bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current research and industrial application of laser powder directed energy deposition
Authors: Piscopo Gabriele , Iuliano Luca 
Published: January 2022

AbstractAdditive Manufacturing (AM) technologies are recognized as the future of the manufacturing industry thanks to their possibilities in terms of shape design, part functionality, and material efficiency. The use of AM technologies in many industrial sectors is growing, also due to the increasing knowledge regarding the AM processes and the characteristics of the final part. One of the most promising AM techniques is the Directed Energy Deposition (DED) that uses a thermal source to generate a melt pool on a substrate into which metal powder is injected. The potentialities of DED technology are the ability to process large build volumes (> 1000 mm in size), the ability to deliver the material directly into the melt pool, the possibility to repair existing parts, and the opportunity to change the material during the building process, thus creating functionally graded material. In this paper, a review of the industrial applications of Laser Powder Directed Energy Deposition (LP-DED) is presented. Three main applications are identified in repairing, designed material, and production. Despite the enormous advantages of LP-DED, from the literature, it emerges that the most relevant application refers to the repairing process of high-value components.
Bacteria-targeted fluorescence imaging of extracted osteosynthesis devices for rapid visualization of fracture-related infections
Authors: López-Álvarez Marina , Heuker Marjolein , Sjollema Klaas A. , van Dam Gooitzen M. , van Dijl Jan Maarten , IJpma Frank F. A. , van Oosten Marleen 
Published: January 2022

Abstract
Purpose
Fracture-related infection (FRI) is a serious complication in orthopedic trauma surgery worldwide. Especially, the distinction of infection from sterile inflammation and the detection of low-grade infection are highly challenging. The objective of the present study was to obtain proof-of-principle for the use of bacteria-targeted fluorescence imaging to detect FRI on extracted osteosynthesis devices as a step-up towards real-time image-guided trauma surgery.

Methods
Extracted osteosynthesis devices from 13 patients, who needed revision surgery after fracture treatment, were incubated with a near-infrared fluorescent tracer composed of the antibiotic vancomycin and the fluorophore IRDye800CW (i.e., vanco-800CW). Subsequently, the devices were imaged, and vanco-800CW fluorescence signals were correlated to the results of microbiological culturing and to bacterial growth upon replica plating of the imaged devices on blood agar.

Results
Importantly, compared to culturing, the bacteria-targeted fluorescence imaging of extracted osteosynthesis devices with vanco-800CW allows for a prompt diagnosis of FRI, reducing the time-to-result from days to less than 30 min. Moreover, bacteria-targeted imaging can provide surgeons with real-time visual information on the presence and extent of infection.

Conclusion
Here, we present the first clinical application of fluorescence imaging for the detection of FRI. We conclude that imaging with vanco-800CW can provide early, accurate, and real-time visual diagnostic information on FRI in the clinical setting, even in the case of low-grade infections.

Graphical abstract
Comparison of acute myeloid leukemia and myelodysplastic syndromes with TP53 aberrations
Authors: Dutta Sayantanee , Moritz Jennifer , Pregartner Gudrun , Thallinger Gerhard G. , Brandstätter Ilona , Lind Karin , Rezania Simin , Lyssy Freya , Reinisch Andreas , Zebisch Armin , Berghold Andrea , Wölfler Albert , Sill Heinz 
Published: January 2022

AbstractTP53 aberrations are found in approximately 10% of patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) and are considered early driver events affecting leukemia stem cells. In this study, we compared features of a total of 84 patients with these disorders seen at a tertiary cancer center. Clinical and cytogenetic characteristics as well as immunophenotypes of immature blast cells were similar between AML and MDS patients. Median overall survival (OS) was 226 days (95% confidence interval [CI], 131–300) for the entire cohort with an estimated 3-year OS rate of 11% (95% CI, 6–22). OS showed a significant difference between MDS (median, 345 days; 95% CI, 235–590) and AML patients (median, 91 days; 95% CI, 64–226) which is likely due to a different co-mutational pattern as revealed by next-generation sequencing. Transformation of TP53 aberrant MDS occurred in 60.5% of cases and substantially reduced their survival probability. Cox regression analysis revealed treatment class and TP53 variant allele frequency as prognostically relevant parameters but not the TP53-specific prognostic scores EAp53 and RFS. These data emphasize similarities between TP53 aberrant AML and MDS and support previous notions that they should be classified and treated as a distinct disorder.
Weiterentwicklung und Inhaltsvalidierung eines Fragebogens zur Erfassung des Wissens über das Delir
Authors: Zilezinski Max , Lohrmann Renée , Hauß Armin , Bergjan Manuela 
Published: January 2022

Zusammenfassung
Hintergrund
Das Delir ist ein neuropsychiatrisches Syndrom, welches häufig ältere Patient_innen betrifft und schwerwiegende Folgen haben kann. Oftmals wird es vom Gesundheitspersonal nicht erkannt. Der Wissensstand über das Delir ist beim pflegerischen und ärztlichen Personal häufig unzureichend ausgeprägt. Zum aktuellen Zeitpunkt fehlt im deutschsprachigen Raum ein Fragebogen zur Erfassung des Wissensstands.

Ziel
Weiterentwicklung eines Fragenbogens und Bewertung der Inhaltsvalidität.

Methode
Im Rahmen einer Literaturrecherche wurden mehrere Fragebögen identifiziert. Ein bereits publizierter Fragebogen mit den Dimensionen Grundlagenwissen über das Delir und Risikofaktoren ist übersetzt, angepasst und um die Dimension der nichtpharmakologischen Delirprävention erweitert worden. Die Bewertung der Fragebogenitems erfolgte durch Delirexpert_innen in 2 Runden. Die Inhaltsvalidität wurde anhand des Content Validity Index (CVI) auf Item(I-CVI)- und Skalen(S-CVI)-Level angegeben, zusätzlich wurde der „modified Kappa“ (κ*) mit der Untergrenze des 95 %igen Konfidenzintervalls (KI) berechnet.

Ergebnisse
Der 30 Items umfassende Originalfragebogen wurde um 18 Items der Delirprävention erweitert. Nach der ersten Bewertungsrunde durch 13 Expert_innen zeigten 30 von 48 Items gute bis exzellente I‑CVI-Werte (0,78–1,0). Unter Berücksichtigung der Kommentare wurden 6 Items verworfen und 12 Items sprachlich und inhaltlich adaptiert. In der finalen Version des Fragebogens verblieben 41 Items mit exzellenten Werten (1,0). Der Gesamtskalenwert hatte sich von 0,88 in der ersten Version auf 1,0 in der finalen Version erhöht. Als Zielgruppe wurden Pflegefachpersonen identifiziert, aber potenziell auch therapeutisches und ärztliches Personal.

Schlussfolgerung
Der Fragebogen zur Erfassung des Wissens über das Delir ist inhaltsvalide.
What interventions affect the psychosocial burden experienced by prostate cancer patients undergoing active surveillance? A scoping review
Authors: Donachie Kim , Cornel Erik , Pelgrim Thomas , Michielsen Leslie , Langenveld Bart , Adriaansen Marian , Bakker Esther , Lechner Lilian 
Published: January 2022

Abstract
Purpose
Living with untreated prostate cancer (PCa) may cause anxiety and uncertainty in men undergoing active surveillance (AS). Developing a psychosocial support program for such patients might promote psychosocial well-being and patient engagement. This review aims to identify interventions with the potential to influence the psychosocial burden of prostate cancer patients undergoing AS.

Methods
A scoping review was conducted in accordance with the PRISMA Extension for Scoping Reviews Checklist. A systematic search was conducted in six databases and included publications dating from 2009. All available and eligible evidence was included in this review.

Results
After screening 2824 articles, 12 studies were included in the review: nine quantitative, one qualitative, and two mixed method papers. The relative strength of these studies was limited and the quality of most was moderate.

Conclusions
The described interventions can be categorized into three major themes: information and education, coping and (psycho)social support, and lifestyle. Psychosocial support for men undergoing AS should entail involvement of family and spouse during the decision-making process, tailored information about PCa treatments, risks, benefits, protocols, lifestyle adjustments, and complementary and alternative medicine. Assessment and promotion of effective coping and self-management strategies are recommended. Healthcare providers should actively promote physical activity and nutritional improvements. Physical activity programs may also be helpful in facilitating peer support, which is especially important for men with limited social support. Future research should investigate combining interventions to increase efficacy and optimize supportive care during AS.
Telemedicine and psoriatic arthritis: best practices and considerations for dermatologists and rheumatologists
Authors: Gottlieb Alice B. , Wells Alvin F. , Merola Joseph F. 
Published: January 2022

AbstractTelemedicine encompasses a variety of modalities that allow for the remote assessment and treatment of patients. The technologies, services, and tools available for telemedicine in the USA are increasingly becoming an integral part of the healthcare system to bridge the gaps in care that can arise from geographic and/or socioeconomic obstacles and provider shortages. Telemedicine can be applied to a spectrum of clinical areas, including rheumatic diseases. Psoriatic arthritis (PsA) is a chronic, inflammatory, multisystem disease with predominately skin and joint manifestations. PsA is often misdiagnosed and/or undiagnosed, which can lead to worse patient outcomes, including irreversible joint erosion and damage. The difficulties in diagnosing and managing PsA are confounded by the emergence and increased use of telemedicine because of the COVID-19 pandemic. Telemedicine presents the opportunity to increase access to healthcare by rheumatologists and dermatologists to improve training and education regarding PsA and to decrease time attributed to office visits associated with PsA. However, challenges in diagnosing PsA without a thorough in-person physical examination by a trained rheumatologist or dermatologist exist. We provide an overview of the ways telemedicine can be incorporated into clinical care and optimized for patients with PsA; characteristic clinical features of PsA, with a focus on skin and joint signs and symptoms; screening tools to be used in routine clinical care; assessments that can be used to evaluate quality of life, functional ability, and disease activity in PsA; and resources and recommendations for the development of future telemedicine use in rheumatology and dermatology.

Key Points• Patients with psoriatic arthritis (PsA) are often misdiagnosed and/or undiagnosed.• Telemedicine can improve access to healthcare by rheumatologists and dermatologists.• Telemedicine can be incorporated into clinical care and optimized for managing PsA.
Phase-Amplitude Coupling and Phase Synchronization Between Medial Temporal, Frontal and Posterior Brain Regions Support Episodic Autobiographical Memory Recall
Authors: Roehri Nicolas , Bréchet Lucie , Seeber Martin , Pascual-Leone Alvaro , Michel Christoph M. 
Published: January 2022

AbstractEpisodic autobiographical memory (EAM) is a complex cognitive function that emerges from the coordination of specific and distant brain regions. Specific brain rhythms, namely theta and gamma oscillations and their synchronization, are thought of as putative mechanisms enabling EAM. Yet, the mechanisms of inter-regional interaction in the EAM network remain unclear in humans at the whole brain level. To investigate this, we analyzed EEG recordings of participants instructed to retrieve autobiographical episodes. EEG recordings were projected in the source space, and time-courses of atlas-based brain regions-of-interest (ROIs) were derived. Directed phase synchrony in high theta (7–10 Hz) and gamma (30–80 Hz) bands and high theta-gamma phase-amplitude coupling were computed between each pair of ROIs. Using network-based statistics, a graph-theory method, we found statistically significant networks for each investigated mechanism. In the gamma band, two sub-networks were found, one between the posterior cingulate cortex (PCC) and the medial temporal lobe (MTL) and another within the medial frontal areas. In the high theta band, we found a PCC to ventromedial prefrontal cortex (vmPFC) network. In phase-amplitude coupling, we found the high theta phase of the left MTL biasing the gamma amplitude of posterior regions and the vmPFC. Other regions of the temporal lobe and the insula were also phase biasing the vmPFC. These findings suggest that EAM, rather than emerging from a single mechanism at a single frequency, involves precise spatio-temporal signatures mapping on distinct memory processes. We propose that the MTL orchestrates activity in vmPFC and PCC via precise phase-amplitude coupling, with vmPFC and PCC interaction via high theta phase synchrony and gamma synchronization contributing to bind information within the PCC-MTL sub-network or valuate the candidate memory within the medial frontal sub-network.
Periodontal disease as a risk factor for sporadic colorectal cancer: results from COLDENT study
Authors: Idrissi Janati Amal , Karp Igor , Latulippe Jean-François , Charlebois Patrick , Emami Elham 
Published: January 2022

AbstractColorectal cancer remains the top leading cancer worldwide. Accumulating evidence suggests periodontal pathogens are involved in colorectal carcinogenesis, indicating the need for high-quality epidemiological evidence linking periodontal disease (PD) and colorectal cancer (CRC). Thus, we conducted the first population-based case–control study that was specifically designed to investigate the association between compromised oral health and sporadic CRC. A total of 348 incident cases of colon or rectal cancer, and 310 age and sex frequency-matched controls, from the Montreal island and Laval population participated in the study. Data were collected on PD and on several CRC risk factors using validated questionnaires. A life-course approach was used to document long-term history regarding lifestyle factors. Multivariable unconditional logistic regression analysis was used to estimate the rate ratio (RR) quantifying the association between CRC and PD. Results showed that the rate of new diagnosis of CRC in persons with a positive history of PD was 1.45 times higher than in those with a negative history of PD adjusting for age, sex, BMI, education, income, diabetes, family history of CRC, regular use of non-steroidal anti-inflammatory drugs, lifetime cumulative smoking, lifetime consumption of red meats, processed meats, and alcoholic drinks, and lifetime total physical activity score (adjusted RR = 1.45; 95% CI 1.04–2.01; p = 0.026). Our results support the hypothesis of an association between PD and sporadic CRC risk.
Chilean Consumer Law and Policy: A Brief Outlook
Authors: Andrade V. 
Published: January 2022

AbstractChilean consumer law and policy has a short but enthralling history. As compared with other jurisdictions such as EU countries, its bedrock is still in formation, particularly pertaining to its envisaged role in the regulatory spectrum applicable to consumer markets. However, this circumstance has not been a serious obstacle to several reforms carried out in recent years aimed at broadening its scope of action, including rethinking a proposal regarding the policy goals to be addressed by the national consumer agency, SERNAC. In that context, this article presents a brief account of the main features of Chilean consumer law, considering the current socioeconomic development level of the country, the main pieces of legislation concerning consumer protection in the Chilean legal framework—notably the Chilean Consumer Protection Act—as well as key elements of the public policy approach in this matter. A few examples of topics such as product liability and sale and purchase of consumer goods are also analysed in order to allow a comparison of the Chilean experience in consumer protection with other jurisdictions.
Pre-service primary teachers’ shame experiences during their schooling time: characteristics and effects on their subject-choices at university
Authors: Jenßen Lars , Möller Regina , Eilerts Katja , Roesken-Winter Bettina 
Published: January 2022

AbstractEmotions play an essential role in pre-service teachers’ competence development, particularly in mathematics. However, the emotion of shame in mathematics has been largely neglected so far. This article deals with shameful experiences of pre-service primary school teachers during their mathematical education at school and the various effects of shame on their decision to study mathematics as a subject at university. The research consists of a qualitative and a quantitative study with 311 prospective primary school teachers who responded to a survey about their experiences of shame in mathematics at school when they were students. Results of the qualitative study emphasize the different experiences in mathematics during the school years and reveal the characteristics of these situations, for example, social exposure or competition games. In the quantitative study, pre-service primary teachers’ subject choice was analyzed in relation to their experienced shame in mathematics at school. Results reveal that shame experienced at school has effects on the initial choice in favor of mathematics at university. Implications for primary teacher education are finally discussed.
Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers
Authors: Fujita Arimi , Noguchi Saki , Hamada Rika , Inoue Satoko , Shimada Tsutomu , Katakura Satomi , Maruyama Tetsuo , Sai Yoshimichi , Nishimura Tomohiro , Tomi Masatoshi 
Published: January 2022

Abstract
Purpose
Multidrug resistance protein 1 (MDR1) is located at the interface between two syncytiotrophoblast layers in rodent placenta, and may influence fetal drug distribution. Here, we quantitatively compare the functional impact per single MDR1 molecule of MDR1 at the placental barrier and blood-brain barrier in mice.

Methods
MDR1A and MDR1B proteins were quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Paclitaxel or digoxin was continuously administered to pregnant Mdr1a−/−/Mdr1b−/− or wild-type mice, and the drug concentrations in the maternal and fetal plasma and maternal brain were quantified by LC-MS/MS.

Results
MDR1A and MDR1B proteins are expressed in the membrane of mouse placental labyrinth, and total MDR1 at the placental barrier amounts to about 30% of that at the blood-brain barrier. The fetal-to-maternal plasma concentration ratio of digoxin was only marginally affected in Mdr1a−/−/Mdr1b−/− mice, while that of paclitaxel showed a several-fold increase. No such difference between the two drugs was found in the maternal brain distribution. The impact per single MDR1 molecule on the fetal distribution of digoxin was calculated to be much lower than that on the brain distribution, but this was not the case for paclitaxel. Our pharmacokinetic model indicates that the impact of placental MDR1 is inversely correlated to the ratio of permeability through gap junctions connecting the two syncytiotrophoblast layers to passive diffusion permeability.

Conclusion
Our findings indicate that murine placental MDR1 has a minimal influence on the fetal concentration of certain substrates, such as digoxin, due to bypass transfer, probably via connexin26 gap junctions.
An evolving international research collaboration network: spatial and thematic developments in co-authored higher education research, 1998–2018
Authors: Fu Yuan Chih , Marques Marcelo , Tseng Yuen-Hsien , Powell Justin J. W. , Baker David P. 
Published: January 2022

AbstractCo-authored research articles in the disciplinarily heterogeneous field of higher education have dramatically increased in this century. As in other fields, rising international co-authorships reflect evolving international collaboration networks. We examine higher education research over two decades, applying automated bibliometric topic identification and social network analysis of 9067 papers in 13 core higher education journals (1998–2018). Remarkable expansion in the volume of papers and co-authorships has, surprisingly, not resulted in a more diverse network. Rather, existing co-authorship patterns are strengthened, with the dominance of scholars from a few Anglophone countries largely maintained. Researchers globally seek to co-author with leading scholars in these countries, especially the US, UK, and Australia—at least when publishing in the leading general higher education journals based there. Further, the two-mode social network analysis of countries and topics suggests that while Anglophone countries have led the development of higher education research, China and Germany, as leading research-producing countries, are increasingly influential within this world-spanning network. Topically, the vast majority of co-authored papers in higher education research focuses on individual-level phenomena, with organizational and system or country-level analysis constituting (much) smaller proportions, despite policymakers’ emphasis on cross-national comparisons and the growing importance of university actorhood. We discuss implications thereof for the future of the multidisciplinary field of higher education.
Sports and Cultural Volunteering: Competitive or Complementary Activities?
Authors: Hallmann Kirstin , Artime Cristina Muñiz 
Published: January 2022

AbstractWhile nonprofit organizations have traditionally been considered increasingly competing for resources, this paper mainly explores the potential mutual relationship between volunteering in sport and volunteering in culture. Drawing on 2014 data from the German Volunteer Survey, we estimated a bivariate probit model based on 27,293 observations. The findings suggested that sports and cultural volunteering were complementary activities. Thus, promoting volunteering in one of the domains positively affected volunteering in the alternative domain. Parental volunteering, religiosity, and education were primary drivers of both types of volunteering. However, differences in some determinants have also been found. For example, volunteering in culture was predominantly female, while male volunteers dominated sports.
Improving the Summer Power Generation of a Hydropower Reservoir Using the Modified Multi-Step Ahead Time-Varying Hedging Rule
Authors: Thiha Soe , Shamseldin Asaad Y. , Melville Bruce W. 
Published: January 2022

AbstractThis paper aims to improve summer power generation of the Yeywa Hydropower Reservoir in Myanmar using the modified multi-step ahead time-varying hedging (TVH) rule as a case study. The results of the TVH rules were compared with the standard operation policy (SOP) rule, the binary standard operation policy (BSOP) rule, the discrete hedging (DH) rule, the standard hedging (SH) rule, the one-point hedging (OPH) rule, and the two-point hedging (TPH) rule. The Multi-Objective Genetic Algorithm (MOGA) was utilized to drive the optimal Pareto fronts for the hedging rules. The results demonstrated that the TVH rules had higher performance than the other rules and showed improvements in power generation not only during the summer period but also over the entire period.