bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative Approach to Maximizing Completion Drill Bit Longevity
Authors: Lyles Dustin , Devers Cameron , Dyer Warren , Lyles Shawn 
Published: September 2022

Abstract
For almost a decade, the predominant completion drill-out bits utilized to drill composite frac plugs were roller-cone (RC) bits incorporating "hybrid" cutting structures. RC hybrid cutting structures consist of various layouts incorporating a combination of milled teeth (MT) and tungsten carbide insert (TCI) cutting elements that exhibit known trade-offs regarding longevity and performance. The objective of this paper is to illustrate how practicing engineers can, and should, question status quo to overcome traditional design/performance limiters. Extensive analysis of hybrid RC dull bits and performance data was conducted with the goal to advance RC completion drill bit longevity and performance while reducing non-productive time (NPT). Through quantifying and classifying cutting structure damage across 30 RC hybrid drill bits, data collected clearly illustrated which portions of the bit profile and cutting elements were sustaining the most damage. The data indicated commonly accepted hybrid RC designs display an inherent weakness that would require questioning common beliefs about completion RC bit design and manufacturing methodologies. A new bit design was developed and extensively field tested. The results of the dull bit evaluation indicated the MT are inherently less robust and result in more performance limiting cutting structure damage. The MT have been utilized as a standard due to industry acceptance, manufacturing limitations associated with implementing the more robust TCI's in all portions of the bit profile and perceived benefits with MT geometry. Implementing full TCI coverage to mitigate cutting structure damage required rethinking longstanding manufacturing methods and cutting element selection that have been accepted as industry standards. Changes in manufacturing methodology required increasing surface hardness of the cone face around TCI's to avoid loss due to interaction with slip debris and/or weakened TCI retention due to erosion. This change required a substantial and challenging shift in heat-treating methods and manufacturing workflow. Further changes were made to the TCI geometries in the new design to ensure the aggressiveness needed to fail soft composite plug materials into small debris sizes was equivalent or better than the MT cutting elements. The manufacturing, material and geometric changes resulted in a solution that contradicted previous trade-off understandings regarding completion drill bits by simultaneously improving durability and aggressiveness. The work exemplifies the importance for practicing engineers continuously to question status quo in pursuit of continuous improvement even when faced with longstanding beliefs and/or methodologies. Furthermore, the findings from the project give insight into completion drill-out trends and opportunities to reduce NPT and improve efficiency.
Multilateral Technology Enables Record Reservoir Contact in North Sea Subsea Well
Authors: Kelsey Matthew , Fanchin Thomas , Van Der Veen Steffen , Dahl Espen , Harila Skjold Kristina 
Published: September 2022

Abstract
In the 1990's many oil plays in the North Sea were originally deemed uneconomical due to the limited technology available to address the associated challenges. Horizontal and eventually multilateral applications were introduced to address this challenge. For over two decades multilateral technology has extended the production life of these fields by continuing to evolve to meet the demands of increasingly complex subsea applications.
Over this history, multilateral applications have evolved from dual-laterals with standalone screens and commingled flow to tri-lateral and quad-lateral intelligent completions as common multilateral completion strategies in the North Sea. A significant number of wells originally completed as a dual-lateral have since been recompleted twice or even three times to produce reserves previously left behind.
As investment and availability of new fields decline, operators face challenges to extend the production life of mature fields while also working to reduce overall development cost, cycle times, and carbon footprint. Further challenges include delivery of wells and facility systems using less in-field construction hours at a lower baseline cost.
This paper will focus on the evolution of a mature well in a region that has been installing multilateral wells for over two decades. Originally drilled as the world's first tri-lateral well and several years later re- drilled again as a quad-lateral to add further reservoir contact. As production decline and strategic targets esteemed to be more profitable are within reach from the same template, further re-drills as a dual-lateral and then a further quad-lateral has been utilized to add significant reservoir contact for further economic production.
It highlights the technology used to keep this well on production for over two decades and the benefits of expanding the use of this technology as fields become slot restricted. It also highlights the benefits this technology delivers in significantly increasing reservoir exposure and the time savings brought by drilling new lateral legs in existing subsea wells. The case study will include discussion of workover operations, completions, isolation methods, and lateral creation systems.
Through four separate multilateral installations in one subsea slot, the production life has been extended beyond 20 years. The paper also provides insight as to methodology for continually improving reliability of multilateral installations to maximize efficiencies.
Multi-criteria Fitness Function based Genetic Optimization of AODV Routing Protocol in MANETs
Authors: Mehta Ridhima 
Published: September 2022

Abstract
The artificial intelligence search techniques are widely used to achieve performance enhancement in wireless communication systems. One such methodology of evolutionary genetic programming inspired by nature is essentially appropriate for optimized operation in the context of wireless multi-hop ad-hoc networks with several challenges to provide the necessary network services. In this paper, we develop a reliable and efficient data routing scheme employing the conventional AODV protocol based on the dynamic genetic algorithm. It is aimed at effectively allocating the scarce radio resources and improving the QoS among the wireless devices in MANETs by joint optimization of network attributes including the data transfer rate, link transmission power and round trip delay. The proposed genetic algorithm based routing scheme utilizes two different fitness functions, together with binary data coding and decoding, single-point crossover and random mutation operators to assess the fitness measure of the specific solution space and network operational characteristics. This computational learning method is trained through the sample dataset obtained via the simulation experiments of the basic AODV routing scheme. With the emerging size of the sample network data records, the deployed polynomial and logarithmic fitness functions are compared in terms of power consumption and delay metrics to design a robust and adaptive data communication scheme. Finally, our smart network data learning and genetic optimization model is compared with the previous related models to demonstrate its improved performance in terms of lower power consumption, higher throughput, and greater values of average fitness measure.
Evaluation of the safety and efficacy of tripterygium wilfordii glycosides for patients with primary sjgren's syndrome : protocol for a prospective, double-blinded, randomized, placebo-controlled clinical trial
Authors: Ju Yanjuan , Li Rongping , Dong Xiaofan , Zhou shenghui , Hu Jin , Guo Dibin 
Published: September 2022

Abstract
Background: As a common autoimmune disease, primary sjogren's syndrome(pss) has limited therapeutic agents. For some patients with Sjogren's syndrome complicated with serious complications, taking glucocorticoid combined with cyclophosphamide treatment can obtain good results. However, the side effects of long-term use of glucocorticoid and cyclophosphamide limit its application in patients without extraglandular manifestations. Some animal experiments have shown that tripterygium wilfordii polyglycosides tablets have immunomodulatory effects. The immunomodulatory function of Tripterygium polyglucoside was found in some animal experiments. Some Single center, small sample, non-randomized control studys have proved that tripterygium wilfordii glycosides can allevitate dry eye,dry mouth and serological immunological abnormalities in the patients with PSS .Therefore, we designed this research to study the effect of tripterygium wilfordii glycosides for patients with primary sjgren's syndrome by measuring the reduction of serum globulin,IgA、IgG、IgM、TNF – α，as well as the extent of dry eye and mouth.
Methods : This study is a 12-week, single-center, prospective, double-blinded, randomized, placebo-controlled clinical trial developed from July 2022 to December 2023. Forty individuals with Primary Sjögren’s syndrome without extraglandular manifestations will be recruited and randomly assigned to receive tripterygium wilfordii glycosides or a placebo，and each group will have 20 subjects. During the 12-week observation period, there will be 4 visits. The decline in serum immunoglobulin IgG, IgM, IgA and tumor necrosis factor –α is the main outcome measure, and change of dry mouth, dry eye : Natural saliva flow rate、Schirmer's test、Tear break-up time and Adverse reactions: damage of blood system, liver and kidney function are the secondary outcome measures.
Discussion: This study will probe the effect of tripterygium wilfordii glycosides in the treatment of pSS and explore possible therapeutic mechanisms. By performing this trial, we hope to provide evidence and data to support further large clinical studies.
Trial registration: Chinese Clinical Trial Registry ChiCTR2200062262. Registered on 31 July 2022.http://www.chictr.org.cn/edit.aspx?pid=175924&htm=4
The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice
Authors: Roussel Julien , Larcher Romaric , Sicard Pierre , Bideaux Patrice , Richard Sylvain , MARMIGERE Frederic , Thireau Jérôme 
Published: September 2022

Abstract
Recent understanding of Autism Spectrum Disorder (ASD) showed that peripheral primary mechanosensitive neurons involved in touch sensation and central neurons affected in ASD share transcriptional regulators. Mutant mice for ASD-associated transcription factors exhibit impaired primary tactile perception, and restoring those genes specifically in primary sensory neurons rescue some of the anxiety-like behavior and social interaction defects. Interestingly, peripheral mechanosensitive sensory neurons also project to internal organs including the cardio-vascular system, and an imbalance of the cardio-vascular sympatho-vagal regulation is evidenced in ASD and intellectual disability. ASD patients have decreased vagal tone, suggesting dysfunction of sensory neurons involved in cardio-vascular sensing. In light of our previous finding that the ASD-associated Meis2 gene is necessary for normal touch neurons development and function, we investigated here if its inactivation in mouse peripheral sensory neurons also affects cardio-vascular sympatho-vagal regulation and baroreflex. Combining echocardiography, pharmacological challenge, blood pressure monitoring and heart rate variability analysis, we found that Meis2 mutant mice exhibited a blunted vagal response independently of any apparent cardiac malformation. These results suggest that defects in primary sensory neurons with mechanosensitive identity could participate in the imbalanced cardio-vascular sympatho-vagal tone found in ASD patients, reinforcing current hypotheses on the role of primary sensory neurons in the etiology of ASD.
Comparative safety of infliximab and adalimumab on pregnancy outcomes of Women with Inflammatory Bowel Diseases: A Systematic Review &amp; Meta-Analysis
Authors: Wang Han , Hu Yue , Chen Fang , Shen Mengdie 
Published: September 2022

Abstract
Background
Inflammatory bowel disease (IBD) is a condition that affects most of the digestive tract. There is no report of fertility reduction in medically managed IBD women compared with the general population. On the other hand, active IBD can lead to significantly decreased fertility. Over the previous 2 decades, anti-tumor necrosis factor (anti-TNF) has been an effective treatment for managing patients with Crohn's disease, increasing the use of infliximab and adalimumab in clinical practice. However, it is unclear which biologics are more effective in pregnant women with IBD.
Aim
We conducted a systematic review and meta-analysis for the risk of adverse pregnancy outcomes following treatment with infliximab and adalimumab in women with IBD.
Methods
Bibliographic databases were retrieved from their inception to July 2022. The results were adverse pregnancy outcomes, including congenital malformations and spontaneous abortion.
Results
A total of 8 studies included 527 pregnant women with IBD. Of these, 343 received infliximab, and 184 received adalimumab therapy. Compared to adalimumab, adverse pregnancy outcomes were not increased in infliximab therapy.
Conclusion
Infliximab and adalimumab therapy did not show the difference of risk in adverse pregnancy outcomes such as congenital malformations and spontaneous abortion.
Systematic Review Registration:
http://www.crd.york.ac.uk/PROSPERO , identifier: CRD 42021277869.
A comparative study on the effects of hemp seed oil versus four different UFA-rich seed oils in the diets of laying hens on egg production, egg quality and yolk fatty acids
Authors: Kanbur Gülşah , Göçmen Rabia , Cufadar Yusuf 
Published: September 2022

Abstract
This study compared the effects of hemp seed oil versus four different UFA-rich seed oils in the diet of laying hens on egg production, quality, and fatty acid profile of the yolk. Soybean, sunflower, corn, canola, and hemp seed oils were included in the hens' diets in equal proportions. A total of one hundred and twenty 42-week old White Leghorn hens were placed in five diet groups with 8 replicates. The trial lasted 84 days and data were collected on egg production, quality, and fatty acid profile of the yolk. The data showed that none of the incorporated seed oils affected egg production or quality. However, hemp seed oil altered yolk colour values similarly to canola oil by increasing the L* value of the yolk while decreasing the a* value (P < 0.05). Hemp oil increased the PUFA content in the yolk, similar to soybean, corn, and sunflower oil, but unlike the latter, it also enriched the n-3 fatty acids in the yolk (P < 0.05). In conclusion, hemp seed oil can be safely used in the diet of chickens without having negative effects on egg production and quality like other seed oils. Furthermore, hemp seed oil can improve the desirable fatty acid content in the yolk and has the potential to produce n-3 design eggs.
The composition of Gut microflora of stingless honey bee (Apidae: Tetragonula) from Dharangaon taluka of Jalgaon district
Authors: Nikam Varun B. , Salunkhe Hemant. P. , Chopda Manoj. Z. 
Published: September 2022

Abstract
Stingless bees are the main pollinators in tropical regions because they entirely rely on flowers for nectars and pollen to feed their larvae. They help in pollinating many forests and are valued pollinators in biodiversity. Tetragonula /Trigona is known as the largest genera of stingless bees comprising 32 species worldwide and (meliponini) is by far the largest group of eusocial bees on earth with more than 500 described species and 43 species occurring in the Asian region. In a sterile environment, we surface-sterilized the bees in 75% alcohol for 20 s and then washed them with sterile water. Finally, the entire gut was removed from the abdomen of each bee. The sample was homogenized with 1 ml of Insect saline solution. 16S RNA analysis was performed by the outsourcing service from Rajiv Gandhi Center for Biotechnology, Thiruvananthapuram.The results showed that the gut of stingless bees contained the bacteria of the Priestia genus
LS solving of nonlinear equations by the T-Secant method with super-quadratic convergence
Authors: Berzi Peter 
Published: September 2022

Abstract
A new secant-method based numerical procedure (T-secant method) with super-quadratic convergence (convergence rate 2.618) has been developed for least-squares solving of simultaneous multi-variable nonlinear equations. The basic idea of the procedure is that the original secant equations are modified by a non-uniform scaling transformation “T”, an additional new estimate is determined in each iteration and a completely new set of trial solutions is constructed for the next iteration. The suggested method seems to eliminate the unstable behavior of the traditional method and the efficiency is an order higher than Broyden’s methods in case of the numerical example. The vector-based interpretation and its geometrical representation helps to explain the basic operations. The performance of the new method is demonstrated by the results of numerical tests with a Rosenbrock-type test-function with up to 1000 unknown variables.
Local corneal UVA crosslinking used for corneal ulcer treatment in a child. A clinical case
Authors: Mamakaeva I. R. , Pleskova A. V. , Iomdina E. N. , Katargina L. A. 
Published: September 2022

Purpose: to evaluate the results of corneal ultraviolet (UVA) crosslinking used in the complex treatment of recurrent corneal ulcer in a child. Patient K., 6, was treated in the department of children eye pathology with the diagnosis of corneal ulcer. The case history said the patient was sick for 2 years, periods of remission alternated with exacerbation. Immunological examination revealed sensitization to herpes simplex virus types 1 and 2 (IgG = 3.2 with the norm of < 0.18). The combined treatment included drug therapy and local UVA crosslinking of the cornea (7 procedures per 6 minutes every other day). Optical coherence tomography showed positive changes during treatment: the depth and area of cornea infiltrate became smaller. 1 month after the last procedure, the inflammatory process was stopped and the corneal clarity gradually restored whilst vascular activity became less intense. After 2 months, the infiltrate area became clear throughout. OCT revealed a gradual decrease of the infiltrate thickness and a replacement of the cornea with a transparent tissue.Conclusion. Local corneal UV-crosslinking used as part of the complex treatment of keratitis and corneal ulcers in children is a very promising method for implementation in clinical practice.
Repeated micropulse cyclophotocoagulation in the treatment of refractory glaucoma. A clinical experience
Authors: Ioshin I. E. , Tolchinskay A. I. , Maksimov I. V. , Rakova A. V. 
Published: September 2022

Purpose: to analyze the results of repeated micropulse transscleral cyclophotocoagulation (mTSCPC) in the treatment of refractory glaucoma (RG).Material and methods. We examined 74 patients aged 73.2 ± 6.3 years with developed (13), advanced (48) and terminal (13) stages of refractory glaucoma before and within 15 months after the first mTSCPC (SUPRA 810, Quantel Medical, France) using standard laser parameters — 100 J. According to indications, the repeated mTSCPC was performed for 17 patients. Of these, 4 patients had the second procedure three months after the first procedure, 10 patients — 6 months after it, and 3 patients, 9 months after the first procedure. The repeated mTSCPC was performed with an impact energy higher than the first one — 125 J.Results. After the first procedure, the hypotensive effect was held in 57 patients with RG (77.0 %) up to 15 months of the follow-up. The repeated mTSCPC given to 17 patients made it possible to reduce intraocular pressure (IOP) by 38.5 % for the developed RG stage, by 33.9 % for the advanced stage, and by 21.4 % at the terminal stage (p < 0.05) by 6–12 months of follow-up. The hypotensive effect was held in 13 out of 17 patients by the end of the follow-up.Сonclusion. Single and repeated mTSCPC with laser energies of 100 J and 125 J are effective and safe techniques of RH treatment. Possibly, it is worth revising the basic parameters of the mTSCPC procedure from 100 to 125 J to achieve a longer and at the same time safe hypotensive effect in patients with RG.
The range of clinical manifestations of congenital glaucoma found in people seeking consultation at the Helmholtz National Medical Research Center of Eye Diseases
Authors: Katargina L. A. , Sorokin A. A. , Arestova N. N. , Panova A. Yu. , Kruglova T. B. , Kogoleva L. V. , Sudovskaya T. V. 
Published: September 2022

Purpose: to analyze clinical and functional manifestations and the course of different stages of primary congenital glaucoma (CG) at different times of the disease onset, using the data of admissions to the Department of Eye Pathology in Children of the Helmholtz Research Center of Eye Diseases.Material and methods. 191 patients (320 eyes) with CG, of which 113 were children (191) eyes with primary congenital glaucoma (PCG) aged 1 month to 16 years, underwent standard ophthalmological examination (autorefractometry, visometry, biomicroscopy, ophthalmoscopy), electrophysiological examination (flash VEP, ganzfeld and flicker ERG) and echobiometry (axial eye length measurement).Results. A detailed clinical and functional characteristic of PCG, including structural and functional changes occurring at different stages. Most children with PСG showed advanced stages of the glaucomatous process: in cases where PСG was detected by 1 month of life, the advanced stages claimed 71.1 %, whilst the children diagnosed with PCG between 1 and 12 months of age, the advanced stages were found in 91.2 %. clinical manifestations were found to have variability, not always corresponding to the stages of the disease. In particular, we detected a correlation between disease progression and decreased VEP amplitude (p < 0.05), while no such correlation was found with respet to ERG parameters and VEP latency.Conclusion. Despite the fact that PCG is detected comparative early, the destructive glaucomatous eye damage leads to severe and often irreversible consequences. The timing of CG manifestation is determined by the degree of congenital abnormalities in the eye drainage system that, together with secondary structural changes of eyes (cornea, axial length, retina and ONH) entail a more severe prognosis of PCG in case of an early disease onset. New objective criteria are needed to assess the severity and prognosis of PCG, which is important for the preservation of visual functions, prevention of low vision and blindness.