bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of lignin and released acid on the gelation and aerogel fabrication of whole biomass in the lithium bromide molten salt hydrate system
Authors: Guo Xu , Cao Xinyu , Xiao Tianyuan , Hou Minjie , Li Changgeng , Sheng Xueru , Guo Yanzhu , Sun Yanning , Fatehi Pedram , Shi Haiqiang 
Published: November 2022

Abstract
Biomass-based aerogels have received attention these days due to their environmentally friendly and easily degradable nature. However, the aerogel production is challenged by the generation of acid in aerogel manufacturing. This work aims at understanding how acid originating from biomass would impact aerogel production. In this study, alkali pre-extraction (APE) was carried out to demonstrate how the acidic substances released from poplar in a green inorganic molten salt hydrate solvent (LiBr·3H2O) would impact the properties of biomass-based aerogels. To understand the impact of lignin on aerogel production, the aerogel production was carried out on lignin-free biomass. The results confirmed that alkali pretreatment of biomass could be an effective method to accelerate the production of biomass-based aerogels. The biomass and particle size primarily affected the properties and microstructure of aerogels. Also, lignin has a substantial adverse effect on such aerogel production. Therefore, selecting suitable alkali treatment conditions, biomass content and particle size have crucial effects on the preparation of lignin-containing aerogels and lignin-free aerogels.
Bis(oxime Palladacyle) Supported on Magnetized SBA-15 as an Efficient and Retriveble Catalyst for the Mizoroki-Heck Reaction
Authors: Ghahremani Fateme , Mansoori Yagoub , Bezaatpour Abolfazl , Esqu Dolores , Navarro M. Angeles 
Published: November 2022

Abstract
Herein, we report the anchoring of a bis(oxime palladacyle) adduct on magnetic mesoporous silica (Fe3O4@SBA-15). Magnetic mesoporous silica was successively treated with (3-aminopropyl) triethoxysilane (APTES), cyanuric chloride (CC), and 4-hydroxyacetophenone oxime-derived palladacycle to give Fe3O4@SBA-AP-CC-bis(oxime palladacycle). The resulting supported complex was characterized by analytical and spectroscopic techniques (FT-IR and CP/MAS 13C NMR). X‐Ray photoelectron spectroscopy (XPS) analysis corroborated the (+2) oxidation number for palladium. The catalytic potential of Fe3O4@SBA-AP-CC-bis(oxime palladacycle) was explored in the Mizoroki-Heck reaction. The effects of different reaction conditions, including the solvent, the base, temperature, and palladium content, were studied in detail. The catalyst shows a wide substrate scope, including aryl halides (I, Br, Cl) and olefins, in the Mizoroki-Heck reaction, using low catalyst loadings viz., Pd 0.09 mol%. The bis(oxime palladacyle) enjoys easy magnetic separation, stability, and recyclability over five runs.
Histopathology of the digestive gland of the snail Cantareus aspersus exposed chronically to cadmium and copper fungicide
Authors: Farfar Khadidja , Bouraiou Chiraz , Youbi Amira , Fetnaci Imene , Khebbeb Mohamed Elhadi , Djebar Mohamed Reda , Bouslama Zihad 
Published: November 2022

Abstract

The presence of unnatural substances in the environment increases in proportion to their use by humans. Thus, the development of agriculture will most certainly result in an increase in the concentration of pesticides and chemicals in the air, water and soil. They will therefore be able to reach ecosystems. In this study, we are interested in the histological effects of a copper-based fungicide Vacomil-Plus (2 g/l), cadmium (800 µg/l) and their mixture (CdCl2 + Copper fungicide, 1/1, V/V) on the digestive gland of bio-accumulators and bio-indicators of pollution: the snail Cantareus aspersus. We have chosen three processing times: Acute (15 days), sub-acute (30 days) and chronic (90 days). After each period, an individual chosen randomly from each batch, is shelled and then dissected to collect the target organ (digestive gland). The histological aspect of the digestive gland of treated snails illustrated tissue damages and alterations after exposure to cadmium, copper fungicide and their mixture, manifested by cellular hypertrophy, decreased epithelial height accompanied by chorion fibrosis confirming the toxicity of these two substances. In the other hand, we noted the appearance of nuclear pyknosis, necrosis and cellular apoptosis to treaties by the mixture (from 30 days of treatment) earlier that cadmium or copper fungicide single (90 days). Moreover, this study revealed that the cocktail was much more toxic to the tested snail than the Cadmium or the fungicide alone, therefore the cadmium have a synergic effect on this copper fungicide.
A picogram BA-ELISA quantification assay for rLj-RGD3, a platelet fibrinogen receptor antagonist, in the rat plasma and its application to a pharmacokinetic study
Authors: Wang Yuping , Liu Zhien , Han Guozhu , Yu Ping , Yang Xiaobo , Wang Jihong , Lv Li 
Published: November 2022

Abstract
Background: rLj-RGD3, a new member of RGD-motif toxin protein family derived from Lampetra japonica by means of DNA recombinant technique, has been demonstrated to be a platelet fibrinogen receptor antagonist. Researches over the years have shown that rLj-RGD3 has great value in developing as a useful antithrombotic and antitumor agent. Therefore, the study of pharmacokinetics is essential, so its quantification in plasma becomes a prerequisite. The present article aims to report a validated highly sensitive and specific double sandwich biotin-avidin enzyme linked immunosorbent assay (BA-ELISA) in order to provide a bio-analytical method for its pharmacokinetic (PK) study.
Results: The concentration of rLj-RGD3 in rat plasma was measured at a picogram level by the developed BA-ELISA method, which used two different mouse anti-rLj-RGD3 monoclonal antibodies as capture antibody and detection antibody, respectively, directed at different epitopes. The method was validated to be highly specific (no interference with the detection from blank plasma), precise (within day and between day RSD <10%) and accurate (94%-104%). The absolute recovery was as high as 94%-105%. The calibration curve showed good linearity ranging from 50 to 1600 pg/mL with regression equation of Y = 0.0011X + 0.0328 (r2 = 0.9981), the LOQ was found to be as low as 50 pg/mL. The above validated assay was successfully employed for the assessment of PK disposition of rLj-RGD3 in rats. After i.v. and s.c. dosing 30 µg/kg the rLj-RGD3 plasma concentration declined biexponentially with time, which could be best fitted by the two-compartment model. The drug PK behavior could be characterized by rapid elimination, extensive metabolism and low s.c. bioavailability.
Conclusions: The BA-ELISA method reported here was proved to completely meet requirements for PK study of rLj-RGD3, a toxin protein with effective pharmacological dose at µg/kg BW level.
Incidence and predictors of febrile neutropenia in patients with metastatic castrate- resistant prostate cancer receiving docetaxel
Authors: Peltekian Sophie , Sajwani Shellyza , Wang Xiang , Kanji Salmaan 
Published: November 2022

Abstract
Purpose
The incidence of febrile neutropenia (FN) in adults with castrate-resistant metastatic prostate cancer (mCRPC) receiving docetaxel in real-world settings since the expanded role of hormonal treatments has not been well studied. The study objective is to determine the incidence of FN and neutropenia among adults with mCRPC receiving docetaxel. Secondary objectives are to quantify outcomes of patients who develop FN and to identify predictors for FN in this population.
Methods
A single-centre retrospective cohort study was conducted which included adults with mCRPC receiving docetaxel at the Ottawa Hospital over a 5-year period. Charts were reviewed to collect clinical data to determine the incidence of FN. A multiple logistic regression was used to identify predictors of FN.
Results
In patients receiving docetaxel for mCRPC, the incidence of FN and neutropenia was 34/137 (25%) and 45/137 (33%), respectively. Among 34 patients who developed FN, 94% required hospitalization for FN for a mean of 5 days (+/- 2.8) and 6% died. Following FN, 53% required at least 1 treatment delay, 71% had at least 1 dose reduction and 18% received secondary prophylaxis with WBC Growth-Factors. Age category [OR 2.025, 95% CI 1.13–3.627] and presence of multiple comorbidities [OR 1.466, 95% CI 1.01–2.258] increased the risk of FN.
Conclusion
The incidence of FN and neutropenia in the clinical setting in patients receiving docetaxel for mCRPC is higher than previously reported and high enough to consider primary prophylaxis in high-risk groups. Age and multiple comorbidities were identified as risk factors.
Orientation controls tribological performance of 3D-printed model thermoplastics
Authors: Mahmood Samsul , Guo Emily , Sterling Amanda J. , Schulze Kyle D. 
Published: November 2022

Abstract
Additive manufacturing is rapidly growing in popularity due to its capability to produce parts with customized mechanical properties. Recent studies show that mechanical properties can be altered in a controlled manner by adjusting the relationship between build orientation and the applied loading from the service. In this work, the effect of build orientation on the tribological properties of 3D printed PLA – Polylactic acid and ABS- Acrylonitrile butadiene styrene is investigated. PLA and ABS samples are printed using material extrusion with three different build orientations. Tribological results show that variation in build direction relative to the sliding direction leads to anisotropic wear properties. The best wear properties are achieved when the layers are oriented orthogonally to the sliding direction. The coefficient of friction remains mostly unaffected by the build orientation. PLA samples demonstrate significantly better tribological properties compared to ABS. Varying the sliding speed between the interacting surfaces also affects the wear properties of both PLA and ABS. The results suggest that optimizing the build orientation with respect to service loading can improve the wear performance of additively manufactured thermoplastics. This presents an additional paradigm when designing additively manufactured parts potentially for functionally graded materials.
A new interval constructed belief rule base with rule reliability
Authors: Cheng Xiaoyu , Han Peng , He Wei , Zhou Guohui 
Published: November 2022

Abstract
Combination rule explosion problem of belief rule base (BRB) is a difficult problem to solve in complex systems and has attracted wide attention at present. Aiming at the problem of combination rule explosion in belief rule base, a new interval constructed belief rule base with rule reliability (IBRB-r) is proposed. On the basis of BRB, IBRB-r innovatively introduced rule reliability and established the belief table in the form of interval. This approach can not only clearly indicate the contribution degree of each rule to the model but also solve the problem of combination rule explosion. Therefore, IBRB-r is more suitable for complex system modeling. In the case study section, the structural safety assessment of liquid launch vehicle is introduced to conduct a concrete example analysis. The experimental results show that the proposed model is effective and accurate.
Targeting focal adhesion kinase boosts immune response in KRAS/LKB1 co-mutated lung adenocarcinoma via remodeling the tumor microenvironment
Authors: Qiao Meng , Zhou Fei , Liu Xinyu , Jiang Tao , Wang Haowei , Li Xuefei , Zhao Chao , Cheng Lei , Chen Xiaoxia , Ren Shengxiang , Wang Zaiqi , Zhou Caicun 
Published: November 2022

Abstract
Background
KRAS mutation is one of the most common oncogenic drivers in NSCLC, however, the response to immunotherapy is heterogeneous owing to the distinct co-occurring genomic alterations. KRAS/LKB1 co-mutated lung adenocarcinoma displays poor response to PD-1 blockade whereas the mechanism remains undetermined.
Methods
We explored the specific characteristics of tumor microenvironment (TME) in KL tumors using syngeneic KRASG12DLKB1−/−(KL) and KRASG12DTP53−/− (KP) lung cancer mouse models. The impact of focal adhesion kinase (FAK) inhibitor on KL lung tumors was investigated in vitro and in vivo through evaluation of both KL cell lines and KL lung cancer mouse models.
Results
We identified KL tumors as “immune-cold” tumors with excessive extracellular matrix (ECM) collagen deposition that formed a physical barrier to block the infiltration of CD8+T cells. Mechanistically, abundant activated cancer-associated fibroblasts (CAFs) resulted from FAK activation contributed to the formation of the unique TME of KL tumors. FAK inhibition with a small molecular inhibitor could remodel the TME by inhibiting CAFs activation, decreasing collagen deposition and further facilitating the infiltration of anti-tumor immune cells, including CD8+ T cells, DC cells and M1-like macrophages into tumors, hence, converting “immune-cold” KL tumors into “immune-hot” tumors. The combined FAK inhibitor and PD-1 blockade therapy synergistically retarded primary and metastatic tumor growth of KL tumors.
Conclusions
Our study identified FAK as a promising intervention target for KL tumors and provided basis for the combination of FAK inhibitor with PD-1 blockade in the management of KL lung cancers.
Species Composition, Structure and Regeneration Status of Woody Plants and Anthropogenic Disturbances in Zijje Maryam Church Forest, Ethiopia
Authors: Mekonnen Amare Bitew , Wassie Wubetie Adinew , Ayalew Habtemaryam , Gebreegziabher Berhane Gebreslassie 
Published: November 2022

Abstract
Our current study was conducted in Zijje Maryam Church forest, Ethiopia, to explore woody species composition, structure, regeneration status, and anthropogenic disturbances inside the sacred groves. The aforementioned information for adequate conservation and management of the church forest is not well documented. Fifteen main quadrats each having an area of 625m2(25m×25m) were used for vegetation and disturbance data collection. Determination of the sampled quadrants was based on the principle that minimum quadrats give the smallest possible area in which all species occurring in the church forest are present. All woody species with diameter at breast height (DBH) ≥ 2.5cm within the quadrat were identified, counted, and their height and DBH data were recorded. The criterion to start at DBH) ≥ 2.5cm was to exclude seedlings having DBH < 2.5 cm and height ≤ 0.6m. Sapling and seedling data were collected using 45 saplings and 45 seedling quadrat that measured 4 m2 and 1m2, respectively. Vegetation data analysis and ANOVA were used for statistical comparison. A total of 48 woody plant species belonging to 46 genera and 36 families were identified. Fabaceae was the dominant family containing 5 species followed by Rosaceae with 3 species. Total basal area of the church forest was 83.03m2 ha− 1. The density of seedlings, saplings, and matured woody species stem ha− 1 were 15555, 3833, and 865, respectively. Talking these densities, regeneration status of the forest was good. The Shannon diversity and evenness of woody plant species in the forest was high; 3.29 and 0.85, respectively. Juniperus procera 27.67 (9.22%) and Olea europaea were species with the highest IVI. Nearly, 22% of areas of the forest get disturbed and higher anthropogenic disturbances occurred near the edge of the forest. Gathering, clearing, and grazing are the major human disturbances that stakeholders need to tackle for conservation. Zijje Maryam church forest has heterogeneous species composition with varied seedlings and saplings. Therefore, local conservation policies recommended not only protect large forests, but also the small and valuable forests service to the needs of local people.
Molecular Characterization of Measles Viruses in Central African Republic, 2012-2016
Authors: Dote Joël , Tricou Vianney , Gnikpingo Laure Kaye , Pagonendji Marilou , Charpentier Emilie , Hübschen Judith M. , GOUANDJIKA Ionela 
Published: November 2022

Abstract

Despite being preventable through vaccination, measles is still one of the most important causes of morbidity and mortality in young children in Africa. In 2015, several African countries, including the Central African Republic, began implementing national measles elimination programs. However, measles remains a public health problem in Africa, particularly in the Central African Republic. A retrospective study was conducted at the Institut Pasteur de Bangui, using blood samples (n = 255) and oral swabs (n = 7) collected between January 2012 and December 2016 from measles IgM positive cases to attempt genotyping of circulating measles virus strains. Overall, 50 samples were positive by RT-PCR, and 40 sequences of acceptable quality were obtained. The phylogenetic analysis showed that 38 strains belonged to genotype B3 suggesting that the genotype B3 was endemic in the CAR during the study period. No genotype B2 sequences were detected, suggesting that this genotype is no longer present in the CAR.
Sustainable Strategies for Indian coal sector: An Econometric Analysis Approach
Authors: Mishra Animesh , Das Niladri , Mishra Brajesh 
Published: November 2022

AbstractThe thermal power generation based on coal has been identified as the second-largest polluting industry, owing to greenhouse gas emissions caused by coal combustion. The pollution caused by the industry is not limited to generation but is manifested all through product usage. Though the colossal emphasis is being given to replacing coal-based power generation with renewable resources, we proved that Indian power generation would depend on coal for more than fifty percent of its demand in the near future. We employed a mix of linear cointegration, non-linear cointegration, and ARIMA followed by the VECM model to forecast the use of coal based on the Indian industrial index and the extent of electricity generated through coal combustion required to fulfill the demand. As pollution and carbon emissions manifest the coal usage cycle, policy implications and recommendations are drafted to mitigate the consequences, greening the coal usage cycle and coal supply chain.
Benchmarking anion-exchange membranes for electrocatalytic carbon monoxide reduction
Authors: Jiao Feng 
Published: November 2022

Abstract
Performing carbon monoxide reduction in membrane electrode assembly configuration (MEA) is critical to achieving a high reaction rate while reducing cell resistance. Most studies examine the role of the cathode on product selectivity and cell stability, and comparatively, little attention has been given to the membrane impact on cell performance. This study demonstrates that membrane properties such as water uptake, ion exchange capacity, and functional groups alter the liquid product selectivity. Interestingly, we show that high ethanol crossover in conjunction with a suitable anode (NiFeOx) tunes the acetate selectivity. Overall, membrane properties significantly affect cell stability and product selectivity in a membrane electrode assembly configuration.
How could China’s CO2 Emission Per Capita decrease?The Analysis of Hybrid Influencing Factors and Improving Scenarios
Authors: Wang Dawei , Shen Wenxing , Zhang Shengliang 
Published: November 2022

Abstract
Reducing carbon emissions per capita has been one of the vital goals of sustainable development of the world's energy and human health since the 18th century. Unfortunately, China had become one of the world's largest carbon emitting country for the last 13 years which carbon dioxide emissions accounting for more than 25% of the world's total carbon emissions in 2018. Therefore, this article firstly to apply the IPAT and STIRPAT model to analyze the influencing factors of carbon emissions per capita which will be used to build the VENSIM model. It can be conducted that the main factors including industrial structure, energy structure, population and technology factors and social fixed assets investment. Then, the paper carries out for three simulating scenarios which are baseline scenario, reduction scenario and limited scenario, respectively.The simulation results show that the total CO2 intensity of the limited scenario will reach 0.80 million tons/per yuan as the lowest point in 2030. Finally, the paper combines carbon system simulation results, based on the influence factors of city carbon emissions system, low carbon economy, energy and social system of low carbon city development suggestions are put forward to solve these issues.
Submarine landslide tsunami hazard assessment for the Western Makran based on a deterministic approach
Authors: Nouri Mohammadsadegh , Rashidi Amin , Namin Masoud Montazeri , Shugar Dan H 
Published: November 2022

Abstract
The Makran region, which borders southern Iran and Pakistan along the Gulf of Oman, has experienced multiple tsunamis in the last century, with some being triggered by submarine landslides. However, the role played by submarine landslides has been largely neglected in tsunami hazard assessments in the western Makran. In the present study, four different landslide scenarios with volumes of 10-40 km3 are simulated on 25 different locations in the western Makran, resulting in 100 different hypothetical scenarios. The results indicate that Oman’s coastline, a country in the western part of Makran subduction zone, is more vulnerable to the hazard of landslide-generated waves (maximum average of 3.1 m wave height) compared to Iran (maximum average 0.9 m height). Although Chabahar, Iran, and Muscat, Oman, two major cities in the region, experienced severe waves during some scenarios, it can be implied Muscat is more vulnerable to this kind of tsunami due to the significant gap between the maximum and average wave height for all scenarios. We further discuss that applying hypothetical worst-case scenarios can sometimes lead to an overestimation in tsunami hazard assessment. Therefore, more geological, sedimentological, and geotechnical considerations and studies are required for defining submarine landslide worst-case scenarios.