bluuebunny/crossref_metadata_2025_split huggingface dataset:
An improved approach based on dynamic mixed sampling and transfer learning for topic recognition: a case study on online patient reviews
Authors: Xie Yaotan , Xiang Fei 
Published: January 2022

PurposeThis study aimed to adapt existing text-mining techniques and propose a novel topic recognition approach for textual patient reviews.Design/methodology/approachThe authors first transformed multilabel samples for adapting model training forms. Then, an improved method was proposed based on dynamic mixed sampling and transfer learning to improve the learning problem caused by imbalanced samples. Specifically, the training of our model was based on the framework of a convolutional neural network and self-trained Word2Vector on large-scale corpora.FindingsCompared with the SVM and other CNN-based models, the CNN+ DMS + TL model proposed in this study has made significant improvement in F1 score.Originality/valueThe improved methods based on dynamic mixed sampling and transfer learning can adequately manage the learning problem caused by the skewed distribution of samples and achieve the effective and automatic topic recognition of textual patient reviews.Peer reviewThe peer-review history for this article is available at: https://publons.com/publon/10.1108/OIR-01-2021-0059.
An intelligent system for reflow oven temperature settings based on hybrid physics-machine learning model
Authors: Lai Yangyang , Pan Ke , Cen Yuqiao , Yang Junbo , Cai Chongyang , Yin Pengcheng , Park Seungbae 
Published: January 2022

Purpose
This paper aims to provide the proper preset temperatures of the convection reflow oven when reflowing a printed circuit board (PCB) assembly with varied sizes of components simultaneously.

Design/methodology/approach
In this study, computational fluid dynamics modeling is used to simulate the reflow soldering process. The training data provided to the machine learning (ML) model is generated from a programmed system based on the physics model. Support vector regression and an artificial neural network are used to validate the accuracy of ML models.

Findings
Integrated physical and ML models synergistically can accurately predict reflow profiles of solder joints and alleviate the expense of repeated trials. Using this system, the reflow oven temperature settings to achieve the desired reflow profile can be obtained at substantially reduced computation cost.

Practical implications
The prediction of the reflow profile subjected to varied temperature settings of the reflow oven is beneficial to process engineers when reflowing bulky components. The study of reflowing a new PCB assembly can be started at the early stage of board design with no need for a physical profiling board prototype.

Originality/value
This study provides a smart solution to determine the optimal preset temperatures of the reflow oven, which is usually relied on experience. The hybrid physics–ML model providing accurate prediction with the significantly reduced expense is used in this application for the first time.
Microsoft Teams and team performance in the COVID-19 pandemic within an NHS Trust Community Service in North-West England
Authors: Hargreaves Christopher , Clarke Andrew Paul , Lester Karl Robert 
Published: January 2022

Purpose
This study aims to evaluate the impact the introduction of Microsoft Teams has had on team performance in response to the COVID-19 pandemic within a National Health Service (NHS) Community Service.

Design/methodology/approach
Microsoft Teams was rolled out across the NHS over a period of four days, partly in response to the need for social distancing. This case study reviews how becoming a virtual team affected team performance, the role Microsoft Teams had played in supporting staff to work in higher virtuality, understand what elements underpin a successful virtual team and how these results correlate to the technology acceptance model (Davis, 1985).

Findings
The findings indicate that Teams made a positive impact to the team at a time of heightened clinical pressures and working in unfamiliar environments without the supportive benefits of face-to-face contact with colleagues in terms of incidental knowledge sharing and health and well-being.

Originality/value
Further developments were needed to make virtual meetings more accessible for introverted colleagues, support asynchronous communication, address training needs and support leaders to adapt and operate in higher virtuality.
Transferring knowledge and innovations through village knowledge center in Tanzania: approaches, impact and impediments
Authors: Mwantimwa Kelefa , Ndege Nora 
Published: January 2022

Purpose
Farmers in rural areas are generally not well empowered with knowledge and innovations to solve their agricultural problems in spite of the growing presence of such knowledge resulting from research and innovation activities across the globe. This study aims to document approaches, impact and impediments of using village knowledge centers (VKCs) to transfer agricultural knowledge and innovations.

Design/methodology/approach
To achieve the objective of the study, a case study research design was used to investigate the impact of a selected VKC as institutional innovation in agricultural technology outreach and extension in rural Tanzania. Primary data was collected through semi-structured interviews, focus group discussions and observation methods. Besides, secondary sources such as reports were used to complement primary data during fieldwork.

Findings
The study reveals that various approaches are used by the VKC to transfer knowledge and innovation to farmers. The use of the multi-actor platform (MAP) to run the VKC ensures inclusive knowledge production and sharing among different actors. The findings also suggest that knowledge and innovation co-creation is constructed with various knowledge systems actors to enhance the use of research generated. Accordingly, the findings show that the university efforts are an important catalyst for integrated knowledge, technology and innovation systems in rural settings.

Research limitations/implications
The present study reveals different limitations associated with the use of a single case study design. The single-case design provided researchers with little basis for generalisation of the study findings and conclusions. Aside from that, the use of a cross-sectional design did not help the researchers to validate the findings and conclusions. To address these limitations, the study recommends similar studies that will adopt different types of longitudinal design such as cohort and diary methods. Apart from this, a future study to investigate the tangible impact of VKC on knowledge and innovation transfer is recommended.

Originality/value
Considering the novelty of the MAP approach in Tanzania and the dearth of studies reporting on how the village knowledge center works and how effective it is, the present study provides insights on the approaches, impact and impediments.
Highly efficient rDNA‐mediated multicopy integration based on the dynamic balance of rDNA in Saccharomyces cerevisiae
Authors: Zheng Huihui , Wang Kai , Xu Xiaoxiao , Pan Jing , Sun Xinhua , Hou Jin , Liu Weifeng , Shen Yu 
Published: January 2022

SummaryEngineered Saccharomyces cerevisiae strains are good cell factories, and developing additional genetic manipulation tools will accelerate construction of metabolically engineered strains. Highly repetitive rDNA sequence is one of two main sites typically used for multicopy integration of genes. Here, we developed a simple and high‐efficiency strategy for rDNA‐mediated multicopy gene integration based on the dynamic balance of rDNA in S. cerevisiae. rDNA copy number was decreased by pre‐treatment with hydroxyurea (HU). Then, heterologous genes were integrated into the rDNA sequence. The copy number of the integrated heterologous genes increased along with restoration of the copy number of rDNA. Our results demonstrated that HU pre‐treatment doubled the number of integrated gene copies; moreover, compared with removing HU stress during transformation, removing HU stress after selection of transformants had a higher probability of resulting in transformants with high‐copy integrated genes. Finally, we integrated 18.0 copies of the xylose isomerase gene into the S. cerevisiae genome in a single step. This novel rDNA‐mediated multicopy genome integration strategy provides a convenient and efficient tool for further metabolic engineering of S. cerevisiae.
Local ablative radiotherapy on oligo‐progression while continued on epidermal growth factor receptor tyrosine kinase inhibitors in advanced non–small cell lung cancer patients: A longer cohort
Authors: Mok Florence Siu ting , Tong Macy , Loong Herbert H. , Mok Tony S. K. 
Published: January 2022

AbstractBackgroundThe effect of adding local ablative radiotherapy on oligo‐progression while continuing EGFR‐TKIs in advanced non–small cell Lung cancer (NSCLC) patients is to be determined.MethodsOutcomes of patients with stage IV NSCLC harboring EGFR‐activating mutations having ≤5 sites of oligo‐progression while on EGFR‐TKIs and given one to eight fractions of local ablative radiotherapy (LAR) were reviewed from 2012 to 2019. The time of starting first‐line EGFR‐TKIs to LAR is defined as progression‐free survival 1 (PFS1; > one line of prior treatment allowed). The primary endpoint was PFS from LAR to further progression that led to stop of EGFR‐TKIs (PFS2). The secondary endpoint was overall survival from LAR (OS). Factors affecting PFS2 and OS were analyzed with Cox regression.ResultsThere were total 55 eligible patients. The median follow‐up time was 13.3 months. Majority (89%) had sensitive mutations (exon 19 deletion and exon 21 L858R mutation). Total number of lesions treated were 75, including lung (n = 45), bone (n = 15), cervical lymph node (n = 1), adrenal (n = 1), and brain (n = 13). The median PFS2 was 6.9 months. The median OS was 25.1 months. On multivariable analysis, it was found that EGFR mutation type (exon 19 deletion / exon 21 L858R mutation vs. other rarer mutations), time from diagnosis to LAR within 70 days, and fewer lines of prior TKIs (1 or 2 vs. 3) had favorable effect on PFS2 (p = 0.006/0.00003; 0.046; 0.001/0.005, respectively).ConclusionLAR is a noninvasive and effective modality in treatment of oligo‐progressive diseases for patients with EGFR mutations positive NSCLC while on EGFR‐TKIs.
A national survey of oncology physiotherapy services for cancer survivors in Australia
Authors: Shipton Daniel A. , Dennett Amy M. , Sayner Alesha M. , Tang Clarice Y. 
Published: January 2022

AbstractBackgroundCancer is a leading cause of illness globally. Advancements in screening and treatment have led to improved survivorship. Physiotherapy is integral in improving survivorship for people with cancer, with strong evidence supporting the use of various physiotherapy services. However, the scope and extent of these services within clinical practice in Australia is unknown.AimIdentify and describe physiotherapy service provision for cancer survivors in Australia and describe the scope of physiotherapy services provided to cancer survivors.MethodsThis cross‐sectional study recruited physiotherapists and their respective managers involved in cancer service/s provision across Australia. Physiotherapy departments of tertiary hospitals and known oncology rehabilitation programs were contacted through a government directory and snowball sampling. The online survey included questions related to the extent and scope of service provision of physiotherapy for cancer survivors. Quantitative data were descriptively analyzed whereas open‐ended responses were analyzed and presented narratively.ResultsSeventy‐nine physiotherapy services were identified from 159 hospitals and/or health networks. Of the 55 (70%) responses received, 87% were from metropolitan areas, whereas 13% were regionally/rurally based services. Prehabilitation services mostly offered individual programs whereas rehabilitation programs had a mix of individual and group‐based programs. The service content between prehabilitation and rehabilitation were similar, comprising primarily exercise‐based interventions, followed by education and impairment‐based therapies.ConclusionFew designated physiotherapy services for cancer survivors exist in Australia. There is also disparity between service provision between metropolitan and regional/rural areas highlighting a need for clinicians, managers, and policy makers to invest more resources in establishing oncology physiotherapy services.
Clinical and genetic characteristics of early‐stage multiple primary and independent primary lung adenocarcinoma patients
Authors: Li Peng , Yang Ronghua , Wang Dong , Wang Lingjie , Wang Sai , Liu Chuan , Li Jinlong , Li Ling , Liu Chuang , Tong Yan , Wang Yongjie 
Published: January 2022

AbstractAimsThe difference between multiple primary lung cancers (MPLC) and intrapulmonary metastasis (IM) in patients with lung cancer is vital but controversial. Moreover, the genetic and clinical significance difference between MPLC and independent primary lung cancers (IPLC) patients is unknown.MethodsThis study retrospectively researched clinical and genetic data of MPLC and IPLC patients from January 2019 to May 2021 at the affiliated hospital of Qingdao University, China. Ninety‐four tissue samples from 41 early‐stage patients with MPLC, and 94 tissue samples from 94 early‐stage patients with IPLC were performed to targeted sequencing.ResultsA total of 36 patients (88%) showed inconsistent driver mutations, and five MPLC patients (12%) shared single identical EGFR/BRAF/TP53 hotspot mutations in the early stage. In MPLC patients, high‐frequency mutations included EGFR (63%), TP53 (12%), BRAF (12%), KRAS (10%), ERBB2 (4%), PIK3CA (3%), and MET (3%). In IPLC patients, high‐frequency mutations included EGFR (55%), TP53(26%), KRAS (13%), MAP2K1 (5%), PIK3CA (4%), ERBB2 (4%), NF1 (4%), RET (3%), and BRAF (2%). The higher BRAF and fewer TP53 mutations may be related to the lower malignancy in MPLC patients.ConclusionsThe accuracy of pathological diagnosis in patients with early‐stage MPLC does not need comprehensive molecular evaluation to supplement histology for differentiating early‐stage MPLC and IM. Meanwhile, the molecular difference between MPLC and IPLC may be helpful to study the mechanism of MPLC pathogenesis.
Tripartite motif‐containing 54 promotes gastric cancer progression by upregulating K63‐linked ubiquitination of filamin C
Authors: Cao Hongtao , Li Ye , Chen Liang , Lu Zhuocai , You Tian , Wang Xiaolong , Ji Baoyan 
Published: January 2022

AbstractBackgroundTripartite motif (TRIM) proteins have been proved to contribute to cancer progression, while whether tripartite motif‐containing 54 (TRIM54) could functionally influence gastric cancer (GC) progression remains elusive.MethodsThe expression level of TRIM54 and filamin C (FLNC) in GC was determined by Western blot and online database. Cell Counting Kit‐8 (CCK‐8) assay, colony formation assay and Ethylenediurea (EdU) staining were performed to explore the effects of TRIM54 on GC cell proliferation. Transwell assay and wound healing assay were applied to detect the influence of TRIM54 on GC cell migration and invasion. Bioinformatics analysis and Co‐immunoprecipitation assay (Co‐Ip), Ubiquitination assay and Half‐life assay were involved to explore the regulatory mechanism of TRIM54 on FLNC.ResultsTRIM54 was upregulated in GC tissues and cells, and a higher expression level of TRIM54 indicated a shorter overall survival of GC patients. The overexpression of TRIM54 significantly enhanced proliferation, migration, and invasion of GC cells, and inhibition of TRIM54 expression exerted reverse effects on GC cells. Mechanistically, TRIM54 was determined as a post‐translational mediator of FLNC, and TRIM54 was co‐immunoprecipitated with FLNC and degraded its protein level via K63‐linked ubiquitination of FLNC. Notably, FLNC efficiently inhibited GC progression by TRIM54 overexpression.ConclusionCollectively, our findings suggested that the TRIM54/FLNC axis could be considered as a potential prognostic biomarker for GC.
Transitional changes of spacer materials used in carbon‐ion radiation therapy
Authors: Yamamoto Yayoi , Hino Ayako , Kurihara Hiroaki , Kano Kio , Serizawa Itsuko , Katoh Hiroyuki , Hiruma Toru 
Published: January 2022

AbstractPurposeTo evaluate the imaging findings and transitional changes in spacer materials used in carbon‐ion radiation therapyMaterialsMedical records were retrospectively reviewed, and the maximum thickness, volume, and CT value of spacers were calculated from CT scans. Procedure‐related complications were recorded.ResultsA spacer was surgically placed in six patients in retroperitoneal, presacral, or peritoneal sites. The spacer material was polyglycolic acid (PGA) in four patients and expanded polytetrafluoroethylene (ePTFE) in two patients. The thickness of PGA spacers showed no changes in any patients within 4 weeks, but increased within 6 weeks in one patient and was unchanged or decreased in the remaining patients. PGA spacer volume decreased gradually after placement in three of four patients; this was observed at 4 months in two patients and at 6 months in one patient. The mean CT value of PGA spacers was 83 HU just after placement, and decreased gradually thereafter. Air was seen in the PGA spacers of two patients. Neither ePTFE spacer showed volume changes over time, and the mean CT value was low (mean, –53.7 HU) just after placement but increased rapidly to 145 HU at 2 months.ConclusionSpacer imaging findings may vary according to type and may change over time. Familiarity with these features is beneficial for diagnostic radiologists.
Historical Consciousness, Part I: Origins and Characteristics
Authors: Cobb John B. 
Published: January 2022

AbstractAlthough history as a scientific discipline continues to be taught in universities, historical consciousness is being displaced in modern self‐understanding by scientific rationality. There is no necessary conflict between the two. Each is a form of critical understanding, and each benefits from the work of the other. But whereas modern intellectuals perceive the value of analyzing events outside of time and history in purely formal or mathematical terms, the value of understanding the place of events in the larger patterns of history is losing ground. A likely cause of this loss is the decline in intellectual respect for the roots of historical consciousness in the prophetic tradition found in the Hebrew Bible. No other culture in the ancient world focused attention on questions that related personal and collective behavior to the larger context of universal history. As recognition of that remarkable human achievement slowly dissolves in modern awareness, we are losing the capacity to question the wisdom of geopolitical, environmental, and technological changes taking place with long‐term consequences. In a word, we are losing perspective. This is an almost completely invisible feature of the wholesale rejection of the Bible as a source of self‐understanding.
Biblical Sabbath as Critical Response in an Era of Global Pandemic and Climate Change
Authors: Lowery Richard H. 
Published: January 2022

AbstractIn modern times, the idea of the sabbath is often limited to a day when people attend religious services or observe rituals in their homes. Biblical sabbath, however, is one of the first codifications of labor rights in world history. This tradition emerged in an ancient economy that extracted agricultural wealth from subsistence farmers to support wealthy elites. Increasing demands on labor were coupled with reductions in the amount of produce available to individual households for sustenance. This led to impoverishment and to interest lending that often resulted in the loss of ancestral property and debt servitude to wealthy creditors. Sabbath traditions, both a weekly day of rest and periodic cancellation of debt, were attempts to mitigate the negative impact of this royal‐imperial system. Those traditions functioned as a critique and a corrective to the royal‐imperial economy. These traditions still have conceptual and practical utility for today’s globalizing economy that is challenged by climate change and reshaped by the COVID pandemic. “Sabbath economics” is built on a notion of abundance limited by self‐restraint—seven days of wealth for six days of work. This model overturns modern assumptions of scarcity and unlimited needs and wants. The values expressed in this ancient tradition can help us imagine the role of work and rest in a just and ecologically sustainable future.
Commitment Problems in Alliance Formation
Authors: Benson Brett V. , Smith Bradley C. 
Published: January 2022

AbstractIf military alliances cause significant shifts in the distribution of power, why does anticipation of their formation or expansion provoke hostility from adversaries in some cases and not others? We develop a theory to explain this variation, advancing three arguments about the connection between alliances, commitment problems and war. First, we show that prospective allies can avoid provoking a common enemy by offering concessions to offset losses from an anticipated power shift from an alliance. Second, limits to an alliance's power or implementation speed may make such bargains possible. Allies manipulate these factors to set the terms of cooperation to avoid provoking a shared enemy. Finally, when such bargains are not possible, incentives for preventive war exist but the outbreak of such wars may be avoided. Although preventive war cannot be ruled out altogether, the conditions that make it most attractive also make it unlikely to be carried out.
Distinct environmental cues trigger spontaneous recall of past events in 3‐ and 4‐year‐old children even after long delays
Authors: Jensen Toril S. , Berntsen Dorthe , Kingo Osman S. , Krøjgaard Peter 
Published: January 2022

AbstractVerbally reported long‐term memory for past events typically improves with age. However, such findings are based exclusively on studies, where children are directly asked to recall. The present study showed that when 3‐ (n = 113, 59 girls) and 4‐year‐olds (n = 113, 62 girls), predominantly White, were brought back to a distinct laboratory‐setting after either 1‐, 4.5‐, or 13‐weeks, children—regardless of age and delay—spontaneously recalled the distinct event experienced at their first visit (all Cohen'sds > 1.00). Meanwhile, the oldest children outperformed the youngest when being asked directly to retrieve the event (). These findings suggest that spontaneous retrieval facilitated by distinct environmental cues provides a short‐cut to young children's event memories.