bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Motivação de Serviço Público e a satisfação no trabalho: Pesquisa em uma Universidade Federal ## Public Service Motivation and job satisfaction: Research at the Federal University
Authors: Carvalho Kelle Dos Santos , La Falce Jefferson Lopes , Guimarães Ludmila De Vasconcelos Machado 
Published: January 2022

Desde o advento da Emenda Constitucional 19 tem-se implantado no país uma Administração Pública Gerencial, sendo que esta demanda por pessoal qualificado e com altos níveis de desempenho. Entender a motivação de servidores bem como níveis de satisfação pode ajudar os gestores na melhoria de desempenho. Este estudo teve como objetivo analisar os níveis de Motivação de Serviço Público e a satisfação no trabalho em servidores públicos, tendo como grupo alvo os servidores ativos de uma Universidade Federal de Minas Gerais. Foi realizada uma pesquisa descritiva e quantitativa utilizando os modelos satisfação no trabalho (Siqueira, 2008) e a Motivação de Serviço Público (Perry & Wise, 1990). Os resultados apontam níveis medianos de motivação e satisfação no trabalho o que pode indicar uma necessidade de revisão das políticas de RH da instituição. Verificou-se diferença significativa entre docentes e técnicos da organização em relação a motivação e satisfação. A análise das dimensões mostrou-se favorável a um diagnóstico mais detalhado dos dois construtos visto que os estudos internacionais aqui utilizados falharam nesse ponto, não mostrando um panorama completo de cada uma das dimensões, sendo essa uma contribuição deste estudo. Ao identificar níveis de motivação e satisfação diferentes, estes resultados podem auxiliar numa melhoria das funções gerenciais e administrativas da instituição, e possivelmente replicadas em instituições federais de ensino superior. Visto que a organização pode implementar políticas de RH, da base para o topo da organização, diferenciadas para cada categoria profissional e com maior possibilidade de assertividade.ABSTRACTSince the advent of Constitutional Amendment 19, a Public Management Administration has been implemented in the country, with this demand for qualified personnel with high levels of performance. Understanding the motivation of employees as well as satisfaction levels can help managers improve performance.
Resection of metastases in patients with BRAF mutated metastatic colon cancer: results of a multicenter retrospective study
Authors: Fedyanin M.  Yu. , Elsnukaeva H. H.‑M. , Demidova I.  A. , Stroyakovskii D.  L. , Shelygin Yu.  A. , Tsukanov A.  S. , Sergeev Yu.  S. , Ponomarenko A.  A. , Panina M.  V. , Shubin V.  P. , Moiseenko F.  V. , Karpenko E.  Yu. , Bolotina L.  V. , Kudriavtseva A.  V. , Filipenko M.  L. , Voskoboev M.  E. , Oskorbin I.  P. , Vladimirova L.  Yu. , Kit O.  I. , Stroganova A.  M. , Dranko S.  L. , Senderovich A.  I. , Tryakin A.  A. , Tjulandin S.  A. 
Published: January 2022

Introduction: local treatment of metastases is an integral part of colon cancer treatment. However, there is not enough data on the efficacy of surgical resection of metastases in patients with a BRAF gene mutation to recom‑mend this approach in routine practice. We initiated a retrospective multicenter study to assess the incidence of BRAF gene mutations in patients with metastatic colon cancer and to study the efficacy of metastasectomy in this group of patients.Materials and methods: we selected all patients who underwent surgical resection of metastases in various sites from the database of patients with BRAF gene mutations created as a result of a multicenter retrospective study with participation of 7 clinics in the Russian Federation. All 57 patients with RAS gene mutations and 43 patients with wild‑type RAS and BRAF genes who also underwent surgical resection of metastases at any stage of treatment were selected from the register of the Chemotherapy Department No. 2 of the NMRC of Oncology named after N. N. Blokhin for comparative analysis. Disease‑free survival and overall survival were used as primary efficacy criteria.Results: we found 26 patients with BRAF gene mutations who underwent surgical resection of metastases. When comparing disease‑free survival, the worst median was achieved in the group of patients with BRAF gene mutations: 7 months versus 14 months in patients with RAS gene mutations (HR 0.4, 94 % CI 0.23–0.7, P = 0.006); median disease‑free survival was not achieved in the wild‑type RAS and BRAF group (HR 0.2, 95 % CI 0.11–0.45, P <0.001).The median overall survival in the BRAF gene mutation group was 26 months versus 38 months in the RAS gene mutations group (HR 0.8, 95 % CI 0.33–1.98, P = 0.6) and 49 months in the wtRAS/wtBRAF group (RR 0.46, 95 % CI 0.17–1.24, P = 0.1). Resection of recurrent tumors in patients with metastases in retroperitoneal lymph nodes was associated with extremely low disease‑free survival (2 months); at the same time, disease‑free survival was 7 months after resection of isolated metastases in the liver and 8 months for metastases in the peritoneum.Conclusion: prognosis of patients with a BRAF gene mutation after surgical resection of metastases is worse than in patients with a different mutation phenotype. Nevertheless, literature data, as well as the results of our study, confirm the possibility of performing metastasectomy with careful selection of patients.
he effects of NETosis on fibrinolysis in colon cancer patients
Authors: Parshina A. A. , Tsybikov N. N. , Tereshkov P. P. , Karavaeva T. M. , Maksimenya M. V. 
Published: January 2022

Aim. To investigate formation of neutrophil extracellular traps (NETs) and their impact on fibrinolysis in patients with colon cancer.Materials and methods. The study was performed in two groups. The experimental group consisted of patients with stage 2–3 non-metastatic colon cancer (n = 17, average age – 67 years). The control group included healthy volunteers matched by sex and age (n = 30, average age – 68 years). An experimental model was created from the whole blood. It included platelet-poor plasma and an isolated culture of neutrophils, previously induced to NETosis by adding 100 nmol PMA. The samples were incubated for 4 hours, then the test tubes were centrifuged to pellet cells and their remnants, and the plasma was transferred for subsequent examination. The plasma incubated with intact neutrophils was used as a control. The levels of interleukin-8 (IL-8) and P-selectin glycoprotein ligand-1 (PSGL-1) were used to determine the degree of cell activation. NETosis was confirmed by enzyme-linked immunosorbent assay (ELISA) and fluorescent microscopy. Fibrinolysis was assessed using the thrombodynamics test. The results were compared with the levels of fibrinolytic system components measured by flow cytometry.Results. In the control group, NETosis induction contributed to pronounced neutrophil activation that was accompanied by an increase in the IL-8, PSGL-1, and plasminogen levels, a decrease in PAI-1, and enhancement of fibrinolysis, compared with the intact samples. Higher levels of IL-8, PSGL-1, plasminogen, and PAI-1 and intensified fibrinolysis were detected in the intact samples. However, PMA-induced NETosis did not result in an increase in the degree of activation and significant changes in the given parameters.Conclusion. NETosis promotes both formation and lysis of fibrin clots. However, in cancer patients, suicidal NETosis does not contribute to fibrinolysis due to intracellular protease depletion, which may be one of the mechanisms causing hypercoagulation and insufficient fibrinolysis in cancer.
Prevalence of diseases and pathological conditions in young people under 45 years of age with abdominal obesity in Siberia
Authors: Ragino Yu. I. , Khudyakova A. D. , Striukova E. V. , Denisova D. V. , Shcherbakova L. V. 
Published: January 2022

Aim. To study the prevalence of abdominal obesity in young people aged 25–44 years in Novosibirsk, as well as the prevalence of diseases and pathological conditions in individuals with abdominal obesity.Materials and methods. We conducted a cross-sectional, population-based study of the population of Novosibirsk aged 25–44 years. The screening examined 1,415 people, including 670 men and 745 women. For all individuals, we evaluated the presence of such conditions as abdominal obesity (AO), arterial hypertension (AH), increased body mass index (BMI), coronary heart disease (according to validated epidemiologic and functional criteria with ECG findings classified according to the Minnesota Code), diabetes mellitus (DM), reduced glomerular filtration rate (GFR), chronic bronchitis (CB), increased blood levels of total cholesterol (hypercholesterolemia) and lowdensity lipoprotein (LDL) cholesterol (hyper-LDL-cholesterolemia).Results. The prevalence of AO in the population of Novosibirsk aged 25–44 years was 42.4%: in men – 42.7%, in women – 42.1%. We found that AO had a significant direct effect on the development of AH (odds ratio (OR) = 2.550, 95% confidence interval (CI) 1.899–3.422, p = 0.0001), CB (OR = 1.830, CI 1.326–2.527, p = 0.0001), hypercholesterolemia (OR = 1.486, CI 1.193–1.851, p = 0.0001), hyper-LDL-cholesterolemia (OR = 1.527, CI 1.222–1.907, p = 0.0001) and a reverse effect on reduced GFR (OR = 0.603, CI 0.427–0.852, p = 0.004). In the male population under 45 years of age, AO had a significant direct effect on the development of AH, CB, hypercholesterolemia, and hyper-LDL-cholesterolemia. In the female population under the age of 45, AO had a significant direct effect on the development of DM, AH, CB, and hyper-LDL-cholesterolemia and a reverse effect on the reduced GFR development.Conclusion. Therefore, in the young Siberian population under 45 years of age, abdominal obesity is associated with the development of common diseases and pathological conditions.
The Effectiveness of Flipped Classroom on the Academic Achievement of University Undergraduates
Authors: Masadeh Thouqan Saleem 
Published: January 2022

<p>The present study aimed to investigate the effectiveness of Flipped Classroom in developing the achievement of university undergraduates. The quasi-experimental approach was used and three achievement posttests were carried out. Participants were (32) students who were in advance distributed to two groups, control and experimental. Analysis of Students' achievement grades revealed that the effectiveness of Flipped Classroom use, as a learning method needs time to take place in students' academic achievement and understanding of the learning materials because of the nature of the Flipped Classroom that flipped the whole learning process. Thus, students needed time to be familiar with this new learning method for them. Results showed that there was no significant difference between participants' achievement mean scores in the first posttest at the end of the fifth week due to the use of the Flipped Classroom or the ordinary methods. However, there was a significant difference between students' achievement mean scores in the second posttest in favor of the experimental group students who learnt the course content through the use of Flipped Classroom. In addition, there was a significant difference in student participants' mean scores in the third posttest in favor of the experimental group students, too. In light of these findings, it was concluded that the instructor and his students should be patient for some time for the effectiveness of using the Flipped Classroom learning method to be noticed. Moreover, considerable time should be spent on familiarizing students with this new learning method. </p>
Experimental Study on Shut-In-Time Optimization for Multi-Fractured Horizontal Wells in Shale Reservoirs
Authors: Tao Liang , Guo Jianchun , Lu Yong , Liu Yi , Zhao Yuhang , Li Geng , Zhao Zhihong , Chen Chi 
Published: January 2022

Abstract
The optimization of shut-in-time in shale gas well is an important factor affecting the production of single well after volume fracturing. In this study, a new method for determining the optimal shut-in-time considering clay mineral content and ion diffusion concentration was proposed. First, a novel water spontaneous imbibition apparatus under the conditions of formation temperature and confining pressure was designed. Then, the water imbibition satuation of 15 shale samples from the Longmaxi Formation (LF) of the Sichuan Basin were measured to quantitatively evaluate the water imbibition ability and classify reservoir types. Finally, the salt ion concentration diffusion experiment was carried out to optimize the shut-in-time of different types of shale reservoirs. The experimental results shown that the clay mineral content was the key factor affecting water wettability of shale, the shale reservoirs can be divided into two types and the critical value of clay mineral content was about 40%. Based on the law of salt ion diffusion in shale, the initiation time of micro-fractures induced by shale hydration was about 10-15 days. Under the experimental conditions, the optimal shut-in time of type I shale reservoir and type II shale reservoir were about 20 days and 15 days respectively. The average daily gas production has increased from 15.6×104 m3/day to 30.2×104 m3/day. The study results can provide scientific basis for the optimization of flowback regime of shale gas resrvoirs.
Integrated Hydraulic Fracturing and Well-Test Data Analytics using R
Authors: Vogelij Nico A. M. 
Published: January 2022

1. Abstract
Various datasets are generated during hydraulic fracturing, flowback- and well-testing operations, which require consistent integration to lead to high-quality well performance interpretations. An automated digital workflow has been created to integrate and analyze the data in a consistent manner using the open-source programming language R. This paper describes the workflow, and it explains how it automatically generates well performance models and how it analyzes raw diagnostic fracture injection test (DFIT) data using numerical algorithms and Machine Learning. This workflow is successfully applied in a concession area located in the center of the Sultanate of Oman, where to date a total of 25+ tight gas wells are drilled, hydraulically fractured and well-tested. It resulted in an automated and standardized way of working, which enabled identifying trends leading to improved hydraulic fracturing and well-testing practices.
Fracturing Technology - Can We Finally Control Fracture Height?
Authors: Rylance Martin , Korovaychuk Yaroslav 
Published: January 2022

Abstract
For as long as we have been performing hydraulic fracturing, we have been trying to ensure that we stay out of undesirable horizons, potentially containing water and/or gas. The holy grail of hydraulic fracturing, an absolute control of created fracture height, has eluded the industry for more than 70 years. Of course, there have been many that have claimed solutions, but all the marketed approaches have at best merely created a delay to the inevitable growth and at worst been a snake-oil approach with little actual merit. Fundamentally, the applied techniques have attempted to delay or influence the underlying equations of net-pressure and stress variation; but having to ultimately honour them and by doing so then condemned themselves to limited success or outright failure.
Fast forward to 2020, and a reassessment of the relative importance of height-growth constraint and what may have changed to help us achieve this. The development of unconventionals are focused on creating as much surface area as possible in micro/nano-Darcy environments, across almost any phase, but with typically poor line of sight to profit. However, the more valuable business of conventional oil and gas is working in thinner and thinner reservoirs with an often-deteriorating permeability, but with a significantly higher potential economic return. What unconventional has successfully delivered however, is a rapid deployment and acceleration in a range of completion technologies that were unavailable just a few years ago. We will demonstrate that these technologies potentially offer the capability of finally being able to control fracture height-growth.
Consideration of a range of previously applied height-growth approaches will demonstrate how they attempted to fool or fudge height growth creation mechanisms. With this clarity, we can consider what advances in completion technology may offer in terms of delivering height growth control. We suggest that with the technology and approaches that are currently available today, that height-growth control is finally within reach. We will go on to describe a multi-well Pilot program, in deployment and execution in 2020/021 in Western Siberia; where billions of barrels remain to be recovered in thin oil-rim, low permeability sandstone reservoirs below gas or above water.
A comprehensive assessment of the myriad of height-growth approaches that have been utilized over the last 70 years was performed, but in each case demonstrated the fallibility and limitations of each of these. However, rather than the interpretation that such control is not achievable, instead we will show a mathematically sound approach, along with field data and evidence that this is possible. The presentation will demonstrate that completion advances over the last 10 - 15 years make this approach a reality in the present day; and that broader field implementation is finally within reach.
Tobacco and Cannabis Debris Survey Protocol
Authors: De Werfhorst Laurie C. Van , Jerde Christopher L. , Beutel Marc W. , Brooks Andrew , Butsic Van , Duttagupta Srimanti , Gilmore Michelle E. , Harmon Thomas C. , Hart Stephen C. , Hoh Eunha , Iancu Liviu , Kefela Timnit , Novotny Thomas E. , Nynas Katelyn , Reynolds Becca , Wartenberg Ariani C. , Holden Patricia A. 
Published: January 2022

Abstract
Tobacco and cannabis product use can result in debris (a.k.a. litter) on the landscape, with implications to soil and water quality and thus potential impacts to ecosystems. More information is needed regarding how much debris exists on the landscape, such that the magnitude of potential associated environment problems can be quantified. Such information can raise awareness in the public about environmental hazards from tobacco and cannabis product use. The goal of this protocol is to quantify, via a timed survey approach, the tobacco and cannabis debris load (i.e. cigarette butts, cannabis or e-cigarette waste) at study sites. Multiple sites in a geographical location may be of interest for comparative analysis, for example sites used regularly by humans (e.g. trails, parking lots, around buildings, garbage cans) versus other sites that are suspected to have low human use. In any case, the same survey data sheet would be used (included with this protocol). Each survey will take 15 minutes per site to conduct. In the process of surveying, debris is collected and retained for later sorting, counting, and photographic documentation. The time to sort and count the collected debris will depend on the quantity and diversity of debris collected.
Efficacy of Combined Therapy with Nitroimidazole Drugs and Broad-Spectrum Antibiotics on Intra-Abdominal Infection: A 10 Years Real-World Cohort Study
Authors: Liang Hongyi , Xue Gaici , Ye Jiasheng , Wen Fangfang , Ouyang Leifang , Ji Jingjing , Ji Bo , Liu Zhifeng 
Published: January 2022

Abstract
Background: Abdominal infection still has a high mortality rate, and whether the combination of nitroimidazoles against obligate anaerobe could improve the outcome of abdominal infection remains controversial. ﻿Objective: This study aimed at exploring the clinical efficacy of broad-spectrum antibiotics combined with nitroimidazoles in the treatment of abdominal infection. Methods: Clinical data of patients with abdominal infection who received broad-spectrum antibiotics alone (BSA) or broad-spectrum antibiotics in combination with nitroimidazole (NCBSA) at a single center from June 2010 to May 2020 were retrospectively reviewed. One-to-one propensity score matching (PSM) was performed to adjust the potential differences in age, gender, APACHE II score and SOFA score of the two groups. Clinical effective rate, hospitalization days and total hospitalization costs were compared between the two groups. Meanwhile, subgroup efficacy was analyzed according to disease severity (APACH II score) and whether abdominal surgery was performed. Result: A total of 149 propensity score-matched case pairs were included in this study. There was no statistical difference in clinical effective rates between the two groups (P = 0.236). The patients in BSA group had shorter hospital stays (18d vs 27d, P = 0.001) and lower hospitalization costs (85185.7 yuan vs 187898.3 yuan, P < 0.001). However, the body temperature and PCT in patients in NCBSA group were higher than those in BSA group (P = 0.007 and P = 0.045, respectively), and CRP and WBC values in NCBSA group also were higher, but there were no significant differences between the two groups (P = 0.105 and P = 0.170, respectively). And more patients (92 vs 38) in NCBSA group underwent abdominal surgery, which indicated the infection and clinical conditons in NCBSA group were probably more severe. Subgroup analysis showed that the severity of the disease and whether the patient suffered postoperative co-infection did not affect the therapeutic effect of the two groups (P > 0.05). Conclusion: The clinical efficacy of broad-spectrum antibiotics combined with nitroimidazoles for abdominal infection was similar to that of broad-spectrum antibiotics alone, and whether the combination of nitroimidazoles in these conditions still needs more lcinical evidence.
Tenofovir Adherence in the Prevention of Mother-to-Child Transmission of Hepatitis B in the Democratic Republic of the Congo: A Qualitative Study Applying the Information-Motivation-Behavioral Skills Model
Authors: Thahir Sahal , Morgan Camille E. , Ngimbi Patrick , Mwandagalirwa Kashamuka , Ntambua Sarah , Matondo Jolie , Tabala Martine , Mbendi Charles , Kaba Didine , Yotebieng Marcel , Parr Jonathan B. , Banek Kristin , Thompson Peyton 
Published: January 2022

Abstract
Background: Hepatitis B virus (HBV) remains a leading infectious cause of death worldwide, and is highly prevalent in Sub-Saharan Africa (SSA). The prevention of mother-to-child transmission (PMTCT) programs for HBV are critical to reaching elimination targets and utilizing existing HIV testing and treatment infrastructure. Building on a feasibility study to introduce tenofovir disoproxil fumarate antiviral therapy to pregnant women with high-risk HBV in the Democratic Republic of the Congo (DRC), we examine the social and psychological facilitators of medication adherence of women who participated in this HBV PMTCT program.Methods: This study utilizes a qualitative exploratory approach involving women in Kinshasa, DRC who were identified as high-risk HBV during pregnancy and completed the pilot tenofovir antiviral program. Six participants were identified and completed in-depth, open-ended phone interviews. This study adopts a modified Information-Motivation-Behavioral Skills model (IMB+) to identify emerging themes related to tenofovir adherence.Results: A strong trust in healthcare workers, family support, and improved awareness of the disease and treatment options through enrollment in the PMTCT program facilitated tenofovir adherence. Barriers to medication adherence included social stigma and low healthcare literacy specific to HBV.Conclusions: Our study highlights the feasibility of medication adherence in HBV PMTCT programs in a low-resource setting and the importance of incorporating initiatives that address hepatitis B stigma and other social barriers. These findings are relevant to future HBV PMTCT scale-up, which is needed in the DRC and in similar African contexts with high HBV prevalence. Trial registration: The parent study was registered with clinicaltrials.gov under identifier NCT03567382. Date of registration: 25/06/2018