bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTASI SUPERVISI AKADEMIK UNTUK MENINGKATKAN KINERJA GURU PADA MASA PANDEMI COVID-19
Authors: Mukroni Siti 
Published: January 2022

Berdasarkan pengamatan sementara di SMA Negeri 2 Sentajo Raya Kabupaten Kuantan Singingi, ditemukan fenomena antara lain; Adanya sebagian guru yang belum melengkapi perangkat pembelajarannya, seperti Rencana Pelaksanaan Pembelajaran (RPP) dan sebagainya. Adanya sebagian guru yang tidak menjalankan tugas sesuai dengan ketentuan-ketentuan yang telah ditentukan, hal ini terlihat adanya guru yang meninggalkan sekolah ketika jam mengajar. Kurangnya inisiatif guru dalam mengembangkan model atau metode pembelajaran yang lebih menarik bagi anak. Kurangnya kreatifitas guru dalam penyediaan media dan sumber belajar yang bervariasi, termasuk menggunakan aplikasi pembelajaran online. Jenis penelitian ini adalah Penelitian Tindakan Sekolah (PTS) berlokasi di SMA Negeri 2 Sentajo Raya Kabupaten Kuantan Singingi, yang ditujukan pada guru-guru. Adapun alasan utamanya adalah dari hasil pengamatan dan informasi dari guru, bahwa kinerja guru pada masa pandemi tergolong kurang. Tempat penelitian adalah di SMA Negeri 2 Sentajo Raya Kabupaten Kuantan Singingi. Waktu penelitian ini dilaksanakan pada bulan maret 2021. Jumlah sampel yang ditetapkan dalam penelitian ini adalah 26 orang guru. Dari uraian pengolahan data dan pembahasan didapatkan kesimpulan bahwa kinerja guru didapatkan pada siklus I sebesar 60% dengan kategori baik dan pada siklus II meningkat menjadi 91% dengan kategori baik. Artinya bahwa Kegiatan Supervisi dapat Meningkatkan Kinerja Guru di SMA Negeri 2 Sentajo Raya Kabupaten Kuantan Singingi dikatakan berhasil.
Evaluasi Pelaksanaan Edukasi Kesiapan Belajar Mandiri (EKBM) Pada Mahasiswa Pembelajar Jarak Jauh Di Universitas Terbuka
Authors: Purwantiningsih Ary 
Published: January 2022

Penelitian ini merupakan penelitian kualitatif tentang evaluasi pelaksanaan Edukasi Kesiapan Belajar Mandiri pada mahasiswa pembelajar jarak jauh di UT. Penelitian ini bertujuan untuk mengetahui:1. pelaksanaan EKBM di UPBJJ-UT, 2. faktor-faktor yang mempengaruhi pelaksanaan Edukasi Kesiapan Belajar Mandiri. 3. Kendala yang ditemui dalam pelaksanaan Edukasi Kesiapan Belajar Mandiri dan solusi yang harus dilakukan untuk mengatasi kendala tersebut, 4. Persepsi tentang dampak yang dirasakan oleh mahasiswa terhadap pelaksanaan Edukasi Kesiapan Belajar Mandiri. Teknik pengumpulan data menggunakan Forum Group Discussion (FGD) dengan mahasiswa dan petugas UPBJJ-UT. Hasil penelitian menunjukkan bahwa pelaksanaan EKBM pada umumnya berjalan dengan lancar walaupun ada beberapa faktor yang mempengaruhi pelaksanaan EKBM yaitu dari sudut instruktur sendiri, motivasi yang rendah, kedisiplinan, waktu, lingkungan, kebiasaan dan usia. Akan tetapi semua itu bisa diatasi.Persepsi mahasiswa tentang dampak pelaksanaan EKBM sangat bagus. Pelatihan EKBM perlu untuk dipertahankan karena mahasiswa sangat terbantu dalam mempelajari modul, mereka menjadi tahu cara belajar yang lebih baik.
БИОДЕМОГРАФИЧЕСКИЕ АСПЕКТЫ АДАПТАЦИИ КЕРЧЕНСКОЙ ДИАСПОРЫ ИТАЛЬЯНЦЕВ
Authors: Дзини С. , Спицына Н.Х. , Хохлов Н.В. 
Published: January 2022

После краткого введения об истории возникновения и формирования диаспоры «итальянцев Крыма», в статье описаны результаты комплексного социального и биодемографического анализа, проведенного среди современных представителей изучаемой группы, на основании разработанной нами программы анкетирования.
Представленные данные, собранные в ходе экспедиций в Крым и в Италию в 2016–2019 гг., обнародуются впервые. Современные итальянцы Крыма являются потомками итальянских мигрантов, прибывших в черноморско-азовский регион, в частности на Крымский полуостров c Апеннинского полуострова, разными миграционными потоками, с конца XVIII века и до начала XX века.
Comprehensive Analysis of Hub Genes Associated With Competing Endogenous RNA Networks in Stroke Using Bioinformatics Analysis
Authors: Chen Xiuqi , Wu Danhong 
Published: January 2022

Background: Acute ischemic stroke (AIS) is the second leading cause of death and the third leading cause of disability worldwide. Long noncoding RNAs (lncRNAs) are promising biomarkers for the early diagnosis of AIS and closely participate in the mechanism of stroke onset. However, studies focusing on lncRNAs functioning as microRNA (miRNA) sponges to regulate the mRNA expression are rare and superficial.Methods: In this study, we systematically analyzed the expression profiles of lncRNA, mRNA (GSE58294), and miRNA (GSE110993) from the GEO database. Gene ontology (GO) analysis was performed to reveal the functions of differentially expressed genes (DEGs), and we used weighted gene co-expression network analysis (WGCNA) to investigate the relationships between clinical features and expression profiles and the co-expression of miRNA and lncRNA. Finally, we constructed a lncRNA–miRNA–mRNA competing endogenous RNA (ceRNA) network with selected DEGs using bioinformatics methods and obtained ROC curves to assess the diagnostic efficacy of differentially expressed lncRNAs (DElncRNAs) and differentially expressed mRNAs (DEmRNAs) in our network. The GSE22255 dataset was used to confirm the diagnostic value of candidate genes.Results: In total, 199 DElncRNAs, 2068 DEmRNAs, and 96 differentially expressed miRNAs were detected. The GO analysis revealed that DEmRNAs primarily participate in neutrophil activation, neutrophil degranulation, vacuolar transport, and lysosomal transport. WGCNA screened out 16 lncRNAs and 195 mRNAs from DEGs, and only eight DElncRNAs maintained an area under the curve higher than 0.9. By investigating the relationships between lncRNAs and mRNAs, a ceRNA network containing three lncRNAs, three miRNAs, and seven mRNAs was constructed. GSE22255 confirmed that RP1-193H18.2 is more advantageous for diagnosing stroke, whereas no mRNA showed realistic diagnostic efficacy.Conclusion: The ceRNA network may broaden our understanding of AIS pathology, and the candidate lncRNA from the ceRNA network is assumed to be a promising therapeutic target and diagnostic biomarker for AIS.
Systematic Evaluation of HLA-G 3’Untranslated Region Variants in Locally Advanced, Non-Metastatic Breast Cancer Patients: UTR-1, 2 or UTR-4 are Predictors for Therapy and Disease Outcome
Authors: Rebmann Vera , Schwich Esther , Michita Rafael Tomoya , Grüntkemeier Lisa , Bittner Ann-Kathrin , Rohn Hana , Horn Peter A. , Hoffmann Oliver , Kimmig Rainer , Kasimir-Bauer Sabine 
Published: January 2022

Despite major improvements in diagnostics and therapy in early as well as in locally advanced breast cancer (LABC), metastatic relapse occurs in about 20% of patients, often explained by early micro-metastatic spread into bone marrow by disseminated tumor cells (DTC). Although neoadjuvant chemotherapy (NACT) has been a successful tool to improve overall survival (OS), there is growing evidence that various environmental factors like the non-classical human leukocyte antigen-G (HLA-G) promotes cancer invasiveness and metastatic progression. HLA-G expression is associated with regulatory elements targeting certain single-nucleotide polymorphisms (SNP) in the HLA-G 3’ untranslated region (UTR), which arrange as haplotypes. Here, we systematically evaluated the impact of HLA-G 3’UTR polymorphisms on disease status, on the presence of DTC, on soluble HLA-G levels, and on therapy and disease outcome in non-metastatic LABC patients. Although haplotype frequencies were similar in patients (n = 142) and controls (n = 204), univariate analysis revealed that the UTR-7 haplotype was related to patients with low tumor burden, whereas UTR-4 was associated with tumor sizes &gt;T1. Furthermore, UTR-4 was associated with the presence of DTC, but UTR-3 and UTR-7 were related to absence of DTC. Additionally, increased levels of soluble HLA-G molecules were found in patients carrying UTR-7. Regarding therapy and disease outcome, univariate and multivariate analysis highlighted UTR-1 or UTR-2 as a prognostic parameter indicative for a beneficial course of disease in terms of complete response towards NACT or progression-free survival (PFS). At variance, UTR-4 was an independent risk factor for a reduced OS besides already known parameters. Taken into account the most common HLA-G 3’UTR haplotypes (UTR-1–UTR-7, UTR-18), deduction of the UTR-1/2/4 haplotypes to specific SNPs revealed that the +3003C variant, unique for UTR-4, seemed to favor a detrimental disease outcome, while the +3187G and +3196G variants, unique for UTR-1 or UTR-2, were prognostic parameters for a beneficial course of disease. In conclusion, these data suggest that the HLA-G 3’UTR variants +3003C, +3187G, and +3196G are promising candidates for the prediction of therapy and disease outcome in LABC patients.
Effect of the Addition of 4 wt% Zr to BCC Solid Solution Ti52V12Cr36 at Melting/Milling on Hydrogen Sorption Properties
Authors: Kamble Amol , Sharma Pratibha , Huot Jacques 
Published: January 2022

The addition of 4 wt% Zr to Ti52V12Cr36 alloy was carried out in two different ways: arc-melting or ball-milling. The cast alloy showed rapid hydrogen absorption up to 3.6 wt% of hydrogen capacity within 15 min. Ball milling this sample worsened the kinetics, and no hydrogen absorption was registered when milling was carried out for 30 or 60 min. When zirconium is added by ball-milling, the kinetic is slower than that when addition is by arc-melting. This is due to the fact that when added by milling, zirconium does not form a ternary phase with Ti, V, and Cr but instead is just dispersed on the particles’ surface.
Oral Health-Related Quality of Life in Patients With Chronic Respiratory Diseases—Results of a Systematic Review
Authors: Li Simin , Ning Wanchen , Wang Wei , Ziebolz Dirk , Acharya Aneesha , Schmalz Gerhard , Zhao Jianjiang , Huang Shaohong , Xiao Hui 
Published: January 2022

Background: This systematic review evaluates the oral health-related quality of life (OHRQoL) of patients with chronic respiratory diseases.Methods: A systematic literature search was performed based on the PubMed, Medline, Web of Science, and Scopus, using the search terms: “oral health-related quality of life” and “respiratory disease” or “lung” and “oral health-related quality of life.” Full-text articles published until June 30, 2021 and reporting any OHRQoL measurement in children or adults with a chronic respiratory disease or condition were included and analyzed qualitatively.Results: A total of seven out of 44 studies were included, of which four studies examined adults and three studies investigated children. The respective diseases were chronic obstructive pulmonary disease (COPD) (n = 2), sleep apnea (n = 2), severe asthma (n = 1), cystic fibrosis (n = 1), and lung transplantation (n = 1). Four studies confirmed a worse OHRQoL in the respiratory diseased group compared to healthy controls. The overall OHRQoL was reduced in the included studies. Oral health, health-related quality of life, and disease-related parameters were rarely examined with regard to OHRQoL.Conclusion: Patients with chronic respiratory diseases show a reduced OHRQoL. Oral health should be fostered in these individuals to support their OHRQoL.
Relationship Between Baroreflex and Cerebral Autoregulation in Patients With Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage
Authors: Uryga Agnieszka , Nasr Nathalie , Kasprowicz Magdalena , Budohoski Karol , Sykora Marek , Smielewski Peter , Burzyńska Małgorzata , Czosnyka Marek 
Published: January 2022

Introduction: Common consequences following aneurysmal subarachnoid hemorrhage (aSAH) are cerebral vasospasm (CV), impaired cerebral autoregulation (CA), and disturbance in the autonomic nervous system, as indicated by lower baroreflex sensitivity (BRS). The compensatory interaction between BRS and CA has been shown in healthy volunteers and stable pathological conditions such as carotid atherosclerosis. The aim of this study was to investigate whether the inverse correlation between BRS and CA would be lost in patients after aSAH during vasospasm. A secondary objective was to analyze the time-trend of BRS after aSAH.Materials and Methods: Retrospective analysis of prospectively collected data was performed at the Neuro-Critical Care Unit of Addenbrooke's Hospital (Cambridge, UK) between June 2010 and January 2012. The cerebral blood flow velocity (CBFV) was measured in the middle cerebral artery using transcranial Doppler ultrasonography (TCD). The arterial blood pressure (ABP) was monitored invasively through an arterial line. CA was quantified by the correlation coefficient (Mxa) between slow oscillations in ABP and CBFV. BRS was calculated using the sequential cross-correlation method using the ABP signal.Results: A total of 73 patients with aSAH were included. The age [median (lower-upper quartile)] was 58 (50–67). WFNS scale was 2 (1–4) and the modified Fisher scale was 3 (1–3). In the total group, 31 patients (42%) had a CV and 42 (58%) had no CV. ABP and CBFV were higher in patients with CV during vasospasm compared to patients without CV (p = 0.001 and p &lt; 0.001). There was no significant correlation between Mxa and BRS in patients with CV, neither during nor before vasospasm. In patients without CV, a significant, although moderate correlation was found between BRS and Mxa (rS = 0.31; p = 0.040), with higher BRS being associated with worse CA. Multiple linear regression analysis showed a significant worsening of BRS after aSAH in patients with CV (Rp = −0.42; p &lt; 0.001).Conclusions: Inverse compensatory correlation between BRS and CA was lost in patients who developed CV after aSAH, both before and during vasospasm. The impact of these findings on the prognosis of aSAH should be investigated in larger studies.
The Role of Microtubule Associated Serine/Threonine Kinase 3 Variants in Neurodevelopmental Diseases: Genotype-Phenotype Association
Authors: Shu Li , Xiao Neng , Qin Jiong , Tian Qi , Zhang Yanghui , Li Haoxian , Liu Jing , Li Qinrui , Gu Weiyue , Wang Pengchao , Wang Hua , Mao Xiao 
Published: January 2022

Objective: To prove microtubule associated serine/threonine kinase 3 (MAST3) gene is associated with neurodevelopmental diseases (NDD) and the genotype-phenotype correlation.Methods: Trio exome sequencing (trio ES) was performed on four NDD trios. Bioinformatic analysis was conducted based on large-scale genome sequencing data and human brain transcriptomic data. Further in vivo zebrafish studies were performed.Results: In our study, we identified four de novo MAST3 variants (NM_015016.1: c.302C &gt; T:p.Ser101Phe; c.311C &gt; T:p.Ser104Leu; c.1543G &gt; A:p.Gly515Ser; and c.1547T &gt; C:p.Leu516Pro) in four patients with developmental and epileptic encephalopathy (DEE) separately. Clinical heterogeneities were observed in patients carrying variants in domain of unknown function (DUF) and serine-threonine kinase (STK) domain separately. Using the published large-scale exome sequencing data, higher CADD scores of missense variants in DUF domain were found in NDD cohort compared with gnomAD database. In addition, we obtained an excess of missense variants in DUF domain when compared autistic spectrum disorder (ASD) cohort with gnomAD database, similarly an excess of missense variants in STK domain when compared DEE cohort with gnomAD database. Based on Brainspan datasets, we showed that MAST3 expression was significantly upregulated in ASD and DEE-related brain regions and was functionally linked with DEE genes. In zebrafish model, abnormal morphology of central nervous system was observed in mast3a/b crispants.Conclusion: Our results support the possibility that MAST3 is a novel gene associated with NDD which could expand the genetic spectrum for NDD. The genotype-phenotype correlation may contribute to future genetic counseling.
Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials
Authors: Zhu Zhixin , Zhu Xiaoxia , Gu Lanfang , Zhan Yancen , Chen Liang , Li Xiuyang 
Published: January 2022

Background: Vitamin D supplementation improves the immune function of human body and can be a convenient way to prevent influenza. However, evidence on the protective effect of vitamin D supplementation on influenza from Randomized Controlled Trials (RCTs) is inconclusive.Methods: RCTs regarding the association between vitamin D supplementation and influenza were identified by searching PubMed, Cochrane library, Embase and Chinese Biomedical Database (CBM) from inception until present (last updated on 10 November 2021). Studies that reported dosages and durations of vitamin D supplementation and number of influenza infections could be included. Heterogeneity was assessed using Cochran's Q test and I2 statistics, the meta-analysis was conducted by using a random-effects model, the pooled effects were expressed with risk ratio (RR) with 95% confidence interval (95% CI).Results: 10 trials including 4859 individuals were ultimately eligible after scanning. There was no evidence of a significant heterogeneity among studies (I2 = 27%, P = 0.150). Meta-regression analysis finding indicated that country, latitude, average age, economic level, follow-up period and average daily vitamin D intake did not cause the statistical heterogeneity. The study finding indicates that substitution with vitamin D significantly reduces the risk of influenza infections (RR = 0.78, 95% CI:0.64–0.95). No evidence of publication bias was observed. Omission of any single trial had little impact on the pooled risk estimates.Conclusions: The meta-analysis produced a corroboration that vitamin D supplement has a preventive effect on influenza. Strategies for preventing influenza can be optimized by vitamin D supplementation.
Multi-Parametric Magnetic Resonance Imaging-Based Radiomics Analysis of Cervical Cancer for Preoperative Prediction of Lymphovascular Space Invasion
Authors: Huang Gang , Cui Yaqiong , Wang Ping , Ren Jialiang , Wang Lili , Ma Yaqiong , Jia Yingmei , Ma Xiaomei , Zhao Lianping 
Published: January 2022

BackgroundDetection of lymphovascular space invasion (LVSI) in early cervical cancer (CC) is challenging. To date, no standard clinical markers or screening tests have been used to detect LVSI preoperatively. Therefore, non-invasive risk stratification tools are highly desirable.ObjectiveTo train and validate a multi-parametric magnetic resonance imaging (mpMRI)-based radiomics model to detect LVSI in patients with CC and investigate its potential as a complementary tool to enhance the efficiency of risk assessment strategies.Materials and MethodsThe model was developed from the tumor volume of interest (VOI) of 125 patients with CC. A total of 1037 radiomics features obtained from conventional magnetic resonance imaging (MRI), including a small field-of-view (sFOV) high-resolution (HR)-T2-weighted MRI (T2WI), apparent diffusion coefficient (ADC), T2WI, fat-suppressed (FS)-T2WI, as well as axial and sagittal contrast-enhanced T1-weighted MRI (T1c). We conducted a radiomics-based characterization of each tumor region using pretreatment image data. Feature selection was performed using the least absolute shrinkage and selection operator method on the training set. The predictive performance was compared with single variates (clinical data and single-layer radiomics signatures) analyzed using a receiver operating characteristic (ROC) curve. Three-fold cross-validation performed 20 times was used to evaluate the accuracy of the trained classifiers and the stability of the selected features. The models were validated by using a validation set.ResultsFeature selection extracted the six most important features (3 from sFOV HR-T2WI, 1 T2WI, 1 FS-T2WI, and 1 T1c) for model construction. The mpMRI-combined radiomics model (area under the curve [AUC]: 0.940) reached a significantly higher performance (better than the clinical parameters [AUC: 0.730]), including any single-layer model using sFOV HR-T2WI (AUC: 0.840), T2WI (AUC: 0.770), FS-T2WI (AUC: 0.710), ADC maps (AUC: 0.650), sagittal, and axial T1c values (AUC: 0.710, 0.680) in the validation set.ConclusionBiomarkers using multi-parametric radiomics features derived from preoperative MR images could predict LVSI in patients with CC.
Self-Expandable Metallic Stent Implantation Combined With Bronchial Artery Infusion Chemoembolization in the Treatment of Lung Cancer With Complete Atelectasis
Authors: Li Xiaobing , Yin Meipan , Xie Pengfei , Liu Ying , Li Xiangnan , Qi Yu , Ma Yaozhen , Li Chunxia , Wu Gang 
Published: January 2022

BackgroundAtelectasis is a common complication of lung cancer, and there are few reports about the treatment methods. This study retrospectively analyzed the safety and effectiveness of endotracheal metal stent implantation combined with arterial infusion chemoembolization in the treatment of non-small cell lung cancer with complete atelectasis.MethodsThe clinical data of patients with non-small cell lung cancer and complete atelectasis treated by self-expandable metallic stent implantation combined with arterial infusion chemotherapy were retrospectively analyzed. The clinical efficacy was evaluated and postoperative adverse reactions were observed. Progression-free survival and overall survival were analyzed by Kaplan-Meier method.ResultsIn all, 42 endotracheal metallic stents were implanted in 42 patients under fluoroscopy. 5–7 days after stent implantation, CT showed that 24 patients (57.1%) had complete lung recruitment, and that 13 (31.0%) had partial lung recruitment. The technical success rate was 100%, and the clinical success rate was 88.1% (37/42). 5–7 days after stent implantation, bronchial artery infusion chemoembolization was performed in all patients. The median progression-free survival and overall survival were 6 months (95% CI: 2.04-9.66) and 10 months (95% CI: 7.22-12.79), respectively.ConclusionSelf-expandable metallic stent implantation combined with arterial infusion chemoembolization may be an effective and safe strategy in the treatment of lung cancer with atelectasis clinically.