bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of major dietary patterns with the risk of obesity and metabolic syndrome in adults of Hoveizeh city
Authors: Ziba Bahar , Hosseini Seyed Ahmad , Cheraghian Bahman , Mansoori PhD Anahita 
Published: September 2022

Abstract
Introduction: Obesity is a multifactorial metabolic disorder, the development and progression of which can be caused by genetic, physiological, metabolic, socioeconomic and lifestyle factors (especially physical activity and diet). Therefore, considering the high prevalence of obesity and its complications, and taking into account that dietary patterns are different in different populations and geographical locations, the present study aims to identify and investigate the relationship between dietary patterns and Obesity diseases was conducted in the adult population of Hovizeh city. Method: 5821 participants (2076 obese group and 3745 not obese group) from Hoveizeh cohort study for this case control study were chosen. Data related to dietary, demographic, anthropometric and physical activity information were previously obtained through a questionnaire. dietary patterns were identified using factor analysis. Then, logistic regression method was used to determine the relationship between major food patterns and obesity. results: In this study, four major food patterns were identified, including 1) vegetable and high-protein food pattern, 2) traditional, 3) sweets and snacks, and 4) good oils. Following these patterns had no significant relationship with obesity and anthropometric indicators Conclusion: There was no association between identified dietary patterns and obesity.
The Outcome of Nationwide Community Outreach Service for Child and Adolescent with Mental Disabilities and Psychiatric Disorders in Taiwan: A 6-year Follow-up Study
Authors: Hsieh Wen-Yang , Hsu Chao-Wei , Li Wen-Chi , Tsai Ching-Hong , Ou Tian-Sin , Chang Ching-Wen , Chen Cheng-Chung 
Published: September 2022

Abstract
Objective
To improve the quality of health care, the Ministry of Health and Welfare of Taiwan start to launch a project in June 2015, providing community outreach services and outpatient psychiatric treatment to schools, institutions for child and adolescent patients with mental disabilities. The main purpose of this study was to analyze the development of the project and intended to promote medical service quality for child and adolescent patients.
Methods
Service team members from eight medical centers and psychiatric hospitals in Taiwan, providing both outreach community services and outpatient psychiatric treatment. We collected the personal information and assessment scale scores of all patients from January 2016 to December 2021 (N = 432).
Results
The findings revealed significant improvement in the scores of C-GAS, PSP, CGI-S, and CGI-I (p < 0.001). The scores of the self-reported assessment scale ASEBA also showed significant improvement for internalizing problems, externalizing problems and total problems (p < 0.001). Most of the disabled children and adolescents have benefited greatly from this project, including presenting less disruptive behavior, fewer hospital readmissions, and more improved adaptation.
Discussion
This 6-year community-based follow-up treatment shows that the majority of disabled patients continue experiencing an improved condition after intervention.
Prostaglandin E2 receptor EP1 expression in vulvar cancer
Authors: Buchholz Anna , Vattai Aurelia , Fürst Sophie , Vilsmaier Theresa , Zehni Alaleh Zati , Steger Alexander , Kuhn Christina , Schmoeckel Elisa , Dannecker Christian , Mahner Sven , Jeschke Udo , Heidegger Helene H. 
Published: September 2022

Abstract
Purpose
In recent years incidence of vulvar cancer has been on the rise, whereas therapeutic options are still restricted. Therefor new prognosticators and therapeutic targets are essential. Chronic inflammation plays an important role in carcinogenesis and COX-2, its product prostaglandin E2 and its receptors EP1–4 are known to be important mediators in cancer initiation and progression.
Methods
EP1 expression in vulvar cancer specimens (n = 129) was investigated via immunohistochemistry and evaluated using the well-established immunoreactive score (IRS). Subsequently, the values were correlated with clinicopathological parameters.
Results
Our analysis did not reveal EP1 expression as a negative prognostic factor in overall and disease-free survival. However, in the subgroup of patients with lymph node metastasis, overall survival was significantly shorter in tumors with high EP1 expression. Moreover, EP1 expression correlated positively with good differentiation of the tumor, but not with p16 status or COX-2 expression.
Conclusions
This study shed first light on EP1 expression in vulvar carcinoma. EP1 expression correlated significantly with the grading of the tumor, suggesting that it influences cell differentiation. Further research on EP1 signaling may lead to a deeper understanding of the molecular mechanisms of carcinogenesis.
Selection of Preferable Eco-Tourism Destinations using Analytical Hierarchy Process in Purulia District, West Bengal (India)
Authors: DOLUI SANU , chakraborty sayani 
Published: September 2022

Abstract

Eco-tourism is a form of nature based ecologically sustainable tourism, getting popularized in recent years among tourists due to the adverse impact of conventional tourism. The conventional way of tourism severely impacted the environment, loss of habitat and destruction of nature and natural landscape, Pressurizing local resources, and the Loss of cultural uniqueness of the local community. Purulia district in West Bengal (India), with its diversified picturesque landscape such as lush green Forest, mesmerizing riverscape, lakes, waterfall, hills, and uniqueness in the local community's culture gives ample potentiality of eco-tourism development. The aim of this paper to Explore potentiality of Ecotourism in Purulia district, West Bengal, India using analytical hierarchy process (AHP) and geographical information system (GIS). Initially ecotourism inventory dataset was developed based on following criteria: Elevation, Slope, Proximity River area, Distance from Road, Distance from Settlement patches, Distance from Ecological sites, Distance from railway Track, Distance from existing Tourism sites using ARC-GIS 10.6.1 software. Later, the suitability map of eco-tourism development has been developed by applying Weighted Linear Combination (WLC) with combination of the criteria with their respective weights and categorized into five suitability classes as Highly Suitable (S1), Moderately Suitable (S2), suitable (S3) less Suitable (S4), and unsuitable (S5). Finally, After the identification of suitable zones, six alternatives eco-tourism destinations are identified. This proposed method may be helpful for the for local stakeholders and public administration in identifying potential ecotourism destination and planning for sustainable eco-tourism development.
Assessment of radiographic and prognostic characteristics of programmed death-ligand 1 expression in high- grade gliomas
Authors: Ohno Makoto , Kitano Shigehisa , Satomi Kaishi , Yoshida Akihiko , Miyakita Yasuji , Takahashi Masamichi , Yanagisawa Shunsuke , Tamura Yukie , Ichimura Koichi , Narita Yoshitaka 
Published: September 2022

Abstract
Purpose
Gliomas are characterized by immunosuppressive features. Programmed death-ligand 1 (PD-L1) is overexpressed and plays an important role in the immunosuppressive tumor microenvironments of gliomas. However, the radiographical and prognostic significance of PD-L1 expression remain unclear.
Methods
Using tissue microarrays, we evaluated PD-L1 expression and the presence of tumor-infiltrating CD4 + and CD8 + T cells and CD204 + macrophages using immunohistochemical analysis. Contrast enhancement area and fluid-attenuated inversion recovery (FLAIR) hyperintensity area were evaluated by two-dimensional analysis. Kaplan–Meier analysis was performed to evaluate the overall survival time in 44 patients with isocitrate dehydrogenase (IDH)-wildtype glioblastoma.
Results
We evaluated 71 patients with newly diagnosed high-grade gliomas who were treated between October 1998 and April 2012. PD-L1 expression was observed in 15 patients (21.1%). A significant association of PD-L1 expression with the CD4 + and CD8 + T cell densities, but not with CD204 + macrophage density, was observed (p = 0.025, p = 0.0098, and p = 0.19, respectively). The FLAIR-to-enhancement ratio was significantly higher in PD-L1 + tumors than in PD-L1- tumors (p = 0.0037). PD-L1 expression did not show a significant association with the median survival time (PD-L1 + vs. PD-L1-: 19.2 vs. 14.9 months; p = 0.39).
Conclusion
PD-L1 expression was associated with CD4 + and CD8 + T cell infiltration, indicating a significant interplay between PD-L1 and immune cells. The positive correlation of PD-L1 expression with an increased FLAIR-to-enhancement ratio suggested that radiographical characteristics could reflect the immunological status. Our results did not support the prognostic impact of PD-L1 in patients with IDH-wildtype glioblastomas.
From Digital to Quantum Epidemiology: The Quantum Data Lake concept for Big Data related to viral infectious diseases
Authors: Kolesnichenko Olga , Nakonechniy Igor 
Published: September 2022

Abstract

The study is dedicated to the development of quantum epidemiology which is the expected next stage in epidemiology transformation as new quantum technologies have emerged. At the present time, epidemiology is entering the digital era and undergoes a paradigm shift from data-driven to value-driven strategy. The epidemiology data are characterized by uncertainty, multidimensionality, and disconnection, which drive to prefer the quantum approach for data exposition, creation of value, and modeling. The Quantum Data Lake concept is proposed. The data about DNA viruses with symptoms and diseases are shown as example of epidemiology data complexity. The Quantum Data Lake concept consists of several layers and quantum tools, including PT-symmetry and non-Hermiticity as intuitive modeling tools. PT-symmetry breaking is able to detect the hidden shift in the information which is permanently updated in the Data Lake. The duality of PT-symmetry breaking can be compared with the estimation of the best and worst scenarios simultaneously. In contrast to the widely discussed advantages of quantum computing such as high-speed performance and very large parallel scale, the proposed approach emphasizes the fundamental uniqueness of quantum theory for modeling. The study highlights the necessity to investigate the native processes of viruses’ interaction with the human population by relying on quantum theory’s natural properties. Implementation of quantum logic and reliance on a quantum theory is the fundamental difference between the current digital epidemiology and future quantum epidemiology.
What has drugs use and other factors got to do with suicidal behaviour among in-school students in Bolivia? Analysis of a national survey
Authors: Appiah Francis , Dorgbetor Cyprian Issahaku , Aidoo Antoinette Ama , Boakye Kingsley , Ayerakwah Patience Ansomah 
Published: September 2022

Abstract
Background
About 23.5% and 13.2% of female and male students respectively ever attempted suicide in 2017 in Bolivia. The annual prevalence of drugs usage such as marijuana has increased in Bolivia. Studies have highlighted that substance abuse correlates with suicidal behaviours. The association between drug use and suicidal behaviour is less explored in Bolivia. This study aimed at investigating the association between drug use and suicidal behaviour among in-school students in Bolivia.
Methods
The study relied on a dataset obtained from the 2018 Bolivian Global School-Based Student Health Survey (BGSHS). The survey followed a two-stage cluster sampling procedure and in all, a total of 7,931 in-school students were interviewed yielding a response rate of 79%. However, this study was restricted to 4,684 in-school students who have complete data about variables of interest analysed in the study. Suicidal behaviour and drug use were the outcome variable and main explanatory variables, respectively. At 95% confidence interval, two models were built using logistic regression. Model I assessed the association between the outcome variable and the main explanatory variable and Model II controlled the influence of covariates on suicidal behaviour. The results for Model II were presented in adjusted Odds Ratio (aOR).
Results
Generally, 17% (weighted N = 813; CI = 0.16–0.18) of students indulged in suicidal behaviour. Inferentially, those who ever used drugs were over two-fold likelihood to indulge in suicidal behaviour compared with those who were not on drugs in the unadjusted model [OR = 2.59, CI = 2.08–3.21] and this persisted in the adjusted model [aOR = 1.52, CI = 1.07–2.17]. Females [aOR = 3.02, CI = 2.51–3.63], those whoever had difficulties sleeping [aOR = 2.23, CI = 1.70–2.89], ever used alcohol [aOR = 1.57, CI = 1.30–1.90] and whose parents go through their things [aOR = 1.48, CI = 1.24–1.76] had higher odds of suicidal behaviour. The likelihood of suicidal behaviour reduced among those whose parents understand their problem [aOR = 0.55, CI = 0.45–0.68] and know their free time [aOR = 0.62, CI = 0.50–0.78] or were not bullied [aOR = 0.57, CI = 0.47–0.68].
Conclusion
The study revealed that drugs use was associated with suicidal behaviour among in-school students in Bolivia. Other findings were that alcoholism, poor parental concern, bullying and having a history of physical attacks were associated with suicidal behaviour. The Government of Bolivia through its law enforcement agencies should strengthen their strategies targeted at controlling drug usage among in-school students. Parents should extend emotional support and care to in-school students so that their wards can properly cope and manage their emotional challenges appropriately.
Impact of gamma (γ) irradiation on morphology, biochemical and antioxidant activity of green gram (Vigna radiata (L.) R. Wilczek)
Authors: D Arulbalachandran 
Published: September 2022

Abstract

One of the key sources of genetic variability that is ultimately used in the plant development program is mutations. In order to improve crops, mutagens are used, and mutants have been obtained from induced mutations. Gamma irradiation is one of the mutagens that helps to quantify the frequency and patterns of alterations in particular plants. In this present 26 study, the gamma irradiation effect was investigated by germination study and physiological characteristics of green gram. Seeds were exposed to a gamma source (CO60) at doses ranging from 100, 200, 300, 400, 500, 600, 700, and 800, with a non-irradiated sample as a control. Our results show that the germination percentages as well as morphological parameters of seedlings (root length, shoot length, fresh weight, and dry weight) decreased with increasing irradiation doses. These findings were confirmed by ESR spectroscopy with the g-factor at 2.000 ± 0.005. The photosynthetic pigments such as chlorophyll a and b were decreased in irradiated seedlings compared to control, where carotenoid content was increased. Biochemical content such as protein, amino acid, reducing sugar, starch and proline content was increased with increasing doses and it was concerned with various stretching bands analyzed by FTIR analysis. MDA content was increased with increasing doses by the production of free radicals. Antioxidant enzymes such as catalase and peroxidase were increased in irradiated seedlings, which act as free radical scavengers. These results suggested that there had been up to 600 Gy significant changes in morphology, photosynthetic pigment, biochemistry, and antioxidant analyses.
Crime Rate Prediction in Different Environment Using Hybrid Classifier
Authors: S. Santhosh , N. Sugitha 
Published: September 2022

Abstract
In the era of globalization, crime is a subject that is feared and dreaded by the public all around the world. Crime is an integral part of risks that we are facing it in every day. Nowadays, there have been many criminal cases reported by the mass media, such as theft, rape and sex offenses, robbery, murder and kidnappings. High crime rate makes people feel insecure, thus become one of the major problems in society. In the recent era of increasing volume crimes, crime prevention is now one of the most important global issues, along with the great concern of strengthening public security. The crime prediction method is to predict the crime rates that help police officer to prevent the crime rates in effective way. From that, we propose a new prediction method based on hybrid classifier. The proposed methodology consist of four stages namely, data collection, pre-processing, feature selection and prediction. Initially, the data are collected from internet. Then, in pre-processing stage, redundant and missing values are removed. After that, in feature selection process, important features are selected. Finally, the selected features are given to the hybrid classifier. Hybrid classifier is a combination of support vector machine (SVM) and artificial neural network (ANN). Finally, based on the score value, the crimes are predicted. The performance of proposed methodology is analysed in terms of different metrics. The proposed method implemented in JAVA. From the result, this method efficiently retrieves the features of the crime with a high accuracy of 94.028% compared to other existing methods.
Overlap syndrome: association of gastroesophageal reflux disease with dyspepsia syndrome in schoolchildren
Authors: Polivanova T. V. , Vshivkov V. A. 
Published: September 2022

The combination of gastroesophageal reflux disease with dyspepsia syndrome in a particular patient is designated as overlap syndrome, the problem of which is widely discussed.Purpose. To study the regional characteristics of the association of gastroesophageal reflux disease with dyspepsia syndrome in Siberian schoolchildren with gastrointestinal complaints.Materials and methods. Schoolchildren of Siberia 7–17 years old were examined: in Tyva (1535 children), Buryatia (790 children), and Evenkia (1369 children). Information about gastroenterological complaints was collected. By the method of random selection, children with gastroenterological complaints underwent esophagogastroduodenoscopy in Tyva, 283 children, in Buryatia, 110 children, and in Evenkia, 205 children. The studies were approved by the ethics committee and the consent of the patients and their parents was obtained.Results. In Siberian schoolchildren, the prevalence of GERD and DS overlap syndrome was 4.7%. In Tyva, the overlap of gastroesophageal reflux disease with dyspepsia syndrome in schoolchildren was found most often: 6.9%, which was significantly higher than in Buryatia (3.7%; p = 0.0016) and in Evenkia (2.8%; p = 0.0001). regional features have been established in the distribution of clinical variants of dyspepsia associated with gastroesophageal reflux disease in schoolchildren. So, in the children of Buryatia and Evenkia, the dominant association was gastroesophageal reflux disease with postprandial distress syndrome, in Tyva — with epigastric pain. Among endoscopically examined schoolchildren in the absence of erosive and ulcerative diseases, similar associative relationships between gastroesophageal reflux disease with dyspepsia syndrome and its clinical variants were determined.Conclusion. Regional differences were established, both in the prevalence of overlap syndrome and the severity of the association of gastroesophageal reflux disease with variants of the clinical course of dyspepsia syndrome. It is not unlikely that overlapping disorders are united by a single leading pathomechanism in their formation.
Different Modalities Used in the Art of Managing Tracheobronchial Foreign Bodies
Authors: Hemead Hanan M. , Ramadan Abdelmaguid , Gaafar Alaa H. , Nossier Ayman , Abdelaziz Ahmed 
Published: September 2022

Introduction:
Foreign body aspiration is a commonly encountered and challenging emergency. Foreign body aspiration causes significant morbidity and mortality in the paediatric population. In adults, it is usually encountered in patients with impaired consciousness and in young females using pins to secure their veils. We aimed to analyse the incidence, type and site of foreign body, radiological presentation, complications and different modalities used in managing tracheobronchial foreign bodies (FBs).

Methods:
A prospective single centre cross-sectional study between December 2010 and December 2011 in the Department of Cardiothoracic Surgery at the University of Alexandria, Egypt.

Results:
Seventy-eight patients were included. The age of the patients ranged between 1.3 and 32 years, with a mean of 13.37± 7.67 years. Inorganic FBs were the most common aspirated FBs (66 patients, 84.62%). FBs were more frequently located in the left versus the right bronchial tree (44.9% vs. 43.6%). Rigid bronchoscopic extraction of foreign bodies was the most common modality of extraction and was seen in 60 patients (76.9%), followed by thoracotomy and postural drainage in eight patients each (10.3%). Complications were observed in 12 patients (15.4%). Most of the patients who presented with pin aspiration were teenagers (> 10 – 20 years) and adults (> 20 years). At the same time, nut aspiration was common in children below 10 years.

Conclusion:
The location of FBs in the tracheobronchial tree depends on the patient's age and physical position at the time of aspiration. Rigid bronchoscopy offers better manipulations inside a secured airway and is the preferred method for foreign body removal. If failed, then surgical extraction should be done as soon as possible.