bluuebunny/crossref_metadata_2025_split huggingface dataset:
Street‐level traffic flow and context sensing analysis through semantic integration of multisource geospatial data
Authors: Zhang Yatao , Raubal Martin 
Published: November 2022

AbstractSensing urban spaces from multisource geospatial data is vital to understanding the transportation system in the urban context. However, the complexity of urban context and its indirect interaction with traffic flow deepen the difficulty of exploring their relationship. This study proposes a geo‐semantic framework first to generate semantic representations of multi‐hierarchical urban context and street‐level traffic flow, and then investigate their mutual correlation and predictability using a novel semantic matching method. The results demonstrate that each street is associated with its multi‐hierarchical spatial signatures of urban context and street‐level temporal signatures of traffic flow. The correlation between urban context and traffic flow displays higher values after semantic matching than those in multi‐hierarchies. Moreover, we found that utilizing traffic flow to predict urban context results in better accuracy than the reversed prediction. The results of signature analysis and relationship exploration can contribute to a deeper understanding of context‐aware transportation research.
Mutation of phytochrome B promotes resistance to sheath blight and saline–alkaline stress via increasing ammonium uptake in rice
Authors: Jung Jin Hee , Li Zhuo , Chen Huan , Yang Shuo , Li Dandan , Priatama Ryza A , Kumar Vikranth , Xuan Yuan Hu 
Published: November 2022

SUMMARYPhytochrome B (PhyB), a red‐light receptor, plays important roles in diverse biological processes in plants; however, its function in NH4+ uptake and stress responses of plants is unclear. Here, we observed that mutation in indeterminate domain 10 (IDD10), which encodes a key transcription factor in NH4+ signaling, led to NH4+‐sensitive root growth in light but not in the dark. Genetic combinations of idd10 and phy mutants demonstrated that phyB, but not phyA or phyC, suppressed NH4+‐sensitive root growth of idd10. PhyB mutants and PhyB overexpressors (PhyB OXs) accumulated more and less NH4+, respectively, compared with wild‐type plants. Real time quantitative polymerase chain reaction (RT‐qPCR) revealed that PhyB negatively regulated NH4+‐mediated induction of Ammonium transporter 1;2 (AMT1;2). AMT1 RNAi plants with suppressed AMT1;1, AMT1;2, and AMT1;3 expression exhibited shorter primary roots under NH4+ conditions. This suggested that NH4+ uptake might be positively associated with root growth. Further, PhyB interacted with and inhibited IDD10 and brassinazole‐resistant 1 (BZR1). IDD10 interacted with BZR1 to activate AMT1;2. NH4+ uptake is known to promote resistance of rice (Oryza sativa) to sheath blight (ShB) and saline–alkaline stress. Inoculation of Rhizoctonia solani demonstrated that PhyB and IDD10 negatively regulated and AMT1 and BZR1 positively regulated resistance of rice to ShB. In addition, PhyB negatively regulated and IDD10 and AMT1 positively regulated resistance of rice to saline–alkaline stress. This suggested that PhyB–IDD10–AMT1;2 signaling regulates the saline–alkaline response, whereas the PhyB–BZR1–AMT1;2 pathway modulates ShB resistance. Collectively, these data prove that mutation in the PhyB gene enhances the resistance of rice to ShB and saline–alkaline stress by increasing NH4+ uptake.
Models of English for research publication purposes
Authors: Flowerdew John 
Published: November 2022

AbstractEnglish for Research Publication Purposes (ERPP) is a sub‐field of English for Academic Purposes (EAP), itself a sub‐field of applied linguistics. This article considers ERPP from a world Englishes perspective, considering the question as to what sort of English is appropriate for ERPP: the standardised model, as preferred at present, or a varietal, world Englishes, model, which would take more account of the fact that the majority of scholars publishing their work in English are no longer Anglophones, but use English as an additional language (EAL). The article is in two parts. In the first part, the case for ‘Standard English’ is presented, while the second part presents the case for a varietal model. In spite of some limited evidence of world Englishes encroaching into international journals, the latter remain fundamentally conservative and anchored in Standard English. Factors which might increase the use of world Englishes are outlined.
Hot Pursuit
Authors: Langston Lee S. 
Published: November 2022

Abstract
Fueling gas turbines with hydrogen was a path not taken by early innovators. And for good reasons: Hydrogen atoms are so reactive that very little molecular hydrogen is available. Hydrocarbon fuels, such as methane, kerosene, and gasoline, became the energy source of choice for the technology. But the need to reduce carbon emissions has revived interest in hydrogen fuel.
Feasibility, safety and tolerability of the CREB-binding protein/β-catenin inhibitor OP-724 in patients with advanced primary biliary cholangitis: an investigator-initiated, open-label, non-randomised, two-centre, phase 1 study
Authors: Kimura Masamichi , Ogawa Eiichi , Harada Kenichi , Imamura Jun , Saio Masanao , Ikura Yoshihiro , Yatsuhashi Hiroshi , Murata Kazumoto , Miura Kouichi , Ieiri Ichiro , Tanaka Atsushi , Kimura Kiminori 
Published: November 2022

ObjectiveThis study aimed to evaluate the safety and tolerability of OP-724, a CREB-binding protein/β-catenin inhibitor, in patients with advanced primary biliary cholangitis (PBC).DesignAn open-label, non-randomised, phase 1 trial was conducted at two hospitals in Japan. Patients with advanced PBC classified as stage III or higher according to the Scheuer classification by liver biopsy between 4 September 2019 and 21 September 2021 were enrolled. Seven patients received intravenous OP-724 infusions at escalating dosages of 280 and 380 mg/m2/4 hours two times weekly for 12 weeks. The primary endpoint was the incidence of serious adverse events (SAEs). The secondary endpoints were the incidence of AEs and the improvement in the modified Histological Activity Index (mHAI) score.ResultsSeven patients (median age, 68 years) were enrolled. Of these seven patients, five completed twelve cycles of treatment, one discontinued prematurely for personal reasons in the 280 mg/m2/4 hours cohort, and one in the 380 mg/m2/4 hours cohort was withdrawn from the study due to drug-induced liver injury (grade 2). Consequently, the recommended dosage was determined to be 280 mg/m2/4 hours. SAEs did not occur. The most common AEs were abdominal discomfort (29%) and abnormal hepatic function (43%). OP-724 treatment was associated with histological improvements in the fibrosis stage (2/5 (40%)) and mHAI score (3/5 (60%)) on histological analysis.ConclusionAdministration of intravenous OP-724 infusion at a dosage of 280 mg/m2/4 hours two times weekly for 12 weeks was well tolerated by patients with advanced PBC. However, further evaluation of antifibrotic effects in patients with PBC is warranted.Trial registration numberNCT04047160.
Patient-derived Siglec-6-targeting antibodies engineered for T-cell recruitment have potential therapeutic utility in chronic lymphocytic leukemia
Authors: Cyr Matthew G , Mhibik Maissa , Qi Junpeng , Peng Haiyong , Chang Jing , Gaglione Erika M , Eik David , Herrick John , Venables Thomas , Novick Scott J , Courouble Valentine V , Griffin Patrick R , Wiestner Adrian , Rader Christoph 
Published: November 2022

BackgroundDespite numerous therapeutic options, safe and curative therapy is unavailable for most patients with chronic lymphocytic leukemia (CLL). A drawback of current therapies such as the anti-CD20 monoclonal antibody (mAb) rituximab is the elimination of all healthy B cells, resulting in impaired humoral immunity. We previously reported the identification of a patient-derived, CLL-binding mAb, JML-1, and identified sialic acid-binding immunoglobulin-like lectin-6 (Siglec-6) as the target of JML-1. Although little is known about Siglec-6, it appears to be an attractive target for cancer immunotherapy due to its absence on most healthy cells and tissues.MethodsWe used a target-specific approach to mine for additional patient-derived anti-Siglec-6 mAbs. To assess the therapeutic utility of targeting Siglec-6 in the context of CLL, T cell-recruiting bispecific antibodies (T-biAbs) that bind to Siglec-6 and CD3 were engineered into single-chain variable fragment–Fc and dual-affinity retargeting (DART)–Fc constructs. T-biAbs were evaluated for their activity in vitro, ex vivo, and in vivo.ResultsWe discovered the anti-Siglec-6 mAbs RC-1 and RC-2, which bind with higher affinity than JML-1 yet maintain similar specificity. Both JML-1 and RC-1 T-biAbs were effective at activating T cells and killing Siglec-6+target cells. The RC-1 clone in the DART–Fc format was the most potent T-biAb tested and was the only anti-Siglec-6 T-biAb that eliminated Siglec-6+primary CLL cells via autologous T cells at pathological T-to-CLL cell ratios. Tested at healthy T-to-B cell ratios, it also eliminated a Siglec-6+fraction of primary B cells from healthy donors. The subpicomolar potency of the DART–Fc format was attributed to the reduction in the length and flexibility of the cytolytic synapse. Furthermore, the RC-1 T-biAb was effective at clearing MEC1 CLL cells in vivo and demonstrated a circulatory half-life of over 7 days.ConclusionSiglec-6-targeting T-biAbs are highly potent and specific for eliminating Siglec-6+leukemic and healthy B cells while sparing Siglec-6−healthy B cells, suggesting a unique treatment strategy for CLL with diminished suppression of humoral immunity. Our data corroborate reports that T-biAb efficacy is dependent on synapse geometry and reveal that synapse architecture can be tuned via antibody engineering. Our fully human anti-Siglec-6 antibodies and T-biAbs have potential for cancer immunotherapy.Trial registration numberNCT00923507.
NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload
Authors: Higashikuni Yasutomi , Liu Wenhao , Numata Genri , Tanaka Kimie , Fukuda Daiju , Tanaka Yu , Hirata Yoichiro , Imamura Teruhiko , Takimoto Eiki , Komuro Issei , Sata Masataka 
Published: November 2022

Background:
Mechanical stress on the heart, such as high blood pressure, initiates inflammation and causes hypertrophic heart disease. However, the regulatory mechanism of inflammation and its role in the stressed heart remain unclear. IL-1β (interleukin-1β) is a proinflammatory cytokine that causes cardiac hypertrophy and heart failure. Here, we show that neural signals activate the NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3) inflammasome for IL-1β production to induce adaptive hypertrophy in the stressed heart.

Methods:

C57BL/6 mice, knockout mouse strains for NLRP3 and P2RX7 (P2X purinoceptor 7), and adrenergic neuron-specific knockout mice for SLC17A9, a secretory vesicle protein responsible for the storage and release of ATP, were used for analysis. Pressure overload was induced by transverse aortic constriction. Various animal models were used, including pharmacological treatment with apyrase, lipopolysaccharide, 2′(3′)-
O
-(4-benzoylbenzoyl)-ATP, MCC950, anti–IL-1β antibodies, clonidine, pseudoephedrine, isoproterenol, and bisoprolol, left stellate ganglionectomy, and ablation of cardiac afferent nerves with capsaicin. Cardiac function and morphology, gene expression, myocardial IL-1β and caspase-1 activity, and extracellular ATP level were assessed. In vitro experiments were performed using primary cardiomyocytes and fibroblasts from rat neonates and human microvascular endothelial cell line. Cell surface area and proliferation were assessed.

Results:
Genetic disruption of NLRP3 resulted in significant loss of IL-1β production, cardiac hypertrophy, and contractile function during pressure overload. A bone marrow transplantation experiment revealed an essential role of NLRP3 in cardiac nonimmune cells in myocardial IL-1β production and cardiac phenotype. Pharmacological depletion of extracellular ATP or genetic disruption of the P2X7 receptor suppressed myocardial NLRP3 inflammasome activity during pressure overload, indicating an important role of ATP/P2X7 axis in cardiac inflammation and hypertrophy. Extracellular ATP induced hypertrophic changes of cardiac cells in an NLRP3- and IL-1β–dependent manner in vitro. Manipulation of the sympathetic nervous system suggested sympathetic efferent nerves as the main source of extracellular ATP. Depletion of ATP release from sympathetic efferent nerves, ablation of cardiac afferent nerves, or a lipophilic β-blocker reduced cardiac extracellular ATP level, and inhibited NLRP3 inflammasome activation, IL-1β production, and adaptive cardiac hypertrophy during pressure overload.

Conclusions:
Cardiac inflammation and hypertrophy are regulated by heart-brain interaction. Controlling neural signals might be important for the treatment of hypertensive heart disease.
Le manomissioni del ius civile e il momento acquisitivo della cittadinanza romana
Authors: Gagliardi Lorenzo 
Published: November 2022

Summary
A comparison is made among the three manumissions of the ius civile and it is investigated what was the moment in which the freedmen acquired Roman citizenship and could begin to exercise political rights. It is concluded that the manumissi censu acquired all political rights immediately after the manumission. The manumissi vindicta and testamento, on the other hand, acquired citizenship at the time of manumission, but had to wait for the census both to be admitted to the centuriate assembly and to be registered in the tribes (and therefore to receive the right to vote in the tribal assemblies).
Jacob Coren’s Observatio 40: shipowner liability for inculpable ship collision and its limitation in Roman-Dutch law
Authors: Lubbers Tim 
Published: November 2022

Summary
In 1617, two Dutch merchantmen collided in a storm on the North Sea. The incident resulted in extensive legal proceedings before the Supreme Court of Holland, Zeeland and West-Friesland, lasting until 1640. In an unprecedented decision, which was published as no. 40 of Jacob Coren’s well-known Observationes, the Court limited the liability of shipowners for inculpable ship collision to the value of their ship. Based both on extensive archival research and the text of Coren’s Observatio, the present article offers a detailed discussion of the facts and proceedings of the case, and sets out how the case was received by Roman-Dutch scholars. As it turns out, limitation of shipowner liability was analysed in terms of noxal surrender in order to reconcile shipowner liability for inculpable ship collision with contemporary perceptions of equity.
The Shaping of the 1857 Security Pact in the Regency of Tunis: A Reappraisal of the Nineteenth Century Constitutional Reforms
Authors: Zeghal Malika 
Published: November 2022

Abstract
This article examines the creation of the 1857 Security Pact (ʿAhd al-amān) in the Regency of Tunis. This law is commonly viewed as having been drafted and imposed by the European powers as a replication of the Ottoman Tanẓīmāt and as having inaugurated an era of modernizing reforms that led to a secularized nation-state, notably due to the notions of equality it introduced. I show instead that this new law aimed to solve concrete problems in a context of severe fiscal crisis and that its creation was more a story of hard-fought diplomatic negotiations than of modernization and secularization. While the Security Pact was imposed by European pressures, and while the Ottoman Tanẓīmāt were invoked during the negotiations, Tunisian political elites shaped its content from the start, in an effort to defend the beylical state’s legal sovereignty and affirm its Muslim character. It was these elites who introduced, against the wishes of the French government, equality for all inhabitants of the Regency (including foreigners) and the principle of a common jurisdiction for the bey’s subjects and for foreigners. These legal changes must not be analyzed as an exceptional rupture (a claim made by those who view the nineteenth century reforms as having initiated a “modern” Tunisia) but as part of a long series of transformations. Although not everyone agreed about their legitimacy, these transformations were understood by reformers within the framework of a long-standing Islamic theory of the practice of change that was based, not on ijtihād, but on the widening of custom (ʿurf) and of the discretionary power of the ruler (siyāsa).
The Bible in the Bowls
Authors: Waller Daniel James 
Published: November 2022

The Bible in the Bowls represents a complete catalogue of Hebrew Bible quotations found in the published corpus of Jewish Babylonian Aramaic magic bowls. As our only direct epigraphic witnesses to the Hebrew Bible from late antique Babylonia, the bowls are uniquely placed to contribute to research on the (oral) transmission of the biblical text in late antiquity; the pre-Masoretic Babylonian vocalisation tradition; the formation of the liturgy and the early development of the Jewish prayer book; the social locations of biblical knowledge in late antique Babylonia and socio-religious typologies of the bowls; and the dynamics of scriptural citation in ancient Jewish magic. In a number of cases, the bowls also contain the earliest attestations of biblical verses not found in the Dead Sea Scrolls. Pre-dating the next available evidence by four to five centuries, the bowls are a valuable resource for biblical text critics.
By making these valuable witnesses to the Hebrew Bible easily available to scholars, The Bible in the Bowls is designed to facilitate further research by linguists, liturgists, biblical text critics, and students of Jewish magic. It collates and transcribes each biblical verse as it appears in the published bowls, furnishes details of the bowls’ publication, and notes various features of interest. The catalogue is also accompanied by an accessible introduction that briefly introduces the incantation bowls, surveys their deployment of scripture in light of their magical goals, and discusses the orthography of the quotations and what this can tell us about the encounter with the biblical text in late antique Babylonia.
Use of fulvic acid-like compounds from pulp-derived black liquor for enhancing the selenium content of peanut buds
Authors: Ding Feng , Wei Xiaofeng , Dao Yuanren , Zhao Fei , Wang Ruiming , Li Piwu 
Published: November 2022

Abstract
Background
Cleaner production involving the extraction of useful material from the black liquor by-product of straw pulp would be environmentally beneficial and would permit increased wastewater usage.

Results
The fulvic-acid-like components of pulp black liquor (PFA) with molecular weights below 10 kDa were isolated. The chemical and physiological characteristics of PFAs were investigated. Selenite can enhance the selenium nutrition level of crops, but excessive selenite may be toxic to plant growth. In order to explore how to increase selenite tolerance and selenium accumulation in peanut, the effects of PFA on selenium-associated properties in peanut seedlings were examined by growing seedlings with sodium selenite (0, 5, 15, and 25 mg·L− 1 Na2SeO3, 15 mg·L− 1 Na2SeO3 solution containing 60 mg-C/L PFA, and 25 mg·L− 1 Na2SeO3 containing 60 mg-C/L PFA).

Conclusion
The results showed that with 15 mg·L− 1 Na2SeO3, PFA significantly increased both the total and hypocotyl fresh weight of the seedlings but reduced the fresh weight of the root. PFA also effectively promoted the conversion of Se from inorganic to organic compounds in the root and hypocotyl, increased the soluble total sugar and soluble protein contents of the hypocotyl, and thus improved the edible quality and food safety of the selenium-enriched peanut buds. The results suggest that PFA can be used as an innovative bio-based substance for selenium-enriched sprout vegetable production.
Systematic analysis of Histidine photosphoto transfer gene family in cotton and functional characterization in response to salt and around tolerance
Authors: Zhao Lanjie , Sun Liangqing , Guo Lixue , Lu Xuke , Malik Waqar Afzal , Chen Xiugui , Wang Delong , Wang Junjuan , Wang Shuai , Chen Chao , Nie Taili , Ye Wuwei 
Published: November 2022

AbstractBackgroundPhosphorylation regulated by the two-component system (TCS) is a very important approach signal transduction in most of living organisms. Histidine phosphotransfer (HP) is one of the important members of the TCS system. Members of theHPgene family have implications in plant stresses tolerance and have been deeply studied in several crops. However, upland cotton is still lacking with complete systematic examination of theHPgene family.ResultsA total of 103HPgene family members were identified. Multiple sequence alignment and phylogeny of HPs distributed them into 7 clades that contain the highly conserved amino acid residue “XHQXKGSSXS”, similar to theArabidopsisHP protein. Gene duplication relationship showed the expansion ofHPgene family being subjected with whole-genome duplication (WGD) in cotton. Varying expression profiles of HPs illustrates their multiple roles under altering environments particularly the abiotic stresses. Analysis is of transcriptome data signifies the important roles played by HP genes against abiotic stresses. Moreover, protein regulatory network analysis and VIGS mediated functional approaches of twoHPgenes (GhHP23andGhHP27) supports their predictor roles in salt and drought stress tolerance.ConclusionsThis study provides new bases for systematic examination ofHPgenes in upland cotton, which formulated the genetic makeup for their future survey and examination of their potential use in cotton production.