bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between RSA and CAST-128 with Adaptive Key for Video Frames Encryption with Highest Average Entropy
Authors: Khudair Enas Tariq , Naser Ekhlas Falih , Mazher Alaa Noori 
Published: May 2022

Encryption of data is translating data to another shape or symbol which enables people only with an access to the secret key or a password that can read it. The data which are encrypted are generally referred to as cipher text, while data which are unencrypted are known plain text. Entropy can be used as a measure which gives the number of bits that are needed for coding the data of an image. As the values of pixel within an image are dispensed through further gray-levels, the entropy increases. The aim of this research is to compare between CAST-128 with proposed adaptive key and RSA encryption methods for video frames to determine the more accurate method with highest entropy. The first method is achieved by applying the "CAST-128" and the second is achieved by applying the "RSA ". CAST-128 utilizes a pair of sub-keys for each round as a quantum of five bits that was utilized as a key of rotation for each round and a quantum of 32 (bits) was utilized as a key of masking into a round . The proposed adaptive 128-bits key can be extracted from the main diagonal of each frame before encryption. RSA is a public-key cryptographic technique which can be known as (asymmetric) cryptography. An asymmetry of a key depends on factoring a product of two big prime values. A comparison was applied on several videos and the results showed that CAST-128 method proved the highest degree of entropy even if the frames have lots of distorted data or unclear image pixels. For example, the entropy value of a sample of a girl video is 2581.921 when using CAST-128, while it is 2271.329 when using the RSA; also the entropy value of a sample of a scooter video is 2569.814 when using the CAST-128, while it is 2282.844 when using RSA.
Investigation of the association of AGTR1 A1166C rs5186 and FTO rs9939609 polymorphisms with the obesity in children and adolescents
Authors: Hashim Abd Ali Alaa , D. Teplyakova E. , V. Bocharova O. , V. Karantysh G. , P. Shkurat T. 
Published: May 2022

Obesity is a risk factor for a number of chronic conditions. Obesity is clinically defined using the body mass index (BMI) as weight in kg divided by (height)2 in m2 correlated with obesity. Currently, genetic markers of obesity are being studied. This study focused on the association between the angiotensin II receptor AGTR1 gene (A1166C) and fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase (FTO) (rs9939609) in obese children and adolescents patients in Rostov region, Russia. Five-hundreds of Russian nationality child and adolescent were recruited for the obesity-control studies. The relationship between the A1166C polymorphism of the AGTR1 gene in 300 children and adolescents included as the unhealthy group, compared with healthy group of 200 participants were investigated. Genotyping of A1166C polymorphisms of the AGTR1 rs5186 gene was performed using PCR allele-specific primers. Polymorphisms of the AGTR1 A1166C (rs5186) genes in donor DNA samples were typed by the electrophoretic method using commercial test systems from the Lytech research and production company. The relationship between obesity and AGTR1 gene polymorphism (A1166C) was not established between the obesity and control groups in terms of the frequency of occurrence of the CC genotype (P = 1.000) and (OR 1.05; 95% CI (0.53 – 2.10)) and the C allele (P = 0.942) and (OR 1.01; 95% CI (0.76 – 1.35)). However, in the occurrence of frequency genotype of AA (P = 0.003; OR 0.57; 95% CI (0.39 – 0.82)) and T (P = 0.006) of allele and (OR 1.44; 95% CI (1.11 – 1.87)) the rs9939609 of the FTO gene were revealed differences (P <0.05) between patients and control groups. The association between genotypes obesity risk was indicated, and a significant relationship was shown between the occurrence of obesity with the FTO rs9939609 polymorphism.
Effectiveness of a training intervention to improve the management of vertigo in primary care: a multicentre cluster-randomized trial.
Authors: Patiño Jenniffer Elizabeth Pérez , Moreno Jose Luis Ballve , Matos Yolanda Rando , Ortega Jesús Almeda , Puértolas Oriol Cunillera , Muñoz Ricard Carrillo , Balboa Ivan Villar , Compta Xavier González , Agudelo Olga Lucia Arias , Muñoz Sebastiá Calero , Rodríguez Vanessa Monforte , Cortes Anna Navarro , Rodríguez Eva Peguero 
Published: May 2022

Abstract
BackgroundBenign paroxysmal positional vertigo (BPPV) is the most common type of vertigo. While BPPV is best treated with canalicular repositioning maneuvers, they are not routinely performed in primary care (PC). MethodologyObjectives:To evaluate the effectiveness of blended training (online and face-to-face) on the diagnosis and management of vertigo to improve adherence of family doctors to clinical practice guidelines.DesignCommunity multicenters cluster-randomized open-label trial with an intervention (IG) and a control group (GC) of 10 primary care teams (PCTs) each.MeasurementsOutcome variables will be: ICD-10 diagnostic codes (proportion of nonspecific diagnoses such as dizziness and vertigo versus specific diagnoses such as BPPV, vestibular neuritis and Meniere's syndrome); referrals to ENT and neurology specialists; prescription of antivertigo agents; duration of sick leave due to vertigo.Statistical analysis The baseline comparability of the two study groups will be analysed to ensure homogeneity. A description of all baseline variables will be performed. Student’s t-test will be used to evaluate differences between groups. Logistic regression multivariate analysis will be performed to study the relationship between baseline variables of professionals and centers with outcome variables.ClinicalTrials.gov Identifier: NCT04929444. Registered June 18, 2021, https://clinicaltrials.gov/ct2/show/NCT04929444EthicsThis protocol has been approved by the Ethics Committee of the Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol) with the code 20/004-P. All patient data will be anonymised in agreement with the 2016/679 European Regulation. Expected results and Applicability With the improvement of the diagnosis and management of vertigo by family doctors after this training we expect: an increase in the proportion of specific diagnoses; a decrease in the prescription of antivertigo agents; a decrease in the request for complementary tests and referrals to other specialists; a reduction in the duration of sick leave due to temporary disability. The blended training will be easily expanded within primary care services, since it is mainly delivered online, with a single face-to-face session to ensure that the maneuvers have been adequately learned.
Begining of integration RATP model in LASER/F for thermo-radiative simulation of an urban district with vegetation
Authors: Chakkour Tarik 
Published: May 2022

Abstract
LASER/F is designed to simulate the energy budget of the urban climate. This model has been developed for the needs of urban climate research. The framework of the model is described in this paper. This article deals with simulating radiative fluxes and distribution of the radiative energy in an urban canyon. Specific algorithms involving in these computations are presented. When vegetation is present on the ground, the transpiration is slightly underestimated using it. On the other hand, the model RATP simulates well the spatial distribution of radiation and leaf-gas exchanges within vegetation canopies as a function of canopy microclimate. The aim of the paper is to improve some geometric procedures used in LASER/F in order to obtain globally a good level of performance. Coupling these models stays chalenging and complicated. Then, we will consider the influence of urban planning and in particular the influence of urban vegetation in the model.
Fluorescent aptamers modified mesoporous silica nanoparticles for quantitative detection of acetamiprid
Authors: He Kangli , Yang Jinghan , Shi Qiuyun , Guan Lingjun , Sun Li , Chen Zhiyang , Feng Jianguo , Dong Sa 
Published: May 2022

Abstract
Acetamiprid (ACE) is widely used to control aphids, brown planthoppers and other agricultural pests. However, its difficulty in degrading in the environment leads to pesticide residue contamination, acute and chronic toxicity to humans and their non-target organisms. Therefore, the development of a fast, convenient and highly sensitive method to quantify ACE is essential. In this paper, a simple and sensitive fluorescence analysis method for the rapid detection of ACE was constructed by preparing aminated mesoporous silica nanoparticles (MSNs-NH2) by one-pot method and adsorbing a 6-Carboxyfluorescein modified aptamer of ACE (FAM-Apt) on its surface by electrostatic interaction. In the absence of ACE, the negatively charged FAM-Apt binds electrostatically to the positively charged MSNs-NH2, due to gravity MSNs-NH2@FAM-Apt is centrifuged to form a precipitate and no fluorescent signal is detected in the supernatant. Conversely, the specific combining of FAM-Apt to insecticides was greater than the electrostatic interaction with MSNs-NH2, FAM-Apt was separated from MSNs-NH2 and a high fluorescence signal was obtained in the supernatant. For ACE detection, the linear range was 50-1100 ng/mL, and calculated the detection limit (LOD) of ACE was 30.26 ng/mL. The method performs well in practical sample analysis applications with good sensitivity, selectivity and reproducibility, providing a reference for rapid and low-cost detection of ACE.
Effects of Slider, Tensioner Neurodynamic Mobilization Techniques and Stretching Exercises in Treatment of Chronic Discogenic Sciatica: A Comparative Study
Authors: Morsi Haytham Ibrahim , Nahass Bassem Galal Eldein El , Ibrahim Mona Mohamed 
Published: May 2022

Abstract
Background: Sciatica is a critical musculoskeletal disorder affecting many people and its related disabilities disturb their lives. Methods: The study purpose was to see which one of two neurodynamic techniques and stretching exercises has a better effect on improving symptoms and dysfunction for cases of sciatica due to disc herniation. There were 36 unilaterally affected participants. They were assigned at random into three groups; participants in the first were treated by the slider technique, while participants in the second were treated by the tensioner technique, and participants in the third were treated by stretching. The treatment program was set to be 6 successive sessions in 2 weeks. The therapist assessed the participants pre and post-program.Results: The statistical analysis revealed that there were significant differences in favor of the slider and tensioner techniques compared with stretching. Furthermore, there were found significant differences in favor of the slider as compared to the tensioner technique regarding range of motion (ROM).Conclusion: Slider and tensioner techniques have better clinical results than stretching exercises in improving symptoms and dysfunction with a greater effect for the slider technique in enhancing ROM.Trial registration: This study was executed under the ethical guidelines of 1964 declaration of Helsinki and was registered in the clinical trial registry with clinical trial.gov on 10/02/2021, ID: NCT04746690.
Lipidomics profiling to reveal the restorative effect of moisturizer in OICD patients
Authors: Fan Ke-liang , Mao Zhen-Xing , Wang Jia , Xu Qing-qing , Liu PengLing , Wang Juan , Wei Dan Dan , Wang Chong-Jian , Yan Lei , Chen Yuanyuan , Zhou Lihong , Yuan Chao , Chen Tian 
Published: May 2022

Abstract
Background
Occupational irritant contact dermatitis (OICD) usually manifests as impaired skin barrier function. The composition of the skin surface lipids (SSLs) determined the skin barrier function. This study aims to evaluate the repair effect of moisturizer on the skin barrier function of OICD patients and lipidomic tools were used to explore potential repair mechanisms.
Methods
A self-controlled study based on occupational shampoo workers was conducted in Zhengzhou, China, in December 2019. The study lasted 2 weeks in total, and subjects with OICD symptoms applied moisturizing cream during the study. Skin moisture content and trans epidermal water loss (TEWL) values were used as secondary indicators, and SSLs were used as main indicators to evaluate the recovery effect of subjects' skin barrier function after the intervention.
Results
After using moisturizer for 2 weeks, skin moisture increased significantly (p < 0.001), and TEWL decreased. A total of 635 SSLs were detected and classified into 5 main classes. The relative abundance of all lipids increased. Long-chain fatty acids, glycerolipids (mainly triglycerides), and cholesterol lipids were the major lipid species repaired after 1 week of intervention. Glycerophospholipids as the main lipid were repaired after 2 weeks of intervention.
Conclusion
Moisturizer could be used as an effective intervention to increase SSLs and repair skin barrier function to a certain extent in OICD patients.
Trial registration:
This study was reviewed and approved by Zhengzhou University's Life Science Ethics Review Committee and Registered in the Chinese Clinical Trial Registry (ID: ChiCTR2000034103). Informed consent from participants was obtained before enrollment.
Symptoms of Anxiety and Depression within the UNiversity community: the cross-sectional UN-SAD study
Authors: Scarpis Enrico , Pin Massimo Del , Ruscio Edoardo , Tullio Annarita , Brusaferro Silvio , Brunelli Laura 
Published: May 2022

Abstract
The increasing complexity of academia, with its demanding working conditions and uncertain career opportunities, may affect the mental health of academics and potentially lead to mental health problems. This study aims to determine the prevalence of depression and anxiety symptoms in the academic population of the University of Udine, comparing symptoms in senior and younger academics and administrative staff.A cross-sectional survey was conducted between June and December 2020, involving all academic and administrative staff from all departments. The prevalence of depressive and anxiety symptoms was assessed using the PHQ-9 and GAD-7 tools. The relationship between mental health outcomes and job role was analyzed using nonparametric tests and ordinal logistic regression.A total of 366 individuals participated: 109 junior academics, 146 senior and 111 administrative staff. The proportion of women was 55.7% and the mean age was 47.9 years. Compared to administrative staff and senior academics, junior academics had a higher prevalence of depressive (39.4% vs 14.4% vs 27.0%; p<0.001) and anxiety symptoms (33.0% vs 15.1% vs 22.5%; p<0.005). Univariate models suggest a lower risk for anxiety symptoms OR 0.53 (0.31-0.88) for men.The prevalence of depressive symptoms is higher in our academic community than in the general population, particularly among junior academics. These findings may represent the impact of uncertain career and challenging environment on the mental health of young academics. Universities should provide more support to young academics so that they can contribute effectively and healthily to the advancement of research.
Protein of Interest Synthesis Using Non-formylated Methionine−Escherichia coli initiator tRNA in HeLa cells
Authors: ‍Kim Jung Min , Kang Young Mi 
Published: May 2022

Abstract
In eukaryotic cells and Escherichia coli, protein synthesis is initiated through non-formylated and formylated methionine-conjugated initiator tRNA (Met-tRNAi and fMet-tRNAi, respectively). Studies have shown that protein of interest (POI) reduced EGFP mRNA expression in human Met-tRNAi/human methionyl-tRNA synthetase (HMRS) pairs under methionine-deficient conditions. Intracellular L-Met depletion can result in the inhibition of endogenously non-formylated human Met-tRNAi/HMRS in HeLa cells. We investigated the effect of non-formylated Met-conjugated E. coli initiator tRNA (E. coli Met-tRNAi) on POI synthesis in HeLa cells under intracellular L-Met levels. The expression of GFP—a model protein—in L-methionine-deficient HeLa cells, in which endogenous tRNAi was replaced with two kinds of E. coli tRNAi, E. coli Met-tRNAi/E. coli methionyl-tRNA synthetase (EcMRS) and E. coli Met-tRNAi/HMRS, was analyzed. The results indicated that E. coli Met-tRNAi can offset human Met-tRNAi, and E. coli methionyl tRNA synthetase (EcMRS) can drive the expression of EGFP mRNA. The non-formylated E. coli Met-tRNAi/EcMRS pairs reduced the expression of EGFP mRNA, resulting in reduced HeLa cell survival. Our results provide new insights into the potential use of E. coli Met-tRNAi as novel therapeutics that can control POI synthesis initiation. The E. coli Met-tRNAi/MRS pair has the potential to fine-tune protein synthesis in mammalian cells.
QSRR modeling of the chromatographic retention behavior for some quinolone and sulfonamide antibacterial agents using firefly algorithm coupled to support vector machine
Authors: Fouad Marwa A. , Tolba Enas H. , El-Shal Manal A. , Serag Ahmed , Kerdawy Ahmed M. El 
Published: May 2022

Abstract
Quinolone and sulfonamide are two classes of antibacterial agents that have an opulent history of medicinal chemistry features responsible for their improving bacterial spectrum, efficacy, pharmacokinetics, and adverse side effect profiles. The urgent need of their use and escalating rate of their resistance provokes the necessity for developing suitable analytical methods that speed up and facilitate their analysis. In this study, advanced firefly algorithm (FFA) coupled with support vector machine (SVM) were used to select the most significant descriptors and to construct two separate quantitative structure–retention relationship (QSRR) models using a series of 11 selected quinolones and 13 sulfonamide drugs, separately, in order to predict their retention factors in HPLC. Precisely, the effect of different pH range values and acetonitrile composition in the mobile phase on the retention behavior of quinolones and sulfonamides were studied, respectively. The obtained QSRR models showed high performance in both internal and external validation indicating their robustness and predictive ability. Y-randomization validation displayed that the obtained models are not obtained by chance. Besides, the obtained results shed the light on the molecular features that influence the retention behavior of these two classes under the current chromatographic conditions.
Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis
Authors: Guo Changcheng , Sun Yin , Zhai Wei , Yao Xudong , Gong Dongkui , You Bosen , Huang Chi-Ping , Zheng Junhua , Chang Chawnshang 
Published: May 2022

Abstract
Background： Early studies indicated that the androgen receptor (AR) could promote renal cell carcinoma (RCC) development and metastasis, but its linkage to RCC progression under hypoxia, remains unclear. Results: Here we found AR expression in RCC cells decreased in response to hypoxia, which might then lead to increase the cancer stem cells (CSC) phenotype through the lncTCFL5-2-modulated YBX1/SOX2 signals. The consequences of such hypoxia-modulated AR/lncTCFL5-2/YBX1/SOX2 signals to alter CSC phenotype might render RCC cells more resistant to targeted therapy with Sunitinib. Mechanism dissection revealed that AR might alter the lncTCFL5-2/YBX1/SOX2 signaling through transcriptional suppression of the lncTCFL5-2 expression via the AR-response-elements (AREs) on the lncTCFL5-2 promoter. The lncTCFL5-2 interacts with YBX1 to increase its stability, which in turn increases SOX2 expression at a transcriptional level via the YBX1-response-elements (YBX1Es) on the SOX2 promoter. The in vivo mouse model with orthotopic xenografts of RCC cells also validates the in vitro data, and a human RCC sample survey demonstrated the clinical significance of the AR/lncTCFL5-2/YBX1/SOX2 signaling axis for the RCC prognosis, likely as a result of regulating CSC phenotypes. Conclusions: Together, these findings suggest that hypoxia may increase the RCC CSC phenotype via altering the AR/lncTCFL5-2/YBX1/SOX2 signaling axis and a potential therapy to target this newly identified signal perhaps may help improve the targeted therapy with Sunitinib to better suppress RCC progression.
Design and baseline description of an observational population-based cohort study on COVID-19 vaccine effectiveness in the Netherlands - The VAccine Study COvid-19 (VASCO)
Authors: Huiberts Anne J. , Kooijman Marjolein N. , de Melker Hester E. , Hahne Susan J. , Grobbee Diederick E. , Hoeve Christel , Binnendijk Rob van , Hartog Gerco den , de Wijgert Janneke H.H.M. van , Hof Susan van den , Knol Mirjam J. 
Published: May 2022

Abstract
VAccine Study COvid-19 (VASCO) is a cohort study with 5-year follow-up to assess the real-world vaccine effectiveness (VE) of COVID-19 vaccines in the Netherlands. VASCO was initiated when COVID-19 vaccination was introduced in the Netherlands. The primary objective is to estimate vaccine-specific VE against symptomatic SARS-CoV-2 infection, overall and in four subpopulations defined by age and medical risk, at 9 months after study start when most participants would have accumulated at least 6 months of follow-up. Secondary objectives are to estimate VE by time since vaccination and by severity of SARS-CoV-2 infection. Between May and December 2021, 45,271 participants aged 18–85 years have been enrolled in VASCO. Participants were included irrespective of their COVID-19 vaccination status or intention to get vaccinated. At inclusion, at 6, 12, 24, 36, 48 and 60 months after inclusion, and at one month after primary vaccination, participants are asked to take a self-collected fingerprick blood sample at home. In the serum samples, nucleoprotein (N) and spike protein receptor binding domain (RBD)-specific antibody titers are assessed to determine vaccine response and prior SARS-CoV-2 infection(s), including prior asymptomatic infections. Participants are also asked to complete monthly digital questionnaires in the first year, and 3-monthly in years 2–5, including questions on sociodemographic factors, health status, COVID-19 vaccination, SARS-CoV-2 related symptoms and testing results, and behavioral responses to COVID-19 measures. The main aim of VASCO is to contribute to policy decision-making regarding future COVID-19 vaccination. Furthermore, VASCO provides an infrastructure to conduct substudies in response to unforeseen developments within the COVID-19 pandemic.
Triglyceride glucose-waist circumference to height ratio predicts 10-year diabetes risk: the REACTION research
Authors: Lin Jie , Li Hang , Qin Yahui , Xiang Xin , Wan Qin 
Published: May 2022

Abstract
Objective: Although the triglyceride glucose-waist-to-height ratio (TyG-WHtR) is an indicator of insulin resistance, the relationship between TyG-WHtR and newly diagnosed diabetes is unclear. The aim of this research was to examine the causative association between TyG-WHtR and newly diagnosed diabetes.Patients and measurements: We organized a retrospective 10-year cohort study of 10150 Chinese adults. After screening out people who were not qualified, the TyG-WHtR level of 8279 participants was calculated in this study. A multivariate logistic regression model was used to investigate the possibility that it has a connection with diabetes.Results: Within 10 years, 271 men (3.27%) and 532 women (6.43%) had new-onset diabetes. The TyG-WHtR index and newly diagnosed diabetes mellitus had a linear correlation, according to multivariate Cox regression analysis (HR = 2.186, 95% CI: 1.873 to 2.551, P < 0.001), and TyG-WHtR had a good AUC (0.750, 95% CI: 0.733-0.767). Additionally, TyG-WHtR-associated diabetes was substantially more prevalent in people aged 71 to 80, with a BMI below 18.5 kg/m2 and no hypertensive condition (P < 0.05).Conclusions : TyG-WHtR might be an accurate indicator of future diabetes risk and outperform other commonly used anthropometric indices.