bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploitation of Document Management Systems in Construction Industry
Authors: Mandicak T , Mesaros P , Spisakova M , Kanalikova A 
Published: October 2022

Abstract
Document management systems are among the information systems that have several benefits. The main benefits include a reduction of time and of transmitting documents. These systems also allow better access to documents for all participants in construction projects. The use of Document Management Systems in the world is growing in every industry. There has been a dramatic increase in the last few years. However, some construction companies are conservative and are adopting new trends and innovations more slowly. This research addresses this issue of the use of information systems in Slovakia. The research involved investors, contractors, sub-contractors, designers operating in Slovakia. The research sample consisted of 55 respondents, including large construction companies.
Stability of travertine barrier on Milino Lake
Authors: Štimac Grandić I , Drobac J , Bede N , Ružić I 
Published: October 2022

Abstract
In March 2018, part of the travertine barrier at Milino Lake, in Plitvice Lakes National Park in Croatia, broke off, significantly altering the flow of water over the barrier. Encouraged by this event, the Faculty of Civil Engineering in Rijeka conducted a monitoring and analysis of the erosion dynamics of the travertine barriers on Plitvice Lakes. Within the project, the analyses of the stability of the travertine barriers were carried out. To the author's knowledge, physical and mechanical properties of travertine have been determined for the first time on samples excluded from travertine barriers between cascading lakes. In addition, no one has previously checked the stability of the travertine barrier located between the two lakes. The maximum compressive and tensile stresses calculated on a numerical model of the broken part of the barrier are compared with the compressive and tensile strength determined by laboratory tests on travertine samples taken from the broken barrier. By comparing the calculated stresses and determined travertine strength, it was found that the stability of the analysed part of the broken travertine barrier at Milino Lake was compromised even if only the self-weight of the collapsed part of the barrier is taken into account.
Method of optimizing deterministic small free-form surfaces for off-axis optical systems with extremely low aberration
Authors: Zhang Xu , Yu Jie , Wang Liping , Jin Chunshui 
Published: October 2022

Abstract
A mapping model of arbitrarily shaped surfaces and the system image quality is constructed to examine the optimization of the residual aberration of an off-axis optical system to construct an off-axis optical system with very small aberrations. First, orthogonal surfaces are chosen within the arbitrary aperture. The mapping relationship between the orthogonal surfaces and system wavefront aberration is then established. Finally, the surfaces required for optimization are acquired by solving the mapping relationship through singular value decomposition and the Gauss–Newton algorithm. The residual aberration of the system is optimized using free-form surfaces with small deviations. In this paper, the residual aberration of an off-axis optical system with a non-circular aperture is optimized by adopting the above method, with the residual aberration of the system reducing from 0.549 nm (root-mean-square, RMS) to 0.443 nm (RMS) after adding a small free-form surface to a single lens, and to 0.393 nm (RMS) after adding small free-form surfaces to two lenses. The optical system with a circular aperture is optimized and the residual aberration of the system is reduced from 2 nm (RMS) to 0.47 nm (RMS).
Alfvén continuum in the presence of a magnetic island in a cylinder configuration
Authors: YANG Junhui , CAO Jinjia , ZHAO Jianhua , DAI Yongzhi , XIANG Dong 
Published: October 2022

Abstract
In this work, the effect of a magnetic island on Alfvén waves is studied. A physical model is established wherein Alfvén waves propagate in the presence of a magnetic island in a cylindrical geometry. The structure of the Alfvén wave continuum is calculated by considering only the coupling caused by the periodicity in the helical angle of the magnetic island. The results show that the magnetic island can induce an upshift in the Alfvén continuum. Moreover, the coupling between different branches of the continuous spectrum becomes more significant with increasing continuum mode numbers near the boundary of the magnetic island.
Identification of a ferroptosis-related long non-coding RNA signature for prognosis prediction of ovarian cancer
Authors: Gao Jian , Pang Xiaoao , Ren Fang , Zhu Liancheng 
Published: October 2022

Abstract
Ovarian cancer is one of the deadliest malignant tumors. Ferroptosis is closely related to various cancers, including ovarian cancer, but the genes involved in regulating ferroptosis in ovarian cancer are still unclear. The aim of this study is to construct a long non-coding RNA (lncRNA) signature related to ferroptosis and evaluate its relationship with the prognosis and clinicopathological characteristics of patients with ovarian cancer. In this study, a prognostic risk model comprising 18 lncRNAs related to ferroptosis was obtained. Compared to the low-risk group, the high-risk group based on the FerRLSig score had significantly poorer overall survival (P &lt; 0.001). The receiver operating characteristics curve supported the accuracy of the model, established a prognostic nomogram combining FerRLSig and clinical characteristics, and showed a good prognosis and survival risk stratification predictive power. In addition, Gene Set Enrichment Analysis (GSEA) showed that FerRLSig was involved in many malignant tumor-related immunomodulatory pathways. Based on the risk model, we found that immune status and immunotherapy, chemotherapy, and targeted therapy were significantly different between the high-risk and low-risk groups. This study provided a more in-depth understanding of the molecular and signaling pathways of ferroptosis in ovarian cancer and showed the impact of tumor microenvironment on ovarian cancer, as well as provided a prognostic model for ovarian cancer patients to guide the clinical treatment of ovarian cancer.
Cortical and subcortical grey matter correlates of psychopathic traits in a Japanese community sample of young adults: sex and configurations of factors’ level matter!
Authors: Chester Sally C , Ogawa Tatsuyoshi , Terao Maki , Nakai Ryusuke , Abe Nobuhito , De Brito Stephane A 
Published: October 2022

Abstract
While neuroimaging research has examined the structural brain correlates of psychopathy predominantly in clinical/forensic male samples from western countries, much less is known about those correlates in non-western community samples. Here, structural magnetic resonance imaging data were analyzed using voxel- and surface-based morphometry to investigate the neuroanatomical correlates of psychopathic traits in a mixed-sex sample of 97 well-functioning Japanese adults (45 males, 21–39 years; M = 27, SD = 5.3). Psychopathic traits were assessed using the Self-Report Psychopathy Scale (SRP-SF; 4th Edition). Multiple regression analysis showed greater Factor 1 scores were associated with higher gyrification in the lingual gyrus, and gray matter volume in the anterior cingulate cortex and amygdala/hippocampus border. Total psychopathy and Factor 1 scores interacted with sex to, respectively, predict cortical thickness in the precuneus and gyrification in the superior temporal gyrus. Finally, Factor 1 and Factor 2 traits interacted to predict gyrification in the posterior cingulate cortex. These preliminary data suggest that, while there may be commonalities in the loci of structural brain correlates of psychopathic traits in clinical/forensic and community samples, the nature of that association might be different (i.e. positive) and may vary according to sex and configurations of factors’ level.
A Systematic Review on the Interest of Drug-tolerant Assay in the Monitoring of Inflammatory Bowel Disease
Authors: Barrau Mathilde , Duprat Manon , Veyrard Pauline , Tournier Quentin , Williet Nicolas , Marc Phelip Jean , Waeckel Louis , Cheifetz Adam S , Papamichael Konstantinos , Roblin Xavier , Paul Stephane 
Published: October 2022

AbstractMany patients with inflammatory bowel disease [IBD] are treated with anti-tumour necrosis factor [TNF] therapies, of which infliximab [IFX] is most commonly used. Loss of response [LOR] to anti-TNF therapy due to immunogenic failure accounts for 20% of subsequent medical intervention and is defined, using a drug-sensitive assay, as low or undetectable concentration of drug with high titres of anti-drug antibodies [ADAb]. We performed a systematic review to investigate the use of a drug-tolerant assay during both induction and maintenance, to monitor patients treated with anti-TNFs. After the search on PubMed, 90 publications were reviewed. Most ADAb detection methods are drug-sensitive, cannot detect ADAb in the presence of drug, and therefore cannot be used close to drug administration when the drug concentration is too high. To overcome this major limitation, several drug-tolerant techniques have been developed and will be discussed in this review. Using drug-tolerant assays, ADAb against IFX or adalimumab [ADM] can be detected during induction and predict primary non-response or LOR. Drug-sensitive assays do not allow detection of ADAb during the induction phase when IFX or ADM concentration is typically high.
Diagnostics and management of headache in general practice
Authors: Carlsen Louise Ninett , Stefansen Simon , Ahnfeldt-Mollerup Peder , Højland Jensen Rigmor , Saxhaug Kristoffersen Espen , Møller Hansen Jakob , Lykkegaard Jesper 
Published: October 2022

Abstract

Background
Headache disorders are globally prevalent and insufficient treatment contribute to low quality of life, increased disability, and socioeconomic costs. However, headache can to a large extent be treated appropriately by general practitioners.

Objective
To explore general practitioners’ (GPs’) management of patients with headache lasting ≥6 months.

Methods
In this retrospective descriptive cross-sectional study based on medical audit, all GPs practicing in Vejle municipality (population 116,992), Denmark, were invited to review their latest 20 patients with headache. Outcome measures were headache diagnostics, treatment, and referrals. Factors associated with referral to neurological treatment were examined by logistic regression.

Results
Of 26 invited practices, 19 participated reporting on 367 patients with lasting headache (71.4% women; mean-age 48.5 years). One hundred and sixty-one patients had migraine (44%; IQR: 28–60%), 140 (38%; IQR: 25–44%) had tension-type headache; 243 (66%; IQR: 50–79%) used simple analgesics, 147 (40%; IQR: 29–59%) triptans, 37 (10%; IQR: 0–14%) opioids, 93 (25%; IQR: 20–35%) were prescribed preventive medication; 176 (48%; IQR: 48–59%) were referred to neurologist, and 92 (25%; IQR: 10–37%) were referred to CT or MRI scan. Associated factors for referral were &gt;1 headache diagnosis (aOR 1.75 [95% CI: 1.05–2.95]; P = 0.03), post-traumatic headache (aOR 2.53 [95% CI: 1.25–5.38]; P = 0.01), unspecific headache (aOR 2.04 [95% CI: 1.08–3.93]; P = 0.03), and using preventive treatment (aOR 2.75 [95% CI: 1.68–4.57]; P &lt; 0.001).

Conclusion
This study provides insights to how GPs manage patients with long-lasting headache. Focus should be on reducing opioids, increasing preventive treatment, and keeping more patients in primary care.
Genome Assembly of the Medicinal Plant Voacanga thouarsii
Authors: Cuello Clément , Stander Emily Amor , Jansen Hans J , Dugé de Bernonville Thomas , Lanoue Arnaud , Giglioli-Guivarc'h Nathalie , Papon Nicolas , Dirks Ron P , Jensen Michael Krogh , O'Connor Sarah Ellen , Besseau Sébastien , Courdavault Vincent 
Published: October 2022

Abstract
The Apocynaceae tree Voacanga thouarsii, native to southern Africa and Madagascar, produces monoterpene indole alkaloids (MIA), which are specialized metabolites with a wide range of bioactive properties. Voacanga species mainly accumulates tabersonine in seeds making these species valuable medicinal plants currently used for industrial MIA production. Despite their importance, the MIA biosynthesis in Voacanga species remains poorly studied. Here, we report the first genome assembly and annotation of a Voacanga species. The combined assembly of Oxford Nanopore Technologies long-reads and Illumina short-reads resulted in 3,406 scaffolds with a total length of 1,354.26 Mb and an N50 of 3.04 Mb. A total of 33,300 protein-coding genes were predicted and functionally annotated. These genes were then used to establish gene families and to investigate gene family expansion and contraction across the phylogenetic tree. A transposable element (TE) analysis showed the highest proportion of TE in Voacanga thouarsii compared with all other MIA-producing plants. In a nutshell, this first reference genome of V. thouarsii will thus contribute to strengthen future comparative and evolutionary studies in MIA-producing plants leading to a better understanding of MIA pathway evolution. This will also allow the potential identification of new MIA biosynthetic genes for metabolic engineering purposes.
Determinants of self-reported adherence to COVID-19 regulations in Spain: social norms, trust and risk perception
Authors: Cabrera-Álvarez Pablo , Hornsey Matthew J , Lobera Josep 
Published: October 2022

SummaryFailure of individuals to voluntarily observe regulations and recommendations around mitigating COVID-19 (e.g. social distancing; frequent handwashing) is often cited as a reason why some countries struggled to curtail the spread of the virus. Understanding the factors that are associated with people’s willingness to comply with COVID-19 regulations and recommendations is an important step in helping policy makers and health officials reduce the impact of this (and future) pandemics. In the current study we examined this question in one of the countries hardest hit by the pandemic: Spain. A large, representative survey (N = 2100) revealed that several factors were positively associated with willingness to comply to COVID-19 regulations and recommendations. In decreasing order of predictive value, these were: (i) perceptions of whether friends and family were complying (i.e. norms), (ii) trust in science as a basis for lawmaking, (iii) perceived effectiveness of regulations and (iv) perception of risk of infection. These results point to the importance of influencing social norms as the primary way to improve adherence to the health regulations of COVID-19; more important than intrapsychic considerations such as efficacy and risk.
Exploring the beliefs and experiences with regard to COVID-19 vaccine hesitancy and acceptance in a slum of Karachi, Pakistan
Authors: Qasim Rubina , Shah Hakim , Sultan Aqsa , Yaqoob Muhammad , Haroon Rukhsana , Mistry Sabuj Kanti , Bestman Amy , Yousafzai Mohammad Tahir , Yadav Uday Narayan 
Published: October 2022

SummaryThe COVID-19-related misinformation and vaccine hesitancy is a widespread global concern and a recognized public health problem in Pakistan. The current research sought to explore the beliefs and experiences with regard to COVID-19, including vaccine hesitancy and acceptance, in a slum of Karachi, Pakistan. This study used an interpretivist epistemological approach for data collection and employed in-depth interviews (IDIs) and focus group discussions (FGDs) to explore the themes of interest. IDIs and FDGs were conducted in the local language (Pashtu) and Urdu, using semi-structured interview guides. A hybrid thematic analysis approach (use of both inductive and deductive coding) was used to analyze the data. We identified two key themes: the first related to vaccine hesitancy and refusal and included the role of personal belief systems, vaccine mistrust and public perceptions in hesitancy; the second related to vaccine acceptance and included knowledge and awareness about the vaccine and trusted sources of information. Religious beliefs and cultural norms influenced attitudes toward COVID-19 and vaccination. This study also found that awareness about the COVID-19 vaccine in this sample was influenced by sex, educational status and socioeconomic status. Participants with good health literacy and those from healthcare backgrounds were more likely to share views that indicated vaccine acceptance. The findings of this study are being used to co-design a comprehensive intervention to dispel COVID-19 misinformation and vaccine hesitancy across a range of stakeholders such as youths, community leaders, family members, faith leaders, schools and community-based local organizations in Pakistan.
Spatial and temporal evolution of total factor productivity of low-carbon tourism industry based on DEA–Malmquist Index model
Authors: Tang Zi , Huang Tianyue , Si Xiaopeng , Wang Weili 
Published: October 2022

Abstract
The energy consumption and carbon dioxide emissions of tourism industry in China have become issues that cannot be ignored, putting pressure on the natural environment. This study uses Data Envelopment Analysis–Malmquist Index (MI) model to analyze the temporal and spatial evolution process of low-carbon tourism industry efficiency in Heilongjiang Province from 2010 to 2019. The results show that from 2010 to 2019, the technical efficiency (TE) of low-carbon tourism industry in 12 regions of Heilongjiang Province was significantly different and shows a growth trend. The pure technical efficiency (PTE) in Qiqihar, Jixi and Yichun had a more significant impact on the TE, and PTE had a greater impact on the development of low-carbon tourism economy in these regions. Hegang, Daqing, Shuangyashan, Kiamusze, Heihe and Suihua have a higher MI, and the TE has maintained a stable growth state overall.
A Special Tribunal for the Crime of Aggression?
Authors: Dannenbaum Tom 
Published: October 2022

Abstract
The Russian Federation is currently in the second phase of what appears to be a war of aggression against Ukraine. While Russia’s invasion is widely thought to satisfy the threshold of the crime of aggression, the routes to accountability for this crime are unclear: The International Criminal Court lacks jurisdiction and domestic courts offer an uncertain alternative. Therefore, Ukraine and a chorus of others are advocating the creation of a special tribunal. This piece explores the options as well as the arguments that speak in favour and against establishing such a special tribunal for the crime of aggression.
Demographic and environmental correlates of home ranges and long-distance movements of Mohave ground squirrels
Authors: Poessel Sharon A , Leitner Philip , Inman Richard D , Esque Todd C , Katzner Todd E 
Published: October 2022

AbstractSpace use by mammals can differ among age-classes, sexes, or seasons, and these processes are recognized as adaptive behavioral strategies. Semi-fossorial ground squirrels, in particular, have shown age- and sex-specific patterns in their aboveground movement behaviors. We studied space use of Mohave ground squirrels (Xerospermophilus mohavensis) at the Freeman Gulch study site in the central region of their range in the Mojave Desert, California. We documented the timing of their full annual cycle, investigated correlates of size of home ranges of adults and distance of long-distance movements by juveniles, and evaluated whether juvenile body masses and movements were related to interannual climatic variation. Adult males emerged from burrows and entered hibernation sooner than did adult females. Home ranges were larger for males (x¯ ± SD = 0.50 ± 0.40 km2) than females (0.05 ± 0.03 km2), especially during the mating season. Maximum distances moved by juveniles did not differ significantly between males (1.6 ± 2.3 km) and females (1.0 ± 1.8 km), and both sexes were equally likely to travel long distances from natal sites. The longest-distance movement we documented was 7.7 km by a juvenile male. Juveniles born in a year of low vegetation productivity gained significantly less mass (97 ± 7 g) and traveled shorter distances than those born in a year of higher vegetation productivity (177 ± 20 g). Our findings were similar to those documented in the Coso Range study site in the northern region of the geographic range of the species, indicating that movement patterns are similar range-wide. Mohave ground squirrels responded strongly to climate variation, and global climate change will likely result in a northward shift in suitable habitats. Informed conservation planning, therefore, will be essential for this rare, declining species.
Temporal rate of postmortem DNA degradation in archived tissue samples: evidence from liver and muscle
Authors: Amarilla-Stevens Heidi N , Stevens Richard D , Phillips Caleb D , Bradley Robert D 
Published: October 2022

AbstractGuidelines identifying best practices for harvesting tissues that lead to optimal DNA preservation are few but are important curatorial concerns for genetic resource collections. We conducted a temporal study to establish rate of DNA degradation of tissue samples extracted from field-caught museum specimens. Five individuals of Sigmodon hispidus were collected and their liver and muscle tissues were harvested. Each tissue type was sectioned into 15 subsamples, and each was preserved in liquid nitrogen at different time intervals (2, 4, 8, 16, and 32 min; 1, 2, 4, 8, and 16 h; and 1, 2, 4, 8, and 16 days) following death. DNA was extracted using an automated robotic instrument and molecular mass profiles were determined fluorometrically. Postmortem DNA degradation was continuous and dependent on time, but also was significantly affected by differences among individual cotton rats. DNA fragments of ≥10,000 base pairs in length were present in muscle samples across all time intervals, whereas DNA fragments of this size in liver samples were no longer present after 8–16 h postmortem. DNA molecular mass profiles showed that muscle samples retained 80% of their longest fragments (≥10,000 base pairs) until 1 day postmortem, whereas liver samples retained the same percentage only until 8 min after death. Although rates of decay were measured from samples in a laboratory (not field) setting, rates of decay presented here can guide field and museum workers in best practices. Results suggest that opportunistic samples, such as those from roadkill specimens, are more likely to be of use for a variety of molecular methods when muscle is preserved. Considerations of differences in rates of degradation may also guide selection of tissue types housed in genetic resource collections, especially under space-limited circumstances.