bluuebunny/crossref_metadata_2025_split huggingface dataset:
Only virgin type of olive oil consumption reduces the risk of mortality. Results from a Mediterranean population-based cohort
Authors: Donat-Vargas Carolina , Lopez-Garcia Esther , Banegas José R. , Martínez-González Miguel Á. , Rodríguez-Artalejo Fernando , Guallar-Castillón Pilar 
Published: October 2022

Abstract
Background
Evidence on the association between virgin olive oil (OO) and mortality is limited since no attempt has previously been made to discern about main OO varieties.

Objective
We examined the association between OO consumption (differentiating by common and virgin varieties) and total as well as cause-specific long-term mortality

Methods
12,161 individuals, representative of the Spanish population ≥18 years old, were recruited between 2008 and 2010 and followed up through 2019. Habitual food consumption was collected at baseline with a validated computerized dietary history. The association between tertiles of OO main varieties and all-cause, cardiovascular and cancer mortality were analyzed using Cox models.

Results
After a mean follow-up of 10.7 years (129,272 person-years), 143 cardiovascular deaths, and 146 cancer deaths occurred. The hazard ratio (HR) (95% confidence interval) for all-cause mortality in the highest tertile of common and virgin OO consumption were 0.96 (0.75–1.23; P-trend 0.891) and 0.66 (0.49–0.90; P-trend 0.040). The HR for all-cause mortality per a 10 g/day increase in virgin OO was 0.91 (0.83–1.00). Virgin OO consumption was also inversely associated with cardiovascular mortality, with a HR of 0.43 (0.20–0.91; P-trend 0.017), but common OO was not, with a HR of 0.88 (0.49–1.60; P-trend 0.242). No variety of OO was associated with cancer mortality.

Conclusion
Daily moderate consumption of virgin OO (1 and 1/2 tablespoons) was associated with a one-third lower risk of all-cause as well as half the risk of cardiovascular mortality. These effects were not seen for common OO. These findings may be useful to reappraise dietary guidelines.
Disentangling nigral and putaminal contribution to motor impairment and levodopa response in Parkinson’s disease
Authors: Schröter Nils , Rijntjes Michel , Urbach Horst , Weiller Cornelius , Treppner Martin , Kellner Elias , Jost Wolfgang H. , Sajonz Bastian E. A. , Reisert Marco , Hosp Jonas A. , Rau Alexander 
Published: October 2022

AbstractThe extent to which the degeneration of the substantia nigra (SN) and putamen each contribute to motor impairment in Parkinson’s disease (PD) is unclear, as they are usually investigated using different imaging modalities. To examine the pathophysiological significance of the SN and putamen in both motor impairment and the levodopa response in PD using diffusion microstructure imaging (DMI). In this monocentric retrospective cross-sectional study, DMI parameters from 108 patients with PD and 35 healthy controls (HC) were analyzed using a voxel- and region-based approach. Linear models were applied to investigate the association between individual DMI parameters and Movement Disorder Society Unified Parkinson’s Disease Rating Scale-Part 3 performance in ON- and OFF-states, as well as the levodopa response, controlling for age and sex. Voxel- and region-based group comparisons of DMI parameters between PD and HC revealed significant differences in the SN and putamen. In PD, a poorer MDS-UPDRS-III performance in the ON-state was associated with increased free fluid in the SN (b-weight = 65.79, p = 0.004) and putamen (b-weight = 86.00, p = 0.006), and contrariwise with the demise of cells in both structures. The levodopa response was inversely associated with free fluid both in the SN (b-weight = −83.61, p = 0.009) and putamen (b-weight = −176.56, p < 0.001). Interestingly, when the two structures were assessed together, the integrity of the putamen, but not the SN, served as a predictor for the levodopa response (b-weight = −158.03, p < 0.001). Structural alterations in the SN and putamen can be measured by diffusion microstructure imaging in PD. They are associated with poorer motor performance in the ON-state, as well as a reduced response to levodopa. While both nigral and putaminal integrity are required for good performance in the ON-state, it is putaminal integrity alone that determines the levodopa response. Therefore, the structural integrity of the putamen is crucial for the improvement of motor symptoms to dopaminergic medication, and might therefore serve as a promising biomarker for motor staging.
Early dynamics of chronic myeloid leukemia on nilotinib predicts deep molecular response
Authors: Okamoto Yuji , Hirano Mitsuhito , Morino Kai , Kajita Masashi K. , Nakaoka Shinji , Tsuda Mayuko , Sugimoto Kei-ji , Tamaki Shigehisa , Hisatake Junichi , Yokoyama Hisayuki , Igarashi Tadahiko , Shinagawa Atsushi , Sugawara Takeaki , Hara Satoru , Fujikawa Kazuhisa , Shimizu Seiichi , Yujiri Toshiaki , Wakita Hisashi , Nishiwaki Kaichi , Tojo Arinobu , Aihara Kazuyuki 
Published: October 2022

AbstractChronic myeloid leukemia (CML) is a myeloproliferative disorder caused by the BCR-ABL1 tyrosine kinase. Although ABL1-specific tyrosine kinase inhibitors (TKIs) including nilotinib have dramatically improved the prognosis of patients with CML, the TKI efficacy depends on the individual patient. In this work, we found that the patients with different nilotinib responses can be classified by using the estimated parameters of our simple dynamical model with two common laboratory findings. Furthermore, our proposed method identified patients who failed to achieve a treatment goal with high fidelity according to the data collected only at three initial time points during nilotinib therapy. Since our model relies on the general properties of TKI response, our framework would be applicable to CML patients who receive frontline nilotinib or other TKIs.
Optical mapping compendium of structural variants across global cattle breeds
Authors: Talenti A. , Powell J. , Wragg D. , Chepkwony M. , Fisch A. , Ferreira B. R. , Mercadante M. E. Z. , Santos I. M. , Ezeasor C. K. , Obishakin E. T. , Muhanguzi D. , Amanyire W. , Silwamba I. , Muma J. B. , Mainda G. , Kelly R. F. , Toye P. , Connelley T. , Prendergast J. 
Published: October 2022

AbstractStructural variants (SV) have been linked to important bovine disease phenotypes, but due to the difficulty of their accurate detection with standard sequencing approaches, their role in shaping important traits across cattle breeds is largely unexplored. Optical mapping is an alternative approach for mapping SVs that has been shown to have higher sensitivity than DNA sequencing approaches. The aim of this project was to use optical mapping to develop a high-quality database of structural variation across cattle breeds from different geographical regions, to enable further study of SVs in cattle. To do this we generated 100X Bionano optical mapping data for 18 cattle of nine different ancestries, three continents and both cattle sub-species. In total we identified 13,457 SVs, of which 1,200 putatively overlap coding regions. This resource provides a high-quality set of optical mapping-based SV calls that can be used across studies, from validating DNA sequencing-based SV calls to prioritising candidate functional variants in genetic association studies and expanding our understanding of the role of SVs in cattle evolution.
A detailed behavioral, videographic, and neural dataset on object recognition in mice
Authors: Rodgers Chris C. 
Published: October 2022

AbstractMice adeptly use their whiskers to touch, recognize, and learn about objects in their environment. This behavior is enabled by computations performed by populations of neurons in the somatosensory cortex. To understand these computations, we trained mice to use their whiskers to recognize different shapes while we recorded activity in the barrel cortex, which processes whisker input. Here, we present a large dataset of high-speed video of the whiskers, along with rigorous tracking of the entire extent of multiple whiskers and every contact they made on the shape. We used spike sorting to identify individual neurons, which responded with precise timing to whisker contacts and motion. These data will be useful for understanding the behavioral strategies mice use to explore objects, as well as the neuronal dynamics that mediate those strategies. In addition, our carefully curated labeled data could be used to develop new computer vision algorithms for tracking body posture, or for extracting responses of individual neurons from large-scale neural recordings.
A CBCT based cross sectional study on the prevalence and anatomical feature of C shaped molar among Jordanian
Authors: Al Omari Taher , AlKhader Mustafa , Ateş Ayfer Atav , Wahjuningrum Dian Agustin , Dkmak Alaa , Khaled Waheeb , Alzenate Hazem 
Published: October 2022

AbstractThe prevalence and anatomical features of C-Shaped Mandibular Second Molars (MSMs) are rarely studied in Jordanian sub-population. This study then took a part to evaluate the prevalence of C-shaped in MSMs using cone-beam computed tomography (CBCT) in the Jordanian sub-population. It used a cross-sectional design and three thousand scans collected over eight years between 2011 and 2019. The data were then reviewed for whether they were fully formed of MSMs. A total of 2037 cases that had 2845 MSMs were evaluated to identify C-shaped canals at coronal, middle, and apical sites. An oblique slicing module perpendicular to the long axis of MSMs was used to evaluate the teeth. The type and frequency of C-shaped canals, as well as the correlations between sex and side (right/left) and between sex and groove direction (buccal/lingual) were measured using the chi-square test on SPSS software at the significance level of 95%. A total of 342 teeth of 243 patients were C-shaped molars, which comprised 12% of the patient’s teeth and 99 of them as a bilateral C-shaped canal with mean age of 40 years and sex ratio of 2:1 between female and male. With the limitations of this study, the lingual groove and type 3 were the most common properties of MSM. Besides, the Jordanian population mostly had C-shaped canals.
Integrated network-based multiple computational analyses for identification of co-expressed candidate genes associated with neurological manifestations of COVID-19
Authors: Hazra Suvojit , Chaudhuri Alok Ghosh , Tiwary Basant K. , Chakrabarti Nilkanta 
Published: October 2022

Abstract‘Tripartite network’ (TN) and ‘combined gene network’ (CGN) were constructed and their hub-bottleneck and driver nodes (44 genes) were evaluated as ‘target genes’ (TG) to identify 21 ‘candidate genes’ (CG) and their relationship with neurological manifestations of COVID-19. TN was developed using neurological symptoms of COVID-19 found in literature. Under query genes (TG of TN), co-expressed genes were identified using pair-wise mutual information to genes available in RNA-Seq autopsy data of frontal cortex of COVID-19 victims. CGN was constructed with genes selected from TN and co-expressed in COVID-19. TG and their connecting genes of respective networks underwent functional analyses through findings of their enrichment terms and pair-wise ‘semantic similarity scores’ (SSS). A new integrated ‘weighted harmonic mean score’ was formulated assimilating values of SSS and STRING-based ‘combined score’ of the selected TG-pairs, which provided CG-pairs with properties of CGs as co-expressed and ‘indispensable nodes’ in CGN. Finally, six pairs sharing seven ‘prevalent CGs’ (ADAM10, ADAM17, AKT1, CTNNB1, ESR1, PIK3CA, FGFR1) showed linkages with the phenotypes (a) directly under neurodegeneration, neurodevelopmental diseases, tumour/cancer and cellular signalling, and (b) indirectly through other CGs under behavioural/cognitive and motor dysfunctions. The pathophysiology of ‘prevalent CGs’ has been discussed to interpret neurological phenotypes of COVID-19.
Teleportation of hybrid entangled states with continuous-variable entanglement
Authors: He Mingjian , Malaney Robert 
Published: October 2022

AbstractHybrid entanglement between discrete-variable (DV) and continuous-variable (CV) quantum systems is an essential resource for heterogeneous quantum networks. Our previous work showed that in lossy channels the teleportation of DV qubits, via CV-entangled states, can be significantly improved by a new protocol defined by a modified Bell state measurement at the sender. This work explores whether a new, similarly modified, CV-based teleportation protocol can lead to improvement in the transfer of hybrid entangled states. To set the scene, we first determine the performance of such a modified protocol in teleporting CV-only qubits, showing that significant improvement over traditional CV-based teleportation is obtained. We then explore similar modifications in the teleportation of a specific hybrid entangled state showing that significant improvement over traditional CV-based teleportation is again found. For a given channel loss, we find teleporting the DV qubit of the hybrid entangled state can always achieve higher fidelity than teleporting the CV qubit. We then explore the use of various non-Gaussian operations in our modified teleportation protocol, finding that, at a cost of lower success probability, quantum scissors provides the most improvement in the loss tolerance. Our new results emphasize that in lossy conditions, the quantum measurements undertaken at the sender can have a surprising and dramatic impact on CV-based teleportation.
Optical tomography dynamics induced by qubit-resonator interaction under intrinsic decoherence
Authors: Mohamed A. -B. A. , Eleuch H. 
Published: October 2022

AbstractA superconducting circuit with a qubit and a resonator coupled via a two-photon interaction is considered. When the resonator is initially in a superposition of coherent states, optical tomography and quantum coherence dynamics are examined in the context of intrinsic decoherence. The results reveal that optical tomography is a good quantifier of the quantum coherence produced by the qubit-resonator interaction. The effects of qubit-resonator detuning and intrinsic decoherence on the dynamics of optical tomography distributions for coherent and even coherent states are investigated. The dynamics of optical tomography distributions are highly dependent on detuning and intrinsic decoherence. Our numerical simulations reveal that there is a relation between the optical tomography and the generated quantum coherence. When the qubit-resonator detuning and intrinsic decoherence are augmented, the amplitude and intensity, as well as the structure of the optical tomography, change substantially.
Anthropogenic microparticles in the emerald rockcod Trematomus bernacchii (Nototheniidae) from the Antarctic
Authors: Bottari Teresa , Nibali Valeria Conti , Branca Caterina , Grotti Marco , Savoca Serena , Romeo Teresa , Spanò Nunziacarla , Azzaro Maurizio , Greco Silvestro , D’Angelo Giovanna , Mancuso Monique 
Published: October 2022

AbstractAnthropogenic microparticles (AMs) were found for the first time in specimens of Trematomus bernacchii collected in 1998 in the Ross Sea (Antarctica) and stored in the Antarctic Environmental Specimen Bank. Most of the identified AMs were fibers of natural and synthetic origin. The natural AMs were cellulosic, the synthetic ones were polyester, polypropylene, polypropylene/polyester, and cellulose acetate. The presence of dyes in the natural AMs indicates their anthropogenic origin. Five industrial dyes were identified by Raman spectroscopy with Indigo occurring in most of them (55%). Our research not only adds further data to the ongoing knowledge of pollution levels in the Antarctic ecosystem, it provides an interesting snapshot of the past, highlighting that microplastics and anthropogenic fiber pollution had already entered the Antarctic marine food web at the end of the ‘90 s. These findings therefore establish the foundations for understand the changes in marine litter pollution over time.
Naïve pluripotent-like characteristics of non-tumorigenic Muse cells isolated from human amniotic membrane
Authors: Ogawa Eiji , Oguma Yo , Kushida Yoshihiro , Wakao Shohei , Okawa Kana , Dezawa Mari 
Published: October 2022

AbstractMultilineage-differentiating stress-enduring (Muse) cells are non-tumorigenic pluripotent-like stem cells that exhibit triploblastic differentiation and self-renewability at the single-cell level, and are collectable as pluripotent surface marker SSEA-3(+) from the bone marrow (BM), peripheral blood, and organ connective tissues. SSEA-3(+) cells from human amniotic membrane mesenchymal stem cells (hAMSCs) were compared with hBM-Muse cells. Similar to hBM-Muse cells, hAMSC-SSEA-3(+) cells expressed pluripotency genes (OCT3/4, NANOG, and SOX2), differentiated into triploblastic cells from a single cell, self-renewed, and exhibited non-tumorigenicity. Notably, however, they exhibited unique characteristics not seen in hBM-Muse cells, including higher expression of genes related to germline- and extraembryonic cell-lineages compared with those in hBM-Muse cells in single-cell RNA-sequencing; and enhanced expression of markers relevant to germline- (PRDM14, TFAP2C, and NANOS3) and extraembryonic cell- (CDX2, GCM1, and ID2) lineages when induced by cytokine subsets, suggesting a broader differentiation potential similar to naïve pluripotent stem cells. t-SNE dimensionality reduction and Gene ontology analysis visualized hAMSC-SSEA-3(+) cells comprised a large undifferentiated subpopulation between epithelial- and mesenchymal-cell states and a small mesenchymal subpopulation expressing genes relevant to the placental formation. The AM is easily accessible by noninvasive approaches. These unique cells are a potentially interesting target naïve pluripotent stem cell-like resource without tumorigenicity.
Ultrafast 2DIR comparison of rotational energy transfer, isolated binary collision breakdown, and near critical fluctuations in Xe and SF6 solutions
Authors: Rotondaro Matthew C. , Jain Arkash , Erramilli Shyamsunder , Ziegler Lawrence D. 
Published: October 2022

The density dependence of rotational and vibrational energy relaxation (RER and VER) of the N2O ν3 asymmetric stretch in dense gas and supercritical Xe and SF6 solutions for near critical isotherms is measured by ultrafast 2DIR and infrared pump–probe spectroscopy. 2DIR analysis provides precise measurements of RER at all gas and supercritical solvent densities. An isolated binary collision (IBC) model is sufficient to describe RER for solvent densities ≤ ∼4M where rotational equilibrium is re-established in ∼1.5–2.5 collisions. N2O RER is ∼30% more efficient in SF6 than in Xe due to additional relaxation pathways in SF6 and electronic factor differences. 2DIR analysis revealed that N2O RER exhibits a critical slowing effect in SF6 at near critical density (ρ* ∼ 0.8) where the IBC model breaks down. This is attributable to the coupling of critical long-range density fluctuations to the local N2O free rotor environment. No such RER critical slowing is observed in Xe because IBC break down occurs much further from the Xe critical point. Many body interactions effectively shield N2O from these near critical Xe density fluctuations. The N2O ν3 VER density dependence in SF6 is different than that seen for RER, indicating a different coupling to the near critical environment than RER. N2O ν3 VER is only about ∼7 times slower than RER in SF6. In contrast, almost no VER decay is observed in Xe over 200 ps. This VER solvent difference is due to a vibrationally resonant energy transfer pathway in SF6 that is not possible for Xe.
Comparative effects of water potential stress induced by salt, alkali and drought on photosynthetic electron transport and apparatus in Hordeum jubatum seedlings
Authors: Shi Congcong , Fu Yanrong , Guo Yuqian , Ma Yuwen , Li Shuxin , Lin Jixiang , Wang Jinghong 
Published: October 2022

Context Photosynthetic electron transport and apparatus are highly susceptible to abiotic stressors during photosynthesis. Hordeum jubatum L. is an ornamental grass with excellent salt tolerance, used for soil improvement and ecological restoration in Northeast China. However, the comparative effects of salt, alkali and drought conditions on the photosynthetic apparatus of H. jubatum under uniform water potential are little known. Aims We explored the photosynthetic response of H. jubatum to uniform levels of water potential stress induced by three different stressors: salt, alkali and drought. Methods Seedlings of H. jubatum were irrigated with three concentrations of NaCl, NaHCO3 and PEG-6000 to induce water potentials of −0.21, −0.47 and −0.82 MPa. Transient fluorescence of chlorophyll a in the seedlings was measured, and JIP-test parameters were obtained. Key results Lower values of J–I phase fluorescence intensity and appearance of a K-band under stress treatments indicated restricted electron transfer from the oxygen-evolving complex in the donor of photosystem II. In addition, the values of ΔI-band and parameters MO and N increased, whereas those of Sm, ϕEo and ψO decreased, indicating interruption of electron flow between electron acceptors pheophytin and NADP+. Serious adverse effects of alkali stress on the acceptors were observed; the low water potential induced by NaHCO3 damaged the thylakoid membrane on the chloroplast, resulting in increased degradation of D1 protein. Conclusions The results suggest that H. jubatum seedlings have greater tolerance to salt and drought stress, but are highly sensitive to alkali stress in the photosynthetic system. Implications This study provides physiological information for the successful cultivation of H. jubatum under adverse environment conditions.
Iconicity of symmetries in language and in literature
Authors: Nöth Winfried 
Published: October 2022

Abstract
The paper discusses mirror symmetry, translational symmetry, and antisymmetry as the main types of symmetry of relevance to the study of language and literature. Based on the distinction between self-referential and alloreferential iconicity, it examines to what extent patterns of symmetry are iconic signs. Lewis Carroll’s Alice in Wonderland, 16th century title pages of incunabula, George Herbert’s picture poem Easter Wings, palindrome words, and lines from Gertrude Stein’s poetry are studied with respect to the iconicity of their forms of symmetry. The paper distinguishes between symmetries in the surface structure and in the deep structure and describes symmetries in the deep structure of language and literature as mental diagrams.
Iconicity for an iconoclast
Authors: Moyle Julian 
Published: October 2022

Abstract
Susan Howe’s poetry regularly draws attention to its appearance on the page, but the often abstract or iconoclastic nature of her work means that we rarely encounter cases where visual form mimes meaning in an obvious way. In places, though, Howe uses the iconic potential of abstract arrangements of text to target forms of representation that have been associated with the violence of colonization and with social injustice. A self-reflexive anxiety emerges as it becomes difficult to distinguish between the form of what is targeted and the form of the text itself. My study offers a close analysis of two examples: the opening of Secret History of the Dividing Line (1978) and a lyric from Bed Hangings (2001) that is framed by an illustration (by the artist Susan Bee) which helps to reveal the iconicity at work. I go on to relate Howe’s thinking about the nature of the sign – and of the relationship between words and the objects they represent – to Peirce’s ideas.