bluuebunny/crossref_metadata_2025_split huggingface dataset:
The crystal structure of 4-((6-fluoropyridin-2-yloxy)methyl)benzonitrile, C13H9FN2O
Authors: Lu Zhi-Qiang 
Published: May 2022

Abstract
C13H9FN2O, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 7.4664(8) Å, b = 8.2700(7) Å, c = 10.0709(11) Å, α = 76.991(8)°, β = 88.403(9)°, γ = 63.619(10)° V = 540.93(10) Å3, Z = 2, R

gt
(F) = 0.0534, wR

ref

(F
2
) = 0.1644, T = 293(2) K.
Preparation and bonding mechanisms of polymer/metal hybrid composite by nano molding technology
Authors: Liu Xi , Li Ying , Long Ling , Wang Hailong , Guo Qingfeng , Wang Qingchun , Qi Jing , Chen Jia , Long Yan , Liu Ji , Zhou Zuowan 
Published: May 2022

Abstract
With the development of nano molding technology (NMT), the polymer/metal hybrid (PMH) composites have made great progress in industries like automobile, aircraft, and boat. The bonding structure and bonding strength are the key factors ruling the application of PMH. In this work, the PMH containing polyphenylene sulfide (PPS) and Al alloy was prepared by NMT, and the surface treating of Al alloy and the bonding mechanism of PMH has been studied. The results reveal that the bonding strength between metal and polymer shows dependence on the pore structure of the metal surface, which could be controlled by changing the anodizing voltage and time. The PMH in which the Al plate was anodized at 15 V for 6 h achieves the best bonding strength of 1,543 N. The morphological analysis reveals that there forms an anchor and bolt structure in the interface of PPS and Al plate, which bonds the polymer and metal tightly. In addition, the chemical interaction between PPS and Al was confirmed by attenuated total reflection (ATR) infrared spectroscopy, which indicates that both physical and chemical effects contribute to the bonding strength of the PMH. This PMH has great potential of being used as alternative to traditional pure metal components, especially the packing materials of automobiles, electronic products, and furniture.
The structure design of mobile charging piles
Authors: Wu Zhongming , Wang Lanxin , Lu Junfeng , Sun Li 
Published: May 2022

Abstract
The simple instalment of mobile charging piles benefits for its convenient layout, while dynamic arrangements of those charging piles through mobile mode make up for the insufficient number of fixed charging piles, which meets the growing charging demand under the increasing popularity of electric vehicles. According to the application requirements of mobile charging piles, CATIA software was used to model the structure, of which strength and reliability were analysed under four load conditions. Our results have demonstrated that the maximum deformation value of the structure is 3.07 mm, and the maximum stress is 134.41 MPa, which is within the safety range of the selected materials. In addition, the gravity centre of the charging pile is located at the bottom of the structure, and thus the stability meets the requirements. Taken together, our research provided a beneficial reference for future engineering practice.
Effects and mechanism of filler content on thermal conductivity of composites: a case study on plasticized polyvinyl chloride/graphite composites
Authors: Zhang Han , Yang Zhangbin , Su Keshun , Huang Wenxin , Zhang Jun 
Published: May 2022

Abstract
Thermally conductive polymer composites that retain mechanics and processing properties have attracted significant attention because of promising high thermal conductivity. Herein, plasticized polyvinyl chloride (P-PVC)/graphite composites were successfully prepared via melt blending. Following the addition of graphite rising from 0 to 300 phr, the thermal conductivity of P-PVC/graphite composites increases from 0.18 to 3.01 W m−1 K−1. The thermal conductivity of P-PVC/graphite composites with 300 phr graphite is 17 times that of the P-PVC matrix. P-PVC/graphite composites with high thermal conductivity have excellent performance in thermal management for LEDs. Therefore, the high thermal conductivity allows for the LED’s temperature to drop 44%, compared with the P-PVC matrix, at 1.5 V. The notably cooling effect provides the ideas for the future application of the P-PVC/graphite composites in the thermal management for electronic components.
Logonomic signs as three-phase constraints of multimodal social semiosis
Authors: Fomin Ivan 
Published: May 2022

Abstract
The article introduces the concept of the logonomic sign as an elaboration on Hodge and Kress’s promising yet under-examined ideas about logonomic systems. Logonomic signs are defined as socially devised signs that constrain multimodal semiosis by restricting who is able to produce what signs under what circumstances. Based on the Peircean categories, the functioning of logonomic signs is modeled as a three-phase process of (1) logonomic understanding (production of the meaning that is the Initial Interpretant of a logonomic sign), (2) logonomic actualization (production of the actual semiotic event that is the Dynamical Interpretant of a logonomic sign), and (3) logonomic reproduction ([re]production of the semiotic Habit that is the Final Interpretant of a logonomic sign). Based on Kull’s theory of evolution of semiotic systems, logonomic signs are theorized as mechanisms of retention and standardization of semiotic Habits. The mechanism of reproduction of logonomic signs is modeled as a sign in which past logonomic semioses function as Objects by being iconically represented by similar current logonomic semioses functioning as Representamens, and in which future logonomic semioses are produced as Interpretants. The methodological potential of the proposed concept is discussed in the context of the integrative transdisciplinary capacity of semiotics in social research.
Резонансна структура перерізів розсіяння повільних електронів на атомі кальцію
Authors: Gedeon V.F. , Lazur V.Yu. , Gedeon S.V. , Yehiazarian O.V. 
Published: May 2022

З використанням розширеної БСР-версiї R-матричного методу проведено систематичне дослiдження розсiяння електронiв на нейтральному атомi кальцiю в дiапазонi енергiй зiткнення до 4,3 еВ. Для точного представлення хвильових функцiй мiшенi використовується метод сильного зв’язку з наборами залежних вiд терму неортогональних орбiталей та сплайн-представленнями для базисних функцiй. Розклад для сильного зв’язку включає 39 зв’язаних станiв нейтрального кальцiю, що охоплюють усi стани вiд основного до 4s8s 1S. Детально дослiджено складну резонансну структуру проiнтегрованих за кутом повних перерiзiв пружного е + Са-розсiяння та збудження станiв 4s4p 3Po, 3d4s 3De, 3d4s 1De, 4s4p 1Po і 4s5s 3Se атома Ca електронним ударом. Спостережуванi структури пов’язано з конкретними автовiдривними станами системи налiтаючий електрон + атом Ca. Визначено положення i ширини виявлених резонансiв та проведено їхню спектроскопiчну класифiкацiю.
Indonesian Adaptation and Validation of The Child-Adolescent Perfectionism Scale – Short Form (CAPS-SF)
Authors: Marcellina Sonia , Lubis Fitriani Yustikasari 
Published: May 2022

This study aimed to adapt and examine the psychometric properties of The Child-Adolescent Perfectionism Scale – Short Form (CAPS – SF) in an Indonesian sample. In Indonesia, research on perfectionism is being developed, but there is no measurement for adolescent perfectionism that can be used. Therefore, a valid and reliable measurement is needed. The Child-Adolescent Perfectionism Scale – Short Form (CAPS – SF) developed by Bento et al. is an instrument consisting of 2 dimensions of Socially Prescribed Perfectionism and Self-Oriented Perfectionism with a total of 9 items that can measure perfectionism in children and adolescents. The adaptation process followed the guidelines established by the International Test Commission such as translation, cognitive interview, and test of the pre-final Indonesian version which involved 322 adolescents aged 13-15 years who lived in Indonesia. Reliability test using Cronbach's Alpha and CFA, which was used to measure the construct validity, showed that the nine items in adapted The Child-Adolescent Perfectionism Scale – Short Form (CAPS – SF) could be used to measure the perfectionism of Indonesian adolescents.
Differentiating Bell’s Palsy From Lyme-Related Facial Palsy
Authors: Guez-Barber Danielle , Swami Sanjeev K , Harrison Jacqueline B , McGuire Jennifer L 
Published: May 2022

BACKGROUND AND OBJECTIVES
To describe the etiology and clinical course of pediatric acute-onset unilateral peripheral facial palsy (FP), to define factors that distinguish Bell’s palsy from Lyme-related FP (LRFP), and to determine if early corticosteroid use impacts facial strength recovery in Bell’s palsy or LRFP.

METHODS
Retrospective cohort study of children 1 to 18 years old who received clinical care within our pediatric clinical care network (Lyme-endemic region) between 2013 and 2018 for acute-onset unilateral peripheral FP.

RESULTS
The study included 306 children; 82 (27%) had LRFP, 209 (68%) had Bell’s palsy, and 15 (5%) had FP of different etiology. Most children with LRFP presented between June and November (93%), and compared with Bell’s palsy, more often had a preceding systemic prodrome, including fever, malaise, headache, myalgias, and/or arthralgias (55% vs 6%, P &lt; .001). Neuroimaging and lumbar puncture did not add diagnostic value in isolated FP. Of the 226 children with Bell’s palsy or LRFP with documented follow-up, FP was resolved in all but 1. There was no association between ultimate parent/clinician assessment of recovery and early corticosteroid use.

CONCLUSIONS
Bell’s palsy and LRFP were common causes of pediatric FP in our Lyme endemic region. Systemic prodrome and calendar month may help distinguish LRFP from Bell’s palsy at FP onset, guiding antibiotic use. Early corticosteroid use did not impact our measures of recovery, although subtle abnormalities may not have been appreciated, and time to recovery could not be assessed. Future prospective studies using standardized assessment tools at regular follow-up intervals are necessary.
Circulating free DNA in hypertensive patients with high cardiovascular risk
Authors: Trofimova E. A. , Kireeva V. V. , Usoltsev Yu. K. , Kirilchik S. V. , Lepekhova S. A. , Apartsin K. A. 
Published: May 2022

Aim. To evaluate the level of circulating free nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) in hypertensive patients with high cardiovascular risk.Material and methods. The study included 70 patients, of which 51 were patients with hypertension (HTN) and 19 were healthy. The study of the level of circulating free nDNA and mtDNA was carried out using quantitative polymerase chain reaction (PCR). Additionally, demographic data, comorbidities, risk factors, heredity, results of complete blood count and biochemical blood tests, electrocardiography and echocardiography were analyzed.Results. The level of nDNA in HN patients was significantly higher than in healthy patients: Me (LQ; UQ) — 227 (110; 370) copies/mL and 88 (62; 116) copies/ml, respectively (p<0,0001). In hypertensive patients with a very high cardiovascular risk, the level of nDNA and mtDNA was significantly higher compared to healthy participants: 294 (154; 489) copies/ml versus 88 (62; 116) copies/ml, p<0,0001; 56731 (42531; 129375) copies/mL versus 35156 (18325; 54956) copies/mL, p=0,015.Conclusion. The level of circulating free DNA in hypertensive patients with very high cardiovascular risk is significantly increased, and therefore this parameter can be a cardiovascular risk marker.
Twenty-four-hour profile of peripheral and central blood pressure in young patients with high-normal blood pressure and hypertension
Authors: Silkina S. B. , Antropova O. N. , Osipova I. V. 
Published: May 2022

Aim. To evaluate indicators of daily monitoring of peripheral and central blood pressure in young patients with high-normal blood pressure (HNBP) and essential hypertension (HTN).Material and methods. One hundred twelve patients with HNBP or untreated hypertension aged 25-44 years were included. General clinical investigations were performed. An office blood pressure (BP) were assessed using an automatic BP monitor OMRON M2 Basic. Twenty-four-hour ambulotary BP monitoring (ABPM) on the brachial artery and aorta was carried out for 24 hours using the BpLAB system (OOO Petr Telegin) with an integrated Vasotens system. Depending on BP, patients were divided into groups: with HNBP and hypertension. Statistical processing and comparative analysis of the obtained data were carried out.Results. HNBP group consisted of 47 patients, while the HTN group consisted of 65 patients. The mean age of patients was 34,7±3,2 years. The parameters of daytime and nighttime peripheral BP had significant differences between the HNBP and HTN groups. Aortic BP monitoring revealed following differences: in patients with HTN, central BP values during the day and at night reflected higher values compared to patients from the HNBP group. The number of dippers for peripheral systolic blood pressure (SBP) was more by a quarter (p=0,038) in the HNBP group than in the HTN group. There were no differences in the reduction of diastolic blood pressure (DBP). The reduction in aortic SBP between the groups of HNBP and HTN were comparable. Among hypertensive patients, DBP dippers on the aorta were 20% higher (p=0,04) than in the HNBP group. According to the augmentation and the amplification index reduced to heart rate, there were no significant differences between the groups.Conclusion. Intergroup and intragroup differences were revealed depending on the types of 24-hour profile depending on peripheral and central BP. Reference values and predictive value of central BP require further research.
Predicting the risk of left ventricular diastolic dysfunction in obesity
Authors: Chumakova G. A. , Gritsenko O. V. , Gruzdeva O. V. , Zateev A. V. 
Published: May 2022

Obesity may develop heart failure with preserved ejection fraction, which is based on left ventricular diastolic dysfunction (LV DD). Currently, the search for effective predictors of LV DD is extremely relevant.Aim. To assess the prognostic value of key and additional metabolic risk factors (RFs), neurohumoral and profibrotic factors in the development of LV DD in obese patients.Material and methods. The study included 149 men with general obesity. The mean age was 49,7±7,9 years. The inclusion criteria was the presence of class I-III general obesity. The average body mass index was 32,9±3,6 kg/m2. The exclusion criteria were hypertension, coronary atherosclerosis, type 2 diabetes, as well as LV DD according to transthoracic echocardiography. Depending on the presence of epicardial adiposity, patients were divided into two groups: group 1 — epicardial adipose tissue (EAT) thickness ≥7 mm (n=70), group 2 — EAT <7 mm (n=31). In all patients, the following laboratory parameters were determined in blood serum using enzyme immunoassay: type I and III collagen, Procollagen I C-Terminal Propeptide (PICP), matrix metalloproteinase-3 (MMP-3), transforming growth factor β1, vascular endothelial growth factor, tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-10, C-reactive protein (CRP), adiponectin, soluble leptin receptor, leptin, lipid parameters and free fatty acids (FFA). After 4,7±0,3 years, echocardiography was repeated in order to assess LV diastolic function.Results. Comparative analysis of metabolic risk factors revealed a significant increase in the level of total cholesterol (p=0,001), low-density lipoprotein cholesterol (LDL-C) (p<0,0001), triglycerides (TGs) (p<0,0001). These groups had no differences in such parameters as high-density lipoprotein cholesterol (p=0,09) and glucose (p=0,12). An increase in the level of such pro-inflammatory cytokines as TNF-α (p<0,0001), CRP (p<0,0001), IL-6 (p<0,0001) in group 1 was revealed, while differences in IL-10 (p=0,34) levels were not significant. In group 1, there was a significant increase in leptin levels (p<0,0001), a decrease in levels of adiponectin (p<0,0001) and leptin receptor (p=0,001). In group 1, an increase in the level of all studied profibrotic factors was revealed. After 4,7±0,3 years, repeated echocardiography revealed that selected groups were comparable in such parameters as A, E, E/A, E/e’, e’, and the peak tricuspid regurgitation velocity. There was a significant difference in left atrial volume index (p=0,0003). LV DD was detected in 20 patients. Binary logistic regression revealed the following most significant predictors of LV DD in obese patients: glucose, LDL-C, triglycerides, leptin receptor, leptin, MMP-3, FFA, PICP, and EAT thickness.Conclusion. Thus, the following most significant predictors of LV DD in obese patients were identified glucose, LDL-C, triglycerides, leptin receptor, leptin, MMP-3, FFA, PICP, and EAT thickness.
Features of plasminogen activator inhibitor-1 synthesis by local fat depots of different localization in cardiovascular diseases
Authors: Belik E. V. , Gruzdeva O. V. , Dyleva Yu. A. , Bychkova E. E. , Kuzmina A. A. , Ivanov S. V. , Barbarash O. L. 
Published: May 2022

Aim. To determine the features of expression and secretion of plasminogen activator inhibitor-1 (PAI-1) by subcutaneous, epicardial and perivascular adipocytes depending on the complexity of coronary artery disease (CAD).Material and methods. The study included 86 patients with CAD, including 35 with moderate atherosclerotic lesions of the coronary arteries (CA) (SYNTAX Score ≤22), 22 with severe (SYNTAX Score of 23-31 pints), 29 with extremely severe (SYNTAX Score ≥32). As a comparison group, 52 patients with heart defects were examined. During an elective surgical intervention, adipose tissue (AT) samples were obtained for subsequent cultivation and determination of PAI-1 gene expression and PAI-1 secretion in AT supernatants of various localizations. Statistical analysis was performed using Statistica 10.0.Results. In CAD, PAI-1 production in all three types of AT and plasma PAI-1 concentration were increased compared with patients with heart defects. Epicardial AT (EAT) in CAD was characterized by the maximum levels of expression and secretion of PAI-1 relative to patients with heart defects and subcutaneous and perivascular (PVAT) fat depots. Moderate coronary involvement (adipose tissue <22) is characterized by the lowest expression and secretion of PAI-1 in all types of AT and plasma concentration of PAI-1. Direct correlations of PAI-1 expression and secretion in EAT and PVAT and plasma PAI-1 level with its secretion in EAT in patients with CAD and heart defects were revealed. A direct correlation between the plasma level of PAI-1 and its secretion in PVAT was found only in CAD.Conclusion. In CAD, there is not only an increase in the plasma PAI-1 level, but also an increase in the expression of PAI-1 gene and the secretion of PAI-1 in all three types of AT compared with patients with heart defects. PAI-1 expression and secretion in EAT, PAI-1 plasma level, and age are predictors of severe/extremely severe coronary involvement in CAD.
Hypertension control during the COVID-19 pandemic: results of the MMM2021 in Russia
Authors: Rotar O. P. , Erina A. M. , Boiarinova M. A. , Moguchaia E. V. , Kolesova E. P. , Tolkunova K. M. , Gorshevaya A. R. , Kovalenko K. A. , Smirnova E. A. , Belenikina Ya. A. , Bikushova I. V. , Kercheva M. A. , Svarovskaya A. V. , Petrova M. M. , Kaskaeva D. S. , Shcherbina P. A. , Nikulina S. Yu. , Chernova A. A. , Levshin A. V. , Shabelsky A. O. , Zheleznyak E. I. , Kartashova E. A. , Sharapova Yu. A. , Chernykh T. M. , Derevyanchenko M. V. , Fedotov V. V. , Shaposhnikova N. Yu. , Makeeva E. R. , Ulitina O. V. , Menzorov M. V. , Dolya E. M. , Tanicheva A. A. , Konradi A. O. , Shlyakhto E. V. 
Published: May 2022

Repetitive quarantines and social restrictions during the coronavirus disease 2019 (COVID-19) pandemic have negatively affected the population health in general, and the control of hypertension (HTN) in particular.Aim. To evaluate the control of HTN in the Russian population during the COVID-19 period based on the results of screening for HTN May Measurement Month 2021 (MMM2021).Material and methods. During May-August 2021, 2491 participants from 11 Russian regions took part in the screening. Participation was voluntary without restrictions on sex. All participants were over 18 years of age. During the screening, blood pressure (BP) was measured three times using automatic and mechanical BP monitors. In addition, a questionnaire was filled out on behavioral risk factors, comorbidities and therapy. HTN was diagnosed with systolic BP ≥140 mmHg and/ or diastolic blood pressure ≥90 mmHg and/or taking antihypertensive therapy. The questionnaire included questions about prior COVID-19, vaccinations and their impact on the intake of antihypertensive drugs.Results. The analysis included data from 2461 respondents aged 18 to 92, of which 963 were men (39,1%). The proportion of hypertensive patients was 41,0%, while among them 59,0% took antihypertensives and 30,9% were effectively treated. In comparison with pre-pandemic period according to MMM2018-2019, the higher proportion of HTN patients in the Russian sample was revealed during MMM2021 (41,0% vs 31,3%, p<0,001) with a comparable proportion of patients receiving antihypertensive therapy (60,7% vs 59,0%, p=0,05) and treatment efficacy (28,7% vs 30,9%, p=0,36). Monotherapy was received in 44,7% of cases, while dual and triple combination therapy — in 30,9% and 14,1%, respectively. The majority of respondents (~90%) did not adjust their antihypertensive therapy during the COVID-19 pandemic.Conclusion. According to HTN screening in Russia, there is persistent ineffective control of HTN, which may be due to both the worsening pattern of behavioral risk factors, limited access to healthcare during COVID-19, and the inertia of physicians and low adherence of patients due to the asymptomatic HTN course in the majority.
Personalized management of hypertensive patients: focus on prognostic biomarkers
Authors: Lyamina S. V. , Kalish S. V. , Lyamina N. P. 
Published: May 2022

Aim. To analyze level of circulating biomarkers of plasma vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α) during 3-month therapy with a fixed-dose combination of ramipril/indapamide (Konsilar-D24, AO Vertex, Russia), as well as to evaluate the antihypertensive efficacy of a fixed-dose combination of ramipril/indapamide (Konsilar-D24, JSC “Vertex”, Russia) in hypertensive (HTN) patients with type 2 diabetes (T2D).Material and methods. This prospective open-label study included 44 patients (aged 35 to 60 years) of both sexes with essential grade 1-2 HTN and concomitant compensated T2D, who did not reach the target blood pressure (BP) level using single or dual antihypertensive therapy, as well as patients who did not take antihypertensives. All patients included in the study initially underwent a set of standard clinical, laboratory and functional examinations in accordance with the clinical guidelines for the management of patients with HTN and T2D, as well as an assessment of the level of C-reactive protein, VEGF and TNF-α. Patients were monitored and treated with Konsilar-D24 for 3 months.Results. In 93,2% of patients, individual target BP values were achieved during the first 2-4 weeks of therapy with a fixed combination of ramipril/indapamide (Konsilar-D24). In the subsequent 3-month follow-up, the average daily BP level in all patients ranged from 129/79 mm Hg to 110/70 mm Hg. Three-month Konsilar-D24 therapy showed a decrease in microalbuminuria: the median values of microalbuminuria decreased by 2 times, and the decrease in the maximum recorded values reached 40% of the baseline. Decrease in mean TNF-α values after 3-month therapy with Konsilar-D24 was 33% of the baseline values, while the maximum recorded values during the specified period decreased by 17%. Decrease in median VEGF values after 3-month Konsilar-D24 therapy was 28%, while the maximum value decreased by 7%, the minimum — by 8%.Conclusion. Konsilar-D24 improves the prognosis in hypertensive patients not only by reducing BP to target values, but also by reducing the level of VEGF and TNF-α biomarkers that determine the progression of endothelial dysfunction, diabetic retinopathy, and microalbuminuria.