bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor Marker Decline in Predicting Treatment Outcome among Poor-Risk Testicular Germ Cell Tumors—A Tertiary Cancer Center Data
Authors: K. Lakshmi Haridas , James Francis V. , Kumar Aswin , Joseph John , KM Jagathnath Krishna 
Published: March 2022

Introduction Testicular germ cell tumors are rare in India. Despite the advances in chemotherapy, poor-risk testicular nonseminomatous germ cell tumors (NSGCT) remain as a clinical challenge. Various prognostic factors have been described in this rare disease. The Indian data in this regard is scarce. Our study is the first attempt to assess the tumor marker decline with respect to treatment outcome in poor-risk NSGCT in Indian patients.
Materials and Methods This retrospective study was done among newly diagnosed poor-risk NSGCT, treated at genitourinary clinic, at our tertiary cancer center during the period 2017 to 2019. The prognostic significance of tumor marker decline in them was correlated with 2-year progression-free survival (PFS) and 2-year overall survival (OS).
Statistical Methods The association between two variables were assessed using chi-squared/Fischer's exact test. The PFS and OS were estimated using Kaplan–Meier method and the significance difference between survival curves was tested using log rank test. The risk for survival was estimated using cox regression analysis. A p-value of <0.05 was considered as significant.
Results Out of 11 eligible patients, four (36%) had favorable tumor marker decline and seven (64%) had unfavorable decline. The 2-year PFS among favorable and unfavorable decline group were 66.7 and 42.9%, respectively (p-0.358), and the 2-year OS was 66.7 and 71.4%, respectively (p-0.974). Teratoma was not found to be a significant factor in our study. Tumors with only beta human chorionic gonadotropin (βHCG) elevation were observed to have good outcome. Postchemotherapy unresectable residual disease showed a significant trend toward inferior survival, the 2-year PFS was 38 versus 100% (p-0.188) and the 2-year OS was 62.5 versus 100% (p-0.334) in patients with and without unresectable residual disease, respectively.
Conclusion Majority of our poor-risk NSGCT patients had unfavorable tumor marker decline and progressive events. However, the survival difference was not significant, given the small sample size. Tumors with only βHCG elevation were observed to have good outcome. Postchemotherapy unresectable residual disease showed a significant trend toward inferior survival.
Student wellness trends and interventions in medical education: a narrative review
Authors: Klein Harrison J. , McCarthy Sarah M. 
Published: March 2022

AbstractMedical education is a time wrought with personal and professional stressors, posing serious challenges to maintaining student wellness. Extensive research has thus been conducted to identify these stressors and develop practical solutions to alleviate their harmful effects. This narrative review of quantitative and qualitative literature summarizes trends in student wellness and examines interventions deployed by medical schools to ameliorate student distress. Current trends indicate that mental illness, substance use, and burnout are more prevalent in medical students compared to the general population due to excessive academic, personal, and societal stressors. Pass/fail grading systems and longitudinal, collaborative learning approaches with peer support appear to be protective for student wellness. Additionally, maintaining enjoyable hobbies, cultivating social support networks, and developing resiliency decrease distress in medical students on an individual level. Faculty and administrator development is also a necessary component to ensuring student wellness. The COVID-19 pandemic has posed unique challenges to the medical education system and has stimulated unprecedented innovation in educational technology and adaptability. Particularly, the discontinuation of the clinical skill evaluation components for both osteopathic and allopathic students should be a focus of medical student wellness research in the future.
Enhanced electroresistance endurance of capped Hf0.5Zr0.5O2 ultrathin epitaxial tunnel barriers
Authors: Long Xiao , Tan Huan , Estandía Saúl , Gazquez Jaume , Sánchez Florencio , Fina Ignasi , Fontcuberta Josep 
Published: March 2022

Electroresistance in ultrathin Hf0.5Zr0.5O2 (HZO) films is pivotal toward the implementation of hafnia-based ferroelectrics in electronics. Here, we show that the electroresistance yield and endurance of large capacitors (∼314 µm2) of epitaxial HZO films only 2.2 nm thick grown on SrTiO3 or GdScO3 can be improved using 1 nm SrTiO3 capping layers. It is argued that the main role of the capping layer is to minimize charge transport along grain boundaries, and, thus, a similar strategy can be explored in polycrystalline films.
Non-Fermi liquid phase and linear-in-temperature scattering rate in overdoped two-dimensional Hubbard model
Authors: Wú Wéi , Wang Xiang , Tremblay André-Marie 
Published: March 2022

SignificanceMost metals display an electron-scattering rate1/τthat follows1/τ∼T2at low temperatures, as prescribed by Fermi liquid theory. But there are important exceptions. One of the most prominent examples is the “strange” metal regime in overdoped cuprate supercondcutors, which exhibits a linearTdependence of the scattering rate1/τ∼Tthat reaches a putative Planckian limit. Here, using cutting-edge computational approaches, we show thatT-linear scattering rate can emerge from the overdoped Hubbard model at low temperatures. Our results agree with cuprate experiments in various aspects but challenge the Planckian limit. Finally, by identifying antiferromagnetic fluctuations as the physical origin of theT-linear scattering rate, we discover the microscopic mechanism of strange metallicity in cuprates.
A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis
Authors: Park Yun Ji , Jodts Richard J. , Slater Jeffrey W. , Reyes Reyvin M. , Winton Valerie J. , Montaser Rana A. , Thomas Paul M. , Dowdle William B. , Ruiz Anahi , Kelleher Neil L. , Bollinger J. Martin , Krebs Carsten , Hoffman Brian M. , Rosenzweig Amy C. 
Published: March 2022

Significance
Methanobactins (Mbns), copper-binding peptidic compounds produced by some bacteria, are candidate therapeutics for human diseases of copper overload. The paired oxazolone-thioamide bidentate ligands of methanobactins are generated from cysteine residues in a precursor peptide, MbnA, by the MbnBC enzyme complex. MbnBC activity depends on the presence of iron and oxygen, but the catalytically active form has not been identified. Here, we provide evidence that a dinuclear Fe(II)Fe(III) center in MbnB, which is the only representative of a >13,000-member protein family to be characterized, is responsible for this reaction. These findings expand the known roles of diiron enzymes in biology and set the stage for mechanistic understanding, and ultimately engineering, of the MbnBC biosynthetic complex.
The syntax of directional Serial Verb Constructions in French-based creoles
Authors: Zribi-Hertz Anne , Jean-Louis Loïc 
Published: March 2022

Abstract
This article bears on directional Serial Verb Constructions (SVCs) in
French-based creoles. Starting with a working definition of our topic of study, we present a detailed description of the data in
Martinican Creole (MQ) – whose grammar is similar in the relevant respects to that of Haitian (HC). Four different structural
patterns are distinguished. Our results bring partial support to Aboh’s (2015)
assumption that the emergence of Haitian SVCs might have resulted from congruence between Gbe SVCs (analysed as ‘causative-like’)
and French Clause Union. We argue that this idea finds further confirmation in cross-creole comparison, but only concerns one type
of (directional) SVC.
L’oiseau-guide, de la mythologie indo-européenne à la fable du XIVe siècle
Authors: Redondo Jordi 
Published: March 2022

Résumé
Notre contribution vise à situer dans son contexte littéraire le symbolisme de l’oiseau-guide tel qu’on le trouve dans deux textes catalans caractérisés par leur étroit rapport avec la tradition occitane. Il s’agit des poèmes Frayre de joi e sor de plaser, anonyme, et de La faula de Guillem Torroella. Du point du vue aussi bien chronologique que formel, les deux poèmes offrent une composition parallèle. Le sujet dont il est question ici est la présence d’un oiseau qui guide le héros. Ce motif appartenant à la tradition poétique européenne, sa présence dans ces deux poèmes s’explique par la profonde influence de l’héritage mythologique sur les genres de la fable et le roman courtois. C’est ainsi que l’oiseau-guide se retrouve dans plusieurs récits français et occitans, notamment du cycle arthurien.
Infectious bursal disease.
Authors:   UK, CABI
Published: March 2022

Abstract

Infectious bursal disease virus (IBDV), a double stranded RNA virus belonging to the genus Avibirnavirus and family Birnaviridae, is the causative agent of infectious bursal disease (IBD) (Luque et al., 2009). IBDV shows selective tropism for lymphoid tissues especially bursa of Fabricius and causes an acute and highly contagious viral disease which is manifested with inflammation and subsequently atrophy of the bursa of Fabricius, immunosuppression and various degrees of nephroso-nephritis in chickens between 3 weeks and 3 months of age (Berg, 2000; Eterradossi and Saif, 2008; Mahgoub, 2012; Müller et al., 2012). First recognized in Gumboro, Delaware (USA) in 1962, the disease was initially referred to as avian nephrosis, and later became known as Gumboro disease or infectious bursitis. Economic losses are high and are manifested in two ways. First, in the case of classical IBD, because of high mortality in chickens of 3-6 weeks and prolonged immunosuppression leading to secondary infections and vaccination failures (Ingrao et al., 2013). The virus occurs worldwide, and despite intensive vaccination regimes, outbreaks of disease occur frequently, and various variants of IBDV occur, each with a different virulence. At the end of the 1980s, very virulent variants of IBDV (vvIBDV) emerged, initially in Europe, and subsequently in Asia, the Middle East and South America. vvIBDV may cause acute disease in susceptible flocks over the entire growing period of broilers, in which the virus invades non-bursal and haematopoietic organs, such as the thymus, spleen and bone marrow. In many cases, the classical vaccines failed to provide sufficient protection against vvIBD (Fan et al., 2020). Thus novel vaccine technologies are being applied to design more effective vaccine and vaccination strategies against vvIBDV. The aim is to develop new, tailor-made live or inactivated (subunit) vaccines that protect against both classical and vvIBDV strains. They should have the potency of 'hot' live vaccines, without the accompanying dangers of causing immunosuppression. In particular the interference of maternal derived antibodies must be overcome. The development of marker vaccines that provide the ability to distinguish between vaccinal and infectious antibodies, would allow monitoring of the epidemiological field situation (Alkie and Rautenschlein, 2016).
Generalized inexact Newton regularization for nonlinear ill-posed problems in Banach spaces
Authors: Gu Ruixue , Fu Hongsun , Han Bo 
Published: March 2022

Abstract
In this paper, we generalize inexact Newton regularization methods to solve nonlinear inverse problems from a reflexive Banach space to a Banach space. The image space is not necessarily reflexive so that the method can be used to deal with various types of noise such as the Gaussian noise and the impulsive noise. The method consists of an outer Newton iteration and an inner scheme which provides increments by applying the regularization technique to the local linearized equations. Under some assumptions, in particular, the reflexivity of the image space is not required, we present a novel convergence analysis of the inexact Newton regularization method with inner scheme defined by Landweber iteration. Furthermore, by employing a two-point gradient method as inner regularization scheme to accelerate the convergence, we propose an accelerated version of inexact Newton–Landweber method and present the detailed convergence analysis. The numerical simulations are provided to demonstrate the effectiveness of the proposed methods in handling different kinds of noise and the fast convergence of the accelerated method.
A universal dimensionless length scale in medium range order amorphous structures
Authors: Shukla Pragya 
Published: March 2022

Abstract
Our theoretical analysis reveals the existence of a previously unknown universality, namely, a dimensionless length scale, related to a ratio of medium and short range order structures of amorphous systems that originates from a conspiracy between dispersion forces among molecules and their phonon mediated coupling. The scale in turn gives rise to the structure lying underneath the low temperature universalities of many other properties e.g. specific heat, internal friction, boson peak characteristics, Meissner–Berret ratio etc.
A modified fusion model-based/data-driven model for sensor fault diagnosis and performance degradation estimation of aero-engine
Authors: Huang Yufeng , Sun Gang , Tao Jun , Hu Yan , Yuan Liuyin 
Published: March 2022

Abstract
Sensor fault diagnosis and performance degradation estimation (SFDPDE) plays a critical role in the operation and maintenance of aero-engines. In this study, a modified fusion model driven by sensor measurements is proposed to overcome the drawbacks of the single data-driven and single model-based methods. Two types of on-board models are established based on augmented state space equations, and a data-driven model based on an extreme learning machine (ELM) is constructed for residual correction of the on-board model. A bidirectional information transmission algorithm is designed in the SFDPDE framework in order to include the function coordination. The Kalman filter is employed as the optimal algorithm in the SFDPDE framework, containing a standardized sensor parameter selection process. The experimental results indicate that the proposed fusion model improves the accuracy of sensor fault diagnosis and reduces the mean square error of health parameter estimations, while the information sharing module expands the application scope of SFDPDE and improves its accuracy as well as stability.
The catalytic effect of RuM-C catalyst attached to carbon- based support for hydrogen evolution reaction
Authors: Xu Ziqi , Liu Hui , Sun Jianhang , Zhou Weiying , Han Ce , Yang Guocheng , Shan Yuping 
Published: March 2022

Abstract
The potential of converting traditional biomass into low-cost HER catalysts has broad application prospects. In this paper, fungus is used as a carbon-based carrier. The bimetallic catalyst RuM-C (M = V, Mo, W, Zn, Cu) was synthesized under inert gas protection at high temperature. The order of electrocatalytic activity is RuV-C > RuZn-C > RuW-C > RuMo-C > Ru-C > RuCu-C > BF-C, which indicates that RuV-C exhibits excellent HER activity. Due to its irregular sheet structure, the specific surface area of the catalyst is increased. Impressively, it exhibits extremely high catalytic activity for HER in 1 M KOH due to favorable kinetics and excellent specific activity. Consequently, the prepared RuV-C exhibited excellent and stable HER activity compared Ru-C with a low overpotential of 65.78 mV at the current densities of 10 mA cm−2 and Tafel slope of 45.26 mV dec−1. The potential only decreased by 88 mV after 24 h of continuous testing, which indicates that the catalyst has outstanding stability. This work will provide positive inspiration for the promotion of a new Ru-based biomass HER electrocatalyst.
Periodical discharge regime transitions under long-term repetitive nanosecond pulses
Authors: Zhao Zheng , Li Chenjie , Zheng Xinlei , Sun Anbang , Li Jiangtao 
Published: March 2022

Abstract
Intuitively, the nanosecond repetitively pulsed (NRP) corona and spark regimes are sustained successively after onsets due to the high background electron density and/or the surplus heat. In this paper, the NRP discharge unexpectedly swings among different regimes (corona → glow → spark → corona → …) in one pulse train, which is characterized by the periodical spark quench and reestablishment. We have investigated discharge regime instabilities by applying long-term repetitive high-voltage nanosecond pulses of ∼15 ns duration to needle–needle and needle–plane gaps in atmospheric-pressure N2 and N2–O2 mixtures. Pulse-sequence resolved electrical and optical diagnostics have been implemented to capture transition processes. The initial corona gradually grows into glow and then spark ‘pulse-by-pulse’, however, the spark regime was interrupted after a certain number of voltage pulses until the next reestablishment. Narrow pulse width impedes the discharge instability growth within one pulse, and a certain number of voltage pulses are required for the discharge regime transition. The addition of O2 dramatically boosts the duration length of spark regime. A lower output impedance of the power supply induces a higher deposited energy into a spark, however, not necessarily leads to a longer spark regime duration, although both the energy storage and the average electric field strength are approximate. Polarity effects, conventionally diminished in pulse-periodic discharges, are still evident during the discharge regime transition. The periodical discharge regime transition is qualitatively explained based on the plasma–source coupling and the evolution trajectory along the power transfer curve. Feedback mechanisms and residual-conductivity related screening effect in NRP spark discharges are analyzed based on a simplified 0D simulation. The periodical feature is probably caused by the insufficient average deposited energy per unit distance per one pulse cycle. In-depth understandings of ‘non-binary’ regimes (neither corona nor spark) and memory effect mechanisms of NRP discharges could be reached.
Addendum: Experimental evidence of intrabeam scattering in a free-electron laser driver (2020 New J. Phys.

22 083053)
Authors: Di Mitri S , Perosa G , Brynes A , Setija I , Spampinati S , Williams P H , Wolski A , Allaria E , Brussaard S , Giannessi L , Penco G , Rebernik P R , Trov M 
Published: March 2022

Abstract
A conceptual inaccuracy in the calculation of energy spread induced by intrabeam scattering in the presence of linear acceleration is put in evidence. A new self-consistent equation is presented. Two new solutions are provided in the approximation of Coulomb logarithm independent of the particle energy, and for a weak energy dependence. A comparison of the three solutions is shown; it does not imply any noticeable modification to the previously published data, hence the published conclusions remain valid.
Role of deposition parameters on the properties of the fabricated heterojunction ZnS/p-Si Schottky diode
Authors: Kumar Arun , Mukherjee Samrat , Sharma Himanshu , Dwivedi Umesh Kumar , Kumar Sunil , Gangwar Rajesh K , Choubey Ravi Kant 
Published: March 2022

Abstract
Heterojunction diodes of ZnS/p-Si have been fabricated using the chemical bath deposition (CBD) technique at two different deposition durations under both stirring and non-stirring conditions. The x-ray diffraction (XRD) patterns indicate the deposited ZnS films exhibit good crystallinity with the growth direction along the (111) planes of a cubic zinc blend structure. The crystallite size of all the deposited ZnS thin films have been calculated using the Scherer formula and found to be in the range of 2.2–2.7 nm which is very close (∼4 nm) to the size estimated using transmission electron microscopy (TEM). The surface morphology of the deposited ZnS thin films were studied by scanning electron microscopy (SEM) and it was observed that spherical nanoparticles agglomerated with the increase in deposition time. Furthermore, the optical properties of the deposited ZnS thin films were studied using UV-visible (UV-VIS) and photoluminescence (PL) spectroscopy. The effective calculated band gap was found in the range from 3.7–3.82 eV for all the samples, however PL spectra shows multiple emissions in the as-deposited ZnS films, indicating the presence of intrinsic defects, The characteristics of the fabricated ZnS/p-Si heterojunction diode was studied by measuring the dark current-voltage (I–V) relation using thermionic emission model. Electrical parameters such as barrier height, saturation current, ideality factor and series resistance were extracted from the I–V characteristics of the fabricated Schottky diodes. The barrier potential for all the ZnS/p-Si heterojunction diodes range between 0.829–0.857. Moreover, the calculated ideality factor was found very close to the ideal value of the diode (1.34 and 1.43) in the devices fabricated under stirring conditions.
A comprehensive study of decay modes associated with Pb isotopes
Authors: Sharma R , Jain A , Sharma P K , Jain S K , Saxena G 
Published: March 2022

Abstract
Decay modes in Pb isotopes within the range 176 ≤ A ≤ 266 are investigated by the calculation of half-lives using several empirical formulas. These formulas along with various theoretical treatments are first tested to reproduce experimental half-lives and known decay modes of Pb isotopes, which are in consequence applied to estimate half-lives and decay modes of unknown Pb isotopes. A comparison between α-decay and weak-decay from the stable to drip-line isotopes is canvassed which leads to an excellent match with experimental data and applicability of applied empirical formulas. In addition, the full chain of Pb isotopes is probed as potential daughter candidates of cluster emission from superheavy nuclei which ensued the predominant role of 208Pb and nearby isotopes in probable cluster emission.
An infinite class of exact rotating black hole metrics of modified gravity
Authors: Afonso Victor I. , Mora-Pérez Gerardo , Olmo Gonzalo J. , Orazi Emanuele , Rubiera-Garcia Diego 
Published: March 2022

Abstract
We build an infinite class of exact axisymmetric solutions of a metric-affine gravity theory, namely, Eddington-inspired Born-Infeld gravity, coupled to an anisotropic fluid as a matter source. The solution-generating method employed is not unique of this theory but can be extended to other Ricci-Based Gravity theories (RBGs), a class of theories built out of contractions of the Ricci tensor with the metric. This method exploits a correspondence between the space of solutions of General Relativity and that of RBGs, and is independent of the symmetries of the problem. For the particular case in which the fluid is identified with non-linear electromagnetic fields we explicitly derive the corresponding axisymmetric solutions. Finally, we use this result to work out the counterpart of the Kerr-Newman black hole when Maxwell electrodynamics is set on the metric-affine side. Our results open up an exciting new avenue for testing new gravitational phenomenology in the fields of gravitational waves and shadows out of rotating black holes.