bluuebunny/crossref_metadata_2025_split huggingface dataset:
α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal
Authors: Mao Kailin , Li Xiaodan , Chen Zongde , Dong Xiaoqian , Zhangsun Dongting , Zhu Xiaopeng , Luo Sulan 
Published: February 2022

Background and Purpose: Alcohol use disorder (AUD) is a serious public health issue and affects the lives of numerous people. Previous studies have shown a link between nicotinic acetylcholine receptors (nAChR) and alcohol addiction. However, the role of α6β2* nAChR in alcohol addiction remains obscure, and whether α6β2* nAChR can be used as a potential drug target for alcohol withdrawal need to be studied.Methods: Zebrafish (Danio rerio) were exposed to 0.2% alcohol for 14 days followed by 7 days of repeated withdrawal and then retro-orbitally injected with α-conotoxin TxIB (a selective α6β2* nAChR antagonist). Open Field Test was applied to characterize zebrafish behavior parameters. The monoamine neurotransmitter amounts and their mRNA expression in the zebrafish brain were identified using ELISA and quantitative real-time PCR (RT-PCR). RNA-sequencing (RNA-seq) and subsequent bioinformatics analysis were employed to explore the potential network regulation of TxIB after alcohol withdrawal.Results: The max speed in the center area of the Open Field Test was significantly higher in the withdrawal group whereas TxIB injection corrected this abnormality. The amount and mRNA expression of monoamine neurotransmitters did not change significantly after alcohol withdrawal and TxIB administration. RNA sequencing of zebrafish brain indicated a total of 657 genes showed aberrant expression and among which 225 were reversed after TxIB injection. These reversed genes were significantly enriched in the calcium ion binding pathway and the gene expression profile was further validated by RT-PCR.Conclusion: Our finding suggests α-conotoxin TxIB improved behavioral abnormality induced by alcohol-withdrawal, and changed gene expression mainly in the calcium signaling pathway. Therefore, α-conotoxin TxIB is expected to become a potential therapeutic agent for alcohol withdrawal.
Circulating Collagen Metabolites and the Enhanced Liver Fibrosis (ELF) Score as Fibrosis Markers in Systemic Sclerosis
Authors: Chen Chen , Wang Lingbiao , Wu Jinfeng , Lu Meijuan , Yang Sen , Ye Wenjing , Guan Ming , Liang Minrui , Zou Hejian 
Published: February 2022

Background: Serum fibrosis markers for systemic sclerosis (SSc) remain limited. The Enhanced Liver Fibrosis (ELF) score is a collagen marker set consisting of procollagen type III amino terminal propeptide (PIIINP), tissue inhibitor of metalloproteinases 1 (TIMP-1), and hyaluronic acid (HA). This longitudinal study aimed to examine the performance of the ELF score and its single analytes as surrogate outcome measures of fibrosis in SSc.Methods: Eighty-five SSc patients fulfilling the 2013 ACR/EULAR criteria with the absence of chronic liver diseases were enrolled. Serum PIIINP, TIMP-1, HA, and the ELF score were measured and correlated with clinical variables including the modified Rodnan skin score (mRSS) and interstitial lung disease (ILD). Twenty SSc patients underwent a follow-up serological testing and mRSS evaluation during treatment with immunosuppressants and/or anti-fibrotic drugs.Results: Serum PIIINP, TIMP-1, and ELF score were significantly higher in patients with SSc than in healthy controls [PIIINP: 10.31 (7.83–14.10) vs. 5.61 (4.69–6.30), p &lt; .001; TIMP-1: 110.73 (66.21–192.45) vs. 61.81 (48.86–85.24), p &lt; .001; ELF: 10.34 (9.91–10.86) vs. 9.68 (9.38–9.99), p &lt; .001]. Even higher levels of PIIINP, TIMP-1, and ELF score were found in patients with diffuse cutaneous SSc than those with limited cutaneous SSc. At baseline, both PIIINP and ELF score showed good correlation with mRSS (PIIINP: r = .586, p &lt; .001; ELF: r = .482, p &lt; .001). Longitudinal analysis showed that change in PIIINP positively correlated with change in mRSS (r = 0.701, p = .001), while change in ELF score were not related, in a statistical context, to the change in mRSS (ELF: r = .140, p = .555). Serum TIMP-1 was significantly higher in SSc patients with ILD, compared to the matched group of patients without ILD [109.45 (93.05–200.09) vs. 65.50 (40.57–110.73), p = 0.007].Conclusion: In patients with SSc, the ELF score well correlates with the extent of skin fibrosis, while serum PIIINP is a sensitive marker for longitudinal changes of skin fibrosis. In the future, circulating collagen metabolites may potentially be used to evaluate therapeutic effects of anti-fibrotic treatments in the disease.
A Nomogram for Predicting Cancer-Specific Survival of Osteosarcoma and Ewing's Sarcoma in Children: A SEER Database Analysis
Authors: Wang Jinkui , Zhanghuang Chenghao , Tan Xiaojun , Mi Tao , Liu Jiayan , Jin Liming , Li Mujie , Zhang Zhaoxia , He Dawei 
Published: February 2022

BackgroundOsteosarcoma (OSC) and Ewing's sarcoma (EWS) are children's most common primary bone tumors. The purpose of the study is to develop and validate a new nomogram to predict the cancer-specific survival (CSS) of childhood OSC and EWS.MethodsThe clinicopathological information of all children with OSC and EWS from 2004 to 2018 was downloaded from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox regression analyses were used to screen children's independent risk factors for CSS. These risk factors were used to construct a nomogram to predict the CSS of children with OSC and EWS. A series of validation methods, including calibration plots, consistency index (C-index), and area under the receiver operating characteristic curve (AUC), were used to validate the accuracy and reliability of the prediction model. Decision curve analysis (DCA) was used to validate the clinical application efficacy of predictive models. All patients were divided into low- and high-risk groups based on the nomogram score. Kaplan-Meier curve and log-rank test were used to compare survival differences between the two groups.ResultsA total of 2059 children with OSC and EWS were included. All patients were randomly divided into training cohort 60% (N = 1215) and validation cohort 40% (N = 844). Univariate and multivariate analysis suggested that age, surgery, stage, primary site, tumor size, and histological type were independent risk factors. Nomograms were established based on these factors to predict 3-, 5-, and 8-years CSS of children with OSC and EWS. The calibration plots showed that the predicted value was highly consistent with the actual value. In the training cohort and validation cohort, the C-index was 0.729 (0.702–0.756) and 0.735 (0.702–0.768), respectively. The AUC of the training cohort and the validation cohort also showed similar results. The DCA showed that the nomogram had good clinical value.ConclusionWe constructed a new nomogram to predict the CSS of OSC and EWS in children. This predictive model has good accuracy and reliability and can help doctors and patients develop clinical strategies.
Educação Ambiental: uma discussão centrada na Carta da Terra e no design participativo
Authors: Aguirre Josiane Marlise Theis de , Theis Mara Rubia , Everling Marli Teresinha , Pereira Máriam Trierveiler , Xavier José Francisco Peligrino 
Published: February 2022

O desenvolvimento sustentável envolve questões socioambientais, além de conceitos de justiça, paz e ética. Este artigo tem por objetivo propor associações de conhecimentos da Educação Ambiental (EA) à área do Design e Educação, centrados nos conteúdos propostos na Carta da Terra, com relatos de experiências educacionais utilizando o design participativo no processo de ensino e aprendizagem. Os resultados revelaram que a discussão sobre a Carta da Terra e o design participativo contribuem para a expansão das ações educacionais dos coautores tanto em atividades pedagógicas quanto de pesquisa.
SIRA CETVELİNİ ŞİKÂYETİN KABULÜ KARARARLARINDA HÜKÜM SONUCUNUN OLUŞTURULMA BİÇİMİNE İLİŞKİN YARGITAY UYGULAMASININ ELEŞTİRİSİ
Authors: KARAKAŞ Cemal Fazıl 
Published: February 2022

Bu yazının konusu Yargıtay 23. (daha sonra 15 ve şimdi 6.) Hukuk Dairesinin ve Hukuk Genel Kurulunun sıra cetvelini şikâyet yargılaması sonunda verilen kabul (sıra cetvelinin iptali) kararlarının ne şekilde kaleme alınacağı konusundaki tutumunun eleştirilmesidir.
Daire ve Genel Kurul sıra cetveline şikâyetin kabulü halinde icra mahkemesinin iptal üzerine düzenlenecek sıra cetvelinin ne şekilde olacağını gerekçede belirleyerek sıra cetvelinin iptaline karar vermekle yetinmesi gerektiğini, bu ayrıntıların hüküm fıkrasında gösterilmesinin hukuka aykırı olduğunu vurgulamaktadır.
Yazıda hükmün kaleme alınışına ilişkin yasal düzenleme (HMK m.297), şikâyet yargılaması ilkeleri, icra müdürünün yetkisi, karar gerekçesinin etkisi, uyuşmazlığın giderilmesi ve eda hükmü kurulması çerçevesinde, uygulamada ortaya çıkan sorunlar da gözetilerek Dairenin ve Genel Kurulun bu tavrının yerinde olmadığı; bunun yerine hakimin iptal üzerine düzenlenecek yeni sıra cetvelinin ne şekilde olması gerektiğini kararında belirtmesinin amaca daha uygun olduğu hususu gösterilmeye çalışılmaktadır.
Application of Appropriate Technology in Integrated Coconut Processing in Lambangi Village, South Konawe, through Regional Partnership Program
Authors: Ansharullah Ansharullah , Natsir Muhammad , Taridala Sitti Aida Adha , Kasim Abdul , Herman Sriyana , Damayanti Sri 
Published: February 2022

Kelapa merupakan komoditas andalan masyarakat di Desa Lambangi, Konawe Selatan, Provinsi Sulawesi Tenggara. Namun, potensi komoditas ini belum memberikan dampak ekonomi yang nyata bagi masyarakat. Di sisi lain, dengan penerapan teknologi pengolahan kelapa secara terpadu dapat dihasilkan berbagai produk yang memiliki nilai tambah dari sisi ekonomi dan penyediaan lapangan kerja, seperti VCO, nata de coco, asap cair, dan produk kerajinan kreatif berbasis kelapa. Oleh karena itu, Program Kemitraan Wilayah (PKW) ini bertujuan untuk mengadvokasi pemerintah daerah dan masyarakat setempat untuk mewujudkan potensi ekonomi tersebut, melalui penerapan teknologi yang terintegrasi dan tepat guna. Program ini dilaksanakan dengan model peningkatan kapasitas wirausaha, alih teknologi, dan penerapan teknologi tepat guna. Hasil yang dicapai menunjukkan bahwa telah terjadi peningkatan yang signifikan dari pemerintah dan masyarakat dalam hal pengetahuan dan keterampilan dalam memanfaatkan komoditas kelapa ini. Nilai tambah ekonomi dari komoditas ini, termasuk potensi ketersediaan lapangan kerja dari komoditas ini juga meningkat signifikan. Dampak positif dari kegiatan ini adalah meningkatnya kesadaran Pemerintah Daerah, dan karenanya telah memberikan dukungan keuangan formal melalui perencanaan dan penganggaran dalam program-program mereka. Dampak positif yang diharapkan adalah mengubah kondisi Desa Lambangi menjadi desa yang mandiri secara ekonomi, sesuai dengan arahan Kawasan Perdesaan Prioritas Nasional.
Peningkatan Pengetahuan Tentang Pentingnya Keselamatan Dan Kesehatan Kerja (K3) Pada Pekerja Proyek Pembangunan Kantor Walikota Kendari
Authors: Noviati Noviati , Yasmin La Ode Muhammad , Ulva Sitti Marya , Mauliyana Andi 
Published: February 2022

Pada proyek pembangunan Kantor Walikota Kendari juga merupakan kegiatan yang kompleks melibatkan tenaga kerja, alat, dan bahan dalam jumlah besar, baik secara sendiri atau bersama-sama sehingga tingkat kecelakaan kerja pada bidang pekerjaan ini lebih besar dibandingkan bidang pekerjaan lain. Masih ada para pekerja proyek yang menyepelekan salah satu hierarki dalam pengendalian kecelakaan dan penyakit akibat kerja, yaitu masih ada yang tidak menggunakan beberapa Alat Pelindung Diri (APD), sehingga dapat diketahui bahwa pengetahuan para pekerja masih kurang terkait keselamatan dan kesehatan kerja. Pengetahuan akan suatu hal cenderung disertai dengan penerapan sikap. Tentunya hal ini berperan penting dalam mengurangi tingkat kecelakaan dan penyakit akibat kerja, sehingga diperlukan suatu program yang dapat mencegah atau mengurangi terjadinya kecelakaan kerja ataupun penyakit akibat kerja. Tujuan diadakan kegiatan pengabdian masyarakat ini adalah untuk menambah pengetahuan dan mengubah perilaku para pekerja tentang kegiatan Keselamatan dan Kesehatan kerja (K3) Hasil yang diperoleh dari kegiatan pengabdian ini adalah para pekerja telah mengetahui pentingnya Keselamatan dan Kesehatan Kerja (K3). Para pekerja juga sangat antusias mengikuti kegiatan ini karena walaupun mereka sedang dalam keadaan bekerja tetapi mereka sama sekali tidak merasa terganggu dengan kegiatan kami. Para pekerja meluangkan waktu kurang lebih 10 menit karena sosialisasi ini dilakukan face to face. Diharapkan kepada pekerja untuk tetap menaati peraturan terkait keselamatan dan kesehatan dalam bekerja, sehingga dapat tercipta suasana yang aman dalam bekerja. Dan juga kepada pimpinan terkhusus pengawas keselamatan dan kesehatan kerja (K3), jika sudah menerapkan peraturan-peraturan terkait K3, maka perlu dipadukan dengan sanksi bagi yang melanggar.
Ocorrência de oocistos de protozoários gastrointestinais em Passeriformes, Psitaciformes e Galiformes comercializadas em pet shops de Salinas, Minas Gerais
Authors: Gomes Neto Geraldo Rodrigues , Nogueira Maria Tereza Ribeiro Silva , Pereira Isabela Aquino , Vieira Vanessa Paulino da Cruz 
Published: February 2022

As parasitoses gastrointestinais, incluindo as causadas por protozoários coccídios, são doenças que podem causar alterações subclínicas ou mesmo morte de aves submetidas ao estresse, mantidas em gaiolas de alta densidade populacional. Assim, objetivou-se detectar a presença de oocistos de protozoários gastrointestinais em amostras fecais oriundas de recintos de aves das ordens Passeriformes, Psitaciformes e Galiformes comercializadas em pet shops de Salinas, Minas Gerais, Brasil. Amostras de fezes foram coletadas de 15 recintos de três espécies de Psittaciformes, duas espécies de Galiformes e uma espécie de Passeriformes. Dentre os recintos avaliados, haviam Passeriformes da espécie Serinus canaria (canário-belga), Psitaciformes das espécies Nymphicus hollandicus (calopsita), Melopsittacus undulates (periquito-australiano) e Agapornis personatus (Agapornis) e Galiformes das espécies Coturnix Coturnix japonica (codorna japonesa) e Gallus gallus domesticus (galinha doméstica). As amostras foram processadas usando a técnica de flutuação com solução saturada de cloreto de sódio (Willis-Mollay) e as amostras positivas para oocistos de protozoários coccídios foram submetidas à esporulação em dicromato de potássio 1,0% à temperatura ambiente. Ovos de helmintos não foram detectados, entretanto oocistos de protozoários foram observados em dois recintos de codorna japonesa e um recinto de canário-belga. O presente trabalho expõe a presença de coccídios de aves comercializadas no município de Salinas, no estado de Minas Gerais. O conhecimento parasitológico obtido pode contribuir para a decisão de medidas preventivas, visando a melhoria da saúde e bem-estar das aves comercializadas.
Manajemen Kesiswaan dalam Meningkatkan Kualitas Beragama Siswa MTs Unggulan Nuris Jember
Authors: Sholeh Badrus , Husnan Riayatul 
Published: February 2022

Manajemen kesiswaan memiliki peranan penting karena bertujuan untuk mengatur kegiatan-kegiatan peserta didik agar kegiatan-kegiatan tersebut menunjang proses pembelajaran di madrasah. Lebih lanjut, proses pembelajaran dapat berjalan lancar, tertib dan teratur sehingga dapat memberikan kontribusi bagi pencapaian tujuan madrasah dan tujuan pendidikan secara keseluruhan. Manajemen kesiswaan yang dimaksud adalah program-program dan kegiatan-kegiatan yang dilaksanakan oleh kesiswaan untuk meningkatkan keberagamaan peserta didik, sehingga tumbuh menjadi insan yang cerdas, terampil, beriman, bertakwa, dan berakhlak mulia. Penelitian ini difokuskan pada bagaimana manajemen kesiswaan sebagai representasi program peningkatan kualitas beragama siswa di MTs Unggulan Nuris Jember. Penelitian ini menggunakan pendekatan kualitatif deskriptif. Penelitian ini sampai pada simpulan bahwa manajemen kesiswaan sebagai representasi program peningkatan kualitas beragama siswa di MTs Unggulan Nuris Jember dimulai sejak proses penerimaan siswa baru dengan menggunakan tes keagamaan dan psikotes. Kemudian dalam proses pembinaan disiplin siswa, dilakukan sistem reward dan punishment yang melibatkan layanan-layanan pendukung di sekolah.
Kata Kunci: kualitas beragama siswa, madrasah, manajemen kesiswaan
Student management has an important role to organize students’ activities, so that these activities will support the school learning process. Furthermore, the learning process which can run smoothly, orderly and regularly can contribute to the achievement of school goals and the whole education objectives. The definition of student management in this research is the programs and activities undertaken by student affair staff to improve the students diversity, so they willl grow to be a clever, skilled, faithful, religious, and noble person. A research focus is to reveal how the student management as a representation of religious quality improvement program in MTs Unggulan Nuris Jember. This research used a descriptive qualitative approach. This research concluded that the role of student management as a representation of religious quality improvement program in MTs Unggulan Nuris Jember was started from the new students’ recruitment through religious and psychological tests. Furthermore, they applied reward and punishment system which involved the school support services to maintain the students discipline process.
Strategi Humas dalam Internalisasi Lima Nilai Budaya Kerja Kementerian Agama di PTKI Kalimantan Timur
Authors: Tamam Badrut 
Published: February 2022

Lembaga pendidikan melalui hubungan masyarakat memiliki tanggung-jawab secara moral untuk konsisten memenuhi kebutuhan masyarakat tentang informasi yang berkaitan dengan perencanaan, pelaksanaan dan evaluasinya. Melalui humas, lembaga pendidikan memperoleh pelayanan berupa corong publikasi untuk memenuhi kebutuhan masyarakat baik internal maupun eksternal. Penelitian bertujuan untuk mengetahui bagaimana strategi Humas dalam internalisasi lima nilai budaya kerja Kementerian Agama di Perguruan Tinggi Keagamaan Islam Kalimantan Timur. Jenis penelitian ini adalah kualitatif. Data diperoleh dengan teknik observasi, wawancara, dokumentasi. Hasil penelitian mengung-kapkan Humas PTKI di Kalimantan Timur, dalam membangun strategi humas guna menginternalisasikan lima nilai budaya kerja yaitu dengan memperhatikan aspek peranan dan tugas humas yakni, expert preciber, Problem solving facilitator, communicator facilitator, technican communication. Peranan humas sebagaimana tertuang dalam teori yang dikemukakan Criss Skinner tersebut menjadi formulasi bagi praktisi humas dalam membangun strategi dan internalisasi lima nilai budaya kerja yaitu integritas, profesionalitas, inovasi, tanggungjawab dan keteladanan secara inklusif.
Kata kunci: Humas, PTKI, lima budaya kerja, Kementerian Agama

Educational institution through public relations (PR) has a moral responsibility to consistently meet society's needs on the information relating to its planning, execution and evaluation. Through public relations, educational institution receives services in the form of public publicity to meet both internal and external needs. The research aimed to find out how a PR strategy in the internalization of the five cultural values works of the Ministry of Religious Affairs at East Kalimantan Religious College. This type of research was qualitative. Data obtained through observation techniques, interviews, and documentations. The research suggests that PTKI's public-relations in East Kalimantan, in building a PR strategy for internalizing the five cultural values of the working culture, expert preciber, the interest-facilitator problem, communicator/com-municator, technically communication techniques. The role of public relations as brought about by the criss skinner theory has become a formulation for public-relations practitioners in building a strategy and the internalization of the five cultural values of integrity, professionality, innovation, responsibility and individuality.
Pelatihan Pengolahan Sampah Botol Kaca dengan Teknik Decoupage di Desa Cibitung Wetan, Kabupaten Bogor
Authors: Andriana Yunita Fitra , Nurrul Haq Bayyinah , Septiana Ulfa 
Published: January 2022

This community service activity, which was carried out in Desa Cibitung Wetan, Kabupaten Bogor, aims to increase the skills of housewives in processing glass bottles waste into flower vases. The Posdaya in that village has a waste bank program that has been running well. One of the programs carried out routinely at the waste bank is sorting unorganic waste that can be recycled. Even so, after this sorting process a series of further processing is needed. The method used in this activity is a short training by providing special skill, which is decoupage technique. The training started with giving demonstrations, then continued with hands-on practice and ended with discussion session. Participants in this training activity consisted of housewives who were members of Posdaya. They come from families with middle to lower economic backgrounds. The skills given in this training are expected to increase the creativity of the participants in processing waste into products with selling value, so as it is able to increase family income.
Keywords: Waste Processing, Selling Value Products
EKSTRAKSI ASAM OKSALAT DARI SEKAM PADI UNTUK AGEN PEREDUKSI ION CR(VI)
Authors: Dyah Ayu Pitaloka Putri , Ridho Rosyid , Endara Safitri Rika 
Published: January 2022

Pengaruh katalis asam oksalat dari sekam padi terhadap efektivitas fotoreduksi ion Cr(VI) telah diteliti. Proses fotoreduksi ion Cr(VI) dilakukan dalam suatu sistem reaktor tertutup (sistem batch) yang dilengkapi dengan lampu UV. Dalam penelitian ini dipelajari pengaruh konsentrasi NaOH dan CaCl2 pada sintesis asam oksalat dari sekam padi dan pengaruh massa asam oksalat dan sinar UV terhadap efektivitas fotoreduksi ion Cr(VI).
Hasil penelitian ini menunjukkan bahwa konsentrasi NaOH dan CaCl2 mempengaruhi hasil dari massa asam oksalat, untuk konsentrasi NaOH hasil massa optimum sebesar 0,7686 g dengan konsentrasi NaOH sebesar 2,5 M dan untuk konsentrasi CaCl2 hasil massa optimum sebesar 0,7905 g dengan konsentrasi CaCl2 sebesar 1 M. Pengaruh massa asam oksalat dapat meningkatkan hasil fotoreduksi ion Cr(VI) yaitu massa optimum 30 mg hasil fotoreduksi sebesar 97,74 %. Sedangkan untuk efektivitas fotoreduksi ion Cr(VI) lebih bagus menggunakan sinar UV pada proses fotoreduksinya dengan hasil sebesar 97,74 % dibandingkan tanpa menggunakan sinar UV dengan hasil 66,84%
Self-Management pada Anak Epilepsi Menggunakan Mobile Health Application: Literature Review
Authors: Irdelia Indah Putri , Putri Nila Sari  
Published: February 2022

Latarbelakang: Penyakit kronis neurologis pada anak yang sering ditemukan yaitu epilepsi. Sehingga dibutuhkan sebuah teknologi yang dapat mempermudah penderita epilepsi untuk melakukan self-management. Teknologi yang dapat diterapkan seperti pada pengobatan epilepsi yaitu mobile health application yang digunakan untuk melakukan self-management. Tujuan: untuk mendeskripsikan penggunaan mobile health application untuk self-management pada anak epilepsi. Metode: Penelitian ini menggunakan metode Literarature review dari online database UI: Scopus, EBSCOhost, ProQuest, dan Science Direct (2016-2020) dengan menggunakan kata kunci mobile application, mobile health application, self-management, epilepsy. Hasil: Hasil pencarian di dapatkan 10 artikel yang dipilih untuk dilakukan telaah dan didapatkan bahwa mobile health application membantu self-management pada anak epilepsi serta meningkatkan kepatuhan pengobatan epilepsi dan membantu penanganan kejang pada anak. Kesimpulan: Mobile health application memberikan manfaat bagi anak epilepsi dalam melakukan self-management.