bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifikasi Reseller Terbaik Penerima Bonus Bulanan Dengan Metode Multi Attribute Utility Theory Pada Toko Ranishop
Authors: Sari Indah Purnama , Yesputra Rolly , Maharani Dewi 
Published: March 2022

Abstract : Ranishop shop is located in Asahan district, with a number of resellers of approximately 241 people. Ranishop stores give bonuses to the five best resellers for each month. The process of selecting the best reseller is carried out by employees with manual calculations. Manual calculations result in the results of the selection taking a long time. Determination of the best reseller, carried out every month. Therefore, an information system based on a decision support system is needed to speed up the process of selecting the best reseller. The decision support system made must be able to facilitate employees and shop owners in making decisions about choosing the best reseller. The calculation process begins by entering period data, alternative data, followed by the process of entering criteria data. The last process, performs calculations using the Multi Attribute Utility Theory (MAUT) method. The results of the calculation process with the MAUT method will be sorted from the highest value to the lowest. Resellers who rank first to fifth will get a monthly bonus. The program created by the researcher is 100% the same as the results of calculations carried out by employees manually, but the MAUT program and method greatly accelerates the work of employees to determine the best reseller, so that work effectiveness is better. Keywords : Decision Support System, Multi Attribute Utility Theory, Reseller. Abstrak: Toko Ranishop berada di kabupaten Asahan, dengan jumlah reseller lebih kurang 241 orang. Toko Ranishop memberikan bonus kepada lima reseller terbaik untuk setiap bulannya. Proses pemilihan reseller terbaik dilakukan oleh karyawan dengan perhitungan secara manual. Perhitungan secara manual mengakibatkan hasil dari pemilihan membutuhkan waktu yang lama. Penentuan reseller terbaik, dilaksanakan setiap bulannya. Oleh karena itu dibutuhkan sistem informasi yang berbasis sistem pendukung keputusan untuk mempercepat proses pemilihan reseller terbaik. Sistem pendukung keputusan yang dibuat harus dapat mempermudah karyawan dan pemilik toko dalam pengambilan keputusan tentang pemilihan reseller terbaik. Proses perhitungan dimulai dengan melakukan memasukkan data periode, data alternatif, dilanjutkan dengan proses memasukkan data kriteria. Proses yang terakhir, melakukan perhitungan menggunakan metode Multi Attribute Utility Theory (MAUT). Hasil proses perhitungan dengan metode MAUT akan di urutkan dari nilai tertinggi sampai yang terendah. Reseller yang menempati urutan pertama sampai urutan kelima, akan mendapatkan bonus bulanan. Program yang dibuat oleh peneliti 100% sama dengan hasil perhitungan yang dilakukan oleh karyawan dengan cara manual, tetapi dengan program dan metode MAUT sangat mempercepat kerja karyawan untuk menentukan reseller terbaik, sehingga efektivitas kerja menjadi lebih baik. Kata Kunci : Sistem Pendukung Keputusan, Multi Attribute Utility Theory, Reseler.PENDAHULUAN
Disminución de la densidad aparente y del módulo dinámico longitudinal de cinco maderas angiospermas después de su exposición al fuego
Authors: Sotomayor Castellanos Javier Ramón 
Published: March 2022

Se presenta la metodología y los resultados de pruebas de reacción al fuego de madera.
El objetivo de la investigación fue verificar si existe una disminución en la densidad y en el módulo dinámico de cinco maderas angiospermas al ser expuestas al fuego.
Se efectuaron pruebas de reacción al fuego de madera proveniente de las especies Tabebuia rosea, Andira inermis, Juglans pyriformis, Quercus spp. y Cordía elaeagnoides. Se realizaron pruebas no destructivas de vibraciones longitudinales, antes y después de exponer al fuego probetas de pequeñas dimensiones. Se determinaron la densidad aparente y el módulo dinámico para antes y después del tratamiento.
Después de su exposición al fuego las densidades de las maderas disminuyeron en las siguientes magnitudes: T. rosea 5,2%, A. inermis 3,7%, J. pyriformis 3,5%, Quercus spp. 2,7% y C. elaeagnoides 2%. Igualmente, los módulos dinámicos se redujeron de la siguiente manera: T. rosea 18,9%, A. inermis 8,2%, J. pyriformis 9,7%, Quercus spp. 9,9% y C. elaeagnoides 3,8%.
Los modelos lineales establecidos para las variables densidad y modulo dinámico indican que es posible predecir los valores esperados para cada una después del tratamiento de fuego por medio de una regresión lineal simple con un alto coeficiente de determinación.
DEVELOPMENT CAPACITY AND SYNERGY OF REGIONAL AUTHORITIES IN EARLY DETECTION OF TERRORISM ACTIONS
Authors: Rusfiana Yudi , Hanifah Abu 
Published: March 2022

Terorisme yang terjadi di Indonesia tidak terlepas dari rangkaian terorisme global, deteksi dini harus dilakukan melalui peningkatan kapasitas dan sinergitas pejabat daerah yang memiliki fungsi intelijen baik di lingkungan TNI, Poliri maupun pemerintah daerah. Optimalisasi kapasitas dan sinergi para pejabat tersebut dapat dilakukan melalui Pemerintah, termasuk pemerintah daerah, dengan mensinergikan deteksi dini melalui berbagai cara, terutama dengan melakukan tindakan sesuai prosedur hukum yang berlaku. Pemerintah melalui pejabat terkait telah melakukan pendekatan melalui tokoh masyarakat, tokoh agama moderat dan mereka yang cenderung radikal dalam rangka mengubah pemikiran radikal menjadi moderat, yaitu dengan memberikan pemahaman yang benar tentang istilah jihad. Dari peningkatan kapasitas dan sinergi tersebut, diharapkan aksi terorisme dapat selalu diantisipasi.
Kata kunci: Deteksi dini, Aparatur Teritorial, Terorisme
Structural Remodeling and Rotational Activity in Persistent/Long-Lasting Atrial Fibrillation: Gender-Effect Differences and Impact on Post-ablation Outcome
Authors: Ríos-Muñoz Gonzalo R. , Soto Nina , Ávila Pablo , Carta Alejandro , Atienza Felipe , Datino Tomás , González-Torrecilla Esteban , Fernández-Avilés Francisco , Arenal Ángel 
Published: March 2022

BackgroundStructural and post-ablation gender differences are reported in atrial fibrillation (AF). We analyzed the gender differences in structural remodeling and AF mechanisms in patients with persistent/long-lasting AF who underwent wide area circumferential pulmonary vein isolation (WACPVI).Materials and MethodsUltra-high-density mapping was used to study atrial remodeling and AF drivers in 85 consecutive patients. Focal and rotational activity (RAc) were identified with the CartoFinder system and activation sequence analysis. The impact of RAc location on post-ablation outcomes was analyzed.ResultsThis study included 64 men and 21 women. RAc was detected in 73.4% of men and 38.1% of women (p = 0.003). RAc patients had higher left atrium (LA) voltage (0.64 ± 0.3 vs. 0.50 ± 0.2 mV; p = 0.01), RAc sites had higher voltage than non-RAc sites 0.77 ± 0.46 vs. 0.53 ± 0.37 mV (p &lt; 0.001). Women had lower LA voltage than men (0.42 vs. 0.64 mV; p &lt; 0.001), including pulmonary vein (PV) antra (0.16 vs. 0.30 mV; p &lt; 0.001) and posterior wall (0.34 vs. 0.51 mV; p &lt; 0.001). RAc in the posterior atrium was recorded in few women (23.8 vs. 54.7% in men; p = 0.014). AF recurrence rate was higher in patients with RAc outside WACPVI than those with all RAc inside WACPVI or no RAc (63.4 vs. 11.1 and 31.0%; p = 0.008 and p = 0.01). Comparison of selected patients using propensity score matching confirmed lower atrial voltage (0.4 ± 0.2 vs. 0.7 ± 0.3 mV; p = 0.007) and less RAc (38 vs. 75%; p = 0.02) in women.ConclusionWomen have shown more advanced structural remodeling at ablation, which is associated with a lower incidence of RAc (usually located outside the WACPVI). These findings could explain post-ablation gender differences.
Diagnostic Accuracy of Subtraction Coronary CT Angiography in Severely Calcified Segments: Comparison Between Readers With Different Levels of Experience
Authors: Li Fang , He Qing , Xu Lixue , Zhou Yan , Sun Yufei , Wang Zhenchang , Xu Yinghao , Yang Zhenghan , He Yi 
Published: March 2022

PurposeSubtraction coronary CT angiography (CCTA) may reduce blooming and beam-hardening artifacts. This study aimed to assess its value in improving the diagnostic accuracy of readers with different experience levels.MethodWe prospectively enrolled patients with target segment who underwent CCTA and invasive coronary angiography (ICA). Target segment images were independently evaluated by three groups of radiologists with different experience levels with CCTA using ICA as the standard reference. Diagnostic accuracy was measured by the area under the curve (AUC), using ≥50% stenosis as the cut-off value.ResultsIn total, 134 target segments with severe calcification from 47 patients were analyzed. The mean specificity of conventional CCTA for each group ranged from 22.4 to 42.2%, which significantly improved with subtraction CCTA, ranging from 81.3 to 85.7% (all p &lt; 0.001). The mean sensitivity of conventional CCTA for each group ranged from 83.3 to 88.0%. Following calcification subtraction, the mean sensitivity decreased for the novice (p &lt; 0.001) and junior (p = 0.017) radiologists but was unchanged for the senior radiologists (p = 0.690). With subtraction CCTA, the mean AUCs of CCTA significantly increased: values ranged from 0.53, 0.54, and 0.61 to 0.70, 0.74, and 0.85 for the novice, junior, and senior groups (all p &lt; 0.001).ConclusionSubtraction CCTA could improve the diagnostic accuracy of radiologists at all experience levels of CCTA interpretation.
Prognostic Value of Coronary Angiography-Derived Fractional Flow Reserve Immediately After Stenting
Authors: Zhou Zuoyi , Zhu Baozhen , Fan Fangfang , Yang Fan , Fang Shu , Wang Zhi , Qiu Lin , Gong Yanjun , Huo Yong 
Published: March 2022

ObjectivesThe aim of this study was to investigate the potential prognostic value of post-percutaneous coronary intervention (PCI) angiography-derived fractional flow reserve (FFR) and its gradient across the stent.BackgroundPost-PCI FFR and its gradient across the stent have been proved to be associated with clinical outcomes. However, little is known about the prognostic value of post-PCI coronary angiography-derived FFR and its gradient across the stent.MethodsPatients diagnosed with coronary heart disease and participated in drug-eluting stent (DES) clinical trials for stent implantation in a single center were included for this retrospective analysis. A novel coronary angiography-derived FFR (caFFR) and its gradient across the stent were calculated offline using two projections from coronary angiography performed after PCI. Clinical follow-up was completed at 9 months after the index procedure and the primary outcome was target vessel failure (TVF), defined as a composite of target vessel-related myocardial infarction (MI), target vessel-related revascularization (TVR), and cardiac death. Coronary angiography was also performed at the 9 months follow-up time to get data of late lumen loss (LLL) and percent diameter stenosis (%DS).ResultsA total of 159 vessels in 136 patients were analyzed. The mean value of post-PCI caFFR was 0.90 ± 0.06. The median value of trans-stent caFFR gradient (ΔcaFFRstent) was 0.04 (interquartile range 0.02–0.08). ΔcaFFRstent&gt;0 was demonstrated in 147 vessels (92.45%). The TVF rate was significantly higher in patients with post-PCI caFFR &lt; 0.90 (4 [8.16%] vs. 1 [1.15%], P = 0.037), which was mainly achieved by the difference between the TVR rate. In the subgroup with lesions located in the left anterior descending coronary artery (LAD), post-PCI caFFR was an independent predictor of LLL (β = −1.07, 95% CI: −1.74 to −0.39, P = 0.002) and %DS at follow-up (β = −30.24, 95% CI: −56.44 to −4.04, P = 0.025), ΔcaFFRstent was an independent predictor of LLL (β=0.98, 95% CI:0.13–1.83, P = 0.026).ConclusionSuboptimal post-PCI caFFR and trans-stent caFFR gradient were common among vessels immediately after stenting. Lower post-PCI caFFR was associated with a higher rate of 9-month TVF. After LAD PCI, both post-PCI caFFR and its gradient across stent were independent predictors of the neointimal proliferation of the target vessel evaluated by LLL and %DS at follow-up.
Case Report: Cardiac Tamponade in Association With Cytokine Release Syndrome Following CAR-T Cell Therapy
Authors: Moriyama Shohei , Fukata Mitsuhiro , Yokoyama Taku , Ueno Shohei , Nunomura Takuya , Mori Yasuo , Kato Koji , Miyamoto Toshihiro , Akashi Koichi 
Published: March 2022

Chimeric antigen receptor T (CAR-T) cell therapy has been shown to have substantial efficacy against refractory hematopoietic malignancies. However, it frequently causes cytokine release syndrome (CRS) as a treatment-specific adverse event. Although cardiovascular events associated with CAR-T cell therapy have been increasingly reported recently, pericardial disease is a rare complication and its clinical course is not well characterized. Here, we report a case of acute pericardial effusion with cardiac tamponade after CAR-T cell therapy.Case SummaryA 59-year-old man with refractory diffuse large B-cell lymphoma underwent CAR-T cell therapy. Grade 2 CRS was observed on day 0; it progressed to grade 4 on day 7 and was accompanied by a fever over 39°C, hypoxia requiring intubation, hypotension requiring the use of a vasopressor agent, and supraventricular tachycardia. Although cardiac function was preserved, marked pericardial effusion with the collapse of the right heart was detected on echocardiography. Since pericardiocentesis was considered to have a high complication risk due to severe myelosuppression, medications for CRS were prioritized. Tocilizumab, an interleukin-6 inhibitor, and high-dose methylprednisolone (1 g/day for 3 days) were administered for the management of severe CRS. On day 8, the pericardial effusion decreased, and the hemodynamic status markedly stabilized. CRS did not exacerbate after the steroid dose was reduced. Further, lymphoma size reduced after the induction of CAR-T cell therapy, and tumor regrowth was not noted at 3 months after CAR-T cell infusion.ConclusionInterleukin-6 pathway inhibitors and corticosteroid therapy should be considered in the context of CRS for significant pericardial effusion after CAR-T cell therapy in the acute phase.
Predicting Soil Organic Carbon Dynamics of Integrated Crop-Livestock System in Brazil Using the CQESTR Model
Authors: Oliveira Janaina M. , Gollany Hero T. , Polumsky Robert Wayne , Madari Beata E. , Leite Luiz F. C. , Machado Pedro L. O. A. , Carvalho Márcia T. M. 
Published: March 2022

Land degradation and reduction in productivity have resulted in losses of soil organic carbon (SOC) in agricultural areas in Brazil. Our objectives were to 1) evaluate the predictive performance of CQESTR model for a tropical savannah; and 2) examine the effect of integrated management systems, including Integrated Crop-Livestock System (ICLS) scenarios on SOC stocks. Two long-term paddocks, under similar edaphic and climate conditions were used in this study. In Paddock 4 (P4) the rotation was corn (Zea mays L.) and 3.5/4.5 years pasture (Urochloa ruziziensis), while rotations in Paddock 5 (P5) included 2.5 years of soybean (Glycine max L.), dryland rice (Oryza sativa L.), and corn followed by 2.5/3.5 years pasture (U. brizantha). Measured and CQESTR simulated values were significantly (0.0001) correlated (r = 0.94) with a mean square deviation (MSD) of 7.55, indicating that the model captured spatial-temporal dynamics of SOC. Predicted SOC increased by 18.0 and 12.04 Mg ha−1 at the rate of 0.90 and 0.60 Mg ha−1 year−1 under current ICLS management for P4 and P5, respectively, by 2039. ICLS increased soil C sequestration compared to simple grain cropping systems under both NT and CT due to high biomass input into the production system.
Identification of lncRNA/circRNA-miRNA-mRNA ceRNA Network as Biomarkers for Hepatocellular Carcinoma
Authors: Chen Shanshan , Zhang Yongchao , Ding Xiaoyan , Li Wei 
Published: March 2022

Background: Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer, with the incidence and mortality rates increasing every year. Despite the improvement of clinical management, substantial challenges remain due to its high recurrence rates and short survival period. This study aimed to identify potential diagnostic and prognostic biomarkers in HCC through bioinformatic analysis.Methods: Datasets from GEO and TCGA databases were used for the bioinformatic analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were carried out by WebGestalt website and clusterProfiler package of R. The STRING database and Cytoscape software were used to establish the protein-protein interaction (PPI) network. The GEPIA website was used to perform expression analyses of the genes. The miRDB, miRWalk, and TargetScan were employed to predict miRNAs and the expression levels of the predicted miRNAs were explored via OncomiR database. LncRNAs were predicted in the StarBase and LncBase while circRNA prediction was performed by the circBank. ROC curve analysis and Kaplan-Meier (KM) survival analysis were performed to evaluate the diagnostic and prognostic value of the gene expression, respectively.Results: A total of 327 upregulated and 422 downregulated overlapping DEGs were identified between HCC tissues and noncancerous liver tissues. The PPI network was constructed with 89 nodes and 178 edges and eight hub genes were selected to predict upstream miRNAs and ceRNAs. A lncRNA/circRNA-miRNA-mRNA network was successfully constructed based on the ceRNA hypothesis, including five lncRNAs (DLGAP1-AS1, GAS5, LINC00665, TYMSOS, and ZFAS1), six circRNAs (hsa_circ_0003209, hsa_circ_0008128, hsa_circ_0020396, hsa_circ_0030051, hsa_circ_0034049, and hsa_circ_0082333), eight miRNAs (hsa-miR-150-5p, hsa-miR-19b-3p, hsa-miR-23b-3p, hsa-miR-26a-5p, hsa-miR-651-5p, hsa-miR-10a-5p, hsa-miR-214-5p and hsa-miR-486-5p), and five mRNAs (CDC6, GINS1, MCM4, MCM6, and MCM7). The ceRNA network can promote HCC progression via cell cycle, DNA replication, and other pathways. Clinical diagnostic and survival analyses demonstrated that the ZFAS1/hsa-miR-150-5p/GINS1 ceRNA regulatory axis had a high diagnostic and prognostic value.Conclusion: These results revealed that cell cycle and DNA replication pathway could be potential pathways to participate in HCC development. The ceRNA network is expected to provide potential biomarkers and therapeutic targets for HCC management, especially the ZFAS1/hsa-miR-150-5p/GINS1 regulatory axis.
Causal Association and Shared Genetics Between Asthma and COVID-19
Authors: Baranova Ancha , Cao Hongbao , Chen Jiu , Zhang Fuquan 
Published: March 2022

ObjectivesRecent studies suggest that asthma may have a protective effect on COVID-19.We aimed to investigate the causality between asthma and two COVID-19 outcomes and explore the mechanisms underlining this connection.MethodsSummary results of GWAS were used for the analyses, including asthma (88,486 cases and 447,859 controls), COVID-19 hospitalization (6,406 hospitalized COVID-19 cases and 902,088 controls), and COVID-19 infection (14,134 COVID-19 cases and 1,284,876 controls). The Mendelian randomization (MR) analysis was performed to evaluate the causal effects of asthma on the two COVID-19 outcomes. A cross-trait meta-analysis was conducted to analyze genetic variants within two loci shared by COVID-19 hospitalization and asthma.ResultsAsthma is associated with decreased risk both for COVID-19 hospitalization (odds ratio (OR): 0.70, 95% confidence interval (CI): 0.70-0.99) and for COVID-19 infection (OR: 0.83, 95%CI: 0.51-0.95). Asthma and COVID-19 share two genome-wide significant genes, including ABO at the 9q34.2 region and OAS2 at the 12q24.13 region. The meta-analysis revealed that ABO and ATXN2 contain variants with pleiotropic effects on both COVID-19 and asthma.ConclusionIn conclusion, our results suggest that genetic liability to asthma is associated with decreased susceptibility to SARS-CoV-2 and to severe COVID-19 disease, which may be due to the protective effects of ongoing inflammation and, possibly, related compensatory responses against COVID-19 in its early stage.
Baseline Inflammatory Status Reveals Dichotomic Immune Mechanisms Involved In Primary-Progressive Multiple Sclerosis Pathology
Authors: Fernández-Velasco José I. , Monreal Enric , Kuhle Jens , Meca-Lallana Virginia , Meca-Lallana José , Izquierdo Guillermo , Oreja-Guevara Celia , Gascón-Giménez Francisco , Sainz de la Maza Susana , Walo-Delgado Paulette E. , Lapuente-Suanzes Paloma , Maceski Aleksandra , Rodríguez-Martín Eulalia , Roldán Ernesto , Villarrubia Noelia , Saiz Albert , Blanco Yolanda , Diaz-Pérez Carolina , Valero-López Gabriel , Diaz-Diaz Judit , Aladro Yolanda , Brieva Luis , Íñiguez Cristina , González-Suárez Inés , Rodríguez de Antonio Luis A , García-Domínguez José M. , Sabin Julia , Llufriu Sara , Masjuan Jaime , Costa-Frossard Lucienne , Villar Luisa M. 
Published: March 2022

ObjectiveTo ascertain the role of inflammation in the response to ocrelizumab in primary-progressive multiple sclerosis (PPMS).MethodsMulticenter prospective study including 69 patients with PPMS who initiated ocrelizumab treatment, classified according to baseline presence [Gd+, n=16] or absence [Gd-, n=53] of gadolinium-enhancing lesions in brain MRI. Ten Gd+ (62.5%) and 41 Gd- patients (77.4%) showed non-evidence of disease activity (NEDA) defined as no disability progression or new MRI lesions after 1 year of treatment. Blood immune cell subsets were characterized by flow cytometry, serum immunoglobulins by nephelometry, and serum neurofilament light-chains (sNfL) by SIMOA. Statistical analyses were corrected with the Bonferroni formula.ResultsMore than 60% of patients reached NEDA after a year of treatment, regardless of their baseline characteristics. In Gd+ patients, it associated with a low repopulation rate of inflammatory B cells accompanied by a reduction of sNfL values 6 months after their first ocrelizumab dose. Patients in Gd- group also had low B cell numbers and sNfL values 6 months after initiating treatment, independent of their treatment response. In these patients, NEDA status was associated with a tolerogenic remodeling of the T and innate immune cell compartments, and with a clear increase of serum IgA levels.ConclusionBaseline inflammation influences which immunological pathways predominate in patients with PPMS. Inflammatory B cells played a pivotal role in the Gd+ group and inflammatory T and innate immune cells in Gd- patients. B cell depletion can modulate both mechanisms.