bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIADH & Diabetes insipidus: Neues zu Diagnosestellung und Therapie
Authors: Fenske Wiebke , Charlotte Fries 
Published: August 2022

Was ist neu?
COVID-19 und Störungen der Wasser- und Natriumhomöostase Eine Dysnatriämie tritt bei hospitalisierten Patient*innen mit COVID-19 gehäuft auf und ist mit einer erhöhten Mortalität und vermehrt septischen Verläufen assoziiert. Insbesondere eine profunde Hyponatriämie kann auch Ausdruck für ein zugrunde liegendes Syndrom der inadäquaten AVP-Sekretion (SIADH) oder einen Cortisolmangel unter COVID-19-Infektion sein. Patient*innen mit bereits bekannten Störungen des AVP-Systems – wie dem SIADH oder Diabetes insipidus – sind einem erhöhten Risiko einer mitunter schwerwiegenden Elektrolyt-Entgleisung unter COVID-19-Infektion ausgesetzt und sollten engmaschig kontrolliert werden.
Hyponatriämie unter Immun-Checkpoint-Blockade – nicht immer SIADH Der wachsende Einsatz von Immun-Checkpoint-Inhibitoren (ICI) in der Tumortherapie hat auch zu einem Zuwachs von immunvermittelten endokrinen Nebenwirkungen geführt. Diese können zeitlich sehr variabel, auch noch nach Beendigung einer ICI-Therapie, auftreten und initial eine unspezifische Klinik aufweisen. Als ein einfacher, allgemein verfügbarer Biomarker und zugleich sensitives Warnsignal für mögliche endokrine Nebenwirkungen kann die Hyponatriämie dienen. Eine unklare und neu aufgetretene Hyponatriämie unter ICI-Therapie sollte vor Diagnose eines SIADH stets abgeklärt und endokrine Nebenwirkungen sollten ausgeschlossen werden.
Neue Evidenz in der Behandlung der akuten und chronischen Hyponatriämie In der Behandlung der akuten symptomatischen Hyponatriämie eignen sich sowohl die rasche intermittierende Bolusgabe als auch die langsam kontinuierliche Infusion von 3 % NaCl zur Akuttherapie. Die Bolusgabe bietet eine geringe Überlegenheit im Sicherheitsprofil und wird in den Empfehlungen der Europäischen Praxisleitlinie favorisiert. In der Behandlung der chronischen Hyponatriämie bei SIADH ist die Flüssigkeitsrestriktion als Erstlinientherapie ein probates Mittel zur Elektrolyt-Korrektur. Die additive Gabe von Furosemid und NaCl-Kapseln zeigt keine gesteigerte Wirkeffizienz, jedoch eine schlechtere Verträglichkeit.
Copeptin-basierte Diagnostik in der Abklärung des Polyurie-Polydipsie-Syndroms Bei der Abklärung des Polyurie-Polydipsie-Syndroms ist die Sicherung einer hypotonen Polyurie vor der erweiterten diagnostischen Differenzierung essenziell. Copeptin-basierte Testverfahren zeigen eine deutliche Überlegenheit gegenüber dem indirekten Durstversuch in der Differenzierung zwischen Patient*innen mit einem Diabetes insipidus und einer Primären Polydipsie. Das eskalierende Vorgehen der diagnostischen Verfahren ist ebenso zielführend wie ressourceneffizient.
Rezidivierende Harnwegsinfektionen – was tun?
Authors: Klußmann Daniel , Wagenlehner Florian 
Published: August 2022

Was ist neu?
Nicht antibiotische Therapieregime Neben allgemeiner Aufklärung und Beratung über Risikofaktoren von Harnwegsinfektionen sind vor allem die nichtantibiotischen Therapie-Optionen zur Rezidivreduktion wichtig. Das Ziel hierbei ist es, Resistenzentwicklungen und den entsprechenden unerwünschten Nebenwirkungen von Antibiotika vorzubeugen. Zu den nicht antibiotischen Strategien zählen allen voran eine persönliche Beratung mit Vermittlung von Verhaltensempfehlungen, die Immunoprophylaxe, Phytotherapeutika, sowie eine lokale Östrogensubstitution
Antibiotische Prävention Bei hohem Leidensdruck der Patientinnen ist jedoch nach entsprechender Abwägung auch eine antibiotische Prophylaxe in Betracht zu ziehen. Zusammenfassend sollte eine individuelle Beratung erfolgen und es sollte mit einem multimodalen Therapieansatz behandelt werden.
Fehlendes Therapieansprechen: Ist es wirklich eine rheumatoide Arthritis?
Authors: Marinoska Tatjana , Lauf Carla , Schorn Corinna , Schwarting Andreas 
Published: August 2022

Zusammenfassung
Anamnese Eine 78-jährige Patientin wurde unserer Klinik mit einer therapieresistenten, seronegativen und ACPA-negativen rheumatoiden Arthritis zugewiesen. Der Verlauf war von hoher klinischer Krankheitsaktivität und rascher Progression der erosiven Veränderungen geprägt. Unter der erforderlichen hochdosierten Prednisolon-Therapie kam es zu einer Osteoporose sowie einer TVT mit Lungenembolie.
Körperliche Untersuchung Bei Aufnahme bestanden symmetrische, schmerzhafte, synovialitische Schwellungen der MCPs, PIPs und DIPs, Fingergelenk-bezogene rötlich-livide Verfärbungen sowie Kontrakturen der Langfinger und fortgeschrittene Deformitäten. Eine ausgeprägte proximale Muskelschwäche führte zu Einschränkungen beim Treppensteigen sowie beim An- und Auskleiden.
Diagnostik Das Labor zeigte bei negativem RF und anti-CCP-Ak einen positiven ANA (1:5120) mit nukleärem Fluoreszenzmuster und einen positiven anti-Mi-2-Ak im Myositis-Blot. Nativradiologisch imponierten fortgeschrittene mutilierende Gelenkveränderungen im Bereich beider Hände, in der Magnet-Resonanz-Tomografie (MRT) der Oberarme zeigte sich eine ausgeprägte Atrophie der Oberarmmuskulatur ohne Hinweis auf eine aktive Myositis. Diese klinische Konstellation führte zu der Diagnosestellung einer amyositischen Dermatomyositis.
Therapie und Verlauf Unter einem initial erhaltenen Steroidstoß von 100 mg Prednisolon i. v./Tag über 4 Tage waren die klinischen Beschwerden rückläufig. Bei begleitenden Risikofaktoren (Osteoporosis, arterieller Hypertonie, verschwommenem Sehen) erfolgte ein schnelles Steroid-Tapering. Die Basistherapie wurde auf Rituximab umgestellt. Eine erweiterte Tumorsuche wurde ambulant empfohlen.
Diskussion Eine seronegative, ACPA-negative, therapieresistente RA mit schnell fortschreitendem erosivem Verlauf erfordert eine diagnostische Re-Evaluation. Eine erosive, rapid progressive Polyarthritis gehört zu dem Krankheitsbild der mit Anti-Jo-1-Antikörpern assoziierten idiopathischen Myopathien, dem Antisynthetase-Syndrom. Allerdings sind auch Assoziationen mit dem Vorhandensein anderer Myositis-spezifischer Antikörper (MSA) beschrieben. Die Anti-Mi-2-Ab sind hochspezifisch für Dermatomyositis (DM). Eine amyopathische DM ist selten und untypisch. Trotzdem, abgesehen von der muskulären Beteiligung, unterscheiden sich der Krankheitsverlauf und die Prognose nicht wesentlich von einer myopathischen DM.Da eine plötzlich aufgetretene DM eine paraneoplastische Genese haben könnte, ist eine erweiterte Diagnostik zum Malignom-Ausschluss indiziert.
The Impact of “Fear of Falling” on Physical Performance, Balance, and Ambulation in Duchenne Muscular Dystrophy
Authors: Alemdaroğlu-Gürbüz İpek , İpek Canan , Bulut Numan , Karaduman Ayşe , Yılmaz Öznur 
Published: August 2022

Abstract
Objective The aim of this study was to investigate falls and the fear of falling (FOF) in children with Duchenne muscular dystrophy (DMD) and to determine the relationships between the FOF and physical performance, balance, and ambulation.
Methods Thirty-eight ambulatory children with DMD were included in the study. The functional level, falling history, FOF, physical performance, balance, and ambulation were assessed by using Brooke Lower Extremity Functional Classification, History of Falls Questionnaire, Pediatric Fear of Falling Questionnaire (Ped-FOF), timed performance tests, Timed “Up and Go” (TUG) test, and North Star Ambulatory Assessment (NSAA), respectively.
Results Of the 38 children (mean age: 9.00 ± 2.03 years) 97.4% had a history of serious fall last year and 62.2% were injured due to this fall. The Ped-FOF score was 13.79 ± 7.20. Weak to moderate relations were determined between Ped-FOF and functional level (r = 0.33), frequency of falls (r = 0.41), duration of climbing 4-steps (r = 0.38), TUG (r = 0.36), and NSAA (r = –0.32) (p < 0.05).
Conclusion Ambulatory children with better performance scores had lower levels of FOF despite their history of serious falls and injuries. FOF tends to increase as the symptoms of the disease progresses. Investigating the history of falls and FOF from the earliest period will guide to take precautions and make necessary interventions on time in treatment programs.
The EEG multiverse of schizophrenia
Authors: Gordillo Dario , da Cruz Janir Ramos , Chkonia Eka , Lin Wei-Hsiang , Favrod Ophélie , Brand Andreas , Figueiredo Patrícia , Roinishvili Maya , Herzog Michael H 
Published: August 2022

AbstractResearch on schizophrenia typically focuses on one paradigm for which clear-cut differences between patients and controls are established. Great efforts are made to understand the underlying genetical, neurophysiological, and cognitive mechanisms, which eventually may explain the clinical outcome. One tacit assumption of these “deep rooting” approaches is that paradigms tap into common and representative aspects of the disorder. Here, we analyzed the resting-state electroencephalogram (EEG) of 121 schizophrenia patients and 75 controls. Using multiple signal processing methods, we extracted 194 EEG features. Sixty-nine out of the 194 EEG features showed a significant difference between patients and controls, indicating that these features detect an important aspect of schizophrenia. Surprisingly, the correlations between these features were very low. We discuss several explanations to our results and propose that complementing “deep” with “shallow” rooting approaches might help in understanding the underlying mechanisms of the disorder.
Functional brain activity is highly associated with cortical myelination in neonates
Authors: Huang Ziyi , Gao Wenjian , Wu Zhengwang , Li Gang , Nie Jingxin 
Published: August 2022

AbstractFunctional organization of the human cerebral cortex is highly constrained by underlying brain structures, but how functional activity is associated with different brain structures during development is not clear, especially at the neonatal stage. Since long-range functional connectivity is far from mature in the dynamically developing neonatal brain, it is of great scientific significance to investigate the relationship between different structural and functional features at the local level. To this end, for the first time, correlation and regression analyses were performed to examine the relationship between cortical morphology, cortical myelination, age, and local brain functional activity, as well as functional connectivity strength using high-resolution structural and resting-state functional MRI data of 177 neonates (29–44 postmenopausal weeks, 98 male and 79 female) from both static and dynamic perspectives. We found that cortical myelination was most strongly associated with local brain functional activity across the cerebral cortex than other cortical structural features while controlling the age effect. These findings suggest the crucial role of cortical myelination in local brain functional development at birth, providing valuable insights into the fundamental biological basis of functional activity at this early developmental stage.
Abnormal dynamic reconfiguration of the large-scale functional network in schizophrenia during the episodic memory task
Authors: Wang Bin , Pan Tingting , Guo Min , Li Zhifeng , Yu Xuexue , Li Dandan , Niu Yan , Cui Xiaohong , Xiang Jie 
Published: August 2022

AbstractEpisodic memory deficits are the core feature in schizophrenia (SCZ). Numerous studies have revealed abnormal brain activity associated with this disorder during episodic memory, however previous work has only relied on static analysis methods that treat the brain as a static monolithic structure, ignoring the dynamic features at different time scales. Here, we applied dynamic functional connectivity analysis to functional magnetic resonance imaging data during episodic memory and quantify integration and recruitment metrics to reveal abnormal dynamic reconfiguration of brain networks in SCZ. In the specific frequency band of 0.06–0.125 Hz, SCZ showed significantly higher integration during encoding and retrieval, and the abnormalities were mainly in the default mode, frontoparietal, and cingulo-opercular modules. Recruitment of SCZ was significantly higher during retrieval, mainly in the visual module. Interestingly, interactions between groups and task status in recruitment were found in the dorsal attention, visual modules. Finally, we observed that integration was significantly associated with memory performance in frontoparietal regions. Our findings revealed the time-varying evolution of brain networks in SCZ, while improving our understanding of cognitive decline and other pathophysiologies in brain diseases.
Sncg,Mybpc1, andParm1Classify subpopulations of VIP-expressing interneurons in layers 2/3 of the somatosensory cortex
Authors: Jiang Shao-Na , Cao Jun-Wei , Liu Lin-Yun , Zhou Ying , Shan Guang-Yao , Fu Ying-Hui , Shao Yun-Chao , Yu Yong-Chun 
Published: August 2022

AbstractNeocortical vasoactive intestinal polypeptide-expressing (VIP+) interneurons display highly diverse morpho-electrophysiological and molecular properties. To begin to understand the function of VIP+ interneurons in cortical circuits, they must be clearly and comprehensively classified into distinct subpopulations based on specific molecular markers. Here, we utilized patch-clamp RT-PCR (Patch-PCR) to simultaneously obtain the morpho-electric properties and mRNA profiles of 155 VIP+ interneurons in layers 2 and 3 (L2/3) of the mouse somatosensory cortex. Using an unsupervised clustering method, we identified 3 electrophysiological types (E-types) and 2 morphological types (M-types) of VIP+ interneurons. Joint clustering based on the combined electrophysiological and morphological features resulted in 3 morpho-electric types (ME-types). More importantly, we found these 3 ME-types expressed distinct marker genes: ~94% of Sncg+ cells were ME-type 1, 100% of Mybpc1+ cells were ME-type 2, and ~78% of Parm1+ were ME-type 3. By clarifying the properties of subpopulations of cortical L2/3 VIP+ interneurons, this study establishes a basis for future investigations aiming to elucidate their physiological roles.
Last year of life of adults with congenital heart diseases: causes of death and patterns of care
Authors: Van Bulck Liesbet , Goossens Eva , Morin Lucas , Luyckx Koen , Ombelet Fouke , Willems Ruben , Budts Werner , De Groote Katya , De Backer Julie , Annemans Lieven , Moniotte Stéphane , de Hosson Michèle , Marelli Arianne , Moons Philip ,   BELCODAC consortium
Published: August 2022

Abstract

Aims
Although life expectancy in adults with congenital heart diseases (CHD) has increased dramatically over the past five decades, still a substantial number of patients dies prematurely. To gain understanding in the trajectories of dying in adults with CHD, the last year of life warrants further investigation. Therefore, our study aimed to (i) define the causes of death and (ii) describe the patterns of healthcare utilization in the last year of life of adults with CHD.

Methods and results
This retrospective mortality follow-back study used healthcare claims and clinical data from BELCODAC, which includes patients with CHD from Belgium. Healthcare utilization comprises cardiovascular procedures, CHD physician contacts, general practitioner visits, hospitalizations, emergency department (ED) visits, intensive care unit (ICU) admissions, and specialist palliative care, and was identified using nomenclature codes. Of the 390 included patients, almost half of the study population (45%) died from a cardiovascular cause. In the last year of life, 87% of patients were hospitalized, 78% of patients had an ED visit, and 19% of patients had an ICU admission. Specialist palliative care was provided to 17% of patients, and to only 4% when looking at the patients with cardiovascular causes of death.

Conclusions
There is a high use of intensive and potentially avoidable care at the end of life. This may imply that end-of-life care provision can be improved. Future studies should further examine end-of-life care provision in the light of patient’s needs and preferences, and how the healthcare system can adequately respond.
Device-related complications in subcutaneous versus transvenous ICD: a secondary analysis of the PRAETORIAN trial
Authors: Knops Reinoud E , Pepplinkhuizen Shari , Delnoy Peter Paul H M , Boersma Lucas V A , Kuschyk Juergen , El-Chami Mikhael F , Bonnemeier Hendrik , Behr Elijah R , Brouwer Tom F , Kaab Stefan , Mittal Suneet , Quast Anne-Floor B E , van der Stuijt Willeke , Smeding Lonneke , de Veld Jolien A , Tijssen Jan G P , Bijsterveld Nick R , Richter Sergio , Brouwer Marc A , de Groot Joris R , Kooiman Kirsten M , Lambiase Pier D , Neuzil Petr , Vernooy Kevin , Alings Marco , Betts Timothy R , Bracke Frank A L E , Burke Martin C , de Jong Jonas S S G , Wright David J , Jansen Ward P J , Whinnett Zachary I , Nordbeck Peter , Knaut Michael , Philbert Berit T , van Opstal Jurren M , Chicos Alexandru B , Allaart Cornelis P , Borger van der Burg Alida E , Dizon Jose M , Miller Marc A , Nemirovsky Dmitry , Surber Ralf , Upadhyay Gaurav A , Weiss Raul , de Weger Anouk , Wilde Arthur A M , Olde Nordkamp Louise R A 
Published: August 2022

Abstract

Background
The subcutaneous implantable cardioverter-defibrillator (S-ICD) is developed to overcome lead-related complications and systemic infections, inherent to transvenous ICD (TV-ICD) therapy. The PRAETORIAN trial demonstrated that the S-ICD is non-inferior to the TV-ICD with regard to the combined primary endpoint of inappropriate shocks and complications. This prespecified secondary analysis evaluates all complications in the PRAETORIAN trial.

Methods and results
The PRAETORIAN trial is an international, multicentre, randomized trial in which 849 patients with an indication for ICD therapy were randomized to receive an S- ICD (N = 426) or TV-ICD (N = 423) and followed for a median of 49 months. Endpoints were device-related complications, lead-related complications, systemic infections, and the need for invasive interventions. Thirty-six device-related complications occurred in 31 patients in the S-ICD group of which bleedings were the most frequent. In the TV-ICD group, 49 complications occurred in 44 patients of which lead dysfunction was most frequent (HR: 0.69; P = 0.11). In both groups, half of all complications were within 30 days after implantation. Lead-related complications and systemic infections occurred significantly less in the S-ICD group compared with the TV-ICD group (P &lt; 0.001, P = 0.03, respectively). Significantly more complications required invasive interventions in the TV-ICD group compared with the S-ICD group (8.3% vs. 4.3%, HR: 0.59; P = 0.047).

Conclusion
This secondary analysis shows that lead-related complications and systemic infections are more prevalent in the TV-ICD group compared with the S-ICD group. In addition, complications in the TV-ICD group were more severe as they required significantly more invasive interventions. This data contributes to shared decision-making in clinical practice.
Management of mushroom resources in Spanish forests: a review
Authors: Domínguez-Núñez José Alfonso , Oliet Juan A 
Published: August 2022

AbstractMycological resources have attracted considerable interest from the public recently. In this context, forest mycological management of wild mushrooms has emerged a research field and is developing rapidly with the objective to sustainably use and conserve mushrooms in multifunctional forests. Although the term ‘mycosilviculture’ was coined relatively recently, forest management of mycological resources and fungal silviculture began already in the 1980s. This study reviews the literature on the forest management of wild mycological resources with emphasis on studies in Spanish Mediterranean forests. The review covers some of the most important aspects of management, such as the diagnosis of mycological resources through inventory and sampling protocols, predictive models of mushroom yield, stand variables and mycosilvicultural practices that affect mushroom yield and fungal diversity. Finally, the potential of mycorrhizal applications for mycosilviculture is briefly discussed. Most of these studies have been based on carpophore inventories, and few have analyzed soil and air fungal biomass. The Mediterranean climate determines mushroom yields; so far, mushroom yields models have been developed mainly for Boletus gr. edulis and Lactarius gr. deliciosus species and for pine forest ecosystems. In the future, it will be necessary to adjust these models to new climatic conditions, and to investigate the complex interactions between different yield and/or fungal diversity factors, adjust the scale of study and fungus-host specificity. So far, few studies have been carried out on mycosilviculture in Mediterranean forests, addressing the effect of thinning and clearcutting on fungal communities; moreover, experiences of mycological management of shrublands, prescribed burning, management of woody debris or selective planting of mycorrhizal seedlings in forests are scarce. The need to study other Mediterranean forest ecosystems is pointed out.
A proof of principle study investigating the effects of supplemental concentrated brewer’s yeast on markers of gut permeability, inflammation, and fecal metabolites in healthy non-challenged adult sled dogs
Authors: Rummell Lindsey M , Steele Michael A , Templeman James R , Yohe Taylor T , Akhtar Nadeem , Lambie Jocelyn G , Singh Pawanpreet , Asquith Thomas , Verbrugghe Adronie , Pearson Wendy , Shoveller Anna K 
Published: August 2022

Abstract
Yeast-derived β-glucans impact immunity, though their effects on gut permeability and inflammation are less understood. Most research has investigated other components of the yeast cell wall, such as the prebiotic mannan- and fructo-oligosaccharides. The objective of this study was to assess the effects of feeding a concentrated yeast product on markers of inflammation (serum amyloid A [SAA] and haptoglobin [Hp]) and oxidative status (malondialdehyde [MDA]), fecal products of fermentation, and gut permeability. Nineteen privately owned domestic Siberian huskies, and one Alaskan husky (9 females: 5 intact, 4 spayed; 11 males: 3 intact, 8 neutered), with an average age of 4.8 ± 2.6 yr and body weight (BW) of 25.6 ± 4.1 kg, were used in this study. Dogs were blocked and randomly allocated to one of two diet groups. Ten dogs received a dry extruded diet. The other 10 received the same diet top dressed with yeast for a daily β–glucan dose of 7 mg/kg BW for 10 wk. Fecal collection, for evaluation of fecal metabolites, and scoring occurred weekly. Gut permeability was assessed using the chromium-labeled ethylenediamine tetra-acetic acid (Cr-EDTA) and iohexol markers prior to the initiation of dietary treatment and after 10 wk of treatment. Blood samples were collected premarker administration and 0.5, 1, 2, 3, 4, 5, and 6 h postadministration. Fasting concentrations of SAA, Hp, and MDA were measured on weeks −1, 2, 4, and 8. Incremental area under the curve (I-AUC) was calculated for serum iohexol and Cr-EDTA concentrations. All data were analyzed using PROC GLIMMIX of SAS with dog as random effect, and week as fixed effect and repeated measure. Dogs receiving treatment tended to have decreased I-AUC of Iohexol (P = 0.10) and Cr-EDTA (P = 0.06) between baseline and cessation of treatment compared to the change over time in I-AUC for control (Ctl) dogs. Treatment dogs had lower Hp concentrations (P ≤ 0.05) than Ctl. There were no differences between treatments for SAA and MDA concentrations (P &gt; 0.05). Fecal arabinose concentrations were greater in treatment (Trt) dogs (P ≤ 0.05) compared to Ctl, though no other fecal metabolites were affected by treatment. There was no difference in the relative frequency of defecations scored at any fecal score between Trt and Ctl dogs, and mean score did not differ between groups (P &gt; 0.10). These data suggest that concentrated brewer’s yeast may have the potential to reduce gut permeability without impacting inflammatory status and markers of health in adult dogs.