bluuebunny/crossref_metadata_2025_split huggingface dataset:
S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia
Authors: Oh Chang-ki , Dolatabadi Nima , Cieplak Piotr , Diaz-Meco Maria T. , Moscat Jorge , Nolan John P. , Nakamura Tomohiro , Lipton Stuart A. 
Published: February 2022

Dysregulation of autophagic pathways leads to accumulation of abnormal proteins and damaged organelles in many neurodegenerative disorders, including Parkinson's disease (PD) and Lewy body dementia (LBD). Autophagy-related dysfunction may also trigger secretion and spread of misfolded proteins, such as α-synuclein (α-syn), the major misfolded protein found in PD/LBD. However, the mechanism underlying these phenomena remains largely unknown. Here, we used cell-based models, including human induced pluripotent stem cell-derived neurons, CRISPR/Cas9 technology, and male transgenic PD/LBD mice, plus vetting in human postmortem brains (both male and female). We provide mechanistic insight into this pathologic pathway. We find that aberrant S-nitrosylation of the autophagic adaptor protein p62 causes inhibition of autophagic flux and intracellular buildup of misfolded proteins, with consequent secretion resulting in cell-to-cell spread. Thus, our data show that pathologic protein S-nitrosylation of p62 represents a critical factor not only for autophagic inhibition and demise of individual neurons, but also for α-syn release and spread of disease throughout the nervous system.SIGNIFICANCE STATEMENTIn Parkinson's disease and Lewy body dementia, dysfunctional autophagy contributes to accumulation and spread of aggregated α-synuclein. Here, we provide evidence that protein S-nitrosylation of p62 inhibits autophagic flux, contributing to α-synuclein aggregation and spread.
Analysis of Creativity and Attitudes Caring The Environment of Junior High School Students: Study of Environmental Physics Learning Using Learning Modules
Authors: Amelia T. , Jumini S. , Khoiri A. 
Published: February 2022

The natural and socio-cultural environment of the Wonosobo community has various potentials that can be explored and developed to support the science learning process. Pranotomongso is a form of culture used by farmers to cultivate nature. This study aims to determine the application of ethnoscience-based integrated science learning to foster environmental awareness and student creativity. This research is a quantitative study using the True Experimental method, with a Posttest Only Control Design, the sampling technique is random sampling. The instruments used for data collection were tests and questionnaires to measure creativity and environmental awareness. The data analysis technique used one-party t-test. The results showed that ethnoscience-based integrated science learning can foster environmental awareness and student creativity and can improve environmental care and student creativity in ethnoscience-based integrated science learning, in the medium category. This research is very useful in showing how science works in society, and it is more applicable.Â Â Â Â Â
Articular spacers in two-stage revision arthroplasty for prosthetic joint infection of the hip and the knee
Authors: Craig Andy , King S W , van Duren B H , Veysi V T , Jain S , Palan J 
Published: February 2022

Use of articular antibiotic-eluting cement spacers during two-stage revision arthroplasty for prosthetic joint infection (PJI) is a long-established and proven adjunctive technique during first-stage surgery. Articular spacers come in many forms, either static or dynamic. The authors present an instructional review of current evidence regarding their use.
A total of 45 studies (for spacer use in PJI involving either hip or knee) were analysed for data regarding eradication rate, functional outcomes, mechanical complications and the impact on second-stage surgery. A large number of case series and retrospective cohort studies were retrieved, with only a small number of prospective studies (2).
High levels of infection eradication were commonly reported (>80%). Outcome scores were commonly reported as indicating good-to-excellent function and pain levels. Second-stage procedures were often not required when dynamic spacers were used. Static spacers were associated with more mechanical complications in both the hip and the knee. In the hip, dynamic spacers were more commonly associated with instability compared to static spacers. Consideration should be given to the use of dual-mobility or constrained definitive acetabular components in these cases at second-stage surgery.
The use of antibiotic-eluting polymethylmethacrylate articular spacers in two-stage revision for PJI of hip and knee arthroplasty achieves a high rate of infection eradication. Dynamic spacers may confer a variety of benefits compared to static spacers, with a similar rate of infection eradication.
La desaparición del pueblo coxoh de Escuintenango, Chiapas. Siglos XVI-XIX
Authors: Martínez González Alma Rosa 
Published: February 2022

Este artículo pretende exponer el porqué de la desaparición de Escuintenango, en Chiapas, México, un pueblo maya de habla coxoh. Dicha población, cuya importancia residía principalmente en ser parte del Camino Real de Guatemala –imprescindible para la comunicación de la época–, desapareció dejando solo ruinas entre campos de ganado vacuno. Este trabajo es el resultado del estudio de documentos de los siglos XVI al XIX hallados en el Archivo Histórico Diocesano de San Cristóbal de Las Casas. La documentación reveló los problemas demográficos de Escuintenango y la continua disposición de las autoridades por evitar su desaparición. A partir de esta investigación se pudo concluir que su desaparición fue un proceso de larga duración que respondió a varios factores, entre los cuales están: lo inhóspito de la zona del asentamiento por las constantes inundaciones, la migración de sus habitantes a lugares más prósperos, como el Soconusco, el creciente auge de las estancias ganaderas, las epidemias y la explotación laboral.
Uso de aloinjerto estructural e infecciones posquirúrgicas
Authors: Jorge Fernando Daniel , Varaona José María , Basso Mariela 
Published: February 2022

Introducción: El uso de aloinjertos conlleva el riesgo de complicaciones. Una de las más frecuentes es la infección. Un importante factor de riesgo de infección con el uso de injertos óseos es la transmisión de gérmenes a través del injerto. Nuestros objetivos fueron determinar si existe una relación entre la posible contaminación de los injertos de este Banco y las infecciones posquirúrgicas; demostrar cómo la selección del donante, la procuración y el procesado del injerto adecuados disminuyen la tasa de contaminación e informar otras complicaciones relacionadas con la calidad del injerto.
Materiales y Métodos: Se seleccionaron pacientes que recibieron injerto óseo estructural de nuestro Banco. Todos los injertos fueron estudiados microbiológicamente. Se revisaron las historias clínicas, y los pacientes fueron sometidos a una anamnesis y un examen físico, y se les tomaron radiografías para detectar infección y otras complicaciones. Se utilizó la Escala de Osteointegración ISOLS.
Resultados: En ninguno de los injertos, se detectó contaminación. Se identificó un caso (7,7%) de infección por Klebsiella pneumoniae productora de carbapenemasas y 3 casos (23%) de falta de integración. La integración fue entre buena y excelente en el 77% de los casos, satisfactoria en el 8% y pobre en el 15%. No hubo otras complicaciones.
Conclusiones: Existe riesgo de transmisión de infecciones con el aloinjerto estructural. Los criterios reglados de selección de donantes y el control de los procedimientos dentro del banco de huesos disminuyen el riesgo de infección por contaminación del injerto y de otras complicaciones relacionadas con la calidad del injerto.
Variantes anatómicas del tubérculo de Lister. Presentación de una clasificación imagenológica y su utilidad clínica
Authors: Sala Matías , González Juan Francisco 
Published: February 2022

Objetivo: Evaluar, en forma retrospectiva, las diferentes variantes de los tubérculos de Lister y el extensor largo del pulgar en imágenes de resonancia magnética de muñecas y, sobre la base de dichos hallazgos, proponer variables a la clasificación.
Materiales y Métodos: Estudio retrospectivo utilizando imágenes de resonancia magnética entre el 1 de marzo y el 10 de noviembre de 2019. Se incluyeron imágenes de muñeca de pacientes sanos (cortes axiales, sagitales y coronales de 1 mm de espesor), >18 años, sin fractura de muñeca o del carpo, previa o actual, y se excluyó a quienes no cumplían estos criterios. Se analizaron el tubérculo de Lister, la altura de los picos radial y cubital, el ángulo, la longitud del tubérculo, la profundidad de los valles y la altura del tabique. Se evaluó el extensor largo del pulgar analizando la altura, el espesor, la superficie y la presencia o no inflamaciónasociada.
Resultados: Se analizaron 500 imágenes de muñeca, y se obtuvieron 11 subtipos de tubérculo de Lister: 411 tipo 1, 58 tipo 2 y 26 tipo 3. Dentro de estos, el más frecuente fue el tipo 1B. El 26,6% tenía inflamación asintomática en el tercero y cuarto compartimento.
Conclusiones: El tubérculo de Lister es importante en muchos procedimientos y sirve como punto de referencia anatómico; por lo tanto, es preciso conocer su patrón más frecuente y sus variantes anatómicas. Proponemos una ampliación de la clasificación, adicionando nuevos tipos de tubérculo por conocer y su relación con el extensor largo del pulgar.
Prevención, manejo y seguimiento de las lesiones de la arteria vertebral. Conocimiento actual de los cirujanos de columna de la Argentina
Authors: Illanes Cristian , Cubile Mariano , Solsona Sebastián , Herrero Verónica , Medina Daniela , Estay Ayelén 
Published: February 2022

Introducción: La lesión de la arteria vertebral es un evento grave. El objetivo del estudio fue evaluar el grado de conocimiento de los cirujanos de columna en la Argentina sobre las medidas diagnósticas y terapéuticas de la lesión de la arteria vertebral.
Materiales y Métodos: Se realizó un estudio descriptivo observacional mediante una encuesta difundida a través de la AANC y la SAPCV.
Resultados: Se recibieron157 respuestas. El 47,4% considera relevante evaluar la anatomía de la arteria vertebral en todo tipo de patología mediante métodos angiográficos. La mitad de los encuestados diagnosticó una variante anatómica de la arteria. El 29,2% manifestó haber tenido en su práctica una lesión de la arteria. Solo el 35% tiene un protocolo de acción para el manejo de este evento adverso. El 77% adopta como primera medida el taponamiento. En el seguimiento posquirúrgico, la mayoría estudia el estado final mediante métodos angiográficos. Alrededor del 10% procuraría instaurar alguna medida de profilaxis antitrombótica. El 76,6% dispone de Servicio de Hemodinamia con cirujano endovascular.
Conclusión: Esta complicación está subestimada. Menos de la mitad de los cirujanos utiliza, como rutina, herramientas de diagnóstico de posibles alteraciones anatómicas. No se han observado protocolos de manejo ni seguimiento de estas lesiones.
Colombia en las redes epistémicas transnacionales de eugenesia (1920-1940)
Authors: Olaya-Peláez Iván-Darío 
Published: February 2022

el “clima de ideas” que surgió en el mundo occidental en torno a la degeneración racial y la eugenesia como su solución condujo a la constitución de una red epistémica transnacional. Los jóvenes países latinoamericanos en la búsqueda de construir Estadosnaciones basados en la idea de “progreso” y “civilización” adhirieron este movimiento pues el futuro de la nación dependía de la buena constitución genética del pueblo. Por eso, entre 1920 y 1940 comenzó a constituirse un proyecto eugenésico panamericano el cual adoptaría políticas de control de la población para así producir el hombre americano “apto”. Aunque la eugenesia no se institucionalizó en Colombia, el país no estuvo ajeno al movimiento. Sus principios, recomendados por algunos expertos colombianos, impregnaron proyectos sociales y leyes públicas nacionales de inmigración y protección infantil. A través de la revisión de las actas de congresos especializados panamericanos, este artículo muestra la integración de los expertos colombianos a las redes epistémicas eugenésicas latinoamericanas y su participación en la puesta en marcha del proyecto eugenésico panamericano entre 1920 y 1940.
Case report of Laryngeal Amyloidosis: Unusual cause of hoarseness
Authors: Khamalrudin Noraimi , Mohamad Yunus Mohd Razif , Mat Baki Marina , Kin Foong Seong 
Published: February 2022

Background: Laryngeal amyloidosis is a rare pathology of the airway in which the diagnosis can only be made via tissue biopsy.Â We reported a case of laryngeal amyloidosis presenting with symptoms of hoarseness and voice fatigue.Case report: This is a case report of laryngeal amyloidosis in a middle-aged female patient who presented with hoarseness of voice. Upon obtaining a further history and performing a clinical examination, it was noted that the patient had a laryngeal mass. She underwent surgery, and the mass was histopathologically confirmed as laryngeal amyloidosis. She was successfully treated with a combination of surgical and medical treatment. This case presentation describes these rare pathological findings, their clinical manifestations, the histopathological and surgical diagnostic problems, treatment and patientâ€™s progress that we followed up till presence.Conclusion: Isolated laryngeal amyloidosis is a rare benign laryngeal tumor that is often presented with various symptoms depending on the tumor location and can even cause upper airway obstruction. It is a histological diagnosis confirmed by histopathological specimens that are stained with Congo red. Treatment of laryngeal amyloidosis includes symptomatic relief, surgical or even conservative treatment.Â
Pectoralis major myocutaneous flap for head and neck reconstruction: a case report
Authors: Oktahermoniza Oktahermoniza , Oktavenra Ari , Khambri Daan 
Published: February 2022

Introduction: Cancer surgery in the head and neck area generally causes a wide defect and usually cannot be closed primarily or by using the surrounding tissue, thus a flap is needed. There are several types of flaps, namely local flaps, pedicle flaps, and free flaps. Although the free flap is currently the gold standard for reconstruction of the head and neck in developing countries, the resources for a free flap in most healthcare center are still lacking, as well as the large number of patients with poor economic and nutritional status. Thus, the pectoralis major myocutaneous flap (PMMF) remains popularly used.CaseÂ Description: A 46-year-old male patient with squamous cell carcinoma in the neck area, underwent wide excision procedure and the surgical defect was reconstructed with a pectoralis major myocutaneous flap. Â The results of reconstruction with pectoralis major myocutaneous flap were viable, and were functionally and aesthetically acceptable. There are no postoperative complications such as hematoma or abscess observed.Conclusion: Pectoralis major myocutaneous flap was one of the main and easy to learn modalities for head and neck reconstruction surgery and it was acceptable functionally and aesthetically in situations where free flap could not be performed for one or many reasons.
Relationship of gallbladder histopathology towards types of stones in cholelithiasis patients at Universitas Sumatera Utara Hospital, Medan, Indonesia
Authors: Muhar Adi Muradi , Siregar Denny Rifsal , Prabisma Doddy 
Published: February 2022

Background: Cholelithiasis is a common disease of the gall bladder. It is estimated that around 10-15% of the population in western countries suffer from cholelithiasis. Types of gall bladder stones can be classified into cholesterol stones (containing cholesterol> 50%), mixed stones (containing 20-50% cholesterol), and pigment stones (containing cholesterol <20%). Cholelithiasis causes various histopathological changes in the gallbladder mucosa such as acute and chronic inflammation, Cholelithiasis, hyperplasia and carcinoma. The general objective of this study was to determine the histopathological relationship of the gallbladder to the type of stone in cholelithiasis patients at USU Hospital.Method: The design in this study was cross-sectional. The sample of this study was 49 samples of patients with cholelithiasis who underwent cholecystectomy either by open cholecystectomy or per-laparoscopic cholecystectomy at Universitas Sumatera Utara (USU) Hospital. Gallstones and gall bladder will be examined in the laboratory. Data analysis will use the chi-square test.Â Result: From 49 research samples found the most types of stones were mixed stones with 24 (49%) and histopathological results showed 18 examples (36.7%) were chronic inflammation. Based on the Chi-Square test found a significant relationship between the types of stones with histopathology of the gallbladder with a p-value of 0.001.Â Conclusion: There is a significant relationship between the type of stone with histopathology in patients with cholelithiasis.Â
Radiofrequency ablation for management of thyroid nodules: a case report
Authors: Yarsa Kristanto Yuli , Bellynda Monica 
Published: February 2022

Background: Thyroid nodules constitute a frequently seen clinical problem and the incidence of thyroid nodules has increased with the recently increased use of thyroid ultrasonography. Radiofrequency ablation (RFA) is an effective and safe method for treating benign thyroid nodules and recurrent thyroid cancers.Case Presentation: A 48 years old woman came to the surgical oncology clinic with the presence of a getting bigger, moves when the patient swallows, and painless mass on her neck since 20 years ago. The physical examination measured 5x5 cm mass, mobile on swallowing, no pain on palpation, and the laboratory examination shows a euthyroid state. Â The ultrasound result has revealed an enlargement of the right and left thyroid with increased echo intensity of parenchyma and increased vascularisation. This mass was concluded as struma nodus bilateral. The FNAB was follicular neoplasm, Bethesda system class 4. The patient underwent a single session RFA. RFA was performed employing transisthmic access using a 7 cm 18 gauge electrode-needle with a 1 cm active needle tip. The patient well tolerated the procedure and no adverse events were noted.Â Conclusion: Radiofrequency ablation for thyroid lesions is a safe and effective method for treating benign thyroid nodules and even recurrent thyroid cancers. Therefore, various factors, including serum TSH, clinical risk factor assessment, size of the nodule, ultrasound characteristics, patient preferences, and results of the FNA biopsy, should be considered to manage thyroid nodule.
The success rate of distal transradial access on invasive cardiology procedures: the first Indonesian experience
Authors: Lubis Leonardo , Yahya Achmad Fauzi , Melina Ananda Lisa , Wirata Gede , Lesmana Ronny , Nasution Gita Tiara , Purba Ambrosius 
Published: February 2022

Background:Â Distal transradial access (dTRA) in invasive cardiology procedures is becoming popular. It has greater potential and benefits than conventional transradial access (TRA) and transfemoral access (TFA) to reduce the risk of post-procedure complications and provide comfort to the patient and operator. This advantage is obtained from the distal radial artery located in the anatomical snuffbox that is more distal and superficial to bony foundation bearing, and anastomoses create the palmar arch. In Indonesia, the first invasive cardiology procedure using dTRA was performed at Hasan Sadikin Hospital.Aim: This study aims to determine the success rate of the distal radial artery access in invasive cardiology procedures at Hasan Sadikin General Hospital (RSHS).Methods:Â A quantitative study has been performed using 105 medical records of participants who had undergone invasive cardiology procedures via dTRA at RSHS from July 2017 to March 2020.Result:Â The study shows 97 patients successfully performed cannulation and sheath insertion, and 87 patients completed the procedure via dTRA. Conversion to other access was 13.33% and most of them were converted to TFA. A small number of post-procedure complications occurred in 3 patients (2.86%). There were no post-procedure complications such as major bleeding, radial artery occlusion and arteriovenous fistula.Conclusion:Â The tremendous success rate and the minimum vascular complications of dTRA in RSHS proved that dTRA is safe and feasible to be performed as the first choice on invasive cardiology procedures for Indonesian.
Use of smartphone-based self-monitoring blood glucose application in type 2 diabetes mellitus patients in Indonesia: A pre and post-test study
Authors: Kshanti Ida Ayu , Mokoagow Md Ikhsan , Rosandi Rulli , Epriliawati Marina , Nasarudin Jerry , Magfira Nadya 
Published: February 2022

Background: The utilization of technology in diabetes management, especially self-monitoring blood glucose (SMBG), is growing rapidly. However, the effectiveness of SMBG applications on the smartphone is not yet known. This study aims to assess the effectiveness of using a smartphone-based SMBG application in type 2 diabetes mellitus (T2DM) patients in the Indonesian population.Methods: This is a quasi-experimental (before and after) study conducted at three tertiary hospitals in Jakarta and Malang, Indonesia. Inclusion criteria were T2DM patients aged 18 years and above who have been familiar with performing SMBGÂ and manually record the results. All subjects were asked to use a smartphone-based SMBG application named Teman Diabetes application for six months, and patients' SMBG performance was assessed at the end of the study Bivariate analysis using T-test or with the Mann Whitney U test performed. Chi-square test is used to analyze the categorical with Risk Ratio (RR) and 95% Confidence Interval (CI). The p-value <0.05 (two-tailed) is considered statically meaningful.Results: From 100 patients enrolled in the study, 78 patients completed the follow-up. We found that the use of the SMBG application helped the subject overcome the difficulty in remembering to perform SMBG (p=0.004), helped change the subject's perception of the benefits of SMBG (p=0.049), improved the subject's diet pattern (p=0.006), and decreased the number of subjects who stopped performing SMBG due to self-perception of lack of benefit SMBG activity (p=0.049).Conclusions: The study found that using the SMBG application helps manage diabetes in T2DM patients.