bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and facilitators in the implementation of a telemedicine-based outpatient brain tumor surgery program
Authors: Mora Carla , Sampedro Isabel , Rodríguez-Caballero Angelina , Martín-Láez Rubén , Ortega-Roldán Marta , Venkatraghavan Lashmi , Fernández-Miera Manuel , Varea Mar , Pajaron-Guerrero Marcos , Esteban Jesus , Moreno Blanca , Manzano Asunción , Ruiz Isabel , Martino Juan , Zadeh Gelareh , Bernstein Mark , Velásquez Carlos 
Published: June 2022

OBJECTIVE
Despite growing evidence on the benefits of outpatient oncological neurosurgery (OON), it is only performed in a few specialized centers and there are no previous descriptions of established OON programs in Europe. Moreover, increasing application of telemedicine strategies, especially after the start of the coronavirus disease 2019 (COVID-19) pandemic, is drastically changing neurosurgical management, particularly in the case of vulnerable populations such as neuro-oncological patients. In this context, the authors implemented an OON program in their hospital with telematic follow-up. Herein, they describe the protocol and qualitatively analyze the barriers and facilitators of the development process.

METHODS
An OON program was developed through the following steps: assessment of hospital needs, specific OON training, multidisciplinary team organization, and OON protocol design. In addition, the implementation phase included training sessions, a pilot study, and continuous improvement sessions. Finally, barriers and facilitators of the protocol’s implementation were identified from the feedback of all participants.

RESULTS
An OON protocol was successfully designed and implemented for resection or biopsy of supratentorial lesions up to 3 cm in diameter. The protocol included the patient’s admission to the day surgery unit, noninvasive anesthetic monitoring, same-day discharge, and admission to the hospital-at-home (HaH) unit for telematic and on-site postoperative care. After a pilot study including 10 procedures in 9 patients, the main barriers identified were healthcare provider resistance to change, lack of experience in outpatient neurosurgery, patient reluctance, and limitations in the recruitment of patients. Key facilitators of the process were the patient education program, the multidisciplinary team approach, and the HaH-based telematic postoperative care.

CONCLUSIONS
Initiating an OON program with telematic follow-up in a European clinical setting is feasible. Nevertheless, it poses several barriers that can be overcome by identifying and maximizing key facilitators of the process. Among them, patient education, a multidisciplinary team approach, and HaH-based postoperative care were crucial to the success of the program. Future studies should investigate the cost-effectiveness of telemedicine to assess potential cost savings, from reduced travel and wait times, and the impact on patient satisfaction.
The health economic effects of an imaging technology–based telemedicine system for rural neuro-emergency patient care
Authors: Sato Hirotaka , Kinoshita Manabu , Tani Yuji , Kimura Teruo , Osanai Toshiya , Osanai Hiroaki , Ogasawara Katsuhiko 
Published: June 2022

OBJECTIVE
“Join,” an imaging technology–based telemedicine system, allows simultaneous radiological information sharing between physically remote institutions, virtually connecting advanced medical institutions and rural hospitals. This study aimed to elucidate the health economics effect of Join for neurological telemedicine in rural areas in Hokkaido, Japan.

METHODS
Information concerning 189 requests for patient transfer from Furano Kyokai Hospital, a regional rural hospital, to Asahikawa Medical University Hospital (AMUH), an advanced academic medical institution, was retrospectively collected. The Join system was established between Furano Kyokai Hospital and AMUH in February 2019. Data collected from patients between April 2017 and December 2018 were included in the non-Join group, and those collected between February 2019 and October 2020 were included in the Join group. Clinical variables, reasons for patient transfer requests, duration of hospital stay, and medical costs per patient were analyzed between these two groups. Furthermore, clinical characteristics were compared between patients who were transferred and not transferred based on Join.

RESULTS
More patients were discharged < 7 days after transfer to AMUH in the non-Join group compared with the Join group (p = 0.02). When focusing on the Join group, more patients who were not transferred were discharged < 1 week (p < 0.01). On the other hand, more patients required surgery (p = 0.01) when transferred. The ratio of patients whose medical cost was < USD5000 substantially decreased, from 33% for the non-Join group to 13% for the Join group.

CONCLUSIONS
An imaging technology–based telemedicine system, Join, contributed to reducing unnecessary neuro-emergency patient transfer in a remote rural area, and telemedicine with an integrated smartphone system allowed medical personnel to effectively triage at a distance neuro-emergency patients requiring advanced tertiary care.
Inpatient virtual shared medical appointments to improve health literacy, increase patient self-efficacy, and reduce provider burnout in acute cerebrovascular pathology patients and their caregivers: a pilot study
Authors: Mahajan Uma V. , Sharma Neha , Maynard Marquis , Kang Lei , Labak Collin M. , Raghavan Alankrita , Sajatovic Martha , Hoffer Alan , Shammassian Berje H. , Wright James M. , Zhou Xiaofei , Wright Christina Huang 
Published: June 2022

OBJECTIVE
Admission to the hospital for an acute cerebrovascular condition such as stroke or brain hemorrhage can be a traumatic and disorienting experience for patients and their family members. The COVID-19 pandemic has further intensified this experience in addition to exacerbating clinician and resident burnout. To ameliorate some of these concerns, a team of resident and medical student trainees implemented a virtual shared medical appointment (vSMA) program for inpatients with acute cerebrovascular disorders and their caregivers. The authors hypothesized that an early intervention in the form of a vSMA improves patient and caregiver health literacy and preparedness while simultaneously educating clinical trainees on effective communication skills and reducing clinician burnout.

METHODS
Patients and caregivers of admitted patients were identified through a census of neurosurgery, neurocritical care, and neurology electronic medical records. A weekly 60-minute secure virtual session consisted of introductions and a 10-minute standardized presentation on cerebrovascular disease management, followed by participant-guided discussion. Participants completed presession and postsession surveys. Through this small feasibility study data were obtained regarding present challenges, both expected and unforeseen.

RESULTS
A total of 170 patients were screened, and 13 patients and 26 caregivers participated in at least 1 vSMA session. A total of 6 different healthcare providers facilitated sessions. The vSMA program received overwhelmingly positive feedback from caregivers. Survey responses demonstrated that 96.4% of caregivers and 75% of patients were satisfied with the session, 96.4% of caregivers and 87.5% of patients would recommend this type of appointment to a friend or family member, and 88.8% of providers reported feeling validated by conducting the session. The participant group had a 20% greater percentage of patients discharged home without home needs compared to the nonparticipant group. The primary obstacles encountered included technological frustrations with the consent process and the sessions themselves.

CONCLUSIONS
Implementation of a vSMA program at a tertiary care center during a pandemic was feasible. Themes caregivers expressed on the postsession survey included better understanding of caring for a stroke patient and coping with the unpredictability of a patient’s prognosis. The pandemic has precipitated shifts toward telehealth, but this study highlights the importance of avoiding marginalization of elderly and less technologically inclined populations.
ТО THE QUESTION OF DEVELOPING ART EDUCATION IN UKRAINE: MIRGOROD ART SCHOOL AND THE FIRST YEARS OF ITS EXISTENCE
Authors: Krasyuk I.O. 
Published: June 2022

The article highlights one of the aspects of developing art education in Ukraine at the end of the 19-th and the beginning of the 20-th centuries. The detailed anafysis of researches publications in this country examines Mirgorod art school and its activities as one of the first educational establishments in the field of art, its curricula, methods of teaching art subjects.
CHEST X-RAY IN HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTED-PEDIATRICS: A CASE SERIES REVIEW
Authors: Putri Dhira Rizki , Jannah Marichatul 
Published: June 2022

In 2017,Â IndonesiaÂ had 4.950 new cases of HIV infection in pediatrics. In HIV, a chest x-ray is generally used to determine the Opportunistic Infections (OIs) to accelerate treatment. There are differences in the projections and the typical features on chest x-ray in each OI. The research aims to study the projectionsÂ and theÂ role ofÂ pediatricÂ chest x-ray examination in HIV. This is a descriptive qualitative research design with a case series.Â In this series, 5 pediatric patients with HIV infectionÂ are described with tuberculosis, pneumonia, and bronchiectasis. A chest x-ray in pediatrics is the most accessible investigation for respiratory disease and has an important role in the initial assessment and the follow-up of respiratory disease in HIV-infected children. It is recommendedÂ that a pediatric chest x-ray should be carried out with PA projection to obtain more optimal results. Pediatrics with clinical HIV infection can employ chest x-raysÂ to find typical features of bilateral hilar adenopathyÂ in cases of TB, focal and multifocal parenchymal abnormalitiesÂ in cases of pneumonia, or dilated and thickened airways that appear as ring shadows or tramwaysÂ in bronchiectasis.
THE INFLUENCE-FACTOR OF CYCLING AS PHYSICAL ACTIVITY IN ELDERLY POST COVID-19
Authors: Setiawan Cahyo , Jannah Suci Muqodimatul 
Published: June 2022

As the age increases, the number of deaths caused by Covid-19 becomes prominent. In China, 3,6% of people aged 60-69 years died, followed by 8% of those aged 70-79 years becauseÂ older people commonly experienced various comorbidities such as cardiovascular, diabetes, chronic respiratory disease, and hypertension. Therefore, if older people perform cycling consistently as an exercise, it would increase their immunity and derive long-term benefits. This study was a descriptive-quantitative study aimed to describe the factors that influence physical activity, specifically cycling, in aged-people post-Covid-19. The International Physical Activity Questionnaire (IPAQ) has been used to collect the information. The results showed that 88,6% of elderly people cycle because they know about the importance of exercise in health. In terms of age, the people aged between 55 and 60 years old were dominated by cycling with 29% of them being female.
Bifunctional gallium cation chelators
Authors: Polivanova A. G. , Solovieva I. N. , Botev D. O. , Yuriev D. Y. , Mylnikova A. N. , Oshchepkov M. S. 
Published: June 2022

Objectives. The chemistry of 67Ga and 68Ga radionuclides plays a key role in nuclear medicine for applications in radiopharmaceuticals, in particular, in noninvasive in vivo molecular imaging techniques. The use of radiometals for labeling biomolecules typically requires the use of bifunctional chelators, which contain a functional group for covalent bonding with the targeting vector in addition to the polydentate fragment coordinating the metal. The aim of the present review article is to analyze the currently accumulated experimental material on the development and application of bifunctional chelators of gallium cations in medical research, as well as to identify the main requirements for the structure of the chelator and its complexes with 68Ga, which are used to create effective Gabased pharmaceutical preparations.Results. The review analyzed macrocyclic bifunctional chelators forming stable in vivo complexes with 68Ga and acyclic chelators, whose main advantage is faster complexation kinetics due to the short half-life of 68Ga. The advantages and disadvantages of both types of ligands were evaluated. In addition, a critical analysis of the binding constants and the conditions for the formation of complexes was presented. Examples of the influence of the geometry, lipophilicity, and total charge of the metal complex on the biodistribution of target radiopharmaceuticals were also given.Conclusions. Despite the progress made in the considered areas of bifunctional chelators, the problem of correlating the chemical structure of a metal-based radiopharmaceutical with its behavior in vivo remains important. Comparative studies of drugs having an identical targeting vector but containing different bifunctional chelating agents could help further elucidate the effectof metal chelate moiety on pharmacokinetics. In order to create effective bifunctional chelating agents, it is necessary to take into account such factors as the stability and inertness of the chelator and its complexes under physiological conditions, lipophilicity, complexation kinetics, chelation selectivity, combinatoriality of the basic structure, along with economic aspects, e.g., the availability of raw materials and the complexity of the synthesis scheme.
A 60-year-old male with gradual loss of tooth surface
Authors: Ahmed Sageer , Hossain Mozammal , Parvin Chowdhury Afrina 
Published: June 2022

This article has no abstract. The first 100 words appear below:
A 60-year-old male came with complaints of a gradual loss of tooth surface structure on the upper left anterior tooth with no complaints of pain and hypersensitivity. He was very much concerned about the appearance of the tooth and developing any pathology and therefore wanted to get his tooth treated. Medical history was not contributory, proper history about foods and diet habits, occupational, para-functional, and other abnormal habits were recorded but nothing significant was notified. The only significant was the horizontal brushing technique.
Investigation of Potential Activity of Some Organic Compounds and Antiviral Drugs Against COVID-19 Based on Molecular Docking
Authors: Pal T. K. , Paul S. , Hossen J. 
Published: June 2022

The current outbreak of the COVID-19 threatens public health worldwide, and WHO declares this as a global pandemic. Effective oral drug therapy against coronavirus did not discover yet. In order to find out an effective drug, we docked 23 compounds within the active site of 6LU7 protein of coronavirus. Among all, some antivirals exhibited very promising results against coronavirus and may be considered as a potential drug for treating COVID-19 disease. Molecular docking study revealed that isovitexin and apigenin found from nishinda (Vitex sp.) as well as our newly prepared compound (E)-4-((3,5-dibromo-2-hydroxybenzylidene)amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide showed exce-llent activity as compared to danoprevir, lopinavir, remdesivir and ritonavir. Isovitexin showed a binding affinity of -8.00 kcal/mol, whereas the binding affinity of sulfonamide compound with the coronavirus protein was -7.30 kcal/mol, which was relatively high compared to other antiviral drugs. Besides, the synthesized sulfonamide compound's absorption, distribution, metabolism, excretion, and toxicity profiles were also carried out. The compound showed excellent drug-like properties and percentage of human oral absorption. Moreover, it was found to be safe for the human body in toxicological risk assessment.
Experimental Investigation on Green Synthesis of FeNPs using <i>Azadirachta indica</i> Leaves
Authors: Rathore A. , Devra V. 
Published: June 2022

In nanotechnology, developing an environmentally friendly method for synthesizing iron nanoparticles (FeNPs) is an important aspect. According to recent studies, the use of secondary metabolites from plant leaf extract has recently emerged as a novel technology for synthesizing various nanoparticles. The leaf extract of Azadirachta indica was used to synthesize iron nanoparticles in this research. The effects of reactant concentrations, reaction temperature, and pH of the solution on the synthesis process of iron nanoparticles were studied. A UV-Visible Spectrophotometer that analyzed absorbance spectra was used to monitor the formation of iron nanoparticles in dispersion. Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) characterized the morphology of iron nanoparticles, and results reveal the particles are spherical with an average size of 48 nm. The optimum conditions for synthesis are as follows: 15 % leaf extract, [FeCl3] = 1.0 mM, pH 6.0, and temperature 60 °C. The FTIR technique confirms that plant biomolecules induce the reduction of Fe3+ ions to FeNPs and act as a capping and stabilizing agent. Therefore, they have good stability for various applications.
Short term outcome of epileptic Seizure in children attending at Paediatric Neuroscience Department of Dhaka Shishu Hospital
Authors: Quaderi Humaira Rafiqa , Sarker Shaoli , Kanta Shayla Imam , Yasmeen BH Nazma 
Published: June 2022

Background : The optimal response to antiepileptic treatment is the control of seizures. In different studies, it has been shown that childhood epilepsy presents with a variable course, and approximately one-third of epilepsy experience alternating relapse and remission. Some of them do not become seizure-free, despite adequate treatment.
Objectives : This study aimed to see the short-term outcome of seizures in children with epilepsy (whether the seizure is controlled or not) and to correlate them with different predictors like socio-demographic factors, associated comorbidities, and adherence with antiepileptic drugs.
Methods : This retrospective observational study was conducted in an Epilepsy Clinic of Paediatric Neuroscience Department of Dhaka Shishu Hospital (DSH) over a period of 3 years from January 2013 to December 2015. During this period 1-year follow-up record of each patient was analyzed. Information on bio demographic data, clinical and developmental assessment done by a multidisciplinary team was analyzed.
Results : A total of 100 children who had epilepsy were included in this study. Unfavorable outcome (uncontrolled seizure) was found in children <5 years of age, children from the rural area, and those whose parents education were below secondary level (p values were 0.05, 0.03 and 0.04 respectively). Also, the unfavorable outcome was found in children who had H/O perinatal asphyxia (PNA), motor problem, and feeding problem (p-value=0.5, 0.002, 0.05 respectively). After 1 year of regular follow up milestone of development was improved in more than one 1domain in 51children. But there was no improvement found or their condition remained unchanged in 49 children.
Northern International Medical College Journal Vol. 11 No. 1 July 2019, Page 411-414
Relying on ST Segment Depression alone to Predict Ischemic Heart Disease- How Far We can Go ?
Authors: Alam Md Mashiul , Rahman Md Mukhlesur , Parvin Tanjima , Ahmed Khurshed , Habib SM Ahsan , Khaled Md Fakhrul Islam , Islam Md Azharul , Shahin Md Ahasanul Kabir , Siddiki Kamruzzaman , Amin Md Al 
Published: June 2022

Introduction: Ischemic heart disease (IHD) or coronary artery disease (CAD) has become predominant cause of death across the world and frequently stable angina, which is the most common presentation of this disease, gives hard time to reach a proper diagnosis due to duality of non-invasive testing. While Exercise Treadmill Test (ETT) is an inexpensive non-invasive modality which may have many output depending on method of interpretation, ST segment depression is much utilized but traditionally less perfect than available treadmill scores. We have compared its accuracy to Duke Treadmill Score (DTS), Simple Treadmill Score (STS) and Cleveland Clinic Score (CCS) among Bangladesh people to generate a local insight.
Objective: To estimate and compare accuracy of ST segment response, DTS, Simple Treadmill Score and Cleveland Clinic Score to predict CAD.
Method: In a cross-sectional study total 130 patients who had visited at a medical university with stable chest pain were selected according to predefined inclusion and exclusion criteria over one year. After taking proper history and physical examination their ETT report and Coronary Angiogram (CAG) finding, which were done according to indication defined by their consultants. ETT interpretation as ST segment response and treadmill scores were compared with gold standard test for CAD that is CAG. Accuracy of STdepression and treadmill scores were calculated by the formula “Accuracy = TP+TN / Total Sample”.
Result: Among the total sample (n=130) male and female were 93 & 37, respectively. Nearly half of male sample fell into 5th decade and around same portion of female sample was in 4th decade. About 58%, 28% & 14% patients came with typical, atypical & non-cardiac chest pain. As calculated with above mentioned formula accuracy of ST segment response alone to diagnose IHD came about 68.4% (p value 0.004). Similarly DTS, STS and CCS had 83.3%, 83.9% and 77.2% accuracy, respectively (p value 0.000).
Conclusion: During ETT relying on ST segment depression alone to diagnose CAD is significantly less accurate than treadmill scores namely, Duke Treadmill Score, Simple treadmill Score or Cleveland Clinic Score. Applying any of these treadmill scores during exercise test interpretation can identify ischemic heart disease patients with more accuracy.
University Heart Journal Vol. 17, No. 1, Jan 2021; 10-15
Echocardiographic Assessment of Myocardial Viability and Prediction of Left Ventricular Functional Recovery after Acute Myocardial Infarction Using Strain and Strain Rate
Authors: Mohammad Sohan Arif , Chowdhury MSI Tipu , Mohammad Iqbal Khaled , Akhter Najnin , Hasan ATM Iqbal , Ahmed Chowdhury Meshkat 
Published: June 2022

Background: Extent of viable myocardial tissue has been recognized as a major determinant of recovery of left ventricular (LV) function after myocardial infarction. The present research was aimed at assessment of myocardial viability and prediction of left ventricular functional recovery in patients after acute anterior ST-elevated myocardial infarction using Tissue Doppler strain.
Methods: In this prospective observational research, 47 patients admitted into the hospital with acute anterior ST-elevated myocardial infarction were included. All patients underwent two-dimensional and strain echocardiography within 48-72 hours of admission. Follow up two-dimensional echocardiography had performed at 6 months after baseline examination.
Results: Total 47 patients (mean age, 57±5 years) underwent two-dimensional and strain echocardiography within 48-72 hours of admission. Significant relations were observed between baseline global systolic lengthening strain and wall motion score index (r=0.67), change in left ventricular ejection fraction (LVEF, r= -.844), Global Ses (r=.441) and on admission troponin I (r =0.397). At 6-months follow-up, LV ejection fraction was reassessed. Patients with absolute improvement in LV ejection fraction ≥5% at 6-months follow-up (n=24; 51%) had a higher (more negative) baseline global Ses strain (P<0.001) and lower global systolic lengthening (P<.001). A cutoff value for baseline global systolic lengthening strain of 7.6% yielded a sensitivity of 83% and a specificity of 87% to predict LV functional recovery at 6-months follow-up.
Conclusions: Global Left ventricular strain (Ses and Systolic lengthening) early after acute anterior ST-elevated myocardial infarction reflects myocardial viability and predicts recovery of LV function at 6-monts follow-up.
University Heart Journal Vol. 17, No. 1, Jan 2021; 22-30