bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonwoven from cigarette butt applied in pre-treatment of surface water
Authors: Vielmo Ana Silvia De Lima , Rodrigues Ailton Borges , Rosa Eduardo Volkart da , Domingos Dayane Gonzaga , Schallemberger Juliana Barden , Nagel-Hassemer Maria Eliza 
Published: January 2022

This study aimed to evaluate a nonwoven (NW) production and performance from cellulose acetate fiber from cigarette butts andapplied to a filtration system for surface water pre-treatment. The system had a surface area of 528 cm2, cellulose acetate from cigarette butt as filter media, was used and was fed with surface water from a pond. In order to evaluate the treatment performance of the filtration system were evaluated in the raw water (RW) and the filtered water (FW) the classical parameter of water quality as turbidity, total suspended solids (TSS), apparent color, true color, and total organic carbon (TOC) and heavy metals (iron, copper, and cadmium). Moreover, the presence of nicotine was investigated in the FW. The results showed a mean removal efficiency in order to 62.01%, 54.42%, 50.36 %, 6.73%, and 5.20% for turbidity, TSS, apparent color, true color, and TOC, respectively. The removal of metals varied in the order of 72.26%, 9.61%, and 2.12% for cadmium, iron, and copper, respectively. The presence of nicotine in RW and FW was not identified. In this way, besides reducing the negative environmental impacts caused by cigarette butts present in the environment, the developed technology showed potential for removing pollutants present in surface waters.
Modal Decomposition Analysis of Combustion Instability Due to External Perturbation in a Mesoscale Burner Array
Authors: Choi Jeongan , Rajasegar Rajavasanth , Liu Qili , Lee Tonghun , Yoo Jihyung 
Published: January 2022

AbstractIn this work, the growth regime of combustion instability was studied by analyzing 10 kHz OH planar laser-induced fluorescence (PLIF) images through a combination of dynamic mode decomposition (DMD) and spectral proper orthogonal decomposition (SPOD) methods. Combustion instabilities were induced in a mesoscale burner array through an external speaker at an imposed perturbation frequency of 210 Hz. During the transient growth phase of combustion instability, 10 kHz OH PLIF imaging was employed to capture spatially and temporally resolved flame dynamics. Increased acoustic perturbations prevented flame reignition in the central recirculation zone and eventually led to the flame being extinguished inward from the outer burner array elements. Coherent modes and their growth rates were obtained from DMD spectral analyses of high-speed OH PLIF images. Positive growth rates were observed at the forcing frequency during the growth regime. Coherent structures, closely associated with thermoacoustic instability, were extracted using an appropriate SPOD filter operation to identify mode structures that correlate to physical phenomena such as shear layer instability and flame response to longitudinal acoustic forcing. Overall, a combination of DMD and SPOD was shown to be effective at analyzing the onset and propagation of combustion instabilities, particularly under transient burner operations.
A Temporal Study on Coach Behavior Profiles: Relationships With Athletes Coping and Affects Within Sport Competition
Authors: González-García Higinio , Martinent Guillaume , Nicolas Michel 
Published: January 2022

The study aimed to identify coach behavior profiles and explore whether athletes from distinct profiles significantly differed on coping and affects experienced within 2 hr before the competition and during the competition (measuring them 2 hr after the competition). A sample of 306 French athletes (Mage = 22.24; SD = 4.91; 194 men and 112 women) participated in the study. The results revealed the emergence of two profiles: (a) a coaching engaged profile that stands out for moderate physical training and planning, technical skills, mental preparation, goal setting, competition strategies, personal rapport, and moderate negative personal rapport; and (b) a less engaged coaching profile with low physical training and planning, technical skills, mental preparation, goal setting, competition strategies, personal rapport, and moderate negative personal rapport. Memberships of coach behavior profiles were not confounded by athletes’ practice experience, athlete’s gender, and coach experience. Results of latent profile analyses with Bose–Chaudhuri–Hocquenghem method (BCH) method revealed that coping and affective states significantly differed across the coach behavior profiles. As a whole, the less engaged coaching profile engenders the worst outcomes in competition. In conclusion, the detection of less adaptive coaching profiles would be crucial to prevent negative outcomes in athletes during the competition. This might be using intervention programs adapted to the peculiarities of athletes from a particular coach behavior profiles.
Effect of door-to-door distribution of HIV self-testing kits on HIV testing and antiretroviral therapy initiation: a cluster randomised trial in Malawi
Authors: Indravudh Pitchaya P , Fielding Katherine , Chilongosi Richard , Nzawa Rebecca , Neuman Melissa , Kumwenda Moses K , Nyirenda Rose , Johnson Cheryl C , Taegtmeyer Miriam , Desmond Nicola , Hatzold Karin , Corbett Elizabeth L 
Published: January 2022

IntroductionReaching high coverage of HIV testing remains essential for HIV diagnosis, treatment and prevention. We evaluated the effectiveness and safety of door-to-door distribution of HIV self-testing (HIVST) kits in rural Malawi.MethodsThis cluster randomised trial, conducted between September 2016 and January 2018, used restricted 1:1 randomisation to allocate 22 health facilities and their defined areas to door-to-door HIVST alongside the standard of care (SOC) or the SOC alone. The study population included residents (≥16 years). HIVST kits were provided door-to-door by community-based distribution agents (CBDAs) for at least 12 months. The primary outcome was recent HIV testing (in the last 12 months) measured through an endline survey. Secondary outcomes were lifetime HIV testing and cumulative 16-month antiretroviral therapy (ART) initiations, which were captured at health facilities. Social harms were reported through community reporting systems. Analysis compared cluster-level outcomes by arm.ResultsOverall, 203 CBDAs distributed 273 729 HIVST kits. The endline survey included 2582 participants in 11 HIVST clusters and 2908 participants in 11 SOC clusters. Recent testing was higher in the HIVST arm (68.5%, 1768/2582) than the SOC arm (48.9%, 1422/2908), with adjusted risk difference (RD) of 16.1% (95% CI 6.5% to 25.7%). Lifetime testing was also higher in the HIVST arm (86.9%, 2243/2582) compared with the SOC arm (78.5%, 2283/2908; adjusted RD 6.3%, 95% CI 2.3% to 10.3%). Differences were most pronounced for adolescents aged 16–19 years (adjusted RD 18.6%, 95% CI 7.3% to 29.9%) and men (adjusted RD 10.2%, 95% CI 3.1% to 17.2%). Cumulative incidence of ART initiation was 1187.2 and 909.0 per 100 000 population in the HIVST and SOC arms, respectively (adjusted RD 309.1, 95% CI −95.5 to 713.7). Self-reported HIVST use was 42.5% (1097/2582), with minimal social harms reported.ConclusionDoor-to-door HIVST increased recent and lifetime testing at population level and showed high safety, underscoring potential for HIVST to contribute to HIV elimination goals in priority settings.Trial registration numberNCT02718274.
Modelling costs of community-based HIV self-testing programmes in Southern Africa at scale: an econometric cost function analysis across five countries
Authors: d'Elbée Marc , Gomez Gabriela B , Sande Linda Alinafe , Mwenge Lawrence , Mangenah Collin , Johnson Cheryl , Medley Graham F , Neuman Melissa , Hatzold Karin , Corbett Elizabeth Lucy , Meyer-Rath Gesine , Terris-Prestholt Fern 
Published: January 2022

BackgroundFollowing success demonstrated with the HIV Self-Testing AfRica Initiative, HIV self-testing (HIVST) is being added to national HIV testing strategies in Southern Africa. An analysis of the costs of scaling up HIVST is needed to inform national plans, but there is a dearth of evidence on methods for forecasting costs at scale from pilot projects. Econometric cost functions (ECFs) apply statistical inference to predict costs; however, we often do not have the luxury of collecting large amounts of location-specific data. We fit an ECF to identify key drivers of costs, then use a simpler model to guide cost projections at scale.MethodsWe estimated the full economic costs of community-based HIVST distribution in 92 locales across Malawi, Zambia, Zimbabwe, South Africa and Lesotho between June 2016 and June 2019. We fitted a cost function with determinants related to scale, locales organisational and environmental characteristics, target populations, and per capita Growth Domestic Product (GDP). We used models differing in data intensity to predict costs at scale. We compared predicted estimates with scale-up costs in Lesotho observed over a 2-year period.ResultsThe scale of distribution, type of community-based intervention, percentage of kits distributed to men, distance from implementer’s warehouse and per capita GDP predicted average costs per HIVST kit distributed. Our model simplification approach showed that a parsimonious model could predict costs without losing accuracy. Overall, ECF showed a good predictive capacity, that is, forecast costs were close to observed costs. However, at larger scale, variations of programme efficiency over time (number of kits distributed per agent monthly) could potentially influence cost predictions.DiscussionOur empirical cost function can inform community-based HIVST scale-up in Southern African countries. Our findings suggest that a parsimonious ECF can be used to forecast costs at scale in the context of financial planning and budgeting.
Innovative demand creation strategies to increase voluntary medical male circumcision uptake: a pragmatic randomised controlled trial in Zimbabwe
Authors: Mavhu Webster , Neuman Melissa , Hatzold Karin , Buzuzi Stephen , Maringwa Galven , Chabata Sungai T , Mangenah Collin , Taruberekera Noah , Madidi Ngonidzashe , Munjoma Malvern , Ncube Getrude , Xaba Sinokuthemba , Mugurungi Owen , Johnson Cheryl C , Corbett Elizabeth L , Weiss Helen A , Fielding Katherine , Cowan Frances M 
Published: January 2022

IntroductionReaching men aged 20–35 years, the group at greatest risk of HIV, with voluntary medical male circumcision (VMMC) remains a challenge. We assessed the impact of two VMMC demand creation approaches targeting this age group in a randomised controlled trial (RCT).MethodsWe conducted a 2×2 factorial RCT comparing arms with and without two interventions: (1) standard demand creation augmented by human-centred design (HCD)-informed approach; (2) standard demand creation plus offer of HIV self-testing (HIVST). Interpersonal communication (IPC) agents were the unit of randomisation. We observed implementation of demand creation over 6 months (1 May to 31 October 2018), with number of men circumcised assessed over 7 months. The primary outcome was the number of men circumcised per IPC agent using the as-treated population of actual number of months each IPC agent worked. We conducted a mixed-methods process evaluation within the RCT.ResultsWe randomised 140 IPC agents, 35 in each arm. 132/140 (94.3%) attended study training and 105/132 (79.5%) reached at least one client during the trial period and were included in final analysis. There was no evidence that the HCD-informed intervention increased VMMC uptake versus no HCD-informed intervention (incident rate ratio (IRR) 0.87, 95% CI 0.38 to 2.02; p=0.75). Nor did offering men a HIVST kit at time of VMMC mobilisation (IRR 0.65, 95% CI 0.28 to 1.50; p=0.31). Among IPC agents that reported reaching at least one man with demand creation, both the HCD-informed intervention and HIVST were deemed useful. There were some challenges with trial implementation; <50% of IPC agents converted any men to VMMC, which undermined our ability to show an effect of demand creation and may reflect acceptability and feasibility of the interventions.ConclusionThis RCT did not show evidence of an effect of HCD-informed demand intervention or HIVST on VMMC uptake. Findings will inform future design and implementation of demand creation evaluations.Trial registration numberPACTR201804003064160.
Impact of health system strengthening on delivery strategies to improve child immunisation coverage and inequalities in rural Madagascar
Authors: Rajaonarifara Elinambinina , Bonds Matthew H , Miller Ann C , Ihantamalala Felana Angella , Cordier Laura , Razafinjato Benedicte , Rafenoarimalala Feno H , Finnegan Karen E , Rakotonanahary Rado J L , Cowley Giovanna , Ratsimbazafy Baolova , Razafimamonjy Florent , Randriamanambintsoa Marius , Raza-Fanomezanjanahary Estelle M , Randrianambinina Andriamihaja , Metcalf C Jessica , Roche Benjamin , Garchitorena Andres 
Published: January 2022

BackgroundTo reach global immunisation goals, national programmes need to balance routine immunisation at health facilities with vaccination campaigns and other outreach activities (eg, vaccination weeks), which boost coverage at particular times and help reduce geographical inequalities. However, where routine immunisation is weak, an over-reliance on vaccination campaigns may lead to heterogeneous coverage. Here, we assessed the impact of a health system strengthening (HSS) intervention on the relative contribution of routine immunisation and outreach activities to reach immunisation goals in rural Madagascar.MethodsWe obtained data from health centres in Ifanadiana district on the monthly number of recommended vaccines (BCG, measles, diphtheria, tetanus and pertussis (DTP) and polio) delivered to children, during 2014–2018. We also analysed data from a district-representative cohort carried out every 2 years in over 1500 households in 2014–2018. We compared changes inside and outside the HSS catchment in the delivery of recommended vaccines, population-level vaccination coverage, geographical and economic inequalities in coverage, and timeliness of vaccination. The impact of HSS was quantified via mixed-effects logistic regressions.ResultsThe HSS intervention was associated with a significant increase in immunisation rates (OR between 1.22 for measles and 1.49 for DTP), which diminished over time. Outreach activities were associated with a doubling in immunisation rates, but their effect was smaller in the HSS catchment. Analysis of cohort data revealed that HSS was associated with higher vaccination coverage (OR between 1.18 per year of HSS for measles and 1.43 for BCG), a reduction in economic inequality, and a higher proportion of timely vaccinations. Yet, the lower contribution of outreach activities in the HSS catchment was associated with persistent inequalities in geographical coverage, which prevented achieving international coverage targets.ConclusionInvestment in stronger primary care systems can improve vaccination coverage, reduce inequalities and improve the timeliness of vaccination via increases in routine immunisations.
Patient satisfaction following a switch from treat-and-extend to observe-and-plan regimen in age-related macular degeneration
Authors: Morken Tora Sund , Knutsen Christina , Hanssen Margrete Sætre , Austeng Dordi 
Published: January 2022

ObjectiveStandard treatment of neovascular age-related macular degeneration (nAMD) is intravitreal injections (IVI) of antivascular endothelial growth factor (anti-VEGF) according to treat-and-extend (TnE). Observe-and-plan (OnP), a new regimen based on each individual’s relapse interval lead to fewer clinical visits and has so far shown to be safe in treatment-naïve patients. In this study, we explore patient satisfaction and safety in nAMD when switching from TnE to OnP.Methods and analysis38 participants treated acording to TnE for ≥12 months were included and switched from TnE to OnP with their last stable interval. Main outcome was patient satisfaction (Leeds Satisfaction Questionnaire). Secondary outcomes were best-corrected visual acuity (BCVA), central retinal thickness (CRT) before and 12 months after switch and number of monitoring visits and injections of anti-VEGF 12 months prior to and following switch.ResultsMean patient satisfaction was higher (3.7±0.5 SD) at 12 months after switch from TnE to OnP than before (3.6±0.5 SD, p=0.009, response rate 76%). BCVA and CRT were unchanged. Number of monitoring visits and injections were lower in the 12 months following than prior to switch (p<0.001).ConclusionA switch from TnE to OnP in a non-treatment-naïve population resulted in higher patient satisfaction, while maintaining stable BCVA. This indicates that OnP may be applicable in the large group of nAMD patients that have received IVI for several years. OnP may alleviate the treatment burden on both individual and society of frequent clinical visits while increasing patient satisfaction.
Risk factors of flare in patients with systemic lupus erythematosus after glucocorticoids withdrawal. A systematic review and meta-analysis
Authors: Ji Lanlan , Xie Wenhui , Fasano Serena , Zhang Zhuoli 
Published: January 2022

ObjectiveGlucocorticoids (GC) withdrawal is part of the targets in current recommendations for SLE, but relapse is the most worrying issue. We aimed to investigate the predictors for flare in patients with SLE after GC withdrawal.MethodsWe systematically searched PubMed, EMBASE and Cochrane Library as well as Scopus databases up to 9 July 2021 for studies concerning predictive factors of relapses in patients with SLE after GC cessation. Pooled OR and 95% CI were combined using a random-effects or fixed-effects model.Results635 patients with SLE with GC discontinuation in 9 publications were eligible for the final analysis. Of them, 99.5% patients were in clinical remission before GC withdrawal. Serologically active yet clinically quiescent (SACQ) was associated with an increased risk of flare after GC withdrawal (OR 1.78, 95% CI (1.00 to 3.15)). Older age and concomitant use of hydroxychloroquine (HCQ) trended towards decreased risk of flare (weighted mean difference (WMD) −2.04, 95% CI (−4.15 to 0.06) for age and OR 0.50, 95% CI (0.23 to 1.07) for HCQ), yet not statistically significant. No significant association was observed regarding gender (pooled OR 1.75; 95% CI (0.59 to 5.20)), disease duration (WMD −11.91, 95% CI (−27.73 to 3.91)), remission duration (WMD −8.55, 95% CI (−33.33 to 16.23)), GC treatment duration (WMD −10.10, 95% CI (−64.09 to 43.88)), concomitant use of immunosuppressant (OR 0.86, 95% CI (0.48 to 1.53)).ConclusionYounger age and SACQ were potential risk factors of SLE flare among patients who discontinued GC. HCQ, but not immunosuppressant might prevent flare. GC withdrawal should be done with caution in this subgroup of patients.
Novel approach for pericapsular radiofrequency ablation of sacrococcygeal junction for patients with coccydynia
Authors: Feigin Guy , Wang Ning Nan , Di Grazia Vitaliano , Peng Philip 
Published: January 2022

IntroductionCoccydynia is a multifactorial complex clinical challenge. A multimodal approach with both conservative measures and procedural interventions is often recommended. We described a novel approach of radiofrequency (RF) ablation for the management of coccydynia.MethodsThree patients with known history of coccydynia refractory to conservative therapy were referred to our clinic. All received different types of RF ablation before: one with anterior bipolar lesion with no analgesia benefit, one with posterior stripped lesion with good benefit but only after 8 weeks of pain flare and one received anterior monopolar lesion with 50% pain reduction for 2–3 months. All subjects underwent a novel RF ablation to the anterior surface of the sacrococcygeal and intercoccygeal joints with two bipolar lesions using multi-tined needles under fluoroscopy guidance. One bipolar lesion was between two needles: one in the sacrococcygeal and another in the intercoccygeal (between first and second coccyx) joints. Another bipolar lesion was between needles on both side of the sacrococcygeal joint.ResultsAll experienced at least 65% pain relief for 6 months. The sitting endurance increased from less than 5 min to an average of 70 min. No adverse effect was observed in two and in the patient who used to have pain flare after lesioning, the pain flare lasted only for 2 weeks.DiscussionThe configuration of the two bipolar lesions with multi-tined needles in this case series stimulates the thinking of new approach for the ablation technique for pain from coccyx. Further prospective large case cohort study is needed.
Effect of long-term cropping systems on soil hydrophobicity of a clay loam soil under dryland conditions in southern Alberta
Authors: Miller J.J. , Owen M.L. , Ellert B.H. , Yang X.M. , Drury C.F. , Chanasyk D.S. 
Published: January 2022

The objective was to quantify the effect of crop rotations, crop type, life cycle, nitrogen fertilizer, manure application, and fallow on soil hydrophobicity (SH). The SH was measured for a long-term (16 yr) dryland field experiment on a Dark Brown clay loam soil in southern Alberta, Canada. Mean SH was significantly (P ≤ 0.05) greater in rotations with grass, perennial crops, manure application, and continuous cropping; whereas cereal–legume rotations and N fertilizer effects were undetectable. A strong, positive correlation occurred between SH and soil organic carbon concentration (r = 0.73). Soil water repellency should be measured on these plots using water-based methods.
NKG7 Is Required for Optimal Antitumor T-cell Immunity
Authors: Li Xian-Yang , Corvino Dillon , Nowlan Bianca , Aguilera Amelia Roman , Ng Susanna S. , Braun Matthias , Cillo Anthony R. , Bald Tobias , Smyth Mark J. , Engwerda Christian R. 
Published: January 2022

Abstract
Tumor antigen-specific CD8+ T cells play a critical role in antitumor immunity. Clinical trials reinvigorating the immune system via immune checkpoint blockade (ICB) have shown remarkable clinical promise. Numerous studies have identified an association between NKG7 expression and patient outcome across different malignancies. However, aside from these correlative observations, very little is known about NKG7 and its role in antitumor immunity. Herein, we utilized single-cell RNA sequencing (scRNA-seq) datasets, NKG7-deficient mice, NKG7-reporter mice, and mouse tumor models to investigate the role of NKG7 in neoantigen-mediated tumor rejection and ICB immunotherapy. scRNA-seq of tumors from patients with metastatic melanoma or head and neck squamous cell carcinoma revealed that NKG7 expression is highly associated with cytotoxicity and specifically expressed by CD8+ T cells and natural killer (NK) cells. Furthermore, we identified a key role for NKG7 in controlling intratumor T-cell accumulation and activation. NKG7 was upregulated on intratumor antigen-specific CD8+ T cells and NK cells and required for the accumulation of T cells in the tumor microenvironment. Accordingly, neoantigen-expressing mouse tumors grew faster in Nkg7-deficient mice. Strikingly, efficacy of single or combination ICB was significantly reduced in Nkg7-deficient mice.
See related article by Wen et al., p. 162