bluuebunny/crossref_metadata_2025_split huggingface dataset:
SNORA5A regulates tumor-associated macrophage M1/M2 phenotypes via TRAF3IP3 in breast cancer
Authors: Zhang Yiqi , Zheng Ang , Shi Yue , Lu Heng 
Published: November 2022

Abstract
SnoRNAs have robust potential functions and therapeutic value in breast cancer. Herein, we investigated the role SNORA5A in breast cancer. This study reviewed samples from TCGA. The transcription matrix and clinical information were analyzed using R software and validated in clinical tissue sample. SNORA5A was significantly down-regulated in breast cancer and high expression of SNORA5A correlated with a favorable prognosis. High expression of SNORA5A induced high concentration of tumor-associated macrophages M1 and low concentration of tumor-associated macrophages M2. Moreover, SNORA5A were clustered in terms related to cancer and immune functions. Possible downstream molecules of SNORA5A were identified, among which TRAF3IP3 was positively correlated with M1 and negatively correlated with M2. The function of TRAF3IP3 in tumor inhibition and its relation with macrophages in clinical tissue samples were in accordance with bioinformatics analysis results. Hence, SNORA5A could regulate macrophage phenotypes through TRAF3IP3 and serves as a potential prognostic marker for breast cancer patients.
A Mechanical Analysis of Zhang’s knot, a New Slip Knot with Locking Mechanism
Authors: Han Qing-xin , Ma Jia , Zhang Lei , Tong Yi , Li Yan 
Published: November 2022

Abstract
Background: An effective knot, which is used under the arthroscopy, must possess the optimal balance of knot security and loop security. The aim of this research was to assess the biomechanical performance of the Zhang’s knot, a new slip knot, comparing with Tennessee knot, Roeder knot, and SMC knot.
Methods: The Zhang’s knot and other 3 arthroscopic sliding knots (Tennessee knot, Roeder knot, and SMC knot) were tied with 3 reversing half-hitches on alternating posts (RHAPs) following. A total of 60 specimen of 5 different types of knots were assessed, with the static surgeon’s knot as comparison. The knots were tied around a 30 mm circumference plastic post for a unified 30 mm loop circumference before locking the complex knots by tensioning the wrapping limb of the suture. The loop security (the capacity of knot maintaining a tight suture loop without slippage) was assessed based on the circumference of knots under 5 N preload; the knot security was assessed based on the maximum force to failure at 3 mm of crosshead displacement or suture breakage during single-pull load testing.
Results: Regarding the loop circumferences, under 5 N preload, the Zhang’s knot was not significantly different from Tennessee knot (P = 0.396), but smaller than SMC knot (P = 0.029), Roeder knot (P = 0.007) and surgeon’s knot (P = 0.007). In term of load-to-failure, the Zhang’s knot was not significantly different from Tennessee knot (P = 0.077) and SMC knot (P = 0.903), but stronger than Roeder knot (P = 0.030) and surgeon’s knot (P < 0.001).
Conclusions: The Zhang’s knot is easily reproducible and shows a great balance of loop security and knot security just as Tennessee knot with 3 RHAPs.
Healthy Lifestyle and all-cause and cause-specific dementia in Individuals with or without Type 2 diabetes: the roles of diabetes duration and insulin use
Authors: Zhou Chunmiao , Dong Caiyun , Wang Qi , Fu Chunying , Xie Ziwei , Hao Wenting , Sun Huizi , Zhu Dongshan 
Published: November 2022

Abstract
Background
Diabetes and dementia share common lifestyle risk factors, while few studies have examined the effect of seven healthy lifestyle factors as recommended by the diabetes management guidelines on all-cause and cause-specific dementia in individuals with type 2 diabetes (T2DM). Also, the roles of diabetes duration and insulin therapy in their association remain unclear.
Methods
This study analyzed data of 459 840 participants from the UK Biobank. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CI) for the association of an overall healthy lifestyle score (derived from smoking, social connection, alcohol consumption, physical activity, sedentary, sleep duration and diet) with all-cause and cause-specific dementia of Alzheimer's disease (AD), Vascular dementia (VD) and Non-Alzheimer non-vascular dementia (NAVD), using people without T2DM as the reference group. We also analyzed the role of diabetes duration and insulin use on the association between lifestyle score and dementia.
Results
During a mean follow-up of 12.1 years, 5 268 incident dementia events were recorded. Using diabetes-free participants who had a lifestyle score of 5–7 as reference group, in diabetes-free participants, we observed a clear trend that higher healthy lifestyle score was related to lower risk of all-cause and cause-specific dementia. However, in people with T2DM, we did not observe such a trend with all-cause dementia. People with lifestyle score of 2–3, 4 and 5–7 all had around two-time risk of all-cause dementia (HR: 2.20–2.36), while those with a score of 0–1 had over three-time risk (HR: 3.14, 95% CI 2.34–4.21). After separating the analyses with dementia subtypes, a dose-response trend was only observed with VD (each two-point increase: 0.75, 0.61–0.93), and no significant association with AD (0.95, 0.77–1.16). The reduced risk of all-cause dementia, AD, VD, and NACD with higher lifestyle score was only observed in patients with diabetes duration less than 10 years, or in patients with no insulin use.
Conclusions
In people with T2DM, higher healthy lifestyle score was associated with lower risk of all-cause dementia, while the relationship with cause-specific dementia was inconsistent. A dose-response trend was only observed with VD, not with AD. The beneficial effect of healthy lifestyle was only observed in people with diabetes duration less than 10 years, or in those with no insulin use.
A versatile hybrid image fusion model to fuse multispectral image data
Authors: Ignatious Henry Alexander , El-Sayed Hesham , Khan Manzoor Ahmed , Kulkarni Parag 
Published: November 2022

Abstract
Higher-level autonomous driving necessitates the best possible execution of important moves under all conditions. Most of the accidents in recent years caused by the AVs launched by leading automobile manufacturers are due to inadequate decision-making caused by their poor perceivance of environmental information. In todays, technology-bound scenarios, versatile sensors are used by AVs to collect environmental information. Due to various technical and natural calamities, the environmental information acquired by the sensors may not be complete and clear, due to which the AVs may misinterpret the information in a different context leading to inadequate decision making causing fatal accidents. To overcome this drawback effective preprocessing of raw sensory data is a mandatory task. Pre-processing the sensory data involves two vital tasks namely data cleaning and data fusion. Since the raw sensory data is complex and exhibits multimodal characteristics, more emphasis is given to data preprocessing. Since more innovative models have been proposed for data cleaning, this study focuses on data fusion. In particular, we propose a generic data fusion engine, which classifies different formats of sensory data and fuses them accordingly to improve accuracy. This study proposes a generic framework to fuse the text, image, and audio data. In the first stage of this research, an innovative hybrid model is proposed to fuse multispectral image and video data. Simple and efficient models to extract the salient image features are also proposed. The proposed models are evaluated using various standard metrics with existing popular models. The proposed image fusion model performed better than the other models.
A Study on the Possible Mediating Role of Covid-19 Pandemic in Psychological Distress and Disordered Eating Behaviours Among Young Adults
Authors: Awasthi Snigdha , Ephraim Rufus 
Published: November 2022

Abstract
Background
The COVID-19 pandemic-associated social restrictions brought various challenges among the youth, including mental health issues and disordered eating patterns. It, therefore, becomes imperative for clinicians to know the extent and causative factors of the problem.
Objectives
To explore the prevalence and possible mediation role of the COVID-19 pandemic in causing mental distress and disordered eating behaviors among Indian adults between 18–35 years old.
Methods
This was a month-long, community-based, cross-sectional study conducted via an online questionnaire. The Coronavirus Impact Scale (CIS), Depression, Anxiety, Stress Scale (DASS-21), SCOFF questionnaire for eating disorders, and Three-Factor Eating Questionnaire-Revised 18-item version (TFEQ-18) were used. In addition, the mediation effects of the psychosocial impact of the pandemic, psychological distress, and disordered eating behaviors, were tested using PROCESS v4.0 by Andrew Hayes.
Results
49% of the subjects (n = 101) reported stress and discord in their families due to the pandemic. 10% of the respondents reported features suggestive of moderate depression and anxiety, while almost 10% of the participants suffered from a likely eating disorder, requiring further clinical evaluation. A positive association was observed between psychosocial stress due to COVID-19 and depression (r = 0.366, p < 0.001), anxiety (r = 0.402, p < 0.001) and stress (r = 0.416, p < 0.001). Also, on mediation analysis, the pandemic-induced psychological distress was found to significantly affect disordered eating patterns (b = 0.104, CI = 0.09, 2.17).
Conclusions
The COVID-19 pandemic has caused or aggravated significant psychological distress and, in turn, has indirectly mediated disordered eating patterns among the younger population, who are already at higher risk for developing mental disorders.
Improved Macromodeling Helps Sizing of Multi-stage Op Amps – A Case Study
Authors: Xie Qixu , Shi Guoyong 
Published: November 2022

Abstract
Behavioral modeling of analog integrated cir- cuits has many applications. When used for sizing, ac- curacy of compact models can be used for directly eval- uating part of circuit performance targets, helping to quickly forming initial sizing for further iterations. In this paper we elaborate on modeling improvement of the current buffer (CB) compensation recently received attention in multi-stage operational amplifier (op amp) designs. Limitation in conventional models is pointed out and improvement is proposed. We demonstrate via cases that the improved macromodels can leverage the eﬀiciency of sizing by incorporating the gm/ID method.
Knowledge of Stroke Risk Factors and Warning Signs Among High Risk Individuals in Nnewi North and South Local Government Areas, Anambra State, Nigeria
Authors: Akosile Christopher Olusegun , Okonkwo Uchenna Prosper , Aninyei Desmond , Raji Najim Olayiwola , Abdullahi Auwal , Okoye Emmanuel Chiebuka , Odetunde Morufat Oluyemisi , Akobundu Uzoamaka Nwakego , Okafor Christiana Nkiru 
Published: November 2022

Abstract

Background: Increasing the level of knowledge of stroke risk factors and warning signs among individuals at high risk for stroke may empower them for positive health actions.Aim: This study assessed the knowledge of stroke risk factors and warning signs among individuals at increased risk and the association between these knowledge levels and some of the participants’ demographics.Method:This study was a cross-sectional survey of one hundred and forty-six individuals (mean age= 53.16±17.66 years) at high risk for stroke from some selected communities in Nnewi North and South Local Government Areas, Anambra State. A self-developed questionnaire was used to measure the participants’ knowledge level.Data Analysis:Data obtained were analyzed using descriptive statistics of frequency counts, percentages, mean and standard deviation while inferential statistics of Chi-square and Spearman rank-order correlation were used for testing the hypotheses at 0.05 alpha-level.Result:Participants' were mostly males 98 (65.07%), married, and gainfully employed (67.1%) and had at least a secondary level education (76.7%). About half of the participants had poor knowledge of stroke risk factors (52.05%) and warning signs (49.32%) despite their high literacy level. Being a male participant with a tertiary level of education and working in the public or private sector was associated with a better knowledge level (p≤0.05). No significant association existed between the age and marital status of the individuals. Knowledge of stroke risk factors and warning signs was poor for many in the sampled population particularly those with little or no education and those who are either unemployed or self-employed. Efforts should be made to increase the level of awareness among these groups of high-risk individuals through stroke awareness campaigns, which may empower them for positive health actions toward stroke prevention.
Reflective practice and self-reliance development among nursing students
Authors: ATMANI Zineb EL , BELLFKIH EL MEHDI , MADRANE MOURAD 
Published: November 2022

Abstract
The nursing student walks through a complex study system in a field full of challenges. He is called upon to embark on a three-year training program that should foster a better link between theory and practice and be part of a professionalization approach, thus ensuring the development of his autonomy. In such a context, taking a step back and questioning the practice on the part of each student remains an area rarely explored. Following the implementation of the competency-based approach, the development of reflective practice (RP) in students and the need to stimulate critical thinking skills in them are a priority. From this perspective, this study aims to study the development of RP among 200 students from 21 ISPITS (Higher Institute of Nursing Professions and Health Technologies) from different corners of the Kingdom of Morocco. It is done using a questionnaire, the internal validity of which has been approved, sent through the Google Forms platform. As such, this quantitative study will focus on two aspects on the first is descriptive exploratory to study the level of development of RP in ISPITS. The second aims to study the relationship between RP and the development of autonomy among nursing students and to verify the existence of a possible impact on their academic success. The results show a positive impact on the importance given to RP in ISPITS training. Also, the statistical tests demonstrated a positive impact of the RP on the development of autonomy and on the students' success.
Substantiation of the efficiency of the method for processing viburnum by the method of osmotic dehydration
Authors: Samilyk Marina , Korniienko Daria , Demidova Evgenia , Tymoshenko Anna , Bolgova Natalia , Yeskova Oksana 
Published: November 2022

In the process of any food production, it is important not only to obtain a high quality product, but also to minimize industrial waste, reduce energy costs for the process. Recently, buyers are also paying special attention to the biological value, the popularity of organic and natural products is growing. The search for new types of non-traditional raw materials and the choice of a rational way of processing it is an important task for scientists and manufacturers. The subject of the study was the viburnum fruits (Viburnum opulus). The object is the process of osmotic dehydration. The purpose of the study is to substantiate the effectiveness of the method of processing Viburnum opulus fruits by the method of osmotic dehydration. The process of processing viburnum fruits provides for mandatory pre-freezing, defrosting, osmotic dehydration and drying. A method was developed for waste-free processing of viburnum fruits using the process of osmotic dehydration. Products of viburnum processing (osmotic solution and powders) were studied. Analysis of the mineral composition of powders of their derivatives from the processing of viburnum showed the highest content of potassium (5.74 %). In addition, vitamin C was found in the products of viburnum processing: in powders – 8.28 mg/100 g, in an osmotic solution − 1.12 mg/100 ml. Given that wild berries were used for the study, a study of powders for the presence of microorganisms and heavy metals was carried out. Mesophilic aerobic, facultative anaerobic microorganisms, yeasts and molds were not detected. The content of heavy metals is less than 10 ppm Pb. Thus, viburnum fruits are safe raw materials. When using osmotic dehydration, their biological value and organoleptic properties are preserved.
The spread of Parlatoria cinerea Hadden 1909, and the plants which it parazitises in the south of Albania
Authors: Hasani Lavdi 
Published: November 2022

In the following material, the role of one of the parasites of citrus fruits and ornamental plants is treated, that of Parlatoria cinerea Hadden 1909. Among the representatives of the U/Order Coccinea, Order Hemiptera, Class Insecta, P. cinerea Hadd. 1909; is presented as one of the most widespread pests among all representatives of the Parlatoria genus analyzed in our study. To determine this species, it is necessary to familiarize ourselves with many of its determining characteristics. It should be emphasized that, in this material, the distribution of this species in the entire territory kept under control is also dealt with. This group of parasites precisely in the Region of South-Western Albania has studied.
The paper, in addition to the spread of the species in question, also identifies the entire variety of vegetation that it frequents, the plant organs where the insect prefers to parasitize, and also the frequency of plant liking by it.
In this paper, in addition to the species P.cinerea Hadden 1909, data on other representatives of the genus ParlatoriaTargini - Tozzetti, 1868 are also treated, such as: P. eleae Colv., P. thea Ckll. and P. pergandii Comst. By presenting in a comparative manner the data collected for all these species found in the region in question, the role and importance of the study of this species is highlighted. The material also deals with data on the damage caused by it and the negative impacts on the contaminated vegetation. Thus, on the basis of a chronological work in the field of over 5 years, we have also reached a number of valuable conclusions for citrus growers and equally for park specialists who cultivate and breed ornamental plants in parks of relaxation and in the courtyards of our homes.
Research on accuracy of electrical energy measurement in microgrid for mine dewatering
Authors: Vasylets Kateryna , Vasylets Sviatoslav , Kylymchuk Anton 
Published: November 2022

The object of the study is the current transformers of the electricity metering unit as part of the microgrid for mine dewatering, which includes a photovoltaic station. The need to pump mine waters is caused by the danger of flooding large areas. The introduction of a photovoltaic station to power underground pumps reduces electricity consumption from the central power grid. At the same time, it changes the operating conditions of the metering unit. There is a need to measure both the currents of the pumps in the absence of solar generation, as well as relatively small current flows in the case of commensurate capacities generated and consumed within the microgrid. A feature of electromagnetic current transformers is a decrease in the accuracy of operation if the primary current is several percent of the rated value. Based on the analysis of variance of the experimental data, it was established that there is a statistically significant connection between the secondary and primary currents of the measuring transformer at insignificant values of the primary current. Estimates of the values of the linear regression parameters that link the secondary and primary currents were determined. It was established that in the range of the transformer primary current from 0.22 % to 1.4 %, the current error reaches a value of 6.7 %. Taking into account the resulting dependence in the software of the electricity metering unit will make it possible to increase the accuracy of energy metering. Accordingly, the accuracy of financial calculations will be increased
Finding God’s Way: Spiritual Well-Being on the People Who Do Tirakat Mlaku
Authors: Himawanti Izza , Hamzah Imam Faisal , Faiq Muhammad 
Published: November 2022

One of the ways to get closer to God is to escape from the world's temptations by going on a journey (safar, mlaku). This study aims to uncover the meaning of spiritual well-being in individuals who perform tirakat mlaku. This article is qualitative research with a phenomenological approach. The subject of this study is the congregation (jemaat) of Sheikh Abdullah Ibn Mas'ud Sukabumi, who perform tirakat mlaku. Data were collected through semi-structured interviews and using interpretive phenomenological analysis. This study found that there are three meanings for those who undergo tirakat mlaku: (1) quality of life, (2) social well-being, and (3) environment well-being. This study also reveals that spiritual well-being is an interrelationship between one's relationship with God, subjective well-being, and socio-environment well-being. This article provides a new perspective on the concept of tirakat as a path to closeness to God, directly affecting the quality of life, social life, and environmental protection.Contribution: The results of this study can be used as a guide in constructing the dimension of spiritual well-being in the context of Islamic psychological theory. While practically, it provides an outlook of the meanings of divinity that are implemented in social activities.
Statistical Inferences of HIVRNA and Fracture Based on the PAK1
Expression via Neural Network Model
Authors: Yuan Zheng , Ma Rui , Zhang Qiang , Zhao Chang-song 
Published: November 2022

Background:
Acquired immune deficiency syndrome and fracture are all serious hazards
to human health that create a widespread alarm. Biomarkers that are closely linked to HIVRNA and
fracture are unknown.

Methods:
48 cases with HIV and fracture and 112 normal cases were recruited. Blood neutrophil
count (NEU), white blood cell count (WBC), PAK1 and HIVRNA were measured. Pearson's chisquared
test was used to evaluate the association between HIVRNA with fracture and NEU, WBC,
PAK1. BP neural network model was constructed to analyze the predictive power of the combined
effects of NEU, WBC, PAK1 for HIV RNA with fracture.

Results:
There exist strong correlations between PAK1, NEU, WBC and HIVRNA with fracture.
The neural network model was successfully constructed. The overall determination coefficients of
the training sample, validation sample, and test sample were 0.7235, 0.4795, 0.6188, 0.6792, respectively,
indicating that the fitting effect between training sample and overall was good. Statistical
determination coefficient of the goodness of fit R2 ≈ 0.82, it can be considered that degree of fit
between the estimate and corresponding actual data is good.

Conclusion:
HIVRNA with fracture could be predicted using a neural network model based on
NEU, WBC, PAK1. The neural network model is an innovative algorithm for forecasting HIVRNA
levels with fracture.