bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opioid-Induced Pronociceptive Signaling in the Gastrointestinal Tract Is Mediated by Delta-Opioid Receptor Signaling
Authors: Jaramillo-Polanco Josue , Lopez-Lopez Cintya , Yu Yang , Neary Emma , Hegron Alan , Canals Meritxell , Bunnett Nigel W. , Reed David E. , Lomax Alan E. , Vanner Stephen J. 
Published: March 2022

Opioid tolerance (OT) leads to dose escalation and serious side effects, including opioid-induced hyperalgesia (OIH). We sought to better understand the mechanisms underlying this event in the gastrointestinal tract. Chronicin vivoadministration of morphine by intraperitoneal injection in male C57BL/6 mice evoked tolerance and evidence of OIH in an assay of colonic afferent nerve mechanosensitivity; this was inhibited by the δ-opioid receptor (DOPr) antagonist naltrindole when intraperitoneally injected in previous morphine administration. Patch-clamp studies of DRG neurons following overnight incubation with high concentrations of morphine, the µ-opioid receptors (MOPr) agonist [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin (DAMGO) or the DOPr agonist [D-Ala2, D-Leu5]-Enkephalin evoked hyperexcitability. The pronociceptive actions of these opioids were blocked by the DOPr antagonist SDM25N but not the MOPr antagonist D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2. The hyperexcitability induced by DAMGO was reversed after a 1 h washout, but reapplication of low concentrations of DAMGO or [D-Ala2, D-Leu5]-Enkephalin restored the hyperexcitability, an effect mediated by protein kinase C. DOPr-dependent DRG neuron hyperexcitability was blocked by the endocytosis inhibitor Pitstop 2, and the weakly internalizing DOPr agonist ARM390 did not cause hyperexcitability. Bioluminescence resonance energy transfer studies in HEK cells showed no evidence of switching of G-protein signaling from Gito a Gspathway in response to either high concentrations or overnight incubation of opioids. Thus, chronic high-dose opioid exposure leads to opioid tolerance and features of OIH in the colon. This action is mediated by DOPr signaling and is dependent on receptor endocytosis and downstream protein kinase C signaling.SIGNIFICANCE STATEMENTOpioids are effective in the treatment of abdominal pain, but escalating doses can lead to opioid tolerance and potentially opioid-induced hyperalgesia. We found that δ-opioid receptor (DOPr) plays a central role in the development of opioid tolerance and opioid-induced hyperalgesia in colonic afferent nociceptors following prolonged exposure to high concentrations of MOPr or DOPr agonists. Furthermore, the role of DOPr was dependent on OPr internalization and activation of a protein kinase C signaling pathway. Thus, targeting DOPr or key components of the downstream signaling pathway could mitigate adverse side effects by opioids.
Primary hyperaldosteronism induces congruent alterations of sodium homeostasis in different skeletal muscles: a 23Na-MRI study
Authors: Christa Martin , Hahner Stefanie , Köstler Herbert , Bauer Wolfgang Rudolf , Störk Stefan , Weng Andreas Max 
Published: March 2022

Background
Sodium homeostasis is disrupted in many cardiovascular diseases, which makes non-invasive sodium storage assessment desirable. In this regard, sodium MRI has shown its potential to reveal differences in sodium content between healthy and diseased tissues as well as treatment-related changes of sodium content. When different tissues are affected disparately, simultaneous assessment of these compartments is expected to provide better information about sodium distribution, reduce examination time, and improve clinical efficiency.

Objectives
The objectives were (1) to investigate sodium storage levels in calf and pectoral muscle in healthy controls and patients and quantify changes following medical treatment and (2) to demonstrate homogeneous disruption in skeletal muscle sodium storage in patients with primary hyperaldosteronism (PHA).

Methods
We assessed sodium storage levels (relative sodium signal intensity, rSSI) in the calf and pectoral muscles of eight patients with PHA prior and after treatment and 12 age- and sex-matched healthy volunteers.

Results
Calf and pectoral muscle compartments exhibited similar sodium content both in healthy subjects (calf vs pectoral rSSI: 0.14 ± 0.01 vs 0.14 ± 0.03) and PHA patients (calf vs pectoral rSSI: 0.19 ± 0.03 vs 0.18 ± 0.03). Further, we observed similar treatment-related changes in pectoral and calf muscles in the patients (proportional rSSI change calf: 26%; pectoral: 28%).

Conclusion
We found that sodium was distributed uniformly and behaved equally in different skeletal muscles in Conn’s syndrome. This allows to measure both heart and skeletal muscle sodium signals simultaneously by a single measurement without repositioning the patient. This increases 23Na-MRI’s clinical feasibility as an innovative technique to monitor sodium storage.
La inserción del fonema /rˇ/ en el quechua actual: una explicación desde una teoría de las clases naturales
Authors: Meneses Tutaya Norma 
Published: March 2022

En el presente estudio se plantea una explicación probable de la inserción de la vibrante múltiple prepalatal
/ř/ como un segmento «natural» en el inventario fonológico del quechua actual pese a la evidencia de que se deriva del contacto con el español. Es decir, que el fonema /ř/ ha sido incorporado al sistema fonológico de algunos dialectos quechuas y está en proceso de estarlo en otros, debido fundamentalmente a que corresponde a una posición «naturalmente aceptable» dentro del sistema del quechua más que a un préstamo o a una interferencia del español andino. En todo caso, sin dejar de lado ambas explicaciones, planteo que el factor determinante es intrínseco al sistema fonológico del quechua y que esto se explica desde un enfoque que denomino teoría de las clases naturales. Por este concepto, el sistema consonántico del quechua está organizado en subsistemas de clases naturales donde prevalece la clase [+cons, +cor] en cuyo interior se produce la oposición entre las subclases [+cons, +cor, +ant] / [+cons, +cor, +post]. La presencia de la vibrante múltiple retrofleja se explicaría por su reubicación en la segunda subclase donde rellena una casilla vacía.
Los valores de la cultura andina y una reflexión sobre la necesidad de su cultivo formal a través de la EIB
Authors: Meneses Tutaya Norma 
Published: March 2022

Basándonos en un análisis semántico-discursivo de las entrevistas realizadas a un conjunto variado de personas, que se autoidentifican de la cultura andina, sobre cuáles son los valores más importantes que sirven para determinar la integridad de una persona, se puede concluir que los cinco valores fundamentales de la cultura andina en orden de jerarquía son: laboriosidad, humildad, responsabilidad, reciprocidad y solidaridad. Cabe anotar que no se trata de valores privativos de esta cultura.
La reflexión final es que toda educación formal debe estar orientada al cultivo de los valores y los principios cognoscitivos de la cultura propia de cada pueblo que se materializan en todo su acervo, es decir, a coadyuvar el cumplimiento del proceso de enculturación y socialización de las nuevas generaciones. Puesto que la actual sociedad peruana es pluricultural y multilingüe _ya que contiene pueblos con distintos esquemas gnoseológico-axiológicos que hasta la actualidad conviven en una relación conflictiva de dominación-resistencia_ es necesario que todo el sistema de la educación formal del país sea intercultural y bilingüe.
Estudio de los sufijos del Manuscrito Quechua de Huarochirí (s. XVI) Study of the suffixes in the Huarochiri Manuscript (16th century)
Authors: Baldoceda Espinoza Ana , Huanca Quispe Jaime , Chalco Arangoitia Walter , Solís Aroni Nora 
Published: March 2022

Gerald Taylor, el renombrado especialista en el Manuscrito Quechua de Huarochirí (MQH), tradujo el texto quechua empleando una escritura fonológica, pero un análisis gramatical o la descripción de sufijos excedía el propósito de su trabajo, por lo cual nos impusimos la tarea de analizar los sufijos.
Este artículo se basa en la investigación realizada en el Proyecto «Estudio de los sufijos del Manuscrito Quechua de Huarochirí (s. XVI)» en el cual hemos analizado los sufijos utilizados en el Manuscrito Quechua de Huarochirí (MQH), tanto los de los paradigmas nominal y verbal como los enclíticos. En el paradigma nominal, se ha descrito las características de los sufijos formativos, lo cual ayuda a conocer la verdadera raíz de palabras que terminan en -n y en -y, como hatun, wakin, uray; en el paradigma verbal se ha registrado la presencia de sufijos como -mpu y -tamu, que ya no se usan en las variedades modernas de quechua; también se ha establecido que en presencia de los sufijos -mu y -pu no se produce el cambio común de /u/ en /a/; así, tenemos en el MQH ruraykupuy, no ruraykapuy.
Ground-Motion Modeling as an Image Processing Task: Introducing a Neural Network Based, Fully Data-Driven, and Nonergodic Approach
Authors: Lilienkamp Henning , von Specht Sebastian , Weatherill Graeme , Caire Giuseppe , Cotton Fabrice 
Published: March 2022

ABSTRACT
We construct and examine the prototype of a deep learning-based ground-motion model (GMM) that is both fully data driven and nonergodic. We formulate ground-motion modeling as an image processing task, in which a specific type of neural network, the U-Net, relates continuous, horizontal maps of earthquake predictive parameters to sparse observations of a ground-motion intensity measure (IM). The processing of map-shaped data allows the natural incorporation of absolute earthquake source and observation site coordinates, and is, therefore, well suited to include site-, source-, and path-specific amplification effects in a nonergodic GMM. Data-driven interpolation of the IM between observation points is an inherent feature of the U-Net and requires no a priori assumptions. We evaluate our model using both a synthetic dataset and a subset of observations from the KiK-net strong motion network in the Kanto basin in Japan. We find that the U-Net model is capable of learning the magnitude–distance scaling, as well as site-, source-, and path-specific amplification effects from a strong motion dataset. The interpolation scheme is evaluated using a fivefold cross validation and is found to provide on average unbiased predictions. The magnitude–distance scaling as well as the site amplification of response spectral acceleration at a period of 1 s obtained for the Kanto basin are comparable to previous regional studies.
Psychological and pedagogical conditions for professional motivation of pedagogical specialties students
Authors: Perizat Dautkalieva , Zaure Ormanova , Zhanna Axakalova , Madina Baibekova , Tolkyn Ingaybekova 
Published: March 2022

In our rapidly developing modern world, where there are trends of high growth in science and technology, there is an acute need for professionally motivated and highly qualified specialists. This article discusses the features of professional motivation of students of pedagogical specialties. To determine the specifics of the formation of professional motivation of future teachers, an experimental study was conducted. The research consisted of 256 third-year students in natural sciences at the Abai Kazakh Pedagogical University in Kazakhstan. In forming the structure of professional motivation of students of pedagogical specialties in our research, we relied on the motivation structure developed by Ilyin. The data obtained made it possible to determine the features of the formation of professional motivation of students of pedagogical specialties, depending on the features of vocational training.

Keywords: competence-based approach; professional motivation; paradigm of education; project-based activity.
The attitude of teachers toward students’ self-assessment of educational achievements in inclusive education lessons
Authors: Kalykbayeva Almagul , Autayeva Akbota , Orazayeva Gulzhan , Kassymzhanova Gulnar , Zhigitbekova Bakyt , Bekmuratova Gulzhanar 
Published: March 2022

Self-assessment is to engage students as active participants in their learning and to reflect the results of their efforts since the key idea of self-assessment is that a child should achieve the learning goal and realize his achievements. The purpose of the study is to reveal the factors causing the lack of self-assessment in primary school lessons. The research collected data using observations and a questionnaire. The participants included 60 primary school teachers from the school of Almaty, the Republic of Kazakhstan. The collected data were analyzed using percentages. Based on the results of the research, the lack of the self-assessment component in the educational process is caused by the lack of assessment tools, which explains the negative attitude of teachers toward self-assessment. The efficiency of the implementation of the innovation in inclusive education needs to ensure the proper training of teachers, including key competencies for working in inclusive classes, and strengthening of its practical component.
Keywords: self-assessment, educational process, assessment, students with SEN
Escape Room Educativo como estrategia para innovar en enseñanza de segundas lenguas
Authors: De Ros Cócera Lucía , Polyakova Nesterenko Oksana 
Published: March 2022

Resumen:
En este trabajo mostramos y analizamos una metodología innovadora y motivadora aplicada en el proceso de enseñanza-aprendizaje de segundas lenguas, Escape Room Educativo. Llevamos a cabo una muestra de profesores que realizaron esta experiencia para posteriormente darnos su visión en la posible aplicación de esta metodología en las aulas de segundas lenguas. Así, presentando resultados de la prueba piloto y relacionándolos con la valoración de los sujetos participantes podremos evidenciar los beneficios que nos aporta esta herramienta metodológica para el aula y los avances que nos puede proporcionar en el proceso de enseñanza-aprendizaje.
Palabras clave: innovación, segundas lenguas, Aprendizaje Basado en Juegos (ABJ), Escape Room Educativo
Adaptive Rank-Based Selection of Geological Realizations for Optimum Field Development Planning
Authors: Arouri Yazan , Sayyafzadeh Mohammad , Begg Steve 
Published: March 2022

SummaryUncertainties are present in many decision-making processes. In field development planning, these uncertainties, typically represented by a set of geological realizations, need to be propagated in response to any proposed alternative (solution). Incorporation of the full set of realizations results in the oil and gas field development optimization problem—where either an algorithm iteratively tries to find the best solution from all the possible alternatives or the best solution must be selected from a set of predefined engineering judgment-driven development scenarios (i.e., set of either well control or well placement settings)—becoming computationally demanding. As such, realization subset selection techniques are required to reduce the computational overhead. We first introduce a reformulation of the subset selection problem to one that aims at ensuring consistent ranking of alternatives between those obtained by the full set and the selected subset. We argue that this should be the ultimate goal of any subset selection technique in such problems. In addition, we also propose a technique which selects a subset that minimizes the difference between the rankings obtained by the full set and subset, for a small batch of alternatives. The key idea, which we investigate thoroughly, is that there is a positive association between the goodness (in terms of ranking alternatives) of the subset selected using a small batch of alternatives and its fidelity in ranking other alternatives. Unlike previous methods, this technique does not depend on selecting subjective (static) properties to perform the subset selection nor does it rely only on flow-response vectors of a base-case scenario. In this work, the proposed technique is assessed using well placement and well control development alternatives to determine the applicability within field development planning. Additionally, the proposed subset selection technique is implemented in an adaptive scheme to solve a well placement optimization problem. The results are promising as the proposed technique consistently selects subsets that are able to rank development alternatives in a similar manner to the full set regardless of the type of development strategy (well control settings or well placement). Furthermore, the implementation of the proposed technique in an adaptive scheme is able to reduce the computational costs, on average, by a factor close to 9 without compromising the solution found for well placement optimization.
Effects of Exercise on Inflammatory Factors and IGF System in Breast Cancer Survivors: A Meta-analysis
Authors: Zhou Yanan , Jia Ningxin , Ding Meng 
Published: March 2022

Abstract
Background: To analyze the effects of exercise on IGF system and inflammatory factors in breast cancer survivors, and to provide evidence for the relationship between exercise and the hypothetical mechanism of preventing the development of breast cancer and improving its prognosis.Methods: Pubmed, Embase, Web of science, CNKI , Wanfang and VIP (China Science and Technology Journal) were systematically searched until April 2021. Search terms included “exercise”, "inflammatory factors", "IGF system" and "breast cancer". A total of 1066 related articles were searched. All the statistical results were analyzed by STATA 14.0 and Rstudio 4.1.1.Results: We found that exercise significantly reduced the level of IGF-1 (WMD, -19.947ng/ml; 95%CI, -22.669 to -17.225; P=0.000). Subgroup analysis showed that in the studies with intervention period> 12 weeks, exercise could significantly reduce the level of IL-6 (WMD,-0.761 pg/ml; 95%CI,-1.369 to -0.153 ; p= 0.014), while in the studies with intervention period ≤ 12 weeks, exercise could significantly reduce the level of CRP (WMD,- 2.381 mg/ L; 95% CI,-4.835 to 0.073, P=0.001) and IL-10 (WMD,-7.141 pg/ml, 95% CI,-10.853 to -3.428; P=0.000) .In addition, aerobic exercise plus resistance training can significantly reduce the IL-6 level (WMD,-1.474 pg/ml; 95% CI,-1.653 to - 1.296; P=0.000). The results of sensitivity analysis showed that after excluding the high heterogeneity study, exercise can significantly reduce the level of TNF- α in patients with breast cancer (WMD, -1.399 pg/ml; 95%CI, -1.718 to -1.080; P=0.000).Conclusion: Exercise can reduce the levels of IGF-1, IL-6, CRP, IL-10 and TNF- α in woman with breast cancer. This may be due to the period or type of exercise.Registration number :INPLASY2021100101
Characterization of cavitation evolution in centrifugal pumps through motor current signal analysis
Authors: Sun Hui , Si Qiaorui , Yuan Shouqi 
Published: March 2022

Abstract
Cavitation detection is quite significant for safety and stability of centrifugal pump operation. In this research work, motor current signal analysis (MCSA) technique is improved to extract indicators for quantitative characterization of cavitation status. The method of Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) is preliminarily used for denoising and isolating Intrinsic Mode Functions (IMFs) containing cavitation characteristics from current signals. IMFs revealing pump operation are selected based on the concurrent frequency bands in spectrograms. IMFs are analyzed by Hilbert Transform to select the components that could reveal energy variation, so that the irrelevant components are removed. According to the feature analysis of cavitation, the peak value in marginal spectrum of IMF 6 is extracted to indicate incipient cavitation. And the peak value in marginal spectrum of IMF 7-8 is extracted as the indicator for characterization of cavitation evolution. Results of this research could provide technical assistance for pump cavitation detection.
Hydroxyzine dihydrochloride premedication is a necessity for pediatric patients undergoing strabismus surgery: An observational prospective clinical trial
Authors: Kartufan Fatma Ferda , Kizilcik Nurcan , Ziylan Sule , Menda Ferdi 
Published: March 2022

Abstract
Objective: In this single-blind, observational prospective trial we aimed to determine and compare the effect of premedication with hydroxyzine plus midazolam and midazolam alone on the incidence of Oculocardiac Reflex (OCR).Methods: Forty-five patients divided into three groups retrospectively after surgery; according to the oral premedication before surgerys. Group M received 0.5mg/kg midazolam alone, Group H received 0.5 mg/kg hydroxyzine plus 0.5 mg/kg midazolam, and Group HM received 1mg/kg hydroxyzine plus 0.5 mg/kg midazolam. The observational part of the study was carried out prospectively during surgery. The Ramsay Sedation Scale (RSS), the heart rates (HR1: after induction of anesthesia; HR2: before retraction of orbital muscle; and HR3: right after retraction of orbital muscle), the muscles with OCR and the incidence of OCR (20% decrease of the HR right after the traction) were recorded and compared between the three groups. Results: The mean HR1, HR2 and HR3 values were significantly increased (p=0.002, p<0.001, p<,0.001) and the incidence of OCR (p=0.004) was significantly decreased in the Group H, and in the Group HM (for all, p<0.01) compared to the Group M. No statistically significant difference was found between the Group H and Group HM in terms of RSS, HR1, HR2, HR3 and the incidence of OCR (for all, p>0.05). The most common orbital muscle in which OCR occurred was the rectus medialis. Conclusion: Premedication with a combination of 0.5 or 1 mg hydroxyzine with 0.5 mg midazolam significantly reduced the incidence of OCR compared to the premedication with midazolam alone.
Copula Function method of the kinematic accuracy of cylindrical roller bearing
Authors: lihong li , XUE Yujun , LI Jishun , Wang Weihang 
Published: March 2022

Abstract
The kinematic accuracy of cylindrical rollers bearing isn’t only influenced by the size and form precision of its parts, but also more influenced by the cooperation among them. For cylindrical rollers bearing, the main indices of the kinematic accuracy are the ending beat and the radial run out of bearings. There must be dependent relationship between the cooperative action among the parts of bearings and the ending beat or the radial run out of bearings. This relationship is hardly expressed by mathematical formula. However, because the parts dimension deviation and the run out of bearings follow statistic law and have their distribution characteristics, while the copula joint distribution function can connect the run out of bearings with multiple parts dimension accuracy. The copula function is introduced to analyze the dependent relationship between bearing parts cooperative action and its kinematic accuracy. Based on the copula function of statistic theory, the kinematic accuracy of bearings can be forecast by parts geometric accuracy.