bluuebunny/crossref_metadata_2025_split huggingface dataset:
Portal Hypertension: Current Surgical Management
Authors: Wancata Lauren M. , Connelly Christopher R. , Orloff Susan L. 
Published: June 2022

AbstractPortal hypertension occurs due to multiple disorders of the liver and its circulation. It is defined as an elevated pressure gradient between the portal circulation and the systemic circulation. The primary clinical consequences of portal hypertension are ascites and the development of portosystemic varices, which may cause life threatening hemorrhage. Modern management of portal hypertension includes medical, endoscopic therapy and transjugular intrahepatic portosystemic shunt placement by interventional radiology. Historically, portal hypertension was treated through the creation of surgical portosystemic shunts. In this chapter, the physiology of portal hypertension and the approaches to its management will be discussed. Specifically, the chapter will focus on indications, technical considerations, and types of surgical shunts used to treat portal hypertension, as well as literature supporting these procedures. Three case reports describing recent successful surgical shunt creation will be presented. Although portosystemic surgical shunt creation is performed far less frequently as medical, endoscopic and radiologic interventions have improved, this chapter illustrates that this procedure is a vital tool to be used in the treatment of portal hypertension.
Quantitative analysis of trace N2, Ar in O2 using glow discharge optical emission spectroscopy
Authors: Oh Myoung-Kyu , Kim Hyeonju , Kim Jung-uk , Kwak Gye-Hoon 
Published: June 2022

A trace level of N2 and Ar gases in O2 ambience were quantitatively analyzed for the first time by glow discharge optical emission spectroscopy. Microplasma was generated in a compact gas cell by a metal (Au) electrode pair of 1 mm diameter and ∼1 mm separation with the driving voltage of ∼0.9 kV and the current of ∼5 mA in ∼60 Torr. 358 and 813 nm optical emission bands were used for N2 and Ar detection, respectively. A spectroscopy fiber bundle having a circular input cross section of ∼700 µm in diameter and an output of 100 µm in width and 3 mm in height was employed to promote the signal collection efficiency while preserving high spectral resolution. As a result, the detection sensitivities &lt;1 ppm (3 − σ) were attained for both N2 and Ar within 10 s. The detection accuracy was also promoted by correcting the N2 and Ar band signal intensities using the neighboring O emission band intensities, which led to detection errors &lt;2% (3 − σ) for both N2 and Ar.
Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia
Authors: Dong Han , Ham James Dongjoo , Hu Guangan , Xie Guozhu , Vergara Juliana , Liang Yong , Ali Alaa , Tarannum Mubin , Donner Hannah , Baginska Joanna , Abdulhamid Yasmin , Dinh Khanhlinh , Soiffer Robert J. , Ritz Jerome , Glimcher Laurie H. , Chen Jianzhu , Romee Rizwan 
Published: June 2022

Acute myeloid leukemia (AML) remains a therapeutic challenge, and a paucity of tumor-specific targets has significantly hampered the development of effective immune-based therapies. Recent paradigm-changing studies have shown that natural killer (NK) cells exhibit innate memory upon brief activation with IL-12 and IL-18, leading to cytokine-induced memory-like (CIML) NK cell differentiation. CIML NK cells have enhanced antitumor activity and have shown promising results in early phase clinical trials in patients with relapsed/refractory AML. Here, we show that arming CIML NK cells with a neoepitope-specific chimeric antigen receptor (CAR) significantly enhances their antitumor responses to nucleophosphmin-1 (NPM1)-mutated AML while avoiding off-target toxicity. CIML NK cells differentiated from peripheral blood NK cells were efficiently transduced to express a TCR-like CAR that specifically recognizes a neoepitope derived from the cytosolic oncogenic NPM1-mutated protein presented by HLA-A2. These CAR CIML NK cells displayed enhanced activity against NPM1-mutated AML cell lines and patient-derived leukemic blast cells. CAR CIML NK cells persisted in vivo and significantly improved AML outcomes in xenograft models. Single-cell RNA sequencing and mass cytometry analyses identified up-regulation of cell proliferation, protein folding, immune responses, and major metabolic pathways in CAR-transduced CIML NK cells, resulting in tumor-specific, CAR-dependent activation and function in response to AML target cells. Thus, efficient arming of CIML NK cells with an NPM1-mutation-specific TCR-like CAR substantially improves their innate antitumor responses against an otherwise intracellular mutant protein. These preclinical findings justify evaluating this approach in clinical trials in HLA-A2
+
AML patients with NPM1c mutations.
Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing
Authors: Xu Jun , Liu Yifang , Li Hongjie , Tarashansky Alexander J. , Kalicki Colin H. , Hung Ruei-Jiun , Hu Yanhui , Comjean Aram , Kolluru Sai Saroja , Wang Bo , Quake Stephen R. , Luo Liqun , McMahon Andrew P. , Dow Julian A. T. , Perrimon Norbert 
Published: June 2022

Recent advances in single-cell sequencing provide a unique opportunity to gain novel insights into the diversity, lineage, and functions of cell types constituting a tissue/organ. Here, we performed a single-nucleus study of the adult
Drosophila
renal system, consisting of Malpighian tubules and nephrocytes, which shares similarities with the mammalian kidney. We identified 11 distinct clusters representing renal stem cells, stellate cells, regionally specific principal cells, garland nephrocyte cells, and pericardial nephrocytes. Characterization of the transcription factors specific to each cluster identified
fruitless
(
fru
) as playing a role in stem cell regeneration and
Hepatocyte nuclear factor 4
(
Hnf4
) in regulating glycogen and triglyceride metabolism. In addition, we identified a number of genes, including
Rho guanine nucleotide exchange factor at 64C
(
RhoGEF64c
),
Frequenin 2
(
Frq2
),
Prip
, and
CG1093
that are involved in regulating the unusual star shape of stellate cells. Importantly, the single-nucleus dataset allows visualization of the expression at the organ level of genes involved in ion transport and junctional permeability, providing a systems-level view of the organization and physiological roles of the tubules. Finally, a cross-species analysis allowed us to match the fly kidney cell types to mouse kidney cell types and planarian protonephridia, knowledge that will help the generation of kidney disease models. Altogether, our study provides a comprehensive resource for studying the fly kidney.
“This side is the real world and the other one is like Minecraft”
Authors: Burri Michael , Mantei Jessica , Kervin Lisa 
Published: June 2022

Abstract
English has been introduced as a core subject in primary schools across Asia over the past decade. Besides aiming to improve the English proficiency of Japanese primary school students, Japan’s recent reforms also mandate the development of children’s awareness of cultures other than their own. However, relatively little is known about pedagogical strategies to achieve cultural awareness in the Japanese primary school classroom. The objective of this study was, therefore, to utilize an almost wordless picture book and examine the ways children interpret stories about people from cultures other than their own. This study explored the independent meaning-making practices and processes of six Japanese primary school students as they viewed, without teacher intervention, Mirror, an Australian almost wordless picture book about the daily lives of an Australian and a Moroccan family. Interview and observation data provided insights into the children’s meaning-making processes and the ways they interpreted the messages within the stories that led to a range of understandings and misunderstandings across the cultures. The paper concludes with a discussion about pedagogical implications for supporting the development of cultural awareness, for challenging cultural stereotypes, and for facilitating English language learning processes.
Research on acoustic sensing device based on microfiber knot resonator
Authors: Zhao Rongyu , Cui Jiangong , Yu Yaxin , Zhai Xiaoping , Chu Xiaoxia , Zhu Min , Wu Bofeng , Yang Yuhua , Wang Renxin , He Changde , Zhang Guojun , Zhang Wendong 
Published: June 2022

Abstract
An acoustic sensor packaged with polydimethylsiloxane film sandwich structure is proposed in this paper. The sensor uses a flat glass with a square hole in the middle as the substrate structure. The cavity length of the microfiber knot resonator is significantly changed by the applied acoustic pressure, which is ultimately manifested as a change in the strength of the sensor signal. The sensor has a good response at frequencies from 0.1 to 10 kHz, and has a sensitivity of 0.92 mV Pa−1 at 1 kHz acoustic frequency. The sensor studied in this paper has the advantages of wide frequency band, small size and low cost, and has a good application prospect in the field of acoustic signal detection.
Telescopic ball bar with an indexing joint for measuring machine tool error
Authors: Wang Wen , Sun Tao , Chen Zhanfeng , Wu Haimei , Lu Keqing , Wang Chuanyong , Xu Kaifei , Sang Zhiqian , Yang He , Shi Guang 
Published: June 2022

Abstract
Measurement and compensation of these errors can improve the machining accuracy of a machine tool. Double ball bar is one of the traditional instruments for measuring machine tool errors, whose measurement range depends on the length of the bar since the sensor has a stretching range of only 2 mm. Some extension bars are usually used to extend the measuring range, but each replacement of an extension bar requires recalibration and installation. In this paper, a novel measuring equipment based on telescopic ball bar with an indexing joint (IJ-TBB) is proposed, which has six measuring ranges after a single installation. First, the basic structure and measuring principle of the IJ-TBB are introduced. Then, the effect of structural errors of IJ-TBB on the measurement accuracy is studied. Next, the error amplification characteristic and measurement resolution of the IJ-TBB are analyzed. Finally, an experiment was carried out to validate the accuracy of the IJ-TBB. The results reveal that the IJ-TBB has high precision and high efficiency. It is valuable to extend the measurement range and improve the measurement efficiency of machine tools.
An EMAT for improving the purity and amplitude of S0 Lamb waves
Authors: Yang Xufei , Zhang Wenlong , Wu Yutang , Wu Yunxin , Zhang Tao 
Published: June 2022

Abstract
Different waves of the Lamb waves may be superimposed in practical tests due to their multimodal characteristics and dispersion characteristics, thus significantly increasing the difficulty of later signal analysis and creating a massive limitation to their application in non-destructive testing. Only a single magnet was used to generate a static magnetic field in the traditional S0 mode Lamb wave (S0 wave) electromagnetic acoustic transducer (EMAT), which resulted in a less pure S0 wave. Additionally, the accompanying A0 mode Lamb wave (A0 wave) will decrease the accuracy of the results in defect detection and increase the difficulty of the signal processing. To obtain a single-mode S0 wave, a periodic magnet structure EMAT structure was proposed in this study. Finite element models were established, and the effect of single and periodic magnet structure on the static magnetic field was analyzed. The periodic magnet structure EMAT can substantially enhance the S0 mode Lamb wave amplitude by increasing the flux density of the local magnetic field using periodically arranged magnets. However, it also causes enhancement to the A0 wave and decreases the detection accuracy. An improved EMAT was further proposed to increase the S0 wave amplitude with no enhancement to the A0 wave amplitude. Experiments were conducted, and two types of EMAT were comparatively investigated, which agreed with the simulated results. The S0 wave amplitude can be increased by seven times with the improved EMAT compared to traditional EMAT, and the A0 wave is completely submerged in the noise. The improved EMAT proposed in this study can provide guidance for single-mode S0 wave defect detection.
A hybrid method for lattice image reconstruction and deformation analysis
Authors: Zhang Hongye , Peng Runlai , Wen Huihui , Xie Huimin , Liu Zhanwei 
Published: June 2022

Abstract
Geometric phase analysis (GPA) is a powerful tool to investigate the deformation in nanoscale measurement, especially in dealing with high-resolution transmission electron microscopy images. The traditional GPA method using the fast Fourier transform is built on the relationship between the displacement and the phase difference. In this paper, a nano-grid method based on real-space lattice image processing was firstly proposed to enable the measurement of nanoscale interface flatness, and the thickness of different components. Then, a hybrid method for lattice image reconstruction and deformation analysis was developed. The hybrid method enables simultaneous real-space and frequency-domain processing, thus, compensating for the shortcomings of the GPA method when measuring samples with large deformations or containing cracks while retaining its measurement accuracy.
Single projection driven real-time multi-contrast (SPIDERM) MR imaging using pre-learned spatial subspace and linear transformation
Authors: Han Pei , Chen Junzhou , Xiao Jiayu , Han Fei , Hu Zhehao , Yang Wensha , Cao Minsong , Ling Diane C , Li Debiao , Christodoulou Anthony G , Fan Zhaoyang 
Published: June 2022

Abstract

Objective. To develop and test the feasibility of a novel Single ProjectIon DrivEn Real-time Multi-contrast (SPIDERM) MR imaging technique that can generate real-time 3D images on-the-fly with flexible contrast weightings and a low latency. Approach. In SPIDERM, a ‘prep’ scan is first performed, with sparse k-space sampling periodically interleaved with the central k-space line (navigator data), to learn a subject-specific model, incorporating a spatial subspace and a linear transformation between navigator data and subspace coordinates. A ‘live’ scan is then performed by repeatedly acquiring the central k-space line only to dynamically determine subspace coordinates. With the ‘prep’-learned subspace and ‘live’ coordinates, real-time 3D images are generated on-the-fly with computationally efficient matrix multiplication. When implemented based on a multi-contrast pulse sequence, SPIDERM further allows for data-driven image contrast regeneration to convert real-time contrast-varying images into contrast-frozen images at user’s discretion while maintaining motion states. Both digital phantom and in-vivo experiments were performed to evaluate the technical feasibility of SPIDERM. Main results. The elapsed time from the input of the central k-space line to the generation of real-time contrast-frozen 3D images was approximately 45 ms, permitting a latency of 55 ms or less. Motion displacement measured from SPIDERM and reference images showed excellent correlation (

R

2

≥
0.983

). Geometric variation from the ground truth in the digital phantom was acceptable as demonstrated by pancreas contour analysis (Dice ≥ 0.84, mean surface distance ≤ 0.95 mm). Quantitative image quality metrics showed good consistency between reference images and contrast-varying SPIDREM images in in-vivo studies (mean

NMRSE
=
0.141
,
PSNR
=
3
0.12
,
SSIM
=
0.88

). Significance. SPIDERM is capable of generating real-time multi-contrast 3D images with a low latency. An imaging framework based on SPIDERM has the potential to serve as a standalone package for MR-guided radiation therapy by offering adaptive simulation through a ‘prep’ scan and real-time image guidance through a ‘live’ scan.
Passively Q-switched Pr:YLF laser with a Co,Fe:ZnSe saturable absorber
Authors: Ud Din Syed Zaheer , Yang Zixin , Li Shanming , Hang Yin , Yang Qi , Li Chun , Ren Xianghe , Zu Yuqian 
Published: June 2022

Abstract
An iron-cobalt co-doped ZnSe polycrystalline (Co,Fe:ZnSe) was prepared by the thermal diffusion method, and its nonlinear optical response was characterized for the first time. Using the as-prepared Co,Fe:ZnSe as a saturable absorber (SA), the blue laser diode pumped Q-switched Pr:YLF laser at 607 nm (orange), and 639 nm (red) was successfully realized. For 607 nm, the Q-switched laser delivered the shortest pulse width of 59 ns with a repetition rate of 15 kHz. For 639 nm, the shortest pulse width and maximum repetition rate were 119 ns and 32 kHz, respectively. The experimental results indicate that the Co,Fe:ZnSe SA has a great potential for optical pulse generation in the visible region.
Reduction in RF sheath rectification with insulating antenna enclosure walls
Authors: Bal G. , Compernolle B.V. , Pribyl P. , Martin M.J. , Larson J. , Carter T.A. 
Published: June 2022

Abstract
Radiofrequency (RF) sheath rectification is one of the most prominent deleterious effects associated with ion cyclotron range of frequencies (ICRF) heating in fusion plasmas. RF sheaths and associated effects, such as impurity generation and convective cell generation, need to be mitigated to ensure that ICRF is a viable option for heating in future fusion devices. Experiments were performed on the Large Plasma Device (LAPD) at UCLA to explore the effects of using electrically-insulating antenna enclosures on RF rectified sheaths. Three different enclosure side-wall materials were used, including copper, MACOR (electrically insulating), and MACOR over copper. In the case of the MACOR–copper side walls, the non-conductive MACOR material was exposed to the bulk plasma but a layer of copper was added below to allow for image currents to flow. All three of the experiments had similar plasma density, temperature, and background magnetic field. In the case of the copper enclosure, RF rectified potentials, many times the local electron temperature, and associated formation of convective cells were observed and reported Martin M. et al (2017 Phys. Rev. Lett.
119 205002). In the experiments with MACOR and MACOR–copper enclosures, RF rectification was significantly reduced. Additionally, these latter two experiments showed no evidence of convective cell formation. Although the results from the MACOR experiment are reminiscent of the results obtained in ASDEX-U with a three-strap antenna optimized to reduce image currents on the antenna limiters Bobkov V. et al (2016 Nucl. Fusion
56 084001), the MACOR–copper experiment seems to suggest that insulating plasma facing materials have at least an equally strong impact on reducing potential rectification.
Design and performance of a terahertz Fourier transform spectrometer
for axion dark matter experiments
Authors: Dona K. , Liu J. , Kurinsky N. , Miller D. , Barry P. , Chang C. , Sonnenschein A. 
Published: June 2022

Abstract
Dedicated spectrometers for terahertz radiation with [0.3,
30] THz frequencies using traditional optomechanical interferometry
are substantially less common than their infrared and microwave
counterparts. This paper presents public documentation for the
design and initial performance measurements of a tabletop Fourier
transform spectrometer (FTS) for terahertz spectral analysis using
infrared optics in a Michelson arrangement. This is coupled to a
broadband pyroelectric photodetector designed for [0.1, 30] THz
frequencies. We measure spectra of narrowband and broadband input
radiation to characterize the performance of this instrument above
10 THz, where signal-to-noise is high. This device is constructed
in the context of research-and-development for the recently-proposed
Broadband Reflector Experiment for Axion Detection (BREAD), where
the optical components can be applied to ongoing efforts for testing
the pilot experiment.
Determination of Oxidation Stability of Palm-Oil Biodiesel and Biodiesel-Diesel Blends by Rancimat and RSSOT Methods
Authors: Devitasari Rossy Dwi , Fathurrahman Nur Allif , Katili Marsha , Wibowo Cahyo Setyo , Bethari Sylvia Ayu , Anggarani Riesta , Aisyah Lies , Maymuchar  
Published: June 2022

Abstract
Determination of oxidation stability becomes a critical fundamental analysis to ensure biodiesel quality. The biodiesel’s degradation by oxidation may compromise fuel properties and engine durability due to forming products of fatty acid decomposition. In this present study, the oxidation stability of palm-oil biodiesel and its blends with diesel fuel (cetane number 48) was determined using EN 15751 (Rancimat Method) and ASTM D 7545 (Rapid Small Scale Oxidation Test, RSSOT Method). Here, the determination from either test was compared and analyzed using ANOVA and the mathematical function. Based on the result, diesel fuel has oxidation stability 11 times higher than palm-oil biodiesel, analyzed by the RSSOT method. Additionally, the correlation factor of oxidation stability of biodiesel samples in this work was 21.52 and for biodiesel blend (B20 to B90) it was 23.66 that was used as a conversion oxidation value between RSSOT and Rancimat method. The models presented a high correlation with the R2
values of 0.9535 for biodiesel samples and 0.9823 for biodiesel blend (B20-B90) indicated the accuracy of the models to predict the value of oxidation stability of both the Rancimat and the RSSOT accelerated oxidation methods.
In vitro long term differentiation and functionality of three-dimensional bioprinted primary human hepatocytes: application for in vivo engraftment
Authors: Cuvellier Marie , Rose Sophie , Ezan Frédéric , Jarry Ulrich , de Oliveira Hugo , Bruyère Arnaud , Drieu La Rochelle Christophe , Legagneux Vincent , Langouët Sophie , Baffet Georges 
Published: June 2022

Abstract
In recent decades, 3D in vitro cultures of primary human hepatocytes (PHHs) have been increasingly developed to establish models capable of faithfully mimicking main liver functions. The use of 3D bioprinting, capable of recreating structures composed of cells embedded in matrix with controlled microarchitectures, is an emergent key feature for tissue engineering. In this work, we used an extrusion-based system to print PHH in a methacrylated gelatin (GelMa) matrix. PHH bioprinted in GelMa rapidly organized into polarized hollow spheroids and were viable for at least 28 d of culture. These PHH were highly differentiated with maintenance of liver differentiation genes over time, as demonstrated by transcriptomic analysis and functional approaches. The cells were polarized with localization of apico/canalicular regions, and displayed activities of phase I and II biotransformation enzymes that could be regulated by inducers. Furthermore, the implantation of the bioprinted structures in mice demonstrated their capability to vascularize, and their ability to maintain human hepatic specific functions for at least 28 d was illustrated by albumin secretion and debrisoquine metabolism. This model could hold great promise for human liver tissue generation and its use in future biotechnological developments.