bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice
Authors: Hagihara Hideo , Shoji Hirotaka , Kuroiwa Mahomi , Graef Isabella A , Crabtree Gerald R , Nishi Akinori , Miyakawa Tsuyoshi 
Published: September 2022

Abstract
Calcineurin (Cn), a phosphatase important for synaptic plasticity and neuronal development, has been implicated in the etiology and pathophysiology of neuropsychiatric disorders, including schizophrenia, intellectual disability, autism spectrum disorders, epilepsy, and Alzheimer’s disease. Forebrain-specific conditional Cn knockout mice have been known to exhibit multiple behavioral phenotypes related to these disorders. In this study, we investigated whether Cn mutant mice show pseudo-immaturity of the dentate gyrus (iDG) in the hippocampus, which we have proposed as an endophenotype shared by these disorders. Expression of calbindin and GluR1, typical markers for mature DG granule cells (GCs), was decreased and that of doublecortin, calretinin, phospho-CREB, and dopamine D1 receptor (Drd1), markers for immature GC, was increased in Cn mutants. Phosphorylation of cAMP-dependent protein kinase (PKA) substrates (GluR1, ERK2, DARPP-32, PDE4) was increased and showed higher sensitivity to SKF81297, a Drd1 agonist, in Cn mutants than in controls. While cAMP/PKA signaling is increased in the iDG of Cn mutants, chronic treatment with rolipram, a selective PDE4 inhibitor that increases intracellular cAMP, ameliorated the iDG phenotype significantly and nesting behavior deficits with nominal significance. Chronic rolipram administration also decreased the phosphorylation of CREB, but not the other four PKA substrates examined, in Cn mutants. These results suggest that Cn deficiency induces pseudo-immaturity of GCs and that cAMP signaling increases to compensate for this maturation abnormality. This study further supports the idea that iDG is an endophenotype shared by certain neuropsychiatric disorders.
Multidetector computed tomography angiography study of the renal arterial vasculature anatomy and its variations in a Bulgarian adult population
Authors: Mihaylova Evgeniya , Groudeva Violeta , Nedevska Maria 
Published: September 2022

Abstract
Purpose: Renal arterial anatomy has a great clinical importance during surgical and endovascular procedures. However, comprehensive data on the renal arterial variations in the Bulgarian population has not yet been provided. The aim of this study was to conduct detailed research about the normal anatomy and variations of the renal arteries in the Bulgarian population.
Methods: Five hundred sixty one patients underwent contrast-enhanced multidetector computed tomography scans for the period 2016-2021. The images were retrospectively reviewed. Number, branching pattern, origin level and course of the renal arteries were noted. Data was categorized on the basis of laterality, gender and symmetry.
Results: Only 46.3% of the patients exhibited normal renal arterial anatomy. Variations were observed in 301 patients (53.7%). The most common variant was the presence of accessory renal arteries (ARA), discovered in 41.2% of the subjects. There was no significant difference based on gender and laterality (p>0.05). Hilar ARA (72.6%) were significantly more common than polar ARA (p<0.001). The most common origin location of main renal arteries and ARA was the aorta, followed by the common iliac arteries. Early division was observed in 21.7% of the patients, significantly more common on the right. Precaval course was found in 0.5% of the right main renal arteries and in 30% of ARA and the difference was significant (p<0.001).
Conclusion: These results show novel insight into the prevalence of renal arterial variations in Bulgarian population. Anatomic renal vasculature variants are common therefore awareness is crucial for the success of surgical and interventional procedures.
Knowledge and Risk Factors of Hepatitis B Disease Among Women Attending Antenatal Care at Arua Regional Referral Hospital, Arua, Uganda
Authors: Atwine Benjamin , Suleiman Mbaruk A. , Odongo Alfred Owino , Manenga Emmanuel 
Published: September 2022

Abstract
Background
Hepatitis B is a highly infectious disease with a prevalence of 4.3% among people aged 15–64 years, with a prevalence of 5.6% in men compared to 3.1% in women in Uganda. Mother-to-child transmission accounts for nearly 50% of new cases per year, and infants who acquire hepatitis B disease before 5 years have a 90% chance of progressing to chronic hepatitis B infection.
Objective
The study assessed the knowledge and risk factors of hepatitis B disease among women attending antenatal care (ANC) at Arua Regional Referral Hospital (ARRH), Uganda.
Methods
A cross-sectional study was carried out at ANC at ARRH. Convenience sampling was used, and a sample size of 384 was calculated. Each participant was evaluated using a structured questionnaire and screened for HBsAg using commercial rapid test kits. Assessment of knowledge was performed using a hepatitis B basic knowledge summary score. Data analysis was carried out using MICROSOFT EXCEL-2013 and STATA version 14 packages.
Results
Poor knowledge levels of hepatitis B disease stood at 17.9%, while 82.1% of the pregnant women had adequate knowledge. A prevalence of 2.05% was obtained from the participants in the study. None of the assessed risk factors was significantly associated with HBsAg positivity.
Conclusion
The study participants were knowledgeable to a great extent about hepatitis B disease, with 82.1% exhibiting good knowledge of hepatitis B disease. There are gaps in knowledge, especially among the low educated groups, which need to be addressed to improve knowledge levels of hepatitis B disease among these categories in the community. The results show a relatively healthy population given the low prevalence of 2.05% seen in the participants of the study. The absence of a risk factor associated with hepatitis B disease in this study does not imply that there are no risk factors in the community around ARRH. Further studies are recommended to assess more risk factors for hepatitis B disease in the community.
Post-operative recurrence of focal segmental glomerulosclerosis according to pre- transplant treatment after kidney transplantation
Authors: Kwon Hye Eun , Kim Young Hoon , Lee Sang Ah , Lee Jae Jun , Ko Youngmin , Shin Sung , Jung Joo Hee , Sung Frances S. , Baek Chung Hee , Kim Hyosang , Park Su-Kil , Kwon Hyunwook 
Published: September 2022

Abstract
Background
Recurrent focal segmental glomerulosclerosis (FSGS) after kidney transplantation (KT) is a serious complication and a significant risk factor for graft failure. However, there is no clear evidence of the effectiveness of pre-transplant treatment using plasmapheresis (PP) or rituximab in preventing post-operative FSGS recurrence after KT.
Methods
This single-center retrospective study included 99 adult patients with biopsy-proven primary FSGS who underwent KT between 2007 and 2018. The patients were divided into the pre-treatment group (N = 53, 53.5%) and no pre-treatment group (N = 46, 46.5%). In the pre-transplant group, prophylactic PP was administered before KT in patients undergoing living donor transplantation and the day after KT in those undergoing deceased donor transplantation.
Results
The rate of immediate post-operative recurrence was significantly higher in the no pre-treatment group (16 [34.8%]) than in the pre-treatment group (5 [9.4%]; P = 0.002). There were three cases of graft failure due to recurrent FSGS, all of which were in the no pre-treatment group. After adjusting for possible confounding factors, age (per 10-year increase; OR = 0.61, CI, 0.42–0.90; P = 0.012) and pre-transplant treatment (vs. no pre-transplant treatment; OR = 0.17, CI, 0.05–0.54; P = 0.003) were identified as significant factors associated with FSGS recurrence. The rate of death-censored graft survival was significantly superior in the pretransplant treatment group (P = 0.042).
Conclusions
Pre-transplant treatment with PP was associated with beneficial effects on preventing FSGS recurrence after KT.
Evaluation of systemic Inflammatory response markers in patients with preeclampsia
Authors: Husein Rama Ahmad Alsayed , Hamed Lina , Melhem Sara , Sakka Kanaan Al 
Published: September 2022

Abstract
Objective
The neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and mean platelet volume (MPV) are all indicators of systemic inflammatory response. The goal of this study was to assess changes in NLR, PLR, and MPV in preeclampsia (PE) and their use in predicting its severity.
Methods
This is a case-control study that was conducted in the past. The research included 140 healthy pregnant women as controls and 60 women with PE. These two groups were compared using demographic information as well as inflammatory indicators.
Results
There were no statistically significant variations in hemoglobin, gravida, parity, platelets, NLR, PLR, and MPV between healthy pregnant females and preeclamptic females (P > 0.05). In contrast, we discovered statistically significant differences in mean age, lymphocytes, and neutrophils between the control group and PE patients (P < 0.05).
Conclusion
Prospective multicenter studies are also required to determine the relationship between these indicators and PE.
Bone Mineral Density at Distal Forearm in Women in Mae Chaem District, Chiang Mai Province, Thailand: A Cross-Sectional Study
Authors: Thumvijit Tarika , Sriburee Sompong , Padngam Suratchanee , Tungjai Montree , Kothan Suchart 
Published: September 2022

Background:
Osteoporosis is a common health problem worldwide and has a high impact on quality of life and economic losses. However, having an early risk assessment can resolve the problem.

Objective:
To investigate the prevalence of bone mineral density (BMD) and osteoporosis in the distal forearm among Thai women in Mae Chaem District, Chiang Mai Province, Thailand.

Methods:
The subjects were 456 women, aged between 24-88 years who inhabit Mae Chaem District, Chiang Mai Province, Thailand. The demographic characteristics data was obtained by using self-administered questionnaires that determine common risk factors for osteoporosis. The BMD of the non-dominant distal forearm of all subjects was determined according to standard protocol by use of peripheral dual energy X-ray absorptiometry (pDEXA) scanning.

Results:
The BMD decreased as a function of age (Pearson's r = -0.645) while the BMD increased as a function of weight (Pearson's r = 0.389), and height (Pearson's r = 0.267). The percentage of prevalence is increased as a function of age-group in osteoporosis group, while it is decreased in that of normal bone density. In addition, the BMD at distal forearm decreased when the duration of menopause increased (Pearson's r = -0.455)

Conclusion:
The prevalence of osteoporosis was found in the women who reside in Mae Chaem District, Chiang Mai Province, Thailand. The current study will provide the information to guide the strategies for preventing osteoporosis in the population.
Credibility, Accuracy, and Comprehensiveness of Readily Available Internet-Based Information on Treatment and Management of Peripheral Artery Disease and Intermittent Claudication: Review
Authors: Alexander Shelley , Seenan Chris 
Published: September 2022

Background
Peripheral artery disease (PAD) affects millions of people worldwide, and a core component of management of the condition is self-management. The internet is an important source of health information for many people. However, the content of websites regarding treatment recommendations for PAD has not been fully evaluated.

Objective
This study aimed to assess the credibility, accuracy, and comprehensiveness of websites found via a common search engine, by comparing the content to current guidelines for treatment and management of PAD and intermittent claudication (IC).

Methods
A review of websites from hospitals, universities, governments, consumer organizations, and professional associations in the United States and the United Kingdom was conducted. Website recommendations for the treatment of PAD and IC were coded in accordance with the guidelines of the National Institute for Health and Care Excellence (NICE) and the American Heart Association (AHA). Primary outcomes were website credibility (4-item Journal of the American Medical Association benchmark), website accuracy (in terms of the percentage of accurate recommendations), and comprehensiveness of website recommendations (in terms of the percentage of guideline recommendations that were appropriately covered). Secondary outcomes were readability (Flesch–Kincaid grade level) and website quality (Health On the Net Foundation’s code of conduct).

Results
After screening, 62 websites were included in this analysis. Only 45% (28/62) of websites met the credibility requirement by stating they were updated after the NICE guidelines were published. Declaration of authorship and funding and the presence of reference lists were less commonly reported. Regarding accuracy, 81% (556/685) of website recommendations were deemed accurate on following NICE’s and the AHA’s recommendations. Comprehensiveness was low, with an average of 40% (25/62) of guideline treatment recommendations being appropriately covered by websites. In most cases, readability scores revealed that the websites were too complex for web-based consumer health information.

Conclusions
Web-based information from reputable sources about the treatment and management of PAD and IC are generally accurate but have low comprehensiveness, credibility, and readability.
Scottish Universities Open Access Press
Authors: Walker Dominique 
Published: September 2022

18 academic libraries across Scotland, through SCURL (Scottish Confederation of University and Research Libraries), are collaborating to develop a not-for-profit open access publishing platform that is owned and managed by the participating libraries. The aim of the Scottish Universities Open Access Press (SUOAP) is to provide a straightforward and cost-effective OA publication route for academics across Scottish HEIs, in response to changes in funder policies and Plan S. By publishing research open access, the SUOAP aims to raise the global visibility and usage of research at Scottish HEIs, increasing the high impact of Scottish HEI research outputs across all disciplines.
In this talk, Dominique Walker, the Publishing Officer for SUOAP, will set out the background to the project, discussing how SCURL’s experience of delivering cooperative developments for Scottish HEIs provided the foundation and the framework for creating a collaborative OA press. It will also look at where the development of the Press has reached so far, with the establishment of an online platform and formation of a diverse Editorial Board constituting academics from across the 18 institutions. It will also discuss the next steps, including plans to open a call for monograph proposals.
Overall the talk aims to show how Libraries and HEIs can work together to provide open access to research, providing alternative routes for publication and delivering a mutually beneficial outcome for the sector in Scotland.
As escolas multisseriadas do campo no Município de Cerro Azul: o processo de ensino e aprendizagem
Authors: Pianovsk Regina 
Published: September 2022

Resumo
Este artigo apresenta um recorte da tese de doutorado intitulada “Ensino e aprendizagem em escolas rurais multisseriadas e as contribuições da psicologia histórico-cultural e da pedagogia histórico-crítica”, desenvolvida durante o período de 2014 a 2017. Esta investigação teve como objetivo geral analisar o processo de ensino aprendizagem em sala de aula, em relação aos determinantes externos e internos que contribuem para concretizar a experiência das escolas multisseriadas. A metodologia da pesquisa de cunho qualitativo, desenvolveu-se mediante pesquisa bibliográfica e pesquisa de campo; sendo ancorada também pelos estudos desenvolvidos junto ao grupo de pesquisa do NUPECAMP[1] (Núcleo de Pesquisa em Educação do Campo, Movimentos Sociais e Práticas Pedagógicas), da Universidade Tuiuti do Paraná. Os resultados da pesquisa reforçaram o potencial inerente à essas escolas e a possibilidade do desenvolvimento de um ensino fundado numa concepção contra hegemônica de educação, que possibilite o acesso ao conhecimento científico, historicamente construído pela humanidade.
Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Microvascular Complications among Individuals with Type 2 Diabetes: A Prospective Study
Authors: Chen Xue , Wan Zhenzhen , Geng Tingting , Zhu Kai , Li Rui , Lu Qi , Lin Xiaoyu , Liu Sen , Chen Liangkai , Guo Yanjun , Shan Zhilei , Liu Liegang , Pan An , Manson JoAnn E. , Liu Gang 
Published: September 2022

<p> </p>
<p>Objectives: Evidence is limited regarding the associations between vitamin D status and microvascular complications in individuals with type 2 diabetes (T2D), among whom vitamin D deficiency or insufficiency is particularly common. This study aimed to prospectively investigate the associations of serum 25-hydroxyvitamin D [25(OH)D] and vitamin D receptor (VDR) polymorphisms with the risk of diabetic microvascular complications.</p>
<p>Research Design and Methods: This analysis included 14,709 participants with T2D who were free of microvascular complications from the UK Biobank. Incidence of diabetic microvascular complications were ascertained via electronic health records. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). </p>
<p>Results: The median (interquartile range) of serum 25(OH)D concentration was 40.7 (27.5, 56.4) nmol/L. During a median of 11.2 years of follow-up, 1,370 people developed diabetic microvascular complications. Compared with participants with 25(OH)D <25 nmol/L, individuals with 25(OH)D ≥75 nmol/L had a multivariable-adjusted HR (95% CI) of 0.65 (0.51, 0.84) for composite diabetic microvascular complications, 0.62 (0.40, 0.95) for diabetic retinopathy, 0.56 (0.40, 0.79) for diabetic nephropathy, and 0.48 (0.26, 0.89) for diabetic neuropathy. In addition, compared with participants with 25(OH)D <25 nmol/L and minor allele homozygotes (TT of rs1544410 and GG of rs731236), the multivariable-adjusted HRs (95% CIs) of composite diabetic microvascular complications were 0.54 (0.38, 0.78) and 0.55 (0.38, 0.80) for participants with serum 25(OH)D ≥50 nmol/L and major allele homozygotes (CC and AA), respectively, although no significant interaction was observed.</p>
<p>Conclusions: Higher serum 25(OH)D concentrations were significantly associated with lower risk of diabetic microvascular complications, including diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy. Our findings suggest a potential beneficial role of maintaining adequate vitamin D status in the prevention of diabetic microvascular complications.</p>
Sodium-Glucose Co-Transporter 2 inhibitors and the Short-term Risk of Bladder Cancer: An International Multi-Site Cohort Study
Authors: Abrahami Devin , Tesfaye Helen , Yin Huimin , Vine Seanna , Hicks Blanaid , Yu Oriana H.Y. , Campeau Lysanne , Platt Robert W. , Schneeweiss Sebastian , Patorno Elisabetta , Azoulay Laurent 
Published: September 2022

<p> </p>
<p><strong>Objective:</strong> To determine whether sodium-glucose co-transporter 2 (SGLT2) inhibitors, compared with glucagon-like peptide-receptor agonists (GLP-1RAs) or dipeptidyl peptidase-4 (DPP4) inhibitors are associated with an increased risk of early bladder cancer events.</p>
<p><strong>Research Design & Methods:</strong> We conducted a multi-site, population-based, new-user active comparator cohort study using the United Kingdom Clinical Practice Research Datalink, Medicare fee-for-service, Optum© Clinformatics® Data Mart, and MarketScan Health from January 2013 through December 2020. We assembled two cohorts of adults with type 2 diabetes initiating (1) SGLT2 inhibitors or GLP-1RAs, and (2) SGLT2 inhibitors or DPP4 inhibitors. Cox proportional hazards models were fit to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident bladder cancer. The models were weighted using propensity score fine stratification. Site-specific HRs were pooled using random-effects models.</p>
<p><strong>Results:</strong> SGLT2 inhibitor (n=453,560) and GLP-1RA (n=375,997) users had a median follow-up ranging from 1.5-2.2 years. Overall, SGLT2 inhibitors were not associated with an increased risk of bladder cancer, compared with GLP-1RAs (HR=0.90; 95% CI: 0.81-1.00). Similarly, when compared with DPP-4 inhibitors (n=853,186), SGLT2 inhibitors (n=347,059) were not associated with an increased risk of bladder cancer (HR: 0.99, 95% CI: 0.91-1.09) over a median follow-up ranging from 1.6-2.6 years. Results were consistent across sensitivity analyses.</p>
<p><strong>Conclusions: </strong>Contrary to previous randomized controlled trials, these findings indicate that the use of SGLT2 inhibitors is not associated with an increased risk of bladder cancer when compared with GLP-1RAs or DPP4 inhibitors. This should provide reassurance on the short-term effects of SGLT2 inhibitors on bladder cancer incidence.</p>
La gamificación como estrategia de evaluación bajo el enfoque flipped learning
Authors: Morales Salas Rubí Estela 
Published: September 2022

El flipped learning como metodología activa en la educación se ha convertido en una de las más usadas por los docentes de todo el mundo. Consiste en un enfoque integral de procesos y estrategias didácticas centradas en mejorar la experiencia de aprendizaje de los estudiantes y aumentar su compromiso e implicación en su propio proceso. Se presenta una experiencia educativa de un curso de estudiantes de posgrado desarrollada durante el primer semestre del 2021 cuyo objetivo fue identificar el nivel de satisfacción respecto a la implementación de la gamificación como estrategia de evaluación bajo el enfoque de flipped learning. Se sitúo como una investigación exploratoria, descriptiva-transversal, con un enfoque mixto y un muestreo no probabilístico por conveniencia. Se aplicó una encuesta mediante un cuestionario que consistió en una serie de preguntas. Los resultados muestran que la intervención fomentó la participación y proactividad de los estudiantes, por lo tanto, impulsó el aprendizaje y permitió aprovechar eficientemente el tiempo en el aula.
Oseanografi dalam Perspektif Al-Qur`an
Authors: Hasani Z Jufri 
Published: September 2022

Tulisan ini mencoba mengungkap mukjizat Al-Qur`an di bidang kelautan. Laut memiliki sumber daya alam yang melimpah, Allah telah menciptakan laut yang begitu luas, selain tempat berdiamnya ikan dan binatang laut lainnya, di laut juga tersimpan mutiara indah dan bernilai tinggi, energi laut yang sangat bermanfaat bagi manusia. Selain sumber kekayaan alam yang melimpah, di laut juga tersimpan energi yang bisa mendatangkan kerusakan bagi kehidupan manusia. Al-Qur`an memberikan informasi yang cukup kepada manusia tentang laut sehingga informasi-informasi Al-Qur`an tersebut menjadi dasar bagi manusia untuk mengembangkan ilmu dan teknologi kelautan sehingga ayat-ayat Al-Qur`an tentang laut semakin terungkap dan manfaat laut yang begitu banyak bisa diambil untuk kepentingan manusia. Penelitian ini menggunakan metode penelitian tafsir tematik sederhana di mana penulis mengumpulkan ayat-ayat tentang laut dan memilih beberapa ayat untuk ditafsirkan sesuai dengan tema dan sub pembahasan yang penulis susun sebelumnya. Ayat-ayat tersebut ditafsirkan dengan pendekatan sains dan teknologi untuk mendapatkan informasi secukupnya tentang pesan-pesan Al-Qur`an terkait laut.