bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Mucositis and Salivary Nitric Oxide Levels in Patients on Radiotherapy for Head and Neck Tumors
Authors: Parize Graziele , Leão Mariella Vieira Pereira , De Souza Ingrid Rodrigues Rosa , Santos Nathaly Resende , Galhardo Luciana , Kim Yeon Jung , Resende Leonardo Diniz , França Carolina Nunes , Germano Danielle Borges , Caetano Matheus Willian , Braz-Silva Paulo Henrique , Pallos Debora 
Published: August 2022

Introduction: Mucositis has been a complication of great importance in antineoplastic treatments of head and neck tumors because when not treated properly it can lead to the interruption of radiotherapy or chemotherapy. Knowing that mucositis is a common inflammatory condition in patients undergoing radiotherapy and that nitric oxide (NO) can be a marker of inflammation.
Aim: to seek an association between mucositis, pain and NO levels in patients diagnosed with squamous cell carcinoma (SCC) in different periods of radiotherapy.
Methodology: Clinical examination was performed weekly to investigate presence of mucositis, in which the degree and intensity of pain were evaluated by using the visual analogue scale (VAS) and mouthwash samples were collected from twenty patients. In the collected samples, the concentrations of NO were measured by using the Griess method.
Results: of the twenty patients, two were excluded due to worsening of the clinical picture. Of the 18 patients who had their treatment finished, ten had some degree of mucositis and pain, with the highest levels being observed in the last week of treatment. As for the levels of NO, it was observed that low values varied widely among the patients and weeks studied. There was a statistically significant positive correlation between mucositis degrees and pain intensities, although the NO levels were correlated neither with mucositis nor with pain intensity throughout the experimental weeks.
Conclusion: Although NO is an inflammatory mediator involved in diseases of the oral cavity, its presence cannot be associated with mucositis and pain in patients with head and neck cancer who are on radiotherapy.
COVID-19 Vaccination Rates Among US Adults With Vision or Hearing Disabilities
Authors: Turner Kea , Nguyen Oliver T. , Alishahi Tabriz Amir , Islam Jessica Y. , Hong Young-Rock 
Published: August 2022

ImportanceDespite persistent care delivery inequities, limited studies have assessed COVID-19 vaccination rates among adults with vision or hearing disabilities.ObjectiveTo estimate the prevalence of and factors in COVID-19 vaccination among US adults with vision or hearing disabilities.Design, Setting, and ParticipantsThis cross-sectional study assessed data from adults who participated in the US Census Bureau Household Pulse Survey from April 2021 through March 2022. The survey assessed COVID-19 vaccine initiation, vaccine series completion, and determinants of health care access, including demographic characteristics, clinical characteristics, and social determinants of health.ExposuresVision disability (serious difficulty seeing even with eyeglasses or blindness) and hearing disability (serious difficulty hearing even with a hearing aid or deafness).Main Outcomes and MeasuresFirst dose of COVID-19 vaccine. Adjusted estimated probabilities and 95% CIs of COVID-19 vaccine initiation were calculated using multivariable logistic regression adjusted for survey week, demographic characteristics, clinical characteristics, and social determinants of health.ResultsIn this study of 916 085 US adults (weighted population, 192 719 992; mean [SD] age, 54.0 [15.9] years; 52.0% women), most participants had initiated the COVID-19 vaccine series (82.7%). Adults with serious difficulty seeing (mean difference, −6.3%; 95% CI, −7.5% to −5.1%; P &lt; .001) and blindness (mean difference, −20.1%; 95% CI, −25.1% to −15.0%; P &lt; .001) had lower vaccination rates compared with adults with little to no vision impairment. Adults with serious difficulty hearing (mean difference, −2.1%; 95% CI, −3.5% to −0.7%; P = .003) and deafness (mean difference, −17.7%; 95% CI, −21.8% to −13.6%; P &lt; .001) were less likely to initiate the COVID-19 vaccine compared with adults with little to no hearing impairment. Controlling for other factors, adults with blindness (mean difference, −6.3%; 95% CI, −11.1% to −1.5%; P = .009) were less likely to initiate the COVID-19 vaccine compared with adults with little to no vision impairment. Controlling for other factors, adults with deafness (mean difference, −5.5%; 95% CI, −9.2% to −1.9%; P = .003) were less likely to initiate the COVID-19 vaccine compared with adults with little to no hearing impairment.Conclusion and RelevanceThe findings of this cross-sectional study suggest that COVID-19 vaccine initiation is lower among adults with vision or hearing disabilities compared with adults without disabilities; this information may inform initiatives to promote equitable and accessible vaccination. Additional research may be needed to monitor COVID-19 vaccination disparities among adults with vision or hearing disabilities and to address disparities.
Family History of Psychiatric Disorders as a Risk Factor for Maternal Postpartum Depression
Authors: Zacher Kjeldsen Mette-Marie , Bricca Alessio , Liu Xiaoqin , Frokjaer Vibe G. , Madsen Kathrine Bang , Munk-Olsen Trine 
Published: August 2022

ImportanceCurrent evidence on the association between family history of psychiatric disorders and postpartum depression is inconsistent; family studies have identified familial risk of postpartum depression, whereas systematic reviews and umbrella reviews, compiling all risk factors for postpartum depression, often have not.ObjectiveTo investigate the association between family history of psychiatric disorders and risk of developing postpartum depression within 12 months post partum.Data SourcesLiterature searches were conducted in PubMed, Embase, and PsycINFO in September 2021 and updated in March 2022, accompanied by citation and reference search.Study SelectionStudies eligible for inclusion comprised peer-reviewed cohort and case-control studies reporting an odds ratio (OR) or sufficient data to calculate one for the association between family history of any psychiatric disorder and postpartum depression. Study selection was made by 2 independent reviewers: title and abstract screening followed by full-text screening.Data Extraction and SynthesisReporting was performed using the MOOSE checklist. Two reviewers independently extracted predefined information and assessed included studies for risk of bias using the Newcastle-Ottawa Scale. Data were pooled in a meta-analysis using a random-effects model. Heterogeneity was investigated with meta-regression, subgroup, and sensitivity analyses. Publication bias was investigated using a funnel plot, and GRADE (Grading of Recommendations Assessment, Development, and Evaluation) was used to evaluate the overall certainty of the findings.Main Outcomes and MeasuresThe primary outcome was the pooled association between family history of psychiatric disorders and postpartum depression.ResultsA total of 26 studies were included, containing information on 100 877 women. Meta-analysis showed an increased OR of developing postpartum depression when mothers had a family history of psychiatric disorders (OR, 2.08; 95% CI, 1.67-2.59; I2 = 57.14%) corresponding to a risk ratio of 1.79 (95% CI, 1.52-2.09), assuming a 15% postpartum depression prevalence in the general population. Subgroup, sensitivity, and meta-regression analyses were in line with the primary analysis. The overall certainty of evidence was deemed as moderate according to GRADE.Conclusions and RelevanceIn this study, there was moderate certainty of evidence for an almost 2-fold higher risk of developing postpartum depression among mothers who have a family history of any psychiatric disorder compared with mothers without.
Lactate dehydrogenase predicting mortality in patients with aneurysmal subarachnoid hemorrhage
Authors: Zan Xin , Deng Haidong , Zhang Yu , Wang Peng , Chong Weelic , Hai Yang , You Chao , Fang Fang 
Published: August 2022

AbstractObjectiveLactate dehydrogenase (LDH) has been reported to be associated with outcomes after surgery in patients with aneurysmal subarachnoid hemorrhage (aSAH), but it is unclear if this is independent from other biomarkers and across all aSAH treatments. This study aims to assess whether LDH is an independent predictor of mortality in patients with aSAH and test whether the inclusion of LDH in a well‐established prediction model can improve discrimination and reclassification.MethodsThis was a retrospective observational study at a tertiary academic medical center. This study measured baseline LDH levels taken at admission and longitudinal LDH levels (up to a month postadmission) to assess median, max, and trajectory LDH levels. The primary outcome was mortality at 90 days. Multivariable regression analyses were used to evaluate associations between LDH and outcomes. The full original Subarachnoid Hemorrhage International Trialists' (SAHIT) model was used as the reference model.ResultsIn total, 3524 patients with aSAH were included. LDH at admission was independently associated with mortality at 90 days (quartile 4 vs. 1: odds ratio 1.60; 95% CI 1.08–2.37) and mortality at the longest follow‐up (quartile 4 vs. 1: hazard ratio1.72; 95% CI 1.34–2.20). Compared with the SAHIT model, the addition of three LDH (admission, max, and median) levels to the SAHIT model significantly improved the area under the curve and categorical net reclassification improvement for prediction mortality.InterpretationIn patients with aSAH, LDH level is an independent predictor of all‐cause mortality. The incorporation of LDH into a well‐established prediction model improved the ability to predict the risk of death in patients with aSAH.
Pyroptosis Remodeling Tumor Microenvironment to Enhance Pancreatic Cancer Immunotherapy Driven by Membrane Anchoring Photosensitizer
Authors: Wang Meng , Wu Min , Liu Xingang , Shao Shiyi , Huang Junmin , Liu Bin , Liang Tingbo 
Published: August 2022

AbstractImmunotherapy, the most promising strategy of cancer treatment, has achieved promising outcomes, but its clinical efficacy in pancreatic cancer is limited mainly due to the complicated tumor immunosuppressive microenvironment. As a highly inflammatory form of immunogenic cell death (ICD), pyroptosis provides a great opportunity to alleviate immunosuppression and promote systemic immune responses in solid tumors. Herein, membrane‐targeted photosensitizer TBD‐3C with aggregation‐induced emission (AIE) feature to trigger pyroptosis‐aroused cancer immunotherapy via photodynamic therapy (PDT) is applied. The results reveal that pyroptotic cells induced by TBD‐3C could stimulate M1‐polarization of macrophages, cause maturation of dendritic cells (DCs), and activation of CD8+ cytotoxic T‐lymphocytes (CTLs). Pyroptosis‐aroused immunological responses could convert immunosuppressive “cold” tumor microenvironment (TME) to immunogenic “hot” TME, which not only inhibits primary pancreatic cancer growth but also attacks the distant tumor. This work establishes a platform with high biocompatibility for light‐controlled antitumor immunity and solid tumor immunotherapy aroused by cell pyroptosis.
A Review on CO2‐Based Polyureas and Polyurea Hybrids
Authors: Li Hui , Cheng Haiyang , Zhao Fengyu 
Published: August 2022

AbstractThe utilization of CO2as a renewable and cheap carbon resource to produce fuels, chemicals and polymers has attracted more attention. This review will summarize the developments in the production of polymers like polyureas and polyurea hybrids with CO2as a monomer directly or indirectly. The influences of catalyst and the structure of diamine monomer on the molecular weight, thermal stability and mechanical properties of polyureas are discussed. In addition, the general properties and applications of functional CO2‐based polyureas are also described. A few examples of CO2‐based polyurea hybrids are also introduced. Finally, the future research priorities as well as the development trend of polyurea materials are depicted.
Highly Diastereo‐ and Enantioselective Copper‐Catalyzed Dipropargylic Amination to Access Bispropargylic Diamines
Authors: Ma Jingbo , Wang Xinhong , Liu Zhenting , Hu Xiangping 
Published: August 2022

AbstractHerein we described the diastereo‐ and enantioselective copper‐catalyzed dipropargylic amination between propargylic acetates and diamines. The reaction features readily available substrates and broad functional group compatibility, as well as mild reaction conditions. Various synthetically valuable chiral bispropargylic diamines can be furnished in high yields with good to excellent diastereo‐ and enantioselectivities (up to 98% yield, >95 : 5 dr, >99% ee). The products further can be transformed into chiral bispropargylic diamines containing two internal alkyne groups and novel potential C2‐symmetric chiral tetraaza ligands without any loss of diastereo‐ and enantioselectivity.
Eosinophil‐derived interferon‐γ drives transmembrane protein 119–induced new bone formation in chronic rhinosinusitis with nasal polyps
Authors: Jo Sungsin , Jin Bong Joon , Lee Seung Hoon , Jo Hye‐Ryeong , Park Joo Mi , Hwang Kyung‐Gyun , Rho Mina , Kim Tae‐Hwan , Cho Seok Hyun 
Published: August 2022

AbstractBackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory sinonasal disease characterized by eosinophilic infiltration and new bone formation. These changes indicate the severity and prognosis of CRSwNP and may be closely linked to each other.MethodsWe performed RNA sequencing to screen specific osteogenic molecules and validated transmembrane protein 119 (TMEM119) expression by quantitative polymerase chain reaction (qPCR) and immunohistochemistry analyses. TMEM119 knockdown was performed to observe the downregulation of bone mineralization. We validated the bone‐forming activity of interferon‐γ (IFN‐γ) and its signaling pathways in cultured primary sinus bone cells. Cellular sources of IFN‐γ were identified using immunohistochemistry and immunofluorescence analyses. Interleukin‐4–eosinophil–IFN‐γ axis and the effect of dupilumab were investigated in Eol‐1 cells.ResultsWe observed elevated IFN‐γ levels and eosinophils in the nasal fluid and predominantly eosinophil‐derived IFN‐γ in the sinus mucosa of patients with CRSwNP. TMEM119 expression and bone‐forming activities were increased in the osteitic and primary sinus bone cells of CRSwNP. IFN‐γ treatment enhanced bone mineralization and TMEM119 expression via signal transducer and activator of transcription 1 (STAT1) signaling. Moreover, TMEM119 knockdown inhibited sinus bone cell mineralization and dupilumab attenuated IFN‐γ secretion by IL4‐stimulated Eol‐1 cells.ConclusionEosinophil‐derived IFN‐γ promotes the bone‐forming activities of sinus bone cells via the STAT1–TMEM119 signaling pathway. Interleukin‐4–eosinophil–IFN‐γ axis may be crucial for TMEM119‐mediated new bone formation in CRSwNP.
De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission
Authors: Platzer Konrad , Sticht Heinrich , Bupp Caleb , Ganapathi Mythily , Pereira Elaine M. , Le Guyader Gwenaël , Bilan Frederic , Henderson Lindsay B. , Lemke Johannes R. , Taschenberger Holger , Brose Nils , Abou Jamra Rami , Wojcik Sonja M. 
Published: August 2022

ObjectiveRare inherited missense variants in SLC32A1, the gene that encodes the vesicular gamma‐aminobutyric acid (GABA) transporter, have recently been shown to cause genetic epilepsy with febrile seizures plus. We aimed to clarify if de novo missense variants in SLC32A1 can also cause epilepsy with impaired neurodevelopment.MethodsUsing exome sequencing, we identified four individuals with a developmental and epileptic encephalopathy and de novo missense variants in SLC32A1. To assess causality, we performed functional evaluation of the identified variants in a murine neuronal cell culture model.ResultsThe main phenotype comprises moderate‐to‐severe intellectual disability, infantile‐onset epilepsy within the first 18 months of life, and a choreiform, dystonic, or dyskinetic movement disorder. In silico modeling and functional analyses reveal that three of these variants, which are located in helices that line the putative GABA transport pathway, result in reduced quantal size, consistent with impaired filling of synaptic vesicles with GABA. The fourth variant, located in the vesicular gamma‐aminobutyric acid N‐terminus, does not affect quantal size, but increases presynaptic release probability, leading to more severe synaptic depression during high‐frequency stimulation. Thus, variants in vesicular gamma‐aminobutyric acid can impair GABAergic neurotransmission through at least two mechanisms, by affecting synaptic vesicle filling and by altering synaptic short‐term plasticity.InterpretationThis work establishes de novo missense variants in SLC32A1 as a novel cause of a developmental and epileptic encephalopathy.Summary for Social Media If Published
@platzer_k @lemke_johannes @RamiJamra @Nirgalito @GeneDx
The SLC family 32 Member 1 (SLC32A1) is the only protein identified to date, that loads gamma‐aminobutyric acid (GABA) and glycine into synaptic vesicles, and is therefore also known as the vesicular GABA transporter (VGAT) or vesicular inhibitory amino acid transporter (VIAAT). Rare inherited missense variants in SLC32A1, the gene that encodes VGAT/vesicular inhibitory amino acid transporter, have recently been shown to cause genetic epilepsy with febrile seizures plus.
We aimed to clarify if de novo missense variants in SLC32A1 can also cause epilepsy with impaired neurodevelopment.
We report on four individuals with de novo missense variants in SLC32A1 and a developmental and epileptic encephalopathy with infantile onset epilepsy. We establish causality of the variants via in silico modeling and their functional evaluation in a murine neuronal cell culture model.
SLC32A1 variants represent a novel genetic etiology in neurodevelopmental disorders with epilepsy and a new GABA‐related disease mechanism.
ANN NEUROL 2022;92:958–973
Pas de Deux of an NO Couple: Synchronous Photoswitching from a Double‐Linear to a Double‐Bent Ru(NO)2 Core under Nitrosyl Charge Conservation
Authors: Hasil Asma , Beck Daniel , Schröder Daniel , Pillet Sébastien , Wenger Emmanuel , Woike Theo , Klüfers Peter , Schaniel Dominik 
Published: August 2022

AbstractThe {Ru(NO)2}10 dinitrosylruthenium complex [Ru(NO)2(PPh3)2] (1) shows photo‐induced linkage isomerism (PLI) of a special kind: the two NO ligands switch, on photo‐excitation, synchronously from the ground state (GS) with two almost linear RuNO functions to a metastable state (MS) which persists up to 230 K and can be populated to ≈50 %. The MS was experimentally characterised by photo‐crystallography, IR spectroscopy and DS‐calorimetry as a double‐bent variant of the double‐linear GS. The experimental results are confirmed by computation which unravels the GS/MS transition as a disrotatory synchronous 50° turn of the two nitrosyl ligands. Although 1 shows the usual redshift of the N−O stretch on bending the MNO unit, there is no increased charge transfer from Ru to NO along the GS‐to‐MS path. In terms of the effective‐oxidation‐state (EOS) method, both isomers of 1 and the transition state are Ru−II(NO+)2 species.
A large non‐marine turtle from the Upper Cretaceous of Alabama and a review of North American “Macrobaenids”
Authors: Gentry Andrew D. , Kiernan Caitlín R. , Parham James F. 
Published: August 2022

AbstractThe abundant record of marine turtles from the Late Cretaceous of Appalachia contrasts with the relatively poor record of contemporaneous terrestrial and freshwater species. A new taxon from the Santonian‐Campanian of Alabama,Appalachemys ebersoleigen. et sp. nov., is described here and assigned to a grade of freshwater turtles known as “macrobaenids.”Appalachemyscan be differentiated from other “macrobaenids” by the presence of a nearly round carapace, deep nuchal emargination, and nine pairs of costals. With a carapace more than 80 cm in length,Appalachemysis among the largest freshwater turtles to ever inhabit North America. The absence of pre‐Campanian “macrobaenids” from Laramidia indicates that the North American distribution of this grade may have been restricted to Appalachia prior to the recession of the Western Interior Seaway. Phylogenetic analysis placesAppalachemysas the sister taxon to all post‐Santonian “macrobaenids.” Although the phylogeny lacks statistical support, it demonstrates morphological similarities between the K/Pg boundary speciesOsteopygis emarginatusand Maastrichtian‐Danian species referred toJudithemys. We, therefore, refer all but the Campanian type species ofJudithemysto the genusOsteopygis. A review of all North American “macrobaenid” occurrences reveals that despite originating in Asia, the record of the grade (as defined here) is predominantly North American. Future studies can test whether late Paleocene records in Asia and Europe resulted from dispersal from North America.
Effect of operating conditions on the hydrothermal valorization of sewage sludge
Authors: Madikizela Mbaliyezwe , Isa Yusuf Makarfi 
Published: August 2022

AbstractThis study followed a quantitative approach, with the purpose of converting municipal sewage to valuable bio‐oils. The sewage sludge was subjected to hydrothermal liquefaction in 60 mL stainless steel batch reactors, where the effects of temperature, solvent composition and solvent content were investigated, and all the other process parameters were maintained at constant values. Temperatures were explored between 220 and 370°C. The two solvents investigated were de‐ionized water (H2O) and ethanol (E) which were applied in the following compositions: 1:0, 1:1 and 0:1 (H2O:E). The five solvent contents (moisture contents) investigated were 75, 80, 85, 90 and 95 wt%. The temperature of 310°C emerged categorically as the optimal temperature across the various solvent contents. The best yield was achieved when H2O/E (1:1) performed as a co‐solvent at 85% solvent content and 310°C, which amounted to 40.69 wt%. Bio‐oils derived by the use of pure H2O solvent were overall the least effective in yielding high bio‐oil quantities. The lowest bio‐oil yield obtained was 6.42 wt% where pure H2O was the solvent at extreme conditions of 370°C and 95% solvent content. The order of efficiency of solvent content was as follows: 85% > 80% > 75% > 90% > 95%. Among the six temperatures investigated, the intermediate temperature, 310°C, gave the highest conversions. The highest conversion across all of the runs was 85.65% at 310°C with 90% solvent content using the co‐solvent H2O/E. The order of superiority of solvent was H2O/E > pure ethanol > pure water. © 2022 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.
Nanoparticle‐based single molecule fluorescent probes
Authors: Chen Xueqian , Liu Yuhao , Liu Xiaoting , Lu Chao 
Published: August 2022

AbstractSingle molecule fluorescent probes have attracted considerable attention due to their ultimate sensitivity, fast response, low sample consumption, and high signal‐to‐noise ratio. Nanoparticles with outstanding optical properties make them perfect candidates for probes in the application of single molecule detection. In this review, we focus on various kinds of nanoparticles acting as single molecule fluorescent probes, including quantum dots, upconverting fluorescent nanoparticles, carbon dots, single‐wall carbon nanotubes, fluorescent nanodiamonds, polymeric nanoparticles, nanoclusters, and metallic nanoparticles. Optical properties of various nanoparticles and their recent application in single molecule fluorescent probes are explored. How nanoparticles boost the sensitivity of detection is emphasized in combination with different sensing strategies. Future trends of nanoparticles in single molecule detection are also discussed. We hope that this review can provide practical guidance for researchers who work on nanoparticle‐based single molecule fluorescent probes.