bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke: The Glycoprotein VI in Stroke (GYPSIE) study results
Authors: Induruwa Isuru , McKinney Harriet , Kempster Carly , Thomas Patrick , Batista Joana , Malcor Jean-Daniel , Bonna Arkadiusz , McGee Joanne , Bumanlag-Amis Elaine , Rehnstrom Karola , Ashford Sophie , Soejima Kenji , Ouwehand Willem , Farndale Richard , Downes Kate , Warburton Elizabeth , Moroi Masaaki , Jung Stephanie 
Published: January 2022

Objectives
Platelet activation underpins thrombus formation in ischemic stroke. The active, dimeric form of platelet receptor glycoprotein (GP) VI plays key roles by binding platelet ligands collagen and fibrin, leading to platelet activation. We investigated whether patients presenting with stroke expressed more GPVI on their platelet surface and had more active circulating platelets as measured by platelet P-selectin exposure.

Methods
129 ischemic or hemorrhagic stroke patients were recruited within 8h of symptom onset. Whole blood was analyzed for platelet-surface expression of total GPVI, GPVI-dimer, and P-selectin by flow cytometry at admission and day-90 post-stroke. Results were compared against a healthy control population (n = 301).

Results
The platelets of stroke patients expressed significantly higher total GPVI and GPVI-dimer (P<0.0001) as well as demonstrating higher resting P-selectin exposure (P<0.0001), a measure of platelet activity, compared to the control group, suggesting increased circulating platelet activation. GPVI-dimer expression was strongly correlated circulating platelet activation [r2 = 0.88, P<0.0001] in stroke patients. Furthermore, higher platelet surface GPVI expression was associated with increased stroke severity at admission. At day-90 post-stroke, GPVI-dimer expression and was further raised compared to the level at admission (P<0.0001) despite anti-thrombotic therapy. All ischemic stroke subtypes and hemorrhagic strokes expressed significantly higher GPVI-dimer compared to controls (P<0.0001).

Conclusions
Stroke patients express more GPVI-dimer on their platelet surface at presentation, lasting at least until day-90 post-stroke. Small molecule GPVI-dimer inhibitors are currently in development and the results of this study validate that GPVI-dimer as an anti-thrombotic target in ischemic stroke.
Quality of life of patients with rheumatic diseases during the COVID-19 pandemic: The biopsychosocial path
Authors: Guaracha-Basáñez Guillermo A. , Contreras-Yáñez Irazú , Hernández-Molina Gabriela , Estrada-González Viviana A. , Pacheco-Santiago Lexli D. , Valverde-Hernández Salvador S. , Galindo-Donaire José Roberto , Peláez-Ballestas Ingris , Pascual-Ramos Virginia 
Published: January 2022

Background
Previous models that assess quality-of-Life (QoL) in patients with rheumatic diseases have a strong biomedical focus. We evaluated the impact of COVID-19 related-health care interruption (HCI) on the physical, psychological, social relationships and environment QoL-dimensions, and explored factors associated with QoL when patients were reincorporated to the outpatient clinic, and after six-month follow-up.

Patients and methods
Study phase-1 consisted of a COVID-19 survey administered from June 24th-October 31st 2020, to outpatients with rheumatic diseases who had face-to-face consultation at outpatient clinic reopening. Study phase-2 consisted of 3 consecutive assessments of patient´s QoL (WHOQOL-BREF), disease activity/severity (RAPID-3), and psychological comorbidity/trauma (DASS-21 and IES-R) to patients from phase-1 randomly selected. Sociodemographic, disease and treatment-related information, and comorbidities were obtained. Multiple linear regression analysis identified factors associated with the score assigned to each WHOQOL-BREF dimension.

Results
Patients included (670 for phase-1 and 276 for phase-2), had primarily SLE and RA (44.2% and 34.1%, respectively), and all the dimensions of their WHOQOL-BREF were affected. There were 145 patients (52.5%) who referred HCI, and they had significantly lower dimensions scores (but the environment dimension score). Psycho-emotional factors (primarily feeling confused, depression and anxiety), sociodemographic factors (age, COVID-19 negative economic impact, years of scholarship, HCI and having a job), and biomedical factors (RAPID-3 score and corticosteroid use) were associated with baseline QoL dimensions scores. Psycho-emotional factors showed the strongest magnitude on dimensions scores. Most consistent predictor of six-month follow-up QoL dimensions scores was each corresponding baseline dimension score, while social determinants (years of scholarship and having a job), emotional factors (feeling bored), and biomedical aspects (RAPID 3) had an additional impact.

Conclusions
HCI impacted the majority of patient´s QoL dimensions. Psycho-emotional, sociodemographic and biomedical factors were consistently associated with QoL dimensions scores, and these consistently predicted the QoL trajectory.
El traductor es un trabajador como otro cualquiera…, y es muy importante que no esté solo
Authors: Gallego Urrutia María Teresa 
Published: January 2022

María Teresa Gallego Urrutia nació en Madrid en el año 1943. Realizó sus estudios en el Liceo francés de Madrid y fue allí donde se licenció en Filología Moderna Francesa años más tarde por la Universidad Complutense. Su andadura por la traducción literaria comenzó en 1961 y, desde entonces y hasta el momento, ha traducido alrededor de 200 obras de los autores franceses y francófonos más destacados. Encontramos entre ellos a Albert Camus, Honoré de Balzac, Víctor Hugo o Marcel Proust. En el año 1974, obtuvo la cátedra de francés del Instituto Gregorio Marañón de Madrid. Por su trayectoria como traductora ha recibido numerosos reconocimientos, entre los que podemos nombrar el Premio Nacional de Traducción de Lenguas Románicas por El diario de un ladrón de Jean Genet en 1977 y el premio Stendhal por Impresiones de África de Raymond Roussel, ambos compartidos con Isabel Reverte Cejudo. Además ha recibido la condecoración Ordre des Arts et des Lettres por el Gobierno francés en el año 2003 y, cinco años más tarde, recibió el Premio Nacional a la obra de un traductor. En el año 2011 recibió el premio Mots Passants que concede el Departamento de francés de la Universidad Autónoma de Barcelona por su traducción de El horizonte de Patrick Modiano. Finalmente, en 2003 recibió el premio Esther Benítez por su traducción de La señora Bovary de Gustave Flaubert.
Aunque dio sus primeros pasos en el mundo de la traducción jurídica, María Teresa Gallego Urrutia es una traductora literaria de referencia que nunca ha descuidado su faceta docente. Desde 2008 hasta 2013, impartió clases sobre derecho de propiedad intelectual del traductor en el Instituto de traductores de la Universidad Complutense de Madrid. Colabora activamente con publicaciones como el Trujamán, del Instituto Cervantes, la revista Turia y Letra Internacional, entre otros.
Se requieren cada vez más intérpretes para trabajar en zonas y situaciones que se derivan de un conflicto
Authors: Ruiz Rosendo Lucía 
Published: January 2022

Esta entrevista se desarrolló en el marco del VIII Seminario de Traducción Jurídica e Institucional para Organizaciones Internacionales, celebrado en la Universidad de Salamanca entre el 17 y el 21 de febrero de 2020. La entrevistada había sido invitada para dar una conferencia plenaria titulada «Los intérpretes en zonas y situaciones de conflicto: Contextos institucionales y retos».
Los conflictos armados y, por consiguiente, la mediación lingüística en las zonas y situaciones de conflicto, son omnipresentes en la historia de la humanidad. Los conflictos surgen como respuesta a una amenaza, ya sea como resultado de diferencias entre pueblos y naciones o en medio de una comunidad. Cuando una de las partes no habla la lengua de la otra, es necesario recurrir a algún tipo de mediación lingüística. A pesar de la invisibilidad frecuente de los intérpretes en estas situaciones, su necesidad e importancia es incontestable. A nivel internacional, son muchas las instituciones que recurren a los intérpretes para desempeñar su labor en las zonas de conflicto, tales como la ONU, el CICR (Comité Internacional de la Cruz Roja), la CPI (Corte Penal Internacional) o la OTAN, entre otras. En la conferencia, y también en la presente entrevista, se abordaron distintos aspectos relacionados con la profesión del intérprete y la formación en interpretación, en general, y con la interpretación en zonas y situaciones en conflicto, en particular. Se mencionaron los distintos contextos institucionales y perfiles de intérpretes que trabajan en zonas de conflicto. Asimismo, se expusieron los retos a los que se enfrentan, por una parte, los intérpretes en su cometido, y, por otra parte, las instituciones a la hora de contratar a estos intérpretes y de trabajar con ellos.
Fibrosis-4 Index Can Independently Predict Major Adverse Cardiovascular Events in Nonalcoholic Fatty Liver Disease
Authors: Vieira Barbosa Joana , Milligan Scott , Frick Andrew , Broestl Jeremy , Younossi Zobair , Afdhal Nezam , Lai Michelle 
Published: January 2022

INTRODUCTION:
Nonalcoholic fatty liver disease (NAFLD) is closely associated with an increased risk of cardiovascular disease. We aimed to determine whether the fibrosis-4 index (FIB-4) can identify patients with NAFLD at highest risk of cardiovascular events.

METHODS:
We analyzed data from 81,108 patients with (i) a diagnosis of NAFLD, (ii) nonalcoholic steatohepatitis (NASH), or (iii) at risk (RISK) of NASH. The outcome of interest was major adverse cardiovascular events (MACE) defined by myocardial infarction, hospitalization for unstable angina or heart failure, and coronary revascularization.

RESULTS:
The mean age was 62 years, and 49.6% were men. Among 67,273 patients without previous cardiovascular disease, 9,112 (13.5%) experienced MACE over median follow-up of 3 years. In univariate analysis, a FIB-4 ≥2.67 was a significant predictor of MACE overall (hazard ratio [HR] 1.82, 95% confidence interval [CI] 1.63–2.04, P < 0.001) and across all baseline groups. After adjusting for established cardiovascular risk factors, FIB-4 ≥2.67 remained the strongest predictor of MACE overall (adjusted HR [aHR] 1.80, 95% CI 1.61–2.02, P < 0.001) and was consistently associated with myocardial infarction (aHR 1.46, 95% CI 1.25–1.70, P < 0.001), hospitalization for unstable angina (aHR 1.24, 95% CI 1.03–1.49, P = 0.025), hospitalization for heart failure (aHR 2.09, 95% CI 1.86–2.35, P < 0.001), coronary artery bypass graft (aHR 1.65, 95% CI 1.26–2.17, P < 0.001), and percutaneous coronary intervention (aHR 1.72, 95% CI 1.21–2.45, P = 0.003).

DISCUSSION:
In a large, real-world cohort of patients with NAFLD, NASH, or at RISK of NASH, the FIB-4 score was the strongest independent predictor of MACE, beyond established cardiovascular risk factors and baseline liver diagnosis.
A Single Fasting Exhaled Methane Level Correlates With Fecal Methanogen Load, Clinical Symptoms and Accurately Detects Intestinal Methanogen Overgrowth
Authors: Takakura Will , Pimentel Mark , Rao Satish , Villanueva-Millan Maria Jesus , Chang Christine , Morales Walter , Sanchez Maritza , Torosyan John , Rashid Mohamad , Hosseini Ava , Wang Jiajing , Leite Gabriela , Kowalewski Edward , Mathur Ruchi , Rezaie Ali 
Published: January 2022

INTRODUCTION:
A 2-hour breath test is the gold standard for diagnosing intestinal methanogen overgrowth (IMO). This method can be cumbersome especially if used repetitively to monitor treatment response. Therefore, we aimed to assess the reliability of a fasting single methane measurement (SMM) in diagnosing IMO and its utility as a biomarker to monitor treatment response in subjects with IMO.

METHODS:
First, we calculated the test characteristics of SMM compared with lactulose and glucose breath test in 2 large-scale retrospective cohorts. Second, the symptomology associated with SMM using various cutoffs was analyzed. Third, in a double-blind randomized control trial, the temporal stability of SMM levels in subjects taking placebo was analyzed. Fourth, stool Methanobrevibacter smithii loads were quantified using quantitative polymerase chain reaction and compared with SMM levels. Last, the change in SMM over time during antibiotic therapy was analyzed.

RESULTS:
Using the cutoff of SMM ≥10 ppm, SMM had a sensitivity of 86.4% and specificity of 100% for diagnosing IMO on the glucose and lactulose breath tests and was associated with constipation (5.65 ± 3.47 vs 4.32 ± 3.62, P = 0.008). SMM remained stable for 14 weeks without treatment (P = 0.45), and antibiotics lead to a decrease in SMM after 2 days (P < 0.0001). SMM was positively associate with stool M. smithii load (R = 0.65, P < 0.0001).

DISCUSSION:
Fasting SMM ≥10 ppm seems to accurately diagnose IMO, is associated with constipation, and correlates with stool M. smithii. SMM seems to be stable without treatment and decreases after antibiotics. SMM may be a useful test to diagnose IMO and monitor treatment response.
Metastatic Head and Neck Squamous Cell Carcinoma Masquerading as Crohn's Disease
Authors: Bhaskar Sonya , Mony Shruti , Taunk Pushpak 
Published: January 2022

ABSTRACT
Metastasis from head and neck tumors to the small intestine is an extremely rare occurrence with a dismal prognosis. We present a 67-year-old man with metastatic head and neck squamous cell carcinoma that initially presented as recurrent small bowel obstruction and was misdiagnosed as Crohn's disease. On colonoscopy, terminal ileum biopsies of lymphoid-appearing subcentimeter nodules were positive for metastatic squamous cell cancer. Our case highlights the importance of having a high index of suspicion for metastasis in patients with a recent history of head and neck cancers.
Rapidly Extensive Recurrence of Esophageal Neuroendocrine Carcinoma After Complete Pathologic Response to Definitive Chemoradiation
Authors: Wang Maxwell M. , Singh Simi K. 
Published: January 2022

ABSTRACT
Primary esophageal neuroendocrine carcinoma is a rare, aggressive malignancy lacking evidence-based treatment guidelines. The timing and nature of relapse after successful treatment of locoregional disease are not well characterized. We report a patient lacking risk factors for esophageal cancer who rapidly developed extensive disease recurrence 4 months after achieving complete pathologic response to nonsurgical treatment. Although optimal survival for early stage nonmetastatic disease is achieved by esophagectomy with adjuvant therapy, definitive chemotherapy is also appropriate for late stage nonmetastatic patients. There are presently no protocols for maintenance therapy. We highlight complex treatment considerations for this rare malignancy.
How many α-amylase GH families are there in the CAZy database?
Authors: Janeček Štefan , Svensson Birte 
Published: January 2022

Abstract
The CAZy database is a web-server for sequence-based classification of carbohydrate-active enzymes that has become the worldwide and indispensable tool for scientists engaged in this research field. It was originally created in 1991 as a classification of glycoside hydrolases (GH) and currently, this section of CAZy represents its largest part counting 172 GH families. The present Opinion paper is devoted to the specificity of α-amylase (EC 3.2.1.1) and its occurrence in the CAZy database. Among the 172 defined GH families, four, i.e. GH13, GH57, GH119 and GH126, may be considered as the α-amylase GH families. This view reflects a historical background and traditions widely accepted during the previous decades with respect to the chronology of creating the individual GH families. It obeys the phenomenon that some amylolytic enzymes, which were used to create the individual GH families and were originally known as α-amylases, according to current knowledge from later, more detailed characterization, need not necessarily represent genuine α-amylases. Our Opinion paper was therefore written in an effort to invite the scientific community to think about that with a mind open to changes and to consider the seemingly unambiguous question in the title as one that may not have a simple answer.
The Body, Experience, and the History of Dream-Science in Artemidorus’Oneirocritica
Authors: Scott Calloway B. 
Published: January 2022

AbstractThe five books of Artemidorus of Ephesus’ Oneirocritica (c. second century CE) constitute the largest collection of divinatory dream-interpretations to survive from Graeco-Roman antiquity. This article examines Artemidorus’ contribution to longstanding medico-philosophical debates over the ontological and epistemic character of such dreams. As with wider Mediterranean traditions concerning premonitory dreams, Greeks and Romans popularly understood them as phenomena with origins exterior to the dreamer (e.g. a visitation of a god). Presocratic and Hippocratic thinkers, however, initiated an effort to bring at least some dream events within the body as interior processes of a physical soul, a bodily turn which ultimately engendered a split in thinking about the possibility and scope of prophetic and diagnostic dreams (e.g. Hippocrates Regimen 4, Aristotle On Prophecy in Dreams, Rufus of Ephesus, and Galen). Here, I examine the way that Artemidorus meant the Oneirocritica to address seriously questions about the origins of dreams and the powers of empirical science in two, related ways. We will see that his defense of oneirocriticism as a techne unfolds along two main axes. First, Artemidorus constructs a necessary veneer of scientific credibility by mobilizing the tropes and organizational strategies characteristic of contemporary technical literature. Secondly, he anchors that authority upon a materialist account of prophetic dreams as “semiotic movements of the soul.” As Price, S. 1986. “The Future of Dreams: From Freud to Artemidorus.”Past & Present113: 3–36 and Harris-McCoy, D. 2012.Artemidorus’ Oneirocritica: Text, Translation, and Commentary. Oxford: Oxford University Press observed, this explicit commitment to an empirical method of dream-interpretation resembles that of the Hellenistic medical ‘sect’ known as ‘Empiricists,’ who eschewed interest in theoretical etiology in favor of observation, comparison, and compilation of symptoms and outcomes. Pushing beyond similarity, I argue that Artemidorus not only deployed this method to defend empirically grounded accounts of dream-divination (cf. Cicero De div. 1), but endeavored to show that such a scientific method can be used to stabilize and corral productively the potentially infinite number of interpretations any dream-sign might bear without recourse to an underlying, causal theory.
Investigation of molecular regulation mechanism under the pathophysiology of subarachnoid hemorrhage
Authors: Weng Yifei 
Published: January 2022

Abstract
This study aimed to investigate the molecular mechanism under the pathophysiology of subarachnoid hemorrhage (SAH) and identify the potential biomarkers for predicting the risk of SAH. Differentially expressed mRNAs (DEGs), microRNAs, and lncRNAs were screened. Protein–protein interaction (PPI), drug–gene, and competing endogenous RNA (ceRNA) networks were constructed to determine candidate RNAs. The optimized RNAs signature was established using least absolute shrinkage and selection operator and recursive feature elimination algorithms. A total of 124 SAH-related DEGs were identified, and were enriched in inflammatory response, TNF signaling pathway, and others. PPI network revealed 118 hub genes such as TNF, MMP9, and TLR4. Drug–gene network revealed that chrysin targeted more genes, such as TNF and MMP9. JMJD1C-AS-hsa-miR-204-HDAC4/SIRT1 and LINC01144-hsa-miR-128-ADRB2/TGFBR3 regulatory axes were found from ceRNA network. From these networks, 125 candidate RNAs were obtained. Of which, an optimal 38 RNAs signatures (2 lncRNAs, 1 miRNA, and 35 genes) were identified to construct a Support Vector Machine classifier. The predictive value of 38 biomarkers had an AUC of 0.990. Similar predictive performance was found in external validation dataset (AUC of 0.845). Our findings provided the potential for 38 RNAs to serve as biomarkers for predicting the risk of SAH. However, their application values should be further validated in clinical.
Plant growth-promoting properties of bacterial endophytes isolated from roots of Thymus vulgaris L. and investigate their role as biofertilizers to enhance the essential oil contents
Authors: Abdel-Hamid Mahmoud Soliman , Fouda Amr , El-Ela Hesham Kamal Abo , El-Ghamry Abbas A. , Hassan Saad El-Din 
Published: January 2022

Abstract
The main objective of the current study was to improve the essential oil contents of Thymus vulgaris L. using bio-inoculation with bacterial endophytes. Therefore, out of fourteen endophytic bacterial isolates obtained from roots of T. vulgaris, five isolates were selected based on the highest nitrogen-fixation and phosphate solubilization activity and identified as: Bacillus haynesii T9r, Citrobacter farmeri T10r, Bacillus licheniformis T11r, Bacillus velezensis T12r, and Bacillus velezensis T13r. These five strains have been recorded as ammonia, hydrogen cyanide (HCN), siderophores, and indole-3-acetic acid (IAA) producers. These strains have the efficacy to fix-nitrogen by reduction of acetylene with values of 82.133±1.4–346.6±1.4 n-mole-C2H4/ml/24 h. The IAA, gibberellic acid, abscisic acid, benzyl, kinten, and ziaten production were confirmed using HPLC. Two strains of T11r and T13r showed the highest plant growth-promoting properties and were selected for bio-inoculation of T. vulgaris individually or in a consortium with different mineral fertilization doses (0, 50, 75, and 100%) under field conditions. The highest growth performance was attained with the endophytic consortium (T11r+T13r) in the presence of 100% mineral fertilization. The GC-MS analysis of thyme oil contents showed the presence of 23 various compounds with varying percentages and the thymol fraction represented the highest percentages (39.1%) in the presence of the bacterial consortium.
Implication of plant growth-promoting rhizobacteria ofBacillusspp. as biocontrol agents against wilt disease caused byFusarium oxysporumSchlecht. inVicia fabaL.
Authors: El-Sersawy Mostafa Mohamed , Hassan Saad El-Din , El-Ghamry Abbas A. , El-Gwad Amr Mahmoud Abd , Fouda Amr 
Published: January 2022

AbstractOut of sevenFusariumspp. isolated from infected faba bean roots, twoFusarium oxysporumwere selected and showed faba bean-wilt disease severity with percentages of 68% and 47% under greenhouse conditions. TheF. oxysporumshowed the highest wilt disease was selected to complete the current study. Three rhizobacterial strains were isolated and identified asBacillus velezensisVb1,B. paramycoidesVb3, andB. paramycoidesVb6. These strains showed the highestin-vitroantagonistic activity by the dual-culture method against selectedF. oxysporumwith inhibition percentages of 59±0.2, 46±0.3, and 52±0.3% for Vb1, Vb3, and Vb6, respectively. These rhizobacterial strains exhibit varied activity for nitrogen-fixing and phosphate-solubilizing. Moreover, these strains showed positive results for ammonia, HCN, and siderophores production. The phytohormones production (indole-3-acetic acid, ABA, benzyl, kinten, ziaten, and GA3) and secretion of various lytic enzymes were recorded by these strains with varying degrees. Under greenhouse conditions, the rhizobacterial strains Vb1, Vb3, Vb6, and their consortium can protect faba bean from wilt caused byF. oxysporumwith percentages of 70, 60, 65, and 82%, respectively. Under field conditions, the inoculation with the rhizobacterial consortium (Vb1+Vb3+Vb6) significantly increases the growth performance of theF. oxysporum-infected faba bean plant and recorded the highest wilt protection (83.3%).