bluuebunny/crossref_metadata_2025_split huggingface dataset:
A TDP-43 acetylation-mimic mutation that disrupts RNA-binding drives FTLD-like neurodegeneration in a mouse model of sporadic TDP-43 proteinopathy
Authors: Necarsulmer Julie , Simon Jeremy , Evangelista Baggio , Chen Youjun , Tian Xu , Nafees Sara , Gonzalez Ariana Marquez , Wang Ping , Ajit Deepa , Nikolova Viktoriya , Harper Kathryn , Ezzell Jennifer , Beltran Adriana , Moy Sheryl , Cohen Todd 
Published: November 2022

Abstract
TDP-43 proteinopathies including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis are neurodegenerative disorders characterized by aggregation and mislocalization of TDP-43 and subsequent neuronal dysfunction. Here, we developed an endogenous model of sporadic TDP-43 proteinopathy based on the principle that disease-associated TDP-43 acetylation at lysine 145 (K145) alters TDP-43 conformation, impairs RNA-binding capacity, and induces downstream mis-regulation of target genes. Expression of acetylation-mimic TDP-43K145Q resulted in stress-induced phase-separated TDP-43 foci and loss-of-TDP-43-function in mouse primary neurons and human induced pluripotent stem cell-derived neurons. Mice harboring the TDP-43K145Q mutation recapitulate key hallmarks of FTLD-TDP, including progressive TDP-43 phosphorylation and insolubility, mis-localization, transcriptomic and splicing alterations, and cognitive dysfunction. Our study suggests that TDP-43 acetylation drives neuronal dysfunction and cognitive decline through aberrant splicing and transcription of critical genes, many of which modulate synaptic plasticity and stress response signaling. Unraveling this neurodegenerative cascade provides a new paradigm to interrogate FTLD pathogenesis.
Closed-Loop Future Prediction of Continuous Ankle Kinematics and Kinetics Using Residual Muscle Signals of Transtibial Amputees
Authors: Zabre-Gonzalez Erika V. , Silver-Thorn Barbara , Current Thomas , Voglewede Philip A. , Koehler-McNicholas Sara R. , Beardsley Scott A. 
Published: November 2022

Abstract

Background Despite performance improvements in active lower limb prostheses, there remains a need for control techniques that incorporate direct user intent (e.g., myoelectric control) to limit the physical and cognitive demands and provide continuous, natural gait across terrains. Methods The ability of a nonlinear autoregressive neural network with exogenous inputs (NARX) to continuously predict future (up to 142 ms ahead of time) ankle angle and moment of three transtibial amputees was examined across ambulation conditions (level overground walking, stair ascent, and stair descent) and terrain transitions. Within-socket residual EMG of the prosthetic side, in conjunction with sound-limb shank velocity, were used as inputs to the single-network NARX model to predict sound-limb ankle dynamics. By overlaying the ankle dynamics of the sound limb onto the prosthesis, the approach is a step forward to establish a more normal gait by creating symmetric gait patterns. The NARX model was trained and tested as a closed-loop network (model predictions fed back as recurrent inputs, rather than error-free targets) to ensure accuracy and stability when implemented in a feedback control system. Results Ankle angle and moment predictions of amputee models were accurate across ambulation conditions and terrain transitions with root-mean-square errors (RMSE) less than 3.7 degrees and 0.22 Nm/kg, respectively, and cross-correlations (R2) greater than 0.89 and 0.93, respectively, for predictions 58 ms ahead of time. The closed-loop NARX model had similar performance when characterizing normal ranges of ankle dynamics across able-bodied participants (n = 6;RMSEθ< 2.7°,R2θ> 0.95,RMSEM< 0.11 Nm/kg,R2M> 0.98 for predictions 58 ms ahead of time). Model performance was stable across a range of different EMG profiles, leveraging both EMG and shank velocity inputs for the prediction of ankle dynamics across ambulation conditions. Conclusions The use of natural, yet altered in amputees, muscle activity with information about limb state, coupled with the closed-loop predictive design, could provide intuitive user-driven and robust control by counteracting delays and proactively modifying gait in response to observed changes in terrain. The model takes an important step toward continuous real-time feedback control of active ankle-foot prostheses and robotic devices.
Constructing NaYF4: Yb, Tm@NH2-MIL-125(Ti) with up-conversion photoluminescence and its enhanced full-spectrum photocatalytic performance
Authors: Lou Yang , Wu Siqi , Wang Guanlong , Dong Xiaoli , Zhang Xiufang 
Published: November 2022

Abstract
The low utilization of solar energy due to the narrow response spectra limits the performance of current photocatalysts. Utilizing up-conversion photoluminescence is one of the effective methods to enhance photocatalytic ability. A new photocatalyst, NaYF4: Yb, Tm nanoparticles (NYT) embedded in NH2-MIL-125(Ti) (NYT@NH2-MIL-125(Ti)), was constructed aiming to efficiently degrade pollutant under full-spectrum illumination. The characterization certified that NYT had been successfully embedded in NH2-MIL-125(Ti). The photocatalytic activity of NYT@NH2-MIL-125(Ti) was tested by degrading rhodamine B (RhB). The NYT@NH2-MIL-125(Ti) showed significantly enhanced photocatalytic activity compared with NH2-MIL-125(Ti), whose degradation kinetic constant of RhB was 3.73 times that of NH2-MIL-125(Ti). The enhanced photocatalytic performance should be attributed to the expanded response light spectra. Under illumination, NYT absorbs near infrared (NIR) light and emits visible light, which stimulates NH2-MIL-125(Ti) to produce photo-generated electrons-holes. Free radical trapping experiments certified that holes(h+) plays a major role in the photocatalytic process. This work deepens the understanding of construction of high-efficiency photocatalyst with a broad spectrum response, and promotes the application of photocatalysis in water pollution control.
Extracting the Invisible: Mesial Temporal Source Detection in Simultaneous EEG and SEEG Recordings
Authors: Ternisien Eric , Cecchin Thierry , Colnat-Coulbois Sophie , Maillard Louis Georges , Koessler Laurent 
Published: November 2022

Abstract
Epileptic source detection relies mainly on visual expertise of scalp EEG signals, but it is recognised that epileptic discharges can escape to this expertise due to a deep localization of the brain sources that induce a very low, even negative, signal to noise ratio. In this methodological study, we aimed at automatically extract deep mesial temporal sources that were invisible in scalp EEG signals using blind source separation (BSS) methods (infomax ICA, extended infomax ICA, and JADE) combined with a statistical measure (kurtosis). We estimated the effect of different methodological and physiological parameters that could alter or improve the automatic extraction. Using nine well-defined mesial epileptic networks (1,949 spikes) obtained from seven patients and simultaneous EEG-SEEG recordings, the first independent component extracted from the scalp EEG signals was validated in mean from 46–80% according to the different parameters. The three BSS methods equally performed (no significant difference) and no influence of the number of scalp electrodes used was found. At the opposite, the number and amplitude of spikes included in the averaging before the extraction modified the performance. Anyway, despite their invisibility in scalp EEG signals, this study demonstrates that deep source extraction is feasible under certain conditions and with the use of common signal analysis toolboxes. This finding confirms the crucial need to continue the signal analysis of scalp EEG recordings for extracting new electrophysiological biomarkers.
Do nomadic lactobacilli fit as potential vaginal probiotics? The answer lies in a successful selective multi-step and scoring approach
Authors: Cappello Claudia , Acin-Albiac Marta , Pinto Daniela , Polo Andrea , Filannino Pasquale , Rinaldi Fabio , Gobbetti Marco , Cagno Raffaella Di 
Published: November 2022

Abstract
Background
The goal of this study was to create a multi-strain probiotic gel that would foster a lactobacilli-dominated vaginal microbiota in pregnant women and ensure appropriate eubiosis for the newborn. Nomadic lactobacilli (95 strains), mostly isolated from food sources, were preliminarily screened for functional traits before being characterized for their capability to inhibit the two vaginal pathogens Streptococcus agalactiae and Candida albicans, which may lead to adverse pregnancy-related outcomes. Eight best-performing strains were chosen and furtherly investigated for their ability to produce biofilm. Lastly, the two selected potential probiotic candidates were analyzed in vitro for their ability to reduce the inflammation caused by C. albicans infection on the reconstituted human vaginal epithelium (HVE).
Results
Lactiplantibacillus plantarum produced both isomers of lactic acid, while Lacticaseibacillus paracasei produced only L-isomer. The production of hydrogen peroxide was strain-dependent, with the highest concentrations found within Lact. paracasei strains. The auto-aggregation capacity and hydrophobicity traits were species-independent. S. agalactiae 88II3 was strongly inhibited both at pH 7.0 and 4.0, whereas the inhibition of C. albicans UNIBZ54 was less frequent. Overall, L. plantarum strains had the highest pathogen inhibition and functional scoring. L. plantarum C5 and POM1, which were selected as potential probiotic candidates also based on their ability to form biofilms, were able to counteract the inflammation process caused by C. albicans infection in the HVE model.
Conclusions
Our multi-step and cumulative scoring-based approach was proven successful in mining and highlighting the probiotic potential of two nomadic lactobacilli strains (L. plantarum C5 and POM1), being applicable to preserve and improve human vaginal health.
Research on the evolution of the deviatoric stress and control of a gas extraction roadway under mining influence
Authors: Shan Renliang , Wei Yonghui , Wang Chunhe , Li Zhaolong , Zhao Yan , Tong Xiao , Xiao Shengchao 
Published: November 2022

Abstract
Aiming at the considerable deformation of the surrounding rock and the difficulty of supporting a roadway affected by the mining of close-distance coal seams, this paper takes the 10607 gas extraction roadway of the Malan Coal Mine as the subject of the study, an analysis of the stress distribution of roadway surrounding rock is conducted using a circular hole problem involving plane strains. Using a mechanical model of the roadway, the formula for the second invariant J2 of the deviatoric stress is theoretically derived. The deviatoric stress distribution characteristics of the coal pillar floor and the longwall panel floor are analyzed by using the simulation calculation software, and the deviatoric stress evolution of the surrounding rock of the lower gas extraction roadway during the mining of the upper coal seam longwall panel in the close-distance coal seams is studied. According to the evolution of the deviatoric stress of the surrounding rock of the gas extraction roadway during the mining, a CFST composite support reinforcement scheme is proposed and applied to the 10607 gas extraction roadway of the Malan Coal Mine.
A bibliometric study of emerging trends in the equity options segment
Authors: Singh Tejinder , Bajwa Rubeena 
Published: November 2022

AbstractIndex options and stock options are part of equity options segment in particular and the equity derivatives segment in general. This study examines the evolution of index options and stock options as modern financial instruments along with open interest. 759 studies were reviewed from 1982 to 2022. The equity options market informational content is particularly helpful in forecasting future prices. As a result, it is a favourite of traders and short-term investors, but this subject needs more research. The study used a bibliometric and network analysis tool to identify the most cited studies, leading journals, and authors. The thematic structure of research on equity options and open interest has been inferred using the bibliometric analyses in this review paper. With the help of the Scopus database, the results have been summarized, covering the broad topics of volatility, options and option prices, stochastic models, financial markets and stock markets, hedging, Granger causality, price determination, model test, information asymmetry, equity and the VIX index. During this review study, researchers found that day traders and short-term investors can use the information in open interest, index options, and stock options to predict future prices.JEL ClassificationG1 · G3 · G12 · G14
A Prognostic and Immunological Analysis of 7B-containing Kelch structural domain（KLHDC7B）in Pan- Cancer: A Potential Target for Immunotherapy and Survival
Authors: Ji Xunhui , Ding Jiatong , Liu Lanqi , Chen De-Zhi , Luo Nan , Guo Fei , Yu Xiao-Ting 
Published: November 2022

Abstract
Purpose
KLHDC7B is a member of Kelch family, with a Kelch domain in the C-terminal half, which plays a role in various cellular events, such as cytoskeletal arrangement, protein degradation, gene expression. Despite increasing evidence supporting KLHDC7B's vital role in tumorigenesis, a systematic analysis of KLHDC7B in cancers is lacking. Therefore, we intended to investigate the prognostic value for KLHDC7B across 33 cancer types and explore its potential immunological function.
Methods
GEO and TCGA databases were used to explore the role of KLHDC7B in 33 cancers. TIMER2, GEPIA2 and Kaplan–Meier plotter were utilized to explore the KLHDC7B expression level and prognostic value in different cancers. The pan cancer genetic variation and DNA methylation of KLHDC7B were analyzed by cBioPortal and MEXPRESS.TIMER2 was employed to investigate the correlation between KLHDC7B expression and immune infiltration. The relationship of KLHDC7B expression with TMB (tumor mutational burden) and MSI (microsatellite instability) were evaluated using Spearman correlation analysis. Finally, by GO and KEGG enrichment analysis, the underlying mechanisms of KLHDC7B in tumor pathophysiology were further investigated.
Results
KLHDC7B expression level was related to pathological stage, MSI, TMB, and immune cell infiltration in most cancers. Additionally, survival analysis showed that the expression of KLHDC7B was connected with overall survival (OS) in 3 cancers and disease-free survival (DFS) in five cancers. Furthermore, the enrichment analysis revealed that the KLHDC7B collecting genes and binding proteins are related to the function of proteins and immune response of cells.
Conclusion
KLHDC7B demonstrate strong clinical utility as markers of prognostic and immune response in pan-cancer.
Do remittances increase tax revenues in developing countries? Evidence from the threshold regression models
Authors: BANGAKE Chrysost , AVOM Désiré , NDOYA Hermann , ADOUMA Prince 
Published: November 2022

Abstract
This paper provides original econometric evidence on the effect of remittances on tax revenue in developing countries. In applying the system generalized methods of moments (SGMM) and the panel threshold regression method to a sample of 83 developing countries over the period 1990–2019, we find two major results. First, remittances positively and significantly affect tax revenue in developing countries. Second, as far as the nonlinear relationship is concerned, we find two extreme regimes with a smooth shift characterizing the remittances-tax revenue nexus, with respect to conditional variables; remittance effects are positive and significant under the first regime and negative and significant under the second. Furthermore, our findings show that the nonlinear relationship between remittances and tax revenue depends on the levels of informal economy, law and order, corruption and trade openness.
Gendered late working life trajectories, family history and welfare regimes: Evidence from SHARELIFE
Authors: Schmitz Wiebke , Naegele Laura , Frerichs Frerich , Ellwardt Lea 
Published: November 2022

Abstract
Background
Earlier employment choices based on family events in earlier life have an impact up until late working life. Especially in welfare regimes that encourage the breadwinner-caretaker division. We investigate types of late employment patterns and how these are associated with earlier family events. Third, we test whether the association between early family history and late working life varies across five welfare regimes.
Methods
We use retrospective life history data from SHARELIFE. Our sample consists of 10,944 women and 10,662 men aged 65 years and older. Late working life trajectories are analyzed using gender-separate sequence analyses, which are summarized into eight groups applying cluster analyses. Using average marginal and interaction effects we explain how the association between types of late working life, coresidential partnership history and parenthood history differs by welfare states.
Results
Women’s late employment is either shaped by unpaid care or paid (full- or part-time) work but not both, whereas men’s late working life is mainly shaped by full-time work. Family history in earlier life is linked to unpaid care and part-time work – this association is strongest in liberal and southern welfare regimes. However, among men earlier family events are linked to full-time work.
Discussion
Policymakers need gender-specific strategies to integrate workers into late working life. The implementing of new policies should aim to prevent these social inequalities in early life, as employment decisions caused by family history in earlier life stages – especially for women – tend to cumulate over the life course.
Whole-Ecosystem Climate Manipulation Effects on Total Mercury within a Boreal Peatland
Authors: Pierce Caroline , Psarska Sona , Stewart Brandy D. , Oleheiser Keith , Griffiths Natalie A. , Gutknecht Jessica L. M. , Kolka Randall K. , Sebestyen Stephen D. , Nater Edward A. , Toner Brandy M. 
Published: November 2022

Abstract
Mercury is a ubiquitous pollutant that accumulates in peatlands, an ecosystem highly sensitive to climate change. We examined the effects of increasing temperature and elevated atmospheric carbon dioxide (CO2) on the concentration of total mercury (THg) in peatland soil and porewater. This research was performed at the Spruce and Peatland Responses Under Changing Environments (SPRUCE) experiment, an ecosystem-scale manipulation in an ombrotrophic bog in northern Minnesota, USA, which includes five temperature levels (above- and below-ground warming), with ambient or enhanced CO2 concentration. The effect of temperature on THgporewater concentration was dependent on depth but overall, increasing temperature led to increased THgporewater concentrations. The ratio of THgpeat to THgporewater decreased, indicating that THg moved from the peat into porewater under warmer conditions. Increased temperature resulted in decreased water table height, and as the water table dropped, increased THgporewater concentrations were observed, as well as decreased THgpeat concentration. The effect of elevated CO2 on THg concentrations in peat and porewater was less clear but in the top portion of the depth profile (0 cm to -40 cm), a negative correlation between elevated CO2 and THgpeat and a positive correlation between elevated CO2 and THgporewater concentration was observed. Our findings indicate with projected climate change, we may see enhanced concentrations of mercury in peatland porewaters that are available for export to surface waters, with potential implications for bioaccumulation in downstream aquatic communities.
Cutting performance and surface quality of Ti-6Al-4V by longitudinal ultrasonic vibration-assisted high-speed dry milling with coated carbide tools
Authors: Zhang Jin , Ling Li , Luo Daixin , Deng Chenjie , Huang Xuefeng , Tao Guibao , Cao Huajun 
Published: November 2022

Abstract
Longitudinal ultrasonic vibration-assisted high-speed dry milling (LUVAHSDM) is performed to improve cutting performance and surface quality of Ti-6Al-4V (TC4). Multifaceted comparisons are presented in milling results of AlCrN, AlCrSiN, AlTiN and AlTiSiN-coated tools in terms of milling force, milling temperature, tool wear, 3D surface roughness and residual stress. The results show that maximum milling force in both the feed and longitudinal directions first decreased and then increased with increasing Al element content as well as single edge and average flank wear. Therefore, the surface roughness of TC4 becomes more uniform when using AlTiN-coated tools, the residual stress is greatly reduced to 98.57 MPa. Combining milling force, milling temperature, tool wear, 3D surface roughness and residual stress data, it is found that AITiN-coated tools achieve both excellent cutting performance and surface quality. The excellent machining performance demonstrates the feasibility and effectiveness of applying LUVAHSDM methods.
Pharmaceutical money to Japanese board-certified dermatologists: A four-year retrospective analysis of personal payments from pharmaceutical companies between 2016 and 2019
Authors: Murayama Anju , Saito Hiroaki , Kugo Hinari , Yamashita Erika , Tanimoto Tetsuya , Ozaki Akihiko 
Published: November 2022

Abstract
There are prevalent financial relationships between dermatologists and pharmaceutical companies in Japan. However little was known about the extent of whole picture of the personal payments made to dermatologists by pharmaceutical companies. This study aimed to examine the personal payments to the board-certified dermatologists by the Japanese Dermatological Association from the pharmaceutical companies between 2016 and 2019. Using the publicly disclosed payments data by the pharmaceutical companies between 2016 and 2019, we evaluated the magnitude, prevalence, and trends in the personal payments made to all board-certified dermatologists for the lecturing, writing, and consulting compensations. The payments were descriptively analyzed overall and by dermatologist demographics. Additionally, the payment trends were assessed by generalized estimating equation models. Of 6883 active board-certified dermatologists, 3121 (45.3%) received a total of $33,223,806 personal payments between 2016 and 2019. The median per-physician payments and number of payments (interquartile range) were $1,737 ($613–$5,287) and 4.0 (2.0–10.0) over the four years, respectively. Only top 1%, 5%, 10% of dermatologists received 41.7% (95% confidence interval [CI]: 38.2–45.1%), 76.9% (95% CI: 74.7–79.1%), and 87.6% (95% CI: 86.2–88.9%) of overall payments. The number of dermatologists receiving payments and per-dermatologist payments increased by 4.3% (95% CI: 3.1%‒5.5%, p < 0.001) and 16.4% (95% CI: 13.5%‒19.4%, p < 0.001) each year. The board-certification in dermatology-oncology, in cosmetic dermatology, and male sex were significantly associated with higher personal payments with relative monetary values of 2.29 (95% CI: 1.65–3.19, p < 0.001), 3.16 (95% CI: 1.89–5.26, p < 0.001), and 5.38 (95% CI: 4.12–7.04, p < 0.001). Less than half of Japanese board-certified dermatologists received lower personal payments from the pharmaceutical companies than those to other specialists. However, these personal payments were increasingly more prevalent and greater over the four years.