bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher Perceived Stress as an Independent Predictor for Lower Use of Emotion-Focused Coping Strategies in Hypertensive Individuals
Authors: Torres Laura Aló , Paradela Regina Silva , Martino Luiza Menoni , da Costa Danielle Irigoyen , Irigoyen Maria Claudia 
Published: May 2022

IntroductionIndividuals with high scores of perceived stress (PS) are more likely to develop arterial hypertension (AH) than those with low levels of stress. In addition to this, AH and stress are both independent risk factors for executive function (EF) impairment and worse quality of life (QoL). Therefore, strategies to control and cope with emotional stress are of paramount importance. However, less is known about the association of PS with EF, QoL, and coping in individuals with hypertension. This study aimed to evaluate the association of PS with EF performance, coping strategies use, and QoL in a sample of hypertensive patients.MethodsWe assessed a group of 45 hypertensive individuals (mean age = 58.42 ± 8.9 years, 71.11% female). The EF evaluation was: Frontal Assessment Battery; Controlled Oral Word Association Test—FAS; Letter-Number Sequencing subtest from the Wechsler Adult Intelligence Scale—Third Edition (WAIS-III); Digit Span subtest from the Wechsler Memory Scale-Revised (WMS-R) and Wisconsin Card Sorting Test. The type and frequency of coping strategies used were measured by the Brief Coping with Experienced Problems Scale (Brief-COPE). The World Health Organization Quality of Life Questionnaire Bref (WHOQOL-bref) was applied to measure QoL. The associations of the PS with EF performance, coping strategies, and QoL were investigated using univariate and multiple linear regression models adjusted for age, sex, education, systolic pressure, and depression symptoms.ResultsIn the multivariate analyses, higher PS was an independent predictor for a lower frequency of emotion-focused strategy use (β = −0.23; p = 0.03). However, PS was not significantly related to EF and Qol in this sample. The lower the PS, the greater the use of emotion-focused coping.ConclusionHypertensive individuals with high PS use less frequently positive emotion-focused coping strategies.
Brain Derived Neurotrophic Factor and Cognitive Dysfunction in the Schizophrenia-Bipolar Spectrum: A Systematic Review and Meta-Analysis
Authors: Dombi Zsófia B. , Szendi István , Burnet Philip W. J. 
Published: May 2022

BackgroundCognitive impairment is a core feature of disorders on the schizophrenia-bipolar spectrum, i.e., schizophrenia, bipolar disorder, and schizoaffective disorder. Brain-derived neurotrophic factor (BDNF) has been proposed to be a biomarker of cognitive impairment in these disorders as it plays a critical role in neuroplasticity and proposed to mediate some of the psychotropic effects of medication. However, despite numerous studies investigating the association between circulating BDNF and these disorders, no solid conclusions have been drawn regarding its involvement in cognitive impairment.ObjectivesThe current systematic review and meta-analysis aims to examine blood BDNF levels and cognitive dysfunction in patients on the schizophrenia-bipolar spectrum as well as to evaluate whether circulating BDNF measurements can act as a biomarker for cognitive dysfunction.MethodsStudies were identified by searching Embase and Medline databases for English language articles published in peer-reviewed journals between 2000 January and 2021 June according to the PRISMA guidelines. A total of 815 articles were identified of which 32 met the inclusion criteria for the systematic review – reporting on comparisons between blood BDNF levels and cognitive functions of schizophrenia or bipolar disorder patients versus healthy controls (no studies involving schizoaffective patients were specifically obtained for the time being). Twenty-four of these studies (19 with schizophrenia and 5 with bipolar disorder patients) were eligible to be included in the meta-analysis.ResultsOur findings indicated that circulating BDNF levels were significantly reduced in patients experiencing an acute episode of schizophrenia or bipolar disorder compared to healthy controls. Cognitive function was also found to be significantly worse in patients, however, correlations between BDNF levels and cognitive impairment were not always detected. Interventions, especially pharmacotherapy seemed to improve certain aspects of cognition and increase circulating BDNF levels.ConclusionCirculating BDNF alone does not seem to be a valid biomarker of cognitive dysfunction in patients with disorders on the schizophrenia-bipolar spectrum, owing to several confounding factors. Changes of the circulating levels of BDNF should be evaluated in a wider context of other stress-, immune-, and inflammatory-related factors.
Coping Using Sex, Health-Related Behaviors, and Mental Health During COVID-19 Lockdown in the UK
Authors: Daly Natasha , Jones Andrew , Garofalo Carlo , Uzieblo Kasia , Robinson Eric , Gillespie Steven M. 
Published: May 2022

BackgroundPeoples' sexual behaviors have changed during the period of enforced COVID-19 social distancing, in some cases, to cope with negative feelings during lockdown. Research on coping using sex is relatively restricted to samples of men with a history of sexual offending, and it is unknown whether coping using sex is associated with health-related behaviors and mental health in the general population.AimWe examined if coping using sex before and during lockdown was associated with adverse outcomes (i.e., self-perceived reduction in health-related behaviors and mental health) in a community sample.HypothesesWe hypothesized that participants who reported greater use of sex to cope in the weeks preceding lockdown would show a greater decline in health-related behaviors and mental health during lockdown. Furthermore, that changes in coping using sex resulting from lockdown would account for further variance in the worsening of health-related behaviors and mental health.MethodsParticipants were UK residents, aged 18–60 years, and fluent in English. 789 participants completed an online survey, providing demographic information, self-reported social distancing, loneliness, and coping using sex over a 14-day period during lockdown, and retrospectively preceding lockdown.OutcomesParticipants reported perceived changes in health-related behaviors and mental health symptomatology during lockdown compared to before the pandemic. They also self-reported levels of stress, anxiety and depression during lockdown.ResultsGreater coping using sex prior to lockdown predicted positive change in health-related behaviors, for example, higher scores were associated with participants reporting having exercised and slept more. It was also associated with higher trait levels of anxiety, stress and depression during lockdown. Changes in coping using sex from before to during lockdown did not predict perceived changes in health related behaviors or mental health symptomatology.ConclusionsOverall, greater coping using sex prior to lockdown was associated with worse mental health symptomatology during lockdown (anxiety, depression and stress), however, it was also associated with perceived positive change in health-related behaviors compared with before lockdown. This suggests that coping using sex may be associated with negative emotional reactions during lockdown, but may also be linked with positive change in health-promoting behaviors.
Delayed Diagnosis and Treatment of Cancer Patients During the COVID-19 Pandemic in Henan, China: An Interrupted Time Series Analysis
Authors: Liu Changpeng , Piao Heng , Zhang Tao , Yang Dongjian , Li Xiaoyan , Tang Xiance 
Published: May 2022

ObjectiveTo investigate the possible impact of lockdown policies on the diagnosis and treatment of cancer patients in Henan, China.Design, Setting, and ParticipantsWe collected data from the Henan Cancer Hospital, affiliated with Zhengzhou University. The monthly numbers of inpatient admissions from January 2014 to December 2019 were used to forecast the number of inpatient admissions in 2020, which was then compared to the actual number of patients admitted during the pandemic to evaluate how the actual number diverges from this forecast. We conducted an interrupted time series analysis using the autoregressive integrated moving average (ARIMA) model.Main Outcomes and MeasuresFor specific diagnoses, treatment modalities, and age groups, we compared the changes in monthly admissions after the pandemic with the forecasted changes from the model.ResultsThe observed overall monthly number of inpatient admissions decreased by 20.2% [95% confidence interval (CI), 11.7–27.2%], 78.9% (95% CI, 77.3–80.4%), and 40.9% (95% CI, 35.6–45.5%) in January, February, and March 2020, respectively, as compared with those predicted using the ARIMA model. After the lockdown, visits for all treatment modalities decreased sharply. However, apparent compensation and recovery of the backlog appeared in later surgeries. As a result, the number of patients who underwent surgery in 2020 (30,478) was close to the number forecasted by the ARIMA model (30,185). In the same period, patients who received other treatments or underwent examinations were 106,074 and 36,968, respectively; the respective numbers that were forecasted by ARIMA were 127,775 and 60,025, respectively. These findings depict a decrease of 16.9 and 38.4% in patients who received other treatments or underwent examinations only, respectively. Regarding diagnosis, the reported incidence of various cancers decreased dramatically in February, with varying extent and speed of recovery.Conclusion and RelevanceThe COVID-19 pandemic has significantly delayed the diagnosis and treatment of cancer in Henan, China. Long-term research should be conducted to assess the future effects of lockdown policies.
Automatic Calibration of the Adaptive 3D Scanner-Based Robot Welding System
Authors: Arko Peter , Jezeršek Matija 
Published: May 2022

An advanced automatic calibration procedure and its versatile usage in the context of the adaptive robot welding technology are presented. The 3D scanner-based robot welding system calibration is composed of the measurement of the reference plate and numerical optimization of the hand-eye and intrinsic parameters by minimizing the deviation between the measured and reference plate. The measurements of the reference plate are acquired from various robot poses (typically 15). The shape features of the reference plate are then detected, and finally, the calculation of hand-eye and intrinsic parameters is performed using Powell’s optimization algorithm, where the merit function presents an average deviation between the measured and reference geometry. Validation experiments show appropriate system accuracy which is better than 0.06 mm perpendicular to the scanning direction. This calibration procedure’s important features are complete automation and fast execution times (approximately 90 s). This enables its implementation into a regular daily robot self-maintenance and monitoring plan. The universal use of such a robot welding system is demonstrated in multi-layer heavy-duty welding of thick pipes on cast machined hollow parts and in precise laser welding of thin sheet metal parts.
Construction of a Metabolism-Related Long Non-Coding RNAs-Based Risk Score Model of Hepatocellular Carcinoma for Prognosis and Personalized Treatment Prediction
Authors: Zhang Peichen , Chen Liping , Wu Shengjie , Ye Bailiang , Chen Chao , Shi Lingyan 
Published: May 2022

Background: Long non-coding RNAs (lncRNAs) play a key regulatory role in tumor metabolism. Although hepatocellular carcinoma (HCC) is a metabolic disease, there have been few systematic reports on the association between lncRNA expression and metabolism in HCC.Results: In this study, we screened 557 metabolism-related lncRNAs in HCC. A risk score model based on 13 metabolism-related lncRNA pairs was constructed to predict the outcome and drug response in HCC. The risk score model presented a better prediction of the outcomes than that with common clinicopathological characteristics, such as tumor stage, grade, and status and aneuploidy score in both training and testing cohorts. In addition, patients in the high-risk group exhibited higher responses to gemcitabine and epothilone, whereas those in the low-risk group were more sensitive to metformin and nilotinib.Conclusion: The metabolism-related lncRNAs-based risk score model and the other findings of this study may be helpful for HCC prognosis and personalized treatment prediction.
Comment on Weitzman et al. Resistance to Antimalarial Monotherapy Is Cyclic. J. Clin. Med. 2022, 11, 781
Authors: van der Pluijm Rob W. , Visser Benjamin J. , Dondorp Arjen M. 
Published: May 2022

Weitzman et al. used PubMed text mining to determine the trends of antimalarial resistance over the last 40 years [...]
Comparison of the Microbiome of Artisanal Homemade and Industrial Feta Cheese through Amplicon Sequencing and Shotgun Metagenomics
Authors: Papadimitriou Konstantinos , Anastasiou Rania , Georgalaki Marina , Bounenni Rimi , Paximadaki Argiro , Charmpi Christina , Alexandraki Voula , Kazou Maria , Tsakalidou Effie 
Published: May 2022

Feta is the most renowned protected designation of origin (PDO) white brined cheese produced in Greece. The fine organoleptic characteristics and the quality of Feta rely on, among other factors, its overall microbial ecosystem. In this study, we employed 16S rDNA and internal transcribed spacer (ITS) amplicon sequencing, as well as shotgun metagenomics, to investigate the microbiome of artisanal homemade and industrial Feta cheese samples from different regions of Greece, which has very rarely been investigated. 16S rDNA data suggested the prevalence of the Lactococcus genus in the homemade samples, while Streptococcus and Lactobacillus genera prevailed in the industrial control samples. Species identification deriving from shotgun metagenomics corroborated these findings, as Lactococcus lactis dominated two homemade samples while Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus were found to be dominating one industrial sample. ITS data revealed a complex diversity of the yeast population among the samples analyzed. Debaryomyces, Kluyveromyces, Cutaneotrichosporon, Pichia, Candida, and Rhodotorula were the major genera identified, which were distributed in a rather arbitrary manner among the different samples. Furthermore, a number of potential metagenome-assembled genomes (MAGs) could be detected among assembled shotgun bins. The overall analysis of the shotgun metagenomics supported the presence of different foodborne pathogens in homemade samples (e.g., Staphylococcus aureus, Listeria monocytogenes, Enterobacter cloacae, and Streptococcus suis), but with low to very low abundances. Concluding, the combination of both amplicon sequencing and shotgun metagenomics allowed us to obtain an in-depth profile of the artisanal homemade Feta cheese microbiome.
The Prebiotic Effect of Australian Seaweeds on Commensal Bacteria and Short Chain Fatty Acid Production in a Simulated Gut Model
Authors: Shannon Emer , Conlon Michael , Hayes Maria 
Published: May 2022

Diet is known to affect the composition and metabolite production of the human gut microbial community, which in turn is linked with the health and immune status of the host. Whole seaweeds (WH) and their extracts contain prebiotic components such as polysaccharides (PS) and polyphenols (PP). In this study, the Australian seaweeds, Phyllospora comosa, Ecklonia radiata, Ulva ohnoi, and their PS and PP extracts were assessed for potential prebiotic activities using an in vitro gut model that included fresh human faecal inoculum. 16S rRNA sequencing post gut simulation treatment revealed that the abundance of several taxa of commensal bacteria within the phylum Firmicutes linked with short chain fatty acid (SCFA) production, and gut and immune function, including the lactic acid producing order Lactobacillales and the chief butyrate-producing genera Faecalibacteria, Roseburia, Blautia, and Butyricicoccus were significantly enhanced by the inclusion of WH, PS and PP extracts. After 24 h fermentation, the abundance of total Firmicutes ranged from 57.35–81.55% in the WH, PS and PP samples, which was significantly greater (p ≤ 0.01) than the inulin (INU) polysaccharide control (32.50%) and the epigallocatechingallate (EGCG) polyphenol control (67.13%); with the exception of P. comosa PP (57.35%), which was significantly greater than INU only. However, all WH, PS and PP samples also increased the abundance of the phylum Proteobacteria; while the abundance of the phylum Actinobacteria was decreased by WH and PS samples. After 24 h incubation, the total and individual SCFAs present, including butyric, acetic and propionic acids produced by bacteria fermented with E. radiata and U. ohnoi, were significantly greater than the SCFAs identified in the INU and EGCG controls. Most notably, total SCFAs in the E. radiata PS and U. ohnoi WH samples were 227.53 and 208.68 µmol/mL, respectively, compared to only 71.05 µmol/mL in INU and 7.76 µmol/mL in the EGCG samples. This study demonstrates that whole seaweeds and their extracts have potential as functional food ingredients to support normal gut and immune function.
Clinical, Pathological, and Genetic Characteristics in Patients with Focal Segmental Glomerulosclerosis
Authors: Nagano China , Hara Shigeo , Yoshikawa Norishige , Takeda Asami , Gotoh Yoshimitsu , Hamada Riku , Matsuoka Kentaro , Yamamoto Masaki , Fujinaga Shuichiro , Sakuraya Koji , Kamei Koichi , Hamasaki Yuko , Oguchi Hideyo , Araki Yoshinori , Ogawa Yayoi , Okamoto Takayuki , Ito Shuichi , Tanaka Seiji , Kaito Hiroshi , Aoto Yuya , Ishiko Shinya , Rossanti Rini , Sakakibara Nana , Horinouchi Tomoko , Yamamura Tomohiko , Nagase Hiroaki , Iijima Kazumoto , Nozu Kandai 
Published: May 2022

Key Points

We investigated the association between focal segmental glomerulosclerosis histologic variants (Columbia classification) and monogenic variant detection rates.The perihilar variants had the strongest association with detection of monogenic variants.The tip variants had the weakest association with detection of monogenic variants.

Background
Approximately 30% of children with steroid-resistant nephrotic syndrome (SRNS) have causative monogenic variants. SRNS represents glomerular disease resulting from various etiologies, which lead to similar patterns of glomerular damage. Patients with SRNS mainly exhibit focal segmental glomerulosclerosis (FSGS). There is limited information regarding associations between histologic variants of FSGS (diagnosed using on the Columbia classification) and monogenic variant detection rates or clinical characteristics. Here, we report FSGS characteristics in a large population of affected patients.

Methods
This retrospective study included 119 patients with FSGS, diagnosed using the Columbia classification; all had been referred to our hospital for genetic testing from 2016 to 2021. We conducted comprehensive gene screening of all patients using a targeted next-generation sequencing panel that included 62 podocyte-related genes. Data regarding patients’ clinical characteristics and pathologic findings were obtained from referring clinicians. We analyzed the associations of histologic variants with clinical characteristics, kidney survival, and gene variant detection rates.

Results
The distribution of histologic variants according to the Columbia classification was 45% (n=53) FSGS not otherwise specified, 21% (n=25) cellular, 15% (n=18) perihilar, 13% (n=16) collapsing, and 6% (n=7) tip. The median age at end stage kidney disease onset was 37 years; there were no differences in onset age among variants. We detected monogenic disease-causing variants involving 12 of the screened podocyte-related genes in 34% (40 of 119) of patients. The most common genes were WT1 (23%), INF2 (20%), TRPC6 (20%), and ACTN4 (10%). The perihilar and tip variants had the strongest and weakest associations with detection of monogenic variants (83% and 0%, respectively; P<0.001).

Conclusions
We revealed the distributions of histologic variants of genetic FSGS and nongenetic FSGS in a large patient population. Detailed data concerning gene variants and pathologic findings are important for understanding the etiology of FSGS.
Patrimonio, pueblos originarios y prácticas del secreto
Authors: Crespo Carolina , Brosky Jacqueline 
Published: May 2022

No cabe duda acerca de la relevancia que está adquiriendo el patrimonio en las últimas décadas. Numerosos estudios caracterizan a este período como boom, inflación o abuso patrimonial y han proliferado la cantidad de cientistas sociales que debaten al respecto. En gran medida, aquello que legitimó y sigue haciéndolo a estas políticas es el mandato moral de la transmisión, la persistencia en el tiempo, el conjuro contra el olvido y la desaparición; aunado, en las últimas décadas, con el reconocimiento de la diversidad. Estos mandatos, positivamente valorados, opacan la politicidad y avasallamientos de estas políticas de patrimonialización, los afectos-efectos y tensiones que generan y el debate sobre los límites de lo patrimonializable. En tal sentido, sin dejar de reflexionar sobre aquello que el patrimonio hace con las expresiones culturales de la vida cotidiana, saberes y cosmovisiones indígenas, proponemos concentrarnos en repensar el camino inverso, esto es, que es lo que hacen esas manifestaciones y cosmovisiones indígenas con el patrimonio. Con este propósito, a partir de algunos ejemplos etnográficos derivados de nuestro trabajo de campo con el pueblo mbyá guaraní y mapuche, discutimos acerca del papel complejo y heterogéneo que juegan las prácticas de secrecía indígenas en los procesos de patrimonialización.
Cosmetic, Conversation, or Commitment: A Study of EDI Corporate Messages, Motives, and Metrics After George Floyd’s Murder
Authors:   Center for Creative Leadership, Dawkins Marcia , Balakrishnan Ramya 
Published: May 2022

"“We know that systemic racism is real. It has been persistent. And it can’t be wished away.” “Our identity, our very existence is rooted in empowering everyone on the planet.” “We commit $10 million to aid organizations dedicated to equality and social justice.” Each of these statements is a response to one event: the collective citizen witnessing of George Floyd’s murder in 2020. Each statement tells a different story, complete with heroes, villains, plot twists, and resolutions. As such, this study explored the stories told and commitments made by corporations in their responses to systemic racism after George Floyd’s murder. We sought to uncover relationships between statement content, leader motive, and proposed organizational culture change. Blending computational and communication research methods, we found and identified three thematic elements and seven equity, diversity, and inclusion (EDI) strategies. Findings suggest organizations used statements to explain what witnessing Floyd’s murder means, share leaders’ motivations for doing EDI work, and propose socially responsible actions. More specifically, the results of this study offer the following insights. •	Three themes emerged. Oppression is everywhere, all the time; Leaders can be heroes; Messages and metrics should match. •	Three motives were found to underly EDI strategies, ranging from surface level compliance to in-depth change. These are EDI as cosmetic tool, conversation starter, and commitment driver. •	Cosmetic motives are overrepresented, as 95.98% of statement content lacks key details accounting for long-term culture change. While corporate statements were spurred by a here-and-now situation, the issue of systemic racism is ongoing. Therefore, these insights suggest the need for continued evaluation of statements in the context of quantitative and qualitative indicators, paying particular attention to employee reviews, diversity metrics, and social responsibility. The current paper provides an overview of statement content as it relates to equity, diversity, and inclusion (EDI) and includes advice on what leaders can do as they embrace transparency and promote accountability.