bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rogue Planet Helps to Populate the Distant Kuiper Belt
Authors: Huang 黄 Yukun 宇坤 , Gladman Brett , Beaudoin Matthew , Zhang Kevin 
Published: October 2022

Abstract
The orbital distribution of trans-Neptunian objects (TNOs) in the distant Kuiper Belt (with semimajor axes beyond the 2:1 resonance, roughly a = 50–100 au) provides constraints on the dynamical history of the outer solar system. Recent studies show two striking features of this region: (1) a very large population of objects in distant mean-motion resonances with Neptune, and (2) the existence of a substantial detached population (nonresonant objects largely decoupled from Neptune). Neptune migration models are able to implant some resonant and detached objects during the planet migration era, but many fail to match a variety of aspects of the orbital distribution. In this work, we report simulations carried out using an improved version of the GPU-based code GLISSE, following 100,000 test particles per simulation in parallel while handling their planetary close encounters. We demonstrate for the first time that a 2 Earth-mass rogue planet temporarily present during planet formation can abundantly populate both the distant resonances and the detached populations, surprisingly even without planetary migration. We show how weak encounters with the rogue planet greatly increase the efficiency of filling the resonances, while also dislodging TNOs out of resonance once they reach high perihelia. The rogue’s secular gravitational influence simultaneously generates numerous detached objects observed at all semimajor axes. These results suggest that the early presence of additional planet(s) reproduces the observed TNO orbital structure in the distant Kuiper Belt.
Development and validation of a new robust RP-HPLC method for simultaneous quantitation of insulin and pramlintide in non-invasive and smart glucose-responsive microparticles
Authors: Emami Jaber , Haghighi Maryam , Rostami Mahboobeh , Minaiyan Mohsen 
Published: October 2022

Background and purpose:
Since insulin and pramlintide cooperate in glucose hemostasis, co-administration and quantitation of them in pharmaceutical preparations are imperative. A simple, rapid, sensitive, and isocratic RP-HPLC method was developed and validated for simultaneous quantitation of insulin and pramlintide in loading and in-vitro release studies of a glucose-responsive system to improve the control of hyperglycemic episodes in diabetic patients.

Experimental approach:
The isocratic RP-HPLC separation was achieved on a C18 µ-Bondopak column (250 mm × 4.6 mm) using a mobile phase of water:acetonitrile:trifluoroacetic acid (65:35:0.1%) at a flow rate of 1 mL/min in an ambient temperature. Both proteins were detected using a UV detector at 214 nm. The method was validated for specificity, linearity, precision, accuracy, the limit of detection, the limit of quantification, and robustness.

Findings/Results:
Linearity was obtained in the concentration range of 30 to 360 μg/mL for insulin and 1.5 to 12 μg/mL for pramlintide. The results were validated statistically and recovery studies confirmed the great accuracy and precision of the proposed method. The robustness of the method was also confirmed through small changes in pH, mobile phase composition, and flow rate.

Conclusion and implications:
The method was found to be simple, specific, precise, and reproducible. It was applied for the determination of loading capacity, entrapment efficiency, and in-vitro release studies of insulin and pramlintide in a smart glucose-responsive microparticle. Co-delivery of insulin and pramlintide could be a new intervention in diabetes management and concurrent quantitation of these two proteins is, therefore, essential.
The design and evaluation of the antimicrobial activity of a novel conjugated penta-ultrashort antimicrobial peptide in combination with conventional antibiotics against sensitive and resistant strains of S. aureus and E. coli.
Authors: Darwish Rula , Almaaytah Ammar , Salama Ali 
Published: October 2022

Background and purpose:
Antimicrobial resistance still constitutes a major health concern to the global human population. The development of new classes of antimicrobial agents is urgently needed to thwart the continuous emergence of highly resistant microbial pathogens.

Experimental approach:
In this study, we have rationally designed a novel conjugated ultrashort antimicrobial peptide. The peptide named naprolyginine was challenged against representative strains of wild-type and multidrug-resistant bacteria individually or in combination with individual antibiotics by employing standard antimicrobial and checkerboard assays.

Findings / Results:
Our results displayed that the peptide exhibits potent synergistic antimicrobial activity against resistant strains of gram-positive and gram-negative bacteria when combined with individual antibiotics. Additionally, the peptide was evaluated for its hemolytic activity against human red blood cells and displayed negligible toxicity.

Conclusion and implications:
Naprolyginine could prove to be a promising candidate for antimicrobial drug development.
Evaluation of the osteogenic effect of apigenin on human mesenchymal stem cells by inhibiting inflammation through modulation of NF-κB/IκBα
Authors: Asadi Azita , Goudarzi Farjam , Ghanadian Mustafa , Mohammadalipour Adel 
Published: October 2022

Background and purpose:
Apigenin has stimulatory effects on osteogenic differentiation of human mesenchymal stem cells (hMSCs) as well as anti-inflammatory properties. This study investigated the osteogenic differentiation of hMSCs in inflammatory conditions treated with apigenin focusing on nuclear factor kappa-light-chain-enhancer of activated B (NF-кB), nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα) and nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammatory pathways.

Experimental approach:
Along with osteogenic differentiation of the hMSCs, they became inflamed with lipopolysaccharide (LPS)/palmitic acid (PA) and treated with apigenin. Alizarin red staining, alkaline phosphatase (ALP) activity, and Runt-related transcription factor 2 (RUNX2) gene expression were used to determine the degree of differentiation. Also, gene expression of NLRP3 was performed along with protein expression of interleukin 1-beta (IL-1β), NF-кB, and IκBα.

Findings / Results:
Apigenin was shown to be effective in neutralizing the inhibitory impact of LPS/PA on osteogenesis. Apigenin increased MSC osteogenic capacity by inhibiting NLRP3 expression and the activity of caspase-1. It was also associated with a considerable decrease in the protein expression of NF-κB and IκBα, as well as IL-1β, in these cells.

Conclusion and implications:
The effects of apigenin on osteogenesis under inflammatory conditions were cautiously observed.
Real-time ultrasound elastographic features and color doppler imaging of mitral valve prolapse
Authors: TOPAL Dursun , CAN Mehmet Erol , KARADAĞ TEKİN Evrim , UĞUZ Berat , KOCAMAZ Mehmet Fatih , ASLANCI Mehmet Emin 
Published: October 2022

Background: The aim of this study was to investigate the elasticity of ocular structures in patients with mitral valve prolapse (MVP).
Material and Methods: This prospective study included a total of 35 patients with MVP (study group) and 35 healthy volunteers (control group). The elastography value of the ratio of orbital fat- sclera (ROF/S) was measured with real-time US elastography. For each eye, central retinal artery (CRA), posterior ciliary artery (PCA), and ophthalmic artery (OA) were evaluated, respectively.
Results: The mean ages of the patients in the study and the control groups were 31.77 ± 11.40 years, and 30.65 ± 7.45 years, respectively (P =0.511). Mean ROF/S were 1.95 ± 0.81 and 1.37 ± 1.06 (P=0.001) in the study groups and control, respectively. The mean RI of the OA was 0.67 ± 0.05 in the control group, 0.67 ±0.05 (0.55; 0.87) in study group. The mean RI of the PCA was 0.66 ± 0.05 in the control group, 0.68 ±0.06 in study group. . The mean RI of the CRA was 0.66 ± 0.05 in the control group, 0.66 ±0.06 in study group. The RI value was not a significant difference between control and study group (p > 0.05).
Conclusion: Scleral elasticity was significantly increased in MVP patients. These could be related to ocular pathologies such as glacouma, kerataconus in MVP.
DISCURSO E AÇÃO: INTERCURSO DAS TECNOLOGIAS DIGITAIS NO TRABALHO DOCENTE EM ENSINO DE CIÊNCIAS
Authors: ROCHA CLAUDINO OSMUNDO , DE BARROS MARCELO 
Published: October 2022

"As plataformas digitais, tais como sites, aplicativos, jogos etc., permeiam as mais diversas atividades humanas no mundo contemporâneo. Este trabalho analisa as novas relações e a reestruturação da prática pedagógica a partir do impacto dessas tecnologias e da necessidade de inovações que colocam para professoras e professores. De tal modo, abordamos alguns conceitos e classificações das TIC, a repercussão no processo de ensino-aprendizagem, especificamente, focalizando o trabalho docente no ensino das ciências. A verificação empírica foi realizada através de questionário estruturado e envolveu a participação de professores atuantes em doze (12) escolas, entre públicas e particulares, situadas na área urbana do município de Campina Grande (PB). O levantamento revelou perfis professorais distintos, respectivamente, em escolas públicas e particulares. Nas primeiras, os docentes contam com longo tempo de vínculo com a unidade de trabalho e, em geral, são pós-graduados, enquanto que aquelas e aqueles que trabalham nas escolas particulares possuem menor tempo de vínculo e são graduados em tempo recente. Foram relatadas dificuldades importantes para o uso de softwares educacionais e aplicativos/jogos digitais, cujos problemas são compartilhados por profissionais de ambos os sistemas educacionais, contratando o amplo acesso às redes sociais com questões recorrentes como deficiências atribuídas à formação acadêmica e as deficiências de infraestrutura lógica e poucas oportunidades de capacitação para uso das tecnologias.	Um achado encorajador verificou-se no uso da rede social YouTube pela imensa maioria dos professores públicos e privados, ratificando o encantamento e a versatilidade acrescentados pela visualização e produção de vídeos educativos."
Alias le tireur d’or
Authors: Foa Jérémie 
Published: October 2022

L’article brosse le portrait d’un massacreur tout à la fois connu et méconnu de la Saint-Barthélemy : Thomas Croizier, peut-être l’un des pires bourreaux des matines parisiennes. Cette réflexion entreprend d’abord de penser la postérité de l’homme, largement cité par les historiens comme le « tireur d’or », cette étrange profession faisant écran à la connaissance de l’homme derrière le métier. Il s’agit ensuite de s’interroger sur le pourquoi et le comment des violences commises par Croizier. S’il est toujours délicat de reconstituer a posteriori les motivations idéologiques ou les croyances religieuses, on essaie de cerner le contexte intellectuel ou imaginaire dans lequel Croizier s’est mu. Plus faciles à cerner, les conditions qui ont permis à Croizier de devenir un tueur sont analysées – cadres vicinaux, professionnels, familiaux et amicaux. On ne naît pas tueur, on le devient. Enfin, parce que les bourreaux n’ont jamais été poursuivis, il s’agit de s’intéresser au devenir de Thomas Croizier après la Saint-Barthélemy.
La nouvelle et le massacre
Authors: Mingous Gautier 
Published: October 2022

Les « Saint-Barthélemy provinciales » ne peuvent se résumer en une simple imitation des massacres perpétrés à Paris à partir du 24 août 1572. Au-delà des logiques et des contextes propres à chaque ville, d’autres éléments sont à prendre en compte pour expliquer le basculement dans la violence. Parmi eux figure la question de l’information. À partir du cas Lyonnais, l’étude de la circulation des nouvelles liées aux tueries et de leur utilisation par les différents acteurs de la Saint-Barthélemy permet de saisir la complexité de la trame informationnelle de ces journées sanglantes, ainsi que la place prise par l’information dans le déclenchement et le déroulement des massacres. Rumeurs, fausses nouvelles, messages officieux comme officiels inondent la cité et favorisent une polyphonie confuse qui ouvre la voie aux tueries. L’étude de la Saint-Barthélemy par le prisme de l’information vient éclairer les mécanismes d’acceptation de la violence et pose la question de la place des nouvelles comme actrices des massacres.
INFLUENCE OF EROSION OF SOD-PODZOLIC SOILS ON THE PRODUCTIVITY OF AGRICULTURAL CROPS (RESULTS OF LONG-TERM FIELD EXPERIMENTS)
Authors: Tsybulka N. N. , Ustinova A. M. , Yukhnovets A. V. , Tsyrybkа V. B. , Kasyanenko I. I. , Voronovich S. D. 
Published: October 2022

Perennial leguminous grasses reduce yields on sod-podzolic slightly washed soils by an average of 14 % compared to non-eroded soils, on medium and heavily washed soils – by 20 and 25 % respectively. Depending on the developing hydrothermal conditions of the growing season, the decrease can reach 30 %. Under the same soil-geomorphological conditions, the alfalfa of the north reduces the yield to a greater extent
compared with the eastern galega and meadow clover.
Perennial legume-cereal grasses reduce yields on sod-podzolic medium-washed
soils by an average of 11 %, on heavily washed soils – by 19 %. Annual legume-cereal
grasses reduce yields on sod-podzolic slightly washed soils by an average of 10 %
compared to non-aerated soils, on medium and heavily washed soils – by 18 and 25 %
respectively. Annual grasses to a greater extent reduces the yield on sod-podzolic soils
on moraine loams compared to soils on loess-like loams.
Pelatihan Pembuatan Perangkat Pembelajaran Tematik Berbasis Karakter Bagi Guru Sekolah Dasar
Authors: Triaristinaa Aprilia , Sumargono Sumargono , Ekwandari Yustina Sri , Rachmedita Valensy 
Published: October 2022

Kegiatan pengabdian ini bertujuan untuk memberi pelatihan peyusunan perangkat pembelajaran tematik berbasis karakter. Sasaran dalam kegiatan ini adalah guru Sekolah dasar. Pelaksanaan kegiatan menggunakan metode Ceramah, Diskusi, Praktik, Self and Reflection. Kegiatan dilaksanakan melalui tahapan berikut, yaitu: Observasi awal permasalahan mitra, Penentuan solusi untuk mengatasi permasalahan mitra, Pretest awal pengetahuan dan kemampuan guru dalam menyusun perangkat pembelajaran tematik berbasis karakter, Pelatihan sesi pertama tentang pembelajaran berpendekatan karakter, Pelatihan sesi kedua tentang Pembelajaran yang menintegrasikan nilai nilai karakter, Pelatihan sesi ketiga praktek menyusun perangkat pembelajaran berpendekatan nilai-nilai karakter, Pelatihan sesi keempat implementasi perangkat pembelajaran berpendekatan nilai-nilai karakter, Post test dan evaluasi pelaksanaan pelatihan.
Ebelik Öğrencilerinin Aşı Ve Aşı Reddi İle İlgili Görüşlerinin İncelenmesi
Authors: DEMİREZEN Esma , TANRIVERDİ Fatma Şule 
Published: October 2022

Amaç: Bu çalışma ile ebelik birinci ve dördüncü sınıf öğrencilerinin aşı ve aşı reddi ile ilgili görüşlerinin incelenmesi amaçlanmıştır.
Yöntem: Kesitsel tanımlayıcı tipteki araştırma birinci ve dördüncü sınıf 286 ebelik öğrencileriyle ebelik bölümlerinde yürütülmüştür. Veriler literatür taranarak oluşturulan 18 soruluk anket ile alınmış ve SPSS 21.0 programında tanımlayıcı ve ilişki arayıcı analizler ile değerlendirilmiştir.
Bulgular: Öğrencilerin %92’sininaşıların koruyuculuğuna inanmaktadır. Ret nedenleri arasında %46,9 ilaç firmalarına karşı güvensizlik, %43,7 aşının zararlı içeriği, %39,5 doğal bağışıklığın daha güçlü olduğu gibi nedenler yer almıştır. Gelecekte aşı reddi ile karşılaşması durumunda %63,6’sı bilgilendirme yoluyla aşıya teşvik edeceklerini belirtmiştir. Sınıflara göre, aşı reddini bireysel hak olarak görme, yan etkilerin gizlendiği görüşü, aşı reddine saygı duyma, ret durumunda aydınlatılmış onam alma birinci sınıfta yüksek bulunurken (p
Jeanne Mammen
Authors: Smith Camilla 
Published: October 2022

Jeanne Mammen’s watercolour images of the gender-bending ‘new woman’ and her candid portrayals of Berlin’s thriving nightlife appeared in some of the most influential magazines of the Weimar Republic and are still considered characteristic of much of the ‘glitter’ of that era. This book charts how, once the Nazis came into power, Mammen instead created ‘degenerate’ paintings and collages, translated prohibited French literature and sculpted in clay and plaster—all while hidden away in her tiny studio apartment in the heart of Berlin’s fashionable west end.
What was it like as a woman artist to produce modern art in Nazi Germany? Can artworks that were never exhibited in public still make valid claims to protest? Camilla Smith examines a wide range of Mammen’s dissenting artworks, ranging from those created in solitude during inner emigration to her collaboration with artist cabarets after the Second World War. Smith's engaging analysis compares Mammen's popular Weimar work to her artistic activities under the radar after 1933, in order to fundamentally rethink the moral complexities of inner emigration and its visual culture. While Mammen’s artistry is considered through the lens of gender politics to reveal her complex relationship with the urbanisation of her time, this book also highlights the crucial role played by a lost generation of inner émigrés women artists as agents of German modernity.
The examination of Mammen’s life and work demonstrates the crucial role women artists played as both markers and agents of German modernity, but the double marginalisation they have nonetheless encountered as inner émigrés in recent history. It will be of interest to students of German studies, art history, literature, history, gender studies and cultural studies.
Economia da Informação na Indústria 4.0
Authors: Eurico Soares de Noronha Matheus , Silva Rosemeire , Gonçalves Sauer Paula , Bidin da Silva Priscilla 
Published: October 2022

Objetivos: O objetivo geral do ensaio é verificar de que forma a economia da informação se beneficia das ferramentas da Indústria 4.0. Os objetivos secundários são mapear as principais plataformas digitais utilizadas para a disseminação de informação industrial rapidamente e em larga escala e identificar as vantagens econômicas utilizadas por empresas dentro da indústria 4.0.
Metodologia/ abordagem: A instrumentalização de coleta de informações deste ensaio se deu a partir de um apanhado bibliográfico e referencial das áreas de (i) Economia da Informação, (ii) Indústria 4.0 e (iii) Digitalização empresarial.
Principais resultados: Os principais resultados demonstram que soluções como big data, data science e inteligência artificial podem corroborar ampliando os efeitos multiplicadores da Economia da Informação.
Contribuições teóricas e metodológicas: A contribuição teórica se dá por evidenciar para as pesquisas seminais, os fluxos informacionais estabelecidos nas novas plataformas de negócios contempladas na Indústria 4.0. Metodologicamente o ensaio contribui em trazer à luz novas perspectivas sobre como a economia da informação pode contribuir para o avanço da Indústria 4.0, explorando caminhos pouco pavimentados nas literaturas de ciências da informação, econômicas e sociais.
Relevância e originalidade: A relevância desse ensaio está em apontar plataformas que exercem soluções para economia da informação pavimentando o campo de estudo para análises posteriores. Também objetiva-se apresentar novas possibilidades de ferramentas teóricas para a Indústria 4.0 e enquadrar o fenômeno no campo de estudo da economia e administração.
Comparison of Sinus Tarsi and Extensile Lateral Approach in Intra-articular Calcaneus Fractures
Authors: GÜVEN Necip , ÖZKAN Sezai , GÜZEL Fatih , TÜRKÖZÜ Tülin , KAYA Şehmuz , TOKYAY Abbas 
Published: October 2022

Objective: In this study, we aimed to compare the clinical and radiological results of the extensile lateral (EL) approach and sinus tarsi (ST) approach in calcaneal fracture surgery.
Materyal-Metod: A total of 40 patients with Sanders II-III calcaneal fractures, including 22 patients in the EL group and 18 patients in the ST group, were included in this retrospective study. In the radiological evaluation, changes in the calcaneus Bohler and Gissane angle, length, width, and height were measured during the preoperative and postoperative period. Clinically, American Orthopedic Foot and Ankle Society (AOFAS) and the visual analog scale (VAS) were evaluated. In addition, postoperative complications were also evaluated.
Results: In terms of demographic data, the results of both groups were similar. Both the length of hospital stay and the time to surgery were shorter in the ST group (p=0.019, p=0.02, respectively). There was no significant difference between the groups regarding radiological, clinical AOFAS and VAS scores. 13.6% superficial infection was seen in the EL group, and no wound problems were encountered in the ST group (p=0.102). The rate of sural nerve injury was 36.4% in the EL group and 5.6% in the ST group (p =0.003).
Conclusion: Both approaches clinical and radiological outcomes were similar. However, the advantages of the ST approach were shorter hospital stays, lower rate wound infections, and sural nerve injury problems.
Pediatric Posterior Fossa Epidural Hematomas
Authors: GEZER Burak , KARAGOZ Ahmet Selim , ŞAHİNOĞLU Mert , KARABAĞLI Hakan 
Published: October 2022

Aim: Posterior fossa epidural hematoma (PFEDH) in the pediatric age group is a very rare condition and the treatment method is still a matter of debate. The aim of this study is to evaluate the observation results in the management of pediatric patients with PFEDH in our tertiary care hospital and to investigate the importance of the relationship of the hematoma with the cerebral venous sinuses, which has not been investigated before in the literature, in the treatment decision.
Materials and Methods: This is a retrospective study conducted at Selcuk University, Faculty of Medicine. All patients (≤ 17 years) diagnosed with PFEDH between January 2010 and May 2022 were included in this study. Demographic data, clinical signs, trauma type and symptoms at presentation, CT findings, type of treatment, and outcomes were collected. CT findings including hematoma thickness, hydrocephalus, presence of fourth ventricular compression, relation with cerebral venous sinuses and other associated brain injuries were evaluated.
Results: The patient group consists of two girl and six boy. The most common cause of PFEDH was a fall from a height resulting in a blow to the back of the head in four patients. Vomiting was the most frequent presenting symptom. Four patients had a relation between cerebral venous sinuses and hematoma, and two of these patients underwent surgical treatment
Conclusion: In addition to criteria such as hematoma thickness, GCS, hydrocephalus, and compression of the fourth ventricle, we determined that the relationship of hematoma with venous sinuses is a criterion to be evaluated.