bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time‐dependent natural convection fluid flow of stably stratified fluid in an asymmetrically heated vertical channel filled with an anisotropic porous material
Authors: Jha Basant K. , Musa Muhammad K. , Ajibade Abiodun O. 
Published: September 2022

AbstractThis paper presents a theoretical analysis of the combined effects of anisotropic porous material and thermal stratification on the transient natural convection fluid flow in an asymmetrically heated vertical parallel channel. The solutions of the governing equations for the temperature and velocity fields are obtained using Laplace transform technique, Riemann sum approximation, and the D'Alembert method. The choice of the D'Alembert method is to provide a simple decoupling procedure for the coupled governing equations while still retaining their original orders. The research established that owing to the layering effect induced by the thermal stratification , the temperature and the velocity distributions of the fluid are found to be attenuated with an increase in thermal stratification. It is also observed that the inclusion of anisotropic parameters in the transport equations aids in regulating the fluid velocity, temperature, Nusselt number, skin friction, and mass flow rate. In addition, by neglecting the anisotropic parameter and taking into account the adiabatic stratification of the fluid, the numerical values for the mass flow rate of the present research favorably compared with the numerical results obtained by Singh et al.
The incidence of neoplasm of uncertain behavior of uterus diagnosed after surgery for presumed leiomyoma: A national population‐based study
Authors: Yuk Jin‐Sung , Lee Jung Hun 
Published: September 2022

AbstractObjectiveTo investigate the incidence of neoplasm of uncertain behavior of uterus (NUBU) diagnosed after hysterectomy, myomectomy, or hysteroscopy for presumed leiomyomas.MethodsWe performed this population‐based retrospective cohort study using the Korean national health insurance database between January 2002 and December 2018. Women with or without NUBU diagnosed after surgery were extracted using diagnosis codes and procedure codes.ResultsThe median age of patients who underwent surgery for presumed leiomyomas was 39 years (interquartile range [IQR] 31–47 years). The median age of women diagnosed with NUBU after surgery was 45 years (IQR 38–49 years). The incidence of NUBU diagnosed after surgery for presumed leiomyomas was 1.89%. The incidences of NUBU diagnosed after hysterectomy, myomectomy, or hysteroscopic myomectomy for presumed leiomyomas were 2.03%, 1.84%, or 1.64%, respectively. There was no difference in the incidence of NUBU according to these surgical methods.ConclusionsRegardless of the surgical procedure performed, the incidence of NUBU diagnosed after surgery was higher than that of unexpected uterine malignancy diagnosed after hysterectomy (0.19%), myomectomy (0.12%), or hysteroscopic myomectomy (0.86%) for presumed leiomyoma. Compared with unexpected uterine malignancy, NUBU seems to occur in relatively young women.
Therapeutic plasma exchange as adjunct therapy for bullous pemphigoid
Authors: Phachu Deep , Elali Ibrahim , Garay Barbara , Attique Hassan , Kaplan Andre 
Published: September 2022

AbstractBullous pemphigoid (BP) is a rare autoimmune blistering disease caused by pathogenic antibodies which deposit into the dermo‐epidermal junction. We present a case of bullous pemphigoid in a young female refractory to initial therapy with immunosuppressives and steroids who experienced significant improvement in blister burden after a course of adjunct therapeutic plasma exchange (TPE). This case report provides valuable insight into the benefit of utilizing TPE for BP and provides treatment specifics regarding use of TPE in a patient with BP.
A simple unstructured kinetic model for anaerobic treatment of a class of agro‐industrial waste
Authors: Arroyo Claudio B. , Mendez‐Acosta Hugo O. , García‐Sandoval Juan P. , Leal‐Ascencio Teresa , Hernandez‐Martinez Eliseo 
Published: September 2022

AbstractBACKGROUNDDynamic modeling of the anaerobic treatment of agro‐industrial waste can help determine optimal operating conditions to maximize the process performance. For this, it is necessary to select an appropriate model and adapt it to the specific conditions of the substrate. In this work, a simple unstructured kinetic model for the anaerobic treatment of different agro‐industrial waste is proposed. The proposed model considers the three most relevant stages of anaerobic digestion (AD) and can be adapted for the treatment of different substrates, modes of operation (batch or continuous), and/or generated products (VFA or methane production), thus requiring a minimum of process macroscopic measurements.RESULTSTo evaluate the scope of the model, two case studies were analyzed: (i) methane production from tequila vinasse and agave hydrolysates, and (ii) volatile fatty acids (VFA) and biogas production from raw cheese whey. For each case, parameter estimations were performed using the Levenberg – Marquardt algorithm, which yielded a simplified model with high determination coefficients (R2 > 0.95). Moreover, the kinetic parameters estimated were consistent physically and statistically.CONCLUSIONNumerical results show that the proposed model can satisfactorily describe the dynamic behavior of the key variables of the three types of agro‐industrial waste evaluated. Therefore, the proposed model might be advantageous to determine the conditions that maximize performance without risking process stability. © 2022 Society of Chemical Industry (SCI).
Comparison of Elecsys and Liaison immunoassays to determine Epstein–Barr virus serological status using further diagnostic approaches to clarify discrepant results
Authors: Lupo Julien , Tsougaev Mansour , Blachier Stéphane , Chovelon Guillaume , Truffot Aurélie , Leroy Corentin , Giai Joris , Epaulard Olivier , Germi Raphaële , Morand Patrice 
Published: September 2022

AbstractSerological markers for Epstein–Barr virus (EBV) infection are commonly used to diagnose infectious mononucleosis and establish a serological status in pretransplant patients. This study prospectively assessed 1043 serum specimens sent to the laboratory for physician‐ordered EBV testing. The three markers—antiviral capsid antigen (VCA) immunoglobulin M (IgM), anti‐VCA immunoglobulin G (IgG), and anti‐Epstein–Barr nuclear antigen (EBNA) antibodies—were tested using the Elecsys and the Liaison immunoassays. Specimens with discrepant results between the two assays were assessed using further EBV diagnostic approaches to conclude on the EBV serological status. In spite of substantial agreement between the two assays (88%) and with the presumed EBV status (>92%), the results showed differences in the performance of the assays. Liaison VCA IgM appeared to be the most sensitive test for the detection of the 38 sera classified as early primary infection in comparison with the Elecsys assay (91.4% vs. 68.6%, p = 0.008). Excluding the cases of early primary infection, the sensitivity values of the VCA IgM marker were comparable between the Liaison and Elecsys assays (95.2% and 92.9%, respectively, p = 1). Concerning the sera classified as past infection (n = 763), the Elecsys assay showed higher sensitivity values for the detection of the VCA and EBNA IgG markers in comparison with the Liaison assay (99.9% and 99.7% vs. 97.4% and 91.2%, respectively, p < 0.001). Overall, the Elecsys and Liaison assays showed similar performance. The interpretation of EBV serological profiles based on the clinical context may require serology follow up or further diagnostic approaches in challenging cases.
Effectiveness of remdesivir with corticosteroids for COVID‐19 patients in intensive care unit: A hospital‐based observational study
Authors: Hanafusa Mariko , Nawa Nobutoshi , Goto Yuki , Kawahara Tomoki , Miyamae Shigeru , Ueki Yutaka , Nosaka Nobuyuki , Wakabayashi Kenji , Tohda Shuji , Tateishi Ukihide , Fujiwara Takeo 
Published: September 2022

AbstractThe effectiveness of remdesivir on survival in coronavirus disease 2019 (COVID‐19), especially in cases treated in the intensive care unit (ICU), is controversial. We investigated the effectiveness of remdesivir with corticosteroids on the survival of COVID‐19 patients in a real ICU clinical practice. For laboratory‐confirmed COVID‐19 patients admitted to the ICU of a tertiary hospital in Tokyo (April 2020–November 2021) and who received corticosteroids, the effectiveness of remdesivir for survival, stratified by interval length (within 9 or 10+ days), was retrospectively analyzed using Cox regression model. A total of 168 patients were included: 35 with no remdesivir use (control), 96 with remdesivir use within 9 days, and 37 with remdesivir use with an interval of 10+ days. In‐hospital mortality was 45.7%, 10.4%, and 16.2%, respectively. After adjusting for possible covariates including comorbidities, laboratory data, oxygen demand, or level of pneumonia, remdesivir use within 9 days from symptom onset reduced mortality risk (hazard ratio [HR]: 0.10; 95% confidence interval (CI): 0.025–0.428) compared to the control group. However, remdesivir use with an interval of 10+ days showed no significant association with mortality (HR: 0.42; 95% CI: 0.117–1.524). Among COVID‐19 patients who received corticosteroids in ICU, remdesivir use within 9 days from symptom onset was associated with reduced in‐hospital mortality risk.
Antibody response 6 months after the booster dose of Pfizer in previous recipients of CoronaVac
Authors: Silva Maria Francilene Souza , Pinto Ana Carolina Matias Dinelly , de Oliveira Fátima de Cássia Evangelista , Caetano Ludmilla Freire , Araújo Fernanda Montenegro de Carvalho , Fonseca Marcela Helena Gambim 
Published: September 2022

AbstractThe most widely used vaccines were messenger RNA (mRNA), viral vector, and inactivated virus with two‐dose schedules. In Brazil, the CoronaVac (Sinovac) was the first vaccine approved for emergency use, and the third dose was administered, preferably, with the BNT162b2 vaccine. We evaluated antibody levels after 6 months of the booster dose with BNT162B2 in previous recipients of CoronaVac and whether a subsequent severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) infection enhances the antibody response. We analyze the humoral response (spike [S] IgM for the SARS‐CoV‐2 and IgG for the S and nucleocapsid [N] proteins) in samples collected before the third dose and 6 months after the third dose. The presence of antibodies was measured by using Abbott Architect i2000SR. The IgM and IgG antispikes were stimulated mainly 30 days after the third dose (30d/3D), with a decline over time. The IgG anti‐N was stimulated predominantly in 90d/3D and 180d/3D. The N IgG levels were 50 and 35 times higher in the positive polymerase chain reaction (PCR) group in 90d/3D and 180d/3D, respectively. The S IgG titers were 1.5 times elevated in the positive PCR group, in 180d/3D. The BNT162b2 boosted the S IgG levels, decreasing after 60 days. The booster shot induced IgM and IgG antibodies against spike protein. Infection after vaccination increased antibodies against protein N.
Diagnostic Accuracy of Optic Nerve Sheath Diameter Measured With Ocular Ultrasonography in Acute Attack of Chronic Obstructive Pulmonary Disease
Authors: Copcuoglu Zeliha , Oruc Oya Akpinar 
Published: September 2022

ObjectiveThe study aimed to evaluate intracranial pressure changes by measuring ONSD before and after treatment in patients with chronic obstructive pulmonary disease (COPD).MethodsThe study was designed as a prospective analysis, in which 56 COPD in acute exacerbation and 50 volunteers. COPD severity was determined by the Dyspnea Scale of Modified Medical Research Council (mMRC). Measurements were made with ocular ultrasonography and linear probe in both eyes.ResultsBoth the right and left ONSDs were higher in the patient compared to the control (P = .017) and regressed after the treatment (P = .021). In the ROC analysis for the predictability of COPD, right eye ONSDs showed a predictive potential for COPD with %75.7 specificity and %68.1 sensitivity at 0.455 cut‐off (AUC: 0.727; P = .0001; %95CI: 0.609–0.833). Similar to the right eye, the left ONSD presented %74.4 specificity and %67 sensitivity at 0.505 cut‐off value (AUC: 0.718; P = .0001; %95CI: 0.608–0.841).ConclusionThe ONSD measurement that was with the help of ocular ultrasonography can be a useful diagnostic tool for symptomatic COPD presenting with an acute attack.
Oceanic lobate ctenophores possess feeding mechanics similar to the impactful coastal species Mnemiopsis leidyi
Authors: Cordeiro Malaika , Costello John H. , Gemmell Brad J. , Sutherland Kelly R. , Colin Sean P. 
Published: September 2022

AbstractLobate ctenophores are often numerically dominant members of oceanic epipelagic and midwater ecosystems. Despite this, little is known about their trophic ecology. Multiple, co‐occurring species are often found in these ecosystems and appear to feed similarly via feeding currents that entrain prey. We quantified the hydrodynamics, morphology, and behavior of four co‐occurring, cosmopolitan lobate species (Eurhamphaea vexilligera, Ocyropsis crystallina, Bolinopsis vitrea, and Leucothea multicornis) to evaluate whether their feeding mechanics lead to differential feeding rates and prey selection. We compared the feeding characteristics of these four oceanic species to the coastal lobate ctenophore, Mnemiopsis leidyi, which is known as a voracious zooplanktivore. We found that despite their morphological diversity, the five lobate species used the same mechanism to generate their feeding current—the hydrodynamics of their feeding currents were similarly laminar and with very low fluid deformation rates. Despite having similar feeding current traits, the species had different in situ swimming behaviors and feeding postures. We show that these different behaviors and postures lead to different prey encounter rates and that several of the oceanic species have the potential to feed at rates similar to or greater than M. leidyi. As such, the individual and combined trophic impact of oceanic lobate ctenophores is likely to be much greater than previously predicted.
Recent Advances in Graphitic Carbon Nitrides (g‐C3N4) as Photoluminescence Sensing Probe: A Review
Authors: Roy Richa , Chacko Anu Rose , Abraham Thomas , Korah Binila K , John Bony K , Punnoose Mamatha Susan , Mohan Chitra , Mathew Beena 
Published: September 2022

AbstractAmong the wide range of chemosensors, the development of fluorescent chemosensors has shown continued interest in the domains of chemistry, materials, biology, and ecology due to their simple operation, low cost, high sensitivity, specificity, live observation, and short response time. As a metal‐free and fluorescent chemosensor, graphitic carbon nitride (g‐C3N4) has emerged as a new research hotspot and received widespread interdisciplinary attention which is attributable to its favorable electrical band structure, high physicochemical stability, and “earth‐abundant” nature. This review summarizes the structure, synthetic methods, and various techniques for the modification of g‐C3N4. This review also covers the development of g‐C3N4 nanomaterials‐based sensors and their potential applications in a variety of fields. Furthermore, the comparative performance of various sensors, existing obstacles, and perspectives of g‐C3N4‐based nanomaterials are also outlined in detail.
Novel Mannich Bases of α‐Mangostin Bearing Methoxyphenyl Moieties with Antioxidant and Membrane‐protective activity
Authors: Buravlev Evgeny V. , Shevchenko Oksana G. 
Published: September 2022

AbstractA series of novel Mannich bases containing (monomethoxy‐, dimethoxy‐ or trimethoxy)phenyl substituent and morpholine fragment have been synthesizedviaC‐4‐monoaminomethylation of α‐mangostin, a natural hydroxyxanthone. This modification has led to a considerable reduction in erythrotoxicity of natural xanthone while preserving its high antioxidant activity. All synthesized derivatives have demonstrated higher radical scavenging activity and total antioxidant activity compared to those of α‐mangostin, several compounds have also shown higher efficacy in the test system with red blood cells. In the model of oxidative hemolysis of red blood cells induced by hydrogen peroxide and 2,2’‐azobis(2‐amidinopropane) dihydrochloride, a Mannich base containing 3,4,5‐trimethoxyphenyl substituent has been shown to have the highest membrane‐protective and antioxidant activity.
Activated Natural Killer Cells‐Dependent Dendritic Cells Recruitment and Maturation by Responsive Nanogels for Targeting Pancreatic Cancer Immunotherapy
Authors: Deng Junjie , Xu Weide , Lei Siyun , Li Wanyu , Li Qinghua , Li Kaiqiang , Lyu Jianxin , Wang Jilong , Wang Zhen 
Published: September 2022

AbstractAlthough enormous success has been obtained for dendritic cells (DCs)‐mediated antigen‐specific T cells anticancer immunotherapy in the clinic, it still faces major challenging problems: insufficient DCs in tumor tissue and low response rate for tumor cells lacking antigen expression, especially in low immunogenic tumors such as pancreatic cancer. Here, these challenges are tackled through tumor microenvironment responsive nanogels with prominent tumor‐targeting capability by Panc02 cell membranes coating and inhibition of tumor‐derived prostaglandin E2 (PGE2), aimed at improving natural killer (NK) cells activation and inducing activated NK cells‐dependent DCs recruitment. The engineered nanogels can on‐demand release acetaminophen to inhibit PGE2 secretion, thus promoting the activity of NK cells for non‐antigen‐specific tumor elimination. Furthermore, activated NK cells can secrete chemokines as CC motif chemokine ligand 5 and X‐C motif chemokine ligand 1 to recruit immature DCs, and then promote DCs maturation and induce antigen‐dependent CD8+ T cells proliferation for enhancing antigen‐specific immunotherapy. Notably, these responsive nanogels show excellent therapeutic effect on Panc02 pancreatic tumor growth and postsurgical recurrence, especially combination of the programmed cell death‐ligand 1 checkpoint‐blockade immunotherapy. Therefore, this study provides a simple strategy for enhancing low immunogenic tumors immunotherapy through an antigen‐independent way and antigen‐dependent way synergetically.
Automatisierte Schweißnahtnachbehandlung für Offshore‐Windenergieanlagen
Authors: Dänekas Christian , Heikebrügge Steffen , Kulikowski Jan , Heide Klaas Maximilian , Schaumann Peter , Breidenstein Bernd , Bergmann Benjamin 
Published: September 2022

AbstractFür die Umsetzung der klimapolitischen Ziele ist eine wirtschaftliche und ressourcenschonende Bauweise von Offshore‐Windenergieanlagen (OWEA) dringend erforderlich. Die Erhöhung der anzusetzenden Ermüdungsfestigkeit durch den Einsatz hochfester Stähle und durch die Anwendung von Schweißnahtnachbehandlungsmethoden bietet großes Potenzial zur Senkung des Materialeinsatzes und der Kosten bei Monopiles. Speziell in der automatisierten Fertigungskette der OWEA bieten sich automatisierte Prozesse wie das Festwalzen an. Festwalzen ist ein im Maschinenbau etabliertes mechanisches Bearbeitungsverfahren zur Erhöhung der Verschleiß‐ und Ermüdungsfestigkeit von metallischen Komponenten. Der vorliegende Aufsatz stellt Ergebnisse des Festwalzens als neuartige Nachbehandlungsmethode zur Erhöhung der Ermüdungsfestigkeit von Schweißnähten dar. Es werden die Oberflächen‐ und Randzoneneigenschaften UP‐geschweißter Stumpfnahtstöße aus einem Baustahl der Güte S355MLO vor und nach dem Festwalzen gezeigt. Um den Einfluss des Festwalzens auf die Nahtgeometrie zu quantifizieren, werden zusätzlich Ergebnisse von Messungen mit einem Laserliniensensor dargestellt. Abschließend werden die Ergebnisse der Ermüdungsversuche diskutiert, die das große Potenzial des Festwalzprozesses als Schweißnahtnachbehandlungsmethode aufzeigen.
A bridge to new physics: proposing new — and reviving old — explanations of aμ
Authors: Guedes Guilherme , Olgoso Pablo 
Published: September 2022

Abstract
The 4.2 σ tension in the combined measurement of the anomalous magnetic moment of the muon, aμ, and the Standard Model prediction strongly suggests the existence of beyond the Standard Model physics. Following the Standard Model Effective Field Theory approach, we study a particular topology, the bridge diagram, which gives a chirally enhanced contribution to aμ. We classify all possible 2- and 3-field SM extensions that can generate this contribution and present the full aμ result for them. Within our approach, we find that several 2-field fermion-scalar extensions which had been previously discarded in the literature — when only the Yukawa-suppressed contribution was considered — can actually be viable models to explain the observed anomaly. Furthermore, the 3-field extensions which generate the bridge diagram represent a new class of models to account for aμ. We explore a particular 3-field extension which, beyond explaining aμ, can also account for the neutral B-meson anomalies and the Cabibbo angle anomaly. We present the full one-loop matching for this model and a one-loop phenomenological study.
Research in orthopaedic trauma surgery: approaches of basic scientists and clinicians and the relevance of interprofessional research teams
Authors: Hildebrand Frank , Höfer Christine , Horst Klemens , Friemert Benedikt , Pennig Dietmar , Marzi Ingo , Stange Richard ,   Scientific Committee of the German Society for Trauma Surgery
Published: September 2022

Abstract
Background
An increasing clinical workload and growing financial, administrative and legal burdens as well as changing demands regarding work-life balance have resulted in an increased emphasis on clinical practice at the expense of research activities by orthopaedic trauma surgeons. This has led to an overall decrease in the number of scientifically active clinicians in orthopaedic trauma surgery, which represents a serious burden on research in this field. In order to guarantee that the clinical relevance of this discipline is also mirrored in the scientific field, new concepts are needed to keep clinicians involved in research.

Methods
Literature review and discussion of the results of a survey.

Results/conclusion
An interdisciplinary and -professional team approach involving clinicians and basic scientists with different fields of expertise appears to be a promising method. Although differences regarding motivation, research focuses, funding rates and sources as well as inhibitory factors for research activities between basic scientists and clinicians exist, successful and long-lasting collaborations have already proven fruitful. For further implementation of the team approach, diverse prerequisites are necessary. Among those measures, institutions (e.g. societies, universities etc.) must shift the focus of their support mechanisms from independent scientist models to research team performances.
Real-time optimization in electric vehicle stations using artificial neural networks
Authors: Elkasrawy M. A. , Abdellatif Sameh O. , Ebrahim Gamal A. , Ghali Hani A. 
Published: September 2022

AbstractThe current study proposes a smart decision-making algorithm to be utilized in electric vehicle stations. The suggested approach emphasizes the prediction of queuing delay seeking for minimum total charging time. For this purpose, artificial neural network (ANN) model is used, where a dataset is pre-generated to be seeded into the model. The proposed model effectiveness can be proven when the number of arriving vehicles at the station exceeds the maximum number of charging points at the station. The model accuracy was recorded to reach 89%. For validity, the proposed ANN model was evaluated with respect to a meta-heuristic optimizer, showing a reduced total charging time by 2.5%, and 23.9% with respect to a bare model with no optimization. As a final validation step, a physical realization of the ANN model was conducted by emulating a vehicle as a transmitting node and the station as a receiving node.