bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application and algorithmic software of the control system of the technical state parameters of the two-stage centrifugal compressor
Authors: Harasymiv V. M. , Moiseenko O. V. , Harasymiv T. G. 
Published: March 2022

Efficiency of the technical state of the compressor station basic components depends on the timely prediction of the appearance of damages. It is defined by the estimation of the technical state of the basic components during the compression process. It is known that the two-stage centrifugal compressors are commonly used in the Ukrainian compressor stations. So, application software and algorithm for the two-stage centrifugal compressor have been developed, what allows to define its technical state parameters, taking into account the construction features of the compressor volute.
The algorithm of the control system of the technical state parameters for the two-stage centrifugal compressor has been represented, what allows to define the receiving of the information order from sensors, methods of the information analysis and the representing order of the information to the operator.
Application software for the control system of the technical state parameters of the two-stage centrifugal compressor has been organized like the application program module to aim to analyze and define the technical state of the two-stage centrifugal compressor during the compression process. It was written in the object-oriented language Delphi, and with the opportunity of its integration into existing software for conrolling the compressor. The software provides the capability of data collection and processing, the mathematical model parameters identification of the centrifugal compressor, determining volumetric productivity values, which correspond to the conditions where the centrifugal compressor is a new one or after its overhaul, calculating technical state parameters of the compressor and the expert estimation of the volute technical state of the two-stage centrifugal compressor based on fuzzy logic.
Application software for the parameters control of the two-stage centrifugal compressor has been tested during operation of the two-stage centrifugal compressor 650-21-2 of the compressor station 39 of Bogorodchany linear production administration of gas transmittal pipelines. Obtained results confirmed the average deterioration of the volute technical state.
Analysis of growth drive breakdown by the increase of the Dashav UGS fountain pipes
Authors: Chernova O. T. , Gershun B. I. 
Published: March 2022

Scientists who were analyzing the results of the underground gas storage (UGS) complex of Ukraine, say that for modern conditions the maximum daily productivity should be increased by 30-35%. Since the beginning of the creation of gas storage facilities passed than 40 years, work is carried on outdated and physically worn out equipment. Work of the wells (which were build based on the old technologies at low reservoir pressure) are characterized by low productivity because their bottomhole zone is partially occluded by the mud filtrate, partially contaminated with compressor oil; due to the selective placement of wells in the underground storage area, some of them were formed so-called "stagnant" zones; extraction of all active gas volume which takes 100-180 days. Need for Ukraine to further develop underground gas storage should be aimed at increasing both the active volume of gas and the daily productivity of gas storage facilities.
The main directions of increasing the productivity of gas storage are the drilling of horizontal shafts in both new wells and old ones in experience [9], the formation of open holes in the drilling of new wells and the milling of operational columns in the "old" drilled holes, filters, hydraulic fracturing, construction of large diameter wells, additional perforation of gas-saturated intervals.
Nowadays, the most important problem is the reconstruction and modernization of existing underground storage facilities through replacement of equipment. This will not only save the achieved performance, but also can improve it. Due to the reconstruction of the equipment, gas preparation will be improved, gas storage capacity will be increased and operating costs will be reduced. Therefore, an increase in the daily productivity of UGS can be achieved, first of all, due to the improvement of the main element in the gas storage facility - the operational well.
In order to analyze this issue, the paper analyzes the efficiency of replacing the fountain pipes of the Dashavsky UGS wells with a larger diameter, and presents the results of the hydraulic, technical and economic calculation of the implementation of this UGS reconstruction.
ALGORITHM OF ADJUSTMENT OF SUB-REGULATOR COEFFICIENTS WITH FUZZY LOGIC METHODS USING
Authors: Garasumiv V. M. 
Published: March 2022

The fuzzy PID tuning algorithm of proportional, integral, and derivative terms based on the fuzzy logic has been developed in the article. The fuzzy logic focuses on logic-linguistic models of representation of knowledges and it is the effective technology for creation of intellectual control systems of complex dynamic objects in the incomplete conditions.
It has been researched that the fuzzy tuning algorithm of the basic coefficients for the PID controller сompared with the tuning algorithm based on the trial and error method, improved the quality of the of the transient process, namely reduces the overshoot and the settling time. Another advantage of the fuzzy PID tuning algorithm is that the PID controller coefficients can change their values ​​in accordance with changing conditions of operation control object, which improves the adaptive properties of the automatic control system.
The structure of the automatic control system based on the fuzzy PID controller has been developed, the main components of which are the fuzzy PID controller and the transfer function of the control object. The fuzzy PID controller consists of the following main components: the fazzyfication unit, the rule base and the defazzyfication unit. This structure of the automatic control system does not require special means of identifying the parameters of the turboshaft engine and its implementation using modern microcontrollers is quite simple and affordable.
The fuzzy PID tuning algorithm has been tested with using the parameters of the turboshaft engine ДГ90Л2 with power 16MW of the compressor 16 ГЦ2-395/53-76С of Dolyna linear production administration of gas transmittal pipelines.
THE COMPUTER SYSTEM FOR OPTIMAL CONTROL OF NATURAL GAS PUMPING UNITS
Authors: Gorbijchuk M. I. , Lazoriv O. T. , Lazoriv A. M. 
Published: March 2022

Method of the optimal control of the natural gas compression process by a compressor station, which is equipped with gas pumping units with a gas turbine drive, has been developed.
The parallel scheme of connection of gas pumping units working on the general collector is considered.
The cost of fuel gas taking into account the power of nitrogen oxide emissions into the atmosphere is chosen as the criterion of optimality. This takes into account the restrictions on technological parameters and the planned task for the transportation of natural gas.
The formed problem is divided into two subtasks - the choice of the optimal number of parallel units in each of the subgroups and determining the optimal mode of operation of each unit in the group.
Formalization of optimal control problem of GPA operation takes into account the uncertainty inherent in the process of natural gas compression. For this purpose, the apparatus of fuzzy algebra was used, which made it possible to take into account the inaccuracies that arise both as a result of measuring technological parameters and as a result of processing the obtained data on the technological process.
The optimal control system is integrated into the upper level (dispatcher) and is an integral part of the overall control system of the GPA and has a hierarchical structure. At the lower level there are measuring devices of technological parameters, which are a source of information for the upper level where the solution of optimization problems takes place.
The developed methods formed the basis of the algorithmic and software of the computer system for optimal control of a separate unit of the compressor station, which can be integrated into the existing automated system.
واقع التعليم المدمج في الجامعات العربية "دراسة حالة على طلبة جامعة الشارقة في دولة الامارات العربية المتحدة وطلبة جامعة حائل في المملكة العربية السعودية"
Authors: Barhoumi Wafa Omar 
Published: March 2022

تهدف هذه الدراسة إلى التعرف على تصورات طلبة كلية الآداب والعلوم الإنسانية والاجتماعية فيما يتعلق بأهمية واستخدام التعلم المدمج في جامعة الشارقة في الإمارات العربية المتحدة وجامعة حائل بالمملكة العربية السعودية. كما تحاول هذه الدراسة معرفة إلى أي مدى تتوفر المعدات والأدوات اللازمة لتطبيق التعلم المدمج، وكذلك ما هي عوائق استخدام التعلم المدمج في التدريس. اعتمدت هذه الدراسة المنهج الوصفي. يتم إرسال استبيان إلى 200 طالب في كل جامعة. يتم تحليل البيانات كمياً باستخدام الحزمة الإحصائية للعلوم الاجتماعية (SPSS). تم عرض البيانات الوصفية بما في ذلك النسب المئوية والمتوسطات. وأظهرت النتائج أن هناك اتفاقًا كبيرًا بين طلبة جامعة الشارقة وجامعة حائل على أهمية الاستفادة من التعلم المدمج. ومع ذلك، يوافق جميع المشاركين إلى حد ما على أنه يتم استخدامه حاليًا. كما أظهرت النتائج أيضًا أنه في حين أن هناك درجة معتدلة من الاتفاق بين الطلبة على توفر المعدات والمواد اللازمة لتنفيذ التعلم المدمج، إلا أن هناك درجة منخفضة من الاتفاق بين الطلبة فيما يتعلق بهذه المشكلة. بالإضافة إلى ذلك، بينما يعتقد الطلبة إلى حد كبير أن هناك عقبات أمام الاستفادة من التعلم المدمج في الجامعات. أظهرت النتائج عدم وجود فروق بين استجابات عينة الدراسة فيما يتعلق بأهمية الاستفادة من التعلم المدمج، والأجهزة المستخدمة لتنفيذه، وكذلك معوقات الاستفادة منه.
وبناءً على نتائج الدراسة توصي الباحثة بما يلي:
1 - تطوير المنهج الحالي لتلبية متطلبات التعلم المدمج. يتم ذلك من خلال تشكيل لجنة مكونة من متخصصين في مجالات التعليم والحاسوب.
2 - توفير وتشغيل برامج تدريبية للمعلمين والطلاب على استخدام الحاسب الآلي والإنترنت.
3 - تقديم الدعم الفني المستمر للشبكة وصيانتها.
Decision-making regulatory framework of the introduction of health technologies at the hospitals in Ukraine
Authors: Філінюк О. М. , Алешко Д. В. , Бабенко М. М. , Косяченко К. Л. , Кахвечі Р. 
Published: March 2022

The limited resources of the health care system and the COVID-19 pandemic encourage more rational and cost-effective administrative and clinical decisions. To achieve the best health care within available resources, the introduction of the most efficient technologies should be supported, considering organizational, social and ethical issues. Assessment of health technologies at different levels, namely national/regional and hospital, is becoming increasingly important. Adherence to cost-effective approaches to administrative and clinical decision-making will ensure the rational use of the state budget and improve clinical outcomes, improve the quality and life expectancy of patients.
The purpose of the study was to analyze the current regulatory framework for the introduction of health technologies (medicines and medical devices) at the hospital level. During the research the methods of content analysis, historical, system-analytical, generalization was used.
According to the analysis of the decision-making regulatory framework for the health technology’s introduction, it was drawn the next conclusions. The active HTA development in Ukraine is noted. In a short time, a legal framework for state HTA for medicines was created and approved, amendments were made to the Law of Ukraine ‘On Public Procurement’ and other Ukraine’s laws on medicine procurement under managed entry agreements, the further steps for development of the HTA ecosystem in Ukraine were identified.
The legal framework for the circulation of medical devices needs to be updated in Ukraine, starting with technical regulations in accordance with EU regulations №745 and №746 and further approval of the Law on Medical Devices.
Procedures for evaluation and selection of medicines and medical devices at the level of medical institutions are absent in Ukraine and require separate elaboration. The introduction of HB-HTA will help hospital managers to make independent, transparent, reasonable, and impartial management decisions on the selection of drugs and medical devices.
The obtained results prove the need for further research of everyday decision-making practices on the introduction of health technologies at the hospitals, development of methodology for hospital-based HTA and update regulation of HB-HTA in the current legal framework of Ukraine.
Analysis of the assortment of antibiotics in the State Medicines Formulary according to the WHO AWaRe classification with the purpose of their rational use and reducing the risk of antimicrobial resistance
Authors: Яковлєва Л. В. , Романенко І. М. 
Published: March 2022

Rational use of antimicrobials have been recognized as one of the strategies to fight AMR. In 2017 WHO proposed the classification of antibioticsAWaRe, dividing them into groups Access, Watch, Reserve, which takes into account the potential of AMR and emphasizes the importance of rational antibiotic therapy. In Ukraine, the State Formulary of Medicines (State Formulary of Ukraine) is the manual on the rational use of medicines.
The aim of the work was to analyse the assortment of systemic antibiotics (J01) of the State Formulary of Ukraine, their compliance with the classification of antibiotics AWaRe according to the WHO database, which will contribute to rational antibiotic therapy.
The objects of the study were antibiotics (J01), of the 13th version of the State Formulary of Ukraine, data on the belonging of antibiotics to the group Access, Observations, Reserve on WHO AWaRe antibiotic classification database.The following research methods were used in the work: system-review, analytical, method of comparison and generalization.
According to the analysis, the group Access includes 23 INN antibiotics (J01) of the State Formulary of Ukraine. For 16 INNs of these antibioticsWHO provides recommendations for rational antibiotic therapy as the first choice for 31 infectious diseases and the second choice for 13 infectious diseases. The Observations group includes 31 INN antibiotics (J01) of the State Formulary of Ukraine. For 18 INNs of these antibiotics WHO provides recommendations for rational antibiotic therapy as the first choice for 21 infectious diseases and the second choice for 17 infectious diseases. The Reserve group includes 3 INN antibiotics (J01) of the State Formulary of Ukraine.
The State Formulary of Ukraine includes 64 INN antibiotics of systemic action (J01), 23 INNs according to the WHO AWaRe antibiotic classification are assigned to the group Access, 31 ‒ Observations and 3 ‒ Reserve group. The analysis provides WHO recommendations for rational antibiotic therapy for the treatment of common infectious diseases, taking into account the degree of counteraction to the development of AMR. The results of the work can be used in the development of guidelines for the rational choice of antibiotics for the treatment of infectious diseases.
Analysis of the epidemiological state of mental disorders and pharmaceutical provision of patients with medicines by the government of Ukraine.
Authors: Немченко А. С. , Ляденко А. В. 
Published: March 2022

The number of patients with mental disorders is growing every year, which has a significant impact on the increase in cases of disability and loss of one of the five years of healthy life. In Ukraine, the incidence of depressive disorders and disorders caused by alcohol consumption exceeds that of Eastern Europe. The COVID-2019 global pandemic has affected the rapid spread of new cases of depressive disorders (53.2 million or 27.6%) and anxiety disorders (76.2 million or 25.6%) in 2020. These trends in Ukraine and the world have led to changes in the formation and implementation of the National Mental Health Policy, as most disorders are successfully treated with access to medicine and availability of medicines for patients.
The aim of the work was to assess the current state of morbidity and prevalence of mental disorders in Ukraine and the world, as well as to analyse the access of medicines for patients according to current government programs.
The objectі of the study were the data of the Center for Mental Health and Monitoring of Drugs and Alcohol of the Ministry of Health of Ukraine, regulations documents, analytical reports, international websites. The study used methods of analysis, systematization, generalization, analytical and graphical.
The study found an annual increase in outpatient mental health care and a sharp decline in inpatient and day care. Depressive disorders show a growth trend of 6.25% in Ukraine for the period 2018–2020, for comparison – only in 2020 in the world such growth was 27.6%. Analysis of medical practice shows that most mental disorders are not diagnosed as special cases, and are treated as concomitant diseases, which significantly affects the incidence and prevalence and as a consequence of the formation of government programs to provide patients with vital medicines in outpatient treatment.
The provision of drugs to patients on an outpatient basis today occurs according to the list of diseases defined by the Resolution of the Cabinet of Ministers of Ukraine No. 1303. Since October 1, the program of reimbursement of medicine for 9 INN has been expanded, which allowed patients with mental disorders to receive medicines free of charge or with a surcharge, without reference to their location.
The study revealed negative trends in the incidence and prevalence of mental disorders in Ukraine as a whole and in regions compared to similar indicators in the world, as well as identify key issues affecting the formation of government programs to provide patients with basic medicines.
Development and optimization of quantitative composition of rectal suppositories with diosmin and hesperidin by the method of mathematical planning of the experiment
Authors: Борко Є. А. , Ковалевська І. В. , Рубан О. А. , Кутова О. В. 
Published: March 2022

In the development of suppositories biphasic media are rarely used. It is due to the occurrence of possible instabilities within the system «dispersed phase and a dispersing medium». To solve such problems, it is rational to use the methods of mathematical planning of the experiment. The method of mathematical planning of the experiment feature is the diversity of approaches to model construction. This means that these methods are theoretically predict the results of a future experiment, analyze the data obtained, prevent the repetition of experiments and optimize the technology of medicine.
The aim of the present research was to develop and optimize of quantitative composition of rectal suppositories with diosmin and hesperidin by the method of mathematical planning of experiment.
Objects of the study were samples of suppositories of the biphasic type with diosmin and hesperidin. The dispersing medium of these samples consisted of hydrophobic (Witepsol W35 and emulsifiers) and hydrophilic parts (sodium alginate gel with the addition of Ca2+ as a complexing cation). Preliminary results of determining the percentage limits of the hydrophobic part of the dispersed medium were carried out by studying the indicators of the release of active substances from the dosage form and the laser diffraction method. As responses of experiments was used such indicator as: disintegration time, hardness and mucoadhesion.
As a result of the studies, the functional dependence of the indicators on the amount of components of the suppository dispersed medium was established. It was found that acceptable values of the responses should conform to the following conditions: hardness and mucoadhesion should be close to the maximum, and the disintegration time – to the minimum.
According to the results of the study it was found that the optimal content of the mixture of emulsifiers – 6.29%, solid fat – 39.51%, the hydrophilic part of the biphasic medium – 29.58%. Responses that will provide the system with the necessary structural-mechanical and pharmaco-technological properties are within: y1 (2.713); y2 (22.639); y3 (439.283). The obtained data will be used in further studies to optimize the composition and technology of rectal suppositories with diosmin and hesperidin.
Phytochemical characteristics and the study of acute toxicity of extracts from fruit Рrunus domestica
Authors: Сенюк І. В. , Кравченко В. М. , Амін Бенарафа Ібрахім 
Published: March 2022

The increased demand for modern phytopreparations is dictated by their wide application in the complex treatment of various diseases, the presence of low toxicity and the pharmacoeconomic component. Phytochemical analysis of medicinal plants reveals not only potential therapeutic effects, but also assumes their toxicological properties. In this context, the Prunus domestica, widely spread on the territory of our country and well known for its medicinal properties and applications in folk medicine, has attracted our attention.
The aim of the work was to investigate the phytochemical composition of extracts obtained from fruit Prunus domestica and to study their toxic properties.
Phytochemical analysis of the extracts obtained from fruits Prunus domestica was carried out according to the original method of extracting biologically active compounds, using instrumental research methods using modern laboratory analytical equipment.
Studies of the safety of four extracts from Prunus domestica (liquid EC-1, EC-2 and dry CEPC, CEV) with the calculation of median lethal doses were carried out on mice and rats with the single intragastric and intraperitoneal routes of administration according to the method of T. V. Pastushenko. The degree of toxicity was determined according to the classification of K. K. Sidorov.
Phytochemical study of extracts from fruit Prunus domestica provided information on the presence in their chemical composition of flavonoids, the sum of phenolic compounds, anthocyanins, neutral sugars, amino acids, organic and hydroxycinnamic acids. A higher content of the sum of phenolic compounds in the aqueous (ЕС-1) and alcoholic extracts (ЕС-2) as well as the presence of neutral sugars as products of hydrolysis of homopolysaccharides (СEV extract) and heteropolysaccharides (CEPC extract).
Experimental studies proved that EC-1, EC-2, CEPC and SEV extracts had low toxicity beyond 15 000 mg/kg when administered orally and 3 000 mg/kg when administered intraperitoneally. The LD50 of the studied extracts of mice and rats after intraperitoneal injection was determined, which was more than 3 000 mg/kg.
The chemical composition of biologically active compounds of extracts from the fruit Prunus domestica, which provides promising directions for further study of their pharmacological properties, has been investigated.
Analysis of experimental data on acute toxicity of the studied extracts showed that they belong to the IV class of toxicity “relatively harmless substances", according to K. K. Sidorov classification. The LD50 of extracts from the fruit Prunus domestica for oral administration could not be determined, and the LD50 of the studied extracts for mice and rats after intraperitoneal administration was more than 3 000 mg/kg.