bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of Maastrichtian–Thanetian benthic foraminiferal species diversity, palaeooxygenation and palaeoproductivity in shallow waters of Western Desert, Egypt
Authors: Farouk Sherif , Jain Sreepat , Al-Kahtany Khaled , Ahmad Fayez , Abdeldaim Ahmed 
Published: November 2022

Abstract

Benthic foraminiferal analysis (315 samples, 16,271 specimens) of the shallow water (< 100 m) Maastrichtian–Thanetian rocks from the Dakhla Oasis (Western Desert, Egypt) were studied to infer the inter–relationships between species diversity, palaeooxygenation, palaeoproductivity, and palaeodepth and changes at the Cretaceous–Paleogene (K/Pg) boundary. Positive and significant correlations are noted between these proxies, suggesting a well–oxygenated oligotrophic environment. However, a brief interval (mid– lower Maastrichtian) of increased palaeoproductivity with reduced diversity and oxygenation (ventilation) is noted (a characteristic of mesotrophic–eutrophic settings) that coincides with very shallow waters during a Highstand System Tract (HST), and dominated by the dysoxic agglutinated species Ammobaculites khargaensis. The diversity index, Fisher’s α (< 5) and paleodepth proxy (foraminiferal wall structure types) also suggests a shallow neritic (largely littoral) depth for the entire study interval. At the bottom of the study section (Planktic Foraminiferal Zones CF8b-CF7), species diversity, palaeooxygenation, and palaeoproductivity are high. From the K/Pg boundary to the post K/Pg period, these variables are low and fluctuating with moderate species dominance. According to the available data, a 40% total extinction rate was seen after the K/Pg hiatus, with 38% of agglutinated species and 40% of calcareous extinct species. The period immediately following the K/Pg boundary is characterised by increased basinal ventilation and decreased palaeoproductivity, which are attributable to changes in sea level and concurrent regional subsidence. However, as stable as the community structure was (at or just after K/Pg), the changes in species composition (assemblage) were dramatic marked by a change from a pre–K/Pg agglutinated–dominated fauna (Haplophragmoides–Ammobaculites) to a post–K/Pg calcareous assemblage (Cibicodoides–Cibicides–Anomalinoides).
Viable Cryopreserved Human Bone Graft Exhibit Superior Osteogenic Properties In Mandibular Lateral Augmentation
Authors: Deluiz Daniel , Delcroix Gaëtan J.-R. , Fraga Samira R. G. , D’Ippolito Gianluca , Grau-Monge Cristina , Bonnin-Marquez Andrea , Reiner Teresita , Amadeu Thaís , Tinoco Eduardo M. B. , Schiller Paul Christian 
Published: November 2022

Abstract
Lack of bone volume to place dental implants is frequently a problem in the reconstruction of edentulous patients. Even though autografts are the gold standard for jaw regeneration, morbidity associated with the harvesting site stimulates the demand for other substitutes. The aim of this study is to characterize the incorporation and the osteogenic ability of a viable cryopreserved human bone graft (VC-HBG) in the mandibular augmentation in rats. Bone chips from fresh human vertebrae cadaveric donors were processed, cryoprotected and deep-frozen at -80oC maintaining its cell viability. A jaw augmentation model was used in 20 athymic nude rats allocated into 2 groups to either receive the VC-HBG or an acellular graft as control. The assessment of the grafts' incorporation was performed at 4 and 8 weeks by micro-CT, histomorphometry and immunohistochemistry. Bone volume gain was significantly higher for the VC-HBG group at both time points. At 4 weeks, the acellular group presented significantly higher mineral density, but at 8 weeks, the VC-HBG group showed significantly higher values than the acellular. There was no statistical difference between VC-HBG and acellular groups at 4-weeks for remaining graft particles, while at 8 weeks, the VC-HBG group showed significantly less graft remnants. Collagen I, osteopontin and tartrate-resistant acid phosphatase (TRAP) expression were significantly higher in the VC-HBG group at both time points, while osteocalcin expression was significantly higher in the VC-HBG group at 8-weeks compared to the acellular group. This experimental research demonstrated that the VC-HBG shows positive osteogenic properties, greater bone formation, higher rate of bone remodeling and a better overall incorporation in rats' mandibles compared to the acellular graft.
Microtomographic analysis of surgically-created bone defects in rats: manual versus predefined region-of-interest definition
Authors: Pitorro Tássio Edno Atanásio , Irie Milena Suemi , Bites Clara de Oliveira Barbosa , Spin-Neto Rubens , Soares Priscilla Barbosa Ferreira 
Published: November 2022

Abstract
Micro-computed tomography (micro CT) is a high-resolution radiographic modality that has been widely used in bone-tissue research. This study assessed whether there is an agreement between the manual and predefined region-of-interest (ROI) definition methods during the three-dimensional analysis of bone defects by micro-CT. Bone defects of 2.3 mm in diameter were created in the left tibiae of Wistar rats. After 14 days, the tibiae were collected and scanned. During the analysis by CtAnalyser® software, the ROI was defined in two different ways for each sample: manually (manualROI) and based on a predefined circular shape (circularROI). Data corresponding to bone volume fraction (BV/TV) and trabecular number (Tb.N) were analyzed. No difference was found between the groups for both BV/TV (p = 0.51) and Tb.N (p = 0.38), with an excellent correlation for BV/TV (r = 0.9). A non-significant correlation was observed for Tb.N (p = 0.1). The Bland–Altman analysis showed a low systematic error for BV/TV (1.2%) and Tb.N (0.2/mm). The manualROI was more time-consuming (512.8 ± 60.5 seconds) than the circularROI method (95.4 ± 9.4 seconds). Both methods provided similar results, therefore, predefined formats for ROI definition of regular lesions are indicated, considering their use is less time-consuming.
The effects of yoga interventions on sleep quality in adults people with depression and anxiety : a meta-analysis of randomized controlled trials.
Authors: Zhou Tian , He Li , Huang Tian 
Published: November 2022

Abstract
Background: Depression is a public health problem affecting older people and causes many health problems. We aim to estimate the effects of yoga interventions on depression, anxiety and sleep quality in adults using meta‐analysis.
Methods: Four digital databases were searched from the inception of databases to March 2022, including Web of Science, Cochrane Library, PubMed and Embase. The Cochrane Collaboration recommendations assessed the publication bias of the included studies. And all test models used a 95% confidence interval (CI).
Results: A total of 10 studies with 582 patients were included in this meta-analysis. The results demonstrated that the depression relief rate of experimental group was better than that of control group ( depression (SMD = -0.20, 95% CI (-0.63 - 0.23)， p<0.001), anxiety(SMD = -0.55, 95% CI (−1.29 to 0.19 )p<0.001). In addition, there was a significant improvement in sleep quality in the yoga group(SMD=-0.46,95% CI (-0.88,-0.05)p <0.001 ).
Conclusions: This review synthesized current evidence using yoga interventions to reduce negative emotion in adults, especially concerning targeting the applicability between different populations or intervention methods. In addition, yoga interventions are safe and convenient, which have great feasibility and potential to be used as an aspect of psychotherapy for clinical and nursing to improve well-being in adults.
Quality of life and anxiety in an underdeveloped city in IRAN during the COVID-19 pandemic: a cross-sectional study
Authors: Abdi Mohammadamin , Dahouei Arefeh Arabpour , Araghi Navid Mirzakhani 
Published: November 2022

Abstract
Purpose: Studies have widely explored the quality of life in wealthy communities during the COVID-19 pandemic; the present study selected the earthquake-prone and underdeveloped city, of Zarand (Iran) to examine the quality of life and anxiety.
Methods: 291 patients who were infected with COVID-19 in the last 14 days were included in the study. They were selected using systematic non-random sampling. The quality of life and anxiety of the participants were evaluated using the online WHO-Quality of Life-BREF and Beck Anxiety Inventory (BAI) respectively. The analysis was not limited to the significance and also included the effect size. Data were analyzed by SPSS software version 26 using Spearman's correlation, T-test, and Kruskal-Wallis.
Results: The quality of life scores were less than 50 out of 100 on average. 58% of patients reported moderate to severe anxiety and there was a negative correlation between all of the four physical(P value<0.001), psychological(P value<0.001), social(P value<0.007), and environmental(P value<0.001) domains of quality of life and anxiety, respectively. Education and quality of life were positively correlated in all domains except for the environmental domain. Participants' age ranged from 18 to 58 and the correlation between age and the physical and psychological domain was significant. No significant correlation was found between the quality of life, sex, and marital status.
Conclusions: The current study provides evidence of low Quality of life and high levels of anxiety in patients who experienced COVID-19. This implicates immediate considerations to be taken into account by policymakers and officials.
Learning curve and short-term clinical outcomes of a new seven-axis robot-assisted total knee arthroplasty system: A propensity-score-matched retrospective cohort study
Authors: Duan Xudong , Kong Ning , Cao Ruomu , Guan Huanshuai , Li Yiyang , Zhao Yiwei , Ali Umair , Wang Kunzheng , Yang Pei , Tian Run 
Published: November 2022

Abstract
Robot-assisted total knee arthroplasty (RA-TKA) requires a lot of training from surgeons to master it. The purpose of the present study was to determine the learning curve for a novel seven-axis RA-TKA system, and to explore whether it could provide superior short-term clinical and radiological outcomes compared with conventional surgery. In the present retrospective study, 180 patients from our hospital with primary unilateral TKA were included, from January 2021 to June 2022. Of these, 90 patients underwent RA-TKA and were included in robot-assisted system (RAS) group, while the remaining 90 patients underwent conventional TKA and were included in the conventional group. The learning curve for the RA-TKA system was evaluated by cumulative sum (CUSUM) and risk-adjusted cumulative sum (RA-CUSUM) methods. Depending on the learning curve data, the RAS group patients were categorized as either in a learning or proficiency group. In addition, the proficiency group was compared with the conventional group using propensity score matching. There was no significant difference in postoperative Hip–Knee–Ankle (HKA) angle, or deviations in the postoperative HKA angle, component tibial coronal angle (CTCA), component femoral coronal angle (CFCA), sagittal tibial component angle (STCA), or sagittal femoral component angle (SFCA) between the learning and proficiency phases in RA-TKA group patients. A total of 49 patients in the proficiency group were matched with 49 patients from the conventional group. The indicators representing the accuracy of the prosthetic installation differ between the proficiency group and conventional group. (P < 0.05). From the learning curve data, 20 cases are required for a surgeon using a novel seven-axis RA-TKA system to enter the proficiency phase. In the proficiency group, compared with the conventional group using propensity score matching, the RAS was found to be superior to the conventional group in prosthesis and lower limb alignment.
Prevention of in Situ Recurrence and Distant Metastasis in Feline Mammary Carcinoma Treated with Plasmonic Photothermal Therapy
Authors: Elsabagh Rasha H. , Farghali Haithem A. M. , Emam Ibrahim A. , Abdelrahman Hams , Ragab Eman , Nada Abdelfattah A. , Selim Salah. A. 
Published: November 2022

Abstract

Background
Clinical studies indicated the role of Breast Cancer Stem Cells (BCSCs) with the phenotype of CD44+/CD24− and/or CD133+ in the promotion of invasive and metastatic mammary tumors. Where BCSCs are resistant against the conventional chemo and radiotherapies, the gold nanorods (AuNRs)-mediated plasmonic photothermal therapy (PPTT) selectively eradicated BCSCs. A change in CTCs number predicts response to therapy. Among felines, most of the queens with mammary carcinoma (MC) exhibit an aggressive metastatic phenotype. Thus, indicated the importance of developing a rapid, accurate and noninvasive approach for prediction and monitoring of metastasis in cats. In this study, we investigated for the first time the anti-tumor activity of AuNRs PPTT by Flow Cytometry Analysis (FCA) of the circulatory BCSCs in cats with spontaneous metastatic and non-metastatic forms of MC.
Methods
The PPTT was applied on each animal in this investigation either alone (GA) or in combination with mastectomy (GB). PB was collected from all diseased cats before the treatment and 2 weeks after every PPTT cycle. BCSCs were identified in each sample as CD133+ in one test and CD44+/CD24− combination in another test using the FCA. Cells counts were compared between groups and across time. The correlation between BCSCs values and metastasis was evaluated using Spearman's correlation test. Survival analysis was performed, and prognostic cutoff points were established using ROC analysis.
Results
With survival rate of 50%, the non-metastatic cats in GA revealed complete tumor ablation 6–8 weeks of treatment and complete wound healing in GB, no in situ recurrence or distant metastasis over the observation period with a statistically significant drop in cBCSCs counts (P = 0.00512). Progression-free survival (PFS) was of a mean of 9 months (GA) and 6.6 months (GB) with median overall survival (OS) of 10.5 months (GA) and 9.5 months (GB). Lung metastasis persisted in metastatic cats in GA &GB with short PFS of 4 months. Prognostic significant cutoff values were > 996 for (CD44+/CD24−) phenotypes and > 110 for CD133+ cells.
Conclusion
BCSCs are highly susceptible to PPTT in non-metastatic queens unlike the metastatic cats as a treatment modification is required to systemically deliver the AuNRs to the metastatic sites. FC enumeration of cTCs with the CD44+/CD24− or CD133+ phenotypes has a prognostic value as an accurate and non-invasive method for therapy monitoring in FMC.
Bacterial Leaf Spot of Tomato (Solanum lycopersicum) detection using Image Processing and Convolution Neural Network
Authors: CV Aravinda , Shah Mohd Asif , Shetty Jyothi , Kini Anitha , Shetty Saritha , Lin Meng 
Published: November 2022

Abstract
In many regions of the world, lack of infrastructure makes it challenging to promptly assess plant diseases, which is a major threat to agricultural output. Recognizing disease on crops is an essential and tedious operation in agricultural techniques. It requires a significant period of time as well as skilled effort. Convolutional Neural Networks (CNNs) are the state-of-the-art in image detection, so they can produce a clear and precise assessment. Image classification in farming is becoming feasible due to the new transformation in device adoption and computer vision models. Combining computer vision and deep learning models, this paper proposes an intelligent and efficient approach for detecting crop damage. The objective of the proposed paper is to use leaves of tomatoes to identify bacterial infections. In agriculture, it is essential to diagnose pathogens as quickly as possible. We designed a convolutional neural network model to detect the problem in real time. Our model was able to identify both normal and infected tomatoes. For training purposes, we have 18,345 images in each category approximately 1000 images for each to test our model.On a held-out test set, the trained model achieves an accuracy of 96.35 \%, demonstrating the validity of this methodology.
Machine learning algorithm to predict mortality in Critically Ill Patients With Sepsis-Associated Acute Kidney Injury
Authors: Li Xunliang , Wu Ruijuan , Zhao Wenman , Shi Rui , Zhu Yuyu , Wang Zhijuan , Pan Haifeng , Wang Deguang 
Published: November 2022

Abstract
Background
This study aimed to establish and validate a machine learning (ML) model for predicting in-hospital mortality in patients with sepsis-associated acute kidney injury (SA-AKI).
Methods
This study collected data on SA-AKI patients from 2008 to 2019 using the Medical Information Mart for Intensive Care IV. After employing Lasso regression for feature selection, six ML approaches were used to build the model. The optimal model was chosen based on precision and area under curve (AUC). In addition, the best model was interpreted using SHapley Additive exPlanations (SHAP) values and Local Interpretable Model-Agnostic Explanations (LIME) algorithms.
Results
There were 8,129 sepsis patients eligible for participation; the median age was 68.7 (interquartile range: 57.2–79.6) years, and 57.9% (4,708/8,129) were male. After selection, 24 of the 44 clinical characteristics gathered after intensive care unit admission remained linked with prognosis and were utilized developing ML models. Among the six models developed, the eXtreme Gradient Boosting (XGBoost) model had the highest AUC, at 0.794. According to the SHAP values, the sequential organ failure assessment score, respiration, simplified acute physiology score II, and age were the four most influential variables in the XGBoost model. Individualized forecasts were clarified using the LIME algorithm.
Conclusions
We built and verified ML models that excel in early mortality risk prediction in SA-AKI and the XGBoost model performed best.
Virtual Physical Education: Google Meet as an alternative tool for skill-based concepts
Authors: Lobo Joseph 
Published: November 2022

Abstract

Google Meet is a videoconferencing application integrated with Google Classroom that may be used for synchronous classes. As supported by previous scholars, it is one of the most widely used videoconferencing applications globally. To assess this claim in the current setting of this investigation, the study is focused on exploring the factors that affect students’ acceptance of Google Meet as an alternative learning tool in learning skill-based concepts in Physical Education adapting the Technology Acceptance Model (TAM). After obtaining data from 250 Bachelor of Physical Education students, and after using Partial Least Square-Structural Equation Modeling (PLS-SEM), the results revealed that: (1) perceived ease of use positively predicts perceived usefulness, (2) perceived ease of use and perceived usefulness positively influences students’ behavioral intention to use, and (3) behavioral intention to use positively predicts the actual use of Google Meet. The findings posited that PEOU and PU are the external factors that affect students’ behavioral intention and actual use of the platform in learning skill-based concepts in Physical Education. Since the study setting is still in a full-online learning modality, the statistics will be used as a deciding factor by the Physical Education Department and college administration if the said platform can continuously be used in all courses in PE. Recommendations and future research directions are also presented.
Decreased circulating levels of angiopoietin – 1 (Ang-1) are associated with the presence of benign or malignant thyroid disease.
Authors: Nixon Alexander Michael , Provatopoulou Xenia , Kalogera Eleni , Zografos George Nikolaos , Bouklas Dimitrios , Philippou Anastasios , Koutsilieris Michael 
Published: November 2022

Abstract
Purpose
The aim of this study was to investigate whether the presence of benign or malignant nodular thyroid disease affects levels of circulating angiogenesis cytokines.
Methods
In this study we investigated levels of angiopoietin – 1 and − 2 (Ang-1 and Ang-2 respectively), vascular endothelial growth factor –A (VEGF-A), galectin-3 (Gal-3), urokinase plasminogen activator receptor (uPAR) and plasminogen activation inhibitor – 1 (PAI-1) in 40 patients with differentiated thyroid cancer (DTC), 45 with thyroid papillary microcarcinoma (mPTC), 53 patients with multinodular goiter (MNG) and 58 controls. Six months after surgery 28 patients resubmitted blood samples. Results: Statistically significant lower levels of Ang-1 were observed in DTC, mPTC and MNG patients compared to controls (p < .05, p < .05 and p < .001 respectively). No significant differences were observed in the levels of the other factors. A significant increase in Ang-1 levels (p < .05) was documented in the subset of patients that underwent thyroidectomy. Thyroidectomy did not influence levels of the other factors.
Conclusion
Our results suggest an association between low levels of Ang-1 and the presence of underlying benign or malignant nodular thyroid disease., while levels of the other studied cytokines are not associated.
A novel agonist-antagonist myoneural interface surgical approach on the proprioceptive reconstruction of rat lower extremity
Authors: Wang Ping , Huang Jianping , Wei Jingjing , Yu Qianhengyuan , Li Guanglin , Yang Lin , Liu Zhiyuan 
Published: November 2022

Abstract
Background
There is no consensus on the approach of agonist-antagonist myoneural interface (AMI) surgery for its effectiveness in repairing proprioception.
Objective
To investigate the effect of a novel AMI approach on proprioceptive reconstruction and motor repairion of rat lower extremity.
Methods
Sprague-Dawley rats were randomly divided into AMI group and control group. AMI group rats were treated with the novel AMI surgical, which is characterized by the fixing of soleus muscle to the surface of biceps femoris muscle, following by anastomosing tibial nerve and common peroneal nerve to soleus muscles and suturing the two tendon terminals of soleus muscle. Control group rats were treated with the same process as AMI group except tendon terminal suture. Both electrophysiological, behavioral and immunohistochemical methods were applied to evaluate the difference.
Results
The functional index of sciatic nerve, tibial nerve and common peroneal nerve, as well as step angle and body angle in AMI group were significantly lower than control group after surgery (P < 0.05). The duration of walking swing, braking, propulsion and stance in AMI group were shorter than control group (P < 0.05). The mean pressure-touch intensity of the left paw in AMI group was less than control group. The nerve compound action potential (CNAP) of tibial nerve (common peroneal nerve) and muscle compound action potential (CMAP) of gastrocnemius muscle (tibialis anterior muscle) were stronger in AMI group.
Conclusion
These results suggested that the proposed surgical method can significantly improve the postoperative walking stability and muscle synergism in rats. In addition, due to the adoption of graft, donor selection avoids the limition of nerve dissection condition, which can be extended to the whole body.