bluuebunny/crossref_metadata_2025_split huggingface dataset:
New leptons with exotic decays: collider limits and dark matter complementarity
Authors: Guedes Guilherme , Santiago José 
Published: January 2022

Abstract
We describe current and future hadron collider limits on new vector-like leptons with exotic decays. We consider the possibility that, besides standard decays, the new leptons can also decay into a Standard Model charged lepton and a stable particle like a dark photon. To increase their applicability, our results are given in terms of arbitrary branching ratios in the different decay channels. In the case that the dark photon is stable at cosmological scales we discuss the interplay between the dark photon and the vector-like lepton in generating the observed dark matter relic abundance and the complementarity of collider searches and dark matter phenomenology.
Dark matter in three-Higgs-doublet models with S3 symmetry
Authors: Khater W. , Kunčinas A. , Ogreid O. M. , Osland P. , Rebelo M. N. 
Published: January 2022

Abstract
Models with two or more scalar doublets with discrete or global symmetries can have vacua with vanishing vacuum expectation values in the bases where symmetries are imposed. If a suitable symmetry stabilises such vacua, these models may lead to interesting dark matter candidates, provided that the symmetry prevents couplings among the dark matter candidates and the fermions. We analyse three-Higgs-doublet models with an underlying S3 symmetry. These models have many distinct vacua with one or two vanishing vacuum expectation values which can be stabilised by a remnant of the S3 symmetry which survived spontaneous symmetry breaking. We discuss all possible vacua in the context of S3-symmetric three-Higgs-doublet models, allowing also for softly broken S3, and explore one of the vacuum configurations in detail. In the case we explore, only one of the three Higgs doublets is inert. The other two are active, and therefore the active sector, in many aspects, behaves like a two-Higgs-doublet model. The way the fermions couple to the scalar sector is constrained by the S3 symmetry and is such that the flavour structure of the model is solely governed by the VCKM matrix which, in our framework, is not constrained by the S3 symmetry. This is a key requirement for models with minimal flavour violation. In our model there is no CP violation in the scalar sector. We study this model in detail giving the masses and couplings and identifying the range of parameters that are compatible with theoretical and experimental constraints, both from accelerator physics and from astrophysics.
Cognitive performance during adulthood in a rat model of neonatal diffuse white matter injury
Authors: Achterberg E. J. Marijke , van Oldeniel Ralf J. , van Tilborg Erik , Verharen Jeroen P. H. , Nijboer Cora H. , Vanderschuren Louk J. M. J. 
Published: January 2022

Abstract
Rationale
Infants born prematurely risk developing diffuse white matter injury (WMI), which is associated with impaired cognitive functioning and an increased risk of autism spectrum disorder. Recently, our rat model of preterm diffuse WMI induced by combined fetal inflammation and postnatal hypoxia showed impaired motor performance, anxiety-like behaviour and autism-like behaviour in juvenile rats, especially males. Immunohistochemistry showed delayed myelination in the sensory cortex and impaired oligodendrocyte differentiation.

Objective
To assess long-term cognitive deficits in this double-hit rat model of diffuse WMI, animals were screened on impulsivity, attention and cognitive flexibility in adulthood using the 5-choice serial reaction time task (5CSRTT) and a probabilistic reversal learning task, tests that require a proper functioning prefrontal cortex. Thereafter, myelination deficits were evaluated by immunofluorescent staining in adulthood.

Results
Overall, little effect of WMI or sex was found in the cognitive tasks. WMI animals showed subtle differences in performance in the 5CSRTT. Manipulating 5CSRTT parameters resulted in performance patterns previously seen in the literature. Sex differences were found in perseverative responses and omitted trials: female WMI rats seem to be less flexible in the 5CSRTT but not in the reversal learning task. Males collected rewards faster in the probabilistic reversal learning task. These findings are explained by temporally rather than permanently affected myelination and by the absence of extensive injury to prefrontal cortical subregions, confirmed by immunofluorescent staining in both adolescence and adulthood.

Conclusion
This rat model of preterm WMI does not lead to long-term cognitive deficits as observed in prematurely born human infants.
A 3D printable adapter for solid-state fluorescence measurements: the case of an immobilized enzymatic bioreceptor for organophosphate pesticides detection
Authors: Rodrigues Andreia C. M. , Barbieri Maria Vittoria , Chino Marco , Manco Giuseppe , Febbraio Ferdinando 
Published: January 2022

AbstractThe widespread use of pesticides in the last decades and their accumulation into the environment gave rise to major environmental and human health concerns. To address this topic, the scientific community pointed out the need to develop methodologies to detect and measure the presence of pesticides in different matrices. Biosensors have been recently explored as fast, easy, and sensitive methods for direct organophosphate pesticides monitoring. Thus, the present work aimed at designing and testing a 3D printed adapter useful on different equipment, and a membrane support to immobilize the esterase-2 from Alicyclobacillus acidocaldarius (EST2) bioreceptor. The latter is labelled with the IAEDANS, a bright fluorescent probe. EST2 was selected since it shows a high specificity toward paraoxon. Our results showed good stability and replicability, with an increasing linear fluorescent intensity recorded from 15 to 150 pmol of labelled EST2. Linearity of data was also observed when using the immobilized labelled EST2 to detect increasing amounts of paraoxon, with a limit of detection (LOD) of 0.09 pmol. This LOD value reveals the high sensitivity of our membrane support when mounted on the 3D adapter, comparable to modern methods using robotic workstations. Notably, the use of an independent support significantly simplified the manipulation of the membrane during experimental procedures and enabled it to match the specificities of different systems. In sum, this work emphasizes the advantages of using 3D printed accessories adapted to respond to the newest research needs.
Graphical abstract
Arterio-ureteral fistula: a nationwide cross-sectional questionnaire analysis
Authors: Lock Tycho M. T. W. , Kamphorst Kyara , van den Bergh Roderick C. N. , Moll Frans L. , de Vries Jean-Paul P. M. , Lo Rob T. H. , de Kort Gérard A. P. , Bruijnen Rutger C. G. , Dik Pieter , Horenblas Simon , de Kort Laetitia M. O. 
Published: January 2022

Abstract
Purpose
Arterio-ureteral fistula (AUF) is an uncommon diagnosis, but potentially lethal. Although the number of reports has increased over the past two decades, the true incidence and contemporary urologists’ experience and approach in clinical practice remains unknown. This research is conducted to provide insight in the incidence of AUF in The Netherlands, and the applied diagnostic tests and therapeutic approaches in modern practice.

Methods
A nationwide cross-sectional questionnaire analysis was performed by sending a survey to all registered Dutch urologists. Data collection included information on experience with patients with AUF; and their medical history, diagnostics, treatment, and follow-up, and were captured in a standardized template by two independent reviewers. Descriptive statistics were used.

Results
Response rate was 62% and 56 AUFs in 53 patients were reported between 2003 and 2018. The estimated incidence of AUF in The Netherlands in this time period is 3.5 AUFs per year. Hematuria was observed in all patients; 9% intermittent microhematuria, and 91% presenting with, or building up to massive hematuria. For the final diagnosis, angiography was the most efficient modality, confirming diagnosis in 58%. Treatment comprised predominantly endovascular intervention.

Conclusion
The diagnosis AUF should be considered in patients with persistent intermittent or massive hematuria.
The effects of eccentric hamstring exercise training in young female handball players
Authors: Váczi Márk , Fazekas Gábor , Pilissy Tamás , Cselkó Alexandra , Trzaskoma Lukasz , Sebesi Balázs , Tihanyi József 
Published: January 2022

Abstract
Purpose
The multidimensional role of hamstring muscle group strength in athletic performance and injury prevention is well documented, and nordic hamstring exercise (NHE) is a popular method for the development of hamstring strength. Our aim was to examine the EMG characteristics of the eccentric NHE as well as the effects of long-term eccentric NHE training on muscle strength and vertical jump performance in 10- to 11-year-old female handball players.

Methods
Players from the same handball team were randomly assigned to an eccentric NHE training (13 players) or a control group (10 players). Both groups continued their regular handball training routine, but the NHE group performed additional eccentric NHE exercises once or twice a week, with progressively increasing volume, over 20 weeks. To test training effects, countermovement jump (CMJ) height, eccentric hamstring impulse, peak torque, and angle of peak torque were evaluated before, during and after the training period. In the pre-exercise test, EMG activity of the medial and lateral hamstring muscle was also assessed during NHE.

Results
Hamstring activities ranged between 98 and 129%. Lateral hamstring activity was greater than medial only in the right leg during NHE. Eccentric hamstring impulse improved in both legs at 10 weeks in both groups. Then, at 20 weeks, it remained unchanged in the NHE but decreased in controls. A similar adaptation was seen in eccentric hamstring torque, without change in the optimum knee angle. CMJ height improved only in the NHE.

Conclusion
It is concluded that NHE activates the hamstring musculature effectively, and a favourable mechanical adaptation to long-term NHE exercise in girls can be triggered as early as 11 years of age.
The invasive crayfish Faxonius immunis causes the collapse of macroinvertebrate communities in Central European ponds
Authors: Herrmann Alexander , Grabow Karsten , Martens Andreas 
Published: January 2022

AbstractThe invasive crayfish Faxonius immunis is regarded as a threat to amphibians and macroinvertebrates in the Upper Rhine Valley, Germany, eradicating macrophytes and establishing high-density populations in stagnant waters. This study investigates the macroinvertebrate community structure of five conservation ponds south of Karlsruhe, Germany, to identify effects caused by this invasive crayfish. Two of the ponds had a high population density of F. immunis, two were expected to have lower crayfish densities as they had been habitat modified with gravelled water beds as a crayfish management approach, and one pond was known to be free of crayfish but contained fish. The macroinvertebrate communities were analyzed considering their species richness and composition. The relative density of F. immunis within the samples was regarded as a representative indicator for crayfish population density and tested for its influence on the ordination along with habitat composition and abiotic factors using distance-based redundancy analysis. F. immunis was identified as a driving factor of the macroinvertebrate communities of sampled ponds. Additionally, this study indicates that gravelling ground beds as a management method for invasive burrowing crayfish species does not significantly influence the community composition but can minimize indirect effects caused by F. immunis.
Strain Sensor Based on Embedded Fiber Bragg Grating in Thermoplastic Polyurethane Using the 3D Printing Technology for Improved Sensitivity
Authors: Ahmad Harith , Alias Mohamad Ashraff , Ismail Mohammad Faizal , Ismail Nor Najwa , Zaini Muhammad Khairol Annuar , Lim Kok Sing , Brambilla Gilberto , Grattan Kenneth T. V. , Rahman B. M. Azizur 
Published: January 2022

AbstractA new and easy-to-fabricate strain sensor has been developed, based on fiber Bragg grating (FBG) technology embedded into a thermoplastic polyurethane filament using a 3-dimensional (3D) printer. Taking advantage of the flexibility and elastic properties of the thermoplastic polyurethane material, the embedding of the FBG provides durable protection with enhanced flexibility and sensitivity, as compared to the use of a bare FBG. Results of an evaluation of its performance have shown that the FBG sensors embedded in this way can be applied effectively in the measurement of strain, with an average wavelength responsivity of 0.013 5 nm/cm of displacement for tensile strain and −0.014 2 nm/cm for compressive strain, both showing a linearity value of up to 99%. Furthermore, such an embedded FBG-based strain sensor has a sensitivity of ∼1.74 times greater than that of a bare FBG used for strain measurement and is well protected and suitable for in-the-field use. It is also observed that the thermoplastic polyurethane based (TPU-based) FBG strain sensor carries a sensitivity value of ∼2.05 times higher than that of the polylactic acid based (PLA-based) FBG strain sensor proving that TPU material can be made as the material of choice as a “sensing” pad for the FBG.
MacularNet: Towards Fully Automated Attention-Based Deep CNN for Macular Disease Classification
Authors: Mishra Sapna S. , Mandal Bappaditya , Puhan Niladri B. 
Published: January 2022

AbstractIn this work, we propose an attention-based deep convolutional neural network (CNN) model as an assistive computer-aided tool to classify common types of macular diseases: age-related macular degeneration, diabetic macular edema, diabetic retinopathy, choroidal neovascularization, macular hole, and central serous retinopathy from normal macular conditions with the help of scans from optical coherence tomography (OCT) imaging. Our proposed architecture unifies refined deep pre-trained models using transfer learning with limited training data and a deformation-aware attention mechanism encoding crucial morphological variations appearing in the deformation of retinal layers, detachments from the subsequent layers, presence of fluid-filled regions, geographic atrophy, scars, cysts, drusen, to achieve superior macular imaging classification performance. The proposed attention module facilitates the base network to automatically focus on the salient features arising due to the macular structural abnormalities while suppressing the irrelevant (or no cues) regions. The superiority of our proposed method lies in the fact that it does not require any pre-processing steps such as retinal flattening, denoising, and selection of a region of interest making it fully automatic and end-to-end trainable. Additionally, it requires a reduced number of network model parameters while achieving higher diagnostic performance. Extensive experimental results, analysis on four datasets along with the ablation studies show that the proposed architecture achieves state-of-the-art performance.
Impact of Dissolution of Saline‐Alkaline Soils on the Hydrochemistry and Erosion Rates of the Ganga River System
Authors: Chatterjee Jayati , Singh Sunil Kumar 
Published: January 2022

AbstractWe characterize here the saline‐alkaline soils composed of Na2CO3and NaHCO3in the Ganga floodplain and the peninsular basin using various chemical proxies and the isotopic composition of Sr. Abundance of saline‐alkaline soils in the Ganga floodplain and their higher solubility make them an important source of non‐chloride Na and other dissolved ions including Sr to the river waters. Inverse model based source apportionment of dissolved ions indicates ∼26%–71% of Na at the Ganga outflow is influenced by the saline‐alkaline soils; however, in some of the tributaries of the Ganga in the floodplain, for example, in the Gomti, this contribution exceeds 85%. The estimated silicate erosion rate by correcting for the saline‐alkaline soil contribution in the Ganga floodplain (∼5 tons km−2 yr−1) is less than one third of that of the Himalayan headwaters (16 tons km−2 yr−1) emphasizing the important role of physical erosion in controlling the chemical erosion in the mountain catchments compared to higher temperature and residence time in the floodplain. The silicate sourced dissolved fluxes from the floodplains are comparable to those from the Himalaya because of the vast drainage area of the floodplains and peninsular catchment. The findings of this study have direct relevance to studies on the determination of silicate weathering rates of not only the Ganga system, but also of other basins infested by saline‐alkaline soils such as the Columbia, the Colorado, the upper Rio Grande, the Missouri‐Mississippi river system, the Parana river, the Niger, the Nile, and the Orange.
GLOBAL HOSPITALIZATION TRENDS FOR CROHN’S DISEASE AND ULCERATIVE COLITIS: SYSTEMATIC REVIEW WITH TEMPORAL ANALYSES
Authors: Buie Michael , Quan Joshua , Windsor Joseph , Coward Stephanie , Gearry Richard , Hansen Tawnya , King James , Kotze Paulo , Ng Siew , Mak Joyce , Panaccione Remo , Seow Cynthia , Underwood Fox , Kaplan Gilaad 
Published: January 2022

Abstract

INTRODUCTION
The evolving epidemiologic patterns of IBD throughout the world, in conjunction with advances in therapeutic treatments, may influence hospitalization rates of IBD in the 21st century. We performed a systematic review with temporal analysis of hospitalization rates for IBD across the world in the 21st century.

METHODS
We systematically reviewed MedLine and Embase for population-based studies reporting hospitalization rates for IBD, Crohn’s disease (CD), or ulcerative colitis (UC) since 2000. Log-linear models were used to calculate average annual percentage change (AAPC) with associated 95% confidence intervals (CI). Random effects meta-analysis pooled AAPCs stratified by countries in the Western world (i.e. North America, Western Europe, and Oceania) versus newly industrialized countries in Eastern Europe, Asia, Latin America, and Africa. Secondarily, we compared hospitalization rates by primary diagnosis of IBD versus all-cause hospitalizations. QGIS 3.44 was used to create a choropleth map of AAPC and ArcGIS Pro 2.4.1 was used to develop an online, interactive map of global hospitalization trends.

RESULTS
Data were extracted from 87 studies comprising 42 countries. Overall, hospitalization rates were stable in countries of the Western world for IBD (AAPC=−0.25; 95% CI: −0.90, 0.41, n=22), CD (AAPC=2.76; 95% CI: −0.62, 6.15, n=8), and UC (AAPC=1.44; 95% CI: −1.98, 4.86, n=7) (Table 1). However, heterogeneity between countries was observed, for example, hospitalization rates for CD (−0.02%; 95%CI: −0.52, 0.48) and UC (0.40%; 95%CI: −0.81, 1.63) were stable in the USA, but increasing for CD (2.05%; 95%CI: 1.25, 2.84) and UC (1.69%; 95%CI: 0.99, 2.39) in Portugal (Figure 1). CD and UC hospitalization rates in newly industrialized countries increased in Mexico (CD: 5.21%; 95%CI: 3.07, 7.39; UC: 5.96%; 95%CI: 4.30, 7.64), Chile (CD: 6.03%; 95%CI: 5.21, 6.86; UC: 3.78%; 95%CI: 3.43, 4.13), Bahrain (CD: 12.98%; 95%CI: 7.83, 18.38; UC: 7.27%; 95%CI: 2.12, 12.69), and Hong Kong (CD: 8.67%; 95%CI: 5.81, 11.61; UC: 0.14%; 95%CI: −2.21, 2.53), but significantly decreased in Brazil for CD (−3.22%; 95%CI: −5.24, −1.15) and UC (−3.41; 95%CI: −4.63, −2.18) (Figure 1). Studies that defined hospitalization rates as the primary diagnosis of IBD versus all-cause hospitalizations may explain heterogeneity between countries (Table 1).

CONCLUSION
Hospitalization rates for IBD are stabilizing in North America, Europe, and Oceania. In contrast, newly industrialized countries in Asia and Latin America have rapidly rising hospitalization rates, contributing to an increasing burden on global healthcare systems. Future studies should explore clinical and methodological factors that explain heterogeneity between country-specific hospitalization rates.
INTESTINAL EPITHELIAL CELL-SPECIFIC CFTR KNOCKOUT MICE EXHIBIT FECAL MICROBIAL DYSBIOSIS
Authors: Young Sarah , Ericsson Aaron , Woode Rowena , Clarke Lane 
Published: January 2022

Abstract

BACKGROUND
Chronic intestinal inflammation is a poorly understood manifestation of Cystic Fibrosis (CF) disease. Fecal microbial dysbiosis has the potential of inducing intestinal inflammation and has been reported in people with CF as well as CF mouse models. CF mice consuming an osmotic polyethylene glycol (PEG) laxative in drinking water to prevent intestinal obstruction have low levels of intestinal inflammation and low intestinal bacterial loads. In contrast, CF mice consuming a nutritionally complete liquid diet to prevent intestinal impaction exhibit intestinal inflammation and high intestinal bacterial loads (R. C. De Lisle, et al., Am J Physiol 293, G577-G584, 2007) To investigate the development of dysbiosis in a CFTR-deficient intestine, we transitioned adult intestinal epithelial cell-specific knockout and wild-type (WT) mice from life-long consumption of PEG laxative to a nutritionally-complete liquid diet for a two week period before collection of fecal samples.

METHODS
Fecal samples collected from B6.Cg-Tg(Vil1-cre)-Cftrf10/f10 intestinal-specific Cftr knockout mice (iCftr KO) and their WT sex-matched littermates were DNA extracted and prepared for 16S rRNA sequencing and evaluation of the microbiome. Microbial community composition, richness and diversity indices, and relative abundance of bacterial species of interest were evaluated.

RESULTS
16S rRNA sequencing and metagenomic analysis revealed significant differences in microbial composition with intestinal-specific loss of CFTR as compared to WT, as well as a significant decrease in Shannon diversity and Chao-1 richness indices. A significant deficit of taxa was seen in the intestinal-specific CF mice, as compared to WT, which corresponded with a significant increase in bacterial species that potentially serve as provocateurs of intestinal inflammation including Helicobacter typhlonius, Clostridium perfringens, Ruminococcus gnavus, and Tyzerella spp.

CONCLUSIONS
As compared to WT, the transition from PEG laxative to a nutritionally-complete liquid diet resulted in overt differences in the fecal microbiota composition in iCftr KO mice which included enrichment of potential bacterial pathobionts capable of stimulating intestinal inflammation. These studies suggest that the CFTR-deficient intestinal epithelium provides an environment selective for potential bacterial pathobionts. The paradigm of the study may prove useful for investigating the development of dysbiosis and corresponding changes in intestinal mucosal immunity.