bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dementia research career pipeline: Gender disparities in publication authorships and grant funding outcomes at different career stages
Authors: Andreou Melina , Choi Narshil , Magenti Jorge Gómez , Kohlhaas Susan , Sancho Rosa 
Published: August 2022

Background: Multiple studies have analysed gender disparities in academic research. Here we study the gender composition of the dementia research field at different stages in the career pipeline. Methods: We use various data sources to gain insights about the gender ratio across career stages: conference attendance data as a proxy for the field as a whole; bibliometric data to know who publishes, and who occupies positions of seniority among the listed authors; and Alzheimer’s Research UK’s (ARUK) internal grant funding data to understand who obtains funding. We also analyse the scoring of grant applications based on the gender of the reviewers. Results: Our results confirm that female researchers leave dementia academic research at higher rates than men, before transitioning into senior positions. In 2020, they comprised over 60% of the field, produced 54% of first authorships, but only accounted for 38% of last authorships. Overall, women received 37% of ARUK’s competitive grants, with significant differences between grant schemes awarded for early career researchers (64% female awardees) compared to grant schemes aimed at senior researchers (33% female awardees). Men and women applied for and obtained grants at significantly different rates depending on the career stage at which the grant was aimed. Finally, we also observed that male and female reviewers apply evaluation criteria differently, with men giving better scores than women on average. Conclusions: Our study adds to the evidence that shows that women get published less, receive less funding, and transition into senior academic positions at disproportionally lower rates than men do. We briefly discuss potential reasons why gender disparities arise as researchers progress into senior positions, and offer interventions ARUK can implement in its application and evaluation process to address those disparities.
Peculiarities of neoplasms appeared after total body irradiation and homeostasis parameters in rats
Authors: Snezhkova Elisaveta , Voronina Olena , Zadvornyi Taras , Todor Igor , Lukianova Natalia , Melnyk Victor , Sakhno Laryssa , Bardakhivska Kvitoslava , Chekhun Vasyl , Nikolaev Vladimir 
Published: August 2022

Background: Tissue damage and disruption of metabolic processes as a result of total body irradiation (TBI) could lead to tumorigenesis. Methods: Female rats (25 of 32) were X-irradiated with a 6-Gy dose. On month 12±1 animals were sacrificed. The alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), amylase, lactate dehydrogenase (LDH), Ca 2+, creatinine, glucose, phosphorus, urea, uric acid, total protein, pO2, pCO2, pH, and blood cell count were evaluated in blood. Tumors were examinated histologically. Results: On 12±1 months after TBI, 76% of rats had visually detected tumors, histologically classified as benign fibro adenomas. Metabolic, hematological changes versus healthy control indicated disturbances in the homeostasis system. The blood lactate level was typically higher in animals with tumors than without. The ratio of tumor weight to lactate (or LDH) level in blood was 1±0.5 in the 63% of rats and histological analysis revealed the signs of biphasic hyperplasia of glandular lobes and connective tissue stroma, associated with secretory and proliferative activities in tumor. In animals with high values of this ratio (≥1.5) neoplasms were represented by fibrous and glandular tissues presenting a predominant stromal fibrous component, associated with the prevalence of high proliferation in tumor. While in 20% of tumor bearing rats with the low ratio (<0.5) predominated an epithelial structure with homogeneous basophilic content in the glandular lumens, suggesting the domination of secretory activity in tumor. Conclusions: TBI promoted the alterations of hematological and biochemical parameters of homeostasis in rats and provoked the appearance of benign tumors one year after. The ratio of tumor mass to lactate (or LDH) level in blood seems to be an informative indicator of the histological particularities of tumors, suggesting the prevalence of proliferative or secretory activity, or the balance between them.
The Impact of the Gig Economy on Product Quality Through the Labor Market: Evidence from Ridesharing and Restaurant Quality
Authors: Shin Minkyu , Shin Jiwoong , Ghili Soheil , Kim Jaehwan 
Published: August 2022

This paper seeks to demonstrate the impact of the gig economy on product quality in seemingly unrelated local industries through the labor market. Our empirical context is the quality of service for restaurants in the city of Austin, and we examine how they were impacted by the exogenous exit and reentry of rideshare platforms, Uber and Lyft, because of regulatory changes. We leverage these exogenous shocks and combine them with sentiment-analyzed data from Yelp reviews that capture how customers assess the quality of service at each restaurant. We show that, compared with control cities, customers in Austin become more negative about service quality when Uber and Lyft are present in the city. Additionally, we use rich data on employee turnover and wages to demonstrate that service staff turnover increases in Austin when Uber and Lyft are present compared with the control cities. We also conduct several additional studies and robustness checks that are all congruent with our hypothesis that Uber and Lyft lower the quality of service in Austin restaurants by raising their staff turnover. Together, these results suggest significant ramifications of the gig economy on the broader industries through the labor market. This paper was This paper was accepted by Matt Shum, marketing. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2022.4481 .
Estimating Chalkiness in Endosperm of Typical and Bleached Durum Kernels from Transmission Scanned Images
Authors: Brabec Daniel L. , Pordesimo Lester O. 
Published: August 2022

HighlightsDurum wheat kernels were examined using flatbed scanner in transmission mode.Image processing routines were written to determine the %chalkiness per kernel.The distribution of %chalkiness uniquely described market samples.Abstract. The vitreousness of durum samples is regarded by the worldwide wheat industry as an important quality factor for durum shipments. One issue with grading durum occurs on occasional years of unfavorable harvest conditions which result in the kernel outer bran becoming cloudy. Imaging scanners can use either reflective or transmitted lighting. All scanned images of our durum samples were collected using transmissive lighting. Although, “vitreousness” is the usual term applied to durum samples, for this study, “chalkiness” or the inverse property was featured.Both typical and bleached durum kernels were imaged and analyzed. Bleaching seeds has aided grain inspector to visually evaluate the kernels. With computer imaging analysis of bleached kernels, the magnitude of %chalk was significantly attenuated with bleaching verses typical kernels. Still, discrimination of medium and highly chalky kernels was possible with both the typical and bleached seeds.Seed orientation was a source of measurement variability. Seeds were manually and carefully oriented into two distinctly different positions. At the critical lower levels of detection, crease-down orientation may indicate a 100% vitreous seed with the two-dimension view of the scanner, but then 11 of 25 seeds measured some amount of chalkiness when the seed was turned on its side. Furthermore, for seeds with higher amounts of chalkiness, over half of those seeds measured 30% differences.Several durum market samples were provided by Federal Grain Inspection Service and contained levels of non-vitreous seeds for each of three sub-classes of durum: 80%, 65%, 50% vitreous seed. The samples were imaged and analyzed, and chalkiness distributions were plotted. These plots characterize the %chalk for the three classes of wheat. The imaging methods worked satisfactorily for the high and medium levels %chalk per kernel. But the very-low level of chalkiness per kernel proved to be more challenging and was not consistent. Keywords: Grain inspection, HVAC (hard and vitreous kernels of amber color), Image analysis, Vitreousness.
Gin Saw Thickness Impact on Lint Turnout, Lint Value, and Seed Damage
Authors: Funk Paul A. , Thomas Joseph W. , Yeater Kathleen M. , Kothari Neha , Armijo Carlos B. , Whitelock Derek P. , Wanjura John D. , Delhom Christopher 
Published: August 2022

HighlightsWe compared 0.91 to 1.14 mm thick gin saws by ginning seed cotton from three regions.The gap between the saw and rib was 0.914 mm for the thin saws and 0.800 mm for the thick ones.Response variables were tested using a sequentially reduced (backwards regression) model.Lint “turnout”, lint value, and seed damage did not appear to be significantly different due to saw thickness.Abstract. Over 95% of U.S. cotton post-harvest processing is done using saw gins. Gin saws have long been supplied in three thicknesses. We quantified the effect of saw thickness on lint turnout, lint value, and seed damage, variables that determine producer returns. Saw cylinders stacked with 0.9144 and 1.143 mm (0.036 and 0.045 in.) thick saws, the thinnest and thickest available, were operated in laboratory conditions on three cotton growths (cultivars and production practices) from Mississippi, New Mexico, and Texas in an experiment with five replicates. Fiber quality from samples obtained after lint cleaning was measured using High Volume Instruments (HVI). HVI results were combined with Commodity Credit Corporation Marketing Assistance Loan premium and discount tables to calculate fiber value. Seed damage was estimated after germination using Association of Official Seed Analysts rules. A backwards regression approach in JMP reduced each response variable’s model until only significant controlled and uncontrolled variables remained. Tested variables included: growth and saw thickness and their interaction; processing rate; processing energy; test duration; foreign matter content; moisture content; and ambient humidity and temperature. There was no significant difference in fiber value due to saw thickness. Seed quality differences were insignificant. Differences in lint turnout due to saw thickness also were statistically insignificant. Saw thickness selection may be based on other considerations. Keywords: Cotton gin, Cottonseed, Fiber quality, Gin saw, Saw gin
Assessing the use of a micro-sampling device for measuring blood protein levels in healthy subjects and COVID-19 patients
Authors: Brandsma Joost , Chenoweth Josh G. , Gregory Melissa K. , Krishnan Subramaniam , Blair Paul W. , Striegel Deborah A. , Mehta Rittal , Schully Kevin L. , Dumler J. Stephen , Sikorski CDR Cynthia S. , O’Connor Kelsey , Reichert-Scrivner Susan A. , Paguirigan Carmen M. , Uyehara Catherine F. T. , Ngauy COL Viseth , Myers Christopher A. , Clark Danielle V. 
Published: August 2022

Background
Venous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during outbreaks. Self-collection devices have the potential to shift phlebotomy closer to the point of care, supporting telemedicine strategies and virtual clinical trials. Here we assess a capillary blood micro-sampling device, the Tasso Serum Separator Tube (SST), for measuring blood protein levels in healthy subjects and non-hospitalized COVID-19 patients.

Methods
57 healthy controls and 56 participants with mild/moderate COVID-19 were recruited at two U.S. military healthcare facilities. Healthy controls donated Tasso SST capillary serum, venous plasma and venous serum samples at multiple time points, while COVID-19 patients donated a single Tasso SST serum sample at enrolment. Concentrations of 17 protein inflammatory biomarkers were measured in all biospecimens by Ella multi-analyte immune-assay.

Results
Tasso SST serum protein measurements in healthy control subjects were highly reproducible, but their agreements with matched venous samples varied. Most of the selected proteins, including CRP, Ferritin, IL-6 and PCT, were well-correlated between Tasso SST and venous serum with little sample type bias, but concentrations of D-dimer, IL-1B and IL-1Ra were not. Self-collection at home with delayed sample processing was associated with significant concentrations differences for several analytes compared to supervised, in-clinic collection with rapid processing. Finally, Tasso SST serum protein concentrations were significantly elevated in in non-hospitalized COVID-19 patients compared with healthy controls.

Conclusions
Self-collection of capillary blood with micro-sampling devices provides an attractive alternative to routine phlebotomy. However, concentrations of certain analytes may differ significantly from those in venous samples, and factors including user proficiency, temperature control and time lags between specimen collection and processing need to be considered for their effect on sample quality and reproducibility.
Adverse events following immunization with ChAdOx1 nCoV-19 and BBIBP-CorV vaccine: A comparative study among healthcare professionals of Nepal
Authors: Rayamajhi Sushil , Rafi Md. Abdur , Tripathi Nishant , Dongol Anjana Singh , Pandey Minalma , Rayamajhi Shreejana , Bhandari Subhechchha , Shrestha Pranay , Hasan M. Tasdik , Hossain Md. Golam 
Published: August 2022

Background
Adverse events following immunization (AEFI) against SARS-CoV-2 are common as reported by clinical trials and contemporary evidence. The objective of the present study was to evaluate the local and systemic adverse events following vaccination with ChAdOx1 nCoV-19 and BBIBP-CorV among the healthcare professionals (HCPs) of Nepal.

Methods
This cross-sectional study was conducted among 606 vaccinated HCPs of Kathmandu, Nepal. Data was collected from June 15 to 30, 2021 using a self-administered online survey tool. Multiple binary logistic regression models were used to predict the adverse events according to the vaccine types and doses after adjusting for age, sex, comorbidity and previous SARS-CoV-2 infection.

Results
The mean (SD) age of the participants was 35.6 (13.2) years and 52% of them were female. Almost 59% of participants were vaccinated with two doses and around 54% of total of them took the ChAdOx1 nCoV-19 vaccine. At least one local and systemic adverse event was reported by 54% and 62% of participants after the first dose and 37% and 49% after the second dose of ChAdOx1 nCoV-19 and by 37% and 43% after the first dose and 42% and 36% after the second dose of BBIBP-CorV vaccine respectively. Injection site pain, swelling and tenderness at the injection site were the most frequently reported local AEFI while, fatigue, headache, fever and myalgia were the most frequently reported systemic AEFI. The logistic model demonstrated that the risk of both local and systemic adverse events was higher among the ChAdOx1 nCoV-19 vaccine recipients compared to the BBIBP-CorV vaccine. Almost 10% of individuals reported a post-vaccination SARS-CoV-2 infection and most of them occurred after taking the first dose of vaccine.

Conclusions
Recipients of both the ChAdOx1 nCoV-19 and BBIBP-CorV vaccine among the HCPs of Nepal reported only mild and constitutional symptoms including injection site pain and tenderness, headache, fever, fatigue, etc. after vaccination.
Teoría del Pecking Order para el análisis de la estructura de capital: aplicación en tres sectores de la economía colombiana
Authors: Arévalo Lizarazo Guillermo Alejandro , Zambrano Vargas Sandra Milena , Vásquez García Angel Wilhelm 
Published: August 2022

El propósito de este estudio es verificar si los gerentes de los sectores agropecuario, transporte y almacenamiento, turismo y alimentación de Colombia siguen una jerarquía de preferencias o Pecking Order al definir la estructura de capital de sus empresas. Mediante Bloomberg y EMIS se obtienen estados financieros de 1548 firmas entre 2017 y 2020 y se construyen tres modelos de análisis de datos de panel con efectos fijos, uno por sector. Se evidencia una relación negativa entre rentabilidad y utilidades acumuladas con el nivel de endeudamiento en los sectores agropecuario y turismo y alimentación. También se encuentra que el nivel de endeudamiento del sector turismo y alimentación aumentó con la crisis económica generada por el COVID-19, mientras el del sector agropecuario disminuyó. Se concluye que en estos sí existe una jerarquía de preferencias, no así en el sector transporte y almacenamiento, donde se observa únicamente una relación negativa con la rentabilidad.
Banking Integration in Open, Small Economies of the Pacific Island Countries
Authors: Jayawardena Nirodha , Ranadi Kalolaini , Sharma Parmendra , Cagilaba Seruwaia 
Published: August 2022

Abstract
This is the first study to systematically investigate the extent of financial integration in the small, open Pacific Island Countries (PICs). The study applies Autoregressive Distributed Lag co-integration technique on interest rate spreads and covers Fiji, Papua New Guinea, Vanuatu and Tonga, while controlling for the effects from Australia and the United States for the period 1992 to 2019. In the short run, there is some evidence of regional as well as global integration. In the long run, both regional and global integrations become more pronounced. Explanations, consequences and policy implications are discussed.
Study on pecan seed germination influenced by seed endocarp
Authors: Liu Jia , Xue Tingting , Ren Liying , Cui Mingxia , Jiang Tao , Yang Xutao 
Published: August 2022

Abstract
Nondeep physiological dormancy exists in freshly harvested pecan (Carya illinoinensis) seed, and the endocarp inhibits the seed germination. New methods were tried to detect if “chemical dormancy” or “mechanical dormancy” was caused by the endocarp. The germination of freshly harvested pecan seed with the removal of different parts of the endocarp and the fracture pressure of the endocarp of pecan seed soaked in water at different temperatures were tested. The results showed that (1) there was no significant difference in germination rate between the pecan kernel keeping in touch and out of touch with the same part of the endocarp, (2) whether a part of endocarp was removed to expose the radicle, preventing endocarp from splitting by glue inhibited the radicle elongation significantly, (3) the fracture pressure of the endocarp decreased significantly over water uptake time, and (4) little difference in the fracture pressure of the endocarp between different soaking temperatures. In conclusion, it suggested that (1) the endocarp caused “mechanical dormancy” but “chemical dormancy,” (2) the prevention of radicle elongation was due to the endocarp pressuring the cotyledon rather than the direct physical restriction on the radicle, and (3) the radicle elongation seemed to be able to respond to the suture split and the pressure on the cotyledon.
Correlation between peripheral blood lymphocyte subpopulations and primary systemic lupus erythematosus
Authors: Feng Yan , Li Zhijun , Xie Changhao , Lu Fanglin 
Published: August 2022

Abstract
This study explored the correlation between peripheral blood CD3＋, CD3＋/CD4＋, CD3+/CD8+, CD4＋/CD8＋, CD3−/CD16+ CD56+, and CD3−CD19+ and disease activity of different subtypes of systemic lupus erythematosus (SLE). The percentages of CD3+, CD3+/CD4+, CD3+/CD8+, CD4+/CD8+, CD3−/CD16+ CD56+, and CD3−CD19+ in the peripheral blood of patients (n = 80) classified into lupus nephritis, blood involvement, and joint involvement and SLE in different active stages were detected by flow cytometry. Their correlations with baseline clinical experimental indicators of SLE patients’ SLE disease activity index score (SLEDAI) and complement C3 were analyzed. The results showed that CD3+, CD3+/CD4+, and CD3+/CD8+ at baseline level were negatively correlated with SLEDAI scores. These were positively correlated with C3. In conclusion, T-lymphocyte subpopulations are closely related to SLE activity and can be used as reference indicators to evaluate the SLE activity.
BTBD10 inhibits glioma tumorigenesis by downregulating cyclin D1 and p-Akt
Authors: Liu Yu , Li Sen , Chen Ruoping , Chen Juxiang , Xiao Bo , Lu Yicheng , Liu Jiangang 
Published: August 2022

Abstract
The aim of this study was to investigate the role of BTBD10 in glioma tumorigenesis. The mRNA and protein levels of BTBD10 in 52 glioma tissues and eight normal brain tissues were determined using reverse transcription polymerase chain reaction (RT-PCR) and western blot analysis, respectively. U251 human glioblastoma cells were infected with BTBD10-expressing or control lentiviruses. Cell growth was evaluated using the methyl thiazolyl tetrazolium (MTT) assay. Cell apoptosis and cell cycle distribution were analyzed using flow cytometry. Cyclin D1 and p-Akt levels were determined using western blot analysis. The results showed that BTBD10 mRNA and protein levels were significantly lower in glioma tissues than in normal brain tissues. Additionally, BTBD10 levels were significantly lower in high-grade gliomas than in low-grade tumors. Compared with control cells, U251 cells overexpressing BTBD10 exhibited decreased cell proliferation, increased cell accumulation at the G0/G1 phase, increased cell apoptosis, and decreased levels of cyclin D1 and p-Akt. These findings show that BTBD10 is downregulated in human glioma tissue and that BTBD10 expression negatively correlates with the pathological grade of the tumor. Furthermore, BTBD10 overexpression inhibits proliferation, induces G0/G1 arrest, and promotes apoptosis in human glioblastoma cells by downregulating cyclin D1- and Akt-dependent signaling pathways.
Transient analysis of MTR research reactor during fast and slow loss of flow accident
Authors: Selim Hala Kamal Girgis 
Published: August 2022

Abstract
The main objective for reactor safety is to keep the fuel in a safe condition with adequate safety margins during all operational modes (normal-abnormal and accidental states). To achieve this purpose an accident analysis of different design base accidents (DBAs), one of them is the loss of flow accident (LOFA), is required for assessing reactor safety. In this research, the safety aspects of 22 MW MTR research reactor under steady state and during loss of flow accident is studied. The flow transients considered include fast loss of flow accident (FLOFA) and slow loss of flow accident (SLOFA) modeled with exponential flow decay and time constants of 1 and 25 s, respectively. The analysis is done using PARET, a neutronics-hydrodynamics-heat transfer code. The transients were initiated from a full power with a flow trip point at 85% nominal. The calculated parameters are the temperatures of different components (fuel, clad and coolant) as a function of time for the hot channel. The results indicate that in both accidents the calculated maximum cladding surface temperature for the hottest channel of the reactor core does not exceed the allowable safety limit and the fuel integrity is maintained.