bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vancomycin Containing PDLLA and PLGA/β-TCP Inhibit Biofilm Formation but Do Not Stimulate Osteogenic Transformation of Human Mesenchymal Stem Cells
Authors: Kankilic Berna , Bayramli Erdal , Korkusuz Petek , Eroglu Hakan , Sener Burcin , Mutlu Pelin , Korkusuz Feza 
Published: July 2022

AimsChronic osteomyelitis, including implant-related prosthetic joint infection, is extremely difficult to cure. We develop vancomycin containing release systems from poly(d,l-lactide) (PDLLA) and poly(d,l-lactide-co-glycolide) (PLGA) composites with beta-tricalcium phosphate (β-TCP) to treat methicillin-resistant Staphylococcus aureus osteomyelitis. We ask whether vancomycin containing PDLLA/β-TCP and PLGA/β-TCP composites will prevent early biofilm formation, allow cell proliferation and osteogenic differentiation, and stimulate osteogenic signaling molecules in the absence of an osteogenic medium.MethodsComposites were produced and characterized with scanning electron microscopy. In vitro vancomycin release was assessed for 6 weeks. Biofilm prevention was calculated by crystal violet staining. Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) and osteosarcoma cell (SaOS-2) proliferation and differentiation were assessed with water soluble tetrazolium salt and alkaline phosphatase (ALP) staining. Real-time quantitative polymerase chain reaction defined osteogenic signaling molecules for hBM-MSCs.ResultsTotally, 3.1 ± 0.2 mg and 3.4 ± 0.4 mg vancomycin released from PDLLA/β-TCP and the PLGA/β-TCP composites, respectively, and inhibited early biofilm formation. hBM-MSCs and SaOS-2 cells proliferated on the composites and stimulated ALP activity of cells. Runt-related transcription factor 2 (RUNX2) and SRY-Box transcription Factor 9 (SOX9) expressions were, however, lower with composites when compared with control.ConclusionVancomycin containing PDLLA/β-TCP and PLGA/β-TCP composites inhibited early biofilm formation and proliferated and differentiated hBM-MSCs and SaOS-2 cells, but osteogenesis-related RUNX2 and SOX9 transcription factors were not strongly expressed in the absence of an osteogenic medium for 14 days.
Toxicological Impact and in Vivo Tracing of Rhodamine Functionalised ZIF-8 Nanoparticles
Authors: Goyal Prateek , Soppina Pushpanjali , Misra Superb K. , Valsami-Jones Eugenia , Soppina Virupakshi , Chakraborty Swaroop 
Published: July 2022

Metal Organic Frameworks (MOFs) are extensively used for a wide range of applications due to their exceptionally high surface area. MOF particles are conventionally in micron size, but the nanosized MOFs show good transportation/mobility due to their small size, and when combined with the high surface area of MOFs, it makes MOF nanoparticles an ideal candidate to study for environmental remediation. Therefore, it is important to study the ecotoxicological impact of these MOFs. In this study, we developed rhodamine labelled nanoparticles of zinc imidazolate metal organic framework (ZIF-8 MOFs) as a means of in vivo tracing the MOF translocation in C. elegans. Rhodamine B isothiocyanate functionalized ZIF-8 MOFs nanoparticles (RBITC@ZIF-8 MOF nanoparticles; size 44 ± 7 nm) were fed to the worms naturally within a concentration range of 0.16–16.4 μg mg−1. Fluorescence was detected in the pharyngeal and gut lumen regions of the worms after 4 h of treatment, for exposure concentrations &gt;0.163 μg mg−1. A higher intensity of fluorescence was observed at the end of 24 h for all exposure concentrations. Worms treated with RBITC@ZIF-8 MOF concentrations of ≥1.63 μg mg−1 for 24 h showed a bright stable fluorescence signal at the tail region. The uptake of RBITC@ZIF-8 MOF for an exposure concentration of 0.163, 1.63, and 8.2 μg mg−1 was found to be 52.1, 11.4 and 28.6%, respectively. Through this study, we showed that RBITC@ZIF-8 MOFs can be exposed to C. elegans and imaged at low concentrations of ∼0.16 μg mg−1.
Associations Between Incident Asthma With Comorbidity Profiles, Night Sleep Duration, and Napping Duration Trajectories: A 7-Year Prospective Study
Authors: Hu Zhigang , Tian Yufeng , Song Xinyu , Hu Ke , Yang Ailan 
Published: July 2022

Objectives: We aim to determine whether comorbidity profiles, night sleep duration, and napping duration trajectories were associated with incident asthma in Chinese adults.Methods: A total of 7,655 community-dwelling individuals were included in this study. Latent class/profile analysis(LCA/LPA) identified comorbidity profiles, night sleep duration, and napping duration trajectories. A generalized additive model with binomial regression assessed the associations between incident asthma with sleep trajectories.Results: During a 7-year follow-up period, 205 individuals were newly diagnosed with asthma. LPA identified four trajectories of night sleep duration: dominant short (n = 2,480), dominant healthy-long (n = 1,405), long decreasing (n = 1875), and short increasing (n = 1895). We also found three trajectories of napping duration: short increasing (n = 3,746), stable normal (n = 1,379), and long decreasing (n = 2,530). We found three comorbidity profiles: dominant heart diseases or risks (n = 766), multiple disorders (n = 758), and minimal or least disorders (n = 6,131). Compared with dominant short night sleep duration, three other trajectories were associated with significantly decreasing incident asthma. Minimal or least disorders profile was associated with a significant reduction of new-onset asthma than two other comorbidity profiles in dominant short night sleep duration.Conclusion: Our findings suggested that a dominant short night sleep duration trajectory potentially increases incident asthma in Chinese adults.
Analisis Metode Weighted Product dalam menentukan Order Barang Terbaik pada Marketplace Shopee
Authors: Dodi Guswandi  , Hadi Syahputra  , M. Hafizh  , Rita  , Devia Kartika  
Published: July 2022

Order barang secara online pada Marketplace merupakan suatu kebiasaan masyarakat yang sangat populer saat sekarang ini, karena sangat mudah digunakan yang dapat menghemat waktu, biaya dan tenaga. Salah satu Marketplace yang banyak dikunjung oleh pelanggan adalah Marketplace Shopee, pada Marketplace ini banyak pelanggan kesulitan dalam menentukan item barang yang terbaik karena barang yang sama tersedia dibeberapa toko dengan karakteristik yang berbeda-beda, sehingga barang yang dipesan banyak tidak sesuai dengan apa yang diharapkannya. Penelitian ini bertujuan untuk menerapkan sebuah model analisis dalam menentukan order barang terbaik pada Marketplace Shopee menggunakan Sistem Pendukung Keputusan (SPK) dengan metode Weighted Product (WP). Kinerja dari metode WP mampu melakukan perkalian terbobot pada setiap kriteria setelah dipangkatkan dan hasil keputusan berupa perankingan menghasilkan solusi dalam penentuan order barang terbaik pada Marketplace Shopee. Kriteria yang digunakan terdiri dari Harga (C1), Kualitas Produk (C2), Online Customer Reviews (C3), Jumlah Barang yang Terjual (C4), Lama Pengiriman (C5), Sistem Pembayaran (C6), dan Diskon Ongkir (C7). Hasil penelitian ini yang disajikan dalam kinerja metode WP mampu menentukan nilai barang tertinggi dibeberapa Toko dalam jenis barang yang sama, setelah dilakukan hasil perankingan yaitu Item A Toko 5 memperoleh nilai 0,130237 sebagai order barang terbaik.
Individual psychological characteristics of law enforcement officers affecting the psychological readiness for action in extreme conditions
Authors: Zueva Evgeniya , Barinova Marina 
Published: July 2022

The article discusses individual psychological characteristics that determine the psychological readiness for action in extreme conditions. The authors define the concepts of «psychological readiness» and «extreme situations», as well as the features of extreme situations. The purpose of the study is to identify the individual psychological characteristics of law enforcement officers that affect the psychological readiness for action in extreme conditions, as well as their dependence on the duration of service. The practical significance of the study lies in the identification of psychological characteristics that affect the psychological readiness for activities in the event of a threat to life and health and, thus, the expansion of knowledge in the field of psychology of safety and human behavior in extreme and emergency situations. The study sample consisted of law enforcement officers who, in their professional activities, face situations of threat to life and health.
The work reveals individual psychological characteristics of law enforcement officers operating in extreme conditions. According to the results of the study, it has been revealed that the duration of service is interconnected with the following individual psychological characteristics: friendliness, communicativeness, caution, activity level, demonstrativeness, aggressiveness.
Current problems of administrative and administrative procedural law (Sorokin Readings) International scientific and practical conference (March 25, 2022, Saint Petersburg)
Authors: Kaplunov Andrey , Ukhov Vladimir 
Published: July 2022

On March 25, 2022 the Saint-Petersburg University of MIA of Russia held a plenary meeting of the international scientific and practical conference (Sorokin readings), dedicated to the memory of Yuri Efremovich Avrutin, doctor of law, professor, honored scientist of the Russian Federation, honored lawyer of the Russian Federation, and the 75th anniversary of his birth.
By the day of the conference, a collection of its materials was published in digital form. It included 152 scientific works prepared by 166 authors from 49 scientific and educational organizations, including 8 authors from 4 foreign countries (the Republic of Belarus, the Republic of Kazakhstan, the Republic of Uzbekistan, and Azerbaijan Republic). 23 doctors of law, 89 candidates of law, and 8 employees of police force of the Russian Federation took part in the creating of this compendium.
At the plenary session the participant shared their opinions and came to terms on the challenges of modernization of public administration, administrative and administrative procedural law, on theoretical and applied problems of improving legislation on administrative offenses and administrative-jurisdictional activities, questions of security and public order, development of the police and other law enforcement activities.
Learning Sustainable Locust Control Methods in Virtual Reality
Authors: Hahn Nathan , Fuchs Beatrice , Fortna Max , Cobb Elijah , Iqbal Muhammad Zahid 
Published: July 2022

<p> Invasion of locust swarms has affected the crops in many countries in Africa and Asia, which is a significant threat to food security. Therefore, different approaches are adopted to monitor and control the locust swarms to save the crops. Furthermore, it has been proved in various studies that technology can help in agriculture through drones, real-time data monitoring, or teaching the farmers with the latest tools. Following the UN sustainability goals for food security, this research has presented a Virtual Reality(VR) based educational application to teach sustainable locust management strategies. Using hand tracking technology in the Oculus Quest lets users learn how farmers can deal with locusts without pesticides. Based on a storytelling approach, the methods presented are profitable for the farmers and free of any harm to crops regarding food security. This application can help motivate the adoption of these sustainable locust control strategies in broader interventions for environmental recovery. </p>
Train academics to design and assess using learning outcomes: new challenges in Higher Education
Authors: Emanuel Federica 
Published: July 2022

The paper reflects on the topic of learning outcomes in Higher Education. The emphasis on the education process and learning benefits students, faculty, and institution. The theme of learning outcomes in relation to instructional design and assessment becomes the subject of faculty development programs; a three-level training is hypothesized and discussed, starting with the IRIDI training program for faculties at the University of Turin. The first level is the exploration of learning outcomes’ topic, which can start from the syllabus development. The second level refers to the reinforcement of the use of learning outcomes in the didactic and assessment practices. The last level emphasizes the importance of providing faculty with specific training, with a collegial and institutional focus. This training model will be able to support and promote student-centered, inclusive, and quality teaching in Higher Education.

Formare i docenti universitari a progettare e valutare secondo i learning outcomes: nuove sfide in Higher Education.
Il contributo presenta una riflessione sul tema dei learning outcomes nella didattica universitaria. L’attenzione per il processo didattico e l’apprendimento portano benefici per studenti, docenti e istituzione. Il tema dei learning outcomes in relazione alla progettazione didattica e alla valutazione diventa oggetto della formazione dei docenti universitari; viene ipotizzata e discussa una formazione a tre livelli, partendo dalla analisi del programma di formazione IRIDI per i docenti universitari dell’Università di Torino. Il primo livello è quello della esplorazione del tema dei learning outcomes, che può partire dalla redazione della scheda di insegnamento. Il secondo livello si riferisce al consolidamento dell’uso dei learning outcomes nella pratica didattica a valutativa dei docenti universitari. L’ultimo livello sottolinea l’importanza di offrire ai docenti una formazione specifica sul tema, con una attenzione collegiale e istituzionale. Questo modello di formazione potrà sostenere e promuovere una didattica centrata sullo studente, inclusiva e di qualità.
Giornate internazionali di studio sul paesaggio 2021 e 2022. Percepire il co-divenire incarnando alterità
Authors: Antoniolli Elena 
Published: July 2022

La recensione propone una prospettiva critica della diciassettesima edizione delle Giornate Internazionali di Studio sul Paesaggio organizzata da Fondazione Benetton Studi Ricerche incentrata sul rapporto tra corpi e paesaggi. Come partecipa la nostra adesione corporea al paesaggio? Qual è la misura dell’interazione sensoriale con esso? Come si evolve il rapporto tra corpo e paesaggio nell’Antropocene? Attraverso queste domande si articola la riflessione tra realtà percepita e corporeità, tra esperienza sensoriale e immaginario mitopoietico, in un connubio tra arte, antropologia, storia dell'arte dei giardini, cultura del paesaggio e danza. Ripercorrendo i ragionamenti dei dieci contributi che hanno nutrito il convegno, emergono affinità tematiche tra “essere” nel paesaggio e “sentire” il paesaggio.
Il coinvolgimento attivo e percettivo del corpo avviene grazie un’immersione reale nel paesaggio, ma anche attraverso la sua dimensione narrativa. Il corpo, specchio della paesaggio, muta nella sua fisicità e nella sua condizione psichica, richiamando un processo di metamorfosi reciproca e al contempo un approccio psicogeografico, in cui l’erranza ci invita ad accogliere l’Altro e l’ibridazione del paesaggio, secondo un neo-animismo del “sentire”.
Intravitrealversus Posterior Subtenon Triamcinolone Acetonide in Conjunction with Intravitreal Bevacizumab for Refractory Diabetic Macular Edema
Authors: Gull Ambreen , Khan Niazi Fuad Ahmad , Raza Ali 
Published: July 2022

Purpose
Aim of this study was to evaluate and compare the effects of combined simultaneous injection of intravitreal triamcinolone acetonide and bevacizumab versus intravitreal bevacizumab and posterior subtenon triamcinolone acetonide in treatment of persistent refractory diabetic macular edema after intravitreal bevacizumab injection failure
Methods
40 pseudophakic diabetic patients were enrolled in quasi experimental study conducted at ophthalmology department. All eyes were specifically diagnosed with persistent refractory diabetic macular edema with central retinal thickness of _____on OCT. Patients were divided into two groups. Group A was given simultaneous injection of intravitreal bevacizumab 1.25mg/0.05ml with posterior subtenon triamcinolone 40mg and group B was given intravitreal bevacizumab in conjunction with simultaneous intravitreal triamcinolone 2mg/0.05 ml.Patients were followed upmonthly till three months. Changes in the best corrected visual acuity, intraocular pressure and central retinal thickness by optical coherence tomography were evaluated in both groups. Retreatment was given at 12 weeks interval whenever indicated by OCT.
Results
Group B showed a more significant decrease in the median CRT at 1month (p =0.0002)but after 3 months both groups showed a reduction in CRT which was not statistically significant between two groups _____. Both groups had significant improvement in BCVA compared to pre-injection baseline visual acuity.Between two groups BCVA changes were not statistically significant at 3 months _____.Five eyes in group B developed IOP beyond 22mmHg, which was treated with anti glaucoma medications within 2 weeks. No eye in group A developed IOP greater than 21mmHg. At 12 weeks, 7 of group A patients and 6 of group B patients developed recurrent macular edema and required repeated injections.
Conclusion
While treating persistent refractory diabetic macular edema, posterior subtenon triamcinolone is as effective as intravitreal triamcinolone in conjunction with intravitreal bevacizumab in reducing CRT and improving and stabilizing BCVA but in terms of IOP rise posterior subtenon injection is safer as compared to intravitreal injection. Both treatments are cost effective and combined simultaneous injections decrease the number of repeated injections.
Математична модель напівпровідникового перетворювача АС-DC
Authors: Lyshuk V. , Yevsiuk М. , Prystupa S. , Selepyna Y. , Yakymchuk N. 
Published: July 2022

У статті запропоновано математичну модель напівпровідникового перетворювача АС-DС, рівняння електромагнітного стану якого записані в нормальній формі Коші. Як відомо, такі диференціальні рівняння суттєво спрощують алгоритми інтегрування під час дослідження перехідних станів пристрою. Запропонована модель мостового випрямляча дасть змогу правильно проектувати та експлуатувати такі пристрої. Результати комп’ютерної симуляції приведені графічними залежностями.
HUBUNGAN TINGKAT PENGETAHUAN LANSIA DENGAN TINGKAT KEMANDIRIAN ADL (ACTIVITY DAILY LIVING) PENANGANAN COMORBID COVID-19 DI PUSKESMAS KENJERAN SURABAYA.
Authors: Sya'diyah Hisayatus , Mutyah Diyan , Mayasari Ayu Citra , Candra Kirana Sukma Ayu , Gufron Ali 
Published: July 2022

Latar Belakang: Covid-19 menyerang semua umur tanpa terkecuali, virus corona lebih berbahaya jika menyerang orang lanjut usia yang membawa penyakit bawaan seperti diabetes mellitus, penderita asma kronis, dan hipertensi. Kurangnya pengetahuan lansia yang baik dalam menghadapi penyakit penyerta seperti hipertensi dapat menyebabkan lansia berisiko tinggi tertular covid 19. Pengetahuan diperlukan agar lansia terlindungi dari paparan virus, peran dalam keluarga sangat diperlukan. juga penting untuk menjaga salah satu keluarga dari tertular covid 19.
Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan lansia dengan tingkat kemandirian ADL (Activity Daily Living) dalam penanganan komorbiditas Covid-19 di Puskesmas Kenjeran Surabaya.
Metode: Desain penelitian ini adalah analitik korelasional dengan pendekatan cross sectional. Sampel menggunakan Simple Random Sampling sebanyak 70 lansia di Puskesmas Kenjeran Surabaya. Variabel bebas dalam penelitian ini adalah tingkat pengetahuan yang diukur dengan instrumen angket pengetahuan menurut Arikunto. Variabel terikat dalam penelitian ini adalah tingkat kemandirian yang diukur dengan instrumen angket Barthel's Index. Analisis data menggunakan uji Spearman rho = 0,05
Hasil: Hasil penelitian ini menunjukkan bahwa hasil penelitian terhadap 70 responden memiliki hubungan antara tingkat pengetahuan lansia dengan tingkat kemandirian dalam penanganan komorbid covid 19 di Puskesmas Kenjeran Surabaya dengan = 0,032 (? = <0,05)
Kesimpulan: Implikasi dari penelitian ini adalah tingkat pengetahuan lansia berperan penting dalam meningkatkan tingkat kemandirian lansia dalam menangani komorbiditas covid-19, sehingga memerlukan perhatian dan penanganan dini oleh perawat, keluarga dan petugas kesehatan lainnya

Kata kunci: Lansia, pengetahuan, tingkat kemandirian
STUDI FENOMENOLOGI PENGALAMAN LANSIA DENGAN DEMENSIA MENGIKUTI CST (COGNITIVE STIMULATION THERAPY) DI LKS-LU PANGESTI LAWANG
Authors: Sipollo Berliany Venny 
Published: July 2022

ABSTRAK
Latar belakang: Demensia mempengaruhi setiap lansia dengan cara yang berbeda tergantung pada dampak penyakit dan kepribadian lansia sebelum jatuh sakit. Tujuan: Penelitian kualitatif ini bertujuan untuk mengeksplorasi pengalaman lansia mengikuti Terapi Stimulasi Kognitif atau Cognitive Stimulation Therapy di LKS-LU Pangesti Lawang. Metode: Tehnik pengumpulan data dalam penelitian menggunakan wawancara mendalam (in depth interview) menggunakan pedoman wawancara semi terstruktur. Jumlah sampel 27 lansia yang mendapatkan Terapi Stimulasi Kognitif (CST) tiga kali per minggu selama 5 minggu. Hasil: Hasil wawancara pengalaman lansia setelah mengikuti Terapi Stimulasi Kognitif (CST) didapatkan 4 tema sebagai berikut: 1. Daya ingat meningkat; 2. Diskusi bersama; 3. Bahagia; 4. Meningkatkan semangat dan motivasi. Kesimpulan: Terapi Stimulasi Kognitif meningkatkan daya ingat pada lansia yang mengalami gangguan jiwa. Perawat dan tim perawatan kesehatan dapat menerapkan terapi stimulasi kognitif secara teratur pada lansia.

Kata kunci: Demensia, Lansia, Terapi Stimulasi Kognitif.
Effect of Thickness and Deposition Angle on Optical Transmittance of ZnS/Ag Nanostructures
Authors: Bwayo Edward , Tumps Ireeta Wiston , Mukiibi Dan , Okullo Willy , Okello Dennis , Lugolole Robert 
Published: July 2022

This paper presents the optical transmittance properties of thermally evaporated coatings of ZnS/Ag nanostructures as a function of film thickness and deposition angle designed to mitigate the challenges of indoor heating and their effects on low temperature storage facilities. The nanostructures were deposited on glass by varying the film thickness and deposition angle of both silver and zinc sulphide nanofilms at a pressure of 2.5×10-5 mBars in the diffusion pump microprocessor vacuum coater (Edwards AUTO 306). The optical transmittance of the coatings was measured at normal incidence in the wavelength range of 250-2500 nm of the incident electromagnetic radiation. Spectral studies showed that the transmittance decreased with increase in the film thickness of the ZnS/Ag nanostructures and the optical transmittance increased with increase in deposition angle of zinc sulphide in the infrared region. The transmittance of (4 nm)ZnS/Ag, (7 nm)ZnS/Ag, (10 nm)ZnS/Ag and (15 nm)ZnS/Ag samples deposited at normal angle in the visible region had peaks at 61.7%, 66.3%, 54.9%, and 18.0% respectively. The transmittance of the nanostructures increased with the increase in deposition angle of silver nanoparticles. Thus optical transmittance measured at 1800 nm wavelengths for ZnS(0o)/Ag(0o), ZnS(0o)/Ag(30o) and ZnS(0o)/Ag(60o) were 2.8%, 21.7% and 22.1% respectively. The coating of ZnS at high deposition angle decreased transmittance in the visible wavelength. The transmittance peak values in the visible region measured up to 51.1%, 53.5%, and 45.1% for (4 nm)ZnS(0o)/Ag(0o) and (4 nm)ZnS(0o)/Ag(30o) and (4 nm)ZnS(0o)/Ag(60o) samples respectively. However, increase in deposition angle of (10nm)ZnS/Ag nanostructures measured at 1000 nm; ZnS(0o)/Ag(30o), ZnS(30o)/Ag(30o) and ZnS(60o)/Ag(30o) increased transmittance in the infrared wavelengths from 9% to 12% and 34% respectively. Therefore, to increase transmittance in the visible region, the Zinc sulphide nanoparticles should be coated on silver at low deposition angles.