carene, ethanol, and a blank in Oregon and California sites burned by wildfire, whereas in Arizona the first four lures were tested in a thinned‐unburned site.
The D. valens responses in burned Oregon and California sites were similar, (−)‐β‐pinene+ethanol > (−)‐β‐pinene > 3‐carene = 3‐carene+ethanol > ethanol > blank, whereas in the cut‐unburned Arizona site it was 3‐carene+ethanol > 3‐carene = (−)‐β‐pinene+ethanol > (−)‐β‐pinene. Whether this variation was influenced by beetle genetic differences, or chemical and physical parameters in the different environments and remaining stressed host resources 1‐year post disturbance warrants additional study.
Responses to (−)‐β‐pinene varied, from a stronger attractant than (+)‐3‐carene in Oregon and California, to a weaker lure than (+)‐3‐carene in Arizona. This (−)‐β‐pinene variability was minimized when released in combination with ethanol, making (−)‐β‐pinene+ethanol the most consistent attractant of those tested across the three states, and a reliable lure for detection, monitoring, and management projects for D. valens in western US pine forests.
Effects of transitional care based on the social support theory for older patients with osteoporotic vertebral compression fractures: A quasi‐experimental trial
Authors: Yang Wenwen , Xu Haiyan , Miao Weiwei , Geng Zihan , Geng Guiling 
Published: August 2022

AbstractObjectivesThis study aimed to investigate the effects of transitional care (TC) programs on the health outcomes of discharged older patients with osteoporotic vertebral compression fractures (OVCFs).MethodsA total of 160 older patients were recruited from two campuses of a public teaching hospital in China. Patients were grouped according to the campus to which they were admitted. The TC programs commenced one day before discharge and lasted 6 months after discharge. Repeated‐measures analysis of variance was used to analyse the effects of the TC programs.ResultsThe TC programs improved the discharge of older patients with OVCF in their activities of daily living (ADLs), pain levels and social support, and decreased fracture recurrence rates.ConclusionsThis study provides evidence of concurrent clinical improvements and health outcomes in discharged older patients with OVCFs from the effects of TC programs based on social support theory.
Internal mammary node involvement in patients with axilla‐negative early breast cancer: a narrative review
Authors: Braue Kaela , Baker Caroline , Lippey Jocelyn 
Published: August 2022

AbstractEarly breast cancer staging involves radiological and pathological evaluation of the tumour and regional lymph nodes. The internal mammary nodes (IMN) are an important site of possible metastasis and influence disease stage and prognosis. However, the recommendation for routine IMN assessment remains unclear. Internal mammary sentinel lymph node biopsy (SLNB) is associated with increased morbidity and an unknown survival benefit. Furthermore, the IMN are traditionally thought to be involved only synchronous with, or following, axillary node (AXN) metastasis. The aim of this review is to determine the prevalence of IMN metastasis in patients with axilla‐negative early breast cancer. A narrative review of studies assessing IMN metastasis was performed. The literature search was completed using the database Medline (Ovid). Twenty‐two retrospective studies were identified. The studies included data from SLNB, US, MRI, PET/CT and opportunistic biopsy during free‐flap reconstruction (FFR). The prevalence of isolated IMN metastasis ranged from 1.2% to 17.9%.
Editorial: thiopurines in the multidrug era—time to rescue our memories over half a century of experience. Authors' reply
Authors: Rezazadeh Ardabili Ashkan , Jeuring Steven , Mujagic Zlatan , Oostenbrug Liekele , Romberg‐Camps Mariëlle , Jonkers Daisy , Van Bodegraven Adriaan , Pierik Marieke 
Published: August 2022

LINKED CONTENTThis article is linked to Rezazadeh Ardabili et al papers. To view these articles, visit https://doi.org/10.1111/apt.17128 and https://doi.org/10.1111/apt.17164
Cardiovascular complications of modern multiple myeloma therapy: A pharmacovigilance study
Authors: Al‐Yafeai Zaki , Ghoweba Mohamed , Ananthaneni Anil , Abduljabar Hamzah , Aziz David 
Published: August 2022

AimsMultiple myeloma accounts for over 10–15% of haematological malignancies. Continued molecular advances have resulted in the development of new drugs for treatment of multiple myeloma. Four drugs were approved by the Food and Drug Administration (FDA) in 2015, but their safety is not well defined. The aim of this study is to delineate the cardiovascular adverse events of these drugs.MethodsWe reviewed the adverse cardiac events of newly approved FDA drugs since 2015 using the US FDA Adverse Events Reporting System (FAERS) database. We calculated the reporting odds ratio (ROR) with 95% confidence interval (CIs) for the drugs that have the highest incidence of cardiovascular adverse events.ResultsAmong the medications that have approved for multiple myeloma between 2015 and 2020, 4 novel drugs showed the highest incidence of cardiotoxicity. ROR (95% CI) for atrial fibrillation due to elotuzumab, ixazomib, daratumumab and panobinostat compared to other FAERS drugs was 5.8 (4.4–7.7), 1.9 (1.5–2.3), 4.8 (4.2–5.6) and 5.7 (4.1–8.1), respectively. The ROR (95% CI) for cardiac failure was 8.2 (6.4–10.5), 4.7 (4.1–5.4), 5.8 (4.9–6.7) and 5.6 (3.8–8.1) and ROR (95% CI) for coronary disease was 2.7 (1.9–3.9), 2.7 (2.3–3.2), 2.3 (1.9–2.8) and 4.6 (3.2–6.6) due to elotuzumab, ixazomib, daratumumab and panobinostat compared to all other drugs in FAERS.ConclusionOur results demonstrated that certain newly approved antimyeloma therapies are significantly associated with previously unknown cardiotoxicity. These results warrant further studies and highlight the importance of considering the cardiac history of patients with multiple myeloma when utilizing these novel agents.
Insights from a pharmacometric analysis of HDMTX in adults with cancer: Clinically relevant covariates for application in precision dosing
Authors: Ibarra Manuel , Combs Ryan , Taylor Zachary L. , Ramsey Laura B. , Mikkelsen Torben , Buddington Randal K. , Heldrup Jesper , Barreto Jason N. , Guscott Martin , Lowe Jennifer , Hurmiz Charles , Marada Suresh , Howard Scott C. , Schaiquevich Paula 
Published: August 2022

AimsHigh‐dose methotrexate (HDMTX) is an essential part of the treatment of several adult and paediatric malignancies. Despite meticulous supportive care during HDMTX administration, severe toxicities, including acute kidney injury (AKI), may occur contributing to patient morbidity. Population pharmacokinetics provide a powerful tool to predict time to clear HDMTX and adjust subsequent doses. We sought to develop and validate pharmacokinetic models for HDMTX in adults with diverse malignancies and to relate systemic exposure with the occurrence of severe toxicity.MethodsAnonymized, de‐identified data were provided from 101 US oncology practices that participate in the Guardian Research Network, a non‐profit clinical research consortium. Modelled variables included clinical, laboratory, demographic and pharmacological data. Population pharmacokinetic analysis was performed by means of nonlinear mixed effects modelling using MonolixSuite.ResultsA total of 693 HDMTX courses from 243 adults were analysed, of which 62 courses (8.8%) were associated with stage 2/3 acute kidney injury (43 stage 2, 19 stage 3). A three‐compartment model adequately fitted the data. Time‐dependent serum creatinine, baseline serum albumin and allometrically scaled bodyweight were clinically significant covariates related to methotrexate clearance. External evaluation confirmed a satisfactory predictive performance of the model in adults receiving HDMTX. Dose‐normalized methotrexate concentration at 24 and 48 hours correlated with AKI incidence.ConclusionWe developed a population pharmacometric model that considers weight, albumin and time‐dependent creatinine that can be used to guide supportive care in adult patients with delayed HDMTX elimination.
T(w)alking responsibility: A case ofCSRperformativity during the COVID‐19 pandemic
Authors: Letiche Hugo , De Loo Ivo , Moriceau Jean‐Luc 
Published: August 2022

AbstractThis paper centers on a case study of CSR performativity during the COVID‐19 pandemic. In the extant CSR literature, CSR performativity has focused on “walking the talk” and/or “talking the walk,” wherein narrative and action around CSR are typically treated as two different things with their relationships questioned. We focus on what has been called “t(w)alking” wherein speech is understood to be performative and wherein speech acts and CSR are merged, becoming one and the same thing. Performativity then entails what is (and what is not) said, whereby CSR involves taking responsibility for speech and/or silences. Our thesis is that the COVID‐19 pandemic led to the “presenting” of CSR as performativity, in the presence of Levinas' Other, as noble (speech) acts. We examine what became of CSR performativity in a for‐profit medical services provider when the COVID‐19 pandemic turned fatal for its main client group: the infirm elderly. The performativity of the statement: “The elderly and their carers must be protected” turned out to be crucial and set the stage for the provider's emergency action. Following on insights derived from Nietzsche and Levinas, and more specifically from their views on the particularity of ethical action, we find that CSR morphed into ethical performativity in the case study at hand. Against the backdrop of the views of these thinkers, the research potential of the performativity of “t(w)alking” in future CSR studies emerges and is critically discussed.
Persons and women, not womb‐givers: Reflections on gestational surrogacy and uterus transplantation
Authors: Cavaliere Giulia 
Published: August 2022

AbstractIn a recent article in this journal, Alex Mullock, Elizabeth Chloe Romanis and Dunja Begović provide an analysis of gestational surrogacy and uterus transplantation (UTx) from the perspective of those who may decide to act as gestational surrogates and womb donors, referred to as ‘womb‐givers’. In this article, I advance two sets of claims aimed at critically engaging with some aspects of their analysis. Firstly, I argue that the expression ‘womb‐givers’ obscures the biologically, socially and politically salient issue that those who engage in these practices are primarily persons and women. My contention is that this is of substance in discussions of the burdens and benefits of gestational surrogacy and UTx, which need to consider the specific position that women occupy in society, and the hierarchies that mediate their lives, experiences and preferences. Second, I argue that, if one were to take seriously the experiences and preferences of the women who may engage in these practices, and their bodily autonomy, then gestational surrogacy and UTx should be regarded as biologically and sociopolitically incommensurable. Mullock et al. overlook important aspects of gestational surrogacy, such as the embodied nature of pregnancy and childbirth, the sociopolitical significance of these experiences, and the often‐oppressive social norms that shape them. Whilst biology is not destiny, I suggest that it is socially and politically ‘sticky’ when it comes to this significance and norms, especially within the sphere of reproduction. Towards the end of the article, I query the authors' conceptualisation of bodily autonomy and of the instruments that enable its respect and promotion.
The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation
Authors: Yu Li , Maishi Nako , Akahori Erika , Hasebe Akira , Takeda Ryo , Matsuda Aya Yanagawa , Hida Yasuhiro , Nam Jin‐Min , Onodera Yasuhito , Kitagawa Yoshimasa , Hida Kyoko 
Published: August 2022

AbstractRecent studies have demonstrated a relationship between oral bacteria and systemic inflammation. Endothelial cells (ECs), which line blood vessels, control the opening and closing of the vascular barrier and contribute to hematogenous metastasis; however, the role of oral bacteria‐induced vascular inflammation in tumor metastasis remains unclear. In this study, we examined the phenotypic changes in vascular ECs following Streptococcus mutans (S. mutans) stimulation in vitro and in vivo. The expression of molecules associated with vascular inflammation and barrier‐associated adhesion was analyzed. Tumor metastasis was evaluated after intravenous injection of S. mutans in murine breast cancer hematogenous metastasis model. The results indicated that S. mutans invaded the ECs accompanied by inflammation and NF‐κB activation. S. mutans exposure potentially disrupts endothelial integrity by decreasing vascular endothelial (VE)‐cadherin expression. The migration and adhesion of tumor cells were enhanced in S. mutans‐stimulated ECs. Furthermore, S. mutans‐induced lung vascular inflammation promoted breast cancer cell metastasis to the lungs in vivo. The results indicate that oral bacteria promote tumor metastasis through vascular inflammation and the disruption of vascular barrier function. Improving oral hygiene in patients with cancer is of great significance in preventing postoperative pneumonia and tumor metastasis.
Association between sodium–glucose co-transporter 2 inhibitors and risk of psoriasis in patients with diabetes mellitus: a nationwide population-based cohort study
Authors: Ma Sheng-Hsiang , Wu Chun-Ying , Lyu Ying-Syuan , Chou Yiing-Jenq , Chang Yun-Ting , Wu Chen-Yi 
Published: August 2022

Abstract

Background
Sodium–glucose co-transporter 2 inhibitor (SGLT2i) treatment may exert anti-inflammatory effects by modulating the NOD-like receptor family pyrin domain-containing 3 inflammasome and interleukin-17/23 inflammatory axis, which are both involved in the pathogenesis of psoriasis. However, the relationship between SGLT2i treatment and psoriasis remains unclear.

Aim
To investigate the association between SGLT2i treatment and incident psoriasis.

Methods
Using the Taiwan National Health Insurance Database for the period 2007–2018, we matched 103 745 patients with Type 2 diabetes mellitus (T2DM) receiving SGLT2i with a control group of patients with T2DM who did not use SGLT2i, matching them in a 1 : 2 ratio by age, sex, diabetes duration, insulin use and comorbidities, and evaluating the psoriasis risk in both groups.

Results
The incident psoriasis risk did not significantly differ between the SGLT2i and control groups [hazard ratio (HR) = 1.24, 95% CI 0.95–1.64] after adjustment for potential confounders. Insulin use (HR = 1.65, 95% CI 1.24–2.19) and chronic liver disease and cirrhosis (HR = 1.34, 95% CI 1.01–1.77) were significantly associated with increased psoriasis risk. A slightly increased psoriasis risk was also detected in certain SGLT2i user subgroups, especially those with renal disease (HR = 2.73, 95% CI 1.45–5.13).

Conclusion
SGLT2i-mediated protective effects in psoriasis could not be established. SGLT2i treatment increased psoriasis risk by 2.7-fold in patients with T2DM exhibiting renal diseases.
FiveQ: A new easy‐to‐use validated clinical instrument for tinnitus severity
Authors: Connell James , Harrison Ella , Bassiouni Ahmed , Sahota Raguwinder , Laden Stephanie , Carney Andrew Simon , Foreman Andrew , Krishnan Suren , O'Brien Sinead , Hodge John‐Charles 
Published: August 2022

AbstractObjectivesTinnitus is a complex and debilitating phenomenon with potentially significant implications on quality of life. New presentations can be resource and time intensive for clinicians. Validated comprehensive tinnitus questionnaires may lack practical utility in the high‐volume clinical setting. Concise, targeted questionnaires may offer an efficient alternative. This study aimed to assess the validity of the FiveQ, a novel five question construct designed to measure tinnitus severity. Convergent validity was assessed through correlating FiveQ against two comprehensive validated questionnaires, the Tinnitus Handicap Questionnaire (THQ) and Tinnitus Handicap Inventory (THI).DesignCross‐sectional study with prospective recruitment. The 117 voluntarily recruited participants completed the FiveQ, THI and THQ questionnaires. Results were comparatively analysed.SettingRecruitment was via electronic and print media, audiology clinics and public and private otolaryngology outpatient clinics. Surveys were completed electronically.ParticipantsMembers of the public aged over 18 with subjective tinnitus were invited to participate.Main Outcome MeasuredAnalyses for establishing the content validity, construct validity, internal consistency, explorary factor analysis, and responsiveness of FiveQ was performed.ResultsFiveQ demonstrated a high positive correlation with both the THI (r = 0.773, p < .001) and THQ (r = 0.808, p < .001). Internal consistency for FiveQ reached an acceptable threshold (Cronbach's alpha 0.86). Exploratory factor analysis demonstrated that one latent factor underlies the five items of the FiveQ. FiveQ demonstrated better responsiveness than both the THI and THQ after a 6 week interval repeat measurement.ConclusionFiveQ demonstrated high‐positive correlations with existing validated tinnitus questionnaires as well as acceptable internal consistency and factor analysis. The concise construct of FiveQ allows clinicians to efficiently estimate tinnitus severity, target treatment towards dominant symptoms and establish a reliable estimation of treatment response following interventions.