bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bathyal octopus, Muusoctopus leioderma, living in a world of acid: First recordings of routine metabolic rate and critical oxygen partial pressures of a deep water species under elevated pCO2
Authors: Trueblood Lloyd A. , Onthank Kirt , Bos Noah , Buller Lucas , Coast Arianna , Covrig Michael , Edwards Ethan , Fratianni Stefano , Gano Matthew , Iwakoshi Nathaniel , Kim Eden , Moss Kyle , Personius Chantel , Reynoso Stephanie , Springbett Cheyne 
Published: December 2022

Elevated atmospheric CO2 as a result of human activity is dissolving into the world’s oceans, driving a drop in pH, and making them more acidic. Here we present the first data on the impacts of ocean acidification on a bathyal species of octopus Muusoctopus leioderma. A recent discovery of a shallow living population in the Salish Sea, Washington United States allowed collection via SCUBA and maintenance in the lab. We exposed individual Muusoctopus leioderma to elevated CO2 pressure (pCO2) for 1 day and 7 days, measuring their routine metabolic rate (RMR), critical partial pressure (Pcrit), and oxygen supply capacity (α). At the time of this writing, we believe this is the first aerobic metabolic data recorded for a member of Muusoctopus. Our results showed that there was no change in either RMR, Pcrit or α at 1800 µatm compared to the 1,000 µatm of the habitat where this population was collected. The ability to maintain aerobic physiology at these relatively high levels is discussed and considered against phylogeny and life history.
Evolutionary analyses and expression patterns of TCP genes in Ranunculales
Authors: Damerval Catherine , Claudot Carmine , Le Guilloux Martine , Conde e Silva Natalia , Brunaud Véronique , Soubigou-Taconnat Ludivine , Caius José , Delannoy Etienne , Nadot Sophie , Jabbour Florian , Deveaux Yves 
Published: December 2022

TCP transcription factors play a role in a large number of developmental processes and are at the crossroads of numerous hormonal biosynthetic and signaling pathways. The complete repertoire of TCP genes has already been characterized in several plant species, but not in any species of early diverging eudicots. We focused on the order Ranunculales because of its phylogenetic position as sister group to all other eudicots and its important morphological diversity. Results show that all the TCP genes expressed in the floral transcriptome of Nigella damascena (Ranunculaceae) are the orthologs of the TCP genes previously identified from the fully sequenced genome of Aquilegia coerulea. Phylogenetic analyses combined with the identification of conserved amino acid motifs suggest that six paralogous genes of class I TCP transcription factors were present in the common ancestor of angiosperms. We highlight independent duplications in core eudicots and Ranunculales within the class I and class II subfamilies, resulting in different numbers of paralogs within the main subclasses of TCP genes. This has most probably major consequences on the functional diversification of these genes in different plant clades. The expression patterns of TCP genes in Nigella damascena were consistent with the general suggestion that CIN and class I TCP genes may have redundant roles or take part in same pathways, while CYC/TB1 genes have more specific actions. Our findings open the way for future studies at the tissue level, and for investigating redundancy and subfunctionalisation in TCP genes and their role in the evolution of morphological novelties.
Psychometric properties and construct validity of the Parkinson’s Disease-Cognitive Rating Scale (PD-CRS) in Colombia
Authors: Clavijo-Moran Hugo Juan Camilo , Álvarez-García Daniela , Pinilla-Monsalve Gabriel D. , Muñoz-Ospina Beatriz , Orozco Jorge 
Published: December 2022

BackgroundCognitive impairment is frequent among people living with Parkinson’s disease: up to 40% of patients exhibit symptoms of mild cognitive impairment and 25% meet the criteria for dementia. Parkinson’s Disease Cognitive Rating Scale (PD-CRS) is one of the recommended scales by the Movement Disorders Society Task Force for level 1 screening of dementia. However, its psychometric properties have not been studied in the Colombian population.MethodsA cross-sectional study was conducted on 100 patients with Parkinson’s disease diagnosed by a movement disorders neurologist. Patients were evaluated with PD-CRS and MoCA. Principal component analysis was conducted, and then confirmatory factor analysis was implemented through the maximum-likelihood method. Internal consistency was evaluated using Cronbach α. Convergent and divergent validity were also calculated and concurrent validity with the MoCA was assessed.Results62% were males. Their median age was 68 years (IQR 57–74) and the median disease duration was 4 years (IQR 2–9). 77% were classified in early stages (Hoehn and Yahr stage ≤ 2), while the MDS-UPDRS part III score was 25 (IQR 15.5–38). In the principal component factor analysis, the pattern matrix unveiled a mnesic and a non-mnesic domain. Confirmatory factor analysis showed similar explanatory capacity (λ ≥ 0.50) for items other than naming (λ = 0.34). Cronbach’s α for the full 9-items instrument was 0.74. MoCA and PD-CRS total scores were correlated (ρ = 0.71, p = 0.000). Assuming a cut-off score of 62 points, there is an agreement of 89% with the definition of dementia by MoCA for Colombia (κ = 0.59; p = 0.000).ConclusionPD-CRS has acceptable psychometric properties for the Colombian population and has significant correlation and agreement with a validated scale (MoCA).
Organization measures in the Enhanced Baking Tray Task
Authors: Argiuolo Antonietta , Somma Federica , Bartolomeo Paolo , Gigliotta Onofrio , Ponticorvo Michela 
Published: December 2022

IntroductionThe ecological assessment and the analysis of spatial organization behaviors, like the organization of objects in an empty space, in clinical and neurotypical conditions, is crucial. The Enhanced-Baking Tray Task (E-BTT) is as simple as that – placing objects inside a frame as evenly as possible, as if they were “cookies” to be baked in the oven. The E-BTT is the enhanced version of a task for neglect assessment, the Baking Tray Task, and has the advantage to register the coordinates of each object and their temporal order, meaning that it is easy to reconstruct the sequence of their placement. This sequence could be further analyzed, and, in this paper, we aim to do that with a series of indexes. Moreover, since they investigate the visual search organization of the sequence itself, their validity will be tested with a convergent measure of subjective organization.MethodsTherefore, we asked 100 observers (76 women) to evaluate the subjective organization of each of 97 E-BTT plots, on a scale that ranged from 0 = not at all to 100 = well organized.ResultsA multiple regression model showed a significant association between subjective organization ratings (dependent variable) and Intersection rate, Total time of performance and distance to both optimal sequences (independent variables).DiscussionTherefore the above-mentioned indexes can be considered measures of the overall organization in the E-BTT.
Memory matching features bias the ensemble perception of facial identity
Authors: Pan Tingting , Zheng Zheng , Li Feiming , Wang Jun 
Published: December 2022

IntroductionHumans have the ability to efficiently extract summary statistics (i.e., mean) from a group of similar objects, referred to as ensemble coding. Recent studies have demonstrated that ensemble perception of simple objects is modulated by the visual working memory (VWM) task through matching features in VWM. However, few studies have examined the extending scope of such a matching feature effect and the influence of the organization mode (i.e., the way of combining memory matching features with ensemble properties) on this effect. Two experiments were done to explore these questions.MethodsWe used a dual-task paradigm for both experiments, which included a VWM task and a mean estimation task. Participants were required to adjust a test face to the mean identity face and report whether the irregular objects in a memory probe were identical or different to the studied objects. In Experiment 1, using identity faces as ensemble stimuli, we compared participants’ performances in trials where a subset color matched that of the studied objects to those of trials without color-matching subsets. In Experiment 2, we combined memory matching colors with ensemble properties in common region cues and compared the effect with that of Experiment 1.ResultsResults of Experiments 1 and 2 showed an effect of the VWM task on high-level ensemble perception that was similar to previous studies using a low-level averaging task. However, the combined analysis of Experiments 1 and 2 revealed that memory matching features had less influence on mean estimations when matching features and ensemble properties combined in the common region than when combined as parts of a complete unit.ConclusionThese findings suggest that the impact of memory matching features is not limited by the level of stimulus feature, but can be impacted by the organization between matching features and ensemble target properties.
COVID-19 related stress during and one year after the first wave of the pandemic outbreak in China: The role of social support and perceptions of the pandemic
Authors: Hu Jingchu , Liu Jiayu , Huang Yiting , Zheng Zhiying , Yang Dongliang , Zhou Yunfei , Wang Jianhong 
Published: December 2022

IntroductionCOVID-19 related stress might vary with the pandemic changes, as well as other associated factors. This study aimed to compare the stress level during the first wave of the pandemic outbreak and 1 year later in China, and to explore the differential roles of social support and perceptions of this disease in affecting pandemic-related stress over time.MethodsCOVID-19 related stress, social support, and perceptions of the pandemic (perceived threat, perceived protection, and perceived controllability) were measured using the Impact of Event Scale-Revised for COVID-19, the Multidimensional Scale of Perceived Social Support, and the Self-Compiled Scale of COVID-19 Related Perception, respectively. Using an online survey, two independent samples were collected during the first wave of the COVID-19 outbreak (Time 1: March 2020, N = 430) and 1 year later (Time 2: April 2021, N = 512).ResultsLevels of COVID-19 related stress and social support were lower at Time 2. Furthermore, at both Time 1 and Time 2, more social support was associated with less stress. Perceived protection and controllability of COVID-19 also mediated the relationship between social support and COVID-19 at both time points. However, the perceived threat of COVID-19 only served as a mediator at Time 1.ConclusionThese results indicate that Chinese people might experience lower COVID-19 related stress as the pandemic progresses. The perceived threat of COVID-19 played a more critical role in stress experienced at Time 1. These findings not only underscore the importance of social support under the context of Chinese society, but also have implications for developing specific interventions targeting different perceptions of COVID-19 to reduce pandemic-related stress during the different waves of this pandemic.
Patient with bipolar I disorder who presented with low blood lithium levels after receiving crushed tablets via a nasogastric tube: A case report
Authors: Fujikawa Ryoko , Fujii Kumiko , Ozeki Yuji 
Published: December 2022

In clinical psychiatric cases, the placement of a nasogastric tube is occasionally considered. If a patient who presents with mania or other psychiatric conditions refuses to take drugs, they are administered via the nasogastric tube. The tablet is crushed, suspended, passed via the nasogastric line, and reaches the stomach directly. However, the effects of these processes on blood drug concentrations remain unclear. Herein, we report a patient with bipolar I disorder who presented with low blood lithium carbonate (Li) concentrations after receiving the drug via the nasogastric tube.CaseA 26-year-old woman developed manic symptoms with grandeur delusion. She was admitted to a psychiatric hospital three times after diagnosis. Her manic symptoms with delusion improved with Li and aripiprazole (ARP). Her condition stabilized with Li 800 mg/day and ARP 9 mg/day. After the Li dose was reduced to 600 mg/day, she maintained remission, with the blood level range of Li being 0.31 ∼ 0.42 mEq/L. After 1 year, she was admitted to our hospital due to a jaw deformity. During the perioperative period, treatment with oral Li was discontinued by the surgeons, and her manic symptoms recurred. During therapy with olanzapine 20 mg and Li 800 mg, her blood Li concentration was 0.67 mEq/L. The symptoms remained. Hence, the Li dose increased to 1,000 mg/day. However, she refused to take the medication. Thus, a nasogastric tube was used to administer medicines. Thereafter, the blood Li concentration decreased to 0.43 mEq/L, which was lesser than 800 mg/day. Each blood sample was collected approximately 18 h after the administration. Her symptoms remained. Thereafter, she agreed to take the medication, and the Li concentration reached 0.78 mEq/L. Then, the symptoms partly improved.ConclusionAfter the administration of Li via the nasogastric tube, the Li concentration decreased, which was lower than expected. This phenomenon could be attributed to the fact that the medication was crushed, suspended, and administered via the nasogastric tube. Therefore, pulverizing and administering Li tablets via the nasogastric tube can be applied for the management of mania, however, caution should be observed because of the risk of fluctuations in blood Li levels, as in this case.
Detection of SARS-CoV-2 infection clusters: The useful combination of spatiotemporal clustering and genomic analyses
Authors: Choi Yangji , Ladoy Anaïs , De Ridder David , Jacot Damien , Vuilleumier Séverine , Bertelli Claire , Guessous Idris , Pillonel Trestan , Joost Stéphane , Greub Gilbert 
Published: December 2022

BackgroundThe need for effective public health surveillance systems to track virus spread for targeted interventions was highlighted during the COVID-19 pandemic. It spurred an interest in the use of spatiotemporal clustering and genomic analyses to identify high-risk areas and track the spread of the SARS-CoV-2 virus. However, these two approaches are rarely combined in surveillance systems to complement each one's limitations; spatiotemporal clustering approaches usually consider only one source of virus transmission (i.e., the residential setting) to detect case clusters, while genomic studies require significant resources and processing time that can delay decision-making. Here, we clarify the differences and possible synergies of these two approaches in the context of infectious disease surveillance systems by investigating to what extent geographically-defined clusters are confirmed as transmission clusters based on genome sequences, and how genomic-based analyses can improve the epidemiological investigations associated with spatiotemporal cluster detection.MethodsFor this purpose, we sequenced the SARS-CoV-2 genomes of 172 cases that were part of a collection of spatiotemporal clusters found in a Swiss state (Vaud) during the first epidemic wave. We subsequently examined intra-cluster genetic similarities and spatiotemporal distributions across virus genotypes.ResultsOur results suggest that the congruence between the two approaches might depend on geographic features of the area (rural/urban) and epidemic context (e.g., lockdown). We also identified two potential superspreading events that started from cases in the main urban area of the state, leading to smaller spreading events in neighboring regions, as well as a large spreading in a geographically-isolated area. These superspreading events were characterized by specific mutations assumed to originate from Mulhouse and Milan, respectively. Our analyses propose synergistic benefits of using two complementary approaches in public health surveillance, saving resources and improving surveillance efficiency.
Effect of resistance training on heart rate variability of anxious female college students
Authors: Li Ran , Yan Runsheng , Cheng Weihao , Ren Hong 
Published: December 2022

IntroductionFemale college students are a group with high incidence of anxiety, and anxiety will lead to the disorder of autonomic nervous system (ANS), which will adversely affect their study and life. Resistance training plays a positive role in improving anxiety, but there is little evidence on whether resistance training can improve ANS of anxious female college students. Heart rate variability (HRV) has gained widespread acceptance in assessing ANS modulation. Therefore, the objective of this study aimed to investigate the effects of resistance training on heart rate variability (HRV) in anxious female college student.MethodsA randomized controlled study of resistance training intervention was conducted in 27 anxious female college students that assigned randomly into an intervention group (n = 14) and a control group (n = 13). The intervention group was intervened by cluster training for 8 weeks. Self-rating anxiety scale (SAS) was used. ANS is evaluated by short-term HRV. Muscle strength was assessed by 1 RM indirect method. Independent-sample t-test was used to test post-test–pre-test scores between the intervention and control groups.ResultsAfter the intervention, SAS score of the intervention group was significantly decreased (P &lt; 0.05), SDNN of the intervention group was significantly increased (P &lt; 0.05) and LF/HF was significantly decreased (P &lt; 0.05).ConclusionThe resistance training intervention adopted in this study significantly increased the HRV of anxious female college students and improved their autonomic nervous disorder.
Analysis of content and online public responses to media articles that raise awareness of the opt-out system of consent to organ donation in England
Authors: Faherty Georgia , Williams Lorraine , Noyes Jane , Mc Laughlin Leah , Bostock Jennifer , Mays Nicholas 
Published: December 2022

BackgroundPreceded by a national media campaign, in May 2020, England switched to a soft opt-out system of organ donation which rests on the assumption that individuals meeting specific criteria have consented to organ donation unless they have expressed otherwise. We aimed to learn more about how the changes were communicated, how people responded and any discrepancies between key messages and how they were interpreted by the public.MethodsSummative content analysis of 286 stories and related reader-generated comments in leading UK online news sources (April 2019 to May 2021). Further detailed thematic analysis of 21 articles with reader-generated content, complemented by thematic content analysis coding of all 286 stories.ResultsMost media coverage on both organ donation and the law change was positive, with little variation over time or between publications. The importance of organ donation, benefits of the law change, and emotive stories (often involving children) of those who had donated an organ described as “superheroes” or those who had received organs as benefiting from a “miracle” were frequently cited. In contrast, reader-generated comments were markedly more negative, for example, focusing on loss of individual freedom and lack of trust in the organ donation system. Commentators wished to be able to choose who their organs were donated to, were dismissive and blaming towards minority ethnic groups, including undermining legitimate worries about the compatibility of organ donation with religious beliefs and end of life cultural norms, understanding and acceptance of brain-stem death and systemic racism. Misinformation including use of inflammatory language was common.ConclusionThe portrayal of donors and recipients as extraordinary is unlikely to help to normalise organ donation. Undermining legitimate concerns, in particular those from ethnic minorities, can alienate and encourage harmful misinformation in underrepresented groups. The discrepancies between the tone of the articles and the readers comments suggests a lack of trust across the public, health, policy and media outlets. Easily accessible, ongoing and tailored sources are needed to mitigate misinformation and disinformation and ensure key messages are better understood and accepted in order to realise the ambitions of soft opt-out organ donation policies.
Establishment of a teaching hospital-based dementia consultation service for rurally-based regional district general hospitals
Authors: Schott Björn H. , Voetlause Jakob Christian , Amoah Juliana Lisa , Kratzenberg Alexander , Belz Michael , Knipper Tobias , Timäus Charles , Beskow Carmen , Sweeney-Reed Catherine M. , Wiltfang Jens , Radenbach Katrin 
Published: December 2022

ObjectiveThe treatment of patients with dementia poses a considerable challenge to regional district general hospitals, particularly in rural areas. Here we report the establishment and initial evaluation of a dementia-specific consultation service provided by a teaching hospital-based Psychiatry Department to regional district general hospitals in surrounding smaller towns.MethodsThe consultation service was provided to patients with pre-existing or newly suspected dementia, who were in acute hospital care for concurrent conditions. An evaluation of 61 consultations – 49 on-site and 12 via telemedicine – was performed to assess the needs of the participating hospitals and the specific nature of the referrals to the consultation service.ResultsSuspected dementia or cognitive dysfunction was the primary reason for consultation requests (&gt;50% of cases). Other common requests concerned suspected delirium, behavioral symptoms, and therapeutic recommendations. During the consultations, a diagnosis of dementia was reached in 52.5% of cases, with other common diagnoses including delirium and depression. Recommendations related to pharmacotherapy were given in 54.1% of consultations. Other recommendations included referral for outpatient neurological or psychiatric follow-up, further diagnostic assessment, or assessment in a memory clinic. Geriatric psychiatric inpatient treatment was recommended in only seven cases (11.5 %).ConclusionOur initial evaluation demonstrates the feasibility of providing a dementia-specific consultation service in rural areas. The service has the potential to reduce acute transfers to inpatient geriatric psychiatry and enables older patients with dementia or delirium to be treated locally by helping and empowering rurally-based regional hospitals to manage these problems and associated complications.