bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of academic achievement in Dominican students: Mediational role of learning strategies and study habits and attitudes toward study
Authors: Reyes Betty , Jiménez‐Hernández David , Martínez‐Gregorio Sara , De los Santos Saturnino , Galiana Laura , Tomás José M. 
Published: August 2022

AbstractSchool or academic achievement is a relevant topic of study, as it is evidence of the learning achieved by the student. This study aims to explore a model explaining academic achievement while testing the mediator role of learning strategies, study habits and study attitudes. Research design was correlational. 1712 Dominican students from 12 to 20 years old (52.75% female) were sampled through cluster sampling. Data was recruited with a set of validated questionnaires, including measures of academic achievement (marks), learning strategies, study habits, and attitudes toward studies, school engagement, and academic support. Structural Equation Modeling was used to establish and test the mediational model. Main results show that learning strategies and study habits and attitudes play a mediator role between background variables as age, gender, cognitive or behavioral engagement, and students' academic achievement. Learning strategies and study habits play a central role in achieving a good academic performance, by mediating the effects of academic support and school engagement.
Insights into aggregation dynamics of NACore peptides from coarse‐grained simulations
Authors: Huang Rui‐jing , Tang Ran , Song Xiang‐yan , Wang Jing‐han , Chen Kang , Tian Wen‐de 
Published: August 2022

AbstractAlpha(α)‐synuclein is closely related to the pathogenesis of Parkinson's disease (PD). The NACore, a fragment of α‐synuclein, is considered to be the key region of α‐synuclein that causes PD. The aggregation dynamics of NACores are studied via coarse‐grained molecular dynamics simulations. We find that NACores can self‐assemble into a large cluster at high concentrations. The aggregation dynamics can be divided into three stages. The growth kinetics for the first and second stages follows the power law, Smax ~ tγ, with the second stage faster than the first one. The characteristic lifetime for the high concentration is 40 times larger than that for the low concentration, implying the low fluidity. Understanding the aggregation dynamics of NACores is helpful to develop drugs for therapeutic prevention and intervention.
Phase‐Controlled Synthesis of Nickel‐Iron Nitride Nanocrystals Armored with Amorphous N‐Doped Carbon Nanoparticles Nanocubes for Enhanced Overall Water Splitting
Authors: Chen Mingyu , Liu Ying , Fan Jiayao , Liu Bingxue , Shi Naien , Lin Yue , Li Xianzeng , Song Wenqi , Xu Dongdong , Xu Xiangxing , Han Min 
Published: August 2022

AbstractTransition metal nitrides (TMNs) nanostructures possess distinctive electronic, optical, and catalytic properties, showing great promise to apply in clean energy, optoelectronics, and catalysis fields. Nonetheless, phase‐regulation of NiFe‐bimetallic nitrides nanocrystals or nanohybrid architectures confronts challenges and their electrocatalytic overall water splitting (OWS) performances are underexplored. Herein, novel pure‐phase Ni2+xFe2−xN nanocrystals armored with amorphous N‐doped carbon (NC) nanoparticles nanocubes (NPNCs) are obtained by controllable nitridation of NiFe‐Prussian‐blue analogues derived oxides/NC NPNCs under Ar/NH3 atmosphere. Such Ni2+xFe2−xN/NC NPNCs possess mesoporous structures and show enhanced electrocatalytic activity in 1 m KOH electrolyte with the overpotential of 101 and 270 mV to attain 10 and 50 mA cm–2 current toward hydrogen and oxygen evolution reactions, outperforming their counterparts (mixed‐phase NiFe2O4/Ni3FeN/NC and NiFe oxides/NC NPNCs). Remarkably, utilizing them as bifunctional catalysts, the assembled Ni2+xFe2−xN/NC||Ni2+xFe2−xN/NC electrolyzer only needs 1.51 V cell voltage for driving OWS to approach 10 mA cm–2 water‐splitting current, exceeding their counterparts and the‐state‐of‐art reported bifunctional catalysts‐based devices, and Pt/C||IrO2 couples. Additionally, the Ni2+xFe2−xN/NC||Ni2+xFe2−xN/NC manifests excellent durability for OWS. The findings presented here may spur the development of advanced TMNs nanostructures by combining phase, structure engineering, and hybridization strategies and stimulate their applications toward OWS or other clean energy fields.
Simulating the influence of Facebook fan pages on individual attitudes toward vaccination using agent‐based modelling
Authors: Al Atiqi Muhammad , Chang Shuang , Deguchi Hiroshi 
Published: August 2022

AbstractThe anti‐vaccination movement is dangerous because of its influence on vaccine hesitancy. Nowadays, social media platforms become significant sources of anti‐vaccination information; therefore, combating their proliferation needs to be addressed by the relevant authorities. Previous studies suggested two policies to mitigate the negative influence of anti‐vaccination information online: attaching caution banners from healthcare authorities and engaging in censorship of anti‐vaccine supporting information providers. However, these recommendations were obtained without considering how the users form their sentiments. In this paper, we explore the influence of the existing network of vaccination‐related Facebook pages on an individual user's vaccination sentiment using agent‐based modelling (ABM). We use the ABM implementation of the Zaller model to convert the user's information consumption to their vaccination sentiment. Our simulation results show that the application of the two policies leads to improved sentiment on vaccination, reinforcing existing suggestions obtained by different methods.
Demonstration of no catalytical activity of Fe‐N‐C and Nb‐N‐C electrocatalysts toward nitrogen reduction using in‐line quantification
Authors: Sveinbjörnsson Arnar , Gunnarsdóttir Anna Bergljót , Creel Erin B. , Canales Camila Pía , Zulevi Barr , Lyu Xiang , Jafta Charl J. , Skúlason Egill , Serov Alexey , Flosadóttir Helga Dögg 
Published: August 2022

AbstractAmmonia (NH3) production via the electrochemical nitrogen reduction reaction (NRR) is a promising method for sustainable generation of this important chemical. Efforts are ongoing in finding an efficient, stable, and selective catalyst that will enable the reaction. However, progress is hindered in the field due to lack of reproducibility, most likely a consequence of reports of false‐positive results due to improper measurement control and methods. In this study, we explore the NRR activity of a promising class of single atom catalysts, transition metal‐nitrogen‐carbon (M‐N‐C) electrocatalysts. Using a state‐of‐the‐art in‐line ammonia quantification methodology, with detection limit as low as 1 ppb for ammonia, we show that single atom Nb and Fe embedded in a stable carbon and nitrogen framework do not electrochemically reduce N2 to NH3. Critically, this demonstrates that our experimental setup with in‐line sequential injection analysis successfully excludes ammonia contamination from the gas supply and atmospheric sources, allowing for thorough and high‐throughput examination of potential NRR catalysts.
Correction of fetal umbilical vein flow imbalance following laser surgery for twin–twin transfusion syndrome
Authors: Saab R. H. , DeVore G. R. , Monson M. , Masri J. , Korst L. M. , Chmait R. H. 
Published: August 2022

ABSTRACTObjectivesTwin–twin transfusion syndrome (TTTS) is characterized by unequal hemodynamics between the twins. We aimed to assess preoperatively the difference in umbilical vein flow (UVF) between the recipient and donor monochorionic diamniotic twins and evaluate the change in UVF following laser surgery in both twins.MethodsThis was a retrospective cohort study of differences in UVF that occurred following laser surgical treatment of TTTS. Sonographic assessment of the umbilical vein before and 24 h after fetoscopic laser surgery for TTTS was performed. Umbilical vein diameter and time‐averaged maximum velocity were measured, and UVF per kg (UVF/kg) was converted into a Z‐score by a calculator created using gestational age as an independent variable. Z‐score values were converted into centiles, which were evaluated statistically. Median differences in UVF/kg centile values were adjusted for TTTS stage and presence of arterioarterial anastomoses.ResultsThe study population consisted of 363 TTTS patients. The adjusted preoperative median difference in UVF/kg centile between the recipient vs donor twin was 17.9% (−17.1% to 57.6%), P < 0.0001. The adjusted median difference in UVF/kg centile between the postoperative vs preoperative period among recipients was 2.2% (−10.8% to 13.8%), P < 0.0001, while the adjusted median difference among donors was 27.3% (8.2%–34.6%), P < 0.0001.ConclusionThe preoperative difference in UVF between the recipient and donor twins confirms the pathophysiology of TTTS. Postoperatively, the substantial increase in UVF of the donor twin and the relatively small increase in UVF of the recipient twin confirm that ablation of the vascular communications resulted in rapid improvement in perfusion of the donor twin. © 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Können Fahrassistenzsysteme zum Erhalt der Mobilität im Alter beitragen? Eine Betrachtung aus Perspektive der Mensch-Maschine Interaktion
Authors: Gärtner Magdalena , Braun Hanna , Meschtscherjakov Alexander 
Published: August 2022

ZusammenfassungAutofahrer*innen höheren Alters sind besonders gefährdet sich bei einem Verkehrsunfall schwer zu verletzen oder sogar tödlich zu verunglücken. Es ist daher ein Anliegen der Forschung, diese Risikogruppe im Straßenverkehr zu schützen und zu unterstützen. Auf die Bedürfnisse der Nutzer*innen abgestimmte Fahrassistenzsysteme können dabei eine entscheidende Rolle spielen.
A novel platform to enable the future human-centered factory
Authors: Generosi Andrea , Agostinelli Thomas , Ceccacci Silvia , Mengoni Maura 
Published: August 2022

AbstractThis paper introduces a web-platform system that performs semi-automatic compute of several risk indexes, based on the considered evaluation method (e.g., RULA—Rapid Upper Limb Assessment, REBA—Rapid Entire Body Assessment, OCRA—OCcupational Repetitive Action) to support ergonomics risk estimation, and provides augmented analytics to proactively improve ergonomic risk monitoring based on the characteristics of workers (e.g., age, gender), working tasks, and environment. It implements a body detection system, marker-less and low cost, based on the use of RGB cameras, which exploits the open-source deep learning model CMU (Carnegie Mellon University), from the tf-pose-estimation project, assuring worker privacy and data protection, which has been already successfully assessed in standard laboratory conditions. The paper provides a full description of the proposed platform and reports the results of validation in a real industrial case study regarding a washing machine assembly line composed by 5 workstations. A total of 15 workers have been involved. Results suggest how the proposed system is able to significantly speed up the ergonomic assessment and to predict angles and perform a RULA and OCRA analysis, with an accuracy comparable to that obtainable from a manual analysis, even under the unpredictable conditions that can be found in a real working environment.
Quantification of cortisol and its metabolites in human urine by LC-MSn: applications in clinical diagnosis and anti-doping control
Authors: Arioli Francesco , Gamberini Maria Cristina , Pavlovic Radmila , Di Cesare Federica , Draghi Susanna , Bussei Giulia , Mungiguerra Francesca , Casati Alessio , Fidani Marco 
Published: August 2022

Abstract
The objective of the current research was to develop a liquid chromatography-MSn (LC-MSn) methodology for the determination of free cortisol and its 15 endogenous metabolites (6β-hydroxycortisol, 20α-dihydrocortisol, 20α-dihydrocortisone, 20-β-dihydrocortisol, 20β-dihydrocortisone, prednisolone, cortisone, α-cortolone, β-cortolone, allotetrahydrocortisol, 5α-dihydrocortisol, tetrahydrocortisol, allotetrahydrocortisone, 5β-dihydrocortisol, tetrahydrocortisone) in human urine. Due to its optimal performance, a linear ion trap operating in ESI negative ion mode was chosen for the spectrometric analysis, performing MS3 and MS4 experiments. The method was validated for limit of detection (LOD) and limit of quantification (LOQ) (0.01 ng mL−1 and 0.05 ng mL−1, for all compounds, respectively), intra- and inter-day precision (CV = 1.4–9.2% and CV = 3.6–10.4%, respectively), intra- and inter-day accuracy (95–110%), extraction recovery (65–95%), linearity (R2 > 0.995), and matrix effect that was absent for all molecules. Additionally, for each compound, the percentage of glucuronated conjugates was estimated. The method was successfully applied to the urine (2 mL) of 50 healthy subjects (25 males, 25 females). It was also successfully employed on urine samples of two patients with Cushing syndrome and one with Addison’s disease. This analytical approach could be more appropriate than commonly used determination of urinary free cortisol collected in 24-h urine. The possibility of considering the differences and relationship between cortisol and its metabolites allows analytical problems related to quantitative analysis of cortisol alone to be overcome. Furthermore, the developed method has been demonstrated as efficient for antidoping control regarding the potential abuse of corticosteroids, which could interfere with the cortisol metabolism, due to negative feedback on the hypothalamus-hypophysis-adrenal axis. Lastly, this method was found to be suitable for the follow-up of prednisolone that was particularly important considering its pseudo-endogenous origin and correlation with cortisol metabolism.
Graphical abstract
Extreme rainfall in Northern China in September 2021 tied to air–sea multi-factors
Authors: Sun Yue , Li Jianping , Wang Hao , Li Ruize , Tang Xinxin 
Published: August 2022

AbstractThe September rainfall over Northern China (NC) in 2021 was the heaviest since 1961 and had unprecedented socioeconomic impacts. Holding the hypothesis that the drivers of extreme climate events usually contain extreme factors, we firstly propose the Ranking Attribution Method (RAM) to find the possible air–sea multi-factors responsible for this rainfall event. Via the atmospheric bridges of zonal-vertical circulation and Rossby wave energy propagation, the remote factors of warm sea surface temperature anomalies (SSTA) over the tropical Atlantic, cold SSTA over the tropical Pacific, Southern Annular Mode-like pattern in the Southern Hemisphere and North Pacific Oscillation-like pattern in the Northern Hemisphere jointly strengthened the Maritime Continent (MC) convection and Indian monsoon (IM). Through meridional-vertical circulation, the intensified MC convection enhanced the subtropical high over southern China and induced ascending motion over NC. The local factor of extreme air acceleration in the east Asian upper-level jet entrance region further anchored the location of the southwest-northeast rain belt. The strengthened IM and subtropical high over southern China induced considerable moisture transport to the rain belt via two moisture channels. The combined effect of these extreme dynamic and moisture conditions formed this unprecedented rainfall event. This study suggests that the RAM can effectively reveal the factors that contributed to this extreme rainfall event, which could provide a new pathway for a better understanding of extreme climate events.
PerformERL: a performance testing framework for erlang
Authors: Cazzola Walter , Cesarini Francesco , Tansini Luca 
Published: August 2022

AbstractThe Erlang programming language is used to build concurrent, distributed, scalable and resilient systems. Every component of these systems has to be thoroughly tested not only for correctness, but also for performance. Performance analysis tools in the Erlang ecosystem, however, do not provide a sufficient level of automation and insight needed to be integrated in modern tool chains. In this paper, we present : an extendable performance testing framework that combines the repeatability of load testing tools with the details on how the resources are internally used typical of the performance monitoring tools. These features allow to be integrated in the early stages of testing pipelines, providing users with a systematic approach to identifying performance issues. This paper introduces the framework, focusing on its features, design and imposed monitoring overhead measured through both theoretical estimates and trial runs on systems in production. The uniqueness of the features offered by , together with its usability and contained overhead prove that the framework can be a valuable resource in the development and maintenance of Erlang applications.
Developing a trigger tool to monitor adverse events during haemodialysis in children: a pilot project
Authors: Balasubramanian Ramnath , Folwell Rachel , Wheatley Arran , Ramsey Heidi , Barton Carmen , Reid Christopher J. D. , Sinha Manish D. 
Published: August 2022

Abstract

Background
We developed a paediatric haemodialysis trigger tool (pHTT) for application per haemodialysis (HD) session in children receiving intermittent in-centre HD and systematically monitored adverse events.

Methods
Single-centre quality improvement study performed over two 8-week cycles. Data collected prospectively using a ‘per-dialysis session’ pHTT tool including 54 triggers across six domains, adapted from a recently described haemodialysis trigger tool (HTT) for adults. Each trigger was evaluated for level of harm following assessment by two authors. Following a period of training, HD nurses completed the HTT at the end of each dialysis session.

Results
There were 241 triggers over 182 dialysis sessions, with 139 triggers in 91 HD sessions for 15 children, age range 28–205 months, over an 8-week period (first cycle) and 102 triggers in 91 HD sessions for 13 children, age range 28–205 months, over a further 8-week period (second cycle). After interventions informed by the pHTT, the harm rate per session was significantly reduced from 1.03 (94/91) to 0.32 (29/91), P < 0.001. There was a significant difference between the distribution of triggers by harm category (P < 0.001) and between the proportion of triggers across the various domains of the pHTT (P = 0.004) between the two cycles. No triggers were evaluated as causing permanent harm.

Conclusions
This pilot study demonstrates potential benefits of a bedside tool to monitor adverse events during haemodialysis in children. Thus, following interventions informed by the pHTT, the harm rate per session was significantly reduced. Under standard patient safety systems, the vast majority of triggers identified by the pHTT would remain unreported and perhaps lead to missed opportunities to improve patient safety. We propose the use of a paediatric HTT as part of standard care by centres providing HD to children in the future.

Graphical Abstract
A higher resolution version of the Graphical abstract is available as Supplementary information
Intraabdominal sporadic desmoid tumors and inflammation: an updated literature review and presentation and insights on pathogenesis of synchronous sporadic mesenteric desmoid tumors occurring after surgery for necrotizing pancreatitis
Authors: Prete Francesco , Rotelli MariaTeresa , Stella Alessandro , Calculli Giovanna , Sgaramella Lucia Ilaria , Amati Antonio , Resta Nicoletta , Testini Mario , Gurrado Angela 
Published: August 2022

AbstractSporadic intra-abdominal desmoid tumors are rare and known to potentially occur after trauma including previous surgery, although knowledge of the underlying pathogenetic mechanism is still limited. We reviewed the recent literature on sporadic intraabdominal desmoids and inflammation as we investigated the mutational and epigenetic makeup of a case of multiple synchronous mesenterial desmoids occurring after necrotizing pancreatitis. A 62-year-old man had four mesenteric masses up to 4.8 cm diameter detected on CT eighteen months after laparotomy for peripancreatic collections from necrotizing pancreatitis. All tumors were excised and diagnosed as mesenteric desmoids. DNA from peripheral blood was tested for a multigene panel. The tumour DNA was screened for three most frequent β-catenin gene mutations T41A, S45F and S45P. Expression levels of miR-21-3p and miR-197-3-p were compared between the desmoid tumors and other wild-type sporadic desmoids. The T41A CTNNB1 mutation was present in all four desmoid tumors. miR-21-3p and miR-197-3p were respectively upregulated and down-regulated in the mutated sporadic mesenteric desmoids, with respect to wild-type lesions. The patient is free from recurrence 34 months post-surgery. The literature review did not show similar studies. To our knowledge, this is the first study to interrogate genetic and epigenetic signature of multiple intraabdominal desmoids to investigate potential association with abdominal inflammation following surgery for necrotizing pancreatitis. We found mutational and epigenetic features that hint at potential activation of inflammation pathways within the desmoid tumor.
The histone deacetylase SIRT6 promotes glycolysis through the HIF-1α/HK2 signaling axis and induces erlotinib resistance in non-small cell lung cancer
Authors: You Qiai , Wang Jianmin , Yu Yongxin , Li Feng , Meng Lingxin , Chen Mingjing , Yang Qiao , Xu Zihan , Sun Jianguo , Zhuo Wenlei , Chen Zhengtang 
Published: August 2022

AbstractErlotinib is a first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Overcoming erlotinib resistance is crucial to improve the survival of advanced non-small cell lung cancer (NSCLC) patients with sensitive EGFR mutations. It is also an important clinical problem that urgently needs a solution. In this study, we explored strategies to overcome erlotinib resistance from the perspective of energy metabolism. SIRT6 is a histone deacetylase. Here, we found that high expression of SIRT6 is associated with poor prognosis of lung adenocarcinoma, especially in EGFR-mutated NSCLC patients. The next cell experiment found that SIRT6 expression increased in erlotinib-resistant cells, and SIRT6 expression was negatively correlated with the sensitivity of NSCLC to erlotinib. Inhibition of SIRT6 promoted erlotinib-induced apoptosis in erlotinib-resistant cells, and glycolysis in drug-resistant cells was also inhibited. Functional studies have shown that SIRT6 increases glycolysis through the HIF-1α/HK2 signaling axis in drug-resistant cells and inhibits the sensitivity of NSCLC cells to erlotinib. In addition, the HIF-1α blocker PX478-2HCL attenuated the glycolysis and erlotinib resistance induced by SIRT6. More importantly, we confirmed the antitumor effect of SIRT6 inhibition combined with erlotinib in NSCLC-bearing mice. Our findings indicate that the cancer metabolic pathway regulated by SIRT6 may be a new target for attenuating NSCLC erlotinib resistance and has potential as a biomarker or therapeutic target to improve outcomes in NSCLC patients.