bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Protective Role of Physical Fitness on Cardiometabolic Risk During Pregnancy: The GESTAtion and FITness Project
Authors: Acosta-Manzano Pedro , Acosta Francisco M. , Flor-Alemany Marta , Gavilán-Carrera Blanca , Delgado-Fernández Manuel , Baena-García Laura , Segura-Jiménez Víctor , Aparicio Virginia A. 
Published: March 2022

Physical fitness (PF) is a cornerstone of metabolic health. However, its role in maternal–fetal metabolism during pregnancy is poorly understood. The present work investigates: (i) the association of PF with maternal and fetal cardiometabolic markers, and with clustered cardiometabolic risk during pregnancy, and (ii) whether being fit counteracts cardiometabolic abnormalities associated with overweight/obesity. Several PF components (flexibility, lower and upper body strength, and cardiorespiratory fitness [CRF]) were objectively assessed in 151 pregnant women at gestational weeks 16 and 33, and an overall PF cluster score calculated. At the same times, maternal glycemic and lipid markers, cortisol, and C-reactive protein were assessed with standard biochemical methods, along with blood pressure and a proxy for insulin resistance, and a cardiometabolic risk cluster score determined. These analytes were also measured in maternal and umbilical cord arterial and venous blood collected at delivery. PF was found to be associated with several maternal and a small number of fetal cardiometabolic markers (p < .05). Lower and upper body muscle strength, CRF, overall PF (week 16), and CRF changes (weeks 16–33) were inversely associated with clustered cardiometabolic risk (p < .05). Normal weight fit women had lower values for insulin level, insulin resistance, triglycerides, low-density lipoprotein cholesterol, C-reactive protein, and diastolic blood pressure than did overweight/obese unfit women at week 16 (p < .05). In conclusion, greater PF, especially muscle strength and CRF in early–middle pregnancy, appears to be associated with a better metabolic phenotype, and may protect against maternal cardiometabolic risk. “Keep yourself fit and normal weight before and during early pregnancy” should be a key public health message.
The contribution of Walter Alvarez to the investigation of the Capitoline Hill in Rome
Authors: Ammerman Albert J. 
Published: March 2022

ABSTRACT
The chapter consists of five sections. The first one provides an introduction to the collaboration between Walter Alvarez and the author in the interdisciplinary study of the Capitoline Hill in the early 1990s. The second section turns to how we first met in Rome in 1970 and our parallel pathways over the next two decades that saw each of us take the lead in developing a big new idea based on innovative interdisciplinary research. The third section gives the earth scientist essential background on the study of early Rome: such things as the seven kings of Rome, the original topography of the early city, and the syndrome of the eternal Rome. The fourth section develops an overview on the work that we conducted on the Capitoline Hill and the new results obtained. In the fifth section, we step back and consider the contribution of Walter Alvarez to our subsequent research and publications on early Rome and the emergence of the field of geoarchaeology in the study of ancient Rome.
Dinosaurs could not help it, can we? Big history and planetary health
Authors: García-Moreno* Olga , Oranje Maarten P. 
Published: March 2022

ABSTRACT
One of the most recent intellectual enterprises of the scientist honored in this book, Walter Alvarez, is the dive into big history. Alvarez’s research and worldview contributed directly to the foundations of this transdisciplinary field. In this paper, the relevance of big history to the emergent idea of planetary health is demonstrated. Since big history studies both natural and human-made systems over long periods of time, it is uniquely positioned to help address the three categories of challenges identified within planetary health: imagination, knowledge, and governance. Most extensively, this paper focuses on governance challenges. A case study on the Ethiopian health system illustrates that governance frameworks can be reimagined in such a way that incentives and efforts of actors within the system are aligned, producing better human health outcomes. For Homo sapiens to have a better chance of survival than dinosaurs did 66 million years ago, these lessons will need to be applied more broadly in the planetary health domain.
The contrasting geologic record of inferred “hot” intraoceanic and “cold” continental margin subduction initiation
Authors: Wakabayashi* John , Shimabukuro* David H. 
Published: March 2022

ABSTRACT
Two contrasting field relationships may reflect different tectonic settings of subduction initiation preserved in orogenic belts. “Hot” subduction initiation assemblages include a large ophiolite unit (up to kms thick, extending tens to hundreds of km along strike) with supra subduction zone (SSZ) geochemical affinity that structurally overlies a thin (&lt;500 m thick) sheet of high-pressure (HP), high-temperature (HT), primarily metamafic rocks called a metamorphic sole. The ophiolite generally lacks burial metamorphism and includes variably serpentinized peridotite at its base. The sole structurally overlies subduction complex rocks made up of oceanic materials (igneous part of oceanic crust and overlying pelagic sedimentary rocks, and clastic sedimentary rocks of trench fill affinity) and/or passive margin assemblages; some of the subduction complex may be metamorphosed under HP-low temperature (LT) conditions (such as blueschist facies). The field relationships suggest initiation of subduction within young (&lt;15 My) and “hot” oceanic lithosphere and that the sole represents the first slice(s) of material transferred from the subducting to upper plate. Examples include the Neotethyan and northern Appalachian ophiolites and units beneath them, and the Coast Range ophiolite and subjacent Franciscan subduction complex of California.
“Cold” subduction initiation assemblages lack SSZ ophiolite and island arc components and a metamorphic sole. Instead, the upper plate above the subduction complex is made up of continental lithosphere that last experienced significant heating during a passive-margin forming rift event. The protoliths of the rocks subducted were &gt;70 My in age at the time of subduction initiation. The HP-LT subduction complex is composed of slices of continental crust and oceanic crust representing parts of a hyperextended continental margin. These field relationships suggest initiation of subduction along a continental margin within old (“cold”) hyperextended continental lithosphere. Examples include the Apennine subduction zone, exposed in Calabria, Italy, and the Alpine orogenic belt, both remnants of the Alpine Tethys.
The Jurassic structural high of Sasso di Pale (Umbria-Marche Basin, Italy): How a small Apennine structure recorded Early to Middle Jurassic global perturbations
Authors: Baldanza* Angela , Bizzarri* Roberto , Bartolini* Annachiara , Bertinelli* Angela , Colacicchi* Roberto 
Published: March 2022

ABSTRACT
The reduced Jurassic sedimentary sequences deposited on a structural high in the Umbria-Marche Apennines, as well their relationships with adjacent expanded basinal sequences, have been reconstructed through detailed, interdisciplinary study of the Sasso di Pale and Monte Serrone areas near Foligno, Italy. The physiographic features of the basin originated in the Early Jurassic (latest early Pliensbachian), when extensional tectonic activity broke up a shallow water platform where the Calcare Massiccio had been deposited, and the area evolved from an edge-stepped structural high to a distally steepened ramp. The biostratigraphic framework of this paper is mainly based on calcareous nannofossils, which are a useful tool for dating condensed Jurassic successions. Although the sections studied have limited thickness and much lateral facies variation, the sedimentary evolution can be traced and interpreted within a wider Jurassic environmental perspective. In the upper Pliensbachian–lower Bajocian interval, local sea-level variations are compatible with the global sea-level curve. Furthermore, some of the characteristic events—such as the Pliensbachian–Toarcian crisis, the Early Toarcian Jenkyns Event, and the Middle Jurassic carbonate crisis—can be recognized. The present study shows how the reconstruction of local paleogeography can fit into a more general framework and how regional and global signals can be recognized even in a small structural high such as the one we have investigated.
Impact-crater ages and micrometeorite paleofluxes compared: Evidence for the importance of ordinary chondrites in the flux of meteorites and asteroids to Earth over the past 500 million years
Authors: Schmitz* Birger , Schmieder Martin , Liao Shiyong , Martin Ellinor , Terfelt Fredrik 
Published: March 2022

ABSTRACTAlthough the ~200 impact craters known on Earth represent only a small fraction of the craters originally formed, the available data suggest an excess of craters by one order of magnitude, in number, in the interval ca. 470–440 Ma during the Ordovician. Most of these “excess” craters may be related to the breakup of the L-chondrite parent body (LCPB) in the asteroid belt at 465.8 ± 0.3 Ma. This is the only obvious peak in the crater-age record that can currently be attributed to an asteroid breakup and shower event. Spatial crater densities in regions with high potential for crater preservation (e.g., Canada and Scandinavia) support a one order-of-magnitude increase in the flux of large (&gt;0.1 km) impactors following the LCPB breakup. A similar pattern as seen in the cratering record is emerging in studies of the flux of micrometeoritic chrome spinel through the Phanerozoic, with so far only one major spike in the flux, and associated with the LCPB breakup. Similarly, the record of K-Ar and (U-Th)/He gas retention ages of recently fallen meteorites only locates one major breakup, the LCPB event, during the Phanerozoic. On the other hand, astronomical backtracking studies of the orbits of asteroid family members indicate ~70 major family-forming breakups within the past ~540 m.y., which apparently have not left any clear imprint in Earth’s geological record. The chrome-spinel grains recovered in our studies dominantly represent large micrometeorites (&gt;300 µm) and as such are also representative of the flux of larger meteorites to Earth. An observed, nearly constant flux of ordinary chondritic chrome-spinel grains throughout the Phanerozoic, except after the LCPB event, indicates that the present situation—with a clear dominance of ordinary chondritic matter in the large (&gt;500 µm) micrometeorite and macroscopic meteorite fractions—has prevailed at least for the last 500 m.y. This is also supported by generally high ratios in our samples of chrome-spinel grains from ordinary chondrites compared to other types of spinel-bearing meteorites. The chrome-spinel data together with the abundance of fossil meteorites (1–21 cm in diameter) on the Ordovician seafloor also sets an upper limit at one order of magnitude on the increase in flux of large (&gt;0.1-km-diameter) L-chondritic projectiles to Earth following the LCPB. Such an increase would not stand out in the global cratering record if ordinary chondritic impactors had only represented a small fraction of all Phanerozoic impactors. We argue that the origin of impactors delivered to Earth during the past 500 m.y. has mirrored the flux of large micrometeorites and meteorites, with ordinary chondrites being an important or, most likely, the dominant (in numbers) component throughout.
Planetary defense: The communication challenge—Lessons from the COVID-19 pandemic
Authors: Nagel Lea K. , Albrecht Rudolf , Koeberl* Christian 
Published: March 2022

ABSTRACT
As impact events are known to have had severe effects on the geological and biological evolution of the Earth, the need to detect potentially hazardous objects that might collide with the Earth, and to possibly protect our planet from asteroid impacts, has been recognized in recent years. Planetary defense covers human activities to address potential impacts of Near-Earth Objects on Earth. Once the immediate threat of such an impact is obvious, this fact, along with the intended countermeasures, will have to be communicated to the public. There is a parallel to the recent coronavirus (COVID-19) situation: an imminent threat and the required response are being communicated. Reactions between acceptance and cooperation all the way to denial, conspiracy theories, fake news, and active opposition can be observed. It is evident that these factors will have to be considered in the strategy for communicating the asteroid threat.
The Bottaccione Gorge and Gubbio: Hypotheses for a history of the city
Authors: Sannipoli* Ettore A. , Cencetti* Corrado 
Published: March 2022

ABSTRACT
The Bottaccione Gorge at Gubbio, in central Italy, has been an important source of information about Cretaceous and Paleogene Earth history. At the much younger end of the historical continuum, it is also important for understanding the early history of Gubbio itself, for which the only written, although somewhat ambiguous, evidence comes from the Tavole eugubine, the unique bronze tablets which are a kind of Rosetta Stone for the Umbrian language. The role of the Bottaccione Gorge is debated in the history of Gubbio. The road through the gorge, crossing the Monti di Gubbio, is an important element for explaining the location of the city. One of the first settlements (late Bronze Age) is recognized from archaeological evidence at the top of a morphological fault scarp on the slope of Monte Ingino. In the Iron Age, the city described in the Tavole eugubine developed, in which Okri (fortress), Tota (city), and three sacred gates are mentioned. The locations of Okri, Tota, and the gates are still under study. According to the most likely hypothesis, Tota would have developed in the plain, on the right bank of the Torrente Camignano, while the initial settlement would have been transformed into Okri, to which the sacred gates would belong. Another gate may have been placed at the entrance to the Bottaccione Gorge. When the Eugubini (the people of Gubbio) built the new, post-Roman Gubbio in the twelfth century, they still identified, as the most suitable place for a fortified city, the location above the scarp on the slope of Monte Ingino, and they built two new gates at its lateral ends. The city was likely equipped with a third gate that faced the Bottaccione Gorge. In the thirteenth century, the Bottaccione Aqueduct was built to bring water to the highest point of Gubbio. Thus, two waterways—one natural (Torrente Camignano) and the other artificial—still branch off from Bottaccione to reach Gubbio at two different points that determine the lowest and highest levels of the city.
Latest Silurian syntectonic sedimentation and magmatism and Early Devonian orogenic gold mineralization, central Newfoundland Appalachians, Canada: Setting, structure, lithogeochemistry, and high-precision U-Pb geochronology
Authors: Honsberger I.W. , Bleeker W. , Kamo S.L. , Sandeman H.A.I. , Evans D.T.W. , Rogers N. , van Staal C.R. , Dunning G.R. 
Published: March 2022

Abstract
The eastern Dunnage Zone of the central Newfoundland Appalachians hosts Paleozoic orogenic gold mineralization along a northeast-trending, crustal-scale fault corridor that extends for more than 200 km. This orogenic gold system is characterized by polyphase, structurally controlled, quartz vein systems that cut Neoproterozoic granitoid rocks and unconformably overlying syntectonic, polymict conglomerate and associated transitional to calc-alkaline bimodal igneous rocks.
High-precision chemical abrasion–isotope dilution–thermal ionization mass spectrometry (CA-ID-TIMS) U-Pb geochronology confirms a widespread, latest Silurian magmatic pulse (422–420 Ma) that is attributed to a transient phase of lithospheric extension resulting from asthenospheric and crustal melting related to slab break-off. Syntectonic conglomerate was deposited as a basal unit during extension-related uplift and erosion that lasted until ca. 418 Ma in north-central Newfoundland. Orogenic gold mineralization associated with syntectonic sedimentation and magmatism is hosted within third-order shear vein systems that form offshoots within a triangle zone–like structural corridor between southeast- and northwest-dipping, second-order fault splays and shear zones. The southeast-dipping fault system formed during northwest migration of the Acadian thrust front, whereas the northwest-dipping faults and shear zones are Salinic structures that were reactivated in the Early Devonian.
Primary hydrothermal rutile in the orogenic gold-mineralized quartz veins produced ages of ca. 410 Ma. These ages are consistent with quartz vein emplacement and orogenic gold mineralization as a result of hydrothermal fluid-pressure cycling related to far-field compression and thermal perturbations during the Early Devonian Acadian orogenic cycle. The setting and process evolution of the central Newfoundland gold district are remarkably similar to that of world-class orogenic gold systems of the Canadian Shield.
Stated preferences for family doctor contract services: a survey of the rural elderly in Anhui Province, China
Authors: Wang Cuilian , Gu Yuanyuan , Zhao Linhai , Zhang Youran , Zhou Rui , Gu Megan , Wang Lidan 
Published: March 2022

ObjectiveA number of factors contribute to the utilisation of family doctor contract services (FDCS) in China. This study aims to measure the preferences of the elderly for the FDCS and identify the key factors (and their relative importance) that may guide policymakers in more accurately providing the FDCS.Participants and methodsA discrete choice experiment was performed to elicit the preferences for FDCS among the rural elderly in China. Attributes and levels were established based on qualitative methods. Four attributes were included: service type, service package, physician’s reputation and annual contract costs. A D-efficient design was used to create a set of profiles that represented FDCS. The survey was conducted face to face using a sample of participants aged 60 and above in rural areas of Anhui Province. The data were analysed using a latent class logit (LCL) model.ResultsA total of 545 valid questionnaires were included in the analysis. The average age of the participants was 69.44 (SD 5.80). Two latent classes were identified with the LCL model. All four attributes proved statistically significant at the level of both the population mean and the two classes. The rural elderly showed a preference for FDCS with a relatively good reputation, lower annual contract costs, the basic service with the add-on of chronic disease service and home visit. Age, gender, education, self-reported health status and the number of chronic diseases were found to be associated with latent class membership.ConclusionIn this study, the physician’s reputation had the largest impact on the rural elderly’s choice of FDCS. Policy recommendations included the need to strengthen family doctor team training, devote greater attention to improving the family doctor’s medical skills and service approaches, and increased FDCS efficiency for the care of the rural elderly.
Health status and healthcare services utilisation among unaccompanied asylum-seeking minors settled in Switzerland: a protocol for a retrospective cohort study from a hospital-based youth outpatient clinic
Authors: Patseadou Magdalini , Chamay Weber Catherine , Haller Dagmar M 
Published: March 2022

IntroductionUnaccompanied asylum-seeking minors (UASMs) represent a population group with complex healthcare needs. Initial and ongoing healthcare is challenging for host countries but considered essential. This publication describes the protocol concerning a large cohort of UASMs settled in Switzerland in 2015–2016. Our aim is to assess their health status and examine their trajectories of healthcare services utilisation during the 3-year period after their initial health control.Methods and analysisWe will retrospectively analyse data of all newly arrived UASMs aged 12–18 years who benefited from a first health assessment at the Youth Clinic of Geneva University Hospitals between 1 January 2015 and 31 December 2016. Source of data will be electronic medical records. Main outcomes include the determination of their health status (acute and chronic conditions) and the utilisation of different care sectors (ambulatory primary care and subspecialty clinics, emergency room and inpatient wards). A secondary outcome will be the identification of patients at risk for high use of services as well as those with limited access to care. We will extract the following data: demographic characteristics (age, gender and country of origin), social determinants (place of residence, the presence of family in Geneva, school performance and asylum status), clinical information (reason for attending service, anthropometric measurements and medical diagnosis at discharge) and laboratory parameters (complete blood count, ferritin level, 25-hydroxyvitamin D level, hepatitis B antigen and antibodies, tetanus antibodies, QuantiFERON and stool and serology tests for intestinal parasites). We will collect data from first health assessment and during a follow-up period of 3 years for each patient.Ethics and disseminationIn accordance with the Swiss clinical research law, this protocol has been approved by the local ethics committee (project ID: 2021–01260). Our findings will provide important information for the development of quality healthcare services focusing to UASMs. We intend to disseminate our results through publication in peer-reviewed journals.