bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early versus delayed enteral nutrition for neonatal hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia: a randomized controlled trial
Authors: Hu Ya , Chen Feng , Xiang Xinyu , Wang Fang , Hua Ziyu , Wei Hong 
Published: August 2022

Abstract
Background
The practice of therapeutic hypothermia (TH) is widely used for neonatal hypoxic-ischemic encephalopathy (HIE) despite its corresponding feeding strategies are still controversial. This randomized controlled trial (RCT) demonstrated to evaluate the effect of early vs. delayed enteral nutrition on the incidence of feeding intolerance (FI) and other association during TH.

Methods
This single center, parallel-group, and no-blinded RCT was processed in a level III, and academic neonatal intensive care unit. Infants who were diagnosed with HIE and undertaken TH from September 2020 to August 2021 were enrolled. Participants were randomized to receive enteral nutrition either during TH/rewarming (early enteral nutrition, EEN) or after TH (delayed enteral nutrition, DEN) according to a recommend enteral feeding protocol. All data were analyzed using SPSS 26.0 software with a p-value< 0.05 was considered statistically significant.

Results
Ninety-two infants were enrolled after randomization, but 12 (13.04%) cases including 3 (3.26%) deaths were excluded from eventually analyzed, who did not initiate or discontinue the intervention. 80 cases (42 and 38 in the EEN and DEN group, respectively) who completed the interventions were eventually analyzed. Besides initial time of enteral feeds, two groups had processed the same feeding method. Total 23 (25.0%) cases developed FI, and no difference of morbidity was found between two groups (23.4% vs 26.7%, p = 0.595; Log Rank, p = 0.803). There was no case died or developed late-onset bloodstream and no difference of the incidence of hypoglycemia or weight gain was found (p > 0.05). The percentage of infants who had not reaching the goal of full enteral feeding volume between the two groups was similar (21.43% vs 23.68%, p = 0.809). The average time of parenteral nutrition, reaching full enteral feeds and hospital stay were shorter in the EEN group compared with the DEN group with significant differences (8.81 ± 1.67 vs 10.61 ± 2.06 days, p < 0.001; 9.91 ± 1.88 vs 12.24 ± 2.50 days, p < 0.001; 12.55 ± 4.57 vs 16.47 ± 5.27 days, p = 0.001 respectively).

Conclusions
Compared with delayed enteral nutrition, introduction of early enteral nutrition according to a recommend feeding strategy for neonatal HIE undergoing TH may be feasible and safe.FI is frequent in this high-risk group of infants which should not be ignored during feeding process.

Trial registration
The Chinese Clinical Trial Registry,ChiCTR2000038193, 2020-9-13, https://www.chictr.org.cn.
The effect of opioid-sparing anesthesia regimen on short-term cognitive function after thoracoscopic surgery: a prospective cohort study
Authors: Zhao Hong , Han Qiaoyu , Shi Chuan , Feng Yi 
Published: August 2022

Abstract
Background
As type of surgery and opioids are suggested risk factors for the development of cognitive decline after surgery, we evaluated the effect of an opioid-sparing anesthesia regimen involving preoperative erector spinae block and continuous infusion of flurbiprofen on the incidence of cognitive decline after video-assisted thoracoscopic surgery.

Methods
In this observational study, patients over 18 years old presenting for elective video-assisted thoracoscopic surgery were divided into two groups, the erector spinae plane block group (ESPB group, who received preoperative single shot of bi-level ESPB at T4 and T6 levels) and the control group who received intercostal nerve blocks through T5 to T7 intercostal spaces along mid-axillary line after surgery. Continuous infusion of flurbiprofen (8 mg/h) and intravenous oxycodone rescue (1 mg/bolus, lockout time 10 minutes) were provided as postoperative analgesics. Cognitive function was measured one day before and 48 h after surgery with brief Cogstate computerized battery (CCB).

Results
There were 60 patients included with 30 in each group. Perioperative sufentanil dose was significantly reduced in ESPB group. Nine (30%) and 15 (50%) patients had delayed neurocognitive recovery in the ESPB group and the control group respectively. Psychomotor speed and visual attention tests were the two tests that patients showed cognitive decline. The results of multivariate regression revealed that patients who were more than 53.5 years of age (OR 9.213, 95% CI 1.789, 47.437, P = 0.008) and low levels of education (less than 9 years of complimentary education) (OR 6.829, 95% CI 1.068, 43.677, P = 0.042) were independent risk factors for postoperative delayed neurocognitive recovery. For subgroup analysis, ESPB could reduce the occurrence of delayed neurocognitive recovery in patients with both risk factors (6/10 (60%) vs. 11/11 (100%), P = 0.004) compared to the control group.

Conclusions
Middle-aged people and low levels of education are independent risk factors for delayed neurocognitive recovery after thoracoscopic surgery. ESPB has the potential to prevent cognitive decline in high-risk patients.

Trial registration
ChiCTR1800014508 (www.chictr.org.cn, January 17, 2018; Hong Zhao, M.D.). URL: http://www.chictr.org.cn/showproj.aspx?proj=24778. The date of the enrolment of the first participant to the trial was January 22, 2018.
Importance of Candida infection and fluconazole resistance in women with vaginal discharge syndrome in Namibia
Authors: Dunaiski Cara M. , Kock Marleen M. , Jung Hyunsul , Peters Remco P. H. 
Published: August 2022

AbstractBackgroundVaginal discharge syndrome (VDS) is a common condition. Clinical management targets sexually transmitted infections (STIs) and bacterial vaginosis (BV); there is limited focus onCandidainfection as cause of VDS. Lack ofCandidatreatment coverage and, if present, antifungal resistance may result in VDS treatment failure. This study aimed to determine the prevalence ofCandidainfection, antifungal resistance, and coinfections in Namibian women with VDS.MethodsA cross-sectional study was performed using 253 vaginal swabs from women with VDS in Namibia. Demographic data was collected, and phenotypic and molecular detection ofCandidaspecies was performed followed by fluconazole susceptibility testing ofCandidaisolates. BV was diagnosed using Nugent score microscopy; molecular detection ofChlamydia trachomatis,Neisseria gonorrhoeaeandTrichomonas vaginaliswas performed.ResultsCandidaspecies was detected in 110/253 women (43%). Ninety women (36%) hadCandida albicansand 24 (9.5%) had non-albicansCandidaspecies. The non-albicans species detected were 19 (17%)Candida glabrata, 4.0 (3.5%)Candida krusei, and 1.0 (0.9%)Candida parapsilosis.Candida albicanswere more frequently isolated in younger (p = 0.004) and pregnant women (p = 0.04) compared to non-albicansCandidaspecies. Almost all (98%)Candida albicansisolates were susceptible to fluconazole while all non-albicansCandidaspecies were fluconazole resistant. STIs were diagnosed in 92 women (36%): 30 (12%) withC. trachomatis, 11 (4.3%)N. gonorrhoeae, and 70 (28%)T. vaginalis; 98 (39%) women had BV.Candidainfection alone was diagnosed in 30 women (12%), combined with STIs in 42 women (17%) and was concurrent with BV in 38 women (15%).Candidainfection was more often detected in swabs from women withoutC. trachomatisdetected (6.4% vs. 16%; OR 0.30; 95% CI 0.10–0.77,p = 0.006).ConclusionsThe high prevalence ofCandidainfection, especially those due to non-albicansCandidaspecies that are resistant to fluconazole, is a great concern in our setting and may lead to poor treatment outcomes. Access to microbiological testing forCandidaspecies in the context of syndromic management is warranted.
The influence of demography and referral medical specialty on the detection of autoantibodies to HEP-2 cells in a large sample of patients
Authors: Santos Wilton Ferreira Silva , Cantuária Ana Paula de Castro , Félix Daniele de Castro , Nardes Leandro Kegler , de Melo Igor Cabral Santos 
Published: August 2022

Abstract
Background
The prevalence of anti-cell autoantibodies detected by indirect immunofluorescence assay on HEp-2 cells (HEp-2-IIFA) increases with age and is higher in female sex. The number of medical specialties that use HEp-2-IIFA in the investigation of autoimmune diseases has increased lately. This study aimed to determine the prevalence and patterns of autoantibodies on HEp-2-IIFA according to demographics variables and referring medical specialties.

Methods
A retrospective analysis of the HEp-2-IIFA carried out between January and June of 2017 was performed. The International Consensus on Antinuclear Antibodies Patterns (ICAP) and the Brazilian Consensus on Autoantibodies were used for patterns definition on visual reading of the slides. Anti-cell (AC) codes from ICAP and Brazilian AC codes (BAC) were used for patterns classification.

Results
From 54,990 samples referred for HEp-2-IIF testing, 20.9% were positive at titer ≥ 1/80. HEp-2-IIFA positivity in females and males was 24% and 12%, respectively (p < 0.0001). The proportion of positive results in the 4 age groups analyzed: 0–19, 20–39, 40–59, and ≥ 60 years was 23.3, 20.2, 20.1, and 22.8%, respectively (p < 0.0001). Considering all positive sera (n = 11,478), AC-4 nuclear fine speckled (37.7%), AC-2 nuclear dense fine speckled (21.3%), BAC-3 nuclear quasi-homogeneous (10%) and mixed/composite patterns (8.8%) were the most prevalent patterns. The specialties that most requested HEp-2-IIFA were general practitioner (20.1%), dermatology (15%), gynecology (9.9%), rheumatology (8.5%), and cardiology (5.8%). HEp-2-IIFA positivity was higher in patients referred by rheumatologists (35.7% vs. 19.6%) (p < 0.0001). Moderate (46.4%) and high (10.8%) titers were more observed in patients referred by rheumatologists (p < 0.0001). We observed a high proportion of mixed and cytoplasmic patterns in samples referred by oncologists and a high proportion of BAC-3 (nuclear quasi-homogeneous) pattern in samples referred by pneumologists.

Conclusions
One-fifth of the patients studied were HEp-2-IIFA-positive. The age groups with more positive results were 0–19 and ≥ 60 years. AC-4, AC-2, BAC-3 and mixed/composite patterns were the most frequent patterns observed. Rheumatologists requested only 8.5% of HEp-2-IIFA. Positive results and moderate to high titers of autoantibodies were more frequent in patients referred by rheumatologists.
ADCY5-related dyskinesia: a case report
Authors: Chen Shih-Ying , Ho Chen-Jui , Lu Yan-Ting , Lin Chih-Hsiang , Tsai Meng-Han 
Published: August 2022

AbstractAdenylyl cyclase 5 (ADCY5) related dyskinesia is a rare disorder characterized by early-onset paroxysmal choreoathetosis, dystonia, myoclonus, or a combination of the above, which primarily involved the limbs, face, and neck. Other common clinical features are axial hypotonia and episodic exacerbation of dyskinesia. Both sporadic and inherited cases have been reported and the predomiant mode of inheritance is autosomal dominant. Herein, we describe the first ADCY5-related dyskinesia patient in Taiwan.
MIC17A is a novel diagnostic marker for feline toxoplasmosis
Authors: Chen Jinling , Xue Lilan , Hu Hongxia , Yin Xiaoyan , Cao Hui , Shen Bang 
Published: August 2022

AbstractToxoplasma gondiiis a widespread parasitic pathogen that infect humans and all warm-blooded animals, causing abortion and stillbirth in pregnant women and animals, as well as life threatening toxoplasmosis in immune compromised individuals. Felines are the only definitive hosts ofToxoplasmaand oocysts shed by infected felines are the major source of infection for humans and other animals. Given the critical role of felines forT. gondiitransmission, control of feline toxoplasmosis has significant impacts on reducing the overall prevalence of animal and human toxoplasmosis. However, reliable diagnosis of feline toxoplasmosis is still challenging. In this study, we found that the putative micronemal protein 17A (MIC17A) that was abundantly expressed inToxoplasmamerozoites is a good diagnostic marker for serological diagnosis ofToxoplasmainfection in felines.T. gondiiencodes four paralogs of MIC17A in total and the expression of three of them is drastically upregulated in merozoites than in tachyzoites. In contrast, when proteins like GRA1 and MIC3 that are more abundantly expressed in tachyzoites than in merozoites were used as diagnostic antigens to test feline toxoplasmosis, they reacted withToxoplasmaspecific IgG antibodies poorly. Taken together, these results suggest that merozoite antigens are better suited for the diagnosis of feline toxoplasmosis than antigens that are highly expressed at tachyzoite or bradyzoite stages.
Serum Levels of Myo-inositol Predicts Clinical Outcome 1 Year After Aneurysmal Subarachnoid Hemorrhage
Authors: Johansson Conny , Koskinen Lars-Owe D. , Sjöberg Rickard L. , Lindvall Peter 
Published: August 2022

BACKGROUND:
Early prognostication of long-term outcome in patients suffering from spontaneous subarachnoid hemorrhage (SAH) remains a challenge. No biomarkers are routinely used for prognostication. A previous study has indicated that the metabolite myo-inositol (MI) may be used to predict long-term outcome.

OBJECTIVE:
To investigate if MI measured in serum correlates with long-term clinical outcome in patients suffering from SAH.

METHODS:
We conducted an observational cohort study including 88 patients treated for SAH at Umeå University Hospital. Serum samples were collected in the hospital, and a gas chromatography/mass spectroscopy method was used to quantitatively measure MI. Patients were assessed after 1 year using the Glasgow Outcome Scale Extended and dichotomized to favorable or unfavorable outcome. Differences in MI levels between the 2 groups were analyzed.

RESULTS:
There was no difference in MI levels between the groups upon admission. Myo-inositol levels decreased over time in the entire study population. The decrease was significantly larger in the unfavorable outcome group. A receiver operating characteristics analysis yielded an area under the curve of 0.903 (CI 0.8-1.0, P < .001) for the MI value on day 7 to predict favorable outcome after 1 year.

CONCLUSION:
Myo-inositol measured in serum may aid prognostication of outcome in patients with SAH. The mechanism behind this remains unclear, although it can be theorized to reflect processes leading to delayed cerebral ischemia, which affects long-term outcome. This is the first study to quantitively measure MI in serum for prognostication of outcome in patients with SAH.
Enhancement of the activity of the antimicrobial peptides HNP1 and LL-37 by bovine pancreatic ribonuclease A
Authors: Ericksen Bryan 
Published: August 2022

Background: HNP1, LL-37, and HBD1 are antimicrobial against Escherichia coli ATCC 25922 at the standard inoculum but less active at higher inocula. Methods: The virtual colony count (VCC) microbiological assay was adapted for high inocula and the addition of yeast tRNA and bovine pancreatic ribonuclease A (RNase). 96-well plates were read for 12 hours in a Tecan Infinite M1000 plate reader and photographed under 10x magnification. Results: Adding tRNA 1:1 to HNP1 at the standard inoculum almost completely abrogated activity. Adding RNase 1:1 to HNP1 at the standard inoculum of 5x105 CFU/mL did not enhance activity. Increasing the inoculum to 6.25x107 CFU/mL almost abrogated HNP1 activity. However, adding RNase 25:1 to HNP1 enhanced activity. Adding both tRNA and RNase resulted in enhanced activity, indicating that the enhancement effect of RNase overwhelms the inhibiting effect of tRNA when both are present. HBD1 activity at the standard inoculum was almost completely abrogated by the addition of tRNA, but LL-37 activity was only slightly inhibited by tRNA. At the high inoculum, LL-37 activity was enhanced by RNase. HBD1 activity was not enhanced by RNase. RNase was not antimicrobial in the absence of antimicrobial peptides. Cell clumps were observed at the high inoculum in the presence of all three antimicrobial peptides and at the standard inoculum in the presence of HNP1+tRNA. Conclusions: Antimicrobial peptide-ribonuclease combinations have the potential to be active against high cell concentrations and biofilms, conditions where the antimicrobial agent alone is relatively ineffective.
Inclusive pedagogy in online simulation-based learning in undergraduate nursing education: A scoping review protocol
Authors: Langan Lisa , Halligan Phil , Frazer Kate , Darley Andrew , Goodman Lizbeth , Redmond Catherine 
Published: August 2022

Background: Education is recognised as a constitutional right, however, access to and participation in higher education can be challenging for some students. This has led to the development of various international and local initiatives promoting inclusion, which has increased student representation from marginalised groups. In order to support growing student diversity, teaching and learning (T&L) strategies must encompass inclusive pedagogical principles. Technological advancements have improved opportunities for online T&L strategies and these are becoming an integral component of curricula in undergraduate nursing programmes. Online simulation-based learning (SBL) has gathered momentum in nursing education over the past twenty years. However, it is unclear from the evidence-base how inclusive this educational approach is, and how it can best support the growing diversity among nursing students. This paper outlines the protocol for a scoping review that aims to systematically and comprehensively map the available published and unpublished literature on inclusive pedagogy in online SBL in undergraduate nursing education. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for systematic review protocols (PRISMA-P) guided this protocol. Arksey and O'Malley (2005) six-stage methodology framework, the Joanna Briggs Institute (JBI) guidelines (Peters et al., 2020) and the PRISMA extension for scoping reviews (PRISMA-ScR) will guide the proposed scoping review (Tricco et al., 2018). Conclusion: It is envisaged that this scoping review will give a broad overview of the evidence for inclusive pedagogy in online SBL at this point. The findings of this review will be used to inform future policy and the pedagogical and technological design of online SBL activities and assist nurse educators to meet the current requirement of inclusive practice.
Impact of daily, oral pre-exposure prophylaxis on the risk of bacterial sexually transmitted infections among cisgender women: a systematic review and narrative synthesis
Authors: Papageorgiou Vasiliki , Crittendon Erica , Coukan Flavien , Davies Bethan , Ward Helen 
Published: August 2022

Background: There are concerns that the use of pre-exposure prophylaxis (PrEP) may result in an increased incidence of sexually transmitted infections (STIs). Evidence for this is mixed and has mostly been based on reviews focussed on gay and bisexual men and transgender women, while none have summarised evidence in cisgender women. Methods: We conducted a systematic review to explore whether daily, oral PrEP use is associated with changes in bacterial STI occurrence (diagnoses or self-reported) and/or risk among HIV seronegative cisgender women (ciswomen). The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) tool. Results: We included 11 full text articles in a narrative synthesis, with the studies published between 2012 and 2021. The studies were mostly based in Africa (n=7, 63.6%) and reported on 3168 ciswomen using PrEP aged 16–56 years. Studies had marked differences in variables, including measurements and definitions (e.g., STI type) and limited data available looking specifically at ciswomen, principally in studies with both male and female participants. The limited evidence suggests that PrEP use is not associated with increased STI rates in ciswomen generally; however, adolescent girls and young women in Sub Saharan Africa have a higher prevalence of bacterial STIs prior to PrEP initiation, compared to adult ciswomen and female sex workers. Conclusions: We suggest future PrEP research make efforts to include ciswomen as study participants and report stratified results by gender identity to provide adequate data to inform guidelines for PrEP implementation. PROSPERO registration: CRD42019130438
Country Risk and Wooden Furniture Export Trade: Evidence from China
Authors: Cai Yingli , Zhu Hongge , Chen Zhenhuan , Geng Yuan 
Published: August 2022

Abstract
Wooden furniture is the main product of the forest products trade, and activities associated with its international trade currently face many risks, representing a degree of uncertainty in the wooden furniture export trade. To explore the impact of country risk on China's wooden furniture export trade, panel data from 1995 to 2020 are used as a basis for this study, in which the impact of the country risk of trading partners on China's wooden furniture export trade is empirically analyzed using a stochastic frontier gravity model. The research shows that the economic scale and population scale of the trading partners and China, forest resource endowment, and exchange rate fluctuation all have a significant impact on the export trade of Chinese wooden furniture. The economic and financial risks of trading partners have a notable negative influence on China's wooden furniture export trade, but political risk has a positive effect. The export efficiency of China's wooden furniture is at a moderate level, and there is a huge imbalance between different trading partners.
Waveguide scattering antennas made by direct laser writing in bulk glass for spectrometry applications in the short-wave IR
Authors: Callejo M. , Bonduelle M. , Morand A. , Zhang G. , Lv J. , Cheng G. , D’Amico C. , Stoian R. , Martin G. 
Published: August 2022

A buried straight waveguide perturbed periodically by six antennas composed of submicronic cylinder voids is entirely fabricated using ultrafast laser photoinscription. The light scattered from each antenna is oriented vertically and is detected by a short-wave IR camera bonded to the surface of the glass with no relay optics. The response of each antenna is analyzed using a wavelength tunable laser source and compared to simulated responses verifying the behavior of the antenna. These results show the good potential of the direct laser writing technique to realize monolithic embedded detectors by combining complex optical functions within a 3D design. A wavelength meter application with a spectral resolution of 150 pm is proposed to demonstrate this combination.
Optimized design of an ultrasensitive tapered dual-hole fiber gas pressure sensor operating near the dispersion turning point
Authors: Wang Xinyu , Ling Qiang , Luo Si , Tao Jihong , Cai Mingda , Yu Zhangwei , Chen Daru 
Published: August 2022

An ultrasensitive gas pressure sensor based on a tapered dual-hole fiber working near the dispersion turning point is proposed. The gas pressure sensing characteristics and optimization method are investigated. The fiber structural parameters have been optimized to obtain the maximal sensitivity of the dual-peak interval up to 251.72 nm/MPa with a linearity of 98.3% in the pressure range from 0.1 to 0.6 MPa. The sensitivity is at least 1 order of magnitude higher than that of the Mach–Zehnder-interference-based gas pressure sensor. Therefore, the high sensitivity, good linearity, and the compact size make the proposed sensor more competitive in the field of gas pressure monitoring.