bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D deficiency is frequent and selenium deficiency is rare in newly diagnosed breast cancer patients
Authors: Zemlin Cosima , Altmayer Laura , Stuhlert Caroline , Schleicher Julia Theresa , Wörmann Carolin , Lang Marina , Scherer Laura-Sophie , Thul Ida Clara , Spenner Lisanne Sophie , Simon Jana Alisa , Wind Alina , Kaiser Elisabeth , Stutz Regine , Goedicke-Fritz Sybelle , Wagenpfeil Gudrun , Zemlin Michael , Solomayer Erich-Franz , Müller Carolin 
Published: July 2022

Abstract
Purpose:In recent years, controversial discussions increased whether vitamin D and selenium have an influence on cancer. In the present study, we examined serum vitamin D and selenium levels in breast cancer patients and potential influencing factors. Methods:110 non-metastatic breast cancer patients were included in the prospective observational “BEGYN” study at Saarland University Medical Center between September 2019 and January 2021. Clinicopathological characteristics were documented. At the baseline visit prior to therapy initiation serum vitamin D and selenium levels were measured and patients received a questionnaire on sun exposure, nutrition, and supplement use.Results:Median vitamin D value was 24 µg/l, and median selenium level was 81 µg/l. Vitamin D levels were higher among the 17 patients that reported the use of vitamin D substitution (43 µg/l versus 22 µg/l; p<0.001). In the univariate analysis, vitamin D levels were higher in summer compared to spring (p=0.004), autumn (p=0.028) and winter (p<0.001). Patients with triple negative carcinomas had a higher vitamin D level (+8,9 µg/l compared to other sub entities, p=0.035). The consumption of cream, gouda, and butter was associated with slightly lower vitamin D levels (regression coefficient: -0.36; p=0.004). Vitamin D and selenium levels are comparable to the healthy German population.Conclusion:Almost 2/3 of all breast cancer patients suffer from vitamin D deficiency at diagnosis, whereas selenium levels were in normal range in 96.2 % of the patients. Vitamin D should be measured routinely, to prevent side effects of vitamin D deficiency.
Cloning, functional characterization and evaluating potential in metabolic engineering for lavender (+)-bornyl diphosphate synthase
Authors: Adal Ayelign M. , Najafianashrafi Elaheh , Sarker Lukman S. , Mahmoud Soheil S 
Published: July 2022

Abstract
The monoterpene (+)-borneol contributes scent and medicinal properties to some plants. It also is the immediate precursor to camphor, another important determinant of aroma and medicinal properties in many plants. (+)-borneol is generated through the dephosphorylation of bornyl diphosphate (BPP), which is itself derived from geranyl diphosphate (GPP) by the enzyme (+)-bornyl diphosphate synthase ((+)-BPPS). In this study we isolated and functionally characterized a novel (+)-BPPS cDNA from Lavandula x intermedia. The cDNA excluding its transit peptide was expressed in E. coli, and the corresponding recombinant protein was purified with Ni–NTA agarose affinity chromatography. The recombinant (+)-LiBPPS catalyzed conversion of GPP to BPP as the major product, and a few minor products. We also investigated the in planta role of (+)-LiBPPS in terpenoid metabolism through its overexpression in sense and antisense orientations in stably transformed Lavandula latifolia plants. The overexpression of (+)-LiBPPS in antisense resulted in reduced production of (+)-borneol and camphor without compromising plant growth and development. As anticipated, the overexpression of the gene led to enhanced production of borneol and camphor, although growth and development were severely impaired in most transgenic lines strongly and ectopically expressing the (+)-LiBPPS transgene in sense. Our results demonstrate that LiBPPS would be useful in studies aimed at the production of recombinant borneol and camphor in vitro, and in metabolic engineering efforts aimed at lowering borneol and camphor production in plants. However, overexpression in sense may require a targeted expression of the gene in glandular trichomes using a trichome-specific promoter.
Effect of poplar (Populus nigra) spring and autumn leaves extract on pepper (Capsicum annuum) infected with pepper mild mottle virus under greenhouse conditions
Authors: Gharib Hesham Abd El Salam , Mandour Aiman Mohamed 
Published: July 2022

Abstract
Capsicum annuum is one of the main vegetable crops for the local market and exportation in Egypt. In this concern, pepper mild mottle virus (PMMoV) infection caused a significant decrease in Capsicum sp. yield, leading to large economic losses. An isolate of PMMoV was got from naturally infected pepper plants, exhibiting different patterns of mottling, leaf distortion, yellowing, and stunting of leaves. The virus was identified. The molecular detection of PMMoV was done using RT-PCR with specific primers designed for coat protein genes. An RT-PCR product (~ 474) bp of the coat protein gene of (PMMoV) was cloned. The target of the investigation was the effect of spring and autumn ethanol extracts of Populus nigra leaves on C. annuum seedling growth and infected C. annuum with (PMMoV) under greenhouse conditions. The experimental data showed that treated spring leaf extract of P. nigra enhanced infected C. annuum seedling growth parameters and fruit quality compared to uninfected seedlings. P. nigra spring leaf extract containing some allo-chemicals had a negative effect on uninfected seedlings. P. nigra autumn leaf extract significantly improved the growth and fruit quality of infected C. annuum seedlings compared to the control.
Interpretation of Land Use/Land Cover Dynamics with the Application of Geospatial Techniques in Sarbari Khad Watershed of Himachal Pradesh, India
Authors: KUMAR SUNIL , Singh Vartika , Saroha Jitender 
Published: July 2022

Abstract
Land Use/Land Cover (LULC) changes represent anthropogenic transformation of natural landscape. These changes are an important tool in developing strategies for the management of natural resources as well as monitoring environmental changes. LULC mapping and monitoring is required to understand the causes and consequences of over exploitation of natural resources such as soil, forest and water. By assessing the uses and misuses of resources and identifying the reasons for misuses, the measures for sustainable development of resources in the fragile Himalayan watersheds can be identified and implemented. The main objective of the present study is to assess the land use/land cover changes in the Sabari Khad watershed of KulluValley. The Sabari Khad watershed is part of Beas River basin. The changes in LULC have been detected by using remote sensing and GIS (Geographical Information System) techniques for a period of twelve years (2000–2021). The satellite images of the National European Space Agency Sentinal-2 of November, 2021 and LandSat-7 image of November 2000 were processed with the help of ERDAS Imagine (2015) and Arc View (3.2a) software. This study reveals that substantial amount of deforestation and snow cover retreat has occurred during this period of two decades due to anthropogenic activities such as expansion of agriculture, especially horticulture and infrastructure.
Correction of mould cavity geometry for warpage compensation
Authors: Kastelic Tomaž , Starman Bojan , Cafuta Gašper , Halilovič Miroslav , Mole Nikolaj 
Published: July 2022

Abstract
Warpage is one of the most challenging defects occurring in plastic injection moulded parts. Various approaches to overcome this issue have been proposed in the literature, but they all provide only partial solutions to the problem. This paper proposes a new method for the compensation and minimisation of warpage. The method is based on Mould Cavity (MC) correction. In contrast to other similar methods, here the MC correction is accomplished through a direct comparison of the local deviations of the warped part's geometry to the desired geometry of the part. Modifying the MC shape accordingly yields parts with a lower shape discrepancy from the desired geometry compared to the nonadjusted shape. The key novelty of the paper is the development of software that iteratively adjusts the MC shape to minimise local deviations. In every iteration, the warped part is compared to the desired geometry and the MC geometry is adjusted accordingly. A curved thin-walled plate part case study demonstrates the method's capabilities. We show that the maximum warpage value of 0.005 mm (0.7% of the initial maximum warpage) was reached after three iterations of MC geometry correction and remained stable afterwards.
Folk Nomenclature and Traditional knowledge of breadfruit [Artocarpus altilis (Parkinson) Fosberg] Diversity in the Caribbean
Authors: Daley Oral O. , Roberts-Nkrumah Laura B. , Alleyne Angela T. , Gloster Michael C. 
Published: July 2022

Abstract
Since its introduction in the Caribbean islands in 1793, breadfruit has had a diverse history in the region, and there is a considerable repository of traditional, yet undocumented knowledge of the crop, among residents of the region. Consequently, it remains underutilized as a food source, despite recognition of its potential to contribute to food and nutrition security. Understanding the folk taxonomy and traditional knowledge associated with its diversity and utilization is a prerequisite to develop programs for its commercial production and utilization. This study was conducted among 170 respondents, who were selected across the Caribbean by using a combination of simple random and snowball sampling techniques to collect and document information on the ethnobotany and traditional knowledge associated with breadfruit biodiversity, including systems of naming, identification and classification of breadfruit cultivars or types. Breadfruit has a high socio-cultural value and is produced for both home use and sale by most respondents (68%). The genetic diversity of breadfruit managed by the respondents is also important as a total of 51 vernacular names were uncovered with nine of those names recorded for the first time in this study. Breadfruit types were identified by morphology and agronomic characteristics, with other important traits relating to use and cooking quality. Classification of breadfruit cultivars or types was based on eating - quality, most suitable methods of preparation and ease of cooking. The ethnobotanical and traditional knowledge obtained from this study may be useful in assessing the genetic diversity of breadfruit and guiding future community-based conservation and classification studies of this important crop resource in the Caribbean. This is crucial to support the commercialization of breadfruit to improve its contribution to food and nutrition security.
Land Use Land Cover Dynamics Using CA-Markov Chain Model and Geospatial Techniques: A Case of Belete Gera Regional Forest Priority Area, South Western Ethiopia.
Authors: Gemmechis Wendafiraw Abdisa 
Published: July 2022

Abstract
Arrogant practices of land use including expansion of agricultural land and infrastructural development are resulting in deforestation that goes to climate change. Cellular Automata (CA)-Markov chain combines the advantages of cellular and Markov chain analysis to simulate and predict future land use/cover trends depending on the Land Use Land Cover (LULC) changes in the past. First, spatial distribution of LULC and area changed were calculated using IDRISI software and GIS technology, and then the forest land cover conversion to other LULC was evaluated to obtain rate of deforestation during a period of 1980-2018. Second, using transition potential matrices of 1999-2018, CA-Markov chain was executed to simulate spatial distribution of land use/cover in 2018. Based on the simulated LULC map for 2018 and the actual LULC map of 2018 CA-Markov Model was validated with a kappa index of 1. Finally, future land use/cover transformed during the periods of 2018-2037 and 2037-2056 were predicted using CA-Markov Chain Model. The results revealed that decreasing of forest land and increasing of agricultural land in the study period. Forest land was decreased by 52,156.71 hectares from 1980 to 2018, while agricultural land increased by 78,021.35 hectares during 1980-2018. Rate of deforestation between 1980 and 2018 was 1,372.54 hectares per year. Therefore, the predicted results of 2037 year suggests that forest cover would decreases by 30,204.65 hectares within 19 years and also agricultural land would be increases by 30,693.91 hectares between 2018 and 2037. It approved helping concerned bodies that work on the forest better understand and address a tough land use system, and develop the ameliorated land use management strategies that can better protect forest degradation.
Source identification and health risks of nitrate contamination in shallow groundwater: A case study in Subei Lake basin
Authors: li zijun , Yang Qingchun , Xie Chuan , Lu Xingyu 
Published: July 2022

Abstract
Nitrate pollution in groundwater has become a global concern as it can affect the drinking water quality and human health. In this paper, an extensive hydrochemical investigation and health risk were performed in the Subei Lake basin where shallow groundwater is the main available drinking water resource for residents. The prevalent pollutant, nitrate (NO3-), has been identified based on descriptive statistical method and box and whisker plots, and most of the other parameters of groundwater samples meet water standards and can be used for drinking purpose. Nearly 23.53% of groundwater samples had the NO3- concentrations higher than the limit of 50 mg/L recommended by the World Health Organization, and the extremely high nitrate content (199 mg/L) was distributed around the Mukai Lake. Piper triangle diagram proposed that the dominated anions of hydrochemical types were observed with a gradual evolving trend from HCO3- to SO42- and Cl- with the increase of nitrate content. The results of correspondence analysis showed that agricultural activities were the most the possible source of nitrate contamination, while the higher content of other parameters in individual groundwater samples may be controlled by natural factors. The impacts of pollutant NO3- on human health were quantified using health risk assessment model, and results showed that the order of non-carcinogenic health risk values from oral exposure was Infants＞Children＞Adult males＞Adult females, corresponding to 65%, 53%, 41% and 35% of samples exceeding the accepted limit for nitrate associated health risk (HQ＞1), respectively. The detailed knowledge on groundwater quality characteristics obtained from this study can provide valuable reference for drinking water safety and groundwater pollution prevention.
Development of Wearable Multi-Lead ECG Measurement Device using Cubic Flocked Electrode
Authors: Takeshita Toshihiro , Yoshida Manabu , Takei Yusuke , Ouchi Atsushi , Hinoki Akinari , Uchida Hiroo , Kobayashi Takeshi 
Published: July 2022

Abstract
This paper describes the fabrication and fundamental evaluation of the cubic flocked electrode (CFE), which is a dry electrode that is fabricated using electrostatic flocking technology. The development of a wearable multi-lead electrocardiogram (ECG) measurement device using the CFE is also reported. To enable measurement of ECG signals with sufficient quality for medical applications, the occurrence of motion artifacts (MAs) is the most important problem to be overcome. Therefore, it is necessary to stabilize the contact between the patient’s skin and the dry electrode. Because the CFE developed in this work offers both contact stability and flexibility, it is expected to enable ECG measurements with low MA levels. In this study, it is demonstrated that the number of MAs caused by respiration can be reduced when the CFE contact is made at a contact pressure of approximately 500 Pa using MA evaluation equipment that was developed in-house. Additionally, a wearable multi-lead ECG is designed and fabricated based on this contact pressure (500 Pa). The results of the demonstration experiment show that the ECG measurements are successful to the same extent as a conventional medical device.
An Evidence-Based Approach to Covid-19 Pandemic Effects on Academics
Authors: Farrell Lynn , Latu Ioana , Linden Mark , Stefanova Vasilena , McCloskey Karen 
Published: July 2022

Abstract
We discuss our evidence-based approach to understanding and addressing the gendered impact of the pandemic on academics at Queen’s University Belfast, a research-intensive Russell Group UK University. The study was a collaboration between the University-wide Queen’s Gender Initiative, researchers, and Human Resources. A staff survey ran from 23 September until 30 October 2020, assessing academic productivity and personal factors including caring responsibilities, wellbeing, and time spent working. Data from 537 academics showed that multiple challenges were experienced with most of the day spent on work and caregiving tasks. The majority of worktime comprised teaching, at a cost to research productivity and personal wellbeing. These patterns were accentuated for female academics. From this holistic approach to understanding academics’ challenges, recommendations were presented to the University’s Executive Board and other high-level institutional committees. An Action Plan of sustainable solutions designed to mitigate the pandemic effect focused on promotion, research, workload support, and wellbeing. Furthermore, the findings directly informed policies to enhance working life, particularly in new models of flexible working. In summary, we report methodology to integrate research and centralized efforts to address the pandemic’s impact on academics, using a gender lens and incorporating complementarity of work, home-life and wellbeing.
Benefit of Blue Carbon Stocks in a coastal Jazan ecosystem under land use dynamic
Authors: El-Hamid Hazem Abd , Eid Ebrahem M. , El-Morsy Mohamed H.E. , Osman Hanan E.M. , Keshta Amr E. 
Published: July 2022

Abstract
Coastal ecosystems are characterized by high content of soil carbon storage; however, they experience severe land conversions in the past decades. The current study aims to examine how different land use/land cover (LU/LC) impact carbon stock in coastal ecosystem along Jazan coast, Saudi Arabia. In this study, impacts of LU/LC on carbon stocks in the coastal zone of Jazan, Saudi Arabia in 2009, 2013, and 2021 were assessed. Also, the LU/LC dynamics were evaluated using data provided by the land use dynamic model. The carbon stocks were modelled based on LU/LC using the InVEST program. Our study results showed that the decrease in mangroves from 2013 to 2021 reflects the high atmospheric emissions of carbon dioxide (CO2). Also, the increase in built-up areas might negatively impact total carbon stock. The estimated carbon stocks for the coastal zone of Jazan biome were 7279027.42 Mg C in 2009 (1Mg = 106 g). It decreased to 2827817.84 Mg C in 2013, with a total loss of –4450675.40 Mg C, and an average of annual loss of –1112669 Mg C in the study period with net value of –461240790.53 US$. On the other hand, the total estimated carbon stock was increased from 2013 to 2021 with a 3772968.31 Mg C in 2021 (a total gain 944840.87 Mg C). This study area should receive new public policies focusing on the recovery and conservation of environmental quality and climate change mitigation, by considering the socioeconomic and environmental importance of that basin in the national context.
Innovative approach with harmonic modes and finite element modeling for the nonlinear dynamic analysis of a suspension bridge
Authors: Yi Hui , Siu-seong Law , Guo Kunpeng , Min Liu 
Published: July 2022

Abstract
The non-linear characteristics of a general multiple degrees-of-freedom suspension bridge under harmonic excitation are studied with an innovative approach consisting of the harmonic modes, the finite element modeling and the Incremental Harmonic Balance method. The geometric non-linearity induced by large amplitude vibration is considered. The harmonic mode and mean kinetic energy of the system are proposed to describe the non-linear responses. The harmonic mode can be expressed as a linear combination of different linearized system modes. The resonance responses of the structure are characterized with the participation ratio of these system modes. Its composition under harmonic excitations can easily be described in terms of the different harmonic mode shapes and then the system modes. The proposed method is further applied to analyze, in detail, the properties of the harmonic modes and the evolution of the steady state non-linear responses with variations in the excitation frequency.
An Enduring In vitro Wound Healing Phase Recipient by Bioactive Glass- Graphene Oxide Nanocomposites
Authors: Nandhakumar N. Manjubaashini , T T. Daniel Thangaduari , Sundaram Senthilarasu , Roy Anurag , S Balakumar 
Published: July 2022

Abstract
Bioactive glass (BG) is intensely interested in soft tissue engineering because of its biocompatibility and bonding potential to increase fibroblast cell proliferation, growth factors, and granulation tissue development. The proposed BG with and without sodium (Na) was prepared using the sol-gel method for wound healing studies. The BG/graphene oxide (GO) and BG (Na-free)/GO nanocomposites were investigated against fibroblast L929 cells in vitro; the 45S5 BG nanocomposites exhibited desired cell viability (80%), cell proliferation (30%), cell migration (25%), metabolic activity, and wound contraction due to extracellular matrix (ECM) production and enhanced protein release by fibroblast cells. Additionally, the antioxidant assays for BG, BG (Na-free), GO, and BG/GO, BG (Na-free)/GO were evaluated for effective wound healing with reduced inflammation sites on the wound area, which was assessed by the (2,2-diphenyl-1-picryl-hydrazyl-hydrate) (DPPH) assay with 80% radical scavenging activity, confirming their anti-inflammation and improved wound healing properties.
The knowledge of Polish pregnant and lactating women about the risk factors and health consequences of obesity for mother and child
Authors: Maćków Monika 
Published: July 2022

Abstract
Background: Obesity is a chronic disease that affects all populations and age groups. The last decade has seen an increase in the incidence of overweight and obesity in women, also during pregnancy. Obesity in a woman who is expecting a baby can have serious health consequences for both her and the fetus, such as: hypertension, diabetes and other non-infectious diseases.Methods: The study was approved by a total of 232 women, including 120 pregnant and 112 lactating women aged 19-42. The study group consisted of women in the second and third trimesters of pregnancy, breastfeeding and mixed method (breastfeeding and milk replacers). A specially constructed questionnaire consisting of 10 questions was used in the study. Microsoft Excel 2010 and the SPSS 13.3 statistical program were used for the calculations.Results: Among pregnant women, 83.3% of them, and 50% during lactation, did not know the answer to the question of how the Body Mass Index (BMI) is calculated. Women expecting a baby were more likely to mention pre-eclampsia and gestational diabetes as consequences of overweight and obesity in a pregnant woman. Lactating women more often indicated breastfeeding as a factor protecting their child against obesity.Conclusion: The study shows that it is necessary to thoroughly educate pregnant and lactating women and those planning pregnancy about the risk factors and complications of obesity, especially during pregnancy, because it can affect both the health of the woman and the health of the child, including his body weight, which determines the emergence of many diseases in the future.