bluuebunny/crossref_metadata_2025_split huggingface dataset:
The correlation analysis between childhood behavioral disturbance and maternal alexithymia: an observational study
Authors: Lin Yu-Chen , Lee Wei-Yang 
Published: May 2022

Abstract
Background
From the perspective of children's psychological development and psychoanalysis, the primary caregiver's response to children's behavior has a considerable impact on children's emotional and behavioral development. If caregivers lack the ability to empathize, difficulties in detecting and responding to children's emotions, which may lead to children's emotional and behavioral disorders. The purpose of this study is to preliminarily explore the correlation between children's behavioral and emotional disorders and the mother's inability to express emotions.
Method
We collected a total of 78 cases from outpatient clinics, aged between 3–13 years old. The Taiwan version of the " Toronto Alexithymia Scale" and "Children's Behavior Checklist" questionnaires were used as research tools, which were filled out by the mothers themselves. We use Spearman correlation tool for follow-up analysis.
Results
The factor 1, 2 and 3 of TAS are positively correlated with somatic complaint subscale of CBCL. (F2: p < 0.01; F1 and F3:P < 0.05); The factor 1 of TAS is positively correlated with internal subscale of CBCL(p < 0.05) and withdrawn subscale of CBCL(p < 0.05). We found significant associations TAS-Total and the SC subscale of CBCL (p < 0.05), and factor 1 of TAS and WD of CBCL on boy alone (p < 0.05). However, negative related association was noted between TAS-F3 and the SP subscale of CBCL (p < 0.05).
Conclusion
We infer that when mothers are less able to distinguish internal emotional feelings, children's emotions and behaviors tend to be internalized, and they are more likely to show withdrawal, complaints of physical discomfort, and depression and anxiety. In addition, boys tend to show withdrawal traits in the internalization dimension; girls tend to show depression and anxiety in that respectively. This study preliminarily shows that there is a partial correlation between mother’s alexithymia and children's emotional and behavioral disorders, and it is worth further exploring the impact of caregivers' emotional traits on children's growth in the future.
F-18 FDG PET/CT vs. RAI-WBS and neck USG in early diagnosis of recurrent differentiated thyroid cancer
Authors: Bakshi Jaimanti , Panda Naresh Kumar , Goyal Atul Kumar , Saini Jyoti , Baral Sovit Jung , Mittal Bhagwant Rai , Lal Anupam 
Published: May 2022

Abstract
Background: Differentiated thyroid cancer (DTC) contributes up to 90% of total thyroid malignancies, and due to high recurrence chances, post-operative surveillance is performed by regular clinical follow-ups with routine neck ultrasonography (USG) and radioactive iodine whole-body scan (RAI-WBS). Objectives: Positron emission tomography and computed tomography (F-18 FDG PET/CT) has emerged as promising tools for the early detection of many malignancies and therefore in the present study aims to analyze the effectiveness of F-18 FDG PET/CT 1 Springer Nature 2021 L A T E X template Recurrent differentiated thyroid cancer vs. RAI-WBS and neck USG in early diagnosis of recurrence in differentiated thyroid cancer after thyroidectomy. Methods: For this, total 30 patients diagnosed with the DTC were recruited in the study and were followed for the assessment of recurrence of the disease. Either F-18 FDG PET/CT or RAI-WBS and neck USG was used as a recurrence assessment tool and data was compared for the sensitivity and specificity of the tool. Results: The recurrence rate was found to be 26.67% in the present study. F-18 FDG PET/CT exhibited a significant advantage over RAI-WBS and neck USG for early detection of recurrence of DTC. F-18 FDG PET/CT was found to exhibit good sensitivity and high specificity compare to the RAI-WBS and neck USG for early detection of recurrence of DTC. Conclusion: F-18 FDG PET/CT is recommended to use in those cases which have a high suspicion of DTC recurrence but is marked negative in other imaging techniques.
Intersecting substance use treatment and harm reduction services: Exploring the characteristics and service-needs of a community-based sample of people who use drugs
Authors: Krawczyk Noa , Allen Sean T. , Schneider Kristin E. , Solomon Keisha , Shah Hridika , Morris Miles , Harris Samantha J. , Sherman Susan G. , Saloner Brendan 
Published: May 2022

Abstract
Background: Substance use treatment and harm reduction services are essential components of comprehensive strategies for reducing the harms of drug use and overdose. However, these services have been historically siloed, and there is a need to better understand how programs that serve people who use drugs (PWUD) are integrating these services. In this study, we compared treatment and harm reduction services offered by a multistate sample of substance use service providers and assessed how well they align with characteristics and needs of clients they serve early in the COVID-19 pandemic. Methods: We recruited a convenience sample of programs that deliver harm reduction and/or treatment services in 10 states. Program directors participated in a survey assessing the services offered at their program. We also recruited clients of these programs to participate in a survey assessing a range of sociodemographic and health characteristics, substance use behaviors, and health service utilization. We then cross-compared client characteristics and behaviors relative to services being offered through these programs. Results: We collected and analyzed data from 511 clients attending 18 programs which either offered treatment with medications for opioid use disorder (MOUD) (N=6), syringe service programs (SSP) (N=8), or both MOUD and SSP (N=4). All programs delivered a range of treatment and harm reduction services, with MOUD+SSP programs delivering the greatest breadth of services. There were discrepancies between services provided and characteristics and behaviors reported by clients: 80% of clients of programs that offered MOUD without SSP actively used drugs and 50% injected drugs; 40% of clients of programs that offered SSP without MOUD sought drug treatment services. Approximately half of clients were unemployed and unstably housed, but few programs offered direct social services.Conclusions: In many ways, existing programs are not meeting the service needs of PWUD. Investing in innovative models that empower clients and integrate a range of accessible and flexible treatment, harm reduction and social services can pave the way for a more effective and equitable service system that considers the long-term health of PWUD.
Landscape drivers and spatial scale predict epiphyte biodiversity across human-modified landscapes
Authors: PARRA-SANCHEZ Edicson , EDWARDS David 
Published: May 2022

Abstract
ContextHuman-driven landscape processes such as habitat loss and fragmentation act on biodiversity but their effects are mediated by spatial scale. Quantification of the effects of the spatial scale of landscape processes on biodiversity moves beyond a purely ecological concern, towards a pragmatic tool for conservation aiming to designing biodiversity-rich landscapes.ObjectivesWe conducted a multiscale study to quantify the direction of effect (positive, negative, or neutral) and spatial scale (scale of effect, SoE) that three landscape processes—habitat loss (forest cover), fragmentation (number of patches), and edge effects (edge density)—exert independently on epiphyte biodiversity. MethodsWe focused on hyperdiverse vascular epiphytes and orchid communities, sampled across 23 human-modified landscapes in the mountainous region of the eastern Colombian Andes. We consider 12 spatial scales ranging from 100-2400 m radii and use metrics of Hill numbers to quantify biodiversity responses. ResultsHabitat loss and edge effects act at fine spatial scales (SoE= 200 m radius), predicting low species richness and abundance distributions across epiphytes and orchid communities. Fragmentation negatively impacts orchid communities at coarse scales (SoE= 2400 m radius). However, the biodiversity-landscape relationship might be undetected if assessed at the incorrect spatial scales (Forest cover 800-1500 m; Fragmentation ≥ 300 m; and edge density ≤800 radii).ConclusionsWe showed that habitat loss, fragmentation, and edge effects all play a negative role on biodiversity, and their detectability and impact is scale dependant. To design landscapes that are beneficial for mountainous plant biodiversity, it is important to improve forest cover as well as to reduce fragmentation and edge effects.
Rare sugar L-sorbose exerts antitumor activity by impairing glucose metabolism
Authors: Gao Xiao-Dong , Xu Hui-Lin , Zhou Xiaoman , Chen Shuai , Xu Si , Li Zijie , Nakanishi Hideki 
Published: May 2022

Abstract
Rare sugars are monosaccharides with low natural abundance. They are structural isomers of dietary sugars, but hardly be metabolized. Here, we report that rare sugar l-sorbose induces apoptosis in various cancer cells. As a C-3 epimer of d-fructose, l-sorbose is internalized via the transporter GLUT5 and phosphorylated by ketohexokinase (KHK) to produce l-sorbose-1-phosphate (S-1-P). Cellular S-1-P inactivates the glycolytic enzyme hexokinase resulting in attenuated glycolysis. Consequently, mitochondrial function is impaired and reactive oxygen species are produced. Moreover, l-sorbose downregulates the transcription of KHK-A, a splicing variant of KHK. Since KHK-A is a positive inducer of antioxidation genes, the antioxidant defense mechanism in cancer cells can be attenuated by l-sorbose-treatment. Thus, l-sorbose performs multiple anticancer activities to induce cell apoptosis. In mouse xenograft models, l-sorbose inhibits the proliferation of tumors either alone or in combination with other anticancer drugs. These results demonstrate l-sorbose as an attractive therapeutic reagent for cancer treatment.
The Clinical Characteristic and Management of patients with nocardiosis in a tertiary hospital in China
Authors: Liu Peilin , Wang Zhiqian , Jian Zijuan , Liu Xuan , Li Yanming , Yan Qun , Zhong Baiyun , Liang Xianghui , Liu Wenen 
Published: May 2022

Abstract
Background: Nocardiosis is an uncommon opportunistic bacterial infection caused by Nocardia spp., and its incidence has increased significantly in recent years. This study aimed to summarize the clinical characteristics and management of nocardiosis to provide a reference for clinical diagnosis and treatment.Methods : This retrospective study was conducted based on the medical records of nocardiosis patients between January 2015 and December 2021 in a tertiary hospital in China.Results: Overall, 44 patients with nocardiosis were included in this analysis including 26 males and 18 females with a mean age of 50.4 ± 13.2 years. Connective tissue disease (CTD) was the most common underlying disease (16/44). Twenty-six patients were given immunosuppressive therapy. The most frequent infection sites were the lungs (17/44) and skin and soft tissue (8/44). Common symptoms included cough (23/44), expectoration (18/44), fever (15/44), and subcutaneous abscesses (15/44). Average microbiology laboratory detection time was 4.8 days. Twenty-nine patients were managed only with antimicrobial treatment, and 14 patients received both antimicrobial and surgical therapies. Trimethoprim-sulfamethoxazole (TMP-SMX) was the most commonly used antibiotic (31/44). Thirty-five patients were cured or improved, 6 patients were discharged from the hospital due to poor prognosis, and 1 patient died.Conclusion : Clinicians should be alert to immunocompromised patients, especially those with CTD, and tend to pulmonary or cutaneous infections. Smear microscopic examination and prolonged culture time may aid Nocardia identification. Patients with nocardiosis can be treated with antimicrobials or surgical therapy. TMP-SMX remains the mainstay treatment, and its early and prompt use may improve nocardiosis outcome.
Damage Analysis and Prediction in Glass Fiber Reinforced Polyester Composite Using Acoustic Emission and Machine Learning
Authors: S.Gholizadeh  
Published: May 2022

Abstract
One of the most pervasive types of structural problems in aircraft industries is fatigue cracking that can potentially occur without anticipation with catastrophic failures and unexpected downtime. Acoustic emission is a passive structural health monitoring (SHM) technique, since it offers real time damage detection based on stress waves generated by cracking in the structure. Machine learning techniques have presented great success over the past few years with a large number of applications. This study assesses the progression of damage occurring on glass fiber reinforced polyester composite specimens using two approaches of machine learning, namely, Supervised and Unsupervised learning. A methodology for damage detection and characterization of composite is presented. The result shows that machine learning can predict the failure. All predictive models and their performance as well as AE parameters had a direct relationship with the applied stress values, suggesting that these correlation coefficients are reliable means of predicting fatigue life in a composite material.
A retrospective evaluation of short-term results from colonic stenting as a bridge to elective surgery versus emergency surgery for malignant intestinal obstruction
Authors: Chongjing Mu , Lei Chen 
Published: May 2022

Abstract
Purpose
The efficacy and safety of self-expanding metallic stent (SEMS) placement as a bridge to elective surgery versus emergency surgercy to treat malignant intestinal obstruction is debated. This study aimed to evaluate the outcomes of patients with malignant intestinal obstruction treated using different procedure.
Methods
Subjects admitted to the authors’ department with colonic obstruction (n = 87) were studied. They underwent colonic stenting as a bridge to elective surgery (SEMS group: n = 14) or emergency surgery (ES group:n = 22).Their demographic characteristics, stoma rate, laparoscopy rate and postoperative complications were analyzed, and the potential risk factors of postoperative complications and the optimal time interval from SEMS implantation to elective surgery were explored.
Results
The stoma rate was 15.4% in the SEMS group versus 60.0% in the ES group (P = 0.015), and the postoperative co mplication rate was 7.7% in the SEMS group versus 40.0% in the ES group (P = 0.042). The proportion of patients undergoing laparoscopy in SEMS group was significantly higher than that in ES group (69.2% vs. 15.0%; P = 0.003).The effect of ASA gradeification on postoperative complications was statistically significant (OR = 24.565; P = 0.008). The Receiving operating characteristic(ROC) curve could not determine the optimal time interval between SEMS implantation and elective surgery (AUC = 0.466).
Conclusions
SEMS implantation has the advantages of lower temporary stoma rate, less postoperative complications and higher laparoscopy rate compared with ES in the treatment of left malignant intestinal obstruction. ASA grade is a risk factor for postoperative complications. However, larger sample size prospective randomized controlled trials(RCT) are still needed to confirm long-term oncological outcomes.
Testing persistence of ammonia emissions with historical data from 1770 to 2019 in 37 OECD countries
Authors: Sakiru Solarin , Bermejo Lorenzo , Gil-Alana Luis A. 
Published: May 2022

Abstract
We examine the historical time series data of ammonia emissions from 1770 to 2019 in 37 OECD countries by looking at its statistical properties in order to determine if the series display time trends and persistence. These two properties are very common in environmental data, and our results indicate that reversion to the mean only occurs in the case of Finland, while the null hypothesis of a unit root cannot be rejected in the case of Norway or Iceland. In all the other cases, the estimated value of the differencing parameter is much higher than 1, and this is consistent for the two assumptions made regarding the error term. Thus, shocks are expected to be permanent in all cases except Finland.
Prognostic significance of CDC20 expression in malignancy patients: a meta-analysis
Authors: Xian Feng , Yang Xuegang , Xu Guohui 
Published: May 2022

Abstract
Background: A plenty of previous researches have reported the prognostic value of Cell Division Cycle Protein 20(CDC20) in malignancy tumors. Nevertheless, these researches were restricted by the small sample databases and the results were not strongly consistent among them.Methods: Databases involving EMBASE, PubMed, Cochrane Library and Web of Science were carefully searched, and literatures investigating the prognostic effect of aberrantly expressing CDC20 among human cancers were collected for further analysis. We used both hazards ratios and its corresponding 95% confidence intervals to evaluate the connection among the survival rate of malignancy patients and the expression of CDC20.Results: There were 10 eligible researches involving 2342 participants which were included in this study. The outcomes suggested that highly expressing CDC20 was significantly correlated with worse clinical prognosis of overall survival (OS) (HR 2.52, 95% CI 2.13-2.99) in the multivariate analysis, that (HR 2.05, 95% CI 1.50-2.82) in the univariate analysis and recurrence-free survival (HR 2.08, 95% CI 1.46-2.98). Moreover, we discovered that elevated CDC20 expression was significantly connected with decreased overall survival in non-small cell lung cancer (HR 2.40, 95% CI 1.91-3.02) while no significant relevance between highly expressing CDC20.Conclusions: this meta-analysis demonstrated that highly expressing CDC20 might be an unfavorable prognostic biomarker for various malignancy patients, which can make great contributions to the clinical diagnosis and treatment.
Soil erosion control from trash residues at varying land slopes under simulated rainfall conditions
Authors: Singh Sachin Kumar , Vishwakarma Dinesh Kumar , Kashyap P. S. , Kumar Akhilesh , Kumar Pankaj , Kumar Rohitashw 
Published: May 2022

Abstract
Trash mulches are very effective in preventing soil erosion; reduce sediment transport rate, runoff rate and increasing infiltration. The study was carried out with the objectives to observe the sediment outflow from sugar cane leaf (trash) mulch treatments at selected land slopes under simulated rainfall conditions by using rainfall simulator of size 10 m × 1.2 m × 0.5 m with the locally available soil material collected from Pantnagar. In the present study, trash mulches with different quantities were selected to observe the effect of mulching in soil loss reduction. The quantity of mulche were taken as, 6 t/ha, 8 t/ha and 10 t/ha, three rainfall intensities viz. 11cm/h, 13cm/h and 14.65cm/h at 0%, 2% and 4% land slopes were selected. The duration of rainfall was fixed (10 minutes) for every mulch treatment. The total runoff volume was found to be varying with different mulch rates for particular rainfall input and land slope. The runoff distribution pattern was observed to be increasing with the increase in land slope. The average sediment concentration (SC) and outflow was found to be increasing with the increasing land slope, but SC and outflow decreased with increasing mulch rate for particular land slope and rainfall intensity. The SOR (SOR) for no mulch treated land was higher as compared to trash mulch treated lands. Mathematical relationships were developed for relating SOR, SC, land slope and rainfall intensity for a particular mulch treatment. It was observed that values of SOR and average SC had a good correlation with rainfall intensity and land slope for each mulch treatment. The correlation coefficients of developed models were found to be more than 90%.
Reduced immunogenicity and endowed antimicrobial activity in β-lactoglobulin by preparing edible bioconjugate
Authors: Yoshida Tadashi , Ikeda Risa , Kawai Shinya , Horiuchi Kengo , Matsuo Yuho , Hattori Makoto 
Published: May 2022

Abstract
β-lactoglobulin (BLG) and ε-polylysine (PL) were bound by using microbial transglutaminase. Dextran (Dex) was further conjugated to the BLG-PL conjugate by the Maillard reaction. Confirmation of conjugation was carried out by SDS-PAGE. From the results of isoelectric focusing, it was revealed that the isoelectric point of the BLG-PL conjugate was shifted to the basic side as compared with native BLG. Immunogenicity of BLG in BALB/c mice was lowered by conjugation with PL and further lowered by conjugation with Dex. By conjugation with PL and PL-Dex, antibacterial activity against S. aureus was endowed to BLG. Because the conjugation method in this study is a safe method, it is valuable in that it can be applicable to food processing.
Transient suppression of ovarian function Induced by Dulaglutide: a case report and review of the literature
Authors: Guo Yangyang , Xie Mengchen , Liu Yuting , Huang Jinhui , Wang Qiong , Wang Xin 
Published: May 2022

Abstract
BackgroundGlucagon-like peptide-1 (GLP-1) agonist (GLP-1RA) is a new type of hypoglycemic agent with profound effects on the reproductive system. We report a case of ovarian function suppressed by the long-acting GLP-1RA dulaglutide.Case presentationA 41-year-old Chinese female presented with amenorrhea after treatment with GLP-1RA dulaglutide for type 2 diabetes. Her sex hormone measurement showed that the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were increased, while estradiol(E2) level was decreased. Her symptoms improved after the stoppage of dulaglutide. However, LH and FSH levels were still above the normal range two months after discontinuing the injection of dulaglutide.ConclusionThe long-acting GLP-1RA dulaglutide may transiently suppress ovarian function. Because of their different structures and half-times, the individual impact on the reproductive system of each type of GLP-1RA should be monitored in the future.
Quantitative evaluation of pulmonary hypertension using 4D flow MRI: a retrospective study
Authors: Koike Hirofumi , Sueyoshi Eijun , Nishimura Takamasa , Morikawa Minoru , Uetani Masataka 
Published: May 2022

Abstract

PurposePulmonary hypertension (PH) is a severe vascular disorder that may affect 50% of patients with heart failure. Currently, right-sided heart catheterization is required to definitively diagnose PH. However, this method is invasive and thus may not be appropriate for repeated, long-term monitoring of PH patients. This retrospective study’s aim was to evaluate whether 4D flow magnetic resonance imaging (MRI) can be used to quantitively measure flow parameters to identify patients with PH. MethodsThe study cohort included 97 patients recruited from a single institution and divided into three groups based on echocardiographic estimate of pulmonary artery systolic pressure (PASP): normal group with PASP<36mmHg, borderline PH group with PASP of 37–50mmHg, and PH group with PASP>50mmHg. 4D flow MRI was used to quantitively assess blood flow and velocity, regurgitation, wall shear stress (WSS) and kinetic energy in the pulmonary artery trunk, right main pulmonary artery, and left pulmonary artery. Two experienced radiologists independently analyzed the MR images, blinded to clinical details. ResultsWe found a significant difference in WSS in the pulmonary artery trunk, right main pulmonary artery and left main pulmonary artery among the three patient groups. We also found significant differences in the kinetic energy and average through velocity in the pulmonary artery trunk and right main pulmonary artery, and significant differences in the flow rate in the right main pulmonary artery. ConclusionsThese data suggest that 4D flow MRI can quantitate pulmonary artery flow parameters and distinguish between patients with and without PH.