bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable Long‐Term and Wide‐Area Environment Monitoring Network Based on Distributed Self‐Powered Wireless Sensing Nodes
Authors: Liu Di , Li Chengyu , Chen Pengfei , Zhao Xin , Tang Wei , Wang Zhong Lin 
Published: November 2022

AbstractEnvironmental monitoring of local climatic variations plays a vital role in the research on global warming, species diversity, ecological sustainability, and so on. Traditional monitoring technologies, such as meteorological stations or satellite imagery, can give an overall environment picture but at high cost, high energy consumption, and with insufficient regional details. Here, a networking system made of low‐cost, maintenance‐free, and distributed self‐powered wireless monitoring nodes is proposed, aimed at establishing a sensing system for long‐term and wide‐area environment monitoring. It is demonstrated that, as driven by gentle wind, these distributed nodes are able to monitor temperature, humidity, and atmospheric pressure automatically, and then transfer the sensing data to receiving terminals wirelessly using triboelectric nanogenerators as energy harvesting technologies. The longest transmitting distance is 2.1 km. Additionally, a sensing network is formed. By utilizing several nodes, a 2‐km2 region is covered, and the information can be transmitted live using a relay‐technology. Furthermore, the node is demonstrated to work for weeks, and continuously send back environmental data. Since the nodes are portable and the embedded sensors are customizable, it is anticipated that the system can be multifunctional and applied in many natural areas, such as forests, prairies, mountains, lake regions, and so on.
A ring‐controlled fluorescent platform for visualizing polymer degradation
Authors: Wu Tianhong , Bian Wenhai , Wang Chunhui , Qiu Jie , Sun Xiaolong , Qian Xuhong 
Published: November 2022

AbstractThe creation of a new photoluminescent platform to study their photo physics and further applications is important in the fields of chemistry, material, physics, etc. In this work, we developed benzene‐based fluorophores generated by chemical reactions on conjugate acceptor precursors. Their optical properties have been studied, and the large Stokes shifts, high molar extinction coefficients and quantum yields have been revealed. The starting precursors containing bis‐intercalated vinyl thioester shows no luminescence, which is turned on by the chemically triggered cyclization. From spectroscopic, crystallographic, and computational studies, cyclization‐induced emission enhancement is proposed as a mean to explain the photoluminescent performances, a principle extended in the substituent incorporated fluorophores. Furthermore, they were applied to the chemically triggered degradation of a polymer and achieved visual tracking, quantifying, and downcycling of the processes. The method for designing and developing series fluorophores and visually tracking polymer degradation represents a new photoluminescent platform, allowing its further applications.
Simulated pollinator decline has similar effects on seed production of female and hermaphrodite Lobelia siphilitica, but different effects on selection on floral traits
Authors: Hossack Gavin C. , Caruso Christina M. 
Published: November 2022

AbstractPremisePollinator decline, by reducing seed production, is predicted to strengthen natural selection on floral traits. However, the effect of pollinator decline on gender dimorphic species (such as gynodioecious species, where plants produce female or hermaphrodite flowers) may differ between the sex morphs: if pollinator decline reduces the seed production of females more than hermaphrodites, then it should also have a larger effect on selection on floral traits in females than in hermaphrodites.MethodsTo simulate pollinator decline, we experimentally reduced pollinator access to female and hermaphrodite Lobelia siphilitica plants. We compared the seed production of plants in the reduced pollination treatment to plants that were exposed to ambient pollination conditions. Within each treatment, we also measured directional selection on four floral traits of females and hermaphrodites.ResultsExperimentally reducing pollination decreased seed production of both females and hermaphrodites by ~21%. Reducing pollination also strengthened selection on floral traits, but this effect was not larger in females than in hermaphrodites. Instead, reducing pollination intensified selection for taller inflorescences in hermaphrodites, but did not intensify selection on any floral trait in females.ConclusionsOur results suggest that pollinator decline will not have a larger effect on either seed production or selection on floral traits of female plants. As such, any effect of pollinator decline on seed production may be similar for gender dimorphic and monomorphic species. However, the potential for floral traits of females (and thus of gender dimorphic species) to evolve in response to pollinator decline may be limited.
Phylogeographic history of mitochondrial haplogroup J in Scandinavia
Authors: Kristjansson Dana , Schurr Theodore G. , Bohlin Jon , Jugessur Astanand 
Published: November 2022

AbstractBackgroundMitochondrial DNA haplogroup J is the third most frequent haplogroup in modern‐day Scandinavia, although it did not originate there. To infer the genetic history of haplogroup J in Scandinavia, we examined worldwide mitogenome sequences using a maximum‐likelihood phylogenetic approach.MethodsHaplogroup J mitogenome sequences were gathered from GenBank (n = 2245) and aligned against the ancestral Reconstructed Sapiens Reference Sequence. We also analyzed haplogroup J Viking Age sequences from the European Nucleotide Archive (n = 54). Genetic distances were estimated from these data and projected onto a maximum likelihood rooted phylogenetic tree to analyze clustering and branching dates.ResultsHaplogroup J originated approximately 42.6 kya (95% CI: 30.0–64.7), with several of its earliest branches being found within the Arabian Peninsula and Northern Africa. J1b was found most frequently in the Near East and Arabian Peninsula, while J1c occurred most frequently in Europe. Based on phylogenetic dating, subhaplogroup J1c has its early roots in the Mediterranean and Western Balkans. Otherwise, the majority of the branches found in Scandinavia are younger than those seen elsewhere, indicating that haplogroup J dispersed relatively recently into Northern Europe, most plausibly with Neolithic farmers.ConclusionsHaplogroup J appeared when Scandinavia was transitioning to agriculture over 6 kya, with J1c being the most common lineage there today. Changes in the distribution of haplogroup J mtDNAs were likely driven by the expansion of farming from West Asia into Southern Europe, followed by a later expansion into Scandinavia, with other J subhaplogroups appearing among Scandinavian groups as early as the Viking Age.
A Managed Care System with Telemedicine Support for Neurological Emergencies
Authors: Erdur Hebun , Weber Joachim E. , Angermaier Anselm , Kinze Stephan , Sotoodeh Ali , Gorski Claudia , Bollweg Kerstin , Ernst Stefanie , Kandil Farid I. , Behrens Janina , Ganeshan Ramanan , Keysers Anne , Kotlarz‐Böttcher Malgorzata , Peters Daniel , Schlemm Ludwig , Stangenberg‐Gliss Kirsten , Witt Carl , Hennig Beata , Reber Katrin C. , Schneider Udo , Franke Christiana , Schmehl Ingo , Straub Hans‐Beatus , Flöel Agnes , Theen Sarah , Endres Matthias , Kurth Tobias , Audebert Heinrich J. 
Published: November 2022

ObjectivesTelemedicine is frequently used to provide remote neurological expertise for acute stroke workup and was associated with better functional outcomes when combined with a stroke unit system‐of‐care. We investigated whether such system‐of‐care yields additional benefits when implemented on top of neurological competence already available onsite.MethodsQuality improvement measures were implemented within a “hub‐and‐spoke” teleneurology network in 11 hospitals already provided with onsite or telestroke expertise. Measures included dedicated units for neurological emergencies, standardization of procedures, multiprofessional training, and quality‐of‐care monitoring. Intervention effects were investigated in a controlled study enrolling patients insured at 3 participating statutory health insurances diagnosed with acute stroke or other neurological emergencies. Outcomes during the intervention period between November 2017 and February 2020 were compared with those pre‐intervention between October 2014 and March 2017. To control for temporal trends, we compared outcomes of patients with respective diagnoses in 11 hospitals of the same region. Primary outcome was the composite of up‐to‐90‐day death, new disability with the need of ambulatory or nursing home care, expressed by adjusted hazard ratio (aHR).ResultsWe included 1,418 patients post‐implementation (55% female, mean age 76.7 ± 12.8 year) and 2,306 patients pre‐implementation (56%, 75.8 ± 13.0 year, respectively). The primary outcome occurred in 479/1,418 (33.8%) patients post‐implementation and in 829/2,306 (35.9%) pre‐implementation. The aHR for the primary outcome was 0.89 (95% confidence interval [CI]: 0.79–0.99, p = 0.04) with no improvement seen in non‐participating hospitals between post‐ versus pre‐implementation periods (aHR 1.04; 95% CI: 0.95–1.15).InterpretationImplementation of a multicomponent system‐of‐care was associated with a lower risk of poor outcomes. ANN NEUROL 2023;93:511–521
NIR‐II Light Powered Asymmetric Hydrogel Nanomotors for Enhanced Immunochemotherapy
Authors: Wang Yingfei , Chen Wei , Wang Zhong , Zhu Yu , Zhao Hongxia , Wu Kun , Wu Jie , Zhang Weihua , Zhang Qing , Guo Hongqian , Ju Huangxian , Liu Ying 
Published: November 2022

AbstractNanomotors are appealing drug carriers, and the strength of the propelling force is important for their motion capability. Though high motion efficiency has been achieved with 808 nm light driven Janus‐structured noble metal nanomotors, the NIR‐I light penetration depth and material biocompatibility limit their broad application. Herein, we develop a 1064 nm NIR‐II light driven asymmetric hydrogel nanomotor (AHNM) with high motion capability and load it with doxorubicin for enhanced immunochemotherapy. Magnetic field assisted photopolymerization generates an asymmetric distribution of Fe3O4@Cu9S8 nanoparticles in the AHNM, producing self‐thermophoresis as driving force under NIR‐II irradiation. The AHNM is also functionalized with dopamine for the capture and retention of tumor‐associated antigens to boost immune activation. The as‐obtained NIR‐II light driven AHNM has a high tumor tissue penetration capability and enhances immunochemotherapy, providing a promising strategy for cancer therapy.
Synthesis of octavinyl polyhedral oligomeric silsesquioxane (ovi‐POSS) based organic/inorganic hybrid resin microspheres for rapid and efficient oils absorption
Authors: Liu Qingzhong , Ye Mingquan , Yu Gaoqiang , Han Aijun 
Published: November 2022

AbstractIn this work, a hybrid nanocomposite of poly(styrene‐co‐butyl acrylate‐co‐dodecyl acrylate) and octavinyl polyhedral oligomeric silsesquioxane (ovi‐POSS) was synthesized by suspension polymerization and the composite resin was characterized by Fourier transform infrared, scanning electron microscopy energy‐dispersive spectrometer and thermal gravimetric analysis. The effects of ovi‐POSS content on the oil absorbency of hybrid composite resin were investigated. The results indicated that the maximum saturated oil absorption rate of sample PSBLA/ovi‐POSS‐1 with 1 wt% ovi‐POSS content toward four oils and organic solvents (toluene, xylene, gasoline, and diesel) are, respectively, 20.51, 18.56, 12.48, and 7.03 g g−1, and the process taken just about 5 min. The absorption kinetic model fitting proved that the adsorption behavior of the four oils on PSBLA/ovi‐POSS‐1 resin microspheres was dominated by the physical adsorption. Besides, PSBLA/ovi‐POSS‐1 has good oil retention rate (stay over 95% after centrifuging at 3000 rpm for 5 min) and reusability (for 12 times). These excellent oil absorption performances are attributed to the loose network structure of the composite resin. The rapid and efficient oils absorption properties give the composite resin potential practical applications in many areas.
Do funding sources complement or substitute? Examining the impact of cancer research publications
Authors: Rotolo Daniele , Hopkins Michael , Grassano Nicola 
Published: November 2022

AbstractAcademic research often draws on multiple funding sources. This paper investigates whether complementarity or substitutability emerges when different types of funding are used. Scholars have examined this phenomenon at the university and scientist levels, but not at the publication level. This gap is significant since acknowledgement sections in scientific papers indicate publications are often supported by multiple funding sources. To address this gap, we examine the extent to which different funding types are jointly used in publications, and to what extent certain combinations of funding are associated with higher academic impact (citation count). We focus on three types of funding accessed by UK‐based researchers: national, international, and industry. The analysis builds on data extracted from all UK cancer‐related publications in 2011, thus providing a 10‐year citation window. Findings indicate that, although there is complementarity between national and international funding in terms of their co‐occurrence (where these are acknowledged in the same publication), when we evaluate funding complementarity in relation to academic impact (we employ the supermodularity framework), we found no evidence of such a relationship. Rather, our results suggest substitutability between national and international funding. We also observe substitutability between international and industry funding.
Do capital markets reward corporate climate change actions? Evidence from the cost of debt
Authors: Ali Khurshid , Nadeem Muhammad , Pandey Rakesh , Bhabra Gurmeet Singh 
Published: November 2022

AbstractAs a result of recurring natural disasters caused by climate change, firms are under enormous pressure to reconsider their environmental footprints. However, whether or not investors reward firms' climate change actions remains a topic of considerable debate. Using a sample of S&P 500 companies over the period 2005–2020, we hypothesise and find a significant negative relationship between climate change actions and the cost of debt, indicating that investors indeed reward corporate climate efforts in the form of lower cost funds. This relationship exists in both environmentally sensitive and non‐sensitive industries and remains negative and statistically significant even after controlling for the impact of the ongoing pandemic (COVID‐19). The findings are robust to the use of alternative measures for our variables, alternative estimation methods and after controlling for endogeneity issues. We interpret our findings within the decision‐usefulness and stakeholder‐agency theories that suggest that non‐financial information on firms' environmental performance is becoming increasingly important when borrowers' creditworthiness is assessed. Our study offers important regulatory and academic policy implications.
Occupational outcomes after high‐grade or low‐grade brain tumors in childhood: A Swedish, nationwide, registry‐based study
Authors: Lönnerblad Malin , Berglund Eva , Åberg Maria , Blomgren Klas 
Published: November 2022

AbstractBackgroundSurvivors of pediatric brain tumors are at high risk of late complications that may affect their daily life in both short‐ and long‐term perspectives.MethodsIn this nationwide registry‐based study we explored the occupational outcomes, including employment, sickness or activity compensation and parental leave, in 452 individuals in Sweden, born 1988–1996, and diagnosed with a brain tumor before their 15th birthday. Their results were compared with 2188 matched controls.ResultsThere were significant differences between cases and controls for all assessed variables. The cases had benefitted from sickness or activity compensation 11 times more often than controls (CI 7.90–15.83; p < 0.001) between 2005 and 2016. Controls were almost three times more likely to have an employment (OR 0.36; CI 0.28–0.47; p < 0.001) and nearly twice as likely to have been on parental leave (OR 0.56; CI 0.39–0.80; p = 0.002). Although cases treated for high‐grade tumors typically fared worse than those treated for low‐grade tumors, significant differences for all assessed variables were also observed for cases treated for a low‐grade tumor compared with controls.ConclusionsOur findings emphasize the need for follow‐up programs for all brain tumor diagnoses, not only those known to be at most risk. This is evident, for example, from the high number of cases who received sickness or activity compensation.
Scutellarin Attenuates Doxorubicin‐Induced Cardiotoxicity by Inhibiting Myocardial Fibrosis, Apoptosis and Autophagy in Rats
Authors: Sun Xipeng , Zhou Li , Han Yonglong , Yang Quanjun , Li Xingxia , Xin Bo , Chi Mengyi , Wang Yaxian , Guo Cheng 
Published: November 2022

AbstractThe anthracycline antibiotic doxorubicin (DOX) is an effective anticancer agent, but its clinical use is limited by dose‐dependent cardiotoxicity. Scutellarin (SCU), a natural polyphenolic flavonoid, is used as a cardioprotective agent for infarction and ischemia‐reperfusion injury. This study investigated the beneficial effect of SCU on DOX‐induced chronic cardiotoxicity. Rats were injected intraperitoneally (i. p.) with DOX (2.5 mg/kg) twice a week for four weeks and then allowed to rest for two weeks to establish the chronic cardiotoxicity animal model. A dose of 10 mg/kg/day SCU was injected i. p. daily for six weeks to attenuate cardiotoxicity. SCU attenuated DOX‐induced elevated oxidative stress levels and cardiac troponin T (cTnT), decreased left ventricular ejection fraction (LVEF) and fractional shortening (LVFS), elevated isovolumic relaxation time (IVRT), electrophysiology and histopathological alterations. In addition, SCU significantly attenuated DOX‐induced cardiac fibrosis and reduced extracellular matrix (ECM) accumulation by inhibiting the TGF‐β1/Smad2 signaling pathway. Furthermore, SCU also prevented against DOX‐induced apoptosis and autophagy as evidenced by upregulation of Bcl‐2, downregulation of Bax and cleaved caspase‐3, inhibited the AMPK/mTOR pathway. These results revealed that the cardioprotective effect of SCU on DOX‐induced chronic cardiotoxicity may be attributed to reducing oxidative stress, myocardial fibrosis, apoptosis and autophagy.
Caesalpinia palmeri: First Report on the Phenolic Compounds Profile, Antioxidant and Cytotoxicity Effect
Authors: López‐Romero J. C. , Torres‐Moreno H. , Vidal‐Gutiérrez M. , Cabrera‐Cabrera G. G. , Robles‐Zepeda R. E. , Rodríguez‐Martínez K. L. , Ortega‐García J. , Villegas‐Ochoa M. A. , Salazar‐López Norma J. , Domínguez‐Avila J. Abraham , González‐Aguilar G. A. 
Published: November 2022

AbstractThis study aimed to determine the phenolic compounds profile, antioxidant potential and cytotoxicity of extracts and fractions of Caesalpinia palmeri. Methanolic extracts were generated from C. palmeri berries, stems and flowers. The latter was subjected to liquid‐liquid partition, obtaining hexane, ethyl acetate and residues fractions. Results showed that the flower extract and ethyl acetate fraction had a larger concentration of phenolic compounds (148.9 and 307.9 mg GAE/g, respectively), being ellagic acid (6233.57 and 19550.08 μg/g, respectively), quercetin‐3‐β‐glycoside (3023.85 and 8952.55 μg/g, respectively) and gallic acid (2212.98 and 8422.34 μg/g, respectively) the most abundant compounds. Flower extract and ethyl acetate fraction also presented the highest antioxidant capacity on all tested methods (DPPH, ABTS, ORAC and FRAP) and low cytotoxicity against ARPE‐19 cells (IC50 >170 μg/mL). C. palmeri possessed high antioxidant potential, associated with the presence of phenolic compounds and low cytotoxicity, suggesting that they could represent an option to counter oxidative stress.
Design, Synthesis, and Fungicidal Activities of Indole‐Modified Cinnamamide Derivatives
Authors: Zhang Xinwei , Fang Jun , Li Chenjie , Zhang Jie , Yang Shuwen , Deng Bin , Tu Song 
Published: November 2022

AbstractDimethomorph is a kind of cinnamamide fungicide with high fungicidal activities for oomycete diseases. The commercially available dimethomorph is a mixture of two isomers, in which (Z)‐dimethomorph possessing higher activity and (E)‐dimethomorph possessing lower activity. Herein, we reported the design, synthesis and fungicidal activities of a series of novel indole‐modified cinnamamide derivatives, which used the indole group to ‘fix’ the cis‐styrene group in (Z)‐dimethomorph. The modification of the molecular structure of cinnamamide compounds could be beneficial to improve its practical application performance. Tested the fungicidal activities, it was found that compounds 8j, 9a, 9e, 9i and 9j showed excellent in vivo fungicidal activities (80–100 %) against Pseudoperonospora cubensis at a concentration of 100 mg L−1, while dimethomorph and flumorph were noneffective. Moreover, parts of synthesized indole‐modified cinnamamide derivatives 8 (8a, 8c, 8d and 8j) and 9 (9c and 9j) exhibited the same in vivo fungicidal activities against Phytophthora infestans with dimethomorph or flumorph at a concentration of 50 mg L−1 with 100 % inhibition. The biological assay results indicated that indole‐modified cinnamamide derivatives have promising applications in the prevention and treatment of Phytophthora infestans.
Unusual penile localization of melanoma
Authors: Kaakoua Mohamed , Azami Mohamed Amine , Karmouche Yassine , Haouane Mohamed Amine , El Fadli Mohammed , Belbaraka Rhizlane , Ghoundale Omar , Essâdi Ismail 
Published: November 2022

AbstractPenile's melanoma is a rare situation, often associated with late diagnosis and high morbidity and mortality. We report the case of a 70‐year‐old man. He represented progressive skin lesions of the penile gland. A surgical biopsy with histopathological and immunohistochemical studies established the diagnosis of malignant melanoma of the penis in the metastatic stage. This case was managed by palliative immunotherapy and is currently under treatment by Pembrolizumab. Malignant melanoma of the penis represents an exceptional situation, in which only rapid diagnosis at an early stage allows treatment with optimal therapeutic results.
Sleeve gastrectomy for multiple gastric perforations in a preterm: A case report
Authors: Poddar Elisha , Shrestha Suraj , Pathak Niharika , Khadka Durand Singh , Poudel Diptee , Khadayat Ramesh , Pandey Shailendra , Ranjan Ritika , Khanal Surendra , Koirala Dinesh Prasad 
Published: November 2022

AbstractNeonatal gastric perforation (NGP) is a rare life‐threatening condition among preterm infants. NGP can occur secondary to necrotizing enterocolitis, distal obstruction, or as a result of gastric tube insertion. Sleeve gastrectomy can be a possible therapeutic option for multiple neonatal gastric perforations.