bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repeatability and Agreement of a New Scheimpflug Device and a Hartmann-Shack Aberrometer With a Ray-Tracing Aberrometer in Normal, Keratoconus, and CXL Groups
Authors: Kundu Gairik , Shetty Rohit , Ranade Reshma , Trivedi Divya , Lalgudi Vaitheeswaran Ganesan , Nuijts Rudy M.M.A. , Annavajjhala Sriram , Khamar Pooja 
Published: March 2022

PURPOSE:
To assess repeatability and agreement of a Scheimpflug topographer and a Hartmann-Shack aberrometer with a ray-tracing aberrometer in normal, keratoconus, and corneal cross-linking (CXL) groups.

METHODS:

In this cross-sectional, observational study, normal, keratoconus, and CXL groups with 125 eyes in each of the three groups were included. All eyes underwent three sets of measurements, at a single visit, using the Pentacam AXL Wave (Oculus Optikgeräte GmbH) and iTrace (Tracey Technologies). Keratometry, pachymetry, objective refraction, and total ocular aberrations including root mean square (RMS) lower order aberrations (LOAs), RMS higher order aberrations (HOAs), RMS coma, and spherical aberrations (SA) were analyzed. Objective assessment of haze after CXL was done using the Pentacam AXL Wave. Repeatability was assessed using within-subject standard deviation (Sw), test–retest variability, within-subject coefficient of variation (COV), and intraclass correlation coefficient (ICC). Bland-Altman analysis assessed 95% limits of agreement and correlation coefficient (
r
) determined the strength of the relationship between measurements.

RESULTS:

The Pentacam AXL Wave had Sw for keratometry of 0.12 in the normal group and 0.15 in the keratoconus group and lower (poorer) Sw of 0.17 in the CXL group. For pachymetry, Sw was 9.18, 9.53, and 10.11 in the normal, keratoconus, and CXL groups, respectively. Total aberrations had ICCs ranging from 0.88 for RMS HOAs to 0.95 for SA in the normal group, 0.86 for RMS HOAs to 0.92 for SA in the keratoconus group, and 0.72 for RMS HOAs to 0.82 for SA (poorer) in the CXL group. In the normal group, mean differences between the two devices were nonsignificant for all parameters except SA (0.011 ± 0.038 μm,
P
< .01; limits of agreement = −0.09 to 0.07;
r
= 0.87). In the keratoconus group, mean differences were significant in all aberrations except RMS LOAs (−0.27 ± 0.85 μm,
P
= .10; limits of agreement = −3.3 to 3.8;
r
= 0.92). In the CXL group, all parameters varied significantly (
P
< .006).

CONCLUSIONS:
The Pentacam AXL Wave showed comparable repeatability in the normal and keratoconus groups, but was poorer in the CXL group, more so with increasing corneal haze. Both devices can be used interchangeably in normal eyes, except for SA, but not in eyes with keratoconus or CXL for aberration measurements.

[
J Refract Surg
. 2022;38(3):201–208.]
Therapeutic Small Interfering RNA Targeting Complement C3 in a Mouse Model of C3 Glomerulopathy
Authors: Zanchi Cristina , Locatelli Monica , Cerullo Domenico , Aumiller Verena , Corna Daniela , Rottoli Daniela , Eisermann Mona , Donadelli Roberta , Mousavi Mansoureh , Noris Marina , Remuzzi Giuseppe , Benigni Ariela , Zoja Carlamaria 
Published: March 2022

Abstract
Alternative pathway complement dysregulation with abnormal glomerular C3 deposits and glomerular damage is a key mechanism of pathology in C3 glomerulopathy (C3G). No disease-specific treatments are currently available for C3G. Therapeutics inhibiting complement are emerging as a potential strategy for the treatment of C3G. In this study, we investigated the effects of N-acetylgalactosamine (GalNAc)–conjugated small interfering RNA (siRNA) targeting the C3 component of complement that inhibits liver C3 expression in the C3G model of mice with heterozygous deficiency of factor H (Cfh+/− mice). We showed a duration of action for GalNAc-conjugated C3 siRNA in reducing the liver C3 gene expression in Cfh+/− mice that were dosed s.c. once a month for up to 7 mo. C3 siRNA limited fluid-phase alternative pathway activation, reducing circulating C3 fragmentation and activation of factor B. Treatment with GalNAc-conjugated C3 siRNA reduced glomerular C3d deposits in Cfh+/− mice to levels similar to those of wild-type mice. Ultrastructural analysis further revealed the efficacy of the C3 siRNA in slowing the formation of mesangial and subendothelial electron-dense deposits. The present data indicate that RNA interference–mediated C3 silencing in the liver may be a relevant therapeutic strategy for treating patients with C3G associated with the haploinsufficiency of complement factor H.
Trends in Pediatric Anterior Cruciate Ligament Reconstruction: The Effect of COVID-19
Authors: Kiani Sara N. , Yellin Joseph L. , Houlihan Nathan V. , Talwar Divya , Shea Kevin G. , Ganley Theodore J. 
Published: March 2022

Context
The number of pediatric anterior cruciate ligament reconstructions (ACLRs) occurring yearly increased almost 6-fold from 2004–2014. We find it interesting that limited recent data exist on rates of ACL injury and reconstruction in children and adolescents, especially in the context of COVID-19.

Objective
Given the effect of the COVID-19 pandemic on youth sports seasons and the postponement of many elective surgeries, we sought to examine the changes in rates of ACLR during this period.

Design
Retrospective cohort study.

Setting
This study used the Pediatric Health Information System (PHIS) database to identify eligible patients at PHIS-participating hospitals nationwide from January 2016–June 2021, with March 1, 2020, considered the start of the COVID-19 pandemic.

Patients or Other Participants
Using Current Procedural Terminology codes, patients 18 years old and younger who underwent ACLR surgery were identified.

Main Outcome Measure(s)
Patient demographics and overall rates of surgery prepandemic and intrapandemic were compared. Data were analyzed using bivariate, mixed-model, and time series analyses.

Results
A total of 24 843 ACLRs were identified during this time period. In total, 1853 fewer surgeries than expected were performed after March 2020 given prepandemic trends. Intrapandemic demographics revealed an increase in the proportion of patients who identified as White and with private insurance and a decrease in the proportion who identified as Black and with public insurance. Also, the proportion of ACLRs by region shifted, with more surgeries performed in the Midwest and fewer in the Northeast. In the model adjusted for hospital-level variability, only race and insurance status remained significant.

Conclusions
Based on prepandemic trends, fewer patients than projected underwent ACLR once the pandemic began, likely due to a combination of decreased rates of injury and delayed surgery.
Hexadecanoic acid-enriched extract of Halymenia durvillei induces apoptotic and autophagic death of human triple-negative breast cancer cells by upregulating ER stress
Authors: Sangpairoj Kant , Settacomkul Rapeewan , Siangcham Tanapan , Meemon Krai , Niamnont Nakorn , Sornkaew Nilubon , Tamtin Montakan , Sobhon Prasert , Vivithanaporn Pornpun 
Published: March 2022

Objective:
To investigate the effect of the hexane solvent fraction of Halymenia durvillei (HDHE) on triple-negative breast cancer.

Methods:
The phytochemical profile of HDHE was investigated by GC-MS. The cytotoxicity of HDHE against MDA-MB-231 cells was determined. The apoptotic and autophagic effects of HDHE were analyzed. The expression of molecular markers controlling apoptosis, autophagy, DNA damage, and endoplasmic reticulum (ER) stress was determined.

Results:
HDHE contains a mixture of fatty acids, mainly hexadecanoic acid. HDHE at a cytotoxic concentration induced apoptotic death of MDA-MB-231 cells through mitochondrial membrane dysfunction, and induction of apoptosis markers, and increased the expression of proteins related to DNA damage response. HDHE also induced the expression of LC-3, a marker of autophagic cell death at a cytotoxic concentration. Moreover, HDHE modulated the expression of ER stress genes.

Conclusions:
The hexadecanoic acid-enriched extract of Halymenia durvillei promotes apoptosis and autophagy of human triple-negative breast cancer cells. This extract may be further explored as an anticancer agent for triple-negative breast cancer.
Sex variation of central serous chorioretinopathy by spectral domain optical coherence tomography
Authors: Amer Ahmed A.A. 
Published: March 2022

Purpose
The aim of this study was to compare the spectral domain optical coherence tomography (SD-OCT) characteristics of central serous chorioretinopathy (CSR) between male and female patients.

Patients and methods
This is a retrospective study that included 39 patients of both sexes diagnosed as CSR during the period between January 2018 and May 2020. The analyzed data included patients’ age, duration of symptoms, and the SD-OCT measurable parameters in the male and female patient groups. The SD-OCT parameters included central total retinal thickness, central sensory retinal thickness, vertical distance of subfoveal subretinal fluid, horizontal distance of subfoveal subretinal fluid, and the presence of subretinal deposits. These parameters were compared and statistically analyzed between the two groups.

Results
The study included 24 male patients and 15 female patients. The mean age was 35.33±9.88 years in the male group and 41.53±8.28 years in the female group (P=0.05). In the male group, central total retinal thickness, central sensory retinal thickness, vertical distance of subfoveal subretinal fluid, and horizontal distance of subfoveal subretinal fluid were 448±93 μm, 182±34 μm, 305±53 μm, and 3.07±0.63 mm, respectively, while in the female group, they were 346±127 μm (P=0.006), 178±34 μm (P=0.73), 244±61 μm (P=0.002), and 2.34±0.67 mm (P=0.001), respectively. The percentage of patients having subretinal deposit was significantly more in the male group than in the female group (P=0.003).

Conclusions
There was a statistically significant difference in SD-OCT characteristics of CSR between male and female patients. Further studies are needed regarding the persistence of these OCT differences after treatment of CSR.
Facilitated delivery of topical steroids after fractional ablative carbon dioxide laser benefits postthyroidectomy hypertrophic scar
Authors: Lin Cen-Hung , Tsai Yueh-Ju , Chi Shun-Yu , Hsieh Mu-Han , Lin Ko-Chien , Lin Hui-Ping , Hsu Shiun-Yuan , Tsai Hui-Hong , Hsieh Ching-Hua 
Published: March 2022

Background:
Thyroidectomy results in unsightly scarring at the anterior neck of the patient.

Objectives:
This prospective clinical study aimed to assess the effectiveness of laser assisted drug delivery (LADD) of topical steroid ointment for the treatment of postthyroidectomy hypertrophic scars.

Methods:
Five courses of a fractional ablative carbon dioxide laser combined with topical 0.05% clobetasol propionate were applied every 4 weeks to treat postthyroidectomy hypertrophic scars in ten adult female patients. The effectiveness was assessed by the patient themselves according to the Patient and Observer Scar Assessment Scale (POSAS) and by three different doctors according to photography evaluations before and 1 year after the first treatment.

Results:
Assessments of the scars by POSAS revealed significant improvements in terms of itchiness, color, softness, thickness, irregularity, and distorted appearance of the scars, albeit without any significant pain relief. In addition, all indicative characteristics of the scar, namely, vascularity, pigmentation, thickness, relief, pliability, surface area, and overall opinion, as assessed by the treating doctor and based on photographic evaluations by three different doctors, revealed significant improvements in the scars after treatment.

Conclusion:
In this study, we demonstrated that the topical delivery of steroids after fractional ablative carbon dioxide laser treatment showed an encouraging outcome in postthyroidectomy hypertrophic scarring.
Description of a new endemic genus of the Namib Desert and adjacent biomes in Namibia (Tineoidea: Tineidae: Hapsiferinae)
Authors: Mey Wolfram , Léger Théo 
Published: March 2022

The genus Rooiklipia gen. nov. is established to accommodate four species, collected in the Namibia: R. michaelmeyi spec. nov., R. neufferae spec. nov., and R. vanbiljoni spec. nov. Described from the Namib, R. mirabib (Mey, 2011) comb. nov. is the type species and is transferred from Rhodobates Ragonot, 1895 to the new taxon. The male and female genitalia, wing venation, adult moths, and distribution are illustrated. The species can be distinguished by small but constant differences in the male and female genitalia. The validity of the species is supported by molecular studies. Rooiklipia gen. nov. is placed in Hapsiferinae.
Mengaktualisasikan Sila Ketiga Pancasila dalam Perspektif Iman Kristen: Refleksi Teologis tentang Kerukunan
Authors: Istinatun Hestyn Natal , Fernando Andreas , Anjaya Carolina Etnasari 
Published: March 2022

Aktualisasi sila ketiga Pancasila dalam kemajemukan masyarakat Indonesia merupakan suatu keniscayaan, di tengah ancaman disintegrasi bangsa. Dalam masyarakat majemuk dibutuhkan kerukunan sebagai fondasi demi terselenggaranya kehidupan yang damai sejahtera. Alkitab mengajarkan bahwa kerukunan adalah panggilan hidup yang harus dijalankan oleh setiap orang percaya. Tujuan dari penelitian ini adalah membuka pemahaman mengenai apa dan bagaimana tugas orang percaya dalam membangun kerukunan, dan bagaimana cara mengaktualisasikan sila ketiga Pancasila dalam hidup bermasyarakat yang sesuai dengan ajaran Alkitab. Penelitian ini menggunakan metode kualitatif deskriptif dengan pendekatan studi pustaka. Penulis menggali tema tentang kerukunan dan aktualisasi sila ketiga Pancasila dari berbagai literatur baik artikel jurnal, buku, maupun literatur lain. Dilakukan pula penggalian berbagai teks Alkitab yang menggambarkan bagaimana orang Kristen harus hidup memenuhi panggilan Tuhan dalam mewujudkan dan menjaga kerukunan. Hasil penelitian ini menyimpulkan bahwa aktualisasi sila ketiga dapat dilakukan dengan membangun kerukunan melalui spirit nasionalisme dan sikap patriotisme yang sesuai dengan ajaran Alkitab.
Liturgi yang Bermain untuk Generasi Z di Masa Pandemi COVID-19: Suatu Panduan Melalui Perspektif Romano Guardini
Authors: Tambun Tiarma Pintauli 
Published: March 2022

ABSTRAk: Pandemi COVID-19 menghantar gereja kepada pergumulan dengan dunia virtual, sekaligus kebosanan hidup dengan interaksi daring tersebut. Berbagai gereja dan sekolah berusaha untuk menyesuaikan diri dengan keadaan ini melalui berbagai usaha seperti menjalankan ibadah secara virtual via Zoom dan YouTube. Sayangnya, usaha penyelamatan itu tidak holistik mengarah kepada seluruh warga jemaat. Ibadah virtual kurang memberi perhatian pada generasi Z yang menghadapi kebosanan, kesepian, bahkan kemarahan dengan situasi pandemi, terlebih ketika mereka melewati masa-masa karantina. Pada dasarnya, generasi ini erat dengan bermain. Bermain pun menjadi bagian dari pendidikan (paedeia). Sejumlah teks Perjanjian Lama (Mzm. 33:21; Ams. 13:9; Pkh. 8:15; 2 Sam. 6:5; 1 Taw. 15:29; Zak. 8:5; Kel. 32:6) dan Perjanjian Baru (Kis. 2:26, Luk. 24:50-52) menghubungkan bermain dengan sukacita, kegembiraan, kebahagiaan, dan kesenangan. Dari problematika generasi Z dan sejumlah landasan teologis bermain yang mendatangkan sukacita, tulisan ini berupaya untuk mengonstruksi liturgi bermain bagi generasi Z yang kehilangan gairah ibadah virtual di masa pandemi. Penelitian ini menunjukkan bahwa liturgi bermain mampu memberi ruang bagi generasi Z untuk lebih interaktif dan aktif dalam ibadah. ABSTRACT: Pandemic COVID-19 led church to strive for a virtual world and living with some boredom due to the online interaction. Some churches and schools try to adjust themselves with these conditions by running the virtual service via Zoom and YouTube. However, this effort is not holistic for the whole people. Virtual worship is not paying attention enough to the Z generation who are facing boredom, loneliness, and anger due to the pandemic, especially during the quarantine. Basically, this generation is close to playful activity. Playful has been part of education (paidea). Some text in the Old Testament and the New Testament has connected playful with rejoiceful, happiness, joyful, and fun. From these Z generation’s problems and with the playful theology pedestal, this paper tries to construct playful liturgy for the Z generation who lost enthusiasm for virtual worship during the pandemic. This research has shown that playful liturgy is able to give a space for the Z generation to be more interactive and active in worship.
Menjadi Gereja yang Inklusif dalam Konteks Keberagaman berdasarkan Injil Matius 8:5-13
Authors: Pono Mefibosed Radjah 
Published: March 2022

This paper examines efforts to build an attitude of religious moderation through an inclusive church life through the meaning of Matthew 8:5-13. This study used an interpretive description method by interpreting the text of Matthew 8:5-13 to build an inclusive attitude as the basis for religious moderation. The result is a portrait of Jesus' ministry showing His universal love, and His mission is to serve all people including “others”. Jesus are receiving and serving all people, including Gentiles. Therefore, as evidence of the church's faith in Jesus is to have an open attitude to accept and serve all people, including the “others”. This is the basis for the church's inclusive attitude in building an attitude of religious moderation in the context of a pluralistic Indonesia. Tulisan ini mengkaji tentang upaya membangun sikap moderasi beragama melalui kehidupan gereja yang inklusif melalui pemaknaan terhadap Matius 8:5-13. Penelitian ini menggunakan metode deskripsi interpretatif dengan memaknai teks Matius 8:5-13 untuk membangun sikap yang inklusif sebagai dasar moderasi beragama. Hasilnya adalah potret pelayanan Yesus menunjukan kasih-Nya yang bersifat universal, dan misi-Nya adalah melayani semua orang termasuk “yang lain”. Yesus terbuka menerima dan melayani semua orang, termasuk orang-orang bukan Yahudi. Karena itu, sebagai bukti iman gereja kepada Yesus adalah memiliki sikap terbuka menerima dan melayani semua orang termasuk “yang lain”. Hal inilah yang menjadi dasar sikap inklusif gereja dalam membangun sikap moderasi beragama dalam konteks Indonesia yang plural.
PENGEMBANGAN SISTEM INFORMASI SIMPAN PINJAM PADA KOPERASI WREDATAMA KRAKATAU STEEL (KOPWEKAS)
Authors: Asrori Khasan , Darpi Darpi , Nurhayati Sawitri 
Published: March 2022

The main activity of cooperatives is to carry out savings and loan transactions for cooperative members only. Every transaction carried out at the Wredatama Krakatau Steel Cooperative (Kopwekas) already uses a database-based application that only requires a few problems including data collection on deposits, credit data collection, and payment processing as well as arrears of cooperative members. It is necessary to develop a savings and loan information system. The methodology used in the design of this information system is the Waterfall Method. This system is designed using the concepts of UML (Unifield Modeling Language) and implemented using Microsoft SQL Server 2000 Database, and Visual Basic 6.0. The expected result of this research is the development of a savings and loan information system of kopwekas which includes processing of deposits, credit, payments and arrears of cooperative members. By using this information system, it is also hoped that the reporting process will be easier, faster with accurate data.
Keywords: Information System, Savings and Loans, Waterfall, Cooperative
Some Results for $(s,m)$-convex Function in the Second Sense
Authors: SERTBAŞ Meltem , MİHYAZ İlknur 
Published: March 2022

Convex functions, like differentiable functions, have a important role in many fields of pure and applied mathematics. It connects concepts from topology, algebra, geometry and analysis, and is an important tool in optimization, mathematical programming and game theory. Also, inequalities for convex function has receives special attention by many researchers because the theory of convex functions has applications in different field of science like biology, economy and optimization.
In this paper, it is given some properties for an (s,m)-convex function defined on [0,d], d>0 in the first sense and the second sense with m\in (0,1). Also, some integral inequalities are examined for any non positive (s,m)-convex function in the second sense with any measure space.
Effective utilization of time for non –operating room anaesthesia services at Aga Khan University Hospital Karachi: a prospective quality improvement audit
Authors: Mohsin Nazir  , Azhar Rehman  , Rizwana shehzad  , Tanveer Baig  
Published: March 2022

Objective: To identify service quality gaps by reviewing out-of-operating-room anaesthesia services in a tertiary care hospital.
Method: This quality improvement audit was conducted at The Aga Khan University Hospital Karachi from July to September 2019, and comprised procedures conducted outside the operating room under anaesthesia and sedation from 8am to 5pm. A data collection form was designed to collect information related to the non-operating-room anaesthesia services. Data was analysed using SPSS Version 19.
Results: A total of 123 radiological procedures were observed in 48 working days and endoscopic/radio-therapeutic procedures observed were 98 over 31 days. The mean anaesthesia coverage time was 2.96±1.71 hours per day for radiological procedures, and 2.59±1.07 hours for endoscopic/radio-therapeutic procedures, indicating underutlisation of resources both human and material .
Conclusion:A multideciplinary team consisting of all stakeholders should be developed to facilitate the patients and enhance healthcare quality.
Key Words: Non-operating-room anaesthesia, NORA, Radiological procedures, Monitored anaesthesia care, Multideciplinary team.
Concrete technology. Chapter 2: Concrete Materials
Authors: De La Cruz Vega Sleyther Arturo , Mendoza Flores Cristian Milton , Pezo Morales Pablo Adrian , Garrido Oyola Jose Antonio , Ascoy Flores Kevin Arturo , Suclupe Sandoval Robert Edinson 
Published: March 2022

The following book chapter presents the essential components of concrete, being a material that can acquire any shape in the liquid state and is very resistant in the hardened state as well as being aesthetic to be used in a diversity of applications.
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