bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi‐fault diagnosis method based on improved SMOTE for class‐imbalanced data
Authors: Xu Yuan , Zhao Yang , Ke Wei , He Yan‐Lin , Zhu Qun‐Xiong , Zhang Yang , Cheng Xiaoqian 
Published: August 2022

AbstractWith the development of industrial processes, how to effectively diagnose the faults in an increasingly complex production process has attracted widespread attention. It is worth noting that there may be multiple types of faults in the actual industrial process, and there is an extreme class imbalance between the normal samples and the fault samples. Therefore, it is of practical significance to carry out research on the multi‐fault diagnosis method for class‐imbalanced data. In this paper, a multi‐fault diagnosis method based on improved synthetic minority sampling technology (SMOTE) is proposed. First, aiming at the class imbalance, an improved SMOTE algorithm based on Mahalanobis distance (Mahalanobis distance‐based SMOTE [MSMOTE]) is proposed for oversampling. As the Euclidean distance in the traditional SMOTE algorithm does not consider the coupling relationship between features, the Mahalanobis distance is introduced, which is not dependent on the scale and eliminates the influence of different dimensions. Second, in order to better obtain the global and local information of the sample, the kernel local Fisher discriminant analysis (KLFDA) algorithm is used for feature extraction. Third, a multi‐fault diagnosis model based on the AdaBoost.M2 classifier is constructed in which the decision tree is introduced as the weak classifier. The Adaboost.M2 algorithm integrates multiple decision trees by setting the sample weight, the label weight, and the classifier weight, which effectively improve the classification accuracy by only using the decision tree. Finally, the Tennessee Eastman process is used to conduct case studies. For the comparison results, the proposed multi‐fault diagnosis method based on improved SMOTE has higher accuracy and F1‐Score.
Minimal/Measurable Disease Analysis in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma by Flow Cytometry
Authors: Gao Qi , Roshal Mikhail 
Published: August 2022

AbstractCLL/SLL is the most common leukemia in the western world. The disease is indolent; however, most patients require treatment at some point of the disease course. Outside of allogeneic transplants, the treatment is rarely curative but often controls CLL/SLL manifestations for many years. Several lines of therapy may be used sequentially to prolong clinical remission. Because of the prolonged disease course, CLL/SLL monitoring represents a sizable portion of the workload in a typical flow cytometry laboratory involved in the diagnosis and monitoring of hematopoietic neoplasms. Minimal/measurable disease monitoring of CLL/SLL has emerged as a key component in treatment monitoring and sequencing. In the face of effective therapies, clinical laboratories are tasked with monitoring ever smaller proportions of MRD with high precision and accuracy. With the recent addition of surface antigen–targeting biologics such as antibodies and CAR‐T cells, the task has become more complex due to the unavailability of commonly analyzed antigens for flow cytometric analysis. This article details a flow cytometric test developed at Memorial Sloan Kettering Cancer Center that has proven to consistently achieve high sensitivity (<0.01% of nucleated cells) in the bone marrow and peripheral blood, even when CD19 is lost or unavailable for analysis. Moreover, the test helps distinguish between CLL and other CD5‐positive B cell neoplasms. The Basic Protocol provides a detailed operational procedure for processing, staining, and cytometric acquisition of samples. The Support Protocol provides typical steps and caveats for MRD data analysis in CLL/SLL and in distinguishing CLL/SLL from other B cell neoplasms and normal CD5‐positive B cells. © 2022 Wiley Periodicals LLC.Basic Protocol: Processing, staining, and cytometric analysis of bone marrow or peripheral blood cells for MRD analysis of CLL/SLLSupport Protocol: Analysis and interpretation of CLL MRD assay
Dysregulated glucuronic acid metabolism exacerbates hepatocellular carcinoma progression and metastasis through the TGFβ signalling pathway
Authors: Gao Qingzhu , Cheng Bin , Chen Chang , Lei Chong , Lin Xue , Nie Dan , Li Jingjing , Huang Luyi , Li Xiaosong , Wang Kai , Huang Ailong , Tang Ni 
Published: August 2022

AbstractBackgroundGlucuronic acid metabolism participates in cellular detoxification, extracellular matrix remodeling and cell adhesion and migration. Here, we aimed to explore the crosstalk between dysregulated glucuronic acid metabolism and crucial metastatic signalling in glutathione S‐transferase zeta 1 (GSTZ1)‐deficient hepatocellular carcinoma (HCC).MethodsTranswell, HCC xenograft and Gstz1−/‐ mouse models were used to examine the role of GSTZ1 in HCC metastasis. Non‐targeted and targeted metabolomics and global transcriptomic analyses were performed to screen significantly altered metabolic and signalling pathways in GSTZ1 overexpressing hepatoma cells. Further, RNA‐binding protein immunoprecipitation, Biotin‐RNA pull‐down, mRNA decay assays and luciferase reporter assays were used to explore the interaction between RNA and RNA‐binding proteins.ResultsGSTZ1 was universally silenced in both human and murine HCC cells, and its deficiency contributed to HCC metastasis in vitro and in vivo. UDP‐glucose 6‐dehydrogenase (UGDH)‐mediated UDP‐glucuronic acid (UDP‐GlcUA) accumulation promoted hepatoma cell migration upon GSTZ1 loss. UDP‐GlcUA stabilized TGFβR1 mRNA by enhancing its binding to polypyrimidine tract binding protein 3, contributing to the activation of TGFβ/Smad signalling. UGDH or TGFβR1 blockade impaired HCC metastasis. In addition, UGDH up‐regulation and UDP‐GlcUA accumulation correlated with increased metastatic potential and decreased patient survival in GSTZ1‐deficient HCC.ConclusionsGSTZ1 deficiency and subsequent up‐regulation of the glucuronic acid metabolic pathway promotes HCC metastasis by increasing the stability of TGFβR1 mRNA and activating TGFβ/Smad signalling. UGDH and a key metabolite, UDP‐GlcUA, may serve as prognostic markers. Targeting UGDH might be a promising strategy for HCC therapy.
Documenting hip‐hop as a driving force
Authors: Elfman Lois 
Published: August 2022

Dr. Toby S. Jenkins describes her upcoming book, The Hip‐Hop Mindset, as another iteration of her professional work exploring the assets, strategies, and professional brilliance found within community cultures. The associate professor of higher education and interim associate dean for diversity, equity, and inclusion at The Graduate School, University of South Carolina, Jenkins has researched and written about how cultures teach strategies for success.
Development and usability testing of a chatbot to promote mental health services use among individuals with eating disorders following screening
Authors: Shah Jillian , DePietro Bianca , D'Adamo Laura , Firebaugh Marie‐Laure , Laing Olivia , Fowler Lauren A. , Smolar Lauren , Sadeh‐Sharvit Shiri , Taylor C. Barr , Wilfley Denise E. , Fitzsimmons‐Craft Ellen E. 
Published: August 2022

AbstractObjectiveA significant gap exists between those who need and those who receive care for eating disorders (EDs). Novel solutions are needed to encourage service use and address treatment barriers. This study developed and evaluated the usability of a chatbot designed for pairing with online ED screening. The tool aimed to promote mental health service utilization by improving motivation for treatment and self‐efficacy among individuals with EDs.MethodsA chatbot prototype, Alex, was designed using decision trees and theoretically‐informed components: psychoeducation, motivational interviewing, personalized recommendations, and repeated administration. Usability testing was conducted over four iterative cycles, with user feedback informing refinements to the next iteration. Post‐testing, participants (N= 21) completed the System Usability Scale (SUS), the Usefulness, Satisfaction, and Ease of Use Questionnaire (USE), and a semi‐structured interview.ResultsInterview feedback detailed chatbot aspects participants enjoyed and aspects necessitating improvement. Feedback converged on four themes: user experience, chatbot qualities, chatbot content, and ease of use. Following refinements, users described Alex as humanlike, supportive, and encouraging. Content was perceived as novel and personally relevant. USE scores across domains were generally above average (~5 out of 7), and SUS scores indicated “good” to “excellent” usability across cycles, with the final iteration receiving the highest average score.DiscussionOverall, participants generally reflected positively on interactions with Alex, including the initial version. Refinements between cycles further improved user experiences. This study provides preliminary evidence of the feasibility and acceptance of a chatbot designed to promote motivation for and use of services among individuals with EDs.Public SignificanceLow rates of service utilization and treatment have been observed among individuals following online eating disorder screening. Tools are needed, including scalable, digital options, that can be easily paired with screening, to improve motivation for addressing eating disorders and promote service utilization.
Fortress Europe 4.0? An analysis of EU data governance through the lens of the resource regime concept
Authors: König Pascal D. 
Published: August 2022

AbstractThis paper leverages the resource regime concept to systematically analyze the shape of data governance established by European Union (EU) digital policy. It highlights what gives shape and coherence to this data governance across different policies and how this governance structures relations between actors in the data economy. The analysis shows a common thrust in the EU's digital policies since its 2010 Digital Agenda. Overall, EU data governance is market‐creating not only through rules that directly aim at strengthening market integration and limiting anti‐competitive behavior but also through regulation that works to protect and promote EU‐based industries and to bolster their competitiveness in a global economy. EU digital policies complement each other in establishing more favorable conditions for EU businesses in relation to non‐EU competitors, and this market‐creating neo‐mercantilist orientation is rooted even in data and consumer protection policies that also have a market‐correcting dimension.
In the back of your mind: Cortical mapping of paraspinal afferent inputs
Authors: Cole David M. , Stämpfli Philipp , Gandia Robert , Schibli Louis , Gantner Sandro , Schuetz Philipp , Meier Michael L. 
Published: August 2022

AbstractTopographic organisation is a hallmark of vertebrate cortex architecture, characterised by ordered projections of the body's sensory surfaces onto brain systems. High‐resolution functional magnetic resonance imaging (fMRI) has proven itself as a valuable tool to investigate the cortical landscape and its (mal‐)adaptive plasticity with respect to various body part representations, in particular extremities such as the hand and fingers. Less is known, however, about the cortical representation of the human back. We therefore validated a novel, MRI‐compatible method of mapping cortical representations of sensory afferents of the back, using vibrotactile stimulation at varying frequencies and paraspinal locations, in conjunction with fMRI. We expected high‐frequency stimulation to be associated with differential neuronal activity in the primary somatosensory cortex (S1) compared with low‐frequency stimulation and that somatosensory representations would differ across the thoracolumbar axis. We found significant differences between neural representations of high‐frequency and low‐frequency stimulation and between representations of thoracic and lumbar paraspinal locations, in several bilateral S1 sub‐regions, and in regions of the primary motor cortex (M1). High‐frequency stimulation preferentially activated Brodmann Area (BA) regions BA3a and BA4p, whereas low‐frequency stimulation was more encoded in BA3b and BA4a. Moreover, we found clear topographic differences in S1 for representations of the upper and lower back during high‐frequency stimulation. We present the first neurobiological validation of a method for establishing detailed cortical maps of the human back, which might serve as a novel tool to evaluate the pathological significance of neuroplastic changes in clinical conditions such as chronic low back pain.
Body weight changes and duration of estrogen exposure modulate the evolution of hepatocellular adenomas after contraception discontinuation
Authors: Demory Alix , Péron Jean‐Marie , Calderaro Julien , Selves Janick , Mokrane Fatima‐Zohra , Amaddeo Giuliana , Paradis Valérie , Ziol Marianne , Sutter Olivier , Blaise Lorraine , Ganne‐Carrié Nathalie , Vilgrain Valérie , Cauchy François , Zucman‐Rossi Jessica , Ronot Maxime , Nault Jean‐Charles 
Published: August 2022

Background and Aims:
The natural history of hepatocellular adenomas (HCAs) remains to be better described, especially in nonresected patients. We aim to identify the predictive factors of HCA evolution after estrogen‐based contraception discontinuation.

Approach and Results:
We retrospectively included patients with a histological diagnosis of HCA from three centers. Clinical, radiological, and pathological data were collected to identify predictive factors of radiological evolution per Response Evaluation Criteria in Solid Tumors, version 1.1, and occurrence of complications (bleeding, malignant transformation). We built a score using variables that modulate estrogen levels: body mass index and duration of estrogen‐based contraception. An external cohort was used to validate this score. 183 patients were included in the cohort, including 161 women (89%) using estrogen‐based contraception for a median of 12 years. Thirty percent of patients had at least one HNF1A‐inactivated HCA, 45.5% at least one inflammatory HCA, and 11% at least one HCA with activation of β‐catenin (bHCA). Twenty‐one symptomatic bleedings (11%) and eleven malignant transformations (6%) occurred. Ages < 37 years old (p = 0.004) and HCA > 5 cm at imaging were independently associated with symptomatic bleeding (p = 0.003), whereas a bHCA was associated with malignant transformation (p < 0.001). After a median follow‐up of 5 years, radiological regression was observed in 31%, stabilization in 47%, and progression in 22% of patients. Weight loss was associated with regression (p < 0.0001) and weight gain with progression (p = 0.02). The estrogen exposure score predicted radiological regression (odds ratio, 2.33; confidence interval 95%, 1.29–4.19; p = 0.005) with a linear relationship between the rate of estrogen exposure and the probability of regression. This result was confirmed in an external cohort of 72 female patients (p = 0.003).

Conclusion
Weight variation is strongly associated with radiological evolution after oral contraception discontinuation. A score of estrogen exposure, easily assessable in clinical practice at diagnosis, predicts regression of HCA.
Demographic characteristics and anxiety in the educational setting during the COVID‐19 pandemic in Indonesia: A cross‐sectional study
Authors: Triastuti N. Juni , Herawati Erna 
Published: August 2022

AbstractBackground and AimsThis study aims to analyze the relationship between gender, age, occupation, residence, and anxiety in the education environment during the coronavirus disease 2019 (COVID‐19) pandemic.MethodsThis study used a descriptive‐analytic cross‐sectional design to determine anxiety using the DASS 42 questionnaire given to 181 respondents. The sampling technique used was purposive sampling, and the data analysis used was the Chi‐square test and multivariate analysis.ResultsIt was found that 66.7% of teenagers experienced anxiety, while 33.3% of adults experienced anxiety. In addition, the school‐age community (86.2%) experienced higher anxiety compared with the working‐age community (13.8%) who experienced anxiety. Women experienced more significant anxiety (66.7%) compared with men (33.3%). People living on the island of Java (74.7%) have a greater incidence of anxiety compared with people living outside Java (25.3%).ConclusionThere is a significant relationship between the type of occupation and the incidence of anxiety with p < 0.05 (OR = 0.341). A significant correlation was found between age with the incidence of anxiety with p < 0.05 (OR = 0.489). The demographic factors altogether had significant relationships with the anxiety in the educational environment during the COVID‐19 pandemic with a p value < 0.05 and R Square of 0.069. There is a strong relationship between the demographic factors and the incidence of anxiety in the community's educational environment during the COVID‐19 pandemic with p < 0.05. It is suggested that women, school‐age communities, or the un‐employment community need to be supported to alleviate the impact of COVID‐19 on anxiety through several programs.
Biomass‐based biomimetic‐oriented Janus nanoarchitecture for efficient heavy‐metal enrichment and interfacial solar water sanitation
Authors: Zhao Hao‐Yu , Dong Wei‐Xu , Deng Yu , Chen Li‐Feng , Zhao Chen‐Fan , Zhang Chuan‐Ling , Zhou Jie , Qu Yi‐Fan , Li Yan‐Song , Li Dong‐Jun , Yu Shu‐Hong 
Published: August 2022

AbstractInterfacial solar steam generation (ISSG), involving the use of solar energy to evaporate water at the water‐to‐vapor interface, has presented prospects for the desalination and purification of water due to high energy conversion efficiency and low‐cost freshwater generation. Herein, inspired by the aligned nanostructure of plants for efficiently transporting nutrient ions, we optimally design and construct a biomass‐based Janus architecture evaporator with an oriented nanostructure for ISSG, using the ice template method, followed by biomimetic mineralization with the resource‐abundant and low‐cost biomass of the carboxymethyl cellulose and sodium alginate as the raw materials. Taking advantage of the oriented nanostructure allowing efficient transportation of water and coordination capacity of sodium alginate for effective enrichment of heavy‐metal ions, the biomass‐based Janus architecture shows much lower thermal conductivity and an ultrahigh steam regeneration rate of 2.3 kg m−2 h−1, considerably surpassing those of previously reported oriented biomass‐based evaporators. Moreover, the biomass precursor materials are used for this Janus evaporator, guaranteeing minimum impact on the water ecology and environment during the regeneration process of clean drinking water. This study presents an efficient, green, and sustainable pathway for ISSG to effectively achieve heavy‐metal‐free drinking water.
Resistance to prostate cancer treatments
Authors: Krause Werner 
Published: August 2022

AbstractA review of the current treatment options for prostate cancer and the formation of resistance to these regimens has been compiled including primary, acquired, and cross‐resistance. The diversification of the pathways involved and the escape routes the tumor is utilizing have been addressed. Whereas early stages of tumor can be cured, there is no treatment available after a point of no return has been reached, leaving palliative treatment as the only option. The major reasons for this outcome are the heterogeneity of tumors, both inter‐ and intra‐individually and the nearly endless number of escape routes, which the tumor can select to overcome the effects of treatment. This means that more focus should be applied to the individualization of both diagnosis and therapy of prostate cancer. In addition to current treatment options, novel drugs and ongoing clinical trials have been addressed in this review.
Therapeutic plasma exchange practices in immune thrombocytopenia related hospitalizations: Results from a nationally representative sample
Authors: Makhani Sarah S. , Schwartz Joseph , Vasovic Ljiljana V. , DeSimone Robert A. , Kaicker Shipra , Bussel James , Crowe Elizabeth P. , Bloch Evan M. , Tobian Aaron A. R. , Goel Ruchika 
Published: August 2022

AbstractPer the American Society for Apheresis, therapeutic plasma exchange (TPE) is a Category III indication in the management of immune thrombocytopenia (ITP). This nationally representative study evaluates TPE utilization in hospitalized adults with a primary admission diagnosis of ITP. Hospitalizations with ITP as the primary admitting diagnosis were analyzed from the 2010 to 2014 National Inpatient Sample, the largest all‐payer inpatient database in the United States. Univariate and multivariable logistic regressions were used to determine clinical outcomes in ITP patients undergoing TPE. Sampling weights were applied to generate nationally representative estimates. From 2010 to 2014, there were a total of 56,149 admissions with a primary admitting diagnosis of ITP, of which 0.66% admissions (n = 372) also coded TPE. Most subjects undergoing TPE were the highest disease severity class: major (34.6%) and extreme severity (31.0%), by all‐patients refined diagnoses‐related groups severity of illness subclass. After multivariable analysis, underlying severity of illness remained the most significant predictor of TPE (P < .001). ITP admissions with TPE had a high rate of comorbidities (50%) and significantly longer mean length of hospital stay than those without (P < .001). TPE was reported in ~0.6% of hospitalizations with ITP as the primary diagnosis in this nationally representative sample from 2010 to 2014. TPE was performed in patients with the highest severity of underlying illness, and higher rates of comorbidities.
Superficial Parotidectomy for Juvenile Recurrent Parotitis
Authors: Wilson John , Gorelik Michael , Gulliver Jessica , Jaju Alok , Bhushan Bharat , Rastatter Jeffrey , Johnston Douglas , Maddalozzo John 
Published: August 2022

ObjectivesTo investigate long‐term outcomes, imaging, and pathologic findings in pediatric patients who underwent superficial parotidectomy for recalcitrant juvenile recurrent parotitis (JRP).MethodsRecords for 20 children (23 parotidectomies; 9 females, 11 males; age at surgery of 8.6 ± 3.7 years) collected over a 10‐year period (2012–2021) were reviewed. Parents were contacted via telephone to obtain extended follow‐up. A simplified scoring system was used to assess imaging findings and an additional pathologic review was conducted to further clarify the underlying disease process.ResultsAll but one patient experienced resolution of their recurrent symptoms after superficial parotidectomy. Three of the patients studied required surgery on the contralateral side, and this could be predicted based on their imaging at the time of the initial surgery. Pathologic findings included ductal fibrosis, metaplasia, and dilatation as well as parenchymal atrophy and fatty deposition. There were no major surgical complications, however, the incidence of Frey's syndrome in this sample was 43.5% of surgical sites.ConclusionFor patients with frequent recalcitrant symptoms or significant quality of life impairment related to JRP, superficial parotidectomy represents a potential treatment option with the noted reduction in symptom burden following surgery. Further longitudinal studies are needed.Level of Evidence4 Laryngoscope, 133:1495–1500, 2023