bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of Cdc37 ameliorates arthritis in collagen-induced arthritis rats by inhibiting synoviocyte proliferation and migration through the ERK pathway
Authors: Sun Weiwei , Mao Xingxing , Wu Weijie , Nan Yunyi , Xu Chunxiang , Wang Youhua , Xu Hua 
Published: September 2022

Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to synovial inflammation, pannus formation, cartilage damage, bone destruction, and ultimate disability. Fibroblast-like synoviocytes (FLS) are involved in the pathogenetic mechanism of RA. Cdc37 (Cell division cycle protein 37) is regarded as a molecular chaperone involved in various physiological processes such as cell cycle progression, cell proliferation, cell signal transduction, tumorigenesis, and progression. However, the precise role of Cdc37 in the pathogenesis of rheumatoid arthritis (RA) remains uncertain. In our study, we found that Cdc37 expression was upregulated in human rheumatoid synovia in contrast with the normal group. Interestingly, Cdc37 activated the ERK pathway to promote RA-FLS proliferation and migration in vitro. Ultimately, in vivo experiments revealed that silencing of Cdc37 alleviated ankle swelling and cartilage destruction and validated the ERK signaling pathways in vitro findings. Collectively, we demonstrate that Cdc37 promotes the proliferation and migration of RA-FLS by activation of ERK signaling pathways and finally aggravates the progression of RA. These data indicated that Cdc37 may be a novel target for the treatment of RA.
Facile synthesis of HKUST-1-cellulose filter for water purification from meloxicam
Authors: Mohammadnejad Masoumeh , Roshan Arezoo , Geranmayeh Shokoofeh 
Published: September 2022

Abstract
The main purpose of this study is designing and manufacturing a water treatment filter using metal-organic framework to remove pollutants from aqueous solutions with high efficiency. A uniform layer of the metal-organic framework was placed on cellulose filter paper. Cellulose filter paper is biodegradable, economical and its surface can be easy modifiable due to its high hydroxyl groups. For modification, a monolithic layer of the metal-organic framework was assembled on cellulose filter paper. HKUST-1 is a kind of MOFs with a porous and adjustable structure as well as having many active sites was selected for modification of cellulose filter paper for increasing the removal efficiency. The important point of this research is using very easy method to synthesis of the filter in a short time and at room temperature. HKUST-1@Filter paper was characterized by SEM, FTIR, and XRD analysis. This synthesized filter was used to remove meloxicam from the aqueous solution with a removal percentage more than 87%. To study the stability and reusability of the synthesized filter, an organic solvent was used for desorption, and it was found that the filter still remains stable and has high efficiency to remove contaminants for several times after desorption. Langmuir and Freundlich's isotherms were used to investigate the adsorption mechanism. With the equilibrium adsorption isotherm, it was found that the absorption of meloxicam followed the Langmuir model and the maximum adsorption capacity was 2500 mg g− 1.
A Cryptographic Algorithm using Polynomial Interpolations for Mitigating Key-Size Based Attacks
Authors: kaur jagpreet , K.R. Ramkumar 
Published: September 2022

Abstract
Confidentiality is one of the fundamental aspects to consider while securing wireless communication. Endeavouring current developments will catch up with the conventional cryptographic methods soon than expected; therefore, a new path is indispensable. In this context, this article presents an innovative idea of using polynomials to achieve a higher level of data privacy. Polynomials' strength lies in their irreducible property, which makes them plausibly appropriate for cryptography. Thenceforth, two novel schemes are proposed based on root-finding polynomial interpolations such as Bisection, Newton-Raphson, and Secant. Relying on these techniques, while the first scheme performs substitution, the BI-New scheme performs substitution, rotation, replacement, and substitution. Hence, both schemes provide confusion and diffusion, a fundamental security aspect. Besides, these algorithms utilise initial points to extract the exact root of the polynomial p1(y) =0. On the basis thereof, an algorithm is developed to retrieve the initial data points. Consequently, the decryption is accomplished in reverse order by evaluating a function. The proposed scheme has unique characteristics, including non-linear interpolating polynomials, roots of non-linear algebraic equations, and non-linear functions. Due to the amalgamation of various non-linear methods and randomised variables, the methods are one-way functions that can endure several assaults. Lastly, the algorithm's security is illustrated by multiple state-of-the-art quantitative metrics such as time complexity, accuracy, memory usage, key space analysis, key sensitivity analysis, robustness analysis, and statistical analysis.
Research on Apple Origins Classification Optimization Based on Least Angle Regression in Instance Selection
Authors: Li Bin , Wang Yuqi , Li Lisha , Liu Yande 
Published: September 2022

Abstract
The combined near-infrared spectral analysis technology and machine learning is widely used in fruit quality detection. The train set split from the heavy sample set contains redundant samples, and modeling directly may cause larger errors. Instance selection methods can be used to improve the performance of the raw train set by optimally selecting the effective samples. So, the least angle regression-based instance selection (LARIS) method was proposed to improve the model accuracy of fruits classification in this paper, an experiment was conducted on a total of 952 apples from four origins. Before splitting, the spectral reconstruction methods were used for preprocessing and the 19 outliers were eliminated by statistics. The sample set partitioning based on joint x-y distance (SPXY) was used to split the sample set into the raw train set of 699 samples and the test set of 234 samples. 511 samples with a compression ratio of 26.90% and the random train set with the same compression ratio were built based on training samples. Compared these classifiers trained by three train sets, the model’s accuracy established by the optimal train set is 96.6%, which are 4.7% and 6.4% higher than the raw and random train sets. And the average precision and recall of four origins are higher 6% than the raw and random train set. Therefore, the prediction accuracy of apple origins classification model is improved by LARIS. The LARIS method enriches the application and it provides an experimental support for the least angle regression algorithm in instance selection.
FBXW7 as a potential prognostic biomarker for ESCC inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells
Authors: Yang Yanfang , Bi Yanghui , Cheng Caixia , Tang Peisen , Xiao Heng , Yuan Fajia , Wu Weiwei , Yang Bin 
Published: September 2022

Abstract
Background Esophageal cancer is a gastrointestinal tumor with high morbidity and mortality worldwide. FBXW7, is an aboriginal and high frequency mutant gene associated with ESCC. However, the current understanding of its clinical significance and mechanism in ESCC is not comprehensive.
Methods Our previous data from WGS / WES and TCGA databases were used to analyze the clinical significance of FBXW7 in ESCC. Gene function and PCR-array were performed to explore the potential mechanism of FBXW7 in ESCC.
Results The clinical information analysis revealed that low expression of FBXW7 is associated with poor prognosis in ESCC patients. Especially in those age≤55 years old, without drinking history and T3 stage, low expression of FBXW7was associated with poor prognosis. In addition, we found that overexpression of FBXW7 inhibited cell proliferation, migration, invasion and angiogenesis, and promoted cell apoptosis. PCR-array results showed that overexpression of FBXW7 resulted in a variable spectrum of tumor-associated gene expression in esophageal squamous cell carcinoma cells. Significant changes in gene expression related to angiogenesis, DNA damage repair, and cell senescence were observed. The changes of these pathway genes may be related to the regulation of FBXW7 on the stemness of ESCC tumor cells.
Conclusions Our study investigated a novel role and mechanism of FBXW7 in esophageal squamous carcinoma and opened up new ideas for the clinical treatment of esophageal squamous carcinoma.
The Impact of Perceived Social Support on Mental Health Stigma and Professional Help-Seeking Behavior among College Teachers in Kerala,India
Authors: R Harikrishna M R Harikrishna M , Thomas Tissy Mariam Thomas Tissy Mariam , George Samuel George Samuel 
Published: September 2022

Abstract
Teaching is a profession, and teachers play numerous responsibilities in shaping generations. The traditional teaching environment was altered during the COVID-19 pandemic, and the new learning and evaluation methods and the new way of interacting with others led to a slew of mental health issues. The present study investigates the impact of perceived social support and mental health stigma on the professional help-seeking behavior of college-level teachers in Kerala, India. Participants (N = 130) were chosen through purposive sampling from various colleges throughout Kerala. The Attitude towards Seeking Professional Psychological Help Scale, Stigmatizing Attitude Believability Scale, and Multidimensional Scale of Perceived Social Support were administered to participants to assess professional help-seeking behavior, mental health stigma, and perceived social support. Spearman rank correlation coefficient, linear regression, and moderation analysis were used to analyze the relationship between variables. The findings obtained in the present study depicted a strong positive relationship between perceived social support and professional help-seeking behavior. Furthermore, perceived social support is a positive predictor of professional help-seeking behavior, while mental health stigma is found to be a negative predictor of professional help-seeking activity. The association between mental health stigma and professional help-seeking behavior is also moderated by perceived social support. The present study's findings contribute to understanding the significance of teachers' emotional and mental health well-being in the covid era. The findings shed light on the role of perceived social support as a facilitator that improves teachers' mental health.
Finite Element Modelling of Corneal Biomechanics Assessment Using Ultrasonic Elastography
Authors: Ahmed Hassan M. , Salem Nancy M. , Al-Atabany Walid , Al-Atabany Walid 
Published: September 2022

Abstract
Corneal diseases affect corneal tissue shape and its biomechanics leading to a degradation ofthe overall vision quality. Refractive surgeries restore corneal refractive power. However, its outcomes arehighly dependent on corneal biomechanics pre-surgery while changing corneal biomechanics post-surgery.Cornea behavior is obtained by estimation of corneal biomechanics pre- and post-refractive surgeries eitherex- or in-vivo. Demand for non-invasive in-vivo measurement is highly recommended as it preserves bothcorneal shape and structure on contrary to invasive ex-vivo methods. Until now no clinically reported in-vivodevice offering corneal biomechanics spatial distribution exists. In this research, ultrasonic noninvasive invivomeasurement for estimating corneal biomechanics using FEM simulation is proposed. Eleven differentelastic moduli FEMs are used to cover the range of elasticity of human cornea in normal and pathogenicstatus. Two ultrasonic tissue deformation measurement methods are used in this study. Namely, the radialShear Wave Speed (rSWS) and Focal Peak Axial Deformation (FPAD). rSWS utilizes two B-mode framerates; 10kHz and 100KHz typically. FPAD uses 100KHz for tissue deformation data collection. Twomathematical formulae for prediction of non-involved data points are power formula and logarithmic formulaare used. Simulation results shown that rSWS is efficient for high frame rate transducer. Accuracy of99.8%±2.4% is achieved with 100KHz while for 10KHz the accuracy is 95.5%±29%. Results shown also,that accuracy at 100KHz is nearly stable on contrary to highly fluctuating accuracy at 10KHz. FPAD shownthat logarithmic formula is optimum with Mean Square Error (MSE) of 0.006, compared to MSE of 0.09 forpower formula. FPAD has an advantage over rSWS to be implemented with low frame rate transducers whilerSWS has the advantage of quantitative measurement. Maximum temperature rise of 0.9 C is achieved dueto the ARFI where this value is under the FDA regulation.
Renal effects of 7,8-Dihydroxyflavone in cafeteria diet-induced obesity
Authors: Peker Emine Gulceri Gulec , Cirrik Selma , Hacioglu Gulay , Sahin Elif , Alver Ahmet 
Published: September 2022

Abstract
Objective: In this study, the possible protective effect of 7,8-Dihydroxyflavone (7,8-DHF), a brain-derived neurotrophic factor (BDNF) mimetic and anti-oxidant flavonoid, in renal damage caused by cafeteria diet-induced obesity was investigated.
Method: In the study, 4-5 week old C57BL/6 male mice were used and the subjects were divided into 4 groups as Control, CD (cafeteria diet), CD+Vehicle and CD+7,8-DHF (n=9-11). Control group subjects were fed with chow diet for 16 weeks and other groups were fed with cafeteria diet. In the last 28 days of the feeding period, 7,8-DHF treatment (5 mg/kg/day, intraperitoneal) was administered in the CD+7,8-DHF group, and DMSO (17%) as a 7,8-DHF carrier was administered in the CD+Vehicle group. At the end of 16 weeks, the subjects were sacrificed and malondialdehyde (MDA), reduced glutathione (GSH), nitrite + nitrate (NOx) and collagen levels, and superoxide dismutase (SOD) and catalase (CAT) enzyme activities were measured in kidney tissues.
Results: At the end of 16 weeks, body weights of all subjects increased compared to baseline. Weight gain was higher in CD (p<0.001) and CD+Vehicle groups (p<0.001) compared to control. The weight gain in the CD+7,8-DHF group was not different from the control. Compared to the CD group, the weight gains in the CD+Vehicle and CD+7,8-DHF groups were lower. Compared to the control group CD group had higher renal MDA level (p<0.0001), lower GSH level (p<0.0001), less SOD (p<0.0001) and CAT (p<0.0001) activity, lower NOx (p<0.0001) and collagen (p<0.0001) levels. Vehicle administration did not affect these parameters as results were similar to CD group. However, significant changes were noted with 7,8-DHF treatment. Compared with the CD+Vehicle group, the CD+7,8-DHF group had lower MDA levels (p<0.001), higher GSH levels (p<0.001), lower NOx levels (p<0.001), higher SOD (p<0.001) and CAT (p<0.001) activities. 7,8-DHF treatment brought these parameters closer to the control values, but did not fully return to control, except for CAT activity. Renal collagen deposition was not affected by 7,8-DHF treatment.
Conclusion: Oxidative stress plays an important role in obesity-induced renal damage. 7,8-DHF may be important in the suppression of renal damage in cafeteria diet-induced obesity, at least by inhibiting oxidative stress and excessive nitric oxide production. The increasing prevalence of eating habits and obesity together with the cafeteria diet in the society, makes these results clinically important. These effects of 7,8-DHF need to be investigated in more details.
Clinically applicable 39 genes targeted mutational analysis predicts recurrence in pediatric medulloblastoma: a monocenter cohort study
Authors: Zhang Zaiyu , Wu Yuxin , Li Lusheng , Zhai Xuan , Liang Ping 
Published: September 2022

Abstract
Purpose
Targeted mutational analysis has been widely used to predict medulloblastoma molecular subgroups. We aimed to identify a gene mutation pattern for individual recurrent risk assessment patients with medulloblastoma.
Methods
In this monocenter cohort analysis, patients who experienced medulloblastoma recurrence were analyzed for clinical outcomes, including anatomic and temporal patterns of relapse and post-recurrence survival. Differentially mutational genes were examined using a panel of 39 genes to build a gene classifier using an elastic net regression model. The Cox proportional hazards model was used to estimate the multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the prognostic accuracy of this gene classifier.
Results
A total of 23 of 118 (21%, 95% CI: 12.8–27.8) patients experienced recurrence, with a significant representation of patients in the very high risk group. Most patients exhibited some distal disease 56% (34.9–75.6). Time to relapse and post-recurrence survival did not vary by risk stratification. A recurrent gene signature for medulloblastoma that consisted of 27 genes was generated to classify patients into high and low recurrence risk groups. Patients with high recurrence risk scores had shorter recurrence-free survival (hazard ratio [HR]: 24.304, 6.277–29.723) and overall survival (HR: 7.331, 2.957–18.172) than patients with low-risk scores. These findings of sensitivity analyses suggest that the current results did not change substantially.
Conclusion
The recurrent score is a reliable prognostic tool for recurrence in patients with medulloblastoma. It can potentially guide treatment decisions for patients at different risks of recurrence.
Protective role of Nebivolol via Akt/Hif-1α/eNOS signaling pathway: Nephrotoxicity caused by Methotrexate in a rat model
Authors: KARAKUYU Nasıf Fatih , ERTUNÇ Onur , BEDİR Mehmet , DOĞAN Hatice Kübra , TANER Rümeysa , Sevük Mehmet Abdulkadir , İMECİ Orhan Berk , ERGÖNÜL Esin 
Published: September 2022

Abstract
Methotrexate (MTX) is an antineoplastic and anti-inflammatory agent which is used in serious diseases. Its use should be limited due to side effects such as nephrotoxicity, myelotoxicity and hepatotoxicity, especially during high doses in cancer treatment. Hypertension may accompany patients due to nephrotoxicity, which is shown as one of the most important side effects. Nebivolol (NBV), which is a beta blocker and used in the treatment of hypertension, also contributes to vasodilation in tissues by activating endothelial nitric oxide synthase (eNOS) enzyme. The purpose of this study is to research the effect of NBV on MTX-induced nephrotoxicity through the AKT1/Hif-1⍺/eNOS signaling pathway. The rats were randomly divided into three groups of eight each. Groups were control, MTX and MTX + NBV. A single dose of 20 mg/kg MTX was given intraperitoneally to the rats on the first day of the study and 10 mg/kg NBV was given orally to the treatment group for seven days. At the end of the study, rats' blood and kidney tissues were taken for histopathological, immunohistochemical and biochemical examinations. Total antioxidant status levels were increased and total oxidant status levels were decreased significantly in MTX + NBV group compared with MTX group. Although creatinine levels increased in the MTX group compared to the control, while decreased in the MTX + NBV group. MTX administration was significantly decreased the expression levels of AKT1, eNOS and Hif1α compared to control group and NBV treatment increased these values compared to MTX group. In conclusion, NBV treatment ameliorated the MTX induced nephrotoxicity via AKT1/Hif-1⍺/eNOS signaling pathway.
Regulatory Network after Intracerebral Hemorrhage
Authors: Jin Sinan , Meng Jincheng , Zhang Chong , Wu He 
Published: September 2022

Abstract
Intracerebral hemorrhage (ICH) has a high mortality and disability rate. As it is difficult to obtain brain tissue of patients occurred ICH, the mechanism research carried out primarily through animal experiments, and the translational medicine progresses slowly. More effective therapeutic targets and reliable regulatory networks for ICH are needed. We detected the expression levels of mRNAs, miRNAs and circRNAs before and after ICH, then added lncRNAs to obtain a more complete regulatory network. Subsequently, an original mRNA data in human peripheral blood after ICH from the GEO database was obtained. After analyzing the differential expressed mRNAs of the data, it was intersected with the mouse data. Then seven genes have been found to have made significant changes in both humans and mice after ICH. Finally, these gene regulatory networks in humans were analyzed. By comparing species, we provided signaling pathways for the human and mouse homologous in these regulatory networks. Hoped that some of them might become early warning signals of the ICH. Finally, the tendency of change in RNA levels of the above seven genes was checked after ICH in the mouse brain, in order to provide more valuable data.
Food Hygiene Management among Food Handlers of Chitwan Nepal- Pre –Post Study Design
Authors: Khanal Gayatri , Shrestha Niki , Shrestha Sarbada , Chapagain Shakuntala , Chhetri Mamta 
Published: September 2022

Abstract
Background: Improper food handling practices are one of the major single causes of unsafe food, which can cause more than 200 diseases. Maintaining food hygiene largely depends on factors such as unhygienic practices, insufficient sanitation, inadequate cooking, improper storage, and cross-contamination which can be controlled by adequate knowledge and proper practice of food handlers. Hence, this study was conducted to evaluate the effectiveness of an awareness program on safe food handling practices among food handlers.
Methods: A pre-post study was conducted in Chitwan district among 38 food handlers to evaluate the effectiveness of the educational intervention. G Power version 3.1.9.7 software is used to calculate sample size. The data collection tool was a semi-structured questionnaire. Data were entered using Epi-data 3.1 software and analysed using SPSS 16. The statistical analysis carried out was descriptive and bivariate (Wilcoxon Rank Test).
Results: 68.4% of respondents were handling food without any formal education on food handling practices. 15.8% of café/restaurants were running without a license or registration. 52.6% of food handlers had an unsatisfactory level of knowledge in the pre-test, whereas none of them were included under this category in the post-test. The median (IQR) post-test was higher than the median (IQR) pre-test score, which was statistically significant by applying the Wilcoxon sign rank test (p = 0.001).
Conclusions: Food hygiene management education for food handlers is an effective intervention for improving food hygiene knowledge and management. Food handler knowledge can be increased by encouraging food establishments/restaurants in various food safety education or training packages, thereby reducing foodborne outbreaks and food safety threats.