bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningioma typing model construction using radiomics-based multi-parameter magnetic resonance imaging
Authors: Han Tao , Xu Zhendong , Geng Yayuan , Long Changyou , Zhang Bin , Deng Lingna , Lin Xiaoqiang , Jing Mengyuan , Zhou Junlin 
Published: June 2022

Abstract
Purpose: To investigate the value of a cli-radiomics model based on multi-parameter magnetic resonance imaging (MRI) in differentiating fibroblastic meningiomas from non-fibroblastic meningiomas.Methods: Clinical, imaging, and postoperative pathological data of 423 patients (128 fibroblastic meningiomas and 295 non-fibroblastic meningiomas) were randomly categorized into training (n=296) and validation (n=127) groups at a 7:3 ratio. The Selectpercentile and LASSO were used to selected the highly correlated features from 3376 radiomics features. Different classifiers were used to train and verify the model. The receiver operating characteristic (ROC) curves, ACC, SEN, and SPE were drawn to evaluate the performance. The optimal radiomics model was selected, calibration curves and decision curve analysis were used to verify the clinical utility and consistency of the nomogram constructed from the radiomics features and clinical factors.Results: There were thirteen radiomic features selected from T1C and T2WI after dimensionality reduction. The prediction performance of RF radiomics model is slightly lower than that of the cli-radiomics model. The area under the curve (AUC), SEN, SPE, and ACC of the cli-radiomics model training set are 0.836 (95% confidence interval [CI], 0.795-0.878), 0.922, 0.583, and 0.686; the AUC, SEN, SPE, and ACC of the validation set were 0.756 (95% CI, 0.660-0.846), 0.816, 0.596, and 0.661, respectively.Conclusion: The diagnostic efficacy of the cli-radiomics model of fibroblastic meningioma and non-fibroblastic meningioma was better than that of the radiomics prediction model alone, and can be used as a potential tool for clinical surgical planning and evaluation of patient prognosis.
Projecting Podocarpaceae response to climate change: we are not out of the woods yet
Authors: Twala Thando C. , Fisher Jolene T. , Glennon Kelsey L. 
Published: June 2022

Abstract
Under the changing climate, the persistence of Afrotemperate taxa may be threatened as suitable habitat availability decreases. The unique disjunct ranges of podocarps in southern Africa raise questions about the persistence of these species under climate change. Here, we identified likely environmental drivers of these distributions, characterised the current and future (2070) environmental niches, and projected distributions of four podocarp species in South Africa. Species distribution models were conducted using species locality data for A. falcatus, P. latifolius, P. elongatus and P. henkelii and both historical climate data (1970 – 2000) and future climate scenarios (RCP 4.5 and 8.5, 2061 – 2080) to estimate the current and future distributions. We also used this opportunity to identify the most important climatic variables that likely governed each species’ distribution. Using niche overlap estimates, a similarity test, and indices of niche expansion, stability and unfilling, we explored how niches changed under different climate scenarios. The distribution of the study species was governed by max temperature of the warmest month, temperature annual range, mean temperature of the wettest quarter, and precipitation of the wettest, driest, and warmest quarters. The current distribution of A. falcatus was predicted to expand to higher elevations under RCP 4.5 and RCP 8.5. Podocarpus henkelii was predicted to lose most of its suitable habitat under RCP 4.5 and expand under RCP 8.5, however this was the opposite for P. elongatus and P. latifolius. Interestingly, P. elongatus, which had the smallest geographic distribution, showed the most vulnerability to climate change in comparison to the other podocarps. Mapping the distribution of podocarps and understanding the differences in their current and future climate niches provides insight into potential climate drivers of podocarp persistence and the potential for adaptation of these species. Overall, these results suggest that P. elongatus and P. henkelii may expand to novel environmental niches.
Transient downregulation of miR-671-5p promotes IL-10 mRNA increase in porcine moDCs stimulated with the probiotic BB12
Authors: Bravo-Parra Marlene , Barcenas-Preciado Valeria , Resendiz-Sandoval Monica Guadalupe , Hernandez Jesus , Mata-Haro Veronica 
Published: June 2022

Abstract
Background: Previous work showed that the microRNA (miRNA) miR-671-5p was upregulated in monocyte-derived dendritic cells (moDCs) stimulated with Bifidobacterium animalis subsp. lactis BB12 (BB12) with no increase in IL-10 after six hours of stimulation. In this work, we performed an in silico prediction of genes targeted by miR-671-5p and which are the terms and pathways involved with it. Also, miR-671-5p was transiently downregulated to assess its effect on IL-10 regulation.Methods and Results: First, we performed a Gene Ontology enrichment analysis to predict immune response terms and pathways involved with miR-671-5p. Some of the terms and pathways found were related to the immune response promoted by the probiotic, as the terms "negative regulation of the inflammatory response to an antigenic stimulus" and "cancer" were highlighted. Then, to assess the role of miR-671-5p in IL-10 regulation, moDCs were derived from porcine peripheral blood and later transfected with miR-671-5p antisense oligonucleotide (ASO). Flow cytometry was employed to evaluate the transfection efficiency. Then, the moDCs were stimulated with BB12, and the expression of IL-10 was assessed by RT–qPCR and ELISA. An increase in IL-10 transcript in miR-671-5p-ASO-transfected moDCs stimulated with BB12 was observed compared with moDCs stimulated with BB12 but not transfected. These results suggest the participation of miR-671-5p as a negative regulator of IL-10.Conclusion: These findings suggest that miR-671-5p participates in the downregulation of IL-10, as previously predicted in silico by our work group. miR-671-5p could play an essential role in the immunomodulation promoted by the probiotic BB12.
Serum and Saliva Sirtuin 6, Lipoxin A4, Caspase8 Levels in Correlation with Periodontal Status in Severe Periodontitis
Authors: Cekici Ali , Sahinkaya Selin , Donmez M. Fatih , Turkmen Emrah , Balci Nur , Toygar Hilal 
Published: June 2022

Abstract
Objectives: It has been stated that Sirtuin-6 (SIRT6) play a important role in regulation of inflammation, energy metabolism, homeostasis and apoptosis, and SIRT6 may be assosiciated with many diseases. The aim of this study was to evaluate saliva and serum SIRT6, Lipoxin A4 (LXA4) and Caspase-8 (CASP8) levels in correlation with periodontal clinical status in patients with periodontitis and healthy subjects. Materials and Methods: 20 patients with Stage III Grade B periodontitis (P) and 20 periodontally healthy individuals (control;C) were included in this study. Clinical periodontal parameters were measured. Saliva and serum levels of SIRT6, LXA4 and CASP8 were analyzed by enzyme-linked immunosorbent assay.Results: Serum SIRT6 and saliva LXA4 levels were significantly lower in the periodontitis group than in the control group (respectively; p=0.010, p= p:0.001). There was no statistically significant difference between the periodontitis and control groups for saliva SIRT6, serum LXA4, serum and saliva CASP8 levels (p>0.05). Significant negative correlations were found between all periodontal clinical parameters (PI, BOP, PPD, CAL) and saliva LXA4 level (p<0.05), and between PPD, CAL, and serum SIRT6 level (respectively; r=-0.465 and r=-0.473, p<0.05). Conclusions: This study demonstrated that significantly lower levels of serum SIRT6 and saliva LXA4 in periodontitis patients and their correlation with periodontal status. Detection of SIRT6 and saliva LXA4 might have a potential role for predicting periodontal status in the future with more precise sampling protocols and with better specifity in testing methods. Clinical Relevance: Serum SIRT6 and saliva LXA4 might be promising biomarkers for monitoring the susceptibility to periodontitis and predicting periodontal status.
What can scatterplots teach us about doing data science better?
Authors: Goh Wilson Wen Bin , Foo Reuben , Wong Limsoon 
Published: June 2022

Abstract
A scatterplot is often the graph of choice for displaying the relationship between two variables. Scatterplots are useful for exploratory analysis, but can do much more than just identifying correlations. As datasets get larger and more complex, relying solely on “eye power” alone may cause us to miss interesting associations, or worse, make wrong interpretations. We show that by combining scatterplots with statistical and logical reasoning (the sliding window and two-axis median bisection), we may identify interesting associations in a case study of GRE admission vs graduation outcomes, and whether low detectability of proteins in a biological sample are truly associated with low-abundance. Due to subjective visual interpretability, we recommend graphing the data using a multitude of visual variables and graph types before concluding the absence of an association. Finally, even if associations are demonstrable, developing causal models that could explain the observed fuzziness and lack of apparent correlations in the scatterplot are helpful for better decision making and interpretation.
stabiliser: Variable Selection using a Permutation-based Objective Stability Threshold (POST)
Authors: Hyde Robert , O'Grady Luke , Green Martin 
Published: June 2022

Abstract
Identification of variables truly associated with an outcome, whilst minimising false positives,is critical to any data analysis. This is particularly challenging in wider datasets, where the proportionof false positives tends to increase as the number of variables increases. Whilst stability selection hasbeen demonstrated to improve model performance, arbitrary stability thresholds mean performanceimprovements are model and dataset dependent. We propose a novel permutation-based objectivestability threshold (POST) to enhance the stability selection procedure. The performance of POSTis evaluated through simulation analysis, and performance benefits of POST are demonstrated incomparison with conventional approaches. Furthermore, the advantages of statistical triangulation,the use of multiple models simultaneously, alongside POST are highlighted. To facilitate the implementationof these methods, we present the R package stabiliser, which is designed to improve inferentialmodel performance regardless of model type or dataset structure.
A novel fractional-order accumulation GMP(1,1) model and its application
Authors: Yang Honglin , Gao Mingyun , Xiao Qinzi 
Published: June 2022

Abstract
Considering the effective service life characteristics of products in the background of product sales, this study first designs a generalized fractional-order accumulation generation matrix covering the effective accumulation percentage, replaces this matrix with the first-order accumulation generation operation in classical GMP(1,1), and establishes the definition equation of fractional-order accumulation GMP(1,1) [abbreviated as GFAGMP(1,1,D)] model. Second, the study derives the level ratio of the model via two other forms of the model [GFAGMP(1,1,M) and GFAGMP(1,1,H)] using integral and power function transformation, which is combined with the power function transformation and the relationship between the GFAGMP(1,1) model and the generalized the GM(1,1) model. The optimization model of accumulation generation matrix order $r$, effective accumulation percentage index $p$. and power exponent $m$ . is established, and the parameter optimization of the model is completed through particle swarm optimization. Finally, the simulation results of different grey models are compared with the actual sales data of Chinese refrigerators. This comparison demonstrates the feasibility and effectiveness of the GFAGMP(1,1) model in forecasting the home-appliance supply chain demand in China.
Conformations of Model Peptides With 1-Aminocycloalkane-1-Carboxylic Acid Residues
Authors: Rao Shashidhar N. , Ramnarayan K. , Chan Ming Fai , Balaji V.  N. 
Published: June 2022

Abstract:
We present conformational energy calculations on model compounds contammg 1-amino­ cycloalkane carboxylic acid with 5- (Acc5 )and 6- (Acc6) membered rings using molecular mechanics methods. The low energy models adopt conformations characteristic of ex-helix and polyproline-II-type three- and four-fold helices. The energetically most favored models adopt the α /3 10-helical conformation of either handedness in these compounds. The salient features of our investigations are qualitatively consistent with the crystal structures of peptide analogs containing Acc5 and Acc6 and previously reported solution phase and conformational studies on peptides containing Acc5 .Our results have implications for the design of α /310-helical peptidomimetics.
Sequence Dependent Conformational Motion of a Peptide in the HLA-A2 Binding Groove
Authors: Meng Wilson S. , Gallaher Timothy K. , Grafenstein Hermann von , Haworth Ian S. 
Published: June 2022

Abstract:
Using a simulated annealing/molecular dynamics approach. we were able to reproduce the x-ray
crystallographic conformation of the peptide GILGFVFTL when bound to the class I MHC molecule HLA-A2, starting from the backbone conformation of a second peptide TLTSCNTSV obtained from crystallographic data. Observations made during this work led us to a hypothesis of the possible hierarchy of non-covalent interactions that cause GILGFVFTL to adopt its conformation in the HLA-A2 peptide binding groove.
An Overview of the Neuropharmacological Potential of Thymoquinone and its
Targeted Delivery Prospects for CNS Disorder
Authors: Verma Rishabh , Sartaj Ali , Qizilbash Farheen Fatima , Ghoneim Mohammed M. , Alshehri Sultan , Imam Syed Sarim , Kala Chandra , Alam Md. Shamsher , Gilani Sadaf Jamal , Taleuzzaman Mohamad 
Published: June 2022

Abstract:
At present, people and patients worldwide are relying on the medicinal plant as a therapeutic agent over
pharmaceuticals because the medicinal plant is considered safer, especially for chronic disorders. Several medicinal
plants and their components are being researched and explored for their possible therapeutic contribution to CNS
disorders. Thymoquinone (TQ) is one such molecule. Thymoquinone, one of the constituents of Plant Nigella Sativa,
is effective against several neurodegenerative diseases like, Alzheimer's, Depression, Encephalomyelitis, Epilepsy,
Ischemia, Parkinson's, and Traumatic. This review article presents the neuropharmacological potential of TQ's, their
challenges, and delivery prospects, explicitly focusing on neurological disorders along with their chemistry, pharmacokinetics,
and toxicity. Since TQ has some pharmacokinetic challenges, scientists have focused on novel formulations
and delivery systems to enhance bioavailability and ultimately increase its therapeutic value. In the present
work, the role of nanotechnology in neurodegenerative disease and how it improves the bioavailability and delivery
of a drug to the site of action has been discussed. There are a few limitations to developing novel drug formulations,
including solubility, pH, and compatibility of nanomaterials. Since here we are targeting CNS disorders, the bloodbrain
barrier (BBB) becomes an additional challenge.
Hence, the review summarized the novel aspects of delivery and biocompatible nanoparticles-based approaches for
targeted drug delivery into CNS, enhancing TQ bioavailability and its neurotherapeutic effects.
Short-term Neuropsychiatric and Body Weight Changes in Patients
Switching From EVG/Cobi/FTC/TAF to BIC/FTC/TAF (PreEC/RIS69)
Authors: Tiraboschi Juan , Prieto Paula , Saumoy Maria , Silva Ana , Imaz Arkaitz , Scevola Sofía , Fernandez Guillem , Navarro Antonio , Piatti Camila , Podzamczer Daniel 
Published: June 2022

Background:
We report NP, clinical and laboratory changes in patients switching from
EVG/Cobi/FTC/TAF to BIC/FTC/TAF in clinical practice.

Methods:
A group of subjects switching from EVG/Cobi/FTC/TAF to BIC/F/TAF was prospectively
followed. A validated sleep quality questionnaire (Pittsburgh Sleep Quality Index), as well as the
Hospital Anxiety and Depression Scale (HADS), were administered after 4 weeks from the treatment
switch. Adverse events, side effects and discontinuation were recorded at weeks 4 and 24. Pretreatment
switch and week 24 body weight and laboratory data were compared.

Results:
A total of 96 virologically suppressed patients (86% male) were included. All patients received
EVG/Cobi/FTC/TAF at least 1 year before the treatment switch. Median (IQR) nadir CD4
was 367 (263). The most common comorbidities were dyslipidemia, HTA and diabetes, 26%, 14%
and 7%, respectively. Depression was reported by 8%. Five patients discontinued BIC/FTC/TAF
before week 4 due to intolerance (2 insomnia, 1 headache and 2 GI symptoms). No changes in sleep
quality, anxiety and depression outcomes were observed at week 4 (p = 0.1, p = 0.1 and p = 0.3, respectively).
After 6 months, the median body weight change was statistically significant (0.6 kg,
p = 0.003). All patients maintained HIV suppression.

Conclusions:
Except in a few cases, sleep quality, anxiety and depression symptoms remain stable in
HIV virologically suppressed patients on EVG/Cobi/FTC/TAF who switch to BIC/F/TAF. NPAEs
are mild and tend to occur in those with previous neuropsychiatric symptoms. Weight gain tends to
be small but statistically significant. Long-term follow-up in “real-life” cohorts would be needed to
confirm these findings.
Gender Preference in Gynecology and Obstetrics (GPGO) Scale
Authors: Hage Said El , Daaboul Michael , Sayde Georgio , Ismail Omar , Jamaleddine Youssef , Hallit Souheil , Salameh Pascale 
Published: June 2022

Background:
Patients' preferences towards their physicians constitute a crucial part of providing patient-centered care. Gender preference of patients towards gynecologists/obstetricians is controversial.

Objective:
Authors aimed to develop and validate a scale that specifically assesses gender preferences of patients towards physicians in the obstetrics and gynecology field.

Materials and Methods:
Epidemiological cross-sectional study in Lebanon conducted on 1192 participants. Questionnaire used consist of two parts: the first part sociodemographic questions and obstetrics and gynecology specialists overview and the second part was divided into males' and females' perceptions towards gynecologists. The new developed GPGO scale, consisting of 13 items, was only intended for females. Statistical analysis was performed to test the internal reliability, convergent validity, and construct validity.
Overall, there were 1192 responses, 890 females and 302 males. In this study, we only included females’ responses.

Results:
Tests of assumptions of sample adequacy showed communalities higher than 0.3. Factor analysis of the 13 items in the GPGO scale revealed two main components. Items adequately loaded into its component. The scale’s Cronbach alpha, indicating internal reliability, revealed good reliability (0.861). Component 1 had acceptable internal reliability (Cronbach alpha= 0.745). Component 2 had high internal reliability (Cronbach alpha= 0.846). Pearson correlation coefficients were 0.877 (p<0.0001) and 0.898 (p<0.0001), respectively. Therefore, the scale shows adequate convergent validity.

Conclusion:
The resulting GPGO scale, that assesses the preference of patients towards gynecologists and obstetricians, is validated for use in females aged 18 years old and higher. The scale can be used in future studies for comparison or prospective follow-up.
Imputability of Azathioprine in the Occurrence of Chronic Myeloid Leukemia
in Crohn's Disease: An Exceptional Case Report
Authors: Zaimi Yosra , Bouksir Chayma , Ayadi Shema , Ayari Myriam , Ksontini Feryal Letaief 
Published: June 2022

Background:
Background: Patients with Cohn’s disease (CD) treated with thiopurines are at an increased risk of developing cancer. Leukemias are less frequent than other hematopoietic tumors and development of Chronic myeloid leukemia (CML) after immunosuppression has not been proven.

Case Report:
We describe the case of a 61-year-old female who developed a CML after 8 years of treatment with azathioprine (AZA) for ileal Crohn’s disease associated to a duodenal localization. We reviewed the current evidence on the interactions between CD, CML and AZA as well as the potential underlying mechanisms of leukemia in AZA-treated patients.

Conclusion:
We concluded that the pathogenesis of CML is multifactorial in CD. The nature of the association between AZA and CML in CD patients warrants further investigation.
Pleural Effusion Induced by Systemic Consumption of Topical Minoxidil:
A Rare Case Report
Authors: Tanguturi Yella Sri Hari , Kumar Kistigari Satyanarayana Pramod , Tanguturi Yella Sree Sudha , Kuotsu Ruuzeno , Krishna Sasanka Kota Sesha Brahma Sree , Thangaraju Pugazhenthan 
Published: June 2022

Introduction:
Pleural effusions can be caused by several conditions such as cancer, connective tissue disease, and infection. They are occasionally caused due to the drug as an adverse reaction. Most commonly systemic minoxidil use can cause pleural effusions in patients with chronic kidney disease.

Case presentation:
We present a case of a patient without chronic kidney disease who developed pleural effusion as a result of unintentional use of topical minoxidil orally. The patient's oxygen saturation was 90% on room air, there was dullness to percussion and asymmetrical chest expansion with diminished air entry on both sides. In chest x-ray there was bilateral pleural opacities. In ultrasonography of the chest, it was showed minimal pleural effusions. The patient was managed with diuretics and airway management which resolved completely.

Conclusion:
Minoxidil is a commonly used drug by many people for the treatment of hair fall with or without doctor advice. We would like to stress that even though rare, physicians/pulmonologists should be aware of its rare side effects of topical minoxidil, and it should be kept in mind as a differential diagnosis for pleural effusion.
Cancer Cell De-Differentiation: Plasticity-Driven Stratagem For Tumor
Metastasis and Recurrence
Authors: EL Marsafy Sanaa , Larghero Jérôme 
Published: June 2022

Abstract:
Tumor recurrence is a colossal challenge in clinical oncology. This multifactorial problem is
attributed to the emergence of additional genetic mutations and the presence of dormant cancer cells.
However, the plasticity of non-stem cancer cells and the acquisition of cancer stem cell (CSC) functionality
is another contributing factor to tumor recurrence. Herein, I focus attention on the mechanisms that
fuel cancer cell de-differentiation and the interplay between intra-cellular regulators and tumor microenvironment
(TME) landscape that promotes cancer cell stemness. Our understanding of the mechanisms
underlying tumor cell de-differentiation is crucial for developing innovative therapeutic strategies that
prevent cancer from ever recurring.