bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatic and Molecular Interaction Studies Uncover That CCA-1.1 AND PGV-1 Differentially Target Mitotic Regulatory Protein and Have a Synergistic Effect against Leukemia Cells
Authors: Meiyanto Edy , Novitasari Dhania , Utomo Rohmad Yudi , Susidarti Ratna Asmah , Putri Dyaningtyas Dewi Pamungkas , Kato Jun-ya 
Published: March 2022

Numerous studies demonstrated CCA-1.1, the modified compound from PGV-1, inhibits tumor cells growth in breast and colorectal cancer. This time, we used bioinformatics and molecular interaction approaches to ascertain the potential CCA-1.1 activity target focusing on leukemia, along with the cytotoxic test in leukemia cells. Genomics data expression was collected through the COSMIC database by selecting gene sets from K562 cells as a model for chronic myelogenous leukemia (CML). We identified CCA-1.1 and PGV-1 predicted targets through SwissTargetPrediction. The overlapping genes between the CCA-1.1, PGV-1, and K562 cells were chosen for further analysis. We narrowed down the potential targets by using the list of genes involved in the cell cycle and mitosis collected through GeneCards. A molecular docking study was applied to determine the molecular interaction between CCA-1.1 or PGV-1 and the predicted protein target. We carried out a cytotoxic test using a trypan blue exclusion assay. We treated K562 cells with CCA-1.1 and PGV-1 in single and combination treatment to determine the half concentration of growth inhibitory (GI50) and combination index (CI) score. CCA-1.1 and PGV-1 shared similar predicted target genes in mitosis, and interestingly CCA-1.1 were mainly targeted in Aurora A (AURKA) in K562 cells with lower docking scores against the inhibitor in molecular docking analysis. Moreover, each compound exhibited an inhibitory effect similarly, and the co-treatment resulted in a synergistic effect in K562 cells. Collectively, we indicated that CCA-1.1 and PGV-1 possibly targeted mitosis in cell cycle progression, and along with their specific targets, led to their synergistic activity in CML. These findings should be validated through experimental studies to provide more pharmacological activities of CCA-1.1 to cure CML.
Corporate Governance and Tax Avoidance: Evidence from U.S. Cross-Listing
Authors: Chen Ruiyuan , El Ghoul Sadok , Guedhami Omrane , Wang He , Yang Yang 
Published: April 2022

ABSTRACT
Using a sample of firms from 51 countries and a difference-in-differences approach that exploits corporate governance shocks induced by cross-listing in the U.S., we find that firms tend to engage in less tax avoidance after cross-listing. This effect is more pronounced for firms that experience significant improvements in corporate governance, and for firms from countries with weaker shareholder protection and disclosure requirements. Taken together, the results indicate that cross-listing in the U.S. helps align the interests of managers and shareholders and reduces managerial diversion.
Data Availability: All data are publicly available from sources indicated in the text.
JEL Classifications: G21; G18; G32; G34; G35.
Fair Value Measurement Discretion and Opportunistic Avoidance of Impairment Loss Recognition
Authors: Hodder Leslie D. , Sheneman Amy G. 
Published: April 2022

ABSTRACT
Studies find evidence that opportunistic reporting often accompanies fair value measurement. However, research has not determined whether the source of this opportunism is the estimate of fair value. Using detailed information on insurers' investment holdings, we separate the use of fair value measurement discretion from the application of non-measurement-related discretion in accounting for impairments of financial assets. Our evidence contradicts the view that fair value measurement discretion plays a large role in opportunistic avoidance of impairment recognition for investment securities. Instead, managers appear to avoid recording impairment losses by opportunistically applying subjective criteria regarding perceived loss persistence and intent to hold.
Data Availability: Data are available from sources identified in the paper.
JEL Classifications: G20; G22; G30; M41.
EFEKTIVITAS PENDAFTARAN DAN PENCATATAN NIKAH BERBASIS APLIKASI SIMKAH DI KUA KECAMATAN MA'RANG KABUPATEN PANGKEP
Authors: Kartika Kartika , Supardin Supardin 
Published: April 2022

SIMKAH (Sistem Informasii Manajemen Nikah) adalah aplikasi windows yang berguna mengumpulkan data-data nikah dari seluruh kantor urusan agama di Indonesia secara “online”. Adapun persoalan yang dikaji dalam skripsi ini, yaitu efektivitas pendaftaran dan pencaatatan nikah berbasis aplikasi SIMKAH di KUA kecamatan Ma’rang. Tujuan dalam penelitian ini adalah untuk mengantisipasi adanya tindakan manipulasi data yang terjadi di KUA. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian lapangan yang bersifat deskriptif, pendekatan yang digunakan adalah pendekatan kualitatif, jenis data yang digunakan adalah data primer, dan data sekunder. Hasil pembahasan dalam penelitian ini ditemukan bahwa adanya problematika pada program aplikasi SIMKAH pada KUA kecamatan Ma’rang, yaitu kurang memadainya jaringan internet, KUA kecamatan Ma’rang belum bekerjasama dengan dinas kependudukan dan catatan sipil sehingga aplikasi SIMKAH ini masih kurang efektif di KUA kecamatan Ma’rang kabupaten Pangkep.Kata kunci: Efektivitas, KUA, dan SIMKAH
Legal Reasoning Hakim dalam Menentukan Besaran Bagian Harta Bersama dalam Perkara Perceraian (Studi Putusan Nomor 139/Pdt.G/2017/PA Takalar 1B)
Authors: Marfuah Nurul Ainun , Erlina Erlina 
Published: April 2022

AbstrakSkripsi ini membahas tentang Dasar Pertimbangan Hakim Dalam Menentukan Besaran Bagian Harta Bersama, selanjutnya pokok permasalahan yaitu: 1) Bagaimana proses penyelesaian perkara perceraian pada Pengadilan Agama di Kabupaten Takalar, 2) Bagaimana pertimbangan hukum hakim dalam memutuskan pembagian harta bersama dalam perkara perceraianPenelitian ini mengkaji tentang dasar pertimbangan hakim dalam menentukan besaran bagian harta bersama. Penelitian ini menggunakan metode penelitian Empiris, dengan pendekatan yang digunakan adalah pendekatan penelitian hukum normative-yuridis dengan sumber data yang diperoleh dari observasi dan wawancara di Pengadilan Agama Takalar. Selanjutnya metode pengumpulan data yang digunakan dalam skripsi tersebut adalah observasi, wawancara, dokumentasi. Kemudian teknik pengolahan data dilakukan melalui beberapa tahapan yakni: data (memilah milih data), reduksi data, editing data.Hasil penelitian ini menunjukkan bahwa, (1) Penelitian menunjukkan bahwa pembagian harta bersama antara pihak Penggugat dan Tergugat yaitu 40 : 60, (2) Pertimbangan hakim dalam memutuskan pembagian harta bersama dalam perkara perceraian pada putusan No. 139/Pdt.G/ 2017/PA Tkl yaitu membagi harta bersama dengan berlandasan dari rasa keadilan. Keywords: Harta Bersama, Pertimbangan, Pembagian.
Transoral ventral tympanic bulla osteotomy in cats: 13 cases (2016–2019)
Authors: Moissonnier Pierre H. M. , Blondel Margaux , Manou Maria , Viguier Eric 
Published: March 2022

Abstract

OBJECTIVE
To analyze the results of transoral ventral bulla osteotomy (TOVBO) in cats.

ANIMALS
13 client-owned cats treated by TOVBO between February 2016 and February 2019.

PROCEDURES
Medical records of cats with a diagnosis of middle ear disease (MED) that underwent TOVBO were reviewed. The procedure was similar to the one described for dogs. Short-term follow-up was obtained via clinical examination before discharge and at day 15 postoperatively. Long-term follow-up was performed via telephone interview.

RESULTS
13 cats (age range, 8 months to 12 years) underwent unilateral (n = 10) or bilateral (3) TOVBO (16) for the treatment of tympanic bulla (TB) infection (10), nasopharyngeal inflammatory polyps (5), or bullet retrieval from the TB (1). There were no intraoperative complications. One cat with a poor preoperative status died at postoperative day 3 from pneumonia. Eight cats experienced postoperative complications including head tilt (n = 2), Horner syndrome (3), loss of appetite (2), and temporary blindness (1). Collected samples confirmed the presence of nasopharyngeal inflammatory polyps (5), or otitis media (8). Six months after surgical intervention, 9 cats were free of MED signs.

CLINICAL RELEVANCE
This oral approach provided a good access to the TB in all cases. The complications observed after TOVBO were similar to those for VBO. In cats, TOVBO seems to be an acceptable and safe minimally invasive alternative to the other approaches of the TB to address MED.
Alpine huts: Architectural innovations and development in the High Tatras until the first half of the 20th century
Authors: Novotná Mária 
Published: March 2022

Abstract
For man, the mountain environment was a source of raw materials and a place of economic activity until the end of the 18th century. This paper examines how the exploration of mountain valleys lead from the first ascents to the peaks to today’s exploitation of the mountain environment. We are currently following efforts to protect the unique environment of the mountains and to preserve the architectural heritage of the 20th century. In the paper, we look at the architecture of the High Tatras of the first half of the 20th century, which is lost under the coatings of today. The article traces the line of innovation in the 20th century and examines the causes and consequences of the origin and development of architecture in the alpine environment, with a focus on changes in the paradigm of social thinking in the relationship between architecture and the original landscape. The subject of the paper is mapping of the architectural heritage embedded in the unique environment of the world natural heritage of alpine terrains in the High Tatras and the study of the settlement process with innovative technologies and materials that have enabled architecture to enter difficult terrains. As industrialization, mechanization and electrification have greatly simplified and streamlined the construction process, the work identifies not only the development of new design, technological and material solutions, but also the resilience of the environment to innovation. It focuses on the analysis of innovative progress and monitors its development in contact with the mountain architecture from the moment of planning, work implementation and possible construction changes. The work focuses on the typology of mountain huts and the process of their architectural design.
Route options in inclusive museums: Case studies from Central Europe
Authors: Filová Natália , Rollová Lea , Čerešňová Zuzana 
Published: March 2022

Abstract
Museums are complex architectural works with many distinctive elements. One of the most significant museum features are routes or paths on which visitors circulate museums and perceive exhibitions. Children and people with special needs often have specific demands on physical accessibility of the surrounding environment, chronological arrangement of spaces and amount of information presented at a time. The arrangement of functional units in museum layouts affects wayfinding in space, understanding of the exhibition, as well as visitor guidance. The order in which people visit particular segments in a museum can also be described as one of the most important architectural and operational characteristics of this type of cultural buildings and areas. The article examines ways of arranging spaces in a museum building and the suitability of their application. These forms are evaluated based on various aspects; some of the created effects are studied, e.g. creation of a desired atmosphere. Existing concepts are compared and supplemented with other theoretical knowledge. The article aims to present variant suitable ways of composing routes that would meet the needs of different people, and bring them a quality leisure and educational experience from a museum tour. Various types of museum layout organisation and arrangement of exhibition spaces are illustrated with abstract schemes, as well as with specific case studies of five selected museums. The selection consists of architecturally exceptional and high-quality museums in Central Europe, which are able to attract a whole range of various groups of people including a younger audience. They are examples of both modern museums in this area and route planning options. The case studies highlight interesting local ideas, space concepts, routing methods, and also solutions for increasing inclusion of all visitors and children in particular.
The impacts of climate change on urban structures in Slovak cities: Identifying vulnerable urban structures
Authors: Kamenská Miroslava , Smatanová Katarína 
Published: March 2022

Abstract
In the coming decades, our cities will face extreme weather caused by climate change, which they will have to adopt. Adaptation of the urban environment is attracting the growing attention of planners, researchers, and policy makers in Slovakia and around the world. As essential for urban environment, the National Adaptation Strategy identified the adaptation at local level, which represents the participation of municipalities, supports the development of local adaptation strategies and subsequent implementation of actions that provide the cities with stronger sustainability and resilience. Within the last 8 years since the adoption of the national strategy, only 8 out of 141 Slovak cities in total elaborated an adaptation strategy that could be considered for further investigation. Consequently, this paper aims to broaden our knowledge of the two most significant impacts of climate change–heatwaves and floods–on urban structures in Slovak cities and validate the importance of spatial vulnerability analyses as a considerable tool for the expected unified national methodology for developing local adaptation strategies. The study examines analyses of spatial vulnerability to heat-waves in Hlohovec, Košice – Západ, and Trnava, and analyses of spatial vulnerability to floods in Hlohovec and Kežmarok, developed as part of vulnerability assessment within the framework of adaptation strategies of these cities. The analyses selected for comparison allow us to identify vulnerable urban structures and provide a deeper understanding of the causes of vulnerability in Slovakia, which is crucial for the development of adaptation strategies in the future and the building of resilience in Slovak cities. The article provides an exploratory spatial analysis of vulnerability hotspots. Based on the findings, it outlines the principles of spatial planning and urban structures that are resilient to the impacts of heatwaves and floods.
The Ship as an Extension of Flag State Territory and an Entity with Human Attributes – Is it Time to Jettison These Legal Fictions?
Authors: Gauci Gotthard Mark 
Published: March 2022

Summary
This article questions the need for the use of two legal fictions in modern maritime law: that a vessel/ship can in certain instances be treated as an extension of flag state territory; that a vessel/ship is an entity with human attributes. The article addresses the first ‘fiction’ mainly in the context of applicable international law as well as English law; the second ‘fiction’ is addressed mainly in the context of English law although selective reference is made to both primary and secondary legal sources from the United States. The article concludes that the two fictions are only of limited value in modern maritime law.
The Interrelation Between the EU Charter of Fundamental Rights and the Schengen Agreement: The Ne Bis in Idem Example Through the CJEU Case Law
Authors: Margaritis Konstantinos 
Published: March 2022

Summary
The ne bis in idem principle is of fundamental nature to the legal order of every democratic society. The concept of this principle refers to the prohibition, on behalf of State authorities, on prosecuting the same person more than once for the same conduct. In two preliminary ruling procedures, the national courts set questions to the Court of Justice regarding the compatibility of articles 54 and 55 CISA respectively with article 50 of the EU Charter of Fundamental Rights. In the first case, the Court ruled that article 54 CISA is compatible with article 50 of the Charter whilst, in the second, the Court, essentially, found unnecessary to reply to the question. The aim of this paper is to offer a review on the impact of these two judgments in the formulation of article 50 of the EU Charter and subsequently, propose an alternative approach on the interpretation of this provision, in line with the core of the ne bis in idem principle, in order to underline the significant role of the Charter in the future of the Union.
Similarities and Differences Between the Albanian and Italian Succession Law
Authors: Pupe Ervin , Koka Enkelejda , Venditti Carlo , Picaro Raffaele , Ajazi Rea , Veshi Denard 
Published: March 2022

Summary
In 1994, Albania codified the current civil code, harmonizing the national legislation with the democratic values of the Western European Countries. This paper fills the gap in the national and international scientific literature since there is no scientific contribution that examines the Albanian law of succession showing the similarities and differences between the Albanian and the Italian civil codes. This is fundamental because according to Article 33 Albanian Private International Law (Albanian Law no. 10 428 of June 2011), which governs cross-border succession law, in the case of immovable goods, the rule of lex rei sitae has been codified. Thus, in the case of immovable goods, the Albanian succession law will be applied to them. In the conclusion, this research demonstrates that the Albanian Law of Succession of 1994 is different in many ways from the rules established in the Italian Civil Code of 1942.
Econometric Issues in Hedonic Property Price Indices: Some Practical Help
Authors: Silver Mick 
Published: March 2022

Abstract
Hedonic regressions are widely used and recommended for property price index (PPI) measurement. Hedonic PPIs control for changes in the quality-mix of properties transacted that can confound measures of change in average property prices. The widespread adoption of the hedonic approach is primarily due to the increasing availability, in this digital age, of electronic data on advertised and transaction prices of properties and their price-determining characteristics. Yet hedonic PPIs are only as good as the underlying estimated hedonic regressions. Regression-based measures are unusual in official economic statistics. There is little technical support in the international Handbooks and Guides for diagnostic measures and graphical plots for estimated regression equations as applied to PPIs. These diagnostics are essential to the transparency and credibility of hedonic PPI measurement. This article seeks to remedy this.
Analisis Histologi dan Scaning Elektron Mikroskopy (SEM) pada Somatik Embriogenesis Tanaman Porang (Amorphophallus muelleri B)
Authors: Hariyanto Dwika Nano , Handoyo Tri , Dewanti Parawita , Hariyono Kacung , Restanto Didik Pudji 
Published: April 2022

Pembentukan Somatik Embriogenesis (SE) porang secara tidak langsung memiliki proses yang lambat, selama ini yang digunakan adalah induksi secara langsung karena dapat mempercepat penyediaan bibit tetapi pengetahuan tentang induksi SE secara tidak langsung sangat dibutuhkan untuk mengetahui tahapan perkembangannya. Kami menyajikan pengetahuan terkait interaksi hormon 2,4-D dan NAA terhadap induksi kalus, histologi dan scanning elektron microscop (SEM) kalus embriogenik tanaman porang (Amorphophallus muelleri). Tujuan penelitian ini adalah guna mengetahui interaksi pengaruh 2,4-D dan NAA dalam proses induksi SE dan mempelajari tahapan perubahan embrio serta perkembangan struktur embrio tanaman porang. Penelitian ini telah dilangsungkan selama 6 bulan sejak Mei hingga Oktober 2021. Tempat penelitian berada di Laboratorium Kultur Jaringan Agronomi Fakultas Pertanian Universitas Jember. Penelitian ini mengunakan Rancangan Acak Lengkap (RAL) 2 Faktor dengan 3 kali ulangan. Faktor pertama ialah hormon 2,4-D dengan konsentrasi 0 ppm, 1 ppm, 2 ppm, dan faktor kedua yaitu hormon NAA dengan konsentrasi 0,5 ppm, 1 ppm, 1,5 ppm, 2 ppm, 2,5 ppm, kemudian data yang didapatkan dilakukan analisis deskriptif dan ANOVA. Hasil penelitian menunjukan perlakuan hormon 1 ppm 2,4-D dan 1,5 ppm NAA menghasilkan kalus embriogenik dan pada hasil histologi dan scaning electron mikroskopy (SEM) memperlihatkan tahapan embrio somatik porang meliputi tahapan proembrio, embrio globular, skutelar dan kolioptilar, lalu tahap koleoptilar berkembang ke tahap primodial tunas. Pada konsentrasi 1 ppm 2,4-D dan 1,5 ppm NAA terbentuk proembrio dan embrio globular yang memiliki permukaan proembrio yang halus.
FAKTOR DETERMINASI TRANSFER PRICING (STUDI EMPIRIS PADA PERUSAHAAN FOOD AND BEVERAGES PERIODE 2017-2020)
Authors: Gabriella Stephanie Fransisca , Dwi Bimo Kun , Widyatiningsih Tyas , Suryaputri Rossje V. 
Published: March 2022

This study aims to examine the effect of tunneling incentives, bonus plan and firm size as instruments in detecting the company's decision to transfer pricing. The independent variables in this research are tunneling incentives, bonus plan and firm size as well as leverage and firm size as control variables. The sample was taken by purposive sampling method consisting of 60 food and beverages companies of consumer goods industry sector listed in Indonesia Stock Exchange which have reported complete financial report in period 2017-2020. Test of hypothesis was using SPSS 25 application. The results show that tunnelling incentive has positive significant on transfer pricing and fiirm size has weaken positive significant on transfer pricing. Meanwhile, other independent variable bonus plan has no significant effect.