bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pilot Study Using Two Novel fMRI Tasks: Understanding Theory of Mind and Emotion Recognition Among Children With ASD
Authors: Han Yu , Prelock Patricia , Coderre Emily , Orr Joseph 
Published: March 2022

Abstract
Children with autism spectrum disorder (ASD) struggle with social interactions due to deficits in theory of mind (ToM). In this study, we collected behavioral and neuroimaging data from 9 children with ASD and 19 neurotypical children between the age of 7 and 14 years old, particularly in the area of emotion recognition to better understand those skills needed for meaningful social interaction. The results suggest impaired abilities in multiple ToM metrics and brain deficits associated with ToM-related emotion recognition and processing among children with ASD. Findings from this study are expected to establish connections between behavior and brain activities surrounding ToM in ASD, which may assist the development of neuroanatomical diagnostic criteria and provide a way to measure intervention outcomes.
Tactile Social Recognition in Octopuses
Authors: Morse Peter , Huffard Christine 
Published: March 2022

Abstract
Social recognition is the ability of individuals in a species to differentiate among conspecifics based on their identity or biologically meaningful demographic. Despite evidence that they have sophisticated brains, complex behavioural repertoires, and acute sensory processing, surprisingly little is known about mechanisms aiding social recognition in cephalopods. This class’s unique chemotactile sense by the ventral arm surfaces gathers considerable information used in predator-prey interactions. Does it also help mediate social interactions? This study utilised 366 hours of focal animal observations to assess the likelihood of Hapalochlaena maculosa, a nocturnal species, to retreat after physically contacting conspecifics based on their sex, familiarity and mating history. Females retreated from both sexes equally, while males were more likely to retreat after contacting female conspecifics. Most conspicuously, males were significantly more likely to retreat after contacting females with which they had already mated. These findings provide the first evidence for chemotactile sex discrimination and mate recognition within cephalopods, and supplement previous observations that male H. maculosa do not appear to detect the sex of conspecifics from a distance. The decision to retreat from or stay with an individual based on their sex or mating history, only after physical contact, emphasises the importance of chemotactile behaviour in octopus sensory ecology and behaviour. Furthermore, male octopuses have limited spermatophore production, and the use of chemotactile social recognition observed here may highlight the importance of reproduction, specifically sperm allocation and avoidance of sexual cannibalism, on the evolution of sensory ecology and cognition within this lineage.
A novel inflammatory response-related signature predicts the prognosis of skin cutaneous melanoma and the effect of anti-tumor drugs
Authors: Xing Jiahua , Li Yan , Chen Youbai , Han Yan 
Published: March 2022

Abstract
Skin cutaneous melanoma (SKCM) is a skin cancer that is highly metastatic and aggressive, with a dismal prognosis. This is the first study to use inflammatory response-related genes to build a model and evaluate their predictive significance in SKCM. This study used public databases to download SKCM patients’ mRNA expression profiles and clinical data to create multigene prognostic markers in the UCSC cohort. We compared overall survival (OS) between high- and low-risk groups using the Kaplan-Meier curve and determined independent predictors using Cox analysis. We also used enrichment analysis to assess immune cell infiltration fraction and immune pathway-related activity using KEGG enrichment analysis. Finally, we detected prognostic genes’ mRNA and protein expression in SKCM and normal skin tissues using qRT-PCR and IHC (data from Human Protein Atlas). Finally, we developed a 5-gene predictive model that showed that patients in the high-risk group had a considerably shorter OS than those in the low-risk group. The analysis of the receiver operating characteristic (ROC) curve proved the model’s predictive ability. Furthermore, we conducted a drug sensitivity analysis and discovered that the expression levels of prognostic genes were substantially linked with cancer cell sensitivity to antitumor medicines. The findings show that the model we developed, which consists of five inflammatory response-related genes, can be used to forecast the prognosis and immunological state of cutaneous melanoma, giving personalized medicine and precision medicine a new goal and direction.
Numerical Simulation of Microstamping Process to Fabricate Multi-channel of SUS304 Thin Sheets with Consideration of Grain Structures
Authors: Si Shangyu , Wu Qiong , Mei Deqing , Mao Wenze , Song Shufan , Xu Liming , Zuo Tao , Wang Yancheng 
Published: March 2022

Abstract
The springback behavior of thin metal sheets will significantly affect the forming accuracy of microchannels during microstamping process, especially as the forming scale reduced to micro/meso levels due to the size effects and grain structures. This paper aims to study the size effects on springback behavior and microchannel’s formability in microstamping process. The thin sheet of SUS304 specimens with different grain sizes were prepared and employed in uniaxial tensile tests to examine the stress-strain relationship and used to study the effects of grain sizes on the material’s plastic deformation behavior. A constitutive model incorporate surface layer and grain structures is developed to characterize the deformation behavior of thin-metal sheet with different grain sizes. Then, the constitutive model is utilized in finite element simulation of microstamping process to fabricate microchannel structures, and the results are verified by experimental testing. Both numerical simulation and experimental results showed that the size effect is critical in microstamping process, the developed constitutive model is able to accurately characterize the global springback behavior of thin metal sheets during microstamping process.
A rare case of cervical squamous cell carcinoma combined with sinonasal inverted Papilloma: A case report
Authors: Hou Xiaoyu , Peng Chunrong , Zhang Guonan , Wang Dengfeng 
Published: March 2022

Abstract
Background: Cervical cancer is the fourth most common malignancy in women worldwide, and sinonasal inverted papilloma (SIP) is a rare benign sinus tumor and has the characteristics of destructive growth pattern, high recurrence rate and easy canceration. Cervical squamous cell carcinoma (SCC) combined with SIP has not been reported so far. Case Presentation: A 55-year-old woman was diagnosed with cervical SCC in our center and treated with concurrent radiochemotherapy. During the follow-up period, SIP was found twice and both underwent endoscopic left nasal tumor resection. The clues that the diseases were found were the abnormal rise of squamous cell carcinoma antigen (SCCA). SCCA level decreased to normal after operations.Discussion and Conclusion: (1) when the cervical lesions have resolved satisfactorily but the SCCA is still high, other sites should be promptly investigated for the cause, which may lead to earlier detection and earlier treatment of SIP. (2) Combined with the literature, we recommend that SCCA can be used as a routine monitoring index for SIP. If available, a combination of SCCA1 and SCCA2 can be tried for further judgement. (3) For SIP with a high recurrence rate, can anti-HPV treatment be taken after operation to reduce the risk of recurrence?
The Relationship Between Glycated Hemoglobin Level and The Stage of Periodontitis in Individuals Without Diabetes
Authors: Banjar Arwa , Alyafi Rusha , Alghamdi Ali , Assaggaf Mohammed , AlMarghalani Ammar , Hassan Shaymaa , Mealey Brian 
Published: March 2022

Abstract
Background: Glycemic control appeared to have a significant impact on the relationship between periodontitis and diabetes. Since the classification of periodontitis was updated, the current study aims to investigate the association between the stage of periodontitis and HbA1c level in patients considered to be normoglycemic Methods:135 patients with no history of diabetes were included in the study. All patients received full mouth periodontal exam. Periodontal diagnosis was determined according to the 2017 World Workshop on the classification of periodontal disease. The glycemic state of patients was assessed using a chair-side HbA1c analyzer. Results:90 patients in the study were diagnosed with periodontitis. Higher average HbA1c were associated with the different stages of periodontitis (p <0.01). Most of the non-periodontitis patients were in the non-diabetes group (67%), while most of the periodontitis patients were in the undiagnosed pre-diabetes group (47% of the stages I and II group, and 44% of the stages III and IV group (p <0.001). Conclusion: Periodontitis patients are more likely to have undiagnosed dysglycemia. The elevation in HbA1c level was more evident in patients with stage III and Iv periodontitis. The result of this study suggests that patients with advanced periodontitis might be targeted for diabetes screening.
Pituitary Stalk Interruption Syndrome: Phenotype, Predictors, and Pathophysiology of Perinatal events.
Authors: Diwaker Chakra , Thadani Puja , Memon Saba Samad , Sarathi Vijaya , Lila Anurag Ranjan , Arya Sneha , Krishnappa Brijesh , Karlekar Manjiri , Patil Virendra , Shah Nalini , Bandgar Tushar 
Published: March 2022

Abstract
Purpose: There is limited data regarding Pituitary Stalk Interruption Syndrome (PSIS) from India. Moreover, the pathophysiological link between perinatal events and PSIS is unclear. We aim to elucidate the predictors of PSIS among patients with growth hormone deficiency (GHD) and perinatal events in PSIS by comparing cohorts of PSIS and genetically proven GHD without PSIS. Methods: Among 179 GHD patients, 56 PSIS and 70 genetically positive GHD (52-GHRHR, 15-POU1F1, and 3-PROP1) patients were included. Perinatal events, clinical anomalies, pituitary hormone deficiency, and imaging findings were recorded. We compared subgroup of PSIS-isolated GHD (PSIS-IGHD) with GHRHR-IGHD and subgroup of PSIS-combined pituitary hormone deficiency (PSIS-CPHD) with POU1F1/PROP1-CPHD. Results: PSIS patients (45 males, median age: 12.5 years) most commonly presented with short stature. At last follow up (median age: 17.35 years), gonadal (during pubertal-age), thyroid and cortisol axes were affected in 81.6%, 62.5%, and 62.5%. 10/13 (77%) of PSIS children with initial IGHD diagnosis manifested hypogonadism during pubertal age. Male predominance, sporadic presentation, clinical anomalies were significantly higher in both PSIS subgroups than the respective genetic subgroups. Breech presentation was higher in PSIS-CPHD than POU1F1/PROP1-CPHD (44.4% vs 5.5%, p=0.004). Neonatal hypoglycemia (22% vs. 0%, p=0.05) and jaundice (42 vs. 5%, p=0.004) were higher in PSIS-CPHD than PSIS-IGHD. Conclusion: Later age at presentation and frequent hypogonadism were observed in our PSIS cohort. Male sex, sporadic presentation, clinical anomalies, and breech presentation predicted PSIS at presentation. Breech presentation in PSIS is likely due to stalk interruption rather than hormonal deficiency.
Synthesis of Silver Nanoparticles Reduced by Bingol Propolis and Evaluation of Antioxidant, Cytotoxic and Anticancer Activities in PC-3 Cells
Authors: Dervişoğlu Gökhan , Darendelioğlu Ekrem , Aykutoğlu Gürkan , Ayna Adnan , KAYA BÜLENT 
Published: March 2022

Abstract
Green synthesis of silver nanoparticles (AgNPs) has been reported in several studies. However, no study focused on synthesis, characterization, and investigation of anticancer and antioxidant activities of AgNPs using Bingöl propolis. The morphology and physical properties of PrAgNPs (propolis-AgNPs) were characterized by UV-Vis spectrum of the characteristic silver surface plasmon resonance band, FTIR, XRD, SEM, zeta potential and DLS analysis. XRD and zeta potential analysis revealed a potential of-24.6 mV and formation of cubic crystals, with an average size of 3.45 nm, and a wide band at 420 nm was detected in UV-vis spectroscopy. The in vitro antioxidant capacities of PrAgNPs were evaluated by DPPH radical scavenging, metal chelating, and hydroxyl radical scavenging activities. The cytotoxicity and anticancer activities of ethanolic extract of propolis (EEP) and PrAgNPs were investigated on PC-3 cell lines by WST-1 assay and western blotting. The results demonstrated that PrAgNPs showed higher antioxidant activity than the EEP. The synthesized PrAgNPs were also shown to inhibit PC-3 cell proliferation. In the immunoblotting study, the expression of levels of apoptotic markers pro-caspase-3 and cytochrome c confirmed apoptosis induced by PrAgNPs. The current study reveals that green synthesized PrAgNPs possess antioxidant, anticancer, and apoptotic activities on human prostate cancer cell line PC-3 and pave the way for the possible treatment of the various cancers.
Measurement error risk for finger-cuff blood pressure after aortic valve replacement are aortic valve area index and heart rate; FloTrac vs ClearSight
Authors: Yahagi Musashi , Sasaki Momoko , Omi Kyuma , Tabata Koya , Yaguchi Yuichi 
Published: March 2022

Abstract
Purpose: The accuracy of ClearSightTM blood pressure measurements in patients with postaortic valve replacement may be inaccurate compared to intra-arterial pressure, the clinical risk of measurement discrepancy remains uncertain. This study aimed to determine the factors associated with errors in measurement. Methods: From October 2020 to November 2021, we collected 881 pairs of intra-arterial/ClearSight blood pressure measurements from 30 adults who underwent transcatheter aortic valve replacement. The agreement of ClearSight blood pressure with intra-arterial pressure was compared, and the clinical risk was evaluated by classifying measurement errors into zones A (no risk) to E (dangerous risk) using error grid analysis. Results: The bias and precision of ClearSight measurement were −4.88 ± 15.46 (mmHg) for systolic, 4.73 ± 8.95 (mmHg) for the mean and 9.53 ± 9.01 (mmHg) for the diastolic blood pressure. The proportions of measurement pairs in zones A were 88.0% for systolic BP and 71.2% for mean BP, respectively. Logistic regression analysis revealed that the risk of measurement error being outside zone A was heart rate [odds ratio, 1.24; 95% confidence interval, 1.15 to 1.35; p<0.001] for systolic and mean blood pressure, and aortic valve area index < 1.0 (cm2. m−2) [odds ratio, 1.62; 95% confidence interval, 1.21 to 2.16; p=0.02] for mean blood pressure.Conclusion: These findings could help to identify patients of unsuitable for ClearSight blood pressure measurement. Our results demonstrate that the small aortic valve area index and low cardiac index are risk factors for measurement error.
Comparative Analysis of Bioaccumulation of Cadmium, Lead, Chromium, Copper and Nickel in Wheat Crop
Authors: mazhar muhammad waqar , Irfan Muhammad , SAIF SAIRA , irum wajeeha 
Published: March 2022

Abstract
In this research, the comparative analysis of heavy metals has been studied. An experiment was conducted to determine heavy metals bioaccumulation in wheat as wheat is the staple cereal crop consumed as food globally. Abiotic stress disturbs the metabolic pathway of plants, and the bioaccumulation of the metals cause enzymatic degradation, reduction in photosynthesis, increased level of the ROS species. Comparative analysis of the Cd, Pb, Cr, Cu, and Ni was analyzed with the help of Inductively Coupled plasma optical emission spectrometry (ICP-OES). The results show that Ni has a maximum value of BCF in shoots and roots, whereas the Cr has maximum TF values. SOD and POD assays were performed to check the ROS level in the plants. The results show that plants increase their anti-oxidant enzymes for the scavenging of ROS produced against the bioaccumulation of heavy metals.
Time is of the essence: Past selves are not prioritized even when selective discrimination costs are controlled for
Authors: Englert Julia , von Lampe Karola , Morina Nexhmedin 
Published: March 2022

Abstract
The perceptual Self Prioritization effect (SPE) refers to an advantage in attending to stimuli associated with the self relative to those associated with another individual. In the perceptual matching task, arbitrary pairings between oneself and other persons, and a geometric shape need to be learned. Apart from the SPE, this task also produces high matching performance for a close other. While cognitive representations of past selves are sometimes viewed as resembling that of an intimate other, and while there is some evidence that other types of psychological closeness modulate the SPE, it remains unclear whether such prioritization effects extend to past selves. Previous experiments on this topic required participants to distinguish between different points in time within the same task, raising the possibility that potential past self-prioritization was masked by task difficulty. In our experiment, we address this potential confound by presenting N = 118 participants with a simpler version of the matching task. We re-investigated self-prioritization in perceptual matching under conditions of mental time travel to the past. In line with previous evidence, we found clear prioritization of present selves, which was evident in response times, accuracies and the efficiency of practice. Performance was consistently poorest for the past self, indicating not only a lack of privileged processing, but rather a relative de-prioritization. Performance was unaffected by either the proximity of the time period in question, nor by experimenter-induced re-imagining of the self. Our results do not support a perceptual prioritization of past selves. Time is of the essence: Past selves are not prioritized even when selective discrimination costs are controlled for
A New Paradigm Shift in Antidepressant Therapy: From Dual-action
to Multitarget-directed Ligands
Authors: Rodríguez-Lavado Julio , Alarcón-Espósito Jazmín , Mallea Michael , Lorente Alejandro 
Published: March 2022

Abstract:
Major Depressive Disorder is a chronic, recurring, and potentially fatal disease,
affecting up to 20% of the global population. Since the monoamine hypothesis was
proposed more than 60 years ago, only a few relevant advances have been made, with
very little disease course changing from a pharmacological perspective. Moreover, since
the negative efficacy of novel molecules is frequently reported in studies, many pharmaceutical
companies have put new studies on hold. Fortunately, relevant clinical studies
are currently being performed extensively, developing immense interest among universities,
research centers, and other public and private institutions. Depression is no longer
considered a simple disease but a multifactorial one. New research fields are emerging,
occurring a paradigm shift, such as the multi-target approach beyond monoamines. In
this review, we summarize antidepressant drug discovery aiming to shed some light on
the current state-of-the-art clinical and preclinical advances to face this increasingly devastating
disease.
Could Polyphenolic Food Intake Help in the Control of Type 2 Diabetes?
A Narrative Review of the Last Evidence
Authors: D'Angelo Stefania , Ferrara Luigi , Joksimovic Marko 
Published: March 2022

Background:
Diabetes is one of the most serious global public health concerns, imposing
a significant burden on public health and socio-economic development, with type 2 diabetes
accounting for 90 percent of individuals with the disease (T2D).

Introduction:
Beyond the hereditary factor, there are several risk factors associated with the
development of this syndrome; the lifestyle plays an increasingly predominant role in the development
of the metabolic complications related to T2D and a significant role in the onset of this
syndrome is played by an unbalanced diet. Polyphenolic food is a plant-based food, including
vegetables, fruits, whole grains, tea, coffee, and nuts. In recent years, there has been growing evidence
that polyphenols, due to their biological properties, may be used as nutraceuticals and
supplementary treatments for various aspects of T2D. Polyphenols may influence glycemia and
T2D through hypoglycemic properties, such as reduced insulin resistance, reduced fasting blood
glucose, and glycosylated hemoglobin value. Based on several in vitro, animal models, and some
human studies, it has been detected that polyphenol-rich products modulate carbohydrate and lipid
metabolism, attenuate hyperglycemia, dyslipidemia, and insulin resistance, improve adipose
tissue metabolism, and alleviate oxidative stress and stress-sensitive signaling pathways and
inflammatory processes.

Methods:
This manuscript summarizes human clinical trials conducted within the last 5 years
linking dietary polyphenols to T2D, with a focus on polyphenolic foods found in the Mediterranean
diet.

Results:
Intaking polyphenols and their food sources have demonstrated beneficial effects on insulin
resistance and other cardiometabolic risk factors. Prospective studies have shown inverse
associations between polyphenol intake and T2D. The Mediterranean diet and its key components,
olive oil, nuts, and red wine, have been inversely associated with insulin resistance and
T2D.

Conclusion:
In conclusion, the intake of polyphenols may be beneficial for both insulin
resistance and T2D risk. However, other human clinical studies are needed to evaluate the
suitable dose and duration of supplementation with polyphenolic food in T2D patients.
Drug Repurposing Strategies for Non-cancer to Cancer Therapeutics
Authors: Singhal Shipra , Maheshwari Priyal , Krishnamurthy Praveen Thaggikuppe , Patil Vaishali M. 
Published: March 2022

Abstract:
Global efforts invested in the prevention and treatment of cancer need to be repositioned to develop safe,
effective, and economic anticancer therapeutics by adopting rational approaches of drug discovery. Drug repurposing is
one of the established approaches to reposition old, clinically approved off-patent noncancer drugs with known targets
into newer indications. The literature review suggests a key role of drug repurposing in the development of drugs intended
for cancer as well as noncancer therapeutics. A wide category of noncancer drugs such as, drugs acting on CNS,
anthelmintics, cardiovascular drugs, antimalarial drugs, anti-inflammatory drugs, have come out with interesting outcomes
during preclinical and clinical phases. In the present article, a comprehensive overview of the current scenario
of drug repurposing for the treatment of cancer has been focused. The details of some successful studies along with
examples have been included followed by associated challenges.