bluuebunny/crossref_metadata_2025_split huggingface dataset:
FLOT Versus FLOT/Trastuzumab/Pertuzumab Perioperative Therapy of Human Epidermal Growth Factor Receptor 2–Positive Resectable Esophagogastric Adenocarcinoma: A Randomized Phase II Trial of the AIO EGA Study Group
Authors: Hofheinz Ralf-Dieter , Merx Kirsten , Haag Georg M. , Springfeld Christoph , Ettrich Thomas , Borchert Kersten , Kretzschmar Albrecht , Teschendorf Christian , Siegler Gabriele , Ebert Matthias P. , Goekkurt Eray , Mahlberg Rolf , Homann Nils , Pink Daniel , Bechstein Wolf , Reichardt Peter , Flach Hagen , Gaiser Timo , Battmann Achim , Oduncu Fuat S. , Loose Maria , Sookthai Disorn , Pauligk Claudia , Göetze Thorsten O. , Al-Batran Salah-Eddin 
Published: June 2022

PURPOSE High pathologic complete response (pCR) rates and comparably good survival data were seen in a phase II trial combining perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy with trastuzumab for resectable, esophagogastric adenocarcinoma (EGA). The current trial evaluates the addition of trastuzumab and pertuzumab to FLOT as perioperative treatment for human epidermal growth factor receptor 2–positive resectable EGA. METHODS In this multicenter, randomized phase II/III trial, patients with human epidermal growth factor receptor 2–positive, resectable EGA (≥ clinical tumor 2 or clinical nodal–positive) were assigned to four pre- and postoperative cycles of either FLOT alone (arm A) or combined with trastuzumab and pertuzumab, followed by nine cycles of trastuzumab/pertuzumab (arm B). The primary end point for the phase II part was the rate of pCR. RESULTS The trial was closed prematurely, without transition into phase III, after results of the JACOB trial were reported. Eighty-one patients were randomly assigned (A: 41/B: 40) during the phase II part. The pCR rate was significantly improved with the trastuzumab/pertuzumab treatment (A: 12%/B: 35%; P = .02). Similarly, the rate of pathologic lymph node negativity was higher with trastuzumab/pertuzumab (A: 39%/B: 68%), whereas the R0 resection rate (A: 90%/B: 93%) and surgical morbidity (A: 43%/B: 44%) were comparable. Moreover, the inhouse mortality was equal in both arms (overall 2.5%). The median disease-free survival was 26 months in arm A and not yet reached in arm B (hazard ratio, 0.58; P = .14). After a median follow-up of 22 months, the median overall survival was not yet reached (hazard ratio, 0.56; P = .24). Disease-free survival and overall survival rates at 24 months were 54% (95% CI, 38 to 71) and 77% (95% CI, 63 to 90) in arm A and 70% (95% CI, 55 to 85) and 84% (95% CI, 72 to 96) in arm B, respectively. More ≥ grade 3 adverse events were reported with trastuzumab/pertuzumab, especially diarrhea (A: 5%/B: 41%) and leukopenia (A: 13%/B: 23%). CONCLUSION The addition of trastuzumab/pertuzumab to perioperative FLOT significantly improved pCR and nodal negativity rates at the price of higher rates of diarrhea and leukopenia.
A decade of time crystals: Quo vadis?
Authors: Hannaford Peter , Sacha Krzysztof 
Published: June 2022

Abstract
Ten years ago, the new era of time crystals began. Time crystals are systems that behave in the time dimension like ordinary space crystals do in space dimensions. We present a brief history of a decade of research on time crystals, describe current research directions, indicate challenges, and discuss some future perspectives for condensed matter physics in the time domain.
Generating spatiotemporal patterns of linearly polarised light at high frame rates for insect vision research
Authors: Supple Jack A. , Varennes-Phillit Léandre , Gajjar-Reid Dexter , Cerkvenik Uroš , Belušič Gregor , Krapp Holger G. 
Published: June 2022

ABSTRACT
Polarisation vision is commonplace among invertebrates; however, most experiments focus on determining behavioural and/or neurophysiological responses to static polarised light sources rather than moving patterns of polarised light. To address the latter, we designed a polarisation stimulation device based on superimposing polarised and non-polarised images from two projectors, which can display moving patterns at frame rates exceeding invertebrate flicker fusion frequencies. A linear polariser fitted to one projector enables moving patterns of polarised light to be displayed, whilst the other projector contributes arbitrary intensities of non-polarised light to yield moving patterns with a defined polarisation and intensity contrast. To test the device, we measured receptive fields of polarisation-sensitive Argynnis paphia butterfly photoreceptors for both non-polarised and polarised light. We then measured local motion sensitivities of the optic flow-sensitive lobula plate tangential cell H1 in Calliphora vicina blowflies under both polarised and non-polarised light, finding no polarisation sensitivity in this neuron.
Case Report: Paraquat poisoning
Authors: Sigdel Keshav Raj , Bhattarai Saraswati , Thapa Astha , Dahal Agnimshwor , Adhikari Sudeep , Panthi Ram Chandra , Lama Mipsang , Paudyal Buddhi , Basnyat Buddha 
Published: June 2022

Paraquat (1, 1′-dimethyl-4,4′-bipyridinium) is a commonly used herbicide that is highly toxic when ingested. Ingestion of toxic doses of paraquat has serious complications on the lungs, gastrointestinal tract, kidney, liver, and other organs. Due to its inherent toxicity and the lack of a specific antidote, it has a high case fatality rate. Despite being restricted to commercially licensed users in Nepal, it is a common herbicide causing both intentional and accidental poisoning. Although there have been numerous anecdotal cases of paraquat poisoning in Nepal, no reports have been published in the literature. . We report a case of a 30-year old female, who developed gastrointestinal symptoms like vomiting, diarrhoea and odynophagia, renal and liver injury after accidental ingestion of 10ml of 20% paraquat. Symptoms and organ involvement subsided with timely and appropriate supportive management.
A Closest Benders Cut Selection Scheme for Accelerating the Benders Decomposition Algorithm
Authors: Seo Kiho , Joung Seulgi , Lee Chungmok , Park Sungsoo 
Published: June 2022

The Benders decomposition algorithm often shows poor convergence. To improve the convergence of the Benders decomposition algorithm. Recently, it was proposed the use of feasibility cuts closest to a solution in the set defined by all feasibility cuts. We extend this feasibility cut selection scheme to a new cut selection scheme for optimality cuts and propose a new Benders separation framework that a single linear programming problem can solve. We show that optimality cuts generated by this scheme are Pareto optimal when some conditions are satisfied. Theoretical connections to the existing Benders cut generation methods are also identified. Extensive computational experiments on the multiple classes of benchmark problems demonstrate that the proposed algorithm improves the convergence speed and computational time. Summary of Contribution: The Benders decomposition algorithm is one of the most widely used algorithms in operations research. However, the Benders decomposition algorithm often shows poor convergence for some optimization problems. In this paper, to improve the convergence of the Benders decomposition algorithm, we propose a unified closest Benders cut generation scheme. We give theoretical properties of the proposed Benders cuts, including Pareto optimality and facet-defining conditions. Also, we conducted extensive computational tests on various instances, such as network design and expansion problems. The results show the effectiveness of the closest Benders cut compared with existing algorithms and Cplex.
Analysis of mortality metrics associated with a comprehensive range of disorders in Denmark, 2000 to 2018: A population-based cohort study
Authors: Plana-Ripoll Oleguer , Dreier Julie W. , Momen Natalie C. , Prior Anders , Weye Nanna , Mortensen Preben Bo , Pedersen Carsten B. , Iburg Kim Moesgaard , Christensen Maria Klitgaard , Laursen Thomas Munk , Agerbo Esben , Pedersen Marianne G. , Brandt Jørgen , Frohn Lise Marie , Geels Camilla , Christensen Jesper H. , McGrath John J. 
Published: June 2022

Background
The provision of different types of mortality metrics (e.g., mortality rate ratios [MRRs] and life expectancy) allows the research community to access a more informative set of health metrics. The aim of this study was to provide a panel of mortality metrics associated with a comprehensive range of disorders and to design a web page to visualize all results.

Methods and findings
In a population-based cohort of all 7,378,598 persons living in Denmark at some point between 2000 and 2018, we identified individuals diagnosed at hospitals with 1,803 specific categories of disorders through the International Classification of Diseases-10th Revision (ICD-10) in the National Patient Register. Information on date and cause of death was obtained from the Registry of Causes of Death. For each of the disorders, a panel of epidemiological and mortality metrics was estimated, including incidence rates, age-of-onset distributions, MRRs, and differences in life expectancy (estimated as life years lost [LYLs]). Additionally, we examined models that adjusted for measures of air pollution to explore potential associations with MRRs. We focus on 39 general medical conditions to simplify the presentation of results, which cover 10 broad categories: circulatory, endocrine, pulmonary, gastrointestinal, urogenital, musculoskeletal, hematologic, mental, and neurologic conditions and cancer. A total of 3,676,694 males and 3,701,904 females were followed up for 101.7 million person-years. During the 19-year follow-up period, 1,034,273 persons (14.0%) died. For 37 of the 39 selected medical conditions, mortality rates were larger and life expectancy shorter compared to the Danish general population. For these 37 disorders, MRRs ranged from 1.09 (95% confidence interval [CI]: 1.09 to 1.10) for vision problems to 7.85 (7.77 to 7.93) for chronic liver disease, while LYLs ranged from 0.31 (0.14 to 0.47) years (approximately 16 weeks) for allergy to 17.05 (16.95 to 17.15) years for chronic liver disease. Adjustment for air pollution had very little impact on the estimates; however, a limitation of the study is the possibility that the association between the different disorders and mortality could be explained by other underlying factors associated with both the disorder and mortality.

Conclusions
In this study, we show estimates of incidence, age of onset, age of death, and mortality metrics (both MRRs and LYLs) for a comprehensive range of disorders. The interactive data visualization site (https://nbepi.com/atlas) allows more fine-grained analysis of the link between a range of disorders and key mortality estimates.
Risk factors associated with tuberculosis recurrence in South Korea determined using a nationwide cohort study
Authors: Youn Hin Moi , Shin Moon-Kyung , Jeong Dawoon , Kim Hee-Jin , Choi Hongjo , Kang Young Ae 
Published: June 2022

Objective
Prevention of tuberculosis (TB) recurrence is an important issue in TB control. South Korea, a country with a high average income, has been challenged with an intermediate burden of TB. We aimed to estimate the TB recurrence rate after successful completion of the first anti-TB chemotherapy, and to identify the risk factors for the TB recurrence by focusing on co-morbidities and behavioral factors.

Methods
This is a population-based cohort study using data from the National Health Insurance (NHI) database between 2002 and 2013. Newly diagnosed TB patients were identified using the classification of disease codes and prescription records. Final analytical subjects included people who successfully completed the first anti-TB chemotherapy. The primary outcome measure was recurrent TB 6-month after the first treatment completion. A set of associated risk factors, including demographic characteristics, co-morbidities, and health behavior factors were analyzed using Cox regression analysis.

Results
Among 5,446 TB patients, 2,226 (40.1%) completed the first anti-TB treatment. During the follow-up period, 150 (6.7%) patients had TB recurrence, and the crude recurrent rate was 22.6 per 1000 person-years. The majority of recurrence cases (89%) occurred within the first 2-year period. The major findings show that participants who are male (adjusted HR (aHR) = 1.81, at a 95% CI, range: 1.11–2.94), older in age (aHR = 1.07, at a 95% CI, range: 1.00–1.14), have a lower income (aHR = 1.96, at a 95% CI, range: 1.10–3.48) and who are underweight (aHR = 1.92, at a 95% CI, range 1.15–3.20) were at higher risks for TB recurrence.

Conclusion
People who have risk factors for recurrent TB need to improve treatment compliance through more effective TB management, and follow-up observation for one or two years after the treatment completion.
Irrational prescription of surfactant replacement therapy in neonatal respiratory distress
Authors: Jahanmehr Nader , Izadi Reyhane , Habibolahi Abbas , Yousefzadeh Setareh , Khodakarim Soheila 
Published: June 2022

Purpose
Respiratory distress is known as one of the leading causes of neonatal death. In recent decades, surfactant therapy has revolutionized respiratory failure. Since the implementation of the health system reform plan as well as the allocation of new financial resources for health system in Iran, the rate of irrational prescription has increased and prescription of surfactant for neonates, has raised unexpectedly, which is thought to be due to irrational prescriptions partly. The present study aimed to determine the rate of irrational prescription of surfactant for neonates with respiratory distress.

Methods
This research was a cross-sectional descriptive study, which was conducted retrospectively. In the current study, determining the rate of irrational prescription was done in terms of the surfactant prescription guideline. Finally, the medical data of 846 neonates who underwent surfactant therapy in Iran in 2018, were extracted from the information system of the Ministry of Health and the neonatal medical records.

Results
The results show that drug selection index, dose index, and time index were irrational for 14.30%, 27.42%, and 1.06% of neonates, respectively. Moreover, the total index of drug prescription, which is a combination of the above-mentioned three components, was found to be irrational for 31.47% of neonates.

Conclusions
The results of the present study are considered as a warning to providers and decision makers in the field of neonatal health to reduce irrational prescriptions of surfactant for neonates. This study suggests the use of educational interventions in order to reduce irrational prescriptions due to drug selection as well as the use of computer alert approaches in order to reduce irrational prescriptions due to wrong dose.
Evidence-based service delivery interventions for testing, linking, treating, and retaining children and adolescents living with HIV in primary health care settings: Protocol for a systematic review
Authors: Putta Nande , Hansen Caitlin E. , Funaro Melissa C. , Campbell Melissa , Essajee Shaffiq , Mbori-Ngacha Dorothy , Frimpong Shadrack , Wang Shi-Yi , Paintsil Elijah 
Published: June 2022

Background
At the end of 2019, there were about 2.8 million children and adolescents aged 0–19 living with HIV. In contrast to pregnant women and adults, service delivery for children and adolescents living with HIV continues to lag behind with regard to access to care, components of care delivery, treatment options, and clinical and immunologic outcomes.

Aim
The aim of this systematic review is to synthesize the evidence on the most effective interventions, models, programs, and strategies to optimize the delivery of services for the testing, linkage, treatment and retention of children and adolescents living with HIV globally.

Methods
This review protocol is registered at PROSPERO with Registration number: CRD42020209553. The systematic review will be conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P). We will use a comprehensive search strategy to search several bibliographic databases including MEDLINE, Embase, CINAHL, Cochrane Library, Global Health, and Psycinfo to identify relevant studies published in the last ten years (2010 to 2020). In addition, we will review cited and citing references of included studies. A pair of reviewers will independently screen titles, abstracts and full texts of articles, extract data from articles meeting inclusion criteria and perform quality assessments of the evidence collected. We will conduct a narrative synthesis of our findings, and if there are sufficient clinically similar studies available, we will conduct meta-analysis using a random-effects model.

Discussion
This review will provide evidence on service delivery models that have been evaluated in a range of settings to efficiently and effectively locate, link, treat and retain in care, children and adolescents living with HIV. The synthesized evidence will help guide national governments and health care providers in prioritizing and adopting evidence-based service delivery approaches for children and adolescents living with HIV.

Systematic review registration
PROSPERO CRD42020209553.
Impact of the suboptimal communication network environment on telerobotic surgery performance and surgeon fatigue
Authors: Akasaka Harue , Hakamada Kenichi , Morohashi Hajime , Kanno Takahiro , Kawashima Kenji , Ebihara Yuma , Oki Eiji , Hirano Satoshi , Mori Masaki 
Published: June 2022

Background
Remote surgery social implementation necessitates achieving low latency and highly reliable video/operation signal transmission over economical commercial networks. However, with commercial lines, communication bandwidth often fluctuates with network congestion and interference from narrowband lines acting as bottlenecks. Therefore, verifying the effects on surgical performance and surgeon fatigue when communication lines dip below required bandwidths are important.

Objectives
To clarify the communication bandwidth environment effects on image transmission and operability when bandwidth is lower than surgical robot requirements, and to determine surgeon fatigue levels in suboptimal environments.

Methods
Employing a newly developed surgical robot, a commercial IP-VPN line connected two hospitals 150 km apart. Thirteen surgical residents remotely performed a defined suturing procedure at 1-Gbps to 3-Mbps bandwidths. Communication delay, packet loss, time-to-task completion, forceps-movement distance, video degradation, and robot operability were evaluated before and after bandwidth changes. The Piper Fatigue Score-12 (PFS-12) was used to measure fatigue associated with surgeon performance.

Results
Roundtrip communication time for both 1-Gbps and 3-Mbps lines averaged 4 ms. Video transmission delay from camera to monitor was comparable, at 92 ms. Surgical robot signal transmission rate averaged 5.2 Mbps, so changing to 1-Gbps-3-Mbps lines resulted in significant packet loss. Surgeons perceived significant roughness, image distortion, diplopia, and degradation of 3D images (p = 0.009), but not changes in delay time or maneuverability. All surgeons could complete tasks, but objective measurement of task-completion time and forceps-travel distance were significantly prolonged (p = 0.013, p = 0,041). Additionally, PFS-12 showed post-procedure fatigue increase at both 1-Gbps and 3-Mbps. Fatigue increase was significant at 3-Mbps (p = 0.041).

Conclusions
In remote surgery environments with less than the optimal bandwidth, even when delay time and operability are equivalent, reduced surgical performance occurs from video degradation from packet loss. This may cause increased surgeon fatigue.
The optimal dynamic treatment rule superlearner: considerations, performance, and application to criminal justice interventions
Authors: Montoya Lina M. , van der Laan Mark J. , Luedtke Alexander R. , Skeem Jennifer L. , Coyle Jeremy R. , Petersen Maya L. 
Published: June 2022

Abstract
The optimal dynamic treatment rule (ODTR) framework offers an approach for understanding which kinds of patients respond best to specific treatments – in other words, treatment effect heterogeneity. Recently, there has been a proliferation of methods for estimating the ODTR. One such method is an extension of the SuperLearner algorithm – an ensemble method to optimally combine candidate algorithms extensively used in prediction problems – to ODTRs. Following the ``causal roadmap,” we causally and statistically define the ODTR and provide an introduction to estimating it using the ODTR SuperLearner. Additionally, we highlight practical choices when implementing the algorithm, including choice of candidate algorithms, metalearners to combine the candidates, and risk functions to select the best combination of algorithms. Using simulations, we illustrate how estimating the ODTR using this SuperLearner approach can uncover treatment effect heterogeneity more effectively than traditional approaches based on fitting a parametric regression of the outcome on the treatment, covariates and treatment-covariate interactions. We investigate the implications of choices in implementing an ODTR SuperLearner at various sample sizes. Our results show the advantages of: (1) including a combination of both flexible machine learning algorithms and simple parametric estimators in the library of candidate algorithms; (2) using an ensemble metalearner to combine candidates rather than selecting only the best-performing candidate; (3) using the mean outcome under the rule as a risk function. Finally, we apply the ODTR SuperLearner to the ``Interventions” study, an ongoing randomized controlled trial, to identify which justice-involved adults with mental illness benefit most from cognitive behavioral therapy to reduce criminal re-offending.
Convex optimization for additive noise reduction in quantitative complex object wave retrieval using compressive off-axis digital holographic imaging
Authors: Reddy B. Lokesh , Nelleri Anith 
Published: June 2022

Abstract
Image denoising is one of the important problems in the research field of computer vision, artificial intelligence, 3D vision, and image processing, where the fundamental aim is to recover the original image features from a noisy contaminated image. The camera sensor additive noise present in the holographic recording process reduces the quality of the retrieved image. Even though various techniques have been developed to minimize the noise in digital holography, the noise reduction still remains a challenging task. This article presents a compressive sensing (CS) technique to minimize the additive noise in the digital holographic reconstruction process. We demonstrate the reduction of additive noise using complex wave retrieval method as a sensing matrix in the CS model. The proposed CS method to suppress the noise during the reconstruction process is illustrated using numerical simulations. Only 50% of the pixel measurements are considered in the noisy hologram, which is far less than the original complex object pixels. The impact of additive gaussian noise in the recording plane on the reconstruction accuracy of both intensity and phase distribution is analysed. The CS method denoises and estimates the complex object information accurately. The numerical simulation results have shown that the proposed CS method has effectively minimized the noise in the reconstructed image and has greatly improved the quality of both intensity and phase information.