bluuebunny/crossref_metadata_2025_split huggingface dataset:
La Figura del Sabio Como Modelo Integral de Conocimiento y Conducta en la Filosofía Antigua
Authors: Silva Trinidad 
Published: March 2022

Abstract
From the significance of the sage in ancient philosophy and the emergence of the notion of wisdom in contemporary psychology, I propose to reevaluate the role of the wise man as integral model of knowledge and action in ancient philosophy. I claim that this model is rooted in the Greek tradition from archaic literature, but it is not a central element in the philosophy of the classical period (i.e., Plato and Aristotle) as it is in Hellenistic philosophy, particularly with the Stoics. The analysis includes an assessment of the conditions allowing a theory that offers the figure of the wise man as a guiding model of both knowledge and action. For this, I consider three relevant criteria: the wise man is human (even if similar to god), he proves to be integrally wise (without excluding theory from praxis) and his wisdom is useful (because of his advice or example).
Mean State of the Northern Hemisphere Stratospheric Polar Vortex in Three Generations of CMIP Models
Authors: Rao Jian , Garfinkel Chaim I. , Wu Tongwen , Lu Yixiong , Chu Min 
Published: March 2022

Abstract
Progress and persistent biases in the simulation of the stratospheric polar vortex from three generations of Coupled Model Intercomparison Projects (CMIPs) are assessed. On average, the stratospheric cold bias is largest in CMIP3, but is improved in CMIP5 and CMIP6. The climatological ridge in the stratosphere over the North Pacific is underestimated persistently across CMIPs. Four parameters of the stratospheric polar vortex are evaluated among models and among CMIPs, and some common biases are identified for most models, including the too-large size of the vortex periphery, overstrong strength, too-small aspect ratio of the vortex shape, and too-westward displaced a vortex centroid. Intermodel spread in some parameters is highly correlated with the sea surface temperature (SST) bias in northern tropical oceans. Namely, a cold SST bias in the northern tropical Pacific is associated with a too-strong and too-large polar vortex, and a cold SST bias in the northern tropical Atlantic seems to be related to the westward bias of the vortex centroid. The implications of biases in the mean state of the vortex for stratospheric events such as sudden stratospheric warmings (SSWs) are also identified in this study. Models with a climatological vortex that is too strong, has too low an aspect ratio, or has a westward-biased centroid usually produce fewer SSWs, whereas ones with weaker strength, high aspect ratio, and eastward-biased centroid produce more. Based on the multimodel mean, the biases of all parameters have improved across three generations of CMIPs, although persistent biases in some individual models exist across CMIPs. Intermodel relationships between the polar vortex and SST highlights the important role of the SST simulation for the stratosphere.
A discrete output feedback 2-SMC using Linear Matrix Inequalities and adaptive switching gain approaches: Real application on a chemical reactor
Authors: Dehri Khadija , Messaoud Anis , Ben Abdennour Ridha 
Published: March 2022

The chattering phenomenon is one of the most pervasive problems in sliding mode control (SMC), especially for discrete time applications. In this paper, we propose a new discrete output feedback second order sliding mode control (DOF2SMC). The design of this controller is based on the Linear Matrix Inequalities (LMI) approach. Then, an adaptive switching gain (ASG) is incorporated into the discontinuous part of the controller to obtain good closed loop performance in terms of tracking and reducing chattering in the case of systems subject to internal and external disturbances. Simulation results of a steer-by-wire (SBW) system show the effectiveness of the proposed DOF2SMC with ASG. To validate, once again, the performance of the proposed control system, an experimental validation on a transesterification reactor is presented. The obtained results show good closed loop performance.
Metabolic Syndrome and Breast Cancer Molecular Subtypes: An Observational Patient Study
Authors: Ademi-Islami Dafina , Manxhuka-Kerliu Suzana , Tarifa-Koroveshi Dhurata , Koliqi Rozafa , Mujaj Blerim 
Published: March 2022

Background: Breast cancer molecular subtypes share various prognostic profiles, and luminal A molecular subtypes have a better prognosis compared with other molecular subtypes. However, whether metabolic syndrome or individual risk factors of metabolic syndrome influence on the development of molecular subtype remains elusive. We aimed to assess the association between metabolic syndrome risk factors and breast cancer molecular subtypes among patients with metabolic syndrome in a clinical setting. Methods: In total, 101 breast cancer patients with mean age, 58.4 ± 8.5 years, and overt metabolic syndrome prospectively were recruited. Immunohistochemistry procedure was used to determine molecular subtypes. Assessment of clinical, biochemical, and anthropometric parameters was performed. Logistic regression analysis was used to assess the relationship between risk factors and breast cancer molecular subtypes categories. A similar approach was used to assess the relation between breast cancer molecular subtypes and menopause. Results: Comparison of metabolic syndrome individual risk factors according to breast cancer molecular subtypes no statistical difference was found for systolic ( P = .33) and diastolic blood pressure ( P = .17), fasting glucose ( P = .77), triglycerides ( P = .62), high-density lipoprotein ( P = .33), body mass index ( P = .87), and waist circumference ( P = .81). A positive trend was found between high-density lipoprotein and HER2+. No association was found with other risk factors. Moreover, an association was found between HER2+ categories and menopause. Conclusion: In breast cancer patients with metabolic syndrome, we observed an increased trend between high-density lipoprotein and HER2+ molecular subtype, suggesting that underlying dyslipidemia may favor poor prognosis. HER2+ was associated with menopause which may influence further expression of HER2+ .
Lifestyle Modification Practice and Associated Factors Among Diagnosed Hypertensive Patients in Selected Hospitals in Central Gondar Zone
Authors: Smachew Moges , Melak Melkitu Fentie , Atenafu Azeb , Belew Aysheshim Kassahun 
Published: March 2022

Background: Hypertension is one of the leading causes of disability and death in both developed and developing countries including Ethiopia. Non-communicable diseases account for 42% of deaths in Ethiopia. However, it is still widely undetected and poorly controlled. Hence, this study aims to assess the lifestyle modification practices and related factors of adult hypertensive patients in the central Gondar region of northwestern Ethiopia. Methods: Institutional based, cross-sectional study was conducted from April 10 up to May 10, 2021. A simple random sampling was used to select 629 study participants. Data were collected by using self-administered and structured questionnaire. Data were entered to EpiData 4.6 and exported to SPSS 20 for further analysis. A multivariable logistic regression analysis was employed to identify the factors associated with lifestyle modification. Adjusted Odds Ratio (AOR) with 95% confidence interval was used to show the strength of association, while a P-value <.05 of was used to declare the significance of association. Results: The overall prevalence of recommended lifestyle modification in hypertensive patients was 24.2% (95% CI (20.8, 27.5)). Age ⩾65 years (AOR = 0.59, 95% CI: 0.39, 0.88), no formal education (AOR = 0.65, 95% CI: 0.4, 0.97), diagnosis time is 5 to 10 years (AOR = 1.93, 95% CI: 1.11, 3.34), co morbidities (AOR = 0.47, 95% CI: 0.3, 0.73), and rich wealth index (AOR = 1.99, 95% CI: 1.22, 3.27) are is significantly associated with good lifestyle modification practices. Conclusions: The practice of good lifestyle modifications in the study area was found to be low among the hypertensive patients. Respondents’ age, education status, wealth index, duration of diagnosis, and co morbidities were found to be significant factors related to good lifestyle modification practices. Therefore, more attention should be paid to providing nutrition counseling and health promotion to improve the practice of lifestyle modification in patients with hypertension.
Study on mechanical properties of seawater sea-sand coral aggregate concrete-filled BFRP tubular arches
Authors: Dong Zhiqiang , Liu Ziqing , Wu Gang , Zhu Hong , Lu Fei , Yan Zeyu , Shao XinXing 
Published: March 2022

In this paper, a novel arch-shaped BFRP tube with longitudinal BFRP bars pre-bonded on the inner wall is proposed and fabricated. It can provide strength in both circumferential and longitudinal directions and is suitable for the rapid construction of arch bridges in island environments by filling with seawater sea-sand coral aggregate concrete (SWCC) in situ. Ten SWCC-filled BFRP tubular arches were fabricated and tested under monotonic loading. Test variables include the wall thickness of the BFRP tube, the radius angles of the arch, and with or without pre-bonded BFRP bars. Test results showed that the failure modes of arches without BFRP bars were bending failure under the loading point. The ultimate bearing capacities were increased by 33.1% and 71.7% as the wall thickness increased from 2 mm to 3 mm and 4 mm, respectively. The failure modes of arches containing pre-bonded BFRP bars were bending-shear failure close to the loading plate. The ultimate bearing capacity of arches, which containing BFRP bars, with a wall thickness of 2 mm, 3 mm, and 4 mm increased by 215%, 248%, and 189%, respectively, compared with the specimens without BFRP bars. The integrity and ultimate bearing capacities of arches decreased with the increase of the radius angle and their failure modes exhibited obvious brittle damage characteristics. The proposed new type of arch has good prospects for application in the marine environment.
Investigating mean room surface exitance values for office lighting
Authors: Durante A , Kelly K 
Published: March 2022

Mean room surface exitance (MRSE) is a metric proposed to assess lighting quantity within a new design methodology focused on ambient and target illumination. This research builds upon findings from previous research examining the suitability of MRSE as a metric for assessing ambient illumination brightness levels and illumination adequacy for offices. An experiment was conducted to investigate a finding from previous studies that a linear relationship existed between perceived adequacy of illumination (PAI) and MRSE. It was found that the relationship diverges from linear once the scale of MRSE values is extended above the 100 lm/m2. This study also suggests a relationship between spatial brightness and MRSE for an extended range of MRSE values up to 1400 lm/m2. The findings from this research provide insight into a tentative range of MRSE levels that may be suitable for an office environment.
Return to School After Anterior Cruciate Ligament Reconstruction: A Prospective Study of Adolescents and Young Adults
Authors: Brutico Joseph M. , Paul Ryan W. , Wright Margaret L. , Cohen Steven B. , Ciccotti Michael G. , Dodson Christopher C. , Freedman Kevin B. , Hammoud Sommer 
Published: March 2022

Background: The ability to return to school after orthopaedic surgery is an important consideration for young patients, as there is substantial literature indicating that school attendance is correlated strongly with academic performance. Purpose: To evaluate the time to return to school, the barriers that students encounter when returning to school, and the academic effect of anterior cruciate ligament reconstruction (ACLR) in high school (HS) and college students. Study Design: Cohort study; Level of evidence, 2. Methods: Full-time HS and college/graduate school (C/GS) students who underwent ACLR during the 2017 to 2018 and 2018 to 2019 academic periods were included in the study. Patients were contacted 2 weeks postoperatively to complete a questionnaire that assessed their time to return to school and barriers that interfered with their ability to return, and they completed a second questionnaire at 6 weeks postoperatively that assessed academic performance and challenges faced upon returning to school. Results: Included were 36 (52.2%) full-time HS students and 33 (47.8%) full-time C/GS students. HS students reported a longer time to return to school compared with C/GS students (8.51 vs 5.89 days; P = .008). In addition, HS students missed more scheduled school days than C/GS students (5.39 vs 2.90 days; P < .001). The majority of HS (73.5%) and C/GS (65.5%) students cited pain as a barrier to return, and more than half of HS (70.6%) and C/GS (55.2%) students also cited restricted mobility as a barrier to return. HS students were more likely to miss an examination in the early postoperative period compared with their C/GS counterparts (65.7% vs 39.3%; P = .037). Many students in both cohorts received a grade less than expected in the early postoperative period; this was not significantly different between the 2 groups (HS, 50.0%; C/GS, 42.9%; P = .489). Conclusion: ACLR can have a negative effect on school attendance and academic performance among HS and C/GS students. Orthopaedic surgeons should counsel all students and their families adequately about the potential academic effect of orthopaedic surgery in order to maximize clinical results, academic performance, and satisfaction in their patients.
Sex-specific genetic modifiers identified susceptibility of cold stored red blood cells to osmotic hemolysis
Authors: Fang Fang , Hazegh Kelsey , Mast Alan E. , Triulzi Darrell J. , Spencer Bryan R. , Gladwin Mark T. , Busch Michael P. , Kanias Tamir , Page Grier P. 
Published: March 2022

Abstract
Background
Genetic variants have been found to influence red blood cell (RBC) susceptibility to hemolytic stress and affect transfusion outcomes and the severity of blood diseases. Males have a higher susceptibility to hemolysis than females, but little is known about the genetic mechanism contributing to the difference.

Results
To investigate the sex differences in RBC susceptibility to hemolysis, we conducted a sex-stratified genome-wide association study and a genome-wide gene-by-sex interaction scan in a multi-ethnic dataset with 12,231 blood donors who have in vitro osmotic hemolysis measurements during routine blood storage. The estimated SNP-based heritability for osmotic hemolysis was found to be significantly higher in males than in females (0.46 vs. 0.41). We identified SNPs associated with sex-specific susceptibility to osmotic hemolysis in five loci (SPTA1, KCNA6, SLC4A1, SUMO1P1, and PAX8) that impact RBC function and hemolysis.

Conclusion
Our study established a best practice to identify sex-specific genetic modifiers for sexually dimorphic traits in datasets with mixed ancestries, providing evidence of different genetic regulations of RBC susceptibility to hemolysis between sexes. These and other variants may help explain observed sex differences in the severity of hemolytic diseases, such as sickle cell and malaria, as well as the viability of red cell storage and recovery.
Integration of transcriptomic and proteomic analyses reveals several levels of metabolic regulation in the excess starch and early senescent leaf mutant lses1 in rice
Authors: Chen Zhiming , Wang Yongsheng , Huang Rongyu , Zhang Zesen , Huang Jinpeng , Yu Feng , Lin Yaohai , Guo Yuchun , Liang Kangjing , Zhou Yuanchang , Chen Fangyu 
Published: March 2022

Abstract
Background
The normal metabolism of transitory starch in leaves plays an important role in ensuring photosynthesis, delaying senescence and maintaining high yield in crops. OsCKI1 (casein kinase I1) plays crucial regulatory roles in multiple important physiological processes, including root development, hormonal signaling and low temperature-treatment adaptive growth in rice; however, its potential role in regulating temporary starch metabolism or premature leaf senescence remains unclear. To reveal the molecular regulatory mechanism of OsCKI1 in rice leaves, physiological, transcriptomic and proteomic analyses of leaves of osckI1 allele mutant lses1 (leaf starch excess and senescence 1) and its wild-type varieties (WT) were performed.

Results
Phenotypic identification and physiological measurements showed that the lses1 mutant exhibited starch excess in the leaves and an obvious leaf tip withering phenotype as well as high ROS and MDA contents, low chlorophyll content and protective enzyme activities compared to WT. The correlation analyses between protein and mRNA abundance are weak or limited. However, the changes of several important genes related to carbohydrate metabolism and apoptosis at the mRNA and protein levels were consistent. The protein-protein interaction (PPI) network might play accessory roles in promoting premature senescence of lses1 leaves. Comprehensive transcriptomic and proteomic analysis indicated that multiple key genes/proteins related to starch and sugar metabolism, apoptosis and ABA signaling exhibited significant differential expression. Abnormal increase in temporary starch was highly correlated with the expression of starch biosynthesis-related genes, which might be the main factor that causes premature leaf senescence and changes in multiple metabolic levels in leaves of lses1. In addition, four proteins associated with ABA accumulation and signaling, and three CKI potential target proteins related to starch biosynthesis were up-regulated in the lses1 mutant, suggesting that LSES1 may affect temporary starch accumulation and premature leaf senescence through phosphorylation crosstalk ABA signaling and starch anabolic pathways.

Conclusion
The current study established the high correlation between the changes in physiological characteristics and mRNA and protein expression profiles in lses1 leaves, and emphasized the positive effect of excessive starch on accelerating premature leaf senescence. The expression patterns of genes/proteins related to starch biosynthesis and ABA signaling were analyzed via transcriptomes and proteomes, which provided a novel direction and research basis for the subsequent exploration of the regulation mechanism of temporary starch and apoptosis via LSES1/OsCKI1 in rice.
Health care centre and emergency department utilization by patients with episodes of tachycardia
Authors: Nordblom Ann-Katrin , Boysen Gabriella Norberg , Berglund Mia , Kjellsdotter Anna 
Published: March 2022

Abstract
Background
Outpatients seek to visit health care facilities for episodes of tachycardia-related signs and symptoms. The challenge for physicians is to balance a proper initial assessment and avoid overlooking a possible arrhythmia. This common clinical situation affects individuals and health care utilization, and effective management may substantially affect health care resources. This study aimed to explore health care utilization for outpatients with episodes of tachycardia visiting health care centres (HCCs) and/or emergency departments (EDs).

Method
This retrospective study used data of adult outpatients (≥ 18 years) who were assessed by a physician as having a specific or nonspecific diagnosis of arrhythmia between 2017 and 2018, and data were retrieved from medical records and a regional registry database. Data was analysed with appropriate statistical analyses to identify disparities between sex, age and terms of search pattern for each health care facility. Analysis of variance was used to test disparities between the sexes, and one-factor ANOVA was used for the incidence of missed arrhythmias.

Results
A total of 2719 visits with 2373 outpatients were included in the study. The result showed a significant difference in the total number of visits (n = 2719) between female and male patients (68% vs. 32%, p < .001). In the 60–69- and 70–79-year age groups, females had significantly higher frequencies of visits than males (p = .018). A significant difference was also observed between sexes in terms of which health care facility they tended to visit (p < .001). Ninety-five percent of the outpatients visiting EDs were hospitalized. When estimating the incidence of missed arrhythmias (diagnoses) in relation to assessments, the results showed a 5% missed diagnosis involving potential atrioventricular nodal re-entry tachycardia and atrioventricular re-entry tachycardia. Moreover, the referral rate was low, especially from HCCs to cardiologists.

Conclusions
This study shows a significant difference in total visits in HCCs and/or EDs by patients of different sexes and indicates the need for improved care for outpatients with episodes of tachycardia. Sex- and age-related differences must be addressed with an aim of providing equal care. Finally, the low rate of referral from HCCs to cardiologists compared to the high proportion of hospitalizations from EDs, deserves further investigation.
Implementation of a text messaging intervention to patients on warfarin therapy in Brazilian primary care units: a quasi-experimental study
Authors: Souza-Silva Maira Viana Rego , Domingues Mara Luiza de Paiva , Chagas Victor Schulthais , Pereira Daniella Nunes , de Sá Laura Caetano , Almeida Mychelle Stefany Santos , Sales Thaís Lorenna Souza , Raposo Magda César , Guimarães Nathalia Sernizon , Oliveira João Antônio de Queiroz , Ribeiro Antonio Luiz Pinho , Cardoso Clareci Silva , Martins Maria Auxiliadora Parreiras , Enes Thais Bueno , Soares Thiago Barbabela de Castro , Baldoni André Oliveira , Marcolino Milena Soriano 
Published: March 2022

Abstract
Background
Warfarin remains the most affordable oral anticoagulant in many countries. However, it may have serious side effects, and the success of the therapy depends on the patient’s understanding of the medication and their adherence to treatment. The use of short messages services (SMS) is a strategy that can be used to educate patients, but there are no studies evaluating this intervention in patients taking warfarin. Therefore, we aimed to develop, implement, and assess the feasibility of an intervention using SMS to primary care patients taking warfarin in a medium-sized Brazilian city.

Methods
A bank of 79 SMS was drafted and validated by an expert panel. During 6 months, three times a week, patients received messages about anticoagulation with warfarin. At baseline and after 3 months, we assessed their knowledge and adherence with validated instruments. At the end of the follow-up, participants answered a satisfaction questionnaire. Subsequently, a scale-up phase was conducted, with another round of the intervention including 82 participants (29 from the first phase and 53 newly recruited). Seven months after the end of the scale-up, we asked the patients for their insights about the long-term effects of this program. All patients signed informed consent. The study was approved by the Research and Ethics committee of the Universidade Federal de Minas Gerais.

Results
In the pilot, 33 (89.2%) patients completed the follow-up. Among the participants who answered the satisfaction questionnaire (n = 29), 86.2% considered that the intervention motivated a healthy lifestyle and improved their understanding of warfarin therapy. All patients were willing to continue receiving the messages. Adherence measured by the Measure of Adherence to Treatment (MAT) test was high in the pre-intervention assessment and remained high (96.7% vs. 93.3%; p = 1.0000). The proportion of patients who achieved > 75% correct answers on the Oral Anticoagulation Knowledge (OAK) test increased from 6.5% to 25.6, p = 0.0703. In the scale-up, 23 patients answered the long-term assessment questionnaire. The main long-term knowledge reported was dietary information. Nine patients received the messages but did not remember their content.

Conclusion
The intervention was well-accepted and had a positive impact on patient’s knowledge about oral anticoagulation therapy. The scale-up assessment reinforced the need to constantly monitor digital interventions.