bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis
Authors: Chen Guangbo , Deutsch Gail H. , Schulert Grant S. , Zheng Hong , Jang SoRi , Trapnell Bruce , Lee Pui Y. , Macaubas Claudia , Ho Katherine , Schneider Corinne , Saper Vivian E. , de Jesus Adriana Almeida , Krasnow Mark A. , Grom Alexei , Goldbach‐Mansky Raphaela , Khatri Purvesh , Mellins Elizabeth D. , Canna Scott W. 
Published: February 2022

ObjectiveRecent observations in systemic juvenile idiopathic arthritis (JIA) suggest an increasing incidence of high‐mortality interstitial lung disease often characterized by a variant of pulmonary alveolar proteinosis (PAP). Co‐occurrence of macrophage activation syndrome (MAS) and PAP in systemic JIA suggests a shared pathology, but patients with lung disease associated with systemic JIA (designated SJIA‐LD) also commonly experience features of drug reaction such as atypical rashes and eosinophilia. This study was undertaken to investigate immunopathology and identify biomarkers in systemic JIA, MAS, and SJIA‐LD.MethodsWe used SOMAscan to measure ~1,300 analytes in sera from healthy controls and patients with systemic JIA, MAS, SJIA‐LD, or other related diseases. We verified selected findings by enzyme‐linked immunosorbent assay and lung immunostaining. Because the proteome of a sample may reflect multiple states (systemic JIA, MAS, or SJIA‐LD), we used regression modeling to identify subsets of altered proteins associated with each state. We tested key findings in a validation cohort.ResultsProteome alterations in active systemic JIA and MAS overlapped substantially, including known systemic JIA biomarkers such as serum amyloid A and S100A9, and novel elevations in the levels of heat‐shock proteins and glycolytic enzymes. Interleukin‐18 levels were elevated in all systemic JIA groups, particularly MAS and SJIA‐LD. We also identified an MAS‐independent SJIA‐LD signature notable for elevated levels of intercellular adhesion molecule 5 (ICAM‐5), matrix metalloproteinase 7 (MMP‐7), and allergic/eosinophilic chemokines, which have been previously associated with lung damage. Immunohistochemistry localized ICAM‐5 and MMP‐7 in the lungs of patients with SJIA‐LD. The ability of ICAM‐5 to distinguish SJIA‐LD from systemic JIA/MAS was independently validated.ConclusionSerum proteins support a systemic JIA–to‐MAS continuum; help distinguish systemic JIA, systemic JIA/MAS, and SJIA‐LD; and suggest etiologic hypotheses. Select biomarkers, such as ICAM‐5, could aid in early detection and management of SJIA‐LD.
Thermoluminescence dose–response of synthesized and doped hydroxyapatite: effect of formed crystal phases
Authors: Taghipour Parisa , Zolfagharpour Farhad , Daneshvar Hamideh , Ziaie Farhood 
Published: February 2022

AbstractIn this research work, pure and doped hydroxyapatite samples were synthesized using hydrolysis and hydrothermal methods to produce powder material. The crystal structure was carried out by producing data using the X‐ray diffraction system and the Rietveld method using material analysis using diffraction software. Then the sample was irradiated with different radiation absorbed doses, and their thermoluminescence response was investigated from the dosimetry point of view. The results showed that the synthesis method, doping, and annealing temperature could significantly affect the crystal structure and thermoluminescence dosimetry response of hydroxyapatite samples, consequently. The results showed that the high‐temperature annealing process and dopant could lead to the formation of the β‐TCP crystal phase during or after the synthesis of hydroxyapatite, and the percentage of this formed phase increased when raising the temperature, and finally led to increase in the thermoluminescence response.
Will financial development and clean energy utilization rejuvenate the environment in BRICS economies?
Authors: Zoaka Joshua Dzankar , Ekwueme Daberechi Chikezie , Güngör Hasan , Alola Andrew Adewale 
Published: February 2022

AbstractGlobal warming and environmental degradation caused essentially by changes in climate have attracted enormous surveillance considering the menace of its reverberation on the health of humans during the past two decades. Utilization of energy and financial development (FD) are among the key drivers of climatic change. Thus, using second‐generation panel cointegration (the Westerlund, 2007 error‐correction model), pooled mean group autoregressive distributive lag model (PMG‐ARDL), and the panel dynamic ordinary least square (PDOLS) estimation techniques, the paper scrutinized the nexus between financial development, clean energy usage, economic growth, and environmental quality (proxied by CO2 emissions) of BRICS countries starting from 1980 to 2018. The findings from the study reveal that economic growth and labor force participation, in the long run, deteriorate the environmental quality by increasing the effusion of carbon. Contrarily, financial development, industrialization, trade openness, and renewable energy usage enhance the environmental quality of BRICS countries in the long run. In the short run, financial development was found to have a significant positive impact on the environmental quality of Brazil, China, and Russia, while it is negative for South Africa and India. The outcome of the PVECM Granger causality test reveals a two‐way Granger causality that runs from renewable energy to carbon emissions in the short run. The policy implication of this study is that the government of BRICS countries needs to concentrate on improving their clean energy sources and also work on their industries. The BRICS nations' governments should formulate financial and trade policies that promote a sustainable environment and economic development.
Impact ofCOVID‐19 pandemic on household financial decisions: A consumer vulnerability perspective
Authors: Yazdanparast Atefeh , Alhenawi Yasser 
Published: February 2022

AbstractThis study joins a rapidly growing body of research that investigates the multi‐faceted impacts of the Covid‐19 pandemic on consumers' behavior. Specifically, we examine how the pandemic‐induced state of vulnerability impacts consumers' saving, investing, and spending decisions. Using survey data from four different countries (i.e., USA, UK, South Africa, and Mexico), we examine the role of personality on consumer vulnerability, create an index of consumer vulnerability, and establish the role of vulnerability in impacting important financial decisions. We report evidence that perceptions of vulnerability and the pandemic‐induced changes in financial and consumption behaviors vary across residents of developed and developing countries. The results indicate that vulnerability is experienced and reflected through a multitude of fears and concerns and is influenced by personality traits (agreeableness, neuroticism, conscientiousness, need for material resources, and need for body resources) and can result in increased spending on products/services that are not normally perceived as necessities. Our findings carry important theoretical and managerial implications.
Laryngitis after inhalation of liposomal amikacin
Authors: Morita Atsuho , Namkoong Ho , Hosoya Makoto , Hasegawa Naoki 
Published: February 2022

AbstractA 56‐year‐old woman with pulmonary Mycobacterium avium complex disease was started on inhalation liposomal amikacin. One month later, she developed hoarseness and was diagnosed with laryngitis. The laryngitis healed immediately after treatment discontinuation, and no recurrence occurred even after resuming intermittent inhalation.
The Cycle Stability and Rate Performance of LiNi0.8Mn0.1Co0.1O2 Enhanced by Mg Doping and LiFePO4 Coating
Authors: Zhang Jianru , Lan Ziwei , Xi Ruheng , Li Yuanyuan , Zhang Caihong 
Published: February 2022

AbstractNickel‐rich layered oxide LiNi0.8Mn0.1Co0.1O2 became one of the preferred cathode materials for lithium‐ion batteries because of its advantages in capacity, cost and environmental protection. However, increased nickel content inevitably leads to more serious structural deterioration, such as irreversible phase transition, unexpected side effects as well as Li+/Ni2+ mixing, etc. This results in poor cycle stability and rate performance. Herein, we proposed a co‐modification strategy for Mg doping and LiFePO4 coating to enhance the aforementioned electrochemical performance of LiNi0.8Co0.1Mn0.1O2. The results indicated that Mg0.02‐NCM@20LFP exhibited lower surface film resistance and charge transfer resistance than pristine material after 200 cycles at 1C. A cycle retention rate of 90.8 % can still be maintained after 100 cycles at 0.2C. When returning to 0.1C after 5C high magnification, 98 % of the capacity can be recovered, showing that the material has good structural integrity.
Factors Governing the Catalytic Insertion of CO2 into Arenes – A DFT Case Study for Pd and Pt Phosphane Sulfonamido Complexes
Authors: Hölscher Markus , Kemper Gregor , Jenthra Sangeth , Bolm Carsten , Leitner Walter 
Published: February 2022

AbstractThe potential of Pd/Pt complexes for catalytic carboxylation of arenes with CO2 is investigated by means of computational chemistry. Recently we reported that the bis[(2‐methoxyphenyl)phosphino]‐benzenesulfonamido palladium complex 1 inserts CO2 reversibly in its Pd−C(aryl) bond generating carboxylato complex 2. In the present work we study how geometric and electronic factors of various ligands and substrates influence the overall activation barrier (energy span, ES) of a potential catalytic cycle for arene carboxylation comprising this elementary step. The tendency of the key intermediates to dimerize and thus deactivating the potential catalysts is examined as well as the role of the base, which inevitably is needed to stabilize the reaction product. We show that Pd and Pt complexes I(Pd)‐L16‐S1 and I(Pt)‐L16‐S1 do not dimerize, enable the computation of complete catalytic cycles, and show interestingly low ES values of 26.8 and 24.5 kcal/mol, respectively.
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide‐Based Hybrid Compounds against SARS‐CoV‐2 and Cancer
Authors: Herrmann Lars , Yaremenko Ivan A. , Çapcı Aysun , Struwe Julia , Tailor Dhanir , Dheeraj Arpit , Hodek Jan , Belyakova Yulia Yu. , Radulov Peter S. , Weber Jan , Malhotra Sanjay V. , Terent'ev Alexander O. , Ackermann Lutz , Tsogoeva Svetlana B. 
Published: February 2022

AbstractThe newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) cause life‐threatening diseases in millions of people worldwide, in particular, in patients with cancer, and there is an urgent need for antiviral agents against this infection. While in vitro activities of artemisinins against SARS‐CoV‐2 and cancer have recently been demonstrated, no study of artemisinin and/or synthetic peroxide‐based hybrid compounds active against both cancer and SARS‐CoV‐2 has been reported yet. However, the hybrid drug's properties (e. g., activity and/or selectivity) can be improved compared to its parent compounds and effective new agents can be obtained by modification/hybridization of existing drugs or bioactive natural products. In this study, a series of new artesunic acid and synthetic peroxide based new hybrids were synthesized and analyzed in vitro for the first time for their inhibitory activity against SARS‐CoV‐2 and leukemia cell lines. Several artesunic acid‐derived hybrids exerted a similar or stronger potency against K562 leukemia cells (81–83 % inhibition values) than the reference drug doxorubicin (78 % inhibition value) and they were also more efficient than their parent compounds artesunic acid (49.2 % inhibition value) and quinoline derivative (5.5 % inhibition value). Interestingly, the same artesunic acid‐quinoline hybrids also show inhibitory activity against SARS‐CoV‐2 in vitro (EC50 13–19 μm) and no cytotoxic effects on Vero E6 cells (CC50 up to 110 μM). These results provide a valuable basis for design of further artemisinin‐derived hybrids to treat both cancer and SARS‐CoV‐2 infections.
In‐Situ Lattice Tunnel Intercalation of Vanadium Pentoxide for Improving Long‐Term Performance of Rechargeable Magnesium Batteries
Authors: Yang Jun , Miao Xiaowei , Zhang Chenrui , Zheng Jihui , Sun Chencheng , Zhang Yu , Geng Hongbo 
Published: February 2022

AbstractLayered V2O5 is a promising and versatile cathode for rechargeable magnesium batteries (RMBs), but its narrow interlayer spacing makes rapid Mg2+ diffusion difficult, resulting in poor electrochemical performance. Herein, a facile and scalable technique is established for tailoring the (001) spacing of V2O5 by in‐situ polyaniline polymerization. The intercalated polyaniline molecules operate as pillars in the V2O5 interlayer, providing plentiful storage sites as well as improved cation diffusivities of Mg ion. As expected, by using V2O5/polyaniline as the cathode (anode: Mg metal), a high specific capacity of 361 mAh g−1 with charging/discharging current density of 20 mA g−1 can be achieved for RMBs. Besides, V2O5/polyaniline electrode shows favorable rate capability with 103 mAh g−1 at 500 mA g−1 (500 cycles) and ultra long‐term cycling performance after 5000 cycles. Ex situ X‐ray photoelectron spectroscopy is used to study the magnesium storage mechanism of the V2O5/polyaniline electrode.
Carbon Felt Decorated with Carbon Derived from Spent Asphalt as a Low‐cost and High‐performance Electrode for Vanadium Redox Flow Batteries
Authors: Xu Zhizhao , Xu He , Hu Zhengyu , Wu Wenze , Xu Jian , Zhong Fangfang , Ding Mei , Zhu Xiaobo , Fu Hongyuan , Jia Chuankun 
Published: February 2022

AbstractVanadium redox flow batteries (VRFBs) have attracted much attention in the field of energy storage systems owing to their safety, long‐cycle life, and feasible scalability. However, the market penetration of VRFBs is still hindered by the poor performance of current carbon‐based electrodes. Herein, spent asphalt is employed as an efficient and low‐cost precursor to generate carbon decorating carbon felt for VRFB applications. By thermal decomposition treatment, the spent asphalt is converted into highly active pyrolytic carbon and deposited on surfaces of carbon felt. The as‐prepared carbon felt with increased active sites and improved hydrophility displays superior performance towards redox reactions of VO2+/VO2+ in terms of better electrochemical reversibility and faster reaction kinetics. Therefore, the VRFB cell with the carbon felt decorated with carbon derived from spent asphalt as cathode shows 85% energy efficiency which is higher than the pristine carbon felt cathode by 9%. Meanwhile, the energy efficiency and voltage efficiency are both stable during the cell cycling. This strategy can raise the value of the spent asphalt and improve the performance of VRFBs with the decorated carbon felt electrode shedding light on their commercial applications for large‐scale energy storage.
Reconfigurable Origami Transparent Cellulose Triboelectric Paper for Multi‐modal Energy Harvesting
Authors: Xiong Jiaqing , Li Yi , Gao Dace , Chen Jian , Parida Kaushik , Lee Pooi See 
Published: February 2022

AbstractFacile integration of foldability, transparency, and waterproofness in multi‐modality triboelectric nanogenerator (TENG) applications is interesting. Here, we realized a reconfigurable origami transparent cellulose electronic paper (CEP) as TENG for energy harvesting from water, wind, and human motion. A unique silver nanowires‐bundle mesh (AgBM) was embedded into a micron‐thick ethyl cellulose paper by spraying and transfer process. Operating in single‐electrode mode, the CEP‐TENG can harvest energy from human motions by tapping, scavenge wind energy via mechanical interaction, as well as harvest energy from water, including acidic and alkaline water in virtue of protection by an extra hydrophobic cellulose oleoyl ester nanocoating. Origami capability enables the CEP‐TENG to be reconfigurable in three‐dimensional mode to maximize the energy harvesting efficiency. The CEP‐TENG energy window was demonstrated under the flowing water to achieve a self‐powered lighting display. CEP‐TENG realizes the all‐weather and multi‐modality energy harvesting, promising for wearable and attachable power sources, self‐powered applications such as outdoor displays, windows, decorative accessories, and life‐saving appliances.
Surface Modification of Porous Silica Particles with Carbohydrate Scaffolds as Receptor Components for Molecular Recognition
Authors: Uchida Tsukasa , Nakamura Ayano , Shimazaki Hannah , Kanie Yoshimi , Kanie Osamu 
Published: February 2022

AbstractBiosensors play a pivotal role in diagnosis through specific receptor‐ligand interactions. However, receptor biomolecules such as proteins have inevitable stability issues due to denaturation. Alternatively, utilization of the small molecules multivalently presented on porous silica particles as receptor components is considered to address the stability issues. A series of receptor components was synthesized using carbohydrates as a chiral scaffold to support multiple functional groups. The synthesized molecules were attached on the porous silica particles. Raman spectral analyses of single silica particles in the presence of nitrobenzene derivatives revealed a specific interaction with 4‐nitrophenol among others using a confocal Raman microscope. Chiral selective recognition was also accomplished for (1S,3S)‐ and (1R,3R)‐2‐amino‐1‐(4‐nitrophenyl)‐1,3‐propanediols. Protected carbohydrate derivatives are shown to be useful as receptor components on porous silica particles.
Oxetane Monomers Based On the Powerful Explosive LLM‐116: Improved Performance, Insensitivity, and Thermostability
Authors: Born Max , Karaghiosoff Konstantin , Klapötke Thomas M. , Voggenreiter Michael 
Published: February 2022

Abstract3‐Bromomethyl‐3‐hydroxymethyloxetane represents an inexpensive and versatile precursor for the synthesis of 3,3‐disubstituted oxetane derivatives. In the present work, its synthesis was improved and energetic oxetanes based on the explosive LLM‐116 (4‐amino‐3,5‐dinitro‐1H‐pyrazole) prepared. Reaching detonation velocities and pressures of up to 7335 ms−1 and 20.9 GPa in combination with a high thermostability and insensitivity, these surpass the prior art by far. Next to a symmetric LLM‐116 derivative, three asymmetric compounds were prepared using azido‐, nitrato‐ and tetrazolyl‐moieties. All compounds were intensively characterized by vibrational‐, mass‐ and multinuclear (1H, 13C, 14N) NMR spectroscopy, differential scanning calorimetry and elemental analysis. The molecular structures were elucidated by single crystal X‐ray diffraction. Hirshfeld analysis allowed to estimate their sensitivity next to a practical evaluation using BAM standard procedures. Their performance was calculated using the EXPLO5 V6.04 code and a small‐scale shock reactivity test and initiation test demonstrated their insensitivity and performance.
Characteristics of post‐traumatic embitterment disorder of inpatients in a general hospital in China
Authors: Gao Yuting , Wang Xiaoyan , Tan Liangliang , Yang Ting , Shi Linhua , Chen Huanxin , Jiang Wenhao , Yuan Yonggui 
Published: February 2022

AbstractObjectiveEmbitterment and post‐traumatic embitterment disorder (PTED) is critical, merging through different cultures. We explored the prevalence and related clinical characteristics of PTED of inpatients in a general hospital in China.MethodTwo hundred inpatients (aged 18–65 years) from different departments were recruited by convenient sampling and standardized diagnostic interviews of PTED. Demographic data, Post‐traumatic Embitterment Disorder Self‐Rating Scale (PTED‐21), the Patient Health Questionnaire depression scale (PHQ‐9), Generalized Anxiety Disorder‐7 (GAD‐7) and the Patient Health Questionnaire depression scale (PHQ‐15) were collected on all participants.ResultsThe prevalence of PTED was 21% (42/200) in inpatients in China; besides, the rate of increased syndromal embitterment is 28% (56/200), including 42 patients diagnosed with PTED. PTED was mainly associated with stressful events, such as illness, work and complicated interpersonal relationships. Rheumatology department and respiratory department have the highest and second highest prevalence of PTED among all departments. PTED‐21 scores were significantly correlated with PHQ‐9, GAD‐7 and PHQ‐15 (all P < 0.01).ConclusionsThe present study shows that embitterment is a critical negative emotion in inpatients with somatic illnesses with comorbid depression, anxiety and somatic symptoms. PTED and feelings of embitterment should be given proper attention in diagnosing somatic patients, and it is crucial to enhance PTED screening and intervention in the future. Future intervention studies on post‐traumatic embitterment disorder could be done in general and especially in psychosomatic and somatic medicine.
Matrix Effects on Photoluminescence and Oxygen Sensitivity of a Molecular Ruby
Authors: Wang Cui , Kitzmann Winald R. , Weigert Florian , Förster Christoph , Wang Xifan , Heinze Katja , Resch‐Genger Ute 
Published: February 2022

AbstractThe molecular ruby analogue [Cr(ddpd)2]3+ (ddpd=N,N’‐dimethyl‐N,N’‐dipyridine‐2‐ylpyridine‐2,6‐diamine) exhibits near infrared (NIR) emission with a high photoluminescence (PL) quantum yield ΦPL of 11 % and a lifetime of 898 μs in deaerated water at room temperature. While ligand‐based control of the photophysical properties has received much attention, influences of the counter anions and microenvironment are still underexplored. In this study, the luminescence properties of the molecular ruby were systematically examined for the counter anions Cl−, Br−, [BF4]−, [PF6]−, [BPh4]−, and [BArF24]− in acetonitrile (MeCN) solution, in crystals, and embedded into polystyrene nanoparticles (PSNP). Stern‐Volmer analyses of the oxygen quenching studies in the intensity and lifetime domain showed the highest oxygen sensitivity of the complexes with the counter anions of [BF4]− and [BArF24]−, which also revealed the longest luminescence lifetimes. Embedding [Cr(ddpd)2][PF6]3 in PSNPs and shielding with poly(vinyl alcohol) yields a strongly NIR‐emissive oxygen‐insensitive material with a record ΦPL of 15.2 % under ambient conditions.
Step Evolution and Growth Rate on {101} Faces of Potassium Dihydrogen Phosphate Crystals Grown at High Supersaturation
Authors: Liu Hui , Li Weidong , Wang Shenglai 
Published: February 2022

AbstractThe surface micromorphology of the {101} faces of potassium dihydrogen phosphate (KDP) crystals grown at different supersaturation conditions is systematically compared using atomic force microscopy. The height and width of the crystals during different growth steps are measured. The pyramidal face growth rate of KDP crystals is tested by a laser polarization interference system. The X‐ray rocking curve is used to measure the structural perfection of the {101} face of the KDP crystals. The results show that the growth rate of the {101} face increases with the supersaturation degree, and the rate is faster than that of the {100} face at a low supersaturation degree. Step bunching first increases and then decreases upon increasing the supersaturation, and the step height reaches a maximum value of about 6.0–6.9 nm at σ = 0.08 and 0.09. The crystal structural perfection is the worst under these conditions. It should be noted that 2D nuclei form on the surface terraces when the supersaturation is about 0.07. Dendrite‐like steps may be formed due to the development of these 2D nuclei. This work provides a reference for further researching the step evolution law of other crystalline materials.