bluuebunny/crossref_metadata_2025_split huggingface dataset:
PELATIHAN MENULIS PROCEDURE TEXT DENGAN MENGGUNAKAN APLIKASI PADLET DI ENGLISH CONVERSATION CLUB MAN KOTA BLITAR
Authors: Fadhilawati Dian , Mansur Moh 
Published: June 2022

Pengabdian masyarakat ini bertujuan untuk meningkatkan keterampilan menulis procedure text Siswa ECC MAN Kota Blitar yang masih kurang dengan melalui aplikasi Padlet. Pelatihan ini dilaksanakan setiap hari Jumat dari 5 maret sampai 9 April 2021. Dikarenakn pandemic Covid 19 masih melanda yang tidak memungkinkan pelatih melakukan pelatihan secara langsung ke sekolah maka pelatihan ini dilaksanakan dengan virtual menggunakam aplikasi Padlet. Lebih lanjut, sebagai komunikasi kita menggunakan group WhatsApp khusus untuk ECC MAN Kota Blitar. Pelatihan ini diikuti oleh 25 siswa dengan prosedur: Pre-test, Pengenalan Aplikasi Padlet ke siswa, Pembelajaran Procedure Text melalui Aplikasi Padlet, Praktek Menulis Procedure text, dan diakhiri dengan post-test. Hasil pelatihan ini telah mampu meningkatkan kemampuan menulis procedure text siswa dari 62.90 ke 81.35. Dari hasil tersebut, pelatih menyarankan agar siswa terus untuk berlatih menulis dalam Bahasa inggris melalui aplikasi Padlet tidak terbatas pada menulis procedure text tapi juga menulis dengan topik lain misalnya menulis kegiatan sehari hari mereka dengan menggunakan Bahasa Inggris di Aplikasi Padlet.
PEMBERDAYAAN KOMUNITAS PENGEMBANG PANGAN LOKAL KABUPATEN NGANJUK MELALUI PENGEMBANGAN PRODUK PIE SUSU HERBAL
Authors: Yulistiani Ratna , Winarti Sri , Ramadhany Arlita , Pramudita Mardani Rizkia 
Published: June 2022

Komunitas Pengembang Pangan Lokal (KPPL) Desa Banjaranyar, Kecamatan Tanjunganom, Kabupaten Nganjuk memiliki keinginan besar untuk memberdayakan komoditas lokal menjadi produk unggulan daerah yang memiliki nilai ekonomi dan daya saing tinggi. Salah satu produk yang akan dikembangkan adalah produk “Pie Susu Herbal” dengan beberapa varian rasa yang mengandung komponen bioaktif, yang berperan dalam peningkatan sistem kekebalan tubuh di masa pandemi Covid-19. Komunitas ini memiliki keinginan yang tinggi untuk maju, namun memiliki keterbatasan di bidang teknologi, oleh sebab itu tim dari UPN Veteran Jawa Timur mengimplementasikan kegiatan pelatihan pengolahan produk pie susu herbal yang memiliki peluang pasar tinggi, yang nantinya diharapkan sebagai produk unggulan Kabupaten Nganjuk. Adapun metode yang telah dilakukan, antara lain : 1). pelatihan pengembangan produk Pie Susu Herbal (materi pelatihan : teknik pembuatan Pie Susu Herbal dengan aneka varian, pengemasan dan pelabelan pangan, analisis ekonomi dan strategi pemasaran) ; 2). pemberian bantuan peralatan produksi; 3) Pendampingan keberlanjutan kegiatan usaha dan pemasaran hasil produksi; 5). Monitoring dan evaluasi hasil kegiatan. Hasil dari kegiatan ini antara lain: 1). meningkatkan keterampilan anggota KPPL dalam memproduksi Pie Susu Herbal dengan aneka varian ; 2). Terciptanya produk Pie Susu Herbal dengan tiga varian rasa (pie susu panjare, pie susu rosela dan pie susu jaelang) dalam kemasan yang menarik dan sudah mulai dipasarkan; 3). Terbukanya peluang berwirausaha Pie Susu Herbal dengan aneka varian yang diharapkan menjadi ikon makanan khas Kabupaten Nganjuk. Hasil dari kegiatan ini diharapkan dapat mengembangkan potensi sumber daya alam menjadi produk unggulan Kota Nganjuk, disukai masyarakat dan memiliki peluang untuk dipasarkan ke berbagai daerah sehingga dapat meningkatkan perekonomian masyarakat.
PELATIHAN DAN SOSIALISASI APLIKASI E-LEARNING EDMODO PADA MASA PANDEMI COVID-19 DI SMPN 1 NDONA
Authors: Siahaan Desta Gloria , Pardosi Lukas 
Published: June 2022

Pemanfaatan media teknologi informasi dan komunikasi telah merambah ke semua bidang kehidupan. Salah satu pemanfaatan media teknologi informasi dan komunikasi di bidang pendidikan adalah e-learning. E-learning (electronic learning) merupakan proses pembelajaran yang memanfaatkan teknologi informasi dalam hal ini memanfaatkan media online seperti internet sebagai metode penyampaian, interaksi dan fasilitasi. Pemanfaatan platform e-learning dapat mempermudah guru dan siswa dalam proses pembelajaran. Tujuan pelaksanaan kegiatan ini adalah Pertama, memberikan konsep dan sosialiasi pemanfaatan Edmodo untuk proses pembelajaran. Kedua, memberikan pengetahuan tentang bagaimana cara menggunakan dan mengaplikasikan fitur-fitur yang terdapat dalam platform edmodo untuk memudahkan proses pembelajaran. Target untuk pengabdian ini adalah guru-guru di SMP Negeri 1 Ndona, Ende. Pengabdian ini diharapkan mampu memberikan skill tambahan bagi guru-guru bagaimana memanfaatkan platform e-learning (edmodo) secara gratis untuk mensuport pembelajaran konvensional di masa pandemi covid-19 ini.
LA EDUCACIÓN MEDIADA POR LAS TECNOLOGÍAS DURANTE LA PANDEMIA POR COVID-19, DESDE LA MIRADA DE LOS ESTUDIANTES: APRENDIZAJES Y EXPERIENCIAS
Authors: Andrade-Cázares Rocío Adela , Carpio-Domínguez Rosa Evelia , Sánchez-Luna Marina 
Published: June 2022

El presente trabajo da cuenta de cómo se ha vivido el proceso de pandemia de COVID-19, por estudiantes de licenciatura de cuatro contextos educativos distintos, en donde se invita a participar a estudiantes de educación, psicología educativa y de la carrera deBiología. Se analiza el proceso de aprendizaje en el contexto de la pandemia por COVID-19 y cuáles son las experiencias que rescatan los estudiantes mediante el proceso de aprender en la virtualidad usando como medio las Tecnologías de la Información y la Comunicación (TIC). El método de investigación es de tipo mixto, se hace un análisis de los datos de tipo cuantitativo y cualitativo. Los resultados dan cuenta de cómo se vivió la educación en época de pandemia desde el confnamiento en México.
Palabras claveEstudiantes, experiencias educativas, pandemia, TIC, virtualidad.
AbstractThis paper narrates how the pandemic process of COVID-19 has been experienced by undergraduate students from four diferent educational contexts, where students of education, educational psychology and biology were invited to participate. The studyanalyzed the learning process in the context of the pandemic caused by COVID-19 and the experiences that students rescued through the process of learning in virtuality by using Information and Communication Technologies (ICT). The research method is of a mixed type, an analysis of quantitative and qualitative data was carried out. The results show how education was lived in times of pandemic during the confnement in Mexico.
KeywordsStudents, educational experiences, pandemic, ICT, virtuality
Avaliação da atividade gastroprotetora do extrato etanolico e do extrato hexânico dos resíduos dos frutos de Spondias mombin L.
Authors: Cartaxo Higor Braga , Alves Maria Rayane Teodósio , Silva Danielle Rocha , Lucena Gislayne Tacyana Santos , Brito Samara Alves 
Published: June 2022

A úlcera péptica é uma lesão inflamatória na mucosa gástrica. É ocasionada tanto pelo desequilíbrio entre os fatores que danificam a mucosa com os que a protegem onde os que danificam sobressaem. Spondias mombin L. (Anacardiaceae), conhecida popularmente como cajazeiras, é utilizada na medicina popular para o tratamento de diversas doenças como a conjuntivite, ação cicatrizante, antidiarréico, diurético, dentre outras. Algumas atividades farmacológicas já foram comprovadas para a espécie, como atividade gastroprotetora, anti-inflamatório e antibacteriano. O objetivo desse estudo foi comparar o efeito gastroprotetor entre o extrato etanolico e o extrato hexanico dos resíduos de frutos de S. mombin L. Para isso, o resíduo dos frutos foi obtido por doação da associação de produtores rurais de frutas do boqueirão- Cajazeiras- PB. Em seguida o material foi seco e triturado. Os extratos etanolico e hexanico foram obtidos separadamente por maceração. A atividade gastroprotetora foi realizada em ratos (n=5) pelo método de indução da lesão gástrica com etanol. As doses para o extrato etanolico foram 100 e 200 mg/kg e para o extrato hexanico, uma dose de 100 mg/kg. Como controle positivo foi utilizado omeprazol (30 mg/kg) e para o controle negativo foi utilizado Na Cl 0,9%. O resultado obtido neste trabalho mostrou uma capacidade gastroprotetora do extrato hexanico dos resíduos do cajá em 89.46% quando comparado ao grupo controle. Pode-se concluir que os compostos apolares foram eficazes quando comparados aos compostos polares.
A Novel Salt-Bridge Electroflocculation Technology for Harvesting Microalgae
Authors: Hou Yuyong , Liu Chenfeng , Liu Zhiyong , Han Tong , Hao Nahui , Guo Zhile , Wang Weijie , Chen Shulin , Zhao Lei , Safavi Maliheh , Ji Xiang , Chen Fangjian 
Published: June 2022

Microalgae biomass, as a promising alternative feedstock, can be refined into biodiesel, pharmaceutical, and food productions. However, the harvesting process for quality biomass still remains a main bottleneck due to its high energy demand. In this study, a novel technique integrating alkali-induced flocculation and electrolysis, named salt-bridge electroflocculation (SBEF) with non-sacrificial carbon electrodes is developed to promote recovery efficiency and cost savings. The results show that the energy consumption decreased to 1.50 Wh/g biomass with a high harvesting efficiency of 90.4% under 300 mA in 45 min. The mean particle size of algae flocs increased 3.85-fold from 2.75 to 10.59 µm, which was convenient to the follow-up processing. Another major advantage of this method is that the salt-bridge firmly prevented cells being destroyed by the anode’s oxidation and did not bring any external contaminants to algal biomass and flocculated medium, which conquered the technical defects in electro-flocculation. The proposed SBEF technology could be used as a low cost process for efficient microalgae harvest with high quality biomass.
Assessing Wave Attenuation With Rising Sea Levels for Sustainable Oyster Reef-Based Living Shorelines
Authors: Salatin Reza , Wang Hongqing , Chen Qin , Zhu Ling 
Published: June 2022

In densely populated coastal areas with sea-level rise (SLR), protecting the shorelines against erosion due to the wave impact is crucial. Along with many engineered structures like seawalls and breakwaters, there are also green structures like constructed oyster reefs (CORs) that can not only attenuate the incident waves but also grow and maintain pace with SLR. However, there is a lack of data and understanding of the long-term wave attenuation capacity of the living shoreline structures under SLR. In this study, we used the phase-resolving Boussinesq model, FUNWAVE-TVD, to examine the hydrodynamics including wave height and wave-induced currents around the CORs in the Gandys Beach living shoreline project area in the upper Delaware Bay, United States. Waves were measured at six locations (offshore to onshore, with and without CORs) in the Gandys Beach living shoreline project area for two winter months, during which four nor’easters occurred. We selected three cases that represent prevailing wind, wave, and tide conditions to examine the fine spatial and temporal changes in wave height and current velocity by the construction of the reefs. Wave heights and wave energy spectra generated from FUNWAVE-TVD were then validated with field observations. It is found that FUNWAVE-TVD is capable of simulating waves and associated hydrodynamic processes that interact with CORs. The model results show that wave attenuation rates vary with the incident wave properties and water depth, and wave-induced circulation patterns are affected by the CORs. The wave attenuation capacity of CORs over the next 100 years was simulated with the incorporation of the oyster reef optimal growth zone. Our study found that sustainable wave attenuation capacity can only be achieved when suitable habitat for COR is provided, thus it can vertically grow with SLR. Suitable habitat includes optimal intertidal inundation duration, current velocity for larval transport and settlement, on-reef oyster survival and growth, and other environmental conditions including salinity, temperature, and nutrient availability. Furthermore, the model results suggest that it would take CORs approximately 9 years after construction to reach and maintain the maximum wave attenuation capacity in sustainable living shorelines.
Comprehensive Analysis of Gut Microbiota and Fecal Bile Acid Profiles in Children With Biliary Atresia
Authors: Yang Ting , Yang Shen , Zhao Jiawei , Wang Peize , Li Siqi , Jin Yuyan , Liu Zhaozhou , Zhang Xinyue , Zhang Yanan , Zhao Yong , Liao Junmin , Li Shuangshuang , Hua Kaiyun , Gu Yichao , Wang Dingding , Huang Jinshi 
Published: June 2022

BackgroundBiliary atresia (BA) is the most common cholestatic liver disease in neonates. Herein, we aimed at characterizing the gut microbiota and fecal bile acid profiles of BA patients, defining the correlations between them, and evaluating the relationship between the clinical pathogenesis and changes in the gut microbiota and bile acid profiles.MethodsA total of 84 fecal samples from BA patients (n = 46) and matched healthy controls (HCs, n = 38) were subjected to sequencing by 16S rRNA gene amplification, and fecal bile acid were analyzed by targeted metabolomics.FindingsCompared with the controls, a structural separation of the intestinal flora of BA patients was uncovered, which was accompanied by changes in the composition of fecal bile acids. In the BA group, Actinobacillus, Monoglobus, and Agathobacter were enriched in patients without cholangitis (p &lt; 0.05). Selenomonadaceae and Megamonas were more abundant in patients without recurrent cholangitis episodes (p &lt; 0.05), while Lachnospiraceae and Ruminococcaceae were enriched in patients with multiple recurrences of cholangitis (p &lt; 0.05). Postoperative jaundice clearance was associated with Campylobacter and Rikenellaceae (p &lt; 0.05), and tauroursodeoxycholic acid was associated with jaundice clearance (p &lt; 0.001).ConclusionBA patients are characterized by different compositions of gut microbiota and bile acids, and their interaction is involved in the process of liver damage in BA, which may be closely related to the occurrence of postoperative cholangitis and jaundice clearance.
The Association Between Remnant Cholesterol and the Estimated 10-Year Risk of a First Hard Cardiovascular Event
Authors: Yang Zhen , Yang Kuo , Shi Junhe , Yang Qiaoning , Zhang Ying , Gao Jie , Shi Dazhuo , Qu Hua 
Published: June 2022

BackgroundRemnant cholesterol (Remnant-C), rather than TG, is believed to increase the risk of atherosclerotic cardiovascular disease. We evaluated whether Remnant-C is associated with an estimated 10-year risk of a first hard atherosclerotic cardiovascular disease event.MethodsThis cross-sectional study was performed on 2,048 participants (1,130 men and 918 women), aged 40 to 79 years, from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. The independent variable was Remnant-C; the dependent variable was the 10-year risk of a first hard atherosclerotic cardiovascular disease event (defined as non-fatal myocardial infarction, coronary heart disease death, or stroke, over a 10-year period among people free from atherosclerotic cardiovascular disease at the beginning of the period). The other variables, such as smoking behavior, hypertension, diabetes etc., were considered as the potential effect modifiers. Multivariate linear regression models and smooth curve fittings were used to evaluate the association between Remnant-C and the 10-year risk of a first hard atherosclerotic cardiovascular disease event. Subgroup analyses stratified by gender and race were also performed.ResultsA positive association between Remnant-C and the 10-year risk of a first hard atherosclerotic cardiovascular disease event was demonstrated in the fully adjusted model (β = 0.078, [95%CI: 0.061–0.094], P &lt; 0.001). The 10-year risk was increased by 0.078% for each 1 mg/dl increase in Remnant-C. In the subgroup analysis for gender, this association remained in both men (β = 0.128, [95%CI: 0.108–0.148], P &lt; 0.001) and women (β = 0.043, [95%CI: 0.016–0.070], P = 0.00179). However, in the subgroup analysis for race, the association between Remnant-C and the 10-year risk reached an inflection point at remnant-C 38 mg/dL, where a positive association was not as obvious for the non-Hispanic Black population as for other racial groups.ConclusionsRemnant-C positively correlates with a 10-year risk of a first hard atherosclerotic cardiovascular disease event.
Electrocardiographic Markers Indicating Right Ventricular Outflow Tract Conduction Delay as a Predictor of Major Arrhythmic Events in Patients With Brugada Syndrome: A Systematic Review and Meta-Analysis
Authors: Iqbal Mohammad , Putra Iwan Cahyo Santosa , Pranata Raymond , Budiarso Michael Nathaniel , Pramudyo Miftah , Goenawan Hanna , Akbar Mohammad Rizki , Kartasasmita Arief Sjamsulaksan 
Published: June 2022

IntroductionRisk stratification in Brugada Syndrome (BrS) patients is still challenging due to the heterogeneity of clinical presentation; thus, some additional risk markers are needed. Several studies investigating the association between RVOT conduction delay sign on electrocardiography (ECG) and major arrhythmic events (MAE) in BrS patients showed inconclusive results. This meta-analysis aims to evaluate the association between RVOT conduction delay signs presented by aVR sign and large S wave in lead I, and MAE in BrS patients.MethodsThe literature search was performed using several online databases from the inception to March 16th, 2022. We included studies consisting of two main components, including ECG markers of RVOT conduction delay (aVR sign and large S wave in lead I) and MAE related to BrS (syncope/VT/VF/SCD/aborted SCD/appropriate ICD shocks)ResultsMeta-analysis of eleven cohort studies with a total of 2,575 participants showed RVOT conduction delay sign was significantly associated with MAE in BrS patients [RR = 1.87 (1.35, 2.58); p &lt; 0.001; I2= 52%, Pheterogeneity = 0.02]. Subgroup analysis showed that aVR sign [RR = 2.00 (1.42, 2.83); p &lt; 0.001; I2= 0%, Pheterogeneity = 0.40] and large S wave in lead I [RR = 1.74 (1.11, 2.71); p = 0.01; I2= 60%, Pheterogeneity = 0.01] were significantly associated with MAE. Summary receiver operating characteristics analysis revealed the aVR sign [AUC: 0.77 (0.73–0.80)] and large S wave in lead I [AUC: 0.69 (0.65–0.73)] were a good predictor of MAE in BrS patients.ConclusionRVOT conduction delay sign, presented by aVR sign and large S wave in the lead I, is significantly associated with an increased risk of MAE in BrS patients. Hence, we propose that these parameters may be useful as an additional risk stratification tool to predict MAE in BrS patients.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/#recordDetails, identifier: CRD42022321090.
Tolerability and Effectiveness of Switching to Dulaglutide in Patients With Type 2 Diabetes Inadequately Controlled With Insulin Therapy
Authors: Kim Youngsook , Huh Ji Hye , Lee Minyoung , Kang Eun Seok , Cha Bong-Soo , Lee Byung-Wan 
Published: June 2022

AimsGlucagon‐like peptide 1 (GLP-1) receptor agonists have demonstrated strong glycemic control. However, few studies have investigated the effects of switching from insulin to GLP-1 receptor agonists. We aimed to investigate, using real-world data, whether switching to dulaglutide improves glycemic control in patients with type 2 diabetes mellitus (T2D) inadequately controlled with conventional insulin treatment.Materials and methodsWe retrospectively evaluated 138 patients with T2D who were switched from insulin to dulaglutide therapy. We excluded 20 patients who dropped out during the follow-up period. The participants were divided into two groups according to whether they resumed insulin treatment at 6 months after switching to a GLP-1 receptor agonist (group I) or not (group II). A multiple logistic regression analysis was performed to evaluate the parameters associated with the risk of resuming insulin after replacement with dulaglutide.ResultsOf 118 patients initiated on the GLP-1 receptor agonist, 62 (53%) resumed insulin treatment (group I), and 53 (47%) continued with GLP-1 receptor agonists or switched to oral anti-hypoglycemic agents (group II). Older age, a higher insulin dose, and lower postprandial glucose levels while switching to the GLP-1 receptor agonist were associated with failure to switch to the GLP-1 receptor agonist from insulin.ConclusionsA considerable proportion of patients with T2D inadequately controlled with insulin treatment successfully switched to the GLP-1 receptor agonist. Younger age, a lower dose of insulin, and a higher baseline postprandial glucose level may be significant predictors of successful switching from insulin to GLP-1 receptor agonist therapy.
Homeostatic Model Assessment for Insulin Resistance Is Associated With Late Miscarriage in Non-Dyslipidemic Women Undergoing Fresh IVF/ICSI Embryo Transfer
Authors: Yang Tianli , Yang Yuanyuan , Zhang Qiong , Liu Donge , Liu Nenghui , Li Yumei , Yao Zhongyuan , Zhang Yeqing , Tian Fen , Zhao Jing , Li Yanping 
Published: June 2022

ObjectiveTo evaluate the associations between homeostatic model assessment for insulin resistance (HOMA-IR) and pregnancy outcomes in non-dyslipidemic infertile women undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET).Materials and MethodsThis is a retrospective study involving 3,615 non-dyslipidemic infertile women who attend to the Reproductive Medicine Center of Xiangya Hospital, Central South University (CSU) between January 2014 and October 2021. Eligible participants were divided into three groups according to the quartiles of HOMA-IR: Group 1 (HOMA-IR &lt;1.46), Group 2 (1.46 to &lt;2.71) and Group 3 (HOMA-IR ≥2.71). Baseline data, clinical characteristics during the assisted reproductive technology (ART) procedure, pregnancy, and neonatal outcomes were compared among the three groups. Subgroup analysis based on presence or absence of the polycystic ovary syndrome (PCOS) status was also performed to analyze the effects of HOMA-IR among non-PCOS populations.ResultsThe late miscarriage rate and percentage of macrosomia increased with the HOMA-IR group (for late miscarriage rate: 2.23% vs. 3.04% vs. 7.35%, P&lt;0.001; for macrosomia: 0.21% vs. 1.70% vs. 3.23%, P=0.002). Increased HOMA-IR (HOMA-IR≥2.71) was positively associated with late miscarriage (crude OR 3.50, 95% CI 1.64-7.47, P=0.001; adjusted OR 3.56, 95% CI 1.56-8.15, P=0.003). In the subgroup analysis, there were 3,165 participants in the non-PCOS group and 450 were assigned to the PCOS group. Late miscarriage rate increased with the HOMA-IR group among non-PCOS populations (2.20% vs. 3.03% vs. 7.67%, P&lt;0.001). Late miscarriage rate of PCOS women were comparable among the three HOMA-IR groups (2.50% vs. 3.06% vs. 5.71%, P=0.634). Among non-PCOS women, increased HOMA-IR (HOMA-IR≥2.71) was positively associated with late miscarriage (crude OR 3.71, 95% CI 1.66-8.30, P=0.001; adjusted OR 3.82, 95% CI 1.59-9.17, P=0.003).ConclusionsLate miscarriage rate and prevalence of macrosomia increased with the HOMA-IR index. Preconception HOMA-IR is an independent risk factor for late miscarriage in normolipidemic women undergoing IVF/ICSI-ET. Controlling insulin resistance before ART might prevent the occurrence of late miscarriage and macrosomia.