bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Faster R-CNN and YOLOv5 for Overlapping Objects Recognition
Authors: Yusro Muhamad Munawar , Ali Rozniza , Hitam Muhammad Suzuri 
Published: November 2022

يعد تصنيف الجسم المتداخل أحد التحديات الرئيسية التي يواجهها الباحثون الذين يعملون في اكتشاف الأشياء والتعرف عليها. معظم الخوارزميات المتاحة التي تم تطويرها قادرة فقط على تصنيف أو التعرف على الأشياء التي تكون إما منفصلة بشكل فردي عن بعضها البعض أوجسم واحد في مشهد (مشاهد) ، ولكن لا تتداخل مع اجسام أدوات المطبخ. في هذا المشروع ، تم اقتراح خوارزميات Faster R-CNN و YOLOv5 لاكتشاف وتصنيف جسم متداخل في منطقة المطبخ. تم تطبيق YOLOv5 و Faster R-CNN على االاجسام المتداخلة حيث من المتوقع أن يتمكن المرشح أو النواة من فصل االجسم المتداخل في الطبقة المخصصة لتطبيق النماذج. تم استخدام قاعدة بيانات الصور المعيارية لأدوات المطبخ وأدوات المطبخ المتداخلة من الإنترنتااجسام مرجعية أساسية. تم تعيين مجموعات التقييم والتدريب / التحقق عند 20٪ و 80٪ على التوالي. قام هذا المشروع بتقييم أداء هذه التقنيات وتحليل نقاط قوتها وسرعاتها بناءً على الدقة والدقة ودرجةF1. خلصت نتائج التحليل في هذا المشروع إلى أن YOLOv5 ينتج مربعات إحاطة دقيقة بينما يكتشف Faster R-CNN المزيد من االاجسام. في بيئة اختبار مماثلة ، يُظهر YOLOv5 أداءً أفضل من خوارزمية R-CNN الأسرع. بعد التشغيل في نفس البيئة، حصل هذا المشروع على دقة 0.8912 (89.12٪) لـ YOLOv5 و 0.8392 (83.92٪) لـ Faster R-CNN ، بينما كانت قيمة الخسارة 0.1852 لـ YOLOv5 و 0.2166 لأسرع R-CNN. تعد المقارنة بين هاتين الطريقتين هي الأكثر حداثة ولم يتم تطبيقها مطلقًا في الكائنات المتداخلة وخاصة أدوات المطبخ.
Mn(II),Fe(III),Co(II)and Rh(III) complexes with azo ligand: Synthesis, characterization, thermal analysis and bioactivity
Authors: Reda Shaima Mohammed , Al-Hamdani Abbas Ali Salih 
Published: November 2022

حضرت سلسلة لمعقدات ايونات المعادن من الليكاند الجديد 4- امينو (5- مثيل-ايكسازول-3- ايل)-بنزينسلفون اميد المشتقة من سلفاميثوكسازول و3- امينو فينول ، المعقدات احادية النوى لكل من المنغنيز الثنائي والحديد الثلاثي والكوبلت الثنائي والروديوم الثلاثيمن تفاعل الليكاند مع املاح ايونات المعادن. المركبات شخصت بأطياف تحت الحمراء وفوق البنفسجية –المرئية و الكتلة و الرنين النووي المغناطيسي للبروتون والكاربون ومنحنى التحلل الحراري الوزني والمسعر الحراري التفاضلي والحساسية المغناطيسية والتحليل الدقيق للعناصر ونسبة الايون ومحتوى الكلور والتوصيلية المولارية وفقا للدراسات التحليلية اعطت المعقدات شكل ثماني السطوح(1:2) ( ليكاند : فلز ) وبينت الدراسات الحرارية ان المعقدات تحوي جزيئات متناسقة.
Synthesis and characterization of magnetic bifunctional nano-catalyst for the production of biodiesel from Madhuca indica oil
Authors: Ramasamy Sivakumar Sivakumar Vadakku Mannam , Booramurthy Vijaya Kumar , Pandian Sivakumar , Albaqami Munirah Dukhi , Alotabi Reham Ghazi 
Published: November 2022

Abstract
The reusable magnetic bifunctional nano-catalyst (Fe3O4.Cs2O) was synthesized by co-precipitation and incipient wetness impregnation method. It was utilized for the transesterification of Madhuca indica (M. indica) oil with methanol. The prepared catalyst, cesium oxide doped on the nano-magnetite core was characterized by using Field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). Further, the activity of the catalyst was investigated by subjecting it to biodiesel reaction. To maximize the biodiesel conversion, studies were carried out by varying the parameters like catalyst concentration, methanol-to-oil molar ratio, reaction temperature and reaction time. The yield of 97.4 wt% was obtained at the holding conditions: 18:1 methanol-to-oil ratio, 7 wt% catalyst loading, 65°C reaction temperature and 300 min of reaction time. Moreover, the catalyst recyclability was also studied and found that it can be recycled up to 12 cycles with a conversion of above 90%. The biodiesel’s fuel properties were analyzed and compared with the ASTM standard.
Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer
Authors: Takada Koji , Kashiwagi Shinichiro , Iimori Nozomi , Kouhashi Rika , Yabumoto Akimichi , Goto Wataru , Asano Yuka , Tauchi Yukie , Morisaki Tamami , Ogisawa Kana , Shibutani Masatsune , Tanaka Hiroaki , Maeda Kiyoshi 
Published: November 2022

Abstract
Purpose: A meta-analysis examining the relationship between statin use and breast cancer reported that the inhibitory effect of statins on breast cancer may be more pronounced in early-stage cases. In this study, we aimed to investigate the effects of hyperlipidemia treatment at the time of breast cancer diagnosis and to examine its correlation with metastasis to axillary lymph nodes among patients with so-called cT1 breast cancer whose primary lesion was 2 cm or less and was pathologically evaluated by sentinel lymph node biopsy or axillary lymph node dissection. We also investigated the effects of hyperlipidemic drugs on the prognosis of patients with early-stage breast cancer.
Methods: After excluding cases that did not meet the criteria, we analyzed data from 719 patients who were diagnosed with breast cancer, with a primary lesion of 2 cm or less identified by preoperative imaging, and who underwent surgery without preoperative chemotherapy.
Results: Regarding hyperlipidemia drugs, no correlation was found between statin use and lymph node metastasis (p = 0.226), although a correlation was found between lipophilic statin use and lymph node metastasis (p = 0.042). Also, the disease-free survival periods were prolonged following treatment of hyperlipidemia (p = 0.047, hazard ratio: 0.399) and statin administration (p = 0.028, hazard ratio: 0.328).
Conclusion: In cT1 breast cancer, the results suggest that oral statin therapy may contribute to favorable outcomes.
Acromioclavicular joint reconstruction: An analysis of the readability and quality of online patient information
Authors: O’Dwyer Liam , Murphy Ben , O’Farrell Dermot 
Published: November 2022

Abstract

Background: Currently, patients use the internet for health information relating to surgery. The aim of this study is to assess the readability and quality of online health information relating to acromioclavicular joint reconstruction. We hypothesize that the information will be of poor quality and be too difficult to read for the average patient.
Methods: The top 50 results from Google, Bing, and yahoo (MeSH “acromioclavicular joint reconstruction”, “ac joint reconstruction”) were used for analysis. Readability was assessed using 3 scores (Gunning FOG (GF), Flesch Kincaid Grade (FKG), and Flesch Reading Ease (FRE), these scores were generated using an online calculator (www.readable.com). Quality was assessed using a HONcode google toolbar extension and JAMA benchmark criteria.
Results: 116 URLs were subject to analysis. The mean GF was 12.11 ± 2.88. The mean FKG was 10.59 ± 2.15. The mean FRE was 38.86 ± 13.27. FRE score found no website pitched at 6th grade level, and only 4 (3.4%) and 2 (1.7%) of the websites were pitched at this level according to the GF and FKG scores respectively. The mean JAMA score was 1.91 ± 1.51. Only 10 websites had HONcode certification.
Conclusion: The quality of online patient information pertaining to acromioclavicular joint reconstruction is of poor quality and is too difficult to read. Providing high quality online information, that is easy to read for the average patient, will lead to better patient contribution to the shared-decision making process, and thus better patient outcomes.
Changes in fish species diversity, size structure and distribution in the trawlable demersal zones of Lake Malawi, Malawi
Authors: M'balaka Mwamad Salim , Kaunda Emmanuel , Kanyerere Geoffrey Z. , Jamu Daniel , Msukwa Amulike 
Published: November 2022

Abstract
A study was conducted to assess temporal and spatial changes in the trawlable demersal zones of Lake Malawi. Data from surveys conducted in 1998 and 2020 targeting 120 stations covering a surface area of 9,647.97km2 was used. Trawling speed of Research Vessel Ndunduma was restricted to 4.6km/hr. Length frequency distribution was modelled with the probability density function for determining the likelihoods in the gamma distribution. Parameters for modal length and logistic modelling were guessed and Solver in Microsoft Excel 2021 was used to generate the best of fit values through iteration with GRG Nonlinear approach. The study determined fish diversity using the Shannon and Weiner relationship. The recent survey recorded fewer fish species (149) against 158 sampled in the previous survey. The overall catch rates in 2020 and 1998 ranged from 3.8kg/0.5hr to 2003.8kg/0.5hr and 28.7 kg/0.5 to 1,884.3 kg/0.5hr, respectively. Overall fish density in the 2020 and 1998 surveys was calculated at 11.7tons/km2 and 7.5tons/km2, respectively representing a 35.6% drop. The study has revealed temporal and spatial shifts in the fish stock composition, distribution and abundance which necessitates urgent management interventions to prevent further fisheries resource losses. Efforts to regulate mesh sizes of the cod-ends of trawlers are encouraged just like the initiative of introducing a closed season for the commercial operators.
Structural basis of sequence-specific cytosine deamination by double-stranded DNA deaminase toxin DddA
Authors: Aihara Hideki , Yin Lulu , Shi Ke 
Published: November 2022

Abstract
An interbacterial deaminase toxin DddA catalyzes cytosine-to-uracil conversion in double-stranded (ds) DNA and enables CRISPR-free mitochondrial base editing, but the molecular mechanisms underlying its unique substrate selectivity remained unknown. Here we report crystal structures of DddA bound to a dsDNA substrate containing the 5'-TC target motif. The structures show that DddA binds to the minor groove of a sharply bent dsDNA and engages the target cytosine extruded from the double-helix. DddA Phe1375 intercalates in dsDNA and displaces the 5' (–1) thymine, which in turn replaces the target (0) cytosine and forms a non-canonical T-G base-pair with the juxtaposed guanine. This “domino effect” mechanism allows DddA to locate the target cytosine without flipping it into the active site. Biochemical experiments show that DNA base-mismatches enhance DddA deaminase activity and relax its sequence selectivity. Based on the structural information, we further identified DddA mutants that exhibit attenuated activity or altered substrate preference. Our studies may help design novel tools useful in genome editing or other applications.
Spontaneous, persistent T-cell dependent IFN-γ release in patients who progress to Long COVID
Authors: Krishna Benjamin , Lim Eleanor , Mactavous Lenette , Jackson Sarah , Team NIHR BioResource Team NIHR BioResource , Lyons Paul , Doffinger Rainer , Bradley John , Smith Kenneth , Sinclair John , Matheson Nicholas , Lehner Paul , Sithole Nyaradzai , Wills Mark 
Published: November 2022

Abstract
After acute infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), a significant proportion (0.2 – 30%) of patients experience persistent symptoms beyond 12 weeks, termed Long COVID. Understanding the mechanisms which cause this debilitating disease and identifying biomarkers for diagnostic, therapeutic and monitoring purposes is urgently required. Persistently high levels of IFN-γ were detected from peripheral blood mononuclear cells (PBMCs) of Long COVID patients using highly sensitive FluoroSpot assays. This IFN-γ release was seen in the absence of ex vivo peptide stimulation and remains persistently elevated in Long Covid patients, unlike the resolution seen in patients recovering from acute SARS-CoV-2 infection. IFN-γ release was CD8+ T cell mediated and dependent on MHC-I antigen presentation by CD14+ cells. After vaccination, a significant decrease in IFN-γ correlated with resolution of some Long COVID symptoms. Our study highlights a key mechanism underlying Long COVID, enabling the search for biomarkers and therapeutics in patients with Long COVID.
Effects of pipelle endometrial biopsy on pretreatment tumor sampling for advanced ovarian, fallopian tube, and primary peritoneal cancers
Authors: Tamura Ryo , Kitani Yohei , Takahashi Kotaro , Yamaguchi Masayuki , Nishikawa Nobumichi , Kawasaki Takashi , Kikuchi Akira 
Published: November 2022

Abstract
Pipelle endometrial biopsy has been widely performed as an effective and minimally invasive test for endometrial diseases. However, the effectiveness of pretreatment pipelle endometrial biopsy in the ovarian, fallopian tube, and peritoneal cancers remains unexplored. We performed pretreatment pipelle endometrial biopsy for 90 patients with ovarian, fallopian tube, and primary peritoneal cancers from January 2014 to November 2021. We retrospectively analyzed the association between the results of pipelle endometrial biopsy and clinicopathological data. 25/61 (41.0%) cases with clinical stage II or higher were diagnosed with pipelle endometrial biopsy-positive (Pipelle-positive) and Pipelle-positive was not observed in 29 cases with clinical stage I. Pipelle-positive had significantly more high-grade serous carcinomas, positive peritoneal cytology, positive endometrial cytology, and positive cervical cytology than pipelle endometrial biopsy-negative cases. In 23 Pippele-positive, we confirmed surgical pathology, and 17/23 (74.0%) had a completely same diagnosis with pipelle endometrial biopsy. Conversely, 6/23 (26.0%) showed a minor diagnostic discrepancy between pipelle endometrial biopsy and surgical pathology. Companion diagnostic tests were performed using pipelle endometrial biopsy samples in four primarily inoperable patients and all tests were evaluable. Pipelle endometrial biopsy may allow for prompt histological diagnosis and initiation of chemotherapy while collecting tumor tissue for genetic testing in some advanced cases.
Does capecitabine maintenance therapy versus active monitoring confer a survival benefit after first-line treatment of metastatic colorectal cancer? A meta-analysis of randomized controlled trials
Authors: Fan Ling , Chen Bo , Ying Jie , Wu Tao , Yue Yumin , Chen Jian , Zheng Bobo 
Published: November 2022

Abstract
Background
The maintenance treatment of metastatic colorectal cancer (mCRC) after first-line treatment is still controversial. Meta analysis was used to analyze whether there was survival benefit after first-line treatment of mCRC from the effectiveness and safety of capecitabine maintenance treatment.
Methods
In April, 2022, the following biomedical electronic databases were searched: PubMed, EMBASE, Google Scholar and Cochrane Library, including capecitabine maintenance therapy versus active monitoring randomized controlled trials (RCTs) and clinical trials (CT) of mCRC patients after first-line treatment. The primary outcome was progression free survival (PFS) of capecitabine maintenance therapy, and secondary outcomes included overall survival (OS), toxicity, and BRAF and RAS gene mutation status. Extract the hazard ratio (HR) of 95% confidence interval (CI) or HR data that can calculate 95% confidence interval (CI). All data were analyzed by Revman5.4 software.
Results
Five eligible studies included 1672 patients. Meta analysis showed that capecitabine maintenance therapy had more significant benefits for PFS than active monitoring PFS (HR 0.59; 95%CI: 0.52–0.66; P < 0.00001); In addition, capecitabine maintenance therapy was also beneficial to OS (HR 0.85; 95% CI: 0.76–0.95; p = 0.003). Subgroup analysis showed that BRAF/RAS wild-type patients were more likely to benefit from capecitabine maintenance, based on the significant interaction between BRAF/RAS status (P = 0.002). The most common adverse reaction was hand-foot skin reaction to capecitabine maintenance therapy compared with active monitoring (2.3% vs 0.4%; OR 5.53, 95%CI: 1.42–21.58, I2 = 0%, P = 0.01) was slightly increased.
Conclusion
This meta-analysis suggests that capecitabine was beneficial in PFS and OS compared with active monitoring. Adverse reactions are common but acceptable. Subgroup analysis showed that the differential effect of capecitabine maintenance treatment was beneficial to BARF/RAS wild-type patients. In specific cases, capecitabine monotherapy maintenance therapy can be considered, such as cumulative toxicity to fluoropyrimidine or patient rejection, especially for BRAF/RAS wild-type patients.
Universal and high efficient extraction of lithium for LIB recycling using mechanochemistry.
Authors: Dolotko Oleksandr , Gehrke Niclas , Malliaridou Triantafillia , Hunzinger Bettina , Knapp Michael , Ehrenberg Helmut 
Published: November 2022

Abstract
The increasing lithium-ion battery production calls for profitable and ecologically benign technologies for recycling and recovering critical components, such as Li. Unfortunately, all currently used industrial ways of recycling are always associated with large energy consumption and utilization of corrosive reagents, which creates a risk to the environment. Herein we report a high efficient mechanochemically induced acid-free process for recycling Li from cathode materials of different and mainly used chemistries such as LiCoO2, LiMn2O4, Li(CoNiMn)O2, and LiFePO4. The introduced technology uses Al as a reducing agent in the mechanochemical reaction. Two different processes have been developed to regenerate lithium from cathode materials and to transform it to the pure Li2CO3. The mechanisms of mechanochemical transformation, aqueous leaching, and the lithium purification process were investigated. The presented technology achieves a recovery rate for Li of up to 70% without applying any corrosive leachates or utilizing high temperatures. The key innovation is that the regeneration of lithium was successfully performed for all relevant cathode chemistries, including their mixture. As a result, the engineered process can be declared universal and therefore be applied for lithium recovery from spent LIBs without the sorting step, thus improving the economic benefit of recycling.
Systematic Analysis of GT1 Family Genes and Their Regulation in Anthocyanin Metabolism in Red Maple
Authors: Xu Hao , Zhu Qing , Lu Xiaoyu 
Published: November 2022

Abstract
Glycosyltransferases (GTs) have a crucial role in the glycosylation of secondary metabolites, detoxification of endogenous or exogenous substances, body defense, and hormone regulation in plants. The GT1 family has the largest number of characterized enzymes in 111 GT families that are known for their excellent glycosylation capacities toward numerous valued small molecules. The colorful foliage of red maple is a vital agronomic trait, and studies have confirmed that massive anthocyanin accumulation led to the redness of leaves. In red maple, glycosylation is the essential step of anthocyanin biosynthesis and the prerequisite of further modifications, which usually enhances stability. Here, a genome-wide characterization analysis of the GT1 family in red maple was performed. A total of 560 GT genes were identified in the red maple genome; among them, 122 members belonged to the GT1 family. All these members were unevenly distributed across 19 chromosomes, with most located in the chloroplast. These GT1 genes had 1–16 exons. Most 122 GT1 proteins in red maple contained GT-GTB-type domain and GT1-Gtf-like domain. In total, 18 GT1 proteins might have played pivotal evolutionary roles in red maple. The network analysis revealed that the regulatory effect of GT1 family genes on anthocyanin in red maple leaves could be divided into direct and indirect regulation. The study results not only clarified the roles of the GT1 family in red maple but also laid a cornerstone for further functional analysis of this gene family in Acer plants.
SIRT6 is a key regulator of mitochondrial function in the brain
Authors: Smirnov Dmitrii , Eremenko Ekaterina , Stein Daniel , Kaluski Shai , Jasinska Weronika , Consentino Claudia , Martinez-Pastor Barbara , Brotman Yariv , Mostoslavsky Raul , Khrameeva Ekaterina , Toiber Debra 
Published: November 2022

Abstract
SIRT6 is implicated in DNA repair, telomere maintenance, glucose and lipid metabolism and, importantly, it has critical roles in the brain ranging from its development to neurodegeneration. In this work, we combined transcriptomics and metabolomics approaches to characterize the functions of SIRT6 in mice brains. Our analysis revealed that SIRT6 is a critical regulator of mitochondrial activity in the brain. In its absence, there is a mitochondrial deficiency with a global downregulation of mitochondria-related genes and pronounced changes in metabolites content. We predict that SIRT6 can affect mitochondrial functions through its interaction with the transcription factor YY1 that, together, regulate mitochondrial gene expression. Moreover, SIRT6 target genes include SIRT3 and SIRT4, which are significantly downregulated in SIRT6-deficient brains. Our results demonstrate that the lack of SIRT6 leads to decreased mitochondrial gene expression and metabolomic changes of TCA cycle byproducts, including increased ROS production, reduced mitochondrial number, and impaired membrane potential that can be partially rescued by restoring SIRT3 and 4 levels. Importantly, the changes observed in SIRT6 deficient brains are observed in brains of aging people, but the overlapping is greater in patients with Alzheimer's, Parkinson's, Huntington's, and Amyotrophic lateral sclerosis disease. Overall, our results suggest that reduced levels of SIRT6 in the aging brain and neurodegeneration could initiate mitochondrial dysfunction by altering gene expression, ROS production and mitochondrial decay.
NetBID2 provides comprehensive hidden driver analysis
Authors: Yu Jiyang , Dong Xinran , Ding Liang , Thrasher Andrew , Wang Xinge , Liu Jingjing , Pan Qingfei , Rash Jordan , Dhungana Yogesh , Yang Xu , Risch Isabel , Li Yuxin , Peng Junmin , Rusch Michael , McLeod Clay , Chi Hongbo , Zhang Jinghui 
Published: November 2022

Abstract
We present a comprehensive and versatile toolkit, NetBID2, for integrating multi-omics data and exposing hidden drivers that are not genetically altered or differentially expressed at the RNA/protein level by reverse-engineering context-specific interactomes and inferring protein activity. We deploy NetBID2 Viewer, Runner, and Cloud apps with 145 context-specific gene regulatory and signalling networks across normal tissues and paediatric and adult cancers to facilitate real-time interactive visualization, analysis, end-to-end use, and sharing.