bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying possible inaccuracy in reported birth head circumference measurements among infants in the US Zika Pregnancy and Infant Registry
Authors: Roth Nicole M. , Woodworth Kate R. , Godfred‐Cato Shana , Delaney Augustina M. , Olson Samantha M. , Nahabedian John F. , Reynolds Megan R. , Jones Abbey M. , Neelam Varsha , Valencia‐Prado Miguel , Delgado‐López Camille , Lee Ellen H. , Ellis Esther M. , Lake‐Burger Heather , Tonzel Julius L. , Higgins Cathleen A. , Chan Ronna L. , Tong Van T. , Gilboa Suzanne M. , Cragan Janet D. , Honein Margaret A. , Moore Cynthia A. 
Published: March 2022

AbstractBackgroundThe US Zika Pregnancy and Infant Registry (USZPIR) monitors infants born to mothers with confirmed or possible Zika virus infection during pregnancy. The surveillance case definition for Zika‐associated birth defects includes microcephaly based on head circumference (HC).MethodsWe assessed birth and follow‐up data from infants with birth HC measurements <3rd percentile and birthweight ≥10th percentile to determine possible misclassification of microcephaly. We developed a schema informed by literature review and expert opinion to identify possible HC measurement inaccuracy using HC growth velocity and longitudinal HC measurements between 2 and 12 months of age. Two or more HC measurements were required for assessment. Inaccuracy in birth HC measurement was suspected if growth velocity was >3 cm/month in the first 3 months or HC was consistently >25th percentile during follow‐up.ResultsOf 6,799 liveborn infants in USZPIR, 351 (5.2%) had Zika‐associated birth defects, of which 111 had birth HC measurements <3rd percentile and birthweight ≥10th percentile. Of 84/111 infants with sufficient follow‐up, 38/84 (45%) were classified as having possible inaccuracy of birth HC measurement, 19/84 (23%) had HC ≥3rd percentile on follow‐up without meeting criteria for possible inaccuracy, and 27/84 (32%) had continued HC <3rd percentile. After excluding possible inaccuracies, the proportion of infants with Zika‐associated birth defects including microcephaly decreased from 5.2% to 4.6%.ConclusionsAbout one‐third of infants in USZPIR with Zika‐associated birth defects had only microcephaly, but indications of possible measurement inaccuracy were common. Implementation of this schema in longitudinal studies can reduce misclassification of microcephaly.
Children or adolescents who lost someone close during the Southeast Asia tsunami 2004 – The life as young
Authors: Adebäck Petra , Lundh Lena , Nilsson Doris 
Published: March 2022

AbstractIntroductionTo lose a person close suddenly, during childhood or adolescence, can be devastating. Many children or adolescents experienced the 2004 Indonesian tsunami when they were between 10‐ and 15‐years‐old. This study, from Stockholm, Sweden, describes the long‐term effects of loss, eight‐ or nine‐years post disaster, in young adulthood.MethodA mixed‐method approach was used including statistical analyses (n = 210) and interpretative phenomenological analysis (IPA).ResultsIt was shown that there was a significant difference between bereaved (n = 34) and nonbereaved (n = 176) respondents concerning, psychological distress, posttraumatic stress symptoms, and self‐rated health. Three themes were found by using the IPA approach (n = 9): Living in traumas, carrying heavy baggage, and living with change.ConclusionThe respondents described personal feelings of grief that are not expressed in their outward appearance or behavior in their daily living. When meeting young adults that have lost someone close in childhood or adolescence, this is important to have in mind.
Predicting Ki‐67 labeling index level in early‐stage lung adenocarcinomas manifesting as ground‐glass opacity nodules using intra‐nodular and peri‐nodular radiomic features
Authors: Zhu Minghui , Yang Zhen , Zhao Wei , Wang Miaoyu , Shi Wenjia , Cheng Zhenshun , Ye Cheng , Zhu Qiang , Liu Lu , Liang Zhixin , Chen Liangan 
Published: March 2022

AbstractObjectivesTo explore the diagnostic value of radiomics in differentiating between lung adenocarcinomas appearing as ground‐glass opacity nodules (GGO) with high‐ and low Ki‐67 expression levels.Materials and MethodsFrom January 2018 to January 2021, patients with pulmonary GGO who received lung resection were evaluated for potential enrollment. The included GGOs were then randomly divided into a training cohort and a validation cohort with a ratio of 7:3. Logistic regression (LR), decision tree (DT), support vector machines (SVM), and adaboost (AB) were applied for radiomic model construction. Area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of the established models.ResultsSeven hundred and sixty‐nine patients with 769 GGOs were included in this study. Two hundred and forty‐five GGOs were confirmed to be of high Ki‐67 labeling index (LI). In the training cohort, gender, age, spiculation sign, pleural indentation sign, bubble sign, and maximum 2D diameter of the nodule were found to be significantly different between high‐ and low Ki‐67 LI groups (p < 0.05), and spiculation sign and maximum 2D diameter of the nodule were further confirmed to be risk factors for Ki‐67 LI. The radiomic model established using SVM exhibited an AUC of 0.731 in the validation cohort, which was higher than that of the clinical‐radiographic model (AUC = 0.675). Moreover, radiomic model combining both intra‐ and peri‐nodular features showed better diagnostic efficacy than using intra‐nodular features alone (AUC = 0.731 and 0.720, respectively).ConclusionsThe established radiomic model exhibited good diagnostic efficacy in differentiating between lung adenocarcinoma GGOs with high and low Ki‐67 LI, which was higher than the clinical‐radiographic model. Peri‐nodular radiomic features showed added benefits to the radiomic model. As a novel noninvasive method, radiomics have the potential to be applied in the preliminary classification of Ki‐67 expression level in lung adenocarcinoma GGOs.
Baoshanmycin and a New Furanone Derivative from a Soil‐Derived Actinomycete, Amycolatopsis sp. YNNP 00208
Authors: Qian Meng‐An , Yang Ya‐Bin , Hu Bin‐Yuan , Xu Yuan , Wang Zi‐Hang , Li Qin‐Yuan , Gao Yu‐Hong , Luo Xiao‐Dong , Zhao Li‐Xing 
Published: March 2022

AbstractActinomycetes have being regarded as a treasure reservoir of various bioactive secondary metabolites and devoted many antibiotics in clinicals. Amycolatopsis sp. YNNP 00208 was isolated from a soil sample collected in Gaoligong Mountain area, Yunnan Province, China. Chemical investigation of its fermentation broth led to a new amide, baoshanmycin (1), and a new furanone derivative, 3‐(1,3‐dihydroxybutyl)‐4‐methylfuran‐2(H)‐one (2), together with eight known compounds, including two amides (3–4), four cyclic dipeptides (5–8), and two deoxyribonucleosides (9–10). Their structures were established on basis of the 1D‐ and 2D‐NMR spectroscopic data, along with the HR‐ESI‐MS experiments. Baoshanmycin (1) showed moderate antimicrobial activities against Candida albicans, and weak activities against Staphylococcus aureus, multi‐drug resistant Staphylococcus aureus, Bacillus subtilis, Listeria monocytogenes, fluconazole‐resistant Candida albicans. Baoshanmycin (1) presented strong antioxidant activity and moderate anti‐acetylcholinesterase activity. The other compound 3‐(1,3‐dihydroxybutyl)‐4‐methylfuran‐2(H)‐one (2) and the known compounds (3–10) showed moderate antioxidant activity.
ERK1b, a 46‐kDa ERK isoform that is differentially regulated by MEK
Authors: Yung Yuval , Yao Zhong , Hanoch Tamar , Seger Rony 
Published: March 2022

AbstractThe extracellular signal‐regulated kinases (ERK) 1 and 2 (ERK1/2) are members of the mitogen‐activated protein kinase family. Using various stimulated rodent cells and kinase activation techniques, we identified a 46‐kDa ERK. The kinetics of activation of this ERK isoform was similar to that of ERK1 and ERK2 under most but not all circumstances. We purified this isoform from rat cells followed by its cloning. The sequence of this isoform revealed that it is an alternatively spliced version of the 44‐kDa ERK1 and therefore we termed it ERK1b. Interestingly, this isoform had a 26‐amino acid insertion between residues 340 and 341 of ERK1, which results from Intron 7 insertion to the sequence. Examining the expression pattern, we found that ERK1b is detected mainly in rat and particularly in Ras‐transformed Rat1 cells. In this cell line, ERK1b was more sensitive to extracellular stimulation than ERK1 and ERK2. Moreover, unlike ERK1 and ERK2, ERK1b had a very low binding affinity to MEK1. This low interaction led to nuclear localization of this isoform when expressed together with MEK1 under conditions in which ERK1 and ERK2 are retained in the cytoplasm. In addition, ERK1b was not coimmunoprecipitated with MEK1. We identified a new, 46‐kDa ERK alternatively spliced isoform. Our results indicate that this isoform is the major one to respond to exogenous stimulation in Ras‐transformed cells, probably due to its differential regulation by MAPK/ERK kinase and by phosphatases.
Examining the interplay of attention‐deficit/hyperactivity disorder symptoms and trait anger as contributing factors to institutional misconduct among justice‐involved adolescents
Authors: Ramsey Kathleen L. , Smith Stephanie D. , Batastini Ashley B. , Walbridge Fayth D. 
Published: March 2022

AbstractBackgroundAlthough justice‐involved adolescents have a higher prevalence of trait anger and of attention‐deficit/hyperactivity disorder (ADHD) than adolescents in the general population, these factors have not been examined in relation to institutional misconduct.AimsWe sought to examine associations between ADHD symptoms and misconduct, including aggression, disruptive behaviours and other rule‐violating behaviours among adolescents in a maximum‐security residential facility run by the Department of Juvenile Justice and to test the moderating effect of trait anger on such relationships.MethodsArchival data collected from April 2010 to May 2011 comprising a resident cohort (N = 119) of justice‐involved adolescents (mean age = 16.74) were analysed; 30% were White and 70% Black. Self‐report measures of ADHD symptoms and trait anger were collected 2 weeks after their admission to the facility. Behavioural write‐ups of rule violations issued by facility staff during the month following the collection of these measures were coded according to the different forms of institutional misconduct.ResultsAnalyses revealed that trait anger significantly predicted disruptive behaviours occurring within a 1‐month time frame following the administration of the anger measure; it also predicted all other rule violating behaviours except aggression. ADHD symptoms, by contrast, were only marginally predictive. Trait anger did not moderate this small relationship between ADHD symptoms and institutional misconduct.ConclusionsThese findings that adolescents with a chronic tendency to feel angry are more likely to violate a variety of institutional rules during the first few weeks of admission to a juvenile justice maximum‐security residential facility suggest that early intervention efforts are needed to minimise harm within the institution and to prevent these adolescents from continuing on this trajectory, which may affect the conditions of their release.
Validation of a novel staging classification system based on the extent of cardiac damage among Chinese patients after transcatheter aortic valve replacement: A single‐center retrospective study
Authors: Zhu Qifeng , Yuan Zhengdu , Xu Yeming , Chen Jun , Ng Stella , Yidilisi Abuduwufuer , Ren Kaida , Chen Yuwen , Hu Wangxing , Zhu Gangjie , Liu Feng , Dang Mengqiu , He Yuxin , Guo Yuchao , Fan Jiaqi , Liu Xianbao , Wang Jian'an 
Published: March 2022

AbstractObjectivesWe aimed to validate a novel staging system for aortic stenosis (AS) in a Chinese patient cohort undergoing transcatheter aortic valve replacement (TAVR), and to compare this classification system to the traditional Society of Thoracic Surgeons (STS) score for TAVR risk stratification.BackgroundA novel staging system for AS based on the extent of cardiac damage upon echocardiography was recently proposed.MethodsPatients were prospectively enrolled into the Transcatheter Aortic Valve Replacement Single Center Registry in Chinese Population and analyzed retrospectively following additional exclusion criteria. On the basis of echocardiographic findings of cardiac damage, patients were classified into five stages (0–4).ResultsA total of 427 patients were included in the current analysis. Forty‐eight deaths occurred during a median follow‐up of 730 days following TAVR. The staging system showed a statistically significant association between cardiac damage and all‐cause mortality; advanced stages were associated with higher mortality. In a multivariate‐adjusted Cox proportional hazards regression model, stage and STS scores served as risk factors for 2‐year mortality. Each increment in the staging class was associated with an increased risk of mortality (hazard ratio, 1.275; 95% confidence interval [CI], 1.052–1.545). Receiver operating characteristic (ROC) curves were plotted for stage (area under the curve, 0.644; 95% CI, 0.562–0.725) and STS score (0.661; 0.573–0.749), and with no statistically significant differences between ROC curves (p = 0.920).ConclusionsWe validated a novel staging system as a key risk factor for 2‐year mortality in a Chinese TAVR patient cohort. Efficacy for risk stratification was comparable to the STS score.
Population Balance Modeling and Multi‐Response Optimization of a Swirling‐Flow Nanobubble Generator
Authors: Syaeful Alam Hilman , Sutikno Priyono , Soelaiman Tubagus Ahmad Fauzi , Sugiarto Anto Tri 
Published: March 2022

AbstractA novel model is proposed to optimize a swirling‐flow nanobubble generator utilizing a combined model of computational fluid dynamics‐population balance method (CFD‐PBM) coupled model and response surface method (RSM). The CFD‐PBM coupled model was validated by experiments based on the bubble size distribution and mass transfer. The validated model was utilized as an input for optimization using RSM. Optimization involved three factors and four target responses obtained by applying a central composite design (CCD). The adequacy of the models was evaluated by analysis of variance. Based on the optimization results, the proposed model can produce an optimized and feasible solution as a reference in the design of a nanobubble generator and can be applied further on a larger scale.
Production of Heterocyclic Primary Amines from Heterocyclic Aldehydes on Ni‐Mo/ZrO2
Authors: Bai-cheng Feng , Bao-hu Xi , Zhen-chao Zhang , Yu-hui Hou , Yan Jin , Qing-lin Yao 
Published: March 2022

AbstractNi‐Mo/ZrO2 catalysts with Ni‐Mo loadings of 10 wt % were prepared by a sol‐gel method on a ZrO2 support and subsequently applied in the simple reductive amination of heterocyclic aldehydes. Among the various catalysts prepared, Ni‐Mo/ZrO2 catalysts with Ni:Mo = 2:1 exhibited the highest metal dispersion and the smallest Ni particle size. The results showed that the catalyst has good catalytic performance, in which the yield of furfurylamine can reach 96.6 %. Initially, oximes were synthesized from the corresponding aldehydes and hydroxylamine hydrochloride, and then heterocyclic primary amines were synthesized by simple hydroreductive amination of the oximes with a 12 % methanolic solution of NH3 in the presence of an Ni‐Mo/ZrO2 catalyst. The methanolic solution of NH3 was found to be more effective in inhibiting the formation of secondary and tertiary amines.
Dynamic Control of Microbial Movement by Photoswitchable ATP Antagonists
Authors: Thayyil Sampreeth , Nishigami Yukinori , Islam Md. Jahirul , Hashim P. K. , Furuta Ken'ya , Oiwa Kazuhiro , Yu Jian , Yao Min , Nakagaki Toshiyuki , Tamaoki Nobuyuki 
Published: March 2022

AbstractAdenosine triphosphate (ATP) is the energy source for various biochemical processes and biomolecular motors in living things. Development of ATP antagonists and their stimuli‐controlled actions offer a novel approach to regulate biological processes. Herein, we developed azobenzene‐based photoswitchable ATP antagonists for controlling the activity of motor proteins; cytoplasmic and axonemal dyneins. The new ATP antagonists showed reversible photoswitching of cytoplasmic dynein activity in an in vitro dynein‐microtubule system due to the trans and cis photoisomerization of their azobenzene segment. Importantly, our ATP antagonists reversibly regulated the axonemal dynein motor activity for the force generation in a demembranated model of Chlamydomonas reinhardtii. We found that the trans and cis isomers of ATP antagonists significantly differ in their affinity to the ATP binding site.
Atomic Layer Deposited Ti2O3 Thin Films
Authors: Manjunath K. , Saraswat A. , Samrat D. , Rao C. N. R. 
Published: March 2022

AbstractTi2O3 thin films have been prepared through atomic layer deposition and subjected to electrical resistivity measurements as a function of temperature. The as‐prepared films were stable for up to three weeks. In Ti2O3 thin films, the insulator‐metal transition is observed at ∼80 K, with nearly 3–4 orders of magnitude change in resistivity. The anomalous increase in electrical resistivity in the films is in accordance with the two‐band model. However, the energy interval between the bands depending on the crystallographic c/a ratio leads to a change in electrical resistivity as a function of temperature.
Structures and Electromagnetic Properties of Boron Nitride Nanoribbons Doped with Transition Metals
Authors: Ma Jiajun , Wang Yang 
Published: March 2022

AbstractInspired by the recent discovery of the Ti‐doped BN nanocages, here we report the design of novel boron nitride (BN) nanoribbons (BNNRs) doped with fourth‐row transition metals (Sc−Cu) and the prediction of their structural and electromagnetic properties. First‐principles calculations and ab initio molecular dynamics simulations show that Ti‐doped BNNR possesses both thermodynamic and kinetic stability at high temperatures for synthesis of BN materials. Metal doping may make the nonmagnetic pristine BNNR ferromagnetic or antiferromagnetic, depending on the metal. The doping with all considered metals reduces substantially the band gap of pristine BNNR. For example, Sc‐doped BNNR is ferromagnetic with an indirect band gap of 1.18 eV, while V‐doped nanoribbon is antiferromagnetic with a direct gap of 2.50 eV. Remarkably, the carrier mobility in both materials is significantly enhanced compared to the pristine BNNR. Our findings suggest that doping with different metals may endow BNNRs with versatile electronic and magnetic properties.
Three‐dimensional quantification of the relationship between the upper first molar and maxillary sinus
Authors: Regnstrand Tobias , Ezeldeen Mostafa , Shujaat Sohaib , Ayidh Alqahtani Khalid , Benchimol Daniel , Jacobs Reinhilde 
Published: March 2022

AbstractObjectivesThe present study aims to describe the relationship between upper first molar roots and maxillary sinus, for the first time with a truly three‐dimensional approach.MethodsFrom a retrospective cone‐beam computed tomography (CBCT) sample of the upper jaw, a total of 105 upper first molars in contact with maxillary sinus from 74 patients (male 24, female 50, mean age 42) were included in the present study. Segmentation of the upper first molar and maxillary sinus in CBCT was performed utilizing a semiautomatic livewire segmentation tool in MeVisLab v.3.1. The segmentations were analyzed in 3‐matic Medical 20.0 for root volume and the contact area between upper first molar roots and maxillary sinus. Analysis of variance test was applied to detect statistically significant differences between the roots.ResultsThe palatal root had the largest contact area with maxillary sinus 27.8 ± 21.4 mm2 (20% of the root area) followed by the mesiobuccal 20.5 ± 17.9 mm2 (17% of the root area) and distobuccal root 13.7 ± 12 mm2 (14% of the root area). A significant difference in the contact area of the different roots of the upper first molar was seen.ConclusionsThis study showed that 70% of the upper first molars were in contact with the maxillary sinus. The palatal root had on average a fifth of its root surface in contact with the sinus, while for mesiobuccal this was a sixth of its root surface and distobuccal roots this was somewhat less. The true 3D relationship could help to better understand maxillary anatomy in relation to occurring pathologies and treatment planning in this area.
Diagnostic performance of nuclear matrix protein 22 and urine cytology for bladder cancer: A meta‐analysis
Authors: Wang Jie , Zhao Xi , Jiang Xiao Lei , Lu Dong , Yuan Qiang , Li Jiabing 
Published: March 2022

AbstractPurposeTo compare and analyze the diagnostic efficacy of nuclear matrix protein 22 (NMP22) and urine cytology (UC) in the diagnosis of bladder cancer.MethodsSearch the Chinese and English studies on NMP22 and urinary cytology in the diagnosis of bladder tumors published between 1999 and June, and conduct quality evaluation, data extraction and analysis.ResultsA total of 397 related articles were retrieved, and 12 articles were finally included after screening, including 2456 subjects. The heterogeneity test shows that there is no discernible threshold effect. Perform meta‐analysis according to the random effects model. The results showed that the total sensitivity of NMP22 and UC were 0.79 (95% CI [0.73, 0.84]) (CI: Confidence interval), 0.55 (95% CI [0.41, 0.69]), and the total specificity 0.59 (95% CI [0.46], respectively, 0.71), 0.91 (95% CI (0.81, 0.96]), +LR 1.9 (95% CI [1.4, 2.6]) (+LR: positive likelihood ration), 5.9 (95% CI [3.3, 10.6]), −LR 0.35 (−LR: negative likelihood ration), respectively (95% CI [0.27, 0.47]), 0.49 (95% CI [0.38, 0.64]), diagnostic odds ratios 5 (95% CI [3, 9]), 12 (95% CI [7, 21]). The area under the summary receiver operating characteristics curve (AUC) was 0.79 (95% CI [0.75, 0.82]) and 0.81 (95% CI [0.77, 0.84]), respectively.ConclusionsNMP22 has moderate diagnostic efficiency for bladder cancer. Its sensitivity is greater than UC, but its specificity is significantly lower than that of UC. At present, it cannot replace traditional cystoscopy and UC, but it can be combined to detect bladder tumors. It plays a major role in screening, postoperative monitoring and follow‐up.