bluuebunny/crossref_metadata_2025_split huggingface dataset:
The modified Latarjet procedure in the treatment of anterior shoulder instability with significant bone loss: a case series
Authors: Mekky Ahmed Farid , Fossati Chiara , Menon Alessandra , Randelli Pietro Simone , Aly Tarek 
Published: August 2022

Abstract
Background
Recurrent anterior shoulder instability is a common problem and may be associated with glenoid bone defects. It is important to treat these bone defects appropriately because they are a cause of failed instability repair. Surgical procedures including Latarjet are the usual treatment for anterior shoulder instability associated with significant glenoid bone defects. The aim of this study was to evaluate the clinical outcome and gleno-humeral arthritis progression in patients with recurrent anterior shoulder instability and significant bone loss treated by a modified Latarjet procedure.
Methods
From July 2018 to November 2021, 21 patients with recurrent anterior shoulder instability associated with significant bone defects were treated by a modified Latarjet procedure. The patients were post-operatively assessed using modified Rowe scoring.
Results
The mean age at time of surgery was 28.52 ± 8.0 (range: 19–45) years. The mean number of dislocations was 18.33 ± 8.67 (range: 6–35) times. The mean glenoid defect size was 26.19 ± 4.85 (range: 21–37) % and Hill-Sachs lesions were off track in 19 cases. The mean follow-up period was 30.67 ± 7.53 (range: 16–40) months. Eighteen patients (85.7%) showed good to excellent results. The mean modified Rowe score was 85.00 ± 18.77 (range: 30–100) points. The mean external rotation loss was 8.09 ± 5.11° (range: 0–20°). None of the patients showed recurrence of instability and arthritis progression.
Conclusion
The modified Latarjet is an effective and reliable surgical option to treat traumatic anterior shoulder instability with significant bone loss. Most of the reported complications associated with this procedure didn’t affect the functional outcome.
Physico-Mechanical Properties of Biodegradable Composite making with Polylactic acid (PLA) and Spinning Mill Wastage Reinforcement
Authors: -E-Karim Fahmida , Begum Hosne Ara , Islam Md. Redwanul , Siddique Abu Bakr 
Published: August 2022

Abstract
Biodegradable composite materials are getting popular day by day for creating a sustainable environment. The focus of this article is to introduce spinning mill wastage (seeds, short fibers, foreign materials etc.) as reinforced material with biodegradable matrix that is polylactic acid for comparing its property as a replacement of expended polystyrene (EPS) foam packing material. Hand lay-up process is used for making the composite. The mechanical characterization of the composite is done by doing tensile, bending and compression strength test. Surface topography of the composite is analyzed by testing the sample with SEM. This study shows that the mechanical property of this composite is quite similar to EPS but the porosity of the sample needs to be developed for ensuring better property of the composite.
Photoredox C-H Functionalization Leads the Site-selective Phenylalanine Bioconjugation
Authors: Weng Yue , Su Chun-Jen , Jiang Haoyang , Chiang Chien-Wei 
Published: August 2022

Abstract
Site-selectively chemical bioconjugation of peptides and proteins can improve the therapeutic exploration of modified protein drugs. Only 3.8% natural abundance of phenylalanine in protein and nearly 90% of proteins contain at least one phenylalanine residue in their sequenced, showing the potential in biopharmaceutical utility of the phenylalanine bioconjugation. However, the covalent bioconjugation of native phenylalanine is one of the most challenging problems in protein modification. Herein, an approach to protein modification is described that relies on a photoredox method for the site-selective bioconjugation of phenylalanine. This methodology has been validated on peptides as well as protein insulin using a straightforward and mild condition. In addition, based on characterization by near-UV CD spectroscopy and small angle X-ray scattering (SAXS), this pyrazole labeling approach permitted the insulin hexamer to completely dissociate into the monomeric form, thus making it a potential candidate for use as rapid-acting insulin for the treatment of diabetes.
Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector
Authors: Morizako Nanami , Butlertanaka Erika P , Tanaka Yuri L , Shibata Honoka , Okabayashi Tamaki , Mekata Hirohisa , Saito Akatsuki 
Published: August 2022

Abstract
Human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors are indispensable tools for gene engineering in mammalian cells. Conversely, lentiviral vector transduction is severely inhibited in bovine cells. Previous studies demonstrated that this inhibition is caused by the anti-lentiviral host factor tripartite motif containing 5 (TRIM5), which targets incoming HIV-1 virions by interacting with the viral capsid. In this study, we investigated several methods for overcoming the limited applicability of lentiviral vectors in bovine cells. First, we demonstrated that the SPRY domain of bovine TRIM5 is the major determinant of anti-viral activity. Second, we found that mutations that allow the capsid to evade rhesus macaque TRIM5α minimally rescued HIV-1 infectivity in bovine-derived MDBK cells. Third, we found that cyclosporine A, which relieves the inhibition of HIV-1 infection in monkey cells, significantly rescued the impaired HIV-1 infectivity in MDBK cells. Lastly, we successfully generated a bovine cell line lacking intact TRIM5 using the CRISPR/Cas9 technique. This TRIM5 knockout cell line displayed significantly higher susceptibility to an HIV-1-based lentiviral vector. In conclusion, our findings provide a promising gene engineering strategy for bovine cells, thereby contributing to innovations in agriculture and improvements in animal health.
Designing, Developing, pilot implementation and evaluation of a mobile android based tool to improve health outcomes in adolescents and young adults living with HIV: An Agile model Human-Centered Design Science three-phase Methodology.
Authors: Rufu Annah , Chitindingu Kudakwashe , Chinofunga Shakemore , Dupwa Beatrice , Mugurungi Owen 
Published: August 2022

Abstract
Purpose: The objective of this study was to close the gap in healthcare providers’ skills, training and information sharing in HIV management by developing a mHealth artifact, with the aim of improving health management outcomes. Methods: This study used a three-phase Design Science human-centred methodology to develop the AnnMac android based communication application artifact. The design science methodology used consisted of problem identification, solution design and evaluation of the AnnMac application user experiences and impact. A descriptive cross-sectional case study used data collected from the literature review, and primary data from the participatory research approach. Secondly we used data collected from the AnnMac application user experiences and impact evaluation. Results: The AnnMac application was designed, developed, pilot implemented and registered on Google store and was ready for download by January 2020. Conclusions The evaluation of the AnnMac android mobile application showed a high rate (<85%) of adoption due to its simple-to-use features resulted in improved adherence to antiretroviral therapy and viral load suppression among patients and improved health care worker satisfaction and engagement in HIV care. Furthermore, the AnnMac m-health android based communication application helped health care providers communicate and engage with adolescents and young adults living with HIV using relevant guidelines and tailor made messages or information. In addition the AnnMac m-health android based communication application enabled health care providers manage adolescents and young adults living with HIV healthcare progress in improving their HIV management resulting in improved adherence to antiretroviral therapy and viral load suppression among patients.
Egyptian perception, awareness, and knowledge of nanotechnology: A study based on an Egyptian University approach
Authors: Ead Hamed , Elsherif Rabab , Hassan Hosam , salah ayatallah 
Published: August 2022

Abstract
Scientific literacy as a goal of a science education reform remains a critical discourse in the research literature. It is crucial to students’ understanding and acceptance of emergent technologies like nanotechnology (NT). Due to informational input from physicists, chemists, engineers, geologists, and biologists, NT is a vibrant field of science today. Despite the extensive use of nanomaterials (NMs) in daily life, little is known by the general public regarding the capabilities, advantages, and potential risks of NT. Like with any emerging technology, its public perception has direct implications on future policies and has to be taken into considerations by both academia and industry. An online survey of sociodemographic graduates was conducted as part of the interdisciplinary awareness initiative at Cairo University. The survey was prepared based on previous studies and introduced to the staff, graduates, and students sample of Cairo University (343 votes), selected from different faculties in different stages, were considered. The resulting data were analyzed using SPSS technical analysis method. The main goal was to evaluate the current levels of knowledge and the attitude toward NT among the general Egyptian public and to determine how the differing sociodemographic factors (e.g., in terms of age, sex, and educational background) may affect it. This paper summarizes the findings of a study of public attitudes toward NT, highlighting both concerns and aspirations for NT, and discusses the impacts of that data on public engagement programs. We found that while Egyptians display a generally optimistic view and a positive attitude toward NT, there are concerns about its safety and possible risks. Participants expressed a great desire for more information about its applications and clear labeling and transparency of products containing NMs. Notably, we found that participants with a university degree were generally more knowledgeable on this topic; surprisingly, there were no significant differences in the attitude toward NT among people from different educational backgrounds. This shows the difficulty in mitigating public aversion solely by providing more information on the subject; depending on who you talk to, the perception of what the public thinks about NT can vary.
Numerical investigations on the surface integrity of a mechanical part machined by the end milling process using different teeth of the milling cutter
Authors: Benattia Bloul , Benaoumeur Aour , Hélène Chanal , Nargess Chtioui , Riad Harhout 
Published: August 2022

Abstract
This study allows to analyze the influence of the teeth number of the milling cutter during end milling machining on the surface quality, mechanical characteristics, cutting forces, are valuable in terms of providing high precision and efficient machining in order to give a new approach to improve the surface quality of a mechanical part, reducing residual stresses, cutting forces by the material removal process. The Surface roughness is particularly sensitive to the runout errors of the insert, number of cutter teeth and the nose radius during this type of machining. This paper is a comparative study of the surface finish, stresses, and cutting forces when machining with a 2, 6 and 8 tooth cutter under the same cutting conditions. In addition to the investigations on the surface integrity and the comparative geometrical study, we have provided a calculation tool to simulate the influence of the residual stresses and the loads applied on the mechanical part. This approach examines the characteristics of the surface topography of aluminum parts, a stainless steel tool and the material strength of this part in general. The investigation is carried out by several simulated and realizable tests and performed on the HPC unit and the machine tool by exploiting the finite element method in the case of stable machining. The exploitation of the finite element method has led to promising results in terms of propagation of the machined surface state, residual stresses and cutting forces which have a considerable effect on the wear on the main edge of the cutter. The simulation shows that the roughness of the surface condition is inversely influenced by the teeth number of the end mill, the cutting forces as well as the residual stresses.
Bisimidazole ionic liquid functionalized ZIF-8 solid-phase extraction coupled with high performance liquid chromatography for analysis Rhodamine B in food samples
Authors: Zhu Xiashi , Wan Shuyu , Xu Ouwen , Song Hanyang , Yang Jing 
Published: August 2022

Abstract
An effective method based on the bisimidazole ionic liquid functionalized ZIF-8 solid-phase extractant (ZIF-8@MIM-MIM) coupled with high performance liquid chromatography (HPLC) for the separation/analysis of Rhodamine B was established. ZIF-8@MIM-MIM was characterized by FTIR, XRD, SEM and TEM. Several important factors, such as pH, amount of extractant, extract time and types of eluents were investigated in detail. Under the optimal conditions, linear range of the method was 0.02-40.00 µg mL− 1, the detection limit was 7.0 ng mL− 1, and the linear correlation was good (R2 = 0.9986). The detection of Rhodamine B in chili powder, red wine, plum juice and strawberry jam proved that the method was simple and effective, and could be used to separate and analyze Rhodamine B in real samples.
Highly selective epoxidation of styrene at ambient temperature under photo-assisted condition over bimetallic Eu and Ti-doped amino-functionalized mesoporous molecular sieve
Authors: wang guangjian , gao hongyu , cao qingxi 
Published: August 2022

Abstract
Mesoporous molecular sieves silica materials had been functionalized employing 3-aminopropyltriethoxysilane as the surface decoration agent by a post-synthesis method and Eu and Ti with different loading ratio were synchronously anchored on amino-functionalized silica framework by incipient wetness impregnation method, respectively. The structures of the synthesized samples were evaluated by means of X-ray diffraction, Fourier transform infrared spectroscopy, ultraviolet-visible spectra, scanning electron microscope, transmission electron microscope, X-ray photoelectron spectroscopy and solid-state 29Si magic angle spinning nuclear magnetic resonance spectra. The results revealed that the highly ordered mesoporous two dimensional hexagonal structure and the mesoporous channel structure were well preserved and isolated tetrahedral surface Eu3+ and isolated [TiO4] or [HOTiO3] species were found to be grafted and highly dispersed in the amino-functionalized mesoporous framework. A significant enhancement in selectivity and conversion for the photocatalytic epoxidation of styrene has been achieved by synergistic effect based on surface ligand effect and electron density effect between Eu3+ and Ti4+ species on amino-functionalized mesoporous silica framework. The factors associated with the conversion of styrene and selectivity to styrene oxide such as the solvent, metal loading, the amount of NaOH, H2O2/Styrene, the amount of catalyst and reaction time were also investigated in details. The desired selectivity (84%) to styrene oxide and excellent conversion (32%) of styrene for the photocatalytic epoxidation of styrene with turnover frequency of 3.1×10-4s-1 were obtained using aqueous H2O2 as an oxidant in the presence of acetonitrile solvent under ambient temperature.
Clinical outcomes and treatment patterns of older adults with dementia-related psychosis by dementia type in the United States
Authors: Forns Joan , Danysh Heather E. , McQuay MBioinf Lisa J. , Turner Mary Ellen , Dempsey RN Colleen , Anthony Mary S. , Demos George , Layton J. Bradley 
Published: August 2022

Abstract
Background
Little is known about the incidence of clinical events and treatment patterns among older adults with dementia-related psychosis (DRP). Given that DRP is composed of various dementia types, this current study describes the similarities and differences across the dementia types in the incidence of clinical events and treatment patterns after patients with dementia are diagnosed with psychosis.
Methods
Adults aged ≥ 65 years and newly diagnosed with DRP were identified in US Medicare claims during 2013–2018. Baseline characteristics were evaluated at the time of the initial DRP diagnosis. After DRP diagnosis, for each dementia type (Alzheimer’s disease [AD], Parkinson’s disease dementia [PDD], dementia with Lewy bodies [DLB], frontotemporal dementia [FTD], vascular dementia [VD], and dementia, unspecified), incidence rates (IRs) of clinical events (e.g., falls/fractures, infections, healthcare utilization), mortality, and patterns of antipsychotic treatment were described. Daily mean cumulative counts were estimated to describe the potentially varying incidence of recurrent events over time. Mortality by time since DRP diagnosis was described using Kaplan-Meier survival curves.
Results
We identified 484,520 patients with DRP: mean age, 84 years; female, 66%. The most prevalent type of dementia at the index date was unspecified dementia (56%), followed by AD (31%), VD (12%), PDD (10%), DLB (3%), and FTD (< 1%). At the time of DRP diagnosis, most patients had scores on the Charlson Comorbidity Index (71%) and frailty index (62%) indicating severe illness. After DRP diagnosis, IRs (per 100 person-years) were high for emergency department visits, oral anti-infective use, and urinary tract infections for all dementia types. Overall, DLB was the dementia type with the highest incidence of clinical outcomes. After 1 year of follow-up, the cumulative probability of death was about 30% for all types of dementia. After 5 years of follow-up, the cumulative probability of death was about 80% among DRP patients with DLB, VD, AD, or PDD and about 60%-65% among patients with FTD or unspecified dementia
Conclusions
Patients with DRP had a high burden of comorbidities, frailty, emergency department visits, infections, and death. Specifically, after DRP diagnosis, patients with DLB and VD had the highest burden of clinical events of interest.
Carbon fiber reinforced epoxy composite properties improvement by incorporation of polydopamine sizing at fiber-matrix interface
Authors: Qin Wenzhen , Lei Kaixuan , Yan Meiling , Li Zhongkai , Yan Yi , Hu Yongwei , Wu Zhijun , He Jianwei , Chen Liang 
Published: August 2022

Abstract
To gain better interfacial and mechanical performances of carbon fiber reinforced epoxy resin (CF/EP) composites, the surface modification of CF was carried out via a simple mild method. The polydopamine (PDA) was applied to size the CF, as well as the influence of PDA sizing time on CF were elucidated. As the PDA deposited time increases, a growing number of PDA nanoparticles were adhered on CF surface, associating with appearance of PDA agglomerates. Through analyzing the results, the optimum PDA sized time was 24 h. The introduction of PDA increase the chemical reaction and mechanical interlocking between fiber and matrix. Compared with unsized CF, the tensile strength of PDA 24 h sized CF was improved by 27.0%, the interlaminar shear strength, flexural and impact strength of PDA 24 h sized CF/EP composites increased by 103.7%, 65.6% and 163.6%, respectively. Furthermore, the fracture topographies of CF/EP composite strikingly implied that the PDA has a positive impact on the mechanical performances of CF/EP composites.
In-situ Synthesis of Bos taurus indicus Urine Assisted Ag/rGO Nanocomposite for Nitroarenes Reduction and Biological Activity
Authors: Karvekar Omkar S. , Jadhav Sarita M. , Sarvalkar Prashant D. , Vadanagekar Apurva S. , Patil Sharadchandra S. , Rane Manali R. , Sharma Kiran Kumar K , Kurhe Deepti N. , Prasad Neeraj 
Published: August 2022

Abstract
In order to effectively purify drinking water or wastewater, harmful organic contaminants like nitroarenes must be removed from water systems. In this context, the present study developed a unique bio-mimetic, in-situ synthesis of Ag/rGO nanocomposite. We employed Bos taurus indicus urine to make Ag/rGO nanocomposite in an environmentally friendly, economical, and sustainable manner. Through the use of DLS, FE-SEM, FT-IR, Raman, TGA-DSC, XRD, and Zeta Potential analysis, the morphological, elemental, and structural characterization were completed. Investigations were conducted into the catalytic effectiveness of prepared nanomaterials for diverse nitroarenes reduction. Then, using NaBH4 at 25oC, the catalytic roles of Ag and Ag/rGO nanocatalyst were assessed towards the catalytic reduction of several environmental pollutants such as 2,3 & 4-nitroaniline and 4-nitrophenol. For their catalytic performance, bio-mimetically synthesized Ag NPs were thermally treated at 200°C and compared to Ag/rGO nanocomposite. The antibacterial and antioxidant properties of as-prepared nanomaterials were investigated in this study. The finding signifies the importance of such nanocomposites in medicinal chemistry and antibacterial creams for external use.
Hospital pharmacists’, doctors’ and nurses’ perceptions of intra- and inter- professional communication in the context of electronic prescribing and medication administration systems: a qualitative study
Authors: Mohsin-Shaikh Soomal , Blandford Ann , Franklin Bryony Dean 
Published: August 2022

Abstract
Background Effective, integrated and coordinated communication is essential in providing high quality patient care. There has been limited research detailing the impact of electronic prescribing and medication administration (ePMA) systems on healthcare professionals’ (HCPs’) communication. We aimed to explore hospital pharmacists’, doctors’ and nurses’ perceptions of how ePMA systems have affected, or are expected to affect, the way they communicate with each other in an inpatient setting.MethodsThis was a qualitative study in three English NHS hospitals: two used different inpatient ePMA systems, and one used paper-based prescribing. We conducted focus groups with pharmacists, and semi-structured individual interviews with doctors and nurses. Transcribed data were analysed inductively using thematic analysis. ResultsNine focus groups, three at each hospital, were conducted with pharmacists with different levels of seniority (58 pharmacists in total). Fourteen doctors and twelve nurses took part in individual interviews. Four themes were identified: modes of communication, reduced pharmacist visibility, system limitations, and future aspirations for ePMA. Whether working with ePMA or paper-based systems, all participants preferred to communicate face-to-face to facilitate collaborative discussions regarding patient care. Participants perceived that ePMA reduced contact time with patients. Pharmacists perceived that both their physical ward presence and their written communication on medication charts had reduced since introduction of ePMA. Doctors felt they were now less likely to ask pharmacists questions due to pharmacists’ reduced physical presence on the ward. Hardware and software limitations were identified by all HCPs, with suggestions made for future developments to better support communication.Conclusion ePMA does not necessarily support communication among HCPs. Pharmacists and doctors were also concerned that ePMA reduces communication between themselves and their patients. Hospital managers should ensure sufficient hardware for HCPs, including pharmacists, to conduct their work in clinical areas, and work with ePMA system suppliers to develop ways of enhancing, rather than inhibiting, communication.