bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan antara Menyusui dengan Risiko Kanker Ovarium
Authors: ADISASMITA ASRI , MARYANI DINI , DWIPOYONO BAMBANG 
Published: May 2022

ABSTRACTIncidence of Ovarian Cancer, which has a high mortality rate, has been reported to increase since 2008 in Indonesia. A number of protective factors have been identified, one of which is breastfeeding. Despite this, published literature on the association of breastfeeding and ovarian cancer in Indonesia has not been found. The aim of this study is to determine the effect of breastfeeding on ovarian cancer in general, as well as among pre and post menopause patients. This case control study was done at “Dharmais”Cancer Hospital, involving 71 patients with ovarian cancer as the cases, and 140 cervical cancer patients who served as the controls. Interviews were done during follow-up visits. Patients, with adouble primary cancer,were not included in the study. The study shows that lifetime breastfeeding contributes to a decrease in the risk of ovarian cancer by 55% (OR=0.45, 95%CI 0.23 – 0.91) among all cases; the decrease was 53% (OR=0.47, 95%CI 0.23 – 0.96) for those who had previously given birth. These results were adjusted for level of education and menopause status at the time of diagnosis. Women with a history of breastfeeding have a lower risk of having ovarian cancer. The longer the duration of breastfeeding, the lower the risk of having ovarian cancer. The reduced risk was more than 50% for those with a lifetime breastfeeding of 24 months or more. ABSTRAKInsiden kanker ovarium yang memiliki tingkat letalitas tinggi, terus mengalami peningkatan sejak 2008. Beberapa faktor protektifnya telah diidentifkasi, salah satunya adalah menyusui. Meskipun begitu, penelitian yang membahas mengenai faktor tersebut belum banyak dilakukan. Untuk itu, penelitian ini bertujuan untuk mengetahui hubungan antara menyusui dengan risiko kanker ovarium, baik secara umum maupun pada kelompok pre-menopause dan postmenopause. Studi kasus kontrol ini dilakukan di Rumah Sakit Kanker “Dharmais” dengan kasus pasien kanker ovarium (N=71) dan kontrol pasien kanker serviks (n=140). Interview dilakukan pada pasien yang melakukan follow up visit. Pasien dengan kanker primer lain selain kanker ovarium (double primary cancer case) tidak diikutsertakan dalam studi. Hasil penelitian menunjukkan total durasi menyusui seumur hidup (lifetime breastfeeding) berhubungan dengan penurunan risiko terjadinya kanker ovarium sebesar 55% (OR=0,45; 95%CI 0,23–0,91). Pada semua responden yang pernah melahirkan, penurunan risiko sebesar 53% (OR=0,47; 95%CI 0,23–0,96). Nilai tersebut telah dikontrol terhadap variabel pendidikan dan status menopause saat didiagnosis. Penelitian ini menyimpulkan bahwa wanita dengan riwayat menyusui memiliki risiko yang lebih rendah untuk menderita kanker ovarium. Semakin lama durasi menyusui, semakin besar penurunan risiko terjadinya kanker ovarium, yaitu sebesar lebih dari 50% bagi mereka yang menyusui lebih dari 24 bulan.
Febrile Neutropenia pada Pasien Pascakemoterapi
Authors: BUDIANA I NYOMAN GEDE , FEBIANI MELINDA 
Published: May 2022

ABSTRACTFebrile neutropenia (FN) is one of the side effects caused by chemotherapy due to hematopoetic suppression that cause neutropenia and other triggerring factors such as infection. More specifically, FN is defined as the temperature above 38,3oC at once oral temperature measurements or 38,0oC temperature within a period of time more than one hour with neutrophil counts less than 500/mm3 or neutrophil counts less than 1000/mm3 with predicted decline to 500/ mm3 within 48 hours. Febrile neutropenia defined as a medical emergency and oncology which has a high mortality rate. Although currently there is a great development in the prevention and therapy of FN, but this is still the most feared complication of cancer chemotherapy. This article summarizes the important aspects of the FN as well as it’s early detection and management that should be of concern for clinicians who decide to use chemotherapy as one of treatment modality for their patients. ABSTRAKFebrile neutropenia (FN) merupakan salah satu efek samping dari kemoterapi yang disebabkan oleh supresi hematopoesis yang menyebabkan neutropenia ditambah dengan faktor pencetus lain seperti infeksi. Secara lebih spesifik, FN didefinisikan sebagai temperatur di atas 38,3oC pada sekali pengukuran suhu oral atau suhu 38,0oC dalam jangka waktu lebih dari 1 jam dengan hitung jenis neutrofil kurang dari 500/mm3 atau hitung jenis neutrofil kurang dari 1000/mm3 dengan prediksi terjadi penurunan sampai 500/mm3 dalam waktu 48 jam. Febrile neutropenia ditetapkan sebagai kegawatdaruratan medis dan onkologi yang memiliki angka mortalitas tinggi. Walaupun saat ini terdapat perkembangan besar pada prevensi dan terapi FN, FN masih merupakan komplikasi yang paling ditakuti. Artikel ini merangkum aspek-aspek penting dalam deteksi dan penatalaksanaan FN, di mana hal ini perlu menjadi perhatian klinisi yang memutuskan untuk menggunakan kemoterapi sebagai modalitas pengobatan pasien.
Efeito do extrato de própolis sobre o processo de cicatrização da pele: uma revisão sistemática
Authors: Pereira Thercyo Ariell Costa , Silva Francisco Laurindo da 
Published: May 2022

A própolis é uma mistura resinosa natural produzida pelas abelhas a partir de substâncias coletadas de partes de plantas, brotos e exsudatos. Devido à sua natureza cerosa e propriedades mecânicas, as abelhas utilizam a própolis na construção e reparo de suas colméias e tal substância é amplamente conhecida por um efeito benéfico na saúde humana, incluindo a cicatrização de feridas. Nesse contexto, tal pesquisa teve como objetivo abordar, por meio de uma revisão sistemática, o emprego do extrato de própolis na clínica de lesões e da cicatrização de feridas na pele, levando em consideração seus beneficios. A pesquisa consistiu em uma revisão sistemática, com abordagem quantitativa, em que utilizou os descritores “Propolis” OU “Apis mellifera L.” e “Wound Healing”, aplicando ainda o intervalo temporal dos últimos cinco anos. Para a coleta dos dados forma utilizados critérios de inclusão e exclusão citados. Ao se utilizar os descritores e intervalo temporal nas três bases de dados se encontrou no total 378 artigos, que após um processo de filtragem utilizando os critérios de inclusão e exclusão citados anteriormente, um resultado final de onze artigos foram selecionados. Os estudos demonstrados nesta pesquisa apresentam o extrato de própolis como um tratamento promissor na cicatrização da pele levando em consideração o efeito terapêutico de seus constituintes que, de forma eficaz, acelera o processo de reparação tecidual, melhorando significativamente a qualidade de vida aos portadores de lesões.
Effects of Elbow Crutch Locomotion on Gluteus Medius Activation During Stair Ascending
Authors: De la Fuente Carlos , Neira Alejandro , Torres Gustavo , Silvestre Rony , Roby Matias , Yañez Roberto , Herrera Sofia , Martabit Virgina , McKay Isabel , Carpes Felipe P. 
Published: May 2022

Crutches can help with the locomotion of people with walking disorders or functional limitations. However, little is known about hip muscle activation during stair ascending using different crutch locomotion patterns in people without disorders and limitations. Thus, we determined the acute effects of elbow crutch locomotion on gluteus medius (GM) activity during stair ascending. This comparative analytic cross-sectional study enrolled ten healthy men (22.0 ± 0.47 years). Participants climbed up the stairs with elbow crutches using one or two crutches, with ipsilateral or contralateral use, and after loading or unloading a limb. EMG signals were recorded from anterior, middle, and posterior portions of the GM and compared between the crutch conditions. The Kruskal–Wallis test and Dunn’s multiple comparison test were performed (α= 5%). The activation of the GM increased with the ipsilateral use of crutches, with two crutches and three points, and when all the load depended only on one limb. GM activation decreased with contralateral use and in the unload limb. In conclusion, ascending stairs with elbow crutches alters the GM activation. The more critical factors were choosing the crutches’ lateral use, the number of crutches, and if the limb is loaded or unloaded while ascending the stairs. Our findings can be helpful to increase or decrease the GM activation for those who use or will use crutches.
Antagonistic Interaction of Selenium and Cadmium in Human Hepatic Cells Through Selenoproteins
Authors: Ramírez-Acosta S. , Uhlírová R. , Navarro F. , Gómez-Ariza J. L. , García-Barrera T. 
Published: May 2022

Cadmium (Cd) is a highly toxic heavy metal for humans and animals, which is associated with acute hepatotoxicity. Selenium (Se) confers protection against Cd-induced toxicity in cells, diminishing the levels of ROS and increasing the activity of antioxidant selenoproteins such as glutathione peroxidase (GPx). The aim of this study was to evaluate the antagonistic effect of selenomethionine (SeMet) against Cd toxicity in HepG2 cells, through the modulation of selenoproteins. To this end, the cells were cultured in the presence of 100 µM SeMet and 5 μM, 15 µM, and 25 µM CdCl2 and a combination of both species for 24 h. At the end of the experiment, cell viability was determined by MTT assay. The total metal content of Cd and Se was analyzed by triple-quadrupole inductively coupled plasma–mass spectrometry (ICP-QqQ-MS). To quantify the concentration of three selenoproteins [GPx, selenoprotein P (SELENOP), and selenoalbumin (SeAlb)] and selenometabolites, an analytical methodology based on column switching and a species-unspecific isotopic dilution approach using two-dimensional size exclusion and affinity chromatography coupled to ICP-QqQ-MS was applied. The co-exposure of SeMet and Cd in HepG2 cells enhanced the cell viability and diminished the Cd accumulation in cells. Se supplementation increased the levels of selenometabolites, GPx, SELENOP, and SeAlb; however, the presence of Cd resulted in a significant diminution of selenometabolites and SELENOP. These results suggested that SeMet may affect the accumulation of Cd in cells, as well as the suppression of selenoprotein synthesis induced by Cd.
Fast, Simple, and Highly Specific Molecular Detection of Porphyromonas gingivalis Using Isothermal Amplification and Lateral Flow Strip Methods
Authors: Ge Duobao , Wang Fang , Hu Yanyan , Wang Bendi , Gao Xuzhu , Chen Zhenxing 
Published: May 2022

Porphyromonas gingivalis is an important oral pathogen that causes periodontal disease and is difficult to culture under conventional conditions. Therefore, a reliable technique for detecting this pathogenic bacterium is required. Here, isothermal recombinase polymerase amplification (RPA), a new nucleic acid amplification method, was combined with a visualization method based on nanoparticle-based lateral flow strips (LFS) for the rapid detection of P. gingivalis. The species-specific 16S rRNA sequence of P. gingivalis was used as the target for RPA, and a set of specific primer–probe combinations were designed and screened to amplify the target sequences. As a thermostatic amplification method, the RPA reaction, under optimized conditions, takes only 30 min to complete at a constant temperature (37°C). The amplification reaction products can be detected visually by LFS without any need for special equipment. The RPA-LFS method established for the detection of P. gingivalis was shown to be highly specific in distinguishing P. gingivalis from other pathogenic organisms by using 20 clinical isolates of P. gingivalis and 23 common pathogenic microorganisms. Susceptibility measurements and probit regression analysis were performed with gradient dilutions of P. gingivalis genomic DNA. The method was obtained to be highly sensitive, with a detection limit of 9.27 CFU per reaction at 95% probability. By analyzing the gingival sulcus fluid specimens from 130 patients with chronic periodontitis, the results showed that the RPA-LFS method detected 118 positive cases and 12 negative cases of P. gingivalis, and the results obtained were consistent with those of a conventional PCR assay. The RPA–LFS method is an efficient, rapid, and convenient diagnostic method that simplifies the tedious process of detecting P. gingivalis.
The Potential Association of Delayed T Lymphocyte Reconstitution Within Six Months Post-Transplantation With the Risk of Cytomegalovirus Retinitis in Severe Aplastic Anemia Recipients
Authors: Mo Wenjian , Chen Xiangting , Zhang Xu , Wang Shunqing , Li Ling , Zhang Yuehong 
Published: May 2022

BackgroundDelayed immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) is significantly associated with cytomegalovirus (CMV) infection. The aim of this study was to observe the recovery trend of peripheral lymphocyte subsets and immunoglobulins in HSCT recipients who developed CMV retinitis (CMVR).MethodsWe identified 37 CMVR cases and 303 non-CMVR controls in this case-control study from a database of 404 consecutive severe aplastic anemia patients who received allogeneic HSCT at a single center between 2015 and 2020. We analyzed the transplant outcomes and immune reconstitution principles with a focus on lymphocyte CD series and immunoglobulin series within the first year post-HSCT.ResultsThirty-seven patients (55 eyes) were diagnosed with CMVR, with a mean onset time of 155 days post-HSCT. Among the 37 patients, one never had CMV detected in his blood but had a high CMV load in his intraocular fluid at the time of CMVR diagnosis. In the controls, 195 had CMV viremia and 108 did not. Compared with controls, CMVR cases had a longer duration of CMV viremia and a higher peak number of CMV load. T lymphocyte subsets including CD3, CD4 and CD8 were significantly lower in CMVR cases within six months after HSCT (all p &lt; 0.05). Immunoglobulins also showed a slower recovery trend in CMVR cases. The recovery of B lymphocytes and natural killer cells exhibited no significant differences between the two groups.ConclusionsIt is not enough to develop fundus screening strategies by merely relying on the CMV serostatus of recipients. Dynamic and continuous monitoring of T lymphocyte subsets, especially within six months post-HSCT, as well as serum immunoglobulin levels, can provide assistance with screening program of CMVR in HSCT recipients with severe aplastic anemia.
Hemodynamic Changes Before and After Endovascular Treatment of Type B Aortic Dissection by 4D Flow MRI
Authors: Cosset Benoit , Boussel Loic , Davila Serrano Eduardo , Millon Antoine , Douek Philippe , Farhat Fadi , Sigovan Monica 
Published: May 2022

Objective:The standard treatment for complicated Stanford type B aortic dissection (TBAD) is thoracic endovascular aortic repair (TEVAR). Functional parameters, specifically blood flow, are not measured in the clinical assessment of TEVAR, yet they are of outmost importance in patient outcome. Consequently, we investigated the impact of TEVAR on the flows in the aorta and its branches in TBAD using 4D Phase-Contrast Magnetic Resonance Imaging (4D Flow MRI).MethodsSeven patients with TBAD scheduled for TEVAR underwent pre and post-operative 4D Flow MRI. An experienced reader assessed the presence of helical flow in the false lumen (FL) using streamlines and measured net flow at specific locations. In addition, forward and reverse flows, stasis, helicity, and absolute helicity were computed automatically along the aorta centerline. Average values were then computed in the segmented vessels. Impact of TEVAR on these parameters was assessed with a Wilcoxon signed rank test. Impact of the metallic stent on the velocity quantification was assessed using intra-class correlation coefficient (ICC) between velocities measured intra-stent and in adjacent stent-free regions.ResultsFL helical flow was observed proximally in 6 cases and distally in 2 cases pre-operatively. Helical flow disappeared post-TEVAR proximally, but developed distally for 2 patients. Intra-stent measures were similar to stent-free with a median difference of 0.1 L/min and an ICC equal to 0.967 (p &lt; 0.01). Forward flow increased from 59.9 to 81.6% in the TL and significantly decreased in the FL from 15.9 to 3.3%. Similarly, reverse flow increased in the TL from 4.36 to 10.8% and decreased in the FL from 10.3 to 4.6%. No significant changes were observed in net flow for aortic branches (p &gt; 0.05). A significant increase in FL stasis was observed (p = 0.04).DiscussionTEVAR significantly increased forward flow in the TL and significantly decreased both forward and reverse flows in the FL. Interestingly, reverse flow in the TL increased post-TEVAR, which could be due to increased rigidity of the wall, due to the metallic stent. User independent helicity quantification enabled detection of elevated helicity at the level of secondary entry tears which had been missed by streamline visualization.
Genetically Predicted Obesity Causally Increased the Risk of Hypertension Disorders in Pregnancy
Authors: Wang Wenting , Tan Jiang-Shan , Hua Lu , Zhu Shengsong , Lin Hongyun , Wu Yan , Liu Jinping 
Published: May 2022

AimsThis study aimed to evaluate the causal association between obesity and hypertension disorders in pregnancy.MethodsTwo-sample Mendelian randomization (MR) study was conducted based on the data obtained from the GIANT (n = 98,697 participants) consortium and FinnGen (n = 96,449 participants) consortium to determine the causal effect of obesity on the risk of hypertension disorders in pregnancy. Based on a genome-wide significance, 14 single-nucleotide polymorphisms (SNPs) associated with obesity-related databases were used as instrumental variables. The random-effects inverse-variance weighted (IVW) method was adopted as the main analysis with a supplemented sensitive analysis of the MR-Egger and weighted median approaches.ResultsAll three MR methods showed that genetically predicted obesity causally increased the risk of hypertension disorders in pregnancy. IVW analysis provided obesity as a risk factor for hypertension disorders in pregnancy with an odds ratio (OR) of 1.39 [95% confidence interval (CI) 1.21–1.59; P = 2.46 × 10−6]. Weighted median and MR Egger regression also showed directionally similar results [weighted median OR = 1.49 (95% CI, 1.24–1.79), P = 2.45 × 10−5; MR-Egger OR = 1.95 (95% CI, 1.35–2.82), P = 3.84 × 10−3]. No directional pleiotropic effects were found between obesity and hypertension disorders in pregnancy with both MR-Egger intercepts and funnel plots.ConclusionsOur findings provided directed evidence that obesity was causally associated with a higher risk of hypertension disorders in pregnancy. Taking measures to reduce the proportion of obesity may help reduce the incidence of hypertension disorders in pregnancy.
Spatial Distribution and Evolution of Ancient Settlements From the Neolithic to the Bronze Age in Dalian Area, China
Authors: Liu Liang , Liu Fangfang , Zhang Wei , Xu Zhaofeng 
Published: May 2022

The research on the spatial distribution and evolution of ancient settlements from the Neolithic Age to the Bronze Age in Dalian area is of great significance for a profound understanding of the prehistoric human-land relationship in Dalian area. The results showed that: ① The number of settlement sites in Dalian area showed an overall upward trend from the Mid-Neolithic to the Bronze Age. Most sites during the three periods studied were to be found 0–50 m above sea level (asl), with a significant increase in the number of sites located &gt;50 m asl during the Bronze Age. In terms of gradient of slope, all settlements were concentrated on coastal plains or in low-altitude, hilly areas on relatively gentle slopes ranging between 0 and 6°. Settlements from each period faced in all directions, and were mainly located in river valleys or low-altitude mountain valleys with low terrains.② The proximity of ancient settlements to river courses during the Mid Holocene evolved, with Mid and Late Neolithic settlements usually distributed in the range beyond 3 km of the river buffer zone; the distribution of Bronze Age sites was relatively uniform, reflecting an increasing demand for water resources; the density of settlements was clustered between the Mid Neolithic and the Bronze Age, Neolithic sites being both the smallest in number and the most concentrated. ③ The spatiotemporal distribution and evolution of settlements in the Dalian area were influenced by the contemporary climate: the Mid Neolithic climate was warm and humid, and settlements were distributed principally on the various islands near present-day Dalian, and especially Guanglu Island; the Late Neolithic climate became increasingly drier and cooler, stimulating cultural advances and a slight increase in the number of ancient settlements, which gradually developed in the areas in and around present-day Dalian; during the cold and dry Bronze Age, the number of settlements across the Dalian region reached their peak, and it is widely distributed in various areas of Dalian. To a certain extent, this reflected a continuous improvement in the ability of the human population to adapt to the natural environment.
Significantly Improved Energy Storage Density of Polypropylene Nanocomposites via Macroscopic and Mesoscopic Structure Designs
Authors: Ji Minzun , Min Daomin , Wu Qingzhou , Mi Rui , Liu Wenfeng , Li Shengtao , Qin Shaorui , Zhu Shenglong 
Published: May 2022

Polymer dielectrics with high breakdown strength are very competitively used in the dielectric capacitor, which is widely applied in pulsed power devices and power systems due to their ultra-high power density. The polypropylene (PP) film is the most popularly used polymer for the dielectric capacitor in the market. However, its low energy density cannot meet the emerging demand for miniaturized, compact, and high-energy performance dielectrics. Therefore, it is urgent to raise the energy storage density of the polypropylene film. Here, this study described the improved energy storage density of polypropylene nanocomposites via macroscopic and mesoscopic structure designs. The ABA-structured, BAB-structured, and single-layered nanocomposites were prepared by melting blending and hot-pressing methods, where “A” and “B” films refer to PP/MgO and PP/BaTO3 nanocomposite dielectrics, respectively. Then, the microstructure, dielectric, breakdown, and energy storage properties of these nanocomposite dielectrics were tested. According to the test results, for the sandwich-structured dielectrics, the B layer and the interface between adjacent layers can increase the polarization, and the A layer and the barrier at the interface can reduce the charge mobility. In addition, the sandwich structures can redistribute the electric field. Correspondingly, the breakdown strength and permittivity of PP dielectrics are improved synergistically. Compared to the PP nanocomposite dielectrics with the BAB structure, the dielectric with the ABA structure exhibits more excellent energy storage performance. The largest energy storage density of ABA films with a BaTO3 content of 45 wt% in the B layer is 3.10 J/cm3, which is 67% higher than that of pure PP. The study provides a new concept for improving the energy storage performance of polymer nanocomposite dielectrics from the perspective of macroscopic and mesoscopic structure designs.