bluuebunny/crossref_metadata_2025_split huggingface dataset:
MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma
Authors: Yen Wei-Chen , Chang Kai-Ping , Chen Cheng-Yi , Huang Yenlin , Chen Ting-Wen , Cheng Hsing-Wen , Yi Jui-Shan , Cheng Chun-Chia , Wu Chih-Ching , Wang Chun-I 
Published: November 2022

Abstract
Oral squamous cell carcinoma (OSCC) is the predominant histological type of the head and neck squamous cell carcinoma (HNSCC). By comparing the differentially expressed genes (DEGs) in OSCC-TCGA patients with copy number variations (CNVs) that we identify in OSCC-OncoScan dataset, we herein identified 37 dysregulated candidate genes. Among these potential candidate genes, 26 have been previously reported as dysregulated proteins or genes in HNSCC. Among 11 novel candidates, the overall survival analysis revealed that melanotransferrin (MFI2) is the most significant prognostic molecular in OSCC-TCGA patients. Another independent Taiwanese cohort confirmed that higher MFI2 transcript levels were significantly associated with poor prognosis. Mechanistically, we found that knockdown of MFI2 reduced cell viability, migration and invasion via modulating EGF/FAK signaling in OSCC cells. Collectively, our results support a mechanistic understanding of a novel role for MFI2 in promoting cell invasiveness in OSCC.
Adsorption of radon on silver exchanged zeolites at ambient temperatures
Authors: Heinitz Stephan , Mermans Jasper , Maertens Dominic , Skliarova Hanna , Aerts Alexander , Cardinaels Thomas , Rutten Jos , Gueibe Christophe , Kuznicki Daniel , Ireland Natalie , Kuznicki Steven 
Published: November 2022

Abstract
Since more than 100 years, the adsorption of the radioactive noble gas radon (222Rn) is performed on activated charcoal at cryogenic temperatures. There is little – if any – progress in the field of radon adsorption at ambient conditions to facilitate the development of simple and compact radon adsorption systems. We report here on the truly remarkable property of the synthetic silver-exchanged zeolites Ag-ETS-10 and Ag-ZSM-5 to strongly adsorb radon gas at room temperature. 222Rn breakthrough experiments in nitrogen carrier gas have shown that these materials exhibit radon adsorption coefficients exceeding 3,000 m3/kg at 293 K, more than two orders of magnitude larger than any noble gas adsorbent known to date. Water vapor and carrier gas type were found to strongly influence radon adsorption, practically qualifying these silver exchanged materials as a new class of radon adsorbents. Our results demonstrate that Ag-ETS-10 and Ag-ZSM-5 are materials that show high affinity towards radon gas at ambient temperatures making them candidate materials for environmental and industrial 222Rn mitigation applications. Adsorption systems based on silver loaded zeolites have the potential to replace activated charcoal as material of choice in many radon related research areas by avoiding the necessity of cryogenic cooling.
SPOCD1 accelerates colorectal cancer by increasing the expression of YAP
Authors: Fu Mingyue , Yuan Yifan , Mao Yujuan , Zhu Hua , Ye Mei 
Published: November 2022

Abstract
Colorectal cancer (CRC) is a global disease, it is of great significance to discover a novel target for the treatment of CRC. SPOCD1 encodes proteins belonging to the transcription factor S-II (TFIIS) transcription factor family. The expression of SPOCD1 increases in a variety of tumor types, including ovarian cancer, osteosarcoma, glioblastoma, sophageal squamous cell carcinoma, and so on. In this study, we detected the expression of SPOCD1 in CRC tissues and cells. We also evaluated the correlation between the prognosis of CRC and the expression of SPOCD1 and found SPOCD1 was overexpressed in CRC and correlated with a poor prognosis. Meanwhile, the correlations between SPOCD1 expression and drugs were evaluated as well. We observed the genetic alteration status of SPOCD1 in CRC. Immune cell infiltration showed that there is a positive correlation between SPOCD1 expression and immune function. In vitro, SPOCD1 could promote CRC cell proliferation and migration. In the meantime, apoptosis was inhibited. YAP was identified as the target gene of SPOCD1 via qRT-PCR and western blot. Compared to only transfecting siSPOCD1, the proliferation of HT29 cells was partially restored when co-transfected with siSPOCD1 and oeYAP.
Background: CRC is a common digestive tract tumor with the highest incidence in the world. SPOCD1 is a novel gene that encodes proteins belonging to the transcription factor S-II (TFIIS) transcription factor family. Up to now, whether SPOCD1 contributes the pathegenesis of CRC has been poorly defined. The main purpose of our research was to find the association between SPOCD1 and CRC.
Methods: We used CRC datasets from the tumor immune estimation resource, version 2 (TIMER2) database, and immune cell infiltration was created to investigate immune cell dysregulation in CRC. Western blot was used to detect the expression of SPOCD1 in CRC and non-cancerous tissue. The expression of SPOCD1 in CRC cells was detected by real-time polymerase chain reaction and western blot. Cell Counting Kit 8 and colony formation assay analysis were conducted to analyze the effect of SPOCD1 on cell proliferation. And cell migration was analyzed by scratch assay. Using apoptotic proteins to assess the apoptotic capacity of cells. The protein expression of SPOCD1 and YAP in CRC cells was measured by Western blot.
Results: SPOCD1 was overexpressed in CRC and correlated with a poor prognosis. The higher the expression of SPOCD1, the shorter the survival rate. The expression of SPOCD1 is increased in colorectal cancer cells such as HT29 and SW480 cells. What’s more, the reduction of SPOCD1 inhibits the proliferation and migration of HT29 and SW480 cells and increases apoptosis in HT29 and SW480 cells. And the Hippo/YAP pathway was inhibited by the knockdown of SPOCD1 in HT29 and SW480 cells.
Conclusion: Our study suggests that SPOCD1 may play an oncogenic role by activating the Hippo/YAP pathway to inhibit apoptosis in CRC and can be a potential target for the treatment of CRC.
Experimental and numerical investigation on temperature field and joints tensile failure for CF/PPS-Al alloy interlocking induction welding
Authors: Qin Xuda , Wang Chenyue , Li Hao , Meng Xianming , Yu Tian , Liu Haitao 
Published: November 2022

Abstract
The induction welding has been recognized as one of potential and high-efficiency joining methods for thermoplastic composite materials. In this study, a numerical simulation model with containing both induction wielding heat transfer and joint tensile failure process for CF/PPS-Al alloy interlocking induction welding was established based on software COMSOL Mulitiphysics and Abaqus/Explicit. The CF/PPS-Al7075 interlocking welding joints with special designed macro-scale interlocking were tested under tensile loads, and the corresponding single lap-shear strength, energy absorption and failure mechanisms were investigated by combining the experimental and numerical approaches. Finally, the influence of macro-scale interlocking geometric parameters on joint tensile strength was also discussed. The results indicate that the proposed model can effectively predict the temperature distribution in the welding process and the tensile failure process of the joint. It is also presented that the addition of macro-scale interlocking features can effectively improve the ultimate load (47%) and energy absorption capacity (48%) of the CF/PPS-Al alloy induction welded joints. Meanwhile, the number of addition PPS films in the welding zone and the inclination angle have greater contribution on the tensile strength of the welded joints.
WITHDRAWN: Acute cerebral infarction patients' 3-month mortality predicted by peripheral tumor necrosis factor alpha-induced protein 3 mRNA level
Authors: Huang Nana , Zhang Feng , Zhu Tianrui , Wang Dong , Zhao Yanxin , Li Yanshuang , Wang Min , Zhang Guitao , He Yi , Zhang Yue , Zhang Qingchen , Li Zhichao , Tang Xiaosan , Zhang Yuanyuan , Li Xiaohong 
Published: November 2022

Abstract
Background
Tumor necrosis factor-induced protein 3 (A20) is a novel negative regulator of immunological homeostasis. This research aimed to determine whether A20 mRNA in peripheral blood mononuclear cells (PBMCs) could be used to predict 3-month functional outcome and mortality in individuals with acute cerebral infarction (ACI).
Methods
There were 50 healthy controls and 182 patients with ACI in this study. Real-time quantitative polymerase chain reaction was performed to detect the A20 mRNA expression levels in PBMCs from ACI patients and healthy controls.We also recorded the medical history, score of National Institutes of Health Stroke Scale score on the first day of disease onset (NIHSS1), cranial magnetic resonance imaging findings, and hematological examination index. On day 90 after disease onset, the prognosis was evaluated using a modified Rankin scale.
Results
In comparison to healthy controls, the median A20 mRNA levels in PBMCs of ACI patients were considerably greater (P < 0.001). A20 mRNA expression levels in PBMCs were negatively correlated with lesion volume (r = -0.1678, P < 0.05) and NIHSS1 score (r = -0.2897, P < 0.0001). A20 mRNA expression levels were substantially greater in the survivor group and the groups with favorable outcomes, respectively compared to those in the non-survivor group (P < 0.005) and the groups with unfavorable outcome (P < 0.05).
Conclusion
A20 mRNA is involved in the immune response in ACI and might be a potential biomarker of ACI-related mortality.
Nuclear Respiratory Factor 1 Promotes the Progression of EBV-associated Gastric Cancer and Maintains EBV Latent Infection
Authors: Liang Yue , Liu Wen , Zhao Menghe , Shi Duo , Zhang Yan , Luo Bing 
Published: November 2022

Abstract
Objective
This study aimed to investigate the association of Epstein-Barr virus (EBV) with nuclear respiratory factor 1 (NRF1) and the biological function of NRF1 in EBV-associated gastric cancer (EBVaGC).
Methods
Western blot and qRT-PCR were used to assess the effect of latent membrane protein 2A (LMP2A) on NRF1 expression after transfection with LMP2A plasmid or siLMP2A. The effects of NRF1 on the migration and apoptosis ability of GC cells were investigated by transwell assay and flow cytometry apoptosis analysis in vitro, respectively. In addition, we determined the regulatory role of NRF1 in EBV latent infection by western blot and droplet digital PCR (ddPCR).
Results
LMP2A upregulated NRF1 expression by activating the NF-κB pathway. Moreover, NRF1 upregulated the expression of N-Cadherin and ZEB1 to promote cell migration. NRF1 promoted the expression of Bcl-2 to increase the anti-apoptosis ability of cells. In addition, NRF1 maintained latent infection of EBV by promoting the expression of the latent protein Epstein-Barr nuclear antigen 1 (EBNA1) and inhibiting the expression of the lytic proteins.
Conclusions
Our data indicated the role of NRF1 in EBVaGC progression and the maintenance of EBV latent infection. This provided a new theoretical basis for further NRF1-based anti-cancer therapy.
Application of Miedema’s model for the Calculation of thermodynamic properties of Fe-Al-Cr and Fe-Al-Cu ternary systems
Authors: Alsaedi Ali Kadhim , Mraity Hussien Abid Ali Bakir , Al-Temimei Faeq 
Published: November 2022

Abstract
The model of Miedema semi-empirical can be considered as a promising technique for the estimation of the thermodynamic variables of solid solution that classified into binary and ternary Fe-Al-Cr and Fe-Al-Cu based systems. For the latter to be conducted, A recently delevolped software called MAAT (materials Analysis Applying Thermodynamics ) was used in the current work to calculate the thermodynamic characteristics of the "binary and ternary" systems. The results demonstrated that the values of the Gibbs free energy concerning the binary systems of the solid solution of each of Fe-Al, Fe-Cr, Al-Cr, and Al-Cu were seen to be negative and lower than that of the ideal Gibbs free energy, except with Fe-Cu that was positive. For ternary system (Fe-Al-Cr and Fe-Al-Cu), the Gibbs free energy level were noticed to be negative across most of the composition extent. This is suggesting that, there were driving forces to reach the solid solution from pure Fe, Al, Cr and Cu powders lies within the full extent of composition.
Blood-brain barrier rescue by roflumilast after transient global cerebral ischemia in rats
Authors: Bonato Jéssica Mendes , Mattos Bianca Andretto , Oliveira Daniela Velasquez , Milani Humberto , Prickaerts Jos , Oliveira Rúbia Maria Weffort 
Published: November 2022

Abstract
Phosphodiesterase 4 inhibitors (PDE4-I), which selectively increase cyclic adenosine monophosphate (cAMP) levels, have shown neuroprotective effects after several neurological injuries inducing blood-brain barrier (BBB) damage including local/focal cerebral ischemia. The present investigated whether roflumilast confers BBB neuroprotection in the hippocampus after transient global cerebral ischemia (TGCI) in rats. TGCI resulted in whole BBB disruption as measured by the increase of Evans blue (EB) and IgG extravasation, neurodegeneration, and downregulation of claudin-5 and endothelial nitric oxide synthase (eNOS) levels in the CA1 hippocampal subfield of ischemic rats. Roflumilast attenuated BBB disruption and restored the levels of eNOS in the CA1 hippocampal area. Moreover, roflumilast increased the levels of B2 cell lymphoma (BcL-2) and neuron-glial antigen-2 (NG2) in the CA1 subfield after global ischemia in rats. The protective effects of roflumilast against TGCI-induced BBB breakdown might involve preservation of BBB integrity, vascularization and angiogenesis, and myelin repair.
Associations between social engagement, internalizing symptoms, and delusional ideation in the general population
Authors: Hall Lauren M. , Moussa-Tooks Alexandra B. , Sheffield Julia M. 
Published: November 2022

Abstract
Background: Delusions are a hallmark feature of psychotic disorders and lead to significant clinical and functional impairment. Internalizing symptoms— such as symptoms of depression, anxiety, and trauma exposure—are commonly cited to be related to delusions and delusional ideation and are often associated with deficits in social functioning. While emerging studies are investigating the impact of low social engagement on psychotic-like experiences, little work has examined the relationship between social engagement, internalizing symptoms, and delusional ideation, specifically.
Methods: Using general population data from the Nathan Kline Institute-Rockland (NKI-Rockland) database (N=526), we examined the relationships between self-reported delusional ideation, internalizing symptoms, and social engagement and tested four indirect effect models to understand how these factors interrelate.
Results: Delusional ideation was significantly associated with both increased internalizing symptoms (r=0.41, p<0.001) and lower social engagement (r=-0.14, p=0.001). Within aspects of social engagement, perceived emotional support showed the strongest relationship with delusional ideation (r=-0.17, p<0.001). Lower social engagement was also significantly associated with increased internalizing symptoms (r=-0.29, p<0.001). Cross-sectional models suggest that internalizing symptoms have a significant indirect effect on the association between delusional ideation and social engagement.
Conclusions: These findings reveal that elevated delusional ideation in the general population is associated with lower social engagement. Elevated internalizing symptoms appear to play a critical role in reducing engagement, possibly exacerbating delusional thinking. Future work should examine the causal and temporal relationships between these factors.
Chinese Characters and Pinyin: A Model with Two Parallel Feature Extractors for Chinese Entity Recognition
Authors: Zhai Yuhui , Tian Shengwei , Yu Long , Wang Bo , Zhou Tiejun , Wang Yu , Gao Mandeng 
Published: November 2022

Abstract
The purpose of Named Entity Recognition (NER) is to identify and mark entities with specific meanings in a text. Compared with English NER, Chinese NER is blurry about the boundaries of entity classes because there is no clear separator between Chinese characters and Chinese entities are composed of several characters with different lengths. For Chinese NER, traditional methods only focus on Chinese characters, ignoring the important role of pronunciation. But for these models considering pronunciation, they put pronunciation and characters together for feature extraction. In this paper, we propose a Model with Two Parallel Feature Extractors. It uses a new Pinyin embedding layer that can handle characters except Pinyin and it uses Pinyin Encoder and Word Encoder to obtain the features of Pinyin and characters respectively and then features are fused through TextCNN. Compared with the previous model, this model is not as big as BERT, and it can get good results without additional data type training. We used four datasets: Resume, CCKS2019, CLUENER2020 and MSRA to test our model and it showed a good result, which proved the validity of our model.
A Multimodal Biometric Authentication System Using the Exponential Water Wave Optimization Algorithm
Authors: Vensila C , Wesley A. Boyed 
Published: November 2022

Abstract
The biometric system relies on a single biometric identifier which could not meet the desired performance required for personal identification. Hence, identification based on the multimodal biometric system is emerged in the research community to achieve the personal identification process more effective. Owing to the strong binding among user identity and biometric template, the user privacy is revealed and hence the security resulted in a major requirement in the biometric system. An authentication based multimodal biometric system is developed in this research by considering different modalities, such as fingerprint, finger vein, and face. Here, the bit string is generated from the biometric sample in such a way that the bit strings are fused by employing the proposed Exponential Water Wave Optimization (EWWO) algorithm based on the involvement of logic operations. However, the process of fusion is accomplished in such a way that it depends on the random selection of two logic operators by the developed optimization approach. Accordingly, the developed EWWO is derived by the combination of Exponentially Weighted Moving Average (EWMA) and Water Wave Optimization (WWO) respectively. The authentication mechanism is achieved by employing the biometric template with the encoder and decoder operation. Moreover, the proposed method achieved the performance for Equal Error rate (EER), False Acceptance Rate (FAR), and False Rejection Rate (FRR) with the value of 0.0717, 0.0745, and 0.0689, respectively.
Prevalence of Anemia and Admission Outcome Among Anemic Compared to Non-anemic Patients Admitted in Internal Medicine at University Teaching Hospital of Kigali: a Non Randomized Comparative Study.
Authors: Havugimana Phocas , Babane Felix , Ntabanganyimana Etienne , Ntihinyurwa Polyphile , Mushimiyimana Diane , Masaisa Florence 
Published: November 2022

Abstract
Background: Admitted patients with anemia are at increased morbidity and mortality risk as well as length of hospital stay. To the best of our knowledge, there is no study done in Rwanda assessing the prevalence of anemia and admission outcome among admitted patients and few studies are done in sub-Sahara Africa. We aimed to determine the prevalence of anemia in admitted patients but also their length of hospital stay and mortality risk in anemic patients compared to non-anemic patients.
Method: We recruited 143patients at University Teaching Hospital of Kigali between March and April 2021 and follow them up until discharge. Sociodemographic and clinical information was collected for all eligible patients. The associations were tested using chi-square tests. The outcome variable (anemia) was cross tabulated with all factors associated with anemia.
Results: The Prevalence of anemia was 52.4% among 143 enrolled patients and the majority had Normocytic anemia with 41.9%. Hypertension and Diabetes were the most common comorbidities found in 50 (35%) and 37 (25.9%) of respondents respectively. CKD (OR 12.108, p0.001), Cancer (OR 10.488; p 0.027) and HIV/AIDS had higher odds of developing anemia. Mortality rate was 13.3 % in all participants but the mean Hemoglobin of patients who died was lower compared to the mean hemoglobin of patients who were discharged alive with 11.4±4.1g/dL and 12±3.3 g/dL respectively (P-value 0.551). Patients with severe anemia were 4 times more likely to die while mild and moderate anemia did not significantly impact the likelihood of death compared to patients with normal Hemoglobin. Hemoglobin level correlates with the length of hospital stay as the lower the hemoglobin level, the longer the hospital stay was (P-value 0.010).
Conclusion: Anemia is prevalent among in-patients at CHUK patients with CKD, cancers, and HIV/AIDS as leading predisposing factors. Patients with anemia are at increased risk of mortality and longer length of hospital stay compared to those with normal hemoglobin level.
An SDN Architectural Framework for VANET Security and Data Storage
Authors: Priyadarsini Madhukrishna , Bera Padmalochan , Rout Jyotiranjan 
Published: November 2022

Abstract
Vehicular Ad hoc NETworks (VANETs) are an active area of research because of their potential to improve road safety and to enhance traffic efficiency. High dynamic connections, sensitive information sharing, and time-sensitivity nature of VANET make it an eye-catching field for attackers. Software-defined networking (SDN) can be used to implement any network, due to the separation of the control program and data plane. In this paper, we have proposed an SDN architectural framework to enhance the storage capacity and to provide security to prevent specific VANET attacks. The storage capacity is enhanced using B+ tree and the security to the storage is provided using X.509 public key certification. On the other hand, we have used signaling game-theoretic solutions in the architectural framework to prevent the attacks. The framework provides end-to-end security to the communication between devices of VANET. Experimentation results show efficient data retrieval with less computational complexity and 98% attack detection and prevention with high throughput and less delay.
Post-HSCT maintenance treatment using entrectinib for an AML patient accompanied ETV6-NTRK3: a case report
Authors: Zhao Xiaoli , Hao Mengze , Zhang Xiaoyu , Wei Jialin , Feng Sizhou , He Yi , Jiang Erlie , Han Mingzhe 
Published: November 2022

Abstract
The neurotrophic receptor tyrosine kinases (NTRKs) gene fusions occur in many different tumors, and tropomyosin receptor kinase (TRK) inhibitors exhibit attractive antitumor activity. This case report presents that a patient with refractory AML accompanied ETV6-NTRK3 was failed in traditional chemotherapy, then received continue remission after hematopoietic stem cell transplantation (HSCT) and maintenance therapy with entrectinib. This is the first time that TRK inhibitor has been used in patient with AML after HSCT.