bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin-17 levels in gingival crevicular fluid of aggressive periodontitis and chronic periodontitis patients
Authors: Wankhede Anand Narayanrao , Dhadse Prasad Vijayrao 
Published: December 2022

Abstract

Context:
Interleukin-17 (IL-17) plays an important function in initiation, progression of any inflammatory condition. It is a pro-inflammatory cytokine and considered to be founding member. Periodontitis being an inflammatory condition of periodontium, IL-17 does have a potential role in periodontitis. The current research has shown positive correlation between the IL-17 and severity of periodontitis. Therefore, this research study aimed to evaluate the levels of IL-17 in aggressive periodontitis (AgP), chronic periodontitis (CP), and “healthy gingival sites.”

Materials and Methods:
A total of 45 selected subjects (90 samples) were equally divided into three different groups. Group 1 (Healthy gingiva on clinical examination): Subjects with healthy gingiva and no evidence of periodontal attachment level (PAL), probing pocket depth (PPD) <3 mm papillary bleeding index (PBI) <1. Group 2 (AgP): Subjects having age <35 years with at least six permanent teeth apart from the incisors and first molars with PPD and PAL ≥5 mm. Group 3 (CP): It consist of subjects with clinical features of inflammation of gingiva with minimum six teeth in each jaw, with PPD ≥4 mm, PAL ≥4 mm. IL-17 levels were analyzed by using Gingival crevicular fluid (GCF). It was collected from the sulcus of first maxillary molar sites for quantitative analysis.

Results:
GCF IL-17 levels in AgP were found to be 1.12 ± 0.29, 1.96 ± 1.71 in CP and 0.64 ± 0.23 in healthy gingival sites. Clinical parameters such as (1) plaque index (Turesky et al., modification of Quigley-Hein), (2) PPD, (3) PBI were higher (significantly) in periodontitis group as compared to healthy gingiva. Positive correlation was found to be significant between levels of IL-17 with PAL and PPD in AgP however in cases of CP, positive correlation of IL-17 levels was found only with PAL but not PPD.

Conclusion:
Our study shows that the IL-17 levels were comparatively higher in GCF of AgP, CP in comparison to healthy gingiva, but the GCF IL-17 levels were higher in CP as compared to AgP.
Evaluation of the efficacy of sticky bone and concentrated growth factor membrane along with a coronally advanced flap as compared to coronally advanced flap alone in the treatment of Miller’s Class I and Class II gingival recession defects
Authors: Mitra Dipika , Kandawalla Shazneen , Potdar Priyanka , Patil Shruti , Naniwadekar Amruta , Shetty Gaurav 
Published: December 2022

Abstract

Context:
Gingival recessions are commonly seen in the dentally cognizant population as well as those with limited access to dental attention. When root coverage is planned, the ultimate goal is to obtain complete root coverage, thus restoring the lost gingival unit covering the root.

Aims:
To determine the efficacy of sticky bone and concentrated growth factor (CGF) membrane along with a coronally advanced flap (CAF) as compared to CAF alone in treating Miller’s Class I and Class II gingival recessions (Cairo RT1).

Settings and Design:
The current study was a randomized double-blind controlled trial on 15 subjects using a split-mouth design.

Materials and Methods:
Fifteen subjects who were systemically healthy and had recession sites (30 sites) were randomly assigned to two groups: Group A (test group = CAF + CGF + sticky bone) and Group B (control group = CAF alone). Clinical outcome was assessed with parameters such as recession depth, recession width, keratinized gingival width, gingival mucosal thickness, and relative attachment level (RAL), and these were assessed at baseline and 1, 3, and 6 months.

Results:
A distinct improvement was observed in the depth and width of recession, RAL, keratinized gingival width, and mucosal thickness of the gingiva in the two groups from baseline to 6 months. Statistical significance was not seen on intergroup comparisons.

Conclusions:
Thus, clinical outcomes revealed noticeable improvement for both the groups. However, statistically, the efficacy of CGF and sticky bone was not perceived to be superior to that of CAF alone.
Host Factors and Risk of Pin Site Infection in External Fixation
Authors: Fridberg Marie , Bue Mats , Rölfing Jan Duedal , Kold Søren 
Published: December 2022

Introduction:
Host factors affecting pin site infections were selected by The Pin site Consensus Group, using a modified Delphi approach, to be one of the top 10 priorities to investigate how to reduce rates of pin site infections, improve clinical management, and inform research. The aim of this study was to perform a systematic literature review of the association between host factors and pin site infection, focused on age, smoking, body mass index, and comorbidities, in particular diabetes.

Materials and Methods:
The literature search strategy was developed as advised in the Cochrane Handbook for Systematic Reviews of Interventions following the PRISMA guidelines with the help from a scientific librarian. The protocol was registered in the International Register of Systematic Reviews, PROSPERO (ID: CRD42021273305). The literature search was executed in three electronic bibliographic databases, including Embase MEDLINE (1111 hits) and CINAHL (2066 hits) through Ovid and Cochrane Library CENTRAL (387 hits).

Results:
A total of 3564 titles were found. 3162 records were excluded by title and abstract screening. 140 studies were assessed for full-text eligibility. All excluded studies were not reporting specific numbers of patients with pin site infection and the associations of interest. 11 studies were included for data extraction. The included studies were all designed retrospective, and the risk of bias assessment was done using Joanna Briggs Institute risk appraisal tool. The extracted data are presented as results in tabular summaries. This review reveals an increased risk of pin site infection associated with increased HbA1C level in diabetic patients and congestive heart failure in diabetic patients. An increased risk of pin site infection was associated with a lower ASA score. None of the included studies found any association between pin site infection and smoking, age, or body mass index.

Conclusion:
This systematic literature search identified a surprisingly low number of studies examining the association between pin site infection and the specific host factors. Thus, this review most of all serves to demonstrate a gap of evidence about the correlation between host factors and risk of pin site infection, and further studies are warranted.
Preoperative Intralesional Bevacizumab Injection in Primary Pterygium in Tunisian Patients
Authors: Sayadi Jihene , Gouider Dhouha , Henchiri Meher , Choura Racem , Boujelbene Nadia , Abbes Imen , Khochtali Sana , Zghal Imene , Malek Ines , Khairallah Moncef , Nacef Leila 
Published: December 2022

Purpose:To assess the efficacy and safety of a single preoperative intralesional bevacizumab injection as an adjuvant treatment before primary pterygium surgery.Methods:We conducted a randomized controlled interventional study from January 2019 to December 2020. The study included a total of 60 patients (60 eyes) with primary pterygium. We defined two groups of 30 patients each. Group A received an intralesional injection of bevacizumab (Avastin), 1 month before surgery (lesion excision and conjunctival autograft). Group B (control) had only the surgical treatment. Patients were followed up 7 days (D7), 1 month (M1), 3 months (M3), and 6 months (M6) postoperatively. Pre-, per-, and postoperatively, photographs of the lesions were taken, as well as a histopathological examination. The main outcome measures were the change in functional discomfort following intralesional bevacizumab injection and pterygium recurrence. Recurrence was defined as fibrovascular tissue growth invading the cornea. Therapeutic success was defined as the absence of pterygium recurrence in M6.Results:The mean age of the 60 patients was 54.17 ± 10.53. After bevacizumab injection, the preoperative functional discomfort score decreased significantly (P= 0.048). There was a significant improvement in grade and color intensity (P= 0.001). We noted no local nor systemic complications after intralesional injection of bevacizumab. After pterygium excision, the success rate was statistically higher in Group A (P= 0.047). There was no significant difference in either final best-corrected spectral visual acuity or astigmatism between the two groups. We noted a statistically significant association between recurrence and color intensity (P= 0.046), vascular density (P= 0.049), and the degree of elastic tissue degeneration (P= 0.040).Conclusion:A single preoperative subconjunctival injection of bevacizumab 1 month before surgery decreases the vascularity of newly formed blood vessels and hence may reduce the recurrence rate.
Corneal Biomechanical Parameters after 60-Year-Old
Authors: Shokrollahzadeh Fereshteh , Hashemi Hassan , Yekta Abbasali , Ostadimoghaddam Hadi , Khabazkhoob Mehdi 
Published: December 2022

Purpose:To determine the distribution of corneal biomechanical parameters in an elderly population.Methods:This cross-sectional study was conducted in subjects above 60 years living in Tehran. The participants were selected using multi-stage cluster sampling. Corneal biomechanical parameters were measured in a randomly selected subsample of this population using the Reichert Ocular Response Analyzer (Reichert Ophthalmic Instruments, Inc., Buffalo, NY, USA).Results:Of 470 subjects, the data of 420 participants aged over 60 years were analyzed (mean age: 69.3 ± 6.5 years and range: 61–88 years), 363 (86.4%) of whom were male. The mean and standard deviation of corneal hysteresis (CH) and corneal resistance factor (CRF) were 8.37 ± 1.55 mmHg (95% confidence interval [CI]: 8.02–8.72) and 9.06 ± 1.70 mmHg (95% CI: 8.69–9.44), respectively. The mean CH was 8.27 ± 1.54 mmHg in men and 9.25 ± 1.28 mmHg in women, and the mean CRF was 9.00 ± 1.71 mmHg in men and 9.63 ± 1.37 mmHg in women. According to the results of multiple linear logistic regression analysis, CH had a significant association with younger age (β = −0.05,P= 0.032), female sex (β = 1.83,P< 0.001), reduced maximum keratometry (β = −0.22,P= 0.06), and increased anterior chamber volume (β = 0.01,P= 0.007). CRF had a significant correlation with a younger age (β = −0.06,P= 0.02), female sex (β = 1.01,P= 0.05), central corneal thickness (β = 0.02,P< 0.001), and reduced maximum keratometry (β = −0.39,P= 0.010).Conclusion:The mean CH and CRF values were low in this sample of the Iranian population aged over 60 years indicating the weaker elasticity of the corneal connective tissue.
Long-term Results of Congenital Cataract Surgery with Primary Intraocular Lens Implantation
Authors: Orazbekov Lukpan , Smagulova Sabina , Ruslanuly Kairat 
Published: December 2022

Purpose:
To analyze the results of ocular refraction at the age of 7 years in children after congenital cataract surgery with intraocular lens (IOL) implantation.

Methods:
A study of ocular biometric data of 143 eyes who underwent lens aspiration with IOL implantation in unilateral (23 eyes) and bilateral (60 eyes) congenital cataracts was performed. All children were divided into groups according to the age categories at the time of surgery: Group A (0–12 months) - 43 eyes; Group B (12–36 months) - 45 eyes; and Group C (older than 36 months) - 55 eyes. An empirical reduction of the implanted IOL power was performed: an undercorrection of 20% in children aged 0 to 36 months and 10% less in children aged 36 to 60 months.

Results:
By age 7 years, the mean elongation ± standard deviation (SD) in Group A was 3.93 ± 1.64 mm, 2.13 ± 0.94 mm in Group B, and 0.95 ± 0.76 mm in Group C (18.7%, 9.5%, and 4.1% of the baseline axial length, respectively). There was no significant difference in axial elongation between unilateral and bilateral congenital cataracts (P = 0.32). The mean absolute refraction error (MAE) at last examination was 3.99 ± 2.12 diopter (D), 2.46 ± 1.48 D, and 1.59 ± 1.31 D in Groups A, B, and C, respectively. In infants younger than 7 months of age, by age 7 years, the mean elongation ± SD was 3.27 ± 2.86 mm (25.5%) and MAE was 3.44 ± 2.1 D. The prevalence of preoperative corneal astigmatism of 1.0 D or more was 48.95%, 2.0 D or more was 27.27%, and 3.0 D or more was 5.6%. There was no significant difference in preoperative corneal astigmatism between unilateral (1.62 ± 0.77 D) and bilateral (1.78 ± 0.90 D) congenital cataracts (P = 0.56, 95% confidence interval = −0.50–0.28). Best-corrected visual acuity (BCVA) more than 20/40 was in 53.49%, 55.55%, and 74.54% in Groups A, B, and C, respectively.

Conclusions:
Although IOL power was calculated in accordance with children's age, at the age of 7 years, there was a different degree of ametropia because of the biometric changes of the growing eye, and a higher rate of ametropia was observed more in the younger age group than in the elder age groups.
Pituitary Apoplexy Secondary to Thrombocytopenia due to Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Authors: Aghdam Kaveh Abri , Abtahi Zahra-Alsadat , Sonbolestan Seyed Ali , Sanjari Mostafa Soltan 
Published: December 2022

Purpose:
To report a 16-year-old female patient with pituitary apoplexy in the setting of coronavirus disease 2019 (COVID-19) infection-related thrombocytopenia in the absence of preexisting pituitary macroadenoma.

Methods:
The patient had been admitted because of respiratory complications of COVID-19 infection and developed thrombocytopenia, intense headache, and symptoms of cavernous sinus syndrome.

Results:
Urgent magnetic resonance imaging of the brain depicted a pituitary apoplexy.

Conclusion:
This case indicated that thrombocytopenia due to COVID-19 could be a predisposing factor for pituitary apoplexy in the absence of underlying pituitary disease.
A Prospective Study to Determine the Safety and Efficacy of Contralateral Submandibular Gland-Sparing Radiation Therapy for Oral Cavity and Oropharyngeal Carcinoma
Authors: Bose Soumyo , Sharma Shyam , Manna Debojyoti , Biswas Linkon , Ghorai Suman 
Published: December 2022

Background and Aim:
The submandibular glands (SMGs) contribute 95% of daily salivary flow. Thus, SMG-sparing intensity-modulated radiation therapy (IMRT) may maximize patient-related xerostomia outcomes. However, sparing the SMG is technically quite challenging due to its small size and proximity with suspected disease harboring target lymph node groups. In this study, we assessed the effects of the contralateral SMG (cSMG)-sparing radiation therapy on the treatment outcome and on the xerostomia and other toxicities.

Materials and Methods:
Patients with squamous cell carcinoma of oral cavity and oropharynx with only unilateral neck node involvement were given cSMG-sparing IMRT either as definitive or postsurgery adjuvant therapy depending on the scenario. During radiotherapy, patients were followed up weekly and after completion of radiation at 6 weeks, 3 months, and at 6 months for assessment of treatment response and evaluation of xerostomia and other toxicities.

Results:
The mean dose to the cSMG was 33.68 Gy. Immediately after radiotherapy, 25.7% of patients had Grade 2 acute xerostomia which on subsequent follow-up on 3 and 6 months reduced to only 2.9%. In patients, who received postoperative radiotherapy with or without chemotherapy, no incidence of recurrence was noted in the entire follow-up period. About 57.1% of patients who received definitive concurrent chemoradiotherapy showed complete response after 6 months.

Conclusion:
In well-lateralized oropharyngeal and oral cavity carcinoma, cSMG-sparing IMRT can limit the incidence of xerostomia without compromising tumor control.
Methanolic Leaf Extract of Dryopteris dilatata Reverses Kidney Injury on Streptozotocin-Induced Diabetic Male Wistar Rats
Authors: Ajirioghene Akpotu Emamuzou , Ani Celestine Okafor , Ajebor Doris N , Elavieniso Alabarima Favour , Okolo Kenneth Obinna 
Published: December 2022

Background:
Hyperglycemia when sustained leads to diabetes which has become a chronic disorder having morbidity and mortality rate. This study investigated the effect of methanolic leaf extract of Dryoptersis dilatata (MEDd) on kidney injury caused on streptozotocin (STZ)-induced diabetic Wistar rats.

Materials and Methods:
Thirty Wistar rats were divided into five groups of six rats each. Group 1 received distilled water (10 ml/kg); Group 2 received STZ (60 mg/kg) only, Groups 3 and 4 received STZ followed by 400 and 800 mg/kg of MEDd, respectively, while Group 5 received STZ + Pioglitazone (10 mg/kg). After 2 weeks of treatment, rats were sacrificed and blood, spleen, liver, pancreas, and kidney were collected for biochemical analysis.

Results:
The results showed that MEDd extract caused a significant decrease (P < 0.05) in STZ-induced diabetic rats, oxidative stress markers, malondialdehyde nitric oxide, and glutathione superoxide were ameliorated in organs such as the kidney and pancreas in diabetic rats after treatment with MEDd. Kidney markers (urea and creatinine) were ameliorated as well as reduction in organ weights in diabetic rats following treatment with MEDd.

Conclusion:
Therefore, it was observed from our study that MEDd has antidiabetic and nephron-protective capacity as it ameliorates in vivo adopted in lieu of nephropancreatic caused by STZ-induced diabetes.
Anti-Ulcer Potentials of Aqueous Extract of Triticum aestivum on Delayed Healing of Experimentally Induced/Gastric Ulcer
Authors: Adebayo-Gege Grace Iyabo , Adetomiwa David Ayo , Omayone Tosan Peter , Akintayo Oloruntoba Christopher , Ozegbe Queen Bisi , Dimeji Igbayilola Yusuf , Ojo Oluwafemi Adeleke 
Published: December 2022

Background:
Ulcer reoccurrence and delay of healing caused by certain factors is now a major problem with the treatment of peptic ulcer. This study sought to unravel the role of Triticum aestivum in delayed ulcer healing in Wistar rats.

Materials and Methods:
Twenty five (25) Experimental animals (male Wistar rats) weighing 120g – 150g were randomly divided into five groups (N = 5) viz; I (Control), II (20% acetic acid ulceration + 2 mg/kg of indomethacin), III, IV, and V received 50 mg/kg, 100 mg/kg and 200 mg/kg of T. aestivum + 20% acetic acid ulceration + 2 mg/kg of indomethacin. Ulcer was induced by serosa application of 20% acetic acid and was delayed by subcutaneous administration of 2 mg/kg of indomethacin for 14 days.

Results:
Findings from this study showed that the relative body weight changes decreased substantially in delayed untreated group juxtaposed to control which was improved in T. aestivum extract (TAE) groups. Total gastric acidity, ulcer area, and relative stomach weight were substantially (P < 0.05) increased in delayed ulcer group juxtaposed to control group. These changes were substantially reversed in TAE-treated groups. A substantial decrease was observed in the catalase level and expression of nitric oxide accompanied by an increase in malondialdehyde was noted in delayed ulcer group juxtaposed to control which were ameliorated in all TAE treated groups. Histological and macroscopic evaluations revealed that there was a substantial decrease in inflammation and erosion of the gastric mucosa in groups treated with T. aestivum juxtaposed to delayed ulcer group.

Conclusion:
It can thus be said that aqueous extract of T. aestivum attenuates delayed gastric ulcer healing due to antioxidants and anti-inflammatory properties. The highest concentration (200 mg/kg) in this proved to be the most beneficial.
Glucose-6-Phosphate Dehydrogenase Deficiency and its Association with Malaria in the Administrative Divisions of Lagos State, Nigeria
Authors: Babalola Oladayo Musa , Alli Adetunji Alabi , Ashiru Mojeed Ayoola 
Published: December 2022

Background:
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of red blood cells' most common inherited enzyme disorders. It is currently believed to affect approximately 500 million individuals worldwide. The deficiency could result in several hematological conditions, including acute hemolytic anemia, neonatal jaundice, and kernicterus.

Aim:
This study aimed to determine the prevalence of G6PD deficiency in the five administrative divisions of Lagos State. The association between malaria and G6PD deficiency was also investigated.

Materials and Methods:
A total of 105 participants, comprising 63 (60%) males and 42 (40%) females, were recruited from five locations for this study. Two milliliters of venous blood were collected and divided into three portions for G6PD enzyme assay, hematological parameter, and malaria diagnosis. G6PD enzyme level was determined using a quantitative spectrophotometric assay, whereas the malaria parasite was examined using microscopy and rapid diagnostic test kits.

Results:
An overall prevalence of G6PD deficiency was 21%. There was no significant difference in prevalence between males (22.2%) and females (19%), whereas a marginally higher G6PD activity in males (10.15 ± 0.50 vs. 8.61 ± 0.31 U/g Hb) (P < 0.05) was recorded. Although there were slight differences in prevalence obtained in the five sampling locations, however, the one-way analysis of variance of the G6PD activity levels showed no significant difference between any pairs (P = 0.05). Furthermore, the results obtained from this study showed no association between malaria and G6PD deficiency (χ
2 = 1.432, P = 0.231).

Conclusions:
The study found a relatively high prevalence of G6PD deficiency in the Nigerian subpopulation, indicating that G6PD deficiency is common in this environment. This emphasizes the need for a quantitative G6PD assay as part of laboratory investigations for those presenting with an episode of acute hemolytic anemia in this geographical region of the country.
El storydoing como modelo innovador de comunicación publicitaria que favorece una mejora en la sociedad
Authors: Rodríguez-Ríos Antonio , Lázaro Pernias Patrícia 
Published: December 2022

Introducción: Se analiza el storydoing como un modelo en publicidad prospectivo en términos de justicia social y de sostenibilidad medioambiental que responde a las necesidades de una sociedad que demanda más transparencia y honestidad a las organizaciones comerciales. Metodología: Una muestra compuesta por 87 campañas storydoing se ha sometido a un análisis de contenido cualitativo exploratorio. Dicho análisis ha consistido en identificar la causa social de la campaña a partir de las categorías establecidas por Kotler et al. (2002) y calcular su incidencia en la muestra. Resultados: Los resultados constatan que el storydoing es un modelo de comunicación publicitario que favorece una mejora en la sociedad a través de la educación en valores que atañen a la familia, la escuela, la adolescencia y la juventud, el civismo, la cultura y la política. Asimismo, en temas como la contaminación medioambiental y de los océanos, las especies en peligro de extinción y sobre el reciclaje. Discusión: Visto lo anterior, estamos ante un modelo en comunicación publicitaria que favorece una mejora en la sociedad. Ahora bien, algunos estudios señalan la poca claridad con la que las empresas desarrollan sus estrategias basadas en causas sociales. Conclusiones: Al final encontramos un modelo disruptivo educomunicativo en publicidad que basa su estrategia en un relato alineado a la realidad empresarial y que apuesta por la transformación de la realidad social.