bluuebunny/crossref_metadata_2025_split huggingface dataset:
South Africa’s Health Promotion Levy on pricing and acquisition of beverages in small stores and supermarkets
Authors: Ross Alexandra , Swart Elizabeth C , Frank Tamryn , Lowery Caitlin M , Ng Shu Wen 
Published: March 2022

AbstractObjective:In response to concern over rising sugar-sweetened beverage (SSB) consumption, in April 2018, South Africa became the first Sub-Saharan African (SSA) country to implement an SSB tax. We assess changes in pricing and acquisition of beverages from local supermarkets and small stores among 18–39-year-old adults living in one township in the Western Cape, before and after tax implementation. This study is among the first evaluations of an SSB tax on the local food environment in a low-income township.Design:Store beverage pricing and participant surveys were cross-sectional, analysed 1 month before and 11 months after implementation of the tax (March 2018 and March 2019).Setting:Langa, Western Cape, South AfricaParticipants:Surveyed participants were residents of Langa between 18 and 39 years old (n 2693 in 2018 and n 2520 in 2019)Results:Prices of taxed SSB increased significantly among small shops and supermarkets between 2018 and 2019. There were non-significant decreases in prices of untaxed beverages in small shops, but prices of untaxed beverages increased in supermarkets. Across all store types, there was a 9 percentage point decrease in the probability of purchasing regular soda weekly pre/post-implementation. Reductions in purchasing were larger in small shops than supermarkets.Conclusions:We found some differential impacts of the levy on pricing and acquisition of beverages by retailer type in one low-income township. As other SSA countries consider similar fiscal policies to curb soda consumption, obesity and related diseases, this work can be used to understand the implications of these policies in the retail setting.
Legal consciousness and migration: towards a research agenda
Authors: Güdük Ayse , Desmet Ellen 
Published: March 2022

AbstractThis paper reviews scholarship regarding migrants’ legal consciousness. After discussing the personal, geographic and methodological scope of the reviewed studies, the conceptualisation of legal consciousness is examined in light of evolutions in general legal consciousness studies. Thereafter, factors emerging as shaping migrants’ legal consciousness are analytically clustered at four levels: individual characteristics, relational factors, cultural dynamics, and public policies and discourse. Future research on legal consciousness could shift its gaze towards understudied migrant groups as well as places. We suggest being more explicit regarding the conceptualisation of dimensions of what is ‘legal’ and of ‘consciousness’, and adopting a pluralist approach to law. The analytical grouping of the factors impacting migrants’ legal consciousness may serve as a useful reference point for future research and facilitate a more comprehensive appraisal of the various dynamics shaping migrants’ legal consciousness.
Ban on religious symbols in the public service: Quebec’s Bill 21 in a global pluralist perspective
Authors: Mégret Frédéric 
Published: March 2022

AbstractBill 21 is a highly contested law adopted in Quebec that bans certain civil servants from wearing religious symbols in the exercise of their duties. Rather than analyse Bill 21 on its merits, the article treats it as a test case for global legal pluralism, examining how the validity of the law from an international perspective depends on the frames one uses to analyse it. It finds that a basic tension permeates the entire debate between a universalist vision of rights and a vision of rights as anchored in particular political configurations that demand a constant process of adaptation. That tension is visible in the dualist opposition between Canadian and international law; in the role of federalism as a significant mediating factor in the implementation of constitutional and international rights; and in the kind of majoritarian check on rights that manifests itself in the Canadian Charter of Rights’ ‘notwithstanding clause’. Throughout, the article explores how these tensions might be mediated in ways that do not simply oppose international and domestic law but seek to make the most of their interaction.
Biogeosciences Perspectives on Integrated, Coordinated, Open, Networked (ICON) Science
Authors: Dwivedi D. , Santos A. L. D. , Barnard M. A. , Crimmins T. M. , Malhotra A. , Rod K. A. , Aho K. S. , Bell S. M. , Bomfim B. , Brearley F. Q. , Cadillo‐Quiroz H. , Chen J. , Gough C. M. , Graham E. B. , Hakkenberg C. R. , Haygood L. , Koren G. , Lilleskov E. A. , Meredith L. K. , Naeher S. , Nickerson Z. L. , Pourret O. , Song H.‐S. , Stahl M. , Taş N. , Vargas R. , Weintraub‐Leff S. 
Published: March 2022

AbstractThis article is composed of three independent commentaries about the state of Integrated, Coordinated, Open, Networked (ICON) principles in the American Geophysical Union Biogeosciences section, and discussion on the opportunities and challenges of adopting them. Each commentary focuses on a different topic: (a) Global collaboration, technology transfer, and application (Section 2), (b) Community engagement, community science, education, and stakeholder involvement (Section 3), and (c) Field, experimental, remote sensing, and real‐time data research and application (Section 4). We discuss needs and strategies for implementing ICON and outline short‐ and long‐term goals. The inclusion of global data and international community engagement are key to tackling grand challenges in biogeosciences. Although recent technological advances and growing open‐access information across the world have enabled global collaborations to some extent, several barriers, ranging from technical to organizational to cultural, have remained in advancing interoperability and tangible scientific progress in biogeosciences. Overcoming these hurdles is necessary to address pressing large‐scale research questions and applications in the biogeosciences, where ICON principles are essential. Here, we list several opportunities for ICON, including coordinated experimentation and field observations across global sites, that are ripe for implementation in biogeosciences as a means to scientific advancements and social progress.
Tectonic Fabric in the Banda Arc‐Australian Continent Collisional Zone Imaged by Teleseismic Receiver Functions
Authors: Zhang Ping , Miller Meghan S. , Schulte‐Pelkum Vera 
Published: March 2022

AbstractThe convergent plate boundary in eastern Indonesia and Timor‐Leste captures an active oblique collision between the Banda Arc and the Australian plate. We analyzed ∼5 years' worth (2014–2019) of radial and tangential teleseismic Ps receiver functions (RFs) observed at 30 temporary broadband seismic stations across the area. Azimuthal variations in RF arrivals are observed throughout the region, indicative of the presence of oriented tectonic fabrics (dipping contrasts or plunging axis anisotropy) from a variety of crustal depths. The two main strikes of these fabrics are roughly parallel to the orogen and the plate convergence across the outer arc islands, likely associated with orogenic and strike‐slip structures. We observe distinct double polarity‐reversal arrivals with opposite polarity that reflect an anisotropic layer with orogen‐parallel strikes in the shallow crust beneath Timor and Savu, interpreted as metamorphic rocks. Fabrics oriented E‐W are imaged beneath the Flores and Lomblen that host active volcanoes, where we find interesting correlations with magmatic structures. NNW‐SSE striking fabric is imaged at ∼13 km depth beneath central Flores, which relates to a connected dike magmatic system that feeds the aligned cinder cones exposed on the surface. Finally, we identify convergence‐parallel fabrics on the volcano‐extinct islands of Alor and Atauro, consistent with one main fabric orientation imaged in Timor. We suggest all convergence‐parallel fabrics might accommodate strike‐slip motion generated by the overall NNE convergence of the Australian plate with respect to Eurasian plate and contribute to strain partitioning between the trough and backarc resulting from the collision.
Solar Minimum Exospheric Neutral Density Near the Subsolar Magnetopause Estimated From the XMM Soft X‐Ray Observations on 12 November 2008
Authors: Jung J. , Connor H. K. , Carter J. A. , Koutroumpa D. , Pagani C. , Kuntz K. D. 
Published: March 2022

AbstractThe Earth's magnetosheath and cusps emit soft X‐rays due to the charge exchange between highly charged solar wind ions and exospheric hydrogen atoms. The Lunar Environment Heliospheric X‐ray Imager and Solar wind Magnetosphere Ionosphere Link Explorer missions are scheduled to image the Earth's dayside magnetosphere system in soft X‐rays to investigate global‐scale magnetopause reconnection modes under varying solar wind conditions. The exospheric neutral hydrogen density distribution, especially the value of this density at the subsolar magnetopause is of particular interest for understanding X‐ray emissions near this boundary. This paper estimates the exospheric density during solar minimum using the X‐ray Multimirror Mission (XMM) astrophysics observatory. We selected an event on 12 November 2008 from the XMM data archive, which detects soft X‐rays of magnetosheath origin while solar wind and interplanetary magnetic field conditions are relatively constant. During the event the location of the magnetopause was measured in situ by the THEMIS mission, thus the location of the solar wind ions responsible for the magnetosheath emission is well constrained by observation. We estimated the exospheric density using the Open Geospace Global Circulation Model (OpenGGCM) and a spherically symmetric exosphere model. The ratio of the magnetosheath plasma flux between the OpenGGCM model and the THEMIS, was nearly 1, which means the magnetohydrodynamic model reasonably reproduces the magnetosheath plasma conditions. The OpenGGCM magnetosheath parameters were used to deconvolve soft X‐rays of exospheric origin from the XMM signal. The lower‐limit of the exospheric density of this solar minimum event is 36.8 ± 11.7 cm−3 at 10 RE subsolar location.
Properties of Ion‐Inertial Scale Plasmoids Observed by the Juno Spacecraft in the Jovian Magnetotail
Authors: Sarkango Yash , Slavin James A. , Jia Xianzhe , DiBraccio Gina A. , Clark George B. , Sun Weijie , Mauk Barry H. , Kurth William S. , Hospodarsky George B. 
Published: March 2022

AbstractWe expand on previous observations of magnetic reconnection in Jupiter's magnetosphere by constructing a survey of ion‐inertial scale plasmoids in the Jovian magnetotail. We developed an automated detection algorithm to identify reversals in the component and performed the minimum variance analysis for each identified plasmoid to characterize its helical structure. The magnetic field observations were complemented by data collected using the Juno Waves instrument, which is used to estimate the total electron density, and the JEDI energetic particle detectors. We identified 87 plasmoids with “peak‐to‐peak” durations between 10 and 300 s. Thirty‐one plasmoids possessed a core field and were classified as flux‐ropes. The other 56 plasmoids had minimum field strength at their centers and were termed O‐lines. Out of the 87 plasmoids, 58 had in situ signatures shorter than 60 s, despite the algorithm's upper limit being 300 s, suggesting that smaller plasmoids with shorter durations were more likely to be detected by Juno. We estimate the diameter of these plasmoids assuming a circular cross section and a travel speed equal to the Alfven speed in the surrounding lobes. Using the electron density inferred by Waves, we contend that these plasmoid diameters were within an order of the local ion‐inertial length. Our results demonstrate that magnetic reconnection in the Jovian magnetotail occurs at ion scales like in other space environments. We show that ion‐scale plasmoids would need to be released every 0.1 s or less to match the canonical 1 ton/s rate of plasma production due to Io.
The Role of Quartz Cementation in the Seismic Cycle: A Critical Review
Authors: Williams Randolph T. , Fagereng Åke 
Published: March 2022

AbstractBecause quartz veins are common in fault zones exhumed from earthquake nucleation temperatures (150°C–350°C), quartz cementation may be an important mechanism of strength recovery between earthquakes. This interpretation requires that cementation occurs within a single interseismic period. We review slip‐related processes that have been argued to allow rapid quartz precipitation in faults, including: advection of silica‐saturated fluids, coseismic pore‐fluid pressure drops, frictional heating, dissolution‐precipitation creep, precipitation of amorphous phases, and variations in fluid and mineral‐surface chemistry. We assess the rate and magnitude of quartz growth that may result from each of the examined mechanisms. We find limitations to the kinetics and mass balance of silica precipitation that emphasize two end‐member regimes. First, the mechanisms we explore, given current kinetic constraints, cannot explain mesoscale fault‐fracture vein networks developing, even incrementally, on interseismic timescales. On the other hand, some mechanisms appear capable, isolated or in combination, of cementing micrometer‐to‐millimeter thick principal slip surfaces in days to years. This does not explain extensive vein networks in fault damage zones, but allows the involvement of quartz cements in fault healing. These end‐members lead us to hypothesize that high flux scenarios, although more important for voluminous hydrothermal mineralization, may be of subsidiary importance to local, diffusive mass transport in low fluid‐flux faults when discussing the mechanical implications of quartz cements. A renewed emphasis on the controls on quartz cementation rates in fault zones will, however, be integral to developing a more complete understanding of strength recovery following earthquake rupture.
Exploring the Potential of Long Short‐Term Memory Networks for Improving Understanding of Continental‐ and Regional‐Scale Snowpack Dynamics
Authors: Wang Yuan‐Heng , Gupta Hoshin V. , Zeng Xubin , Niu Guo‐Yue 
Published: March 2022

AbstractAccurate estimation of the spatio‐temporal distribution of snow water equivalent is essential given its global importance for understanding climate dynamics and climate change, and as a source of fresh water. Here, we explore the potential of using the Long Short‐Term Memory (LSTM) network for continental and regional scale modeling of daily snow accumulation and melt dynamics at 4‐km pixel resolution across the conterminous US (CONUS). To reduce training costs (data are available for ∼0.31 million snowy pixels), we combine spatial sampling with stagewise model development, whereby the network is first pretrained across the entire CONUS and then subjected to regional fine‐tuning. Accordingly, model evaluation is focused on out‐of‐sample predictive performance across space (analogous to the prediction in ungauged basins problem). We find that, given identical inputs (precipitation, temperature, and elevation), a single CONUS‐wide LSTM provides significantly better spatio‐temporal generalization than a regionally calibrated version of the physical‐conceptual temperature‐index‐based SNOW17 model. Adding more meteorological information (dew point temperature, vapor pressure deficit, longwave radiation, and shortwave radiation) further improves model performance, while rendering redundant the local information provided by elevation. Overall, the LSTM exhibits better transferability than SNOW17 to locations that were not included in the training data set, reinforcing the advantages of structure learning over parameter learning. Our results suggest that an LSTM‐based approach could be used to develop continental/global‐scale systems for modeling snow dynamics.
Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory
Authors: Jaehne Emily J. , Kent Jessica N. , Antolasic Emily J. , Wright Bradley J. , Spiers Jereme G. , Creutzberg Kerstin C. , De Rosa Federico , Riva Marco A. , Sortwell Caryl E. , Collier Timothy J. , van den Buuse Maarten 
Published: March 2022

AbstractThe common brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with reduced activity-dependent BDNF release and increased risk for anxiety disorders and PTSD. Here we behaviorally phenotyped a novel Val66Met rat model with an equivalent valine to methionine substitution in the rat Bdnf gene (Val68Met). In a three-day fear conditioning protocol of fear learning and extinction, adult rats with the Met/Met genotype demonstrated impaired fear memory compared to Val/Met rats and Val/Val controls, with no genotype differences in fear learning or extinction. This deficit in fear memory occurred irrespective of the sex of the animals and was not seen in adolescence (4 weeks of age). There were no changes in open-field locomotor activity or anxiety measured in the elevated plus maze (EPM) nor in other types of memory measured using the novel-object recognition test or Y-maze. BDNF exon VI expression in the dorsal hippocampus was higher and BDNF protein level in the ventral hippocampus was lower in female Val/Met rats than female Val/Val rats, with no other genotype differences, including in total BDNF, BDNF long, or BDNF IV mRNA. These data suggest a specific role for the BDNF Met/Met genotype in fear memory in rats. Further studies are required to investigate gene–environment interactions in this novel animal model.
ATG7-enhanced impaired autophagy exacerbates acute pancreatitis by promoting regulated necrosis via the miR-30b-5p/CAMKII pathway
Authors: Ji Liang , Wang Zhi-hong , Zhang Yu-hua , Zhou Yi , Tang De-sheng , Yan Chang-sheng , Ma Jia-min , Fang Kun , Gao Lei , Ren Nian-sheng , Cheng Long , Guo Xiao-yu , Sun Bei , Wang Gang 
Published: March 2022

AbstractThe present study was performed to explore whether and how impaired autophagy could modulate calcium/calmodulin-dependent protein kinase II (CAMKII)-regulated necrosis in the pathogenesis of acute pancreatitis (AP). Wistar rats and AR42J cells were used for AP modeling. When indicated, genetic regulation of CAMKII or ATG7 was performed prior to AP induction. AP-related necrotic injury was positively regulated by the incubation level of CAMKII. ATG7 positively modulated the level of CAMKII and necrosis following AP induction, indicating that there might be a connection between impaired autophagy and CAMKII-regulated necrosis in the pathogenesis of AP. microRNA (miR)-30b-5p was predicted and then verified as the upstream regulator of CAMKII mRNA in our setting of AP. Given that the level of miR-30b-5p was negatively correlated with the incubation levels of ATG7 after AP induction, a rescue experiment was performed and indicated that the miR-30b-5p mimic compromised ATG7 overexpression-induced upregulation of CAMKII-regulated necrosis after AP induction. In conclusion, our results indicate that ATG7-enhanced impaired autophagy exacerbates AP by promoting regulated necrosis via the miR-30b-5p/CAMKII pathway.
Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells
Authors: Jo Ara , Bae Jin Hee , Yoon Yu Jeong , Chung Tae Hun , Lee Eun-Woo , Kim Young-Ho , Joh Hea Min , Chung Jin Woong 
Published: March 2022

AbstractCold atmospheric plasma (CAP) that generates reactive oxygen species (ROS) has received considerable scientific attentions as a new type of anticancer. In particular, an indirect treatment method of inducing cancer cell death through plasma-activated medium (PAM), rather than direct plasma treatment has been well established. Although various cell death pathways such as apoptosis, necroptosis, and autophagy have been suggested to be involved in PAM-induced cell death, the involvement of ferroptosis, another type of cell death regulated by lipid ROS is largely unknown. This study reports, that PAM promotes cell death via ferroptosis in human lung cancer cells, and PAM increases intracellular and lipid ROS, thereby resulting in mitochondrial dysfunction. The treatment of cells with N-acetylcysteine, an ROS scavenging agent, or ferrostatin-1, a ferroptosis inhibitor, protects cells against PAM-induced cell death. Interestingly, ferroptosis suppressor protein 1 (FSP1) is downregulated upon PAM treatment. Furthermore, the treatment of cells with iFSP1, an inhibitor of FSP1, further enhances PAM-induced ferroptosis. Finally, this study demonstrates that PAM inhibits tumor growth in a xenograft model with an increase in 4-hydroxynoneal and PTGS2, a byproduct of lipid peroxidation, and a decrease in FSP1 expression. This study will provide new insights into the underlying mechanism and therapeutic strategies of PAM-mediated cancer treatment.
Exploring the ethics of genetic prioritisation for COVID-19 vaccines
Authors: Bruce Jago , Johnson Stephanie B. 
Published: March 2022

AbstractThere is evidence to suggest that host genomic factors may account for disease response variability in COVID-19 infection. In this paper, we consider if and how host genomics should influence decisions about vaccine allocation. Three potential host genetic factors are explored: vulnerability to infection, resistance to infection, and increased infectivity. We argue for the prioritisation of the genetically vulnerable in vaccination schemes, and evaluate the potential for ethical de-prioritisation of individuals with genetic markers for resistance. Lastly, we discuss ethical prioritisation of individuals with genetic markers for increased infectivity (those more likely to spread COVID-19).
Precursors of Majorana modes and their length-dependent energy oscillations probed at both ends of atomic Shiba chains
Authors: Schneider Lucas , Beck Philip , Neuhaus-Steinmetz Jannis , Rózsa Levente , Posske Thore , Wiebe Jens , Wiesendanger Roland 
Published: March 2022

AbstractIsolated Majorana modes (MMs) are highly non-local quantum states with non-Abelian exchange statistics, which localize at the two ends of finite-size 1D topological superconductors of sufficient length. Experimental evidence for MMs is so far based on the detection of several key signatures: for example, a conductance peak pinned to the Fermi energy or an oscillatory peak splitting in short 1D systems when the MMs overlap. However, most of these key signatures were probed only on one of the ends of the 1D system, and firm evidence for an MM requires the simultaneous detection of all the key signatures on both ends. Here we construct short atomic spin chains on a superconductor—also known as Shiba chains—up to a chain length of 45 atoms using tip-assisted atom manipulation in scanning tunnelling microscopy experiments. We observe zero-energy conductance peaks localized at both ends of the chain that simultaneously split off from the Fermi energy in an oscillatory fashion after altering the chain length. By fitting the parameters of a low-energy model to the data, we find that the peaks are consistent with precursors of MMs that evolve into isolated MMs protected by an estimated topological gap of 50 μeV in chains of at least 35 nm length, corresponding to 70 atoms.