bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aspirin may not be effective in prevention of deep vein thrombosis after meniscus root repair: a retrospective cohort study
Authors: Smith Scott , Pettit Robert , Flanigan David C. , Magnussen Robert A. 
Published: September 2022

Background:
Arthroscopic knee surgery has been associated with a low risk of symptomatic deep vein thrombosis (DVT), with previous studies demonstrating a risk of 0.12% to 3.7%. This risk of DVT and ideal prophylaxis in cases of meniscus root repair are unknown. The authors sought to determine the effectiveness of aspirin as DVT prophylaxis after meniscus root repair. The hypothesis was that there is no significant difference in the risk of symptomatic DVT after meniscus root repair with aspirin prophylaxis as compared with low molecular weight heparin (LMWH) or apixiban.

Methods:
Patients treated with repair of medial or lateral meniscus root tears over a 3 yr period were identified retrospectively. The risk of subsequent development of a symptomatic DVT was compared based on whether postoperative DVT prophylaxis was undertaken with aspirin or a stronger anticoagulant such as LMWH or apixiban.

Results:
Fifty-eight patients who underwent root repair (19 lateral and 39 medial) were identified. No symptomatic DVTs were identified in 42 patients (0%) who received LMWH or apixiban, but DVTs were identified in 3 of 16 patients (19%) who received aspirin (P=0.018). No significant differences in patient gender or body mass index, laterality of repair, associated procedures, or smoking history were noted between the groups. The aspirin group included older patients (mean age 49 yr) than those in the LMWH/apixiban group (mean age 39 yr).

Conclusions:
Aspirin alone may not be sufficient to prevent DVT after meniscus root repair. Additional work is required to clarify ideal DVT prophylaxis following this procedure.

Level of Evidence:
Level III.
A Scoping Review of Treatment Outcome Measures for Vulvar Intraepithelial Neoplasia
Authors: Jamieson Amy , Tse Samantha S. , Proctor Lily , Sadownik Leslie A. 
Published: September 2022

Objective
The goal of this study is to identify a list of clinician-reported outcome measures (CROMs) and patient-reported outcome measures (PROMs) through a review of published studies reporting on any therapeutic interventions for vulvar intraepithelial neoplasia (VIN).

Materials and Methods
A systematic search of published studies reporting on any therapeutic interventions for VIN was performed on MEDLINE, Embase, Cochrane Database, PsychInfo, and CINAHL from inception to September 20, 2021, based on predetermined study selection criteria. Data were extracted and analyzed by 2 authors independently using Covidence software.

Results
Thirty two of 2386 studies identified met study selection criteria. None of the 32 studies provided an explicit definition of VIN treatment “success.” The most common CROM was “clinical response to treatment.” The most common scale used to measure this outcome was “complete response/partial response/no response”; however, 17 of 23 studies (73.9%) did not define these values. Laboratory CROMs were reported in 12/32 (37.5%) studies. Patient-reported outcome measures were reported in only 10 of 32 studies(31.3%) —the most common PROM was “symptoms.” Only 2 of 32 studies measured PROMs related to “quality of life” domains. Adverse events/treatment-related adverse effects were reported in 24 of 32 studies (75%), although 71% of studies provided no details on how these data were collected.

Conclusions
There is a large variation in outcome measures, instruments, and scales used for any clinician-reported treatment outcome such as “clinical response.” Most studies do not include patient-reported outcome measures assessing quality of life domains. A Core Outcome Set for the treatment of VIN is needed to improve the quality of VIN research.
The Quality and Quantity of Lower Genital Tract Research Across Multiple Journals
Authors: Sheinis Michal , Macfarlane Megan , Selk Amanda 
Published: September 2022

Objective
This study aimed to determine the quantity and quality of lower genital tract disease (LGTD) research by topic published across a variety of gynecology and dermatology journals.

Methods
Authors accessed all articles that were rejected (1,111, 59.5%) and accepted (755, 40.5%) by the Journal of Lower Genital Tract Disease (JLGTD) from 2008 to 2020. Studies were categorized by key topic: Cervix, Human Papillomavirus, Vulva, Vagina, Anal, and Other. Studies were further subcategorized based on methodology. These data were compared with all LGTD publications from 2018 to 2020 in 4 other widely recognized journals (Obstetrics and Gynecology, The British Journal of Obstetrics and Gynaecology, JAMA Dermatology, and the British Journal of Dermatology).

Results
Most JLGTD-accepted submissions were related to the cervix (298/755, 39.5%) and vulva (189/755, 25.0%). Rates of acceptance were similar across all key topic areas. Only 3.2% of publications in the other 4 journals (92/2,932) were related to LGTD topics. Across all 5 journals, vulva studies were most commonly case reports/case series (82/218, 37.6%), with a low prevalence of systematic reviews/meta-analyses (4/218 1.8%). In comparison, cervix studies had the highest number of systematic reviews/meta-analyses (14/317, 4.4%) and the lowest number of case reports (14/317, 4.4%).

Conclusions
Vulvar research is of lower quality compared with cervix research published across 5 journals. Comparing accepted versus rejected articles in JLGTD, there is no publication bias against vulva topics noted; rather, the overall research quality in vulva is lower than that of cervical disease. This is a call to action for higher quality vulvar research.
Evaluating the impact of personalized rehabilitation nursing management in the perioperative nursing of patients with intracranial aneurysm: A protocol for systematic review and meta-analysis
Authors: Wang Qiong , Qiu Wei 
Published: September 2022

Background:
Patients who suffer from aneurysmal subarachnoid hemorrhage continue to die at a high rate, despite large geographical and risk factor-related variability in death rates. Hemorrhagic stroke has a greater death rate than ischemic stroke, which is often permanent, although patients who survive have less impairment than those who do not. Because of this, nurses must offer appropriate nursing care throughout the perioperative period for patients suffering from this prevalent neurological condition. Patients with intracranial aneurysms (IA) will be the subjects of this research, which will be carried out to thoroughly investigate the effect of tailored rehabilitative nurse treatment throughout the perioperative period.

Methods:
The influence of customized rehabilitative nurse management in the perioperative nursing of patients with IA has been studied in both randomized controlled trials and observation studies, according to the authors. From the time of the database’s creation until February 2022, information about studies will be gathered from 3 Chinese databases (Wanfang, China National Knowledge Infrastructure, and Chinese BioMedical database) and 4 English databases (PubMed, EMBASE, Cochrane Library, and CINAHL database). After the data extraction and risk of bias evaluation of the included studies are completed, the data synthesis will be carried out using the RevMan 5.3 program. Egger’s regression test and funnel plots will be used to determine whether or not there is any publication bias. The I2
statistics will be used to determine the degree of heterogeneity. A sensitivity analysis will be conducted to determine the robustness as well as stability of our results and conclusions.

Results:
This research is anticipated to offer high-quality evidence of tailored rehabilitative nurse treatment in the perioperative nursing of patients with IA.

Conclusion:
Results of this research will synthesize the current data to determine whether or not tailored rehabilitation nursing treatment may enhance the surgical recovery of patients with IA.
Reliability of blood tests taken from the peripheral intravenous catheter
Authors: Ben Shabat Idan , Ben Shabat Michal Hoffman , Ben Abraham Shai , Sagy Iftach , Tsaban Gal , Cohen-Lahav Merav , Goldinger Gil , Peled Michal , Bartal Carmi 
Published: September 2022

We aimed to compare the reliability of laboratory blood tests using 2 sampling methods, via a peripheral venous catheter (PVC) vs direct venipuncture stab (DVS), we evaluated the effect of time elapsed since PVC insertion, PVC diameter, and administration of saline and/or antibiotic infusion through PVC on the blood test results.
A prospective comparative study was conducted between May 2018 and July 2019. Patients aged ≥ 18 years and admitted to our department with a 20G/22G PVC inserted within the last 24 hours were enrolled.
Blood samples were collected from each participant in the morning, and a second sample was drawn using PVC. Dependent variables included the percentage of hemolysis, failure rate, complete blood count, biochemical testing parameters, and coagulation functions.
A total of 211 patients participated in the study. In total, 237 blood tests were conducted, of which 167 were performed on day 1 and the remaining on day 2, with a second blood sample collected from 26 patients on day 2. Twenty-one participants received 22G PVC, and 23 participants received active infusion. No significant differences were found in failure rates when each subgroup was compared with the primary day 1 group. The intraclass correlation coefficient indicated significant correlations among all the indices in all groups.
Both blood sampling methods (PVC and direct venipuncture) can be used interchangeably for routine laboratory tests on days 1 and 2 after PVC insertion using 20G/22G PVC or infused PVC.
Retrospective study assessing the efficacy of i.v. dexamethasone, SNRB, and nonsteroidal treatment for radiculopathy
Authors: Shahien Radi , Beiruti Wiegler Karine , Dekel Lior , Sharabi-Nov Adi , Abu Saleh Saad 
Published: September 2022

Retrospective study.
The purpose of this study was to investigate the clinical symptomatology of discopathies before and 7 days after treatment with one of the following: intravenous dexamethasone, selective nerve root block (SNRB), and systemic treatment with different nonsteroidal antiinflammatory drugs (NSAIDs).
Radiculopathy is a clinical condition in which dysfunction of one or more nerves occurs due to mechanical compression and/or chemical irritation of the nerve roots. Most often located in the lumbar spine, radiculopathy remains one of the most common complaints in primary health. Some patients responded well to conservative treatment. However, those who show no improvement may benefit from more invasive treatment options, such as intravenous corticosteroids, spinal injections, and surgical procedures.
We conducted a retrospective study of 81 male and female patients aged 18 years and above who had radicular pain and were referred to our facility over a 7-year period. Of the 100 patients assessed for eligibility, 19 patients were not included in the study due to malignancy or surgical intervention, 32 patients received intravenous dexamethasone, 24 patients received SNRB, and 25 received various NSAIDs as the control group. The visual analog scale, straight leg raise test and neurological deficits were assessed to evaluate the patients before and after receiving treatment. All patients underwent spinal computed tomography to confirm the diagnosis of disc herniation. Pearson chi-squared test, Kruskal–Wallis test, and Mann–Whitney test were used to evaluate the results.
Visual analog scale scores and the ability to perform straight leg raise test significantly improved after treatment with dexamethasone, SNRB, and NSAIDs. However, clinical improvement was significantly better in both the dexamethasone and SNRB groups than in the control group. Motor deficits improved significantly after dexamethasone treatment alone.
Dexamethasone and SNRB are useful and safe treatment options for treating patients with acute radicular pain. Randomized, double-blinded, control studies are warranted.
Association of human papillomavirus vaccination with cervical cancer screening: A systematic review and meta-analysis
Authors: Ssentongo Paddy , McCall-Hosenfeld Jennifer S. , Calo William A. , Moss Jennifer , Lengerich Eugene J. , Chinchilli Vernon M. , Ba Djibril M. 
Published: September 2022

Introduction:
Prophylactic vaccination and routine screening are effective at preventing most cases of cervical cancer. Globally, cervical cancer is the fourth most frequently diagnosed cancer among women. The aim of this study was to investigate the association between human papillomavirus virus (HPV) vaccination (1, 2, or 3 doses) and cervical cancer screening.

Methods:
PubMed (MEDLINE), Scopus, Web of Science, and Cochrane Library electronic databases were systematically searched from July 1, 2006, up to September 30, 2021. We pooled estimates using random-effects models. Heterogeneity between studies was quantified using Cochran Q test and I2
statistics. In total, 12 studies involving 2.4 million individuals were included in the meta-analysis.

Results:
In the adjusted estimates, uptake of HPV vaccination was associated with increased cervical cancer screening (pooled relative risk [RR]: 1.35; 95% confidence interval [CI]: 1.21, 1.50; n = 12). Between-study heterogeneity was large (I2
= 99%). Compared to unvaccinated, those who received 3 doses of HPV vaccine had the highest uptake of cervical cancer screening (RR: 1.85; 95% CI: 1.58, 2.17), followed by those who received 2 doses (RR: 1.34; 95% CI: 1.21, 1.47). No statistically significant association with screening was found for those who received a single dose of the HPV vaccine.

Conclusion:
In this meta-analysis, uptake of HPV vaccination was associated with higher cervical cancer screening. It is plausible that vaccinated individuals are more likely to engage in preventive health behaviors. Healthcare providers should remind patients to continue with routine screening for cervical cancer regardless of their HPV vaccine status since vaccination does not protect against all HPV types.
Laparoscopic surgery combined with the double-J tube implantation for the rare cystic-solid schwannoma of seminal vesicle: A Case Report and Literature Review
Authors: Lin Canbin , Liang Aidi , Liang Shulin , Wang Xiao , Meng Lei , Chen Ming 
Published: September 2022

Rationale:
Schwannoma is common in young and middle-aged people and occurs in the head, neck, posterior mediastinum, and retroperitoneal. Schwannoma, on the other hand, is a rare occurrence in the seminal vesicle. Early diagnosis and treatment are crucial since the disease can cause lower abdominal pain, nocturia, frequent urination, blood sperm, and other symptoms. There is no standard diagnostic or treatment guideline for seminal vesicle schwannomas currently. Therefore, the treatment experience relies on the few cases reported throughout the world.

Patient concerns:
A 45-year-old male patient discovered that the tumor beside the right side spermatophore is bigger than 3 years ago.

Diagnosis:
Schwannoma of seminal vesicle.

Interventions:
Ureter double-J tube implantation and laparoscopic surgery for schwannoma of seminal vesicle.

Outcomes:
The operation process went smoothly. And the patient was no discomfort after half a year.

Conclusion:
Schwannoma of the seminal vesicle is very rare in the clinic, and the imaging examination was not conclusive. The diagnosis mainly depends on pathological results. Surgical resection is the best treatment method for schwannoma. In surgery for schwannoma of seminal vesicle, combined with the ureter double-J tube implantation are many benefits. This case is an excellent example of the seminal vesicle schwannomas.
Identification of a pyroptosis-related prognosis gene signature and its relationship with an immune microenvironment in gliomas
Authors: Xiao Shengying , Yan Zhiguang , Zeng Furen , Lu Yichen , Qiu Jun , Zhu Xiaodong 
Published: September 2022

Background:
Glioma is the most common type of primary brain cancer, and the prognosis of most patients with glioma is poor. Pyroptosis is a newly discovered inflammatory programmed cell death. However, the expression of pyroptosis-related genes (PRGs) in glioma and its correlation with prognosis are unclear.

Methods:
27 pyroptosis genes differentially expressed between glioma and adjacent normal tissues were identified. All glioma cases could be stratified into 2 subtypes based on these differentially expressed PRGs. The prognostic value of each PRG was evaluated to construct a prognostic model.

Results:
A novel 16-gene signature was constructed by using the least absolute shrinkage and selection operator Cox regression method. Then, patients with glioma were divided into low- and high-risk groups in the TCGA cohort. The survival rate of patients in the low-risk group was significantly higher than that in the high-risk group (P = .001). Patients with glioma from the Gene Expression Omnibus (GEO) cohort were stratified into 2 risk groups by using the median risk score. The overall survival (OS) of the low-risk group was longer than that of the high-risk group (P = .001). The risk score was considered an independent prognostic factor of the OS of patients with glioma. Gene ontology and Kyoto Encylopedia of Genes and Genomes analysis showed that the differentially expressed PRGs were mainly related to neutrophil activation involved in immune responses, focal adhesion, cell cycle, and p53 signaling pathway.

Conclusion:
PRGs could predict the prognosis of glioma and play significant roles in a tumor immune microenvironment.
Case report: apatinib plus selexipag as a novel therapy for pulmonary tumor thrombotic microangiopathy accompanied by pulmonary hypertension associated with gastric carcinoma
Authors: Ma Guofeng , Wang Dan , Xu Xiaoling , Liang Li , Xu Li 
Published: September 2022

Rationale:
PTTM is a rare but fatal disease, characterized by endothelial intimal proliferation and pulmonary hypertension due to micro-vascular remodeling. In view of the poor prognosis, new effective strategies are urgently required.

Patient concerns and diagnosis:
A 51-year-old woman was admitted to hospital for acute progressive dyspnea and dry cough. Clinical tests revealed hypercoagulable state and signs of severe pulmonary hypertension, without evidence of pulmonary embolism on contrast-enhanced CT. CT showed interlobular septal thickening and diffuse ground-glass opacity. Lung perfusion scan indicated multiple segment defect. Further right heart catherization proved a significant increase in pulmonary vascular resistance.

Interventions:
A combination therapy of apatinib and selexipag was administered for treatment of PTTM. The conventional therapies of ventilation, anticoagulation and diuretic medicines were initiated after admission.

Outcomes:
Symptoms of PTTM were ameliorated with a reduction in pulmonary artery pressure. The resolution of interlobular septal thickening and ground-glass opacity on CT constituted the clinical benefits from treatment.

Lessons:
Patient with PTTM will benefit from the combination strategy of apatinib, a VEGF-receptor antagonist, and selexipag, an oral prostacyclin receptor agonist.
Advanced lung cancer patient with isolated heparin-induced thrombocytopenia: A case report
Authors: Yu Kai , Jiang Hui , Han Li-hua , Tong Zhi-ying , Wang Wan-min , Shang Yan , Zhao Jia-yi 
Published: September 2022

Rationale:
Heparin-induced thrombocytopenia (HIT), a potentially devastating form of drug-induced thrombocytopenia, occurs in patients receiving heparin for thrombosis prevention or treatment. An isolated HIT is characterized by decreased platelet counts without thrombosis, which are atypical and difficult to clinically find.

Symptoms and clinical findings:
A 33-year-old female patient’s admission examination revealed elevated D-dimer levels. After prophylactic anticoagulation using low-molecular weight heparin, her blood platelet counts were rapidly decreased, whereas her D-dimer levels increased, followed by presentations of chest tightness, abdominal pain, and skin itching without thrombosis. After excluding all the other causes of thrombocytopenia, HIT was suspected. Her 4Ts score was 5 points, and enzyme-linked immunoassay for platelet factor 4 (PF4)/heparin antibodies was positive, indicating isolated HIT.

Diagnoses, interventions, and outcomes:
The patient was diagnosed with advanced lung cancer presenting with isolated HIT. We immediately stopped low-molecular weight heparin and initiated rivaroxaban for anticoagulation. We administered thrombopoietin (TPO) and avatripopal maleate tablets to increase blood platelet counts, whereas intravenous immunoglobulin (IVIG) was administered to stimulate her immune system. The patient’s thrombocytopenia was successfully treated without thrombosis and bleeding complications.

Lessons:
Rivaroxaban is a potential option for tumor preventive anticoagulation and HIT treatment. Early HIT identification is necessary. After identification, the 4Ts score as well as PF4/heparin antibodies should be assessed and appropriate anticoagulants selected based on patients’ conditions.
Impact factors of POCUS-guided cannulation for peripheral venoarterial extracorporeal membrane oxygenation: One single-center retrospective clinical analysis
Authors: Chen Yanzhu , Chen Jiehuan , Liu Chaofan , Xu Zhirong , Chen Yi 
Published: September 2022

We aimed to evaluate associated factors for point-of-care ultrasound (POCUS)-guided percutaneous catheterization for venoarterial extracorporeal membrane oxygenation (VA-ECMO).
VA-ECMO cases from March 2018 to October 2020 in Department of Intensive Care Unit, Binhaiwan Central Hospital of Dongguan, were enrolled. Clinical data, outcomes, and complications were recorded and summarized.
Fifty-nine cases were enrolled, among which 88.1% succeeded in POCUS-guided catheterization via Seldinger technique, whereas 59.3% succeeded at the first puncture. Results showed that artery diameter and times of arterial punctures were independent associated factors for Seldinger puncture (P = .018, odds ratio [OR] = 23.374, 95% confidence interval [CI] = 1.706–320.270; P = .031, OR = 145.098, 95% CI = 1.592–13220.980), and artery diameter and cardiac ejection fraction value (≥30%/<30%) were independent associated factors for first puncture (P = .044, OR = 1.622, 95% CI = 1.014–2.596; P = .013, OR = 5.565, 95% CI = 1.441–21.488). For extracorporeal cardiopulmonary resuscitation patients, artery diameter was independent associated factor for Seldinger puncture (P = .022, OR = 2.070, 95% CI = 1.110–3.858), and cardiac ejection fraction value (≥30%/<30%) was independent associated factor for first puncture (P = .007, OR = 9.533, 95% CI = 1.847–49.204). Thirteen patients (22.0%) had local hemorrhage post puncture, 8 patients (13.6%) presented distal limb arterial ischemia, and 8 patients (13.6%) suffered puncture-related thrombosis. Vasoactive Inotropic Score was found to be independent associated factor for local hemorrhage (P = .039, OR = 0.994, 95% CI = 0.988–1.000), and the Acute Physiology and Chronic Health Evaluation II score was independent associated factor for thrombosis (P = .025, OR = 0.935, 95% CI = 0.882–0.992). Diabetes and cardiopulmonary resuscitation time before catheterization were independent factors for distal limb ischemia (P = .026, OR = 220.774, 95% CI = 1.905–25591.327; P = .017, OR = 1.054, 95% CI = 1.009–1.101).
POCUS-guided percutaneous catheterization via Seldinger technique can be the first choice for VA-ECMO cannulation, especially for a team without angiotomy qualifications. Before cannulation, evaluating the target artery and heart function by ultrasound can help predict outcome of catheterization. Assessing risk factors (diabetes, cardiopulmonary resuscitation time before catheterization, Vasoactive Inotropic Score, the Acute Physiology and Chronic Health Evaluation II score) is helpful for prevention and treatment of complications.