bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simulation study on the association of HRO communication patterns and surgical team performance
Authors: Baty Amanda , Matis Timothy I , Griswold John 
Published: April 2022

Abstract

Background
The hallmarks of high-reliability organizations (HROs) have been broadly embraced by health-care organizations as a path to achieve greater reliability in patient care. A simulation study was conducted to investigate the hypothesis that surgical teams whose intraoperative communication displayed the HRO hallmarks had a greater capacity to detect and resolve surgical complications in less time.

Methods
The study consisted of presenting four simulations to five surgical teams using a within-subject experimental design. In each simulation, the patient would manifest a complication in which the detection and/or resolution was either obscure or obvious. Communication patterns related to the frequency and sustained duration of HRO content were extracted from coded transcripts using recurrence quantification analysis (RQA), which were paired with the teams’ elapsed time to detect or resolve a surgical complication. Spearman’s rank-order statistics was then used to test for a monotonically decreasing association between these variables.

Results
Data consisting of the RQA metrics and elapsed times are reported for each surgical team in each simulation in addition to statistical tests for association between these variables and inter-rater reliability statistics of the coded communication.

Conclusions
The study suggests that surgical teams whose communication espouses the HRO hallmarks of commitment to resilience and deference to expertise in both frequency and duration are able to resolve surgical complications with an obscure corrective action in less time. The study did not provide confirming evidence that these are associated with their ability to resolve a complication with an obvious corrective action in less time or that patterns of sensitivity to operations are associated with their ability to detect an obscure surgical complication in less time.
Spatial Audio for Multimodal Location Monitoring
Authors: Marentakis Georgios 
Published: April 2022

Abstract
Location monitoring is a common task that is typically performed using visual displays that may constrain user location and visual attention. Using spatial audio to present the location of the monitored target could help relax such constraints. To evaluate this hypothesis, we conducted three experiments in which the location monitoring display modality, location, cognitive load and the task spatial resolution were varied. Visual and audiovisual location monitoring resulted in a higher location monitoring accuracy and speed but it induced a significantly higher dual-task cost compared to auditory when both displays were not within peripheral vision. Furthermore, auditory location monitoring accuracy approximated visual when the spatial resolution required by the task was adapted to auditory localization accuracy. The results show that using spatial audio to create multimodal location monitoring can reduce visual attention load and increase the flexibility of user placement relative to the monitoring display without incurring an additional location monitoring cost.
Existential Aesthetics
Authors: Maes Hans 
Published: April 2022

Abstract
The aim of what I propose to call “existential aesthetics” is to investigate the various ways in which art and certain kinds of aesthetic practice or aesthetic experience can be of existential importance to people. Section I provides a definition of existential aesthetics, while Section II delineates this emerging field from cognate areas of research. Sections III and IV explore various subcategories and examples of existential aesthetics. Section V seeks to identify important avenues for future research and Section VI presents some concluding thoughts about the potential of existential aesthetics and why philosophers should be encouraged to fulfill this potential.
Whole genome sequencing-based drug resistance predictions of multidrug-resistant Mycobacterium tuberculosis isolates from Tanzania
Authors: Mbelele Peter M. , Utpatel Christian , Sauli Elingarami , Mpolya Emmanuel A. , Mutayoba Beatrice K. , Barilar Ivan , Dreyer Viola , Merker Matthias , Sariko Margaretha L. , Swema Buliga M. , Mmbaga Blandina T. , Gratz Jean , Addo Kennedy K. , Pletschette Michel , Niemann Stefan , Houpt Eric R. , Mpagama Stellah G. , Heysell Scott K. 
Published: April 2022

Abstract

Background
Rifampicin- or multidrug-resistant (RR/MDR) Mycobacterium tuberculosis complex (MTBC) strains account for considerable morbidity and mortality globally. WGS-based prediction of drug resistance may guide clinical decisions, especially for the design of RR/MDR-TB therapies.

Methods
We compared WGS-based drug resistance-predictive mutations for 42 MTBC isolates from MDR-TB patients in Tanzania with the MICs of 14 antibiotics measured in the Sensititre™ MycoTB assay. An isolate was phenotypically categorized as resistant if it had an MIC above the epidemiological-cut-off (ECOFF) value, or as susceptible if it had an MIC below or equal to the ECOFF.

Results
Overall, genotypically non-wild-type MTBC isolates with high-level resistance mutations (gNWT-R) correlated with isolates with MIC values above the ECOFF. For instance, the median MIC value (mg/L) for rifampicin-gNWT-R strains was &gt;4.0 (IQR 4.0–4.0) compared with 0.5 (IQR 0.38–0.50) in genotypically wild-type (gWT-S, P &lt; 0.001); isoniazid-gNWT-R &gt;4.0 (IQR 2.0–4.0) compared with 0.25 (IQR 0.12–1.00) among gWT-S (P = 0.001); ethionamide-gNWT-R 15.0 (IQR 10.0–20.0) compared with 2.50 (IQR; 2.50–5.00) among gWT-S (P &lt; 0.001). WGS correctly predicted resistance in 95% (36/38) and 100% (38/38) of the rifampicin-resistant isolates with ECOFFs &gt;0.5 and &gt;0.125 mg/L, respectively. No known resistance-conferring mutations were present in genes associated with resistance to fluoroquinolones, aminoglycosides, capreomycin, bedaquiline, delamanid, linezolid, clofazimine, cycloserine, or p-amino salicylic acid.

Conclusions
WGS-based drug resistance prediction worked well to rule-in phenotypic drug resistance and the absence of second-line drug resistance-mediating mutations has the potential to guide the design of RR/MDR-TB regimens in the future.
Therapeutic drug monitoring of cefepime in a non-critically ill population: retrospective assessment and potential role for model-based dosing
Authors: Suttels Véronique , André Pascal , Thoma Yann , Veuve François , Decosterd Laurent , Guery Benoît , Buclin Thierry 
Published: April 2022

Abstract

Objectives
To describe the therapeutic drug monitoring (TDM) of cefepime in non-critically ill adults and compare four different ways of dosing: conventional table-based; empirically adjusted following TDM; individualized based on a population pharmacokinetic (PopPK) model without TDM; and TDM-adjusted with a Bayesian approach integrating TDM and PopPK.

Methods
We conducted a retrospective study in a tertiary centre to examine the current practice of TDM and to evaluate the potential for improvement by PopPK-based software individualization. The prediction of trough concentrations and the total daily doses (TDD) prescribed according to each approach were compared by calculating the mean logarithmic bias and the root mean squared error, complemented by linear regression and variance analysis.

Results
Among 168 trough concentrations in 119 patients (median: 12 mg/L), 38.6% of measurements exceeded 15 mg/L, the reported threshold for neurotoxicity. Nine patients developed neurotoxicity. The prediction performance of PopPK alone for trough concentrations was moderate, but clearly improved after integration of TDM. Accordingly, TDD were significantly lower for a priori PopPK-based dosage (mean: 2907 mg/24 h) compared with actual table-based dosage (4625 mg/24 h, P &lt; 0.001). They were also lower for a posteriori dosage based on PopPK and TDM (3377 mg/24 h) compared with actual dosage after empirical TDM (4233 mg/24 h, P &lt; 0.001), as model-based adjustment privileged more frequent administrations.

Conclusions
Our observations support routine TDM of cefepime to prevent overdosing and subsequent toxicity in the non-critically ill. Software-based individualization seems promising to optimize the benefits of TDM, but has little potential to replace it.
Electronic health record developer market segmentation contributes to divide in physician interoperable exchange
Authors: Everson Jordan , Barker Wesley , Patel Vaishali 
Published: April 2022

Abstract

Objectives
To assess whether previously observed differences in interoperable exchange by physician practice size persisted in 2019 and identify the role of 3 factors shaping interoperable exchange among physicians in practices of varying sizes: Federal incentive programs designed to encourage health IT use, value-based care, and selection of electronic health record (EHR) developer.

Materials
Cross-sectional analysis of a 2019 survey of physicians. We used multivariable Poisson models to estimate the relative risk of interoperable exchange based on the size of the practice accounting for other characteristics and the mediating role of 3 factors.

Results
Seventeen percent of solo practice physicians integrated outside data relative to 51% of large practice physicians. This difference remained substantial in initial multivariable models including physician characteristics. When included in models, Federal incentive programs partially mediated the relationship between practice size and interoperable exchange status. In final models including EHR developer, developer was strongly associated with both exchange and integration while practice size was no longer an independent predictor. These trends persisted when comparing practices with 4 or fewer physicians to those with 5 or more.

Discussion
Public and private initiatives that increase the benefits of interoperable exchange may encourage small practices to pursue it. Technical and policy changes that reduce the costs and complexity of supporting exchange could make it easier for small developers to advance their capabilities to support small practices.

Conclusion
Addressing the gap between small and large practices will take a 2-pronged approach that targets both small EHR developers and small practices.
Supervised segmentation with domain adaptation for small sampled orbital CT images
Authors: Suh Sungho , Cheon Sojeong , Choi Wonseo , Chung Yeon Woong , Cho Won-Kyung , Paik Ji-Sun , Kim Sung Eun , Chang Dong-Jin , Lee Yong Oh 
Published: April 2022

Abstract
Deep neural networks have been widely used for medical image analysis. However, the lack of access to a large-scale annotated dataset poses a great challenge, especially in the case of rare diseases or new domains for the research society. Transfer of pre-trained features from the relatively large dataset is a considerable solution. In this paper, we have explored supervised segmentation using domain adaptation for optic nerve and orbital tumour, when only small sampled CT images are given. Even the lung image database consortium image collection (LIDC-IDRI) is a cross-domain to orbital CT, but the proposed domain adaptation method improved the performance of attention U-Net for the segmentation in public optic nerve dataset and our clinical orbital tumour dataset by 3.7% and 13.7% in the Dice score, respectively. The code and dataset are available at https://github.com/cmcbigdata.
Review of applications and user perceptions of smart home technology for health and environmental monitoring
Authors: Rhee Jee Heon , Ma Jae Hoon , Seo JoonOh , Cha Seung Hyun 
Published: April 2022

AbstractIn recent decades, smart home technology has advanced, improving the well-being and quality of life of its users. Thus, its applications have expanded, particularly in health and environmental monitoring. Numerous devices have been developed to accommodate user requirements of monitoring; however, the adoption of monitoring devices is closely related to user perception. User perception can be considered from different perspectives. One method of understanding different user perceptions is comparing wearable and nonwearable devices, owing to the differences in their obtrusiveness. The aim of this study was to systematically review the applications and user perceptions of health and environmental monitoring devices, emphasizing on the wearable and nonwearable distinction. We conducted a focused search of articles related to smart home technology and its user perceptions based on its applications. The inclusion criteria were original and peer-reviewed articles centered on health and environmental monitoring devices. We identified and analysed 159 of the 4476 relevant articles and divided the articles into two categories. The first category comprised health and environmental monitoring and their applications by the type of device. The second category comprised user perceptions of monitoring devices. The devices were grouped into wearable and nonwearable devices for our analysis. We identified user perceptions based on usefulness, ease of use, and privacy. Because wearable and nonwearable devices complement their limitations, we recommend their integration for improving user perception.
Weight distribution algorithm for global ship analysis in preliminary design stage
Authors: Lim Chaeog , Han Ik-seung , Park Byeong-cheol , Oh Sang-jin , Kim Gi-yong , Shin Sung-chul 
Published: April 2022

Abstract
Structural analysis, based on a global ship model, is vital for examining the structural strength and safety of a hull. In the “NASTRAN” global ship model, only the structural members and cargo tank of a ship are modeled and the outfit, electric system, and other tanks and liquid are omitted from the model. The additional weight of these omitted elements, however, constitutes part of the light weight of the ship and must be considered in conducting an accurate structural analysis of the ship. Generally, the weight of these omitted elements is calculated using the trim and stability information of the ship and is then added to the model. In such cases, the center of gravity of the global ship model, which now includes the weight of these omitted elements, must be adjusted to the target center of gravity required for the analysis. In this study, an algorithm was developed to satisfy the target center of gravity while distributing the weight of these omitted elements to the global ship model using Gaussian elimination. The algorithm was developed using C#, and its accuracy was verified by applying it to the global ship models.
L’Art Pour l’Art: Experiencing Art Reduces the Desire for Luxury Goods
Authors: Wang Yajin , Xu Alison Jing , Zhang Ying 
Published: April 2022

Abstract
When consumers shop in luxury boutiques, high-end shopping malls, and even online, they increasingly encounter luxury products alongside immersive art displays. Exploring this novel phenomenon with both field studies and lab experiments, the current research shows that experiencing art reduces consumer desire for luxury goods. Three boundary conditions have been identified. The effect does not materialize in contexts in which the work of art is not experienced as art per se, such as when the work of art appears as decoration on the product or packaging or is processed analytically rather than naturally, and when luxury goods are not seen as status goods. We propose that experiencing art induces a mental state of self-transcendence, which undermines consumers’ status-seeking motive and consequently decreases their desire for luxury goods. This research contributes to the literature on consumer esthetics and has important practical applications for luxury businesses.
Imitation and Piracy in Paisley Shawl Design, 1805–1870
Authors: Quaile Sheilagh 
Published: April 2022

Abstract
Facilitated by increased trade between Asia and Europe, handwoven shawls from the Kashmir region of the Indian subcontinent became desirable clothing for Europeans during the mid-eighteenth century. By the 1770s, European manufacturers had picked up on this trend, producing textiles that imitated Kashmiri shawls but sold at lower prices to meet a wider market. In this article, I investigate the imitation Kashmiri shawl industry of one of the most prominent European centers of shawl production—the town of Paisley, Scotland—to study the designing of its products between 1805 and 1870. I examine the training and sources used by Paisley’s ‘pattern drawers’—as the industry’s designers were then called—to answer the question: How much did Paisley’s pattern drawers rely on the patterns of their competitors—European and Asian—to produce their own work? And did all Paisley pattern drawers pirate others’ work? The answer will provide insight into the intertwined nature of imitation and innovation, and moral assessments of copying from European versus Asian products.
Giorgio de Chirico’s artful deception: The story of Nathan Cummings’s ‘true-fakes’ scandal
Authors: Farmer Sophia Maxine 
Published: April 2022

Abstract
In 1953 Nathan Cummings purchased six paintings from Giorgio de Chirico. Accompanying these works was a letter from the artist indicating the dates and titles of the paintings. Cummings nevertheless came to question the authenticity of the dates of these works. While it may seem odd for an artist to be challenged on the dating of his own work, in de Chirico’s case the doubts raised by Cummings were not without precedent. From the 1920s, de Chirico, frustrated with the art market’s rejection of his later work, created copies or ‘verifalsi’, which played off the compositions and themes of his earlier style and bore dates from his Metaphysical period in the 1910s. There is little doubt that de Chirico backdated the paintings sold to Cummings. The correspondence between the artist, Cummings and James Thrall Soby, the leading authority on de Chirico’s works, reveals much about de Chirico’s reasoning and the treatment his later output received in the art market.
Rock value: Scientific and economic conditions for collecting minerals in the early nineteenth century
Authors: Strauß Angela 
Published: April 2022

Abstract
The physician Carl Wilhelm Nose (1753–1835) invested a substantial amount of time and money in exploring the rocks of the Siebengebirge, a mountain range in western Germany from the 1780s onwards. Although virtually unknown today, during his lifetime Nose earned a reputation as a leading mineralogical expert in German-speaking countries. He used his private rock collections as the basis for his research, and hoped that his findings would support his position in one of the fundamental scientific debates of the time – the neptunism–volcanism controversy, which concerns the question of the origin of the earth. At the same time, Nose sought to gain recognition for his rock-collecting work. He gave free samples to institutions and individuals, and donated specimens to various institutions. In 1814 he gifted his private collection of rocks to the Royal Mineral Cabinet in Berlin, a precursor of today’s Museum für Naturkunde there. Nose’s rocks provide deep insights into the mineral-collecting and donation practices of the early nineteenth century, the era in which modern scientific museums emerged. In addition, their collection history shows how the transformation of natural objects into museum objects was linked to the scientific, monetary and economic values attached to them. This paper argues that these natural objects embody epistemic and economic values combined.
International Efforts Against Impunity for the Use of Chemical Weapons in Syria
Authors: Aloklah Wissam Aldien 
Published: April 2022

Abstract
This article examines international developments in the investigation of incidents involving the use of chemical weapons (CWs) in Syria between 2012 and 2021. Specifically, it analyses the measures adopted by the Organization for the Prohibition of Chemical Weapons (OPCW) in cooperation with the United Nations, and the progress in eliminating the Syrian chemical weapons programme. The article further addresses the international community’s responses to the use of CWs in Syria from the perspective of international law, and its inability to hold those responsible accountable and to offer redress the victims. Such inability is illustrated by the somewhat weak action following two reports of the Investigation and Identification Team of the OPCW, which clearly indicated that the authorities of the Syrian Arab Republic are behind a number of CW attacks in Syria. The article argues that the lack of international justice, despite clear evidence of blatant violations, is rooted in the fundamental differences between major powers within the Security Council, as well as in the existing gaps in the law.
Current trends in chemotherapy for advanced ovarian cancer
Authors: Takahashi Nobutaka , Takekuma Munetaka 
Published: April 2022

Abstract
Chemotherapy for advanced ovarian cancer has progressed over the past several decades with the introduction of cytotoxic agents. Various methods, including single agents, combination therapy and changes in the method of administration, have been validated in many clinical trials and have been combined in an attempt to improve the prognosis of advanced ovarian cancer. In recent years, molecular-targeted agents have been added to cytotoxic agents as a treatment option for maintenance therapy; however, their efficacy has been limited, and further development of treatment options is expected. The advent of poly(ADP-ribose) polymerase inhibitors has considerably improved prognosis and has affected treatment strategies for advanced ovarian cancer over the past few years. With the addition of the recently introduced immune checkpoint inhibitors, future treatment strategies for advanced ovarian cancer may become more complex. In this review, we introduce the latest advances in chemotherapy for advanced ovarian cancer and discuss future perspectives.