bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARISON OF OCCLUSAL VERTICAL DIMENSION USING ANALYSIS OF SEVERAL VERSIONS OF DIGITAL PHOTO SOFTWARES
Authors: Purba Rani , Kuntum Feby , Rizkika Puput , W. Rais Sri , Prasetya Beumaputra Arya 
Published: September 2022

Digital photo analysis is an alternative method of measuring the vertical dimension occlusion (OVD) in the denture processing by using graphic design softwares such as bitmap and vector-based software. The 2020 version of bitmap software has advantages such as online data storage, and upsampling feature that is used to improve image quality as well as the 2020 version of vector software. This study aimed to compare the results of OVD measurements using the analysis of several versions of digital photo softwares and direct measurements (Willis method). Methods: This study was an analytic observational study with a cross-sectional approach. The total sample in this study was 30 students of the Sriwijaya University Dentistry Study Program from previous studies, divided into 5 groups; group I Willis method, group II 2012 version of bitmap, group III 2012 version of vector, group IV 2020 version of bitmap, group V 2020 version of vector software. The OVD was measured from subnation to menton in occlusion using the Willis method and several digital photo software analysis methods. The data were tested using one-way ANOVA test. Results: The results of the one-way ANOVA test showed OVD differences of the direct method and digital photo software methods were not significant (p>0.05). Conclusion: There was no difference in the results of the occlusal vertical dimension between the groups.
THE FINAL YEAR OF MEDICAL SCHOOL TOGETHER WITH THE COVID-19 PANDEMIC WAS RELATED TO EMOTIONAL EATING BEHAVIOR
Authors: Abdurrahman Muhammad Ihsan , Husin Syarif , Lusiana Evi , Kurniati Ardesy Melizah , Suciati Tri 
Published: September 2022

Emotional eating, or overeating to ease unpleasant emotions, is one of the harmful impacts of stress. Students in their final year of college are more susceptible to emotional eating because their stress level is high. The main purpose of this study was to examine the association between stress and emotional eating behavior in final-year Medical Education Study Program students of Universitas Sriwijaya. Data was collected in January 2021, with as many as 121 students from the 2017 class participating. The Perceived Stress Scale (PSS) questionnaire was used in this study to assess students' stress levels, while the Dutch Eating Behaviour Questionnaire (DEBQ) was used to assess emotional eating behavior. The Chi-square test was used to examine the data. Overall, this study discovered that 19 students (15.7 percent) were classified as having low stress, 82 students (67.8 percent) as having moderate stress, and 20 students (16.5 percent) as having high stress. Emotional eating affects up to 74 (61.2%) of students, with female students experiencing more. The Chi-square test yielded p=0.018 (p 0.05) and OR 3.282 (1.186-9.081) indicating a significant link between stress and emotional eating behavior in final-year Medical Education Study Program students of Universitas Sriwijaya.
On the Issue of Common Prosperity in the New Era and New Situation
Authors: Li Guangzhe 
Published: September 2022

The way wealth is created and distributed is a concentrated reflection of the social form of a country. Over the past 40 years of reform and opening up, the economic and social foundation is in place for further substantive progress in promoting common prosperity. However, unbalanced and inadequate development still exists. Engels profoundly pointed out that "the conditions under which people produce and exchange vary from country to country, and from generation to generation in each country. Therefore, political economy cannot be the same for all historical epochs. "In the comparison and understanding of different experiences, lessons are drawn from multiple perspectives.
Legal and regulatory aspects of improving the sanctions policy of Ukraine
Authors: Buhaichuk K. L. 
Published: September 2022

The paper examines the legal nature of sanctions imposed by the UN Security Council and individual states to combat violations of international law. The UN Security Council sanctions have been identified as mainly economic restrictions and other coercive measures imposed for violations of major international human rights conventions and instruments.
A comparative legal analysis of the sanctions policy of the United States of America and the European Union was carried out, on the basis of which it was concluded that the sanctions policy implemented by the European Union and the United States of America is fundamentally different. In the EU, it is implemented in accordance with the institutional documents on the establishment of the European Union, which allow the introduction of restrictive measures against individuals or legal entities and groups or non-governmental organizations. At the same time, US sanctions are imposed on any entity that poses a threat to the US economy, even when its actions are lawful under national law. The US experience with the introduction of “secondary sanctions” is interesting, when a natural or legal person cooperating with sanctioned organizations or individuals may be subject to US economic sanctions.
The content of the Law of Ukraine “On Sanctions” and the practice of its implementation through the decisions of the National Security and Defense Council of Ukraine, which are enacted by Decrees of the President of Ukraine. Based on the above, proposals and recommendations for improving its content are formulated: 1) to determine that sanctions against citizens of Ukraine are an exceptional measure and are applied in case of impossibility of full pre-trial investigation due to their stay outside the jurisdiction of Ukraine; 2) to expand the list of legal grounds for the application of sanctions to citizens of Ukraine by including, in addition to terrorist activities, the commission of crimes against the foundations of national security of Ukraine; 3) to determine an exhaustive list of sanctions to enshrine in it the possibility of restricting access to Internet resources; 4) to establish a mechanism of legal liability for non-compliance with the requirements imposed by sanctions.
The impact of training and retraining of police officers on their competitiveness
Authors: Podorozhnii Y. Y. 
Published: September 2022

Based on the analysis of scientists’ scientific views, the meaning of the concept of “qualification” has been revealed. It has been found that the qualification is a complex characteristic of the employee, which includes the presence of the appropriate level of education, as well as professional skills, abilities, skills, experience in performing certain processes and actions, which together characterize them as an experienced subject of a certain type of work. In fact, qualifications are a factor that determines whether a person can perform a job, such as serving in the police.
Emphasis is placed on the fact that the initial professional training provides an initial level of qualification, which allows to work quite efficiently and comfortably in the bodies and units of the National Police of Ukraine, but the personnel prospects of such employees are truncated.
An analysis of the current legislation, which determines the legal basis for training and retraining of employees of the National Police of Ukraine has been carried out. The peculiarities of training and advanced training of police officers at higher education institution have been revealed.
It has been established that the training of a police officer is an additional element of his/her professional training, which takes place in parallel with his/her main service activity and is aimed at its improvement. As part of in-service training, skills and abilities are developed, as well as the knowledge of a police officer is supplemented in order to ensure that he/she performs his/her duties even more efficiently and effectively. In addition, professional development affects the career of a police officer, as the results of such training are properly designed and recorded in the personal file. It has been stated that the qualification of the employee is inextricably linked with the process of their professional training, acquisition of new skills, abilities, as well as the acquisition of special knowledge. The study of the legal framework has showed that the wider the level of education a police officer has, the higher his/her value to the bodies and units of the National Police of Ukraine. Taken together, these factors allow them to compete with other police officers in terms of professional prospects and opportunities to hold senior positions.
To the problem of optimization of criteria for evaluating the effectiveness of providing the national security of the State
Authors: Kobko Y. V. 
Published: September 2022

It has been argued that the evaluation of the effectiveness of Ukrainian national security is the activities of authorized entities carried out in the prescribed manner, which aims to establish the extent to which measures implemented by the state in the relevant direction, as well as related financial, material technical and human costs, meet the goal.
It has been performed the classification of the relevant criteria, which is most appropriate to divide into the following groups: 1) financial and economic, which include: the level of shadowing of the economy; the level of GDP per capita; the ratio of public debt to GDP; the average level of wages in the state; 2) socio-cultural, in particular: the demographic situation in the country (depopulation rate); the level of legal consciousness of society and cultural development; national consent and unity; a sense of personal security; the level of support of the population of the state; 3) political: stability and effectiveness of public policy (domestic political stability); resilience to ensure a high level of readiness of society and the state to respond to a wide range of threats; the level of democracy, the formation and effectiveness of the legal framework of the rule of law; 4) indicators of combat readiness of the army: the state of the armed forces, their combat capability and combat readiness; logistical, financial support of troops; adequacy of staffing.
Emphasis has been placed on the fact that the list of these criteria is not exhaustive, as they can be expanded by a number of indicators that depend directly on the direction of national security. These criteria are an objective reflection of how effective the legislator is in this area. In addition, the implementation of appropriate evaluation requires the use of various methods: surveys, mathematical modeling, forecasting and more.
3D CNT/MXene microspheres for combined photothermal/photodynamic/chemo for cancer treatment
Authors: Gao Wei , Zhang Weihao , Yu Haipeng , Xing Wenge , Yang Xueling , Zhang Yongguang , Liang Chunyong 
Published: September 2022

MXene nanosheets have shown exciting potential in nanomedicine because of their large surface area, intense near-infrared (NIR) absorbance, and good biocompatibility. However, their development in the direction of treating tumors is constrained by the limitations of existing design methodologies. These methodologies lack control over the size and distribution of tumors. Moreover, their photodynamic therapy (PDT) effect is poor. To address this unmet medical need, a simple strategy that processes MXene with carbon nanotube (CNT) into a three-dimensional (3D) honeycomb structure having anti aggregation capacity was established. The structure can be used in disease phototherapy against tumors, bacteria, and viruses, such as photothermal therapy (PTT), photodynamic therapy (PDT), and multimodal synergistic therapy. In the present study, 3D CNT/MXene microspheres were obtained by the template method and spray-drying method. The microspheres possessed special photothermal effects and photothermal stability under NIR laser irradiation. Furthermore, the developed microspheres could achieve a maximum of 85.6% drug loading capability of doxorubicin (DOX). Under light irradiation at 650 and 808 nm, 3D CNT/MXene microspheres could efficiently produce singlet oxygen due to the effectiveness of CNTs as carries for Titanium Dioxide (TiO2) photosensitizers present on the MXene surface. Furthermore, in vitro studies had showed that 3D CNT/MXene-DOX effectively inhibited the proliferation of HeLa cells. Hence, this study provides a promising platform for future clinical applications to realize PTT/PDT/chemotherapy combination cancer treatment based on MXene.
Assessment of alterations in histone modification function and guidance for death risk prediction in cervical cancer patients
Authors: Zhao Tingting , Liu Bairong , Zhang Mengyuan , Li Shiguo , Zhao Can , Cheng Li 
Published: September 2022

Background: Cervical cancer is the second most lethal malignancy among women, and histone modification plays a fundamental role in most biological processes, but the prognostic value of histone modification in cervical cancer has not been evaluated.Methods: A total of 594 cervical cancer patients from TCGA-CESC, GSE44001, and GSE52903 cohorts were enrolled in the current study, along with the corresponding clinicopathological features. Patients with a follow-up time less than one month were removed. A total of 122 histone modification-associated signaling pathways were obtained from the MSigDB. The activation scores of these pathways were evaluated using the “GSVA” package, differentially expressed genes were identified by the “limma” package, and pathway enrichment was conducted using the “clusterProfiler 4.0” package. The subsequent least absolute shrinkage and selection operator (LASSO) regression analysis was performed using the “glmnet” package, and a prognostic nomogram was established using the “regplot” package. For the prediction of potential therapeutic drugs, we used the data from GDSC2016 and visualized them via “MOVICS”.Results: Nine of 23 histone modification-associated prognostic genes were identified to construct the prognostic signature by LASSO analysis, named the histone modification-associated gene (HMAG) signature. Cervical patients with HMAG-H in TCGA-CESC cohort showed a 2.68-fold change of death risk, with the 95% CI from 1.533 to 4.671 (p &lt; 0.001), as well as the increased death risk of HMAG-H in the GSE44001 cohort (HR: 2.83, 95% CI: 1.370–5.849, p = 0.005) and GSE44001 cohort (HR: 4.59, 95% CI: 1.658–12.697, p = 0.003). We observed the preferable AUC values of the HMAG signature in TCGA-CESC cohort (1-year: 0.719, 3-year: 0.741, and 5-year: 0.731) and GSE44001 cohort (1-year: 0.850, 3-year: 0.781, and 5-year: 0.755). The C-index of the nomogram showed a prognostic value as high as 0.890, while the C-index for age was only 0.562, and that for grade was only 0.542. Patients with high HMAG scores were more suitable for the treatment of CHIR-99021, embelin, FTI-277, JNK-9L, JQ12, midostaurin, PF-562271, pyrimethamine, and thapsigargin, and patients with low HMAG scores were more suitable for the treatment of BMS-536924, CP466722, crizotinib, PHA-665752, rapamycin, and TAE684.Conclusion: We comprehensively evaluated the histone modification status in cervical cancer patients and revealed histone modification-associated prognostic genes to construct the HMAG signature, aiming to provide a new insight into prognosis prediction and precise clinical treatment.
One of the active ingredients in Paeoniae Radix Alba functions as JAK1 inhibitor in rheumatoid arthritis
Authors: Xiao Lu , Lin Shudian , Zhan Feng 
Published: September 2022

Objective: We aimed to explore and verify the mechanism underlying the action of the active ingredients of Paeoniae Radix Alba (PRA) in the treatment of rheumatoid arthritis (RA).Methods: The protein targets of PRA’s six active ingredients and RA were identified. Then, the intersection of the two groups was studied. The drug–target network was constructed, visualized, and analyzed by Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment were performed to analyze these genes. Furthermore, we validated our predictions of the potential targets through a docking study. Finally, the anti-inflammatory effect of Palbinone (PB), one of the active ingredients of PRA, was tested by conducting in vitro and in vivo studies.Results: Six active ingredients of PRA were identified, and 103 overlapping genes were discovered. Functional enrichment analysis indicated that the genes are mostly enriched in IL-17 signaling pathway, Th17 cell differentiation, and the FoxO, ErbB, and TNF signaling pathways. 10 hub genes and two gene cluster modules were identified by Cytoscape. Molecular docking analysis proved that PB was able to bind to the ATP binding site of Janus kinase (JAK)1, thereby acting as a potential inhibitor of JAK1. In vitro and in vivo studies demonstrated that PB exerts its anti-inflammatory role via the inhibition of JAK1.Conclusion: We constructed a multitarget pharmacological network of PRA in RA treatment. PB, one of the active compounds of PRA, was demonstrated to be a promising inhibitor of JAK1.
Efficacy and safety of tranexamic acid for patients with intertrochanteric fractures treated with intramedullary fixation: A systematic review and meta-analysis of current evidence in randomized controlled trials
Authors: Jiang Jiabao , Xing Fei , Zhe Man , Luo Rong , Xu Jiawei , Duan Xin , Xiang Zhou 
Published: September 2022

Background: Tranexamic acid (TXA) has been widely applied to reduce perioperative bleeding. Recently, several studies focused on the administration of TXA in the treatment for with intertrochanteric fracture patients treated with intramedullary fixation. However, the efficacy and safety of TXA in these studies remain controversial. Therefore, we performed this systematic review and meta-analysis to investigate the efficacy and safety of TXA in intertrochanteric fracture patients treated with intramedullary fixation.Methods: We systematically searched electronic databases, including Cochrane, PubMed, and EMBASE, up to 16 May 2022. The efficacy and safety of TXA was evaluated in four aspects, which were bleeding-related outcomes, non-bleeding-related outcomes, thromboembolic events, and other complications. The outcomes of these studies were extracted and analyzed by RevMan Manager 5.4.Results: Finally, nine randomized controlled trials, involving nine hundred and seventy-two intertrochanteric fracture patients treated with TXA, were enrolled in this study. In the bleeding-related outcomes, TXA group was significantly lower than the control group in terms of total blood loss (MD = −219.42; 95% CI, −299.80 to −139.03; p &lt; 0.001), intraoperative blood loss (MD = −36.81; 95% CI, −54.21 to −19.41; p &lt; 0.001), hidden blood loss (MD = −189.23; 95% CI, −274.92 to −103.54; p &lt; 0.001), and transfusion rate (RR = 0.64; 95% CI, 0.49 to 0.85; p = 0.002). Moreover, the postoperative hemoglobin on day 3 of the TXA group was significantly higher than that of the control group (MD = 5.75; 95% CI, 1.26 to 10.23; p = 0.01). In the non-bleeding-related outcomes, the length of hospital stays was significantly shorter in the TXA group (MD = −0.67; 95% CI, −1.12 to −0.23; p = 0.003). In terms of thromboembolic events, there was no significant differences between the TXA group and control group in deep vein thrombosis, pulmonary embolism, myocardial infarction, and ischemic stroke. As for complications and mortality, there was no significant differences between the TXA group and control group in respiratory infection, renal failure, and postoperative mortality within 1 year.Conclusion: TXA is an effective and safe drug for perioperative bleeding control in intertrochanteric fracture patients treated with intramedullary fixation. However, the long-term efficacy of TXA still needs to be investigated by large-scale multicenter randomized controlled trials.Level of evidence: II, Systematic review and Meta-analysis.Systematic Review Registration:https://inplasy.com/, identifier [INPLASY202280027]
Y la guerra entró en los hogares: noventa años de propaganda y fotografía bélica (1855-1945)
Authors: López Torán José Manuel 
Published: September 2022

La presente investigación, construida sobre abundante documentación gráfica, ofrece una reflexión acerca de la evolución que experimentó la fotografía en conflictos bélicos librados desde la guerra de Crimea hasta la Segunda Guerra Mundial. Para ello, se analiza la utilización que tuvo este recurso visual dentro de la propaganda en las respectivas contiendas, un campo de estudio que en los últimos años ha recibido una considerable atención, pero que carece de la sistematización que precisa. De esta manera, los objetivos que se plantean son contribuir a llenar ese vacío detectado, así como proporcionar una serie de recursos digitales a futuras investigaciones sobre un tipo de material caracterizado por su notable dispersión.
Para llevar a cabo el análisis, y dotarlo del carácter transnacional que requiere, se ha recurrido a documentación custodiada en instituciones de Alemania y Francia, así como a importantes fondos digitalizados pertenecientes a centros de investigación estadounidenses, españoles y británicos.
METHODOLOGICAL APPROACHES TO MANAGEMENT AND TECHNOLOGY FOR DEVELOPING AN EFFECTIVE STRATEGY FOR THE DEVELOPMENT OF REGIONAL UNIVERSITIES
Authors: Тавбулатова З. К. , Чаплаев Х. Г. 
Published: September 2022

В данной статье приведены результаты исследований приоритетных задач развития регионального университета с точки зрения внедрения новых технологий в сфере стратегического менеджмента в управлении образовательной организацией и выработки эффективных стратегий развития региональных вузов. Авторами статьи рассматривается стратегический менеджмент образовательной организации на современном этапе, затрагиваются проблемы системы государственной регламентации и национальной системы аккредитации высшего образования в образовательной деятельности, рассматривается вопрос утверждения национальной рамки квалификаций и закрепления национальной системы квалификаций.
This article presents the results of research on the priority tasks of the development of a regional university in terms of the introduction of new technologies in the field of strategic management in the management of an educational organization and the development of effective strategies for the development of regional universities.An attempt is made to conceptually develop a model of an effective contract as a functional tool for managingthestrategicdevelopmentoftheuniversityintheconditionsoftransformationaltransformations. The obtained results are formed on the basis of the adaptation of the methodology of the balanced scorecard and key performance indicators to the specifics of management systems for the development of educational organizations; decomposition of the priority goals and objectives of the development of educational organizations in the terminology of classical management theory and modern management concepts of educational organizations, as well as on the basis of determining the target functional blocks of an effective contract aimed at activating the resource potential of educational organizations