bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Bahan Ajar Berbasis Sosio Scientific Issue pada Materi Pencemaran Lingkungan untuk Meningkatkan Kemampuan Analitis Siswa
Authors: Adumiranti Yuninda , Widyaningrum Retno 
Published: December 2022

Semakin majunnya pendidikan menuntut siswa untuk memiliki kemampuan berpikir lebih tinggi. Salah satu kemampuan yang harus dimiliki siswa adalah kemampuan analitis. Pendekatan socioscientific issue dapat meningkatkan berpikir tinggi dengan menyelesaikan masalah. Pada pengamatan bahan ajar terdapat beberapa komponen yang belum lengkap. Maka perlu adanya pengembangan bahan ajar pada tema pencemaran lingkungan untuk meningkatkan kemampuan analitis.Penelitian ini bertujuan untuk (1) mengetahui validitas dan reliabitas bahan ajar socio scientific issue, (2) Penerapan bahan ajar socioscientific issue dan (3) keefektifan bahan ajar socioscientific issue dalam meningkatkan kemampuan berpikir analitis siswa. Penelitian ini merupakan penelitian Research and Development, dengan melakukan beberapa langkah dari model penelitian Brog and Gall. Pada hasil validasi dan reliabilitas, bahan ajar dihasilkan bahan ajar yang valid dan reliabitas. Pada keterlaksanaan dianalisis dengan mengakumulasi persentase respon observer dan juga siswa untuk melihat keterlaksanaan dari bahan ajar. Hasil akhir observer, bahan ajar dikategorikan keterlaksanaan yaitu 67% menyatakan cukup terlaksana dan 33% menyatakan terlaksana dengan baik. Keefektifan bahan ajar dapat dilihat dari hasil akhir rata-rata nilai N Gain sebesar 0,5625. Dengan hasil tersebut, taraf efektifitas bahan ajar dikategorikan sedang. Sedangkan pada hasil setiap indikator kemampuan analitis mengalami peningkatan.
Analisis Respon Pembelajaran Daring pada Era Pandemi Covid-19 terhadap Motivasi dan Minat Belajar Mahasiswa
Authors: Martiwi Erlyza , Ekapti Rahmi Faradisya 
Published: December 2022

Penelitian ini mempunyai tujuan untuk menganalisis dan menjelaskan kondisi serta kendala yang dialami terkait minat dan belajar mahasiswa pada masa pandemi Covid-19. Pada penelitian ini menggunakan metode kuantitatif yaitu menggunakan studi kasus. Adapun teknik yang digunakan adalah teknik survey, survey yang dibuat bertujuan untuk mengungkap secara detail tentang motivasi mahasiswa dalam pembelajaran daring selama masa pandemi Covid-19. Penelitian ini dilaksanakan pada 20-25 April 2021 dengan mengajukan 13 pertanyaan. Penelitian ini mengambil sampel responden secara random pada mahasiswa angkatan 2018 dari 5 perguruan tinggi yang berdomisili di Jawa Timur. Kuesioner tersebut dibagikan kepada responden melalui bentuk google form. Kemudian data yang sudah didapat dianalisis dan dihitung jumlah presentasenya kemudian dilakukan uji validitas item dilakukan dengan menggunakan korelasi product moment dengan software SPSS dengan hasil N= 40, nilai f.hitung > f.tabel (0,312) dan nilai sig. > nilai sig. α (0,05), sedangkan uji reliabilitas instrumen kuesioner dilakukan dengan menggunakan teknik analisis Cronbach's Alfa dengan hasil 0,657. Dari hal tersebut pembelajaran daring bisa menjadi pertimbangan untuk memperhatikan kondisi dan solusi minat serta motivasi belajar mahasiswa.
Meningkatkan Kemampuan Berpikir Rasional Peserta Didik Melalui Model Pembelajaran Children Learning In Science (CLIS) Berbantuan Mind Mapping
Authors: Zahro Addiliya Vida Dewi , Hadi Sofwan 
Published: December 2022

Semakin majunya Ilmu Pengetahuan dan Teknologi (IPTEK) membuat dunia pendidikan harus mempersiapkan sumber daya manusia yang memiliki kemampuan berpikir dalam menyelesaikan permasalahan yang berkembang di sekitarnya. Salah satu kemampuan yang perlu dikembangkan yaitu kemampuan berpikir rasional. Tujuan dari penelitian ini adalah mengetahui efektivitas model pembelajaran Children Learning In Science (CLIS) berbantuan mind mapping untuk meningkatkan kemampuan berpikir rasional peserta didik kelas VII SMP Negeri 1 Jenangan. Metode penelitian yang digunakan yaitu dengan pendekatan kuantitatif dan jenispenelitian eksperimen dengan desain Quasi Eksperimental. Sampel penelitian yang digunakan berjumlah 30 siswa. Pengumpulan data dilakukan melalui tes uraian. Data hasil penelitian di analisis menggunakan deskriptif kuantitatif kemudian dilanjutkan dengan statistik inferensial setelah dilakukan uji pra syarat. Berdasarkan hasil olah data yang telah dilakukan diketahui bahwa terdapat perbedaan kemampuan berpikir rasional di kelas eksperimen dan kontrol. Penerapan model pembelajaran Children Learning In Science (CLIS) berbantuan mind mapping pada kelas eksperimen lebih baik daripada kelas kontrol dengan model direct instruction. Sehingga model pembelajaran Children Learning In Science (CLIS) berbantuan mind mapping efektif dalam meningkatkan kemampuan berpikir rasional. Hal ini terjadi karena proses pembelajaran yang berpusat pada peserta didik dan mengajak peserta didik untuk aktif dalam mengembangkan ide yang dimiliki dalam menyelesaikan permasalahan.
Efektivitas Model Pembelajaran Think Talk Write (TTW) Berbantuan Web Liveworksheet Terhadap Kemampuan Menyelesaikan Masalah
Authors: Hidayah Umi Nur Kholifah , Arif Syaiful 
Published: December 2022

Kemampuan menyelesaikan masalah adalah upaya mencari jalan keluar dari suatu kesulitan untuk mencapai suatu tujuan yang tidak dapat dicapai dengan segera. saat peserta didik menghadapi tugas yang menantang,peserta didik wajib bisa bekerja keras buat bisa menuntaskan tugas yang sudah diberikan Penelitian ini bertujuan (1) untuk mengidentifikasi keterlaksanaan model pembelajaran Think Talk Write, (2) mengidentifikasi aktivitas siswa yang mengikuti pembelajaran Think Talk Write dan (3) mengidentifikasi efektivitas dari model pembelajaran terhadap kemampuan menyelesaikan masalah. Penelitian ini menggunakan penelitian kuantitatif eksperimen dengan teknik pengumpulan data melalui tes dan observasi. Data yang diperoleh dianalisis dengan menggunakan statistik deskriptif dan analisis statistik dengan menggunakan uji t test yang sebelumnya telah dilakukan uji normalitas dan uji homogenitas. Sampel penelitian diambil dari kelas VIII di MTsN 2 Ponorogo dengan menggunakan 2 kelas sebagai sample nya yakni kelas VIII C untuk kelas eksperimen dan kelas VIII D untuk kelas kontrol. Hasil penelitian menunjukkan bahwa (1) pelaksanaan pembelajaran dengan menggunakan model pembelajaran Think Talk Write sudah berjalan sesuai dengan indikator dan sintaks, (2) aktivitas siswa yang mengikuti pembelajaran yang menggunakan model pembelajaran Think Talk Write juga sangat baik, dan (3) untuk model pembelajaran Think Talk Write efektif terhadap kemampuan menyelesaikan masalah. Adanya perbedaan efektivitas antara model pembelajaran Think Talk Write dan model pembelajaran konvensional dibuktikan dengan berdasarkan uji T dengan nilai signifikansi 0,00 <0,05.
Utilizing bull's eye fish processing frame waste to produce edible proteins and quality assessment of the recovered proteins
Authors: Baraiya Kirankumar Gopalbhai , Bojayanaik Manjanaik , Taral Pravinkumar Vaghabhai , Surasani Vijay Kumar Reddy , Krishnamoorthy Elavarasan , Shetty Veena 
Published: December 2022

Abstract
With an aim to utilize the waste generated from Bull's eye (Priacanthus hamrur) fish processing, proteins were extracted from this waste using the pH shift method. The properties of extracted proteins were studied in detail. During the protein solubility measurement, maximum solubilisation was found at pH 3.0 (13.10 mg/mL) on the acidic side and pH 11.0 (14.25 mg/mL) on the alkaline side with a total yield of 51.62 ± 0.23 and 45.42 ± 0.29 (%), respectively. The variables tested in this study showed a significant effect on protein solubility (p < 0.05). The protein content of the isolates extracted from the waste was 23.80 ± 0.49 and 22.48 ± 0.39% for acid and alkali processed isolates, which was significantly higher than the mince (19.46 ± 0.67%). Processing of Bull’s eye proteins caused a significant reduction in its pigments, lipids and myoglobin content (p < 0.05). Proteins processed using alkali had significantly higher values for foaming stability, water holding capacity, and emulsion capacity than proteins extracted using acid. An overall assessment indicated that protein isolates obtained using alkali extraction were better in terms of textural attributes, gelling ability and amino acid profile than protein extracted using the acid process.
A Mathematical Model for Forecasting Global Demographic Dynamics in the Age of Intelligent Machines
Authors: Sadovnichy Viktor , Akaev Askar , Korotayev Andrey 
Published: December 2022

Abstract
The article deals with the global demographic transition and phenomenological models of demographic dynamics by Sergey Kapitsa and Boris Dolgonosov developed on the basis of the principles of demographic and informational imperatives. The technological imperative is analyzed, which is intermediate between the first two. The authors propose a new mathematical model for forecasting demographic dynamics in the era of widespread use of intelligent machines. The model has been developed on the basis of the demographic model of Sergey Kapitza and equations for the production of useful information in human society, based on the assumption of Sergey Kuznets about technological progress. Calculations made using this model show that the population of the Earth, having reached a maximum value c. 8.7 billion in 2060, will then begin to decline steadily and by 2100 will not exceed 8.3 billion.
Can width of lower tongue base preoperative sonography measurements predict hypoxemia during esophagogastroduodenoscopy under sedation?
Authors: Wu Hao , Xia Min , Chen Xu , Wang Sheng , Zhang Wei 
Published: December 2022

Abstract
Background: The most common complication during esophagogastroduodenoscopy (EGD) under sedation is a decrease in pulse oxygen saturation (SpO2) and even the development of hypoxemia. The width of the lower tongue base measured by ultrasound is considered to be a significant predictor of the presence and severity of obstructive sleep apnea syndrome (OSAS). This study aimed to observe the capability of the width of the lower tongue base measured by ultrasound to predict hypoxemia during EGD under sedation.
Methods: Adult patients undergoing EGD under sedation at our hospital after assessment in the anesthesia clinic were enrolled in the study. The width of the lower tongue base was measured as the distance between the lingual arteries (DLA) on both sides of the inferior lateral margin of the tongue by ultrasound. Beside weight and height were recorded. The primary outcome was hypoxemia defined as the SpO2 < 90% at any time during EGD under sedation.
Results: A total of 304 patients were successfully included, and hypoxemia was reported in 32 patients. The DLA prediction criterion for hypoxemia was ＞31 mm. The DLA was correlated with hypoxemia (Spearman correlation coefficient, 0.455; P <0.001) and owned the highest area under the receiver operating characteristic curve (0.927; 99% CI, 0.891 to 0.953, compared with that of the other predictors, P < 0.001) with hypoxemia.
Conclusions: The width of the lower tongue base, measured as the DLA by ultrasound examination can be used to predict the risk of hypoxemia during EGD under sedation effectively. In addition, compared with BMI, DLA measured by ultrasound examination exhibits improved predictive capabilities.
Trial registration: ChiCTR, ChiCTR2000032940, 16/05/2020. https://www.chictr.org.cn/index.aspx
Clinical and sonographic improvement of developmental dysplasia of the hip: Analysis of 948 patients
Authors: Lankinen Vilma , Bakti Karim , Helminen Mika , Välipakka Jarmo , Laivuori Hannele , Hyvärinen Anna 
Published: December 2022

Abstract
Background: Developmental dysplasia of the hip is a common condition, which varies in severity. Abduction treatment is widely used to correct the development of the hips, but mild forms of DDH can also recover spontaneously. The purpose of this study was to evaluate factors affecting the rate of improvement of developmental dysplasia of the hip, and evaluate any risk factors slowing the process.
Material and methods: The study population consisted of patients diagnosed with DDH in Tampere University hospital in the years 1998-2018. Data was retrospectively collected and associations between clinical variables and rate of improvement were analyzed. Alpha angles were assessed monthly and associations between risk factors and improvement of alpha angles were studied. Total of 948 patients were included in the analysis.
Results: More sever first status of the hips was associated with faster improvement in dynamic ultrasound compared to milder DDH in univariate design in first 3 months of age, in the multivariable design Ortolani positivity was conversely associated with lower alpha angles in 1-month follow-up. Immediate abduction treatment was associated with faster recovery rate compared to delayed abduction or watchful waiting. Female sex and positive family history were associated with slower rate of improvement and lower alpha angles. In multivariable design, female sex, positive family history and treatment strategy remained statistically significant as initiation time of the treatment explained the first found association of clinical hip status and the recovery rate after 2 months of age.
Conclusion: Female sex and positive family history might be independent risk factors for slower recovery in DDH before six months of age. These children might need special attention in their follow-up plans and abduction treatment.
Particle swarm optimization with dynamic nonlinear inertia weight and population-topology selection strategy for brain functional parcellation from fMRI data
Authors: zhao xuewu , Wu Ning , Liu Chaohui , Li Lingling , Ji Junzhong 
Published: December 2022

Abstract

The brain functional parcellation based on functional magnetic resonance imaging (fMRI) data is a research hotspot in the field of brain science. However, due to the large dimension and low signal-to-noise ratio of fMRI data, the majority of current parcellation methods are ill-equipped to handle it, exhibiting weak search capabilities and poor functional parcellation structures. To address the issues, this paper provides a novel brain functional parcellation method based on particle swarm optimization (PSO) with dynamic nonlinear inertia weight and population-topology selection strategy (called DPPSO). In DPPSO, a functional correlation matrix derived from preprocessed fMRI data is mapped into a low-dimensional space with spectral mapping. Then, DPPSO employs an enhanced PSO to search cluster centers that are encoded as particle positions, where a dynamic nonlinear inertia weight is adopted to balance the global search and the local search, and a population-topology selection strategy for individual historical optimal position in the speed update formula is employed to increase the diversity of particle swarms. Finally, a functional parcellation result is obtained by mapping the cluster labels of low-dimensional data to the corresponding voxels. The experimental results on real fMRI data demonstrate that DPPSO has a stronger search capability and achieves a more better functional parcellation in terms of spatial structures and functional consistency.
Transcranial Direct Current Stimulation as Treatment for Major Depression in a Home Treatment Setting (HomeDC Trial): Study Design and Methodology of a Double-blind, Placebo-controlled Pilotstudy
Authors: Kumpf Ulrike , Ezim Harry , Stadler Matthias , Burkhardt Gerrit , Palm Ulrich , Dechantsreiter Esther , Padberg Frank 
Published: December 2022

Abstract
Introduction

Transcranial direct current stimulation (tDCS) of prefrontal cortex regions has been reported to exert therapeutic effects in major depressive disorder (MDD). Due to its beneficial safety profile, its easy mode of application and its cost-effectiveness, tDCS has recently been proposed for treatment at home, which would offer new chances for regionally wide spread and long-term application. However, tDCS at home has to meet new methodological challenges of handling and adherence, and data from randomized controlled trials (RCT) investigating this mode of application are still lacking. In this pilot RCT, we therefore investigate feasibility, safety and effectiveness of a new tDCS application set-up in MDD.

Methods and analysis

The HomeDC trial will be conducted as a double-blind, placebo-controlled, parallel-group design trial. Thirty-two patients with MDD will be randomized to active or sham tDCS. Patients will self-administer prefrontal tDCS for 6 weeks. Active tDCS will be conducted with anode over F3, cathode over F4, for 5 sessions/week, with a duration of 30min/day and 2mA stimulation intensity, whereas sham tDCS follows the identical protocol in electrode montage and timing but with ramp-in and ramp-out periods only without intermittent stimulation. Both conditions will be administered as monotherapy or adjunctive treatment to a stable dose of antidepressant medication. Feasibility, effectiveness and safety will be assessed, and adjunctive fMRI and e-field modelling will be conducted at baseline.

Discussion

For the HomeDC trial, technical requirements of a placebo-controlled trial in a home-based treatment setting with tDCS have been established. It addresses the crucial points of a home-based treatment approach with tDCS: uniform electrode positioning and frequent monitoring of stimulation parameters and adherence, ensuring an appropriate home treatment environment. This study will allow identifying constraints and further critical topics of this novel mode of application.

Trial Registration

www.clinicaltrials.gov. Trial registration number: NCT05172505. Registration date: 12/13/2021, https://clinicaltrials.gov/ct2/show/NCT05172505
The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress ： a retro- prospective study
Authors: Pan Ting , Gao Jie , Cai Xinghua , Zhang Huihui , Lu Jun , Lei Tao 
Published: December 2022

Abstract
Background: The conclusion between Connecting peptide (C-peptide) and diabetic chronic complication was controversial. The purpose of this study is to explore the possible association between average C-peptide with diabetic retinopathy (DR) progression in Chinese patients with type 2 diabetes.
Methods: This is a retro-prospective study. 622 patients with type 2 diabetes were included. DR was evaluated using non-mydriatic fundusphotography and DR progression was defined as any deterioration of either eye. Fasting and postprandial c-peptide levels were assayed at baseline and follow-up period. Differences between continuous variables were compared using the Mann–Whitney U test; and categorical variables were analyzed by the chi-square test. Correlation between parameters and 30-minute postprandial C-peptide were determined by Spearman correlation test. The relationship between C-peptide and DR progression was evaluated by multivariable binary logistic regression. Two-tailed P-values < 0.05 were regarded as statistically significant.
Results: DR was present in 162 (26.0%) patients at baseline, and 26.4% of patients were found progression of DR at follow-up. Patients with progression of DR had lower average levels of 30-minute postprandial C-peptide (2.01 ng/ml vs. 2.6 ng/ml, p = 0.015) and 120-minute postprandial C-peptide (3.17 ng/ml vs. 3.92 ng/ml, p < 0.029), as well as average increment of 30-minute (0.41 ng/ml vs. 0.64 ng/ml, p = 0.015) and 120-minute postprandial C-peptide (1.48 ng/ml vs. 1.93 ng/ml, p < 0.017), less than those without DR aggravation. Multivariate logistic regression analysis determined that 30-minute postprandial C-peptide and its increment were related to reduced odds ratios for DR progression (odds ratios [OR] = 0.83 and 0.73, respectively).
Conclusions: Our results suggest that the Average 30-minute post-prandial C-peptide and increment were negatively correlated with DR progression, which further demonstrates the importance to preserve β-cell residual function in the prevention for DR progression.
Trial registration: Not applicable.
Effect of NaClO and ClO2 on the bacterial properties in a reclaimed water distribution system: efficiency and mechanisms
Authors: Jia Shichao , Tian Yimei , Song Yarong , Zhang Haiya , Kang Mengxin , Guo Hao , Chen Haolin 
Published: December 2022

Abstract
Extensively application of reclaimed water alleviated water scarcity obviously. While, bacterial proliferation in reclaimed water distribution systems (RWDSs) poses a threat to water safety. Disinfection is the most common method to control microbial growth. The present study investigated the efficiency and mechanisms of two widely used disinfectants: sodium hypochlorite (NaClO) and chlorine dioxide (ClO2) on the bacterial community and cell integrity in effluents of RWDSs through high-throughput sequencing (Hiseq) and flow cytometry respectively. Results showed that a low disinfectant dose (1 mg/L) did not change the bacterial community basically, while an intermediate disinfectant dose (2 mg/L) reduced the biodiversity significantly. However, some tolerant species survived and multiplied in high disinfectant environments (4 mg/L). Additionally, the effect of disinfection on bacterial properties varied between effluents and biofilm, with changes in the abundance, bacterial community, and biodiversity. Results of flow cytometry showed that NaClO disturbed live bacterial cells rapidly, while ClO2 caused greater damage, stripping the bacterial membrane and exposing the cytoplasm. This research will provide valuable information for assessing the disinfection efficiency, biological stability control, and microbial risk management of reclaimed water supply systems.
Physaria fendleri FAD3-1 overexpression increases ɑ-linolenic acid content in camelina seeds
Authors: Park Mid-Eum , Choi Hyun-A , Kim Hyun Uk 
Published: December 2022

Abstract
Camelina (Camelina sativa) is an oil crop with a short growing period, resistance to drought and cold, low fertilizer requirements, and can be transformed using floral dipping. Camelina seeds have a high content of polyunsaturated fatty acids, especially ɑ-linolenic acid (ALA) at 32–38%. ALA is an omega-3 fatty acid (FA) that is a substrate for eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the human body. In this study, ALA content was further enhanced by seed-specific expression of Physaria fendleri (Pf) FAD3-1 in camelina. When PfFAD3-1 was introduced into camelina using the seed-specific glycinin promoter, ALA content increased by 48% in T2 seeds and 50% in T3 seeds. In addition, the weight and size of seeds increased. The expression of FA metabolism related genes in GlyP:PfFAD3-1 transgenic camelina was different than that in the wild type, in which the expression of Camelina sativa (Cs) FAD2 decreased and that of CsFAD3 increased. In summary, we developed a high omega-3 FA containing camelina with up to 50% ALA content by introducing PfFAD3-1. This line can be used for genetic engineering to obtain EPA and DHA from seeds.