bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinetics and persistence of cellular and humoral immune responses to SARS‐CoV‐2 vaccine in healthcare workers with or without prior COVID‐19
Authors: Chivu‐Economescu Mihaela , Bleotu Coralia , Grancea Camelia , Chiriac Daniela , Botezatu Anca , Iancu Iulia V. , Pitica Ioana , Necula Laura G. , Neagu Ana , Matei Lilia , Dragu Denisa , Sultana Camelia , Radu Elena L. , Nastasie Alina , Voicu Oana , Ataman Marius , Nedeianu Saviana , Mambet Cristina , Diaconu Carmen C. , Ruta Simona Maria 
Published: January 2022

AbstractSARS‐CoV‐2 vaccines are highly efficient against severe forms of the disease, hospitalization and death. Nevertheless, insufficient protection against several circulating viral variants might suggest waning immunity and the need for an additional vaccine dose. We conducted a longitudinal study on the kinetics and persistence of immune responses in healthcare workers vaccinated with two doses of BNT162b2 mRNA vaccine with or without prior SARS‐CoV‐2 infection. No new infections were diagnosed during follow‐up. At 6 months, post‐vaccination or post‐infection, despite a downward trend in the level of anti‐S IgG antibodies, the neutralizing activity does not decrease significantly, remaining higher than 75% (85.14% for subjects with natural infection, 88.82% for vaccinated after prior infection and 78.37% for vaccinated only). In a live‐virus neutralization assay, the highest neutralization titres were present at baseline and at 6 months follow‐up in persons vaccinated after prior infection. Anti‐S IgA levels showed a significant descending trend in vaccinated subjects (p < 0.05) after 14 weeks. Cellular immune responses are present even in vaccinated participants with declining antibody levels (index ratio 1.1–3) or low neutralizing activity (30%–40%) at 6 months, although with lower T‐cell stimulation index (p = 0.046) and IFN‐γ secretion (p = 0.0007) compared to those with preserved humoral responses.
Genetic traces of hybrid zone movement across a fragmented habitat
Authors: Sequeira Fernando , Arntzen Jan W. , van Gulik Davy , Hajema Steven , Diaz Ruben Lopez , Wagt Mattijn , van Riemsdijk Isolde 
Published: January 2022

AbstractTheoretical and empirical studies suggest that the structure and position of hybrid zones can change over time. Evidence for moving hybrid zones has been directly inferred by repeated sampling over time, or indirectly through the detection of genetic footprints left by the receding species and the resulting asymmetric patterns of introgression across markers. We here investigate a hybrid zone formed by two subspecies of the Iberian golden‐striped salamander,Chioglossa lusitanica, using a panel of 35 nuclear loci (31 SNPs and 4 allozymes) and one mitochondrial locus in a transect in central Portugal. We found concordant and coincident clines for most of the nuclear loci (n = 22, 63%), defining a narrow hybrid zone of ca. 6 km wide, with the centre positioned ca. 15 km south of the Mondego River. Asymmetric introgression was observed at another 14 loci. Their clines are displaced towards the north, with positions located either close to the Mondego River (n = 6) or further northwards (n = 8). We interpret these profiles as genetic traces of the southward displacement ofC.lusitanica lusitanicabyC.l.longipesover the wider Mondego River valley. We noted the absence of significant linkage disequilibrium, and we inferred low levels of effective selection per locus against hybrids, suggesting that introgression in the area of species replacement occurred under a neutral diffusion process. A species distribution model suggests that theC.lusitanicahybrid zone coincides with a narrow corridor of fragmented habitat. From the position of the displaced clines, we infer that patches of locally suitable habitat trapped some genetic variants that became disassociated from the southward moving hybrid zone. This study highlights the influence of habitat availability on hybrid zone movement.
Neuroendocrine control of gonadotropin‐releasing hormone: Pulsatile and surge modes of secretion
Authors: Goodman Robert L. , Herbison Allan E. , Lehman Michael N. , Navarro Victor M. 
Published: January 2022

AbstractThe concept that different systems control episodic and surge secretion of gonadotropin‐releasing hormone (GnRH) was well established by the time that GnRH was identified and formed the framework for studies of the physiological roles of GnRH, and later kisspeptin. Here, we focus on recent studies identifying the neural mechanisms underlying these two modes of secretion, with an emphasis on their core components. There is now compelling data that kisspeptin neurons in the arcuate nucleus that also contain neurokinin B (NKB) and dynorphin (i.e., KNDy cells) and their projections to GnRH dendrons constitute the GnRH pulse generator in mice and rats. There is also strong evidence for a similar role for KNDy neurons in sheep and goats, and weaker data in monkeys and humans. However, whether KNDy neurons act on GnRH dendrons and/or GnRH soma and dendrites that are found in the mediobasal hypothalamus (MBH) of these species remains unclear. The core components of the GnRH/luteinising hormone surge consist of an endocrine signal that initiates the process and a neural trigger that drives GnRH secretion during the surge. In all spontaneous ovulators, the core endocrine signal is a rise in estradiol secretion from the maturing follicle(s), with the site of estrogen positive feedback being the rostral periventricular kisspeptin neurons in rodents and neurons in the MBH of sheep and primates. There is considerable species variations in the neural trigger, with three major classes. First, in reflex ovulators, this trigger is initiated by coitus and carried to the hypothalamus by neural or vascular pathways. Second, in rodents, there is a time of day signal that originates in the suprachiasmatic nucleus and activates rostral periventricular kisspeptin neurons and GnRH soma and dendrites. Finally, in sheep nitric oxide‐producing neurons in the ventromedial nucleus, KNDy neurons and rostral kisspeptin neurons all appear to participate in driving GnRH release during the surge.
Is socialism back? A review of contemporary economic literature
Authors: Carnevali Emilio , Pedersen Ystehede André 
Published: January 2022

AbstractThe paper deals with the recent resurgence of interest in the concept of “socialism” from an economic perspective. The most significant contemporary proposals for a new model of socialism are surveyed across five major thematic areas: socialism as a voluntary endeavor and socialist ethics; socialism as a process of democratization; socialism, efficiency and profit maximization; the problem of planning and the new calculation debate; and, socialism as a means versus socialism as an end. A common framework to assess the new blueprints is constructed to identify the likely directions of the research on these themes in the near future.
Monetary Policy and Asset Valuation
Authors: BIANCHI FRANCESCO , LETTAU MARTIN , LUDVIGSON SYDNEY C. 
Published: January 2022

ABSTRACTWe document large, longer term, joint regime shifts in asset valuations and the real federal funds rate‐ spread. To interpret these findings, we estimate a novel macrofinance model of monetary transmission and find that the documented regimes coincide with shifts in the parameters of a policy rule, with long‐term consequences for the real interest rate. Estimates imply that two‐thirds of the decline in the real interest rate since the early 1980s is attributable to regime changes in monetary policy. The model explains how infrequent changes in the stance of monetary policy can generate persistent changes in asset valuations and the equity premium.
What is the nocebo effect and does it apply to dentistry?—A narrative review
Authors: Watanabe Takeshi , Sieg Mette , Lunde Sigrid Juhl , Taneja Pankaj , Baad‐Hansen Lene , Pigg Maria , Vase Lene 
Published: January 2022

AbstractBackgroundEvidence for the nocebo effect, a phenomenon characterised by suboptimal treatment efficacy, worsening of symptoms, or the occurrence of adverse events caused by an individual’s negative treatment expectations, is growing across a multitude of medical fields. However, little attention has been paid to patients’ negative expectations and the nocebo effect within dentistry.AimThis review summarises essential evidence of the nocebo phenomenon especially in relation to pain and drug administration. Subsequently, an overview of the current evidence of the nocebo phenomenon in the dental field is presented.MethodsA PubMed search was performed using keywords related to “nocebo,” “placebo,” “expectations,” and “dentistry.” In addition to the articles selected from the search, placebo/nocebo researchers and dental researchers added important references from their respective fields.ResultsAlthough research on the nocebo effect in dentistry is limited, available current evidence suggests that the factors, which is related to the nocebo effect are likely to play a role in dental practice.ConclusionPreliminary evidence from the review warrants further investigation into the nocebo effect in dentistry. Finally, based on the general knowledge of the nocebo effect, the review indicates fruitful arrays of research into the nocebo effect in dentistry.
Next generation models for portfolio risk management: An approach using financial big data
Authors: Jung Kwangmin , Kim Donggyu , Yu Seunghyeon 
Published: January 2022

AbstractThis paper proposes a dynamic process of portfolio risk measurement to address potential information loss. The proposed model takes advantage of financial big data to incorporate out‐of‐target‐portfolio information that may be missed when one considers the value at risk (VaR) measures only from certain assets of the portfolio. We investigate how the curse of dimensionality can be overcome in the use of financial big data and discuss where and when benefits occur from a large number of assets. In this regard, the proposed approach is the first to suggest the use of financial big data to improve the accuracy of risk analysis. We compare the proposed model with benchmark approaches and empirically show that the use of financial big data improves small portfolio risk analysis. Our findings are useful for portfolio managers and financial regulators, who may seek for an innovation to improve the accuracy of portfolio risk estimation.
Seeking Harmony Rather Than Efficiency: The Effect of Self‐Construal on Social Compensation1
Authors: Agata Ako , Ando Kaori , Kasagi Yu , Kugihara Naoki 
Published: January 2022

AbstractMany studies have discussed how motivation in task‐related groups is affected by culture. Despite this, the psychological processes underlying these cultural differences have not yet been fully investigated. This study examined the effects of self‐construal on social compensation, that is, motivation gain caused by the expectation of coworkers' poor performance. Participants were 111 Japanese undergraduate students. They were asked to engage in nine tasks as a team with a coworker whose intelligence was inferior or superior and allocate tasks between themselves and their coworkers. We measured the number of tasks that participants selected as their own work as a dependent measure. The results showed that those with interdependent selves were less likely to engage in social compensation even when their coworkers' capability was low.
Spontaneous Interpersonal Coordination in Stepping and Autistic‐Like Traits1
Authors: Nagai Masayoshi , Honma Motoyasu , Kumada Takatsune , Osada Yoshihisa 
Published: January 2022

AbstractSpontaneous behavior, matching that of others, is influenced by various social factors. Mimicking and synchronizing with others' behaviors can facilitate the development of harmonious relationships. This study examined whether the level of autistic‐like traits in a non‐clinical population influences the spontaneous‐behavioral coordination of a dyad's stepping‐on‐the‐spot movements. The strength of spontaneous stepping synchronization was negatively correlated with levels of autistic‐like traits when participants faced one another, and no synchronization was observed for individuals with high levels of autistic‐like traits. The deficit in spontaneous interpersonal behaviour‐matching among individuals with high levels of autistic‐like traits is discussed as a potential source of their poor social‐communication abilities.
Creating Equality Through Dialogue in a Narrative‐Based Helping Relationship1
Authors: Motoyama Tomonori 
Published: January 2022

AbstractThis study aims to examine dialogical techniques used to establish a relationship of equality between therapist and client in narrative‐based therapy. This paper first introduces a “mutual first‐personalization process” found in dialogue established through the Person‐Centered Approach and “early dialogues,” which is a framework that forms the foundation of Open Dialogue, to illuminate the relationship of equality created in these exchanges. The concept of the “middle voice” is then introduced to show that dialogical therapy generates a relationship that does not clearly distinguish between therapist and client, or “to help” and “to be helped,” and that equality is a key aspect of narrative‐based therapy.
Association between menstrual pain and functional dyspepsia in a Japanese young population
Authors: Yamamoto Yasunori , Furukawa Shinya , Watanabe Junichi , Miyake Teruki , Kato Aki , Kusumoto Katsunori , Takeshita Eiji , Ikeda Yoshio , Yamamoto Naofumi , Kohara Katsuhiko , Saheki Syuichi , Saeki Yuka , Hiasa Yoichi 
Published: January 2022

AbstractBackgroundFunctional dyspepsia (FD) is a very common disease worldwide. Dysmenorrhea impairs quality of life among females of reproductive age. Although dysmenorrhea is associated with irritable bowel syndrome (IBS), no study has yet evaluated the association between dysmenorrhea and FD.MethodsThis study's subjects consisted of 4693 female Japanese university students. We defined FD according to the Rome III criteria. Subjects completed a self‐reported questionnaire regarding menstrual irregularity, menstrual pain, and medication for menstrual pain. Age, body mass index, drinking, smoking, exercise habit, anemia, and first‐year student status were selected as potential confounding factors.ResultsThe prevalence of FD, epigastric pain syndrome (EPS), and postprandial distress syndrome (PDS) was 2.5%, 0.6%, and 2.1%, respectively. Heavy menstrual pain was independently positively associated with FD and PDS but not EPS (adjusted ORs: FD, 3.18 [95% CI: 1.60–6.89] and PDS, 2.93 [95% CI: 1.56–7.93] for heavy menstrual pain, p for trend = 0.001 and 0.004, respectively). Using medication for menstrual pain often was independently positively associated with FD, EPS, and PDS, respectively, (adjusted ORs: FD, 2.41 [95% CI: 1.50–3.83], EPS, 2.93 [95% CI: 1.04–7.93], PDS, 2.44 [95% CI: 1.46–4.01]). Irregular menstrual cycle was not associated with FD or with subtype of FD.ConclusionAmong the young female Japanese population, menstrual pain might be independently positively associated with FD and PDS but not EPS. The use of medication for menstrual pain might be independently positively associated with FD including subtype of FD.
Genetic and molecular mechanisms underlying root architecture and function under heat stress—A hidden story
Authors: Tiwari Manish , Kumar Ritesh , Min Doohong , Jagadish S. V. Krishna 
Published: January 2022

AbstractHeat stress events are resulting in a significant negative impact on global food production. The dynamics of cellular, molecular and physiological homoeostasis in aboveground parts under heat stress are extensively deciphered. However, root responses to higher soil/air temperature or stress signalling from shoot to root are limited. Therefore, this review presents a holistic view of root physio‐morphological and molecular responses to adapt under hotter environments. Heat stress reprogrammes root cellular machinery, including crosstalk between genes, phytohormones, reactive oxygen species (ROS) and antioxidants. Spatio‐temporal regulation and long‐distance transport of phytohormones, such as auxin, cytokinin and abscisic acid (ABA) determine the root growth and development under heat stress. ABA cardinally integrates a signalling pathway involving heat shock factors, heat shock proteins and ROS to govern heat stress responses. Additionally, epigenetic modifications by transposable elements, DNA methylation and acetylation also regulate root growth under heat stress. Exogenous application of chemical compounds or biological agents such as ascorbic acid, metal ion chelators, fungi and bacteria can alleviate heat stress‐induced reduction in root biomass. Future research should focus on the systemic effect of heat stress from shoot to root with more detailed investigations to decipher the molecular cues underlying the roots architecture and function.
Asymptotic Theory of Principal Component Analysis for Time Series Data with Cautionary Comments
Authors: Zhang Xinyu , Tong Howell 
Published: January 2022

AbstractPrincipal component analysis (PCA) is a most frequently used statistical tool in almost all branches of data science. However, like many other statistical tools, there is sometimes the risk of misuse or even abuse. In this paper, we highlight possible pitfalls in using the theoretical results of PCA based on the assumption of independent data when the data are time series. For the latter, we state with proof a central limit theorem of the eigenvalues and eigenvectors (loadings), give direct and bootstrap estimation of their asymptotic covariances, and assess their efficacy via simulation. Specifically, we pay attention to the proportion of variation, which decides the number of principal components (PCs), and the loadings, which help interpret the meaning of PCs. Our findings are that while the proportion of variation is quite robust to different dependence assumptions, the inference of PC loadings requires careful attention. We initiate and conclude our investigation with an empirical example on portfolio management, in which the PC loadings play a prominent role. It is given as a paradigm of correct usage of PCA for time series data.
Association between self‐reported oral disease/conditions and symptoms of depression among Iraqi individuals
Authors: Ahmed Alaa F , Naser Reyam J , Gul Sarhang S. , Abdulkareem Ali A. 
Published: January 2022

AbstractAimsThe negative impact of oral diseases on the function, economy, and general health of the population is well‐documented. In the last decades, evidence linking increased expression of depression and oral diseases/conditions has significantly increased. The aim of this study is to assess the association between oral disease/conditions and self‐reported symptoms of depression individuals.MethodsA specially designed questionnaire was distributed via social media for 1 week. It consisted of two main sections; the first section was dedicated to collect demographic variables and self‐reported symptoms of oral diseases. The second section, Patient Health Questionnaire‐9 (PHQ‐9), was used to assess the severity of depression via nine questions using a 4‐point Likert scale. Association between depression and oral disease was determined by linear regression analysis.ResultsA total of 1975 participants responded fully to the questionnaire and were included in the final analysis. The majority of participants, about 60%, showed mild to moderate symptoms of depression, while 8.9% expressed severe symptoms. Oral diseases positively associated with depression were caries, missing teeth, gingival bleeding, gingival recession, teeth mobility, and dry mouth (R2 = .155). In contrast, increased esthetic level of teeth/gingiva significantly decreased the feeling of depression.ConclusionsResults indicated that oral diseases, particularly those adversely affecting function and esthetics, were associated with symptoms of depression in Iraqi individuals. These findings highlighted the importance of maintaining oral health as part of the general psychological wellbeing of the population.
A new localized inverse identification method for high temperature testing under resistive heating: Application to the elastic‐viscoplastic behaviour of L‐PBF processed In718
Authors: Gao Feng , Macquaire Bruno , Zhang Yancheng , Bellet Michel 
Published: January 2022

AbstractThe mechanical behaviour of the nickel‐based superalloy In718, as processed from laser powder bed fusion (L‐PBF) additive manufacturing, is characterized at high temperature, from 800 to 1100°C. Samples built by L‐PBF are submitted to sequences combining uniaxial tensile load at different prescribed velocities, and relaxation steps of different durations, operated under resistive heating under vacuum, with a home‐developed testing machine. Tests are equipped with force evolution measurement, with infra‐red field imaging and thermocouples to capture the non‐uniform temperature distributions induced by resistive heating, and with digital image correlation to capture the non‐linear displacement fields. An inverse finite element strategy is developed to identify the parameters of a temperature‐dependent elastic‐viscoplastic behaviour model. The strategy is based on (i) direct finite element simulations of tests, (ii) a cost function expressing the distance between calculated and measured quantities, and (iii) a minimization algorithm. Direct numerical simulations are performed on a limited part of the working zone of samples, the zone of interest, with applied boundary conditions provided by DIC records and with an imposed temperature distribution provided by infra‐red imaging. The cost function is based on the force evolution only, for a series of different tests operated at different nominal temperatures. Optimum values of constitutive parameters are obtained by minimizing the cost function value, which is achieved with the home‐developed optimization platform MOOPI. Finally, the identified parameters are discussed with respect to the literature.
Alternative splicing of CsJAZ1 negatively regulates flavan‐3‐ol biosynthesis in tea plants
Authors: Zhu Junyan , Yan Xiaomei , Liu Shengrui , Xia Xiaobo , An Yanlin , Xu Qingshan , Zhao Shiqi , Liu Lu , Guo Rui , Zhang Zhaoliang , Xie De‐Yu , Wei Chaoling 
Published: January 2022

SUMMARYFlavan‐3‐ols are abundant in the tea plant (Camellia sinensis) and confer tea with flavor and health benefits. We recently found that alternative splicing of genes is likely involved in the regulation of flavan‐3‐ol biosynthesis; however, the underlying regulatory mechanisms remain unknown. Here, we integrated metabolomics and transcriptomics to construct metabolite–gene networks in tea leaves, collected over five different months and from five spatial positions, and found positive correlations between endogenous jasmonic acid (JA), flavan‐3‐ols, and numerous transcripts. Transcriptome mining further identified CsJAZ1, which is negatively associated with flavan‐3‐ols formation and has three CsJAZ1 transcripts, one full‐length (CsJAZ1‐1), and two splice variants (CsJAZ1‐2 and ‐3) that lacked 3′ coding sequences, with CsJAZ1‐3 also lacking the coding region for the Jas domain. Confocal microscopy showed that CsJAZ1‐1 was localized to the nucleus, while CsJAZ1‐2 and CsJAZ1‐3 were present in both the nucleus and the cytosol. In the absence of JA, CsJAZ1‐1 was bound to CsMYC2, a positive regulator of flavan‐3‐ol biosynthesis; CsJAZ1‐2 functioned as an alternative enhancer of CsJAZ1‐1 and an antagonist of CsJAZ1‐1 in binding to CsMYC2; and CsJAZ1‐3 did not interact with CsMYC2. In the presence of JA, CsJAZ1‐3 interacted with CsJAZ1‐1 and CsJAZ1‐2 to form heterodimers that stabilized the CsJAZ1‐1–CsMYC2 and CsJAZ1‐2–CsMYC2 complexes, thereby repressing the transcription of four genes that act late in the flavan‐3‐ol biosynthetic pathway. These data indicate that the alternative splicing variants of CsJAZ1 coordinately regulate flavan‐3‐ol biosynthesis in the tea plant and improve our understanding of JA‐mediated flavan‐3‐ol biosynthesis.