bluuebunny/crossref_metadata_2025_split huggingface dataset:
motivo de la circularidad en espacios inhóspitos en The Circle Game de Margaret Atwood
Authors: Duboué Juan Pablo 
Published: June 2022

El subgénero de la poesía especulativa ha cobrado importancia en las últimas décadas de la mano de la autora canadiense Margaret Atwood (1939) y sus contribuciones a la literatura anglófona tanto en la lírica como en la ficción. En su primer poemario The Circle Game (1964), la autora presenta un uso meticuloso de la distopía, el motivo de la circularidad y las nociones de espacio y lugar que luego son desarrollados a lo largo de toda su obra literaria. En este sentido, el análisis de los poemas principales en The Circle Game se hace necesario para evidenciar el estilo de Margaret Atwood desde su obra más temprana. De esta manera, se logrará contribuir al estudio de los conceptos arriba mencionados, así como también al análisis de obras menos populares de la autora.
Fecha de recepción: 4/11/2020Fecha de aceptación: 11/2/2021

id ark: http://id.caicyt.gov.ar/ark:/s26184141/q4urowkp9
AN ANALYSIS ON THE VIOLATION OF COOPERATIVE PRINCIPLES IN THE FILM AVENGERS
Authors: Wildan Deyana Nika , Rejeki Sari , Taufik M 
Published: June 2022

This research is an analysis on the violation of cooperative principles in the movie Avengers that also describes the type of violation of cooperative principle contained in every conversation in the movie. The research is conducted by using descriptive qualitative method. The subject of this research is the conversation that occurs in the movie Avengers, whilst the object of this research is the data containing forms of every conversation violations of the cooperative principle in the movie Avengers. The technique used in collecting data is called note technique. The data obtained is classified based on the form of violation of cooperative principles. The result of the research shows that the form of violation of the cooperative principle that occurs in the Avengers movie consists of four maxims: the maxim of quantity, the maxim of quality, the maxim of relevance, and the maxim of manner. The violation on the maxim of cooperation occurs because of the same knowledge held by the speech participants and the speech partners in discussing a problem, clarifying information, and changing the subject.Keywords: Violations of cooperative principles, maxim, movie, avengers.
Analisis Penggunaan Kaomoji Pada Kalimat Bahasa Jepang
Authors: Trianto Roby , Fitriana Rina , Karyati Alo 
Published: June 2022

Skripsi ini membahas tentang penggunaan kaomoji pada kalimat bahasa Jepang yang dianalisis secara mendalam berdasarkan tujuan dan fungsinya. Objek penelitian ini adalah salah satu media sosial yakni twitter, dengan memfokuskan kepada satu akun yaitu @Uchida_maaya. Pembahasan dari penelitian ini adalah penyebab kesalahpahaman dalam twitter dalam akun @Uchida_maaya, dan juga akan membahas tentang tujuan dan fungsi apa saja yang sering digunakan oleh Uchida dalam akun twitter-nya tersebut. Penelitian ini menggunakan metode deskriptitf, sumber data pada pembahasan ini diambil dari twitter, buku-buku linguistik, kamus, dan jurnal. Diantaranya: Dasar-Dasar Linguistik Bahasa Jepang, Nonverbal Communication in Human Interaction, Ilmu Komunikasi Suatu Pengantar, Psikologi Komunikasi, Web no Kigou Kaomoji Emoji, The Role of Emoticon in Computer-Mediated Communication. Kesimpulan dari hasil penelitian ini adalah, berdasarkan penelitian Derks Djaante tentang motivasi penggunaan emoticon, tujuan yang paling banyak dipakai oleh Uchida dalam akun twitter-nya adalah mengekspresikan emosi, dan fungsi yang banyak digunakan berdasarkan teori Ekhman adalah sebagai pelengkap.Kata kunci : Kaomoji, Pesan verbal, Pesan Nonverbal
Analisis Sikap Tsundere Tokoh Utama Dalam Drama Hana Yori Dango
Authors: Utami Diah Putri , Fitriana Rina , Mugiyanti Mugiyanti 
Published: June 2022

Abstrak Penelitian ini bertujuan untuk menganalisis unsur intrinsik yang terdapat dalam drama Hana Yori Dango, menganalisis sikap tsundere tokoh utama, serta jenis tsundere tokoh utama dalam drama Hana Yori Dango. Objek penelitian ini adalah drama yang ditayangkan pada tahun 2005 berjudul Hana Yori Dango season 1. Analisis difokuskan pada unsur-unsur intrinsik dengan menggunakan teori Nurgiyantoro. Sedangkan sikap tsundere dan jenis tsundere yang terdapat pada drama tersebut dianalisis menggunakan teori Togashi Junichi, Senko K. Maynard, Patrick W. Galbraith, dan Doan. Adapun metode penelitian yang digunakan adalah metode deskriptif, yaitu metode yang menjabarkan beberapa gambaran dan fakta kemudian menyimpulkannya. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana sikap tsundere pada tokoh utama dan jenis tsundere tokoh utama dalam drama Hana Yori Dango. Penelitian ini mengambil dari berbagai sumber seperti buku-buku, jurnal, dan internet.Kata kunci : Tsundere, sikap, drama.
Compensatory Responses During Slip-Induced Perturbation in Patients With Knee Osteoarthritis Compared With Healthy Older Adults: An Increased Risk of Falls?
Authors: Ren Xiping , Lutter Christoph , Kebbach Maeruan , Bruhn Sven , Yang Qining , Bader Rainer , Tischer Thomas 
Published: June 2022

Background: Functional impairment of the knee joint affected by osteoarthritis and loss of muscle strength leads to a significant increase in the number of falls. Nevertheless, little is known about strategies for coping with gait perturbations in patients with knee osteoarthritis (KOA). Thus, this study aimed to examine the compensatory strategies of patients with KOA in response to a backward slip perturbation compared with healthy older adults.Methods: An automated perturbation program was developed by using D-Flow software based on the Gait Real-time Analysis Interactive Lab, and an induced backward slip perturbation was implemented on nine patients with severe KOA (68.89 ± 3.59 years) and 15 age-matched healthy older adults (68.33 ± 3.29 years). Step length, gait speed, range of motion, vertical ground reaction forces, lower extremity joint angles, and joint moments were computed and analyzed.Results: Compared with older adults, patients with KOA had significantly lower step length, gait speed, and vertical ground reaction forces in both normal walking and the first recovery step following backward slip perturbations. Inadequate flexion and extension of joint angles and insufficient generation of joint moments predispose patients with KOA to fall. Hip extension angle and flexion moment, knee range of motion, and vertical ground reaction forces are key monitoring variables.Conclusion: The risk of falls for patients with KOA in response to backward slip perturbations is higher. Patients with KOA should focus not only on quadriceps muscle strength related to knee range of motion but also on improving hip extensor strength and activation through specific exercises. Targeted resistance training and perturbation-based gait training could be better options.
Greenhouse Gas Emissions From Biofilters for Composting Exhaust Ammonia Removal
Authors: Shang Bin , Zhou Tanlong , Tao Xiuping , Chen Yongxing 
Published: June 2022

Emissions of odorous compounds, such as ammonia (NH3), from composting have negative agronomic and environmental impacts. A biofilter is widely used for NH3 removal, with one of its potential detrimental by-products being nitrous oxide (N2O), which is a higher warming potential greenhouse gas (GHG). The aim of the study was to evaluate the effect of empty bed retention time (EBRT) on GHG emissions from biofilters for removing NH3 from composting. Composting experimental trials lasted 6 weeks, and composting materials were mixtures of dead pigs and manure. Three groups of biofilters with 1.2 m-height, 0.3 m-inner diameter, and 1.0 m media depth were conducted with EBRT of 30, 60, and 100s, respectively. Each treatment was performed in triplicate, and the gas was monitored using the dynamic emission vessel method. The Spearman’s correlation analysis showed a significantly positive correlation between inlet concentrations (ICs) of NH3 and increased N2O concentrations: ρ = 0.707, 0.762, and 0.607 with p ≤ 0.0001 for biofilters with EBRT of 30, 60, and 100s, respectively. The fraction of NH3-N denitrified into N2O-N in biofilters with EBRT of 60 and 100s was higher than that with EBRT of 30s. The total global warming potential (GWP) increased by 126%, 162%, and 144% for biofilters with EBRT of 30, 60, and 100s, respectively. These results indicated that biofilters with longer EBRT will lead to higher GWP production. Future research on odorous mitigation for composting with biofilters should focus more on greenhouse gas emissions.
N6-Methyladenosine Modification Patterns and Tumor Microenvironment Immune Characteristics Associated With Clinical Prognosis Analysis in Stomach Adenocarcinoma
Authors: Meijing Zhang , Tianhang Luo , Biao Yang 
Published: June 2022

Background: N6-methyladenosine (m6A) modification is a part of epigenetic research that has gained increasing attention in recent years. m6A modification is widely involved in many biological behaviors of intracellular RNA by regulating mRNA, thus affecting disease progression and tumor occurrence. However, the effects of m6A modification on immune cell infiltration of the tumor microenvironment (TME) are uncertain in stomach adenocarcinoma (STAD).Methods: The Cancer Genome Map (TCGA) database was used to download transcriptome data, clinicopathological data, and survival data for m6A-regulated genes in 433 STAD tissues that meet the requirements of this study. GSE84437 data were obtained from the Gene Expression Omnibus (GEO) database. The correlation between 23 m6A regulated genes was analyzed using R software. Sample clustering analysis was carried out on the genes of the m6A regulatory factor, and survival analysis and differentiation comparison were made for patients in clustering grouping. Then, the Gene Set Enrichment Analysis (GSEA), the single-sample GSEA (ssGSEA), and other methods were conducted to assess the correlation among m6A modification patterns, TME cell infiltration characteristics, and immune infiltration markers. The m6A modification pattern of individual tumors was quantitatively evaluated using the m6A score scheme of the principal component analysis (PCA).Results: From the TCGA database, 94/433 (21.71%) samples were somatic cell mutations, and ZC3H13 mutations are the most common. Based on the consensus, matrix k-3 is an optimal clustering stability value to identify three different clusters. Three types of m6A methylation modification patterns were significantly different in immune infiltration. Thus, 1028 differentially expressed genes (DEGs) were identified. The survival analysis of the m6A score found that patients in the high m6A score group had a better prognosis than those in the low m6A score group. Further analysis of the survival curve combining tumor mutation burden (TMB) and m6A scores revealed that patients had a significantly lower prognosis in the low tumor mutant group and the low m6A score group (p = 0.003). The results showed that PD-L1 was significantly higher in the high m6A score group than in the low score group (p &lt; 2.22e-16). The high-frequency microsatellite instability (MSI-H) subtype score was significantly different from the other two groups.Conclusions: This study systematically evaluated the modification patterns of 23 m6A regulatory factors in STAD. The m6A modification pattern may be a critical factor leading to inhibitory changes and heterogeneity in TME. This elucidated the TME infiltration characteristics in patients with STAD through the evaluation of the m6A modification pattern.
Plasma Exosome miRNAs Profile in Patients With ST-Segment Elevation Myocardial Infarction
Authors: Guan Ruicong , Zeng Kuan , Zhang Bin , Gao Minnan , Li Jianfen , Jiang Huiqi , Liu Yuqiang , Qiang Yongjia , Liu Zhuxuan , Li Jingwen , Yang Yanqi 
Published: June 2022

BackgroundCirculating microRNAs (miRNAs) have been found to have different expressions in different phases of acute myocardial infarction. The profiles of plasma exosome miRNAs in patients with ST-segment elevation myocardial infarction (STEMI) at 3–6 months postinfarction are unknown.ObjectiveThe aim of this study was to assess the profiles of plasma exosome miRNAs in patients with STEMI in comparison with healthy volunteers and to select specific exosome miRNAs related to pathophysiological changes post-STEMI.MethodsPlasma and echocardiography parameters were collected from 30 patients 3–6 months after STEMI and 30 healthy volunteers. Plasma exosome miRNAs were assessed by using high-throughput sequence (Illumina HiSeq 2500) and profile of the plasma exosome miRNAs was established in 10 patients and 6 healthy volunteers. The specific exosome miRNAs related to heart diseases were selected according to the TargetScan database. The specificity of the selected exosome miRNAs was evaluated in additional 20 post-STEMI patients and 24 healthy volunteers by using quantitative PCR (qPCR). Left ventricular remodeling (LVR) was defined using the European Association of Cardiovascular Imaging criteria according to echocardiography examination. Correlations between expression of the specific miRNAs and echocardiography parameters of LVR were assessed using the Spearman correlation analysis.ResultsTwenty eight upregulated miRNAs and 49 downregulated miRNAs were found in patients 3–6 months after STEMI (p &lt; 0.01) in comparison with the healthy volunteers. The two least expressed and heart-related exosome miRNAs were hsa-miR-181a-3p (0.64-fold, p &lt; 0.01) and hsa-miR-874-3p (0.50-fold, p &lt; 0.01), which were further confirmed by using qPCR and demonstrated significant specificity in another 20 patients with post-STEMI comparing to 24 healthy volunteers [area under the curve (AUC) = 0.68, p &lt; 0.05; AUC = 0.74, p &lt; 0.05]. The expression of hsa-miR-181a-3p was downregulated in patients with LV adverse remodeling in comparison with patients without LV adverse remodeling and healthy volunteers.ConclusionCirculating exosome miR-874-3p and miR-181a-3p were downregulated in patients with STEMI postinfarction. Exosome hsa-miR-181a-3p might play a potential role in the development of LVR in patients with post-STEMI.
Deep Learning for Detection of Exercise-Induced Pulmonary Hypertension Using Chest X-Ray Images
Authors: Kusunose Kenya , Hirata Yukina , Yamaguchi Natsumi , Kosaka Yoshitaka , Tsuji Takumasa , Kotoku Jun’ichi , Sata Masataka 
Published: June 2022

BackgroundStress echocardiography is an emerging tool used to detect exercise-induced pulmonary hypertension (EIPH). However, facilities that can perform stress echocardiography are limited by issues such as cost and equipment.ObjectiveWe evaluated the usefulness of a deep learning (DL) approach based on a chest X-ray (CXR) to predict EIPH in 6-min walk stress echocardiography.MethodsThe study enrolled 142 patients with scleroderma or mixed connective tissue disease with scleroderma features who performed a 6-min walk stress echocardiographic test. EIPH was defined by abnormal cardiac output (CO) responses that involved an increase in mean pulmonary artery pressure (mPAP). We used the previously developed AI model to predict PH and calculated PH probability in this cohort.ResultsEIPH defined as ΔmPAP/ΔCO &gt;3.3 and exercise mPAP &gt;25 mmHg was observed in 52 patients, while non-EIPH was observed in 90 patients. The patients with EIPH had a higher mPAP at rest than those without EIPH. The probability of PH based on the DL model was significantly higher in patients with EIPH than in those without EIPH. Multivariate analysis showed that gender, mean PAP at rest, and the probability of PH based on the DL model were independent predictors of EIPH. A model based on baseline parameters (age, gender, and mPAP at rest) was improved by adding the probability of PH predicted by the DL model (AUC: from 0.65 to 0.74; p = 0.046).ConclusionApplying the DL model based on a CXR may have a potential for detection of EIPH in the clinical setting.
Predictive Factors for Recovery Time in Conceived Women Suffering From Moderate to Severe Ovarian Hyperstimulation Syndrome
Authors: Huang Kai , Shi Ying , Chen Gezi , Shi Hao , Zhai Jun 
Published: June 2022

ObjectiveThis study aimed to evaluate potential predictors for recovery time in pregnant patients with moderate to severe ovarian hyperstimulation syndrome (OHSS).MethodsA total of 424 pregnant patients with moderate to severe OHSS who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) were retrospectively identified. The clinical features and laboratory findings within 24 h after admission were collected. Treatment for OHSS was carried out according to standard procedures, including fluid replacement therapy, human albumin, aspirin, low-molecular-weight heparin, and paracentesis, when necessary. Patients were discharged from the hospital when the tmorning hematocrit was &lt;40% and no obvious clinically relevant symptoms existed, such as abdominal distension, abdominal pain, and shortness of breath. Meanwhile, ultrasound indicating little pleural or abdominal effusion and biochemical abnormalities returning to normal were required. Spearman’s correlation analysis was used to assess the association between the blood-related parameters and recovery time. Multiple linear regression models were used to assess the relationship between the clinical or laboratory parameters and recovery time.ResultsThe median recovery time of these patients was 11 days. In Spearman’s correlation test, leukocytes, hemoglobin, platelets, hematocrit, creatinine, prothrombin time (PT), fibrinogen (Fib), D-dimer, and fibrinogen degradation products (FDPs) were positively correlated with recovery time. On the other hand, albumin and thrombin time (TT) were negatively correlated with recovery time. Multiple linear regression analysis showed that polycystic ovary syndrome (PCOS), hemoglobin, platelets, albumin, and Fib were significantly associated with the recovery time of patients with OHSS (p = 0.023, p &lt; 0.001, p = 0.007, p &lt; 0.001, and p = 0.019, respectively).ConclusionsIn pregnant patients with OHSS, PCOS and hypoalbuminemia were associated with a significantly longer recovery time. Meanwhile, the recovery time was longer when patients have high levels of hemoglobin, platelets, and Fib.
HCG Trigger of GnRH Agonist-Induced Functional Ovarian Cysts Does Not Decrease Clinical Pregnancy Rate in GnRHa Pretreated Frozen Cycles: Evidence From a Retrospective Cohort Study
Authors: Zeng Hong , Zhang Chen , Zhang Lei , Liu Nenghui 
Published: June 2022

BackgroundGnRH agonist (GnRHa) pretreatment before the frozen-thawed embryo transfer (FET) was increasingly utilized. However, the incidence of GnRHa-induced functional ovarian cysts (FC) was inevitable. The feasibility and efficacy of HCG triggering GnRHa-induced FC are unknown.ObjectiveThe aim of the study was to investigate the effect of HCG triggering GnRHa-induced FC on FET outcomes.MethodsA total of 657 HRT-FET cycles with GnRHa pretreatment were retrospectively analyzed. Patients were divided into the FC group and the no functional cysts (NC) group according to whether the patient developed FC (follicular diameter of ≥7 mm and E2 of ≥100 pg/ml). Risk factors associated with the incidence of GnRHa-induced FC were determined by multivariate regression analysis. Pregnancy outcomes were compared between the FC group and the NC group. Propensity score matching (PSM) was performed to reduce the impact of confounding factors. Three multivariate regression models were performed to assess the association between HCG triggering GnRHa-induced FC and clinical pregnancy. Interactive analysis and subgroup analysis were also analyzed.ResultsThe incidence rate of GnRHa-induced FC was 9.74%. Older age (aOR 1.10, 95% CI 1.05-1.15, p-value &lt; 0.001) and lower BMI (aOR 0.81, 95% CI 0.71-0.93, p-value=0.002) are risk factors for GnRHa-induced FC. The implantation rate, clinical pregnancy rate (CPR), and miscarriage rate were not significantly different between the FC group and the NC group before or after PSM (p-value &gt; 0.05). Multivariate logistic models showed that HCG triggering GnRHa-induced FC does not decrease CPR in the general population (p-value &gt; 0.05). The effect of HCG triggering GnRHa-induced FC on clinical pregnancy is interactive with age (p-value for interaction: 0.003); HCG trigger is associated with significantly higher CPR than HRT-FET cycles without FC in patients ≥35 years (aOR 4.40, 95% CI 1.57–12.3, p-value = 0.005).ConclusionsHCG triggering GnRHa-induced FC does not decrease the chance of clinical pregnancy in HRT-FET cycles pretreated with GnRHa.
Effects of Berberine Plus Inulin on Diabetes Care in Patients With Latent Autoimmune Diabetes in Adults: Protocol for a Randomized Controlled Trial
Authors: Zhang Rong , Xiao Yang , Yan Jianru , Yang Wen , Wu Xiaomei , Mei Zubing , Zhou Zhiguang 
Published: June 2022

BackgroundLatent autoimmune diabetes in adults (LADA) is a heterogeneous form of diabetes, characterized by autoimmune destruction of pancreatic β-cells as well as insulin resistance and is triggered by environmental factors in the context of genetic susceptibility. Berberine (BBR), a small alkaloid isolated from medicinal plants, has antidiabetic, anti-inflammatory, and antibacterial effects. Inulin is a common prebiotic that has been shown to improve glycemic control, alter the gut microbiota and suppress inflammation. The primary purpose of this study was to evaluate the effects of oral BBR and inulin combined with insulin therapy on diabetes care in patients with LADA.Methods and AnalysisWe will conduct a single-center, prospective, randomized, double-blind, placebo-controlled trial. A total of 240 patients with LADA who have started insulin therapy will be randomly allocated either to the intervention or control group. After a 1-week run-in period, they will complete a 3-month treatment of BBR alone, inulin plus BBR, inulin alone, or placebo. Anthropometric and clinical data will be collected at five time points: baseline, 3 months, 6 months, 9 months, and 12 months from baseline. The primary outcome was the change in glycated hemoglobin levels. Dynamic blood glucose parameters, β-cell function, and gut microbiota, as well as adverse events and quality of life will be monitored.DiscussionGlycemic control is critical for preventing the progression of diabetes. Although insulin is a recommended treatment for patients with LADA, there are currently no drugs that can effectively prevent the progressive destruction of pancreatic β-cells or maintain their function. Several studies have found that when berberine and prebiotics are used alone, they have beneficial metabolic effects. This clinical research protocol will assess the efficacy of the combined treatment of berberine plus inulin and provide new ideas for future pharmacological research and clinical practices in diabetes care and glycemic control for LADA patients.Ethics and DisseminationThis study has been approved by the Ethics Committee of National Clinical Research Center of the Second Xiangya Hospital of Central South University (approval number: 2021–046).Clinical Trial RegistrationClinicalTrials.gov, identifier NCT04698330