bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can false denials turn fact into fiction? The effect of false denials on memory for self-performed actions
Authors: Bücken Charlotte A. , Otgaar Henry , Mangiulli Ivan , Ramakers Niki , Merckelbach Harald 
Published: June 2022

AbstractWe examined the mnemonic effects of falsely denying a self-performed action. Specifically, participants (N = 30) performed, imagined, or received no instruction about 24 action statements (e.g., “cross your arms”). Next, their memory for whether they had performed, imagined, or did nothing (i.e., received no instructions) with these actions was tested. Subsequently, participants were instructed to repeatedly deny an action they had performed (false denial) and to repeatedly claim to have performed an action they had only imagined (false admission). In a final sorting memory task, 54% (n = 16) of participants erroneously indicated, after false admissions, that they had performed the imagined action. None of the participants indicated that they had only imagined an action after false denials, showing that it might be difficult to forget a performed action, even after repeatedly denying it. The current experiment sets the stage for future research to investigate why it seems to be difficult to forget performed actions.
Functional connectivity correlates of reduced goal-directed behaviors in behavioural variant frontotemporal dementia
Authors: Godefroy Valérie , Batrancourt Bénédicte , Charron Sylvain , Bouzigues Arabella , Bendetowicz David , Carle Guilhem , Rametti-Lacroux Armelle , Bombois Stéphanie , Cognat Emmanuel , Migliaccio Raffaella , Levy Richard 
Published: June 2022

AbstractWe explored the resting state functional connectivity correlates of apathy assessed as a multidimensional construct, using behavioral metrics, in behavioral variant frontotemporal dementia (bvFTD). We recorded the behavior of 20 bvFTD patients and 16 healthy controls in a close-to-real-life situation including a free phase (FP—in which actions were self-initiated) and a guided phase (GP—in which initiation of actions was facilitated by external guidance). We investigated the activity time and walking episode features as quantifiers of apathy. We used the means ((FP + GP)/2) and the differences (FP-GP) calculated for these metrics as well as measures by questionnaires to extract apathy dimensions by factor analysis. We assessed two types of fMRI-based resting state connectivity measures (local activity and seed-based connectivity) and explored their relationship with extracted apathy dimensions. Apathy in bvFTD was associated with lower time spent in activity combined with walking episodes of higher frequency, lower acceleration and higher duration. Using these behavioral metrics and apathy measures by questionnaires, we disentangled two dimensions: the global reduction of goal-directed behaviors and the specific deficit of self-initiation. Global apathy was associated with lower resting state activity within prefrontal cortex and lower connectivity of salience network hubs while the decrease in self-initiation was related to increased connectivity of parietal default-mode network hubs. Through a novel dimensional approach, we dissociated the functional connectivity correlates of global apathy and self-initiation deficit. We discussed in particular the role of the modified connectivity of lateral parietal cortex in the volitional process.
The prognostic role of PSMD14 in head and neck squamous cell carcinoma
Authors: Schnoell Julia , Scheiflinger Alexandra , Al-Gboore Sega , Kadletz-Wanke Lorenz , Kenner Lukas , Heiduschka Gregor , Jank Bernhard J. 
Published: June 2022

Abstract
Purpose
PSMD14 is an essential protein for proteasomal degradation. Inhibition of this protein disrupts homeostasis and inhibits cancer cell viability. Overexpression of PSMD14 was associated with advanced cancer characteristics and a worse prognosis in various carcinomas. This study aimed to analyze PSMD14 copy number variation, mRNA and protein expression in HNSCC, and its role as an independent prognostic biomarker.

Methods
PSMD14 mRNA expression and copy number variations were analyzed in “The Cancer Genome Atlas (TCGA)” in 510 patients. Protein expression was evaluated using immunohistochemistry in a second cohort including 115 patients. PSMD14 levels were analyzed for correlation with clinicopathological data, overall and disease-free survival.

Results
PSMD14 mRNA expression and copy number variation were high in 44 and 50% of patients, respectively. Protein expression of PSMD14 was high in 56%. In both cohorts, high PSMD14 levels were associated with advanced staging. High PSMD14 mRNA expression was additionally associated with a worse prognosis in univariable analysis. However, after correction for possible confounders, PSMD14 mRNA was not an independent prognostic marker.

Conclusion
PSMD14 is commonly expressed in HNSCC patients and associated with advanced stages. High expression of PSMD14 mRNA was associated with a worse outcome. However, this may be a result of the association of PSMD14 with poor prognosticators. Based on our study, further evaluation of PSMD14 as a prognostic marker and potential therapeutic target is warranted.
Optimal design of fuzzy-PID controller for automatic generation control of multi-source interconnected power system
Authors: Barakat Mohamed 
Published: June 2022

AbstractThis paper suggests a fuzzy logic controller (FLC) structure from seven membership functions (MFs) and its input–output relationship rules to design a secondary controller to reduce load frequency control (LFC) issues. The FLC is coupled to a proportional–integral–derivative (PID) controller as the proposed FPID controller, which is tuned by an optimized water cycle algorithm (WCA). The proposed WCA: FPID scheme was implemented with two models from the literature under the integral time absolute error cost function. Initially, a two-area non-reheat unit was implemented, and the gains of PID and FPID controllers were adjusted to verify the suitability of WCA in solving LFC issues. Then, in order to identify the robustness of the closed-loop system, sensitivity analysis is carried out. Additionally, a two-area non-reheat unit was tested under the governor dead band nonlinearity. To guarantee the suitability of the proposed FPID controller, a model with a mixture of power plants, such as reheat, hydro, and gas unit in each area was carried out with and without the HVDC link, which can increase practical issues with LFC. The proposed controller's robustness was studied for all models under numerous scenarios, step load perturbations (SLP), and different objective functions. Simulation results proved that the proposed FPID controller provided superior performance compared to recently reported techniques in terms of peaks and settling time.
Extended Cognition and Constructive Empiricism
Authors: Baker Kane 
Published: June 2022

AbstractAccording to constructive empiricists, accepting a scientific theory involves belief only that it is true of the observable world, where observability is defined in terms of what is detectable by the unaided senses. On this view, scientific instruments are machines that generate new observable data, but this data need not be interpreted as providing access to a realm of phenomena beyond what is revealed by the senses. A recent challenge to the constructive empiricist account of instruments appeals to the extended mind thesis, according to which cognitive processes are sometimes constituted not just by brain activity, but can extend into the rest of the body and the surrounding environment. If this is right, scientific instruments may, in the right circumstances, literally become part of our perceptual processes. In this article, I examine this extended perception argument, and I find that it fails for the vast majority of scientific instruments. Even if the extended mind thesis is accepted, the constructive empiricist can draw a line between observables and unobservables that makes very few concessions to the realist.
A relic of design: against proper functions in biology
Authors: Ratti Emanuele , Germain Pierre-Luc 
Published: June 2022

AbstractThe notion of biological function is fraught with difficulties—intrinsically and irremediably so, we argue. The physiological practice of functional ascription originates from a time when organisms were thought to be designed and remained largely unchanged since. In a secularized worldview, this creates a paradox which accounts of functions as selected effect attempt to resolve. This attempt, we argue, misses its target in physiology and it brings problems of its own. Instead, we propose that a better solution to the conundrum of biological functions is to abandon the notion altogether, a prospect not only less daunting than it appears, but arguably the natural continuation of the naturalisation of biology.
Particularizing Nonhuman Nature in Stakeholder Theory: The Recognition Approach
Authors: Kortetmäki Teea , Heikkinen Anna , Jokinen Ari 
Published: June 2022

AbstractStakeholder theory has grown into one of the most frequent approaches to organizational sustainability. Stakeholder research has provided considerable insight on organization–nature relations, and advanced approaches that consider the intrinsic value of nonhuman nature. However, nonhuman nature is typically approached as an ambiguous, unified entity. Taking nonhumans adequately into account requires greater detail for both grounding the status of nonhumans and particularizing nonhuman entities as a set of potential organizational stakeholders with different characteristics, vulnerabilities, and needs. We utilize the philosophical concept of ‘recognition’ to provide a normative underpinning for stakeholder theorizing on nonhuman nature in both universal and difference-sensitive terms. We discuss how the status model of recognition helps identify relevant nonhumans as organizational stakeholders, establish respect, and particularize nonhumans in their distinctiveness and in partner-like ways. The implications of the recognition approach for stakeholder research are explicated with an illustrative case that exemplifies the recognition and particularization of nonhuman nature. We contribute to stakeholder research on nonhuman nature by suggesting that recognition provides a conceptual tool for theorizing the stakeholder status and particularization of nonhuman nature. Thereby, this article reduces anthropocentric bias and increases the capacity of stakeholder theorizing to confront the challenges of the ecological crisis.
Influence of local aortic calcification on periaortic adipose tissue radiomics texture features—a primary analysis on PCCT
Authors: Tharmaseelan Hishan , Froelich Matthias F. , Nörenberg Dominik , Overhoff Daniel , Rotkopf Lukas T. , Riffel Philipp , Schoenberg Stefan O. , Ayx Isabelle 
Published: June 2022

AbstractPerivascular adipose tissue is known to be metabolically active. Volume and density of periaortic adipose tissue are associated with aortic calcification as well as aortic diameter indicating a possible influence of periaortic adipose tissue on the development of aortic calcification. Due to better spatial resolution and signal-to-noise ratio, new CT technologies such as photon-counting computed tomography may allow the detection of texture alterations of periaortic adipose tissue depending on the existence of local aortic calcification possibly outlining a biomarker for the development of arteriosclerosis. In this retrospective, single-center, IRB-approved study, periaortic adipose tissue was segmented semiautomatically and radiomics features were extracted using pyradiomics. Statistical analysis was performed in R statistics calculating mean and standard deviation with Pearson correlation coefficient for feature correlation. For feature selection Random Forest classification was performed. A two-tailed unpaired t test was applied to the final feature set. Results were visualized as boxplots and heatmaps. A total of 30 patients (66.6% female, median age 57 years) were enrolled in this study. Patients were divided into two subgroups depending on the presence of local aortic calcification. By Random Forest feature selection a set of seven higher-order features could be defined to discriminate periaortic adipose tissue texture between these two groups. The t test showed a statistic significant discrimination for all features (p < 0.05). Texture changes of periaortic adipose tissue associated with the existence of local aortic calcification may lay the foundation for finding a biomarker for development of arteriosclerosis.
The obesity-breast cancer link: a multidisciplinary perspective
Authors: Devericks Emily N. , Carson Meredith S. , McCullough Lauren E. , Coleman Michael F. , Hursting Stephen D. 
Published: June 2022

AbstractObesity, exceptionally prevalent in the USA, promotes the incidence and progression of numerous cancer types including breast cancer. Complex, interacting metabolic and immune dysregulation marks the development of both breast cancer and obesity. Obesity promotes chronic low-grade inflammation, particularly in white adipose tissue, which drives immune dysfunction marked by increased pro-inflammatory cytokine production, alternative macrophage activation, and reduced T cell function. Breast tissue is predominantly composed of white adipose, and developing breast cancer readily and directly interacts with cells and signals from adipose remodeled by obesity. This review discusses the biological mechanisms through which obesity promotes breast cancer, the role of obesity in breast cancer health disparities, and dietary interventions to mitigate the adverse effects of obesity on breast cancer. We detail the intersection of obesity and breast cancer, with an emphasis on the shared and unique patterns of immune dysregulation in these disease processes. We have highlighted key areas of breast cancer biology exacerbated by obesity, including incidence, progression, and therapeutic response. We posit that interception of obesity-driven breast cancer will require interventions that limit protumor signaling from obese adipose tissue and that consider genetic, structural, and social determinants of the obesity–breast cancer link. Finally, we detail the evidence for various dietary interventions to offset obesity effects in clinical and preclinical studies of breast cancer. In light of the strong associations between obesity and breast cancer and the rising rates of obesity in many parts of the world, the development of effective, safe, well-tolerated, and equitable interventions to limit the burden of obesity on breast cancer are urgently needed.
Associations of Different Emotion Regulation Strategies with Coping-Efficacy, Rumination and Stress
Authors: Rosenbaum David , Int-Veen Isabell , Rubel Julian , Laicher Hendrik , Kroczek Agnes , Lawyer Glenn , Fallgatter Andreas J. , Ehlis Ann-Christine 
Published: June 2022

Abstract
Background
In order to investigate the relationship between stress-reactive rumination and the implementation of different emotion-regulation strategies (ERS), the pilot study at hand assessed ecological momentary assessment data twice per day from currently depressed patients (n = 21) and healthy controls (n = 23).

Methods
We analyzed differences in the implementation of ERS (body-based, behavioral, cognitive, social and multiple) and the occurrence of stress, rumination and self-efficacy between the groups as well as associations of ERS implementation at a given time-point and later levels of stress and rumination.

Results
Overall, patients reported higher subjective stress levels as well as increased ruminative thinking as a response to life stress and, in addition, a more frequent implementation of ERS. Comparing the implementation of ERS, cognitive ERS were implemented most often in the clinical group in comparison to healthy controls. All ERS were associated with increased self-efficacy at the time-point they were implemented. The implementation of cognitive ERS (e.g., reframing) at a given time-point significantly predicted reduced rumination and stress at later time-points.

Conclusions
Clinical and non-clinical groups seem to differ in their implementation of ERS. While the implementation of all investigated ERS is related to increased coping-efficacy, ERS on a cognitive level seem to be advantageous in reducing stress as well as rumination.
Good Traits, Bad Traits, and ‘Ugly’ Behavior: Relations between the Dark Triad, Honesty-Humility, Other HEXACO Personality Traits, and Externalizing Problems in Adolescents
Authors: Muris Peter , Jeurissen Anne , Rooswinkel Morgan , Meesters Cor 
Published: June 2022

AbstractThe present study investigated the relative contributions of the Dark Triad, honesty-humility, and other HEXACO traits to externalizing problems in young people. One-hundred-and-six adolescents aged between 12 and 18 years completed an online survey containing the Dirty Dozen for Youth as an index of the Dark Triad traits of psychopathy, Machiavellianism, and narcissism, the HEXACO-Middle School Inventory to assess honesty-humility as well as five other basic personality factors, and the Youth Self-Report to measure symptoms of oppositional-defiant disorder (ODD) and conduct disorder (CD). Results first of all showed that the Dark Triad traits were positively correlated with symptoms of ODD and CD, while the HEXACO factor of honesty-humility was negatively correlated with such symptoms. Further, both types of externalizing problems were associated with a unique set of personality correlates. More precisely, ODD symptoms were predicted by higher psychopathy and lower agreeableness and extraversion, while CD symptoms were predicted by higher psychopathy (and to some extent Machiavellianism) and lower honesty-humility, extraversion, and emotionality. It is concluded that the study of the role of temperament and personality in externalizing problems should take a broad perspective that includes malevolent and benevolent traits from various theoretical models.
A Mass-Preserving Two-Step Lagrange–Galerkin Scheme for Convection-Diffusion Problems
Authors: Futai Kouta , Kolbe Niklas , Notsu Hirofumi , Suzuki Tasuku 
Published: June 2022

AbstractA mass-preserving two-step Lagrange–Galerkin scheme of second order in time for convection-diffusion problems is presented, and convergence with optimal error estimates is proved in the framework of $$L^2$$

L
2

-theory. The introduced scheme maintains the advantages of the Lagrange–Galerkin method, i.e., CFL-free robustness for convection-dominated problems and a symmetric and positive coefficient matrix resulting from the discretization. In addition, the scheme conserves the mass on the discrete level if the involved integrals are computed exactly. Unconditional stability and error estimates of second order in time are proved by employing two new key lemmas on the truncation error of the material derivative in conservative form and on a discrete Gronwall inequality for multistep methods. The mass-preserving property is achieved by the Jacobian multiplication technique introduced by Rui and Tabata in 2010, and the accuracy of second order in time is obtained based on the idea of the multistep Galerkin method along characteristics originally introduced by Ewing and Russel in 1981. For the first time step, the mass-preserving scheme of first order in time by Rui and Tabata in 2010 is employed, which is efficient and does not cause any loss of convergence order in the $$\ell ^\infty (L^2)$$

ℓ
∞

(

L
2

)

- and $$\ell ^2(H^1_0)$$

ℓ
2

(

H
0
1

)

-norms. For the time increment $$\Delta t$$

Δ
t

, the mesh size h and a conforming finite element space of polynomial degree $$k \in {\mathbb {N}}$$

k
∈
N

, the convergence order is of $$O(\Delta t^2 + h^k)$$

O
(
Δ

t
2

+

h
k

)

in the $$\ell ^\infty (L^2)\cap \ell ^2(H^1_0)$$

ℓ
∞

(

L
2

)

∩

ℓ
2

(

H
0
1

)

-norm and of $$O(\Delta t^2 + h^{k+1})$$

O
(
Δ

t
2

+

h

k
+
1

)

in the $$\ell ^\infty (L^2)$$

ℓ
∞

(

L
2

)

-norm if the duality argument can be employed. Error estimates of $$O(\Delta t^{3/2}+h^k)$$

O
(
Δ

t

3
/
2

+

h
k

)

in discrete versions of the $$L^\infty (H^1_0)$$

L
∞

(

H
0
1

)

- and $$H^1(L^2)$$

H
1

(

L
2

)

-norm are additionally proved. Numerical results confirm the theoretical convergence orders in one, two and three dimensions.
Synthesis, Characterization, and Potential Evaluation of Modified Cellulose Immobilized with Hydroxyquinoline as a Sorbent for Vanadium Ions
Authors: Mubark Amal E. , Eliwa Ahmed A. , Zaki Salah A. , Mohamed Basma T. 
Published: June 2022

AbstractA considerable increase in the importance of vanadium globally and its common uses in many manufacturable alloys made it a target for much scientific research interested in extraction and recovery. A solid modified cellulose sorbent (GCIHQ) was prepared by simple grafting of cellulose, then immobilized with hydroxyquinoline, and examined as a sorbent for V(V) ions. FT-IR, TGA, BET, and SEM–EDX investigations were used to characterize the GCIHQ. A higher surface area for the synthesized GCIHQ resin has been recorded (65.8 m2/g) more than the used cellulose (21.7m2/g). Several vanadium sorption parameters using the modified GCIHQ from the sulfate medium were optimized namely contact time, pH, initial vanadium ions concentration, sorbent dose, and sorption temperature. The kinetics results revealed that the sorption of vanadium ions upon the synthesized sorbent followed the pseudo-second-order with R2 of > 0.99, which indicated that the sorption mechanism was chemical interaction. The sorption process was studied using Freundlich, Langmuir, Dubinin–Radushkevich, and Temkin isotherm models to describe the adsorbent-adsorbate interaction. The Langmuir model was the most fitting model with the experimental results; the experimental adsorption uptake of 113 mg/g was matched with that of the calculated results. The activation energy (Ea) for adsorption was 12.91 kJ.mol−1, indicating the process is to be chemisorption. Thermodynamic characteristics with ΔH of 13.46 kJ/mol and a ΔS 115.15 J/mol.K revealed the endothermic and spontaneous nature.
Production of Sentential Negation in German and Italian Non-fluent Aphasia
Authors: Fyndanis Valantis , Miceli Gabriele , Capasso Rita , Killmer Helene , Malefaki Sonia , Grohmann Kleanthes K. 
Published: June 2022

AbstractThe ability of persons with non-fluent aphasia (PWAs) to produce sentential negation has been investigated in several languages, but only in small samples. Accounts of (morpho)syntactic impairment in PWAs have emphasized various factors, such as whether the negative marker blocks or interferes with verb movement, the position of the Negation Phrase in the syntactic hierarchy or the interpretability of negation. This study investigates the ability of German- and Italian-speaking PWAs to construct negative sentences, as well as the role of verbal working memory (WM) capacity and education in task performance and production of sentential negation. German and Italian differ in the syntactic properties of the negative markers that are relevant here (nichtandnon, respectively). A sentence anagram task tapping into the construction of negative and affirmative declarative sentences was administered to 9 German- and 7 Italian-speaking PWAs, and to 14 German- and 11 Italian-speaking age- and education-matched healthy volunteers. We fitted generalized linear mixed-effects models to the datasets. There was no significant difference between negative and affirmative sentences in either group of PWAs. There was a main effect of verbal WM capacity on task performance, but no interaction between verbal WM capacity and production of negative vs. affirmative sentences. Education did not affect task performance. The results are discussed in light of different linguistically-informed accounts of (morpho)syntactic impairment in non-fluent aphasia.