bluuebunny/crossref_metadata_2025_split huggingface dataset:
La música como agente de territorialidades y devenires. Un enfoque desde Gilles Deleuze
Authors:   , Díaz Leguizamón Juan Manuel 
Published: July 2022

La tesis se inscribe en la corriente geoestética, que toma en consideración la importancia de nociones espaciales y de producción territorial en el pensamiento deleuziano. Dentro de un enfoque en el que el arte tiene la capacidad de capturar fuerzas generativas y creativas de la naturaleza, la música aparece con un estatuto especial, siendo su función principal la desterritorialización del ritornelo, abrir líneas de fuga dentro de lo formado y sedimentado, haciendo disponibles inmensos poderes de resistencia, rebeldía e invención al margen de los poderes instituidos. Para Deleuze, la música que logra liberarse de las sujeciones mayoritarias que bloquean lo nuevo se encuentra dentro de expresiones vanguardistas "modernas", pero el problema es que la música popular difícilmente podría, por sí misma, hacer algo diferente a reforzar el ritornelo con sus nociones "clásicas" o "románticas" de forma, materia, significación, subjetividad, y sus dimensiones extra-artísticas concomitantes: modelos sociales, políticos y económicos de explotación y control, un "modelo trabajo", ligado a una metafísica de la trascendencia. A través de la historia de la población afroamericana en EE.UU., el blues y especialmente el fenómeno de "imitación de trenes en armónica", se explora cómo la música popular permite de manera inesperada operaciones minoritarias cercanas a la noción de "arte moderno": atendiendo más bien a un "modelo de acción libre", invocan fuerzas que se liberan de los criterios jerárquicos de forma, tiempo, tono, ritmo, etc., agenciando a su paso líneas de fuga, devenires, individuaciones paradójicas y bloques de sensación, ligados a una ontología de la inmanencia.
La imagen del hombre en el malestar en la cultura de Sigmund Freud
Authors:   , Sampedro Vanegas Henry Diego Fernando 
Published: July 2022

Evadiendo la lectura de sus textos, el pensamiento de Freud se considera caduco en muchos círculos académicos. Se arguye que sus discípulos han superado con creces los planteamientos y han renovado "el psicoanálisis". El presente ensayo trata de hacer una lectura cuidadosa de El malestar en la cultura, atendiendo a sus giros teóricos, a la precisión de los términos usados, a la unidad del conocimiento que se evidencia en el uso de referencias médicas, psicológicas, antropológicas y poéticas, a una misma vez. Pero sobretodo, en respuesta a la necesidad de partir de los sentimientos humanos, de tratar de encontrar las fuentes que subyacen en algunas de las más cotidianas y comunes sensaciones humanas. La sola lectura cuidadosa permite una actualización del texto, quizá por el hecho de librarnos de los prejuicios. La cultura es vista como la técnica para sobrevivir propia de la criatura humana, un método en el que permanecen en constante tensión dos proto - instintos, uno de conservación (Eros) y uno de autodestrucción (Muerte). Esta lucha se produce tanto en la psique como en la especie, pues los límites entre individuo y cultura son difusos. La relativa preservación de la especie se ha producido a merced del deseo. La renuncia a la satisfacción instintual es condición de todo proceso cultural por lo que se percibe una generalizada sensación de malestar hacia la cultura. Todos estamos enfermos de civilización. Desantropologizado, el hombre no es más que una criatura que lucha por sobrevivir.
Inestabilidad constitutiva como horizonte de la vivencia frágil
Authors:   , Ramírez Giraldo Juan Pablo 
Published: July 2022

El presente estudio titulado "Inestabilidad constitutiva como horizonte de la vivencia frágil" puede caracterizarse, en forma general, como una reflexión filosófica preocupada por la fragilidad de la condición humana, es decir, puede definirse como una reflexión filosófica que sabe que debe volver sobre la estructura intencional del obrar, no solamente con el ánimo de comprender el origen, los límites y las condiciones de realización del mal, sino con el objetivo de poner en evidencia el valor originario y las implicaciones que tiene para la vida del hombre la posibilidad de fallar. Dicho de otro modo, lo que caracteriza este estudio es su compromiso con una idea de inestabilidad constitutiva o de fragilidad ontológica capaz de ponerse, en primer lugar, como horizonte de comprensión del fallar y del mal y, en segundo lugar, como coordenada que permitirá -en el caso de este estudio- elaborar, en forma general, algunos presupuestos proyectivos que puedan guiar la elaboración de una ética de la falibilidad fundada en la idea de inestabilidad como horizonte de todo obrar.
The Case for Waste to Energy
Authors: Castaldi Marco J. , LeBlanc Jeff , Licata Anthony 
Published: July 2022

Abstract
There is a better way of handling MSW that is not or cannot be recycled: thermal conversion, also called waste to energy. These facilities feed waste into a combustion chamber with air and incinerate it. The heat released from combustion produces steam for use in a district heat network, or to generate electricity, or do both in combined heat and power systems. In addition to enabling the heat content of the MSW to be recovered, combustion reduces its final volume by more than 90 percent, thus decreasing the need for landfills.
Living through the psychological consequences of COVID-19 pandemic: a systematic review of effective mitigating interventions
Authors: Lekagul Angkana , Piancharoen Peeraya , Chattong Anamika , Suradom Chawisa , Tangcharoensathien Viroj 
Published: July 2022

ObjectiveThis review assesses interventions and their effectiveness in mitigating psychological consequences from pandemic.MethodPublished English literatures were searched from four databases (Medline, PubMed, Embase and PsycINFO) from January 2020 and September 2021. A total of 27 papers with 29 studies (one paper reported three studies) met inclusion criteria. Cochrane risk-of-bias tool is applied to assess the quality of all randomised controlled trials (RCT).ResultsAll studies were recently conducted in 2020. Publications were from high-income (13, 44.8%), upper middle-income (12, 41.4%) and lower middle-income countries (3, 10.3%) and global (1, 3.5%). Half of the studies conducted for general population (51.7%). One-third of studies (8, 27.6%) provided interventions to patients with COVID-19 and 20.7% to healthcare workers. Of the 29 studies, 14 (48.3%) were RCT. All RCTs were assessed for risk of biases; five studies (15, 35.7%) had low risk as measured against all six dimensions reflecting high-quality study.Of these 29 studies, 26 diagnostic or screening measures were applied; 8 (30.9%) for anxiety, 7 (26.9%) for depression, 5 (19.2%) for stress, 5 (19.2%) for insomnia and 1 (3.8%) for suicide. Measures used to assess the baseline and outcomes of interventions were standardised and widely applied by other studies with high level of reliability and validity. Of 11 RCT studies, 10 (90.9%) showed that anxiety interventions significantly lowered anxiety in intervention groups. Five of the six RCT studies (83.3%) had significantly reduced the level of depression. Most interventions for anxiety and stress were mindfulness and meditation based.ConclusionsResults from RCT studies (11%, 78.6%) were effective in mitigating psychological consequences from COVID-19 pandemic when applied to healthcare workers, patients with COVID-19 and general population. These effective interventions can be applied and scaled up in other country settings through adaptation of modes of delivery suitable to country resources, pandemic and health system context.
Digital multiple health behaviour change intervention targeting online help seekers: protocol for the COACH randomised factorial trial
Authors: Åsberg Katarina , Blomqvist Jenny , Lundgren Oskar , Henriksson Hanna , Henriksson Pontus , Bendtsen Preben , Löf Marie , Bendtsen Marcus 
Published: July 2022

IntroductionUnhealthy lifestyle behaviours continue to be highly prevalent, including alcohol consumption, unhealthy diets, insufficient physical activity and smoking. There is a lack of effective interventions which have a large enough reach into the community to improve public health. Additionally, the common co-occurrence of multiple unhealthy behaviours demands investigation of efforts which address more than single behaviours.Methods and analysisThe effects of six components of a novel digital multiple health behaviour change intervention on alcohol consumption, diet, physical activity and smoking (coprimary outcomes) will be estimated in a factorial randomised trial. The components are designed to facilitate behaviour change, for example, through goal setting or increasing motivation, and are either present or absent depending on allocation (ie, six factors with two levels each). The study population will be those seeking help online, recruited through search engines, social media and lifestyle-related websites. Included will be those who are at least 18 years of age and have at least one unhealthy behaviour. An adaptive design will be used to periodically make decisions to continue or stop recruitment, with simulations suggesting a final sample size between 1500 and 2500 participants. Multilevel regression models will be used to analyse behavioural outcomes collected at 2 months and 4 months postrandomisation.Ethics and disseminationApproved by the Swedish Ethical Review Authority on 2021-08-11 (Dnr 2021-02855). Since participation is likely motivated by gaining access to novel support, the main concern is demotivation and opportunity cost if the intervention is found to only exert small effects. Recruitment began on 19 October 2021, with an anticipated recruitment period of 12 months.Trial registration numberISRCTN16420548.
CRISPR-mediated TGFBR2 knockout renders human ovarian cancer tumor-infiltrating lymphocytes resistant to TGF-β signaling
Authors: Fix Samantha M , Forget Marie-Andrée , Sakellariou-Thompson Donastas , Wang Yunfei , Griffiths Tamara M , Lee Minjung , Haymaker Cara L , Dominguez Ana Lucía , Basar Rafet , Reyes Christopher , Kumar Sanjay , Meyer Larissa A , Hwu Patrick , Bernatchez Chantale , Jazaeri Amir A 
Published: July 2022

BackgroundThe correlation between elevated T-cell infiltration and improved survival of ovarian cancer (OvCa) patients suggests that endogenous tumor-infiltrating lymphocytes (TIL) possess some degree of antitumor activity that can be harnessed for OvCa immunotherapy. We previously optimized a protocol for ex vivo OvCa TIL expansion for adoptive cell therapy, which is now being tested in a clinical trial at our institution (NCT03610490). Building on this success, we embarked on genetic modification of OvCa TIL to overcome key immunosuppressive factors present in the tumor microenvironment. Here, we present the preclinical optimization of CRISPR/Cas9-mediated knockout of the TGF-β receptor 2 (TGFBR2) in patient-derived OvCa TIL.MethodsOvCa TILs were generated from four patients’ tumor samples obtained at surgical resection and subjected to CRISPR/Cas9-mediated knockout of TGFBR2 before undergoing a rapid expansion protocol. TGFBR2-directed gRNAs were comprehensively evaluated for their TGFBR2 knockout efficiency and off-target activity. Furthermore, the impact of TGFBR2 knockout on TIL expansion, function, and downstream signaling was assayed.ResultsTGFBR2 knockout efficiencies ranging from 59±6% to 100%±0% were achieved using 5 gRNAs tested in four independent OvCa TIL samples. TGFBR2 knockout TIL were resistant to immunosuppressive TGF-β signaling as evidenced by a lack of SMAD phosphorylation, a lack of global transcriptional changes in response to TGF-β stimulation, equally strong secretion of proinflammatory cytokines in the presence and absence of TGF-β, and improved cytotoxicity in the presence of TGF-β. CRISPR-modification itself did not alter the ex vivo expansion efficiency, immunophenotype, nor the TCR clonal diversity of OvCa TIL. Importantly for clinical translation, comprehensive analysis of CRISPR off-target effects revealed no evidence of off-target activity for our top two TGFBR2-targeting gRNAs.ConclusionsCRISPR/Cas9-mediated gene knockout is feasible and efficient in patient-derived OvCa TIL using clinically-scalable methods. We achieved efficient and specific TGFBR2 knockout, yielding an expanded OvCa TIL product that was resistant to the immunosuppressive effects of TGF-β. This study lays the groundwork for clinical translation of CRISPR-modified TIL, providing opportunities for engineering more potent TIL therapies not only for OvCa treatment, but for the treatment of other solid cancers as well.
Acute pain consult and management is associated with improved mortality in rib fracture patients
Authors: Sborov Katherine D , Dennis Bradley M , de Oliveira Filho Getúlio Rodrigues , Bellister Seth A , Statzer Nicholas , Stonko David P , Guyer Richard A , Wanderer Jonathan P , Beyene Robel T , McEvoy Matthew D , Allen Brian Frazer Scott 
Published: July 2022

IntroductionTraumatic rib fractures result in significant patient morbidity and mortality, which increases with patient age and number of rib fractures. A dedicated acute pain service (APS) providing expertize in multimodal pain management may reduce these risks and improve outcomes. We aimed to test the hypothesis that protocolized APS consultation decreases mortality and morbidity in traumatic rib fracture patients.MethodsThis is a retrospective observational, propensity-matched cohort study of adult patients with trauma with rib fractures from 2012 to 2015, at a single, large level 1 trauma center corresponding to introduction and incorporation of APS consultation into the institutional rib fracture pathway. Using electronic medical records and trauma registry data, we identified adult patients presenting with traumatic rib fractures. Patients with hospital length of stay (LOS) ≥2 days were split into two cohorts based on presence of APS consult using 1:1 propensity matching of age, gender, comorbidities and injury severity. The primary outcome was difference in hospital mortality. Secondary outcomes included LOS and pulmonary morbidity.Results2486 patients were identified, with a final matched cohort of 621 patients receiving APS consult and 621 control patients. The mortality rate was 1.8% among consult patients and 6.6% among control patients (adjusted OR 0.25, 95% CI 0.13 to 0.50; p=0.001). The average treatment effect of consult on mortality was 4.8% (95% CI 1.2% to 8.5%;. p<0.001). APS consultation was associated with increased intensive care unit (ICU) LOS (1.19 day; 95% CI 0.48 to 1.90; p=0.001) and hospital LOS (1.61 days; 95% CI 0.81 to 2.41 days; p<0.001). No difference in pulmonary complications was observed.DiscussionAn APS consult in rib fracture patients is associated with decreased mortality and no difference in pulmonary complications yet increased ICU and hospital LOS.
Geology, geochemistry, and apatite/titanite U–Pb geochronology of ca. 1.88 Ga alkaline ultrabasic dykes in the Southern Province near Sudbury, Ontario
Authors: Kawohl Alexander , Frimmel Hartwig E. , Whymark Wesley E. , Millonig Leo J. , Gerdes Axel 
Published: July 2022

The area northeast of Sudbury, Ontario, is well known for hosting one of the largest unexplained geophysical anomalies in the Canadian Shield, the Temagami Anomaly. In search of a geological explanation for this anomaly, low-grade metamorphic ultrabasic dykes have been discovered in the overlying Huronian Supergroup sedimentary rocks, both in outcrop and in a deep drill core. Here, we report on the first geochemical and geochronological data obtained on these dykes and compare these data with known magmatic units in and around the 1850 Ma impact-generated Sudbury Igneous Complex (SIC). The NW-striking dykes, which cut across sedimentary rocks of the ca. 2.3 Ga Cobalt Group, and which are, in turn, crosscut by pseudotachylitic breccia, are characterized by distinctively high concentrations of Ti, P, Nb, and Zr, highly fractionated rare earth element patterns (La/YbN 7.6–15.5), and a lack of crustal contamination (Nb/Th > 10). Such features are typical of modern ocean island basalts but very different from Palaeoproterozoic rocks previously documented in the wider region. Multigrain U–Pb laser ablation inductively coupled plasma mass spectrometry analyses performed on magmatic titanite and apatite with high Th/U ratios yielded 1876.0 ± 8.7 and 1880.9 ± 8.3 Ma, respectively, which we interpret as the intrusion age of the dykes. This interpretation is supported by similar whole-rock Sm-Nd model ages of 1890–2000 Ma (initial εNd +2.5). This magmatic event in the footwall of the SIC shortly before the impact was coeval with, and likely genetically related to, the 1.88–1.87 Ga Circum-Superior Large Igneous Province.
A description of charmonia decays $$J/\psi \rightarrow B\bar{B}$$ within the QCD factorisation framework
Authors: Kivel Nikolay 
Published: July 2022

AbstractDecays $$J/\psi \rightarrow B{\bar{B}}$$

J
/
ψ
→
B

B

¯

into octet baryon-antibaryons pairs are studied within the QCD factorisation framework. The next-to-leading power correction to the leading-order decay amplitude is calculated for the first time. The phenomenological analysis also includes the interference with the electromagnetic decay $$J/\psi \rightarrow \gamma ^*\rightarrow B{\bar{B}}$$

J
/
ψ
→

γ
∗

→
B

B

¯

. The branching fractions and the angular coefficients $$\alpha _B$$

α
B

are obtained with an accuracy of about $$20\%$$

20
%

. The obtained results allow us to conclude that the calculated amplitudes provide a dominant contribution and therefore QCD factorisation provides a suitable basis for understanding of these decays.
Delta-resonances and hyperons in proto-neutron stars and merger remnants
Authors: Sedrakian Armen , Harutyunyan Arus 
Published: July 2022

AbstractThe equation of state (EoS) and composition of dense and hot $$\varDelta $$
Δ
-resonance admixed hypernuclear matter is studied under conditions that are characteristic of neutron star binary merger remnants and supernovas. The cold, neutrino free regime is also considered as a reference for the astrophysical constraints on the EoS of dense matter. Our formalism uses the covariant density functional (CDF) theory successfully adapted to include the full $$J^P=1/2^+$$

J
P

=
1
/

2
+

baryon octet and non-strange members of $$J^P=3/2^+$$

J
P

=
3
/

2
+

decouplet with density-dependent couplings that have been suitably adjusted to the existing laboratory and astrophysical data. The effect of $$\varDelta $$
Δ
-resonances at finite temperatures is to soften the EoS of hypernuclear matter at intermediate densities and stiffen it at high densities. At low temperatures, the heavy baryons $$\varLambda $$
Λ
, $$\varDelta ^-$$

Δ
-

, $$\varXi ^-$$

Ξ
-

, $$\varXi ^0$$

Ξ
0

and $$\varDelta ^0$$

Δ
0

appear in the given order if the $$\varDelta $$
Δ
-meson couplings are close to those for the nucleon-meson couplings. As is the case for hyperons, the thresholds of $$\varDelta $$
Δ
-resonances move to lower densities with the increase of temperature indicating a significant fraction of $$\varDelta $$
Δ
’s in the low-density subnuclear regime. We find that the $$\varDelta $$
Δ
-resonances comprise a significant fraction of baryonic matter, of the order of $$10\%$$

10
%

at temperatures of the order of several tens of MeV in the neutrino-trapped regime and, thus, may affect the supernova and binary neutron star dynamics by providing, for example, a new source for neutrino opacity or a new channel for bulk viscosity via the direct Urca processes. The mass-radius relation of isentropic static, spherically symmetric hot compact stars is discussed.
Design and Validation of Inducible TurboCARs with Tunable Induction and Combinatorial Cytokine Signaling
Authors: Lin Regina J. , Nager Andrew R. , Park Spencer , Sutton Janette , Lay Cecilia , Melton Zea , Zhang Yi , Boldajipour Bijan , Blarcom Thomas J. Van , Panowski Siler H. , Sasu Barbra J. , Chaparro-Riggers Javier 
Published: July 2022

AbstractAlthough cytokine support can enhance CAR T-cell function, coadministering cytokines or engineering CAR T cells to secrete cytokines can result in toxicities. To mitigate these safety risks, we engineered iTurboCAR T cells that coexpress a novel inducible Turbo (iTurbo) cytokine signaling domain. iTurbo domains consist of modular components that are customizable to a variety of activating inputs, as well as cytokine signaling outputs multiplexable for combinatorial signaling outcomes. Unlike most canonical cytokine receptors that are heterodimeric, iTurbo domains leverage a compact, homodimeric design that minimizes viral vector cargo. Using an iTurbo domain activated by the clinically validated dimerizer, AP1903, homodimeric iTurbo domains instigated signaling that mimicked the endogenous heterodimeric cytokine receptor. Different iTurbo domains programmed iTurboCAR T cells toward divergent phenotypes and resulted in improved antitumor efficacy. iTurbo domains, therefore, offer the flexibility for user-programmable signaling outputs, permitting control over cellular phenotype and function while minimizing viral cargo footprint.
Gastric Microbiome Alterations Are Associated with Decreased CD8+ Tissue-Resident Memory T Cells in the Tumor Microenvironment of Gastric Cancer
Authors: Peng Rui , Liu Shuai , You Wenhua , Huang Yedi , Hu Chupeng , Gao Ye , Jia Xuemei , Li Gang , Xu Zekuan , Chen Yun 
Published: July 2022

Abstract
The host microbiota is closely associated with tumor initiation and progression in multiple solid tumors including gastric cancer. The aim of this study was to investigate in patients with gastric cancer whether there are alterations in gastric microbiota and any potential association these may have with immune dysregulation. 16S rRNA gene sequencing was used to analyze tumor microbiota of 53 patients with gastric cancer and gastric mucosal tissue microbiota of 30 patients with chronic gastritis. The effect of microbiota on the tumor microenvironment (TME) was studied by single-cell sequencing, immunohistochemistry, multiplex immunofluorescence staining, and flow cytometry, as well as in a mouse model of primary gastric cancer. The gastric cancer microbiota was characterized by reduced microbial diversity and enrichment of the Oceanobacter, Methylobacterium, and Syntrophomonas genera. Intratumoral Methylobacterium was significantly associated with poor prognoses in patients with gastric cancer. It also was inversely correlated with the frequency of CD8+ tissue-resident memory T (TRM) cells in the TME. TGFβ was significantly reduced in gastric cancer samples with higher abundance of Methylobacterium. Finally, we verified that Methylobacterium can decrease TGFβ expression and CD8+ TRM cells in the tumor by establishing a mouse model of primary gastric cancer. The results suggest that tumor microbiota and exhausted CD8+ TRM cells in the TME of gastric cancer are significantly correlated, and that Methylobacterium may play a role in gastric carcinogenesis.