bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel diagnostic potential of miR-1 in patients with acute heart failure
Authors: Sadat-Ebrahimi Seyyed-Reza , Rezabakhsh Aysa , Aslanabadi Naser , Asadi Milad , Zafari Venus , Shanebandi Dariush , Zarredar Habib , Enamzadeh Elgar , Taghizadeh Hamed , Badalzadeh Reza 
Published: September 2022

Background
A number of circulating micro-ribonucleic acids (miRNAs) have been introduced as convincing predictive determinants in a variety of cardiovascular diseases. This study aimed to evaluate some miRNAs’ diagnostic and prognostic value in patients with acute heart failure (AHF).

Method
Forty-four AHF patients were randomly selected from a tertiary heart center, and 44 healthy participants were included in the control group. Plasma levels of assessed miRNAs, including miR -1, -21, -23, and -423-5-p were measured in both groups. The patients were followed for one year, and several clinical outcomes, including in-hospital mortality, one-year mortality, and the number of readmissions, were recorded.

Results
An overall 88 plasma samples were evaluated. There was no significant difference in terms of demographic characteristics between the AHF and healthy groups. Our findings revealed that mean levels of miR-1, -21, -23, and -423-5-p in AHF patients were significantly higher than in the control group. Although all assessed miRNAs demonstrated high diagnostic potential, the highest sensitivity (77.2%) and specificity (97.7%) is related to miR-1 for the values above 1.22 (p = 0.001, AUC = 0.841; 95%CI, 0.751 to 946). Besides, the levels of miR-21 and -23 were significantly lower in patients with ischemia-induced HF. However, the follow-up data demonstrated no significant association between miRNAs and prognostic outcomes including in-hospital mortality, one-year mortality, and the number of readmissions.

Conclusion
The result of our study demonstrated that miR-1, -21, -23, and -423-5-p can be taken into account as diagnostic aids for AHF. Nevertheless, there was no evidence supporting the efficacy of these miRNAs as prognostic factors in our study.
Eosinophilic Gastritis and Enteritis Are Increased in Families With Eosinophilic Esophagitis
Authors: Allen-Brady Kristina , Colletier Keegan J. , Woller Scott , Eliason Kyle , Uchida Amiko M. , Ro Gabrielle , Newman Mike , Peterson Kathryn A. 
Published: September 2022

INTRODUCTION:
There are limited data on the familial risk of distal eosinophilic gastrointestinal diseases (EGIDs) in patients with eosinophilic esophagitis (EoE). We analyzed the risk of eosinophilic gastritis/gastroenteritis (EG/EGE) and eosinophilic colitis (EC) as forms of distal EGIDs using International Disease Classification-9/10 codes in subjects with EoE and their relatives.

METHODS:
The Utah Population Database is a resource that links genealogy information and medical records in Utah. We identified EGIDs in probands and their first-degree (FDRs), second-degree (SDRs), and third-degree (TDRs) relatives in the Utah Population Database. Relative risk and 95% confidence intervals were estimated. All individuals with inflammatory bowel disorder were eliminated to avoid misdiagnosis with EGIDs.

RESULTS:
We included 8,455 subjects with EoE, 396 with EG/EGE, and 172 with EC. Probands with EoE were at increased risk of EG/EGE and EC. Risks of EG/EGE were increased among FDRs and SDRs of probands with EoE , even without concomitant EoE in the relatives. Increased risk of EG/EGE in FDRs and SDRs was also present for EoE probands without EG/EGE or EC. We observed no isolated familial aggregation of EG/EGE after excluding cases with comorbid EoE. EC probands without EoE were at increased risk of EG/EGE, but no evidence of familial risk of EC was observed.

DISCUSSION:
The relative risk of EG/EGE is significant among relatives of patients with EoE, suggesting that shared genetic factors exist among these EGIDs. EG/EGE and EC showed limited familial clustering, although sample sizes were small.
A compact breath gas sensor system based on terahertz/millimeter-wave gas spectroscopy
Authors: Rothbart Nick , Schmalz Klaus , Koczulla Rembert , Hübers Heinz-Wilhelm 
Published: September 2022

Abstract
We demonstrate a full-cycle breath gas sensor system based on terahertz/millimeter-wave gas spectroscopy. The sensor consists of a transmitter and receiver working around 250 GHz based on SiGe BiCMOS technology. Typical detection thresholds are in the ppm range depending on the respective molecule. The data analysis provides partial pressures of the investigated molecules by fitting of spectra which are measured by wavelength modulation. Beside the spectroscopic measurement and the data analysis, a full cycle of breath analysis includes the sampling and the conditioning of the sample tubes. The full cycle takes about 35 min per sample in average. As the system is compact and easy to operate, it allows for on-site analysis of breath samples in medical laboratories or hospitals.
Endophytic bacterial strain,Brevibacillus brevis-mediated green synthesis of copper oxide nanoparticles, characterization, antifungal,in vitrocytotoxicity, and larvicidal activity
Authors: Fouda Amr , Hassan Saad El-Din , Eid Ahmed M. , Awad Mohamed A. , Althumayri Khalid , Badr Naglaa Fathi , Hamza Mohammed F. 
Published: September 2022

AbstractThe biomass filtrate containing various metabolites of endophytic bacterial strain,Brevibacillus brevisPI-5 was used as a biocatalyst for reducing and stabilizing copper oxide nanoparticles (CuO-NPs). UV-Vis spectroscopy, Fourier transform infrared, transmission electron microscopy, scanning electron microscopy with energy-dispersive X-ray (SEM-EDX), X-ray diffraction, and X-ray photoelectron spectroscopy were used for CuO-NPs characterization. A spherical, well-dispersed, and crystallographic structure with sizes of 2–28 nm was formed. The SEM-EDX confirmed the presence of Cu and O with weight percentages of 27.62% and 48.88%, respectively. The biological activities including antifungal, anticancer, and larvicidal of synthesized CuO-NPs were assessed using the fungal radial growth inhibition, MTT assay method, and mortality percentages, respectively. The obtained data showed that the CuO-NPs exhibit high activity in a dose-dependent manner. The growth of three phytopathogenic fungi,Fusarium oxysporum, Alternaria alternata, andAspergillus nigerwas decreased by percentages of 64.5% ± 4.1%, 62.9% ± 0.3%, and 70.2% ± 2.3%, respectively at 300 µg·mL–1. Also, various clinicalCandidaspp. were successfully inhibited with varied zones of inhibition and minimum inhibitory concentration values in ranges of 6.25–50 µg·mL–1. Thein vitrocytotoxicity exhibits target-orientation to breast cancer cells (T47D) at low concentration compared to normal cells (HFB4) with IC50values of 122.3 ± 5.4 and 229.9 ± 5.7 μg·mL–1, respectively. The mortality percentages of I, II, III, and IV instar larvae ofCulex antennatuswere 60% ± 1.4%, 43.1% ± 1.1%, 36.2% ± 1%, and 32.1% ± 0.9%, at 10 mg·L–1and increased to 86.9% ± 2.1%, 68.1% ± 1.7%, 64.4% ± 1.9%, and 53.1% ± 1.4% at 50 mg·L–1, respectively.
Laughing alone and laughing together in panel meetings: laughter as an interactional accomplishment during negotiation talks
Authors: Icbay Mehmet Ali , Koschmann Timothy 
Published: September 2022

AbstractThis paper is about the interactional organization of shared laughter in a multi-party institutional setting. It explored how laughter was produced and shared in a series of panel meetings in a medical school. The audio data were taken from Competency Project, a NIHM-funded (National Institute of Mental Health) research designed to investigate how the judgments of professional competence in medical schools were constructed. In the panel meetings, a group of three panelists (physician-instructors) gathered together and came to an agreement for the medical students’ performances with the standard patients. While they negotiated their individual ratings, the panelists repeatedly laughed. Finding its interest in these repeated laughs, this study first displayed how laughter was produced and shared in a formal institutional setting. The second section in the paper gave a detailed account of the three cases where at least a panelist in the meetings did not join in the shared laughter sequences. The closer look at these cases suggested that when at least a panelist did not participate in the shared laughter, (1) the non-laughing panelists were mitigating the tension rooted in the disagreement on the negotiated rating, or (2) they were postponing their laugh to create a follow-up laughable, or (3) due to the conflict on the individual ratings, they were teased by the other panelists.
The crystal structure of (Z)-6-(((5-chloro-2-hydroxyphenyl)amino)methylene)- 4-nitrocyclohexa, C13H9ClN2O4
Authors: Zhang Zhijian , Xiao Xiyuan , Jiang Wujiu , Feng Hao 
Published: September 2022

Abstract
C13H9ClN2O4, monoclinic, P21/n (no. 14), a = 11.1882(11) Å, b = 8.0672(8) Å, c = 14.0813(15) Å, β = 94.084(2)°, V = 1267.7(2) Å3, Z = 4, R

gt
(F) = 0.0427, wR

ref
(F
2) = 0.1104, T = 296(2) K.
Liquation Cracking in Linear Friction Welded Directionally Cast Alloy 247
Authors: Neidel A. , Giller M. , Riesenbeck S. 
Published: September 2022

Abstract
Linear Friction Welding (LFW) is a rarely used joining technology. To test the suitability of this solid-state process for hot cracking-sensitive nickel base superalloys, tests were performed using conventionally and directionally cast slabs of Alloy 247. Since LFW does not involve melting of the weld flanks, there were some expectations that this special welding technique could overcome the poor weldability of Alloy 247. However, all tested specimens failed by liquation cracking (LC) within the Weld Center Zone (WCZ) at the directionally cast side.
Politeness of nonverbal hospitality in Saudi and British female interactions
Authors: Almusallam Inas I. 
Published: September 2022

AbstractAlthough linguistic politeness has been extensively theorized about, the role of nonverbal behaviour in managing politeness in interactions has been neglected until recently. In this analysis of natural conversations between female friends in dinner settings, I show how nonverbal hospitality can influence rapport management and the constructionist nature of politeness among Saudi and British female friends, and I compare the two cultures. I show how these nonverbal acts can be observed by looking at the sequences and turns taken in talking, exploring metapragmatic evaluations, and using second-order politeness concepts in interpreting politeness as situated in discourse. The combination of these analytical tools allows for an explanation of what is going on rather than a mere description of the interaction. The analysis demonstrates that nonverbal hospitality plays an important role in the management of rapport and discursive relations. I find that, although the motivation and role of nonverbal hospitality in the management of interactions in young female friendship groups in the two cultures are similar, there are remarkable differences in frequency, reactions, and complexity in the negotiation of nonverbal hospitality.
Biochar: its characteristics application and utilization of on environment
Authors: Ganesan Subbulakshmi , Padmapriya G. , Omoikhoje Izegaegbe Daniel , Tharudini J.H. , De Zoysa Sanduni Anupama 
Published: September 2022

Abstract
There are a variety of organic waste feedstocks that may be used to make biochar, such as agricultural byproducts and municipal solid waste. Biochar’s distinctive properties, such as its high carbon content and cation exchange capacity, large specific outer area, and stable structure, have attracted increased interest. The purpose of this study was to offer an overview of biochar with a focus on its environmental application by methodically analyzing and summarizing research on its production, characterization, modification, and the utilization in this review. Based on the kind of feedstocks used, the Biochar’s physiochemical characteristics might vary greatly. A variety of processes are used to create biochar, including pyrolysis, gasification, and hydrothermal carbonization. Acidic, alkaline, oxidizing agent, carbonaceous materials, steam and gas purging may be used to alter biochar. The environment field of application influences the adoption of modification methods. Soil remediation and improvement, carbon sequestration, composting of organic solid waste, water and wastewater purification, catalyst and activator, electrode materials and electrode modification are all examples of applications for biochar. In order to get consistent results, additional research into the use of biochar in carbon sequestration is needed. Soil microorganisms and biochar should be studied further to determine the primary cause of increased soil fertility in various soils and feedstocks. When biochar is utilized for environment remediation, further consideration must be given to the release of heavy metals and PAHs from biochar into the environment. To further understand how biochar works as an activator for per sulfate, more research into the link between biochar structure and activation capabilities is needed. There are several environmental remediation applications for biochar, and greater research is needed to understand its mode of action.
Dissociation between Attention-Dependent and Spatially Specific Illusory Shape Responses within the Topographic Areas of the Posterior Parietal Cortex
Authors: Arsenovic Ana , Ischebeck Anja , Zaretskaya Natalia 
Published: September 2022

The human visual system consists of multiple topographic maps that extend from the early visual cortex (EVC) along the dorsal and ventral processing streams. Responses to illusory shapes within these maps have been demonstrated in the ventral stream areas, in particular the lateral occipital complex (LOC). Recently, the intraparietal sulcus (IPS) of the dorsal stream has been linked to the processing of illusory shapes defined by motion. It remains unclear whether the topographically organized parietal areas also respond to stationary illusory shapes, which would suggest their generic role in representing illusory content. In the current study we measured brain responses using fMRI while 30 human participants (12 male) observed flickering inducers around the fixation task. The inducers either formed an illusory diamond in the center, a triangle in the left or right hemifield, or were inverted such that no illusory figure was formed. We compared responses of parietal regions IPS0-IPS5 and SPL1 to each illusory figure with the nonillusory condition. To determine the role of attentional modulation on illusory shape responses we manipulated the difficulty of the fixation task. Our results show that all IPS areas responded to illusory shapes. The more posterior areas IPS0–IPS3 additionally displayed a preference toward contralateral shapes, while the more anterior areas IPS4 and IPS5 showed response attenuation with increased task difficulty. We suggest that the IPS can represent illusory content generated not only by moving, but also by stationary stimuli, and that there is a functional dissociation between attention-dependent anterior and spatially specific posterior topographic maps.SIGNIFICANCE STATEMENTThe traditional view of the ventral visual pathway being solely responsible for representation of objects has recently been challenged by demonstrating illusory shape representation within the dorsal visual pathway with moving bistable stimuli. Our results provide evidence for the dorsal stream contribution to representing not only moving, but also stationary illusory shapes. Our results also show a functional subdivision along the topographic maps, with spatially specific shape responses in the more posterior, and attention-dependent responses in the more anterior areas. These findings have implications for our understanding of the relationship between attention and grouping in healthy individuals and neuropsychological patients. Furthermore, IPS areas should be considered in theoretical accounts and models of how subjective content is generated in the brain.
Method development and validation for simultaneous determination of Eletriptan hydrobromide and Itopride hydrochloride from fast dissolving buccal films by using RP-HPLC
Authors: Siddique Waqar , Sarfraz Rai Muhammad , Zaman Muhammad , Khan Riffat , Gul Maria , Asghar Farhan , Malik Tangina , Saif Asiya , Shamim Qurat-Ul-Ain , Salawi Ahmad , Alshamrani Meshal , Almoshari Yosif , Sabei Fahad Y. 
Published: September 2022

AbstractOne of the most effective, rapid, and simple methods reversed-phase high-performance liquid chromatography (RP-HPLC) was used for simultaneous development and validation of Eletriptan hydrobromide (ELE HBR) and Itopride hydrochloride (ITP HCL) in combination. The method was validated based on the regulations of United States Pharmacopeia (USP) and International Conference on Harmonization (ICH) guidelines. Separation of both drugs was achieved within approximately 5 min by using a mobile phase made up of a 70:30 ratio of phosphate buffer and acetonitrile having a flow rate of 1 mL min−1. Furthermore, a comprehensive study was conducted on precision, accuracy, linearity, inter-day, intra-day studies, an assay of formulated films, and stability studies of combined prepared film. Co-efficient of correlation ranged between 0.9993, and 0.9965 for ELE HBR and ITP HCL respectively. The accuracy of the developed method was accurate as drug recoveries in both cases of ITP HCL, and ELE HBR falls between (99.87, 99.96, and 99.84%) to (99.81, 99.12, and 98.44%) respectively having a concentration range of solutions between 10, 30 and 50 μg mL−1 dilution. Films developed by using both drugs in combination were then validated for assay studies, and it was found that substantial results of 99.05%, and 99.87% were found in the case of ITP HCL and ELE HBR respectively. The stability of the solution and mobile phase showed the method's accuracy as the results were 97% for ITP HCL and 99% for ELE HBR. The proposed method developed for simultaneous determination of ITP HCL and ELE HBR was developed and validation and no interaction of any excipient were found.
PSO-based optimized neural network PID control approach for a four wheeled omnidirectional mobile robot
Authors: Al-Jodah Ammar , Abbas Saad Jabbar , Hasan Alaq F. , Humaidi Amjad J. , Mahdi Al-Obaidi Abdulkareem Sh. , AL-Qassar Arif A. , Hassan Raaed F. 
Published: September 2022

AbstractThe demand for automation using mobile robots has been increased dramatically in the last decade. Nowadays, mobile robots are used for various applications that are not attainable to humans. Omnidirectional mobile robots are one particular type of these mobile robots, which has been the center of attention for their maneuverability and ability to track complex trajectories with ease, unlike their differential type counterparts. However, one of the disadvantages of these robots is their complex dynamical model, which poses several challenges to their control approach. In this work, the modeling of a four-wheeled omnidirectional mobile robot is developed. Moreover, an intelligent Proportional Integral Derivative (PID) neural network control methodology is developed for trajectory tracking tasks, and Particle Swarm Optimization (PSO) algorithm is utilized to find optimized controller's weights. The simulation study is conducted using Simulink and Matlab package, and the results confirmed the accuracy of the proposed intelligent control method to perform trajectory tracking tasks.
Modulation of the intestinal microbiota impacts the efficacy of immunotherapy in cancer patients – A recent literature survey
Authors: Ziegler Stella , Bereswill Stefan , Heimesaat Markus M. 
Published: September 2022

Abstract
In line with the current development of individualized cancer treatments, targeted and specialized therapeutic regimens such as immunotherapy gain importance and factors improving its efficacy come into the focus of actual research. Given the orchestrated interaction of the intestinal microbiota with host immunity the modulation of the human gut microbiota represents a therapy-enhancing factor. We therefore performed an actual literature survey on the role of the gut microbiota composition and the effects of its modification during immunotherapy of cancer patients. The included 23 studies published in the past 10 years revealed that both, distinct bacterial species and genera including Faecalibacterium prausnitzii and Bifidobacterium, respectively, enhanced distinct immunotherapy responses following PD-1/PD-L1 and CTLA-4 blockage, for instance, resulting in a better clinical outcome of cancer patients. Conversely, a high intestinal abundance of Bacteroidetes and Fusobacterium species correlated with a less efficient immunotherapy resulting in shorter progress-free survival outcomes. In conclusion, modifications of the gut microbiota by fecal microbiota transplantation or application of probiotic compounds represent potential adjunct options for immunotherapy in cancer patients which needs to be further addressed in future trials to provide individually tailored and safe adjuvant therapeutic measures in the combat of cancer.
Anthropological Engagements with Global Health
Authors: Medeiros Priscilla , Oliphant Allyson , Farrow Steven , Gill Priyanka 
Published: September 2022

Epidemic infectious diseases like HIV/AIDS, tuberculosis, Ebola, and more recently COVID-19, have persistent and devastating impacts in human populations across the globe. In this Review essay, we consider together the monographs Epidemic Illusions (Richardson 2021) and Fevers, Feuds, and Diamonds (Farmer 2020), as well as the documentary film Bending the Arc (Davidson and Kos 2017), Together, they demonstrate the history of transnational colonialism, the significance of structural violence as a contributor to global health inequity, and the increasing presence of co-occurring epidemics worldwide, topics which are often absent from discussions of global health systems. These three works discuss epidemics as pathologies of history and sociocultural patterns of colonial dispossession in global health systems; the inclusion of patient narratives in two of them, the film Bending the Arc and the book Fevers, Feuds, and Diamonds, is pivotal in describing the intricacies of HIV infection and other infectious diseases, as well as the complexity of gaining control of syndemic diseases. Further, these three materials point to the importance of health education in communities and of access to healthcare by community members, and to the roles that health education and access play in health policy implementation.