bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transnational Solidarities and Competing Visions of Europe: Vienna's Vote on the Russo‐Japanese War
Authors: BRANDENBURG ULRICH 
Published: September 2022

AbstractThe 1904–05 Russo‐Japanese War is commonly described as a clash between a European power (Russia) and an Asian one (Japan). This binary framing is problematic, however, as ideas of Europeanness and Asianness were hotly contested during the war. Both Russia and Japan laid claim to being more European than the other, based on competing notions of racial and ideological kinship. The Russo‐Japanese War instantaneously became a first‐rate media event that galvanised audiences worldwide, prompting them to take sides with one or the other of the belligerents. This article examines reactions to the war in the public sphere of Vienna in neutral Austria‐Hungary. It focusses especially on an opinion survey launched by the popular newspaper Illustrirtes Wiener Extrablatt in late February 1904, which attracted more than 12,000 responses and resulted in a narrow victory for Japan. The survey provides us with a valuable sample of ordinary people's voices on the war and reveals that Viennese society was deeply split between solidarity with Russia and with Japan, reflecting the contested socio‐political situation in the city and in the Austro‐Hungarian Empire as a whole. While supporters of Russia excluded Japan from a racially, religiously and geographically defined vision of Europe, supporters of Japan often envisioned a community of civilisation, freedom and justice, which excluded Russia and included Japan. Additionally, competing racisms against ‘yellow’ Japan and Slav Russia reveal substantial disagreement about whether Japan or Russia should be regarded as Europe's Other.
Combined effect of beet powder and lentil flour as a partial nitrite substitute on physicochemical, texture and sensory characteristics, color, and oxidative stability of pork bologna
Authors: Kim Jihan , Shand Phyllis J. 
Published: September 2022

AbstractThe combined effect of beet powder (BP; 0.1%, 0.3%, and 0.5%) and 6% lentil flour (LF) as a partial nitrite substitute on quality attributes of pork bologna incorporated with 7.5% mechanically separated pork during 12 weeks of cold storage was evaluated. A randomized block experimental design with nine treatments and five storage times (0, 3, 6, 9, and 12 weeks) was used for pH, thiobarbituric acid reactive substance, protein oxidation (carbonyl and sulfhydryl), and color parameters. Bologna preparation at a pilot plant scale was replicated three times. LF addition resulted (p < 0.05) in higher viscosity, emulsion stability, and lower expressible drip. Together BP and LF decreased protein oxidation during storage but were not as effective as nitrite with respect to lipid oxidation. Bologna with BP addition showed lower lightness and higher redness, whereas LF increased lightness and decreased redness. A consumer panel rated color acceptability of bologna lower with LF addition, whereas BP raised color acceptability. However, addition of the highest BP level alone to the bologna was negatively perceived as a result of the low acceptability of purge color of the vacuum‐packaged bologna slices. Consequently, the combination of BP and LF could be used to improve eating quality and stability attributes when used as a potential nitrite substitute.
Determination of a clinically effective evobrutinib dose: Exposure–response analyses of a phaseIIrelapsing multiple sclerosis study
Authors: Papasouliotis Orestis , Mitchell David , Girard Pascal , Dangond Fernando , Dyroff Martin 
Published: September 2022

AbstractThe pharmacometric analysis of the double‐blind, randomized, phase II study (NCT02975349) investigating the safety and efficacy of evobrutinib, explored exposure–response relationships and suitable dosing regimens of evobrutinib for relapsing multiple sclerosis. Population pharmacokinetic (PK)/pharmacodynamic modeling was applied to data collected in fasted patients treated with placebo or evobrutinib (25 mg once‐daily [q.d.], 75 mg q.d., or 75 mg twice‐daily [b.i.d.]) for 24 weeks, followed by a 24‐week blinded extension (placebo patients switched to 25 mg q.d.). Model‐based exposures for PK and Bruton's tyrosine kinase occupancy (BTKO) were used for exposure–response analyses (maximum 207 patients). PK, BTKO profiles, and annualized relapse rate (ARR) after 48 weeks of treatment under alternative dosing regimens were simulated. Exposure–response modeling identified a relationship between evobrutinib exposure and clinical response for total number of T1 Gd+ and new/enlarging T2 lesions at weeks 12–24, and ARR at week 48. Area under the concentration–time curve over 24 h at steady‐state (AUC0–24,SS) of 468 and ≥400 ng/ml h was associated with T1 Gd+/T2 lesion reduction and ARR improvement, respectively. These exposures were associated with steady‐state (SS) predose BTKO ≥95%. Based on PK and BTKO profile simulations, evobrutinib 75 mg b.i.d. while fasted is predicted to maintain SS predose BTKO >95% in 92% of patients. Evobrutinib 45 mg b.i.d. with food is predicted to achieve similar exposure as 75 mg b.i.d. while fasted (predose BTKO >95% in 93% of patients). Evobrutinib 45 mg b.i.d. with food is predicted to have comparable exposure and BTKO to 75 mg b.i.d. without food (phase II) and will be pharmacologically effective and appropriate for clinical use in phase III multiple sclerosis studies.
Poderes Judiciales Frente a Sí Mismos: el Caso del Poder Judicial Federal Mexicano
Authors: Ansolabehere Karina 
Published: September 2022

En este artículo analizamos la dinámica del cambio interno de ideas legales en los poderes judiciales. A partir del análisis de la transformación en materia de ideas de derechos humanos que tuvo lugar en el Poder Judicial Federal mexicano entre 2009 y 2018 observamos la importancia de la dinámica del cambio interno para comprender cómo se institucionalizó esta innovación. Proponemos un marco analítico que complementa a otros, enfocados en la región, que enfatizan los detonantes externos del cambio o la importancia del liderazgo judicial individual. El marco analítico construido toma en cuenta el tiempo – dimensión clave en el estudio de los cambios –, e integra dos perspectivas que lo problematizan y que usan otras investigaciones sobre los poderes judiciales: a) la teoría de la difusión, que modeliza al cambio como proceso comunicativo, y b) la aproximación a las dinámicas institucionales desarrolladas por el neoinstituiconalismo histórico que problematiza al cambio desde la distribución del poder. El principal hallazgo derivado de nuestro análisis, al incorporar las novedades que aporta el caso mexicano, es el siguiente: es necesario integrar al estudio de la institucionalización de los cambios en el poder judicial la interrelación entre la comunicación de las nuevas ideas y la distribución del poder interno. El caso mexicano obliga a considerar esta interrelación si se quiere describir con mayor eficacia la evolución y la dinámica de los cambios al interior de los poderes judiciales en América Latina.
PALABRAS CLAVE: Política judicial; cambio judicial; cambio legal; derechos humanos; difusión de innovaciones; cambio institucional.
Epidemiology of sport-related concussion rates in female contact/collision sport: a systematic review
Authors: Walshe Ayrton , Daly Ed , Ryan Lisa 
Published: September 2022

ObjectivesTo determine sport-related concussion (SRC) incidence rates in female contact/collision sport.DesignSystematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.Data sourcesFour databases (PubMed, SportsDiscus, Web of Science, CINAHL) were searched for data from 2012 to 2021.Eligibility criteriaStudies reporting SRC incidence rates or the number of concussions and athletic exposures (AEs) per 1000 participating events or hours in healthy female contact and collision sport athletes of any age were included.ResultsThe search yielded 8438 non-duplicate articles. Following screening, 19 were included in the analysis (median quality score=70%), with 8 reporting match or training incidence rates. Studies were primarily from US high school and collegiate populations; data are reported for eight sports. Rugby union reported the highest match SRC rates (8.2–16.11 per 1000 AE hours), followed by Gaelic football (5.21 per 1000 AE hours) and soccer (2.08–4.04 per 1000 AE events). Where available, match SRC rates were substantially higher than training and overall SRC rates.ConclusionFemale sports such as rugby union, Gaelic football and soccer present the highest risk for SRCs within the available data. Previous research indicates a potentially greater injury burden for female athletes experiencing SRCs than their male counterparts. Thus, future research should analyse concussion knowledge and return-to-play protocols in these sports. Future research should also prioritise exploration of the gap in SRC rates within amateur sports, and data should be presented specifically in the context of athletic exposures (match vs training).Trial registration numberCRD42021281569.
Personal and narrative review of the current management of the injured anterior cruciate ligament of the knee in the UK with reference to surgical treatment versus rehabilitation
Authors: Mowbray Michael Antony Sydee , Ireland John 
Published: September 2022

Rupture of the anterior cruciate ligament of the knee is a common injury occurring mostly in young athletic individuals taking part in pivoting, cutting and jumping sports. It is demonstrated by anterolateral rotatory instability on clinical testing. As yet there are no clear guidelines as to whom will benefit from surgical reconstruction as opposed to rehabilitation alone, apart from elite athletes (defined as varsity players or those participating in sport at national or international level). Also, some adolescent knees and those with combined injuries, usually meniscal tears, may benefit from surgery. Even after surgery there is an increased incidence of rerupture and the development of degenerative changes in the operated knee, particularly in the young athlete who has returned to a high level of sporting activity. Early diagnosis is essential to provide a focused care pathway and to avoid the consequences of chronic cruciate insufficiency.Currently, it seems that too many anterior cruciate ligament reconstructions may be undertaken where rehabilitation alone would have sufficed. Better preoperative clinical testing including improved arthrometric assessment, muscle and neurological testing and imaging including radiology and MRI may help refine the diagnosis, thus enabling a better decision on further management. There is also a requirement for better designed clinical studies reporting on the outcomes of treatment be it either surgical or conservative.
Distinct Cell Adhesion Signature Defines Glioblastoma Myeloid-Derived Suppressor Cell Subsets
Authors: Bayik Defne , Bartels Cynthia F. , Lovrenert Katreya , Watson Dionysios C. , Zhang Duo , Kay Kristen , Lee Juyeun , Lauko Adam , Johnson Sadie , Lo Alice , Silver Daniel J. , McGraw Mary , Grabowski Matthew , Mohammadi Alireza M. , Veglia Filippo , Fan Yi , Vogelbaum Michael A. , Scacheri Peter , Lathia Justin D. 
Published: September 2022

Abstract

In multiple types of cancer, an increased frequency in myeloid-derived suppressor cells (MDSC) is associated with worse outcomes and poor therapeutic response. In the glioblastoma (GBM) microenvironment, monocytic (m) MDSCs represent the predominant subset. However, the molecular basis of mMDSC enrichment in the tumor microenvironment compared with granulocytic (g) MDSCs has yet to be determined. Here we performed the first broad epigenetic profiling of MDSC subsets to define underlying cell-intrinsic differences in behavior and found that enhanced gene accessibility of cell adhesion programs in mMDSCs is linked to their tumor-accelerating ability in GBM models upon adoptive transfer. Mouse and human mMDSCs expressed higher levels of integrin β1 and dipeptidyl peptidase-4 (DPP-4) compared with gMDSCs as part of an enhanced cell adhesion signature. Integrin β1 blockade abrogated the tumor-promoting phenotype of mMDSCs and altered the immune profile in the tumor microenvironment, whereas treatment with a DPP-4 inhibitor extended survival in preclinical GBM models. Targeting DPP-4 in mMDSCs reduced pERK signaling and their migration towards tumor cells. These findings uncover a fundamental difference in the molecular basis of MDSC subsets and suggest that integrin β1 and DPP-4 represent putative immunotherapy targets to attenuate myeloid cell-driven immune suppression in GBM.

Significance:
Epigenetic profiling uncovers cell adhesion programming as a regulator of the tumor-promoting functions of monocytic myeloid-derived suppressor cells in glioblastoma, identifying therapeutic targets that modulate the immune response and suppress tumor growth.
Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer
Authors: Riesenberg Brian P. , Hunt Elizabeth G. , Tennant Megan D. , Hurst Katie E. , Andrews Alex M. , Leddy Lee R. , Neskey David M. , Hill Elizabeth G. , Rivera Guillermo O. Rangel , Paulos Chrystal M. , Gao Peng , Thaxton Jessica E. 
Published: September 2022

Abstract

Protein synthesis supports robust immune responses. Nutrient competition and global cell stressors in the tumor microenvironment (TME) may impact protein translation in T cells and antitumor immunity. Using human and mouse tumors, we demonstrated here that protein translation in T cells is repressed in solid tumors. Reduced glucose availability to T cells in the TME led to activation of the unfolded protein response (UPR) element eIF2α (eukaryotic translation initiation factor 2 alpha). Genetic mouse models revealed that translation attenuation mediated by activated p-eIF2α undermines the ability of T cells to suppress tumor growth. Reprograming T-cell metabolism was able to alleviate p-eIF2α accumulation and translational attenuation in the TME, allowing for sustained protein translation. Metabolic and pharmacological approaches showed that proteasome activity mitigates induction of p-eIF2α to support optimal antitumor T-cell function, protecting from translation attenuation and enabling prolonged cytokine synthesis in solid tumors. Together, these data identify a new therapeutic avenue to fuel the efficacy of tumor immunotherapy.

Significance:
Proteasome function is a necessary cellular component for endowing T cells with tumor killing capacity by mitigating translation attenuation resulting from the unfolded protein response induced by stress in the tumor microenvironment.
Associations between Serum 25-Hydroxyvitamin D Levels and Health-Related Quality-of-Life Measures in Patients with Breast Cancer: A Longitudinal Study
Authors: Cross Temara , George Anthony , Attwood Kristopher , Zhang Yali , O'Connor Tracey L. , Barone Nancy , Hulme Karen , Ambrosone Christine B. , Yao Song , Hong Chi-Chen 
Published: September 2022

AbstractBackground:Recent evidence suggests that vitamin D might lower breast cancer mortality. There is also growing interest in vitamin D's potential association with health-related quality-of-life (HRQoL). Associations between circulating 25-hydroxyvitamin D (25OHD) concentrations and HRQoL were examined prospectively among breast cancer survivors at the time of diagnosis and 1 year later.Methods:504 women with incident early-stage breast cancer at Roswell Park Comprehensive Cancer Center were included, and 372 patients provided assessments 1 year later. At each timepoint, participants provided blood samples and completed the SF-36 Health Survey, and surveys on perceived stress, depression, and fatigue. Season-adjusted serum 25OHD concentrations were analyzed in relation to HRQoL measures using multivariable logistic regression models.Results:Approximately 32% of participants had deficient vitamin D levels at diagnosis, which decreased to 25% at 1 year. Concurrently, although SF-36 physical health summary scores were lower at 1 year, mental health summary scores improved, and levels of depression and perceived stress were lower. In comparison with women with sufficient 25OHD levels (&gt;30 ng/mL) at diagnosis, those who were deficient (&lt;20 ng/mL) had significantly worse HRQoL at diagnosis and 1 year later. Vitamin D deficiency 1 year post-diagnosis was also associated with worse HRQoL, particularly among breast cancer survivors who took vitamin D supplements.Conclusions:Breast cancer survivors with vitamin D deficiency were more likely to report lower HRQoL than those with sufficient levels at the time of diagnosis and 1 year post-diagnosis.Impact:Our results indicate a potential benefit of vitamin D supplementation for improving breast cancer survivorship.
Prevalence of Monoclonal Gammopathy of Undetermined Significance in Black South African Men
Authors: Cicero Kara I. , Joffe Maureen , Patel Moosa , Chiuzan Codruta , Pentz Audrey , Ruff Paul , Lentzsch Suzanne , Leng Siyang , Jacobson Judith S. , Rebbeck Timothy R. , Neugut Alfred I. 
Published: September 2022

Abstract

Background:
Both multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance (MGUS), occur twice as often within Black compared with White populations, suggesting that racial disparities lie within the development of MGUS. Nonetheless, MGUS has been studied mainly in White cohorts; the study that first described the natural history of MGUS was conducted in 97.3% White Olmsted County, Minnesota.

Methods:
We determined the prevalence of MGUS among 386 Black South African (SA) men &gt;30 years at Chris Hani Baragwanath Hospital in Johannesburg. We conducted serum protein electrophoresis and free light chain quantification to define MGUS by the same criteria as the Olmsted County studies. We also investigated the association between MGUS and various clinical factors, including human immunodeficiency virus (HIV) infection and smoking.

Results:
We found the prevalence of MGUS to be 8.03% [95% confidence interval (CI), 5.32–10.74], nearly 1.6-fold higher than in the White Olmsted County male population. In a univariable logistic regression model, MGUS was associated with HIV status (OR, 2.39; 95% CI, 0.95–5.49), but in an adjusted model that included body mass index and cigarette use, the association was not statistically significant. Those who were current (vs. never) cigarette smokers were more likely to have MGUS in both univariable (OR, 5.60; 95% CI, 2.16–17.42) and multivariable models (OR, 4.49; 95% CI, 1.63–14.56).

Conclusions:
The prevalence of MGUS in Black SA men is substantially higher than in White populations and may be associated with HIV status and cigarette use.

Impact:
Racial disparities in MGUS exist and may be associated with potentially modifiable risk factors.
Teatro em Tempos do Holocausto: Espaço de Resistência Contra a Intolerância
Authors: Marko Leslie 
Published: September 2022

Esta comunicação apresenta alguns resultados da pesquisa de doutorado sobre o movimento de resistência sustentado por artistas, atores, diretores, autores e espectadores durante o período em que o nazifascismo dominou grande parte da Europa (1939-1945). A relevância deste estudo está em analisar a atuação de um artista, Sami Feder, que buscou o exercício ético do acolhimento coletivo e da cidadania, por meio da arte. Ações intervencionistas como estas propagaram-se pelas cidades ocupadas, guetos e campos de concentração enquanto reação ao processo de desumanização sustentado pelo Estado nacional-socialista e países colaboracionistas
Association of Lifestyle With Incidence of Heart Failure According to Metabolic and Genetic Risk Status: A Population-Based Prospective Study
Authors: Zhu Zhengbao , Li Fu-Rong , Jia Yiming , Li Yang , Guo Daoxia , Chen Jingsi , Tian Haili , Yang Jing , Yang Huan-Huan , Chen Li-Hua , Zhang Kaixin , Yang Pinni , Sun Lulu , Shi Mengyao , Zhang Yonghong , Qin Li-Qiang , Chen Guo-Chong 
Published: September 2022

Background:
Whether lifestyle factors are similarly associated with risk of heart failure (HF) for individuals with different metabolic or genetic risk status remains unclear.

Methods:
We included 464 483 participants from UK Biobank who were free of major cardiovascular disease or HF during baseline recruitment. Healthy lifestyle factors included avoidance of smoking, no obesity, regular physical activity, and healthy diet. Lifestyle was categorized as favorable (3 or 4 healthy lifestyle factors), intermediate (2 healthy lifestyle factors), and unfavorable (0 or 1 healthy lifestyle factor) lifestyles. Metabolic status was defined by the presence of hypertension, high total cholesterol, or diabetes at baseline. A weighted genetic risk score was created based on 12 single-nucleotide polymorphisms associated with HF.

Results:

Compared with favorable lifestyle, the multivariable-adjusted hazard ratios of HF were 1.79 (95% CI, 1.68–1.90) and 2.90 (95% CI, 2.70–3.11) for intermediate lifestyle and unfavorable lifestyle, respectively (
P
trend
<0.0001). This association was largely consistent regardless of the presence of any single metabolic risk factor or the number of metabolic risk factors (
P
interaction
≥0.21). The association was also similar across different genetic risk categories (
P
interaction
=0.92). In a joint analysis, the hazard ratio of HF was 4.05 (95% CI, 3.43–4.77) comparing participants who had both higher genetic risk and an unfavorable lifestyle with those having lower genetic risk and a favorable lifestyle.

Conclusions:
Combined lifestyle was associated with incident HF regardless of metabolic or genetic risk status, supporting the recommendation of healthy lifestyles for HF prevention across the entire population.
Victorinus of Pettau and Angelomorphic Theological Traditions
Authors: McCashen Grayden 
Published: September 2022

Abstract
Victorinus of Pettau is often read either as one of many binitarian Latin theologians in the ante-Nicene era or as a simple exegete whose imprecise comments on the relationship between the Word and Spirit are characteristic of his time. This study argues that recent research on “angelomorphic” theology in sources like Revelation and Clement of Alexandria and the reinterpretation of those traditions in Origen offers a new context in which to situate Victorinus. Read in this context, Victorinus’ comments on the Spirit of sevenfold power and the Word imply a more sophisticated and coherent understanding of the Holy Spirit and the Spirit’s relationship with the Word than is usually thought.