bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scanning accuracy with splinted and unsplinted implant scan bodies for the edentulous arch at implant level: an in vitro study
Authors: GARBACEA ANTOANELA , Alqahtani Ali F , Goodacre Brian , Alhelal Abdulaziz , Lozada Jaime , Kattadiyil Mathew T 
Published: July 2022

Accuracy of completely edentulous arch scanning with implant scan bodies has not been completely validated for intraoral scanners. For desktop laboratory scanners validations were found in the literature. The aim of this in vitro study was to compare the dimensional accuracy of scanning with splinted and unsplinted scan bodies on a completely edentulous maxillary arch with 6 implants. A maxillary edentulous master cast with 6 implants was used as control for all implant level impressions. 6 implants were digitally planned and placed at different angulation of 0, 0 17° and 30°. A contact coordinate measuring machine (CMM) was used to generate baseline linear measurements of the master cast. Four test groups included: 2 intraoral scanners Trios (3shape, Copenhagen, Denmark) and True Definition (3M ESPE, St Paul, MN), one industrial scanner Atos (Core optical 3D scanner) and one conventional impression group scanned with laboratory scanner Dental Wings 7 Series. Each scan recording was made with splinted and unsplinted scan bodies. Digital datasets of all measurements were compared with the CMM baseline values using PolyWorks® InnovMetric Software in order to assess the linear and angular deviations and determine the accuracy of complete arch digital impression. Factorial ANOVA showed significant effect with splinting, scanner type, inter-implant distance and implant angulation for linear deviations. Splinted scan bodies revealed elevated linear and angular deviation values for all scanners with significantly highest deviations for True Definition scanner. Significant correlation was found between inter-implant distance and linear deviation (r =0.45, P =&lt;0.001) with increased linear deviations among all scanners, regardless of splinting. ( P &lt;0.05). Significant effect on accuracy was seen for angular deviation with splinting, scanner type and implant angulation; significant difference was found between 0° and 30° implant angulation ( P =0.035) with more deviation with 30° implant angulation. The accuracy of the complete arch implant digital impression using splinted scan bodies was significantly reduced for measurements that crossed the arch midline. The digital impression technique using a broad splint design to connect scan bodies was not found to improve the scan accuracy for intraoral scanners.
Antimicrobianos y periodonto
Authors: Alzamora De La Rosa Leslie Esther , Julio Narváez Luis Carlos , Julio Alzamora Luis David de Jesús 
Published: July 2022

Resumen: las infecciones odontogénicas (IO) están relacionadas con compromiso de la pulpa dental y afección del periodonto, son polimicrobianas pero predominan los anaerobios estrictos. Además del drenaje o manejo quirúrgico, se utilizan antimicrobianos que acortan el tiempo de resolución y favorecen desenlaces predominantemente en términos de reducción de la profundidad de sondaje (PD) y ganancia de nivel de inserción. Los antimicrobianos más usados son los betalactámicos combinados con inhibidor de betalactamasa, el nitroimidazol, metronidazol, la azitromicina, entre los macrólidos, la lincosaminas, principalmente la clindamicina y las quinolonas con mayor éxito la moxifloxacina. Se han utilizado diversos regímenes de estos antimicrobianos para determinar la no inferioridad en la mayoría, pero se han encontrado ventajas específicas con el uso de algunos como el menor tiempo de terapia, la mayor efectividad en el caso de la aparición de resistencia bacteriana y menores efectos secundarios.
Pelatihan Pembukuan Keuangan untuk Pengelola Lembaga PAUD
Authors: Anisa Nur , Furqorina Rizka , Gonadi Leni , Wulandari Retno Tri 
Published: July 2022

PAUD managers in Batu City are still experiencing difficulties in administering financial bookkeeping. This has an impact on the management of PAUD institutions to administer financial books and produce financial reports that do not meet the education financing standards. This training aims to increase the knowledge and skills of PAUD managers in Batu City regarding the process of carrying out financial bookkeeping for early childhood education institutions. The methods used in the training included lectures, questions and answers to deliver basic concept material in the books of PAUD institutions; and 2) Practice and assistance in filling out administrative books needed in financial accounting. As a result of this community service activity, 80 percentage of PAUD managers understand the material and can manage the financial accounting of early childhood education institutions. Pengelola lembaga PAUD di Kota Batu masih mengalami kesulitan dalam melakukan administrasi pembukuan keuangan. Hal tersebut berdampak pada pengelolaan lembaga PAUD untuk melakukan administrasi pembukuan keuangan dan menghasilkan laporan keuangan yang tidak memenuhi Standar Pembiayaan Pendidikan. Pelatihan ini bertujuan untuk meningkatnya wawasan dan keterampilan pengelola PAUD di Kota Batu tentang proses melaksanakan pembukuan keuangan lembaga pendidikan anak usia dini. Metode yang digunakan dalam pelatihan meliputi: 1) ceramah dan tanya jawab untuk menyampaikan materi konsep dasar pembukuan lembaga PAUD; dan 2) Praktik dan pendampingan pengisian buku administrasi yang diperlukan dalam pembukuan keuangan. Hasil dari kegiatan pengabdian kepada masyarakat ini yaitu 80 persen pengelola PAUD memahami tentang materi dan dapat mengelola pembukuan keuangan lembaga pendidikan anak usia dini.
Interaction of the Anticancer Drug Abiraterone with dsDNA
Authors: Pronina V.V. , Agafonova L.E. , Masamrekh R.A. , Kuzikov A.V. , Shumyantseva V.V. 
Published: July 2022

The electroanalytical characteristics of double-stranded DNA (dsDNA) and the complex of dsDNA and the antitumor drug abiraterone acetate (AA) were studied by differential pulse voltammetry. The effect of abiraterone acetate on dsDNA was shown, which was registered by alteration the intensity of electrochemical oxidation of purine heterocyclic bases guanine and adenine using screen printed electrodes modified with functionalized carbon nanotubes. The binding constants (Kb) of the [dsDNA-AA] complex for guanine and adenine were 1.63×104 M-1 and 1.93×104 M-1, respectively. The electrochemical coefficients of the toxic effect were calculated as the ratio of the intensity of the electrochemical oxidation signals of guanine and adenine, in the presence of abiraterone acetate to the intensity of the electrooxidation signals of these nucleobases without drug (%). At concentrations of abiraterone acetate exceeding 60 μM, a decrease in the currents of electrochemical oxidation of guanine and adenine by 50% or more is recorded. Based on the analysis of electrochemical parameters and values ​​of binding constants, an assumption was made about the mechanism of interaction of abiraterone acetate with DNA, mainly due to the formation of hydrogen bonds with the minor groove. An electrochemical DNA biosensor was first used to study the mechanism of interaction of the anticancer drug abiraterone acetate with dsDNA.
MIDWIFERY CARE OF DELIVERY WITH CHRONIC HYPERTENSION SUPERIMPOSED PREECLAMPSIA AND UTERINE MYOMA (CERVICAL)
Authors: Wittiarika Ivon Diah , Faustina Gitta Arinda , Zukhrufatin Zukhrufatin 
Published: July 2022

Background: the most common causes of maternal death in Indonesia are hypertension/pre-eclampsia/eclampsia, bleeding, and infection. Hypertension in pregnancy ranks first as the cause of death in Indonesia at 33% (SRS Litbangkes, 2016). Cervical fibroids can cause complications in both pregnancy and childbirth. The purpose of this case report is to study midwifery care in complex cases. Case report: A 41-year-old woman, second pregnant, 36-37 week’s gestation, primipaternity, secondary primitua with chronic hypertension and uterine myoma (cervical) was referred to the hospital for delivery. Management focuses on support for the mother, involving the family, fulfill the needs of the mother, collaboration with the doctor conducting informed consent regarding the diagnosis, providing counseling and health education on tubectomy contraception, and accompanying the mother until the time of surgery. The mother's response is good, and optimistic about her condition and the baby. Conclusion: midwives in providing midwifery care in cases of delivery with chronic hypertension, superimposed preeclampsia and uterine myoma at an advanced health facility (Type A Hospital). Midwifery care is provided both independently and in collaboration with other professions. Delivery was carried out by caesarean section in accordance with the indications with the output of the mother and baby being healthy. Early detection, recognition of signs and symptoms, diagnosis, referral process and comprehensive management are carried out appropriately.
WOMEN'S LIVES AFTER BEING DIAGNOSED WITH CERVICAL CANCER
Authors: Kulsum Ummu , Budiono Dwi Izzati , Kurniawati Eighty Mardiyan 
Published: July 2022

AbstractBackground: Cancer is the second leading cause of death worldwide after cardiovascular disease. Apart from difficulties in treatment, poor prognosis, and adverse side effects of treatment, cervical cancer also presents psychological challenges for patients. The experience of being diagnosed with cervical cancer is a dramatic event for a woman and causes stress for patient and family For this reason, the exploration of how women with cervical cancer interpret their experiences was deemed important to be investigated in-depth. . Method: This study used a qualitative research design with a phenomenological approach. Data collected by in-depth interviews with 7 participants. Data analysis techniques used are: verbatim, coding, categorization, composing thematic context and data interpretation. Results: This study revealed that the enforcement of cervical cancer diagnosis is always accompanied by psychological challenges, both for patients and their families. After being diagnosed with cervical cancer, participants experienced various changes in all dimensions of their lives, which included changes in daily activities, economic changes, sexual and spiritual activities. Conclusion: Cervical cancer affects and changes all aspects of women's lives and their families, therefore the care given to cervical cancer patients should be carried out holistically
Library local history audio tour: the specifics of creation
Authors: Verkhov A. I. 
Published: July 2022

The popularization of local history knowledge, based on the fund of materials about the native land that is being formed by local libraries, includes the use of new information and online technologies. The format of the street audio tour allows the library to get closer to the user, such a tour is «a historian in your pocket». The purpose of this text (based on the experience of creating street audio tours by the our department of local history) is to outline both the real obstacles in creating an audio tour and the underestimated resources of libraries.So, for example, when preparing an audio tour, the libraries' own information resources may be underestimated. But relying on the local history fund the library has every opportunity to create a high quality excursion product. Especially noteworthy resources are the collections of periodicals, city directories and phonebooks of past years, which allow checking the facts and raising the degree of reliability of the tour.At the same time, one should not overestimate the competencies required for creating an audio tour, including those related to writing texts and working with audio recordings. The advantage of a guide created by non-pros is the possibility of creating an almost intimate one-to-one story. At the same time, librarians undoubtedly need both methodological support and technical advice.
Training and retraining of the library staff in Tajikistan: status and development trends
Authors: Makhmudov G. B. 
Published: July 2022

Libraries are an important social institution, significantly influencing the development of econ­omy, science, education and culture. They play the main role in forming the information infrastructure.The development of librarianship largely depends on the level of material support, the introduction of new technologies, the renewal of collections, as well as on the training of personnel. In many cases, just the problems of education, the level of qualification of the library personnel are decisive for providing population with effective information and library service. The author presents the results of the analysis of the state of library and information education in Tajikistan. The main strategic aspects of the development of higher education in the country are elucidated, as well as the trends in training, advanced training and retraining of library personnel, the problems are indicated and possible ways to solve them are defined.
Inhibition of extracellular and intracellular survival of Mycobacterial strains by alkaloids extracted from Justicia adhatoda leaves.
Authors: Mishra Smita , Khatri Manisha , Mehra Varsha 
Published: July 2022

Abstract
Tuberculosis (TB) continues to be one of the world's leading causes of death by the infectious pathogen Mycobacterium tuberculosis, which infects one-third of the global population. The emergence of the COVID-19 pandemic made its spread rapid and the treatment task more daunting. With the havoc of infectious disease expansion, traditional medicines have triggered tremendous interest worldwide. However, less availability of scientific evidence still hinders its practical use. In the present study, we evaluated the potential of the traditional medicinal plant, Justicia adhatoda, which has been used to treat respiratory ailments since ancient times. We have successfully isolated and characterized several bioactive compounds viz- Vasicoline, Vasicolinone, Adhatodine, Adhavasine, Aniflorine, and Vasicinone from J. adhatoda plant leaves, including Vasicine as the principal compound, and showed their anti-tubercular activity on nutrient-starved Mycobacterium smegmatis and Mycobacterium bovis. The study also directs their in-vitro and ex-vivo antimycobacterial potential on THP1 macrophages with internalized Mycobacterium. Our study is one of its first kind, where we assessed the synergistic antimycobacterial effect of the isolated compounds with the first-line drug Isoniazid (INH). Their potential role in promoting phagolysosome fusion and apoptosis of M. bovis infected THP1 macrophages is further evaluated.
Analysis of the phase velocities of (Pure, Slow and Fast ) Alfvèn waves in the E region of the ionosphere for low latitudes
Authors: kurt kadri 
Published: July 2022

Abstract
In this paper, (pure, slow, and fast) Alfvèn waves for the accepted conditions in Northern-hemisphere at E-region of ionospheric plasma were calculated with low latitudes by using Eq. (20,25-26) and the real geometry of Earth’s magnetic field, at hours 12.00 LT for the 1990 year which sunspot is maximum. One of the most important results of this study is to show analytically that the “MHD modes= (pure, slow and fast) Alfvèn waves” depend not only on the angle between the wave propagation vector (k) and the magnetic field (B) but also on the declination (D=It is the angle value between the direction of the sun's rays and the equatorial plane) and magnetic dip angle (I=It is the angle between real north and magnetic north). From the results obtained, the behavior of the magnitudes of the squares of the phase velocities of all MHD modes is consistent with the behavior of the distribution of electron density with low geographic latitude, even if the magnetic field vector is both perpendicular and parallel to the propagation vector of the wave. In parallel, the phase velocities of the waves are greater in summer than in winter. It has been determined that the propagation velocities of the fast and slow MHD mode in the magnetic equatorial trough region at (q = I) are very small, the energy is almost non-existent, but if q = 90 + I, the energy increases with latitude and is approximately maximum at the low latitude limit. It can be said that the minimum points are between 0-10 oN latitudes where the wave energies are the smallest, and the maximum points are between 20-30 oN latitudes the wave energies are the biggest.
Isoflavones have a potential role to play in off-flavour scavenging, with Isoflavone synthase 2 (IFS2) as a key player determining isoflavone accumulation in soybean seeds
Authors: Kumar Sandeep , Banerjee Sagar , Kaur Amandeep , Sasi Minnu , Kumari Sweta , Sachdev Archana , Dahuja Anil 
Published: July 2022

Abstract
Soybean (Glycine max (L.) Merr) is a nutrient-rich crop with limited consumer acceptability because of the presence of off-flavour. Owing to the ubiquity of isoflavones in soybean, their inherent antioxidant potential, and inhibitory effect on lipoxygenase activity, their sensorial attribute in mitigating off-flavour is currently being envisaged. We estimated the content and composition of isoflavones in 17 soybean cultivars and established the correlation between isoflavone profile and lipid peroxidation, which was measured in terms of Thiobarbituric acid (TBA) number and carbonyl value. The results showed a significant negative correlation of these parameters with the total isoflavone content and genistein: daidzein ratio. Besides, expression analysis of a key gene involved in isoflavone biosynthesis, i.e., isoflavone synthase (IFS1 and IFS2) in contrasting soybean genotypes during seed development revealed a higher expression of both isoforms in Bragg (High isoflavone) as compared to PUSA 40 (Low isoflavone) at different stages of seed development accompanied by more isoflavone accumulation. The cloning and in silico analysis of IFS isoforms revealed a more significant interaction with other biosynthesis enzymes by the IFS2, indicating its more substantial role in isoflavone synthesis. IFS2 overexpression thus can be a valuable target to increase isoflavone biosynthesis, thereby scavenging off-flavour.
Association between problematic use of smartphones and mental health in the Middle East and North Africa (MENA) region: a systematic review
Authors: bouazza samira , Elkinany Soukaina , ABBOUYI Samira , RHAZI Karima El , ZARROUQ Btissame 
Published: July 2022

Abstract
Background
Smartphones have become essential components of daily life, and research into the harmful effects of problematic smartphone use (PSU) on mental health is expanding globally. Although several recent studies have addressed the relationship between PSU and mental health in the Middle East and North Africa (MENA) region, this issue has yet to be synthesized and critically evaluated.
Methods
To find quantitative observational studies on the relationship between PSU and mental health in the MENA region, we developed a search strategy based on a search equation and adapted it for four databases. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were followed during the selection process. This review included approximately 33 cross-sectional studies and one cohort study out of the 6423 studies identified. The only available language was English. All identified studies published until October 8th, 2021, were considered. A modified Newcastle-Ottawa scale was used to assess the quality of the included studies, as we were interested in three mental health outcomes: depression, anxiety, and stress.
Results
The studies enrolled 21696 people and had low to moderate methodological quality. The prevalence of PSU ranges from 4.3 percent to 97.8 percent. The time factor (average duration of use per day, frequency of use, consultation during the night), type of application used on the smartphone, and socio-demographic characteristics were the determinants of PSU (age, gender, marital status). Depression, anxiety, and stress were all strongly correlated with PSU, with a stronger relationship between PSU and depression (0.164 ≤ r ≤ 0.996) than between PSU and anxiety (0.12 ≤ r ≤ 0.562) or stress (0.14 ≤ r ≤ 0.508).
Conclusions
PSU is a real public health issue because it is linked to mental illnesses and social dysfunctions that are a wearisome burden on society. As a result, more epidemiological studies, particularly longitudinal ones that respect the quality of evidence, are needed in all MENA countries to better plan, and implement preventive measures to avoid devastating complications for individuals and societies.
Systematic review registration:
an a priori protocol is registered on PROSPERO under the number CRD42022266732.
Prenatal methamphetamine hydrochloride exposure leads to signal transduction alteration and cell death in the prefrontal cortex and amygdala of male and female rats’ offspring
Authors: Maghsoudi Nader , Zare Nayereh , Mirbehbahani Seyed Hamidreza , Khodagholi Fariba , Khakpour Shahrzad , Mansouri Zahra , Yekta Batool Ghorbani 
Published: July 2022

Abstract
Background
In the last decade, there has been a great increase in methamphetamine hydrochloride (METH) abuse by pregnant women that exposes fetus and human offspring to a wide variety of developmental impairments that may be the underlying causes of future psychosocial issues.
Objective
Herein we investigated whether prenatal METH exposure with different doses (2 and 5mg/kg) could influence neuronal cell death and antioxidant level in the different brain regions of adult male and female offspring.
Methods
Adult male and female Sprague–Dawley rats prenatally exposed to METH (2 or 5mg/kg) and/or saline was used in this study. At week 12 adult rats' offspring were decapitated to collect different brain region tissues including amygdala (AMY), anterior cingulate cortex (ACC), and prefrontal cortices (PFC). Western blot analysis was performed to evaluate the apoptosis and autophagy related markers, and enzymatic assay was used to measure the level of catalase and also reduced glutathione (GSH).
Results
Our results showed that METH exposure during pregnancy increased the level of apoptosis (BAX/Bcl-2 and Caspase-3) and autophagy(Beclin-1 and LC3II/LC3I) in the PFC and AMY area of both male and female offspring’s brain. Also, we found an elevation in the GSH content of all three mentioned brain areas and catalase activity of PFC in the offspring's brain.
Conclusion
Prenatally exposure to METH increased cell death at least partly via apoptosis and autophagy in AMY and PFC of male and female offspring’s brain, while the antioxidant system tried to protect cells in these regions.
Evolution of moist wound healing: Methods of autologous tissue regeneration
Authors: Yamamoto Kenji , Miwa Senri , Yamada Tomoyuki , Setozaki Shuji , Hamuro Mamoru , Kurokawa Shunji , Enomoto Sakae 
Published: July 2022

Abstract
Since the first report of an autologous tissue regeneration technique in 1962, hydrocolloids have been widely used for wound closure. However, complete closure of the wound may result in an infection, which is a major setback. Several dressing types have been unable to circumvent this issue and are not recommended in infected wounds. Wound infection is difficult to determine; in several countries, the wound is often covered with conventional gauze rather than a covering material. The novel ability of irreversible membrane dressings to absorb leachate irreversibly while retaining surface moisture has dramatically improved outcomes in Japan. Our results show that moist wound healing maximizes autologous tissue regeneration, hastens epithelialization, and reduces infection.