bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manu
Authors: Guo Rentong , Luan Xiaofan , Xiang Long , Yan Xiao , Yi Xiaomeng , Luo Jigao , Cheng Qianya , Xu Weizhi , Luo Jiarui , Liu Frank , Cao Zhenshan , Qiao Yanliang , Wang Ting , Tang Bo , Xie Charles 
Published: September 2022

With the development of learning-based embedding models, embedding vectors are widely used for analyzing and searching unstructured data. As vector collections exceed billion-scale, fully managed and horizontally scalable vector databases are necessary. In the past three years, through interaction with our 1200+ industry users, we have sketched a vision for the features that next-generation vector databases should have, which include long-term evolvability, tunable consistency, good elasticity, and high performance.
We present Manu, a cloud native vector database that implements these features. It is difficult to integrate all these features if we follow traditional DBMS design rules. As most vector data applications do not require complex data models and strong data consistency, our design philosophy is to relax the data model and consistency constraints in exchange for the aforementioned features. Specifically, Manu firstly exposes the write-ahead log (WAL) and binlog as backbone services. Secondly, write components are designed as log publishers while all read-only analytic and search components are designed as independent subscribers to the log services. Finally, we utilize multi-version concurrency control (MVCC) and a delta consistency model to simplify the communication and cooperation among the system components. These designs achieve a low coupling among the system components, which is essential for elasticity and evolution. We also extensively optimize Manu for performance and usability with hardware-aware implementations and support for complex search semantics. Manu has been used for many applications, including, but not limited to, recommendation, multimedia, language, medicine and security. We evaluated Manu in three typical application scenarios to demonstrate its efficiency, elasticity, and scalability.
Low loss flexibility and high efficiency of radio per fiber system for modern wireless communication system
Authors: Smirani Lassaad K. , Abd El-Aziz Ismail A. , Ahammad SK Hasane , Hossain Md. Amzad , Daher Malek G. , Rashed Ahmed Nabih Zaki 
Published: September 2022

Abstract
This article outlined intermediate/radio frequencies over fiber system performance efficiency measurement for the designed circuit frequencies. Output power, max. Q factor, and optical and electrical signal per noise ratio are also reported against radio and intermediate frequencies for the suggested system with the previous system. The suggested system has reported better efficiency and low loss flexibility than the previous system in the mentioned performance parameters. This study has clarified the low loss flexibility and high efficiency of radio per fiber system for modern wireless optical systems. We have clarified intermediate/radio frequencies over fiber system performance efficiency measurement in the presence of s and z parameters for the designed circuit frequencies. The comparison of the performance simulation parameters based on the previous/proposed models is clarified in the range of radio frequency and intermediate frequency range.
Intra-amniotic inflammation in the mid-trimester of pregnancy is a risk factor for neuropsychological disorders in childhood
Authors: Gervasi Maria Teresa , Romero Roberto , Cainelli Elisa , Veronese Paola , Tran Maria Rosa , Jung Eunjung , Suksai Manaphat , Bosco Mariachiara , Gotsch Francesca 
Published: September 2022

Abstract

Objectives
Intra-amniotic inflammation is a subclinical condition frequently caused by either microbial invasion of the amniotic cavity or sterile inflammatory stimuli, e.g., alarmins. An accumulating body of evidence supports a role for maternal immune activation in the genesis of fetal neuroinflammation and the occurrence of neurodevelopmental disorders such as cerebral palsy, schizophrenia, and autism. The objective of this study was to determine whether fetal exposure to mid-trimester intra-amniotic inflammation is associated with neurodevelopmental disorders in children eight to 12 years of age.

Methods
This is a retrospective case-control study comprising 20 children with evidence of prenatal exposure to intra-amniotic inflammation in the mid-trimester and 20 controls matched for gestational age at amniocentesis and at delivery. Amniotic fluid samples were tested for concentrations of interleukin-6 and C-X-C motif chemokine ligand 10, for bacteria by culture and molecular microbiologic methods as well as by polymerase chain reaction for eight viruses. Neuropsychological testing of children, performed by two experienced psychologists, assessed cognitive and behavioral domains. Neuropsychological dysfunction was defined as the presence of an abnormal score (<2 standard deviations) on at least two cognitive tasks.

Results
Neuropsychological dysfunction was present in 45% (9/20) of children exposed to intra-amniotic inflammation but in only 10% (2/20) of those in the control group (p=0.03). The relative risk (RR) of neuropsychological dysfunction conferred by amniotic fluid inflammation remained significant after adjusting for gestational age at delivery [aRR=4.5 (1.07–16.7)]. Of the 11 children diagnosed with neuropsychological dysfunction, nine were delivered at term and eight of them had mothers with intra-amniotic inflammation. Children exposed to intra-amniotic inflammation were found to have abnormalities in neuropsychological tasks evaluating complex skills, e.g., auditory attention, executive functions, and social skills, whereas the domains of reasoning, language, and memory were not affected in the cases and controls.

Conclusions
Asymptomatic sterile intra-amniotic inflammation in the mid-trimester of pregnancy, followed by a term birth, can still confer to the offspring a substantial risk for neurodevelopmental disorders in childhood. Early recognition and treatment of maternal immune activation in pregnancy may be a strategy for the prevention of subsequent neurodevelopmental disorders in offspring.
Investigation of muscle fatigue of the archer’s during endurance shooting
Authors: Hamdan Zul Amer , Ahmad@Manap Zulkifli , Johari Nasrul Hadi 
Published: September 2022

Endurance of Drawing-Aim-Release (DAR) during the shooting process in archery will be causing the muscles to fatigue. Besides, the archer's inability to use the right muscles for DAR will lead to a muscle injury as well as dropping the performance. This study aims to monitor the localized muscle fatigue of an archer during the repetitive DAR and its effect to the archer’s performance. Wet electrode sensors were placed on the specific muscles that are heavily involved in DAR such as Muscle Extensor Digitorum (MED) on the archer's bow arm and the Supraspinatus muscle at the shoulder. In order to induce fatigue, the archer has shot 72 arrows continously in 2 rounds of set. The surface electromyography (sEMG) signals of the muscle contraction are recorded during the shooting for the post-processing analysis. Each score of the shooting was also recorded to correlate with the effect of muscle fatigue to the archer’s performance. The finding of this study is that the MED and Supraspinatus begin to fatigue toward the end of each shooting round. The Root Mean Square (RMS) and Median Frequency (MDF) values for both targeted muscles increased significantly during the 6th end compare to the 1st end. It is also found that there is no correlation between muscle fatigue on MED and Supraspinatus to the score obtained by the archer where the F value is lower than F-critical while Draw (1.9339), Aim (1.3754) and Release (0.6515) phases. In conclusion, this experiment benefits archers and coaches to identify which muscles are vigorously used during the DAR process and allows for precaution and prevention procedures.
Potential utility of a non-invasive menstrual blood immunophenotype analysis in reproductive medicine
Authors: Marron Kevin , Harrity Conor 
Published: September 2022

The purpose of this study was to determine if a comprehensive flow cytometry panel could be used to assess immunophenotype profiles in menstrual blood of patients experiencing reproductive failure and age-matched controls of proven fertility. Menstrual blood samples of 58 recurrent pregnancy loss and repeated implantation failure patients, along with 15 age-matched controls of proven fertility, were obtained within the first 24 h of the onset of menstruation to non-invasively assess the local immunophenotype. Using a comprehensive multi-parameter flow panel, the lymphocyte sub-populations were described and compared. In relation to well-established peripheral blood immunophenotyping values, distinct lymphocyte population differences were noted between the subgroups. The ratios of CD4+ and CD8+ T-cells were inverted in relation to peripheral blood, and uterine natural killler (NK) cells represented by CD56bright were distinctly visualised, emphasising the distinction between menstrual and peripheral blood. In relation to controls, there were marked increases in CD3+ve T-cells (P = 0.009), CD4:CD8 ratio (P = 0.004), CD19 B-cells (P = 0.026) and CD56dim NK cells (P = 0.002) in the reproductive failure cases. The study shows that flow cytometric evaluation could provide a rapid and objective analysis of lymphocyte subpopulations in many forms of tissue and fluid. The findings show significant variations in cellular composition of immune cells indicating a distinct compartment, with differences between cases and controls. Immunological assessment of the menstrual blood immunophenotype, in clinically appropriate patients, may provide insight into the aetiology of adverse reproductive outcome, without the risks and inconveniences associated with a more invasive endometrial biopsy.

Lay summary
Unexplained infertility is a difficult issue for patients and physicians, but despite diagnostic strides and innovative methods, there are no clear solutions. The involvement of an overactive or underactive immune system in selected cases is undeniable, and the endometrial lining is the most relevant area for investigation because this is where the embryo implants. Endometrial investigations, however, are highly invasive, involve medication and have to be done at the right time. The method described and evaluated here is an alternative assessment which avoids these difficulties and can be used in a clinical setting.
Liver receptor homolog 1 (LRH-1) regulates follicle vasculature during ovulation in mice
Authors: Guzmán Adrian , Hughes Camilla H K , Murphy Bruce D 
Published: September 2022

In brief
It is well-established that liver receptor homolog 1 (LRH-1/NR5A2) regulates the ovarian function and is required for ovulation and luteinization in mice. In the present experiment, we showed that LRH-1 is required to control vascular changes during ovulation, a novel mechanism of action of this orphan nuclear receptor.

Abstract
Liver receptor homolog 1 (LRH-1/NR5A2) is a key regulator of ovarian function, and recently, it has been suggested that it may regulate changes in follicular angiogenesis, an important event during the ovulatory process and luteal development. In the present experiment, the objective was to determine whether conditional depletion of LRH-1 in mice granulosa cells modified vascular changes during the periovulatory period and to explore the possible mechanisms of this modification. We generated mice (22- to 25-day-old) with specific depletion of LRH-1 in granulosa cells by crossing Lrh1 floxed (Lrh1 f/f) mice with mice expressing Cre-recombinase driven by the anti-Müllerian type II receptor (Amhr2-cre; conditional knockout or cKO mice). We showed that preovulatory follicles of LRH-1 cKO mice had a reduced number of endothelial cells in the theca cell layer at 8 h after human chorionic gonadotropin treatment compared with control (CON) mice. Additionally, mRNA and protein expression of leptin receptor (LEPR), a protein that stimulates angiogenesis in a vascular endothelial growth factor-A (VEGFA)-dependent manner, and teratocarcinoma-derived growth factor-1 (TDGF1), which may directly stimulate endothelial cell function, were reduced in LRH-1 cKO mice as compared to CON after the LH surge. These results showed that LRH-1 is necessary for the correct vascular changes that accompany ovulation in mice and that this effect may be regulated through VEGFA-dependent and VEGFA-independent pathways mediated by LEPR and TDGF1.
Factores psicosociales en residentes de especialidades médicas en Barranquilla. Dimensiones demandas de trabajo
Authors: Pinillos Patiño Yisel , Acosta Fernández Martín , Jiménez Torres Susana , Gauna Quiñonez Aura 
Published: September 2022

Objetivo Describir los factores psicosociales en las dimensiones demandas de trabajo en los residentes de especialidades médicas en Barranquilla. Métodos Estudio cualitativo con metodología fenomenológica en residentes de especialidades médicas adscritos a una institución de educación superior en Barranquilla. Mediante entrevistas en profundidad se recogieron las experiencias, vivencias y consideraciones manifestadas en su vida cotidiana y en su salud mental, frente a las situaciones que afrontan a diario en su formación en el contexto laboral en medio de la ejecución de sus responsabilidades operativas. Resultados En el dominio de demandas de trabajo se concentraron las cinco dimensiones más sobresalientes, con 266 testimonios-demandas de autocontrol emocional; seguidos de 237 en la dimensión demandas cuantitativa; 165, en demandas de carga mental; 152, en demandas ambientales y de esfuerzo físico; y 142, en exigencias de responsabilidad del cargo. Conclusiones Es importante revisar las cargas de las demandas de trabajo a lo largo del curso de la residencia de las especialidades medico quirúrgicas para disminuir los riesgos psicosociales en el desempeño de sus funciones.
Generalist diets allows opportunism behavior to engage in cleaning interactions among birds and large mammals
Authors: Acquaviva Julia , Guimarães Junior Paulo Roberto 
Published: September 2022

Cleaning interactions are interspecific associations in which cleaners benefit from the hosts by feeding on parasites, injured tissues, or blood. All around the globe there is a remarkable diversity of birds that behave as cleaners of large mammals. Here we investigated the drivers shaping the organization of networks formed by cleaning birds and host mammals. We used two cleaner-host networks, one from Brazilian openlands and the other one from African openlands, to explore the relationship between diet generalism and cleaning behavior. We hypothesize that cleaning interactions are often opportunistic and, as a consequence, we expect that generalist species are the main components of cleaner-host networks. We first contrast the diet diversity of cleaner species with their closed related species. For 18 of 26 bird families, cleaners show higher diet diversity than closely-related, non-cleaning species. Then we explored if birds with higher diversity diets are the central species of the cleaner-host networks. The results show that there is no apparent correlation between species centrality in the networks and their diet diversity. We suggest that generalism allows opportunist species to engage in cleaning interactions, but the importance of a cleaner species is affected by other attributes, such as abundance and behavioral traits associated with cleaning behavior. In a broader perspective, these results suggest that the factors that may allow species to participate in ecological networks are not the same that modulate their role in the same networks.
Fen Bilimleri Ders Kitaplarındaki Soruların PISA’da Tanımlanan Fen Okuryazarlığı Yeterlik Düzeylerine Göre İncelenmesi
Authors: KÖMÜRCÜ Azize Sultan , YENİLMEZ TÜRKOĞLU Ayse 
Published: September 2022

Öz: Bu araştırmanın amacı 5-8. sınıf fen bilimleri ders kitaplarında yer alan ölçme-değerlendirme sorularının PISA fen okuryazarlığı yeterlik düzeylerine göre incelenmesidir. Bu kapsamda, ders kitaplarında bulunan soruların yeterlik düzeyleri sınıf seviyelerine ve öğretim programında tanımlanan öğrenme alanlarına göre incelenmiştir. Araştırmada, nitel araştırma yöntemlerinden doküman incelemesi yöntemi benimsenmiş ve verilerin analizinde betimsel analiz kullanılmıştır. PISA’da fen okuryazarlığı yeterlik düzeyleri 6 seviyede tanımlanmaktadır. Bu araştırma kapsamında, kitaplarda yer alan toplam 1209 adet ölçme değerlendirme sorusu bu seviyelere göre incelenmiştir. Elde edilen bulgular, 5, 6 ve 7. sınıf ders kitaplarındaki soruların yüzde 60’a yakınının, 8. sınıf ders kitabındaki soruların ise yüzde 65’ten biraz fazlasının 2. düzeyde olduğunu göstermiştir. Üst performans düzeyindeki soruların oranının tüm sınıf düzeylerinde oldukça düşük olduğu tespit edilmiştir. Öğrenme alanları bakımından incelendiğinde ise, üst performans düzeyindeki soru oranının Dünya ve Evren öğrenme alanında diğerlerine kıyasla daha yüksek olduğu görülmüştür. En çok kazanım ve soru sayısına sahip Fiziksel Olaylar öğrenme alanındaki soruların genel olarak 2. düzeyde yığıldığı gözlenmiştir. Bu bulgular neticesinde, PISA başarısının artırılması ve fen okuryazarlık düzeyinin yükseltilmesi için, ders kitaplarındaki üst düzey sorulara yeterli sayıda yer verilmesi ve ders kitaplarının güncellenmesi; ayrıca, öğretim programının ve ülke genelinde yapılan sınavların da PISA fen okuryazarlığı kapsamında incelenmesi için çalışmalar yapılması önerilmiştir.
Anahtar Kelimeler: PISA, fen okuryazarlığı, fen okuryazarlık yeterliği, fen bilimleri ders kitapları
A study of the impact of e-learning on the health of school going adolescents in Bareilly city: A cross-sectional study
Authors: Sinha Akanksha , Khatri Vedant , Kumari Ranjeeta 
Published: September 2022

E-learning has played a major role during corona pandemic and lockdown. Gadget use and increased screen time can lead to neuropsychological and physiological problems in many children.Some of the E-learning associated health hazards can be prevented by taking few preventive measures. Therefore an endeavour has been taken up to conduct a cross-sectional study on the consequences of e-learning on the health of school going adolescents in Bareilly city of Uttar Pradesh.To find the effects of e-learning on the health of school going adolescents.And to suggest the recommendations for the prevention and control of e-learning associated health problems.Selection of study participants was done via multistage sampling. A pretested semi-structured interview schedule consisting of both open and closed ended questions was prepared. Statistical analysis was done using SPSS (version 23.0) for windows.Various health related issues were associated with e-learning like headache, body-ache, vision problems, etc.E-learning was found to be more common in males, socioeconomic class 1, Hindu religion and among students belonging to higher classes (class 8 to 10). There were some health issues found among children pursuing e-learning like headache, body-ache, vision problems, etc.E-learning health hazards can be prevented and controlled through strategic planning and implementation of health education.
Preoperative risk factors for negative clinical outcomes in acute mesenteric thrombosis in surgical ICU
Authors: Ponomareva A. D. , Leyderman I. N. , Kasherininov I. Y. , Danilov I. N. , Belikov V. L. 
Published: September 2022

Background. Acute mesenteric thrombosis (AMT) is a condition that develops with thrombosis in the vessels of the mesenteric pool, which causes hypoperfusion of the intestinal wall and leads to secondary inflammatory changes. Mortality in OMT is 80–85 %. Early diagnosis of OMT is difficult due to the lack of specific clinical signs and laboratory markers.Objective. To identify preoperative risk factors for adverse clinical outcomes in OMT.Design and Methods. A single-center retrospective observational cohort study included 47 patients diagnosed with OMT. The following patient data were analyzed: age, gender, body mass index (BMI), assessment of the patients’ condition according to the SOFA, APACHE II, EuroSCORE scales. Various laboratory parameters in the preoperative and postoperative periods were analyzed.Results. The incidence of oncological diseases and history of acute cerebrovascular accident (ACV) were significantly higher in the group of lethal outcomes of OMT than in the group of surviving patients. The correlation of higher serum levels of lactate, D-dimer, creatinine, leukocytosis and procalcitonin in the preoperative period with the development of an unfavorable clinical outcome was revealed.Conclusion. The main risk factors for the development of an unfavorable clinical outcome of mesenteric thrombosis in patients are the presence of malignant neoplasms, a history of stroke, a high level of mixed venous blood lactate, creatinine, D-dimers, procalcitonin, leukocytosis in the preoperative period.
Uważny Miron. Wątki ekokrytyczne w prozie Mirona Białoszewskiego
Authors: Bulewicz Ewelina 
Published: September 2022

Od wydania Tajnego dziennika mija właśnie dziesięć lat, a proza Mirona Białoszewskiego wciąż domaga się odkrywania w niej coraz to nowych wątków, potwierdzając tym samym jej aktualność w XXI wieku również w kontekście antropocenu. Celem mojego artykułu zatytułowanego Uważny Miron. Wątki ekokrytyczne w prozie Mirona Białoszewskiego będzie analiza i interpretacja występujących w twórczości autora Pamiętnika z powstania warszawskiego motywów ekokrytycznych, oscylujących wokół relacji autora-narratora z nie‑ludzkimi innymi. Przedmiotem moich badań uczynię dwa ważne tomy prozatorskie napisane przez Białoszewskiego w połowie lat 70. XX wieku: Konstancin oraz Chamowo, stosunkowo mało zbadane w kontekście posthumanizmu czy kategorii uważności. W referacie przedstawię stosunek autora Zawału do zwierząt, roślin oraz śmieci, który częściowo omówiła w swoich pracach Agnieszka Karpowicz. Ponadto udowodnię, iż każdy z wymienionych wątków świetnie wpisuje w aktualny dyskurs o relacji człowiek-zwierzę, natura-kultura.
Notch1 protectives against ischemic reperfusion injury via suppressing PTEN-Pink1 mediated mitochondrial dysfunction and mitophagy
Authors: Xu Qi-rong , Liu Sheng , Gong Qiang , Zhu Rong-rong , Liu Ji-chun , Zhou Xue-liang 
Published: September 2022

Abstract
Background
Myocardial ischemia/reperfusion injury is associated with adverse cardiovascular outcomes after acute myocardial infarction. However, the molecular mechanism of ischemia/reperfusion injury remains unclear. Mitochondria dysfunction have become important participants and regulators of myocardial ischemia-reperfusion injury. However, the molecular mechanisms involved in this process are still not fully understood. We previously reported that Notch1 can reduce mitochondrial lysis, reduce myocardial infarct size and inhibit ventricular remodeling. Herein, we tried to explore the downstream target of Notch1 on the mitochondrial regulation.
Methods
Ischemic/reperfusion injury rat model and hypoxia/reoxygenation cell model were constructed in this study. The expression of PTEN was detected by real-time PCR, Western Blot and immunofluorescence staining. The cell viability was analyzed by CCK-8. The apoptosis level was detected by TUNEL assay. The mitochondrial fission/fusion were analyzed by Mito-Tracker Green staining. Measurement of cardiac troponin I (cTnI), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and CK levels creatine kinase-MB (CK) were detected by ELISA Kits.
Results
We found that PETN-Pink1-Parkin signaling is inhibited by Notch1 I/R injured neonatal cardiomyocytes and hearts, thus via inhibiting the mitochondrial dysfunction and fragmentation. With the recure of PTEN or Pink1, the protective effect of Notch1 was largely diminished.
Conclusion
These results suggest that N1ICD protective against ischemic reperfusion injury via suppressing PTEN-Pink1 mediated mitochondrial dysfunction and fragmentation.