bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real‐world effectiveness of repeated ketamine infusions for treatment‐resistant bipolar depression
Authors: Fancy Farhan , Rodrigues Nelson B. , Di Vincenzo Joshua D. , Chau Edmond H. , Sethi Rickinder , Husain Muhammad I. , Gill Hartej , Tabassum Aniqa , Mckenzie Andrea , Phan Lee , McIntyre Roger S. , Rosenblat Joshua D. 
Published: December 2022

AbstractBackgroundClinical trials have demonstrated rapid antidepressant effects with intravenous (IV) ketamine for major depressive disorder, with relatively less research specifically for bipolar depression. Herein, we describe the real‐world effectiveness of repeated ketamine infusions for treatment‐resistant bipolar depression.MethodsThis study was conducted in a community clinic in Mississauga, Ontario (Canadian Rapid Treatment Centre of Excellence; Braxia Health). In this observational study (NCT04209296), patients with treatment‐resistant bipolar I/II depression (n = 66) received four sub‐anesthetic doses of IV ketamine (0.5–0.75 mg/kg) over a two‐week period. Symptoms of depression, suicidality, anxiety, and functioning were assessed with validated self‐report measures.ResultsStatistically and clinically significant antidepressant effects were observed in the overall sample, as measured by the Quick Inventory for Depression Symptomatology‐Self Report‐16 (QIDS‐SR16) with further reductions in depressive symptoms observed after each subsequent infusion (n = 66; mean QIDS‐SR16 reduction of 6.08+/−1.39; p < 0.0001). Significant reductions of suicidal thoughts (QIDS‐SR16‐Suicide Item) and anxiety (Generalized Anxiety Disorder‐7) were also observed with functional improvements on the Sheehan Disability Scale (p < 0.0001 on all measures). Moreover, the response rate (QIDS‐SR16 total score decrease ≥50% from baseline) was 35% and remission rate (QIDS‐SR16 total score ≤5) was 20% after four infusions. Infusions were generally well tolerated with treatment‐emergent hypomania observed in only three patients (4.5%) with zero cases of mania or psychosis.ConclusionsReal‐world effectiveness of IV ketamine for bipolar depression was observed. Repeated doses were associated with greater symptom reduction and adequate tolerability.
Survival of patients with mantle cell lymphoma in the rituximab era: Retrospective binational analysis between 2000 and 2020
Authors: Harmanen Minna , Hujo Mika , Sund Reijo , Sorigue Marc , Khan Madiha , Prusila Roosa , Klaavuniemi Tuula , Kari Esa , Jantunen Esa , Sunela Kaisa , Rajamäki Aino , Alanne Erika , Kuitunen Hanne , Sancho Juan‐Manuel , Jukkola Arja , Rönkä Aino , Kuittinen Outi 
Published: December 2022

SummaryMantle cell lymphoma (MCL) is a rare peripheral B‐cell lymphoma characterised by eventual relapse and progression towards a more aggressive disease biology. With the introduction of rituximab‐ and cytarabine‐based immunochemotherapy regimens, the prognosis of the disease has changed dramatically over the last two decades. To assess the real‐world survival of patients with MCL, we used a population‐based cohort of 564 patients with MCL who were diagnosed and treated between 2000 and 2020. Patient data were collected from seven Finnish treatment centres and one Spanish treatment centre. For the entire patient population, we report a 2‐year overall survival (OS) rate of 77%, a 5‐year OS of 58%, and a 10‐year OS of 32%. The estimated median OS was 80 months after diagnosis. MCL is associated with increased mortality across the entire patient population. Additionally, we assessed the survival of patients after MCL relapse with the aim of establishing a cut‐off point of prognostic significance. Based on our statistical analysis of survival after the first relapse, disease progression within 24 months of the initial diagnosis should be considered as a strong indicator of poor prognosis.
Phenotypes of adults with Fanconi anaemia
Authors: Wang YunZu Michele , Loveless Michaela , Miller Erica , Nelson Adam S. , Mehta Parinda A. , Davies Stella M. , Myers Kasiani C. 
Published: December 2022

SummaryThe long‐term outcomes of adults with Fanconi anaemia (FA) have improved with advances in haematopoietic stem cell transplantation (HSCT) and more detailed follow‐up and screening guidelines. The phenotype of those who survive to adulthood may differ from the typical presentation of FA. We collected retrospective clinical data on adults with FA who received their care at the Cincinnati Children's Hospital Medical Center. In our final cohort of 52 patients, there were 29 females and 23 males, with median (range) age of 21 (18–37) years. Overall, 42 patients (81%) were alive at last follow‐up. In all, 36 adults (69%) had undergone HSCT, including eight who had developed myelodysplasia or acute myeloid leukaemia. Eight (15%) developed squamous cell carcinoma. Endocrine complications were common, including hypothyroidism (42%), diabetes (10%), low body mass index (31%) and low bone mineral density (51%). The majority of adults with FA were employed (52%) or full‐time students (13%). A significant subset of patients with FA are surviving into adulthood without requiring HSCT. Endocrine abnormalities and the development of solid tumours complicate adulthood. With improved survival outcomes following HSCT and more aggressive malignancy screening protocols, ongoing longitudinal analysis will be important to further characterise this cohort and the phenotype of untransplanted adults with FA.
Meta‐analysis of the long‐term stratigraphic evolution of rifted margin basins: The GeoDyNamical Analysis approach applied to the South Atlantic Ocean
Authors: Laspatzis Sophie , Rouby Delphine , Rohais Sébastien , Nardin Élise 
Published: December 2022

AbstractModels of the formation of rifted margins have significantly evolved over the last decades by identifying new styles of crustal thinning and magmatic production. However, the expression of these different processes in the depositional environments of the overlying basins remains to be determined. Using only published data, we integrated the sedimentary evolution of 21 basins of the Equatorial, Central and South segments of the South Atlantic that record various styles of crustal thinning and magmatic production. To compare these basins that underwent rifting at different times, we developed a new type of analysis allowing to evaluate statistically the (dis)similarities in depositional environment trends by normalizing them to the tectonic phases of the basin (syn‐rift, transition and post‐rift) rather than the stratigraphic or absolute ages: The GeoDyNamical Analysis. We show that the timing of the long‐term retrograding mega‐sequence driven by lithosphere thinning depends on the deformation style and magma production. Along oblique margins of the Equatorial Segment, deepening initiated during syn‐rift because their narrow crustal thinning style favours rapid tectonic subsidence surpassing sediment supply. Along wide margins of the Central Segment, deepening is initiated later, at the end of the transition phase, because depth‐dependent thinning favours slow tectonic subsidence and late break‐up. Along magma‐rich margins of the South Segment, deepening is initiated during the transition phase, after volcanics stopped filling accommodation created by subsidence. In the Central Segment, evaporites accumulated during the second half of the transition phase, when crustal thinning ceased in the proximal margin and migrated to its distal part. Immediately before and during evaporites accumulation, sediments recorded continental and coastal depositional environments resulting from the limited thermal subsidence in the proximal margin domain. Evaporite deposition lasted until the initiation of retrograding mega‐sequence, at the onset of the post‐rift phase and the end of crustal thinning in the distal margin.
Cyberbullying among adolescents in Turkey: the relationship between coping strategies and cyberbullying perpetration
Authors: Erbiçer Eyüp Sabır , Toprak Emre , Metin Ahmet 
Published: December 2022

BackgroundCyberbullying is becoming a global threat with the ease of access to the internet. Although many studies addressed the relationship between coping strategies and cyber victimization, the role of coping strategies, protective or risk factors, on involvement in cyberbullying perpetration is unclear. Therefore, the present study aims to examine the effect of active, avoidant, and negative coping strategies and the sociodemographic variables (i.e., parents' education, gender, and family income) on cyberbullying perpetration behaviors.MethodThe study was conducted on 1032 adolescents (mean age = 16.01 years; range = 14–18 years), 608 (58.9%) were female, and 424 (41.1%) were male. Personal Information Form, Cyberbullying Scale, and Coping Scale for Adolescents (the KIDCOPE) were used in data collection. Multiple regression analysis was performed for data analysis.ResultsThe study's findings revealed that active coping strategy (β = −.26, p < .001) was a protective factor for cyberbullying perpetration behaviors, whereas avoidant (β = .31, p < .001) and negative coping (β = .32, p < .001) strategies and the mother's education (β = .10, p < .001) were risk factors. However, the study results showed that gender (β = −.01, p > .05), family income (β = .03, p > .05), and the father's education (β = .01, p > .05) were not predicting factors of cyberbullying perpetration behaviors.ConclusionsThe results are discussed in light of the relevant literature and presented some theoretical and practical implications.
Adrenal incidentaloma: Do patients with apparently nonfunctioning mass or autonomous cortisol secretion have similar or different clinical and metabolic features?
Authors: Rebelo João Felipe Dickson , Costa Julia Magarão , Junqueira Fernanda Damasceno , Fonseca Adelmo de Oliveira , de Almeida Ana Beatriz Alcantara Bérenger Samarcos , Moraes Aline Barbosa , Vieira Neto Leonardo 
Published: December 2022

AbstractObjectiveAlthough there is growing evidence associating nonfunctioning adrenal incidentalomas (NFAI) with cardiovascular risk factors, there are limited data whether NFAI and autonomous cortisol secretion (ACS) groups have similar or different clinical and metabolic features. The aim of this study is to compare cardiometabolic clinic parameters among patients with ACS and NFAI, as well as controls.DesignCross‐sectional study.PatientsEighty nine NFAI, 58 ACS and 64 controls were evaluated.MeasurementsDiagnosis of NFAI (1 mg dexamethasone suppression test [1 mg‐DST] ≤50 nmol/L [≤1.8 μg/dl]) and ACS (1 mg‐DST > 50 nmol/L [> 1.8 μg/dl]) was established according to current guidelines. The control group was selected based on a normal adrenal imaging exam.ResultsThere were no differences between groups regarding age, gender, ethnicity, menopause or body mass index. Patients with adrenal incidentaloma presented higher frequency of hypertension (74.1 vs. 57.8%; p = .02), resistant hypertension (45.4 vs. 9.4%; p < .001), dyslipidemia (80.1 vs. 63.9%; p = .01), as well as metabolic syndrome (84.2 vs. 61.7%; p = .001) compared to the controls, respectively. NFAI and ACS patients presented similar frequency of arterial hypertension (70.8 vs. 79.3%) and resistant hypertension (41.3 vs. 51.1%), dyslipidemia (79.3 vs. 81.5%) and metabolic syndrome (83.3 vs. 85.7%); also, levels of HbA1c were similar between the groups. Binary logistic regression showed that NFAI (p = .004) and ACS (p = .001) were independent predictors for resistant hypertension (p = .003); also, ACS was an independent predictor for metabolic syndrome (p = .04).ConclusionsNFAI and ACS presented a higher frequency of cardiometabolic morbidities in comparison with individuals with normal adrenal glands. Additionally, we demonstrated that both ACS and NFAI groups have similar cardiometabolic conditions.
Variants in BRWD3 associated with X‐linked partial epilepsy without intellectual disability
Authors: Tian Mao‐Qiang , Liu Xiao‐Rong , Lin Si‐Mei , Wang Jie , Luo Sheng , Gao Liang‐Di , Chen Xiao‐Bin , Liang Xiao‐Yu , Liu Zhi‐Gang , He Na , Yi Yong‐Hong , Liao Wei‐Ping ,   For the China Epilepsy Gene 1.0 Project
Published: December 2022

AbstractAimsEtiology of the majority patients with idiopathic partial epilepsy (IPE) remains elusive. We thus screened the potential disease‐associated variants in the patients with IPE.MethodsTrios‐based whole exome sequencing was performed in a cohort of 320 patients with IPE. Frequency and molecular effects of variants were predicted.ResultsThree novel BRWD3 variants were identified in five unrelated cases with IPE, which were four male cases and one female case. The variants included two recurrent missense variants (c.836C>T/p.Thr279Ile and c.4234A>C/p.Ile1412Leu) and one intronic variant close to splice site (c.2475 + 6A>G). The two missense variants were located in WD40 repeat domain and bromodomain, respectively. They were predicted to be damaging by silico tools and change hydrogen bonds with surrounding amino acids. The frequency of mutant alleles in this cohort was significantly higher than that in the controls of East Asian and all population of gnomAD. All these variants were inherited from the asymptomatic mothers. Four male cases presented frequent seizures at onset, while the female case only had two fever‐triggered seizures. They showed good responses to valproate and lamotrigine, then finally became seizure free. All the cases had no intellectual disability. Further analysis demonstrated that all previously reported destructive variants of BRWD3 caused intellectual disability, while missense variants located in WD40 repeat domains and bromodomains of BRWD3 were associated with epilepsy.ConclusionBRWD3 gene is potentially associated with X‐linked partial epilepsy without intellectual disability. The genotypes and locations of BRWD3 variants may explain for their phenotypic variation.
Salinity appears to be the main factor shaping spatialCOIdiversity of Corbicula lineages within the Chinese Yangtze River Basin
Authors: Zeng Cong , Tang Yangxin , Vastrade Martin , Coughlan Neil E. , Zhang Ting , Cai Yongjiu , Van Doninck Karine , Li Deliang 
Published: December 2022

AbstractAimTo date, few studies have examined the phylogenetics of Corbicula clams in their native range and the environmental parameters influencing their distribution, although this could provide great insights into the biological adaptation and invasion dynamics of Corbicula clams. We sought to identify the genetic lineages of native Corbicula clams and elucidate the environmental factors shaping the distributions of identified lineages.LocationChina, mainly the Yangtze River Basin.MethodsThe alignment comprised 558COIsequences including samples from China and 222COIsequences from published studies. This dataset was used to generate phylogenetic trees and compare population diversity. We used dbRDA method to assess the relationship between theseCOIdata and environmental factors measured to identify the important factors affecting Corbicula's distribution.ResultsTheCOIphylogenetic tree delineated the monophyly of 3 majorCOIclades and 77 distinctCOIhaplotypes in the Yangtze River Basin. The invasive lineage C/S (FW17) was not identified in our sampling in China, while invasive lineages A/R (FW5 = Hap6), B (FW1 = Hap17) and Rlc (FW4 = Hap43) were identified, abundant and widely distributed in the middle and lower reaches of Yangtze River. Focusing on populations from Yangtze River Basin, both theCOIhaplotype and nucleotide diversity in the lakes along the Yangtze River increased with longitude, except for the river mouth population. The AMOVA tests showed significant differentiation between the middle and lower reaches of the Yangtze River and among populations. The dbRDA results suggested that the parameter chloride explained most of the spatialCOIhaplotype distribution variation in the Yangtze River Basin, with the three invasive lineages tolerating broad fluctuations of salinity (chloride levels ranging from 4 to 60 mg/L).ConclusionsThe CorbiculaCOIhaplotypes found within the Yangtze River Basin had distinct distribution preferences, with the invasive androgenetic lineages being the most abundant and widely distributed. Genetic diversity was higher in this native region than in invaded areas in Europe and America, while it decreased with increasing distance from the river mouth. Salinity appeared to be the main environmental factor shaping theCOIhaplotype distribution of Corbicula lineages within their native range.
HippocampalRNAsequencing in mice selectively bred for high and low activity
Authors: Booher Winona C. , Vanderlinden Lauren A. , Hall Lucy A. , Thomas Aimee L. , Evans Luke M. , Saba Laura M. , Ehringer Marissa A. 
Published: December 2022

AbstractHigh and Low Activity strains of mice were bidirectionally selected for differences in open‐field activity (DeFries et al., 1978, Behavior Genetics, 8: 3–13) and subsequently inbred to use as a genetic model for studying anxiety‐like behaviors (Booher et al., 2021, Genes, Brain and Behavior, 20: e12730). Hippocampal RNA‐sequencing of the High and Low Activity mice identified 3901 differentially expressed protein‐coding genes, with both sex‐dependent and sex‐independent effects. Functional enrichment analysis (PANTHER) highlighted 15 gene ontology terms, which allowed us to create a narrow list of 264 top candidate genes. Of the top candidate genes, 46 encoded four Complexes (I, II, IV and V) and two electron carriers (cytochrome c and ubiquinone) of the mitochondrial oxidative phosphorylation process. The most striking results were in the female high anxiety, Low Activity mice, where 39/46 genes relating to oxidative phosphorylation were upregulated. In addition, comparison of our top candidate genes with two previously curated High and Low Activity gene lists highlight 24 overlapping genes, whereNdufa13, which encodes the supernumerary subunit A13 of complex I, was the only gene to be included in all three lists. Mitochondrial dysfunction has recently been implicated as both a cause and effect of anxiety‐related disorders and thus should be further explored as a possible novel pharmaceutical treatment for anxiety disorders.
Remote control? Chinese satellite infrastructure in and above the Arctic global commons
Authors: Bennett Mia M. , Eiterjord Trym 
Published: December 2022

AbstractChina is expanding its Arctic presence by developing infrastructure in the global commons that intersect with the region. Operations in outer space, the deep sea and cyberspace minimise the need for terrestrial footholds and generate data, a virtual resource. To analyse the epistemic and geopolitical consequences of developing the Arctic global commons as a vertically and digitally integrated volume, we examine a critical form of Chinese ‘remote infrastructure’: optical, synthetic aperture radar, and navigation satellites. We argue that first, by generating data about the Arctic, these instruments turn China into a regional knowledge producer. Second, as remote observations outnumber field observations, Chinese polar science may shift the regional balance of knowledge towards spaceborne and marine observations. Third, China's emergence as an Arctic knowledge producer may motivate the state to contribute to regional governance as remote sensing and large‐scale, computationally intensive techniques become privileged decision‐making tools. To transcend the terrestrial and maritime fixes that predominate research on China and the Arctic, we call for greater attention to the influence of epistemic capacities on geopolitics.
Depression and anxiety in persons with Von Willebrand disease
Authors: Roberts Jonathan C. , Kulkarni Roshni , Kouides Peter A. , Sidonio Robert F. , Carpenter Shannon L. , Konkle Barbara A. , Wu Joanne , Ullman Megan M. , Curtis Randall , Baker Judith R. , Crook Nicole , Nichol Michael B. 
Published: December 2022

AbstractObjectiveWe assessed sociodemographic and clinical characteristics associated with depression and anxiety in individuals with Von Willebrand disease (VWD) aged ≥12 years.MethodsThe study collected data on patients’ sociodemographic, joint problems and health‐related quality of life (HRQoL) using EQ‐5D‐3L, 8‐item patient health questionnaire for depression and 7‐item Generalized Anxiety Disorder Questionnaire from participants in seven geographically diverse US haemophilia treatment centres.ResultsAnalyses included 77 participants. The rates of depression and anxiety were 63.6% and 58.3%, respectively. Persons with low VWF displayed higher rates of depression (86.7%) or anxiety (69.2%) compared to those with VWD (58.1%, p = .04 for depression, and 55.9%, p = .38 for anxiety). Logistic regression analyses demonstrated that having joint problems (odds ratio [OR] = 6.3, confidence interval [CI] = 2.0–20.1) was the most important variable associated with depression, followed by being single, divorced, widowed, or separated in adult participants or parents of participants age < 18 years (OR = 7.0, CI = 1.7–29.0. The most important variable associated with anxiety was being single or lacking a partner (OR = 10.8, CI = 2.5–47.5), followed by age 12–17 years old (OR = 6.7, CI = 1.6–26.9), or having worse health compared to 3‐months ago (OR = 12.3, CI = 1.3‐116.2). Mean covariates adjusted EQ visual analogue scale score was significantly lower among persons with depression (68.77 ± 3.15 vs. 77.58 ± 4.24, p = .03) than those without depression.ConclusionsOur study revealed concerning levels of depression and anxiety in this VWD sample. Lack of social support was determined an important factor associated with depression and anxiety in this sample. Mental health screening is critical in VWD clinical evaluation and care.
Harnessing the potential of trace data and linguistic analysis to predict learner performance in a multi‐text writing task
Authors: Raković Mladen , Iqbal Sehrish , Li Tongguang , Fan Yizhou , Singh Shaveen , Surendrannair Surya , Kilgour Jonathan , van der Graaf Joep , Lim Lyn , Molenaar Inge , Bannert Maria , Moore Johanna , Gašević Dragan 
Published: December 2022

AbstractBackgroundAssignments that involve writing based on several texts are challenging to many learners. Formative feedback supporting learners in these tasks should be informed by the characteristics of evolving written product and by the characteristics of learning processes learners enacted while developing the product. However, formative feedback in writing tasks based on multiple texts has almost exclusively focused on essay product and rarely included SRL processes.ObjectivesWe explored the viability of using product and process features to develop machine learning classifiers that identify low‐ and high‐performing essays in a multi‐text writing task.MethodsWe examined learning processes and essay submissions of 163 graduate students working on an authentic multi‐text writing assignment. We utilised learners' trace data to obtain process features and state‐of‐the‐art natural language processing methods to obtain product features for our classifiers.Results and ConclusionsOf four popular classifiers examined in this study, Random Forest achieved the best performance (accuracy = 0.80 and recall = 0.77). The analysis of important features identified in the Random Forest classification model revealed one product (coverage of reading topics) and three process (elaboration/organisation, re‐reading and planning) features as important predictors of writing quality.Major TakeawaysThe classifier can be used as a part of a future automated writing evaluation system that will support at scale formative assessment in writing tasks based on multiple texts in different courses. Based on important predictors of essay performance, a guidance can be tailored to learners at the outset of a multi‐text writing task to help them do well in the task.