bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Group Work to Teach Literature in an Online Classroom Environment
Authors: Zubeidah Zachariah Tirzah , Izahar Mustafa , Elias Zalilah , Nazir Md Zabit Mohd 
Published: March 2022

This paper aims to look at TESL students’ views of the utilisation of group work to teach literature online. A questionnaire was administered to a sample of 64 TESL trainee teachers from Universiti Selangor who were enrolled in an online Literature class in April 2021. There were three sections in the questionnaire which had to be answered using a five-point Likert scale. The questionnaires were distributed through the WhatsApp application to the students. The data were analysed using frequency counts and percentage. The study findings showed that most of the students had positive views about the use of group work for learning literature. The students were also satisfied with their peer collaboration and teacher collaboration throughout the group activities.
Keywords: group work, literature, online learning, TESL
Online Learning: Yea or Nay?
Authors: Febrie Novitasari Nine 
Published: March 2022

The Covid-19 pandemic has changed the education system in Indonesia from conventional offline classes to online classes. This sudden change has influenced the process of learning both positively and negatively. To some extent, online learning is considered advantageous; however, for prolonged use, it has some evident drawbacks. The pros and cons of online learning are also experienced by the students of English Literature at UNARS. Accordingly, a survey was conducted among 62 students to see how they perceived online learning. This research also examined how online learning has affected the students’ study of English. The results showed that even though online learning was considered to not be as pleasant as offline learning, online learning was rated as somewhat enjoyable by 45.2% of the students.
Keywords: online learning, students’ point of view, survey
Senior and Junior EFL Teachers’ Pedagogical Knowledge: Levels and Areas of Mastery and Non-mastery
Authors: . Suharyadi , H. Sulistyo Gunadi 
Published: March 2022

This study is intended to investigate the levels and areas of mastery and non-mastery of senior and junior EFL teachers’ pedagogical knowledge (PK) in the Indonesian context. Involving 60 participants consisting of 24 senior EFL teachers of junior high schools and 36 junior EFL teachers who joined PPG, this study made use of a set of a questionnaire comprising 25 items. The data were analyzed quantitatively by employing Descriptive Statistics and T-Test. The data analysis shows that there is no statistically significant difference/level between senior and junior EFL teachers’ pedagogical knowledge. Although their scores are not significantly different, senior EFL teachers know not better than those of junior EFL teachers. There are more aspects of PK they do not know. Senior EFL teachers are fully weak in dealing with the teaching profession, ELT theory, and research, while junior EFL teachers are fully weak in the teaching profession and ELT theory. Based on these findings, EFL teachers are suggested to join more workshops, training, and seminar to improve their pedagogical knowledge. Reading and writing activities are also useful to strengthen their knowledge and understanding of PK.
Keywords: senior and junior, EFL teachers, pedagogical knowledge
Enhancing Primary School Teachers’ Creative Writing Skills through Reflective Training
Authors: Rachmajanti Sri , Ariani Nova , Karmina Sari , Heki Sujiatmoko Ahmad 
Published: March 2022

In the domain of education, great teachers are those who facilitate students’ learning effectively in an inspiring learning environment. Therefore, they should continuously develop and empower their professional and pedagogical competencies. In fact, there emerge abundant ways to empower themselves, and one of which is through the so-called ‘reflective training’. As empirical evidence, English teachers in specific primary schools have not reached the expected level of CEFR criteria for creative writing (B1 at the minimum). For this reason, this study adopted action research via the implementation of reflective training to enhance the subjects’ creative writing skills in one cycle incorporating planning, taking action(s), observing, and reflecting. Three instruments were employed, i.e., writing tasks, observation sheets, and questionnaires. Creative writing rubrics were taken from CEFR and Mozaffari to evaluate teachers’ writing. The training made the teachers engaged in producing a piece of creating writing as output and allow them to reflect and improve it with the elements of creative writing aspects namely image, characterization, voice, and story. Teachers have successfully completed their writings with theories and skills in their writing products to reach the B2 CEFR level in creative writing.
Keywords: primary school teachers, creative writing skills, reflective training, CEFR
Representing Invisible Politics of Shakespearian Plays in Orson Welles’ Chimes at Midnight
Authors: Wahyu Widodo Herditya 
Published: March 2022

The full construction of the main character Falstaff, as a figure in the Shakespearean movie adaptation Chimes at Midnight, exists through the intertextual relationship between the film and the original Shakespearian plays. In this study, I argue that much of this intertextual material is non-existent in the film, but relies in its availability the audience’s own mind watching the film. By merely hinting at an incomplete material, the film recreates the entire feeling of a seemingly complete Shakespearean material with its original political preoccupations. This illusion of the complete text is shown in the isolated battle scenes that do not contribute much to the development of Falstaff, and the impotent military imageries in the film. However, the scenes where Falstaff’s foils are presented: the Earl of Worcester’s lies and the dying lamentations of Hotspur, are more evidently meant to give the impression that the film significantly adapt the original plays’ political motives that the film do not really concern itself with.
Keywords: Chimes at Midnight, Orson Wells, Intertextuality, Shakespeare, Falstaff, 1 Henry IV, 2 Henry IV
EFL Students’ Use of the Verb ‘See’: A Conceptual Metaphor Analysis
Authors: Zubaidi Nanang , Nasihah Durotun 
Published: March 2022

This study investigated Indonesian EFL university students’ use of conceptual metaphor with the English perception verb ‘see’. The idea of a conceptual metaphor refers to how people understand someone's idea represented by linguistics elements. The use of perception verbs in everyday life combined with other words that do not correlate with the five senses can inform readers of the state of language use in certain contexts. The methods employed in this research were descriptive and qualitative. The data were collected from the essays of Indonesian EFL university students (n = 27 students and 390 essays) and were processed and analyzed using AntFileConverter and AntConc concordance software. The researchers classified the perception verb ‘see’ based on its form, structure and meaning, and analyzed the conceptual metaphors. Five concepts of metaphors were found for the English perception verb ‘see’, including impression, fantasy, understanding, assumption, and prediction.
Keywords: conceptual metaphors, source domain, target domain, English perception verb, verb ‘see’
A university-school partnership in Lesson Study Implementation: Effects on Students' Grammatical and Speaking Skills and Stakeholders' Perceptions
Authors: Suryati Nunung , Hayati Nur , Ibnu Hajar Nasib , . Toekiningsih , Herqutanto Totok 
Published: March 2022

This study investigates the effects of the Lesson Study approach on Indonesian junior high school students' grammar and speaking skills and the stakeholders' perceptions of the approach's usefulness. It involved 90 students, three teachers of Junior High School and two university lecturers in Indonesia. The study employed a quasi-experimental study and a survey. In the quasi-experimental study, the students were assigned into two groups: experimental and control. The experimental groups were exposed to the instruction guided by the Lesson Study approach, while the control group was taught using conventional approach. The treatment was conducted in eight sessions, including the pre-test and post-test. The effect of the treatment on the students’ grammar knowledge and speaking skills were measured by a quantitative analysis of their scores in the pre-test and post-test. The survey was conducted to examine the perceptions of the practice of Lesson Study as voiced by the students, teachers and lecturers involved. To obtain the data, student questionnaire and interview, and teacher self-reflection were used. The results of the study revealed that the Lesson study practice effectively enhanced the students' grammar and speaking skills. Additionally, the students, teachers, and teacher educators perceived the Lesson Study approach was valuable, although the teachers faced some challenges in practicing the Lesson study approach.
Keywords: lesson study impact; stakeholders' perceptions, EFL context, Indonesia
MTHFD2 Expression Profile and Its Prognostic Importance in Invasive Breast Carcinoma
Authors: Arslan Remzi , Ceylan Onur 
Published: March 2022

Background: Breast cancer is the most common cancer among women. Therefore, it is very important to determine prognostic parameters and biomarkers related to these parameters. Recent studies have shown that folate metabolism is effective on cell division and invasiveness. One of the most important regulators of folate metabolism is the methylene tetrahydrofolate dehydrogenase enzyme (MTHFD2).
Method: This study, immunohistochemical staining with MTHFD2 was performed in 194 cases diagnosed with invasive breast carcinoma. The relationship between the immunohistochemical expression of MTHFD2 in normal ductal areas and invasive tumoral areas of these cases and some clinicopathological parameters was investigated.
Results: While no expression was observed in non-tumor areas with MTHFD2, varying degrees of expression were observed in all tumor areas (p<0.0001). Significant correlations were also observed between important clinicopathological and prognostic parameters such as MTHFD2 nuclear grade, hormonal receptor, Ki67 and etc. (all p<0.05).
Conclusion: High MTHFD2 expression in breast carcinomas with invasive and poor prognostic values ​​was determined to be very significant. Therefore, it can be predicted that detecting and lowering MTHFD2 levels in these cases may prevent tumor development, invasion and metastasis. We think that more studies on the subject are needed, including the development of chemotherapeutics targeting MTHFD2.
Non-Pharmacological Balance Therapy on Diabetic Peripheral Neuropathy Patients with Balance Disorders
Authors: Sibarani Jeremy Nicolas , Wigati Kristanti Wanito , Subadi Imam 
Published: March 2022

ABSTRACTBackground: Patients with diabetic peripheral neuropathy (DPN) suffers from propioceptive ability and mobility disturbance which can potentially affects balance. There are various balance therapy options for DPN patients. The purpose of this study was to determine the effectiveness of various non-pharmacological therapies (surgery, traditional medicine, exercise and assistive devices) in DPN patients with balance disorders.Aim(s): To determine the effectiveness of non-pharmacological balance therapy in people with diabetic peripheral neuropathyMaterial and methods: A systematic review was conducted using randomized controlled trial study articles found using PICO characteristics in ScienceDirect and PubMed in the last 10 years. All articles were selected based on PRISMA and descriptive analysis was carried out on the selected articles.Result: Significant balance improvement found in traditional Thai massage, physical exercise therapy, assistive device therapy with whole-body vibration, and assistive device therapy with electrical stimulation. Surgical therapy with unilateral nerve decompression did not provide a significant measurable balance improvement.Conclusions: Physical exercise therapy, traditional Thai foot massage, WBV and electrical stimulation therapy (with the exception of TENS on the knee) significantly improve balance. Meanwhile, unilateral nerve decompression surgical therapy did not improve the balance significantly.
The Potential of Rosuvastatin in Stabilizing Lipid Profile and Improving Clinical Outcomes in Covid-19 Patients with Coronary Heart Disease
Authors: Suciangto William , Rasyid Haerani , Nasrum Nada Indira Ramadhani , Rahmani Muhammad Zaki 
Published: March 2022

Introduction : The novel coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global challenge since December 2019 cause by its severe symptoms and high mortality rate. Some comorbidities are associated with clinical outcomes in COVID-19 patients, one of them is cardiovascular disease, including coronary heart disease (CHD). Statins are popularly used as the lipid controller in CHD patients. Not only controlling the lipid profile, statins also can reduce the inflammation process in COVID-19 patients. This review aims to determine the activity of statins and its potential to improve the clinical manifestation of COVID-19 patients with CHD. Methods : The method used in this paper is to examine and review the literature journal that has been published last 10 years. Results : Recent studies have shown that statins capable to control the lipid, also lowering the LDL cholesterol and increasing the HDL cholesterol. And other trials have shown that statin also have ability to reduce the inflammation and inhibit further cell damage by binding mpro, a protease produced by SARS-COV2. Conclusions: Based on those studies, we conclude that statins have the potential effect as adjuvant therapy for clinical improvement in COVID-19 patients with CHD.
A Prospective, Non-Randomized, Consecutive Series, Multicentre, Observational Study to Evaluate The Clinical Outcome of Ceramic-On-Ceramic Hip Resurfacing Arthroplasty Using The Ceramic, Non-Porous, Non-Cemented H1 Hip Resurfacing Arthroplasty
Authors: Al-Laith Mariam , Clarke Susannah , Halewood Camilla , Wozencroft Robert , Guest Brogan , Straeten Catherine Van Der , Fiorentino Francesca , Cobb Justin 
Published: March 2022

Abstract
Background: Advantages of hip resurfacing arthroplasty over total hip arthroplasty include the preservation of the thigh bone, reduction in the risk of dislocation due to the large size of the ball, revision surgery being easier, and higher activity level in younger participants. However, metal-on-metal hip resurfacings has been shown to cause higher metal ion levels and some participants reported progressive pain leading to early revision. By exchanging the metal material of the bearing with BIOLOX®delta ceramic, the main cause of early revision is removed. The H1 Implant is innovative both in its anatomical shape and in its materials as there is currently no all-ceramic, completely cementless hip resurfacing implant in clinical use. Methods: This is a multicentre, prospective, non-randomized, observational study to evaluate the clinical outcome of the H1 System, which consists of the H1 Implant and the H1 Instruments. The intended application of the H1 Implant is to replace the diseased areas of the articular surface and restore joint function. The aim is to recruit 250 participants. Adult participants up to the age of 70 years will be recruited and followed-up for 10 years from the date of surgery. All operative complications, both intraoperative and postoperative through discharge will be collected. Any complication, whether device-related, surgery related or otherwise, will be collected and reported where applicable. The assessment of the safety and performance characteristics as well as establish the superiority of the ceramic-on-ceramic bearing couple of the H1 Implant will be evaluated and compared to metal-on-metal hip resurfacings in the literature.Discussion: This study protocol describes the H1 Clinical Investigation. The protocol was designed by clinicians, experienced trialists and patients, in order to test the safety and performance of The H1 System. Trial registration: ISRCTN registry with study ID ISRCTN91554748
CT-Navigated Percutaneous Posterior Positioning of Pedicle Screws in The Cervical Spine
Authors: Keil Holger , Kreinest Michael , Grützner Paul Alfred , Vetter Sven Yves 
Published: March 2022

Abstract
Background To evaluate reliability, practicability and precision of a novel intraoperative computed tomography(iCT)-based (Airo mobile CT scanner, Brainlab, Munich, Germany) navigated procedure to minimally-invasive positioning of cervical pedicle screws.Methods Ten consecutive patients that suffered from a cervical traumatic instability needing posterior fixation were included in this retrospective analysis. Posterior pedicle screws were positioned iCT-navigated percutaneously. After positioning of the screws, a control scan was performed to assess screw placement and correction if needed. All CT scans were randomly evaluated by two investigators with experience in skeletal CT diagnostics. In the iCT scans, positioning of the screws regarding affection of the medial pedicle cortex as well as the neuroforamina were measured. Additionally, image quality was evaluated with a subjective Likert-Scale (0-5) and a semi-objective Assessability score (0-4).Results 44 screws were placed in an average duration of surgery of 139min [83-209]. The average subjective image quality was 3.9 [2-5], the average assessability score was 3.7 [2-4]. 27 screws (61%) were positioned exactly centered in the pedicle. 4 screws perforated the medial wall by more than 2mm [2.8-2.9]. 9 screws were positioned laterally by more than 2mm [2.5-4.9]. No postoperative neurological deficits were observed.Conclusion iCT-navigated percutaneous placement of pedicle screws is a rather safe and reliable method for posterior fixation of the cervical spine that allows fixation of traumatic cervical instabilities with minimal additional trauma. Even in shallow anatomic structures, visualization of instruments and implants allows for minimally invasive surgery.
The Biological Behavior of High-Grade Glioma in H3K27M Mutant Circumscribed Midline Gliomas
Authors: Li Zhi , Li Hainan , Tan Jieyun , Lai Mingyao , Chen Wendan , Liu Minting , Zhou Zhaoming , Deng Dabiao , Cheng Baijie , Fan Chongzuo , Cai Linbo 
Published: March 2022

Abstract
Purpose: Due to the prognosis of circumscribed midline gliomas（CMGs）with H3K27M mutation is still unclear. This study explored the prognostic stratification of （CMGs） with H3K27M mutation.Methods: One hundred and sixty midline gliomas（MGs）were identified over 10 years. Immunohistochemistry was done for H3K27M, ATRX, IDH1, and P53, and Sanger sequencing performed for IDH and H3 genes. The clinicopathological characteristics were reviewed and survival analysis performed.Results: 1. For H3K27M mutant MGs, there was no difference in prognosis between diffuse midline gliomas (DMGs) and CMGs (p = 0.211), also between the CNS WHO grades.2. The prognosis of H3K27M mutant CMGs of CNS WHO grade 1 was worse than that of H3K27M wild-type CMGs (p = 0.0024), even worse than of DMGs without H3K27M mutation of CNS WHO grade 2(p = 0.0066).Conclusions: The weight value of H3K27M affecting prognosis is affected by location and age. CMGs with H3K27M mutation have biological behavior similar to high-grade gliomas. It is recommended that Treatment management was referenced to high-grade glioma for CMGs with H3K27 mutation.
Recording and Modeling the Seasonal Growth of Suaeda Heteroptera at Liao River Estuary, China, Based on the Wetland Image Monitoring System (WIMS)
Authors: Wang Yicong , Liang Xianmeng , Yu Yang , Yu Changbin , Yang Min , Wu Guojun 
Published: March 2022

Abstract
Wetland ecology monitoring is an important technical guarantee for the protection and restoration of fragile wetland environments. In view of the degradation of the functional vegetation Suaeda heteroptera ( S. heteroptera ) in the Liao River Estuary wetland, an online monitoring method named the Wetland Image Monitoring System (WIMS) was established to obtain real-time, continuous, high spatial and temporal resolution data about the area and height of S. heteroptera . Based on the monitoring data, we confirmed the best model to describe the change process of the area and height for S. heteroptera . The results showed that the growth of S. heteroptera could be divided into three stages: in April and May, the area and height of the S. heteroptera increased rapidly; from June to September, the growth rate slowed down; after October, the area and height of S. heteroptera gradually stabilized. The modeling results showed that the Bertalanffy model had the best simulation performance on the change of the area. While for the height simulation, the segment model composed of the linear and Gompertz models could effectively reduce the simulation error and improve the fit accuracy compared with the single model. In addition, the WIMS has the potential to capture other important ecological factors in small regions, such as benthic animals, birds, waterlogging condition, etc. This observing method can provide high-resolution and abundant data for further exploration of the degradation of typical ecosystems under climate change and human activities.
Efficacy and safety of substitute vincristine with vindesine in R-CHOP- like regimen in the treatment of newly diagnosed DLBCL, a real-world study
Authors: Sun Xiao-Hong , Wan Shun , Bai Xiao-Teng , Li Zi-Jian 
Published: March 2022

Abstract
Background The replacement of doxorubicin with other anthracyclines like epirubicin, pirarubicin, or liposomal adriamycin in the R-CHOP regime showed non-inferiority for DLBCL. Replacing vincristine with vindesine (R-CHVP) in R-CHOP has rarely been compared in efficacy and safety. This study aimed to figure out whether R-CHVP was non-inferior to R-CHOP in both efficacy and toxic effects.Methods This is a retrospective study performed at The First Hospital of Lanzhou University, including all consecutive adult patients aged over 18 years with newly diagnosed DLBCL who received therapy with R-CHOP or R-CHVP from March 2008 to September 2020. We compared the efficacy and safety of the R-CHVP regimen with vincristine and the R-CHOP regimen with vindesine.Results We identified 56 patients with DLBCL, including 18 patients in R-CHOP, 7 in R-CTOP, 12 in R-CEOP, 17 in R-CEVP, 11 in R-CTVP. Complete response was achieved in 12(66.7%), 4(57.1%), 5(41.7%), 7(41.2%) and 4(36.4%) patients respectively. The ORR of the five different schemes is 83.3%, 85.7%, 66.7%，64.07%，and 81.8%, respectively. The most common hematological adverse events during induction were anemia and neutropenia, and the most common non-hematological toxicity are gastrointestinal symptoms and neurotoxicity. The comparison of adverse events between R-CEOP and R-CEVP groups is as follows: the toxicity of hematological adverse events was not statistically significant; among non-hematological toxicity, the R-CEVP group was superior to the R-CEOP group in peripheral neuropathy (p=0.026). The 2-year progression-free survival were 75.5%, 54.6%, 53.2%, 62.7% and 42.4% in R-CHOP, R-CTOP, RCEOP, R-CEVP and R-CTVP group respectively.Conclusion The R-CHVP, in which vincristine was substituted by vindesine, was not inferior to the standard R-CHOP regimen and showed less neurotoxicity. Treatment regimens composed of different anthracyclines have similar therapeutic benefits and adverse events in addition to cardiotoxicity.