bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS LINGKUNGAN KERJA PENGRAJIN BATIK TULIS PADA PEKERJA TETAP DAN PEKERJA BORONG LEPAS DI DESA WISATA JARUM
Authors: Mahachandra Manik , Rumita Rani , Aisyah Wahyu Nur 
Published: November 2022

Desa Wisata Jarum merupakan kawasan industri batik yang dibuka untuk destinasi wisata. Pengrajin batik tulis terbagi menjadi dua kelompok yaitu pekerja tetap dan pekerja borong lepas. Kedua kelompok tersebut mempunyai kondisi kerja yang berbeda. Perbedaan kondisi kerja diindikasi dapat mengakibatkan perbedaan lingkungan kerja. Lingkungan kerja yang nyaman dapat meningkatkan kinerja pekerja. Sebagai upaya untuk menentukan lingkungan kerja yang lebih nyaman, dibutuhkan analisis perbandingan. Mann Whitney U Test digunakan untuk membandingkan nilai rata-rata dua kelompok independen sampel. Uji ini juga digunakan untuk mengetahui apakah usia dan lama bekerja berpengaruh terhadap respon responden. Penilaian lingkungan kerja terdiri dari tujuh dimensi yaitu temperatur, pencahayaan, kebisingan, tata ruang, pengawasan, suasana kerja, dan struktur tugas. Hasil penelitian ini menemukan bahwa 71,43% lingkungan kerja antara kedua kelompok pengrajin batik tulis signifikan berbeda. Pekerja tetap mempunyai tiga dimensi yang lebih baik, sedangkan pekerja borong lepas mempunyai dua dimensi yang lebih baik. Dari hasil analisis, pekerja tetap sebaiknya mengevaluasi dimensi kebisingan dan suasana kerja, sedangkan pekerja borong lepas sebaiknya mengevaluasi dimensi pencahayaan, pengawasan, dan struktur tugas. Dapat disimpulkan bahwa pekerja tetap mempunyai lingkungan kerja yang lebih baik. AbstractJarum Tourism Village is a batik industrial area open to tourist destinations. Batik Tulis's craftswomen are divided into two groups: permanent workers and freelance workers. Both groups have different working conditions. Differences in work conditions are indicated that can affect differences in the work environment. Moreover, a comfortable work environment can increase worker performance. Therefore, a comparative study was needed to determine a comfortable work environment. Mann-Whitney U test compared the mean values between two independent sample groups. The test was also applied to determine whether the age and length of work affected the participant's response. The work environment assessment consisted of seven dimensions, i.e., temperature, lighting, noise, layout, supervision, work atmosphere, and task structure. This study found that 71.43% of the work environment between two groups of batik craftswomen differed significantly. Permanent workers encountered three better dimensions, while freelance workers had two better dimensions. From the analysis, permanent workers should improve the noise and work atmosphere conditions, while freelance workers should enhance the lighting condition, supervision, and task structure dimensions. In summary, permanent workers experienced a better work environment.Keywords: batik craftswomen; work environment; comparison test
Model predictive control for retinal laser treatment at 1 kHz
Authors: Schaller Manuel , Kleyman Viktoria , Mordmüller Mario , Schmidt Christian , Wilson Mitsuru , Brinkmann Ralf , Müller Matthias A. , Worthmann Karl 
Published: November 2022

Abstract
Laser photocoagulation is a technique applied in the treatment of retinal disease, which is often done manually or using simple control schemes. We pursue an optimization-based approach, namely Model Predictive Control (MPC), to enforce bounds on the peak temperature and, thus, to ensure safety during the medical treatment procedure – despite the spot-dependent absorption of the tissue. The desired laser repetition rate of 1 kHz is renders the requirements on the computation time of the MPC feedback a major challenge. We present a tailored MPC scheme using parametric model reduction, an extended Kalman filter for the parameter and state estimation, and suitably tuned stage costs and verify its applicability both in simulation and experiments with porcine eyes. Moreover, we give some insight on the implementation specifically tailored for fast numerical computations.
Cardiac troponins – a paradigm for diagnostic biomarker identification and development
Authors: Lackner Karl J. 
Published: November 2022

Abstract
The introduction of cardiac troponins into clinical diagnostics has not only improved diagnostic pathways for myocardial infarction but also profoundly influenced the definition of myocardial infarction. The term troponin appeared in the literature almost 60 years ago, i.e. shortly after this journal was founded. The development of cardiac troponins from proteins involved in muscle contraction, which were in the focus of few specialized research groups from physiology and biochemistry, to one of the most frequently measured protein biomarkers in medicine is a paradigmatic success story which is also reflected in almost 300 publications on the topic in this journal. From the viewpoint of biomarker development the critical success factors were medical need, timely generation of medical evidence, and the rapid development of robust and precise laboratory assays.
Investigation of the P1′ and P2′ sites of IQF substrates and their selectivity toward 20S proteasome subunits
Authors: Gladysz Radoslaw , Malek Natalia , Rut Wioletta , Drag Marcin 
Published: November 2022

Abstract
High levels of expression and activity of the 20S proteasome have been linked to many types of pathologies, including neoplasia, autoimmune disorders, neurodegenerative diseases and many more. Moreover, distinguishing between 20S proteasome catalytic subunits is neglected, although it may provide further insight into the development of pathologies. Several approaches have been developed to detect 20S proteasome activity, one of which is internally quenched fluorescent (IQF) substrates, which currently suffer from low efficiency and sensitivity. Previous reports focused on peptides including natural amino acids; therefore, in this report, we synthesized and analyzed IQF substrates with both natural and unnatural amino acids in the P1′ and P2′ positions to investigate their influences on selectivity toward 20S proteasome subunits. We found that elongation of the substrate by the P1′ and P2′ positions increased specificity in comparison to tetrapeptides. Moreover, we were able to obtain IQF substrates for the Ch-L subunit, which was characterized by higher selectivity than formerly used tetrapeptides. These findings may further contribute to the development of novel diagnostic tools for 20S proteasome-dependent disorders.
There’s more than one metaverse
Authors: Buchholz Florian , Oppermann Leif , Prinz Wolfgang 
Published: November 2022

Abstract
Will there only be one Metaverse in the future? Since October 2021, many virtual worlds suddenly called themselves “Metaverse”, but is that justified? What is the meaning behind the pervasive term Metaverse? How can it be approached from a pragmatic and research-oriented point of view, and maybe separated a bit from pure marketing? This paper tries to contextualise the term and thereby offer an orientation for readers from different industries. Based on a review of past and present activities, we will propose our own definition of the term Metaverse. This is applied to analyse different application scenarios before the paper continues with a general discussion. In a direct comparison, we will tabulate some worlds that already call themselves a Metaverse and check them against criteria from our own definition. In conclusion, we present relevant focal points for a potential future Metaverse resulting from this comparison.
Estimating complier average causal effects for clustered RCTs when the treatment affects the service population
Authors: Schochet Peter Z. 
Published: November 2022

Abstract
Randomized controlled trials (RCTs) sometimes test interventions that aim to improve existing services targeted to a subset of individuals identified after randomization. Accordingly, the treatment could affect the composition of service recipients and the offered services. With such bias, intention-to-treat estimates using data on service recipients and nonrecipients may be difficult to interpret. This article develops causal estimands and inverse probability weighting (IPW) estimators for complier populations in these settings, using a generalized estimating equation approach that adjusts the standard errors for estimation error in the IPW weights. While our focus is on more general clustered RCTs, the methods also apply (reduce) to nonclustered RCTs. Simulations show that the estimators achieve nominal confidence interval coverage under the assumed identification conditions. An empirical application demonstrates the methods using data from a large-scale RCT testing the effects of early childhood services on children’s cognitive development scores. An R program for estimation is available for download.
Exponential stability of traveling waves for a nonlocal dispersal SIR model with delay
Authors: Wu Xin , Ma Zhaohai 
Published: November 2022

Abstract
This article is concerned with the nonlinear stability of traveling waves of a delayed susceptible-infective-removed (SIR) epidemic model with nonlocal dispersal, which can be seen as a continuity work of Li et al. [Traveling waves for a nonlocal dispersal SIR model with delay and external supplies, Appl. Math. Comput. 247 (2014), 723–740]. We prove that the traveling wave solution is exponentially stable when the initial perturbation around the traveling wave is relatively small in a weighted norm. The time decay rate is also obtained by weighted-energy estimates.
A Reading of Nietzsche’s Revaluation of all Values as a Cynical Dialectic
Authors: Guo Cheng 
Published: November 2022

Abstract
This paper tries to interpret Nietzsche’s revaluation of all values as a dialectical structure of Cynicism. Ancient Cynicism is regarded as the thesis, modern cynicism as its antithesis, namely its decadent form. In recent years this decadence has been somewhat overcome by the attempt to underline a new Cynicism, which can be seen as a synthesis.<fnote> I’m well aware that Nietzsche did not appreciate Hegel. But I find this way of presentation quite convincing in the reading of his revaluation as a dialectical structure. And the dialectical structure is not meant in the Hegelian sense, but in the broader sense of the word. Although Nietzsche strongly criticizes Hegel’s dialectic, one can also find ‘dialectical’ features in his philosophy. The three transformations of the spirit in Thus Spoke
Zarathustra can be understood as a dialectical structure: The camel that obediently carries the heavy old values is considered the thesis. The lion, which no longer respects the old values and creates only freedom, is considered the antithesis. But only the child can create new values and so the final transformation of the spirit is considered the synthesis. Moreover, Oliver Dier sees an inner dialectical movement in Nietzsche’s doctrine of the eternal recurrence (Oliver Dier, Die Verwandlung der Wiederkunft, in: Nietzsche-Studien, 30 (2001), 133–174). According to Werner Stegmaier, the word “great” in late Nietzsche also has a dialectical sense (Werner Stegmaier, Nietzsches Befreiung der Philosophie. Kontextuelle Interpretation des V. Buchs der ‘Fröhlichen Wissenschaft’, Berlin a. Boston 2012, 29). Roberto Esposito considers Nietzsche’s biopolitics to be “inscribed in the dialectic of immunity and community” (Quoted from Vanessa Lemm, Nietzsche and biopolitics: Four readings of Nietzsche as a biopolitical thinker, in: Sergei Prozorov a. Simona Rentea [eds.], The Routledge Handbook of Biopolitics, New York 2017, 50–65; here: 51).</fnote> I then compare Nietzsche’s revaluation of all values with the coin metaphor of Diogenes. The revaluation is close to Cynicism, both in a literary as well as in a philosophical way. The starting point of the revaluation is obviously Cynical. But Nietzsche takes the will to power much further than the Cynics. I subsequently discuss the danger that the revaluation of all values will result in a cynical nihilism and the way Nietzsche overcomes it with his doctrines of the eternal recurrence and the Übermensch. Finally, the paper concludes with the claim that Nietzsche completes his revaluation with his own Cynicism as a synthesis.
Synthesis and characterization of graphene oxide/alginate and application of central composite design in the adsorption of Th(IV) on the nanobiocomposites
Authors: Adman Nildeniz , Yusan Sabriye 
Published: November 2022

Abstract
In this study, graphene oxide and aginate were used to synthesis of nanobiocomposites under different synthesis conditions and the used to investigate the adsorption properties of Th (IV) ions from aqueous solutions. BET surface area, SEM and TEM images, FT-IR spectrometry, XRD techniques were used for the characterization of the adsorbents. In batch adsorption experiments, parameters affecting the adsorption efficiency such as solution pH, contact time, Th (IV) concentration and temperature were investigated using central composite design (CCD). ANOVA (analysis) analysis at the 95% confidence interval of the model applied for the experimental design and the compatibility of this model with the experimental findings were examined. The relevance of the model for the nanobiocomposite prepared by the 1st method is that the P value is <0.05 and the model F value is 23.77 and 39.45 with the 2nd method, respectively. These results show that the regression for this method is statistically high. The correlation coefficient (R
2), which was 95.69% for the 1st method and 97.36% for the 2nd method, indicates a high coordination between the observed values and the estimated values. According to the CCD results, it has been observed that the main effects of the adsorption process with the materials obtained by the 1st method are in the direction of increasing the concentration, while pH, time and temperature do not have a statistically significant effect. In the adsorption process with the materials obtained by the 2nd method, it was observed that the concentration, time and temperature caused an increasing effect. Langmuir, Freundlich and Dubinin–Radushkevich isotherms were used to determine the adsorption model and the constants related to these isotherms were calculated. In addition, the adsorption process was also investigated in terms of thermodynamics.
Decoding the Time Course of Spatial Information from Spiking and Local Field Potential Activities in the Superior Colliculus
Authors: Heusser Michelle R. , Bourrelly Clara , Gandhi Neeraj J. 
Published: November 2022

AbstractPlace code representation is ubiquitous in circuits that encode spatial parameters. For visually guided eye movements, neurons in many brain regions emit spikes when a stimulus is presented in their receptive fields and/or when a movement is directed into their movement fields. Crucially, individual neurons respond for a broad range of directions or eccentricities away from the optimal vector, making it difficult to decode the stimulus location or the saccade vector from each cell’s activity. We investigated whether it is possible to decode the spatial parameter with a population-level analysis, even when the optimal vectors are similar across neurons. Spiking activity and local field potentials (LFPs) in the superior colliculus (SC) were recorded with a laminar probe as monkeys performed a delayed saccade task to one of eight targets radially equidistant in direction. A classifier was applied offline to decode the spatial configuration as the trial progresses from sensation to action. For spiking activity, decoding performance across all eight directions was highest during the visual and motor epochs and lower but well above chance during the delay period. Classification performance followed a similar pattern for LFP activity too, except the performance during the delay period was limited mostly to the preferred direction. Increasing the number of neurons in the population consistently increased classifier performance for both modalities. Overall, this study demonstrates the power of population activity for decoding spatial information not possible from individual neurons.
Calnexin reveals a sugar‐free taste within the lipid bilayer
Authors: Guay Kevin P , Williams Robert V , Hebert Daniel N 
Published: November 2022

Maturation of membrane proteins is complicated by the need to fold in three distinct environments. While much is known about folding in the two aqueous milieus constituted by cytoplasm and ER lumen, our knowledge of the folding, arrangement, and quality control of transmembrane regions within the lipid bilayer, and its facilitation by molecular chaperones, is limited. New work by Bloemeke et al now reveals an expanded role of the ER chaperone calnexin acting within the lipid bilayer in a carbohydrate‐independent manner.
Advertising and Young People’s Critical Reasoning Abilities: Systematic Review and Meta-analysis
Authors: Packer Jessica , Croker Helen , Goddings Anne-Lise , Boyland Emma J. , Stansfield Claire , Russell Simon J. , Viner Russell M. 
Published: November 2022

BACKGROUND AND OBJECTIVES
Young people are exposed to an abundance of advertising for unhealthy products (eg, unhealthy foods, tobacco, alcohol). Because of their developing cognition, children may not be able to understand the intent of advertising. However, advertising restrictions often assume that adolescents have critical reasoning capacity and can resist the effects of advertising. This review seeks to assess whether the evidence supports this assumption.

METHODS
Ten databases were searched in December 2020. Inclusion criteria were participants aged 6 to 17 years, any advertising exposure, objectively measured understanding or attitudinal outcome, a comparison, control, and between-group comparison. This study included all languages and excluded studies published pre-2010. Two reviewers independently extracted data and assessed study quality.

RESULTS
Thirty-eight articles were included. Meta-analysis of 9 studies with attitudinal outcomes indicated that unhealthy product advertising generated more positive brand or product attitudes compared with neutral or no advertising control in all ages. There were significant effects for digital and nondigital advertising formats. We found greater understanding did not protect against the impact of advertising on brand or product attitudes. Limitations include the inability to meta-analyze the impact of advertising on understanding or the influence of age.

CONCLUSIONS
Evidence shows that the attitudes of young people were influenced by advertising. Critical reasoning abilities did not appear to be fully developed during adolescence and not found to be protective against the impact of advertising. Policymakers should ensure regulations to restrict marketing of unhealthy commodities protects adolescents as well as younger children.
Diversity of soils in areas with the presence of Furcraea sp. in tropical ecosystems
Authors: Medina-Cano Clara Inés , Vásquez-Gallo Luz Adriana , Tamayo-Vélez Álvaro de Jesús , Vargas-Arcila María , Henao-Rojas Juan Camilo 
Published: November 2022

Introduction. The fique, “cabuya” or “mecate” are the common names given to the species of the genus Furcraea that are used for the manufacture of biodegradable fibers. Their industrial and social importance in Latin American countries is significant since it is usually related to family and peasant economies. However, for this taxonomic group, the diversity of edaphic conditions in natural habitats or cultivation sites is unknown. Objective. To physicochemically characterize the soils in the productive systems and natural populations of fique, to determine the aspects and factors that best represent their variability. Materials and methods. The work was developed between 2013 and 2014, in 66 municipalities and 108 villages in 11 departments of Colombia. Passport data was recorded at the 121 sites visited, describing site conditions, including georeferencing. In each locality, soil samples were taken in the first 20 cm of depth and subsequently the following variables were determined: texture, pH, organic matter (OM), P, S, K, Mg, Ca, Al+H, CE, cations of change Ca, Mg, K, Na, cationic exchange capacity (ECEC), Ca, Mg, K, and Na. According to georeferencing, 52 agroecological zones were identified. Results. Populations located between 170 to 2,993 m.a.s.l. were found. The most significant factors were agroecological zone and soil texture. Among them, texture was the factor with the greatest capacity for group formation and represented 60.99 % of the variability of the sampled soils. The variables that most contribute to the variability of the soils were (Ca + Mg) / K, exchangeable Mg, K / Mg, exchangeable Ca, and ECEC. Conclusion. The results obtained for wild and cultivated populations indicate that the different taxa survive in diverse tropical soil conditions. It was found that the exchangeable ions had high discriminating power that could indicate diversity to the different conditions and fertility levels of Colombian soils.
A simple, rapid, sensitive and eco-friendly LC-MS/MS method for simultaneous determination of free cordycepin and isocordycepin in 10 different kinds of Cordyceps
Authors: Li Wenqing , Qian Zhengming , Zou Yuansheng , Tan Guoying , Li Wenjia , Lei Qinggui , Li Runfeng , Lan Dongming 
Published: November 2022

AbstractA simple, rapid, sensitive and eco-friendly liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for simultaneous determination of free cordycepin (3′-deoxyadenosine) and isocordycepin (2′-deoxyadenosine) in 10 kinds of Cordyceps samples. The samples were prepared by ultrasonic extraction at 75 °C for 30 min with boiling water as the extraction solvent. The LC separation was performed on an Agilent poroshell 120 SB-Aq C18 column (3.0 × 50 mm, 2.7 μm) in isocratic mode with an eco-friendly mobile phase (2% ethanol containing 0.2% acetic acid) at a flow rate of 0.6 mL min−1, and detected by MS/MS in positive mode with multiple reaction monitoring (MRM). The developed method showed good linearity (r > 0.9990), sensitivity (LODs = 0.04 pg, LOQ = 0.1 pg), precision (RSD ≤ 3.8%) and stability (RSD ≤ 3.6%). The recoveries of developed method were 94.4–109.5% (RSD ≤ 5.5%). Compared with reported methods, the current method was rapid (less than 35% analytical time), sensitive (more than 5 folds), and eco-friendly (less than 10 μL harmful organic solvent). 10 different kinds of Cordyceps samples (40 batches) were tested by the developed method. Codycepin was only found in Cordyceps millitaris and C. millitaris fruiting body, and isocordycepin was detected in Cordyceps sinensis and other 6 Cordyceps samples. The developed method would be an improved method for the quality evaluation of Cordyceps samples.