bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cyclic interaction between daytime behavior and the sleep behavior of laboratory dogs
Authors: Schork Ivana Gabriela , Manzo Isabele Aparecida , De Oliveira Marcos Roberto Beiral , da Costa Fernanda Vieira , Young Robert John , de Azevedo Cristiano Schetini 
Published: January 2022

AbstractSleep deprivation has been found to negatively affect an individual´s physical and psychological health. Sleep loss affects activity patterns, increases anxiety-like behaviors, decreases cognitive performance and is associated with depressive states. The activity/rest cycle of dogs has been investigated before, but little is known about the effects of sleep loss on the behavior of the species. Dogs are polyphasic sleepers, meaning the behavior is most observed at night, but bouts are also present during the day. However, sleep can vary with ecological and biological factors, such as age, sex, fitness, and even human presence. In this study, kennelled laboratory adult dogs’ sleep and diurnal behavior were recorded during 24-h, five-day assessment periods to investigate sleep quality and its effect on daily behavior. In total, 1560 h of data were analyzed, and sleep metrics and diurnal behavior were quantified. The relationship between sleeping patterns and behavior and the effect of age and sex were evaluated using non-parametric statistical tests and GLMM modelling. Dogs in our study slept substantially less than previously reported and presented a modified sleep architecture with fewer awakenings during the night and almost no sleep during the day. Sleep loss increased inactivity, decreased play and alert behaviors, while increased time spent eating during the day. Males appeared to be more affected by sleep fragmentation than females. Different age groups also experienced different effects of sleep loss. Overall, dogs appear to compensate for the lack of sleep during the night by remaining inactive during the day. With further investigations, the relationship between sleep loss and behavior has the potential to be used as a measure of animal welfare.
Intensive production of the harpacticoid copepod Tigriopus californicus in a zero-effluent ‘green water’ bioreactor
Authors: Prado-Cabrero Alfonso , Herena-Garcia Rafael , Nolan John M. 
Published: January 2022

AbstractAquaculture is looking for substitutes for fishmeal and fish oil to maintain its continued growth. Zooplankton is the most nutritious option, but its controlled mass production has not yet been achieved. In this context, we have developed a monoalgal ‘green water’ closed-loop bioreactor with the microalgaeTetraselmis chuithat continuously produced the harpacticoid copepodTigriopus californicus. During 145 days of operation, the 2.2 m3bioreactor produced 3.9 kg (wet weight) ofTigriopuswith (dry weight) 0.79 ± 0.29% eicosapentaenoic acid (EPA), 0.82 ± 0.26% docosahexaenoic acid (DHA), 1.89 ± 0,60% 3S,3’S-astaxanthin and an essential amino acid index (EAAI) of 97% for juvenile Atlantic salmon. The reactor kept the pH stable over the operation time (pH 8.81 ± 0.40 in the algae phase and pH 8.22 ± 2.96 in the zooplankton phase), while constantly removed nitrate (322.6 mg L−1) and phosphate (20.4 mg L−1) from the water. As a result of the stable pH and nutrient removal, the bioreactor achieved zero effluent discharges. The upscaling of monoalgal, closed-loop ‘green water’ bioreactors could help standardize zooplankton mass production to supply the aquafeeds industry.
The significant role of post-pairing male behavior on the evolution of male preferences and female traits
Authors: Lyu Nan , Yeh D. Justin , Lloyd Huw , Sun Yue-Hua 
Published: January 2022

AbstractExisting sexual selection theory postulates that a sufficiently large variation in female fecundity or other direct benefits are fundamental for generating male mate choice. In this study, we suggest that, in addition to pre-pairing preferences, choosy males can also have different post-pairing behaviors, a factor which has been comparatively overlooked by previous studies. We found that both male preferences and female traits could evolve much more easily than previously expected when the choosy males that paired with unpreferred females would allocate more efforts to seeking additional post-pairing mating opportunities. Furthermore, a costly female trait could evolve when there was a trade-off between seeking additional mating and paternal care investment within social pair for choosy males. Finally, a costly male preference and a costly female trait might still evolve and reach a stable polymorphic state in the population, which might give rise to a high variability in male choice and female traits in nature. We suggest that male mate choice may be even more common than expected, which needs to be verified empirically.
Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment
Authors: Le Le Thi My , Thompson James Robert , Dang Phuoc Xuan , Bhandari Janarjan , Alam Amer 
Published: January 2022

AbstractThe peroxisomal very long chain fatty acid (VLCFA) transporter ABCD1 is central to fatty acid catabolism and lipid biosynthesis. Its dysfunction underlies toxic cytosolic accumulation of VLCFAs, progressive demyelination, and neurological impairments including X-linked adrenoleukodystrophy (X-ALD). We present cryo-EM structures of ABCD1 in phospholipid nanodiscs in a nucleotide bound conformation open to the peroxisomal lumen and an inward facing conformation open to the cytosol at up to 3.5 Å resolution, revealing details of its transmembrane cavity and ATP dependent conformational spectrum. We identify features distinguishing ABCD1 from its closest homologs and show that coenzyme A (CoA) esters of VLCFAs modulate ABCD1 activity in a species dependent manner. Our data suggest a transport mechanism where the CoA moieties of VLCFA-CoAs enter the hydrophilic transmembrane domain while the acyl chains extend out into the surrounding membrane bilayer. The structures help rationalize disease causing mutations and may aid ABCD1 targeted structure-based drug design.
Emergence of energy-avoiding and energy-seeking behaviors in nonequilibrium dissipative quantum systems
Authors: Werlang Thiago , Matos Maurício , Brito Frederico , Valente Daniel 
Published: January 2022

AbstractA longstanding challenge in nonequilibrium thermodynamics is to predict the emergence of self-organized behaviors and functionalities typical of living matter. Despite the progress with classical complex systems, it remains far from obvious how to extrapolate these results down to the quantum scale. Here, we employ the paradigmatic master equation framework to establish that some lifelike behaviors and functionalities can indeed emerge in elementary dissipative quantum systems driven out of equilibrium. Specifically, we find both energy-avoiding (low steady dissipation) and energy-seeking behaviors (high steady dissipation), as well as self-adaptive shifts between these modes, in generic few-level systems. We also find emergent functionalities, namely, a self-organized thermal gradient in the system’s environment (in the energy-seeking mode) and an active equilibration against thermal gradients (in the energy-avoiding mode). Finally, we discuss the possibility that our results could be related to the concept of dissipative adaptation.
Identification of pathological subtypes of early lung adenocarcinoma based on artificial intelligence parameters and CT signs
Authors: Fang Weiyuan , Zhang Guorui , Yu Yali , Chen Hongjie , Liu Hong 
Published: January 2022

Abstract
Objective: To explore the value of quantitative parameters of artificial intelligence (AI) and computed tomography (CT) signs in identifying pathological subtypes of lung adenocarcinoma appearing as ground-glass nodules (GGNs). Methods: CT images of 224 GGNs from 210 individuals were collected retrospectively and classified into atypical adenomatous hyperplasia (AAH)/adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC) groups. AI was used to identify GGNs and to obtain quantitative parameters, and CT signs were recognized manually. The mixed predictive model based on logistic multivariate regression was built and evaluated. Results: Of the 224 GGNs, 55, 93, and 76 were AAH/AIS, MIA, and IAC, respectively. In terms of AI parameters, from AAH/AIS to MIA, and IAC, there was a gradual increase in two-dimensional mean diameter, three-dimensional mean diameter, mean CT value, maximum CT value, and volume of GGNs (all P&lt;0.0001). Except for the CT signs of the location, and the tumor–lung interface, there were significant differences among the three groups in the density, shape, vacuolar signs, air bronchogram, lobulation, spiculation, pleural indentation, and vascular convergence signs (all P&lt;0.05). The areas under the curve (AUC) of predictive model 1 for identifying the AAH/AIS and MIA and model 2 for identifying MIA and IAC were 0.779 and 0.918, respectively, which were greater than the quantitative parameters independently (all P&lt;0.05). Conclusion: AI parameters are valuable for identifying subtypes of early lung adenocarcinoma and have improved diagnostic efficacy when combined with CT signs.
Toward Empowering Conversational Agency in Aphasia: Understanding Mechanisms of Topic Initiation in People With and Without Aphasia
Authors: Leaman Marion C. , Archer Brent , Edmonds Lisa A. 
Published: January 2022

Purpose:This study examined topic initiation (TI) in conversations involving people with aphasia (PWA), matched people without aphasia (M-PWoA), and speech-language pathologists who were their conversation partners (SLP-Ps). For each speaker type, we analyzed patterns of distribution of typical mechanisms of TI and patterns of simultaneous use of multiple TI mechanisms. Lastly, we examined associations between use of simultaneous TI mechanisms and communicative success.Method:Twenty PWA and 20 M-PWoA each participated in two conversations with SLP-Ps. Conversation samples were analyzed for TI locations and mechanisms, with results tallied for each speaker type following a published typology. A measure of communicative success was applied to TI utterances. Rank-order correlations were conducted to evaluate the patterns of distribution of the TI mechanisms between speaker types and the patterns of multiple mechanism usage between speaker types. Descriptive analysis was conducted to provide additional insight to the TI behaviors of each speaker type and to evaluate the relationship between multiple TI mechanisms and communicative success.Results:All speaker types used cohesion most often to achieve TI. PWA used an abrupt method of TI (noncoherent TI) more often than other speaker types. A single mechanism of TI was used most often by all speaker types, except for SLP-Ps when they were in conversations with PWA. In this case, SLP-Ps most often used two or more layered mechanisms of TI. SLP-Ps also used a highly salient TI mechanism with greater frequency when speaking with PWA than observed between other speaker types. When PWA layered mechanisms of TI, they appeared to be more likely to achieve better communicative success.Conclusions:Specific, teachable behaviors such as favoring certain TI mechanisms and using multiple TI mechanisms may improve communicative success during TI for PWA. Furthermore, findings suggest that SLP-Ps modify their TI behaviors when speaking to PWA.Supplemental Material:https://doi.org/10.23641/asha.17699423
What is the role of inflammatory markers in predicting spontaneous ureteral stone passage?
Authors: Senel Cagdas , Aykanat Ibrahim Can , Asfuroglu Ahmet , Keten Tanju , Balci Melih , Aslan Yilmaz , Tuncel Altug 
Published: January 2022

Abstract
Purpose: To investigate the role of inflammatory markers in predicting the spontaneous passage of ureteral stones.
Methods: We retrospectively reviewed 279 patients with ureteral
stones sized 4–10 mm that were managed conservatively. The patients were divided into two
groups: Group 1 consisted of 137 patients who passed the stone spontaneously; Group 2
comprised 142 patients without spontaneous stone passage. The groups were compared using the
Mann-Whitney U and chi-square tests. In addition, univariate and multivariate analyses were
performed to identify the significance of the parameters.
Results: The mean age of the patients was 41.2 years. The patients in Group 1 had a significantly lower mean stone size, white blood cell count and neutrophil count. In addition, stone location, presence of hydronephrosis and history of urolithiasis were significantly different between the groups. Neutrophil percentage, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were insignificantly lower in Group 1. In a multivariate analysis, stone size, distal location and hydronephrosis status significantly predicted the spontaneous stone passage. However, inflammatory markers including white blood cell count, neutrophil count and neutrophil-to-lymphocyte ratio could not determine the likelihood of spontaneous stone passage.
Conclusion: Our results suggest that inflammatory markers are no meaningful parameters for the prediction of spontaneous stone passage.
Osteopetrosis in a Patient of Systemic Sclerosis Sine Scleroderma: A Rare Association
Authors: Pati Saroj K. , Raja Praveen , Behera Ajoy K. , Ranganath T.G. , Bodhey Narendra K. 
Published: January 2022

AbstractSystemic sclerosis is a connective tissue disorder of unknown etiology. Although it is a multisystemic disorder, skin thickening is considered as a hallmark of the disease. It usually involves the lungs, gastrointestinal, and musculoskeletal systems. However, a rare subset of systemic sclerosis, systemic sclerosis sine scleroderma, is characterized by internal organ involvement and positive serologic markers with the total or partial absence of cutaneous manifestations. We present a rare association of osteopetrosis in a case of systemic sclerosis sine scleroderma, in a 22-year-old male patient, who presented with pulmonary symptoms as his chief complaints, unreported so far in literature.
Prevalence of Latent Autoimmune Diabetes in Adult Based on the Presence of GAD 65 Antibodies in North-Eastern Uttar Pradesh, India
Authors: Sangma Himalina , Singh Anshul , Srivastava Anubha , Misra Vatsala 
Published: January 2022

Objective
The objective of this paper was (1) to study the prevalence of latent autoimmune diabetes in adult (LADA) in the region of north-eastern Uttar Pradesh, India, based on the positivity for glutamic acid decarboxylase 65 (GAD65) antibodies and (2) to compare the glycemic profile between GAD65-positive and GAD65-negative subjects.

Materials and Methods
The subjects were of more than 30 years of age, with either recently diagnosed pre-diabetes/diabetes presenting with the hemoglobin A1c (HbA1c) level of ≥5.7% or already diagnosed cases of type 2 diabetes mellitus (T2DM) who had no requirement of insulin therapy for at least 6 months from the time of their diagnosis. All the patients were natives of north-eastern Uttar Pradesh. The GAD65 test was done by the enzyme-linked immunosorbent assay. Further, the glycemic status of GAD-positive and GAD-negative subjects were compared on the basis of fasting blood sugar (FBS), fasting insulin (FI), and homeostatic model assessment for insulin resistance (HOMA-IR). The “unpaired t-test” was used to compare and assess the significance of differences between the glycemic profile of GAD65-positive and GAD65-negative subjects using the GraphPad Prism Scientific Software, San Diego, CA, United States. The p-value of <0.05 was considered to be significant.

Results
A total of 77 patients were included in the study, with the age group ranging from 30 to 75 years (47.81 ± 12.9 years) with the male–female ratio of 1:2.6. The prevalence of LADA was found to be 51.95%. On comparing GAD65-positive and GAD65-negative groups, a higher value of HbA1c levels and FBS were found in the former, whereas FI and HOMA-IR were found to be higher in the latter. On testing for significance of difference, only FI and HbA1c values were significant (p-value <0.0001).

Conclusion
LADA can no longer be considered a rare type of diabetes mellitus, with the present study showing a high prevalence of LADA in this north eastern region of Uttar Pradesh. Identification of adult-onset diabetics accurately as LADA or true T2DM is very crucial for the appropriate treatment, as LADA patients require insulin inevitably and much earlier than true T2DM patients, who can be managed mostly on oral hypoglycemic agents with seldom requirement of insulin.
First Carpometacarpal Joint Anatomy and Osteoarthritis: MR Imaging Overview
Authors: Kamalasekar Kanagasabai , Ravikanth Reddy 
Published: January 2022

AbstractThe first carpometacarpal (CMC) joint consists of seven ligaments. The magnetic resonance imaging (MRI) examination of the first CMC joint should be performed in a high field 1.5/3 T MRI with a dedicated hand coil for high-resolution images. Degeneration of anterior oblique ligament (AOL) is the most important cause for the development of osteoarthritis of first CMC joint. Since the AOL undergoes a predictable pattern of alteration at its metacarpal attachment as degeneration proceeds, MRI imaging can provide an accurate assessment of this ligament.
Use of Artificial Intelligence to Triage Patients with Flu-Like Symptoms Using Imaging in Non-COVID-19 Hospitals during COVID-19 Pandemic: An Ongoing 8-Month Experience
Authors: Kapoor Atul , Kapoor Aprajita , Mahajan Goldaa 
Published: January 2022

Abstract
Background Evaluation of suspected coronavirus disease-2019 (COVID-19) patient is a diagnostic dilemma as it commonly presents like influenza in early stages. Studies and guidelines have emerged both for and against the use of imaging as a frontline tool to investigate such patients. Reverse transcriptase-polymerase chain reaction (RT-PCR) is suggested as the backbone of diagnosis. We designed and tested a diagnostic algorithm using artificial intelligence (AI) to determine the role of imaging in the evaluation of patients with acute flu-like presentation.
Materials and Methods Overall, 3,235 consecutive patients with flu-like presentation were evaluated over a period of 240 days. All patients underwent plain radiographs of chest with computer-aided detection for COVID-19 (CAD4COVID) AI analysis. Based on the threshold scores, they were divided into two groups: group A (score < 50) and group B (score > 50). Group A patients were discharged and put on routine symptomatic treatment and follow-up with RT-PCR, while group B patients underwent high-resolution computed tomography (HRCT) followed by COVID-19 AI analysis and RT-PCR test. These were then triaged into COVID-19 and non-COVID-19 subgroups based on COVID-19 similarity scores by AI, and lung severity scores were also determined.
Results Group A had 2,209 (68.3%) patients with CAD4COVID score of <50 while 1,026 (31.7%) patients comprised group B. Also, 825 (25.5%) patients were COVID-19 positive with COVID-19 similarity threshold of >0.85 on AI. RT-PCR was positive in 415 and false-negative in 115 patients while 12 patients died before the test could be done. The sensitivity and specificity of CAD4COVID AI analysis on plain radiographs for detection of any lung abnormality combined with HRCT AI analysis was 97.9% and 99% using the above algorithm.
Conclusion Combined use of chest radiographs and plain HRCT with AI-based analysis is useful and an accurate frontline tool to triage patients with acute flu-like symptoms in non-COVID-19 health care facilities.
Pediatric Electrical Bicycle Road Accidents
Authors: Avrahamov-Kraft Ethel , Yulevich Alon , Sweed Yechiel 
Published: January 2022

AbstractIntroduction The use of electric bicycles (EBs) among children younger than 18 years of age is rapidly increasing worldwide and becoming a substantial contributor to road accidents. We analyzed patterns and severity of pediatric bicycle-related injuries, comparing children riding EBs and classic bicycles (CBs).Materials and Methods This was a retrospective study (January 2016–December 2018) of patients arriving at our medical center due to a bicycle accident. Data were collected from medical records and included demographics, injury characteristics, treatment, and outcomes.Results Of 561 children, 197 (35%) were EB riders and 364 (65%) were CB riders. Injury severity score (ISS) of EB cyclists was significantly higher than CB cyclists (mean 4.08 ± 4.67 and 3.16 ± 2.84, respectively, p = 0.012). The rate of accidents involving motorized vehicles was higher in the EB versus CB group (25.9 vs. 11.3%, p < 0.001). Head injuries were the most common type of injury in both groups; incidence was higher in CB than in EB cyclists. However, loss of consciousness was more common in the EB group (18.3 and 12.1%, respectively, p = 0.057). Lower extremity injuries were more common in EBs versus CBs (55.8 and 37.6%, respectively, p < 0.001). Orthopaedic surgical interventions were significantly higher in the EB group (49.2 vs. 33.2%, p < 0.001), and length of stay in hospital and admission to pediatric intensive care unit were more common in EB compared with CB, although not significantly.Conclusion Injury severity of EB patients was significantly higher than that of CB patients. Accidents involving motorized vehicles were more common in the EB group. Head injury associated with loss of consciousness was significantly higher in EB patients.
Odontogenic-Like Pain in Partial Edentulism: An Unusual Presentation of Diffuse Large B-Cell Lymphoma of the Mandible
Authors: Catania Roberta , Belloni Elena , Preda Lorenzo , Bortolotto Chandra , Scagnelli Paola , Calliada Fabrizio 
Published: January 2022

AbstractPrimary bone lymphoma is a rare entity and it usually occurs in long bones. Primary mandibular involvement is very rare, and it usually shows unspecific features, mimicking odontogenic inflammatory lesions. We present the unusual case of a diffuse large B-cell lymphoma (DLBCL) of the right mandibular body in a 91-year-old woman, who presented with acute pain in the mandibular region initially suspicious for odontogenic abscess. No significant findings were seen on orthopantomography (OPG) and her almost complete edentulism made the diagnosis of abscess unlikely. Computed tomography and magnetic resonance images showed an expansive mass around the right mandibular body with erosion of cortical bone and involving the right mandibular canal and nerve. Final diagnosis of DLBCL was pathologically proven. The presence of odontogenic-like pain in nearly complete edentulism should be suspicious for malignancy, and it needs further diagnostic workup despite the absence of signs on OPG.