bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining the relationship between preoperative mental health scores and postoperative outcomes in adult spinal deformity surgeries
Authors: Morrissette Cole , Park Paul J. , Cerpa Meghan , Lenke Lawrence G. 
Published: April 2022

OBJECTIVE
The objective of this study was to examine the relationship between the mental health domain of the refined 22-item Scoliosis Research Society Outcome Questionnaire (SRS) and various postoperative outcome measures in the adult spinal deformity (ASD) population. Given the scale and involved nature of deformity surgery, some surgeons have proposed that preoperative mental health scores (MHSs) may assist in screening out poor surgical candidates. In this study, the authors aimed to further assess the SRS MHS as a preoperative metric and its association with postoperative outcomes and to comment on its potential use in patient selection and optimization for ASD surgery.

METHODS
The authors conducted a retrospective study of 100 consecutive patients who had undergone primary or revision ASD surgery at a single academic institution between 2015 and 2019. Each patient had a minimum 2-year follow-up. Patients were categorized on the basis of their baseline mental health per the SRS mental health domain, with a score < 4 indicating low baseline mental health (LMH) and a score ≥ 4 indicating high baseline mental health (HMH). Baseline and follow-up SRS and Oswestry Disability Index scores, surgical procedures, lengths of stay, discharge locations, intraoperative or postoperative complications, and other outcome metrics were then compared between the HMH and LMH groups, as well as these groups stratified by an age ≤ 45 and > 45 years.

RESULTS
Among patients aged ≤ 45 and those aged > 45, the LMH group had significantly worse baseline health-related quality-of-life (HRQOL) metrics in nearly all domains. The LMH group also had an increased median estimated blood loss (EBL; 1200 vs 800 ml, p = 0.0026) and longer average surgical duration (8.3 ± 2.8 vs 6.9 ± 2.6 hours, p = 0.014). Both LMH and HMH groups had significant improvements in nearly all HRQOL measures postoperatively. Despite their worse preoperative HRQOL baseline, patients in the LMH group actually improved the most and reached the same HRQOL endpoints as those in the HMH group.

CONCLUSIONS
While patients with lower baseline MHSs may require slightly longer hospital courses or more frequent discharges to rehabilitation facilities, these patients actually attain greater absolute improvements from their preoperative baseline and surprisingly have the same postoperative HRQOL metrics as the patients with high MHSs, despite their poorer starting point. This finding suggests that patients with LMH may be uniquely positioned to substantially benefit from surgical intervention and improve their HRQOL scores and thus should be considered for ASD surgery to an extent similar to patients with HMH.
Characteristics of patients undergoing revision surgery for proximal junctional failure after adult spinal deformity surgery: revalidation of the Hart–International Spine Study Group proximal junctional kyphosis severity scale
Authors: Raj Aditya , Lee Chong-Suh , Park Jin-Sung , Kang Byeong-Jik , Shin Tae Soo , Park Se-Jun 
Published: April 2022

OBJECTIVE
Score on the proximal junctional kyphosis severity scale (PJKSS) has been validated to show good correlations with likelihood of revision surgery for proximal junctional failure (PJF) after surgical treatment of adult spinal deformity (ASD). However, if the patient has progressive neurological deterioration, revision surgery should be considered regardless of severity based on PJKSS score. This study aimed to revalidate the correlation of PJKSS score with likelihood of revision surgery in patients with PJF but without neurological deficit. In addition, the authors provide the cutoff score on PJKSS that indicates need for revision surgery.

METHODS
A retrospective study was performed. Among 360 patients who underwent fusion of more than 4 segments including the sacrum, 83 patients who developed PJF without acute neurological deficit were included. Thirty patients underwent revision surgery (R group) and 53 patients did not undergo revision surgery (NR group). All components of PJKSS and variables other than those included in PJKSS were compared between groups. The cutoff score on PJKSS that indicated need for revision surgery was calculated with receiver operating characteristic curve analysis. Multivariate analysis with logistic regression was performed to identify which variables were most predictive of revision surgery.

RESULTS
The mean patient age at the time of index surgery was 69.4 years, and the mean fusion length was 6.1 segments. All components of PJKSS, such as focal pain, instrumentation problem, change in kyphosis, fracture at the uppermost instrumented vertebra (UIV)/UIV+1, and level of UIV, were significantly different between groups. The average total PJKSS score was significantly greater in the R group than in the NR group (6.0 vs 3.9, p < 0.001). The calculated cutoff score was 4.5, with 70% sensitivity and specificity. There were no significant between-group differences in patient, surgical, and radiographic factors (other than the PJKSS components). Three factors were significantly associated with revision surgery on multivariate analysis: instrumentation problem (OR 8.160, p = 0.004), change in kyphosis (OR 4.809, p = 0.026), and UIV/UIV+1 fracture (OR 6.462, p = 0.002).

CONCLUSIONS
PJKSS score positively predicted need for revision surgery in patients with PJF who were neurologically intact. The calculated cutoff score on PJKSS that indicated need for revision surgery was 4.5, with 70% sensitivity and specificity. The factor most responsible for revision surgery was bony failure with > 20° focal kyphotic deformity. Therefore, early revision surgery should be considered for these patients even in the absence of neurological deficit.
The two-scale-transformation method
Authors: Wiedemann David 
Published: April 2022

We present the two-scale-transformation method which allows rigorous homogenisation of problems defined in locally periodic domains. This method transforms such problems into periodic domains in order to facilitate the passage to the limit. The idea of transforming problems into periodic domains originates from the homogenisation of problems defined in evolving microstructure and has been applied in several works. However, only the homogenisation of the periodic substitute problems was proven, whereas the method itself was just postulated (i.e. the equivalence to the homogenisation of the actual problem had to be assumed). In this work, we develop this idea further and formulate a rigorous two-scale convergence concept for microscopic transformation. Thus, we can prove that the homogenisation of the periodic substitute problem is equivalent to the homogenisation of the actual problem. Moreover, we show a new two-scale transformation rule for gradients which enables the derivation of new limit problems that are now transformationally independent.
The evaluation of glutamine supplementation into the diet on the growth performance, intestinal structure and function of striped catfish Pangasius hypophthalmus (Sauvage, 1878) fry
Authors: Dewi Uttari , Jusadi Dedi , Setiawati Mia , Nuryati Sri 
Published: April 2022

A triplicate experiment was conducted to evaluate the effect of glutamine supplementation in the diet on the structure and function of intestine and the growth performance of striped catfish Pangasius hypopthalmus. Forty fishes with an initial body weight of 0.82 ± 0.01 g were distributed into a rectangular aquarium with a size of 60×50×40 cm and a water volume of 70 L. Fish were fed on the diet supplemented with glutamine of either 0, 1, 2, or 3%, respectively. Fish were fed on the diet at satiation for 60 days. Results showed that fish fed on the diet supplemented with 1, and 2% of glutamine significantly had the highest growth performance, including specific growth rate, protein retention, and feed efficiency. On the other hand, feeding on a diet supplemented with 3% of glutamine did not significantly affect the growth performance of fish. Fish in 1% and 2% glutamine treatments had better structure and function of intestine than two other groups of fish, namely the ratio of intestine length with body length, villus surface area, and protease enzyme activity. Thus, supplementation of 1% and 2% glutamine in the diet improves the structure and function of intestine and the growth performance of striped catfish.
Abstrak
Percobaan dilakukan untuk mengevaluasi pengaruh penambahan glutamin pada pakan terhadap struktur dan fungsi usus, serta kinerja pertumbuhan ikan patin Pangasius hypopthalmus. Ikan uji yang digunakan sebanyak 40 ekor dengan bobot awal 0,82 ± 0,01 g dipelihara dalam akuarium berukuran 60 × 50 × 40 cm dan volume air 70 L. Ikan diberi pakan uji dengan penambahan glutamin 0, 1, 2, dan 3%. Ikan diberi pakan uji secara at satiation selama 60 hari. Hasil penelitian menunjukkan bahwa ikan yang diberi pakan dengan penambahan glutamin 1% dan 2% secara signifikan menghasilkan kinerja pertumbuhan tertinggi, termasuk laju pertumbuhan spesifik, retensi protein, dan efisiensi pakan. Di sisi lain, pakan yang ditambah dengan glutamin 3% tidak signifikan memengaruhi kinerja pertumbuhan ikan. Ikan uji pada perlakuan glutamin 1% dan 2% menghasilkan struktur dan fungsi usus yang lebih baik dibanding perlakuan lainnya, yakni rasio panjang usus dengan panjang tubuh, luas permukaan vili dan aktivitas enzim protease. Disimpulkan bahwa penambahan glutamin 1% dan 2% pada pakan meningkatkan struktur dan fungsi usus serta kinerja pertumbuhan benih ikan patin.
Determination of bacteria morphotypes associated with the rhizosphere of organic coffee plantations
Authors: AGUILAR-MENDEZ ROCIO , Nicólas-Salazar Cynthia Lizbeth , Martínez-Bolaños Misael , Avendaño-Arrazate Carlos Hugo , Lozano-Trejo Salvador , Castañeda-Hidalgo Ernesto , Santiago-Martínez Gisela Margarita , Diaz-Zorrilla Gustavo Omar 
Published: April 2022

Objective: To determine the bacterial diversity in the rhizosphere of coffee (Coffea arabica L.) in coffee plantations in Oaxaca, Mexico.
Design/methodology/approach: Soil samples collected from organic arabian coffee plantations in the Loxicha region of Oaxaca were analyzed to isolate and characterize bacterial populations associated with the rhizosphere of those plantations. Samples were collected from six sites in three altitude ranges (two sampling sites per each range): low (≥1,200, ≤1,400 masl), medium (≥1,700, ≤1,800 masl), and high (≥1,900 masl). Tukey’s test was used to compare the bacteria population distribution per altitude range.
A multivariate analysis (Principal Component Analysis and Hierarchical Cluster Analysis) was performed considering four morphological —shape, surface, border, and color— and two microscopic —type and Gram— characteristics of the colonies.

Results: Forty-three bacterial colonies were isolated and purified; their population distribution showed a significant difference (Tukey α = 0.5) with respect to the altitude range in which they were collected. The Principal Components Analysis showed that the first three principal components accounted for 74.19% of the total variation of the 43 bacterial colonies, indicating that the evaluated characteristics were widely distributed. The Hierarchical Cluster Analysis determined eight groups and divided them into subgroups, based on the semi partial correlation coefficient (0.05).
Study limitations/implications: The environmental conditions where bacteria grow allow changes in the interspecific variation of each species.
Findings/conclusions: The morphological and microscopic characterization of the bacterial colonies shows a high variability that is expressed in characteristics, indicating a high diversity of bacterial species in organically-managed coffee soils in Oaxaca
Spiritual Well-Being and Optimism as Contributing Factors that Influence the Subjective Well-Being of Cancer Patients
Authors: Werdani Yesiana Dwi Wahyu 
Published: April 2022

Background: Cancer is a serious stressor that induces spiritual distress, loss of optimism, and dissatisfaction with subjective well-being. This study aims to determine that spiritual well-being (SWB) and optimism as factors that contribute to influencing the subjective well-being of cancer patients. Methods: This study had a cross-sectional design. A total of 88 cancer patients from public health centers in Surabaya and the Indonesian Cancer Foundation of East Java were selected to be sampled by consecutive sampling in 4 months. The Instruments used were valid and reliable throughout the test, comprising of the spiritual well-being scale, the 9-item version of the personal optimism scale, self-efficacy optimism scale, and satisfaction with life scale. The ethical feasibility was declared ethical. Data were analyzed using Pearson Product Moment Correlation Test and Linear Regression Test with p < 0.05. Results: The demographic data show that the mean age of 52.5 years, female gender (84%), being married (78.4%), having cervical cancer (52.3%), having stage-III cancer (55.7%), having cancer therapy (surgery, chemotherapy, and radiotherapy) (37.5%), and patients newly diagnosed from 6 months to 1 year (33%). The mean score of SWB was 99.67 (high SWB), optimism 20.03 (high optimism), and subjective well-being 24.18 (good subjective well-being). Pearson Product Moment Correlation Test between SWB and optimism showed p < 0.001, indicating that SWB had a significant relationship with optimism; patients with high SWB will have high optimism. From the Linear Regression Test, there was a significant effect of SWB on subjective well-being (r2 = 0.982 and p < 0.001) and optimism on subjective well-being as well (r2 = 0.988 and p < 0.001), meaning that patients with high SWB and high optimism tended to have good subjective well-being. Conclusions: Cancer patients who have high scores of SWB become more optimistic, which has a positive effect on the high score of subjective well-being as well.
Magnetic Resonance Findings in Adolescent Vaginal Rhabdomyosarcoma: A Rare Case Report
Authors: Pingkan Trifonia , Juniarta Fitri , Tjahjadi Hartono , Lai Meliyana 
Published: April 2022

Introduction: Rhabdomyosarcoma (RMS) is a rare soft tissue tumor, mainly affecting children, adolescents, and adults younger than 15 years, representing 3% to 4% of all childhood malignancies. Genitourinary is the second-most-common location of RMS with around 25% of cases. We describe a rare case of vaginal rhabdomyosarcoma in adolescents with huge polypoid tumors. Case Presentation: A 15-year-old female presented with vaginal bleeding for seven months. Her medical story was unremarkable. The clinical examination showed a polypoid mass prolapsed from the vagina, and the laboratory result was anemia. The pelvic magnetic resonance imaging (MRI) showed a heterogenous bulky solid tumor in the vagina. The histopathological finding revealed a sarcoma, and the immunohistochemical staining result was rhabdomyosarcoma not otherwise specified (NOS). Conclusions: Vaginal RMS is a rare malignant tumor of mesenchymal origin with skeletal muscle differentiation. Vaginal RMS is the most common site of genitourinary RMS and presents as a rapidly growing and aggressive local mass. Imaging plays an important role in the initial diagnosis of vaginal RMS, regarding the presentation of the bulky protruding tumor on the vaginal region
Uso dos serious games no Ensino Superior: Kahoot! em Odontologia Legal
Authors: Melo Cibele Virgínia Morais de , Silva Adriana Paula de Andrade da Costa e , Alencar Catarina Leite Falcão de , Lima Juvino Janmeson Batista de , Moreira Maria Helena Batista de Andrade , Ribeiro Thaíse Barros , Sousa Virgínia Lúcia Vidal Rodrigues , Bione Elys Cadete , Ximenes William dos Santos , Silva José André Carneiro da , Damacena Williany Soares , Pereira Maria Ellen Karla Cavalcante 
Published: April 2022

O auxílio das metodologias ativas promove a motivação e facilita a compreensão dos assuntos ministrados em sala. O uso de jogos – gamificação e serious games – têm sido bastante utilizados, principalmente com o acréscimo das atividades remotas por causa da pandemia da Covid-19. O Kahoot! é uma plataforma gratuita de perguntas e respostas que tem ganho muita popularidade entre os professores e deste modo, esta pesquisa objetivou contribuir para ampliar os conhecimentos acerca dos conteúdos relacionados à Odontologia Legal desenvolvidos na plataforma Kahoot!, bem como quantificar os jogos e analisar a qualidade, de acordo com o que se propõem. Foi realizado estudo de natureza descritiva e abordagem quantitativa, do tipo pesquisa laboratorial usando dados públicos do Kahoot! realizando a busca dos termos “Odontologia Legal”, “Odonto Legal” e “Odontologia Forense”, com aplicação de filtro de idiomas e análise individual de cada quiz verificando pertinência do conteúdo abordado com o tema proposto. Os resultados demonstraram inicialmente 159 quizzes, os quais após análise individual resultaram em 82 (48,4%) com conteúdo pertinente ao tema proposto, representando 51,6% de questionários com discordância. O termo com maior número de jogos associados foi “Odontologia Legal”, com 48 games. Do total de quizzes avaliados, 64,7% tratavam sobre Identificação Humana. Concluiu-se haver um grande número de jogos no Kahoot! que utilizam os termos relacionados à Odontologia Legal pesquisados, representados por 159 quizzes. No entanto, um pouco mais da metade deles, 51,6%, não apresentavam conteúdos pertinentes ao título do quiz desenvolvido, representando um limitador do uso adequado da plataforma.
Comprehensive Analysis of the Prognostic Signature of Mutation-Derived Genome Instability-Related lncRNAs for Patients With Endometrial Cancer
Authors: Liu Jinhui , Cui Guoliang , Ye Jun , Wang Yutong , Wang Can , Bai Jianling 
Published: April 2022

Background: Emerging evidence shows that genome instability-related long non-coding RNAs (lncRNAs) contribute to tumor–cell proliferation, differentiation, and metastasis. However, the biological functions and molecular mechanisms of genome instability-related lncRNAs in endometrial cancer (EC) are underexplored.Methods: EC RNA sequencing and corresponding clinical data obtained from The Cancer Genome Atlas (TCGA) database were used to screen prognostic lncRNAs associated with genomic instability via univariate and multivariate Cox regression analysis. The genomic instability-related lncRNA signature (GILncSig) was developed to assess the prognostic risk of high- and low-risk groups. The prediction performance was analyzed using receiver operating characteristic (ROC) curves. The immune status and mutational loading of different risk groups were compared. The Genomics of Drug Sensitivity in Cancer (GDSC) and the CellMiner database were used to elucidate the relationship between the correlation of prognostic lncRNAs and drug sensitivity. Finally, we used quantitative real-time PCR (qRT-PCR) to detect the expression levels of genomic instability-related lncRNAs in clinical samples.Results: GILncSig was built using five lncRNAs (AC007389.3, PIK3CD-AS2, LINC01224, AC129507.4, and GLIS3-AS1) associated with genomic instability, and their expression levels were verified using qRT-PCR. Further analysis revealed that risk score was negatively correlated with prognosis, and the ROC curve demonstrated the higher accuracy of GILncSig. Patients with a lower risk score had higher immune cell infiltration, a higher immune score, lower tumor purity, higher immunophenoscores (IPSs), lower mismatch repair protein expression, higher microsatellite instability (MSI), and a higher tumor mutation burden (TMB). Furthermore, the level of expression of prognostic lncRNAs was significantly related to the sensitivity of cancer cells to anti-tumor drugs.Conclusion: A novel signature composed of five prognostic lncRNAs associated with genome instability can be used to predict prognosis, influence immune status, and chemotherapeutic drug sensitivity in EC.
Association of Sleep Patterns and Lifestyles With Incident Hypertension: Evidence From a Large Population-Based Cohort Study
Authors: Lv Yanling , Jiang Guanhua , Tan Xiao , Bao Wei , Chen Liangkai , Liu Liegang 
Published: April 2022

BackgroundAdherence to a healthy lifestyle (no smoking, consuming a healthy diet, engaging in physical activity, and maintaining a healthy weight) is recommended in current guidelines for hypertension prevention. However, evidence regarding the association between sleep behaviors, independently and jointly with traditional lifestyle factors, and the risk of hypertension is limited.MethodsThis prospective study included 165,493 participants who are free of hypertension at baseline from the UK Biobank. Sleep behaviors, including chronotype, sleep duration, insomnia, snoring, and daytime sleepiness were used to construct a healthy sleep score. We also derived a healthy lifestyle score based on smoking status, diet quality, physical activity, and body mass index (BMI). Cox proportional hazards regression models and competing risk analyses were used to estimate the associations of the healthy sleep score and healthy lifestyle score with the risk of hypertension. The population attributable risk percent (PAR%) was estimated for increased cases of hypertension due to poor adherence to a healthy sleep pattern or a healthy lifestyle.ResultsA total of 10,941 incident hypertension cases were documented during a median of 11.8 years of follow-up. The multivariable-adjusted hazard ratio (HR) for hypertension was 0.58 [95% confidence interval (CI): 0.52, 0.65] for participants with a sleep score of 5 compared with 0–1, and 0.48 (95% CI: 0.43, 0.54) for participants with a lifestyle score of 4 compared with those who scored 0. For joint association, those with a poor sleep pattern and a poor lifestyle had the highest risk of hypertension [HR: 2.41 (95% CI: 2.12, 2.74)]. PAR% was 14.7% (95% CI: 12.3%, 17.1%), 20.1% (95% CI: 17.6%, 22.6%), and 31.7% (95% CI: 27.6%, 35.6%) for poor adherence to a healthy sleep pattern, a healthy lifestyle, and the combination of a healthy sleep pattern and a healthy lifestyle.ConclusionBoth a healthy sleep pattern and a healthy lifestyle were associated with a lower risk of hypertension, and the benefits of adhering to a healthy sleep pattern complement the well-established lifestyle for the optimal primary prevention of hypertension. These findings support the current perspective that a healthy sleep pattern is an important part of a healthful and productive lifestyle for hypertension prevention.