bluuebunny/crossref_metadata_2025_split huggingface dataset:
First Integrals and Symmetries of Nonholonomic Systems
Authors: Balseiro Paula , Sansonetto Nicola 
Published: March 2022

AbstractIn nonholonomic mechanics, the presence of constraints in the velocities breaks the well-understood link between symmetries and first integrals of holonomic systems, expressed by Noether’s Theorem. However, there is a known special class of first integrals of nonholonomic systems generated by vector fields tangential to the group orbits, called horizontal gauge momenta, that suggests that some version of this link still holds. In this paper we prove that, under certain conditions on the symmetry group and the system, the (nonholonomic) momentum map is conserved along the nonholonomic dynamics, thus extending Noether’s Theorem to the nonholonomic framework. Our analysis leads to a constructive method, with fundamental consequences to the integrability of some nonholonomic systems as well as their hamiltonization. We apply our results to three paradigmatic examples: the snakeboard, a solid of revolution rolling without sliding on a plane, and a heavy homogeneous ball that rolls without sliding inside a convex surface of revolution.
Determination of the protein content of complex samples by aromatic amino acid analysis, liquid chromatography-UV absorbance, and colorimetry
Authors: Reinmuth-Selzle Kathrin , Tchipilov Teodor , Backes Anna T. , Tscheuschner Georg , Tang Kai , Ziegler Kira , Lucas Kurt , Pöschl Ulrich , Fröhlich-Nowoisky Janine , Weller Michael G. 
Published: March 2022

AbstractFast and accurate determination of the protein content of a sample is an important and non-trivial task of many biochemical, biomedical, food chemical, pharmaceutical, and environmental research activities. Different methods of total protein determination are used for a wide range of proteins with highly variable properties in complex matrices. These methods usually work reasonably well for proteins under controlled conditions, but the results for non-standard and complex samples are often questionable. Here, we compare new and well-established methods, including traditional amino acid analysis (AAA), aromatic amino acid analysis (AAAA) based on the amino acids phenylalanine and tyrosine, reversed-phase liquid chromatography of intact proteins with UV absorbance measurements at 220 and 280 nm (LC-220, LC-280), and colorimetric assays like Coomassie Blue G-250 dye-binding assay (Bradford) and bicinchoninic acid (BCA) assay. We investigated different samples, including proteins with challenging properties, chemical modifications, mixtures, and complex matrices like air particulate matter and pollen extracts. All methods yielded accurate and precise results for the protein and matrix used for calibration. AAA, AAAA with fluorescence detection, and the LC-220 method yielded robust results even under more challenging conditions (variable analytes and matrices). These methods turned out to be well-suited for reliable determination of the protein content in a wide range of samples, such as air particulate matter and pollen.
TAVI in patients with low-flow low-gradient aortic stenosis–short-term and long-term outcomes
Authors: Steffen Julius , Reißig Nikolas , Andreae David , Beckmann Markus , Haum Magda , Fischer Julius , Theiss Hans , Braun Daniel , Orban Martin , Rizas Konstantinos , Sadoni Sebastian , Näbauer Michael , Peterss Sven , Hausleiter Jörg , Massberg Steffen , Deseive Simon 
Published: March 2022

Abstract
Objectives
The study objective was to characterize different groups of low-flow low-gradient (LFLG) aortic stenosis (AS) and determine short-term outcomes and long-term mortality according to Valve Academic Research Consortium-3 (VARC-3) endpoint definitions.

Background
Characteristics and outcomes of patients with LFLG AS undergoing transcatheter aortic valve implantation (TAVI) are poorly understood.

Methods
All patients undergoing TAVI at our center between 2013 and 2019 were screened. Patients were divided into three groups according to mean pressure gradient (dPmean), ejection fraction (LVEF), and stroke volume index (SVi): high gradient (HG) AS (dPmean ≥ 40 mmHg), classical LFLG (cLFLG) AS (dPmean < 40 mmHg, LVEF < 50%), and paradoxical LFLG (pLFLG) AS (dPmean < 40 mmHg, LVEF ≥ 50%, SVi ≤ 35 ml/m2).

Results
We included 1776 patients (956 HG, 447 cLFLG, and 373 pLFLG patients). Most baseline characteristics differed significantly. Median Society of Thoracic Surgeons (STS) score was highest in cLFLG, followed by pLFLG and HG patients (5.0, 3.9 and 3.0, respectively, p < 0.01). Compared to HG patients, odds ratios for the short-term VARC-3 composite endpoints, technical failure (cLFLG, 0.76 [95% confidence interval, 0.40–1.36], pLFLG, 1.37 [0.79–2.31]) and device failure (cLFLG, 1.06 [0.74–1.49], pLFLG, 0.97 [0.66–1.41]) were similar, without relevant differences within LFLG patients. NYHA classes improved equally in all groups. Compared to HG, LFLG patients had a higher 3-year all-cause mortality (STS score-adjusted hazard ratios, cLFLG 2.16 [1.77–2.64], pLFLG 1.53 [1.22–193]), as well as cardiovascular mortality (cLFLG, 2.88 [2.15–3.84], pLFLG, 2.08 [1.50–2.87]).

Conclusions
While 3-year mortality remains high after TAVI in LFLG compared to HG patients, symptoms improve in all subsets after TAVI.

Graphical abstract
Quantitative comparison of the mean–return-time phase and the stochastic asymptotic phase for noisy oscillators
Authors: Pérez-Cervera Alberto , Lindner Benjamin , Thomas Peter J. 
Published: March 2022

AbstractSeminal work by A. Winfree and J. Guckenheimer showed that a deterministic phase variable can be defined either in terms of Poincaré sections or in terms of the asymptotic (long-time) behaviour of trajectories approaching a stable limit cycle. However, this equivalence between the deterministic notions of phase is broken in the presence of noise. Different notions of phase reduction for a stochastic oscillator can be defined either in terms of mean–return-time sections or as the argument of the slowest decaying complex eigenfunction of the Kolmogorov backwards operator. Although both notions of phase enjoy a solid theoretical foundation, their relationship remains unexplored. Here, we quantitatively compare both notions of stochastic phase. We derive an expression relating both notions of phase and use it to discuss differences (and similarities) between both definitions of stochastic phase for (i) a spiral sink motivated by stochastic models for electroencephalograms, (ii) noisy limit-cycle systems-neuroscience models, and (iii) a stochastic heteroclinic oscillator inspired by a simple motor-control system.
A meta-analysis of the long-term outcomes following surgery or endoscopic therapy for chronic pancreatitis
Authors: Hughes Daniel Ll , Hughes Ioan , Silva Michael A. 
Published: March 2022

Abstract
Purpose
Refractory abdominal pain is a cardinal symptom of chronic pancreatitis (CP). Management strategies revolve around pain mitigation and resolution. Emerging evidence from observational studies highlights that surgery may result in superior pain relief when compared to endoscopic therapy; however, its impact on long-term quality of life or functional outcome has yet to be determined.

Methods
A search through MEDLINE, PubMed and Web of Science was performed for RCTs that compared endoscopic treatment with surgery for the management of CP. The main outcome measure was the impact on pain control. Secondary outcome measures were the effect on quality of life and the incidence rate of new onset exocrine and endocrine failure. Data was pooled for analysis using either an odds ratio (OR) or mean difference (MD) with a random effects model.

Results
Three RCTs were included with a total of 267 patients. Meta-analysis demonstrated that operative treatment was associated with a significantly higher rate of complete pain control (37%) when compared to endoscopic therapy (17%) [OR (95% confidence interval (CI)) 2.79 (1.53–5.08), p = 0.0008]. No difference was noted in the incidence of new onset endocrine or exocrine failure between treatment strategies.

Conclusion
Surgical management of CP results in a greater extent of complete pain relief during long-term follow-up. Further research is required to evaluate the impact of the time interval between diagnosis and intervention on exocrine function, combined with the effect of early up-front islet auto-transplantation in order to determine whether long-term endocrine function can be achieved.
High CO2 content in magmas of the explosive andesitic Enco eruption of Mocho-Choshuenco volcano (Chile)
Authors: Feignon Jean-Guillaume , Cluzel Nicolas , Schiavi Federica , Moune Séverine , Roche Olivier , Clavero Jorge , Schiano Pierre , Auxerre Marion 
Published: March 2022

Abstract
Mocho-Choshuenco volcano has produced several highly explosive eruptions during its history, which make it one of the most hazardous volcanoes in the southern volcanic zone of Chile, although it is still relatively little studied to date. We present a geochemical study of the products of the sub-Plinian, andesitic, Enco eruption that occurred about 1600 years ago. We determined the major and trace elements compositions, as well as the volatile (H2O, CO2, Cl, and S) contents of melt inclusions trapped in minerals (olivine, plagioclase, and pyroxene) using electron microprobe, ion microprobe (SIMS), and 3D confocal Raman mapping. Though the whole-rock composition of the Enco magma is andesitic (60.2 ± 1.1 wt.% SiO2), the melt inclusions have SiO2 contents ranging from 50.3 to 67.3 wt.%, following the magmatic series of Mocho-Choshuenco, and the compositions of the most mafic melt inclusions are close to those of the most mafic erupted magmas. Geochemical modeling indicates that mixing occurred between a mafic magma and an andesitic-to-dacitic magma. Glass analysis revealed typical parental arc magma values for H2O (2.6–3.8 wt.%), S (116–1936 ppm), and Cl (620–1439 ppm). However, CO2 contents are very high in some melt inclusions with concentrations above 4000 ppm (measured in the glass), suggesting trapping depths >  ~ 17–22 km. Presence of solid carbonates inside inclusion-hosted bubbles clearly indicates that the CO2 contents measured in the glass phase were minimum values. We conclude that a CO2-rich basaltic magma ascended and mixed with a shallower andesitic magma. The magma cooled and exsolved high amounts of CO2, which may have dramatically increased the pressure and triggered the highly explosive Enco eruption.
PCB motors for sub-fractional HP auxiliary fan drives: a feasibility study
Authors: Auer David , Leitner Stefan , Muetze Annette 
Published: March 2022

AbstractThis paper investigates the use of PCB motors for sub-fractional HP auxiliary fan drives. First, the basic idea of PCB motors as well as the main advantages and disadvantages are discussed, followed by the description of the design process for a PCB motor for a small automotive fan application. Three different stator designs have been implemented, each on a 4-layer PCB. Finally, the paper gives an overview of the measurements performed and the results obtained for the prototypes of the manufactured PCB motors and suggests design improvements.
Intercostal lung herniation; a rare complication after mini-transthoracic approach (TTA) for thoracic disc herniation. Two case reports and review of literature
Authors: De Vries Suzanne E N , Arts Mark P , Van Huijstee Pieter J. 
Published: March 2022

Abstract
Background
Lung herniation is a rare condition, most often due to thoracic injury, but has also been described as a complication following cardiothoracic surgery. Here, we report two cases of post-surgical lung herniation following a neurosurgical mini-transthoracic (mini-TTA) for treatment of thoracic herniated discs. With this report we aim to make surgeons aware of this rare complication, review existing literature on surgical repairs and describe our novel correction technique using video assisted thoracic surgery (VATS) and a combination of mesh covering the muscle defect internally and nitinol rib plates for rib approximation on the outside of the thoracic cavity.

Case description
Patient A was an 85-year-old man who presented with a subcutaneous swelling at the site of surgery following a left sided mini-TTA. Computed tomography (CT) revealed pulmonary tissue herniation. He underwent VATS guided reconstruction. Using two Ventralex meshes covering the defect on the inside and a NiTi-rib H-plate for rib approximation.
Patient B was a 73-year-old woman who developed pulmonary complaints with a soft mass at the surgery site after a left sided mini-TTA. She also underwent VATS guided reconstruction. A large Sempramesh composite mesh and two NiTi-Rib H-plates were used. Recovery was uncomplicated and follow-up revealed no recurrence in both cases.

Conclusion
These cases should make surgeons aware of the possibility of post-surgical development of lung herniation and describe successful correction using a combination of mesh material and NiTi-Rib H-plates through a VATS technique.
A propensity-score matched analysis of ventral-TAPP vs. laparoscopic IPOM for small and mid-sized ventral hernias. Comparison of perioperative data, surgical outcome and cost-effectiveness
Authors: Megas I.-F. , Benzing C. , Winter A. , Raakow J. , Chopra S. , Pratschke J. , Fikatas P. 
Published: March 2022

Abstract
Purpose
Laparoscopic techniques have been used and refined in hernia surgery for several years. The aim of this study was to compare an established method such as laparoscopic intra-peritoneal onlay mesh repair (lap. IPOM) with ventral Transabdominal Preperitoneal Patch Plasty (ventral-TAPP) in abdominal wall hernia repair.

Methods
Patient-related data of 180 laparoscopic ventral hernia repairs between June 2014 and August 2020 were extracted from our prospectively maintained database. Of these patients, 34 underwent ventral-TAPP and 146 lap. IPOM. After excluding hernias with a defect size > 5 cm and obtaining balanced groups with propensity-score matching, a comparative analysis was performed in terms perioperative data, surgical outcomes and cost-effectiveness.

Results
Propensity-score matching suggested 27 patients in each of the two cohorts. The statistical evaluation showed that intake of opiates was significantly higher in the lap. IPOM group compared to ventral-TAPP patients (p = 0.001). The Visual Analogue Scale (VAS) score after lap. IPOM repair was significantly higher at movement (p = 0.008) and at rest (p = 0.023). Also, maximum subjective pain during hospital stay was significantly higher in the lap. IPOM group compared to ventral-TAPP patients (p = 0.004). No hernia recurrence was detected in either group. The material costs of ventral-TAPP procedure (34.37 ± 0.47 €) were significantly lower than those of the lap. IPOM group (742.57 ± 128.44 € p = 0.001). The mean operation time was 65.19 ± 26.43 min in the lap. IPOM group and 58.65 ± 18.43 min in the ventral-TAPP cohort. Additionally, the length of hospital stay in the lap. IPOM cohort was significantly longer (p = 0.043).

Conclusion
Ventral-TAPP procedures represent an alternative technique to lap. IPOM repair to reduce the risk of complications related to intra-peritoneal position of mesh and fixating devices. In addition, our study showed that postoperative pain level, material costs and hospital stay of the ventral-TAPP cohort are significantly lower compared to lap. IPOM patients.
Predictors of unemployment status in people with relapsing multiple sclerosis: a single center experience
Authors: Guerra Tommaso , Pipoli Antonella , Viterbo Rosa Gemma , Manghisi Nicola , Paolicelli Damiano , Iaffaldano Pietro , Di Lorenzo Luigi 
Published: March 2022

Abstract

Background
Multiple sclerosis (MS) is the most common cause of nontraumatic chronic neurological disability affecting young adults during their crucial employment years.

Objectives
To evaluate patients and disease related factors associated to unemployment in a cohort of relapsing–remitting (RR) MS patients.

Methods
We included RRMS patients with a follow-up of at least 1 year. We collected data about years of school education and employment status. Patients underwent a neuropsychological evaluation using the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Demographic and clinical predictors of unemployment were assessed through a multivariable stepwise logistic regression model.

Results
We evaluated 260 consecutive RRMS patients. Employed patients were less frequently female (68.4% vs 83.3%, p = 0.006), less disabled (median Expanded Disability Status Scale (EDSS) score: 2.0 (0–7.0) vs 2.5 (0–7.5), p < 0.001), with more years of school education (mean ± standard deviation (SD), years: 13.74 ± 0.30 vs 10.86 ± 3.47, p < 0.001). Female sex and a higher EDSS score resulted associated with a greater risk of unemployment (OR 3.510, 95% CI 1.654–7.448, p = 0.001; OR 1.366, 95% CI 1.074–1.737, p = 0.011, respectively), whereas a greater number of years of schooling and current disease-modifying therapy exposure resulted protective factors (OR 0.788, 95% CI 0.723–0.858, p < 0,001; OR 0.414, 95% CI 0.217–0.790, p = 0.008, respectively).

Conclusions
Understanding work is pervasively influenced by consequences of MS, we confirmed the impact of demographic, physical, and cognitive factors on employment status in RRMS patients.
On basis constructions in finite element exterior calculus
Authors: Licht Martin W. 
Published: March 2022

AbstractWe give a systematic self-contained exposition of how to construct geometrically decomposed bases and degrees of freedom in finite element exterior calculus. In particular, we elaborate upon a previously overlooked basis for one of the families of finite element spaces, which is of interest for implementations. Moreover, we give details for the construction of isomorphisms and duality pairings between finite element spaces. These structural results show, for example, how to transfer linear dependencies between canonical spanning sets, or how to derive the degrees of freedom.
Core-stability over networks with widespread externalities
Authors: Kóczy László Á. 
Published: March 2022

AbstractThe Covid-19 epidemic highlighted the significance of externalities: contacts with other people affect the chances of getting infected for our entire network. We study endogenous network formation where not only players or pairs but larger coalitions can, cooperatively change the network. We introduce a model for coalitional network stability for networks with widespread externalities. The network function form generalises the partition function form of cooperative games in allowing the network to be taken into account. The recursive core for network function form games generalises the recursive core for such environments. We present two simple examples to illustrate positive and negative externalities. The first is of a favour network and show that the core is nonempty when players must pay transfers to intermediaries; this simple setting also models economic situations such as airline networks. The second models social contacts during an epidemic and finds social bubbles as the solution.
Highly sensitive environmental DNA detection of topmouth gudgeon, Pseudorasbora parva: a comparison of qPCR and microfluidic qdPCR
Authors: Manfrin Chiara , Mirimin Luca , Zanetti Massimo , Pizzul Elisabetta , Giulianini Piero G. , Pallavicini Alberto 
Published: March 2022

AbstractTopmouth gudgeon is a freshwater fish species native to East Asia. Nowadays, P. parva is spread throughout Europe which is of concern because besides being considered one of the worst aquatic Invasive Alien Species (IAS) in Europe it is also a known vector of Spherotecum destruens, the rosette-like parasite lethal to other fish species. The present study describes the development and validation of a new species-specific assay based on hydrolysis probe chemistry to detect P. parva environmental DNA (eDNA) in water samples collected in a northern region of Italy (Friuli Venezia Giulia). Water samples were collected from 55 sites in an area where partial information on the occurrence of the species is available. eDNA was isolated from all samples and the presence of P. parva eDNA was tested by means of qPCR (quantitative PCR) and microfluidic qdPCR (quantitative digital PCR) techniques. Field results for both qPCR and qdPCR were largely in agreement in terms of detection (presence/absence). Thus, we judged the presence/absence by combining the results from the two methods and found that nine sites showed “strong positive” signal of P. parva eDNA (at least 2 positive replicates), 3 showed “suspected” (only 1 positive replicate), and 42 showed “absent”. The current study shows the strong potential of the newly developed eDNA approach to be a valuable addition to the monitoring of the highly invasive topmouth gudgeon in freshwater ecosystems.
Functional traits explain non-native plant species richness and occupancy on northern New Zealand islands
Authors: Mologni Fabio , Bellingham Peter J. , Cameron Ewen K. , Dinh Khoi , Wright Anthony E. , Burns Kevin C. 
Published: March 2022

AbstractPlant functional traits can greatly influence invasion success on islands. However, interrelationships between traits and invasion success are rarely integrated with the island biogeography theory. Here, we explored relations between functional traits and plant distributions to assess which traits are associated with invasion success (i.e. high island occupancy), test whether non-native richness and seed mass of species with distinct growth forms and dispersal modes vary differently with island characteristics (e.g. area, isolation, exposure to ocean-borne disturbances, distance from the nearest urban area, and whether islands were managed for conservation), and whether results differ from native species. We assembled a database of 264 northern New Zealand offshore islands, amalgamating species lists from field surveys and previously published data, and comprising 822 native and 855 non-native species. Non-native graminoids occurred on islands more frequently than forbs and woody species, and long-distance dispersal modes (wind, animal, unspecialized) more than species with short-distance dispersal modes. Most differences among trait categories of non-native species were associated with human-related variables (i.e. distance from the nearest urban area, and whether islands were conservation areas). Non-native plant species with high island occupancy were less commonly associated with human-related variables than non-native species with low island occupancy. Instead, they were more similar in their distributional patterns to native species within the same trait category, suggesting comparable processes regulate both sets of species. Our results illustrate that integrating trait-based approaches in the island biogeography framework can be a useful tool in understanding and predicting plant invasions.