bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of botanical drugs in the treatment of cancer-related fatigue in patients with gastric cancer: A meta-analysis and prediction of potential pharmacological mechanisms
Authors: Wang Ziming , Wu Zihong , Xiang Qiong , Yang Jingyi , Xia Zhenzhong , Hao Aohan , Song Enfeng , Mei Shasha 
Published: September 2022

Objective: To systematically review the efficacy and safety of botanical drugs in the treatment of cancer-related fatigue (CRF) caused by gastric cancer (GC) and to determine the underlying pharmacological mechanisms using a network analysis.Methods: Databases such as China National Knowledge Infrastructure (CNKI), SinoMed, Wanfang, Pubmed, Embase, Cochrane Library, and Web of Science were searched for randomized controlled trials (RCTs) from inception to 18 April 2022. Methodological quality assessment was performed using the collaborative tool Cochrane, and data analysis were carried out using RevMan 5.4 and STATA 16 software. The botanical drugs with the highest frequency of use in the included studies was selected. The chemical composition, targets of action, disease targets, and shared targets of these botanical drugs were screened based on network analysis to explore the potential mechanisms of treating CRF in patients with gastric cancer (GC).Results: A total of 13 studies that included 986 patients with gastric CRF met the inclusion criteria. The results showed that botanical drugs could improve the CRF scores of gastric CRF, including the total scores of CRF dichotomous data [Odds Ratio (OR) = 4.22; 95% confidence interval (CI) 1.67–10.68; p = 0.002], the total scores of CRF continuous data [Standardized Mean Difference (SMD) = -0.98; 95% CI -1.36 to -0.60; p &lt; 0.00001], the affective subscales of Piper Fatigue Scale (PFS) scores [Weighted Mean Difference (MD) = -0.79; 95%CI -0.92 to -0.65; p &lt; 0.00001], the sensory subscales of PFS scores (MD = -0.57; 95%CI -0.77 to -0.37; p &lt; 0.00001), the behavioral subscales of PFS scores (MD = -1.05; 95% CI -1.29 to -0.82; p &lt; 0.00001), Quality of Life Questionnaire Core 30 (QLQ-C30) (MD = 10.53, 95% CI 8.26 to12.80; p &lt; 0.00001), and the Karnofsky Performance Status scale (KPS) (MD = 5.18, 95% CI 2.60 to 7.76; p &lt; 0.0001). The botanical drugs group had milder adverse effects than the control group. A total of 44 chemical components and 241 potential targets were obtained from the online database and 121 drug targets overlapped with the disease targets of CRF in patients with GC. Moreover, five key active ingredients, namely quercetin, Stigmasterol, luteolin, kaempferol, and isorhamnetin, as well as five key targets including AKT1, TP53, TNF, VEGFA, and CASP3, were screened. In addition, five key signaling pathways, including cancer, Hepatitis B, Prostate cancer, Hepatitis C, and Pancreatic cancer pathways, were obtained through enrichment analysis.Conclusion: The results of the study showed that botanical drugs have positive effects on CRF in patients with GC. However, more well-designed, multicenter, and large sample-sized Randomized Controlled Trials are required to evaluate the effectiveness of botanical drugs on CRF in patients with GC.
Deep cooling scheme of quantum degenerate gas and ground experimental verification for chinese space station
Authors: Li Hui , Yu Jiachen , Yuan Xiaolong , Wu Biao , Xie Yu , Li Lin , Liang Angang , Huang Mingshan , Jin Shengjie , Xiong Wei , Wang Bin , Chen Dijun , Li Tang , Hou Xia , Liu Liang , Zhou Xiaoji , Chen Weibiao , Chen Xuzong 
Published: September 2022

The Cold Atom Physics Rack (CAPR) of Chinese space station will be launched at the end of 2022. The important goal of CAPR is to achieve BEC at 100 pk. In order to obtain ultracold atoms in microgravity of space station, we propose a two-stage cooling scheme using all-optical trap with different waist beams. The cold atom cloud obtained by this scheme is composed of condensate and thermal atoms around condensate. The design of our two-stage cooling scheme will effectively reduce the temperature of the thermal atom cloud and the effective temperature generated by the interaction energy of the condensate. The atomic temperature of 5 nk is obtained from the ground test experiment, and the corresponding temperature under the microgravity condition of the space station is theoretically predicted to be less than 100 pk. Taking the advantages of ultracold temperature and long-time detection, many scientific experiments will be arranged. In this paper, the ground test experiments based on ground principle prototype and pre-prototype for CAPR are also introduced.
Keyhole supraorbital eyebrow approach for fully endoscopic resection of tuberculum sellae meningioma
Authors: Zheng Xialin , Shao Dongqi , Li Yu , Cai Longjie , Xie Shan , Sun Zhixiang , Jiang Zhiquan 
Published: September 2022

BackgroundThe fully endoscopic supraorbital trans-eyebrow keyhole approach is a technique utilized for the transcranial resection of tuberculum sellae meningioma (TSM). Surgery is the first choice for TSM treatment. This study aimed to summarize and analyze the safety, feasibility, limitations, and technical requirements of the fully endoscopic supraorbital trans-eyebrow keyhole approach for TSM resection.MethodsData of 19 TSM fully endoscopic supraorbital trans-eyebrow keyhole approach resections cases (six and 13 on the left and right eyebrows, respectively) were retrospectively analyzed at the Neurosurgery Department of the First Affiliated Hospital of Bengbu Medical College (Bengbu, China) from August 2015 to March 2022.ResultsAll 19 patients were diagnosed with meningioma (World Health Organization grade I), and according to the scope of tumor resection (EOR), 18 patients (94.7%) had gross total resection (GTR), and one patient (5.3%) had near-total resection (NTR). Preoperative chief complaints were symptomatic visual dysfunction (n = 12), headache and dizziness (n = 6), and accidental discovery (n = 1). Postoperative visual function improved in 83.3% of cases (10/12), and headache and dizziness were relieved in 83.3% of cases (5/6 patients). Postoperative intracranial infection occurred in one case and was cured by external drainage of the lumbar cistern and anti-infective treatment. Two cases of frontal lobe injury were discharged after conservative treatment. There was no postoperative olfactory dysfunction, eyelid ptosis, cerebrospinal fluid leakage, or death. There were no reports of disease recurrence or death during the 3-month follow-up at an outpatient clinic or by telephone.ConclusionFully endoscopic TSM resection through the keyhole approach is safe and feasible. It can be used to explore angles that cannot be seen under a microscope and show the true value of endoscopy technology. The endoscopic equipment and technical skills of the surgeon and surgical team are important in this technique.
A long waiting time from diagnosis to treatment decreases the survival of non-small cell lung cancer patients with stage IA1: A retrospective study
Authors: Liu Bin , Qian Jia-Yi , Wu Lei-Lei , Zeng Jun-Quan , Xu Shu-Quan , Yuan Jin-Hua , Zheng Yong-Liang , Xie Dong , Chen Xiaolu , Yu Hai-Hong 
Published: September 2022

ObjectiveThe prognostic effect of delayed treatment on stage IA1 non-small cell lung cancer (NSCLC) patients is still unclear. This study aimed to explore the association between the waiting time before treatment and the prognosis in stage IA1 NSCLC patients.MethodsEligible patients diagnosed with pathological stage IA1 NSCLC were included in this study. The clinical endpoints were overall survival (OS) and cancer-specific survival (CSS). The Kaplan-Meier method, the Log-rank test, univariable, and multivariable Cox regression analyses were used in this study. Propensity score matching was used to reduce the bias of data distribution.ResultsThere were eligible 957 patients in the study. The length of waiting time before treatment stratified the survival in patients [&lt;3 months vs. ≥3-months, unadjusted hazard ratio (HR) = 0.481, P = 0.007; &lt;2 months vs. ≥2-months, unadjusted HR = 0.564, P = 0.006; &lt;1 month vs. ≥1-month, unadjusted HR = 0.537, P = 0.001]. The 5-year CSS rates were 95.0% and 77.0% in patients of waiting time within 3 months and over 3 months, respectively. After adjusting for other confounders, the waiting time was identified as an independent prognostic factor.ConclusionsA long waiting time before treatment may decrease the survival of stage IA1 NSCLC patients. We propose that the waiting time for those patients preferably is less than one month and should not exceed two months.
A modified survival model for patients with esophageal squamous cell carcinoma based on lymph nodes: A study based on SEER database and external validation
Authors: Yang Tianbao , Huang Shijie , Chen Boyang , Chen Yahua , Liang Wei 
Published: September 2022

BackgroundThe counts of examined lymph nodes (ELNs) in predicting the prognosis of patients with esophageal squamous cell carcinoma (ESCC) is a controversial issue. We conducted a retrospective study to develop an ELNs-based model to individualize ESCC prognosis.MethodsPatients with ESCC from the SEER database and our center were strictly screened. The optimal threshold value was determine by the X-tile software. A prognostic model for ESCC patients was developed and validated with R. The model’s efficacy was evaluated by C-index, ROC curve, and decision curve analysis (DCA).Results3,629 cases and 286 cases were screened from the SEER database and our center, respectively. The optimal cut-off value of ELNs was 10. Based on this, we constructed a model with a favorable C-index (training group: 0.708; external group 1: 0.687; external group 2: 0.652). The model performance evaluated with ROC curve is still reliable among the groups. 1-year AUC for nomogram in three groups (i.e., 0.753, 0.761, and 0.686) were superior to that of the TNM stage (P &lt; 0.05). Similarly, the 3-year AUC and the 5-year AUC results for the model were also higher than that of the 8th TNM stage. By contrast, DCA showed the benefit of this model was better in the same follow-up period.ConclusionMore than 10 ELNs are helpful to evaluate the survival of ESCC patients. Based on this, an improved model for predicting the prognosis of ESCC patients was proposed.
Retrieval of Live Fuel Moisture Content Based on Multi-Source Remote Sensing Data and Ensemble Deep Learning Model
Authors: Xie Jiangjian , Qi Tao , Hu Wanjun , Huang Huaguo , Chen Beibei , Zhang Junguo 
Published: September 2022

Live fuel moisture content (LFMC) is an important index used to evaluate the wildfire risk and fire spread rate. In order to further improve the retrieval accuracy, two ensemble models combining deep learning models were proposed. One is a stacking ensemble model based on LSTM, TCN and LSTM-TCN models, and the other is an Adaboost ensemble model based on the LSTM-TCN model. Measured LFMC data, MODIS, Landsat-8, Sentinel-1 remote sensing data and auxiliary data such as canopy height and land cover of the forest-fire-prone areas in the Western United States, were selected for our study, and the retrieval results of different models with different groups of remote sensing data were compared. The results show that using multi-source data can integrate the advantages of different types of remote sensing data, resulting in higher accuracy of LFMC retrieval than that of single-source remote sensing data. The ensemble models can better extract the nonlinear relationship between LFMC and remote sensing data, and the stacking ensemble model with all the MODIS, Landsat-8 and Sentinel-1 remote sensing data achieved the best LFMC retrieval results, with R2 = 0.85, RMSE = 18.88 and ubRMSE = 17.99. The proposed stacking ensemble model is more suitable for LFMC retrieval than the existing method.
Análise do perfil dos pacientes oncológicos admitidos em unidades hospitalares do Espírito Santo (ES) e de seus fatores protetores e de risco em relação ao cenário nacional no período de 2000 a 2019
Authors: Grillo Marina Bermudes , Brito Shaira Salvador Cunha , Marinot Júlia Bravim , Grillo Claudia Helena Bermudes , Szpilman Ana Rosa Murad 
Published: September 2022

Introdução: O câncer, doença crônica não transmissível, é apontado como um dos principais problemas de saúde mundialmente. Essa afecção tem alcançado uma crescente importância nas discussões em escala global, visto que é notório o aumento das taxas de prevalência e de incidência de seus inúmeros tipos de malignidade, sendo confirmadas pelas curvas de morbimortalidades que tendem a crescer ascendentemente tanto no Brasil, quanto nos outros países. Objetivo: Analisar o perfil dos pacientes oncológicos admitidos em unidades hospitalares do Espírito Santo (ES) e de seus fatores protetores e de risco em relação ao cenário nacional no período de 2000 a 2019. Métodos: Estudo observacional longitudinal retrospectivo com abordagem quantitativa e qualitativa realizado a partir da amostra de dados de pacientes oncológicos admitidos em unidades hospitalares do estado do Espírito Santo no período de 2000 a 2019. A coleta ocorreu por meio do Portal do Departamento de Informática do SUS (DATASUS) e do Integrador de Registros Hospitalares do Câncer (RHC), desenvolvido pelo Instituto Nacional de Câncer (INCA). A análise foi realizada por meio do programa Excel 2020. Oo estudo atendeu aos critérios éticos de pesquisa com seres humanos e foi submetido e aprovado pelo Comitê de Ética em pesquisa. Resultados: 100.247 pacientes, maioria mulheres, entre 60 e 69 anos, casados, pardos. A principal localização primária do tumor foi pele, seguida de aparelho digestivo, urológicos e de mamas. Entre a maioria das localizações primárias do tumor, ocorre predomínio do sexo masculino, a partir da quinta década de vida, brancos e pardos, sem informações sobre histórico familiar. Quando avaliado histórico patológico pregresso, a maioria dos pacientes relatou ausência de diagnóstico e de tratamento prévio. Com relação ao consumo de álcool e tabaco, é de grande predomínio a ausência de informação em relação ao histórico e o relato de ausência de ingesta. Conclusão: A caracterização da prevalência dos subtipos oncológicos mais comumente encontrados e o estabelecimento do perfil dos pacientes do setor oncológico admitido nas unidades hospitalares no estado do Espírito Santo e no Brasil é de suma importância para a promoção da monitorização e controle do status da saúde oncológica, e de seus fatores de risco e de proteção. Assim, a partir do perfil epidemiológico estabelecido e dos fatores correlacionados, torna-se imperativo o planejamento e a tomada de ações que proporcionem o rastreio e o diagnóstico precoce de tais enfermidades, a fim de proporcionar maior longevidade e garantir melhor qualidade de vida aos pacientes portadores.
Ultrassom FAST- aplicabilidade em pacientes hemodinamicamente instáveis na emergência
Authors: Melo Bárbara , Lopes Henrique Afonso , Carpaneda Jessica de Medeiros , Moraes José Antônio Carvalho Ferreira , Barbosa Auriane Bueno , Bezzan Isadora Godoy Brambilla , Canedo Isabella Sales Nogueira Amorim , Guimarães Bruna Freitas 
Published: September 2022

Objetivo: Compreender a importância do uso do FAST e eFAST como meio diagnóstico e conduta no paciente hemodinamicamente instável vítima de trauma. Método: Trata-se de uma revisão sistemática realizada através da pesquisa no banco de dados BVS com acesso ao PubMed, Medline e SciElo, entre o período de 2009 a 2022. Resultados: Foram selecionados 11 artigos que abordavam de forma detalhada o tema proposto. Desta analise pode-se entender a facilidade da ultrassonografia beira leito como método diagnóstico de líquido livre intra-abdominal e achados de trauma torácico em pacientes instáveis hemodinamicamente, com alta sensibilidade e especificidade, evitando-se procedimentos invasivos desnecessários. Conclusão: Entende-se por fim que a utilização do FAST e o eFAST auxiliam no diagnóstico inicial do paciente vítima de trauma e de forma mais rápida e barata que a utilização da tomografia computadorizada.
Aspectos anatomopatológicos do paciente portador de Pneumonia
Authors: Da Luz Kaiza Vilarinho , Schultheis Stephanie Ferro , Meneses Alyce Garcia , De França Ricardo Mesquita , Da Silva Anderson Ricardo Cantareli , Padilha Jamilly Alves , Lopes Jessica Reis , Rezende Soraya de Paula Almeida , De Rezende Erval Antônio , De Oliveira Júnior Severino Veras , Da Silva Patricia Vastres Vieira , Pena Carlos Felype de Oliveira , Leite Matheus Bezerra Camelo , Taumaturgo Gabriel Castro , Campos José Rodolfo Rocha , Luciano Waléria Vidal , Luciano Thaís Vidal , Silva Endy Souza , França Israel de Lima , Castro Anna Paulla de Carvalho do Nascimento , De Abrantes Ailton Gomes , Kelher Igor Furlan , Calabria André Chaves , Goulart Luiz Paulo Mendonça , Leite Deivam São Leão , Dias Valentina Morais , Da Silva Mizael , Moreno Jenny Maldonado , Cavalcante Rafael Leituga de Carvalho , Checchinato Daniel , Dantas Erly Fernando Ferreira , Dos Santos Adelcio Machado 
Published: September 2022

A pneumonia condiz a uma condensação inflamatória aguda dos alvéolos e/ou infiltração tecidual intersticial pulmonar que resulta da ação de células inflamatórias em resposta a injúrias de um determinado agente microbiano. A patologia conforme o local de aquisição, o padrão de comprometimento, o agente etiológico são determinantes para o quadro clínico, lesões e achados radiográficos. O seguinte artigo objetivou descrever através da revisão bibliográfica, os aspectos gerais da pneumonia com foco em abordar os aspectos anatomopatológicos desta enfermidade. Trata-se de um estudo qualitativo de revisão narrativa, elaborado para abordar sobre os aspectos anatomopatológicos do paciente portador de pneumonia. É composta por uma análise ampla da literatura, e com uma metodologia rigorosa e replicável ao nível de reprodução de dados e questões quantitativas para resoluções específicas. Conforme as informações disponíveis na literatura, elucida-se que os pulmões contam com um aparato de mecanismos de defesa. Mas, mediante injúrias e agentes agressores geram um desequilíbrios e posteriormente originam condições que favorecem doenças respiratórias. A pneumonia possui vários agentes etiológicos, e de acordo com este, distintos padrões de acometimento pulmonar e achados radiográficos irão se manifestar.
General Specification for Simulating Universe
Authors: Yoon Jihyeon 
Published: September 2022

<p>In this paper, a direct general specification for simulating an entire universe would be given. The simulation would be targeted as same as maximally having physical considerations in reality.</p>
<p>Background: By identifying the universal attributes of basic attributes in an universe, scientific proposition of creating simulated universe could be derived.</p>
<p>Methods: By extending the Monty Hall Problem derived from the result of P vs NP Problem and Game Theory to the understanding of a single observation, the continuum of total observation events creates a distribution of probability which could be translated into distribution of possibility. And using from what has been defined in this universe, methods of utilizing simulation of reality could be described.</p>
<p>Results: Technical specification for creating axiomatic universe in existing universe could be described.</p>
<p>Conclusions: In generalized terms, simulated universe could exist with a customized reality. </p>
General Specification for Simulating Universe
Authors: Yoon Jihyeon 
Published: September 2022

<p>In this paper, a direct general specification for simulating an entire universe would be given. The simulation would be targeted as same as maximally having physical considerations in reality.</p>
<p><br></p>
<p>Background: By identifying the universal attributes of basic attributes in an universe, scientific proposition of creating simulated universe could be derived.</p>
<p><br></p>
<p>Methods: By extending the Monty Hall Problem derived from the result of P vs NP Problem and Game Theory to the understanding of a single observation, the continuum of total observation events creates a distribution of probability which could be translated into distribution of possibility. And using from what has been defined in this universe, methods of utilizing simulation of reality could be described.</p>
<p><br></p>
<p>Results: Technical specification for creating axiomatic universe in existing universe could be described.</p>
<p><br></p>
<p>Conclusions: In generalized terms, simulated universe could exist with a customized reality. </p>
Pengaruh Media Sosial Instagram Untuk Anak Special Needs
Authors: Nurul Hafsyah Ilmi , Oktaviani Femi 
Published: September 2022

Digitalisasi banyak menimbulkan media baru salah satunya, media sosial yang membawa perubahan komunikasi. Sehingga, dengan mengekspresi diri pada media sosial membuat orang akan merasa diterima oleh lingkungannya, sebagaimana telah disebut satu dari lima pilar teori kebutuhan Abraham Maslow adalah aktualisasi diri.Instagram adalh medis yang digunakan. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian kuantitatif dengan metode Survey . Dimana melihat hasil anak special needs yang telah menggunakan media sosial instagram dan yang belum menggunakan media sosial instagram untuk mengetahui bagaimana peran media sosial instagram dalam memberikan kebutuhan kepuasan dalam mengaktualisasi diri pada anak spesial needs (HW, 2013). Untuk mengetahui bagaimana interaksi anak special needs SLB – b Sukapura dalam menggunakan media sosial instagram, yang memilki jumlah total siswa –siswi 45 orang.. Nilai ini mengandung arti bahwa pengaruh media sosial instagram (X) terhadap aktualisasi diri anak special needs (Y) adalah sebesar 46% sedangkan 54% aktualisasi diri anak Special Needs dipengaruhi oleh variabel lain.adanya hubungan antara siswa- siswi sekolah SLB - B Sukapura Bandung terhadap penggunaan instargram sebagai aktualiasasi, diterima. Dengan demikian dapat dijelaskan bahwa aktualisasi diri siswa- siswi Sekolah SLB – b Sukapura Bandung . sekolah dipengaruhi oleh penggunaan media sosial instagram sebesar 46%. Hal tersebut menjelaskan pula, bahwa aktualisasi diri siswa –siswi Sekolah SLB – b Sukapura Bandung dapat dipengaruhi oleh faktor – faktor lain, dan faktor – faktor lain selain penggunaan media sosial instagram tersebut berpengaruh sebesar 54% terhadap aktualisasi mereka di sekolah.
Analisis Yuridis Penegakan Hukum Bagi Masyarakat Yang Membuang Sampah Sembarangan di DKI Jakarta Sebagai Dampak Pencemaran Lingkungan Hidup
Authors: Yulia Tri 
Published: September 2022

Polemik sampah yang dihadapi DKI Jakarta sebagai akibat kurangnya kesadaran masyarakat dalam membuang sampah yang tidak pada tempat, walaupun Dinas Lingkungan Hidup Pemda DKI Jakarta telah menerbitkan 2 (dua) aturan hukum peraturan daerah yaitu Perda Nomor 3 Tahun 2013 tentang Pengelolaan Sampah dan Perda Nomor 8 Tahun 2007 tentang Ketertiban Umum, namun tetap saja masih ada masyarakat Ibukota yang melanggar aturan tersebut. Tujuan Penelitian ini adalah untuk mengetahui dan menganalisa secara yuridis Penegakan Hukum Bagi Masyarakat Yang Membuang Sampah Sembarangan Di DKI Jakarta sebagai dampak pencemaran lingkungan hidup dan Upaya Pemda DKI Jakarta dalam memberikan Kesadaran Hukum Terhadap masyarakat yang membuang sampah sembarangan dalam rangka tertib hukum. Jenis penelitian yang penulis gunakan adalah penelitian yuridis normatif dan penelitian yuridis empiris. Penulis menyimpulkan bahwa penegakkan hukum yang dilakukan terhadap masyarakat yang membuang sampah sembarangan di DKI Jakarta melalui Ketentuan yang terdapat dalam Perda Nomor 3 Tahun 2013 tentang Pengelolaan Sampah, sanksi yang diterapkan terhadap masyarakat yang membuang sampah sembarangan adalah sanksi administratif sedangkan ketentuan pada Perda Nomor 8 Tahun 2007 tentang Ketertiban Umum, terhadap masyarakat yang membuang sampah sembarangan yang terdapat dalam pasal 61 dan 64 termasuk pada pidana pelanggaran, bukan kejahatan.