bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noninvasive Evaluation of the Notch Signaling Pathway via Radiomic Signatures Based on Multiparametric MRI in Association With Biological Functions of Patients With Glioma: A Multi‐institutional Study
Authors: Shen Nanxi , Lv Wenzhi , Li Shihui , Liu Dong , Xie Yan , Zhang Ju , Zhang Jiaxuan , Jiang Jingjing , Jiang Rifeng , Zhu Wenzhen 
Published: August 2022

BackgroundNoninvasive determination of Notch signaling is important for prognostic evaluation and therapeutic intervention in glioma.PurposeTo predict Notch signaling using multiparametric (mp) MRI radiomics and correlate with biological characteristics in gliomas.Study TypeRetrospective.PopulationA total of 63 patients for model construction and 47 patients from two public databases for external testing.Field Strength/SequenceA 1.5 T and 3.0 T, T1‐weighted imaging (T1WI), T2WI, T2 fluid attenuated inversion recovery (FLAIR), contrast‐enhanced (CE)‐T1WI.AssessmentRadiomic features were extracted from CE‐T1WI, T1WI, T2WI, and T2FLAIR and imaging signatures were selected using a least absolute shrinkage and selection operator. Diagnostic performance was compared between single modality and a combined mpMRI radiomics model. A radiomic–clinical nomogram was constructed incorporating the mpMRI radiomic signature and Karnofsky Performance score. The performance was validated in the test set. The radiomic signatures were correlated with immunohistochemistry (IHC) analysis of downstream Notch pathway components.Statistical TestsReceiver operating characteristic curve, decision curve analysis (DCA), Pearson correlation, and Hosmer–Lemeshow test. A P value < 0.05 was considered statistically significant.ResultsThe radiomic signature derived from the combination of all sequences numerically showed highest area under the curve (AUC) in both training and external test sets (AUCs of 0.857 and 0.823). The radiomics nomogram that incorporated the mpMRI radiomic signature and KPS status resulted in AUCs of 0.891 and 0.859 in the training and test sets. The calibration curves showed good agreement between prediction and observation in both sets (P= 0.279 and 0.170, respectively). DCA confirmed the clinical usefulness of the nomogram. IHC identified Notch pathway inactivation and the expression levels of Hes1 correlated with higher combined radiomic scores (r = −0.711) in Notch1 mutant tumors.Data ConclusionThe mpMRI‐based radiomics nomogram may reflect the intratumor heterogeneity associated with downstream biofunction that predicts Notch signaling in a noninvasive manner.Evidence Level3Technical EfficacyStage 2
Placement of catheters without magnetic sensors in the coronary sinus without fluoroscopic guidance: Feasibility and safety evaluation
Authors: Hoshiyama Tadashi , Sumi Hitoshi , Kaneko Shozo , Kawahara Yusei , Ito Miwa , Kanazawa Hisanori , Takashio Seiji , Yamamoto Eiichiro , Matsushita Kenichi , Tsujita Kenichi 
Published: August 2022

AbstractBackgroundA three‐dimensional (3D) mapping system is essential to reduce radiation exposure during catheter ablation. When using the CARTO 3D mapping system, only the catheter with magnetic sensor can visualize its location. However, once target chamber matrix is created using the catheter, even the catheters without magnetic sensors (CWMS) can enable visualization. We aimed to investigate the feasibility and safety of placing a CWMS in the coronary sinus (CS) without fluoroscopic guidance.MethodsThe study group comprised 88 consecutive patients who underwent catheter ablation. CWMS placement was performed without fluoroscopic guidance in 47 patients and with fluoroscopic guidance in 41 patients. Placement without fluoroscopic guidance was performed after creating a visualization matrix of the CS, right atrium, and superior vena cava using a catheter with a magnetic sensor. Feasibility and safety were compared between the two groups.ResultsSuccessful catheter placement was achieved in all patients without fluoroscopic guidance, with no inter‐group difference in the median procedure time: with guidance, 120.0 [96.0–135.0] min, and without guidance, 110.0 [97.5–125.0] min; p = .22. However, radiation exposure was significantly shorter, and the effective dose was lower without fluoroscopic guidance (0 [0–17.5] s and 0 [0–0.004] mSv, respectively) than with fluoroscopic guidance (420.0 [270.0–644.0] s and 0.73 mSv [0.36–1.26], respectively); both p < .001.ConclusionsCWMS placement without fluoroscopic guidance is feasible, safe to perform, and does not involve complications. Our technique provides an option to decrease radiation exposure during catheter ablation and electrophysiological testing.
In‐Hospital Costs for Open versus Endoscopic Endonasal Approach for Craniopharyngioma Resection
Authors: Parasher Arjun K , Lerner David K , Miranda Stephen P. , Douglas Jennifer E. , Glicksman Jordan T , Alexander Tyler , Lin Theodore , Ebesutani Darren , Kohanski Michael , Lee John YK , Storm Phillip B , O'Malley Bert W , Yoshor Daniel , Palmer James N , Grady M Sean , Adappa Nithin D 
Published: August 2022

ObjectiveTo determine the in‐hospital cost implications of an expanded endoscopic endonasal approach (EEEA) for craniopharyngioma resection relative to the traditional open transcranial approach.MethodsAll craniopharyngioma surgeries performed at a single institution over a period from January 1st 2001 to October 31th 2017 were evaluated. The electronic medical record was reviewed for patient factors, tumor characteristics, and cost variables associated with each hospital stay and univariate regression analysis was performed using R software.ResultsThirty‐six patients met study criteria, including 22 undergoing an open approach and 14 undergoing an EEEA. There was a significantly longer average length of stay among patients undergoing open resection (21.5 vs. 10.6 days, p = 0.024). The average total in‐hospital cost of a patient undergoing an EEEA was $58979.3 compared to $89142.3 for an open approach (p = 0.127). On univariate regression analysis, the total in‐hospital cost for a patient undergoing an open approach relative to an EEEA was $30163.0 (p = 0.127). The open approach was exclusively performed from study onset until April 2010 (16 patients). From April 2010 to August 2013, 6 open approaches and 5 EEEA were performed. The EEEA has been exclusively performed from August 2013 until the conclusion of our study period (9 patients).ConclusionsThere has been a shift toward surgical resection of craniopharyngioma via an EEEA approach for amenable tumors. Our study demonstrates that the EEEA has become the preferred surgical approach at our institution, and shows that the EEEA is associated with shorter postoperative length of stay and lower total in‐hospital cost. Laryngoscope, 133:83–87, 2023
pH‐Responsive Charge‐Convertible N‐Succinyl Chitosan‐Quercetin Coordination Polymer Nanoparticles for Effective NIR Photothermal Cancer Therapy
Authors: Bhartiya Prabha , Chawla Ruchi , Dutta Pradip K. 
Published: August 2022

AbstractIn recent years, a combination of photothermal therapy (PTT) with chemotherapy has emerged as a new promising strategy to achieve synergistic cancer therapeutic efficacy. Coordination polymer nanocomposites (CPNs) are a new generation of photothermal agents (PTAs) for cancer therapy owing to their high photothermal transduction efficiency, excellent biocompatibility as well as biodegradability and bioactivity. In this study, a robust and scalable synthesis of pH‐sensitive charge convertible NSC‐Fe‐Que coordination polymer nanoparticles (CPNs) based on the coordination reaction between Fe3+, anti‐cancer prodrug quercetin (Que), and pH‐sensitive zwitterionic biopolymer N‐succinyl chitosan (NSC) is reported. The as‐prepared CPNs exhibit slightly negative zeta potential at neutral pH while positive zeta potential at pH 6.5, which ensures long blood circulation and high accumulation in the tumor region. NSC‐Fe‐Que CPNs exhibited strong absorption in NIR (500–850 nm) region and displayed a good anticancer effect against A549 cells attributing to the chemo‐photothermal synergistic effect. This study demonstrated that the NSC‐Fe‐Que CPNs hold great promise as an effective thermo‐chemotherapy agent for combination therapy against cancer.
Atypical presentation of Angelman syndrome with intact expressive language due to low‐level mosaicism
Authors: Punatar Ruchi , Egense Alena , Mao Rong , Procter Melinda , Bosworth Michelle , Quigley Denise I. , Angkustsiri Kathleen , Shankar Suma P. 
Published: August 2022

AbstractBackgroundAngelman syndrome (AS) occurs due to a lack of expression or function of the maternally inherited UBE3A gene. Individuals with AS typically have significant developmental delay, severe speech impairment with absent to minimal verbal language, gait abnormalities including ataxia, and an incongruous happy demeanor. The majority of individuals with AS also have seizures and microcephaly. Some individuals with mosaic AS have been reported to have expressive language and milder levels of developmental delay.Case ReportWe report a male patient presenting with mild to moderate intellectual disability, hyperphagia, obesity, and the ability to communicate verbally. His phenotype was suggestive of Prader‐Willi syndrome. However, methylation testing was positive for Angelman syndrome and additional methylation specific multiplex ligation‐dependent amplification (MS‐MLPA) study revealed low‐level mosaicism for AS.ConclusionA broader phenotypic spectrum should be considered for AS as patients with atypical presentations may otherwise elude diagnosis.
Single‐step post‐production treatment of lead acetate precursor‐based perovskite using alkylamine salts for reduced grain‐boundary related film defects
Authors: Gebremichael Zekarias Teklu , Alam Shahidul , Stumpf Steffi , Diegel Marco , Schubert Ulrich S. , Hoppe Harald 
Published: August 2022

AbstractPowered by the worldwide efforts of research groups experienced in dye‐sensitized, and thin‐film solar cells, perovskite solar cells (PSCs) reached a power conversion efficiency of 25.7% within 10 years. However, the presence of defects and trap density within the active layer's grain boundaries commonly operates as non‐radiative recombination centers. Hence, intensive efforts have been reported to passivate the inevitable bulk and interface defects of the active layer using additives or post‐treatment processing to enhance the efficiency and stability of PSCs. Herein, a facile post‐treatment strategy based on wet processing methylammonium lead triiodide, MAPbI3 (prepared from lead acetate and methylammonium iodide precursors) films with organic amine salts (FABr and FAI) is demonstrated. As a result, high‐quality films of mixed perovskites (FAxMA1‐xPbI3‐xBrx and FAxMA1‐xPbI3) were obtained. The surface treatment has efficiently passivate the defects in the host film, suppressing the non‐radiative carrier recombination. Compared to the control device, the increased open‐circuit voltage (from 0.5 V to 1 V) and fill factor (FF) values of the optimized device based on FAxMA1‐xPbI3 showed a PCE of 16.13%. And our findings revealed that post‐treatment is possible on wet perovskite film aged for a few minutes prior to its post‐treatment, which saved the energy used for pre‐annealing.
Association of prepregnancy physical activity with obesity in offspring: The Japan Environment and Children's Study
Authors: Noda Masahiro , Yoshida Satomi , Kawakami Chihiro , Takeuchi Masato , Kawakami Koji , Ito Shuichi ,   Japan Environment and Children's Study Group
Published: August 2022

AbstractObjectiveThe aim of this study was to investigate the association between maternal prepregnancy physical activity (PA) and overweight/obesity in 3‐year‐old children.MethodsUsing data from the Japan Environment and Children's Study (a birth cohort study), maternal prepregnancy PA was categorized into low, moderate, and high with the International Physical Activity Questionnaire (IPAQ). The reference group was defined as children born to mothers with moderate PA. The association between prepregnancy PA and overweight/obesity or obesity in children was investigated using univariable and multivariable logistic regression analyses.ResultsOf the 65,245 participants, 48.7%, 32.7%, and 18.6% were born to mothers in the low, moderate, and high PA groups, respectively. Furthermore, 24.9%, 24.6%, and 25.9% of children with overweight/obesity and 9.4%, 9.2%, and 10.4% of children with obesity were born to mothers in the low, moderate, and high PA groups, respectively. The adjusted odds ratios for overweight/obesity in the low and high PA groups were 1.02 (95% CI: 0.98‐1.06) and 1.04 (95% CI: 0.98‐1.09), and those for obesity were 1.03 (95% CI: 0.97‐1.09) and 1.08 (95% CI: 0.99‐1.16), respectively.ConclusionsMaternal prepregnancy PA was not associated with overweight/obesity or obesity in 3‐year‐old children.
Perceived intrinsic, social, and environmental barriers for weight management in older Hispanic/Latino adults with obesity
Authors: Dao Maria Carlota , Yu Zihan , Maafs‐Rodríguez Ana , Moser Brandy , Cuevas Adolfo G. , Economos Christina D. , Roberts Susan B. 
Published: August 2022

AbstractBackgroundThe burden of obesity and chronic disease is increasing in the older US Hispanic/Latino adult population. There is limited evidence on successful weight management strategies as perceived by this population. Assessing barriers and opportunities for weight management using mixed methods is a robust approach to collect in‐depth information that can be applied to the development of well‐tailored weight management interventions for this population.ObjectiveThe objective of this study was to assess perceived individual, interpersonal, and environmental factors that influence weight management in older Hispanic/Latino adults.MethodsThis community‐based cross‐sectional study included 23 Hispanic/Latino older (>50y) adults with obesity (BMI >30 kg/m2). Perceived barriers and opportunities for weight management were assessed through validated questionnaires and focus groups. Prospectively registered on ClinicalTrials.gov (NCT03978416) on 7 June 2019.ResultsIn this demographically heterogeneous population, language acculturation was generally low, and the frequency of poor dietary behaviors was high. Participants linked financial strain to lower diet quality, as well as anxiety to uncontrolled eating and food cravings. Social support and trust in healthcare professionals were perceived as priorities for healthy eating. Structural and environmental barriers such as affordability and availability of culturally preferred foods were also identified as influences on food choices and eating behavior.ConclusionsThis study revealed opportunities for culturally tailored weight management interventions in older Hispanic/Latino adults with obesity.Clinical Trial Registry NumberNCT03978416 (ClinicalTrials.gov)
Fifty years of capacity building: Taking stock and moving research forward1
Authors: Kacou Kablan P. , Ika Lavagnon A. , Munro Lauchlan T. 
Published: August 2022

AbstractThis paper assesses the literature on “capacity building” through a systematic literature review. Taking concepts as the ontological building blocks of theories, we ask: what is known about the evolution of capacity building as a concept and what can that history tell us about its strengths and weaknesses? To this end, we dig into the conceptual and theoretical underpinnings of capacity building. Through this Foucauldian “archaeological description”, we show that capacity building discourse has evolved dialectically, with each new concept emerging to address the failings of earlier concepts. The paper suggests the “new pragmatism” as a theoretical framework to guide a more rigorous and relevant theory and practice of capacity building especially for public administration. Rooted in sensitivity to context and methodological pluralism, the new pragmatism embraces complexity, delivers “best‐fit” rather than “best practice” solutions, and involves researchers and practitioners in decolonial knowledge co‐creation to tackle capacity building challenges.
Evaluation of tensile properties on glass/carbon fiber epoxy pure, interply, and locally nested intraply hybrid composites
Authors: Tüzemen Mehmet Çağrı 
Published: August 2022

AbstractIn this study, the behavior of pure glass fiber/epoxy, pure carbon fiber/epoxy, interply hybrid, and locally nested intraply hybrid composites under tensile load was investigated. The specimens were produced by the vacuum‐assisted resin transfer molding (VARTM) method. Interply hybrid composites showed approximately the average tensile strength of the glass and carbon fiber/epoxy composites, with 603 MPa. Intraply hybrid composites had 17% lower tensile strength than pure glass fiber/epoxy composites due to the discontinuity of the fibers in the structure. Therefore, pure or interply hybrid composites are suitable in cases where tensile strength is more important, while in special cases where different properties are desired in different regions of a monolithic structure, locally nested intraply hybrid composites can be used. While the finite element analysis (FEA) results of pure and interply hybrid composites were very close to the tensile test, the amount of deviation increased in intraply hybrid composites due to fiber discontinuity. Fiber and void volume fractions of hybrid specimens were found to be around 62% and 1.45%, respectively. The numerical and experimental results of pure carbon fiber/epoxy composite are validated by the analytical solution.
The prenatal and postnatal effects of air pollution on asthma in children with atopic dermatitis
Authors: Chen I‐Lun , Chung Hao‐Wei , Hsieh Hui‐Min , Chen Szu‐Chia , Chen Huang‐Chi , Lin Yi‐Ching , Hung Chih‐Hsing 
Published: August 2022

AbstractObjectivesAir pollution is strongly associated with asthma, but has not been determined to induce new‐onset asthma development in children with atopic dermatitis (AD).Working HypothesisTo assess whether prenatal/postnatal exposure to air pollutants triggers new‐onset asthma development in children with AD.Study DesignRetrospective cohort study.Patient‐subject SelectionData of patients <age 18 years diagnosed with eczema or AD between 2009 and 2019 were extracted from the multicenter Kaohsiung Medical University Hospital Research Database. Patients diagnosed with new‐onset asthma were in the asthma group and patients without asthma history were in the non‐asthma group.MethodologyThe monthly average concentration of air pollutants for 1, 3, and 5 years before the index date, and 3, 6, and 9 months prenatally were analyzed and further stratified by age, immunoglobulin (Ig) E, and the percentage of eosinophil and eosinophil cationic protein (ECP).ResultsPostnatal exposure to airborne particulate matter (PM2.5, PM10), sulfur dioxide (SO2), ozone (O3), carbon monoxide (CO), nitric oxide (NO), nitric dioxide (NO2), and NOx, and prenatal exposure to PM2.5, PM10, SO2, NO, and NOx were significantly higher in the asthma group than in the non‐asthma group. Patients having IgE above 100 IU/ml and ECP less than 24 ng/ml were significantly influenced by postnatal exposure to PM2.5 and PM10, especially CO, to develop asthma, and those having an eosinophil count >3% were significantly influenced by prenatal exposure to PM2.5, especially SO2, NO, and NO2.ConclusionsPrenatal and postnatal exposure to air pollution have an association with asthma development in AD patients.
Plasma biomarkers for systemic inflammation in COVID‐19 survivors
Authors: Zhao Juan , Schank Madison , Wang Ling , Dang Xindi , Cao Dechao , Khanal Sushant , Nguyen Lam N.T. , Zhang Yi , Wu Xiao Y. , Adkins James L. , Pelton Benjamin J. , Zhang Jinyu , Ning Shunbin , Gazzar Mohamed El , Moorman Jonathan P. , Yao Zhi Q. 
Published: August 2022

AbstractBackgroundWhile the majority of COVID‐19 patients fully recover from the infection and become asymptomatic, a significant proportion of COVID‐19 survivors experience a broad spectrum of symptoms lasting weeks to months post‐infection, a phenomenon termed “post‐acute sequelae of COVID‐19 (PASC).” The aim of this study is to determine whether inflammatory proteins are dysregulated and can serve as potential biomarkers for systemic inflammation in COVID‐19 survivors.MethodsWe determined the levels of inflammatory proteins in plasma from 22 coronavirus disease 2019 (COVID‐19) long haulers (COV‐LH), 22 COVID‐19 asymptomatic survivors (COV‐AS), and 22 healthy subjects (HS) using an Olink proteomics assay and assessed the results by a beads‐based multiplex immunoassay.ResultsCompared to HS, we found that COVID‐19 survivors still exhibited systemic inflammation, as evidenced by significant changes in the levels of multiple inflammatory proteins in plasma from both COV‐LH and COV‐AS. CXCL10 was the only protein that significantly upregulated in COV‐LH compared with COV‐AS and HS.ConclusionsOur results indicate that several inflammatory proteins remain aberrantly dysregulated in COVID‐19 survivors and CXCL10 might serve as a potential biomarker to typify COV‐LH. Further characterization of these signature inflammatory molecules might improve the understanding of the long‐term impacts of COVID‐19 and provide new targets for the diagnosis and treatment of COVID‐19 survivors with PASC.
Mother's iliac bone graft for severe collapsed lumbar tuberculosis: A case report
Authors: You Yonggang , Chen Suli , Li Zhanqing , Zhang Yuanwen , Qiu Wenpeng 
Published: August 2022

AbstractEarly diagnosis of spinal tuberculosis in young children is difficult due to atypical clinical features. We report a case of lumbar tuberculosis with abscess of the psoas major muscle in a 4‐year‐old child. Spinal reconstruction was challenging due to the involvement of multiple vertebral levels. The child complained of lumbar and back pain. Preoperative magnetic resonance imaging (MRI) revealed bone destruction of the L1–L3 vertebral body and abscess formation of the psoas major muscle. The child underwent excision of the vertebral lesions and a fresh iliac bone graft from his mother through an anterior approach and posterior fixation with T12–L1 and L4–L5 pedicle screws. At the 15‐month follow‐up, the patient had good clinico‐radiologic outcomes with evidence of bony fusion. No functional impairment of lumbar movements was found through physical examination during the follow‐up period. The report highlights the diagnostic dilemma of early childhood spinal tuberculosis due to lesions seen both on radiology and during surgery and discusses challenges in management of the disease and the relevant literature. The mother's iliac bone graft we describe can be a viable option in very young children with severe vertebral bone destruction requiring reconstruction by surgical procedure.