bluuebunny/crossref_metadata_2025_split huggingface dataset:
The C-ORAL-ESQ project: a corpus for the study of spontaneous speech of individuals with schizophrenia
Authors: Raso Tommaso , Rocha Bruno Neves Rati de Melo , Salgado João Vinícius , Cruz Breno Fiuza , Mantovani Lucas Machado , Mello Heliana 
Published: September 2022

Abstract
This paper presents the C-ORAL-ESQ corpus project, which is dedicated to the study of the speech of individuals with schizophrenia. The main aim of the project is to investigate cognitive aspects of individuals with schizophrenia. This investigation is carried through the compilation of a spontaneous speech corpus and its study, which focuses mainly on the analysis of information structuring and its prosodic correlates. The paper informs about the environment and the setting of the sound file recordings, the medical and ethical criteria for the selection of the participants, the corpus aimed dimensions and the present stage of compilation, as well as its design and compilation criteria, which include attention to prosodic annotation, and metadata related to the participants’ characteristics. Additionally, the theory adopted for the study of information structure is summarized, focusing on those aspects that can better address cognitive processes of individuals with schizophrenia and their prosodic correlates. Finally, the perspectives for future studies and resource compilations are presented.
Characterization of three pheromones (α-Bergamotol , β-farnesene, Isobombykol) from Saussurea costus essential oil by Gas chromatography/mass spectrometry
Authors: MELIANI Amina , Nair Samira , Djadouni Fatima 
Published: September 2022

Abstract
With the need of sustainable agroecosystem, pest management is becoming imperative. Nowadays, it is known that essential oils are potent molecules with high potential for plant protection. These advantages have encouraged scientists to intensively screen for the plants biomolecules as promising candidates for pest management to replace currently used chemical pesticides. The application of such as technology for the removal of these insects has received much attention and led to the development of effective, economic and environmentally friendly technologies. In this study, a metabolomic approach was used to investigate the characterization of three pheromones, identified by gas chromatography-mass spectrometry (GC-MS) as α-Bergamotol, β-farnesene, Isobombykol.
The preoperative lymphocyte ratio and postoperative C-reactive protein are related to the surgical outcome in biliary atresia: An analysis of serial ubiquitous markers of inflammation
Authors: Harumatsu Toshio , Muraji Toshihiro , Sugita Koshiro , Murakami Masakazu , Yano Keisuke , Onishi Shun , Yamada Koji , Yamada Waka , Matsukubo Makoto , Kawano Takafumi , Muto Mitsuru , Kaji Tatsuru , Ieiri Satoshi 
Published: September 2022

Abstract
Purpose: Various prognostic predictors for biliary atresia (BA) have been identified. This study aimed to evaluate the serial changes in the preoperative and postoperative ubiquitous inflammatory biomarkers and their relationship with the outcomes in patients with BA.
Patients and Methods: Forty-three BA patients were retrospectively reviewed to investigate serial levels of ubiquitous inflammatory biomarkers, including C-reactive protein (CRP) and lymphocyte ratio, and outcomes. The patients with BA were divided based on their outcomes into two prognostic groups: the native liver survivor group (n=30) and the survivors with living-donor liver transplant group (n=13).
Results: The area under the receiver operating characteristic (ROC) curve analysis showed that a preoperative lymphocyte ratio of <61% and CRP value >0.1 mg/dl predicted a poor outcome. In the ROC curve analysis, the timing of reaching the cut-off value of CRP after Kasai portoenterostomy was postoperative day (POD) 57. The third postoperative week, which was the timing of the discontinuation of steroid therapy, was the branchpoint of inflammatory markers between the two prognostic groups.
Conclusion: The POD 57 CRP level predicts the surgical outcome of Kasai portoenterostomy. The postoperative anti-inflammatory management of BA can be monitored by the ubiquitous inflammatory biomarkers CRP and the preoperative lymphocyte ratio.
Effects of nitrogen additions on greenhouse gas fluxes during continuous freeze-thaw cycles in a cold temperate forest
Authors: Wang Shijia , Cui Xiaoyang , Guo Yafen 
Published: September 2022

Abstract
Either nitrogen (N) deposition or soil freeze-thaw cycles (FTCs) induce a pulse of greenhouse gas (GHG) in the cold temperate zone caused by changes in soil carbon (C) and N substrates turnover. However, the synthetic effects between N additions and FTCs to GHG fluxes have received little attention in experiments, particularly in the boreal forest. We conducted a laboratory incubation using intact soil cores from Rhododendron dauricum-Larix dahurica to investigate GHG fluxes that responded to the combined effects. We separated the soil samples into seven groups—none, low, medium, and high sodium nitrate addition, and low, medium, and high ammonium chloride addition—and exposed each group to continuous FTCs conditions. The results demonstrated that N2O and CO2 emissions were eventually stimulated by FTCs, while CH4 uptake was inhibited by FTCs, but they manifested themselves differently under different N addition treatments. All treatments resulted in substantial increases in N2O emissions compared to the control. However, the soil respiration rate increased significantly only with medium sodium nitrate addition, and high N level additions inhibited CH4 uptake regardless of N form. These findings demonstrate that FTCs and N additions, including various N forms and levels, have a considerable effect on GHG emissions in temperate forest ecosystems, which is necessary to predict future feedback effects of GHG emissions on climate change.
Spatial distribution of total petroleum hydrocarbons in the seawater and sediment of Southeast coast of India
Authors: Barathkumar S , Savurirajan M , Raja P , Marigoudar S. R , Sharma K. V , Murthy M. V Ramana 
Published: September 2022

Abstract
The spatial distribution of Total Petroleum Hydrocarbons (TPH) were analyzed in the seawater and sediment samples collected from 27 locations along the Southeast coast of India. A first-time assessment study was carried out on the distribution of TPH in both water and sediments for the entire coastline of Tamil Nadu. The concentration of TPH in seawater showed large spatial variation ranging from Below Detection Level (BDL) to 47.5μg/L and 0.01 to 53.12μg/L in the surface and bottom waters, respectively. TPH levels exceeded the regulatory limits specified by FAO, China's Marine Monitoring Standards and the European Community in the seawater samples of Thoothukudi harbour (S2 station). TPH values in sediment were between 2.33-30.07μg/g and their levels remained below the Marine Sediment Quality Standard (500μg/g). The results showed that seawaters of southern stations were comparatively more polluted with TPH. The spatial profile of TPH in sediments were contrasting to that observed for seawater. Higher TPH values were observed in the northern region than southern. TPH contents showed affinity to clay and silt with a strong positive correlation with clay (R2=0.776; P<0.001), silt (R2=0.648; P<0.001) and negative correlation (R2=0.753; P<0.001) with sand. ANOVA analysis demonstrated a significant difference (F=11.75; p<0.01) between the TPH concentrations of water and sediments. Non-metric multidimensional scaling (nMDS) was performed to determine the similarity among sampling stations that formed five crusted groups. Sediment along the southeast coast can be categorised as slightly polluted with respect to TPH as per the ATSDR standards.
Laboratory and semi-field efficacy evaluation of permethrin-piperonyl butoxide treated blankets against pyrethroid-resistant malaria vectors
Authors: Azizi Salum , Matowo Johnson , Mbewe Njelembo Joshua , Protopopoff Natacha , Athumani Rashid , Matiku Wambura , Shayo Magreth , Tenu Filemoni , Rowland Mark , Mosha Franklin , Kitau Jovin 
Published: September 2022

Abstract
To control pyrethroid-resistant malaria vectors, Indoor Residual Spraying (IRS) and Long-Lasting Insecticidal Nets (LLINs) that include additional active ingredients to pyrethroid are being developed. Same progress needs to be made to the pyrethroid-treated blankets, which are more compatible with shelter structures found in emergency settings such as displaced populations. In the current study, efficacy of blankets treated with permethrin and piperonyl butoxide (PBO) was evaluated against pyrethroid-resistant Anopheles gambiae sensu stricto. Efficacy was compared with that of new Olyset® LLIN, Olyset™ Plus LLIN and untreated blanket in terms of mortality and blood-feeding inhibition against pyrethroid-resistant Anopheles gambiae mosquitoes. The current study indicates that, in emergency shelters such as migrant and refugee camps where LLINs cannot be used, permethrin-PBO blankets may provide protection against resistant mosquitoes if widely used. No side effects related to the use of the treated blankets were reported from the participants. These results need validation in a large-scale field trial to assess the epidemiological impact of the intervention, durability and acceptability of this new vector control strategy for malaria vector control.
Shell disc beads and the development of class-based society at the K2-Mapungubwe settlement complex (South Africa)
Authors: Mouton Michelle , Antonites Alexander 
Published: September 2022

Abstract
The K2-Mapungubwe settlement complex is widely regarded as the centre for the development of class-based society out of earlier ranked communities between c. AD 900 – AD 1300 in northern south Africa, southern Zimbabwe and eastern Botswana. Beads made from ostrich eggs, and the shells of Achatinidae snails, and freshwater bivalves, formed an important part of the K2-Mapungubwe economy. Although thousands of shell beads have been excavated at the K2-Mapugubwe complex, this assemblage have never been analysed or even quantified in any meaningful manner. As such, only rough estimates of the distribution, use and meaning of shell beads at these important sites. This article represents the first focussed research effort on this assemblage. The results demonstrate distinct spatial and chronological changes in the shell bead assemblage were discerned. Chronologically, Achatina beads are more common earlier in earlier phases but after AD 1220, ostrich eggshell beads dominate all assemblages. This could indicate access to new sources of raw materials. Morphology of beads assemblages are also linked to distinct social scales of consumption. The shell bead assemblage from higher status areas remained constant over time, with a clear preference for smaller sized beads. In contrast, beads from the lower status areas could be grouped into distinct clusters of larger and smaller beads. The grouping of smaller bead on lower status areas closely resemble elite assemblages. Smaller beads however become proportionally rarer outside elite areas over time. This may reflect changes in elite control and preferential access to shell beads. These results demonstrate how the use and manufacture of shell beads intersected with the socio-political changes that characterise the period. It also highlights the need for careful consideration of shell beads as a significant component of the political economy in the southern African Iron Age.
The Effect of Submeso Motions on the Budgets of the Mean Turbulent Kinetic Energy and Temperature Variance in the Stable Atmospheric Surface Layer
Authors: Schiavon Mario , Tampieri Francesco , Caggio Matteo , Mazzola Mauro , Viola Angelo Pietro 
Published: September 2022

Abstract
By considering turbulence observations in the atmospheric stable surface layer over complex terrain, we study the effect of submeso motions on the budgets of the mean turbulent kinetic energy (TKE) and (half) the temperature variance. Different averaging times are considered (i.e., 100 s and 30 min), to filter out or retain the submeso contributions to second-order moments. Furthermore, results are interpreted by introducing four parameters that express the relative submeso contribution to the TKE, the temperature variance, and the vertical fluxes of heat and momentum. Four regimes are identified according to these four submeso parameters and the budgets are evaluated for these regimes. A balance among production, buoyancy (for the TKE) and dissipation occurs for the two regimes characterized by small submeso contribution to the fluxes; whilst an unbalance occurs for the other two regimes, where the submeso contribution to the fluxes is large. Instead, the budgets are independent of the magnitude of the submeso contribution to the TKE and the temperature variance.
Receptor-like cytoplasmic kinase STK confers salt tolerance in rice
Authors: Zhou Yanbiao , Zhang Zhihui , Zhao Xinhui , Liu Lan , Tang Qianying , Fu Jun , Tang Xiaodan , Yang Runqiu , Lin Jianzhong , Liu Xuanming , Yang Yuanzhu 
Published: September 2022

Abstract
Background
Soil salinization is a major abiotic environmental stress factor threatening crop production throughout the world. Salt stress drastically affects the growth, development, and grain yield of rice (Oryza sativa L.), and the improvement of rice tolerance to salt stress is a desirable approach for meeting increasing food demand. Receptor-like cytoplasmic kinases (RLCKs) play essential roles in plant growth, development and responses to environmental stresses. However, little is known about their functions in salt stress. Previous reports have demonstrated that overexpression of an RLCK gene STK enhances salt tolerance in rice, and that STK may regulate the expression of GST (Glutathione S-transferase) genes.
Results
The expression of STK is rapidly induced by ABA. STK was mainly expressed in shoot and stem at the seedling and heading stage, respectively. STK was localized at the plasma membrane. Overexpression of STK in rice increased tolerance to salt stress and oxidative stress by increasing ROS scavenging ability and ABA sensitivity. In contrast, CRISPR/Cas9-mediated knockout of STK increased the sensitivity of rice to salt stress and oxidative stress. Transcriptome sequencing analysis suggested that STK increased the expression of GST genes (LOC_Os03g17480, LOC_Os10g38140 and LOC_Os10g38710) under salt stress. Quantitative real time RT-PCR suggested that four stress-related genes may be regulated by STK including OsABAR1, Os3BGlu6, OSBZ8 and OsSIK1.
Conclusions
These findings suggest that STK plays a positive regulatory role in salt stress tolerance by inducing antioxidant defense and associated with the ABA signaling pathway in rice.
Prevalence and Risk Factors for Ototoxicity After Cisplatin-based Chemotherapy
Authors: Sanchez Victoria A. , Dinh Paul C. , Rooker Jennessa , Monahan Patrick O. , Althouse Sandra K. , Fung Chunkit , Sesso Howard D. , Einhorn Lawrence H. , Dolan M. Eileen , Frisina Robert D. , Travis Lois B. 
Published: September 2022

Abstract
PURPOSE
Ototoxicity is a prominent side effect of cisplatin-based chemotherapy. There are few reports, however, estimating its prevalence in well-defined cohorts and associated risk-factors.
METHODS
Testicular cancer (TC) survivors given first-line cisplatin-based chemotherapy completed validated questionnaires. Descriptive statistics evaluated ototoxicity prevalence. We compared patients with and without tinnitus or hearing loss using Chi-square test, two-sided Fisher's Exact test, or two-sided Wilcoxon Rank Sum test. To evaluate ototoxicity risk factors, a backward selection logistic regression procedure was performed.
RESULTS
Of 145 TC survivors, 74% reported ototoxicity: 68%-tinnitus; 59% hearing loss; and 52% reported both. TC survivors with tinnitus were more likely to indicate hypercholesterolemia (P=0.008), and difficulty hearing (P<.001). Tinnitus was also significantly related to age at survey-completion (OR=1.79; P=0.003) and cumulative cisplatin dose (OR=5.17; P<0.001). TC survivors with hearing loss were more likely to report diabetes (P=0.042), hypertension (P=0.007), hypercholesterolemia (P<0.001), and family-history of hearing loss (P=0.044). Risk factors for hearing loss included age at survey-completion (OR=1.57; P=0.036), hypercholesterolemia (OR=3.45; P=0.007), cumulative cisplatin dose (OR=1.94; P=0.049), and family history of hearing loss (OR=2.87; P=0.071).
CONCLUSIONS
Ototoxicity risk factors included age, cisplatin dose, cardiovascular risk factors, and family-history of hearing loss. Three of four TC survivors report some type of ototoxicity; thus, follow-up of cisplatin-treated survivors should include routine assessment for ototoxicity with provision of indicated treatments.
IMPLICATIONS FOR CANCER SURVIVORS
Survivors should be aware of risk factors associated with ototoxicity. Referrals to audiologists before, during, and after cisplatin treatment is recommended.
Sex differences in the inflammatory response of the mouse DRG and its connection to pain in experimental autoimmune encephalomyelitis.
Authors: Maguire Aislinn D , Friedman Timothy N , Andrade Dania N Villarreal , Haq Fajr , Dunn Jacob , Pfeifle Keiana , Tenorio Gustavo , Buro Karen , Plemel Jason R , Kerr Bradley J 
Published: September 2022

Abstract
Multiple Sclerosis (MS) is an autoimmune disease with notable sex differences. Women are not only more likely to develop MS but are also more likely than men to experience neuropathic pain in the disease. It has been postulated that neuropathic pain in MS can originate in the peripheral nervous system at the level of the dorsal root ganglia (DRG), which houses primary pain sensing neurons (nociceptors). These nociceptors become hyperexcitable in response to inflammation, leading to peripheral sensitization and eventually central sensitization, which maintains pain long-term. The mouse model experimental autoimmune encephalomyelitis (EAE) is a good model for human MS as it replicates classic MS symptoms including pain. Using EAE mice as well as primary mouse DRG neurons cultured in vitro, we sought to characterize the sex differences specifically in peripheral sensory neurons. We found sex differences in the inflammatory profile of the EAE DRG, and in the TNFα downstream signaling pathways activated intracellularly in cultured nociceptors. Given that TNFα signaling has been shown to impact on mitochondrial function, this led us to investigate sex differences in the mitochondria’s response to TNFα. Our results demonstrate that male sensory neurons are more sensitive to mitochondrial stress, making them prone to neuronal injury. In contrast, female sensory neurons appear to be more resistant to mitochondrial stress and exhibit an inflammatory and regenerative phenotype that may underlie greater nociceptor hyperexcitability and pain. Understanding these sex differences at the level of the primary sensory neuron is an important first step in our eventual goal of developing sex-specific treatments to halt pain development in the periphery before central sensitization is established.
Seismic Performance Evaluation of Masonry Infill R.C. Frame Considering Soil-Structure Interaction
Authors: Pyakurel Shuvam , Karki Prajwol , Utkarsh Kumar 
Published: September 2022

Abstract
The structural damage due to recent seismic events in Nepal has led to a dire need for studies considering soil-structure interaction (SSI) as the majority of designers still adopt conventional design principles. These damages may be the result of the conventional fixed base method’s failure to take into account the underlying soil properties. Post Mw 7.8 Gorkha earthquake, revised Nepal National Building code NNBC 105:2020 has classified soil types based on the rigidity of the soil. A comparative analysis is carried out using linear-static and non-linear static (Pushover) analysis considering the fixed and flexible base of a masonry infill RC frame. The seismic performance parameter evaluated for a target inelastic drift of 2% are in terms of their fundamental time period, peak floor displacement, inter-storey drift ratio (IDR), ultimate load carrying capacity and yield mechanism. The consideration of SSI drastically influenced the fundamental time period, peak floor displacement and IDR with decreasing rigidity of soil. The fixed base structure exhibited a higher ultimate load-carrying capacity than the flexible base structure for all soil types. The masonry infill dissipated the seismic energy by the failure of the majority of struts. Furthermore, the post-yield behaviour of all models highlighted that the damage level of RC frame and masonry infill elements were higher for fixed base.
A novel inverse membrane bioreactor for efficient bioconversion from methane gas to liquid methanol using a microbial gas-phase reaction
Authors: Chen Yan-Yu , Ishikawa Masahito , Hori Katsutoshi 
Published: September 2022

Abstract
Background
Methane (CH4), as one of the major energy sources, easily escapes from the supply chain into the atmosphere because it exists in a gaseous state under ambient conditions. Compared to carbon dioxide (CO2), CH4 is 25 times more potent at trapping radiation; thus, the emission of CH4 to the atmosphere causes severe global warming and climate change. To mitigate CH4 emissions and utilize them effectively, the direct biological conversion of CH4 into liquid fuels, such as methanol (CH3OH), using methanotrophs is a promising strategy. However, supplying biocatalysts in an aqueous medium with CH4 involves high energy consumption due to vigorous agitation and/or bubbling, which is a serious concern in methanotrophic processes, because the aqueous phase causes a very large barrier to the delivery of slightly soluble gases.
Results
An inverse membrane bioreactor (IMBR), which combines the advantages of gas-phase bioreactors and membrane bioreactors, was designed and constructed for the bioconversion of CH4 into CH3OH in this study. In contrast to the conventional membrane bioreactor with biofilms that are immersed in an aqueous phase, the biofilm in the IMBR was placed to face a gas phase to supply CH4 directly from the gas phase to bacterial cells. Methylococcus capsulatus (Bath), a representative methanotroph, was used to demonstrate the bioconversion of CH4 to CH3OH in the IMBR. Cyclopropanol and sodium formate were supplied from the aqueous phase as a selective inhibitor of methanol dehydrogenase, preventing further CH3OH oxidation, and as an electron donor, respectively. After optimizing the inlet concentration of CH4, the mass of immobilized cells, the cyclopropanol concentration, and the gas flow rate, continuous CH3OH production can be achieved over 72 h with productivity at 0.88 mmol L-1 h-1 in the IMBR, achieving a longer operation period and higher productivity than those using other types of membrane bioreactors reported in the literature.
Conclusions
The IMBR can facilitate the development of gas-to-liquid (GTL) technologies via microbial processes, allowing highly efficient mass transfer of substrates from the gas phase to microbial cells in the gas phase and having the supplement of soluble chemicals convenient.