bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Efficient Rechargeable Aluminium–Amine Battery Working Under Quaternization Chemistry
Authors: Wang Gang , Dmitrieva Evgenia , Kohn Benjamin , Scheler Ulrich , Liu Yannan , Tkachova Valeriya , Yang Lin , Fu Yubin , Ma Ji , Zhang Panpan , Wang Faxing , Ge Jin , Feng Xinliang 
Published: January 2022

AbstractRechargeable aluminium (Al) batteries (RABs) have long‐been pursued due to the high sustainability and three‐electron‐transfer properties of Al metal. However, limited redox chemistry is available for rechargeable Al batteries, which restricts the exploration of cathode materials. Herein, we demonstrate an efficient Al–amine battery based on a quaternization reaction, in which nitrogen (radical) cations (R3N.+ or R4N+) are formed to store the anionic Al complex. The reactive aromatic amine molecules further oligomerize during cycling, inhibiting amine dissolution into the electrolyte. Consequently, the constructed Al–amine battery exhibits a high reversible capacity of 135 mAh g−1 along with a superior cycling life (4000 cycles), fast charge capability and a high energy efficiency of 94.2 %. Moreover, the Al–amine battery shows excellent stability against self‐discharge, far beyond conventional Al–graphite batteries. Our findings pave an avenue to advance the chemistry of RABs and thus battery performance.
Catalytic Enantioconvergent Allenylation of Aldehydes with Propargyl Halides
Authors: Zhang Feng‐Hua , Guo Xiaochong , Zeng Xianrong , Wang Zhaobin 
Published: January 2022

Abstractα‐Allenol is a versatile synthon in organic synthesis. The catalytic asymmetric synthesis of α‐allenols from readily available starting materials remains a prominent challenge, especially when simultaneous control over axial and central chirality is required. Herein, we describe the Cr‐catalyzed enantioconvergent allenylation of aldehydes with racemic propargyl halides to rapidly access a wide range of chiral α‐allenols with adjacent axial and central chiralities. This method features excellent regio‐, diastereo‐ and enantioselectivity control with broad substrate scope, and provides facile access to all four stereoisomers when allied with a Mitsunobu reaction. Preliminary mechanistic studies support radical‐based reaction pathways. The synthetic utility is demonstrated by the application in late‐stage functionalization and the formal total synthesis of (+)‐varitriol.
Identification of organophosphate modifications by high‐resolution mass spectrometry
Authors: Lee Jun Hyung , Jang Wooyoung Eric , Park Ji Hwan , Mohammad Hazara Begum , Lee Jin‐Young , Jeong Woo‐Hyeon , Kim Min‐Sik 
Published: January 2022

AbstractOrganophosphate (OP) compounds exhibit neurotoxicity by binding to serine residues of acetylcholinesterase (AChE) in the cholinergic nervous system and subsequently lead to the accumulation of acetylcholine in neuromuscular junctions of synapses. AChE capable of hydrolyzing choline esters is known to be inhibited in patients with nerve agents poisoning. Since OP is known to be transported by covalent bonding to human serum albumin (HSA), OP‐HSA adducts are considered potential diagnostic markers for OP exposures. In this study, HSA modification sites by OP or OP‐like compounds such as V‐type (VX) and Novichok‐type (A234), insecticide (DFP), and serine protease inhibitor (PMSF) were studied using liquid chromatography‐high‐resolution tandem mass spectrometry. As a result, we have discovered a novel OP‐HSA modification site, Y341.
Development of a bioanalytical method for the quantification of sinococuline in human plasma and its application in phase I clinical pharmacokinetic study
Authors: Bhadaliya Chetan , Panigrahy Bala Krishna , Goswami Dipanjan , Maiti Sovan , Gurule Sanjay Jagannath , Khuroo Arshad H. 
Published: January 2022

AbstractA selective, highly sensitive, precise, and novel bioanalytical method has been developed and validated to quantify sinococuline, an active constituent present in the phytopharmaceutical drug product containing Cocculus hirsutus plant extract, in vivo. Chromatographic separation was achieved on a Luna Omega Polar‐C18 bonded analytical column maintained at 45°C. The isocratic mobile phase consisted of methanol and ammonium formate buffer (60:40, v/v) at acidic pH with a low flow rate of 0.250 mL/min. Detection was performed on an API 4000 mass spectrometer using electrospray ionization in positive polarity and multiple reaction monitoring mode to achieve a lower limit of quantification of 1.50 ng/mL. Excellent accuracy and precision were obtained after extracting the analyte from plasma samples using a chemical analogue as an internal standard in the absence of an isotope‐labeled compound. The extraction efficacy was evidenced from recovery study, and the analyte was found to be stable in plasma. Validation study demonstrated linearity with coefficient of correlation, r ≥ 0.99, and minimal matrix effect. This bioanalytical method was successfully applied to evaluate pharmacokinetic parameters of sinococuline from a phase I clinical trial of an aqueous extract of C. hirsutus in healthy human volunteers.
Modulating intrinsic functional connectivity with visual cortex using low‐frequency repetitive transcranial magnetic stimulation
Authors: Rafique Sara A. , Steeves Jennifer K. E. 
Published: January 2022

AbstractIntroductionIntrinsic network connectivity becomes altered in pathophysiology. Noninvasive brain stimulation can modulate pathological functional networks in an attempt to restore the inherent response. To determine its usefulness for visual‐related disorders, we developed procedures investigating repetitive transcranial magnetic stimulation (rTMS) protocols targeting the visual cortex on modulating connectivity associated with the visual network and default mode network (DMN).MethodsWe compared two low‐frequency (1 Hz) rTMS protocols to the visual cortex (V1)—a single 20 min session and five successive 20 min sessions (accelerated/within‐session rTMS)—using multi‐echo resting‐state functional magnetic resonance whole‐brain imaging and resting‐state functional connectivity (rsFC). We also explored the relationship between rsFC and rTMS‐induced changes in key inhibitory and excitatory neurotransmitters, γ‐aminobutyric acid (GABA) and glutamate. GABA (GABA+) and glutamate (Glx) concentrations were measured in vivo using magnetic resonance spectroscopy.ResultsAcute disruption with a single rTMS session caused widespread connectivity reconfiguration with nodes of interest. Changes were not evident immediately post‐rTMS but were observed at 1 h post‐rTMS. Accelerated sessions resulted in weak alterations in connectivity, producing a relatively homeostatic response. Changes in GABA+ and Glx concentrations with network connectivity were dependent on the rTMS protocol.ConclusionsThis proof‐of‐concept study offers new perspectives to assess stimulation‐induced neural processes involved in intrinsic functional connectivity and the potential for rTMS to modulate nodes interconnected with the visual cortex. The differential effects of single‐session and accelerated rTMS on physiological markers are crucial for furthering the advancement of treatment modalities in visual cortex related disorders.
How does green intellectual capital boost performance? The mediating role of environmental performance measurement systems
Authors: Asiaei Kaveh , Jusoh Ruzita , Barani Omid , Asiaei Arash 
Published: January 2022

AbstractThis paper draws on the newly developed notion of “natural resource orchestration” to propose and test a framework that shows how the use of environmental performance measurement systems mobilizes green intellectual capital to influence organizational performance. More precisely, this study examines to what extent companies place emphasis on the use of environmental performance measurement to translate green intellectual capital into enhanced organizational performance in terms of both economic and environmental performance. Based on a survey of 105 Iranian public listed companies, the results show that two elements of green intellectual capital, namely, green human capital and green structural capital are positively associated with both environmental performance measurement use and environmental performance. In contrast, green relational capital affects environmental performance only in the presence of environmental performance measurement as a mediating variable. By embedding the resource orchestration theory in the management accounting and intellectual capital settings, this study contributes to the existing literature and sheds light on the issue of how companies need to synchronize their green resources with proper organizational control systems to reap the maximum benefits of those green strategic resources.
Retinal ganglion cells expressing CaM kinase II in human and nonhuman primates
Authors: Baldicano Alyssa K. , Nasir‐Ahmad Subha , Novelli Mario , Lee Sammy C.S. , Do Michael Tri H. , Martin Paul R. , Grünert Ulrike 
Published: January 2022

AbstractImmunoreactivity for calcium‐/calmodulin‐dependent protein kinase II (CaMKII) in the primate dorsal lateral geniculate nucleus (dLGN) has been attributed to geniculocortical relay neurons and has also been suggested to arise from terminals of retinal ganglion cells. Here, we combined immunostaining with single‐cell injections to investigate the expression of CaMKII in retinal ganglion cells of three primate species: macaque (Macaca fascicularis, M. nemestrina), human, and marmoset (Callithrix jacchus). We found that in all species, about 2%–10% of the total ganglion cell population expressed CaMKII. In all species, CaMKII was expressed by multiple types of wide‐field ganglion cell including large sparse, giant sparse (melanopsin‐expressing), broad thorny, and narrow thorny cells. Three other ganglion cells types, namely, inner and outer stratifying maze cells in macaque and tufted cells in marmoset were also found. Double labeling experiments showed that CaMKII‐expressing cells included inner and outer stratifying melanopsin cells. Nearly all CaMKII‐expressing ganglion cell types identified here are known to project to the koniocellular layers of the dLGN as well as to the superior colliculus. The best characterized koniocellular projecting cell type—the small bistratified (blue ON/yellow OFF) cell—was, however, not CaMKII‐positive in any species. Our results indicate that the pattern of CaMKII expression in retinal ganglion cells is largely conserved across different species of primate suggesting a common functional role. But the results also show that CaMKII is not a marker for all koniocellular projecting retinal ganglion cells.
Isolation of Extracellular Vesicles from Arabidopsis
Authors: Chen Angela , He Baoye , Jin Hailing 
Published: January 2022

AbstractExtracellular vesicles (EVs) in plants have emerged as key players in cell‐to‐cell communication and cross‐kingdom RNAi between plants and pathogens by facilitating the exchange of RNA, proteins, and other molecules. In addition to their role in intercellular communication, plant EVs also show promise as potential therapeutics and indicators of plant health. However, plant EVs exhibit significant heterogeneity in their protein markers, size, and biogenesis pathways, strongly influencing their composition and functionality. While mammalian EVs can be generally classified as exosomes that are derived from multivesicular bodies (MVBs), microvesicles that are shed from the plasma membrane, or as apoptotic bodies that originate from cells undergoing apoptosis, plant EVs remain poorly studied in comparison. At least three subclasses of EVs have been identified in Arabidopsis leaves to date, including Tetraspanin‐positive exosomes derived from MVBs, Penetration 1 (PEN1)‐positive EVs, and EVs derived from exocyst‐positive organelles (EXPO). Differences in the plant starting material and isolation techniques have resulted in different purities, quality, and compositions of the resulting EVs, complicating efforts to better understand the role of these EVs in plants. We performed a comparative analysis on commonly used plant EV isolation methods and have identified an effective protocol for extracting clean apoplastic washing fluid (AWF) and isolating high‐quality intact and pure EVs of Arabidopsis thaliana. These EVs can then be used for various applications or studied to assess their cargos and functionality in plants. Furthermore, this process can be easily adapted to other plant species of interest. © 2022 Wiley Periodicals LLC.Basic Protocol 1: Isolation of EVs from the apoplastic fluid of Arabidopsis thalianaBasic Protocol 2: Density gradient fractionation of EVsBasic Protocol 3: Immuno‐isolation of EVs using Arabidopsis tetraspanin 8 (TET8) antibody
Coffea arabica rootstock resistant to Meloidogyne paranaensis nematodes
Authors: Azevedo Lillian Magalhães , Andrade Francisco Hélio Alves de , Acosta Lermen Forigua , Santos Jacqueline Oliveira dos , Pacheco Paulo Victor Magalhães , Marchiori Paulo Eduardo Ribeiro , Castro Evaristo Mauro de , Carvalho Gladyston Rodrigues , Salgado Sônia Maria de Lima , Silva Vânia Aparecida 
Published: January 2022

AbstractMeloidogyne paranaensis is a species of root‐knot nematode that affects coffee (Coffea arabica L.) tree growth by causing severe damages to the plant root. This study evaluated the agronomic performance of Coffea arabica progenies in an M. paranaensis‐infested field and assessed the compatibility of resistant C. arabica genotype 28‐I‐4 (GEN28) as rootstock for susceptible cultivars. Experiment 1: under field conditions, six progenies were analyzed; the controls were ‘IPR100’ as resistant and ‘Catuaí Vermelho IAC 144’ (CtV144) as susceptible. Experiment 2: under greenhouse conditions, combinations of grafts and rootstocks between susceptible CtV144 and GEN28 were evaluated regarding their resistance to M. paranaensis alongside their noninoculated counterparts. For this, M. paranaensis reproduction factor (RF), total population of the nematode per gram of root system, growth parameters, gas exchange, and water potential (ψpd) were evaluated. In Experiment 1, resistant C. arabica progenies were more vigorous, productive, and showed a population of M. paranaensis threefold‐times lower than that observed in roots of susceptible CtV144. Among the resistant progenies selected in the field experiment, GEN28 was chosen for physiological compatibility study with the traditional cultivar CtV144. In Experiment 2, the CtV144 grafted onto GEN28 led to resistance to M. paranaensis, as well as a higher leaf area and ψpd as compared with nongrafted CtV144. Therefore, the GEN28 holds suitable characteristics to be used as a new Coffea arabica rootstock applied to production of resistant seedlings to Meloidogyne paranaensis nematodes. This technology represents an alternative to keep up coffee activity in infested areas.
Large‐scale, multidecade monitoring data from kelp forest ecosystems in California and Oregon (USA)
Authors: Malone Daniel P. , Davis Kathryn , Lonhart Steve I. , Parsons‐Field Avrey , Caselle Jennifer E. , Carr Mark H. 
Published: January 2022

AbstractKelp forests are among the most productive ecosystems on Earth. In combination with their close proximity to the shore, the productivity and biodiversity of these ecosystems generate a wide range of ecosystem services including supporting (e.g., primary production, habitat), regulating (e.g., water flow, coastal erosion), provisioning (e.g., commercial and recreational fisheries), and cultural (e.g., recreational, artisanal) services. For these reasons, kelp forests have long been the target of ecological studies. However, with few exceptions, these studies have been localized and short term (<5 years). In 1999, recognizing the importance of large‐scale, long‐term studies for understanding the structure, functioning, and dynamics of coastal marine ecosystems, and for informing policy, the Partnership for Interdisciplinary Studies of Coastal Oceans (PISCO) designed and initiated a large‐scale, long‐term monitoring study of kelp forest ecosystems along 1400 km of coast stretching from southern California to southern Oregon, USA. The purpose of the study has been to characterize the spatial and temporal patterns of kelp forest ecosystem structure and evaluate the relative contributions of biological and environmental variables derived from external sources (e.g., sea otter density, Chl‐a concentration, sea surface temperature, wave energy) in explaining observed spatial and temporal patterns. For this purpose, the ecological community (i.e., density, percent cover, or biomass of conspicuous fishes, invertebrates, and macroalgae) and geomorphological attributes (bottom depth, substratum type, and vertical relief) of kelp forest ecosystems have been surveyed annually using SCUBA divers trained in both scientific diving and data collection techniques and the identification of kelp forest species. The study region spans distinct ecological and biogeographic provinces, which enables investigations of how variation in environmental drivers and distinctive species compositions influence community structure, and its response to climate‐related environmental change across a portion of the California Current Large Marine Ecosystem. These data have been used to inform fisheries management, design and evaluate California's state‐wide network of marine protected areas (MPAs), and assess the ecological consequences of climate change (e.g., marine heatwaves). Over time, the spatial and temporal design of the monitoring program was adapted to fill its role in evaluating the ecological responses to the establishment of MPAs. There are no copyright restrictions; please cite this paper when data are used.
Isoprostanoids, Isofuranoids and Isoketals – From Synthesis to Lipidomics
Authors: Vigor Claire , Balas Laurence , Guy Alexandre , Bultel‐Poncé Valérie , Reversat Guillaume , Galano Jean‐Marie , Durand Thierry , Oger Camille 
Published: January 2022

AbstractA huge diversity of oxygenated metabolites originated from polyunsaturated fatty acids (PUFAs) had been discovered. Radical cascades are involved in the biosynthesis of these metabolites, and the radical initiation can be performed either inside the active site of an enzyme in the extracellular medium, or in membrane on phospholipids. The development of convergent and flexible chemical strategies to prepare these compounds by organic chemists, along with the development of sophisticated mass spectrometry methods, has boosted the knowledge regarding PUFA metabolites. Also, isoprostanoids have emerged as indicators of oxidative stress in humans and their environment. This Review provides a brief overview on the chemical strategies and analytical methods achieved over the past thirty years.
A case study exploring the impact of JCI standards implementation on staff productivity and motivation at the laboratory and blood bank
Authors: Tarieh Rima Ramzi Abou , Zayyat Ramez , Naoufal Rania Nazir , Samaha Hanady Rafic 
Published: January 2022

AbstractBackground and AimsQuality of care has transformed to become an essential element of healthcare service delivery, which caused decision makers in Health Care Organisations (HCOs) to seek methods to evaluate the level of care provided. The field of accreditation is under massive development, especially in healthcare organizations. Joint Commission International (JCI) accreditation is one of the accreditation bodies that require a lot of documentation and quality improvement to guarantee proper standard application. The process of accreditation is known to be demanding and requires staff involvement to guarantee successful implementation.MethodsThis study focuses on the impact of JCI standards implementation on staff productivity and motivation in a 350‐bed hospital. An interpretive approach was used to collect empirical data by interpreting the population's behavior, which is represented in this study by the questionnaire. The study is considered an emergent study that identified, explained, illustrated, and developed a model of staff motivation. In this type of study, the process of inquiry, supporting arguments, and questions of interest is developed after the launching of the study and during the process of data collection. Thus, the researcher relied on the social constructive paradigm, whereby the grounded theory (GT) is used to build the research model of staff motivation during the process of accreditation.ResultsBy studying the Turn Around Time (TAT) performance indicator, the study showed that TAT of tests decreased by 3% after JCI standards implementation, which was reflected at two different laboratory sections. The trainings conducted throughout the process of standards implementation also resulted in enhancing the quality of samples, which was demonstrated by the decrease in the percentage of rejected samples.ConclusionStaff productivity increases when JCI standards are implemented. However, staff motivation is dependent on their involvement with management decisions and the smooth transition through change management, which ensures staff retention and therefore increase productivity.
Measuring morality in infancy: A scoping methodological review
Authors: Lavoie Jennifer , Murray Aja L. , Skinner Guy , Janiczek Emilia 
Published: January 2022

AbstractWe conducted a scoping review of methods that have been used to measure infants' (under age 2) moral development. We aimed to assess the state of knowledge through a thematic overview of the methodologies that have been used and the specific constructs studied. We found that the majority of studies used an experimental methodology, and within this, infants' actual behaviour and their evaluations were the most common sources of information. An evidence map depicting concept delineation between studies and presenting concepts as related to an underlying moral sense, as prosocial (emotion and behaviour), and as antisocial components (emotion and behaviour) is provided. Just under one‐third of studies were longitudinal, and a high percentage reported a statistically significant longitudinal relation for moral development. Results highlight a need for measures that can be used longitudinally at different stages of development so that trajectories can be observed and mapped to behavioural outcomes, such as conduct problems.