bluuebunny/crossref_metadata_2025_split huggingface dataset:
The feasibility and benefit of unsupervised at-home training of minimally invasive surgical skills
Authors: Joosten Maja , Hillemans Vera , Bökkerink Guus M. J. , de Blaauw Ivo , Verhoeven Bas H. , Botden Sanne M. B. I. 
Published: July 2022

Abstract
Background
Simulation-based training may be used to acquire MIS skills. While mostly done in a simulation center, it is proposed that this training can be undertaken at-home as well. The aim of this study is to evaluate whether unsupervised at-home training and assessment of MIS skills is feasible and results in increased MIS skills.

Methods
Medical doctors and senior medical students were tested on their innate abilities by performing a pre-test on a take-home simulator. Henceforth, they followed a two-week interval training practicing two advanced MIS skills (an interrupted suture with knot tying task and a precise peg transfer task) and subsequently performed a post-test. Both tests and all training moments were performed at home. Performance was measured using motion analysis software (SurgTrac) and by expert-assessment and self-assessment using a competency assessment tool for MIS suturing (LS-CAT).

Results
A total of 38 participants enrolled in the study. Participants improved significantly between the pre-test and the post-test for both tasks. They were faster (632 s vs. 213 s, p < 0.001) and more efficient (distance of instrument tips: 9.8 m vs. 3.4 m, p = 0.001) in the suturing task. Total LS-CAT scores, rated by an expert, improved significantly with a decrease from 36 at the pre-test to 20 at the post-test (p < 0.001) and showed a strong correlation with self-assessment scores (R 0.771, p < 0.001).
The precise peg transfer task was completed faster (300 s vs. 163 s, p < 0.001) and more efficient as well (14.8 m vs. 5.7 m, p = 0.005). Additionally, they placed more rings correctly (7 vs. 12, p = 0.010).

Conclusion
Unsupervised at-home training and assessment of MIS skills is feasible and resulted in an evident increase in skills. Especially in times of less exposure in the clinical setting and less education on training locations this can aid in improving MIS skills.
A new cloud autonomous system as a service for multi-mobile robots
Authors: Nasr Aida A. 
Published: July 2022

AbstractToday, mobile robot is used in most industrial and commercial fields. It can improve and carry out work complex tasks quickly and efficiently. However, using swarm robots to execute some tasks requires a complex system for assigning robots to these tasks. The main issue in the robot control systems is the limited facilities of robot embedded system components. Although, some researchers used cloud computing to develop robot services. They didn’t use the cloud for solving robot control issues. In this paper, we have used cloud computing for controlling robots to solve the problem of limited robot processing components. The main advantage of using cloud computing is its intensive computing power. This advantage motivates us to propose a new autonomous system for multi-mobile robots as a services-based cloud computing. The proposed system consists of three phases: clustering phase, allocation phase, and path planning phase. It groups all tasks/duties into clusters using the k-means algorithm. After that, it finds the optimal path for each robot to execute its duties in the cluster based on the Nearest neighbor and Harris Hawks Optimizer (HHO). The proposed system is compared with systems that use a genetic algorithm, simulated annealing algorithm, and HHO algorithm. From the finding, we find that the proposed system is more efficient than the other systems in terms of decision time, throughput, and the total distance of each robot.
Development of a new preclinical model to study early implant loss: a validation study in the beagle dog
Authors: Liñares Antonio , Verdeja Raul , Pippenger Benjamin , Muñoz Fernando , López-Peña Mónica , Blanco Juan 
Published: July 2022

Abstract
Objectives
To develop a new preclinical model to study early implant loss, where local infection conditions would impair the implant osseointegration.

Materials and methods
Forty-eight smooth, 2.9-mm diameter experimental implants were placed in the mandible of 8 beagle dogs (3 in each side). In half of the animals (test group, n = 24 implants), the implants received ligatures around the implant-abutment connection. In the other half, no ligatures were placed (control group, n = 24 implants). Four weeks later, implants were extracted in a flapless approach and standard 3.3-mm diameter SLActive implants were placed into the same osteotomy site without any further drilling. Eight weeks after the second implantation, animals were sacrificed and analyzed in terms of implant survival.

Results
After 8 weeks of healing, 4 implants were lost in the control group and 14 in the test group. This corresponded to a 17.4% of early implant loss in the control group and 58.3% in the test. Most of the early failures occurred within the first 5 weeks of healing.

Conclusions
Implants placed in a pre-contaminated site present higher early loss than those placed in a non-contaminated site. This study represents a valid and robust preclinical model to study mechanisms and reduction of early implant loss as new technologies become available.

Clinical relevance
Scientific rationale for the study: There is lack of animal models to study early implant loss. Thus, a proposal of a new model is presented. With the validation of this model, new technologies can be implemented to prevent early implant loss.
Resection of brain lesions with a neuroendoscopic ultrasonic aspirator — a systematic literature review
Authors: Ebel Florian , Greuter Ladina , Guzman Raphael , Soleman Jehuda 
Published: July 2022

AbstractThe development of minimally invasive neuroendoscopy has advanced in recent years. The introduction of the neuroendoscopic ultrasonic aspirator (NUA) increased the treatment spectrum of neuroendoscopy. This review aimed to present a systematic overview of the extent of resection, lesion characteristics, technical aspects, complications, and clinical outcomes related to using the NUA. Articles were identified by searching the PubMed/Medline, Embase, and Web of Science database through June 2022 with restriction to the last 20 years. We included case series, case reports, clinical trials, controlled clinical trials, meta-analyses, randomized controlled trials, reviews, and systematic reviews written in English. Studies reporting on endonasal approach or hematoma evacuation using the NUA were excluded. The references of the identified studies were reviewed as well. Nine full-text articles were included in the analysis, with a total of 40 patients who underwent surgery for a brain tumor using NUA. The most common underlying pathology treated by NUA was colloid cyst (17.5%), pilocytic astrocytoma (12.5%), subependymal giant cell astrocytoma (7.5%), subependymoma (7.5%), and craniopharyngioma (7.5%). Complete or near-total resection was achieved in 62.5%. The most frequently reported postoperative complication was secondary hydrocephalus (10%), meningitis/-encephalitis (7.5%), cognitive impairment (7.5%), and subdural hygroma (7.5%). In one case (2.5%), surgery-related death occurred due to a severe course of meningoencephalitis. According to the preliminary data, NUA seems to be a safe and efficient minimally invasive alternative to conventional microscopic resection of brain tumors. Further studies to investigate advantages and disadvantages of using the NUA are needed.
(NH4)2[Co(H2O)6]2V10O28·4H2O Vs. (NH4)2[Ni(H2O)6]2V10O28·4H2O: Structural, Spectral and Thermal Analyses and Evaluation of Their Antibacterial Activities
Authors: Mamdouh Ayat-Allah , Ibrahim Ahmed B. M. , Reyad Nour El-Houda A. , Elsayed Tarek R. , Santos Isabel Cordeiro , Paulo António , Mahfouz Refaat M. 
Published: July 2022

AbstractThis paper presents the synthesis of two cluster compounds {(NH4)2[Co(H2O)6]2V10O28·4H2O (C1) and (NH4)2[Ni(H2O)6]2V10O28·4H2O (C2)} which were obtained as single crystals suitable for XRD analysis that revealed their crystallization in the monoclinic (C2/c) and triclinic (P-1) space groups, respectively. Additionally, C1 and C2 were characterized using CHN analysis and FT-IR spectroscopy and their thermal decomposition mechanisms were investigated. The antibacterial activities of both compounds were determined against three human pathogenic bacterial strains {Bacillus cereus ATCC 33,018, Escherichia coli O157:H7 and Pseudomonas aeruginosa ATCC 9027} and one phytopathogenic bacterial strain {Ralstonia solanacearum}, while drug standards {chloramphenicol and streptomycin} were used as control. The inhibitory activity and the minimum inhibitory concentration (MIC) values of the tested compounds clearly indicated higher antibacterial activities of the nickel compound against B. cereus ATCC 33,018, E. coli O157 and R. solanacearum with MIC values of 3.150, 3.150 and 6.300 mg/ml, respectively. On the other hand, (NH4)2[Co(H2O)6]2V10O28·4H2O exhibited higher antibacterial activity against P. aeruginosa ATCC 9027 (MIC value of 6.300 mg/ml) in comparison to the nickel analog. In general, the measured activities are lower than that obtained for the standards except for the higher activity given by C2 in comparison to streptomycin against the R. solanacearum strain.
Resident perceptions of riverbank erosion and shoreline protection: a mixed-methods case study from Bangladesh
Authors: Rahman Mizanur , Popke Jeff , Crawford Thomas W. 
Published: July 2022

AbstractRiverbank erosion is a common hazard in Bangladesh, posing a significant threat to homes, properties, and livelihoods. In recent years, the government of Bangladesh has intensified efforts to mitigate riverbank erosion by hardening shorelines, including the building of concrete revetments, but the local dynamics of these interventions are not well documented. To address this, we present results from a study of community-level response to a 2-mile long concrete revetment recently constructed in the administrative district of Ramgati, in the lower Meghna River basin of Bangladesh. Our study combines quantitative analysis of data from a household survey with qualitative data from semi-structured interviews to assess resident perceptions of the new revetment and its effect on the landscape of riverbank erosion hazard. The study finds, firstly, that hazard awareness is widespread but may be influenced by livelihood factors related to the dynamics of displacement and resettlement. Second, we find that that the negative impacts of riverbank erosion vary spatially. Hazard perception in Ramgati is significantly influenced by the physical location of the household, with those residing closer to the river and in unprotected zones north and south of the revetment expressing much greater worry that they will lose their homes, and believing that this will happen much sooner than residents further away or in the zone now protected by the embankment. As an empirically grounded case study, our findings add to the literature on riverbank erosion in Bangladesh and perception studies focused on water-based hazards in similar settings globally.
Hypothalamic microstructure and function are related to body mass, but not mental or cognitive abilities across the adult lifespan
Authors: Spindler Melanie , Thiel Christiane M. 
Published: July 2022

AbstractPhysical, mental, and cognitive resources are essential for healthy aging. Aging impacts on the structural integrity of various brain regions, including the hippocampus. Even though recent rodent studies hint towards a critical role of the hypothalamus, there is limited evidence on functional consequences of age-related changes of this region in humans. Given its central role in metabolic regulation and affective processing and its connections to the hippocampus, it is plausible that hypothalamic integrity and connectivity are associated with functional age-related decline. We used data of n = 369 participants (18–88 years) from the Cambridge Centre for Ageing and Neuroscience repository to determine functional impacts of potential changes in hypothalamic microstructure across the lifespan. First, we identified age-related changes in microstructure as a function of physical, mental, and cognitive health and compared those findings to changes in hippocampal microstructure. Second, we investigated the relationship of hypothalamic microstructure and resting-state functional connectivity and related those changes to age as well as physical health. Our results showed that hypothalamic microstructure is not affected by depressive symptoms (mental health), cognitive performance (cognitive health), and comparatively stable across the lifespan, but affected by body mass (physical health). Furthermore, body mass changes connectivity to limbic regions including the hippocampus, amygdala, and nucleus accumbens, suggesting functional alterations in the metabolic and reward systems. Our results demonstrate that hypothalamic structure and function are affected by body mass, focused on neural density and dispersion, but not inflammation. Still, observed effect sizes were small, encouraging detailed investigations of individual hypothalamic subunits.
Deep-learning-based instrument detection for intra-operative robotic assistance
Authors: Badilla-Solórzano Jorge , Spindeldreier Svenja , Ihler Sontje , Gellrich Nils-Claudius , Spalthoff Simon 
Published: July 2022

AbstractPurpose:Robotic scrub nurses have the potential to become an attractive solution for the operating room. Surgical instrument detection is a fundamental task for these systems, which is the focus of this work. We address the detection of the complete surgery set for wisdom teeth extraction, and propose a data augmentation technique tailored for this task.Methods:Using a robotic scrub nurse system, we create a dataset of 369 unique multi-instrument images with manual annotations. We then propose the Mask-Based Object Insertion method, capable of automatically generating a large amount of synthetic images. By using both real and artificial data, different Mask R-CNN models are trained and evaluated.Results:Our experiments reveal that models trained on the synthetic data created with our method achieve comparable performance to that of models trained on real images. Moreover, we demonstrate that the combination of real and our artificial data can lead to a superior level of generalization.Conclusion:The proposed data augmentation technique is capable of dramatically reducing the labelling work required for training a deep-learning-based detection algorithm. A dataset for the complete instrument set for wisdom teeth extraction is made available for the scientific community, as well as the raw information required for the generation of the synthetic data (https://github.com/Jorebs/Deep-learning-based-instrument-detection-for-intra operative-robotic-assistance).
Cardiac Arrest Treatment Center Differences in Sedation and Analgesia Dosing During Targeted Temperature Management
Authors: Ceric Ameldina , May Teresa L. , Lybeck Anna , Cronberg Tobias , Seder David B. , Riker Richard R. , Hassager Christian , Kjaergaard Jesper , Haxhija Zana , Friberg Hans , Dankiewicz Josef , Nielsen Niklas 
Published: July 2022

Abstract
Background
Sedation and analgesia are recommended during targeted temperature management (TTM) after cardiac arrest, but there are few data to provide guidance on dosing to bedside clinicians. We evaluated differences in patient-level sedation and analgesia dosing in an international multicenter TTM trial to better characterize current practice and clinically important outcomes.

Methods
A total 950 patients in the international TTM trial were randomly assigned to a TTM of 33 °C or 36 °C after resuscitation from cardiac arrest in 36 intensive care units.
We recorded cumulative doses of sedative and analgesic drugs at 12, 24, and 48 h and normalized to midazolam and fentanyl equivalents. We compared number of medications used, dosing, and titration among centers by using multivariable models, including common severity of illness factors. We also compared dosing with time to awakening, incidence of clinical seizures, and survival.

Results
A total of 614 patients at 18 centers were analyzed. Propofol (70%) and fentanyl (51%) were most frequently used. The average dosages of midazolam and fentanyl equivalents were 0.13 (0.07, 0.22) mg/kg/h and 1.16 (0.49, 1.81) µg/kg/h, respectively.
There were significant differences in number of medications (p < 0.001), average dosages (p < 0.001), and titration at all time points between centers (p < 0.001), and the outcomes of patients in these centers were associated with all parameters described in the multivariate analysis,
except for a difference in the titration of sedatives between 12 and 24 h (p = 0.40). There were associations between higher dosing at 48 h (p = 0.003, odds ratio [OR] 1.75)
and increased titration of analgesics between 24 and 48 h (p = 0.005, OR 4.89) with awakening after 5 days, increased titration of sedatives between 24 and 48 h with awakening after 5 days (p < 0.001, OR > 100), and increased titration of sedatives between 24 and 48 h with a higher incidence of clinical seizures in the multivariate analysis (p = 0.04, OR 240). There were also significant associations between decreased titration of analgesics and survival at 6 months in the multivariate analysis (p = 0.048).

Conclusions
There is significant variation in choice of drug, dosing, and titration when providing sedation and analgesics between centers. Sedation and analgesia dosing and titration were associated with delayed awakening, incidence of clinical seizures, and survival, but the causal relation of these findings cannot be proven.
Indicating biologics for chronic rhinosinusitis with nasal polyps (CRSwNP)
Authors: Klimek Ludger , Förster-Ruhrmann Ulrike , Beule Achim G. , Chaker Adam M. , Hagemann Jan , Klimek Felix , Casper Ingrid , Huppertz Tilman , Hoffmann Thomas K. , Dazert Stefan , Deitmer Thomas , Olze Heidi , Strieth Sebastian , Wrede Holger , Schlenter Wolfgang , Welkoborsky Hans-Jürgen , Wollenberg Barbara , Bergmann Christoph , Cuevas Mandy , Beutner Caroline , Gröger Moritz , Becker Sven 
Published: July 2022

Summary
Background
Chronic rhinosinusitis with nasal polyps (CRSwNP), an inflammatory disease of the paranasal mucosa, is primarily characterized by type 2 inflammation. Three antibodies (dupilumab, omalizumab, and mepolizumab) are now approved for the treatment of severe CRSwNP. Documentation of disease severity during the course of treatment is essential.

Methods
A literature search of Medline, PubMed, and the national and international trial and guideline register, and the Cochrane Library was performed to analyze the immunology of CRSwNP and determine the evidence for the effect of dupilumab, omalizumab, and mepolizumab in this disease. This has resulted in 3 position papers prepared by our group of authors, which form the basis of this summarizing review.

Results
Based on the information from the international literature, recommendations for the use of dupilumab, omalizumab, and mepolizumab in CRSwNP in the German health care system are given by an expert panel.

Conclusion
Dupilumab, omalizumab, and mepolizumab are approved for patients 18 years of age and older with CRSwNP as add-on therapy to intranasal corticosteroids when, for dupilumab and mepolizumab, therapy with systemic corticosteroids and/or surgery does not achieve sufficient disease control. Therapy with omalizumab is indicated when therapy with intranasal corticosteroids does not result in sufficient disease control. Dedicated recommendations for the documentation of the use in the German health care system are given, which are based on the position papers of our author group already published on this topic.
Discounting for Money, Food, and Sex, over the Menstrual Cycle
Authors: Vincent Benjamin T. , Sztwiertnia Mariola , Koomen Rebecca , Warren Jasmine G. 
Published: July 2022

AbstractSexual desire, physical activity, economic choices and other behaviours fluctuate over the menstrual cycle. However, we have an incomplete understanding of how preferences for smaller sooner or larger later rewards (known as delay discounting) change over the menstrual cycle. In this pre-registered, cross-sectional study, Bayesian linear and quadratic binomial regression analyses provide compelling evidence that delay discounting does change over the menstrual cycle. Data from 203 naturally cycling women show increased discounting (preference for more immediate rewards) mid-cycle, which is at least partially driven by changes in fertility. This study provides evidence for a robust and broad-spectrum increase in delay discounting (Cohen’shranging from 0.1 to 0.4) around the fertile point in the menstrual cycle across multiple commodities (money, food, and sex). We also show, for the first time, that discounting changes over the menstrual cycle in a pseudo-control group of 99 women on hormonal contraception. Interestingly, such women increase their discounting of sex toward the end of the menstrual phase — possibly reflecting a prioritisation of bonding-related sexual activity before menstrual onset.
Assessment of soil loss rate using GIS–RUSLE interface in Tashat Watershed, Northwestern Ethiopia
Authors: Mengie Mequanent Abathun , Hagos Yonas Gebresilasie , Malede Demelash Ademe , Andualem Tesfa Gebrie 
Published: July 2022

AbstractThe erosion of soil is one of the most difficult and ongoing problems caused by deforestation, improper cultivation, uncontrolled grazing, and other anthropogenic activities. As a result, assessing the level and quantity of soil erosion is essential for agricultural productivity and natural resource management. Thus, the goal of this study was to quantify soil loss rates and identify hotspot locations in the Tashat watershed, Abay basin, Ethiopia. Thematic factor maps, comprising rainfall erosivity factor (R), soil erodibility factor (K), topography factor (LS), cover and management factor (C), and conservation practices factor (P), were integrated using remote sensing data and the GIS 10.3.1 environment to estimate soil loss using RUSLE. The findings indicated that the watershed annual soil loss varies from none in the lower part to 3970.6 t ha−1 year−1 in the middle, with a mean annual soil loss of 64.2 t ha−1 year−1. The total estimated annual soil loss was 61,885,742.9 tons from the total watershed area of 48,348.4 ha. The majority of these soil erosion-affected places are geographically located in the watershed middle steepest slope portion, where Cambic Arenosols with higher soil erodibility character than other soil types in the research area predominate. Thus, sustainable soil and water conservation techniques should be implemented in the steepest middle section of the study area by respecting and acknowledging watershed logic, people, and watershed potentials.