bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occupational (In)visibility: The emerging role of the Remote Education Tutor as an educational conduit
Authors: Peel K. L. , McLennan B. , Danaher P. A. , Burnett E. 
Published: October 2022

AbstractRemote Education Tutors (RETs) are central to the delivery of distance schooling in Australia and are accountable for the face-to face supervision and educational support of students. They act as the government mandated adult supervisors of Australian primary and secondary school students enrolled in distance education, including geographically isolated learners. This paper draws on statistical data from a national survey (N = 575) that was designed to map the perceptions of Australian RETs. These data confirmed that RETs act as a conduit between the distance schooling teacher and student, and that their role requires complex capabilities to be performed within a structured framework. Time restrictions with competing demands present a constant challenge to the RETs’ work satisfaction. Constraining this occupation is the reality that there is no formal qualification available for RETs. Without specific credentialling, it appears that the RETs’ (in)visible role risks being overlooked as a substantive educational occupation.
Monitoring of anti-drug antibodies and disease-specific biomarkers in three patients from a Japanese Fabry family treated with enzyme replacement therapy
Authors: Kubota Takao , Tsukimura Takahiro , Shiga Tomoko , Togawa Tadayasu , Sakuraba Hitoshi 
Published: October 2022

AbstractWe monitored anti-drug antibodies and disease-specific biomarkers in three patients with a nonsense mutation from a Japanese Fabry family treated with enzyme replacement therapy (ERT). In two male patients from the family, neutralizing anti-drug antibodies were induced at an early stage of ERT, the antibody titer peak being found at an earlier stage of ERT in the patient treated with 1.0 mg/kg agalsidase beta than in that treated with 0.2 mg/kg agalsidase alfa. Then, the antibody titers decreased with continuation of ERT. The formation of neutralizing anti-drug antibodies adversely affected the plasma globotriaosylsphingosine (Lyso-Gb3) level and urinary globotriaosylceramide (Gb3) excretion in both patients, the impact being greater in the patient treated with 0.2 mg/kg agalsidase alfa than in that treated with 1.0 mg/kg agalsidase beta. The difference might be explained by the different doses of the infused enzymes based on supersaturation of the antibodies. In a heterozygous Fabry female from the family, no sign of antibody formation was found, and both the plasma Lyso-Gb3 level and urinary Gb3 excretion, which were moderately increased at the baseline, decreased gradually. No deterioration of the manifestations or laboratory findings was observed during ERT in either of the patients. Thus, monitoring of anti-drug antibodies and biomarkers in these Fabry patients provided us with important information on their pathological condition during ERT.
On the problem of the dynamical reactions of a rolling wheelset to real track irregularities
Authors: True Hans , Christiansen Lasse Engbo , Plesner Andreas Lindhardt , Ammitzbøll Andreas Lønstrup , Dahl Bjørn Jerram 
Published: October 2022

AbstractWe investigate numerically the dynamical reactions of a moving wheelset model to real measured track irregularities. The background is to examine whether the dynamics are suitable as the input to the inverse problem: determine the true track geometry from measured wheelset dynamical reactions. It is known that the method works well for the vertical position of the rails but the computed lateral position is often flawed. We find that the lateral motion of the wheelset often may differ from the track geometry. The cases are investigated closely but the reasons remain unknown. While the wheelset dynamics reflect the larger (> 4–6 mm) aperiodic track disturbances and single large disturbances quite well, this does not seem to be the case for general smaller or periodic track irregularities or sections behind single large disturbances. The resulting dynamics of a wheelset to lateral track irregularities are in general not sufficiently accurate to be used as the basis for a description of the track irregularities.
Electron beam powder bed fusion manufacturing of a Ti-5Al-5Mo-5V-3Cr alloy: a microstructure and mechanical properties’ correlation study
Authors: Hendl Julius , Marquardt Axel , Leyens Christoph 
Published: October 2022

AbstractElectron beam powder bed fusion (EB-PBF) is a powder-bed fusion additive manufacturing process, which is suitable for fabricating high-performance parts for a wide range of industrial applications, such as medical and aerospace. Due to its deep curing capabilities, the metastable β-alloy Ti-5Al-5Mo-5V-3Cr (Ti-5553) is currently mostly used in the landing gear of airplanes. However, its great mechanical properties make it also attractive for small, complex, and load-bearing components. In this study, nine melting parameter sets, combining different scanning speeds and beam currents, were used in the EB-PBF ARCAM A2X system. Furthermore, the correlation between the microstructure and the mechanical properties was investigated and analyzed by applying µ-focus computer tomography and microscopic methods (optical, SEM/EDS). A significant influence of the different melting parameters on the microstructure as well as on the mechanical performance was found. In a subsequent step, three melting parameters were selected and the specimens were heat-treated (BASCA, STA) for further investigation. The experimental results of this work indicate that Ti-5553 parts can be manufactured successfully with high quality (ρ > 99.60%), and post-processing heat-treatments can be used to modify the microstructure in such a way that the parts are suitable for a large variety of possible applications.
Goal-based outcomes of hospitalisation of older adults are predicted by gender, confidence, quality of life and type of goals
Authors: van der Kluit Maria Johanna , Tent Sanne , Dijkstra Geke J. , de Rooij Sophia E. 
Published: October 2022

Abstract
Purpose
Although patient-reported outcome measures (PROMs) might reflect relevant outcomes from patient perspective, they do not always reflect what the individual patient finds important. Our objectives were to assess which PROM was best suited to evaluate patient-relevant outcomes of hospitalisation and to assess which factors predicted this PROM.

Methods
A longitudinal study was conducted among hospitalised older patients. Three PROMs were compared with the anchor question ‘How much have you benefited from the admission?’: a general quality of life measure: EQ-5D; a measure of daily functioning: Katz-15 and a goal-based measure: achievement of self-defined goals. Predictors were examined using logistic regression analyses.

Results
We had 185 cases with baseline and follow-up. Accomplishment of self-defined goals showed a large correlation with the anchor question, whereas EQ-5D and Katz-15 showed no significant correlations. The final regression model had four predictors: being man, having higher confidence in goal achievement and good/excellent quality of life increased the odds for goal accomplishment, while having goals in the category alleviating complaints reduced the odds.

Conclusion
Accomplishment of individual goals represented the benefit experienced by participants best. Subjective indicators of health and functioning are better predictors of goal accomplishment than objective ones. According to participant experience, the hospital appeared successful in managing disease-specific problems, but less successful in ameliorating complaints. Medical decision-making should not only be based on medical indicators, but the input of the patient is at least as important. Quality of life, goals and confidence should be discussed. More attention is needed for symptom experience.
Exploring New Computational Strategies for Managing Maintenance Activities of Airport Pavement Systems
Authors: Ragusa Eliana , Costa Antonio , Di Graziano Alessandro 
Published: October 2022

AbstractIn this paper, the optimization of the maintenance management problem regarding airport pavements is addressed by developing a series of fast computational procedures whose rationales pursue both practical and economical objectives. Particularly, the study involves the design of five new heuristic algorithms replicating different management strategies that can be undertaken by the airport managers in a certain time horizon for reducing the pavement maintenance costs while considering the impact on the service level of the airport. Each algorithm works on the basis of a preliminary computational framework that has a twofold scope: (i) selecting the pavement portions to be maintained during the provided time horizon. (ii) using a K-means method based on three well-known performance indicators, which, namely, are Residual Life (RL), International Roughness Index (IRI) and Pavement Condition Index (PCI), to group the selected portions into homogenous clusters named work-zones. To evaluate the effectiveness and the efficiency of the proposed optimization algorithms in coping with the maintenance programming problem under investigation, an extended design of experiments based on international airport regulations has been arranged. The obtained numerical results revealed that no single strategy can be selected as the most performing in terms of cost and quality conditions of the pavements. To make robust the numerical results, a sensitivity analysis is conducted to evaluate the influence of the total cost of maintenance on runway length and number of sections. However, the results obtained in this study provide a series of managerial implications, further expanding the research contribution.
Comparison of three modelling frameworks for aquatic ecosystems: practical aspects and applicability
Authors: Patonai Katalin , Fábián Virág Adrienn 
Published: October 2022

AbstractFreshwater ecosystems are under multiple stressors and it is crucial to find methods to better describe, manage, and sustain aquatic ecosystems. Ecosystem modelling has become an important tool in integrating trophic relationships into food webs, assessing important nodes using network analysis, and making predictions via simulations. Fortunately, several modelling techniques exist, but the question is which approach is relevant and applicable when? In this study, we compare three modelling frameworks (Ecopath, Loop Analysis in R, STELLA software) using a case study of a small aquatic network (8 nodes). The choice of framework depends on the research question and data availability. We approach this topic from a methodological aspect by describing the data requirements and by comparing the applicability and limitations of each modelling approach. Each modelling framework has its specific focus, but some functionalities and outcomes can be compared. The predictions of Loop Analysis as compared to Ecopath’s Mixed Trophic Impact plot are in good agreement at the top and bottom trophic levels, but the middle trophic levels are less similar. This suggests that further comparisons are needed of networks of varying resolution and size. Generally, when data are limiting, Loop Analysis can provide qualitative predictions, while the other two methods provide quantitative results, yet rely on more data.
Comparison of computational algorithms for simulating an electrospray plume with a n-body approach
Authors: Hampl Sebastian K. , Waggoner Marshall T. , Gallud Cidoncha Ximo , Petro Elaine M. , Lozano Paulo C. 
Published: October 2022

AbstractIn order to better evaluate the trade-offs between different simulation options for an electrospray thruster plume, we have developed a multi-scale n-body code to compute the evolution of a single emitter electrospray plume in the pure ionic regime. The electrostatic force computations in the simulation are captured through the use of three different computational algorithms with various degrees of approximation. The results of the simulations for a simple test case are compared in terms of computational speed and accuracy. The test case utilizes a single operating point (323nA) for a stable meniscus solution for the ionic liquid EMI-BF4 firing in the positive pure ion mode. Complex species and probabilistic fragmentation processes are neglected. An overview is provided of the trade-off between accuracy and computational speed for the three algorithms in the context of simulating the electrostatic interactions between particles. For a large number of particles, the faster algorithms show a significant reduction in computational time while maintaining a high level of accuracy with a proper choice of tuning parameters.
SOPHIE: Generative Neural Networks Separate Common and Specific Transcriptional Responses
Authors: Lee Alexandra J. , Mould Dallas L. , Crawford Jake , Hu Dongbo , Powers Rani K. , Doing Georgia , Costello James C. , Hogan Deborah A. , Greene Casey S. 
Published: October 2022

Abstract
Genome-wide transcriptome profiling identifies genes that are prone to differential expression (DE) across contexts, as well as genes with changes specific to the experimental manipulation. Distinguishing genes that are specifically changed in a context of interest from common differentially expressed genes (DEGs) allows more efficient prediction of which genes are specific to a given biological process under scrutiny. Currently, common DEGs or pathways can only be identified through the laborious manual curation of experiments, an inordinately time-consuming endeavor. Here we pioneer an approach, Specific cOntext Pattern Highlighting In Expression data (SOPHIE), for distinguishing between common and specific transcriptional patterns using a generative neural network to create a background set of experiments from which a null distribution of gene and pathway changes can be generated. We apply SOPHIE to diverse datasets including those from human, human cancer, and bacterial pathogen Pseudomonas aeruginosa. SOPHIE identifies common DEGs in concordance with previously described, manually and systematically determined common DEGs. Further molecular validation indicates that SOPHIE detects highly specific but low-magnitude biologically relevant transcriptional changes. SOPHIE’s measure of specificity can complement log2 fold change values generated from traditional DE analyses. For example, by filtering the set of DEGs, one can identify genes that are specifically relevant to the experimental condition of interest. Consequently, these results can inform future research directions. All scripts used in these analyses are available at https://github.com/greenelab/generic-expression-patterns. Users can access https://github.com/greenelab/sophie to run SOPHIE on their own data.
Bay salt in seventeenth-century meat preservation: how ethnomicrobiology and experimental archaeology help us understand historical tastes
Authors: Tsai Grace E. , Anderson Robin C. , Kotzur Jackie , Davila Erika , McQuitty John , Nelson Emelie 
Published: October 2022

Abstract‘Sea salt is made by boiling and evaporating sea water over the fire. Bay salt, by evaporating sea water, in pits clayed on the inside, by the heat of the sun. Basket salt is made by boiling away the water of salt springs over the fire. Rock salt is dug out of the ground’, wrote Charlotte Mason in The Lady's Assistant (1775), one of the most comprehensive eighteenth-century cookbooks. Although there were at least four variations of salt before the pre-industrial era, several historical recipes specified the use of bay salt (solar salt) for meat preservation, elevating its cultural status and implying that early modern actors had a refined understanding of salts, their tastes and their applications. This study uses scientific analysis to determine whether there is a biological or chemical basis for the superior reputation of bay salt for curing. Laboratory data suggest that bay salt contains microbes that produce nitrate and nitrite, which give the meat a more favourable taste and pleasant aesthetic. The authors thus demonstrate that combining insights from experimental archaeology with textual analysis of historical sources gives us a deeper understanding of historical uses of taste as an epistemic tool.
Hope Amid Crisis: Normative Ambiguity, the Middle Class, and Investment Fraud in 2000s Venezuela
Authors: Leslie Camilo Arturo 
Published: October 2022

ABSTRACTStudies of futurity typically privilege licit economies and assume that the lines between licit and illicit institutions are largely clear to the actors involved. But what happens to those actors, and their grip on the future, when such lines blur? This article explores the epistemic crossroads of futurity and legality by focusing on ambiguity. From 1986 to 2009, the Stanford Financial Group reaped billions of dollars selling fraudulent investment products to thousands of Venezuelans. During this span, Venezuelans suffered successive governments’ shambolic currency schemes, bureaucratic dysfunction, judicial corruption, political upheaval, and worsening street crime. As crises became routinized, middle-class Venezuelans faced “normative ambiguity,” a loss of familiar legal and moral certainties, undercutting their sense of futurity. Drawing on 54 interviews with defrauded investors and others linked to the case, this article shows how such ambiguity left investors vulnerable to a fraud that promised to restore that threatened futurity.
Explaining women's political underrepresentation in democracies with high levels of corruption
Authors: Erlich Aaron , Beauvais Edana 
Published: October 2022

AbstractMany democracies with high levels of corruption are also characterized by low levels of women's political representation. Do women candidates in democracies with high levels of corruption face overt voter discrimination? Do gender dynamics that are unique to highly corrupt, democratic contexts influence citizens’ willingness to vote for women? We answer these questions using two separate sets of experiments conducted in Ukraine: two vignette experiments and a conjoint analysis. In line with existing cross-sectional research on Ukraine, our experiments reveal little evidence of direct voter bias against women candidates. Our conjoint analysis also offers novel insights into the preferences of Ukrainian voters, showing that both men and women voters place a great deal of value in anti-corruption platforms, but voters are just as likely to support women and men candidates who say they will fight corruption. Our analysis suggests that women's political underrepresentation in highly corrupt contexts is driven more by barriers that prevent women from winning party nominations and running for office in the first place, rather than overt discrimination at the polls.
A predicted developmental and evolutionary morphospace for grapevine leaves
Authors: Chitwood Daniel H. , Mullins Joey 
Published: October 2022

Abstract
Using conventional statistical approaches there exist powerful methods to classify shapes. Embedded in morphospaces is information that allows us to visualise theoretical leaves. These unmeasured leaves are never considered nor how the negative morphospace can inform us about the forces responsible for shaping leaf morphology. Here, we model leaf shape using an allometric indicator of leaf size, the ratio of vein to blade areas. The borders of the observable morphospace are restricted by constraints and define an orthogonal grid of developmental and evolutionary effects which can predict the shapes of possible grapevine leaves. Leaves in the genus Vitis are found to fully occupy morphospace available to them. From this morphospace, we predict the developmental and evolutionary shapes of grapevine leaves that are not only possible, but exist, and argue that rather than explaining leaf shape in terms of discrete nodes or species, that a continuous model is more appropriate.
Petrous internal carotid artery aneurysm rupture induced by Eustachian tube catheterisation: case report
Authors: Hyakusoku H , Tsuchiya Y , Matsushita Y , Nakayama M 
Published: October 2022

AbstractBackgroundPetrous internal carotid artery aneurysms are very rare vascular lesions, which may present with otalgia and life-threatening massive otorrhoea.Case reportAn 84-year-old woman presented at a local otolaryngology clinic with progressive otalgia due to an acute exacerbation of chronic otitis media. She was referred with left-sided massive otorrhoea following Eustachian tube catheterisation. She suffered another massive otorrhoea with epistaxis during left-sided ear cleaning at a clinic visit. Contrast-enhanced computed tomography and computed tomography angiography revealed a left-sided aneurysm and adjacent stenosis at the left internal carotid artery. Coil embolisation of the petrous internal carotid artery aneurysm was performed with percutaneous transluminal angioplasty followed by dilatation of the stenosis.ConclusionComputed tomography angiography should be performed immediately when a patient reports massive otorrhoea. Endovascular occlusion is a treatment option as it avoids complications of open surgical ligation procedures.
Roe v. Wade and the Predatory State Interest in Protecting Future Cannon Fodder
Authors: Häyry Matti 
Published: October 2022

AbstractThe reversal of Roe v. Wade by the U.S. Supreme Court allowed the states to regulate terminations of pregnancy more autonomously than during 1973–2022. Those who think that women should be legally entitled to abortions at their own request are suggesting that annulling the reversal could be an option. This would mean continued reliance on the interpretation of privacy that Roe v. Wade stood on. The interpretation does not have the moral support that its supporters think. This can be shown by recalling the shortcomings of Judith Jarvis Thomson’s famous violinist example and its application to abortion laws. Philosophically better reasons for not restricting access to abortion can be found in a simple principle of fairness and in sensible theories on the value of human life. Whether or not philosophy has any use in the debate is another matter. Legal decisions to regulate terminations are probably based on pronatalist state interests, shared by the apparently disagreeing parties and immune to rational argumentation.