bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histopathological growth patterns determines the outcomes of colorectal cancer liver metastasis that have undergone liver resection
Authors: Krzywon Lucyna , Lazaris Anthoula , Petrillo Stephanie , Zlotnik Oran , Gao Zu-Hua , Metrakos Peter 
Published: October 2022

Abstract
Introduction:
Colorectal cancer liver metastasis (CRCLM) remains a lethal diagnosis with an overall 5-year survival rate of 5–10%. Two distinct histopathological growth patterns (HGPs) of CRCLM are known to have significantly differing rates of patients survival, and response to treatment. We set out to review the results of 275 patients who underwent liver resection for CRCLM at the McGill University Health Center (MUHC) and analyze their clinical outcome, mutational burden and pattern of cancer progression in light of their HGP’s, and to consider their potential effect on surgical decision making.
Methods
We performed a retrospective multivariate analysis on clinical data from patients with CRCLM (n = 275) who underwent liver resection at the McGill University Health Center (MUHC). All tumors were scored using international consensus guidelines by pathologists trained in HGP scoring.
Results
109 patients (42.2%) were classified as desmoplastic and angiogenic whereas 149 patients (57.7%) were non-desmoplastic and vessel co-opting. The 5 year survival rates for angiogenic patients compared to vessel co-opting patients was 47.1% and 13% respectively (p < 0.0001). Multivariate analysis showed patients with vessel co-opting CRCLM had a higher incidence of extrahepatic metastatic disease (p = 0.0215) compared to angiogenic CRCLM. Additionally, KRAS mutation status was a marker of increased likelihood of disease recurrence (p = 0.0434) as was increased number of liver tumors (p = 0.0071) and multiple sites of extrahepatic metastatic disease (p < 0.0001).
Conclusions
Multivariate analysis identified key clinical prognostic and molecular features correlating to the two HGPs. Determining liver tumor HGPs is essential for patient prognostication and treatment optimization.
A Novel Multi-attention Fusion Convolution Neural Network for Blind Image Quality Assessment
Authors: Wang Changzhong , Zhang Shuyu , Lv Xiang , Ding Weiping , Fan Xiaodong 
Published: October 2022

Abstract
As an underlying computer vision task, blind image quality assessment plays an important role in image evaluation. According to the Human Vision System (HVS), when observing an image, people's visual attention will be more sensitive to the region of their concern, which shows that attention mechanism is very helpful for image quality assessment. Therefore, in blind image quality assessment, many attention mechanisms were used to extract the features of concerned regions. However, most of the existing methods only cascaded multiple attention mechanisms to extract features, which greatly weakened the effect of the fusion of multiple attention mechanisms. Based on this, we propose a multi-attention fusion convolution neural network (MAFCN), which can extract the features of interest region from different aspects. In this network, a multi-attention fusion unit (MAFU) is proposed which can adaptively fuse three types of attention mechanisms and give full play to the ability of each attention mechanism to extract features. In addition, skip connections are added to the network to supplement local information and missing details. Experimental results show that MAFCN has better performance and strong generalization ability without wasting resources.
Effect of peppermint aroma on physiological parameters of mechanically ventilated patients: Randomized placebo controlled trial
Authors: Baraka Azza , Hassan Eman 
Published: October 2022

Abstract
Background
Mechanical ventilation increases stress and anxiety of critically ill patients and subsequently physiological parameters of these patients. Peppermint inhalation reduces stress and improves physiological parameters in many studies, but none of these studies used peppermint inhalation yet for mechanically ventilated patients.
Methods
Randomized placebo controlled trial. Data for this study were collected from 1 June to 12 September 2022. Patients who were conscious on mechanical ventilation via endotracheal tube were randomly assigned to two groups. The intervention group received peppermint inhalation intervention, and the placebo group received almond inhalation intervention. Patients in both groups were assessed for their smell ability by Sniffin Sticks-test before starting the interventions. CONSORT checklist was used to report the study. This study was conducted in six intensive care units.
Results
A total of 52 patients in the intervention group and 54 patients in the placebo group completed the study. Pain score was significantly decreased in the intervention group after starting the intervention in comparison to the placebo group. There was a strong positive correlation between Sniffin Sticks-test score and the decrease in pain score after inhalation of peppermint.
Conclusion/ Implications for practice:
Inhalation of mechanically ventilated patients to peppermint decreases pain score. The effectiveness of peppermint inhalation is correlated to the smell ability of the patients.
Trial registration:
The identification number of the registered trial to the Clinical Trials Online Registry is: NCTXXXXXXX.
Spherical Fuzzy Soft Rough Sets and Their Applications in Decision Making Problems
Authors: Mahmood Tahir , Ahmmad Jabbar , Rehman Ubaid ur 
Published: October 2022

Abstract
Soft set theory, established by Molodtsov is the universal mathematical structure to tackle the vagueness in data. Since soft set can consider the parameterization structure and spherical fuzzy rough set (SFRS) is a dominant structure to categorize the objects, so due to this reason, here in this manuscript, we have combined, crisp soft relation and fuzzy soft relation respectively with SFRS tointroduce the idea of soft rough spherical fuzzy set and spherical fuzzy soft rough set which can be seen as two new universal soft rough set concepts. Moreover, the classical representations of approximation operators and approximation operators have been established and their properties are discussed in detail. Furthermore, an algorithm is given based on established work and illustrative example is proposed to show how the given idea works in decision making (DM) problems. Finally supremacy of the introduced work is shown and comparative analysis with existence tools by numerical example is established.
Research and modeling of oil refining technological processes operating in the condition of stochastic uncertainty
Authors: Safarova Aygun , Damirova Javida 
Published: October 2022

As it is known, one of the initial and important stages in the creation of optimal control systems of oil refining technological units is the development of a mathematical model that can adequately record the processes at any time.
The operative and accurate measurement of all input and output variables is one of the important conditions in the development of a mathematical model of technological processes.
Studies have shown that the lack of information about the state of complex oil refining processes in many cases reduces their efficiency and effectiveness. On the other hand, the wide range of both quality and quantity of raw materials for processing makes their efficiency even more unsatisfactory. Under these conditions, it is difficult to develop mathematical models that can adequately describes the static modes of technological processes; the development of mathematical models is relevant both in scientific and practical terms.
A priori information required on input and output variables during normal operation of the technological complex in order to implement mathematical models identification for the vacuum block of the oil refining process unit is provided in the article. On the basis of this static information, mathematical dependencies were constructed between the variables characterizing the static mode of technological processes and the adequacy of the obtained mathematical models was confirmed through the statistical apparatus
In order to solve the problems, the research was determined to be able adequately describe the current technological conditions, which can quickly adapt to current technological situations and ensure the production of oil fractions with relatively stable quality, regardless of the disturbing effects of the system
Enterprise risk arising from legacy production systems: a probabilistic perspective
Authors: Bludova Tetiana , Usherenko Svitlana , Moskovchuk Alla , Kaminska Iryna , Kyslytsyna Olga 
Published: October 2022

The model of estimation of effective minimization of strategic risks arising at modernization of the software of legacy production systems is presented. It is shown that incompatible hypotheses of strategic risks of the enterprise in the digital economy form a complete group of pairwise incompatible independent events, and their probabilities are found by mathematical methods of processing an inversely symmetric matrix, made by experts in pairwise comparison on a 5-point scale of relative importance errors of calculations of the constructed matrix (no more than 15 %). For these matrices, solutions of characteristic equations are found to determine the maximum values of the eigenvalues of matrices, which appear in the assessment of the adequacy of composite expert matrices together with the corresponding orders of matrices.
To substantiate the statistical measurement under the condition of quantitative or qualitative assessment of the risk of occurrence of events, the a priori value of the probabilities of occurrence of risk in the occurrence of events is taken. The full probability formula is the formula for the probability of occurrence of an event of effective minimization of strategic risks. It is shown that to determine the a priori values of conditional probabilities of hypotheses of effective minimization of strategic risks of the enterprise it is necessary to make statistically significant sections of these hypotheses at selected enterprises for several periods, which may be subject to statistical distribution laws. Thus, the presented model for quantitative measurement, comprehensive analysis of the level of software modernization of legacy production systems of the enterprise is the initial theoretical basis for improving the system of strategic management of the enterprise in terms of digitalization.
Simulation study of horizontal axis wind turbine using PVC pipe propeller with elbow tip
Authors: Wahyudi Bagus , Faizin Akhmad , Setiawan Andri , Susilo Sugeng Hadi , Wicaksono Hangga 
Published: October 2022

The potential of wind as an energy resource is still not widely used by the community through simple technology to produce electrical power. One simple technology is to use PVC pipe as the basic material for making wind turbine propellers. The purpose of this study was to determine the effect of variations in angle of attack and wind speed on the performance of a PVC pipe propeller wind turbine with an Elbow Tip. Material of blade propeller made by PVC pipe are slice half and twist from hub until tip with 90 degree of rotation. Dimension of width blade wider on the hub (3/4 of circular) and smaller on the tip (1/7 of circular). Face of blade on the hub side facing wind direction (axial) and face of blade on the tip side facing tangential direction or opposite with rotation. On the tip side installed the slice elbow with fit tip blade width. The propeller using PVC pipe with elbow tip is the important part of new design which has been test with CFD simulation and wind tunnel research with best result performance. This research uses CFD simulation and experimental methods with a comprehensive study of the aerodynamic behaviour characteristics in and around the turbine rotor. The results of the CFD simulation was found that the phenomenon positioning of momentum force were place on the outer radius due to addition elbow tip cause increasing the torque. By using elbow tip on blade propeller PVC Pipe Horizontal Axis Wind Turbine with 15° and 30° angle of attack could increasing torque about 200 % than without the elbow tip. Beside, using 45° angle of attack although additional with elbow tip could not increasing the torque when the wind speed on 7 m/s. The result of this research is important to know by public who interest build small grid wind turbine with low cost and easy manufacturing.
Life satisfaction in the caregivers of schizophrenia and factors associated with it: a cross sectional study from South India
Authors: Rajendran Arunima , Gurushanthappa Yashwant , Akkineni Shilpa 
Published: October 2022

Schizophrenia is a mental disorder characterized by distortions of thinking and perception, in the process of care giving the caregivers are faced with many challenges. These challenges have a significant impact on the life satisfaction of caregivers. The study investigates various factors associate with life satisfaction in caregivers of schizophrenia
The aim: 1. To evaluate the socio-demographic correlates associated with life satisfaction in the care givers of schizophrenia.

To evaluate the association between life satisfaction with resilience, anxiety, stress, depression perceived social support, self-esteem, self-efficacy, and perceived stigma in the care takers of schizophrenia patients.

Material and methods. In cross sectional study, 513 care takers of schizophrenia were evaluated using semi-structured socio demographic perfoma, DASS-21, Connor-Davidson Resilience 25 item scale, Self Esteem Scale (Rosenberg), The Satisfaction with Life Questionnaire and family stigma stress scale.
Result. The study showed that background of the caregiver, socioeconomic status, family type, education and marital status are significantly positive correlated with life satisfaction. The study also showed significant positive correlation between resilience, perceived social support, self-esteem and self-efficacy with life satisfaction. There is also significant negative correlation between perceived stigma, anxiety stress and depression with life satisfaction.
Conclusion. The study showed that life satisfaction in the care givers of schizophrenia depends on different biopsychosocial variables. There is strong positive correlation between self-esteem, other person support and resilience with life satisfaction, whereas there is moderate positive correlation between self-efficacy, family support and friend support with life satisfaction. There is significant negative correlation between stress, anxiety, depression, and stigma with life satisfaction. We recommended psycho educational interventional programmes in the community level which help to increase resilience self-esteem and self-efficacy. Such programmes also decrease the stigma which in turn increases the social support to the caregivers
Research of medical and biological indicators of eggplant powder
Authors: Dzyundzya Oksana , Antonenko Artem , Brovenko Tеtіana , Tolok Galina , Kryvoruchko Myroslav , Bozhko Tetiiana , Antiushko Dmytro , Vezhlivtseva Svitlana , Voievoda Nadiia , Skliarenko Kateryna 
Published: October 2022

The aim of the work is to study the medical and biological properties of eggplant powders.
Eggplant food powder is a raw material, an important characteristic of which is its chemical composition, in particular dietary fibers (pectin and fiber). Eggplant powders obtained by infrared drying of raw materials with subsequent grinding to 0.41/0.43 mm were used for the research.
The low degree of esterification gives the powders increased sorption and detoxification properties for a number of heavy metal cations. It has been established that the ability of eggplant powder to bind heavy metals reaches 40‒50 %, a detoxification effect occurs, exogenous and endogenous poisons are adsorbed, and the putrefactive intestinal microflora decreases. It was established that the binding effect is influenced by the amount of protopectin and the pH of the medium, which is determined by the content of organic acids in eggplant powders. The obtained results confirm the complex-forming ability of the powders.
Adding eggplant powder to the diet of rats reduces cholesterol by an average of 12 %. 10 % content of eggplant powder in the diet reduces the content of lipoproteins in the blood (up to 3.2 %), cholesterol (up to 1.9 %).
Medical and biological studies establish the positive effect of raw materials on the animal body and determine the expediency of using a functional ingredient. In general, eggplant powder can be used as an effective supplement to reduce cholesterol and lipoproteins, which does not affect the main physiological systems of the body.
The prospect of further research is an in-depth study of the chemical composition of raw materials, the development of recipes for dishes using eggplant powders.
Clinical and pathomorphological changes in mycotoxicosis of cows
Authors: Chekan Oleksandr , Shkromada Oksana , Sevastianov Vitalii 
Published: October 2022

The defeat of feed by microscopic fungi is a fairly common phenomenon at this stage of the management of the agricultural sector. This is due to weather conditions (high rainfall) and errors in harvesting and storage of grain. Feeding affected feed leads to irreversible processes in the body of cows, reducing their productivity. The aim of the study was to establish marker indicators for the rapid diagnosis of mycotoxicoses in cows. So, when exposed simultaneously to T-2 toxin and toxins of the fungus Aspergillus fumigatus, destructive changes in the skin and mucous membranes were diagnosed, and pathology of the limbs was diagnosed, which was characterized by lameness. The laboratory revealed an increase in the level of leukocytes up to 37.1 g/l and a decrease in the content of hemoglobin in the blood of sick animals. Also, a characteristic feature was the latch of the contents of the rumen at pH 8.0, which in turn leads to a decrease in the number of ciliates. Also a sign of poisoning are changes in the fecal matter: liquid, musty odors and with an increased pH of up to 7.5. At the autopsy of the dead animals, a characteristic sign was: necrosis of the mucous membranes of the oral cavity, esophagus, gastrointestinal tract, protein degeneration in the liver and kidneys, and serous pulmonary edema. Infertility is 67.35 %, which leads to multiple unsuccessful insemination, which is due to destructive changes in the organs of the reproductive system. So, in sick animals, ovarian hypotrophy was diagnosed at the level of 54.09 %, ovarian cysts v in 8.18 %, yellow persistent bodies in the postpartum period – 7.54 %. The prospect of further research will be the development of preventive methods for treating cows and increasing their reproductive function of mycotoxicoses.
Spatial and temporal variation characteristics and attribution analysis of land water storage changes in China
Authors: Zhu Jiangle , Zhang Chunsen , Zhang Jiazheng , Ding Hao 
Published: October 2022

AbstractThe quantitative study of terrestrial water storage change (TWSC) and its spatial and temporal dynamics has been an important topic in water resources research and management. In this study, we invert the characteristics of TWSC in China based on the GRACE time-varying gravity field model and explore its attribution analysis, using Theil- Sen Median trend, Mann-Kendall test and geographic detector, as well as the geographically and temporally weighted regression model (GTWR), combined with meteorological and drought indicators and other data to analyze the relationship between their drivers. The results are as follows: (1) The influencing factors of TWSC's high effect are minimum temperature, precipitation and maximum temperature, and the explanatory power of TWSC through factor interaction is much higher than that of a single factor; (2) The GTWR model is better than GWR models in determining the relationship between influencing TWSC and drivers, and there are temporal and local differences in the influence of each driver on TWSC; (3) In summer and autumn, the rise of water storage in central China is higher than that in east and west China. In spring and winter, the overall water storage in China shows a deficit, and some regions in Guizhou, Guangdong and Guangxi have a small surplus compared with other regions.
Stream flow prediction using TIGGE ensemble precipitation forecast data for Sabarmati river basin
Authors: Patel Anant , Yadav S. M. 
Published: October 2022

Abstract
Flooding is the most prevalent natural disaster globally. Increasing flood frequency affects developing nations as these countries lack strong forecasting systems. The most flood-prone urban regions are near the coast or riverbanks. Using The International Grand Global Ensemble (TIGGE) data, a coupled atmospheric-hydrologic ensemble flood forecasting model for the Sabarmati river was developed. Incorporating numerical weather prediction (NWP) information into flood forecasting systems can increase lead times from hours to days. When predicting the weather, we employed numerous NWP models from various prediction centers. European Center for Medium Range Weather Forecasts (ECMWF), United Kingdom Meteorological Office (UKMO) and National Centers for Environmental Prediction (NCEP) data with a 5-day advance time are coupled with the HEC-HMS model to provide ensemble stream flow predictions. The ensemble flood forecasting model uses the 2015 flood season as a test scenario. In this research, we discovered that TIGGE ensemble prediction data can be useful for prediction of stream flow and results showed effective flood forecasting for Sabarmati river. HEC-HMS, a semi-distributed hydrologic model, uses ECMWF, NCEP, and UKMO precipitation ensembles. ECMWF shows that 90% of the correlation with observed data and peak time and peak discharge is also match with the observed discharge with a peak on 29 July 2015 with 9,300 cumecs. Danger probability may be accurately predicted based on peak time and flood warning probability distributions.
Evidence for the identity of rat liver microsomal membrane-bound serine proteinase with hepsin
Authors: Takahashi Kenji , Matsuzaki Hidemi , Jeohn Gwang-Ho , Iwamatsu Akihiro , Tamanoue Yoshiaki , Kim Yong-Tae , Takahashi Takayuki 
Published: October 2022

Abstract:
The serine proteinase previously isolated and partially characterized from the microsomal membrane fraction of rat liver was shown to be composed of two peptide chains of molecular masses of approximately 31 kDa and 19 kDa cross-linked by disulfide bond(s). Partial sequence analysis of peptides obtained by enzymatic hydrolysis indicated that the enzyme shares the same amino acid sequence with rat hepsin. These results provide evidence for the identity of these two enzymes.
Purification, crystallization and preliminary x-ray analysis of a phycourobilin-containing phycoerythrin
Authors: Diederichs Kay , Rittert Stephan , Hiller Roger G. , Wrench Pamela M. , Wacker Thomas , Welte Wolfram 
Published: October 2022

Abstract:
Rhodophycean phycoerythrin (R-PE) was isolated from the red alga Griffithsia monilis and purified on Q­ Sepharose. Untwinned crystals diffracting to 2.lA on a rotating anode X-ray source were obtained by the hanging-drop vapour diffusion method, and their space group determined as R3. SDS gel-electrophoresis of dissolved crystals showed the a and p subunits of the protein (apparent molecular weight, about 19 kDa) and
two different forms of they-subunit (apparent molecular weight, 28 and 30 kDa) being present in the crystals.
Crystallization of a hydrolase from rhodococcus sp. strain rhal, the bphd enzyme, in the pcb degradation pathway
Authors: Mitsui Yukio , Nandhagopal N. , Senda Toshiya , Hatta Takahashi , Yamada Akihiro , Masai Eiji , Fukuda Masao 
Published: October 2022

Abstract:
Crystals have been obtained for a 2-hydroxyl-6-oxo-6-phenylhexa-2,4-dienoic (HPDA) acid hydrolase (conventionally called as BphD) cloned from Rhodococcus sp. strain RHAl. The crystals were grown using both PEG 4000 and isopropanol as the precipitating agents. The crystals belonged to a tetragonal space group (/422) and diffracted to 2.5A.