bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neighbor Coverage and Bandwidth Aware Multiple Disjoint Path Discovery in Wireless Mesh Networks
Authors: S ANITA C , R SASIKUMAR 
Published: April 2022

Abstract
With the ease of appending new nodes without re-installing the whole network, the Internet of Things (IoT) builds several smart applications on Wireless Mesh Network (WMN). One of the important aspects of integrating WMN and smart IoT applications is to provide an energy-efficient and reliable routing protocol. Seeking the communication route that delivers the high-quality stream quickly over WMN is an important issue, but the maximum utilization of a single high-quality path leads to poor throughput and large communication delay, including route discovery and data forwarding delay. The broadcasting mechanism creates redundant transmissions of control packets into the network and reinitializes the blind route discovery process due to link disconnections leading to network resource constraints and high delay during the route discovery process. Moreover, the congestion in the communication route incurs data transmission latency. This paper proposes the Multiple Disjoint Path Determination (MDPD) mechanism based on-demand routing in WMN to formulate the path discovery and data transmission latency. Reducing the neighbor list into the uncommon neighbor set reduces the unnecessary latency in route discovery, and deriving high capacity multiple disjoint communication routes reduce the communication delay in the proposed work. The proposed work employs the queue dynamics in queuing delay, which mainly provides adaptability to the dynamics in network capacity and efficient diversity paths to the gateway node to infer the available bandwidth and optimize the network traffic. To fully utilize the advantage of heterogeneous routers, it disables the flooding of control packets across the stable mesh routers, excluding the initial route discovery process, because it enables the available route storage system in each mesh router. Hence, the proposed work efficiently supports wireless broadband internet access with reduced delay and control overhead. The simulation results demonstrate the fast detection of the multiple disjoint routes and data traffic optimization over the discovered disjoint routes in the proposed MDPD mechanism over WMN.
Antibiotic Prescribing Pattern for Upper Respiratory Tract Infection among Outpatients in Sana’a – Yemen
Authors: Ibrahim Doa'a Anwar , Halboup Abdulsalam M. , Al-Dhubaie Shatha , Hayal Noor , Shaaban Aisha , Alhazwarah Hajer , Al-thalje Soha ,   Afra Alsabri1, Areqi Abdullah Ahmed 
Published: April 2022

Abstract

Background
inappropriate prescribing of antibiotics is frequently encountered in upper respiratory tract infections, it considers the leading cause of misuse of antibiotics, which leads to unnecessary adverse effects and antibiotic resistance. Data about antibiotics prescription in developing countries are lacking. This study assessed antibiotic prescription in Sana’a city in the treatment of upper respiratory tract infections.
Objective
This study aimed to describe the current pattern of antibiotic use for the treatment of URTI in outpatient settings in Sana`a – Yemen by evaluating the adequacy and appropriateness of antibiotic prescribing corresponding to treatment guidelines.
Methods
A prospective, descriptive, cross-sectional study was conducted on patients diagnosed with upper respiratory tract infections at outpatient settings of different private and public hospitals in Sana’a–Yemen in September 2019 using a validated questionnaire. Diagnosis was classified as appropriate or inappropriate based on the most likely pathogen that may warrant antibiotic use. Chi-square test and logistic regression were the analytical methods used in this study.
Results
A total of 485 patients were included in this study. Of these, 462 (95.3%) were prescribed antibiotics. The majority of them (78.35%, N = 362) received antibiotics appropriately. However, (21.64%, N = 100) received antibiotics for inappropriate indication. High prescribing rates were observed in patients with pharyngotonsillitis ( 44.12%, N = 214 ) followed by acute otitis media ( 14.23%, N = 69) and bronchitis (11.55%, N = 56 ).The most common antibiotics classes prescribed were penicillin including amoxicillin-clavulanic acid (47.6% of patients, 19.09% inappropriate ), follow by macrolide ( 27.9% of patients, 29.46% inappropriate), cephalosporin (14.5% of patients, 3% inappropriate) and fluoroquinolone (9.3% of patients, 34.88% inappropriate ).Conclusion: Antibiotic prescribing for upper respiratory tract infections in some health care centers in Sana`a – Yemen was very high with a considerable proportion of inappropriate antibiotics prescriptions. patient's characteristics have an impact on physicians' prescribing patterns of antibiotics. we recommend further studies of this important issue, to find out the reasons of overusing antibiotics by physicians in this illness.
Validation of Medical Service Insurance Claims as a Surrogate for Ascertaining Vitiligo Cases
Authors: Bell Madelaine , Lui Harvey , Lee Tim , Kalia Sunil 
Published: April 2022

Abstract
Background: The epidemiology of vitiligo, especially its disease burden on the healthcare system, can be assessed indirectly by analyzing health insurance claims data. Validating this approach is integral to ensuring accurate case identification and cohort characterization.Objectives: The primary aim of this study was to develop and validate an indirect measure of vitiligo ascertainment using health insurance claims data. These data were used secondarily to identify demographic characteristics, body site involvement, vitiligo subtypes, disease associations, and treatments. Methods: This study assessed the validity of identifying vitiligo from billing claims within a Canadian provincial universal health insurance program, versus vitiligo cases accrued from direct medical chart reviews. Claims-based algorithms combining ICD-9-CM diagnostic code 709 with treatment-specific data were derived and tested to identify vitiligo patients. This was compared against cases arising from the manual review of medical records of 606 patient with a diagnostic code for “dyschromia” (ICD-9-CM diagnostic code 709) from January 1 to December 31, 2016.Results: Based on the chart reviews, 204 (33.7%) patients were confirmed to have vitiligo. 42 separate claims-based algorithms combining ICD-9-CM diagnostic code 709 with treatment data specific to vitiligo were modelled and individually tested to evaluate their accuracy for vitiligo ascertainment. One algorithm achieved a sensitivity, specificity, PPV and NPV of 86.8% (95% CI 82.1-91.4), 92.5% (95% CI 90.0-95.1), 85.5% (95% CI 80.7-90.3), and 93.2% (95% CI 90.8-95.7), respectively. There was a 2.2 female to male ratio. The most common medical treatments were tacrolimus (74.5%) and topical corticosteroids (54.3%). Hypertension (24.2%) and hypothyroidism (19.6%) were the predominant co-morbidities associated with vitiligo. Conclusions: Health insurance claims data can be used to indirectly ascertain vitiligo for epidemiologic purposes with relatively high diagnostic performance between 85.5-93.2%.
A POPULARIZAÇÃO DO CONHECIMENTO COMO FORMA DE INTERAÇÃO ENTRE A ACADEMIA E A SOCIEDADE
Authors: Speguen de Quadros Piccoli Marcia , Panizzon Mateus 
Published: April 2022

A popularização do conhecimento, de acordo com o portal do Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq é uma ação que divulga os resultados científicos e tecnológicos das pesquisas para além da academia, alcançando a sociedade por meio da disseminação de informações para um público amplo, com linguagem apropriada e direcionada para esse fim. Ao olhar para essa prática no âmbito das Instituições Comunitárias de Educação Superior (ICES), observa-se que este pode ser um caminho para a interlocução entre a academia e a sociedade, tendo em vista que a busca dessa aproximação tem sido um fato presente no planejamento institucional das ICES. Com isso, para observar a popularização do conhecimento e dos resultados das pesquisas científicas numa universidade comunitária, o percurso metodológico considerou as respostas apresentadas por pesquisadores para um questionário estruturado sobre o tema. Os dados foram explorados com base na análise textual discursiva, seguindo os preceitos de Bacellar (2005) e de Moraes e Galiazzi (2011). Ademais, foram estabelecidas pelos autores do artigo as categorias para interpretação do questionário, identificadas como: domínio do conceito sobre popularização do conhecimento; o interesse pelo tema; as práticas de popularização do conhecimento; os desafios existentes e o entendimento sobre os resultados que essa ação pode proporcionar. Essas categorias são colocadas em relação a três dimensões de análise para instituições de educação superior, propostas por McCowan (2018): valor, função e interação. A partir dessas interfaces, é proposto o Sistema para a Popularização do Conhecimento Científico das Universidades para a Sociedade.
Nanoscale Treatment of Intervertebral Disc Degeneration: Mesenchymal
Stem Cell Exosome Transplantation
Authors: Hu Yi-cun , Zhang Xiao-bo , Lin Mao-Qiang , Zhou Hai-Yu , Cong Meng-xue , Chen Xiang-yi , Zhang Rui-hao , Yu De-chen , Gao Xi-dan , Guo Tao-wen 
Published: April 2022

Abstract:
A common surgical disease, intervertebral disc degeneration (IVDD), is increasing at an alarming
rate in younger individuals. Repairing damaged intervertebral discs (IVDs) and promoting IVD tissue
regeneration at the molecular level are important research goals. Exosomes are extracellular vesicles
(EVs) secreted by cells and can be derived from most body fluids. Mesenchymal stem cell-derived exosomes
(MSC-exos) have characteristics similar to those of the parental MSCs. These EVs can shuttle
various macromolecular substances, such as proteins, messenger RNAs (mRNAs), and microRNAs
(miRNAs) and regulate the activity of recipient cells through intercellular communication. Reducing inflammation
and apoptosis can significantly promote IVD regeneration to facilitate the repair of the IVD.
Compared with MSCs, exosomes are more convenient to store and transport, and the use of exosomes can
prevent the risk of rejection with cell transplantation. Furthermore, MSC-exo-mediated treatment may be
safer and more effective than MSC transplantation. In this review, we summarize the use of bone marrow
mesenchymal stem cells (BMSCs), adipose-derived mesenchymal stem cells (AMSCs), nucleus pulposus
mesenchymal stem cells (NPMSCs), and stem cells from other sources for tissue engineering and use in
IVDD. Here, we aim to describe the role of exosomes in inhibiting IVDD, their potential therapeutic effects,
the results of the most recent research, and their clinical application prospects to provide an overview
for researchers seeking to explore new treatment strategies and improve the efficacy of IVDD treatment.
Advances in the Management of Dentin Hypersensitivity: An Updated Review
Authors: Dam Van Viet , Nguyen The Hanh , Trinh Hai Anh , Dung Da Thi , Hai Trinh Dinh 
Published: April 2022

Background:Objective: The objective of this narrative review is to present an overview of dentin hypersensitivity and of the prevalence, etiology, mechanism, diagnosis, and clinical management.Methods:Available articles (research, reviews, commentary, views, or editorial) on hypersensitivity were searched and reviewed from January 1990 till March 2021 in Pubmed, Scopus, Google Scholar, and Science Direct. Relevant studies in English were included and critically analyzed in this article.Results:Dentin hypersensitivity causes severe pain. The most effective and least invasive remedy is using desensitizing toothpaste. In addition, based on the dentin hypersensitivity severity, management can be done professionally in-office and through self-applied at-home treatments.Conclusion:Although dentin hypersensitivity causes severe pain, it can be treated using a proper remedy. Correct diagnosis helps in the proper management of dentine hypersensitivity.Management of dentinal hypersensitivity should be done with more conservative strategies first, followed by irreversible dental interventions.
Selenium and Platinum Compounds in Cancer Therapy: Potentiality of their Progeny as Future Chemotherapeutics
Authors: Priyadarsini Karirayani Indira , Jain Vimal Kumar 
Published: April 2022

Abstract:Compounds based on two different elements, selenium and platinum, have been attracting researchers to deploy them in chemotherapy of human cancers. Selenium, as a micronutrient plays many important roles in human biology. Different research groups have been developing both inorganic and organoselenium compounds for potential use for treatment of diseases including cancer. New synthetic designs are emerging to develop selenium compounds either as chemo-preventive or chemotherapeutic agents. Platinum is another important element in cancer therapy. Platinum-based drugs are the first line of treatment for many cancers. Attracted by the fact that chalcogens are excellent ligands for platinum, new ideas are emerging to develop selenium-bound platinum compounds as cancer therapeutics. In this direction, our group has made a beginning to develop stable seleno-platinum compounds to explore their anti-cancer potentials.
The Prediction of Preterm Birth Using Time-Series Technology-Based Machine Learning: Retrospective Cohort Study
Authors: Zhang Yichao , Lu Sha , Wu Yina , Hu Wensheng , Yuan Zhenming 
Published: April 2022

Background
Globally, the preterm birth rate has tended to increase over time. Ultrasonography cervical-length assessment is considered to be the most effective screening method for preterm birth, but routine, universal cervical-length screening remains controversial because of its cost.

Objective
We used obstetric data to analyze and assess the risk of preterm birth. A machine learning model based on time-series technology was used to analyze regular, repeated obstetric examination records during pregnancy to improve the performance of the preterm birth screening model.

Methods
This study attempts to use continuous electronic medical record (EMR) data from pregnant women to construct a preterm birth prediction classifier based on long short-term memory (LSTM) networks. Clinical data were collected from 5187 pregnant Chinese women who gave birth with natural vaginal delivery. The data included more than 25,000 obstetric EMRs from the early trimester to 28 weeks of gestation. The area under the curve (AUC), accuracy, sensitivity, and specificity were used to assess the performance of the prediction model.

Results
Compared with a traditional cross-sectional study, the LSTM model in this time-series study had better overall prediction ability and a lower misdiagnosis rate at the same detection rate. Accuracy was 0.739, sensitivity was 0.407, specificity was 0.982, and the AUC was 0.651. Important-feature identification indicated that blood pressure, blood glucose, lipids, uric acid, and other metabolic factors were important factors related to preterm birth.

Conclusions
The results of this study will be helpful to the formulation of guidelines for the prevention and treatment of preterm birth, and will help clinicians make correct decisions during obstetric examinations. The time-series model has advantages for preterm birth prediction.
Kualitas Hidup dan Biaya Sakit Pasien Dengue di Rumah Sakit PKU Muhammadiyah Bantul Yogyakarta
Authors: Ratnawiningsih Herjanti , Perwitasari Dyah Aryani , Supadmi Woro , Faridah Imaniar Noor 
Published: April 2022

Jumlah kasus penyakit infeksi dengue pada tahun 2019 di Kabupaten Bantul mencapai 1.424 orang. Berdasarkan manifestasi klinis dengue terbagi menjadi dengue fever (DF), dengue haemorrhagic fever (DHF) dan dengue shock syndrome (DSS), dapat memberikan dampak pada kualitas hidup dan biaya sakit. Tujuan penelitian untuk mengetahui kualitas hidup dan biaya sakit pasien dengue selama menjalani rawat inap. Penelitian ini dilakukan dengan rancangan cross-sectional di Rumah Sakit PKU Muhammadiyah Bantul Yogyakarta periode Februari - Juli 2021. Kualitas hidup dinilai menggunakan instrumen EQ-5D-5L untuk pasien dewasa dan EQ-5D-Y untuk pasien anak, sedangkan biaya sakit diperoleh dari bagian keuangan rumah sakit yaitu biaya medis langsung. Sebanyak 40 pasien rawat inap dengan dengue berjenis kelamin laki-laki (60%), usia 4-20 tahun (75%) dan menggunakan asuransi BPJS (82,5%). Kualitas hidup pasien menunjukkan bahwa sebesar 80% pasien DF sedikit bermasalah pada dimensi perawatan diri, sebesar 69% dan 100% pada pasien DHF dan DSS sedikit bermasalah pada dimensi rasa sakit/ketidaknyamanan. Rata-rata biaya sakit pada pasien DF, DHF dan DSS masing-masing sebesar Rp 3.192.725 , Rp 2.872.517 dan Rp 5.090.190. Infeksi dengue memberikan dampak pada kualitas hidup pasien dengue. Rata-rata biaya sakit tertinggi pada pasien dengan DSS.
Evaluasi Penggunaan Obat Berdasarkan Indikator Kinerja Pelayanan Kefarmasian Pada Puskesmas Wilayah Kota Kupang
Authors: Fudholi Achmad , Andayani Tri Murti , Satibi Satibi , Gilarsih Natalia 
Published: April 2022

Berangkat dari permasalahan belum optimalnya penerapan penggunaan obat secara rasional pada pelayanan kesehatan di Indonesia maka telah dikembangkan indikator khusus yang menjadi dasar penilaian kinerja pelayanan kefarmasian di puskesmas. Penelitian ini bertujuan untuk mengevaluasi penggunaan obat di puskesmas wilayah Kota Kupang berdasarkan indikator hasil metode Delphi yang dikembangkan oleh Satibi dkk. Jenis penelitian yang digunakan adalah deskriptif dengan pendekatan kuantitatif, menggunakan data retrospektif tahun 2018 dan melalui observasi langsung. Pemilihan sampel puskesmas dilakukan dengan purposive sampling. Data hasil penelitian berupa data kuantitatif, dianalisis secara deskriptif dan 6 indikator diantaranya dibandingkan dengan standar Kemenkes RI dan WHO. Hasil penelitian menunjukkan bahwa penggunaan obat belum rasional sesuai standar WHO ataupun Kemenkes RI pada indikator item per resep, penggunaan obat generik dan pemberian oralit dan zink sedangkan indikator antibiotik pada diare non spesifik, antibiotik pada ISPA non pneumonia dan penggunaan injeksi pada myalgia telah memenuhi standar yang ada. Indikator biaya obat per kunjungan resep sebesar Rp.9.394 ± Rp.1.341 digunakan sebagai parameter dalam penetapan alokasi dana pengadaan obat tahun berikutnya dan indikator kejadian medication error tidak dapat dievaluasi karena tidak tersedianya dokumentasi tersebut. Kesimpulan menunjukkan puskesmas wilayah Kota Kupang masih mengalami masalah dalam jumlah item obat per resep, penggunaan obat generik, pemberian oralit dan zink dan pendokumentasian kejadian medication error. Hal ini menunjukkan adanya kebutuhan untuk meningkatkan pengetahuan tenaga kefarmasian yang dapat mendukung penggunaan obat rasional di puskesmas.
Pengaruh Konseling Apoteker Terhadap Outcome Anemia Pada Siswi SMA Yang Menerima Program Suplementasi Zat Besi
Authors: Novrita Sisri , Puspitasari Ika , Yasin Nanang Munif , Wardhani Chrisna 
Published: April 2022

Keberhasilan program pencegahan dan penanggulangan anemia defesiensi besi pada remaja putri tergantung dari tingkat kepatuhan individual terhadap pengobatan. Ketidakpatuhan remaja putri dalam menjalankan terapi merupakan salah satu penyebab kegagalan terapi. untuk meningkatkan kepatuhan yang berdampak kepada keberhasilan terapi sangat diperlukan pemberian informasi obat berupa konseling. Penelitian ini bertujuan mengetahui pengaruh konseling apoteker dapat mempengaruhi hasil outcome anemia berupa peningkatan kadar hemoglobin dan peningkatan kepatuhan minum obat pada siswi SMA. Subjek penelitian ini remaja putri di Sekolah Menengah Atas (SMA) di wilayah kerja puskesmas Mlati II selama bulan Januari - Agustus 2020. Desain penelitian ini adalah pretest posttest with control group design dengan metode pengambilan sampel simple random sampling. Sebanyak 68 remaja putri dikelompokkan secara random menjadi kelompok yang memperoleh intervensi konseling (35 remaja putri) dan kelompok tanpa intervensi atau kontrol (33 remaja putri). Subjek penelitian diikuti selama 30 hari untuk mengamati outcome anemia berupa penigkatan kadar hemoglobin dan tingkat kepatuhan minum obat TTD siswi SMA sebelum dan sesudah konseling. Hasil intervensi berupa konseling oleh apoteker yang dibandingkan dengan kelompok kontrol terbukti meningkatkan kepatuhan pasien dalam pengobatan secara bermakna (p=0,020). Tingkat kepatuhan remaja putri kelompok kontrol sebelum dan setelah penelitian diketahui tidak berbeda signifikan (p≥0,05). Pemberian konseling mampu meningkatkan kadar hemoglobin yang dibandingkan dengan kelompok kontrol (p=0,042). Meskipun kadar hemoglobin kedua kelompok sebelum dan setelah penelitian mengalami peningkatan yang signifikan (p≤0,05).
Analisis Rasionalitas Penggunaan Antibiotik Empiris Dan Definitif Pada Terapi Pneumonia Dan Profil Antibiogram di Rumah Sakit Akademik Universitas Gadjah Mada
Authors: Savitri Annisa Aulia , Nuryastuti Titik , Puspitasari Ika 
Published: April 2022

Pneumonia merupakan salah satu penyakit infeksi saluran pernafasan bawah yang menjadi penyebab kematian terbesar di negara berkembang terutama di Indonesia dengan persentase kematian sebesar 4,5% (2013). Yogyakarta sedikit lebih tinggi dari nilai nasional yaitu 4,6%. Pneumonia merupakan penyakit infeksi terbesar di RS Akademik UGM. Penelitian ini menggunakan metode penelitian deskriptif analitik dengan rancangan penelitian cross sectional dan pengambilan data secara retrospektif. Pengambilan data rekam medis pasien tahun 2018-2019 ditujukan untuk menyusun profil antibiogram dan untuk mengetahui hubungan rasionalitas pemilihan antibiotik empiris maupun definitif dengan kesembuhan pasien yang terdiagnosa pneumonia dengan metode Gyssens. Analisis data statistik menggunakan software SPSS versi 23rd dengan analisis bivariate dan uji chi square test. Pada penelitian didapatkan 98 pasien masuk dalam kriteria inklusi. Dari 98 pasien pneumonia diketahui 83 pasien diberikan terapi antibiotik empiris dan 15 pasien diberikan kombinasi antibiotik empiris dan definitif. Hasil evaluasi kesesuaian penggunaan antibiotik empiris dan definitif berdasarkan Guideline IDSA/ATS dan PPAB RS Akademik UGM pada pasien pneumonia rawat inap di RS Akademik UGM menunjukkan 38,5% pasien yang mendapatkan antibiotik empiris dan definitif yang sesuai dan tidak mempengaruhi clinical outcome. Gambaran bakteri yang ditemukan di RS Akademik UGM adalah bakteri gram negatif (77,7%) dan bakteri gram positif (22,2%).