bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote monitoring of gestational diabetes with my Sugr App integrated to diabetology EMR during Covid-19 emergency
Authors: Lacaria, E.  
Published: November 2022

The aim of our study was demonstrate how the implementation of a shared management process using innovative tools, such as telemonitoring with a mobile app, has a benefits in term of facilitating the management of women with GD and reducing access to hospitals. Due to COVID-19 emergency in 2020, the integration between the Diabetologist EMR (SDC) and mySugr app for people with diabetes was activated for 4 months; the patient can enter blood sugar and other clinical data in the app for recording and tracking data directly in the EMR. The telemonitoring service was proposed to pregnant patients to avoid further direct access for the visits. The analysis of glycemic control and maternal-fetal outcome was performed on a total of 46 pregnant women (38 Italian and 8 foreign, age 35.4 ± 4.9 years, graduates 73%, pre-pregnancy BMI 24.9 ± 5.4 Kg / m2) enrolled on average at 30 ± 5 weeks. The total blood glucose levels recorded were 8818 (176 ± 98 blood sugar levels per patient), the mean pre- and post-meal blood glucose levels were respectively 96 ± 9.8 mg / dl and 127.8 ± 34.6 mg / dl. Delivery took place at 39 ± 2 weeks, in 65.2% spontaneously (34.8% Caesarean section) in the absence of preterm births or birth trauma. All the women examined showed a high degree of satisfaction. Despite numerical limitation, this experience shows how the use of my- Sugr app integrated with SDC can offer to Diabetologists a secure data flow in electronic format, permitting an immediate consultation and a subsequent benefits on the metabolic control in women with GD. The solutions used are appreciated by all pregnant women and allowed the reduction of access to diabetes Centers. The implementation of this experience of telemedicine management is also desirable outside the period of COVID-19 emergency. KEY WORDS diabetes; telemedicine; pregnancy.
Application of data analysis and game theory to competitive Pokémon battle sets
Authors: Bhagwat Dhruva 
Published: November 2022

<p>This paper analyzes a scenario where two hypothetical Pokémon trainers each have 3 Pokémon and each send out 1 to battle. We form an experiment through repeated battles between each Pokémon matchup to create payoff values for each Pokémon. Game theory and the process of finding a Nash equilibrium are applied to this scenario to determine both the best outcome for both trainers, and how the results state which trainer has more powerful Pokémon sets. Iterated dominance, best responses, and mixed strategies are used routinely to solve for the Nash equilibrium solution. The application of game theory, Nash equilibrium, and data analysis to economics is briefly discussed. </p>
Reibwertermittlung für die Alu-Warmblechumformung/Measuring friction for aluminum hot forming
Authors: Filzek Jan , Schell Lukas , Groche Peter 
Published: November 2022

Tribometer für die Reibwertermittlung konventioneller Blechumformprozesse wurden bereits im 20. Jahrhundert zu hohem Reifegrad entwickelt. Insbesondere der Streifenziehversuch hat sich in der Branche als Standardprüfmethode etabliert. Neue Herausforderungen ergeben sich durch moderne Aluminium-Warmumformprozesse: Was ist bei der Reibwertermittlung für diese Prozesse zu beachten und wo stößt physikalische Modellbildung an Grenzen?

Sophisticated tribometers for determining the friction coefficient of conventional sheet metal forming processes had already been developed in the 20th century. The strip drawing test, in particular, was established as a standard test method for sheet metal forming. New challenges arise from modern aluminum hot forming processes: What needs to be considered when determining the friction coefficient for these processes and where are the limits of physical based modelling?
Modellierung rührreibgeschweißter Blechverbunde/Modelling of friction stir welded tailored blanks
Authors: Bachmann Maximilian , Riedmüller Kim Rouven , Liewald Mathias , Suske Vincent , Ilg Christian 
Published: November 2022

In der blechverarbeitenden Industrie nehmen Bedeutung und Einsatz von belastungsgerechten Leichtbaustrukturen mit einem geringen CO2-Fußabdruck stetig zu. Diesbezüglich ermöglicht die Technologie des Rührreibschweißens, Blechverbunde aus Aluminium- und Stahllegierungen in unterschiedlichen Dicken zu fügen. Mit Blick auf eine möglichst intelligente Auslegung des Umformprozesses solcher Blechverbunde wird in diesem Beitrag ein Modellierungsansatz für einen Hybridblechverbund aus DX54 und AL6016 mit besonderer Berücksichtigung der Schweißnaht vorgestellt.

In the sheet metal processing industry, relevance and application of load-oriented lightweight structures requiring a low carbon footprint are steadily increasing. In this respect, friction stir welding allows joining of tailor welded blanks made of aluminum and steel sheets of different thicknesses. Focusing on an intelligent engineering of the forming process of such tailor welded blanks, this paper presents a modelling approach for a hybrid sheet metal compound made of DX54 and AL6016 with particular consideration of the weld seam.
Digitalisierung im Unternehmen – Industrie 4.0/Digitalization and Industry 4.0 in companies
Authors: Stricker Nicole , Rupp Andreas , Hofmann Sara , Meyer Julian 
Published: November 2022

Digitalisierung und Industrie 4.0 sind spätestens seit 2011 ausgerufen und werden in den Unternehmen umgesetzt. Die Einführung erfordert eine intensive Auseinandersetzung mit der Thematik. Erste Erfolge sind oft in Form von einzelnen Pilotprojekten schnell umgesetzt. Das flächendeckende Ausrollen ist jedoch oft deutlich schwerer zu realisieren. Dieser Beitrag möchte ein Blitzlicht auf die aktuelle Umsetzung werfen, 11 Jahre nach dem Ausrufen von Industrie 4.0.

Digitalization and Industry 4.0 have been proclaimed since 2011 at the latest and are being implemented in companies. The introduction requires an intensive examination of the topic. Initial successes are often quickly implemented in the form of individual pilot projects. However, it is often much more difficult to roll out. The article would like to throw a spotlight on the current implementation, 11 years after the proclamation of Industry 4.0.
Assessment of the liver microcirculation by laserdoppler flowmetry after extended liver resection in the experiment
Authors: Leonov S. D. , Khalepo O. V. , Rodin A. V. , Karasev A. S. , Sorokina A. A. , Panchenkov D. N. 
Published: November 2022

Purpose. To assess microcirculation and mechanisms of its regulation in the liver after its extended resection.Materials and methods. 10 Wistar rats of both sexes weighing 180–270 g which had median laparotomy under general anesthesia were taken in the trial. Microcirculation in the liver of rats was assessed with LAKK-02 Laser-Doppler flowmeter (Russia). A light guide for determining microcirculation was placed on the visceral surface of the right liver lobe; parameters of Laser-Doppler flowmetry (LDF-gram) were registered for 7 min. Then, ligatures were sequentially applied to the left lateral and median lobes of the liver followed by their cutting off; then, about 70 % of the organ were removed. After removal of both liver lobes, LDF-gram was recorded again for 7 minutes with a sensor placed on the visceral surface of the right liver lobe. Basic microcirculation parameters were registered before and after extended liver resection.Results. After the extended liver resection, average arithmetic parameters of microcirculation in the liver parenchyma decreased by 11.71 % (p < 0.05), which indicates the decrease in the microvasculature perfusion. At the same time, indicators of standard deviation of the microcirculation index and the coefficient of variation did not change statistically significantly. The median maximum amplitude of neurogenic oscillations after the resection increased by 2.3 points (p < 0.05). The amplitude of myogenic oscillations also increased after resection (p < 0.05); however, the degree of increase was less than that of the neurogenic rhythms. It was found that in 70 % of animals the maximum amplitude of endothelial oscillations increased in the liver microcirculation after the extended resection; however, in general, differences between the average endothelial oscillations before and after the resection were not statistically significant.Conclusion. In the experimental liver resection, the most informative and reliable LDF criteria on ischemia development in the liver stump were average arithmetic microcirculation indices as well as the amplitude of neurogenic and myogenic oscillations. The authors emphasize that the degree of changes in these indices may be a sign of ischemia severity in the liver stump after its resection and may have a prognostic value, although the results obtained require further research.
GOALS-JWST: Resolving the Circumnuclear Gas Dynamics in NGC 7469 in the Mid-infrared
Authors: U Vivian , Lai Thomas , Bianchin Marina , Remigio Raymond P. , Armus Lee , Larson Kirsten L. , Díaz-Santos Tanio , Evans Aaron , Stierwalt Sabrina , Law David R. , Malkan Matthew A. , Linden Sean , Song Yiqing , van der Werf Paul P. , Gao Tianmu , Privon George C. , Medling Anne M. , Barcos-Muñoz Loreto , Hayward Christopher C. , Inami Hanae , Rich Jeff , Aalto Susanne , Appleton Philip , Bohn Thomas , Böker Torsten , Brown Michael J. I. , Charmandaris Vassilis , Finnerty Luke , Howell Justin , Iwasawa Kazushi , Kemper Francisca , Marshall Jason , Mazzarella Joseph M. , McKinney Jed , Muller-Sanchez Francisco , Murphy Eric J. , Sanders David , Surace Jason 
Published: November 2022

Abstract
The nearby, luminous infrared galaxy NGC 7469 hosts a Seyfert nucleus with a circumnuclear star-forming ring and is thus the ideal local laboratory for investigating the starburst–AGN (active galactic nucleus) connection in detail. We present integral-field observations of the central 1.3 kpc region in NGC 7469 obtained with the JWST Mid-InfraRed Instrument. Molecular and ionized gas distributions and kinematics at a resolution of ∼100 pc over the 4.9–7.6 μm region are examined to study the gas dynamics influenced by the central AGN. The low-ionization [Fe ii] λ5.34 μm and [Ar ii] λ6.99 μm lines are bright on the nucleus and in the starburst ring, as opposed to H2 S(5) λ6.91 μm, which is strongly peaked at the center and surrounding ISM. The high-ionization [Mg v] line is resolved and shows a broad, blueshifted component associated with the outflow. It has a nearly face-on geometry that is strongly peaked on the nucleus, where it reaches a maximum velocity of −650 km s−1, and extends about 400 pc to the east. Regions of enhanced velocity dispersion in H2 and [Fe ii] ∼ 180 pc from the AGN that also show high L(H2)/L(PAH) and L([Fe ii])/L(Pfα) ratios to the W and N of the nucleus pinpoint regions where the ionized outflow is depositing energy, via shocks, into the dense interstellar medium between the nucleus and the starburst ring. These resolved mid-infrared observations of the nuclear gas dynamics demonstrate the power of JWST and its high-sensitivity integral-field spectroscopic capability to resolve feedback processes around supermassive black holes in the dusty cores of nearby luminous infrared galaxies.
The Maximum Isotropic Equivalent Energy of Gamma-Ray Bursts
Authors: Dado Shlomo , Dar Arnon 
Published: November 2022

Abstract
In the cannonball model of gamma-ray bursts (GRBs), a highly relativistic jet of plasmoids of ordinary stellar matter that is ejected during stellar collapse or shortly after by fallback matter, produces simultaneously a GRB and a cosmic-ray burst by scattering light and charged particles in its path. This association and the observed knee at ∼1 TeV in the energy spectrum of Galactic cosmic-ray electrons imply a maximum peak energy ∼2.25 MeV in the energy spectrum of GRBs in the 1 keV–10 MeV band. Such a peak energy and the Amati correlation in GRBs imply a maximum isotropic equivalent energy release of ∼3.8 × 1054 erg in GRBs, in the 1 keV–10 MeV band. Both predictions are in good agreement with up-to-date observations.
The Dark Matter Tidal Stripping History of the Sagittarius Core with N-body Simulations
Authors: Wang Hai-Feng , Hammer Francois , Yang Yan-Bin , Wang Jian-Ling 
Published: November 2022

Abstract
The infall of the Sagittarius (Sgr) dwarf spheroidal galaxy in the Milky Way halo is an unique opportunity to understand how the different components of a dwarf galaxy could be tidally removed. In this work, we reconstruct the Sgr core morphology and kinematics on the basis of a model that has already successfully reproduced the Sgr stream. Here we use a very high resolution model that almost resolves individual stars in the Sgr core. It reproduces most of the observed morphology and kinematic properties, without specific fine tuning. We also show that the dark matter may have been almost entirely stripped by Milky Way tides after two passages at the pericenter. Finally the model predicts that the Sgr core will be fully disrupted within the next 2 Gyr.
Comparison of Dental Occlusion in Children with Mouth Breathing and Different Types of Pharyngeal Lymphoid Tissue Obstruction
Authors: Ahmed Tanzeem , Ahmed Samsuddin , Kaushal Nikhil 
Published: November 2022

Background:
The relationship between malocclusion and respiration has been debated for decades.

Aim:
The aim of this study is to assess dental occlusion in relation to mouth breathing and different types of pharyngeal lymphoid tissue obstruction in children.

Settings and Design:
This was a cross-sectional study of 200 children aged between 6 and 12 years who were clinically examined and divided into two groups: mouth breathers and nasal breathers.

Materials and Methods:
The children were subjected to otorhinolaryngologic examination to identify the type of pharyngeal obstruction. Dental interarch relationship and pharyngeal tissue obstruction were diagnosed and appropriate cross tabulations were done.

Statistical Analysis Used:
The data collected were statistically analyzed using the SPSS version 15.0 software.

Results:
Statistically significant association was found between type of breathing and pharyngeal lymphoid tissue obstruction (P = 0.001), dental occlusion and type of breathing (P = 0.001), and pharyngeal lymphoid tissue obstruction and dental occlusion (P = 0.001). Higher prevalence of crossbite, deep bite, and Class II malocclusion was seen in children with adenotonsillar hypertrophy as well as mouth breathing habit.

Conclusion:
Obstructive tonsils and adenoids are risk factors for the development of malocclusion. Early detection and correction of airway obstruction can help in proper growth of the dentofacial region.
How Much Disinfected Ground Tooth Do We Need to Fill an Empty Alveolus after Extraction? Experimental in vitro Study
Authors: Calvo-Guirado José Luis , De Carlos-Villafranca Felix , Garcés-Villalá Miguel Angel , García-Carrillo Nuria , Jindal Vidushi , Martinez-Martínez Francisco 
Published: November 2022

Aim and Objectives:
The main objective of this study was to evaluate how much crushed, extracted human teeth material can use to fill an empty alveolus of the mandibular anterior teeth.

Material and Methods:
Fifty-four human teeth were collected from 10 donors due to advanced periodontal disease. The patients were clinically selected, signed informed consent, and receive no financial compensation for participating in this study. Fifty-four teeth were mechanically cleaned, dried, sectioned, and grounded. All teeth are grounded using the Smart Dentin Grinder machine. Cone-beam computed tomography scanners of each patient were done and processed the standard tessellation language images by a three-dimensional (3D) printer, and 3D models were obtained.

Results:
The mean of each alveolus was 12.1 ± 0.34 mm for lower incisors and 17 ± 0.29 mm for lower canines. The mean values of root material we need for central and lateral incisors alveolus filling were 0.298 ± 0.14 cc, and for lower canines was 1.02 cc. Therefore, we need one root or one and half-crowns must be needed to fill a lower incisor alveolus. A lower canine needs at least one canine root or one canine crown and two lower incisors crown to fill the canine alveoli.

Conclusions:
Dentin is a helpful graft to fulfill an empty alveolus due to osteoinductive properties, and a ground crown is useful for buccal bone protection due to osteoconductive properties before and after implant placement.
Preliminary Report on Histopathology of Odontogenic Keratocyst in Third Dimension: Three-Dimensional Video and Images
Authors: Tamgadge Sandhya , Tamgadge Avinash 
Published: November 2022

Introduction:
Odontogenic keratocyst (OKC) is a developmental odontogenic cyst of the jaws that causes extensive destruction even before the clinical manifestations are evident. It is a well-known entity among private practitioners as it has a high recurrence rate and requires meticulous treatment planning. Unfortunately, clinicians have less understood its basic histopathology.

Objective:
This article highlights the preliminary attempt of an author in designing third dimension of histopathological aspect of OKC so that it is easily understood by oral pathologists, general pathologists, nonpathologists, students, and even patients too.

Methodology:
Preliminary three-dimensional (3D) images and videos on histopathological aspect of OKC were designed by the author using 3DMax (Autodesk Media and Entertainment) and Adobe Premiere Pro 5.5 software which is a video editing software (Adobe Systems) based on two-dimensional descriptions mentioned in the literature.

Results:
Internal cellular architecture of OKC was created in a lifelike manner through 3D animation video and images.

Conclusion:
Histopathological aspect of all oral lesions should be explained in third dimension too.
Immunohistochemical Evaluation of p16 and p53 in Oral and Oropharyngeal Squamous Cell Carcinoma with Special Regard to Human Papillomavirus Status
Authors: Ghosh Urvashi , Tripathy Rajashree , Lenka Anasuya , Turuk Jyotirmayee , Mohapatra Debahuti 
Published: November 2022

Abstract

Background:
Incidence of human papillomavirus (HPV)-associated oral and oropharyngeal squamous cell carcinomas (OSCC and OPSCC) is on a rising trend globally and has specific therapeutic implications. HPV-related tumors have a distinct pathogenetic mechanism targeting p16 and p53 both. However, there are limited studies evaluating p16 and p53 expression in combination.

Aim:
The aim of the study is to evaluate p16 and p53 immunohistochemical expression pattern in OSCC and OPSCC, with special reference to HPV association.

Study Design:
This was a hospital-based prospective study done over 22 months (September 2018 to June 2020), including a total of 54 cases of OSCC and OPSCC. They were subjected to clinicopathological evaluation, p16 and p53 immunohistochemistry, and DNA polymerase chain reaction testing for testing of HPV association, followed by analysis of data by statistical methods.

Results:
Out of 54, 43 cases were OSCC and 11 cases were OPSCC. A total of nine cases were HPV positive. HPV association was found to be significant with tonsil as primary site, age range between 40 and 60 years, and absence of tobacco or alcohol habit. Presence of HPV infection was also significantly associated with p16 overexpression, in combination with p53 negativity. The findings indicate that p16 overexpression combined with a negative p53 expression can be used for HPV detection and the former alone may be used as diagnostic marker in OPSCC only.

Conclusion:
HPV-associated OSCC and OPSCC are a unique subset of cancers, and using combination of molecular biomarkers could help in diagnosis and prognosis.
Seizures in children
Authors: Dzefi-Tettey Klenam , Edzie Emmanuel Kobina Mesi , Brakohiapa Edmund Kwakye , Kekessie Kafui Kossi , Piersson Albert Dayor , Acheampong Franklin , Gorleku Philip Narteh , Nixon Harold Ricketts , Asemah Abdul Raman , Kusodzi Henry 
Published: November 2022

Background:
The current imaging modality of choice in the evaluation of patients with seizures is magnetic resonance imaging (MRI). MRI with a specific seizure protocol considerably has a positive impact on patients' management. This study determined the spectrum of brain findings in children with seizures.

Materials and Methods:
The study subjects were 191 children aged 1–16 years who presented with seizures within January 2017–August 2021. Socio-demographics and MRI examinations were retrospectively studied. Brain MRI images of patients with their respective reports were analyzed by experienced radiologists. Data from these reports were collected and coded into Statistical Package for Social Sciences (SPSS) version-20.0 for analysis.

Results:
One hundred and ninety-one children were included in the study comprising 99 (51.8%) males and 92 (48.2%) females. Abnormal brain images were noted in 89 (46.6%) of the study population. The most common abnormalities were cerebral atrophy 41 (21.5%), white matter T2 Fluid-attenuated inversion recovery hyperintensities 22 (11.5%), and temporal lobe atrophy 9 (4.7%). Twenty-six (29.2%) of the children presented with multiple lesions and these were more common in children <5 years of age.

Conclusion:
MRI is extremely useful in the early detection and diagnosis of the causes of seizures in children in low socio-economic setting like ours. The majority of the children with brain lesions were under five years, and in a setting like ours, all efforts should be made to image them since they are sometimes denied MRI due to the relatively high cost of the procedure.
Multiparametric differentiation of intracranial central nervous system lymphoma and high-grade glioma using diffusion-, perfusion-, susceptibility-weighted magnetic resonance imaging, and spectroscopy
Authors: Rai Santosh , Raeesa Fathima , Kamath Mayur , Rai Sharada , Pai Muralidhar K. , Prabhu Sonali D. 
Published: November 2022

Aims and Objectives:
To observe the characteristics of primary central nervous system lymphoma (PCNSL) and high-grade glioma (HGG) in diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), susceptibility-weighted imaging (SWI) and spectroscopy, and differentiate them based on these parameters.

Materials and Methods:
A total of 45 patients diagnosed with the central nervous system (CNS) neoplasm on magnetic resonance imaging (MRI) using 1.5 Tesla MRI Siemens Magnetom Avanto (Siemens, Germany) and with subsequent histopathological evidence as glioblastoma or CNS lymphoma were included. The study was completed over a period of 2 years.

Results:
It was found that DWI is effective in the differentiation of HGGs and PCNSLs. A total of 20 (57.1%) HGGs showed diffusion restriction, whereas 9 (90%) of the PCNSLs showed diffusion restriction. The mean apparent diffusion coefficient (ADC) (×10–6 mm2/s) in PCNSLs was 646 whereas, in HGGs, it was found to be 824.3. Thirty-one (88.6%) of the HGGs showed increased perfusion. The mean value of rCBVmean in HGG was found to be 4.06 and the mean value of rCBVmax was 3.63. None of the PCNSLs showed increased perfusion. The mean value of rCBVmean in PCNSLs was 0.097 and rCBVmax was 0.133. 30 (85.7%) of HGGs showed significant areas of blooming on SWI (in the form of intratumoral susceptibility signals [ITSS]). None of the PCNSLs showed blooming. All HGGs and PCNSLs showed increased choline and decreased N acetyl aspartate (NAA) on spectroscopy. Mean Choline/Creatine (Cho/Cr) in HGGs was found to be 3.06, whereas in PCNSLs, it was 1.84.

Conclusion:
It is important to make a distinction between HGG and PCNSL as the treatment modalities are different for both. Multiparametric evaluation of ADC, ITSS, and rCBVmean allows the differentiation of PCNSLs and solid glioblastoma which supports the integration of advanced MR imaging techniques including DSC-PWI, DWI, and SWI for the routine diagnostic workup of these tumors.