bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structured feedback
Authors: Kaur Daljit , Negi Gita , Jain Ashish , Meinia Sushant Kumar , Sidhu Tanvir Kaur , Rathore Bharti Bhandari 
Published: September 2022

CONTEXT:
Structured Feedback is a learning and assessment tool designed to provide feedback to students and educators to adjust learning and teaching during the training. Lack of provision of structured feedback to postgraduate (PG) medical students prompted us to plan a study to introduce a structured feedback module into the existing monthly assessment schedules in the Department of Transfusion Medicine.

AIM:
This study aims to introduce a structured feedback module and evaluate its efficacy after incorporation into the existing monthly assessment schedules for the PG students in the Department of Transfusion Medicine.

DESIGN AND SETTING:
A quasi-experimental study was commenced after obtaining clearance from the Institutional Ethics Committee in the Department of Transfusion Medicine for the students pursuing postgraduation in Transfusion Medicine.

METHODOLOGY:
A peer-validated feedback module was designed and implemented for MD students by the core team faculty. The students underwent the structured feedback sessions after each monthly assessment for of 3 months. One on one, verbal feedback was conducted using Pendleton's method, for monthly online assessment for the learning that happened during study period.

DATA COLLECTION AND STATISTICAL ANALYSIS:
The data were collected from the open-ended and closed-ended questions using Google form-based Student/Faculty perception and students’ pre-post self-efficacy questionnaires on 5-point Likert Scale and the quantitative data analysis was done using percentage of Likert scores, median values for each item for pre-and post-responses and comparison using nonparametric test – Wilcoxon signed-rank test. The qualitative data analysis was done using thematic analysis from the open ended questions.

RESULTS:
All (n = 9; 100%) the PG students strongly agreed and agreed (median score of 5 and 4) that the feedback they received made them aware of their learning gaps, enabled them in bridging those gaps and provided ample opportunity to interact with faculty. Both students and faculty agreed that the feedback session should be an ongoing and continuous process in the department.

CONCLUSION:
Both the students as well as faculty were satisfied with the implementation of the feedback module in the department. Students reported awareness about the learning gaps, identification of appropriate study resources, and ample opportunity to interact with faculty, after taking the feedback sessions. The faculty felt satisfied on the acquisition of new skill for delivering structured feedback to students.
Blood components utilization in hematopoietic stem cell transplantation: Thirteen-year analysis from an apex oncology center of India
Authors: Ojha Shashank , Patle Vijaya , Nagaraju P. , Khattry Navin 
Published: September 2022

Abstract

BACKGROUND:
Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment modality for a range of hematological disorders including malignancies. The increasing volumes of HSCTs impact transfusion services and the requirement of blood products vary depending on the primary disease, type and phase of transplant, and the HSCT donor type.

MATERIALS AND METHODS:
This study analyzed the factors affecting blood component requirements in patients undergoing HSCT. The authors studied the transfusion requirement of packed red blood cells (PRBC) and platelets (PLT) up to 100 days post-transplant among 617 adult patients undergoing HSCT during the study period (2007–2019).

RESULTS:
Requirement of PRBC and PLT was significantly higher (P < 0.05) in allogenic HSCT cases across all three phases of transplant compared to autologous HSCT. Unlike PRBC requirement, the PLT requirement was significantly higher during peri-transplant period for haploidentical HSCT and major ABO-incompatible HSCT group compared to matched related donor HSCT and ABO identical HSCT, respectively. In subset analysis based on diagnosis with leukemia as reference, the multiple myeloma group required less while the anemia group required more PRBC and PLT transfusions. The leukemia group required more PRBC than lymphoma group, while the PLT requirement was vice-versa.

CONCLUSION:
Factors such as allogeneic HSCT, haploidentical donor type, major ABO-incompatible HSCT, and primary diagnosis as leukemia or anemia were the predictors for increased need of blood products. As higher transfusion requirements may translate into increased costs of treatment, a study like this can help in managing blood component inventory and planning treatment costs of a HSCT program.
Knowledge of blood transfusion practices among medical students and residents
Authors: Farah Roula A. , Mitri Aida , El Rahi Hiba , Al Humaidan Hind , Rajab M. Hasan , Kemahli Sabri 
Published: September 2022

Abstract:
A study was conducted to assess and compare the knowledge of blood transfusion practices among medical students and residents in Lebanese and Saudi medical institutions. The online survey consisted of 26 questions: 4 about personal data and experience with transfusion and 22 about knowledge on transfusion practices in the areas of blood donation and donor selection, production and storage of blood components, selection of appropriate blood components, administration of blood components, transfusion reactions, and complications. One hundred and twenty-six students from Saudi Arabia, 84 students from Lebanon, 31 residents from Saudi Arabia, and 23 residents from Lebanon participated in the survey. There were no significant differences between students’ and residents’ levels of knowledge. Similarly, there was no difference between the students’ level of knowledge in the two countries. The correct responses (48% and 46%, for students and residents, respectively) were below the acceptable limit of 60% for both groups. This reflects the need for more vigorous and well-structured education and training for both students and residents.
Is neutropenic fever an obstacle to effective stem cell harvesting?
Authors: Başcı Semih , Bozan Ersin , Yaman Samet , Ulu Bahar Uncu , Bakırtaş Mehmet , Yiğenoğlu Tuğçe Nur , Kılınç Ali , Özcan Nurgül , Dal Mehmet Sinan , Çakar Merih Kızıl , Altuntaş Fevzi 
Published: September 2022

Abstract:

INTRODUCTION:
Autologous stem cell transplantation (ASCT) is a well-established consolidation treatment for many hematologic cancers which delivers prolonged survival. A subset of patients’ adequate stem cell harvest is not achievable with a solitary use of granulocyte colony-stimulating agents (G-CSF). Generally, chemomobilization is employed for patients failing G-CSF and its most feared complication febrile neutropenia (FN).

MATERIALS AND METHODS:
Here, we aimed to investigate the impact of the FN in chemomobilization on apheresis outcomes and engraftment. One hundred and eighty-three patients with the diagnosis of lymphoma or myeloma who underwent chemomobilization between 2015 and 2020 were included in the study.

RESULTS:
Forty-three patients experienced FN. All patients received G-CSF. All myeloma patients were mobilized with 4 g/m2 cyclophosphamide, but it was heterogeneous for lymphoma patients. The precollection blood counts, harvested CD34+ hematopoietic stem cells (HSCs)/kg, apheresis count, and engraftment durations were recorded. Preapheresis leukocyte and platelet were lower in the FN group (P = 0,004 and P = 0,001). Peripheral CD34 HSCs and total harvested CD34 HSCs were similar among groups (P = 0.25 and P = 0.9). More apheresis was needed in the FN group, but it was not significant (P = 0.07). Undergoing ASCT was similar (P = 0.7); however, platelet and neutrophil engraftment durations were slower in the FN group (P = 0.05 and P = 0.001).

CONCLUSION:
Harvesting sufficient CD34+ HSCs from patients with FN is still feasible; however, FN treatment should begin promptly, and further apheresis sessions may be required.
A patient with probable rare blood Group B(A) phenotype
Authors: Chandra Avineesh , Bhasker P. M. Bala , Jain Romesh , Kumar Rakesh , Srivastava Subodh 
Published: September 2022

Abstract
Karl Landsteiner discovered ABO blood group system in the early 20th century, but still, uncertainty remains in immunohematology while detection of ABO subgroups or weaker variants. The presence of weak subgroups in patient samples gives rise to the discrepancy in forward (cell) and reverse (serum) grouping. We here report a case of the B(A) phenotype in a patient who was diagnosed with chronic liver disease with acute pancreatitis, requiring packed red blood cells due to anemia. The blood group discrepancy was resolved using serological testing and adsorption–elution technique. Blood grouping by the tube technique showed 2+ agglutination with anti-A antisera, strong agglutination (4+) with anti-B, anti-AB, and anti-D antisera, 4+ agglutination with A1 cells, and no agglutination with B cells and O cells in serum grouping. Results for both eluate and last wash were negative to all the donor cells used. This report highlights the importance of cell and serum grouping, solving blood group discrepancy, and also in providing crossmatch compatible blood components without delay. This rare phenotype in a patient is the first of its kind reported from India.
Anti-human leukocyte antigen-DPB1 antibody-associated transfusion-related acute lung injury after hematopoietic stem cell infusion
Authors: Balkan Mehmet Can , Okur Fatma Visal , Apak Fatma Burcu Belen , Babayeva Sevil , Ekici Numan Firat , Kuskonmaz Baris , Cetinkaya Duygu Uckan 
Published: September 2022

Abstract:
Although relatively rare among transfusion reactions, transfusion-related acute lung injury (TRALI) is a life-threatening condition, making its prevention, recognition, and early intervention extremely important. Although many etiological factors have been identified, the most common reasons are anti-human leukocyte antigen (anti-HLA) and anti-human neutrophil antigen antibodies that pass from the donor to the recipient during transfusion. TRALI was shown with transfusion of all kinds of blood products, however, it is rarely seen after stem cell infusion. Despite an adult case who developed TRALI after stem cell infusion, there is no pediatric case of TRALI associated with hematopoietic stem cell infusion in the previous literature. Here, we report a pediatric case with TRALI after infusion of the hematopoietic stem cell product from his female donor who has recently given birth 6 months ago. A 9-year-old patient with acquired aplastic anemia was admitted for hematopoietic stem cell transplantation (HSCT) from an ABO and 10/10 HLA compatible 21-year-old sister donor the unmanipulated stem cell product was planned to be infused in 4 h. At the last hour of infusion, the patient had acute hypoxemia, tachycardia, and bilateral pulmonary edema. He was diagnosed with TRALI and completely recovered with supportive therapy in 48 h. The anti-HLA antibody analysis of the donor showed positivity of anti-HLA-DPB1 antibodies. We wanted to emphasize the need for examination of anti-HLA antibodies of the donor and plasma depletion of the product to avoid TRALI in HSCTs from multiparous female donors.
Intraoperative blood loss and blood transfusion requirement among liver transplant recipients: A national single-center experience 2020
Authors: Yusop Mohd Faeiz , Tahir Norlida Mohamad , Azim Sharifah Mai Sarah Syed , Kamaruzaman Ameera Ashyila , Hata Nur Raihan Mohd , Kugaan Arvend , Osman Mohd Fairuz , Yazid Tengku Norita Tengku , Mokhtar Suryati , Omar Haniza , Amir Ahmad Suhaimi 
Published: September 2022

Abstract

BACKGROUND:
Liver transplantation (LT) is a complicated surgical procedure with high risk for massive intraoperative blood loss due to pre-existing coagulopathy, portosystemic shunts with collateral circulations, and splenomegaly. The transfusion service will direct most of their resources toward LT programs with great impact on cost. The purpose of this study was to evaluate single center transfusion strategies and to identify the risk factors associated with the intraoperative blood loss and blood transfusion.

METHODS:
The study includes 18 patients who underwent LT at Hospital Selayang between January 2020 and December 2020. Retrospective analysis of data included preoperative assessment of coagulopathy, intraoperative blood loss, and blood component transfusion.

RESULTS:
The mean age in the study group was 36.4 ± 12.68 years. The mean intraoperative blood loss was 4450 ± 1646 ml requiring 4.17 ± 3.3 packed red blood cell (PRBC) units, 7.56 ± 5.5 platelet units, and 9.50 ± 6.0 fresh-frozen plasma units. The independent risk factor for high blood loss (HBL) group was lower preoperative platelet count and it is statistically significant (P = 0.024). The HBL group is associated with higher usage of PRBC (P = 0.024) and platelet units (P = 0.031) and it is statistically significant. The length of stay (LOS) in intensive care unit (ICU) averaging 8.6 ± 4.95 days, and there is no significant differences comparing the HBL and LBL group (P = 0.552). The mortality <90 days for all recipients was 22.2%.

CONCLUSION:
The preoperative platelet count for is the most important factor associated with HBL in LT procedure. The usage of PRBC and platelet units was statistically higher in the HBL group. Comparing HBL and LBL patients, there is no difference in terms of the LOS in ICU postoperatively. A larger sample size would be needed in view of relatively small sample size.
Induction of thrombotic thrombocytopenic purpura by dengue virus infection in a critical patient: Role of therapeutic plasma exchange
Authors: Biswas Rathindra Nath , Das Sudipta Sekhar , Chakrapani Anupam , Sen Subrata 
Published: September 2022

Abstract
Thrombotic thrombocytopenic purpura (TTP) secondary to dengue fever is a very unusual occurrence. Both conditions are fatal and can result in significant mortality and morbidity if left untreated. In this case, we present a young lady who suffered dengue fever followed by microangiopathic anemia, thrombocytopenic purpura, and altered sensorium. Investigations revealed microangiopathic hemolysis; there was no evidence of disseminated intravascular coagulation. As soon as, we diagnosed the patient as having TTP, we treated her with serial plasma exchange therapy, steroids, and monoclonal antibodies such as rituximab. The patient responded very well to the treatment and completely recovered from neurological symptoms and laboratory parameters also normalized. Hence, timely diagnosis and starting appropriate treatment immediately are key factors for successful outcomes.
Managing blood requirement in a rare P-null phenotype patient during the COVID pandemic in a resource-limited setting
Authors: Shenoy Veena , John Linda , Ganapathi Rema , Janarthanan R. , Udayakumaran Suhas 
Published: September 2022

Abstract
We report the case of a 5-year-old girl with a rare P-null phenotype who presented for a neurosurgical procedure at our center. The case is unique as this patient was one of the two P-null phenotype cases reported in India and we report how we could successfully arrange a rare blood unit for her. As it was challenging to find a donor for her, autologous blood was collected. Despite iron supplementation and erythropoietin injections, her hemoglobin remained low and the required number of autologous units could not be collected. As a consequence of the search initiated with the international and regional rare donor registries, a donor was identified in a remote village in India. Despite the logistic hurdles due to the COVID pandemic, the blood could be transported safely for performing the surgery. A centralized database of rare donors needs to be established to meet such requirements.
Serial intrauterine transfusion for severe fetal anemia due to anti-M alloimmunization
Authors: Kapnosa Hasani Rachmat Dediat , Abdurazak Gatot , Pribadi Adhi 
Published: September 2022

Abstract
Anti-M antibody is one of the causes of severe fetal anemia and intrauterine death despite its relatively low frequency. A G3P2 26-year-old pregnant woman referred to our hospital at 29 weeks gestational age (WGA) with fetal hydrops. Her second pregnancy results in intrauterine fetal death at 35 WGA due to fetal hydrops. From ultrasound exam, we found singleton live fetus with ascites, cardiomegaly, and pericardial effusion. The peak systolic velocity in the fetal middle cerebral artery (PSV-MCA) was 1.44 multiples of the median corresponding to fetal anemia. The patient’s blood group was B RhD+M− N+. A reactive IgG anti-M antibody was detected at 37°C. Fetal hemoglobin (Hb) from the first cordocentesis was 2.2 g/dl and we perform multiple intrauterine transfusions and cesarean section at 34 WGA. The postdelivery Hb level was 10.2 g/dl and infant need three times packed red blood cell transfusions after delivery.
Predictors of posttraumatic growth in oncology patients in a tertiary care hospital in rural background
Authors: SaiLahari Kakarla V. M. , Abhinaya R. V. R. , Mutnuru Venkataramana 
Published: September 2022

Abstract

Background:
Cancer, like other traumatic life events, can generate negative and positive changes in psychological well-being. Negative changes are defined as posttraumatic disorders and positive changes are called posttraumatic growth (PTG). Patients who experience PTG show positive and meaningful changes in their emotional and cognitive life, which has a positive impact on their behavior.

Aim:
The current study aimed to examine the concept of PTG and its social and cultural aspects in cancer patients from rural background arena.

Settings and Design:
This was a cross-sectional observational study.

Materials and Methods:
One hundred and fifty-five cancer-diagnosed patients were included in the study. from a tertiary care hospital, and PTG Inventory (PTGI) was administered to assess the posttrauma growth

Statistical Analysis Used:
Data were analyzed using the SPSS statistics version 23. Descriptive statistics and inferential statistics were performed.

Results:
Cancer patients showed posttrauma growth of 67.95 (standard deviation: 6.65). Of dimensions of PTGI, the highest score was for “relating to others.” Women had higher PTG of 70.46 (3.7) than men. Cervical and breast cancer patients showed higher scores of 71.9 (2.9) and 70.1 (3.5), respectively.

Conclusions:
This study highlighted that women had more PTG and cervical and breast cancer patients had better scores.
Comparing the effect of cup placement between true and false acetabula in total hip arthroplasty in patients with Crowe type 3 dysplastic hip
Authors: Motififard Mehdi , Mir Miran Yazdi Mohammad , Teimouri Mehdi , Hatami Saeed , Rafiee Moslem , Toghyani Arash , Andalib Ali 
Published: September 2022

Background:
Hip dysplasia is one of the most widespread hip disorders. Total hip arthroplasty (THA) is the preferred treatment in patients with cup placement choices in true or false acetabulum. The objective of this research was to compare the effectiveness of the two mentioned procedures.

Materials and Methods:
This study was a randomized, open-label, parallel-group clinical trial, in which 46 patients/51 hips with Crowe type 3 dysplastic hip having THA were assigned to two groups: Group 1 – patients who had cup placement in the true acetabulum and Group 2 – patients who underwent cup placement in the false acetabulum. The variables that were evaluated and analyzed included severity of pain using the visual analog scale (VAS), range of motion (ROM), gait ability, the need for repeated joint replacement, and the Harris Hip Score (HHS).

Results:
Forty-six patients/51 hips were included in the present study. The patients who were evaluated included 30 (65.2%) males and 16 (34.8%) females. The mean age in the population under study was 71.0 ± 10.22, and the mean body mass index of participants was 26.34 ± 2.22 kg/m2. The basic parameters in the two research groups were similar (P > 0.05). There were no significant differences between the two groups in terms of the mean values of VAS and ROM (P > 0.05); however, the mean HHS was significantly higher in the true acetabulum group, 57.90 ± 18.47 versus 48.29 ± 13.80 (P = 0.04).

Conclusion:
The effectiveness of cup placements both in the true and false acetabula was similar in all of the evaluated variables in terms of clinical outcomes except for HHS which was higher in the true acetabulum group. To further support the results of this research, it is recommended that more research be done on a greater population.
Electrophysiological and therapeutic effects of amiodarone in patients with preexcited atrial fibrillation
Authors: Alizadeh Abolfath , Pakroo Maryam , Madadi Shabnam , Keikhavani Ala , Teimouri-Jervekani Zahra , Ghadrdoost Behshid , Emkanjoo Zahra 
Published: September 2022

Background:
Atrial fibrillation (AF) with fast ventricular response over an overt accessory pathway (AP) (preexcited AF) with a short anterograde refractory period is a potentially malignant arrhythmia. This study aimed to evaluate the safety and efficacy of amiodarone for preexcited AF management.

Materials and Methods:
This study enrolled 103 patients with evidence of AP in electrocardiography. Patients with preexcited AF were included in the study. Intravenous amiodarone (300 mg) was infused for 30 min for all patients in the AF rhythm. Electrophysiological parameters were evaluated before amiodarone injection and 2 h after pharmacological or electrical cardioversion.

Results:
Antegrade and retrograde refractory periods of the atrioventricular node (AVN) and AP, as well as antegrade and retrograde Wenckebach points of AVN, were increased significantly after amiodarone infusion. Furthermore, the mean of the shortest preexcited RR interval was increased during the monitoring period. Comparing the preexcited index at the beginning of the study and before cardioversion (2 h later) revealed that the QRS complexes changed to a wider pattern as the preexcitation index changed from 80.61 to 92.26 (P < 0.001). Nineteen (18.4%) patients converted to the sinus rhythm with amiodarone infusion. No ventricular arrhythmia was detected during monitoring.

Conclusion:
Amiodarone could be considered a safe drug in patients with preexcited AF for rate control despite its relatively low efficacy in conversion to the sinus rhythm.