bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mercury–Selenium Accumulation Patterns in Muscle Tissue of Two Freshwater Fish Species, Eurasian Perch (Perca fluviatilis) and Vendace (Coregonus albula)
Authors: Regnell Olof , Tesson Sylvie V. M. , Oskolkov Nikolay , Nerentorp Michelle 
Published: June 2022

Abstract
Mercury (Hg) in the form of highly toxic methyl mercury (MeHg) accumulates in aquatic food webs to an extent where it may threaten fish health in many freshwaters. Selenium (Se) mitigates the toxicity of accumulated Hg by forming strong bonds with it, a drawback being diversion of Se from biosynthetic pathways of essential selenoenzymes. We measured Se and Hg in muscle tissue of Eurasian perch (Perca fluviatilis) and vendace (Coregonus albula). For the perch, Se and Hg correlated positively. For the vendace, a positive relationship was seen when the effect of fish size was accounted for. All fish displayed surplus Se (mol Se – mol Hg > 0). For both fish species, the Se molar surplus ((nmol Se – nmol Hg)/g ww) decreased with fish weight. It was higher in the perch than in the vendace and showed the least variation among the small perch (4–34 g). For the large perch (79–434 g), the Se molar surplus decreased with increasing Hg below 0.5 µg Hg but then increased with further Hg increment despite Hg being a negative term in the Se molar surplus. In case the Se molar surplus reflected the weight-specific Se requirement, the latter clearly decreased with increasing fish size for the vendace. This was less clear for the perch because of the strong correlation between Hg and weight. Together, these Se–Hg relationships suggest that Se accumulation was at least partly subject to homeostatic control and responded to the Hg body burden and the Se requirement.
Graphical abstract
Antifungal effect of triclosan on Aspergillus fumigatus: quorum quenching role as a single agent and synergy with liposomal amphotericin-B
Authors: Tamimi Roya , Kyazze Godfrey , Keshavarz Tajalli 
Published: June 2022

AbstractThe purpose of this research was to determine Aspergillus fumigatus conidial viability and its biofilm formation upon treatment with triclosan and amphotericin-B loaded liposomes. A. fumigatus was treated with the antimicrobials, triclosan and liposomal amphotericin-B (L-AMB), in single and combined supplementation. To quantify the cells’ viability upon treatments, resazurin-based viability assay was performed. Confocal laser scanning microscopy was done by applying FUN-1 stain to screen the role of the agents on extracellular polymeric substances. Total A. fumigatus biomass upon treatments was estimated by using crystal violet-based assay. To study the agents’ effect on the conidial viability, flow cytometry analysis was performed. Expression levels of A. fumigatus genes encoding cell wall proteins, α-(1,3)-glucans and galactosaminogalactan were analysed by real-time polymerase chain reaction assay. A synergistic interaction occurred between triclosan and L-AMB when they were added sequentially (triclosan + L-AMB) at their sub-minimum inhibitory concentrations, the triclosan and L-AMB MICs were dropped to 0.6 and 0.2 mg/L, respectively, from 2 to 1 mg/L. Besides, L-AMB and triclosan contributed to the down-regulation of α-(1,3)-glucan and galactosaminogalactan in A. fumigatus conidia and resulted in less conidia aggregation and mycelia adhesion to the biotic/abiotic surfaces; A. fumigatus conidia-became hydrophilic upon treatment, as a result of rodlet layer being masked by a hydrophilic layer or modified by the ionic strength of the rodlet layer. In A. fumigatus, the potential mechanisms of action for L-AMB might be through killing the cells and for triclosan through interrupting the cells’ development as a consequence of quorum quenching.
Evaluation verhaltenspräventiver Gesundheitsförderungsmaßnahmen in Inklusionsbetrieben
Authors: Efimov Ilona , Tell Anika , Kordsmeyer Ann-Christin , Harth Volker , Mache Stefanie 
Published: June 2022

Zusammenfassung
Hintergrund
Inklusionsbetriebe nach §§ 215–218 SGB IX bieten schwerbehinderten Menschen eine Beschäftigung auf dem allgemeinen Arbeitsmarkt. Seit 2018 sind Inklusionsbetriebe verpflichtet, Maßnahmen der betrieblichen Gesundheitsförderung (BGF) anzubieten.

Ziel der Arbeit
Das Ziel der vorliegenden Studie ist es, verhaltenspräventive BGF-Angebote in Form von Seminaren für schwerbehinderte Beschäftigte und deren Leitungskräfte in Inklusionsbetrieben zu evaluieren.

Material und Methoden
Anhand eines multimethodischen Studiendesigns erfolgte im Zeitraum von Juni bis November 2021 eine Evaluation der 12 Beschäftigtenseminare (3 Seminarkonzepte, z. B. Selbstfürsorge im Arbeitsalltag) mittels Fokusgruppen (n = 44) und eine Evaluation der 3 Leitungskräfteseminare zur gesunden Führung mittels eines standardisierten Fragebogens (n = 10). Die erhobenen quantitativen Daten wurden deskriptiv ausgewertet und die qualitativen Daten mithilfe der qualitativen Inhaltsanalyse nach Mayring induktiv analysiert.

Ergebnisse
Die Ergebnisse zeigten, dass die durchgeführten Maßnahmen zur BGF von Beschäftigten hinsichtlich der Zufriedenheit, der Seminarlänge, der Verständlichkeit und des erwarteten Nutzens mehrheitlich positiv bewertet wurden. Die Leitungskräfte bewerteten die Seminarinhalte, die Didaktik, die Seminarleitung und den Beitrag der Teilnehmenden mehrheitlich positiv.

Diskussion
Die Studie lieferte erste empirische Erkenntnisse zur Evaluation von BGF-Maßnahmen in Inklusionsbetrieben. Vor allem die auf die Inklusionsbetriebe angepassten Seminarinhalte konnten die Zufriedenheit der Teilnehmenden mit der Gesundheitsförderungsmaßnahme positiv beeinflussen. Insgesamt bedarf es weiterer Studien zur Entwicklung und Evaluation von verhältnis- und verhaltensbezogenen BGF-Maßnahmen in Inklusionsbetrieben.
How ecovillages work: more-than-human understandings of rentabilidad in Mexican ecovillages
Authors: Morris Olea 
Published: June 2022

AbstractThis article highlights the emergence of intentional communities known as ecovillages (ecoaldeas) in Mexico, exploring how humans seek to design sustainable futures in part by re-making rural livelihoods. Ecovillages are inherently speculative ventures, or as Burke and Arjona (2013) note, laboratories for alternative political ecologies, inviting—and indeed, necessitating—the reimagination of human lives with greater consideration for the natural world. In this sense, such communities might be understood as “exilic spaces” (O’Hearn and Grubačić 2016), in that they seek to build autonomous and self-sustaining agricultural, social, and economic systems while also reflecting a stance of resistance to neoliberal capitalist structures. At the same time, communities may also remain dependent on connections to broader regional or global markets in diverse and interconnected ways. Understanding ecovillages as diverse and emergent “worldings” (de la Cadena and Blaser 2018), I ask how these experimental social ventures reckon with their connections to the very systems they are positioned against. To trace out how communities negotiate this fragile space, this article is concerned with how ecovillagers spend their time at work—particularly when it comes to managing relationships with and between more-than-human beings. Drawing on participant observation with ecovillagers and more-than-human others they work with, I explore how the concept of “rentabilidad” (profitability) is differently constructed. To this end, I highlight ethnographic examples whererentabilidadis purposefully reconceptualized with more-than-human lives in mind; such a shift, I suggest, hinges on ecovillagers’ individualized relations with the beings they (imagine themselves) to care for.
Intra-abdominal Bleeding due to Segmental Arterial Mediolysis and Coexisting Pulmonary Thromboembolism: a Case Report
Authors: Togawa Yuki , Matsushime Susumu , Tamura Nobuichiro , Kawamoto Kazuyuki 
Published: June 2022

Abstract Segmental arterial mediolysis (SAM) is a rare but important cause of abdominal haemorrhage and is usually treated with endovascular management. Surgical or conservative management can be performed depending on the patient’s situation. Since the course of conservative treatment is not well described in the existing literature, it must be used with caution. We describe the case of a 52-year-old man who was transferred to the emergency department because of abdominal pain, diarrhoea, and haematemesis. On arrival, he was haemodynamically unstable, with a blood pressure of 70/40 mmHg. After he was transfused and stabilised in the emergency department, contrast-enhanced computed tomography (CECT) revealed a haematoma around the transverse colon and ascites, without any evident extravasation. The peripheral branch of the middle colic artery (MCA) showed irregular calibre, suggesting SAM. Since the patient remained stable, we initially chose conservative management. However, a CECT scan performed on the third day of hospitalisation showed coexisting pulmonary thromboembolism (PTE). Because of the need for anticoagulation therapy, we performed open surgery. The pathological examination was consistent with SAM. Anticoagulation therapy was initiated the next day. A CECT scan performed on a postoperative day (POD) 13 showed no PTE. Although the patient defecated haemorrhagic stool and experienced hematemesis on PODs 19 and 23, respectively, colonoscopy, esophagogastroduodenoscopy, and repeated CECT scans revealed no evidence of rebleeding, and no recurrence was observed. Open surgery produced a relatively good postoperative course for the patient. Endovascular management, however, remains a reasonable first approach, considering its reportedly excellent outcomes.
Temporal Changes in Mindfulness Skills and Positive and Negative Affect and Their Interrelationships During Mindfulness-Based Cognitive Therapy for Cancer Patients
Authors: Cillessen Linda , Van de Ven Monique O. M. , Burk William. J. , Bisseling Else M. , Compen Félix R. , Van der Lee Marije L. , Speckens Anne E. M. 
Published: June 2022

Abstract

Objectives

While efficacy research on mindfulness-based interventions in cancer patients is available, research on possible mechanisms of change is lacking. The current study investigated general and week-to-week changes and interrelations in mindfulness and positive and negative affect in Mindfulness-Based Cognitive Therapy (MBCT) for cancer patients.

Methods
In total, 163 cancer patients completed face-to-face or online MBCT. Mindfulness and positive and negative affect were measured weekly during the intervention. Autoregressive latent trajectory models were used to evaluate general and week-to-week effects.

Results
Overall, mindfulness and positive affect increased, and negative affect decreased during MBCT. Higher general levels of mindfulness were associated with higher general levels of positive affect. Regarding week-to-week effects, positive affect in weeks 3, 7, and 8 predicted an increase in mindfulness in the following week. Various general relations were observed between mindfulness and negative affect, showing that higher mindfulness was related to less negative affect. To the contrary, week-to-week effects showed higher mindfulness consistently predicted increased negative affect in the subsequent week.

Conclusions
In cancer patients, mindfulness appeared to be more robustly related to negative than to positive affect. Furthermore, mindfulness in one week was related to an increase of negative affect in the following week, possibly due to turning towards previously suppressed negative emotions. However, when focusing on the whole course from start to end, the increase of mindfulness was related to a decrease of negative affect, possibly due to acceptance of and exposure to negative emotions. Our findings reveal the complexity of mechanisms of MBCT and illustrate the necessity of sophisticated models with longitudinal measurements to truly elucidate these mechanisms.

Trial Registration
Clinical Trials.gov: NCT02138513.
A distributional approach to fractional Sobolev spaces and fractional variation: asymptotics I
Authors: Comi Giovanni E. , Stefani Giorgio 
Published: June 2022

AbstractWe continue the study of the space $$BV^\alpha ({\mathbb {R}}^n)$$BVα(Rn)of functions with bounded fractional variation in $${\mathbb {R}}^n$$Rnof order$$\alpha \in (0,1)$$α∈(0,1)introduced in our previous work (Comi and Stefani in J Funct Anal 277(10):3373–3435, 2019). After some technical improvements of certain results of Comi and Stefani (2019) which may be of some separated insterest, we deal with the asymptotic behavior of the fractional operators involved as$$\alpha \rightarrow 1^-$$α→1-. We prove that the$$\alpha $$α-gradient of a$$W^{1,p}$$W1,p-function converges in$$L^p$$Lpto the gradient for all$$p\in [1,+\infty )$$p∈[1,+∞)as$$\alpha \rightarrow 1^-$$α→1-. Moreover, we prove that the fractional$$\alpha $$α-variation converges to the standard De Giorgi’s variation both pointwise and in the$$\Gamma $$Γ-limit sense as$$\alpha \rightarrow 1^-$$α→1-. Finally, we prove that the fractional$$\beta $$β-variation converges to the fractional$$\alpha $$α-variation both pointwise and in the$$\Gamma $$Γ-limit sense as$$\beta \rightarrow \alpha ^-$$β→α-for any given$$\alpha \in (0,1)$$α∈(0,1).
A review of recent advances in engineering bacteria for enhanced CO2 capture and utilization
Authors: Onyeaka H. , Ekwebelem O. C. 
Published: June 2022

AbstractCarbon dioxide (CO2) is emitted into the atmosphere due to some anthropogenic activities, such as the combustion of fossil fuels and industrial output. As a result, fears about catastrophic global warming and climate change have intensified. In the face of these challenges, conventional CO2 capture technologies are typically ineffective, dangerous, and contribute to secondary pollution in the environment. Biological systems for CO2 conversion, on the other hand, provide a potential path forward owing to its high application selectivity and adaptability. Moreover, many bacteria can use CO2 as their only source of carbon and turn it into value-added products. The purpose of this review is to discuss recent significant breakthroughs in engineering bacteria to utilize CO2 and other one-carbon compounds as substrate. In the same token, the paper also summarizes and presents aspects such as microbial CO2 fixation pathways, engineered bacteria involved in CO2 fixation, up-to-date genetic and metabolic engineering approaches for CO2 fixation, and promising research directions for the production of value-added products from CO2. This review's findings imply that using biological systems like modified bacteria to manage CO2 has the added benefit of generating useful industrial byproducts like biofuels, pharmaceutical compounds, and bioplastics. The major downside, from an economic standpoint, thus far has been related to methods of cultivation. However, thanks to genetic engineering approaches, this can be addressed by large production yields. As a result, this review aids in the knowledge of various biological systems that can be used to construct a long-term CO2 mitigation technology at an industrial scale, in this instance bacteria-based CO2capture/utilization technology.
Hypoglycaemic therapy in frail older people with type 2 diabetes mellitus—a choice determined by metabolic phenotype
Authors: Sinclair Alan J. , Pennells Daniel , Abdelhafiz Ahmed H. 
Published: June 2022

AbstractFrailty is a newly emerging complication of diabetes in older people and increasingly recognised in national and international clinical guidelines. However, frailty remains less clearly defined and frail older people with diabetes are rarely characterised. The general recommendation of clinical guidelines is to aim for a relaxed glycaemic control, mainly to avoid hypoglycaemia, in this often-vulnerable group of patients. With increasing age and development of frailty, body composition changes are characterised by an increase in visceral adipose tissue and a decrease in body muscle mass. Depending on the overall body weight, differential loss of muscle fibre types and body adipose/muscle tissue ratio, the presence of any associated frailty can be seen as a spectrum of metabolic phenotypes that vary in insulin resistance of which we have defined two specific phenotypes. The sarcopenic obese (SO) frail phenotype with increased visceral fat and increased insulin resistance on one side of spectrum and the anorexic malnourished (AM) frail phenotype with significant muscle loss and reduced insulin resistance on the other. In view of these varying metabolic phenotypes, the choice of hypoglycaemic therapy, glycaemic targets and overall goals of therapy are likely to be different. In the SO phenotype, weight-limiting hypoglycaemic agents, especially the new agents of GLP-1RA and SGLT-2 inhibitors, should be considered early on in therapy due to their benefits on weight reduction and ability to achieve tight glycaemic control where the focus will be on the reduction of cardiovascular risk. In the AM phenotype, weight-neutral agents or insulin therapy should be considered early on due to their benefits of limiting further weight loss and the possible anabolic effects of insulin. Here, the goals of therapy will be a combination of relaxed glycaemic control and avoidance of hypoglycaemia; and the focus will be on maintenance of a good quality of life. Future research is still required to develop novel hypoglycaemic agents with a positive effect on body composition in frailty and improvements in clinical outcomes.
System dynamics model: developing model for supplier selection with a focus on CSR criteria
Authors: Liu Peide , Hendalianpour Ayad , Hafshejani Mitra Forouzandeh , Yaghoobi Farideh , Feylizadeh Mohammdreza 
Published: June 2022

AbstractThe complexity and significance of decision-making in selecting suppliers highlight the need for a systematic and transparent approach. The more organizations rely on suppliers, the more harmful the direct and indirect consequences of poor decision-making are. This study attempted to identify factors affecting supplier selection and develop a system dynamics model for supplier selection by taking into account social corporate responsibility (CSR) practices. This model aims to increase CSR practices when selecting suppliers and thus help supply chain members gain competitive power and satisfy customer demands optimally. The system dynamics model for supplier selection was developed by considering profitability, productivity, social transparency, and customer satisfaction. To this end, first, the indicators affecting supplier selection were identified. Then, a cause–effect model was extracted by surveying subject-matter experts. Finally, the system dynamics model was developed. The final output of the third stage was a dynamic model of a supplier selection system that considers CSR practices. The results showed that profitability increases only by implementing the policy of reducing the average distance between suppliers and increasing the number of suppliers. This issue causes lower costs, reduced delivery time due to reduced average distance between suppliers, and increased suppliers, resulting in increased customer satisfaction and increased demand.
Improving primary STEM education by integrating the Australian Curriculum
Authors: Jacobs Brendan 
Published: June 2022

AbstractA report commissioned by the Australian Council of Educational Research in 2018 titled Challenges in STEM learning in Australian schools: Literature and policy review found that the Australian Curriculum is packaged in discrete disciplines and is not future facing. It concluded that “the goal is to see students working in an integrative way” (Timms et al. Australian Council for Educational Research, 2018, p. 2). Accordingly, this paper reports on the first phase of a design-based research (DBR) project which integrates learning around 28 specific learning outcomes from the existing Australian Curriculum. The hypothesis presented is that students and teachers can expand their knowledge and skills in STEM by having a daily STEM focus built into each day. As a longitudinal study, this paper reports on the initial planning and findings which continue to refine the theoretical assumptions of the DBR methodology. Given that the consultation phase of a major review of the Australian Curriculum ended on 8 July 2021, these insights also capture a pivotal moment in time. The three emergent themes which were evident across the 28 STEM units have the potential to collectively signal the essence and future direction of STEM education, namely science inquiry skills, data and variables, and design.
Technology development for the early detection of plant pests: a framework for assessing Technology Readiness Levels (TRLs) in environmental science
Authors: White Rehema , Marzano Mariella , Fesenko Elena , Inman Alan , Jones Glyn , Agstner Barbara , Mumford Rick 
Published: June 2022

AbstractInnovation in environmental fields such as plant health is complex because of unbounded challenges and lack of certainty of commercial uptake. In this paper we present a Technology Readiness Level (TRL) framework, specifically to assist with assessment of technologies to support detection of tree pests and pathogens, but also for wider potential adaptation. Biosecurity can be enhanced by improved early detection of pests and pathogens, but development and deployment of new technologies requires robust scrutiny. We critically analyse the concept, practice and applicability of TRLs. Interviews revealed scientist perspectives during the development process of five novel early plant pest and pathogen detection technologies. A retrospective, collective narrative of one technology from concept to commercial deployment was undertaken. We then developed a calculator tool for assessment of biosecurity TRLs. Our findings illustrate the iterative process of technology development, the challenges in final TRLs of acquiring funding to move from proven success to viable product, inefficiencies created through the need for multiple projects for each technology and the imperative to consider the wider socio-ecological technical landscape, including policy context. End user engagement was particularly valuable at beginning and end of the TRL scale. We conclude that the TRL framework comprises a robust approach to assess technologies in that it facilitates progress tracking, evaluation of success likelihood and identification of opportunities for investment. However, its potential will only be realised for environmental management if it is integrated into the socio-ecological technical landscape and wider discussions regarding knowledge co-production and valuing nature.
Is a Minimal Federal European Constitution for the European Union Necessary? Some Preliminary Suggestions Using Public Choice Analysis
Authors: Schneider Friedrich 
Published: June 2022

Abstract
After overcoming the Coronavirus Pandemic with massive spending programs and the possibility of running a deficit at the EU level, a minimal Federal European Constitution is proposed, to provide a legal and democratic base for the European Union. Six basic elements of a future European federal constitution are developed: the European Commission should be turned into a European government and the European legislation should consist of a two-chamber system with full responsibility over all federal matters. Three further key elements are the subsidiarity principle, federalism and direct democracy, which would provide the possibility for European voters to participate actively in political decision making, to break political and interest group cartels, and to prevent unwanted shifting of responsibilities from EU member states to the European federal level.