bluuebunny/crossref_metadata_2025_split huggingface dataset:
6‐Methoxy‐1‐tetralone Derivatives Bearing an N‐Arylpyridinium Moiety as Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Molecular Docking Study
Authors: Chehardoli Gholamabbas , Gholamhoseini Pooriya , Ebadi Ahmad , Ziaei Maral , Akbarzadeh Tahmineh , Saeedi Mina , Mahdavi Mohammad , Khoshneviszadeh Mehdi , Najafi Zahra 
Published: July 2022

AbstractA novel series of 6‐methoxy‐1‐tetralone derivatives bearing N‐aryl pyridinium moiety were designed, synthesized, and evaluated as acetyl and butyrylcholinesterase inhibitors. The designed derivatives inhibited acetylcholinesterase (AChE) with IC50 values of 0.025–23.743 μM and butyrylcholinesterase (BChE) with IC50 values of 0.716–20.588 μM. The synthesized compounds were divided into two series. Derivatives containing N‐benzyl moieties generally were more potent anti‐AChE and anti‐BChE agents than compounds with N‐alkylphthalimide groups. Among them, the compound (E)‐1‐Benzyl‐3‐((6‐methoxy‐1‐oxo‐3,4‐dihydronaphthalen‐2(1H)‐ylidene)methyl)pyridin‐1‐ium bromide (5 a) and compound (E)‐1‐(3‐Chlorobenzyl)‐3‐((6‐methoxy‐1‐oxo‐3,4‐dihydronaphthalen‐2(1H)‐ylidene)methyl)pyridin‐1‐ium bromide (5 d) exhibited significant inhibitory activity against AChE and BChE with IC50 values of 0.025 and 0.716 μM in comparison to donepezil as a reference drug (0.029 and 0.948 μM, respectively). The results of kinetic and molecular modeling studies demonstrated that the synthesized compounds 5 a and 5 d derivatives can act as mixed and dual binding inhibitors, and bind to both CAS and PAS of AChE and BChE enzymes. Among the assessed compounds, the compound 5 a indicated significant neuroprotection against H2O2‐induced cell death in PC12 cells. So, these findings indicate the therapeutic potential of 6‐methoxy‐1‐tetralone derivatives bearing N‐aryl pyridinium moiety derivatives as anti‐AD agents.
Wearable SERS Sensor Based on Omnidirectional Plasmonic Nanovoids Array with Ultra‐High Sensitivity and Stability
Authors: Zhu Kai , Yang Kuo , Zhang Yizhi , Yang Zhaoyan , Qian Ziting , Li Na , Li Lang , Jiang Guohua , Wang Tingyu , Zong Shenfei , Wu Lei , Wang Zhuyuan , Cui Yiping 
Published: July 2022

AbstractSurface‐enhanced Raman spectroscopy (SERS) is a promising technology for wearable sensors due to its fingerprint spectrum and high detection sensitivity. However, since SERS‐activity is sensitive to both the distribution of “hotspots” and excitation angle, it is profoundly challenging to develop a wearable SERS sensor with high stability under various deformations during movements. Herein, inspired by omnidirectional light‐harvesting of the compound eye of Xenos Peckii, a wearable SERS sensor is developed using omnidirectional plasmonic nanovoids array (OPNA), which is prepared by assembling a monolayer of metal nanoparticles into the artificial plasmonic compound‐eye (APC). Specifically, APC is an interconnected frame containing omnidirectional “pockets” and acts as an “armour”, not only rendering a broadband and omnidirectional enhancement of “hotspots” in the delicate nanoparticles array, but also maintaining an integrity of the “hotspots” against external mechanical deformations. Furthermore, an asymmetry super‐hydrophilic pattern is fabricated on the surface of OPNA, endowing the hydrophobic OPNA with the ability to spontaneously extract and concentrate the analytes from sweat. Such an armored SERS sensor can enable the wearable and in situ analysis with high sensitivity and stability, exhibiting great potential in point‐of‐care analysis.
An Injectable Hydrogel to Modulate T Cells for Cancer Immunotherapy
Authors: Zhang Di , Li Qian , Chen Xiangwu , Nie Xinxin , Xue Fumin , Xu Wei , Luan Yuxia 
Published: July 2022

AbstractT cell exhaustion caused by mitochondrial dysfunction is the major obstacle of T cells‐based cancer immunotherapy. Besides exhausted T cells, the insufficient major histocompatibility complex class I (MHC I) on tumor cells leads to inefficient T cell recognition of tumor cells, compromising therapeutic efficacy. Therapeutic platform to regulate T cell exhaustion and MHC I expression for boosting T cells‐based cancer immunotherapy has not been realized up to date. Herein, an injectable hydrogel is designed to simultaneously tune T cell exhaustion and MHC I expression for amplified cancer immunotherapy. The hydrogel is in situ constructed in tumor site by utilizing oxidized sodium alginate‐modified tumor cell membrane vesicle (O‐TMV) as a gelator, where axitinib is encapsulated in the lipid bilayer of O‐TMV while 4‐1BB antibody and proprotein convertase subtilisin/kexin type 9 inhibitor PF‐06446846 nanoparticles are present in the cavities of hydrogel. After immune response trigged by O‐TMV antigen, the 4‐1BB antibody‐promoted T cell mitochondrial biogenesis and the axitinib‐lowered hypoxia synergistically reverse T cell exhaustion while the PF‐06446846‐amplified MHC I expression facilitates T cell recognition of tumor cells, demonstrating a powerful immunotherapeutic efficacy. This strategy on reprograming T cell exhaustion and improving T cell potency offers new concept for T cells‐based cancer immunotherapy.
High Operation Frequency and Strain Tolerance of Fully Printed Oxide Thin Film Transistors and Circuits on PET Substrates
Authors: Divya Mitta , Pradhan Jyoti Ranjan , Priyadarsini Sushree Sangita , Dasgupta Subho 
Published: July 2022

AbstractThe major limitations of solution‐processed oxide electronics include high process temperatures and the absence of necessary strain tolerance that would be essential for flexible electronic applications. Here, a combination of low temperature (<100 °C) curable indium oxide nanoparticle ink and a conductive silver nanoink, which are used to fabricate fully‐printed narrow‐channel thin film transistors (TFTs) on polyethylene terephthalate (PET) substrates, is proposed. The metal ink is printed onto the In2O3 nanoparticulate channel to narrow the effective channel lengths down to the thickness of the In2O3 layer and thereby obtain near‐vertical transport across the semiconductor layer. The TFTs thus prepared show On/Off ratio ≈106 and simultaneous maximum current density of 172 µA µm−1. Next, the depletion‐load inverters fabricated on PET substrates demonstrate signal gain >200 and operation frequency >300 kHz at low operation voltage of VDD = 2 V. In addition, the near‐vertical transport across the semiconductor layer is found to be largely strain tolerant with insignificant change in the TFT and inverter performance observed under bending fatigue tests performed down to a bending radius of 1.5 mm, which translates to a strain value of 5%. The devices are also found to be robust against atmospheric exposure when remeasured after a month.
Biodegradable Hollow‐Structured Nanozymes Modulate Phenotypic Polarization of Macrophages and Relieve Hypoxia for Treatment of Osteoarthritis
Authors: Xiong Hao , Zhao Yongzheng , Xu Qinyuan , Xie Xue , Wu Jianrong , Hu Bing , Chen Shuai , Cai Xiaojun , Zheng Yuanyi , Fan Cunyi 
Published: July 2022

AbstractNanozymes are widely applied for treating various major diseases, including neurological diseases and tumors. However, the biodegradability of nanozymes remains a great challenge, which hinders their further clinical translation. Based on the microenvironment of osteoarthritis (OA), a representative pH‐responsive biodegradable hollow‐structured manganese Prussian blue nanozyme (HMPBzyme) is designed and applied for treatment of OA. HMPBzyme with good pH‐responsive biodegradability, biocompatibility, and multi‐enzyme activities is constructed by bovine serum albumin bubbles as a template‐mediated biomineralization strategy. HMPBzyme suppresses hypoxia‐inducible factor‐1α (HIF‐1α) expression and decreases reactive oxygen species (ROS) level in the in vitro experiment. Furthermore, HMPBzyme markedly suppresses the expression of ROS and alleviates the degeneration of cartilage in OA rat models. The results indicate that the biodegradable HMPBzyme inhibits oxidative damage and relieves hypoxia synergistically to suppress inflammation and promote the anabolism of cartilage extracellular matrix by protecting mitochondrial function and down‐regulating the expression of HIF‐1α, which modulates the phenotypic conversion of macrophages from pro‐inflammatory M1 subtype to anti‐inflammatory M2 subtype for OA treatment. This research lays a solid foundation for the design, construction, and biomedical application of biodegradable nanozymes and promotes the application of nanozymes in biomedicine.
Approaches to Enhancing Electrical Conductivity of Pristine Metal–Organic Frameworks for Supercapacitor Applications
Authors: Wang Teng , Lei Jiaqi , Wang You , Pang Le , Pan Fuping , Chen Kai‐Jie , Wang Hongxia 
Published: July 2022

AbstractMetal–organic frameworks (MOFs), known as porous coordination polymers, have attracted intense interest as electrode materials for supercapacitors (SCs) owing to their advantageous features including high surface area, tunable porous structure, structural diversity, etc. However, the insulating nature of most MOFs has impeded their further electrochemical applications. A common solution for this issue is to transform pristine MOFs into more stable and conductive metal compounds/porous carbon materials through pyrolysis, which however losses the inherent merits of MOFs. To find a consummate solution, recently a surge of research devoted to improving the electrical conductivity of pristine MOFs for SCs has been carried out. In this review, the most related research work on pristine MOF‐based materials is reviewed and three effective strategies (chemical structure design of conductive MOFs (c‐MOFs), composite design, and binder‐free structure design) which can significantly increase their conductivity and consequently the electrochemical performance in SCs are proposed. The conductivity enhancement mechanism in each approach is well analyzed. The representative research works on using pristine MOFs for SCs are also critically discussed. It is hoped that the new insights can provide guidance for developing high‐performance electrode materials based on pristine MOFs with high conductivity for SCs in the future.
A tetrahedral model of autobiographical memory research design
Authors: Talarico Jennifer M. 
Published: July 2022

AbstractThe field of autobiographical memory can do more to be representative of global populations experiencing and recollecting diverse events across the lifespan. To inspire such work, I present a general model for designing autobiographical memory studies. The tetrahedral model (based on Jenkins, 1979) has at its vertices context (e.g., the situated environment, activated schema, or functional goal), outcomes (e.g., the content and phenomenology of remembering), participants (e.g., the demographic characteristics and traits of the individual), and events (e.g., the lived experiences that comprise an individual's autobiography). Further, the area of the base of the pyramid can represent the time frame under investigation (e.g., the wider the distance, the greater the delay between an experience and its retrieval) and the height of the pyramid can represent the sample size (e.g., nearly flat for a case study, increasingly taller for larger groups) being studied. After applying the model to describe how typical autobiographical memory research is conducted (and briefly identifying the limitations therein), representative models of particularly promising areas of research are highlighted.This article is categorized under:
Psychology > Memory
Travelling Leadership Ideas as a Business Virus
Authors: Jevnaker Birgit Helene , Olaisen Johan 
Published: July 2022

AbstractVirtually identical management ideas seem to crop up simultaneously in similar organizations globally, in what ways can this phenomenon be understood? Leaders in organizations may play a more active role than those often depicted in the management fashion theory. The encounter between thought and practice may be lasting; beliefs may affect training and practice. The ideas may represent a trade-off between business strategy, leadership, and employees. We keep acceptable and adequate ideas while we drop unacceptable and inadequate plans. The ideas work like a sensitizing concept of directions along which to look for temporary order and stability, as well as potential change. Adopting a business idea is like a virus spreading worldwide, leaving an enormous impact through global corporations and societies. In this chapter, we study management ideas in a selection of top Scandinavian corporations to generate and discuss 8 relevant hypotheses. The same ideas might reach public institutions like universities and hospitals. In public institutions, they might present as a form of New Public Management or merely a way of managing, e.g. universities or hospitals through a magic business virus, creating what looks like similar strategies found in private businesses.
Possibilities and Missing Links in Management Research: What We Do Not Know That We Know
Authors: Jevnaker Birgit Helene , Olaisen Johan 
Published: July 2022

AbstractThe purpose of this chapter is to address possibilities and missing links by looking into some contemporary knowledge management research. For this aim we analyse and compare all the papers in the proceedings ofEuropean Conference on Knowledge Management(ECKM) in Barcelona (2017), Padua (2018), Lisbon (2019), and the digital conference in 2020. The approach uses a philosophy of science framework and compares this to the content of the research papers. We will discuss the findings in four representations of knowledge, two typologies of concepts, and four paradigmatic classifications to open up for creative future explorations in knowledge management research. The results indicate a conference based upon as-is knowledge and less upon new and often unsolvable problems. There are however more critical and green papers in the 2020 conference opening up for new perspectives in the choice of methodology, problems, and knowledge.
Management as Power and Politics in Projects
Authors: Jevnaker Birgit Helene , Olaisen Johan 
Published: July 2022

AbstractIn this chapter, we explore what impact do micropolitics and power have upon the conduct of project management in an organization? Drawing on interviews with project managers of four oil and gas firms, we discuss how the informal power and micropolitics played a massive role in the projects, and personal and relational knowledge appeared to achieve the expected project results. Power and micropolitics were regarded as necessary skills and tools for a successful project manager. A democratic and consensus-oriented culture opens for power games and micropolitics rather than hedging them. Compared to more hierarchical organizations, informal micropolitics and power mean a high potential to prolong and complicate decision processes and significantly reduce efficiency. The theoretical implication is a general model for power and micropolitics, while the practical implication understands how crucial informal power and micropolitics are in projects.
Quark and gluon helicity evolution at small x: revised and updated
Authors: Cougoulic Florian , Kovchegov Yuri V. , Tarasov Andrey , Tawabutr Yossathorn 
Published: July 2022

Abstract
We revisit the problem of small Bjorken-x evolution of the gluon and flavor-singlet quark helicity distributions in the shock wave (s-channel) formalism. Earlier works on the subject in the same framework [1–3] resulted in an evolution equation for the gluon field-strength F12 and quark “axial current” $$ \overline{\psi}\gamma $$

ψ
¯

γ
+γ5ψ operators (sandwiched between the appropriate light-cone Wilson lines) in the double-logarithmic approximation (summing powers of αs ln2(1/x) with αs the strong coupling constant). In this work, we observe that an important mixing of the above operators with another gluon operator, $$ {}_D{}^{\leftarrow i} $$

D

←
i

Di, also sandwiched between the light-cone Wilson lines (with the repeated transverse index i = 1, 2 summed over), was missing in the previous works [1–3]. This operator has the physical meaning of the sub-eikonal (covariant) phase: its contribution to helicity evolution is shown to be proportional to another sub-eikonal operator, Di − $$ {}_D{}^{\leftarrow i} $$

D

←
i

, which is related to the Jaffe-Manohar polarized gluon distribution [4]. In this work we include this new operator into small-x helicity evolution, and construct novel evolution equations mixing all three operators (Di − $$ {}_D{}^{\leftarrow i} $$

D

←
i

, F12, and $$ \overline{\psi}\gamma $$

ψ
¯

γ
+γ5ψ), generalizing the results of [1–3]. We also construct closed double-logarithmic evolution equations in the large-Nc and large-Nc&Nf limits, with Nc and Nf the numbers of quark colors and flavors, respectively. Solving the large-Nc equations numerically we obtain the following small-x asymptotics of the quark and gluon helicity distributions ∆Σ and ∆G, along with the g1 structure function,$$ \Delta \Sigma \left(x,{Q}^2\right)\sim \Delta G\left(x,{Q}^2\right)\sim {g}_1\left(x,{Q}^2\right)\sim {\left(\frac{1}{x}\right)}^{3.66\sqrt{\frac{\alpha_s{N}_c}{2\pi }}} $$
∆
Σ

x

Q
2

∼
∆
G

x

Q
2

∼

g
1

x

Q
2

∼

1
x

3.66

α
s

N
c

2
π

in complete agreement with the earlier work by Bartels, Ermolaev and Ryskin [5].
Diagnostic Accuracy of the Eating Assessment Tool-10 (EAT-10) in Screening Dysphagia: A Systematic Review and Meta-Analysis
Authors: Zhang Ping-ping , Yuan Ying , Lu De-zhi , Li Ting-ting , Zhang Hui , Wang Hong-ying , Wang Xiao-wen 
Published: July 2022

AbstractThe Eating Assessment Tool-10 (EAT-10) is used worldwide to screen people quickly and easily at high risk for swallowing disorders. However, the best EAT-10 cutoff value is still controversial. In this systematic review and meta-analysis, we estimated and compared the diagnostic accuracy of EAT-10 cutoff values of 2 and 3 for screening dysphagia. We searched the PubMed, Web of Science, EMBASE, Cochrane Library, CNKI, WANFANG, and VIP databases from May 2008 to March 2022. The meta-analysis included 7 studies involving 1064 subjects from 7 different countries. Two studies were classified as high quality and five studies as medium quality. With an EAT-10 cutoff value of 2, using flexible endoscopic evaluation of swallowing or video fluoroscopic swallowing study as the gold standard, the pooled sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio were 0.89 (95% confidence interval [CI] 0.82–0.93), 0.59 (95% CI 0.39–0.77), 2.17 (95% CI 1.38–3.42), 0.19 (95% CI 0.13–0.29), and 11.49 (95% CI 5.86–22.53), respectively. When a cutoff of 3 was used, these values were 0.85 (95% CI 0.68–0.94), 0.82 (95% CI 0.65–0.92), 4.84 (95% CI 1.72–13.50), 0.18 (95% CI 0.07–0.46), and 26.24 (95% CI 5.06–135.95), respectively. Using EAT-10 cutoff values of 2 and 3, the areas under the curve were 0.873 (95% CI 0.82–0.93) and 0.903 (95% CI 0.88–0.93), respectively, showing good diagnostic performance. EAT-10 can be used as a preliminary screening tool for dysphagia. However, a cutoff of 3 is recommended for EAT-10 due to better diagnostic accuracy.
Hybrid of monolithic and staggered solution techniques for the computational analysis of fracture, assessed on fibrous network mechanics
Authors: Tojaga Vedad , Kulachenko Artem , Östlund Sören , Gasser T. Christian 
Published: July 2022

AbstractThe computational analysis of fiber network fracture is an emerging field with application to paper, rubber-like materials, hydrogels, soft biological tissue, and composites. Fiber networks are often described as probabilistic structures of interacting one-dimensional elements, such as truss-bars and beams. Failure may then be modeled as strong discontinuities in the displacement field that are directly embedded within the structural finite elements. As for other strain-softening materials, the tangent stiffness matrix can be non-positive definite, which diminishes the robustness of the solution of the coupled (monolithic) two-field problem. Its uncoupling, and thus the use of a staggered solution method where the field variables are solved alternatingly, avoids such difficulties and results in a stable, but sub-optimally converging solution method. In the present work, we evaluate the staggered against the monolithic solution approach and assess their computational performance in the analysis of fiber network failure. We then propose a hybrid solution technique that optimizes the performance and robustness of the computational analysis. It represents a matrix regularization technique that retains a positive definite element stiffness matrix while approaching the tangent stiffness matrix of the monolithic problem. Given the problems investigated in this work, the hybrid solution approach is up to 30 times faster than the staggered approach, where its superiority is most pronounced at large loading increments. The approach is general and may also accelerate the computational analysis of other failure problems.
Tiefenorientierte Pumpversuche zur Bestimmung der hydraulischen Anisotropie in einem geschichteten Grundwasserleiter
Authors: Maier Ruth , Leven Carsten , Strasser Daniel , Odenwald Bernhard , Cirpka Olaf A. 
Published: July 2022

ZusammenfassungDie horizontale Schichtung von Sedimentkörpern bewirkt, dass die effektive hydraulische Durchlässigkeit eines sedimentären Grundwasserleiters in horizontaler Richtung größer ist als in der vertikalen, was sich unter anderem auf die Ausbreitung des Absenktrichters bei Grundwasserentnahmen auswirkt. Um die großräumige hydraulische Anisotropie zu bestimmen, führten Maier et al. (2022a) an einem Testfeld am Oberrhein tiefenorientierte Pumpversuche mit einem Förderbrunnen mit drei Filterstrecken durch. Die Grundwasserentnahmen erfolgten nacheinander jeweils aus einer Tiefe. Die Absenkungen aller Versuche wurden in verschiedenen Abständen zum Förderbrunnen und verschiedenen Tiefen gemessen und gemeinsam mit einem Computermodell ausgewertet. In der vorliegenden Arbeit zeigen wir, dass die Interpretation von Absenkkurven bei Entnahme aus nur einer Tiefe zu Durchlässigkeitsbeiwerten führt, die vornehmlich die Bedingungen in der Entnahmetiefe widerspiegeln. Für die Bestimmung vertikaler Unterschiede der hydraulischen Durchlässigkeit und der hydraulischen Anisotropie ist es notwendig, Versuche mit mehreren Entnahmetiefen zu kombinieren. Der Arbeitsaufwand im Feld kann jedoch durch eine optimierte Beobachtungsstrategie reduziert werden.