bluuebunny/crossref_metadata_2025_split huggingface dataset:
A revised application of cognitive presence automatic classifiers for MOOCs: a new set of indicators revealed?
Authors: Hu Yuanyuan , Donald Claire , Giacaman Nasser 
Published: September 2022

AbstractAutomatic analysis of the myriad discussion messages in large online courses can support effective educator-learner interaction at scale. Robust classifiers are an essential foundation for the use of automatic analysis of cognitive presence in practice. This study reports on the application of a revised machine learning approach, which was originally developed from traditional, small-scale, for-credit, online courses, to automatically identify the phases of cognitive presence in the discussions from a Philosophy Massive Open Online Course (MOOC). The classifier performed slightly better on the MOOC discussions than similar previous studies have found. A new set of indicators to identify cognitive presence was revealed in the MOOC discussions, unlike those in the traditional courses. This study also cross-validated the classifier using MOOC discussion data from three other disciplines: Medicine, Education, and Humanities. Our results suggest that the cognitive classifier trained using MOOC data in only one discipline cannot yet be applied to other disciplines with sufficient accuracy.
Collective phenomena in a quasi-classical electron fluid within the interpolational self-consistent method of moments
Authors: Syzganbayeva S. A. , Ara J. , Askaruly A. , Ashikbayeva A. B. , Tkachenko I. M. , Arkhipov Y. V. 
Published: September 2022

Abstract
Collective processes in a quasi-classical electron gas are investigated within the framework of the interpolational self-consistent method of moments, which makes it possible to express the dispersion and decrement of plasma waves, and the dynamic structural factor of the system exclusively in terms of its static structural factor so that five sum rules are satisfied automatically. Different models are used of the static structure factor; the stability and robustness of the results of the moment approach taking into account the accuracy of these models is confirmed and tested by comparison to the alternative molecular dynamics simulation data.
Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric mesenchyme by balancing SHH and BMP4 signaling
Authors: Deuper Lena , Meuser Max , Thiesler Hauke , Jany Ulrich W. H. , Rudat Carsten , Hildebrandt Herbert , Trowe Mark-Oliver , Kispert Andreas 
Published: September 2022

ABSTRACT
The coordinated development of the mesenchymal and epithelial progenitors of the murine ureter depends on a complex interplay of diverse signaling activities. We have recently shown that epithelial FGFR2 signaling regulates stratification and differentiation of the epithelial compartment by enhancing epithelial Shh expression, and mesenchymal SHH and BMP4 activity. Here, we show that FGFR1 and FGFR2 expression in the mesenchymal primordium impinges on the SHH/BMP4 signaling axis to regulate mesenchymal patterning and differentiation. Mouse embryos with conditional loss of Fgfr1 and Fgfr2 in the ureteric mesenchyme exhibited reduced mesenchymal proliferation and prematurely activated lamina propria formation at the expense of the smooth muscle cell program. They also manifested hydroureter at birth. Molecular profiling detected increased SHH, WNT and retinoic acid signaling, whereas BMP4 signaling in the mesenchyme was reduced. Pharmacological activation of SHH signaling in combination with inhibition of BMP4 signaling recapitulated the cellular changes in explant cultures of wild-type ureters. Additional experiments suggest that mesenchymal FGFR1 and FGFR2 act as a sink for FGF ligands to dampen activation of Shh and BMP receptor gene expression by epithelial FGFR2 signaling.
A desert bee thermoregulates with an abdominal convector during flight
Authors: Johnson Meredith G. , Glass Jordan R. , Harrison Jon F. 
Published: September 2022

ABSTRACT
Flying endothermic insects thermoregulate, likely to improve flight performance. Males of the Sonoran Desert bee, Centris caesalpiniae, seek females at aggregations beginning at sunrise and cease flight near midday when the air temperature peaks. To identify the thermoregulatory mechanisms for C. caesalpiniae males, we measured tagma temperature, wingbeat frequency, water loss rate, metabolic rate and tagma mass of flying bees across shaded air temperatures of 19–38°C. Surface area, wet mass and dry mass declined with air temperature, suggesting that individual bees do not persist for the entire morning. The largest bees may be associated with cool, early mornings because they are best able to warm themselves and/or because they run the risk of overheating in the hot afternoons. Thorax temperature was high (38–45°C) and moderately well regulated, while head and abdomen temperatures were cooler and less controlled. The abdominal temperature excess ratio increased as air temperature rose, indicating active heat transfer from the pubescent thorax to the relatively bare abdomen with warming. Mass-specific metabolic rate increased with time, and air and thorax temperatures, but wingbeat frequency did not vary. Mass-specific water loss rate increased with air temperature, but this was a minor mechanism of thermoregulation. Using a heat budget model, we showed that whole-body convective conductance more than doubled through the morning, providing strong evidence that the primary mechanism of regulating thorax temperature during flight for these bees is increased use of the abdomen as a convector at higher air temperatures.
Spontaneous coronary artery dissection in cutis laxa
Authors: Charters Pia Frances Pemberton , McKenzie Daniel Barnaby , Rodrigues Jonathan Carl Luis , Loughborough William Wynn 
Published: September 2022

We describe the case of a 21-year-old female with Cutis Laxa presenting with an acute coronary syndrome. A CT coronary angiogram (CTCA) diagnosed spontaneous coronary artery dissection (SCAD) of the right coronary artery, which was successfully managed with medical therapy. Cutis Laxa is a rare connective-tissue disorder in which the skin becomes inelastic. Lax, redundant skin hangs in folds give a prematurely aged appearance and several forms of the disease have been described. Although certain cardiovascular complications are recognised in Cutis Laxa, to our knowledge SCAD has not been previously described. SCAD is an uncommon cause of acute coronary syndrome and sudden cardiac death. The condition particularly affects young females, those with connective tissue diseases, arteriopathies, pregnant females, contraceptive use and cocaine use. Atherosclerotic risk factors are seldom reported. The condition is underdiagnosed as symptoms may not generate a high index of clinical suspicion in this demographic. Diagnosis is traditionally made on invasive coronary angiogram although the procedure carries risks in SCAD and non-invasive CTCA should be considered in appropriately selected patient cohorts or as an adjunctive measure to assess for extracoronary vascular abnormalities. Our patient was diagnosed on CTCA, avoiding the need for invasive catheter angiogram.
Population-Level Evidence of the Gender Gap in Technology Entrepreneurship
Authors: Miric Milan , Yin Pai-Ling , Fehder Daniel C. 
Published: September 2022

This study investigates the gender gap in entrepreneurship in the technology industry. Digitization has created vast economic opportunities in the technology sector and has lowered many barriers to entry, thus reducing traditional frictions regarding entrepreneurship and potentially increasing opportunities for female founders. However, anecdotal evidence has suggested that female technology founders are rare and that women are underrepresented in science, technology, engineering, and mathematics roles. Based on individual career histories collected from more than 42 million U.S.-based LinkedIn profiles, including more than 1.3 million founders, we explore whether there are higher rates of female founders in technology companies relative to other industries. Our analysis revealed the following: (1) Females were only half as likely as males to found businesses in the technology industry. (2) Females were less likely to found successive businesses (i.e., serial founders), which was even more pronounced in the technology industry. (3) When we used the gender gap in labor force participation as a baseline, the gender gap in technology entrepreneurship was particularly large, even compared with other male-dominated industries (e.g., construction). (4) The gender gap in technology entrepreneurship was driven by lower rates of entrepreneurship by females in lower positions in the organizational hierarchy. In contrast, females who reached the C-suite in technology sectors were 16% more likely to found firms compared with their female C-suite counterparts in nontechnology industries. Combined, the results provide a nuanced view of the gender gap in entrepreneurship. Funding: Research support was provided by the Grief Center for Entrepreneurship Research and the Institute for Outlier Research in Business. Supplemental Material: The online appendix is available at https://doi.org/10.1287/stsc.2022.0170 .
The voice of ostomates: an exploration of stoma care in England
Authors: Bowles Theresa M , Moses Claire , Perry-Woodford Zarah L 
Published: September 2022

Background: This article is part one of a series presenting the findings of stakeholder surveys with ostomates and stoma care nurses for stoma services in England. Due to the volume of data and publication limits this article focuses on the views and experiences of 2504 people living with a stoma (ostomates). Aim: To understand the experience of ostomates in relation to the current services provided in hospital and at home, the delivery of care and views on areas that work well and areas that require improvement. Methods: Ostomates were asked to share their experiences in a national online survey, promoted via multiple organisations. The survey included sections for respondent demographics, interactions with the stoma care nurse (SCN), products and dispensing services, as well as patients' experiences relating to both hospital-based care and home-based care. Free-text responses relating to service delivery in hospital and at home were coded and thematically analysed. Findings: Results are presented, and verbatim quotes used to demonstrate themes. These include care provision and access to visits from the SCN, physical and psychological care, information sharing, specialist knowledge and products. Conclusion: Overall, the survey respondents praised the care given, however, the experiences and views shared via the survey show significant variation in the care and services received. This article presents the findings of a survey of ostomates living in England. A second article, presenting the findings about the experiences of stoma care nurses will be published in a forthcoming issue.
Quality-aware resource provisioning for multiband elastic optical networks: a deep-learning-assisted approach
Authors: Jana Rana Kumar , Chatterjee Bijoy Chand , Singh Abhishek Pratap , Srivastava Anand , Mukherjee Biswanath , Lord Andrew , Mitra Abhijit 
Published: September 2022

Multiband elastic optical network (MB-EON) technology can help to sustain exponential traffic growth in the optical backbone network. However, multiband operation creates high inter-channel stimulated Raman scattering, leading to a high nonlinear impairment (NLI) that may severely affect the optical signal-to-noise ratio (OSNR) of a lightpath. Additionally, the severity of NLI on the channel of interest depends upon the choice of allocated wavelength. Hence, appropriate channel allocation may cumulatively lead to a higher network capacity. This paper proposes a quality-aware resource provisioning scheme in the context of MB-EON that selectively chooses the available channels from different bands in order to achieve the maximum network capacity in the long run. A deep neural network-assisted quality of transmission estimator is considered to estimate the OSNR of a lightpath with accuracy of 99.65% and 0.012 dB variance in estimation error. The performance of our algorithm in the proposed scheme, namely, optical signal-to-noise ratio adaptive first–last-fit (OA-FLF), is analyzed for two geographically diverse networks, namely, BT-UK and the 24-node USA network, in terms of traffic admissibility, quality of established lightpaths, and contiguous aligned available slot ratio (CAASR), and compared with four state-of-the-art baseline algorithms: first fit, last fit, route adaptive first–last-fit, and distance adaptive first–last-fit. Numerical results indicate that the proposed algorithm outperforms all of the baseline algorithms in terms of traffic admissibility. Reported results show that, compared to the baseline algorithms, consideration of the effect of NLI before resource allocation in the OA-FLF algorithm can provide a maximum gain of nearly 30% in terms of traffic admissibility for smaller networks such as BT-UK, whereas, for longer geography such as the 24-node USA network, this traffic admissibility gain becomes close to 61% till 1% blocking.
GeO2-doped ring-core photonic crystal fiber for supporting robust orbital angular momentum modes
Authors: Zhou Jingmin , Xie Shuyang , Nie Chen , Li Lin , Shan Zhengping , Liu Exian 
Published: September 2022

Orbital angular momentum (OAM)-mode-supported photonic crystal fibers (PCFs) have inspired intensive research in modern fiber optics due to the robust propagation and theoretically unlimited signal-carried channels. In this paper, a dual-cladding

G
e
O

2

-doped ring-core PCF is designed, and a strategy for optimizing OAM mode properties is analyzed by structure parameters and

G
e
O

2

-doping concentration. Numeric results show that high structural degrees of freedom are available to improve the effective refractive index separation (within the vector modes), chromatic dispersion, effective mode field area, nonlinear coefficient, and OAM mode purity in terms of inner cladding, outer cladding, and ring-core. In particular, the effective refractive index separation and chromatic dispersion can exhibit a high order magnitude of

10

−
3

and a low value in the broad band from 1.3 µm to 1.7 µm, respectively. In addition to structural optimization, doping high index material into the ring-core is another way to regulate the fiber performance by controlling the doping concentration. A systematic investigation shows that as the doping concentration increases, the effective refractive index separation and mode purity increase obviously, while the dispersion and mode field area gradually decrease. This flexible manipulation offers a method for customizing the optical properties of OAM-supported PCFs in communication and sensor systems.
Polymorphisms of adiponectin gene and gene–lipid interaction with hypertension risk in Chinese coal miners: A matched case-control study
Authors: Hu Xiaoqin , Xi Yanfeng , Bai Wenqi , Zhang Zhenjun , Qi Jiahao , Dong Liang , Liang Huiting , Sun Zeyu , Lei Lijian , Fan Guoquan , Sun Chenming , Huo Cheng , Huang Jianjun , Wang Tong 
Published: September 2022

Objective
Low serum adiponectin level can predict hypertension development, and adiponectin gene (ADIPOQ) polymorphisms have been reported to be linked with hypertension risk. Whereas, the interaction between ADIPOQ polymorphisms and environmental factors on the susceptibility of hypertension remained unclear. The purpose of this study was to explore the relationship of ADIPOQ polymorphisms with hypertension risk and their interaction with lipid levels in coal miners.

Methods
A matched case-control study with 296 case-control pairs was performed in a large coal mining group located in North China. The participants were questioned by trained interviewers, and their ADIPOQ genotype and lipid levels were determined. Logistic regression, stratified analysis, and crossover analysis were applied to evaluate the effects of rs2241766, rs1501299, and rs266729 genotypes and gene–lipid interaction on hypertension risk.

Results
In this matched case-control study, the genotypes of rs2241766 TG+GG, rs1501299 GT+TT, and rs266729 CG+GG were marginally related to hypertension risk. Individuals with high total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) level were susceptible to hypertension (TC: odds ratio [OR] = 1.807, 95% confidence intervals [95%CI] = 1.266–2.581; LDL-C: OR = 1.981, 95%CI = 1.400–2.803; HDL-C: OR = 1.559, 95%CI = 1.093–2.223). Antagonistic interactions were detected between rs2241766 and TC, rs1501299 and TC, rs2241766 and LDL-C, and rs1501299 and HDL-C (rs2241766 and TC: OR = 0.393, 95%CI = 0.191–0.806; rs1501299 and TC: OR = 0.445, 95%CI = 0.216–0.918; rs2241766 and LDL-C: OR = 0.440, 95%CI = 0.221–0.877; rs1501299 and HDL-C: OR = 0.479, 95%CI = 0.237–0.967). Stratified analysis showed that hypertension risk was high for the subjects with rs2241766 TG+GG or rs1501299 GG under the low lipid level but low for those under the high lipid level. In the case group, the TC and LDL-C levels for rs2241766 TG+GG were lower than those for rs2241766 GG, and the TC and HDL-C levels for rs1501299 GT+TT were higher than those for rs1501299 GG.

Conclusions
Although the effects of ADIPOQ polymorphisms alone were not remarkable, an antagonistic interaction was observed between ADIPOQ polymorphisms and lipid levels.
Choriocapillaris flow deficit in a pachychoroid spectrum disease using en face optical coherence tomography angiography averaging
Authors: Tagawa Miho , Ooto Sotaro , Yamashiro Kenji , Tamura Hiroshi , Oishi Akio , Uji Akihito , Miyata Manabu , Miyake Masahiro , Takahashi Ayako , Ichioka Ai , Tsujikawa Akitaka 
Published: September 2022

Purpose
To investigate the choriocapillaris changes associated with pachychoroid pigment epitheliopathy (PPE) in comparison with healthy eyes.

Methods
Nine 3 × 3 mm macular optical coherence tomography angiography images were acquired in patients with PPE and age-matched healthy participants. Multiple en face image averaging of the choriocapillaris was binarized for quantitative image analysis of the flow voids. In PPE eyes, we evaluated the presence of pachyvessels and the association between the location of the choriocapillaris flow deficit and pachyvessels.

Results
Thirty-two eyes with PPE and 30 eyes of healthy participants were included. In PPE eyes, the mean total area (1.16 ± 0.18 vs. 0.91 ± 0.16, p < 0.001) and average size of the flow voids (790 ± 144 vs. 520 ± 138; p < 0.001) were significantly larger than those in control eyes. Composite images of the choriocapillaris and choroid showed choriocapillaris flow deficits just above and outside the pachyvessels. The mean proportion of the flow void area overlying the pachyvessels against the whole flow void area of the choriocapillaris was 21.3% ± 10.2% (9.38%-44.42%) in PPE eyes.

Conclusions
In PPE eyes, the blood flow area of the choriocapillaris decreased diffusely within the macular area compared to control eyes, and the choriocapillaris flow deficit was not necessarily related to pachyvessel location.
Time to diagnosis and treatment in younger adults with colorectal cancer: A systematic review
Authors: Castelo Matthew , Sue-Chue-Lam Colin , Paszat Lawrence , Kishibe Teruko , Scheer Adena S. , Hansen Bettina E. , Baxter Nancy N. 
Published: September 2022

Background
The incidence of colorectal cancer is rising in adults <50 years of age. As a primarily unscreened population, they may have clinically important delays to diagnosis and treatment. This study aimed to review the literature on delay intervals in patients <50 years with colorectal cancer (CRC), and explore associations between longer intervals and outcomes.

Methods
MEDLINE, Embase, and LILACS were searched until December 2, 2021. We included studies published after 1990 reporting any delay interval in adults <50 with CRC. Interval measures and associations with stage at presentation or survival were synthesized and described in a narrative fashion. Risk of bias was assessed using the Newcastle-Ottawa Scale, Institute of Health Economics Case Series Quality Appraisal Checklist, and the Aarhus Checklist for cancer delay studies.

Results
55 studies representing 188,530 younger CRC patients were included. Most studies used primary data collection (64%), and 47% reported a single center. Sixteen unique intervals were measured. The most common interval was symptom onset to diagnosis (21 studies; N = 2,107). By sample size, diagnosis to treatment start was the most reported interval (12 studies; N = 170,463). Four studies examined symptoms onset to treatment start (total interval). The shortest was a mean of 99.5 days and the longest was a median of 217 days. There was substantial heterogeneity in the measurement of intervals, and quality of reporting. Higher-quality studies were more likely to use cancer registries, and be population-based. In four studies reporting the relationship between intervals and cancer stage or survival, there were no clear associations between longer intervals and adverse outcomes.

Discussion
Adults <50 with CRC may have intervals between symptom onset to treatment start greater than 6 months. Studies reporting intervals among younger patients are limited by inconsistent results and heterogeneous reporting. There is insufficient evidence to determine if longer intervals are associated with advanced stage or worse survival.

Other
This study’s protocol was registered with the Prospective Register of Systematic Reviews (PROSPERO; registration number CRD42020179707).
Socially assistive robotics and older family caregivers of young adults with Intellectual and Developmental Disabilities (IDD): A pilot study exploring respite, acceptance, and usefulness
Authors: Xu Ling , Fields Noelle L. , Greer Julienne A. , Tamplain Priscila M. , Bricout John C. , Sharma Bonita , Doelling Kristen L. 
Published: September 2022

Introduction
The need for caregiver respite is well-documented for the care of persons with IDD. Social Assistive Robotics (SAR) offer promise in addressing the need for caregiver respite through ‘complementary caregiving’ activities that promote engagement and learning opportunities for a care recipient (CR) with IDD. This study explored the acceptability and usefulness of a SAR caregiver respite program responsive to feedback from both young adults with IDD and their older family caregivers (age 55+).

Method
Young adults with IDD and caregiver dyads (N = 11) were recruited. A mixed methods research design was deployed in three phases: Phase I with four focus groups to inform the program design; Phase II for program demonstration and evaluation with pre- and post-surveys; and Phase III with post-program interviews for feedback and suggestions.

Results
Both young adults with IDD and their caregivers scored favorably the social presence of, social engagement, and satisfaction with robot Pepper. Though there was no significant improvement of caregiving burden/stress as well as well-being of the young adults with IDD based on surveys, results from interviews suggested that the SAR may offer physical/emotional respite to caregivers by providing companionship/friendship as well as promoting independence, safety/monitoring, and interactive engagement with children.

Discussion
SAR has potential in providing respite for older family caregivers. Future studies need a longer program design and larger sample size to develop a promising intervention and test its feasibility and efficacy.