bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal changes in spike IgG levels after two doses of BNT162b2 vaccine in Japanese healthcare workers: Do spike IgG levels at 3 months predict levels 6 or 8 months after vaccination?
Authors: Takeuchi Masaaki , Esaki Akina , Higa Yukie , Nakazono Akemi 
Published: June 2022

Background
Accurate timing of BNT162b2 boosters to prevent breakthrough infections of coronavirus disease 2019 (COVID-19) requires reliable estimates of immune status. We hypothesized that spike IgG levels at 3 months after two doses of the BNT162b2 vaccine might predict subsequent spike IgG levels.

Methods and results
Spike IgG levels were tested at 3, 6, and 8 months after the second dose of the BNT162b2 vaccine in 251 Japanese health care workers (median age: 39 years, female: 187).
The median level of spike IgG was 2,882 AU/mL at 3 months. This decreased to 875 AU/mL at 6 months and 579 AU/mL at 8 months. There were good correlations of log-transformed spike IgG levels between 3 and 6 months (r = 0.86) and between 3 and 8 months (r = 0.82). The correlation further improved after excluding three subjects who had possible COVID-19 infections (r = 0.91, r = 0.86). Log-transformed spike IgG levels at 6 or 8 months yields the following equation:
log spike IgG at 6 (8) months = 0.92 (0.86) X log spike IgG at 3 months– 0.23 (0.18). Predicted spike IgG at 6 months of ≥ 300 or < 300 AU/mL had 98% sensitivity, 47% specificity, and 94% accuracy for discriminating subjects whose actual spike IgG titers at 6 months were above or below 300 AU/mL. Corresponding values of predicted spike IgG at 8 months were 97%, 70%, and 93%, respectively.

Conclusions
We conclude that predictive formulae using spike IgG levels at 3 months after two-dose vaccination with BNT162b2 reliably estimate subsequent spike IgG levels up to 8 months and provide useful information in terms of vaccination booster timing.
Impact of COVID-19 on the mental health of public university hospital workers in Brazil: A cohort-based analysis of 32,691 workers
Authors: Barros-Areal Adriana Ferreira , Albuquerque Cleandro Pires , Silva Nayane Miranda , Pinho Rebeca da Nóbrega Lucena , Oliveira Andrea Pedrosa Ribeiro Alves , da Silva Dayde Lane Mendonça , Gomes Ciro Martins , de Oliveira Fernando Araujo Rodrigues , Kurizky Patrícia Shu , Reis Ana Paula Monteiro Gomides , Talma Ferreira Luciano , de Amorim Rivadávio Fernandes Batista , Lima Marta Pinheiro , Besch Claudia Siqueira , Gatto Giuseppe Cesare , Costa Thais Ferreira , da Silva Everton Nunes , Schulte Heidi Luise , Espindola Laila Salmen , da Mota Licia Maria Henrique 
Published: June 2022

Background
In early 2020, the COVID-19 pandemic paralyzed the world and exposed the fragility of health systems in the face of mass illness. Health professionals became protagonists, fulfilling their mission at the risk of physical and mental illness. The study aimed to evaluate absenteeism indirectly related to SARS-CoV-2 infection in a large population of health care professionals.

Methods
An observational longitudinal repeated measures study was performed, including workers linked to 40 public university hospitals in Brazil. All causes of absenteeism were analyzed, focusing on those not directly attributed to COVID-19. Results for the same population were compared over two equivalent time intervals: prepandemic and during the pandemic.

Findings
A total of 32,691 workers were included in the study, with health professionals comprising 82.5% of the sample. Comparison of the periods before and during the pandemic showed a 26.6% reduction in work absence for all causes, except for COVID-19 and mental health-related absence. Concerning work absence related to mental health, the odds ratio was 39.0% higher during the pandemic. At the onset of the pandemic, there was an increase in absenteeism (all causes), followed by a progressive reduction until the end of the observation period.

Interpretation
Work absence related to mental illness among health care professionals increased during the COVID-19 pandemic, highlighting the need for health care managers to prioritize and implement support strategies to minimize absenteeism.
Clinical evaluation of the Diagnostic Analyzer for Selective Hybridization (DASH): A point-of-care PCR test for rapid detection of SARS-CoV-2 infection
Authors: Achenbach Chad J. , Caputo Matthew , Hawkins Claudia , Balmert Lauren C. , Qi Chao , Odorisio Joseph , Dembele Etienne , Jackson Alema , Abbas Hiba , Frediani Jennifer K. , Levy Joshua M. , Rebolledo Paulina A. , Kempker Russell R. , Esper Annette M. , Lam Wilbur A. , Martin Greg S. , Murphy Robert L. 
Published: June 2022

Background
An ideal test for COVID-19 would combine the sensitivity of laboratory-based PCR with the speed and ease of use of point-of-care (POC) or home-based rapid antigen testing. We evaluated clinical performance of the Diagnostic Analyzer for Selective Hybridization (DASH) SARS-CoV-2 POC rapid PCR test.

Methods
We conducted a cross-sectional study of adults with and without symptoms of COVID-19 at four clinical sites where we collected two bilateral anterior nasal swabs and information on COVID-19 symptoms, vaccination, and exposure. One swab was tested with the DASH SARS-CoV-2 POC PCR and the second in a central laboratory using Cepheid Xpert Xpress SARS-CoV-2 PCR. We assessed test concordance and calculated sensitivity, specificity, negative and positive predictive values using Xpert as the “gold standard”.

Results
We enrolled 315 and analyzed 313 participants with median age 42 years; 65% were female, 62% symptomatic, 75% had received ≥2 doses of mRNA COVID-19 vaccine, and 16% currently SARS-CoV-2 positive. There were concordant results for 307 tests indicating an overall agreement for DASH of 0.98 [95% CI 0.96, 0.99] compared to Xpert. DASH performed at 0.96 [95% CI 0.86, 1.00] sensitivity and 0.98 [95% CI 0.96, 1.00] specificity, with a positive predictive value of 0.85 [95% CI 0.73, 0.96] and negative predictive value of 0.996 [95% CI 0.99, 1.00]. The six discordant tests between DASH and Xpert all had high Ct values (>30) on the respective positive assay. DASH and Xpert Ct values were highly correlated (R = 0.89 [95% CI 0.81, 0.94]).

Conclusions
DASH POC SARS-CoV-2 PCR was accurate, easy to use, and provided fast results (approximately 15 minutes) in real-life clinical settings with an overall performance similar to an EUA-approved laboratory-based PCR.
Death and invasive mechanical ventilation risk in hospitalized COVID-19 patients treated with anti-SARS-CoV-2 monoclonal antibodies and/or antiviral agents: A systematic review and network meta-analysis protocol
Authors: Saha Sumanta 
Published: June 2022

Background
The ongoing COVID-19 pandemic has claimed >4 million lives globally, and these deaths often occurred in hospitalized patients with comorbidities. Therefore, the proposed review aims to distinguish the inpatient mortality and invasive mechanical ventilation risk in COVID-19 patients treated with the anti-SARS-CoV-2 monoclonal antibodies and/or the antiviral agents.

Methods
A search in PubMed, Embase, and Scopus will ensue for the publications on randomized controlled trials testing the above, irrespective of the publication date or geographic boundary. Risk of bias assessment of the studies included in the review will occur using the Cochrane risk of bias tool for randomized trials (RoB 2). Frequentist method network meta-analyses (NMA) will compare each outcome’s risk across both types of anti-SARS-CoV-2 agents in one model and each in separate models. Additional NMA models will compare these in COVID-19 patients who were severely or critically ill, immunocompromised, admitted to the intensive care unit, diagnosed by nucleic acid amplification test, not treated with steroids, <18 years old, and at risk of infection due to variants of concern. The plan of excluding non-hospitalized patients from the proposed review is to minimize intransitivity risk. The acceptance of the network consistency assumption will transpire if the local and overall inconsistency assessment indicates no inconsistency. For each NMA model, the effect sizes (risk ratio) and their 95% confidence intervals will get reported in league tables. The best intervention prediction and quality of evidence grading will happen using the surface under the cumulative ranking curve values and the Grading of Recommendations Assessment, Development and Evaluation-based Confidence in Network Meta-Analysis approach, respectively. Sensitivity analysis will repeat the preliminary NMA while excluding the trials at high risk of bias. The Stata statistical software (v16) will be used for analysis. The statistical significance will get determined at p<0.05 and 95% confidence interval.

Trial registration
PROSPERO Registration No: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021277663.
Pemanfaatan Enzim Bromelin dari Tepung Nanas (Ananas comosus L. Merr) untuk Menurunkan Kadar Kafein Kopi pada Proses Pembuatan Sirup Kopi
Authors: Hapsari Azhara Rumba , Broto R.TD Wisnu , Apriyanti Eny 
Published: June 2022

Penelitian ini bertujuan untuk melihat pengaruh pemakaian tepung nanas dengan waktu ekstraksi, sehingga dapat menurunkan kadar kafein kopi arabica dengan menggunakan tepung nanas yang mengandung enzim bromelin terhadap penurunan kadar kafein pada pembuatan sirup kopi. Metode yang digunakan adalah ekstraksi. Variabel tetap pada percobaan ini yaitu berat bubuk kopi, variabel bebas untuk percobaan yaitu variasi waktu, massa dan suhu pemasakan kopi sedangkan variabel terikat adalah kondisi kadar kafein. Hasil dari penelitian ini adalah analisa yang dilakukan yaitu analisa kadar kafein dan analisa gula. Kadar kafein diperoleh hasil pada waktu 3 jam suhu 50°C dan massa 28 gram merupakan hasil terbaik penurunan kafein yang menghasilkan kadar kafein 1,48 %, sedangkan untuk kadar gula diperoleh 48,77%. Hal ini dikarenakan massa tepung nanas dan waktu ekstraksi yang lama sehingga enzim bromelin dari tepung nanas dapat terekstrak dan dapat menurunkan kadar kafein. This study aims to see the effect of using pineapple flour with extraction time so that it can reduce the caffeine content of Arabica coffee using pineapple flour containing the enzyme bromelain on the reduction of caffeine levels in the manufacture of coffee syrup. The method used is extraction. The fixed variable in this experiment is the weight of the powder coffee, the independent variable for the experiment is the variation of time, mass, and temperature of coffee cooking, while the dependent variable is the condition of caffeine content and sugar analysis. Caffeine content was obtained at a time of 3 hours at a temperature of 50°C and a mass of 28 grams wes the best results for decreasing caffeine which resulted in a caffeine content of 1.48% while for a sugar content of 48,77% it was obtained. This is due to the mass of pineapple flour and the long extraction time so that the bromelain enzyme from pineapple flour can be extracted and can reduce caffeine levels.
The State of the UBI Debate: Mapping the Arguments for and against UBI
Authors: Afscharian Dominic , Muliavka Viktoriia , Ostrowski Marius S. , Siegel Lukáš 
Published: June 2022

Abstract
This article provides a map of the UBI debate, structured into the main themes that guide and group the arguments on both sides. It finds that UBI’s supporters and opponents both draw on core principles of justice and freedom, focusing on need and poverty, discrimination and inequality, growth, social opportunity, individuality, and self-development. From an economic perspective, they both appeal to business concerns about efficiency, risk, flexibility, and consumption, as well as labour interests on work fulfilment, working conditions, remuneration, and bargaining. Likewise, they focus on political questions around welfare state reforms, redistribution, taxation and funding sources, democratic citizenship, and the prospects for cross-party policy coalitions. By providing an overview of the thematic pillars of the UBI debate, this article helps researchers and activists locate and orient themselves within the wider spectrum of opinion on UBI.
Online comprehension of conditionals in context: A self-paced reading study on wenn (‘if’) versus nur wenn (‘only if’) in German
Authors: Barthel Mathias , Tomasello Rosario , Liu Mingya 
Published: June 2022

Abstract
Comprehending conditional statements is fundamental for hypothetical reasoning about situations. However, the online comprehension of conditional statements containing different conditional connectives is still debated. We report two self-paced reading experiments on German conditionals presenting the conditional connectives wenn (‘if’) and nur wenn (‘only if’) in identical discourse contexts. In Experiment 1, participants read a conditional sentence followed by the confirmed antecedent p and the confirmed or negated consequent q. The final, critical sentence was presented word by word and contained a positive or negative quantifier (ein/kein ‘one/no’). Reading times of the two quantifiers did not differ between the two conditional connectives. In Experiment 2, presenting a negated antecedent, reading times for the critical positive quantifier (ein) did not differ between conditional connectives, while reading times for the negative quantifier (kein) were shorter for nur wenn than for wenn. The results show that comprehenders form distinct predictions about discourse continuations due to differences in the lexical semantics of the tested conditional connectives, shedding light on the role of conditional connectives in the online interpretation of conditionals in general.
A review of online communication research in Hungary
Authors: Háló Gergő 
Published: June 2022

Abstract
Ever since the mid-nineties, Internet-related communication research has been a growing field in Hungary. Notwithstanding, scholars have so far failed to deliver a systematic overview regarding the historical and topical trends defining the field. To mend this gap, we provide a systematic literature review concerning the main trends and developments of Hungarian online media research as indicated by the most influential journals of the field between 1995 and 2021. Given its historical legacy, Hungary serves as an indicative case study from the socialist and post-socialist Central and Eastern European region, where following the repressive political regime of the Soviet Union, the development of social scientific fields was rendered virtually impossible for decades. In this study, the major research traditions of the field – new media and the Internet; information society; inequalities and the digital divide; education and digital literacy; e-governance; social media; video games; Big Data; algorithms and artificial intelligence – as well as their historical development are assessed. Furthermore, we formulate reflections regarding the results with a high emphasis on current internationalization processes in the region, as well as the prospects of Hungarian communication research within the context of these changes and of the historical-cultural legacies of the country.
Do We Finally Know What the Neolithic Is?
Authors: Nowak Marek 
Published: June 2022

Abstract
Over 20 years ago, an inspiring text by Lech Czerniak (The Neolithic – What’s That?) on understanding the concept of the Neolithic was published. For the present author, the Lech Czerniak’s discourse on the Neolithic was for many years and, to a large extent still is, a conceptual basis for understanding and presenting this issue. This contribution is an examination of the current relevance of Lech Czerniak’s theses. Furthermore, starting from this basis, a subjective attempt will be made to put the topic in some order, since a lack of clarity as to what the Neolithic is and what is not hampers and complicates research activities. Particularly, perhaps a fundamental issue will be assessed whether the concept of Neolithic in any measure reflects the past reality or reflects only our perceptions of that past. Conclusions resulted of the argumentation assume that there were indeed different and real Neolithics in the past. However, these Neolithics had a common denominator, in the form of “new” socio-organizational, ideological, mental, and consequently also meaning structures. They were a prerequisite for the existence of the Neolithic formation. Situations that can be labelled as the Neolithic are reflected archaeologically by the predominance of elements of the “Neolithic package” within a given sector of the cultural system.
Households and Hamlets of the Brześć Kujawski Group
Authors: Bogucki Peter , Grygiel Ryszard 
Published: June 2022

Abstract
Over several decades, we have written extensively about the household as a fundamental organizational unit of the Neolithic society. Starting from our definition of the household cluster at Brześć Kujawski 3 and the detailed analysis of household activities at House 56 at Brześć Kujawski 4, we continue to consider the household as the locus of decision-making and resource allocation even as our thinking has evolved over the intervening years. At the same time, Neolithic households functioned within local concentrations of settlement in which they interacted with other such units. We characterize such local social entities as “hamlets,” adapting the definition used by the anthropologist Frank Cancian to refer to institutionalized alliances of domestic groups in which affiliation is demonstrated through residential proximity. We have studied two such hamlets of the Brześć Kujawski Group: the Osłonki-Miechowice-Konary hamlet and the Smętowo hamlet consisting of Brześć Kujawski and Pikutkowo. We characterize these hamlets to show how they extend our original conception of household-based societies to develop a robust understanding of local Neolithic communities.
An analysis of the evolution of Chinese cities in global scientific collaboration networks
Authors: Cao Zhan , Derudder Ben , Dai Liang , Peng Zhenwei 
Published: June 2022

Abstract
This paper examines the emergence of China – now the world’s largest source of scientific publications – in global science from the perspective of the connectivity of its major cities in interurban scientific collaboration networks. We construct collaboration networks between 526 major cities (including 44 Chinese cities) for 2002–2006 and 2014–2018 based on co-publication data drawn from the Web of Science. Both datasets are analyzed using a combination of different centrality measures, which in turn allows assessing the shifting geographies of global science in general and the shifting position of Chinese cities therein in particular. The results show that: (1) on a global scale, the bipolar dominance of Europe and North America has waned in light of the rise of Asia-Pacific and especially China. Most Chinese cities have made significant gains in different centrality measures, albeit that only a handful of cities qualify as world-leading scientific centers. (2) The rise in connectivity of Chinese cities is therefore geographically uneven, as cities along the East Coast and the Yangtze River corridor have become markedly more prominent than cities in other parts of China. The uneven trajectories of Chinese cities can be traced back to changing institutional, economic, and geopolitical contexts. (3) Evolution in the global scientific collaboration network exhibits strong ‘Matthew Effects’, which can be attributed to the path-dependent nature of knowledge production and preferential attachment processes in scientific collaboration.
Optoception: Perception of Optogenetic Brain Perturbations
Authors: Luis-Islas Jorge , Luna Monica , Floran Benjamin , Gutierrez Ranier 
Published: June 2022

AbstractHow do animals experience brain manipulations? Optogenetics has allowed us to manipulate selectively and interrogate neural circuits underlying brain function in health and disease. However, little is known about whether mice can detect and learn from arbitrary optogenetic perturbations from a wide range of brain regions to guide behavior. To address this issue, mice were trained to report optogenetic brain perturbations to obtain rewards and avoid punishments. Here, we found that mice can perceive optogenetic manipulations regardless of the perturbed brain area, rewarding effects, or the stimulation of glutamatergic, GABAergic, and dopaminergic cell types. We named this phenomenon optoception, a perceptible signal internally generated from perturbing the brain, as occurs with interoception. Using optoception, mice can learn to execute two different sets of instructions based on the laser frequency. Importantly, optoception can occur either activating or silencing a single cell type. Moreover, stimulation of two brain regions in a single mouse uncovered that the optoception induced by one brain region does not necessarily transfer to a second not previously stimulated area, suggesting a different sensation is experienced from each site. After learning, they can indistinctly use randomly interleaved perturbations from both brain regions to guide behavior. Collectively taken, our findings revealed that mice’s brains could “monitor” perturbations of their self-activity, albeit indirectly, perhaps via interoception or as a discriminative stimulus, opening a new way to introduce information to the brain and control brain-computer interfaces.
Living Too Long
Authors: Redmond Matthew 
Published: June 2022

Matthew Redmond, “Living Too Long: Republican Time in Cooper’s Leatherstocking Novels” (pp. 29–55)
This essay first suggests that antebellum America’s cultural imagination was organized around patterns of generational succession unfolding across what I call “republican time,” and then explores the ways that James Fenimore Cooper’s Leatherstocking novels cross-examine and destabilize that pattern. Reading The Pioneers (1823), The Last of the Mohicans (1826), and The Prairie (1827) through the dual lenses of biopolitical criticism and temporality studies, I treat Natty Bumppo, with his stubborn refusal to die or even fully subside into the background of American life, as a friction against the machine of republican time and the idea of steady national progress it implies. With his peculiar perspective on national events, manifesting in a singular use of grammar, Natty’s character opens to Cooper’s readers certain alternative approaches to being in American time. Cooper’s writings thus demonstrate some of the ways that nineteenth-century American historical fiction, far from uncritically celebrating the forces of U.S. expansionism and imperialism, delivers an incisive critique of them.