bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining the effects of tencha‐ro drying on key volatile compounds in tencha (Camellia sinensis) through gas chromatography–mass spectrometry
Authors: Xiao Zhipeng , Zhang Wenjun , Guo Wenli , Zhang Lan , Huang Ai , Tao Meng , Li Meiqin , Su Rui , Liu Zhengquan 
Published: July 2022

AbstractDrying is the key process through which the aroma of tencha forms. However, the effects of drying method on volatiles are unknown. We compared tencha‐ro drying with regular drying. Volatiles in tencha infusions were extracted using headspace solid‐phase microextraction and solvent‐assisted flavor evaporation combined with gas chromatography–mass spectrometry. Partial least squares (PLS), odor activity value (OAV), and heat map analyses were performed to identify the optimal drying method for creating a seaweed‐like aroma. Changes in the key volatile compounds of the samples were investigated. The tencha infusions contained 125 volatiles with nine chemical structures. According to the sensory evaluation, tencha‐ro drying was the optimal method for producing high‐quality tencha with an intense and consistent seaweed‐like aroma. The PLS model accurately distinguished among the types of tencha. By combining OAVs with screening through multivariate statistical analysis, six volatile compounds were revealed to contribute substantially to tencha's seaweed‐like aroma: 2‐ethyl‐3,5‐dimethylpyrazine, 2‐ethyl‐6‐methylpyrazine, 2‐ethyl‐5‐methylpyrazine, dimethyl sulfide, β‐ionone, and 2‐formyl‐1‐methylpyrrole. The findings provide a theoretical basis and technical guidance for the processing of high‐quality tencha with a strong seaweed‐like aroma.Practical ApplicationThis study demonstrated that tencha‐ro drying contributes to the formation of a seaweed‐like aroma in tencha and provides theoretical guidance for tea factories to use the appropriate drying methods for high‐quality tencha.
Self‐control impacts symptoms defining Internet gaming disorder through dorsal anterior cingulate–ventral striatal pathway
Authors: Gong Liangyu , Zhou Hui , Su Conghui , Geng Fengji , Xi Wan , Teng Binyu , Yuan Kai , Zhao Min , Hu Yuzheng 
Published: July 2022

AbstractSelf‐control is important for long‐term success and could be a protective factor against maladaptive behaviours such as excessive gaming activity or Internet gaming disorder (IGD). However, the neurobiological basis of self‐control and its relationship to IGD remain elusive. Using resting‐state fMRI data from 89 participants aged from 18 to 26, we found that self‐control and the number of IGD symptoms (IGD‐S) were positively and negatively correlated with functional connectivity between right ventral striatum (rVS) and dorsal anterior cingulate cortex (dACC), respectively. A mediation analysis indicated that self‐control influenced IGD‐S partially through the rVS‐dACC connectivity. In addition, step‐wise regression analyses revealed that the rVS connectivity in a reward‐anticipation limbic pathway contributed to IGD‐S but not self‐control, independent of the dACC pathway. These results suggest that the cingulate–ventral striatal functional connectivity may serve as an important neurobiological underpinning of self‐control to regulate maladaptive behaviours such as these manifesting IGD through striatal circuitry balance.
Percreta score to differentiate between placenta accreta and placenta percreta with ultrasound and MR imaging
Authors: Pain Flore‐Anne , Dohan Anthony , Grange Gilles , Marcellin Louis , Uzan‐Augui Joëlle , Goffinet François , Soyer Philippe , Tsatsaris Vassilis 
Published: July 2022

AbstractIntroductionThe objective of this study was to assess the performance of ultrasound and magnetic resonance imaging (MRI) features in helping to classify the type of placenta accreta spectrum (PAS; accreta/increta vs percreta), alone or combined in a predictive score.Material and MethodsWe conducted a retrospective study in 82 pregnant women with PAS who underwent ultrasound and MRI examination of the pelvis before delivery (from an initial cohort of 185 women with PAS). We estimated the sensitivity, specificity and accuracy of MRI and ultrasound in the diagnosis of the type of PAS. We analyzed cesarean and imaging features using univariable logistic regression analysis. We constructed a nomogram to predict the risk of placenta percreta and validated it with bootstrap resampling, then used receiver operating characteristic curves to assess the performance of the model in distinguishing between placenta percreta and placenta accreta/increta.ResultsAmong the 82 patients, 29 (35%) had placenta accreta/increta and 53 (65%) had placenta percreta. The best features to discriminate between placenta accreta/increta and placenta percreta with ultrasound were increased vascularization at the uterine serosa–bladder wall interface (odds ratio [OR] 7.93; 95% confidence interval [CI] 2.78–24.99; p < 0.01) and the number of lacunae without a hyperechogenic halo (OR 1.36; 95% CI 1.14–1.67; p = 0.012). Concerning MRI markers, heterogeneous placenta (OR 12.89; 95% CI 3.05–89.16; p = 0.002), dark intraplacental bands (OR 12.89; 95% CI 3.05–89.16; p = 0.002) and bladder wall interruption (OR 15.89; 95% CI 4.78–73.33; p < 0.001) had a higher OR in discriminating placenta accreta/increta from placenta percreta. The nomogram yielded areas under the curve of 0.841 (95% CI 0.754–0.927) and 0.856 (95% CI 0.767–0.945), after bootstrap resampling, for the accurate prediction of placenta percreta.ConclusionsThe nomogram we developed to predict the risk of placenta percreta among patients with PAS had good discriminative capabilities. This performance and its impact on maternal morbidity should be confirmed by future prospective studies.
miR‐21, miR‐125b, and let‐7b contribute to the involution of atretic follicles and corpus lutea in Tibetan sheep ovaries
Authors: Zhang Taojie , Huo Shengdong , Wei Suocheng , Cui Sheng 
Published: July 2022

AbstractFollicular granulosa cells (FGCs) are crucial for ovarian follicle functions, and miRNAs are differentially expressed at various stages of follicular developments. In this study, we confirmed that miR‐21, miR‐125b, and let‐7b were located in FGCs/luteal cells by in situ hybridization experiments. Moreover, miR‐21 and miR‐125b expressions were upregulated in late corpus lutea (CL) and atretic follicles (AF); let‐7b expression was increased in early AF. After transfected with inhibitor or mimic of miRNAs in FGCs, we found that FGCs apoptosis was decreased in the miR‐21‐mi group but increased in the miR‐125b‐mi group using flow cytometry. mRNA and protein expression levels were determined for apoptosis‐related factors (e.g., Bcl‐2 and Bax), the potential target genes of miRNAs (e.g., SMAD7, SP1, and STAT3), hormone receptors (e.g., FSHR and LHR), and genes related to hormone secretion (e.g., CYP19, CYP11, and 3βHSD). The protein levels of SMAD7 were decreased in the miR‐21‐mi group but opposite to SP1 and FSHR. In the let‐7b‐mi group, Bcl‐2, SMAD7, and FSHR were suppressed but not Bax, CYP11, and 3βHSD. However, hormone secretion was not changed in the supernatant of transfected FGCs. This study provides information about ovarian miRNAs to improve the fertility in Tibetan sheep.
Heterozygous variants in the integrin subunit beta 4 gene (ITGB4) cause autosomal dominant nail dystrophy
Authors: Malovitski Kiril , Meijers Odile , Cohen-Barak Eran , Bergman James , Adir Noam , Giladi Moshe , Shalev Stavit , Sarig Ofer , Schwartz Janice , Evans Holly , Sprecher Eli , Samuelov Liat 
Published: July 2022

Abstract
STS pathogenic variants in a Dutch patient cohort clinically suspected for X-linked ichthyosis show genetic heterogeneity
Authors: Nagtzaam Ivo F. , van Leersum Frank S. , Kouwenberg Laurie C.M. , Blok Marinus J. , Vreeburg Maaike , Steijlen Peter M. , Gostyński Antoni , van Geel Michel 
Published: July 2022

Abstract
Effects of intergroup contact on explicit and implicit outgroup attitudes: A longitudinal field study with majority and minority group members
Authors: Vezzali Loris , Lolliot Simon , Trifiletti Elena , Cocco Veronica Margherita , Rae James Richard , Capozza Dora , Hewstone Miles 
Published: July 2022

AbstractA longitudinal field study tested the long‐term effects (three years) of intergroup contact on both explicit and implicit outgroup attitudes. Participants were majority (Italian) and minority (immigrant) high‐school students, who were tested at four waves from the beginning of their first year in high‐school to the end of the third school year. Results revealed, first, a longitudinal association of quantity (but not quality) of contact with lower intergroup anxiety and more positive explicit attitudes, as well as bidirectional effects over time between explicit attitudes and intergroup anxiety, on the one hand, and quantity and quality of contact, on the other. Second, reduced intergroup anxiety mediated the association between quantity of contact and improved explicit attitudes over time. Third, the product of quantity and quality of contact longitudinally predicted more positive implicit outgroup attitudes over school years. We discuss the theoretical and practical implications of findings.
Investigating the active components of Huatan Tongjing decoction for the treatment of polycystic ovary syndrome via network pharmacology
Authors: Yu Jingwei , Fu Yanhong , Zeng Lei , Zheng Yongxia 
Published: July 2022

AbstractPolycystic ovary syndrome (PCOS) is a common endocrine disease in women, potentially causing ovarian infertility for women at gestational age. Huatan Tongjing Decoction is commonly used to treat PCOS; however, the involved molecular mechanism has not been fully understood. In this study, the active components of Huatan Tongjing Decoction and potentially targeted proteins were downloaded from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. PCOS‐related genes were accessed from Malacards database. STRING database was utilized to construct a protein–protein interaction (PPI) network based on the PCOS‐related genes and the predicted targets. Subsequently, the PPI network was subjected to Random walk with restart (RWR). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed on top 50 genes with the high affinity scores to the drug targets. Subsequently, based on the predicted drug components and targets, a component–gene interaction network was constructed. Finally, the most central drug targets were selected, and the corresponding compounds were subjected to molecular docking and dynamic simulations to examine their bindings. The 122 main active components and 246 potential targets of Huatan Tongjing Decoction were obtained from TCMSP, and a total of 259 nodes and 1919 interactions were acquired from the PPI network. The top 50 genes were mainly enriched in response to peptide hormone function and PI3K‐Akt signaling pathway. Molecular docking and dynamic simulations predicted that MMP‐quercetin interaction played an important role in the treatment of PCOS using Huatan Tongjing Decoction. Luteolin and quercetin in Huatan Tongjing Decoction potentially bound MMP9 and served as active components. This study preliminarily suggested the efficacy of Huatan Tongjing Decoction against PCOS in molecular degree.
The Bucharest Early Intervention Project: Adolescent mental health and adaptation following early deprivation
Authors: Wade Mark , Parsons Jill , Humphreys Kathryn L. , McLaughlin Katie A. , Sheridan Margaret A. , Zeanah Charles H. , Nelson Charles A. , Fox Nathan A. 
Published: July 2022

AbstractOver the last 20 years, we have learned much about the extent to which early‐life deprivation affects the mental health of children and adolescents. This body of evidence comes predominantly from studies of children raised in institutional care. The Bucharest Early Intervention Project (BEIP) is the only randomized controlled trial designed to evaluate whether the transition to family‐based foster care early in development can ameliorate the long‐term impact of institutional deprivation on psychopathology during vulnerable developmental windows such as adolescence. In this review, we detail the extent to which early deprivation affects mental health during this period, the capacity of family‐based care to facilitate recovery from early deprivation, and the mechanisms underpinning these effects spanning social–emotional, cognitive, stress, and neurobiological domains. We end by discussing the implications and directions for the BEIP and other studies of youth raised in institutions.
The association of early life stress with IQ‐achievement discrepancy in children: A population‐based study
Authors: Schuurmans Isabel K. , Luik Annemarie I. , de Maat Donna A. , Hillegers Manon H. J. , Ikram M. Arfan , Cecil Charlotte A. M. 
Published: July 2022

AbstractEarly life stress (ELS) is associated with lower IQ and academic achievement; however, it remains unclear whether it additionally explains their discrepancy. In 2,401 children (54% girls, 30.2% migration background) from the population‐based study Generation R Study, latent factors of prenatal and postnatal (age 0–10) ELS were estimated, and IQ‐achievement discrepancy (age 12) was quantified as variance in academic achievement not explained by IQ. ELS was prospectively associated with larger IQ‐achievement discrepancy (βprenatal = −0.24; βpostnatal = −0.28), lower IQ (βprenatal = −0.20; βpostnatal = −0.22), and lower academic achievement (βprenatal = −0.31; βpostnatal = −0.36). Associations were stronger for latent ELS than for specific ELS domains. Results point to ELS as a potential prevention target to improve academic potential.
Heavy Tails and the Shape of Modified Numerals
Authors: Carcassi Fausto , Szymanik Jakub 
Published: July 2022

AbstractThe pattern of implicatures of the modified numeral “more than n” depends on the roundness of n. Cummins et al. (2012) present experimental evidence for the relation between roundness and implicature patterns and propose a pragmatic account of the phenomenon. More recently, Hesse and Benz (2020) present more extensive evidence showing that implicatures also depend on the magnitude of n and propose a novel explanation based on the approximate number system (Dehaene, 1999). Despite the wealth of experimental data, no formal account has yet been proposed to characterize the full posterior distribution over numbers of a listener after hearing “more than n.” We develop one such account within the Rational Speech Act framework, quantitatively reconstructing the pragmatic reasoning of a rational listener. We argue that world knowledge about the distribution of the true quantity has a substantial impact on the information conveyed by the modified numeral. We show that our pragmatic account in combination with a heavy‐tailed model of the participants' prior correctly predicts various features of the experimental data from Hesse and Benz (2020).
Utility of the IMPACT score for predicting heart transplant mortality. Analysis on a contemporary cohort of the Spanish Heart Transplant Registry
Authors: Ortiz‐Bautista Carlos , Muñiz Javier , Almenar‐Bonet Luis , Crespo‐Leiro María G. , Sobrino‐Márquez José M. , Farrero‐Torres Marta , García‐Cosio María D. , Díaz‐Molina Beatriz , Zegrí‐Reiriz Isabel , González‐Vilchez Francisco , Blázquez‐Bermejo Zorba , López Granados Amador , Gómez‐Bueno Manuel , de la Fuente‐Galán Luis , Blasco‐Peiró Teresa , Garrido‐Bravo Iris P. , García‐Romero Elena , Rábago Juan‐Aracil Gregorio , García‐Guereta Luis , Delgado‐Jiménez Juan F. 
Published: July 2022

AbstractIntroduction and objectivesThe Index for Mortality Prediction After Cardiac Transplantation (IMPACT) score was derived and validated as a predictor of mortality after heart transplantation (HT). The primary objective of this work is to externally validate the IMPACT score in a contemporary Spanish cohort.MethodsSpanish Heart Transplant Registry data were used to identify adult (>16 years) HT patients between January 2000 and December 2015. Retransplantation, multiorgan transplantation and patients in whom at least one of the variables required to calculate the IMPACT score was missing were excluded from the analysis (N = 2810).ResultsMedian value of the IMPACT score was five points (IQR: 3, 8). Overall, 1‐year survival rate was 79.1%. Kaplan‐Meier 1‐year survival rates by IMPACT score categories (0–2, 3–5, 6–9, 10–14, ≥15) were 84.4%, 81.5%, 79.3%, 77.3%, and 58.5%, respectively (Log‐Rank test:p < .001). Performance analysis showed a good calibration (Hosmer‐Lemeshow chi‐square for 1 year was 7.56;p = .47) and poor discrimination ability (AUC‐ROC .59) of the IMPACT score as a predictive model.ConclusionsIn a contemporary Spanish cohort, the IMPACT score failed to accurately predict the risk of death after HT.
Trends in marginal lung allograft survival: Advanced‐age donors improve
Authors: Miggins John James , Reul Ross Michael , Loor Gabriel , Ferreira Liam D. , Garcha Puneet S. , Goss John A. , Rana Abbas A. 
Published: July 2022

AbstractIntroductionAlthough lung demand continues to outpace supply, 75% of potential donor lungs are discarded without being transplanted in the United States. To identify the discarded cohorts best suited to alleviate the lung shortage and reduce waitlist mortality, we explored changes in survival over time for five marginal donor definitions: age >60 years, smoking history >20 pack‐years, PaO2/FiO2 < 300 mmHg, purulent bronchoscopic secretions, and chest radiograph infiltrates.MethodsOur retrospective cohort study separated 27 803 lung recipients in the UNOS Database into three 5‐year eras by transplant date: 2005–2009, 2010–2014, and 2015–2019. Multivariable Cox proportional hazards regression and Kaplan‐Meier analysis with log‐rank test were used to compare survival across the eras.ResultsThree definitions—low PaO2/FiO2, purulent bronchoscopic secretions, and abnormal chest radiographs—did not bear out as truly marginal, demonstrating lack of significantly elevated risk. Advanced donor age demonstrated considerable survival improvement (HR (95% CI): 1.47 (1.26–1.72) in 2005–2009 down to 1.14 (.97–1.35) for 2015–2019), with protective factors being recipients <60 years, moderate recipient BMI, and low Lung Allocation Score (LAS). Donors with smoking history failed to demonstrate any significant improvement (HR (95% CI): 1.09 (1.01–1.17) in 2005–2009 increasing to 1.22 (1.08–1.38) in 2015–2019).ConclusionsAdvanced donor age, previously the most significant risk factor, has improved to near‐benchmark levels, demonstrating the possibility for matching older donors to healthier non‐elderly recipients in selected circumstances. Low PaO2/FiO2, bronchoscopic secretions, and abnormal radiographs demonstrated survival on par with standard donors. Significant donor smoking history, a moderate risk factor, has failed to improve.
Exploring Monumental Architecture in Post‐independence Côte d'Ivoire: The Basilica of Our Lady of Peace in Yamoussoukro
Authors: von Reinersdorff Leonhard 
Published: July 2022

AbstractThis paper analyses the monumental architecture of post‐independence Côte d'Ivoire through the Basilica of Our Lady of Peace (1985–1989). Both the new capital project – commissioned by Côte d'Ivoire's first president Félix Houphouët‐Boigny – and the Basilica – evoking St. Peter's in Rome – represent a challenging modern heritage for Côte d'Ivoire, which in large part is not Catholic. The Basilica is virtually unknown outside of Côte d'Ivoire and is underrepresented in Western architectural histories, often portrayed in a patronizing manner. This paper aims to challenge this Western gaze. The study foregrounds power relations behind the Basilica, employing stylistic, material, constructive, social, and religious readings to produce a multi‐layered analysis of the building's history and heritage, applying discourses of modernity, post‐colonialism, and decolonisation. By analyzing international affiliations and relations, the Basilica is understood within its 20th century context and as part of the modern heritage of Africa.
Future opportunities for research in rescue treatments
Authors: Wheless James W. , Friedman Daniel , Krauss Gregory L. , Rao Vikram R. , Sperling Michael R. , Carrazana Enrique , Rabinowicz Adrian L. 
Published: July 2022

AbstractClinical studies of rescue medications for seizure clusters are limited and are designed to satisfy regulatory requirements, which may not fully consider the needs of the diverse patient population that experiences seizure clusters or utilize rescue medication. The purpose of this narrative review is to examine the factors that contribute to, or may influence the quality of, seizure cluster research with a goal of improving clinical practice. We address five areas of unmet needs and provide advice for how they could enhance future trials of seizure cluster treatments. The topics addressed in this article are: (1) unaddressed end points to pursue in future studies, (2) roles for devices to enhance rescue medication clinical development programs, (3) tools to study seizure cluster prediction and prevention, (4) the value of other designs for seizure cluster studies, and (5) unique challenges of future trial paradigms for seizure clusters. By focusing on novel end points and technologies with value to patients, caregivers, and clinicians, data obtained from future studies can benefit the diverse patient population that experiences seizure clusters, providing more effective, appropriate care as well as alleviating demands on health care resources.
Divorced parents' perceived benefits and risks of dating and sharing of dating information
Authors: Kang Youngjin , Ganong Lawrence , Ko Kwangman 
Published: July 2022

AbstractObjectiveIn this study we explored the associations among divorced parents' perceptions of the benefits and risks of dating and parents' sharing of private information about dating, specifically information related to the timing of introducing dating partners to children and coparents and disclosures to children about dating activities.BackgroundRelatively little is known about how divorced parents decide how open they should be about disclosing information about dating partners.MethodA convenience sample comprised 284 divorced mothers and 117 divorced fathers recruited following a state‐mandated divorce education program. Participants completed an online survey. Data were analyzed with regression analyses.ResultsWhen parents perceive the dating partner as a benefit in coparenting their children, they are more likely to think that dating partners should be introduced earlier to children and that more information about dating relationships should be shared with children. Concerns about other's perceptions were related to later introductions between dating partners and children.ConclusionSome of the divorced parents' perceptions of possible dating benefits and risks are related to introducing a new partner and sharing dating information with children.ImplicationsFamily practitioners could help divorced parents evaluate both how to approach introduction of dating parents, as well as dating partners' potential to assist them in childrearing if the relationship becomes serious or long term. More research is needed on what goes into parental decisions to disclose information about dating to children.