bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Water Synthesis of 3-Aryl-5,7-dimethyl-1,2,4-triazolo[4,3-a]pyrimidines using Iodobenzene Diacetate
Authors: Soni Rinku , Aneja Deepak Kumar , Sihag Monika , Rani Neha , Kinger Mayank 
Published: October 2022

Abstract:A simple and green methodology has been developed for the synthesis of 3-aryl-5,7- dimethyl-1,2,4-triazolo[4,3-a]pyrimidines in water. Oxidative cyclization of 4,6-dimethyl-2- pyrimidinylhydrazones of different aldehydes was achieved in good to excellent yield using iodobenzene diacetate at room temperature. High efficiency, easy work-up, short reaction time, non-toxicity of solvent and ambient temperature are the advantages of this methodology.
Adsorption of Diethylstilbestrol Drug into BNNT: DFT/TD-DFT and Spectroscopic
(Excited States, UV/Vis and NMR) Studies
Authors: Hosseinzadeh Maryamossadat , Masoudi Shiva , Masnabadi Nasrin , Azarakhshi Fatemeh 
Published: October 2022

Abstract:
Cancer has become a significant universal health problem. Anticancer drugs control the chemicals that sacrifice cancer cells by inhibiting their growth in their cell cycle. Interestingly, as much as boron nitride nanosheets and boron nitride nanotubes are degradable and non-toxic, they can act as suitable drug carriers for antitumor drugs and deliver them into target cells. In the present study, the encapsulation of diethylstilbestrol as an anticancer drug into the boron nitride (8,8) nanotube was investigated for the first time using the density functional theory: M06-2X and the natural bond orbital methods in the gas phase. Using natural bond orbital analysis, the charge transfer between diethylstilbestrol drug and boron nitride nanotubes (8,8)/ diethylstilbestrol complex was explored.
Based on the results obtained from the calculation of encapsulation energy, it was found that the adsorption process was favorable. The interaction effects of diethylstilbestrol drug and boron nitride (8,8) nanotube on the natural bond orbital charge, the chemical shift parameters, and electronic properties were also evaluated. This study revealed that boron nitride (8,8) nanotubes can be a suitable carrier for diethylstilbestrol drug delivery. The ultra violet-visible spectra of diethylstilbestrol drug and the boron nitride (8,8) nanotubes/diethylstilbestrol complex were computed using time-dependent density functional theory (: M06-2X calculations.
Toxicity, Safety, and Pharmacotherapeutic Properties of Ursolic Acid:
Current Status, Challenges, and Future Perspectives against Lung Cancer
Authors: Subramanian Chandrakumar , Solairaja Solaipriya , Dunna Nageswara Rao , Venkatabalasubramanian Sivaramakrishnan 
Published: October 2022

Abstract:
Lung cancer is often associated with the second leading cause of mortality in males globally. Despite clinical advancements, their incidence in humans has not decreased. Hence identifying and developing alternative or complementary therapeutic agents with evidence targeting lung cancer is of considerable interest. Ursolic Acid (UA): a dietary flavonoid present in herbs, vegetables, and fruits can effectively alleviate the hallmarks of lung cancer. As a molecular therapeutic agent, UA disrupts prolonged inflammation, augments antioxidant enzyme defense, attenuates tumor growth signal, tissue invasion/metastasis, limits unrestrained proliferation, fosters apoptosis, and regulates immune response in lung cancer. This review will most notably focus on the current source of UA availability, phytochemistry, bioavailability, safety, toxicity, and salient pharmacotherapeutic properties in addition to the preclinical and clinical information currently available to recommend UA as a potential therapeutic agent for lung cancer targeting and prevention.
Progress in Analytical Techniques for Remogliflozin Etabonate, Vildagliptin And Metformin Hydrochloride: A Recently, Approved FDC
Authors: Kotadiya Rajendra , Joshi Prachi 
Published: October 2022

Background:Fixed-dose combinations (FDCs) are renowned formulations that contain two or more drugs pooled in a single dosage form. Their recognition is justified due to several advantages, such as impending therapeutic efficacy, reducing the episodes of adverse drug effects, having pharmacokinetic advantages, reducing pill burden, reducing the dose of individual drugs, and decreasing drug resistance development.Objective:Recently, an FDC tablet of remogliflozin etabonate (100 mg), vildagliptin (50 mg), and metformin HCl (500/1000 mg) has been approved for the treatment of type 2 diabetes mellitus. No analytical method has been reported thus far for this newly approved combination.Methods:Thus, this review collected and simplified information on reported analytical techniques and physicochemical and biological properties for the above-cited FDCs. The authors have explored various authenticated scientific journals, and simplified information was presented to meet the objectives.Results:The reported methods are spectroscopy (40%, 20% & 33%), HPTLC (10%, 14% & 20%), HPLC (50%, 49% & 41%), hyphenated techniques (Nil, 14% & 5%) and electrophoresis methods (Nil, 2% & 1%) for remogliflozin etabonate, vildagliptin and metformin HCl, respectively.Conclusion:Such extensive data would be useful to analysts in developing an analytical method for the analysis of the recently approved FDCs
TMMGdb - Tumor Metastasis Mechanism-associated Gene Database
Authors: Ng Ka-Lok , Liu Hsueh-Chuan , Mekala Venugopala Reddy , Huang Chien-Hung 
Published: October 2022

Background:
At present, all or the majority of published databases report metastasis
genes based on the concept of using cancer types or hallmarks of cancer/metastasis. Since tumor metastasis
is a dynamic process involving many cellular and molecular processes, those databases cannot
provide information on the sequential relations and cellular and molecular mechanisms among
different metastasis stages.

Objective:
We incorporate the concept of tumor metastasis mechanism to construct a tumor metastasis
mechanism-associated gene (TMMG) database based on using the metastasis mechanism concept.

Methods:
We utilized the text mining tool, BioBERT to mine the titles and abstracts of the papers
and identify TMMGs.

Results:
This tumor metastasis mechanism-associated gene database (TMMGdb) contains a wealth
of annotations.To check the reliability of TMMGdb, we compared the proportions of housekeeping
genes (HKGs) in TMMGdb, HCMDB, and CMgene, the results showed that around 20% of the
TMMGs are HKGs, and the proportions are highly consistent among the three databases. Compared
with the HCMDB and CMgene databases, TMMGdb is able to find a more recent (on or after 2017)
collection of publications and TMMGs. We provided six case studies to illustrate the uniqueness of
the TMMGdb database.

Conclusion:
TMMGdb is a comprehensive resource for the biomedical community to understand the dynamic
process, molecular features, and cellular processes involved in tumor metastasis. TMMGdb provides
four interfaces; ‘Browse’, ‘Search’, ‘DEG Search’ and ‘Download’, for users to investigate the causal
effects among different metastasis stages; the database is freely accessible at http://hmg.asia.edu.tw/
TMMGdb.
Ethnotherapeutic Uses of Aquatic Animals in the North Eastern Region of
India: A Preliminary Observation
Authors: Dutta Uma , Daimari Enush 
Published: October 2022

Abstract:
Since ancient times humans have been associating themselves with animals to derive various
benefits which include the therapeutic values of animals. Zootherapy is in practice among the
indigenous people of various parts of the world. The indigenous people living in the North Eastern
(NE) region of India also know the medicinal values of animals and they have been using many animals
in the treatment of various health ailments. This region is bestowed with many nature’s gifts,
among which the vast water bodies are considered the best. The diverse terrain of the region has
made varieties of aquatic animals exist. Hence, it has become favourable for the indigenous people
to use the easily available resources - aquatic animals for the treatment of health ailments. This precious
indigenous knowledge is restricted locally and is handed down from one generation to the
other through verbal communication. Consequently, this knowledge has started perishing. Making
proper documentation of the traditional uses of aquatic animals of this region in the treatment of
health ailments is intended in the present study. Attempts have also been made to reveal the presence
of bioactive components in the aquatic animals of the region. The present study will be helpful
while analyzing the therapeutic potentials of aquatic animals and then preparing drugs for clinical
purposes.
Evaluation of Breastfeeding App Features: Content Analysis Study
Authors: Dinour Lauren M , Pole Antoinette 
Published: October 2022

Background
While a variety of health apps abound, less than half of adults in the United States report using a health app, despite the ubiquity of smartphones among users aged 18 to 49 years. Several studies have examined the use of breastfeeding apps; however, less is known about the types of features found on these apps and what factors might influence app ratings.

Objective
This paper seeks to characterize breastfeeding apps, assess whether apps with higher user ratings differ from apps with lower user ratings in their tracking and nontracking features, and analyze whether the type and number of features predict user star ratings and whether an app is higher- or lower-rated.

Methods
Using a cross-sectional design, a convenience sample of breastfeeding apps was culled from the Apple App Store (iOS) and Google Play Store (Android). Content analysis of the apps (N=82) was conducted using a schema of 87 items, which was then compiled into 9 topical indices for breastfeeding, bottle feeding, solid foods, infant health, infant care, technical characteristics, informatics, informational characteristics, and interactivity. Analysis consisted of descriptive statistics, the Mann-Whitney U test, and Spearman rank correlations. Linear regression and binary logistic regression analyses were conducted to determine which features predicted user star ratings.

Results
On average, users rated breastfeeding apps 4.4 of 5 stars. Two-thirds of apps (n=54) were higher rated (≥4.5 stars), and one-third (n=28) were lower rated (<4.5 stars). Higher-rated apps offered more tracking features for breastfeeding, bottle feeding, solid foods, infant health, and infant care than lower-rated apps. The breastfeeding, solid-food, and technical indices explained 17% of user star ratings. For each additional breastfeeding and solid-food feature, we can expect to see a 27% and 35% increase, respectively, in user star ratings. Additionally, as the number of solid-food features increased, the odds that the app is higher rated increased 1.58 times.

Conclusions
Our findings suggest user ratings are driven in part by tracking features, specifically those related to breastfeeding and solid foods. The proliferation of mobile health apps offers opportunities for parents and caregivers to track behaviors associated with infant feeding and other health metrics in a dynamic, detailed, and comprehensive manner. Hence, breastfeeding apps have the potential to promote and support breastfeeding among users.
Evaluating the Impact on Clinical Task Efficiency of a Natural Language Processing Algorithm for Searching Medical Documents: Prospective Crossover Study
Authors: Park Eunsoo H , Watson Hannah I , Mehendale Felicity V , O'Neil Alison Q ,   Clinical Evaluators
Published: October 2022

Background
Information retrieval (IR) from the free text within electronic health records (EHRs) is time consuming and complex. We hypothesize that natural language processing (NLP)–enhanced search functionality for EHRs can make clinical workflows more efficient and reduce cognitive load for clinicians.

Objective
This study aimed to evaluate the efficacy of 3 levels of search functionality (no search, string search, and NLP-enhanced search) in supporting IR for clinical users from the free text of EHR documents in a simulated clinical environment.

Methods
A clinical environment was simulated by uploading 3 sets of patient notes into an EHR research software application and presenting these alongside 3 corresponding IR tasks. Tasks contained a mixture of multiple-choice and free-text questions. A prospective crossover study design was used, for which 3 groups of evaluators were recruited, which comprised doctors (n=19) and medical students (n=16). Evaluators performed the 3 tasks using each of the search functionalities in an order in accordance with their randomly assigned group. The speed and accuracy of task completion were measured and analyzed, and user perceptions of NLP-enhanced search were reviewed in a feedback survey.

Results
NLP-enhanced search facilitated more accurate task completion than both string search (5.14%; P=.02) and no search (5.13%; P=.08). NLP-enhanced search and string search facilitated similar task speeds, both showing an increase in speed compared to the no search function, by 11.5% (P=.008) and 16.0% (P=.007) respectively. Overall, 93% of evaluators agreed that NLP-enhanced search would make clinical workflows more efficient than string search, with qualitative feedback reporting that NLP-enhanced search reduced cognitive load.

Conclusions
To the best of our knowledge, this study is the largest evaluation to date of different search functionalities for supporting target clinical users in realistic clinical workflows, with a 3-way prospective crossover study design. NLP-enhanced search improved both accuracy and speed of clinical EHR IR tasks compared to browsing clinical notes without search. NLP-enhanced search improved accuracy and reduced the number of searches required for clinical EHR IR tasks compared to direct search term matching.
Social Media Recruitment Strategies to Recruit Pregnant Women Into a Longitudinal Observational Cohort Study: Usability Study
Authors: Pekarsky Chloe , Skiffington Janice , Leijser Lara M , Slater Donna , Metcalfe Amy 
Published: October 2022

Background
Use of social media for study recruitment is becoming increasingly common. Previous studies have typically focused on using Facebook; however, there are limited data to support the use of other social media platforms for participant recruitment, notably in the context of a pregnancy study.

Objective
Our study aimed to evaluate the effectiveness of Facebook, Twitter, and Instagram in recruiting a representative sample of pregnant women in a longitudinal pregnancy cohort study in Calgary, Alberta, between September 27, 2021, and April 24, 2022.

Methods
Paid advertisements were targeted at 18- to 50-year-old women in Calgary, with interests in pregnancy. Data regarding reach, link clicks, and costs were collected through Facebook Ads Manager (Meta Platforms, Inc) and Twitter Analytics (Twitter, Inc). The feasibility of each platform for recruitment was assessed based on the recruitment rate and cost-effectiveness. The demographic characteristics of the participants recruited through each source were compared using the chi-square test.

Results
Paid advertisements reached 159,778 social media users, resulting in 2390 link clicks and 324 participants being recruited. Facebook reached and recruited the highest number of participants (153/324, 47.2%), whereas Instagram saw the highest number of link clicks relative to the number of users who saw the advertisement (418/19,764, 2.11%). Facebook and Instagram advertisements were cost-effective, with an average cost-per-click of CAD $0.65 (US $0.84; SD $0.27, US $0.35) and cost-per-completer of CAD $7.89 (US $10.25; SD CAD $4.08, US $5.30). Twitter advertisements were less successful in terms of recruitment and costs. Demographic characteristics of participants did not differ based on recruitment source, except for education and income, where more highly educated and higher-income participants were recruited through Instagram or Twitter. Many issues related to fraudulent responses were encountered throughout the recruitment period.

Conclusions
Paid social media advertisements (especially Facebook and Instagram) are feasible and cost-effective methods for recruiting a large sample of pregnant women for survey-based research. However, future research should be aware of the potential for fraudulent responses when using social media for recruitment and consider strategies to mitigate this problem.
THE IDEAS ABOUT LOGIC AS AN ACADEMIC DISCIPLINE IN THE CONTEXT OF THE REFORMS OF RUSSIAN EDUCATION IN THE 19th – EARLY 20th CENTURIES
Authors:   Central Russian Institute of Management, branch of RANEPA, LUPANDIN V.N. 
Published: October 2022

The purpose of the article is to analyze the place and role of logic as an academic discipline in the aspect of reforming Russian education in the 19th – early 20th centuries. The author draws attention to the fact that the scope of the study is the reforming of Russian education in the 19th – early 20th centuries and the subject of the study is the idea of the place and role of logic as an educational discipline in this process. As a result, the author draws conclusions that	the research results can be used by studying the humanities as well as they can be applied in order to improve the ways of thinking of representatives of society and those of the public administration in relation to society, politics and the system of state and municipal administration.
Evolution of the T1D Exchange Quality Improvement Collaborative (T1DX-QI): Using Real-World Data and Quality Improvement to Advance Diabetes Outcomes
Authors: Majidi Shideh , Rioles Nicole , Agarwal Shivani , Ebekozien Osagie 
Published: October 2022

<p> </p>
<p>The T1D Exchange Quality Improvement Collaborative (T1DX-QI) is a framework used to systematically improve systems and processes. It was established in 2016 and has continued to evolve throughout the past 6 years (Figure 1). In health care settings, the T1DX-QI allows health care professionals, patients with type 1 diabetes, and families to be part of a process that evaluates and improves many areas of health care for everyone who touches the health care system (1). Learning health systems (LHSs) are systems in which “science, informatics, incentives, and culture are aligned for continuous improvement and innovation” (2). T1DX-QI is an LHS that is real-world data–enabled and now includes more than 45 pediatric and adult sites (Figure 2 and Supplementary Table S1). The T1DX-QI special article collection in this issue of <em>Clinical Diabetes </em>highlights T1DX-QI’s continued expansion and contributions to diabetes care. </p>
Moderne ortodokse kirker
Authors: Bodin Per-Arne 
Published: October 2022

Moderne ortodokse kirker har blivit både inaktuell och ohyggligt aktuell i och med den ryska invasionen av Ukraina 24 februari 2022, då frågor om olika ortodoxa samhörigheter kommit i fokus. Volymen består nio kapitel och behandlar nästan samtliga stora ortodoxa kyrkor i världen och många centrala frågor som nationalism, jurisdiktion, teologi och gudstjänstutövning. Boken är pålitlig när det gäller fakta, författarna är eminent kunniga, men den kan ibland bli en smula svårläst i all sin faktarikedom.
The volume has become both outdated and eerily topical after the Russian invasion of Ukraine on 24 February 2022, as issues concerning various Eastern Orthodox affiliations have come into focus. This nine-chapter volume deals with almost all major Orthodox Churches in the world, and takes up such central questions such as nationalism, jurisdiction, theology and worship. The book is a reliable source of information, and the authors are eminently competent, but the sheer mass of facts presented can make it somewhat difficult to read.
DEVELOPMENT OF DIGITAL COMIC AS A BIOLOGY LEARNING MEDIA
Authors: Damanik Monika Sari Dewi , Sipahutar Herbert 
Published: October 2022

This study aims to develop and test the feasibility of digital comic-based learning media and to examine its effect on student’s learning outcome in cell material. Learning media was developed according to the 4D development model of Thiagarajan which consisted of four stages, namely define, design, develop and disseminate. Media was validated by contentl expert, media expert, and learning expert. The suggestion from biology teacher and students of class XI MIA 2 SMA Negeri 2 Percut Sei Tuan were asked. The data of study were obtained through validation instruments, questionnaires, and cognitive test. Data were analyzed qualitatively and quantitatively. The result of the study showed that the developed comic media was considered very feasible by material expert (94,38%), media expert (89,34%), and learning expert (96,00%). Comic was considered very feasible too both by biology teachers (93.22%) and by students (92.38%). The results of the paired sample t-test on the pre-test and post-test score of 0.00 > 0.05 indicate that the post-test score is bigger than the pre-test score. The data showed that the result of cognitive test had increased significantly after using the developed digital comic media.
Formulasi dan Evaluasi Blush on Compact powder Ekstrak Daging Buah Naga (Hylocereus polyrhizus) sebagai Coloring Agent
Authors: Butar-Butar Maria Elvina Tresia , Sianturi Sister , Fajar Fahrudin Gozali 
Published: October 2022

Maraknya peggunaan pewarna sintetik yang berbahaya pada sediaan kosmetika sudah sangat mengkhawatirkan. Oleh sebab itu, pentingnya dilakukan penelitian untuk menghasilkan kosmetika dengan pewarna alami yang tidak berbahaya. Buah naga (Hylocereus polyrhizus) merupakan salah satu buah yang memiliki kandungan antosianin yang berperan penting untuk menghasilkan warna. Tujuan penelitian ini adalah memanfaatkan kandungan antosianin pada daging buah naga sebagai coloring agent pada salah satu sediaan kosmetika, yaitu blush on compact powder. Metode penelitian yang dilakukan secara eksperimental, meliputi ekstraksi daging buah naga dengan metode maserasi menggunakan etanol 96%, pembuatan sediaan blush on dengan lima konsentrasi ekstrak daging buah naga yang berbeda, yaitu 10% (F1), 15% (F2), 20% (F3), 25% (F4), dan 30% (F5). Pemeriksaan mutu fisik blush on, meliputi uji organoleptis, uji homogenitas, uji poles, uji pH, uji keretakkan, uji stabilitas, uji iritasi, dan uji hedonik/kesukaan terhadap sediaan. Hasil penelitian menunjukkan bahwa sediaan blush on dengan konsentrasi 10% berwarna merah muda sangat pucat, 15% berwarna merah muda pucat, 20% merah muda, 25% berwarna merah muda cerah, dan 30% berwarna merah muda sangat cerah. Semakin tinggi konsentrasi ekstrak yang digunakan, maka akan semakin cerah intensitas warna yang dihasilkan. pH sediaan blush on masih memenuhi interval pH fisiologis, yaitu 4,5-6,5. Blush on tidak menunjukkan adanya keretakan saat dijatuhkan, stabil selama penyimpanan, dan tidak menyebabkan iritasi kulit. Uji hedonik sediaan blush on yang paling banyak disukai oleh responden adalah blush on dengan konsentrasi 30% karena mudah digunakan dengan pemolesan satu kali telah menghasilkan intensitas warna merah muda yang menarik. Kesimpulan dari penelitian ini adalah ekstrak etanol daging buah naga dapat dimanfaatkan sebagai coloring agent pada sediaan blush on. Kata kunci: Kosmetika, blush on, compact powder, Hylocereus polyrhizus
Cervical Cyst – A Tale of the Unexpected
Authors: Vlahov Y. , Mollova E. , Vidinov K. , Mateva G. , Mladenov M. , Bochev P. , Borissova A. M. 
Published: October 2022

Abstract
Primary hyperparathyroidism (PHPT) is the third most common endocrine disease after diabetes and osteoporosis. It is more common in women and its prevalence increases with age. PHPT is associated with parathyroid adenoma or cancer or paraneoplastic parathyroid hormone (PTH) production. PHPT can be asymptomatic or present with nephrolithiasis, peptic ulcers, pancreatitis, bone lesions and rarely – as a palpable formation in the cervical area. We present a 73-year-old female patient with cystic cervical lesion with high levels of PTH in the evacuated fluid contents. We discuss the differential diagnosis and the diagnostic algorhythm in cystic cervical lesions.