bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, attitude and perception towards COVID-19 among representative educated sub-Saharan Africans: A cross-sectional study during the exponential phase of the pandemic
Authors: Udoakang* Aniefiok , Nganyewo Nora Nghochuzie , Zune Alexandra Lindsey Djomkam , Olwal Charles Ochieng’ , Etim Nsikak-Abasi Aniefiok , Oboh Mary Aigbiremo , Tapela Kesego , Dzabeng Francis , Adadey Samuel Mawuli , Udoh Agnes , Koné Mazo , Mutungi* Joe Kimanthi , Quashie* Peter Kojo , Awandare Gordon Akanzuwine , Paemka* Lily 
Published: May 2022

Abstract
Coronavirus disease 2019 (COVID-19) pandemic, caused by the Severe Acute Coronavirus 2 (SARS-CoV-2), is a global health threat with extensive misinformation and conspiracy theories. Therefore, this study investigated the knowledge, attitude and perception of sub-Saharan Africans (SSA) on COVID-19 during the exponential phase of the pandemic. In this cross-sectional survey, self-administered web-based questionnaires were distributed through several online platforms. A total of 1046 respondents from 35 SSA countries completed the survey. The median age was 33 years (18–76 years) and about half (50.5%) of them were males. More than 40% across all socio-demographic categories except participants from the Central African region (21.2%), those with vocational/secondary education (28.6%), as well as student/unemployed (35.5%), had high COVID-19 knowledge scores. Socio-demographic factors and access to information were associated with COVID-19 knowledge. Bivariate analysis revealed that independent variables, including the region of origin, age, gender, education and occupation, were significantly (p < 0.05) associated with COVID-19 knowledge. Multivariate analysis showed that residing in East (odds ratio [OR]: 7.9, 95% confidence interval (CI): 4.7–14, p < 0.001), Southern (OR: 3.7, 95% CI: 2.1–6.5, p < 0.001) and West (OR: 3.9, 95% CI: 2.9–5.2, p < 0.001) Africa was associated with high COVID-19 knowledge level. Apart from East Africa (54.7%), willingness for vaccine acceptance across the other SSA regions was < 40%. About 52%, across all socio-demographic categories, were undecided. Knowledge level, region of origin, age, gender, marital status and religion were significantly (p < 0.05) associated with COVID-19 vaccine acceptance. About 67.4% were worried about contracting SARS-CoV-2, while 65.9% indicated they would consult a health professional if exposed. More than one-third of the respondents reported that their governments had taken prompt measures to tackle the pandemic. Despite high COVID-19 knowledge in our study population, most participants were still undecided regarding vaccination, which is critical in eliminating the pandemic. Therefore, extensive, accurate, dynamic and timely education in this aspect is of ultimate priority.
A large public dataset of annotated clinical MRIs of patients with acute stroke and linked metadata
Authors: Liu Chin-Fu , Leigh Richard , Johnson Brenda , Urrutia Victor , Hsu Johnny , Xu Xin , Li Xin , Mori Susumu , Hillis Argye , Faria Andreia 
Published: May 2022

Abstract
To extract meaningful and reproducible models of brain function from stroke images, for both clinical and research proposes, is a daunting task severely hindered by the great variability of lesion frequency and patterns. Large datasets are therefore imperative, as well as fully automated image post-processing tools to analyze them. The development of such tools, particularly with artificial intelligence, is highly dependent on the availability of large datasets to model training and testing. We present a public dataset of 2,888 multimodal clinical MRIs of patients with acute and early subacute stroke, with manual lesion segmentation, and metadata. The dataset provides high quality, large scale, human-supervised knowledge to feed artificial intelligence models and enable further development of tools to automate several tasks that currently rely on human labor, such as lesion segmentation, labeling, calculation of disease-relevant scores, and lesion-based studies relating function to frequency lesion maps
Impact of International Expansion Strategy on the Performance of Japanese Banks
Authors: A Joseph Jr. , Harimaya Kozo 
Published: May 2022

Abstract
The effect of cross-border diversification on bank performance is part of the broader debate on how multinational banking and financial integration affect the global financial economy. Much of the empirical studies examining this relationship present mixed results globally. Studies on both sides of the expansion spectrum find that cross-border diversification improves bank performance but also increases bank risks leading to systemic failure. Even so, this line of debate has not been examined in the case of Japanese ‘city banks’ conducting international operations. The present study questions whether cross-border diversification improves the performance of Japanese banks and to what extent each cross-border expansion activity affects bank performance. The latter was largely ignored in previous studies. The study finds that cross-border diversification, in general, improves cost efficiency but decreases/harms profit efficiency of the banks analysed. Precisely, diversification activities such as foreign assets and foreign branch expansion present funding risks and operational inefficiency. The study concludes that, as a regional player, the current trend in cross-border expansion activities of Japanese banks requires close monitoring and supervision to prevent episodes of regional financial crises. Moreover, the current cross-border diversification strategies of these banks, especially the expansion and operation of overseas branch networks (retail banking) need to be re-examined.
A meta-analysis of PCAT1; prostate cancer-associated transcript 1 gene as a prognostic biomarker for invasive breast carcinoma
Authors: Chakrabarty Brototi , Afrin Kashifa , Siraj Md Afjalus 
Published: May 2022

Abstract
Prostate cancer-associated transcript 1 (PCAT1) is a long non-coding RNA (lncRNA), composed of more than 200 nucleotides. Its expression controls the proliferation, migration, invasion, and metastasis of different cancer. In the current study, we conducted a patient data derived metanalysis to study the possible role of PCAT1 as a prognostic biomarker for the invasive breast cancer (IBC). Our analysis demonstrated that, PCAT1 highly expressed in BRCA mutated BC patients’ cells compared to normal cells (fold change ~ 1.56). The overall survival rate of patients with higher PCAT1 expression significantly (p- 5.539e− 5) reduced over time. Moreover, PCAT1 was significantly altered in PR (p- 1.672e-6), HER2 (p- 3.190e-6) negative and ER (p- 3.920e-4) positive primary IBC samples. In addition, alteration of PCAT1 also correlated with the histologic grade of the IBC (p- >10− 10). On top of that, we found co-occurrence of PCAT1 with the oncogenes of CASC family i.e., CASC8, CASC11, and CASC19 in IBC. The genomic location of PCAT1, CASC8, CASC11, and CASC19 was chr8q24 and chr8q24 respectively which contains the loci responsible for different cancers including BC. In addition, the CASC8 and CASC19 overlapped with PCAT1 in genomic sequence. Taken together, PCAT1 expression is associated with poor clinical outcomes and co-occur with previously established oncogenes and biomarkers which suggest its usefulness as a prognostic biomarker for IBC.
Nuclear movement generate binuclear cells during neural transdifferentiation from human bone marrow-derived mesenchymal cells
Authors: bueno Carlos , Blanquer Miguel , Bernal David García- , Martínez Salvador , Moraleda José M 
Published: May 2022

Abstract
Although it has been reported that bone marrow-derived mesenchymal stromal cells (BM-MSCs) can transdifferentiate into neural cells, the findings is considered unlikely. Cytotoxic-induced cell changes and cell fusion events are alternative explanations for these observations in culture and transplantation studies, respectively.Here, we show that BM-MSCs neural transdifferentiation involves a formation of dedifferentiated cells that can then redifferentiate into neural-like cells, redifferentiate back to mesenchymal fate, or even switch lineages repeatedly without cell division. Futhermore, we have discovered that nuclei from dedifferentiated cells move within the cell adopting different morphologies and even forming binucleated cells. In addition, we noted that dedifferentiated cells position their nucleus at the forefront of the cell during cell migration.Our result show that human BM-MSCs can rapidly adopt a neural-like morphology and binuclear human BM-MSCs can be formed without being related to cell fusion events. We provide additional evidences that BM-MSCs can transdifferentiate into neural cells.
Independent Correlation Between Ischemia Modified Albumin and Parathormone in End Stage Renal Disease
Authors: Güçlü Kenan , Tur Kağan , Şahin Serdar , Güçlü Aydın 
Published: May 2022

Abstract
Background
Oxidative stress (OS) has an important role at development of chronic kidney disease (CKD) and progression to end stage renal disease (ESRD). Hemodialysis (HD) patients are the group which oxidative stress is found more exacerbated. Ischemia modified albumin (IMA) is a new and sensitive marker for ischemia and oxidative stress. At current study we evaluated relation between IMA and biochemical parameters in ESRD patients.
Methods and Results
Thirty-four patients with ESRD on maintenance HD were included in the study. A fasting blood sample pre-HD and post-HD blood sample at the end of the dialysis session were taken from all of the patients. Serum IMA, complete blood count and routine biochemistry parameters were measured. There was a positive correlation between alkaline phosphatase (ALP) and IMA (r = 0,268, p < 0,05), CRP and IMA (r = 0,452, p = 0,007), PTH and IMA (r = 0,436, p = 0,010), There was a negative correlation between albumin and IMA (r=-0,338, p = 0,05). Multiple regression analysis was run to predict IMA levels from PTH, CRP and creatinine the model statistically significantly predicted relation p < 0,05, R = 0,506, out of four two variables added statistically significant to the prediction, PTH (p = 0,006), CRP (p = 0,029). In multiregression analysis, IMA was found to be associated with PTH and CRP independent of creatinine value.
Conclusion
In this study, we showed for the first time that PTH is associated with IMA in ESRD patients, independent of the level of renal function. IMA may play an important role in the pathogenesis of inflammation due to increased PTH in ESRD. Further studies are needed to further elucidate this issue.
Identification and Validation of Immune-Related Gene Prognostic Signature for breast cancer
Authors: Zhou Bing , Zhang Linyi , Wang Qinyu , Pu Changqin , Guo Sixuan , Lai Shuhui , Zhang Heming , Li Wenwei , Zhou Zhibing , Chen Yuexia , Zhou Yao , Zeng Liping 
Published: May 2022

Abstract
Background
Although the outcome of breast cancer patients has been improved by advances in early detection, diagnosis and treatment, prognostic assessment still faces challenges due to the heterogeneity of the disease. The accumulated data indicate that there is a clear correlation between the tumor immune microenvironment and clinical outcomes.
Methods
We screened prognostic immune-relevant gene pairs (IRGPs) via univariate Cox regression analysis in the Cancer Genome Atlas (TCGA) cohort. Then, TCGA cohort were further divided into a training set (n = 755) and internal validation sets (n = 320). Least absolute shrinkage and selection operator (LASSO) Cox regression analysis was used to constituted the IRGP prognostic signature in training set. And the IRGP prognostic signature was validated in the internal TCGA validation cohort and external validation cohorts GSE20685 (n = 327), GSE42568 (n = 104), and GSE20711 (n = 88) from Gene Expression Omnibus (GEO) database. We estimated the immune cell infiltration in tumor microenvironment via CIBERSORT and ESTIMATE. We used the TIDE algorithm and stemness indices to evaluate the potential of IRGP signature as an indicator of response to immunotherapy. We used gene set enrichment analysis (GSEA) to elucidate the biological functions of the IRGP prognostic signature.
Results
We generated a IRGP prognostic signature consisting of 16 IRGPs. Subsequently, the 16 IRGPs grouped breast cancer patients into high- and low-risk groups. Survival analysis indicated that the IRGP signature possessed an independent prognostic value. The low-IRGP group exhibited a higher level of immune cell infiltration, higher expression of immune checkpoint molecules, lower tumor stemness indices, and was much more sensitive to immunotherapy. The functional enrichment analysis indicated that low IRGP value was correlated with biological processes related to immune.
Conclusion
The 16-IRGP prognostic signature was developed to provide new insights for the identification of high-risk breast cancer and the evaluation of the possibility of immunotherapy in personalized breast cancer treatment.
Innovation and Practice of Music Education Path in Colleges and Universities Under the Popularization of 5g Network
Authors: Song Xi 
Published: May 2022

Abstract
The value of music education in society and culture cannot be overstated. For students with exceptional needs, music education plays a vital role. Student benefits from community-based arts education programmes range from social to academic. The issue is that music education, like other arts programmes, is frequently not taught in special education classrooms. We propose fifth-generation (5G)-based music education for cognitive computing for tailored behavioural intervention utilizing 5G in this article. Cognitive computing is a multidisciplinary sector of study that aims to develop computational designs and decision-making procedures depending on brain neurobiology, cognitive science, and psychology. Cognitive-behavioral techniques aim to change students' perceptions, alter their behaviour, and increase their pain control. Music and other cognitive therapies try to regulate the stress response by effectively mediating emotional responses. These objectives can be met by using behavioural treatments that influence the individual's affective response, which is influenced by prior experiences, prior knowledge, and emotions. The suggested system's performance is evaluated and compared to existing approaches.
Copper-Catalyzed N-Arylation of Indoles
Authors: Hisana Kalathingal Nasreen , Abdulla Cheriya Mukkolakkol Afsina , Anilkumar Gopinathan 
Published: May 2022

Abstract:Over the past decades, the N-arylation of indoles has gained an inevitable role in the fields of material science, pharmaceuticals, and agrochemical industries. They are the basic core skeleton of many natural products. Their synthesis by Ullmann-type C-N coupling reaction of indole derivatives with aryl halides through various catalytic protocols is well explored. Transition metal catalysis was the best method for synthesizing 1-aryl indoles, and copper catalysis is the leading among them. This review comprehends the recent developments in the copper-catalyzed C-N cross-coupling of indoles with aryl halides from 2010 to 2022.
Advances in the Synthesis of AmidesviaAlpha Oxygenation of Amines
Authors: Mandrekar Ketan S. , Kadam Hari K. , Tilve Anita , Tilve Santosh G. 
Published: May 2022

Abstract:Amides are universal in nature. Proteins are polymers (polyamides) whose units are connected by amide (peptide) linkages. Proteins perform innumerable functions in the body. Important synthetic polymers (technology products) like nylon are also polyamides. Hence, amide is an important functionality in chemistry and biology and consequently synthesis of it has remained a focused research area. Many methods are available for the synthesis of amides. The classical methods involve making amides from carboxylic acids and amines. The energy unfavourable direct reaction between an acid and an amine is turned in to favourable pathway using coupling reagents. Coupling agents like DCC, HOBt, PyBOP, etc are used. However these reagents generate lots of waste. There are also other selective methods which include Beckmann rearrangement, Schmidt reaction, Willgerodt-Kindler reaction, Passerini reaction and so on. Recently there is surge of revelations regarding alternate pathways to synthesize amides focussing into green or catalytic approaches. In this review we have covered several such alternate methods which use amines as the precursors. Oxidation and reduction are the back bone of synthetic organic transformations. Several elegant oxidizing agents have been developed for the oxidation of alcohols and olefins with selectivity in mind. However, many of these oxidizing agents have potential to oxidize amines to amides but they were not studied earlier as green chemistry was not in much focus then. With present focus on sustainability and green chemistry, scientists have embarked to synthesise amides in greener way. One such way is to get amides in a cleaner way is to oxidize amines to amides. Hence, in this review we have endeavoured to compile all such methods which have been used to make amides or have the potential for such transformation. Other than use of several oxidizing reagents, tandem oxidation amidation and other miscellaneous methods are included in this review. The reactions which give amides as by-products are also included as such reactions are potential methods to synthesize amides. Mechanisms are also included at relevant places. The review is classified within the report available for the Oxidations of amines using transition metals, transition metal salts and transition metal oxides; Oxidations of amines using non-metals; Photocatalytic oxidations of amines; Air oxidation of amines; Electrochemical oxidations; Enzymatic conversions; Oxidative coupling of Aldehydes; Oxidative coupling of Alcohols; Oxidative amidation of Methylbenzenes; and Oxidation of aromatic nitrogen heterocycles.
Construction of PARPi Resistance-related Competing Endogenous RNA
Network
Authors: Xiang Juanjuan , Kong Lili , Xu Jiaqi , Yu Lijun , Liu Shuo , Liu Zongjian 
Published: May 2022

Objective:
Ovarian cancer is the common gynecological malignancy in women. PARP inhibitors (PARPi) have been approved for ovarian cancer treatment. However, the primary and acquired resistance have limited the application of PARPi. The mechanisms underlying remain to be elucidated.

Methods:
In this study, we characterized the expression profiles of mRNA and nonconding RNAs (ncRNAs) and constructed the regulatory networks based on RNA sequencing in PARPi Olaparib-induced ovarian cancer cells.

Results:
We found that the functions of the differentially expressed genes were enriched in “PI3K/AKT signaling pathway”“MAPK signaling pathway” and “metabolic process”. The functions of DELs (cis) were enriched in “Human papillomavirus infection”“tight junction” “MAPK signaling pathway”. As the central regulator of ceRNAs, the differentially expressed miRNAs were enriched in “Human papillomavirus infection” “MAPK signaling pathway” “Ras signaling pathway” . According to the degree of interaction, we identified 3 lncRNAs, 2 circRNAs, 7 miRNAs and 12 mRNA as the key regulatory ceRNA axis, in which miR-320b was the important mediator.

Conclusion:
Here, we revealed the key regulatory lncRNA (circRNA)-miRNA-mRNA axis and their involved pathways in the PARPi resistant ovarian cancer cells. These findings provide new insights in exploring the ceRNA regulatory networks and developing new targets for PARPi resistance.
HDAC Inhibitors against SARS-CoV-2
Authors: Omidkhah Negar , Hadizadeh Farzin , Ghodsi Razieh 
Published: May 2022

Abstract:
Following the coronavirus outbreak, global efforts to find a vaccine and drug affecting Covid-
19 have been widespread. Reusing some of the available drugs has had relatively satisfactory results. One
of the classes of drugs studied against SARS-CoV-2 is the HDAC inhibitors collected in this review.
Among the most important points of this study can be mentioned: (a) SARS-COV-2 infection can influence
the ACE/ACE2-ATR1-Cholesterol-HDAC axis signaling, (b) By limiting endocytosis and decreasing
ACE2-spike protein recognition at the same time, Romidepsin may hinder SARS-2-S-driven host cell
entry. (c) HDAC inhibitors affect the expression of ABO, ACE2 and TMPRSS2 in epithelial cell lines.
(d) Valproic acid may help to reduce ARDS as well as hospitalizations and death. (e) Trichostatin A inhibits
antigen expression, viral RNA load and infectious particle production in SARS-CoV-2.
Various Carbonic Anhydrases in Physiopathological Events, Carbonic
Anhydrase Inhibitors, and Hybrid Compounds
Authors: Er Ayse 
Published: May 2022

Abstract:
Enzymes are highly specific catalysts that accelerate reactions in biological systems. Carbonic
anhydrase (CA) is an enzyme found in plants, microorganisms, and vertebrates. CA catalyses CO2 hydration/
dehydration. There are different families and isoenzymes of CAs. Fifteen α-CA isoenzymes have
been reported in humans. The status of CO2 hydration and dehydration is important for a variety of biological
processes. CAs play an important role in many physiological and pathological events in several
tissue types. Their levels are increased in some diseases; therefore, CA inhibition has been applied as a
therapeutic option. However, the high diversity of these isoenzymes is an important consideration. Isoenzyme-
specific CA inhibitors can reduce the side effects of treatment. Some agents containing additional
sulfonamides approved for other therapeutic applications, such as topiramate, celecoxib/valdecoxib, sulpiride,
and famotidine, have inhibitory effects on CA isoenzymes. These bind to the zinc ion in the CA
active site. Recently, research has been conducted on the use of a hybrid form of active ingredient and a
CA inhibitor. CA inhibitor-NSAID hybrid compounds demonstrated more efficacy than NSAIDs in arthritis,
which has attracted further attention of researchers in conducting research on CA-hybrid drugs.
COVID-19 Associated Acute Pancreatitis: A Case Series from India
Authors: Singh Jitendra , Kumar Nilesh , Kumar Kailash , Dinkar Anju 
Published: May 2022

Introduction:
Initially, COVID-19 was typically concerned with respiratory symptoms and
had a mild and asymptomatic to critical clinical course. Over time, many atypical presentations related
to cardiac, hepatic, gastrointestinal, renal, musculoskeletal, and neurological features have been reported
in COVID-19.

Case Presentation:
We present three confirmed cases of COVID-19, who developed acute pancreatitis
without any other obvious discernible cause. One middle-aged 48-years old male was presented with
severe abdominal pain with mild symptoms of COVID-19, who was later diagnosed with acute pancreatitis
with a positive outcome. Another 40-year-old male, hospitalized due to moderate COVID-19,
developed acute pancreatitis and was managed successfully. The third 58-year-old patient with control
diabetes and severe COVID-19 developed acute necrotizing pancreatitis. Unfortunately, he succumbed
due to multiorgan failure while on the mechanical ventilator.

Conclusion:
Acute pancreatitis is uncommon in COVID-19. Although, it should be kept as a highindex
clinical suspicion if abdominal pain is reported. Early diagnosis and prompt management can
significantly impact the patient's outcome.