bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of social media and brand equity on business-to-business marketing
Authors: Fagundes Ligia , Gomes-e-Souza Munaier Christian , Crescitelli Edson 
Published: April 2022

PurposeBrand equity (BE) can be strengthened by the strategic association of brand heritage (BH) with social media (SM) in business-to-business (B2B) markets.Design/methodology/approachQualitative research using cognitive maps.FindingsBH empowers BE and should be explored within B2B communications.Research limitations/implicationsBrand image and other BH dimensions should be measured in next studies.Practical implicationsBH strongly influences SM, especially the fan loyalty, and impacts BE in all dimensions.Social implicationsResearch shows marketing mix impacted, BE reinforcement and willingness to pay a premium price.Originality/valueInteraction between BH, SM and BE in B2B has not been evaluated yet.
Role of sleep quality in the acceleration of biological aging and its potential for preventive interaction on air pollution insults: Findings from the UK Biobank cohort
Authors: Gao Xu , Huang Ninghao , Guo Xinbiao , Huang Tao 
Published: April 2022

AbstractSleep has been associated with aging and relevant health outcomes, but the causal relationship remains inconclusive. In this study, we investigated the associations of sleep behaviors with biological ages (BAs) among 363,886 middle and elderly adults from UK Biobank. Sleep index (0 [worst]–6 [best]) of each participant was retrieved from the following six sleep behaviors: snoring, chronotype, daytime sleepiness, sleep duration, insomnia, and difficulties in getting up. Two BAs, the KDM‐biological age and PhenoAge, were estimated by corresponding algorithms based on clinical traits, and their residual discrepancies with chronological age were defined as the age accelerations (AAs). We first observed negative associations between the sleep index and the two AAs, and demonstrated that the change of AAs could be the consequence of sleep quality using Mendelian randomization with genetic risk scores of sleep index and BAs. Particularly, a one‐unit increase in sleep index was associated with 0.104‐ and 0.119‐year decreases in KDM‐biological AA and PhenoAge acceleration, respectively. Air pollution is another key driver of aging. We further observed significant independent and joint effects of sleep and air pollution (PM2.5 and NO2) on AAs. Sleep quality also showed a modifying effect on the associations of elevated PM2.5 and NO2 levels with accelerated AAs. For instance, an interquartile range increase in PM2.5 level was associated with 0.009‐, 0.044‐, and 0.074‐year increase in PhenoAge acceleration among people with high (5–6), medium (3–4), and low (0–2) sleep index, respectively. Our findings elucidate that better sleep quality could lessen accelerated biological aging resulting from air pollution.
Modal clustering on PPGMMGA projection subspace
Authors: Scrucca Luca 
Published: April 2022

SummaryPPGMMGA is a projection pursuit (PP) algorithm aimed at detecting and visualising clustering structures in multivariate data. The algorithm uses the negentropy as PP index obtained by fitting Gaussian mixture models (GMMs) for density estimation and, then, exploits genetic algorithms (GAs) for its optimisation. Since the PPGMMGA algorithm is a dimension reduction technique specifically introduced for visualisation purposes, cluster memberships are not explicitly provided. In this paper a modal clustering approach is proposed for estimating clusters of projected data points. In particular, a modal EM algorithm is employed to estimate the modes corresponding to the local maxima in the projection subspace of the underlying density estimated using parsimonious GMMs. Data points are then clustered according to the domain of attraction of the identified modes. Simulated and real data are discussed to illustrate the proposed method and evaluate the clustering performance.
Mindfulness, psychological distress, and somatic symptoms among women engaged in sex work in China
Authors: Tam Cheuk Chi , Zhou Yuejiao , Qiao Shan , Li Xiaoming , Shen Zhiyong 
Published: April 2022

AbstractWomen engaged in sex work (WSW) in China encounter numerous disadvantages (e.g., exposure to violence) and have substantial risk for psychological distress and somatic symptoms. Intervention literature has attended to mindfulness, which is a protective factor for psychological outcomes, and its influences can further improve physical health. However, mindfulness has not been well studied in WSW. We aimed to examine the association among mindfulness, psychological distress, and somatic symptoms among Chinese WSW. Data were collected from 410 WSW in Guangxi, China, using an anonymous, self‐administered survey evaluating demographics, mindfulness, psychological distress (i.e., depression, loneliness, and perceived stress), and somatic symptoms (i.e., pain, cardiopulmonary, and gastrointestinal/fatigue symptoms). Structural equation modeling was utilized for data analyses. Mindfulness was negatively associated with psychological distress and somatic symptoms. Psychological distress was positively associated with somatic symptoms. Psychological distress mediated the association between mindfulness and somatic symptoms. Mindfulness appears to be a protective factor for psychological distress among WSW, and such an effect is further influential to their somatic symptoms. Our findings add to the growing literature on mindfulness, suggesting that mindfulness‐based interventions could be beneficial for WSW. Future research should explore other cognitive factors underlying the psychosomatic mechanism of mindfulness.
Early seed dynamics and tidal marsh revegetation of a salt pond following tidal reconnection
Authors: Beaumont Kieren P. , Dittmann Sabine 
Published: April 2022

AbstractQuestion(1) Following reconnection, does ground cover in the pond become similar to mature salt marsh sites over time? (2) Do seed densities and species composition of seed banks and seed rain differ between the pond and mature salt marsh, and between elevations? (3) Do seed densities vary over time? (4) Within the pond, can seed densities be explained by the abundance of reproductive plants, elevation, or distance from the pond inlet.LocationDry Creek salt field, South Australia.MethodsWe sampled seed rain (monthly) and seed banks (every three months) 6 to 18 months after tidal reconnection and surveyed ground cover (plant species, logs, seagrass wrack and bare ground) up to 34 months after reconnection. Samples were collected from the pond and from mature marsh vegetation at a reference site, and a site immediately adjacent to the pond inlet.ResultsVegetation cover in the pond increased more quickly at mid elevations compared with low elevations. Regarding the composition of ground cover, seed rain and seed banks, the site became more similar to the adjacent site than to the reference site. Seed densities increased from late autumn to early winter. The pattern of seed densities across sites and elevations differed between seed rain and seed banks. Seeds of Salicornia quinqueflora and Suaeda australis dominated in the pond, reflecting their high seed densities adjacent to the pond inlet. Variation in seed densities of both species in the pond was explained by the abundance of nearby, reproductive conspecifics but not by the distance from the inlet.ConclusionsEarly stages of salt marsh revegetation were driven by tidal import of seeds and by the rapid seed production of early colonising species; however, low seed densities may reduce rates of revegetation at low elevations. Seed dispersal and revegetation may be maximised by undertaking tidal reconnection when seed densities are highest.
Endocapsular artificial iris implantation for iris defects: Reducing symptoms, restoring visual function and improving cosmesis
Authors: Crawford Alexandra Z. , Freundlich Simone E. N. , Lim Joevy , McGhee Charles N. J. 
Published: April 2022

AbstractBackgroundTo investigate repair of iris defects by endocapsular implantation of an artificial iris, in relation to visual outcomes, safety profile and patient satisfaction.MethodsRetrospective, consecutive case series from Greenlane tertiary teaching hospital and Eye Institute, Auckland, New Zealand. Medical records of patients implanted with an endocapsular artificial iris were reviewed and followed for minimum 3 months. Patient characteristics, surgical management, clinical outcomes and subjective responses were recorded.ResultsNineteen artificial irises were implanted in 18 patients. Etiologies were iris melanotic lesion excision (73.7%), trauma (10.5%), congenital aniridia (10.5%) and Urrets‐Zavalia syndrome (5.3%). During postoperative follow‐up [14.1 ± 12.4 months (range: 3 to 59 months)], best corrected visual acuity (BCVA) and intraocular pressure (IOP) did not change significantly [BCVA, 0.23 logarithm of the minimum angle of resolution (logMAR) (20/32 Snellen) preoperatively vs. 0.18 logMAR postoperatively (20/25 Snellen) (Z = −0.222, p = 0.824); IOP, 15 mmHg preoperatively vs. 17 mmHg postoperatively (Z = 1.377, p = 0.1447)]. Mild or self‐limiting complications included: elevated IOP (42.1%), cystoid macular oedema (15.8%); persisting postoperative uveitis (15.8%) and minor vaulting of the prosthesis (15.7%). Moderate or severe complications included significant vaulting of prosthesis requiring surgical revision (5.3%) and a single eye (5.3%) with trabeculectomy and corneal graft failure. 94.4% of patients were very satisfied with the cosmesis and would be highly likely to have the procedure again.ConclusionsThis study confirms that endocapsular insertion of an artificial iris is typically associated with good functional and cosmetic results and a relatively low risk of significant complications.
Targeting AKT and CK2 represents a novel therapeutic strategy for SMO constitutive activation‐driven medulloblastoma
Authors: Yao Yue‐Liang , Wang Yan‐Xia , Yang Fei‐Cheng , Wang Chuan , Mao Min , Gai Qu‐Jing , He Jiang , Qin Yan , Yao Xiao‐Xue , Lan Xi , Zhu Jiang , Lu Hui‐Min , Zeng Hui , Yao Xiao‐Hong , Bian Xiu‐Wu , Wang Yan 
Published: April 2022

AbstractAimsSonic hedgehog subtype medulloblastoma is featured with overactivation of hedgehog pathway and can be targeted by SMO‐specific inhibitors. However, the resistance is frequently developed leading to treatment failure of SMO inhibitors. W535L mutation of SMO (SMOW535L) is thought to be an oncogenic driver for Sonic hedgehog subtype MB and confer resistance to SMO inhibitors. The regulation network of SMOW535L remains to be explored in comparison with wild‐type SMO (SMOWT).MethodsIn this study, we profiled transcriptomes, methylomes, and interactomes of MB cells expression SMOWT or SMOW535L in the treatment of DMSO or SMO inhibitor, respectively.ResultsAnalysis of transcriptomic data indicated that SMO inhibitor disrupted processes of endocytosis and cilium organization in MB cells with SMOWT, which are necessary for SMO activation. In MB cells with SMOW535L, however, SMO inhibitor did not affect the two processes‐related genes, implying resistance of SMOW535L toward SMO inhibitor. Moreover, we noticed that SMO inhibitor significantly inhibited metabolism‐related pathways. Our metabolic analysis indicated that nicotinate and nicotinamide metabolism, glycerolipid metabolism, beta‐alanine metabolism, and synthesis and degradation of ketone bodies might be involved in SMOW535L function maintenance. Interactomic analysis revealed casein kinase II (CK2) as an important SMO‐associated protein. Finally, we linked CK2 and AKT together and found combination of inhibitors targeting CK2 and AKT showed synergetic effects to inhibit the growth of MB cells with SMO constitutive activation mutation.ConclusionsTaken together, our work described SMO‐related transcriptomes, metabolomes, and interactomes under different SMO status and treatment conditions, identifying CK2 and AKT as therapeutic targets for SHH‐subtype MB cells with SMO inhibitor resistance.
Effect of meal intake for evaluating hepatic artery by Doppler ultrasonography in liver transplants: Does fasting matter for screening hepatic artery due to hemodynamic changes in splanchnic circulation?
Authors: Ulu Öztürk Funda , Tezcan Şehnaz , Ayvazoğlu Soy Ebru Hatice , Uslu Nihal , Haberal Mehmet 
Published: April 2022

AbstractPurposeThe aim of this study is to assess the utility of fasting on Doppler ultrasonography findings of hepatic artery in liver transplants.MethodsLiver transplant patients without vascular abnormalities were prospectively evaluated between December 2017 and January 2020. Doppler sonography was used to describe hemodynamic changes in response to a standard meal. The diameter, peak systolic velocity, blood flow, resistive index (RI) of the main hepatic artery and portal vein peak velocity were measured.ResultsThe mean hepatic arterial diameter of 44 patients was higher in the fasting group (4.5 mm) than in the postprandial group (3.3 mm) (p < .05). The mean hepatic arterial blood flow decreased (from .276 to .127 L/min) and hepatic arterial RI increased (from .66 to .71) following meal ingestion (p < .05). Hepatic arterial velocity was significantly lower and portal venous velocity was higher after oral intake.ConclusionMeal ingestion has an important effect on hepatic artery Doppler features in liver transplants. Therefore, Doppler ultrasound evaluation should be considered after appropriate fasting due to postprandial responses of liver transplant.
Big data, artificial intelligence and machine learning: A transformative symbiosis in favour of financial technology
Authors: Nguyen Duc Khuong , Sermpinis Georgios , Stasinakis Charalampos 
Published: April 2022

AbstractThis paper uses a multidimensional descriptive analysis to familiarize the reader with the extent of penetration of big data, artificial intelligence (AI) and machine learning (ML) techniques in the financial technology roadmap. We propose a clear framework for the symbiotic nature of these data science themes towards fintech empowerment. The framework is validated through their impact on fintech, financial services' profession and the shifting paradigm of the data scientist role. We also discuss the dark side of this symbiosis, while AI and ML techniques are tied with the future challenges of AI ethics, regulation technology and the smart data utilization.
Most subjectively affected joints in patients with haemophilia – what has changed after 20 years in Germany?
Authors: Hmida Jamil , Hilberg Thomas , Ransmann Pia , Tomschi Fabian , Klein Claudia , Koob Sebastian , Franz Alexander , Richter Heinrich , Oldenburg Johannes , Strauss Andreas C. 
Published: April 2022

AbstractBackgroundIn patients with haemophilia (PwH), most frequently affected joints are the ankle, knee and elbow. Due to improved factor therapy in the last decades, these previous findings have to be verified in Germany.AimThe aim of this study is to detect the most affected joint, evaluate the significance of the source of pain and determine the point prevalence of back pain in Germany today.Patients and methodsIn a retrospective study, data of n = 300 patients with severe moderate and mild haemophilia were evaluated regarding the most affected joint, the most common source of pain, and the point prevalence of back pain. An anamnesis questionnaire and the German Pain Questionnaire were used for this assessment.ResultsThe most affected joint in German PwH is still the ankle (41%), followed by the knee (27%) and the elbow (11%). The most common source of pain is also the ankle joint (32%). Back pain was also identified as one of the most common sources of pain, which is comparable to the elbow (elbow:15%; back:13%). The point prevalence in PwH for back pain was significantly higher compared to the general German population (P = .031).ConclusionOur data showed that the ankle is still the most affected joint and the most common source of pain in Germany. These results also showed the relevance of back pain as a pain source. The evaluations also demonstrated the high point prevalence of back pain in PwH. Future therapies should also focus on the spine because joint changes affect posture.
Prior oral proton‐pump inhibitor use is associated with reduced severity of aspirin‐related upper gastrointestinal bleeding in older people
Authors: Ayonrinde Oyekoya T. , Walldorf Natasha , Chan Nicholas , Foo Nathanael Y. , Kulkarni Tithi , Olynyk John K. , Sanfilippo Frank M. 
Published: April 2022

AbstractLow‐dose aspirin is commonly used for primary or secondary prophylaxis against cardiovascular disease in older people. However, the potential risk of upper gastrointestinal (UGI) ulceration and bleeding associated with low‐dose aspirin use is often not appreciated by prescribers and older consumers. Among 133 serial patients with UGI bleeding, aspirin‐users aged ≥70 years had a ninefold increased likelihood of overt UGI bleeding compared with non‐users, reducing by 90% in regular proton‐pump inhibitor users (adjusted odds ratio 0.10). We recommend risk‐versus‐benefit discussions when recommending aspirin to older people.
HIV: the changing paradigm
Authors: Raubinger Sian , Lee Frederick J. , Pinto Angie N. 
Published: April 2022

AbstractThe past four decades have seen enormous progress in the diagnosis and management of human immunodeficiency virus (HIV) infection. There have been significant advances spanning the approval of the first antiretroviral agents, the advent of combination antiretroviral therapy to single tablet regimens with minimal toxicity. Although these remarkable developments have on the surface led to the ‘end of AIDS’, there are still key populations being left behind. This clinical update will describe the diagnosis and management of HIV, and the changing paradigms that have seen HIV transform from a life‐limiting condition to a manageable chronic disease over a few decades.
The hybrid convergent procedure for persistent and long‐standing persistent atrial fibrillation from an electrophysiologist's perspective
Authors: DeLurgio David B. 
Published: April 2022

AbstractIn atrial fibrillation (AF), the pulmonary veins (PVs) are central to arrhythmogenicity and are targeted by PV isolation (PVI). As AF progresses, triggers become more prevalent in non‐PV areas including the left atrial posterior wall (LAPW). Reported benefits of LAPW isolation in Cox‐maze IV led to exploration of ablation strategies using endocardial catheters. However, no single approach to endocardial LAPW isolation exists. Relative success in comparison to PVI alone has been mixed. The hybrid convergent procedure was developed to combine minimally invasive surgical and electrophysiology techniques to accomplish effective PVI and LAPW isolation. Epicardial LAPW isolation is performed by a cardiothoracic surgeon followed by endocardial ablation by an electrophysiologist who ensures PVI completion and targets any remaining gaps. Safety and effectiveness of hybrid convergent were evaluated in the prospective, multicenter, randomized controlled trial, Convergence of Epicardial and Endocardial Ablation for the Treatment of Symptomatic Persistent AF (CONVERGE). CONVERGE compared the effectiveness of the hybrid convergent procedure to endocardial catheter ablation for treatment of drug‐refractory persistent and long‐standing persistent AF and demonstrated primary effectiveness of higher freedom from atrial arrhythmias absent new/increased dose previously failed/intolerant antiarrhythmic drugs through 12 months compared to endocardial catheter ablation. Greater freedom from AF and proportion of patients experiencing ≥90% burden reduction with hybrid convergent ablation were seen through 18 months of follow‐up. Improved electrophysiology lab efficiency was demonstrated by the reduction in endocardial ablation time with addition of epicardial ablation. This multidisciplinary heart team procedure may improve outcomes in difficult‐to‐treat patients with advanced AF.
Even patients with mild COVID‐19 symptoms after SARS‐CoV‐2 infection show prolonged altered red blood cell morphology and rheological parameters
Authors: Grau Marijke , Ibershoff Lars , Zacher Jonas , Bros Janina , Tomschi Fabian , Diebold Katharina Felicitas , Predel Hans‐Georg , Bloch Wilhelm 
Published: April 2022

AbstractInfection with the novel severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) and the associated coronavirus disease‐19 (COVID‐19) might affect red blood cells (RBC); possibly altering oxygen supply. However, investigations of cell morphology and RBC rheological parameters during a mild disease course are lacking and thus, the aim of the study. Fifty individuals with mild COVID‐19 disease process were tested after the acute phase of SARS‐CoV‐2 infection (37males/13 females), and the data were compared to n = 42 healthy controls (30 males/12 females). Analysis of venous blood samples, taken at rest, revealed a higher percentage of permanently elongated RBC and membrane extensions in COVID‐19 patients. Haematological parameters and haemoglobin concentration, MCH and MCV in particular, were highly altered in COVID‐19. RBC deformability and deformability under an osmotic gradient were significantly reduced in COVID‐19 patients. Higher RBC‐NOS activation was not capable to at least in part counteract these reductions. Impaired RBC deformability might also be related to morphological changes and/or increased oxidative state. RBC aggregation index remained unaffected. However, higher shear rates were necessary to balance the aggregation‐disaggregation in COVID‐19 patients which might be, among others, related to morphological changes. The data suggest prolonged modifications of the RBC system even during a mild COVID‐19 disease course.
Reference point formation: Does the market whisper in the background?
Authors: Wang Tianyang , Schwebach Robert G. , Villupuram Sriram V. 
Published: April 2022

AbstractWell‐established studies in behavioral finance confirm that investors are highly influenced by subjective reference points when making economic decisions. Although the literature examines reference point formation for individual stocks based on observed price sequences, the stocks are often treated without considering market context. We extend this literature by incorporating market price information as background to the behavior experiment, and we consider both prospect theory and anticipation/disappointment‐based utility functions in a combined framework to investigate the impact of market context on reference point formation. Our article provides new evidence and insights for investment practitioners and behavioral researchers.
Policy uncertainty and cash dynamics
Authors: Tut Daniel 
Published: April 2022

AbstractWhy and when do firms deviate from target cash? And why do we observe imperfect adjustment of cash? I postulate and provide evidence that policy uncertainty induces financing frictions and adjustment costs, which decelerate the speed of adjustment (SOA) of cash toward target. I find that the effects of policy uncertainty on SOA are higher for firms that operate below target cash than for firms that operate above target cash. The results suggest that under policy uncertainty shocks, firms deviate from target cash as the expected benefit of deviation is greater than the expected value of approaching the target.
Periodicity of trading activity in foreign exchange markets
Authors: Chen Tao , Chan Kam C. , Chang Haodong 
Published: April 2022

AbstractUsing the high‐frequency exchange rates of 25 global currency pairs, we document a striking clock‐time periodicity in which trading activity surges at the beginning of a minute. Additional analyses indicate that clock‐time spikes are accompanied by a lower level of liquidity. Moreover, we find that time‐clustering trades yield permanent price impacts, are devoted to efficient pricing, and make a significant contribution to price discovery. Finally, we investigate three informed scenarios to ascertain how trades at spikes acquire information beforehand and reflect them in markets. Taken together, our findings reinforce the view in the literature that subminute periodicity emanates from algorithmic trading.