bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personality-specific pathways from bullying victimization to adolescent alcohol use: a multilevel longitudinal moderated mediation analysis
Authors: Laroque Flavie M. , Boers Elroy , Afzali Mohammad H. , Conrod Patricia J. 
Published: February 2022

AbstractBullying victimization is common in adolescence and has been associated with a broad variety of psychopathology and alcohol use. The present study assessed time-varying associations between bullying victimization and alcohol use through internalizing and externalizing symptoms and whether this indirect association throughout time is moderated by personality. This 5-year longitudinal study (3,800 grade 7 adolescents) used Bayesian multilevel moderated mediation models: independent variable was bullying victimization; moderators were four personality dimensions (anxiety sensitivity, hopelessness, impulsivity, and sensation seeking); internalizing symptoms (anxiety, depressive symptoms) and externalizing symptoms (conduct, hyperactivity problems) were the mediators; and alcohol use, the outcome. Results indicated significant between, within, and lagged effects on alcohol use through internalizing and externalizing symptoms. There were significant between and within effects on alcohol use through internalizing symptoms for adolescents with high anxiety sensitivity and hopelessness, and significant between, within, and lagged effects on alcohol use through externalizing symptoms for adolescents with high impulsivity and sensation seeking. These findings implicate two risk pathways that account for how bullying victimization enhances alcohol use risk and emphasize the importance of personality profiles that can shape the immediate and long-term consequences of victimization.
IN DEFENSE OF THE STANDARD PICTURE: WHAT THE STANDARD PICTURE EXPLAINS THAT THE MORAL IMPACT THEORY CANNOT
Authors: Watson Bill 
Published: February 2022

ABSTRACTHow do legal texts determine legal content? A standard answer to this question—sometimes called “the standard picture”—is that legal texts communicate something and what they communicate is identical to legal content. Mark Greenberg criticizes the standard picture and offers in its place his own “moral impact theory.” My goal here is to respond to Greenberg by showing how the standard picture better explains legal practice than the moral impact theory does. To that end, I first clarify certain aspects of the moral impact theory. I then critique the theory, focusing on its inability to explain (i) why practitioners reason about legal content as they do and (ii) why they agree on legal content as often as they do. Finally, I refine the standard picture and demonstrate how it explains what the moral impact theory cannot.
The Tambourine, Joseph Dale's Grand Sonata and Its Role in the Appearance of Women Musicians in the Salon
Authors: Girling Sam 
Published: February 2022

By the turn of the nineteenth century composers such as Daniel Steibelt and Muzio Clementi were writing keyboard pieces with tambourine (and, occasionally, triangle) parts that were clearly intended for private salon performances by girls and young women. These works were introduced to public and private European salons during the early nineteenth century. Steibelt performed such pieces, typically waltzes, bacchanals, rondos and divertissements whilst on tour with his English wife Catherine, daughter of the London-based music publisher and patent tambourine manufacturer Joseph Dale. She became a renowned tambourine virtuoso, even attracting the attention of the Bohemian musician and writer Václav Jan Tomášek, who described the great sensation caused by Catherine's performances.I analyse different types of works that were written for the tambourine around the year 1800. Examples of short waltzes (which were usually published in sets of 6 or 12) are plentiful – they were by far the most common pieces written for piano and tambourine – and in them the historical link between the tambourine and dance is most obvious. I argue that these waltzes may have served as a bridging point between dance-like, energetic, social activities and passive, recreational drawing-room music. Further support for this idea can be found in a Grand Sonata for pianoforte, tambourine, flute, violin and basso by Joseph Dale. The tambourine part contains numerous choreographic instructions as well as a wide variety of playing techniques such as thumb rolls, bass notes and harmonics, the likes of which did not become common practice in the orchestral or chamber repertory until the twentieth century. Dale's intention was clearly to provide an opportunity for women musicians to express themselves in ways that were contrary to contemporary expectations of female social etiquette.
Boosting exposure and response prevention with imagery-based techniques: a case study tackling sexual obsessions in an adolescent
Authors: Lau-Zhu A. , Farrington A. , Bissessar C. 
Published: February 2022

Abstract
Sexual obsessions are common in adolescents with obsessive compulsive disorder (OCD), but how to address these obsessions in a developmentally sensitive manner remains under-explored. This report presents the case of an adolescent who experienced unwanted sexual imagery, undergoing conventional exposure and response prevention, which was subsequently augmented with imagery-based techniques. This approach was associated with remission in symptoms of OCD and marked improvements in symptoms of anxiety and depression. The imagery-based approach was well received and valued as key to treatment success by the adolescent. This raises the tantalising possibility that working directly with images can fuel treatment innovation in tackling sexual (and non-sexual) obsessions in youth OCD.

Key learning aims

(1)
Sexual obsessions are common in adolescent obsessive compulsive disorder (OCD).

(2)
Little guidance is available on how to conduct exposure and response prevention sensitively for sexual obsessions in adolescent OCD.

(3)
Imagery-based techniques can be used effectively for reducing sexual obsessions.

(4)
Imagery-based techniques delivered by videoconferencing can be acceptable for young people.
The Abundance of Trace Elements in Human Bone Relative to Bone Type and Bone Pathology
Authors: Coyte Rachel M. , Harkness Jennifer S. , Darrah Thomas H. 
Published: February 2022

AbstractAs the global population ages and the proportion of individuals afflicted with musculoskeletal disease spirals upward, there is an increasing interest in understanding and preventing bone‐related diseases. Bone diseases, such as osteoporosis and osteoarthritis, are known to be influenced by a variety of factors including age, gender, nutrition, and genetics, but are also inherently linked to the human body's ability to produce biominerals of suitable quality. Because the crystal lattice structure and mineralogy of bone hydroxyapatite is surprisingly analogous to geological hydroxyapatite, trace element levels and exposure have long been proposed to influence the structure of biominerals as they do geological minerals (e.g., strontium substitution changes the crystal lattice of bone minerals, while toxic lead disrupt bone cellular processes leading to bone disease). Here, we explore the distribution of trace elements in human bones to evaluate the distribution of these elements with respect to bone type (cortical vs. trabecular) and bone disease (osteoarthritis vs. osteoporosis). We find higher concentrations of many metabolically active transition metals, as well as lead, in cortical bone compared to trabecular bone. When compared to patients who have osteoarthritis, and thus presumably normal bone minerals, osteoporosis patients have higher concentrations of scandium and chromium (Cr) in trabecular bone, and Cr and lead in cortical bone. Lower concentrations of barium and titanium are associated with osteoporotic trabecular bone. This survey is an exploratory cross‐sectional geochemical examination of several trace element concentrations previously understudied in human bone minerals.
Evidence for de novo acquisition of microalgal symbionts by bleached adult corals
Authors: Scharfenstein Hugo J , Chan Wing Yan , Buerger Patrick , Humphrey Craig , van Oppen Madeleine J H 
Published: February 2022

Abstract
Early life stages of most coral species acquire microalgal endosymbionts (Symbiodiniaceae) from the environment, but whether exogenous symbiont uptake is possible in the adult life stage is unclear. Deep sequencing of the Symbiodiniaceae ITS2 genetic marker has revealed novel symbionts in adult corals following bleaching; however these strains may have already been present at densities below detection limits. To test whether acquisition of symbionts from the environment occurs, we subjected adult fragments of corals (six species in four families) to a chemical bleaching treatment (menthol and DCMU). The treatment reduced the native microalgal symbiont abundance to below 2% of their starting densities. The bleached corals were then inoculated with a cultured Cladocopium C1acro strain. Genotyping of the Symbiodiniaceae communities before bleaching and after reinoculation showed that fragments of all six coral species acquired the Cladocopium C1acro strain used for inoculation. Our results provide strong evidence for the uptake of Symbiodiniaceae from the environment by adult corals. We also demonstrate the feasibility of chemical bleaching followed by reinoculation to manipulate the Symbiodiniaceae communities of adult corals, providing an innovative approach to establish new symbioses between adult corals and heat-evolved microalgal symbionts, which could prove highly relevant to coral reef restoration efforts.
Comparison of early diabetic retinopathy staging in asymptomatic patients between autonomous AI-based screening and human-graded ultra-widefield colour fundus images
Authors: Sedova Aleksandra , Hajdu Dorottya , Datlinger Felix , Steiner Irene , Neschi Martina , Aschauer Julia , Gerendas Bianca S. , Schmidt-Erfurth Ursula , Pollreisz Andreas 
Published: February 2022

Abstract
Introduction
Comparison of diabetic retinopathy (DR) severity between autonomous Artificial Intelligence (AI)-based outputs from an FDA-approved screening system and human retina specialists’ gradings from ultra-widefield (UWF) colour images.

Methods
Asymptomatic diabetics without a previous diagnosis of DR were included in this prospective observational pilot study. Patients were imaged with autonomous AI (IDx-DR, Digital Diagnostics). For each eye, two 45° colour fundus images were analysed by a secure server-based AI algorithm. UWF colour fundus imaging was performed using Optomap (Daytona, Optos). The International Clinical DR severity score was assessed both on a 7-field area projection (7F-mask) according to the early treatment diabetic retinopathy study (ETDRS) and on the total gradable area (UWF full-field) up to the far periphery on UWF images.

Results
Of 54 patients included (n = 107 eyes), 32 were type 2 diabetics (11 females). Mean BCVA was 0.99 ± 0.25. Autonomous AI diagnosed 16 patients as negative, 28 for moderate DR and 10 for having a vision-threatening disease (severe DR, proliferative DR, diabetic macular oedema). Based on the 7F-mask grading with the eye with the worse grading defining the DR stage 23 patients were negative for DR, 11 showed mild, 19 moderate and 1 severe DR. When UWF full-field was analysed, 20 patients were negative for DR, while the number of mild, moderate and severe DR patients were 12, 21, and 1, respectively.

Conclusions
The autonomous AI-based DR examination demonstrates sufficient accuracy in diagnosing asymptomatic non-proliferative diabetic patients with referable DR even compared to UWF imaging evaluated by human experts offering a suitable method for DR screening.
Observation-dependent suppression and enhancement of two-photon coincidences by tailored losses
Authors: Ehrhardt Max , Heinrich Matthias , Szameit Alexander 
Published: February 2022

AbstractThe ability of indistinguishable particles to interfere with one another is a core principle of quantum mechanics. The interplay of interference and particles exchange statistics1–4 gives rise to the Hong–Ou–Mandel (HOM) effect5, where the bunching of bosons suppresses two-particle coincidences between the output ports of a balanced beamsplitter. Conversely, fermionic anti-bunching can yield up to a twofold enhancement of coincidences compared to the baseline of distinguishable particles. As such, the emergence of dips or peaks in the HOM effect may appear indicative of the particles’ bosonic/fermionic nature. Here, we demonstrate experimentally that the coincidence statistics of boson pairs can be seamlessly tuned from full suppression to enhancement by an appropriate choice of the observation basis. Our photonic setting leverages birefringent couplers6 to introduce differential dissipation in the photons’ polarization. In contrast to previous work7–9, the mechanism underpinning this unusual behaviour does not act on individual phases accumulated by pairs of particles along specific paths, but instead allows them to jointly evade losses as indistinguishable photons are prevented from inhabiting orthogonal modes. Our findings reveal a new approach to harnessing non-Hermitian settings for the manipulation of multi-particle quantum states and as functional elements in quantum simulation.
Long-term cardiovascular outcomes of COVID-19
Authors: Xie Yan , Xu Evan , Bowe Benjamin , Al-Aly Ziyad 
Published: February 2022

AbstractThe cardiovascular complications of acute coronavirus disease 2019 (COVID-19) are well described, but the post-acute cardiovascular manifestations of COVID-19 have not yet been comprehensively characterized. Here we used national healthcare databases from the US Department of Veterans Affairs to build a cohort of 153,760 individuals with COVID-19, as well as two sets of control cohorts with 5,637,647 (contemporary controls) and 5,859,411 (historical controls) individuals, to estimate risks and 1-year burdens of a set of pre-specified incident cardiovascular outcomes. We show that, beyond the first 30 d after infection, individuals with COVID-19 are at increased risk of incident cardiovascular disease spanning several categories, including cerebrovascular disorders, dysrhythmias, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure and thromboembolic disease. These risks and burdens were evident even among individuals who were not hospitalized during the acute phase of the infection and increased in a graded fashion according to the care setting during the acute phase (non-hospitalized, hospitalized and admitted to intensive care). Our results provide evidence that the risk and 1-year burden of cardiovascular disease in survivors of acute COVID-19 are substantial. Care pathways of those surviving the acute episode of COVID-19 should include attention to cardiovascular health and disease.
Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler
Authors: Noack Florian , Vangelisti Silvia , Raffl Gerald , Carido Madalena , Diwakar Jeisimhan , Chong Faye , Bonev Boyan 
Published: February 2022

AbstractHow multiple epigenetic layers and transcription factors (TFs) interact to facilitate brain development is largely unknown. Here, to systematically map the regulatory landscape of neural differentiation in the mouse neocortex, we profiled gene expression and chromatin accessibility in single cells and integrated these data with measurements of enhancer activity, DNA methylation and three-dimensional genome architecture in purified cell populations. This allowed us to identify thousands of new enhancers, their predicted target genes and the temporal relationships between enhancer activation, epigenome remodeling and gene expression. We characterize specific neuronal transcription factors associated with extensive and frequently coordinated changes across multiple epigenetic modalities. In addition, we functionally demonstrate a new role for Neurog2 in directly mediating enhancer activity, DNA demethylation, increasing chromatin accessibility and facilitating chromatin looping in vivo. Our work provides a global view of the gene regulatory logic of lineage specification in the cerebral cortex.
Retroviral infection of human neurospheres and use of stem Cell EVs to repair cellular damage
Authors: Branscome Heather , Khatkar Pooja , Al Sharif Sarah , Yin Dezhong , Jacob Sheela , Cowen Maria , Kim Yuriy , Erickson James , Brantner Christine A. , El-Hage Nazira , Liotta Lance A. , Kashanchi Fatah 
Published: February 2022

AbstractHIV-1 remains an incurable infection that is associated with substantial economic and epidemiologic impacts. HIV-associated neurocognitive disorders (HAND) are commonly linked with HIV-1 infection; despite the development of combination antiretroviral therapy (cART), HAND is still reported to affect at least 50% of HIV-1 infected individuals. It is believed that the over-amplification of inflammatory pathways, along with release of toxic viral proteins from infected cells, are primarily responsible for the neurological damage that is observed in HAND; however, the underlying mechanisms are not well-defined. Therefore, there is an unmet need to develop more physiologically relevant and reliable platforms for studying these pathologies. In recent years, neurospheres derived from induced pluripotent stem cells (iPSCs) have been utilized to model the effects of different neurotropic viruses. Here, we report the generation of neurospheres from iPSC-derived neural progenitor cells (NPCs) and we show that these cultures are permissive to retroviral (e.g. HIV-1, HTLV-1) replication. In addition, we also examine the potential effects of stem cell derived extracellular vesicles (EVs) on HIV-1 damaged cells as there is abundant literature supporting the reparative and regenerative properties of stem cell EVs in the context of various CNS pathologies. Consistent with the literature, our data suggests that stem cell EVs may modulate neuroprotective and anti-inflammatory properties in damaged cells. Collectively, this study demonstrates the feasibility of NPC-derived neurospheres for modeling HIV-1 infection and, subsequently, highlights the potential of stem cell EVs for rescuing cellular damage induced by HIV-1 infection.
Sonication-supported synthesis of cobalt oxide assembled on an N-MWCNT composite for electrochemical supercapacitors via three-electrode configuration
Authors: Nare Rajendra Kumar , Ramesh Sivalingam , Basavi Praveen Kumar , Kakani Vijay , Bathula Chinna , Yadav Hemraj M. , Dhanapal Prakash Babu , Kotanka Rama Krishna Reddy , Pasupuleti Visweswara Rao 
Published: February 2022

AbstractThe Co3O4@N-MWCNT composite was synthesized by a sonication-supported thermal reduction process for supercapacitor applications. The structural and morphological properties of the materials were characterized via Raman, XRD, XPS, SEM–EDX, and FE-TEM analysis. The composite electrode was constructed into a three-electrode configuration and examined by using CV, GCD and EIS analysis. The demonstrated electrochemical value of ~ 225 F/g at 0.5 A/g by the electrode made it appropriate for potential use in supercapacitor applications.
KLRK1 as a prognostic biomarker for lung adenocarcinoma cancer
Authors: Zhang Yanan , Chen Zeyang , Jiang Aifang , Gao Guanqi 
Published: February 2022

AbstractLung cancer is one of the most common malignancy worldwide and causes estimated 1.6 million deaths each year. Cancer immunosurveillance has been found to play an important role in lung cancer and may be related with its prognosis. KLRK1, encoding NKG2D, is a homodimeric lectin-like receptor. However, there has not been one research of KLRK1 as a biomarker in lung cancer. Data including patients` clinical characteristics and RNAseq information of KLRK1 from TCGA were downloaded. A total of 1019 patients with lung cancer were included in this study, among which 407 patients were female and 611 patients were male. Evaluations of mRNA expression, diagnostic value by ROC (receiver operating characteristic) curves and prognostic value by survival curve, Cox model and subgroup analysis were performed. The level of KLRK1 expression in lung adenocarcinoma cancer tissues and normal lung tissues was detected by qRT-PCR. The CCK-8 assay investigated the proliferation rate and the wound healing assay assessed the migratory ability in vitro. The expression of KLRK1 in tumor was lower than that in normal tissue. KLRK1 expression was associated with gender, histologic grade, stage, T classification and vital status. Patients with high KLRK1 expression presented an improved overall survival (P = 0.0036) and relapse free survival (P = 0.0031). KLRK1 was found to have significant prognostic value in lung adenocarcinoma (P = 0.015), stage I/II (P = 0.03), older patients (P = 0.0052), and male (P = 0.0047) by subgroup overall survival analysis, and in lung adenocarcinoma (P = 0.0094), stage I/II (P = 0.0076), older patients (P = 0.0072), and male (P = 0.0033) by subgroup relapse free survival analysis. Lung adenocarcinoma cancer patients with high KLRK1 expression presented an improved overall survival (P = 0.015) and relapse free survival (P = 0.0094). In vitro studies indicated that KLRK1 inhibited tumor cell proliferation and migration. KLRK1 was an independent prognostic factor and high KLRK1 expression indicated a better overall and relapse free survival. KLRK1 may be a prognostic biomarker for lung adenocarcinoma cancer.
Study on landscape evaluation and optimization strategy of Central Park in Qingkou Town
Authors: Xiang Lingyan , Tian Yunqing , Pan Yucong 
Published: February 2022

AbstractThis article mainly discusses the evaluation and optimization of the green space utilization value of comprehensive parks used by people in dense urban areas based on the desire for green and healthy living in the postepidemic era. As a qualitative study of urban parks, this study builds an evaluation system based on the American landscape performance series and combines it with comprehensive indicators of China’s urban parks, including environmental performance (such as park planning, infrastructure, trails, and vegetation), health performance (such as cultural education, park activities, and transportation accessibility) economic performance (such as tourist consumption and stimulating the development of surrounding construction) and three other aspects: conducting a site evaluation; evaluating observed behavior, interviews and questionnaires; and performing the analytic hierarchy process–coefficient of variation weight comprehensive evaluation analysis. Additionally, the park comprehensive index, land use index, traffic convenience, park vitality index and other dynamic changes are analyzed over time. The purpose is to explore the foundation of urban parks after the epidemic. The role of the urban park environment in sustainable ecological development is verified, and appropriate optimization and improvement actions are determined.