bluuebunny/crossref_metadata_2025_split huggingface dataset:
Харківщина – історична українська земля
Authors: Бірьова Ольга 
Published: November 2022

В статті характеризується процес заселення Слобідського регіону, час будівництва міст та містечок. Досліджується національний склад мешканців та особливості культури регіону.
Метою даної статті є дослідження процесу заселення та формування Харківщини, як частини Слобідського регіону Східної України.
Методологія дослідження базується на історичних методах (історико-порівняльний, проблемно-хронологічний, діахронний, синхронного-аналізу). Для дослідження історичних джерел були використані методи критичного аналізу.
Наукова новизна. В статі аналізується процес заселення регіону та адміністративні зміни з давніх часів до ХХ ст. З’ясовано, що всі статистичні джерела доводять перевагу українського етносу в кількісному складі мешканців. Слобідський регіон не можна обмежувати виключно сучасними територія Східної України – це також території сучасних російських областей, які заселялися українськими козаками.
Висновок. Слобідська Україна – етнографічний регіон, сучасної Східної України та російських земель, який сформувався в результаті переселень мешканців Центральної і Західної України на Схід. В часи Київської Русі територія була населена слов’янськими племенами сіверян, які змушені були залишити територію після нападів кочовиків. Будівництво сучасних міст розпочалося з середини XVІІ ст. Міста будувалися українськими козаками, які приходили з інших регіонів України. Єдиним станом в Слобожанщині були козаки, до яких також відносилися міщани. В етнографічному відношенні домінував український етнос.
Українці принесли із собою полковий устрій, свою мову, культуру, ментальні особливості. Отже, Слобідська Україна – етнографічний регіон здавна заселений слов’янськими племенами та повторно заселений у середині XVІІ ст. українськими переселенцями.
Мілітарна проблематика: соціологічний дискурс
Authors: Кудринська Анна , Лапан Тетяна , Химович Оксана 
Published: November 2022

Події, що відбуваються у сучасній Україні, актуалізують мілітарну проблематику. Від об’єктивної оцінки ситуації, адекватності її сприйняття залежить майбутнє України як суверенної держави. Суттєвою у цьому аспекті є роль соціології як науки, що фокусується на осмисленні соціальної реальності, у нашому випадку - війни. Її наслідки відчутні не лише для України, а й для міжнародної спільноти.
Безпосереднє спостереження за подіями, які мають місце в українських реаліях, формують неоціненний досвід дослідника. Одна з особливостей соціології як науки полягає у її дослідницькій стратегії: системності та комплексності. З метою комплексного та системного аналізу російсько-української війни в статті пропонується розгляд мілітарної проблематики крізь призму мікро-, мезо-, макро- та мегарівневого підходів. Окреслений авторами дослідницький вектор простежується в тих емпіричних дослідженнях, які, від початку широкомасштабного вторгнення росії, реалізовані в Україні. Зокрема, йдеться про низку досліджень, проведених такими дослідницькими агенціями, як соціологічна група «Рейтинг», Info Sapiens, КМІС, Український центр економічних і політичних досліджень імені О. Разумкова, Factum Group Ukraine та ін.
У статті робиться висновок про те, що більшість досліджень, проведених в Україні за час широкомасштабного вторгнення росії, розкривають окремі аспекти проблематики війни; в основному, спрямовані на ситуативне та точкове визначення ситуації, аніж на її системне, комплексне вивчення. Зазначається, що простежується брак якісних соціологічних досліджень, що б уможливило ґрунтовніший аналіз означеної проблематики з метою подальших теоретичних узагальнень і конструктів.
Тенденції розвитку паблік рілейшнз в Україні: практичний досвід та нові виклики 2021-2022 р.р.
Authors: Горошко Олена , Меченкова Наталія 
Published: November 2022

Стаття присвячена опису нових підходів та особливостям PR-діяльності в Україні та аналізу PR-трендів, що склалися. На основі проведеного наприкінці 2021 року опитування експертів, зайнятих у різних сферах економіки, у контексті зіставлення низки секторів економіки, було виявлено, що багато тенденцій, які публічно обговорюють фахівці, як діджиталізація, розвиток соціальних медіа та ін. підтверджуються, однак, в окремих сферах мають більшу чи меншу ступінь інтенсивності, наприклад, той самий вплив і використання соціальних мереж, лідерів думок та репутаційного менеджменту.
У зв'язку з виявленими опитуванням тенденціями, в ході анкетування, більше питань було присвячено соціальним медіа, управлінню репутацією та особливостям, які згадували фахівці під час роботи з цими напрямами. Деякі ідеї, виділені експертами, не були підтверджені як трендові, серед них – зміни у роботі прес-служби. Загалом, опитування виявило більше подібних спостережень та оцінок, показало напрями та цікаві професіоналам кейси українських фахівців. На підставі отриманих даних можна говорити про трансформацію PR-ринку у 2021 році: більш креативна співпраця у структурі інтегрованих маркетингових комунікацій дозволяє впроваджувати у практику ширший та структурований підхід, отримувати більше кількісних та якісних показників ефективності, які можна вимірювати та аналізувати.
У 2022 році, у зв'язку з початком війни в країні, всі сфери зазнали істотних змін, і зараз поступово після вимушеної зупинки починають працювати і адаптуватися до поточної ситуації. Автори дотримуються думки, що на даному етапі – важливо визначити та описати основні виклики, щоб зрозуміти їх значущість та інтенсивність на розвиток як PR-ринку так і професії в цілому.
Essential microelement (copper, selenium, zinc) status according to age and sex in healthy cats
Authors: Sedláčková Karolína , Száková Jiřina , Načeradská Martina , Praus Lukáš , Tlustoš Pavel 
Published: November 2022

AbstractAlthough domestic cats are one of the most popular companion animals, current knowledge on the fate of micronutrients in cats according to their age, sex, and health is very limited. In this study, 72 whole blood and 54 plasma samples from cats of different ages and sex were collected at three veterinary offices in the Czech Republic, and the copper (Cu), selenium (Se), and zinc (Zn) concentrations were determined using inductively coupled plasma mass spectrometry (ICP-MS). The results showed that Cu was significantly (P < 0.05) higher in both plasma and whole blood of males (980 and 958 μg L−1 in plasma and whole blood, respectively) than in females (741 and 766 μg L−1 in plasma and whole blood, respectively), whereas no significant differences between males and females were found for Se and Zn. Similarly, no significant differences were recorded for any of the three elements according to age, although animals older than 7 years tended to have lower plasma concentrations of all three elements. Hypertrophic cardiomyopathy (HCM) is one of the most prevalent diseases of domestic cats. The potential relationship between the essential microelement status in the blood of cats with HCM vs. cats with no clinical signs of HCM was taken into account, but the limited number of HCM-positive individuals did not allow any clear conclusion. Thus, the potential relationships between micronutrient status in cats and the incidence of HCM should be elucidated in further research.
Determination of coumarin-3-carboxylic acid in the liver and heart tissue of Sprague-Dawley rats after intragastric administration of extractive of leaves of F. virens var. sublanceolata by HPLC
Authors: Xiang Yujie , Chuahe Bahetibieke , Zhang Jing , Li Jiansha , Jiang Xinhui 
Published: November 2022

AbstractThe study was aimed to validate and optimize high performance liquid chromatographic (HPLC) method for the determination of coumarin-3-carboxylic acid (C3A) in the heart and liver issue of Sprague-Dawley (SD) rats after intragastric administration of extractive of leaves of Ficus virens var sublanceolata. And simple ADME and target prediction analyses were performed for C3A. Ethyl acetate was employed to precipitate protein with appropriate sensitivity and acceptable matrix effects. The satisfactory separation was developed on an ODS2 column (4.6 mm × 250 mm, 5 μm) by gradient elution with a methanol-acetic acid solution (pH = 3.0) as the mobile phase. The flow rate was 1.0 mL min−1, the column temperature was maintained at 30 ± 2 °C, the injection volume was 20 μL, and the detection wavelength was set as 309 nm. The method was fully validated in terms of selectivity, linearity, accuracy, precision, extraction recovery and stability. The results of the ADME analysis found that C3A has excellent characteristics of drug-likeness, consistent with good bio-absorption. And the predicted 12 target protein belongs to the amine oxidoreductase and carbonic anhydrase target class. This method is simple, rapid, sensitive, and accurate for the determination of coumarin-3-carboxylic acid in the heart and liver tissue of SD rats.
Deep Residual Adaptive Neural Network Based Feature Extraction for Cognitive Computing with Multimodal Sentiment Sensing and Emotion Recognition Process
Authors: Arora Gopal , Sabharwal Munish , Kapila Pooja , Paikaray Divya , Vekariya Vipul , T Narmadha 
Published: November 2022

For the healthcare framework, automatic recognition of patients’ emotions is considered to be a good facilitator. Feedback about the status of patients and satisfaction levels can be provided automatically to the stakeholders of the healthcare industry. Multimodal sentiment analysis of human is considered as the attractive and hot topic of research in artificial intelligence (AI) and is the much finer classification issue which differs from other classification issues. In cognitive science, as emotional processing procedure has inspired more, the abilities of both binary and multi-classification tasks are enhanced by splitting complex issues to simpler ones which can be handled more easily. This article proposes an automated audio-visual emotional recognition model for a healthcare industry. The model uses Deep Residual Adaptive Neural Network (DeepResANNet) for feature extraction where the scores are computed based on the differences between feature and class values of adjacent instances. Based on the output of feature extraction, positive and negative sub-nets are trained separately by the fusion module thereby improving accuracy. The proposed method is extensively evaluated using eNTERFACE’05, BAUM-2 and MOSI databases by comparing with three standard methods in terms of various parameters. As a result, DeepResANNet method achieves 97.9% of accuracy, 51.5% of RMSE, 42.5% of RAE and 44.9%of MAE in 78.9sec for eNTERFACE’05 dataset. For BAUM-2 dataset, this model achieves 94.5% of accuracy, 46.9% of RMSE, 42.9%of RAE and 30.2% MAE in 78.9 sec. By utilizing MOSI dataset, this model achieves 82.9% of accuracy, 51.2% of RMSE, 40.1% of RAE and 37.6% of MAE in 69.2sec. By analysing all these three databases, eNTERFACE’05 is best in terms of accuracy achieving 97.9%. BAUM-2 is best in terms of error rate as it achieved 30.2 % of MAE and 46.9% of RMSE. Finally MOSI is best in terms of RAE and minimal response time by achieving 40.1% of RAE in 69.2 sec.
High BMI causing poor outcome of intrauterine insemination method
Authors: Baldawa Pratibha , Baldawa Sampat 
Published: November 2022

To assess whether high BMI of &#62;30kg/m2 affects outcome of Intrauterine Insemination method(IUI). We conducted a retrospective study of 140 infertile couples. Out of these 71 women had BMI &#60;30 (Group A) and 69 women had BMI of &#62;30 (Group B). All these 140 women had undergone Intrauterine Insemination (IUI) using the agonist/antagonist with stimulation by gonadotrophins protocol. Statistical anylasis was done by Student t test for parametric data and Chi-square test for p value significance. We found that success of Intrauterine Insemination (IUI) was higher in women with BMI &#60; 30. We had 16 pregnancies (22.54%) with 3 patients having twin pregnancy (4.23%) in Group A and only 3 patients (4.34%) were pregnant in the group B. There was a significant (p = 0.002) decrease in pregnancy rate in women with BMI of &#62;30 who underwent Intrauterine Insemination(IUI).
A study of postnatal depression in a tertiary care centre – A prospective observational study
Authors: Preethi Bhuvana , Vijayakrishnan Mala , Nagarajan Prasanth 
Published: November 2022

Postnatal depression is defined as non-psychotic depressive episodes of mild to major severity which occurs during pregnancy or postpartum. It is one of the most common non obstetric disorders that causes significant morbidity in women during the perinatal period. It is often unrecognized, but an extremely common yet a disorder (100-150 per 100 births) and is prevalent among Indian women up to 19% - 22% as well. The aim of this study is to find out incidence of postnatal depression in Vijaya Hospital, a private tertiary care hospital. This study aims at identifying the incidence of postnatal depression in postnatal mothers in a tertiary care centre using Edinburg Postnatal Depression Scale (EPDS) questionnaire and the risk factors contributing to postpartum depression. The results were incidence of postnatal depression at week one was 40% and week four was 27%.: It is a prospective observational study with a sample size of 100. Postnatal mothers were screened using EPDS questionnaire at one week when they are admitted in hospital and four weeks when they come for postnatal checkup. Women with EPDS score of 13 and above was considered having Postpartum Depression. Age, socioeconomic status, educational status, employment status, type of family, menstrual history, premenstrual syndrome, obstetric score, mode of delivery, planning of pregnancy, relationship with parents, in laws and partner was compared at one week and four weeks.The Primary outcome of the study was to measure the incidence of PPD at week one which was 40% and week four which was 27%. The secondary outcome identified the risk factors contributing to PPD in my study was menstrual history, mode of delivery, relationship with in laws, lack of partner support which was found to be statistically significant. In my study done in a private tertiary care hospital, the cumulative incidence of PPD was 52%. Delivery through Caesarean section, menstrual history and poor relationship with in laws at one week was found to be statistically significant with a p-value of &#60;0.05. Lack of partner support at one week and four weeks were found to be statistically significant with a p- value of &#60; 0.05.
Functional and cosmetic outcome in oculofacial trauma at tertiary center- multidisciplinary approach
Authors: Ramnani Vinita , Ramnani Sakshi , Rathore Sunil , Sharma Nupun 
Published: November 2022

To assess the outcome of lid, adnexal and orbital injuries in poly trauma patients at multi specialty hospital. Papers of 104 consecutive patients with oculofacial injuries were retrospectively reviewed. Data were analyzed with respect to extent, severity, type and location of oculofacial injury. Treatment outcome assessed after surgeries performed by combined approach of ophthalmologist and plastic surgeon. Periorbital soft tissue trauma observed in 65 (62.5%), orbital and Periorbital fracture in 39 (37.5%) cases and Intraocular injuries were noted in 43 patients (41.35 %). Accompanying other injuries was managed properly for better final outcome. Goal of repair is to restore anatomical and cosmetic appearance of patients. In our series of patients, we achieved 95% cosmetic satisfaction with loss of 5 eyes vision with best of our care. The oculofacial trauma patients have tremendous fear of visual loss and aesthetic appearance. Functional and cosmetic outcome of oculofacial injuries depends on multiple factors, well planned, appropriate, early intervention by multidisciplinary approach provides best surgical outcome.
Characterization of Nonlinear Viscoelastic Properties of Enhanced Oil Recovery Polymer Systems Using Steady-Shear Rheometry
Authors: Azad Madhar Sahib 
Published: November 2022

SummaryEnhanced oil recovery (EOR) polymer systems such as hydrolyzed polyacrylamide (HPAM) solutions flowing in porous media at high fluxes were reported to cause shear-thickening, a nonlinear viscoelastic (NLVE) phenomenon. Bulk rheological studies are usually performed to characterize the viscous and viscoelastic behaviors of polymer solutions in porous media. To characterize the viscoelastic properties, oscillatory shear rheology based on linear viscoelastic (LVE) data and extensional rheology based on NLVE data have been used. Although both extensional flow and high-speed shear flow can stretch and thicken polymer solutions in a nonlinear fashion, steady-shear rheometry has been used to measure only the viscous and thinning behavior of HPAM systems. In this paper, (a) the thickening ability of HPAM polymer systems formulated with contrasting salinity and molecular weight (MW) concentration is characterized in bulk shear rheometry to analyze if the thickening in the pure shear field correlates with the thickening behavior reported in porous media and other rheometry and (b) the thickening intensity of the polymer solutions of varying salinity concentration in the bulk shear field is compared with the reported mechanical degradation effects in the literature.The shear-thickening index obtained by fitting a power-law model to thickening data in steady-shear rheograms is higher for the high-saline, high-MW low-concentration HPAM systems that have inherently higher nonlinear viscoelasticity. Furthermore, the thickening behavior observed due to salinity variation in bulk steady shear contrasts with linear oscillatory shear behavior but conforms to the thickening behavior observed in porous media and in the extensional field. This signifies that polymer-EOR researchers performing comparative studies on low-salinity and high-salinity polymer floods, and having a shear rheometer at their disposal, must look beyond linear oscillatory rheology and make use of nonlinear steady-shear rheology. There is a direct relation between the shear-thickening index of saline HPAM solutions and their mechanical degradation intensity. This paper shows that the high-speed data in steady-shear rheometry that are usually ignored in EOR literature have useful information and the notion that HPAM solutions are purely thinning in the bulk shear field needs to be reconsidered.
Peripheral blood CD86-positive plasmacytoid dendritic cells and immune-related adverse events in lung cancer patients
Authors: Karayama Masato , Mizoguchi Yukihiro , Inoue Yusuke , Hozumi Hironao , Suzuki Yuzo , Furuhashi Kazuki , Fujisawa Tomoyuki , Enomoto Noriyuki , Nakamura Yutaro , Inui Naoki , Suda Takafumi , Kitano Shigehisa , Aoki Kazunori , Yamada Yasuhide 
Published: November 2022

Abstract
Background: The immune-related adverse events (irAEs) is unpredictable. Peripheral blood mononuclear cell (PBMC) profiles have potential for predicting irAEs.
Methods: PBMCs were measured using multicolor flow cytometry before and at weeks 2 and 8 after the immune checkpoint inhibitors (ICIs) in lung cancere patients.
Results: Sixteen patients were eligible for the analysis. The irAEs occurred in 6 (37.5%) patients. Patients with irAEs demonstrated higher levels of CD86+plasmacytoid dendritic cells (pDCs) at baseline and weeks 2 and 8 after the ICIs than patients without irAEs (p = 0.005, 0.038, and 0.050, respectively). Higher levels of natural killer (NK) cells were significantly associated with overall objective response (p = 0.024).
Conclusions: Higher levels of CD86+pDCs at baseline and the reduction at 2 and 8 weeks after the ICIs were associated with the occurrence of irAEs. Higher levels of NK cells were associated with therapeutic efficacy. Measurements of PBMCs may be useful for predicting the efficacy and safety of ICIs.
Exosomal circRNA-miRNA Expression profile from plasma in Alzheimer’s Disease Patients by Bioinformatics and Integrative Analysis
Authors: Besli Nail , Sarikamis Bahar , Cakmak Rabia Kalkan , Kilic Ulkan 
Published: November 2022

Abstract
Background Alzheimer's disease (AD) is an age-dependent neurodegenerative ailment globally. Compelling evidence suggests the function of exosomal non-coding RNAs has been associated with the progression of AD but whose exosomal-linked non-coding RNAs mediated regulatory mechanisms are broadly unlit. This study, therefore, set out with the aim of exploring the exosomal circRNA-miRNA networks in the plasma of AD patients.
Methods and Results Data of 3 samples from each group (healthy, mild cognitive impairment (MCI), and AD) were fetched from ArrayExpress. The MCI and AD groups were compared with the healthy group by screening for differentially expressed miRNAs (DEmiRs) and circRNAs (DEcircRs) in plasma exosomes. Subsequently, common DEmiRs and DEcircRs for both MCI and AD groups were evaluated to identify gene ontologies, pathways, and networks. Lastly, the analysis of the PPI (protein–protein interaction) network and hub genes selection were performed. A total of common 19 (7 upregulated and 12 downregulated) DEmiRs and 24 DEcircRs were identified. It was predicted 4559 target genes for upregulated DemiRs, while 6504 target genes for downregulated DEmiRs and most of the target genes were associated with the PI3K-Akt pathway and that they were mostly regulated by hsa-mir-615-3p, hsa-mir-196a-5p, hsa-let-7c-5p, hsa-let-205-5p, hsa-mir-185-3p, hsa-mir-185-5p, hsa-mir-374a-5p, hsa-mir-374a-3p. Also, 9 hub genes (CCNE2, CCND1, CDK6, ACTB, MAPK1, AKT1, GSK3B, IGF1R, HSP90AA) were uncovered as the genes most associated with AD by a PPI network using Cytoscape plug-in cytohubba.
Conclusions Our outcomes exhibit a new outlook on a possible exosomal-linked miRNA-circRNA network in the pathogenesis of AD.
C/D box small nucleolar RNA SNORD104 promotes endometrial cancer by regulating the 2'-O-methylation of PARP1
Authors: Lu Bingfeng , Chen Xi , Liu Xin , Chen Jingwen , Qin Honglei , Chen Shuo , Zhao Yang 
Published: November 2022

Abstract
Background: Small nucleolar RNAs (snoRNAs) are dysregulated in many cancers, although their exact role in tumor genesis and progression remains unclear.
Methods: The expression profiles of snoRNAs in endometrial cancer (EC) tissues were analyzed using data from The Cancer Genome Atlas, and SNORD104 was identified as an upregulated snoRNA in EC. The tumorigenic role of SNORD104 in EC was established in CCK8, colony formation, EdU, apoptosis, Transwell, and in vivo xenograft experiments. The molecular mechanisms of SNORD104 were analyzed by RNA immunoprecipitation (RIP), Nm-seq, RTL-P assay, RNA stability assay, qRT-PCR, and western blotting.
Results: Antisense oligonucleotide (ASO)‑mediated knockdown of SNORD104 in Ishikawa cells significantly inhibited their proliferation, colony formation ability, migration, and invasion in vitro and increased apoptosis. On the other hand, overexpression of SNORD104 promoted EC growth in vivo and in vitro. RIP assay showed that SNORD104 binds to the 2'-O-methyltransferase fibrillarin (FBL), and according to the results of Nm-seq and RTL-P assay, SNORD104 upregulated PARP1 (encoding poly (ADP-ribose) polymerase 1) 2'-O-methylation. The binding of FBL to PARP1 mRNA was also verified by ROP assay. Furthermore, SNORD104 expression was positively correlated with PARP1 expression in EC tissues. In the presence of actinomycin D, SNORD104 increased the stability of PARP1 mRNA and promoted its nuclear localization. Finally, silencing FBL or PARP1 in the HEC1B cells overexpressing SNORD104 inhibited their proliferative and clonal capacities and increased apoptosis rates.
Conclusions: SNORD104 enhances PARP1 mRNA stability and translation in the EC cells by upregulating 2'‑O‑methylation and promotes tumor growth.