bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obsessive–compulsive symptoms in ACTG1-associated Baraitser-Winter cerebrofrontofacial syndrome
Authors: Göbel Theresa , Berninger Lea , Schlump Andrea , Feige Bernd , Runge Kimon , Nickel Kathrin , Schiele Miriam A. , van Elst Ludger Tebartz , Hotz Alrun , Alter Svenja , Domschke Katharina , Tzschach Andreas , Endres Dominique 
Published: October 2022

AbstractSymptoms of obsessive–compulsive disorder (OCD) may rarely occur in the context of genetic syndromes. So far, an association between obsessive–compulsive symptoms (OCS) and ACTG1-associated Baraitser-Winter cerebrofrontofacial syndrome has not been described as yet. A thoroughly phenotyped patient with OCS and ACTG1-associated Baraitser-Winter cerebrofrontofacial syndrome is presented. The 25-year-old male patient was admitted to in-patient psychiatric care due to OCD. A whole-exome sequencing analysis was initiated as the patient also showed an autistic personality structure, below average intelligence measures, craniofacial dysmorphia signs, sensorineural hearing loss, and sinus cavernoma as well as subtle cardiac and ophthalmological alterations. The diagnosis of Baraitser-Winter cerebrofrontofacial syndrome type 2 was confirmed by the detection of a heterozygous likely pathogenic variant in the ACTG1 gene [c.1003C > T; p.(Arg335Cys), ACMG class 4]. The automated analysis of magnetic resonance imaging (MRI) revealed changes in the orbitofrontal, parietal, and occipital cortex of both sides and in the right mesiotemporal cortex. Electroencephalography (EEG) revealed intermittent rhythmic delta activity in the occipital and right temporal areas. Right mesiotemporal MRI and EEG alterations could be caused by a small brain parenchymal defect with hemosiderin deposits after a cavernomectomy. This paradigmatic case provides evidence of syndromic OCS in ACTG1-associated Baraitser-Winter cerebrofrontofacial syndrome. The MRI findings are compatible with a dysfunction of the cortico-striato-thalamo-cortical loops involved in OCD. If a common pathophysiology is confirmed in future studies, corresponding patients with Baraitser-Winter cerebrofrontofacial syndrome type 2 should be screened for OCS. The association may also contribute to a better understanding of OCD pathophysiology.
Assessment of trends in an integrated climate metric—analysis of 200 mbar zonal wind for the period 1958–2021
Authors: Wan Nenghan , Lin Xiaomao , Pielke Roger A. 
Published: October 2022

AbstractUsing two reanalysis datasets on latitude bands of nearly equal area, we analyze the trend of 200 mbar zonal wind anomalies for the period 1958–2021 as well as annual-mean latitude of the zonal mean jet stream. We do not find much change of 200 mbar zonal wind in both two datasets although the increasing trend over the high latitude bands from 45 to 61°S for both datasets, and the decreasing trend in 0–5°N and 0–10°S for ERA5 are significant with small magnitudes. In addition, the polar jet core moves poleward in the Northern Hemisphere, but the movement is not statistically significant, while no poleward shift at all has occurred in the Southern Hemisphere. This work provides us a way to look for the long-term changes and variability in atmospheric circulation.
The emerging digital infrastructure for research in the humanities
Authors: Waters Donald J. 
Published: October 2022

AbstractThis article advances the thesis that three decades of investments by national and international funders, combined with those of scholars, technologists, librarians, archivists, and their institutions, have resulted in a digital infrastructure in the humanities that is now capable of supporting end-to-end research workflows. The article refers to key developments in the epigraphy and paleography of the premodern period. It draws primarily on work in classical studies but also highlights related work in the adjacent disciplines of Egyptology, ancient Near East studies, and medieval studies. The argument makes a case that much has been achieved but it does not declare “mission accomplished.” The capabilities of the infrastructure remain unevenly distributed within and across disciplines, institutions, and regions. Moreover, the components, including the links between steps in the workflow, are generally far from user-friendly and seamless in operation. Because further refinements and additional capacities are still much needed, the article concludes with a discussion of key priorities for future work.
Assessment of the residential Finnish wolf population combines DNA captures, citizen observations and mortality data using a Bayesian state-space model
Authors: Mäntyniemi Samu , Helle Inari , Kojola Ilpo 
Published: October 2022

AbstractAssessment of the Finnish wolf population relies on multiple sources of information. This paper describes how Bayesian inference is used to pool the information contained in different data sets (point observations, non-invasive genetics, known mortalities) for the estimation of the number of territories occupied by family packs and pairs. The output of the assessment model is a joint probability distribution, which describes current knowledge about the number of wolves within each territory. The joint distribution can be used to derive probability distributions for the total number of wolves in all territories and for the pack status within each territory. Most of the data set comprises of both voluntary-provided point observations and DNA samples provided by volunteers and research personnel. The new method reduces the role of expert judgement in the assessment process, providing increased transparency and repeatability.
Significance of abnormal blood coagulation in patients with chronic myelomonocytic leukemia
Authors: Weinfurtner Christoph , Geissler Klaus 
Published: October 2022

SummaryIn a retrospective study, we analyzed the prevalence of subnormal prothrombin time (PT) values in 104 patients with chronic myelomonocytic leukemia (CMML), their potential prognostic impact, and potential correlations with clinicolaboratory features. Reduced PT values (< 70%) were found in 45/104 (43%) patients. The median survival of patients with reduced PT values was significantly shorter than in patients with normal PT (19 vs. 49 months, p = 0.006). Patients with reduced PT had higher leukocyte counts, a higher proportion of circulating blast cells, and lower platelet counts. In patients for whom clinical information was available, there was no difference in the incidence of bleeding complications between patients with or without reduced PT. Our results show a high prevalence of plasmatic coagulation abnormalities in patients with CMML, which were associated with laboratory features of advanced disease. Moreover, subnormal PT values were identified as a new prognostic marker. Reduced PT values do not seem to have a clinical impact regarding bleeding complications.
Banking the Unbanked: Conceptualizing Success of the Business Correspondent Model
Authors: Goel Kanika , Bandara Wasana , Gable Guy 
Published: October 2022

AbstractThe Business Correspondent (BC) model is an IT-enabled business process outsourcing initiative to provide financial services to the unbanked. It is a complex banking system involving multiple actors, system elements and settings, intended to address financial exclusion. Given the BC-Model’s potentially significant role in economic sustainability, it is important to evaluate its success. Efforts to measure the success of the BC-Model have been limited to date; this paper therefore presents a conceptual framework of BC-Model-Success consisting of six dimensions- economic, strategic, technological, customer satisfaction, employee satisfaction, and social, resulting from a three-phase study design. The relevance of the framework was empirically validated across four implementations of the BC-Model. The resulting framework provides strong theoretical foundations for understanding what BC model success is, for assisting practitioners with evaluating the success of the BC-Model and with identifying possible improvements, and for facilitating future research on the BC-Model.
Adaptive Algorithms for Meta-Induction
Authors: Ortner Ronald 
Published: October 2022

AbstractWork in online learning traditionally considered induction-friendly (e.g. stochastic with a fixed distribution) and induction-hostile (adversarial) settings separately. While algorithms like Exp3 that have been developed for the adversarial setting are applicable to the stochastic setting as well, the guarantees that can be obtained are usually worse than those that are available for algorithms that are specifically designed for stochastic settings. Only recently, there is an increasing interest in algorithms that give (near-)optimal guarantees with respect to the underlying setting, even in case its nature is unknown to the learner. In this paper, we review various online learning algorithms that are able to adapt to the hardness of the underlying problem setting. While our focus lies on the application of adaptive algorithms as meta-inductive methods that combine given base methods, concerning theoretical properties we are also interested in guarantees that go beyond a comparison to the best fixed base learner.
Next Generation Sequencing for Potential Regulated Genes and Micro-RNAs of Early Growth Response-1 in the Esophageal Squamous Cell Carcinoma
Authors: Tseng Yen-Chiang , Shu Chih-Wen , Chang Hui-Min , Lin Yi-Hsuan , Tseng Yen-Han , Hsu Han-Shui , Goan Yih-Gang , Tseng Ching-Jiunn 
Published: October 2022

AbstractEsophageal cancer has a poor prognosis due to its aggressiveness and low survival rate. In Ease Asia, esophageal squamous cell carcinoma (ESCC) outnumbers esophageal adenocarcinoma (EAC). The ESCC patients still have high mortality despite modern surgical resection and neoadjuvant treatment. Determining patient and outcome prognostic factors is critical in ESCC treatment. In esophageal cancer, early growth response-1 (Egr-1) is a tumor suppressor gene, but the mechanism and associated genes are unknown. The study utilizes RNA interference method, the platform of Next Generation Sequencing (NGS) and bioinformatics analysis to investigate the influences after the Egr-1 gene slicing on the ESCC cells. The heat maps of differentially expressed mRNA and microRNAs were analyzed using the algorithm, Burrows-Wheller Aligner. The study showed that the expression of 51 mRNA and 26 microRNAs have significant changes in ESCC cells after Egr-1 knockdown. The KEGG enrichment analysis linked Egr-1-regulated genes and microRNAs. Egr-1 interactions with these genes and microRNAs may be important in tumor progression. In conclusions, this study provided the transcriptome patterns and relating pathway analysis for Egr-1 knockdown in ESCC cells. The mRNA and microRNAs altered by Egr-1 gene silencing might provide key information in the treatment of ESCC.
Algorithms for rescheduling jobs with a LIFO buffer to minimize the weighted number of late jobs
Authors: Pferschy Ulrich , Resch Julia , Righini Giovanni 
Published: October 2022

AbstractRescheduling can help to improve the quality of a schedule with respect to an initially given sequence. In this paper, we consider the possibility of rescheduling jobs arriving for processing at a single machine under the following limitations: (a) jobs can only be moved toward the end of the schedule and not toward the front, and (b) when a job is taken out of the sequence, it is put on a buffer of limited capacity before being reinserted in its new position closer to the end of the sequence. The buffer is organized as a stack with a last-in/first-out policy. As an objective function, we consider the minimization of the weighted number of late jobs. For this NP-hard problem, we first provide two different integer linear programming (ILP) formulations. Furthermore, we develop a branch-and-bound algorithm with a branching rule based on the movement of jobs. Then a new pseudo-polynomial dynamic programming algorithm is presented which utilizes dominance criteria and an efficient handling of states. Our computational experiments with up to 100 jobs show that this algorithm performs remarkably well and can be seen as the current method of choice.
What I cannot do without you. Towards a truly embedded and embodied account of the socially extended mind
Authors: Candiotto Laura 
Published: October 2022

Abstract
Through a discussion of the socially extended mind, this paper advances the “not possible without principle” as an alternative to the social parity principle. By charging the social parity principle with reductionism about the social dimension of socially extended processes, the paper offers a new argumentative strategy for the socially extended mind that stresses its existential significance. The “not possible without principle” shows that not only is something more achieved through socially located processes of knowledge building, but also that, and more importantly, what is achieved is something that would not have been possible without social interaction. The social parity principle states that the result of an activity achieved via social interaction should be assumed functionally equivalent to a solitary investigation and is characterized by multiple realisability. Contrary to the social parity principle, the “not possible without principle” holds that the result would not have been achieved without the social interaction between (at least) two agents with specific existential needs. The socially extended mind never happens in a void. This means that the "not possible without" principle should be located in real-life, affectively charged, embodied experiences of skilful interactions between agents. This fundamental conceptual change via reference to the “existential necessity” that regulates socially extended processes is necessary in order to effectively lead the socially extended mind to a truly embedded and embodied account.
Dysfunktionales Erziehungsverhalten von Müttern und Vätern mit kleinen Kindern. Ergebnisse der Folgestudie Kinder in Deutschland – KiD 0–3
Authors: Liel Christoph , Seilbeck Carolin , Lux Ulrike , Lorenz Simon , Ulrich Susanne Marlene 
Published: October 2022

ZusammenfassungBeide Eltern sind für die kindliche Sozialisation wesentlich, aber es ist wenig über Unterschiede und Beeinflussungen im Erziehungsverhalten von Müttern und Vätern bekannt.Eltern von ein- bis sechsjährigen Kindern (n = 550) wurden zu psychosozialen Merkmalen und dysfunktionalem Erziehungsverhalten (Überreagieren, Feindseligkeit und Nachgiebigkeit) befragt. Mittels multipler Regression und Actor-Partner-Interdependence-Modell wurde der Einfluss von elterlichen, kindlichen und sozialen Merkmalen auf das Erziehungsverhalten von Müttern und Vätern unabhängig und abhängig voneinander untersucht.Mütter berichteten im Mittel mehr überreagierendes und Väter mehr feindseliges bzw. nachgiebiges Erziehungsverhalten. Zusammenhänge zeigten sich für negative Emotionalität des Kindes mit allen Formen, für elterlichen Ärger mit Überreagieren bzw. Feindseligkeit und für Partnerschaftsunzufriedenheit mit Nachgiebigkeit. Unterschiede und Partnereffekte fielen schwach aus, z. B. mit einem komplementär gerichteten Einfluss von Überreagieren/Nachgiebigkeit von Vätern auf Nachgiebigkeit/Überreagieren der Mütter.Zukünftige Forschung sollte somit die elterliche Interdependenz in Familien berücksichtigen.
Videobasierte Erfassung wissensbasierten Verarbeitens als Teilprozess der professionellen Unterrichtswahrnehmung – Analyse eines geschlossenen und offenen Verfahrens
Authors: Müller Madeleine M. , Gold Bernadette 
Published: October 2022

ZusammenfassungDie professionelle Wahrnehmung als Erkennen und wissensbasiertes Analysieren relevanter Ereignisse und Situationen gilt als eine grundlegende Voraussetzung für das professionelle Handeln einer Lehrkraft. Zur Erfassung werden meist kontextualisierte Instrumente mit Videostimulus verwendet, welche sowohl geschlossene Erfassungsformate wie Ratingitems oder auch offene Erfassungsformate wie schriftliche Kommentierungen verwenden. Da die Zusammenhänge zwischen den Erfassungsformaten unter der Verwendung unterschiedlicher Videos in bisherigen Studien eher niedrig ausfallen, geht die vorliegende Querschnittsstudie (N = 309 Lehramtsstudierende des Bachelors und Masters) der Frage nach, inwiefern sich Zusammenhänge bei Verwendung eines identischen Videostimulus zeigen, und betrachtet Hinweise auf Konstrukt- und Kriteriumsvalidität der beiden Erfassungsformate. Zusammenfassend deuten niedrige bis moderate Zusammenhänge zwischen geschlossener und offener Erfassungsart zur Messung der professionellen Wahrnehmung darauf hin, dass nicht auf die Messung desselben Konstruktes geschlossen werden kann. Weiterhin zeigte sich kein eindeutiges Zusammenhangsmuster mit dem professionellen Wissen über Klassenführung, das für die Überlegenheit einer Erfassungsart sprach. Erwartungskonform konnten zwischen beiden Erfassungsformaten Gruppenunterschiede im Sinne der Kriteriumsvalidität identifiziert werden, wobei die geschlossene Erfassung zu Teilen sensitiver war.
Zur Unterscheidung von Tat- und Rechtsfragen bei der Begutachtung der Schuldfähigkeit
Authors: Lichtenthäler Sören 
Published: October 2022

ZusammenfassungAufgabe der forensischen Sachverständigen ist es, abstrakt gesagt, den sie beauftragenden Rechtsanwendern bestimmte Informationen zu vermitteln, die diese für ihre Entscheidungsfindung benötigen. Stellungnahmen zu Fragen des inländischen Rechts haben sie sich zu enthalten. Die Grenze der Aufgabenbereiche verläuft demnach entlang der Unterscheidung, was eine Tatsachenfrage und was eine Rechtsfrage ist. Diese wurde und wird in rechtstheoretischer Hinsicht aber als nicht unproblematisch erachtet (ihre Möglichkeit teilweise sogar geleugnet). Der folgende Beitrag geht deshalb zunächst der allgemeinen Frage nach, wie im Kontext des Sachverständigenbeweises zwischen Tat- und Rechtsfragen differenziert werden kann, wofür auf eine syllogistische Rekonstruktion des Rechtsanwendungsvorgangs zurückgegriffen wird. Sodann soll ein Augenmerk auf die besonderen Probleme gelegt werden, die die Unterscheidung im Zusammenhang mit Schuldfähigkeitsgutachten aufwirft. Dabei wird die These entwickelt, dass es bei der Beurteilung der Einsichts- und Steuerungsfähigkeit nicht um eine empirisch-naturwissenschaftliche, sondern um die praktisch-normative Frage geht, wem als einem (formell) vernünftigen Wesen zu begegnen ist und wem nicht, was die Aufgabenverteilung zwischen Rechtsanwender und Sachverständigem prekär erscheinen lässt.
How threatening are people with mental disability? it depends on the type of threat and the disability
Authors: Aubé Benoite , Rohmer Odile , Yzerbyt Vincent 
Published: October 2022

AbstractThere is clear evidence that people with mental disability suffer from discrimination at school, at work, and in society. Less is known about the psychological processes and perceptions that guide such behaviors and even less if these perceptions vary according to the type of disability. Our objective was to build on well-established social psychological models and investigate the perceptions (i.e., stereotypes, perceived threats, and emotions) of people towards different types of mental disability. Participants from two francophone countries completed a questionnaire measuring their perceptions towards 18 mental disabilities and their familiarity with disability (N = 560). As expected, results revealed heterogeneous perceptions across groups. Moreover, perceived threats mediated the link between the stereotype of warmth and emotions. Surprisingly, greater familiarity with mental disability went along with greater derogation. This research nuances the overly generalized perceptions often associated with mental disability. We discuss implications for the reduction of discrimination against people with mental disability.
The positive effects of combined breathing techniques and cold exposure on perceived stress: a randomised trial
Authors: Kopplin Cristopher Siegfried , Rosenthal Louisa 
Published: October 2022

AbstractA pranayama-inspired breathing technique, cold exposure, and their combined application were assessed for their potential to reduce perceived stress in adults and compared to a control group. An experiment involving four groups was conducted, yielding separate cells for breathing technique-only and cold exposure-only, as well as a combined treatment and a control group. Eighty-six individuals participated in the study. Perceived stress is measured employing the 10-item version of the Perceived Stress Scale (PSS-10) and the 20-item version of the Perceived Stress Questionnaire (PSQ). The instruments exhibit a substantial correlation (r = 0.842, p < 0.001). The combined group exhibited a medium to large positive effect on perceived stress compared to the control group. The breathing technique and cold exposure on their own were not found to yield substantial effects, indicating synergies between both exercises. Combinations of breathing techniques and cold exposure may be employed to decrease individuals’ perceived stress.
Identifying Gaps and Challenges in Global Pesticide Legislation that Impact the Protection of Consumer Health: Rice as a Case Study
Authors: Kubiak-Hardiman Patricia , Haughey Simon A. , Meneely Julie , Miller Sarah , Banerjee Kaushik , Elliott Christopher T. 
Published: October 2022

AbstractWith continued global population expansion, food production will have to increase with crops protected against the growing menace of pests, requiring the increased use of pesticides globally to ensure that agricultural production is optimised and remains economically viable. The aim of this systematic review was to perform an in-depth analysis of pesticide legislation, focusing on rice, to understand the gaps that exist in the harmonisation across different countries. Tricyclazole, carbendazim, thiamethoxam and acephate were considered as these received the highest numbers of RASFF notifications and alerts due to their presence in rice. Global differences in regulations cause trade issues, especially when developing countries use unauthorised pesticides or different MRLs. Discrepancies in the registration and regulation of sales were found to be a global problem. Sales of pesticides and resulting residues in developing countries that are banned in the EU or US is highly concerning. Evidence suggests farmers’ education regarding pesticide use and protection must be increased, particularly as climate change is impacting pesticide use patterns and their bio-efficacy. In conclusion, international pesticide regulations have been implemented to protect consumer health, the environment and facilitate international trade. However, the absence of national MRLs in some countries or non-alignments with Codex MRLs raise significant concerns regarding some pesticides in relation to the protection of consumer health and the use of mixtures versus single pesticides. Additionally, global differences in pesticide regulation highlight problems in trade, especially when developing countries use unauthorised pesticides or when MRLs are not in agreement.