bluuebunny/crossref_metadata_2025_split huggingface dataset:
DINÁMICA DEL DESARROLLO CULTURAL Y SOCIOPOLÍTICO DE NAKUM, GUATEMALA DURANTE EL PRECLÁSICO MEDIO
Authors: Źrałka Jarosław , Hermes Bernard , Velásquez Juan Luis , Koszkul Wiesław , Wasilewski Michał 
Published: November 2022

ResumenLos resultados de investigaciones arqueológicas recientes llevadas a cabo en el sitio Nakum, ubicado en el noreste de Guatemala, indican que este centro experimentó una importante evolución cultural, sociopolítica y arquitectónica entre los horizontes pre-Mamom y Mamom (1000–300 a.C.). Las excavaciones arqueológicas permitieron documentar varios edificios y complejos fechados para este periodo, incluyendo un grupo tipo E, una cancha de juego de pelota y un baño de vapor. Asimismo, producto de las excavaciones, se obtuvo una gran colección cerámica de dicha temporalidad, la cual permite—gracias a estudios estilísticos, modales, petrográficos y fisicoquímicos—conocer con mayor detalle los cambios culturales y sociales que tuvieron lugar en el sitio durante el preclásico medio.
Influence of single nucleotide polymorphism in the IGF-1 gene on performance and conformation traits in Munjal sheep
Authors: Kumar Sandeep , Dahiya S.P. , Magotra Ankit , Ratwan Poonam , Bangar Yogesh 
Published: November 2022

SummaryGenetic polymorphism research in livestock species aims to assess genetic differences within and among breeds, primarily for conservation and development objectives. The aim of the present study was to determine the point mutation in the IGF-1 gene (g.855G>C and g.857G>A) and its association with performance traits in Munjal sheep. In total, 50 Munjal sheep were selected and the genomic DNA was isolated using the Automated Maxell RSC DNA/RNA purification system and the Maxwell RSC whole blood DNA kit. A reported set of primers was used to amplify the 294-bp fragment encompassing the targeted region, i.e. the 5′ flanking region of the IGF-1 gene. The polymerase chain reaction product of 294-bp size harbouring the g.857G>A mutation in the 5′ flanking region of the IGF-1 gene was digested with HaeII enzyme. Three possible genotypes were defined by distinct banding patterns, i.e. GG (194, 100 bp), GA (294, 194, 100 bp) and AA (294 bp) in the studied population of Munjal sheep. The genotypic and allelic frequencies of g.857G>A single nucleotide polymorphism of the IGF-1 gene indicated that the frequency of the A allele was higher in the studied population, i.e. 0.59 and the GA genotype was found to be the predominant genotype (0.66). Allele A of the IGF-1 gene was found to be associated with higher body weights and can be used in selection criteria for improving the performance of Munjal sheep. The positive effect of the IGF-1 gene on several conformational traits as observed in this study suggests that this area of the ovine IGF-I gene is particularly important and warrants further investigation on a larger population size.
Things in Themselves and the Inner/Outer Dichotomy in Kant’s Amphiboly of the Concepts of Reflection
Authors: Zanette de Araujo Rodrigo 
Published: November 2022

AbstractLangton’s (1998) and Allais’ (2015) metaphysical interpretations of Kant’s idealism have given special relevance to Kant’s analysis of the inner/outer dichotomy in the Amphiboly of the Concepts of Reflection, for they agree that this dichotomy is key to correctly grasping Kant’s distinction between appearances and things in themselves. In this article I argue that Langton’s and Allais’ accounts of Kant’s analysis of the inner/outer dichotomy have major limitations, and therefore that the text should not be read in the way they propose. In order to show these limitations, I examine the overall structure of Kant’s argument in the Amphiboly. Furthermore, I aim to establish the contribution brought by the Amphiboly to the issue of noumenal knowledge and the nature of things in themselves. Langton’s and Allais’ accounts of the relation between appearances and things in themselves as the inner nature of things not only prove to be unwarranted, but indeed to some extent opposite to what I claim to be Kant’s actual stance on things in themselves in the Amphiboly.
‘Almost None’: Women Sociologists and the Study of Women’s Crime in Early 20th-Century China and the U.S.
Authors: Montgomery Stephanie M. 
Published: November 2022

AbstractThe question of how and why women committed crimes was a topic of hot debate in 1930s Republican China. Although men sociologists during this period largely framed the origins of both men’s and women’s crime as a social issue, they nonetheless still seriously considered biological and physiological factors in women’s motivation for crime. At the same time, women sociologists who authored the two most comprehensive 1930s studies on women’s crime – Zhou Shuzhao and research team Liu Qingyu and Xu Huifang – pushed back on the connections between biology and physiology in relation to crime for both women and men. Instead, they argued unconditionally for the social causes of all crime and particular social challenges for Chinese women. Their methodologies and frameworks were especially influenced by work from the Chicago school of sociology, a department which itself produced a number of prominent women social scientists. This article traces the transnational conversation on women’s crime in Republican China through the work of U.S. sociologists who were cited by Zhou, Liu, and Xu; research by Chinese men sociologists, especially prominent sociologist Yan Jingyue; and finally, Zhou, Liu, and Xu’s own rebuttals, conclusions, and contributions in developing a theory of Chinese women’s crime. By also comparing the work of Chinese and U.S. women social scientists, this article argues that both groups pushed back, with varying strategies, on their men colleagues’ inordinate focus on criminalized women’s biology and physiology. In this way, both Chinese and U.S. women social scientists spoke into a largely male-dominated conversation and provided novel theories of women’s crime as women themselves.
A Source Apportionment and Emission Scenario Assessment of PM2.5‐ and O3‐Related Health Impacts in G20 Countries
Authors: Nawaz M. Omar , Henze Daven K. , Anenberg Susan C. , Braun Caleb , Miller Joshua , Pronk Erik 
Published: November 2022

AbstractExposure to air pollution is a leading risk factor for premature death globally; however, the complexity of its formation and the diversity of its sources can make it difficult to address. The Group of Twenty (G20) countries are a collection of the world's largest and most influential economies and are uniquely poised to take action to reduce the global health burden associated with air pollution. We present a framework capable of simultaneously identifying regional and sectoral sources of the health impacts associated with two air pollutants, fine particulate matter (PM2.5) and ozone (O3) in G20 countries; this framework is also used to assess the health impacts associated with emission reductions. This approach combines GEOS‐Chem adjoint sensitivities, satellite‐derived data, and a new framework designed to better characterize the non‐linear relationship between O3 exposures and nitrogen oxides emissions. From this approach, we estimate that a 50% reduction of land transportation emissions by 2040 would result in 251 thousand premature deaths avoided in G20 countries. These premature deaths would be attributable equally to reductions in PM2.5 and O3 exposure which make up 51% and 49% of the potential benefits, respectively. In our second application, we estimate that the energy generation related co‐benefits associated with G20 countries staying on pace with their net‐zero carbon dioxide targets would be 290 thousand premature deaths avoided in 2040; action by India (47%) would result in the most benefits of any country and a majority of these avoided deaths would be attributable to reductions in PM2.5 exposure (68%).
Significant Latitudinal Gradient of Nitrate Production in the Marine Atmospheric Boundary Layer of the Northern Hemisphere
Authors: Li Yilan , Shi Guitao , Chen Zhenlou , Lan Musheng , Ding Minghu , Li Zhengjie , Hastings Meredith G. 
Published: November 2022

AbstractAtmospheric samples collected during 2017 and 2018 Chinese Arctic Expedition cruises are used to investigate the latitudinal gradients of nitrate (NO3−) sources and production in the marine atmospheric boundary layer of the Northern Hemisphere. Both concentration and isotopic composition (δ15N, δ18O, and Δ17O) of atmospheric NO3− show significant latitudinal gradients. δ15N suggests that continental sources dominate atmospheric NO3− in both mid‐and high‐latitudes, while oceanic RONO2 emissions account for 21%–26% of the NO3− budget in mid‐latitudes. Slightly higher δ15N in high‐latitudes than in mid‐latitudes indicates insignificant isotope effects of long‐range atmospheric transport of NO3−. δ18O and Δ17O of NO3− are significantly higher in mid‐latitudes than in high‐latitudes, suggesting distinct main production pathways in the two regions. It is estimated that ∼69% of NO3− is produced via NO2 + OH in the high‐latitudes, while ∼68% of NO3− is from N2O5 + H2O and NO3 + DMS/CH pathways in mid‐latitudes.
METTL1 drives tumor progression of bladder cancer via degrading ATF3 mRNA in an m7G-modified miR-760-dependent manner
Authors: Xie Haiyun , Wang Mingchao , Yu Haifeng , Wang Huan , Ding Lifeng , Wang Ruyue , Luo Wenqin , Lu Zeyi , Zheng Qiming , Ren Liangliang , Zhou Zhenwei , Su Wenjing , Xia Liqun , Li Gonghui 
Published: November 2022

Abstract7-methylguanosine (m7G) modification is recently found to conservatively exist in RNA internal position besides mRNA caps and mediates the various RNA metabolisms. As the core confirmed transmethylase of m7G modification, METTL1 has been reported in certain human cancers. However, the role of internal m7G at miRNAs and its core writer METTL1 in bladder cancer (BCa) remains to be elucidated. Here, we demonstrated that METTL1 was indispensable for BCa proliferation and metastasis in vitro and in vivo. By combining miRNA sequencing, m7G methylated RNA immunoprecipitation (MeRIP) and RIP, we identified METTL1 promoted the processing of miR-760 in an m7G-dependent manner. Transcription sequencing suggested that METTL1 indirectly degrades tumor suppressor ATF3 mRNA mediated by miR-760. Together, we concluded a regulatory axis composed of METTL1/m7G/miR-760/ATF3 in regulating BCa progression and provided potential therapeutic targets for BCa.
Atmospheric observations suggest methane emissions in north-eastern China growing with natural gas use
Authors: Wang Fenjuan , Maksyutov Shamil , Janardanan Rajesh , Tsuruta Aki , Ito Akihiko , Morino Isamu , Yoshida Yukio , Tohjima Yasunori , Kaiser Johannes W. , Lan Xin , Zhang Yong , Mammarella Ivan , Lavric Jost V. , Matsunaga Tsuneo 
Published: November 2022

AbstractThe dramatic increase of natural gas use in China, as a substitute for coal, helps to reduce CO2 emissions and air pollution, but the climate mitigation benefit can be offset by methane leakage into the atmosphere. We estimate methane emissions from 2010 to 2018 in four regions of China using the GOSAT satellite data and in-situ observations with a high-resolution (0.1° × 0.1°) inverse model and analyze interannual changes of emissions by source sectors. We find that estimated methane emission over the north-eastern China region contributes the largest part (0.77 Tg CH4 yr−1) of the methane emission growth rate of China (0.87 Tg CH4 yr−1) and is largely attributable to the growth in natural gas use. The results provide evidence of a detectable impact on atmospheric methane observations by the increasing natural gas use in China and call for methane emission reductions throughout the gas supply chain and promotion of low emission end-use facilities.
Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome
Authors: Torres-Maravilla Edgar , Holowacz Sophie , Delannoy Johanne , Lenoir Loïc , Jacouton Elsa , Gervason Sandie , Meynier Maëva , Boucard Anne-Sophie , Carvalho Frédéric A. , Barbut Frédéric , Bermúdez-Humarán Luis G. , Langella Philippe , Waligora-Dupriet Anne-Judith 
Published: November 2022

AbstractProbiotic supplementation can help to mitigate the pathogenesis of irritable bowel syndrome (IBS) by reinforcing the intestinal barrier, and reducing both inflammation and proteolytic activity. Here, a combination of in vitro tests was performed on 33 Bifidobacterium strains as probiotic candidates for IBS. In addition to the classical tests performed, the detection of the serine protease inhibitor (serpin) enzyme capable of decreasing the high proteolytic activity found in IBS patients was included. Three serpin-positive strains were selected: Bifidobacterium breve CNCM I-5644, Bifidobacterium longum subsp. infantis CNCM I-5645 and B. longum CNCM I-5646 for their immunomodulation properties and protection of intestinal epithelial integrity in vitro. Furthermore, we found that B. breve CNCM I-5644 strain prevented intestinal hyperpermeability by upregulating Cingulin and Tight Junction Protein 1 mRNA levels and reducing pro-inflammatory markers. The ability of CNCM I-5644 strain to restore intestinal hyperpermeability (FITC-dextran) was shown in the murine model of low-grade inflammation induced by dinitrobenzene sulfonic acid (DNBS). This effect of this strain was corroborated in a second model of IBS, the neonatal maternal separation model in mice. Altogether, these data suggest that serpin-positive B. breve CNCM I-5644 may partially prevent disorders associated with increased barrier permeability such as IBS.
Study of the fatigue delamination behaviour of adhesive joints in carbon fibre reinforced epoxy composites, influence of the period of exposure to saline environment
Authors: Argüelles A. , Viña I. , Vigón P. , Lozano M. , Viña J. 
Published: November 2022

AbstractThis work analyses the fatigue delamination and fracture stress behaviour under mode I of adhesive joints made on an epoxy matrix composite material with unidirectional carbon fibre reinforcement and a commercial epoxy-based adhesive. DCB type tests (for mode I) were used with the aim to quantify the influence of the period of exposure to a degradation process in a salt spray chamber, to which the tested samples were subjected, on their fatigue behaviour. For this purpose and after a previous static characterisation of the material in which the critical values of the energy release rate for different exposure periods were determined, the levels of the energy release rate to be applied in the fatigue tests and the exposure periods to be considered (no exposure, exposure during one week and twelve weeks) and a ratio of fatigue stress levels of R = Gmin/Gmax = 0.1 were defined. From this experimental data, the G-N fatigue initiation curves and the G-da/dN growth curves were obtained. The experimental data obtained, in the fatigue initiation phase of the delamination process, have been treated by means of a probabilistic model based on a Weibull distribution, the application of models of these characteristics has allowed a better interpretation of the experimental results obtained. The most relevant result of the work is that, in general, the fatigue limits obtained for the adhesive joint, under mode I fracture, when subjected to a degradation process in a saline environment, do not translate into a relevant loss of its resistance capacity against this fatigue delamination phenomenon, in its initiation phase. On the other hand, the crack growth rates of the material subjected to different periods of exposure to a saline environment are similar and higher than those obtained for the material without exposure.
High-flux neutron generation by laser-accelerated ions from single- and double-layer targets
Authors: Horný Vojtěch , Chen Sophia N. , Davoine Xavier , Lelasseux Vincent , Gremillet Laurent , Fuchs Julien 
Published: November 2022

AbstractContemporary ultraintense, short-pulse laser systems provide extremely compact setups for the production of high-flux neutron beams, such as those required for nondestructive probing of dense matter, research on neutron-induced damage in fusion devices or laboratory astrophysics studies. Here, by coupling particle-in-cell and Monte Carlo numerical simulations, we examine possible strategies to optimise neutron sources from ion-induced nuclear reactions using 1-PW, 20-fs-class laser systems. To improve the ion acceleration, the laser-irradiated targets are chosen to be ultrathin solid foils, either standing alone or preceded by a plasma layer of near-critical density to enhance the laser focusing. We compare the performance of these single- and double-layer targets, and determine their optimum parameters in terms of energy and angular spectra of the accelerated ions. These are then sent into a converter to generate neutrons via nuclear reactions on beryllium and lead nuclei. Overall, we identify configurations that result in neutron yields as high as $$\sim 10^{10}\,{\mathrm{n}}\,{\mathrm{sr}}^{-1}$$

∼

10
10

n

sr

-
1

in $$\sim 1$$

∼
1

-cm-thick converters or instantaneous neutron fluxes above $$10^{23}\,{\mathrm{n}}\,{\mathrm{cm}}^{-2}\,{\mathrm{s}}^{-1}$$

10
23

n

cm

-
2

s

-
1

at the backside of $$\lesssim 100$$

≲
100

-$$\upmu$$
μ
m-thick converters. Considering a realistic repetition rate of one laser shot per minute, the corresponding time-averaged neutron yields are predicted to reach values ($$\gtrsim 10^7\,{\mathrm{n}} \,{\mathrm{sr}}^{-1}\,{\mathrm{s}}^{-1}$$

≳

10
7

n

sr

-
1

s

-
1

) well above the current experimental record, and this even with a mere thin foil as a primary target. A further increase in the time-averaged yield up to above $$10^8\,{\mathrm{sr}}^{-1}\,{\mathrm{s}}^{-1}$$

10
8

sr

-
1

s

-
1

is foreseen using double-layer targets.
Tracheostomy decannulation rates in Japan: a retrospective cohort study using a claims database
Authors: Ishizaki Miho , Toyama Mayumi , Imura Haruki , Takahashi Yoshimitsu , Nakayama Takeo 
Published: November 2022

AbstractDespite the exponential increase in the use of tracheostomy worldwide, rates of tracheostomy decannulation are unknown. We conducted a retrospective cohort study to investigate tracheostomy decannulation rates among adult patients over a two-year period and explored factors associated with prolonged tracheostomy. A health insurance claims database including 3,758,210 people in Japan was used. The primary outcome was time to decannulation. Assessed patient and hospital factors included age, sex, emergency endotracheal intubation, disease, and hospital size. A total of 917 patients underwent tracheostomy, and 752 met the eligibility criteria. Decannulation rates were 40.8% (95% confidence interval 36.8–44.9) at 3 months, 63.9% (58.4–69.0) at 12 months, and 65.0% (59.2–70.3) at 24 months. Hazard ratios of patient and hospital factors for tracheostomy decannulation were 0.44 for age (65–74 years) (95% confidence interval 0.28–0.68), 0.81 (0.63–1.05) for female sex, and 0.59 (0.45–0.76) for emergency endotracheal intubation. Cerebrovascular disease, head injuries, and cardiac arrest had lower hazard ratios compared to other diseases. Decannulation rates among adult patients in Japan increased rapidly up to 3 months after tracheostomy, reaching a plateau after 12 months. Older age, female sex, emergency endotracheal intubation, cerebrovascular disease, head injuries, and cardiac arrest were associated with prolonged tracheostomy.
The release of petroleum hydrocarbons from a saline-sodic soil by the new biosurfactant-producing strain of Bacillus sp.
Authors: Kalvandi Sahar , Garousin Hamidreza , Pourbabaee Ahmad Ail , Farahbakhsh Mohsen 
Published: November 2022

AbstractAdsorption of old-aged petroleum hydrocarbons to the soil solid phase, which causes biosurfactant loss of performance, is among the limiting factors for the remediation of the saline-sodic soils contaminated with petroleum. Therefore, to find a functional biosurfactant in oil-contaminated saline-sodic soils, the efficiency of 39 bacteria isolated from petroleum-contaminated soils was evaluated. The strains were cultured in the Bushnell–Haas medium, and the produced biosurfactants and bioemulsifiers in this medium were extracted using chloroform/methanol and ethyl acetate extraction methods, respectively. Their partial purification was performed by column chromatography, and eventually, their performance in releasing TPH from the contaminated soil was evaluated. The soil test results revealed that the highest TPH releases due to the effects of the biosurfactants and bioemulsifier produced from SHA302, SH21, and SH72 isolates were 42.4% ± 0.2, 21.6% ± 0.15 and 24.3% ± 0.91, respectively. Based on the 16S rRNA gene sequence, the SHA302 strain showed 93.98% phylogenetic similarity with Bacillus pumilus strain ATCC 7061. The Fourier transform infrared spectroscopy and thin-layer chromatography results proved that the biosurfactants produced by isolates SHA302, SH21 and SH72 showed lipopeptide, glycolipoprotein and glycoprotein natures, respectively. The performance of the biosurfactant produced by SHA302 isolate indicated that it could be used as a good candidate for releasing TPH from saline-sodic soils with old contamination and facilitating the degradation of hydrocarbons.
The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea
Authors: He Wenxuan , Burwood George , Porsov Edward V. , Fridberger Anders , Nuttall Alfred L. , Ren Tianying 
Published: November 2022

AbstractThe prevailing theory of cochlear function states that outer hair cells amplify sound-induced vibration to improve hearing sensitivity and frequency specificity. Recent micromechanical measurements in the basal turn of gerbil cochleae through the round window have demonstrated that the reticular lamina vibration lags the basilar membrane vibration, and it is physiologically vulnerable not only at the best frequency but also at the low frequencies. These results suggest that outer hair cells from a broad cochlear region enhance hearing sensitivity through a global hydromechanical mechanism. However, the time difference between the reticular lamina and basilar membrane vibration has been thought to result from a systematic measurement error caused by the optical axis non-perpendicular to the cochlear partition. To address this concern, we measured the reticular lamina and basilar membrane vibrations in the transverse direction through an opening in the cochlear lateral wall in this study. Present results show that the phase difference between the reticular lamina and basilar membrane vibration decreases with frequency by ~ 180 degrees from low frequencies to the best frequency, consistent with those measured through the round window. Together with the round-window measurement, the low-coherence interferometry through the cochlear lateral wall demonstrates that the time difference between the reticular lamina and basilar membrane vibration results from the cochlear active processing rather than a measurement error.