bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topical Aspirin administration improves cutaneous wound healing in diabetic mice through a phenotypic switch of wound macrophages toward an anti-inflammatory and pro-resolutive profile characterized by LXA4 release
Authors: Dardenne Christophe , Salon Marie , Authier Hélène , Meunier Etienne , AlaEddine Mohamad , Bernad José , Bouschbacher Marielle , Lefèvre Lise , Pipy Bernard , Coste Agnès 
Published: July 2022

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<p>Diabetic patients present a persistent inflammatory process, leading to impaired wound healing. Since non-healing diabetic wounds management shows limited results, the introduction of advanced therapies targeting and correcting the inflammatory status of macrophages in chronic wounds could be an effective therapeutic strategy to stop the sustained inflammation and to return to healing state. Here, we demonstrated in an excisional skin injury in diet-induced diabesity murine model that topic low-dose Aspirin (36µg/wound/day) administration improved cutaneous wound healing by increasing wound closure through the promotion of the inflammation resolution program of macrophages. Indeed, this treatment increased efferocytosis of wound macrophages from aspirin-treated diabetic mice compared to untreated diabetic mice. We also showed that Aspirin treatment of high fat fed mice oriented the phenotype of wound macrophages toward an anti-inflammatory and pro-resolutive profile characterized by a decrease of LTB4 production. The use of diabetic mice deficient for 5-LOX or 12/15-LOX demonstrated that these two enzymes of acid arachidonic metabolism were essential for the beneficial effect of Aspirin on wound healing. Thus, Aspirin treatment modified the balance between pro- and anti-inflammatory eicosanoids by promoting the synthesis of pro-resolving LXA4 through 5-LOX/LTA4/12/15-LOX signaling. In conclusion, the restoration of anti-inflammatory and pro-resolutive phenotype of wound macrophages by the topical administration of low-dose Aspirin represents a promising therapeutic approach in chronic wounds. </p>
PEMANFAATAN INFORMATION AND COMMUNICATION TECHNOLOGIES (ICT) DALAM PENGELOLAAN ADMINISTRASI SEKOLAH (Studi pada SMAN 5 Bandar Lampung)
Authors: AMIRUDIN AMIRUDIN 
Published: July 2022

Penelitian bertujuan untuk mengetahui pemanfaatan Information and Communication Technologies dalam pengelolaan administrasi sekolah di SMA Negeri 5 Bandar Lampung. Pengumpulan data dalam penelitian ini menggunakan metode kuesioner sebagai metode pokok dan metode interview serta dokumentasi sebagai metode pelengkap. Penelitian ini adalah deskritif kualitatif yang mana dalam pengelolaan data penulis menggambarkan yang ada di lapangan, adapun untuk menganalisis data penulis menggambarkan yang ada di lapangan. Dari hasil penelitian disimpulkan: 1) Kepala sekolah telah melaksanakan pemanfaatan Information and Communication Technologies dalam pengelolaan administrasi sekolah, tetapi belum maksimal, hal ini disebabkan karena kesibukan kepala sekolah, baik mengikuti rapat, mengikuti penataran-penataran yang menyebabkan kepala sekolah belum dapat melaksanakan pengelolaan administrasi dengan baik. 2) Kurangnya dukungan dari staf TU dan guru untuk meningkatkan pengelolaan disiplin kerjanya, hal ini dapat dilihat dari masih adanya staf TU yang datang terlambat, sering tidak masuk, penguasaan Information and Communication Technologies yang belum maksimal. Kata kunci: information and communication technologies, pengelolaan administrasi sekolah
MANAJEMEN MUTU LAYANAN KONSELING: Studi Kasus Layanan Konseling di MAN 1 Kota MetroMANAJEMEN MUTU LAYANAN KONSELING: Studi Kasus Layanan Konseling di MAN 1 Kota Metro
Authors: SUBANDI SUBANDI 
Published: July 2022

Pelaksanaan pendidikan di Indonesia belum menghasilkan sumber daya manusia yang bermutu dan berdaya saing tinggi. Pendidikan belum berhasil menciptakan manusia Indonesia yang cerdas secara spiritual, emosional, sosial, intelektual, dan kinestetik. Padahal kecerdasan merupakan sumber daya vital bagi suatu bangsa. Dari persoalan di atas, maka penulis tertarik untuk meneliti tentang manajemen mutu layanan Konseling sebagai upaya untuk mengaplikasikan konsep manajemen mutu layanan sehingga madrasah mampu meningkatkan mutu layanan bimbingan konseling di Madrasah Aliyah Negeri 1 Kota Metro pada tahun 2015. Hasil penelitian menunjukkan bahwa manajemen mutu layanan konseling meliputi, (i) melakukan pendataan melalui tes dan non tes, (ii) melakukan layanan informasi, layanan kelompok dan individu, layanan belajar, layanan konsultasi, layanan konferensi dan layanan kerja dan layanan home visit, (iii) melakukan pemecahan masalah peserta didik yang terkait dengan pemecahan masalah pendidikan, dan (iv) melakukan bimbingan pendidikan. Kata kunci: layanan konseling, kecerdasan spiritual, emosional, sosial, dan kinestetik
KONSEP MANAJEMEN PENDIDIKAN ISLAM PERSPEKTIF AL-QUR’AN
Authors: FATHONI AHMAD 
Published: July 2022

Manajemen pendidikan adalah manajemen yang diterapkan dalam pengembangan pendidikan. Dalam arti ia merupakan seni dan ilmu mengelola sumber daya pendidikan Islam untuk mencapai tujuan pendidikan Islam secara efektif dan efisien. Berbicara masalah manajemen tentunya tidak bisa lepas dengan empat komponen yang ada yaitu (POAC) planning, organizing, actuating dan controlling. Pandangan para ahli menyimpulkan bahwa Konsep manajemen pendidikan Islam menurut perspektif (pandangan) al-Qur’an adalah sebagai berikut yaitu fleksibel, efektif, effisien, terbuka, cooperative dan partisipatif. Tujuan manajemen pendidikan Islam adalah agar segenap sumber, peralatan ataupun sarana yang ada dalam suatu organisasi tersebut dapat digerakkan sedemikian rupa sehingga dapat menghindarkan sampai tingkat seminimal mungkin segenap pemborosan waktu, tenaga, materil, dan uang guna mencapai tujuan organisasi yang telah ditetapkan terlebih dahulu. Kata kunci: konsep manajemen, pendidikan, al-Qur’an
PEMIKIRAN PENDIDIKAN ISLAM MENURUT PROF. DR. AZUMARDI AZRA, MA
Authors: AMIRUDIN AMIRUDIN 
Published: July 2022

Tujuan pendidikan secara esensial adalah terwujudnya peserta didik yang memahami ilmu-ilmu keislaman dan mengamalkannya dalam kehidupan sehari-hari. Dengan kata lain, terwujudnya insan kamil, yakni manusia yang kembali kepada fitrahnya dan kepada tujuan kehidupan­nya sebagaimana ia berikrar sebagai manusia yang datang dari Allah dan kembali kepada Allah. Pemikiran Azyumardi Azra mengenai pendidikan Islam merupakan hasil pemikiran terhadap pengembagan mutu pendidikan Islam. Pemikiran yang dimaksud adalah tujuan dan kurikulum pendidikan Islam.Adapun mengenai pemikiran Azyumardi Azra terhadap pendidikan Islam yakni perhatiannya terhadap demokratisasi dan modernisasi pendidikan Islam dengan tujuan agar mampu mengangkat martabat lembaga pendidikan islam yang menghasilkan kualitas tinggi. Dalam hal pembaruan, Azyumardi Azra menitikberatkan pada input dan output pendidikan Islam bagi masyarakat. Dengan memadukan nilai-nilai tradisional dan nilai-nilai yang berorientasi ke masa depan. Kata Kunci: Pemikiran Azyumardi Azra, tujuan pendidikan Islam, insan kamil
PERAN AYAH DALAM PERKEMBANGAN DAN PENDIDIKAN ANAK: Studi di Kelurahan Labuhan Ratu Bandar Lampung
Authors: MUHASSIN MOHAMMAD 
Published: July 2022

This research aims to describe the father’s roles in children’s development and education and the impact of the father’s involvement within their process. This is a descriptive qualitative research employing fathers in Kelurahan Labuhan Ratu Bandar Lampung as the informants taken by purposive sampling technique. The result of the research shows that the father’s roles in children’s development and education include teaching children on self-control and social values. In addition, the father’s involvement in children’s development and education gives a positive impact to the children’ cognitive, emotional, and social aspects, as well as their physical condition. Keywords: Father’s roles, children’s development, education
Orthodontic extraction practices: a cross-sectional survey of orthodontists in Australia
Authors: Meade Maurice J. , Dreyer Craig W. 
Published: July 2022

Abstract

Objective
To survey Australian-based orthodontists regarding their opinions on their extraction practices.

Method
A pilot-tested electronic-questionnaire was distributed to 465 members of the Australian Society of Orthodontists. Questions pertained to their demographic details, current extraction rates, changes in prescribed orthodontic extraction patterns over the past 5 to 10 years and the factors that may have influenced decisions.

Results
A response rate of 35.05% was recorded. Orthodontists estimated that they extracted permanent teeth in 21.03% and 22.06% of recently treated adults and children/adolescents presenting with a Class I malocclusion. Respondents were less comfortable carrying out non-extraction treatment in child/adolescent patients (15.4%) than in adult patients (34.7%) when crowding was greater than 6 mm. Most orthodontists (55.89%) who had practiced for more than 5 years believed that the number of patients that were treated by extractions was unchanged over the past 5 to 10 years while 34.55% believed that the proportion had decreased. More experienced orthodontists tended to report increased rather than decreased extraction rates (p = 0.0102). Most of those (88.1–93.17%) who reported decreased extraction rates considered facial aesthetics had a moderate/major influence on their extraction decisions. The increased use of ‘combined’ interproximal reduction (IPR) and arch lengthening in children/adolescents (55.8%) and IPR in adults (85%) was reported by those whose extraction rates had decreased.

Conclusions
Orthodontists extracted permanent teeth in just over 20% of their patients who presented with a Class I malocclusion. Most orthodontists considered that their extraction rates had not changed over the past 5 to 10 years. The increased use of IPR with or without arch lengthening procedures, was reported by those whose extraction rates had decreased over the same time period.
The applicability of the Tanaka and Johnston analysis in a contemporary Western Australian population
Authors: Abaid Sidra , Zafar Sobia , Kruger Estie , Tennant Marc 
Published: July 2022

Abstract

Background/Objective
The Tanaka and Johnston mixed dentition analysis is a widely used method to predict the size of unerupted permanent canines and premolars. The aim of the present study was to determine the applicability of the Tanaka and Johnston analysis to Western Australian adolescents and develop a new regression equation.

Methods
Five hundred participants (323 females, 177 males) meeting the inclusion criteria were selected from private orthodontic clinics. The mesiodistal dimensions of all permanent teeth were retrieved from pre-orthodontic treatment digital dental records using Invisalign® technology (Invisalign®, Align Technology, Santa Clara, CA, USA) and analysed using a predicted value derived from the Tanaka and Johnston analysis. Correlation and linear regression analyses were applied to develop new regression equations.

Result
A significant difference was found between the actual and predicted values derived from the Tanaka and Johnston analysis. A significant correlation was observed between the sum of the permanent mandibular incisors and the sum of the maxillary and mandibular canine and premolars (0.58–0.74). New regression equations and tables were derived from the study population.

Conclusion
The Tanaka and Johnston analysis overestimated the mesiodistal dimensions of permanent canines and premolars. The developed regression equation and tables may be used for orthodontic diagnosis and treatment planning in Western Australian adolescents.
Clear aligners brands and marketing claims: An overview of available information on the web
Authors: Shi Cynthia , Feng Yanlu , Hsiao Yu-Chen , Smith Julia , Jin Carrol , Farella Mauro , Mei Li 
Published: July 2022

Abstract

Objectives
To investigate the current commercially available clear aligners related to brands, companies, Google trends, and marketing claims presented on their official websites.

Materials and methods
A search was conducted in October 2020 to identify the relevant web-based information, using three languages (English, Chinese, and Korean) and search terms “clear aligner”, , , and in four search engines (Google, Bing, Baidu, and Naver) to identify current clear aligner companies. Each company website was reviewed and assessed for its marketing claims.

Results
A total of 75 clear aligner brands were identified and included in the study, and 280 claims from their official websites were analysed. Most (70.7%) of the companies made claims regarding “aesthetics”, 66.7% made claims regarding “increased comfort”, 58.7% made claims regarding “shorter treatment time”, and 56.0% of the companies made claims regarding “superior material”. Other claims were made regarding their “novel technology”, “superior hygiene”, “tracking Apps”, “remote monitoring”, and “reduced in-office visits”. Of these marketing claims, only 4.5% cited references supporting the company’s website claims; however, the references were mainly derived from internal company research.

Conclusions
Using three languages (English, Chinese, and Korean), 75 different brands of clear aligners were currently found online. Most of the marketing claims from the clear aligner companies’ official websites were not referenced to quality scientific studies. Clinicians and patients should critically appraise the content of company claims and advertisements.
Cerebral microbleeds in a young patient – case presentation with rare disease association and literature review
Authors: Tihamér Máté , István Mihály , Krisztina Kelemen , Attila Szász József , Szabolcs Szatmári 
Published: July 2022

Abstract
During the coronavirus pandemic neurology departments were forced to treat diseases that had hitherto been treated by other specialities. In our case presentation, we describe an unusual association of two diseases that raised interesting questions regarding differential diagnostics and has not yet been presented in the literature.
A 34-year-old male patient was admitted to the neurology department with an urgent referral because of impaired speech comprehension and expression upon awakening. He had a history of anticoagulant therapy for thrombosis of the posterior tibial artery, discontinued after two weeks. Physical examination revealed a 1 cm diameter painful lump in the subcutis of his right thigh and a systolic murmur over the mitral and aortic valves. Nonenhanced head CT showed a small hemorrhage near the occipital horn of the left ventricle, which could not explain the mixed aphasia. In addition, the SWAN MRI sequence showed supra- and infratentorial microbleeds, suggesting cavernomatosis, which was confirmed by the detection of another typical popcorn-like bleeding cavernoma on repeated MRI examination. Due to the heart murmurs and positive inflammatory markers, a detailed cardiac examination was warranted, confirming infective endocarditis caused by Streptococcus gordonii. Due to COVID-19-related regulations the patient couldn’t be transferred to the Department of Cardiology or Infectious Diseases, thus his treatment and follow-up was carried out at the Department of Neurology. Following targeted antibiotic treatment the patient’s symptoms resolved and he underwent successful cardiac surgery 7 weeks after his discharge in a symptom-free state.
The peculiarity of the case lies in the fact that the clinical picture and course of the disease, consistent with the diagnosis of infective endocarditis suggested cerebral septic emboli with microbleeds, but cerebral cavernomatosis was confirmed by brain imaging.
Estimating of Additive, Dominance, and Epistatic Genetic Variance in Eucalypt Hybrid Population
Authors: Garel Makouanzi Ekomono Chrissy , Philippe Vigneron 
Published: July 2022

Abstract
Additive, dominance and epistasis genetic variances were estimated from analysis of a clonally replicated full-sib progeny test grown in the Republic of Congo. Phenotypic variance components were estimated for ages 4 through 25 months for growth and at ages 8 and 18 months for ecophysiological traits. The estimation of genetics effects was derived from the individual mixed model. Genetic structure was incorporated into variances and covariance’s effects based on markers information. The detected genetic effects of epistasis are significant in some traits. This study shows that epistasis variance can be non-zero and contribute significantly to the genetic variability of growth and ecophysiological traits. We conclude that the epistatic effect for quantitative traits may exist, but estimates may not be obtained, either because the models used are inappropriate or because the epistasis variance is too small relative to other components of the genetic variance to be estimated.
Karakteristik histokimia daun Ridan (Nephelium maingayi Hiern – Sapindaceae) dari Provinsi Riau
Authors: Sofiyanti Nery , Fitmawati Fitmawati , Isda Mayta Novaliza , Lestari Asri Ria 
Published: July 2022

Ridan (Nephelium maingayi) merupakan salah satu anggota famili Sapindaceae yang tersebar di Provinsi Riau, namun tidak banyak dibudi dayakan karena buah yang berukuran kecil dan agak masam. Pada penelitian ini bertujuan untuk mengetahui karakteristik histokimia daun ridan. Senyawa metabolit yang diuji adalah tannin, flavonoid, alkaloid serta lipid. Sampel yang digunakan adalah daun ridan yang sudah dewasa. Irisan sampel dilakukan menggunakan hand microtome, dan selanjutnya diuji dengan larutan FeCl3 (tannin), NaOH (flavonoid), Wagner (alkaloid) dan Sudan III (lipid). Sampel diamati dan didokumentasikan menggunakan mikroskop digital. Uji histokimia menunjukan bahwa bagian daun ridan (N. maingayi) pada umumnya mengandung tannin, alkaloid, lipid dan flavonoid. Uji lipid menunjukan hasil negatif pada jaringan kortek dan empulur tangkai anak daun, serta pada jaringan empulur ibu tangkai daun. Hasil kajian ini memberikan informasi tambahan pada kajian histokimia anggota dari marga Nephelium.
Pengaruh ekstrak rumput laut (Eucheuma cottoni) terhadap kadar malondialdehid dan spermatozoa tikus (Rattus norvegicus L.) yang diinduksi natrium nitrit
Authors: Wirastuti Dessy Sukma , Sukmaningsih A S S A , Sudirga Sang Ketut 
Published: July 2022

Produk daging olahan adalah salah satu jenis pangan yang mudah mengalami kerusakan. Kerusakan pada produk daging olahan diakibatkan karena adanya pertumbuhan mikroorganisme. Menanggulangi hal tersebut, perusahaan pengolahan daging banyak menambahkan bahan tambahan pangan (BTP) yaitu natrium nitrit (NaNO2). Akumulasi nitrit yang berlebih dalam tubuh dapat menimbulkan efek yang merugikan pada sistem reproduksi. Penelitian oleh Pavlova et al. (2017) menemukan terjadi penurunan berat epididimis dan pengurangan jumlah spermatoa tikus yang diberi paparan NaNO2 tinggi. Rumput laut Eucheuma cottoni mengandung antioksidan yang dapat menetralkan sifat oksidatif yang ditimbulkan oleh NaNO2. Penelitian ini dilakukan untuk mengetahui pengaruh ekstrak rumput laut Eucheuma cottoni terhadap kadar Malondialdehid (MDA) dan spermatozoa pada tikus putih (Rattus norvegicus L.) jantan yang diinduksi NaNO2. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari kontrol negatif (K-), kontrol positif (K+), perlakuan dosis 1 (P1), perlakuan dosis 2 (P2) dan perlakuan 3 (P3). Kontrol negatif (K-) diberikan aquades sedangkan kontrol positif diberikan natrium nitrit dosis 22,5 mg/kg BB. Perlakuan dosis 1,2 dan 3 diberikan metode kombinasi natrium nitrit dan ekstrak rumput laut dosis 150 mg/kgBB/hari (P1), 300 mg/kgBB/hari (P2), dan 450 mg/kgBB/hari (P3). Pemberian perlakuan dilakukan selama 45 hari. Adapun variabel penelitian terdiri dari kadar MDA (Malondialdehid) pada serum dan kualitas spermatozoa meliputi integritas membran, viabilitas, motilitas dan morfologi spermatozoa dari tikus putih jantan. Analisis data dilakukan melalui uji statistik One Way Anova dan dilanjutkan dengan uji Duncan. . Hasil penelitian menunjukkan ekstrak rumput laut dosis 150 mg/kgBB mampu menurunkan kadar MDA (Malondialdehid), meningkatkan motilitas, viabilitas, integritas membran dan morfologi spermatozoa secara signifikan.
Respon Pertumbuhan dan Produksi Tanaman Sawi Pakchoy (Brasiaca Rapa L.) terhadap Jenis Media Tanam dan Dosis Pupuk NPK
Authors: Bahri Bahri , Sutejo Sutejo , Waruwu Waruwu 
Published: July 2022

Penelitian ini bertujuan untuk mengetahui respon tanaman sawi terhadap dua jenis tanah Mineral dan Tanah Sawah serta dosis pupuk NPK terhadap produksi tanaman sawi dalam polybag. Penelitian ini dilaksanakan di Kelurahan Karang Ketuan, Lubuklinggau pada bulan Desember 2016 sampai Januari 2017. Penelitian ini menggunakan metode eksperimental dengan Rancangan Acak Kelompok yang disusun secara factorial. Faktor pertama dalam penelitian jenis tanah (T); T1= Tanah Mineral (inseptisol) , T2 = Tanah Sawah. Faktor kedua yaitu perlakuan dosis pupuk NPK (P) terdiri dari 3 taraf, yaitu: N1= 150 Kg / ha setara dengan 0,75 gram / polybag, N2 = 200 Kg / ha setara dengan 1 gram / polybag, N3 = 250 Kg / ha setara dengan 1,25 gram / polybag. Berdasarkan kedua faktor perlakuan tersebut didapatkan 6 kombinasi perlakuan dengan ulangan sebanyak 4 kali, sehingga di peroleh 24 unit percobaan masing – masing unit terdiri dari 3 sampel tanaman. Hasil penelitian menunjukan bahwa T2 memberikan hasil terbaik pada peubah tinggi tanaman, lebar daun, jumlah daun, berat brangkasan basah dan berat brangkasan kering. Perlakuan pupuk NPK majemuk dengan dosis 200 Kg/ha setara dengan 1 gram/polybag (N2) memberikan hasil terbaik terhadap peubah tinggi tanaman, lebar daun, berat brangkasan basah dan berat kering brangkasan, Tabulasi data menunjukkan bahwa interaksi perlakuan T2N2 cendrung lebih banyak memberikan respon terbaik terhadap peubah jumlah daun, berat brangkasan basah dan berat kering brangkasan. Kata kunci: Inseptisol, sawah, sawi pakchoi
Memes com conceitos de mais de dois mil anos:
Authors: Gomes Daniele , Romanazzi Freire Carolina 
Published: July 2022

O presente artigo tem como objetivo discutir teoricamente as possibilidades didáticas a presença do gênero textual meme (DAWKINS, 1978) como um intercessor (DELEUZE, 2013) viável de dar suporte ao material didático no ensino da Filosofia na educação básica. Se pensarmos a Filosofia como experiência crítico-criativa do pensamento e não como um conteúdo reproduzido acriticamente, devemos refletir como o encontro com os diferentes discursos podem ser intensificadores no que concerne ao conhecimento filosófico. Sendo os memes formas de comunicação criadas a partir de situações corriqueiras e com uma forma de linguagem potencialmente criativa que podem propor múltiplas leituras sobre diferentes temas, como esse recurso pode ser utilizado pelos docentes em tempos de ensino remoto e também, presencial? Que potencialidades podemos alcançar quando usados de maneira estratégica? Eles podem fomentar experiências filosóficas? Essas são algumas das indagações mobilizadas para propor a irreverência (KOHAN, 2013) enquanto uma categoria que colabora para o mapeamento do presente (MASSCHELEIN, 2008) e o desenvolvimento de uma perspectiva filosófica do ensino de Filosofia.