bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Recurrent Pancreatitis in a Child With INS-Related Monogenic Diabetes and a Heterozygous Pathogenic CFTR Mutation
Authors: Son Rachel G , Kandasamy Balamurugan , Bowden Tiana , Azzam Ruba K , Oakes Scott A , Philipson Louis H , Greeley Siri Atma W 
Published: December 2022

Abstract
Given the close anatomical and physiological links between the exocrine and endocrine pancreas, diseases of 1 compartment often affect the other through mechanisms that remain poorly understood. Pancreatitis has been associated with both type 1 and type 2 diabetes, but its association with monogenic diabetes is unknown. Patients heterozygous for pathogenic CFTR variants are cystic fibrosis carriers and have been reported to have an increased risk of acute pancreatitis. We describe a 12-year-old patient with monogenic neonatal diabetes due to a pathogenic heterozygous paternally inherited mutation of the insulin gene (INS), c.94 G &gt; A (p.Gly32Ser), who experienced 3 recurrent episodes of acute pancreatitis over 7 months in conjunction with poor glycemic control, despite extensive efforts to improve glycemic control in the past 4 years. Intriguingly, the maternal side of the family has an extensive history of adult-onset pancreatitis consistent with autosomal dominant inheritance and the proband is heterozygous for a maternally inherited, CFTR variant c.3909C &gt; G (p.Asn1303Lys). Paternally inherited monogenic neonatal diabetes may have promoted earlier age-of-onset of pancreatitis in this pediatric patient compared to maternal relatives with adult-onset acute pancreatitis. Further study is needed to clarify how separate pathophysiologies associated with INS and CFTR mutations influence interactions between the endocrine and exocrine pancreas.
Louis Pasteur continues to shape the future of microbiology
Authors: Mostowy Serge 
Published: December 2022

ABSTRACT
Louis Pasteur made seminal discoveries in microbiology, immunology and vaccinology that transformed clinical science and saved millions of lives. Since the 19th century, our ability to study infectious disease has undergone radical changes due to newly emerging technologies and infection models. In this Editorial, I consider Pasteur's impact on our ability to understand and combat infectious disease in the context of two modern-day pandemics: coronavirus disease 2019 (COVID-19) and antimicrobial resistance (AMR). During the COVID-19 pandemic, we witnessed remarkable ambition to understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and to innovate effective vaccines to prevent disease. For the comparatively overlooked pandemic of AMR, we require the same level of urgency to develop alternative approaches to combat antibiotic-resistant bacterial strains that cause millions of deaths annually. Pasteur's statement “chance only favours the mind which is prepared” is a principle that captures ‘l'esprit Pasteur’. This principle should continue to guide modern-day research on infectious disease, and for this we need to support the development of predictive disease models and cutting-edge mechanistic research that prepare us for discovery and therapeutic impact.
Neural crest cell-placodal neuron interactions are mediated by Cadherin-7 and N-cadherin during early chick trigeminal ganglion assembly
Authors: Halmi Caroline A. , Wu Chyong-Yi , Taneyhill Lisa A. 
Published: December 2022

Background: Arising at distinct positions in the head, the cranial ganglia are crucial for integrating various sensory inputs. The largest of these ganglia is the trigeminal ganglion, which relays pain, touch and temperature information through its three primary nerve branches to the central nervous system. The trigeminal ganglion and its nerves are composed of derivatives of two critical embryonic cell types, neural crest cells and placode cells, that migrate from different anatomical locations, coalesce together, and differentiate to form trigeminal sensory neurons and supporting glia. While the dual cellular origin of the trigeminal ganglion has been known for over 60 years, molecules expressed by neural crest cells and placode cells that regulate initial ganglion assembly remain obscure. Prior studies revealed the importance of cell surface cadherin proteins during early trigeminal gangliogenesis, with Cadherin-7 and neural cadherin (N-cadherin) expressed in neural crest cells and placode cells, respectively. Although cadherins typically interact in a homophilic (i.e., like) fashion, the presence of different cadherins expressed in neural crest cells and placode cells raises the question as to whether heterophilic cadherin interactions may also be occurring. Given this, the aim of the study was to understand whether Cadherin-7 and N-cadherin were interacting during initial trigeminal ganglion formation. Methods: To assess potential interactions between Cadherin-7 and N-cadherin, we used biochemistry and innovative imaging assays conducted in vitro and in vivo, including in the forming chick trigeminal ganglion. Results: Our data revealed a physical interaction between Cadherin-7 and N-cadherin. Conclusions: These studies identify a new molecular basis by which neural crest cells and placode cells can aggregate in vivo to build the trigeminal ganglion during embryogenesis.
Case Report: Wellens syndrome in acute total occlusion saved by collateral
Authors: Alsagaff Mochamad Yusuf , Putra Tony Santoso , Khrisna Bagus Putra Dharma , Nugraha Ricardo Adrian 
Published: December 2022

Background: It is important and challenging to distinguish between acute myocardial infarction and Wellens syndrome due to its time to intervention. Difficulties in differentiating between subtypes could mean the patients are overtreated or receive undertreatment. Case report: A 57-year-old man was referred to our emergency ward with acute onset of chest pain. Electrocardiographic (ECG) changes were suggestive of Wellens syndrome type A. Nitroglycerin was administrated, the patient's chest pain disappeared, and we planned an early invasive strategy. He had a previous documented ECG before he went for catheterization and based on the second ECG changes were suggestive of an ST elevation. As the result of the invasive strategy, it was found that there was single-vessel disease, near total occlusion in the middle of the left anterior descending artery (LAD) with collateral from the right coronary artery. After two days of observation in the Intensive Cardiovascular Care Unit (ICCU), the patient improved and was transferred to the Low Care Unit. Conclusions: The case highlights Wellens syndrome in acute total occlusion with collateral artery.
Importance of social support for Indonesian stroke patients with depression
Authors: Yamanie Nizar , Lamuri Aly , Felistia Yuli , Soedirham Oedojo , Purnomo Windhu , Sjaaf Amal Chalik , Miftahussurur Muhammad 
Published: December 2022

Background: Approximately one-third of stroke survivors experience depression at some point, which is linked to poor functional results and high mortality rate. Social support from family, friends, and the community is an intervening variable in stroke outcomes aside from the rehabilitation treatments that patients receive. This study assessed the importance of social support for stroke patients with depression and its relationship with patient rehabilitation. Methods: This quantitative study used a cross-sectional approach on stroke patients and their families based on data from the Social Security Administrator for Health (BPJS Kesehatan). One hundred and four participants were recruited using purposive sampling by including stroke patients who have used National Health Insurance (JKN) for stroke medications. Results: We found that instrumental, emotional, interactive, and information support contribute to lowering depressive symptoms. Instrumental support in the form of food availability, money, goods, and services had the highest coefficient value for reducing depression. Emotional support in the form of care and compassion had the second highest value in reducing depression. Further, interaction and informational support remain critical components of social support in reducing depression. Conclusion: The support system plays a key role in decreasing the depression level in stroke survivors. The family and neighborhood have a significant impact on accelerating the rehabilitation process of stroke patients by providing support.
KEY PERFORMANCE INDICATORS OF INDUSTRIAL SAFETY OF ENTERPRISES
Authors: Demareva Elena E. 
Published: December 2022

This article discusses the issues of assessing the level of industrial safety of enterprises in terms of the efficiency of industrial enterprises, requiring an increase in production efficiency, ensuring the efficiency of products and services by mastering the ways of effective production management, the achievements of scientific and technological progress.
Purpose: The article discusses key performance indicators as methods of industrial safety of an enterprise and a tool for analyzing and evaluating the level of a company’s performance.
Method, methodology of the work: The article used theoretical materials, economic and mathematical methods, statistical methods of analysis.
Results: The most informative parameters were obtained, showing some aspects of the analysis of key performance indicators of industrial enterprises.
Scope of the results: The results obtained can be successfully applied in different areas of the economy for different economic entities, it is possible to use both for young firms and for organizations with sufficient experience.
DEVELOPING THE STRUCTURE OF A WEB APPLICATION FOR PERSONAL FINANCE ACCOUNTING
Authors: Pavlova Anna I. , Kuskov Nikita S. 
Published: December 2022

Modern payment services in the form of online banks and accounting services are designed to monitor the user’s funds. This allows you to track bank transactions through a personal account of the web-application, to keep track of the receipt or expenditure of funds. However, for a user who has several credit cards, current accounts, deposits in banks it is necessary to integrate information about current funds in a single information space.
The purpose of the study is to develop a prototype web application for accounting personal finances.
Method or methodology of work: methods of designing information systems.
Results: the analysis of financial accounting applications has shown that they have a number of similar functionalities. These features are related to the registration of the user, the cardholder of a particular bank, tracking the progress of transactions, and ensuring security. However, the applications are limited in terms of the ability to record personal finances of third-party bank cards or electronic virtual accounts (e.g., mobile operators). Therefore, in our work we have developed an application architect, consisting of seven pages. The main page of the site is needed to ensure the safety of the application, receiving notifications from the banks by the user. The main functional purpose of the pages of the site - cards, credits, payments and transfers is aimed at interactive interaction of user with different banks, providing control of receipt and expenditure of money kept on different accounts. It is suggested to introduce the pages goals and calendar into the structure of the site to enable the user to plan expenses by specifying the list of goods and services at certain periods of time. The site page “settings” is used for tweaking the styles of the web-application.
Scope of the results: the developed prototype of web-application for accounting of personal finances is needed for practical implementation of the application, which will allow integrating information about the current state of the user’s money.
Experimental demonstration of real-time optical DFT-S DMT signal transmission for a blue-LED-based UWOC system using spatial diversity reception
Authors: Chen Ruilin , Du Ji , Wang Yuan , Fei Chao , Zhang Tianyi , Tian Jiahan , Zhang Guowu , Hong Xiaojian , He Sailing 
Published: December 2022

Underwater wireless optical communication (UWOC) has broad prospects in underwater real-time applications. We design and experimentally demonstrate a real-time discrete Fourier transform spread discrete multi-tone (DFT-S DMT) signal transmission based on a field programmable gate array for a blue-LED-based UWOC system with a data rate of up to 30 Mbps over a 15-m underwater channel. The architecture and usage of an on-chip resource as well as power consumption are analyzed and discussed. To reduce the impacts of multipath fading and received intensity fluctuation, spatial diversity reception is also introduced. Furthermore, the receiver sensitivity at a specified bit error rate (BER) threshold and the quality of the images are evaluated using three types of Reed–Solomon (RS) codes. At the BER threshold of

10

−
4

, over 2.8-dB receiver sensitivity improvement is obtained by the DFT-S DMT scheme with the RS (64, 56) code as compared to the uncoded one at the data rate of 30 Mbps. The performance of BER, color difference, and structural similarity in the image transmission of DFT-S DMT is superior to that of the conventional hard clipping quadrature amplitude modulation DMT in a high-data-rate region because of the low peak-to-average-power ratio and ability to mitigate high-frequency fading in a band-limited UWOC system. With schemes of the RS code, DFT-S, and diversity reception, error-free transmission of images is achieved over a 15-m water channel. The proposed UWOC system has the advantages of low power consumption and portability, which foresees a bright future in underwater applications over short to moderate distances.
Optimierung der Prozesse im Retoureneingang: E-Commerce Case Study für den B2C-Bereich
Authors: Stevenson Anthony Boyd , Rieck Julia 
Published: December 2022

ZusammenfassungDie Anzahl der Bestellungen im B2C-E-Commerce nimmt stetig zu und so auch die Anzahl der Retouren (vgl. Asdecker et al. 2021, S. 606). Bei einigen Online-Shops wurde dieses Wachstum durch die Corona-Pandemie begünstigt, was dazu führte, dass die logistischen Prozesse dem starken Anstieg der Bestellungen und Retouren nicht mehr gewachsen sind. Vor allem kleine Unternehmen mit nicht-digitalisierten Prozessen haben Schwierigkeiten, sich diesen Herausforderungen zu stellen und effizient und wirtschaftlich zu arbeiten. In einer Case Study wird das Retourenlager eines kooperierenden B2C-Onlineshops für Möbel und Wohnaccessoires analysiert und im Hinblick auf den Prozess des Retoureneingangs und der -bearbeitung optimiert. In einem ersten Schritt werden mittels Frequent Itemset Mining häufig auftretende Retouren-Charakteristika identifiziert. Aufgrund der gewonnenen Erkenntnisse werden Klassen gebildet, in die eintreffende Retouren eingeordnet werden. Die Lagermitarbeitenden werden bei dieser Vorsortierung durch einen implementierten Prototyp unterstützt, der eingehende Retouren anhand der Daten aus dem ERP-System gezielt sortiert. Durch die entsprechende Abarbeitung der Retouren ergibt sich eine deutliche Verbesserung der Prozesse gegenüber der aktuell umgesetzten FIFO-Abarbeitung.
“Like a pickle that’s been unpickled”: Emotional, identity and behavioural transformations throughout hepatitis C treatment
Authors: Goutzamanis Stelliana , Doyle Joseph S. , Horyniak Danielle , Higgs Peter , Hellard Margaret 
Published: December 2022

BackgroundLittle is known about the emotional experience and benefits of undertaking direct acting antiviral (DAA) treatment for hepatitis C. A better understanding of individual treatment outcomes can inform acceptable treatment delivery and promotion. We aimed to explore participant-perceived emotional benefits and transformations throughout DAA treatment among people who inject drugs, who were initiating treatment.MethodsParticipants were recruited from either a community based clinical trial or community health clinics. Semi structured interviews were conducted with each participant before, during and following treatment. Interviews focussed on treatment perceptions, physical and mental wellbeing and modifiable health behaviours. Interviews were recorded, transcribed verbatim and thematically analysed. Participant and cohort matrices were produced to assess at which time point themes were present and whether themes changed or remained stable over time.ResultsThis paper presents analysis from 19 participants interviewed between 2017–2019. Most participants were male, with no or mild fibrosis. At baseline, all but one participant had injected drugs in the past month. Three themes relating to the emotional wellbeing and behaviour change described a common treatment experience; ‘hopes for better wellbeing’, ‘lifting the weight’ and ‘closing the chapter’. Participants were hopeful treatment would improve their emotional wellbeing. Hopes were actualised during treatment as participants began to feel uncertainty and stress easing. Completing treatment improved some participants perceptions of self. Some participants consciously changed their injecting behaviours during treatment.ConclusionUndertaking and completing treatment was an emotionally and behaviourally transformative period. Participant perceived benefits should be used to inform how treatment benefit is conceptualised and how treatment is promoted in primary care settings.
THE COMMON HERITAGE OF MANKIND AND THE WORLD HERITAGE: CORRELATION OF CONCEPTS
Authors: Anisimov Igor Olegovich , Gulyaeva Elena Evgenyevna 
Published: December 2022

Contextualizacíon: The issues of legal regulation of the concepts of common heritage of mankind and world cultural and natural heritage have been actively discussed in science and have been the object of close attention in practice for more than a decade, but by now the context of their consideration has noticeably changed.
Objectives: This study focuses on the history of the emergence and development of the concept of the common heritage of mankind and the concept of world heritage. Particular attention is paid to the international legal regulation of both concepts and the analysis of their content. The article reveals the criteria and conditions for the universal value of the world heritage, gives a definition of the concepts of «common heritage of mankind» and «world cultural and natural heritage».
Methodology: The research uses the inductive method and literature review.
Result: It is concluded that the conclusion that any modifications and expansion of the scope of the concept of the common heritage of mankind can affect the approach to the concept of state sovereignty, thereby affecting the stability of the international legal order.
A SOJA TRANSFORMANDO CHAPADÃO DO SUL
Authors: Rocha Jonas Romão da , Pessôa Vera Lúcia Salazar 
Published: December 2022

O objetivo desse trabalho é mostrar a influência da soja no processo de modernização e
desenvolvimento da agricultura no município de Chapadão do Sul-MS, a partir da década de
1980. Para melhor entendermos o referido processo de modernização, fez-se necessário um
breve relato de como ocorreu o processo de modernização agrícola no Brasil, mostrando seus
efeitos nos modos de produção agrícola, alterando a economia do país e o modo de vida da
população rural, devido a chegada de novas tecnologias provenientes do processo industrial.
A partir daí mostramos o avanço da agricultura para a região Centro-Oeste e posteriormente
o desenvolvimento da agricultura no município de Chapadão do Sul-MS.
FORMOSA: PORTAL DO NORDESTE GOIANO OU UM PÓLO REGIONAL NO ENTORNO DE BRASÍLIA?
Authors: Teixeira Renato Araújo , Barreira Celene Cunha Monteiro Antunes 
Published: December 2022

O artigo que se apresenta, sob o título "Formosa - Portal do Nordeste goiano ou um pólo
regional do Entorno de Brasília, coloca em questão duas unidades temáticas: o município e a
região. Estes, interligados, assumem a proposta metodológica desenvolvida por Barreira que
estuda a Geografia do município, em que delineia-se os seus aspectos históricos, econômicos,
culturais, enfim, um esboço da geografia goiana. Essa dinâmica de análise regional
proporciona, dentre outras estratégias de pesquisa, uma produção geográfica importante
dentro do cenário goiano e também nacional. O presente trabalho tem como objetivo geral
analisar a evolução sócio-espacial do município de Formosa a partir da relação com a Capital
Federal - Brasília. De maneira específica, caracterizaremos os reflexos espaciais na atualidade
do Distrito Federal para o município de Formosa. Dentro dessa problemática, verificaremos,
também, a importância sócio-econômica do município de Formosa em relação à microrregião
do Entorno de Brasília e Nordeste Goiano. Essa pesquisa considera a diversidade regional
do Entorno de Brasília como síntese histórica do espaço, produto e meio de toda a vida social.
Os resultados nos direcionam no entendimento das formas de penetração do capital no
município de Formosa, percebemos que esse município é visto como portal do Nordeste Goiano,
sendo uma economia funcional ao Distrito Federal, configurando-se como um pólo regional
em formação.
VIOLÊNCIA URBANA EM UBERLÂNDIA/MG: UMA ANÁLISE SÓCIOESPACIAL DOS HOMICÍDIOS
Authors: Santos Márcia Andréia Ferreira , Ramires Julio Cesar de Lima 
Published: December 2022

Este artigo tem como objetivo analisar a violência urbana em Uberlândia, destacando a
ocorrência dos homicídios no espaço da cidade. O período de análise concentrou-se entre
2000 e 2003. Foram utilizados dados sobre homicídios do Núcleo de Informação em Saúde,
Centro de Operações da Polícia Militar e Ministério da Saúde. Verificou-se que os homicídios
na cidade seguem o mesmo padrão constatado por outros autores em pesquisas realizadas em
grandes cidades do país.
KEHUJAHAN HUKUM NEGARA SEBAGAI SUMBER HUKUM ISLAM: STUDI KOMPARASI PEMIKIRAN SAYYID MUHAMMAD RASYID RIDA DAN WAHBAH AZ-ZUHAILI
Authors: Yaqin Nasrullah Ainul 
Published: December 2022

Kajian terhadap kehujahan hukum Negara sebagai sumber hukum Islam dalam dirkursus usûl al-fiqh adalah masih sangat jarang dilakukan oleh para ulama usû} l al-fiqh, khususnya ketika membahas sumber-sumber hukum Islam; kecuali apa yang dilakukan oleh Wahbah az-Zuha}ilî dalam kitab usû}l al-fiqhnya (al-Fiqh al-Islâmî), di mana dia menjelaskan secara utuh dan komprehensif bahwa hukum Negara tidaklah bisa dijadikan sebagai sumber hukum Islam karena dihasilkan dari akal secara an sich. Di sisi lain, jauh sebelum itu, Sayyid Muhammad Rasyîd Ridâ} telah membahas secara detail mengenai kehujahan hukum Negara sebagai sumber hukum Islam dalam kitab tafsirnya (al-Manâr). Dia menerima secara mutlak kehujahan hukum Negara sebagai sumber hukum Islam asal hukum tersebut mengandung nilai keadilan. Tidak lain karena hukum Allah adalah keadilan itu sendiri, sebagaimana banyak dijelaskan dalam Al-Qur’an. Adapun menurut Wahbah az-Zuha} ilî hukum Negara tidak bisa dijadikan sebagai sumber hukum Islam karena dihasilkan dari akal semata, di mana para ulama telah sepakat bahwa akal murni tidak dapat dijadikan sebagai sumber hukum Islam. Oleh karenanya, hukum Negara bisa dijadikan sumber hukum Islam adalah apabila hukum tersebut disandarkan kepada wahyu Ilahi, baik langsung (Al-Qur’an dan Hadis) maupun tidak (kaidah- kaidah umum dan spirit syariat Islam). Selain itu, meski pun terjadi perbedaan pandangan, namun terdapat titik-temu di antara pemikiran keduanya, yaitu sama-sama menerima akan kehujahan hukum Negara sebagai sumber hukum Islam. Sayyid Muha} mmad Rasyîd Ridâ} menerima hukum Negara sebagai sumber hukum Islam asal hukum tersebut mengandung keadilan, sementara Wahbah az-Zuha} ilî menerimanya asal hukum tersebut disandarkan kepada wahyu Ilahi, baik langsung maupun tidak.