bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pituitary Abscess as Manifestation of IgG4-Related Hypophysitis: A Case Report
Authors: Salvati Lorenzo , Tinghi Francesco , Ammannati Franco , Buccoliero Anna Maria , Parronchi Paola , Trotta Michele , Cammelli Daniele 
Published: July 2022

Abstract
IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition with heterogeneous organ-specific manifestations. IgG4-related hypophysitis results from pituitary involvement and represents a rare neuro-ophthalmic complication of IgG4-RD, but the presentation as pituitary abscess is exceptional. We report the case of a 38-year-old otherwise healthy woman with a 3-year history of relapsing pituitary sterile abscess repeatedly treated with neurosurgery and antimicrobials. Histological re-examination of pituitary biopsy specimens revealed a dense inflammatory infiltrate rich in IgG4-positive plasma cells. Serum IgG4 levels were normal and circulating plasmablasts were increased. A diagnosis of IgG4-related hypophysitis was made and the patient treated with high-dose steroid pulse therapy with subsequent reduction of the pituitary lesion and resolution of symptoms. This case highlights how the diagnostic intuition on the basis of histopathology has changed management with prompt dramatic response to steroid therapy.
Still Loving the F-Word
Authors: Brunner Claudia 
Published: July 2022

ZusammenfassungIntersektionale feministische Theorie unterschiedlicher disziplinärer Provenienz hat wichtige Vorarbeit für heute diskutierte post- und dekoloniale Theorie geleistet. Feministische Friedens- und Konfliktforschung kann als Vermittlerin zwischen diesen Perspektiven und der eigenen Disziplin fungieren. In meinem Beitrag schlage ich vor, das für das Konzept der kolonialen Moderne zentrale Begriffspaar des epistemischen Rassismus/Sexismus, das von früheren marxistisch-feministischen Arbeiten geprägt ist, zum Ausgangspunkt für eine herrschaftskritische Wiederbelebung der Friedens- und Konfliktforschung zu machen. Ausgehend vom post- und dekolonialen Befund, dass der Zustand der Kolonialität bis heute anhält und das kapitalistische Weltsystem und seine vielfältigen Gewaltpraktiken aufrechterhält, muss die Friedens- und Konfliktforschung ihren eigenen Euro- und Androzentrismus bearbeiten und ihre Verortung auf dem epistemischen Territorium der Moderne einer Kritik unterziehen. Ausgehend davon kann sie globale Macht‑, Gewalt- und Herrschaftsverhältnisse wieder in einen glaubwürdigen herrschaftskritischen Blick bekommen. Feministische Perspektiven, die im Zentrum meiner Argumentation stehen, leisten für diese Grundlagenforschung einen wichtigen Beitrag.
Towards big data behavioral analysis: rethinking GPS trajectory mining approaches from geographic, semantic, and quantitative perspectives
Authors: Huang Weixin , Wang Luying 
Published: July 2022

AbstractThe question regarding the actual usage of built environments is of immense importance in behavioral research. Yet traditional methods of collecting and analyzing data on movements and activities often lack needed accuracy and granularity. Thus, this article reviewed and summarized the applicability of emergent GPS trajectory mining approaches in the field of architecture from geographic, semantic, and quantitative perspectives, respectively. Accordingly, three experiments based on a case study using real GPS trajectory data from visitors to the Palace Museum in China were conducted to examine the usefulness and weakness of the aforementioned approaches. The findings revealed that although all three dimensions of the trajectory mining approaches had the potential to provide useful information for architectural and urban design, the higher the dimensionality in utilizing the data, the more effective the approach was in discovering generalizable knowledge of human behavioral pattern. Furthermore, the results suggested that to gain insights into the typological characteristics of human behaviors related to the built environments, the contribution of trajectory data alone was limited, hence, conventional field surveys and questionnaires which contain information on individual characteristics and spatial features should be used in conjunction. Future research and practical implications were outlined.
Sexual Wellness Outcomes Associated with Experiences of Stealthing
Authors: Jones H , Bogen KW , Lorenz TK 
Published: July 2022

ABSTRACT

Introduction
Sexual violence is alarmingly common and associated with negative health outcomes, including higher rates of sexually transmitted infections, greater likelihood of substance misuse, and poorer sexual functioning. More than one-third of men report using coercive condom use resistance tactics – including nonconsensual condom removal (i.e., “stealthing”) – to obtain unprotected sex. Women who experience stealthing report less confidence in refusing unwanted sexual advances and less sexual agency, which may increase risk for future victimization and reduced sexual wellbeing overall. While much work has linked other forms of sexual violence to sexual dysfunction, little is known about sexual functioning in the context of stealthing, which limits the utility of clinical interventions to improve survivors’ sexual wellness and prevent revictimization.

Objective
To analyze the relationships between a history of stealing and correlates of sexual functioning and wellness.

Methods
We surveyed 265 women from a large university in the Midwestern U.S. (Mage = 19.8) and ran linear models assessing the relationship between any history of stealthing and sexual wellness correlates including sexual pleasure, functioning, desire, arousal, lubrication, orgasm, satisfaction, pain, shame, pleasure deservingness, and assertiveness. All models controlled for participants’ lifetime number of sexual partners.

Results
Overall, the effects of stealthing were strongest in women with more lifetime sexual partners. A history of stealthing was significantly and positively associated with solitary and partnered pleasure, sexual desire, arousal, lubrication, and feelings of pleasure deservingness. Notably, sexual shame was the only associated negative outcome.

Conclusions
Results suggest the relationship between a history of stealthing and greater reported sexual wellness may be a function of greater exposure to sexual activity overall. Increased exposure to sexual activity is related to increased communication about sexual needs and desires. It is possible that sexual shame was uniquely correlated with stealthing because stealthing may be viewed as a more ambiguous form of sexual violence by survivors and thereby increase risk for survivors’ self-blame. Alternatively, increased sexual shame may be related to reduced sexual self-efficacy and thus increase risk for victimization. Future analyses should examine specific contexts in which stealthing is associated with increased sexual distress and potential mediators such as sensation-seeking and positive coping skills. Overall, these results highlight the need for further research and increased communication on coercive condom use resistance tactics and their relation to sexual correlates, in particular, sexual shame.

Disclosure
No
A Qualitative Study of Women's Experiences with Hypoactive Sexual Desire Disorder in the United States
Authors: Lim-Watson M , Kallich J , Murimi-Worstell I , Kingsberg S , Hays R 
Published: July 2022

ABSTRACT

Introduction
Hypoactive Sexual Desire Disorder (HSDD) significantly impacts a woman's daily functioning and well-being (health-related quality of life, HRQoL) and is often undetected by the medical profession and dismissed by society. As a result, the profound and extensive impact of HSDD on the lives of women and their partners is underappreciated.

Objective
This qualitative study was conducted to identify defining symptoms and HRQoL impacts among women with HSDD.

Methods
Six virtual focus groups (90-minutes each) were conducted with 30 adult women to understand HSDD symptoms and HRQoL impacts. Two trained focus group moderators utilized a semi-structured interview guide to capture spontaneous and stated symptoms and impacts. All focus groups were transcribed verbatim, anonymized, coded by two independent researchers using Atlas.ti 9, and then analyzed employing a combination of semi-quantitative and qualitative data analytic methods to evaluate saturation. Elicited content was used to further refine a literature-derived HRQoL conceptual model of HSDD.

Results
A total of 15 pre-menopausal and 15 post-menopausal women participated in the focus groups between October 14 and 21, 2020. Participants reported a total of 10 symptom concepts during the focus group, including loss of spontaneous desire, sexual distress, disinterest in initiating sex, disinterest in engaging in sex, absence of pleasure, little to no sexy feelings, feeling asexual, sexual avolition, vaginal pain, and insomnia. The most frequently reported symptoms were loss of spontaneous desire (n=30, 100%) and sexual distress (n=23, 77%). A total of 41 impact concepts associated with HSDD across 9 domains were reported: partner impact, mental well-being, role functioning, social functioning, familial relationships, appearance, concentration, and overall quality of life and satisfaction with life. Women reported impairment to their mental well-being (n=30, 100%), partner relationship (n=29, 97%), overall quality of life (n=29, 97%), and life satisfaction (n=29, 97%), as well as described feeling stigmatized by healthcare providers, friends, and society as a whole (n=27, 90%). A literature-based conceptual model for HSDD was updated to reflect focus group results.

Conclusions
Women with HSDD report many relevant, important, and meaningful concepts that are inadequately evaluated in research and drug trials. HSDD profoundly and negatively impacts women's HRQoL. Greater awareness of these concepts, and the availability of HRQoL measures that accurately reflect symptoms and impacts are needed to “destigmatize” and improve medical care for women with HSDD.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: AMAG Pharmaceuticals, Inc., Astellas, Dare, Duchesnay, Ovoca, Field Trip, Palatin Technologies, Pfizer, Materna, Maddora, TherapeuticsMD, Strategic Science Technologies, and Lupin.
What's Preventing Healthcare Providers from Screening for Female Sexual Dysfunction?
Authors: VanDommelen K , Kasper R , McCarter M , Connors N , Davenport S 
Published: July 2022

ABSTRACT

Introduction
Female sexual dysfunction (FSD) significantly decreases qualify of life and the prevalence of FSD increases with age.(1) It is known that many healthcare providers do not screen for sexual dysfunction due to discomfort, not having enough time, or not having enough knowledge on the subject.(2) However the overall incidence of FSD will continue to increase as our postmenopausal population continues to grow. It is estimated that by the year of 2025 there will be 1.1 billion postmenopausal women worldwide.(3) Women in this age group often rely on their family medicine or internal medicine physician as the gatekeeper for their healthcare needs.(4) Therefore, healthcare providers both within the field of obstetrics and gynecology and general practitioners need to be prepared to screen, diagnose, and treat FSD.

Objective
The purpose of this study is to add to the current gaps in literature regarding screening for sexual dysfunction. Our goal is to identify what barriers exist to screening for sexual dysfunction across different fields. Identifying barriers by field will allow for targeted interventions to increase the screening, diagnosis, and treatment of female sexual dysfunction.

Methods
This study was based on a questionnaire that was distributed to healthcare providers practicing at an academic institution via email. The email was distributed as a one-time survey via residency programs across the country. Descriptive statistics were performed to assess study characteristics.

Results
220 physicians and advanced practice providers completed the survey. 182 within the field of OBGYN completed the survey and 38 within the field of family or internal medicine completed the survey. Our results found that while 59% of providers responded they are screening for sexual dysfunction, only 5% of providers surveyed overall reported that they always screen for FSD. Of those not screening for FSD, the primary reason for OBGYNs is not feeling that they have enough time (22%) compared to other specialties reporting lack of knowledge about FSD (67%). Of those who stated they screened for FSD, 45% stated they were not familiar with any screening tool or questionnaires.

Conclusions
OBGYNs, Internal Medicine, and Family Medicine providers have room to improve screening for FSD. Our study shows that the primary barrier reported by OBGYNs related to time constraints, whereas other primary care providers reported not having enough knowledge. Future studies should focus on interventions for these two respective barriers.

Disclosure
No
Alterations in infant gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME technology
Authors: Mesnage Robin , Calatayud Marta , Duysburgh Cindy , Marzorati Massimo , Antoniou Michael N. 
Published: July 2022

Abstract
Despite extensive research into the toxicology of the herbicide glyphosate, there are still major unknowns regarding its effects on the human gut microbiome. We describe the effects of glyphosate and a Roundup glyphosate-based herbicide on infant gut microbiota using SHIME technology. SHIME microbiota culture was undertaken in the presence of a concentration of 100-mg/L glyphosate and the same glyphosate equivalent concentration of Roundup. Roundup and to a lesser extent glyphosate caused an increase in fermentation activity, resulting in acidification of the microbial environment. This was also reflected by an increase in lactate and acetate production concomitant to a decrease in the levels of propionate, valerate, caproate and butyrate. Ammonium production reflecting proteolytic activities was increased by Roundup exposure. Global metabolomics revealed large-scale disturbances, including an increased abundance of long-chain polyunsaturated fatty acids. Changes in bacterial composition measured by qPCR and 16S rRNA suggested that lactobacilli had their growth stimulated as a result of microenvironment acidification. Co-treatment with the spore-based probiotic formulation MegaSporeBiotic reverted some of the changes in short-chain fatty acid levels. Altogether, our results suggest that glyphosate can exert effects on human gut microbiota.
The impact of talent management on ethical behavior and intention to stay in the organization
Authors: Luna-Arocas Roberto , Danvila-del-Valle Ignacio 
Published: July 2022

AbstractWhat has been called the war for talent in companies has become a key element in organizations that want to be competitive. Talent management has already been studied and verified in terms of its impact on performance and productivity, and this has led to more and more research generating a professional and scientific interest with other variables, such as ethical behavior. In the present study it is verified, through a model of structural equations, that the organizations that apply strategies of talent management have more ethical behaviors and intention to stay. Talent management and ethical behavior would reinforce work environments, by restoring confidence in the organization. Likewise, talent management implies greater loyalty of talent, that is an antecedent of the intention to stay in the organization.
Kounis syndrome following allergy injection in a paediatric patient
Authors: Mason Maria , Campbell Matthew D. 
Published: July 2022

AbstractKounis syndrome is the concurrence of acute coronary syndrome or coronary vasospasm with conditions associated with the release of inflammatory cytokines through mast cell activation in the setting of allergic or anaphylactic reactions. Many identified triggers have been identified in paediatric patients including exposures, drugs, and immunisations; however, to our knowledge this is the first case report of Kounis syndrome linked to immunotherapy. We present a case of a 9-year-old with seasonal allergies presenting with clinical symptoms of Kounis syndrome following her weekly subcutaneous injection of allergens. Clinicians need a high index of suspicion for Kounis syndrome in patients who develop systemic signs of anaphylaxis with clinical, laboratory, electrocardiographic, and echocardiographic findings of acute coronary syndrome to help direct therapy and improve outcomes.
Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3
Authors: Lacey Heather J. , Chen Rachel , Vuong Daniel , Fisher Mark F. , Lacey Ernest , Rutledge Peter J. , Piggott Andrew M. 
Published: July 2022

AbstractAmycolatopsis sp. MST-135876 was isolated from soil collected from the riverbank of El Pont de Suert, Catalonia, Spain. Cultivation of MST-135876 on a range of media led to the discovery of a previously unreported dichlorinated cyclic hexapeptide, suertide A (d-Ser, 5-Cl-d-Trp, 6-Cl-d-Trp, l-Ile, d-Val, d-Glu), featuring an unprecedented pair of adjacent 5/6-chlorotryptophan residues. Supplementing the growth medium with KBr resulted in production of the mono- and dibrominated analogues suertides B and C, respectively. Suertides A–C displayed selective activity against Bacillus subtilis (MIC 1.6 µg ml−1) and Staphylococcus aureus (MIC 3.1, 6.3, and 12.5 µg ml−1, respectively), while suertides A and B showed appreciable activity against methicillin-resistant S. aureus (MIC 1.6 and 6.3 µg ml−1, respectively).
Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration
Authors: Senabouth Anne , Daniszewski Maciej , Lidgerwood Grace E. , Liang Helena H. , Hernández Damián , Mirzaei Mehdi , Keenan Stacey N. , Zhang Ran , Han Xikun , Neavin Drew , Rooney Louise , Lopez Sanchez Maria Isabel G. , Gulluyan Lerna , Paulo Joao A. , Clarke Linda , Kearns Lisa S. , Gnanasambandapillai Vikkitharan , Chan Chia-Ling , Nguyen Uyen , Steinmann Angela M. , McCloy Rachael A. , Farbehi Nona , Gupta Vivek K. , Mackey David A. , Bylsma Guy , Verma Nitin , MacGregor Stuart , Watt Matthew J. , Guymer Robyn H. , Powell Joseph E. , Hewitt Alex W. , Pébay Alice 
Published: July 2022

AbstractThere are currently no treatments for geographic atrophy, the advanced form of age-related macular degeneration. Hence, innovative studies are needed to model this condition and prevent or delay its progression. Induced pluripotent stem cells generated from patients with geographic atrophy and healthy individuals were differentiated to retinal pigment epithelium. Integrating transcriptional profiles of 127,659 retinal pigment epithelium cells generated from 43 individuals with geographic atrophy and 36 controls with genotype data, we identify 445 expression quantitative trait loci in cis that are asssociated with disease status and specific to retinal pigment epithelium subpopulations. Transcriptomics and proteomics approaches identify molecular pathways significantly upregulated in geographic atrophy, including in mitochondrial functions, metabolic pathways and extracellular cellular matrix reorganization. Five significant protein quantitative trait loci that regulate protein expression in the retinal pigment epithelium and in geographic atrophy are identified - two of which share variants with cis- expression quantitative trait loci, including proteins involved in mitochondrial biology and neurodegeneration. Investigation of mitochondrial metabolism confirms mitochondrial dysfunction as a core constitutive difference of the retinal pigment epithelium from patients with geographic atrophy. This study uncovers important differences in retinal pigment epithelium homeostasis associated with geographic atrophy.
Role of gradient nanograined surface layer on corrosion behavior of aluminum 7075 alloy
Authors: Beura V. K. , Karanth Y. , Darling K. , Solanki K. 
Published: July 2022

AbstractGradient nano-grained structures have been a promising technique to evade the strength-ductility trade-off in metals and alloys. Therefore, in this work, the effect of surface mechanical attrition treatment (SMAT) on the microstructure and corrosion behavior of the high-strength aluminum alloy was investigated. SMAT was performed at room temperature and liquid-nitrogen (LN2) flow conditions to generate two distinctly different initial gradient microstructures. Potentiodynamic polarization, electrochemical impedance spectroscopy, and intergranular corrosion tests were performed. Surface film characterization of untreated and treated samples was performed using X-ray photoelectron spectroscopy and time of flight secondary ion mass spectroscopy techniques. Result reveals significant microstructural changes in SMAT processed samples such as the formation of precipitates and dissolution of inherent phases. In addition, a reduced anodic dissolution rate was observed with the SMAT processed samples. Furthermore, the surface film characterization revealed a thicker oxide film with Cu and SiO2 enrichment in SMAT samples.
A curated binary pattern multitarget dataset of focused ATP-binding cassette transporter inhibitors
Authors: Stefan Sven Marcel , Jansson Patric Jan , Pahnke Jens , Namasivayam Vigneshwaran 
Published: July 2022

AbstractMultitarget datasets that correlate bioactivity landscapes of small-molecules toward different related or unrelated pharmacological targets are crucial for novel drug design and discovery. ATP-binding cassette (ABC) transporters are critical membrane-bound transport proteins that impact drug and metabolite distribution in human disease as well as disease diagnosis and therapy. Molecular-structural patterns are of the highest importance for the drug discovery process as demonstrated by the novel drug discovery tool ‘computer-aided pattern analysis’ (‘C@PA’). Here, we report a multitarget dataset of 1,167 ABC transporter inhibitors analyzed for 604 molecular substructures in a statistical binary pattern distribution scheme. This binary pattern multitarget dataset (ABC_BPMDS) can be utilized for various areas. These areas include the intended design of (i) polypharmacological agents, (ii) highly potent and selective ABC transporter-targeting agents, but also (iii) agents that avoid clearance by the focused ABC transporters [e.g., at the blood-brain barrier (BBB)]. The information provided will not only facilitate novel drug prediction and discovery of ABC transporter-targeting agents, but also drug design in general in terms of pharmacokinetics and pharmacodynamics.
Mathematical analysis of hybrid mediated blood flow in stenosis narrow arteries
Authors: Hussain Azad , Sarwar Lubna , Rehman Aysha , Al Mdallal Qasem , Almaliki Abdulrazak H. , El-Shafay A. S. 
Published: July 2022

AbstractIn this paper the behavior of flow of blood under stenosis suppositions is studied. Nanoparticles of Ag and Cu are being used with blood as base fluid. The problem governing equations are modeled into PDE’s, which are transformed into set of ODE’s with the help of useful similarity transformation. We investigated the solution numerically for various parameters on temperature and velocity distribution and shown in the form of tables and graphs. It is found that the velocity of blood increases while the temperature curve goes down by increasing the concentration of nanoparticles and also temperature curve decreases by increasing the values of gamma and Prandtl number. Furthermore, the calculated results shows that increment in flow parameter gamma caused an increase in velocity values. In the field of biomedicine, the important approach of nanotechnology is the use of nanoparticles in chemotherapy.