bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal information interaction in multilayer directed network based on cross-frequency integration of mild cognitive impairment and Alzheimer’s disease
Authors: Xue Jiayue , Yao Rong , Cui Xiaohong , Wang Bin , Wei Jing , Wu Xubin , Sun Jie , Yang Yanli , Xiang Jie , Liu Yi 
Published: September 2022

AbstractMild cognitive impairment (MCI) and Alzheimer’s disease (AD) have been reported to result in abnormal cross-frequency integration. However, previous studies have failed to consider specific abnormalities in receiving and outputting information among frequency bands during integration. Here, we investigated heterogeneity in receiving and outputting information during cross-frequency integration in patients. The results showed that during cross-frequency integration, information interaction first increased and then decreased, manifesting in the heterogeneous distribution of inter-frequency nodes for receiving information. A possible explanation was that due to damage to some inter-frequency hub nodes, intra-frequency nodes gradually became new inter-frequency nodes, whereas original inter-frequency nodes gradually became new inter-frequency hub nodes. Notably, damage to the brain regions that receive information between layers was often accompanied by a strengthened ability to output information and the emergence of hub nodes for outputting information. Moreover, an important compensatory mechanism assisted in the reception of information in the cingulo-opercular and auditory networks and in the outputting of information in the visual network. This study revealed specific abnormalities in information interaction and compensatory mechanism during cross-frequency integration, providing important evidence for understanding cross-frequency integration in patients with MCI and AD.
Haros graphs: an exotic representation of real numbers
Authors: Calero-Sanz Jorge , Luque Bartolo , Lacasa Lucas 
Published: September 2022

AbstractThis article introduces Haros graphs, a construction which provides a graph-theoretical representation of real numbers in the unit interval reached via paths in the Farey binary tree. We show how the topological structure of Haros graphs yields a natural classification of the real numbers into a hierarchy of families. To unveil such classification, we introduce an entropic functional on these graphs and show that it can be expressed, thanks to its fractal nature, in terms of a generalized de Rham curve. We show that this entropy reaches a global maximum at the reciprocal of the Golden number and otherwise displays a rich hierarchy of local maxima and minima that relate to specific families of irrationals (noble numbers) and rationals, overall providing an exotic classification and representation of the reals numbers according to entropic principles. We close the article with a number of conjectures and outline a research programme on Haros graphs.
Transjugular closure of a residual septal device defect: a case report
Authors: Hernandez Felipe Hernandez , Linares Vicente Jose A , Muñoz David Ibañez , Ruiz Arroyo Jose R 
Published: September 2022

Abstract

Background
Severe residual shunts after percutaneous closure of atrial septal defects are unusual. These patients are usually considered candidates for surgery.

Case summary
We describe the transjugular closure of a residual atrial septal defect with significant left-to-right shunt due to a malpositioned large atrial septal device in a symptomatic 74-year-old female. Transjugular access was chosen first due to the unfavourable position of the device for delivery of a new one from the femoral approach. An overlapping Figulla® Flex II 27/30 mm PFO device was successfully implanted with the guidance of 3D-transoesophageal echocardiography.

Discussion
This case demonstrates the safety and feasibility of transjugular access as an alternative to femoral or transhepatic approaches in patients with difficult atrial septal anatomies, who are usually referred for surgery.
Successful transvenous implantable cardioverter-defibrillator implantation supported by preceding 3D electro-anatomical mapping for a ventricular fibrillation survivor with surgically repaired congenitally corrected transposition of the great arteries: a case report
Authors: Mitama Tadayuki , Kabutoya Tomoyuki , Kashihara Kana Kubota , Kario Kazuomi 
Published: September 2022

Abstract

Background
The atrial sites suitable for lead placement are limited after complex surgical atrial procedures, and lead placement can be challenging in patients with congenitally corrected transposition of the great arteries (ccTGA) after intracardiac repair.

Case summary
A 34-year-old man with ccTGA, who had undergone a double-switch operation with combined Senning and Jatene operations at the age of 14 was transferred to us. He experienced faintness and suffered cardiopulmonary arrest, and electrocardiography revealed ventricular fibrillation. After conversion to sinus rhythm by urgent external defibrillation, sinus bradycardia was revealed. Electrophysiological study was done using a three-dimensional (3D) mapping system (Ensite®) to evaluate the electrical condition of atria and to decide whether atrial lead can be transvenously placed. The electrical potential of the functional right atrium was good in the lateral or posterior wall, but the threshold was high. By contrast, the roof of the functional right atrium beyond cavoatrial junction was characterized by low voltage, but in a limited region of the roof of right atrium, the threshold was satisfactory and the electrical potential was normal. Thus, 3 weeks later, we implanted a transvenous implantable cardioverter-defibrillator (ICD). We used a 3D mapping system to place the atrial lead in the limited region of the roof of the right atrium mentioned above, the threshold was 0.7 V.

Discussion
Electrophysiological examination using a 3D mapping system before implantation of a dual-chamber ICD is useful because atrial sites suitable for lead placement are limited in patients.
Electromechanical factors associated with favourable outcome in cardiac resynchronization therapy
Authors: Maffessanti Francesco , Jadczyk Tomasz , Wilczek Jacek , Conte Giulio , Caputo Maria Luce , Gołba Krzysztof S , Biernat Jolanta , Cybulska Magdalena , Caluori Guido , Regoli François , Krause Rolf , Wojakowski Wojciech , Prinzen Frits W , Auricchio Angelo 
Published: September 2022

AbstractAimsElectromechanical coupling in patients receiving cardiac resynchronization therapy (CRT) is not fully understood. Our aim was to determine the best combination of electrical and mechanical substrates associated with effective CRT.Methods and resultsSixty-two patients were prospectively enrolled from two centres. Patients underwent 12-lead electrocardiogram (ECG), cardiovascular magnetic resonance (CMR), echocardiography, and anatomo-electromechanical mapping (AEMM). Remodelling was measured as the end-systolic volume (ΔESV) decrease at 6 months. CRT was defined effective with ΔESV ≤ −15%. QRS duration (QRSd) was measured from ECG. Area strain was obtained from AEMM and used to derive systolic stretch index (SSI) and total left-ventricular mechanical time. Total left-ventricular activation time (TLVAT) and transeptal time (TST) were derived from AEMM and ECG. Scar was measured from CMR. Significant correlations were observed between ΔESV and TST [rho = 0.42; responder: 50 (20–58) vs. non-responder: 33 (8–44) ms], TLVAT [−0.68; 81 (73–97) vs. 112 (96–127) ms], scar [−0.27; 0.0 (0.0–1.2) vs. 8.7 (0.0–19.1)%], and SSI [0.41; 10.7 (7.1–16.8) vs. 4.2 (2.9–5.5)], but not QRSd [−0.13; 155 (140–176) vs. 167 (155–177) ms]. TLVAT and SSI were highly accurate in identifying CRT response [area under the curve (AUC) &gt; 0.80], followed by scar (AUC &gt; 0.70). Total left-ventricular activation time (odds ratio = 0.91), scar (0.94), and SSI (1.29) were independent factors associated with effective CRT. Subjects with SSI &gt;7.9% and TLVAT &lt;91 ms all responded to CRT with a median ΔESV ≈ −50%, while low SSI and prolonged TLVAT were more common in non-responders (ΔESV ≈ −5%).ConclusionElectromechanical measurements are better associated with CRT response than conventional ECG variables. The absence of scar combined with high SSI and low TLVAT ensures effectiveness of CRT.
Carbon footprint of atrial fibrillation catheter ablation
Authors: Ditac Geoffroy , Cottinet Pierre-Jean , Quyen Le Minh , Grinberg Daniel , Duchateau Josselin , Gardey Kévin , Dulac Arnaud , Delinière Antoine , Haddad Christelle , Boussuge-Roze Julie , Sacher Frédéric , Jaïs Pierre , Chevalier Philippe , Bessière Francis 
Published: September 2022

AbstractAimsClimate change represents the biggest global health threat of the 21st century. Health care system is itself a large contributor to greenhouse gas (GHG) emissions. In cardiology, atrial fibrillation (AF) catheter ablation is an increasing activity using numerous non-reusable materials that could contribute to GHG emission. Determining a detailed carbon footprint analysis of an AF catheter ablation procedure allows the identification of the main polluting sources that give opportunities for reduction of environmental impact. To assess the carbon footprint of AF catheter ablation procedure. To determine priority actions to decrease pollution.Methods and resultsAn eco-audit method used to predict the GHG emission of an AF catheter ablation procedure was investigated. Two workstations were considered including surgery and anaesthesia. In the operating room, every waste produced by single-use medical devices, pharmaceutical drugs, and energy consumption during intervention were evaluated. All analyses were limited to the operating room. Thirty procedures were analysed over a period of 8 weeks: 18 pulmonary veins isolation RF ablations, 7 complex RF procedures including PVI, roof and mitral isthmus lines, ethanol infusion of the Marshall vein and cavo tricuspid isthmus line, and 5 pulmonary vein isolation with cryoballoon. The mean emission during AF catheter ablation procedures was 76.9 kg of carbon dioxide equivalent (CO2-e). The operating field accounted for 75.4% of the carbon footprint, while only 24.6% for the anaesthesia workstation. On one hand, material production and manufacturing were the most polluting phases of product life cycle which, respectively, represented 71.3% (54.8 kg of CO2-e) and 17.0% (13.1 kg of CO2-e) of total pollution. On the other hand, transport contributed in 10.6% (8.1 kg of CO2-e), while product use resulted in 1.1% (0.9 kg of CO2-e) of GHG production. Electrophysiology catheters were demonstrated to be the main contributors of environmental impact with 29.9 kg of CO2-e (i.e. 38.8%). Three dimensional mapping system and electrocardiogram patches were accounting for 6.8 kg of CO2-e (i.e. 8.8% of total).ConclusionAF catheter ablation involves a mean of 76.9 kg of CO2-e. With an estimated 600 000 annual worldwide procedures, the environmental impact of AF catheter ablation activity is estimated equal to 125 tons of CO2 emission each day. It represents an equivalent of 700 000 km of car ride every day. Electrophysiology catheters and patches are the main contributors of the carbon footprint. The focus must be on reducing, reusing, and recycling these items to limit the impact of AF ablation on the environment. A road map of steps to implement in different time frames is proposed.
Extended LH administration as a strategy to increase the pool of recruitable antral follicles in hypothalamic amenorrhea: evidence from a case series
Authors: La Marca Antonio , Longo Maria 
Published: September 2022

Abstract
New evidence is indicating a growing role of LH in promoting ovarian follicular growth and maturation, even at the early stages. LH seems to enhance the transition of follicles to the antral stage hence leading to an increase in the so-called functional ovarian reserve (recruitable antral follicles). Hypogonadotropic hypogonadism is characterized by low, and sometimes undetectable, serum LH and FSH levels, which may indeed explain the low anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) found in patients affected by this condition. We report here the cases of two young women affected by hypothalamic amenorrhea (HA) that presented for fertility treatment with very low functional ovarian reserve. The two patients were treated with exogenous LH for 1 and 2 months (extended LH administration: ELHA) at the dose of 187.5 IU LH every day and 150 IU LH every other day, respectively. In both the cases there was an increase in serum AMH levels and in the AFC. In one patient, the AMH and AFC increased from a baseline 1.3 ng/ml and 8 to 2.3 ng/ml and 14 at end of treatment, respectively. In the second case, serum AMH and AFC increased from 0.4 ng/ml and 6 to 1.6 ng/ml and 13, respectively. One patient underwent ovarian stimulation before and after ELHA, showing an increase in the number of mature oocytes recruited (3 versus 8 metaphase II (MII) oocytes before and after, respectively). The second patient underwent an IVF cycle after ELHA resulting in the retrieval of six MII oocytes and an ongoing pregnancy following transfer of a single blastocyst. Women with HA are characterized by chronic, low levels of gonadotrophins, which may impact not only on the cyclic recruitment of follicles but also the progression of small growing follicles through the first stages of folliculogenesis. Some women with HA may in fact show very low serum AMH and AFC. Our case series shows that the administration of LH at a dose of at least 150–187.5 IU every day or every other day may contribute to a clinically evident increase in the functional ovarian reserve (AFC), and probably accounts for a positive effect of LH on the progression of follicles throughout the early stages of folliculogenesis.
Slow Waning of Antibodies Following BNT162b2 as a Third Dose in Adults Who Had Previously Received 2 Doses of Inactivated Vaccine
Authors: Cowling Benjamin J , Cheng Samuel M S , Martín-Sánchez Mario , Au Niki Y M , Chan Karl C K , Li John K C , Fung Lison W C , Luk Leo L H , Tsang Leo C H , Ip Dennis K M , Poon Leo L M , Leung Gabriel M , Peiris J S Malik , Leung Nancy H L 
Published: September 2022

Abstract
We administered BNT162b2 as a third dose to 314 adults aged ≥30 years who had previously received 2 doses of inactivated vaccine. We collected blood samples before the third dose and again after 1 month and 6 months, and found robust antibody responses to the ancestral strain at 6 months after receipt of BNT162b2. Antibody responses to Omicron BA.2 by live virus neutralization were weaker after the third dose and had declined to a low level by 6 months.
A comprehensive review of traditional uses, phytochemistry and pharmacology of Reynoutria genus
Authors: Zhang Zi-Long , Li Yu-Ze , Wu Guo-Qing , Zhang Dong-Dong , Deng Chong , Wang Zhi-Min , Song Xiao-Mei , Wang Wei 
Published: September 2022

Abstract

Objectives
The genus Reynoutria belonging to the family Polygonaceae is widely distributed in the north temperate zone and used in folk medicine. It is administered as a sedative, tonic and digestive, also as a treatment for canities and alopecia. Herein, we reported a review on traditional uses, phytochemistry and pharmacology reported from 1985 up to early 2022. All the information and studies concerning Reynoutria plants were summarized from the library and digital databases (e.g. ScienceDirect, SciFinder, Medline PubMed, Google Scholar, and CNKI).

Key findings
A total of 185 articles on the genus Reynoutria have been collected. The phytochemical investigations of Reynoutria species revealed the presence of more than 277 chemical components, including stilbenoids, quinones, flavonoids, phenylpropanoids, phospholipids, lactones, phenolics and phenolic acids. Moreover, the compounds isolated from the genus Reynoutria possess a wide spectrum of pharmacology such as anti-atherosclerosis, anti-inflammatory, antioxidative, anticancer, neuroprotective, anti-virus and heart protection.

Summary
In this paper, the traditional uses, phytochemistry and pharmacology of genus Reynoutria were reviewed. As a source of traditional folk medicine, the Reynoutria genus have high medicinal value and they are widely used in medicine. Therefore, we hope our review can help genus Reynoutria get better development and utilization.
The transcription factors DcHB30 and DcWRKY75 antagonistically regulate ethylene-induced petal senescence in carnation (Dianthus caryophyllus)
Authors: Xu Han , Wang Siqi , Larkin Robert M , Zhang Fan 
Published: September 2022

Abstract
Although numerous transcription factors with antagonistic activities have been shown to contribute to growth and development, whether and how they regulate senescence in plants is largely unknown. In this study, we investigated the role of antagonistic transcription factors in petal senescence in carnation (Dianthus caryophyllus), one of the most common types of ethylene-sensitive cut flowers produced worldwide. We identified DcHB30 that encodes a ZF-HD transcription factor that is down-regulated in ethylene-treated petal transcriptomes. We found that silencing DcHB30 accelerated ethylene-induced petal senescence and that DcHB30 physically interacts with DcWRKY75, a positive regulator of ethylene-induced petal senescence. Phenotypic characterization and molecular evidence indicated that DcHB30 and DcWRKY75 competitively regulate the expression of their co-targeted genes DcACS1, DcACO1, DcSAG12, and DcSAG29 by reciprocally inhibiting the DNA-binding activity of each other on the gene promoters. This transcriptional regulation mechanism demonstrates that these transcription factors serve as positive and negative regulators in ethylene-induced petal senescence in carnation. Thus, our study provides insights into how antagonizing transcription factors regulate plant senescence.
Contributing Factors to Israeli Soldiers’ Adaptation to Military Noncombat Positions
Authors: Yakobi Michal , Dekel Rachel , Yavnai Nirit , Ben Yehuda Ariel , Shelef Leah 
Published: September 2022

ABSTRACT

Objective
Adjusting to a military environment is a complex process, with unique demands and various stressors placed on conscripts. In this study, we examined the unique and combined contribution of the independent variables that constitute an individual soldier’s personal resources—the meaningfulness of the military role and the match between expectations and the job itself; cognitive flexibility; social support; and seeking help from a mental health officer (MHO)—to the adaptation (dependent variable) of noncombat soldiers to military service.

Method
The study group comprised 200 Israel Defense Forces noncombat soldiers aged 18-23 years (Meanage = 20.046 years, SD = 0.951). Of them, 107 (53.3%) had consulted a MHO. The remaining soldiers who had not consulted an MHO (n = 93, 46.5%) served as the comparison group. Research tools included the work and meaning questionnaire, the Cognitive Flexibility Scale, the Medical Outcomes Study (social support) questionnaire, and adaptation to the army questionnaire.

Results
Adaptation to service was found to relate positively to the meaningfulness of the military role, cognitive flexibility, and social support. Social support partially mediated the relation between cognitive flexibility and adaptation to service. Additionally, soldiers who had consulted an MHO had lower levels of cognitive flexibility and social support, and they adapted less well to service compared to the comparison group.

Conclusions
The study indicates that soldiers who seek help have lower resources. Additional personal and environmental variables that contribute to the adjustment of soldiers in noncombat positions were also identified.
Measurement of AGN dust extinction based on the near-infrared flux variability of WISE data
Authors: Mizukoshi Shoichiro , Minezaki Takeo , Tsunetsugu Shoichi , Yoshida Atsuhiro , Sameshima Hiroaki , Kokubo Mitsuru , Noda Hirofumi 
Published: September 2022

ABSTRACT
We present the measurement of the line-of-sight extinction of the dusty torus for a large number of obscured active galactic nuclei (AGNs) based on the reddening of the colour of the variable flux component in near-infrared (NIR) wavelengths. We collected long-term monitoring data by Wide-field Infrared Survey Explorer (WISE) for 513 local AGNs catalogued by the Swift/BAT AGN Spectroscopic Survey (BASS) and found that the multi-epoch NIR flux data in two different bands (WISE W1 and W2) are tightly correlated for more than 90 per cent of the targets. The flux variation gradient (FVG) in the W1 and W2 bands was derived by applying linear regression analysis, and we reported that those for unobscured AGNs fall in a relatively narrow range, whereas those for obscured AGNs are distributed in a redder and broader range. The AGN’s line-of-sight dust extinction (AV) is calculated using the amount of the reddening in the FVG and is compared with the neutral hydrogen column density (NH) of the BASS catalogue. We found that the NH/AV ratios of obscured AGNs are greater than those of the Galactic diffuse interstellar medium (ISM) and are distributed with a large scatter by at most two orders of magnitude. Furthermore, we found that the lower envelope of the NH/AV of obscured AGNs is comparable to the Galactic diffuse ISM. These properties of the NH/AV can be explained by increase in the NH attributed to the dust-free gas clouds covering the line of sight in the broad-line region.
A Bayesian calibration framework for EDGES
Authors: Murray Steven G , Bowman Judd D , Sims Peter H , Mahesh Nivedita , Rogers Alan E E , Monsalve Raul A , Samson Titu , Vydula Akshatha Konakondula 
Published: September 2022

ABSTRACT
We develop a Bayesian model that jointly constrains receiver calibration, foregrounds, and cosmic 21 cm signal for the EDGES global 21 cm experiment. This model simultaneously describes calibration data taken in the lab along with sky-data taken with the EDGES low-band antenna. We apply our model to the same data (both sky and calibration) used to report evidence for the first star formation in 2018. We find that receiver calibration does not contribute a significant uncertainty to the inferred cosmic signal ($\lt 1{{\ \rm per\ cent}}$), though our joint model is able to more robustly estimate the cosmic signal for foreground models that are otherwise too inflexible to describe the sky data. We identify the presence of a significant systematic in the calibration data, which is largely avoided in our analysis, but must be examined more closely in future work. Our likelihood provides a foundation for future analyses in which other instrumental systematics, such as beam corrections and reflection parameters, may be added in a modular manner.