bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengolahan Jamu Tradisional sebagai Minuman Peningkat Imunitas Tubuh
Authors: Tito Sama’ Iradat , Ma’ruf Muhammad , Roikhana Arina , Maghfirah Lailatul , Setiawati Sulis , Chumairoh Zuhrotul , Mufida Nur , Hasanah Durrotul 
Published: March 2022

Jamu merupakan obat tradisonal dengan bahan dasarnya berasal dari alam dengan pemberian dari warisan budaya secara turun-temurun dari generasi ke generasi. Dimasa pandemi Covid-19 ini, masyarakat disarankan untuk banyak mengonsumsi jamu dengan tujuan untuk meningkatkan imunitas tubuh selama pandemi ini. Salah satu upaya yang dapat dilakukan yakni melakukan sosialisasi kepada Ibu PKK serta perangkat Desa Srimulyo tentang pengolahan jamu tradisonal yang mempunyai potensi sebagai minuman peningkat imunitas tubuh. Metode yang digunakan yaitu metode pendekatan langsung, cerama dan praktek. Metode pendekatan yang dilakukan untuk mengetahui permasalahan yang ada di Desa Srimulyo. Metode ceramah dilakukan memberikan informasi tentang manfaat dari jamu tradisional sebagai minuman meningkatkan imunitas tubuh. Metode praktek dilakukan untuk memberikan pelatihan pengolahan jamu tradisional yang baik dan benar. Hasil yang didapat melalui kuisioner uji organoleptik didapat nilai rata-rata rasa olahan jamu tradisional 3.60, nilai rata-rata aroma olahan jamu tradisional 3.85, nilai rata-rata warna olahan jamu tradisional 3.75, dan nilai rata-rata kesukaan olahan jamu tradisional 3.70.
MENEJEMEN SARANA PRASARANA DALAM MENINGKATKAN MUTU LULUSAN DI MTs NEGERI TRIWARNO KUTOWINANGUN KEBUMEN
Authors: Safingudin Ahmad 
Published: March 2022

Sarana prasarana merupakan faktor penting dalam meningkatkan mutu lulusan, Madrasah Tsanawiyah Negeri Triwarno Kutowinangun Kebumen dalam dua tahun terakhir ini sangat konsen terhadap pemenuhan sarana dan prasarana, penelitian ini bertujuan untuk: (1) Mengkaji dan membahas Perencanaan Menejemen Sarana dan Prasarana Pendidikan dalam Meningkatkan Mutu Lulusan di MTs Negeri Triwarno Kutowinangun Kebumen, (2) Menganalisi Pengorganisasian Manajemen Sarana dan Prasarana Pendidikan dalam Meningkatkan Mutu Lulusan di MTs Negeri Triwarno Kutowinangun Kebumen. (3). Menganalisis dan Membahas Pengarahan Manajemen Sarana dan Prasarana Pendidikan dalam Meningkatkan Mutu Lulusan di MTs Negeri Triwarno Kutowinangun Kebumen. (4). Menganalisis Pengendalian Manajemen Sarana dan Prasarana Pendidikan dalam Meningkatkan Mutu Lulusan di MTs Negeri Triwarno Kutowinangun Kebumen.
Penelitian ini menggunakan metode kualitatif. Penelitian dilakukan di MTs Negeri Triwarno Kutowinangun Kebumen, pada bulan Mei sampai Oktober 2017. Subjek dalam penelitian ini adalah Kepala Madrasah dan Waka Sarana Prasarana MTs Negeri Triwarno Kutowinangun Kebumen. Adapun informan dalam penelitian adalah Guru dan Siswa. Teknik pengumpulan data dengan cara wawancara, observasi dan dokumentasi. Teknik keabsahan data menggunakan Triangulasi data dan Triangulasi sumber. Teknik analisis data menggunakan metode interaktif, pengumpulan data, penyajian data, reduksi data dan penarikan kesimpulan.
Hasil penelitian diketahui bahwa Menejemen sarana dan prasarana dalam peningkatan mutu lulusan di MTs Negeri Triwarno Kutowinangun Kebumen dilakukan dengan (1) Perencanaan Sarana dan Prasarana (Planing), yaitu rapat koordinasi madrasah, penetapan program madrasah, serta penetapan kebutuhan sarana dan prasarana pendidikan. (2) Pengorganisasian Sarana dan Prasarana (Organizing) meliputi pengaturan struktur organisasi pengelola sarana dan prasarana, pembagian tugas kerja/job deskripsi, pengaturan alat dan bahan praktek, serta pengaturan kegiatan praktek. (3) Pengarahan Sarana dan Prasarana (Actuating) berupa pengadaan, pemeliharaan dan penghapusan sarana dan prasarana. (4) Pengontrolan Sarana dan Prasarana (Controling) dilakukan dengan inventarisasi. Penggunaan sarana dan prasarana hendaknya disesuaikan dengan kebutuhan agar diperoleh manfaat dari penggunaan tersebut. Seluruh warga madrasah hendaknya memanfaatkan sarana dan prasarana yang dimiliki madrasah agar tidak terbuang percuma hanya menjadi hiasan saja karena pada dasarnya semua fasilitas madrasah diadakan untuk memberikan layanan yang terbaik kepada semua warga madrasah. Pemeliharaan sarana dan prasarana madrasah tidak hanya diserahkan pada petugas yang menanganinya saja tetapi sumbangsih atau proaktif semua warga madrasah juga diperlukan agar semua program yang direncanakan dalam pemeliharaan madrasah dapat terealisasikan dengan baik demi kelangsungan proses pendidikan di madrasah.
Kata kunci: Manajemen, Sarana Prasarana, Mutu Lulusan
KEPEMIMPINAN KEPALA SEKOLAH DALAM MENINGKATKAN PROFESIONALISME GURU DI SMP NEGERI 40 PURWOREJO
Authors: Zulaikah Siti 
Published: March 2022

Penelitian ini didasari oleh kepemimpinan kepala sekolah yang cukup baik. Sehubungan dengan hal itu, penelitian ini bertujuan untuk mengetahui kepemimpinan kepala sekolah dalam meningkatkan profesionalisme guru di SMP Negeri 40 Purworejo. Penelitian ini menggunakan penelitian kualitatif yang menitik beratkan pada gejala secara alamiah dan dianalisis dengan menggunakan logika berpikir ilmiah. Adapun teknik pengumpulan data pada penelitian ini diperoleh melalui observasi, wawancara, dokumentasi, dan triangulasi. Analisis data dilakukan dengan reduksi data, penyajian data, dan verifikasi data kemudian merumuskan kesimpulan hasil penelitian yang dilakukan. Ada tiga hal yang dikemukakan dalam penelitian ini, yaitu: (1) kemampuan manajerial kepala sekolah kaitannya dengan chief officer dalam meningkatkan profesionalisme guru di SMP Negeri 40 Purworejo terbukti nyata menghasilkan produk visi dan misi sekolah yang telah dilaksanakan dengan baik meskipun masih belum semuanya, dan untuk mencapainya dibutuhkan kerja sama yang baik dengan semua elemen sekolah; peran dari kepala sekolah untuk menciptakan suasana yang harmonis di lingkungan sekolah, dengan memberikan tugas guru sesuai tupoksinya dan guru dapat menjalankan tugas dan tanggungjawabnya dengan profesional; memberi kesempatan kepada tenaga pendidik untuk meningkatkan profesinya; (2) kemampuan Sense of business Kepala Sekolah dalam meningkatkan profesionalisme guru, dibuktikan dengan kemampuan kepala sekolah dalam mengelola dana pendidikan terutama dalam mencari sumber dana pendidikan untuk mencukupi kebutuhan dalam penyelenggaraan pendidikan; (3) kemampuan sense of education kepala sekolah dalam meningkatkan profesionalisme guru, yang di buktikan dengan kemampuan kepala sekolah dalam melakukan pembinaan mental, pembinaan moral, pembinaan fisik dan pembinaan artistik yang di laksanakan secara terprogram.
Platelet-Activating Biominerals Enhanced Injectable Hydrogels With Superior Bioactivity for Bone Regeneration
Authors: Chen Xin , Yan Jiajun , Jiang Yingying , Fan Yunshan , Ying Zhengran , Tan Shuo , Zhou Zhi , Liu Junjian , Chen Feng , He Shisheng 
Published: March 2022

Refractory bone fracture, which is difficult to be treated, is a common clinical disease. Taking inspiration from the natural process of bone regeneration, we provide a biomimetic strategy to develop a new injectable biomaterial for repairing bone defects, which is mainly composed of platelets, fibrins, and biominerals. Biomineral nanoparticles (EACPNs) with an amorphous phase are prepared by an enzyme-catalyzed route and display a platelet-activating property. The composite hydrogel (EPH) of EACPNs, fibrins, and platelets is injectable, and has similar chemical properties to natural materials in bone regeneration. The dried EPH samples display a highly porous structure, which would be favorable for cell attachment and growth. The results from in vitro studies indicate that EPH has high biocompatibility and superior bioactivity in promoting the osteogenic differentiation of rat bone marrow stem cells (rBMSCs). Furthermore, the results from in vivo studies clearly indicate that EPH can induce the formation of new collagen and vessels in the defect area, thus leading to faster regeneration of bone defects at 2 weeks. Our study provides a strategy for designing new biomimetic materials, which may be favorable in the treatment of refractory bone fracture.
Successful Management of Mixed Mycosis in HIV-Negative Patients With Different Immune Status: A Case Series Report
Authors: Zhan Yangqing , Lu Chun , Li Shaoqiang , Zhao Jin , Li Zhengtu , Gu Yingying , Ye Feng 
Published: March 2022

ObjectiveThe limited information available on mixed mycosis involving the lungs makes the understanding of mixed fungal diseases insufficient and affects prognosis. Our study aims to improve understanding by exploring experience in the successful management of mixed fungal infections.MethodsPatients who had two types of mycosis involving the lung at the same disease course were retrospectively enrolled.ResultsBetween September 2011 and December 2019, 17 patients with proven mixed mycosis were enrolled. Four patients were immunocompromised, with one case each of lung transplantation, corticosteroid treatment, STAT3 hyper-IgE syndrome, and anti-IFN-γ autoantibody-associated immunodeficiency syndrome. Among 13 patients who were not immunocompromised, 9 had type 2 diabetes mellitus. Eight cases were coinfection with Mucor and Aspergillus, 4 cases were Cryptococcus and Aspergillus, 2 cases were Talaromyces marneffei and Cryptococcus, 2 cases were Talaromyces marneffei and Aspergillus, and 1 case was Candida and Aspergillus. Seven patients were diagnosed with mixed pulmonary mycosis at almost the same time. Among the remaining 10 patients, the initial treatment was ineffective in four cases, and six patients showed a partial response to the initial antifungal treatment, but the original fungal lesions became re-enlarged. Three patients were admitted to the intensive care unit during hospitalization, and one patient died. Another Mucor coinfection patient died due to treatment refusal.ConclusionMixed mycosis involving the lungs is not uncommon in patients without apparent immune deficiency diseases. During the management of mycosis, we recommend keeping mixed mycosis in mind for patients with a poor response to initial antifungal treatment, even in immunocompetent populations, and identifying the cause of illness through a rigorous procedure.
Elevated Plasma Thymic Stromal Lymphopoietin After Acute Myocardial Infarction
Authors: Zhao Yuhao , Zhang Yeping , Guo Zongsheng , Ma Zheng , Liu Ye , Han Chunming , Yang Xinchun , Zhao Lei 
Published: March 2022

BackgroundThymic stromal lymphopoietin (TSLP), a distant paralog of the cytokine IL-7, has been shown to be associated with atherosclerosis. However, the effect of plasma TSLP level after acute myocardial infarction (AMI) remains largely unclear. Thus, we aimed to assess the relationship between the concentration of TSLP at admission and the risk of major adverse cardiovascular events (MACE) in AMI patients.MethodsA total of 175 patients with AMI and 145 unstable angina (UA) controls were recruited in the present study. The clinical characteristics were collected, and MACE was recorded during hospitalization and the follow-up period after discharge.ResultsThe median value (25, 75 percentiles) of TSLP concentrations in the AMI group was higher than that in the UA group [11.18 (8.14–15.22) vs. 8.56 (5.26–11.94) pg/ml, p &lt; 0.001, respectively]. Multivariate linear regression analysis revealed that Troponin-I (standardized β = 0.183, p = 0.004) was an independent factor for TSLP. According to the median of TSLP concentrations, all the AMI patients were divided into the high-level group (TSLP level ≥ 11.18 pg/ml, N = 91) and the low-level group (TSLP &lt;11.18 pg/ml, N = 84). In a receiver operating characteristic curve analysis, the area under the curve for TSLP as a predictor of AMI was 0.674 with a cut-off value of 9.235 pg/ml. After a median follow-up of 14 months, Kaplan-Meier survival analysis showed no significant difference in MACE-free survival between the two groups (p = 0.648). Finally, the multivariate logistic regression analyses demonstrated that TSLP was a negative predictor of MACE in AMI patients (OR:0.778,95% CI:0.733–0.876, p = 0.032).ConclusionsPlasma TSLP levels were elevated in patients with AMI than those in UA. The lower TSLP concentration was associated with MACE after AMI.
Different Renal Function Patterns in Patients With Acute Heart Failure: Relationship With Outcome and Congestion
Authors: Palazzuoli Alberto , Crescenzi Federico , Luschi Lorenzo , Brazzi Angelica , Feola Mauro , Rossi Arianna , Pagliaro Antonio , Ghionzoli Nicolò , Ruocco Gaetano 
Published: March 2022

BackgroundThe role of worsening renal function during acute heart failure (AHF) hospitalization is still debated. Very few studies have extensively evaluated the renal function (RF) trend during hospitalization by repetitive measurements.ObjectivesTo investigate the prognostic relevance of different RF trajectories together with the congestion status in hospitalized patients.MethodsThis is a post hoc analysis of a multi-center study including 467 patients admitted with AHF who were screened for the Diur-AHF Trial. We recognized five main RF trajectories based on serum creatinine and estimated glomerular filtration rate (eGFR) behavior. According to the RF trajectories our sample was divided into 1-stable (S), 2-transient improvement (TI), 3-permanent improvement (PI), 4-transient worsening (TW), and 5-persistent worsening (PW). The primary outcome was the combined endpoint of 180 days including all causes of mortality and re-hospitalization.ResultsWe recruited 467 subjects with a mean congestion score of 3.5±1.08 and a median creatinine value of 1.28 (1.00–1.70) mg/dl, eGFR 50 (37–65) ml/min/m2 and NTpro B-type natriuretic peptide (BNP) 7,000 (4,200–11,700) pg/ml. A univariate analysis of the RF pattern demonstrated that TI and PW patterns were significantly related to poor prognosis [HR: 2.71 (1.81–4.05); p &lt; 0.001; HR: 1.68 (1.15–2.45); p = 0.007, respectively]. Conversely, the TW pattern showed a significantly protective effect on outcome [HR:0.34 (0.19–0.60); p &lt; 0.001]. Persistence of congestion and BNP reduction ≥ 30% were significantly related to clinical outcome at univariate analysis [HR: 2.41 (1.81–3.21); p &lt; 0.001 and HR:0.47 (0.35–0.67); p &lt; 0.001]. A multivariable analysis confirmed the independently prognostic role of TI, PW patterns, persistence of congestion, and reduced BNP decrease at discharge.ConclusionsVarious RF patterns during AHF hospitalization are associated with different risk(s). PW and TI appear to be the two trajectories related to worse outcome. Current findings confirm the importance of RF evaluation during and after hospitalization.
A Machine Learning-Based Prediction Model for Acute Kidney Injury in Patients With Congestive Heart Failure
Authors: Peng Xi , Li Le , Wang Xinyu , Zhang Huiping 
Published: March 2022

BackgroundMachine learning (ML) has been used to build high performance prediction model. Patients with congestive heart failure (CHF) are vulnerable to acute kidney injury (AKI) which makes treatment difficult. We aimed to establish an ML-based prediction model for the early identification of AKI in patients with CHF.MethodsPatients data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database, and patients with CHF were selected. Comparisons between several common ML classifiers were conducted to select the best prediction model. Recursive feature elimination (RFE) was used to select important prediction features. The model was improved using hyperparameters optimization (HPO). The final model was validated using an external validation set from the eICU Collaborative Research Database. The area under the receiver operating characteristic curve (AUROC), accuracy, calibration curve and decision curve analysis were used to evaluate prediction performance. Additionally, the final model was used to predict renal replacement therapy (RRT) requirement and to assess the short-term prognosis of patients with CHF. Finally, a software program was developed based on the selected features, which could intuitively report the probability of AKI.ResultsA total of 8,580 patients with CHF were included, among whom 2,364 were diagnosed with AKI. The LightGBM model showed the best prediction performance (AUROC = 0.803) among the 13 ML-based models. After RFE and HPO, the final model was established with 18 features including serum creatinine (SCr), blood urea nitrogen (BUN) and urine output (UO). The prediction performance of LightGBM was better than that of measuring SCr, UO or SCr combined with UO (AUROCs: 0.809, 0.703, 0.560 and 0.714, respectively). Additionally, the final model could accurately predict RRT requirement in patients with (AUROC = 0.954). Moreover, the participants were divided into high- and low-risk groups for AKI, and the 90-day mortality in the high-risk group was significantly higher than that in the low-risk group (log-rank p &lt; 0.001). Finally, external validation using the eICU database comprising 9,749 patients with CHF revealed satisfactory prediction outcomes (AUROC = 0.816).ConclusionA prediction model for AKI in patients with CHF was established based on LightGBM, and the prediction performance of this model was better than that of other models. This model may help in predicting RRT requirement and in identifying the population with poor prognosis among patients with CHF.
Effect of Terrigenous Sediment Addition on the Generation of Arc Silicic Magma: Constraints From the Comparative Partial Melting Experiment at 1.5 GPa
Authors: Zang Chunjuan , Wang Mingliang 
Published: March 2022

To assess the effects of sediment addition on the partial melting of subducted oceanic crust and generation of arc silicic magma, a series of comparative partial melting experiments on a garnet plagioamphibolite and a 90 wt% garnet plagioamphibolite + 10 wt% plagioclase slate mixture at 850–1,000°C/1.5 GPa were conducted on a Piston-cylinder apparatus. In the experimental products, partial melt coexists with amphibole + plagioclase + garnet + clinopyroxene at 850–950°C and plagioclase + garnet + clinopyroxene at 1000°C. Compared with pure garnet plagioamphibolite, partial melting of mixture get a higher melting percentage and generates the silicic melt with geochemical characteristics of higher Na2O/K2O and lower Al2O3 in major element and high Rb content in trace element at over 950°C. This result indicates that silicic arc magma may generate from partial melting of metamorphic subducted oceanic crust with sediments thereon, sediment addition contributes to their chemical component and generation dynamic process.
A Review of High-Temperature and High-Pressure Experimental Apparatus Capable of Generating Differential Stress
Authors: Ren Dongsheng , Li Heping 
Published: March 2022

It has been demonstrated that the matters in the earth’s interior are subjected to isotropic hydrostatic pressure and are also extensively superimposed by the differential stress. The differential stress contributes significantly to the free energy of matters and it is the determining factor controlling the composition, structure, configuration, properties, and interaction processes of the matter system. Hence, the differential stress is one of the most fundamental thermodynamic variables governing the earth’s interior system along with the temperature and the hydrostatic pressure. Nevertheless, due to the limitations of high-temperature and high-pressure (HT-HP) setup and in situ measurement techniques as well as limited understanding of the differential stress, previous HT-HP experiments of the earth’s interior didn’t cover the role of the differential stress except for some special stress-strain mechanics experiments and piezolysis and kinetic metamorphism experiments. This makes many of the knowledge about the earth’s interior obtained from HT-HP experiments generally questionable. Currently, HT-HP experimental apparatus that can be used to simulate the temperature, hydrostatic pressure, and differential stress in the earth’s interior includes the Griggs press, the Paterson rheometer, the D-DIA press, the RDA press, and the torsional diamond anvil cell. The maximum hydrostatic pressure that can be simulated in the Griggs press at high temperatures is only about 2 GPa and there is large uncertainty in the calibration of the differential stress. The Paterson rheometer provides too low confining pressure. The D-DIA press and RDA press can simulate a wide range of temperature and pressure but the D-DIA press can achieve very small strain variables and the RDA press has very heterogeneous sample stresses. The torsional diamond anvil cell can only accept a small sample size and it is difficult to calibrate the differential stress. Also, these existing HT-HP experimental apparatus with the differential stress are not easily interfaced with in situ measurement systems for investigating the physical properties such as electrical, ultrasonic, and thermophysical properties. Hence, scholars need to invest more efforts in the research and development of HT-HP apparatus with the differential stress in the future to properly understand the composition, structure, configuration, properties, and interactions of the matter in the earth’s interior.
Down-Regulation Ovulation-Induction Leads to Favorable Outcomes in a Single Frozen-Thawed Blastocyst Transfer RCT
Authors: Chao Shi-Bin , Wang Yan-Hong , Li Jian-Chun , Cao Wen-Ting , Zhou Yun , Sun Qing-Yuan 
Published: March 2022

ObjectiveElective single embryo transfer (eSET) has been increasingly advocated to achieve the goal of delivering a single healthy baby. A novel endometrial preparation approach down-regulation ovulation-induction (DROI) proposed by our team was demonstrated in an RCT that DROI could significantly improve the reproductive outcome compared with modified natural cycle. We aimed to evaluate whether DROI improved clinic pregnancy rate in this single frozen-thawed blastocyst transfer RCT compared with hormone replace treatment (HRT).MethodEligible participants were recruited and randomized into one of two endometrial preparation regimens: DROI or HRT between March 15, 2019 and March 12, 2021. The primary outcome was clinical pregnancy rate (CPR). The secondary endpoints included ongoing pregnancy rate (OPR), biochemical miscarriage and first trimester pregnancy loss. This trial is registered at the Chinese Clinical Trial Registry, number ChiCTR2000039804.Result (s)A total of 330 women were randomized in a 1:1 ratio between two groups and 289 women received embryo transfer and completed the study (142 DROI; 147HRT). Pregnancy outcomes were significantly different between the two groups. The CPR and OPR in the DROI group were significantly higher than those of the HRT group (64.08% versus 46.94%, P&lt;0.01; 56.34% versus 38.78%,P&lt;0.01). The biochemical miscarriage and first trimester pregnancy loss were comparable between the two groups.Conclusion (s)The findings of this RCT support the suggestion that the DROI might be a more efficient and promising alternative endometrial preparation approach for FET. Moreover, DROI could play a critical role in promoting uptake of single embryo transfer strategies in FET.