bluuebunny/crossref_metadata_2025_split huggingface dataset:
PANC-3 Score in Predicting the Severity of Acute Pancreatitis
Authors: MONICA CHANDRA MOHAN S , SHETTY ABHIJIT S , KUMAR DHANANJAY 
Published: October 2022

Abstract
Background: - Acute pancreatitis is a disease of miscellaneous etiology present as acute abdomen, Inflammatory process of pancreas associated with local and systemic complications. As of now, many scores (such as Ranson’s, APACHE II, Bedside index for severity in acute pancreatitis) that help us in predicting severity at the time of admission. The advantages of the PANC 3 score are to employ widely available tests that are quickly performed and easy to measure. The aim of the present study was to evaluate the efficacy of the PANC 3 score in predicting severity of acute pancreatitis and its relation with the clinical outcome of the disease
Aim and Objective: - PANC-3 score in predicting the severity of acute pancreatitis.
Materials and Methods: -The PANC 3 score was determined by measuring three variables obtained within the first 24 h after diagnosis of acute pancreatitis: 1) Haematocrit; 2) body mass index (BMI); and 3) pleural effusion on the chest X-ray. It is a prospective study in which 60 patients were evaluated with PANC3 Scoring, who were diagnosed with acute pancreatitis and admitted to DEPT OF GENERAL SURGERY, K.S. HEGDE MEDICAL ACADEMY, MANGALORE
Result: - The results showed that PANC3 score had a sensitivity of 80%, and the specificity was 95.5%. The PPV was 85.7%, and the NPV was 93.5%, the diagnostic accuracy is 91% in predicting severe acute pancreatitis.
Conclusion: -PANC3 SCORE is a useful tool to approach and predict the severity of acute pancreatitis, due to its high efficacy, easy application and rapid results, which enables classification of cases and early treatment
The Prevalence of Depressive Symptoms Among Fibromyalgia Patients
Authors: Allahham Amr , Bakkar Batoul , Kikhia Judy , Khalayli Karam , Kudsi Maysoun 
Published: October 2022

Abstract
Background
Fibromyalgia is a noninflammatory musculoskeletal pain disorder which predominantly affects women and is often associated with depression.
Purpose
The main aim of this study was to reveal the depressive symptoms in participants who suffered from fibromyalgia.
Methods
A web-based cross-sectional survey was performed. Five hundred twenty-five women and men with a mean age of 27.12 ± 7.87 years old were recruited. The patients were divided into the case (patients with fibromyalgia) and control (healthy patients). The BDI scores and depression ranges were collected.
Results
8% of participants were found to meet the modified ACR 2010 criteria for FM diagnosis, of whom 85.7% were females. The prevalence of depressive symptoms among participants with fibromyalgia was 90.5%
Conclusion
Patients with FMS had higher BDI scores than healthy controls.
FSCLBF: Feature Selection based on Correlation Label and B-R Belief Function in Multi-label Data
Authors: Mehravaran Zahra , Hamidzadeh Javad , Monsefi Reza 
Published: October 2022

Abstract
In many real-world problems, each sample has over one label, which may also have semantic correlations between labels. However, in multi-label datasets, there are many irrelevant features that impact the accuracy of multi-label learning. Using feature selection to improve accuracy is an effective method. Even though numerous papers have presented novel methods to feature selection, more effort has to be done to improve the accuracy of such methods. This paper presents a novel feature selection method based on correlation labels using a belief function called FSCLBF. Our proposed method increases the accuracy of multi-label learning by considering the correlation labels and the data uncertainty. The proposed method's first step is to select the essential features for each label using a belief function based on a rough set theory (B-R belief function). Then, we identify the equivalent labels according to the overlapping based on their essential features. In the next step, the tag of samples is determined in the set of equivalent labels. Finally, we select the essential features for each equivalent label set, using the B-R belief function by considering the sample differentiation to label. The experimental results show the superiority of FSCLBF to state-of-the-art methods in terms of Hamming loss, One-error, and Accuracy measures.
Dynamic analysis as a method of wells interaction evaluation in making technological decisions
Authors: Abbasova Samira , Mamedova Gulbahar 
Published: October 2022

The complexity of developing oil fields determines the creation and improvement of fundamentally new approaches to the analysis and management of various technological processes of oil production based on indirect methods of interpreting current geological and field information for making strategic and tactical decisions to rationalize it.This article discusses the formation of stagnant and poorly drained zones of oil deposits due to the redistribution of hydrodynamic flows of reservoir fluids.
In order to analyze and evaluate the effectiveness of applying the technology to change the direction of filtration flows in the reservoir under consideration, it is necessary to study the influence of non-stationary processes on oil production.
Based on the construction of operational maps of total oil and water production, water cut and the degree of interaction by periods of development, the state of the reservoir system is analyzed and conclusions are made about the characteristic features of the direction of water-oil flows with the subsequent formation of stagnant zones.
The proposed approach to decision-making allows to carry out the dynamic regulation of hydrodynamic flows in order to stabilize and reduce oil production losses for the period under consideration and make the necessary decision on the issuance of technological recommendations for the impact on the operation of the exploitation object, taking into account the minimization of energy and resource costs.
The proposed method was tested on the example of the analysis of the state of development of one of the fields in Azerbaijan, which is in the final stage of development. As an information array, the dynamics of changes in oil and water flow rates by wells in various periods of development was chosen.
Analysis of the main design and operating parameters of the device for the fermentation of bird droppings
Authors: Hajiyev Rovshan , Saidov Rasim , Mammadov Gabil , Taghiyev Urfan , Allahverdiyeva Gahira 
Published: October 2022

The study on the utilization of poultry droppings put forward the need for the constructive and technological improvement of the biofermentation device. A drum-type bioreactor better meets the requirements for the technological process of eco-friendly biologically active fertilizer production from livestock and poultry wastes. However, the great size of the heat transfer surface of the bioreactor drum and its significant ejection momentum during spinning require quite a lot of energy. To decrease this consumption, the main constructive parameters should be optimized. The main reason is the sharp increase in prices for mineral fertilizers, the weak economic condition of most farms, the lack of advanced processing technologies and the use of organic fertilizers.
Our aim in these studies was to analyze the types of design and operating parameters of the device for the fermentation of bird droppings. To this end, we conducted a study on the disposal of bird droppings, and also put forward the need for constructive and technological improvement of the biofermentation device. One of such ways to solve the problem was a drum-type bioreactor, which, according to our research indicators, better meets the requirements for the technological process of producing environmentally friendly biologically active fertilizers from animal husbandry and poultry waste, however, the size of this equipment of the heat transfer surface of the bioreactor drum and its significant emission pulse during rotation require a rather large waste of energy. To reduce this consumption, it is necessary to optimize the basic design parameters.
Devices that work continuously were recognized as the most promising. They fully meet the technological and operational requirements
Study of the laser radiation effect in combination with doxorubicin on the survival of MCF7 and MCF7DOX culture cells
Authors: Konovalenko Sergii , Lykhova Oleksanra , Chepurna Oksana , Prokopenko Igor , Naleskina Lesia , Chekhun Vasyl 
Published: October 2022

The use of lasers in oncology is constantly evolving. In recent years, the mechanisms of the effect of laser radiation, particularly of the infrared spectrum, on tumour cells in combination with various chemotherapeutic agents have been studied.
The aim. To study the effect of laser radiation with a wavelength of 660 and 810 nm on the survival of tumour cell cultures MCF7 and MCF7DOX in the presence of doxorubicin.
Materials and methods. Tumour cells of MCF7 and MCF7DOX cultures were cultured in DMEM medium (Biowest, France) with 10 % fetal calf serum (FST) (Biowest, France) and 40 μg / ml gentamicin (Sigma, USA). Doxorubicin was added to the cells to a final concentration of 1 μg / ml. Cells were irradiated with a laser (Photonica-Plus, Ukraine) with a wavelength of 660 and 810 nm (irradiation time – 5 min, power density – 50 mV/cm2, irradiation dose 15 J/cm2). The results were recorded using a multiwell spectrophotometer (Labsystems Multiskan PLUS, Finland). Photomicrographs of cells were taken using a Carl Zeiss microscope, Germany.
Results. Cell survival assessment and morphological characteristics in micropreparations indicate the antitumor efficacy of the combined effects of laser irradiation and doxorubicin. The most pronounced cytotoxic effect on MCF7-DOX culture cells was caused by doxorubicin exposure for 90 min in combination with infrared laser irradiation (λ=810 nm).
Conclusions. Infrared laser light synergises with the toxic effects of doxorubicin and creates favourable conditions for apoptosis of tumour cells, as evidenced by cytomorphological data.
Determination of technological parameters of obtaining stevia extract
Authors: Belemets Tatiana , Kuzmyk Uliana , Gryshchenko Roman , Osmak Tetiana 
Published: October 2022

The prospects for the use of a plant raw material – stevia as a natural sweetener for obtaining sweet extracts have been substantiated. Literary research has been conducted on the expediency of carrying out preparatory operations of stevia-raw material in order to intensify mass exchange processes during extraction; their necessity has been theoretically justified.
A number of studies have been conducted with the aim of intensifying the process of extracting the dry mass of stevia leaves. Preliminary preparation of stevia was carried out – crushing (using a laboratory crusher – A1-DM2R) and subsequent sieving to the average size of the leaf fraction – 3.9±0.1 mm.
It is proposed to use whey from the production of sour milk cheese to obtain sweet extracts of stevia for their further use in the food industry.
It has been established, that the highest efficiency of the extraction process of the prepared dry stevia leaf mass is achieved with a hydromodule – 1:15. Carrying out the process under these conditions allows to achieve the highest degree of extraction of extractive substances – 29.9.
The results of the experimental studies, obtained and presented in the article, can be used to carry out further physicochemical analyzes of the quality of the obtained stevia extracts and the possibility of combining them with a milk base to obtain a dietary range of food products
Temperature effect on the structural features of j.3-glycosidase from sulfolobus solfataricus. an infrared study
Authors: D'Auria Sabato , Rossi Mose , Nucci Roberto , Bertoli Enrico , Tanfani Fabio 
Published: October 2022

Abstract:
In this paper we report the temperature effect on the structural properties of a thermostable 13-
glycosidase isolated from archaeon Sulfolobus solfataricus monitored by infrared spectroscopy. The
investigations were carried out at pH 10, because at neutral pH's values the llenaturation process did
not take place. The denaturation process was irreversible and sodium dodecyl sulfate additions to the
enzyme solution caused a lower temperature and a lower onset of the protein denaturation.
Striking structural resemblance between small cysteine-rich proteins with diverse functions
Authors: Geerestein-Ujah E.C. Van , Breg J.N. , Sarda L. , Cozzone P.J. , Kaptein R. 
Published: October 2022

Abstract:
We have established a striking structural resemblance between the two domains of procolipase and several other small cysteine-rich proteins of diverse functions. The proteins share a common scaffold although the sequence homology, apart from the cysteine pattern is quite low. The descriptions we delineate here should provide further constraints for use in the design of stable functional small proteins for pharmaceutical and chemical applications.
Preliminary x-ray crystallographic analysis and molecular replacement studies with 2,5-diketo-d­ gluconate reductase
Authors: Blaber Michael , Khorana Sumit , Powerst Davd B. , Andersont Stephen 
Published: October 2022

Abstract:
2,5 diketo-D-gluconate reductase (2,5-DKG reductase) is an enzyme with considerable commercial interest because it can be used to manufacture 2-keto-L-gulonic acid, a key intermediate in the industrial synthesis of L­
ascorbic acid. This protein was crystallized in the monoclinic space group P21 with one molecule in the asymmetric unit. The crystals diffract to a maximum resolution of 1.9 A. An x-ray intensity data set was collected from these crystals and is 85% complete between 60 to 2.1 A. An initial structure solution has been attempted using the molecular replacement method with human aldose reductase (38% sequence identity) as a search model. The rotation and translation function searches yield a single clear peak above the background
noise level with a corresponding R factor of49.2% and a correlation coefficient of34.0%.
Interaction of a partial calmodulin-binding domain of caldesmon with calmodulin
Authors: Zhang Mingjie , Voge Hans J. 
Published: October 2022

Abstract:
Caldesmon (CaD) is associated with the thin filaments of smooth muscle tissues. Limited proteolysis studies of CaD reveal that the sequence w659 EKGNVF is involved in binding the calcium-regulatory protein calmodulin (CaM). Using transferred nuclear Overhauser enhancement NMR measurements, we have found that the 8 and 11
residue synthetic peptides KS(MWEKGNVF)S bind with an a-helical structure to CaM. Proton NMR titration studies show that a 2:1 peptide to CaM complex is formed, suggesting that the two domains of the dumbbell-shaped CaM can bind one equivalent of peptide each with similar binding constant.
Introduction of trypsin specificity into chymotrypsin inhibitor ii
Authors: Leatherbarrow Robin J. , Hasan Zulfiqar 
Published: October 2022

Abstract:
A unique cysteine residue was introduced into the P1 pos1t1on of chymotrypsin inhibitor II (CI2) by
- Jigonucleotide-directed mutagenesis (Met59 Cys). Chemical modification of CI2M59C with 2- bromoethylamine, 3-bromopropylamine and 2-mercaptoethylamine resulted in the introduction of lysine-sulfur analogues at the P1 position. Unlike the original CI2, all three modified inhibitors exhibited moderate but effective inhibition of trypsin. The results demonstrate that genetic and chemical modification can be successfully combined to tailor inhibitory specificity.
Long-term Follow-up of Patients With Hernia Using the Hernia-Specific Quality-of-Life Mobile App: Feasibility Questionnaire Study
Authors: Huang Ching-Shui , Tai Feng-Chuan , Lien Heng-Hui , Wong Jia-Uei , Huang Chi-Cheng 
Published: October 2022

Background
Hernia repair is one of the most common surgical procedures; however, the long-term outcomes are seldom reported due to incomplete follow-up.

Objective
The aim of this study was to examine the use of a mobile app for the long-term follow-up of hernia recurrence, complication, and quality-of-life perception.

Methods
A cloud-based corroborative system drove a mobile app with the HERQL (Hernia-Specific Quality-of-Life) questionnaire built in. Patients who underwent hernia repair were identified from medical records, and an invitation to participate in this study was sent through the post.

Results
The response rate was 11.89% (311/2615) during the 1-year study period, whereas the recurrence rate was 1.0% (3/311). Causal relationships between symptomatic and functional domains of the HERQL questionnaire were indicated by satisfactory model fit indices and significant regression coefficients derived from structural equational modeling. Regarding patients’ last hernia surgeries, 88.7% (276/311) of the patients reported them to be satisfactory or very satisfactory, 68.5% (213/311) of patients reported no discomfort, and 61.1% (190/311) of patients never experienced mesh foreign body sensation. Subgroup analysis for the most commonly used mesh repairs found that mesh plug repair inevitably resulted in worse symptoms and quality-of-life perception from the group with groin hernias.

Conclusions
The mobile app has the potential to enhance the quality of care for patients with hernia and facilitate outcomes research with more complete follow-up.
Comparison of Medical Students Consideration for Choosing a Specialty in 2010 and 2020
Authors: Schroeder Hanna S. , Shacham Alon , Amar Shimon , Weissman Charles , Schroeder Josh E. 
Published: October 2022

Introduction: Understanding ” what is most important” to
medical-students can help improve residence learning and working
conditions. Such information is needed to facilitate policy planning
that will encourage the next generation of physicians to specialize in
medical-fields that are experiencing shortages. The hypothesis was,
there are significant changes in medical students’ preferences,
regarding the considerations for choosing a medical specialty in 2020 as
compared to students a decade earlier. Methods: A time comparison
cross-sectional study of 5 -year medical students
from two universities took place in 2010 and 2020. A questionnaire was
used to examine various aspects of the specialty selection process.
Results: 335 medical-students answered the survey (237
and 98 in 2010 and 2020, respectively). Medical students in 2020 in
comparison to 2010, were 2.26 time less likely to choose a residency
because of its potential for a high income (P<0.05), had
significantly more interest in residencies with greater teaching (98.8%
vs 82.9%, P<0.05) and increased responsibility/chance to
make clinical decisions on their own (67.9% vs 51.6%,
P<0.05). There were criteria which were important to both the
2010 and 2020 students, such as, choosing a bedside specialty (70.2%vs
67.9%, NS), an interesting and challenging residency (95.2%v s 91.3%,
NS) and interest in a specialty that involved working in the operating
room (29.8% vs 32.6%, NS). Conclusions: These results reinforce
the idea of avoiding stereotypes based on the generational cohort and
the importance of exploring the needs and motivations of medical
students. Notably, we found that the 2020 medical-students were more
interested than their predecessors in residencies with much resident
teaching and more responsibility/making clinical decisions on their own.
In addition, we found that selection criteria such as, importance of
choosing a specialty that one finds interesting and challenging, are
universal over time.
Epidemiological characteristics of papillomavirus infection of anogenital localization in Tatarstan republic
Authors: Agliullina S. T. , Eremeeva Zh. G. , Minullin I. K. , Naumova A. Ya. , Sabaeva F. N. , Fazulzyanova I. M. 
Published: October 2022

Due to the high prevalence of anogenital warts, their significant economic and psychosocial burden, the lack of routine vaccination against papillomavirus infection, monitoring of the epidemiological situation for one of the common forms of papillomavirus infection – anogenital warts is relevant.The aim is to assess the epidemiological situation of anogenital warts in Tatarstan Republic for 2011–2020.Materials and methods. The study design is an observational descriptive epidemiological study. A retrospective epidemiological analysis of the incidence of anogenital warts in Tatarstan Republic for 2011–2020 was carried out. The analysis of long-term dynamics of incidence of the population as a whole and in age and sex groups is carried out. The structure of the incidence of anogenital warts was assessed. Intensive (per 100,000) and extensive morbidity rates (%) were calculated.Results. There is a decrease in the incidence of anogenital warts in Republic Tatarstan from 123,80/0000 in 2011 to 68,80/0000 in 2020. The dynamics of the incidence of anogenital warts among the female and male population had a unidirectional character – a decrease in the incidence. A comparison of incidence levels showed that the incidence of women was higher than that of men (80,40/0000 versus 55,80/0000, respectively, in 2020). The greatest incidence of anogenital warts was observed in the 18–29 age group during the observation period. The average annual incidence of anogenital warts in women aged 18–29 was 535,60/0000, in men of the same age group – 233,00/0000.Conclusion. Despite the decrease in the incidence of anogenital warts in Tatarstan Republic as a whole and in certain age and gender groups, high levels of incidence among people aged 18-29 years remain. The data obtained from the results of a retrospective analysis of the incidence of anogenital warts indicate the need to introduce routine vaccination against HPV infection, which will prevent large treatment costs, and will have a positive impact on public health indicators.