bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID‐19 Vaccination in Autoimmune Diseases (COVAD) study: Vaccine safety in idiopathic inflammatory myopathies
Authors: Gil‐Vila Albert , Ravichandran Naveen , Selva‐O'Callaghan Albert , Sen Parikshit , Nune Arvind , Gaur Prithvi Sanjeevkumar , Gonzalez Raquel Arànega , Lilleker James B. , Joshi Mrudula , Agarwal Vishwesh , Kardes Sinan , Kim Minchul , Day Jessica , Makol Ashima , Milchert Marcin , Gheita Tamer , Salim Babur , Velikova Tsvetelina , Gracia‐Ramos Abraham Edgar , Parodis Ioannis , Nikiphorou Elena , Tan Ai Lyn , Chatterjee Tulika , Cavagna Lorenzo , Saavedra Miguel A. , Shinjo Samuel Katsuyuki , Ziade Nelly , Knitza Johannes , Kuwana Masataka , Distler Oliver , Chinoy Hector , Agarwal Vikas , Aggarwal Rohit , Gupta Latika ,   COVAD Study Group
Published: July 2022

AbstractIntroduction/AimsIn this study we investigated COVID‐19 vaccination–related adverse events (ADEs) 7 days postvaccination in patients with idiopathic inflammatory myopathies (IIMs) and other systemic autoimmune and inflammatory disorders (SAIDs).MethodsSeven‐day vaccine ADEs were collected in an international patient self‐reported e‐survey. Descriptive statistics were obtained and multivariable regression was performed.ResultsTen thousand nine hundred respondents were analyzed (1227 IIM cases, 4640 SAID cases, and 5033 healthy controls [HCs]; median age, 42 [interquartile range, 30‐455] years; 74% female; 45% Caucasian; 69% completely vaccinated). Major ADEs were reported by 76.3% of the IIM patients and 4.6% reported major ADEs. Patients with active IIMs reported more frequent major (odds ratio [OR], 2.7; interquartile range [IQR], 1.04‐7.3) and minor (OR, 1.5; IQR, 1.1‐2.2) ADEs than patients with inactive IIMs. Rashes were more frequent in IIMs (OR, 2.3; IQR, 1.2‐4.2) than HCs. ADEs were not impacted by steroid dose, although hydroxychloroquine and intravenous/subcutaneous immunoglobulins were associated with a higher risk of minor ADEs (OR, 1.9; IQR, 1.1‐3.3; and OR, 2.2; IQR, 1.1‐4.3, respectively). Overall, ADEs were less frequent in inclusion‐body myositis (IBM) and BNT162b2 (Pfizer) vaccine recipients.DiscussionSeven‐day postvaccination ADEs were comparable in patients with IIMs, SAIDs, and HCs, except for a higher risk of rash in IIMs. Patients with dermatomyositis with active disease may be at higher risk, and IBM patients may be at lower risk of specific ADEs. Overall, the benefit of preventing severe COVID‐19 through vaccination likely outweighs the risk of vaccine‐related ADEs. Our results may inform future guidelines regarding COVID‐19 vaccination in patients with SAIDs, specifically in those with IIMs. Studies to evaluate long‐term outcomes and disease flares are needed to shed more light on developing future COVID‐19 vaccination guidelines.
Measuring moral distress in nurses during a pandemic: Development and validation of the COVID‐MDS
Authors: Cramer Emily , Smith Jessica , Rogowski Jeanette , Lake Eileen 
Published: July 2022

AbstractThe COVID‐19 pandemic created novel patient care circumstances that may have increased nurses' moral distress, including COVID‐19 transmission risk and end‐of‐life care without family present. Well‐established moral distress instruments do not capture these novel aspects of pandemic nursing care. The purpose of this study was to develop and evaluate the psychometric properties of the COVID‐19 Moral Distress Scale (COVID‐MDS), which was designed to provide a short MDS that includes both general and COVID‐19‐specific content. Researcher‐developed COVID‐19 items were evaluated for content validity by six nurse ethicist experts. This study comprised a pilot phase and a validation phase. The pilot sample comprised 329 respondents from inpatient practice settings and the emergency department in two academic medical centers. Exploratory factor analysis (EFA) was conducted with the pilot data. The EFA results were tested in a confirmatory factor analysis (CFA) using the validation data. The validation sample comprised 5042 nurses in 107 hospitals throughout the United States. Construct validity was evaluated through CFA and known groups comparisons. Reliability was assessed by the omega coefficient from the CFA and Cronbach's alpha. A two‐factor CFA model had good model fit and strong loadings, providing evidence of a COVID‐19‐specific dimension of moral distress. Reliability for both the general and COVID‐19‐specific moral distress subscales was satisfactory. Known groups comparisons identified statistically significant correlations as theorized. The COVID‐MDS is a valid and reliable short tool for measuring moral distress in nurses including both broad systemic sources and COVID‐19 specific sources.
L1 finite‐time control of discrete‐time switched positive linear systems with mode‐dependent persistent dwell‐time switching
Authors: Zhang Niankun , Chen Guoyong 
Published: July 2022

AbstractThis article mainly investigates the state‐feedback finite‐time control problem for discrete‐time switched positive linear systems with mode‐dependent persistent dwell‐time (MDPDT) switching. The MDPDT switching is more general than the common dwell‐time and average dwell‐time switching because it can perfectly model a type of switched systems with hybrid slow and fast switching properties. Considering the positivity of the system, we adopt multiple linear copositive Lyapunov functions instead of traditional quadratic Lyapunov functions and derive sufficient criteria of finite‐time stability by utilizing the linear programming approach. Then the relationship between the lower bound of such switching signals and parameters of the constructed controllers is found successfully, and a sufficient condition to ensure that the closed‐loop switched system maintains positive and finite‐time bounded is proposed. Finally, the efficiency of our developed conclusions is validated by two illustrative examples.
Social, emotional, and behavioral functioning in young childhood cancer survivors with chronic health conditions
Authors: Mader Luzius , Sláma Tomáš , Schindera Christina , Rössler Jochen , von der Weid Nicolas X , Belle Fabiën N , Kuehni Claudia E 
Published: July 2022

AbstractBackgroundThe cancer diagnosis and its intensive treatment may affect the long‐term psycho‐social adjustment of childhood cancer survivors. We aimed to describe social, emotional, and behavioral functioning and their determinants in young childhood cancer survivors.ProcedureThe nationwide Swiss Childhood Cancer Survivor Study sends questionnaires to parents of survivors aged 5–15 years, who have survived at least 5 years after diagnosis. We assessed social, emotional, and behavioral functioning using the Strengths and Difficulties Questionnaire (SDQ). The SDQ includes four difficulties scales (emotional, conduct, hyperactivity, peer problems), a total difficulties indicator, and one strength scale (prosocial). We compared the proportion of survivors with borderline and abnormal scores to reference values and used multivariable logistic regression to identify determinants.ResultsOur study included 756 families (response rate of 72%). Thirteen percent of survivors had abnormal scores for the total difficulties indicator compared to 10% in the general population. The proportion of survivors with abnormal scores was highest for the emotional scale (15% vs. 8% in the general population), followed by the peer problems scale (14% vs. 7%), hyperactivity (8% vs. 10%), and conduct scale (6% vs. 7%). Few survivors (4% vs. 7%) had abnormal scores on the prosocial scale. Children with chronic health conditions had a higher risk of borderline and abnormal scores on all difficulties scales (all p < 0.05).ConclusionMost childhood cancer survivors do well in social, emotional, and behavioral life domains, but children with chronic health conditions experience difficulties. Therefore, healthcare professionals should offer specific psycho‐social support to these survivors.
Towards zero percent treatment abandonment of patients with common and curable childhood cancer types in Blantyre, Malawi
Authors: Chakumatha Eunice , Khofi Harriet , Landman Lisa , Weijers Janna , Bailey Simon , Chagaluka George , Molyneux Elizabeth , Israels Trijn 
Published: July 2022

AbstractBackgroundTreatment abandonment is a common cause of treatment failure in low‐income countries (LIC). We implemented a comprehensive package of interventions aiming to enable all families to complete the treatment of their child. The objective of this study was to evaluate the impact of those interventions.ProcedureIn this prospective and historically controlled study, we included all children younger than 16 years with a newly diagnosed common and curable cancer type (acute lymphoblastic leukaemia [ALL], Hodgkin disease, Wilms tumour, retinoblastoma and Burkitt lymphoma) admitted to the Queen Elizabeth Central Hospital in Blantyre, Malawi, between 1 June 1 2019 and 1 June 1 2020. Interventions to enable treatment completion included full funding of costs to the family (treatment, transport, accommodation and food in the hospital) and tracking of patients if they did not attend treatment appointments. The outcomes of patients were compared with those of a similar historical cohort.ResultsThe intervention cohort of 150 patients were compared to 264 historical control patients. Treatment abandonment decreased significantly from 19% (49/264) to 7% (10/150) (p < .001). The proportion of patients with Wilms tumour, retinoblastoma or ALL alive without evidence of disease at the end of treatment increased from 38% (57/149) to 53% (44/83) (p = .03).ConclusionA simple and relatively low‐cost comprehensive intervention package with no costs for families, significantly decreased treatment abandonment. This strategy may increase survival of children with common and curable cancers in LIC, especially when coupled with improvements in access to treatment and quality of treatment, including supportive care.
Strain monitoring in reduced graphene oxide‐coatedglass fiber/epoxy composite
Authors: Reghat Mojdeh , Fuss Franz Konstantin , Middendorf Peter , Bjekovic Robert , Hyde Lachlan , Hameed Nishar , Fox Bronwyn 
Published: July 2022

AbstractThis study investigates the influence of reduced graphene oxide (rGO) coated glass fabrics on the strain sensing and the mechanical characteristics of fiber‐reinforced composites. Graphene oxide was applied in two thicknesses (threefold and fivefold coatings) onto a fabric using a padder mangle machine followed by thermal reduction and infused with an epoxy to manufacture rGO‐enhanced composite. The tensile modulus and flexural strength of the rGO‐enhanced composites with threefold coating were improved by 27% and 6.2%, respectively, compared with the equivalent composite manufactured without rGO. The normalized resistance (ΔR/R0) of composites increased by 0.89% and 3.48% under a cyclic tensile force of 1000 and 4000 N. The magnitude of ΔR/R0was stable within 30 cycles suggesting a consistent strain sensing performance with a gauge factor of 15.55. The electrical response of the rGO‐enhanced composite was evaluated using a new industrial standard for sensors, by assessing calibration curves. The composite showed low hysteresis and low electrical viscosity which make these materials suitable for industrial piezoresistive strain sensors.
Improved damage sensing with random/aligned carbon nanofiber in bulk epoxy and adhesive joints
Authors: Chanda Amit , Sinha Sujeet K. , Datla Naresh V. 
Published: July 2022

AbstractIn situ health monitoring of polymeric materials and adhesive joints can be done by adding conductive carbon nanofillers that enable inherent piezoresistive sensing capability in nonconductive polymers. In this study, carbon nanofiber (CNF) was added to epoxy in bulk and adhesive form to investigate their potential applications as strain and crack detection sensors, respectively. Tensile specimens of CNF/epoxy nanocomposites with different filler concentrations were tested to study their strain sensing capability. The nanocomposites were further used as adhesive for sensing crack propagation in adhesive joints. CNFs alignment was carried out inside the adhesive by AC electric field to study the alignment effect on crack detection capability and fracture toughness of joints. Tensile specimens showed excellent strain sensing capability at CNF concentrations of 0.4, 0.8, and 1.2 wt%. However, the gauge factor was found to be highest at 0.4 wt% and decreasing further with increasing CNF content. The CNF addition was found to enhance the crack detection capability as well as the fracture toughness in adhesive joints. Further improvements in the crack detection capability and fracture toughness were observed in the case of aligned nanocomposite joints. However, the effect of alignment was observed to be more profound at lower CNF content.
Nonlinear buckling of axially compressed FG‐GRCL stiffened cylindrical panels with a piezoelectric layer by using Reddy's higher‐order shear deformation theory
Authors: Nam Vu Hoai , Dong Dang Thuy , Van Doan Cao , Phuong Nguyen Thi 
Published: July 2022

AbstractThis paper proposed a new analytical approach for the nonlinear buckling behavior of axially compressed functionally graded graphene reinforcement composite laminated (FG‐GRCL) stiffened cylindrical panels with the piezoelectric layers resting on the Pasternak's elastic foundation in the uniformly distributed temperature change. A design for the reinforcement of stiffened cylindrical panels is applied where the polymer matrixes of panels and stiffeners are reinforced by graphene sheets. The effects of FG‐GRCL stiffeners are modeled using the improved smeared stiffener technique, which is developed by applying the anisotropic higher‐order shear deformation beam theories for curved and straight stiffeners. The fundamental formulations are obtained by applying Reddy's higher‐order shear deformation theory (HSDT), and taking into account the von Kármán geometrical nonlinearities. The algebraically nonlinear equilibrium equations are achieved by employing Galerkin's procedure, and then they can be solved by using the ordinary calculation process. Some important remarks on the nonlinear buckling of stiffened FG‐GRCL cylindrical panels are archived from the numerical investigation process.
Fascinating flame resistance of polycaprolactam copolymer containing d‐glucopyranose for melt‐spun flame retardant fibers
Authors: Zhai Gongxun , Li Lili , Xiang Hengxue , Hu Zexu , Zhou Jialiang , Zhu Meifang 
Published: July 2022

AbstractImproving the flame retardant performance of polycaprolactam (PA6) will greatly expand its applications. At present, the commonly used reactive flame retardants of PA6 mainly come from the petrochemical industry. Therefore, d‐glucopyranose, a green renewable biomass, is selected and bonded to the PA6 molecular chain through in situ polymerization to obtain a series of flame retardant polyamides (PA6/Gl) and their high‐speed melt‐spun fibers. When its added amount was 2 wt%, the LOI and UL‐94 of PA6/Gl reached 29.4 Vol% and V‐0 level, and the char residue was 529.4% higher than that of neat PA6 after thermogravimetric test. d‐glucopyranose contains a polyhydroxy structure that can capture the hydrogen radicals generated by homogeneous cracking during combustion, increasing the content of CO2 and H2O and forming a smooth and dense carbon isolation layer. Thus, the synergistic flame retardant effect of green d‐glucopyranose on the gas and condensed phases of PA6 is achieved.
High prescribing of antibiotics is associated with high prescribing of opioids in medical and dental providers
Authors: Evans Charlesnika T. , Fitzpatrick Margaret A. , Poggensee Linda , Gonzalez Beverly , Gibson Gretchen , Jurasic M. Marianne , Echevarria Kelly , McGregor Jessina C. , Gellad Walid F. , Suda Katie J. 
Published: July 2022

AbstractStudy ObjectiveHigh prescribers of antibiotics and opioids are an important target for stewardship interventions. The goal of this study was to assess the association between high antibiotic and high opioid prescribing by provider type.DesignA national cross‐sectional study.Setting2015–2017 Department of Veterans Affairs (VA) electronic health record data.PopulationPrescribers were identified as dentists (2017: n = 1346) and medical providers (physicians n = 23,072; advanced practice providers [APP] n = 7705; and other providers [pharmacists/chiropractors] n = 3674) (2017: n = 34,451).MeasurementsHigh prescribing was defined as being in the top 25% of visit‐based rates of antibiotic or opioid prescribing (number of prescriptions/number of dental or medical visits). Multivariable random effects logistic regression with clustering by facility was used to assess the adjusted association between high antibiotic and opioid prescribing.ResultsMedical providers prescribed 4,348,670 antibiotic and 10,256,706 opioid prescriptions; dentists prescribed 277,170 antibiotic and 124,103 opioid prescriptions. Among all high prescribers of antibiotics, 40% were also high prescribers of opioids as compared to 18% of those who were not high antibiotic prescribers (p < 0.0001). High prescribing of antibiotics was associated with high prescribing of opioids in medical providers (adjusted odds ratio [aOR] = 2.87, 95% confidence interval [CI] = 2.72–3.04) and dentists (aOR = 8.40, 95% CI 6.00–11.76). Older provider age, specific US geographic regions, and lower VA facility complexity and rurality were also associated with high opioid prescribing by medical providers. In dentists, younger provider age, male gender, specific regions of the United States, and lower number of dentists in a facility were associated with high opioid prescribing. At the facility level, high dental prescribers of antibiotics or opioids were not at the same facilities as high medical prescribers, respectively (p < 0.0001).ConclusionsHigh antibiotic prescribing was associated with high opioid prescribing. Thus, stewardship interventions targeting both medication classes may have higher impact to efficiently reduce prescribing of medications with high public health impact. Provider‐targeted interventions are needed to improve antibiotic and opioid prescribing in both dentists and medical providers.
Randomized controlled trial to compare safety and efficacy of mycophenolate vs. cyclosporine after rituximab in children with steroid‐resistant nephrotic syndrome
Authors: Assadi Farahnak , Mazaheri Mojgan , Sadeghi‐Bodj Simin 
Published: July 2022

AbstractObjectiveThe comparative safety and efficacy of maintenance mycophenolate mofetil (MMF) and cyclosporine (CYC) following rituximab (RTX) in children with steroid‐resistance nephrotic syndrome are uncertain.Study Design and settingMulticenter randomized controlled trial.PatientsSixty‐six children between 2 and 6 years of age with SRNS.InterventionsPatients were randomized to receive either MMF 1000 mg/m2/day (n = 32) or CYC 5 mg/kg/day (n = 34) for 12 months following RTX induction therapy (375 mg/m2) given as needed for B‐cell count.Main outcomesComplete remission and adverse events (AEs).ResultsComplete remission was observed in 26 patients (83.1%) in the MMF group compared with 21 patients (61.7%) in the CYC group (p = 0.02). The median time to remission was shorter in the MMF group than in the CYC group (2.64 vs. 3.4 months; hazard ratio [HR], 0.61; 95% CI, 0.74–0.90, p = 0.03). The median time to first relapse was longer in the MMF group compared with the CYC group (10.8 vs. 8.0 months; HR, 1.12; 95% CI, 1.31–1.54, p = 0.01), and this was significantly correlated with the median time to B‐cell recovery in the two groups (8.6 vs. 5.2 months in MMF and CYC, respectively, p = 0.02). The overall incidence of adverse drug events was lower in the MMF group compared with the CYC group (59.3% vs. 76.4%, p = 0.03).ConclusionsMMF‐RTX is superior to CYC‐RTX in maintaining remission with fewer AEs in children with initial SRNS. Additional high‐quality randomized control trials with long‐term follow‐up are needed to identify the long‐term potential complications.
Vancomycin area under the curve versus trough only guided dosing and the risk of acute kidney injury: Systematic review and meta‐analysis
Authors: Abdelmessih Emily , Patel Nandini , Vekaria Janaki , Crovetto Brynna , SanFilippo Savanna , Adams Christopher , Brunetti Luigi 
Published: July 2022

AbstractVancomycin is commonly used to treat methicillin‐resistant Staphylococcus aureus infections and is known to cause nephrotoxicity. Previous Vancomycin Consensus Guidelines recommended targeting trough concentrations but the 2020 Guidelines suggest monitoring vancomycin area under the curve (AUC) given the reduced risk of acute kidney injury (AKI) at similar levels of efficacy. This meta‐analysis compares vancomycin‐induced AKI incidence using AUC‐guided dosing strategies versus trough‐based monitoring. Literature was queried from Medline (Ovid), Web of Science, and Google Scholar from database inception through November 5, 2021. Interventional or observational studies reporting the incidence of vancomycin‐induced AKI between AUC‐ and trough‐guided dosing strategies were included. In the primary analysis, the Vancomycin Consensus Guidelines definition for AKI was used if reported; otherwise, the Risk, Injury, and Failure; and Loss, and End‐stage kidney disease (RIFLE) or Kidney Disease Improving Global Outcomes (KDIGO) definitions were used. The incidence of nephrotoxicity was evaluated between the two strategies using a Mantel–Haenszel random‐effects model, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Subgroup analyses for adjusted ORs and AKI definitions were performed. Heterogeneity was identified using Cochrane's Q test and I2 statistics. A total of 10 studies with 4231 patients were included. AUC‐guided dosing strategies were associated with significantly less vancomycin‐induced AKI than trough‐guided strategies [OR 0.625, 95% CI (0.469–0.834), p = 0.001; I2 = 25.476]. A subgroup analysis of three studies reporting adjusted ORs yielded similar results [OR 0.475, 95% CI (0.261–0.863), p = 0.015]. Stratification by AKI definition showed a significant reduction in AKI with the Vancomycin Consensus Guidelines definition [OR 0.552, 95% CI (0.341–0.894), p = 0.016] but failed to find significance in the alternative definitions. Area under the curve‐guided dosing strategies are associated with a lower incidence of vancomycin‐induced AKI versus trough‐guided dosing strategies (GRADE, low). Limitations included the variety of AKI definitions and the potential for confounding bias.
Transfer of PREPaRE school crisis training: Moderating effects of trainee characteristics
Authors: Parks Timothy W. , Nickerson Amanda B. , Fredrick Stephanie S. , Sodano Sandro M. 
Published: July 2022

AbstractThe National Association of School Psychologists developed the PREPaRE School Crisis Prevention and Intervention Training Curriculum to help schools plan for and prevent school crises and to help mitigate the effects after a crisis occurs. In this study, 279 participants who attended the PREP
aRE training between 1 and 24 months before the survey date completed measures assessing work environment, trainee characteristic, and training design variables as well as the transfer of PREP
aRE‐specific knowledge and skills. Utilizing structural equation modeling, unique effects of Work Environment and Trainee Characteristic variables on knowledge and skill transfer and the extent to which Trainee Characteristics moderate effects of the Work Environment were assessed. Results indicated a significant moderating effect such that trainees who were less motivated compared to those who were more motivated demonstrated greater transfer when they worked in more supportive, open, and rewarding environments. Overall, results from this study provide evidence to support addressing many individual and contextual variables to improve the transfer of PREP
aRE‐specific knowledge and skills. Implications for practice are discussed.