bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal long-run money growth rate in a cash-in-advance economy with labor-market frictions
Authors: Chen Been-Lon , Liao Shian-Yu , Liu Dongpeng , Liu Xiangbo 
Published: September 2022

AbstractWe revisit the Friedman rule in a labor search model and extend Heer (2003), Cooley and Quadrini (2004), and Wang and Xie (2013) to one that allows for endogenous growth. We show that, even without a liquidity effect or a CIA constraint on firms’ wage payment, our model offers a different channel for moderate money growth to increase welfare. Intuitively, in a one-sector endogenous growth economy, the technology is of constant returns with respect to capital. When the labor market is frictional, a moderate increase in money growth induces an expansion in vacancy and employment. Labor and capital are complements in production. With an increase in employment, when the technology is neoclassical, the decreasing return in capital leads to a lower marginal product of labor. However, in an endogenous growth framework wherein the technology exhibits socially constant returns in capital, the marginal product of labor is constant. Due to a constant marginal product of labor, modest inflation raises employment, enlarges economic growth, and increases welfare. Moreover, the optimal long-run inflation rate departs from the Friedman rule, even when the Hosios rule holds. Finally, we find that our model with sustainable growth fits the data better than that without sustainable growth.
Survey of pesticide application practices and technologies in Georgia agronomic crops
Authors: Virk Simerjeet S. , Prostko Eric P. 
Published: September 2022

AbstractPesticide regulations and application technologies are changing rapidly due to rising concerns around off-target movement of pesticides and increased focus on improving the efficiency of pesticide applications. In order to conduct relevant applied research and develop educational programs related to pesticide application, it is necessary to understand the common application practices and technologies that growers use. A survey was conducted to assess common pesticide application practices and technologies used by Georgia growers. Both online and printed survey copies were distributed by county agricultural extension agents to growers in all 159 counties. A total of 186 responses representing agronomic crops in 65 counties were received and analyzed for results. Main results of this survey indicated that 1) 72% of respondents produced ≥200 ha of crops; 2) 29% of respondents received their information from university Extension personnel; 3) 42% of respondents used a separate sprayer for applications of dicamba, 2,4-D, or 2,4-DB; 4) 46% of respondents used sprayers with boom lengths ≥18.3 m; 5) 65% of respondents used ≥121 L/ha to apply pesticides; 6) 53% of respondents used three or more different nozzles on their spray booms throughout the season; 7) 68% of respondents used TeeJet® nozzles; 8) 65% of respondents used global positioning systems and rate controllers on their application equipment; 9) 66% of respondents recorded their pesticide application data on a notepad or diary; and 10) 39% of respondents reported that application accuracy is the biggest advantage of new spray technologies. Respondents also reported that weather, timing, and pesticide drift/regulations were their biggest application challenges and that more research is needed on topics such as rates, carrier volumes, pest control, chemicals and adjuvants. Information from this survey provides useful insights into the current application practices, technologies, and research needs of Georgia growers and will be used for developing appropriate research and educational efforts.
Diverse Magmatic Evolutionary Trends of the Northern Andes Unraveled by Paleocene to Early Eocene Detrital Zircon Geochemistry
Authors: Jaramillo Juan S. , Zapata Sebastian , Carvalho Monica , Cardona Agustin , Jaramillo Carlos , Crowley James L. , Bayona Germán , Caballero‐Rodriguez Dayenari 
Published: September 2022

AbstractThe Paleocene‐early Eocene continental magmatic arc (PECMA) in the Northern Andes is an example of arc magmatism following a major collisional event. This arc formed after the arc‐continent collision between the Caribbean Plate and the South American continental margin at ca. 72 Ma. We used detrital zircon LA‐ICP‐MS and CA‐ID‐TIMS geochronology and geochemistry to complement the limited plutonic record of the PECMA and better characterize the PECMA's magmatic evolution. Zircon geochronology and their respective trace element geochemistry were analyzed from Paleocene‐early Eocene strata of the Bogotá Formation in the foreland region. Our results show that after the collision of the Caribbean Plate, the magmas in the PECMA differentiated under a thick continental crust with limited subduction input at ca. 66 Ma. By 62–50 Ma, scattered patterns of Hf, U, U/Yb, and Yb/Gd ratios in detrital zircons suggest the existence of contrasting magmatic inputs attributed to different depths of crustal fractionation, varied temperatures of crystallization, and significant mantle and subduction inputs. These diverse magmatic patterns reflect the evolution of the continental crust. We proposed that oblique convergence and strike‐slip tectonics favored contrasting crustal architectures along the continental margin while local lithosphere dripping from a previously thickened crust promoted the formation of hot magmas under a thick continental crust.
Changes in Plate Motions Caused by Increases in Gravitational Potential Energy of Mountain Belts
Authors: England Philip , Molnar Peter 
Published: September 2022

AbstractReconstructions of motions of the Nazca, South American, and Indian plates record short‐duration (≲10 Myr) variations in angular velocity, which enable a vector‐based test of the hypothesis that mountain uplift can cause changes in plate motion. Reductions in velocity of Nazca and South America between ∼12 and 6 Ma coincide with a phase of rapid surface uplift in the Central Andes. Decrease in the rate of India's convergence with Eurasia between ∼20 and 10 Ma corresponds to an increase in gravitational potential energy per unit area (GPE) within Tibet, marked by a transition from crustal thickening to thinning. The vectorial test shows that, in each case, the only change in driving force capable of balancing the change in basal drag is an increased resistance along the convergent boundary to the plate. Changes in GPE associated with mountain uplift provide a calibration for basal drags on plates. Basal tractions of ∼0.1–1 MPa provide resisting forces comparable in magnitude to driving forces from GPE variation in ocean lithosphere. The rapid change in motion of the Indian plate between about 48 and 41 Ma is explained by the juxtaposition of the Indian continent against the Andean‐type margin of the Transhimalaya and reduction in driving force due to loss of the slab. The net slab driving force lost was ∼2–4 TN m−1, in agreement with previous studies suggesting that forces resisting slabs' penetration into the mantle largely offset their negative buoyancy.
Non‐Local Eddy‐Mean Kinetic Energy Transfers in Submesoscale‐Permitting Ensemble Simulations
Authors: Jamet Quentin , Leroux Stephanie , Dewar William K. , Penduff Thierry , Le Sommer Julien , Molines Jean‐Marc , Gula Jonathan 
Published: September 2022

AbstractUnderstanding processes associated with eddy‐mean flow interactions helps our interpretation of ocean energetics, and guides the development of parameterizations. Here, we focus on the non‐local nature of Kinetic Energy (KE) transfers between mean and turbulent reservoirs. Transfers are interpreted as non‐local when the energy extracted from the mean flow does not locally sustain an growth of energy in the turbulent flow, or vice versa. The novelty of our approach is to use ensemble statistics to define the mean and the turbulent flow. Based on KE budget considerations, we first rationalize the eddy‐mean separation in the ensemble framework, and discuss the interpretation of a mean flow driven by the prescribed (surface and boundary) forcing and a turbulent flow u′ driven by non‐linear dynamics sensitive to initial conditions. We then analyze 120‐day long, 20‐member ensemble simulations of the Western Mediterranean basin run at resolution. Our main contribution is to recognize the prominent contribution of the cross energy term to explain non‐local energy transfers, which provides a strong constraint on the horizontal organization of eddy‐mean flow KE transfers since the cross energy term vanishes identically for perturbations orthogonal to the mean flow . We also highlight the prominent contribution of vertical turbulent fluxes for energy transfers within the surface mixed layer. Analyzing the scale dependence of non‐local energy transfers supports the local approximation usually made in the development of meso‐scale, energy‐aware parameterizations for non‐eddying models, but points out to the necessity of accounting for non‐local dynamics in the meso‐to‐submeso scale range.
Non-invasive continuous cardiac output monitoring in infants with hypoxic ischaemic encephalopathy
Authors: Garvey Aisling A. , O’Neill Roisin , Livingstone Vicki , Pavel Andreea M. , Finn Daragh , Boylan Geraldine B. , Murray Deirdre M. , Dempsey Eugene M. 
Published: September 2022

Abstract
Objective
To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE).

Study design
Prospective observational study of 44 infants with HIE (23 mild, 17 moderate, 4 severe) and 17 term controls. Infants with HIE had non-invasive CO monitoring (NICOM) continuously in the neonatal unit. Term controls had NICOM recorded at 6 and 24 h. A mixed-modelling approach was used to assess change in CO over time by group.

Results
Infants with moderate HIE have significantly lower CO than the mild group at all timepoints (10.7 mls/kg/min lower, 95% CI:1.0,20.4, p = 0.03) which increases over time, driven by a gradual increase in stroke volume (SV). CO increased further during rewarming predominantly due to an increase in HR.

Conclusion
TH has a significant impact on HR but SV appears largely unaffected. NICOM may provide a non-invasive, continuous, low-cost alternative to monitoring CO in infants with HIE however further research is warranted.
Protein tyrosine kinase 2b inhibition reverts niche-associated resistance to tyrosine kinase inhibitors in AML
Authors: Allert Catana , Waclawiczek Alexander , Zimmermann Sarah Miriam Naomi , Göllner Stefanie , Heid Daniel , Janssen Maike , Renders Simon , Rohde Christian , Bauer Marcus , Bruckmann Margarita , Zinz Rafael , Pauli Cornelius , Besenbeck Birgit , Wickenhauser Claudia , Trumpp Andreas , Krijgsveld Jeroen , Müller-Tidow Carsten , Blank Maximilian Felix 
Published: September 2022

AbstractFLT3 tyrosine kinase inhibitor (TKI) therapy evolved into a standard therapy in FLT3-mutated AML. TKI resistance, however, develops frequently with poor outcomes. We analyzed acquired TKI resistance in AML cell lines by multilayered proteome analyses. Leupaxin (LPXN), a regulator of cell migration and adhesion, was induced during early resistance development, alongside the tyrosine kinase PTK2B which phosphorylated LPXN. Resistant cells differed in cell adhesion and migration, indicating altered niche interactions. PTK2B and LPXN were highly expressed in leukemic stem cells in FLT3-ITD patients. PTK2B/FAK inhibition abrogated resistance-associated phenotypes, such as enhanced cell migration. Altered pathways in resistant cells, assessed by nascent proteomics, were largely reverted upon PTK2B/FAK inhibition. PTK2B/FAK inhibitors PF-431396 and defactinib synergized with different TKIs or daunorubicin in FLT3-mutated AML. Midostaurin-resistant and AML cells co-cultured with mesenchymal stroma cells responded particularly well to PTK2B/FAK inhibitor addition. Xenograft mouse models showed significant longer time to leukemia symptom-related endpoint upon gilteritinib/defactinib combination treatment in comparison to treatment with either drug alone. Our data suggest that the leupaxin-PTK2B axis plays an important role in acquired TKI resistance in AML. PTK2B/FAK inhibitors act synergistically with currently used therapeutics and may overcome emerging TKI resistance in FLT3-mutated AML at an early timepoint.
Shipborne oceanic high-spectral-resolution lidar for accurate estimation of seawater depth-resolved optical properties
Authors: Zhou Yudi , Chen Yang , Zhao Hongkai , Jamet Cédric , Dionisi Davide , Chami Malik , Di Girolamo Paolo , Churnside James H. , Malinka Aleksey , Zhao Huade , Qiu Dajun , Cui Tingwei , Liu Qun , Chen Yatong , Phongphattarawat Sornsiri , Wang Nanchao , Chen Sijie , Chen Peng , Yao Ziwei , Le Chengfeng , Tao Yuting , Xu Peituo , Wang Xiaobin , Wang Binyu , Chen Feitong , Ye Chuang , Zhang Kai , Liu Chong , Liu Dong 
Published: September 2022

AbstractLidar techniques present a distinctive ability to resolve vertical structure of optical properties within the upper water column at both day- and night-time. However, accuracy challenges remain for existing lidar instruments due to the ill-posed nature of elastic backscatter lidar retrievals and multiple scattering. Here we demonstrate the high performance of, to the best of our knowledge, the first shipborne oceanic high-spectral-resolution lidar (HSRL) and illustrate a multiple scattering correction algorithm to rigorously address the above challenges in estimating the depth-resolved diffuse attenuation coefficientKdand the particulate backscattering coefficientbbpat 532 nm. HSRL data were collected during day- and night-time within the coastal areas of East China Sea and South China Sea, which are connected by the Taiwan Strait. Results include vertical profiles from open ocean waters to moderate turbid waters and first lidar continuous observation of diel vertical distribution of thin layers at a fixed station. The root-mean-square relative differences between the HSRL and coincident in situ measurements are 5.6% and 9.1% forKdandbbp, respectively, corresponding to an improvement of 2.7–13.5 and 4.9–44.1 times, respectively, with respect to elastic backscatter lidar methods. Shipborne oceanic HSRLs with high performance are expected to be of paramount importance for the construction of 3D map of ocean ecosystem.
Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser
Authors: Li Linze , Jiang Changqing , Duan Wanru , Wang Zhiyan , Zhang Feng , He Changgeng , Long Tiangang , Li Luming 
Published: September 2022

AbstractNeural electrode interfaces are essential to the stimulation safety and recording quality of various bioelectronic therapies. The recently proposed hierarchical platinum-iridium (Pt-Ir) electrodes produced by femtosecond lasers have exhibited superior electrochemical performance in vitro, but their in vivo performance is still unclear. In this study, we explored the electrochemical performance, biological response, and tissue adhesion of hierarchical Pt-Ir electrodes by implantation in adult rat brains for 1, 8, and 16 weeks. Regular smooth Pt-Ir electrodes were used as a control. The results showed that the electrochemical performance of both electrodes decreased and leveled off during implantation. However, after 16 weeks, the charge storage capacity of hierarchical electrodes stabilized at ~16.8 mC/cm2, which was 15 times that of the smooth control electrodes (1.1 mC/cm2). Moreover, the highly structured electrodes had lower impedance amplitude and cutoff frequency values. The similar histological response to smooth electrodes indicated good biocompatibility of the hierarchically structured Pt-Ir electrodes. Given their superior in vivo performance, the femtosecond laser-treated Pt-Ir electrode showed great potential for neuromodulation applications.
The role of ferroptosis in prostate cancer: a novel therapeutic strategy
Authors: Wang Yue , Ma Yifan , Jiang Kui 
Published: September 2022

AbstractThe incidence of prostate cancer is the second most among male cancers after lung cancer. Prostate cancer develops rapidly and is inclined to metastasize, and castration-resistant prostate cancer (CRPC) can be formed in the later stage, which brings great challenges to the prognosis and treatment. At present, the main treatment of prostate cancer is generally divided into four methods: surgery, chemotherapy, radiotherapy and endocrine therapy. However, the efficacy of these methods fails to satisfy the demands of patient prognosis. Ferroptosis is a newly discovered iron-dependent process, characterized by lipid peroxidation. Ferroptosis is associated with many diseases, especially tumor growth. In recent years, inhibiting tumor growth and overcoming tumor drug resistance by inducing ferroptosis has become a hot research topic. Previous studies have shown that induction of ferroptosis may be a new treatment for prostate cancer. We review the research progress of ferroptosis in prostate cancer in order to provide highly effective therapies for patients with prostate cancer.
Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia
Authors: da Silva Lais , Jiang Jinmai , Perkins Corey , Atanasova Kalina Rosenova , Bray Julie K. , Bulut Gamze , Azevedo-Pouly Ana , Campbell-Thompson Martha , Yang Xiaozhi , Hakimjavadi Hesamedin , Chamala Srikar , Ratnayake Ranjala , Gharaibeh Raad Z. , Li Chenglong , Luesch Hendrik , Schmittgen Thomas D. 
Published: September 2022

AbstractPancreatic acinar cells display a remarkable degree of plasticity and can dedifferentiate into ductal-like progenitor cells by a process known as acinar ductal metaplasia (ADM). ADM is believed to be one of the earliest precursor lesions toward the development of pancreatic ductal adenocarcinoma and maintaining the pancreatic acinar cell phenotype suppresses tumor formation. The effects of a novel pStat3 inhibitor (LLL12B) and the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) were investigated using 3-D cultures from p48Cre/+ and p48Cre/+LSL-KrasG12D/+ (KC) mice. LLL12B and TSA inhibited ADM in both KC and p48Cre/+ mouse pancreatic organoids. Furthermore, treatment with LLL12B or TSA on dedifferentiated acini from p48Cre/+ and KC mice that had undergone ADM produced morphologic and gene expression changes that suggest a reversal of ADM. Validation experiments using qRT-PCR (p48Cre/+ and KC) and RNA sequencing (KC) of the LLL12B and TSA treated cultures showed that the ADM reversal was more robust for the TSA treatments. Pathway analysis showed that TSA inhibited Spink1 and PI3K/AKT signaling during ADM reversal. The ability of TSA to reverse ADM was also observed in primary human acinar cultures. We report that pStat3 and HDAC inhibition can attenuate ADM in vitro and reverse ADM in the context of wild-type Kras. Our findings suggest that pharmacological inhibition or reversal of pancreatic ADM represents a potential therapeutic strategy for blocking aberrant ductal reprogramming of acinar cells.
Assessment of MRI to estimate metastatic dissemination risk and prometastatic effects of chemotherapy
Authors: Karagiannis George S. , Bianchi Anthony , Sanchez Luis Rivera , Ambadipudi Kamal , Cui Min-Hui , Anampa Jesus M. , Asiry Saeed , Wang Yarong , Harney Allison S. , Pastoriza Jessica M. , Lin Yu , Chen Xiaoming , Jones Joan G. , Entenberg David , Haddad Dana , Hodges Laura J. , Duong Timothy Q. , Sparano Joseph A. , Oktay Maja H. , Branch Craig A. , Condeelis John S. 
Published: September 2022

AbstractMetastatic dissemination in breast cancer is regulated by specialized intravasation sites called “tumor microenvironment of metastasis” (TMEM) doorways, composed of a tumor cell expressing the actin-regulatory protein Mena, a perivascular macrophage, and an endothelial cell, all in stable physical contact. High TMEM doorway number is associated with an increased risk of distant metastasis in human breast cancer and mouse models of breast carcinoma. Here, we developed a novel magnetic resonance imaging (MRI) methodology, calledTMEM Activity-MRI, to detect TMEM-associated vascular openings that serve as the portal of entry for cancer cell intravasation and metastatic dissemination. We demonstrate thatTMEM Activity-MRIcorrelates with primary tumor TMEM doorway counts in both breast cancer patients and mouse models, including MMTV-PyMT and patient-derived xenograft models. In addition,TMEM Activity-MRIis reduced in mouse models upon treatment with rebastinib, a specific and potent TMEM doorway inhibitor.TMEM Activity-MRIis an assay that specifically measures TMEM-associated vascular opening (TAVO) events in the tumor microenvironment, and as such, can be utilized in mechanistic studies investigating molecular pathways of cancer cell dissemination and metastasis. Finally, we demonstrate thatTMEM Activity-MRIincreases upon treatment with paclitaxel in mouse models, consistent with prior observations that chemotherapy enhances TMEM doorway assembly and activity in human breast cancer. Our findings suggest thatTMEM Activity-MRIis a promising precision medicine tool for localized breast cancer that could be used as a non-invasive test to determine metastatic risk and serve as an intermediate pharmacodynamic biomarker to monitor therapeutic response to agents that block TMEM doorway-mediated dissemination.
Improvement in symptom-related disruptions is associated with fewer days of short-acting beta-agonist use in asthma
Authors: Kaye Leanne , Vuong Vy , Barrett Meredith A. , Boers Elroy , Guilbert Theresa 
Published: September 2022

AbstractSignificant indirect healthcare costs are related to uncontrolled asthma, including productivity loss. Days with short-acting beta-agonist (SABA) use is associated with symptom-related disruptions at work, home, and school. Digital self-management platforms may support fewer days with SABA medication use and may reduce symptom-related disruptions.
Experimental investigation of wave-particle duality relations in asymmetric beam interference
Authors: Chen Dong-Xu , Zhang Yu , Zhao Jun-Long , Wu Qi-Cheng , Fang Yu-Liang , Yang Chui-Ping , Nori Franco 
Published: September 2022

AbstractWave-particle duality relations are fundamental for quantum physics. Previous experimental studies of duality relations mainly focus on the quadratic relation D2 + V2 ≤ 1, based on symmetric beam interference, while a linear form of the duality relation, predicated earlier theoretically, has never been experimentally tested. In addition, the difference between the quadratic form and the linear form has not been explored yet. In this work, with a designed asymmetric beam interference and by utilizing the polarization degree of freedom of the photon as a which-way detector, we experimentally confirm both forms of the duality relations. The results show that more path information is obtained in the quadratic case. Our findings reveal the difference between the two duality relations and have fundamental implications in better understanding these important duality relations.