bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on Land Use in Towns from the Perspective of Ecological Security: a case study of Zhongtai Town, China
Authors: XU L. H. , XU D. , GU Z. F. , MA Q. W. , SHI Y. J. , WU Y. Q. 
Published: December 2022

Abstract
Context

Maintaining regional ecological security is necessary to ensure sustainable human survival and development. Starting with the goal of ecological security, optimal strategies for land use zoning can be developed. Previous studies have mainly focused on identifying ecological sources and ecological corridors, but the importance of ecological security in optimizing urban land use is seldom explored. In this study, a novel strategy for optimizing ecological security patterns (ESP) was proposed.

Objectives

To examine how to realize the zoning control of land use based on ESP .

Methods

We used an ESP model based on an ecological sensitivity evaluation, rain and flood models, MCR (Minimal Cumulative Resistance) model, and gravity model. Using these tools. And we assessed the ecological restoration, development, and construction of Zhongtai and proposed an optimized land use zoning management strategy.

Results

The establishment of the ESP of Zhongtai allowed for the characterization of the circulation of ecological sources in the region. This revealed 10 ecological sources, 9 important corridors, and 12 ordinary corridors. Recently, the study area has undergone a significant population increase and a rapid increase in urban land. But these built-up lands are concentrated in flood prone areas. Therefore, the construction of disaster prevention infrastructure should be prioritized during urban planning. Notably, the ecological corridors were mainly composed of tea plantations, farm land, mining land, and forest land, accounting for 80.45% of the total area. Ecological recovery can be carried out by mixed planting, returning farmland to forest, and prohibiting mining. In total, 71 ecological patches for restoration were identified, these were mostly mine lands flagged for restoration, but some were tea plantation optimization and illegal construction demolition areas. 61 controlled construction blocks were identified where strategies for ecological protection and food security should be applied, with priority use given to wastelands.

Conclusions

The ultimate goal of the study was to propose an optimized plan for controlled zoning of land use. Based on the ecological security and ecological sensitivity of the study area, four control zones were established: core protection area, ecological control area, restricted construction area, and suitable construction area. This controlled zoning strategy puts forward a clear management plan that ensures ecological protection and ecological restoration with optimal configurations and controlled construction designed to improve human health and livelihoods.
Robot-Assisted Lateral Pelvic Lymph Node Dissection in Patients with Advanced Rectal Cancer: A Single-center Experience of 65 Cases
Authors: Kim Eon Bin , Yoon Yong Sik , Kim Min Hyun , Kim Young Il , Lee Jong Lyul , Kim Chan Wook , Park In Ja , Lim Seok-Byung , Yu Chang Sik , Kim Jin Cheon 
Published: December 2022

Abstract
The treatment of lateral pelvic lymph node (LPLN) metastasis of rectal cancer has evolved because of technical difficulties from open surgery to laparoscopy and, recently, robot-assisted surgery. This study aimed to evaluate the technical feasibility and short- and long-term outcomes of robot-assisted LPLN dissection (LPND) following total mesorectal excision (TME) in advanced rectal cancer. Clinical data of 65 patients who underwent robotic-assisted TME with LPND from April 2014 to July 2022 were reviewed. Data regarding operative details, postoperative morbidity (within 90 postoperative days) for short-term outcomes and lateral recurrence as long-term outcomes were analyzed. Among the 65 patients with LPND, preoperative chemoradiotherapy was performed in 49 (75.4%). The mean operative time was 306.8 (range, 191–477) min, and the mean time of unilateral LPND was 38.6 (range, 16–66) min. LPND was bilaterally performed in 19 (29.2%) patients. The mean number of each side of harvested LPLNs was 6.8. Lymph node metastasis was observed in 15 (23.0%) patients, and 10 (15.4%) patients had postoperative complications. Lymphocele (n = 3) and pelvic abscess (n = 3) were the most common, followed by voiding difficulty, erectile dysfunction, obturator neuropathy, and sciatic neuropathy (all n = 1). During the 25 months of median follow-up, no lateral recurrence of the LPND site was noted. Robot-assisted LPND following TME is safe and feasible and showed acceptable short- and long-term outcomes. Despite some study limitations, we may be able to apply this strategy more widely through subsequent prospective controlled studies.
Genetic Algorithm based Approach to Solve the Clustered Steiner Tree Problem
Authors: Do Tuan Anh , Ban Ha-Bang , Huynh Thi Thanh Binh , Le Minh Tu , Nguyen Binh Long 
Published: December 2022

Abstract
In a complex network application, a set of nodes might be partitioned into multiple local clusters with different functions, properties, or communication protocols, and the communication is restricted between nodes of the same cluster to maximize efficiency and other security concern. Thus, there has been a rise in network design problems with additional constraints regarding the clustering of vertices, one of them being Clustered Steiner Tree Problem - a variant of the Steiner Tree Problem. Recently, a heuristic-based algorithm was proposed to solve the problem. However, its obtained result is limited in terms of solution quality when applied to the problem in the Euclidean case. This paper proposes a Genetic Algorithm called Shortest-Path Genetic Algorithm for solving the CluSteiner. In the proposal, a permutation-based individual representation that reduces the dimensionality of chromosomes to the number of clusters is devised. The proposed algorithm can solve the problem in both Euclidean and non-Euclidean cases. Experiment results compared to existing works in the literature are analyzed in detail to prove the effectiveness of the proposed algorithm.
The effect of six weeks of concurrent training (endurance-resistance) on the performance of the cardio-respiratory system in inactive young women
Authors: jabbari aysan , Gazalian farshad 
Published: December 2022

Abstract

Introduction: Inactive lifestyle is associated with decreased cardiorespiratory function and increased chronic non-communicable diseases and death. The aim of this study was to investigate the effect of six weeks of concurrent training (endurance-resistance) on the performance of the cardio-respiratory system in inactive young women.
Method: In this quasi-experimental study, 16 inactive women of Tehran city were selected in a targeted and available manner and were randomly placed in two control groups (n = 8) and concurrent exercise (endurance and resistance) (n = 8). After the pre-test (anthropometric tests and gas analyzer), the concurrent exercise group (endurance and resistance) performed the concurrent exercise program for six weeks and three sessions every week, and the subjects of the control group did not have any special exercise. After the six-week training period, measuring anthropometric indices (body mass index (BMI), body fat percentage (PBF), muscle mass (SMM) and hip-to-waist ratio (WHR) and cardiorespiratory indices including (the first ventilatory threshold (VE/VO2), Second ventilatory threshold (VE/VCO2), maximum oxygen consumption (VO2max), respiratory exchange ratio (RER), heart rate (HR), forced vital capacity (FVC), forced expiratory volume in one second (FEV1), expiratory volume forced in one second to forced capacity (FEV1/FVC) and the ratio of oxygen consumption to heart rate (VO2/HR) was done using in-body device and gas analyzer. The data were analyzed by covariance analysis test at the P<0.05.
Results: The results showed that six weeks of concurrent training (endurance-resistance) had no significant effect on the values ​​of VO2max, FEV1, FVC, VE/VO2, VE/VCO2, FEV1/FVC, VO2/HR,HR in inactive young women (P<0.05). Also, after the training period, there was no difference in BMI, PBF, SMM and WHR indices between the training and control groups (P<0.05).
Conclusion: According to the results of the research, it seems that six weeks of concurrent training (endurance-resistance) does not affect the performance of the cardio-respiratory system in inactive young women.
A FHIR has been lit on gICS – Facilitating the standardized exchange of informed consent in a large network of university medicine
Authors: Bialke Martin , Geidel Lars , Hampf Christopher , Blumentritt Arne , Penndorf Peter , Schuldt Ronny , Moser Frank-Michael , Lang Stefan , Werner Patrick , Stäubert Sebastian , Hund Hauke , Albashiti Fady , Gührer Jürgen , Prokosch Hans-Ulrich , Bahls Thomas , Hoffmann Wolfgang 
Published: December 2022

Abstract
Background

The Federal Ministry of Education and Research of Germany (BMBF) funds a network of university medicines (NUM) to support COVID-19 and pandemic research at national level. The “COVID-19 Data Exchange Platform” (CODEX) [1] as part of NUM establishes a harmonised infrastructure that supports research use of COVID-19 datasets. The broad consent (BC) of the Medical Informatics Initiative (MII) is agreed by all German federal states and forms the legal base for data processing. All 34 participating university hospitals (NUM sites) work upon a harmonised infrastructural as well as legal basis for their data protection-compliant collection and transfer of their research dataset to the central CODEX platform.
Each NUM site ensures that the exchanged consent information conforms to the already-balloted HL7 FHIR consent profiles and the interoperability concept of the MII Task Force “Consent Implementation” (TFCI).
The Independent Trusted Third-Party (TTP) of the University Medicine Greifswald supports data protection-compliant data processing and provides the consent management solutions gICS.

Methods

Based on a stakeholder dialogue a required set of FHIR-functionalities was identified and technically specified supported by official FHIR experts. Next, a “TTP-FHIR Gateway” for the HL7 FHIR-compliant exchange of consent information using gICS was implemented. A last step included external integration tests and the development of a pre-configured consent template for the BC for the NUM sites.

Results

A FHIR-compliant gICS-release and a corresponding consent template for the BC were provided to all NUM sites in June 2021. All FHIR functionalities comply with the already-balloted FHIR consent profiles of the HL7 Working Group Consent Management. The consent template simplifies the technical BC rollout and the corresponding implementation of the TFCI interoperability concept at the NUM sites.

Conclusions

This article shows that a HL7 FHIR-compliant and interoperable nationwide exchange of consent information could be built using of the consent management software gICS and the provided TTP-FHIR Gateway. The initial functional scope of the solution covers the requirements identified in the NUM-CODEX setting. The semantic correctness of these functionalities was validated by project-partners from the Ludwig-Maximilian University in Munich. The production rollout of the solution package to all NUM sites has started successfully.
Modeling monthly actual evapotranspiration: an application of geographically weighted regression technique in the Passaic River Basin
Authors: Oteng Mensah Felix , Alo Clement Aga 
Published: December 2022

Abstract
Actual evapotranspiration (ET) is perhaps the most difficult quantity to directly measure among the major water balance components. Because of the high cost and labor constraints associated with the direct measurement of ET, empirical data-driven modeling has frequently been used to estimate ET. Beyond the widely used traditional type regression that has the effect of producing ‘global’ parameter estimates, assumed to be uniform throughout an area, we utilized a more localized spatially non-stationary technique – the geographically weighted regression (GWR) – to estimate mean monthly ET in the Passaic River Basin (PRB). We identified the key environmental controls of ET and developed new sets of spatially varying empirical ET models based on variable combinations that produced the best-fit model. The analysis showed that temporal and spatial variabilities in ET over the PRB are driven by climatic and biophysical factors. We found that the key controlling factors were different from month to month, with wind speed being dominant throughout the year in the study basin. A monthly mean ET index map was further generated from the model to illustrate areas where ET exceeds precipitation. This will among others enable water loss due to evapotranspiration to be accounted for in future water supply plans for the basin.
A pragmatic approach to the combined effect of climate change and water abstraction on Lake Ziway water balance, Ethiopia
Authors: Ashagre Hailemariam Molla , Hatiye Samuel Dagalo , Goshime Demelash Wondimagegnehu 
Published: December 2022

AbstractClimate change and ongoing human activity have been threatening Ethiopia's Lake Ziway's water balance. However, few studies have been conducted to investigate the combined effects of climate change and water withdrawal on the lake's water balance using climate change and water withdrawal for irrigation. We used high-resolution multiple climate models and Representative Concentration Pathways (RCP) scenarios to assess the impact of climatic variables for two future periods: 2021–2050 and 2051–2080. Rainfall and temperature data biases were corrected using power transformation and variance scaling methods, respectively. The Hydrologiska Byråns Vattenbalansavdelning (HBV) hydrological model was employed to simulate surface inflow into Lake Ziway from the Meki and Katar sub-catchments. The FAO CROPWAT model was used to estimate the irrigation water demand of major crops grown in the study area. The results indicate that future temperatures and wet season runoff levels are expected to rise. Under the worst climate change scenario, climate change and water withdrawal from the lake for agriculture may cause the lake level to drop by 25 cm per year, resulting in a 10 km2 surface area and 101 Mm3 volume reductions. Therefore, implementing preventive measures, proper planning and careful monitoring of lake water use is advised.
High abundance of high-risk Human Papillomavirus genotypes in wastewater in Uruguay
Authors: Victoria Matías , Moller Ana , Salvo Matías , Baccardatz Natalia , Colina Rodney 
Published: December 2022

Abstract
The aim of this study was to determine the frequency of Human Papillomavirus (HPV) genotypes in wastewater of Salto city, Uruguay, in order to obtain a general overview of the circulating genotypes in their population. HPV was detected in 34% (32/93) of the wastewater samples collected and analyzed during 2020/21 in Salto city, Uruguay. Thirty-three genotypes were observed, of which 16 presented read abundance higher than 1%, including both high-risk (HR) and low-risk (LR) genotypes. HR genotypes 31, 16, 58, 52, 33 and 59 were detected representing 40% (163,220 reads) of the total read abundance, with genotypes 31 (64,365), 16 (39,337) and 58 (36,332) being the most abundant. LR genotypes 72, 6, 11 and 40 were also detected in a high frequency, accounting for 37% (148,359) of the HPV reads. This study highlights the high frequency of HR genotypes of HPV, circulating in the population of Salto city which is a burden in public health mainly due to the devastating impact of cervical cancer in women.
Nanoparticle and Stem Cell Combination Therapy for the Management of Stroke
Authors: Salatin Sara , Farhoudi Mehdi , Sadigh-Eteghad Saeed , Farjami Afsaneh 
Published: December 2022

Abstract:Stroke is currently one of the primary causes of morbidity and mortality worldwide. Unfortunately, the available treatments for stroke are still extremely limited. Indeed, stem cell (SC) therapy is a new option for the treatment of stroke that could significantly expand the therapeutic time window of stroke. Some proposed mechanisms for stroke-based SC therapy are the incorporation of SCs into the host brain to replace dead or damaged cells/tissues. Moreover, acute cell delivery can inhibit apoptosis and decrease lesion size, providing immunomudolatory and neuroprotection effects. However, several major SC problems related to SCs such as homing, viability, uncontrolled differentiation, and possible immune response, have limited SC therapy. A combination of SC therapy with nanoparticles (NPs) can be a solution to address these challenges. NPs have received considerable attention in regulating and controlling the behavior of SCs because of their unique physicochemical properties. By reviewing the pathophysiology of stroke and the therapeutic benefits of SCs and NPs, we hypothesize that combined therapy will offer a promising future in the field of stroke management. In this work, we discuss recent literature in SC research combined with NP-based strategies that may have a synergistic outcome after stroke incidence.
The Potential of Secondary Metabolites from Plants as Drugs or Leads
against Trypanosoma cruzi-An Update from 2012 to 2021
Authors: Lago Joao Henrique Ghilardi , Barbosa Henrique , Thevenard Fernanda , Quero Reimão Juliana , Tempone Andre Gustavo , Honorio Kathia Maria 
Published: December 2022

Background:
Chagas disease (American Trypanosomiasis) is classified by the World Health Organization (WHO) as one of the seventeen neglected tropical diseases (NTD), affecting, mainly, several regions of Latin America.

Introduction:
However, immigration has expanded the range of this disease to other continents. Thousands of patients with Chagas disease die annually, yet no new therapeutics for Chagas disease have been approved, with only nifurtimox and benznidazole available. Treatment with these drugs presents several challenges, including protozoan resistance, toxicity, and low efficacy. Natural products, including the secondary metabolites found in plants, offer a myriad of complex structures that can be sourced directly or optimized for drug discovery.

Method:
Therefore, this review aims to assess the literature from the last 10 years (2012-2021) and present the anti-T. cruzi compounds isolated from plants in this period, as well as briefly discuss computational approaches and challenges in natural product drug discovery. Using this approach, more than 350 different metabolites were divided based on their biosynthetic pathway alkaloids, terpenoids, flavonoids, polyketides, and phenylpropanoids which displayed activity against different forms of this parasite epimastigote, trypomastigote and more important, the intracellular form, amastigote.

Conclusion:
In this aspect, there are several compounds with high potential which could be consid-ered as a scaffold for the development of new drugs for the treatment of Chagas disease-for this, more advanced studies must be performed including pharmacokinetics (PK) and pharmacodynamics (PD) analysis as well as conduction of in vivo assays, these being important limitations in the dis-covery of new anti-T. cruzi compounds.
A Mini-review on the Application of Chemically Modified Sensing
Platforms for the Detection of Heavy Metal Ions in Water
Authors: Shaban Abdul , Szabó Tamás , Eddaif Larbi 
Published: December 2022

Abstract:
High levels of metallic ions, particularly heavy metals, can cause serious damage not only to
public health but to the whole ecosystem. Therefore, rapid and precise detection and monitoring of heavy
metals have become vital. The detection of heavy metals in water using conventional monitoring approaches
based on physicochemical and analytical procedures, e.g., inductively coupled plasma combined
with atomic absorption spectroscopy, X-ray fluorescence, instrumental neutron activation analysis, etc.,
has been immensely utilized. However, the sophisticated sample preparation and evaluation procedures
for most of the mentioned methods are time- and labor-intensive, and economically more favorable detection
approaches, e.g., sensors and lab-on-a-chip techniques, are being developed. Chemical sensors (electrochemical,
optical, and piezogravimetric) with different sensing platforms (nanostructures, biological,
polymeric, and macrocyclic) have been considered to be the most promising ones, owing to their strong
adsorption of target elements, fast electron transfer kinetics, and biocompatibility, which are very apt for
sensing applications. The combination of electrochemical, optical, and piezogravimetric techniques with
nanomaterials has enhanced the sensitivity, limit of detection, and robustness of the chemosensors. Following
this perspective, this review highlights surface modification platforms of sensors that enhance the
detection properties (sensitivity, selectivity, limit of detection, and linear range) of the proposed devices,
including nanostructures, biological networks, polymers, and macrocycles with a special emphasis on
calixarenes/resorcinarenes oligomers. The capabilities, limitations, and prospect assessments of the covered
techniques in detection and monitoring have been highlighted.
The Anti-Viral Activity of Stem Cells: A Rational Explanation for their Use
in Clinical Application
Authors: Balzanelli Mario Giosuè , Distratis Pietro , Lazzaro Rita , Pham Van Hung , Tran Toai Cong , Dipalma Gianna , Inchingolo Francesco , Serlenga Emilio Maria , Aityan Sergey Khachatur , Ballini Andrea , Nguyen Kieu Cao Diem , Isacco Ciro Gargiulo 
Published: December 2022

Abstract:
It is well established the importance of stem cells (SCs) in tissue growth, regeneration
and repair, given their ability to self-renew and differentiate into mature cells. Stem cells are present
in all individuals and are potentially active to the end of life. However, less is known about their
unique function within the immune system as immune regulators and their important task in viral
protection. Antiviral resistance is a common mechanism in all cells though stem cells utilize an
antiviral RNA interference (RNAi) mechanism, while adult cells react by using the interferondependent
repression pathway via interferon-associated protein-based response to induce an
antiviral response. Therefore, the idea behind this review is to highlight the mechanisms of viral
evasion of host defense, which would then allow us to highlight the rationale use of autologous stem
cells and their biochemical and immunological ability to reset the subverted immune responses.
Recently, scientists have highlighted their use in the field of immune-therapy, establishing the
possibilities of using them outside the conventional protocol with the advancement in manipulating
these cells in such a way that specific body activity can be restored. This paper describes the
remarkable SCs profile and discusses some ideas regarding their promising use in vivo.