bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytochrome P450 2E1 predicts liver functional recovery from donation after circulatory death using air-ventilated normothermic machine perfusion
Authors: Shi Ji-Hua , Yang Dong-Jing , Jin Qiang , Cheng Nuo , Shi Yuan-Bin , Bai Yang , Yu Dong-Sheng , Guo Wen-Zhi , Ge Guang-Bo , Zhang Shui-Jun 
Published: May 2022

AbstractThe optimal oxygen concentration is unclear for normothermic machine perfusion (NMP) of livers from donation after circulatory death (DCD). Our purposes were to investigate the effect of air-ventilated NMP on the DCD liver, analyze the underlying mechanism and select the targets to predict liver functional recovery with NMP. NMP was performed using the NMP system with either air ventilation or oxygen ventilation for 2 h in the rat liver following warm ischemia and cold-storage preservation. Proteomics and metabolomics were used to reveal the significant molecular networks. The bioinformation analysis was validated by administering peroxisome proliferator activator receptor-γ (PPARγ) antagonist and agonist via perfusion circuit in the air-ventilated NMP. Results showed that air-ventilated NMP conferred a better functional recovery and a less inflammatory response in the rat DCD liver; integrated proteomics and metabolomics analysis indicated that intrahepatic docosapentaenoic acid downregulation and upregulation of cytochrome P450 2E1 (CYP2E1) expression and activity were associated with DCD liver functional recovery with air-ventilated NMP; PPARγ antagonist worsened liver function under air-oxygenated NMP whereas PPARγ agonist played the opposite role. In conclusion, air-ventilated NMP confers a better liver function from DCD rats through the DAP-PPARγ-CYP2E1 axis; CYP2E1 activity provides a biomarker of liver functional recovery from DCD.
Functional characterization of α-Gal producing lactic acid bacteria with potential probiotic properties
Authors: Bamgbose Timothy , Alberdi Pilar , Abdullahi Isa O. , Inabo Helen I. , Bello Mohammed , Sinha Swati , Anvikar Anupkumar R. , Mateos-Hernandez Lourdes , Torres-Maravilla Edgar , Bermúdez-Humarán Luis G. , Cabezas-Cruz Alejandro , de la Fuente Jose 
Published: May 2022

AbstractThe possibility of exploiting the human immune response to glycan α-Gal for the control of multiple infectious diseases has been the objective of recent investigations. In this field of research, the strain ofEscherichia coliO86:B7 has been at the forefront, but this Gram-negative microorganism presents a safety concern and therefore cannot be considered as a probiotic. To address this challenge, this study explored the identification of novel lactic acid bacteria with a safe history of use, producing α-Gal and having probiotic potential. The lactic acid bacteria were isolated from different traditionally fermented foods (kununn-zaki,kindirmo, andpulque) and were screened for the production of α-Gal and some specific probiotic potential indicators. The results showed that Ten (10) out of forty (40) [25%] of the tested lactic acid bacteria (LAB) produced α-Gal and were identified asLimosilactobacillus fermentum, Levilactobacillus brevis, Agrilactobacillus composti, Lacticaseibacillus paracasei,Leuconostoc mesenteroidesandWeissella confusa. Four (4) LAB strains with highest levels of α-Gal were further selected for in vivo study using a mouse model (α1,3GT KO mice) to elucidate the immunological response to α-Gal. The level of anti-α-Gal IgG observed were not significant while the level of anti-α-Gal IgM was lower in comparison to the level elicited byE.coliO86:B7. We concluded that the lactic acid bacteria in this study producing α-Gal have potential probiotic capacity and can be further explored in α-Gal-focused research for both the prevention and treatment of various infectious diseases and probiotic development.
Thiazol-2-ylidenes as N-Heterocyclic carbene ligands with enhanced electrophilicity for transition metal catalysis
Authors: Zhang Jin , Li Tao , Li Xiangyang , Lv Anqi , Li Xue , Wang Zheng , Wang Ruihong , Ma Yangmin , Fang Ran , Szostak Roman , Szostak Michal 
Published: May 2022

AbstractOver the last 20 years, N-heterocyclic carbenes (NHCs) have emerged as a dominant direction in ligand development in transition metal catalysis. In particular, strong σ-donation in combination with tunable steric environment make NHCs to be among the most common ligands used for C–C and C–heteroatom bond formation. Herein, we report the study on steric and electronic properties of thiazol-2-ylidenes. We demonstrate that the thiazole heterocycle and enhanced π-electrophilicity result in a class of highly active carbene ligands for electrophilic cyclization reactions to form valuable oxazoline heterocycles. The evaluation of steric, electron-donating and π-accepting properties as well as structural characterization and coordination chemistry is presented. This mode of catalysis can be applied to late-stage drug functionalization to furnish attractive building blocks for medicinal chemistry. Considering the key role of N-heterocyclic ligands, we anticipate that N-aryl thiazol-2-ylidenes will be of broad interest as ligands in modern chemical synthesis.
Traffic forecasting with missing data via low rank dynamic mode decomposition of tensor
Authors: Zhang Xinyu , Zhang Yong , Wei Xiulan , Hu Yongli , Yin Baocai 
Published: May 2022

AbstractTraffic forecasting is an important part in realising intelligent traffic management, which helps traffic controllers and travellers make effective decisions. However, traffic forecasting accuracy is often affected by missing traffic data due to hardware and software failure. Therefore, accurate prediction based on incomplete traffic data is an important problem as well as a challenge. Though many approaches recover the missing values before prediction, the errors from the data‐filling step are likely to cause additional bias to the prediction result. Besides, this tactic is difficult to guarantee the timeliness and may impede real‐time prediction. In this case, a traffic forecasting model is proposed to directly predict traffic data with missing values. This model develops tensor formed dynamic mode decomposition, recording the dynamic information of traffic data into a state transition tensor. In addition, the model takes low rank property of the dynamic tensor and the similarity of temporal variation trend into consideration. In order to verify the effectiveness and the robustness of the proposed model, experiments were performed on two real‐world time series datasets. The results demonstrate that the model achieves better performance on forecasting than other baseline approaches under the impact of missing data.
Sequence of operations for real‐time control of microgrids and networked microgrids
Authors: Sheikholeslami Mehrdad , Yan Lei , Shahidehpour Mohammad , Gurung Niroj , Zheng Honghao , Vukojevic Aleksandar , Paaso Aleksi , Li Zuyi 
Published: May 2022

AbstractMicrogrids (MGs) provide a potential solution to accommodating renewable and distributed energy resources (DERs). MGs and the networked form of MGs, that is, networked MGs or NMGs, have received significant attention in the past two decades. However, several details that need to be considered for the practical operations of MGs and NMGs are often neglected in the literature. First, there is a need for a step‐by‐step sequence of operations (SOO) that clearly defines the procedures for changing the operation modes of MGs and NMGs for their reliable and resilient operation. Second, there is a need to develop a new control strategy for power exchange between networked MGs to ensure the information privacy and respect the electrical boundary of each MG. Third, there is a need for developing the model of MGs and NMGs in a real‐time simulator to safely evaluate the performance of the microgrid master controller (MMC) in making real‐time decisions and following the SOO. This paper proposes solutions for these three requirements and presents results to evaluate the performance of the proposed solutions. The IIT Campus Microgrid (ICM) and Bronzeville Community Microgrid (BCM), as well as their networked form, are selected as the practical testbeds and are modelled in real‐time digital simulator (RTDS). The RTDS model is interfaced with the MMC for real‐time data exchange and the operation of the MMC is tested to illustrate the importance of SOO in the real‐time control of MGs and NMGs.
A quarter century of spectroscopic monitoring of the nearby M dwarf Gl 514
Authors: Damasso M. , Perger M. , Almenara J. M. , Nardiello D. , Pérez-Torres M. , Sozzetti A. , Hara N. C. , Quirrenbach A. , Bonfils X. , Zapatero Osorio M. R. , Astudillo-Defru N. , González Hernández J. I. , Suárez Mascareno A. , Amado P. J. , Forveille T. , Lillo-Box J. , Alibert Y. , Caballero J. A. , Cifuentes C. , Delfosse X. , Figueira P. , Galadí-Enríquez D. , Hatzes A. P. , Henning Th. , Kaminski A. , Mayor M. , Murgas F. , Montes D. , Pinamonti M. , Reiners A. , Ribas I. , Béjar V. J. S. , Schweitzer A. , Zechmeister M. 
Published: May 2022

Context. Statistical analyses based on Kepler data show that most of the early-type M dwarfs host multi-planet systems consisting of Earth- to sub-Neptune-sized planets with orbital periods of up to ~250 days, and that at least one such planet is likely located within the habitable zone. M dwarfs are therefore primary targets to search for potentially habitable planets in the solar neighbourhood.
Aims. We investigated the presence of planetary companions around the nearby (7.6 pc) and bright (V = 9 mag) early-type M dwarf Gl 514, analysing 540 radial velocities collected over nearly 25 yr with the HIRES, HARPS, and CARMENES spectrographs.
Methods. The data are affected by time-correlated signals at the level of 2–3 m s−1 due to stellar activity, which we filtered out, testing three different models based on Gaussian process regression. As a sanity cross-check, we repeated the analyses using HARPS radial velocities extracted with three different algorithms. We used HIRES radial velocities and Hipparcos-Gaia astrometry to put constraints on the presence of long-period companions, and we analysed TESS photometric data.
Results. We find strong evidence that Gl 514 hosts a super-Earth on a likely eccentric orbit, residing in the conservative habitable zone for nearly 34% of its orbital period. The planet Gl 514b has minimum mass mb sin ib = 5.2 ± 0.9 M⊕, orbital period Pb = 140.43 ± 0.41 days, and eccentricity eb = 0.45−0.14+0.15. No evidence for transits is found in the TESS light curve. There is no evidence for a longer period companion in the radial velocities and, based on astrometry, we can rule out a ~0.2 MJup planet at a distance of ~3–10 astronomical units, and massive giant planets and brown dwarfs out to several tens of astronomical units. We discuss the possible presence of a second low-mass companion at a shorter distance from the host than Gl 514 b.
Conclusions. Gl 514 b represents an interesting science case for studying the habitability of planets on eccentric orbits. We advocate for additional spectroscopic follow-up to get more accurate and precise planetary parameters. Further follow-up is also needed to investigate the presence of additional planetary signals of less than 1 m s−1.
Intrafamiliäre Variabilität des Phänotyps der 5q-assoziierten spinalen Muskelatrophie am Beispiel von 2 Geschwistern
Authors: Becker Benedikt , Cordts Isabell , Deschauer Marcus 
Published: May 2022

ZUSAMMENFASSUNGDie 5q-assoziierte spinale Muskelatrophie (SMA) ist eine autosomal-rezessiv vererbte Erkrankung, die durch biallelische Defekte im SMN1-Gen (survival of motor neuron 1) auf Chromosom 5q verursacht wird. Der Gendefekt bewirkt einen fortschreitenden Untergang motorischer Vorderhornzellen im Rückenmark, was zu progredienten atrophen Paresen führt. Manifestationsalter und Schweregrad können sehr unterschiedlich sein. Die Anzahl der SMN2-Genkopien ist der entscheidende Modifier, es werden jedoch auch andere Faktoren vermutet. Anhand zweier Brüder mit 5q-assoziierter SMA soll gezeigt werden, dass trotz gleicher SMN2-Genkopienzahl erhebliche Unterschiede im Manifestationsalter und klinischen Phänotyp vorliegen können. Dies hat Implikationen für die genetische Beratung von gesunden Geschwistern von SMA-Patienten, da es zeigt, dass auch ältere Geschwister von Betroffenen ein Erkrankungsrisiko haben. Eine genetische Testung von Geschwistern kann nicht nur die Frage der Anlageträgerschaft beantworten, sondern hat auch einen prädiktiven Charakter. Dies ist aufgrund der seit einigen Jahren verfügbaren Therapieoptionen der SMA, deren Wirksamkeit bei frühem Therapiebeginn besonders hoch ist, von besonderer Bedeutung.
Rehabilitative Kompetenz im Akutbereich verankern: die
rehabilitationsbeauftragte Ärztin/der rehabilitationsbeauftragte
Arzt im Krankenhaus (Kurzfassung)
Authors: Beyer Joachim , Best Norman , Glaesener Jean Jacques , Kasprick Lysann , Reißhauer Anett , Liebl Max Emanuel 
Published: May 2022

ZusammenfassungDie Übergänge aus der Krankenhausbehandlung in die nachfolgenden
Versorgungssysteme haben sich bereits durch das eingeführte
Entlassmanagement verbessert. Jedoch gewährleisten weder die
Krankenhausbehandlung selbst noch das Entlassmanagement derzeit die volle
Ausschöpfung vorhandener Rehabilitationspotentiale.  In den
Akutkliniken fehlt im ärztlichen Bereich eine ausreichende
rehabilitationsmedizinische Kompetenz, und zwar sowohl im Hinblick auf die
Durchführung der stationären Behandlung mit rehabilitativer
Zielsetzung (vgl. § 39 SGB V, § 43 SGB IX) als auch im Hinblick
auf die rehabilitativ ausgerichtete Weiterversorgung einschließlich der
zeitnahen Vermittlung in eine bedarfsgerechte Rehabilitationseinrichtung.
Rehabilitationsmedizinische Kompetenz innerhalb von
Krankenhäusern kann über das Einführen
einer/eines ärztlichen Reha-Beauftragten mit klaren
Qualifikationsvorgaben erreicht werden.
Die COVID-19-Pandemie und psychische Störungen bei Minderjährigen
Authors: Kölch Michael 
Published: May 2022

ZUSAMMENFASSUNGDie psychosozialen Folgen der COVID-Pandemie auf Minderjährige müssen differenziert betrachtet werden: Belastungen bedeuten nicht, dass auch eine psychische Störung besteht. Nicht alle Kinder sind gleichermaßen gefährdet für psychosoziale Folgen. Bereits vor der Pandemie bekannte Risikofaktoren sind während und nach der Pandemie gültig. Bei Kindern, die bereits an einer psychischen Störung leiden, kann die Pandemie zur Verschlechterung der Symptomatik oder der Teilhabe führen. Schwachstellen in der Versorgung wurden deutlich. Andererseits untersuchte eine Vielzahl an Studien die psychischen Auswirkungen der Pandemie. Langzeitstudien und auf Risikogruppen ausgerichtete Studien sind zukünftig notwendig. Die Pandemie unterstreicht, dass die psychische Gesundheit von Kindern eines der wichtigsten Gesundheitsthemen in Deutschland ist. Kurzfristig bedarf es der Flexibilisierung in der Versorgung, um Mehrbedarfe in der Versorgung zu begegnen. Langfristig ist es notwendig, in der Versorgung Strukturen einzuführen, die eine risikoadaptierte Prävention, Behandlung und Teilhabeunterstützung ermöglichen. Innovative Versorgungsstrukturen müssten auch rechtskreisübergreifend gestaltet sein.
Utility of a canine TSH assay for diagnosis and monitoring of feline hyperthyroidism
Authors: Urbanschitz Tobias , Burgener Iwan A. , Zeugswetter Florian K. 
Published: May 2022

AbstractObjective This retrospective study was initiated to evaluate the utility of TSH measurements using a common canine TSH assay to diagnose and monitor feline hyperthyroidism after radioiodine or thyreostatic drug treatment.Material and methods The electronic database of the University of Veterinary Medicine Vienna was searched for combined TSH and T4 measurements. 217 pairs of TSH and T4 from 136 cats with possible hyperthyroidism were assigned to group A (untreated; n = 24) and B (treated; n = 193). Measurements in group B were then subcategorized according to T4 concentrations (reference range 15–50 nmol/L): group B1 = elevated T4 (n = 46), group B2 = normal T4 (n = 84) and group B3 = decreased T4 (n = 63). Group B2 was further divided into cats with low normal (group B2a; n = 35), medium normal (group B2b; n = 29) and high normal (group B2c; n = 20) T4 concentrations.Results TSH was detectable in 4 (17 %) of the 24 untreated cats (group A) and did not return to normal despite seemingly successful therapy in two. Increased TSH concentrations were observed in 3.6 % of the treated cats in group B2 and 2.9 %, 6.9 %, and 0 % in subgroups B2a, B2b and B2c, respectively. Forty-four percent of the treated cats with a decreased T4 (group B3) had an increased TSH concentration. TSH correlated with treatment length (r = 0.358, p = 0.004) and was significantly higher in cats treated for more than 3 months (p = 0.008).Conclusion TSH was detectable in a significant number of untreated hyperthyroid cats and thus this parameter should not be used to definitively rule out feline hyperthyroidism. Furthermore, the very low prevalence of increased TSH concentrations in treated hyperthyroid cats with a normal T4 and cost benefit calculations do not support the routine measurement of TSH in these cats. The fact that TSH correlated with time since treatment start and 56 % of the cats with a decreased T4 had TSH concentrations within the reference limits, suggests delayed recovery of the pituitary thyrotrophs which might explain the low prevalence of subclinical hypothyroidism in the present study.Clinical relevance TSH measurement in cats with suspected or treated hyperthyroidism using a canine assay lacks diagnostic sensitivity and can only complement therapeutic decision-making.
Point-of-Care Ultrasound in Neurology – Report of the EAN SPN/ESNCH/ERcNsono Neuro-POCUS Working Group
Authors: Valaikiene Jurgita , Schlachetzki Felix , Azevedo Elsa , Kaps Manfred , Lochner Piergiorgio , Katsanos Aristeidis H. , Walter Uwe , Baracchini Claudio , Bartels Eva , Školoudík David 
Published: May 2022

AbstractIn the last decade, ultrasound examination in neurology has been undergoing a significant expansion of its modalities. In parallel, there is an increasing demand for rapid and high-quality diagnostics in various acute diseases in the prehospital setting, the emergency room, intensive care unit, and during surgical or interventional procedures. Due to the growing need for rapid answers to clinical questions, there is particular demand for diagnostic ultrasound imaging. The Neuro-POCUS working group, a joint project by the European Academy of Neurology Scientific Panel Neurosonology, the European Society of Neurosonology and Cerebral Hemodynamics, and the European Reference Centers in Neurosonology (EAN SPN/ESNCH/ERcNsono Neuro-POCUS working group), was given the task of creating a concept for point-of-care ultrasound in neurology called “Neuro-POCUS”. We introduce here a new ultrasound examination concept called point-of-care ultrasound in neurology (Neuro-POCUS) designed to streamline conclusive imaging outside of the ultrasound center, directly at the bedside. The aim of this study is to encourage neurologists to add quick and disease-oriented Neuro-POCUS to accompany the patient in the critical phase as an adjunct not a substitution for computed tomography, magnetic resonance imaging, or standard comprehensive neurosonology examination. Another goal is to avoid unwanted complications during imaging-free periods, ultimately resulting in advantages for the patient.
The Antiobesity Effect and Safety of GLP-1 Receptor Agonist in
Overweight/Obese Patients Without Diabetes: A Systematic Review and
Meta-Analysis
Authors: Guo Xiaonan , Zhou Zhibo , Lyu Xiaorui , Xu Hanyuan , Zhu Huijuan , Pan Hui , Wang Linjie , Yang Hongbo , Gong Fengying 
Published: May 2022

AbstractAim To determine the antiobesity effect and safety of glucagon-like
peptide-1 receptor agonist (GLP-1RA) including liraglutide, exenatide and
semaglutide treatment in overweight/obese patients without diabetes. The
random-effect model was used to pool data extracted from included literatures.
The weighted mean difference (WMD), odds ratio and 95% confidence
interval (CI) were used to present the meta-analysis results (PROSPERO
registration number: CRD 42020173199). The sources of intertrial heterogeneity,
bias and the robustness of results were evaluated by subgroup analysis,
sensitivity analysis and regression analysis, respectively. A total of 24 RCTs
were recruited in the present analysis which included 5867 patients. The results
showed that the treatment of overweight/obese patients without diabetes
with GLP-1RAs including liraglutide, exenatide and semaglutide significantly
achieved greater weight loss than placebo [WMD=–5.39,
95% CI (–6.82, –3.96)] and metformin
[WMD=–5.46, 95% CI (–5.87, –5.05)]. The
subgroup analysis showed that semaglutide displayed the most obvious antiobesity
effect in terms of weight loss, the reduction of body mass index (BMI) and waist
circumference (WC). However, GLP-1RAs treatments had more gastrointestinal
adverse events (such as nausea and vomiting) than placebo and Met. The subgroup
analysis also represented that semaglutide displayed the lowest risk of
gastrointestinal adverse events among three kinds of GLP-1RAs. Our meta-analysis
demonstrated that GLP-1RA had a superior antiobesity effect than
placebo/Met in overweight/obese patients without diabetes in
terms of body weight, BMI, and WC, especially for semaglutide, which had more
obvious antiobesity effect and lower GI adverse events than liraglutide and
exenatide.
Assembly of Pyran-Fused Isoquinolines via Rhodium-Catalyzed Double Annulations of Methyl Benzimidates with Diazo Compounds
Authors: Wu Yinsong , Zhang Enshen , He Xinwei , Shang Yongjia , Duan Jiahui , Xu Keke 
Published: May 2022

AbstractA variety of pyran-fused isoquinoline derivatives were prepared in moderate to good yields through the rhodium-catalyzed dual C–H functionalization/annulation of methyl benzimidates and diazo compounds. A one-pot procedure, broad substrate scope, diversified products, and mild reaction conditions make this transformation a powerful tool for the synthesis of fused heteroarenes. In addition, the synthetic application was extended by large-scale synthesis and late-stage functionalization via Pd-catalyzed Suzuki–Miyaura, Heck, and Sonogashira cross-coupling reactions. Furthermore, a photophysical survey reveals that the pyran-fused isoquinoline products exhibit fluorescence properties and show potential for exploring fluorescent material applications.