bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of innate immunity in the formation of various variants of the course of seasonal allergic rhinitis
Authors: Sizyakina L. P. , Andrreeva I. I. , Semenova N. I. , Kharitonova M. V. 
Published: April 2022

Purpose: to study the functional parameters of the innate immune response in various clinical courses of seasonal allergic rhinitis.Materials and methods: a comparative prospective study was conducted. 62 participants (patients with seasonal allergic rhinitis) were divided into subgroups with mild (34 people) and moderate (28 people). Th e parameters of the innate immune response were studied. Th e assessment was carried out during the exacerbation period, before the appointment of therapy and in remission, outside the palination season.Results: changes in the cells of the innate immune response in patients with seasonal allergic rhinitis are formed at the earliest stages of clinical manifestation, aff ect the functional potential of natural killer cells and the oxygen-producing activity of the neutrophilic link, and are stable outside the palination season. Increased production of proinfl ammatory and immunoregulatory mediators is a key manifestation of the progression of seasonal allergic rhinitis.Conclusion: inhibition of the functional resources of innate immunity cells and cytokine dysregulation can play a significant role in the development of complications of seasonal allergic rhinitis caused by secondary immune defi ciency.
Basophil activation test in the diagnosis of allergic reactions to local anesthetics
Authors: Chibisova O. N. , Lugovskaya G. I. , Khabarova O. V. 
Published: April 2022

Objective: to evaluate the detection of in vitro hypersensitivity to local anesthesia drugs by fl ow cytometry.Materials and methods: in the test of activation of basophils, the determination of the hypersensitivity reaction to local anesthetics of groups I, II (154 preparations) in 106 patients and T-lymphocytes of type 2 immune response (CD3 + CD294 +) was carried out by fl ow cytometry using the Allergenicity kit test system. In the history of the examined patients, there was a certain food and/ or drug intolerance.Results: Th e levels of sensitization to diff erent groups of local anesthetics were compared in the basophil activation test. Th e highest levels of hypersensitivity were observed to local anesthetics containing vasoconstrictors, stabilizers. In patients with hypersensitivity to drugs for local anesthesia, an increase in the number of T-lymphocytes of type 2 of the immune response was observed.Conclusions: based on the identifi ed hypersensitivity in the basophil activation test to local anesthesia drugs, the safest anesthetics were established. Th e diagnostic signifi cance of determining the level of T-lymphocytes of type 2 of the immune response in drug hypersensitivity is shown.
The Effects of the COVID-19 Pandemic on Mental Health Among Older Adults From Different Communities in Chengmai County, China: Cross-sectional Study
Authors: Xu Zhimin , Ghisi Gabriela Lima de Melo , Cui Lixian , Zeng Fang , Zhou Xiaohai , Yue Zhongtang , Chen Hanbei 
Published: April 2022

Background
Due to the strict measures employed to control the spread of SARS-CoV-2, the extent of COVID-19 goes beyond morbidity and mortality and affects individuals’ mental health in the long term.

Objective
This cross-sectional study aimed to investigate the effects of the COVID-19 pandemic on mental health and its contributing factors among older people in Chengmai County, China.

Methods
A web-based survey was administered through WeChat between March and April 2020. Older people (ie, >50 years) from local and foreign community groups completed the survey, which included items on sociodemographic and clinical characteristics, the 7-item Generalized Anxiety Disorder scale (GAD-7), and the 9-item Patient Health Questionnaire (PHQ-9). Independent t tests and a multiple linear regression analysis were used to investigate differences between anxiety and depression and the factors associated with these symptoms across the 2 groups.

Results
Overall, 469 responses were received; 119 responses (25.4%) were from male participants and 202 (43.1%) were from those older than 65 years. Of the 469 responses, 245 (52.2%) were from the local community group and 224 (47.8%) from the foreign group. The mean GAD-7 (P=.003) scores were significantly higher in the local group. Anxiety was significantly more present in the local group (61/245, 24.9% compared to 35/224, 15.6% in the foreign group; P=.01). A total of 6 respondents presented severe anxiety and 2 presented severe depression.

Conclusions
This study demonstrated that both community groups of older adults from the Chinese “Hometown of Longevity” presented anxiety or depressive disorders during the first months of the pandemic. Local community groups presented significantly more mental health disorders, which were associated with a history of previous psychological disorders.
PROSPECTIVE STUDY COMPARING CONCURRENT CHEMORADIATION WITH OR WITHOUT GEFITINIB IN TREATMENT OF LOCALLY ADVANCED HEAD AND NECK CARCINOMA
Authors: BANERJEE BISWARUP , DE SUMITAVA , BISWAS LINKON , MANDAL SRIKRISHNA 
Published: April 2022

ABSTRACT
BACKGROUND-Concurrent chemoradiotherapy (CTRT) is now an acceptable definitive therapy for locally advanced head and neck carcinomas. But, multiple studies revealed that addition of anti-EGFR agent with CTRT improves the loco-regional response at a cost of higher but acceptable toxicity. Our study aimed at assessing CTRT with or without Gefitinib in terms of treatment response and acute toxicity profile.
MATERIALS AND METHODS- Patients with Locally advanced, non-metastatic, squamous cell carcinoma of Head-neck were randomised in two groups-the control group received external beam radiotherapy 66Gy/33 fractions/6.5 weeks along with concurrent injection Cisplatin at the dose of 100mg/m2 on day 1, 22, and 43 during radiation and the study group received concurrent chemoradiotherapy along with Tab Gefitinib-250 mg during the duration of radiotherapy. Response assessment was done after completion of treatment and all patients were followed up for treatment related acute toxicity during the course of treatment and then at every month for at least 6 months.
RESULTS- 46.66% of study arm (CTRT+Gefitinib) patients showed complete response and Overall response was 79%. In control arm (CTRT alone), there was 51.6% complete response and Overall response was 77%, though difference was statistically not significant (p value 0.84). Although statistically not significant, Gefitinib containing arm had numerically higher hematological, gastro-intestinal toxicity and weight loss.
CONCLUSION- Gefitinib along with chemoradiation showed numerically higher overall response (complete response + partial response) and comparable acute toxicity profile in comparison to chemoradiation alone.
alfabetização na revista O Ensino-PR (1922-1924)
Authors: Zanlorenzi Claudia Maria Petchak , Nascimento Maria Isabel Moura 
Published: April 2022

A imprensa periódica educacional, no início do século XX, foi um recurso comumente utilizado, haja vista a precariedade da formação docente no Brasil. No Paraná, destaca-se a revista O Ensino, publicada entre os anos de 1922 a 1924, pela Inspetoria Geral do Ensino do Paraná. O presente estudo tem por objetivo analisar a referida revista, especificamente, investigando as temáticas sobre alfabetização. Verifica-se que a alfabetização, de forma pragmática, foi a pauta que frequentemente era registrada na revista em consonância com os demais debates, constituindo-se como solução para os problemas da educação. Outrossim, o estudo incita questões e debates, principalmente sobre a alfabetização e o quanto o tema é frequentemente abordado nas propostas de reformas governamentais desde o início do século XX e como a ênfase no fazer docente, sem uma formação teórica consistente, continua sendo a estratégia utilizada oficialmente.
transversalidade do discurso feminista em Anne With An E
Authors: Mariano Bertolino Luise , Souza Luciana , Guilherme Carrozza Newton 
Published: April 2022

Neste artigo, abordamos a questão feminista na série Anne With An E (2017) a partir da Análise de Discurso do artigo de jornal O que é justo? atribuído à personagem Anne Shirley. O objetivo é identificar quais as formações ideológicas que resultaram no processo discursivo de Anne e indicar os efeitos de sentido produzidos no discurso. Para atingir tal objetivo, nos baseamos nas teorias de Eni Orlandi para os procedimentos de Análise de Discurso para tecer as relações com o movimento feminista. O artigo visa contribuir nos estudos de Análise de Discurso entrelaçado à comunicação, ao refletir sobre as mudanças do papel da mulher na sociedade, a partir de formações discursivas e ideológicas desenvolvidas e veiculadas em um produto midiático.
Dinamika Restorative Justice Dalam Sistem Peradilan Pidana Di Indonesia
Authors: Wulandari Cahya 
Published: April 2022

Tujuan: menganalisis dan menjabarkan penerapan restorative justice di Indonesia khususnya terkait dalam proses penyelesaian perkara pidana. Penyelesaian perkara pidana melalui ADR berbasis restorative justice diharapkan dapat diatur secara lebih rinci dan tertata dalam KUHAP sebagai sumber hukum dalam beracara pidana di Indonesia. Metodologi: penelitian ini termasuk sebagai penelitian normative legal research dengan menggunakan pendekatan statute approach yang menelaah permasalahan yang akan dibahas menggunakan peraturan hukum berupa data sekunder (bahan hukum primer, sekunder dan tersier). Analisis dilakukan secara kualitatif dan pembahasan atas rumusan masalah menggunakan library research. Temuan: penyelesaian perkara pidana berbasis restorative justice di tingkat penyidikan dan penuntutan dapat mengurangi penumpukan perkara dan lebih mewujudkan keadilan sebagaimana diinginkan oleh para pihak (korban, pelaku dan lingkungan). Pemulihan para pihak yang berperkara ini berdasar pada Perkapolri Nomor 6 Tahun 2019 Tentang Penyidikan Tindak Pidana dan Perja Nomor 5 Tahun 2020 tentang Penghentian Penuntutan Berbasis Restorative Justice. Kegunaan: Pemerintah perlu membuat payung hukum yang komprehensif untuk mengatur proses penyelesaian perkara pidana melalui Alternative Dispute Resolution (ADR) berbasis restorative justice secara lebih rinci dan tertata dalam KUHAP di Indonesia. Kebaruan/Orisinalitas: Dasar hukum terbaru dalam proses penyelesaian perkara pidana berdasar pada restorative justice yang dikaitkan dengan Perkapolri Nomor 6 Tahun 2019 tentang Penyidikan Tindak Pidana dan Peraturan Kejaksaan RI Nomor 15 Tahun 2020 tentang Penghentian Penuntutan berdasarkan keadilan restorative. Berdasar pada ketentuan tersebut akan dibahas lebih lanjut terkait proses penyelesaian perkara pidana berbasis restorative justice di tingkat penyidikan dan penuntutan.
PERANCANGAN SISTEM INFORMASI PENGARSIPAN SURAT MASUK DAN KELUAR DI KANTOR KELURAHAN LEWA PAKU
Authors: Ina Aprilian , Hariadi Fajar 
Published: April 2022

Surat adalah salah satu jenis alat komunikasi yang paling penting digunakan oleh kantor Kelurahan Lewa Paku sebagai pemberi informasi. Di kantor Kecamatan Lewa Paku, proses pengarsipan surat masih manual. Proses ini memiliki kendala kesulitan pada proses pencarian surat, kehilangan surat serta proses penyimpanan yang besar. Sistem Informasi pengarsipan surat dibutuhkan untuk menyelesaikan permasalahan ini. Sistem informasi ini dibuat menggunakan PHP (Hypertext Preprocessor) dan merancang user interface menggunakan bootstrap. Pengambilan data lapangan menggunakan wawancara dan observasi. Pengembangan sistem informasi menggunakan model waterfall yang memiliki tahapan-tahapan dalam urutan yang sistematis mulai dari analisis sampai pengujian. Penelitian ini menghasilkan sebuah sistem informasi untuk membantu pengelolaan kegiatan surat menyurat. Pengujian sistem dilakukan dengan black-box dan SUS (System Usability Scale). Pengujian black-box menunjukkan semua fungsi aplikasi berhasil berfungsi dengan bak, sedangkan nilai SUS dari pengguna sistem di kelurahan memberikan nilai sebesar 61. Sehingga dapat diketahui bahwa sistem masih kurang efektif, efisien dan memuaskan pengguna.
RANCANG BANGUN PROTOTIPE KANDANG KAMBING SISTEM TERKOLEKSI DAN PEMBERIAN PAKAN OTOMATIS BERBASIS ARDUINO UNO R3
Authors: David Muhammad , Sulistiyanti Sri Ratna , Herlinawati Herlinawati , Fitriawan Helmy 
Published: April 2022

Peternak kambing saat ini kurang diminati dalam sektor peternakan, dikarenakan kotoran kambing yang berbau dan hanya menghasilan penghasilan tahunan. Oleh karena itu salah satun inovasi untuk mengatasi masalah ini dengan membuat Kandang kambing sistem terkoleksi dan pemberian pakan otomatis berbasis Arduino Uno R3 yang mampu mengumpulkan dan memisahkan feses dengan urine serta memberikan pakan otomatis secara real time sesuai waktu yang ditentukan. Pada pukul 08.00 dan 16.00 WIB pemberian pakan akan diberikan pada ternak dengan menggerakkan motor servo untuk membuka katup penampungan pakan sehingga pakan akan jatuh pada sensor loadcell dan ditimbang dengan berat minimal 1 kg agar konveyor dapat bergerak menghantarkan pakan pada ternak. Bersamaan dengan pemberian pakan, konveyor kotoran juga akan bergerak untuk menghantarkan kotoran menuju penampungan kotoran. Alat penelitian ini dapat menampilkan data nilai waktu pemberian pakan dengan keberhasilan sebesar 99,95%, berat pakan dengan tingkat keberhasilan 65,97%, waktu hidupnya relay sebagai switching dari motor DC selama 3,6 detik , dan jarak laju konveryer sejauh 60 cm. secera keseluruhan tingkat keberhasilan alat sebesar 91,48% dengan nilai rata rata waktu pengoperasian alat sebesar 12,6 detik. Sehingga dapat dikatakan secara fungsional alat telah berfungsi dengan baik.
Protecting Forested Areas in Non-Forest Zone through The Ecological Fiscal Transfer Scheme in Indonesia: A case study from Kutai Timur district
Authors: Nasir Mohamad 
Published: April 2022

Ecological fiscal transfer (EFT) is an incentive scheme of budgetary transfers from different levels of a government (central and regional) to reward performances in environmental management. In Indonesia, EFT is mainly intended to protect forest zones or protected areas but does not include forested areas in the non-forest zone. This article investigates the opportunities and challenges of adopting the EFT scheme as a policy instrument to maintain the forested areas in Kutai Timur, a district in East Kalimantan province with the largest forested areas in its non-forest zone. This study applies a socio-legal approach along with a regulatory simplification instrument to examine the laws and regulations surrounding the adoption of an EFT scheme in Kutai Timur district. It demonstrates that the Kutai Timur district government can adopt the EFT scheme, given that they have the authority to manage the APL and village funds allocation. The scheme has no specific requirements or standards, identifying priority issues in the environmental sector. To adopt the scheme, the district government should develop criteria and indicators by considering the goals and priorities of district development, the data availability, and the opportunity for every village to implement it. The preparation of these criteria and indicators must be carried out in a participatory and accountable process to be well accepted by the stakeholders. Further, the district government requires integrating the EFT scheme in district policies on village funds allocation. By implementing the EFT scheme, the district government can encourage village governments and villagers to protect and manage forested areas in their village.
Correlation between skin conductance measurements and subjective pain scales in children after otolaryngological procedures
Authors: Zieliński Jakub , Morawska-Kochman Monika , Dudek Krzysztof , Zatoński Tomasz 
Published: April 2022

Abstract

Introduction
Pain assessment in children is crucial in managing postoperative analgesia; it is therefore necessary to determine the most accurate tool for assessing pain in children. The aim of this study was to evaluate the correlation between skin conductance measurements and self-reporting pain scales in children after otolaryngology procedures.

Materials and methods
Thirty-three children (N=33) were assessed for eligibility for the research. Postoperative pain was assessed using the Visual Analogue Scale; the Wong-Baker Faces Pain Rating Scale; the Face, Legs, Activity, Cry, and Consolability scale; and a skin conductance algesimeter. The postoperative pain was measured 1 and 2 hours after the surgery.

Results
There was no statistically significant correlation between self-reported pain scores and the skin conductance fluctuations in the children studied, regardless of gender or age. A statistically significant correlation was found between the existing subjective pain scales in children.

Conclusions
The skin conductance measurements do not provide an additional reliable tool for assessing pain in patients after otolaryngological procedures. The existing self-reported pain scales are sufficient to assess postoperative pain in children.
The impact of Mindfulness and Mental Skills Protocols on Athletes’ Competitive Anxiety
Authors: Dana Amir , Shahir Vesal Alipour , Ghorbani Saeed 
Published: April 2022

Abstract

Study aim: This study aims at examining the impact of Mindfulness and mental skills on competitive anxiety in athletes.

Material and methods: The present study is quasi-experimental with a pretest-posttest design. Participants were 45 19–30 years old male shooters randomly assigned to three groups with 15 people. The test consisted of six 60-minute mindfulness training/Mental skills/control that lasted six weeks. Measurements included competitive state anxiety based on the competitive state anxiety inventory in two pretest and post-test stages. Data were analyzed using statistical software at a confidence level of 0.05 using the Statistical Package for the Social Sciences (SPSS).

Results: The results showed that cognitive interventions of Mindfulness and mental skills reduced competitive state anxiety (P < 0.05), but there was no difference between the effectiveness of these methods. (P < 0.05).

Conclusions: Six weeks of mindfulness and mental skills training can help improve athletic performance by reducing anxiety levels.
Sentiment Analysis of Customer Feedback in Online Food Ordering Services
Authors: Nguyen Bang , Nguyen Van-Ho , Ho Thanh 
Published: April 2022

Abstract

Background: E-commerce websites have been established expressly as useful online communication platforms, which is rather significant. Through them, users can easily perform online transactions such as shopping or ordering food and sharing their experiences or feedback.

Objectives: Customers’ views and sentiments are also analyzed by businesses to assess consumer behavior or a point of view on certain products or services.

Methods/Approach: This research proposes a method to extract customers’ opinions and analyse sentiment based on a collected dataset, including 236,867 online Vietnamese reviews published from 2011 to 2020 on foody.vn and diadiemanuong.com. Then, machine learning models were applied and assessed to choose the optimal model.

Results: The proposed approach has an accuracy of up to 91.5 percent, according to experimental study findings.

Conclusions: The research results can help enterprise managers and service providers get insight into customers’ satisfaction with their products or services and understand their feelings so that they can make adjustments and correct business decisions. It also helps food e-commerce managers ensure a better e-commerce service design and delivery.
Blended Learning and Student Satisfaction: The Moderating Effect of Student Performance
Authors: Zeqiri Jusuf , Kareva Veronika , Alija Sadri 
Published: April 2022

Abstract

Background: Blended learning is a new approach to teaching and learning created by combining traditional classroom learning with an online learning platform. In recent years, blended learning has become an increasingly popular form of e-learning. It is particularly suitable for transitioning from completely traditional forms of learning to online learning.

Objectives: This paper aims to examine the effect of blended learning on students’ performance and satisfaction and showcase whether students’ satisfaction with blended learning leads to performance improvement.

Methods/Approach: A quantitative research design has been utilized for data collection, consisting of a questionnaire administered to a sample of three hundred and nineteen (319) students from bachelor and master study programs at South East European University (SEEU) in N. Macedonia. Data gathered through this questionnaire have been analyzed through structural equation modelling (SEM).

Results: The results show that blended learning influences students’ performance and satisfaction.

Conclusions: Course management and interaction positively impact students’ satisfaction and performance. The interaction has a more significant effect on both satisfaction and performance outcomes from blended learning. The main conclusion is that blended learning contributes to students’ satisfaction which eventually leads to students’ improved performance.
The Partnership Network Structure of Automakers under Radical Technological Change
Authors: Isada Fumihiko 
Published: April 2022

Abstract

Background: Traditionally, dense network structures have dominated partnerships in the automotive industry. On the other hand, previous research in other industries has shown that network structures suitable for radical innovation include weak ties, structural holes and betweenness centrality.

Objective: The purpose of this research is to empirically analyse the effect of the ongoing and radical change in the business environment within the automotive industry, referred to as CASE (connected, autonomous/automated, shared, and electric), on the network structure of the partnerships of automobile manufacturers.

Methods/Approach: The methodology of this study is based on the use of real data on partnerships of car manufacturers around the world, analysed using social network analysis methods.

Results/Findings: The analysis confirms that there is a significant correlation between the degree of the CASE approach, the number of weak ties and the size of structural holes. In addition, several cases showed significant differences in the network structure between new technology ventures and existing legacy technology firms. The findings highlight the insight that the network structure of the automotive industry is likely to change significantly in the future due to technological innovation.
The Appropriate Work Environment for Older Employees: The Case of Slovenia
Authors: Rožman Maja , Čančer Vesna 
Published: April 2022

Abstract

Background: The increase in population life expectancy in developed economies is also reflected in the aging of the workforce; therefore, enterprises should create an appropriate work environment for all employees, emphasizing the older ones.

Objectives: The major objectives of this paper are to establish the impact of appropriate working conditions and training programs for older employees on their work motivation, as well as to establish the latter’s impact on the older employees’ work engagement in Slovenian medium-sized and large enterprises.

Methods/Approach: Structural equation modeling explored the links between four constructs – appropriate working conditions, training programs, work motivation, and work engagement.

Results: In Slovenian enterprises, appropriate working conditions and training programs for older employees positively impact their work motivation. Moreover, the work motivation of older employees positively impacts their work engagement.

Conclusions: These findings can be useful for employers or managers for developing targeted employee motivation and employee engagement programs to leverage the talents and dedication of older employees.