bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infantile Hypertrophic Pyloric Stenosis, the Cause of Non-bilious Vomiting of a 3-day-old Male Infant with Situs Inversus Totalis; A Case Report
Authors: Khanghah Ali Samady , Atqiaee Khashayar , Tabatabaey Ali 
Published: April 2022

Abstract
Background: The Synchronicity of Situs Inversus totalis (SIT) and infantile hypertrophic pyloric stenosis (IHPS) is a rare phenomenon with only 2 reported cases in the literature. SIT is a mirror transposition of the major visceral organs, arranged along a left-right axis. Its prevalence is 0.1—0.6 per 10,000 live births. Rarely it is accompanied by neonatal intestinal obstruction, congenital heart defects, primary ciliary dyskinesia, renal disorders, biliary atresia, skeletal dysplasia, and mental retardation. IHPS is muscular hypertrophy of the pylorus, which results in gastric outlet obstruction leading to post-feeding non-bilious projectile vomiting. Its common age of involvement is three weeks to 3 months and is rarely reported in newborns. Case presentation: We have reported a case of synchronous SIT and IHPS in a 3-day-old newborn with classic symptoms. Following hemodynamic resuscitation, he underwent pyloromyotomy. The recovery and follow-up periods were uneventful, and the child's growth has resumed naturally.Conclusions: We present a patient with two extremely rare disorders leading to gastric outlet stenosis. In a newborn, even non-bilious vomiting can be a sign of a serious underlying condition and demands careful evaluation.
Behaviour Regulation, Locus of Control and the Role of Mental Health in Non-alcoholic Fatty Liver Disease
Authors: Asquith Emily , Bould Kiah , Catling Jon , Day Ed , Holt Andrew 
Published: April 2022

Abstract
Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in wealthy societies, and if left untreated can become life-threatening. Current treatments prioritise diet and exercise management but patients frequently fail to make the necessary lifestyle changes. The current study aimed to identify factors which may influence patients’ behaviour in respect to adherence to treatment regimes. Methods: Novel areas of interest were investigated; locus of control, Behavioural regulation and a range of mental health measures, due to their links to either poor lifestyle choices or abnormal eating as identified in previous literature. Data was gathered using self-report questionnaires, from 96 participants, who were split into three groups, NAFLD patients, non-lifestyle liver disease patients and healthy controls, Results: Data was analysed using a MANOVA, and followed up with a Tukey post-hoc test. Three factors were found to be significant by group; cognitive restraint, uncontrolled eating and SAPAS score (measure of personality disorders). An association between personality disorders and NAFLD was identified Conclusion: it is suggested that NAFLD patients are screened for personality disorders and, if identified, treated prior to the commencement of diet and exercise management.
Effect of Autologous Bone Marrow Derived Mesenchymal Stem Cells in Treatment of Rheumatoid Arthritis
Authors: Elbasha Yara Ibrahim , Mesbah Noha M. , Abdel-Hamed Asmaa R. , Aboelmaaty Dina M. , Bakry Sayed , Mansour Ahmad , Elbeialy Adel 
Published: April 2022

Abstract
Introduction: Chronic inflammation causes articular bone and cartilage degeneration in people with rheumatoid arthritis (RA). Despite recent advancements in the management of RA, adverse side effects and ineffective treatments remain a problem. Access to treatment is hampered by financial restrictions. As a result, medications that reduce inflammation and bone resorption that are both safe and less expensive are required. Mesenchymal stem cells (MSCs) have recently been identified as a potential therapy for RA. Aim of study: The aim of this study was to examine the anti-arthritic effect of rat bone marrow-MSCs, oligosaccharides and human placental extract, individually and combined on RA model, using Complete Freund's adjuvant (CFA) induced arthritis in rats. Materials and methods: In female rats, RA was induced by injecting CFA in the paw of hind limb. Rat bone marrow-MSCs, oligosaccharides, and human placental extract (HPE) were given individually and in combination via intra-peritoneal route. Complete blood picture (CBC), erythrocyte sedimentation rate (ESR), serum cortisol, urea, uric acid and other biochemical parameters were measured to determine the safety and efficacy of the different treatments. Histopathological analysis of bone sections was carried out.Result: Combining oligosaccharides and HPE with rat-bone marrow MSCs had a favorable anti-arthritic and anti-inflammatory effect in CFA-induced arthritis in rats, with no negative effects on CBC, renal functions, serum cortisol, ESR, and liver enzymes. Histopathological analysis showed healing and remodeling of osteoporotic lesions in arthritic rats. Conclusion: Combination of rat MSCs, oligosaccharides and HPE has potential to be an effective treatment for rheumatoid arthritis.
A regularized Trefftz method for solving an inverse problem for the Laplace equation
Authors: Hadj Abdelhak , Saker Hacene 
Published: April 2022

Abstract
The present paper proposes a new regularized Trefftz method to recover the boundary value on a non-accessible boundary of an annulus from over determined data on the accessible boundary of that annulus. Considering that the available data have a Fourier expansion, we consider the Tikhonov damping factor in constructing our regularized scheme, which satisfies the boundary value problem. At the same time, the convergence estimates for the regularized solution will be established under an assumption for the exact solution. The finite term truncation of the series expansion allows us to match the boundary condition as accurately as desired. By the collocation method, we derive a system of linear equations that can be uniquely solved to obtain the coefficients and preset the regularization parameter and the damping factor to ensure adequate stability. The numerical efficiency of the proposed method is investigated with a high truncation number in comparison with the modified collocation Trefftz method.
Detection and isolation of a new member of Burkholderiaceae-related endofungal bacteria from a new thermophilic species in Mucorales
Authors: Takashima Yusuke , Yamamoto Kohei , Degawa Yousuke , Guo Yong , Nishizawa Tomoyasu , Ohta Hiroyuki , Narisawa Kazuhiko 
Published: April 2022

Abstract
Thermophilic fungi in Mucorales (Mucoromycotina) have the potential to be opportunistic pathogens, causing mucormycosis. Among them, Burkholderiaceae-related endobacteria (BRE) are rarely found and the known range of hosts is limited to Rhizopus spp. The phylogenetic divergence of BRE has recently expanded in other fungal groups such as Mortierella spp. (Mortierellomycotina); however, it remains unexplored in Mucorales. Here, we found a thermophilic mucoralean fungus obtained from a litter sample collected from Haha-jima Island in the Ogasawara (Bonin) Islands, Japan. The fungus was morphologically, phylogenetically, and physiologically characterized and proposed as a new species, Saksenaea boninensis sp. nov. Besides the fungal taxonomy, we also found the presence of BRE in isolates of this species by diagnostic PCR amplification of the 16S rRNA gene from mycelia, fluorescence microscopic observations, and isolation of the bacterium in pure culture. Phylogenetic analysis of the 16S rRNA gene of BRE revealed that it is distinct from all known BRE. The discovery of a culturable BRE lineage in the genus Saksenaea will add new insight into the evolutional origin of mucoralean fungus-BRE associations and emphasize the need to pay more attention to endofungal bacteria potentially associated with isolates of thermophilic mucoralean fungi causing mucormycosis.
Does foreign direct investment asymmetrically influence carbon emissions in sub-Saharan Africa? Evidence from nonlinear panel ARDL approach
Authors: Abdul-Mumuni Abdallah , Amoh John Kwaku , Mensah Barbara Deladem 
Published: April 2022

Abstract
While several existing panel studies have focused on the linear effect of foreign direct investment on carbon emissions, nonlinear panel studies on this subject remain thin on the ground. This paper examines the asymmetric effect of foreign direct investment on carbon emissions in 41 selected sub-Saharan African countries spanning from 1996 to 2018. In order to decompose foreign direct investment into positive and negative partial sum and examine possible asymmetric effects of the variables on carbon emissions, we used the nonlinear panel ARDL approach. This method accounts for cross-sectional variances that cause inherent heterogeneity in the slope coefficients. Our results show that carbon emissions respond asymmetrically to changes in foreign direct investment. The results further show that in the long run, a positive shock in foreign direct investment increases carbon emissions while a negative shock lowers them. It is recommended that comprehensive investment policies aimed at encouraging aimed clean technology and environmentally-friendly investments be implemented to ensure environmental sustainability.
Can environmental protection policies promote regional innovation efficiency: A difference-in-differences approach with continuous treatment
Authors: Zhang Jianqing , Tang Hengyun , Bao Minjun 
Published: April 2022

Abstract
Environmental regulation and innovative development are essential means to solve the negative externalities of environmental pollution. However, developing countries often face the dual pressures of environmental pollution and innovative development. This paper focuses on whether environmental protection policies (EPP) can achieve a win-win situation between green development and innovative development. Based on the panel data of 277 cities in China from 2006 to 2016, this paper studies the impact of China's EPP on urban innovation efficiency by using a time-varying difference-in-differences approach. Combined with the geographical features of Chinese cities, we further take urban form into the mediating effect analysis. The results show that: (1) EPP has a significant positive impact on innovation efficiency, and the result satisfies the parallel trend test. (2) The robustness test shows that EPP has technological innovation and diffusion effects. (3) The mediating effect test show that Urban form has a significant mediating effect on the impact of EPP on innovation efficiency. Therefore, environmental policies should be formulated considering the differences of urban form to achieve the optimal implementation effect.
The effect of omeprazole on urinary excretion of magnesium in children with peptic diseases
Authors: Famouri Fatemeh , Tavahen Nirvana , Gholami Hossein , Yazdi Maryam , Beni Motahar Heidari- 
Published: April 2022

Abstract
Purpose: This study aimed to assess the effect of omeprazole on urinary excretion of magnesium in children receiving omeprazole for treatment of peptic disease. What is the effect of omeprazole on urinary fractional excretion of magnesium? Methods: This single-armed clinical trial study was conducted on 44 children with a diagnosis of acid peptic disease who was treated with omeprazole (1-2 mg/kg/day) for 3 months in Gastroenterology clinics of Imam Hossein hospital, 2021, Isfahan, Iran. Before and after the intervention, serum levels of magnesium and creatinine and urine magnesium and creatinine levels were measured by Pars Azmoon Kit based on the guideline of the kit. Then fractional excretion of magnesium (Mg) was calculated based on the formula. Results: The mean urinary magnesium levels before and after intervention were 4.96±2.48 and 1.46±0.63, respectively (P<0.001). A significant decrease in serum Mg level was also observed after treatment versus before treatment (1.37±0.03 vs. 1.9±0.2, P<0.01). The mean fractional Mg excretion before and after therapy were 5.2±1.2 and 1.7±0.63, respectively (P<0.01). Serum creatinine level before and after therapy was 0.62±0.19 and 0.67±0.13, respectively (p=0.053). Urinary creatinine level was increased after intervention by 20.80±18.77 (p<0.001). Conclusion: The cause of hypomagnesemia is not increased urinary loss of magnesium, conversely, the kidney effort to compensate for the drop in blood magnesium following omeprazole treatment, by reducing urinary excretion of it and saving magnesium ions in the body.
A new epidemic profile for human scabies in a general practice in the city of Tourcoing, northern France
Authors: Grujon Anaëlle , Quindroit Paul , Legrand Bertrand , Calafiore Matthieu , Rochoy Michaël , Staumont-Sallé Delphine , Beuscart Jean-Baptiste , Chazard Emmanuel 
Published: April 2022

Abstract
Background: Scabies is a public health problem. In France, this disease accounts for several hundred million consultations in primary care each year. The objectives of the present study (with reuse of data collected routinely in primary care) were to estimate the incidence of scabies in a general practice and to describe the corresponding patient population.Methods: From January 2013 to June 2015, we conducted a real-life study of consultation data from a general practice in the Lille urban area of northern France. We estimated the incidence of scabies in the area, searched for factors that might influence disease occurrence and recurrence, and looked at how patients with scabies were managed.Results: The study included 177 patients (96 women). The incidence of scabies was similar in males and females. The infection was more common in early childhood (regardless of the sex) and in women aged 40-50. Scabies occurred more frequently during the colder months (e.g. 12.4% of all cases were recorded in January). We did not observe any significant associations between scabies and immune conditions or pre-existing comorbidities. All patients received scabicides: 163 received a systemic treatment only (ivermectin), 10 received a local treatment only (8 for benzyl benzoate and 2 for piperonyl butoxide with esdepallethrine), and 3 received both systemic and local treatments. Scabies recurred in 42 patients (23.7%; within 60 days in 16 cases (9.04%)). The median [1st & 3rd quartiles] time interval between diagnosis and recurrence was 28 days [22.3; 36.3]. The recurrence rate appeared to be significantly higher in winter than in other seasons: 68.8% of the recurrences occurred in the winter (p=0.021). Age did not appear to be a risk factor for recurrence (p=0.63).Conclusion: The present results show that scabies is now a common pathology in general practice and is most likely to affect children and young adults in urban areas. The age and sex distributions usually described are no longer relevant. Our results also emphasize the value of reusing data collected routinely data in primary care, which can open up exciting fields in medical research.
Genomic Characteristics of a Klebsiella pneumoniae Strain Coproducing Carbapenemases KPC-2 and NDM-5
Authors: Xiao Wei-qiang , Qu Yuan-ye , Wang Xiao-kun , Sun Ming-yue , Chang Yan-min , Xu Qing-xia 
Published: April 2022

Abstract
The aim of this study was to characterize the resistance gene of a Klebsiella pneumoniae strain coproducing carbapenemases KPC-2 and NDM-5.Klebsiella pneumoniae KPN-hnqyy, which is separated from the stool specimen of a patient, is resistant to all carbapenem antibiotics. Its MLST type is ST11. The genes of carbapenemases blaKPC-2 and blaNDM-5 are positive. The gene of conjugant blaKPC-2 is positive and that of conjugant blaNDM-5 is negative. Whole-genome sequencing shows that the strain contains one chromosome and three plasmids. The chromosome genomes of Klebsiella pneumonia such as KP69 and KP19-2029 are more than 99.9% similar to the chromosome genome of the strain studied; also, a similar IncR and IncFII resistance gene fusion region is contained in the different types of plasmids they carry: the blaKPC-2 gene is located in a structure—which evolved from the Tn3-△Tn4401-Tn1721/Tn1722 sequence—inside this fusion region with its ends inserted into the transposase IS26 gene; the blaNDM-5 gene is located on an I-shaped transposon containing the special plasmids of the insertion fragment in phages, with its ends inserted into the transposase IS26 gene, too.The Klebsiella pneumoniae KPN-hnqyy that carries both blaKPC-2 and blaNDM-5 may be derived from the blaKPC-2 carrying Klebsiella pneumoniae KP69 and KP19-2029 strains accidentally obtain the blaNDM-5 gene by the transfer of IS26 transposable elements. The wide transmission of Klebsiella pneumoniae ST11 carrying the blaKPC-2 gene in China and its ability to obtain other carbapenemase genes through transposable element IS26 are well worth attention.
Predict the Risk of Dyslipidemia via Deep Neural Networks for Survival Data
Authors: Liang Hailun , Liang Dongzuo , Tao Lei , Zhang Xiaoshuai , Li Xiao , Zheng Da , Chen Yuhan , Yi Meixi , Tang Fang 
Published: April 2022

Abstract
Background: Dyslipidemia is an important risk factor for coronary artery disease and stroke. Early detection and prevention of dyslipidemia can markedly alter cardiovascular morbidity and mortality. Cox proportional hazard model has been commonly employed for survival datasets to construct the prediction model. Recently, the data-driven learning algorithm began to be used to analyze right-censored survival data. However, there is no attempt to use deep neural networks in dyslipidemia prediction. The objective of this study is to predict the risk of dyslipidemia via deep neural networks for survival data.Methods: The study cohort was based on the routine health check-up data from 6,328 participants aged 19 to 90 years and free of dyslipidemia at baseline. A deep neural network (DNN) was used to develop risk models for predicting dyslipidemia. Cox Proportional Hazards (Cox) and Random Survival Forests (RSF) were applied in comparison with the DNN model. As our metric of performance, we use the time-dependent concordance index (Ctd-index).Results: The Ctd-index of the prediction models by using DNN was 0.802. The DNN model performed significantly better than Cox and RSF model (Ctd-index: 0.735 and 0.770, respectively). The improvement of DNN over the competing methods was statistically significant. Moreover, DNN provides performance gain on time intervals compared to conventional survival models.Conclusions: DNN is a promising method in learning the estimated distribution of survival time and event while capturing the right-censored nature inherent in survival data. DNN achieves large and statistically significant performance improvements over previous intuitive regression model and state-of-the-art data-mining methods.
High endothelial venules in intracranial germinomas: implications for lymphocytes infiltration
Authors: Chen Huiyuan , Li Guilin , Cui Yun , Zhang Qi , Li Bo , Liu Xing 
Published: April 2022

Abstract
Background
Reactive lymphocytes are substantial components of germinoma, which are believed to be related to the favorable prognosis of this intracranial tumor and better response to immunotherapy. However, the mechanisms managing the recruitment of lymphocytes are poorly understood. High endothelial venules (HEVs) are specialized blood vessels that play key roles in lymphocyte trafficking in Lymph nodes. These vessels are associated with lymphocytes infiltration in chronic inflammatory diseases and various malignant tumors, but their distribution and implications in germinoma are unknown.
Methods
This study investigated the presence and distribution of HEVs in 42 germinomas by immunohistochemical staining of peripheral node addressin (PNAd) and transmission electron microscopic examination. The correlation of the densities of HEVs with the extent of T and B lymphocytes infiltration and several clinicopathological characteristics were also analyzed to determine whether HEVs are responsible for lymphocytes recruitment and their roles in anti-tumor immunity in germinoma.
Results
PNAd-positive HEVs were detected in 31% (13/42) of germinomas, and their presence correlated with abundant infiltrating CD3 + T cells, CD20 + B cells and CD8 + Cytotoxic T Lymphocytes (p = 0.0410, 0.0023, 0.0061, respectively). Higher HEVs density was also correlated with several clinicopathological parameters, which are recognized indicators for favorable prognosis in germinomas, including typical tumor location (p = 0.0093), lower tumor cell content (P = 0.0428), and younger age at diagnosis (p = 0.0121). Furthermore, bioinformatics analysis showed HEVs-associated genes mainly enriched in immune-related Gene Ontology terms, including innate immune response, inflammatory response, and B cell receptor signaling pathway. The xCell analysis revealed that germinomas with higher HEVs enrichment scores had increased levels of the immune score, microenvironment score, dendritic cells, CD8 + central memory T-cells, CD4 + memory T-cells, and B-cells.
Conclusion
Our findings indicate that HEVs could contribute to lymphocytes recruitment in germinomas, thus may serve as a predictor of favorable prognosis and better response to immunotherapy in this intracranial tumor.
Risk Factors and Resilience Associated to Depressive Symptoms in Mexican Healthcare Workers During the Early Stages of the Covid-19 Pandemic
Authors: Borges Guilherme , Arias Sol Durand , Carmona-Huerta Jaime , Aldana-López Alejandro , Náfate-López Omar , Orozco Ricardo , Cordoba Gloria , Alvarado Rubén 
Published: April 2022

Abstract
IntroductionThe world has been marked by the global COVID-19 pandemic, which has had an impact in everyone’s lives, but particularly in healthcare workers (HCW), whom have been exposed to higher workload, COVID exposure and stigma, all of which are known risk factors for mental health problems.ObjectiveThe aim of this study is to report the prevalence of depression, risk factors and resilience related to the initial phase of the COVID-19 pandemic among Mexican HCW.Method This is an observational cross-sectional study part of a larger international, prospective multicentric study “The COVID-19 HEalth caRe wOrkErs Study” (HEROES). A convenience sample with a total of 2,127 HCW from two states of Mexico (Chiapas and Jalisco) were recruited. Depression was the main outcome, assessed using the Patient Health Questionnaire (PHQ-9). A COVID-19 risk scale was developed with a total of 19 items. Resilience was studied with the Brief Resilience Scale (BRS). Model-adjusted prevalence ratios (PRs) were estimated.ResultsWe found moderate to severe depression in 16.6% of the study sample. HCW from Jalisco, medical staff, working in hospitals, and those with chronic illness and with a mental health history were more depressed. Regarding the COVID-19 related risk factors, we found more than double the prevalence of depression (2.14, 95%CI=1.64-2.8) for those exposed to ≥8 of the risk variables here studied. Depression was prevalent in 30% of HCW with low resilience, 13.3% with medium resilience and only 4.4% of those with high resilience. Discussion and conclusionCOVID-19 related risk factors increase the prevalence of depression in HCW, whereas resilience proved to be a protective factor (higher resilience, less prevalence of depression). This evidence proves the need to develop strategies to reduce the risk (developing measures to enhance trust in the workplace and anti-sigma campaigns) and enhance resilience (fostering wellness and building relationships) in HCW. Clinical Trial Registration: The COVID-19 HEalth caRe wOrkErs (HEROES). Study. Identifier: NCT04352634