bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the nature of perceived treatment burden: a study to compare treatment burden measures in adults with cystic fibrosis
Authors: Altabee Rana , Carr Siobhan B. , Abbott Janice , Cameron Rory , Office Daniel , Matthews Jessie , Simmonds Nicholas , Cosgriff Rebecca , Turner David , Whitty Jennifer 
Published: May 2022

Background: Despite the importance of reducing treatment burden for people with cystic fibrosis (CF), it has not been fully understood as a concept. This study aims to quantify the treatment burden perceived by CF adults and explore the association between different validated treatment burden measures. Methods: This is a cross-sectional observational study of CF adults attending a single large UK adult center. Participants completed an online survey that contained three different treatment burden scales; CF Questionnaire-Revised (CFQ-R) subscale, CF Quality of Life (CFQoL) subscale, and the generic multimorbidity treatment burden questionnaire (MTBQ). Results: Among 101 participants, the median reported treatment burden by the CFQ-R subscale was 55.5 (IQR 33.3 – 66.6), the CFQoL subscale was 66.6 (IQR 46.6 – 86.6), and the MTBQ reversed global score was 84.6 (IQR 73.1 – 92.3). No correlation was found between respondents’ demographic or clinical variables and treatment burden measured via any of the three measures. All treatment burden measures showed correlations against each other. More treatments were associated with high treatment burden as measured by the CFQ-R, CFQoL subscales, and the MTBQ. However, longer treatment time and more complex treatment plans were correlated with high treatment burden as measured by the CFQ-R and CFQoL subscales, but not with the MTBQ. Conclusions: Treatment burden is a substantial issue in CF. Currently, the only available way to evaluate it is with the CF-specific quality of life measure treatment burden subscales (CFQ-R and CFQoL); both indicated that treatment burden increases with more treatments, longer treatment time, and more complex treatments.
Diálogo universitario sobre actualidades en ciencias naturales: resultados del primer coloquio organizado por el Departamento de Ciencias Básicas de la Fundación Universitaria del Área Andina - sede Bogotá
Authors: Céspedes Guevara Nelly Yolanda , Adame Rodríguez Juan David 
Published: May 2022

El Coloquio realizado durante el año 2019 fue espacio académico y formativo que desde diversas experiencias permitió identificar aquellas tendencias que en la actualidad se encuentran asociadas a las prácticas investigativas en el campo de las ciencias naturales, presentando un nuevo panorama desde la reflexión que pueda incidir en la transformación de una educación superior más ajustada a las demandas de la sociedad.
La investigación permanente en las ciencias naturales trasciende en la innovación tecnológica y científica en el campo de la salud, la industria, el deporte y la educación, potencializando el crecimiento y consolidando el desarrollo educativo local, nacional e internacional. Las temáticas que fueron asociadas a las diferentes participaciones en el marco del coloquio se orientaron al campo de las ciencias naturales como: biología celular, biología molecular, biotecnología, biología vegetal, biología animal, ecología y ambiente, uso de recursos naturales, microbiología, etnobotánica, química aplicada, enseñanza de las ciencias naturales.
Perancangan Sistem Informasi Kerja Praktik Berbasis Web
Authors: Setiawan Ridwan , Agustin Yoga Handoko , Ningsih Intan Hartanti Rahman 
Published: May 2022

Kerja praktik merupakan kegiatan yang mengimplementasikan ilmu-ilmu yang didapat saat dibangku perkuliahan ke dalam dunia kerja. Tujuan dari penelitian ini adalah untuk merancang sistem informasi yang dapat mengelola kegiatan kerja praktik mahasiswa ITG. Penelitian ini menggunakan metodologi Rational Unified Approach (RUP) dengan tahapan yang digunakan yaitu tahapan inception, elaboration, dan construction dengan pemodelan sistem menggunakan Unified Modelling Language (UML) di mana pemodelan yang dipakai yaitu use case diagram, activity diagram, sequence diagram, dan class diagram. Hasil dari penelitian ini adalah dibangunnya sistem informasi yang dapat mengelola kegiatan kerja praktik dan monitoring penyelesaian kerja praktik untuk mahasiswa dalam proses pendaftaran sampai pelaksanaan penyelesaian kerja praktik di industri, serta bagi mahasiswa dapat mencari informasi tempat dilaksanakan kegiatan kerja praktik sebelumnya sebagai bahan rujukan.
Pembinaan Kesehatan Mental dan Reproduksi Bagi Remaja Masjid AMIN, Sleman, Yogyakarta
Authors: Arini Merita , Primastuti Harumi Iring , Hidayanti Lailatul , Aji Wingga Chrisna , Affia Farida Nur , Khoirunnisa Sarah Disa 
Published: May 2022

Adolescence and early adulthood are transitional periods that vulnerable to mental and reproductive health disorders. This community service aimed to provide education about mental and reproductive health to increase knowledge and prevent both health problems in partners. A cycle of action research method was conducted by involved partners to determine the priority of the problems and how to solve them. Eighteen participants were involved with mental and reproductive health education session. As a result, there was an improvement of the mean score of participants' knowledge from 9,11 become 11,50 (maximum score=15) [p=0,001] and indicators achievement of the activeness of participants in participating in this community service activity. In conclusion, the educational session helped increase participants' mental and reproductive health knowledge. Multisectoral participation is needed to assist youth in implementing healthy lifestyle behaviors to maintain mental and sexual health.

ABSTRAK
Kelompok usia remaja dan dewasa awal merupakan masa transisi yang rentan dengan masalah kesehatan mental dan reproduksi. Tujuan dari pengabdian masyarakat ini adalah memberikan edukasi mengenai kesehatan mental dan reproduksi untuk meningkatkan pengetahuan dan mencegah kedua masalah kesehatan tersebut pada mitra. Pendekatan yang dilakukan pada pengabdian masyarakat ini adalah satu siklus action research di mana tim pengabdian melibatkan mitra dalam penentuan prioritas masalah yang diselesaikan serta bagaimana cara menyelesaikannya. Sesi edukasi dilakukan terhadap 18 orang anggota organisasi remaja AMIN tersebut. Hasil pengabdian ini adalah meningkatnya rerata skor pengetahuan remaja mengenai kesehatan mental dan reproduksi dari 9,11 menjadi 11,50 (skor maksimal 15) [p=0,001], serta tercapainya indikator keaktifan partisipan dalam berpartisipasi pada kegiatan pengabdian masyarakat ini. Sebagai kesimpulan, sesi edukasi bermanfaat meningkatkan pengetahuan partisipan tentang kesehatan mental dan reproduksi. Dibutuhkan peran serta multisektor untuk mendampingi remaja dalam menerapkan perilaku hidup sehat untuk menjaga kesehatan mental dan seksual.
Permeability of Bituminous Coal to CH4 and CO2 Under Fixed Volume and Fixed Stress Boundary Conditions: Effects of Sorption
Authors: Liu Jinfeng , Spiers Christopher J. 
Published: May 2022

Permeability evolution in coal reservoirs during CO2-enhanced coalbed methane (ECBM) production is strongly influenced by swelling/shrinkage effects related to sorption and desorption of CO2 and CH4, respectively. Recent research has demonstrated fully coupled stress–strain–sorption–diffusion behavior in small samples of cleat-free coal matrix material exposed to a sorbing gas. However, it is unclear how such effects influence permeability evolution at the scale of a cleated coal seam and whether a simple fracture permeability model, such as the Walsh elastic asperity loading model, is appropriate. In this study, we performed steady-state permeability measurements, to CH4 and CO2, on a cylindrical sample of highly volatile bituminous coal (25 mm in diameter) with a clearly visible cleat system, under (near) fixed volume versus fixed stress conditions. To isolate the effect of sorption on permeability evolution, helium (non-sorbing gas) was used as a control fluid. All flow-through tests reported here were conducted under conditions of single-phase flow at 40°C, at applied Terzaghi effective confining pressures of 14–41 MPa. Permeability evolution versus effective stress data were obtained under both fixed volume and fixed stress boundary conditions, showing an exponential correlation. Importantly, permeability (κ) obtained at similar Terzaghi effective confining pressures showed κhelium &gt; κCH4 &gt;&gt; κCO2, while κ-values measured in the fixed volume condition were higher than those in the fixed stress case. The results show that permeability to CH4 and CO2, under in situ conditions where free swelling of rock is not possible, is strongly influenced by the coupled effects of 1) self-stress generated by constrained swelling, 2) the change in effective stress coefficient upon sorption, 3) sorption-induced closure of transport paths independently of poroelastic effect, and 4) heterogeneous gas penetration and equilibration, dependent on diffusion. Our results also show that the Walsh permeability model offers a promising basis for relating permeability evolution to in situ stress evolution, using appropriate parameter values corrected for the effects of stress–strain–sorption.
Outcomes of a Telephonic Postnatal Intervention for Mothers and Babies in Mopani District, Limpopo, South Africa
Authors: Mutyambizi Chipo , Dunlop Jackie , Ndou Rendani , Struthers Helen , McIntyre James , Rees Kate 
Published: May 2022

BackgroundThe postnatal period is a critical period for the health of both mother and infant. Studies show that postnatal care reduces neonatal mortality and other adverse mother and child health outcomes. While the World Health Organization recommends four postnatal care contacts, South African guidelines only specify three, excluding a 7-14-day post-birth contact. This study aimed to assess whether a telephonic contact at 7-14 days following delivery had any effect on use of additional postnatal services.MethodsA randomized controlled trial design was used to address the study objectives. Two groups of new mothers were randomly allocated to either receive the 7-14-day telephonic contact or not from a research nurse. Data for this study was collected at Maphutha L Malatjie Hospital (MLMH). Descriptive analysis was performed first, then a multivariable logistic regression analysis was conducted to assess the factors associated with access to other health care services.ResultsA total of 882 mothers were recruited, 854 (97%) were classified as high risk, 28 (3%) were classified as low risk. 417 (49%) of the high risk received the 7-14-day call (intervention group) whilst the remainder of 437 (51%) from the high risk plus all mothers classified as low risk (28) did not receive the call (control group). 686 (78%) of all mothers received the 3 month follow up call. The call showed that 17 mothers from the control group and 10 mothers from the intervention group accessed other healthcare services. We find that hypertension (3.28; 1.06 −10.10), mental health risk (2.82; 1.25 −6.38), PV bleeding during pregnancy (18.33; 1.79–187.61), problem during labor (4.40; 1.280–15.13) were positively associated with access to other health services, with statistically significant associations (p-value &lt; 0.05). We found statistically insignificant associations between receiving the 7-14-day call and accessing other health care services.ConclusionThe 7-14-day call had no statistically significant impact on access to other health services, however, high levels of satisfaction with the call may point to an unmet need for care at this time. It is important to investigate other innovative solutions to postnatal care improvement in South Africa.
Role of IL-25 on Eosinophils in the Initiation of Th2 Responses in Allergic Asthma
Authors: Peng Bo , Sun Lin , Zhang Meng , Yan Huacheng , Shi Guochao , Xia Zhenwei , Dai Ranran , Tang Wei 
Published: May 2022

BackgroundEosinophils act as a secondary antigen-presenting cell (APC) to stimulate Th cell responses against antigens. IL-25 plays a significant role in eosinophil activation in allergic asthma. The role of IL-25 on the classic APC functions of dendritic cells has been elucidated. However, whether IL-25 facilitates eosinophils for antigen presentation is unknown.ObjectiveTo elucidate the role of IL-25 on eosinophils antigen presenting function during allergic asthma and its related mechanism.MethodsEosinophils from allergic asthma subjects were cultured with IL-25 and HDM to identify the co-stimulator molecules expression. Co-cultures of patient eosinophils and autologous naïve CD4+ T cells in the same culture system were to explore whether eosinophils had the capacity to promote Th cell differentiation in response to IL-25 engagement. In asthma mouse model, IL-25-/- mice were exposed to HDM to investigate the effect of IL-25 on eosinophils during the sensitization phase. The impact of IL-25 on the capacity for eosinophils taking up antigens was evaluated. Mouse bone marrow derived eosinophils (BmEOS) were co-cultured with naïve CD4+T cells sorted from spleens under HDM and IL-25 stimulation to identify T cell differentiation.ResultsIL-25 upregulated HLA-DR, PD-L1, and OX-40L expression on eosinophils from allergic asthma patients. IL-25 and HDM co-sensitized eosinophils promoted Th2 differentiation. In mouse model, IL-25-/- mice experienced restrained allergic pulmonary inflammation and reduced eosinophils recruitment and antigen uptake capacity during the early sensitization phase. In vitro, IL-25 promoted antigen uptake by eosinophils. In BmEOS and naïve CD4+T cells co-culture, IL-25 accreted the proportion of CD4+Th2 cells, which was absent in CD4+T cells culture alone.ConclusionOur data identify a novel role of IL-25 in enhancing eosinophils antigen uptake and co-stimulator molecules expression to induce Th2 priming in the context of allergic inflammation.
Serum Metabolomics Benefits Discrimination Kidney Disease Development in Type 2 Diabetes Patients
Authors: Peng Xiaofeng , Wang Xiaoyi , Shao Xue , Wang Yucheng , Feng Shi , Wang Cuili , Ye Cunqi , Chen Jianghua , Jiang Hong 
Published: May 2022

BackgroundDiabetic kidney disease (DKD) is the primary cause of end-stage renal disease, raising a considerable burden worldwide. Recognizing novel biomarkers by metabolomics can shed light on new biochemical insight to benefit DKD diagnostics and therapeutics. We hypothesized that serum metabolites can serve as biomarkers in the progression of DKD.MethodsA cross-sectional study of 1,043 plasma metabolites by untargeted LC/MS among 89 participants identified associations between proteinuria severity and metabolites difference. Pathway analysis from differently expressed metabolites was used to determine perturbed metabolism pathways. The results were replicated in an independent, cross-sectional cohort of 83 individuals. Correlation and prediction values were used to examine the association between plasma metabolites level and proteinuria amount.ResultsDiabetes, and diabetic kidney disease with different ranges of proteinuria have shown different metabolites patterns. Cysteine and methionine metabolism pathway, and Taurine and hypotaurine metabolism pathway were distinguishable in the existence of DKD in DC (diabetes controls without kidney disease), and DKD with different ranges of proteinuria. Two interesting tetrapeptides (Asn-Met-Cys-Ser and Asn-Cys-Pro-Pro) circulating levels were elevated with the DKD proteinuria progression.ConclusionsThese findings underscore that serum metabolomics provide us biochemical perspectives to identify some clinically relevant physiopathologic biomarkers of DKD progression.
Immunogenicity and Safety of a Novel 13-Valent Pneumococcal Vaccine in Healthy Chinese Infants and Toddlers
Authors: Zhao Yuliang , Li Guohua , Xia Shengli , Ye Qiang , Yuan Lin , Li Hong , Li Jiangjiao , Chen Jingjing , Yang Shuyuan , Jiang Zhiwei , Zhao Guoqing , Li Rongcheng , Li Yanping , Xia Jielai , Huang Zhen 
Published: May 2022

BackgroundTo determine the non-inferiority of the seven common serotypes (4, 6B, 9V, 14, 18C, 19F, and 23F) in the 13-valent pneumococcal conjugate vaccine (PCV13) with each serotype conjugated to a tetanus toxoid carrier protein and adsorbed on aluminum phosphate and the superiority of its six additional serotypes (1, 3, 5, 6A, 7F, and 19A) to the serotypes in the PCV7.MethodsParticipants were evenly randomized in a 1:1 ratio into either the PCV13 or PCV7 groups, to receive three doses of the vaccine at the age of 3, 4, and 5 months, respectively, and a booster dose between 12 and 15 months of age. Serotype-specific antibodies were measured using a standardized enzyme-linked immunosorbent assay (ELISA) and opsonophagocytic activity (OPA) microcolony assay method.ResultsA total of 1,040 healthy infants were enrolled. All the seven common serotypes in the PCV13 were non-inferior to those in the PCV7 in terms of the serotype-specific IgG production induced; however, non-inferiority was not shown for serotype 6B after the infant series. The proportion of subjects who reached OPA antibody titers ≥ 1:8 in the PCV13 group was 89.25% or higher. Local reactions and systemic events were mild or moderate in severity and similar between the two groups. No new safety signals were observed.ConclusionThe newly developed PCV13 was immunogenic for all serotypes and had a comparable safety profile to the marketed PCV7.
Clinical Significance of Early Carcinoembryonic Antigen Change in Patients With Nonmetastatic Colorectal Cancer
Authors: Jo Younghoo , Lee Jae-Hoon , Cho Eun-Suk , Lee Hye Sun , Shin Su-Jin , Park Eun Jung , Baik Seung Hyuk , Lee Kang Young , Kang Jeonghyun 
Published: May 2022

BackgroundThis study aimed to evaluate the prognostic significance of preoperative, postoperative, and trajectory changes in carcinoembryonic antigen (CEA) levels in patients with colorectal cancer (CRC).MethodsThis retrospective study included patients who underwent surgical resection for nonmetastatic CRC. The optimal cutoff values of preoperative CEA (CEA-pre), early postoperative CEA (CEA-post), and CEA level change (CEA-delta) were determined to maximize the differences in overall survival (OS) among groups. The patients were divided into three groups according to CEA-trend: normal, low CEA-pre; normalized, high CEA-pre/low CEA-post; elevated, high CEA-pre/high CEA-post. The integrated area under the curve (iAUC) was used to compare the discriminatory power of all variables.ResultsA total of 1019 patients diagnosed with stage I–III CRC were enrolled. The optimal cutoff values of CEA level were determined as 2.3 ng/mL for CEA-pre, 2.3 ng/mL for CEA-post, and -0.93 ng/mL for CEA-delta. Although subgroup dichotomization showed that CEA-pre, CEA-post, CEA-delta, and CEA-trend were all associated with OS in univariate analysis, CEA-trend was the only independent prognostic factor in multivariate analysis. The iAUC of CEA-trend was superior to that of CEA-pre, CEA-post, and CEA-delta. Compared with the normal group, the normalized group showed worse OS (p=.0007) in stage II patients but similar OS (p=.067) in stage III patients.ConclusionThe optimal cutoff value of CEA level in the preoperative and postoperative periods was determined to be 2.3 ng/mL, and the combination of CEA-pre and CEA-post showed better prognostic stratification. However, its prognostic significance may differ depending on the CRC stage.
Experiences of Discrimination and Everyday Racism Among Children and Adolescents With an Immigrant Background – Results of a Systematic Literature Review on the Impact of Discrimination on the Developmental Outcomes of Minors Worldwide
Authors: Metzner Franka , Adedeji Adekunle , Wichmann Michelle L.-Y. , Zaheer Zernila , Schneider Lisa , Schlachzig Laura , Richters Julia , Heumann Susanne , Mays Daniel 
Published: May 2022

Experiences of discrimination such as everyday racism can negatively affect the mental and physical health of children and adolescents with an immigrant background and impair their integration process in the host societies. Although experiences of racism are part of the everyday life of many minors affected by the process of “Othering” (e.g., those with an immigrant background), an overview of empirical findings is missing for this age group worldwide. A systematic review was conducted to identify and analyze international research on the impact of discrimination on the developmental outcomes and integration of immigrant children and adolescents. Three scientific databases were systematically searched up to June 11, 2021. A total ofk= 4,769 identified publications were reviewed based on inclusion and exclusion criteria in terms of the PICOS format by independent reviewers. Thirty-four primary studies published between 1998 and 2021 met all inclusion criteria. The samples examined were mainly migrant youth (k= 30), with onlyk= 2 studies assessing refugee youth andk= 1 study assessing both migrant and refugee youth. The majority of included studies assessed perceived discrimination, with onlyk= 1 study directly assessing experiences of racism. The association between discrimination or racism and developmental outcomes was assessed by the included studies within the three main topics of (a) mental and physical health-related outcomes (k= 30, e.g., self-esteem, depressive symptoms), (b) school-related outcomes (k= 6, e.g., academic achievement), and (c) other developmental outcomes (k= 13, e.g., misconduct or delinquency). Data collection procedures were implemented, and findings on minors’ developmental outcomes and integration process who experience discrimination and racism were summarized and discussed. The current review suggests experienced (racial) discrimination as a negative predictor of children and adolescents’ (mental) health-related outcomes, while no clear results could be found for the association between discrimination and school-related outcomes. A need for more empirical research focusing on the path and (possibly) indirect link between discrimination and children and adolescents’ school-related outcomes as well as resulting school recommendations and the chosen career path was derived.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=260291], identifier [CRD42021260291].