bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatosplenic mucormycosis due to Rhizomucor pusillus identified by panfungal PCR/sequencing of ribosomal ITS2 and LSU regions in a patient with acute myelogenous leukemia: A case report
Authors: Gillrie Mark , Chow Barbara , Griener Thomas , Johnson Andrew , Church Deirdre 
Published: October 2022

Background: Angioinvasive Rhizomucor pusillus infection with dissemination to the liver and spleen is exceedingly uncommon, representing less than 1% of reported cases of mucormycosis. Methods: Diagnosis of mucormycosis is often difficult using conventional methods that rely on broad-based non-septate hyphae present on histologic examination and morphological identification of the cultured organism. Our laboratory also uses an in-house panfungal molecular assay to rapidly diagnose invasive fungal infection when conventional methods do not provide definitive results. Results: Herein we present a case of disseminated mucormycosis with hepatosplenic involvement in a 49-year-old female with acute myelogenous leukemia following induction chemotherapy. But in this case repeated tissue biopsy cultures were negative. R. pusillus infection was diagnosed using an in-house panfungal PCR/sequencing assay based on dual priming oligonucleotide primers. Conclusions: New molecular assays facilitate prompt diagnosis of invasive fungal infections.
HUBUNGAN PENGETAHUAN DENGAN SIKAP IBU DALAM MEMBERIKAN STIMULASI TUMBUH KEMBANG PADA BALITA USIA 1-3 TAHUN
Authors: Puspitasari Betristasia , Herdyana Erma 
Published: October 2022

Pendahuluan: Stimulasi merupakan salah upaya untuk mencerdaskan anak. Kurangnya pengetahuan dan keterampilan ibu dapat menyebabkan penyimpangan perkembangan pada anak. Tujuan penelitian ini adalah untuk mengetahui hubungan pengetahuan dengan sikap ibu dalam memberikan stimulasi tumbuh kembang pada balita usia 1-3 tahun. Metodologi : Metodologi penelitian desain penelitian korelasi dengan pendekatan cross sectional. Populasi penelitian ini adalah semua ibu yang mempunyai anak usia 1-3 tahun di RW 02 Desa Sidomulyo Kec. Semen Kab. Kediri sebanyak 32 orang. Teknik sampling dengan total sampling. Variabel independennya adalah pengetahuan ibu tentang stimulasi tumbuh kembang pada balita usia 1-3 tahun dan variabel dependen adalah Sikap ibu dalam memberikan stimulasi tumbuh kembang pada balita usia 1-3 tahun. Pengumpulan data menggunakan kuesioner, pengolahan data editing, coding, scoring dan tabulating. Analisa data menggunakan chi kuadrat. Hasil : Hasil penelitian dari uji analis Chi Kuadrat didapatkan nilai x^2 hitung = 7,649 dan x^2 tabel = 5,991 dengan taraf signifikan 5 %. Jadi x^2 hitung > x^2 tabel. Ho ditolak dan H1 di terima, artinya ada hubungan. Kesimpulan : Dapat disimpulkan bahwa ada hubungan pengetahuan dengan sikap ibu dalam memberikan stimulasi tumbuh kembang pada balita usia 1-3 tahun. Petugas kesehatan seharusnya lebih meningkatkan pengetahuan ibu agar lebih baik. Apabila pengetahuan baik, sikap ibu dalam memberikan stimulasi tumbuh kembang juga akan meningkat sehingga tumbuh kembang balita berjalan secara optimal.

Kata kunci	:	Pengetahuan, sikap, ibu, stimulasi tumbuh kembang, balita usia 1-3 tahun
A A Biological-Inspired Cryptosystem based on DNA Cryptography and Morse Code Ciphering Technique
Authors: B Adithya , G Santhi 
Published: October 2022

Due to its prominent facility to hide colossal datasets with a high calibre of randomness and subsequent protection, the famous genomic Deoxyribonucleic Acid (DNA) has been presented as a hiding medium, known as DNA steganography. An incipient information-securing technique using the organic DNA structure called DNA Computing was introduced. In this paper, cryptosystem based DNA computation and Morse code cipher is proposed to bulwark the delicate knowledge within the demanding environment. The plaintext is changed over to DNA sequences utilising the encoding table. The encoded information is actually transcribed and translated by the Ribonucleic Acid (RNA) arrangements. Translated RNA is stego by the standard genetic code utilising organic compounds, and the stego DNA is ciphered by Morse code pattern. Avalanche Effect achieves 96.86% bits of average changes occurred in ciphertext. Therefore, the proposed cryptosystem shows strong randomisation and provides complex mapping between plaintext and ciphertext. Also, the designed bio explores analysis and results shows that the security of the transmission is high, and it preserves the biological process.
Наукова діяльність ДНТЦ ЯРБ у 2017 – 2021 роках
Authors: Valigun N. , Vorobey I. , Korniievska O. , Andriushko Yu. , Pecherytsia O. 
Published: October 2022

Основними завданнями наукової діяльності ДНТЦ ЯРБ є: одержання конкурентоздатних наукових і науково-прикладних результатів для вирішення пріоритетних завдань з науково-технічної, експертної та інформаційно-аналітичної підтримки державного органу регулювання ядерної та радіаційної безпеки України; аналіз існуючої системи нормування з метою виявлення неврегульованих аспектів, невизначеностей та протиріч; вивчення та аналіз досвіду експлуатації ядерних установок; вивчення, адаптація та запровадження в практику передових методологій виконання аналізу та оцінки безпеки; освоєння сучасних розрахункових кодів і розроблення моделей для отримання знань про перебіг процесів у компонентах реакторної установки і гермооб'ємі, популяризація наукових досягнень підприємства та надання освітніх послуг, направлених на підвищення професійної кваліфікації та професійної перепідготовки спеціалістів та фахівців у сфері використання ядерної енергії, організація видавничої діяльності тощо.
У статті зазначені основні результати наукової діяльності підприємства за 2017 – 2021 роки, зокрема: описані результати досліджень за напрямами: аналіз досвіду експлуатації ядерних установок, інтегральна система нагляду за безпекою АЕС, аварійна готовність і реагування, поводження з радіоактивними відходами, розглянуто досвід підприємства з розроблення розрахунковий моделей, які дозволяють досліджувати процеси в реакторних установках енергоблоків усіх типів, що експлуатуються на АЕС України, описані напрями освітньої та науково-інформаційної діяльності як у межах України, так і за кордоном.
Науково-дослідні та аналітичні роботи є основою формування науково-технічного потенціалу ДНТЦ ЯРБ, удосконалення розрахунково-аналітичних можливостей та дослідження актуальних питань безпеки використання ядерної енергії. Для підтримки належного рівня компетенції ДНТЦ ЯРБ співпрацює з провідними національними науковими та міжнародними організаціями й установами з метою вироблення єдиних наукових і методичних підходів до ядерної та радіаційної безпеки, обміну науковою інформацією.
Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics
Authors: Zhou Yang , Wang Ronghui , Teng Zhaogang , Wang Zhigang , Hu Bing , Kolios Michael , Chen Hangrong , Zhang Nan , Wang Yanjie , Li Pan , Wu Xing , Lu Guangming , Chen Yu , Zheng Yuanyi 
Published: October 2022

<p>The development of efﬁcient strategies for in vivo stimuli-responsive cancer treatment and personalized biomedicine is a great challenge. To overcome the critical issues and limitations of traditional protocols using acoustic droplet vaporization and optical droplet vaporization in stimuli-responsive tumor treatment, we herein report a new strategy, magnetic droplet vaporization (MDV), based on nanobiotechnology, for efﬁcient magnetic ﬁeld-responsive cancer theranostics. Perﬂuorohexane (PFH)-encapsulated superparamagnetic hollow iron oxide nanoparticles with a high magnetic-thermal energy transfer capability quickly respond to an external alternating current (a.c.) magnetic ﬁeld to produce thermal energy and raise the temperature of the surrounding tumor tissue. The encapsulated PFH, with a desirable boiling point of ~56°C, can be vaporized to enhance the performance of ultrasound imaging of tumors, as systematically demonstrated both in vitro and in vivo. The magnetic–thermal energy transfer further ablated and removed tumors in mice tumor xenograft models. This unique MDV principle with high versatility and performance is expected to broaden the biomedical applications of nanotechnology and promote clinical translations of intelligent diagnostic and therapeutic modalities, especially for battling cancer. </p>
Evaluation of Employee Acceptance of the IMS Application at PT Sarana Utama Adimandiri: TAM Approach
Authors: Sancoko Sancoko , Prayogi Zahra Shalsabilla , Al Aufa Badra , Yuliawan Rahmat 
Published: October 2022

PT Sarana Utama Adimandiri (SUA) which is engaged in the construction sector implements an IMS application in its purchasing activity. This paper aims at describing the evaluation of employee acceptance of the information system at PT SUA using the Technology Acceptance Model (TAM) approach. TAM has two main variables i.e: perceived usefulness and perceived ease of use which function as independent variables, while the dependent variable is acceptance of IT (integrated management system/IMS applications). The population and sample in this study were all employees of PT SUA, which was used to obtain research data through the distribution of structured questionnaires. The instrument was tested using validity and reliability tests, and data was analyzed by using spearman rank test. This study suggests that there is a strong effect of perceived usefulness and perceived ease of use on acceptance of IT.
Inovasi Microneedle Patch Pengganti Jarum Suntik Penghantar Vaksin Covid-19 Anak Usia 6-11 Tahun
Authors: Maulida Novi Dwi , Achmad Sri Meidita , Anhar Muhammad Yunanda , Carabelly Amy Nindia 
Published: October 2022

Pendahuluan:
Coronavirus Disease
(Covid-19) merupakan penyakit menular sistem pernapasan yang disebabkan oleh Severe Acute RespiratorySyndrome-Coronavirus 2 (SARS-CoV 2). Virus ini menyerang semua usia termasuk anak-anak. Pemerintah Indonesia menargetkan vaksin Covid-19 untuk 26,5 juta anak usia 6-11 tahun sebagai upaya meningkatkan kekebalan spesifik untuk mencegah Covid-19 dengan menggunakan metodejarum konvensional dan sudah dilakukan di beberapa daerah, tetapi banyak anak yang mengalami ketakutan terhadap jarum suntik. Tujuan:Mengatasi masalah vaksinasi Covid-19 anak yang takut jarum suntik menggunakan metode alternatif microneedle patch. Metode: Penulisan artikel inimenggunakan metode tinjauan pustaka. Tinjauan pustaka yang digunakan berasal dari penelusuran textbooks, jurnal, dan situs web dengan rentangwaktu 2016 hingga 2022. Penelusuran tersebut memperoleh 5 textbooks, 17 jurnal, dan 6 situs web. Kesimpulan: Menuangkan ide dalam berinovasi membuat sediaan dissolving microneedle patch sebagai alternatif penghantar vaksin Covid-19 anak usia 6-11 tahun yang takut jarum suntik untukmempercepat target vaksinasi.
The spirituality in the views of the Soviet and post-Soviet man. Part 1
Authors: Podlesnaia Mariia A. , Ilina Ilona V. 
Published: October 2022

The main objectives of this article are to consider the various meanings of the concept of spirituality, religious (Christian) and non-religious. The authors analysed scientific literature, including such authors, who was directly involved in the study of the spirituality of the Soviet person (L. N. Kogan), and many others who devoted themselves to the study of youth in the USSR, including various aspects of its spirituality (V. T. Lisovskii, S. N. Ikonnikova, V. G. Mordkovich, L. Ya. Rubina, M. Kh. Titma, V. I. Chuprov, V. N. Shubkin). As a result of the analysis, a model was developed that makes it possible to talk about the spirituality of the Christian, Marxist, modern new age movement, with the allocation of basic values, the desired ideal, subjects of the process, etc. Correlation with this model should allow us to solve the main goal of the article – to identify how spirituality (in a religious or non-religious context) is understood by the current generation of student youth, what definitions are given to it, and whether there is continuity in this sense with Soviet ideas about spirituality. The authors came to the following conclusion: the meanings of the spirituality of the Soviet period corresponded to the humanism of the Marxist philosophy of «active man», «creator of culture», transforming not only religious tradition, but also various spheres of private life to suit their ideological needs – family and marriage relations, work, leisure, friendship, set the meaning and purpose of the Soviet man.
Efficacy comparison of Kirschner-wire tension band combined with patellar cerclage and anchor-loop plate in treatment of inferior patellar pole fracture
Authors: Du Bing , Ma Teng , Bai Huanan , Lu Yao , Xu Yibo , Yang Yanling , Zhang Kun , Li Zhong , Li Ming 
Published: October 2022

Objective: This study aimed to compare the biomechanical stability and clinical efficacy of the Kirschner-wire (K-wire) tension band combined with patellar cerclage and an anchor-loop plate (ALP) in treating inferior-pole patellar fracture.Methods: The finite element model was established to analyze the mechanical properties of a K-wire tension band combined with patellar cerclage and ALP fixation in the treatment of inferior patellar pole fracture. The clinical data of 49 patients with patellar inferior-pole fracture (AO/OTA 34 A1) admitted to our hospital from January 2017 to July 2021 were retrospectively analyzed. Among these, 28 cases were fixed with ALPs (ALP group) and 21 cases were fixed with K-wire tension bands combined with patellar cerclage (K-wire group). By reviewing the medical records and follow-up results, we compared the operation time, final knee joint activity, incidence of secondary surgery, postoperative complications, and joint function recovery between the two groups.Results: The biomechanical analysis of the finite element model showed that the maximum displacement of the K-wire group was 1.87 times that of the ALP group. The maximum stress of the K-wire group was 1.34 times that of the ALP group. The maximum stress of the pole bone in the K-wire group was 13.89 times that of the ALP group. The average follow-up times of the K-wire group and ALP group were similar (p &gt; 0.05), and the average ages of the two groups were similar (p &gt; 0.05). The operation time of the ALP group was significantly shorter than that of the K-wire group (p &lt; 0.05).The final knee joint activity of the ALP group was significantly greater than that of the K-wire group (p &lt; 0.05). The Bostman patellar fracture function score of the ALP group was significantly better than that of the K-wire group at 3 and 9 months after operation (p &lt; 0.05). Postoperative complications of the two groups included 1 case (3.6%) in the ALP group with internal fixation-stimulation complications and, in the K-wire group, 3 cases (14.3%) with internal fixation stimulation complications and 1 case (4.8%) with infection.Conclusion: The ALP and K-wire tension band combined with patella cerclage models were tested at 500 N, and no damage occurred, indicating that the newly designed ALP is safe in mechanical structure. The ALP has better therapeutic effect in biomechanical stability, postoperative complications, secondary surgery, and knee function. This technique is an effective method for the treatment of inferior-pole patellar fracture.
Catheter ablation for atrial fibrillation in patients with persistent left superior vena cava: Case series and systematic review
Authors: Gao Mingyang , Bian Yang , Huang Lihong , Zhang Jingrui , Li Changyi , Liu Nian , Liu Xiaoxia , Zuo Song , Guo Xueyuan , Wang Wei , Zhao Xin , Long Deyong , Sang Caihua , Tang Ribo , Li Songnan , Dong Jianzeng , Ma Changsheng 
Published: October 2022

IntroductionPersistent left superior vena cava (PLSVC) is the most common form of thoracic venous abnormality. Catheter ablation (CA) for atrial fibrillation (AF) can be complicated by the existence of PLSVC, which could act as an important arrhythmogenic mechanism in AF.Methods and resultsWe reported a case series of patients with PLSVC who underwent CA for AF at our center between 2018 and 2021. A systematic search was also performed on PubMed, EMBASE, and Web of Science for research reporting CA for AF in patients with PLSVC. Sixteen patients with PLSVC were identified at our center. Ablation targeting PLSVC was performed in 5 patients in the index procedures and in four patients receiving redo procedures. One patient experienced acute procedure failure. After a median follow-up period of 15 months, only 6 (37.5%) patients remained free from AF/atrial tachycardia (AT) after a single procedure. In the systematic review, 11 studies with 167 patients were identified. Based on the included studies, the estimated prevalence of PLSVC in patients undergoing CA for AF was 0.7%. Ablation targeting PLSVC was performed in 121 (74.7%) patients. Major complications in patients with PLSVC receiving AF ablation procedure included four cases of cardiac tamponades (2%), three cases of cardiac effusion (1.5%), one case of ischemic stroke, and three cases of phrenic nerve injury (1.5%) (one left phrenic nerve and two right phrenic nerve). Pooled analysis revealed that after a median follow-up period of 15.6 months (IQR 12.0–74.0 months), the long-term AF/AT-free rate was 70.6% (95% CI 62.8–78.4%, I2 = 0.0%) (Central illustration). Different ablation strategies for PLSVC were summarized and discussed in the systematic review.ConclusionIn patients with PLSVC, recurrence of atrial arrhythmia after CA for AF is relatively common. Ablation aiming for PLSVC isolation is necessitated in most patients. The overall risk of procedural complications was within an acceptable range.
Degos disease with multiple intestinal perforations: A missed-opportunity case report and literature review
Authors: Ai Wen , Liang Zhihua , Li Feng , Yu Haihua 
Published: October 2022

IntroductionDegos disease, also known as malignant atrophic papulosis (MAP), is a rare systemic obstructive vascular disease with unknown pathophysiology, which can affect multiple systems, especially gastrointestinal tract and central nervous system. Intestinal perforations with MAP is associated with high mortality rate and ambiguous treatment outcomes.Case presentationHere we report a missed-opportunity case of Degos disease characterized by generalized skin eruption and multiple intestinal perforations. Definite diagnosis of Degos disease was finally concluded after two exploratory laparotomy operations and skin biopsies. Due to the delayed diagnosis and treatment, the patient died after being discharged automatically in spite of application of aspirin and low-dose subcutaneous heparin. In view of such circumstances, we searched the Pubmed using “Degos [Title] OR Malignant Atrophic Papulosis [Title]” AND “perforation [Title] OR perforations [Title]” and make a detailed analysis of the result.ConclusionsDegos disease is a rare systemic obstructive vascular disease with unknown pathologic mechanism and unavailable treatment methods. Diagnosis is usually based on the presence of pathognomonic skin lesions and tissue biopsy. Gastrointestinal involvement can cause serious and lethal conditions with high mortality. Currently, how to achieve a satisfying prognosis of MAP with intestinal perforations becomes the most urgent problem in front of medical staff.
Lead exposure was associated with liver fibrosis in subjects without known chronic liver disease: An analysis of NHANES 2017–2020
Authors: Zhang Zhiqiang , Li Zhangping , Lin Haiyan , Zeng Zhiyu , Huang Jiaofeng , Li Dongliang 
Published: October 2022

Lead is one of the most important toxic heavy metals in the environment; however, the relationship between blood lead levels and liver fibrosis in individuals without chronic liver diseases (CLD) is unclear. This study used data obtained from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. Multivariate logistic regression was used to explore the relationship between the blood lead level and significant liver fibrosis. A total of 1962 cases without underlying CLD were included, 77 (3.9%) of whom were diagnosed with advanced liver fibrosis by transient elastography. The proportion of advanced fibrosis significantly increased with the blood lead level (p &lt; 0.001), and the blood lead level was higher in the fibrosis group than in the non-fibrosis group (1.2 μg/dl vs 0.9 μg/dl, p &lt; 0.001). After adjusting for relevant confounding factors, the blood lead level was found to be independently associated with advanced liver fibrosis (OR = 1.168; 95% CI, 1.006–1.356; p = 0.041). The blood lead level remained an independent risk factor for advanced liver fibrosis (OR = 1.249; 95% CI, 1.048–1.489; p = 0.013) after controlling for age and sex through propensity score matching. In conclusion, the blood lead level is associated with liver fibrosis in individuals without known CLD.
Comparison of epidural dexmedetomidine to fentanyl in reducing ropivacaine dose in Programmed Intermittent Epidural Bolus plus Patient Controlled Epidural Analgesia during labor: A randomized, double-blind, controlled study
Authors: Pang Ru-Ying , Shen Yao-Hua , Jin Xiao-Qin , Xu Hai-Feng , Wang Yang , Zhu Bin-Xiang , Lin Su-Feng , Xiao Fei 
Published: October 2022

BackgroundDexmedetomidine has been documented to reduce the dose of both intrathecal local anesthetic during cesarean delivery, and the concentration of ropivacaine needed for inducing analgesia during labor. However, few studies have compared adjuvant dexmedetomidine to fentanyl on how they impact the dose of ropivacaine required during labor. The aim of the current study was to evaluate the efficacy of epidural dexmedetomidine at doses of 0.3, 0.4, or 0.5 and 2 μg/ml of fentanyl (the traditional clinical concentration), when added to epidural 0.125% ropivacaine.MethodsThis was a randomized, double-blinded study that comprised one hundred eighty-eight patients, allocated into four groups receiving either epidural fentanyl at 2 μg/ml, or dexmedetomidine at 0.3, 0.4, or 0.5 μg/ml for labor analgesia. The primary outcome was the amount of ropivacaine necessary per hour. Secondary outcomes included visual analogue pain scale (VAS), motor block (Bromage Scale), side effects, patient satisfaction, and neonatal outcomes.ResultsAt the completion of the study, data from 165 participants were analyzed. The mean hourly amount of epidural ropivacaine administered was 16.2 ± 3.3, 14.0 ± 3.1, 13.1 ± 3.7 and 12.1 ± 2.5 ml/h in the 2 μg/ml fentanyl group, and the 0.3, 0.4 and 0.5 μg/ml dexmedetomidine groups, respectively. There was a significant difference among groups in the mean hourly consumption of epidural ropivacaine (P &lt; 0.0001 for 1 way ANOVA). The frequency of PCEA (patient-controlled epidural analgesia) was significantly higher in the fentanyl group than in the three dexmedetomidine groups (P &lt; 0.001), and similar among the dexmedetomidine groups. The mean values of the VAS among all groups were similar over time, P &gt; 0.05. The incidence of pruritus in the fentanyl group was 17.5%, whereas no patient experienced pruritus in any of the dexmedetomidine groups, P &lt; 0.0001.ConclusionThe study demonstrated that epidural dexmedetomidine (0.3 and 0.4 μg/ml) was superior to standard dose epidural fentanyl in reducing the mean hourly amount of ropivacaine administered, and minimizing opioid-related side effects. Further large and multicenter studies would be necessary to confirm the benefits of dexmedetomidine, and potentially serve as an alternative to opioids for routine use in labor analgesia.Clinical trial registration[http://www.chictr.org.cn/showproj.aspx?proj=62846], identifier [ChiCTR2000039067].