bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of research in activity-based working over the last ten years: lessons for the post-COVID workplace
Authors: Marzban Samin , Candido Christhina , Mackey Martin , Engelen Lina , Zhang Fan , Tjondronegoro Dian 
Published: January 2022

Purpose
The purpose of this paper is to map and describe findings from research conducted in workspaces designed to support activity-based working (ABW) over the past 10 years (2010–2020) with a view of informing post-COVID workplaces of the positive and negative attributes of ABW.

Design/methodology/approach
Scopus was used as the search engine for this review. Papers which reported findings related to ABW and performed field study in ABW workspaces with adult occupants were included. Out of the 442 initial papers, 40 papers were included following iterative title and abstract and full text review process and consideration of inclusion and exclusion criteria. These papers were divided into three groupings (organizational, human and physical environment) based on their major focus. Positive and negative effects of ABW environments on occupants are discussed within these three topics in consideration of the implications for the post-COVID workplace.

Findings
Although the included studies were inclined to be either more positive (i.e. interior design) or negative (i.e. indoor environmental quality, productivity, distraction and privacy) in relation to various attributes of ABW, no single effect of ABW environments on occupants was in full agreement between the studies. The shortcomings of ABW environments are more related to how this way of working is implemented and how occupants use it, rather than the concept itself. A partial uptake of ABW leads to occupants’ dissatisfaction, lower productivity and lower well-being, while a holistic approach increases the chance of success. It is hypothesised that many currently reported negative aspects of the ABW concept might diminish overtime as ABW evolves and as new challenges arise. A continuous post-occupancy evaluation after relocation to an ABW-supportive environment can inform the organization about the changing needs and preference of the occupants; hence, the organization can tailor the ABW solution to the arising needs. The inter-connection between the three key ABW pillars (organizational, human and physical environment) is crucial to the success of this concept specifically in the context of the post-COVID-19 workplace.

Originality/value
This paper highlights the key shortcomings and limitations of studies produced over the past decade and identifies keys gaps in the current body of literature. It provides a new insight on how findings related to open-plan offices designed to support ABW can be categorized on the three big heading of organizational, physical and human-related aspects, and further investigates the positive and negatives outcomes reported on ABW under these headings. It also discusses how the findings arising from this literature review can inform the post-COVID workplace.
From ivory tower to a storyteller of value creation: integrated reporting at Japanese and South African universities
Authors: Sun Yanqi , Ip Pui San , Arunachalam Murugesh , Davey Howard 
Published: January 2022

PurposeThe paper examines integrated reporting (IR) practices of two Japanese universities and three South African universities by evaluating and comparing their 2019 integrated reports.Design/methodology/approachA multiple case study research method is used in this study.FindingsThe paper reveals that IR is in its infancy at the sample universities. Some universities have initiated disclosing information to their stakeholders on how they create value. However, the universities lack a comprehensive approach to integrating financial and non-financial information, thereby affecting the IR disclosure quality. The findings indicate that informal coercive pressure of South African universities is a primary driving factor that enables the universities to achieve a higher IR disclosure quality than their Japanese counterparts.Research limitations/implicationsThis paper argues that institutional theory is relevant for explaining the differences in IR practices of the universities in the two different jurisdictional settings.Practical implicationsThe research will be of interest to university administrators, policymakers, regulators and other stakeholder groups of universities. The assessment of integrated reports serves as a first step to help the universities improve IR practices as well as to facilitate the diffusion of IR in higher education institutions (HEIs) globally. There is also a need for universities to pay more attention to the storytelling of their value creation in future IR disclosures.Originality/valueIt is the first to assess the IR quality of the Japanese sample universities as well as the first to conduct a comparative analysis for IR practices of universities in two different jurisdictional settings that have adopted IR. The findings of this study add to the current scholarly debate on universities' ability to tell their stories on their value creation to stakeholders via integrated reports.
Rapid response pathway united to reduce self-harm (RUSH): a case study of a pilot pathway for children and young people
Authors: Cross Molly , Clarke Tim 
Published: January 2022

Purpose
In response to elevated local self-harm and suicide rates, and the lack of a dedicated pathway for children and young people (CYP) who self-harm, a rapid response pathway united to reduce self-harm (RUSH) was developed and implemented within Norwich (Norfolk, England). This public health case study aims to describe the pathway model and share its outcomes, learnings, and reflections over the pilot year.

Design/methodology/approach
RUSH was a community-based pilot pathway aiming to support CYP, 11–18 years old, engaging in or at risk of engaging in repeated self-harm and subsequently at risk of repeated attendance at local emergency departments. From May 2020 to April 2021, RUSH supported 61 CYP using funding from NHS England and Improvement.

Findings
This case study shares the pathway’s outcomes, through a mixed-method evaluation. Results indicate statistically significant reductions in self-harm frequency (p = 0.01) and anxiety and depression symptomatology (p < 0.001); a statistically significant increase in progress towards goals (p < 0.001); and a general downward trend in re-attendance at local emergency departments following RUSH. Findings also illustrate high service user satisfaction. Framework analysis of focus group data highlights positive experiences with hope for recommissioning from a staff perspective.

Originality/value
This study will be valuable for services looking to develop and implement a similar service provision, in response to the need to tackle self-harm rates as a broader approach to suicide prevention. In light of the NHS long-term plan (2019), it also serves as an example of how to develop and use a strategic co-production group, and work collaboratively with the voluntary, community and social enterprise sectors.
Ferguson as a distal crisis: Chief assessments of changes in the police institutional environment
Authors: Jurek Alicia L. , Matusiak Matthew C. , King William R. 
Published: January 2022

Research SummaryWe explore how a widely publicized crisis in another jurisdiction, a distal crisis, affects police agencies that were far removed from the crisis. Using data from a two‐wave, panel‐design survey of 411 police chiefs in Texas, we investigate how the events occurring in Ferguson, Missouri during 2014 changed chiefs’ perceptions of their institutional environmental sectors. Although distant from Ferguson, in the immediate aftermath chiefs rated two (local and national media) of eight (federal, state, and local law enforcement organizations as well as elected officials, police employee associations, local emergency medical organizations, and local advocacy groups) institutional sectors (including local and national media) as less impactful or legitimate.Policy ImplicationsPolice leaders react to crises involving other, distant agencies. Events in Ferguson led chiefs in Texas to rate the media as less potentially impactful for their agency, a change that signals decreasing legitimacy of the media in the eyes of the police. Increased animus between the media and police may threaten the media's effectiveness as watchdogs of policing and impede cooperation between the police and media.
News media and public attitudes toward the protests of 2020: An examination of the mediating role of perceived protester violence
Authors: Baranauskas Andrew J. 
Published: January 2022

AbstractResearch SummaryThis study investigates the role of the news media in shaping attitudes toward the protests of 2020. Using data from a nationally representative election survey, it examines the association between news consumption and support for law‐and‐order policies to address protest violence, with perceptions that the protesters were violent as a potential mediator. Findings indicate that viewers of online news are less likely to support law‐and‐order policies. This relationship is mediated by perceived protester violence, with perceived violence enhancing support for law‐and‐order policies. Further examination shows that political bias plays a role: viewers of left‐leaning sites are less likely to support law‐and‐order policies to address protest violence, while viewers of right‐leaning sites are more likely. These relationships are also mediated by perceived violence.Policy ImplicationsA slight majority of respondents indicate that they lean toward solving problems of racism and police violence, indicating that much of the American public is open to criminal justice reform. Perceived violence helps to shape the association of online news media with support for law‐and‐order policies. Activists should avoid violence in their protests and use Internet‐based media sources to publicize their peaceful activities and demands. Law enforcement agencies should use the Internet and social media to keep the public informed of the reality of protests, especially of any violence that occurs, in an effort to justify forceful tactics.
Hyperproduction of PHA copolymers containing high fractions of 4‐hydroxybutyrate (4HB) by outer membrane‐defected Halomonas bluephagenesis grown in bioreactors
Authors: Wang Ziyu , Zheng Yifei , Ji Mengke , Zhang Xu , Wang Huan , Chen Yuemeng , Wu Qiong , Chen Guo‐Qiang 
Published: January 2022

SummaryBacterial outer membrane (OM) is a self‐protective and permeable barrier, while having many non‐negligible negative effects in industrial biotechnology. Our previous studies revealed enhanced properties of Halomonas bluephagenesis based on positive cellular properties by OM defects. This study further expands the OM defect on membrane compactness by completely deleting two secondary acyltransferases for lipid A modification in H. bluephagenesis, LpxL and LpxM, and found more significant advantages than that of the previous lpxL mutant. Deletions on LpxL and LpxM accelerated poly(3‐hydroxybutyrate) (PHB) production by H. bluephagenesis WZY229, leading to a 37% increase in PHB accumulation and 84‐folds reduced endotoxin production. Enhanced membrane permeability accelerates the diffusion of γ‐butyrolactone, allowing H. bluephagenesis WZY254 derived from H. bluephagenesis WZY229 to produce 82wt% poly(3‐hydroxybutyrate‐co‐23mol%4‐hydroxybutyrate) (P(3HB‐co‐23mol%4HB)) in shake flasks, showing increases of 102% and 307% in P(3HB‐co‐4HB) production and 4HB accumulation, respectively. The 4HB molar fraction in copolymer can be elevated to 32 mol% in the presence of more γ‐butyrolactone. In a 7‐l bioreactor fed‐batch fermentation, H. bluephagenesis WZY254 supported a 84 g l−1 dry cell mass with 81wt% P(3HB‐co‐26mol%4HB), increasing 136% in 4HB molar fraction. This study further demonstrated that OM defects generate a hyperproduction strain for high 4HB containing copolymers.
Signalling long‐term focus through textual emphasis on innovation: are firms putting their money where their mouth is?
Authors: Enache Luminita , Fogel‐Yaari Hila , Li Heather 
Published: January 2022

AbstractMost Form 10‐K filings include non‐informative innovation‐related words. This study shows that textual emphasis on innovation (TEI) reflects the firm’s intention to focus on the long term and finds TEI to be trustworthy. TEI is positively associated with a firm’s long‐term investment and negatively associated with a firm’s under‐investment. Trustworthiness increases when the firm is subject to increased scrutiny. However, this signal is costly, because it is associated with over‐investment in innovation. The study contributes to the impression management and soft disclosure literatures and presents an efficient firm‐level measure in fighting short‐termism pressure.
A mathematical estimation for quantified calcium supplementation during intermittent hemodialysis using regional citrate anticoagulation
Authors: Bi Xiao , Zhang Qi , Zhuang Feng , Ding Feng 
Published: January 2022

AbstractBackgroundRegional citrate anticoagulation has been recommended as an alternative of anticoagulation for patients at high risk of bleeding undergoing intermittent hemodialysis. Precise calcium supplementation is important for the safety of regional citrate anticoagulation. In this study, we aimed to develop a possible method to optimize calcium supplementation for regional citrate anticoagulation in intermittent hemodialysis.MethodsThe investigation consisted of a pilot study and a validation study. 18 patients undergoing intermittent hemodialysis anticoagulated by citrate, and six types of filters were included in the pilot study. The ionized calcium levels were monitored and maintained in the targeted range. Calcium‐free dialysate was used in the study. After linear regression analysis of the clearance of non‐protein bound calcium and calculating the ratio of the non‐protein bound calcium concentration to total calcium concentration, we developed a mathematical model for estimation of extracorporeal circuit calcium removal. Another 8 maintenance hemodialysis patients (12 sessions) were enrolled in the validation study to validate the new version of the calcium supplementation approach.ResultsIn the pilot study, positive correlations were found between the clearance of non‐protein bound calcium and the hematocrit‐adjusted clearance of creatinine and phosphate given in the dialyzer leaflet (R2 = 0.31, p = 0.0165). The ratio of the non‐protein bound calcium concentration to total calcium concentration at the pre‐filter point after infusion of citrate were constant about 0.75. In the validation study, we found that the systemic ionized calcium levels were stably maintained in the safe range and no filter clotting occurred during the hemodialysis when we used the new model of calcium supplementation.ConclusionsWe developed a possible method to quantify calcium supplementation for intermittent hemodialysis anticoagulated by citrate which may help to avoid negative calcium balance and reduce the incidence of complications.
Enhanced phosphate absorption in intestinal epithelial cell‐specific NHE3 knockout mice
Authors: Xue Jianxiang , Thomas Linto , Murali Sathish Kumar , Levi Moshe , Fenton Robert A. , Dominguez Rieg Jessica A. , Rieg Timo 
Published: January 2022

AbstractAimsThe kidneys play a major role in maintaining Pi homeostasis. Patients in later stages of CKD develop hyperphosphatemia. One novel treatment option is tenapanor, an intestinal‐specific NHE3 inhibitor. To gain mechanistic insight into the role of intestinal NHE3 in Pi homeostasis, we studied tamoxifen‐inducible intestinal epithelial cell‐specific NHE3 knockout (NHE3IEC‐KO) mice.MethodsMice underwent dietary Pi challenges, and hormones as well as urinary/plasma Pi were determined. Intestinal 33P uptake studies were conducted in vivo to compare the effects of tenapanor and NHE3IEC‐KO. Ex vivo Pi transport was measured in everted gut sacs and brush border membrane vesicles. Intestinal and renal protein expression of Pi transporters were determined.ResultsOn the control diet, NHE3IEC‐KO mice had similar Pi homeostasis, but a ~25% reduction in FGF23 compared with control mice. Everted gut sacs and brush border membrane vesicles showed enhanced Pi uptake associated with increased Npt2b expression in NHE3IEC‐KO mice. Acute oral Pi loading resulted in higher plasma Pi in NHE3IEC‐KO mice. Tenapanor inhibited intestinal 33P uptake acutely but then led to hyper‐absorption at later time points compared to vehicle. In response to high dietary Pi, plasma Pi and FGF23 increased to higher levels in NHE3IEC‐KO mice which was associated with greater Npt2b expression. Reduced renal Npt2c and a trend for reduced Npt2a expression were unable to correct for higher plasma Pi.ConclusionIntestinal NHE3 has a significant contribution to Pi homeostasis. In contrast to effects described for tenapanor on Pi homeostasis, NHE3IEC‐KO mice show enhanced, rather than reduced, intestinal Pi uptake.
MAFA and MAFB regulate exocytosis‐related genes in human β‐cells
Authors: Cataldo Luis Rodrigo , Singh Tania , Achanta Kavya , Bsharat Sara , Prasad Rashmi B. , Luan Cheng , Renström Erik , Eliasson Lena , Artner Isabella 
Published: January 2022

AbstractAimsReduced expression of exocytotic genes is associated with functional defects in insulin exocytosis contributing to impaired insulin secretion and type 2 diabetes (T2D) development. MAFA and MAFB transcription factors regulate β‐cell physiology, and their gene expression is reduced in T2D β cells. We investigate if loss of MAFA and MAFB in human β cells contributes to T2D progression by regulating genes required for insulin exocytosis.MethodsThree approaches were performed: (1) RNAseq analysis with the focus on exocytosis‐related genes in MafA−/− mouse islets, (2) correlational analysis between MAFA, MAFB and exocytosis‐related genes in human islets and (3) MAFA and MAFB silencing in human islets and EndoC‐βH1 cells followed by functional in vitro studies.ResultsThe expression of 30 exocytosis‐related genes was significantly downregulated in MafA−/− mouse islets. In human islets, the expression of 29 exocytosis‐related genes correlated positively with MAFA and MAFB. Eight exocytosis‐related genes were downregulated in MafA−/− mouse islets and positively correlated with MAFA and MAFB in human islets. From this analysis, the expression of RAB3A, STXBP1, UNC13A, VAMP2, NAPA, NSF, STX1A and SYT7 was quantified after acute MAFA or MAFB silencing in EndoC‐βH1 cells and human islets. MAFA and MAFB silencing resulted in impaired insulin secretion and reduced STX1A, SYT7 and STXBP1 (EndoC‐βH1) and STX1A (human islets) mRNA expression. STX1A and STXBP1 protein expression was also impaired in islets from T2D donors which lack MAFA expression.ConclusionOur data indicate that STXBP1 and STX1A are important MAFA/B‐regulated exocytosis genes which may contribute to insulin exocytosis defects observed in MAFA‐deficient human T2D β cells.
Peptide fragments of bradykinin show unexpected biological activity not mediated by B1 or B2 receptors
Authors: Souza‐Silva Igor Maciel , de Paula Cristiane Amorim , Bolais‐Ramos Lucas , Santos Anderson Kenedy , da Silva Filipe Alex , de Oliveira Vívian Louise Soares , da Rocha Isabella Domingos , Antunes Maísa Mota , Cordeiro Lídia Pereira Barbosa , Teixeira Vanessa Pereira , Scalzo Júnior Sérgio Ricardo Aluotto , Raabe Adriana Campezatto , Guimaraes Pedro Pires Goulart , Amaral Flávio Almeida , Resende Jarbas Magalhães , Fontes Marco Antônio Peliky , Menezes Gustavo Batista , Guatimosim Silvia , Santos Robson Augusto Souza , Verano‐Braga Thiago 
Published: January 2022

Background and PurposeBradykinin (BK‐(1–9)) is an endogenous nonapeptide involved in multiple physiological and pathological processes. Peptide fragments of bradykinin are believed to be biologically inactive. We have now tested the two major peptide fragments of bradykinin in human and animals.Experimental ApproachBK peptides were quantified by MS in male rats. NO release was quantified from human, mouse and rat cells loaded with DAF‐FM. Rat aortic rings were used to measure vascular reactivity. Changes in BP and HR were measured in conscious male rats. To evaluate pro‐inflammatory effects both vascular permeability and nociception were measured in adult mice.Key ResultsBK‐(1–7) and BK‐(1–5) are produced in vivo from BK‐(1–9). Both peptides induced NO production in all cell types tested. However, unlike BK‐(1–9), NO production elicited by BK‐(1–7) or BK‐(1–5) was not inhibited by B1 or B2 receptor antagonists. BK‐(1–7) and BK‐(1–5) induced concentration‐dependent vasorelaxation of aortic rings, without involvement of B1 or B2 receptors. Intravenous or intra‐arterial administration of BK‐(1–7) or BK‐(1–5) induced similar hypotensive response in vivo. Nociceptive responses of BK‐(1–7) and BK‐(1–5) were reduced compared to BK‐(1–9), and no increase in vascular permeability was observed for BK‐(1–9) fragments.Conclusions and ImplicationsBK‐(1–7) and BK‐(1–5) are endogenous peptides present in plasma. BK‐related peptide fragments show biological activity, not mediated by B1 or B2 receptors. These BK fragments could constitute new, active components of the kallikrein–kinin system.
Normative coherence for development and regionalism: Gender equality in ASEAN's migration policies
Authors: Häbel Sandra , Koff Harlan , Adam Marie 
Published: January 2022

SummaryMotivationThe United Nations 2030 Agenda recognizes regions as important actors in implementing the sustainable development agenda. At the same time, regions are often criticized for lacking effective implementation, especially in relation to gender equality.PurposeThis study examines whether the Association of Southeast Asian Nations (ASEAN) implements its global commitment to gender equality at a regional level.Methods and approachWe apply qualitative analysis of key ASEAN documents in order to determine how gender equality is implemented regionally. We particularly focus on frameworks related to female migrant workers in ASEAN.FindingsThe analysis shows that ASEAN is formally committed to improving gender equality at a regional level, however, female migrants often end up in unfavourable conditions and precarious work relationships without any institutionalized protection because ASEAN's gender equality initiatives are largely concentrated in the Cultural Community and absent from the Economic Community, indicating an absence of normative coherence for development with regard to gender equality.Policy implicationsThis limited impact of emerging regional commitments to gender equality arises from incoherences in ASEAN's normative governance framework which undermine normative coherence for development at the regional level.