bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors affecting care of elderly patients among nursing staff at the Ho teaching hospital in Ghana: Implications for geriatric care policy in Ghana
Authors: Salia Solomon Mohammed , Adatara Peter , Afaya Agani , Jawula Waliu Salisu , Japiong Milipaak , Wuni Abubakari , Ayanore Martin Amogre , Bangnidong Jacob Erwontaa , Hagan Felix , Sam-Mensah Dorcas , Alhassan Robert Kaba 
Published: June 2022

Introduction
The population of the aged is increasing globally and in Ghana. In 2020, the population aged over 60 years in Ghana was 2,051,903 and this is expected to reach 2.5 million by 2025 and 6.3 million by 2050. Despite the envisaged increase in the number and life expectancy of the older population in Ghana that will require nursing care, there is a paucity of data on nursing staff knowledge and attitudes toward elderly patients in Ghana.

Objectives
This study, therefore, assessed factors affecting the care of elderly patients among nursing staff in a tertiary referral health facility in the Volta region of Ghana.

Methods
The study employed a descriptive cross-sectional design using quantitative data collection approaches. A total of 150 nurses were sampled with a response rate of 95%. Data were analyzed using the Statistical Package for Social Sciences (SPSS) version 23. The analysis included logistic regression to predict factors associated with nurses’ knowledge and attitude in caring for elderly patients, after multicollinearity diagnosis and controlling the effect of confounding variables.

Results
Majority (83.8%) of the nurses demonstrated good knowledge of the aging process, knowledge in the care of the elderly (88.7%), and (84.5%) had a positive caring attitude towards the elderly. Professional education, professional qualification, and knowledge on aged care were significantly associated with nurses’ attitude towards the elderly (p<0.001), (p<0.005), and (p<0.010), respectively. Lack of special wards/facilities emerged as the predominantly perceived barrier to caring for the elderly as per the nurses’ responses.

Conclusion
The majority of nurses demonstrated good knowledge and attitude in the aging process and care of the aged. Lack of special wards/facilities and lack of staff motivation were the leading perceived barriers to rendering care to the elderly. Scaling up gerontological nursing programs and establishing special aged care facilities in Ghana with appropriate policy guidelines and regulations for implementation of care will help improve nurses’ knowledge and caring attitudes toward the care of elderly patients. Likewise, a national geriatric care policy would help consolidate standard geriatric care in Ghana.
Evaluation of Melia azedarach extract-loaded poly (vinyl alcohol)/pectin hydrogel for burn wound healing
Authors: Lee Jun Seung , Sun Kyung Hoon , Park Yongjin 
Published: June 2022

Background
In this study, a hydrogel comprising poly (vinyl alcohol)/pectin (PVA/PET) was prepared by the addition of Melia azedarach extract for epithelial restoration. M. azedarach extract (MAE) contains volatile organic plant-derived compounds with antimicrobial properties. MAE has a variety of physiological properties, including antimicrobial, insecticidal, and anti-inflammatory activity. This study aimed to investigate whether MAE-loaded PVA/PET hydrogels have protective effects against burn wound healing.

Methods and findings
To mix M. azedarach with the gel, nanoparticles containing M. azedarach were prepared using chitosan/maltodextrin as the wall material. A PVA/PET hydrogel containing M. azedarach was developed and its applicability as a wound dressing was evaluated. In the in vitro scratch assay, MAE treatment showed a scratch recovery-promoting effect comparable to that of the positive control TGF-β1. The MAE-PVA/PET hydrogel was found to be non-toxic, and the antibacterial activity of the hydrogel was excellent against both gram-positive and gram-negative bacteria. Furthermore, as the formulated hydrogel demonstrated strong antimicrobial activity, its wound-healing efficacy was investigated in vivo using a rat model.

Conclusion
MAE was found to be effective against burn wounds and to have antimicrobial activity in vitro and in vivo.
Selectivity of Ethanol Extract of Parijoto (Medinilla speciosa) Fruit in HepG2, Widr, 4T1, and Vero cell lines
Authors: Sasikirana Widyandani , Annisaa' Eva , Ekawati Nuraini , Eka Dini Intan Rahmania , Tumbilaka Estevina 
Published: June 2022

Background: Parijoto, one of the melastomaceae family, has been known to have cytotoxic activity in some cancer cell lines, such as HeLa, MCF-7, and T47D. Aims: We aim to know about the selectivity of ethanol extract of Parijoto fruit in cell line HepG2, WiDr, 4T1, and Vero. Cytotoxic was determined by MTT assay. Method: Extract was added in three serial concentration three serial concentrations (125 µg/mL–500 µg/mL), while the positive control doxorubicin gives in 2,5 µg/mL – 20 µg/mL for cancer cell and 40 µg/mL -100 µg/mL for Vero cell. Results: Results showed that ethanol extract of parijoto fruit gave low activity in HepG2 and Vero cell (IC50: 250 µg/mL) and moderate activity in WiDr and 4T1 (IC50: 81,58 µg/mL and 158,72 µg/mL). Conclusion: The highest selectivity index is given in WiDr cell (SI> 3) means that the ethanol extract of parijoto fruit is a promising cytotoxic agent for colorectal cancer therapy.
Insilico Analysis of Codon 131 Polymorphism in FcγRIIA Gene and it is Association with Clinical Symptoms Persistence of Dengue Patients
Authors: Nugraheni Enny , Ramadhani Dwi , Sariyanti Mardhatillah , Febrianti Ety 
Published: June 2022

Background. Dengue Hemorrhagic Fever (DHF) is infection caused by Dengue Virus. Failure of vascularization is a main symptom of Dengue Hemorrhagic Fever inducing mediator secretion by an immune cell. FcgRIIA and CCL2 have a significant role in dengue pathogenesis and possibility in having a chance to cause dengue with a worse manifestation. Objective. Analysis of bio-informatic structure, function and expression of FcgRIIA gene. Methods. Insilico analysis used NCBI database to find position and sequences. Analysis mutant use SNO and OMIM. Protein prediction withUniprot. Result. FcgRIIA human with access number of NM_001136219 by a length of 2429 bp has its full name as Fc Fragment of IgG receptor IIa, located in 1q23.3 chromosom. analyzed mutation was rs1801274 with type of missense protein residue function experiencing a change from Histidin (H) turning into Arginin (R) with allele of wild-type A and becoming G amino acid position of 166. there was structural difference of FcgRIIA gene in wild type and mutant. Conclusion. Gene FcγRIIA is a play a role of pathogenesis of dengue infection. Mutation in FcγRIIA have polymorfisme at Dengue Hemorrage Fever
THE EFFECT OF BEETROOT JUICE (Beta vulgaris L.) ON THE CONCENTRATION OF SPERMATOZOA IN WISTAR RATS EXPOSED TO MOSQUITO COIL SMOKE
Authors: Sapto Dean Pandu Eko , Hermawati Donna , Ariani RR. Mahayu Dewi , Putra Farmaditya Eka 
Published: June 2022

Background: Mosquito coil smoke contains Allethrin that can increase the free radical effect. This process may result in the damage of the cell membranes that triggered by oxidative stress. Oxidative stress can affect spermatogenesis and decreasing the quality of spermatozoa, including the spermatozoa concentration. Beetroot contain flavonoid as an antioxidant which can counteract the free radicals in the body.Purpose: To identify the effect of beetroot juice in the spermatozoa concentration of Wistar rats that exposed by mosquito coil smoke.Method: This study used Post Test Only control group design. The samples were 28 male Wistar rats that divided into 4 groups. The Control Group(-) was a group without treatment. The Control Group(+) was only exposed by mosquito coil smoke. Group P1 was exposed by mosquito coil smoke and given 8 ml of beetroot juice. P2 group was exposed by mosquito coil smoke and given 16 ml of beetroot juice. For 56 days, on the 57th day all rats were terminated and spermatozoa concentrations were examined.Results: The average concentration of spermatozoa was: Group K(-)=20,00; Group K(+)=8,00; P1 group=12,40; P2 group=17,20. One Way ANOVA test found there were significant differences among the five treatment groups. Post-Hoc test found there were significant differences among K(-) with K(+), K(-) with P1, K(-) with P2, K(+) with P1, K(+) with P2 and P1 with P2.Conclusion: Beetroot juice administration increasing the spermatozoa concentration of male wistar rats that exposed by cigarette smoke.Keywords: Mosquito coil smoke, beetroot juice, spermatozoa concentration
POTENTIAL USE OF VIRTUAL REALITY IN OVERCOMING NEEDLE PHOBIA IN COVID-19 VACCINATION
Authors: Herlambang Penggalih Mahardika , Wiyono Nanang , Gunawan Hendry , Budiyanti Rani Tiyas 
Published: June 2022

Background: Vaccination is very important because it can help prevent diseases that can be prevented by immunization (PD3I) such as polio, tetanus, diphtheria, measles, mumps, and rubella. During the Coronavirus Disease -19 (COVID-19) pandemic, the role of vaccination is very crucial, especially to reach herd immunity. However, there are many problems related to the implementation of vaccination, including needle phobia, which is a phobia of needles because it is considered painful. Virtual reality is a technology that develops in the form of a virtual image that can be used in vaccination services. This study aims to determine the potency of virtual reality to solve the needle phobia in vaccination services.Methods: The method used in this study is a literature review with sources from journals in the Scopus, ProQuest, and ScienceDirect database that was published in 2000 until 2020, and also books and articles with the keywords "virtual reality" "AND" "immunization," virtual reality " AND " vaccination " , "Needle phobia" "AND" "vaccination". This research was conducted from January to February 2021.Results: Based on the results obtained, virtual reality can be used in vaccination services, especially in the treatment of needle phobia. Virtual reality can become a distraction so that the patient will be distracted from fear and can lower the pain threshold. In addition, virtual reality can also be used as a means of education about immunization.Conclusion: Product development and clinical research need to be developed to assess the use of virtual reality in vaccination services during the COVID-19 pandemic. The use of virtual reality for other medical procedures that use needles can also be further investigated
Correlation between Body Mass Index, Muscle Mass, and Muscle Explosive Power in First-Year Medical Students of Diponegoro University
Authors: Arum sari Devi Wahyu , Ahmadi Hafizhil Uzhma Al , Jordan Timothy , Puruhito Buwono , Basyar Edwin , Indraswari Darmawati Ayu 
Published: June 2022

Abstract Background: Muscle explosive power as a component of physical fitness is an important factor that supports athletic performance in most sports. jump height and vertical jump performance in assessing explosive muscle power are influenced by various factors, including physiological, biomechanical, and anthropometric factors. Body mass index, muscle mass, and fat mass are important anthropometric factors in supporting jumping performance.Objective: To analyze the relationship between body mass index and muscle mass with legs muscle explosive power in first-year medical students of Diponegoro University.Methods: This study is an observational analytic study with a cross-sectional design. The subjects consist of 60 males and 108 females in first-year medical students of Diponegoro University who met the criteria. Body mass index and muscle mass were measured by Omron bioelectrical impedance analyzer, and muscle explosive power was measured by vertical jump test. Data were analyzed with the Kolmogorov Smirnov normality test and Spearman correlation test.Results: The average value of body mass index was 21.760±2.7734, muscle mass was 29.468±4.3283, and muscle explosive power was 29.468±4.3283. Muscle mass was positively correlated with legs muscle explosive power (p=0.00, R= 0.583) and negatively correlated between body mass index and legs muscle explosive power but it was not statistically significant (p=0.823 dan R=- 0.017) in first-year medical students of Diponegoro University.Conclusion: Muscle mass was positively correlated with legs muscle explosive power and body mass index showed no significant correlation with muscle explosive power. Keywords: body mass index, muscle explosive power, muscle mass, vertical jump test
THE EFFECT OF ROSELLA DRIED CALYX INFUSION (HIBISCUS SABDARIFFA) IN LOWERING LDL CHOLESTEROL SERUM LEVEL ON CIGARETTE SMOKE EXPOSED MALE SPRAGUE DAWLEY RATS
Authors: Rolanda Gabriela , Batubara Lusiana , Saraswati Indah , DK Kusmiyati Tjahjono 
Published: June 2022

Background: Cigarettes increase cardiovascular risks by modifying lipid profiles through oxidation, alternating lipoprotein composition, and fat metabolizing enzyme activity. Vascular dysfunction can primarily identified by LDL cholesterol composition shift, one of atherosclerosis predictor. Rosella is a multifunctional herb that widely used as a pleasant tea. Aside from its rich components, anthocyanin, pectin, PCA and hibiscus acid are playing the role keys in lowering LDL cholesterol through lipid metabolism enzyme activity modification. Rosella is easy to find, relatively cheap, tasteful and also categorized as food-grade FDA approved.Aim: To investigate the effect of rosella infusion in decreasing LDL cholesterol serum on cigarettes exposed male Sprague dawley rat.Methods: This study is a true experimental study design with post-test only controlled group design. After 7 days of adaptation, a total of 30 male Sprague dawley rats were randomly divided into 5 groups (n=6 per group); KN received no special treatment; KP exposed to 4 rods of cigarette smoke/day; experimental groups (P1, P2, P3) exposed to 4 rods of cigarette smoke/day and rosella dried calyx infusion with 250, 500 and 1000 mg/kg respectively for 30 consecutive days. LDL cholesterol levels are measured using the CHOD-PAP method. Collected data were analyzed statistically using One Way ANOVA Test.Results: There is a significant difference between all experimental groups (p=0,00) in the post-hoc test.Conclusion: These lines of evidence suggest that rosella infusion significantly decreases LDL Cholesterol serum level in cigarettes exposed Sprague dawley rats in a dose-dependent manner.Keywords: Cigarettes smoke, LDL cholesterol, Rosella calyx infusion
THE EFFECT OF 0.12% CHLORHEXIDINE DIGLUCONATE AND 0.1% CHLORINE DIOXIDE ON DISCOLORATION OF NANOFILLED COMPOSITE RESIN
Authors: Shabika Shabika , Wibowo Gustantyo Wahyu , Purnawati Ratna Damma , Nosartika Isniya 
Published: June 2022

ABSTRAK Background: Composite resins are able to generate the color of dental restorative materials based on the original teeth's color. Nanofilled composite resins have compressive strength, good polishing, and color stability compared to other types of composite resins. Color changes may occur due to intrinsic and extrinsic factor example mouthwash. Mouthwash that is commonly used is chlorhexidine. The use of chlorhexidine mouthwash continuously may stain the composite resins. Mouthwash that has a good anti-plaque other than chlorhexidine is chlorine dioxide which has a clear color and does not cause changes in taste on the tongue.Aim: To determine the effect of 0.12% chlorhexidine digluconate mouthwash and 0.1% chlorine dioxide mouthwash to the discoloration of nanofilled composite resins. Methods: This study is an experimental study with a pre-test and post-test control group design. Samples are nanofilledcomposite resins made into discs in total of 27 and divided into three groups with different treatments, soaked with 0.12% chlorhexidine digluconate mouthwash, 0.1% chlorine dioxide mouthwash, and sterile distilled water. Each group was soaked for 24 hours and tested for staining using chromameter.Result: ANOVA test showed the significant difference between group, that the greatest color change is the one soaked with 0.12% chlorhexidine digluconate mouthwash compared to 0.1% chlorine dioxide mouthwashConclusions: The use of 0.1% chlorine dioxide mouthwash does not cause discoloration as much as 0.12% chlorhexidine digluconate mouthwash.Keywords: Chlorhexidine digluconate, Chlorine dioxide, nanofilled composite resin, discoloration
A CASE STUDY OF A 54-YEAR-OLD MAN WITH NYHA CLASS III, STAGE 2 HYPERTENSION, AND TYPE II DIABETES MELLITUS
Authors: Ingan Ergani Nopiane Rospita , Helena Friska Anggraini 
Published: June 2022

Background: Heart failure is when the heart cannot pump enough blood to fulfill the body's needs. This disease is dangerous and can lead to death. The most common risk factors are hypertension, diabetes mellitus, and metabolic syndrome.Case Presentation: A 54-year-old man complained of shortness of breath for the last one month, which worsened during light activities and decreased when he was in a semi-sitting position. The patient had a history of hypertension and type-II diabetes mellitus for the last five years. On physical examination, the patient's blood pressure was 140/100 mmHg, respiratory rate was 25 bpm. There were paroxysmal nocturnal dyspnea, orthopnea, rales on both basal lung fields, dyspnea on exertion, ankle edema, a pansystolic murmur heard in the apex, ascites and ankle edema. Blood laboratory examination showed HbA1c 6%, chest X-ray and ECG showed cardiomegaly.Conclusion: The patient was diagnosed with NYHA Class III Heart Failure with stage 2 hypertension and type-2 diabetes mellitus and was treated with fluids, diuretics, ACE inhibitors, beta-blockers, low salt diet, restriction of fluid intake, and oral antidiabetics.
Relationship Between Frequency Of Tension Type Headache (TTH) In Epilepsy With Cognitive Function
Authors: Patlika Diah , Suryawati Herlina , Widiastuti M.I. , Kustiowati Endang , Muhartomo Hexanto , Wati Arinta Puspita 
Published: June 2022

Background : Epilepsy is a chronic disease that increases the risk of interictal headaches, one of which is tension type headache (TTH). TTH in epilepsy is triggered by recurrent neurogenic inflammation and central sensitization leading to pericranial tenderness. Recurrent neurogenic inflammation can affect cognitive function. The frequency of TTH in epilepsy is thought to be related to cognitive function score.Objective : Analyzing the relationship between the category of TTH frequency, onset of epilepsy, seizure frequency, age and education with cognitive score.Methods : Our study is an analytic observational study with a cross sectional design that took place from April to September 2021. The subjects of the study were epilepsy patients suffering from TTH at Dr. Kariadi Hospital, Semarang who met the inclusion and exclusion criteria. Patients’s data was obtained by filling out a questionnaire form. Assessment of the category of TTH frequency used ICHD-3 beta 2013 criteria. Assessment of cognitive function used the MoCA-Ina score. Data was analyze with Spearman correlation test, the results were significant if the p value <0.05.Results : Forty one epilepsy patients consist of 14 infrequent episodic TTH, 14 frequent episodic TTH and 13 chronic TTH. There was significant relationship between the MoCA-Ina score and the TTH frequency category (r=0,362; p=0,02), and education level (r=0,493; p=0,001). There was a weak relationship between the MoCA-Ina score and the onset of epilepsy or seizure frequency, while there was no relationship with age.Conclusion : There was a moderate relationship between the TTH frequency in epilepsy with cognitive function. Keywords : epilepsy, tension type headache (TTH), Montreal Cognitive Assesment - Indonesian version (MoCA-Ina)
Correlation between Interleukin 10 Serum Levels and Severity of Peripheral Neuropathy in Multibacillary Leprosy Patients a Research Article
Authors: Reliyana Fajar Sekti , Muhartomo Hexanto , Kustiowati Endang , Rahmat Sugiyanto Yosep Ferdinand , Retnaningsih Retnaningsih , Puspita Wati Arinta , Ardhini Rahmi , Kurnianto Aditya 
Published: June 2022

ABSTRACT Background of the ResearchLeprosy is a chronic infectious peripheral neuropathy caused by Mycobacterium leprae. Clinical presentations of leprosy neuropathy are obtained when the nerve damage is more than 30% of peripheral nerve fibers. The anti-inflammatory property of interleukin 10 is supposed to protect tissue from the damage caused by proinflammatory cytokines. Instead, it causes extensive nerve damage due to suppression of the cellular immune system, failure of forming granuloma to limit the growth of Mycobacterium leprae. As a result, it multiplies and spreads. Purpose of the ResearchThe purpose of the research is to analyze the correlation between interleukin levels 10 serum and the severity of peripheral neuropathy. Methods of the ResearchThe method used is cross-sectional research on 30 subjects with multibacillary leprosy aged 18-65 at the Neurology Department of Kelet Hospital Jepara from September to October 2021. The questionnaire was used to collect data of the patients. Interleukin level 10 serum evaluation is assessed by examining blood serum. Data analysis used Spearman Correlation Test. The significant result occurs if it is p<0.05. Research resultPatients with multibacillary leprosy are mostly men (73.3%). There is also a strong significant correlation between interleukin 10 levels and the severity of peripheral neuropathy (p<0.001) with rho (0.7) ConclusionThere is a strong and significant correlation between serum interleukin 10 levels and the severity of peripheral neuropathy in multibacillary leprosy Keywords: multibacillary leprosy, interleukin 10, peripheral neuropathy
Immune Response and Prognosis of Chronic Kidney Disease Patients Undergoing Hemodialysis Against COVID-19: A Systematic Review
Authors: Hanifa Nurul , Muzasti Riri Andri 
Published: June 2022

Background: Chronic kidney disease (CKD) patients are characterized by immune response dysfunction which increased susceptibility to infections. CKD is one of the Coronavirus disease-2019 (COVID-19) comorbidity that generally has a poor clinical outcome and patients undergoing hemodialysis had a 50% hospitalization rate and 20%-30% mortality rate. Seroconversion after confirmation of COVID-19 infection is close to 100% in the dialysis population, but the durability of the immune response and the extent as a protection against infection remains unclear. This study aimed to determine the immune response and prognosis of CKD patients undergoing hemodialysis against COVID-19.Objective: To determine immune response and prognosis of CKD patients undergoing hemodialysis against COVID-19.Methods: This is a systematic review study that used literature sourced from online journal databases on Google Scholar, PubMed, Cochrane, and Clinical Key sites. Literature that has passed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) staging and the journal quality review based on the Newcastle-Ottawa Scale (NOS) assessment is then synthesized qualitatively and presented systematically.Results: Based on the data analysis, there were positive immune responses in 460 of 735 (62.6%) CKD patients undergoing hemodialysis against COVID-19 and a higher mortality rate (10.5%) than the control group (6.9%).Conclusion: The immune response and prognosis of CKD patients undergoing hemodialysis against COVID-19 were worse than the control group. Therefore, COVID-19 vaccination should be prioritized in CKD patients undergoing hemodialysis.