bluuebunny/crossref_metadata_2025_split huggingface dataset:
The built environment in Social Media: towards a Biosemiotic Approach
Authors: Bellentani Federico , Arkhipova Daria 
Published: July 2022

AbstractThe paper presents a biosemiotic approach to the study of the built environment, its representations and practices in social media. First, it outlines the main developments that make semiotics hold a significant position in the study of urban space and the built environment. It then goes on to overcome the limitations of the binary opposition paradigm: in particular, nature/culture is reconsidered as a category in which the two terms are in a relation of mutual participation rather than being exclusive to each other. Following this, the paper explores three participatory categories that can be useful for the study of the built environment and its social media representations and practices: (a) life/semiosis, (b) natural environment/built environment, (c) text/practice. Finally, it identifies five main topics representing the interplay between the natural and built environment: the interaction of nature and architecture, urban parks, urban agriculture, digital environmentalism and ecotourism.
Leveraging Systematic Reviews to Explore Disease Burden and Costs of Per- and Polyfluoroalkyl Substance Exposures in the United States
Authors: Obsekov Vladislav , Kahn Linda G. , Trasande Leonardo 
Published: July 2022

AbstractAccelerating evidence confirms the contribution of per- and polyfluoroalkyl substances (PFAS) to disease burden and disability across the lifespan. Given that policy makers raise the high cost of remediation and of substituting PFAS with safer alternatives in consumer products as barriers to confronting adverse health outcomes associated with PFAS exposure, it is important to document the costs of inaction even in the presence of uncertainty. We therefore quantified disease burdens and related economic costs due to legacy PFAS exposures in the US in 2018. We leveraged systematic reviews and used meta-analytic inputs whenever possible, identified previously published exposure–response relationships, and calculated PFOA- and PFOS-attributable increases in 13 conditions. These increments were then applied to census data to determine total annual PFOA- and PFOS-attributable cases of disease, from which we calculated economic costs due to medical care and lost productivity using previously published cost-of-illness data. We identified PFAS-attributable disease costs in the US of $5.52 billion across five primary disease endpoints shown to be associated with PFAS exposure in meta-analyses. This estimate represented the lower bound, with sensitivity analyses revealing as much as $62.6 billion in overall costs. While further work is needed to assess probability of causation and establish with greater certainty effects of the broader category of PFAS, the results confirm further that public health and policy interventions are still necessary to reduce exposure to PFOA and PFOS and their endocrine-disrupting effects. This study demonstrates the large potential economic implications of regulatory inaction.
Oldest known West Gondwanan graptolite: Ovetograptus? sp. (lower Agdzian/lowest Wuliuan; basal Middle Cambrian) of the Franconian Forest, Germany, and review of pre-Furongian graptolithoids
Authors: Geyer Gerd , Landing Ed , Meier Stefan , Höhn Stefan 
Published: July 2022

AbstractThe occurrence of a likely graptolite in lowest Wuliuan strata of the Franconian Forest almost certainly records the oldest known graptolithoid hemichordate in West Gondwana and possibly the oldest graptolite presently known. The fossil is a delicate, erect, apparently unbranched rhabdosome with narrow thecae tentatively assigned to the poorly known genus Ovetograptus of the Dithecodendridae. This report includes an overview of pre-Furongian graptolithoids with slight corrections on the stratigraphic position of earlier reported species.
CC chemokine receptor 7 promotes macrophage recruitment and induces M2-polarization through CC chemokine ligand 19&21 in oral squamous cell carcinoma
Authors: Zhou Wan-Hang , Wang Yao , Yan Cong , Du Wei-Dong , Al-Aroomi Maged Ali , Zheng Li , Lin Shan-Feng , Gao Jia-Xing , Jiang Sheng , Wang Zeng-Xu , Sun Chang-Fu , Liu Fa-Yu 
Published: July 2022

AbstractPurposeThis study aimed to investigate the impact of CC chemokine receptor 7 (CCR7) on the recruitment and polarization of tumor-associated macrophages (TAMs) in oral squamous cell carcinoma (OSCC).MethodsWe analyzed CCR7 expression pattern, clinicopathological significance, and its association with M2 macrophage infiltration in OSCC by bioinformatic methods. Small interfering RNA (siRNA) was utilized to silence CCR7 in OSCC cells. Conditioned media (CM) was harvested from transfected OSCC cells to establish a co-culture model of THP-1 derived macrophages and OSCC cells. Transwell assay and cell adhesion assay were performed to examine the effect of CCR7 on macrophages recruitment and adhesion. Cytoskeleton was labelled by phalloidin to observe macrophage morphological changes. Moreover, phenotypic alteration of macrophages was measured using quantitative real-time PCR (qRT-PCR), flow cytometry, and immunofluorescence (IF) staining. Ultimately, recombinant human CCL19 and CCL21 were added into the medium of THP-1 derived macrophages to explore their effects on polarization in vitro.ResultsIn OSCC patients, the overexpression of CCR7 positively correlated with lymph node metastasis and M2 macrophage infiltration. Macrophage not only exhibited enhanced migration, invasion and adhesion abilities, but also appeared more spindle and branched in vitro when treated with CM from OSCC cells. However, these phenomena were abrogated with knockdown of CCR7. We also discovered that inhibition of CCR7 in OSCC cells suppressed TAMs polarization to an M2 phenotype. In addition, recombinant human CCL19 and CCL21 promoted macrophage M2-polarization in vitro.ConclusionCCR7 in OSCC cells promoted recruitment and M2-polarization of THP-1 derived macrophages in vitro by regulating production of CCL19 and CCL21.
From COVID-19 to Green Recovery with natural capital accounting
Authors: Vardon Michael , Lucas Paul , Bass Steve , Agarwala Matthew , Bassi Andrea M. , Coyle Diane , Dvarskas Anthony , Farrell Catherine A. , Greenfield Oliver , King Steven , Lok Martin , Obst Carl , O’Callaghan Brian , Portela Rosimeiry , Siikamäki Juha 
Published: July 2022

AbstractThe COVID-19 pandemic and related social and economic emergencies induced massive public spending and increased global debt. Economic recovery is now an opportunity to rebuild natural capital alongside financial, physical, social and human capital, for long-term societal benefit. Yet, current decision-making is dominated by economic imperatives and information systems that do not consider society’s dependence on natural capital and the ecosystem services it provides. New international standards for natural capital accounting (NCA) are now available to integrate environmental information into government decision-making. By revealing the effects of policies that influence natural capital, NCA supports identification, implementation and monitoring of Green Recovery pathways, including where environment and economy are most positively interlinked.
Visitors flow management at Uffizi Gallery in Florence, Italy
Authors: Attanasio Alessandro , Maravalle Maurizio , Muccini Henry , Rossi Fabrizio , Scatena Gianluca , Tarquini Francesco 
Published: July 2022

AbstractWe present a data-driven solution to manage visitors’ access at the Uffizi Gallery in Florence, Italy. The goal is to avoid the long lines outside the Museum, improving not only visitors’ experience, but also decency and security in the urban area. The solution implements a queue management system based on two data analytics models, one predictive and one prescriptive, which determine the entry time of each visitor. The system, which requires a minimal hardware and software infrastructure, was on the field from October 2018 to January 2020 during the most crowded visiting days, namely the free access days. First we report on the whole design and implementation process, then we show the solutions effectiveness and discuss the lesson learned.
The Prevalence of Adverse Childhood Experiences Among Children and Adolescents Who Display Harmful Sexual Behaviour: A Review of the Existing Research
Authors: Faure-Walker Dulcie , Hunt Nigel 
Published: July 2022

AbstractThere is no systematic review focusing on the prevalence of adverse childhood experiences (ACEs) among children and adolescents who display harmful sexual behaviour (HSB). This study addresses this gap to further our understanding of the aetiology of HSB among children and adolescents. The full text of 87 articles was retrieved and assessed for eligibility, following which 10 articles were deemed relevant for inclusion in the review. These 10 studies were then subjected to quality assessment, data extraction and synthesis. The present review included only studies that used data pertaining to both males and females, and some studies provided a comparison between males and females. There were higher rates of sexual victimisation among females who display HSB. Additionally, child sexual abuse perpetrated by female caregivers is likely to be higher than most of the existing body of research suggests. The findings of the present review corroborate many of the hypotheses discussed in the introduction, emphasising that children and adolescents who display HSB are more likely to have come from backgrounds of trauma, signaling the importance of multi-agency responses, early intervention and the importance of protective factors.
A cost of ownership analysis of batteries in all-electric and plug-in hybrid vehicles
Authors: Baek Donkyu , Bocca Alberto , Macii Alberto 
Published: July 2022

AbstractThe ever-faster transformation of road vehicles from traditional fuel engines to electric motors, is leading to increasingly widespread research on and development of electric vehicles and related infrastructures. In this context, this article addresses the cost aspect of batteries from the owner’s perspective. Specifically, it proposes an analysis of the optimal usage cost of batteries in order to maximize the benefit-cost ratio and battery replacement intervals. In order to analyze battery degradation, various tests were utilized for both a full-battery electric vehicle (BEV) and a plug-in hybrid electric vehicle (PHEV). The results demonstrate greater wear of the PHEV battery when the vehicle is under charge-sustaining mode, that is, when using the combustion engine, while driving with frequent starts and stops. On the other hand, the degradation costs of the BEV battery are generally close to optimal in every scenario, in which the main parameter affecting battery wear is average daily mileage.
A Public Justification Framework for Healthy Eating Policies and the Problems with Institutionalising it
Authors: Bistagnino Giulia 
Published: July 2022

AbstractIn their book Healthy Eating Policy and Political Philosophy: A Public Reason Approach, Matteo Bonotti and Anne Barnhill defend a conception of public reason centred on the notion of accessibility and advance an ethical toolkit public health policy makers can use to ensure they are reasoning publicly when designing healthy eating policies. Finally, they propose to institutionalise the process of public reasoning informed by their ethics framework by designing certain procedures of consultation and deliberation. This article focuses on their institutionalisation and raises some doubts and concerns by arguing that the procedures designed by Bonotti and Barnhill may be counterproductive to some of their aims, in particular with respect to citizens’ control, epistemic injustice, and the conception of citizens as free and equal.
Influence of the high granularity calorimeter stainless steel absorbers onto the Compact Muon Solenoid inner magnetic field
Authors: Klyukhin Vyacheslav ,   for the CMS Collaboration
Published: July 2022

AbstractThe Compact Muon Solenoid (CMS) detector is a general-purpose experimental setup at the Large Hadron Collider (LHC) at CERN to investigate the production of new particles in the proton-proton collisions at a centre of mass energy 13 TeV. The third run of the data taken is started in April 2022 and will continue till the end of 2025. Then, during a long shutdown time, the existing CMS hadron endcap calorimeter will be replaced with a new high granularity calorimeter (HGCal) designed for the higher LHC luminosity. The HGCal contains the stainless-steel absorber plates with a relative permeability limited by a value of 1.05 from estimation of the electromagnetic forces acting on this slightly magnetic material. To exclude the surprises with possible perturbation of the inner magnetic flux density in the region of the charged particle tracking system, an influence of this additional material onto the quality of the magnetic field inside the inner tracker volume is investigated at this limited value of the permeability of stainless steel. The three-dimensional model of the CMS magnet is used for this purpose. The method of the magnetic field double integrals characterizing the charged particle momentum resolution the first time is applied to the CMS detector and the first time is described in the journal publication. The results obtained with this method are presented in detail and discussed.
Conserved histidine and tyrosine determine spectral responses through the water network in Deinococcus radiodurans phytochrome
Authors: Lehtivuori Heli , Rumfeldt Jessica , Mustalahti Satu , Kurkinen Sami , Takala Heikki 
Published: July 2022

AbstractPhytochromes are red light-sensing photoreceptor proteins that bind a bilin chromophore. Here, we investigate the role of a conserved histidine (H260) and tyrosine (Y263) in the chromophore-binding domain (CBD) of Deinococcus radiodurans phytochrome (DrBphP). Using crystallography, we show that in the H260A variant, the missing imidazole side chain leads to increased water content in the binding pocket. On the other hand, Y263F mutation reduces the water occupancy around the chromophore. Together, these changes in water coordination alter the protonation and spectroscopic properties of the biliverdin. These results pinpoint the importance of this conserved histidine and tyrosine, and the related water network, for the function and applications of phytochromes.
Graphical abstract
Exponential Synchronization of Inertial Complex-Valued Fuzzy Cellular Neural Networks with Time-Varying Delays via Periodically Intermittent Control
Authors: Wang Pan , Li Xuechen , Zhang Tianwei 
Published: July 2022

AbstractThis paper mainly studies the exponential synchronization issue for the inertial complex-valued fuzzy cellular neural networks (ICVFCNNs) with time-varying delays via periodically intermittent control. To achieve exponential synchronization, we use a non-reduced order and non-separation approach, which is a supplement and innovation to the previous method. Based on directly constructing Lyapunov functional and a novel periodically intermittent control scheme, sufficient conditions for achieving the exponential synchronization of the ICVFCNNs are established. Finally, an example is given to illustrate the validity of the obtained results.
In-Between the Lines and Pixels: Cartography’s Transition from Tool of the State to Humanitarian Mapping of Deprived Urban Areas
Authors: Oluoch Isaac , Kuffer Monika , Nagenborg Michael 
Published: July 2022

Abstract
Cartography has been, in its pre-modern and modern production of maps, influential in determining how space and territory is experienced and defined. But advancements in telecommunications and geovisualization software, along with geoinformation systems and geoinformation science (GIS), have transformed cartographic practice from a tool of dominantly state apparatus to a scientific, commercial, and humanitarian enterprise. This is exemplified in the use of remote sensing (RS) techniques to acquire, process, and visualize images of the Earth. In the last decade, RS techniques have increasingly incorporated Artificial Intelligence (e.g., Convolutional Neural Networks) to improve the speed and accuracy of feature extraction and classification in remotely sensed images. This paper will investigate the use of CNNs in the classification of deprived urban areas referred to as “slums” and “informal settlements” in the Global South. Using a postphenomenological methodology, this paper shall analyze the role of classification and use of geoinformation in shaping how deprived urban areas are algorithmically classified. This analysis will reveal that besides the technical opportunities and challenges, attention needs to be given to three ethical areas of concern: how deprived area mapping using AI impacts the agency of communities, how there is a potential lack in the democratization of these RS technologies, and how the privacy and data protection of communities being mapped is endangered.
Building Racial and Gender Equity into a National PrEP Access Program
Authors: Johnson Jeremiah , Radix Asa , Copeland Raniyah , Chacón Guillermo 
Published: July 2022

AbstractTransgender and gender diverse (TGD), Black, and Latinx communities have long borne a disproportionate share of the U.S. HIV epidemic, yet these same key demographics are continually underrepresented in national PrEP prescriptions. Black, Latinx, and TGD individuals are also more likely to be uninsured, meaning that a proposed federal program to cover PrEP for people without insurance could provide significant benefit to potential PrEP users from these populations. However, coverage of PrEP costs alone will not end disparities in uptake. This commentary provides additional context and recommendations to maximize effectiveness of a national PrEP program for TGD, Black, and Latinx populations in the US.
On existence of equilibrium under social coalition structures
Authors: Caskurlu Bugra , Ekici Özgün , Kizilkaya Fatih Erdem 
Published: July 2022

AbstractIn a strategic-form game, a strategy profile is an equilibrium if no viable coalition of agents (or players) benefits (in the Pareto sense) from jointly changing their strategies. Weaker or stronger equilibrium notions can be defined by considering various restrictions on coalition formation. For instance, in a Nash equilibrium, it is assumed that viable coalitions are singletons, and in a super strong equilibrium, it is assumed that every coalition is viable. Restrictions on coalition formation can be justified by communication limitations, coordination problems, or institutional constraints. In this paper, inspired by social structures in various real-life scenarios, we introduce certain restrictions on coalition formation, and on their basis, we introduce a number of equilibrium notions. As an application, we study our equilibrium notions in resource selection games (RSGs), and we present a complete set of existence and nonexistence results for general RSGs and their important special cases.
Incidence and recovery of post-surgical heart block in children following cardiac surgery
Authors: Madani Rohit , Aronoff Elizabeth , Posey Jessica , Basu Mohua , Zinyandu Tawanda , Chai Paul , Whitehill Robert , Maher Kevin O. , Beshish Asaad G. 
Published: July 2022

AbstractBackground:A subset of patients who develop post-surgical heart block have recovery of atrioventricular node function. Factors predicting recovery are not understood. We investigated our centre’s incidence of post-surgical heart block and examine factors associated with recovery of atrioventricular node function.Methods:We conducted a single-centre retrospective study of patients 0 – 21 years who underwent cardiac surgery between January 2010 and December 2019 and experienced post-operative heart block. Data including patient and clinical characteristics and operative variables were collected and analysed.Results:Of 6333 surgical hospitalisations, 128 (2%) patients developed post-operative heart block. Of the 128 patients, 90 (70%) had return of atrioventricular node function, and 38 (30%) had pacemaker placement. Of the 38 patients who underwent pacemaker placement, 6 (15.8%) had recovery of atrioventricular node function noted on long-term follow-up. Median time from onset of heart block to late atrioventricular node recovery was 13 days (Interquartile range: 5 – 117). Patients with single-ventricle physiology (p = 0.04), greater weight (p = 0.03), and shorter cardiopulmonary bypass time (p = 0.015) were more likely to have recovery. The use of post-operative steroids was similar between all groups (p = 0.445). Infectious or wound complications were similar between pacemaker groups (p = 1).Conclusions:Two per cent of patients who underwent congenital cardiac surgery developed post-operative heart block, and 0.6% underwent pacemaker placement. Early recovery of atrioventricular node was associated with greater weight at the time of surgery, single-ventricle physiology, and shorter cardiopulmonary bypass time. Late recovery of atrioventricular node conduction following pacemaker placement occurred in 15.8% of patients.
Evaluation of subclinical atherosclerosis and cardiac functions in children of mothers with gestational diabetes and maternal obesity
Authors: Ekici Avci Melda , Tosun Öykü 
Published: July 2022

AbstractBackground and aims:We aimed to evaluate the effects of maternal obesity or gestational diabetes on body composition, lipid, and glucose metabolism, arterial morphology, and functions in children, and to investigate these effects in terms of cardiometabolic diseases.Methods:The study group was composed of 48 children who had a history of gestational diabetes or maternal obesity, and the control group was composed of 33 children. Echocardiographic assessments were performed. Socio-economic status and education level of mothers were obtained.Results:In the study group, carotid intima-media thickness, epicardial adipose tissue thickness, and arterial stiffness values were found to be significantly higher compared to the control group (p < 0.001, p < 0.001, p = 0.003, respectively), while arterial distensibility and arterial strain values were found to be significantly lower (p = 0.003, p = 0.008, respectively). Among the children who had similar body mass index in both groups, children in the study group had higher carotid intima-media thickness and epicardial adipose tissue thickness values. Arterial stiffness values were significantly reduced (p = 0.028) and arterial distensibility and strain values were significantly increased (p = 0.039, p = 0.033, respectively) in the children whose mothers had gestational diabetes and high socio-economic status. Left ventricular mass and left ventricular end-diastolic internal thickness were found to be significantly increased in the children who had obese and unemployed mothers (p = 0.04, p = 0.03, respectively).Conclusion:Low socio-economic status was found to be associated with increased maternal obesity and gestational diabetes. Poor socio-economic status, poor glycaemic control and being overweight during pregnancy indicate negative cardiometabolic outcomes for children in the long term.