bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of lymphocyte immunotherapy in the treatment of recurrent pregnancy loss from alloimmunity: A systematic review and meta‐analysis
Authors: Francisco Phorenice D. , Tan‐Lim Carol Stephanie C. , Agcaoili‐De Jesus Maria Socorro L. 
Published: July 2022

AbstractProblemThe efficacy of lymphocyte immunotherapy (LIT) in the treatment of recurrent pregnancy loss (RPL) from alloimmunity has been debated for years. There is conflicting evidence on the therapeutic role of LIT, since the etiology of most cases of RPL is previously classified as idiopathic.Method of studyA systematic search of PubMed and Cochrane databases was done for randomized controlled trials that assessed the efficacy of paternal lymphocyte or third donor LIT among patients with primary or secondary RPL. The primary outcome was live birth rate after LIT. Random‐effect meta‐analysis was conducted using the software RevMan 5.4. Pre‐planned subgroup analyses of source of lymphocytes, timing and frequency of administration, and concentration per immunization dose were conducted.ResultsData from eight trials showed a statistically significant benefit of LIT (RR = 1.45, 95% CI 1.05‐2.01). The overall live birth rate is higher in the treatment group (65.6%) compared to placebo or no treatment (45.2%). Subgroup analysis based on source of lymphocytes revealed a trend towards benefit with paternal LIT but with wide confidence interval (RR = 1.34, 95% CI = .84‐2.14). Multiple doses of immunotherapy before pregnancy and low dose (5×106 cells) LIT showed significant benefit. Sensitivity analysis involving studies with a low risk of bias demonstrated significant benefit of increased live birth rate among patients treated with LIT compared to those who received placebo or no treatment (RR = 1.97, 95% CI = 1.53‐2.53).ConclusionLIT demonstrate benefit in improving pregnancy outcome of patients with RPL from alloimmunity.
A mixed‐methods evaluation of a health‐promoting café located in a small health service in rural Victoria, Australia
Authors: Whelan Jillian , Love Penelope , Aitken John , Millar Lynne , Morley Catherine , Melgren Ngareta , Allender Steven , Bell Colin 
Published: July 2022

AbstractIntroductionResidents of rural areas internationally typically experience chronic disease risk profiles worse than city dwellers. Poor diet, a key driver of chronic disease, has been associated with unhealthy food environments, and rural areas often experience limited access to healthy, fresh and affordable food.ObjectiveThis study aimed to evaluate the first three years of a health promoting social enterprise café established in a small rural health service.DesignA mixed‐methods evaluation study. Quantitative sales data, surveys and key informant interviews that included both quantitative and qualitative responses.FindingsThree years of sales data were included; 111customer surveys and five key informant interviews were conducted. Food and beverages on displayed and sold consistently met or exceeded the healthy criteria set by policy. Stakeholders supported the traffic light system, the social enterprise model and rated the likelihood of sustainability of the café as high.DiscussionCustomers used the ‘traffic light’ system to inform food choices, placed value on the warmth of the staff and on the welcoming environment created through the social enterprise model. Resources remain tight although all stakeholders are committed to the sustainability of the YarriYak café.ConclusionThe study shows the acceptability, feasibility and sustainability of a health promoting social enterprise café in a rural area.
Learning to self‐lead: Examining self‐leadership strategies, personality traits and learning attainment
Authors: Woods Stephen A. , Napiersky Uwe , Rivkin Wladislaw 
Published: July 2022

AbstractThis study examined self‐leadership, an integrative concept in organisational behaviour and psychology, that represents a person's ability to manage themselves and improve their own performance through a combination of behavioural, cognitive and motivational strategies, in the context of learning and development outcomes. Change in three aspects of self‐leadership (termed the Doing‐self, Thinking‐self and Energising‐self) following a short development intervention was examined in a sample of management school students in a pre‐intervention and postintervention design. The study also expanded upon the role of personality traits in moderating self‐leadership change. The data additionally provide evidence of the association of self‐leadership with learning attainment. The findings of this study underline the potential benefits of self‐leadership learning and development. Implications for theory and practice in organisations are discussed.
International cooperation during COVID‐19: Case study vaccine cooperation and its impact in Indonesia
Authors: Pratiwi Fadhila Inas , Muttaqien M. , Samy Muhammad , Fadli Jilan Hanifah , Intan Angelique Angie , Kusuma Nugraha Ryadi 
Published: July 2022

AbstractThis policy review analyzes the international cooperation experienced in Indonesia during the COVID‐19 pandemic, specifically concerning vaccine cooperation. It examines the policy debates of vaccine cooperation within Indonesia from the government, parliament, religious organizations, civil society, and mass media. Although some feel pessimistic about vaccine cooperation, the results found that vaccine cooperation has a positive impact on Indonesia. This is because gradually after the highest COVID‐19 cases in July 2021, the government continued to increase the vaccination rate and by the end of September 2021, Indonesia finally reached the lowest case numbers. Therefore, the vaccine cooperation between Indonesia and other countries proved to be effective in reducing the COVID‐19 cases in Indonesia. International cooperation is necessary in times of crisis.
Primary nonadherence to drugs prescribed by general practitioners: A Dutch database study
Authors: Hempenius Mirjam , Rijken Simone , Groenwold Rolf H. H. , Hek Karin , de Boer Anthonius , Klungel Olaf H. , Gardarsdottir Helga 
Published: July 2022

AimPrimary nonadherence (PNA) is defined as not filling the first prescription for a drug treatment. PNA can lead not only to poor patient outcomes but also to exposure misclassification in written prescription databases. This study aims to estimate PNA in primary care in the Netherlands and to investigate associated factors.MethodsPatients from the Nivel Primary Care Database (Nivel‐PCD) who received a new prescription (>1 year not prescribed) from a general practitioner in 2012 were linked to pharmacy dispensing information of consenting pharmacies based on sex, year of birth, four‐digit postal code and at least 50% matching Anatomical Therapeutic Classification codes. PNA was defined as not having a prescription dispensed within 30 days from the prescribing date. PNA was assessed overall and per drug class. The associations between PNA and several patient‐ and prescription‐related characteristics were assessed using mixed‐effects logistic regression models.ResultsAfter matching 86 361 of 396 251 subjects (21.8%) in the Nivel‐PCD records to the pharmacy records, this study included 65 877 subjects who received 181 939 new drug prescriptions. Overall, PNA was 11.5%. PNA was lowest for thyroid hormones (5.5%) and highest for proton pump inhibitors (12.8%). Several factors were associated with PNA, such as having comorbidities (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.37‐1.56 for >3 active diagnoses, compared to no active diagnoses) or reimbursement status (OR 2.78, 95% CI 2.65‐2.92 for not reimbursed drugs compared to fully reimbursed drugs).ConclusionsA total of 11.5% of newly prescribed drugs were not dispensed. This can lead to overestimation of the actual drug exposure status when using written prescription databases.
Center-Augmented ℓ2-Type Regularization for Subgroup Learning
Authors: He Ye , Zhou Ling , Xia Yingcun , Lin Huazhen 
Published: July 2022

Abstract
The existing methods for subgroup analysis can be roughly divided into two categories: finite mixture models (FMM) and regularization methods with an ℓ1-type penalty. In this paper, by introducing the group centers and ℓ2-type penalty in the loss function, we propose a novel center-augmented regularization (CAR) method; this method can be regarded as a unification of the regularization method and FMM and hence exhibits higher efficiency and robustness and simpler computations than the existing methods. In particular, its computational complexity is reduced from the of the conventional pairwise-penalty method to only , where n is the sample size and K is the number of subgroups. The asymptotic normality of CAR is established, and the convergence of the algorithm is proven. CAR is applied to a dataset from a multicenter clinical trial, Buprenorphine in the Treatment of Opiate Dependence; a larger R2 is produced and three additional significant variables are identified compared to those of the existing methods.
Real-world data on the effectiveness, safety and drug survival of dupilumab: an analysis from the TREATgermany registry
Authors: Stölzl Dora , Sander Nicole , Heratizadeh Annice , Haufe Eva , Harder Inken , Abraham Susanne , Heinrich Luise , Kleinheinz Andreas , Wollenberg Andreas , Weisshaar Elke , Schäkel Knut , Ertner Konstantin , Wiemers Franca , Wildberger Julia , Worm Margitta , von Kiedrowski Ralph , Effendy Isaak , Asmussen Andrea , Augustin Matthias , Pawlak Mario , Sticherling Michael , Zink Alexander , Hilgers Melanie , Handrick Christiane , Quist Sven , Schwarz Beate , Staubach-Renz Petra , Bell Magnus , Hong-Weldemann Sun-Hei , Homey Bernhard , Brücher Jens-Joachim , Schmitt Jochen , Werfel Thomas , Weidinger Stephan ,   the TREATgermany study group
Published: July 2022

Abstract
This interim analysis from the atopic dermatitis registry TREATgermany shows robust long-term efficacy, favourable safety and high persistence of dupilumab under real life conditions.
Complete responses to odronextamab in two patients with diffuse large B‐cell lymphoma refractory to chimeric antigen receptor T‐cell therapy
Authors: Weinstock Matt , Elavalakanar Pavania , Bright Susan , Ambati Srikanth R. , Brouwer‐Visser Jurriaan , Pourpe Stephane , Fiaschi Nathalie , Jankovic Vladimir , Thurston Gavin , Deering Raquel P. , Chaudhry Aafia , Joyce Robin , Arnason Jon 
Published: July 2022

SummaryOutcomes remain poor for patients with relapsed/refractory B‐cell non‐Hodgkin lymphoma (R/R B‐NHL). While chimeric antigen receptor (CAR) T‐cell therapy has revolutionised treatment, a significant proportion of patients relapse or fail to respond. Odronextamab is a CD20 × CD3 bispecific antibody that has demonstrated durable responses and a manageable safety profile in patients with R/R B‐NHL in a first‐in‐human trial (NCT02290951). Here, we document two patients with diffuse large B‐cell lymphoma refractory to CART‐cell therapy. Both achieved complete responses that remain ongoing for ≥2 years following odronextamab. Neither patient experienced Grade ≥3 cytokine release syndrome or Grade ≥3 neurological adverse events during treatment.
Learning from the experience of parents in poverty: The power of recognition
Authors: Sanfelici Mara 
Published: July 2022

AbstractThis study aims to contribute to the literature exploring the parents' perspective on what parenting in poverty means in their everyday life and how they are able to cope with the challenges that arise from a condition of economic deprivation. Forty parents living in different Italian regions had been interviewed. Data gathering and data analysis were conducted as a simultaneous and iterative process, oriented by the constructivist grounded theory. Our findings provide a clear picture of the parents' constant struggle to protect their children from an environment in which structural conditions and dominant narratives lead to normalize and personalize disadvantages. Parents described enabling and disabling processes that interplay at a material, relational and symbolic level, influencing their movement along a continuum that depicts different experiences in different moments of their lives, as the output of processes where vulnerabilities and strengths are combined. The parents' knowledge helps to explain the wider social processes and the day‐to‐day social interactions that influence the flow along this continuum. The final purpose is to allow their voices to be heard and to learn from their perspective, as it is essential in designing policies and services that are supposed to help them.
Event‐based Dynamic Graph Drawing without the Agonizing Pain
Authors: Arleo A. , Miksch S. , Archambault D. 
Published: July 2022

AbstractTemporal networks can naturally model real‐world complex phenomena such as contact networks, information dissemination and physical proximity. However, nodes and edges bear real‐time coordinates, making it difficult to organize them into discrete timeslices, without a loss of temporal information due to projection. Event‐based dynamic graph drawing rejects the notion of a timeslice and allows each node and edge to retain its own real‐valued time coordinate. While existing work has demonstrated clear advantages for this approach, they come at a running time cost. We investigate the problem of accelerating event‐based layout to make it more competitive with existing layout techniques. In this paper, we describe the design, implementation and experimental evaluation of MultiDynNoS, the first multi‐level event‐based graph layout algorithm. We consider three operators for coarsening and placement, inspired by Walshaw, GRIP and FM3, which we couple with an event‐based graph drawing algorithm. We also propose two extensions to the core algorithm: AutoTau and Bend Transfer. We perform two experiments: first, we compare MultiDynNoS variants to existing state‐of‐the‐art dynamic graph layout approaches; second, we investigate the impact of each of the proposed algorithm extensions. MultiDynNoS proves to be competitive with existing approaches, and the proposed extensions achieve their design goals and contribute in opening new research directions.
Children's dimensions of poverty: Qualitative studies in urban China
Authors: Yang Lichao , Walker Robert , Zhang Guanli 
Published: July 2022

AbstractThe dimensionality of child poverty is not well understood because children are seldom asked systematically to describe their poverty experience. This hinders the prediction of poverty's long‐term consequences and constrains policy design. In this research, 55 children aged 8–12 from Hangzhou and Beijing China were each interviewed individually for 0.5–2 h and participated in 3–4 focus group sessions on poverty experience. Integrating their understanding with the perspectives of parents and teachers suggests nine dimensions of poverty: four structural (material deprivation, limiting home environment, constrained education, restricted opportunities); three relational (violence, negative social relations, lack of confidence) and two core (shame, neglected agency).
Associations between social determinants of health and abdominal solid organ transplant wait‐lists in the United States
Authors: Johnson Wali R. , Rega Scott A. , Feurer Irene D. , Karp Seth J. 
Published: July 2022

AbstractBackgroundSocietal factors that influence wait‐listing for transplantation are complex and poorly understood. Social determinants of health (SDOH) affect rates of and outcomes after transplantation.MethodsThis cross‐sectional study investigated the impact of SDOH on additions to state‐level, 2017–2018 kidney and liver wait‐lists. Principal components analysis, starting with 127 variables among 3142 counties, was used to derive novel, comprehensive state‐level composites, designated (1) health/economics and (2) community capital/urbanicity. Stepwise multivariate linear regression with backwards elimination (n = 51; 50 states and DC) tested the effects of these composites, Medicaid expansion, and center density on adult disease burden‐adjusted wait‐list additions.ResultsSDOH related to increased community capital/urbanicity were independently associated with wait‐listing (starting models: B = .40, P = .010 Kidney; B = .36, P = .038 Liver) (final models: B = .31, P = .027 Kidney, B = .34, P = .015 Liver). In contrast and surprisingly, no other covariates were associated with wait‐listing (P ≥ .122).ConclusionsThese results suggest that deficits in community resources are important contributors to disparities in wait‐list access. Our composite SDOH metrics may help identify at‐risk communities, which can be the focus of local and national policy initiatives to improve access to organ transplantation.
Levels of donor‐derived cell‐free DNA and chemokines in BK polyomavirus‐associated nephropathy
Authors: Mayer Katharina A. , Omic Haris , Weseslindtner Lukas , Doberer Konstantin , Reindl‐Schwaighofer Roman , Viard Thierry , Tillgren Amanda , Haindl Susanne , Casas Silvia , Eskandary Farsad , Heinzel Andreas , Kozakowski Nicolas , Kikić Željko , Böhmig Georg A. , Eder Michael 
Published: July 2022

AbstractBackgroundBK polyomavirus‐associated nephropathy (BKPyVAN) carries a risk of irreversible allograft injury. While detection of BK viremia and biopsy assessment are the current diagnostic gold standard, the diagnostic value of biomarkers reflecting tissue injury (donor‐derived cell‐free DNA [dd‐cfDNA]) or immune activation (C‐X‐C motif chemokine ligand [CXCL]9 and CXCL10) remains poorly defined.MethodsFor this retrospective study, 19 cases of BKPyVAN were selected from the Vienna transplant cohort (biopsies performed between 2012 and 2019). Eight patients with T cell‐mediated rejection (TCMR), 17 with antibody‐mediated rejection (ABMR) and 10 patients without polyomavirus nephropathy or rejection served as controls. Fractions of dd‐cfDNA were quantified using next‐generation sequencing and CXCL9 and CXCL10 were detected using multiplex immunoassays.ResultsBKPyVAN was associated with a slight increase in dd‐cfDNA (median; interquartile range: .38% [.27%‐1.2%] vs. .21% [.12%‐.34%] in non‐rejecting control patients; p = .005). Levels were far lower than in ABMR (1.2% [.82%‐2.5%]; p = .004]), but not different from TCMR (.54% [.26%‐3.56%]; p = .52). Within the BKPyVAN cohort, we found no relationship between dd‐cfDNA levels and the extent of tubulo‐interstitial infiltrates, BKPyVAN class and BK viremia/viruria, respectively. In some contrast to dd‐cfDNA, concentrations of urinary CXCL9 and CXCL10 exceeded those detected in ABMR, but similar increases were also found in TCMR.ConclusionBKPyVAN can induce moderate increases in dd‐cfDNA and concomitant high urinary excretion of chemokines, but this pattern may be indistinguishable from that of TCMR. Our results argue against a significant value of these biomarkers to reliably distinguish BKPyVAN from rejection.
Rapid bird species recovery following high‐severity wildfire but in the absence of early successional specialists
Authors: Lindenmayer David B. , Blanchard Wade , Bowd Elle , Scheele Ben C. , Foster Claire , Lavery Tyrone , McBurney Lachlan , Blair David 
Published: July 2022

AbstractAimThe distribution and abundance of forest biodiversity can be shaped by multiple drivers, including disturbances like wildfires. We quantified the influence of wildfire severity and bird life history attributes on temporal patterns of bird site occupancy.LocationWet eucalypt forests of Victoria, Australia.MethodsWe employed a Before, After, Control, Impact experimental design, gathering occupancy data on birds 5 years before, and for 10 years after, a wildfire in 2009. We quantified post‐fire decline and then recovery on sites subject to high‐severity fire, comparing these temporal patterns with those for birds at sites that were unburnt or burnt at moderate severity. We also tested the influence of life history attributes on bird responses to wildfire. Data were analysed using joint species distribution modelling, accounting for imperfect detection.ResultsWe found a two‐way interaction between fire severity and time period for overall bird site occupancy. The largest change between time periods was on sites burnt at high severity where bird occupancy declined immediately after fire followed by a strong recovery. Occupancy patterns remained largely unchanged on unburnt sites. For many individual species, interactions between fire severity and time period were similar to overall species occupancy. On sites subject to high‐severity fire, most species recovered to pre‐fire levels within 6 years. We found no evidence of a three‐way interaction between fire severity, time period, and life history attributes, with all trait groups of birds examined largely recovered to pre‐fire site occupancy levels 10 years post‐fire.Main conclusionsThe Victorian 2009 wildfires were severe, but their impacts on common bird species were relatively short‐lived, with immediate post‐fire declines mostly reversed within ~10 years. Rapid post‐fire stand regeneration appears a likely driver of these responses and may account for the relatively limited influence of life history attributes on bird species recovery. However, diet influenced bird species occupancy after fire, with nectivores recovering slower than insectivores on sites subject to high severity fire. Our findings may be relevant to other forests types globally where there can be rapid post‐fire vegetation growth and stand regeneration.
Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients
Authors: Dhaher Roni , Bronen Richard A. , Spencer Linda , Colic Lejla , Brown Franklin , Mian Ali , Sandhu Mani , Pittman Brian , Spencer Dennis , Blumberg Hilary P. , Altalib Hamada 
Published: July 2022

AbstractObjectiveTemporal lobe epilepsy (TLE) and depression are common comorbid disorders whose underlying shared neural network has yet to be determined. Although animal studies demonstrate a role for the dorsal bed nucleus of the stria terminalis (dBNST) in both seizures and depression, and human clinical studies demonstrate a therapeutic effect of stimulating this region on treatment‐resistant depression, the role of the dBNST in depressed and nondepressed TLE patients is still unclear. Here, we tested the hypothesis that this structure is morphologically abnormal in these epilepsy patients, with an increased abnormality in TLE patients with comorbid depression.MethodsIn this case‐controlled study, 3‐T structural magnetic resonance imaging scans were obtained from TLE patients with no depression (TLEonly), TLE patients with depression (TLEdep), and healthy control (HC) subjects. TLE subjects were recruited from the Yale University Comprehensive Epilepsy Center, diagnosed with the International League Against Epilepsy 2014 Diagnostic Guidelines, and confirmed by video‐electroencephalography. Diagnosis of major depressive disorder was confirmed by a trained neuropsychologist through a Mini International Neuropsychiatric Interview based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. The dBNST was delineated manually by reliable raters using Bioimage Suite software.ResultsThe number of patients and subjects included 35 TLEonly patients, 20 TLEdep patients, and 102 HC subjects. Both TLEonly and TLEdep patients had higher dBNST volumes compared to HC subjects, unilaterally in the left hemisphere in the TLEonly patients (p = .003) and bilaterally in the TLEdep patients (p < .0001). Furthermore, the TLEdep patients had a higher dBNST volume than the TLEonly patients in the right hemisphere (p = .02).SignificanceHere, we demonstrate an abnormality of the dBNST in TLE patients, both without depression (left enlargement) and with depression (bilateral enlargement). Our results demonstrate this region to underlie TLE both with and without depression, implicating it as a target in treating the comorbidity between these two disorders.