bluuebunny/crossref_metadata_2025_split huggingface dataset:
INOVASI PELAYANAN PUBLIK MELALUI APLIKASI SMART CAMPUS DATA BASE (SCDB) DI KAMPUS INSTITUT PEMERINTAHAN DALAM NEGERI
Authors: Putri Lusy Riadina 
Published: March 2022

Service is one of the duties and functions of the profession of the State Civil Servant (ASN), as a state servant and ASN community servant has several main tasks and functions, one of which is public service. Public services become the main face of the Government as the organizer of bureaucracy, good or bad public services from the Government will get a direct assessment by the public as consumers of public services. The Institute of Government of Home Affairs (IPDN) as one of the government agencies to made ASN cadres of Home Affairs government creates a public service innovation through the Smart Campus Data Base (SCDB) application as one of the containers of public services today and services for IPDN academic community interns. SCDB application is the provision of the latest data or databases and electronic information that is integrated online and can be easily accessed in general, especially by the academic community to obtain data and information about IPDN. The research method used is a descriptive type Qualitative research method. The existence of technological changes in the industrial era 4.0 is getting faster, to be able to keep up with the development of this technology IPDN must have a database where all data or information related to IPDN can be accessed directly through SCDB, the constraints in the human resources admin data manager from each unit/part in IPDN, especially in the field of informatics engineering as the person in charge of data input, IPDN needs for good cooperation for the integration of data in IPDN can run optimally to provide smoothness of the general public and academic community in accessing various information needed through the Smart Campus Data Base (SCDB) Application.
Keywords: Public Service, SCDB Application, Institute of Internal Government
EFEKTIVITAS SICANTIK CLOUD PADA PELAYANAN PUBLIK PERIZINAN BERBASIS E- GOVERMENT DIKABUPATEN PURWAKARTA
Authors: Nurrahman Agung , Rahman Jamilah 
Published: March 2022

The focus of the study is the application of the Si Cantik Cloud application. The purpose of this study is to obtain a general description of the effectiveness of Si Cantik in e-government-based licensing public services in Purwakarta Regency. The research method is descriptive qualitative. The research findings indicate that there are supporting factors, namely the commitment of organizational leaders in this case as illustrated in the publication of SOPs supporting the implementation of the Si Cantik Cloud application which can have implications for clarity of information for the business community. In conclusion, on the 5 dimensions used by the author in measuring effectiveness, information is obtained that the Si Cantik Cloud application implemented by the Purwakarta Regency Investment and One Stop Integrated Service (DPMPTSP) shows that the application is quite effective in being used and utilized in the provision of licensing and non-licensing services in Indonesia. Purwakarta Regency. The author recommends that the Purwakarta Regency Government can improve socialization and assistance to the community, and develop infrastructure designs in order to strengthen the effectiveness of implementing the Si Cantik Cloud application.
Keywords: Effectiveness, Si Cantik Cloud, Public Service, E-government.
KUALITAS PELAYANAN PUBLIK DALAM PENERAPAN APLIKASI E-PBB DI BADAN PENDAPATAN DAERAH (BAPENDA) KABUPATEN PURWAKARTA
Authors: Rahmadanita Annisa , Dowa Pretty Petronella Clarita 
Published: March 2022

The purpose of the study was to obtain an overview of the quality of public services in the application of the E-PBB application at BAPENDA Purwakarta Regency. The research method used is descriptive qualitative. The findings of this study are in the tangible dimension, BAPENDA has been able to provide services that are not limited by space and time, but BAPENDA also provides physical facilities for services in utilizing the E-PBB application. In terms of reliability, the E-PBB application has been downloaded by the people of Purwakarta more than five thousand times, this shows that the people of Purwakarta Regency believe in the services provided by the district government. On the responsiveness dimension, the Purwakarta Regency Government is considered fast and precise in providing services. Meanwhile, in the assurance dimension, information was obtained that public service providers were friendly and courteous in providing services to the community. However, in the empathy dimension, there is no firm attitude taken by employees to meet the needs of the community so that tax payment services can be carried out directly by the community without having to come to the bank or payment location. The conclusion of the study is that BAPENDA Purwakarta Regency has made use of technology in making efforts to improve the quality of public services. The quality of public services provided by BAPENDA Purwakarta Regency is considered quite good, but still needs to maximize the features in the E-PBB application and consider the needs of the community, especially in terms of paying taxes that can be carried out directly.
Keywords: Public Service Quality, E-Government, E-PBB
Single-Cell Photothermal Analysis Induced by MoS2 Nanoparticles by Raman Spectroscopy
Authors: Rusciano Giulia , Capaccio Angela , Sasso Antonio , Singh Manjot , Valadan Mohammadhassan , Dell’Aversana Carmela , Altucci Lucia , Altucci Carlo 
Published: March 2022

Two-dimensional nanomaterials, such as MoS2 nanosheets, have been attracting increasing attention in cancer diagnosis and treatment, thanks to their peculiar physical and chemical properties. Although the mechanisms which regulate the interaction between these nanomaterials and cells are not yet completely understood, many studies have proved their efficient use in the photothermal treatment of cancer, and the response to MoS2 nanosheets at the single-cell level is less investigated. Clearly, this information can help in shedding light on the subtle cellular mechanisms ruling the interaction of this 2D material with cells and, eventually, to its cytotoxicity. In this study, we use confocal micro-Raman spectroscopy to reconstruct the thermal map of single cells targeted with MoS2 under continuous laser irradiation. The experiment is performed by analyzing the water O-H stretching band around 3,400 cm−1 whose tetrahedral structure is sensitive to the molecular environment and temperature. Compared to fluorescence-based approaches, this Raman-based strategy for temperature measurement does not suffer fluorophore instability, which can be significant under continuous laser irradiation. We demonstrate that irradiation of human breast cancer MCF7 cells targeted with MoS2 nanosheets causes a relevant photothermal effect, which is particularly high in the presence of MoS2 nanosheet aggregates. Laser-induced heating is strongly localized near such particles which, in turn, tend to accumulate near the cytoplasmic membrane. Globally, our experimental outcomes are expected to be important for tuning the nanosheet fabrication process.
Intravenous Transplantation of Human Hair Follicle-Derived Mesenchymal Stem Cells Ameliorates Trabecular Bone Loss in Osteoporotic Mice
Authors: Lin Longshuai , He Enjun , Wang Hongjie , Guo Weihong , Wu Zhenkai , Huang Kai , Zhao Qinghua 
Published: March 2022

Background: Hair follicles harbor a rich autologous stem cell pool and human hair follicle-derived mesenchymal stem cells (hHF-MSCs) have multi-lineage differentiation potential. Many sources of MSCs include hHF-MSCs have been attractive candidates for cell therapy, regenerative medicine and tissue engineering. The present study is to explore the effect of intravenous transplantation of hHF-MSCs on bone mass in osteoporotic mice and its mechanism, and provides prospects for clinical applications for the treatment of osteoporosis with hHF-MSCs.Methods: Physically pull out about 20 hairs with intact hair follicles from the occipital area of the scalp of healthy volunteers, and extract hair follicle-derived fibroblast-like cells. These cells were cultured and characterized in vitro. Intravenous injection of hHF-MSCs was performed on ovariectomy-induced and age-related osteoporotic SCID mice for osteoporosis treatment. The mice were sacrificed 7 weeks after the second injection and samples were collected. The long bones and L1 vertebrae were collected for micro-CT scan, histomorphometry and immunohistochemical analysis. Peripheral serum were collected for ELISA analysis and antibody array.Results: Hair follicle-derived fibroblast-like cells were defined as hHF-MSCs. Intravenous transplantation of hHF-MSCs can better restores trabecular bone mass in osteoporotic mice. The double calcein labeling assay, trap staining of bones and ELISA analysis in peripheral serum showed enhanced bone formation and weakened bone resorption after transplantation. Antibody array and immunohistochemical analysis showed that several cytokines including OPG, Wnt2b, Noggin, VCAM-1 and RANKL might be involved in this process.Conclusion: Human HF-MSCs transplantation can combat trabecular bone loss induced by menopause and aging in mice. And the above mechanism that hHF-MSCs transplantation inhibits bone resorption and promote bone formation is related to OPG, Wnt2b, VCAM-1, Noggin and RANKL.
Hollow CoS/C Structures for High-Performance Li, Na, K Ion Batteries
Authors: Liu Yan , Li Xiangkun , Zhang Fengling , Zhang Leqing , Zhang Tao , Li Changshuan , Jin Zhicheng , Wu Yueying , Du Zhongyu , Jiao Huiwen , Jiang Ying , Yan Yuliang , Li Qiang , Kong Weijin 
Published: March 2022

Alkali ion (Li, Na, and K) batteries as a new generation of energy storage devices are widely applied in portable electronic devices and large-scale energy storage equipment. The recent focus has been devoted to develop universal anodes for these alkali ion batteries with superior performance. Transition metal sulfides can accommodate alkaline ions with large radius to travel freely between layers due to its large interlayer spacing. Moreover, the composite with carbon material can further improve electrical conductivity of transition metal sulfides and reduce the electron transfer resistance, which is beneficial for the transport of alkali ions. Herein, we designed zeolitic imidazolate framework (ZIF)–derived hollow structures CoS/C for excellent alkali ion (Li, Na, and K) battery anodes. The porous carbon framework can improve the conductivity and effectively buffer the stress-induced structural damage. The ZIF-derived CoS/C anodes maintain a reversible capacity of 648.9, and 373.2, 224.8 mAh g−1 for Li, Na, and K ion batteries after 100 cycles, respectively. Its outstanding electrochemical performance is considered as a universal anode material for Li, Na, and K ion batteries.
The Roles of Fractionated Potentials in Non-Macroreentrant Atrial Tachycardias Following Atrial Fibrillation Ablation: Recognition Beyond Three-Dimensional Mapping
Authors: Wang Yu-Chuan , Shi Li-Bin , Chu Song-Yun , Solheim Eivind , Schuster Peter , Chen Jian 
Published: March 2022

IntroductionNon-macroreentrant atrial tachycardia (nAT) following atrial fibrillation (AF) ablation is being increasingly reported. Many issues remain to be elucidated. We aimed to characterize the fractionated potentials (FPs) in nAT and introduce a new method of cross-mapping for clarifying their roles.Methods and ResultsForty-four nATs in 37 patients were enrolled and classified into focal AT (FAT, 12), microreentrant AT (MAT, 14), and small-loop-reentrant AT (SAT, 18) groups, according to activation pattern. FP was found on all targets except in nine FATs. The ratio of FP duration to AT cycle length (TCL) was different among groups (28 ± 7% in FAT, 53 ± 11% in MAT, and 42 ± 14% in SAT, p &lt; 0.05), and ablation duration were longer in SATs (313 ± 298 vs. 111 ± 125 s, p &lt; 0.05). The ratio of mappable cycle length to TCL was lower in the FAT group (63 ± 22% vs. 90 ± 9% and 89 ± 8%, p &lt; 0.05). When cross-mapping was employed, trans-potential time differences in both longitudinal and transverse direction were longer around the culprit FP for MAT (p &lt; 0.01). After Receiver Operating Characteristic curve analysis, it is best to adopt the sum of time difference ratios in both directions ≥60% as a cut-off value for discrimination of the FPs responsible for MAT with a sensitivity of 92% and specificity of 87%.ConclusionsFP could be found on target in most nATs following a previous AF ablation. The ratio of FP duration to TCL may help for differentiation. A simple method of cross-mapping could be employed to clarify the roles of FPs.
Association of Neutrophil to Lymphocyte Ratio With Plaque Rupture in Acute Coronary Syndrome Patients With Only Intermediate Coronary Artery Lesions Assessed by Optical Coherence Tomography
Authors: Jiang Jintong , Zeng Huasu , Zhuo Yang , Wang Changqian , Gu Jun , Zhang Junfeng , Zhang Huili 
Published: March 2022

ObjectivesPlaque vulnerability and rupture rather than plaque size are the major cause of clinical events in patients with intermediate coronary lesions. Therefore, the present study was aimed to explore potential markers associated with plaque rupture in acute coronary syndrome (ACS) patients with intermediate coronary lesions.MethodsA total of 82 ACS patients presenting with only intermediate coronary lesions (40–70% stenosis demonstrated by quantitative coronary angiography) and no severe stenosis in other main coronary arteries [median age 63 years, 53 male and 29 female] were enrolled. Plaque morphology were assessed by optical coherence tomography (OCT). Hematological indices were assayed by automated hematological analyzer.ResultsPlaque rupture was identified in 14 patients by OCT. Neutrophil to lymphocyte ratio (NLR) in patients with plaque rupture (n = 14) was significantly higher than that in patients with non-plaque rupture (n = 68) [3.85 (3.28, 4.77) vs. 2.13 (1.40, 2.81), p &lt; 0.001]. Multivariate logistic regression analysis revealed that NLR was one of the independent risk factors for plaque rupture in intermediate coronary artery lesions (odds ratio 1.64, 95% confidence intervals 1.18–2.29, p = 0.003). ROC curve analysis found a cutoff point of NLR &gt; 2.94 for plaque rupture with 93.8% sensitivity and 77.9% specificity.ConclusionNLR, an inflammatory biomarker, is closely associated with plaque rupture in intermediate coronary artery lesions. Monitoring NLR may be useful in risk stratification and management for intermediate coronary artery lesions.
Concomitant Atrial Fibrillation Procedures During Cardiac Surgery in a UK Center: Reflection of Worldwide Practice?
Authors: Mistirian Alina-Adriana , Yates Martin T. , Awad Wael I. 
Published: March 2022

BackgroundGuidelines recommend concomitant atrial fibrillation (AF) ablation during cardiac surgery to restore normal sinus rhythm (NSR). The study determines, to what extent patients with AF undergoing cardiac surgery at our institution received a concomitant AF procedure, what these procedures entailed, and short-term outcomes.MethodsA retrospective study of 2,984 patients undergoing cardiac surgery over 18 months. Patients who were in preoperative AF were identified and those who underwent a concomitant AF procedure (Group 1) were compared with those who did not (Group 2).ResultsThree hundred and thirteen (10.5%) patients had pre-operative AF; paroxysmal (19.5%), persistent (11.8%), longstanding (63%), unknown (5.8%). 116/313 (37.1%) patients had a concomitant AF procedure: 7.7% patients had a concomitant AF ablation and 29.4% had only a Left Atrial Appendage Occlusion (LAAO). Fewer patients with paroxysmal and persistent AF underwent concomitant AF procedures compared with the ones who had no AF procedures (6.7 vs. 12.8% and 17.6 vs. 31%, respectively). Greater in-hospital survival (99.1 vs. 93.9%, p = 0.025) and survival at a mean follow up of 6 weeks (97.4 vs. 89.3%, p = 0.09) was probably determined by patient's preoperative comorbidities. There were no differences in readmission rates, permanent pacemaker insertion, cerebral events or NSR at discharge or follow-up, between groups.ConclusionsIn our center, concomitant AF ablation is performed only in 7.7% of cases, 29.4% had only an LAAO performed at the time of surgery. There was no difference in restoring NSR, cerebral events, or readmission rates compared with patients who had nothing done for their preoperative AF.
Three-Dimensional Radiomics Features of Magnetic Resonance T2-Weighted Imaging Combined With Clinical Characteristics to Predict the Recurrence of Acute Pancreatitis
Authors: Hu Yuntao , Liu Nian , Tang Lingling , Liu Qianqian , Pan Ke , Lei Lixing , Huang Xiaohua 
Published: March 2022

ObjectiveTo explore the diagnostic value of radiomics model based on magnetic resonance T2-weighted imaging for predicting the recurrence of acute pancreatitis.MethodsWe retrospectively collected 190 patients with acute pancreatitis (AP), including 122 patients with initial acute pancreatitis (IAP) and 68 patients with recurrent acute pancreatitis (RAP). At the same time, the clinical characteristics of the two groups were collected. They were randomly divided into training group and validation group in the ratio of 7:3. One hundred thirty-four cases in the training group, including 86 cases of IAP and 48 cases of RAP. There were 56 cases in the validation group, including 36 cases of IAP and 20 cases of RAP. Least absolute shrinkage and selection operator (LASSO) were used for feature screening. Logistic regression was used to establish the radiomics model, clinical model and combined model for predicting AP recurrence. The predictive ability of the three models was evaluated by the area under the curve (AUC). The recurrence risk in patients with AP was assessed using the nomogram.ResultsThe AUCs of radiomics model in training group and validation group were 0.804 and 0.788, respectively. The AUCs of the combined model in the training group and the validation group were 0.833 and 0.799, respectively. The AUCs of the clinical model in training group and validation group were 0.677 and 0.572, respectively. The sensitivities of the radiomics model, combined model, and clinical model were 0.646, 0.691, and 0.765, respectively. The specificities of the radiomics model, combined model, and clinical model were 0.791, 0.828, and 0.590, respectively. There was no significant difference in AUC between the radiomics model and the combined model for predicting RAP (p = 0.067). The AUCs of the radiomics model and combined model were greater than those of the clinical model (p = 0.008 and p = 0.007, respectively).ConclusionsRadiomics features based on magnetic resonance T2WI could be used as biomarkers to predict the recurrence of AP, and radiomics model and combined model can provide new directions for predicting recurrence of acute pancreatitis.
Comparative Study of Relative Peripheral Refraction in Children With Different Degrees of Myopia
Authors: Xiaoli Lu , Xiangyue Zheng , Lihua Lian , Yuting Huang , Chuni Lin , Yujie Xia , Zhao Wang , Xiaoyi Yu 
Published: March 2022

PurposeTo investigate the difference in the retinal refraction difference value (RDV) using multispectral refractive topography (MRT).MethodsNinety myopic participants, who met the enrolment requirements, were examined with an automatic optometer after mydriasis. According to the value of the spherical equivalent (SE), the participants were divided into Emmetropia group (E, +0.5D &lt; SE &lt; −0.5D), Low Myopia (LM, −0.5D &lt; SE ≤ −3D), and Moderate and high Myopia (MM, −3D &lt; SE ≤ −10D). The ocular biological parameters were detected by optical biometrics (Lenstar 900, Switzerland), including axial length (AL), lens thickness (LT), and keratometry (K1, K2). Furthermore, the MRT was used to measure the retinal RDV at three concentric areas, with 15-degree intervals from fovea into 45 degrees (RDV-15, RDV 15–30, and RDV 30–45), and four sectors, including RDV-S (RDV-Superior), RDV-I (RDV-Inferior), RDV-T (RDV-Temporal), and RDV-N (RDV-Nasal).ResultsIn the range of RDV-15, there was a significant difference in the value of RDV-15 between Group E (−0.007 ± 0.148) vs. Group LM (−0.212 ± 0.399), and Group E vs. Group MM (0.019 ± 0.106) (P &lt; 0.05); In the range of RDV 15–30, there was a significant difference in the value of RDV 15–30 between Group E (0.114 ± 0.219) vs. Group LM (−0.106 ± 0.332), and Group LM vs. Group MM (0.177 ± 0.209; P &lt; 0.05); In the range of RDV 30–45, there was a significant difference in the value of RDV 30–45 between Group E (0.366 ± 0.339) vs. Group LM (0.461 ± 0.304), and Group E vs. Group MM (0.845 ± 0.415; P &lt; 0.05); In the RDV-S position, there was a significant difference in the value of RDV-S between Group LM (−0.038 ± 0.636) and Group MM (0.526 ± 0.540) (P &lt; 0.05); In the RDV-I position, there was a significant difference in the value of RDV-I between Group E (0.276 ± 0.530) vs. Group LM (0.594 ± 0.513), and Group E vs. Group MM (0.679 ± 0.589; P &lt; 0.05). In the RDV-T position, there was no significant difference in the value of RDV-T among the three groups. In the RDV-N position, there was a significant difference in the value of RDV-N between Group E (0.352 ± 0.623) vs. Group LM (0.464 ± 0.724), and Group E vs. Group MM (1.078 ± 0.627; P &lt; 0.05). The RDV analysis in all directions among the three groups showed a significant difference between RDV-S and RDV-I in Group LM (P &lt; 0.05). Moreover, the correlation analysis showed that SE negatively correlated with AL, RDV 30–45, RDV-S, RDV-I, and RDV-N.ConclusionsIn this study, there was a significant difference in the value of RDV among Group E, Group LM, and Group MM, and the value of RDV in Group MM was the highest on the whole. In the range of RDV 30–45, there was a growing trend with the increase in the degree of myopia among the three groups. Furthermore, the SE negatively correlated with AL, RDV 30–45, RDV-S, RDV-I, and RDV-N.
Acute Exacerbation of Rheumatoid Arthritis Misdiagnosed as COVID-19: A Case Report
Authors: Torun Serife , Karaman Irem 
Published: March 2022

BackgroundRheumatoid arthritis (RA) is a systemic inflammatory connective tissue disease that affects 1–2% of the population worldwide. Pulmonary manifestations including interstitial lung disease (ILD), airway disease, pleural and vascular disease can be seen in up to 30–40% of patients with RA, which are recognized as the second most frequent cause of death in RA patients. The simultaneous occurrence of COVID-19 in RA patients with or without ILD, and the similarities and differences between RA-related ILD and COVID-19 lung findings have been reported in the literature. However, there was no reported case on differentiation of clinical findings of a patient with RA exacerbation causing a new diagnosis of ILD during the pandemic conditions.Case PresentationHere, we presented a patient with RA who was misdiagnosed as COVID-19 twice due to non-specific respiratory symptoms and ground-glass opacities observed in high-resolution CT. The misdiagnosis led to a delayed diagnosis of ILD and prolonged pulmonary symptoms.DiscussionClinicians must critically review patients throughout the diagnostic workup by thinking other diseases besides COVID-19, particularly in the absence of a confirmatory result. The link between ILD or ILD exacerbation and COVID-19 remains to be determined. While research continues in the field, it is important to consider the importance of COVID-19 in cases of ILD exacerbation, and vice versa.ConclusionDistinguishing lung imaging findings of COVID-19 from ILD is a major concern. Even though the primary manifestation of COVID-19 consists of respiratory symptoms, clinicians should be vigilant for other common conditions having the same symptoms. Clinicians should carefully distinguish a differential diagnosis between COVID-19 and a flare of rheumatic disease.