bluuebunny/crossref_metadata_2025_split huggingface dataset:
Placental and Umbilical Cord Blood Oxidative Stress Level and
Telomere Homeostasis in Early Onset Severe Preeclampsia
Authors: Baser Emre , Inandiklioglu Nihal , Aydogan Kırmızı Demet , Ercan Fedi , Caniklioğlu Ayşen , Kara Mustafa , Onat Taylan , Yalvac Ethem Serdar 
Published: October 2022

Abstract
Objective Although the etiopathogenesis of preeclampsia (PE) is unknown,
evidence suggests that it may be associated with increased oxidative stress.
Studies have shown that oxidative stress can affect DNA fragments called
telomeres. However, the interactions of PE, oxidative stress, and telomere
length are not clearly known. This study aims to evaluate the
oxidative/anti-oxidative stress balance in the placenta and umbilical
cord and examine the effect of oxidative stress on telomeres.
Materials-Method Cord blood and placental samples were collected from 27
pregnant women with severe PE
(280/7–336/7 gestational
weeks) and 53 healthy pregnant women. Telomere length (TL) was measured by
real-time PCR in the cord blood and placenta tissue. Total antioxidant status
(TAS) and total oxidant status (TOS) levels were measured in the cord blood and
placenta tissue using a colorimetric method.
Results No significant differences were found between groups regarding
age, BMI, gravida, parity, and newborn gender (p>0.05). Cord blood and
placental TL of PE patients were significantly shorter than the control group,
while cord blood and placental TAS and TOS levels were higher (p<0.05).
The results of a multivariate logistic regression analysis showed that the level
of placental TOS in PE patients (OR=1.212, 95%
CI=1.068–1.375) was an independent risk factor affecting PE.
Conclusion This study found that oxidative stress is an independent risk
factor in the development of PE and shortens TL in both placental and umbilical
cord blood. Future research on telomere homeostasis may offer a new perspective
for the treatment of PE.
Adipocyte-Derived Exosomal LINC00968 Promotes Mouse Retina Microvascular Endothelial Cell Dysfunction in a High-Glucose Environment by Modulating the miR-361–5p/TRAF3 Axis
Authors: He Wenjing , Lin Anhua , Wang Chenxiu 
Published: October 2022

AbstractAs a major cause of mortality, cardiovascular disease is associated with obesity and diabetes. However, the molecular mechanism by which diabetes-obesity causes cardiovascular complications is largely unknown. In this study, the crosstalk mediated by 3T3-L1 preadipocytes and mouse retina microvascular endothelial cells (mRMECs) was determined after co-culturing performed with a Transwell system or measuring exosome uptake by mRMECs. CCK-8 assays, EdU incorporation assays, TUNEL staining, and ELISAs were used to evaluate the functions of mRMECs. Related protein markers were analyzed by western blotting. Our results showed that LINC00968 levels were significantly elevated in the exosomes derived from H-Glu-induced 3T3-L1 preadipocytes. Both H-Glu treatment and co-culture with 3T3-L1 cells damaged mRMECs, as indicated by lower rates of proliferation and higher rates of apoptosis and cell adhesion molecule expression, as well as by induced inflammation and oxidative stress, which were enhanced by combined H-Glu and co-culture treatment. Furthermore, H-Glu and co-culture treatment increased LINC00968 expression in mRMECs, and the exosomes collected from 3T3-L1 cells had a similar effect. Functionally, LINC00968 inhibition protected mRMECs against the effects of H-Glu and co-culture treatment, while LINC00968 played the opposite role. LINC00968 was found to target miR-361–5p, and TRAF3 was identified as a target gene of miR-361–5p. Finally, miR-361–5p overexpression alleviated the effects of LINC00968 on H-Glu-induced mRMEC dysfunction in vitro. In conclusion, our results indicated that in an H-glu environment, adipocyte exosomes damage microvascular endothelial cells via a LINC00968/miR-361–5p/TRAF3 signaling pathway, which could possibly serve as a target for treating diabetes-obesity-triggered microvascular complications.
Preventive Approaches in Women's Neurology: Prepartum, Pregnancy, and Postpartum
Authors: Kirkpatrick Laura , Waters Janet , O'Neal Mary Angela 
Published: October 2022

AbstractWomen's neurology is the subspecialty within neurology concerned with the distinct healthcare needs of women. In this article, we review current literature and expert management strategies regarding disease-specific neurologic concerns of women, with an emphasis on issues related to contraception, pregnancy, and lactation. Health conditions that we discuss in this article include epilepsy, headache, stroke, multiple sclerosis, and Chiari I malformation. Current findings on neurologic disease in women suggest that many women with neurologic disease can safely manage their disease during pregnancy and have healthy children, though pregnancy planning is important in many conditions to mitigate risks and effective contraceptive management is important when pregnancy prevention is desired.
Long-Term Effects of Antiseizure Medications
Authors: LoPinto-Khoury Carla 
Published: October 2022

AbstractMost patients with epilepsy will benefit from seizure control with one of an array of chronic antiseizure medications. Knowledge of the potential long-term effects of these medications is critical to prevent adverse consequences on overall health. Antiseizure medications vary in their capacities to affect the brain and peripheral nerves, hormones, bone mineralization, cardiovascular risk, renal health, hepatic, hematological, and dermatological systems. Understanding of pathophysiology and population risk has evolved, although most of the data available are still on older generation antiseizure medications such as phenytoin, carbamazepine, and valproic acid. The enzyme-inducing properties of some antiseizure medications make their effects on cardiovascular risk and bone health detrimental. Few clear guidelines exist for monitoring long-term effects of medication therapy for epilepsy. When selecting an antiseizure medication, consideration should be given to the individual patient's risks of adverse consequences on other organ systems. During monitoring of patients on chronic therapy, screening tools such as metabolic panels and bone density measurements can help stratify risk and guide management.
Endoscopic sphincterotomy vs papillary large balloon dilation vs combination modalities for large common bile duct stones: a network meta-analysis
Authors: Aziz Muhammad , Khan Zubair , Haghbin Hossein , Kamal Faisal , Sharma Sachit , Lee-Smith Wade , Pervez Asad , Alastal Yaseen , Nawras Ali , Thosani Nirav 
Published: October 2022

Abstract
Background and study aims The optimal technique for removal of large common bile duct (CBD) stones (≥ 10 mm) during endoscopic retrograde cholangiopancreatography (ERCP) remains unclear. We aimed to perform a comparative analysis between different endoscopic techniques.
Methods Adhering to PRISMA guidelines, a stringent search of the following databases through January 12, 2021, were undertaken: PubMed/Medline, Embase, Web of Science, and Cochrane. Randomized controlled trials comparing the following endoscopic techniques were included: (1) Endoscopic sphincterotomy (EST); (2) Endoscopic papillary large balloon dilation (EPLBD); and (3) EST plus large balloon dilation (ESLBD). Stone clearance rate (SCR) on index ERCP was the primary outcome/endpoint. Need for mechanical lithotripsy (ML) and adverse events were also evaluated as secondary endpoint. Random effects model and frequentist approach were used for statistical analysis.
Results A total of 16 studies with 2545 patients (1009 in EST group, 588 in EPLBD group, and 948 patients in ESLBD group) were included. The SCR was significantly higher in ESLBD compared to EST risk ratio [RR]: 1.11, [confidence interval] CI: 1.00–1.24). Lower need for ML was noted for ESLBD (RR: 0.48, CI: 0.31–0.74) and EPLBD (RR: 0.58, CI: 0.34–0.98) compared to EST. All other outcomes including bleeding, perforation, post-ERCP pancreatitis, stone recurrence, cholecystitis, cholangitis, and mortality did not show significant difference between the three groups. Based on network ranking, ESLBD was superior in terms of SCR as well as lower need for ML and adverse events (AEs).
Conclusions Based on network meta-analysis, ESLBD seems to be superior with higher SCR and lower need for ML and AEs for large CBD stones.
Subxiphoid Mediastinoscopic Autonomous Double Fenestration
Authors: Nistor Claudiu-Eduard , Cucu Anca Pati , Gavan Camelia , Ciuche Adrian 
Published: October 2022

AbstractThe coexistence of pleural and pericardial effusions in frail patients with or without confirmed neoplasia necessitates the use of a minimally invasive technique that has a minor impact on the patient's general status and allows for fast fluid evacuation and biopsy sampling if necessary. We present a subxiphoid mediastinoscopic autonomous (simultaneous noncommunicating) double fenestration approach for these patients with both diagnostic and therapeutic advantages in selected cases. Using the mediastinoscope alone through the subxiphoid incision can considerably reduce the duration of operation, allow for fluid evacuation, and significantly alleviate the patient's symptoms. This method enables the sampling of pleural and pericardial fluids and targeted tissue, if necessary.
Preliminary Experience of Extracorporeal Cytokine Hemoadsorption during Left Ventricular Assist Device Implantation in Cardiogenic Shock Patients
Authors: Pausch Jonas , Mersmann Julian , Bhadra Oliver D. , Barten Markus J. , Alassar Yousuf Al , Schulte-Uentrop Leonie , Reichenspurner Hermann , Bernhardt Alexander M. 
Published: October 2022

Abstract
Background Systemic inflammation due to cardiogenic shock is associated with vasoplegia leading to organ hypoperfusion, right heart failure, and poor clinical outcome. Extracorporeal cytokine hemoadsorption emerged to attenuate excessive levels of inflammatory cytokines, potentially improving patient outcomes. Nevertheless, its prognostic impact during high-risk left ventricular assist device (LVAD) implantation remains unknown.
Methods In total, 40 consecutive patients with advanced heart failure underwent continuous-flow LVAD implantation at our institution between 2018 and 2020. Out of 25 high-risk patients in cardiogenic shock (Interagency Registry for Mechanically Assisted Circulatory Support profile 1 and 2), 9 patients (CytoSorb group) underwent LVAD implantation with and 16 patients (control group) without simultaneous cytokine hemoadsorption during cardiopulmonary bypass. Besides preoperative patient characteristics, postoperative lactate clearance, vasopressor administration and mean arterial pressure, perioperative complication, and 30-day mortality rates were retrospectively analyzed.
Results Apart from an increased rate of reoperations within the CytoSorb group, baseline characteristics including the severity of ventricular dysfunction and consecutive signs of end-organ failure were similar in both groups. Preoperative short-term mechanical circulatory support bridging was comparable (66.7 vs. 75%; p = 0.66) prior to LVAD implantation. Procedural characteristics including intraoperative volume management and postoperative vasopressor administration were similar in both groups. There was no difference regarding postoperative lactate clearance, although postoperative mean arterial pressure was significantly higher in the control group (71.3 vs. 57.4 mm Hg; p < 0.01). Furthermore, the 30-day mortality rate was significantly higher in the CytoSorb group (33.3 vs. 0.0%; p = 0.01).
Conclusion Extracorporeal cytokine hemoadsorption during high-risk LVAD implantation was not associated with a decrease of postoperative vasopressor support, improved hemodynamics, or an accelerated lactate clearance.
Coloanal Anastomosis
Authors: Johnston William Forrest 
Published: October 2022

AbstractThe furthest extent of restorative proctectomy involves a colon to anal anastomosis in the deep pelvis. While the anastomosis can be challenging, it can allow the patient to avoid a permanent ostomy. Patient and surgeon preparation can improve patient outcomes. This article will describe the options, technical challenges, and anecdotal tips for coloanal anastomosis.
Proximalization of Frozen Elephant Trunk Procedure: Zone 0 or 1 versus Zone 2 or 3 Arch Repair
Authors: Lee Kwok Fai Lucius , Bhatia Inderjeet , Chan Tai Leung Daniel , Au Wing Kuk Timmy , Ho Ka Lai Cally 
Published: October 2022

Abstract
Background Total arch replacement with the frozen elephant trunk (FET) procedure has changed the landscape of therapy for aortic arch diseases. The optimal landing zone for a FET is controversial. We sought to share our early and midterm results of the FET procedure as well as compare the clinical outcomes of proximal and distal FET anastomosis.
Methods A total of 100 patients who underwent total arch replacement using the FET technique were identified between November 2014 and August 2021. According to the FET anastomosis over the aortic arch, patients were classified into two groups (zone 0/1 vs. zone 2/3). In-hospital mortality, complications, and midterm outcomes were assessed based on patient characteristics.
Results The overall in-hospital mortality was 8%. Major complications occurred in 32% of patients, including spinal cord injury (5%), stroke (7%), and acute kidney injury requiring dialysis (7%). Zone 2/3 FET (odds ratio: 6.491, 95% confidence interval: 1.930–21.835, p = 0.003) was an independent predictor of the composite endpoint of major complications. The rate of complete false lumen thrombosis was comparable (64.3% vs. 71.4%, p = 0.567). All patients, patients with zone 0/1 FET, and patients with zone 2/3 FET had 3-year freedom from aorta-related events of 73.0, 70.2, and 75.0%, respectively. There were no significant differences (log-rank test, p = 0.500).
Conclusion Compared with zone 2/3, proximalization of FET using zone 0/1 for anastomosis was associated with better early outcomes and comparable rates of midterm aorta-related events. To substantiate its use, more research on this approach is required.
Examining the association between health status and subjective life expectancy among older Indian adults based on the mindsponge approach
Authors: Kumar Manish , Srivastava Shobhit , Muhammad T. , Saravanakumar Priya 
Published: October 2022

AbstractGender and socioeconomic differences in subjective life expectancy (SLE) are an unexplored arena in the geriatric literature concerning low-resource settings. Information on several health outcomes that might influence the SLE could guide targeted interventions, particularly in countries with rapidly ageing populations like India. This study aimed to explore SLE and the associations of SLE with the objective and subjective health status of older Indian adults, based on the mindsponge mechanism that links the contextual factors with individuals' evaluation of health. Data from the Longitudinal Ageing Study in India were used and the final sample included 5969 older adults aged 60 years and above. Independentt-tests were used to assess the gender difference in SLE according to various health-related factors. Additionally, we used generalized linear regression models (GLMs) with a logit link and a binomial family to fulfil the study objectives. The proportion of older adults who reported a 100% probability of survival for a 1-year period was nearly 38%, compared with 12% and 6% of the respondents who reported the same for 5 and 10 years survival periods, respectively. Older men reported a greater average probability of own survival than older women for all the time periods. Older men who reported poor self-rated health had a significantly lower SLE for a 1-year period (β = −0.232, SD = 0.107) and a 5-year period (β = −0.226, SD = 0.077) than those who reported good self-rated health. On the other hand, older women with poor self-rated health had a significantly lower SLE for a 10 years time horizon than women with good self-rated health. Underweight men had significantly lower SLE for a 1-year period than men with normal BMI (β = −0.213, SD = 0.097). Further, cognitively impaired women reported significantly lower SLE for a 1-year period (β = −0.399, SD = 0.108) and 5 years period (β = −0.160, SD = 0.077). Depressed older men reported significantly lower SLE for 1-year period (β = −0.309, SD = 0.101), 5-year period (β = −0.194, SD = 0.084), and 10-year period (β = −0.129, SD = 0.071). The current findings, supporting the mindsponge mechanism, indicate that older adults base their estimation of longevity on health factors that they are aware of or not. This finding has significant implications for health professionals and public policy in planning targeted interventions that can benefit at-risk population cohorts.
Characteristics of the cylindrical reflex triode driven by a four-stage linear transformer driver
Authors: Lai Dingguo , Xu Qifu , Qiu Mengtong , Sun Fengju , Jiang Xiaofeng , Li Mo , Jiang Hongyu , Wang Zhiguo , Yang Hailiang , Wang Jinhua 
Published: October 2022

A cylindrical reflex triode was designed and directly driven by a four-stage linear transformer driver to generate high intensity pulsed warm x rays. We developed a numerical model of the cylindrical reflex triode and simulated and studied the experimental electron distribution and the radiation characteristics. The working voltage of the cylindrical reflex triode is 220 kV, and the current is about 600 kA. Under the voltage pulse with a rise time of 100 ns, the electron beam spot is uniform, and the duration of the gap without short circuit reaches 200 ns. The x-ray dose is 385 rad (Si), with an irradiation area of 615 cm2 and a uniformity of less than 2:1. The radiation field distribution is basically consistent with the simulation results. Compared with the two-stage series diode on the Flash-II accelerator, the x-ray conversion efficiency of the cylindrical reflex triode is increased about 1.6 times.
Exact constraints and appropriate norms in machine-learned exchange-correlation functionals
Authors: Pokharel Kanun , Furness James W. , Yao Yi , Blum Volker , Irons Tom J. P. , Teale Andrew M. , Sun Jianwei 
Published: October 2022

Machine learning techniques have received growing attention as an alternative strategy for developing general-purpose density functional approximations, augmenting the historically successful approach of human-designed functionals derived to obey mathematical constraints known for the exact exchange-correlation functional. More recently, efforts have been made to reconcile the two techniques, integrating machine learning and exact-constraint satisfaction. We continue this integrated approach, designing a deep neural network that exploits the exact constraint and appropriate norm philosophy to de-orbitalize the strongly constrained and appropriately normed (SCAN) functional. The deep neural network is trained to replicate the SCAN functional from only electron density and local derivative information, avoiding the use of the orbital-dependent kinetic energy density. The performance and transferability of the machine-learned functional are demonstrated for molecular and periodic systems.
Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spines
Authors: Falahati Hanieh , Wu Yumei , Feuerer Vanessa , Simon Hans-Georg , De Camilli Pietro 
Published: October 2022

The spine apparatus is a specialized compartment of the neuronal smooth endoplasmic reticulum (ER) located in a subset of dendritic spines. It consists of stacks of ER cisterns that are interconnected by an unknown dense matrix and are continuous with each other and with the ER of the dendritic shaft. While this organelle was first observed over 60 y ago, its molecular organization remains a mystery. Here, we performed in vivo proximity proteomics to gain some insight into its molecular components. To do so, we used the only known spine apparatus–specific protein, synaptopodin, to target a biotinylating enzyme to this organelle. We validated the specific localization in dendritic spines of a small subset of proteins identified by this approach, and we further showed their colocalization with synaptopodin when expressed in nonneuronal cells. One such protein is Pdlim7, an actin binding protein not previously identified in spines. Pdlim7, which we found to interact with synaptopodin through multiple domains, also colocalizes with synaptopodin on the cisternal organelle, a peculiar stack of ER cisterns resembling the spine apparatus and found at axon initial segments of a subset of neurons. Moreover, Pdlim7 has an expression pattern similar to that of synaptopodin in the brain, highlighting a functional partnership between the two proteins. The components of the spine apparatus identified in this work will help elucidate mechanisms in the biogenesis and maintenance of this enigmatic structure with implications for the function of dendritic spines in physiology and disease.
Gluing blood into gel by electrostatic interaction using a water-soluble polymer as an embolic agent
Authors: Jin Zhiping , Fan Hailong , Osanai Toshiya , Nonoyama Takayuki , Kurokawa Takayuki , Hyodoh Hideki , Matoba Kotaro , Takeuchi Akiko , Gong Jian Ping , Fujimura Miki 
Published: October 2022

Liquid embolic agents are widely used for the endovascular embolization of vascular conditions. However, embolization based on phase transition is limited by the adhesion of the microcatheter to the embolic agent, use of an organic solvent, unintentional catheter retention, and other complications. By mimicking thrombus formation, a water-soluble polymer that rapidly glues blood into a gel without triggering coagulation was developed. The polymer, which consists of cationic and aromatic residues with adjacent sequences, shows electrostatic adhesion with negatively charged blood substances in a physiological environment, while common polycations cannot. Aqueous polymer solutions are injectable through clinical microcatheters and needles. The formed blood gel neither adhered to the catheter nor blocked the port. Postoperative computed tomography imaging showed that the polymer can block the rat femoral artery in vivo and remain at the injection site without nontarget embolization. This study provides an alternative for the development of waterborne embolic agents.