bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends In Hepatitis B, Influenza, And Pneumococcal Vaccination In Diabetic Patients
Authors: Alzahrani Ziyad , Bashrahil Bader , Alzahrani Muhanad Saleh , Alghamdi Nawaf , Nooh Mohammad , Alsolami Hatem , Alghamdi Abdullah Fuad , Alabbasi Abdullah Ahmed , Khan Muhammad Anwar , Alzahrani Abdullah M 
Published: March 2022

Abstract
Background: Diabetes is one of the most prevalent diseases in Saudi Arabia to the extent that the country is ranked 4th in terms of incidence rate. Diabetes poses multiple health threats not only to patients but also to society and the healthcare system. Thus, numerous measures have been adapted to contain diabetes risk. One of these is the recommendation of vaccination sets for diabetic patients.Aim: This study aims to measure the coverage of hepatitis B virus (HBV), influenza, and pneumococcal vaccines in diabetic patients.Methods: Using a retrospective chart review, data were collected from 385 diabetic patients. An approved data collection sheet was used. Phone calls were utilized for subjective-based questions. The sample size was calculated via Raosoft@. Descriptive or inferential statistical analysis was performed using SPSS.Results: Type 1 and type 2 diabetic patients represented 44.2% and 55.8%, respectively. Only 15.2% of patients received influenza vaccination in the last 12 months. Approximately 14.2% of diabetic patients received the pneumococcal vaccine, while the HBV vaccination rate was 12.9%. Hospital admission within the last 12 months of influenza-vaccinated patients was 22.8%, while the unvaccinated patients recorded 77.8%. Diabetic patients reported that physicians’ recommendation rates of vaccines were 25.8% for influenza vaccine, 15.5% for pneumococcal vaccine, and 10.8% for HBV vaccine.Conclusions: Measuring vaccination rates of 12.9%, 14.2% and 15.2%, respectively, concludes that compliance with the medical recommendations of vaccinating diabetic patients is suboptimal. Healthcare institutions must collaborate with primary care physicians to integrate more efficient and adherent vaccination programs.
Evaluation of the Blood and Serum Biomarkers for the Prognosis and Progression of the ALS Disease by Eliminating the Effects of Aging
Authors: Aydemir Duygu , surucu Selcuk , Basak Ayse Nazli , Ulusu Nuriye Nuray 
Published: March 2022

Abstract
Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease. There are no pathognomonic tests for ALS prognosis; clinical diagnosis of the disease takes time and is usually difficult. Prognostic biomarkers are urgently needed for rapid and effective ALS prognosis. Male albino rats were divided into ten groups based on age as 0 (40–45 days old), A (70–75 days old), B (90–95 days old), C (110–115 days old), and D (130–135 days old). Each group is divided into two subgroups according to their mutation status as wild type (SOD1WT) and mutated (SOD1G93A). Serum and blood biomarkers were measured of 90 rats to evaluate possible biomarkers for ALS prognosis. Weight loss, cholesterol, creatinine, Alkaline phosphatase (ALKP), glucose, total bilirubin (TBIL), blood urine nitrogen (BUN), c-peptide, glucagon, PYY, MCP-1, white blood cell (WBC), lymphocyte (LYM), monocyte (MID), granulocyte (GRAN), red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width with standard deviation (RDW-SD), red cell distribution width with the coefficient of variation (RDW-CV), platelet (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and procalcitonin (PCT) levels were changed in the SOD1G93A rats compared to the SOD1WT rats. First time in the literature, we showed promising blood and serum biomarkers in the pre-symptomatic and symptomatic stages of ALS by eliminating the effects of aging that can be used for early diagnosis of ALS.
Meeting in the Middle: Pediatric Abdominal Wall Reconstruction for Omphalocele
Authors: Kondra Katelyn , Jimenez Christian , Stanton Eloise , Chen Kevin , Shin Cathy E. , Hammoudeh Jeffrey A. 
Published: March 2022

Abstract
PurposeOmphalocele is a congenital abdominal wall defect with an incidence of 1/4,200 births. Repair timing varies from the neonatal period to the first few years of life. Surgical technique has changed over the last two decades. We sought to establish improved surgical/ventilation protocols for patients with omphaloceles requiring abdominal reconstruction. MethodsAn IRB-approved retrospective review was performed on patients with omphalocele requiring abdominal wall reconstruction by Plastics and/or Pediatric Surgery at a pediatric tertiary-care referral center (January 2006-July 2021). Birth history, comorbidities, surgical details, ventilation data, complications/recurrence were extracted. Results Of 129 patients screened, seven required Plastic Surgery involvement. Defect size was 102.9 cm2 (range: 24 - 178.5); four patients required component separation; zero patients received mesh; zero complications/recurrences were recorded. Two patients required postoperative ventilation for 2.5 days, based on increased peak inspiratory pressures at surgery stop versus start time.ConclusionPatients with large defects secondary to omphalocele benefit from collaboration between Pediatric and Plastic Surgery for component separation and primary fascial closure without mesh. Future research should follow patients who mature out of pediatric clinics to evaluate the incidence of hernias in adults with Plastic Surgery-repaired omphaloceles.
Expression pattern of Drug-Resistance Genes ERG11 and TAC1 in Candida albicans Clinical Isolates
Authors: Zare-Bidaki Majid , Maleki Anis , Ghanbarzadeh Nahid , Nikoomanesh Fatemeh 
Published: March 2022

Abstract
Background:Candida albicans (C. albicans) is an opportunistic fungus and the most common cause of vulvovaginal candidiasis (VVC). In recent years, the use of antifungal drugs has led to the incidence of drug resistance. The purpose of this study is two fold: to determine the relationship between risk factors and antifungal resistance among C. albicans isolates from women with VVC and to investigate the expression pattern of drug-resistance genes ERG11 and TAC1 in C. albicans isolates using real-time PCR.Methods and Results:This descriptive cross-sectional study was conducted on 50 C. albicans isolates from women with VVC. Antifungal susceptibility was tested for 4 azoles (fluconazole, itraconazole, voriconazole, clotrimazole) and amphotericin B via the microdilution methods per the testing standard M27-A3/S4 of the Clinical and Laboratory Standards Institute (CLSI). High susceptibility rates were recorded for itraconazole and voriconazole (68%), followed by ketoconazole (46%). Fluconazole had the smallest impact on C. albicans with 36% sensitivity The change in ERG11 and TAC1 genes expression was determined by qPCR, and the results revealed that ERG11 and TAC1 genes expression had overexpression in some fluconazole-sensitive isolates. The mRNA levels of ERG11 and TAC1 genes in fluconazole-resistant isolates compared to susceptible isolates increased by 1.1 and 3.1 times, respectively. Conclusion:The results revealed that drug resistance in C. albicans is not simply controlled by several genes but is a multi-factorial phenomenon, where several factors and mechanisms are involved in the process of drug resistance.
Clinical and Virological Features of the First Occurrence of COVID-19 Delta Variant in Anhui Province, China
Authors: He Jun , Wu Xiao-Min , Hou Sai , Feng Ya-Ting , Chen Xiao-Long , Gong Lei , Wang Wei , Chen Qing-Qing , Yu Jun-Ling , Li Wei-Wei , He Lan , Zhang Zhu-Hui , Wang Peng , Zhou Xue , Zhou Jian-Hua , Luo Wan-Rong , Yuan Yuan , Sun Yong , Su Bin , Pan Hai-Feng , Wu Jia-Bing , Wang Peng 
Published: March 2022

Abstract
Objectives
Since the outbreak of coronavirus disease 2019 (COVID-19), it has caused serious casualties worldwide. In recent months, the virus has mutated into an increasingly infectious form (Delta variant) and spread rapidly.
Methods
In the current study, we analyzed the clinical, epidemiological and viral genetic characteristics of the first four imported Delta cases in Anhui Province, China.
Results
The four imported Delta cases developed chest inflammation, tissue damage and recovered after admission, the serum high-sensitivity C-reactive protein (hs-CRP) and CRP levels showed a first increasing and then decreasing trend. The changes of hs-CRP /CRP and serum neutralizing antibodies (Nab) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) levels were associated with the regression of chest lesions. The combination of genetic sequencing and epidemiological analysis suggested that the SARS-CoV-2 delta variant infection of these four patients may originate from Russia.
Conclusions
Our study found the certain correlations of serum hs-CRP/CRP and Nab levels with the occurrence, development and outcome of COVID-19 delta variant, suggesting that monitoring hs-CRP/CRP and Nab levels of COVID-19 delta variant patients at hospital admission may be useful for understanding the severity of patients’ current conditions.
Air Pollutant Sulfur Dioxide is a Major Risk Factor for Pulmonary Tuberculosis Hospitalizations of HIV-infected Patients: Distribution Lag Non-linear Analyses
Authors: Wang Yaping , Chen Mingxiao , Deng Kai 
Published: March 2022

Abstract
Background: The relationship between air pollutants and pulmonary tuberculosis (PTB) in HIV-infected patients, an immunocompromised population, is unclear.Methods: The data of PTB cases among HIV-infected patients admitted to Guangzhou Eighth People’s Hospital, the local largest HIV/AIDS treatment clinic, as well as the meteorological factors and air pollutants between 2014 and 2019, were collected. The associations between air pollutants and PTB were evaluated in generalized linear model (GLM) and distributed lag non-linear model (DLNM). The robustness of results was tested by sensitivity analysis.Results: A total of 494 subjects were enrolled. PTB cases were decreased over time and significantly correlated with monthly mean concentrations of sulfur dioxide (SO2, r = 0.5, P < 0.001) but not other pollutants. In multi-pollutant GLM, SO2 was a risk factor of monthly PTB cases (relative risk [RR] =1.160, 95% confidence interval [CI]: 1.105-1.218) and fine particulate (PM2.5­) was a protective factor (RR = 0.971, 95% CI: 0.950-0.993). In single-pollutant DLNM, a 10-unit increase in SO2 concentration was significantly related to PTB cases within lag 0-6 months with the peak RR at lag 0 month (RR = 1.201, 95% CI: 1.028-1.403) and linearly decreased over lag months, and the cumulative effect reached the peak at lag 13 month (RR = 3.672, 95% CI = 1.052-12.81). In multi-pollutant DLNM, SO2 remained a risk factor of PTB within lag 0-3 months. PM2.5 was negatively associated with PTB at lag 18 month (RR = 0.900, 95% CI: 0.810-0.999 ) in single-pollutant DLNM and not significant in multi-pollutant DLNM.Conclusions: SO2 is identified as a major risk factor of PTB in HIV-infected patients.
Childbirth and Perinatal Outcomes of Healthy, Low-risk Pregnant Women With Abnormal Total Gestational Weight Gain.
Authors: Ornaghi Sara , Fumagalli Simona , Galimberti Sofia , Ornago Alice Margherita , Brivio Valentina , Lambicchi Laura , Nespoli Antonella , Vergani Patrizia 
Published: March 2022

Abstract
PurposeLittle is known on the potential effects of abnormal GWG among low-risk, healthy pregnant women with no comorbidities or gestational complications.We investigated perinatal outcomes of these pregnancies according to GWG as per the 2009 National Academy of Medicine (NAM) recommendations.MethodsA retrospective analysis of prospectively collected data of low-risk pregnant women giving birth after 370/7 weeks’ gestation at our center between 1/2016 and 12/2020. Only women with normal pregestational BMI (pBMI) (18.5-24.9 Kg/m2) and no pre- or gestational complications were included. Self-reported prepregnancy weight was used to calculate pBMI; GWG was the difference between maternal weight at childbirth and prepregnancy weight. Women were classified according to the 2009 NAM guidelines for GWG: insufficient (iGWG, <11.5 Kg), adequate (aGWG, 11.5-16 Kg), and excessive (eGWG, >16 Kg). Logistic regression analysis with aGWG as referent was performed to independent estimate dose-response associations.ResultsDuring the study period, there were 4,127 (33.1%) births fulfilling the inclusion criteria. Fifty-two percent of women gained outside the recommended range: 33.5% had iGWG and 18.7% eGWG. iGWG women were 40% more likely to have early-term births and SGA neonates. In turn, eGWG women displayed increased odds of prolonged pregnancy (aOR 1.32), cesarean section in labor (aOR 1.50), high-degree perineal tears (aOR 2.04, postpartum hemorrhage >1000 mL (aOR 1.54), and LGA newborns (aOR 1.83).ConclusionOur data show that abnormal GWG can independently associate with heightened risk of adverse outcomes among healthy, low-risk pregnant women with normal pBMI and no comorbidities or gestational complications.
Kinematic Analysis Of Hurdles Clearance Techniques And The First Inter-Hurdle Stride Over 110-Metre Hurdles: Comparisons Between Specialists And Decathletes
Authors: Mansour Hamda , Chaifa Mounira Ben , Atta Ibrahim , Alhumaid Majed M. , Said Mohamed Ahmed 
Published: March 2022

Abstract
Background: Performances in the 110-metre hurdles sprint differ for Elite Hurdles Specialists (EHS) and Elite Decathletes (ED), possibly resulting in technical differences. This study aims to compare the kinematics of hurdle clearance and the first stride inter-hurdles of EHS and ED. Methods: This is a cross-sectional study involving twenty male athletes volunteered for the investigation (10 male EHS, and 10 male ED). Each athlete had previously achieved a 110m hurdles in a real competitive practice situation, and the kinematic parameters were determined by using kinematic analysis. The indices of spatial and temporal interaction in the support phase, as well as the angular parameters of motion and height of the body center of mass (CM) for various postures, were determined. Results: EHS were characterized by faster hurdle crossing (p < 0.01), shorter stride length over the hurdle (p < 0.05), and a shorter support phase in the first stride post-hurdle (p < 0.01). The CM path of ED was higher than that of EHS (p < 0.01). EHS attack the hurdle with the lead leg knee significantly more flexed (p < 0.001) and after crossing the hurdle, regain contact with the ground with the lead leg more flexed at the hip level (p < 0.01), the trunk more inclined forward (p < 0.01), and a relatively smaller positioning angle of the supporting leg (p < 0.05). Conclusions: EHS were distinguished by maintaining efficient sprinting mechanics over the hurdles, enabling them to develop optimal velocity between hurdles. This was reflected in both a shorter impulse time and a considerable reduction of braking forces at the touchdown. In addition, EHS showed a more fluid and quicker resumption of optimal speed between hurdles, resulting in minimal loss of speed and superior performance.
The Clustering, Distribution, Bioaccumulation and Translocation as an Ability of Mangrove Vegetation to Reduce Impact of Heavymetal (Hg, Cd and Zn) Pollution
Authors: Hilmi Endang , Dewi Rose , Sudiana Eming , Mahdiana Arif , Cahyo Tri Nur 
Published: March 2022

Abstract
Mangrove has ability to reduce impact of heavy metal contaminant released from industry and domestic waste. . Therefore, this study aimed to analyze interpolation and clustering of heavy metal accumulation and traslocation in mangrove ecosystem.. The results showed the accumulation of Mercury in water, stem and bark, leaves, and roots were 0.1347±0.0212 ppm, 0.0137±0.0137 ppm, 0.0110-0.0640 ppm, 0.0020-0.0120 ppm, and 0.0260-0.0690 ppm. Cadmium accumulations between 1.6048±0.3595 ppm, 0.0292±0.0047 ppm, 0.0790-0.2650 ppm, 0.0130-0.0480 ppm, and 0.1560-0.2300 ppm. Furthermore, Zinc had score that were 35.1746±5.4856 ppm, 0.0550±0.0095 ppm, 10.3250-32.4490 ppm, 7.1200-23.4150 ppm, and 16.7170-39.1200 ppm. However, bioaccumulation factors of Hg ranged between 0.0210-0.4751, Cd 0.0105-0.1541, and Zn 0.2807-1.2506 with the translocation factors of 0.0459-1.0547 (Hg), 0.0642-1.3855 (Cd), and 0.4086-1.3057 (Zn). The mangrove landscape showed that of Sonneratia alba (best of Hg accumulation), Rhizophora mucronata (best of Cd accumulation), Avicennia marina (best of Zn accumulation)
A necroptosis-related lncRNA signature can accurately predict the survival outcome of bladder cancer patients
Authors: Ma Zhifang , Zhang Wei , Wang Wei , Wang Shen , Song Liying , Ren Zhaoyu , Bai Zhongyuan , Wang Fang , Zhao Ruijie , Gao Yaran 
Published: March 2022

Abstract
Bladder cancer is the second most common malignant tumor in the male genitourinary system. This study explored the prognostic role of necroptosis-related long noncoding RNAs (LncRNAs) in bladder cancer.We used univariate Cox, least absolute shrinkage and selection operator and multivariate Cox regression models to establish a necroptosis-related lncRNA prognostic signature. Then, 13 necroptosis-related lncRNAs were included in risk signature. Patients were divided into the high- and low-risk group based on the median risk score. The risk signature predicted that the areas under the receiver operating characteristic curve of patients at 1 year, 3 years and 5 years were 0.74, 0.78 and 0.79, respectively. Next, nomograms and correction curves were established using risk signature and clinicopathological factors. The nomogram-corrected curve shows a good fit. Gene Set Enrichment Analysis was used to explore the possible molecular mechanisms underlying the different prognosis of the low-risk and high-risk of patients, and showed that tumor-related signaling pathways and intercellular connectivity-related signaling pathways were significantly enriched in the high-risk group, while metabolism-related pathways were enriched in the low-risk group. In addition, Immune cell infiltration analysis and was performed on the two groups of patients and the response to immunotherapy was judged. Finally, tumor mutation data were analyzed, and potentially sensitive chemotherapy drugs were screened. The low-risk group was more sensitive to methotrexate while the patients in the high-risk group were more sensitive to cisplatin, docetaxel, paclitaxel and thapsigargin.
Green construction and release mechanism of lignin-based double-layer coated urea
Authors: Chen Xiaojuan , Yang Huchen , Zhang Lidan , Li Zhongli , Xue Yunna , Wang Rongfeng , Fan Xiaolin , Sun Shaolong 
Published: March 2022

Abstract
Background: Currently, there are few reports about the sustained-release time of single-layer non-modified lignin-based coated urea that meets the sustained-release standard. Therefore, the unmodified lignin-based material by adding a hydrophobic polymer can improve the hydrophobicity of the coating material.Results: A novel green double layer coating with lignin-based polyurethane (LPU) as the inner coating and epoxy resin (EP) as the outer coating was effectively constructed for coated urea. Fourier transform infrared spectra confirmed that lignin and polycaprolactone diol successfully reacted with Hexamethylene diisocyanate. The loss weight and water contact angle (WCA, 75.6-63.6°) of the LPUs decreased with the increased lignin content. The average particle hardness of the LDCU first increased from 58.1 N (lignin of 30%) to 67.0 N (lignin of 60%), but then decreased to 62.3 N (lignin of 70%). The release longevity of the coated urea was closely related to the preparation parameters of the coating material. The optimal cumulative nutrient release rate (79.4%) of LDCU was obtained (lignin of 50%, -CNO/-OH molar ratios of 1.15, EP of 35%, and coating ratio of 5%). The aggregates of hydrone on the LDCU caused the dissolution and swelling of nutrients, and then the diffusion of nutrients through the concentration gradient. Conclusion: Although the nutrient release of the LDCUs was affected by many factors, the successful development of the LDCUs will improve the rapid development of the coated fertilizer industry.
Clinicopathological characteristics and outcomes of cryoglobulinemic glomerulonephritis due to different causes
Authors: xia Yuanyuan , Lv Yanan , Fan Yun , Li Xiaomei , Liang Shaoshan , Liang Dandan , Xu Feng , Yang Fan , Zhu Xiaodong , Zhang Mingchao , Zeng Caihong 
Published: March 2022

Abstract
Background: Renal involvement is one of the poor prognostic factors in patients with cryoglobulinemia. Finding out the role of monoclonal immunoglobulin (MIg) in biopsy proven cryoglobulinemic glomerulonephritis (CGN) and exploring the clinicopathological characteristics and outcomes of CGN are of great significance.Methods: Forty patients with CGN from a single center were recruited in this retrospective study. Their clinical, pathologic, and follow-up data were collected and analyzed. According to whether the serum monoclonal immunoglobulin (MIg) and HBV-DNA/HBV markers or HCV-RNA/anti-HCV antibodies were positive or not, they were divided into four groups: positive serum MIg only (MIg group), positive HBV-DNA/HBV markers or HCV-RNA/anti-HCV antibodies (HBV/HCV) only (HBV/HCV group), positive serum MIg and HBV/HCV (MIg+HBV/HCV group), and all MIg/HBV/HCV negative group.Results: There were 24 males and 16 females, with a mean age of 47.8 years. Hypertension was presented in 70% of cases, anemia in 75%, renal insufficiency in 57.5%, nephrotic proteinuria in 57.5% and microscopic hematuria in 95%. 39 patients had a median follow-up of 24.9 months, and 28.9% of them progressed to end-stage renal disease (ESRD). MIg group had the highest incidence of renal insufficiency. The median serum creatinine (Scr) of patients in MIg group was significantly higher than those in HBV/HCV or MIg/HBV/HCV negative groups (P＜0.05). Membranoproliferative GN (MPGN) was the predominant histologic pattern( 38/40, 92.5%）. Glomerular Igs deposition in CGN were presented as three forms: consistent with serum MIg, single Igs deposition (IgM more than IgG) and multiple Igs deposition. MIg group had a higher incidence of ESRD than HBV/HCV group. Independent predictors of ESRD by multivariate analysis was positive serum MIg.Conclusion: CGN has varied clinical, pathological characteristics and prognosis in different groups. Patients with positive serum MIg alone in CGN had worse renal dysfunction and poor renal outcome, and serum MIg was the independent prognostic factor.