bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expanding the limits of nephron‐sparing surgery: Surgical technique and mid‐term outcomes of purely off‐clamp robotic partial nephrectomy for totally endophytic renal tumors
Authors: Tuderti Gabriele , Brassetti Aldo , Mastroianni Riccardo , Misuraca Leonardo , Bove Alfredo , Anceschi Umberto , Ferriero Mariaconsiglia , Guaglianone Salvatore , Gallucci Michele , Simone Giuseppe 
Published: January 2022

ObjectivesTo report surgical technique, perioperative, oncological, and mid‐term functional outcomes in a single‐center purely off‐clamp robotic partial nephrectomy series for totally endophytic masses.MethodsA retrospective analysis of a prospectively collected, institutional review board‐approved renal cancer database was carried out to include patients with a totally endophytic renal tumor treated with off‐clamp robotic partial nephrectomy between January 2013 and December 2020 at our center. Our database was queried to identify cases that had been assigned 3 points for the “E” domain of the R.E.N.A.L. nephrometry score and 3 points for the “exophytic rate” domain of the PADUA (Preoperative Aspects and Dimensions Used for an Anatomical) nephrometry score. Preoperative indocyanine green renal mass marking was performed in 33 patients, in whom the tumor was vascularized by a specific feeding artery. Surgical steps, perioperative, oncological and functional data were reported.ResultsFifty‐six consecutive patients with totally endophytic renal masses were treated. The median tumor diameter was 3 cm, and median PADUA and R.E.N.A.L. scores were both 10. The median operative time was 82 min. Low‐grade Clavien complications occurred in two patients (3.6%) and high‐grade Clavien complications were observed in four patients (7.1%). Positive surgical margins were detected in one patient; 2‐year recurrence‐free, cancer‐specific, and overall survival rates were 100%, 100%, and 98.2%, respectively. At a median follow‐up of 24 months, new onset of chronic kidney disease stage 3b occurred in one patient. At last follow‐up, the median estimated glomerular filtration rate was 77 mL/min, with a median estimated glomerular filtration rate percent decrease of 5.5%. Trifecta was achieved in 91% of patients.ConclusionsPurely off‐clamp robotic partial nephrectomy is a feasible and safe surgical approach, even in totally endophytic renal tumors, providing a favorable perioperative complications rate, excellent oncological outcomes, and negligible impact on renal function at mid‐term follow‐up. Indocyanine green preoperative marking of endophytic renal tumors represents a useful tool for rapid intraoperative identification of the mass, real‐time control of resection margins, and a more precise dissection.
Sexual dysfunction in people treated with long‐acting injectable antipsychotics in monotherapy or polypharmacy: a naturalistic study
Authors: Martínez‐Giner Gema , Giménez‐De Llano Elisa , Romero‐Rubio Dolores , Abad‐Pérez María José , Sánchez‐Martínez Vanessa 
Published: January 2022

ABSTRACTSexual dysfunction, psychosis, and antipsychotics are known to be related, but the precise association between them is still unknown. Most evidence about the prevalence of sexual dysfunction in people treated with antipsychotic drugs comes from studies with restrictive samples. That is why our main objective was to determine the prevalence of sexual dysfunction in a real‐life sample of outpatients treated with antipsychotics, considering gender. A cross‐sectional naturalistic study was developed, including people treated with long‐acting injectable antipsychotics, with or without other psychotropic drugs. Participants were interviewed to assess sexual satisfaction through a Likert scale (0 to 10) and the presence of sexual dysfunction (the Psychotropic‐Related Sexual Dysfunction Questionnaire, PRSexDQ‐SALSEX). The participants also had a blood test to determine prolactin (men and women) and testosterone levels (men only). A total of 131 people participated in the study (90 men and 41 women). Some extent of sexual dysfunction was found in 62.2% of men and 51.2% of women. The most frequent sexual dysfunction symptom for both genders was the loss of libido (45%). Hyperprolactinemia was present in 56% of men and 61% of women. The presence of sexual dysfunction was associated with higher doses of antipsychotics, hyperprolactinemia, and smoking in men and with smoking and hyperprolactinemia in postmenopausal women. This study provides real‐life evidence of sexual dysfunction and hyperprolactinemia in persons treated with long‐acting injectable antipsychotics segregated by gender. The high rates of sexual dysfunction and hyperprolactinemia detected corroborate the need to consider these aspects in clinical practice.
Impact of respiratory syncytial virus disease on quality of life in adults aged ≥50 years: A qualitative patient experience cross‐sectional study
Authors: Curran Desmond , Cabrera Eliazar Sabater , Bracke Benjamin , Raymond Kimberly , Foster April , Umanzor Cindy , Goulet Philibert , Powers John H. 
Published: January 2022

AbstractBackgroundInformation about the impact of respiratory syncytial virus (RSV) on quality of life in older adults is limited. This study characterized the patient experience of RSV illness in USA older adults and assessed the content validity of the InFLUenza Patient Reported Outcome (FLU‐PRO) in this population.MethodsThis qualitative, non‐interventional, cross‐sectional study included hybrid concept elicitation and cognitive debriefing interviews with 30 individuals (age ≥50 years) with polymerase chain reaction‐confirmed RSV diagnosed within 6 months of screening. Targeted literature review was first conducted to inform the development of interview materials. Webcam or telephone interviews were conducted by qualitative researchers using a semistructured interview guide. Interview transcripts were coded and analyzed using Excel and NVivo software.ResultsAll participants reported impacts on daily activities, social activities, and relationships during RSV disease. Physical functioning was impaired in 25 (83%) participants, and 18 (60%) reported not engaging in leisure activities/hobbies. All nine participants who were working reported major impacts on work. Most (n = 28; 93%) described emotional impacts. A majority (n = 19; 63%) reported symptoms lasting beyond the acute disease stage from a week to >1 month. Symptom concepts reported generally matched FLU‐PRO items and domains. Cognitive debriefing indicated that FLU‐PRO was easy to understand and captured participants' experiences of RSV illness.ConclusionsThis study indicates that RSV disease in adults aged ≥50 years in the USA has substantial impacts on daily life and that the concepts included in FLU‐PRO are appropriate and fit for purpose as a measure of RSV symptoms in this population.
Effects of inhibition of Wnt/beta‐catenin pathway on Amacrine and Muller cells in retinas of zebrafish embryos at different development stages
Authors: Yesilyurt Gozde Alkan , Cark Ozge , Bostanci Aysenur , Akdogan Gulcin Cakan , Unsal Ayse Ipek Akyuz , Ergin Kemal , Eliyatkin Nuket Ozkavruk , Ozhan Gunes 
Published: January 2022

AbstractPurposeThe aim of this study was to investigate the changes of Wnt pathway inhibition on Amacrine and Muller cells in the embryonic period of zebrafish.MethodsZebrafishes divided into two subgroups: control and Wnt signaling pathway inhibited groups. The effect of Wnt inhibition (IWR1) on Amacrine and Müller cells were examined at 24th, 38th, 60th and 72nd hours of Zebrafish embryos. Immunofluorescence imaging and in situ hybridization methods were used to compare the ocular structures of the groups treated with glutamine synthetase, calretinin, Neuro D1 (Amacrine and Muller cell markers), Pax6 and Rx3 (genes effective in eye formation).ResultsThe most striking results of our study are; the diminished overall cellular structures of neuroretina at the 24th, 60th hour with Neuro D1, decreased Phospho‐Beta‐catenin staining at the 24th hour, apoptosis of whole ocular tissues at the 24th hour with Cleaved Caspase 3, no staining with glutamine synthase at the 38th hour, reduced β‐Catenin staining in the 60th hour and increased Caspase 3 staining at 72nd hour in IWR group. The related figures (Fig 1–7) are shown below.ConclusionsThe results of our study revealed that the inhibition of the Wnt/beta‐catenin pathway could be responsible for the maldevelopment of ocular tissues especially on the neuroretinal tissues including Amacrine and Muller cells at the early stages. Our results could shed a light on the pathophysiology of developmental anomalies of ocular tissues like colobomas and be a new model for other experimental researches like retinopathies in the future.
Perceived quality of collaboration in dehydration care among Dutch nursing home professionals: A cross‐sectional study
Authors: Paulis Simone J. C. , Everink Irma H. J. , Halfens Ruud J. G. , Lohrmann Christa , Schols Jos M. G. A. 
Published: January 2022

AbstractAimTo explore the perceived quality of collaboration in dehydration care among nursing and medical staff in Dutch nursing homes.DesignA cross‐sectional study.MethodsAn online questionnaire was administered to nursing and medical staff in February 2020 to assess the quality of collaboration in dehydration care and its influencing factors. Descriptive statistics, chi‐square tests and multinomial logistic regression analysis were used to describe the results and examine differences between groups.ResultsIn total, 695 questionnaires were completed by multiple levels of (specialized) nursing staff and nursing home physicians. The quality of collaboration was assessed as good (23.2%), sufficient (59.4%) and insufficient (17.4%). Predicting factors related to perceiving the quality of collaboration as good were working experience, dehydration training during education and the presence of a dehydration protocol/guideline in the nursing home. Enabling factors related to collaboration in dehydration care were ‘availability of sufficient aids to detect dehydration’, ‘continuity in the care relationship’ and ‘sufficient background data of the resident in the care record’. Factors that hinder collaboration were ‘insufficient knowledge about dehydration among nursing and medical staff’, ‘the absence of a team meeting in which the topic dehydration is discussed’ and ‘insufficient staffing level among nursing and medical staff’.ConclusionCollaboration in dehydration care was generally assessed as sufficient. Participants with >10 years of working experience, who received dehydration training during their education and had a dehydration protocol/guideline available in the nursing home, perceived the quality of collaboration more often as good. Experienced barriers and enablers for collaboration in dehydration care varied between professional groups. Therefore, it is important to gain more insight into (informal) caregivers’ perceptions on what is expected from each other about dehydration care.ImpactCare professionals experience several limiting factors in collaborating in dehydration care. Addressing these factors could optimize dehydration care in Dutch nursing homes.
Are there any color match and color correlation between maxillary anterior teeth?
Authors: Tabatabaian Farhad , Ourang Seyed AmirHossein , Khezri Amir Saleh , Namdari Mahshid 
Published: January 2022

AbstractObjectiveTo evaluate the color match and color correlation between maxillary anterior teeth.Materials and MethodsCIELab values of 1182 intact maxillary anterior teeth in 197 human specimens were measured through spectrophotometry. ∆E00 color differences between similar regions of the same and different type teeth were calculated and compared with perceptibility and acceptability thresholds using 1‐sample t test to evaluate color matches. Regression analyses assessed linear relationships between the color coordinates of similar regions of different type teeth. Percentages of different modes of the color match between the same specimen's teeth (2‐tooth/3‐tooth color match or color mismatch) were determined.ResultsMean ∆E00 values for the same type teeth were less than 1.8 (p = 1). Mean ∆E00 values for different type teeth were mostly greater than 1.8 (p < 0.001), except for central and lateral teeth in middle (p = 0.29) and incisal (p = 0.75) regions and for lateral and canine teeth in cervical regions (p = 0.33). The 2‐tooth color match showed the highest percentage (>50%).ConclusionsThe same type teeth indicated color matches. Central and lateral teeth showed color matches in middle and incisal regions, while lateral and canine teeth disclosed color matches in cervical regions. The corresponding color coordinates of mismatched regions were linearly correlated.Clinical SignificanceIn order to predict and determine the shade of maxillary anterior teeth and create natural colors for corresponding restorations, some tooth color relationships and equations are presented in this study.
Predicting melatonin suppression by light in humans: Unifying photoreceptor‐based equivalent daylight illuminances, spectral composition, timing and duration of light exposure
Authors: Giménez Marina C. , Stefani Oliver , Cajochen Christian , Lang Dieter , Deuring Gunnar , Schlangen Luc J. M. 
Published: January 2022

AbstractLight‐induced melatonin suppression data from 29 peer‐reviewed publications was analysed by means of a machine‐learning approach to establish which light exposure characteristics (ie photopic illuminance, five α‐opic equivalent daylight illuminances [EDIs], duration and timing of the light exposure, and the dichotomous variables pharmacological pupil dilation and narrowband light source) are the main determinants of melatonin suppression. Melatonin suppression in the data set was dominated by four light exposure characteristics: (1) melanopic EDI, (2) light exposure duration, (3) pupil dilation and (4) S‐cone‐opic EDI. A logistic model was used to evaluate the influence of each of these parameters on the melatonin suppression response. The final logistic model was only based on the first three parameters, since melanopic EDI was the best single (photoreceptor) predictor that was only outperformed by S‐cone‐opic EDI for (photopic) illuminances below 21 lux. This confirms and extends findings on the importance of the metric melanopic EDI for predicting biological effects of light in integrative (human‐centric) lighting applications. The model provides initial and general guidance to lighting practitioners on how to combine spectrum, duration and amount of light exposure when controlling non‐visual responses to light, especially melatonin suppression. The model is a starting tool for developing hypotheses on photoreceptors’ contributions to light's non‐visual responses and helps identifying areas where more data are needed, like on the S‐cone contribution at low illuminances.
Abstract PR04: CRISPR-mediated PTPN2 deletion in CAR T cells enhances anti-tumor efficacy
Authors: Du Xin , Wiede Florian , Darcy Phillip K. , Tiganis Tony 
Published: January 2022

Abstract
Chimeric Antigen Receptor T cell (CAR T) immunotherapy has been remarkably successful in the treatment of B-Cell Acute Lymphoblastic Leukemia (B-ALL). However, beyond hematological malignancies, CAR T cells have been ineffective in treating solid tumors. Novel approaches for enhancing the ability of CAR T cells to combat solid tumors are urgently required. Protein tyrosine phosphatases (PTPs) are enzymes that regulate a wide range of physiological processes including metabolism, cellular growth, proliferation and differentiation by controlling tyrosine phosphorylation-dependent signaling. PTPs are key regulators of T cell signaling and contribute to the maintenance of immune tolerance. Studies from our group have shown that PTPN2 plays pivotal role in negatively regulating T cell receptor (TCR) signaling by dephosphorylating and inactivating the Src family protein tyrosine kinase LCK (Wiede, Shields et al. 2011). PTPN2 also attenuates cytokine signaling by dephosphorylating JAK-1, JAK-3 and their target substrates STAT-1, -3 and -5 in a cell context-dependent manner (Simoncic, Lee-Loy et al. 2002, ten Hoeve, de Jesus Ibarra-Sanchez et al. 2002, Wiede, Shields et al. 2011, Wiede, La Gruta et al. 2014). Since CARs signal via LCK, and cytokine signaling is critical for CAR T cell function, we postulated that inhibiting PTPN2 might bolster the anti-tumor activity of CAR T cells. Here we used CRISPR-Cas9-ribonucleoprotein (RNP)-mediated genome editing to delete PTPN2 in CAR T cells. Using this approach PTPN2 was efficiently deleted in CAR T cells and the deletion of PTPN2 significantly enhanced the anti-tumor efficacy of CAR T cells in vitro and in vivo.
This abstract is also being presented as Poster P004.
Citation Format: Xin Du, Florian Wiede, Phillip K. Darcy, Tony Tiganis. CRISPR-mediated PTPN2 deletion in CAR T cells enhances anti-tumor efficacy [abstract]. In: Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy; 2021 Oct 5-6. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(1 Suppl):Abstract nr PR04.
Legitimacy, trust and legal cynicism: a review of concepts
Authors: Oliveira Thiago R. , Jackson Jonathan 
Published: January 2022

We review the concepts of legitimacy, trust, and legal cynicism in the context the debate about police legitimacy, discuss the extent to which these concepts relate to each other, and offer some early, speculative thoughts on a how relational model of legitimacy can extend beyond procedural justice concerns. Relying upon procedural justice theory, we emphasise the distinction between police legitimacy and legitimation: popular legitimacy is defined as public beliefs that legal authority has the right to rule (people acknowledge the oral appropriateness of legal authority) and the authority to govern (people recognise legal authority as the rightful authority), whereas legitimation is related to the criteria people use to judge the normative appropriateness of legal agents’ exercise of power (e.g., the extent to which police officers are trustworthy to behave in accordance with people’s normative expectations). Building on studies on legal cynicism and legal socialisation, we consider how other aspects of police conduct can send negative relational messages about people’s value within society and undermine their judgements about the legitimacy of legal authority – messages of oppression, marginalisation, and neglect over the life course. We conclude suggesting avenues for future research on public-police relations.
Women on the Move in the New Testament
Authors: Solevåg Anna Rebecca 
Published: January 2022

Abstract
This article discusses the relation between gender and migration in the New Testament. Six cases of women on the move are presented: Mary, the mother of Jesus; the women in the Jesus movement; three women from the first generation of Christ-believers, Prisca, Lydia and Phoebe; and the unnamed slave woman from Acts 16:16. It is argued that these cases reveal a variety of causes for migration and also depict women who are quite different when it comes to social location and power. The article also discusses the importance of migrant networks in the first century, including religious networks such as the Jewish diaspora. It is argued that women played a key role in the migrant networks presented in New Testament texts.
Reflections on Oppression, Domination, and The Humble Cosmopolitan
Authors: Lee Fred 
Published: January 2022

Abstract
This brief response to The Humble Cosmopolitan centers on Luis Cabrera’s defense of an individualistic conception of trans-state democracy against illiberal nationalist claims of self-determination. While I acknowledge the force of Cabrera’s critique as applied to “dominant” nationalisms and similar group-based dominations, I am curious as to how far Cabrera’s critique can accommodate “subaltern” nationalisms and related claims to group autonomy. The latter, I imply, can be defended on both instrumental and intrinsic grounds. Regarding the book’s analytic framework, I am curious as to how far Cabrera’s concepts of cosmopolitan humility and national-state arrogance can be reduced to concepts of global and national justice and injustice. The latter terms, I suggest, are at least partial substitutes for the former.
The Authoritarian Temptation, and Its Radical Left Expressions
Authors: Whitehead Laurence 
Published: January 2022

Abstract
No political regime can be entirely immune from authoritarian temptations. This article focuses on the distinctive sources and dynamics that apply to post-revolutionary regimes. To prevail in bringing about radical and irreversible change they will require an effective security apparatus that overcomes the backlash that will arise from the previous order. These security requirements provide the first source of authoritarian temptation, but there are three more. Once the regime is firmly established the new rulers can choose what restraints on their conduct to accept. It is tempting to dispense with healthy channels of feedback. Moreover, even the most successful of revolutionary regimes polarise opinion between the old order and the new. And when material hardships arise loyalty may be rewarded above market rationality. In conjunction these amount to a serious set of authoritarian temptations. But there are also some countervailing considerations. A durably successful radical regime must counterbalance the requirements for unity and discipline against the need for creativity and adaptability. Initial emancipatory ambitions may be updated and renewed in order to inspire future generations and legitimise the revolutionary process. Such regimes can seesaw between authoritarian and empowering tendencies, rather than relying on repression alone to keep them in existence. Their legitimation strategy will contain three main components: i) reaffirming and updating their emancipatory origins; ii) downplaying/excusing any authoritarian “deviations”; iii) projecting future prospects for inclusionary development.
Latin American Populist Authoritarian Inclusion
Authors: de la Torre Carlos 
Published: January 2022

Abstract
This article discusses how scholars have analyzed left populist governments in Latin America that include the previously excluded on the condition of their loyalty to the leader. It shows how different normative understandings of democracy have allowed the classification of populism as democratizing, a risk to democracy that could lead to competitive authoritarianism, or a sui generis combination of inclusion and authoritarianism. The paper distinguishes inclusion from democratization, and populists seeking power, from populists in governments, and populist regimes. It argues that the notion of polarized populist democracies captures better their autocratic and inclusionary practices. Populists maintain a commitment to elections hence selectively preserving rights to pluralism, free expression, and association. At the same time, they are authoritarian because populist leaders assume that they embody the people and consider that a section of the population represents the people as a whole, and that their mission is to redeem the people.
Recalibrating Our Levels of Analysis: Working towards Islamic Democracy from the Ground-Up
Authors: Kaminski Joseph J. 
Published: January 2022

Abstract
This review article aims to challenge Andrew March’s pessimism regarding the possibility of Islamic democracy in the modern world. It will argue that instead of conceptualizing the possibilities for Islamic democracy in a top-down manner, rooted in the language and imaginary of sovereignty, discussions about Islamic democracy ought to first focus on more empirically measurable and less theologically controversial things such as economic development, educational achievement, institutional functionality, and good governance. Such an approach removes the need for future Islamic political theorizing to be post-sovereigntist and/or post-statist as March contends. Instead, the future of Islamic political theorizing needs to actually be ‘political,’ addressing the same policy and administrative issues that any other form of contemporary democratic political thought aims to address.