bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymptomatic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in adults is uncommon using rigorous symptom characterization and follow-up in an acute-care adult hospital outbreak
Authors: O’Grady Heidi M. , Dixit Devika , Khawaja Zoha , Snedeker Kate , Ellison Jennifer , Erebor Joyce , Jamieson Peter , Weiss Amanda , Salcedo Daniel , Roberts Kimberley , Wiens Karen , Etches Nicholas , Leal Jenine , Conly John M. 
Published: July 2022

AbstractAsymptomatic coronavirus disease 2019 (COVID-19) has been reported as a significant driver of COVID-19 outbreaks. Our hospital ward outbreak analysis suggests that comprehensive symptoms and signs assessment, in combination with adequate follow-up, allows a more precise determination of COVID-19 symptoms. Asymptomatic infection was quite uncommon among adults in this setting.
THE FIRST-ORDER LOGIC OF CZF IS INTUITIONISTIC FIRST-ORDER LOGIC
Authors: PASSMANN ROBERT 
Published: July 2022

AbstractWe prove that the first-order logic of CZF is intuitionistic first-order logic. To do so, we introduce a new model of transfinite computation (Set Register Machines) and combine the resulting notion of realisability with Beth semantics. On the way, we also show that the propositional admissible rules of CZF are exactly those of intuitionistic propositional logic.
Out of the depths: new records of the sea anemone Oulactis coliumensis (Riemann-Zürneck & Gallardo, 1990) in shallow waters from northern Chile and Peru
Authors: Spano Carlos A. , Carbajal Patricia , Ganga Benjamin , Acevedo Cristian , Häussermann Vreni 
Published: July 2022

AbstractNew in situ records of the sublittoral sea anemone Oulactis coliumensis (Riemann-Zürneck & Gallardo, 1990) are provided from different localities of northern Chile and Peru. Specimens were generally observed buried in shallow soft bottoms (3–25 m depth), near port cities and in areas with a high organic load. This is the first report of the species outside its type locality (off the Bay of Coliumo, Chile; ~36°S), extending its range of distribution to lower latitudes.
On what motivates us: a detailed review of intrinsicv.extrinsic motivation
Authors: Morris Laurel S. , Grehl Mora M. , Rutter Sarah B. , Mehta Marishka , Westwater Margaret L. 
Published: July 2022

AbstractMotivational processes underlie behaviors that enrich the human experience, and impairments in motivation are commonly observed in psychiatric illness. While motivated behavior is often examined with respect to extrinsic reinforcers, not all actions are driven by reactions to external stimuli; some are driven by ‘intrinsic’ motivation. Intrinsically motivated behaviors are computationally similar to extrinsically motivated behaviors, in that they strive to maximize reward value and minimize punishment. However, our understanding of the neurocognitive mechanisms that underlie intrinsically motivated behavior remains limited. Dysfunction in intrinsic motivation represents an important trans-diagnostic facet of psychiatric symptomology, but due to a lack of clear consensus, the contribution of intrinsic motivation to psychopathology remains poorly understood. This review aims to provide an overview of the conceptualization, measurement, and neurobiology of intrinsic motivation, providing a framework for understanding its potential contributions to psychopathology and its treatment. Distinctions between intrinsic and extrinsic motivation are discussed, including divergence in the types of associated rewards or outcomes that drive behavioral action and choice. A useful framework for understanding intrinsic motivation, and thus separating it from extrinsic motivation, is developed and suggestions for optimization of paradigms to measure intrinsic motivation are proposed.
Context, precision, and social perception: A sociopragmatic study
Authors: Beltrama Andrea , Solt Stephanie , Burnett Heather 
Published: July 2022

AbstractIn two perception experiments we explore the social indexicality of numerical expressions, comparing the evaluation of three variants: precise (e.g. ‘forty-nine minutes’) vs. explicitly approximate (e.g. ‘about fifty minutes’) vs. underspecified (e.g. ‘fifty minutes’). We ask two questions: (i) What constellations of social meanings are associated with each of these variants? (ii) How are such indexical associations modulated by the conversational setting? We find that the choice of approximate vs. precise forms differentially impact speaker evaluation along the social dimensions of Status, Solidarity, and anti-Solidarity, with underspecified numbers showing a flexible behavior. Furthermore, these associations are to some extent affected by the conversational setting, in particular the demands on descriptive precision placed by the context and the interlocutors’ goals. These findings reveal an intimate connection between pragmatic reasoning and social perception, highlighting the importance of integrating pragmatic theory in the study of social indexicality. (Social meaning, pragmatic variation, social perception, numerals, (im)precision)*
Psychological and actual group formation: Conflict is neither necessary nor sufficient
Authors: Elad-Strenger Julia , Kessler Thomas 
Published: July 2022

AbstractConflict is neither necessary nor sufficient for the existence of groups. First, the existence of mutually supporting, rather than antagonistic, interactants is sufficient to constitute a “social group.” Second, conflict does not necessarily mark group boundaries but can also exist within an ingroup. Third, psychological representations of social groups do not only trace, but also perpetuate the existence of groups.
Societies and other kinds of social groups
Authors: Moffett Mark W. 
Published: July 2022

AbstractPeople live in distinct groups, notably territory-holding societies, whose boundaries aren't neatly defined by the traits that Pietraszewski describes for his socially aligned groups (or SAGs), as I propose calling them, which occur both within and between our societies. Although studying SAGs could prove enlightening, societies are essential human groups that likely existed long before the complex SAGs of today.
Developmental antecedents of representing “group” behavior: A commentary on Pietraszewski's theory of groups
Authors: Pun Anthea , Baron Andrew 
Published: July 2022

AbstractCentral to Pietraszewski's theory is a set of group-constitutive roles within four triadic primitives. Although some data from the developmental and biological sciences support Pietraszewski's theory, other data raise questions about whether similar behavioral expectations hold across various ecological conditions and interactions. We discuss the potential for a broader set of conceptual primitives that support reasoning about groups.
Can omega-3 fatty acids and vitamin E co-supplementation affect obesity indices?
Authors: Musazadeh Vali , Tandorost Arash , Zarezadeh Meysam , Jafarzadeh Jaber , Ghavami Zoha , Jamilian Parsa , Ostadrahimi Alireza 
Published: July 2022

Abstract: Background: Studies have shown that vitamin E as an antioxidant protects omega-3 fatty acids (FAs) from oxidation. Several studies have evaluated the effect of omega-3 FAs and vitamin E co-supplementation on obesity indices; however, the results are inconsistent. The present systematic review and meta-analysis was conducted to address the role of omega-3 FAs plus vitamin E on obesity indices. Methods: Cochrane Library, PubMed, Scopus, Embase, and Web of Science databases were searched up to February 2022. Among all of the qualified studies, 10 articles were selected. The effect size was presented as weighted mean difference (WMD) and 95% confidence interval (CI). Fixed-effects model was employed to perform meta-analysis. Subgroup analysis and publication bias assessment were carried out. Results: Ten eligible randomized controlled trials comprising 558 participants were included. The average dose of omega-3 FAs and vitamin E co-supplementation in studies was 1000–4000 mg/day and 400 IU, respectively. Intervention duration varied from 6 to 16 weeks. There was no significant effect of omega-3 and vitamin E co-supplementation on body weight (BW) (WMD=0.14 kg; 95% CI: −0.13 to 0.42; p=0.297), and body mass index (BMI) (WMD=0.08, 95% CI: −0.01 to 0.16, p=0.073). However, subgroup analysis showed that it might increase BMI in women over 50 years and if the intervention lasted more than 8 weeks. Conclusion: There was no significant impact of combined omega-3 FAs and vitamin E supplementation on BW and BMI; however, it should be noted that the intervention has an increasing impact when supplementation duration was >8 weeks and in individuals with type 2 diabetes mellitus, >50 years old, and BMI>25 kg/m2.
Description and Evaluation of an Emission‐Driven and Fully Coupled Methane Cycle in UKESM1
Authors: Folberth G. A. , Staniaszek Z. , Archibald A. T. , Gedney N. , Griffiths P. T. , Jones C. D. , O’Connor F. M. , Parker R. J. , Sellar A. A. , Wiltshire A. 
Published: July 2022

AbstractMethane (CH4) is one of the most important trace gases in the atmosphere owing to its role as an exceedingly effective greenhouse gas and atmospheric pollutant. Better understanding of the global methane cycle and its interactions with the Earth system is therefore necessary for robust future projections of anthropogenic climate change and assessments of multi‐gas mitigation strategies. Here we present a newly developed methane emission‐driven Earth system model to simulate the global methane cycle fully interactively. We provide an evaluation of methane sources and sinks and a full‐cycle methane budget and its change over the historic period. We further evaluate the methane atmospheric abundance and lifetime against available observations. The new methane emission‐driven model simulates all the components of the methane cycle within observational uncertainty. We calculate a total present‐day (2000–2009 decadal average) methane source of 591 Tg(CH4) yr−1 with 197 Tg(CH4) yr−1 coming from wetlands. These sources are nearly balanced by the global methane sinks amounting to 580 Tg (CH4) yr−1; reaction of methane with the hydroxyl radical in the troposphere alone removes 525 Tg(CH4) yr−1. The imbalance between sources and sinks of 11 Tg(CH4) yr−1 represents the atmospheric methane growth rate and is in fairly good agreement with current best estimates of 5.8 Tg(CH4) yr−1 with a range of 4.9–6.6 Tg(CH4) yr−1. At present‐day the model shows a maximum systematic negative‐bias of approximately 200 ppb in the methane surface mole fraction.
Skillful Long‐Lead Prediction of Summertime Heavy Rainfall in the US Midwest From Sea Surface Salinity
Authors: Li Laifang , Schmitt Raymond W. , Ummenhofer Caroline C. 
Published: July 2022

AbstractSummertime heavy rainfall and its resultant floods are among the most harmful natural hazards in the US Midwest, one of the world's primary crop production areas. However, seasonal forecasts of heavy rain, currently based on preseason sea surface temperature anomalies (SSTAs), remain unsatisfactory. Here, we present evidence that sea surface salinity anomalies (SSSAs) over the tropical western Pacific and subtropical North Atlantic are skillful predictors of summer time heavy rainfall one season ahead. A one standard deviation change in tropical western Pacific SSSA is associated with a 1.8 mm day−1 increase in local precipitation, which excites a teleconnection pattern to extratropical North Pacific. Via extratropical air‐sea interaction and long memory of midlatitude SSTA, a wave train favorable for US Midwest heavy rain is induced. Combined with soil moisture feedbacks bridging the springtime North Atlantic salinity, the SSSA‐based statistical prediction model improves Midwest heavy rainfall forecasts by 92%, complementing existing SSTA‐based frameworks.
Intelligent wireless walls for contactless in-home monitoring
Authors: Usman Muhammad , Rains James , Cui Tie Jun , Khan Muhammad Zakir , Kazim Jalil ur Rehman , Imran Muhammad Ali , Abbasi Qammer H. 
Published: July 2022

AbstractHuman activity monitoring is an exciting research area to assist independent living among disabled and elderly population. Various techniques have been proposed to recognise human activities, such as exploiting sensors, cameras, wearables, and contactless microwave sensing. Among these, the microwave sensing has recently gained significant attention due to its merit to solve the privacy concerns of cameras and discomfort caused by wearables. However, the existing microwave sensing techniques have a basic disadvantage of requiring controlled and ideal settings for high-accuracy activity detections, which restricts its wide adoptions in non-line-of-sight (Non-LOS) environments. Here, we propose a concept of intelligent wireless walls (IWW) to ensure high-precision activity monitoring in complex environments wherein the conventional microwave sensing is invalid. The IWW is composed of a reconfigurable intelligent surface (RIS) that can perform beam steering and beamforming, and machine learning algorithms that can automatically detect the human activities with high accuracy. Two complex environments are considered: one is a corridor junction scenario with transmitter and receiver in separate corridor sections and the other is a multi-floor scenario wherein the transmitter and receiver are placed on two different floors of a building. In each of the aforementioned environments, three distinct body movements are considered namely, sitting, standing, and walking. Two subjects, one male and one female perform these activities in both environments. It is demonstrated that IWW provide a maximum detection gain of 28% in multi-floor scenario and 25% in corridor junction scenario as compared to traditional microwave sensing without RIS.
Low-loss microwave photonics links using hollow core fibres
Authors: Zhang Xi , Feng Zitong , Marpaung David , Fokoua Eric Numkam , Sakr Hesham , Hayes John Richard , Poletti Francesco , Richardson David John , Slavík Radan 
Published: July 2022

AbstractThere are a host of applications in communications, sensing, and science, in which analogue signal transmission is preferred over today’s dominant digital transmission. In some of these applications, the advantage is in lower cost, while in others, it lies in superior performance. However, especially for longer analogue photonics links (up to 10 s of km), the performance is strongly limited by the impairments arising from using standard single-mode fibres (SSMF). Firstly, the three key metrics of analogue links (loss, noise figure, and dynamic range) tend to improve with received power, but this is limited by stimulated Brillouin scattering in SSMF. Further degradation is due to the chromatic dispersion of SSMF, which induces radio-frequency (RF) signal fading, increases even-order distortions, and causes phase-to-intensity-noise conversion. Further distortions still, are caused by the Kerr nonlinearity of SSMF. We propose to address all of these shortcomings by replacing SSMFs with hollow-core optical fibres, which have simultaneously six times lower chromatic dispersion and several orders of magnitude lower nonlinearity (Brillouin, Kerr). We demonstrate the advantages in this application using a 7.7 km long hollow-core fibre sample, significantly surpassing the performance of an SSMF link in virtually every metric, including 15 dB higher link gain and 6 dB lower noise figure.
Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study
Authors: Du Preez Andrea , Lefèvre-Arbogast Sophie , González-Domínguez Raúl , Houghton Vikki , de Lucia Chiara , Low Dorrain Y. , Helmer Catherine , Féart Catherine , Delcourt Cécile , Proust-Lima Cécile , Pallàs Mercè , Sánchez-Pla Alex , Urpi-Sardà Mireia , Ruigrok Silvie R. , Altendorfer Barbara , Aigner Ludwig , Lucassen Paul J. , Korosi Aniko , Manach Claudine , Andres-Lacueva Cristina , Samieri Cécilia , Thuret Sandrine 
Published: July 2022

AbstractEnvironmental factors like diet have been linked to depression and/or relapse risk in later life. This could be partially driven by the food metabolome, which communicates with the brain via the circulatory system and interacts with hippocampal neurogenesis (HN), a form of brain plasticity implicated in depression aetiology. Despite the associations between HN, diet and depression, human data further substantiating this hypothesis are largely missing. Here, we used an in vitro model of HN to test the effects of serum samples from a longitudinal ageing cohort of 373 participants, with or without depressive symptomology. 1% participant serum was applied to human fetal hippocampal progenitor cells, and changes in HN markers were related to the occurrence of depressive symptoms across a 12-year period. Key nutritional, metabolomic and lipidomic biomarkers (extracted from participant plasma and serum) were subsequently tested for their ability to modulate HN. In our assay, we found that reduced cell death and increased neuronal differentiation were associated with later life depressive symptomatology. Additionally, we found impairments in neuronal cell morphology in cells treated with serum from participants experiencing recurrent depressive symptoms across the 12-year period. Interestingly, we found that increased neuronal differentiation was modulated by increased serum levels of metabolite butyrylcarnitine and decreased glycerophospholipid, PC35:1(16:0/19:1), levels – both of which are closely linked to diet – all in the context of depressive symptomology. These findings potentially suggest that diet and altered HN could subsequently shape the trajectory of late-life depressive symptomology.
Epigenetic signatures in antidepressant treatment response: a methylome-wide association study in the EMC trial
Authors: Engelmann J. , Zillich L. , Frank J. , Wagner S. , Cetin M. , Herzog D. P. , Müller M. B. , Tadic A. , Foo J. C. , Sirignano L. , Braus D. F. , Dahmen N. , Sordon S. , Riemenschneider M. , Spaniol C. , Gasparoni G. , Rietschel M. , Witt S. H. , Lieb K. , Streit F. 
Published: July 2022

AbstractAlthough the currently available antidepressants are well established in the treatment of the major depressive disorder (MDD), there is strong variability in the response of individual patients. Reliable predictors to guide treatment decisions before or in an early stage of treatment are needed. DNA-methylation has been proven a useful biomarker in different clinical conditions, but its importance for mechanisms of antidepressant response has not yet been determined. 80 MDD patients were selected out of >500 participants from the Early Medication Change (EMC) cohort with available genetic material based on their antidepressant response after four weeks and stratified into clear responders and age- and sex-matched non-responders (N = 40, each). Early improvement after two weeks was analyzed as a secondary outcome. DNA-methylation was determined using the Illumina EPIC BeadChip. Epigenome-wide association studies were performed and differentially methylated regions (DMRs) identified using the comb-p algorithm. Enrichment was tested for hallmark gene-sets and in genome-wide association studies of depression and antidepressant response. No epigenome-wide significant differentially methylated positions were found for treatment response or early improvement. Twenty DMRs were associated with response; the strongest in an enhancer region in SORBS2, which has been related to cardiovascular diseases and type II diabetes. Another DMR was located in CYP2C18, a gene previously linked to antidepressant response. Results pointed towards differential methylation in genes associated with cardiac function, neuroticism, and depression. Linking differential methylation to antidepressant treatment response is an emerging topic and represents a step towards personalized medicine, potentially facilitating the prediction of patients’ response before treatment.
G-CSF plus azacitidine versus azacitidine alone for patients with high-risk myelodysplastic syndrome: academic, open label, randomized trial
Authors: Stopka Tomáš , Minařík Lubomír , Dusilková Nina , Pešta Michal , Kulvait Vojtěch , Špaček Martin , Zemanová Zuzana , Kalousová Marta , Jonášová Anna 
Published: July 2022

Trial registration
GA trial is registered under EudraCT#: 2013-001639-38.
Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway
Authors: Marinello Jessica , Arleo Andrea , Russo Marco , Delcuratolo Maria , Ciccarelli Francesca , Pommier Yves , Capranico Giovanni 
Published: July 2022

Abstract
Background
Current immunotherapy strategies have contrasting clinical results in human lung cancer patients as small-cell lung cancers (SCLC) often show features of immunological cold tumours. Topoisomerase 1 (TOP1) poisons are effective antitumor drugs with good efficacy against lung cancers.

Methods
We used molecular, genetic and bioinformatic approaches to determine the mechanism of micronuclei formation induced by two TOP1 poisons in different human cancer cells, including SCLC cell lines.

Results
TOP1 poisons stimulate similar levels of micronuclei in all tested cell lines but downstream effects can vary markedly. TOP1 poisons increase micronuclei levels with a mechanism involving R-loops as overexpression of RNaseH1 markedly reduces or abolishes both H2AX phosphorylation and micronuclei formation. TOP1 poison-induced micronuclei activate the cGAS/STING pathway leading to increased expression of immune genes in HeLa cells, but not in human SCLC cell lines, mainly due to lack of STING and/or cGAS expression. Moreover, the expression of STING and antigen-presenting machinery genes is generally downregulated in patient tumours of human lung cancer datasets.

Conclusions
Altogether, our data reveal an immune signalling mechanism activated by TOP1 poisons, which is often impaired in human SCLC tumours.
CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk
Authors: Chen Yi , Zhang Yang , Wang Zhihua , Wang Yewei , Luo Yujiao , Sun Nannan , Zheng Shasha , Yan Wenzhe , Xiao Xiang , Liu Sufang , Li Ji , Peng Hongling , Xu Yunxiao , Hu Guoyu , Cheng Zhao , Zhang Guangsen 
Published: July 2022

AbstractHerein, we describe the clinical and hematological features of three genetically related families predisposed to myeloproliferative neoplasms (MPNs). Using whole-exome sequencing, we identified a c.1367delG mutation(p.Arg456fs) in CHST15 (NM_001270764), a gene encoding a type II transmembraneglycoproteinthat acts as a sulfotransferase and participates in the biosynthesis of chondroitin sulfate E, in germline and somatic cells in familial MPN. CHST15defects caused an increased JAK2V617F allele burden and upregulated p-Stat3 activity,leading to an increase in the proliferative and prodifferentiation potential of transgenic HEL cells. We demonstrated that mutant CHST15 is able to coimmmunoprecipitate the JAK2 protein,suggesting the presence of a CHST15-JAK2-Stat3 signaling axis in familial MPN. Gene expression profiling showed that the FREM1, IFI27 and C4B_2 genes are overexpressed in familial MPN, suggesting the activation of an “inflammatory response-extracellular matrix-immune regulation” signaling network in the CHST15 mutation background.We thus concluded that CHST15 is a novel gene that predisposes to familial MPN and increases the probability of disease development or transformation.