bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute effect of Melon Manis Terengganu peel powder on glycemic response, perceived satiety, and food intake: a randomized, placebo-controlled crossover trial in adults at risk of type 2 diabetes
Authors: Ong Ying Qian , Harith Sakinah , Shahril Mohd Razif , Shahidan Norshazila , Hapidin Hermizi 
Published: August 2022

AbstractBackgroundMelon Manis Terengganu (MMT) peel has a high dietary fiber content, but there is no data examining its health benefits in adults at risk of type 2 diabetes. The objective of the study was to evaluate whether consumption of MMT peel powder improves glycemic response, satiety, and food intake in adults at risk of type 2 diabetes.MethodsAn open-label, randomized, placebo-controlled, crossover design trial was conducted among adults (n = 30, ages 18–59 y) at risk of type 2 diabetes. They consumed Formulation 3 (formulated MMT peel powder) [A] and control (glucose) [B] with study breakfast based on randomly assigned treatment sequences (AB, BA) established by Research Randomizer (www.randomizer.org). Capillary blood glucose and perceived satiety were determined at baseline (0 min), 30, 60, 90 and 120 min, followed by a post-intervention food intake measurement.ResultsThe repeated measures analysis of variance (ANOVA) revealed significant time (F = 84.37,p <  0.001, ηp2 = 0.744), condition (F = 22.89,p <  0.001, ηp2 = 0.441), and time*condition effects (F = 24.40,p <  0.001, ηp2 = 0.457) in blood glucose levels. Respondents (n = 30) who consumed Formulation 3 also had a significantly lower blood glucose 2-hour incremental area under the curve (iAUC) of 134.65 ± 44.51 mmol/L*min and maximum concentration (CMax) of 7.20 (7.10, 8.20) mmol/L with relative reduction of 26.8 and 13.3% respectively, when compared with control (p <  0.001). Besides, significantly greater perceived satiety, lower energy and fat intake as well as higher dietary fiber intake were also observed in the intervention group compared with the placebo group (p <  0.05). There were no marked side effects associated with the ingestion of the test products.ConclusionsShort-term consumption of formulated MMT peel powder may improve glycemic response, increase perceived satiety and reduce food intake in adults at risk of type 2 diabetes with the potential to be utilized as a functional beverage. Medium-to long-term clinical trial is warranted to determine whether taking this formulated MMT peel powder on a daily basis has an influence on health outcomes.Trial registrationClinicalTrials.govIdentifier: NCT05298111. Registered 28/03/2022.
Engaging with patients in research on knowledge translation/implementation science methods: a self study
Authors: MacLeod Martha L. P. , Leese Jenny , Garraway Leana , Oelke Nelly D. , Munro Sarah , Bailey Sacha , Hoens Alison M. , Loo Sunny , Valdovinos Ana , Wick Ursula , Zimmer Peter , Li Linda C. 
Published: August 2022

Abstract
Background
In 2017, the British Columbia (Canada) SUPPORT (SUpport for People and Patient-Oriented Research) Unit created six methods clusters to advance methodologies in patient and public oriented research (POR). The knowledge translation (KT)/implementation science methods cluster identified that although there was guidance about how to involve patients and public members in POR research generally, little was known about how best to involve patients and public members on teams specifically exploring POR KT/implementation science methodologies. The purpose of this self-study was to explore what it means to engage patients and the public in studies of POR methods through the reflections of members of five KT/implementation science teams.

Methods
Informed by a collaborative action research approach, this quality improvement self-study focused on reflection within four KT/implementation science research teams in 2020–2021. The self-study included two rounds of individual interviews with 18 members across four teams. Qualitative data were analyzed using a thematic analysis approach followed by a structured discussion of preliminary findings with the research teams. Subsequently, through two small group discussion sessions, the patients/public members from the teams refined the findings.

Results
Undertaking research on POR KT/implementation science methodologies typically requires teams to work with the uncertainty of exploratory and processual research approaches, make good matches between patients/public members and the team, work intentionally yet flexibly, and be attuned to the external context and its influences on the team. POR methodological research teams need to consider that patients/public members bring their life experiences and world views to the research project. They become researchers in their own right. Individual and team reflection allows teams to become aware of team needs, acknowledge team members’ vulnerabilities, gain greater sensitivity, and enhance communication.

Conclusions
The iterative self-study process provided research team members with opportunities for reflection and new understanding. Working with patients/public team members as co-researchers opens up new ways of understanding important aspects of research methodologies, which may influence future KT/implementation science research approaches.
A resilient adjustment method to weigh pseudorange observation in precise point positioning
Authors: Zhang Qieqie , Zhao Long , Zhou Jianhua 
Published: August 2022

AbstractThe accurate weighting of pseudorange observations is important to improve the convergence time and positioning quality of Precise Point Positioning (PPP). Currently, the weight of a pseudorange observation is mainly determined with empirical stochastic models. However, in a complex environment, due to the inability to adapt for the dynamic changes of the user environment, the empirical stochastic models usually cannot reflect the real error level of pseudorange observations. To address this problem, a resilient adjustment method to weigh pseudorange observations is proposed, which constructs the real-time estimation and inflation model for the variance of pseudorange multipath error and measurement noise to replace the empirical stochastic model to determine the weights of pseudorange observations. A set of static and dynamic Global Positioning System (GPS) test data are used to verify the effectiveness of the proposed method. The test results indicate that the proposed real-time estimation model can provide a better representation of the pseudorange accuracy, and the positioning performance of PPP using the real-time estimation model is better than that with the empirical stochastic model. Compared with the optimal empirical stochastic model, the positioning accuracy of PPP with the real-time estimation model is improved by at least 20%, and the convergence time is reduced by at least 50%.
Teprotumumab and the Evolving Therapeutic Landscape in Thyroid Eye Disease
Authors: Kossler Andrea Lora , Douglas Raymond , Dosiou Chrysoula 
Published: August 2022

AbstractContextThyroid eye disease (TED) is a sight-threatening and debilitating autoimmune condition, with limited therapies available, that often poses diagnostic and therapeutic challenges. In recent years, the treatment landscape has shifted to early intervention with targeted therapy.MethodsA PubMed review of the literature was conducted for the period between 1979 and 2021. Search terms included thyroid eye disease, teprotumumab, targeted therapy, Graves disease, Graves ophthalmopathy, dysthyroid optic neuropathy, and related terms in different combinations. Novel biologic therapies for TED have emerged as alternatives to traditional steroid regimens in recent years. New insights into TED pathophysiology have uncovered the role of the insulin-like growth factor 1 receptor (IGF-1R) and led to the development of teprotumumab, an IGF-1R–inhibiting monoclonal antibody.ResultsRandomized clinical trials demonstrating the efficacy of teprotumumab for TED led to Food and Drug Administration approval. Teprotumumab is gradually replacing immunosuppressive agents as first-line therapy in the United States for active moderate-to-severe TED, while emerging reports also show its use in other stages of the disease. Recent data highlight risk factors for adverse events and screening protocols to maximize patient safety. Personalized therapeutic plans developed through effective partnership between endocrinologists and ophthalmologists aim to enhance the safety and outcomes of TED treatments and improve care for this complex disease.ConclusionTED management is shifting to an era of targeted therapy with multidisciplinary care. Teprotumumab has demonstrated superior efficacy to conventional treatments and has transformed our therapeutic and surgical algorithms. Clinical guidelines and additional studies are needed to further guide and refine therapy.
Future Projections in Thyroid Eye Disease
Authors: Barbesino Giuseppe , Salvi Mario , Freitag Suzanne K 
Published: August 2022

Abstract

Background and Aims
This review aims to summarize current and emerging therapies for treatment of thyroid eye disease (TED), in the light of novel understanding of pathogenetic mechanisms, leading to new treatment options and clinical trials.

Methods
We reviewed and analyzed peer-reviewed literature reporting recent translational studies and clinical trials in the treatment of TED. Searches were made at www.pubmed.gov with keywords “thyroid eye disease,” “Graves’ ophthalmopathy,” “thyroid orbitopathy,” and “Graves’ orbitopathy.”

Results
Surgery is reserved for rehabilitation in chronic TED or for emergent compressive optic neuropathy. Oral and intravenous glucocorticoid therapy has been used for decades with variable efficacy in acute TED, but results may be temporary and side effects significant. Nonsteroidal oral immunosuppressive agents offer modest benefit in TED. Several immunomodulatory monoclonal antibodies, including rituximab and tocilizumab, have shown efficacy for inactivating TED. Recently, teprotumumab, an insulin-like growth factor 1 receptor (IGF-1R) inhibitor, has demonstrated significant improvement in proptosis, clinical activity score, diplopia, and quality of life in patients with active TED, with good tolerability. Newly proposed TED therapies, currently in preclinical and clinical trial phases, include thyroid-stimulating hormone (TSH) receptor inhibitory drugs, RVT-1401, local anti-vascular endothelial growth factor therapy, IGF-1R drugs delivered subcutaneously and orally, and desensitization to the TSH receptor with modified TSH receptor peptides.

Conclusion
New, albeit incomplete, understanding of the molecular mechanisms of TED has led to new promising therapies and offered improved outcomes in TED patients. Their full role and their relationship to classical immune suppression should be clarified over the next few years.
Beyond sound: bimodal acoustic calls used in mate-choice and aggression by red-eyed treefrogs
Authors: Caldwell Michael S. , Britt Kayla A. , Mischke Lilianna C. , Collins Hannah I. 
Published: August 2022

ABSTRACTAirborne sound signals function as key mediators of mate-choice, aggression and other social interactions in a wide range of vertebrate and invertebrate animals. Calling animals produce more than sound, however. When displaying on or near a solid substrate, such as vegetation or soil, they also unavoidably excite substrate vibrations because of the physics of sound production and of acoustic propagation, and these vibrations can propagate to receivers. Despite their near ubiquity, these vibrational signal components have received very little research attention and in vertebrates it is unknown whether they are relevant to mate-choice, an important driver of evolutionary divergence. Here, we show that female red-eyed treefrogs are more than twice as likely to choose a male mating call when airborne sound is paired with its corresponding substrate vibrations. Furthermore, males of the same species are more aggressive towards and display a greater range of aggressive behaviors in response to bimodal (sound and vibration) versus unimodal (sound or vibration alone) calls. In aggressive contexts, at least, air- and substrate-borne signal components function non-redundantly. These results are a clear demonstration that vibrations produced by a calling animal can function together with airborne sound to markedly enhance the function of a signal. If this phenomenon proves widespread, this finding has the potential to substantially influence our understanding of the function and evolution of acoustic signals.
A systematic review assessing the effectiveness of COVID-19 mRNA vaccines in chronic kidney disease (CKD) individuals
Authors: Malik Soniya A. , Modarage Kavindiya , Goggolidou Paraskevi 
Published: August 2022

Background: SARS-CoV-2 is a coronavirus that has rapidly spread across the world with a detrimental effect on the global population. Several reports have highlighted an increased mortality rate and a higher severity of COVID-19 infection in chronic kidney disease (CKD) individuals. Upon the development of various SARS-CoV-2 vaccines, mRNA vaccines including BNT162b2 and mRNA-1273 were deemed safe, with a high efficacy in preventing COVID-19 in the general population. This review investigates whether SARS-CoV-2 mRNA vaccines are as effective in triggering an immune response in Dialysis Patients (DPs) and Kidney Transplant Recipients (KTRs) and if a third dose is required in this population. Methods: A systematic search employing the PRISMA criteria was conducted in several major databases, with the data being extracted from publications for the period January 2021 to May 2022 (PROSPERO: CRD42022338514, June 15, 2022). Results: 80 studies were included in this analysis with a total cohort number of 15,059 participants. Overall, 85.29% (OR = 17.08, 95% CI = 15.84-18.42, I2 = 98%) and 41.06% (OR = 0.52, 95% CI = 0.48-0.5, I2 = 95%) of DPs and KTRs included in this review showed positive seroconversion after two doses of either mRNA vaccine, respectively. A total 76% (OR = 6.53, 95% CI = 5.63-7.5, I2 = 96%) of the cohort given a third dose of an mRNA vaccine demonstrated positive seroconversion, with 61.86% (OR = 2.31, 95% CI = 1.95-2.75 I2 = 95%) of the cohort that was assessed for a cellular response displaying a positive response. Conclusions: This data emphasises a reduced incidence of a positive immune response in DPs and KTRs compared to healthy controls, albeit a better response in DPs than when compared to KTRs alone was observed. A third dose appears to increase the occurrence of an immune response in the overall DP/KTR cohort.
Determinants of adherence to insulin and blood glucose monitoring among adolescents and young adults with type 1 diabetes in Qatar: a qualitative study
Authors: AlBurno Hanan , Schneider Francine , de Vries Hein , Al Mohannadi Dabia , Mercken Liesbeth 
Published: August 2022

Background: Adherence to insulin and blood glucose monitoring (BGM) is insufficient in adolescents and young adults (AYAs) with type 1 diabetes (T1D) worldwide and in Qatar. Little is known about the factors related to being aware of non-adherence and the beliefs related to non-adherence in this group. This qualitative study investigated factors related to awareness of, and beliefs about non-adherence, as well as the existence of specific action plans to combat non-adherence using the I-Change model. Methods: The target group was comprised of 20 Arab AYAs (17–24 years of age) with T1D living in Qatar. Participants were interviewed via semi-structured, face-to-face individual interviews, which were audio-recorded, transcribed verbatim, and analyzed using the Framework Method. Results: Suboptimal adherence to insulin, and particularly to BGM, in AYAs with T1D was identified. Some AYAs reported to have little awareness about the consequences of their non-adherence and how this can adversely affect optimal diabetes management. Participants also associated various disadvantages to adherence (e.g., hypoglycemia, pain, among others) and reported low self-efficacy in being adherent (e.g., when outside home, in a bad mood, among others). Additionally, goal setting and action-planning often appeared to be lacking. Factors facilitating adherence were receiving support from family and healthcare providers, being motivated, and high self-efficacy. Conclusions: Interventions that increase awareness concerning the risks of non-adherence of AYAs with T1D are needed, that increase motivation to adhere by stressing the advantages, creating support and increasing self-efficacy, and that address action planning and goal parameters.
A study protocol to prepare an RBD protein for vaccine against COVID-19
Authors: Jahangir ZMG Sarwar , Marnik Arleta Helena 
Published: August 2022

Background: SARS-CoV-2 pandemic is a global threat to humans and the world’s economy. Effective and safe vaccines against this virus are essential to control and eradicate the pandemic. The currently applied vaccines carry SARS-CoV-2 spike-protein mRNA/cDNA. These vaccines go through several cellular processes in the recipients for producing antigens. On the contrary, the SARS-CoV-2 RBD (receptor binding domain)-protein is an antigen. It will directly stimulate antibody production against SARS-CoV-2. Hence, we propose to produce SARS-CoV-2 RBD-protein as a fast acting, effective and safe vaccine. Methods: We propose to reconstruct a plasmid carrying three types of DNA sequences: RBD cDNA, FP (fusion peptide) DNA and sfGFP(superfolder-green-fluorescent-protein), cDNA creating the RBD-FP-sfGFP DNA within an orf (open-reading-frame). Escherichia coli, C2566H, transformed with the reconstructed plasmid will express RBD-FP-sfGFP fusion protein producing green fluorescent cfu (colony forming unit). The RBD-protein will be separated from the sfGFP using an FP specific enterokinase, and eluted by HIC (hydrophobic-interaction-chromatography), detected with a BioVision-Elisa-Kit, and quantified by spectrophotometry at UV280nm and immune simulation will be carried out using C57BL mice. Results: The plasmid reconstruct will carry ampr (ampicillin-resistant) gene as a selective marker and a T7 promoter controlling the expression of RBD-FP-sfGFP fusion protein. The transformed Escherichia coli will efficiently express the RBD-FP-sfGFP fusion protein. The highly efficient sfGFP fused within the RBD-FP-sfGFP will produce green fluorescent cfu. The RBD-FP-sfGFP protein extract from the green cfu, digested by enterokinase and separated by the HIC will produce pure immunoreactive RBD protein. Conclusion: A positive BioVision-ELISA test detects <10 pg RBD protein/ml of the sample. A larger sample of the purified RBD protein can be used as a vaccine following a standard formulation and safety protocols. Once administered, the RBD protein will stimulate antibody production against the SARS-CoV-2 virus. The RBD protein has no potential to recombine with human genome.
An Alternating Method for Cardinality-Constrained Optimization: A Computational Study for the Best Subset Selection and Sparse Portfolio Problems
Authors: Moreira Costa Carina , Kreber Dennis , Schmidt Martin 
Published: August 2022

Cardinality-constrained optimization problems are notoriously hard to solve in both theory and practice. However, as famous examples, such as the sparse portfolio optimization and best subset selection problems, show, this class is extremely important in real-world applications. In this paper, we apply a penalty alternating direction method to these problems. The key idea is to split the problem along its discrete-continuous structure to obtain two subproblems that are much easier to solve than the original problem. In addition, the coupling between these subproblems is achieved via a classic penalty framework. The method can be seen as a primal heuristic for which convergence results are readily available from the literature. In our extensive computational study, we first show that the method is competitive to a commercial mixed-integer program solver for the portfolio optimization problem. On these instances, we also test a variant of our approach that uses a perspective reformulation of the problem. Regarding the best subset selection problem, it turns out that our method significantly outperforms commercial solvers and it is at least competitive to state-of-the-art methods from the literature. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms–Discrete. Funding: The first author thanks the Deutsche Forschungsgemeinschaft (DFG) for its support within “Algorithmic Optimization” [Grant RTG 2126]. The third author thanks the DFG for its support within project A05 and B08 in the “Sonderforschungsbereich/Transregio 154 Mathematical Modeling, Simulation and Optimization using the Example of Gas Networks.” Supplemental Material: The supplementary material is available at https://doi.org/10.1287/ijoc.2022.1211 .
GANGGUAN PSIKOGENIK LATAH GARY ISKAK: KAJIAN PSIKOLINGUISTIK
Authors: Nuril Phasa Hidayah 
Published: August 2022

This research is motivated by the stigma of talkativeness suffered by women, people with low education, and belonging to the lower economic class category. The research entitled "Psychogenic Disorder of Talkative Gary Iskak (Psycholinguistic Study)" aims to describe the talkative and the background of talkative sufferers towards artist Gary Iskak. The theory used in this research is the talkative theory of Abdul Chaer and Soenjono Darjowidjodjo with a psycholinguistic approach. The data collection method used is the referential method with the note-taking technique. In contrast, the data analysis method is the referential method with the determining determinants or the PUP technique. The results found in this study are that there are four general reaction types: Ekolalia, Ekopraxia, Auto Ekolalia, and Automatic Obedience. Then the two types of talkative reactions that are not included in the four categories are a mixture of Ekolalia and Ekopraxia talkative and the impact of voice talk. In addition to the type of talkativeness, it was also found that the factors causing the talkativeness experienced by Gary Iskak when he was in several events found four causes of talkativeness. Among the four, the most frequent cause of talkativeness is being surprised by other people's movements.
PCformer: an MVI recognition method via classification of the MVI boundary according to histopathological images of liver cancer
Authors: Sun Lin , Sun Zhanquan , Wang Chaoli , Cheng Shuqun , Wang Kang , Huang Min 
Published: August 2022

Liver cancer is one of the most common cancers leading to death in the world. Microvascular invasion (MVI) is a principal reason for the poor long-term survival rate after liver cancer surgery. Early detection and treatment are very important for improving the survival rate. Manual examination of MVI based on histopathological images is very inefficient and time consuming. MVI automatic diagnosis based on deep learning methods can effectively deal with this problem, reduce examination time, and improve detection efficiency. In recent years, deep learning-based methods have been widely used in histopathological image analysis because of their impressive performance. However, it is very challenging to identify MVI directly using deep learning methods, especially under the interference of hepatocellular carcinoma (HCC) because there is no obvious difference in the histopathological level between HCC and MVI. To cope with this problem, we adopt a method of classifying the MVI boundary to avoid interference from HCC. Nonetheless, due to the specificity of the histopathological tissue structure with the MVI boundary, the effect of transfer learning using the existing models is not obvious. Therefore, in this paper, according to the features of the MVI boundary histopathological tissue structure, we propose a new classification model, i.e., the PCformer, which combines the convolutional neural network (CNN) method with a visual transformer and improves the recognition performance of the MVI boundary histopathological image. Experimental results show that our method has better performance than other models based on a CNN or a transformer.