bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reassessing the performance of the “step-by-step” approach to febrile infants aged 90 days and younger in the context of the COVID-19 pandemic: a multicentric retrospective study
Authors: Rybak Alexis , Aupiais Camille , Cotillon Marie , Basmaci Romain , de Pontual Loïc , Bonacorsi Stéphane , Mariani Patricia , Landraud Luce , Brichler Ségolène , Poilane Isabelle , Ouldali Naïm , Titomanlio Luigi 
Published: March 2022

Abstract
BackgroundInfants with COVID-19 can often present with fever without source which is a challenging situation in infants < 90 days old. The “step-by-step” algorithm has been proposed to identify children at high risk of bacterial infection. In the context of the COVID-19 pandemic, we aimed to reassess the diagnostic performance of this algorithm.MethodsWe performed a multicentric retrospective study in 3 French pediatric emergency departments between 2018 and 2020. We applied the “step-by-step” algorithm to four clinical entities: COVID-19, febrile urinary tract infections (FUTI), invasive bacterial infection (IBI), and enterovirus infections. The main outcome was the proportion of infants classified at high risk.ResultsAmong the 199 infants included, 40 had isolated COVID-19, 25 had IBI, 60 had FUTI, and 74 had enterovirus infection. All but one infant with bacterial infection were classified at high risk (96% for IBI and 100% for FUTI) as well as 95% with enterovirus and 82% with COVID-19. Infants with COVID-19 were classified at high risk because an ill appearance (72%), an age ≤ 21 days (27%) and/or leukocyturia (19%). All these infants had procalcitonin values < 0.5 ng/mL and only one had C-reactive protein level > 20 mg/L.ConclusionsThe “step-by-step” algorithm remains effective to identify infants with bacterial infection but misclassifies most infants with COVID-19 as at high risk of bacterial infection leading to unnecessary cares. An updated algorithm based adding viral testing may be needed to discriminate fever related to isolated COVID-19 in infants < 90 days old.
Turing patterns with high-resolution formed without chemical reaction in thin-film solution of organic semiconductors
Authors: Li Shunpu , Xiang Zezhong , Li Jin , You Peng , han Linbo , Qiu Mingxia , Chen Gengliang , He Yu , Xiang Boyuan , Su Yaorong , An Hongyu 
Published: March 2022

Abstract
Regular patterns can form spontaneously in chemical reaction-diffusion systems under non-equilibrium conditions as proposed by Alan Turing. Here, we found that regular patterns can be generated in uphill-diffusion solution systems without a chemical reaction process through both in-situ and ex-situ observations. Organic semiconductor solution is confined between two parallel plates with controlled micron/submicron-meter distance, to minimize convection of the liquid and avoid spinodal precipitation at equilibrium. The solvent evaporation concentrates the solution gradually into an oversaturated non-equilibrium condition, under which a phase-transition occurs and ordered concentration-waves are generated. By proper tuning of the experimental parameter, multiple regular patterns with micro/nano-meter scaled features (line, square-grid, zig-zag, and fence-like patterns etc.) were observed. We explain the observed phenomenon as Turing-pattern generation resulted from uphill-diffusion and solution oversaturation. The generated patterns in the solutions can be condensed onto substrates to form structured micro/nanomaterials. We have fabricated organic semiconductor devices with such patterned materials to demonstrate the potential applications. Our observation may serve as a milestone in the progress towards a fundamental understanding of pattern formation in nature, like in biosystem, and pave a new avenue in developing self-assembling techniques of micro/nano structured materials.
The resilience of nursing staffs in nursing homes: Concept development of a hybrid model
Authors: CHANG Sung Ok , KIM Eun Young 
Published: March 2022

Abstract
Aim
To identify the definition and conceptual characteristics of the concept of resilience of nursing home (NH) nursing staffs.
Method
In this study, the concept was developed using a hybrid model that included theoretical, fieldwork, and final analysis stages. In the theoretical stage, a literature review on the definition and measurement of concepts was performed. For the fieldwork stage, in-depth interviews with seven NH nursing staff members were performed. During the final analysis stage, the results of the theoretical and field work stages were integrated.
Results
Three dimensions, eight attributes, and three types were identified. The three dimensions are internal resources, external support, and positive coping with situations as they arise; the eight attributes are optimism, patience, mindfulness, supportive relationships, available resources, work-life boundary setting, self-development, and growth; and the three types are those who want to adapt themselves to the situation, those who actively seek to cope with stressful situations, and those who hold positive expectations for the future.
Conclusion
Coping with difficult situations using internal resources and external support was a unique trait revealed in the resilience of NH nursing staff members. This study provided future research directions to improve the resilience of NH nursing staffs by revealing the characteristics of their resilience.
Application of PID control based on bacterial foraging-particle swarm hybrid algorithm optimization in variable fertilization system
Authors: Changxin Fu , Lixin Zhang , Xiao Ma , Huaisheng Li 
Published: March 2022

Abstract
In the irrigation process and fertilization process of agricultural production, the accuracy of fertilizer application and water use is kept at a relatively low level, which leads to soil slumping and waste of resources. In order to solve the above problems, this study investigates the demand for fertilizer application accuracy in the field and builds a mathematical model of variable fertilizer application system. Considering a large number of defects of the system, such as poor fertilization accuracy, long response time, and unstable regulation process, combined with MATLAB/Simulink platform, this study designs a PID algorithm based on bacterial foraging-particle swarm hybrid algorithm to control the fertilization and irrigation process of the variable fertilizer applicator. The precise fertilization control of the variable fertilizer system is mainly studied and the fuzzy proportional integral differential gain parameters of the variable fertilizer system by the hybrid algorithm are optimized. By comparing with the control algorithms (proportional-integral differential control, fuzzy proportional-integral differential control, and proportional-integral differential control with particle swarm optimization) commonly applied in the current fertilizer application system, the comparison results demonstrate that the control algorithm in this paper has better regulation, smaller overshoot, excellent stability and more rising steady-state time deficit, which can realize the precise control of the fertilizer system. Finally, this study designed fertilizer application accuracy tests under different pressure values. The results show that the algorithm proposed in this study has high fertilizer application accuracy under different pressures, which greatly reduces the waste of resources in the process of fertilizer application for crop irrigation.
Comparing the Efficacy and Safety of Cisplatin and other Platinum-based Chemotherapy in Locally Advanced Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis
Authors: Kang Min , Li Zhiru , Li Chao , Yang Dong , Song Junmei , Liu Ting , Zhou Ziyan 
Published: March 2022

Abstract
Objectives: Cisplatin-based concurrent chemoradiotherapy has been identified as the primary and standard treatment for locally advanced nasopharyngeal carcinoma (NPC). The side effects of cisplatin affect the compliance to therapy. Thus, the search for a platinum-based substitute for NPC has always been a research focus. However, there is a variability in the efficacy of different platinum-based chemotherapy in the treatment of NPC. We performed a meta-analysis to compare between the efficacy and safety of the cisplatin-based regimens and the other platinum-based derivatives (carboplatin, nedaplatin, and lobaplatin) for locally advanced NPC. Methods: PubMed, EMBASE, Cochrane Library, Web of Science, and ClinicalTrials.gov were systematically searched for all potentially eligible clinical trials as of February 15, 2022. The pooled hazard ratios, risk ratio, and 95% confidence interval were calculated using the Review Manager Software version 5.4. Results: A total of 1,907 patients with locally advanced NPC were eligible from the 1,265 retrieved records. This systematic review included eight articles, six of which were randomized controlled clinical trials. There was no significant difference in the 3- and 5-years overall survival, progression-free survival, distant metastasis-free survival, and locoregional relapse-free survival between cisplatin-based chemotherapy and other platinum-based chemotherapy. Severe acute hematological side effects (≥ grade 3) during treatment, such as neutropenia, leukopenia, and thrombocytopenia, are equivalent in both groups. However, the incidence of anemia is higher in patients receiving other platinum-based chemotherapy. Moreover, the risks of nausea, vomiting and weight loss were higher in the cisplatin group but there was no significant difference in the other non-hematological and late side effects between the two groups. Conclusion: Other types of platinum-based chemotherapy are as effective as cisplatin-based chemotherapy in the treatment of locally advanced NPC, thus acting as potential alternatives to cisplatin. Further studies providing high-level evidence are needed.
Utilization of long –acting contraceptive methods and associated factors among female health-care providers in South Wollo Zone hospitals, North East, Ethiopia. A cross sectional multicenter study
Authors: seid Mehdi , Yimer Aragaw , seid Ahmed , Fantaye Fasil , Damtie Yitayshi 
Published: March 2022

Abstract
Back ground: - Long-acting contraception method utilization was found low (22.7%) among female health care providers. However, to the best of our knowledge no study has been conducted on utilization long-acting contraception methods among female healthcare providers in the study area. These studies addressed important variable such as socio-demography and individual factors that might affect the use of long-acting contraceptive methods among female healthcare providers, but, limited studies have been in Ethiopia. Objective: - To assess the utilization of long-acting contraceptive methods and associated factors among healthcare providers in South Wollo Zone public hospitals, Amhara Region, Ethiopia 2021.Methods: An institutional-based cross-sectional study was conducted among 354 female healthcare workers in hospitals in the South Wollo Zone from March to April 22, 2021. The participants were selected using systematic random sampling technique. The data were collected using self-administered questionnaires. The data were entered Epi-data version 4.1 and export to SPSS versions 25 for analysis. Bivariable and multivariable logistic regression analyses were also performed. The Adjusted odds Ratio (AOR) along with a 95% confidence interval (CI) were estimated to measure the association and level of significance was declared at a P- value of less than 0.05.Result: -The current utilization of long-acting contraceptive methods among female health care providers was found to be 33.6% [95%, CI 29-39)], discuss with partner [AOR= 2.277,95% CI, (1.026-5.055)], method shift/switched [AOR=4.302,95% CI, (2.285-8.102)], knowledge of respondent [AOR= 1.887,95% CI, (1.020-3.491)], ever birth [AOR=15.670,95% CI, (5.065-48.49)] were significant factors towards the utilization of long-acting contraceptive methods. Conclusion and recommendation: -The current utilization of long-acting contraceptive methods was found low. Discus with partner, methods shift/switching, ever birth and knowledge of respondents were identified as significant factor. Therefore, encouraging partner discussion targeted Information Education Communication Intervention should be intensified to improve long-acting contraceptive methods utilization.
The Simplified Tailor-made Workflows for a 3D Slicer-based Craniofacial Implant Design
Authors: Tantisatirapong Suchada , Khunakornpattanakarn Sarunyapong , Suesatsakul Thanyakarn , Boonpratatong Amaraporn , Benjamin Itsara , Tongmeesee Somprasong , Kangkorn Tanasit , Chanwimalueang Theerasak 
Published: March 2022

Abstract
A specific design of craniofacial implant model is vital and urgent for traumatic head injury. A mirror technique is conventionally employed for modelling. However, such method requires healthy skull region identically opposite to a defect. We therefore propose the three processing workflows for modelling implants: mirror, baffle planner and baffle-based mirror guideline. The workflows are based on implementing extension modules on the 3D Slicer platform. We investigated the craniofacial CT datasets collected from the four accidental cases. The designed implant models were created from conducting the three workflows and compared to the reference models created by the experienced neurosurgeon. The spatial properties-based performance metrics were evaluated. The results show that the mirror method suits craniofacial cases whereby healthy skull region can be completely reflected to the defect region. The baffle planner module offers a flexible prototype model fit independently to any defect location. However, the baffle planner method requires customized refinement of contour and thickness to fill the missing region seamlessly. The process also relies on a user’s experience and expertise. The proposed baffle-based mirror guideline method strengthens the baffle planner method by tracing the mirrored surface. Such three proposed workflows simplify craniofacial implant modelling and can practically be employed for a variety of craniofacial scenarios.
Magma ascent and degassing processes of the 2011 and 2017-18 eruptions of Shinmoedake in Kirishima volcano group, Japan, based on petrological characteristics and volatile content of magmas
Authors: Saito Genji , Oikawa Teruki , Ishizuka Osamu 
Published: March 2022

Abstract
The eruption activity of Shinmoedake in the Kirishima volcanic group of Japan resumed in 2017–18 after a quiet period that lasted between 2011 and 2017. Subplinian eruptions preceded lava effusion in 2011; however, no subplinian eruption occurred in 2017–18. Petrological studies and melt inclusion analyses were conducted to investigate the ascent and degassing of the magma to understand the cause of the different eruption styles. Chemical analysis of the melt inclusions from the 2011 eruption indicates that mafic magma with high volatile content (6.2 wt% H2O, 1.4–0.25 wt% CO2) ascended into the shallow felsic magma (3.7–1.9 wt% H2O, 0.048–0.025 wt% CO2) at depths of 4–5 km. Calculations indicate that the mafic magmas were of lower density (1717–1835 kg m-3) than the felsic magma (2264–2496 kg m-3) at 125 MPa and that the two magmas were mixed. The 2011 mixed magma with high volatile content (4.0 wt% H2O, 0.14–0.70 wt% CO2) had a bubble volume of approximately 50 vol% at 50 MPa, which is likely to have caused the subplinian eruption. The whole-rock and chemical compositions of the plagioclase-, clinopyroxene-, and orthopyroxene phenocryst cores were similar in 2018 and 2011, suggesting that the 2018 magma was a remnant of the 2011 magma. Chemical analyses of the groundmass from 2018 and the MELTS calculation indicate that the magma approached chemical equilibrium over the period 2011 to 2018. Melt inclusion analyses and volcanic gas observation gave a lower bulk volatile content for the 2018 magma (3.0–2.1 wt% H2O, 0.10–0.087 wt% CO2) compared to the 2011 magma. Comparison of the degassed-magma volumes estimated from the S and Cl contents of the melt inclusions, SO2 flux and volcanic gas composition, and erupted-magma volume indicates that excess degassing has been occurring in the magma due to convection since March 2011, which may have decreased the volatile content of the magma. The relatively low volatile content meant that the 2018 magma could not erupt explosively and lava was instead erupted via effusion.
AIGDR: An Artificial Intelligence Framework for Disability Research – A Multiple Sclerosis Case
Authors: Aleid Maha , Alfantoukh Lina , Alarfaj Ohud , Alzeer Abdulla , Abomelha Eng. Faris 
Published: March 2022

Abstract
Background: Artificial intelligence (AI) is becoming an essential tool in the disability world. AI can be applied in a variety of contexts and domains, ranging from assistive devices for disabled individuals to decision-making systems that aid healthcare providers in the diagnosis and treatment of disabilities. Examples of these contexts include discrimination of behaviors, identifying and assessing disability-related problems, detecting abnormalities, classifying disabling diseases, predicting the progression of disabilities, and assisting and triaging patients.Methods: We investigated which AI predictive analytics models and features have been used in disability research locally and globally, focusing on multiple sclerosis. This allowed us to test multiple algorithms to determine which was best suited for each kind of data available locally. Results: We developed a framework called Artificial Intelligence Group for Disability Research (AIGDR) for disability-related research at King Salman Centre for Disability Research. The framework was influenced by existing AI use in disability research. Conclusions: The AIGDR framework uses existing predictive analytics models to generate dashboards and reports for decision-makers and produce a database that can help researchers conduct research. In the future, we plan to develop the proposed platform and apply it in various disability contexts in Saudi Arabia.
Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells degranulation model and network pharmacology
Authors: Ren Conglin , Li Mingshuang 
Published: March 2022

Abstract
Background: Baicalin is widely used in clinical practice. The present study aimed to assess the underlying mechanism of baicalin in treatment of atherosclerosis (AS) with the help of network pharmacology, molecular docking and experimental validation. Materials and methods: The target genes of baicalin and AS were identified from public databases, and the overlapping results were considered to be baicalin-AS targets. Core target genes of baicalin were obtained through the PPI network and clinical data sets GSE132651. Human aortic endothelial cells (HAECs) were treated with baicalin, followed by Lipopolysaccharide (LPS) to construct a model of endothelial injury. The expression of core targets was examined by real-time qPCR. Flow cytometry was used to detect reactive oxygen species (ROS) level. Results: NOX4 is likely to be the core target of baicalin for AS, and its expression was inhibited in AS patients compared to controls. Functional enrichment analysis demonstrated that most targets were involved in oxidative stress. Intervention with baicalin increased the expression levels of NOX4 and NOS3 (eNOS). Moreover, baicalin also blocked the LPS-induced ROS generation in HAECs. Conclusions: Baicalin might ameliorate oxidative stress on endothelial cells via targeting NOX4.
Quercetin treatment protects the Achilles tendons of rats from oxidative stress induced by hyperglycemia
Authors: Mifune Yutaka , Yoshikawa Tomoya , Inui Atsuyuki , Nishimoto Hanako , Yamaura Kohei , Mukohara Shintaro , Shinohara Issei , Kuroda Ryosuke 
Published: March 2022

Abstract
BackgroundQuercetin, a flavonoid abundantly in vegetables and fruits, exerts antioxidant and anti-inflammatory effects. We investigated the protective effects of quercetin against oxidative stress in the Achilles tendons of diabetic rats.MethodsCells were collected from the Achilles tendons of Sprague–Dawley rats and cultured under four conditions: regular glucose (RG) without quercetin (Quer-), RG with quercetin (Quer+), high-glucose (HG) Quer-, and HG Quer+. The expression of genes related to NADPH oxidase (NOX) and inflammation, reactive oxygen species accumulation, and apoptosis rates was analyzed. Additionally, diabetic rats were divided into two groups and subjected to quercetin (group Q) or no quercetin (group C) treatment. Histological evaluation and expression analysis of relevant genes in the Achilles tendon were performed.ResultsIn rat tendon-derived cells, the expression of Nox1, Nox4, and Il6; reactive oxygen species accumulation; and apoptosis rates were significantly decreased by quercetin treatment in the HG group. The collagen fiber arrangement was significantly disorganized in the diabetic rat Achilles tendons in group C compared with that in group Q. The mRNA and protein expression levels of NOX1 and NOX4 were significantly decreased upon quercetin treatment. Furthermore, the expression of Il6, type III collagen, Mmp2, and Timp2 was significantly decreased, whereas that of type I collagen was significantly increased in group Q compared with that in group C.ConclusionsQuercetin treatment decreases NOX expression and thus exerts antioxidant and anti-inflammatory effects in the Achilles tendons of diabetic rats. Quercetin treatment may be effective against diabetic tendinopathy.
GPOFWA: A hybrid greedy political optimizer with fireworks algorithm for numerical and engineering optimization problems
Authors: Dong Jian , Zou Heng , Li Wenyu , Wang Meng 
Published: March 2022

Abstract
This paper proposes a novel hybrid optimization algorithm named GPOFWA, which integrates political optimizer (PO) with fireworks algorithm (FWA) to solve numerical and engineering optimization problems. The original PO uses subgroup optimal solutions such as party leaders and constituency winners to guide the movement of the search agent. However, the number of such subgroup optimal solutions is limited, which leads to insufficient global exploration capabilities of PO. In addition, the recent past-based position updating strategy (RPPUS) of PO lacks effective verification of the updated candidate solutions, which reduces the convergence speed of the algorithm. The proposed hybrid algorithm uses the spark explosion mechanism in FWA to perform explosion spark and Gauss explosion spark operations on the subgroup optimal solutions (party leader and constituency winner) respectively based on the greedy strategy, which optimizes the subgroup optimal solution and enhances the exploitative ability of the algorithm. Moreover, Gaussian explosion sparks are also used to correct the candidate solutions after RPPUS, which makes up for the shortcomings of the original PO. In addition, a new subgroup optimal solution called the Converged Mobile Center (CMC) based on two-way consideration is designed to guide the movement of search agents. We test the presented hybrid algorithm on 30 well-known benchmark test functions and three engineering optimization problems. The experimental results show that GPOFWA is superior to nine state-of-the-art methods in terms of the quality of the resulting solution.