bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a cardiovascular diseases risk prediction model for Chinese males (CVDMCM)
Authors: Shan Ying , Zhang Yucong , Zhao Yanping , Lu Yueqi , Chen Bangwei , Yang Liuqiao , Tan Cong , Bai Yong , Sang Yu , Liu Juehan , Jian Min , Ruan Lei , Zhang Cuntai , Li Tao 
Published: November 2022

BackgroundDeath due to cardiovascular diseases (CVD) increased significantly in China. One possible way to reduce CVD is to identify people at risk and provide targeted intervention. We aim to develop and validate a CVD risk prediction model for Chinese males (CVDMCM) to help clinicians identify those males at risk of CVD and provide targeted intervention.MethodsWe conducted a retrospective cohort study of 2,331 Chinese males without CVD at baseline to develop and internally validate the CVDMCM. These participants had a baseline physical examination record (2008–2016) and at least one revisit record by September 2019. With the full cohort, we conducted three models: A model with Framingham CVD risk model predictors; a model with predictors selected by univariate cox proportional hazard model adjusted for age; and a model with predictors selected by LASSO algorithm. Among them, the optimal model, CVDMCM, was obtained based on the Akaike information criterion, the Brier's score, and Harrell's C statistic. Then, CVDMCM, the Framingham CVD risk model, and the Wu's simplified model were all validated and compared. All the validation was carried out by bootstrap resampling strategy (TRIPOD statement type 1b) with the full cohort with 1,000 repetitions.ResultsCVDMCM's Harrell's C statistic was 0.769 (95% CI: 0.738–0.799), and D statistic was 4.738 (95% CI: 3.270–6.864). The results of Harrell's C statistic, D statistic and calibration plot demonstrated that CVDMCM outperformed the Framingham CVD model and Wu's simplified model for 4-year CVD risk prediction.ConclusionsWe developed and internally validated CVDMCM, which predicted 4-year CVD risk for Chinese males with a better performance than Framingham CVD model and Wu's simplified model. In addition, we developed a web calculator–calCVDrisk for physicians to conveniently generate CVD risk scores and identify those males with a higher risk of CVD.
Predictive ability of obesity- and lipid-related indicators for metabolic syndrome in relatively healthy Chinese adults
Authors: Duan Yuting , Zhang Weiguang , Li Zhe , Niu Yue , Chen Yizhi , Liu Xiaomin , Dong Zheyi , Zheng Ying , Chen Xizhao , Feng Zhe , Wang Yong , Zhao Delong , Liu Qiu , Li Hangtian , Peng Huifang , Sun Xuefeng , Cai Guangyan , Jiang Hongwei , Chen Xiangmei 
Published: November 2022

Background and objectiveMetabolic syndrome (MetS) is an important risk factor for cardiovascular complications and kidney damage. Obesity- and lipid-related indices are closely related to MetS, and different indices have different predictive abilities for MetS. This study aimed to evaluate the predictive value of eight obesity- and lipid-related indicators, namely, body mass index (BMI), lipid accumulation product (LAP), body roundness index (BRI), Chinese visceral adiposity index (CVAI), body adiposity index (BAI), abdominal volume index (AVI), triglyceride glucose index (TYG), and visceral adiposity index (VAI), for MetS.MethodsA total of 1,452 relatively healthy people in Beijing were enrolled in 2016, and the correlation between the eight indicators and MetS was analyzed by multivariate logistic regression. The receiver operating characteristic (ROC) curve and the area under the curve (AUC) were used to analyze the predictive ability of the eight indicators for MetS. The Delong test was used to compare the AUC values of the eight indicators. MetS was defined according to the Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes (2020 edition), the revised National Cholesterol Education Program Adult Treatment Group (NCEP-ATPIII), and the International Diabetes Federation (IDF).ResultsUsing these three sets of criteria, LAP, TYG, CVAI, and VAI, which are based on blood lipids, had higher AUC values for MetS prediction than BMI, BRI, AVI, and BAI, which are based on anthropometry. LAP had the highest AUC values of 0.893 (0.874–0.912), 0.886 (0.869–0.903), and 0.882 (0.864–0.899), separately, based on the three sets of criteria.ConclusionThe eight obesity- and lipid-related indicators had screening value for MetS in relatively healthy people, and of the eight indicators, LAP performed the best.
The role of vitamin D on rotator cuff tear with osteoporosis
Authors: Liu Gejun , Li Wenjun , Zhang Liyun , Zhou Chao , Cong Ruijun 
Published: November 2022

BackgroundsOsteoporosis (OP) is an important risk factor for rotator cuff tears (RCTs). However, the relationship and mechanism between rotator cuff injury and osteoporosis are unclear. Therefore, to investigate association between rotator cuff injury and osteoporosis, and find clinical characteristics, bone mineral density, bone metabolism markers, and nutrient levels in rotator cuff injury patients with or without osteoporosis.MethodsOne hundred and four cases of patients (RCTs, n=32; RCTs-OP, n=72) who underwent rotator cuff injury and need arthroscopic rotator cuff repair between June 2021 and February 2022, along with the diagnosis of osteoporosis were identified from the dual-energy X-ray bone density screening(DXA). The outcome measure includes clinical characteristics, bone mineral density, bone metabolism markers, vitamins, and amino acids. Multivariable logistic regression analysis was applied to build a predicting model incorporating the feature selected in the least absolute shrinkage and selection operator regression model. Discrimination, calibration, and clinical usefulness of the predicting model were assessed using the C-index, calibration plot, and decision curve analysis. Internal validation was assessed using bootstrapping validation.ResultsOP with RCTs has a lower level of in 25-vitD, osteocalcin (OCN), serum Ca2+, ornithine, diaminocaproic_acid but the high level of Vitamin_B12, PTH, Vitamin_D3,γ_aminobutyric_acid, Vitamin_C and Vitamin_E than RCTs patients without OP. Predictors contained in the prediction nomogram included lumber T score, femur T score, Niacin_B3, and vitamin D, reflecting the combined effect of vitamins on RCTs-related OP progression. The model has good discriminative ability with a C-index of 0.938(95% CI:-1.83-1.39) and good scaling ability. The high C-index value of 0.95 is still achievable with range validation. Analysis of decision curves showed that non-adherence is clinically useful when intervention decisions are at the 14% probability limit of non-adherence.ConclusionThis study supports the hypothesis that lumber T score, femur T score, Niacin_B3, and Vitamin D are valuable prognostic biomarkers on RCTs related OP progression.What is known about the subjectIt is found that vitamin D are valuable prognostic biomarkers, reflecting the combined effect of vitamins on RCTs related OP progression.What this study adds to existing knowledgeThese findings also highlight that nutrients condition such as vitamins and amino acids of patients provide a new understanding of the development of RCTs.
Effects of obesity indices/GDM on the pregnancy outcomes in Chinese women: A retrospective cohort study
Authors: Song Zhimin , Cheng Yan , Li Tingting , Fan Yongfang , Zhang Qingying , Cheng Haidong 
Published: November 2022

ObjectiveTo analyze pregnancy complications and outcomes of mothers with obesity or gestational diabetes mellitus (GDM).Methods15065 mothers were categorized into four and three groups by pre-pregnancy body mass index (preBMI) and abdominal circumference (AC), respectively, or divided into GDM or non-GDM groups. Logistic regression analysis was utilized to identify independent factors associated with pregnancy complications and outcomes.ResultsThe overweight and obesity groups accounted for 16.0% and 4.0% of the total population, respectively. GDM incidence rate was 12.3%. The overweight and obesity groups (pre-pregnancy body mass index [preBMI] ≥ 24 kg/m2) were at higher risks for GDM, hypertensive disorders of pregnancy (HDP), gestational proteinuria, postpartum hemorrhage, preterm delivery, fetal malformation or stillbirth, neonatal asphyxia, large for gestational age (LGA), shoulder dystocia, and increased cesarean section rate. Similar results were obtained with AC grouping. GDM pregnant women had higher risks of HDP, preterm delivery, small for gestational age (SGA), LGA, and increased cesarean section rate.ConclusionPeople with obesity had a higher risk of adverse pregnancy outcomes. The recommended preBMI is 19.2-22.7 kg/m2. The recommended AC at 11-13+6 gestational weeks is 74.0-84.0 cm, and that value in normal preBMI is 74.0-82.0 cm.
Correlation of thyroid-related hormones with vascular complications in type 2 diabetes patients with euthyroid
Authors: Lin Jie , Xiang Xin , Qin Yahui , Gui Jing , Wan Qin 
Published: November 2022

BackgroundThis study aimed to evaluate the relationship between thyroid-related hormones and vascular complications in type 2 diabetes mellitus (T2DM) patients with euthyroidism.MethodsWe enrolled 849 patients with T2DM after screening out the ineligible. Multivariate logistic regression was used to analyze the relationship between fT3, fT4, the fT3/fT4 ratio, thyroid-stimulating hormone, and diabetic vascular complications. Spearman correlation analysis was used to determine the correlation between thyroid-related hormones and vascular complications.ResultsIn this cross-sectional study of T2DM, 538 patients with carotid atherosclerosis (CA) and 299 patients with diabetic peripheral neuropathy (DPN). The prevalence of DPN was negatively correlated with fT3 and the fT3/fT4 ratio but positively correlated with fT4 (all P&lt;0.01). At the same time, the odds ratio for DPN decreased with increasing fT3 (T1: reference; T2: OR: 0.689, 95%CI: 0.477, 0.993; T3: OR: 0.426, 95% CI: 0.286, 0.633, all P&lt;0.05) and fT3/fT4 ratio (T1: reference; T2: OR: 0.528, 95% CI: 0.365, 0.763; T3: OR: 0.413, 95% CI: 0.278, 0.613, all P&lt;0.001). In terms of sensitivity and specificity, fT4 was found to be 39.5% and 71.4% accurate, respectively, with a 95% CI of 0.531-0.611.ConclusionsWe found a negative correlation between fT3 and fT3/fT4 ratio and the number of individuals with DPN, and a positive correlation between fT4 and the prevalence of DPN.
Influence of a complex impeller with tip clearance on the internal and external characteristics of a multiphase pump
Authors: Yao Xin , Shi Guangtai , Wen Haigang , Huang Zongliu 
Published: November 2022

With the exploitation of deep sea and desert oil fields, multiphase pumps have come into the public eye. However, due to the nature of the medium and operating environment, the performance of traditional multiphase pumps has diminished, leading to problems such as increased recovery cycles and rising costs. In order to obtain a high-head, high-reliability multiphase pump, this paper uses the model optimization method to design a complex pattern impeller. The best complex impeller with 17.25% increase in head was selected with the external characteristics as the optimization index, and a comparative analysis of the internal flow field was carried out between the complex impeller and original impeller when the inlet gas volume fraction was 10%. The results show that in the complex impeller, the short blade reduced the proportion of the high-speed zone, inhibited the appearance of the main blade suction surface low-speed zone, and significantly improved the return flow. The slope of the pressure boosting curve at the relative position 1.5–2.0 was increased, and the pressure boosting capacity was increased by 16.34 kPa. The short blade weakens the leakage movement while reducing the pressure effect on the main blade. In addition, the short blade not only improved the gas phase gathering but also reduced its size and made it closer to the main blade suction surface, which improved the uniformity of the gas phase distribution in the flow channel and also enhanced the inlet flow capacity. The results can provide a reference for future optimization and performance improvement of multiphase pump models.
Dynamic changes in soil moisture in three typical landscapes of the Heihe River Basin
Authors: Gou Qianqian , Guo Wenting , Li Yuda , Liu Jing , Wang Guohua 
Published: November 2022

The water diversion scheme of Heihe River Basin was implemented in 2000. Herein, we investigated the dynamic changes in soil moisture content and analyzed the fundamental reasons supporting the water diversion plan in this typical inland river basin in northwest China. Accordingly, we selected three typical landscape gradients—a mountain water conservation forest belt, an artificial sand-fixing forest belt at the edge of a desert oasis, and a desert riparian forest belt in the upper, middle, and lower reaches of the Heihe River Basin, respectively. In these diverse landscapes, an environmental measuring system was used to continuously monitor the dynamic and differentiation regularity of soil moisture in the 0–160 cm layer for 5 years. The results revealed that 1) the soil moisture content in each landscape increased and varied significantly across seasons. In the upper and middle reaches, the soil moisture content was significantly higher during the growing season than in the non-growing season, whereas the lower reach displayed a converse pattern. 2) The distribution of soil moisture at various depths of soil profiles varied significantly for each landscape. As the soil depth increased, the soil moisture in the upper reach decreased. Although the deep layers (120–160 cm) could store water in the non-growing season, the stored water was consumed during the growing season. The soil moisture content in the mid-reach initially increased, later decreased, and ultimately attained its highest level at 40–60 cm; however, the soil moisture content in the lower reach increased, and reached its highest level at 120–160 cm. 3) In the upper and middle reaches, the coefficient of variation of soil moisture decreased with an increasing soil depth, whereas the lower reach exhibited a converse trend. Similarly, the coefficient of variation of soil water storage were higher during the non-growing season than during the growing season within the upper and middle reaches, whereas an opposite trend was observed in the lower reach. 4) Since the implementation of the Heihe river water diversion plan, the soil moisture content in both the upper and middle reaches have increased but that of the lower reach has fluctuated and declined, especially in the shallow depths during the growing season. The present findings imply that the lower reaches of the Heihe River may require additional water transfers during the growing season.
Transcriptomic study reveals lncRNA-mediated downregulation of innate immune and inflammatory response in the SARS-CoV-2 vaccination breakthrough infections
Authors: Chattopadhyay Partha , Mishra Pallavi , Mehta Priyanka , Soni Jyoti , Gupta Rohit , Tarai Bansidhar , Budhiraja Sandeep , Pandey Rajesh 
Published: November 2022

IntroductionThe emergence of multiple variants of concerns (VOCs) with higher number of Spike mutations have led to enhanced immune escape by the SARS-CoV-2. With the increasing number of vaccination breakthrough (VBT) infections, it is important to understand the possible reason/s of the breakthrough infections.MethodsWe performed transcriptome sequencing of 57 VBT and unvaccinated COVID-19 patients, followed by differential expression and co-expression analysis of the lncRNAs and the mRNAs. The regulatory mechanism was highlighted by analysis towards repeat element distribution within the co-expressed lncRNAs, followed by repeats driven homologous interaction between the lncRNAs and the promoter regions of genes from the same topologically associated domains (TAD).ResultsWe identified 727 differentially expressed lncRNAs (153 upregulated and 574 downregulated) and 338 mRNAs (34 up- and 334 downregulated) in the VBT patients. This includes LUCAT1, MALAT1, ROR1-AS1, UGDH-AS1 and LINC00273 mediated modulation of immune response, whereas MALAT1, NEAT1 and GAS5 regulated inflammatory response in the VBT. LncRNA-mRNA co-expression analysis highlighted 34 lncRNAs interacting with 267 mRNAs. We also observed a higher abundance of Alu, LINE1 and LTRs within the interacting lncRNAs of the VBT patients. These interacting lncRNAs have higher interaction with the promoter region of the genes from the same TAD, compared to the non-interacting lncRNAs with the enrichment of Alu and LINE1 in the gene promoter.DiscussionSignificant downregulation and GSEA of the TAD gene suggest Alu and LINE1 driven homologous interaction between the lncRNAs and the TAD genes as a possible mechanism of lncRNA-mediated suppression of innate immune/inflammatory responses and activation of adaptive immune response. The lncRNA-mediated suppression of innate immune/inflammatory responses and activation of adaptive immune response might explain the SARS-CoV-2 breakthrough infections with milder symptoms in the VBT. Besides, the study also highlights repeat element mediated regulation of genes in 3D as another possible way of lncRNA-mediated immune-regulation modulating vaccination breakthroughs milder disease phenotype and shorter hospital stay.
Association of mean platelet volume/lymphocyte ratio with inflammation in non-dialysis patients with chronic kidney disease stages 1–4: A retrospective study
Authors: Xu Bei , Zhang Yamei , Chen Gang , Feng Jiafu , Gan Lingling 
Published: November 2022

ObjectiveThe mean platelet volume/ratio (MPVLR) is recognized as a novel marker of inflammation. We evaluated whether the MPVLR is associated with inflammation in non-dialysis patients with chronic kidney disease (CKD) stages 1–4.MethodsA total of 402 non-dialysis patients with CKD stages 1–4 were included. The indicators of hematological, renal function (urea, serum creatinine [Scr], estimated glomerular filtration rate [eGFR], and urine albumin to creatinine ratio [ACR]) and the markers of inflammation (high-sensitivity C-reactive protein [hsCRP] and fibrinogen [FIB]) were recorded. The MPVLR values at different CKD stages were analyzed. Next, based on the absence (hsCRP level &lt; 5 mg/L) and presence (hsCRP level &gt; 5 mg/L) of inflammation, the patients were categorized, and the differences in indices between the two groups were observed. The patients were divided into two groups based on the median MPVLR value (6.39) at admission. The laboratory indices of patients with CKD were compared. Simultaneously, a correlation analysis was performed to identify the association between the MPVLR and each parameter. A binary logistic regression analysis was performed to test whether the MPVLR was associated independently with the presence of inflammation in non-dialysis patients with CKD. The receiver operating characteristic (ROC) curve was used to analyzed diagnostic performance of the MPVLR in evaluating the inflammation of non-dialysis patients with CKD stages 1-4.ResultsThe MPVLR was higher in patients with CKD stages 3–4 than in those with CKD stages 1 and 2. Significant differences in urea, Scr, eGFR, ACR, lymphocyte (LYM), red blood cell (RBC), hemoglobin (HGB), RBC distribution width (RDW-CV), MPVLR, and FIB values were observed between the groups with and without inflammation. The patients with a higher MPVLR had higher urea, Scr, ACR, WBC, neutrophils (NEU), RDW-CV, platelet distribution width (PDW), mean platelet volume (MPV), and hsCRP values and lower eGFR, LYM, RBC, HGB, and platelet (PLT) values. The MPVLR showed a positive correlation with age, urea, Scr, WBC, NEU, RDW-CV, PDW, MPV, and hsCRP values and a negative correlation with the eGFR, LYM, RBC, HGB, and PLT values. A logistic analysis revealed that the MPVLR was associated independently with the presence of inflammation in non-dialysis patients with CKD, after adjustment for the confounding factors (odds ratio = 1.020; P = 0.024). Furthermore, MPVLR exhibited a modest diagnostic performance for the assessment of inflammation in non-dialysis patients with CKD stages 1-4, with an area under the curve (AUC) of 0.706, and the sensitivity, specificity being 46.2% and 83.2%, respectively.ConclusionsThe MPVLR was associated independently with the presence of inflammation in non-dialysis patients with CKD and may be useful for monitoring inflammation.
Atomistic simulations of dislocation plasticity in concentrated VCoNi medium entropy alloys: Effects of lattice distortion and short range order
Authors: Esfandiarpour Amin , Alvarez-Donado Rene , Papanikolaou Stefanos , Alava Mikko 
Published: November 2022

Face-centered cubic (fcc) high and medium entropy alloys (H/MEAs) have been shown to display superior mechanical properties at low temperatures, but significant improvement of their strength at high temperatures is required for industrial applications at extreme conditions. Recently, it has been shown that the breakthrough of the MEAs from equiatomic/near-equiatomic to non-equiatomic ratios leads to strong MEAs with good ductility. To design new H/MEAs, we consider two important factors that may influence strength: the chemical composition and chemical short range order (CSRO). In this study, we investigate the depinning stress (σc) as a criterion of strength of several compositions of VCoNi concentrated solid solution alloys (CSSAs) including V0.33Co0.33Ni0.33, V0.35Co0.2Ni0.45, V0.33Co0.17Ni0.5, and V0.17Co0.33Ni0.5 at 5 K and 300 K, using atomistic simulations. The chosen interatomic potential is shown to be reliable by comparing experimental/ab initio values and calculated parameters such as lattice constant, shear modulus, depinning stress, and temperature variation of stacking fault width for equimolar VCoNi. We find a good agreement between experimental friction stress and the depinning stress extracted from our results for equimolar VCoNi. Also, we find that Vclusters are the main pinning points of dislocations, and With a random distribution of atoms, we find that the alloy composition V0.33Co0.17Ni0.5 displays the largest depinning stress at both 5 and 300 K. Furthermore, to investigate how CSRO affects the strength of these alloys, we design CSRO into the microstructure using two different methods: In the first method, hybrid Molecular-dynamics/Monte-Carlo simulations were employed to simulate annealing at various temperatures. We observe that such simulations create CSRO so that it increases with decreasing annealing temperature. Recently, the CSRO motif and its concentration in an equimolar VCoNi have been determined by experiment. By modeling this experiment, we also implemented the CSRO into microstructure as the second method. By using both methods, the effect of CSRO on the magnitude of the depinning stress is discussed. It was shown that in both methods, CSRO significantly influences the strength of non-equimolar VCoNi alloys.