bluuebunny/crossref_metadata_2025_split huggingface dataset:
The differential impact of duration of untreated psychosis on functioning and quality of life: A threshold analysis
Authors: Golay Philippe , Ramain Julie , Mebdouhi Nadir , Abrahamyan Empson Lilith , Elowe Julien , Solida Alessandra , Conus Philippe 
Published: June 2022

AbstractAimReduction of duration of untreated psychosis (DUP) remains a key goal of early intervention programs. While a significant body of literature suggests that a short DUP has a positive impact on outcome, little is known regarding the threshold above which various dimensions of outcome are impaired. In this study, we explore the DUP threshold that best discriminates subgroups with poorer outcome regarding global functioning and quality of life after 3 years of treatment.MethodA total of 432 patients were followed‐up prospectively over 3 years. Several hypothetical cut‐off points for DUP were tested in order to maximize differences in effect size for quality of life and general functioning.ResultsWhile a DUP cut‐off of 86 weeks defined two subpopulations with a difference of greatest effect size in quality of life after 3 years, it is already at a cut‐off of 3 weeks of DUP that two subpopulations with a difference in global functioning of the greatest effect size was reached.ConclusionDUP seems to have a differential impact on the various components of outcome, and in particular on quality of life and global functioning. Our data suggest that aiming at very short DUP is justified, but that DUP over 3 weeks are still compatible with good quality of life after 3 years of treatment.
Bidirectional longitudinal relationships between parents' marital satisfaction, parenting stress, and self‐compassion in China
Authors: Wang Die , Xie Ruibo , Ding Wan , Yuan Zhifan , Kayani Sumaira , Li Weijian 
Published: June 2022

AbstractAbundant research has shown that self‐compassion robustly contributes to adults' psychological well‐being. Meanwhile, a few studies have shown that self‐compassion is rooted in early experiences with parents. However, it is unclear whether interactions with partners and children affect adults' self‐compassion, and the role of their self‐compassion in interactions with significant others. This study examined bidirectional longitudinal relationships between Chinese parents' marital satisfaction, parenting stress, and self‐compassion following a three‐wave longitudinal design. A sample of 322 Chinese father–mother dyads (father's Mage = 35.84, SDage = 5.76; mother's Mage = 34.32, SDage = 5.46) completed a set of questionnaires at three time points. The results showed that marital satisfaction positively predicted the fathers' and mothers' self‐compassion, while parenting stress did not significantly predict the parents' self‐compassion; In contrast, parents' self‐compassion did not significantly predict marital satisfaction or parenting stress. Additionally, there was a bidirectional relationship between marital satisfaction and parenting stress in fathers and mothers. Finally, mothers' marital satisfaction positively mediated the relationship between parenting stress and self‐compassion/next‐stage parenting stress. This study revealed that adults' self‐compassion can develop from caring and supportive relationships, including marital relationships. Highlighting key mechanisms of marital satisfaction, such as increasing self‐compassion and reducing parenting stress, may contribute to the improvement of adults' mental health.
The role of continental shelf bathymetry in shaping marine range shifts in the face of climate change
Authors: Kitchel Zoë J. , Conrad Hailey M. , Selden Rebecca L. , Pinsky Malin L. 
Published: June 2022

AbstractAs a consequence of anthropogenic climate change, marine species on continental shelves around the world are rapidly shifting deeper and poleward. However, whether these shifts deeper and poleward will allow species to access more, less, or equivalent amounts of continental shelf area and associated critical habitats remains unclear. By examining the proportion of seabed area at a range of depths for each large marine ecosystem (LME), we found that shelf area declined monotonically for 19% of LMEs examined. However, the majority exhibited a greater proportion of shelf area in mid‐depths or across several depth ranges. By comparing continental shelf area across 2° latitudinal bands, we found that all coastlines exhibit multiple instances of shelf area expansion and contraction, which have the potential to promote or restrict poleward movement of marine species. Along most coastlines, overall shelf habitat increases or exhibits no significant change moving towards the poles. The exception is the Southern West Pacific, which experiences an overall loss of area with increasing latitude. Changes in continental shelf area availability across latitudes and depths are likely to affect the number of species local ecosystems can support. These geometric analyses help identify regions of conservation priority and ecological communities most likely to face attrition or expansion due to variations in available area
Transarterial chemoembolization combined with lenvatinib versus transarterial chemoembolization combined with sorafenib for unresectable hepatocellular carcinoma: A comparative retrospective study
Authors: Zhang Jin‐Xing , Chen Yu‐Xing , Zhou Chun‐Gao , Liu Jin , Liu Sheng , Shi Hai‐Bin , Zu Qing‐Quan 
Published: June 2022

AbstractAimTyrosine kinase inhibitors target transarterial chemoembolization (TACE)‐mediated vascular endothelial growth factor to inhibit tumor revascularization and to slow tumor progression. The present study aimed to compare the clinical outcomes of TACE combined with lenvatinib (TACE‐lenvatinib) and TACE combined with sorafenib (TACE‐sorafenib) in patients with unresectable hepatocellular carcinoma (HCC).MethodsThe clinical data of patients diagnosed with unresectable HCC who received TACE‐lenvatinib or TACE‐sorafenib between January 2018 and April 2021 were retrospectively reviewed. The tumor response, progression‐free survival (PFS), overall survival (OS), and adverse events (AEs) were evaluated and compared between the two groups.ResultsA total of 112 patients were enrolled and classified into the TACE‐lenvatinib group (n = 53) and the TACE‐sorafenib group (n = 59). The objective response rates of patients in the TACE‐lenvatinib and TACE‐sorafenib groups were 54.7% and 44.1%, respectively (p = 0.260), and the disease control rates (DCRs) were 81.1% and 61.0% (p = 0.020). The median PFS time was significantly longer in the TACE‐lenvatinib group than in the TACE‐sorafenib group (10.7 vs. 6.0 months; p = 0.002). The median OS time between the TACE‐lenvatinib and TACE‐sorafenib groups also showed a significant difference (30.5 vs. 20.5 months, p = 0.018). All treatment‐related AEs and grade 3/4 AEs were comparable between the two groups (p > 0.05).ConclusionCompared to TACE‐sorafenib, TACE‐lenvatinib was associated with better DCR, PFS and OS outcomes in patients with unresectable HCC. In subgroups of Barcelona Clinic Liver Cancer B stage or TACE‐refractory patients, TACE‐lenvatinib also showed a trend of superiority.
Prescribing patterns of antiretroviral treatments during pregnancy for women living with HIV in Canada 2004–2020: A surveillance study
Authors: Carvalho Sabrina , Lee Terry , Tulloch Karen J , Sauve Laura J , Samson Lindy , Brophy Jason C , Bitnun Ari , Singer Joel , Money Deborah , Kakkar Fatima , Boucoiran Isabelle ,   for the Canadian Perinatal HIV Surveillance Program (CPHSP)
Published: June 2022

AbstractBackgroundWhile treatment guidelines for HIV in adults have evolved rapidly with the advent of new antiretroviral (ARV) treatment, those for the prevention of vertical HIV transmission in pregnancy have evolved more slowly due to safety and efficacy concerns. Here we describe Canadian prescribing patterns for ARV treatments during pregnancy and compare them to perinatal HIV prescribing guidelines of the United States Department of Health and Human Services (HHS), that are commonly used in Canada and include recommendations for newly commercialized therapies.MethodsThe Canadian Perinatal HIV Surveillance Program (CPHSP) captures annual medical data on mothers living with HIV and their infants from 23 sites across Canada. Women from this cohort who received an ARV treatment during pregnancy and who gave birth between 2004 and 2020 were included in the study. ARV treatments were designated as ‘preferred/alternative’ as per HHS HIV perinatal guidelines, or ‘other than preferred/alternative’.ResultsWe identified 3673 pregnancies from 2720 women. The proportion of women that conceived while on ARV treatment increased from 29% in 2003 to 90% in 2020. Other than preferred/alternative ARV treatments were received in 1112 (30%) of pregnancies and this was significantly associated with having initiated ARV treatment before conception.ConclusionIn Canada during the study period, a high number of women were prescribed an other than preferred/alternative ARV treatment during pregnancy. Further optimization of ARV treatment in women of childbearing age living with HIV is warranted.
Self‐Ownership and the Duty to Assist
Authors: Spafford Jesse 
Published: June 2022

ABSTRACTLibertarians are attracted to the self‐ownership thesis because it seems to satisfy four important theoretical desiderata. First, the thesis treats all persons equally by assigning them the same initial set of rights. Second, the thesis gives people the strongest set of ownership rights possible. Third, it assigns persons a determinate set of rights. And, finally, it grounds the libertarian rejection of a duty to assist, benefit, or rescue others. This article argues that these four desiderata cannot be simultaneously satisfied. Specifically, it contends that the first three desiderata can be jointly satisfied only if the thesis merely gives people the right to include their owned bodies in various actions (as opposed to a stronger version of the thesis that gives people permissions to do things with their bodies). However, such an interpretation of the thesis will not satisfy the final desideratum. Thus, libertarians face a tetralemma when defining the self‐ownership thesis.
The relationship between direct care providers' physical activity behaviour and perceived physical activity needs for people with intellectual disabilities
Authors: Kreinbucher‐Bekerle C. , Melville C. , Wells J. S. G. , Ruf W. 
Published: June 2022

AbstractBackgroundThe promotion of physical activity and the decrease of inactivity and sedentary behaviour are crucial for a healthy lifestyle and positive quality of life. People with intellectual disabilities are at increased risk of inactivity and sedentary behaviour. Therefore, it is important to increase their physical activity by implementing physical activity guidelines in their daily life. Professional direct care providers can play a decisive role in supporting people with intellectual disabilities to participate in physical activity, but the engagement of direct care providers with this role may be reflective of their own attitudes and beliefs towards physical activity. Therefore, the link between the implementation of current physical activity guidelines for people with intellectual disabilities and direct care providers' own beliefs and behaviour with regard to physical activity is investigated.MethodA total of 104 direct care providers completed self‐reported questionnaires about their own physical activity behaviour (IPAQ‐SF), recommendations for people with intellectual disabilities (adaption of EMIQ‐HP) and questions regarding global physical activity guidelines. They were also asked about potential barriers and facilitators for the recommendation of physical activity in open‐ended questions.ResultsPersonal physical activity behaviour is related to the recommended physical activity for people with intellectual disabilities (moderate‐to‐vigorous physical activity: rs = 0.408, P = 0.005). However, recommended physical activity behaviour for people with intellectual disabilities is significantly lower than direct care providers' own physical activity behaviour (P < 0.001). 47.1% of the respondents recommended people with intellectual disabilities to participate in less than the 150 min of moderate intensity physical activity per week for that is recommended in global physical activity guidelines.ConclusionDirect care providers may hold stereotypical views and insecurities about the potential harms associated with people with intellectual disabilities participating in physical activity. Therefore, the dissemination of physical activity recommendations for people with intellectual disabilities should be a major target for health professionals, social workers and scientists to address direct care providers' concerns. Furthermore, we need to emphasise the benefits of regular physical activity to professional direct care providers and directly to people with intellectual disabilities.
Changing Impact of Shocks: A Time‐Varying Proxy SVAR Approach
Authors: MUMTAZ HAROON , PETROVA KATERINA 
Published: June 2022

AbstractIn this paper, we extend the Bayesian Proxy vector autoregression (VAR) model to incorporate time variation in the parameters. A novel Metropolis‐within‐Gibbs sampling algorithm is provided to approximate the posterior distributions of the model's parameters. Using the proposed algorithm, we estimate the time‐varying effects of taxation shocks in the United States and the United Kingdom and find evidence for a decline in the impact of these shocks on output growth.
Credit Crunch and Downward Nominal Wage Rigidities
Authors: ROUILLARD JEAN‐FRANÇOIS 
Published: June 2022

AbstractThrough the lens of a DSGE model, I find that financial shocks in conjunction with downward nominal wage rigidities (DNWR) are important features in explaining the degree of asymmetry that U.S. business cycles exhibit. Financial shocks are constructed as residuals of the borrowing constraint faced by firms in a similar fashion to Jermann and Quadrini (2012). The effects of these shocks on aggregate quantity variables are amplified by DNWR, especially during the global financial crisis. Moreover, my model explains a large part of the upward shift in the labor wedge that occurred during this recession.
Integrative couple treatment for pathological gamblers with an emphasis on forgiveness processes: A case study with three couples
Authors: Côté M. , Dufour M. , Tremblay J. 
Published: June 2022

AbstractGambling's impact on a couple's relationship is an essential element in the gambling disorder (GD). Gamblers tend to lie to their partner to conceal the extent of their gambling problems and debts, which can lead to a serious relational transgression for the couple. One promising avenue is a couple treatment focusing on forgiveness processes. The objective of this study was to determine whether the Integrative Couple Treatment for Pathological Gamblers (ICT‐PG) with an emphasis on forgiveness processes helped couples to enhance these processes. A Single‐Case Research Design (SCRD) was used with three couples in which one of the members had a GD. The results highlight the importance of jointly analyzing the forgiveness processes between the gamblers and their partner, which constantly influenced each other. These promising results illustrate the relevance of integrating forgiveness processes in treatment for couples where one of the members has a GD.
Electrodiagnostic subtyping in Guillain‐Barré syndrome: Use of criteria in practice based on a survey study in IGOS
Authors: Arends Samuel , Drenthen Judith , Van den Bergh Peter Y.K , Hadden Robert D.M. , Shahrizaila Nortina , Dimachkie Mazen M. , Gutiérrez Gutiérrez Gerardo , Katzberg Hans , Kiers Lynette , Lehmann Helmar C. , Péréon Yann , Reisin Ricardo C. , Uncini Antonino , Verhamme Camiel , Waheed Wagar , Cornblath David R. , Jacobs Bart C. ,   the IGOS Electrophysiology Expertise Group
Published: June 2022

AbstractElectrodiagnostic (EDx) studies are helpful in diagnosing and subtyping of Guillain‐Barré syndrome (GBS). Published criteria for differentiation into GBS subtypes focus on cutoff values, but other items receive less attention, although they may influence EDx subtyping: (a) extensiveness of EDx testing, (b) nerve‐specific considerations, (c) distal compound muscle action potential (CMAP)‐amplitude requirements, (d) criteria for conduction block and temporal dispersion. The aims of this study were to investigate how these aspects were approached by neuromuscular EDx experts in practice and how this was done in previously published EDx criteria for GBS. A completed questionnaire was returned by 24 (of 49) members of the electrophysiology expertise group from the International GBS Outcome Study. Six published EDx criteria for GBS subtyping were compared regarding these aspects. The indicated minimal number of motor nerves to study varied among respondents and tended to be more extensive in equivocal than normal studies. Respondents varied considerably regarding usage of compression sites for subtyping (median/wrist, ulnar/elbow, peroneal/fibular head): 29% used all variables from all sites, 13% excluded all sites, and 58% used only some sites and/or variables. Thirty‐eight percent of respondents required a minimal distal CMAP amplitude to classify distal motor latency as demyelinating, and 58% did for motor conduction velocity. For proximal/distal CMAP‐amplitude ratio and F‐wave latency, a requisite minimal CMAP amplitude was more often required (79%). Also, the various published criteria sets showed differences on all items. Practical use of EDx criteria for subtyping GBS vary extensively across respondents, potentially lowering the reproducibility of GBS subtyping.
Expert recommendations on the assessment and management of complications due to hyaluronic acid soft tissue filler injections in Asians
Authors: Wu Yan , An Hi‐Tae , Hsu Nai‐Jen , Loh David , Malaithong Lattaphon , Park Je‐Young , Park Kyungho , Peng Peter Hsien‐Li , Sumaetheiwit Rassapoom , Thammasunthorn Akaluck , Wibowo Almond , Liao Yi‐Hua 
Published: June 2022

AbstractBackgroundThe use of hyaluronic acid (HA) fillers for medical aesthetic purposes is increasing worldwide. Nonetheless, adverse events do occur because of patient‐specific issues, injection technique, or product factors. It would be mandatory to consider cultural and anatomical features of Asians in preventing and managing the complications of HA injections.MethodsLiterature search of studies looking at current evidence and guidelines on the management of complications following HA filler injections in Asian patients was conducted. This was followed by an expert group discussion that was convened to reach consensus recommendations on the best clinical practices.ResultsThe expert panel provided specific recommendations focusing on the safe use of soft tissue fillers in Asian patients, including early identification of adverse events and how to prevent and comprehensively manage these outcomes.ConclusionsHere, we provide consensus statements of Asian experts in dermatology, plastic surgery, ophthalmology, and aesthetic medicine mainly focusing on AEs with higher risk for Asians and can be used to guide physicians in treating Asian population.
Drug delivery of natural products through nano‐carriers for effective vitiligo therapy: A compendia review
Authors: Qadir Abdul , Ullah Shehla Nasar Mir Najib , Jahan Samreen , Ali Asad , Khan Nausheen 
Published: June 2022

AbstractBackgroundVitiligo is a depigmenting illness that causes white areas on the skin. Vitiligo's pathogenetic genesis is based on the melanocyte's autoimmune destruction, in which oxidative stress causes melanocyte molecular, organelle, and exposure of antigen, as well as melanocyte cell death, and so plays a role in vitiligo progression. Natural compounds have recently shown a wide range of therapeutic bioactivities against a number of skin disorders.AimThe aim of this work is drug delivery of natural products through nano‐carriers for effective vitiligo therapy: A compendia review.Methods & MaterialsAn online literature analysis was guided for vitiligo therapy, nanotechnology, phytochemical composition, and, types of vitiligo, types of nanomedicine. Appropriate information were taken from different electronic scientific databases such as Web of Science, Science Direct, Elsevier, Google Scholar, Springer, PubMed, and scripts.ResultsNano‐carriers‐based natural compounds provide a great relationship for the enhancement in the efficacy and safety of pharmacotherapeutic agents for the treatment of vitiligo.DiscussionIn this study focuses on natural compounds' effects and processes on vitiligo models. Although topical therapy plays an important role in vitiligo treatment, its utility and patient compliance are hampered by adverse effects or inadequate efficacy. Novel drug delivery techniques can help improve topical medication delivery by improving epidermal localization, reducing side effects, and increasing effectiveness.ConclusionThis paper covers the significant potential of herbal‐derived active compounds as anti‐vitiligo drugs, as well as new drug delivery as a viable carrier and future possibilities to investigate.
Effectiveness of Internet‐based psychological interventions for treating perinatal depression: A systematic review and meta‐analysis
Authors: Li Lu , Yue Shu‐Wen , Xu Jing , Qiao Jia , Redding Sharon R. , Ouyang Yan‐Qiong 
Published: June 2022

AbstractBackgroundPerinatal depression can result in short‐ and long‐term adverse effects for women and their children if untreated. Psychological interventions, the preferred treatment for most women with perinatal depression, can also be provided online.AimsThis study aimed to provide a comprehensive and systematic review of Internet‐based psychological interventions and to evaluate their effectiveness in the treatment of perinatal depression.DesignSystematic review and meta‐analysis.MethodsA systematic literature search was conducted of six databases, including CINAHL, PubMed, Embase, Web of Science, the Cochrane Library and PsycINFO. Depression and anxiety, which were the primary and secondary results of this search, were presented as standardised mean differences (SMD) and 95% confidence intervals (CIs). This review was conducted according to the PRISMA checklist.ResultsThirteen studies involving 2158 perinatal women were included. Content, method, duration and frequency of Internet‐based psychological interventions were varied. Participants indicated a high rate of satisfaction with these interventions; participants’ dropout rates ranged from 2.6% to 60.8%. Meta‐analysis demonstrated that Internet‐based psychological interventions improved perinatal depression (SMD = −0.72, CI = [−1.02, −0.42], p < .01) and anxiety symptoms (SMD = −0.52, CI = [−0.73, −0.30], p < .01), with heterogeneity of 86% and 59%, respectively.ConclusionsInternet‐based psychological interventions are considered as convenient and effective alternative treatment for perinatal depression and anxiety. In the future, additional studies are needed to investigate the long‐term effects of these interventions on the mental health of perinatal women and the effects on the growth and development of infants while controlling for the dropout rate.Relevance to clinical practiceInternet‐based psychological interventions are innovative approaches to improving perinatal depressive symptoms that can leverage mental health resources and improve accessibility while promoting multidisciplinary integration. The approach, content, frequency and duration of intervention should be considered comprehensively to achieve the objectives of the intervention while maintaining compliance of women with perinatal depression.