bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis of the diagnostic value of 18F-FDG PET/CT in the recurrence of epithelial ovarian cancer
Authors: Wang Xiaoyan , Yang Lifeng , Wang Yan 
Published: November 2022

BackgroundOvarian cancer is the leading cause of cancer-related death among gynecologic malignancies. With much evidence suggesting that 18F-FDG PET/CT may be an excellent imaging test for the diagnosis of epithelial ovarian cancer recurrence, we conducted a systematic review and meta-analysis to summarize relevant studies and evaluate the accuracy and application value of 18F-FDG PET/CT in the diagnosis of recurrence of epithelial ovarian cancer.Materials and methodsClinical trials of 18F-FDG PET/CT for the diagnosis of recurrence of epithelial ovarian cancer were systematically searched in PubMed, Embase, Cochrane Library, Web of Science and OVID database. The relevant literature was searched until May 22, 2022. Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) was used to evaluate the quality of the included original studies, and the meta-analysis was performed using a bivariate mixed-effects model and completed in Stata 15.0.ResultsA total of 17 studies on 18F-FDG PET/CT for the diagnosis of epithelial ovarian cancer recurrence were included in this systematic review, involving 639 patients with epithelial ovarian cancer. Meta-analysis showed that the sensitivity, specificity and area under the curve of 18F-FDG PET/CT for the diagnosis of epithelial ovarian cancer recurrence were 0.88 (95% CI: 0.79 - 0.93), 0.89 (95% CI: 0.72 - 0.96) and 0.94 (95% CI: 0.91- 0.96), respectively. Subgroup analysis showed higher diagnostic efficacy in prospective studies than in retrospective studies, and no significant publication bias was observed in Deeks’ funnel plot, with sensitivity analysis revealing the stability of results. Meta regression shows that the heterogeneity of this study comes from study type.Conclusion18F-FDG PET/CT has good diagnostic value in the recurrence of epithelial ovarian cancer.
Clinicopathologic features, prognostic factors, and outcomes of visceral sarcomas: A retrospective 12-year single-center study
Authors: Yang Songwei , Liao Zhichao , Li Ting , Liu Haotian , Ren Zhiwu , Wu Haixiao , Zhao Jun , Teng Sheng , Xing Ruwei , Yang Yun , Yang Jilong 
Published: November 2022

BackgroundVisceral sarcomas are a rare form of soft tissue sarcoma. This study aimed to evaluate the survival and prognostic factors and effective treatments for visceral sarcomas.MethodsAll patients with visceral sarcoma referred to our center between January 2010 and December 2021 were retrospectively analyzed. The Kaplan-Meier method and a log-rank test were used for survival analysis.ResultsA total of 53 patients with visceral sarcoma were analyzed in this study with the median age at diagnosis of 57 (range, 24-77) years. Among them, 37 (69.8%) and 16 (30.2%) patients had localized and metastatic diseases at the initial presentation, respectively, and 44 patients underwent surgical resection. The median follow-up, event-free survival (EFS) and overall survival (OS) were 63.0 (range, 2-130), 42.0 months (95% confidence interval [CI] 10.879-73.121) and 45.0 months (95% CI 9.938-80.062), respectively. The 5-year EFS and OS rates were 44% and 46%, respectively. Univariate analysis of prognostic indicators illustrated that metastasis at presentation, surgery, surgical margin and the types of surgery were significantly associated with OS and EFS. In this study, combined chemotherapy or radiotherapy had no effects on EFS and OS.ConclusionPrimary visceral sarcoma is an uncommon and aggressive malignant tumor with a higher rate of local recurrence. In the largest cohort of visceral sarcomas in China to date, we identified metastases at presentation, surgery, surgical margin, and the types of surgery as independent predictors of survival. The combination of chemotherapy and radiotherapy did not affect survival.
Treatment plan prescreening for patient-specific quality assurance measurements using independent Monte Carlo dose calculations
Authors: Xu Yuan , Zhang Ke , Liu Zhiqiang , Liang Bin , Ma Xiangyu , Ren Wenting , Men Kuo , Dai Jianrong 
Published: November 2022

PurposeThis study proposes a method to identify plans that failed patient-specific quality assurance (QA) and attempts to establish a criterion to prescreen treatment plans for patient-specific QA measurements with independent Monte Carlo dose calculations.Materials and methodsPatient-specific QA results measured with an ArcCHECK diode array of 207 patients (head and neck: 25; thorax: 61; abdomen: 121) were retrospectively analyzed. All patients were treated with the volumetric modulated arc therapy (VMAT) technique and plans were optimized with a Pinnacle v16.2 treatment planning system using an analytical algorithm-based dose engine. Afterwards, phantom verification plans were designed and recalculated by an independent GPU-accelerated Monte Carlo (MC) dose engine, ArcherQA. Moreover, sensitivity and specificity analyzes of gamma passing rates between measurements and MC calculations were carried out to show the ability of MC to monitor failing plans (ArcCHECK 3%/3 mm,&lt;90%), and attempt to determine the appropriate threshold and gamma passing rate criterion utilized by ArcherQA to prescreen treatment plans for ArcCHECK measurements. The receiver operator characteristic (ROC) curve was also utilized to characterize the performance of different gamma passing rate criterion used by ArcherQA.ResultsThe thresholds for 100% sensitivity to detect plans that failed patient-specific QA by independent calculation were 97.0%, 95.4%, and 91.0% for criterion 3%/3 mm, 3%/2 mm, and 2%/2 mm, respectively, which corresponded to specificities of 0.720, 0.528, and 0.585, respectively. It was shown that the 3%/3 mm criterion with 97% threshold for ArcherQA demonstrated perfect sensitivity and the highest specificity compared with other criteria, which may be suitable for prescreening treatment plans treated with the investigated machine to implement measurement-based patient-specific QA of patient plans. In addition, the area under the curve (AUC) calculated from ROC analysis for criterion 3%/3 mm, 3%/2 mm, and 2%/2 mm used by ArcherQA were 0.948, 0.924, and 0.929, respectively.ConclusionsIndependent dose calculation with the MC-based program ArcherQA has potential as a prescreen treatment for measurement-based patient-specific QA. AUC values (&gt;0.9) showed excellent classification accuracy for monitoring failing plans with independent MC calculations.
Nomogram for prediction of peritoneal metastasis risk in colorectal cancer
Authors: Song Xian-qing , Liu Zhi-xian , Kong Qing-yuan , He Zhen-hua , Zhang Sen 
Published: November 2022

ObjectivePeritoneal metastasis is difficult to diagnose using traditional imaging techniques. The main aim of the current study was to develop and validate a nomogram for effectively predicting the risk of peritoneal metastasis in colorectal cancer (PMCC).MethodsA retrospective case-control study was conducted using clinical data from 1284 patients with colorectal cancer who underwent surgery at the First Affiliated Hospital of Guangxi Medical University from January 2010 to December 2015. Least absolute shrinkage and selection operator (LASSO) regression was applied to optimize feature selection of the PMCC risk prediction model and multivariate logistic regression analysis conducted to determine independent risk factors. Using the combined features selected in the LASSO regression model, we constructed a nomogram model and evaluated its predictive value via receiver operating characteristic (ROC) curve analysis. The bootstrap method was employed for repeated sampling for internal verification and the discrimination ability of the prediction models evaluated based on the C-index. The consistency between the predicted and actual results was assessed with the aid of calibration curves.ResultsOverall, 96 cases of PMCC were confirmed via postoperative pathological diagnosis. Logistic regression analysis showed that age, tumor location, perimeter ratio, tumor size, pathological type, tumor invasion depth, CEA level, and gross tumor type were independent risk factors for PMCC. A nomogram composed of these eight factors was subsequently constructed. The calibration curve revealed good consistency between the predicted and actual probability, with a C-index of 0.882. The area under the curve (AUC) of the nomogram prediction model was 0.882 and its 95% confidence interval (CI) was 0.845–0.919. Internal validation yielded a C-index of 0.868.ConclusionWe have successfully constructed a highly sensitive nomogram that should facilitate early diagnosis of PMCC, providing a robust platform for further optimization of clinical management strategies.
Pan-cancer analysis of trophinin-associated protein with potential implications in clinical significance, prognosis, and tumor microenvironment in human cancers
Authors: Li Zhenfen , Pu Zhangya , Yang Ziyue , Zhu Yuanyuan , Deng Ying , Li Ning , Peng Fang 
Published: November 2022

BackgroundTrophinin-associated protein (TROAP), a cytoplasmic protein, is essential for microtubule cytoskeleton assembly. Mounting evidence demonstrates the vital role of TROAP in regulating the proliferation and migration of cells, but it is unclear how it contributes to cancer progression.MethodsThe online portals of GEPIA2, Cancer Cell Line Encyclopedia, UALCAN, Human Protein Atlas, and PrognoScan were used to analyze TROAP expression in various tumors and further evaluate its correlation with prognosis. With Western blot and quantitative real-time PCR analysis, we validated TROAP expression levels in hepatocellular carcinoma (HCC) and colorectal cancer (CRC). Ten pairs of HCC and CRC tissues were selected for immunohistochemistry to determine TROAP expression levels in tumors and adjacent tissues, respectively. TROAP knockdown in CRC and HCC cells to verify its role in malignant phenotypes. The genomic and post-transcriptional alterations of TROAP in tumors were determined using the cBioPortal and SangerBox databases. Also, TISIDB was used to investigate the relationship between TROAP expression and tumor microenvironment(TME) among different cancer types. Moreover, a correlation was found between the expression of TROAP and drug sensitivity using GSCALite and CellMiner databases.ResultsTROAP expression was significantly upregulated in most cancer types, which is consistent with our validated experimental results in HCC and CRC cells, and immunohistochemistry results. And a poor prognosis was linked to TROAP aberrant expression. Our findings indicated that malignant phenotypes and tumorigenesis induced by TROAP could be due to an activation of the PI3K/Akt/GSK-3β signaling pathway. Furthermore, we found a correlation between TROAP expression and genomic and post-transcriptional alterations in various tumors, including tumor mutation burden, and microsatellite instability. Next, we demonstrated that TROAP expression was associated with the infiltration of immune cells, such as neutrophils and macrophages, and correlated with immunomodulation-related genes in the TME. Additionally, the potential role of TROAP expression in predicting the sensitivity of drugs, including melphalan and chlorambucil, was demonstrated.ConclusionsCollectively, these findings indicated a significant correlation between TROAP expression and malignant phenotype, functional mechanism, survival possibility, TME, therapeutic potential, and prediction of drug sensitivity in various cancers. Hence, TROAP is a promising biomarker and therapeutic target for predicting cancer outcomes.
The prognostic impact of BMI on colorectal cancer is stratified by tumor location
Authors: Zhang Zixi , Yan Xueli , Lu Yan , Guo Xiaowen , Jiao Min , Wang Weizhong , Sun Boqian , Zhou Yi , Hu Qinglin , Chu Dake 
Published: November 2022

PurposeRecent studies have revealed the contrasting prognostic roles of body mass index (BMI) and tumor location in colorectal cancer (CRC). Given that right- and left-sided CRC may exhibit inverse effects on outcome and body weight, the present study aimed to examine whether the prognostic value of BMI and tumor location could be reciprocally stratified.MethodsThis prospective, observational study recruited 4,086 patients diagnosed with stage III CRC from five independent clinical centers in China. The association of patients’ outcomes with BMI and tumor location was evaluated hierarchically by Kaplan–Meier and Cox proportional-hazards models.ResultsAlthough BMI was not associated with overall outcome, the association was significantly modified by tumor location. Among left-sided tumors, obesity and overweight were significantly associated with adverse overall survival (OS) and disease-specific survival (DSS). In contrast, among right-sided tumors, overweight was significantly associated with more favorable OS and DSS compared with the normal-weight group. The association of survival with tumor location did not reach statistical significance. However, hierarchical analysis by BMI revealed that left-sided tumors were associated with more favorable outcomes in the normal-weight group, while there was no statistically significant difference in the overweight or obese group.ConclusionsBMI and tumor location may have opposing effects on CRC prognosis, when stratified by each other, after adjusting for other known prognostic factors. These findings are the first to show the interactive prognostic impact of BMI and tumor location, which could be relevant to the stratification of patient management.
Optimizing antidotal treatment with the oral HSP90 inhibitor TAS-116 against hydrochloric acid-induced pulmonary fibrosis in mice
Authors: Solopov Pavel A. , Colunga Biancatelli Ruben Manuel Luciano , Dimitropolou Christiana , Day Tierney , Catravas John D. 
Published: November 2022

Exposure to high concentrations of hydrochloric acid (HCl) can lead to severe acute and chronic lung injury. In the aftermath of accidental spills, victims may be treated for the acute symptoms, but the chronic injury is often overlooked. We have developed a mouse model of acute and chronic lung injury, in which the peak of acute lung injury occurs on the day 4 after HCl exposure. We have also demonstrated that HSP90 inhibitors are effective antidotes when administered starting 24 h after HCl. In this study we examined the hypothesis that the novel oral HSP90 inhibitor TAS-116 can effectively ameliorate HCl-induced lung injury even when treatment starts at the peak of the acute injury, as late as 96 h after HCl. C57BI/6J mice were intratracheally instilled with 0.1N HCl. After 24 or 96 h, TAS-116 treatment began (3.5, 7 or 14 mg/kg, 5 times per week, p. o.) for either 2,3 or 4 or weeks. TAS-116 moderated the HCl-induced alveolar inflammation, as reflected in the reduction of white blood cells and total protein content in bronchoalveolar lavage fluid (BALF), overexpression of NLRP3 inflammasome, and inhibited the activation of pro-fibrotic pathways. Furthermore, TAS-116 normalized lung mechanics and decreased the deposition of extracellular matrix proteins in the lungs of mice exposed to HCl. Delayed and shortened treatment with TAS-116, successfully blocked the adverse chronic effects associated with acute exposure to HCl.
Monocyte to high-density lipoprotein and apolipoprotein A1 ratios are associated with bone homeostasis imbalance caused by chronic inflammation in postmenopausal women with type 2 diabetes mellitus
Authors: Huang Rong , Chen Yang , Tu Mei , Wang Wei 
Published: November 2022

Objective: Emerging evidences demonstrated that chronic inflammation can influence bone metabolism in type 2 diabetes mellitus (T2DM), leading to bone homeostasis imbalance. The aim of this study was to assess the correlations between novel pro-inflammatory indexes like monocyte to high-density lipoprotein (MHR), apolipoprotein A1 (MAR) ratios and bone mineral density (BMD), bone turnover markers in Chinese postmenopausal women with T2DM.Method: In this study, a total of 619 participants with complete data were included in the final analysis. Demographic and anthropometric information was collected. Biochemical parameters and bone turnover markers were determined by standard methods. BMD was measured by dual-energy x-ray absorptiometry. Correlation analysis and regression models were conducted to assess the associations between MHR, MAR and bone turnover markers, BMD. Multiple binomial logistic regression model was used to estimate the independent variables of MHR and MAR for osteoporosis.Results: Overall, the prevalence of osteoporosis was 38.3%. MHR and MAR were significantly correlated with C-terminal cross linking of type I collagen (β-CTX), L1-L4, femoral neck BMD and T scores. These correlations remained significant after adjustment for other confounding factors. Meanwhile, MHR and MAR were also significantly associated with higher odds of osteoporosis, the odds ratios (ORs) (95%CI) were 1.88 (1.49–2.38) and 2.30 (1.72–3.09) respectively. Furthermore, MHR and MAR seemed to have a good identifying value for osteoporosis. The area under the curve of MHR and MAR identifying osteoporosis were 0.791 (95% CI: 0.753–0.828) and 0.843 (95% CI: 0.809–0.877) respectively (p &lt; 0.001). The optimal cut-off values of MHR and MAR were 4.53 × 108/mmol (sensitivity: 60.8%, specificity: 85.9%) and 4.74 × 108/g (sensitivity: 71.7%, specificity: 89.3%) respectively.Conclusion: MHR and MAR were significantly associated with osteoporosis. These two novel pro-inflammatory indexes may be ideal markers to reflect bone homeostasis imbalance caused by chronic inflammation in Chinese postmenopausal women with T2DM.
Serious adverse reaction associated with the COVID-19 vaccines of BNT162b2, Ad26.COV2.S, and mRNA-1273: Gaining insight through the VAERS
Authors: Yan Ming-Ming , Zhao Hui , Li Zi-Ran , Chow Jun-Wei , Zhang Qian , Qi Yu-Peng , Wu Shu-Shan , Zhong Ming-Kang , Qiu Xiao-Yan 
Published: November 2022

Background and purpose: Serious adverse events following immunization (AEFI) associated with the COVID-19 vaccines, including BNT162b2 (Pfizer-BioNTech), Ad26.COV2.S (Janssen), and mRNA-1273 (Moderna), have not yet been fully investigated. This study was designed to evaluate the serious AEFI associated with these three vaccines.Methods: A disproportionality study was performed to analyze data acquired from the Vaccine Adverse Event-Reporting System (VAERS) between 1 January 2010 and 30 April 2021. The reporting odds ratio (ROR) method was used to identify the association between the COVID-19 vaccines BNT162b2, Ad26.COV2.S, and mRNA-1273 and each adverse event reported. Moreover, the ratio of the ROR value to the 95% CI span was applied to improve the credibility of the ROR. The median values of time from vaccination to onset (TTO) for the three vaccines were analyzed.Results: Compared with BNT162b2 and mRNA-1273, Ad26.COV2.S vaccination was associated with a lower death frequency (p &lt; 0.05). Ad26.COV2.S vaccination was associated with a lower birth defect and emergency room visit frequency than BNT162b2 (p &lt; 0.05). There were 6,605, 830, and 2,292 vaccine recipients who suffered from COVID-19-related symptoms after vaccination with BNT162b2, Ad26.COV2.S, and mRNA-1273, respectively, including people who were infected by COVID-19, demonstrated a positive SARS-CoV-2 test, and were asymptomatic. Serious AEFI, including thromboembolism, hemorrhage, thrombocytopenia, cardiac arrhythmia, hypertension, and hepatotoxicity, were associated with all three vaccines. Cardiac failure and acute renal impairment events were associated with BNT162b2 and mRNA-1273, while seizure events were associated with BNT162b2 and Ad26.COV2.S. The median values of TTO associated with the three vaccinations were similar.Conclusion: These findings may be useful for health workers and the general public prior to inoculation, especially for patients with underlying diseases; however, the risk/benefit profile of these vaccines remains unchanged. The exact mechanism of SARS-CoV-2 vaccine-induced AEFI remains unknown, and further studies are required to explore these phenomena.
The numerical investigations of SiGe/Si heterojunction electro-optic modulator in mid-infrared
Authors: Feng Song , Hu Xiangjian , Feng Lulu , Wang Di , Chen Menglin , Liu Yong , Hu Heming , Jia Lianxi 
Published: November 2022

We present the detailed numerical analysis and characterization of SiGe/Si heterojunction electro-optic modulator at 2 μm, 4.3 μm, and 5 μm wavelengths. We investigate the band, the refractive index, and the carrier injection efficiency of SiGe/Si heterojunction PIN electrical structure. Numerical investigations are carried out on the key geometrical parameters, doping concentration, Ge content. The results show that the modulated voltage of SiGe/Si PIN heterojunction modulator is lower 50% than that of Si modulator under the same modulation effect. In order to eliminate the absorption losses of SiO2 in mid-infrared, the punch Mach–Zehnder optical structure is established and researched. The research present that the modulator has the short 500 µm phase shifters and the low VπLπ of 0.042 Vcm under forward bias voltage, and the extinction ratio is greater than 12.81 dB. The high-speed transmission characteristics are shown to have clean eye diagrams up to 40 Gbps in mid-infrared.
Interference fringe suppression in tunable diode laser absorption spectroscopy based on CEEMDAN-WTD
Authors: Wang Shoulin , Gong Weihua , Wang Zhaowei , Wei Yubin , Li Yanfang , Zhang Tingting , Zhang Qinduan , Zhang Lin , Song Fugang , Zhang Wei , Liu Tongyu 
Published: November 2022

Owing to interference fringes in the multireflective gas cell, the detection sensitivity of a system in tunable diode laser absorption spectroscopy (TDLAS) will decrease significantly. In this work, a combined scheme of complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) and wavelet threshold denoising (WTD) is proposed. Theoretical simulations were performed to validate the effects of the proposed algorithm, which was also verified via a CO2 detection experiment. After CEEMDAN-WTD processing, the noisy intrinsic mode function (IMF), pure IMF, and residual components of the detection signal were identified and reconstructed successfully. Based on analysis of the simulations, CEEMDAN-WTD algorithm improved the signal-to-noise ratio by 1.87 times and decreased the root mean-squared error by 37.6% than the moving average algorithm. For the CO2 detection system, R2 = 0.999 was determined by the calibration experiment. Additionally, based on Allan variance analysis and a long-time experiment, the limit of detection was estimated to be 3.08 ppm for an average time of 148 s and measurement accuracy of 0.65%, respectively. The obtained results sufficiently validate that the CEEMDAN-WTD algorithm can effectively suppress interference fringe noise in TDLAS.
Photoelectron momentum distribution of hydrogen atoms in a superintense ultrashort high-frequency pulse
Authors: Wang Jun , Li Gen-Liang , Liu Xiaoyu , Zhu Feng-Zheng , Jiao Li-Guang , Liu Aihua 
Published: November 2022

We use a numerically solved time-dependent Schrödinger equation for calculating the photoelectron momentum distribution of ground-state hydrogen atoms in the presence of superintense ultrashort high-frequency pulses. It is demonstrated that the dynamic interference effect within a superintense XUV laser beam has the ability to significantly alter the photoelectron momentum distribution. In our work, a clearly visible dynamic interference pattern is observed when hydrogen atoms are exposed to a superintense circularly polarized laser pulse with a photon energy of ℏω = 53.605 eV, which has previously been found for linearly polarized pulses or the weakly bounded model H− system for circularly polarized pulses. Angular-distorted interference arises for linear superintense XUV pulses of similar intensity. The significant differences in photoelectron momentum distributions that have been seen by linearly and circularly polarized XUV pulses are caused by the Coulomb rescattering phenomenon.