bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Radiotherapy Plus Immunotherapy and Lenvatinib for the Treatment of Recurrent Hepatocellular Carcinoma With a Right Atrium and Inferior Vena Cava Tumor Thrombus
Authors: Qian Yuting , Gong Long , Li Su , Mao Kun , Li Xianming , Liao Guixiang 
Published: May 2022

BackgroundThe treatment of hepatocellular carcinoma (HCC) with right atrium (RA) and inferior vena cava (IVC) tumor thrombi is challenging, with the standard treatment being not well established. Immunotherapy plus antiangiogenic therapy is a potentially effective treatment for patients with advanced HCC. Here, we described the case of a patient with HCC with RA and IVC tumor thrombi who achieved a successful response from radiotherapy and targeted therapy plus immunotherapy.Case SummaryA 62-year-old women presented with severe bilateral lower extremity edema identified as recurrent HCC with RA and IVC tumor thrombi based on past medical history and computed tomography. The patient received palliative radiotherapy plus pembrolizumab and lenvatinib treatment and was relieved of disease symptoms of bilateral lower extremity edema. The HCC with RA and IVC tumor thrombi shrunk, and the progression-free survival of this patient was &gt; seven months.ConclusionTumor thrombus-directed radiotherapy plus concurrent immunotherapy and targeted therapy might be a feasible and safe approach for patients with HCC with RA and IVC tumor thrombi.
Association Between Benign Ovarian Tumors and Ovarian Cancer Risk: A Meta-Analysis of Ten Epidemiological Studies
Authors: Guo Jiao , Feng Haoshen , Gu Xi 
Published: May 2022

BackgroundEpidemiological evidence on the relationship between benign ovarian tumors and ovarian cancer risk has been controversial; therefore, this systematic review and meta-analysis evaluated this association.MethodsThe PubMed and Web of Knowledge databases were searched for eligible studies published up to April 30, 2020. The study-specific risk estimates were pooled using a random-effects model.ResultsTen articles (two cohorts, seven case-control studies, and one pooled analysis of eight case-control studies) with 10331 ovarian cancer patients were included. Benign ovarian tumors were associated with an increased risk of ovarian cancer (pooled relative risk [RR]=1.39, 95% confidence interval [CI]: 1.01–1.90), with high heterogeneity among studies. The pooled RR was 2.02 (95%CI: 1.32–3.11) for two cohort studies, which was higher than the pooled result of eight case-control studies (pooled RR: 1.15; 95%CI: 0.92–1.44). When stratifying by histological type, the pooled RRs were 1.53 (95% CI: 0.37–6.29) and 3.62 (95%CI: 0.81–16.20) for serous and mucinous tumors, respectively. The pooled RRs were 1.61 (95%CI: 0.65–3.95) and 1.54 (95%CI: 1.29–1.84) for the associations of ovarian cyst with invasive and borderline cancers, respectively.ConclusionsBenign ovarian tumors were associated with an increased risk of ovarian cancer. Due to the high heterogeneity among the studies and the risks of bias, more studies are warranted to confirm these findings.
Saliva Cortisol in Girls With Functional Abdominal Pain Disorders: A Randomized Controlled Dance and Yoga Intervention
Authors: Areskoug Sandberg Elin , Duberg Anna , Lorenzon Fagerberg Ulrika , Mörelius Evalotte , Särnblad Stefan 
Published: May 2022

IntroductionFunctional abdominal pain disorders (FAPDs) are common among girls and has been associated with stress. Cortisol is one of the major stress hormones. Dance and yoga have been shown to reduce abdominal pain among girls with FAPDs.AimTo investigate the effect of an 8-month intervention with dance and yoga on cortisol levels in saliva among girls with FAPDs.MethodsA total of 121 girls aged 9–13 years with irritable bowel syndrome (IBS) or functional abdominal pain were included in the study. Participants were randomized into an intervention group and a control group. The intervention group attended a combined dance and yoga session twice a week for 8 months. Saliva samples were collected during 1 day, in the morning and evening, at baseline, and at 4 and 8 months. Subjective pain and stress were assessed as well.ResultsNo significant effects on saliva cortisol levels between groups were observed after completion of the intervention at 8 months. However, evening cortisol and evening/morning quotient were significantly reduced at 4 months in the intervention group compared to the control group (p = 0.01, p = 0.004). There was no association between cortisol quota and pain or stress.ConclusionImprovements in cortisol levels were seen in the intervention group at 4 months but did not persist until the end of the study. This indicates that dance and yoga could have a stress-reducing effect during the ongoing intervention.
Prevalence and Determinants of Wheezing and Bronchodilatation in Children With Cystic Fibrosis: A Retrospective Cohort Study
Authors: Galodé Francois , Ladipo O. , Andrieux A. , Feghali H. , Bui S. , Fayon Michael 
Published: May 2022

BackgroundMany patients with cystic fibrosis (CF) wheeze, and are dubbed as having CF-asthma. Understanding the determinants of such wheezing may avoid unnecessary treatments and open newer treatment avenues.ObjectivesMain: To evaluate the prevalence and characteristics of wheezing and a positive bronchodilatory response (BDR) in children with CF. Secondary: To identify the predictive markers and the impact of current wheezing a positive BDR.MethodsA retrospective single-center study in children with CF. We determined the characteristics of physician-reported wheeze in patients &lt;6 years, and a BDR in patients aged 6–17 years. Anthropometric, lung function, laboratory, genetic and microbiological data were recorded in all groups. Variables were compared using the Chi2and Studentt-tests, and ANOVA.Results125 preschool and 69 school-aged children and adolescents with CF were included in the study. 71.2% of patients &lt;6 years of age had had at least one episode of wheezing: 26.3% of patients were Transient Early Wheezers, 12.6% Late Onset Wheezers and 37.9% were Persistent Wheezers. The prevalence of a positive BDR was 73.5, 48.5, and 52.9% in the 6–8 years, 10–12 years, and 15–17 years age groups, respectively. Allergic factors were not predictive of wheezing in preschoolers. In the 6–8 years age group, the sum of wheal diameters of allergic skin prick tests (SPT, house dust mite + cat + dog dander) was greater in those with a BDR vs. no BDR (4 [2.0–8.8] vs. 1 [0–7.0] mm,p= 0.01). The presence ofPseudomonas aeruginosain the bronchial secretions before 3 years of age was not significantly associated with either the presence of wheezing at the age of 6 years or a BDR in school-aged children and adolescents. The proportion of homozygous p.F508del patients was significantly lower in the group of patients who had wheezed by 6 years of age (60% vs. 72.7%,p= 0.009), but higher in the 6–8 years old group with a BDR vs. no BDR (64% vs. 36%,p= 0.04). Current wheezers at 6 years had a lower mean FEV1vs. the non-current wheezers (91.5 ± 4.4% vs. 100.9 ± 2.4%;p= 0.047). Similarly, forced vital capacity (FVC) was significantly lower in the 6–8 years old group with BDR vs. no BDR (85 ± 19 vs. 101 ± 21%,p= 0.015).ConclusionWheezing and BDR are very frequent findings in children with CF. Current wheeze at the age of 6 years was associated with worse lung function. Labeling wheezing in CF as “CF-Asthma” is misleading since the determinants are different, and may lead to inappropriate prescriptions of inhaled steroids.
Vascular Anatomy in Congenital Lung Lesions—Description and Classification
Authors: Kargl Simon , Schlader Florian , Scala Mario , Kammel Julian 
Published: May 2022

BackgroundBronchopulmonary sequestration (BPS) and hybrid lesion of congenital pulmonary airway malformation (CPAM) are congenital lung lesions typically presenting with systemic vascular connection. We describe and categorize this atypical systemic vascular anatomy in congenital lung lesions.MethodsIn a medical chart review from 2005 to 2020 patients with systemic vascular connection of congenital lung lesions were identified. Clinical and radiological data were collected and compared. Two experienced pediatric radiologists reviewed postnatal thoracic contrast-enhanced computed tomography scans to describe and categorize atypical vascular anatomy. We completed our findings with a review on vascular anatomy in congenital lung lesions.ResultsA total of 21 patients with congenital lung lesions (nine extralobar BPS, five intralobar BPS, seven hybrid lesions) had systemic arterial supply; with seven of these additionally having systemic venous drainage. Origin of the feeding arteries from the aorta or aortic main branches was described as supra-diaphragmatic (descending thoracic aorta) in nine and infra-diaphragmatic in ten patients (abdominal aorta, celiac trunk). In two patients with hybrid lesions both supra- and infra-diaphragmatic arterial feeders were found. Additional systemic venous connection of supra-diaphragmatic type drains into the azygos-hemiazygos system (4/21) while the infra-diaphragmatic type (3/21) drains into caval vein, portal or splenic vein.ConclusionVarious variants of systemic arterial and venous connection of congenital lung lesions can be found. Classification of systemic arterial connection as well as venous drainage of congenital lung lesions as supra-diaphragmatic and infra-diaphragmatic types is intuitive, simple and may be important for the surgeon to avoid unanticipated situations and to perform safe resections.
Immune Checkpoint Inhibitor-Related Myositis Overlapping With Myocarditis: An Institutional Case Series and a Systematic Review of Literature
Authors: Nakagomi Yuki , Tajiri Kazuko , Shimada Saori , Li Siqi , Inoue Keiko , Murakata Yoshiko , Murata Momoko , Sakai Shunsuke , Sato Kimi , Ieda Masaki 
Published: May 2022

Background: Immune checkpoint inhibitor (ICI)-related myositis with myocarditis is a rare but potentially fatal immune-related adverse event. However, its clinical features, response to immunosuppressive treatment, and prognosis remain poorly understood. Here, we describe the clinical course of patients with ICI-related myositis overlapping with myocarditis treated at our institution and a systematic review focusing on the response to immunosuppressive therapy.Methods: We identified patients who developed ICI-induced myositis with myocarditis and were treated at our hospital using a retrospective chart review of electronic medical records. For the systematic review, studies reporting ICI-induced myositis with myocarditis were identified using the Cochrane Library and PubMed databases.Results: Of the 625 patients treated with ICIs, four developed myositis with concurrent myocarditis. All the patients received immunosuppressive therapy. We assessed the activity of myocarditis and myositis based on temporal changes in troponin and creatine kinase (CK) levels. In all patients, peak troponin values appeared later than the peak CK values (median, 17 days). The median time from the start of ICI therapy to the peak of troponin and CK levels was 42.5 and 28 days, respectively. In all patients, CK levels decreased rapidly and steadily after the initiation of immunosuppressants. However, troponin levels were unstable and increased. In all patients, CK levels normalized within one month (range, 12–27 days), but troponin levels took several months to normalize (range, 84–161 days). Fourteen cases of ICI-related myositis with myocarditis were included in the systematic review. Of the 14 cases, 12 (86%) had their CK level decreased after the initial steroid treatment, but the troponin level increased and was higher than that before the start of treatment. In addition, the peak troponin values appeared later than the peak CK values (a median of 6.5 days). Eight (89%) of 9 long-term follow-up patients had troponin levels above the normal range even after CK normalization.Conclusion: In most cases of ICI-related myositis with myocarditis, troponin levels increased after the initial steroid treatment despite decreased CK levels, and exceeded pre-steroid levels. In addition, troponin remained elevated for several months after CK normalized.
A Thin-Film Thermal Meta-Device With Dual Function of Thermal Shield and Generation Based on an Artificially Tilted Structure
Authors: Zhang Qingqing , Yuan Junyu , Zhu Wei , Deng Yuan 
Published: May 2022

A thin-film thermal meta-device with a dual-function of thermal shield and generation is proposed and fabricated in this work. The tilted layered structure composed of thermoelectric materials with low thermal conductivity and metal materials with high thermal conductivity is designed to realize the orientation of the incident heat flux and the utilization of heat energy based on the Seebeck effect of the materials. The constructed transverse thin-film thermoelectric device with a Bi2Te3/Cu-layered structure can achieve a maximum output voltage of 20.4 mV and a maximum output power of 7.39 μW at a temperature difference of 80 K. On this basis, the dual-functional film meta-device based on transformation thermodynamics is capable of realizing a heat flux shielding in the central area and generating a transverse output voltage. The experimental results also indicate that there exists a well linear relationship between the output voltage of the meta-device and the temperature difference, which can be extended to accurately monitor the temperature of the central area. This work provides a certain reference for the development of a new class of thermoelectric devices with thermal protection and temperature detection capability.
Social Capital and Lifestyle Impacts on Mental Health in University Students in Colombia: An Observational Study
Authors: Sotaquirá Lina , Backhaus Insa , Sotaquirá Paula , Pinilla-Roncancio Mónica , González-Uribe Catalina , Bernal Raquel , Galeano Juan José , Mejia Natalia , La Torre Giuseppe , Trujillo-Maza Elena M. , Suárez Daniel E. , Duperly John , Ramirez Varela Andrea 
Published: May 2022

IntroductionFor young adults, the first year of higher education represents a transition period into adulthood associated with an increased risk of developing depression, anxiety, and stress, contributing to deteriorating physical and mental health. The present study aimed to analyze the relationship between depressive symptoms and social capital and lifestyles among Colombian university students.MethodsIn 2020, a longitudinal repeated measures study was conducted on first year students at Universidad de los Andes in Bogota, Colombia. The study was conceptualized and approved by the university before the COVID-19 pandemic appeared. Each student completed a self-administered questionnaire including questions on sociodemographic characteristics, depressive symptoms, perceived stress, social capital, and lifestyles. The study's pilot was conducted in November 2019, and the two measurement points were in January 2020 (wave 1, before the COVID-19 pandemic was declared) and in August 2020 (wave 2, during the COVID-19 pandemic). A binary logistic regression analysis was performed to assess the relationship between depressive symptoms, perceived stress, social capital, and lifestyles.FindingsA total of 609 first year students (response rate = 58.11%) participated in wave 1, and 42% of the participants showed signs of clinically relevant depressive symptoms. In wave 2, despite the difficulties encountered in collecting data due to the COVID-19 pandemic, 216 students from wave 1 participated (35.47%). An increase in a sedentary lifestyle was observed (31.49%). We found that cognitive and behavioral social capital levels decreased by 12.03 and 24.54%, respectively. In addition, we observed a 6.5% increase in students with clinically relevant depressive symptoms compared to wave 1. A low level of behavioral [OR: 1.88; 95% CI (1.16, 3.04)] social capital was associated with clinically relevant depressive symptoms.ConclusionThe health of university students continues to be a public health concern. The study suggests that social capital may play an important role in preventing depressive symptoms. Therefore, universities should put effort into programs that bring students together and promote the creation of social capital.
Quality of the Healthcare Services During COVID-19 Pandemic in Selected European Countries
Authors: Tuczyńska Magdalena , Staszewski Rafał , Matthews-Kozanecka Maja , Żok Agnieszka , Baum Ewa 
Published: May 2022

BackgroundThere are several definitions of the quality of healthcare services. It may be defined as a level of value provided by any health care resource, as determined by some measurement. Scientists use a variety of quality measures to attempt to determine health care quality. They use special indicators or based on a patients' or healthcare professional's perception. This article aims to provide a short review of the available data on the quality of healthcare services in selected European countries during the COVID-19 pandemic.MethodologyThe research was done by the use of online databases such as PubMed, Google Scholar, and Science Direct. All the studies focused on the quality of healthcare services, yet the studies used different methods to measure this quality. In addition, the results of the authors' survey on the assessment of the quality of healthcare services before and during the COVID-19 pandemic were presented.ResultsAmong twelve studies, four were from the United Kingdom and one each of Catalonia, Italy, Sweden, Poland, Netherlands, France, Germany, Belgium. Patients in the United Kingdom felt that the quality of services was good during the pandemic, whereas the quality declined in the other studies cited. The results of our research also revealed a decrease in the quality of healthcare services provided.ConclusionsNevertheless the development of telemedicine has had a positive impact on the quality of healthcare services. The COVID-19 pandemic has undoubtedly affected most European countries' quality of healthcare services.
The Role of Surgical Expertise and Surgical Access in Retroperitoneal Sarcoma Resection – A Retrospective Study
Authors: Aeschbacher P. , Kollár A. , Candinas D. , Beldi G. , Lachenmayer A. 
Published: May 2022

BackgroundRetroperitoneal sarcoma (RPS) is a rare disease often requiring multi-visceral and wide margin resections for which a resection in a sarcoma center is advised. Midline incision seems to be the access of choice. However, up to now there is no evidence for the best surgical access. This study aimed to analyze the oncological outcome according to the surgical expertise and also the incision used for the resection.MethodsAll patients treated for RPS between 2007 and 2018 at the Department of Visceral Surgery and Medicine of the University Hospital Bern and receiving a RPS resection in curative intent were included. Patient- and treatment specific factors as well as local recurrence-free, disease-free and overall survival were analyzed in correlation to the hospital type where the resection occurred.ResultsThirty-five patients were treated for RPS at our center. The majority received their primary RPS resection at a sarcoma center (SC = 23) the rest of the resection were performed in a non-sarcoma center (non-SC = 12). Median tumor size was 24 cm. Resections were performed via a midline laparotomy (ML = 31) or flank incision (FI = 4). All patients with a primary FI (n = 4) were operated in a non-SC (p = 0.003). No patient operated at a non-SC received a multivisceral resection (p = 0.004). Incomplete resection (R2) was observed more often when resection was done in a non-SC (p = 0.013). Resection at a non-SC was significantly associated with worse recurrence-free survival and disease-free survival after R0/1 resection (2 vs 17 months; Log Rank p-value = 0.02 respectively 2 vs 15 months; Log Rank p-value &lt; 0.001).ConclusionsResection at a non-SC is associated with more incomplete resection and worse outcome in RPS surgery. Inadequate access, such as FI, may prevent complete resection and multivisceral resection if indicated and demonstrates the importance of surgical expertise in the outcome of RPS resection.
Studi Komparasi Implementasi Bimbingan Perkawinan Sebagai Upaya Untuk Mencegah Perceraian (Studi Kasus di KUA Kecamatan Jepara dan KUA Donorojo)
Authors: Misbachuddin Misbachuddin 
Published: May 2022

Problems in marriage and family are very diverse, from small problems to big problems resulting in divorce, in other words, there are causes that the marriage is not as expected. Marriage requires good mental, financial and knowledge preparation. Therefore, it is necessary to have marital guidance before carrying out marriage in order to know the future marital life and prepare for domestic life. This type of research is qualitative through descriptive nature. In this study, the author intends to find out how the differences in the implementation and effectiveness of marriage guidance in KUA Jepara and Donorojo Districts. Data collection was carried out by means of observation, interview and documentation techniques. The information in this research is the head of the KUA, the head of the KUA as well as the marriage guidance supervisor and the bride and groom who are conducting the marriage guidance. The results of this study indicate that the process of implementing marriage guidance at KUA Jepara District has two targets, namely for the prospective bride and groom after marriage, while the process of implementing marriage guidance at KUA Donorojo District only focuses on the prospective bride and groom. The implementation of marriage guidance at KUA Jepara and Donorojo Subdistricts is not yet fully effective because there are still many inhibiting factors in the process of implementing marriage guidance. Permasalahan dalam perkawinan dan keluarga sangat beragam dari masalah yang kecil hingga masalah yang besar mengakibatkan perceraian, dengan kata lain ada yang menyebabkan perkawinan itu tidak sesuai dengan yang diharapkan. Dalam perkawinan dibutuhkan persiapan baik mental, financial dan pengetahuan tentang perkawinan. Oleh sebab itu maka perlulah adanya bimbingan perkawinan sebelum melaksanakan perkawinan agar mengetahui kehidupan perkawinan kelak dan mempersiapkan diri untuk kehidupan rumah tangga. Jenis kajian ini adalah kualitatif melalui sifat diskriptif. Pada kajian ini penulis bermaksud untuk mengetahui bagaimana perbedaan pelaksanaan dan efektivitas bimbingan perkawinan di KUA Kecamatan Jepara dan Donorojo. Pengumpulan data dilakukan dengan teknik observasi, wawancara, dan dokumentasi. Informasi dalampenelitian ini adalah Kepala KUA, penghulu sekaligus pembimbing bimbingan perkawinan serta calon pengantin yang melakukan bimbingan perkawinan. Hasil kajian ini menunjukan proses pelaksanaan bimbingan perkawinan di KUA Kecamatan Jepara memiliki dua sasaran yaitu bagi calon pengantin dan pasangan pengantin setelah menikah, sedangkan proses pelaksanaan bimbingan perkawinan di KUA Kecamatan Donorojo hanya berfokus pada pasangan calon pengantin. Pelaksanaan bimbingan perkawinan di KUA Ke camatan Jepara dan Donorojo belum sepenuhnya efektif karena masih banyak faktor penghambat dalam proses pelaksanaan bimbingan perkawinan.