bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community perceptions and acceptability of mass drug administration for the control of neglected tropical diseases in Asia-Pacific countries: A systematic scoping review of qualitative research
Authors: Mitchell Elke , Kelly-Hanku Angela , Krentel Alison , Romani Lucia , Robinson Leanne J. , Vaz Nery Susana , Kaldor John , Steer Andrew C. , Bell Stephen 
Published: March 2022

BackgroundPreventative chemotherapy and mass drug administration have been identified as effective strategies for the prevention, treatment, control and elimination of several NTDs in the Asia-Pacific region. Qualitative research can provide in-depth insight into the social dynamics and processes underlying effective implementation of and adherence to mass drug administration programs. This scoping review examines published qualitative literature to examine factors influencing community perceptions and acceptability of mass drug administration approaches to control NTDs in the Asia-Pacific region.MethodologyTwenty-four peer reviewed published papers reporting qualitative data from community members and stakeholders engaged in the implementation of mass drug administration programs were identified as eligible for inclusion.FindingsThis systematic scoping review presents available data from studies focussing on lymphatic filariasis, soil-transmitted helminths and scabies in eight national settings (India, Indonesia, Philippines, Bangladesh, Laos, American Samoa, Papua New Guinea, Fiji). The review highlights the profoundly social nature of individual, interpersonal and institutional influences on community perceptions of willingness to participate in mass drug administration programs for control of neglected tropical diseases (NTD). Future NTD research and control efforts would benefit from a stronger qualitative social science lens to mass drug administration implementation, a commitment to understanding and addressing the social and structural determinants of NTDs and NTD control in complex settings, and efforts to engage local communities as equal partners and experts in the co-design of mass drug administration and other efforts to prevent, treat, control and eliminate NTDs.ConclusionFor many countries in the Asia-Pacific region, the “low hanging fruit has been picked” in terms of where mass drug administration has worked and transmission has been stopped. The settings that remain–such as remote areas of Fiji and Papua New Guinea, or large, highly populated, multi-cultural urban settings in India and Indonesia–present huge challenges going forward.
Double-antigen sandwich ELISA based on chimeric antigens for detection of antibodies to Trypanosoma cruzi in human sera
Authors: Freitas Natália Erdens Maron , Santos Emily Ferreira , Leony Leonardo Maia , Silva Ângelo Antônio Oliveira , Daltro Ramona Tavares , Vasconcelos Larissa de Carvalho Medrado , Duarte Gabriela Agra , Oliveira da Mota Cristiane , Silva Edimilson Domingos , Celedon Paola Alejandra Fiorani , Zanchin Nilson Ivo Tonin , Santos Fred Luciano Neves 
Published: March 2022

Background
Enzyme-linked immunosorbent assays (ELISA) are generally the chosen test for Chagas disease (CD) diagnosis; however, its performance depends on the antigen preparation adsorbed to the solid phase, which may lead to false-positive results and cross-reactions. The use of chimeric recombinant antigens can overcome this limitation. Four chimeric antigens from Trypanosoma cruzi (IBMP-8.1, IBMP-8.2, IBMP-8.3 and IBMP-8.4) were developed and evaluated in phase I, II and III studies using indirect ELISA as diagnostic platform. However, peroxidase-labeled secondary anti-human IgG antibody, which is employed in indirect ELISAs, limits its use for the detection of species-specific and class-specific antibodies. To overcome this limitation, peroxidase-labeled antigens can be utilized, diagnosing both acute or chronic infection, in a species and immunoglobulin class-independent manner, through the use of a double-antigen sandwich ELISA (DAgS-ELISA). We aimed to evaluate and validate the diagnostic performance of the chimeric antigens IBMP-8.1, IBMP-8.2, IBMP-8.3 and IBMP-8.4 in the DAgS-ELISA platform.

Methodology/Principal findings
DAgS-ELISA was optimized by checkerboard titration. In phase I study, 207 positive and 205 negative samples were evaluated. Cross-reactivity to other infections was also assessed using 68 samples. The selected conditions for the tests utilized 25 ng of antigen per well and the conjugate diluted at 1:2,000 for all molecules. In the phase I study, the areas under the curve of IBMP-8.1, IBMP-8.2, IBMP-8.3 and IBMP-8.4 were 98.7%, 99.5%, 98.6% and 98.8%, respectively. Among the positive samples, IBMP-8.1 antigen classified 53 (25.6%) as false negative, IBMP-8.2, 27 (13%), IBMP-8.3, 24 (11.6%) and IBMP-8.4, 43 (20.8%), giving sensitivities of 74.4%, 87%, 88.4% and 79.2%, respectively. The only antigen that did not reach 100% specificity was IBMP-8.3, with 96.6%. IBMP-8.3 was also the only molecule to show cross-reactivity with HTLV.

Conclusions/Significance
DAgS-ELISA is a promising tool for immunodiagnosis, and despite the high AUC values, the performance of this assay was different from the values obtained by our group when using these antigens in the indirect ELISA, for this reason, improvements are being considered to increase the sensitivity of the DAgS-ELISA.
Internalized stigma in patients with schizophrenia: A hospital-based cross-sectional study from Nepal
Authors: Dhungana Saraswati , Tulachan Pratikchya , Chapagai Manisha , Pant Sagun Ballav , Lama Pratik Yonjan , Upadhyaya Shreeram 
Published: March 2022

Introduction
The aim of this study was to examine the internalized stigma of mental illness in patients with schizophrenia visiting psychiatry outpatient in a tertiary level hospital in Kathmandu, Nepal, and to explore the associated sociodemographic and clinical factors.

Methods
This was a cross-sectional study, where participants were selected by purposive sampling from the outpatient department of psychiatry in Tribhuvan University Teaching Hospital, Kathmandu, Nepal. One hundred and fourteen patients were selected and given the Internalized Stigma of Mental Illness scale to complete to assess the level of stigma. A semi-structured sociodemographic form was used to get information on sociodemographic and clinical factors. Simple descriptive analysis was done followed by multivariate analysis to explore the sociodemographic and clinical correlates of stigma in these patients.

Results
A total of 114 patients were included in the study. Moderate to high levels of internalized stigma was reported in almost 90% of patients with schizophrenia. The subscale with the highest mean score was stereotype endorsement and that with the lowest mean score was stigma resistance. Duration of illness was the only clinical variable associated with stigma while occupation was the only sociodemographic variable related to stigma.

Conclusion
Moderate to high levels of internalized stigma were reported across all subscales of stigma in patients with schizophrenia and the prevalence was high. Further, duration of illness was associated with stigma. Stigma reduction should therefore be a component of the overall management of patients diagnosed with schizophrenia.
Impact of catch-up human papillomavirus vaccination on cervical conization rate in a real-life population in France
Authors: Eliès Antoine , Bonneau Claire , Houzard Sophie , Rouzier Roman , Héquet Delphine 
Published: March 2022

Objective
To evaluate the impact of catch-up human papillomavirus (HPV) vaccination on conization rates in France in a large population-based study.

Methods
We conducted a retrospective real-life cohort study on data collected prospectively by French National Health Insurance. Echantillon généralistes des bénéficiaires (EGB) is a database composed of demographic and health care utilization data for a 1/97th sample of the French population. We extracted data about all women born between 1983 and 1991, corresponding to the catch-up population (vaccination after 14 years old) at the time of implementation of HPV vaccination. The primary outcome was the occurrence of conization (all types of procedures) compared between vaccinated and non-vaccinated women.

Results
The cohort consisted of 42,452 women. Vaccination coverage (at least one dose) was low (9.8%, n = 4,129), but increased with time from vaccine implementation, from 0% in the 1983 cohort to 31% in the 1991 cohort. The conization rate was 1% for the overall population. The risk of conization for women between the ages of 19 and 30 years was reduced in the vaccinated group with a Hazard Ratio (HR) of 0.59 (95% CI[0.39–0.90]; p = 0.043).

Conclusions
With a 10-year follow-up, catch-up HPV vaccination is associated with risk reduction of conization between the ages of 19 and 30.
Assessment of mitochondrial respiratory capacity using minimally invasive and noninvasive techniques in persons with spinal cord injury
Authors: Lai Raymond E. , Holman Matthew E. , Chen Qun , Rivers Jeannie , Lesnefsky Edward J. , Gorgey Ashraf S. 
Published: March 2022

Purpose
Muscle biopsies are the gold standard to assess mitochondrial respiration; however, biopsies are not always a feasible approach in persons with spinal cord injury (SCI). Peripheral blood mononuclear cells (PBMCs) and near-infrared spectroscopy (NIRS) may alternatively be predictive of mitochondrial respiration. The purpose of the study was to evaluate whether mitochondrial respiration of PBMCs and NIRS are predictive of respiration of permeabilized muscle fibers after SCI.

Methods
Twenty-two individuals with chronic complete and incomplete motor SCI between 18–65 years old were recruited to participate in the current trial. Using high-resolution respirometry, mitochondrial respiratory capacity was measured for PBMCs and muscle fibers of the vastus lateralis oxidizing complex I, II, and IV substrates. NIRS was used to assess mitochondrial capacity of the vastus lateralis with serial cuff occlusions and electrical stimulation.

Results
Positive relationships were observed between PBMC and permeabilized muscle fibers for mitochondrial complex IV (r = 0.86, P < 0.0001). Bland-Altman displayed agreement for complex IV (MD = 0.18, LOA = -0.86 to 1.21), between PBMCs and permeabilized muscles fibers. No significant relationships were observed between NIRS mitochondrial capacity and respiration in permeabilized muscle fibers.

Conclusions
This is the first study to explore and support the agreement of less invasive clinical techniques for assessing mitochondrial respiratory capacity in individuals with SCI. The findings will assist in the application of PBMCs as a viable alternative for assessing mitochondrial health in persons with SCI in future clinical studies.
Bellezas centenarias
Authors: Rodriguez Miguel 
Published: March 2022

Entre las múltiples manifestaciones festivas y culturales con las que se conmemoró en 1921 la Consumación de la Independencia en la Ciudad de México, tiene un particular relieve un concurso organizado por el influyente diario El Universal para elegir y coronar una reina de belleza que fuera “auténticamente” indígena. Espectacular aunque controvertido modo de insistir en el componente autóctono de la nación, este Centenario promovía una política subrayadamente populista. El trabajo enfoca cómo, para adecuarse al modelo de feminidad deseado, se van debatiendo a lo largo del año, tanto desde la prensa como en el discurso antropológico dominante, las modalidades del certamen que culmina en el mes de septiembre a través de espectáculos, veladas y desfiles callejeros. El análisis se basa tanto en los preparativos, en los diversos festejos en torno a “la India Bonita” tratados por la prensa, mostrando también cómo la historiografía en los últimos tiempos ha enfocado diversas facetas de este ejemplo de invención de una tradición. Este nueva forma de culto de la belleza femenina, asociada en los veinte a la incorporación de las masas indígenas a la unidad nacional, se ha transformado y sobrevive, como en otros países, con diversos nombres.
Early adoption in an agile online teaching environment
Authors: Hunter Paul , Mullen Helen , Offord Matt , Quinn Nick , Thompson Karen 
Published: March 2022

The Covid-19 pandemic has blown through the Higher Education sector like a Schumpterian ‘gale of creative destruction’ (Schumpeter, 1934), accelerating the pace of change, disrupting entrenched pedagogical approaches, and revealing glimpses of the future of teaching. This study identifies how university-based early adopters responded to this ‘gale,’ successfully implementing the rapid change required to pivot to online teaching while addressing institutional requests to support the reluctant majority. Adopting an innovative interdisciplinary framework, this study advances understanding about the criticality of early-adopter behaviour in implementing change. The triggers, dynamics and impact of early-adopter behaviours are identified, as are the resultant implications for institutions for resourcing, recognising, and rewarding early adopters. The research design is underpinned by polyphony (Belova, 2010). Theoretical aspects from entrepreneurship (Stevenson, Roberts & Grousebeck, 1989) and networked learning (Dohn, Cranmer, Sime, De Laat & Ryberg, 2018) are also incorporated, relating early adopter behaviour to the entrepreneurial process in the context of virtual learning communities. This study uses vignettes from early adopters who have pivoted to online teaching in a university, identifying their experiences of instigating and supporting change. The findings highlight the facilitators of, and constraints on, early adopter behaviour, identifying the contextual characteristics necessary to challenge preconceived institutional notions and develop intrapreneurial mindsets that more readily support and implement early-adopter behaviours.
Critical reflections on academic leadership during Covid-19: Using Complexity Leadership Theory to understand the transition to remote and blended learning
Authors: Howden Stella 
Published: March 2022

This analysis provides a reflective account of leadership by two Associate Deans in a Higher Education Institution during the first wave of Covid-19. It could be argued that adaptable academic leadership has never been more critical than during the global pandemic when major transformations were needed, not just in how higher education (HE) is delivered, but in how staff work and interact. Literature associated with change identifies the significance of context and leadership. Understanding supportive leadership practices that enabled successful change during this time has the potential to influence future leadership. It will also inform ambitions to innovate and enhance remote and blended learning.
The transition to remote and blended learning through the pandemic continues to be important and complex work, aiming to support positive student experiences and learning. Using Complexity Leadership Theory (CLT) (Uhl-Bien & Arena, 2017) as a reflective tool, this analysis considers this transition. CLT allows for exploration within a richly interconnected system that requires continual and flexible changes and adaptations, such as an HE institution. CLT proposes that innovative responses emerge from the tensions between entrepreneurial thinking and operational practice within an enabling environment.
The authors draw from a series of reflective artefacts to deepen understanding of how their academic leadership practices had adapted during the time of a major system shock. These artefacts informed the analysis and included recorded conversations between the authors (March – November 2020), focusing on the experiences and sense-making of leadership and changes in learning and teaching in one HEI. More specifically, the contribution of CLT is explored, proposing the value of this lens in illuminating not just what happened but also how leaders enacted change. The findings offer new perspectives on enabling innovation, leadership, and the implications beyond this crisis.
Academic Development during Pandemic: A Staged Approach
Authors: Boyd Vic , Cunningham Tom , Cunningham Catriona 
Published: March 2022

In considering the impact on Learning and Teaching of the move to Technology Enabled Education (TEE) in response to the pandemic, the University of Stirling commissioned a report to establish priorities for future learning spaces and practices. Reporting in December 2020, the Sustainable Learning and Teaching @ Stirling project reflected on the progress made since March and provided recommendations for future developments. The project made use of a forward-looking approach influenced by Appreciative Inquiry (Cooperrider & Srivastva, 1987) as a method of evaluation based on success, enhancement and progress.
The report highlighted the early adopters at Stirling: an expert core of staff within Academic Development and Learning Technology who designed, created and delivered a coherent programme of staff development activities and resources (Supporting Online Learning and Teaching at Stirling - SOLT) to support colleagues in developing or re-developing learning and teaching materials for Autumn 2020. This core also created and cultivated new communities of practice: Faculty Champions (academic staff) to share best practice, and Students as Partners in Learning to provide meaningful feedback to staff on online modules prior to the semester starting.
This paper looks forward from the report: exploring the impact, challenges and opportunities for academic developers and considering in particular what a possible narrative of ‘Stirlingness’ might look like. We are often there – on the sidelines (Green & Little, 2013) - working with others to shape a community of practice in supporting learning and teaching but what is our narrative in all of this? As two academic developers who shaped and developed the institutional approach described here, we will draw on the method of ‘dialogic play script form’ (Wyatt & Gale, 2018) to explore our own perspectives on the sudden and transformative enhancement process we have experienced this year. We aim to show future opportunities for academic development, with potential value in and for the changing role of the academic developer (Bamber, 2020).
Kennzahlenbasiertes F & E-Controlling im Kontext der Elektromobilität
Authors: Mayr Andreas , Rommel Christian , Schaller Veronika , Franke Jörg 
Published: March 2022

Abstract
Die deutsche Automobilindustrie steht angesichts der Elektromobilität vor einem radikalen Wandel. Um ihre Technologieführerschaft beizubehalten, stehen die F & E-Abteilungen der etablierten Akteure unter hohem Druck. Im Rahmen dieses Beitrags wird gezeigt, wie sich ein passgenaues Kennzahlengerüst für das Controlling des operativen F & E-Prozesses erarbeiten lässt. Die Validierung der vorgestellten Methode erfolgt anhand eines Maschinen- und Anlagenbauers im Bereich der Elektromobilität, der GROB-WERKE GmbH & Co. KG in Mindelheim.
Elemente der „Fabrik der Zukunft“
Authors: Schäfer Simon F. , Gorke Nils T. , Cevirgen Cihan , Park Yeong-Bae , Nyhuis Peter 
Published: March 2022

Abstract
Die Anforderungen an zukünftige Fabriken wachsen im Zuge der immer komplexeren Vernetzung von Wertschöpfungsprozessen stetig. Dieser erhöhte Druck erfordert eine digitale Transparenz, um mit den gesteigerten Herausforderungen, insbesondere im Zielfeld Nachhaltigkeit, mitzuhalten. Die Themen Digitale Fabrik, Industrie 4.0 und Building Information Modeling sind zunehmend im Einsatz in den jeweiligen Planungsdomänen einer Fabrik und leisten ihren eigenen Beitrag zur Beherrschung der Komplexität und Verbesserung der Planungsergebnisse. Offen ist, wie diese Elemente strukturiert zusammengeführt werden können, damit eine gesamtheitliche Lösung geplant, gestaltet und gesteuert werden kann. Der vorliegende Beitrag geht dieser Frage nach und postuliert eine Vision der „Fabrik der Zukunft“. In diesem zweiten Teil dieser Beitragsreihe werden die Gemeinsamkeiten der Elemente abgeleitet und zum Digitalen Zwilling verknüpft.
Are patients with polycystic ovary syndrome more prone to irritable bowel syndrome?
Authors: Kałużna Małgorzata , Kompf Pola , Wachowiak-Ochmańska Katarzyna , Moczko Jerzy , Królczyk Aleksandra , Janicki Adam , Szapel Karol , Grzymisławski Marian , Ruchała Marek , Ziemnicka Katarzyna 
Published: March 2022

Background
Polycystic ovary syndrome (PCOS) encompasses endocrine, reproductive and metabolic disturbances. Abdominal pain and bowel movement disturbances are common complaints of PCOS patients. It remains uncertain whether the characteristic features of PCOS are associated with an increased incidence of irritable bowel syndrome (IBS).

Methods
In the study, 133 patients with PCOS diagnosed according to international evidence-based guidelines and 72 age- and BMI-matched eumenorrheic controls were enrolled. Anthropometric measurements and biochemical and hormonal characteristics were collected. The Rome IV criteria were used for IBS diagnosis. Quality of life (QoL) and depressive symptoms were also assessed.

Results
IBS symptom prevalence in PCOS was not significantly different than in controls. Hyperandrogenism and simple and visceral obesity did not appear to affect IBS prevalence in PCOS. There were no anthropometric, hormonal or biochemical differences between IBS-PCOS and non-IBS-PCOS patients, apart from IBS-PCOS patients being slightly older and having lower thyroid-stimulating hormone. Metabolic syndrome (MS) prevalence was higher in IBS-PCOS than non-IBS-PCOS. QoL appears to be significantly lower in IBS-PCOS compared to PCOS-only patients. The occurrence of depression was higher in IBS-PCOS vs non-IBS-PCOS patients. At least one alarm symptom was reported by 87.5% of IBS-PCOS; overall, this group experienced more alarm symptoms than the IBS-only group.

Conclusions
Since a link between PCOS and IBS comorbidity and increased MS prevalence was noted, patients presenting with both conditions may benefit from early MS diagnostics and management. The high incidence of alarm symptoms in PCOS women in this study highlights the need for differential diagnosis of organic diseases that could mimic IBS symptoms.