bluuebunny/crossref_metadata_2025_split huggingface dataset:
Art World Fields and Global Hegemonies
Authors: MacKay Joseph 
Published: June 2022

AbstractThis paper investigates the art world as a setting for hegemonic status or prestige politics. Powerful states engage in art world status-seeking but appear to face challenges distinct to the art world in so doing. To explain, I adopt a Bourdieusian forms of capital approach, framing the art world as a social field with distinctive contentious dynamics and symbolic politics. I argue states must work through art world networks and institutions to pursue status there, observing local rules in so doing. I frame art world prestige as symbolic capital—the overt, observable pursuit of which tends to undermine any gains. Hegemonic incumbents and challengers face differing such constraints. The existing global art world models rules and standards by homology on that of the current hegemon. A challenger must adapt to this status quo before they can revise it. I unpack these dynamics in the cases of America, China, and India. I focus on their shifting standing in the global art market and performances of national aggrandizement at a recurring global art world event: the Venice Biennale.
Improvement of Umbilical Cord Blood Gas Analysis with Implementation of Clot Catchers
Authors: Engelstad Michael , Tenney Brandon , Brooks Eugene , Thimm Matthew , Sheffield Jeanne S , Baschat Ahmet , Knezevic Claire E 
Published: June 2022

Abstract

Background
Umbilical cord blood gas testing is a key component of objective pre- and perinatal evaluation of fetal acid base status to determine presence of intrapartum asphyxia and risk of neonatal encephalopathy. Heparinized cord blood is more likely to form small clots than other blood sources, which can interfere with, or preclude, sample analysis. Cord blood samples are irreplaceable and cannot be recollected, thereby compromising clinical decision-making when analysis is not possible. We evaluated processes to prevent excessive rates of cord blood clotting and quantified their impact on successful testing of blood gas specimens.

Methods
Verified result and cancellation data were obtained retrospectively from the laboratory information system. Clot catchers were evaluated using noncord remnant specimens. Collection syringes were compared via collection from remnant cord sections.

Results
Prior to implementation of any interventions, retrospective analysis indicated a cancellation rate of 18.6% for umbilical cord blood gas specimens (arterial and venous) and 0.7% for noncord blood arterial and venous samples. Clot catchers were validated for clinical use, with a bias of &lt;±4% for all analytes. After clot catchers were implemented for all cord specimens, cancellation rate decreased approximately 5-fold in the first month and remained &lt;5% a year after implementation. A limited comparison of two heparin syringe types revealed a small difference in the overall rate of specimen clotting.

Conclusions
Implementation of clot catchers was acceptable for analysis of cord blood samples, and when implemented resulted in a sustained 5-fold decrease in the rate of cord blood gas order cancellation.
Gilt development to improve offspring performance and survivability
Authors: Faccin Jamil E G , Tokach Mike D , Goodband Robert D , DeRouchey Joel M , Woodworth Jason C , Gebhardt Jordan T 
Published: June 2022

AbstractMethods for developing incoming replacement gilts can indirectly and directly influence survivability of their offspring. Indirectly, having proper gilt development reduces culling rates and mortality, which increases longevity and creates a more mature sow herd. Older sows are more likely to have greater immunity than gilts and therefore can pass this along to their pigs in both quantity and quality of colostrum and milk, thus improving piglet survivability. Directly, proper gilt development will maximize mammary gland development which increases colostrum and milk production leading to large, healthy pig. As for the developing gilt at birth, increasing colostrum intake, reducing nursing pressure, providing adequate space allowance, and good growth rate can increase the likelihood that gilts successfully enter and remain in the herd. Light birth weight gilts (&lt;1 kg) or gilts from litters with low birth weight should be removed early in the selection process. Gilts should be weaned at 24 d of age or older and then can be grown in a variety of ways as long as lifetime growth rate is over 600 g/d. Current genetic lines with exceptional growth rate run the risk of being bred too heavy, reducing longevity. On the other hand, restricting feed intake at specific times could be detrimental to mammary development. In these situations, reducing diet amino acid concentration and allowing ad libitum feed is a possible strategy. Gilts should be bred between 135 and 160 kg and at second estrus or later while in a positive metabolic state to increase lifetime productivity and longevity in the herd. Once bred, gilts should be fed to maintain or build body reserves without becoming over-conditioned at farrowing. Proper body condition at farrowing impacts the percentage of pigs born alive as well as colostrum and milk production, and consequently, offspring performance and survivability. Combined with the benefit in pig immunity conferred by an older sow parity structure, gilt development has lasting impacts on offspring performance and survivability.
Novel small synthetic HIV-1 V3 crown variants: CCR5 targeting ligands
Authors: Anitha Anju Krishnan , Narayanan Pratibha , Ajayakumar Neethu , Sivakumar Krishnankutty Chandrika , Kumar Kesavakurup Santhosh 
Published: June 2022

Abstract
The CC chemokine receptor 5 (CCR5) antagonism represents a promising pharmacological strategy for therapeutic intervention as it plays a significant role in reducing the severity and progression of a wide range of pathological conditions. Here we designed and generated peptide ligands targeting the chemokine receptor, CCR5, that were derived from the critical interaction sites of the V3 crown domain of envelope protein glycoprotein gp120 (TRKSIHIGPGRAFYTTGEI) of HIV-1 using computational biology approach and the peptide sequence corresponding to this region was taken as the template peptide, designated as TMP-1. The peptide variants were synthesized by employing Fmoc chemistry using polymer support and were labelled with rhodamine B to study their interaction with the CCR5 receptor expressed on various cells. TMP-1 and TMP-2 were selected as the high-affinity ligands from in vitro receptor-binding assays. Specific receptor-binding experiments in activated peripheral blood mononuclear cells and HOS.CCR5 cells indicated that TMP-1 and TMP-2 had significant CCR5 specificity. Further, the functional analysis of TMP peptides using chemotactic migration assay showed that both peptides did not mediate the migration of responsive cells. Thus, template TMP-1 and TMP-2 represent promising CCR5 targeting peptide candidates.
Transcriptomic analysis elucidates evolution of the major histocompatibility complex class I in neotropical bats
Authors: Moreno-Santillán Diana D , Machain-Williams Carlos , Hernández-Montes Georgina , Ortega Jorge 
Published: June 2022

Abstract
The Order Chiroptera comprises more than 1,400 species, each with its evolutionary history and under unique selective pressures, among which are the host–pathogen interactions. Bats have coped with complex interactions with a broad spectrum of microbes throughout their evolutionary history, prompting the development of unique adaptations that allow them to co-exist with microbes with pathogenic potential more efficiently than other nonadapted species. In this sense, an extraordinary immune system with unique adaptations has been hypothesized in bats. To explore this, we focused on the major histocompatibility complex (MHC), which plays a crucial role in pathogen recognition and presentation to T cells to trigger the adaptive immune response. We analyzed MHC class I transcripts in five species, each from different families of New World bats. From RNA-seq data, we assembled a partial region of the MHC-I comprising the α1 and α2 domains, which are responsible for peptide binding and recognition. We described five putative functional variants, two of which have two independent insertions at the α2 domain. Our results suggest that this insertion appeared after the divergence of the order Chiroptera and may have an adaptive function in the defense against intracellular pathogens, providing evidence of positive selection and trans-specific polymorphism on the peptide-binding sites.
Chest wall perforator flap to partially reconstruct central mound of breast tissue – evolution of the technique
Authors: Sundara Rajan Sreekumar , Verma Rashmi , Murthy Bade L 
Published: June 2022

Abstract
We describe the use of chest wall perforator flap (CWPF) to reconstruct the central mound of breast tissue in women presenting with central/retro areolar breast cancer. We describe the results of seven patients (median age, 59 years) with a median follow-up of 9 months. We were able to conserve the breast in all except one woman who was found to have extensive DCIS. Two patients were taken back to theatre, one for a washout of infected seroma and second for a wound debridement. There was no flap loss or donor site complications in our series. We were able to conserve the breast, maintain aesthetic contour of the central mound along with projection and achieve excellent cosmetic outcome for our patients. Partial breast reconstruction using CWPF provides an oncologically safe and cosmetically superior alternative in selected women with breast cancer needing central wide local excision.
Cardew’s Lessons: The Scratch Orchestra’s Amateur Democracy (1967–1973)
Authors: Court Benjamin 
Published: June 2022

ABSTRACT
Between 1967 and 1973 Cornelius Cardew taught at three different London institutions—a traditional music conservatory (the Royal Academy of Music), an adult education college (Morley College), and a politically radical free school (the Antiuniversity of London). These schools introduced Cardew to a wide range of technical musical abilities and profoundly affected the composer’s works and pedagogy, culminating in a new musical organization: the Scratch Orchestra. This essay details the political implications of Cardew’s teaching philosophy within the Scratch Orchestra and the lessons to be gleaned from the Orchestra’s successes and failures, particularly the fundamental necessity of disagreement in egalitarian musical classrooms and improvisatory collaborations. To amplify these lessons, I analyse how the musical structures of ‘Paragraph 2’ of Cardew’s The Great Learning belie the composer’s own politics by prescribing distinctly hierarchical performance roles.
The plastid-encoded protein Orf2971 is required for protein translocation and chloroplast quality control
Authors: Xing Jiale , Pan Junting , Yi Heng , Lv Kang , Gan Qiuliang , Wang Meimei , Ge Haitao , Huang Xiahe , Huang Fang , Wang Yingchun , Rochaix Jean-David , Yang Wenqiang 
Published: June 2022

Abstract
Photosynthesis and the biosynthesis of many important metabolites occur in chloroplasts. In these semi-autonomous organelles, the chloroplast genome encodes approximately 100 proteins. The remaining chloroplast proteins, close to 3,000, are encoded by nuclear genes whose products are translated in the cytosol and imported into chloroplasts. However, there is still no consensus on the composition of the protein import machinery including its motor proteins and on how newly imported chloroplast proteins are refolded. In this study, we have examined the function of orf2971, the largest chloroplast gene of Chlamydomonas reinhardtii. The depletion of Orf2971 causes the accumulation of protein precursors, partial proteolysis and aggregation of proteins, increased expression of chaperones and proteases, and autophagy. Orf2971 interacts with the TIC (translocon at the inner chloroplast envelope) complex, catalyzes ATP (adenosine triphosphate) hydrolysis, and associates with chaperones and chaperonins. We propose that Orf2971 is intimately connected to the protein import machinery and plays an important role in chloroplast protein quality control.
WRKY63 transcriptional activation of COOLAIR and COLDAIR regulates vernalization-induced flowering
Authors: Hung Fu-Yu , Shih Yuan-Hsin , Lin Pei-Yu , Feng Yun-Ru , Li Chenlong , Wu Keqiang 
Published: June 2022

Abstract
Arabidopsis (Arabidopsis thaliana) FLOWERING LOCUS C (FLC) acts as a key flowering regulator by repressing the expression of the floral integrator FLOWERING LOCUS T (FT). Prolonged exposure to cold (vernalization) induces flowering by reducing FLC expression. The long noncoding RNAs (lncRNAs) COOLAIR and COLDAIR, which are transcribed from the 3′ end and the first intron of FLC, respectively, are important for FLC repression under vernalization. However, the molecular mechanism of how COOLAIR and COLDAIR are transcriptionally activated remains elusive. In this study, we found that the group-III WRKY transcription factor WRKY63 can directly activate FLC. wrky63 mutant plants display an early flowering phenotype and are insensitive to vernalization. Interestingly, we found that WRKY63 can activate the expression of COOLAIR and COLDAIR by binding to their promoters.WRKY63 therefore acts as a dual regulator that activates FLC directly under non-vernalization conditions but represses FLC indirectly during vernalization through inducing COOLAIR and COLDAIR. Furthermore, genome-wide occupancy profile analyses indicated that the binding of WRKY63 to vernalization-induced genes increases after vernalization. In addition, WRKY63 binding is associated with decreased levels of the repressive marker Histone H3 Lysine 27 trimethylation (H3K27me3). Collectively, our results indicate that WRKY63 is an important flowering regulator involved in vernalization-induced transcriptional regulation.
University policy engagement bodies in the UK and the variable meanings of and approaches to impact
Authors: Durrant Hannah , MacKillop Eleanor 
Published: June 2022

Abstract
Over the last decade, there has been a proliferation of policy engagement bodies set up within universities worldwide. The present study focuses on the British experience of this phenomenon but with relevance to other contexts. Multiple factors are at play to explain this growth, from the Research Excellence Framework impact agenda (which assesses and ranks the quality of research in UK universities and has been echoed in other countries) to universities’ renewed focus on their civic mission, and a growing demand within policy and practice circles for more research evidence. Based on interviews with senior staff and analysis of their websites and documentary outputs, this article offers a comprehensive catalogue of university policy engagement bodies across the UK, and classifies them into types based on their activities, outputs, impact, and staff. We enrich this categorization by examining the stories these bodies tell to explain how and why they have emerged, and the variable approaches they adopt as they seek to influence both academic and policymaking practices. In doing so, we develop a typology of university policy engagement bodies, and demonstrate how they seek to partake in changing the roles and identities of universities, and their relationship with policymaking.
Lung vascular changes as biomarkers of severity in systemic sclerosis–associated interstitial lung disease
Authors: Bruni Cosimo , Occhipinti Mariaelena , Pienn Michael , Camiciottoli Gianna , Bartolucci Maurizio , Bosello Silvia Laura , Payer Christian , Bálint Zoltán , Larici Anna Rita , Tottoli Alessandra , Tofani Lorenzo , De Lorenzis Enrico , Lepri Gemma , Bellando-Randone Silvia , Spinella Amelia , Giuggioli Dilia , Masini Francesco , Cuomo Giovanna , Lavorini Federico , Colagrande Stefano , Olschewski Horst , Matucci-Cerinic Marco 
Published: June 2022

Abstract

Objectives
It has recently become possible to assess lung vascular and parenchymal changes quantitatively in thoracic CT images using automated software tools. We investigated the vessel parameters of patients with SSc, quantified by CT imaging, and correlated them with interstitial lung disease (ILD) features.

Methods
SSc patients undergoing standard of care pulmonary function testing and CT evaluation were retrospectively evaluated. CT images were analysed for ILD patterns and total pulmonary vascular volume (PVV) extents with Imbio lung texture analysis. Vascular analysis (volumes, numbers and densities of vessels, separating arteries and veins) was performed with an in-house developed software. A threshold of 5% ILD extent was chosen to define the presence of ILD, and commonly used cut-offs of lung function were adopted.

Results
A total of 79 patients [52 women, 40 ILD, mean age 56.2 (s.d. 14.2) years, total ILD extent 9.5 (10.7)%, PVV/lung volume % 2.8%] were enrolled. Vascular parameters for total and separated PVV significantly correlated with functional parameters and ILD pattern extents. SSc-associated ILD (SSc-ILD) patients presented with an increased number and volume of arterial vessels, in particular those between 2 and 4 mm of diameter, and with a higher density of arteries and veins of &lt;6 mm in diameter. Considering radiological and functional criteria concomitantly, as well as the descriptive trends from the longitudinal evaluations, the normalized PVVs, vessel numbers and densities increased progressively with the increase/worsening of ILD extent and functional impairment.

Conclusion
In SSc patients CT vessel parameters increase in parallel with ILD extent and functional impairment, and may represent a biomarker of SSc-ILD severity.
Treatment Decision-Making Capacity in Forensic vs Non-forensic Psychiatric Patients: A European Comparison
Authors: Marazia Chantal , Rucci Paola , Fangerau Heiner , Voßberg Dilara , Rolfes Vasilija , Iozzino Laura , Iommi Marica , Gosek Pawel , Heitzman Janusz , Ferrari Clarissa , Macis Ambra , Markiewicz Inga , Picchioni Marco , Salize Hans Joachim , Stompe Thomas , Wancata Johannes , Appelbaum Paul S , de Girolamo Giovanni 
Published: June 2022

AbstractBackgroundConsent to treatment is a cornerstone of medical ethics and law. Nevertheless, very little empirical evidence is available to inform clinicians and policymakers regarding the capacities of forensic patients with schizophrenia spectrum disorders (SSDs) to make decisions about their treatment, with the risk of clinical and legal inertia, silent coercion, stigmatization, or ill-conceived reforms.Study DesignIn this multinational study, we assessed and compared with treatment-related decisional capacities in forensic and non-forensic patients with SSD. 160 forensic and 139 non-forensic patients were used in Austria, Germany, Italy, Poland, and England. Their capacity to consent to treatment was assessed by means of the MacArthur Competence Assessment Tool for Treatment (MacCAT-T). Multiple generalized linear regression models were used to identify the socio-demographic and clinical variables associated with MacCAT-T scores.Study ResultsIn total, 55 forensic (34.4%) and 58 non-forensic patients (41.7%) showed high treatment-related decisional capacity, defined as scoring ≥75% of the maximum scores for the understanding, appreciation and reasoning, and 2 for expressing a choice. Forensic patients showed differences in their capacity to consent to treatment across countries. Of all socio-demographic and clinical variables, only “social support” was directly relevant to policy.ConclusionsForensic patients have treatment-related decisional capacities comparable with their non-forensic counterparts. Social contacts might provide a substantial contribution towards enhancing the decisional autonomy of both forensic and non-forensic patients, hence improving the overall quality and legitimacy of mental health care.
Detecting and Removing Sample Contamination in Phylogenomic Data: An Example and its Implications for Cicadidae Phylogeny (Insecta: Hemiptera)
Authors: Owen Christopher L , Marshall David C , Wade Elizabeth J , Meister Russ , Goemans Geert , Kunte Krushnamegh , Moulds Max , Hill Kathy , Villet M , Pham Thai-Hong , Kortyna Michelle , Lemmon Emily Moriarty , Lemmon Alan R , Simon Chris 
Published: June 2022

Abstract
Contamination of a genetic sample with DNA from one or more nontarget species is a continuing concern of molecular phylogenetic studies, both Sanger sequencing studies and next-generation sequencing studies. We developed an automated pipeline for identifying and excluding likely cross-contaminated loci based on the detection of bimodal distributions of patristic distances across gene trees. When contamination occurs between samples within a data set, a comparison between a contaminated sample and its contaminant taxon will yield bimodal distributions with one peak close to zero patristic distance. This new method does not rely on a priori knowledge of taxon relatedness nor does it determine the causes(s) of the contamination. Exclusion of putatively contaminated loci from a data set generated for the insect family Cicadidae showed that these sequences were affecting some topological patterns and branch supports, although the effects were sometimes subtle, with some contamination-influenced relationships exhibiting strong bootstrap support. Long tip branches and outlier values for one anchored phylogenomic pipeline statistic (AvgNHomologs) were correlated with the presence of contamination. While the anchored hybrid enrichment markers used here, which target hemipteroid taxa, proved effective in resolving deep and shallow level Cicadidae relationships in aggregate, individual markers contained inadequate phylogenetic signal, in part probably due to short length. The cleaned data set, consisting of 429 loci, from 90 genera representing 44 of 56 current Cicadidae tribes, supported three of the four sampled Cicadidae subfamilies in concatenated-matrix maximum likelihood (ML) and multispecies coalescent-based species tree analyses, with the fourth subfamily weakly supported in the ML trees. No well-supported patterns from previous family-level Sanger sequencing studies of Cicadidae phylogeny were contradicted. One taxon (Aragualna plenalinea) did not fall with its current subfamily in the genetic tree, and this genus and its tribe Aragualnini is reclassified to Tibicininae following morphological re-examination. Only subtle differences were observed in trees after the removal of loci for which divergent base frequencies were detected. Greater success may be achieved by increased taxon sampling and developing a probe set targeting a more recent common ancestor and longer loci. Searches for contamination are an essential step in phylogenomic analyses of all kinds and our pipeline is an effective solution. [Auchenorrhyncha; base-composition bias; Cicadidae; Cicadoidea; Hemiptera; phylogenetic conflict.]