bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning-based prediction of critical illness in children visiting the emergency department
Authors: Hwang Soyun , Lee Bongjin 
Published: February 2022

Objectives
Triage is an essential emergency department (ED) process designed to provide timely management depending on acuity and severity; however, the process may be inconsistent with clinical and hospitalization outcomes. Therefore, studies have attempted to augment this process with machine learning models, showing advantages in predicting critical conditions and hospitalization outcomes. The aim of this study was to utilize nationwide registry data to develop a machine learning-based classification model to predict the clinical course of pediatric ED visits.

Methods
This cross-sectional observational study used data from the National Emergency Department Information System on emergency visits of children under 15 years of age from January 1, 2016, to December 31, 2017. The primary and secondary outcomes were to identify critically ill children and predict hospitalization from triage data, respectively. We developed and tested a random forest model with the under sampled dataset and validated the model using the entire dataset. We compared the model’s performance with that of the conventional triage system.

Results
A total of 2,621,710 children were eligible for the analysis and included 12,951 (0.5%) critical outcomes and 303,808 (11.6%) hospitalizations. After validation, the area under the receiver operating characteristic curve was 0.991 (95% confidence interval [CI] 0.991–0.992) for critical outcomes and 0.943 (95% CI 0.943–0.944) for hospitalization, which were higher than those of the conventional triage system.

Conclusions
The machine learning-based model using structured triage data from a nationwide database can effectively predict critical illness and hospitalizations among children visiting the ED.
PENERAPAN GOOD MANUFACTURING PRACTICE (GMP) DAN SANITASION STANDARD OPERATION PROCEDURES (SSOP) PADA PENGOLAHAN UDANG VANNAMEI (Litopenaeus vannamei) KUPAS MENTAH BEKU Peeled Deveined (PD)
Authors: Hafina Abrar , Sipahutar Yuliati H , Siregar Arpan N 
Published: February 2022

Udang vanamei (Litopenaeus vannamei) merupakan salah satu produk perikanan yang mempunyai nilai ekonomis penting. Produk ini memiliki faktor penentu sebagai komoditas ekspor dalam perdagangan internasional. Untuk itu, diperlukan proses penanganan yang baik di Indonesia. Penelitian ini bertujuan untuk mengetahui penerapan GMP dan SSOP pada proses pengolahan udang kupas mentah beku (peeled deveined). Metode dilakukan dengan observasi dan survei, dengan mengikuti secara langsung seluruh proses penerapan persyaratan kelayakan dasar (GMP, SSOP), mulai dari penerimaan bahan baku hingga pemuatan, dengan melakukan pengujian terhadap mutu (organoleptik, mikrobiologi, antibiotik), pengamatan penerapan rantai dingin, rendemen, dan produktivitas tenaga kerja. Analisa data dilakukan dengan deskriptif. Hasil penelitian menunjukkan bahwa penerapan kelayakan dasar GMP dan SSOP sudah dilakukan dengan baik sesuai SNI No. 3457-2014 tentang udang kupas mentah beku. Hasil pengujian mutu organoleptik bahan baku dan produk akhir adalah 8, uji mikrobiologi berkisar 9 x 103 kol/gr - 2,5 x 103 kol/gr dan not detected untuk hasil uji antibiotik, sesuai dengan SNI. Penerapan rantai dingin telah dilakukan dengan baik dengan suhu udang bahan baku 3º C. Rendemen pada potong kepala dengan dan pengupasan kulit rata-rata 69,8 % dan 81,1 % sesuai dengan standar perusahaan. Produktivitas pada proses pemotongan kepala dan pengupasan adalah 37,1 dan 7,75 kg/jam/orang, sesuai dengan standar perusahaan.
Analisis Hadis Pelestarian Lingkungan Hidup
Authors: Salsabila Saila 
Published: February 2022

Tujuan penelitian ini membahas penjelasan hadis tentang pelestarian lingkungan. Metode penelitian ini menggunakan metode kualitatif melalui studi pustaka dengan analisis isi. Dalam pembahasan penelitian ini meliputi pandangan umum tentang lingkungan, hadis tentang melestarikan lingkungan, dan upaya pelestarian lingkungan. Penelitian ini menyimpulkan bahwa melestarikan lingkungan merupakan hal yang penting bagi manusia sebagai makhluk sosial dan merupakan salah satu bentuk keberimanan terhadap Allah SWT. Penelitian ini diharapkan memiliki manfaat bagi pengayaan khazanah pengetahuan Islam.
Kata kunci: Hadis; lingkungan; makhluk hidup; manusia.
The Effect of Perioperative Biologic Disease-Modifying Anti-Rheumatic Drugs on the Risk of Postoperative Complications
Authors: van Duren Bernard H. , Wignall Alice , Goodman Susan , Hewitt Catherine , Mankia Kulveer , Pandit Hemant 
Published: February 2022

Background:
Biologic disease-modifying anti-rheumatic drugs (bDMARDs) are effective in treating inflammatory diseases and have been increasingly utilized over the past decade. Patients who receive bDMARDs have been shown to be at an increased risk for surgical site infection following surgical procedures. The severe consequences of infection following orthopaedic surgery have led to the practice of withholding bDMARDs perioperatively; however, there has been no definitive evidence showing a clear benefit of withholding the use of bDMARDs, and in doing so, patients may be at an increased risk for higher disease activity. As such, the purpose of the present study was to compare the risk of infection, delayed wound healing, and disease flares associated with the use of bDMARDs in patients undergoing orthopaedic surgical procedures.

Methods:
We performed a systematic literature search of MEDLINE, Embase, and PubMed CENTRAL databases for studies comparing continuing and withholding the use of bDMARDs in patients undergoing orthopaedic procedures. Inclusion criteria were established following the PICO (Population, Intervention, Comparison, and Outcomes) approach: Population = patients who underwent orthopaedic surgical procedures and who were taking bDMARDs. Intervention = withholding the use of bDMARDs. Comparator = continuing the use of bDMARDs. Outcomes = surgical site infection, delayed wound healing, and disease flares. Article titles and abstracts were screened prior to review of the full text. Overall odds ratios (ORs) and associated 95% confidence intervals (CIs) for pooled effects were calculated.

Results:
Eleven studies met the inclusion criteria, providing data for 7,344 patients, including 2,385 patients who continued and 4,959 who withheld their bDMARDs perioperatively. Continuing bDMARDs was associated with a significantly lower risk of disease flares (OR, 0.22; 95% CI, 0.05 to 0.95; p = 0.04) and nonsignificant increases in surgical site infections (OR, 1.11; 95% CI, 0.82 to 1.49; p = 0.49) and wound complications (OR, 2.16; 95% CI, 0.48 to 9.85; p = 0.32).

Conclusions:
The present systematic review highlights the limited evidence supporting the current practice of stopping bDMARDs perioperatively. These findings suggest that patients may not be at an increased risk for developing infection or wound complications if bDMARDs are continued but are at an increased risk for disease flare if bDMARDs are withheld. However, our conclusions are limited by the retrospective and heterogenous nature of the data, and possibly by a lack of study power.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Strain Partitioning along Terrane Bounding and Intraterrane Shear Zones: Constraints from a Long-Lived Transpressional System in West Gondwana (Ribeira Belt, Brazil)
Authors: Faleiros F. M. , Ribeiro B. V. , Campanha G. A. C. , Cawood P. A. , Cabrita D. I. G. , Yogi M. T. A. G. , Milani L. A. , Lemos-Santos D. V. , Almeida V. V. , Rodrigues S. W. O. , Malta I. S. , Forero-Ortega A. J. 
Published: February 2022

Abstract
Shear zones are zones of localized high strain accommodating differential motion in the lithosphere and impacting the crustal rheology and deformational history of orogenic belts. Although terrane bounding shear zones are widely studied, intraterrane shear zones and their tectonic significance, especially in association with supercontinent assembly, is a largely unexplored topic. The Ribeira Belt (SE Brazil), a Neoproterozoic-Cambrian orogenic belt from West Gondwana, is dissected by a crustal-scale NE-trending transcurrent shear zone system that juxtaposes composite terranes. Despite its extensive coverage and complexity, this shear zone system remains poorly investigated. In this paper, we explore the thermal and deformational regimes, and timing of ductile shearing using a multiscale approach combining structural analysis derived from remote sensing and field-based structural data, microstructures, quantitative structural analysis, and multimineral U–Pb geochronology (zircon, titanite, monazite, and xenotime). Our data, combined with previously published data, indicate a transitional northeastward increase in metamorphic conditions from lower greenschist to granulite facies conditions (from 250–300 to 750–800°C), reflecting the different crustal levels that are exposed. Vorticity and finite strain data indicate a complex strain regime with varied contributions of pure and simple shear and oblate-shape ellipsoids in strike-slip shear zones and prolate-shaped ellipsoids in dip-slip reverse shear zones. The strain set suggests that all shear zones were developed under subsimple shear deformational regimes involving thrusting and folding followed by wrench tectonics. The pure shear component of deformation was accommodated in folded domains between shear zones. Geochronological data suggest intermittent ductile shear zone activations from ca. 900–830 to 530 Ma, partially coeval with at least two major episodes of terrane accretion at 850–760 Ma and 610–585 Ma. The spatial and temporal record of shear zones within the Ribeira Belt indicates that some relate to assembly of the belt and represent either terrane bounding structures (e.g., Itapirapuã shear zone) or intraterrane structures (e.g., Ribeira, Figueira, and Agudos Grandes shear zones), whereas others are terrane bounding, postcollisional shear zones (e.g., Taxaquara shear zone) reactivated in an intracontinental setting (560–535 Ma).
Isytiqâq Dalam Bingkai Ilmu Fiqhul Lughah dan Pendapat Para Ulama
Authors: Fatoni Ahmad Sirfi 
Published: February 2022

This article examines isytiqâq within the framework of Fiqhul lughah and the opinion of scholars. Isytiqâq is important to be studied more deeply because it is one of characteristic of Arabic language and within it we can produce new vocabulary words that have never been found before. The impact is that Arabic language is getting richer and more dynamic. The research method used is descriptive-critical analysis. The data collection technique uses the observation method with the note. The findings obtained are: (1) there are three kinds of isytiqâq: a) Al-isytiqâq al-shaghir, b) Al-isytiqâq al-Kabir, c) Al-isytiqâq al-Akbar, (2) Arab scholars differed on the issue of the origin of isytiqâq and its scope. Some scholars argue that some words are musytaq and some aren’t musytaq. Meanwhile, other scholars argue that all words are musytaq. While some others suspect that all words are authentic, there are no words that are musytaq from other words; (3) The scholars who think that some words are musytaq and some aren’t musytaq are the opinions of scholars of Bashrah and Kufah. The scholars of Bashrah argue that mashdar is the origin of isytiqâq. Meanwhile, scholars of Kufah argue that fi’il is the origin of isytiqâq; (4) The relationship between language and isytiqâq has a reciprocal relationship.
Pengembangan Buku Ajar Bahasa Arab Berbasis pada Nilai-Nilai Islam-Indonesia di IAIN Salatiga
Authors: Habibi Burhan Yusuf , Putri Wakhidati Nurrohmah 
Published: February 2022

This study aims to develop Arabic language teaching materials 1 based on Islamic-Indonesian values ​​at the State Islamic Institute of Slaatiga. This research is motivated by the lack of specific teaching materials for this course after transferring status from STAIN to IAIN and learning Arabic was returned to the faculty. This research is a type of research and development with the Borg & Gall development model. The analysis technique in this study uses quantitative descriptive techniques. The results showed that the results of student responses to the Arabic Textbook 1 Based on Islamic-Indonesian Values ​​at the Salatiga State Islamic Institute which was developed viewed from the learning aspect obtained an average score of 4.025, the content or material aspect with an average score average 4.095, aspects of the display with an average score of 4.098 and aspects of the presentation with an average score of 4.08, then the overall average score is 4.075. Thus, Arabic textbook based on Islamic-Indonesian values ​​is worthy of being used as teaching material in the Arabic language course 1 at the Salatiga State Islamic Institute.
Kalimat Kondisional dalam Bahasa Arab dan Bahasa Inggris (Analisis Kontrastif Bentuk dan Fungsi)
Authors: Yusuf Muhammad , Bahraen Muhammad Jauzil 
Published: February 2022

Conditional sentences are part of the syntactic system that exists in Arabic and English. In general, the provisions relating to conditional sentences in the two languages ​​have similarities and differences. This study seeks to identify more deeply related to this matter by way of contrasting it. The subject matter relates to the similarities and differences in the form and function of conditional sentences in Arabic and English. This study is a literary style that optimizes related literature to discuss the object of research. This study formulates that the similarity in the form and function of conditional sentences in Arabic and English, namely: it can be stated implicitly, has two-sentence forms, has clear rules, has the same primary components, can be used to convey open and conjectural conditions. The differences are: Arabic markers are more varied, the characteristics of conditional sentences in Arabic focus on the markers while in English it is more on tenses, the construction of conditional sentences in Arabic is more varied than in English
Abstrak
Kalimat kondisional merupakan bagian dari sistem sintaksis yang ada dalam bahasa Arab dan bahasa Inggris. Lazimnya, ketentuan yang berkaitan dengan kalimat kondisional dalam kedua bahasa tersebut terdapat persamaan dan perbedaan. Penelitian ini berupaya untuk mengidentifikasi lebih dalam berkaitan dengan hal tersebut dengan cara mengkontraskannya. Adapun pokok masalah berkaitan dengan persamaan dan perbedaan bentuk dan fungsi kalimat kondisional dalam bahasa Arab dan bahasa Inggris. Kajian ini bercorak kepustakaan yang mengoptimalkan literatur terkait untuk membahas objek penelitian. Kajian ini merumuskan bahwa persamaan bentuk dan fungsi kalimat kondisional dalam bahasa Arab dan bahasa Inggris yaitu: dapat dinyatakan secara implisit, mempunyai dua bentuk kalimat, mempunyai aturan yang jelas, mempunyai komponen primer yang sama dan dapat digunakan untuk menyampaikan kondisi yang bersifat terbuka dan dugaan. Adapun perbedaannya adalah: penanda bahasa Arab lebih variatif, karakteristik kalimat kondisional dalam bahasa Arab menitikberatkan pada penanda sementara dalam bahasa Inggris lebih kepada tenses, kontruksi kalimat kondisional dalam bahasa Arab lebih variatif dari bahasa Inggris
Tren Sastra Eropa dan Keterpengaruhannya Terhadap Sastra Arab (Kajian Sastra Banding)
Authors: J.P Angga Mustaka 
Published: February 2022

ABSTRACTTrends in European Literature and its influence on Arabic Literature, comparative literary studies. The background of this article departs from the many literary schools in Europe that have an influence on Arabic literature. The research method used is a qualitative method. The data collection technique used is the collection of documents or documentation. The data analysis technique in this article uses the Creswell model of qualitative data analysis. The approach used in this research is the historical approach. The results of this research are; 1) The literature that pioneered the birth of comparative literary studies, namely is French literature. 2) American literature emerged as a response to French literature. 3) The influence of European literature on Arabic literature can be seen from the characteristics of European poets who are very oriented to the rules and styles of Arabic literature. 4) The influence between European literature and Arabic literature was also caused by the many Arab writers who migrated to Europe for various reasons.
Abstrak
Artikel ini bertujuan untuk membahas tren Sastra Eropa serta keterpengaruhannya terhadap Sastra Arab, kajian sastra banding. Adapun latar belakang dari artikel ini berangkat dari banyaknya madzhab-madzhab sastra di Eropa yang mempunyai keterpengaruhan terhadap Sastra Arab. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan historis. Teknik pengumpulan data yang digunakan adalah pengumpulan dokumen atau dokumentasi. Teknik analisa data pada artikel ini menggunakan analisa data kualitatif model Creswell. Hasil penelitian ini adalah; 1) Sastra yang mempelopori lahirnya kajian sastra banding yaitu adalah sastra Perancis.2) Sastra Amerika muncul sebagai respon dari Sastra Perancis. 3) Keterpengaruhan Sastra Eropa terhadap Sastra Arab terlihat dari ciri khas para penyair Eropa yang sangat berorientasi pada kaidah-kaidah dan gaya Sastra Arab. 4) Keterpengaruhan antara Sastra Eropa dan Sastra Arab juga disebabkan akibat banyaknya sastrawan Arab yang hijrah ke Eropa dengan berbagai alasan
Heavy Oil Recovery by Alkaline-Cosolvent-Polymer Flood: A Multiscale Research Using Micromodels and Computed Tomography Imaging
Authors: Su Hang , Zhou Fujian , Zheng Ao , Wang Lida , Wang Chuan , Yu Fuwei , Kang Lixia , Li Junjian 
Published: February 2022

Summary
For reservoirs containing oil with a high total acid number, the alkali-cosolvent-polymer (ACP) flood can promote the formation of microemulsion rather than viscous macroemulsion and achieve good mobility control. The enhanced oil recovery (EOR) performance of ACP flood has been studied at core and reservoir scale in detail; however, the effect of ACP flood on residual oil still lacks enough research. In this paper, a micromodel with a single channel is used to clarify the dynamic effects of alkali-cosolvent (AC) and ACP solutions on the residual oil after waterflood. Based on this, medical computed tomography (Medical-CT) scan and microcomputed tomography (Micro-CT) scan are used in combination to visualize microscale flow and reveal the mechanisms of residual oil reduction during ACP flood. The heterogeneous core plugs containing two layers of different permeabilities are used for coreflood experiments to clarify the EOR performance of ACP flood in heterogeneous reservoirs. The oil saturation is monitored by Medical-CT. Then, two core samples are drilled in each core plug that is used in the coreflood experiment. The decrease of residual oil saturation caused by ACP flood is further quantified by Micro-CT imaging. Results show that ACP flood is 14.5% oil recovery higher than AC flood (68.9%) in relative high permeability layers (HPLs) and 17.9% higher than AC flood (26.3%) in relative low permeability layers (LPLs). Compared with AC flood, ACP flood shows a more uniform displacement front, which implies that the injected polymer effectively weakened the viscosity fingering. This is similar to the experimental results demonstrated visually in the micromodel experiments. ACP solution first generates an oil bank by the mobility ratio improvement to mobilize residual oil and then dissolve and emulsify residual oil under ultralow interfacial tension (IFT) conditions. Moreover, a method that can calculate the ratio of oil/water distribution in each pore is developed to establish the relationship between the residual oil saturation of each pore and its pore size, and concluded that they follow the power-law correlation.
Safety and Efficacy of a Cardiovascular Polypill in People at High and Very High Risk without a Previous Cardiovascular Event The International VULCANO Randomised Clinical Trial
Authors: Mostaza Jose María , Suárez-Fernández Carmen , Cosín-Sales Juan , Gómez-Huelgas Ricardo , Brotons Carlos , Araujo Francisco Pestana , Borrayo Gabriela , Ruiz Emilio 
Published: February 2022

Abstract
BackgroundCardiovascular (CV) polypills are a useful baseline treatment to prevent CV diseases by combining different drug classes in a single pill to simultaneously target more than one risk factor. The aim of the present was to determine whether the treatment with the CNIC-polypill was at least non-inferior to usual care in terms of low-density lipoprotein cholesterol (LDL-c) and systolic BP (SBP) values in subjects at high or very high risk without a previous CV event. MethodsThe VULCANO was an open-label trial involving 492 participants randomised to the CNIC-polypill or usual care. The primary outcome was the mean change in LDL-c and SBP values after 16 weeks of treatment. ResultsThe upper confidence limit of the mean change in LDL-c between treatments was below the prespecified margin of 10 mg/dL and above zero, and non-inferiority and superiority of the CNIC-polypill (p =0.0001) was reached. There were no significant differences in SBP between groups. However, the upper confidence limit crossed the prespecified non-inferiority margin of 3 mm Hg. Significant differences favoured the CNIC-polypill in reducing total cholesterol (p =0.0004) and non-high-density lipoprotein cholesterol levels (p =0.0017). There were no reports of major bleeding episodes. The frequency of non-serious gastrointestinal disorders was more frequent in the CNIC-polypill arm.ConclusionThe switch from conventional treatment to the CNIC-polypill approach in patients at high CV risk without a previous event was safe and appears a reasonable strategy to control risk factors and prevent CVD.
The Epidemiological Trend of Esophageal Cancer in Mumbai, India, Over the Past Fifteen Years
Authors: Sekar Anbarasan , Noronha Vanita , Rajendra Akhil , Mokal Smruti , Patil Vijay , Menon Nandini , Chopade Sunil , Singh Ajay Kumar , Kaushal Rajiv kumar , Mahajan Abhishek , Janu Amit , Purandare Nilendu , Dikshit Rajesh , Banavali Shripad , Prabhash Kumar , Badwe Rajendra 
Published: February 2022

Abstract
Background:
There has been a definite change in the histopathological spectrum of esophageal cancer towards adenocarcinoma seen in developed countries. In India such studies were limited.
Materials and Methods:
We retrospectively evaluated patients with histologically proven esophageal cancer who were registered at the Tata Memorial Hospital (Mumbai, India) between 2003 and 2018. The primary aim was to analyze the time-trend of the histological pattern of esophageal cancer. Our secondary objectives included evaluating whether there was any correlation between age, sex, demographics, socioeconomic status, the presence of comorbidities and substance abuse and the histological type of esophageal cancer.
Results:
Among 7874 patients with esophageal cancer, 5092 (64.7%) were men, with M:F of 2.5:1. The median age was 57 years (IQR, 50-65); Of the 4912 patients in whom a history of tobacco or alcohol use had been elicited, 1360 (27.7%) patients denied substance abuse. Majority of tumor was in middle-third 2942 (41.5%). Squamous cell carcinoma was the histological type in 6413 (81.4%) patients. Multivariate analysis showed that female sex and substance abuse were positively associated with squamous cell carcinoma, while the presence of comorbidities and location of the primary in lower esophagus/GEJ were positively associated with adenocarcinoma.
Conclusions:
There is no evidence of an epidemiologic shift in the histopathologic spectrum of esophageal cancer in India over last two decades. Four out of five Indian patients with esophageal cancer have squamous cell histology. This is important to recognize, given the varying molecular spectrum and efficacy of therapeutic modalities based on histopathology.