bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the impact of social determinants, conditional cash transfers and primary health care on HIV/AIDS: Study protocol of a retrospective and forecasting approach based on the data integration with a cohort of 100 million Brazilians
Authors: Rasella Davide , Morais Gabriel Alves de Sampaio , Anderle Rodrigo Volmir , Silva Andréa Ferreira da , Lua Iracema , Coelho Ronaldo , Rubio Felipe Alves , Magno Laio , Machado Daiane , Pescarini Julia , Souza Luis Eugênio , Macinko James , Dourado Inês 
Published: March 2022

Background
Despite the great progress made over the last decades, stronger structural interventions are needed to end the HIV/AIDS pandemic in Low and Middle-Income Countries (LMIC). Brazil is one of the largest and data-richest LMIC, with rapidly changing socioeconomic characteristics and an important HIV/AIDS burden. Over the last two decades Brazil has also implemented the world’s largest Conditional Cash Transfer programs, the Bolsa Familia Program (BFP), and one of the most consolidated Primary Health Care (PHC) interventions, the Family Health Strategy (FHS).

Objective
We will evaluate the effects of socioeconomic determinants, BFP exposure and FHS coverage on HIV/AIDS incidence, treatment adherence, hospitalizations, case fatality, and mortality using unprecedently large aggregate and individual-level longitudinal data. Moreover, we will integrate the retrospective datasets and estimated parameters with comprehensive forecasting models to project HIV/AIDS incidence, prevalence and mortality scenarios up to 2030 according to future socioeconomic conditions and alternative policy implementations.

Methods and analysis
We will combine individual-level data from all national HIV/AIDS registries with large-scale databases, including the “100 Million Brazilian Cohort”, over a 19-year period (2000–2018). Several approaches will be used for the retrospective quasi-experimental impact evaluations, such as Regression Discontinuity Design (RDD), Random Administrative Delays (RAD) and Propensity Score Matching (PSM), combined with multivariable Poisson regressions for cohort analyses. Moreover, we will explore in depth lagged and long-term effects of changes in living conditions and in exposures to BFP and FHS. We will also investigate the effects of the interventions in a wide range of subpopulations. Finally, we will integrate such retrospective analyses with microsimulation, compartmental and agent-based models to forecast future HIV/AIDS scenarios.

Conclusion
The unprecedented datasets, analyzed through state-of-the-art quasi-experimental methods and innovative mathematical models will provide essential evidences to the understanding and control of HIV/AIDS epidemic in LMICs such as Brazil.
Rock Star/Movie Star: Power and Performance in Cinematic Rock Stardom, Landon Palmer (2020)
Authors: Sammartino Eleonora 
Published: March 2022

Review of: Rock Star/Movie Star: Power and Performance in Cinematic Rock Stardom, Landon Palmer (2020)
New York: Oxford University Press, 274 pp.,
IBSN 978-0-19088-841-1, p/bk £22.99
Cybernetics of the Poor, Diedrich Diederichsen and Oier Etxeberria (eds) (2021)
Authors: Arar Raphael 
Published: March 2022

Review of: Cybernetics of the Poor, Diedrich Diederichsen and Oier Etxeberria (eds) (2021)
Dijon: Les Presses du réel, 264 pp.,
ISBN 978-3-95679-593-0, p/bk, $24.95
Financial Literacy and Economic Growth: How Eastern Europe is Doing?
Authors: Pașa Adina Teodora , Picatoste Xose , Gherghina Elena Mădălina 
Published: March 2022

AbstractIn this study, we aim to analyse financial literacy as a driver of financial wellbeing and economic growth in three of the most recent EU Member States, namely Romania, Bulgaria, and Croatia. Our particular interest in studying more in-depth these three countries is generated by their difficult pathway in the transition to the Euro and economic convergence on one side and by the limited analysis carried out so far in relation to them on the other side. Various studies indicate that financial literacy is associated with wealth accumulation, and financial education can help achieve economic growth. To conduct the empirical analysis, in this study, we have used primary data provided by the OECD for our specific research purposes. The raw data were collected in a survey carried out in 2019 in seven South Eastern European countries reaching over 1,000 respondents for each country. We used two-stage least-squares regression to test our hypothesis and cluster analysis for comparisons among countries. Conclusions of our research reveal the main differences between countries in terms of financial literacy and reverse causality between financial literacy and economic growth for the analysed countries. Finally, the study gives some insights into the future design of public policies on financial education in these countries.
Crystal structure of (2,2′-((naphthalen-1-ylmethyl)azanediyl)diacetato-κ3
N,O,O′)-(1,10-phenanthroline-κ2
N,N′)-copper(II) trihydrate, CuC27H27N3O7
Authors: Xu Xingman , Sun Renqiang 
Published: March 2022

Abstract
CuC27H27N3O7, orthorhombic, Pca21 (no. 29), a = 22.9142(18) Å, b = 7.3271(6) Å, c = 14.7386(11) Å, V = 2474.5(3) Å3, Z = 4, R

gt
(F) = 0.0443, wR

ref
(F
2) = 0.0990, T = 294(2) K.
Nonlinear dynamic and crack behaviors of carbon nanotubes-reinforced composites with various geometries
Authors: Maharjan Ashish , Yu Piljo , Lee Sang-Youl 
Published: March 2022

Abstract
This study carried out finite element dynamic analyses of carbon nanotubes/fiber/polymer composites (CNTFPC) with various geometries. In the first application, the effects of CNTs on the nonlinear transient responses of doubly curved shells for various cutout sizes and curvatures are studied. The numerical results obtained are in good agreement with those reported by other investigators. For the practical application, the focus of this study is to evaluate various performances of concrete structures reinforced with a rebar-type CNTFPC. The new results reported in this article show the interactions between CNT weight ratios and crack sizes in CNTFPC-reinforced concrete structures. Key observation points are discussed and a brief design guideline is given.
The Eneolithic cemetery at Khvalynsk on the Volga River
Authors: Anthony David W. , Khokhlov A. A. , Agapov S. A. , Agapov D. S. , Schulting R. , Olalde I. , Reich D. 
Published: March 2022

Abstract
The genetically attested migrations of the third millennium BC have made the origins and nature of the Yamnaya culture a question of broad relevance across northern Eurasia. But none of the key archaeological sites most important for understanding the evolution of Yamnaya culture is published in western languages. These key sites include the fifth-millennium BC Khvalynsk cemetery in the middle Volga steppes. When the first part of the Eneolithic cemetery (Khvalynsk I) was discovered in 1977–1979, the graves displayed many material and ritual traits that were quickly recognized as similar and probably ancestral to Yamnaya customs, but without the Yamnaya kurgans. With the discovery of a second burial plot (Khvalynsk II) 120 m to the south in 1987–1988, Khvalynsk became the largest excavated Eneolithic cemetery in the Don-Volga-Ural steppes (201 recorded graves), dated about 4500–4300 BCE. It has the largest copper assemblage of the fifth millennium BC in the steppes (373 objects) and the largest assemblage of sacrificed domesticated animals (at least 106 sheep-goat, 29 cattle, and 16 horses); and it produced four polished stone maces from well-documented grave contexts. The human skeletons have been sampled extensively for ancient DNA, the basis for an analysis of family relationships. This report compiles information from the relevant Russian-language publications and from the archaeologists who excavated the site, two of whom are co-authors, about the history of excavations, radiocarbon dates, copper finds, domesticated animal sacrifices, polished stone maces, genetic and skeletal studies, and relationships with other steppe cultures as well as agricultural cultures of the North Caucasus (Svobodnoe-Meshoko) and southeastern Europe (Varna and Cucuteni-Tripol’ye B1). Khvalynsk is described as a coalescent culture, integrating and combining northern and southern elements, a hybrid that can be recognized genetically, in cranio-facial types, in exchanged artifacts, and in social segments within the cemetery. Stone maces symbolized the unification and integration of socially defined segments at Khvalynsk.
Influence of ettringite on the crack self-repairing of cement-based materials in a hydraulic environment
Authors: Zhang Yanfang , Wang Anhui , Zhan Qiwei , Zhou Juanlan , Zhang Yongsheng , Gu Weiyang 
Published: March 2022

Abstract
As a green and environmental protection method, the self-repairing technology has great expectations to be met. In this study, the influence of ettringite on the crack self-repairing of cement-based materials in a hydraulic environment was systematically analyzed. First, the composition and pore characteristics of the self-repairing carrier was studied by XRD, XRF, and the mercury injection method. The composition was basically consistent with cement-based materials, and the structure of the self-repairing carrier was relatively dense. Second, the products were analyzed by SEM and EDS, and it was found that the distribution range of crystal size was from 1 to 20 µm, the cube and flocculent accumulation was calcite, while the rod and flake crystals were ettringite. Finally, the repair effect on the surface and inside of the crack was demonstrated by the crack area repair rate and water permeability resistance. Compared with single microbial mineralization, the synergistic repair effect of microbial mineralization and ettringite formation was better in water permeability resistance. With the further increase of water pressure, its advantages would be more obvious.
Long-term opioid treatment and endocrine measures in patients with cancer-related pain: a systematic review
Authors: Abou-Kassem Dalia , Kurita Geana P. , Sjøgren Per , Diasso Pernille D. K. 
Published: March 2022

Abstract

Objectives
Opioid analgesics are the main stay for cancer pain management; however, long-term opioid treatment (L-TOT) may suppress the endocrine system. This systemic review aimed at investigating effects of L-TOT on the endocrine system in patients with cancer-related pain.

Methods
A search on MEDLINE, EMBASE and Web of Science databases was performed. Inclusion criteria were clinical studies investigating endocrine measures in adult patients with cancer-related pain in L-TOT (≥4 weeks). Outcomes and quality of evidence were assessed.

Results
A total of 252 abstracts were identified; out of which 247 were excluded and five cross-sectional studies were included and analyzed. L-TOT was associated with lower serum concentration levels of total- and free testosterone in males, follicular stimulating hormone in females, and luteinizing hormone in both sexes. Moreover, higher morphine equivalent daily doses (MEDDs) were correlated with higher levels of cortisol and lower levels of LH in both sexes, and lower levels of total- and free testosterone in males. Sexual dysfunction was associated with low sex hormone levels. Level of evidence was low/very low.

Conclusions
The studies identified demonstrated that patients with cancer-related pain in L-TOT may have gonadal hypofunction causing sexual dysfunction, which may be correlated with opioid dose level. In addition, high serum concentrations of cortisol were positively correlated with high opioid dose levels. However, the evidence was weak and further research is necessary. PROSPERO, ID-number: CRD42020213059.
Diagnose des Produktionsfaktors Information
Authors: Mertens Sven , Magdeburg Jörg 
Published: March 2022

Abstract
Erfolgreiches Informationsmanagement ist kein Zufallsprodukt des betrieblichen Geschehens, sondern ein Ergebnis einer bedarfsorientierten Informationsstrukturgestaltung. Der Artikel beschreibt die Methode einer Kommunikationsdiagnostik, deren Zielsetzung die Gestaltung der Ablauf- und Aufbauorganisation sowie im Anschluß deren technische Unterstützung ist.
Die partizipative Fabrik
Authors: Kuhn Axel , Beckmann Holger 
Published: March 2022

Abstract
Angesichts des globalen Wettbewerbs gilt es, Standortvorteile konsequent zu nutzen. Das im folgenden dargelegte Konzept der partizipativen Fabrik skizziert hierzu einen Ansatz, der insbesondere für kleine und mittlere Unternehmen bedenkenswert erscheint. Dabei wird aufgezeigt, wie sie durch eine spezifische Art der Kooperation ihre Wettbewerbsposition nachhaltig verbessern können.
Prozeßmanager stabilisieren den BPR-Erfolg
Authors: Binner Hartmut F. 
Published: March 2022

Abstract
Die intensive Auseinandersetzung mit den Ansatzpunkten des Lean Management und der Lean Production haben deutlich gemacht, daß sich das bisherige Paradigma der Organisationslehre verändert hat. Das in diesem Beitrag beschriebene integrierte Organisations- und Prozeßmanagement nach dem CIM-house-Vorgehensmodell mit dem Sycat-Tool zielt auf die Umsetzung notwendiger Neuorganisationen und die Durchsetzung schlanker Unternehmensstrukturen.
Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes
Authors: Chen Min , Ohm Daniel T. , Phillips Jeffrey S. , McMillan Corey T. , Capp Noah , Peterson Claire , Xie Emily , Wolk David A. , Trojanowski John Q. , Lee Edward B. , Gee James , Grossman Murray , Irwin David J. 
Published: March 2022

Network analyses inform complex systems such as human brain connectivity, but this approach is seldom applied to gold-standard histopathology. Here, we use two complimentary computational approaches to model microscopic progression of the main subtypes of tauopathy versus TDP-43 proteinopathy in the human brain. Digital histopathology measures were obtained in up to 13 gray matter (GM) and adjacent white matter (WM) cortical brain regions sampled from 53 tauopathy and 66 TDP-43 proteinopathy autopsy patients. First, we constructed a weighted non-directed graph for each group, where nodes are defined as GM and WM regions sampled and edges in the graph are weighted using the group-level Pearson's correlation coefficient for each pairwise node comparison. Additionally, we performed mediation analyses to test mediation effects of WM pathology between anterior frontotemporal and posterior parietal GM nodes. We find greater correlation (i.e., edges) between GM and WM node pairs in tauopathies compared with TDP-43 proteinopathies. Moreover, WM pathology strongly correlated with a graph metric of pathology spread (i.e., node-strength) in tauopathies (r= 0.60,p< 0.03) but not in TDP-43 proteinopathies (r= 0.03,p= 0.9). Finally, we found mediation effects for WM pathology on the association between anterior and posterior GM pathology in FTLD-Tau but not in FTLD-TDP. These data suggest distinct tau and TDP-43 proteinopathies may have divergent patterns of cellular propagation in GM and WM. More specifically, axonal spread may be more influential in FTLD-Tau progression. Network analyses of digital histopathological measurements can inform models of disease progression of cellular degeneration in the human brain.SIGNIFICANCE STATEMENTIn this study, we uniquely perform two complimentary computational approaches to model and contrast microscopic disease progression between common frontotemporal lobar degeneration (FTLD) proteinopathy subtypes with similar clinical syndromes during life. Our models suggest white matter (WM) pathology influences cortical spread of disease in tauopathies that is less evident in TDP-43 proteinopathies. These data support the hypothesis that there are neuropathologic signatures of cellular degeneration within neurocognitive networks for specific protienopathies. These distinctive patterns of cellular pathology can guide future efforts to develop tissue-sensitive imaging and biological markers with diagnostic and prognostic utility for FTLD. Moreover, our novel computational approach can be used in future work to model various neurodegenerative disorders with mixed proteinopathy within the human brain connectome.
BUSINESS PLANNING TRAINING PROGRAM TO DEVELOP ENTREPRENEURIAL INTERESTS OF THE YOUNGER GENERATION IN TEGALSARI VILLAGE OF TEGALSARI CITY
Authors: Habibi Beni , Apriani Dewi , Yulianto A. Rony 
Published: March 2022

A step is needed to build entrepreneurial interests of the younger generation, one of which is to create a program that accommodates the aspirations of generations to increase their business interests, namely through entrepreneurial training programs. Business planning training program for the younger generation is done in Tegalsari Village, Tegalsari. This business planning training program aims to increase entrepreneurial interest for young people and guide the business preparation process ranging from the introduction of types of businesses to the preparation of businesses through examples of businesses made by participants. Based on the results of the training activities that have been carried out, it can be drawn as follows. Participants' knowledge of entrepreneurship is very strong as seen from pre-test and post-test results. This result is quite proud because most participants are participants who have received entrepreneurial counseling in the previous year. The delivery of knowledge about the preparation of business planning can improve the knowledge and understanding of participants about the objectives and benefits and the importance of making business planning before deciding to be entrepreneurial
Diperlukan sebuah langkah untuk membangun minat berwirausaha para generasi muda yaitu salah satunya dengan membuat sebuah program yang menampung aspirasi para generasi untuk meningkatkan minat usahanya yaitu melalui program pelatihan kewirausahaa. Program pelatihan perencanaan usaha untuk generasi muda ini di lakukan di kelurahan Tegalsari Kota Tegal. Program pelatihan perencanaan usaha ini bertujuan untuk meningkatkan minat wirausaha bagi kalangan muda dan membimbing proses penyusunan usaha mulai dari pengenalan jenis â€“ jenis usaha sampai dengan menyusun usaha melalui contoh usaha yang dibuat oleh peserta. Berdasarkan hasil pelaksanaan kegiatan pelatihan yang telah dilakukan, dapat ditarik simpulan sebagai berikut. Pengetahuan peserta mengenai kewirausahaan tergolong sangat kuat yang terlihat dari hasil pre-test dan post-test. Hasil ini cukup membanggakan karena sebagian besar peserta adalah peserta yang telah mendapatkan penyuluhan kewirausahaan pada tahun sebelumnya. Penyampaian pengetahuan tentang penyusunan perencanaan usaha dapat meningkatkan pengetahuan dan pemahaman peserta mengenai tujuan dan manfaatnya serta pentingnya membuat perencanaan usaha sebelum memutuskan berwirausaha.
RAISING AWARENESS OF VILLAGE ARCHIVES ORDERLY THROUGH RECORD MANAGEMENT ASSISTANCE PROGRAM BASED ON SIMULATION VIDEO
Authors: Ismiyati Ismiyati , Pramusinto Hengky , Marimin Marimin , Handayani Bestari Dwi , Sholikah Mar'atus 
Published: March 2022

Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan aparatur desa dan meningkatkan kesadaran akan pentingnya tertib arsip di Desa Kenteng. Upaya meningkatkan keterampilan dan kesadaran aparat desa dalam mengelola arsip sesuai kaidah yang berlaku dilakukan melalui pendampingan teknis penataan arsip sesuai kaidah kearsipan di lingkungan pemerintahan. Hasil dari kegiatan masyarakat ini menunjukkan partisipasi peserta sangat tinggi dalam kegiatan webinar record management. Kegiatan webinar berkaitan dengan teknik penataan arsip. Kegiatan webinar dimaksudkan sebagai pengganti kegiatan sosialisasi secara langsung, karena masa pandemi COVID-19 mengharuskan segala bentuk kegiatan tatap muka dikurangi. Untuk itu, kegiatan pengabdian dilakukan dengan acara webinar. Setelah diberikan webinar, dilanjutkan dengan pendampingan teknis kearsipan dengan cara simulation video di lapangan tentang penataan kembali arsip sesuai klasifikasi yang ada, dengan tujuan agar aparatur desa tertib akan arsip. Selain itu, arsip yang dibutuhkan dapat mudah ditemukan kembali. Evaluasi kegiatan webinar dan pendampingan penataan arsip ini menunjukkan bahwa seluruh aparatur desa menunjukkan peningkatan dalam kemampuan dan kesadaran terhadap tertib arsip desa.
The purpose of this community service activity is to increase the knowledge of village apparatus and raise awareness of the importance of orderly archives in Kenteng Village. Efforts to improve the skills and awareness of village officials in managing archives in accordance with applicable rules are carried out through technical assistance in the arrangement of archives in accordance with archival rules in the government environment. The results of this community activity showed very high participation of participants in record management webinar activities. Webinar activities related to archival structuring techniques. Webinar activities are intended as a substitute for direct socialization activities, as the COVID-19 pandemic requires all forms of face-to-face activities to be reduced. Therefore, devotional activities are carried out with webinar events. After being given a webinar, followed by archival technical assistance by means of simulation video in the field about the rearranging of archives according to existing classifications, with the aim of orderly village apparatus will archive. In addition, the required archives can be easily rediscovered. Evaluation of webinar activities and assistance in the arrangement of this archive shows that all village apparatus shows improvement in the ability and awareness of the orderly village archives.
Impact of GH administration on skeletal endpoints in adults with overweight/obesity
Authors: Dichtel Laura E , Haines Melanie S , Gerweck Anu V , Bollinger Bryan , Kimball Allison , Schoenfeld David , Bredella Miriam A , Miller Karen K 
Published: March 2022

Objective
Overweight/obesity is associated with relative growth hormone (GH) deficiency and increased fracture risk. We hypothesized that GH administration would improve bone endpoints in individuals with overweight/obesity.

Design
An 18-month, randomized, double-blind, placebo-controlled study of GH, followed by 6-month observation.

Methods
In this study, 77 adults (53% men), aged 18–65 years, BMI ≥ 25 kg/m2, and BMD T- or Z-score ≤ −1.0 were randomized to daily subcutaneous GH or placebo, targeting IGF1 in the upper quartile of the age-appropriate normal range. Forty-nine completed 18 months. DXA, volumetric quantitative CT, and high-resolution peripheral quantitative CT were performed.

Results
Pre-treatment mean age (48 ± 12 years), BMI (33.1 ± 5.7 kg/m2), and BMD were similar between groups. P1NP, osteocalcin, and CTX increased (P < 0.005) and visceral adipose tissue decreased (P = 0.04) at 18 months in the GH vs placebo group. Hip and radius aBMD, spine and tibial vBMD, tibial cortical thickness, and radial and tibial failure load decreased in the GH vs placebo group (P < 0.05). Between 18 and 24 months (post-treatment observation period), radius aBMD and tibia cortical thickness increased in the GH vs placebo group. At 24 months, there were no differences between the GH and placebo groups in bone density, structure, or strength compared to baseline.

Conclusions
GH administration for 18 months increased bone turnover in adults with overweight/obesity. It also decreased some measures of BMD, bone microarchitecture, and bone strength, which all returned to pre-treatment levels 6 months post-therapy. Whether GH administration increases BMD with longer treatment duration, or after mineralization of an expanded remodeling space post-treatment, requires further investigation.