bluuebunny/crossref_metadata_2025_split huggingface dataset:
Putting the individual and context back into national human resource development research: A systematic review and research agenda
Authors: Garavan Thomas , Wang Jia , Nolan Ciara , Lai Yanqing , O'Brien Fergal , Darcy Colette , Matthews‐Smith Gerri , McLean Gary 
Published: July 2022

AbstractConceptualization of national human resource development (NHRD) emphasizes that it is an ongoing development process of the individual that is shaped by context. However, the extant literature has focused primarily on describing and evaluating NHRD policies and interventions in different countries with limited consideration of NHRD across the lifespan and the interaction of life stage with context. Using ecological systems theory (EST) and a lifespan development perspective (LDP), we present a systematic review of the NHRD literature based on 310 sources. We identify key themes and gaps in research across the lifespan and at distinct levels of the ecological system. We build on this review to suggest future research informed by both EST and an LDP. We propose a future research agenda focused on several key areas, including: the developing individual as the primary focus of NHRD; the dynamic relationship between NHRD microsystems and how this evolves over time; the exosystem and macrosystem, which provide the context of the NHRD development experience for the individual over their lifespan; and the imperatives of directing research attention to top‐down and bottom‐up influences within the ecological system. We also propose three methodological innovations to address many of the questions raised by our review, drawing on national archive databases, the use of historical methods and a focus on longitudinal data analysis. Finally, we highlight the practical implications of our analysis for ecosystem and microsystem NHRD actors.
Binding properties of odorant‐binding protein 4 from bean bug Riptortus pedestris to soybean volatiles
Authors: Zhu Xiu‐Yun , Li Jin‐Bu , Liu Jia , Dewer Youssef , Zhang Hui , Zhang Hui‐Ru , Zhang Dong , Zhang Xiao‐Ya , Wan Zhi‐Wei , Yin Mao‐Zhu , Li Xiao‐Ming , Zhang Ya‐Nan 
Published: July 2022

AbstractThe bean bug Riptortus pedestris is a notorious insect pest that can damage various crops, especially soybean, in East Asia. In insects, the olfactory system plays a crucial role in host finding and feeding behaviour in which the odorant‐binding proteins (OBPs) are believed to be involved in initial step in this system. In this study, we produced the R. pedestris adult antennae‐expressed RpedOBP4 protein using a recombinant expression system in E. coli. Fluorescence competitive binding confirmed that RpedOBP4 has binding affinities to 7 of 20 soybean volatiles (ligands), and that a neutral condition is the best environment for it. The binding property of RpedOBP4 to these ligands was further revealed by integrating data from molecular docking, site‐directed mutagenesis and ligand binding assays. This demonstrated that five amino acid residues (I30, L33, Y47, I57 and Y121) are involved in the binding process of RpedOBP4 to corresponding ligands. These findings will not only help us to more thoroughly explore the olfactory mechanism of R. pedestris during feeding on soybean, but also lead to the identification of key candidate targets for developing environmental and efficient behaviour inhibitors to prevent population expansion of R. pedestris in the future.
Human breast milk‐derived exosomes through inhibiting AT II cell apoptosis to prevent bronchopulmonary dysplasia in rat lung
Authors: Zhou Yahui , Liu Yiwen , Xu Gen , Liu Lingjie , Li Huimin , Li Yubai , Yin Jing , Wang Xingyun , Yu Zhangbin 
Published: July 2022

AbstractHuman breast milk (HBM) effectively prevents and cures neonatal bronchopulmonary dysplasia (BPD). Exosomes are abundant in breast milk, but the function of HBM‐derived exosomes (HBM‐Exo) in BPD is still unclear. This study was to investigate the role and mechanism of HBM‐Exo in BPD. Overall lung tissue photography and H&E staining showed that HBM‐Exo improved the lung tissue structure collapse, alveolar structure disorder, alveolar septum width, alveolar number reduction and other injuries caused by high oxygen exposure. Immunohistochemical results showed that HBM‐Exo improved the inhibition of cell proliferation and increased apoptosis caused by hyperoxia. qPCR and Western blot results also showed that HBM‐Exo improved the expression of Type II alveolar epithelium (AT II) surface marker SPC. In vivo study, CCK8 and flow cytometry showed that HBM‐Exo improved the proliferation inhibition and apoptosis of AT II cells induced by hyperoxia, qPCR and immunofluorescence also showed that HBM‐Exo improved the down‐regulation of SPC. Further RNA‐Seq results in AT II cells showed that a total of 88 genes were significantly different between the hyperoxia and HBM‐Exo with hyperoxia groups, including 24 up‐regulated genes and 64 down‐regulated genes. KEGG pathway analysis showed the enrichment of IL‐17 signalling pathway was the most significant. Further rescue experiments showed that HBM‐Exo improved AT II cell damage induced by hyperoxia through inhibiting downstream of IL‐17 signalling pathway (FADD), which may be an important mechanism of HBM‐Exo in the prevention and treatment of BPD. This study may provide new approach in the treatment of BPD.
Autogenous bone block versus collagenated xenogeneic bone block in the reconstruction of the atrophic alveolar ridge: A non‐inferiority randomized clinical trial
Authors: Romito Giuseppe Alexandre , Villar Cristina Cunha , Sapata Vitor Marques , Soares Herbert Horiuti , Fonseca Marcelo Augusto , Conde Marina , Hammerle Christoph Hans Franz , Schwarz Frank 
Published: July 2022

AbstractAimTo compare the efficacy of equine‐derived collagenated xenogeneic bone blocks (CXBB) and autogenous bone block (ABB) for lateral alveolar ridge augmentation and two‐stage implant placement.Materials and MethodsSixty‐four patients with tooth gaps up to four teeth and atrophic alveolar ridges with ≤4 mm were randomly assigned to lateral augmentation using CXBB or ABB. Lateral bone thickness (LBT) was measured 2 mm below the alveolar crest at augmentation surgery and 30 weeks later at implant placement. Implant‐related outcomes, adverse events, surgery duration, pain sensation, analgesic consumption, and oral health‐related quality of life were also assessed. Data were analysed using Fisher's exact, Mann–Whitney, and Wilcoxon signed‐rank tests.ResultsAt 30 weeks, the median change in LBT amounted to 2.90 (CXBB) and 3.00 (ABB), respectively. Secondary endpoints demonstrated similar results for CXBB and ABB in terms of possibility to place an implant, need to perform a secondary bone augmentation at implant placement and rate of complications. Early implant failure was 20% for CXBB and 10% for ABB, with no difference between the groups. Pain scores and post‐operative consumption of analgesics were significantly lower in the CXBB group than in the ABB group, especially during the first days post‐surgery.ConclusionsCXBB is non‐inferior to ABB for horizontal alveolar ridge augmentation and two‐stage implant placement.
Bilirubin as a new antioxidant in melasma
Authors: Rahimi Hoda , Mirnezami Mina , Yazdabadi Anousha 
Published: July 2022

AbstractBackgroundOxidative stress and its role in the pathogenesis of cutaneous diseases have been widely investigated. However, there are few studies that have solely assessed the contribution of intracellular antioxidants in the etiopathology of melasma. Furthermore, there are convincing reports about antioxidant properties of bilirubin (Bil) and uric acid (UA) in some skin disorders but not melasma.ObjectiveThis study aimed to determine serum levels of two major extracellular antioxidants (Bil and UA) levels in patients with melasma and their correlation with the severity and extent of the disease.MethodsIn this case‐control study, the serum levels of bilirubin and uric acid of 50 melasma patients were compared with 50 healthy controls. Moreover, the correlation of serum concentrations of these antioxidants with the extent and severity of the disease were assessed.ResultsThe serum concentration of Bil was significantly higher in the case group (p < 0.05). Furthermore, serum Bil level had a positive correlation with the extent of the melasma (correlation coefficient, +0.3;p < 0.05). No significant difference was found between the serum concentrations of UA between the study and control group. Neither Bil nor UA had a significant correlation with the severity of the disease.ConclusionOxidative stress may play a major role in the etiopathology of melasma and bilirubin, as an antioxidant, could be involved in the process of oxidative stress.
Pharmacokinetic/pharmacodynamic modeling of ketoprofen and flunixin at piglet castration andtail‐docking
Authors: Nixon Emma , Chittenden Jason T. , Baynes Ronald E. , Messenger Kristen M. 
Published: July 2022

AbstractThis study performed population‐pharmacokinetic/pharmacodynamic (pop‐PK/PD) modeling of ketoprofen and flunixin in piglets undergoing routine castration and tail‐docking, utilizing previously published data. Six‐day‐old male piglets (8/group) received either ketoprofen (3.0 mg/kg) or flunixin (2.2 mg/kg) intramuscularly. Two hours post‐dose, piglets were castrated and tail docked. Inhibitory indirect response models were developed utilizing plasma cortisol or interstitial fluid prostaglandin E2 (PGE2) concentration data. Plasma IC50 for ketoprofen utilizing PGE2 as a biomarker was 1.2 μg/ml, and ED50 for was 5.83 mg/kg. The ED50 calculated using cortisol was 4.36 mg/kg; however, the IC50 was high, at 2.56 μg/ml. A large degree of inter‐individual variability (124.08%) was also associated with the cortisol IC50 following ketoprofen administration. IC50 for flunixin utilizing cortisol as a biomarker was 0.06 μg/ml, and ED50 was 0.51 mg/kg. The results show that the currently marketed doses of ketoprofen (3.0 mg/kg) and flunixin (2.2 mg/kg) correspond to drug responses of 33.97% (ketoprofen‐PGE2), 40.75% (ketoprofen‐cortisol), and 81.05% (flunixin‐cortisol) of the maximal possible responses. Given this information, flunixin may be the best NSAID to use in mitigating castration and tail‐docking pain at the current label dose.
Cost of regulations on US catfish farms
Authors: Hegde Shraddha , Kumar Ganesh , Engle Carole , van Senten Jonathan 
Published: July 2022

AbstractUnderstanding the economic effects of regulations on US aquaculture farms provides insights into which compliance costs create the greatest compliance burden on farms. This can further guide strategies to improve the efficiency of regulatory frameworks and potentially reduce on‐farm compliance costs while maintaining adequate oversight. This study estimated the regulatory compliance burden on US catfish farms as part of a national effort to quantify the cost of regulations on US aquaculture farms. Completed survey interviews of catfish farms in the major catfish‐producing states covered 63% of the total US catfish production area. Total regulatory costs of the US catfish industry were estimated at $45 million annually. Lost farm revenues (measured as the value of lost production, the value of markets lost from regulations, and the value of business opportunities lost because of regulations) were estimated to be $35 million per annum. Catfish‐producing states outside the Alabama/Arkansas/Mississippi region had the highest ($2856/ha) and Alabama the lowest ($1127/ha) regulatory costs per hectare among the surveyed states. The greatest regulatory cost burden on catfish farms ($18 million) was caused by environmental regulations related mostly to the management of federally protected piscivorous migratory birds, followed by labor regulations ($12 million), and taxes/insurance ($7 million). Regulatory costs ($/kg) were 2.6 times higher on smaller (<80 ha) farms relative to larger (>300 ha) farms. Attention is needed to identify alternative regulatory frameworks that provide the same degree of regulatory oversight but are more cost‐efficient.
Comparison of bacterial communities on the surface of concrete breakwater structures and ambient bacterioplankton
Authors: Li K. , Guan W. , He P. , Li K.J. 
Published: July 2022

Abstract
Breakwater structures made of concrete are used widely around the world, and the bacteria living on these surfaces can cause the concrete to deteriorate. In this study, we collected bacterial biofilms from concrete breakwater structures located along the coast of an island, a mainland coast, and a freshwater riverbank as well as planktonic water samples from each site, and we analysed their bacterial community structures using Illumina sequencing. At the phylum level, Proteobacteria and Actinobacteria dominated planktonic samples, whereas Cyanobacteria, Proteobacteria and Bacteroidetes dominated the biofilm samples. High Cyanobacteria abundance was found in all biofilm samples. Bacterial communities significantly varied between planktonic and biofilm samples and between biofilm samples from seawater and freshwater. Only a small number of bacterial operational taxonomic units were shared by planktonic and biofilm samples from each sampling site. The permanganate index in ambient water had a more significant impact on biofilm bacterial communities than on planktonic samples. Additionally, ammonia nitrogen and total nitrogen contents were positively correlated and salinity was negatively correlated with bacterial beta diversity in biofilm samples.
Factors influencing critical care nurses' family engagement practices: An international perspective
Authors: Price Ann M. , McAndrew Natalie S. , Thaqi Qendresa , Kirk Mary , Brysiewicz Petra , Eggenberger Sandra , Naef Rahel 
Published: July 2022

AbstractBackgroundFamily engagement positively impacts patient and family members' experiences of care and health outcomes. While partnering with families denotes best practice in intensive care units (ICUs), its full adoption requires improvement. A better understanding of the factors that influence the implementation of family engagement practices is necessary.AimTo investigate the factors that enable or hinder adult ICU nurse‐family engagement and to explore potential international variations.Study DesignDescriptive, cross‐sectional survey. Nurses from 10 countries completed the ‘Questionnaire on Factors that Influence Family Engagement’ (QFIFE), including five open‐ended questions. We performed descriptive statistics on quantitative data and content analysis for open‐ended questions, and then integrated the findings according to influencing factors and geographical patterns. This was part of a larger qualitative study where 65 nurses participated from adult intensive care units.ResultsSixty‐one nurses completed the questionnaire, making a response rate of 94%. Overall, patient acuity (Md = 5.0) and nurses' attitudes (Md = 4.6) seemed to be the most influential facilitator, followed by nurse workflow (Md = 4.0) and ICU environment (Md = 3.1) (score 1–6 most influential). The open‐ended question data showed a more nuanced picture of the complexity of family engagement in care around these four determinants. Adding a fifth determinant, namely Families are complex structures that respond uniquely to the ICU and patient, revealed that difficult family dynamics, miscommunication and family having difficulty in understanding the situation or health literacy, hindered family engagement. Exploring geographical variations, Africa/Middle East consistently differed from others on three of the four QFIFE subscales, showing lower median levels.ConclusionsSome determinants are perceived to be more influential than others, becoming barriers or enablers to nurse‐family engagement in adult ICU. Research that investigates contextual determinants and which compares implementation and improvement initiatives tailored to address family engagement practices barriers and enablers are needed.Relevance to Clinical PracticeKnowledge of this international study expands our understanding of enablers and barriers in family engagement that may inform family engagement practice improvement efforts around the world.
The carboxy terminal transmembrane domain of SPL7 mediates interaction with RAN1 at the endoplasmic reticulum to regulate ethylene signalling in Arabidopsis
Authors: Yang Yanzhi , Hao Chen , Du Jianmei , Xu Lei , Guo Zhonglong , Li Dong , Cai Huaqing , Guo Hongwei , Li Lei 
Published: July 2022

Summary

In Arabidopsis, copper (Cu) transport to the ethylene receptor ETR1 mediated using RAN1, a Cu transporter located at the endoplasmic reticulum (ER), and Cu homeostasis mediated using SPL7, the key Cu‐responsive transcription factor, are two deeply conserved vital processes. However, whether and how the two processes interact to regulate plant development remain elusive.

We found that its C‐terminal transmembrane domain (TMD) anchors SPL7 to the ER, resulting in dual compartmentalisation of the transcription factor. Immunoprecipitation coupled mass spectrometry, yeast‐two‐hybrid assay, luciferase complementation imaging and subcellular co‐localisation analyses indicate that SPL7 interacts with RAN1 at the ER via the TMD.

Genetic analysis revealed that the ethylene‐induced triple response was significantly compromised in the spl7 mutant, a phenotype rescuable by RAN1 overexpression but not by SPL7 without the TMD. The genetic interaction was corroborated by molecular analysis showing that SPL7 modulates RAN1 abundance in a TMD‐dependent manner. Moreover, SPL7 is feedback regulated by ethylene signalling via EIN3, which binds the SPL7 promoter and represses its transcription.

These results demonstrate that ER‐anchored SPL7 constitutes a cellular mechanism to regulate RAN1 in ethylene signalling and lay the foundation for investigating how Cu homeostasis conditions ethylene sensitivity in the developmental context.
An Improved Multi‐Task Pointwise Network for Segmentation of Building Roofs in Airborne Laser Scanning Point Clouds
Authors: Zhang Chaoquan , Fan Hongchao 
Published: July 2022

AbstractRoof plane segmentation is an essential step in the process of 3D building reconstruction from airborne laser scanning (ALS) point clouds. The existing approaches either rely on human intervention to select the appropriate input parameters for different data‐sets or they are not automatic and efficient. To tackle these issues, an improved multi‐task pointwise network is proposed to simultaneously segment instances (that is, individual roof planes) and semantics (that is, groups of roof planes with similar geometric shapes) in point clouds. PointNet++ is used as a backbone network to extract robust features in the first step. The features from semantics branch are then added to the instance branch to facilitate the learning of instance embeddings. After that, a feature fusion module is added to the semantics branch to acquire more discriminative features from the backbone network. To increase the accuracy of semantic predictions, fused semantic features of the points belonging to the same instance are aggregated together. Finally, a mean‐shift clustering algorithm is employed on instance embeddings to produce the instance predictions. Furthermore, a new roof data‐set (called RoofNTNU) is established by taking ALS point clouds as training data for automatic and more general segmentation. Experiments on the new roof data‐set show that the method achieves promising segmentation results: the mean precision (mPrec) of 96.2% for the instance segmentation task and mean accuracy (mAcc) of 94.4% for the semantic segmentation task.
Why disregarding hypocritical blame is appropriate
Authors: Statman Daniel 
Published: July 2022

AbstractThe topic of standing to blame has recently received a lot of attention. Until now, however, it has focused mainly on the blamer's perspective, investigating what it means to say of blamers that they lose standing to blame and why it is that they lose this standing under specified conditions. The present paper focuses on the perspective of the blamees and tries to explain why they are allowed to disregard standingless, more specifically hypocritical, blame. According to the solution proposed by the paper, while hypocritical blamers present themselves as caring about justice or about the moral or material good of the blamees—and they themselves half‐believe this presentation—their real motivation in blaming is less respectable. It is this problematic motivation that explains why blamees are permitted to disregard hypocritical blame. Ill‐motivated blame is often unreliable, and readiness to even consider it often involves a compromise on the self‐respect of the blamees.
Traveling and Standing Flexural Waves in the Micro-Beam Based on the Fraction-Order Nonlocal Strain Gradient Theory
Authors: Xu Yuqian , Wei Peijun , Huang Yishuang 
Published: July 2022

Abstract
The traveling and standing flexural waves in the microbeam are studied based on the fraction-order nonlocal strain gradient elasticity in the present paper. First, the Hamilton’s variational principle is used to derive the governing equations and the boundary conditions with consideration of both the nonlocal effects and the strain gradient effects. The fraction-order derivative instead of the integer-order derivative is introduced to make the constitutive model more flexible while the integer-order constitutive model can be recovered as a special case. Then, the Euler–Bernoulli beam and the Timoshenko beam are both considered, and the corresponding formulations are derived. Two problems are investigated: (1) the dispersion of traveling flexural waves and the attenuation of the standing waves in the infinite beam and (2) the natural frequency of finite beam. The numerical examples are provided, and the effects of the nonlocal and the strain gradient effects are discussed. The influences of the fraction-order parameters on the wave motion and vibration behavior are mainly studied. It is found that the strain gradient effects and the nonlocal effect have opposite influences on the wave motion and vibration behavior. The fraction order also has evident influence on the wave motion and vibration behavior and thus can refine the prediction of the model.
Satellite Vibration Isolation Using Periodic Acoustic Black Hole Structures With Ultrawide Bandgap
Authors: Lyu Xiaofei , Sheng Hui , He Mengxin , Ding Qian , Tang Lihua , Yang Tianzhi 
Published: July 2022

Abstract
A lightweight whole-spacecraft vibration isolation system with broadband vibration attenuation capability is of great significance to the protection of satellites during the launch phase. The emergence of metamaterials/phononic crystals provides new ideas for the design of such isolation systems. This letter reports a new type of satellite isolation system to isolate shock and vibrations in an ultrawide frequency range. The labyrinth design of this system integrates acoustic black holes (ABHs) as microstructures, which leads to a significant impedance mismatch and enhances the bandgap effect. The ultrawide vibration and shock attenuation ability of the proposed design is confirmed through band structure and transmission analyses as well as the hammer and falling tests, showing the potential for vast isolation applications.