bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular characterization of Insect Parasitic nematodes, and assonated Symbiotic bacteria as Ecotoxic effect of Invasive insect larvae
Authors: Kasi Indra Kumar , Singh Mohinder , Waiba Kanchhi , Daroch Rakesh Kumar , Sharma PL , Malik Abaker M. , Waseem MA , Rostami Elahe , Mobolade Adesina Jacobs 
Published: July 2022

Abstract
The agro-climatic zones survey was conducted diversity and frequency of endemic entomopathogenic nematodes (EPNs) in Apple orchards in Rajgarh, western Himalayas. Isolated EPNs have been used as an active biocontrol agent against T. absoluta and S. frugiperda. The total survey of 42 locations apple orchards were collected from which 281 soil samples and tested 7 soil samples are positive for the presence of EPN. Native isolated strains morphologically and molecular identification of nematodes, insect and bacterial sequencing and characterisation of the internal transcribed spacer (ITS) 18S, 12S and 16S region was used to identify all nematode isolates, insects and bacterial strains upto species level (S. feltiae UHF-HR1, H. bacteriophora UHF-HR2; T. absoluta SN1, S. frugiperda SN2; X. bovienii R1, P. luminenscens R2). There have been used as an active biocontrol agent against T. absoluta and S. frugiperda. The bioassay of after 72 hours with different concentrations of 10, 20, 40, 80, and 160 IJs/cm2, the data susceptibility of T. absoluta 4th larval and S. frugiperda 5th instar to infection with the nematode S. feltiae and H. bacteriophora mortality range 74.12 to 90.00 percentage mortalities. To assess the lethal concentration of entomopathogenic nematodes to insect larvae, a toxicity evaluation the LD50 and LD90 for S. feltiae and H. bacteriophora doses in final instar the best larvicidal activity was obtained during the 72-hour exposure period, The susceptibility of infection was found to be greater than 80%. The strains R1 and R2 bacterial isolates were bioassay experiments were X. bovienii and P. luminescens of treatment throughout the investigation, daily larval mortality ranged from 0.00 to 90.00 percent. Our analysis confirmed the steep inclination of S. frugiperda and T. absoluta. S. feltiae UHF-HR1 and H. bacteriophora UHF-HR2 & Photorhabdus and Xenorhabdus were utilised, with 90 percent control over both entomopathogenic nematodes and their symbiotic bacterial strains.
Leaching kinetics of cadmium from rice grain by dilute hydrochloric acid
Authors: Liu Feng , Kai Huang 
Published: July 2022

Abstract
Cadmium-contaminated rice grain was treated by leaching in dilute hydrochloric acid under different conditions, and it was confirmed that cadmium could be effectively extracted to safe standard level of below 0.2mg/kg accompanying with dissolution loss of rice protein at 5 ~ 15% mass. Both the extraction of cadmium and the rice dissolution loss were strongly pH-dependent process. The cadmium leaching kinetic equation was investigated based on the typical core-shrinking model, with apparent activated energy at 16.67KJ/mol suggesting that the intraparticle diffusion of cadmium ion or proton inside of rice grain was the limited step controlling the whole leaching process. Grain size and pH were found the main parameters to affect cadmium extraction efficiency, and pH 1–2 was recommended for rice grain leaching. The acidic solution could be repeatedly used for cadmium extraction by adding an aliquot of HCl before each leaching operation, favorable for the enormous reduction of water consumption.
Mass drug administration campaigns: Comparing two approaches for schistosomiasis and soil-transmitted helminths prevention and control in selected southern Malawi districts
Authors: Makaula Peter , Kayuni Sekeleghe Amos , Mamba Kondwani Chidzammbuyo , Bongololo Grace , Funsanani Mathias , Juziwelo Lazarus Tito , Musaya Janelisa , Furu Peter 
Published: July 2022

Abstract
Background: Mass drug administration (MDA) is one of the key interventions recommended by WHO to control neglected tropical diseases. In Malawi, health workers distribute anti-helminthic drugs annually with most support from donors. The mean community coverage of MDA from 2018 to 2020 were high at 87% for praziquantel and 82% for albendazole, however posing a sustainability challenge once donor support diminishes.Methods: This was a cross-sectional study carried out in three districts, where four health centres and 16 villages were randomly selected and allocated to intervention and control arms. A mixed methods approach to data collection focusing on quantitative data for coverage and knowledge, attitudes and practices; and qualitative data for assessing perceptions of health providers and beneficiaries were used during baseline and follow-up assessments. Quantitative and qualitative data were analyzed using IBM SPSS software version 26 and NVivo 12 for Windows respectively.Results: At follow-up, knowledge levels were high for what schistosomiasis is (65% - 88%) and what STH are (32% - 83%); and low for what causes schistosomiasis (32% - 58%), causes of STH (7% - 37%), intermediate organisms for schistosomiasis (13% - 33%) and types of schistosomiasis (2% - 26%) for both intervention and control arms. Increases in praziquantel coverage were registered in control (86% to 89%) and intervention communities (83% to 89%); decreases were recorded for control (86% to 53%) and intervention schools (79% to 59%). Costs for implementation of the study indicated that most resources were used at community (51%), health centre (29%) and district levels (19%). The intervention arm used more resources at health centre (27%) and community levels (44%) than the control arm. Health workers and community members perceived the use of the CDI approach as a good initiative and more favorable over the standard practice of delivering MDA.Conclusions: The use of the CDI in delivery of MDA campaigns against schistosomiasis and STH is feasible, increases coverage and is acceptable in intervention communities. This could be a way forward addressing the sustainability concern when donor support wanes.Trial Registration: PACTR202102477794401
Transcriptomic study of the cell death-related pathways of cervical cancer HeLa cells in response to Clinacanthus nutans treatment
Authors: Adum Kristine Sandra Pey , Haron Nor Hasyimah binti , Toha Zaleha binti , Arsad Hasni bin 
Published: July 2022

Abstract
Background: Recent years have witnessed major development of novel therapeutic agents like chemotherapy, targeted therapy and immune checkpoint inhibitors for cervical cancer. However, cervical cancer remains prevalent, leading to a large number of deaths worldwide. A better understanding of the cervical cancer biology and signaling pathways might lead to the development of targeted therapies in reducing the incidence and mortality rate. Methods: In this study, the RNA-Seq reads of HeLa cells treated with C. nutans were compared to the untreated sample. The reads of these two sample groups were firstly aligned to the human reference genome. The results in BAM files format that were generated were then sorted before being assembled. The output of assembly which was in coverage table form was ready for downstream statistical analyses for differential expression. Differentially expressed genes were obtained and the cell-death related pathway were identified by canonical pathway, QIAGEN Ingenuity Pathway Analysis (IPA). The verification of significant genes was carried out using qRT-PCR by including GAPDH as a housekeeping gene Results: With this, we identified a total of 668 upregulated and 479 downregulated analysis-ready genes across observations upon cut-off setting log2FoldChange at 0.5 and P-value 0.05. A total of 28 cell-death related canonical pathways and 4 activation of cell-death related functions were identified. Upon analyses, we identified four significant genes (Casp9, KAI1, REL and FOXO4) that hold important role in promoting cell death. These findings were also verified against the quantification using qRT-PCR by including GAPDH as a housekeeping gene. Conclusions: This study provides an insight on the potential role of DCM fraction of C. nutans in activating Casp9, KAI1, REL and FOXO4 genes in mediating apoptosis in cervical cancer cells.
Researching, Co-creating and Testing Innovations in Paper Health Information Systems (PHISICC) to Support Health Workers Decision-making: Protocol of a Multi-country, Transdisciplinary, Mixed-methods Research Programme in Three Sub-saharan Countries
Authors: Bosch-Capblanch Xavier , O’Donnell David , Krause L Kendall , Auer Christian , Oyo-Ita Angela , Samba Mamadou , Matsinhe Graça , Garba Abdullahi Bulama , Rodríguez Damaris , Zuske Meike , Njepuome Anthonia Ngozi , Lee Sofia Micael Mandjate , Ross Amanda , Gajewski Suzanne , Muloliwa Artur Manuel , Yapi Richard B , Brown David W 
Published: July 2022

Abstract
BackgroundHealth Information Systems are crucial to provide data for decision-making and data demands are constantly growing. However, the link between data and decisions is not always rational nor linear and the management of data ends up overloading frontline health workers, who may have to compromise the health care. Despite limited evidence, there is an increasing push for the digitalisation of Health Information Systems, which faces enormous challenges, particularly in remote, rural settings in low- and middle-income countries. Paper-based tools will continue to be used and this warrants efforts to make them more responsive to local needs. Paper Health Information Systems (PHISICC) is a transdisciplinary, multi-country research initiative to create and test innovative paper-based Health Information Systems in three Sub-Saharan African countries.MethodsThe PHISICC initiative is taking place in remote, rural settings, in Côte d’Ivoire, Mozambique and Nigeria, through partnership with Ministries of Health and research institutions. We began with research syntheses to acquire the most up to date knowledge on Health Information Systems. These were coupled with field work in the three countries to understand the current design, patterns and contexts of use, and health care worker perspectives. Frontline health workers, with designers and researchers, used co-creation methods to produce the new PHISICC tools. This suite of tools is being tested in the three countries. Throughout the project, we have engaged with a wide range of stakeholders and have kept the highest scientific standards to keep it relevant to health policy in each of the three countries.DiscussionWe have deployed a comprehensive research approach to ensure the robustness and future policy uptake of the finding. Beyond the resulting paper-based tool design innovations, our process itself was innovative. Rather than emphasizing the data management compliance aspects we focused instead on frontline health workers’ decision-making; by tackling the whole scope of health care areas in Primary Health Care rather than incremental improvement to existing tools, we developed an entirely new design approach and language for a suite of tools in Primary Health Care. The initiative is being tested in remote, rural areas where the most vulnerable live.
Roton pair density wave and unconventional strong-coupling superconductivity in a topological kagome metal
Authors: Gao Hong-Jun , Chen Hui , Yang Haitao , Hu Bin , Zhao Zhen , Yuan Jie , Xing Yuqing , Qian Guojian , Huang Zihao , Li Geng , Ye Yuhan , Ma Sheng , Ni Shunli , Zhang Hua , Yin Qiangwei , Gong Chunsheng , Tu Zhijun , Lei Hechang , Tan Hengxin , Zhou Sen , Shen Chengmin , Dong Xiaoli , Yan Binghai , Wang Ziqiang 
Published: July 2022

Abstract
The recently discovered family of vanadium-based kagome metals with topological band structures offer new opportunities to study frustrated, correlated topological quantum states. These layered compounds are nonmagnetic and undergo charge density wave (CDW) transitions before developing superconductivity at low temperatures. Here we report the observation of unconventional superconductivity and pair density wave (PDW) in the vanadium-based kagome metal CsV3Sb5 using scanning tunneling microscope/spectroscopy (STM/STS) and Josephson STS. The differential conductance exhibits a V-shaped pairing gap Δ~0.5 meV below a transition temperature Tc~2.3 K. Superconducting phase coherence is observed by Josephson effect and Cooper-pair tunneling using a superconducting tip. We find that CsV3Sb5 is a strong-coupling superconductor (2∆/kBTc~5) and coexists with long-range 4a0 unidirectional and 2×2 charge order. Remarkably, we discover a bidirectional PDW accompanied by 4a0/3 spatial modulations of the coherence peak and gap-depth in the tunneling conductance. We term this novel quantum state a roton-PDW that can produce a commensurate vortex-antivortex lattice and account for the observed conductance modulations. Above Tc, we observe a large V-shaped pseudogap in the 4a0 unidirectional and 2a0 bidirectional CDW state. Electron-phonon calculations attribute the 2×2 CDW to phonon softening induced structural reconstruction, but the phonon mediated pairing cannot describe the observed strong-coupling superconductor. Our findings show that electron correlations drive the 4a0 unidirectional CDW, unconventional superconductivity, and roton-PDW with striking analogies and distinctions to the phenomenology of high-Tc cuprate superconductors, and provide groundwork for understanding their microscopic origins in vanadium-based kagome superconductors.
Hydroxylamine-enhanced Fe(II)-peroxymonosulfate activation for efficient degradation of organic pollutants: optimization by response surface methodology
Authors: Zhang Kuo , Zhang Ming , Zhou Runjuan , Zhou Ting 
Published: July 2022

Abstract
In this work, the response surface methodology (RSM) was used to model and optimize the hydroxylamine (HA) enhanced Fe(II)/peroxymonosulfate (PMS) process. The enhanced effect of HA on the degradation efficiency of Orange II (AO7) in the Fe(II)/PMS system was quantitatively analyzed. Pareto analysis showed that the individual and interactive effects of HA, Fe(II) and PMS were of the following order: HA &gt; Fe(II) &gt; PMS and Fe(II)/PMS &gt; HA/PMS &gt; Fe(II)/HA. The optimal conditions of HA/Fe(II)/PMS system were as follows: Fe(II) concentration was 34.0 μM, HA concentration was 0.4 mM, and PMS concentration was 0.9 mM. When the initial pH was 4.0–6.0, the degradation efficiency of AO7 in the HA/Fe(II)/PMS system was significantly higher than that in the Fe(II)/PMS system (P &lt; 0.05). Hydroxylamine enhances the degradation of AO7 in the Fe(II)/PMS system by reducing Fe(III) to Fe(II). The results of quenching experiment showed that SO4•− was the dominating reactive oxygen species (ROS) in the HA/Fe(II)/PMS system. In the HA/Fe(II)/PMS system, CO32− and humic acid inhibited the degradation efficiency of AO7. This work provides a novel mathematical model for the degradation of AO7 in the HA/Fe(II)/PMS system, which can be popularized and applied in similar experiments.
The Data-Adaptive Fellegi-Sunter Model for Probabilistic Record Linkage: Algorithm Development and Validation for Incorporating Missing Data and Field Selection
Authors: Li Xiaochun , Xu Huiping , Grannis Shaun 
Published: July 2022

Background
Quality patient care requires comprehensive health care data from a broad set of sources. However, missing data in medical records and matching field selection are 2 real-world challenges in patient-record linkage.

Objective
In this study, we aimed to evaluate the extent to which incorporating the missing at random (MAR)–assumption in the Fellegi-Sunter model and using data-driven selected fields improve patient-matching accuracy using real-world use cases.

Methods
We adapted the Fellegi-Sunter model to accommodate missing data using the MAR assumption and compared the adaptation to the common strategy of treating missing values as disagreement with matching fields specified by experts or selected by data-driven methods. We used 4 use cases, each containing a random sample of record pairs with match statuses ascertained by manual reviews. Use cases included health information exchange (HIE) record deduplication, linkage of public health registry records to HIE, linkage of Social Security Death Master File records to HIE, and deduplication of newborn screening records, which represent real-world clinical and public health scenarios. Matching performance was evaluated using the sensitivity, specificity, positive predictive value, negative predictive value, and F1-score.

Results
Incorporating the MAR assumption in the Fellegi-Sunter model maintained or improved F1-scores, regardless of whether matching fields were expert-specified or selected by data-driven methods. Combining the MAR assumption and data-driven fields optimized the F1-scores in the 4 use cases.

Conclusions
MAR is a reasonable assumption in real-world record linkage applications: it maintains or improves F1-scores regardless of whether matching fields are expert-specified or data-driven. Data-driven selection of fields coupled with MAR achieves the best overall performance, which can be especially useful in privacy-preserving record linkage.
Initial Psychometric Properties of 7 NeuroUX Remote Ecological Momentary Cognitive Tests Among People With Bipolar Disorder: Validation Study
Authors: Moore Raeanne C , Parrish Emma M , Van Patten Ryan , Paolillo Emily , Filip Tess F , Bomyea Jessica , Lomas Derek , Twamley Elizabeth W , Eyler Lisa T , Depp Colin A 
Published: July 2022

Background
As smartphone technology has become nearly ubiquitous, there is a growing body of literature suggesting that ecological momentary cognitive testing (EMCT) offers advantages over traditional pen-and-paper psychological assessment. We introduce a newly developed platform for the self-administration of cognitive tests in ecologically valid ways.

Objective
The aim of this study is to develop a Health Insurance Portability and Accountability Act–compliant EMCT smartphone-based platform for the frequent and repeated testing of cognitive abilities in everyday life. This study examines the psychometric properties of 7 mobile cognitive tests covering domains of processing speed, visual working memory, recognition memory, and response inhibition within our platform among persons with and without bipolar disorder (BD). Ultimately, if shown to have adequate psychometric properties, EMCTs may be useful in research on BD and other neurological and psychiatric illnesses.

Methods
A total of 45 persons with BD and 21 demographically comparable healthy volunteer participants (aged 18-65 years) completed smartphone-based EMCTs 3 times daily for 14 days. Each EMCT session lasted approximately 1.5 minutes. Only 2 to 3 tests were administered in any given session, no test was administered more than once per day, and alternate test versions were administered in each session.

Results
The mean adherence to the EMCT protocol was 69.7% (SD 20.5%), resulting in 3965 valid and complete tests across the full sample. Participants were significantly more likely to miss tests on later versus earlier study days. Adherence did not differ by diagnostic status, suggesting that BD does not interfere with EMCT participation. In most tests, age and education were related to EMCT performance in expected directions. The average performances on most EMCTs were moderately to strongly correlated with the National Institutes of Health Toolbox Cognition Battery. Practice effects were observed in 5 tests, with significant differences in practice effects by BD status in 3 tests.

Conclusions
Although additional reliability and validity data are needed, this study provides initial psychometric support for EMCTs in the assessment of cognitive performance in real-world contexts in BD.
Randomized Controlled Trials of Artificial Intelligence in Clinical Practice: Systematic Review
Authors: Lam Thomas Y T , Cheung Max F K , Munro Yasmin L , Lim Kong Meng , Shung Dennis , Sung Joseph J Y 
Published: July 2022

Background
The number of artificial intelligence (AI) studies in medicine has exponentially increased recently. However, there is no clear quantification of the clinical benefits of implementing AI-assisted tools in patient care.

Objective
This study aims to systematically review all published randomized controlled trials (RCTs) of AI-assisted tools to characterize their performance in clinical practice.

Methods
CINAHL, Cochrane Central, Embase, MEDLINE, and PubMed were searched to identify relevant RCTs published up to July 2021 and comparing the performance of AI-assisted tools with conventional clinical management without AI assistance. We evaluated the primary end points of each study to determine their clinical relevance. This systematic review was conducted following the updated PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines.

Results
Among the 11,839 articles retrieved, only 39 (0.33%) RCTs were included. These RCTs were conducted in an approximately equal distribution from North America, Europe, and Asia. AI-assisted tools were implemented in 13 different clinical specialties. Most RCTs were published in the field of gastroenterology, with 15 studies on AI-assisted endoscopy. Most RCTs studied biosignal-based AI-assisted tools, and a minority of RCTs studied AI-assisted tools drawn from clinical data. In 77% (30/39) of the RCTs, AI-assisted interventions outperformed usual clinical care, and clinically relevant outcomes improved with AI-assisted intervention in 70% (21/30) of the studies. Small sample size and single-center design limited the generalizability of these studies.

Conclusions
There is growing evidence supporting the implementation of AI-assisted tools in daily clinical practice; however, the number of available RCTs is limited and heterogeneous. More RCTs of AI-assisted tools integrated into clinical practice are needed to advance the role of AI in medicine.

Trial Registration
PROSPERO CRD42021286539; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=286539
The Determination of Downhole Dynamic Compaction Paramaters Based on Finite Element Analysis
Authors: Wijaya Martin , Arsyad Ahmad Kemal , Lim Aswin , Rahardjo Paulus Pramono 
Published: July 2022

Downhole dynamic compaction (DDC) has been commonly used in China to stabilize collapsible soil through the application of construction and demolition waste material (CDW). DDC basically forms a column inside the soil stratum which is similar to a stone column except DDC materials are put in sequence and then compacted by using DDC hammer. Due to its attractive features such as its big diameter, feasibility of using oversized material particles, rapid and simple construction technique, it is used as one of the ground improvement methods for an airport project in Indonesia. Despite of all the advantages provided by DDC, it is difficult to obtain DDC parameters from laboratory tests as it is difficult to replicate the compaction effort induced by the DDC hammer and laboratory tests are not commonly employed for oversized materials. Hence, alternative method is required to evaluate DDC parameters. In this study, static load test is conducted to determine load-deformation curve of the DDC pile. Soil parameters are first determined through soil test data such as standard penetration test (SPT), laboratory test and also pressure meter tests. Correlation between pressure meter tests and SPT test result is also carried in order to interpret the soil parameter at the site. Axisymmetric finite element analysis is then carried by using MIDAS GTS NX in order to back analyses DDC parameters by matching the simulation curve with load settlement curve of the DDC. In this paper, it is shown that back analysis using hardening soil model for DDC material can be used to match simulation curve with the load-deformation curve.