bluuebunny/crossref_metadata_2025_split huggingface dataset:
CURRENT STATE OF RESEARCH IN THE FIELD OF CHEMICAL COMPOSITION AND PHARMACOLOGICAL EFFECTS OF ZEA MAYDIS STYLI CUM STIGMATIS
Authors: Nikiforova E. B. , Bat N. M. , Davitavyan N. A. 
Published: March 2022

Zea maydis styli cum stigmatis (Engl. corn silk) are well known in medical practice. In the scientific literature, a lot of information has been accumulated about the chemical composition and pharmacotherapeutic actions of this medicinal plant material. A chronological analysis of this information shows that earlier, the scope of scientific publications was mainly devoted to the study of the choleretic, diuretic, hemostatic kinds of Zea maydis styli cum stigmatis activity, and the identification of the active substances responsible for these types of action. Currently, there is a growing scientific interest not only in the individual natural compounds of the Zea maydis styli cum stigmatis composition, but also in the search for new aspects of their medical application.The aim of the article is a review and systematization of modern scientific data in the field of the Zea maydis styli cum stigmatis chemical composition and their pharmacological action.Materials and methods. For the information and analytical search, the scientific data posted on the following electronic resources were used: PubMed, Web of Science, ScienceDirect, Scopus, Google Scholar, eLibrary. The search was carried out in the period from 2005 to 2021 using the following keywords: Zea mays L.; Zea maydis styli cum stigmatis; corn silk; chemical composition; pharmacological action.Results. The review is devoted to the generalization and analysis of modern scientific data on the Zea maydis styli cum stigmatis chemical composition and their pharmacological action. It has been shown that, as before, the greatest attention of scientists is attracted by flavonoids in the Zea maydis styli cum stigmatis chemical composition. Alongside with them, phenolcarboxylic acids, vitamin K, phytosterols, volatile compounds and polysaccharides are of no small importance for the Zea maydis styli cum stigmatis pharmacological activity. Modern ideas about the Zea maydis styli cum stigmatis pharmacological activity have been expanded by summarizing the study results of their antioxidant, anti-inflammatory, antidiabetic, hypotensive, neuro- and photoprotective activities. The data on the effectiveness of their use as parts of the complex tumor diseases therapy have been published.Conclusion. As a result of the data analysis of modern scientific literature, it has been found out that Zea maydis styli cum stigmatis are still in the sphere of scientists’ interest. Alongside with the flavonoids of this raw material, other groups of pharmacologically active substances are also being actively studied. It has been revealed that the information about potentially significant and confirmed types of the Zea maydis styli cum stigmatis therapeutic action is significantly updated. The results of this review may be useful for identifying promising directions for the development of the drugs based on Zea maydis styli cum stigmatis.
DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS
Authors: Elagina A. O. , Belyatskaya A. V. , Krasnyuk (Jr.) I. I. , Krasnyuk I. I. , Stepanova O. I. , Fateeva T. V. , Smolyarchuk E. A. , Kozin S. V. , Plakhotnaya O. N. , Rаstopchina O. V. , Rau J. V. 
Published: March 2022

Taking into account the current Product specification file, the aim of the work was to develop the composition and technology for obtaining effervescent tablets based on solid dispersions of furazolidone in the form of an aqueous solution for external use.Materials and methods. The used substances were: furazolidone, anhydrous sodium carbonate (chemically pure), polyvinylpyrrolidone-24000±2000 (chemically pure), malic acid (analytically pure), tartaric acid (chemically pure), citric acid (chemically pure), sodium benzoate (chemically pure), ethyl alcohol 96% (chemically pure), purified water. Preparation of granulates is separate wet granulation in a fluidized bed (Mycrolab, BOSCH, Germany). Obtaining tablets is the process of pressing on a manual hydraulic test press (“PRG”, VNIR, Russia). The dependence of disintegration, abrasion capacity and crushing resistance on compacting pressure was investigated. Technological parameters of granulates, еру obtained effervescent tablets, shelf life and storage conditions were investigated according to the State Pharmacopoeia of the Russian Federation XIVth ed.Results. Two compositions of effervescent tablets containing solid dispersions of furazolidone as an active substance were obtained, which, when dissolved in 100 ml of water at room temperature (20°C), form a solution of furazolidone with a concentration of 0.004% in less than 5 minutes. The method of quantitative determination of the furazolidone content in the effervescent tablets was validated. A complex of physicochemical methods for the analysis of tablets was carried out. Quality standards have been developed. The developed compositions stability of instant tablets during storage during accelerated and long-term tests has been experimentally confirmed. The preliminary shelf life and storage conditions have been determined.Conclusion. The result of technological and chemical-pharmaceutical research is the creation and evaluation of the quality of a new instant furazolidone dosage form as effervescent tablet formulations.
Spectrofluorometric analysis to trace the molecular fingerprint of wine during the winemaking process and recognise the blending percentage of different varietal wines
Authors: Ranaweera Ranaweera K.R. , Gilmore Adam M. , Bastian Susan E.P. , Capone Dimitra L. , Jeffery David W. 
Published: March 2022

As a robust analytical method, spectrofluorometric analysis with machine learning modelling has recently been used to authenticate wine from different regions, vintages and varieties. This preliminary study investigated whether the molecular fingerprint obtained with this approach is maintained throughout the winemaking process, along with assessing different percentages of wine in a blend. Monovarietal wine samples were collected at different stages of the winemaking process and analysed with the absorbance-transmission and fluorescence excitation-emission matrix (A-TEEM) technique. Wines were clustered tightly according to origin for the different winemaking stages, with some clear separation of different regions and varieties based on principal component analysis. In addition, wines were classified with 100 % accuracy according to varietal origin using extreme gradient boosting (XGB) discriminant analysis. The sensitivity of the A-TEEM technique was such that it allowed for accurate modelling of wine blends containing as little as 1 % of Cabernet-Sauvignon or Grenache in Shiraz wine when employing XGB regression, which performed better than partial least squares regression. The overall results indicated the potential for applying A-TEEM and machine learning modelling to wine chemical traceability through production to guarantee the provenance of wine or identify the composition of a blend.
KOMUNIKASI PEMASARAN MERUPAKAN LIVE BRIDGING PADA ERA PANDEMI 2020-2021
Authors: Kinkin Yuliaty Subarsa Putri  , Rayni Delya Hafni  , Risma Hasna Dwiwina  , Yesi Andriani  , Kiki Dwi Arviani  
Published: March 2022

Abstract
The Covid-19 pandemic in Indonesia disrupted people's livelihoods, both in terms of economic conditions and activities, so that the community's financial sector came to a halt. However, at the end of 2020, economic conditions flared up again. The formulation of the problem in this study is how marketing communication is live bridging in the 2020-2021 pandemic era. The purpose of this study is to determine marketing communication which is live bridging in the 2020-2021 pandemic era. In this study, researchers used quantitative research methods by distributing questionnaires with correlation analysis. This research's results are descriptive; namely, the correlation is positive in marketing communication and community attitudes. In simple regression analysis, there is a strong influence between marketing communication on people's attitudes. Marketing communication theory strongly influences all dimensions of public attitudes, both cognitively, affective, and conative—further research by being developed in collaboration with other scientific studies and using different methods.
Keywords: marketing communication, elaborative research, forecasting research
Abstrak
Pandemi Covid-19 di Indonesia membuat kehidupan bermasyarakat menjadi terganggu, baik dari segi kondisi ekonomi dan aktivitasnya sehingga membuat sektor perekonomian masyarakat menjadi terhenti. Namun, pada akhir tahun 2020 kondisi perekonomian bergejolak kembali. Adapun rumusan masalah dalam penelitian ini adalah bagaimana komunikasi pemasaran merupakan live bridging pada era pandemic 2020-2021 sehingga tujuan penelitian ini untuk mengetahui komunikasi pemasaran yang merupakan live bridging pada era pandemik 2020-2021. Dalam penelitian ini, digunakan metode penelitian kuantitatif, dengan cara menyebarkan kuesioner dengan analisis korelasi. Hasil dari penelitian ini secara deskriptif yaitu korelasinya bernilai positif pada komunikasi pemasaran dan sikap masyarakat, sedangkan pada analisis regresi sederhana terdapat suatu pengaruh yang kuat antara komunikasi pemasaran terhadap sikap masyarakat. Teori komunikasi pemasaran pada semua dimensinya berpengaruh kuat terhadap semua dimensi sikap masyarakat baik secara kognitif, afektif dan konatif sehingga hasil penelitian ini dapat dikembangkan ke arah penelitian selanjutnya dengan dikembangkan dengan berkolaborasi pada kajian ilmu pengetahuan dan menggunakan metode lainnya.
Kata Kunci: komunikasi pemasaran, penelitian elaboratif, penelitian perkiraan
Conceptualizing Biological Aging and Frailty in Orthopaedics
Authors: Cong Ting , Hall Arielle J. , Jia Zhimeng , Christiano Anthony , Elsevier Hannah C.K. , Cheung Zoe B. , Wellman David , Forsh David , Lane Joseph M. 
Published: March 2022

➤ Biological aging can best be conceptualized clinically as a combination of 3 components: frailty, comorbidity, and disability.➤ Despite advancements in the understanding of senescence, chronological age remains the best estimate of biological age. However, a useful exercise for practitioners is to look beyond chronological age in clinical and surgical decision-making.➤ A chronologically aging person does not age biologically at the same rate.➤ The best way to understand frailty is to consider it as a physical phenotype.➤ Physical optimization should parallel medical optimization before elective surgery.➤ The poorer the host (both in terms of bone quality and propensity for healing), the more robust the implant construct must be to minimize reliance on host biology.
Seawater Intrusion-Retreat Processes and Groundwater Evolution in Intruded Coastal Aquifers with Land Reclamation: A Case Study of Eastern Jiangsu, China
Authors: Xiong Guiyao , Chen Guangquan , Wu Jichun , Fu Tengfei , Yang Yun , Xu Xingyong , Zhu Xiaobin , Yu Hongjun , Liu Shengfa , Gao Maosheng , Hou Guohua 
Published: March 2022

Abstract
The hydrogeochemical analysis and numerical simulation were conducted to explore the impact of land reclamation on submarine groundwater discharge and groundwater evolution in the seawater intrusion-retreat processes in eastern Jiangsu, China. The hydrogeochemical results indicated that the origin of salt in most groundwater is saltwater mixing, and weathering-dissolution of minerals enriches the salt in fresh groundwater. The evolution path of coastal groundwater in Jiangsu is Ca-Na-HCO3-Cl → Ca-Na-Cl-HCO3 → Na-Ca-Cl-HCO3 → Na-Mg-HCO3 → Na-Mg-HCO3-Cl → Na-Cl-HCO3 → Na-Cl, and the difference in groundwater evolution in different regions is obvious. The numerical simulation revealed that the land reclamation has blocked groundwater exchange and restrained the seawater intrusion. The sensitive analysis indicated that the permeability and the slope of the land reclamation have dominated the salinity distribution. And the aquifer heterogeneity promotes groundwater evolution and leads to the irregular salinity distribution of the groundwater. Moreover, the groundwater evolution in the shallow aquifer with the land reclamation shows that the residual seawater is gradually desalinating and discharged into the sea. The land reclamation is salinized by saltwater discharge and seawater intrusion together and then subsides into a stable saltwater wedge. The groundwater salinity distribution in Jiangsu is not fit seawater intrusion, which is caused by the coastline changes due to anthropogenic land reclamation and natural activities.
Experimental Study on Physical and Mechanical Properties of Beishan Granite after Cyclic Heating and Cooling with Water
Authors: Wang Z. H. , Guo L. , Li S. M. , Konietzky Heinz 
Published: March 2022

Abstract
Granite characterized by low permeability and high strength is commonly seen in underground construction. This paper is aiming at studying the influence of cyclic heating and water cooling on physicomechanical properties of Beishan granite, which is chosen as a potential host surrounding rock of a high level nuclear waste (HLW) repository. In this study, physical and mechanical properties of Beishan granite after repeated heating-cooling cycles are described. After five heating-cooling cycles with temperature up to 300°C, the diameter and length of specimens increase by 0.090% and 0.052%, respectively. And the mass of specimen reduces by 0.32 g. In the following conventional triaxial compression (CTC) tests, the peak strength shows a slightly increase, but the dilatancy threshold decreases. And both peak strain and dilatancy threshold strain exhibit increase, which is responsible for the decrease of Young’s modulus. During the test, acoustic emission (AE) is rarely monitored in the early loading and starts to generate systematically when the axial stress is beyond dilatancy threshold. On the other hand, in the hydraulic (HM) coupled experiments, both peak strength and dilatancy threshold show decrease. However, the ratio between dilatancy threshold and peak strength shows slightly increase. The same phenomenon can be observed for the peak strength and dilatancy threshold. The permeability shows rarely change compared with that of the specimen without experienced cyclic heating-cooling. AE is significantly monitored in the initial loading, which is seem more than that generated from dilatancy threshold to peak strength. The obtained results are useful for the construction of HLW repository.
Nanoparticle Assisted Foam Stability Under SAGD Conditions
Authors: Maaref Sepideh , Kantzas Apostolos 
Published: March 2022

Abstract
Thermal oil recovery processes, and more specifically steam assisted gravity drainage (SAGD), is one of the two commercial methods to produce heavy oil. In the later stages of SAGD heat losses increase. One solution to improve heat losses in the steam chamber is to co-inject a foaming solution with non-condensable gases. It is expected that such a scheme will redirect steam towards heating oil and not the overburden. An appropriate foaming agent is required for successful implementation of a steam-foam process. Conventional laboratory techniques have provided some indication of foam stability with different types of surfactants but failed to match the reservoir conditions and time scale. Recently, the use of nanoparticles along with surfactants has gained attention as a method to stabilize foams under thermal operating conditions. The aim of this research is to investigate the thermal stability of foam under steam conditions (temperatures around 200 °C) using mixtures of different surfactants and silica nanoparticles. A series of foam stability tests were conducted at temperature ranges of 170 °C to 212 °C and pressures of 2.78 MPag and 4.22 MPag using two different anionic surfactants and four different bare and coated silica nanoparticles. The foamy solutions were prepared with a combination of different surfactants and nanoparticles, which were co-injected with N2 gas into a sand pack to generate foam at different temperatures and pressures. The generated foam was then transferred to a high pressure and high temperature visual cell and the foam half-life was measured as the indicator of its decay.
It was observed that a small deviation from the dew point (decreasing the temperature or increasing the pressure) significantly improved foam stability. Addition of nanoparticles proved to be synergistic as the foam half-life near the steam dew point increased about four-fold compared to surfactant only foams. Among the tested nanoparticles, the use of polyethylene glycol (PEG) coated silica nanoparticles along with an anionic surfactant resulted in the highest foam stability near the steam dew point.
To date, most of the foam stability tests have been conducted at temperatures below 200 °C with the focus on using surfactants. This research extended the foam stability tests to temperatures in excess of 200°C using mixtures of surfactants and nanoparticles. Although the foam stability still needs to be improved for reservoir-scale application, our screening methodology presents a realistic process of generating foam in a porous medium with nanoparticles and surfactants under a desired thermodynamic state for subsequent foam thermal stability testing.
Enhancing Reservoir Engineering Workflows with Augmented and Virtual Reality
Authors: Cartwright Stephen , Samoil Steven , Lawton Bryson , Hu Die , Xie Siqi , Wang Eric , Aminbeidokhti Amir , Dawar Seher , Dalton Rachel , Daeijavad Parisa , Maurer Frank , Chen Zhangxin 
Published: March 2022

AbstractReservoir engineers must analyze and work with complicated 3D subsurface datasets. Extended reality (XR) hardware has undergone a renaissance in recent years and high-quality hardware is now widely available and affordable. What remains unsolved is how these technologies may be applied to improve reservoir engineering workflows, in order to help plan scenarios that reduce emissions and improve project efficiencies. We detail and discuss the first-year outcomes of an industry-academia collaboration which explores the application of XR technologies to a reservoir engineering workflow.A thorough review of the benefits of XR technology compared with conventional display and input devices was performed. The results of this were used to inform the design and development of a proof-of-concept visualization and analysis application for reservoir engineering workflows that utilizes the strengths of XR technology. Using this tool, representations of numerical reservoir models can be visualized and analyzed along with other data within virtual working spaces. User-driven interactions were designed for this application and implemented to be as intuitive and effective as possible. Networking capabilities were implemented so that multiple devices and multiple users may access any given virtual workspace, supporting both remote collaboration and cross-reality functionality. The features and design of the application were all developed with the intention of directly supporting the visualization and analysis of reservoir data.The benefits provided by utilizing XR technology include increased working space, improved spatial perception, and more intuitive user interaction. Features such as multi-model visualization, integration of 2D information visualization, data analysis features, and several different filtering techniques were developed to further enhance reservoir engineering workflows. Additional features in development that are highly anticipated by our industrial partner include methods to better facilitate clear communication when working with data in groups, the integration of presentation and group-work modes, and enhancing workflows with AI-assisted tasks. Careful consideration went into designing interactions that were natural and intuitive, yet flexible and efficient when working within 3D virtual environments.The innovation demonstrated in this project contributes to advancing the Canadian energy industry to a new era of exciting new visual and interactive technologies, while ensuring that these technologies can be utilized to provide true value to real-world problems. The lessons learned and design insights gained from this project may be applied far beyond reservoir engineering to enhance workflows in any domain where analysis of complex scientific datasets is required.
Consideration of Various Parameters and Scenarios in the Simulation of Hydrate Formation
Authors: Sahari Moghaddam Farzan , Hamid Ali , Abdi Majid , James Lesley 
Published: March 2022

Abstract
This study investigates the effect of various parameters on hydrate formation under two scenarios of regular and cold start-up operations in a flowline and a subsea network. Parameters including hydrate adhesion forces, required subcooling for hydrate nucleation, and a weighting parameter for hydrate-oil slip (COIL) are evaluated. The effect of methanol injection and the mentioned parameters on hydrate formation are compared to 0.2 hydrate fraction threshold from literature.
Hydrate formation from oil having 184 m3/m3 GOR and 35% WC is studied using two scenarios of regular and cold start-up operations in a 6-km flowline and a subsea tieback network (consisting of two branches and a main flowline). The overall heat transfer coefficient is 22.7 W/(m2.K), and the simulation is conducted by OLGA-CSMHyK-MUTIFLASH. Slurry relative viscosity, hydrate fraction, and hydrate propensity in terms of temperature difference known as DTHYD are used as indicators, and a hydrate fraction threshold of 0.2 is considered. Adhesion forces (0.5 - 0.005 N/m), required subcooling (3.61 - 10 °C), COIL (0.2-1), and methanol injection are investigated.
During regular operation, the flow pattern remains stratified in a single flowline having 35% WC and 1 COIL. By increasing the required subcooling for hydrate nucleation from 3.6 °C to 10 °C, the hydrate fraction was reduced from approximately 1.7% to zero. COIL has the greatest effect on hydrate fraction. The reduction of adhesion forces had a noticeable effect on oil viscosity compared to the other indicators. Plug formation is not expected in the studied single flowline and subsea network under normal operation. On the other hand, a potential plug based on higher hydrate formation occurs in a cold start-up operation even under the effect of the studied parameters. However, the chance of plug formation is considerably reduced by injecting 20 wt% methanol. Overall, assessing the three indicators of hydrate formation (slurry relative viscosity, hydrate fraction, and DTHYD) are critical and provide more realistic insight about hydrate formation compared to using only one of the indicators for the evaluations.
This work investigates the three aforementioned indicators of hydrate formation rather than relying on only one indicator (e.g., hydrate fraction) under regular and cold restart operations. The study evaluates hydrate formation based on a hydrate fraction threshold of 0.2 for a potential plug, compared to thermodynamically preventing hydrate formation.