bluuebunny/crossref_metadata_2025_split huggingface dataset:
A coordinate-free approach to the design of generalized Griffis-Duffy platforms
Authors: Shen Chengwei , Pei Xu , Hang Lubin , Yu Jingjun 
Published: August 2022

Abstract
Parallel manipulators remaining permanently in a singularity are beneficial for linear-to-rotary motion conversion. The Griffis-Duffy (GD) platform is mobile structure which can admit a Bricard motion. In this paper, we present a coordinate-free approach to the design of generalized GD platforms, which consists in determining the shape and attachment of both the moving platform and the fixed base. The generalized GD platform is treated as a combination of six coaxial single-loop mechanisms under the same constraints. Owing to the inversion, which is hidden in the geometric structure of these single-loop mechanisms, the mapping from a line to a circle establishes the geometric transformation between the fixed base and the moving platform based on the center of inversion. Moreover, the center of inversion not only identifies the location of rotation axis, but also affects the shape of the generated platform. The graphical construction of generalized GD platforms using inversion, proposed in the paper, provides geometrically feasible solutions of the manipulator for the requirement of the location of rotation axis.
Discovery of a bright-dark binary galaxy in a nearby galaxy group
Authors: Xu Jin-Long , ZHU Ming , Jiang Peng , Yu Naiping , Zhang Chuan-Peng , Liu Xiao-Lan , Wang Jie 
Published: August 2022

Abstract
One of the puzzles in extragalactic astronomy is the number disparity between the standard cold dark matter (CDM) predictions of low-mass dwarf galaxy and observations. It is often referred to as the missing satellite problem. With a large amount of deep optical surveys, the disparity has considerably decreased, but such problem remains open. The existence of ``dark galaxies", being gas-rich but nearly starless, can offers a standard way to explain the missing satellite problem. To date, many objects are considered as candidates of the dark galaxies, however, none of the candidates can be confirmed with solid evidence. Here we report the discovery of an optically bright-dark binary galaxy in the hub position of a filament in nearby galaxy group NGC 1023, based on HI observation using the Five-hundred-meter Aperture Spherical radio Telescope (FAST). The optically bright member of this binary is the known dwarf galaxy NGC 1023A, while the other member is a newly detected dark galaxy FAST 0240+3905. Besides, the binary galaxy shows a Keplerian rotation, implying that two members of the binary is merging. Our result suggests that even if dark galaxies exist, they can merge with other nearby galaxies in a short time scale. Being merged could provide another important clues to the missing satellite problem.
A Lightweight System for High-efficiency Edge-Cloud Collaborative Applications
Authors: Zhang Zhipeng , Ma Wenting , Li Hao , Tang Hongyi , Yuan Xiaohang , Hao Yuan , Xiao Jun , He Hongshun , Liu Wei , Zhou Zhiheng 
Published: August 2022

Abstract
With the development of IoT (Internet of Things) technology, ubiquitous IoT devices and the generated data increase the computational consumption dramatically. In industry, more and more manufacturers attempted to upgrade their manufacturing/assembly lines with sensors to achieve automated and intelligent workshops. Yet, to handle the massive and complicated data generated by end-point devices, technical companies started to utilize edge computing and artificial intelligence (AI). However, the shortcomings of AI in computing efficiency have become an obstacle when applying AI to edge devices. The majority of production systems need to run multiple applications for different detection tasks simultaneously. These tasks require edge nodes capable of managing threads/processes at the least cost to save computational consumption as much as possible. Thus, it is of great significance to improve the edge computing system whilst the presence of performance requirements and the limited computing resources. We intended to tackle the issues by focusing on optimizing the system structure and the complexity of the AI models. First and foremost, we proposed a distinctive cloud-edge collaborative framework composed of one universal block (UB) deployed on the edge devices and multiple parallel task-specific blocks (TSBs) on the cloud servers. This framework makes it possible to only deploy low-cost edge devices on the spots. To cooperate with the edge-cloud framework, we also introduced a pruning method that can reduce the model parameters without lowering the performance, making the system more efficient.
Transplantation of human umbilical cord mesenchymal stem cells induces angiogenesis and promotes repair of uterine scars in rats
Authors: shen xiuyin , Luo Xin , Wu Shuzhen , Wan Yingchun , Ma Huiting , Ye Shaoxin , Zhang Zhuoling , Lu Min , Tang Hai , Gou Xiaoyan , Guo Xiaoling , Liu Zhengping 
Published: August 2022

Abstract
Background
Uterine scar after cesarean section (CS) is an important cause of intrauterine adhesion, amenorrhea, uterine rupture, and infertility in females. Disruptions of angiogenesis play a critical role in the healing of uterine scars. In this study, we investigated the effects of human umbilical cord mesenchymal stem cells (hUC-MSCs) on angiogenesis regeneration in uterine scars in rats following full-thickness excision of uterine walls.
Methods
Approximately 2.0 cm was excised along the uterine wall in each uterine horn to establish a rat model of uterine scars. Hematoxylin and eosin (H&E) staining was applied to observe the tissue structure. Masson trichrome staining was used to reveal collagen deposition. Angiogenesis factors (FGF-2, VEGFA, and PDGFB) were detected via western blotting. The fate of transplanted hUC-MSCs was assessed using in vivo fluorescence imaging. The differential expression of microRNA and function prediction was detected using high-throughput sequencing.
Results
hUC-MSCs significantly improved the morphology of the tissue structure and alleviated fibrosis in general on days 15, 30, and 60 of transplantation in the hUC-MSC groups. Moreover, the expressions of all three angiogenesis factors were increased at days 15 and 30 post-transplantation. In GFP analyses, although hUC-MSCs were observed on the uterine wall at days 15 and 30, those signals gradually weakened and then accumulated in other organs at day 60. In addition, abundant hUC-MSC-specific microRNAs targeted the cell pathways of angiogenesis and the PI3K/AKT signaling pathway.
Conclusion
hUC-MSC transplantation contributed to the repair of uterine scars, mainly through the suppression of excessive fibrosis and the enhancement of vascular remodeling.
Clinical characteristics and prognosis analysis of uterine sarcoma: a single- institution retrospective study
Authors: Wang Fang , Dai Xinyue , Hu Xiaoli , Chen Huijun , Wang Yuanqiu 
Published: August 2022

Abstract
Background
Uterine sarcoma is a rare and aggressive malignant gynecologic malignancy, characterized by a relatively high recurrence rate and poor prognosis. The aim of this study was to investigate the clinicopathological features and explore the prognostic factors of these malignancies.
Methods
This is a single-institution, retrospective study. We reviewed the medical records of 155 patients with pathologically confirmed uterine sarcoma including uterine leiomyosarcoma (ULMS), low-grade endometrial stromal sarcoma (LG-ESS), high-grade endometrial stromal sarcoma (HG-ESS), undifferentiated uterine sarcoma (UUS) and adenosarcoma (AS) between 2006 and 2022. 112 patients operated between January 2006 and April 2019 were included in survival analysis. The current study recorded the clinicopathological data, treatments and outcomes to determine clinical characteristics and survival data.
Results
The most common histopathological type was ULMS (40.64%), followed by LG-ESS (36.13%) and HG-ESS (10.32%). The mean age at diagnosis of all patients was 49 years and 32.90% were postmenopausal. 15 patients underwent fast-frozen section, 63(54.78%) were diagnosed with malignancy, 29(25.22%) were highly suspected of malignancy that needed further clarification and 23(14.84%) patients were diagnosed as benign disease. 124(80%) patients underwent total hysterectomy (TH) and salpingo-oophorectomy. The multivariate analyses showed that Histological types and tumor size were independent prognostic factors both for overall survival (OS) and progression-free survival (PFS). Tumor stage was only significantly associated with PFS. Elevated preoperative NLR, PLR and postmenopausal status were significantly correlated with shorter PFS and OS in univariate analysis, but no statistically significant difference was found in multivariate analysis.
Conclusions
In patients with uterine sarcoma, in comparison to LMS and LG-ESS, UUS and HG-ESS tend to present as more aggressive tumors with poorer outcomes. Furthermore, larger tumor (> 7.5cm) was an important predictor for shorter PFS and OS.
Are Chinese sexual minority youth at a disadvantage in accessibility to sexual and reproductive health services? Findings from a national survey
Authors: Liang Yun , Hee Jiayi , Peng Chunxiao , Li Chunyan , Cao Wenzhen , Tang Kun 
Published: August 2022

Abstract
Background
Little is known about the accessibility to general sexual and reproductive health (SRH) services among sexual and gender minority communities in China, where gender- and sexuality-related stigma and discrimination remains high. The aim of this study is to investigate the accessibility to SRH services among Chinese sexual minority youths (SMY) aged 15–24 years old.
Methods
This cross-sectional study utilizes data on 54,580 youths from the 2019–2020 National College Student Survey on Sexual and Reproductive Health, conducted across 31 provinces in mainland China. Multivariable logistic regression modelling was conducted to assess the accessibility to SRH services among Chinese youth with different self-reported sexual orientation.
Results
A total of 77.6% of respondents self-identified as heterosexual, while 2.8% identified as lesbian or gay, and 9.0% as bisexual. Accessibility to free condoms at formal health services (OR 1.62, 95% CI: 1.32–1.99) and medical treatment (OR 1.83, 95% CI: 1.26–2.63) were significantly higher among gay men compared to heterosexual men. Gay men (OR 1.38, 95% CI: 1.13–1.68) and bisexual men (OR 1.33, 95% CI: 1.03–1.71) were more likely to use condom at first sexual intercourse compared to heterosexual men. However, the associations were reversed among female respondents.
Conclusions
Although SMY reported higher SRH services utilization compared to their heterosexual counterparts, the accessibility to SRH services remains low among Chinese youths. Policymakers should focus on improving the accessibility to SMY-friendly SRH services among Chinese youths.
Assessment of mechanisms underlying flyash-mediated control of oxidative stress and antioxidant metabolism in Vicia faba L.
Authors: Hussain Alisha , faizan Shahla , Bushra Sayyada 
Published: August 2022

Abstract

Globally, increasing coal-fired power production has resulted in large accumulations of coal combustion byproducts such as fly ash, widely recognized as a valuable soil ameliorant. Taking into account bakla (Vicia faba L.) in greenhouse experiments, this study aimed to assess the effects of soils amended with fly ash (FA; 0% 5%, 10%, 20%, 30%, 40% and 50%) on the plant growth characteristics and the major photosynthesis variables [(including chlorophyll content; stomatal behavior; activity of carbonic anhydrase (CA), a chloroplast-localized metalloenzyme)]; activity of nitrate reductase (NR), a rate-limiting enzyme of nitrogen metabolism; damage indicators [reactive oxygen species (ROS); and malondialdehyde (MDA), a lipid peroxidation product; and cell viability); and also to evaluate the role of defense characteristics such as proline (a nitrogenous osmolyte), and the major enzymes involved in dismutation of superoxide (superoxide dismutase, SOD); metabolism of H2O2–metabolism (catalase, CAT), and in peroxide-cleaving redox reactions (peroxidase, POX). Measurements were done at 45 days after sowing (DAS). Among the FA-proportions tested, 40 and 50% FA caused significant decreases in plant growth characteristics namely shoot length, root length, plant fresh and dry weight, and leaf area; photosynthesis variables including chlorophyll content, stomatal behavior (aperture size, shape and frequency of stomata); activity of CA and NR, and the viability of cells. These decreases in the mentioned parameters were corroborated with increases in ROS and MDA contents. However, when grown in soils amended with 5%, 10%, 20% and 30% FA, V. faba plants exhibited improvements in the mentioned parameters of growth and photosynthesis, and stomata; and cell viability; which were accompanied with the decreased contents of ROS and MDA, and coordinated increases in the activity of SOD, CAT and POX. Given the protective role of lower concentrations of FA (5%, 10%, 20% and 30%) in V. faba, these FA concentrations may be utilized as a fertilizer in sustainably improving the health and productivity of vegetable crops.
Effects of glutathionylation on guanylyltransferase activity of NS5 N-terminal capping domain from dengue, Japanese encephalitis and zika viruses
Authors: Saisawang Chonticha , Reamtong Onrapak , Nachampa Isara , Petcharat Patchareebhorn , Priewkhiew Suphansa , Wongsantichon Jantana , Ketterman Albert J. 
Published: August 2022

Abstract
Three arboviruses, dengue virus, Zika virus and Japanese encephalitis virus, have wide distribution putting millions of people at risk of infection. These three flaviviruses show evolutionarily conserved features for the viral proteins, which consist of seven non-structural and three structural proteins. Non-structural protein 5 (NS5) is important for viral replication as it possesses multiple functions including both enzyme and non-enzyme roles. Oxidative stress induced by virus infection triggers glutathionylation of cell proteins. This study was to identify the effects of modification by glutathionylation on the guanylyltransferase activity of NS5 and identify the cysteine residues modified for the three flavivirus NS5 proteins. We found the three flavivirus proteins behaved in a similar fashion with increasing glutathionylation yielding decreasing guanylyltransferase activity. The three proteins also possessed conserved cysteines and these appeared to be modified for all three proteins. The glutathionylation appears to induce conformational changes that affect enzyme activity but possibly also create binding sites for host cell protein interactions that occur at later stages of viral propagation.
Inverse association between Helicobacter pylori infection and childhood asthma in a physical examination population: a cross- sectional study in Chongqing, China
Authors: Wang Donghai , Chen Yuxia , Ding Yuan , Tu Jinwei 
Published: August 2022

Abstract
Background: Childhood asthma has substantial effects on children’s health. It is important to identify factors in early life that influence childhood asthma. Accumulating evidence indicates that Helicobacter pylori may protect against allergic diseases. This study aimed to evaluate the relationship between H. pylori infection and pediatric asthma in Chongqing, China.Materials and Methods: This cross-sectional study included healthy children aged 4–18 years who underwent a 13C urea breath test during medical checkups in 2021. All medical information was extracted from electronic medical records and a big data system. Logistic regression was used to evaluate the association between H. pylori infection and pediatric asthma, and multivariate regression models were adjusted for covariates.Results: In our study, 2241 participants, including 1240 boys (55.33%) and 1001 girls (44.67%), underwent urea breath testing (average age: 8.67 ± 2.70 years). Among them, 292 (13.03%) were positive for H. pylori and 152 (6.78%) had asthma. The rates of asthma diagnosis in H. pylori-negative and -positive children were 7.23% and 3.77%, respectively (odds ratio = 1.995; 95% confidence interval: 1.003–3.968; P < .05). Furthermore, family history of asthma and the percentage of eosinophils in routine blood examination were associated with childhood asthma; however, the body mass index, platelet count, and serum vitamin D level were not.Conclusions: We demonstrated a significant inverse association between H. pylori infection and pediatric asthma in Chongqing, China. Further studies are required to determine the causal association and underlying mechanisms to prevent and control childhood asthma
Desiccation tolerance limits, seed longevity in hermetic seed conservations in Acid Lime (Citrus aurantifolia Swingle)
Authors: H.M. Pallavi , Dhananjay B , Patil Bapurayagouda , GN Anand , KJ Sowmya 
Published: August 2022

Abstract
Storage capability of acid lime seeds are under question due to its intermediate to recalcitrant nature. Seed desiccation tolerance limits plays major role in storage of seeds with better viability for propagation in citrus. An experiment was conducted to explore the effect of desiccation limits on germination, influence of storage conditions on seed viability. Fresh seeds of kagzi acid lime investigated showed as the moisture content was reduced from 50.06% to 11.97%, the mean germination percentage was also reduced from 85.25% to 38.50% indicating sensitivity to desiccation tolerance and exhibited recalcitrant to intermediate storage behavior. The experiments on storage conditions results showed that seeds packed in aluminum foil and stored at 100C retained higher germination (62%) and seedling growth parameters up to 3 weeks of storage.
Dexmedetomidine attenuates acute stress-impaired learning and memory in mice by maintaining the homeostasis of intestinal flora
Authors: Hu Xing , Lin Yizi , Xiao Jingni , Dai Chao , Hu Zhaolan , Xie Hebin , Qin Jiao , Chen Li 
Published: August 2022

Abstract
Dexmedetomidine (Dex) has been used in surgery to improve patients' postoperative cognitive function. However, the role of Dex in stress-induced anxiety-like behaviors and cognitive impairment is still unclear. In this study, we tested the role of Dex in anxiety-like behavior and cognitive impairment induced by acute restrictive stress, and analyzed the alterations of the intestinal flora to explore the possible mechanism. Behavioral and cognitive tests, including open field test, elevated plus-maze test, novel object recognition test, Barnes maze test, were performed. Intestinal gut Microbe 16S rRNA sequencing was analyzed. We found that intraperitoneal injection of Dex significantly improved acute restrictive stress-induced anxiety-like behavior, recognition, and memory impairment. By the analysis of intestinal flora, we found that acute stress caused intestinal flora disorder in mice. Dex intervention changed the composition of the intestinal flora of acute stress mice, stabilized the ecology of the intestinal flora, and significantly increased the levels of Blautia and Coprobacillus. These findings suggest that Dex may inhibit the release of inflammatory factors through the intestinal flora and ultimately improving acute stress-induced cognitive impairment.
Study of Dielectric and Thermodynamic properties of Aqueous Glycine
Authors: Alwaleedy Suad , Mohemmed Saeed , Karale Ravikant , Kumbharkhane Ashok C. , Roy Bunty Rani , Sarode Arvind V. 
Published: August 2022

Abstract
Dielectric and thermodynamic properties of aqueous glycine having molecular weight 75.07 g/mol have been studied at different concentrations in the range 0.459 to 1.480 mol/kg in the temperature range of 298.15–278.15 K. Time Domain Reflectometery technique was used in the frequency range of 10 MHz to 30 GHz. Havriliak-Nigami equation was used to analyze the frequency dependence of the complex permittivity spectra. Two relaxation processes have been detected for studied system which requires two Debye relaxation model to describe the complex permittivity spectra 𝛆*(v). The low frequency relaxation process is associated with glycine molecules called β-relaxation while the high frequency relaxation process is associated with water molecules called γ-relaxation. For β –process, relaxation time was observed to be increasing towards lower temperature and higher concentration, which is associated with the rotational motion of glycine molecules in the surrounding of water. Relaxation strength was also observed to be increasing towards low temperature and high concentration, relaxation time and relaxation strength for γ- process was found almost independent of temperature. The study also covers solvation dynamics of glycine through the observed hydration number (Nhyd) and the effective hydration number (Zib). The effective dipole moment has been obtained using Cavell equation in order to see the effect of temperature and concentrations on the dipole moment and ultimately the dielectric constant of the solute molecules. The nature of the molecular interactions in pure liquid and liquid mixtures can be well understood in terms of thermodynamic functions. Thermo dynamical parameters such as molal entropy (∆S), molal enthalpy (∆H) and molal free energy (∆F) in addition to activation entropy, enthalpy and free energies have also been calculated in order to support the obtained dielectric parameters.
Alignment of CCI total ankle replacements in relation to midterm functional outcome and complication incidence.
Authors: Hermus Joris Petrus Sebastiaan , Kuijk Sander van , Witlox Adhiambo , Poeze Martijn , Rhijn Lodewijk W van , Arts Chris 
Published: August 2022

Abstract
Background: Total ankle arthroplasty is increasingly used as a treatment for endstage ankle arthropathy. The aim of our study was to report the mid-term clinical function and survival results of Ceramic Coated Implant (CCI) ankle replacements and assess the association between the alignment of the CCI total ankle replacements and early functional outcome and complication incidence.Methods: Data of 61 patients, who received 65 CCI implants between 2010 and 2016, were obtained from a prospectively documented database. Mean follow-up time was 85.2 months (range 27-99 months). Clinical function was assessed with AOFAS questionnaire and passive range of motion (ROM). Survival analysis and elaborate radiographic analysis was performed. Furthermore, complications and re-operations were recorded for all patients Results: Progression in ROM was most seen in the first 10 months from 21.8 degrees of passive range of motion preoperative to 27.6 degrees postoperative (p< 0.001), while the AOFAS gradually increased till 16 months postoperative from a mean of 40.9 points preoperative to an average of 82.5 over the whole follow up period of 7.1 years (p < 0.001). During follow-up we recorded 8 failures (12.3%) resulting in a Kaplan-Meier survival analysis of 87.7% with a median follow-up of 85.2 months. Conclusion: We observed excellent clinical results and survival after TAA with the CCI implant with only a low mid-term complication rateLevel of Evidence: Level III, prospective cohort study