bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional Knowledge and Practices in Natural Resource Conservation: A Study of the Zukpiri Community Resource Management Area, Ghana
Authors: Baaweh Louis , Baddianaah Issah , Baatuuwie Bernard Nuoleyeng 
Published: March 2022

Local communities have different perspectives, uses and values ascribed to the diversity of plant and animal species at their service. Yet, local knowledge of the species diversity and use values, alongside conservation decisions and practices, received inadequate scholarly discussion. This article explores how local knowledge of species diversity (flora and fauna) and use values inform decisions for conserving natural resources in the Zukpiri Community Resource Management Area (CREMA). Using the qualitative research approach, seven focus group discussions were held with the Zukpiri CREMA Committees and supported with key informant interviews. The results showed that the CREMA hosts a great diversity of plant and animal species. Customary rules and regulations embedded in customs, traditional beliefs and practices are used in governing, protecting and conserving CREMA’s resources. Drawing on the organisational structure of the CREMA framework in Ghana, we suggest that the Forestry Commission of Ghana should intensify its collaborative role with the Community Resource Management Committees (CRMCs) to monitor illegal logging in and around the CREMA. Furthermore, traditional knowledge systems in line with conservational practices should be projected by the responsible state institutions.
Positive impact of trauma center to exsanguinating pelvic bone fracture patient survival: A Korean trauma center study
Authors: Lee Mina , Yu Byungchul , Lee Giljae , Lee Jungnam , Choi Kangkook , Park Youngeun , Gwak Jihun , Jang Myung Jin 
Published: March 2022

Background: Trauma center and multidisciplinary management protocols have been proven to improve the outcomes of severely injured patients. Hemorrhage from pelvic injury is associated with high mortality and is a common cause of preventable trauma death. This study aimed to evaluate the effects of the establishment of a trauma center and management protocols on the outcomes of hemodynamically unstable patients with pelvic fractures. Methods: Hemodynamically unstable patients with pelvic fractures were reviewed retrospectively over a 10-year period. They were grouped into the pre-phase and post-phase, which were defined as before and after the establishment of a trauma center and protocols, respectively. Basic characteristics and outcomes were compared between periods. Results: This study enrolled a total of 106 patients. Basic and physiological characteristics were not significantly different in both phases. Pre-peritoneal packing and resuscitative endovascular balloon occlusion of aorta were only performed in the post-phase (pre-peritoneal packing, N = 27; resuscitative endovascular balloon occlusion of aorta, N = 10). In the post-phase, the time from emergency department arrival to hemostatic intervention was significantly shorter (269 ± 132.4 min vs 147.2 ± 95.5 min, p < 0.0001), and mortality due to acute hemorrhage was significantly lower (p = 0.003; absolute risk reduction: 0.22; relative risk reduction: 0.72). Multivariate logistic regression analysis identified age, injury severity score, and the pre-phase as independent risk factors for mortality. Conclusion: The establishment of a trauma center and multidisciplinary management protocols, such as pre-peritoneal packing and resuscitative endovascular balloon occlusion of aorta, improved the outcomes of hemodynamically unstable patients with pelvic fractures.
KEDOP: Keratoconus early detection of progression using tomography images
Authors: Reddy Jagadesh C , Bhamidipati Panini , Dwivedi Shivam , Dhara Krishna Kishore , Joshi Vineet , Hasnat Ali Mohammad. , Vaddavalli Pravin K 
Published: March 2022

Purpose To investigate a method to identification of early progression of keratoconus using deep learning neural networks. Methods Retrospective evaluation of medical records of patients with progressive keratoconus and had more than one followup visits. Images extracted from the single scheimplug analyzer for analysis were captured during the patient visits. The baseline progression of keratoconus is detected by a change in flat or steep K of ≥1.0D which is labeled as keratometric progression (KP) and progression detected by image based deep learning convolutional neural network (CNN) models, is labeled as latent progression (LP). Patient data consisted of model data (385 eyes of 351patients) to train and test the learning models and prediction data (1331 eyes of 828 patients) to determine the LP based on the learning models. Results The LP prediction model was able to identify progression at a mean of 11.1 months earlier than KP (p < 0.001). LP prediction model was able to identify progression earlier than KP irrespective of age category, gender, the severity of keratoconus, presenting visual acuity, astigmatism, and spherical equivalent (P < 0.001). When compared to the first visit the corrected distance visual acuity was more stable in 71% of the eyes at LP prediction visit compared to 50% at KP visit (p < 0.001). Conclusion Through this study, we propose a possible solution to address the shortcomings noted in the current approaches of detecting progression relying only on KP. Avoiding bias towards feature selection from tomography images as done in the current study aids in identifying very subtle changes on the images between visits.
Seniors’ eHealth literacy, health and education status and personal health knowledge
Authors: Green Gizell 
Published: March 2022

Background The COVID-19 pandemic made eHealth literacy skills and online health activities essential for seniors. Research aims (a) To examine the differences in eHealth literacy dimensions (awareness of sources, recognizing quality and meaning, understanding information, perceived efficiency, validating information) as related to participants’ health status and education level. (b) To explore the effect of eHealth literacy dimensions on participants’ personal health knowledge. Methods We used a cross-sectional design with a convenience sample of 298 Israeli seniors aged 65 or over during the second lockdown. The questionnaire was composed of three sections: (a) background characteristics, (b) an eHealth Literacy scale, and (c) perceived personal health knowledge. Results Participants with an excellent health status reported higher levels of awareness of sources and perceived efficiency than participants with poor or good health statuses. Furthermore, participants with a graduate degree understand online information better than participants with a high school education. Moreover, it was found that participants with a high school education sense that they are being smart on the net more than participants with an undergraduate degree. Finally, we found that eHealth literacy dimensions influenced the participants’ personal health knowledge. Conclusion As the population ages, it becomes more at risk for disease, and as a result, its health status weakens. Therefore, it is important to provide seniors with appropriate intervention programs for improving their eHealth literacy, which may eliminate health inequality. In addition, caregivers need to develop patients’ eHealth literacy skills—finding, evaluation, and interpretation of online health knowledge relevant to them.
Heartache in Young Adulthood: Cross-Cultural Adaptation and Validation of a Spanish Version of the Breakup Distress Scale
Authors: Zapata-Vega Daniela , Pichardo-Marte Cynthia , Frías-Hiciano Maite , Pacheco del Castillo Laura , Espinal Jairo , Garrido Luis Eduardo 
Published: March 2022

Romantic breakups are considered one of the most stressful events experienced by young adults. Although the Breakup Distress Scale (BDS) is one of the most widely used instruments to measure breakup distress, there is limited evidence regarding its psychometric properties. Thus, we sought to adapt and validate a Spanish version of the BDS. The sample consisted of 179 Dominican young adults (78% female, 87% heterosexual, and 94% currently single), between the ages of 18 and 30 who experienced at least one breakup in the last 5 years. Parallel analysis and confirmatory factor analysis provided support for a robust one-factor structure. Additionally, the BDS scores exhibited high internal consistency reliability and item-rest correlations. Moreover, structural equation modeling indicated that those who initiated the breakup experienced less breakup distress than non-initiators, congruent with the literature. These combined findings suggest that the Spanish version of the BDS has good psychometric and validity properties.
Characteristics and Trends of Highly Cited Articles in Calcaneus Fracture Research
Authors: Goedderz Cody J. , Cantrell Colin K. , Bigach Stephen D. , Mutawakkil Muhammad Y. , Gerlach Erik B. , Butler Bennet A. , Kadakia Anish R. 
Published: March 2022

Background: Despite significant effort expended toward exploring fracture patterns, surgical timing, surgical approaches, and possible implants within the calcaneus fracture literature, treatment is still fraught with complications and controversy. This study aims to conduct a citation analysis of the most cited articles related to calcaneus fractures to highlight the most historically influential articles, as well as the more recent breakthrough articles that are leading change within the field. Methods: A literature search was performed via Scopus on September 20, 2021 using the terms “(calcaneus OR calcaneal OR hindfoot) AND (fracture OR injury)” to search “article title, abstract, and keywords” of all primary and review articles. Search results were rigorously reviewed to ensure appropriateness for this study. The 50 highest total cited included articles were analyzed. Title, authors, journal, country of origin, institution, year of publication, citation variables (total citation count, total citation density, citation count from the last 5 years, and 5-year citation density), and level of evidence were collected for each article. One-way analysis of variance with post hoc testing was used to identify differences in citation variables and level of evidence. Pearson correlation was used to directly compare different citation variables. Results: The total citation count average was 178±33, with a total citation density average of 9±2. The year of publication for the 50 articles ranged from 1948 to 2014, with a median year of 1999. Roy W. Sanders was the most productive author in the field, authoring 6 articles and lead authoring 3. The most frequent level of evidence was IV with 19 articles. There was a strong correlation between total citation density and 5-year citation density. The article level of evidence showed no impact on the included measures of an article’s influence. Conclusion: This study successfully analyzes and presents the characteristics among the highest cited articles related to calcaneus fractures. The provided characterization of influential works and authors highlights trends, impactful findings, and future areas of focus within calcaneus fracture literature. Level of Evidence: Review Article.
Sex Differences in Faculty Positions Among Top‐Ranked US Otolaryngology Departments
Authors: Pereira Nicola M. , Kacker Ashutosh 
Published: March 2022

ObjectiveThis study aims to characterize the top‐ranked departments in otolaryngology to provide an indicator of the state of diversity within otolaryngology and to draw a comparison with other medical and surgical fields.Study DesignThis cross‐sectional study examined the 20 highest‐ranked otolaryngology programs according to the US News & World Report ranking of best hospitals for ear, nose and throat.SettingAcademic otolaryngology departments in the United States.MethodsFaculty demographic and biographical data were collected from departmental websites. The Web of Science h‐index was used as a surrogate for academic productivity. Descriptive statistics and chi‐square analysis were used to characterize the cohort and compare otolaryngology with other fields.ResultsOf 562 otolaryngologists on faculty at the 20 highest‐ranked programs, 413 (73.5%) were men and 149 (26.5%) were women. Among the faculty in the cohort, 174 (31.0%) were professors, 145 (25.8%) were associate professors, and 183 (32.6%) were assistant professors. Across faculty appointments, the proportion of women grew smaller as academic rank increased. When compared with all faculty across US medical schools, the departments in this study had significantly lower proportions of female professors (P =. 0047), associate professors (P =. 0009), and assistant professors (P =. 0005). Male faculty members had higher h‐indices than their female counterparts among professors (P =. 004), associate professors (P =. 008), assistant professors (P =. 0002), and clinical assistant professors (P =. 0009).ConclusionWomen are underrepresented across all academic ranks in top‐ranked otolaryngology programs. The current state of diversity in otolaryngology yields many opportunities to advance representation for women in the field.
A study of ruxolitinib response–based stratified treatment for pediatric hemophagocytic lymphohistiocytosis
Authors: Zhang Qing , Zhao Yun-Ze , Ma Hong-Hao , Wang Dong , Cui Lei , Li Wei-Jing , Wei Ang , Wang Chan-Juan , Wang Tian-You , Li Zhi-Gang , Zhang Rui 
Published: March 2022

Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a lethal disorder characterized by hyperinflammation. Recently, ruxolitinib (RUX), targeting key cytokines in HLH, has shown promise for HLH treatment. However, there is a lack of robust clinical trials evaluating its efficacy, especially its utility as a frontline therapy. In this study (www.chictr.org.cn, ChiCTR2000031702), we designed ruxolitinib as a first-line agent for pediatric HLH and stratified the treatment based on its early response. Fifty-two newly diagnosed patients were enrolled. The overall response rate (ORR) of ruxolitinib monotherapy (day 28) was 69.2% (36/52), with 42.3% (22/52) achieving sustained complete remission (CR). All responders achieved their first response to ruxolitinib within 3 days. The response to ruxolitinib was significantly associated with the underlying etiology at enrollment (P = .009). Epstein-Barr virus (EBV)-HLH patients were most sensitive to ruxolitinib, with an ORR of 87.5% (58.3% in CR). After ruxolitinib therapy, 57.7% (30/52) of the patients entered intensive therapy with additional chemotherapy. Among them, 53.3% (16/30) patients achieved CR, and 46.7% (14/30) patients dominated by chronic active EBV infection-associated HLH (CAEBV-HLH) developed refractory HLH by week 8. The median interval to additional treatment since the first ruxolitinib administration was 6 days (range, 3-25 days). Altogether, 73.1% (38/52) of the enrolled patients achieved CR after treatment overall. The 12-month overall survival (OS) for all patients was 86.4% (95% confidence interval [CI], 77.1% to 95.7%). Ruxolitinib had low toxicity and was well tolerated compared with intensive chemotherapy. Our study provides clinical evidence for ruxolitinib as a frontline agent for pediatric HLH. The efficacy was particularly exemplified with stratified regimens based on the early differential response to ruxolitinib. This study was registered in the Chinese Clinical Trials Registry Platform (http://www.chictr.org.cn/) as ChiCTR2000031702.
Sequent periderm formation and changes in the cellular contents of phloem parenchyma during rhytidome development in Cryptomeria japonica
Authors: Ohse Megumi , Irohara Rika , Iizuka Etsushi , Arakawa Izumi , Kitin Peter , Funada Ryo , Nakaba Satoshi 
Published: March 2022

AbstractThe outer bark that includes sequent periderms is referred to as rhytidome. The defense and physiological functions of rhytidome are maintained by the continuous formation of sequent periderms. To understand the mechanisms of rhytidome growth, we examined the development of sequent periderms and the corresponding changes in the cellular contents of phloem parenchyma cells in Cryptomeria japonica. New layers of rhytidome were formed in the studied trees during the two-year course of the study. Our records showed that a new layer of periderm forms annually, and therefore, rhytidome development in C. japonica can be studied by sequential sample collection in any given year. Formation of new periderm and initiation of nuclei disappearance in phloem parenchyma in the outer layers of the developing outer bark occurred simultaneously. The early disappearance of nuclei indicates that some parenchyma cells might have been in a stage of preparation for cell death before the formation of new periderm. Four developmental stages of annual rhytidome growth were identified by structural and physiological changes of the outer layers of phloem parenchyma and the growth of the new periderm.
Enhancement in Seed Priming-Induced Starch Degradation of Rice Seed Under Chilling Stress via GA-Mediated α-Amylase Expression
Authors: Nie Lixiao , Song Shaokun , Yin Qi , Zhao Tingcheng , Liu Hongyan , He Aibin , Wang Weiqin 
Published: March 2022

AbstractChilling stress is the major abiotic stress that severely limited the seedling establishment of direct-seeded rice in temperate and sub-tropical rice production regions. While seed priming is an efficient pre-sowing seed treatment in enhancing crop establishment under abiotic stress. Our previous research has identified two seed priming treatments, selenium priming (Se) and salicylic priming (SA) that effectively improved the seed germination and seedling growth of rice under chilling stress. To further explore how seed priming enhance the starch degradation of rice seeds under chilling stress, the present study evaluated the effects of Se and SA priming on germination and seedling growth, α-amylase activity, total soluble sugar content, hormone content and associated gene relative expression under chilling stress. The results showed that both Se and SA priming significantly increased the seed germination and seedling growth attributes, and enhanced the starch degradation ability by increasing α-amylase activity and total soluble sugar content under chilling stress. Meanwhile, seed priming increased the transcription level of OsRamy1A, OsRamy3B that regulated by GA, and increased the transcription level of OsRamy3E that regulated by sugar signals. Furthermore, seed priming significantly improved the GA3 contents in rice seeds by up-regulating the expression of OsGA3ox1 and OsGA20ox1, and decreased the ABA content and the expression of OsNCED1, indicating that the improved starch degradation ability in primed rice seeds under chilling stress might be attributed to the increased GA3 and decreased ABA levels in primed rice seeds, which induced the expression of GA-mediated α-amylase. However, studies to explore how seed priming mediate hormonal metabolism and the expression of OsRamy3E are desperately needed.
Flexible ureterorenoscopy (RIRS) vs. Mini- percutaneous nephrolithotomy (MINI-PCNL) for renal stones 20–30 mm a prospective randomized study
Authors: Sebaey Ahmed , Taleb Ahmed Abou , Elbashir Salah , Gomaa Rabie , Elshazli Ali , Saber Wael 
Published: March 2022

Abstract
Background
To evaluate the safety and efficacy of mini percutaneous nephrolithotomy (mini PCNL) and retrograde intrarenal surgery (RIRS) in treatment of kidney stones 20–30 mm.

Methods
A prospective randomized study of 70 patients who presented to the urology department with calyceal or renal pelvic stone of 20–30 mm between September 2017 and September 2019. Patients were randomly divided into two groups, Group A (Mini PCNL) consists of 35 patients who were treated with mini PCNL and Group B (RIRS) consists of 35 patients who were Achieving success of the technique was considered when the patient is stone-free or has radiologically insignificant residual fragments < 4 mm.

Results
The demographic data in this study were comparable in both groups. The stone size was 20.43 ± 2.2 mm in group A & 20.5 ± 2.1 in group B, with no statistical significance. Meanwhile, the operative time in group A was 59.71 ± 19.44 min and in group B was 80.43 ± 14.79 min with statistical significance difference (p value < 0.001), while Fluoroscopy time had a mean of 8.11 ± 2.05 min in group A & 5.8 ± 1.98 min in group B with statistically significant diffrence (p value < 0.001). The stone free rate (SFR) was 88.6% in mini PCNL and 82.9% in RIRS with no statistically significant difference (p value: 0.5).

Conclusion
RIRS and mini PCNL can be an effective and alternative option for treatment of renal stones 2–3 cm. Both techniques have relatively similar SFR but RIRS showed more operative time, on contrary Mini-PCNL has more operative and postoperative complications. A multicenter studies with larger numbers of patients will be more effective to confirm these results.
Stones hounsfield unit value and predictors of urinary leakage after PCNL
Authors: Öztürk Erdem , Yıkılmaz Taha Numan , Hamidi Nurullah , Öztürk Funda Ulu , Selvi İsmail , Başar Halil , Reşorlu Berkan 
Published: March 2022

Abstract
Background
To evaluate the predictive factors of urinary leakage (UL) following percutaneous nephrolithotomy (PNL) and to investigate the relationship between Hounsfield unit (HU) of stone and UL.

Methods
We retrospectively reviewed the data of 728 patients who underwent PNL between January 2012 and January 2017. In total, 396 patients were eligible for the study. Patient demographics, renal factors, stone properties and operative details were collected. The association between UL and these variables were assessed by univariate and multivariate analysis.

Results
There was no statistically significant correlation considering age, body mass index and the presence of hypertension. The presence of diabetes mellitus (DM) was significantly correlated with UL (p < 0.001). Kidney related factors such as parenchymal thickness, hydronephrosis grade (HN), previous stone treatment, and stone related factors, such as stone surface area, stone burden, stone localization and HU value of stone, were found to affect UL status significantly (p < 0.001). Operation time, fluoroscopy time, treatment outcome, j stent use, percutenous nephrostomy (PCN) catheter stay time and the hospitalization time also had significant effect on UL (p < 0.001). Multivariable logistic analysis showed that presence of DM, parenchymal thickness, HU values, HN, operation time, j stent use, and PCN catheter stay time are independently related with UL following PCNL. Moreover, we determined a HU cut-off value of 933 with ROC analysis, which demostrated 84.9% sensitivity and 67.1% specificity for predicting UL.

Conclusion
This study has shown that we are more likely to encounter postoperative UL in stones with higher HU values. Therefore, we suggest clinicians to inform patients with this type of kidney stones about the probable complication of UL.