bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Bike-courier as an Energy Efficiency Instrument at the University of Guadalajara (Pilot Study)
Authors: Ramírez-Sánchez Hermes Ulises , Hernández-Salazar José Antonio 
Published: May 2022

Introducción: The struggle and concern for climate change, the optimization of natural resources, the well-being of future generations, has permeated the public institutions of our country. In particular, the University of Guadalajara, a public body for higher education, has launched projects aimed at this direction. The year 2020 at the University of Guadalajara was declared as the "Year of the Energy Transition at the University of Guadalajara”. Likewise, the Program of Austerity, Rationality and Efficiency of Institutional Resources of the University of Guadalajara was launched, implemented and applicable to the entire University Network and of a mandatory nature, to rationalize institutional spending by establishing: A decrease in energy resources through rational, responsible and sustainable use, proposing "to reduce spending on fossil fuels and lubricants by 40%, optimizing its consumption" together with a gradual transition of the vehicle fleet, "The conversion of the vehicle fleet to the electric and hybrid type will be strengthened".
Materials and Methods: Considering the above and associated with the opportunity to take as a pilot test the Transport Office of the Rectory General, it was established to replace by bike-courier the delivery of documents and light parcels in dependencies with distances less than 5 km of radius of the administrative building of the University of Guadalajara that is currently carried out using a car, seeking energy reduction, without losing efficiency in deliveries and contributing to meet the institutional goals of resource optimization and environmental contribution. The messaging and departure requests of the agency's operational vehicles were tracked during the year 2019.
Results and Discussion: Accounting for the annual record, only the requested trips with distances less than 5 km are those considered to be made by bicycle because they are requests for delivery of documentation, being 40.88% of these those susceptible to be delivered by bicycle, representing 2,237.54 kilometers and 187.05 liters of fuel saved, contributing to the fulfillment of the institutional goal of reducing fossil fuels by 40%. It was also evidenced that the efficiency of the bike-courier, in most cases is higher than the automotive, under the criteria and variables analyzed, using the Data Enveloping Analysis (DEA).
Evolution of neurologic symptoms in non‐hospitalized COVID‐19 “long haulers”
Authors: Ali Sareen T. , Kang Anthony K. , Patel Tulsi R. , Clark Jeffrey R. , Perez‐Giraldo Gina S. , Orban Zachary S. , Lim Patrick H. , Jimenez Millenia , Graham Edith L. , Batra Ayush , Liotta Eric M. , Koralnik Igor J. 
Published: May 2022

AbstractObjectiveWe characterized the evolution of neurologic symptoms and self‐perceived recovery of non‐hospitalized COVID‐19 “long haulers” 6–9 months after their initial Neuro‐COVID‐19 clinic evaluation.MethodsIn this follow‐up study on the first 100 patients, 50 SARS‐CoV‐2 laboratory‐positive (SARS‐CoV‐2+), and 50 laboratory‐negative (SARS‐CoV‐2−), evaluated at our Neuro‐COVID‐19 clinic between May and November 2020, patients completed phone questionnaires on their neurologic symptoms, subjective impression of recovery and quality of life.ResultsOf 52 patients who completed the study (27 SARS‐CoV‐2+, 25 SARS‐CoV‐2−) a median 14.8 (range 11–18) months after symptom onset, mean age was 42.8 years, 73% were female, and 77% were vaccinated for SARS‐CoV‐2. Overall, there was no significant change in the frequency of most neurologic symptoms between first and follow‐up evaluations, including “brain fog” (81 vs. 71%), numbness/tingling (69 vs. 65%), headache (67 vs. 54%), dizziness (50 vs. 54%), blurred vision (34 vs. 44%), tinnitus (33 vs. 42%), and fatigue (87 vs. 81%). However, dysgeusia and anosmia decreased overall (63 vs. 27%, 58 vs. 21%, both p < 0.001). Conversely, heart rate and blood pressure variation (35 vs. 56%, p = 0.01) and gastrointestinal symptoms (27 vs. 48%, p = 0.04) increased at follow‐up. Patients reported improvements in their recovery, cognitive function, and fatigue, but quality of life measures remained lower than the US normative population (p < 0.001). SARS‐CoV‐2 vaccination did not have a positive or detrimental impact on cognitive function or fatigue.InterpretationNon‐hospitalized COVID‐19 “long haulers” continue to experience neurologic symptoms, fatigue, and compromised quality of life 14.8 months after initial infection.
A learning framework of modified deep recurrent neural network for classification and recognition of voice mood
Authors: Agarwal Gaurav , Om Hari , Gupta Sachi 
Published: May 2022

SUMMARYRecognition of human emotions is a basic requirement in many real‐time applications. Detection of exact emotions through voice provides relevant information for various purposes. Several computational methods have been employed for the clear analysis of human emotions. Most of the previous approaches face complexities due to certain drawbacks like degraded signal quality, a requirement of high storage space, increased computational complexity, and deteriorated outcomes of classification accuracy. The proposed work was implemented to gather the accurate classification result of embedded emotions and minimize the computational complexities of MDDTRNN (modified deep duck and traveler recurrent neural network). The proposed work includes four steps: preprocessing, feature extraction, feature selection, and classification. In feature extraction, the spectral and frequency features are extracted using the adopting boosted MFCC (Mel frequency cepstral coefficients) method to improve training speed. In feature selection, the best features are selected using an algorithm of AAVOA (adaptive African vulture optimization algorithm). To provide optimal emotion results, the classification step is undertaken by the MDDTRNN technique. The proposed work shows better classification outcomes of emotions when compared to the existing approaches by holding the accuracy of (95.86%), precision as (93.79%), specificity as (94.28%), sensitivity as (92.89%) and the error rate is attained to be 5.266 in terms of IEMOCAP dataset. The accuracy result (96.27%), precision (94.83%), specificity (93.16%), sensitivity (94%) and the error rate is achieved to be 4.982 in terms of the EMODB dataset.
Churn in the older adult SNAP population
Authors: Heflin Colleen , Hodges Leslie , Arteaga Irma , Ojinnaka Chinedum O. 
Published: May 2022

AbstractUsing administrative records from Missouri, we investigate the characteristics of Supplemental Nutrition Assistance Program (SNAP) participants aged 60 and older who experience administrative churn. Among these adults, one in four experienced administrative churn, and one in five experienced more than one spell of churn. Risk of churn, frequency, duration of churn spells, and the value of foregone SNAP benefits varied with individual, household, and geographic characteristics, and was more common among non‐Whites, members of larger households, and those living in urban areas. Our findings suggest that a significant portion of older adults experience gaps in SNAP benefit receipt.
Current clinical practice for familial adenomatous polyposis in Japan: A nationwide multicenter study
Authors: Matsubara Takaaki , Beppu Naohito , Ikeda Masataka , Ishida Hideyuki , Takeuchi Yoji , Nagasaki Toshiya , Takao Akinari , Sasaki Kazuhito , Akagi Kiwamu , Sudo Tomoya , Ueno Hideki , Yamaguchi Tatsuro , Tomita Naohiro , Ajioka Yoichi 
Published: May 2022

AbstractIntroductionIn Japanese patients with familial adenomatous polyposis (FAP), colectomy tends to be postponed or avoided.AimThis study aimed to clarify the current clinical practice from a Japanese multicenter cohort study database.MethodsWe analyzed the records of 250 patients with non‐dense FAP who did not require colorectal cancer removal. The clinical outcomes were compared between patients who received colectomy (n = 142) (Group A) and those who did not receive colectomy (n = 108) (Group B).ResultsThe colectomy rate based on the age at the final follow‐up examination was 46%, 60%, 54%, 65%, at ≤29, 30–39, 40–49, and ≥ 50 years, respectively (P = .11). The development of colorectal cancer did not differ between Groups A and B (25% vs 22% P = .67); however, colorectal cancer was diagnosed at the Tis stage in 88% of the patients with colorectal cancer in Group B, and 34% of the patients with colorectal cancer in Group A (P < .01). Regarding survival, all patients in Group B were alive at the final follow‐up examination. In contrast, six patients in Group A died, including three patients with desmoid tumors and one with colon cancer.ConclusionOver one‐third of patients with non‐dense FAP (polyps ≤ 1000) in Japan did not receive colectomy at >30 years of age, and patients who managed without colectomy showed acceptable survival with the early diagnosis of colorectal cancer, and a very low incidence of desmoid tumor development, indicating that this approach represents a potential option for the management of selected non‐dense FAP patients.
Holding on or falling off: The attachment mechanism of epiphytic Anthurium obtusum changes with substrate roughness
Authors: Tay Jessica Y. L. , Kovalev Alexander , Zotz Gerhard , Einzmann Helena J. R. , Gorb Stanislav N. 
Published: May 2022

AbstractPremiseFor vascular epiphytes, secure attachment to their hosts is vital for survival. Yet studies detailing the adhesion mechanism of epiphytes to their substrate are scarce. Examination of the root hair–substrate interface is essential to understand the attachment mechanism of epiphytes to their substrate. This study also investigated how substrate microroughness relates to the root–substrate attachment strength and the underlying mechanism(s).MethodsSeeds of Anthurium obtusum were germinated, and seedlings were transferred onto substrates made of epoxy resin with different defined roughness. After 2 months of growth, roots that adhered to the resin tiles were subjected to anchorage tests, and root hair morphology at different roughness levels was analyzed using light and cryo scanning electron microscopy.ResultsThe highest maximum peeling force was recorded on the smooth surface (glass replica, 0 µm). Maximum peeling force was significantly higher on fine roughness (0, 0.3, 12 µm) than on coarse (162 µm). Root hair morphology varied according to the roughness of the substrate. On smoother surfaces, root hairs were flattened to achieve large surface contact with the substrate. Attachment was mainly by adhesion with the presence of a glue‐like substance. On coarser surfaces, root hairs were tubular and conformed to spaces between the asperities on the surface. Attachment was mainly via mechanical interlocking of root hairs and substrate.ConclusionsThis study demonstrates for the first time that the attachment mechanism of epiphytes varies depending on substrate microtopography, which is important for understanding epiphyte attachment on natural substrates varying in roughness.
A Photoswitchable Ligand Targeting the β1‐Adrenoceptor Enables Light‐Control of the Cardiac Rhythm**
Authors: Duran‐Corbera Anna , Faria Melissa , Ma Yuanyuan , Prats Eva , Dias André , Catena Juanlo , Martinez Karen L. , Raldua Demetrio , Llebaria Amadeu , Rovira Xavier 
Published: May 2022

AbstractCatecholamine‐triggered β‐adrenoceptor (β‐AR) signaling is essential for the correct functioning of the heart. Although both β1‐ and β2‐AR subtypes are expressed in cardiomyocytes, drugs selectively targeting β1‐AR have proven this receptor as the main target for the therapeutic effects of beta blockers in the heart. Here, we report a new strategy for the light‐control of β1‐AR activation by means of photoswitchable drugs with a high level of β1‐/β2‐AR selectivity. All reported molecules allow for an efficient real‐time optical control of receptor function in vitro. Moreover, using confocal microscopy we demonstrate that the binding of our best hit, pAzo‐2, can be reversibly photocontrolled. Strikingly, pAzo‐2 also enables a dynamic cardiac rhythm management on living zebrafish larvae using light, thus highlighting the therapeutic and research potential of the developed photoswitches. Overall, this work provides the first proof of precise control of the therapeutic target β1‐AR in native environments using light.
Ligand‐Controlled NiH‐Catalyzed Regiodivergent Chain‐Walking Hydroalkylation of Alkenes
Authors: Zhao Lei , Zhu Yuqin , Liu Mengyuan , Xie Leipeng , Liang Jimin , Shi Haoran , Meng Xiao , Chen Zhengyang , Han Jian , Wang Chao 
Published: May 2022

AbstractA NiH‐catalyzed migratory hydroalkylation of alkenyl amines with predictable and switchable regioselectivity is reported. By utilizing a ligand‐controlled, directing group‐assisted strategy, various alkyl units are site‐selectively installed at inertsp3C−H sites far away from the original C=C bonds. A range of structurally diverse α‐ and β‐branched protected amines are conveniently synthesized via stabilization of 5‐ and 6‐membered nickelacycles respectively. This method exhibits broad scope and high functional group tolerance, and can be applied to late‐stage modification of medicinally relevant molecules.
Total Synthesis of Complex Peptidyl Nucleoside Antibiotics: Asymmetric De Novo Syntheses of Miharamycin B and Its Biosynthetic Precursor
Authors: Huang Wenjun , Fan Shuai , Gao Jiahui , Luo Shangwen , Tang Shouchu , Liu Jian , Wang Xiaolei 
Published: May 2022

AbstractMiharamycins belong to a class of peptidyl nucleoside antibiotics with a unique nine‐carbon pyranosyl amino acid core and a rare 2‐aminopurine moiety. Herein, we report the de novo total synthesis of miharamycin B and its biosynthetic precursor from 3‐bromofuran and Garner's aldehyde through a modified Achmatowicz reaction. Many challenges were resolved toward the de novo synthesis of miharamycin B, including the introduction of a dense array of functional groups, the stereoselective construction of consecutive stereocenters, dealing with the variability of the anomeric positions, and promoting site‐selectivity in the cyclization to form the tetrahydrofuran ring. This de novo synthesis strategy enables efficient preparation of 3′‐substituted saccharides, allowing the study of their structure–activity relationships and mode of action, and meets the growing demand for the development of novel antibiotics inspired by miharamycin natural products.
Cobalt‐Catalyzed Regio‐, Diastereo‐ and Enantioselective Intermolecular Hydrosilylation of 1,3‐Dienes with Prochiral Silanes
Authors: Wang Lei , Lu Wenxin , Zhang Jiwu , Chong Qinglei , Meng Fanke 
Published: May 2022

AbstractOne of the most straightforward approaches to access chiral silanes is catalytic enantioselective hydrosilylation. Although significant advances have been achieved in enantioselective construction of either a carbon‐stereogenic center or a silicon‐stereogenic center through enantioselective hydrosilylation, simultaneous establishment of a carbon‐ and a silicon‐stereogenic center in an acyclic molecule through a single intermolecular hydrosilylation remained undeveloped. Herein, an unprecedented cobalt‐catalyzed regio‐, diastereo‐ and enantioselective hydrosilylation of 1,3‐dienes is presented, enabling construction of a carbon‐ and a silicon‐stereogenic center in a single intermolecular transformation. A wide range of chiral silanes bearing a carbon‐ and a silicon‐stereogenic center were generated in high efficiency and stereoselectivity. Functionalization of the enantioenriched silanes delivered a variety of valuable chiral building blocks that are otherwise difficult to access.
Dissecting Solvent Effects on Hydrogen Bonding
Authors: Meredith Nicole Y. , Borsley Stefan , Smolyar Ivan V. , Nichol Gary S. , Baker Christopher M. , Ling Kenneth B. , Cockroft Scott L. 
Published: May 2022

AbstractThe experimental isolation of H‐bond energetics from the typically dominant influence of the solvent remains challenging. Here we use synthetic molecular balances to quantify amine/amide H‐bonds in competitive solvents. Over 200 conformational free energy differences were determined using 24 H‐bonding balances in 9 solvents spanning a wide polarity range. The correlations between experimental interaction energies and gas‐phase computed energies exhibited wild solvent‐dependent variation. However, excellent correlations were found between the same computed energies and the experimental data following empirical dissection of solvent effects using Hunter's α/β solvation model. In addition to facilitating the direct comparison of experimental and computational data, changes in the fitted donor and acceptor constants reveal the energetics of secondary local interactions such as competing H‐bonds.
Rhodium(II)‐Catalyzed C(sp3)−H Diamination of Arylcyclobutanes
Authors: Liu Xinyu , Wang Zhifan , Wang Qiwei , Wang Yuanhua 
Published: May 2022

AbstractActivated by multiple consecutive oxidative radical‐polar crossover and desaturation processes, the selective diamination of arylcyclobutanes, which is difficult to perform by classical metallonitrene C−H insertion, was achieved in a short time by rhodium(II) catalysis using N‐fluorobenzenesulfonimide (NFSI) as the oxidant and nitrogen source.
Cobalt‐Catalyzed Asymmetric Sequential Hydroboration/Isomerization/Hydroboration of 2‐Aryl Vinylcyclopropanes
Authors: Chen Chenhui , Wang Hongliang , Li Tongtong , Lu Dongpo , Li Jiajing , Zhang Xie , Hong Xin , Lu Zhan 
Published: May 2022

AbstractA cobalt‐catalyzed asymmetric sequential hydroboration/isomerization/hydroboration of 2‐aryl vinylcyclopropanes was for the first time reported for the preparation of valuable chiral 1,5‐bis(boronates) in good yields with excellent enantioselectivity via asymmetric sequential isomerization/hydroboration of a trisubstituted alkene intermediate. The reaction was carried out smoothly and this protocol was used for asymmetric syntheses of (−)‐preclamol in gram‐scale. The two primary C(sp3)−B bonds in chiral 1,5‐bis(boronates) could be distinguished in iterative Suzuki–Miyaura cross‐coupling reaction, delivering chiral 1,2,5‐triaryl alkanes with excellent enantioselectivity. Based on experimental and computational studies, a cobalt‐hydride species was proposed as the active intermediate in hydroboration, isomerization, and second hydroboration reactions.
Electrochemical Migratory Cyclization of N‐Acylsulfonamides
Authors: Shi Zhaojiang , Li Yuanyuan , Li Nan , Wang Wei‐Zhen , Lu Hao‐Kuan , Yan Hong , Yuan Yaofeng , Zhu Jun , Ye Ke‐Yin 
Published: May 2022

AbstractBenzoxathiazine dioxide, as a bioisostere of the clinically widely used diazoxide, exhibits interesting biological activity. However, limited success has been achieved in terms of its concise and direct synthesis. We report herein a facile electrochemical migratory cyclization of N‐acylsulfonamides to access a diverse array of benzoxathiazine dioxides. The inclusion of electrochemistry is crucial for realizing such a novel transformation, which is substantiated both by the experiments and density‐functional‐theory calculations.
A new ternary Eu(III) β‐diketonate complex with diimine ligand and its application as fluorescent probe for highly sensitive and selective ammonia sensor
Authors: Wang You‐Yu , Song Li , Wang Jian‐Teng , Zhou Yi‐Ming , Dai Ze‐Qi , Liu Wei , Guo Jia‐Yu , Shen Hang‐Yan , Chai Wen‐Xiang 
Published: May 2022

The rapid and accurate detection of ammonia is very important for manufacture and environmental monitoring, which needs to be developed urgently. Herein, a thin film‐based fluorescence sensor is fabricated by using a ternary europium (III) complex probe for ammonia. The new complex Eu(TPM)3(2‐PBO) (1) was designed and synthesized by utilizing a trifluoromethyl substituted β‐diketone ligand TPM and a diimine ligand 2‐PBO (TPM = 1,1,1‐trifluoro‐5,5‐dimethyl‐2,4‐hexanedione, 2‐PBO = 2‐(2′‐pyridyl)‐benzoxazole). This complex probe was synthetically characterized by elemental analysis, crystallographic and spectroscopic analysis, and photoluminescence (PL) study. The crystallographic analysis revealed complex 1 as a neutral complex structure with the Eu(III) center in a distorted square antiprism EuO6N2 coordination polyhedron. Based on this complex probe, a thin film fluorescence sensor with highly sensitive and selective response to ammonia was developed by polymethyl methacrylate (PMMA): complex composite and cellulose paper support. When the paper‐based sensor was exposed to ammonia, its PL emission showed a sensing behavior of rapid quenching. Surprisingly, this new method can achieve excellent limit of detection as low as 2.740 × 10−6 ppm.
Removal of carbon dioxide using zeolitic imidazolate frameworks: Adsorption and conversion via catalysis
Authors: Abdelhamid Hani Nasser 
Published: May 2022

AbstractCarbon dioxide (CO2) is one of the culprit causes of global climatic changes. Furthermore, the efficient separation of CO2 from other gaseous mixtures using zeolitic imidazolate framework (ZIF)‐based materials is vital for several processes such as flue gas separation, gas sweetening, and natural gas processing. ZIF‐based materials are emerging adsorbents and catalysts for CO2 gas removal via adsorption and conversion into valuable chemicals. ZIF‐based adsorbents with high‐adsorption/conversion efficiencies and tunable properties can be achieved by judicious synthesis and fabrication methods. We reviewed ZIF‐based materials for CO2 removal via adsorption and catalysis (e.g., cycloaddition, carboxylation, hydrogenation, N‐formylation, electrocatalysis, and photocatalysis). In addition, recent development methods such as membrane technologies and ways to improve the gas separation performance of ZIF membranes were highlighted. The prospective point of view to promote industrial applications and commercialization of ZIF‐based materials was briefly discussed. Once challenges such as low performance and reproducibility for ZIF‐based materials are solved, scalability and cost‐effectiveness should not become issues.
Preparation and characterization of polyethylene glycol‐based form‐stable phase change materials supported by poly (vinyl formal) foams
Authors: Chen Kexuan , Liu Yuan , He Ren , Wang Qi 
Published: May 2022

AbstractPhase change materials (PCMs) are a kind of materials that provide latent heat at a constant temperature. They have great potential in thermoregulation scopes and thermal energy storage. However, liquid leakage during phase transition restricts their applications in practice severely. In this work, a novel strategy is proposed to prepare form‐stable phase change materials with polyvinyl formal (PVF) foam shape‐stabilized poly (ethylene glycol)‐based material. The PEG exhibits good interfacial compatibility with the PVF framework and the phase transition enthalpy ranges from 104.1 to 158.4 J/g. The PEG/PVF‐C2 increases the residue amount from 0.1% to 4.2% and enhances the thermal degradation temperature at the same time. The mass retention rates of PEG/PVF composites depend on their pore structure, which are 75.4%, 89.5%, and 95.3%, respectively. This study may open a new door for the development of advanced PCMs with good leakage prevention and flame retardancy, thus further contributing to extending the application scopes.