bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study Protocol
Authors: Bhatia Rohit , Haldar Partha , Puri Inder , Padma Srivastava M.V. , Bhoi Sanjeev , Jha Menka , Dey Anupam , Naik Suprava , Guru Satyabrata , Singh Mamta Bhushan , Vishnu VY , Rajan Roopa , Gupta Anu , Vibha Deepti , Pandit Awadh Kishore , Agarwal Ayush , Salunkhe Manish , Singh Gunjan , Prasad Deepshikha , Panda Samhita , Anand Sucharita , Rohila Amit Kumar , Khera Pushpinder S. , Tiwari Sarbesh , Bhaskar S. , Garg Mayank , Kumar Niraj , Dhar Minakshi , Tiwari Ashutosh , Agrawal Naman , Raju Garuda Buchi , Garg Jyoti , Ray Biman Kanti , Bhardwaj Amit , Verma Alok , Dongre Nikhil , Chhina Gurpreet , Sibia Raminder , Kaur Rupinderjeet , Zanzmera Paresh , Gamit Amit , Iype Thomas , Garg Ravinder , Singh Sulena , Kumar Ashok , Ranjan Abhay , Sardana Vijay , Soni Dilip , Bhushan Bharat , Dhamija Rajinder K , Saluja Alvee , Bala Kiran , Dabla Surekha , Goswami Divya , Agarwal Abhimanyu , Shah Sudhir , Shah Shalin , Patel Mayank , Joshi Pranav , Awasthi Sanjiv , Nath Smita , Chandan Shishir , Malik Rupali , Chowdhury Neera 
Published: March 2022

Introduction:
In India, a national program for stroke (national programme for the control of cardiovascular diseases, diabetes, cancer, and stroke) and stroke management guidelines exist. Its successful implementation would need an organized system of stroke care in practice. However, many challenges exist including lack of awareness, prehospital notification systems, stroke ready hospitals, infrastructural weaknesses, and rehabilitation. We present here a protocol to investigate the feasibility and fidelity of implementing a uniform stroke care pathway in medical colleges of India.

Methods and Analysis:
This is a multicentric, prospective, multiphase, mixed-method, quasi-experimental implementation study intended to examine the changes in a select set of stroke care-related indicators over time within the sites exposed to the same implementation strategy. We shall conduct process evaluation of the implementation process as well as evaluate the effect of the implementation strategy using the interrupted time series design. During implementation phase, education and training about standard stroke care pathway will be provided to all stakeholders of implementing sites. Patient-level outcomes in the form of modified Rankin Scale score will be collected for all consecutive patients throughout the study. Process evaluation outcomes will be collected and reported in the form of various stroke care indicators. We will report level and trend changes in various indicators during the three study phases.

Discussion:
Acute stroke requires timely detection, management, and secondary prevention. Implementation of the uniform stroke care pathway is a unique opportunity to promote the requirements of homogenous stroke care in medical colleges of India.
Clinical profile of Kawasaki disease in children admitted at a tertiary care hospital of North India and their short-term follow-up
Authors: Banoo Nargis , Bashir Amber , Tariq Syed , Radhakrishnan Sitaraman , Abid Shaira 
Published: March 2022

Aim:
The aim of this study was to evaluate presenting symptoms, clinical features, and laboratory tests for the diagnosis of Kawasaki disease (KD) in children and their short-term follow-up at a tertiary care hospital of North India from April 2017 to March 2020.

Materials and Methods:
A total of 31 children (23 boys and 8 girls) up to 10 years of age were included in this study. The diagnosis of KD was made as per the American Heart Association 2017 guidelines. Clinical features, laboratory parameters, and coronary involvement were compared between the complete and incomplete KD groups.

Results:
The incidence of complete versus incomplete KD was 19 (61.2%) versus 12 (38.7%) children, respectively. Change in extremities and oral mucosal changes were more encountered in the complete KD group as compared to the incomplete KD group (100% vs. 58.3%, P = 0.004, and 78.9% vs. 33.3%, P = 0.002, respectively). Coronary artery aneurysm was seen in 54% of the patients on echocardiography which was greater in the incomplete KD group (83.3%) as compared to the complete KD group (36.8%). The median time from the onset of symptoms to intravenous immunoglobulin infusion was <10 days in 84.2% of the patients with complete KD versus 41.7% with incomplete KD which was statistically significant. Fifty percent of the children with coronary ectasia and small aneurysm had normal coronaries at follow-up of 6 months.

Conclusion:
KD is probably underdiagnosed in most developing countries, like that of ours, and requires a high index of suspicion.
Exercise-induced electrocardiographic changes after treadmill exercise testing in healthy children
Authors: Malakan Rad Elaheh , Karimi Mohsen , Momtazmanesh Sara , Shabanian Reza , Saatchi Mohammad , Asbagh Parvin Akbari , Zeinaloo Ali Akbar 
Published: March 2022

Background:
Treadmill exercise testing is a crucial diagnostic tool for evaluating congenital and acquired heart disease in the pediatric population. This study aimed to perform a comprehensive evaluation of exercise-induced electrocardiographic (ECG) changes in children. Although there are numerous studies on exercise testing in various cardiac pathologies, studies on exercise-induced ECG changes in normal children with coverage of all ECG parameters of atrial and ventricular depolarization and repolarization are very scant, if any.

Aims and Objectives:
This study aimed to investigate the exercise-induced ECG changes in healthy children and evaluate the effects of gender and four different formulas of heart rate correction of Bazett, Fridericia, Framingham and Hodges on ventricular repolarization parameters pre-and post-exercise.

Materials and Methods:
Between April 2019 and April 2020, all children with normal electrocardiogram, echocardiogram and exercise test, high-quality ECG tracings and consent for participation were enrolled in this prospective study. Twenty electrocardiographic parameters were measured and 25 indices were calculated. P-value < 0.05 was considered significant.

Results:
Seventy-four healthy children were studied. Amplitudes of P, S, and T waves increased significantly after the exercise. All durations, except P wave time to peak and T peak -T end /QT (Tp-e/QT) interval decreased significantly with exercise. Generally, the parameters of ventricular repolarization were not statistically significant between males and females. There were significant differences among the heart-rate corrected values of intervals of QTc, QoTc, JTc, J point to peak T and Tp-e/QTc by various formulas. There was no U wave either at pre-exercise or post-exercise. QT interval was shortened by 24.6 % ± 12.1 % with exercise. The ECG-derived estimated duration of mechanical systole and diastole decreased with exercise. The percentage of decrease in diastole was more than systole (43.79 %± 13.31% versus 33.74% ±15.79 %, respectively, P-value < 0.001).

Conclusion:
Diastolic time decreased more than systolic time with exercise and systolic time to diastolic time increased with exercise. Hodges' and Fridericia's formulas resulted in the longest and shortest QT and QoT, JT, and JTP, respectively. Thus, using a single value as the cut-off for long QT syndrome can lead to under or over-diagnosis. Nomograms incorporating data on age, heart rate, and heart rate correction formula are indispensable for accurate long QT diagnosis. Furthermore, gender differences in ventricular repolarization parameters are not generally present in 5 to 14-year-old healthy children. The lack of U wave in this study may implicate the need for more careful investigation in the presence of U wave in the treadmill exercise testing of healthy children.
Effect of the Coronavirus Disease 2019 Pandemic on Academics of Students Pursuing Masters of Occupational Therapy in Maharashtra State
Authors: Palsule Shilpshree Prashant , Khanna Henna Vijaypal 
Published: March 2022

Background:
Masters in occupational therapy (OT) is a 3-year course offered by the Maharashtra University of Health Sciences. Maharashtra was one of the worst affected states by the pandemic in 2020 and thus its impact on academics might show greater ill effects. This study was conducted with an objective to understand the health-care students' perspective of how the coronavirus disease 2019 (COVID-19) pandemic affected their present academic and clinical reasoning skills and what they think about their future career in OT. The literature also suggests that health-care students experienced stress during the COVID-19 pandemic, but hardly any study was conducted on OT students. Hence, this study was conducted to identify the students' perspectives on perceived stress and academics due to the pandemic situation.

Objectives:
The objective of this study is to understand students' perspective on academics and clinical reasoning skills and future career implications, and their stress levels. To understand how teaching/academics can or has bettered/improved during such time.

Study Design:
An observational cross-sectional study design was chosen for the research.

Methods:
The study protocol was approved by the Institutional Ethics Committee. A validated semi-structured questionnaire was circulated through Google Forms to all 56 2nd-and 3rd-year students pursuing Master of OT in Maharashtra. The form consisted of 17 questions. Questions were based on how the pandemic affected their academics and the major academic and clinical concerns that the students faced during this period. Student's written and informed consent was attached to the online questionnaire. In addition to this, students were asked to respond to the Perceived Stress Scale to understand their stress levels.

Results:
The pandemic had an impact on clinical assignment in all 29 (100%) students. Not having enough opportunity to explore their clinical posting during the pandemic was experienced by all 29 (100%) students. The students found a gap in transforming theory into the clinical assignments. Having additional time for academics was stated by 14 (48.2%) students. Severe stress was perceived by 5 (17.2%) students and moderate stress was perceived by 24 (82.7%) students.

Conclusion:
The study concluded that all students had an effect on their clinical assignments, which may be due to reduced footfall of patients among the first wave of COVID-19 pandemic. Students claimed to have additional time for academics due to reduced patient load.
TỔNG HỢP CÁC DẪN XUẤT MỚI CỦA 7-YDROXYL-5,3',4'-TRIMETHOXYFLAVONE TRÊN CƠ SỞ PHẢN ỨNG MANNICH THÔNG QUA SỰ HỖ TRỢ CỦA VI SÓNG VÀ HOẠT TÍNH ỨC CHẾ TĂNG SINH CỦA CHÚNG TRÊN DÒNG TẾ BÀO HELA
Authors: NGUYỄN VĂN SƠN  , VÕ THÀNH CÔNG  , NGUYỄN LẬP TRƯỜNG  
Published: March 2022

7-hydroxy-5,3',4'-trimethoxyflavone (1) là một flavonoid tự nhiên đã được tổng hợp từ hesperidin tự nhiên. Dựa trên phản ứng Mannich của 1 với các amine bậc hai khác nhau và formaldehyde. 11 dẫn xuất flavonoid mới (2-12) được tổng hợp thông qua sự hỗ trợ của vi sóng. Quá trình aminometyl hóa diễn ra ở vị trí ưu tiên tại C-8 của vòng A của 1. Hoạt tính ức chế tăng sinh tế bào ung thư cổ tử cung ở người (Hela) của các dẫn xuất được đánh giá thông qua phương pháp MTT tiêu chuẩn. Kết quả cho thấy các dẫn xuất thể hiện hoạt tính ức chế tăng sinh tế bào Hela tại nồng độ IC50 là 10.13-100 μM, trong đó các hợp chất 3, 6 và 10 có hoạt tính tốt hơn khi so sánh với chất đối chứng dương (DDP) cis-Platin. Cấu trúc của các dẫn xuất được xác định bằng một số phương pháp hóa lý hiện đại như NMR và MS.
Some problems of rule-making of the federal executive bodies
Authors: Голодов П.В. 
Published: March 2022

В статье рассматриваются отдельные вопросы качества и законности актов нормотворчества федеральных органов исполнительной власти, анализируется проблема обеспечения их надлежащего соотношения с законодательными актами. Автором приводится ряд конкретных примеров, подтверждающих существование данной проблемы. В числе основных недостатков отмечаются следующие: передача законом на подзаконный уровень решения вопросов, регламентация которых должна осуществляться на уровне законодательного акта; «вторжение» подзаконного нормотворчества в сферу законодательного регулирования, проявляющееся в создании так называемых норм первичного правового регулирования при отсутствии соответствующих законодательных норм или за пределами их фактического правового содержания. В целях решения рассматриваемой проблемы предлагается более широкое использование механизмов системы мониторинга правоприменения в Российской Федерации и системы общественной экспертизы нормативных правовых актов, а также цифровых технологий в нормотворческой работе федеральных органов исполнительной власти
The article examines certain issues of the quality and legality of acts of rule-making of federal executive bodies, analyzes the problem of ensuring their proper correlation with legislative acts. The author provides a number of specific examples confirming the existence of this problem. Among the main shortcomings are the following: the transfer by law to the subordinate level of the solution of issues which regulation should be carried out at the level of a legislative act; “intrusion” of bylaw rule-making into the sphere of legislative regulation, appeared in the creation of the so called norms of primary legal regulation in the absence of relevant legislative norms or beyond their actual legal content. In order to solve the problem under consideration, it is proposed to use more extensively the mechanisms of the law enforcement monitoring system in the Russian Federation and the system of public examination of regulatory legal acts as well as digital technologies in the rule-making work of federal executive bodies.
On some problems in the application of Art. 72 of the Criminal Code of the Russian Federation and possible ways of solving them
Authors: Белова С.Н. , Строгович Ю.Н. 
Published: March 2022

В статье на основе анализа отдельных норм законодательства в сфере уголовной юстиции рассматриваются причины, вызывающие неоднозначное и противоречивое применение положений ст. 72 Уголовного кодекса Российской Федерации о зачете в срок лишения свободы времени содержания под стражей в иностранных государствах лиц, выданных в Российскую Федерацию для уголовного преследования или исполнения приговора. Авторами сформулированы меры по решению данной проблемы.
Based on the analysis of certain provisions of the legislation in the field of criminal justice, the article examines the reasons for the ambiguous and contradictory application of the provisions of Art. 72 of the Criminal Code of the Russian Federation on offsetting into the term of imprisonment the time of detention in foreign states of persons extradited to the Russian Federation for criminal prosecution or execution of a sentence. The authors formulated measures to solve this problem.
Terms of functionality public oversight commissions as subjects of public control over the institutions of the penitentiary system of the Russian Federation
Authors: Кузнецова Е.В. , Кочетова Е.А. 
Published: March 2022

В статье предпринята попытка определить условия, при которых общественные наблюдательные комиссии как субъекты общественного контроля за деятельностью уголовно-исполнительной системы будут реализовывать поставленные перед ними цель и задачи. Авторы предлагают отказаться от понятия «эффективность деятельности» применительно к общественным наблюдательным комиссиям и оценивать их с позиции функциональности. Под функциональностью общественных наблюдательных комиссий предлагается понимать их способность выполнять свои функции. Выявляются следующие условия функциональности общественных наблюдательных комиссий: согласованное правовое регулирование их деятельности, оптимальный порядок формирования комиссий и подготовки их членов к деятельности, физическая доступность учреждений для посещения общественными наблюдательными комиссиями, надлежащее финансирование деятельности общественных наблюдательных комиссий
The article attempts to determine the conditions under which public supervisory commissions as subjects of public control over the penitentiary system will implement their goals and objectives. The authors propose to abandon the concept of "efficiency" in relation to public oversight commissions and evaluate them from the standpoint of functionality. It is proposed to understand the functionality of public oversight commissions as their ability to perform their functions. The authors identify the following conditions for the functionality of public oversight commissions: coordinated legal regulation of their activities, the optimal procedure for the formation of commissions and preparation of their members for activities, physical accessibility of institutions for visiting by public oversight commissions, proper funding for the activities of public oversight commissions.
Estudio sobre las motivaciones y los usos educativos que los jóvenes universitarios hacen de Facebook
Authors: Guerrero Katiuzka Flores , De la Madrid María Cristina López , Morales Diana Rojo 
Published: March 2022

Las redes sociales son una parte importante en la vida de los jóvenes, en donde encontraron un medio para expresarse y compartir con familiares y amigos de forma fácil y divertida. Pero, los usos que los jóvenes universitarios les dan a estás redes no se detienen allí, ya que también las utilizan en el ámbito escolar. Sin embargo, cuando una institución educativa desea incluir de manera formal a estas redes sociales en sus procesos educativos, resulta necesario realizar una investigación para conocer a ciencia cierta cómo sus estudiantes las utilizan, para aprovechar así las ventajas que brindan y evitar el fenómeno creepy treehouse que ocurre cuando se intenta invadir el espacio social de un joven. El presente trabajo muestra los resultados de un grupo focal que explora las motivaciones y usos que los estudiantes de un campus universitario hacen de la red social Facebook. Los resultados muestran que los estudiantes aprovechan las funcionalidades del Facebook en el ámbito educativo, tales como: a) la virtualidad para hacer trabajo colaborativo; b) la comunicación para asesorías con sus profesores, ponerse de acuerdo con sus compañeros en cuestiones de tareas y dar avisos; c) la facilidad para compartir y/o obtener recursos educativos subidos a la red por ellos mismos, compañeros y profesores; y d) la creación de grupos cerrados para trabajar exclusivamente con sus profesores, entre otros usos.
Urban rural differentials in spatial distribution of pregnant women’s choice of delivery place by district in Punjab — Results from Pakistan Social and Living Standards Measurements Survey 2014-15
Authors: Masood Ali Shaikh  
Published: March 2022

Madam, home deliveries are fraught with higher risks of maternal and neonatal complications, but in many developing countries childbearing women choose to deliver at home.1-3 Utilization of public or private maternal healthcare services is predicated on availability of, access to, and cost concerns. Public sector healthcare facilities are designed to essentially provide free services.1-3 In this study, percent of delivery sites utilization, disaggregated by urban and rural residency status in each district of the Punjab province were mapped using Geographic information Systems. The spatial distribution of delivery site percentages, disaggregated by three places of either home delivery, delivery at government facilities (hospital, Rural Health Center, and Basic Health Units), and delivery at private hospitals or clinics was done to highlight the urban and rural distribution, including the differences between urban and rural percentages.
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Konsep pengaturan pemberlakuan karantina wilayah (lockdown) saat Covid-19 meningkat di Indonesia
Authors: Kattsoff Thoby Araya , Kusuma Mahendra Wijaya , Haerunnisa Baiq Vidia , Hamdani Fathul , Fauzia Ana 
Published: March 2022

Sejak mewabahnya Corona Virus Disease 2019 (Covid-19) pada tanggal 2 Maret 2020, setidaknya hingga 18 Oktober 2021 ada sebanya 4.235.384 kasus terjangkit COVID-19, diikuti dengan jumlah laporan kematian mencapai 142.999 kasus. Penyebabnya adalah kurangnya kesadaran masyarakat dalam menggunakan masker sampai kepada kurang optimalnya penegakan hukum terhadap aturan protokol kesehatan pada masa pandemi Covid-19 di Indonesia. Untuk menekan penyebaran, sesuai dengan Undang-Undang Nomor 6 Tahun 2018 tentang Karantina Kesehatan diatur suatu kebijakan untuk mengatasi wabah/virus yang menular, salah satunya adalah Karantina wilayah atau Lockdown. Beragamnya budaya yang dimiliki Indonesia mengharuskan pemberlakukan lockdown menggunakan pendekatan yang mendukung adat istiadat pada tiap daerah dengan melibatkan tokoh adat setempat sehingga lockdown dapat berjalan dengan maksimal. Adapun metode penelitian yang digunakan dalam penelitian ini yaitu metode penelitian yuridis normatif. Dengan menggunakan pendekatan perundang-undangan dan pendekatan konseptual. Penelitian ini bertujuan memberikan analisa terkait bagaimana kemungkinan munculnya varian baru dan meningkatnya kasus Covid-19 di kemudian hari. Sehingga dibutuhkan pendekatan yang sifatnya refresif dengan memberlakukan karantina wilayah (lockdown).
Pendampingan Secara Online pada Ibu Muda dalam Praktik Pemberian Makanan Tambahan untuk balita
Authors: Sitoayu Laras , Pertiwi Rahmi Kartini , Tommy G Tommy G , Gultom Pelita Juliana , Dewanti Lintang Purwara , Gifari Nazhif 
Published: March 2022

The practice of complementary feeding (MP-ASI) to children still has many obstacles, starting from the schedule for giving it, the type and the amount that must be given according to the child's age. This causes nutritional problems in children, such as gastrointestinal infections, malnutrition, etc. One way to overcome errors in the practice of giving complementary feeding is to provide nutrition education by forming nutrition classes/groups for young mothers who have children under five. Education is carried out online to make it easier for mothers to follow education during the Covid-19 pandemic. Educational programs are effective in increasing mother's knowledge of the practice of giving MP-ASI. Praktik pemberian MP-ASI pada anak masih banyak mengalami kendala, mulai dari jadwal pemberiannya, jenis dan jumlah yang harus diberikan sesuai dengan usia anak. Hal ini menyebabkan timbulnya masalah gizi pada anak, seperti infeksi saluran pencernaan, gizi kurang, dsb. Salah satu cara mengatasi kesalahan dalam praktik pemberian MP-ASI adalah melakukan edukasi gizi dengan membetuk kelas gizi/grup pada ibu muda yang memiliki anak balita. Edukasi dilakukan secara online untuk memudahkan ibu dalam mengikuti edukasi di masa pandemi Covid-19. Program edukasi efekti meningkatkan pengetahuan ibu terhadap praktik pemberian MP-ASI.