bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sickle cell cerebrovascular reactivity to a CO2 stimulus: Too little, too slow
Authors: Forté Stéphanie , Sobczyk Olivia , Poublanc Julien , Duffin James , Hare Gregory M. T. , Fisher Joseph Arnold , Mikulis David , Kuo Kevin H. M. 
Published: August 2022

Background: Despite increased cerebral blood flow (CBF), cerebral infarcts occur in patients with sickle cell disease (SCD). This suggests increased CBF does not meet metabolic demand possibly due to compromised cerebral vasodilatory response. Hypothesis: In adult SCD patients, cerebrovascular reactivity (CVR) and speed of vasodilatory response (tau) to a standardized vasodilatory stimulus, are reduced compared to normal subjects.Methods: Functional brain imaging performed as part of routine care in adult SCD patients without known large vessel cerebral vasculopathy was reviewed retrospectively. CVR was calculated as the change in CBF measured as the blood-oxygenation-level-dependent (BOLD)-magnetic resonance imaging signal, in response to a standard vasoactive stimulus of carbon dioxide (CO2). The tau corresponding to the best fit between the convolved end-tidal partial pressures of CO2 and BOLD signal was defined as the speed of vascular response. CVR and tau were normalized using a previously generated atlas of 42 healthy controls.Results: Fifteen patients were included. CVR was reduced in grey and white matter (mean Z-score for CVR −0.5 [−1.8 to 0.3] and −0.6 [−2.3 to 0.7], respectively). Tau Z-scores were lengthened in grey and white matter (+0.9 [−0.5 to 3.3] and +0.8 [−0.7 to 2.7], respectively). Hematocrit was the only significant independent predictor of CVR on multivariable regression.Conclusion: Both measures of cerebrovascular health (CVR and tau) in SCD patients were attenuated compared to normal controls. These findings show that CVR represents a promising tool to assess disease state, stroke risk, and therapeutic efficacy of treatments in SCD and merits further investigation.
Effects of footwear with different longitudinal bending stiffness on biomechanical characteristics and muscular mechanics of lower limbs in adolescent runners
Authors: Chen Hairong , Shao Enze , Sun Dong , Xuan Rongrong , Baker Julien S. , Gu Yaodong 
Published: August 2022

Background: Running shoes with carbon plates have been identified to have positive effects on improving running performance from a biomechanical perspective. However, the specific difference between the effects of carbon plates with different longitudinal bending stiffness (LBS)on biomechanical characteristics and muscular mechanics of lower limbs in adolescent runners remains unclear. This study aimed to identify the difference in biomechanical characteristics and muscular mechanics in lower limbs during running stance phases between wearing shoes with low longitudinal bending stiffness (Llbs) and high longitudinal bending stiffness (Hlbs) carbon plates in adolescent runners.Methods: 10 male adolescent runners with a habit of daily running exercise (age: 13.5 ± 0.6 years; height: 166.3 ± 1.9 cm; bodyweight: 50.8 ± 3.1 kg; foot length: 25.4 ± 0.2 cm) were recruited and asked to conduct two times of tests by wearing shoes with Llbs and Hlbs carbon plates in a randomized order. Paired t-test and statistical parametric mapping (SPM) analysis were used to identify the difference in biomechanical characteristics and muscular mechanics in lower limbs during running stance phases.Result: Under the condition of wearing shoes with Hlbs, the time of foot contact significantly increased, whereas the range of motion (ROM) of hip and metatarsophalangeal (MTP) in the sagittal plane significantly reduced as well as the peak moment of ankle joint in the sagittal plane. The activations of vastus medialis, vastus lateralis, flexor digitorum brevis (flex dig brevis), and flexor hallucis longus (flex hall long) significantly increased under the condition of wearing shoes with Hlbs. According to the results of the SPM analysis, the joint angles (hip, ankle, and MTP), the net joint moments (knee, ankle, and MTP), and the muscle forces (gluteus maximus and tibialis anterior) were significant difference during the running stance phase between conditions of wearing shoes with Hlbs and Llbs.Conclusion: Running shoes with Llb carbon plates are appropriate for adolescent runners due to the advantages of biomechanical characteristics and muscular mechanics.
Compensatory effects of different exercise durations on non-exercise physical activity, appetite, and energy intake in normal weight and overweight adults
Authors: Liu Xiao-Mei , Wang Ke , Zhu Zheng , Cao Zhen-Bo 
Published: August 2022

Objectives: To examine compensatory changes of different exercise durations on non-exercise physical activity (NEPA), appetite, and energy intake (EI) in normal and overweight adults, and to determine if different body mass index of individuals interact with these compensatory effects.Methods: Ten normal weight adults (nine females and one male; age: 24.0 ± 0.4 years; BMI: 20.7 ± 0.5 kg/m2) and ten overweight adults (six females and four males; age: 24.5 ± 0.9 years; BMI: 25.9 ± 0.4 kg/m2) participated in this study. The participants completed two exercise trials: short-duration continuous training (SDCT) and long-duration continuous training (LDCT), i.e., a 40 min short-duration and an 80 min long-duration continuous training in a randomized order. Total physical activity and NEPA were monitored using an accelerometer for seven consecutive days, which involved a two-day baseline observation period (C-pre-Ex), three-day exercise intervention period (Ex), and two-day follow-up period (C-post-Ex). Blood samples were collected for appetite-related hormone analysis. Appetite score was assessed using the visual analogue scale. Energy intake was evaluated by weighing the food and recording diaries.Results: The NEPA evaluation showed that it was higher for SDCT than for LDCT in the C-post-Ex period (F (1, 19) = 8.508, p = 0.009) in the total sample. Moreover, results also indicated that NEPA was lower for LDCT (F (2, 18) = 6.316, p = 0.020) and higher for SDCT (F (2, 18) = 3.889, p = 0.026) in the C-post-Ex period than in the C-pre-Ex and Ex periods in overweight group. Acyl-ghrelin revealed a main effect of time in the total sample and in normal weight and overweight groups; it was lower in the C-post-Ex period than in the C-pre-Ex and Ex periods (all p &lt; 0.05). Total EI analysis revealed no significant changes in either the total sample or in the normal weight and overweight groups.Conclusion: These findings demonstrate that short duration exercise led to a compensatory increment in NEPA, whereas long duration exercise induced a compensatory decrease in NEPA. Moreover, there was a higher and delayed compensatory response in overweight adults than in normal weight adults. Nevertheless, energy intake was not changed across time, regardless of exercise duration.
The impact of potentially modifiable risk factors for stroke in a middle-income area of China: A case-control study
Authors: Wu Yuhang , Chen Xiaoyun , Hu Songbo , Zheng Huilie , Chen Yiying , Liu Jie , Xu Yan , Chen Xiaona , Zhu Liping , Yan Wei 
Published: August 2022

AimsTo reveal the impact of eleven risk factors on stroke and provide estimates of the prevention potential.MethodsWe completed a multicenter case-control study in Jiangxi, China, a middle-income area. Neuroimaging examination was performed in all cases. Controls were stroke-free adults recruited from the community in the case concentration area. Conditional logistic regression and unconditional logistic regression were used for subgroup analysis of stroke type, and other groups (sex, age and urban-rural area), respectively. Odds ratios (ORs) and their population attributable risks (PARs) were calculated, with 95% confidence intervals.ResultsA total of 43,615 participants (11,735 cases and 31,880 controls) were recruited from February to September 2018, of whom we enrolled 11,729 case-control pairs. Physical inactivity [PAR 69.5% (66.9–71.9%)] and hypertension [53.4% (49.8–56.8%)] were two major risk factors for stroke, followed by high salt intake [23.9% (20.5–27.3%)], dyslipidemia [20.5% (17.1–24.0%)], meat-based diet [17.5% (14.9–20.4%)], diabetes [7.7% (5.9–9.7%)], cardiac causes [5.3% (4.0–6.7%)], alcohol intake [4.7% (0.2–10.0%)], and high homocysteine [4.3% (1.4–7.4%)]. Nine of these factors were associated with ischemic stroke, and five were associated with intracerebral hemorrhage. Collectively, eleven risk factors accounted for 59.9% of the PAR for all stroke (ischemic stroke: 61.0%; intracerebral hemorrhage: 46.5%), and were consistent across sex (men: 65.5%; women: 62.3%), age (≤55: 65.2%; &gt;55: 63.5%), and urban-rural areas (city: 62.2%; county: 65.7%).ConclusionThe 11 risk factors associated with stroke identified will provide an important reference for evidence-based planning for stroke prevention in middle-income areas. There is an urgent need to improve awareness, management and control of behavioral and metabolic risk factors, particularly to promote physical activity and reduce blood pressure.
Urine metabolomics analysis of sleep quality in deep-underground miners: A pilot study
Authors: Wen Qiao , Zhou Jing , Sun Xiaoru , Ma Tengfei , Liu Yilin , Xie Yike , Wang Ling , Cheng Juan , Wen Jirui , Wu Jiang , Zou Jian , Liu Shixi , Liu Jifeng 
Published: August 2022

BackgroundIn previous questionnaire surveys of miners, sleep disorders were found among underground workers. The influence of the special deep-underground environment and its potential mechanism are still unclear. Therefore, this study intends to utilize LC-MS metabolomics to study the potential differences between different environments and different sleep qualities.MethodsTwenty-seven miners working at 645–1,500 m deep wells were investigated in this study, and 12 local ground volunteers were recruited as the control group. The Pittsburgh Sleep Quality Index (PSQI) was used to examine and evaluate the sleep status of the subjects in the past month, and valuable basic information about the participants was collected. PSQI scores were obtained according to specific calculation rules, and the corresponding sleep grouping and subsequent analysis were carried out. Through liquid chromatography-mass spectrometry (LC-MS) non-targeted metabolomics analysis, differences in metabolism were found by bioinformatics analysis in different environments.ResultsBetween the deep-underground and ground (DUvsG) group, 316 differential metabolites were identified and 125 differential metabolites were identified in the good sleep quality vs. poor sleep quality (GSQvsPSQ) group. The metabolic pathways of Phenylalanine, tyrosine and tryptophan biosynthesis (p = 0.0102) and D-Glutamine and D-glutamate metabolism (p = 0.0241) were significantly enriched in DUvsG. For GSQvsPSQ group, Butanoate metabolism was statistically significant (p = 0.0276). L-Phenylalanine, L-Tyrosine and L-Glutamine were highly expressed in the deep-underground group. Acetoacetic acid was poorly expressed, and 2-hydroxyglutaric acid was highly expressed in good sleep quality.ConclusionsThe influence of the underground environment on the human body is more likely to induce specific amino acid metabolism processes, and regulate the sleep-wake state by promoting the production of excitatory neurotransmitters. The difference in sleep quality may be related to the enhancement of glycolytic metabolism, the increase in excitatory neurotransmitters and the activation of proinflammation. L-phenylalanine, L-tyrosine and L-glutamine, Acetoacetic acid and 2-hydroxyglutaric acid may be potential biomarkers correspondingly.
Interventions for social and community participation for adults with intellectual disability, psychosocial disability or on the autism spectrum: An umbrella systematic review
Authors: Giummarra Melita J. , Randjelovic Ivana , O’Brien Lisa 
Published: August 2022

ObjectiveThis umbrella systematic review examined the effectiveness, facilitators, and barriers of interventions for social, community and civic participation for adults on the autism spectrum, or with intellectual or psychosocial disability.Data SourcesEight databases were searched to identify eligible reviews defined by the: Sample (≥50% adults on the autism spectrum or with intellectual or psychosocial disability), Phenomena of Interest (interventions in community settings that aimed to improve social, community or civic participation, or capacity to participate), Design (any), Evaluation (any method that evaluated impacts on participation or capacity to participate), and Research type (reviews as journal articles, dissertations or in grey literature, in English, published 2010-2020).Review MethodsRapid review methods were used. One researcher screened 27,890 records and 788 potentially eligible full texts. A second reviewer independently screened 20% of records, and ambiguous full text publications. Study quality was extracted, and review quality was assessed with the Assessing Methodological Quality of Systematic Reviews (AMSTAR) checklist. Data from 522 studies in 57 eligible systematic reviews were extracted for narrative synthesis. The Corrected Covered Area (CCA) was calculated to indicate overlap between reviews.ResultsThere was a pooled sample of 28,154 study participants, predominantly from studies in North America, the UK and Europe. There was very low overlap between reviews (CCA = 0.3%). Reviews were predominantly low quality: 77.2% of reviews met &lt;50% of AMSTAR criteria. Most studies were low (45.4%) or moderate (38.3%) quality. Three broad intervention categories improved participation, inclusion and belonging outcomes: (1) interventions to help people identify and connect with participation opportunities (e.g., person centred planning); (2) participation opportunities or activities (e.g., joining a community group, sports or outdoor activities, or arts-based activities); and (3) supports to build skills and capacity to participate socially and in the community.ConclusionsThe evidence highlighted that improved social and community participation requires purposeful strategies that identify meaningful participation preferences (e.g., where, when, how, and with whom) and provide support to build capacity or enable ongoing participation. Community capacity building, peer support and advocacy may also be needed to make the community more accessible, and to enable people to exercise genuine choice.
Staged surgery for closed Lisfranc injury with dislocation
Authors: He Wenbao , Xia Jiang , Zhou Haichao , Li Zhendong , Zhao Youguang , Yang Yunfeng , Li Bing 
Published: August 2022

ObjectiveTo investigate the clinical efficacy of staged surgery for patients with closed Lisfranc injury and dislocation.MethodsThis study included 48 patients with acute closed Lisfranc injury and dislocation admitted between July 2016 and July 2021. The patients were divided into two groups. 23 patients in group A underwent staged surgeries included emergency reduction within 4–8 h after injury, and open reduction and internal fixation of Lisfranc injury and first tarsometatarsal joint fusion after the swelling had subsided. 25 patients in group B underwent open reduction and internal fixation as an elective procedure after the swelling had subsided. American Orthopedic Foot and Ankle Society (AOFAS) midfoot scores and visual analog scale (VAS) scores were used for assessment at the final follow-up.ResultsA total of 48 patients with closed Lisfranc injury and dislocation were included. The lengths of hospitalization were 11.52 ± 1.61 day and 19.80 ± 2.37 day in groups A and B, respectively. The total lengths of surgery were 67.34 ± 1.71 min and 104.36 ± 8.31 min in groups A and B, respectively. 48 patients completed the final follow-up (follow-up period range: 12–24 months, mean: 18 months). All fractures had healed at 12–18 weeks after surgery (mean: 14.6 weeks). At the 1-year postoperative follow-up, the AOFAS and VAS score was 86.87 ± 4.24 and 1.91 ± 0.78, respectively, during weight-bearing walking in group A patients and 71.72 ± 5.46 and 3.20 ± 1.17 in group B. By the end of the follow-up period, only 2 patients in group B had developed traumatic arthritis and no patients had joint re-dislocation or required secondary surgery.ConclusionStaged surgery for closed Lisfranc injury with dislocation reduced the incidence of perioperative complications and achieved good surgical outcomes while shortening the lengths of surgery and hospitalization.
Typologies of Intimate Partner Violence Against Women in Five Latin-American Countries: A Latent Class Analysis
Authors: Restrepo Alexandra , Montoya Nilton , Zuluaga Laura 
Published: August 2022

Objectives: To estimate typologies of Intimate Partner Violence against women in some Latin-American countries.Methods: Multistage sampling survey included women aged 15 to 49 (n = 63,321). Latent class analysis was estimated, including psychological, physical, and sexual violence and control.Results: The three-class model had a better fit. 1) The high-level IPV class (23%) comprised those suffering high levels of violence. They had higher education and wealth index, lived in urban settings, and their husbands used alcohol more. 2) The middle-level IPV class (45%) suffered high levels of control but low levels of other violence. They justified IPV more than other classes and this group had a high proportion of women without education. 3) Women in the non-IPV class (32%) did not report IPV.Conclusion: Three typologies of IPV were found: high-level, middle-level, and non-IPV. Policies should create screening, early prevention strategies, and programs based on these typologies. The high-level IPV group can benefit from intense legal and mental health interventions, including alcohol reduction and women’s empowerment. The middle-level IPV group could benefit from interventions to reduce violence justification and increase women’s education.
Increased mRNA Levels of ADAM17, IFITM3, and IFNE in Peripheral Blood Cells Are Present in Patients with Obesity and May Predict Severe COVID-19 Evolution
Authors: Pomar Catalina A. , Bonet M. Luisa , Ferre-Beltrán Adrián , Fraile-Ribot Pablo A. , García-Gasalla Mercedes , Riera Melchor , Picó Catalina , Palou Andreu 
Published: August 2022

Gene expression patterns in blood cells from SARS-CoV-2 infected individuals with different clinical phenotypes and body mass index (BMI) could help to identify possible early prognosis factors for COVID-19. We recruited patients with COVID-19 admitted in Hospital Universitari Son Espases (HUSE) between March 2020 and November 2021, and control subjects. Peripheral blood cells (PBCs) and plasma samples were obtained on hospital admission. Gene expression of candidate transcriptomic biomarkers in PBCs were compared based on the patients’ clinical status (mild, severe and critical) and BMI range (normal weight, overweight, and obesity). mRNA levels of ADAM17, IFITM3, IL6, CXCL10, CXCL11, IFNG and TYK2 were increased in PBCs of COVID-19 patients (n = 73) compared with controls (n = 47), independently of sex. Increased expression of IFNE was observed in the male patients only. PBC mRNA levels of ADAM17, IFITM3, CXCL11, and CCR2 were higher in those patients that experienced a more serious evolution during hospitalization. ADAM17, IFITM3, IL6 and IFNE were more highly expressed in PBCs of patients with obesity. Interestingly, the expression pattern of ADAM17, IFITM3 and IFNE in PBCs was related to both the severity of COVID-19 evolution and obesity status, especially in the male patients. In conclusion, gene expression in PBCs can be useful for the prognosis of COVID-19 evolution.
Modeling as an effective management tool for the integrated regional development
Authors: Eduardovich-Tyupakov Konstantin , Alexandrovich-Verkhorubov Sergey , Alexeevna-Beloglazova Lyudmila , Magometovna-Pogorova Zamira , Savarbekovich-Hautiev Zaurbek 
Published: August 2022

Ensuring sustainable territorial development is one of the key tasks for developing regional industries and increasing the level of food security of the regions and the country in general. The solution to the problem of developing and implementing a competitive mechanism for territorial development should be based on the principles and methods of modern strategic territorial-sectoral planning with a focus on the maximum use of the resources of the existing local potential. This study analyzes modeling as an effective management tool for integrated regional development. To that end, approaches based on constructing multivariate regression models are utilized. Based on the results, the main problem of management systems for the integrated territorial development is associated with an incorrect assessment of their starting capabilities, which results in the low performance of the implementation mechanism. A reliable methodological basis here can be an approach to managing territorial development using a system of linked indicators that consider more than just the parameters of social development. The list of priority areas (blocks), which should serve as a fundamental basis for developing concepts for the integrated development of regions, must include natural and climatic, technical and technological, infrastructural, and marketing characteristics.
Keywords: regional development, regional competitive potential, modeling, integrated development .
Hubungan Interaksi Orangtua dan Interaksi Teman Sebaya dengan Perkembangan Moral siswa MAS Babussalam Kabupaten Tapanuli Selatan
Authors: Natogar Surya , Parinduri Abrar , Nuraini Nuraini 
Published: August 2022

This study aims to determine the relationship between parents interaction and student self-regulated learning in MAS Babusslam of South Tapanuli District. This research is a quantitative research with a population of 295 students of MAS Babusslam of South Tapanuli District. By using the total sampling technique obtained a sample of 170 people. Data collection techniques used three scales, consisting of a scale of parents interaction, peer interaction, moral development. Data analysis techniques using Multiple Regression Analysis. The results showed a significant positive correlation with parents interaction with self-regulated learning r_xy = 0.513 with p = 0.000, coefficient r^2= 0.263. This shows that self-regulated learning is shaped by parents interaction with a contribution of 26.3%. There is a significant positive correlation between peer interaction and moral development, where the coefficient of r_xy = 0.521 with p = 0.000, r^2 = 0.271. This shows that self-regulated learning is formed by peer interaction with a contribution of 27.1%. In addition, based on the results of data analysis, there was a significant relationship between parents interaction and peer interaction with self-regulated learning, where the coefficient of r_xy = 0.724 with p = 0.000 means p <0.050. The determinant coefficient (r^2) of the relationship between parents interaction, peer interaction and the dependent variable of self-regulated learning is r^2 = 0.524. This shows that self-regulated learning is formed by parents interaction and peer interaction with a contribution of 52.4%.