bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value creation in circular economy business for sustainability: A stakeholder relationship perspective
Authors: Tapaninaho Riikka , Heikkinen Anna 
Published: January 2022

AbstractA circular economy (CE) requires companies to rethink their value creation and stakeholder relationships. While value creation in a CE business is typically understood from a company‐centric perspective, this article utilises stakeholder theory to conceptualise value creation as a relational, systemic activity involving multiple stakeholder relationships. We conduct a case study of the CE business development of a Finnish energy company and offer novel insights by identifying five joint value creation activities: sharing the CE story, co‐constructing knowledge for political decision‐making, developing the industry, creating local CE ecosystems and refining the business model. Additionally, we define the concept of multidimensional value, which acknowledges multifaceted, subjective stakeholder value expectations and enables the engagement of stakeholders in joint value creation activities. We conclude that the stakeholder relationship perspective on CE business value creation allows for the creation of the synergy necessary to advance CE business and sustainability.
Why are individuals over age 60 still committed as sexually violent persons?
Authors: Kahn Rachel E. , Ambroziak Gina , Mundt James C. , Keiser Kerry L. , Thornton David 
Published: January 2022

AbstractCivilly committed sexually violent persons (SVPs) are a select group of individuals designated as high risk for future sexual violence. Despite risk reduction in older age, SVP programs are seeing aging client populations, with many individuals remaining committed after age 60 (60+). Recent research found a sexual recidivism rate of 7.5% for 60+ individuals released from an SVP civil commitment program. The current paper follows up by examining reasons why individuals remain committed after age 60. It compares SVPs discharged after age 60 to those who are 60+ but remain civilly committed. Results of bivariate analyses reveal older SVPs who remain committed have significantly higher actuarial risk scores and are more likely to be of minority race. Multivariate logistic regression analyses found actuarial risk scores (Static‐99R) predicted continued commitment, after controlling for other relevant variables. Barriers to community reintegration and suggestions for multi‐disciplinary case management for older SVPs are discussed.
Design, Synthesis, and Biological Activity of Chalcone Analogs Containing 4‐Phenylquinolin and Benzohydrazide
Authors: Tan Qiu‐Wan , He Li‐Ya , Zhang Shan‐Shan , He Zhi‐Wen , Liu Wei‐Hua , Zhang Li , Guan Li‐Ping , Wang Si‐Hong 
Published: January 2022

AbstractA series of chalcone derivatives (3a–3m) containing 4‐phenylquinoline and benzohydrazide were designed and synthesized, and their anti‐inflammatory, analgesic, and antidepressant activities were evaluated. Using the classic antidepressant model, except for compounds 3a and 3d, 11 compounds all showed certain antidepressant activity at a dose of 100 mg/kg, among which compounds 3f, 3h, and 3m showed good antidepressant activity (inhibition rate, respectively 63.0 %, 73.2 %, and 76.4 %), which was equivalent to the positive control fluoxetine (inhibition rate of 70.0 %). Secondly, the inhibitory activity of these compounds on mouse MAOA was evaluated. At 10 mM, compounds 3f and 3j showed a certain selective inhibitory effect on mouse MAOA, while compounds 3b, 3d, 3g, 3i, and 3m had a good inhibitory effect on mouse MAOA (inhibition rate is 42.3–71.4 %). The mouse ear edema model was used to evaluate the anti‐inflammatory activity of compounds 3a–3m. At 30 mg/kg, compounds 3b, 3c, 3e, 3f, 3g, and 3m showed certain anti‐inflammatory effects (inhibition rate of 51.5–99.9 %), which was equivalent to the positive control indomethacin (inhibition rate of 69.7 %). Results of the acetic acid‐induced abdominal writhing test showed that, at 30 mg/kg, excepted for compounds 3a, 3b and 3d, all the other 10 compounds can show certain analgesic activity (inhibition rate 67–99.9 %). The use of Auto dock Vina (simina) to simulate molecular target docking shows that the development of quinoline and benzohydrazide groups is of great significance to MAOA inhibitors.
A New Lignan and C(6)‐Oxygenated Flavonoids from the Inflorescence of Ambrosia artemisiifolia
Authors: Zeng Zhi , Cheng Dan , Lai Meng‐Meng , He Hua‐Liang , Qiu Lin , Xue Jin , Li You‐Zhi , Ding Wen‐Bing 
Published: January 2022

AbstractA new lignan (4,4′,5′‐trihydroxy‐5,3′‐dimethoxy‐3‐O‐9′,2‐(7′R)‐lignan, 1) and eight C(6)‐oxygenated flavonoids (2–9), including a newly identified flavonoid (7,3’,4’‐trihydroxy‐3,5,6‐trimethoxyflavone, 2), were isolated from the inflorescence of Ambrosia artemisiifolia L. The structures of these isolates were determined using extensive spectroscopic analyses and comparison with data previously reported in the literature. The absolute configuration of compound 1 was established using electronic circular dichroism (ECD) spectrum. All the flavonoids (2–9) showed inhibitory effects on LPS‐induced NO production in RAW264.7 cells, with the inhibition rate ranging from 24.51 % to 69.82 % at 50 μM. The in vitro cytotoxicity study showed that compounds 3–8 have a 60 % inhibition rate against SMMC‐7721 at a concentration of 40 μM, while compounds 5 and 8 also exhibited inhibitory activity against HL‐60 at 40 μM with the inhibition rate of 83.36 % and 52.01 %, respectively.
Engineering CYP153AM.aq to Oxyfunctionalize its Inhibitor Dodecylamine Using a LC/MS Based Rapid Flow Analysis Screening
Authors: Rapp Lea R. , Marques Sérgio M. , Nebel Bernd , Damborsky Jiri , Hauer Bernhard 
Published: January 2022

AbstractThe catalytic space of the P450 monooxygenase CYP153AM.aq was opened from a terminal (ω‐) fatty acid hydroxylase to a catalyst capable of performing ω‐hydroxylation of dodecylamine, which is a potent inhibitor for the wild‐type enzyme. A simple screening method named Rapid‐flow Analysis of Product Peaks (RAPP) was established and applied to measure saturation libraries directly from a 96‐deepwell plate in 36 seconds per sample. The obtained variants are less inhibited by the amine, although concurrently show less affinity towards the acid. Molecular modelling and molecular dynamics simulations showed significant effects of the mutations on the substrate tunnel architectures.
Towards a Local In situ X‐ray Nano Computed Tomography under Realistic Cycling Conditions for Battery Research
Authors: Su Zeliang , Nguyen Tuan‐Tu , Le Bourlot Christophe , Cadiou François , Jamali Arash , De Andrade Vincent , Franco Alejandro A. , Demortière Arnaud 
Published: January 2022

AbstractPerforming high resolution 3D imaging with transmission X‐ray microscopy (TXM) in an in situ battery system is extremely challenging. We show herein a method to conduct an in situ nano‐X ray Computed Tomography (nano‐XCT) experiment assisted by the in‐line phase contrast technique for low Z elements in batteries. A carbon‐based O2‐cathode of Li‐O2 battery was used for this investigation and the time‐resolved 3D volumes were obtained and successfully reconstructed. Our approach is to perform a nano‐XCT by zooming directly into a laser‐shaped area not larger than 50 μm in an in‐house in situ cell. The rotation axis of the tomography of this cell being parallel to the plan of the electrode, a specific method of preparing the electrode by laser is required. This method is essential in this approach, which allows to minimize the dead angles, align the beam and adjust the focus plan. We have demonstrated in situ observation of the difficult light species, lithium peroxide, in a lithium‐oxygen battery. The time‐resolved 3D volumes obtained showed a force pushing the analyzed area out of the field of view. This is due to the thickening of the lithium foil during the electrochemical process. Although X‐ray Computed‐Tomography (XCT) is often considered non‐invasive and beneficial for the development of an in situ experiment for battery research, here we discuss the effect of the focused beam at the nanoscale with a focusing X‐ray beam. The current contribution opens possibilities of characterization of battery materials by local in situ nano‐XCT under realistic cycling conditions.
Photoresponsive Metal‐Organic Frameworks: Tailorable Platforms of Photoswitches for Advanced Functions
Authors: Zhang Xiayu , Yu Tao , Au Vonika Ka‐Man 
Published: January 2022

AbstractStimuli‐responsive metal‐organic frameworks (MOFs) have attracted great interest in a diverse range of applications due to their abilities to change attributes under external stimuli. As a ubiquitous stimulus, light can be remotely controlled and quickly switched. Hence, the exploration of photoresponsive materials has attracted widespread interest. In particular, photoresponsive MOFs are usually formed by inserting photoswitchable linkers of different properties within the MOF backbone. Under the action of light, some physical and/or chemical changes will occur, resulting in a series of structural and morphological changes, in turn producing specific functions in different MOF materials. In this review, we will highlight some representative examples to demonstrate the recent advances in the development of photoresponsive MOF‐based materials. The main types of molecular photoswitches, their properties and the main applications of photoresponsive MOFs will also be covered, followed by a discussion on the future development of the field.
BRD4‐IRF1 axis regulates chemoradiotherapy‐induced PD‐L1 expression and immune evasion in non‐small cell lung cancer
Authors: Wang Jian , Xu Yingzhuo , Rao Xinrui , Zhang Ruiguang , Tang Jing , Zhang Dan , Jie Xiaohua , Zhu Kuikui , Wang Xu , Xu Yunhong , Zhang Sheng , Dong Xiaorong , Zhang Tao , Yang Kunyu , Xu Shuangbing , Meng Rui , Wu Gang 
Published: January 2022

BackgroundChemoradiotherapy‐induced PD‐L1 upregulation leads to therapeutic resistance and treatment failure. The PD‐1/PD‐L1 blocking antibodies sensitize cancers to chemoradiotherapy by blocking extracellular PD‐1 and PD‐L1 binding without affecting the oncogenic function of intracellular PD‐L1. Reversing the chemoradiation‐induced PD‐L1 expression could provide a new strategy to achieve a greater anti‐tumour effect of chemoradiotherapy. Here, we aimed to identify candidate small molecular inhibitors that might boost the anti‐tumour immunity of chemoradiotherapy by decreasing treatment‐induced PD‐L1 expression in non‐small cell lung cancer (NSCLC).MethodsA drug array was used to recognize compounds that can suppress the cisplatin‐induced and radiation‐induced PD‐L1 expression in NSCLC via the flow cytometry‐based assay. We examined whether and how targeting bromodomain containing 4 (BRD4) inhibits chemoradiation‐induced PD‐L1 expression and evaluated the effect of BRD4 inhibition and chemoradiation combination in vivo.ResultsBRD4 inhibitors JQ1 and ARV‐771 were identified as the most promising drugs both in the cisplatin and radiation screening projects in two NSCLC cell lines. Targeting BRD4 was supposed to block chemoradiotherapy inducible PD‐L1 expression by disrupting the recruitment of BRD4‐IRF1 complex to PD‐L1 promoter. A positive correlation between BRD4 and PD‐L1 expression was observed in human NSCLC tissues. Moreover, BRD4 inhibition synergized with chemoradiotherapy and PD‐1 blockade to show a robust anti‐tumour immunity dependent on CD8+ T cell through limiting chemoradiation‐induced tumour cell surface PD‐L1 upregulation in vivo. Notably, the BRD4‐targeted combinatory treatments did not show increased toxicities.ConclusionThe data showed that BRD4‐targeted therapy synergized with chemoradiotherapy and anti‐PD‐1 antibody by boosting anti‐tumour immunity in NSCLC.
Habitat use and foraging parameters of breeding Skylarks indicate no seasonal decrease in food availability in heterogeneous farmland
Authors: Püttmanns Manuel , Böttges Laura , Filla Tim , Lehmann Franziska , Martens Annika Sophie , Siegel Friederike , Sippel Anna , von Bassi Marlene , Balkenhol Niko , Waltert Matthias , Gottschalk Eckhard 
Published: January 2022

AbstractReduced food availability during chick raising is a major driver of farmland bird declines. For the Eurasian Skylark (Alauda arvensis), food availability is determined by various factors (i.e., arthropod abundance/diversity, accessibility of the vegetation, distance to foraging sites). In modern farmland, it is supposed to decrease over the breeding season due to less penetrable vegetation. We explored foraging habitat selection by chick‐raising Skylarks with a focus on the seasonal dynamics of habitat use and food availability. We investigated (i) habitat selection concerning prey biomass/diversity, vegetation cover, and distance to foraging sites, (ii) the overall and seasonal habitat use, and (iii) seasonal developments of foraging parameters (e.g., the feeding frequency) as indicators of food availability. We collected data on foraging habitats and foraging parameters of chick‐raising Skylark pairs at 51 nests from a Central European population in 2018 and 2019. Prey biomass/diversity and vegetation cover were measured for all habitats around 42 of these nests. As revealed by multivariate and compositional analyses, Skylarks mainly selected foraging habitats based on the proximity to nests. The most frequent habitats within home ranges could not be ranked according to an overall importance for foraging and their use partially changed over time. The feeding frequency increased throughout the breeding season, while other foraging parameters did not show significant changes. In contrast to our expectations, our data indicated therefore an increase, not a decrease in food availability in the late breeding season. This also implies that the way in which Skylarks used habitats was constantly suitable to raise offspring. We interpret this to be a consequence of the heterogeneous farmland composition of the study area that enabled Skylarks to establish a diverse home range and to benefit from the synergetic effects of neighboring habitat types. Thus, our findings provide support for the high importance of crop diversity in Skylark conservation.
Greater than the sum of your parts: Nonlethal stable isotope sampling methods in spiders
Authors: Marker Jeffery , Lafage Denis , Bergman Eva , Bowes Rachel E. 
Published: January 2022

AbstractAs top consumers and generalist predators, spiders are ideal organisms to study food webs and complex ecological functions using stable isotopes. Most researchers use whole‐body samples to analyze stable isotope ratios in spiders. Spiders can regrow lost legs and produce multiple molts during a life cycle, and nonlethal sampling utilizing legs and molts may provide a useful alternative to whole‐body sampling especially in larger bodied or threatened species. Furthermore, removing spider abdomens and thus leftover prey in the gut contents may provide a more accurate isotopic value. We tested the hypothesis that the δ15N, δ13C, or δ2H isotopic values in spider legs are reliable proxies for spider prosomas, abdomens, or whole bodies. We used laboratory‐reared large‐bodied spiders (Pterinochilus murinus) and field‐collected Lycosidae to compare lethal and nonlethal tissue isotopic values. We found that nonlethal samples of spider legs and molts are acceptable alternatives to lethal whole‐body samples to determine δ13C and δ15N stable isotope signatures. Nonlethal samples are not suitable proxies for whole‐body samples to determine δ2H isotopic values. Using nonlethal leg or molts samples in stable isotope investigations of spiders will allow researchers to promote conservation efforts and study threatened species while ensuring accurate and repeatable results.
Dietary composition and fatty acid content of giant salmonflies (Pteronarcys californica) in two Rocky Mountain rivers
Authors: Albertson Lindsey K. , Briggs Michelle A. , Maguire Zachary , Swart Sophia , Cross Wyatt F. , Twining Cornelia W. , Wesner Jeff S. , Baxter Colden V. , Walters David M. 
Published: January 2022

AbstractMany aquatic invertebrates are declining or facing extinction from stressors that compromise physiology, resource consumption, reproduction, and phenology. However, the influence of these common stressors specifically on consumer–resource interactions for aquatic invertebrate consumers is only beginning to be understood. We conducted a field study to investigate Pteronarcys californica (i.e., the “giant salmonfly”), a large‐bodied insect that is ecologically and culturally significant to rivers throughout the western United States. We sampled gut contents and polyunsaturated fatty acid composition of salmonflies to compare resource consumption across river (Madison or Gallatin, Montana), sex (male or female), and habitat (rock or woody debris). We found that allochthonous detritus comprised the majority of salmonfly diets in the Gallatin and Madison Rivers, making up 68% of the gut contents on average, followed by amorphous detritus, diatoms, and filamentous algae. Diets showed little variation across river, sex, or length. Minor differences in diets were detected by habitat type, with a higher proportion of diatoms in the diets of salmonflies collected from rocky habitat compared to woody debris. Fatty acid composition generally supported the results of gut content analysis but highlighted the importance of primary producers. The presence of eicosapentaenoic acid (20:5n‐3) and alpha linolenic acid (18:3n‐3) indicated consumption of diatoms and filamentous green algae, respectively. Our research underscores the importance of a healthy riparian zone that provides allochthonous detritus for invertebrate nutrition as well as the role of algae as an important source of fatty acids.
Seed bank bias: Differential tracking of functional traits in the seed bank and vegetation across a gradient
Authors: Larson Julie E. , Suding Katharine N. 
Published: January 2022

AbstractA goal in trait‐based ecology is to understand and predict plant community responses to environmental change; however, diversity stored within seed banks that may expand or limit these responses is typically overlooked. If seed banks store attributes that are more advantageous or vulnerable under future conditions, they could impact community adaptability to change and disturbance. We explored compositional differences between seed banks and vegetation (i.e., seed bank bias) across a 12‐site gradient of increasingly higher and older soil terraces, asking: How do seed banks contribute to taxonomic and functional composition, and what do shifts in seed bank biases along the gradient (i.e., tracking) reveal about the processes driving seed bank variation and its implications for community adaptability? Across the gradient, seed banks stored distinct pools of species that added to species richness but not functional dispersion. Seed banks were generally biased toward short‐life histories and “fast” species with small seeds, thinner and more acquisitive roots, and lower root biomass allocation; however, trait means in the seed bank and vegetation sometimes shifted along the gradient, amplifying or reversing these biases. For example, species with higher specific leaf area (tied to rapid resource acquisition) tended to dominate vegetation on lower soil terraces, but were more common in the seed bank on higher terraces—at least when patterns were weighted by species' relative abundances. Although seed banks were generally characterized by “fast” attributes, observed shifts in seed bank biases across the gradient—particularly in leaf traits—demonstrate that environment can impact stored diversity and, consequently, our expectations for future vegetative turnover. The seed bank bias patterns that we characterized could be the result of many potential processes, including environment‐ or trait‐driven variation in seed bank inputs (seed production, dispersal) or losses (seed desiccation, germination), and may have important implications for a system's adaptive capacity. Only by integrating seed banks into the functional ecology agenda will we be able to unpack these processes and use seed banks more effectively in both prediction and ecosystem management.
Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology
Authors: Piepoli Massimo F. , Adamo Marianna , Barison Andrea , Bestetti Reinaldo B. , Biegus Jan , Böhm Michael , Butler Javed , Carapetis Jonathan , Ceconi Claudio , Chioncel Ovidiu , Coats Andrew , Crespo‐Leiro Maria G. , de Simone Giovanni , Drexel Heinz , Emdin Michele , Farmakis Dimitros , Halle Martin , Heymans Stephane , Jaarsma Tiny , Jankowska Ewa , Lainscak Mitja , Lam Carolyn S.P. , Løchen Maja‐Lisa , Lopatin Yuri , Maggioni Aldo , Matrone Benedetta , Metra Marco , Noonan Katharine , Pina Ileana , Prescott Eva , Rosano Giuseppe , Seferovic Petar M. , Sliwa Karen , Stewart Simon , Uijl Alicia , Vaartjes Ilonca , Vermeulen Roel , Monique Verschuren W. M. , Volterrani Maurizio , von Haehling Stephan , Hoes Arno 
Published: January 2022

AbstractThe heart failure epidemic is growing and its prevention, in order to reduce associated hospital readmission rates and its clinical and economic burden, is a key issue in modern cardiovascular medicine. The present position paper aims to provide practical evidence‐based information to support the implementation of effective preventive measures. After reviewing the most common risk factors, an overview of the population attributable risks in different continents is presented, to identify potentially effective opportunities for prevention and to inform preventive strategies. Finally, potential interventions that have been proposed and have been shown to be effective in preventing heart failure are listed.
European Society of Cardiology quality indicators for the care and outcomes of adults with heart failure. Developed by the Working Group for Heart Failure Quality Indicators in collaboration with the Heart Failure Association of the European Society of Cardiology
Authors: Aktaa Suleman , Polovina Marija , Rosano Giuseppe , Abdin Amr , Anguita Manuel , Lainscak Mitja , Lund Lars H. , McDonagh Theresa , Metra Marco , Mindham Richard , Piepoli Massimo , Störk Stefan , Tokmakova Mariya P. , Seferović Petar , Gale Chris P. , Coats Andrew J.S. 
Published: January 2022

AbstractAimsTo develop a suite of quality indicators (QIs) for the evaluation of the quality of care for adults with heart failure (HF).Methods and resultsWe followed the ESC methodology for QI development, which involved (i) the identification of the key domains of care for the management of HF by constructing a conceptual framework of HF care, (ii) the development of candidate QIs by conducting a systematic review of the literature, (iii) the selection of the final set of QIs using a modified Delphi method, and (iv) the evaluation of the feasibility of the developed QIs. The Working Group comprised experts in HF management including Task Force members of the 2021 European Society of Cardiology (ESC) Clinical Practice Guidelines for HF, members of the Heart Failure Association (HFA), Quality Indicator Committee and a patient representative. In total, 12 main and 4 secondary QIs were selected across five domains of care for the management of HF: (1) structural framework, (2) patient assessment, (3) initial treatment, (4) therapy optimization, and (5) assessment of patient health‐related quality of life.ConclusionWe present the ESC HFA QIs for HF, describe their development process and provide the scientific rationale for their selection. The indicators may be used to quantify and improve adherence to guideline‐recommended clinical practice and thus improve patient outcomes.