bluuebunny/crossref_metadata_2025_split huggingface dataset:
AVALIAÇÃO DA PREVALÊNCIA DE SÍFILIS NAS CIDADES DE PORTO ALEGRE E ALVORADA DA REGIÃO SUL DO BRASIL
Authors: Abreu Ingrid Telles de , Jacociunas Laura Vicedo 
Published: February 2022

Introdução: A Sífilis é uma doença infecciosa de evolução lenta causada pela bactéria Treponema pallidum com características clínicas, imunológicas e histopatológicas distintas que alterna períodos sintomáticos e assintomáticos. No Brasil, dados epidemiológicos demonstram um aumento significativo do número de casos de sífilis congênita e adquirida, nos últimos anos, sendo um importante problema de saúde pública. O presente estudo objetivou avaliar a prevalência de sífilis nas cidades de Porto Alegre e Alvorada da região sul do Brasil.Metódos: Análise de dados de pacientes atendidos pelo Sistema Único de Saúde nas cidades de Porto Alegre e Alvorada, contidos no banco de dados de um laboratório de grande porte, no período compreendido entre os anos de 2018 a 2019. Os dados obtidos foram transpostos para uma planilha de EXCEL, e posteriormente analisados no programa StatisticalPackage for Social Sciences(SPSS), considerando-se com nível de significância p0,05.Resultados: Os resultados obtidos demonstram que a prevalência da sífilis na população estudada foi de 19,2% em Porto Alegre e 18,2% em Alvorada. Foi observado ainda aumento significativo, em ambas as cidades, de um ano para o outro, além da patologia demonstrar-se mais prevalente em mulheres no período estudado.Conclusões: O Brasil vem ampliando esforços na luta contra as epidemias e investe no desenvolvimento de ações para a promoção da saúde, a prevenção das infecções. Desta forma, mais estudos em períodos maiores devem ser desenvolvidos para continuar se estimando a prevalência desta doença bem como para traçar medidas de prevenção e controle.
Scleredema — Rare skin manifestation in diabetic
Authors: Nimbolkar Janardan , Thacker Hemant , Gandhi Bhavesh 
Published: February 2022

Scleredema is a connective tissue disorder of unknown etiology. A 44 years diabetic, obese female patient, admitted with edema feet, erythematous, indurated hyper pigmentation with ascending progression to trunk which rapidly transformed to painless dark pigmented blister and hard non-pitting edema of anterior abdominal wall. In a week time. She was managed with broad spectrum antibiotics, was aggressively diuresed along with albumin infusion. Her skin biopsy was done which revealed scleredema. She had poor LV function due to volume overload or cardiomyopathy. After initial improvement on 14 day, she suddenly developed fulminant septicemia. Within hours, she displayed multi organ dysfunction and the heart and kidney which were already delicately balanced, decompensated. There was intractable arrhythmias and severe LV dysfunction, renal failure and ischemic hepatitis following severe hypotension. Scleredema in diabetic subjects, can be an ominous sign for producing fulminant multiorgan dysfunction and can present as cardiomyopathy, myocarditis, liver dysfunction etc., and these patients are more prone to infections or may be vice versa. Scleredema can be considered as a marker of fulminant illness in immunocompromised individuals. There is a need for treatment protocols or research into this a rather enigmatic but rare illness.
Pengaruh Husnuzzhan Terhadap Perilaku Prososial Pada Mahasiswa UIN Antasari Banjarmasin
Authors: Kiftiah Mariatul , Mubarak Mubarak , Hairina Yulia 
Published: February 2022

This study aims to determine the effect of husnuzzhan on prosocial behavior in students of UIN Antasari Banjarmasin. This type of research is field research with a quantitative approach. The population in this study were active students of UIN Antasari Banjarmasin class 2018 and 2019. The sampling technique uesd was purposive sampling. The sample of this study amounted to 98 people. Based on the research conducted, the results obtained: 1) The level of husnuzzhan in the high category was 18 people (18,4%), while 68 people (69,4%) and low 12 people (12,2%). 2) The level of prosocial behavior in the high category was 11 people (11,2%), while 73 people (75,5%) and low 14 people (14,3%). 3) There is a husnuzzhan influence on prosocial behavior in UIN Antasari Banjarmasin students with a significance value of 0,000 (sig < 0,05) and a effective contribution of 21,9%.
Students' Cognitive Analysis using Rasch Modeling as an Assessment for Planning of Strategies in Chemistry Learning
Authors: Rusmansyah Rusmansyah , Almubarak Almubarak 
Published: February 2022

<p>Rasch modelling based on assessment can help teachers analyze the students' cognitive knowledge level and development. However,<strong> </strong>teachers are considered unsuccessful in teaching where the achievement of indicators in learning science, such as chemistry, is not holistically actualized. This study aimed to analyze High School students' knowledge in Banjarmasin City, especially on students' knowledge (cognitive aspect), using the Rasch modelling data analysis technique and exploring how chemical learning strategies are planned based on the symptoms of the data obtained. The data collection technique used a dichotomous format test technique (multiple choices). The research method used was descriptive with a quantitative approach to examine Rasch's various data, which was then interpreted qualitatively to describe the issues raised. The study results show that person reliability (students) based on Rasch modelling anal­ysis is +0.79, and <em>item reliability </em>is<em> </em>+0.98, where the value indicates that the consistency of the participant response pattern is "sufficient." Then, the <em>mean person measure </em>is<em> </em>-0.07, while the mean item is 0.00. It means that the participants' "mean value" is below the "mean value" of the item that the students' ability is below the item's ability. The Rasch data's recapitulation value showed that the response patterns of various data symptoms and those data were interpreted. It showed students' knowledge of atomic structure material was still considered low based on the Rasch model criteria. This is a reference for making appropriate chemical learning strategy plans to improve their knowledge. In conclusion, Rasch modelling-based assessment is effectively used in analyzing students' (cognitive) ability on atomic structure material. These results produce a strategic plan like what in chemistry learning such as the importance of conducting further diag­noses using misconception tests, identifying students' learning styles, constructing stu­dents' knowledge through the concept of chemical representation, and developing appropriate learning media according to their needs (students).</p>
Phytochemical Screening of Honey Pineapple Peel Extract and Its Application as an Antibacterial Additive in Dish Soap Formulation
Authors: VH Elfi Susanti , Mulyani Sri , Ariani Sri Retno Dwi , Utomo Suryadi Budi , Antrakusuma Bayu 
Published: February 2022

<p><a name="_Hlk55556551"></a><span lang="EN-US">This research aims to scientifically develop bioactive compounds from honey pineapple peel and develop a dish soap formulation with extract additives of honey pineapple peel that can be antibacterial. </span><span lang="EN-US">The research was conducted in stages, namely process of extracting honey pineapple peel was carried out by the maceration method using 96% ethanol as a solvent</span><span lang="IN">, p</span><span lang="EN-US">hytochemical screening of the ethanol extract of honey pineapple peel was done to determine the class of compounds contained in the extract</span><span lang="IN">, and a</span><span lang="EN-US">pplication of honey pineapple peel extract in dish soap formulation was to obtain a dish soap formulation with optimal antibacterial activity. Testing the ability of dish soap products to inhibit <em>S. aureus</em> bacteria was performed by the method of filter paper disc diffusion. </span><span lang="EN-US">The results revealed that the ethanol extract of honey pineapple peel contained alkaloids, flavonoids, tannins, and saponins. The ethanol extract of honey pineapple peel has been applied in a dish soap formulation and tested for the antibacterial activity of <em>S. aureus</em>. Antibacterial test results showed that the dish soap formulation with the addition of 5% pineapple peel extract provided strong antibacterial activity, indicated by a precise zone formation of 12.60 mm</span></p>
The Effect of Energy Minimization on The Molecular Docking of Acetone-Based Oxindole Derivatives
Authors: Fadlan Arif , Nusantoro Yesaya Reformyada 
Published: February 2022

<p>In silico study by molecular docking, drug discovery, and virtual screening are useful for obtaining compounds with promising biological activity. The force fields energy minimization in molecular docking is the overall process to produce better geometry estimation and ligand-receptor affinity. In this study, the divide and conquer algorithm based on the Mikowski matrix in MarvinSketch and the conjugate gradient algorithm of Open Babel were used to minimise acetone-based oxindole derivatives in indoleamine 2,3-dioxygenase 1 (IDO1). The results showed that the binding energy produced by MarvinSketch was generally better than the binding energy obtained with Open Babel. The visualization of molecular docking results indicated that the poses and hydrogen bonding, halogen bonding and π-π interactions are different between MarvinSketch, Open Babel, and no energy minimization. The results revealed that energy minimization affects the molecular docking results.</p><p> </p>
Fragment size and dynamics of EGFR-mutated tumor-derived DNA provide prognostic information regarding EGFR-TKI efficacy in patients with EGFR-mutated NSCLC
Authors: Kunimasa Kei , Nishino Kazumi , Sato Yoshiharu , Mori Masahide , Ihara Shoichi , Suzuki Hidekazu , Nagatomo Izumi , Kumagai Toru , Imamura Fumio 
Published: February 2022

Abstract
Circulating tumor DNA (ctDNA)-based next-generation sequencing (NGS) is a complementary and alternative test to tissue-based NGS. e performed NGS analysis of ctDNA samples collected from patients with EGFR-mutated non-small cell lung cancer (NSCLC) who received osimertinib; the samples were collected after second-line treatment, before osimertinib treatment, one week and one month after osimertinib treatment, and at the time of resistance formation, and the correlation with osimertinib efficacy was examined. From January to December 2018, 34 patients with EGFR-mutated NSCLC harboring EGFR T790M mutations were enrolled, and a total of 132 peripheral blood samples were collected. The fragment sizes of EGFR-mutated ctDNAs were significantly shorter than those of their corresponding normal fragments. Osimertinib treatment of EGFR-mutated patients with shorter EGFR-mutated ctDNA fragments resulted in shorter progression-free survival (PFS). Disappearance timing of EGFR-mutated fragment fractions and clonal evolution patterns (new driver mutation group, additional mutation group vs. attenuation group) were each associated with osimertinib PFS, although multivariate analysis revealed that only shorter EGFR-mutated ctDNA fragments were associated with osimertinib PFS. EGFR-mutated ctDNA fragment size, disappearance timing, and clonal evolution pattern were related to the effects of osimertinib. In particular, short EGFR-mutated ctDNA fragmentation may be closely related to osimertinib efficacy prediction.
Impact of Climate Change on Yields of Wheat in Ethiopia: An Augmented Cobb-Douglas Production Function Approach
Authors: Tirfi Abera Gayesa , Oyekale Abayomi Samuel 
Published: February 2022

Abstract
The study analyzed the impact of climate change on yields of wheat crop in Ethiopia by employing Cobb-Douglas Production Function Approach using time series data for the period 1981 – 2018. The study confirmed that long-season rainfall and crop growing season maximum temperature have negative and significant effects on wheat yield. The result implies that a rise in maximum temperature during crop growing period and variation in long-season rainfall could have adverse impact on yield of wheat crop. The findings further showed that fertilizers, improved seed, and irrigation applied on wheat crop have all positive and significant impact on yield of wheat, implying that use of fertilizer, improved seed and irrigation inputs have vital role in increasing yields of wheat crop. Conversely, the study indicated that land area cultivated under wheat cropping showed negative and significant impact on yield of wheat crop, implying that any area expansion under wheat crop production would have negative impact. In view of the findings of the study, it is recommended that adaptation strategies that could offset the adverse effects of climate change should be designed and adopted. An increased use of irrigation is recommended, particularly in potential lowland areas to mitigate the adverse effect of climate sensitivity on wheat crop. Use of improved wheat seed varieties of short duration and tolerant to warm and moisture stress conditions are recommended to increase productivity and production of wheat crop. Increased use of fertilizers in cooler mid and highland areas can be another option to increase the productivity of wheat crop in Ethiopia.
Influence of the fibre laser parameters on the surface texturing of 420 stainless steel
Authors: Cunha Ângela , Marques Ana , Bartolomeu Flávio , Silva Filipe Samuel , Gasik Michael , Trindade Bruno , Carvalho Óscar 
Published: February 2022

Abstract
The surface of an annealed 420 stainless steel plate was textured using a fibre laser in this work. Four hundred textures were produced from eighty different combinations of processing parameters (laser power, scan speed, line spacing and number of passes). The most promising textures (fourteen combinations of the processing parameters) were obtained with laser power values of 16 and 64 %, scanning speeds up to 2,000 mm/s, number of passes of 8 or higher and line spacings of 40 and 50 µm. The lower the laser power, the lower the scanning speed and the high number of passes and line spacings were required for a suitable ablation process. High laser powers were responsible for the dissolution of the chromium carbides in the laser tracks (top and edges of the unmachined areas). The hardness of these regions was 320 ± 11 HV against 255 ± 5 HV for the unmachined zones.
Spatiotemporal drought analysis in Bangladesh using the standardized precipitation index (SPI) and standardized precipitation evapotranspiration index (SPEI)
Authors: Kamruzzaman Mohammad , Almazroui Mansour , Salam MA , Mondol Anarul Haque , Rahman Md. Mizanur , Deb Limon , Kunda Polash Kumar , zaman Md. Asad Uz , I Abu Reza Md.Toufiqul 
Published: February 2022

Abstract
The lack of precipitation for an extended period is what meteorologists call a drought, and it results in low soil moisture and crop water stress. Drought has become one of the most important global challenges due to inadequate water supplies. Drought monitoring is frequently conducted using the SPI (standardized precipitation index) and the SPEI (standardized precipitation evapotranspiration index). The goal of this work is to use SPI and SPEI to investigate the differences in drought characteristics across different physiognomy types in Bangladesh and to highlight how drought characteristics change over time and spatial scales when considering different geomorphologies. This study used monthly precipitation and temperature data from 29 metrological stations for 39 years (1980–2018) for calculating SPI and SPEI values. To determine the significance of drought characteristic trends over different temporal and spatial scales, the modified Mann–Kendall trend test and multivariable linear regression (MLR) techniques were used. The results are as follows: (1) Overall, an increasing dry trend was found in Eastern hill regions, whereas decreasing trends were found rest of the regions in all time scale (range is from − 0.008 year−1 to − 0.015 year−1 for 3-month time scale). However, except for the one-month time scale, the statistically significant trend was identified mostly in the north-central and northeast regions, indicating that drought patterns migrate from the northwest to the center region. (2) Drought intensity increased gradually from the southern to the northern regions (1.26–1.56), and drought events occurred predominantly in the northwestern regions (27–30 times), indicating that drought meteorological hotspots were primarily concentrated in the Barind Tract and Tista River basin over time. (3) According to the MLR, longitude and maximum temperature can both influence precipitation. Findings can be used to improve drought evaluation, hazard management, and application policymaking in Bangladesh. This has implications for agricultural catastrophe prevention and mitigation.
Evidence Linking Stunting to Economic Outcomes in the SAARC Region: a Systematic Review
Authors: Nasser Minnat Seema , Akhlaq Ather , Ali Hijaz , Nasser Dawood 
Published: February 2022

Abstract
Background

At present, South Asian Association for Regional Coorporation (SAARC) countries have tremendous pressure on child stunting along with the impact it is making on economic growth. World Health Organization (WHO), United Nations International Children’s Emergency Fund (UNICEF) and The World Bank (WB) have emphasized for this region to reduce stunting by 40%. The objective of this paper is to analyzed the impact of stunting on economic outcomes in SAARC countries so that to scale up policies and programs aiming to reduce child stunting.
Methods

The systematic review has assessed five international databases; PubMed, JSTOR, Cochrane Library, Web of Science and CINAHL Plus for published, unpublished, and on-going research till the year 2020. Grey literature is searched using Google Scholar and Google search engines. The systematic review registration number in PROSPERO is CRD42021230279.
Result

Thirty-three studies matched the criteria. Most quantitative studies link stunting with economic repercussions. Three investigations found no or a weak link between the two. Nutritional intervention synthesis predicts a 12 percent return, a 5:1-6:1 benefit-cost ratio, and a 14mm height gain. A 1 cm increase in height increases pay by 4% for men and 6% for women. Stunting caused a 5%-7% income penalty and lower lifetime pay. Studies show that a 10% increase in agricultural growth reduces stunting by 9.6%, while a 10% increase in non-agricultural growth reduces stunting by 8.4%.
Conclusion

To reduce stunting prevalence, policies should be scaled up, as well as targeted and structural interventions are needed.
Improving ICS security through Honeynets and Machine Learning techniques
Authors: Ananbeh Obieda , Alomari Rund , Daniell Austin 
Published: February 2022

Abstract
Abstract The internet of things(IoT), the Industrial Internet of Things (IIoT), and Cyber-Physical Systems (CPS) can be seen everywhere, Home applications, Buildings, Cars, Space Industry, Military, Health Care, and in many other fields. On the other hand, they become an easier target for attackers, due to many reasons including the limitation of hardware, so from that point, companies start working to build a secure systems by keep themselves updated about their system threats and vulnerabilities, and also by studying how the attackers can gets into their system, how they act, what is the attack flow, and also the identity of the attackers by trapping and tricking them into believing that they have got access to the actual system or assets . And that’s what it's called a Honeypot. [1] As the technology keeps changing and becomes more powerful, so do the attackers, and for that reason companies should use new techniques to enhance Honeypots efficacy by making it undetectable by cybercriminals, more usable and make use of the information that the honeypots gather in a more efficient way. Moreover, Machine Learning (ML) techniques are able to provide intelligence to IoT, IIoT, and ICS systems and networks, and enhance its ability to deal with various security problems, hence, in this research, we are developing a new solution that improves the architecture of SCADA (An ICS System) by adding CamouflageNet Honeynet into it and ML techniques, in order to defend and acquisition system security performance.
Geographical variation in common orthopedic procedures in Norway: a cross-sectional population based study of 175,973 procedures
Authors: Holsen Maria , Hovind Veronica , Bedane Haji Kedir , Osvoll Knut Ivar , Gjertsen Jan-Erik , Furnes Ove Nord , Walsh Mary E , Ingebrigtsen Tor 
Published: February 2022

Abstract
Background and purposeStandardized surgery rates for common orthopedic procedures vary across geographical areas in Norway. We explored whether area-level factors related to demand and supply in publicly funded healthcare are associated with geographical variation in surgery rates for six common orthopedic procedures. Patients and methodsCross-sectional population based study of hospital referral areas in Norway. We included all adult admissions for arthroscopy for degenerative knee disease, arthroplasty for osteoarthritis of the knee and hip, surgical treatment for hip fracture, and decompression with or without fusion for lumbar disc herniation and lumbar spinal stenosis in 2012-2016, a total of 175,973 admissions. Variation in age and sex standardized rates was estimated using extremal quotients, coefficients of variation and systematic components of variance. Association between surgery rates and urbanity, unemployment, low-income, high level of education, and mortality, was explored with linear regression analyses. ResultsKnee arthroscopy showed highest level of variation (SCV 10.3) and decreased in numbers. Variation was considerable for spine surgery (3.8-4.9), moderate to low for arthroplasty procedures (0.8-2.6), and small for hip fracture surgery (0.2). Association between surgery rates and demand/supply factors were weak for knee arthroscopy and spine surgery. Rates for arthroplasty, and hip fracture surgery were not associated with supply/demand factors included.InterpretationArthroscopy for degenerative knee disease decreased in line with guidelines, but showed high variation of surgery rates. Factors reflecting supply/demand have a weak association to orthopedic surgery rates at area-level. Whether this reflects the equity of universal health care services, or if area-level factors are not detailed enough to detect an existing association, needs further exploring.
The effect of household practices on the deterioration of microbial quality of drinking water between source and point of use in Murewa district, Zimbabwe
Authors: Makokove Rameck , Macherera Margaret , Kativhu Tendai , Gudo Demetria Fungai 
Published: February 2022

Abstract
Access to safe drinking water is a key determinant of public health and is considered a basic human right essential to avert waterborne diseases. Understanding the association between household drinking water handling practices and the bacteriological quality of water at the point of use is critical since water quality may deteriorate between source and point of use. This study aimed at determining this association in Murewa district in Zimbabwe. Interviews were conducted with 381 household heads and hygiene practices were observed at selected households. Logistic regression analysis was used to examine the association between household drinking water handling practices and independent variables. The variables that were significantly associated with safe water at the point of use were tertiary education (p = 0.006), monthly income (p = 0.005), cleanliness of water collection containers (p = 0.011) and the method of drawing water from containers (p = 0.001). There is a need to intensify health and hygiene education, emphasising the importance of hygienic water handling practices, cleaning of collection containers and hygienic drawing of water from storage containers. The integration of income-generating activities into WASH projects should be strengthened to enable the acquisition of water collection and storage containers that can safeguard the quality of water between collection and consumption.