bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rectal ectopic pregnancy after in vitro fertilization and embryo transfer: A case report
Authors: Wang Chujun , Xiong Yipin , Liu Fengzhen , Qiu Lijuan , Zhang Chun-Quan 
Published: November 2022

Rationale:
Rectal ectopic pregnancy is an extremely rare abdominal pregnancy. This article presents a female underwent an unsuccessful in vitro fertilization which was misdiagnosed by serum beta-human chorionic gonadotropin (β-hCG) test and transvaginal ultrasonography. Twenty days later, a ruptured rectal ectopic pregnancy was confirmed by laparoscopy then the gestational tissue removed successfully.

Patient concerns:
A 32-year-old Chinese female was admitted to our hospital with complaining of symptoms, like gradual worsening of lower abdominal pain and dysuria. The abdominal ultrasonography revealed a sac-like mass in the posterior area to the uterus and a moderate amount of free fluid in the pelvic cavity. Forty days ago, she underwent a frozen embryo transfer. Twenty days ago, her serum β-hCG level was <5 mIU/mL and neither intrauterine nor ectopic pregnancy was detected by transvaginal ultrasonography. Then the procedure was thought to have resulted in biochemical pregnancy failure.

Diagnosis:
The primary rectal ectopic pregnancy.

Interventions:
The mass was removed laparoscopic surgery.

Outcomes:
The patient recovered well.

Lessons:
When the history of in vitro fertilization combined with an inappropriate rise of serum β-hCG and no visible evidence of an intra-uterine pregnancy, physicians should consider the possibility of abdominal pregnancy. Early diagnosis of abdominal pregnancy can effectively save the life of the pregnant woman.
Unexpected cholinergic crisis caused by distigmine bromide: A case report
Authors: Sera Toshiki , Kusunoki Shinji , Shime Nobuaki 
Published: November 2022

Rationale:
Distigmine bromide is a cholinesterase (ChE) inhibitor used to treat dysuria due to a hypotonic bladder. We encountered a case of cholinergic crisis caused by distigmine bromide, which resulted in a rapid decrease in serum ChE levels, hypothermia, respiratory failure, and circulatory failure within a short period of time.

Patient concerns:
A 51-year-old man was admitted to a psychiatric hospital to treat behavioral disorders due to irritability and violent behavior. The patient was referred to our hospital for septic shock secondary to urinary tract infection and respiratory failure. He had not defecated for 5 days before visiting our hospital. He had moderate intellectual disability. Immediately after admission, he developed hand tremors and drooling. The airway was obstructed by drooling due to vomiting of yellow clear gastric juice.

Diagnosis:
The patient’s high saliva volume, bradycardia, respiratory failure (54 breaths/min), constricted pupils (2.5/mm), poor oxygenation, and a history of oral medication were consistent with the diagnosis of cholinergic crisis due to distigmine bromide.

Interventions:
On admission, the patient was immediately intubated. He was treated with noradrenaline (0.1 µg/kg/min) to increase his blood pressure. He was admitted to the intensive care unit (ICU). Since he had circulatory failure, vasopressin (approximately 1 U/h) was administered. Continuous intravenous atropine sulfate (0.6 mg/h) was also administered for high saliva volume.

Outcomes:
On the 8th ICU day, the patient’s drooling and bradycardia improved. The patient was physically and mentally stable, and transferred to the referring hospital.

Lessons:
ChE levels and symptoms before onset may not be useful for the early detection and prevention of adverse effects of cholinergic crisis caused by distigmine bromide. In addition to known risks such as renal impairment and older age, constipation should be recognized and communicated as a risk factor.
Acupotomy by ultrasound-guided versus anatomical guidance in knee osteoarthritis: A protocol for systematic review and meta-analysis
Authors: Wang Li , Wei Jiantong , Qian Zhi , Qian Jun 
Published: November 2022

Background:
At present, there is no systematic evaluation on whether ultrasonic-guided acupotomy is more effective compared with anatomical guidance in knee osteoarthritis. We conducted a protocol for systematic review and meta-analysis to provide a method for evaluating the effectiveness and safety of acupotomy by ultrasound-guided technique.

Methods:
An all-round retrieval will be performed in the following electronic journal databases from their inception to October 2022, which comprise PubMed, MEDLINE, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Wanfang data, Chinese Scientific Journals Database, and China biomedical literature database. The following key words were used on combination with Boolean operators AND or OR: “acupotomy,” “ultrasound,” “knee osteoarthritis.” Two authors completed the quality assessment using the Cochrane Collaborations risk of bias tool. The meta-analysis was conducted using Review Manager 5.3 software from the Cochrane Collaboration (London, UK).

Results:
The findings of this study will be submitted to peer-reviewed journals for publication.

Conclusion:
This systematic review will provide evidence to judge whether acupotomy by ultrasound-guided technique is effective and safe for knee osteoarthritis.
Identification and validation of immune and prognosis-related genes in hepatocellular carcinoma: A review
Authors: Chen Yu-Yang , Zhang Shi-Mao , Zhao Heng-Xia , Zhang Jing-Yue , Lian Li-Rong , Liu De-Liang , Chu Shu-Fang 
Published: November 2022

Purpose:
Bioinformatics methods were used to identify the key genes associated with the immune microenvironment of hepatocellular carcinoma (HCC) to construct an immune risk prognostic model (IRPM) and to study the correlation between IRPM’s risk groups and immune characteristics of patients with HCC.

Methods:
HCC transcriptome sequencing information was searched for immune-related genes (IRGs) that were regularly expressed in cancer tissues. The IRGs, which were strongly linked to overall survival were screened; the prognostic characteristics model was constructed using Cox regression analysis. IRPM’s independent prognostic value was explored; Kaplan–Meier survival and receiver-operating characteristic curves were used to determine the model prediction ability in the led-to queue.

Results:
Patients in the high-risk group (HRG) showed significantly poor outcomes. Gene Set Enrichment Analysis revealed factors involved in both the HRG and low risk group. Immune-related hub genes (IRHGs) and drug sensitivity expression levels revealed that all IRHGs were correlated with drug sensitivity for certain chemotherapy drugs.

Conclusion:
The study results may serve as a reference for improving prognosis, early screening, and immunotherapy in patients with HCC.
Meta analysis of the effect of phloroglucinol combined with progesterone in the treatment of threatened miscarriage before 20 weeks of gestation: A protocol for a systematic review
Authors: Peng Yao , Zhang Jiayuan , Lan Tian , Liu Shengyue , Ye Tao , Wang Yongzhou 
Published: November 2022

Background:
Threatened miscarriage (TM) is an important factor endangering the health of pregnant women. It not only affects women’s physical and mental health, but also destroys family happiness. To treat this disease, it is necessary to find a treatment with better clinical efficacy and fewer side effects. The purpose of this systematic study was to evaluate the efficacy and safety of phloroglucinol (PHL) combined with progesterone in the treatment of TM before 20 weeks of pregnancy.

Methods:
Electronic databases (EMBASE, PubMed, Cochrane Central Register of Controlled Trials, Web of Science, Elsevier, China National Knowledge Infrastructure, Chongqing VIP, and WanFang Data) were searched from inception until September. 2022. Randomized controlled trials of PHL combined with progesterone in the treatment of TM before 20 weeks of gestation will be included, and all articles will be independently screened and collected by 2 reviewers. Revman 5.3.5 software will be used for meta-analysis. The specific process is described in the Cochrane Handbook for Systematic Reviews.

Results:
The efficacy and safety of PHL combined with progesterone for the treatment of threatened abortion were comprehensively evaluated in terms of efficacy, efficiency, time of symptom relief, length of hospital stay, and incidence of adverse events.

Conclusion:
This study provides reliable evidence for the clinical application of PHL combined with progesterone for the treatment of TM.
The efficacy and safety of radiotherapy combined chemotherapy for laryngeal preservation in advanced laryngeal cancer: A protocol for systematic review and meta-analysis
Authors: Zhang Lei , Li Jianfeng , Jia Chenle 
Published: November 2022

Background:
The appropriate use of surgery or chemoradiotherapy-based approaches for organ preservation has been the subject of much debate. Unfortunately, there has been a lack of improvement in overall survival for patients with laryngeal carcinoma. In this study, we performed a protocol for systematic review and meta-analysis to evaluate the efficacy and safety radiotherapy combined chemotherapy for laryngeal preservation in advanced laryngeal cancer

Methods:
This protocol is reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. We will search the PubMed, Cochrane Library, EMBASE, and Web of Science databases from the inception dates to October, 2022, using the keywords “laryngeal cancer,” “radiotherapy”, and “chemotherapy.” Cochrane “bias risk” tool is used to assess the bias risk of the quality of the included literature. All calculations were carried out with RevMan V.5.3 software.

Results:
The results of this study will provide evidence for judging whether radiotherapy combined chemotherapy is superior to surgery for treatment of advanced laryngeal cancer.

Conclusion:
This review will provide directions and recommendations for future research and clinical practices of radiotherapy combined chemotherapy for laryngeal preservation in advanced laryngeal cancer.
Proteomics and genomics of a monomorphic epitheliotropic intestinal T-cell lymphoma: An extremely rare case report and short review of literature
Authors: Boșoteanu Mădălina , Cristian Miruna , Așchie Mariana , Deacu Mariana , Mitroi Anca Florentina , Brînzan Costel Stelian , Bălțătescu Gabriela Izabela 
Published: November 2022

Rationale:
Monomorphic epitheliotropic intestinal T-cell lymphoma, formerly known as enteropathy-associated T-cell lymphoma, is an extremely rare, aggressive peripheral extranodal T-cell lymphoma, that is infrequent in native European and Caucasian populations. The current study presents the clinicopathological features, diagnostic approach, and clinical outcomes of this rare entity of lymphoma and highlights the importance of the early diagnosis of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL).

Patient concerns:
Main symptoms and/or important clinical findings: We present the case of a 69-year-old male patient presenting with an abdominal mass, intestinal transit disorder, and weight loss. The abdominal computed tomography (CT) revealed features suggestive of a malignancy. Following clinical and imaging investigations, surgical resection of the small intestine with other areas of involvement has been performed and further to the histopathological examination and immunohistochemical testing are mandatory.

Diagnoses and Interventions:
Histopathological evaluation of the tumor revealed a proliferation of medium- to large-sized monomorphic lymphocytes, with vesicular nuclei, prominent nucleoli, and a moderate amount of clear to pale eosinophilic cytoplasm, with an association of infrequent Reed-Sternberg-like cells. Immunohistochemical assessment of the aforementioned tumor using CD3, CD8, CD5, CD20, and CD30 confirmed the T cell proliferation line and the monomorphic epitheliotropic intestinal T-cell lymphoma diagnosis.

Lessons:
The current report highlights the importance of early diagnosis of MEITL owing to its poor prognosis and presents histopathological features that help distinguish MEITL from inflammatory bowel diseases and less aggressive T-cell lymphomas.
An unusual case report of porokeratosis ptychotropica on the buttocks
Authors: Xiao Yu , Peng Shanshan , Mao Tianyi , Li Xiangjun , Ye Wenzheng , Fang Muping 
Published: November 2022

Rationale:
Porokeratosis ptychotropica represents an unusual form of porokeratosis characterized by symmetrical dyskeratotic skin lesions on the gluteal clefts. Herein, we report a case of porokeratosis ptychotropica.

Patient concerns:
A 33-year-old man, who complained of itching papules and plaques in the gluteal cleft and the buttocks for the last 7 years. Clinical examination showed a large well-defined reddish brown verrucous plaque located on both buttocks along with satellite papules on the inner thigh. Dermoscopy and histopathological findings were consistent with porokeratosis.

Diagnosis:
He was diagnosed with porokeratosis ptychotropica.

Outcomes:
No significant improvement was observed following treatment with oral acitretin and a topical retinoid.

Lessons:
The case report highlights the need for awareness amongst dermatologists for porokeratosis ptychotropica as a differential diagnosis for pruritic papules in the gluteal fold.
Instagram Use and Mental Well-Being
Authors: Stefana Alberto , Dakanalis Antonios , Mura Matteo , Colmegna Fabrizia , Clerici Massimo 
Published: November 2022

Abstract
Instagram has grown in popularity among young adults and adolescents and is currently the second-favorite social network in the world. Research on its relationship to mental well-being is still relatively small and has yielded contradictory results. This study explores the relationship between time spent on Instagram and depressive symptoms, self-esteem, and disordered eating attitudes in a nonclinical sample of female Instagram users aged 18–35 years. In addition, it explores the mediating role of social comparison. A total of 1172 subjects completed a one-time-only online survey. Three different mediation analyses were performed to test the hypotheses that social comparison on Instagram mediates the association time spent on Instagram with depressive symptoms (model 1), self-esteem (model 2), and disordered eating attitudes (model 3). All three models showed that the relationship between intensity of Instagram use and the respective mental health indicator is completely mediated by the tendency for social comparison on Instagram.
Obsessive-Compulsive Disorder and Metabolic Disorders
Authors: Ding Hui , Ouyang Mengyuan , Wang Jinyi , Xie Minyao , Huang Yanyuan , Yuan Fangzheng , Jia Yunhan , Wang Jun , Liu Na , Zhang Ning 
Published: November 2022

Abstract
Obsessive-compulsive disorder (OCD) has a bidirectional relationship with metabolic disorders. The purposes of this review are to decipher the links between OCD and metabolic disorders and to explore the etiological mechanism of OCD in metabolism, which may aid in early identification of and tailored interventions for OCD and metabolic disorders.
An RGB camera-based fall detection algorithm in complex home environments
Authors: Tian Zhiyu , Zhang Liang , Wang Guoan , Wang Xuefeng 
Published: November 2022

Abstract

Objectives:
Accidental falls are a threat to the well-being of older people. This study aimed to develop a real-time human fall detection system to detect fall behaviors and provide timely medical treatment for older adults.

Methods:
An RGB camera-based fall detection system is designed and it can send alarm messages when a fall occurs. This fall detection system consists of two design aspects: a hardware and a software algorithm. The fall detection algorithm includes (1) algorithm initialization phase to obtain environmental parameters; (2) 2-dimensional pose detection to identify human targets and human joint locations; and (3) limb-length and multiframe fall judgment to confirm the occurrence of falls based on its practical features.

Results:
By combining fall detection algorithms with a hardware system, the test results in complex home environments showed that the system sensitivity was 94.2%, the specificity was 96%, and the accuracy was 94.5%.

Conclusion:
The proposed method is more robust compared with the algorithm based exclusively on action recognition. Using only a monocular camera is cost-friendly and can realize real-time fall detections, and help older people to get timely and effective care after a fall.
Effectiveness of a novel augmented reality cardiopulmonary resuscitation self-training environment for laypeople in China: a randomized controlled trial
Authors: Hou Luoya , Dong Xu , Li Ke , Yang Congying , Yu Yang , Jin Xiaoyan , Shang Shaomei 
Published: November 2022

Abstract

Objectives:
The training rate of cardiopulmonary resuscitation (CPR) among the general population in China is relatively low. Augmented reality (AR) may be an effective method of CPR training, especially where in-person interactions may not be possible. The purpose of this study was to analyze the effectiveness of AR CPR self-training for people who are not professional health care workers.

Methods:
A 2-arm and prospective randomized controlled trial was conducted. Participants were recruited via advertisements from August to October 2021 in Beijing and were randomly assigned to either an AR self-training CPR group (n=82) or an instructor-led training group (n=81). Participants in the AR group spent 25 minutes in a simulated environment using HoloLens to engage them in immersive multisensory CPR self-training. Participants in the instructor-led group received 25 minutes of CPR instruction with the guidance of a certified instructor. The outcomes, including the mean chest compression depth (centimeter) and rate (/min), the proportion of correct positioning of hands, correct rescue breaths, compression accuracy, and the proportion of participants that adhered to the American Heart Association’s CPR guidelines, were compared between the 2 groups.

Results:
The median age of the participants was 23 years old (interquartile range: 22–25) and the median weight was 55 kg (interquartile range: 51–63). The mean difference (95% CI) in the compression rate between the 2 groups [mean (SD): AR 109.03 (2.68)/min vs. instructor-led 110.88 (3.03)/min] was −1.85 (−2.74 to −0.96)/min. The mean difference (95% CI) in the depth of compressions between the groups [mean (SD): AR 5.59 (0.59) cm vs. instructor-led 5.55 (0.47) cm] was 0.04 (−0.13 to 0.20) cm. The AR self-training was noninferior to the instructor-led CPR training, as measured by the rate and depth of compressions (P<0.001). The proportion of participants that adhered to the AHA guideline for compression depth (AR: 65.85% vs. instructor: 72.84%, χ2=0.935, P=0.334) was similar in the 2 groups. The proportion of correct rescue breaths [AR: 64 (78.05%) vs. instructor: 74 (91.36%), P<0.001] were significantly higher in the instructor-led group. Heterogeneity of the effect of AR self-training on the chest-compression rate were found in subgroups of sex (P=0.03 for the interaction) and weight (P=0.03 for the interaction).

Discussion:
The AR self-training and instructor-led training are comparable in terms of both groups’ compression rate and depth. This study may have important implications to improve the CPR training rates in China.
Overutilization of Radiographs for Pulled Elbow Among Orthopedic Surgeons Compared With Pediatricians
Authors: Kadar Assaf , Yaniv Noga , Warschawski Yaniv , Rosenthal Yoav , Shemesh Shai , Weigl Daniel , Frenkel Rutenberg Tal 
Published: November 2022

Background
Pulled elbow is a common pediatric condition, treated by pediatricians and orthopedic surgeons. The diagnosis is clinical, and imaging is only required where an occult fracture is suspected, although overuse is reported. In this study, we explore the epidemiology of pulled elbow in Israel, focusing on the differences in management between physicians of various specialties.

Methods
Electronic medical records of the largest health provider in Israel, which provides health services to more than 50% of the population, were reviewed for pulled elbow cases between 2005 and 2020. Patients aged 4.5 months to 7 years were included. Demographic information, the discipline of the treating physician, and acquisition of elbow radiographs were gathered.

Results
A total of 4357 patients, 62.8% girls, were included. The average body mass index was 16.1 (SD, 1.2). Most patients were from communities in the upper half of the socioeconomic status clusters 6 to 10 (64.63%). Most patients were attended by a pediatrician (51.5%), followed by an orthopedic surgeon (19.9%). Radiographs were acquired for 570 children (13.1%). Most radiographs (36.5%) were requested by orthopedic surgeons and for children in the boundary age groups. The patient's socioeconomic status was associated with access to physicians of different subspecialties, and lower income families had a higher tendency to be treated by nonspecialized physician (P < 0.001).

Conclusions
Orthopedic surgeons use elbow radiographs much more than pediatricians; effort should aim at reducing the imaging rate for this population.
Quenching for a semi-linear wave equation for micro-electro-mechanical systems
Authors: Gimperlein Heiko , He Runan , Lacey Andrew A. 
Published: November 2022

We consider the formation of finite-time quenching singularities for solutions of semi-linear wave equations with negative power nonlinearities, such as can model micro-electro-mechanical systems. For radial initial data we obtain, formally, the existence of a sequence of quenching self-similar solutions. Also from formal aymptotic analysis, a solution to the PDE which is radially symmetric and increases strictly monotonically with distance from the origin quenches at the origin like an explicit spatially independent solution. The latter analysis and numerical experiments suggest a detailed conjecture for the singular behaviour.
Proteo-transcriptomic analysis reveals brain-region-specific gene and biomarker expression in post-mortem neural tissue of Alzheimer’s patients
Authors: Kumar Gokulanath Mahesh 
Published: November 2022

AbstractAlzheimer’s disease is a neurodegenerative disorder, marked by dementia, impaired judgment, and a decline in cognitive abilities, that affects over 50 million people worldwide. The etiology of the disease is influenced by a myriad of genetic and environmental factors including APOE4 allele status and sex and can be characterized by a variety of neuropathological markers, such as amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs) in specific areas of the brain, as well as the dysregulation of certain genes. However, how APOE4 status and sex affect the expression of these biomarkers and the gene dysregulation patterns specific to each brain region have yet to be determined. In this study, statistical and correlational analyses were performed to identify and quantify the relationship between the expression of proteo-transcriptomic biomarkers associated with neurodegenerative disorders and neuronal development in the frontal white matter, parietal cortex, temporal cortex, and hippocampus with patient demographic and genetic information. Further analysis determined whether the observed correlations were brain-region-specific or sex-specific. There was a statistically significant relationship between APOE4 status and degree of Aβ accumulation (P < 0.001) and neurofibrillary tangle formation (P = 0.04). Aβ plaque deposition was found to be more severe in females (P = 0.001) and the intensity of Aβ and NFT formation differed across brain regions (P < 0.001, P = 0.001 respectively). Furthermore, transcriptomic analysis revealed brain-region-specific gene dysregulation patterns. These patterns can identify therapeutic targets for future targeted gene and protein therapies in specific brain regions to treat Alzheimer’s disease.