bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Efficacy of Selective, Clopidogrel-Based Strategies in Acute Coronary Syndrome: A Study-Level Meta-analysis
Authors: Patti Giuseppe , Grisafi Leonardo , Spinoni Enrico Guido , Rognoni Andrea , Mennuni Marco 
Published: April 2022

Abstract
Objectives To investigate outcomes with selective, clopidogrel-based therapies versus conventional treatment in patients undergoing percutaneous coronary intervention (PCI), especially for acute coronary syndrome.
Background Safety and efficacy of alternative, selective, clopidogrel-based therapies after PCI are not robustly established.
Methods We performed a study-level meta-analysis on six randomized trials investigating selective clopidogrel-based therapies (three on unguided de-escalation, N = 3,473; three on guided clopidogrel therapy, N = 7,533). Control groups received ticagrelor or prasugrel treatment. Main endpoints were major bleeding, any bleeding, major adverse cardiovascular events (MACE), and net clinical endpoint.
Results The incidence of major bleeding and MACE was similar in the selective, clopidogrel-based therapy versus the conventional treatment arm (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.51–1.01, p = 0.06; OR: 0.93, 0.72–1.20, p = 0.58; respectively). The rates of any bleeding were lower in the selective, clopidogrel-based therapy versus conventional treatment group (OR: 0.57, 95% CI: 0.40–0.80, p = 0.001); this greater safety was significant for unguided de-escalation (OR: 0.43, 95% CI: 0.32–0.58, p = 0.00001) and nonsignificant for guided clopidogrel therapy (OR: 0.72, 95% CI: 0.51–1.02, p = 0.07; p for interaction: 0.03). The incidence of the net clinical endpoint was fewer in the selective, clopidogrel-based therapy versus the conventional treatment arm (OR: 0.59, 95% CI: 0.41–0.85, p = 0.004); this benefit was significant for unguided de-escalation (OR: 0.50, 95% CI: 0.39–0.64, p < 0.00001) and nonsignificant for guided clopidogrel therapy (OR 0.85, 95% CI: 0.62–1.16, p = 0.30; p for interaction: 0.01).
Conclusion As compared with prasugrel/ticagrelor treatment, alternative, selective, clopidogrel-based approaches provide a similar protection from cardiovascular events, reduce the risk of any bleeding, and are associated with a greater net benefit. These beneficial effects were prevalent with unguided de-escalation to clopidogrel.
Electrochemical C–H Functionalization of Cyclic Amines
Authors: Qiu Youai , Feng Tian , Wang Siyi 
Published: April 2022

AbstractFunctionalized cyclic amines are essential structural motifs in synthetic chemistry and pharmaceutical chemistry, and Shono-type oxidation is a well-developed electrochemical approach for the synthesis of α- amines. In sharp contrast, electrochemically driven direct β-C(sp3)–H functionalization of amines has been far proven elusive. Herein, we outline the recent advances in this field and highlight our group’s effort to achieve electrochemical β-C(sp3)–H functionalization assisted by ferrocene as molecular electrocatalyst under mild conditions.1	Introduction2	Case studies of α-Functionalization (Shono-Type Oxidation)3	Electrochemical β-C(sp3)–H Acylation4	Conclusion
Smoking Prevalence, Attitude, and Cessation Training among Nursing Students in Bhubaneswar, India—A Cross-sectional Study
Authors: Dash Kulumina , Panigrahi Ansuman , Swarupa S. Bhakti , Pathak Mona , Jena Pratap Kumar 
Published: April 2022

Abstract
Introduction The smoking habit of health professionals including nursing students may prevent them from providing cessation advice and counseling to their patients as one cannot persuade others to quit if he/she is smoking himself/herself.
Objective The study aimed to assess the smoking prevalence, attitude, and tobacco cessation training among nursing students.
Materials and Methods During January to April 2019, we conducted a cross-sectional study among 432 third-year nursing students of eight graduate nursing colleges of Bhubaneswar using the Global Health Professional Student Survey (GHPSS) questionnaire.
Results Overall, 38 (8.8%) were current smokers. Majority of participants agreed that health professionals should receive specific training on smoking cessation techniques (91%), serve as role models for their patients and the public (94%), advise their patients to quit tobacco (96.1%). Current smokers were more likely to be males (adjusted OR [aOR]: 6.53, 95% confidence interval or CI: 2.61–16.36), those not supporting a smoking ban in discos/bars/pubs (aOR: 2.82, 95% CI: 1.13–7.05), those lacking knowledge about dangers of smoking (aOR: 2.48, 95% CI: 1.10–5.60), and those not discussing the reasons of smoking (aOR: 2.49, 95% CI: 1.05–5.93).
Conclusion Sincere efforts must be undertaken in the nursing colleges to design and implement strategies to discourage tobacco use among nursing students and adequately train them on tobacco cessation techniques.
Chronic Osteochondral Fractures of the Patella Managed with Open Reduction and Internal Fixation Yields Excellent Knee Function
Authors: Mittal Ravi , Digge Vijay K. , Nayak Tushar 
Published: April 2022

AbstractCurrently, the management of acute osteochondral fractures (OCFs) of the patella is well established. However, the management of chronic OCFs remains debatable, as it is not clear whether such lesions can be accurately reduced or whether they will reliably heal. With well proven results of open reduction and internal fixation (ORIF) with headless compression screws (HCS) for acute OCFs, the application of this technique in late presenting cases is inconclusive. Thus, we present the clinicoradiological outcome of patients with chronic osteochondral injuries managed with ORIF. Fifteen patients who underwent surgical fixation by ORIF with HCS for chronic OCFs of the patella, between February 2013 and June 2018, were retrospectively analyzed after a mean follow-up of 3.8 years (range: 2–7 years). The mode of injury, size of the osteochondral fragment, and knee range of motion along with Kujala's scoring were examined clinically and radiological assessment was done by X-rays and magnetic resonance imaging (MRI) scans. Fifteen patients (11 males and 4 females), with a mean age of 17 years with chronic OCF of patella were enrolled. Noncontact twisting injuries were the most common mode of injury seen in 86.66% of patients and postcontact injuries in two patients (13.33%). The mean time from trauma to presentation was 7 weeks (range: 6–14 weeks). The mean preoperative Kujala's score improved from 44 to 84.8 at 6 months and 92.6 at 2 years, postoperatively. Intraoperatively, the lesion was found in medial patellar facet in 12 patients and 3 had lesions in the central facet. The mean size of the lesion was 20 mm × 18 mm. Radiological union was observed in all patients, at a mean duration of 16 weeks (range: 12–20 weeks). One patient underwent implant removal 1 year after initial surgery for mechanical symptoms. ORIF of OCFs of the patella using headless cannulated screws is simple, reliable, reproducible, and provides satisfactory outcomes. This technique can be considered for fixation of fragments with adequate subchondral bone.
Risk Factors for Foster Care Placement in Patients with Bronchopulmonary Dysplasia
Authors: King Tyler L , Cristea A. Ioana , Slaven James E. , Niehaus Jason Z. 
Published: April 2022

Objective Bronchopulmonary dysplasia (BPD) is a major cause of morbidity in neonates and can be associated with long hospitalization and high health care utilization. This extremely stressful situation can be difficult for many families and caregivers. The high-risk situation combined with increased medical complexity can result in involvement of Department of Child Services (DCS) and even foster care placement. This study seeks to define risk factors for DCS involvement and foster care placement in children with BPD.
Study Design A retrospective study of children born at less than 32 weeks of gestation born between 2010 and 2016, on oxygen at 28 days of life and discharged home from a tertiary care center.
Results A total of 246 patients were identified. DCS was involved in 49 patients with 13 requiring foster care placement. The most common correlated risk factors that were identified for DCS involvement were maternal THC (tetrahydrocannabinol) positivity, hospital policy violations, maternal mental health diagnosis, and home insecurity. Home insecurity (p < 0.005) and amphetamine use (p < 0.005) were associated with foster care placement.
Conclusion There are numerous risk factors for both DCS and foster care placement. The identification of these risk factors is important to help establish services to help families and identify potential biases to avoid.
Key Points
Maximum in density of electrolyte solutions: Learning about ion–water interactions and testing the Madrid-2019 force field
Authors: Sedano L. F. , Blazquez S. , Noya E. G. , Vega C. , Troncoso J. 
Published: April 2022

In this work, we studied the effect of Li+, Na+, K+, Mg2+, and Ca2+ chlorides and sulfates on the temperature of maximum density (TMD) of aqueous solutions at room pressure. Experiments at 1 molal salt concentration were carried out to determine the TMD of these solutions. We also performed molecular dynamics simulations to estimate the TMD at 1 and 2 m with the Madrid-2019 force field, which uses the TIP4P/2005 water model and scaled charges for the ions, finding an excellent agreement between experiment and simulation. All the salts studied in this work shift the TMD of the solution to lower temperatures and flatten the density vs temperature curves (when compared to pure water) with increasing salt concentration. The shift in the TMD depends strongly on the nature of the electrolyte. In order to explore this dependence, we have evaluated the contribution of each ion to the shift in the TMD concluding that Na+, Ca2+, and SO42− seem to induce the largest changes among the studied ions. The volume of the system has been analyzed for salts with the same anion and different cations. These curves provide insight into the effect of different ions upon the structure of water. We claim that the TMD of electrolyte solutions entails interesting physics regarding ion–water and water–water interactions and should, therefore, be considered as a test property when developing force fields for electrolytes. This matter has been rather unnoticed for almost a century now and we believe it is time to revisit it.
Effects of mobile phone use on semen parameters: a cross-sectional study of 1634 men in China
Authors: Zhang Shanshan , Mo Fengyi , Chang Yali , Wu Shufang , Ma Qing , Jin Fan , Xing Lanfeng 
Published: April 2022

Mobile phones play an irreplaceable role in modern people’s lives. However, the radiofrequency electromagnetic radiation produced by mobile phones has also caused increasing concern. A cross-sectional study was conducted to investigate the effect of radiofrequency electromagnetic radiation produced by mobile phones on semen parameters in 1634 men who underwent semen examination at the Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, China. Analysis of variance and multivariate linear regression were used to explore differences among different groups. A P < 0.05 was considered statistically significant. The results showed significant associations among different groups of daily mobile phone use time and daily duration of phone calls in the percentage of progressively motile spermatozoa (P = 0.004 and P = 0.007), rapid progressively motile spermatozoa (P = 0.012 and P = 0.006) and total motile spermatozoa (P = 0.004 and P = 0.046). After adjustments for the confounding effects of age and body mass index by multiple linear regression, the results showed that the daily duration of mobile phone use had a negative effect on sperm motility. However, there was no statistically significant correlation between daily phone call duration and sperm motility. Therefore, the daily duration of mobile phone use may negatively affect sperm motility and impair male fertility.
A discrete KdV equation hierarchy: continuous limit, diverse exact solutions and their asymptotic state analysis
Authors: Liu Xue-Ke , Wen Xiao-Yong 
Published: April 2022

Abstract
In this paper, a discrete KdV equation that is related to the famous continuous KdV equation is studied. First, an integrable discrete KdV hierarchy is constructed, from which several new discrete KdV equations are obtained. Second, we correspond the first several discrete equations of this hierarchy to the continuous KdV equation through the continuous limit. Third, the generalized (m, 2N − m)-fold Darboux transformation of the discrete KdV equation is established based on its known Lax pair. Finally, the diverse exact solutions including soliton solutions, rational solutions and mixed solutions on non-zero seed background are obtained by applying the resulting Darboux transformation, and their asymptotic states and physical properties such as amplitude, velocity, phase and energy are analyzed. At the same time, some soliton solutions are numerically simulated to show their dynamic behaviors. The properties and results obtained in this paper may be helpful to understand some physical phenomena described by KdV equations.
Effect of Enzyme Supplementation in Diet on Growth of Common Carp (Cyprinus carpio L.) juveniles in RAS
Authors: Nasir Noori Abdul-Nabi , Yesser AbdulKareem Taher , Al-Hamadany Qusay Hamid 
Published: April 2022

AbstractThe purpose of this study was to determine the effect of supplementing the diet with Thepax Aqua (Aqualase) on the development and survival of juvenile common carp (Cyprinus carpioL.). Therefore, an eight-week nutrition experiment was carried out using the Thepax Aqura enzyme in the Department of Vertebrates, Marine Science Center, University of Basrah. This enzyme was supplemented at 1, 2, and 3% in the control diet. The maximum weight growth (3.9870 gm 0.1230) and Specific Growth Rate (0.4238 gm 0.0049) were seen in the fish fed with T1 diet, and these results were found to be statistically different (P<0.05) from those observed in the fish fed with T2 (2 %), T3 (3 %), and T0 (control) diets. This study also concluded that there was no significant effect (P≤0.05) for enzyme levels on the survival of juveniles carp fed with different dietary enzymes. Finally, the outcome of the current experiment showed that the 1% supplementation of Thepax Aqua to the food gave good growth and feed utilization of Juveniles of carp C.carpio.
Solid waste: A study of its concept, management methods, and environmental impacts
Authors: Al-Taai Suaad Hadi Hassan 
Published: April 2022

Abstract
The study of the impact of solid waste and its management is one of the important topics that has attracted the attention of researchers and those interested in the study of the environment due to its significant effects on human health, living organisms in general, and the environment. The research has addressed the study of the concept of solid waste and its classification, focusing on domestic, industrial, agricultural, commercial, and other waste. The research also dealt with the study of municipal solid waste, the rate of waste generation, and the factors affecting it. It referred to the physical and chemical composition of solid waste, the arrangement of waste management and its objectives, and the most important stages of waste flow. It discussed the methods of waste collection, sorting, and recycling, the most important human characteristics, and the natural factors affecting them, concerning the negative effects of waste on the environment.
Use Remote Sensing Techniques to Study Epiphytic Algae on Phragmites australis in Um El-Naaj Lake, Mysan Province, Southern Iraq
Authors: Neran A. AL NAQEEB , Jinan S. AL HASSANY , Fouad K. MASHEE 
Published: April 2022

AbstractThe aim of this study was to determine the quality and quantity composition of epiphytic algae ofPhragmites australisin Um El-Naaj lake. Samples were collected from six Stations from November 2018 to October 2019.During this study, a remote sensing techniques was used to monitor the Community of epiphytic algae through storage and management data the geographic information system (GIS) program. The satellite images of the Landsat 8 satellite of the OLI which used to create visual images that facilitate the interpretation of the study area to identification and presence of these species and control their spread.The total number 306 species of epiphytic algae recorded during the study period were, belong to 61 genera. Seasonal variations in total number of species also noticed during the current study, Bacillariophyceae recorded 52.28%, with (160 species of 28 genera), Classes of Chlorophyceae and Cyanophycea recorded 12.67% (39 species of 20 genera 11) and 11.76% (36 species of 12 genera) respectively, while Classes of Fragilarphyceae recorded 14.37% ( 44species of 7genera), Coscinodisphyeceae recorded 13.59% (11 species, 7 genera). Then class of Euglenophyceae with 3.59%., Finally Chrysophyceae, Dinophyceae, and Rhodophyceae recorded 0.32% with 1 species of 1genera as they were present.
Alcohol Intake Influences the Occurrence and Progression of Periodontitis Differently According to Sex and Country Sociodemographic Development: A Two-Stage Systematic Review
Authors: Oliveira Leandro Machado , da Silva Pilecco Kimberly , de Oliveira Cícero Anghinoni , Antoniazzi Raquel Pippi , Demarco Flávio Fernando , Zanatta Fabrício Batistin 
Published: April 2022

Abstract

Aims
To conduct an overview and systematic evaluation of prospective cohort studies on whether alcohol intake is associated with the incidence and progression of periodontitis.

Methods
Nine databases were searched by two independent reviewers up to November 2021 according to prespecified eligibility criteria. Risk of Bias in Systematic Reviews and Risk of Bias in Non-Randomized Studies of Interventions were used for risk of bias assessment and certainty of evidence was assessed using the GRADE approach. Random-effects pair-wise meta-analyses were performed with data from cohort studies on the effects of higher levels of alcohol intake compared with current non-drinking to determine risk ratios (RR) and confidence intervals of periodontitis.

Results
The four systematic reviews were at high risk of bias and concluded that alcohol intake is associated with periodontitis regardless of the study design. Five reports from seven cohort studies contributed to the meta-analyses and no statistically significant differences were found for higher levels of consumption regarding the risk of periodontitis, except for men from countries with low- and high-middle socio-demographic index (RR = 1.30, 95% CI: 1.13–1.46), with low certainty evidence.

Conclusion
Higher levels of alcohol consumption seem to be part of the causal mechanism of periodontitis when cooccurring with male sex in underdeveloped countries. No conclusion can be drawn regarding alcohol use disorders or patterns of consumption.
Tightly integrated multiomics-based deep tensor survival model for time-to-event prediction
Authors: Zhang Jasper Zhongyuan , Xu Wei , Hu Pingzhao 
Published: April 2022

AbstractMotivationMultiomics cancer profiles provide essential signals for predicting cancer survival. It is challenging to reveal the complex patterns from multiple types of data and link them to survival outcomes. We aim to develop a new deep learning-based algorithm to integrate three types of high-dimensional omics data measured on the same individuals to improve cancer survival outcome prediction.ResultsWe built a three-dimension tensor to integrate multi-omics cancer data and factorized it into two-dimension matrices of latent factors, which were fed into neural networks-based survival networks. The new algorithm and other multi-omics-based algorithms, as well as individual genomic-based survival analysis algorithms, were applied to the breast cancer data colon and rectal cancer data from The Cancer Genome Atlas (TCGA) program. We evaluated the goodness-of-fit using the concordance index (C-index) and Integrated Brier Score (IBS). We demonstrated that the proposed tight integration framework has better survival prediction performance than the models using individual genomic data and other conventional data integration methods.Availability and implementationhttps://github.com/jasperzyzhang/DeepTensorSurvivalSupplementary informationSupplementary data are available at Bioinformatics online.
More of the Same, Only Worse: COVID-19 and the Administrative Burdens Facing Loved Ones of Incarcerated Men
Authors: McDonald Alysha D , Berardi Luca , Tetrault Justin E C , Haggerty Kevin D , Bucerius Sandra M 
Published: April 2022

AbstractOver the course of the COVID-19 pandemic, officials have introduced measures to preserve the health of incarcerated individuals and prison employees. To understand the impact of COVID-related correctional policies on individuals with incarcerated friends and family members, we conducted 181 longitudinal interviews from April 2020 to January 2021 with 29 such ‘loved ones.’ Participants emphasized concerns about (1) health and safety; (2) unclear, unpredictable and untrusted communications; and (3) diminished personal intimacy. We analyze these findings using an ‘administrative burden’ framework and discuss possible reforms. We also suggest a wider applicably of this framework for studying individuals who have diverse encounters with the criminal justice system.
Temporal Dynamics of Nasopharyngeal and Tracheal Severe Acute Respiratory Syndrome Coronavirus 2 Cycle Thresholds in Coronavirus Disease 2019 Patients With Tracheostomy
Authors: Long Sallie M , Chern Alexander , Cooley Victoria , Chung Sei , Feit Noah Z. , Craney Arryn , Simon Matthew S , Tassler Andrew B 
Published: April 2022

Abstract
In this study of 45 patients with COVID-19 undergoing tracheostomy, nasopharyngeal and tracheal cycle threshold (Ct) values were analyzed. Ct values rose to 37.9 by the time of tracheostomy and remained &gt;35 postoperatively, demonstrating that persistent test positivity may not be associated with persistent transmissible virus in this population.