bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homotopy Perturbation Method applied to the Berkhoff equation for wave propagation on uneven bottoms
Authors: Tanguy Jean-Michel 
Published: November 2022

Abstract
The paper is focussed on the application of the Homotopy Perturbation Method (HPM) to the wave propagation on uneven bottoms. The corresponding Berkhoff equation is solved on sloping bottoms with different types of boundary conditions: Dirichlet, Neuman or Robin. The matrix topology of the solution appears to be very effective in obtaining the water level inside the domain, as well as the reflection and the transmission coefficients. Different solutions are studied in the case of successive multiple slopes, with reference to Booij's experiments. The first part of the study is in the shallow water regime, where an analytical solution is known, suitable to validate the results obtained by the homotopy method. The second part is more general and necessitates to use an approximate solution of the wave dispersion relation: Hunt’s continuous function is chosen. The very good results obtained allow us to discretize any bottom bathymetry by a series of linear slopes. These experiments are completed with considerations on the great interest provided by the power of the semi-analytical solution HPM, which can be applied on smaller subdomains, avoiding restricted criteria in space, in order to give the solution on the infinite domain. This depends on the type of boundary conditions and the number of the homotopy orders.
Lithological Characteristics, Microfacies and Diagenetic History of The Lower Aptian (Lower Shuaiba Formation) in The United Arab Emirates
Authors: Alsharhan A.S. 
Published: November 2022

Abstract
The Aptian Lower Shuaiba Formation in the United Arab Emirates is characterized by four shallow-water carbonate lithological units: (a) thinly bedded argillaceous pellet- and foram-rich lime mudstones; (b) heavily bioturbated packstones and poorly washed grainstones rich in aragonitic bioclastic grains, pellets and intraclasts; (c) poorly bioturbated packstones and wackestones containing a moderate fossil content; and (d) wackestone containing molluscan debris and abundant stylolites. The thickness and reservoir quality of these units varies throughout fields in the UAE.
Sedimentary facies analysis shows that the lower part of the formation consists of nine different microfacies: intra biomicrudites; orbitolinid foram packstones; anomuran pellet grainstones; intramicrudites containing algal and rudist debris; poorly washed biopelsparites; sparse biomicrites with fossil fragments; mollusc biomicrudites with entire shells; sparse planktonic foram biomicrites; and calcareous shales. The depositional settings of these facies range from subtidal bank crests to adjacent open-shelf lagoons and isolated outer-shelf banks. In general, the bank crest and bank margin facies are more common at the base of the Shuaiba Formation with open-shelf lagoon facies most common at the top. Deposition of this mud-dominated unit of the basal Shuaiba occurred on and near isolated offshore banks in relatively shallow, quiet waters. Due to the shallow depth of the banks and the low energies during deposition, little bank-derived sediment was washed from the banks and into the adjacent shelfal facies sediments.
Diagenetic alteration in Lower Shuaiba sediments was minimal, with poor to moderate development of secondary porosity. The diagenetic characteristics most important to reservoir quality are secondary dissolution of aragonite; early lithification causing some of the section to resist compaction; pressure solution and stylolite formation; and late diagenetic cementation.
Effect of Antenatal Milk Expression Education on Lactation Outcomes in Birthing People with Pre-Pregnancy Body Mass Index ≥ 25: Protocol for a Randomized, Controlled Trial
Authors: Demirci Jill R. , Glasser Melissa , Bogen Debra L. , Sereika Susan M. , Ren Dianxu , Ray Kristin , Bodnar Lisa M. , O’Sullivan Therese , Himes Katherine 
Published: November 2022

Abstract
Background: Birthing people with pre-pregnancy body mass indices (BMIs) ≥ 25 kg/m2, particularly those without prior breastfeeding experience, are at increased risk for suboptimal lactation outcomes. Antenatal milk expression (AME) may be one way to counteract the negative effects of early infant formula supplementation common in this population.
Methods: This ongoing, randomized controlled trial in the United States evaluates the efficacy of a telelactation-delivered AME education intervention versus an attention control condition on lactation outcomes to one year postpartum among 280 nulliparous-to-primiparous, non-diabetic birthing people with pre-pregnancy BMI ≥ 25 kg/m2. The assigned study treatment is delivered via four weekly online video consultations between gestational weeks 37-40. Participants assigned to AME meet with study personnel and a lactation consultant to learn and practice AME. Instructions are provided for home practice of AME between study visits. Control group participants view videos on infant care/development at study visits. Participants complete emailed surveys at enrollment (340/7-366/7 gestational weeks) and 2 weeks, 6 weeks, 12 weeks, 6 months, and 12 months postpartum. Surveys assess lactation and infant feeding practices; breastfeeding self-efficacy, attitudes, and satisfaction; perception of insufficient milk; onset of lactogenesis-II; lactation support and problems; and reasons for breastfeeding cessation. Surveys also assess factors associated with lactation outcomes, including demographic characteristics, health problems, birth trauma, racial discrimination, and weight stigma. Health information and infant feeding data are abstracted from the pregnancy and birth center electronic health record. Milk samples are collected from the intervention group at each study visit and from both groups at each postpartum follow-up for future analyses. Qualitative interviews are conducted at six weeks postpartum to understand AME experiences. Primary outcomes of interest are breastfeeding exclusivity and breastfeeding self-efficacy scores at two weeks postpartum. Outcomes will be examined longitudinally with generalized linear mixed-effects modeling.
Discussion: This is the first powered trial evaluating the effectiveness of AME among U.S. birthing people and within a non-diabetic population with pre-pregnancy BMI ≥ 25 kg/m2. This study will also provide the first evidence of acceptability and effectiveness of telelactation-delivered AME.
Trial Registration: ClinicalTrials.gov: NCT04258709
Molecular characterization of horse nettle virus A, a new member of subgroup B in the genus Nepovirus
Authors: Zhou Jing , Hu Xiaojun , Vieira Paulo , III Benjamin Atha , McFarland Clint , Foster Joseph A. , Hurtado-Gonzales Oscar Pietro 
Published: November 2022

Abstract

A new RNA virus was discovered from a horse nettle plant using high throughput sequencing (HTS) and its full genome was characterized consisting of two molecules: RNA1 and RNA2 which are 7522 and 4710 nucleotides in length, respectively. Each molecule encodes a single open reading frame flanked by 5’ and 3’ untranslated regions (UTRs) followed by a poly(A) tail at the 3’ end. Genome organization and the phylogenetic analysis revealed its close relationship with subgroup B of nepoviruses, sharing minimal similarity with any known nepoviruses, and the recombination analysis also revealed its evolutionary history within the same subgroup. These results suggest the new virus, provisionally named as horse nettle virus A, represents a new species within the genus Nepovirus.
A Circulating MicroRNA Panel as a Novel Dynamic Monitor for Oral Squamous Cell Carcinoma
Authors: Piao Yudan , Jung Seung-Nam , Lim Mi Ae , Oh Chan , Jin Yan Li , Kim Hae Jong , Nguyen Quoc Khanh , Chang Jae Won , Won Ho-Ryun , Koo Bon Seok 
Published: November 2022

Abstract
Oral squamous cell carcinoma (OSCC) has high recurrence and mortality rates despite advances in diagnosis and treatment. Therefore, it is necessary to identify new biomarkers for early detection, efficient monitoring, and prognosis prediction. Since microRNA (miRNA) is stable and detectable in serum, it has been reported to inform the diagnosis and monitor disease progression through liquid biopsy. In this study, a circulating specific miRNA panel in OSCC patients was developed, and its usefulness as a dynamic monitor was validated. Small RNAs were extracted from the serum of OSCC patients (n = 4) and normal controls (n = 6) and profiled using next-generation sequencing. NGS identified 42 differentially expressed miRNAs (DEmiRNAs) in serum between patients with OSCC and healthy controls, with 3-fold differences (p < 0.05). Combining the 42 DEmiRNAs and The Cancer Genome Atlas (TCGA) databases OSCC cohort, 9 overlapping DEmiRNAs were screened out. Finally, 4 significantly up-regulated miRNAs (miR-92a-3p, miR-92b-3p, miR-320c and miR-629-5p) were identified from OSCC patients via validation in the Chungnam National University Hospital cohort. Application of the specific miRNA panel for distinguishing OSCC patients from healthy controls produced specificity and sensitivity of 97.8% and 74%, respectively. In addition, the serum levels of these 4 miRNAs significantly decreased after complete surgical resection and increased after recurrence. We suggest that circulating 4-miRNA panel might be promising non-invasive predictors for diagnosing and monitoring the progression of patients with OSCC.
Facile synthesis of N-doped carbon dots (N-CDs) for effective corrosion inhibition of mild steel in 1 M HCl solution
Authors: Matter E. A. , El-Naggar G. A. , Nasr F. , Ahmed Gaber Hashem Gaber 
Published: November 2022

Abstract
N-CDs, as a novel and eco-friendly inhibitor, were synthesized easily by hydrothermal carbonization technique aiming to inhibit mild steel corrosion in 1 mol. L− 1 HCl. XRD, TEM, SEM, FTIR, UV-vis spectrophotometer and photoluminescence (PL) were utilized to characterize N-CDs. Potentiodynamic polarization and electrochemical impedance spectroscopy techniques along with the complementary surface studies were combined to investigate the corrosion inhibition capability of N-CDs for MS. N-CDs were found nanometer-sized (≈ 4 nm) with quasi-spherical morphology and high crystallinity. Inhibition efficiency, directly proportional to concentration but inversely with temperature, was measured as high as 96.73% (PDP) and 95.21% (EIS) at 200 mg. L− 1. Inhibition mechanism refered mainly to adsorption process that good obeyed Langmuir adsorption isotherm. The surface studies, quantitatively verified by EDX, showed a smoother surface of MS in presence of the N-CDs. Furthermore, the UV- visible spectroscopy effectively revealed the complexations between iron and metal surfaces.
Inhibition of Polo-like kinase 1 (PLK1) triggers cell apoptosis via ROS-caused mitochondrial dysfunction in colorectal carcinoma
Authors: Feng Ya , Li Tianjiao , Lin Zhoujun , Li Yin , Han Xiao , Pei Xiaolin , Fu Zhenkun , Wu Qiao , Shao Di , Li Chenggang 
Published: November 2022

Abstract
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers. Polo-like kinase 1 (PLK1), a member of the serine/threonine kinase PLK family, is the most investigated and essential in the regulation of cell cycle progression, including chromosome segregation, centrosome maturation and cytokinesis. However, the nonmitotic role of PLK1 in CRC is poorly understood. In this study, we explored the tumorigenic effects of PLK1 and its potential as a therapeutic target in CRC. First, immunohistochemistry analysis revealed the significant accumulation of PLK1 in patient-derived CRC tissues compared with adjacent healthy tissues. Furthermore, PLK1 inhibition genetically or pharmacologically significantly reduced cell viability, migration and colony formation, and triggered apoptosis of CRC cells. Additionally, we found that PLK1 inhibition elevated cellular reactive oxygen species (ROS) accumulation and decreased the Bcl2/Bax ratio, which led to mitochondrial dysfunction and the release of Cytochrome c, a key process in initiating cell apoptosis. In summary, these data provide new insights into the pathogenesis of CRC and support the potential value of PLK1 as an appealing target for CRC treatment. Overall, the underlying mechanism of inhibiting PLK1-induced apoptosis indicates that the PLK1 inhibitor BI6727 may be a novel potential therapeutic strategy in the treatment of CRC.
Incidence and long-term outcome of laser pointer maculopathy in children
Authors: Farassat Navid , Boehringer Daniel , Luebke Jan , Ness Thomas , Agostini Hansjuergen , Reinhard Thomas , Lagrèze Wolf Alexander , Reich Michael 
Published: November 2022

Abstract
Purpose: Single center study to evaluate the incidence and long-term outcome of laser pointer maculopathy (LPM).
Methods: Medical records of 909,150 patients visiting our institution between 2007 and 2020 were screened in our electronic patient record system using the keywords "laserpointer," "laser pointer," and "solar".
Results: Eight patientes (6/2 male/female, 11 eyes) with a history of LPM were identified by fundoscopy and optical coherence tomography (OCT), all of whom were children (6/2 male/female). Mean age at injury was 12.1 years (range 6-16). Five children (62.5%) were injured between 2019 and 2020, three (37.5%) between 2007 and 2018. Median best corrected visual acuity (BCVA) of affected eyes at first presentation was 20/25 (range 20/50-20/16). Follow-up examination was performed in seven children (10 eyes) with a median follow-up period of 18 months (range 0.5-96). BCVA improved in 4 children (5 eyes; BCVA at follow-up 20/22.5, range 20/40-20/16). Three of these four children were treated with oral steroids. OCT revealed acute signs such as intraretinal fluid to resolve quickly while outer retinal disruption persisted until the last follow-up in eight of eleven eyes. These lesions resembled lesions of patients with solar retinopathy of which seven cases (11 eyes) were identified between 2007 and 2020.
Conclusion: Readily available consumer laser pointers can damage the retina and the underlying retinal pigment epithelium, possibly leading to long-lasting visual impairments. The number of laser pointer injuries has increased over the last years. Therefore, access to laser pointers for children should be strictly controlled.
Analysis of Higher Order Boundary-Value Problems
Authors: Habib Siddra , Azam Muhammad Khurshid , Asjad Muhammad Imran , Akgül Ali 
Published: November 2022

Abstract
The He-Homotopy Perturbation Method and Laplace Transform, or HPLM, is a dependable combination that we take into consideration in this study in order to obtain the series solution of both linear and nonlinear higher order two-point boundary value problems. It is indicated that the corresponding technique generates better results in terms of accuracy, easy computation and is therefore recommended to be used for various physical models in engineering and science. Numerical results of five numerical examples are compared with the exact solutions as well as known analytical and numerical schemes to reveal the efficiency and excellence of the HPLM.
2010 Mathematics Subject Classification. Primary 26A33, 35A20; Secondary 33B15.
Central European soil solution data record atmospheric metal deposition and legacy pollution
Authors: Petrash Daniel A. , Krám Pavel , Pérez-Rivera Katherine X. , Bůzek František , Čuřík Jan , Veselovský Frantisek , Novák Martin 
Published: November 2022

Abstract
Soil solution chemistry depends largely on mineralogy and organic matter properties of soil horizons with which they interact. Differing lithologies within a given catchment area can influence variability in soil cation exchange capacities and affect solute transport. Zero-tension and tension lysimeters were used to evaluate fast transport of solutes in the topsoil vs. slow diffusional matrix flow at the subsoil of three contrasting lithology catchments in a mid-elevation mountain forest. Our aim was to test the feasibility of lysimeters hydrochemical data as a gauge for legacy subsoil pollution. Due to contrasting lithologies, atmospheric legacy pollution prevailing at the soil-regolith interface is differently yet consistently reflected by beryllium, lead, and chromium soil solution concentrations of the three catchments. Geochemical (dis)equilibrium between the soil and soil matrix water governed the hydrochemistry of the soil solutions at the time of collection, potentially contributing to decreased dissolved concentrations with increased depths at sites with higher soil pH. A complementary isotopic data constrained potential seasonal responses and pointed to sufficiently long water-regolith interactions as to permit important seasonal contributions of groundwater enriched in chemical species to the topsoil levels. Our study also reflects subsoil equilibration with atmospheric solutes deposited at the topsoil, and thus provides guidance for evaluating legacy pollution in soil profiles derived from contrasting lithology.
Phase Transition Thermodynamic Properties of 2-Methylquinoline, 2- Chloroquinoline and 2-Phenylquinoline
Authors: Abdullah Rawand S. , Solomonov Boris N. 
Published: November 2022

Abstract
Quinoline derivatives are extremely used in medicine and industry. Therefore, the thermodynamic properties of them are essential to know their quality and stability in use. In this work, the thermodynamic characters of 2-methylquinoline (quinaldine), 2-chloroquinoline, and 2-phenylquinoline were investigated. Moreover, the evaporation enthalpy of the compounds were determined the solution calorimetry-additivity scheme approach at 298.15 K. The solution calorimetry was used to measure solution enthalpies of the compounds in benzene solvent at 298.15 K. While, the solvation enthalpy of the compounds were calculated by additivity scheme approach. In addition, the transpiration method was applied to determine the vapor pressure at various temperatures for 2-Chloroquinoline for the first time. As a result, the thermochemical properties; enthalpy, entropy, and Gibbs energy for 2-methylquinoline, 2-chloroquinoline and 2-phenylquinoline were determined from crystalline/liquid to gas phase. Moreover, the thermochemical characteristics values exhibited smaller uncertainties than those in literature data. Consequently, the phase transition thermodynamically studied on 2-position of the quinoline compound when substituted methyl, chloro and phenyl groups.
Novel determinants of cell size homeostasis in the opportunistic yeast Candida albicans
Authors: Chaillot Julien , Cook Michael , Sellam Adnane 
Published: November 2022

Abstract
The basis for commitment to cell division in late G1 phase, called Start in yeast, is a critical but still poorly understood aspect of eukaryotic cell proliferation. Most dividing cells accumulate mass and grow to a critical cell size before traversing the cell cycle. This size threshold couples cell growth to division and thereby establishes long-term size homeostasis. At present, mechanisms involved in cell size homeostasis in fungal pathogens are not well described. Our previous survey of the size phenome in Candida albicans focused on 279 unique mutants enriched mainly in kinases and transcription factors (Sellam et al. 2019). To uncover novel size regulators in C. albicans and highlight potential innovation within cell size control in pathogenic fungi, we expanded our genetic survey of cell size to include 1301 strains from the GRACE (Gene Replacement and Conditional Expression) collection. The current investigation uncovered both known and novel biological processes required for cell size homeostasis in C. albicans. We also confirmed the plasticity of the size control network as few C. albicans size genes overlapped with those of the budding yeast Saccharomyces cerevisiae. Many new size genes of C. albicans were associated with biological processes that were not previously linked to cell size control and offer an opportunity for future investigation. Additional work is needed to understand if mitochondrial activity is a critical element of the metric that dictates cell size in C. albicans and whether modulation of the onset of actomyosin ring constriction is an additional size checkpoint.
Internalizing Symptoms and their Impact on Patient Reported Health-Related Quality of Life and Fatigue among Patients with Craniopharyngioma during Proton Radiation Therapy
Authors: Mandrell Belinda , Guo Yuan , Li Yimei , Hancock Donna , Caples Mary , Ashford Jason , Merchant Thomas , Conklin Heather , Crabtree Valerie 
Published: November 2022

Abstract
Purpose
The aim of this study was to describe fatigue, health related quality of life (HRQOL) and brain tumor associated symptoms after surgical resection and during proton radiotherapy, using latent class analysis (LCA), and to determine if there is class membership change among pediatric patients with craniopharyngioma.
Methods
For all patients (n = 92), demographic and disease-related/clinical variables were attained, and patient reported outcomes were collected prior to proton therapy, week three, and at the completion of proton therapy. Mean score of fatigue, HRQOL, and brain tumor symptoms were compared over time and profiles identified. Factors that influenced profile status and transition probability were examined.
Results
Fatigue, HRQOL, and brain tumor symptoms improved over time during proton therapy; however, a subset remained in the lower profile 1 associated with increased internalizing behaviors, compared to profile 2.
Conclusion
Future study should explore the bidirectional relationship of sleep, worry and anxiety in the context of ongoing radiotherapy.
Characteristics and prognosis of mixed autoimmune hemolytic anemia: a retrospective study of 49 cases
Authors: Liu Yilin , Ge Meili , Li Xingxin , Huang Jinbo , Ren Xiang , Guo Wenjing , Shao Yingqi , Huo Jiali , Wang Min , Nie Neng , Zhang Jing , Jin Peng , Zheng Yizhou 
Published: November 2022

Abstract
Mixed autoimmune hemolytic anemia (mAIHA) is a rare type of autoimmune hemolytic anemia (AIHA) with poorly known natural characteristics. We retrospectively analyzed the characteristics of patients with mAIHA from January 2010 to December 2021 in our center. 49 cases diagnosed with mAIHA were enrolled to be retrospectively analyzed. mAIHA accounted for 13.8% (49 cases) of all 356 AIHA patients. The initial hemoglobin levels of 34.7% patients were lower than 60 g/L. Nearly half (44.9%) mAIHAs were secondary and had lower C3 levels than that in primary group (P = 0.03). 71.1% mAIHA patients received second-line or even third-line therapy, and the overall response rate was 93.3%. 13 primary patients received glucocorticoids only, of which 46.2% got complete response and 53.8% partial response. 8 primary patients received low-dose rituximab with a respond rate of 87.5% (median time 4 weeks). In regards of complications, 35.6% patients developed infections and 8.9% thrombotic events. The relapse rate was 60%, and lower initial Hb levels (P = 0.044) and primary etiology (P < 0.001) were risk factors for relapse. The 5-year overall survival rate was 93.6%. Lung infection (χ2 = 6.109, P = 0.013) and age ≥ 60 years old (χ2 = 8.501, P = 0.004) had been responsible for death. In conclusion, mAIHA should be treated differently and especially concerned the etiology behind it. Attention should be put on the risk factors of recurrence and effective treatments still need to be further explored.