bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mammalian Target of Rapamycin Inhibitors and Kidney Function After Thoracic Transplantation: A Systematic Review and Recommendations for Management of Lung Transplant Recipients
Authors: Schmucki Katja , Hofmann Patrick , Fehr Thomas , Inci Ilhan , Kohler Malcolm , Schuurmans Macé M. 
Published: December 2022

Background.
Chronic kidney disease (CKD) after lung transplantation is common and limits the survival of transplant recipients. The calcineurin inhibitors (CNI), cyclosporine A, and tacrolimus being the cornerstone of immunosuppression are key mediators of nephrotoxicity. The mammalian target of rapamycin (mTOR) inhibitors, sirolimus and everolimus, are increasingly used in combination with reduced CNI dosage after lung transplantation.

Methods.
This systematic review examined the efficacy and safety of mTOR inhibitors after lung transplantation and explored their effect on kidney function.

Results.
mTOR inhibitors are often introduced to preserve kidney function. Several clinical trials have demonstrated improved kidney function and efficacy of mTOR inhibitors. The potential for kidney function improvement and preservation increases with early initiation of mTOR inhibitors and low target levels for both mTOR inhibitors and CNI. No defined stage of CKD for mTOR inhibitor initiation exists, nor does severe CKD preclude the improvement of kidney function under mTOR inhibitors. Baseline proteinuria may negatively predict the preservation and improvement of kidney function. Discontinuation rates of mTOR inhibitors due to adverse effects increase with higher target levels.

Conclusions.
More evidence is needed to define the optimal immunosuppressive regimen incorporating mTOR inhibitors after lung transplantation. Not only the indication criteria for the introduction of mTOR inhibitors are needed, but also the best timing, target levels, and possibly discontinuation criteria must be defined more clearly. Current evidence supports the notion of nephroprotective potential under certain conditions.
A delay-specific neural indicator corresponds to delay-discounting behavior for both gain and loss
Authors: Kinjo Takuji , Yamagata Toyoki , Katayama Jun’ichi , Murata Asuka 
Published: December 2022

Objectives
Delay-discounting, wherein the subjective value for delayed gain or loss decreases, has been attracting much attention from the social sciences as well as neuroscience and has been suggested asbeing related to reward processing in the brain. As reported, the feedback-related negativity (FRN), an electrophysiological measure of reward processing, increased by delayed-monetary gain and ΔFRN, which is the difference in FRNs for loss and gain at a certain time point, had no significant correlation with delay-discounting for gain. Thus, although a delay for gain could affect FRN, it is unclear whether FRN capturing such a delay effect has a direct relationship with delay-discounting in both gain and loss domains.

Methods
In this study, we introduced a delay-specific indicator, ΔFRN

delay
, that is, the difference between FRN with and without delays, and investigated its direct relationship during the doors task with the discounting rate measured by the delay-discounting task in both the gain and loss domains.

Results
We found that, for loss, the delay enhanced FRN, whereas no such effect was observed for gains, and that this indicator was significantly correlated with delay-discounting in both domains.

Conclusions
To our knowledge, this study is the first to suggest that FRN is sensitive to the effects of delay in losses on reward processing and that the new indicator directly corresponds to changes in subjective value as measured by delay-discounting.
Structural Insights into Pink-eyed Dilution Protein (Oca2)
Authors: Mesdaghi Shahram , Murphy David L. , Simpkin AJ , Rigden Daniel J. 
Published: December 2022

AbstractRecent innovations in computational structural biology have opened an opportunity to revise our current understanding of the structure and function of clinically important proteins. This study centres on human Oca2 which is located on mature melanosomal membranes. Mutations of Oca2 can result in a form of oculocutanous albinism which is the most prevalent and visually identifiable form of albinism. Sequence analysis predicts Oca2 to be a member of the SLC13 transporter family but it has not been classified into any existing SLC families. The modelling of Oca2 with AlphaFold2 and other advanced methods shows that, like SLC13 members, it consists of a scaffold and transport domain and displays a pseudo inverted repeat topology that includes re-entrant loops. This finding contradicts the prevailing consensus view of its topology. In addition to the scaffold and transport domains the presence of a cryptic GOLD domain is revealed that is likely responsible for its trafficking from the endoplasmic reticulum to the Golgi prior to localisation at the melanosomes and possesses known glycosylation sites. Analysis of the putative ligand binding site of the model shows the presence of highly conserved key asparagine residues that suggest Oca2 may be a Na+/dicarboxylate symporter. Known critical pathogenic mutations map to structural features present in the repeat regions that form the transport domain. Exploiting the AlphaFold2 multimeric modelling protocol in combination with conventional homology modelling allowed the building of a plausible homodimer in both an inward- and outward-facing conformation supporting an elevator-type transport mechanism.
Single Cell transcriptional analysis ofex vivomodels of cortical and hippocampal development identifies unique longitudinal trends
Authors: Krizay Daniel K. , Goldstein David B. , Boland Michael J. 
Published: December 2022

SummaryPostnatal cortical and hippocampal mouse primary neuronal cultures are powerful and widely-used models of neuronal activity and neurological disease. While this model is frequently used to recapitulate what is seenin vivo, how the transcriptomic profiles of neuronal networks change over development is not fully understood. We use single-cell transcriptomics to provide a view of neuronal network establishment and maturation. Our data highlight region-specific differences and suggest how cell populations program the transcriptome in these brain regions. We demonstrate that patterns of expression markedly differ between and within neurological diseases, and explore why these differences are found and how well they compare to other models. In particular, we show significant expression differences between genes associated with epilepsy, autism spectrum disorder, and other neurological disorders. Collectively, our study provides novel insights on this popular model of development and disease that will better inform design for drug discovery and therapeutic intervention.Abstract FigureGraphical Abstract(A) Schematic representing select gene expression progression through neuronal network maturation from human cortical organoids (3- and 6-Month Organoid), newborn mice (P0 Mouse), immatureex vivocortex derived cultures (DIV 3ex vivo), functionally matureex vivocortex derived cultures (DIV15-31ex vivo), and adult mice (P56 Mouse). Color represents proportion of excitatory neurons with detectable expression for selected representative genesMapk10, Igfbp2, which increase and decrease through network maturation, respectively.(B) Schematic representing divergent expression patterns between genes associated with epilepsy and ASD through network maturation between the organoids andex vivocultures shown in (A). Color scales represent the change in the percentile, in respect to all genes, of the proportion of excitatory neurons with detectable expression.
Subcellular location defines GPCR signal transduction
Authors: Radoux-Mergault Arthur , Oberhauser Lucie , Aureli Simone , Gervasio Francesco Luigi , Stoeber Miriam 
Published: December 2022

AbstractG protein-coupled receptors in intracellular organelles can be activated in response to membrane permeant ligands, which contributes to the diversity and specificity of agonist action. The opioid receptors (ORs) provide a striking example, where opioid drugs activate ORs in the Golgi apparatus within seconds of drug addition. Till date, our knowledge on the signaling of intracellular GPCRs remains incomplete and it is unknown if the downstream effects triggered by ORs in plasma membrane and Golgi apparatus differ. To address this gap, we first assess the recruitment of signal transducers to ORs in both compartments. We find that Golgi-localized ORs couple to Gαi/o probes and are phosphorylated by GPCR kinases (GRK2/3), but unlike plasma membrane receptors, do not recruit β-arrestin or a specific Gα probe. Subsequent molecular dynamics simulations with OR–transducer complexes in model bilayers mimicking plasma membrane or Golgi composition reveal that the lipid environment promotes location selective coupling. Unbiased global analyses then show that OR activation in the plasma membrane and Golgi apparatus has strikingly different downstream effects on transcription and protein phosphorylation. Taken together, the study delineates OR signal transduction with unprecedented spatial resolution and reveals that the subcellular location defines the signaling effect of opioid drugs.
Additive effects of Zamzam water in reducing fasting blood glucose and LDL-cholesterol in rats fed on a ketogenic diet
Authors: AlJuwaie Ghadeer Fouad , Latif Rabia , Alsheikh Mona Hmoud , Alsunni Ahmed , Chathoth Shahanas 
Published: December 2022

PurposeThe ketogenic diet (KD) has gained popularity due to its ability to improve type 2 diabetes, weight loss, antioxidant and anti-inflammatory activity. However, long-term use of the KD might not be safe due to its adverse effects. This study examined the effects of the KD alone or in combination with Zamzam water (holy water for Muslims) on glucose homeostasis, lipid parameters and oxidant-antioxidant variables in rats.Design/methodology/approachBased on the diet given for ten weeks, three groups of adult male Wistar rats were made (12 rats/group): (1) rats which fed on a chow diet and ordinary water, (2) rats which fed on KD and ordinary water and (3) rats which were given KD along with Zamzam. Fasting blood glucose (FBG), serum insulin, insulin resistance (HOMA-IR), LDL cholesterol, HDL cholesterol, superoxide dismutase and malondialdehyde were compared by one-way ANOVA followed by post-hoc Tukey’s HSD test among groups.FindingsRats which fed on KD and Zamzam water had significantly reduced FBG and LDL cholesterol compared to the rats which fed on a chow diet and ordinary water (p-values 0.001), and KD and ordinary water (p-value 0.004 and 0.006, respectively). Serum insulin, insulin resistance, HDL cholesterol, superoxide dismutase and malondialdehyde did not differ significantly.Originality/valueConsumption of KD along with Zamzam for ten weeks significantly reduces FBG and LDL cholesterol. KD alone does not decrease these parameters in ten weeks duration.
Integrating green human resource management and circular economy to enhance sustainable performance: an empirical study from the Qatari service sector
Authors: Obeidat Shatha M. , Abdalla Shahira , Al Bakri Anas Abdel Karim 
Published: December 2022

PurposeThis study aims to contribute to the current Green human resource management (HRM) field by providing an empirical examination of a comprehensive model that tests the effect of green strategic intent on Green HRM implementation, the possible effect of Green HRM and green empowerment on circular economy, and the effect of circular economy on sustainable performance. It examines the mediating effect of circular economy on the link between Green HRM and sustainable performance.Design/methodology/approachThe study is empirical in nature. It focuses on the service sector in Qatar. Managers that work in the service sector represent the study participants. 149 questionnaires were collected and 131 completed questionnaires were used in the analysis. An advanced Partial Least Squares Structural Equation Modeling (SEM-PLS) analysis was conducted to reveal the study results.FindingsThe study findings confirmed the positive effect of green strategic intent on Green HRM, the positive link between Green HRM and green empowerment on circular economy, and the positive relationship between circular economy and sustainable performance. It also confirms the indirect effect of circular economy on the link between green HRM and sustainable performance.Research limitations/implicationsBecause of the chosen research approach and the focus on the service sector in Qatar only, research results may lack generalizability.Practical implicationsThis study provides important implications for practice on how to improve Green HRM practices; particularly for its unique context, the Qatari service sector.Originality/valueThis study is considered original since it is one of the few to examine a conceptual framework that links Green HRM, circular economy and sustainable performance.
Employees’ helping behavior toward the victims of human trafficking in the lodging industry
Authors: Farboudi-Jahromi Melissa , Tasci Asli D.A. , Sönmez Sevil 
Published: December 2022

PurposeThis study aims to examine the factors that influence hotel/motel employees’ helping behavior toward the victims of human trafficking.Design/methodology/approachUsing a survey-based quantitative method, this study examines and compares two models of helping behavior based on egoism and altruism theories to measure the helping tendencies of lodging employees toward victims of human trafficking.FindingsThe study results show that perceived intrinsic rewards of helping and empathy with the victims are the major antecedents of employees’ likelihood to help the victims.Research limitations/implicationsThe study contributed to the egoism school of thought and the Cost-Reward Model by showing that only perceived intrinsic rewards drive individuals’ intention to help in risky covert situations, such as human trafficking, while perceived extrinsic rewards may demotivate people to help in these situations.Originality/valuePrevious studies overlooked the role of the lodging industry in human trafficking. This study focuses on service employees as potential helpers of the victims as they notice in hotels/motels.
Chernobyl dreams: investigating visitors’ storytelling in the Chernobyl exclusion zone
Authors: Ojala Veera 
Published: December 2022

Purpose
Little is known about the overall meaning of the Chernobyl exclusion zone (CEZ) from the visitors’ point of view. Conceptualizing the zone as a storyscape and its narratives as intangible heritage resources, this study aims to investigate the visitors’ engagement with these resources and the resulting articulations from the engagements as translated into verbal and visual storytelling.

Design/methodology/approach
Participant observation and participant generated images in combination with in-depth interviews with different types of tourists were conducted. This paper uses the photographs chosen by the interviewees themselves as a photo essay to explore the evocation of stories through narrative engagement.

Findings
Through participant-oriented research, this study identified three dominant storytelling themes through which visitors focus their understanding of the CEZ. Visitors’ narrative engagements and visual storytelling co-produce the site and entail fluid and even conflicting narrative articulations about the CEZ and its cultural significance.

Research limitations/implications
The discoveries of this study stem from a unique developing heritage site. This study provided a more nuanced understanding of the different visitor categories in the CEZ and their group-specific ways to articulate, imagine and co-produce the storyscape of Chernobyl.

Originality/value
Gaining insight into the verbal and visual storytelling of tourists will contribute to the discussion of narrative consumption of different consumption profiles in tourism sites in addition to the mediation and construction of entangled memory spaces.
The role of student peers in HE student mental health and well-being
Authors: Smith Joanne , Hughes Gareth , Spanner Leigh 
Published: December 2022

Purpose
There is evidence that students’ experiences in higher education can be adversely affected by mental health issues, whilst well-being can be bolstered through a sense of belonging. This study aims to draw from Student Minds research into student mental health to consider the importance of peers to constructing a sense of belonging.

Design/methodology/approach
This paper draws from a thematic review of 12 focus groups – involving student services staff in six UK universities (69 participants) – conducted as part of the consultation and creation of the Student Minds University Mental Health Charter. The schedule considered student support, service structures and developments to enhance student well-being and manage mental health risks.

Findings
A significant theme explored here is the positionality of student peers in terms of relatability, and the importance of orientation and belonging for student mental health and well-being. The findings also consider types of peer involvement (formal/informal) and the influence of structure, training and boundaries in interventions.

Research limitations/implications
Findings reveal the importance of feeling a sense of belonging in the university community to achieve well-being and good mental health. Peer support is an important contributor that supports transitions into university and creates a sense of belonging, which is important to all students, but more so to those less familiar with university, who lack role models and more easily feel isolated.

Practical implications
The research has implications for higher education providers, which should inform the promotion of peer support within student services, based on the recognised contribution to well-being and mental health. This is important for student success and related opportunities.

Social implications
Success in higher education will open opportunities and create improved future prospects for individuals. This will not be realised for individuals who face boundaries and barriers to successful transition through university. The importance of belonging and role of peer support has implications for those who find themselves excluded in society.

Originality/value
This is a qualitative study which gives voice to individuals in universities across the UK. The theme of peer support within this context and linked with mental health and well-being is underexplored.
Application of predetermined motion and time system in sewing automat to enhance the productivity and operator utilisation
Authors: Mondal Priyabrata , Jana Prabir 
Published: December 2022

Purpose
Automation and the new buzzword, “Industry 4.0”, have dominated the media headlines in recent months. In this scenario, apparel manufacturers should not only install automatic machines but also standardise them based on specific industry requirements, and precise measures are required for daily target demands.

Design/methodology/approach
This study demonstrates the application of Predetermined Motion and Time System (PMTS) tools in various automatic and semiautomatic machines to obtain higher productivity and the highest utilisation percentage of operator and automats between the 1:1 and 1:2 man vs machine configuration models. In this study, timeSSD® was used to calculate the micro motions of humans. In addition, a video annotation and modelling software Tracker was used to calculate high-speed machine movements with loading frames of 30 FPS.

Findings
After the implementation of PMTS tools, it was found that for a 1:1 man vs machine configuration, the operator utilisation is 75% per shift and the operator idle time is 50% per cycle time, and the operator is sitting idle for 2 h per 8 h of shift. So, there is scope to improve the utilisation and idle time of operator.

Research limitations/implications
With the PMTS software, an industrial engineer professional with knowledge of the micromotion economy can only calculate micromotion.

Originality/value
Exploring the first time in the world to establish standard allowed minute (SAM) of a partly automated single-unit sewing machine with partial human intervention and a semiautomatic machine. Theoretical underpinnings indicate that manufacturers use the experience to determine the SAM of any operation over time, necessitating this work to calculate standard minutes automatically.
Tourism towards the well-being of Small Island Developing States: Tourism Agenda 2030
Authors: Puig-Cabrera Miguel , Martínez-del Vas Ginesa , Beltrán-Bueno Miguel Ángel , Nuevo-López Abraham 
Published: December 2022

Purpose
The purpose of this study is to contrast the capacity of tourism-specialized and non-tourism-specialized systems in small developing insular societies to achieve a well-being model aligned with the Agenda 2030.

Design/methodology/approach
The empirical method of this work consists of a panel-corrected standard errors analysis for a total of seven Caribbean Small Island Developing States (SIDS) to measure the contribution of both economic diversification and tourism specialization to well-being in the Agenda 2030 framework. Time period considered in the analysis include 2005–2019.

Findings
Linear and nonlinear relationships reveal the need to conjugate both tourism specialization and economic diversification in the 2030-development agendas of small developing insular societies as both represent a means to achieve a well-being model aligned with the Agenda 2030.

Originality/value
One of the main novelties of this work is that development is analyzed from a multidimensional point of view (standard of living, access to education and health services), as an integrated thinking that considers any tourism development model that defines a route with Sustainable Development Goals (SDGs) and Agenda 2030 as main destination in SIDS. Specifically, practical implications are given combining recommendations to foster development and face poverty (SDG-1), while inequalities situations are reduced (SDG-10) and decent jobs are generated (SDG-8). These implications also focus on strengthening local suppliers of goods and services from other sectors to be integrated into the destination value chain (SDG-2), ensuring access to education (SDG-4) and contributing to gender equality (SDG-5).