bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanomedicine‐boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma
Authors: Lu Yi , Gao Yue , Yang Huan , Hu Yong , Li Xin 
Published: December 2022

AbstractTraditional treatments for advanced hepatocellular carcinoma (HCC), such as surgical resection, transplantation, radiofrequency ablation, and chemotherapy are unsatisfactory, and therefore the exploration of powerful therapeutic strategies is urgently needed. Immunotherapy has emerged as a promising strategy for advanced HCC treatment due to its minimal side effects and long-lasting therapeutic memory effects. Recent studies have demonstrated that icaritin could serve as an immunomodulator for effective immunotherapy of advanced HCC. Encouragingly, in 2022, icaritin soft capsules were approved by the National Medical Products Administration (NMPA) of China for the immunotherapy of advanced HCC. However, the therapeutic efficacy of icaritin in clinical practice is impaired by its poor bioavailability and unfavorable in vivo delivery efficiency. Recently, functionalized drug delivery systems including stimuli-responsive nanocarriers, cell membrane-coated nanocarriers, and living cell-nanocarrier systems have been designed to overcome the shortcomings of drugs, including the low bioavailability and limited delivery efficiency as well as side effects. Taken together, the development of icaritin-based nanomedicines is expected to further improve the immunotherapy of advanced HCC. Herein, we compared the different preparation methods for icaritin, interpreted the HCC immune microenvironment and the mechanisms underlying icaritin for treatment of advanced HCC, and discussed both the design of icaritin-based nanomedicines with high icaritin loading and the latest progress in icaritin-based nanomedicines for advanced HCC immunotherapy. Finally, the prospects to promote further clinical translation of icaritin-based nanomedicines for the immunotherapy of advanced HCC were proposed.
Prognostic factors in patients with septic disseminated intravascular coagulation treated with thrombomodulin: the effect of reduced thrombomodulin dose; a single-center, retrospective, observational study
Authors: Nishita Yoshihiro , Taga Masatoshi , Sakurai Masaru , Iinuma Yoshitsugu , Masauji Togen 
Published: December 2022

Abstract
Background
Human soluble recombinant thrombomodulin (TM alfa), a treatment for septic Disseminated intravascular coagulation (DIC), is recommended for patients with severe renal dysfunction in reduced doses. However, no studies have examined yet how dose reduction affects clinical efficacy. In this study, we investigated the significance of the TM alfa dose as a prognostic factor in clarifying the clinical background factors related to the clinical effect of TM alfa in patients with septic DIC.

Methods
This study involved 102 patients with septic DIC admitted to a single-center intensive care unit between April 2013 and March 2020, receiving TM alfa. The following factors were retrospectively collected from the medical records of the target patients: (1) patient background, (2) sequential organ failure assessment (SOFA) score, (3) Japanese Association for Acute Medicine DIC diagnostic criteria score, (4) DIC treatment information, (5) TM alfa dose per bodyweight (normal dose: 0.06 mg/kg or reduced dose: 0.02 mg/kg), (6) DIC resolution within 7 days after the start of TM alfa administration (DIC resolution), (7) all deaths within 30 days after the start of TM alfa administration (30-days-all-cause mortality), (8) presence or absence of new hemorrhagic side effects after the start of TM alfa administration. Multiple logistic regression analysis was used to assess factors associated with DIC resolution and 30-days-all-cause mortality.

Results
The SOFA score (odds ratio: 95% confidence interval, 0.76: 0.66–0.89), pneumonia (0.24: 0.08–0.75), and reduced dose administration of TM alfa (0.23: 0.08–0.66) were independent of and negatively related to the DIC resolution. For the 30-days-all-cause mortality, the SOFA score (1.66: 1.31–2.09), pneumonia (9.50: 2.49–36.25), and TM alfa dose reduction (3.52: 1.06–11.69) were independent, poor prognostic factors. We found no association between the hemorrhagic side effects and the TM alfa dose per bodyweight.

Conclusions
The reduced dose of TM alfa for patients with severe renal dysfunction was observed to be an influential factor for DIC resolution and 30-day all-cause mortality, as were SOFA scores and pneumonia. Further studies are required in the future to verify this finding.
Pharmacist’s interventions in factors contributing to medication errors reduces medication errors in self-management of patients in the rehabilitation ward
Authors: Suzuki Ryohei , Uchiya Takako , Sakai Takamasa , Takahashi Masaaki , Ohtsu Fumiko 
Published: December 2022

Abstract

Background
The number of medications, number of administrations per day, dosing frequency on indicated day, and medication from multiple prescriptions are the medication factors prone to medication errors in self-management that have been previously reported. However, whether pharmacists actually intervene in medication factors that affect medication error occurrences in self-management is unclear. Therefore, we conducted this study to clarify these issues.

Method
This study included patients who underwent self-management in the rehabilitation ward of Higashinagoya National Hospital. From April 2019 to March 2020, a one-pharmacist period existed, and from April 2020 to March 2021, a two-pharmacist period existed. The number of patient instructions and interventions were expected to increase with an increase in the number of pharmacists. Considering this to be an environment of differential interventions by pharmacists, a pre-post-test design was conducted with all self-managed patients in both the time periods. The primary and secondary endpoints were the proportion of medication error occurrences and proportion of pharmacist’s interventions in medication factors, respectively.

Result
The proportions of medication error occurrences during the one-pharmacist and two-pharmacist periods were 41% (71/173) and 28% (51/180) (relative risk 0.690, 95% confidential interval 0.515–0.925), respectively. The proportion of pharmacist’s interventions in medication factors in the one-pharmacist period was 13% (22/173) and 22% (40/180) in the two-pharmacist period; there was an increase in the proportion of pharmacist’s interventions in medication factors in the two-pharmacist period.

Conclusion
The proportion of medication error occurrences was significantly lower in the two-pharmacist period than that in the one-pharmacist period. This can be attributed to the increase in the proportion of pharmacist’s interventions in medication factors. Therefore, an environment in which pharmacists could intervene in the medication factors to prevent medication errors in advance is necessary.
Disparities in fruit and vegetable intake at the intersection of gender and education in northern Sweden: a cross-sectional study
Authors: Vogt Thomas , Gustafsson Per E. 
Published: December 2022

Abstract
Background
Even though the existence of inequalities in fruit and vegetable consumption has been well established, it is not clear how it is patterned across intersections of multiple social positions and identities. This study aims to investigate disparities in fruit and vegetable intake between groups at the intersection of education and gender in northern Sweden, and to estimate the discriminatory accuracy of the intersectional groups.

Methods
Cross-sectional data from the 2018 Health on Equal Terms survey conducted in four regions in northern Sweden was used (N = 21,853). Four intersectional groups were created: high and low educated men, and high and low educated women. Prevalence differences corresponding to joint, referent, and excess intersectional inequalities, were estimated for three outcomes: inadequate fruit and vegetable intake combined, inadequate fruit intake, and inadequate vegetable intake. The discriminatory accuracy of the intersectional groups was estimated by the area under the receiver operating characteristic curve.

Results
Low educated men had the highest prevalence of inadequate intake of fruits and vegetables combined (81.4%), fruits (83.4%), and vegetables (84.9%), while high educated women had the lowest (47.7, 60.2, and 51.8%, respectively). The joint disparities between high educated women and low educated men were both significant and substantial for all outcomes (34.6 percentage points (pp.), 25.2 pp., and 31.2 pp., adjusted), although differences in magnitude were noted between fruit and vegetable intake. The joint disparities were mostly explained by the two referent disparities for gender and education. The excess intersectional disparity - the part of the joint disparity not explained by either referent disparity – was negative for all three outcomes (-5.5 pp., − 4.2 pp., and − 4.6 pp. respectively, adjusted). The discriminatory accuracy of the intersectional groups was moderate (0.67, 0.65, and 0.68 respectively).

Conclusions
An intersectional approach can provide a more detailed view of inequalities in fruit and vegetable consumption between groups combining several social positions. The moderate discriminatory accuracy observed here suggests that interventions and policies aiming to reduce diet inequalities should not solely be targeted at certain groups, but also be universal.
A simple twist technique for lens-sparing one-handed peripheral vitrectomy in phakic patients: a learning approach for junior surgeons
Authors: Petrovski Goran , Lytvynchuk Lyubomyr , Stieger Knut , Petrovski David 
Published: December 2022

AbstractThe evolution of vitrectomy has led to improved suturless techniques and minimally invasive surgery. Nevertheless, the procedure requires great bimanual dexterity and poses risk for lens touch, especially in the hands of less experienced junior surgeons. We hereby present a twist technique which allows for one-handed (right or left) peripheral vitrectomy without the need for one or several hand-switches with the vitreous cutter and avoids lens touch. The technique can be used as a learning approach for junior vitreoretinal surgeons.
Hyperfunctioning parathyroid gland and skeletal involvement on [18F]fluorocholine PET/CT: one look with two views
Authors: Nappi Carmela , Piscopo Leandra , Klain Michele , Mainolfi Ciro Gabriele , Vergara Emilia , Adamo Daniela , Mignogna Michele Davide , Cuocolo Alberto 
Published: December 2022

AbstractHyperparathyroidism is an endocrine disorder that may be associated with other metabolic diseases. Non-invasive imaging techniques including [99mTc]Tc-sestamibi single-photon emission computed tomography (SPECT) and [18F]fluorocholine positron emission tomography (PET)/computed tomography (CT) play a key role on management of patients with hyperparathyroidism. We report for the first time a case of a patient with evidence of both hyperfunctioning parathyroid tissue and multiple lytic bone lesions on [18F]fluorocholine PET/CT imaging. The present case report highlights the potential role of whole-body [18F]fluorocholine PET/CT for the identification of both parathyroid adenoma and multiple bone lesions in a single diagnostic setting.
Role of GATA3 as a potential adjunct marker in the differential diagnosis of Paget’s disease of the nipple
Authors: Jovino Neves Santos Tércia , De Brot Marina , Martins Bezerra Stephania , Rodrigues Buniatti Samuel , Piana de Andrade Victor , Soares Fernando Augusto , Alves de Castro João Víctor , Bueno de Toledo Osório Cynthia Aparecida 
Published: December 2022

AbstractAimsPaget’s disease of the nipple (PDN) is a rare type of cancer of the nipple-areola complex. We examined GATA3 protein expression in PDN to determine its potential value as an adjunct marker in the differential diagnosis with other nipple lesions.Methods and resultsChart review documented clinicopathological data. H&E slides were re-evaluated and immunohistochemistry (IHC) for GATA3 was performed. Amongst 3614 breast cancer patients, 74 had PDN and 41 cases were selected for our study (mean age, 55 years). Amid PDN cases, 4 (10%) patients showed PDN alone, 22 (65%) had an underlying ductal carcinoma in situ and 15 (37%) had invasive breast carcinomas (IBC), including 11 invasive carcinoma of no special type, 2 lobular, 1 mucinous and 1 micropapillary carcinoma. Additionally, 9 cancers were classified as luminal B, 4 as HER2 overexpression and 2 as luminal A. GATA3 expression was detected in all 41 PDN cases and in all underlying cancers. Furthermore, IHC for S-100, HMB45 and Melan-A was performed in PDN-only, ensuing negative results. Positivity for cytokeratin 7 or AE1/AE3 was demonstrated in all cases and HER2 overexpression was seen in 2/4 lesions. GATA3 expression was noted in all lesions, including one CK7-negative case.ConclusionOur findings indicate that GATA3 is consistently expressed in PDN. Although not entirely specific, positivity for GATA3 reinforces the non-melanocytic nature of PDN and its mammary origin, thus representing a potential adjunct tool for the diagnosis of PDN in tricky situations, particularly PDN variants or unusual lesions.
A comprehensive bibliometric analysis of Catha edulis (Vahl) Endli (Khat) research (1961–2021)
Authors: Abdelwahab Siddig Ibrahim , Mohamed Manal Mohamed Elhassan Taha 
Published: December 2022

Abstract
Background
The use of Khat (Catha edulis) causes health, psychological, and socioeconomic burdens, and many scientific studies have been conducted on this abused plant. A careful review using bibliometric methods is required to increase the usefulness of this research and contribute to curbing the Khat problem. The main objective of this study is to evaluate the intellectual structure, diffusion of knowledge, emerging literature, and impact of collaboration in Khat research using bibliometric analysis.

Main body
The Scopus database was used to extract scientific papers published from 1961 to 2021 and search for titles and abstracts published in English. The VOSviewer software and MS Excel were used for citation, co-citation, and co-authorship analyses. Bibliographic coupling was calculated using the fractional counting method. There were 996 papers published in 60 years, 159 researchers, and 80 countries that met the criteria for inclusion. The top publishing countries, in order, are Ethiopia, the USA, Saudi Arabia, the UK, and Yemen. The USA provided the most prominent financial support for Khat’s research. 32.1% of research is in the medical field, with eleven more diverse research fields. The top-publishing researcher with the highest total link strength is Mustafa al’Absi from Minnesota Medical School, USA. A bibliometric mapping of citations revealed 113 articles with more than 50 citations, diffused across various research areas. The Journal of Ethnopharmacology is the top-cited source. Ethiopia is the most collaborative country. Molecular mechanisms of Khat toxicity on gene and protein levels are emerging. A network visualization map of terms' occurrence in titles and abstracts resulted in four research themes.

Conclusion
The current study encourages researchers from various fields to inaugurate new platforms and direct the research toward evidence-based cessation programs.
TALE-induced immunity against the bacterial blight pathogen Xanthomonas oryzae pv. oryzae in rice
Authors: Xu Xiameng , Li Ying , Xu Zhengyin , Yan Jiali , Wang Yong , Wang Yijie , Cheng Guanyun , Zou Lifang , Chen Gongyou 
Published: December 2022

AbstractTranscription activator-like effectors (TALEs) are proteins produced by plant pathogenic Xanthomonas spp. TALEs exhibit a conserved structure and have the ability to directly bind to the promoter region of host target genes where they activate transcription. TALEs in Xanthomonas oryzae pv. oryzae (Xoo), the causal agent of bacterial blight (BB) in rice, play important roles in triggering resistance (ETI) and susceptibility (ETS) for rice immunity. This review briefly describes rice resistance breeding in China, TALE properties and their roles, BB resistance (R) and susceptibility (S) genes in rice, the arms-race between TALEs and TALE-targets, and strategies for breeding disease-resistant crops. A systematic overview of the complex roles of TALEs are presented along with ongoing efforts to breed crops with durable and broad-spectrum resistance to the pathogenic bacterium.
Genomic landscape of mature B-cell non-Hodgkin lymphomas — an appraisal from lymphomagenesis to drug resistance
Authors: Panda Devasis , Das Nupur , Thakral Deepshi , Gupta Ritu 
Published: December 2022

Abstract
Background
Mature B-cell non-Hodgkin lymphomas are one of the most common hematological malignancies with a divergent clinical presentation, phenotype, and course of disease regulated by underlying genetic mechanism.

Main body
Genetic and molecular alterations are not only critical for lymphomagenesis but also largely responsible for differing therapeutic response in these neoplasms. In recent years, advanced molecular tools have provided a deeper understanding regarding these oncogenic drives for predicting progression as well as refractory behavior in these diseases. The prognostic models based on gene expression profiling have also been proved effective in various clinical scenarios. However, considerable overlap does exist between the genotypes of individual lymphomas and at the same time where additional molecular lesions may be associated with each entity apart from the key genetic event. Therefore, genomics is one of the cornerstones in the multimodality approach essential for classification and risk stratification of B-cell non-Hodgkin lymphomas.

Conclusion
We hereby in this review discuss the wide range of genetic aberrancies associated with tumorigenesis, immune escape, and chemoresistance in major B-cell non-Hodgkin lymphomas.
An assessment of ensemble learning approaches and single-based machine learning algorithms for the characterization of undersaturated oil viscosity
Authors: Akano Theddeus T. , James Chinemerem C. 
Published: December 2022

AbstractBackgroundPrediction of accurate crude oil viscosity when pressure volume temperature (PVT) experimental results are not readily available has been a major challenge to the petroleum industry. This is due to the substantial impact an inaccurate prediction will have on production planning, reservoir management, enhanced oil recovery processes and choice of design facilities such as tubing, pipeline and pump sizes. In a bid to attain improved accuracy in predictions, recent research has focused on applying various machine learning algorithms and intelligent mechanisms. In this work, an extensive comparative analysis between single-based machine learning techniques such as artificial neural network, support vector machine, decision tree and linear regression, and ensemble learning techniques such as bagging, boosting and voting was performed. The prediction performance of the models was assessed by using five evaluation measures, namely mean absolute error, relative squared error, mean squared error, root mean squared error and root mean squared log error.ResultsThe ensemble methods offered generally higher prediction accuracies than single-based machine learning techniques. In addition, weak single-based learners of the dataset used in this study (for example, SVM) were transformed into strong ensemble learners with better prediction performance when used as based learners in the ensemble method, while other strong single-based learners were discovered to have had significantly improved prediction performance.ConclusionThe ensemble methods have great prospects of enhancing the overall predictive accuracy of single-based learners in the domain of reservoir fluid PVT properties (such as undersaturated oil viscosity) prediction.
Novel variants associated with adiponectin-related traits in Awassi ewes
Authors: AL-Jaryan Israa L. , AL-Thuwaini Tahreer M. , Al-Jebory Hashim H. 
Published: December 2022

Abstract
Background
Adipose tissue secretes adiponectin (ADIPOQ), a hormone related to fat oxidation, glucose metabolism, and reproduction. The polymorphism of adiponectin is associated with productive traits in domestic animals. Thus, this study investigated the association of adiponectin gene polymorphism with lipid profile and reproductive hormones in Awassi ewe. In this study, 200 ewes between the ages of 2.5 and 5 years, neither pregnant nor lactating, were included. To determine the lipid profile and reproductive hormones, sera were separated from the blood. DNA extraction, genotyping, and sequencing reactions were used to verify the variants in the amplified fragments (exon 1).

Results
Three genotypes, CC, CA, and AA, were identified from 368 bp amplicons (exon 1). A sequencing reaction revealed a novel mutation, c.198473337C > A, in the CA genotype. The results revealed significant differences (P ≤ 0.05) in cholesterol and HDL levels in the AA genotype than CC and CA genotypes. The AA genotype had higher estradiol and progesterone levels (50.52 ± 0.64) (pg/ml) and (7.10 ± 0.04) (ng/ml), respectively, than those with the CC and CA genotypes.

Conclusions
These results conclude that the ADIPOQ gene affects lipid profiles and sex hormone levels in Awassi sheep. Choosing sheep that are polymorphic for the ADIPOQ gene should be a future study, as this gene could be linked to high prolificacy.
The efficacy and safety of dexmedetomidine in preventing emergence delirium in paediatric patients following ophthalmic surgery: a systematic review and meta-analysis of randomised controlled trials
Authors: Alassaf Hind M. , Sobahi Amal M. , Alshahrani Nasser S. 
Published: December 2022

Abstract
Background
The leading cause of emergence delirium (ED) in children postoperatively is the exposure to inhalational anaesthetics. ED can occur immediately after waking from anaesthesia, making patients generally uncooperative and agitated. Dexmedetomidine has sedative and analgesic effects and helps to reduce agitation and delirium and improve hemodynamic stability and the recovery of respiratory function; in addition to decreasing pain intensity, it is also well known for helping reduce nausea and vomiting.

Objectives
This updated systematic review meta-analysis investigate and summarise currently available evidence on the use of dexmedetomidine to prevent ED, reduce postoperative nausea and vomiting (PONV) and decrease the need for rescue analgesia in paediatric patients undergoing ophthalmic surgery.

Methods
The medical databases EMBASE, PubMed and Cochrane Library were searched for randomised controlled trials published between January 2020 and August 2022 that used Dexmedetomidine in paediatric patients undergoing ophthalmic surgery. The protocol was prospectively registered with PROSPERO (CRD42022343622). The review was accomplished according to the ‘Preferred Reporting Items for Systematic Reviews and Meta-Analyses’, and the meta-analysis was conducted by using RevMan5.4. These studies examine the efficacy of dexmedetomidine in preventing ED in children undergo ophthalmic surgery. The Cochrane ROB-1 was used to assess risk of bias (ROB).

Results
Eight studies comprised of 629 participants, of which 315 received dexmedetomidine and 314 placebos were examined. PAED score identified ED following surgery. A review and meta-analysis indicated that dexmedetomidine reduces ED incidence (RR = 0.39; 95% CI 0.25–0.62). Similarly, it reduces the use of rescue analgesia (RR = 0.38; 95% CI 0.25–0.57). However, dexmedetomidine did not help prevent PONV since no difference was found between groups (RR = 0.33; 95% CI 0.21–0.54).

Conclusion
This review showed that dexmedetomidine helped to reduce ED incidence in paediatric patients after ophthalmic surgery and reduced the need for rescue analgesia compared to placebo or other medications.