bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Air Quality Parameters at Different Locations of Tangail Sadar Upazila, Tangail
Authors: Rehnuma M , Riad AA , Shakur RI 
Published: July 2022

The study was conducted to investigate the concentration of PM2.5, PM10, CH4, CO2, CO, SO2 in the air of Tangail Sadar Upazila, Tangail. In the study area air quality data has been collected from eight sampling stations namely MBSTU campus, Baby stand, Nirala more, New bus stand, Rabna bypass, College gate, Old bus stand, Nogor jalfoi during dry season. The air quality data collected by using Aeroqual S 500 series. The concentrations of PM2.5, PM10, CH4, CO2, CO, SO2 found in air were ranged from 0.03-0.06, 0.04-0.10, 12.3-36, 919-1238.2, 0.00- 2.61, 0.00-0.48 mg/m3, respectively. The concentration of PM2.5, PM10, CO, SO2 that have been found were higher than Bangladesh standard and WHO guideline. Their sources could be the motor vehicles, road dust, coal burning, road construction, open dumping of solid waste in Tangail Sadar Upazila. Appropriate engine design control strategies and maintenance services should be introduced for reducing emission. Efficient solid waste management system should be introduced to control emission from construction sources.
Environ. Sci. & Natural Resources, 13(1&2): 118-122, 2020
Kinerja Keuangan Perusahaan Farmasi BUMN dan Non-BUMN Sebelum dan Selama Pandemi
Authors: Atmaja Michelia Yemima Hardwi , Davianti Arthik 
Published: July 2022

Since the emergence of COVID-19 in Indonesia, several corporate sectors in Indonesia have had their operational activities disrupted, which has caused a decline in revenue. However, there are industrial sectors that have benefited from the COVID-19 pandemic. One of them is the pharmaceutical industry. This study aims to determine the financial performance of public and private pharmaceutical companies before and during the pandemic. This research is descriptive quantitative research with the data source being secondary data. The data analysis technique uses net profit margin and returns on equity as profitability ratio, current ratio and quick ratio as liquidity ratio, total asset turnover and inventory turnover as activity ratio, debt to equity ratio, and debt to asset ratio as solvency ratios. The results show that private companies have better financial performance than public companies. Sido Muncul company has the best liquidity and solvency performance among other companies. Merck Indonesia has the best profitability performance, while Pyridam Farma has the best activity performance. In contrast, Indofarma has the worst performance among others even though in terms of activity performance, Indofarma is the most efficient company in selling products.

Sejak kemunculan COVID-19 di Indonesia, beberapa sektor perusahaan di Indonesia terganggu aktivitas operasionalnya yang menyebabkan penurunan pendapatan. Namun, terdapat sektor industri yang diuntungan dari adanya pandemi COVID-19. Salah satunya industri farmasi. Penelitian bertujuan untuk mengetahui kinerja keuangan perusahaan farmasi BUMN dan Non-BUMN sebelum dan selama pandemi. Penelitian ini merupakan penelitian kuantitatif deskriptif dengan sumber data yang digunakan berupa data sekunder. Teknik analisis data menggunakan analisis rasio profitabilitas yaitu net profit margin dan return on equity, rasio likuiditas yaitu current ratio dan quick ratio, rasio aktivitas yaitu total asset turnover dan inventory turnover, dan rasio solvabilitas yaitu debt to equity ratio dan debt to asset ratio. Hasil penelitian menunjukkan bahwa perusahaan Non-BUMN memiliki kinerja keuangan perusahaan yang lebih baik dari perusahaan BUMN. Hal ini dapat dilihat bahwa perusahaan Sido Muncul memiliki kinerja likuiditas dan solvabilitas paling baik diantara perusahaan lainnya. Kinerja profitabilitas paling baik dimiliki oleh perusahaan Merck Indonesia sedangkan Pyridam Farma memiliki kinerja aktivitas terbaik diantara lainnya. Sementara Indofarma memiliki kinerja paling buruk diantara lainnya meskipun pada kinerja aktivitas, Indofarma merupakan perusahaan yang paling efisien dalam menjual produknya.
INFLUENCE OF THE SOLVENT AND THE RATIO OF STARTING REAGENTS ON THE PROPERTIES OF ORGANIC-INORGANIC PEROVSKITE MAPbI3
Authors: Torchyniuk Pavlo , V'yunov Oleg , Vlasyuk Viktor , Kostylyov Vitaliy , Belous Anatolii 
Published: July 2022

The peculiarities of formation and properties of organiс-inorganic MAPbI3 perovskite films, obtained from solutions with different ratios of starting reagents (PbI2:MAI = 1:1,1:2, and 1:3), in the DMF and DMSO solvents, studied. As the PbI2:MAI ratio increases, the temperature of the formation of a single-phase MAPbI3 perovskite film also increases. The slight changes in the structural and electrophysical characteristics for perovskite films obtained at the different ratios of PbI2:MAI in DMF and DMSO were found. These changes are related to the solvent that is included in the crystalline structure of perovskite. In the same ratios of starting reagents, DMF is included in the structure of perovskite in a greater amount than DMSO.
A Novel Prognostic Score Including the CD4/CD8 for AIDS-Related Lymphoma
Authors: Chen Juanjuan , Liu Xuewu , Qin Shanfang , Ruan Guangjing , Lu Aili , Zhang Jinxin , Wu Yihua , Xie Zhiman , Peng Jie 
Published: July 2022

BackgroundA simple and clinically applicable prognostic scoring system for AIDS-related lymphoma (ARL) in the era of combination antiretroviral therapy (cART) is needed to better stratify patients’ risks and to assist in the decision-making of therapeutic strategies.MethodsWe conducted a retrospective multicenter cohort study in 138 primary ARL patients over an 8-year period from 2013 to 2020. Survival curves were estimated using the Kaplan–Meier method. Univariate and multivariate Cox proportional hazard models were performed to identify the association between patient-, lymphoma-, and HIV-specific variables with progression-free survival (PFS) and overall survival (OS). The incremental prognostic value of novel inflammatory biomarkers in the International Prognostic Index (IPI) was evaluated by comparing the receiver operating characteristic (ROC) curves, the concordance index (C-index), and the integrated Brier score (IBS).ResultsThe median age was 49.14 ± 14.20 (range 18–79) years, 81.9% were men, and the median follow-up was 44.94 (95% CI = 37.05–52.84) months. The 3-year OS and PFS were 39.4% (95% CI = 16.3–21.2) and 38.7% (95% CI = 14.5–19.7), respectively. We found that age, extranodal sites, bulky mass, CD4 T-cell counts, CD4/CD8 ratio, and hypoalbuminemia were associated with OS (all P &lt; 0.05) at both univariate and multivariate analyses. Of the new inflammatory markers, only the CD4/CD8 ratio was an independent prognostic parameter of OS and PFS. A lower CD4/CD8 ratio was strongly associated with adverse clinical factors, including older age, advanced Ann Arbor stage, more extranodal sites, elevated erythrocyte sedimentation rate, prior history of HIV, higher red cell distribution width ratio, hypoproteinemia, and emaciation. When the CD4/CD8 ratio was added to the IPI, the composite HIV-IPI score showed significantly better discrimination than IPI alone [AUC (95% CI): HIV-IPI, 0.83 (0.77–0.89) vs. IPI, 0.72 (0.70–0.85)]. The HIV-IPI model provided good predictive performance [C-index (95% CI): HIV-IPI, 0.82 (0.81–0.83) vs. IPI, 0.75 (0.73–0.77), P &lt; 0.001] and a satisfactory calibration function.ConclusionsThe CD4/CD8 ratio, an inexpensive and readily available marker, is a powerful independent prognostic parameter in patients with ARL. Furthermore, when the CD4/CD8 ratio is used in combination with IPI, it increases prognostic ability. The useful prediction of expected outcomes in ARL can inform treatment decisions.
A Comprehensive Analysis of Pyroptosis-Related lncRNAs Signature Associated With Prognosis and Tumor Immune Microenvironment of Pancreatic Adenocarcinoma
Authors: Zhao Kai , Li Xiangyu , Shi Yuanxin , Lu Yun , Qiu Peng , Deng Zhengdong , Yao Wei , Wang Jianming 
Published: July 2022

Background: Globally, pancreatic adenocarcinoma (PAAD) is a common and highly devastating gastrointestinal malignancy that seriously threatens human health. Pyroptosis refers to an emerging form of programmed cell death that has been discovered in recent years, and studies have demonstrated that long non-coding RNA (lncRNA) may act as a moderator in the pyroptosis process of cancer cells. However, relevant explorations about lncRNAs and pyroptosis are still insufficient in PAAD. Therefore, our research is designed to make a comprehensive analysis of the potential values of pyroptosis-related lncRNAs in PAAD.Methods: By integrating the RNA-sequencing, somatic mutation, and copy number variation (CNV) datasets, as well as the clinicopathological features, we established and validated a risk signature based on pyroptosis-related lncRNAs, and comprehensively analyzed its clinical significance and the potential connection with the tumor immune microenvironment (TIME).Consequences: The genetic variation landscape displayed that the somatic mutations were rare while CNV changes were general and mainly concentrated on copy number amplification of these 52 pyroptosis-related genes. Subsequently, a risk signature consisting of 10 lncRNAs (TRAF3IP2-AS1, LINC00519, LINC01133, LINC02251, AC005332.6, AL590787.1, AC090114.2, TRPC7-AS1, MIR223HG, and MIR3142HG) was constructed and patients were divided into different subgroups according to the median risk score; patients with high-risk scores presented worse outcomes compared to those with low-risk scores in the training, testing, and entire cohorts. Furthermore, patients at low-risk scores possessed a higher infiltration abundance of immune cells compared with high-risk patients, which was consistent with the expression levels of lncRNAs between the high/low-risk groups. Drug sensitivity analysis showed that low-risk scores were related to anti-cancer agents like AICAR and Axitinib, whereas high-risk scores were connected with certain drugs such as AUY922. These results demonstrated that our risk signature could be used for prognosis prediction; additionally, it was also related to the TIME that might act as a potential indicator to instruct immunotherapeutic strategies.Conclusion: This work explored the significance of the risk model constructed by pyroptosis-related lncRNAs in prognosis prediction and its internal link with the immune microenvironment of PAAD. The results are expected to assist in the diagnosis, prognostic assessment, and management of patients with PAAD.
Systematic Evaluation of Rheumatoid Arthritis Risk by Integrating Lifestyle Factors and Genetic Risk Scores
Authors: Yu Xing-Hao , Bo Lin , Cao Rong-Rong , Yang Yi-Qun , He Pei , Lei Shu-Feng , Deng Fei-Yan 
Published: July 2022

BackgroundEffective identification of high-risk rheumatoid arthritis (RA) individuals is still a challenge. Whether the combined effects of multiple previously reported genetic loci together with lifestyle factors can improve the prediction of RA risk remains unclear.MethodsBased on previously reported results and a large-scale Biobank dataset, we constructed a polygenic risk score (PRS) for RA to evaluate the combined effects of the previously identified genetic loci in both case-control and prospective cohorts. We then evaluated the relationships between several lifestyles and RA risk and determined healthy lifestyles. Then, the joint effects of healthy lifestyles and genetic risk on RA risk were evaluated.ResultsWe found a positive association between PRS and RA risk (OR = 1.407, 95% confidence interval (CI) = 1.354~1.463; HR = 1.316, 95% CI = 1.257~1.377). Compared with the low genetic risk group, the group with intermediate or high genetic risk had a higher risk (OR = 1.347, 95% CI = 1.213~1.496; HR = 1.246, 95% CI = 1.108~1.400) (OR = 2.169, 95% CI = 1.946~2.417; HR = 1.762, 95% CI = 1.557~1.995). After adjusting for covariates, we found protective effects of three lifestyles (no current smoking, regular physical activity, and moderate body mass index) on RA risk and defined them as healthy lifestyles. Compared with the individuals with low genetic risks and favorable lifestyles, those with high genetic risks and unfavorable lifestyles had as high as OR of 4.637 (95%CI = 3.767~5.708) and HR of 3.532 (95%CI = 2.799~4.458).ConclusionsIn conclusion, the integration of PRS and lifestyles can improve the prediction of RA risk. High RA risk can be alleviated by adopting healthy lifestyles but aggravated by adopting unfavorable lifestyles.
Case Report: Baricitinib as an Alternative in the Maintenance Therapy for Macrophage Activation Syndrome Secondary to Nodular Panniculitis
Authors: Yi Guanqun , Huang Zhengping , Huang Zhixiang , Wang Yunqing , Deng Weiming , Zheng Shaoling , Li Tianwang 
Published: July 2022

BackgroundMacrophage activation syndrome (MAS) is a severe complication of autoimmune diseases with high mortality. We report the effectiveness of baricitinib as an option for the maintenance therapy in MAS secondary to nodular panniculitis.Case summaryA 24-year-old female came to our hospital with repeated fever and a skin nodule on right tibial tuberosity. Results were notable for raised serum ferritin (SF), triglycerides (TG), elevated liver function enzymes, interleukin-6 (IL-6), interferon-γ (IFN-γ), soluble interleukin-2 receptor (sIL-2R) and decreased activity of NK cells. The pathological biopsy of the subcutaneous nodules indicated nodular panniculitis. Hemophagocytic cells were found in bone marrow aspiration. She was diagnosed as MAS secondary to nodular panniculitis. With the treatment of methylprednisolone (MP) and immunoglobulin, her symptoms and laboratory data gradually improved. Nevertheless, her disease relapsed when the MP dose was tapered. Regarding the usage of JAK inhibitors in MAS, we used baricitinib (JAK1/2 inhibitor) to treat MAS and her symptom and abnormal laboratory findings returned to normal. During follow-up, though the MP dose was tapered, she was stable without a MAS recurrence.ConclusionThe case report suggested baricitinib is an option for MAS in the maintenance therapy phase and is potentially beneficial to prevent recurrence.
Seasonally and Spatially Variable Organic Matter Contributions From Watershed, Marine Macrophyte, and Pelagic Sources to the Northeast Pacific Coastal Ocean Margin
Authors: St. Pierre Kyra A. , Hunt Brian P. V. , Giesbrecht Ian J. W. , Tank Suzanne E. , Lertzman Ken P. , Del Bel Belluz Justin , Hessing-Lewis Margot L. , Olson Angeleen , Froese Tyrel 
Published: July 2022

Globally, coastal waters are considered biogeochemical hotspots because they receive, transform, and integrate materials and waters from both land and the open ocean. Extending from northern California to southeast Alaska, the Northeast Pacific Coastal Temperate Rainforest (NPCTR) region is no exception to this, and hosts a diversity of watershed types (old-growth rainforest, bog forest, glaciers), and tidal (sheltered, exposed) and pelagic marine (deep fjord, shallow estuary, well-mixed channel) environments. With large freshwater fluxes to the coastal ocean, cross-ecosystem connectivity in the NPCTR is expected to be high, but seasonally variable, with pulses in runoff from rainfall, snowmelt and glacial melt, and primary production associated with changes in ocean upwelling and incident light. However, the relative contribution of each ecosystem to surface ocean organic matter pools over time and space remains poorly constrained, despite their importance for the structure and function of coastal marine ecosystems. Here, we use a four-year dataset of particulate organic matter (POM) chemical composition (δ13C, δ15N, C:N ratio) to quantify the relative contributions of watershed materials via riverine inputs, marine phytoplankton, and macrophytes (macroalgae and seagrass) to surface waters (0-10 m) at 11 stations representing fjord, shallow non-fjord estuary, sheltered channel and well-mixed coastal environments at the heart of the NPCTR in British Columbia, Canada. Watershed, marine phytoplankton, and macrophyte contributions to surficial POM ranged between 5-78%, 22-88%, and 0.1-18%, respectively, and varied by season and station. Watershed inputs were the primary source of POM across all stations in winter and were important throughout the year within the fjord. Marine phytoplankton were the principal source of POM in spring and at all stations outside of the fjord through summer and autumn, while macrophyte contributions were greatest in summer. These results demonstrated high, but seasonally and spatially variable, connectivity between ecosystems that are often considered in isolation of one another and highlight the need to consider coastal waters as integrated land-ocean meta-ecosystems. Future work should investigate how heterogeneity in POM sources determines its fate in coastal ecosystems,and the relative importance of different basal organic matter sources for the marine food web.
Airfoil Anemometer With Integrated Flexible Piezo-Capacitive Pressure Sensor
Authors: Ramanathan Arun K. , Headings Leon M. , Dapino Marcelo J. 
Published: July 2022

Demand is expected to accelerate for autonomous air vehicles that transport people and goods, making wind sensors on these vehicles and in the air space where they operate critical to ensure safe control of many simultaneous take-offs and landings. Conventional anemometers such as pitot tubes as well as rotating, heated-element, acoustic, and drag technologies have drawbacks for small and micro-aerial vehicles including high power consumption, high aerodynamic drag, complex signal processing, and high cost. This paper presents an airfoil-shaped anemometer that provides low drag while integrating sensors for measuring wind speed and direction on tethered kites, balloons, and drones. Wind speed is measured by an integrated dual-layer capacitive pressure sensor with a polyvinylidene fluoride (PVDF) diaphragm while wind direction is measured by a 3D digital magnetometer that senses the orientation of the airfoil relative to the earth’s magnetic field. A model is presented for a dual-layer capacitive sensor and validated through quasistatic pressure chamber testing. The capacitive sensor as well as a commercial digital magnetometer are integrated into a NACA 2412 profile airfoil and tested in a laboratory-scale wind tunnel. The capacitive sensor provides a sensitivity of 1.84 fF m2s−2 and the airfoil exhibits a unique stable angle-of-attack to within ±2° as measured by the magnetometer.
Exploring the Pharmacological Mechanism of the Effective Chinese Medicines Against Gynecological Cancer Based on Meta-Analysis Combined With Network Pharmacology Analysis
Authors: Ren Ning , Yu Lulin , Qian Lihui , Ye Gewei , Zhu Zhenzheng , Yu Jieru , Sun Leitao , Zhang Leyin 
Published: July 2022

This meta-analysis plus network pharmacology aimed to investigate whether traditional Chinese medicine (TCM) combined with chemotherapy is associated with more beneficial efficacy data in the treatment of gynecological cancer (GC). A total of 11 randomized controlled trials (RCTs) consisting of 863 GC patients were included. Results showed a better ORR (RR: 1.42, 95% CI: 1.18–1.71; I2 = 21.4%; p = 0.282), DCR (RR: 1.13, 95% CI: 1.03–1.25; I2 = 0.0%; p = 0.492), PD (RR: 0.27, 95% CI: 0.11–0.65, p = 0.003; I2 = 0.0%, p = 0.930), and QOL (SMD: 0.85, 95% CI: 0.38–1.33, p = 0.005) and higher proportions of CD3+ T (WMD: 5.65, 95% CI: 4.23–7.08, p = 0.000; I2 = 68.3%, p = 0.004), CD4+ T (WMD: 6.97, 95% CI: 5.35–8.59, p = 0.000; I2 = 83.4%, p = 0.000), and the CD4+/CD8+ T ratio (WMD: 0.32, 95% CI: 0.23–0.42, p = 0.000; I2 = 78.0%, p = 0.000). The number of adverse events (AEs) was significantly lower in the TCM + chemotherapy group. The active components and targets of 19 high-frequency Chinese medicines obtained from the meta-analysis were screened and explored in network pharmacology analysis. Also, a regulatory network of active components and targets, a core network and key genes, a diagram of protein interaction, network topology analysis, and gene body GO function and KEGG pathway enrichment analysis were performed. A total of 120 active components were identified. NPM1 and HSPA8 are the most critical target proteins in the core network of protein interaction. HSP90AA1 is the most important target protein in the TCM group. KEGG enrichment analysis showed that it was highly significant in the lipid and atherosclerotic pathways. Therefore, moderate evidence revealed that TCM plus chemotherapy has obvious advantages over chemotherapy alone in terms of tumor responses, QOL, peripheral blood lymphocyte levels, and fewer AEs in the treatment of GC. The potential important targets and core genes were displayed.Systematic Review Registrationwww.crd.york.ac.uk/PROSPERO/, identifier CRD42021252500.
The Application of Nimotuzumab Combined With Definitive Chemoradiotherapy Toward the Treatment of Locally Advanced Cervical Esophageal Carcinoma: A Retrospective Study
Authors: Hu Jing , Chen Zhe , Lv Jiaming , Zheng Zhen , Bei Yanping , Chen Xue , Zheng Lu , Song Wenjie , Xu Yunbao 
Published: July 2022

ObjectiveTo evaluate the safety and effectiveness of nimotuzumab in combination with chemoradiotherapy for locally advanced cervical esophageal squamous cell carcinoma.MethodsRetrospective analysis was conducted from September 2012 to February 2017 among 50 locoregional-advanced cervical esophageal carcinoma (CEC) patients who received concurrent chemoradiotherapy (CRT) combined with or without nimotuzumab at Ningbo Medical Center Lihuili Hospital. Intensity-modulated radiotherapy (IMRT) was administrated on all patients. All patients were divided into two groups, of which 26 (Group A) received 200 mg (22 of 50) or 400 mg (4 of 50) of nimotuzumab per week with CRT and 24 (Group B) received definitive CRT.ResultsThe median follow-up time was 23 months. The median overall survival (OS) and progression-free survival (PFS) were 40.6 and 21.1 months for all, respectively. The 1-, 2-, and 3-year OS rates on the whole were 79.6%, 62.1%, and 47.8%. There was no statistical difference in overall response rate and disease control rate between the two groups. Patients treated with nimotuzumab (group A) had better PFS than the definitive CRT group (group B) (P &lt; 0.05). However, the median OS was 41.4 months in group A and 32.4 months in group B, respectively (P = 0.517). Multivariate analysis showed that PFS among those with lower Eastern Cooperative Oncology Group (ECOG) score (HR = 5.11; P &lt; 0.01), stage II (HR = 9.52; P &lt; 0.01) and the application of nimotuzumab combined with CRT (HR = 0.16; P &lt; 0.01) was much longer. Furthermore, ECOG, stage, C-reactive protein (CRP) baseline, and histological grade can also be used as independent predictors of OS. Grade &gt;3 adverse reactions were not observed. The most common adverse event related to nimotuzumab was mild fever and the occurrence rate was 19% (5 of 26). The incidence of anemia was 65.4% in group A and 87.5% in group B (P &lt; 0.05).ConclusionsFor locoregional-advanced CEC, nimotuzumab combined with IMRT and concomitant chemotherapy was tolerated and effective. In addition, patients with a normal pretherapeutic serum CRP level (CRP &lt; 10 mg/L) can achieve better OS.