bluuebunny/crossref_metadata_2025_split huggingface dataset:
To Triumph or to Socialize? The Role of Gaming Motivations in Multiplayer Online Battle Arena Gameplay Preferences
Authors: Bonny Justin W. , Castaneda Lisa M. 
Published: February 2022

Background Individuals choose to engage in multiple types of online team-based video games. Gameplay options allow for player preferences to shape their gaming experience. Within the multiplayer online battle arena (MOBA) genre, players can decide whether to play matches with familiar or random teammates and whether their performance impacts their skill rating. Individual differences in video game engagement and genre preferences have been connected with player motivations and uses of video games and psychological traits that influence social interactions. The present study examined the extent to which the match preferences of MOBA players related to these factors. Methods Individuals attending an international MOBA tournament were recruited for the present research. Player MOBA match selection history was collected along with questionnaires measuring video game uses and gratifications, preference for solitude, tolerance of disagreement, and a test of theory of mind ability. Results Three main findings were observed. First, the highest-rated video game motivation was to socially interact with others. Second, players that displayed different preferences for types of MOBA matches varied in social interaction and competition video gameplay motivation scales. Third, although individual differences in fantasy video game motivation were correlated with theory of mind ability and preference for solitude, they did not vary by MOBA match preferences. Conclusion The results of the present study indicated that MOBA players were more strongly motivated by social aspects of video gameplay and variations in video game motivation to compete correlated with the extent to which they engaged in different types of MOBA play.
Risk factors of esophageal fistula induced by re-radiotherapy for recurrent esophageal cancer with local primary site
Authors: Wang Xinran , Hu Bing , Chen Jinhu , Xie Feihong , Han Dan , Zhao Qian , Sun Hongfu , Fu Chengrui , Liu Chengxin , Wang Zhongtang , Lin Haiqun , Huang Wei 
Published: February 2022

Abstract
Purpose
The purpose of the present study was to investigate risk factors for esophageal fistula (EF) in patients with recurrent esophageal cancer receiving re-radiotherapy with or without chemotherapy.

Methods
We reviewed retrospectively the clinical characters and dosimetric parameters of 96 patients with recurrent esophageal cancer treated with re-radiotherapy in Cancer Hospital Affiliated to Shandong First Medical University between August 2014 and January 2021.Univariate and multivariate logistic regression analyses were provided to determine the risk factors of EF induced by re-radiotherapy.

Results
The median time interval between two radiotherapy was 23.35 months (range, 4.30 to 238.10 months). EF occurred in 19 patients (19.79%). In univariate analysis, age, T stage, the biologically equivalent dose in the re-radiotherapy, total biologically equivalent dose, hyperfractionated radiotherapy, ulcerative esophageal cancer, the length of tumor and the maximum thickness of tumor had a correlation with the prevalence of EF. In addition, age (HR = 0.170, 95%CI 0.030–0.951, p = 0.044), T stage (HR = 8.369, 95%CI 1.729–40.522, p = 0.008), ulcerative esophageal cancer (HR = 5.810, 95%CI 1.316–25.650, p = 0.020) and the maximum thickness of tumor (HR = 1.314, 95%CI 1.098–1.572, p = 0.003) were risk factors of EF in multivariate logistic regression analysis.

Conclusions
The incidence of EF was significantly increased in patients with recurrent esophageal cancer who underwent re-radiotherapy. This study revealed that age, T stage, ulcerative esophageal cancer and the maximum thickness of the tumor were risk factors associated with EF. In clinical work, patients with risk factors for EF ought to be highly concerned and individualized treatment plans should be taken to reduce the occurrence of EF.
Women’s perceptions of PERSPECTIVE: a breast cancer risk stratification e-platform
Authors: Ahmed Saima , Lévesque Emmanuelle , Garland Rosalind , Knoppers Bartha , Dorval Michel , Simard Jacques , Loiselle Carmen G. 
Published: February 2022

Abstract
Background
Breast cancer risk stratification categorizes a woman’s potential risk of developing the disease as near-population, intermediate, or high. In accordance, screening and follow up for breast cancer can readily be tailored following risk assessment. Recent efforts have focussed on developing more accessible means to convey this information to women. This study sought to document the relevance of an informational e-platform developed for these purposes.

Objective
To begin to assess a newly developed breast cancer risk stratification and decision support e-platform called PERSPECTIVE (PErsonalised Risk Stratification for Prevention and Early deteCTIon of breast cancer) among women who do not know their personal breast cancer risk (Phase 1). Changes (pre- and post- e-platform exposure) in knowledge of breast cancer risk and interest in undergoing genetic testing were assessed in addition to perceptions of platform usability and acceptability.

Methods
Using a pre-post design, women (N = 156) of differing literacy and education levels, aged 30 to 60, with no previous breast cancer diagnosis were recruited from the general population and completed self-report e-questionnaires.

Results
Mean e-platform viewing time was 18.67 min (SD 0.65) with the most frequently visited pages being breast cancer-related risk factors and risk assessment. Post-exposure, participants reported significantly higher breast cancer-related knowledge (p < .001). Increases in knowledge relating to obesity, alcohol, breast density, menstruation, and the risk estimation process remained even when sociodemographic variables age and education were controlled. There were no significant changes in genetic testing interest post-exposure. Mean ratings for e-platform acceptability and usability were high: 26.19 out of 30 (SD 0.157) and 42.85 out of 50 (SD 0.267), respectively.

Conclusions
An informative breast cancer risk stratification e-platform targeting healthy women in the general population can significantly increase knowledge as well as support decisions around breast cancer risk and assessment. Currently underway, Phase 2, called PERSPECTIVE, is seeking further content integration and broader implementation .
Increased biting rate and decreased Wolbachia density in irradiated Aedes mosquitoes
Authors: Moretti Riccardo , Lampazzi Elena , Damiani Claudia , Fabbri Giulia , Lombardi Giulia , Pioli Claudio , Desiderio Angiola , Serrao Aurelio , Calvitti Maurizio 
Published: February 2022

AbstractBackgroundReleasing considerable numbers of radiation-sterilized males is a promising strategy to suppress mosquito vectors. However, releases may also include small percentages of biting females, which translate to non-negligible numbers when releases are large. Currently, the effects of irradiation on host-seeking and host-biting behaviors have not been exhaustively investigated. Information is also lacking regarding the effects of sterilizing treatment on the endosymbiotic bacteriumWolbachia, which is known to affect the vector competence of infected mosquitos.MethodsTo ascertain the effects of irradiation on females, the pupae of twoAedes albopictusstrains, differing in their natural or artificialWolbachiainfection type, andAedes aegypti—which is not infected byWolbachia—were treated with various doses of X-rays and monitored for key fitness parameters and biting behavior over a period of 2 weeks. The effect of radiation onWolbachiawas investigated by quantitative polymerase chain reaction (qPCR) and fluorescence in situ hybridization (FISH) analysis.ResultsPartialAedes albopictusfemale sterility was achieved at 28 Gy, but the number of weekly bites more than doubled compared to that of the controls. Radiation doses of 35 and 45 Gy completely inhibited progeny production but did not significantly affect the survival or flight ability ofAe. albopictusfemales and caused a tripling of the number of bites per female per week (compared to untreated controls). These results were also confirmed inAe. aegyptiafter treatment at 50 Gy.Wolbachiadensity decreased significantly in 45-Gy-irradiated females, with the greatest decreases in the early irradiation group (26 ± 2-h-old pupae).Wolbachiadensity also decreased as adults aged. This trend was confirmed in ovaries but not in extra-ovarian tissues. FISH analysis showed a strongly reducedWolbachia-specific fluorescence in the ovaries of 13 ± 1-day-old females.ConclusionsThese results suggest that, under sterile insect technique (SIT) programs, the vector capacity of a target population could increase with the frequency of the irradiated females co-released with the sterile males due to an increased biting rate. In the context of successful suppression, the related safety issues are expected to be generally negligible, but they should be conservatively evaluated when large-scale programs relying on imperfect sexing and high overflooding release ratios are run for long periods in areas endemic for arboviral diseases. Also, the effects of irradiation on the vector competence deserve further investigation.Graphical Abstract
A mutation-based gene set predicts survival benefit after immunotherapy across multiple cancers and reveals the immune response landscape
Authors: Long Junyu , Wang Dongxu , Wang Anqiang , Chen Peipei , Lin Yu , Bian Jin , Yang Xu , Zheng Mingjun , Zhang Haohai , Zheng Yongchang , Sang Xinting , Zhao Haitao 
Published: February 2022

Abstract
Background
Immune checkpoint inhibitor (ICI) therapy has revolutionized the treatment of many cancers. However, the limited population that benefits from ICI therapy makes it necessary to screen predictive biomarkers for stratifying patients. Currently, many biomarkers, such as tumor mutational burden (TMB), have been used in the clinic as indicative biomarkers. However, some high-TMB patients with mutations in genes that are closely related to immunotherapeutic resistance are not sensitive to ICI therapy. Thus, there is a need to move beyond TMB and identify specific genetic determinants of the response to ICI therapy. In this study, we established a comprehensive mutation-based gene set across different tumor types to predict the efficacy of ICI therapy.

Methods
We constructed and validated a mutational signature to predict the prognosis of patients treated with ICI therapy. Then, the underlying immune response landscapes of different subtypes were investigated with multidimensional data.

Results
This study included genomic and clinical data for 12,647 patients. An eleven-gene mutation-based gene set was generated to divide patients into a high-risk group and a low-risk group in a training cohort (1572 patients with 9 types of cancers who were treated with ICI therapy). Validation was performed in a validation cohort (932 patients with 5 types of cancers who were treated with ICI therapy). Mutations in these 11 genes were associated with a better response to ICI therapy. In addition, the mutation-based gene set was demonstrated to be an independent prognostic factor after ICI therapy. We further explored the role of the immune context in determining the benefits of immunotherapy in 10,143 patients with 33 types of cancers and found distinct immune landscapes for the high- and low-risk groups.

Conclusions
The mutation-based gene set developed in this study can be used to reliably predict survival benefit across cancers in patients receiving ICI therapy. The close interplay between the extrinsic and intrinsic immune landscapes in the identified patient subgroups and the subgroups’ differing responses to ICI therapy could guide immunotherapy treatment decisions for cancer patients.
Excess use of thyroid hormone treatment among patients with fibromyalgia: a cross-sectional study in primary health care
Authors: Aleksi Varinen , Elise Kosunen , Koskela Tuomas H. 
Published: February 2022

Abstract
Objective
From previous studies, it is known that the association between fibromyalgia and thyroid autoimmunity diseases exists. On the other hand, it was recently suggested that in many cases thyroid hormone treatment might be unnecessary. The aim of our study is to explore the thyroid hormone treatment among primary health care fibromyalgia patients. Our study is cross-sectional and based on fibromyalgia study from the city of Nokia Health Center. Clinical examination was performed to participants, patients filled five questionnaires and information from electronic patient records was gathered. In addition to other parameters, we studied patient’s thyroid function levels at the beginning of thyroid hormone treatment.

Results
From those patients participating in the study (n = 103), 34% (n = 33) had thyroid hormone treatment. From those taking thyroid hormone treatment, 48% (n = 16) had information regarding the initial TSH and T4-V levels at the beginning of the treatment. 37% (n = 6) of them had normal thyroid function. Small sample size and data gathered from single health center effects on the generalizability of our findings. However, we suggest further studies to confirm the potential association between fibromyalgia and inappropriate thyroid hormone treatment.
Evaluation of the dependence of radiomic features on the machine learning model
Authors: Demircioğlu Aydin 
Published: February 2022

Abstract
Background
In radiomic studies, several models are often trained with different combinations of feature selection methods and classifiers. The features of the best model are usually considered relevant to the problem, and they represent potential biomarkers. Features selected from statistically similarly performing models are generally not studied. To understand the degree to which the selected features of these statistically similar models differ, 14 publicly available datasets, 8 feature selection methods, and 8 classifiers were used in this retrospective study. For each combination of feature selection and classifier, a model was trained, and its performance was measured with AUC-ROC. The best-performing model was compared to other models using a DeLong test. Models that were statistically similar were compared in terms of their selected features.

Results
Approximately 57% of all models analyzed were statistically similar to the best-performing model. Feature selection methods were, in general, relatively unstable (0.58; range 0.35–0.84). The features selected by different models varied largely (0.19; range 0.02–0.42), although the selected features themselves were highly correlated (0.71; range 0.4–0.92).

Conclusions
Feature relevance in radiomics strongly depends on the model used, and statistically similar models will generally identify different features as relevant. Considering features selected by a single model is misleading, and it is often not possible to directly determine whether such features are candidate biomarkers.
Nurses’ knowledge, attitudes, and willingness to practice hospice care: An analysis of influencing factors
Authors: Chen Lin , Li Xiao-Hong , Pan Xiao , Pan Qi-Ni , Huang Hui-Qiao , Tao Pin-Yue , Li Gao-Ye , Ma Jin-Hui , Huang Jing-Can 
Published: February 2022

Background
Hospice care is a multidisciplinary approach that focused on patients’ quality of life, and nurses allocate more of their time with patients and patients’ families than those nurses working in other disciplines. Nurses’ knowledge of and attitudes toward hospice care can affect the quality of hospice care. At present, China’s hospice care institutions are suffering from an obvious shortage of nursing staff. Since clinical nurses are the main force behind the future provision of hospice care, their knowledge of, attitudes and willingness to practice can greatly promoted the growth of hospice care, however, available data on clinical nurses’ willingness to practice hospice care are limited.

Methods
A cross-sectional descriptive study design was employed to collect data from 1833 nurses working in tertiary or secondary general hospitals in Guangxi, China. We examined nurses’ demographic characteristics and scores on the Chinese version of the hospice care knowledge scale, the Chinese version of the Bradley Attitude Assessment Questionnaire, and a brief quiz concerning their willingness to practice hospice care in the future. Descriptive, single factor, multiple regression analyses and logistic regression analyses were used for data analysis.

Results
Nurses displayed moderate mean scores for both knowledge of and attitudes, and only 505 (27.5%) nurses expressed their willingness to practice hospice care, 1329 (72.5%) of nurses sampled expressed their unwillingness or uncertainty. Multivariate regression analyses showed that education, professional qualification, monthly income, whether they had been trained in hospice care, and willingness to practice hospice care were the main influencing factors of knowledge; education, whether they lived with someone aged >60 years, and whether they had been trained in hospice care were main factors influencing attitudes. Additionally, logistic regression analyses showed that hospice care knowledge, whether they had been trained in hospice care, and whether they had clinical experience affected the nurses’ willingness to practice hospice care.

Conclusion
This study highlighted a knowledge gap and moderate attitudes toward hospice care among nurses, and most nurses did not prefer to practice hospice care. Having been trained in hospice care was the main common factor of nurses’ knowledge of, attitudes toward, and willingness to practice hospice care in the future, indicating the necessity to provide nurses with more targeted hospice care training.
Black and White Bioscope: Making Movies in Africa 1899 to 1925, Neil Parsons (2018)
Authors: Jansen van Vuuren Anna-Marie 
Published: February 2022

Review of: Black and White Bioscope: Making Movies in Africa 1899 to 1925, Neil Parsons (2018)
Bristol and Pretoria: Intellect and Protea Publishers, xii + 252 pp.,
ISBN 978-1-78320-943-9 (Intellect)/ISBN 978-1-48530-955-0 (Protea), h/bk, GBP 55/R 325
Moroccan Cinema Uncut: Decentred Voices, Transnational Perspectives, Will Higbee, Florence Martin and Jamal Bahmad (2020)
Authors: Chemlal Said 
Published: February 2022

Review of: Moroccan Cinema Uncut: Decentred Voices, Transnational Perspectives, Will Higbee, Florence Martin and Jamal Bahmad (2020)
Edinburgh: Edinburgh University Press, 277 pp.,
ISBN 978-1-47447-793-2, h/bk, USD 80
PLATFORM EMPLOYMENT IS THE MAIN TREND OF LABOR MARKET DEVELOPMENT IN MODERN CONDITIONS
Authors: Glotova N. I. , Gerauf Yu. V. 
Published: February 2022

The relevance of the study lies in the fact that today the infrastructural development of the labor market is associated primarily with digital platforms, which are the main tool for balancing supply and demand in terms of employer and jobseeker activity. The emergence of digital platforms has changed the organization and structure of the labor market. The coronavirus pandemic has further contributed to the development of employment on service-oriented and web-based platforms. Russian business, in order to reduce its costs, began to willingly use the services of freelancers. However, the regime of the self-employed, today, does not imply social guarantees, the consolidation of which in Russian legislation will contribute not only to an increase in the number of «legal» selfemployed, but also to the country’s economy as a whole.
The article reveals the role of platform employment as the main tool for compensating for structural problems or shifts when capable, but not employed people appear in society. The main advantages and disadvantages of digital platforms for workers, employers and the economy as a whole are characterized. The aim of this work is to study platform employment as the main trend in the development of the labor market in Russia, to identify the advantages and risks of platform employment, as well as tools for its regulation.
TRANSFORMATION OF THE FORMAT OF LABOR PROTECTION REQUIREMENTS IN CONNECTION WITH CONSUMER HABITS OF INFORMATION PERCEPTION
Authors: Senchenko V. A. , Kaverzneva T. T. , Kitaev S. V. , Abdrakhmanov N. Kh. 
Published: February 2022

Instructions on labor protection in today’s form have existed since the last century. During this time, mobile phones and the Internet appeared, people landed on the moon. The occupational safety instructions remained unchanged.
Generation Z is increasingly beginning to enter the workforce. It’s representatives are distinguished from the previous generation by the fact that they were actually “born with tablets, mobile phones and smartphones.” From birth, they are surrounded by a “digital web”, since Internet technologies are an integral part of their parents’ lives. This is the first generation deeply involved in digital technologies, so the archaic format of reporting labor protection requirements in form and content for new generations becomes ineffective.
This article provides a historical digression of the legislative framework regulating the legal status of labor protection instructions. The calculation of the economic officiency of paper and digital virsions of their placement has been carried out. The transition to the digital format of labor protection instructions based on changes in consumer habits of information perception is justified. For the convenience of using the instructions, it is proposed to use a QR-code with a link to the location of the place of their placement.
Caracterización de quiste tirogloso en pacientes pediátricos
Authors: Cuastumal Maria Eugenia , Mejía Zapata Liliana María 
Published: February 2022

Introducción: el quiste del conducto tirogloso es una anomalía congénita frecuente en la línea media del cuello, generalmente se manifiesta durante la primera década de la vida, pero puede manifestarse a cualquier edad. Clásicamente se presenta como una masa en la línea media anterior que se mueve con la deglución y la protrusión de la lengua; en ocasiones se presenta de manera atípica lo que puede dificultar el diagnostico. Tiene una tasa de recurrencia del 4% al 50 % aun después de la cirugía electiva de Sistrunk. Objetivo: caracterizar la forma de presentación clínica y el tratamiento de los pacientes pediátricos con diagnostico de quiste tirogloso en una institución pediátrica. Métodos: estudio descriptivo retrospectivo durante el periodo del 2010 - 2020 Resultados: se identificaron 59 pacientes con quiste tirogloso, de los cuales el promedio de edad fue de 5.8 años, el 50.9 % eran del sexo masculino, la localización más frecuente hallada fue en la región medial del cuello 86.4 %, los pacientes principalmente presentaron sensación de masa indolora en esta región en el 74.5 %, secreción 18.6 %, sensibilidad y enrojecimiento 5.1 %, disfagia 1.7 %. La expresión clínica más frecuente de la masa en cuello fue la presencia de quiste tirogloso en el 74.8 % de los casos y el debut con fistula en el 11.6 %. Conclusión: la ecografía de cuello evidencio en un 100 % de los casos el quiste tirogloso y logro ubicar la presencia de glándula tiroides en su sitio habitual en el 88 %, al 20.3 % de los pacientes se les tomo pruebas tiroideas y gammagrafía al 12 % de ellos; se detectó recurrencia en 9 pacientes.