bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular mechanism and effects of urocortin II on rat adventitial fibroblast calcification induced by calcified medium
Authors: Zhang Xusheng , Huang Zhanjun , Fan Xiaorong , Tan Xiaoqing , Lu Chengzhi , Yang Jianshe 
Published: March 2022

Abstract

The present study aimed to assess the role of urocortin II (UII) in the process of vascular calcification in vitro by using a calcification model, and to detect the changes in the mRNA and protein levels of associated markers in rat adventitial fibroblasts (AFs) during their phenotypic transformation to osteoblast cells, and clarify the main signal transduction pathway of UII responsible for regulating vascular calcification and AF phenotypic transformation of osteoblast cells and prove that UII was an endogenous factor promoting vascular calcification, so as to provide an effective experimental basis for the clinical regulation of related diseases caused by vascular calcification. Finally we successfully constructed the calcified cell model, found that UII was an endogenous substance regulating vascular calcification, regulated the vascular calcification by promoting apoptosis and inhibiting autophagy through up- and down-regulated Bax and Bcl-2/Beclin-1 level, and the Wnt/β-catenin signaling pathway was involved.
Cancer associated fibroblasts (CAFs) derived exosomes with A promoted liver metastasis of pancreatic cancer by regulating C through transcription factor B
Authors: Tan Guang , Lin Zhikun , Luo Haifeng , Ning Zhen , Ma Chi , Du Jian 
Published: March 2022

Abstract
Cancer-associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic ductal adenocarcinomas (PDACs). Despite the long-standing recognition of the prominence of CAFs in PDAC, the effect of extracellular vesicles derived from CAFs on the liver metastasis of PDACs cells is not well characterized. The aim of this study was to determine whether specific derived from CAFs might be involved in liver metastasis in PDACs. We found that CAFs are intrinsically related with liver metastasis and thus the potential role of CAFs in PDACs was highlighted. Further, CAFs significantly increase the release of extracellular vesicles wit A and it caused increased liver metastasis. Advanced experiments demonstrated that, C, in recipient epithelial cells and promote proliferation, was up-regulated by A in EVs from CAFs. Besides, treatment of an inhibitor of A as well as an inhibitor of exosome release, GW4869, significantly reduces the activation of B, thus decreased the activity of C. Collectively, these findings show the potential for exosome inhibitors as treatment options for overcoming PDAC liver metastasis.
Acid-activated bentonite blended with sugarcane bagasse ash as low-cost adsorbents for removal of reactive red 198 dyes
Authors: Adane Teshale , Hailegiorgis Sintayehu Mekuria , Alemayehu Esayas 
Published: March 2022

Abstract
The present research work investigated the removal efficiency of acid-activated bentonite blended with a sugarcane bagasse ash (SCBA) adsorbent for the removal of reactive red 198 (RR198) from a synthetic dye solution. The effect of the adsorption parameters of bentonite on SCBA blending ratio, dye solution pH, adsorption contact, adsorbent dosage, and initial dye concentration was investigated, and the parameters were optimized for maximum RR198 removal from the synthetic dye solution. At an optimum condition of 1:1 bentonite to the SCBA blending ratio, a solution pH of 2, 3.7 g/L of adsorbent dosage, and 15 mg/L of initial dye concentration 150 min of adsorption time, the properties of adsorbents such as adsorbent specific surface area, crystalline phase structure, functional groups, and surface morphologies of the adsorbents were investigated. At optimum conditions, 97% RR198 removal efficiency of the adsorbent was achieved. In order to determine adsorption kinetics and isotherm models, different adsorption models were employed. It was observed that the adsorption of the RR198 dye into the acid-activated bentonite blended with the SCBA adsorbent was represented well by the Langmuir isotherm model and the adsorption kinetics order was found to be the pseudo-second order.
The Effect of Additional Childcare Roles on COVID-19 Symptom Knowledge Among Youth in South Africa
Authors: De Wet-Billings Nicole , Anyanzu Francis 
Published: March 2022

Background:
As of March 2020, young people performed additional household responsibilities due to COVID-19 in South Africa. In particular, youth assisted with childcare since schools were closed. However, little is known of the impact of changing roles and additional responsibilities on young people’s ability to keep abreast of important information regarding the spread of the virus.

Objective:
The aim of the study was to determine the relationship between additional childcare responsibilities and complete awareness of the knowledge of symptoms of COVID-19 among young people in South Africa.

Methods:
Using data from the South African National Income Dynamics CRAM Survey (wave 1), 710 (72.08%) young individuals (18-24 years old) who listed symptoms of COVID-19 were analysed. The study controlled for covariates as additional childcare responsibilities, demographic and socioeconomic characteristics of the respondents. Cross-tabulations and a binary logistic regression model were used to determine the relationship between covariates and the outcome of the knowledge of symptoms.

Results:
None of the respondents reported 100% knowledge of the symptoms of COVID-19 while 57.5% reported having additional childcare responsibilities. Among youth with additional childcare, 90.71% knew regarding approximately half (50%) of the symptoms. Finally, not having additional childcare roles increased the odds of knowing at least three symptoms of the coronavirus (OR= 2.36; CI: 1.227387 - 2.543323).

Conclusion:
Youth, especially those spending increasing time caring for children, need more access to information regarding the virus. This information is key to protecting themselves and the children in their care.
Tres experiencias de educación comunitaria del patrimonio cultural
Authors: Guerrero García Juan José 
Published: March 2022

El campo científico del patrimonio cultural tiene una responsabilidad inherente frente a la sociedad que es sujeto-objeto de estudio, además de financiadora de las actividades académicas. Los conocimientos deben regresar mediante experiencias educativas a quienes han producido la verdadera “cultura”.
La educación comunitaria del patrimonio cultural requiere del conocimiento de los pueblos, del manejo de los contenidos académicos y de un gran esfuerzo creativo que logre armonizar tiempos, recursos, saberes artísticos, científicos y artesanales. Sin embargo, nada es tan necesario como tener la firme intención de comunicarse con el otro.
En la presente charla trataremos sobre tres experiencias de educación comunitaria del patrimonio cultural: Proyecto INAH comunidad dirigido por Jaime Delgado (Zona Arqueológica de Teotihuacán), “La peregrinación de los tamemes en Tlatelolco” con el grupo Titereliches (CCU-Tlatelolco), y “El saber de las montañas” C.B.C San Juan Tlacoténco, Morelos.
Roberto Campos Velázquez. Sonidos símbolo. Una etnografía del calendario ceremonial de los huaves de San Mateo del Mar.
Authors: Avilés Velazquez Víctor Manuel 
Published: March 2022

De todos los sonidos por los que deambulamos día a día solo algunos sobresalen del marco de lo cotidiano. Entre el ruido de coches, el murmullo de la calle y el estruendoso desliz de los transeúntes surge de pronto un sonido inusual: alguna marcha civil, un trovador de mercado, la música de alguna fiesta o cualquier otro que llama nuestra atención y del cual percibimos significados.
Estos ambientes sonoros cumplen funciones específicas dentro de las sociedades. Un ejemplo de ello, es el que el Mtro. Roberto Campos Velázquez expone sobre la comunidad huave de San Mateo del Mar, ubicada en la costa de Oaxaca. Su objeto de estudio dentro de esta comunidad está en la celebración de tres fiestas pertenecientes a su calendario ritual, dedicadas a San Mateo Apóstol, a la Virgen de la Candelaria y al Corpus Cristi. En ellas se desarrollan diversos niveles sonoros y rituales concretamente divididos y clasificados por el autor en tres categorías: expresiones localmente concebidas como musicales: canciones y piezas rituales; señales audibles concebidas como no musicales, ya sean toques de campanas, matracas, clarines, pirotecnia u otros; y por último, expresiones verbales: discursos o parlamentos y vocalizaciones onomatopéyicas.
Uno de los objetivos principales buscado por Roberto luego de analizar estos hechos sonoros es mostrar el conocimiento social, histórico y mítico que los huaves poseen y transmiten a través de todos los campos sonoros en cada celebración, pues, citando sus palabras: “Las fiestas y las ceremonias huaves ofrecen esos contextos sociales de producción y escucha en los que se pregunta y se aprende”.
Como complemento, no bastando el papel y la letra, para que el lector comprenda cabalmente su estudio, Roberto Campos incluye en su libro una tarjeta USB, en la cual se encuentran los materiales sonoros y visuales que abarcan: piezas musicales, grabaciones de lluvia y rayos, rezos y cantos de los diversos momentos rituales, danzas, campanas, etc., seccionados en carpetas o dispuestos en una ingeniosa animación que muestra el calendario ritual huave y todos los campos sonoros y visuales correspondientes a cada festividad. Es, pues, un libro que logra dar
al lector una experiencia completa de la sonoridad de San Mateo del mar, sus significados y estructuras.
Konsep Keluarga Ideal dalam Al-Qur’an: Kajian Tafsir Tematik
Authors: Djuned Muslim , Husna Asmaul 
Published: March 2022

Marriage is a noble act and the dream of every normal human being, with the aim of becoming a sakinah, mawaddah, and rahmah family. The Qur’an commands Muslims to create harmony in the family, and the Qur’an has also explained that the ideal family in Islam is a family that upholds the rights and obligations of family members. It's just that in reality, not everyone succeeds in achieving this goal, some even end in failure and divorce. Based on the problems above, this paper will examine the interpretation of the scholars regarding the verses related to the family and observe the criteria for the ideal family in Islam. This research includes library research using the mawdhu'i data analysis method, namely by collecting Qur'anic verses that have relevance to the ideal family. The data sources in this study are the Book of Tafsir al-Mishbāh, Tafsir al-Nūr, and the Book of Tafsir fī ilālil al-Qur'ān. The results of the study show that, first: the Qur’an instructs Muslims to settle down and look after their families. Second: The harmony of a family is largely determined by the moral values of each family member. Third: Fostering an ideal family requires awareness among each family member about the rights, obligations, and responsibilities of each family member. Fostering an ideal family is part of maintaining the tranquility and integrity of society and the realization of the Qur'anic generation. Berumah tangga termasuk perbuatan mulia dan dambaan setiap insan yang normal, dengan tujuan menjadi keluarga sakinah, mawaddah dan warahmah. Alquran memerintah kepada umat Islam untuk menciptakan keharmonisan dalam keluarga, dan Alquran juga telah menjelaskan bahwa keluarga yang ideal dalam Islam adalah keluarga yang menjunjung tinggi hak dan kewajiban anggota keluarganya. Hanya saja dalam realitasnya tidak semua orang berhasil mencapai tujuan tersebut, bahkan ada yang berakhir dengan kegagalan dan perceraian. Berdasarkan permasalahan di atas, maka tulisan ini akan menelaah tentang penafsiran para ulama tentang ayat-ayat yang berkaitan dengan keluarga serta melihat kriteria-kriteria keluarga ideal dalam Islam. Penelitian ini termasuk penelitian kepustakaan dengan metode analisis data secara mawdhu’i, yaitu dengan menghimpun ayat-ayat Alquran yang memiliki relevansi dengan keluarga ideal. Sumber data dalam kajian ini adalah Kitab Tafsir al-Mishbāh, Tafsir al-Nūr, dan Kitab Tafsir fī Ẓilālil al-Qur’ān. Hasil penelitian menunjukkan bahwa, pertama: Alquran memerintahkan umat Islam untuk berumah tangga dan memelihara keluarganya. Kedua: Keharmonisan suatu keluarga sangat ditentukan oleh nilai-nilai akhlak yang dimiliki setiap anggota keluarga. Ketiga: Membina keluarga ideal perlu adanya kesadaran antara setiap anggota keluarga tentang hak, kewajiban, dan tanggung jawab masing-masing anggota keluarga. Membina keluarga yang ideal merupakan bagian dari menjaga ketenangan dan keutuhan masyarakat serta terwujudnya generasi qurani.
Problematika Penulisan Al-Qur’an dengan Rasm Usmani pada Al-Qur’an Cetakan Indonesia dan Malaysia
Authors: Zaini Muhammad , Mat Jusoh Nor Hafizah Bin 
Published: March 2022

The Qur'an is a direct miracle of the Prophet Muhammad and the main source in Islam. Therefore, the Qur'an needs to be kept seriously, not only in understanding and interpreting it, but also in knowing the history of its descent, the form of the letters, and how the letters are formed. Rasm Usmani is Rasm al-Qur'an which has been agreed upon by the companions of the Prophet and is used as a guide and reference standard for writing the Qur'an by Muslims until now. However, there are still many prints of the Qur’an that violate Rasm Usmani. from the background of problem above, this study aims to find out how the history of the writing of the Qur'an, the background of the emergence of Rasm Usmani and the rules for writing verses of the Qur'an in Rasm Usmani. This research is a literature study with a historical approach. The results showed that the writing of the Qur'an was the sunnah of the Prophet which was followed by ijmak (agreement) by all scholars, because the writing was in the form of tauqifiyyah which was carried out under the supervision of the Prophet. Rasm Usmani is the writing of the verses of the Qur'an which was used and approved by Caliph Usman when the process of writing the Qur'an was carried out. The Uthmani Rasm has been agreed upon by the scholars, so that the Rasm must be followed in its entirety by not adding or subtracting a single letter. Al-Qur’an merupakan mukjizat Nabi Muhammad saw. secara langsung dan sumber utama dalam Islam. Karena itu al-Qur’an perlu dijaga secara sungguh-sungguh, tidak hanya pada memahami dan menafsirkannya, tapi juga mengetahui sejarah turunnya, bentuk huruf-hurufnya, dan bagaimana bentuk hurufnya. Rasm Usmani merupakan Rasm al-Qur’an yang telah disepakati sahabat Rasulullah serta dijadikan pedoman dan standar rujukan penulisan al-Qur’an oleh kaum muslim sampai sekarang. Namun, masih terdapat banyak cetakan al-Qur’an yang menyalahi Rasm Usmani. Berangkat dari latar belakang masalah di atas, penelitian ini bertujuan untuk mengetahui bagaimana sejarah penulisan al-Qur’an, latar belakang munculnya Rasm Usmani serta kaidah-kaidah penulisan ayat-ayat al-Qur’an dalam Rasm Usmani. Penelitian ini bersifat kepustakaan dengan pendekatan historis. Hasil penelitian menunjukkan bahwa penulisan al-Qur’an adalah sunnah Rasulullah yang diikuti secara ijmak (sepakat) oleh seluruh ulama, karena penulisannya berbentuk tauqifiyyah yang dilakukan di bawah pengawasan Nabi. Rasm Usmani merupakan penulisan ayat-ayat al-Qur’an yang digunakan dan disetujui oleh Khalifah Usman ketika proses penulisan al-Qur’an dilakukan. Rasm Usmani telah disepakati para ulama, sehingga rasm itu harus diikuti secara utuh dengan tidak menambah atau mengurangi satu hurufpun.
Konsep Deradikalisasi Pemahaman Al-Qur’an Nasaruddin Umar
Authors: Nurullah Nurullah , Taqwiya Taqwiya 
Published: March 2022

Understanding of the Qur'an is growing in various circles. Starting from an understanding that presents Islamic values to an understanding that damages the image of the Qur'an and Islam itself. Like several verses related to war, they are taken exclusively as well as subjectively and textually which results in the emergence of an understanding that these verses are legitimacy and advice to fight using violence. This understanding is often categorized as a radical understanding. The deradicalization of the understanding of the Qur'an is an attempt to shift a radical understanding into a more moderate one. This paper aims to determine the concept and implications of deradicalization of Nasaruddin Umar's understanding of the interpretation of verses with the theme of war. This qualitative literature research is carried out by analyzing data and documents related to the discussion theme. The results showed that Nasaruddin Umar directed the understanding and interpretation of the Qur'an through a contextual approach. The implications of the concept are to give birth to a special concept of war in the perspective of the Qur'an. The Qur'an does legitimize the existence of war, but the legitimacy of the war has certain legal indications. Pemahaman terhadap al-Qur`an semakin berkembang di berbagai kalangan. Mulai dari pemahaman yang mempresentasikan nilai-nilai keislaman hingga pemahaman yang merusak image al-Qur`an dan Islam sendiri. Seperti beberapa ayat yang terkait dengan peperangan, dipahami secara eksklusif maupun subjektif dan tekstual yang mengakibatkan munculnya pemahaman bahwa ayat-ayat tersebut sebagai legitimasi dan anjuran untuk berperang dengan menggunakan kekerasan. Pemahaman ini sering dikategorikan sebagai pemahaman yang radikal. Deradikalisasi pemahaman al-Qur`an merupakan upaya mengalihkan pemahaman yang radikal menjadi lebih moderat. Tulisan ini bertujuan untuk mengetahui konsep dan implikasi deradikalisasi pemahaman Nasaruddin Umar terhadap penafsiran ayat-ayat dengan tema peperangan. Kajian kepustakaan yang bersifat kualitatif ini dilakukan dengan menganalisa data dan dokumen yang terkait dengan tema bahasan. Hasil penelitian menunjukkan bahwa Nasaruddin Umar mengarahkan pemahaman dan interpretasi Alquran melalui pendekatan kontekstual. Implikasi dari konsep yang ditawarkan tersebut melahirkan konsep khusus mengenai peperangan dalam perspektif al-Qur’an. Al-Qur’an memang melegitimasi adanya peperangan akan tetapi tegitimasi terhadap peperangan tersebut memiliki indikasi hukum tertentu.
TINJAUAN FIQH MUAMALAH TERHADAP PELAKSANAAN SISTEM OYOTAN DAN BAWONAN DI DESA MRISEN KECAMATAN JUWIRING KABUPATEN KLATEN
Authors: Isnaini Risma Nur 
Published: March 2022

ABSTRACTThis study discusses the problem of muamalah in Mrisen Village, Juwiring District, Klaten Regency in renting rice fields using oyotan and bawonan systems. The data of this research were obtained through interviews with parties involved in the rice field rental contract with the oyotan and bawonan system, and through documentation. In conducting research, the method used in this research is the method of field research or field research and the data is analyzed using the deductive method. This research uses contract theory, ijarah theory, and mukhabarah theory. The results showed that the implementation of the oyotan and bawonan system, namely renting rice fields with harvest counts and giving the harvest, as long as the rental period was managed by the tenants, the maintenance costs were borne by the tenants, but in the middle of the agreement there was an addition of oyot and the rice fields were managed by the land owner for an uncertain period. According to the wishes of the land owner and the owner still receives the agreed amount of bawonan (harvest). In this practice, there are two contracts, namely the ijÄrah and MukhÄbarah contracts. So in Fiqh Muamalah the oyotan system should not be implemented because it contains gharar or it is unclear the end of the lease period.Keywords: Bawonan; Ijarah; Oyotan.Â ABSTRAKPenelitian ini membahas tentang persoalan muamalah di Desa Mrisen Kecamatan Juwiring Kabupaten Klaten dalam sewa-menyewa sawah yang menggunakan sistem oyotan dan bawonan. Data penelitian ini diperoleh melalui wawancara dengan para pihak yang terkait dalam akad sewa-menyewa sawah dengan sistem oyotan dan bawonan, dan melalui dokumentasi. Dalam melakukan penelitian, metode yang digunakan dalam penelitian ini adalah metode field research atau penelitian lapangan serta data dianalisis dengan metode deduktif. Penelitian ini menggunakan teori akad, teori ijarah, serta teori mukhabarah. Hasil penelitian menunjukkan bahwa pelaksanaan sistem oyotan dan bawonan yaitu sewa menyewa sawah dengan hitungan panen dan pemberian hasil panen, selama masa sewa dikelola penyewa maka biaya perawatan ditanggung penyewa, namun di tengah perjanjian terjadi penambahan oyot dan sawah dikelola pemilik lahan untuk jangka waktu yang tidak menentu sesuai keinginan pemilik lahan serta pemilik tetap menerima bawonan (hasil panen) sesuai jumlah yang disepakati. Dalam praktek tersebut terjadi dua akad yaitu akad ijÄrah dan MukhÄbarah. Maka dalam Fiqh Muamalah sistem oyotan tidak boleh dilaksanakan karena mengandung gharar atau ketidakjelasan berakhirnya waktu sewa.Kata Kunci: Bawonan; Ijarah; Oyotan.
A Life Cycle Model of Firm Value
Authors: Hiemann Moritz 
Published: March 2022

ABSTRACT
Most business valuation formulas are designed for profitable firms experiencing constant growth, even though in practice firms tend to transition from loss-making, high-growth startups to mature, stable enterprises. This paper introduces a life-cycle valuation model that accommodates this evolution in growth and profitability by treating investment expenditures and revenues as a function of firm age. The model's predictions regarding the time dynamics of common valuation multiples and financial ratios align well with observed financial data. The life cycle model can be estimated at the firm level from a few basic accounting variables and delivers estimates both of firm value and of the firm's cost of capital. Firm value estimates show a log-correlation with observed stock market values of more than 90 percent.
JEL Classifications: D21; G12; G17; G31; G32.
Peningkatan Potensi Peternak Kambing dan Budidaya Nila Mentari di Wilayah Prm Desa Blagung, Kecamatan Simo, Kabupaten Boyolali
Authors: Putri Eskasari , Sasongko Noer , Achyani Fatchan 
Published: March 2022

Dalam rangka meningkatkan perekonomian melalui potensi yang ada di lingkungan pedesaan, maka upaya-upaya yang dilakukan PRM Desa Blagung, Kecamatan Simo, Kabupaten Boyolali membentuk kelompok-kelompok kerja yang terdiri kelompok Peternak Kambing Mentari dan Budidaya Ikan Nila Mentari. Namun upaya yang telah dilakukan PRM Desa Blagung, Kecamatan Simo, Kabupaten Boyolali masih mengalami beberapa kendala seperti, ketrampilan untuk pengembangan usaha, pemasaran, dan pencatatan laporan keuangan. Melalui pengabdian masyarakat ini Universitas Muhammadiyah Surakarta bersama PRM Desa Blagung, Kecamatan Simo, Kabupaten Boyolali ikut serta dalam pembinaan dan pengembangan kelompok Peternak Kambing Mentari dan Budidaya Ikan Nila Mentari di bidang pengembangan usaha, pemasaran, dan pencatatan laporan keuangan. Metode pelaksanaan pengabdian masyarakat ini yaitu pelatihan dan pendampingan pada kelompok Peternak Kambing Mentari dan Budidaya Ikan Nila Mentari