bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral optic disc edema as a possible complication of cabozantinib use–a case report
Authors: Huang Yu-Te , Lin Chun-Ju , Tsai Yi-Yu , Hsia Ning-Yi 
Published: February 2022

Introduction Cabozantinib, which was approved by the Food and Drug Administration (FDA) in 2012, is a tyrosine kinase inhibitor widely used in the treatment of metastatic renal cell carcinoma (RCC) and medullary thyroid carcinoma. To date, no ocular adverse events have been reported by the FDA or on the package label. Here, we described a patient with metastatic RCC who developed bilateral optic disc edema after a 4-month course of cabozantinib. Case description A 55-year-old ethnic Chinese male with RCC with multiple metastases presented to our department with progressive blurred vision in both eyes for 1 month. He started taking cabozantinib 60 mg once daily 5 months prior to this presentation. Poor visual acuity and bilateral disc edema were then noted. Cabozantinib was discontinued after that, and 3-day pulse steroid therapy with methylprednisolone 1 g/day was given. The optic disc edema subsided gradually with limited improvement in visual acuity. Conclusion Bilateral optic edema should be considered as a complication associated with cabozantinib. We propose discontinuation of the treatment in cases such as that, and pulse steroid therapy should be considered if there is no contraindication.
Beyond forced telehealth adoption: A framework to sustain telehealth among allied health services
Authors: Thomas Emma E , Taylor Monica L , Ward Elizabeth C , Hwang Rita , Cook Renee , Ross Julie-Anne , Webb Clare , Harris Michael , Hartley Carina , Carswell Phillip , Burns Clare L , Caffery Liam J 
Published: February 2022

Introduction As COVID-19 restrictions reduce globally, services will determine what components of care will continue via telehealth. We aimed to determine the clinician, service, and system level factors that influence sustained use of telehealth and develop a framework to enhance sustained use where appropriate. Methods This study was conducted across 16 allied health departments over four health service facilities (Brisbane, Australia). It used a multi-method observational study design, involving telehealth service activity data from hospital administrative databases and qualitative interviews with allied health staff (n  =  80). Data were integrated and analysed using Greenhalgh's Non-adoption, Abandonment, Scale-up, Spread, and Sustainability framework. Results Increased telehealth use during the peak COVID period reverted to in-person activity as restrictions eased. Telehealth is unlikely to be sustained without a clear strategy including determination of roles and responsibilities across the organisation. Clinician resistance due to forced adoption remains a key issue. The main motivator for clinicians to use telehealth was improved consumer-centred care. Benefits beyond this are needed to sustain telehealth and improvements are required to make the telehealth experience seamless for providers and recipients. Data were synthesised into a comprehensive framework that can be used as a blueprint for system-wide improvements and service enhancement or redesign. Discussion Sustainability of telehealth activity beyond the peak COVID period is unlikely without implementation strategies to address consumer, clinician, service, and system factors. The framework can inform how these strategies can be enacted. Whilst developed for allied health disciplines, it is likely applicable to other disciplines.
Practical and emotional preparation for death: A mixed methods study investigating experiences of family carers of people with dementia
Authors: Fisher Emily , Crawley Sophie , Sampson Elizabeth L , Cooper Claudia , Jones Rebecca , Anantapong Kanthee , Moore Kirsten 
Published: February 2022

Background When family carers are more prepared for the end of the life of a person they care for, they report improved bereavement outcomes. Few studies have explored how carers prepare for the death of a person with dementia. We aimed to explore how carers for people with all stages of dementia experience preparing for end of life care and death. Methods This was a mixed methods cross-sectional study. Family carers of people with dementia ( n = 150) completed a structured interview with validated scales, alongside questions about death preparedness and advance decisions. A sub-sample ( n = 16) completed qualitative interviews exploring their experiences of planning for end of life. We fitted logistic regression models to explore associations with preparedness, and thematically analysed qualitative data. Results We addressed practical and emotional preparation separately for 143 participants. Fifty seven percent of participants were very practically prepared for death, while only 29% were very emotionally prepared. Male carers were more likely than female carers to report being very emotionally and practically prepared. Higher engagement with healthcare professionals was associated with feeling very practically prepared; although we found that formal discussions of end of life care issues with healthcare professionals did not impact carers’ feelings of preparation. Higher levels of dementia severity and carer depression were associated with feeling very emotionally prepared. Three qualitative themes related to practical and emotional preparation were identified: (1) ambiguity and uncertainty; (2) support from the system; and (3) how death is perceived by the carer. Conclusions While most carers felt practically prepared for death, emotional preparation was much lower. Further research is needed to understand how engagement with healthcare professionals or other forms of social or emotional support could help carers, particularly female carers, to emotionally prepare for their relative’s death.
Investigating the electromagnetic wave-absorbing, water repellency, and flame-retardant effectiveness of nickel–iron/PPTA-blended knitted fabrics
Authors: Li Rui , Wei Sainan , Xu Jia , Yan Ruosi , Xu Jianlin 
Published: February 2022

In recent decades, electromagnetic wave pollution has become more and more serious. In order to reduce the adverse effects of these waves, the nickel–iron/polymers of p-phenylene terephthamide (PPTA)–blended single yarn and plied yarn were manufactured, and the nickel–iron fibers with various contents (10%, 15%, and 20%) as raw materials were used. Nickel–iron/PPTA-blended yarns were knitted with three knit structures and three looped deep (11.25, 11.50, and 12.00 mm). The electromagnetic absorption effect was examined using the reflectance arch method at a frequency range between 2 and 18 GHz. The results show that the fabric with plied yarn, nickel–iron fiber content of 10%, looped deep of 12.00 mm, and loop notation of structure C has the best electromagnetic wave absorption performance, which can reach −30 dB reflectivity at 5.1 GHz, and the bandwidth with reflectivity lower than −5 dB reaches 2.5 GHz. In order to make the fabric obtain more functions, water-repellent treatment of the fabric is carried out. The results show that the best finishing effect can be obtained by using 40% water repellent and drying at 170°C for 5 min so that the sample can resist the hydrostatic pressure of 49.1 kPa. Finally, through the vertical burning test, the flame retardancy of the fabric can reach level B1.
Research Topics and Collaboration in Human Resource Development Review 2012–2021: A Bibliometrics Approach
Authors: Yoon Seung Won , Chae Chungil 
Published: February 2022

In celebrating HRDR’s 20 years of publication, this study aims to shed light on research trends in the journal and future research needs by examining 10 years of publications from a structural perspective. We used three complementary computational methods to find major research trends and themes including keyword network analysis, topic modeling, and bibliographic coupling. This paper presents the findings on the research themes, structural coherence, and semantic relevance based on clusters formed by normalized distance measures. Connectivity, co-appearances, and citations are important forms of scholarly communication that represent the body of knowledge in the field. Our findings indicate that research topics greatly expanded beyond the early HRD research topics of learning and development to include various topics related to diversity, critical HRD, and equity issues in organizations and society. We also examined the author-institution-keywords affiliation network and the authors-collaboration network to suggest how scholars can collaborate more in the future.
Outcomes of Visceral Arterial Reconstruction: A Systematic Review
Authors: D’Souza Rovan Evan , Girish Girish , D’Souza Preethy , Lewis Melissa Glenda , Renjith Vishnu 
Published: February 2022

Aims: The study aimed to review the use of synthetic grafts (SGs) and autologous vein grafts (AVGs) in visceral arterial reconstruction (VAR) in chronic visceral ischaemia. Methods: Systematic review methodology was employed. Results: Six studies were included (218 patients and 281 vessels). Two studies had data about AVG only, 3 had data about SG only and 1 had both AVG and SG data. Three studies reported outcomes for AVG (117 patients and 132 vessels revascularized). One-year primary patency was 87% (95% CI 71%, 97%). Graft thrombosis rate was 6% (95% CI 0%, 16%). Pooled stenosis rate at one-year was 11% (95% CI 1%, 28%). The 30-day (n = 96), one-year (n = 72) and 5-year mortality (n = 30) were 0%, 0% and 12%, respectively. Four studies reported outcomes for SGs (106 patients and 147 vessels). The pooled primary patency at one year was 100% (95% CI 99%, 100%). Pooled primary 5-year patency rate was 88% (95% CI 69%, 100%). There was no graft infection in 2 of the 3 studies. Overall pooled percentage of graft thrombosis and stenosis at one year was 0%. Jimenez et al. (2002) reported one graft thrombosis at 20 months and graft stenosis in 2 patients at 46 and 49 months. Illuminati et al (2017) reported graft thrombosis in 2/24 patients at 22 and 52 months. Thirty days, one-year and 5-year mortality was 1% (95% CI 0%, 6), 7% (95% CI 0%, 20%) and 39% (95% CI 11%), respectively. Conclusion: Patency was better with SG compared with AVG. Mortality was higher in the SG group. Graft dilatation does occur with vein grafts, but in this review no intervention was found necessary. Poorly designed studies, incomplete reporting and absence of morbidity and mortality indices preclude emphatic conclusions.
A systematic review of exercise intervention reporting quality and dose in studies of intermittent claudication
Authors: Ibeggazene Saïd , Pymer Sean , Birkett Stefan T , Caldow Edward , Harwood Amy E 
Published: February 2022

Background Exercise therapy is an important treatment option for people with intermittent claudication (IC). Appropriate reporting of exercise interventions in populations with IC within randomised controlled trials (RCTs) is important to ensure that research can be translated into clinical practice. Therefore, the purpose of our review is to evaluate the reporting of exercise interventions in RCTs of exercise therapy in patients with IC. Methods A systematic search was performed to identify relevant trials in patients with IC published until May 2020. Studies including only participants with critical limb ischaemia or asymptomatic peripheral artery disease were excluded. Each trial was scored using the recently developed ‘Consensus on Exercise Reporting Template’ (CERT) which has a maximum obtainable score of 19. Results Of 1489 unique records identified from the search, 73 trials were included, reporting 107 exercise interventions. Overall, the average CERT score was 10/19. The exercise equipment used, the use of supervision and a description of whether the exercise prescription was tailored or generic were the most frequently reported intervention components. The motivational strategies used, intervention adherence and intervention fidelity were the most underreported CERT components. There was no trend indicating that CERT scores were higher in more recent publications. Conclusions We have identified that important details about exercise interventions are frequently missing from the published literature. These missing data hinder replication of research findings and limit the translation of evidence into clinical practice.
Bayesian basket trial design with false-discovery rate control
Authors: Zabor Emily C , Kane Michael J , Roychoudhury Satrajit , Nie Lei , Hobbs Brian P 
Published: February 2022

Background: Recent advances in developing “tumor agnostic” oncology therapies have identified molecular targets that define patient subpopulations in a manner that supersedes conventional criteria for cancer classification. These successes have produced effective targeted therapies that are administered to patients regardless of their tumor histology. Trials have evolved as well with master protocol designs. By blending translational and clinical science, basket trials in particular are well-suited to investigate and develop targeted therapies among multiple cancer histologies. However, basket trials intrinsically involve more complex design decisions, including issues of multiple testing across baskets, and guidance for investigators is needed. Methods: The sensitivity of the multisource exchangeability model to prior specification under differing degrees of response heterogeneity is explored through simulation. Then, a multisource exchangeability model design that incorporates control of the false-discovery rate is presented and a simulation study compares the operating characteristics to a design where the family-wise error rate is controlled and to the frequentist approach of treating the baskets as independent. Simulations are based on the original design of a real-world clinical trial, the SUMMIT trial, which investigated Neratinib treatment for a variety of solid tumors. The methods studied here are specific to single-arm phase II trials with binary outcomes. Results: Values of prior probability of exchangeability in the multisource exchangeability model between 0.1 and 0.3 provide the best trade-offs between gain in precision and bias, especially when per-basket sample size is below 30. Application of these calibration results to a re-analysis of the SUMMIT trial showed that the breast basket exceeded the null response rate with posterior probability of 0.999 while having low posterior probability of exchangeability with all other baskets. Simulations based on the design of the SUMMIT trial revealed that there is meaningful improvement in power even in baskets with small sample size when the false-discovery rate is controlled as opposed to the family-wise error rate. For example, when only the breast basket was active, with a sample size of 25, the power was 0.76 when the false-discovery rate was controlled at 0.05 but only 0.56 when the family-wise error rate was controlled at 0.05, indicating that impractical sample sizes for the phase II setting would be needed to achieve acceptable power while controlling the family-wise error rate in this setting of a trial with 10 baskets. Conclusion: Selection of the prior exchangeability probability based on calibration and incorporation of false-discovery rate control result in multisource exchangeability model designs with high power to detect promising treatments in the context of phase II basket trials.
‘Ticked off’? Can a new outcomes-based postgraduate curriculum utilising programmatic assessment reduce assessment burden in Intensive Care Medicine?
Authors: Smith Christopher , Patel Mumtaz 
Published: February 2022

Context Increasing dissatisfaction with existing methods of assessment in the workplace alongside a national drive towards outcomes-based postgraduate curricula led to a recent overhaul of the way Intensive Care Medicine (ICM) trainees are assessed in the United Kingdom. Programmatic assessment methodology was utilised; the existing ‘tick-box’ approach using workplace-based assessment to demonstrate competencies was de-emphasised and the expertise of trainers used to assess capability relating to fewer, high-level outcomes related to distinct areas of specialist practice. Methods A thematic analysis was undertaken investigating attitudes from 125 key stakeholders, including trainees and trainers, towards the new assessment strategy in relation to impact on assessment burden and acceptability. Results This qualitative study suggests increased satisfaction with the transition to an outcomes-based model with capability judged by educational supervisors. However, reflecting frustration relating to current assessment in the workplace, participants felt assessment burden has been significantly reduced. The approach taken was felt to be an improved method for assessing professional practice; there was enthusiasm for this change. However, this research highlights trainee and trainer anxiety regarding how to ‘pass’ these expert judgement decisions of capability in the real world. Additionally, concerns relating to the impact on subgroups of trainees due to the potential influence of implicit biases on the resultant fewer but ‘higher stakes’ interrogative judgements became apparent. Conclusion The move further towards a constructivist paradigm in workplace assessment in ICM reduces assessment burden yet can provoke anxiety amongst trainees and trainers requiring considered implementation. Furthermore, the perception of potential for bias in global judgements of performance requires further exploration.
Magnitude and determinants of knowledge towards pregnancy danger signs among pregnant women attending antenatal care at Chiro town health institutions, Ethiopia
Authors: Getachew Dagnachew , Getachew Tamirat , Debella Adera , Eyeberu Addis , Atnafe Genanew , Assefa Nega 
Published: February 2022

Objectives: This study aimed to assess the magnitude and determinants of knowledge of pregnancy danger signs in Chiro town health institutions, Ethiopia. Methods: Institutional-based cross-sectional study was conducted among 395 systematically selected pregnant mothers. An interviewer-administered pretested questionnaire was used to collect data. The data were entered into EPI data version 3.1 and analyzed using SPSS version 22. Bi- and multivariate logistic regression analyses were used to identify determinant factors. Statistical significance was declared at p < 0.05. Results: Even though 58.0% of respondents recalled at least one danger sign of pregnancy, only 26.3% (95% confidence interval: 21.7–30.7) of the respondents had good knowledge of pregnancy danger signs. Residence (adjusted odds ratio = 2.43, 95% confidence interval: 1.50–4.00), distance to health facility (adjusted odds ratio = 2.11, 95% confidence interval: 1.28–3.47), and income (adjusted odds ratio = 1.99, 95% confidence interval: 1.22–3.33) were found to be significantly associated with mothers’ knowledge of pregnancy danger signs. Conclusion: The overall women’s knowledge of the danger signs of pregnancy was poor. Monthly income, distance to health facilities, and residence were determinant factors of mothers’ knowledge of pregnancy danger signs. Thus, the provision of information targeting pregnant women, their families, and the general community regarding danger signs of pregnancy is recommended to health care providers.
Knowledge, attitude, and associated factors toward pediatric pain management among nurses at the University of Gondar Comprehensive Specialized Hospital: A cross-sectional study
Authors: Lulie Endalew , Berhanu Mengistu , Kassa Selam Fisiha 
Published: February 2022

Introduction: Pain management is a very important aspect of nursing care. However, due to a lack of overall understanding, it is not uncommon to see inadequate pain management by health workers. Therefore, the knowledge and attitude of nurses are important factors for the effective management of pain in children. Thus, the objectives were to determine the knowledge and attitude toward pediatric pain management among the nurses in the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. Methods: An institutional-based cross-sectional study was conducted from 1 to 30 March 2020 among 393 participants. A simple random sampling technique was used to select the study subjects. The data were collected by using a structured, pre-tested, self-administered questionnaire. The data were entered into EpiData version 3.02 and exported into SPSS version 22 for analysis. Bivariable and multivariable logistic regressions were computed to identify the factors associated with the knowledge and attitude of nurses. An adjusted odds ratio with a 95% confidence interval was computed, and variables with a p-value < 0.05 in the multivariable analysis were used to declare the significance and strength of association. Result: A total of 267 (67.94%) of the respondents had good knowledge and 262 (66.7%) had a favorable attitude toward pediatric pain management. Working in the outpatient department (AOR = 0.48; 95% CI = 0.23–0.98) had a significant association with knowledge. Nurses who were trained (AOR = 2.47; 95% CI = 1.53–3.99), having good knowledge level (AOR = 2.16; 95% CI = 1.34–3.50), having 6–10 years of work experience (AOR = 2.64; 95% CI = 1.23–5.63), and >10 years of work experience (AOR = 9.02; 95% CI = 2.50–32.74) were significantly associated with the attitude toward pediatric pain management. Conclusion: The majority of nurses had good knowledge and a favorable attitude toward pediatric pain. Working in the outpatient department was associated with poor knowledge. Trained nurses, having good knowledge, and having >6 years of work experience were associated with favorable attitudes.
4-1BBL–containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells
Authors: Swatler Julian , Turos-Korgul Laura , Brewinska-Olchowik Marta , De Biasi Sara , Dudka Wioleta , Le Bac Viet , Kominek Agata , Cyranowski Salwador , Pilanc Paulina , Mohammadi Elyas , Cysewski Dominik , Kozlowska Ewa , Grabowska-Pyrzewicz Wioleta , Wojda Urszula , Basak Grzegorz , Mieczkowski Jakub , Skorski Tomasz , Cossarizza Andrea , Piwocka Katarzyna 
Published: February 2022

AbstractChronic and acute myeloid leukemia evade immune system surveillance and induce immunosuppression by expanding proleukemic Foxp3+ regulatory T cells (Tregs). High levels of immunosuppressive Tregs predict inferior response to chemotherapy, leukemia relapse, and shorter survival. However, mechanisms that promote Tregs in myeloid leukemias remain largely unexplored. Here, we identify leukemic extracellular vesicles (EVs) as drivers of effector proleukemic Tregs. Using mouse model of leukemia-like disease, we found that Rab27a-dependent secretion of leukemic EVs promoted leukemia engraftment, which was associated with higher abundance of activated, immunosuppressive Tregs. Leukemic EVs attenuated mTOR-S6 and activated STAT5 signaling, as well as evoked significant transcriptomic changes in Tregs. We further identified specific effector signature of Tregs promoted by leukemic EVs. Leukemic EVs-driven Tregs were characterized by elevated expression of effector/tumor Treg markers CD39, CCR8, CD30, TNFR2, CCR4, TIGIT, and IL21R and included 2 distinct effector Treg (eTreg) subsets: CD30+CCR8hiTNFR2hi eTreg1 and CD39+TIGIThi eTreg2. Finally, we showed that costimulatory ligand 4-1BBL/CD137L, shuttled by leukemic EVs, promoted suppressive activity and effector phenotype of Tregs by regulating expression of receptors such as CD30 and TNFR2. Collectively, our work highlights the role of leukemic extracellular vesicles in stimulation of immunosuppressive Tregs and leukemia growth. We postulate that targeting of Rab27a-dependent secretion of leukemic EVs may be a viable therapeutic approach in myeloid neoplasms.