bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KESELAMATAN DAN KESEHATAN KERJA DI KAPAL LONG LINE KM. ANNA RIZKY 7 YANG BERBASIS DI CILACAP
Authors: Prasetyono Untung , Sarianto Deni , Nugraha Dandi Rivaldi 
Published: March 2022

Keselamatan dan kesehatan kerja ( K3) di kapal telah menjadi perhatian di antara pemerintah dan pebisnis sejak lama. Faktor K3 terkait erat dengan kinerja anak buah kapal (ABK) dan pada gilirannya pada kinerja perusahaan. Semakin banyak fasilitas ke sel amatan kerja, semakin sedikit kemungkinan kecelakaan kerja. Tujuan dari penelitian ini adalah menganalisis potensi resiko keselamatan kerja ABK dan aspek kelayakan, keselamatan dan kesehatan kerja diatas kapal. Penelitian ini menggunakan pendekatan kualitatif deskriptif, jenis penelitian ini adalah studi kasus. Pengumpulan data dilakukan dengan cara wawancara, observasi dan kuesioner. Data-data yang diperoleh di analisis menggunakan matriks IFAS,EFAS dan SWOT. Perhitungan total antara bobot dan nilai skoring pada tabel IFAS dan EFAS penerapan K3 KM Anna Rizky 7 menunjukkan nilai komponen internal sebesar 3,09, sedangkan nilai eksternal sebesar 2,89. Selisih nilai IFAS maupun EFAS bernilai positif, oleh karena itu penerapan K3 KM Anna Rizky 7 berada pada posisi kuadran 1. Hal tersebut berarti strategi yang digunakan adalah strategi progresif (pertumbuhan) yaitu strategi yang bertujuan untuk meningkatkan penerapan k3 demi mencapai pertumbuhan yang baik. Cara yang digunakan untuk melaksanakan strategi tersebut adalah melakukan pelatihan K3 untuk ABK, memberikan jaminan ketenagakerjaan ABK, melengkapi keselamatan atau memperbaharui alat keselamatan serta memperbaiki kondisi kapal dan melaksanakan prosedur kerja keselamatan dan kesehatan kerja di atas kapal .Kata kunci: ABK, K3, SWOT.
STUDI KASUS PENGGUNAAN ALAT TANGKAP IKAN JUBI OLEH NELAYAN DI SULAWESI UTARA
Authors: ST., M.Si Dr. Asia, , Santoso Heru , Mulalinda Palehel , Tumiwa Johnny , Pontoh Peggy 
Published: March 2022

Alat tangkap jubi merupakan salah satu alat tangkap yang digunakan oleh nelayan desa Kampung Ambon dan desa kulu, namun pada penggunaan alat tangkap tersebut terdapat perbedaan dari segi keamanan nelayan. Di desa kampong Ambong dan desa Budo terdapat korban berupa kelumpuhan bahkan jatuhnya korban jiwa oleh nelayan, sedangkan di desa Kulu tidak terdapat korban kelumpuhan dan kematian, pada penelitian untuk menggali penyebab jatuhnya korban pada Nelayan di desa Kampung Ambong dan desa Budo, sedangkan desa Kulu merupakan desa pembanding di ke dua desa tersebut.metode yang digunakan yaitu metode studi kasus, pengambilan data secara wawancara kepada responden dan key informan di desa kampung Ambong. Desa Budo, dan desa kampung Kulu. Kesimpulan pada penelitian adalah penggunaan alat tangkap jubi yang menyebabkan kelumpuhan pada nelayan di desa Kampung Ambong dan desa Budo disebabkan penggunaan alat bantu kompresor yang relative lama, menyelaman pada kedalaman di atas 30 meter dengan waktu yang relatif lama, serta tidak menggunakan teknik ke permukaan dengan cara zig-zag untuk menyesuaikan kondisi tubuh dengan perairan. Kata kunci : alat tangkap, jubi, kedalaman, penyelam
Effect of 3,4-diaminopyridine phosphate in symptomatic SOD1-G93A mice
Authors: Beladakere Ramaswamy Swathi , Stanford John A , Iyadurai Stanley , Govindarajan Raghav , Barohn Richard 
Published: March 2022

Objective: To study the effect of 3,4-diaminopyridine phosphate (3,4-DAPP) on body weight, grip strength, neurological score and survival in symptomatic SOD1-G93A mice.

Method: We administered 3,4-diaminopyridine phosphate (3,4-DAPP) at 0, 8, and 16 mg/kg to SOD1-G93A mice 5 days/week beginning at 90 days of age. We measured body weight, grip strength, neurological score and survival in this model of ALS.

Results: 3,4-DAPP had no influence on body weight, grip strength, neurological score or survival in this transgenic mouse model.

Conclusion: Our study showed that 3,4-DAPP administration had no effects on survival, body weight, grip strength and neurological score of mice with SOD1 mutation. Since the results of this study are of limited significance, larger animal studies are required to investigate the utility of 3,4-DAPP.
Prognostic utility of soluble ST2 biomarker in heart failure patients with reduced ejection fraction
Authors: Nimbolkar Janardan , Chogle Shubha , Chandel Rittu , Poojary Aruna , Kar Shubhra 
Published: March 2022

sST2 is a member of interleukin 1 receptor family biomarker and the concentration of its soluble isoform increases with cardiac stress leading to cardiac fibrosis. It has 2 isoforms the ligand forms sST2L and soluble form. In acute or chronic heart failure the soluble form is highly prognostic and predictive of mortality. It’s a prospective study of patients aged 45 to 90 with reduced ejection fraction and cardiomyopathy. Sample collected for day 1,5,30. There outcome assessed at day 30 and mortality on one year follow up. Total 79 patients studied, 57 LVF cases and 22 healthy controls. 50 males, 29 females, Cardiomyopathy 24 cases. Mean sST2 value 137.7829±89 (SD). At 30 days outcome and one year mortality with significant P value 0.000. As the age increases sST2 levels rises. For cardiomyopathy patients sST2 (141±78). At day 5 and 30 patients improved with decrease in levels where worsened patients had persistent high values. Those patient with more than 250 or implausible values had worse outcome or expired. Most important those responded to appropriate treatment values significantly improved. For cardiomyopathy patients values remained high persistently and ultimately required cardiac transplant or definitive line of treatment. sST2 is diagnostic and prognostic marker in patients with HFrEF presenting as acute or chronic heart failure. Significant p values for 30 days outcome and mortality. In cardiomyopathy patients with persistent high levels were bad prognostic indicator and suggests consideration of definitive line of treatment.
Cystatin GFR better marker than creatinine GFR for accurate prediction of renal dysfunction in diabetic patients: A tertiary care centre study
Authors: Nimbolkar Janardan , Chogle Shubha , Bhandarkar Lata , Poojary Aruna , Chandel Ritu 
Published: March 2022

Diabetic and hypertensive patients gradually gets decreased glomerular function. Creatinine starts rising and exhibits decreased kidney function when more than 50% of glomerular function is lost. Cystatin C, a parameter which accesses kidney function accurately predicts GFR. GFR is calculated by measuring Cystatin C and Creatinine. Groups were normal patients, diabetics patients, Comparison of changes of pre and post treatment GFR by Creatinine and Cystatin. Total 57 patient studied 1) Cystatin C GFR is lower than creatinine GFR in 20 normal patients with P value with paired t test is 0.0032 hence prompts early renal evaluation whereas creatinine GFR overestimates renal function. 2) cystatin C GFR in 37 patients with kidney dysfunction and diabetes is less than Creatine GFR with p-value &#60; 0.05 suggests more accurate prediction for renal injury. 3) Cystatin GFR is affected by age and gender 4) Change in Pre and Post treatment of 9 patients with creatinine GFR and cystatin GFR with p-value = 0.47657 &#62; 0.05 but these patients high Creatinine levels on admission which gets normalised with remarkable rise in GFR whereas Cystatin C levels gets marginally decrease suggests renal recovery ongoing. Clearly exhibits Creatinine GFR is overestimates renal function. Patients with normal GFR by Creatinine having raised Cystatin C levels prompts early renal evaluation. Cystatin C is accurately estimating, less affected by variables and predicting severity of renal dysfunction. Thus, Cystatin C GFR better diagnostic and sensitive maker than creatinine GFR for accurate prediction of renal dysfunction in Diabetic patients.
Polityka wielokulturowości a edukacja obywatelska w Anglii – wybrane aspekty socjopedagogiczne
Authors: Hejwosz-Gromkowska Daria 
Published: March 2022

W angielskim dyskursie politycznym wielokrotnie ogłaszano już koniec wielokulturowości jako idei łączącej więzy społeczne. W niniejszym artykule podjęto próbę analizy dyskursu debaty publicznej wokół problematyki wielokulturowości w Anglii oraz implikacji dla edukacji obywatelskiej. W artykule zostały przedstawione – po pierwsze – założenia edukacji obywatelskiej w kontekście budowania spójnego społeczeństwa w ramach kategorii Britishness, co było fundamentem działań laburzystów po 1997 roku. Po drugie ukazana została koncepcja idei Big Society w kontekście wielokulturowości, zaproponowanej przez Torysów po przejęciu władzy w 2010 roku. Ponadto podjęto próbę znalezienia odpowiedzi na pytanie, czy istotnie nastąpił koniec polityki wielokulturowości, czy też przybrała ona inną formę i jakie znaczenie ma ona dla przyszłości edukacji obywatelskiej.
The Role of Some Parameters in Diagnosis in the Absence of PCR in the Children with COVID-19
Authors: SOLMAZ Abdullah , ERCAN Tuğba Meliha Fatma , ERAT Tuğba , SOLMAZ Filiz 
Published: March 2022

Objective: Infectious diseases cause inflammation in the human body and produce numerical and functional changes in peripheral blood cells. Coronavirus disease-19 (COVID-19) is also an infectious disease diagnosed by the Polymerase Chain Reaction (PCR) test. However, PCR testing may not always be available. The aim of this study is to show the effect of numerical and functional changes in blood parameters on the diagnosis of COVID-19 in children.
Method: In this retrospective study, 296 patients and 286 healthy children were included. Nasopharyngeal swabs were collected. The swabs were analyzed by Real-time PCR. Independent-t/Mann-Whitney-U tests were applied; Receiver Operating Characteristic (ROC) curves and logistic regression modelling were evaluated.
Result: Gender and age distributions of the groups were similar (p>0.05). There were significant differences between the two groups in terms of white blood cell (WBC) (p
IDENTIFICAÇÃO DAS DISFUNÇÕES MICCIONAIS APRESENTADA POR PESSOAS COM DIABETES MELLITUS
Authors: Caselato Sheylla Aparecida Ribeiro 
Published: March 2022

O Diabetes Mellitus (DM) é considerado um agravo de saúde que atinge o metabolismo do acometido e que pode ainda a longo prazo acarretar disfunções a sistemas e/ou órgãos, dentre eles, rins, vasos sanguíneos, olhos e nervos. Além disso, podem aparecer ainda quadros de infecção do trato urinário, hipertensão, dentre outras doenças. Este trabalho teve como objetivos: levantar na literatura as principais causas de complicações miccionais nos portadores de diabetes mellitus e abordar e discorrer sobre a incontinência urinária como sendo uma das principais complicações do diabetes mellitus. Os portadores de DM têm maior risco em desenvolver uma ou mais disfunções urinárias, entretanto, o aumento isolado da glicemia no gênero feminino não está diretamente relacionado com a incontinência urinária (IU). A IU é descrita na literatura como qualquer queixa ou relato da liberação do esfíncter urinário com frequência sem que haja a percepção do paciente acometido. A IU é classificada conforme a ocorrência da perda de urinaria em: IU de esforço, IU de urgência e IU mista. Considerado um problema de saúde pública que acomete ambos os gêneros, em um estudo, 27,6% eram mulheres e 10,5% dos homens. É causada por diversos fatores e pode levar ocasionar transtornos de ordem física, psíquica, profissional, social, sexual e até econômica interferindo assim na qualidade dos indivíduos acometidos por ela. A IU tem impacto significativo na vida das pessoas, principalmente nos idosos, pois, nem sempre, é possível identificar a ocorrência da perda involuntária de urina bem como a queixa, percepção devido a vergonha do paciente acometido. Dessa forma, o aumento da vigilância dos profissionais é fundamental associada a orientação do paciente e familiares em identificarem tais situações facilitando a identificação dos profissionais para que as medidas terapêuticas sejam tomadas evitando maiores agravos quando possível. Conclusão: o desenvolvimento de ações educativas, preventivas e/ou de promoção junto aos profissionais, pacientes familiares e cuidadores são essenciais para que os resultados sejam os melhores possíveis.
Genel anestezi altında diz artroplastisi uygulanan hemofili hastalarında kronik ağrı
Authors: ZEYDANOĞLU Ali , ÇAĞIRAN Zeynep , SERTÖZ Nezih , KARAMAN Semra , DERBENT Abdürrahim 
Published: March 2022

Amaç: Tekrarlayan eklem içi kanamalarıyla seyreden hemofilik artropati, erişkin hemofili hastalarında yaşam kalitesini belirleyen en önemli etkenlerken biridir. Bu artropatinin uzun dönemli etkileri sonucu operasyona alınanların, postoperatif dönemde karşılaştığı en önemli problem olan akut ağrı bazı durumlarda kronikleşmekte ve hastalarda uzun süren yakınmalara neden olmaktadır. Bu çalışmada diz artroplastisi uygulanmış hemofili hastalarında kronik ağrı gelişimini incelemeyi amaçladık. Gereç ve Yöntemler: Mart 2015 ile Aralık 2016 tarihleri arasında diz operasyonu geçiren hemofili hastaları retrospektif olarak incelendi. Postoperatif dönemde Ağrı Sorgulama Formu, Kısa Ağrı Envanteri ve Pain Detect Anketi kullanılarak kronik ağrının varlığı ve özellikleri, ağrının günlük yaşama etkisi ve hastaların analjezik kullanımı değerlendirildi.
Bulgular: Çalışmaya dâhil edilen 42 hastada kronik ağrı insidansının %95,2 olduğu saptandı. Kısa Ağrı Envanteri ve Pain Detect Ağrı anketinin sonuçlarına göre maksimum Numerik Rating Skala değerleri nöropatik karakterde ağrısı olanlarda istatiksel olarak daha yüksek bulundu. Nöropatik karakterde ağrısı olanların olmayan gruba kıyasla istatiksel olarak daha genç yaşta olduğu görüldü. Sonuç: Hemofili hastalarında kronik ağrı insidansı oldukça yüksek düzeydedir. Bu hastaların ağrıya neden olabilecek altta yatan patolojileri, kanama riskleri, profilaksi tedavileri, ortopedik problemleri ve kronik ağrı gelişimine katkı sağlayan duygusal durumlarını da dikkate alan güncel ve kapsamlı yeni tanı yöntemleri kullanılmalı, tedavileri multidisipliner yaklaşımla uzmanlaşmış bir ekip tarafından gerçekleştirilmelidir.
EVALUATION OF ABCB1-PROTEIN INHIBITION PROSPECTIVENESS IN HEMATOENCEPHALIC BARRIER AS METHOD FOR INCREASING EFFICIENCY OF PHARMACOTHERAPY IN CEREBRAL ISCHEMIA
Authors: Chernykh I. V. , Shchulkin A. V. , Gatsanoga M. V. , Yakusheva E. N. 
Published: March 2022

The aim of the article is to evaluate the ABCB1 protein inhibition in the blood-brain barrier to increase the effectiveness of neuroprotective therapy for focal and global cerebral ischemia.Materials and methods. The work was performed on 103 male Wistar rats. In the 1st group (n=33), the neuroprotective activity of the ABCB1 protein substrate, nimodipine (0.4 mg/kg), was analyzed in terms of reducing the area of the brain necrosis after a 1-hour occlusion of the middle cerebral artery with a 24-hour reperfusion (focal ischemia). In the 2nd group (n=60), the effectiveness of nimodipine was analyzed by reducing the lethality of rats and the neurological deficit (ND) level against the background of the bilateral occlusion of the common carotid arteries (global ischemia). In both groups, nimodipine was used alone or in the combination with omeprazole, the ABCB1 protein inhibitor (17.6 mg/kg). The drugs were administered intravenously.Results. The nimodipine administration to the 1st group led to the reduction of the necrosis focus by 28% compared with the control series. Omeprazole did not cause a change in the area of the necrosis. The combination of drugs caused a decrease in the area of the necrosis in relation to the control by 29%; there were no differences in comparison with the nimodipine series. Nimodipine reduced the rats’ lethality in the 2nd group against the background of the pathology (a tendency). Omeprazole alone did not change the mortality. The drug combination reduced the mortality compared to the control and nimodipine series. The administration of omeprazole alone did not reduce the neurological deficit score relative to the control. In the nimodipine series, ND was 88% lower than the control, after 24 hours. With the administration of the drugs combination, this indicator decreased in relation to the control by 88%, 80%, 88%, 87% and 86% after 4, 12, 24, 48 and 72 hours, respectively, and in relation to the nimodipine series it decreased by 60% and 67% after 4 and 48 hours.Conclusion. The ABCB1 protein inhibition is promising for increasing the effectiveness of neuroprotective therapy for global ischemia, but not for focal cerebral ischemia.
EFFECTIVENESS AND SAFETY OF FAVIPIRAVIR INFUSION IN PATIENTS HOSPITALIZED WITH COVID-19
Authors: Balykova L. A. , Zaslavskaya K. Ya. , Pavelkina V. F. , Pyataev N. A. , Selezneva N. M. , Kirichenko N. V. , Ivanova A. Yu. , Rodoman G. V. , Kolontarev K. B. , Skrupsky K. S. , Simakina E. N. , Mubarakshina O. A. , Taganov A. V. , Pushkar D. Yu. 
Published: March 2022

Research in the development of new therapeutic agents with a wide spectrum of the antiviral activity and a low ability to develop resistance remains the main dimension in combating the global threat to public health. The need for a parenteral form of favipiravir was dictated by the necessity to increase the efficacy of therapy in COVID-19 inpatients. This dosage form has expanded the possibilities of drug therapy in the inpatients, for whom a therapeutic effect acceleration and a high safety profile of the drugs used are especially important.The aim of the article is the evaluation of the efficacy and safety of a medicinal product containing favipiravir for the parenteral administration against the background of pathogenetic and symptomatic therapy, in comparison with standard therapy in hospitalized COVID-19 patients.Materials and methods. An open, randomized, multicenter comparative study was conducted in 6 research centers in the Russian Federation to evaluate the efficacy and safety of favipiravir, a lyophilisate for the preparation of a concentrate for the infusion solution administrated to the patients hospitalized with COVID-19. Screening procedures and randomization were completed in 217 patients, 209 of which had completed the study in accordance with the protocol.Results. Between the study groups, statistically significant differences have been found out, making it possible to consider the hypothesis of the drug Areplivir (favipiravir) superiority for the parenteral administration over the standard therapy, which included favipiravir (p. o.) and remdesivir. A comparative analysis has shown that a course of therapy with the parenteral favipiravir drug leads to a significant improvement in the condition of patients with COVID-19, significant benefits in terms of the speed and frequency of improvement in the clinical status of patients, as well as a reduction in the hospital stay length. It has been proven that therapy with a drug containing favipiravir for the parenteral administration does not adversely affect the parameters of clinical and biochemical blood tests, urinalysis, coagulograms, vital signs and ECG, which indicates the therapy safety. The study drug is characterized by a high safety profile and tolerability.Conclusion. The versatility and resistance to mutations of RNA-dependent RNA polymerase make it possible to consider it as the main target for combating the most common RNA viruses that cause ARVI, that determines the need further studies of favipiravir to expand the range of its indications.
PHARMACOLOGICAL ACTIVITY OF EXTRACTS FROM PLANTS OF COSMOS BIPINNATUS CAV. SPECIES
Authors: Kulichenko E. O. , Andreeva O. A. , Sergeeva E. O. , Sigareva S. S. , Terekhov A. Yu. , Oganesyan E. T. , Sidorskaya S. Yu. 
Published: March 2022

The aim of the study is to determine antioxidant, anti-inflammatory and hypolipidemic activities of the extracts from Cosmos bipinnatus Cav. three varieties, obtained by the extraction with 70% ethyl alcohol.Materials and methods. The antioxidant effect was studied in vitro using a model of iron-induced lipid peroxidation in the lecithin liposome system. The study of the anti-inflammatory activity was carried out on 30 male rats of the “Wistar” line. Diclofenac was used as a reference drug (p. o., the dose of 13 mg/kg in terms of the weight of an adult). The substances were administered to animals in the form of an aqueous suspension stabilized with Tween-80. To simulate the inflammatory process, a model of “cotton granuloma” was created. A hypolipidemic activity of the extracts was studied on 36 white male rats of the “Wistar” line. To study the hypolipidemic activity of the studied extracts, a tween model was used to create a hyperlipidemic state in rats, the concentrations of total cholesterol and triglycerides was determined in the serum of the experimental animals.Results. The conducted model experiments made it possible to conclude that the alcohol extracts obtained from the dried inflorescences of the “Dazzler”, “Rosea” and “Purity” varieties of Cosmos bipinnatus Cav. have antioxidant, anti-inflammatory and hypolipidemic kinds of activities. It has been established that the extracts from the “Dazzler” and “Rosea” varieties (Cosmos bipinnatus Cav.) contribute to a better reduction in the accumulation of peroxide compounds, compared to the extract obtained from the “Purity” variety. The data analysis on the anti-inflammatory activity shows that all the studied objects significantly (p = 0.05) reduce the stage of exudation compared with the control group animals by 50% (the «Purity» variety), by 52% (the «Rosea» variety) and by 40% (the “Dazzler” variety).An experiment on the study of a hypolipidemic activity in the control group of the animals revealed a significant, in relation to the values of the intact group, increase in the cholesterol level of the blood serum by 78%, and in the level of triglycerides (TGCs) – by 64%.The administration of the extracts obtained from Cosmos bipinnatus Cav. “Purity”, “Rosea”, “Dazzler” varieties to the animals, led to a decrease in cholesterol in blood serum by 44%, 47%, 50%, and triglycerides by 52%, 52% and 57%, respectively. Both indicators reached the normal level and did not differ significantly from the values in healthy (intact) animals.Conclusion. According to the conducted studies, it can be concluded that alcohol extracts obtained from Cоsmos bipinnatus Cav., have pronounced antioxidant, anti-inflammatory and hypolipidemic kinds of effect.