bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression and potential immune involvement of cuproptosis in kidney renal clear cell carcinoma
Authors: Liu Hengrui 
Published: June 2022

Abstract
Cuproptosis is a newly identified programmed cell death pathway mediated by intracellular free copper. Three anti-cuproptosis genes (MTF1, GLS, and CDKN2A) and seven pro-cuproptosis genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, and PDHB) genes with an anti-cuproptosis copper exporter ATP7B and a pro-cuproptosis copper importer SLC31A1 were studied in this study for a better insight into the role of cuproptosis in cancers. Our preliminary screening analysis based on these 12 cuproptosis genes across more than 9000 samples of 33 types of solid tumors identified kidney renal clear cell carcinoma (KIRC) as a cancer type most likely to be affected by cuproptosis. This study analyzed the multi-omic data to explore the cancer-noncancer expression pattern and potential immune involvement of the cuproptosis pathway in KIRC. We clustered the TCGA KIRC samples based on the cuproptosis gene set to study the role of cuproptosis in the KIRC immune and found the potential value of cuproptosis signature for immunotherapy prognosis. We concluded that cuproptosis might affect KIRC and had potential value in immune therapy. We hope this study can contribute to the application of cuproptosis in the clinical therapy of KIRC.
Prevalence of emergence delirium and associated factors among old-age patients who underwent elective surgery in the Teaching Hospitals of Ethiopia, Ethiopia, 2021. A multicenter prospective observational study
Authors: Tageza Tajera 
Published: June 2022

Abstract
Background
Emergence Delirium is a common and serious post-operative complication in surgical patients, especially in the old-age. It occurs at any time in the perioperative period, during or immediately following emergence from general anesthesia. Unfortunately, it is highly associated with post-operative complications such as decrease in functional capacity, prolonged hospital stay, an increase in health care costs and morbidity and mortality. The goal of this study was to determine the prevalence of emergence delirium and associated factors among old-age patients who underwent elective surgery in the Teaching Hospitals of Ethiopia at post anesthesia care unit, 2021.
Methods
A multi-center prospective observational study was conducted at the post-anesthetic care unit of four teaching hospitals in Ethiopia. Old-age surgical patients admitted to Post-anesthesia Care Unit who underwent elective surgery in the four Teaching Hospitals of Ethiopia were selected by using simple random sampling. Pretested structured questionnaire was used to collect data. Data were entered in to Epidata (version 4.6) and exported to the SPSS (version 25.0). Binary logistic regression was used to identify factors independently associated with emergence delirium.
Results
Out of 384 old-age patients included in the study with 100% response rate, the Prevalence of emergence delirium was 27.6%. Preoperative low hemoglobin levels (AOR: 2.0, 95%CI; 1.77–3.46), opioids (AOR: 8.0, 95%CI; 3.22–27.8) and anti-cholinergic premedications (AOR: 8.5, 95%CI; 6.85–17.35), and post-operative pain (AOR: 3.10, 95CI; 2.07–9.84) at PACU were independently associated with emergence delirium.
Conclusion
The Prevalence of emergence delirium was high. Old-age patients who were premedicated with anti-cholinergic and opioids, those patients who had low pre-operative hemoglobin and post-operative pain were independently associated with emergence delirium. Adequate pre-operative optimization and post-operative analgesia may reduce the Prevalence of emergence delirium.
Resilience in health workers: The role of social support and calling
Authors: Koamesah Grace Tesabela , Virlia Stefani , Musa Muwaga 
Published: June 2022

Health workers are professionals with high exposure to various types of stress; therefore, they need resilience to survive in their profession. This research aims to test the effect of social support and calling on resilience in health workers. It is a quantitative-correlational study conducted cross-sectionally. The instruments used were the Connor-Davidson Resilience Scale, Multidimensional Support Scale, and Calling Scale. Snowball sampling was used to identify participants, consisting of 113 health workers in East Nusa Tenggara province, Indonesia. The data were analyzed with multiple linear regression techniques. Significant effects of social support and calling were found on resilience (p .01, F = 34.224), with calling shown to have more significant impact (p .01, F = 60.685) and 35.3% effective contribution. Amongst the types of social support, coworkers make the most significant contribution of 11.8% (p .01, F = 14.816), followed by family members at 9.6% (p .01, F = 11.752). On the other hand, social support from supervisors does not affect resilience (p .05, F = 0.904). Health workers should seek the social support they need proactively, and prospective health workers should consider their calling when choosing a career.
A Comparative Study on the Application of Text Mining in Cybersecurity
Authors: Barik Kousik , Misra Sanjay , Konar Karabi , Kaushik Manju , Ahuja Ravin 
Published: June 2022

Aims:This paper aims to conduct a Systematic Literature Review (SLR) of the relative applications of text mining in cybersecurity.Objectives:worldwide has been attributed to a change in the different activities associated with cyber security and demands a high automation level.Methods:In the cyber security domain, text mining is an alternative for improving the usefulness of various activities that entail unstructured data. This study searched databases of 516 papers from 2015 to 21. Out of which 75 papers are selected for analysis. A detailed evaluation of the selected studies employs source, techniques, and information extraction on cyber security applications.Results:This study extends gaps for future study such as text processing, availability of datasets, innovative methods, intelligent text mining.Conclusion:This study concludes with interesting findings of employing text mining in cybersecurity applications; the researchers need to exploit all related techniques and algorithms in text mining to detect and protect the organization from Cybersecurity applications.
Caritative Innovation: Fundraising and Crowdfunding
Authors: Semenov I. A. 
Published: June 2022

The relevance of the study is due to the fact that the process of digitalization is integrated into the entire set of sectors of the national economy, which is directly related to maintaining the proper level of well-being of the population. Charity, including caritative activities, is also subject to digitalization. The author considers fundraising and crowdfunding as a tool for digital socially transformative investment. The elements and the mechanism of financial transactions for online charitable donation are presented, their functionality is described in symbiosis with web services.The purpose is to identify and structure the essential features of innovative forms of caritative activity: fundraising and crowdfunding.Objectives: to reveal the concepts: "innovative forms of caritative activity", "fundraising" and "crowdfunding"; to analyze the algorithm of functioning of innovative forms of caritative activity, as well as to predict the ways of their further development in the future.Methodology. The methodological basis of the study is based on the ontological, socio-economic approach, as well as other and other approaches, generalized by the dialectical method, in the study of the innovative field of caritative activity.Result. Result of the work carried out, the essence, as well as the mechanism for implementing innovative forms of caritative activity, is considered, a model of interaction between participants in fundraising and crowdfunding relations is derived. The socio-philosophical aspect of caritative activity is presented.Conclusions. Socially transformative investment is an important element of the digitalization of philanthropy, which is prominently expressed in the form of fundraising and crowdfunding. With the successful implementation of innovative forms of caritative activity and their introduction into practice, the speed of solving financial problems related to fundraising, as well as the completeness of coverage of the audience interested in caritative assistance, significantly increases.
The Ontological Status of an Artistic Image on the Example of Acting (II): Creation of a Stage Image
Authors: Sinitsyna T. A. 
Published: June 2022

Relevance. In this work we continue to develop the range of problems raised in the first article, which shows that the ontological status of an artistic image is made up of its "materiality", sign-symbolic and metaphysical components. An urgent problem for the theory and philosophy of the theater is the development and substantiation of the processes of synthesis of the imagination and physicality of the actor in practice, in the embodiment of the stage image.The purpose is on the basis of the philosophical and methodological analysis of theatrical practice we are going to show that the embodiment of a stage image in a theatrical performance is possible only under the condition of a joint maximum concentration of perception, both by the actor and the spectator.Objectives: on the basis of various theatrical concepts and ideas of quantum-synergetic anthropology we plan to consider the formation of a stage image in practice; to reveal the relationship of the ontological status of this image with the problem of the unity of consciousness and body; to identify the features of the audience's perception of the game and the unique characteristics of theatrical practice as a post-non-classical practice.Methodology. Historical and philosophical approach to the problems of perception and the correlation of corporality and consciousness; philosophical reflection, hermeneutical method, methodology of generalized corporeality in quantum-synergetic anthropology.Results. The concept of a creative impulse of a theatrical action is introduced as an interpretation of the concept of A. Bergson's creative impulse in theatrical practice. As a result of the study, it was found that the completeness of the perception of the stage image mainly depends on the integrity of the states of the actor's generalized corporeality in the acts of the "creative impulse" of the theatrical action.Conclusions. The theatrical production gives the viewer much less space for interpretation (compared to other non-stage art forms) in the process of being captured by the general action, although, of course, it does not completely deprive him of this freedom. The ontological status of the stage image represents the integrity of the processes of the generalized corporality of the actor and the audience's perception.
La Aplicación de las Técnicas de Programación Neurolingüística para Aumentar la Motivación Estudiantil en la Educación de Adultos
Authors: Ruiz Santiago Silvia 
Published: June 2022

La pérdida motivacional estudiantil es un hecho que enfrentan hoy día los sistemas educativos a nivel mundial. Conocer cómo los líderes educacionales pueden ayudar a los educandos a activar su interés mediante la instrucción será esencial. El objetivo residirá en conocer cómo funciona el sistema neurológico, lingüístico y cómo se programan los pensamientos, para realizar una reestructuración cognitiva en el estudiante, logrando mejorar su motivación y, por ende, alcanzar tanto los objetivos estudiantiles, de los docentes como los institucionales. Por lo tanto, la programación neurolingüística en el aprendizaje de una segunda lengua en la población de adultos va a permitir a través de sus técnicas ayudar al alumno en el proceso instructivo lingüístico, consiguiendo consecuentemente su motivación. Se concluye con la importancia de la puesta en práctica de la programación neurolingüística, así como de sus técnicas con el fin de conseguir el éxito estudiantil.
Formación docente en Ciencia y Tecnología desde un escenario alternativo de educación
Authors: Ariza-Porras Angie Paola , Franco-Avellaneda Manuel , Quiroga-Monroy Jesus David 
Published: June 2022

El potencial de la ciudad como entorno y agente educativo es reconocido cada vez con más fuerza en las agendas de las políticas públicas. Este artículo explora la manera en la que las ciencias pueden ofrecer herramientas para apropiar la ciudad de forma más equitativa y participativa e imaginar en ella nuevas posibilidades, reconociendo el rol protagónico que tienen en esta tarea los y las docentes. Para esto se exponen los aprendizajes de la Ruta de Formación en Ciencia y Tecnología, un programa de formación docente realizado por el museo interactivo Maloka y la Secretaría de Educación de Bogotá, durante el año 2019.
Getting to Proportionality: The Trouble with Sentencing for Possession of Child Pornography in Ontario
Authors: Dauda Carol , McNabb Danielle 
Published: June 2022

In this article we examine sentencing in 14 Ontario cases of possession of child pornography between 2007 and 2017 with the purpose of understanding the sentencing process in relation to the fundamental principle of proportionality and other principles employed to arrive at a fair, individualizing process as set out in Canadian sentencing law. In all cases the offenders are charged with possession only and have no prior offences. We situate these cases within the context of sentencing reform in general and child pornography law specifically, including the evolution of mandatory minimums, as they have evolved in both legislation and case law. Our cases cover two periods of mandatory minimums, 45 days and six months. Although we consider numerical sentences, probation and ancillary conditions awarded when examining our cases, we are interested in the process of determining the sentencing components. We analyse this process in two ways: by observing the judicial reasoning in calculating the seriousness of the crime and the blameworthiness of the offender and the balancing of other purposes and principles, particularly rehabilitation and parity; and, by considering three pairings of cases, each with similar quantity and quality of images, to compare the calculation of risk and its effect on determining the blameworthiness of the particular offender. Our findings reveal a polarization in judicial reasoning between a punitive process in which overemphasis of denunciation and deterrence and extreme versions of the reasoned apprehension of harm add weight to the seriousness of the crime on a par with contact abuse, and a more tempered and restrained one in which possession is considered on its own and other purposes and principles are weighed, such as rehabilitation and parity, to arrive at a more individualizing process. Mandatory minimums are no constraint as sentencing is much lengthier, especially under the 45-day mandatory minimum. In pairing like cases in terms of collections of images and videos we find a very subjective process in the calculating of risk in which like offenders are treated differently in terms of assessments of blameworthiness, based on questionable forensic methods and assumptions. Finally, we note the resources involved in investigative time, incarceration and the supervising of probation as well as lengthy ancillary conditions that may last decades after sentencing.
The Legal Regulation of Sadomasochism and the So-Called “Rough Sex Defence”
Authors: Craig Elaine 
Published: June 2022

The focus of this article is on the judicial application of Canada’s sexual assault doctrine in the context of the so called ‘rough sex defence’. Canadian criminal courts have seen an increased prevalence of legal narratives about S/M in recent years. In particular, courts are increasingly confronted with individuals who defend themselves against allegations of sexual assault by claiming that the impugned acts constituted consensual S/M or ‘rough sex’. The analysis is aimed at illustrating the way in which courts may fail to properly apply legal doctrine because of a problematic approach to the S/M context in which allegations arose.
Pelaksanaan Tanggung Jawab Orang Tua Terhadap Anak Pasca Perceraian di Wilayah Hukum Pengadilan Negeri Jambi
Authors: Sinaga Lolanda , Hasan Umar , Permono Permono 
Published: June 2022

The purpose of this study is to know and analyze the responsibilities of parents towards children after divorce in the jurisdiction of the Jambi District Court. 2. To find out and analyze the obstacles faced in implementing the responsibilities of parents towards children after the divorce in the Jurisdiction of the Jambi District Court. The method used is empirical juridical research type. The formulation of the problem under study regarding the responsibilities of parents towards post-divorce children in the jurisdiction of the Jambi District Court 1. How to implement the responsibilities of parents towards post-divorce children in the jurisdiction of the Jambi District Court; 2. Whatever is the obstacle in the implementation of parental responsibilities towards children after divorce in the jurisdiction of the Jambi District Court. The results of the study show that 1. the implementation of parental responsibilities towards children after divorce in the jurisdiction of the Jambi District Court is not fully implemented 2. the constraints in the implementation of parental responsibilities towards children after divorce in the jurisdiction of the Jambi District Court are the lack of awareness of people parents will have a good future for children, a factor in the inability of parents to finance the financial needs of children.
Keywords: Responsibility of Parents, Children, Divorce.

Abstrak
Tujuan dari penelitian ini adalah 1.untuk mengetahui dan menganalisis tanggung jawab orang tua terhadap anak pasca perceraian di wilayah hukum Pengadilan Negeri Jambi. 2. Untuk mengetahui dan menganalisis kendala yang dihadapi dalam pelaksanaan tanggung jawab orang tua terhadap anak pasca terjadinya perceraian di Wilayah Hukum Pengadilan Negeri Jambi. Metode yang digunakan adalah tipe penelitian yuridis empiris. Adapun perumusan masalah yang dikaji mengenai Bagaimana tanggung jawab orang tua terhadap anak pasca perceraian di wilayah hukum Pengadilan Negeri Jambi 1. Bagaimana pelaksanaan tanggung jawab orang tua terhadap anak pasca perceraian di wilayah hukum Pengadilan Negeri Jambi; 2. Apasaja yang menjadi kendala dalam pelaksanaan tanggung jawab orang tua terhadap anak pasca terjadinya perceraian di wilayah hukum Pengadilan Negeri Jambi. Hasil dari penelitian menunjukkan bahwa 1. pelaksanaan tanggung jawab orang tua terhadap anak pasca perceraian di wilayah hukum Pengadilan Negeri Jambi tidak dilaksanakan secara penuh 2. kendala dalam pelaksanaan tanggung jawab orang tua terhadap anak pasca terjadinya perceraian di wilayah hukum Pengadilan Negeri Jambi yaitu kurangnya kesadaran orang tua akan masa depan yang baik bagi anak, faktor ketidakmampuan orang tua untuk membiayai kebutuhan keuangan bagi anak.
Kata Kunci : Tanggung Jawab Orang Tua, Anak, Perceraian.
Perjanjian Penyediaan Air Minum Antara SPAM dengan Pelanggan Di Kabupaten Musi Rawas Utara
Authors: Saputra Rolan , Hosen M. , Idris Isran 
Published: June 2022

Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pelaksanaan hak dan kewajiban para pihak dalam perjanjian Penyediaan Air Minum antara SPAM Kecamatan Rawas Ulu dengan pelanggannya di Kabupaten Musi Rawas Utara; dan yang kedua untuk mengetahui dan menganalisis penyelesaian permasalahan yang dihadapi dalam perjanjian Penyediaan Air Minum antara SPAM Kecamatan Rawas Ulu dengan pelanggannya di Kabupaten Musi Rawas Utara. Metode yang digunakan adalah tipe penelitian yuridis empiris. Hasil penelitian menunjukkan bahwa pelaksanaan hak dan kewajiban para pihak dalam perjanjian penyediaan air minum antara SPAM Kecamatan Rawas Ulu dengan pelanggannya di Kabupaten Musi Rawas Utara belum sepenuhnya dilaksanakan. Hal ini dikarenakan beberapa kondisi sebagai berikut pelanggan SPAM yang banyak melakukan penunggakan pembayaran, pihak SPAM yang tidak memperhatikan beberapa pelanggan tidak menerima aliran air SPAM secara lancar dan kualitas air yang baik; penyelesaian permasalahan yang dihadapi dalam perjanjian Penyediaan Air Minum antara SPAM Kecamatan Rawas Ulu dengan pelanggannya di Kabupaten Musi Rawas Utara berupa apabila dirugikan oleh SPAM Kecamatan Rawas Ulu dalam pemanfaatan jasa air bersihya itu Konsumen dapat menyampaikan keluhannya melalui nomor telepon atau datang sendiri ke kantor SPAM Kecamatan Rawas Ulu.
Kata kunci: Perjanjian; Hak; Kewajiban

Abstract
This study aims to determine and analyze the implementation of the rights and obligations of the parties in the Drinking Water Supply agreement between SPAM Rawas Ulu District and its customers in North MusiRawas Regency; and the second to find out and analyze the resolution of problems encountered in the Drinking Water Supply agreement between SPAM Rawas Ulu District and its customers in North MusiRawas Regency. The method used is empirical juridical research type. The results showed that the implementation of the rights and obligations of the parties in the drinking water supply agreement between SPAM Rawas Ulu District and its customers in North MusiRawas Regency had not been fully implemented. This is due to several conditions as follows: SPAM customers who make a lot of arrears in payment, the SPAM who do not pay attention to some customers do not receive SPAM water flow smoothly and good water quality; resolution of problems encountered in the Drinking Water Supply agreement between SPAM Rawas Ulu District and its customers in North MusiRawas Regency in the form of if harmed by the SPAM Rawas Ulu District in the utilization of clean water services. Consumers can submit their complaints through telephone numbers or come in person to the SPAM office in Rawas Ulu District.

Keywords: Pact; Agreement; Right; Duty