bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Parboiling on the Physicochemical and Phytochemicals Characteristics of Traditional Rice Cultivars
Authors: Sri M.J. Anitha , Kanchana S. , Geetha P.S. , Mini M.L. , Vanniyarajan C. , Ejilane J. , Pasupathi E. 
Published: October 2022

Background: The indigenous rice varieties of India are cultivated and utilized by tribal peoples as well as people in the distant regions with traditional culture. The main aim of the research work was to explore the inherit beneficial characteristics of traditional rice cultivars over hybrid varieties. Methods: The research work was aimed to investiagate the physicochemical and phytochemicals characteristics in traditional red rice cultivars (Mapillai Samba and Karungkuruvai) and traditional white rice cultivars (IR 20 and Improved White Ponni). The different treatments used in the study were raw rice (unpolished, polished) and parboiled rice (unpolished, polished). The interaction between physicochemical characteristics and phytochemicals were evaluated using Pearson correlation and Principal component analysis. Result: The physicochemical characteristics were analyzed for all the rice cultivars. It was observed that parboiled-unpolished mapillai samba showed highest length, breadth, 1000 grain weight. The raw rice cultivars showed highest phytochemicals than parboiled rice. The total phenolic, total flavonoids and total anthocyanin contents were highest for the mapillai samba (raw rice-unpolished). Among different traditional rice cultivars, mapillai samba showed significantly higher antioxidant levels. The results of the study suggested that these traditional rice cultivars can be incorporated in value added products.
Thoughts of Bangabandhu Sheikh Mujibur Rahman on agricultural and industrial development in Bangladesh: An analysis
Authors: Billah Arif 
Published: October 2022

Bangabandhu Sheikh Mujibur Rahman is one of the most undeniable and charismatic leaders in the world. He won the trust, support and hope of the general public as a result of his inherent and exceptional traits (East Bengalis). The purpose of this study is to examine the important roles he has played in boosting Bangladesh's economy. Secondary data was acquired from a range of sources, including journals, websites, articles and books, as well as descriptive and preferred qualitative approaches, and national and international media. Government documents, research papers and publications from international organisations, research institutes and individual academics were examined. Bangladesh has become a global role model for sustainable development in addition to achieving food security, thanks to its energetic efforts and future recommendations (1972–1975). Bangladesh is progressing quickly because of its ideologies and ideals. Bangladesh is on track to becoming a developed country by 2041, thanks to its ideologies and ideals.

Keywords: Agriculture, Bangabandhu, Bangladesh, development, economic;
The effects of foreign direct investment and trade openness on economic growth amid crises in Asian economies
Authors: Hossain Rabiul 
Published: October 2022

Purpose ― The main objective is to examine the effects of foreign direct investment and trade openness on economic growth (SDG-8.1) about economic growth amid crises in 30 Asian economies.
Design/methodology/approach ― The effects of FDI and trade openness on economic growth in the Asian region are examined using the fixed-effects model, panel corrected standard errors (PCSE), and generalized method of moments (GMM) estimations. The study also measures the long-run effects of the estimates and the granger causality tests.
Findings ― The findings revealed that both FDI and trade openness contribute to boosting economic growth in Asian economies, and the effect is also persistent in the long run. We also find that the Asian and global financial collapse shocks in 1997-1998 and 2008-2009, respectively, adversely affected the region's economic growth. Additionally, the economic growths of some Asian countries are below the targeted level set in SDG-8.1.
Practical implications ― The Asian countries should adopt appropriate policy measures for encouraging the inflow of FDI and cross-border trade of goods and services as it is evident that the inflow of FDI and open trade will improve local human capital and technological capabilities of the industries, which will ultimately help to enhance stable economic growth.
Originality/value ― This study is unique in accompanying the Asian financial crisis and world recession in studying the effects of FDI and trade openness on SDG-8.1 in Asian economies.
PROTOTIPE SMART REAL TIME ALARM BERBASIS ARDUINO MEGA 2560 DI RUANGAN ORGANISASI KEMAHASISWAAN
Authors: Eka Rahmah Pratiwi Adinda , Fahmy Resmont , Yusro Muhammad 
Published: October 2022

The purpose of this thesis is to make a prototype realtime alarm in the student organization room as a reminder of the lecture schedule to be more efficient and for access in and out of the members' room as a safety. The method used in this research is the experimental method. This experimental research was conducted in system design, both in hardware design and software design of this device. This prototype diagram consists of an input block diagram that containing a fingerprint sensor and an RTC module, block diagram control set by Arduino Mega 2560, and output block diagrams containing LCD, solenoid, dfplayer, servo motor, relay and speaker. Test results that the author has done, this prototype has been running in accordance with the program created. The results obtained are fingerprint sensors can detect fingerprints of members when entering or exiting. When members enter or exit, the solenoid will open the door lock and the servo motor will open the door. Then the alarm will activate and make a sound from the speaker 10 minutes before the lecture schedule. This system will work repeatedly until the system is turned off.
Tujuan penelitian ini adalah membuat prototipe real time alarm di ruangan organisasi kemahasiswaan sebagai pengingat jadwal jam perkuliahan agar lebih efisien serta untuk akses masuk dan keluar ruangan anggota sebagai pengaman. Metode yang digunakan dalam penelitian ini adalah metode eksperimen (uji coba). Penelitian eksperimen ini dilakukan pada perancangan sistem, baik pada perancangan perangkat keras (hardware) maupun perancangan perangkat lunak (software) dari alat ini. Diagram prototipe ini terdiri dari blok diagram input yang berisi sensor fingerprint dan modul RTC, blok diagram kontrol yang diatur oleh Arduino Mega 2560, serta blok diagram output yang berisi LCD, solenoid, dfplayer, motor servo, relay dan speaker. Hasil pengujian yang telah penulis lakukan, prototipe ini telah berjalan sesuai dengan program yang di buat. Hasil yang didapat adalah fingerprint dapat mendeteksi sidik jari anggota pada saat masuk atau keluar. Pada saat anggota masuk atau keluar solenoid akan membuka kunci pintu lalu motor servo akan membuka pintu. Kemudian alarm akan aktif dan mengeluarkan suara dari speaker saat 10 menit sebelum jadwal perkuliahan anggota. Sistem ini akan bekerja terus berulang hingga sistem dimatikan.
KELAYAKAN MODUL PEMILIHAN BAHAN BUSANA PENGANTIN PADA MATA KULIAH BUSANA WANITA 3
Authors: Suci Amalia  , Suryawati Suryawati , Rawiyah Lubis Harsuyanti 
Published: October 2022

Penelitian ini bertujuan untuk penilaian kelayakan bahan pembelajaran berbentuk modul dengan materi bahan busana pengantin dalam mata kuliah busana wanita 3. Metode yang digunakan dalam penelitian ini adalah metode Pre-Experimental dengan desain One-Shot Case Study. Teknik analisis data yang digunakan Kuantitatif Deskriptif. Menggunakan variabel tunggal yaitu variabel bahan ajar modul Busana Wanita 3 Materi Bahan Busana Pengantin. Penelitian ini menggunakan indikator penilaian bahan ajar dengan aspek materi, aspek penyajian, dan kebahasaan, dan berdasarkan 5 karakteristik modul yaitu pembelajaran diri (self-instruction), satu kesatuan (self-contained), berdiri sendiri (stand alone), menyesuaikan diri (adaptive), dan mudah digunakan (user friendly). Hasil penelitian menyatakan bahwa modul pembelajaran Busana Wanita 3 Materi Bahan Busana Pengantin dengan memperoleh persentase rata-rata 82,5% sebagai bahan ajar modul. Penilaian berdasarkan nilai tertinggi aspek bahan ajar, pada aspek materi dengan persentase 80% karena aspek materi modul Busana Wanita 3 tersusun sistematis sesuai dengan acuan Rencana Pembelajaran Semester (RPS). Aspek media dengan penilaian tertinggi didapatkan pada aspek User Friendly dengan persentase 94% , karena aspek media disusun dengan bahasa yang komunikatif sehingga bagi pengguna mudah dipahami. Penilaian berdasarkan nilai terendah dalam aspek bahan ajar, pada aspek kebahasan dengan persentase 75%. Nilai terendah pada aspek media terdapat pada aspek satu kesatuan (Self Contained), persentase 75%.
Inhibitory action of mVOCs from Shewanella algae Sg8 against phytopathogenic fungi and transcriptional elicitation of PR genes in tomato
Authors: Subramanian Radhesh Krishnan , Kumaravel Sengali Ragunath , Sriniva Radhakrishnan , Prabakaran Narayanasamy , Kandasamy Keerthana Ponni , G Balaji , K Latha 
Published: October 2022

Abstract
The analysis of Microbial volatile organic compounds (mVOCs) is an emerging research field with huge impact in the fields of medical and agricultural biotechnology, mVOCs are being considered as imminent eco-friendly alternatives to chemical pesticides and fertilizers in sustainable agriculture. In this study, we characterized the effect of volatiles emitted from Shewanella algae (Sg8) isolated from a marine ecosystem in promoting plant growth, in controlling the activity of Fusarium oxysporum and its antagonistic activity against other phytopathogenic fungus. Sg8 inhibited the growth of four other agronomically important foliar and soil plant pathogens: Botrytis cinerea, Colletotrichum gloeosporioides, Magnoporthae oryzae and Macrophomina sp. The effect of mVOCs produced by the bacterium Sg8, on plant growth were investigated on tomato plants under in vivo conditions. The VOCs emitted from Sg8 up regulated the Thaumatin-like antifungal (PR-5) gene (9-fold) and Glutamine synthetase (GS) gene (0.96-fold) in tomato plants. Sg8 effectively inhibited the growth of F. oxysporum and possessed plant growth promoting (PGP) activity. Our results show that Sg8 generates bioactive volatiles that induces the regulation of Pathogenesis related (PR) genes, and stimulates the growth of the plants and also suppresses the growth of other agriculturally important foliar and soil phyto-pathogenic fungus.
Comparison between Oblique Lateral Interbody Fusion and Minimally Invasive Transforaminal Lumbar Interbody Fusion in Degenerative Lumbar Stenosis: An Age-, Sex-, and Segment-matched Cohort Study
Authors: Liu Lantao , Xue Hui , Han Zhiyuan , Jiang Lianghai , Chen Longwei , Wang Dechun 
Published: October 2022

Abstract
Objectives: To compare outcomes after oblique lateral interbody fusion (OLIF) versus minimally invasive transforaminal lumbar interbody fusion (MISTLIF) with bilateral decompression via unilateral approach for treating mild to moderate symptomatic degenerative lumbar spinal stenosis (DLSS).
Methods: We retrospectively compared patients who underwent single-level (L4/5) OLIF with an age-, sex-, and segment-matched MISTLIF with bilateral decompression via unilateral approach cohort. Perioperative data were collected for the operative time, intraoperative blood loss, drainage in the first postoperative day, postoperative hospital stay, cost, intraoperative fluoroscopy, and complications. Lumbar radiographs were measured for changes in posterior intervertebral space height (PISH), intervertebral space foramen height (IFH), intervertebral foramen area (IFA), and area of the spinal canal (ASC). Clinical and psychological outcomes included the visual analog scale (VAS), Oswestry Disability Index (ODI), and hospital anxiety and depression scale (HADS).
Results: 35 OLIF patients were compared with 35 MISTLIF patients in L4/5 DLSS. The OLIF group had shorter bedtime, postoperative hospital stays, less intraoperative and postoperative blood loss (all P<0.05), but had more times of intraoperative fluoroscopy, longer operative time, and higher cost (all P<0.05). The complication rates were equivalent (OLIF vs MISTLIF: 22.86% vs 17.14%). PISH (11.94±1.78mm vs 9.42±1.94mm, P<0.05), IFH (23.87±3.05mm vs 21.41±2.95mm, P<0.05), and IFA (212.14±51.82mm2 vs 177.07±51.73mm2, P<0.05) after surgery were significantly increased in the OLIF group. The ASC was increased significantly after the operation in both groups, but the ASC in the MISTLIF group was increased significantly more than that in the OLIF group (450.04±66.66mm2 vs 171.41±58.55mm2, P<0.05). The lumbar VAS scores at 1 month (1.89±0.87 vs 2.34±0.84, P=0.028) and 6 months (1.23±0.97 vs 1.80±0.99, P=0.018) after operation in the OLIF group were significantly lower. There were no significant differences in lower extremity VAS and ODI scores between the two groups. Compared with MISTLIF group, HADS scores on postoperative day 3 (2.91±1.46 vs 4.89±1.78, P<0.05) and prior to hospital discharge (PTD) (2.54±1.38 vs 3.80±1.78, P=0.002) in the OLIF group were decreased significantly.
Conclusions: OLIF showed more advantages of less surgical invasion, lower incidence of postoperative low back pain, faster postoperative recovery, and less anxiety compared with MISTLIF. Regardless of cost, OLIF seems to be a better option to treat mild to moderate symptomatic DLSS.
Thermodynamic Parameters of Phenylglycine Interaction with UO22+, La3+ and Zr4+
Authors: El-Dossoki Farid I. , Mohamed Abd Allah Abd El-Wahab 
Published: October 2022

Abstract
The interactions between phenylglycine and some transition metal ions (UO22+,La3+ and Zr4+) were studied at three ionic strengths [(µ = 0.05, 0.10 and 0.15) M KNO3] and three temperatures [(25, 35 and 45) ºC] in aqueous media by using Bjerrum’s potentiometric technique. The stoichiometric and thermodynamic stability constants as well as the degree of complexation for all studied systems (\(\stackrel{-}{\text{n}}\)) were determined and discussed. The standard thermodynamic parameters (Δ pKº and Δlog Kº) and the thermodynamic parameter differences (ΔGº, ΔΔGº, ΔHº, ΔΔHº, ΔSº, and ΔΔSº) were calculated for all possible reactions. Advanced discussions of these functions as well as the factors that may control the complexation processes from the thermodynamic point of view have been reported.
Push-pull behavior of 2,7-disubstituted sila- and germafluorenes
Authors: Jarrett-Noland Shelby J. , McConnell William , Braddock-Wilking Janet , Dupureur Cynthia M. 
Published: October 2022

Abstract
Push-pull dyes exhibit intramolecular charge transfer behavior, which due to changes in dipole moment upon excitation, is the origin of their environmental sensitivity. Such compounds are of interest as probes for bioimaging and as biosensors to monitor cellular dynamics and molecular interactions. Desirable biological probes absorb in the visible region, have high extinction coefficients, high quantum yields and excellent photostability. Fluorophores with scaffolding that can be used to tune and optimize solvatochromic behavior are of particular interest. Here we investigate the environmental sensitivity of a small library of highly fluorescent 2,7-disubstituted sila- and germafluorenes. Density functional theory calculations show that charge transfer occurs from the alkyne core out to the 2,7- and 3,6-methoxy substituents, the hallmark of push-pull behavior. They exhibit HOMO-LUMO energy gaps of about 3 eV with dipole moments ranging from 2-3.25 D. These compounds exhibit desirable Stokes shifts in various solvents, and the dependences of Stokes shift on solvent polarizability are consistent with solvatochromic behavior. With the ability to tune push-pull properties via the 2,7-substituent, these disubstituted sila- and germafluorenes have excellent potential as biological probes.
Structure of a duplex-embedded G-quadruplex system resolved to 7.4 Å resolution by cryo-EM
Authors: Monsen Robert , Chua Eugene , Hopkins Jesse , Chaires Jonathan , Trent John 
Published: October 2022

Abstract
Genomic regions with high guanine content can fold into non-B form DNA four-stranded structures known as G-quadruplexes (G4s). Extensive in vivo investigations have revealed that promoter G4s are transcriptional regulators. Little structural information exists for these G4s embedded within duplexes, their presumed genomic environment. Here we report the 7.4 Å resolution structure and dynamics of a 28.5 kDa duplex-G4-duplex (DGD) model system using cryo-EM, molecular dynamics, and small-angle X-ray scattering (SAXS) studies. The DGD cryo-EM refined model features a 53° bend induced by a stacked duplex-G4 interaction at the 5’ G-tetrad interface with a persistently unstacked 3’ duplex. The surrogate complement poly dT loop preferably stacks onto the 3’ G-tetrad interface resulting in occlusion of both 5’ and 3’ tetrad interfaces. Structural analysis shows that the DGD model is quantifiably more druggable than the monomeric G4 structure alone and represents a new structural drug target. Our results illustrate how the integration of cryo-EM, MD, and SAXS can reveal complementary detailed static and dynamic structural information on DNA G4 systems.
Transcriptional regulation profiling reveals PPARA-mediated fatty acid oxidation as a novel therapeutic target in phospholamban R14del cardiomyopathy
Authors: Harakalova Magdalena , Pei Jiayi , Maas Renee , Gaar-Humphreys Karen , Gho Johannes , Nagyova Emilia , Blok Christian Snijders , Adrichem Iris van , Es René van , Sepehrkhouy Shahrzad , Feyen Dries , Dungen Noortje van den , Lansu Nico , Calis Jorg , Kaaij Niels van der , de Jonge Nicolaas , Laake Linda van , Riele Anneline ter , Huibers Manon , de Weger Roel , Verhaar Marianne C. , Tintelen J. Peter van , Vaz Frederic , Burgering Boudewijn , Mil Alain van , Buikema Jan , Vink Aryan , Karakikes Ioannis , Mercola Mark , Doevendans Pieter AFM , Sluijter Joost , Steenbeek Frank van , Cheng Caroline , Mokry Michal , Asselbergs Folkert 
Published: October 2022

Abstract

Carriers of the R14del pathogenic variant in the phospholamban (PLN) gene develop severe cardiomyopathy with extracellular adipocyte infiltration and intracellular cardiomyocyte mitochondrial disturbances. However, the basis of this metabolic dysregulation tailoring potential treatment targets is unknown. Here, we present a combined approach of transcriptional regulation analysis in human primary tissue and validation in a unique long-term (160 days) matured human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) model. We demonstrate a dysregulated PPARA-mediated mitochondrial fatty acid oxidation (FAO) signalling in PLN-R14del hearts and hiPSC-CMs. PLN-R14del hiPSC-CMs also displayed a higher preference for glycolysis over FAO and presented limited flexibility in energy substrate switching leading to enhanced lipid droplet storage. By activating PPARA in PLN-R14del hiPSC-CMs using bezafibrate, we observed an improved mitochondrial structure and calcium handling function, further indicating the importance of FAO in the disease and the potential of PPARA agonists as a novel therapeutic strategy in cardiomyopathies.
Epidemiology of hand, foot, and mouth disease and genetic characteristics of Coxsackievirus A10 in Taiyuan City, Shanxi Province from 2016–2020
Authors: Wang Jitao , Liu Hongyan , Cao Zijun , Xu Jihong , Guo Jiane , Zhao Lifeng , Wang Rui , Xu Yang , Gao Ruihong , Gao Li , Zuo Zhihong , Xiao Jinbo , Lu Huanhuan , Zhang Yong 
Published: October 2022

Abstract

Background In recent years, the prevalence of hand, foot, and mouth disease (HFMD) caused by enteroviruses other than enterovirus A71 (EV-A71) and coxsackievirus A16 (CVA16) has gradually increased. The pathogen spectrum of HFMD also continues to change. In this study, we analyzed the epidemiological characteristics of HFMD and the genetic characteristics of the coxsackievirus A10 (CVA10) virus identified in Taiyuan City, Shanxi Province. Methods The epidemiological data from 2016–2020 on HFMD in Taiyuan City was collected from the China Information System For Disease Control and Prevention. The throat swab specimens of 2701 HFMD cases were tested, theVP1regions of CVA10 RNA were amplified using RT-PCR, and phylogenetic analysis of CVA10 was performed. The study results were analyzed using Pearson's Chi-Square Test. Results Children aged 1–5 years accounted for the majority (81.65%) of all HFMD cases, and the average annual incidence is higher in boys than in girls. Of the 2,701 specimens collected, 1,439 (53.28%) were positive for human enterovirus (EV). The positivity rates of EV-A71, CVA16, and other EVs were 15.22% (219/1439), 28.77% (414/1439), and 56.01% (806/1439), respectively. The proportion of specimens positive for other EVs was significantly higher than that of EV-A71 and CVA16. CVA10 is one of the important viruses of other EVs. A total of 52 CVA10 strains were used for phylogenetic analysis based on theVP1region. Of the 52 CVA10 strains, 31 were from this study, and 21 were downloaded from GenBank. All CVA10 sequences could be assigned to seven genotypes (A, B, C, D, E, F, and G), and genotype C was further divided into C1 and C2 subtypes. Of the 31 CVA10 strains identified in this study, only one belonged to subtype C1 and the remaining 30 belonged to C2. Conclusions This study emphasized the importance of strengthening the surveillance of the HFMD in order to understand the mechanisms of pathogen variation and evolution, so as to provide a scientific basis for HFMD prevention, control, and vaccine development.
BuYangHuanWu decoction alleviates atherosclerosis by regulating intestinal microbiota and metabolites in ApoE-/- mice fed with HFD
Authors: Yu Qun , Zhang Yilin , Zeng Wenyun , Sun Yingxin , Zeng Miao , Yang Qiuyue , Guo Lin , Zhang Xiaolu , Zhang Yue , Yu Bin , Guo Maojuan , Wang Yu , Li Huhu , Suo Yanrong , Jiang Xijuan , Song Lili 
Published: October 2022

Abstract

Background Traditional Chinese herbal prescription BuYangHuanWu decoction (BHD) works well in treating atherosclerosis. However, the mechanism of BHD in atherosclerosis has not been fully elucidated. We aimed to determine whether BHD could alleviate atherosclerosis by altering the microbiome-associated metabolic changes in atherosclerotic mice. Methods An atherosclerotic model was induced in ApoE−/−mice fed a high-fat diet (HFD), and BHD were administered by gavage for 12 weeks at 8.4g/kg/d and 16.8g/kg/d. Atherosclerotic plaque size, composition, serum lipid profile, as well as inflammatory cytokines were assessed. Mechanistically, metabolomic and micro biota profiling were analyzed using liquid chromatography mass spectrometry (LC-MS) and 16S rRNA gene sequencing, respectively. Further, intestinal microbiota and atherosclerosis-related metabolic parameters were correlated using Spearman analysis. Results Atherosclerotic mice treated with BHD showed a reduction in plaque area, aortic lumen occlusion, and lipid accumulation in the aortic root. 9 perturbed serum metabolites were significantly restored along with the relative abundance of micro biota at the family and genus levels, but not at the phylum level. Gut microbiota improvements were strongly negatively correlated with improved metabolite levels. Conclusions BHD treatment effectively slows the progression of atherosclerosis by regulating altered intestinal microbiota and perturbed metabolites. Detailed analysis of these interactions between intestinal microbes and metabolites affected by BHD will help in the development of new anti-atherosclerosis medications.