bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between taking a death certificate course and practical knowledge about death certificate among Saudi medical students
Authors: Aljerian Khaldoon , AlHogail Norah , Alaqeel Saud , Alderaan Khayyal , Al-hawamdeh Abdulla , Alhudhaif Hani 
Published: December 2022

In Saudi Arabia, family members, general practitioners, morticians, or police officer, who are eligible to request autopsies, refrain from doing so to expedite the burial of the deceased. Inaccurate entries into the medical death certificate facilitate so. The reason for ignoring the completion of death certificates is not fully explored. Yet, incompetence or avoiding medicolegal allegations seem to be causative factors. In this study, we conducted a cross-sectional study on 335 medical students from all years of medical school to determine the association between taking the death certificate course and the level of knowledge about death certificates among medical students. The results showed an increase in the level of knowledge of students who took the course compared to the students who did not. Among the students who have seen death certificates, the majority have not seen enough number of death certificates. Cultural mores of the medical students are expected to govern their carefulness in filling out the death certificates.
The Big Five personality traits and theory of planned behavior in physical education students
Authors: Li Yun , Ruzicka Michal 
Published: December 2022

Purpose: This study aimed to test the correlation between the Big Five personality traits and the theory of planned behavior in Chinese physical education students.
Design/methodology/approach: This is a cross sectional study which used the Big Five Inventory-44 and the Physical Educator’s Intention Toward Teaching Individuals with Disabilities III. Using a large number of randomly selected samples, a total of N =2305 physical education students (782 females and 1523 males, M age = 20.12, SD = 1.47) were purposely selected from 10 normal or comprehensive universities located in Eastern, Central and Western China.
Findings: Our findings showed that the big five personality traits and theory of planned behavior are closely linked in physical education students. Future intervention experiments can focus on the impact of the big five personality traits on the TPB, to improve the mental health and academic performance of physical education students.
Research and practical limitations/implications: First, the research method of this study is single, and subsequent studies can add mediator or moderator variables. Second, because this study is a cross-sectional study, it fails to explore the causal relationship between the Big Five personality traits and the various dimensions of the planned behavior theory of physical education for normal students.
Originality/value: This study explored the relationship of the Big Five personality traits with intention, attitude toward the behavior, and subjective norms of physical education students, within the theory of planned behavior. It suggests ways for educators, counselors, and coaches to promote the physical and mental development of physical education students.
Order Fulfillment Under Pick Failure in Omnichannel Ship-From-Store Programs
Authors: Das Sagnik , Ravi R. , Sridhar Srinath 
Published: December 2022

Problem definition: We consider the setting where a retailer with many physical stores and an online presence seeks to fulfill online orders using an omnichannel fulfillment program, such as buy-online ship-from-store. These fulfillment strategies try to minimize cost while fulfilling orders within acceptable service times. We focus on single-item orders. Typically, all online orders for the item are sent to a favorable set of locations to be filled. Failed trials are sent back for further stages of trial fulfillment until the process times out. The multistage order fulfillment problem is thus an interplay of the pick-failure probabilities at the stores where they may be shipped from and the picking, shipping, and cancellation costs from these locations. Methodology: We model the problem as one of sequencing the stores from which an order is attempted to be picked and shipped in the most cost-effective way over multiple stages. We solve the fulfillment problem optimally by taking into account the changing pick-failure probabilities as a result of other online order fulfillment trials by casting it as a network flow problem with convex costs. We incorporate this as the second stage of a two-stage online order acceptance problem and generalize earlier results to the case with pick failures at stores. Results: We investigate the real-world performance of our methods and models on real order data of several of the top U.S. retailers that use our collaborating e-commerce solutions provider to optimize their fulfillment strategies. Academic/Practical Relevance: Our work enables retailers to incorporate pick failure in their order management systems for ship-from-store programs. Our new online order-acceptance policies that take into account pick failures can thus create significant savings for omnichannel retailers. Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2022.1164 .
A quality improvement study on the relationship between intranasal povidone-iodine and anesthesia and the nasal microbiota of surgery patients
Authors: Hammond Eric N. , Kates Ashley E. , Putman-Buehler Nathan , Watson Lauren , Godfrey Jared J. , Brys Nicole , Deblois Courtney , Steinberger Andrew J. , Cox Madison S. , Skarlupka Joseph H. , Haleem Ambar , Bentz Michael L. , Suen Garret , Safdar Nasia 
Published: December 2022

Introduction
The composition of the nasal microbiota in surgical patients in the context of general anesthesia and nasal povidone-iodine decolonization is unknown. The purpose of this quality improvement study was to determine: (i) if general anesthesia is associated with changes in the nasal microbiota of surgery patients and (ii) if preoperative intranasal povidone-iodine decolonization is associated with changes in the nasal microbiota of surgery patients.

Materials and methods
One hundred and fifty-one ambulatory patients presenting for surgery were enrolled in a quality improvement study by convenience sampling. Pre- and post-surgery nasal samples were collected from patients in the no intranasal decolonization group (control group, n = 54). Pre-decolonization nasal samples were collected from the preoperative intranasal povidone-iodine decolonization group (povidone-iodine group, n = 97). Intranasal povidone-iodine was administered immediately prior to surgery and continued for 20 minutes before patients proceeded for surgery. Post-nasal samples were then collected. General anesthesia was administered to both groups. DNA from the samples was extracted for 16S rRNA sequencing on an Illumina MiSeq.

Results
In the control group, there was no evidence of change in bacterial diversity between pre- and post-surgery samples. In the povidone-iodine group, nasal bacterial diversity was greater in post-surgery, relative to pre-surgery (Shannon’s Diversity Index (P = 0.038), Chao’s richness estimate (P = 0.02) and Inverse Simpson index (P = 0.027). Among all the genera, only the relative abundance of the genus Staphylococcus trended towards a decrease in patients after application (FDR adjusted P = 0.06). Abundant genera common to both povidone-iodine and control groups included Staphylococcus, Bradyrhizobium, Corynebacterium, Dolosigranulum, Lactobacillus, and Moraxella.

Conclusions
We found general anesthesia was not associated with changes in the nasal microbiota. Povidone-iodine treatment was associated with nasal microbial diversity and decreased abundance of Staphylococcus. Future studies should examine the nasal microbiota structure and function longitudinally in surgical patients receiving intranasal povidone-iodine.
”Som om det aldri har skjedd”
Authors: Ottesen Siri Hovda , Tysvær Aasfrid 
Published: December 2022

“As if it never happened”: Fictional Work with Forgiveness as a Value amongst 5th–7th Graders
This article examines how middle school pupils respond to an aesthetic approach to forgiveness as a value. We observed a group of pupils aged 10–12 while they were investigating and discussing Stian Hole’s picturebook Garmanns gate (Garmann’s Street, 2008) together with their teacher. We claim that Garmanns gate can be read as a story about forgiveness, and that it is also a picturebook that invites the reader to take a performative, aesthetic position; the reader is encouraged to pay attention to how the story is told as well as to the story itself (Ørjasæter, “Terskelposisjonen”). The focus of the article is to what extent investigating Garmanns gate will shed light on forgiveness, a value which is central in the Norwegian school’s purpose clause. We analysed their comments in the light of a definition that identifies different aspects of the concept of forgiveness. Our theoretical framework is Martha Nussbaum’s theory on the importance of narrative imagination in taking other peoples’ perspectives, and Louise Rosenblatt’s theory on aesthetic and efferent reading. We also refer to Maria Nikolajeva’s views on how the picturebook can promote emotional literacy. To deal with the concept of forgiveness, we use Paul Leer-Salvesen’s definition, which enables us to look at different aspects of the concept. These aspects together with “the emancipating consequences of forgiveness” are the categories we use in analysing our findings (Leer-Salvesen, Min skyld 96). We find that an aesthetic approach to Garmanns gate may provide an opportunity for a broader understanding of forgiveness, and we find that the teacher’s role is essential in guiding the pupils in the common aesthetic approach to the book, and in bringing forth reflections in the conversations.
Small-molecule metabolites in SARS-CoV-2 treatment: a comprehensive review
Authors: Alipoor Reza , Ranjbar Reza 
Published: December 2022

Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread all over the world. In this respect, traditional medicinal chemistry, repurposing, and computational approaches have been exploited to develop novel medicines for treating this condition. The effectiveness of chemicals and testing methods in the identification of new promising therapies, and the extent of preparedness for future pandemics, have been further highly advantaged by recent breakthroughs in introducing noble small compounds for clinical testing purposes. Currently, numerous studies are developing small-molecule (SM) therapeutic products for inhibiting SARS-CoV-2 infection and replication, as well as managing the disease-related outcomes. Transmembrane serine protease (TMPRSS2)-inhibiting medicinal products can thus prevent the entry of the SARS-CoV-2 into the cells, and constrain its spreading along with the morbidity and mortality due to the coronavirus disease 2019 (COVID-19), particularly when co-administered with inhibitors such as chloroquine (CQ) and dihydroorotate dehydrogenase (DHODH). The present review demonstrates that the clinical-stage therapeutic agents, targeting additional viral proteins, might improve the effectiveness of COVID-19 treatment if applied as an adjuvant therapy side-by-side with RNA-dependent RNA polymerase (RdRp) inhibitors.
Freikirchen in Hand- und Lehrbüchern der Konfessionskunde
Authors: Triebel Lothar 
Published: December 2022

Zusammenfassung
Hand- und Lehrbücher der Konfessionskunde gelten im allgemeinen als probates Mittel, um sich einen Überblick über andere Kirchen zu verschaffen. In diesem Beitrag wird an den Beispielen „Pfingstbewegungen“ und „Altlutheraner“ untersucht, was ausgewählte neuere Exemplare dieser Literaturgattung in Bezug auf Freikirchen leisten. Zuvor wird grundsätzlich erörtert, wie konfessionskundliche Darstellungen methodisch sachgemäß sein können.
lncRNA ZFAS1 promotes intervertebral disc degeneration by upregulating AAK1
Authors: Wang Zheng , Liu Bin , Ma Xiangyu , Wang Yu , Han Wenfeng , Xiang Liangbi 
Published: December 2022

Abstract
We investigated the function of lncRNA zinc finger antisense 1 (ZFAS1) in intervertebral disc degeneration (IDD) progression in vitro and in vivo. Nucleus pulposus (NP) tissues were obtained from 20 patients with IDD. IL-1β was used to stimulate primary NP cells to establish the IDD models in vitro. Gene expression was determined by RT-qPCR. 5-Ethynyl-2′-deoxyuridine and flow cytometry were performed to determine cell proliferation and apoptosis, and western blotting was conducted to measure the apoptosis- and extracellular matrix (ECM)-related protein expression. Luciferase reporter assay was used to examine the interactions between the genes. We also investigated the effect of ZFAS1 in a mouse model of IDD induced by needle punctures. Our results showed that ZFAS1 expression was elevated in degenerative NP tissues and IL-1β-treated NP cells. ZFAS1 knockdown inhibited NP cell apoptosis and ECM degradation induced by IL-1β. Mechanically, ZFAS1 sponged miR-4711-5p and adaptor-associated kinase 1 (AAK1) was targeted by miR-4711-5p. Furthermore, AAK1 overexpression partially eliminated the impact of ZFAS1 depletion on NP cell proliferation, apoptosis, and ECM degradation. More importantly, the results of the in vivo studies confirmed the effect of silencing ZFAS1 on alleviating the symptoms of IDD mice. Overall, silencing ZFAS1 inhibits IDD progression by reducing NP cell apoptosis and ECM degradation through the miR-4711-5p/AAK1 axis.
lncRNA ELFN1-AS1 enhances the progression of colon cancer by targeting miR-4270 to upregulate AURKB
Authors: Peng Shuangqin , Luo Yanjun , Chen Lijuan , Dai Kang , Wang Qin 
Published: December 2022

Abstract
The oncogenic role of lncRNA ELFN1-AS1 has been described in different cancers, including colon cancer (CC). However, how ELFN1-AS1 regulates CC malignancy remains unclear. In this study, ELFN1-AS1, AURKB, and miR-4270 expression levels in CC cells and tissues were determined using RT-qPCR and western blotting. CCK-8 and wound healing assays were also performed to analyze alterations in CC cell proliferation and migration. The expression of apoptosis-related proteins (Bax and Bcl-2) was determined via western blot analysis. RNA immunoprecipitation (RIP) assays coupled with luciferase reporter assays were employed to verify the relationship between miR-4270, ELFN1-AS1, and AURKB. An in vivo assay was performed using xenograft tumors in mice to detect the change of tumor growth. It was found that AURKB and ELFN1-AS1 expression was upregulated, whereas miR-4270 was downregulated in CC cells and tissues. ELFN1-AS1 silencing exhibited anti-proliferative, anti-migratory, and pro-apoptotic effects in CC cells. The tumor-suppressive effect of ELFN1-AS1 silencing was verified using in vivo assays. MiR-4270 was predicted to be a target of ELFN1-AS1 and AURKB as a target of miR-4270. Their interactions were further elucidated using luciferase reporter and RNA RIP assays. More importantly, treatment with a miR-4270 inhibitor not only rescued the tumor-suppressing effect of ELFN1-AS1 silencing but also abrogated the tumor suppressor functions of AURKB silencing in CC cells. Taken together, the ELFN1-AS1/miR-4270/AURKB axis facilitates CC tumorigenesis; therefore, targeting this axis might be a promising intervention in preventing CC progression.
Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer
Authors: Hu Fangfang , Zhao Liangtao , Wang Yang , Ye Hao , Tang Haodong , Zhou Jiahua 
Published: December 2022

Abstract
Integrin subunit alpha 3 (ITGA3) expression correlates with the development and prognosis of human cancers. This study aimed to investigate the association of ITGA3 expression with pancreatic cancer (PCa) prognosis. The ITGA3 gene expression data were extracted from The Cancer Genome Atlas (TCGA) pancreatic adenocarcinoma (PAAD) cohort and 14 Gene Expression Omnibus microarray datasets. The differences in ITGA3 expression levels between tumor and non-tumor tissues were compared using the Mann–Whitney U test. Cox regression analysis and meta-analysis were performed to detect the association of ITGA3 expression with PCa prognosis. ITGA3 expression was higher in tumors than in controls. Tumors with advanced grades (3/4) had higher ITGA3 levels compared with early-grade tumors (1/2). The meta-analysis of the TCGA PAAD cohort and seven microarray datasets (GSE28735, GSE62452, GSE79668, GSE71729, GSE57495, GSE78229, and GSE21501) showed that ITGA3 was a prognostic biomarker in PCa (hazard ratio (HR) = 1.38, 95% confidence interval (CI) 1.26–1.51, p < 0.00001). Five ITGA3-related genes, including ITGB1 (HR = 1.6), ITGB5 (HR = 1.6), ITGB6 (HR = 1.6), LAMA3 (HR = 2.1), and CD9 (HR = 2.3), correlated with PCa prognosis significantly (p < 0.05). Functional enrichment analysis showed that ITGA3 was related to “hsa04151: PI3K-Akt signaling pathway” and “hsa04510: Focal adhesion.” We concluded that high ITGA3 expression was a potential prognostic biomarker in PCa.
Comparative simulations study of radiations shielding properties of 69P2O5–10Gd2O3/10GdF3–10BaO–10ZnO–1Er2O3 glasses
Authors: Sanaullah  , Dinar Falak , Khadija  , Khattak Shaukat Ali , Shoib Muhammad , Ullah Irfan , Rooh Gul , Wabaidur Saikh Mohammad , Islam Muhammad Ataul , Zulfiqar Syed , Khan Gulzar , Khan Tahirzeb 
Published: December 2022

Abstract
We study the theoretical and simulated shielding properties of 69P2O5–10Gd2O3–10BaO–10ZnO–1Er2O3 and 69P2O5–10GdF3–10BaO–10ZnO-1Er2O3 glasses. We exploit advanced simulation (MCNPX) and Phy-X, an online Photon Shielding and Dosimetry software, in the 0.001–15 MeV energy range, to calculate the linear attenuation coefficient and mass attenuation coefficients of the samples. The obtained mass attenuation coefficient is then used to calculate the critical radiation shielding characteristics, such as the half-value layer, mean free path, tenth value layer, and effective atomic number. The calculated LAC values range from 108.759 to 0.097 and from 84.124 to 0.087 cm−1 while HVL values range from 0.006 to 7.164 and from 0.008 to 8.013 cm, and MFP values vary from 0.009 to 10.335 and from 0.012 to 11.561 cm for ZBaOEr and ZBaFEr, respectively, with energy ranging from 0.015 to 15 MeV. We find that the results obtained from MCNPX and Phy-X are consistent with each other, based on the computed relative difference. The glass sample containing Gd2O3 exhibits better shielding properties than the one with GdF3, over the entire energy range. Our examined glass samples are thick enough to substantially lessen the intensity of incident X-rays and gamma rays.
Aspetti testuali e problemi linguistici (di datazione e localizzazione) dell’antica lingua del cibo
Authors: Pregnolato Simone 
Published: December 2022

Abstract
The paper focuses on some methodological, philological and linguistic problems related to the study of the most ancient culinary texts (cookbooks and practical documents) in Italian vernacular (14th century). The most relevant problems relate to the precise dating and localization of the manuscripts. These preliminary aspects are essential in order to achieve the Atlante della lingua e dei testi della cultura gastronomica italiana dall’età medievale all’Unità which can assist in identifying the origins and history of culinary language in the history of Italian.
La cucina delle parole
Authors: Alba Monica 
Published: December 2022

Abstract
The Glossario Artusiano (Artusian Glossary) has been designed as a lexicographical tool, capable of gathering and studying the whole lexicographical wealth of Pellegrino Artusi’s La Scienza in cucina e l’Arte di mangiar bene (1st edition in 1891; 15th edition in 1911), a cornerstone of Italian gastronomic culture. By looking at some case studies, this article illustrates the criteria, tools and methodology which may have been used to compose the glossary. The purpose is to highlight how these results can establish a constructive dialogue with the Vocabolario Storico della Lingua Italiana della Gastronomia (VoSLIG), within the framework of the AtLiTeG Project.
De la V1 à la V2 de la Cité des dames de Christine de Pizan : étude de quelques révisions linguistiques
Authors: Valentini Andrea 
Published: December 2022

Abstract
This paper analyses two processes at work in Christine de Pizan’s reworking of the first version (V1) of her Book of the City of Ladies to produce a second version (V2). These two processes consist in the elimination of repetitions and the addition of synonyms to create binomials. They show that the author paid great attention to the language of her text when reworking it. They also appear to be typical of the search for a higher style. The fact that Christine de Pizan uses a high style to refer to women is all the more interesting: according to the principle of matching style to content, a high style contributes to the importance of women and thus, ultimately, to the author’s feminist struggle.
Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates
Authors: Pettmann Johannes , Awada Lama , Różycki Bartosz , Huhn Anna , Faour Sara , Kutuzov Mikhail , Limozin Laurent , Weikl Thomas R , van der Merwe P Anton , Robert Philippe , Dushek Omer 
Published: December 2022

AbstractT cells use their T‐cell receptors (TCRs) to discriminate between lower‐affinity self and higher‐affinity foreign peptide major‐histocompatibility‐complexes (pMHCs) based on the TCR/pMHC off‐rate. It is now appreciated that T cells generate mechanical forces during this process but how force impacts the TCR/pMHC off‐rate remains debated. Here, we measured the effect of mechanical force on the off‐rate of multiple TCR/pMHC interactions. Unexpectedly, we found that lower‐affinity TCR/pMHCs with faster solution off‐rates were more resistant to mechanical force (weak slip or catch bonds) than higher‐affinity interactions (strong slip bonds). This was confirmed by molecular dynamics simulations. Consistent with these findings, we show that the best‐characterized catch bond, involving the OT‐I TCR, has a low affinity and an exceptionally fast solution off‐rate. Our findings imply that reducing forces on the TCR/pMHC interaction improves antigen discrimination, and we suggest a role for the adhesion receptors CD2 and LFA‐1 in force‐shielding the TCR/pMHC interaction.
Soviet Lithuanian New Year Greeting Card: Semiotics of Recto
Authors: Atminytė Evelina 
Published: December 2022

The article discusses the semiotics of greeting card with focus on the discursive configuration of the recto side. The aim is twofold: to examine the possible ways image and verbal text are combined and identify the meaning produced by its different configurations. Soviet Lithuanian New Year greeting cards (dated from the late 1950s to 1989) are analyzed to accomplish the study. The methodological approach is compound. The guidelines of Greimasian theory of semiotics and Tartu-Moscow semiotic school as well as the ideas of Jacques Fontanille and Jean-Marie Floch are used to perform the study.
The discourse analysis revealed that when placed on the recto side greeting text both anchors the content of the image and acts as a performative utterance. Depending on the specific configuration of the recto side and the material aspects of a greeting card, the role of enunciator can be subjected either to the artist or image figures. However, in some cases the performative function becomes secondary. For example, when playfulness established by the interrelation of image and verbal text is given priority over the greeting act.