bluuebunny/crossref_metadata_2025_split huggingface dataset:
“F*ck Earth”: Unmasking Mars Colonization Marketing, from Planetary Perceived Obsolescence to Apocalyptic “New Earth” Rhetoric
Authors: Taylor Sarah McFarland 
Published: November 2022

Abstract
This article argues that, in promoting Mars colonization, SpaceX founder Elon Musk’s marketing strategies effectively tap into powerful and culturally resonant Christian-inflected, otherworldly, apocalyptic millennial tropes embedded in American culture. SpaceX’s messaging engages in a second-order appropriation of entwined Christian, colonial, frontierist, and imperialist themes that saturate works of astrocolonial science fiction. Musk and many of his followers are devoted fans of these works and draw inspiration from their endemic romanticized, utopian, space expansionist narratives in order to fuel the project of Mars colonization. In deploying popular marketing techniques, such as “manufactured urgency,” “perceived obsolescence,” “scarcity marketing,” “exploding offers,” and “argument dilution,” Musk prophetically stresses the existential urgency of planetary exodus. As Mars gets rebranded as “Earth 2.0,” the strategic use of apocalyptic “Mars as New Earth” visual and verbal rhetoric activates troubling dynamics that effectively legitimize siphoning off Earth’s remaining fragile resources in order to feed the colonial and corporate interests of a technocratic billionaire elite. This article dissects the religio-cultural providential resonances of otherworldly escape and manifest destiny evoked in Mars colonization marketing, while urging public media interventions into that marketing’s grossly misleading messaging.
Retracing the Works of KJICL: A Decade’s Journey
Authors: Kim Angela Semee , Lee Seryon 
Published: November 2022

Abstract
Over the past decade, the development and dynamics of international law have been prominent. The Korean Journal of International and Comparative Law (KJICL) played an active role in providing relevant and significant topics and issues of international law in its journal. The year 2022 marks the 10th anniversary of the KJICL. On this special occasion, we looked back on the key milestones in the journal’s history and explored the works of international law scholars and practitioners from around the world on a broad range of topics in international law. KJICL has reflected the developments and changes in international law by providing analysis and insights on timely topics and addressing the issues pertaining to Korea. The following highlights the distinctive and valuable works featured in KJICL over the last decade.
Legal Indigeneities: Identity, Authenticity, and Power in Taiwan’s Indigenous Courts
Authors: Upton J. Christopher 
Published: November 2022

Abstract
In this article I examine performances of Indigeneity in encounters between Indigenous people and the Taiwan legal system. Studying displays of Indigenous identities reveals the processes through which individuals and communities draw upon histories and practices to fashion themselves as Indigenous and engage with wider publics through performances and performative acts. Focusing on three encounters between Indigenous people and the Taiwan legal system, displays of Indigeneity in these encounters were multivalent and involved a repertoire of creative performative acts as Indigenous actors used court spaces, like the new ad hoc Chamber of Indigenous Courts, to perform identities that confounded essentialist conceptions of Indigeneity, introduced alternative ontological parameters, and assumed state governance responsibilities. These performances suggest a contextually situated engagement with the postcolonial state where Indigenous identities are anchored in the past and forward-looking, reinforce or challenge the category of Indigeneity, and themselves operate as techniques of power.
Research Methods Used in Evidence-Based Design: An Analysis of Five Years of Research Articles From the HERD Journal
Authors: Battisto Dina , Li Xiaowei , Dong Jiaying , Hall Luke , Blouin Julia 
Published: November 2022

Objective: This study aims to analyze research methodologies from 157 research articles published in this journal in the last five years (2016–2020). Background: Health environments research is comprised of research covering many topics and from various disciplines worldwide. No systematic study exists to uncover themes in evidence-based design (EBD) research concerning the types of research published, people engaged in research, and the research methods employed. Understanding the nature of health environment research performed can help researchers, practitioners, and students situate their work within an EBD research structure. Methods: Case study research was used to analyze 157 articles published in the Health Environments Research & Design Journal devoted to EBD and research. Secondary data were extracted to capture research methods from health environments studies and then analyzed to identify themes. The design and outcome categories were structured around and the Center for Health Design’s (CHD) Knowledge Repository with origins to Ulrich et al.’s Evidence-Based Design Framework. Results: Findings are reported on categories commonly found in empirical research articles: (i) key words, (ii) disciplines from authors, (iii) settings studied, (iv) populations studied or sampled, (v) research approach and study design, (vi) research strategies, (vii) data collection methods, (viii) data analysis procedures, (ix) design categories and variables, and (x) outcome categories and variables. Conclusions: The analyses highlighted the research methods most frequently used in health environments research. Findings revealed several inconsistencies across articles on key words and the framing of research methodologies. Results suggest that there should be a consistent and overarching research taxonomy with a set of acceptable terms for effective literature searches.
Acute effects of regional heat stimulation by indirect moxibustion on cardiovascular responses
Authors: Nakahara Hidehiro , Kawai Eriko , Miyamoto Tadayoshi 
Published: November 2022

AbstractMoxibustion is a traditional East Asian medicine treatment that involves burning moxa directly or indirectly on or near the skin at a specific site of the body, called an acupoint. However, whether moxibustion induces cardiovascular responses by modulating autonomic nervous activity remains unknown. The purpose of this study was to elucidate the effects of indirect moxibustion on cardiovascular responses and autonomic nervous activity. Fifteen healthy volunteers participated in the study. Each subject received regional heat stimulation by indirect moxibustion at the lower leg acupoint. Heart rate, RR intervals, blood pressure and skin temperature were measured continuously for 3 min at rest and 5 min during indirect moxibustion. Local skin temperature increased reaching a peak (45.3 ± 3.3 °C) at 2 min after moxibustion was started, and was accompanied by a significant decrease in heart rate (63.0 ± 7.8 to 60.8 ± 7.8 bpm, p < 0.05) together with a significant increase in root mean square difference of successive RR intervals. Regional heat stimulation by indirect moxibustion induced bradycardic response, which was modulated by autonomic nervous system.
Trajectories of mobility difficulty and falls in community-dwelling adults aged 50 + in Taiwan from 2003 to 2015
Authors: Kuo Fang-Lin , Yen Chia-Ming , Chen Hung-Ju , Liao Zih-Yong , Lee Yen 
Published: November 2022

Abstract
Background
A decline in mobility leads to fall occurrence and poorer performance in instrumental activities of daily living, which are widely proved to be associated with older adults' health-related quality of life. To inform potential predicaments faced by older adults at different age levels, predictors of this mobility change and falls along with the ageing process need to be further evaluated. Therefore, this study examined the risk factors associated with the longitudinal course of mobility difficulty and falls among community-dwelling middle-aged and older adults in the Taiwanese community.

Methods
We evaluated data for the period between 2003 and 2015 from the Taiwan Longitudinal Study on Aging; the data cover 5267 community-based middle-aged and older adults with approximately 12 years of follow-up. In terms of mobility, the participants self-reported difficulties in mobility tasks (eg, ambulation) and whether they used a walking device. We employed linear mixed-effects regression models and cumulative logit models to examine whether personal characteristics are associated with mobility difficulty and falls.

Results
Mobility difficulty significantly increased over time for the participants aged ≥ 60 years. Perceived difficulties in standing, walking, squatting, and running became apparent from a younger age than limitations with hand function. The probability of repeated falls increased significantly with older age at 70 (p = .002), higher level of mobility difficulty (p < .0001), lower cognitive status (p = .001), living alone (p = .001), higher number of comorbid illnesses (p < .001), walking device use (p = .003), longer time in physical activities (p < .011), and elevated depressive symptoms (p = .006). Although walking aid use increased the probability of falls, individuals with mobility difficulty had a reduced probability of repeated falls when using a walking device (p = .02).

Conclusion
Community-dwelling Taiwanese adults face an earlier mobility difficulty starting in 60 years old. Individuals with more leisure and physical activities in daily life were more likely to maintain mobility and walking safety. Long-term, regular, social, and physical activity could be a referral option for falls prevention program. The use of a walking device and safety precautions are warranted, particularly for individuals with walking difficulties.
Prognostic markers in patients with chronic lymphocytic leukaemia on targeted therapy, chemoimmunotherapy with anti-CD20 monoclonal antibody: a systematic review and meta-analysis of prognostic factors
Authors: Mkhwanazi Zekhethelo A. , Nyambuya Tawanda M. , Mfusi Snenhlanhla A. , Nkambule Bongani B. 
Published: November 2022

AbstractCombination chemoimmunotherapy (CIT) consisting of anti-CD20 has improved the progression-free survival (PFS) and overall survival (OS) of patients with chronic lymphocytic leukaemia (CLL). We performed a comprehensive synthesis of prognostic factors in patients with CLL on combined CIT with anti-CD20 antibodies compared with standard chemotherapy alone or targeted therapy.We searched the MEDLINE and academic search complete electronic databases as well as clinicaltrials.gov (from inception up to 01 August 2022) for randomised controlled trials examining chemoimmunotherapy and targeted therapy in patients with CLL. The risk of bias and the quality of evidence was assessed using the quality in prognostic studies tool (QUIPS).A total of 10 prognostic factors were identified and evaluated in patients with CLL on anti-CD20 antibody-containing CIT. The predictive value of the following prognostic factors was confirmed and associated with poor patient outcomes; deletion 17p (HR = 3.39), Immunoglobulin heavy chain variable region gene mutation status (HR = 0.96) and β2-microglobulin (HR = 1.41).Conventional predictive factors may have retained prognostic value and could be useful in the stratification of patients who may be non-responsive to CIT.Trial registration: International Prospective Register of Systematic Reviews (PROSPERO) registry (CRD42021218997).
Anticancer traits of chimeric antigen receptors (CARs)-Natural Killer (NK) cells as novel approaches for melanoma treatment
Authors: Bahmanyar Maryam , Vakil Mohammad Kazem , Al-Awsi Ghaidaa Raheem Lateef , Kouhpayeh Seyed Amin , Mansoori Yaser , Mansoori Behnam , Moravej Ali , Mazarzaei Abdulbaset , Ghasemian Abdolmajid 
Published: November 2022

AbstractOwing to non-responsiveness of a high number of patients to the common melanoma therapies, seeking novel approaches seem as an unmet requirement. Chimeric antigen receptor (CAR) T cells were initially employed against recurrent or refractory B cell malignancies. However, advanced stages or pretreated patients have insufficient T cells (lymphopenia) amount for collection and clinical application. Additionally, this process is time-consuming and logistically cumbersome. Another limitation of this approach is toxicity and cytokine release syndrome (CRS) progress and neurotoxicity syndrome (NS). Natural killer (NK) cells are a versatile component of the innate immunity and have several advantages over T cells in the application for therapies such as availability, unique biological features, safety profile, cost effectiveness and higher tissue residence. Additionally, CAR NK cells do not develop Graft-versus-host disease (GvHD) and are independent of host HLA genotype. Notably, the NK cells number and activity is affected in the tumor microenvironment (TME), paving the way for developing novel approaches by enhancing their maturation and functionality. The CAR NK cells short lifespan is a double edge sword declining toxicity and reducing their persistence. Bispecific and Trispecific Killer Cell Engagers (BiKE and Trike, respectively) are emerging and promising immunotherapies for efficient antibody dependent cell cytotoxicity (ADCC). CAR NK cells have some limitations in terms of expanding and transducing NK cells from donors to achieve clinical response. Clinical trials are in scarcity regarding the CAR NK cell-based cancer therapies. The CAR NK cells short life span following irradiation before infusion limits their efficiency inhibiting their in vivo expansion. The CAR NK cells efficacy enhancement in terms of lifespan TME preparation and stability is a goal for melanoma treatment. Combination therapies using CAR NK cells and chemotherapy can also overcome therapy limitations.
Self-reported medication information needs among medication users in a general population aged 40 years and above – the Tromsø study
Authors: Walquist Mari J. , Svendsen Kristian , Garcia Beate H. , Bergmo Trine S. , Eggen Anne Elise , Halvorsen Kjell H. , Småbrekke Lars , Ringberg Unni , Lehnbom Elin C. , Waaseth Marit 
Published: November 2022

Abstract
Purpose
To determine the prevalence and associated factors of self-reported medication information needs among medication users in a general population aged 40 years and above – The Tromsø Study.

Methods
Cross-sectional study of medication users (n = 10,231) among participants in the Tromsø Study, a descriptive analysis of questionnaire data and multivariable logistic regression (n = 9,194).

Results
Sixteen percent of medication users expressed a need for more information about own medications. Overall, medication users agreed to a higher degree to have received information from the GP compared to the pharmacy. Concerned medication users and those disagreeing to have received information about side effects had the highest odds for needing more information (OR 5.07, 95% CI 4.43–5.81) and (OR 2.21, 95% CI 1.83–2.68), respectively. Medication users who used heart medications (e.g., nitroglycerin, antiarrhythmics, anticoagulants) (OR 1.71, 95% CI 1.46–2.01), medication for hypothyroidism (OR 1.36, 95% CI 1.13–1.64) or had moderately health anxiety had expressed need for medication information. Whereas medication users with lower education, those that never used internet to search for health advice, and medication users who disagreed to have received information about reason-for-use were associated with lower odds (OR 0.75, 95% CI 0.62–0.91), (OR 0.85, 95% CI 0.74–0.98) and (OR 0.68, 95% CI 0.53–0.88), respectively.

Conclusion
This study demonstrated that there is need for more information about own medications in a general population aged 40 years and above and shed light on several characteristics of medication users with expressed information need which is important when tailoring the right information to the right person.
Which style of duodenojejunostomy is better after resection of distal duodenum
Authors: Liu Wenshuai , Wang Jiongyuan , Ma Lijie , Zhuang Aobo , Xu Jing , He Junyi , Yang Hua , Fang Yuan , Lu Weiqi , Zhang Yong , Tong Hanxing 
Published: November 2022

Abstract
Background
Distal duodenal resections are sometimes necessary for radical surgery, but how to restore duodenal continuity is still unclear. This study aimed at determining which style of anastomosis was more suitable for the duodenojejunostomy after resection of distal duodenum.

Patients and methods
We retrospectively identified 34 patients who underwent distal duodenum resection at our center between January 2014 and December 2021. According to whether the end or the side of the proximal duodenum was involved in reconstruction, duodenojejunostomy were classified as End style (E-style) and Side style (S-style). Demographic data, clinicopathological details, and postoperative complications were analyzed between two groups.

Results
Thirteen patients (38.2%) received E-style duodenojejunostomy, and 21 patients (62.8%) received S-style duodenojejunostomy. Comparative analysis showed that in group of E-style, patients had a lower rate of multivisceral resection(5/13 vs 18/21; P = 0.008), delayed gastric emptying (DGE) (1/13 vs 11/21; P = 0.011) and intraperitoneal infection (2/13 vs 12/21; P = 0.03). In this study, the incidence of major complications was up to 35.3% (12/34) and no patient died of complication in perioperative period. In two group, there was no difference in the incidence of major complications (E-style vs S-style: 3/13 vs 9/21; P = 0.292).

Conclusions
The E-style duodenojejunostomy for the reconstruction of distal duodenum resection is safe and feasible. The E-style anastomosis may have potential value in decreasing the occurrence of complications such as DGE and intraperitoneal infection, and the definitive advantages still need to be verified.
A novel method of lateral closing wedge osteotomy for cubitus varus deformity in children
Authors: Su Yuxi , Xie Yan , Nan Guoxin 
Published: November 2022

Abstract
Background
Humeral osteotomy is the best method for treatment of severe cubitus varus in children. Many osteotomy methods have been developed in the past. In this study, we describe a novel corrective technique by applying the principles described by Paley involving lateral osteotomy using Kirschner wires (K-wires). Vertices of the osteotomy should be located at the center of rotation of angulation. The anatomical and mechanical axes can be corrected with precision.

Patients and methods
In this retrospective study, 21 patients (17 male, 4 female) who fulfilled the study criteria and underwent lateral closing osteotomy for cubitus varus deformity from July 2015 to October 2017 were included into the study. The osteotomy line of all patients was designed according to Paley’s principles. An isosceles triangle template was made according to the design preoperatively. The lateral osteotomy was made with the assistance of C-arm radiographs. The osteotomy was fixed by K-wires laterally. Patients were followed up, and elbows were evaluated by radiography and using the Mayo Elbow Performance Index (MEPI) score.

Results
The mean correction angle obtained was 32.33°±2.83°. According to the MEPI score assessment, 19 of the 21 patients had an excellent outcome and two had a good outcome. Two patients complained of conspicuous scars; however, no further cosmetic surgery was performed. The range of motion was 135.0° preoperatively and 133.7° postoperatively, showing no significant difference (p = 0.326). None showed evidence of neurovascular injury or complained of prominence of the lateral humerus.

Conclusion
Paley’s principles for correcting cubitus varus deformity in children are effective and reliable for treating such a condition.

Level of evidence
Therapeutic IV.
A study on initiation of postpartum family planning in India based on NFHS-4: does urban poor differ significantly from rural?
Authors: Srivastava Ujjaval , Pandey Arvind , Singh Pragya , Singh Kaushalendra Kumar 
Published: November 2022

Abstract
Objective
To explore the differentials of postpartum contraceptive adoption between rural and urban poor after adjusting for utilization of MCH services and other selected socioeconomic and demographic covariates.

Methods
The data for this study is taken from the 4th round of NFHS survey conducted in India during 2015–16. The analysis is limited to 125,340 currently married women whose menses had returned at the time of survey. Discrete time complementary log–log multilevel model was applied.

Results
The results clearly indicate that women from rural areas had a lower chance of early initiation of modern spacing methods after having recent birth as compare to that of Urban Poor and Urban non-poor areas. The contributions of several socioeconomic and demographic characteristics that were important for family planning practice were also highlighted in this study.

Conclusion
There is an urgent need of designing an intervention that will result in effective delivery of services to achieve the greatest impact. Policy planners must focus on targeted interventions for family planning use in the postpartum period than simply focusing on family planning.