bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Model Pembelajaran Kooperatif Tipe Jigsaw untuk Meningkatkan Hasil Belajar IPA Siswa
Authors: Asmara Dedi 
Published: October 2022

The purpose of this study was to determine the increase in learning outcomes of science material special characteristics of living animals using jigsaw learning methods in grade VI students of SD Negeri 06 Sialang, Kapur IX District, Lima Puluh Kota District. This research is an experimental research in the form of Classroom Action Research (CAR) with the subjects in this study being class VI students totaling 24 students. Data collection techniques in this study are; (1) observation of teacher activity, (2) observation of student activity, and (3) test of learning outcomes. Based on the results of the study found an increase in the average value of the class of research subjects rose from the pre-cycle average value of 74.16, cycle I 79.58 to 87.08 in cycle II and PTK was considered successful. Conclusions, based on the results of the study, the jigsaw method can improve science learning achievement in grade VI students with special characteristics of animal living things in SD Negeri 06 Sialang, Kapur IX District, Lima Puluh Kota.
Keywords: Learning Outcomes, Cooperative Learning Methods, Jigsaw Learning
Strategi Guru Agama Desa dalam Meningkatkan Kemampuan Membaca Al-Qur’a Warga Desa
Authors: Joni Rama , Rahman Abdul , Yanuarti Eka 
Published: October 2022

This study aims to explore and find out the strategies of village religious teachers in improving the ability to read the Koran of Turan Baru villagers especially those aged 40 years and older. By using descriptive qualitative writing methods, data obtained using interviews and observations. The informants in this study were religious teachers and students studying the Koran in the village of Turan Baru. The results of the study obtained information that there are several strategies implemented by the Turan Baru Village Religion Teachers to improve the students' ability to read the Qur'an, namely; routine recitation; strategies for listening and correcting santri readings during recitation; motivate students in learning to read the Qur'an. The listening strategy used by village religious teachers is still quite effective in improving the ability to read Al-Qur'an of pilgrims who are above the age of 40 years and above, because when there is an error the teacher can immediately correct the mistakes of the congregation. Conclusions, methods and listening strategies in reading the Qur'an in the village of Turan Baru is one way to improve the ability to read the Qur'an, this strategy also increases the enthusiasm of learning of the congregation, which will eventually bring the congregation the better in reading the Qur'an with the correct reading rules.
Keywords: Strategy, Village Religion Teachers, Al-Qur'an Reading Ability
Treatment of a ruptured blister aneurysm of the left internal carotid artery with telescoping Pipeline Flex embolization devices with Shield Technology
Authors: Budohoski Karol P. , Rennert Robert C. , Mortimer Vance , Couldwell William T. , Grandhi Ramesh 
Published: October 2022

Ruptured blister aneurysms have significant rates of morbidity and mortality, but evidence of positive results with use of flow-diverting stents such as the Pipeline embolization device (PED) is growing. The authors describe the staged endovascular treatment of a ruptured left internal carotid artery blister aneurysm in a patient with a Hunt and Hess grade IV subarachnoid hemorrhage. PED placement was done via the common femoral artery using a triaxial delivery system. The telescoping stent technique performed over 48–72 hours achieved sufficient coverage of the aneurysm neck while limiting treatment time during the acute presentation and allowing interim dual antiplatelet treatment. A staged approach allows the targeting of a second PED placement in patients whose aneurysm continues to fill on the first follow-up angiogram. The authors have not experienced increased thromboembolic complications with this approach. Complete occlusion was achieved by postbleed day 8.
The video can be found here: https://stream.cadmore.media/r10.3171/2022.7.FOCVID2264
تدوين التاريخ الإسلامي عند السنة والشيعة
Authors: Zwain Qassim Khalaf Salman , Abed Al-Mohammadi Hussein 
Published: October 2022

يمكن القول إن الاتجاهات في قراءة التاريخ وتدوينه لأية أمّة من الأمم تتعدّد بتعدّد الغايات والتحزّبات في تلك الأمّة، فإنّ تعدّد الحركات السياسية والمذاهب الدينية والولاءات القومية والمصالح الشخصية يوجب تعدّد الاتجاهات والقراءات للواقعة الواحدة، ويحتّم الاختلاف في النظر والرؤية لتلك الحادثة، ومن ثمّ في تحليلها وتفسيرها، بل في تصديقها والأخذ بها أو تكذيبها والإعراض عنها.
فالمادة التاريخية وكيفيّة قراءتها وتأويلها غالبا ما تكون مثارا للخلاف والتباين بين أصحاب التوجهات المختلفة؛ فكلّ – حسب العادة والطبيعة البشرية - يقرأ التاريخ ويدوّنه بما يوافق معتقده ومذهبه.
ولم يكن تاريخنا الإسلامي بمنأى عن ذلك، فقد تعدّدت قراءاته وتباينت أحداثه؛ بحسب توجهات المؤرّخين وأهوائهم، وانعكاس التحيّزات والانتماءات السياسية والمذهبية على ما سطّرت أقلامهم، وكان حصيلة ذلك عدم التمكّن من معرفة تاريخنا الإسلامي كما كان، ولم يصلنا إلا تاريخ مشوّش مضطرب، لا يكاد يصمد أمام النقد والفحص، ولا يقاوم أمام التنقيب والبحث، يَحكي ويُخبر عن سيرة كلّ مَنْ تربّع على كرسيّ الحكم والخلافة، وكلّ مَنْ حَكَمَ باسم رسول الله صلّى الله عليه وآله مهما كانت نواياه وغاياته، فيعطي عناية خاصة لتاريخ الخلفاء والملوك، ويُغضي ويتعامى عن الخط الرسالي الأصيل المتمثّل بالقادة الربانيين الذين نصبهم رسول الله صلّى الله عليه وآله لحفظ الرسالة وصيانتها من التحريف، والذين تفرّدوا بكتابة التاريخ الإسلامي على أصوله، من دون زيف وتشويه، ولا مصانعة وتحريف، بالرغم من حظر السلطات الحاكمة للتدوين، والضغط الذي كانت تمارسه على الصحابة والتابعين.
ويمكن القول ان الاتجاهات الإسلامية في كتابة التاريخ، منها: ما أكل عليه الدهر وشرب، ومنها: ما اندمج وانصهر في غيره، وعلى ضوء ذلك لم يبق - اليوم - الا اتجاهين رئيسيين مختلفين متفاوتين في قراءة التاريخ وتدوينه، لكلّ منهما أسلوبه ومنهجه، ومتبنياته وثوابته.
الاتجاه الأول لأهل السنة والجماعة، او مدرسة الحكم والخلافة، حيث انطلقوا من فكرة أن الصحابة يمثّلون المصدر الوحيد والواسطة التي تربط بينهم وبين النبيّ الأكرم صلّى الله عليه وآله، فحكموا بعدالة جميع الصحابة، ولزوم الأخذ عنهم من دون بحث وتحقيق، وعدم جواز الجرح والتعديل في حقّهم، ولا السؤال عن عدالتهم، بل أنه أمر مفروغ منه.
والاتجاه الثاني لأتباع مدرسة أهل البيت عليهم السلام، حيث اعتقدوا بأنّ أئمّة أهل البيت عليهم السلام مُنَصّبون من قبل الله سبحانه بعد النبيّ الأكرم صلّى الله عليه وآله، ووجوب اتّباعهم، والأخذ عنهم، وتقديمهم على جميع الصحابة بدون استثناء.
وهناك اتجاه ثالث يمثّله المستشرقون، وله انعكاسات قد تكون خطيرة في بعض جوانبه على تقديم التاريخ الإسلامي وروايته، لا دخل له بنظرة المسلمين الى الغاية والهدف من كتابة التاريخ الإسلامي، بل لهم دوافعهم وغاياتهم وأهدافهم الخاصة.
وسوف نركّز في هذا البحث على خصوص القواعد التي كان لها تأثير وفاعليّة في تصنيف المؤرّخين المسلمين الى هذين الاتجاهين؛ اتجاه أهل السنّة والجماعة واتجاه أتباع أهل البيت عليهم السلام؛ وذلك لأن القواعد العامة في كتابة التاريخ العام والتاريخ الإسلامي بالخصوص قواعد مشتركة غالبا؛ لا خلاف فيها إلا في بعض الجزئيات والتفسيرات التي يتبنّاها هذا الاتجاه أو ذاك.
The pleiotropic role of melatonin against chromium-induced cardiovascular infirmities: a mechanistic insight
Authors: Ghosh Priyanka , Dey Tiyasa , Bandyopadhyay Debasish 
Published: October 2022

Currently, cardiovascular diseases are still the number one killer in the world. These include hypertension, coronary heart disease, ischemic heart disease, myocardial infarction, congestive heart failure, cardiac arrhythmias, etc. One of the risk factors for cardiovascular diseases is environmental heavy metal pollution which makes the victims more vulnerable to sudden cardiac death. Chromium (Cr) is one of the metals. Cr(VI) is the most hazardous one among its variants. It is readily across the plasma membrane to cause oxidative damage to intracellular molecules including LDL, proteins, and DNA; therefore, promotes endothelial dysfunction and Ca2+ overload in the heart. As to its molecular mechanism, Cr(VI) downregulates the expressions of SIRTUINS, FOXOs, PGC-1α, and AMPK and upregulates the P53, Akt, and NF-κβ, causing alteration in metabolic pathways, inhibiting mitochondrial biogenesis, inducing autophagy and apoptosis. In addition, Cr(VI) alters the expressions of Th1 cytokines (IL-1β, IL-2, IL-12, TNF-α, and IFN-γ) as well as Th2 cytokines (IL-4, IL-5, and IL-10) to induce myocardial inflammation. Melatonin, a potent antioxidant, and an efficient metal chelator can neutralize almost all the alterations caused by Cr(VI). Thus, melatonin can be a selected molecule to protect against Cr(VI)-induced cardiovascular toxicity. This review highlights the etiology of Cr(VI) associated heart diseases and the potentiality of melatonin to prevent Cr(VI)-mediated cardiac oxidative stress, apoptosis and inflammation.
Nutrients Changed the Assembly Processes of Profuse and Rare Microbial Communities in Coals
Authors: Zhang Yuanyuan , Xue Sheng , Chang Xiaohua , Li Yang , Yue Xuelian 
Published: October 2022

Abstract
Nutrient stimulation is considered effective for improving biogenic coalbed methane production potential. However, our knowledge of the microbial assembly process for profuse and rare microbial communities in coals under nutrient stimulation is still limited. This study collected 16S rRNA gene data from 59 microbial communities in coals for a meta-analysis. Among these communities, 116 genera were identified as profuse taxa, and the remaining 1,637 genera were identified as rare taxa. Nutrient stimulation increased the Chao1 richness of profuse and rare genera and changed the compositions of profuse and rare genera based on nonmetric multidimensional scaling with Bray-Curtis dissimilarities. In addition, many profuse and rare genera belonging to Proteobacteria and Acidobacteria were reduced, whereas those belonging to Euryarchaeota and Firmicutes were increased under nutrient stimulation. Concomitantly, the microbial co-occurrence relationship network was also altered by nutrient addition, and many rare genera mainly belonging to Firmicutes, Bacteroides, and Euryarchaeota also comprised the key microorganisms. In addition, the compositions of most of the profuse and rare genera in communities were driven by stochastic processes, and nutrient stimulation increased the relative contribution of dispersal limitation for both profuse and rare microbial community assemblages and that of variable selection for rare microbial community assemblages. In summary, this study strengthened our knowledge regarding the mechanistic responses of coal microbial diversity and community composition to nutrient stimulation, which are of great importance for understanding the microbial ecology of coals and the sustainability of methane production stimulated by nutrients.
Genome-Guided Investigation Provides New Insights into Secondary Metabolites of Streptomyces parvulus SX6 from Aegiceras corniculatum
Authors: Quach Ngoc Tung , Nguyen Vu Thi Hanh , Bui Thi Lien , Pham Anh Tuan , An Nguyen Thi Thu , Xuan Le Thi Thanh , Thuy Ta Thi Thu , Dudhagara Pravin , Phi Quyet-Tien 
Published: October 2022

Abstract
Whole-genome sequencing and genome mining are recently considered an efficient approach to shine more light on the underlying secondary metabolites of Streptomyces. The present study unearths the biosynthetic potential of endophytic SX6 as a promising source of biologically active substances and plant-derived compounds for the first time. Out of 38 isolates associated with Aegiceras corniculatum (L.) Blanco, Streptomyces parvulus SX6 was highly active against Pseudomonas aeruginosa ATCC® 9027™ and methicillin-resistant Staphylococcus epidermidis (MRSE) ATCC® 35984™. Additionally, S. parvulus SX6 culture extract showed strong cytotoxicity against Hep3B, MCF-7, and A549 cell lines at a concentration of 30 μg/ml, but not in non-cancerous HEK-293 cells. The genome contained 7.69 Mb in size with an average G + C content of 72.8% and consisted of 6,779 protein-coding genes. AntiSMASH analysis resulted in the identification of 29 biosynthetic gene clusters (BGCs) for secondary metabolites. Among them, 4 BGCs showed low similarity (28–67% of genes show similarity) to actinomycin, streptovaricin, and polyoxypeptin gene clusters, possibly attributed to antibacterial and anticancer activities observed. In addition, the complete biosynthetic pathways of plant-derived compounds, including daidzein and genistein were identified using genome mining and HPLC-DAD-MS analysis. These findings portray an exciting avenue for future characterization of promising secondary metabolites from mangrove endophytic S. parvulus.
Comparative Genome Analysis of a Novel Alkaliphilic Actinobacterial Species Nesterenkonia haasae
Authors: Wang Shuang , Sun Lei , Narsing Rao Manik Prabhu , Fang Bao‑zhu , Li Wen‑jun 
Published: October 2022

Abstract
In the present study, a comparative genome analysis of the novel alkaliphilic actinobacterial Nesterenkonia haasae with other members of the genus Nesterenkonia was performed. The genome size of Nesterenkonia members ranged from 2,188,008 to 3,676,111 bp. N. haasae and Nesterenkonia members of the present study encode the essential glycolysis and pentose phosphate pathway genes. In addition, some Nesterenkonia members encode the crucial genes for Entner-Doudoroff pathways. Some Nesterenkonia members possess the genes responsible for sulfate/thiosulfate transport system permease protein/ ATP-binding protein and conversion of sulfate to sulfite. Nesterenkonia members also encode the genes for assimilatory nitrate reduction, nitrite reductase, and the urea cycle. All Nesterenkonia members have the genes to overcome environmental stress and produce secondary metabolites. The present study helps to understand N. haasae and Nesterenkonia members’ environmental adaptation and niches specificity based on their specific metabolic properties. Further, based on genome analysis, we propose reclassifying Nesterenkonia jeotgali as a later heterotypic synonym of Nesterenkonia sandarakina.
The m6A-methylated mRNA pattern and the activation of the Wnt signaling pathway under the hyper-m6A-modifying condition in the keloid
Authors: Lin Can-Xiang , Chen Zhi-Jing , Peng Qi-Lin , Xiang Ke-Rong , Xiao Du-Qing , Chen Ruo-Xi , Cui Taixing , Huang Yue-Sheng , Liu Hong-Wei 
Published: October 2022

Purpose: The present study was carried out to investigate the global m6A-modified RNA pattern and possible mechanisms underlying the pathogenesis of keloid.Method: In total, 14 normal skin and 14 keloid tissue samples were first collected on clinics. Then, three samples from each group were randomly selected to be verified with the Western blotting to determine the level of methyltransferase and demethylase. The total RNA of all samples in each group was isolated and subjected to the analysis of MeRIP sequencing and RNA sequencing. Using software of MeTDiff and htseq-count, the m6A peaks and differentially expressed genes (DEGs) were determined within the fold change &gt;2 and p-value &lt; 0.05. The top 10 pathways of m6A-modified genes in each group and the differentially expressed genes were enriched by the Kyoto Encyclopedia of Genes and Genomes signaling pathways. Finally, the closely associated pathway was determined using the Western blotting and immunofluorescence staining.Results: There was a higher protein level of WTAP and Mettl3 in the keloid than in the normal tissue. In the keloid samples, 21,020 unique m6A peaks with 6,573 unique m6A-associated genetic transcripts appeared. In the normal tissue, 4,028 unique m6A peaks with 779 m6A-associated modified genes appeared. In the RNA sequencing, there were 847 genes significantly changed between these groups, transcriptionally. The genes with m6A-methylated modification and the upregulated differentially expressed genes between two tissues were both mainly related to the Wnt signaling pathway. Moreover, the hyper-m6A-modified Wnt/β-catenin pathway in keloid was verified with Western blotting. From the immunofluorescence staining results, we found that the accumulated fibroblasts were under a hyper-m6A condition in the keloid, and the Wnt/β-Catenin signaling pathway was mainly activated in the fibroblasts.Conclusion: The fibroblasts in the keloid were under a cellular hyper-m6A-methylated condition, and the hyper-m6A-modified highly expressed Wnt/β-catenin pathway in the dermal fibroblasts might promote the pathogenesis of keloid.
Design, synthesis, and insecticidal activity of a novel series of flupyrimin analogs bearing 1-aryl-1H-pyrazol-4-yl subunits
Authors: Zhao Fenghai , Tang Xianjun , Huang Jiaxing , Li Jiaqi , Xiao Yumei , Qin Zhaohai 
Published: October 2022

To discover new potential insecticides to protect agricultural crops from damage, a series of novel flupyrimin derivatives containing an arylpyrazole core were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR, and HRMS. Bioassays indicated that the 31 compounds synthesized possessed excellent insecticidal activity against Plutella xylostella. Among these target compounds, the lethality of A3, B1-B6, D4, and D6 reached 100% at 400 μg/ml. Moreover, when the concentration dropped to 25 μg/ml, the insecticidal activities against the Plutella xylostella for compounds B2, B3, and B4 still reached more than 70%. The structure–activity relationship of the Plutella xylostella was discussed. The density functional theory analysis of flupyrimin and B4 was carried out to support the abovementioned structure–activity relationship. The possible binding modes between receptor and active groups in title compounds were also verified by docking simulation. These results provided new ideas for the development of these novel candidate insecticides in the future.
40Ar/39Ar ages and geochemistry of the Intersalar Range of the Bolivian Altiplano: A volcanological transect spanning the arc and reararc of the Central Andean Plateau
Authors: Salisbury Morgan J. , Jiménez Néstor , Barfod Dan 
Published: October 2022

The volcanic Intersalar Range of western Bolivia provides a unique opportunity to examine geochemical variations spanning the arc and reararc regions of the Central Andean Plateau. In this study we report 23 new 40Ar/39Ar ages, 15 whole-rock Sr-Nd-Pb isotope analyses, and 50 whole-rock major and trace element analyses from samples collected across ∼115 km of the Intersalar Range. Most samples are classified as trachyandesites and trachydacites, with the most mafic lavas (slightly alkaline, basaltic trachyandesites) erupting from the Pliocene Coracora volcano in the central Altiplano. We identify two distinct pulses of reararc magmatism: a Miocene phase between 20 Ma and 14 Ma that corresponds with local compressional shortening, and a Plio-Pleistocene phase between 5 and 1 Ma that postdates observed structural deformation in the region. 87Sr/86Sr values (0.70512–0.70600) and 143Nd/144Nd values (0.51226–0.51255) are generally higher, and lower, respectively, in the younger phase, whereas Pb isotopes (206Pb/204Pb = 17.7315–18.5095; 207Pb/204Pb = 15.5714–15.6279; 208Pb/204Pb = 37.7862–38.6156) show little variation with age. Isotope values are only loosely correlated with distance from the modern Central Volcanic Zone. Higher Sr/Y, Dy/Yb, and [La/Yb]N values in the Plio-Pleistocene samples are consistent with homogenization at the base of a thicker continental crust compared to the Miocene samples. Nb concentrations show the strongest correlation with distance into the reararc compared to all other trace elements (arc Nb = 6–16 ppm; reararc Nb = 12–26 ppm). Nb/Nb* values (a measurement of the depth of the negative Nb anomaly) correspondingly increase into the reararc (indicating smaller anomalies), reaching a maximum at Coracora volcano before decreasing in the far rear arc region. Compiled data across the Central Andean Plateau reveal a strong correlation between Nb/Nb* and the presence of intact mantle lithosphere beneath the central Altiplano. We interpret this distinct Nb signal to reflect melting triggered by the breakdown of Nb-rich hydrous minerals within foundering (delaminating) mantle lithosphere. In conjunction with spatiotemporal data, Nb systematics provide the clearest indication of mantle lithosphere in regions where mafic samples are not present.
The mechanism of Girdin in degenerative brain disease caused by high glucose stimulation
Authors: Liu Longteng , Zhang Jinsong , Han Yanxi , Liu Dongge 
Published: October 2022

Girdin, as an actin-binding protein, plays a major role in maintaining the stability of the actin skeleton structure and affects the growth, development, and migration of neurons. This study discusses the mechanism of Girdin in brain degeneration caused by high glucose stimulation. We examined the expression of Girdin in diabetic patients. The positive expression rate of Girdin in the diabetic group was 17.2% (5/29), which was obviously lower than the positive expression rate of 83.3% (20/24) in the non-diabetic group. We examined the expression of Girdin and its signaling pathway-related proteins Akt and STAT3 in hippocampal neurons induced by high glucose. The results showed that, in contrast to the control group (glucose concentration = 25 mmol/L), the expression of Girdin in the high-glucose group (glucose concentration = 225 mmol/L) was reduced (P &lt; 0.05); the phosphorylation levels of Akt and STAT3 related to Girdin signaling pathway were also reduced (P &lt; 0.05). Under high-glucose stimulation, the structure of neurons is abnormal, such as the reduction or disappearance of dendritic spines, and the number of neurons is reduced. In addition, Girdin and Akt were less expressed in neurons and synapses, especially the most obvious reduction in synaptic terminals. The activity of Girdin and its signaling pathway-related proteins Akt and STAT3 decreased in neurons under high glucose stimulation, indicating that the mechanism of Girdin in brain degeneration caused by high glucose stimulation was closely related to the Akt and STAT3 pathways.Graphic AbstractThe mechanism of Girdin in degenerative brain disease caused by high glucose stimulation. This article discusses the mechanism of Girdin in brain degeneration induced by high glucose stimulation. The expression of Girdin in the diabetic group was significantly lower than that in the non-diabetic group. The expression of Girdin and its signaling pathway-related proteins Akt and STAT3 in hippocampal neurons was significantly reduced under high glucose stimulation. Under high glucose stimulation, the structure of neurons is abnormal and the number decreases; synapses become shorter. It indicates that the mechanism of brain degeneration caused by high glucose stimulation by Girdin is closely related to the Akt and STAT3 pathways.