bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Motivators for Family Planning Utilization Among Youth Students in Higher Learning Institutions in Dodoma, Tanzania. Cross Sectional Study
Authors: Munuo Upendo , Moshi Fabiola Vincent 
Published: December 2022

Abstract
Background: Sub-Sahara Africa (SSA) has the greatest unmet need for family planning use, and young people are reported to under-utilize family planning services compared to other groups of women of the reproductive age in the region. Promoting contraceptive services use among adolescents is vital in achieving universal access to sexual and reproductive health services.
Objective: The main objective of this study was to assess motivators for family planning services utilization among higher learning youth students in Dodoma Tanzania.
Methods: An analytical cross-sectional study was conducted among 421 randomly selected youths in higher learning institutions in Dodoma. Data were collected through self-administered structured questionnaire adopted from previous studies. Bivariate and multivariate logistic regression analysis using SPSS version 25 established association between variables. Statistical significance was declared at 95% confidence interval with α<0.05 and strength of association was reported by Odds Ratio (OR) and Adjusted Odds Ratio (AOR).
Results: Majority of participants 221 (52.5%) were females, and most of them 320 (76.0%) were aged between 21 to 24 years. In addition, the majority were bachelor degree scholars 257 (61.0%). About 305 participants, which equals to 72.4% reported to have had sexual intercourse in the past 12 month. Those who reported to have ever had sexual intercourse, 50.5% had their first intercourse at the age between 15 to 19 years. Most participants 239 (56.8%) reported to have used contraceptive method in the past 12 months.
After adjusting for confounders (participants’ socio-demographic characteristics), the motivators for family planning use among youth students were, living with relatives (AOR = 2.904, p = 0.006), adequate FP knowledge (AOR = 2.230 p = 0.003), positive perception (AOR = 1.772, p = 0.025) and discussing FP matters with sexual partners (AOR = 6.045, p= <0. 001).
Conclusion: The study has revealed that prevalence of FP use among higher learning students was relative higher. This was determined by discussing contraceptive matters with sexual partners, living with relatives other than their parents, adequate FP knowledge and positive perception towards FP utilization.
Low utilisation of treatment services among youths with crystal meth use-related problems. Findings from working with Mubatirapamwe, a treatment service provider in Harare, Zimbabwe
Authors: Nyashanu Tichaenzana , Nyashanu Mathew , Zawaira Tendai , Zirima Herbert 
Published: December 2022

Abstract

Introduction: Globally, harmful substance use, coupled with low utilisation of treatment services, is a public health concern. This study sought to explore and measure the various factors responsible for the low utilisation of treatment services among youths using crystal meth in Harare, Zimbabwe. Also, the role of biographic and socio-demographic variables in the utilisation of treatment services was scrutinised.
Methods: Participants were randomly sampled from various urban residential settlements across Harare, living with meth use-related problems and participating in the Mubatirapamwe treatment program. Youths aged between 18-30 years participated in a survey, using the pen and questionnaire self-report method. Descriptive statistics were used to analyse the data.
Results: Factors such as stigma and privacy issues, lack of perceived need for change, lack of readiness to change, and financial constraints emerged as some of the most significant deterrents to utilisation of treatment services. The role of biographic and socio-demographic variables such as gender, race, and employment status were examined in the context of utilisation of treatment services.
Conclusions: Mobilisation of resources to drive substance use programs, heighten awareness on substance use related matters, and the integration of substance use treatment programs with primary healthcare are key strategies to bridging the treatment gap. Further research is recommended to explore the role of biographic and socio-demographic variables in the utilisation of treatment services. Recommendations were made for accelerated and expanded research in order to inform practice, by developing context-specific interventions.
The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer by enhancing the endocytosis and recycling of TrkB in tumour cells
Authors: Zhou Yao-Qi , Bao Tian-Shang , Xie Jia-Xuan , Yao Lin-Li , Yu Si-Te , Huang Pei-Qi , Li Qing , Chen Su-Yuan , Zhou Wan-Zhen , Wang Xiao-Qi , Zhang Xue-Li , Jiang Shu-Heng , Yi Shuang-Qin , Zhang Zhi-gang , Ma Ming-ze , Hu Li-Peng , Li Jun , Xu Jia 
Published: December 2022

Abstract
Purpose
Gastric cancer (GC) is a malignant tumour with high mortality, and liver metastasis is one of the main causes of poor prognosis. SLIT- and NTRK-like family member 4 (SLITRK4) plays an important role in the nervous system, such as synapse formation. Our study aimed to explore the functional role of SLITRK4 in GC and liver metastasis.
Methods
The mRNA level of SLITRK4 was evaluated using publicly available transcriptome GEO datasets and Renji cohort. The protein level of SLITRK4 in the tissue microarray of GC was observed using immunohistochemistry. Cell Counting Kit-8, colony formation, transwell migration assays in vitro and mouse model of liver metastatasis in vivo were performed to investigate the functional roles of SLITRK4 in GC. Bioinformatics predictions and Co-IP experiments were applied to screen and identify SLITRK4-binding proteins. Western blot was performed to detect TrkB-related signaling molecules.
Results
By comparing primary and liver metastases from GC, SLITRK4 was found to be upregulated in tissues of GC with liver metastasis and to be closely related to poor clinical prognosis. SLITRK4 knockdown significantly abrogated the growth, invasion, and metastasis of GC in vitro and in vivo. Further study revealed that SLITRK4 could interact with Canopy FGF Signalling Regulator 3 (CNPY3), thus enhancing TrkB-related signaling by promoting the endocytosis and recycling of the TrkB receptor.
Conclusion
In conclusion, the CNPY3-SLITRK axis contributes to liver metastasis of GC according to the TrkB-related signaling pathway. which may be a therapeutic target for the treatment of GC with liver metastasis.
The Relation between Gastroesophageal Reflux Disease and the Obstructive Sleep Apnea and the Effects of Continuous Positive Airway Pressure Treatment
Authors: Deng Jingjing , Li Xia , Wu Xiaoqing , Xue Qian , Deng Lihua , Li Menghan , Wang jingtong 
Published: December 2022

Abstract
Background: Patients with OSA have a higher risk of GERD than non-OSA patients. However, there is a controversy between the OSA and GERD. Herein, we evaluated the prevalence and possible risk factors of GERD in OSA. We also observed the efficacy of continuous positive airway pressure (CPAP) therapy on these patients.
Method: Home Sleep Apnea Test (HAST) and gastroesophageal reflux disease questionnaire (GERDQ) are used to diagnose OSA and GERD. A total of 600 OSA patients were concluded in this cross-sectional study. Of the patients with OSA complicated with GERD, 36 received CPAP, 24 received CPAP + proton pump inhibitor (PPI), and 33 received PPI. We followed patients with OSA complicated with GERD for 8 weeks.
Result: This study identified a significant relationship between OSA and GERD, with a OR of 2.76 (95%CI 1.42-5.36, P=0.02). The prevalence of GERD in patients with mild, moderate, and severe OSA was 14.9%, 15.9%, and 56.9%, respectively. After 8 weeks of treatment, the GERDQ in the CPAP group was 6.89±1.14. The duration of symptom improvement in CPAP group was 5.43±2.02 weeks. The duration of symptom improvement in CPAP+PPI group was 4.23±1.6 weeks. and higher PPI discontinuation rate in CPAP+PPI group is 54.2%, and PPI group is 27.3%.
Conclusion: OSA was independently associated with GERD. CPAP improved GER symptoms compared with the no-treatment group. CPAP+PPI treatment improved GERD more rapidly than PPI alone, and CPAP treatment was an independent protective factor for GERD.
Lipid metabolism and antioxidant system contributed to salt salinity tolerance induced by Na+ accumulation in halophytic grass seashore paspalum
Authors: Pan Ling , Hu Xu , Shen Qing , Liao Li , Xu Tingchen , Sun Quanquan , Xu Tao , Tang Minqiang , Chen Zhenbang , Wang Zhiyong 
Published: December 2022

Abstract
Background and aims
Soil salinization is a growing problem for agriculture worldwide. To elucidate the mechanism underlying the salt tolerance of halophytes can offer a new angle for developing salt−tolerant crops. Seashore paspalum (Paspalum vaginatum Sw.) is a halophytic turfgrass and genomic model system for salt tolerance research in cereals and other grasses. However, knowledge regarding the tolerance mechanism of this halophyte remains largely unknown.
Methods
The two P.vaginatum accessions with contrasting salinity tolerance were employed to investigate the relationship between Na+ accumulation, lipid metabolism, antioxidant response and tissue−dependent salt tolerance using ICP−MS−based ion analysis, lipidomic profiling analysis, enzyme assay and integrated transcriptomic and metabolomic analysis, respectively. Gene−metabolite network analysis was carried to identify the significant TF genes and metabolites associated with salt tolerance in P.vaginatum plants.
Results
We found that salt−tolerant P.vaginatum built up tissue−specific strategies accompanied with Na+ accumulation in response to salt stress. Antioxidant system and amino acid metabolism were curial to maintain high salinity tolerance in leaves of P. vaginatum plants. On the contrary, lipid upregulation is the important components of the salt−tolerant mechanism in roots of P. vaginatum. Furthermore, 109 TF genes were identified to be linked to salt tolerance, conferring to salinity tolerance in this halophytic grass.
Conclusions
Our results expand our understanding of the underlying salt tolerance of seashore halophyte grass for the breeding and genetic engineering of salt tolerance in crop plants.
Development of coal fly ash modified graphite-polyurethane composite electrodes for the determination of Cd(II) in batteries and water
Authors: Barros Caio Ribeiro , Cervini Priscila , Buoro Rafael Martos , Merwe Elizabet M. , Cavalheiro Éder T. G. 
Published: December 2022

Abstract
Coal fly ash (FA), an aluminium silicate by-product and environmental pollutant which is generated during the combustion of coal in coal-fired power stations, was used for the first time as an electrode modifier for the determination of metallic cations. Thus, graphite/polyurethane-based composites containing different amounts of FA were prepared and characterized by SEM, EDX and TGA/DTG. The graphite/polyurethane composite electrodes (GPUE), with and without FA modifier, were evaluated with regard to their performance as voltammetric electrodes in the determination of metallic cations, using Cd(II) as a probe. After optimizing solution and instrumental parameters affecting the voltammetric peak current, a differential pulse anode stripping voltammetry (DPASV) procedure was developed for GPUE modified with 5% FA (m/m), resulting in a linear response for Cd(II) in the range 2.0 x 10‑7 to 1.0 x 10‑6 mol L-1 with a detection limit (LOD) of 6.6 x 10-8 mol L-1. Cd(II) was added to natural water samples and determined in concentrations at 10-7 mol L-1 level, with a mean recovery of 99%. It was also extracted from exhausted rechargeable Ni-Cd batteries and diluted to ca. 0.2 µmol L-1 and determined with the same electrode, with recoveries of 98.7% when compared to FAAS. These results serve as a proof of concept that FA is a useful electrode modifier for determination of cationic species.
Environmental impact assessment and normalization of different expressway sub-projects during construction
Authors: Huang Yimiao , Zhao Xiaokuan , Zhang Ruochen , Xie Panpan , Xue Guixiang , Ma Guowei 
Published: December 2022

Abstract
The construction process of expressway is characterized by high energy and materials consumption, which poses overwhelming potential threat to the physical environment. In order to coordinate contradiction between expressway construction and concomitant environment issues, this study quantitatively assessed environmental impact of different sub-projects and presented an environmental price model to characterize the overall environmental impact of construction materials in normalized methods. The results showed that the bridge, culvert, and tunnel sub-projects produced the most significant environmental impact. Compared with onsite construction and transportation, material production, which is mostly associated with a few types of construction materials, contributed the largest proportion (approximately 90%) of the life cycle environmental impact. Cement, explosives, and wood contributed significantly to global warming potential, substance of ozone depletion, and land use contributing 51.55%, 70.87%, and 54.95%, respectively, in the subgrade sub-project. The environmental impact ratio can indicate the degree of matching between the environmental impact of a material and its preparation technologies. When the environmental impact ratio is high, a focus on green update and iteration of production technologies of such construction materials are required. This study identifies the environmentally sensitive links of different expressway construction sub-projects and provides a decision-making basis for the selection of construction materials and upgradation and iteration of production technologies from the perspective of environmental price, thus providing scientific guidance to green expressway construction.
A Sentiment Analysis method of Weibo topic based on BiGRU-Attention and its application in network public opinion
Authors: Li Heming , Bai Zhongxian , Wang Weijia 
Published: December 2022

Abstract
[Purpose/significance] Weibo is a Chinese social media platform based on user relationships. Users can comment on hot topics to express their emotions and emotional tendencies. Mining users' emotion and attitude from Weibo topic comments are helpful to the analysis of Weibo public opinion analysis, which has practical significance.
[Method/process] This paper proposes a sentiment analysis method that combines the bidirectional gated recurrent unit neural network (BiGRU) with the attention mechanism to construct an emotion classification model that takes into account training speed and accuracy. Experiments on public datasets show that compared with the classical neural network model, the model in this paper can effectively improve the accuracy of sentiment classification. Experiments are carried out on topics comment data of 10 different fields, and the results verify the feasibility and generalization ability of the model.
[Result/conclusion] Finally, a quick and effective sentiment prediction is made for the comments on hot topics, and the opinions and attitudes of netizens on hot topics are analyzed according to the calculated sentiment index and word cloud graph, so as to grasp the public’s emotional attitude towards public opinion events in time and provide a reference for the subsequent application of popular public event prediction and public opinion analysis and research.
[Limitations] There are also some shortcomings in this study, such as errors in sentiment analysis of comment sentences with complex semantics such as irony, and no fine-grained sentiment analysis, which still needs further research and improvement.
Off-Memory Decryption of Classified Documents
Authors: Suzer Mehmet Hadi 
Published: December 2022

Abstract
Secure transmission of information between parties needs robust cryptographic methods to be utilized. In general, information is delivered to its destination through non-secure channels in which a massive number of malicious users or machines may reside. Data sources use end to end encryption to bypass those threats, however, even after safe delivery, the information is still susceptible to altering or stealing attacks due to viruses, Trojans and other kind of threats hidden in end devices. The decrypted message residing in the memory of computers as plain text is vulnerable against malicious software or users which or who may copy, print or share it to unauthorized parties. In this paper, we present a cryptographic device which moves the decryption stage out of the memory of destination computers, so it is not subject to information stealing anymore. We present theory, implementation and evaluation of the approach in detail, and test results show that our device can capture video frames of Full HD resolution on an HDMI link, descramble and show them on the screen at 60 Hz frame rate successfully.
Socioeconomic disparities and concentration of the spread of the COVID-19 pandemic in the province of Quebec, Canada
Authors: Lefebvre Gabrielle , Haddad Slim , Moncion-Groulx Dominique , Saint-Onge Mélanie , Dontigny André 
Published: December 2022

Abstract
Background
Recent studies suggest that the risk of SARS-CoV-2 infection may be greater in more densely populated areas and in cities with a higher proportion of persons who are poor, immigrant, or essential workers. This study examines spatial inequalities in SARS-CoV-2 exposure in a health region of the province of Quebec in Canada.
Methods
The study was conducted on the 1206 Canadian census dissemination areas in the Capitale-Nationale region of the province of Quebec. The observation period was 21 months (March 2020 to November 2021). The number of cases reported daily in each dissemination area was identified from available administrative databases. The magnitude of inequalities was estimated using Gini and Foster-Greer-Thorbecke (FGT) indices. The association between transmission and socioeconomic deprivation was identified based on the concentration of transmission in socially disadvantaged areas and on nonparametric regressions relating the cumulative incidence rate by area to ecological indicators of spatial disadvantage. Quantification of the association between median family income and degree of exposure of dissemination areas was supplemented by an ordered probit multiple regression model.
Results
Spatial disparities were elevated (Gini = 0.265; 95% CI [0.251, 0.279]). The spread was more limited in the less densely populated areas of the Quebec City agglomeration and outlying municipalities. The mean cumulative incidence in the subsample made up of the areas most exposed to the pandemic was 0.093. The spread of the epidemic was concentrated in the most disadvantaged areas, especially in the densely populated areas. Socioeconomic inequality appeared early and increased with each successive pandemic wave. The models showed that areas with economically disadvantaged populations were three times more likely to be among the areas at highest risk for COVID-19 (RR = 3.55; 95% CI [2.02, 5.08]). In contrast, areas with a higher income population (fifth quintile) were two times less likely to be among the most exposed areas (RR = 0.52; 95% CI [0.32, 0.72]).
Conclusion
As with the H1N1 pandemics of 1918 and 2009, the SARS-CoV-2 pandemic revealed social vulnerabilities. Further research is needed to explore the various manifestations of social inequality in relation to the pandemic.
Linear-Time Algorithm for Paired-Domination on Distance-Hereditary Graphs
Authors: Mu Ta-Yu , Lin Ching-Chi 
Published: December 2022

Abstract
The study of domination problem and its variants is a classical area in algorithmic graph theory. One of the most famous variants of the domination problem is paired-domination as it has practical applications in security and surveillance services. Given a graph G, the paired-domination problem on G is to determine a minimum dominating set D such that the subgraph of G induced by D has a perfect matching. Lin et al. [Paired-domination problem on distance-hereditary graphs, Algorithmica, 2020] showed that the problem could be solved in O(n2) time. In this paper, we strengthen their results by providing an O(n+m)-time algorithm. Moreover, the algorithm can be completed in O(n) time if a decomposition tree of G is given.
The relationship between parents' social capital and psychological health among children and adolescents
Authors: Ahmadi Nastaran , Hosseini Fatemeh , shahabadi Akbar zare , Mohammadi Mohammad Reza , Khaleghi Ali , Yazdi Fatemeh Rismanian , Esmailnezhad Bahaneh , Khorshidi Rozita , Mirzaei Masoud 
Published: December 2022

Abstract

Objective: Childhood and adolescence are sensitive developmental periods that shape the personality of children and adolescents, this study investigates the relationship between parents' social capital and the psychological health of children and adolescents.
Methods: This is a cross-sectional study and using the multi-stage cluster sampling method, 1035 children and adolescents aged 6 to 18 and their parents were selected. The Lifestyle Questionnaire (LSQ) and the Social Capital Questionnaire were used to collect information.
Results: The results showed that there was a significant positive correlation between parents’ social capital and their children’s psychological health. Employed parents, insurance type, and fathers’ education levels had a significant correlation with children’s psychological health, and parents’ gender, age, and education levels had a significant correlation with their social capital.
Conclusion: With further research, the creation of health-promoting programs, changes in policy, and social capital may improve mental well-being and prevent mental illness.
Preparation of MnO 2 @poly (DMAEMA-co-IA) Conjugated methotrexate Nano-complex for MRI and Radiotherapy of Breast Cancer Application
Authors: Ziyaee Saba , Malekzadeh Reza , Ghorbani Marjan , Motlagh Behnam Nasiri , Asghariazar Vahid , Mortezazadeh Tohid 
Published: December 2022

Abstract
A novel efficient pH-sensitive targeted magnetic resonance imaging (MRI) contrast agent and innovative radiosensitizing system were synthesized based on MnO2 NPs coated with biocompatible poly (dimethylaminoethyl methacrylate -Co- itaconic acid) and targeted with methotrexate. The established NPs were characterized and MRI signal enhancement, relaxivity, cell targeting, toxicity, and radiotherapy efficacy were evaluated. The developed system displayed pH-responsive MRI contrast enhancement, differential uptake in malignant and normal cells, negligible in vitro cytotoxicity, and suitable in vitro cell targeting ability. Enhanced therapeutic efficacy in hypoxic conditions confirmed the efficiency of the system in MR imaging and radiation therapy of hypoxia cells.