bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model
Authors: Seborova Karolina , Koucka Kamila , Spalenkova Alzbeta , Holy Petr , Ehrlichova Marie , Sychra Tomas , Chen Lei , Bendale Hersh , Ojima Iwao , Sandoval-Acuña Cristian , Truksa Jaroslav , Soucek Pavel , Vaclavikova Radka 
Published: November 2022

Taxanes are widely used in the treatment of ovarian carcinomas. One of the main problems with conventional taxanes is the risk of development of multidrug resistance. New-generation synthetic experimental taxoids (Stony Brook Taxanes; SB-T) have shown promising effects against various resistant tumor models. The aim of our study was to compare the in vitro efficacy, intracellular content, and in vivo antitumor effect of clinically used paclitaxel (PTX) and SB-Ts from the previously tested second (SB-T-1214, SB-T-1216) and the newly synthesized third (SB-T-121402, SB-T-121605, and SB-T-121606) generation in PTX resistant ovarian carcinoma cells NCI/ADR-RES. The efficacy of the new SB-Ts was up to 50-times higher compared to PTX in NCI/ADR-RES cells in vitro. SB-T-121605 and SB-T-121606 induced cell cycle arrest in the G2/M phase much more effectively and their intracellular content was 10–15-times higher, when compared to PTX. Incorporation of SB-T-121605 and SB-T-121606 into therapeutic regimens containing PTX were effective in suppressing tumor growth in vivo in NCI/ADR-RES based mice xenografts at small doses (≤3 mg/kg), where their adverse effects were eliminated. In conclusion, new SB-T-121605 and SB-T-121606 analogs are promising candidates for the next phase of preclinical testing of their combination therapy with conventional taxanes in resistant ovarian carcinomas.
Innovative feedstocks for optimal mass production of the edible long-horned grasshopper, Ruspolia differens
Authors: Margaret Kababu , Collins Mweresa K. , Subramanian Sevgan , Egonyu James P. , Nakimbugwe Dorothy , Ssepuuya Geoffrey , Faith Nyamu , Ekesi Sunday , Tanga Chrysantus M. 
Published: November 2022

The edible long-horned grasshopper Ruspolia differens Serville (Orthoptera:Tettigoniidae) is a highly nutritious food source consumed in over 20 African countries. Its occurrence is highly seasonal, and wild harvesting is carried out using locally designed and inefficient light traps, thus limiting sustainable utilization as an important food source. To ensure year-round production and availability of R. differens, we evaluated the effects of low-cost and affordable diets based on agricultural by-products on their growth performance, survival, fecundity, and longevity. A total of four diets with varying ratios of agricultural by-products were evaluated: Diet 1 [33.3% maize bran (MB) + 33.3% wheat bran (WB) + 33.3% Moringa oleifera leaf powder (MOLP)], Diet 2 [25% MB + 25% WB + 25% MOLP + 25% shrimp powder (SP)], Diet 3 [20% MB + 20% WB + 20% MOLP + 20% SP + 20% soya bean meal], and Diet 4 (“control”—routinely used diet). The grasshoppers were subjected to the diets from the 1st nymphal instar (24-h-old stages) through adult stages until death. Diet 3 had the highest crude protein content (28%) and digestibility (74.7%). R. differens fed Diet 3 had the shortest development time (57 days) [p &lt; 0.001], highest survival (87%) [p &lt; 0.001], and maximum longevity (89 days) [p = 0.015] and fecundity (247 eggs/female) [p = 0.549] across the various diets. Female survival rate (59%) on Diet 3 was significantly higher compared to the males (41%). The adult female weight gain was significantly higher compared to males fed on different diets. Percentage hatchability of eggs was not significantly different when females were fed Diet 3 and Diet 2. There was a significantly positive correlation between longevity and fecundity of R. differens reared on Diet 2 and 3. These diets could be further optimized and fine-tuned for improved cost-effective mass production of R. differens continent-wide to reduce dependence on erratic and poor seasonal harvest during swarms.
Effect of online aerobic exercise training in patients with bipolar depression: Protocol of a randomized clinical trial
Authors: Wang Xueqian , Luo Huirong , Zhang Yinlin , Mao Maolin , Lu Yulin , Zhang Zheng , Jiang Chunfeng , Luo Qinghua 
Published: November 2022

IntroductionBipolar disorder (BD) is a common and debilitating mental illness that affects about 400 million people worldwide, decreasing their functionality and quality of life. Medication and psychotherapy are recommended for treatment of BD, while some evidence indicates that exercise could improve the clinical outcome of BD. This study aims to investigate whether exercise intervention could reduce the mood symptoms and inflammation level of BD.MethodsThis is a longitudinal, interventional, randomized, and single-blind trial. We plan to recruit 94 patients diagnosed with BD in depression episode. Patients will be randomly assigned to treatment as usual + aerobic exercise group (intervention group) and treatment as usual (TAU) only group, at a ratio of 1:1. The intervention group will undergo 40-min aerobic exercise training twice a week for eight weeks. The primary outcome of this study is the mean change of Hamilton Depression Rating Scale 17 (HAMD 17) scores from baseline to week 8. The Young Manic Rating Scale (YMRS), Self-Rating Depression Scale (SDS), and Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) levels will also be measured. The measurements will be performed at baseline, immediately after intervention and two months after intervention.DiscussionAerobic exercise training + treatment is expected to bring more benefits to BD patients than TAU only. This trial might provide stronger evidence of physical exercise efficacy for BD treatment.Clinical trial registrationThis study was approved by the Chinese Clinical Trial Registry (Registration Code: ChiCTR2200057159). Registered on 1 March 2022.
A 6-day high-intensity interval microcycle improves indicators of endurance performance in elite cross-country skiers
Authors: Rønnestad Bent R. , Bjerkrheim Kjetil Andre , Hansen Joar , Mølmen Knut Sindre 
Published: November 2022

PurposeThe aim of this study was to compare the effects of a 6-day high-intensity interval (HIT) block [BLOCK, n = 12, maximal oxygen uptake (V̇O2max = 69. 6 ± 4.3 mL·min−1·kg−1)] with a time-matched period with usual training (CON, n = 12, V̇O2max = 69.2 ± 4.2 mL·min−1·kg−1) in well-trained cross-country (XC) skiers on physiological determinants and indicators of endurance performance. Furthermore, the study aimed to investigate the acute physiological responses, including time ≥90% of V̇O2max, and its associated reliability during repeated HIT sessions in the HIT microcycle.MethodsBefore the 6-day HIT block and following 5 days of recovery after the HIT block, both groups were tested on indicators of endurance performance. To quantify time ≥90% of V̇O2max during interval sessions in the HIT block, V̇O2 measurements were performed on the 1st, 2nd, and last HIT session in BLOCK.ResultsBLOCK had a larger improvement than CON in maximal 1-min velocity achieved during the V̇O2max test (3.1 ± 3.1% vs. 1.2 ± 1.6%, respectively; p = 0.010) and velocity corresponding to 4 mmol·L−1 blood lactate (3.2 ± 2.9% vs. 0.6 ± 2.1%, respectively; p = 0.024). During submaximal exercise, BLOCK displayed a larger reduction in respiratory exchange ratio, blood lactate concentration, heart rate, and rate of perceived exertion (p &lt; 0.05) and a tendency towards less energy expenditure compared to CON (p = 0.073). The ICC of time ≥90% V̇O2max in the present study was 0.57, which indicates moderate reliability.ConclusionsIn well-trained XC skiers, BLOCK induced superior changes in indicators of endurance performance compared with CON, while time ≥90% of V̇O2max during the HIT sessions in the 6-day block had a moderate reliability.
Penambahan Tepung Bayam Merah (Amaranthus tricolor L.) Pada Pakan Untuk Meningkatkan Kualitas Warna Ikan Koi (Cyprinus carpio L)
Authors: Putra Muhammad Aidil Desta , Lumbessy Salnida Yuniarti , Setyowati Dewi Nur’aeni 
Published: November 2022

Karotenoid adalah suatu pigmen alami yang dapat ditemukan pada hewan, tanaman dan mikroorganisme, tetapi tidak dapat disintesis oleh sebagian besar hewan termasuk ikan, sehingga harus ditambahkan pada pakan. Salah satu tumbuhan yang potensial sebagai sumber zat warna alami adalah bayam merah (Amaranthus tricolor L). Tujuan dari penelitian ini adalah untuk menganalisa pengaruh penambahan tepung bayam merah pada pakan untuk meningkatkan kualitas warna ikan koi (Cyprinus carpio L). Metode yang digunakan adalah eksperimental dengan menggunakan pola Rancangan Acak Lengkap (RAL) yang terdiri atas 4 perlakuan dan 3 kali ulangan sehingga diperoleh total 12 unit percobaan. Perlakuan yang diuji adalah penambahan konsentrasi tepung bayam merah yang berbeda dalam pakan ikan koi, yang terdiri atas : P0: tepung bayam merah 0% (kontrol), P1: tepung bayam merah 3%, P2: tepung bayam merah 6%, P3: tepung bayam merah 9%. Hasil penelitian ini menunjukkan bahwa penambahan tepung bayam merah (A. tricolor L) pada pakan memberikan pengaruh yang nyata terhadap kandungan karotenoid ikan, peningkatan kualitas warna (uji hunterlab dan uji potoshop), pertumbuhan berat mutlak dan laju pertumbuhan spesifik, tetapi tidak mempengaruhi nilai pertumbuhan panjang mutlak, rasio konversi pakan (FCR) dan tingkat kelangsungan hidup (SR). Penambahan tepung bayam merah (A. tricolor L) dengan konsentrasi 9% dapat memberikan kandungan karotenoid sebanyak 54,64 µmol/g, uji hunterlab (L*: 69,84, a*: 20,95 dan b*:37,7), uji potoshop 11,63%, pertumbuhan berat mutlak 2,21 g dan laju pertumbuhan spesifik 0,84 %/hari.
Sources of financial support for inclusive development of territorial communities in the state of war
Authors: Zheliuk Tetiana , Zhukovska Alina 
Published: November 2022

Introduction. The vitality of territorial communities in the conditions of modern challenges requires the implementation of a regional policy of using an inclusive approach which provides for the creation of safe conditions for the integral development of territories, an effective system of civil protection according to the type of territory: territories with special conditions for development; the territory of sustainable development; poles of economic growth. The realism of this task depends on organizational and institutional support and accumulation of internal and external financial resources, activation of project grant funding. Purpose of the research. Justification of approaches to financial provision of integral, safe development of territorial communities by substantiating the sources of financial provision of the system of civil protection of territories and thereby ensuring their balanced and inclusive development.Research methods. System approach – to justify the place of the inclusive approach in the implementation of the new regional policy in the conditions of martial law. Structural analysis - for the purpose of researching the structure of internal and external financial resources for the creation of modern systems of civil protection of communities. Comparative analysis - with the aim of identifying modern possibilities of external grant funding for the implementation of projects of civil protection of territories.Results. The scientific and organizational approaches to the accumulation and use of financial resources for the creation of an effective system of civil protection of the population of territorial communities, as a necessary component of the inclusive-oriented vector of the implementation of regional policy in the conditions of martial law, are substantiated.Perspectives. The author’s work can be used in the budgeting of the development of territorial communities and the search for additional sources for the financial support of the creation of a modern system of civil protection of territories under martial law.
COMPARATIVE ANALYSIS OF THE ENDURANCE OF UV-CURED ADHESIVE JOINTS
Authors: Ogrodniczek Jacek 
Published: November 2022

The aim of the study was to compare the strength of adhesive joints bonded with two different UV-cured adhesives in different exposure times. The adhesives used in the research differed in viscosity. The first adhesive Multibond 5550 was characterised by low viscosity, the second adhesive Multibond 5544 was characterised by high viscosity. The adhesive joints were made from a 316L steel sample and a sample made from polymethyl methacrylate. The adhesive joints were cured at three time intervals: 5 minutes, 10 minutes and 20 minutes. The strength of the adhesive bonds was compared using the MANOVA test. Statistical analysis showed that there was a statistical difference between the adhesives cured for 10 minutes. It was also found that joints where a high viscosity adhesive was used showed similar strength results for 10 and 20 minutes of adhesive exposure to UV rays. Statistical analysis was performed using RStudio software and the R programming language.
The Effectiveness Of Moringa Leaf Extract (Moringa oleifera) on Cadmium and LDL Cholesterol Levels in Blood as Indicators of Atherosclerosis in Cadmium (Cd) Induced White Rats (Rattus norvegicus)
Authors: Nabilla Vernanda Arsya , Lestari Indah , Rahayuningsih Christ Kartika , Christyaningsih Juliana 
Published: November 2022

Moringa leaves (Moringa oleifera) have chelating agent properties that act as natural antioxidants in binding heavy metals and free radical scavengers, with cadmium being one of the heavy metals free radicals having toxic effects on the body. Exposure to cadmium can reduce the activity of lipoprotein lipase enzymes (LPL) which function in the triglycerides and free fatty acids catabolism process, and can increase cholesterol and triglyceride levels in the blood. This study aims to determine the effectiveness of Moringa (Moringa oleifera) on Cadmium chloride-induced white rats (Rattus norvegicus) using an experimental research design with a quantitative analysis technique. This study uses the level of cadmium and LDL cholesterol for the dependent variable and the dose of Moringa leaf extract (Moringa oleifera) for its independent variable. The samples used are white rats (Rattus norvegicus) aged 8-12 weeks with a weight of 150-200 grams, along with blood drawn from the heart for the specimen. The researcher conducted the study at the Faculty of Veterinary Medicine, Airlangga University; Surabaya Health Laboratory Center; and Surabaya Bakti Analysis Laboratory from October 2021 to June 2022 using Atomic Absorption Spectrophotometry (AAS) and Chemical Analyzer BS-200. The results show that the average value of cadmium and LDL cholesterol levels in white rats in treatment group 1 are 0.605 g/dL and 8.25 mg/dL, group 2 are 0.075 g/dL & 18.5 mg/dL; and group 3 are 0.08125 g/dL and 12 mg/dL. Based on the statistical analysis of the One-Way ANOVA test, the sig. p-value is > 0.05. Thus, the average value of cadmium and LDL cholesterol has no significant difference. Compared to the 400 mg/kgBW and 500 mg/kgBW, the 600 mg/kgBW dose has the best effectiveness in reducing LDL cholesterol in white rats (Rattus norvegicus) after being induced with cadmium chloride. This study recommends consuming fresh Moringa leaves (Moringa oleifera) as much as 66.522 grams per human/day as an additional antioxidant and chelating agent.
Pulse Oximeter Design for SpO2 and BPM Recording on External Memory to Support the Covid-19 Diagnosis
Authors: Syaifudin Syaifudin , Triwiyanto Triwiyanto , Harditamara Dinar Awalin , Masood Faraz 
Published: November 2022

COVID-19 (coronavirus disease) is an acute respiratory illness induced by exposure to coronavirus 2 in 2019 (SARS-CoV-2). WHO confirms that there were 1.8 million registered deaths in 2020 and that there were 3.5 million recorded deaths in 2021. People who are infected with SARS-CoV-2 without symptoms should have a pulse oximeter. Early detection of low oxygen levels in the blood can lead to fewer complications. Continuously decreasing oxygen saturation, if not controlled, will cause hypoxia (an abnormal respiratory circulation system condition that causes breathlessness). In normal conditions, oxygen levels and heart rate are related. When a person has a shortage of oxygen (breathlessness), their heart rate increases to supply the oxygen. Regulating heart rate can aid in the prevention of disorders such as arrhythmia, coronary heart disease, and hypertension. A pulse oximeter is used to measure the oxygen saturation in the blood and the patient's heart rate (BPM) with non-invasive methods. Conventional pulse oximeters do not support users by not having features such as medical records, which are required for further examination by a doctor. The purpose of this research is to make a pulse oximeter with external storage capability. The difference in wavelength between the red and infrared LED lights that will be captured by the photodiode is measured. SpO2 and HR values will be generated as a result of comparative measurements. Using a MAX30102 sensor to detect SpO2 and heart rate, and an Arduino Mega256 to process data for display on the TFT Nextion with Memory Card storage. By comparing the module to a conventional pulse oximeter, data was collected 10 times for each respondent. The maximum SpO2 error value is 0.43%, whereas the BPM parameter has the largest error value of 2.02% and the smallest error value of 0.01% based on the data collected. A significant error value is caused by finger movement. The module is usable, based on the results, because the maximum error tolerance for a pulse oximeter is 1% SpO2 and 5% BPM, according to the 2001 Ministry of Health Ministry's Guidelines for Testing and Calibrating Medical Devices.
Pengaruh Penambahan Bubuk Daun Salam (Syzygium polyanthum) terhadap Kadar Protein dan Total Padatan Keju Rendah Lemak
Authors: Wasliyah Ukhtun , Setyawardani Triana , Sumarmono Juni 
Published: November 2022

Tujuan penelitian ini adalah untuk mempelajari pengaruh penambahan daun salam sebagai sumber fitokimia terhadap kadar protein dan total padatan keju rendah lemak. Materi penelitian yang digunakan antara lain lain susu low fat komersial, bubuk daun salam, kalsium klorida, susu skim bubuk, rennet, bakteri mesofilik sebagai starter, dan garam dapur. Penelitian dilakukan secara eksperimen dengan menggunakan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan dan 4 kali ulangan. Perlakuan meliputi penambahan daun salam bubuk 0%; 0,25%; 0,5%; 0,75% dan 1%. Keju diperam selama satu minggu kemudian dianalisis protein dan total padatannya. Data dianalisis menggunakan analisis variansi. Hasil menunjukkan penambahan bubuk daun salam berpengaruh tidak nyata terhadap protein dan total padatan. Rataan kandungan protein diperoleh sebesar 29,53±4,63% dan total padatan sebesar 42,21±2,26%. Penambahan daun salam dan bentuk bubuk hingga satu persen tidak menyebabkan perubahan pada kadar protein dan total padatan keju rendah lemak.
Kata kunci : Keju, susu low fat, daun salam, kandungan protein, total padatan.
Analisis Usaha Ayam Ras Petelur dengan Sistem Kandang Berbeda di PT. As Putra Group Kuningan
Authors: Indah Laela Rahmah Ulfa , Triasih Triasih , Imanudin Oki 
Published: November 2022

Penelitian ini dilaksanakan di PT. AS Putra Group Kuningan, mulai tanggal 8 Maret sampai dengan 10 April 2021. Penelitian ini bertujuan untuk mengetahui analisis usaha ayam ras petelur dengan sistem kandang berbeda yaitu kandang sistem open house dan sistem close house. Metode penelitian yang digunakan adalah survei dibantu dengan kuesioner. Berdasarkan hasil penelitian di PT. AS Putra Group Kuningan selama satu periode produksi (14 bulan) pendapatan usaha sistem close house Rp 8.251.431.862 dengan skala usaha 92.000 ekor daripada sistem open house Rp 4.139.136.605,15 dengan skala usaha 57.000 ekor atau keuntungan per ekor pada kandang close house sebesar Rp 89.689 > Rp 72.616 pada kandang open house. Berdasarkan hasil perhitungan dari dua sistem pemeliharaan didapat nilai R/C rasio kandang close house sebesar 1,30 > 1,23 pada kandang open house, B/C rasio kandang close house sebesar 0,30 > 0,23 pada kandang open house, BEP produksi pada kandang close house sebesar 1.294.538,7 kg dan 847.897,5 kg pada kandang open house, BEP harga pada kandang open house sebesar Rp 17.622,2 > Rp 17.552,6 pada kandang close house dan PP kandang open house sebesar 2,2 periode yaitu 30,8 bulan < 2,65 periode atau 37,1bulan pada kandang close house. Meskipun kandang close house lebih lama 6,3 bulan PP nya namun karena umur ekonomisnya lebih lama (20 tahun) dibandingkan open house (10 tahun) maka kandang close house lebih menguntungkan. Dari hasil analisis maka dapat disimpulkan bahwa usaha ayam ras petelur di PT. AS Putra Group Kuningan lebih menguntungkan dengan sistem close house.
DAMPAK PANDEMI COVID-19 TERHADAP PERMASALAHAN EKONOMI SYARIAH DI INDONESIA
Authors: Malita Sari Indri , Wigati Sri 
Published: November 2022

The outbreak of a pandemic disease that entered Indonesia in 2020 had forced all activities to be limited, this resulted in the government having to make rules that encourage the Indonesian people to limit mobility activities so that the spread of Covid-19 can be suppressed. Of course, this has an impact on the Indonesian economy, including the sharia economy. In this regard, this study aims to determine the impact of the Covid-19 pandemic on sharia economic problems that previously existed before the pandemic. These various Islamic economic problems in Indonesia have made Islamic financial institutions undeveloped, there are several factors experienced by the Government in dealing with existing obstacles. This study uses a qualitative type with a descriptive approach method. In this study, the focus is on sharia economic problems when the Covid-19 pandemic first entered Indonesia.
Keywords: Sharia Economics Problems, Covid-19, Pandemic.