bluuebunny/crossref_metadata_2025_split huggingface dataset:
Child emotional and behavioral difficulties and parent stress during COVID-19 lockdown in Sri Lankan families
Authors: Athapathu Ashan , Navaratnam Deluckshi , Doluweera Minul , Liyanage Guwani 
Published: August 2022

IntroductionUnderstanding parents’ and children’s mental health issues would help design population-specific intervention programs. The present study explored parents’ perceived stress and child emotions and behavior during the COVID-19 lockdown among Sri Lankan families.MethodsA cross-sectional survey was conducted among Sri Lankan parents of children aged 11 to 17 years. Validated instruments (Perceived Stress Scale-PSS and Strengths and Difficulties Questionnaire-SDQ) evaluated parental stress, child emotions, and hyperactivity/inattention. Multiple linear regression assessed the predictors of mental health issues, including the interaction between age and gender.ResultsThree hundred fifty-five parents responded to the survey (mothers:76%). One-third of parents experienced difficulties with their children during the pandemic. Emotions and hyperactivity-inattention problems measured via the SDQ scale were high among 38% of children, while the perceived stress was high in 79.2% of parents. Overall, child emotions and hyperactivity-inattention increased with decreasing age, increasing parent stress, having middle-income compared to high-income, and having a family member/close relative tested positive for COVID-19. Hyperactivity-inattention (29.3%) was more than the emotional problems (22%) among children. The emotional problems were reported more with increasing parent stress, while child hyperactivity-inattention alone was reported more with decreasing age, middle-income compared to high-income families, and increasing parent stress. Also, the interaction effect of age and gender indicated that higher age was related to greater parent-reported hyperactivity-inattention problems in males.ConclusionsThe findings highlight how the COVID-19 crisis and social isolation have contributed to increased parental stress and child emotional and hyperactivity-inattention problems. In addition to cautioning the healthcare workers, socio-culturally appropriate preventive and supportive mental health programs may help deal with further waves of COVID-19 or any other adverse circumstances.
Pharmacological treatment for connective tissue disease-associated interstitial lung involvement: Protocol for an overview of systematic reviews and meta-analyses
Authors: Karassa Fotini B. , Bougioukas Konstantinos I. , Pelechas Eleftherios , Skalkou Anastasia , Argyriou Evangelia , Haidich Anna-Bettina 
Published: August 2022

Background
Interstitial lung disease (ILD) is the most important pulmonary manifestation of connective tissue diseases (CTDs) since it is associated with high morbidity and mortality. However, there is uncertainty on what constitutes the optimal treatment options from a variety of competing interventions. The aim of the overview is to summarize existing evidence of the effectiveness and harm of pharmacological therapies for adults with CTD-ILD.

Methods
A literature search will be conducted in MEDLINE, the Cochrane Database of Systematic Reviews, DARE, the Centre for Reviews and Dissemination Health Technology Assessment database, Epistemonikos.org, KSR Evidence, and PROSPERO. We will search for systematic reviews with or without meta-analysis that examine pharmacological treatment for CTD-ILD. Updated supplemental search will also be undertaken to identify additional randomized controlled trials. The primary outcomes will be changes in lung function measures and adverse events. The methodological quality of the included reviews will be assessed using the AMSTAR 2 tool. The overall quality of the evidence will be evaluated using the GRADE rating. Summarized outcome data extracted from systematic reviews will be described in narrative form or in tables. For each meta-analysis we will estimate the summary effect size by use of random-effects and fixed-effects models with 95% confidence intervals, the between-study heterogeneity expressed by I², and the 95% prediction interval. If feasible, given sufficient data, network meta-analysis will be conducted to combine direct and indirect evidence of class and agent comparisons.

Discussion
While many factors are crucial in selecting an appropriate treatment for patients with CTD-ILD, evidence for the efficacy and safety of a drug is essential in guiding this decision. Thus, this overview will aid clinicians in balancing the risks versus benefits of the available therapies by providing high-quality evidence to support informed decision-making and may contribute to future guideline development.

Systematic review registration
MedRxiv: DOI 10.1101/2022.01.25.22269807
PROSPERO: CRD42022303180
Bone, Brain, Heart study protocol: A resilient nested, tripartite prospective cohort study of the role of estrogen depletion on HIV pathology
Authors: Mehta C. Christina , Hagen Kimberly S. , Rubtsova Anna A. , Lahiri Cecile D. , Michopoulos Vasiliki , Moran Caitlin A. , Haddad Lisa B. , Titanji Kehmia , Collins Lauren F. , Quyyumi Arshed A. , Neigh Gretchen , Shaw Leslee J. , Weitzmann M. Neale , Waller Lance , Ofotokun Ighovwerha 
Published: August 2022

Purpose
We describe the rationale for and design of an innovative, nested, tripartite prospective observational cohort study examining whether relative estrogen insufficiency-induced inflammation amplifies HIV-induced inflammation to cause end organ damage and worsen age-related co-morbidities affecting the neuro-hypothalamic-pituitary-adrenal axis (Brain), skeletal (Bone), and cardiovascular (Heart/vessels) organ systems (BBH Study).

Methods
The BBH parent study is the Multicenter AIDS Cohort/Women’s Interagency HIV Study Combined Cohort Study (MWCCS) with participants drawn from the Atlanta MWCCS site. BBH will enroll a single cohort of n = 120 women living with HIV and n = 60 HIV-negative women, equally distributed by menopausal status. The innovative multipart nested study design of BBH, which draws on data collected by the parent study, efficiently leverages resources for maximum research impact and requires extensive oversight and management in addition to careful implementation. The presence of strong infrastructure minimized BBH study disruptions due to changes in the parent study and the COVID-19 pandemic.

Conclusion
BBH is poised to provide insight into sex and HIV associations with the neuro-hypothalamic-pituitary-adrenal axis, skeletal, and cardiovascular systems despite several major, unexpected challenges.
Study on physical properties of Al2O3-based slags used for the self-propagating high-temperature synthesis (SHS) – metallurgy method
Authors: Shi Guan-yong , Zhang Ting-an , Niu Li-ping , Dou Zhi-he 
Published: August 2022

Abstract
The Al2O3-based slags are playing important roles in the preparation of Cu–Cr alloy through self-propagating high-temperature synthesis (SHS) – Metallurgy method. However, the current research on Al2O3-based slag is mainly concentrated on steel metallurgical slag and electroslag remelting slag, and the research on aluminum thermal reduction slag with high content of Al2O3 is still insufficient. Therefore, systematic studies of the physical properties of slag with high aluminum content were carried out in the present work, and the influence of CaF2, CaO, MgO, SiO2, and Na3AlF6 on viscosities, liquidus temperatures, densities, and surface tensions of high Al2O3 content slags was measured and analyzed. The results indicated that CaO and CaF2 have positive effects on the physical properties of Al2O3-based slags, MgO has positive effects when its content is not over 3%, and SiO2 and Na3AlF6 have negative impacts. CaO, CaF2, and MgO (not over 3%) could be used as additives to improve the metallurgical performance of Al2O3-based slags in aluminothermic reduction–slag refining method.
Standard deviation estimation from sums of unequal size samples
Authors: Casquilho Miguel , Buescu Jorge 
Published: August 2022

Abstract
In numerous industrial and related activities, the sums of the values of, frequently, unequal size samples are systematically recorded, for several purposes such as legal or quality control reasons. For the typical case where the individual values are not or no longer known, we address the point estimation, with confidence intervals, of the standard deviation (and mean) of the individual items, from those sums alone.
The estimation may be useful also to corroborate estimates from previous statistical process control. An everyday case of a sum is the total weight of a set of items, such as a load of bags on a truck, which is used illustratively.
For the parameters mean and standard deviation of the distribution, assumed Gaussian, we derive point estimates, which lead to weighted statistics, and we derive confidence intervals. For the latter, starting with a tentative reduction to equal size samples, we arrive at a solid conjecture for the mean, and a proposal for the standard deviation. All results are verifiable by direct computation or by simulation in a general and effective way. These computations can be run on public web pages of ours, namely for possible industrial use.
Not Just Many Worlds but Many Universes? A Problem for the Many Worlds View of Quantum Mechanics
Authors: Baumann Peter 
Published: August 2022

Abstract
The many-worlds view is one of the most discussed “interpretations” of quantum mechanics. As is well known, this view has some very controversial and much discussed aspects. This paper focuses on one particular problem arising from the combination of quantum mechanics with Special Relativity. It turns out that the ontology of the many-worlds view – the account of what there is and what branches of the universe exist – is relative to inertial frames. If one wants to avoid relativizing ontology, one has to argue either that there is an additional source of branching due to Special Relativity and thus additional branches or worlds. Or one has to argue that there are not only many worlds but also many universes (sets of worlds or world-branches); there is thus not only one tree of many world-branches but many frame-specific trees, a “forest” of many world-trees. The main problem here is how one can understand all or any of this.
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization
Authors: Chen Dawei , Nemazanyy Ivan , Peulen Olivier , Shostak Kateryna , Xu Xinyi , Tang Seng Chuan , Wathieu Caroline , Turchetto Silvia , Tielens Sylvia , Nguyen Laurent , Close Pierre , Desmet Christophe , Klein Sebastian , Florin Alexandra , Büttner Reinhard , Petrellis Georgios , Dewals Benjamin , Chariot Alain 
Published: August 2022

AbstractMacrophage polarization is a process whereby macrophages acquire distinct effector states (M1 or M2) to carry out multiple and sometimes opposite functions. We show here that translational reprogramming occurs during macrophage polarization and that this relies on the Elongator complex subunit Elp3, an enzyme that modifies the wobble uridine base U34 in cytosolic tRNAs. Elp3 expression is downregulated by classical M1‐activating signals in myeloid cells, where it limits the production of pro‐inflammatory cytokines via FoxO1 phosphorylation, and attenuates experimental colitis in mice. In contrast, alternative M2‐activating signals upregulate Elp3 expression through a PI3K‐ and STAT6‐dependent signaling pathway. The metabolic reprogramming linked to M2 macrophage polarization relies on Elp3 and the translation of multiple candidates, including the mitochondrial ribosome large subunit proteins Mrpl3, Mrpl13, and Mrpl47. By promoting translation of its activator Ric8b in a codon‐dependent manner, Elp3 also regulates mTORC2 activation. Elp3 expression in myeloid cells further promotes Wnt‐driven tumor initiation in the intestine by maintaining a pool of tumor‐associated macrophages exhibiting M2 features. Collectively, our data establish a functional link between tRNA modifications, mTORC2 activation, and macrophage polarization.
Enteral Low-Dose Vitamin A Supplementation in Preterm or Low Birth Weight Infants to Prevent Morbidity and Mortality: a Systematic Review and Meta-analysis
Authors: Manapurath Rukman M. , Kumar Mohan , Pathak Barsha Gadapani , Chowdhury Ranadip , Sinha Bireshwar , Choudhary Tarun , Chandola Naro , Mazumdar Sarmila , Taneja Sunita , Bhandari Nita , Upadhyay Ravi Prakash 
Published: August 2022

OBJECTIVES
To assess effects of enteral “low” dose (daily doses of ≤10 000 international unit) vitamin A supplementation compared with no vitamin A supplementation in human milk-fed preterm and low birth weight (LBW) infants.

DATA SOURCES
Cochrane Central Register of Controlled Trials; Medline, Embase, Scopus, Web of Science, CINAHL from inception to 16 March 2021.

STUDY SELECTION
Randomized trials were screened. Primary outcomes were mortality, morbidity, growth, neurodevelopment. Secondary outcomes were feed intolerance and duration of hospitalization. We also assessed the dose and timing of vitamin A supplementation. Data were extracted and pooled with fixed and random-effects models.

RESULTS
Four trials including 800 very LBW &lt;1.5 kg or &lt;32 weeks’ gestation infants were found. At latest follow-up, we found little or no effect on: mortality, sepsis, bronchopulmonary dysplasia, retinopathy of prematurity, duration of hospitalisation. However, we found a increased level of serum retinol mean difference of 4.7 μg/ml (95% CI 1.2 to 8.2, I2 =0.00%, one trial, 36 participants,). Evidence ranged from very low to moderate certainty. There were no outcomes reported for length, head circumference or neurodevelopment.

LIMITATIONS
Heterogeneity and small sample size in the included studies.

CONCLUSIONS
Low-dose vitamin A increased serum retinol concentration among very LBW and very preterm infants but had no effect on other outcomes. More trials are needed to assess effects on clinical outcomes and to assess effects in infants 1.5 to 2.4 kg or 32 to 26 weeks’ gestation.
Cáncer de cérvix en Costa Rica, barreras según las dimensiones de la asistencia sanitaria: una revisión sistemática cualitativa
Authors: Rivera Chavarría Ana Leonor , Calderón- Céspedes Alejandro 
Published: August 2022

Introducción: de las muertes de mujeres en el mundo por algún tipo de cáncer, el de cérvix es responsable del 7 % del total. En Costa Rica, cada año se diagnostican en promedio 320 casos y fallecen 140 mujeres por esta enfermedad. Objetivo: identificar barreras para el diagnóstico y el tratamiento del cáncer cérvico-uterino, según la disponibilidad de la asistencia sanitaria en Costa Rica. Metodología: se realizó una revisión sistemática cualitativa de literatura entre mayo y setiembre de 2021. Se examinaron estudios publicados de enero de 2010 a junio de 2021 con diseño cuantitativo, cualitativo o ambos, de fuente primaria o secundaria, que identificaran limitaciones para acceder a la atención según población general, usuarios o personal de salud en Costa Rica. Resultados: se seleccionaron 9 artículos científicos. Se identificaron 5 dimensiones del modelo de Tanahashi y 26 barreras correspondientes a cada una: 12 de disponibilidad, 5 de accesibilidad, 3 de aceptabilidad, 2 de contacto con el servicio y 4 de cobertura efectiva. Conclusiones: las dificultades en torno al servicio médico son múltiples y están presentes en todas las dimensiones descritas en el modelo de Tanahashi. Los hallazgos de este estudio destacan la importancia de abordarlas, lo cual, en algunas podría ser complejo. No obstante, otras variables son relativamente simples de solucionar a nivel de sistema, política o práctica.
Eksplorasi dan karakterisasi keragaman plasma nutfah tanaman padi (Oryza sativa L.) di pulau Belitung
Authors: Kencana Yuditia Arta , Mustikarini Eries Dyah , Lestari Tri 
Published: July 2022

Banyak sumber daya genetik penting yang masih belum teridentifikasi di Pulau Belitung salah satunya adalah tanaman padi. Kegiatan eksplorasi dan identifikasi menjadi langkah yang tepat untuk mendapatkan jenis tanaman padi baru pada kegiatan pemuliaan tanaman. Tujuan penelitian ini adalah melakukan eksplorasi, karakterisasi, dan menentukan hubungan kekerabatan dan variabilitas padi di Pulau Belitung. Penelitian dilaksanakan dari bulan Desember 2020 hingga Mei 2021. Penelitian menggunakan metode eksplorasi dengan teknik pengambilan sampel secara purposive sampling. Karakter yang diidentifikasi terdiri dari karakter kualitatif dan karakter kuantitatif. Analisis kekerabatan menggunakan program NTSYS. Hasil penelitian didapatkan lima aksesi yaitu Rembiak, Siam, Cerai Merah, Ketan dan Merawang. Hasil uji beda nyata terkecil (BNT) menunjukkan aksesi padi lokal Belitung memiliki perbedaan yang nyata pada karakter umur panen (α 5%). Hasil analisis hubungan kekerabatan pada karakter kualitatif terdapat 2 grup dengan koefisien 0,64 atau 64%, kuantitatif terdapat 4 grup dengan koefisien 0,28 atau 28% dan gabungan dari karakter kualitatif dan kuantitatif terdapat 4 grup dengan koefisien 0,33 atau 33%. Aksesi padi yang diperoleh terdapat variabilitas genetik luas yaitu pada karakter jumlah biji total serta variabilitas fenotip yang luas yaitu pada tinggi tanaman, umur panen dan berat 1000 benih.ABSTRACTMany important genetic resources have not identified yet on the Belitung Island, one of which is rice plant. Exploration and identification activities are the right steps to get a new type of rice plant in plant breeding activities. The objectives of research were to explore, characterize, and determine the relationship and variability of rice on Belitung Island. The experiment was conducted from December 2020 to May 2021. Research used exploratory methods with purposive sampling technique.The identified character consisted of qualitative and quantitative characters. Kinship analysis using the NTSYS program. The results of the study obtained five accessions namely Rembiak, Siam, Cerai Merah, Ketan and Merawang. Least Significance Different (LSD) results showed that local rice accession had a noticeable difference in the character of the harvest age (α 5%)." The results of the analysis of relationships in qualitative character there were 2 groups with coefficients of 0.64 or 64%, quantitative there were 4 grup with coefficients of 0.28 or 28% and a combination of qualitative and quantitative characters there were 4 groups with coefficients of 0.33 or 33%. Rice accession obtained contained extensive genetic variability in the character of the total number of seeds as well as wide phenotype variability on the plant height, harvest age and weight of 1000 seeds.
Bioassay of phosphorus solubilizing isolates for enhance P solubility and growth of rice (Oryza sativa L.)
Authors: Fitriatin Betty Natalie , Manurung Dahlia Florencia , Setiawati Mieke Rochimi 
Published: July 2022

Fosfat merupakan salah satu unsur yang berperan penting bagi pertumbuhan tanaman dan kesuburan tanah. Namun, ketersediaan unsur P terlarut yang dapat diserap oleh tanaman sangat kecil karena berikatan dengan kation yang berada di dalam tanah. Salah satu upaya dalam meningkatkan P tersedia dalam tanah adalah dengan pemanfaatan agen hayati Bakteri Pelarut Fosfat (BPF). Penelitian ini bertujuan untuk menguji isolat BPF yang dapat meningkatkan kelarutan P dan pertumbuhan padi pada uji hayati. Percobaan ini dilaksanakan di Rumah Kaca Departemen Ilmu Tanah dan Sumber Daya Lahan, Fakultas Pertanian, Universitas Padjadjaran. Rancangan percobaan yang digunakan adalah Rancangan Acak Kelompok (RAK) dengan 6 perlakuan dan 5 ulangan. Masing-masing perlakuan jenis bakteri adalah kontrol, Bacillus substilis, B. megatherium, Pseudomonas mallei, Burkholderia sp., dan isolat campuran. Hasil percobaan menunjukkan isolat BPF yang diuji memiliki kemampuan yang bervariasi dalam meningkatkan enzim fosfatase, kelarutan P, dan pertumbuhan padi pada uji hayati. Lebih lanjut, perlakuan BPF campuran memberikan pengaruh lebih baik terhadap aktivitas fosfatase, P terlarut dan pertumbuhan padi dibandingkan isolat tunggal.ABSTRACTPhosphorus is an element that important for soil fertility and plant growth. However, the phosphate nutrient can be uptaken by plants only in a small amount because it binds to cations in the soil. The effort for enhancing the soil P availabilty is by the phosphorus solubilizing bacteria (PSB). This study aimed to test PSB isolates for increasing P solubility and rice growth using bioassay. The experiment conducted at the greenhouse in Jatinangor District, Sumedang Regency, West Java with Randomized Block Design (RBD) for PSB isolates with five replications. Each type of bacteria treatment was control, Bacillus substilis, B. megatherium, Pseudomonas mallei, Burkholderia sp., and mixed isolates. The results showed that the P solubilizing isolates had various abilities to enhance phosphatase, P solubility, and rice growth using bioassay. Furthermore, the mixed PSB isolates had a better effect on phosphatase activity, dissolved P and rice growth than single isolates.
Perbaikan fisik tanah pasca galian batuan dan pertumbuhan cabai rawit dengan pemberian bahan organik dan mikroorganisme tanah
Authors: Pangaribuan Nurmala , Hidayat Cecep , Rachmawati Yati Setiati 
Published: July 2022

Bahan organik dan mikroorganisme diperlukan untuk memperbaiki sifat fisik tanah pasca galian batuan agar dapat digunakan untuk budidaya tanaman. Penelitian ini bertujuan untuk mengetahui pengaruh aplikasi bahan organik dan mikroorganisme tanah terhadap perbaikan fisik tanah pasca galian batuan dan pertumbuhan cabai rawit. Penelitian dilaksanakan di Cibiru Bandung, Jawa Barat dengan titik ordinat -6.92049471880716, 107.716127309820, dari bulan Juni sampai Oktober 2020, menggunakan Rancangan Acak Kelompok (RAK) Faktorial dua faktor dan diulang tiga kali. Faktor pertama yaitu bahan organik: b0 : kontrol (tanpa pemberian bahan organik), b1: kompos Paitan 15 t ha-1, b2: kompos eceng gondok 15 t ha-1, b3: abu cangkang sawit 15 t ha-1. Faktor kedua : mikroba: mo: kontrol (tanpa pemberian mikroba), m1 : Inokulum campuran Fungi Mikoriza Asburkular (FMA) 10 g polibag-1, m2 :Inokulum campuran BPF (Bakteri Pelarut Fosfat) 10 ml polibag-1, m3 : campuran FMA dan BPF. Hasil penelitian menunjukkan eceng gondok 15 t ha-1 yang diberikan bersamaan dengan FMA atau BPF menaikan kelembaban tanah. Aplikasi bahan organik dan mikroba menurunkan agregat stabil tahan air. Eceng gondok dan BPF masing-masing menurunkan suhu tanah. Aplikasi bahan organik dan mikroorganisme belum berpengaruh dalam peningkatan pertumbuhan tanaman cabai rawit, namun berpengaruh terhadap fisik tanah tanah pasca galian batuan.ABSTRACTOrganic matters and microorganisms are needed to improve the physical properties of the post-mine sand pits soil so that it can be used for plant cultivation. The purpose of this study was to know the influence of organic matters and soil microorganism application on post-mine sand pits soil improvement and chili pepper growth. This study was conducted in Cibiru Bandung (-6.92049471880716, 107.716127309820), from June to October 2020, using Block Randomized Factorial Design two factors and repeated three times. The first factor was organic matters: b0 : control, b1: compost Titonia 15 t ha-1, b2: compost Hyacinth 15 t ha-1, b3: palm shell ash 15 tha-1. The second factor: microbes: m0: control, m1: mix inoculum AMF 10 g polybag-1, m2 : mix inoculum PSB 10 ml polybag-1 , m3 : mixture of AMF and PSB. The results showed that hyacinth 15 t ha-1 given with FMA or PSB increased soil moisture. The application of organic matters and microbes decreased water stable aggregates. Hyacinth and PSB lower the temperature of the soil. The application of organic matters and microorganisms has not had an effect in increasing the growth of chili pepper plants but influences the physical properties of the post-mine sand pit soil.