bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expectant mothers and fathers' knowledge of nurturing care in a developing country
Authors: Soysal Cimen Hafize , Karaaslan Bedriye Tugba 
Published: November 2022

BackgroundThe Nurturing Care Framework (NCF), which has been emphasized by the World Health Organization (WHO) in recent years and is among the United Nations Sustainable Development Goals (SDGs), expresses the conditions created to promote early childhood development (ECD). These conditions aim to provide opportunities for children in the Good Health, Adequate Nutrition, Responsive Caregiving, Security and Safety, and Opportunities for Early Learning (5 Components) by caregivers, primarily from low and middle-income countries (LMICs). The aim of this study is to examine the knowledge and awareness of expectant mothers and fathers in Turkey, about the NCF.MethodsIn this study, a cross-sectional, analytical research design was used. Nurturing Care (NC) knowledge and awareness levels of expectant mothers and fathers in the 2nd and 3rd trimesters of pregnancy were determined via the online form of “The Knowledge of Nurturing Care Inventory (KNCI)” prepared by the researchers. This form consists of 60 questions describing the 5 components mentioned above. The sample contains a total of 103 people, 91 (88.3%) women, and 12 (11.7%) men.ResultsAmong the findings, the highest mean of knowledge level (13.76 ± 1.22) was found in Responsive Caregiving, and the lowest mean of knowledge level (4.35 ± 1.83) was found in Opportunities for Early Learning. The general level of knowledge on NC was found to vary statistically significantly depending on gender in favor of the women [t(101) = 3.27, p &lt; .05], depending on educational status in favor of those with university and graduate education [F(2, 100) = 3.481, p &lt; .05], depending on participation in pregnancy school training in favor of those who attended [t(101) = 2.349, p &lt; .05], and depending on knowledge on how to support development in favor of those who know how to support [t(101) = 2.370, p &lt; .05].ConclusionsAs a result, expectant parents need information and support about the period when children can acquire the basic developmental milestones and about the developmental risk indicators. More research is needed to implement the NCF starting from the preconception period, especially in LMICs, so that the opportunities in early childhood (which is the time period when the brain architecture is shaped, and development is the fastest) are not missed.
Gypenosides ameliorate ductular reaction and liver fibrosis via inhibition of hedgehog signaling
Authors: Hu Yonghong , He Xiaoli , Zhou Xiaoxi , Liang Yue , Fu Yadong , Zhang Linzhang , Fang Jing , Liu Wei , Chen Gaofeng , Mu Yongping , Zhang Hua , Cai Hong , Liu Chenghai , Liu Ping , Chen Jiamei 
Published: November 2022

Backgroud and aims: Ductular reaction (DR) is a common pathological change and thought to have a key role in the pathogenesis and progression of liver fibrosis. Our previous study reported Gypenosides (GPs) ameliorated liver fibrosis, however, the anti-fibrotic mechanisms of GPs are still unclear.Methods: Liver fibrosis was induced in rats by carbon tetrachloride combining with 2-acerylaminofluorene (CCl4/2-AAF), and Mdr2 knockout (Mdr2−/−) mice to evaluate the anti-fibrotic role of GPs. In vitro, WB-F344 cells, a hepatic progenitor cells (HPCs) line, with or without Gli1 overexpressing lentiviral vectors, were induced by sodium butyrate (SB) to validate the mechanism of GPs and NPLC0393, the main ingredient of GPs.Results: Both in CCl4/2-AAF-treated rats and Mdr2−/− mice, GPs obviously reduced the deposition of collagen and hydroxyproline content, inhibited the activation of hepatic stellate cells and inflammatory cell infiltration. Notably, GPs reduced the expressions of Epcam, CK19, CK7, Dhh, Smo, Ptch2, Gli1 and Gli2. Furthermore, CK19+ cells co-expressed Gli1, while the number of CK19+/Gli1+ cells was decreased by GPs. In vitro, GPs and NPLC0393 inhibited the differentiation of WB-F344 cells toward a biliary phenotype. Mechanistically, GPs and NPLC0393 protected against DR by inhibiting hedgehog signaling, which was supported by the results that DR, triggered directly by Gli1 overexpressing lentiviral vector was blocked by administration with GPs or NPLC0393.Conclusion: GPs attenuated DR and liver fibrosis by inhibiting hedgehog signaling, which provided more evidences and a novel mechanism of anti-fibrotic effect of GPs.
Association between type 1 diabetes and neurodevelopmental disorders in children and adolescents: A systematic review and meta-analysis
Authors: Xie Xue-Ni , Lei Xue , Xiao Chun-Ye , Li Ya-Min , Lei Xian-Yang 
Published: November 2022

Type 1 diabetes and neurodevelopmental disorders are common chronic conditions in childhood and adolescence, and having one may lead to an increased chance of developing the other. Type 1 diabetes mellitus is mainly manifested by elevated blood glucose, while neurodevelopmental diseases are composed of a variety of diseases, which are relatively complex. The purpose of this meta-analysis was to find out the prevalence of type 1 diabetes-related neurodevelopmental disorders in children and adolescents and to explore the potential association between neurodevelopmental disorders and type 1 diabetes. PubMed, Embase and Web of science databases were searched from the inception to May 22, 2022 to identify relevant studies, Finally, 24 original studies were included in the meta-analysis. Prevalence estimates for neurodevelopmental disorders in the type 1 diabetes adolescent and their 95% confidence intervals were pooled using random effects models. The pooled estimates for autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD) in the type 1 diabetes population were 1.2 and 5.3%, respectively, both of which are higher than the 2019 global prevalence of ASD and ADHD in the general population. The results of the subgroup analysis showed that the prevalence of ASD and ADHD in the T1DM population tended to increase with age. In conclusion, there may be a potential link between the occurrence of type 1 diabetes mellitus and the development of neurodevelopmental disorders in children and adolescents, but more relevant studies are needed to understand the link between the underlying pathogenesis of type 1 diabetes and neurodevelopmental disorders.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO/], identifier [CDR42022333443].
Empirical evidence on structural racism as a driver of racial inequities in COVID-19 mortality
Authors: Brown Tyson H. , Kamis Christina , Homan Patricia 
Published: November 2022

ObjectiveThis study contributes to the literature by empirically testing the extent to which place-based structural racism is a driver of state-level racial inequalities in COVID-19 mortality using theoretically-informed, innovative approaches.MethodsCDC data are used to measure cumulative COVID-19 death rates between January 2020 and August 2022. The outcome measure is a state-level Black-White (B/W) ratio of age-adjusted death rates. We use state-level 2019 administrative data on previously validated indicators of structural racism spanning educational, economic, political, criminal-legal and housing to identify a novel, multi-sectoral latent measure of structural racism (CFI = 0.982, TLI = 0.968, and RMSEA = 0.044). We map B/W inequalities in COVID-19 mortality as well as the latent measure of structural racism in order to understand their geographic distribution across U.S. states. Finally, we use regression analyses to estimate the extent to which structural racism contributes to Black-White inequalities in COVID-19 mortality, net of potential confounders.ResultsResults reveal substantial state-level variation in the B/W ratio of COVID-19 death rates and structural racism. Notably, regression estimates indicate that the relationship between the structural racism and B/W inequality in COVID-19 mortality is positive and statistically significant (p &lt; 0.001), both in the bivariate model (adjusted R2 = 0.37) and net of the covariates (adjusted R2 = 0.54). For example, whereas states with a structural racism value 2 standard deviation below the mean have a B/W ratio of approximately 1.12, states with a structural racism value 2 standard deviation above the mean have a ratio of just above 2.0.DiscussionFindings suggest that efficacious health equity solutions will require bold policies that dismantle structural racism across numerous societal domains.
Schinus terebinthifolius Leaf Lectin (SteLL) Reduces the Bacterial and Inflammatory Burden of Wounds Infected by Staphylococcus aureus Promoting Skin Repair
Authors: Nunes Marcio Anderson Sousa , Silva Lucas dos Santos , Santos Deivid Martins , Cutrim Brenda da Silva , Vieira Silvamara Leite , Silva Izadora Souza Soeiro , Castelo Branco Simeone Júlio dos Santos , Nascimento Mayara de Santana do , Vale André Alvares Marques , Santos-Azevedo Ana Paula Silva dos , Zagmignan Adrielle , Sousa Joicy Cortez de Sá , Napoleão Thiago Henrique , Paiva Patrícia Maria Guedes , Monteiro-Neto Valério , Nascimento da Silva Luís Cláudio 
Published: November 2022

Staphylococcus aureus is commonly found in wound infections where this pathogen impairs skin repair. The lectin isolated from leaves of Schinus terebinthifolius (named SteLL) has antimicrobial and antivirulence action against S. aureus. This study evaluated the effects of topical administration of SteLL on mice wounds infected by S. aureus. Seventy-two C57/BL6 mice (6–8 weeks old) were allocated into four groups: (i) uninfected wounds; (ii) infected wounds, (iii) infected wounds treated with 32 µg/mL SteLL solution; (iv) infected wounds treated with 64 µg/mL SteLL solution. The excisional wounds (64 mm2) were induced on the dorsum and infected by S. aureus 432170 (4.0 × 106 CFU/wound). The daily treatment started 1-day post-infection (dpi). The topical application of both SteLL concentrations significantly accelerated the healing of S. aureus-infected wounds until the 7th dpi, when compared to untreated infected lesions (reductions of 1.95–4.55-fold and 1.79–2.90-fold for SteLL at 32 µg/mL and 64 µg/mL, respectively). The SteLL-based treatment also amended the severity of wound infection and reduced the bacterial load (12-fold to 72-fold for 32 µg/mL, and 14-fold to 282-fold for 64 µg/mL). SteLL-treated wounds show higher collagen deposition and restoration of skin structure than other groups. The bacterial load and the levels of inflammatory markers (IL-6, MCP-1, TNF-α, and VEGF) were also reduced by both SteLL concentrations. These results corroborate the reported anti-infective properties of SteLL, making this lectin a lead candidate for developing alternative agents for the treatment of S. aureus-infected skin lesions.
Prevalencia y comorbilidades de retinopatía en una institución especializada en Armenia - Colombia
Authors: Nieto-Cárdenas Olga Alicia , Ariza-Pardo Oscar , Duque-Cardona María José , Millán-Taborda Jorge Luis , Bernal-Urrego Javier Andrés 
Published: November 2022

Introducción: La retinopatía hipertensiva y retinopatía diabética constituyen un problema de salud pública porque generan discapacidad visual evitable, sin embargo, se desconoce la prevalencia actual, sus factores asociados en la región y su situación en el marco de las Rutas de Atención Integral en Salud (RIAS) para la hipertensión y la diabetes que tienen establecida la remisión a oftalmología como seguimiento de daño a órgano blanco.
Objetivo: Describir las características y comorbilidades de la retinopatía Hipertensiva y Diabética, en pacientes que consultaron a oftalmología en el Quindío durante el año 2018.
Métodos: Se realizó un estudio descriptivo de corte transversal, con base en las historias de pacientes que consultaron a una institución especializada del Quindío durante el año 2018. Se describieron variables en promedio, desviación estándar e intervalos de confianza, se hizo un análisis comparativo por sexo, se realizaron análisis de varianza y Chi cuadrado.
Resultados: La prevalencia de retinopatía diabética fue de 1,65% y de retinopatía hipertensiva del 0,22%. El 62,06% presentó retinopatía diabética no proliferativa (RDNP) y el 37,93% retinopatía diabética proliferativa (RDP).
Conclusiones: Se identifica más retinopatía diabética y la retinopatía hipertensiva casi no se diagnostica. Y el número de pacientes que consultan por enfermedades del ojo ha venido en aumento durante los últimos 3 años en un centro especializado de la ciudad de Armenia.
A Clinical Case of "Serpentine" Thrombus in the Right Atrium from the Inferior Vena Cava: A Rare Finding on Echocardiography
Authors: Тарасевич С.В. , Галицкая С.С. , Козлов О.И. , Любимова О.В. , Комаровская Е.Г. 
Published: November 2022

Тромбоз правых отделов сердца, возникающий в результате тромбоза нижней полой вены, является редким заболеванием и редкой находкой (до 0,1%) при эхокардиографии. Он остается малоизученным, поскольку реже встречается, реже диагностируется, а также может протекать бессимптомно, следовательно, может представлять диагностическую и терапевтическую проблему. В данной статье представлен клинический случай пациентки 65 лет с жалобами на боли сжимающего характера за грудиной, чувство нехватки воздуха, ощущение постоянного умеренного дискомфорта в области сердца. При проведении эхокардиографического исследования выявлен тромб в нижней полой вене, распространяющийся в правое предсердие. Последующая рентгеновская компьютерная томография позволила поставить точный диа-гноз. Выполнено хирургическое удаление тромба. Пациентка была выписана из стационара в удовлетворительном состоянии. Этот случай демонстрирует случайную находку «змеевидного» тромба в нижней полой вене и правом предсердии, а также иллюстрирует важность и дополнительную ценность эхокардиографии. Клиницисты и диагносты должны настороженно относиться к пациентам, которые находятся в зоне риска и имеют факторы, провоцирующие венозный тромбоз.
Right heart thrombosis resulting from thrombosis of the inferior vena cava is a rare disease and a rare finding (as low as 0.1%) on echocardiography. It remains understudied because of its rarer occurrence and rarer diagnosis, and also it may be asymptomatic. Therefore, thrombosis of the inferior vena cava may present a diagnostic and therapeutic problem. This article presents a clinical case of a 65-year-old female patient with complaints of compressive pain behind the sternum, a feeling of lack of air, and a feeling of constant moderate discomfort in the heart area. Echocardiography revealed a thrombus in the inferior vena cava extending into the right atrium. Subsequent X-ray computed tomography allowed to make an accurate diagnosis. The thrombus was surgically removed. The patient was discharged from the hospital in a satisfactory condition. This case demonstrates the accidental finding of a "serpentine" thrombus in the inferior vena cava and right atrium and illustrates the importance and additional value of echocardiography. Clinicians and diagnosticians should be particularly aware of patients at risk and presenting factors causing venous thrombosis.
Total Aortic Arch Endoprosthetic Repair Using Outside and In Situ Fenestration Techniques: First Results in Russia. Clinical Cases
Authors: Ахмедов У.У. , Шарафутдинов М.Р. , Якубов Р.А. , Садыков Р.З. , Хайрутдинов А.И. , Тарасов Ю.В. 
Published: November 2022

В течение последних 20 лет наблюдается явный сдвиг в сторону эндоваскулярного лечения грудного отдела аорты при различных ее патологиях. Однако полное эндоваскулярное восстановление дуги аорты остается технически сложным. В настоящее время существуют несколько методов эндоваскулярного лечения дуги: гибридный подход, тотальный эндоваскулярный дебранчинг с использованием параллельных графтов (по типу дымохода или сноркелинга) и фенестрация (произведенный в фабричных условиях hand-made in situ или outside). Первые результаты применения данных технологий восстановления дуги являются многообещающими, особенно полная замена дуги с помощью нестандартных фенестрированных или браншированных стент-графтов. Использование фенестрированных или браншированных графтов F-TEVAR и Chimney является привлекательным методом лечения заболеваний дуги аорты, однако имеет более высокую стоимость и длительность ожидания.
Over the last 20 years, a clear shift towards endovascular repair of the thoracic aorta in its various pathologies has been observed. However, complete endovascular repair of the aortic arch remains technically sophisticated. Currently, there are several methods of endovascular arch treatment: a hybrid approach, total endovascular debranching using parallel grafts (like a chimney or snorkeling) and fenestration (factory-made, hand-made (physician modified graft (PMG)) in situ or outside (on-a-table)). Early results of the application of the aortic arch repair technology are promising, especially the complete replacement of the aortic arch be means of non-standard fenestrated or branched stent grafts. Use of fenestrated or branched grafts factory F-TEVAR and Chimney is an attractive method for treating of aortic arch diseases but has a higher cost and a longer waiting time.
Reseñas Bibliográficas
Authors: Leranoz Alfonsina , Morello Juan 
Published: November 2022

Álvarez Gila, Óscar (2019). Antes de la Ikurriña. Banderas, símbolos e identidad vasca en América (1880-1935). Madrid: Sílex, 464 páginas.

Elisabeth Piller, Selling Weimar. German Public Diplomacy and the United States, 1918-1933, Stuttgart, Editorial Franz Steiner, 2021, 432 páginas.
Efek Opini Audit dan Kepemilikan Publik terhadap Ketepatan Waktu Penyampaian Laporan Keuangan.
Authors: Umar Zulkifli , Safatul Anam Budi , Nizar Gustia 
Published: November 2022

Penelitian ini bertujuan untuk menguji efek opini audit dan kepemilikan publik terhadap ketepatan waktu penyampaian laporan keuangan . Penelitian ini adalah penelitian sampel, yakni memasukan 222 perusahaan dari 547 perusahaan sektor manufaktur selama tahun pengamatan 2018-2020. Sampel dipilih dengan teknik purposive sampling. Metode analisis yang digunakan adalah regresi logistik. Hasil penelitian menemukan bahwa opini audit berpengaruh meningkatkan ketepatan waktu penyampaian laporan keuangan, khususnya opini audit wajar dengan pengecualian. Kepemilikan publik juga berpengaruh meningkatkan ketepatan waktu penyampaian laporan keuangan.
Kata kunci: Ketepatan waktu penyampaian laporan keuangan, opini audit, kepemilikan publik.
PENGARUH PERAWATAN METODE KANGURU TERHADAP PERTUMBUHAN PADA BAYI BERAT BADAN LAHIR RENDAH
Authors: Siswanti Reny , Nuraidah Nuraidah , Susanti Astri , Sari Noor Siti Noviani Indah , Wibawati Fitria Hari , Fatimah Siti 
Published: November 2022

Pendahuluan: Bayi dengan BBLR juga sangat rentan terjadinya hipotermia, karena tipisnya cadangan lemak di bawah kulit dan belum matangnya pusat pengatur panas di otak. salah satu cara mempertahankan suhu tubuh normal pada bayi BBLR adalah metode kanguru atau perawatan bayi lekat, di mana bayi selalu didekap ibu atau orang lain dengan kontak langsung kulit bayi dengan kulit ibu atau pengasuhnya dengan selalu menggendongnya. Tujuan : Penelitian ini bertujuan untuk mengetahui pengaruh perawatan metode kanguru terhadap pertumbuhan bayi berat badan lahir rendah. Metode : Desain penelitian ini menggunakan Pre Eksperimental dengan one group pretest posttest design, populasi 10 responden, sampel 10 responden dengan teknik pengambilan sampel total sampling. Instrumen yang digunakan adalah lembar observasi untuk mengamati berat badan bayi selama diberikan perawatan metode kanguru. Uji statististik yang digunakan menggunakan uji t test. Hasil : Nilai mean berat badan bayi lahir rendah sebelum perawatan dengan metode kanguru 1900 gram, sementara sesudah dilakukan perawatan metode kanguru didapatkan nilai mean 2150 gram. Hasil uji t test didapatkan nilai p = 0.000. Kesimpulan : Ada pengaruh perawatan metode kanguru terhadap pertumbuhan bayi berat badan lahir rendah
Visualización de la literatura asociada a la economía social y sus vínculos con la sostenibilidad.
Authors: ALARCÓN CONDE Miguel Ángel , ÁLVAREZ Juan Fernando , MORAIS Leandro Pereira 
Published: November 2022

La diversidad de títulos, significados y significantes asociados a la relación entre la economía social y la sostenibilidad no contribuye a la delimitación de prácticas que contribuyen a la sostenibilidad y su posible análisis de manera agregada, generando que la temática sea supuesta como un atributo inherente a las organizaciones.
Por medio de un análisis de los principales conceptos relacionados a la economía social y la sostenibilidad, sus vínculos y trayectorias comunes y la disposición de éstos bajo un Análisis de Redes Sociales, se busca visualizar la literatura académica sobre Economía Social y contribuir a la delimitación de relaciones entre términos satélites y colaterales.
Se infieren ciertas relaciones geográficas, y otras significativas entre ese conjunto de términos. Se muestra un fuerte incremento de la investigación mundial sobre el tema en los últimos 20 años respecto al crecimiento medio de las referencias científicas totales. Además, aumenta el peso de la investigación los componentes y principios de la Economía Social, así como la de paradigmas económicos emergentes. A la vez, se detecta cierta especialización geográfica por componentes. Además, desde 2015, incrementan muy notablemente las referencias sobre sostenibilidad y, así, las relacionadas con los Objetivos de Desarrollo Sostenible.
REKONSEPTUALISASI PERADILAN ADAT DALAM MENYELESAIKAN KONFLIK TANAH ULAYAT YANG BERDASARKANTRI HITA KARANA
Authors: I WAYAN EKA ARTAJAYA S.H.,M.Hum.  , I GUSTI NGURAH ANOM,S.H.,M.H.  
Published: November 2022

Rekonseptualisasi Peradilan Adat Dalam Menyelesaikan Konflik tanah Ulayat/tanah adat yang berdasarkan TriHita Karana. Penyelesaian sengketa yang dilakukan oleh peradilan adat Kerta Desa dalam menyelsaikan sengketa tanah ulayat di Bali yang mengacu pada Pasal 18 B Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 dan Peraturan Daerah Provisi No 4 Tahun 2019 tentang Desa Adat. Perlu adanya rekonseptualisisi terhadap sistem peradilan adat, mulai dari putusan peradilan adat, sistem dari peradilan adat, serta sistem aturan yang lebih tinggi, yang nantinya memberikan kekuatan hukum kepada putusan dari peradilan adat khusus sengketa tentang tanah Ulayat untuk tidak dapat diajukan Kembali kesistem peradilan negeri. Penyelesiaan sengketa tanah Ulayat diharapkan kedepannya dapat diatur dalam sistem perundang-undangan, untuk memberikan hak sepenuhnya terhadap peradilan adat untuk menyelesaikan sengketa berdasarkan filosofis dari Tri Hita Karana.
Perception of Dentists regarding Brain Drain in Punjab, Pakistan: A Cross-sectional Survey
Authors: Arooj Ul Hassan  , Naiha Muzamil  , Mehrin Wajahat  , Zunaira Iqbal  , Obaid Bajwa  
Published: November 2022

BACKGROUND & OBJECTIVE: Brain drain is a term coined for the migration of highly skilled professionals from the country of their origin to more developed countries. As the trend of moving abroad is on a rise, ever since, it is causing a shortage of dental professionals in our country. The objective of our study is to determine the factors that would compel the dentists of Punjab, Pakistan, to move abroad and how to prevent this migration.
METHODOLOGY: It was a cross-sectional survey. Data was collected through a self-constructed and validated questionnaire. The study was done in dental colleges in Punjab, and the duration of the study was one year. The questionnaire was distributed both by hand and via digital sources.
RESULTS: There were 155 (33.4%) participants, who were planning to go abroad for higher education, and 274 (59%) had not planned to go out of the country for further studies. Among the study participants, 50 (32.3%) participants were planning to move to the United Kingdom, whereas 23 (14.8%) participants were planning to go to Australia, 44 (28.3%) wanted to move to the US, 10 (6.4%) to Canada and the rest (18%) had plans to move to any other country.
CONCLUSION: The majority of dental graduates wish to go abroad for their post-graduation. The dentists of Punjab were willing to serve their country, provided the economic and political situations improved.