bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of dapagliflozin on the prognosis of patients with acute myocardial infarction undergoing percutaneous coronary intervention
Authors: Zhu Yi , Zhang Jia-li , Yan Xue-jiao , Sun Ling , Ji Yuan , Wang Fang-fang 
Published: September 2022

Abstract
Background and aims
The effect of dapagliflozin (DAPA) on the prognosis of patients with acute myocardial infarction (AMI) is unclear. The present study was conducted to evaluate the association between DAPA administration and adverse events in patients with AMI undergoing percutaneous coronary intervention (PCI).

Methods
This single-center retrospective analysis study included a total of 786 patients with AMI from January 2019 to August 2021 who were or were not administered DAPA at discharge. The primary endpoint was the composite of major adverse cardiovascular events (MACE), including overall deaths, heart failure, nonfatal MI, nonfatal stroke, and unplanned repeat revascularization (URR). Differences in the triglyceride glucose (TyG) index and the atherogenic index of plasma (AIP) both during hospitalization and 12 months after discharge (if achievable) were also compared.

Results
During a median follow-up of 23 months, 130 patients had MACE (118 in the DAPA-free group and 12 in the DAPA group). Kaplan–Meier survival analyses revealed that the cumulative incidence of MACE (log-rank test, p = 0.009), heart failure (p = 0.003), nonfatal MI (p = 0.005), and URR (p = 0.031) was higher in the DAPA-free group. In addition, the multivariate Cox analysis showed that DAPA was significantly associated with the reduced risk of MACE (hazard ratio = 0.170, 95% confidence interval = 0.078–0.373, p < 0.001). Considering each specific adverse event, the DAPA-free group was associated with heart failure, nonfatal MI, and URR in multivariate Cox regression analyses. Stratification analyses suggested that DAPA has a strong protective effect in patients with AMI of advanced age with concomitant diabetes or those who are not on angiotensin receptor enkephalinase inhibitors. Furthermore, the TyG index and AIP of the patients 12 months after DAPA administration at discharge were significantly lower than those during hospitalization.

Conclusions
DAPA is an independent protective factor against MACE and may provide incremental prognostic information in patients with AMI undergoing PCI.
Dietary and drinking water intake of essential trace elements in a typical Kashin-Beck disease endemic area of Tibet, China
Authors: Zha Xinjie , An Jialu , Gao Xue , Tian Yuan 
Published: September 2022

Abstract
Background
Essential trace elements (ETEs), such as copper (Cu), iron (Fe), manganese (Mn), molybdenum (Mo), selenium (Se), zinc (Zn), are very important elements for human health.

Methods
In this study, 89 drinking water samples and 85 highland barleys were collected from 48 villages in 11 townships, and the average daily dose (ADD) of ETEs were calculated, in addition, health effects of ETEs to rural residents in Luolong County, a typical Kashin-Beck disease (KBD) endemic area in Tibet, were assessed.

Results
The mean concentrations of Cu, Fe, Mn, Mo, Se, Zn in drinking water were 0.278 ± 0.264 μg·kg−1, 0.766 ± 0.312 μg·kg−1, 0.411 ± 0.526 μg·kg−1, 0.119 ± 0.223 μg·kg−1, 0.155 ± 0.180 μg·kg−1, and 0.804 ± 1.112 μg·kg−1, respectively; and mean concentrations of Cu, Fe, Mn, Mo, Se and Zn in highland barley were 3.550 ± 0.680 mg·kg−1, 81.17 ± 38.14 mg·kg−1, 14.03 ± 1.42 mg·kg−1, 0.350 ± 0.200 mg·kg−1, 0.0028 ± 0.0056 mg·kg−1, and 23.58 ± 3.10 mg·kg−1, respectively. The ADD of Cu in the study area was appropriate; the ADD of Fe and Mn in each township were higher than the maximum oral reference dose recommended by the National Health Commission of China, indicating that Fe and Mn had non-carcinogenic health risks; the ADD of Mo and Zn in 36.36% and 54.55% of the townships exceeded the maximum oral reference dose; and 72.73% of the townships had insufficient ADD of Se. The ADD of Mo, Cu and Se in different townships was significantly correlated with the prevalence of KBD.

Conclusions
Therefore, in order to prevent and control the prevalence of KBD and ensure the health of local residents, it is necessary to reduce the intake of high concentrations of Fe, Mn and Zn in diet, as well as increase the intake of Mo, Cu, especially Se.

Graphical abstract
Alcohol-dependent downregulation of apolipoprotein H exacerbates fatty liver and gut microbiota dysbiosis in mice
Authors: Liu Yaming , Wu Zhe , Zhang Yong , Chen Binbin , Yu Shuqi , Li Wanyun , Ren Jianlin 
Published: September 2022

Abstract
Background
Alcohol-related liver disease (ALD) is a major chronic liver ailment caused by alcohol overconsumption and abuse. Apolipoprotein H (APOH) participates in lipid metabolism and might have a potential regulatory role in ALD. Therefore, this study aimed to explore the effects of ApoH on alcohol-induced liver injury and gut microbiota dysbiosis.

Methods
ApoH−/− mice were generated and the synergic alcoholic steatohepatitis mouse model was constructed, which were used to assess liver function and pathological changes.

Results
ApoH−/− mice clearly exhibited spontaneous steatohepatitis. Severe hepatic steatosis was observed in alcohol-fed WT and ApoH−/− mice, in which ApoH expression was reduced post alcohol consumption. Moreover, RNA-seq and KEGG pathway analyses indicated that differential expression genes enriched in lipid metabolism and oxidation–reduction process between in alcohol-fed ApoH−/− mice and pair-fed control mice. Finally, gut microbiota diversity and composition were assessed by 16S rRNA Illumina next-generation sequencing. Alpha diversity of enterobacteria was lower in ApoH−/− mice with ethanol feeding than in ethanol-fed WT mice and all control-fed mice (P < 0.05). Moreover, KEGG enrichment analysis, using PICRUSt software, revealed that metabolic functions were activated in the gut microorganisms of ApoH−/− mice with ethanol feeding (P < 0.05).

Conclusions
Alcohol-downregulated ApoH expression, leading to the progress of fatty liver disease and gut microbiota dysbiosis.
The clinicopathological and prognostic factors of hepatocellular carcinoma: a 10-year tertiary center experience in Egypt
Authors: Sweed Dina , Sweed Enas , Moaz Inas , Mosbeh Asmaa , Fayed Yahya , Elhamed Sara Mohamed Abd , Sweed Eman , Macshut Mahmoud , Abdelsattar Shimaa , Kilany Shimaa , Saied Sara A. , Badr Reda , Abdallah Mahmoud S. , Ehsan Nermine 
Published: September 2022

AbstractBackgroundHepatocellular carcinoma (HCC) remains a major health problem despite the emergence of several preventive and therapeutic modalities. HCC has heterogeneous and wide morpho-molecular patterns, resulting in unique clinical and prognostic criteria. Therefore, we aimed to study the clinical and pathological criteria of HCC to update the morpho-molecular classifications and provide a guide to the diagnosis of this disease.MethodsFive hundred thirty pathologically analyzed HCC cases were included in this study. The clinical and survival data of these cases were collected.ResultsHepatitis C virus is still the dominant cause of HCC in Egypt. Post-direct-acting antiviral agent HCC showed an aggressive course compared to interferon-related HCC. Old age, male gender, elevated alpha-fetoprotein level, tumor size, and background liver were important prognostic parameters. Special HCC variants have characteristic clinical, laboratory, radiological, prognostic, and survival data. Tumor-infiltrating lymphocytes rather than neutrophil-rich HCC have an excellent prognosis.ConclusionsHCC is a heterogenous tumor with diverse clinical, pathological, and prognostic parameters. Incorporating the clinicopathological profile per specific subtype is essential in the treatment decision of patients with HCC.Trial registrationThis was a retrospective study that included 530 HCC cases eligible for analysis. The cases were obtained from the archives of the Pathology Department, during the period between January 2010 and December 2019. Clinical and survival data were collected from the patients’ medical records after approval by the institutional review board (IRB No. 246/2021) of Liver National Institute, Menoufia University. The research followed the guidelines outlined in the Declaration of Helsinki and registered on ClinicalTrials.gov (NCT05047146).
A systematic review of the economic evaluations of Enzyme Replacement Therapy in Lysosomal Storage Diseases
Authors: Katsigianni Eleni Ioanna , Petrou Panagiotis 
Published: September 2022

Abstract
Objective
The objective of this paper is to assess the economic profile of Enzyme Replacement Therapy (ERT) to symptomatic patients with Pompe, Fabry, Gaucher disease and Lysosomal acid lipase (LAL) deficiency.

Methods
A systematic search was performed to retrieve and critically assess economic evaluations of enzyme replacement therapy. Publications were screened according to predefined criteria and evaluated according to the Quality of Economic Studies. Data were narratively synthesized.

Results
The Incremental Cost-Effectiveness Ratio greatly exceeded willingness to pay thresholds. The cost of the medication dominated the sensitivity analysis. For Infantile-onset Pompe’s disease, the incremental cost-effectiveness ratio (ICER) was estimated at €1.043.868 per Quality-adjusted life year (QALY) based on the dose of alglucosidase 40 mg/kg/ week, and €286.114 per QALY for 20 mg of alglucosidase/kg/2 weeks. For adults patients presenting with Pompe disease the reported was ICER € 1.8 million/ QALY. In the case of Fabry disease, the ICER per QALY amounts to 6.1 million Euros/QALY. Respectively for Gaucher’s disease, the ICER /QALY was estimated at € 884,994 per QALY. Finally, for patients presenting LAL deficiency NCPE perpetuated an ICER of €2,701,000/QALY.

Discussion
ERT comprise a promising treatment modality for orphan diseases; nevertheless, it is interlaced with a substantial economic burden. Moreover, the available data on the cost-effectiveness ratio are scarce. For certain diseases, such as Fabry, a thorough selection of patients could exert a beneficial effect on the reported ICER. Steep price reductions are imperative for these products, in the conventional reimbursement pathway or a new assessment framework should be elaborated, which in principle, should target uncertainty.
The role of DNA demethylation in liver to pancreas transdifferentiation
Authors: Har-Zahav Adi , Lixandru Daniela , Cheishvili David , Matei Ioan Valentin , Florea Ioana Raluca , Aspritoiu Veronica Madalina , Blus-Kadosh Inna , Meivar-Levy Irit , Serban Andreea Madalina , Popescu Irinel , Szyf Moshe , Ferber Sarah , Dima Simona Olimpia 
Published: September 2022

Abstract
Background
Insulin producing cells generated by liver cell transdifferentiation, could serve as an attractive source for regenerative medicine. The present study assesses the relationship between DNA methylation pTFs induced liver to pancreas transdifferentiation.

Results
The transdifferentiation process is associated with DNA demethylation, mainly at gene regulatory sites, and with increased expression of these genes. Active inhibition of DNA methylation promotes the pancreatic transcription factor-induced transdifferentiation process, supporting a causal role for DNA demethylation in this process.

Conclusions
Transdifferentiation is associated with global DNA hypomethylation, and with increased expression of specific demethylated genes. A combination of epigenetic modulators may be used to increase chromatin accessibility of the pancreatic transcription factors, thus promoting the efficiency of the developmental process.
Sex at the interface: the origin and impact of sex differences in the developing human placenta
Authors: Braun Amy E. , Mitchel Olivia R. , Gonzalez Tania L. , Sun Tianyanxin , Flowers Amy E. , Pisarska Margareta D. , Winn Virginia D. 
Published: September 2022

AbstractThe fetal placenta is a source of hormones and immune factors that play a vital role in maintaining pregnancy and facilitating fetal growth. Cells in this extraembryonic compartment match the chromosomal sex of the embryo itself. Sex differences have been observed in common gestational pathologies, highlighting the importance of maternal immune tolerance to the fetal compartment. Over the past decade, several studies examining placentas from term pregnancies have revealed widespread sex differences in hormone signaling, immune signaling, and metabolic functions. Given the rapid and dynamic development of the human placenta, sex differences that exist at term (37–42 weeks gestation) are unlikely to align precisely with those present at earlier stages when the fetal–maternal interface is being formed and the foundations of a healthy or diseased pregnancy are established. While fetal sex as a variable is often left unreported in studies performing transcriptomic profiling of the first-trimester human placenta, four recent studies have specifically examined fetal sex in early human placental development. In this review, we discuss the findings from these publications and consider the evidence for the genetic, hormonal, and immune mechanisms that are theorized to account for sex differences in early human placenta. We also highlight the cellular and molecular processes that are most likely to be impacted by fetal sex and the evolutionary pressures that may have given rise to these differences. With growing recognition of the fetal origins of health and disease, it is important to shed light on sex differences in early prenatal development, as these observations may unlock insight into the foundations of sex-biased pathologies that emerge later in life.
Bioprospecting endophytic fungi for antifeedants and larvicides and their enhancement by gamma irradiation
Authors: Hazaa Magdia A. , Shebl Magdy M. , El-Sayed El-Sayed R. , Mahmoud Samar R. , Khattab Abeer A. , Amer Mahmoud M. 
Published: September 2022

AbstractThe search and discovery of new natural products with antifeedant and larvicidal potentials to mitigate harmful insects are scientific pressing issues in the modern agriculture. In this paper, the antifeedant and larvicidal potentials of 69 fungal isolates were screened against the Egyptian cotton leafworm Spodoptera littoralis. A total of 17 isolates showed the insecticidal potentials with three promising isolates. These strains were Aspergillus sydowii, Lasiodiplodia theobromae, and Aspergillus flavus isolated from Ricinus communis (bark), Terminalia arjuna (Bark), and Psidium guajava (twigs), respectively. The effect of gamma irradiation on the antifeedant and larvicidal activities of the three strains was investigated. Exposure of the fungal spores to 1000 Gy of gamma rays significantly intensified both the antifeedant and larvicidal potentials. To identify compounds responsible for these activities, extracts of the three strains were fractionated by thin layer chromatography. The nature of the separated compounds namely, Penitrem A, 1, 3, 5, 8- tetramethyl- 4, 6-diethyl- 7- [2- (methoxycarbonyl)ethyl] porphyrin (from A. sydowii), Penitrem A, 2, 7, 12, 17-Tetramethyl-3, 5:8, 10:13, 15:18, 20-tetrakis (2,2-dimethylpropano) porphyrin (from A. flavus), N,N-Diethyl-3-nitrobenzamide, and Diisooctyl-phthalate (from L. theobromae) were studied by GC-MS analysis. These findings recommend endophytic fungi as promising sources of novel natural compounds to mitigate harmful insects.
Comparison of semi-supervised deep learning algorithms for audio classification
Authors: Cances Léo , Labbé Etienne , Pellegrini Thomas 
Published: September 2022

AbstractIn this article, we adapted five recent SSL methods to the task of audio classification. The first two methods, namely Deep Co-Training (DCT) and Mean Teacher (MT), involve two collaborative neural networks. The three other algorithms, called MixMatch (MM), ReMixMatch (RMM), and FixMatch (FM), are single-model methods that rely primarily on data augmentation strategies. Using the Wide-ResNet-28-2 architecture in all our experiments, 10% of labeled data and the remaining 90% as unlabeled data for training, we first compare the error rates of the five methods on three standard benchmark audio datasets: Environmental Sound Classification (ESC-10), UrbanSound8K (UBS8K), and Google Speech Commands (GSC). In all but one cases, MM, RMM, and FM outperformed MT and DCT significantly, MM and RMM being the best methods in most experiments. On UBS8K and GSC, MM achieved 18.02% and 3.25% error rate (ER), respectively, outperforming models trained with 100% of the available labeled data, which reached 23.29% and 4.94%, respectively. RMM achieved the best results on ESC-10 (12.00% ER), followed by FM which reached 13.33%. Second, we explored adding the mixup augmentation, used in MM and RMM, to DCT, MT, and FM. In almost all cases, mixup brought consistent gains. For instance, on GSC, FM reached 4.44% and 3.31% ER without and with mixup. Our PyTorch code will be made available upon paper acceptance at https://github.com/Labbeti/SSLH.
CLQLMRS: improving cache locality in MapReduce job scheduling using Q-learning
Authors: Ghazali Rana , Adabi Sahar , Rezaee Ali , Down Douglas G. , Movaghar Ali 
Published: September 2022

AbstractScheduling of MapReduce jobs is an integral part of Hadoop and effective job scheduling has a direct impact on Hadoop performance. Data locality is one of the most important factors to be considered in order to improve efficiency, as it affects data transmission through the system. A number of researchers have suggested approaches for improving data locality, but few have considered cache locality. In this paper, we present a state-of-the-art job scheduler, CLQLMRS (Cache Locality with Q-Learning in MapReduce Scheduler) for improving both data locality and cache locality using reinforcement learning. The proposed algorithm is evaluated by various experiments in a heterogeneous environment. Experimental results show significantly decreased execution time compared with FIFO, Delay, and the Adaptive Cache Local scheduler.
Prevalence of adequate postnatal care and associated factors in Rwanda: evidence from the Rwanda demographic health survey 2020
Authors: Kawuki Joseph , Gatasi Ghislaine , Sserwanja Quraish 
Published: September 2022

Abstract
Background
Although quality postnatal care (PNC) is a known significant intervention for curbing maternal and newborn morbidity and mortality, it is underutilized in most developing countries including Rwanda. Thus, it is crucial to identify factors that facilitate or occlude receipt of adequate PNC. This study aimed at assessing the prevalence of adequate PNC content and the associated factors in Rwanda.

Methods
We used weighted data from the Rwanda Demographic and Health Survey (RDHS) of 2020, comprising of 4456 women aged 15–49 years, who were selected using multistage sampling. Adequate PNC was considered if a woman had received all of the five components; having the cord examined, temperature of the baby measured, counselling on newborn danger signs, counselling on breastfeeding and having an observed breastfeeding session. We, then, conducted multivariable logistic regression to explore the associated factors, using SPSS version 25.

Results
Out of the 4456 women, 1974 (44.3, 95% confidence interval (CI): 43.0–45.9) had received all the PNC components. Having no radio exposure (adjusted odds ratio (AOR) =1.41, 95% CI: 1.18–1.68), visited by a fieldworker (AOR = 1.35, 95% CI: 1.16–1.57), no big problem with distance to a health facility (AOR = 1.50, 95% CI:1.24–1.81), and residing in the Southern region (AOR = 1.75, 95% CI: 1.42–2.15) were associated with higher odds of adequate PNC compared to their respective counterparts. However, having no exposure to newspapers/magazines (AOR = 0.74, 95% CI: 0.61–0.89), parity of less than 2 (AOR = 0.67, 95% CI: 0.51–0.86), being a working mother (AOR = 0.73, 95% CI: 0.62–0.85), no big problem with permission to seek healthcare (AOR = 0.54, 95% CI: 0.36–0.82), antenatal care (ANC) frequency of less than 4 times (AOR = 0.79, 95% CI: 0.62–0.85), inadequate ANC quality (AOR = 0.56, 95% CI: 0.46–0.68), and getting ANC in a public facility (AOR = 0.57, 95% CI: 0.38–0.85) were associated with lower odds of adequate PNC.

Conclusions
Less than half of the mothers in Rwanda had received adequate PNC, and this was associated with various factors. The results, thus, suggested context-specific evidence for consideration when rethinking policies to improve adequate PNC, including a need for intensified PNC education and counselling during ANC visits, continued medical education and training of PNC providers, and strengthening of maternal leave policies for working mothers.
Willingness to share information for energy efficiency: exploring differences and drivers across the Nordic countries
Authors: Reyes Joseph Anthony L. 
Published: September 2022

Abstract
Background
There is growing attention and policy debate about the sharing of personal information that the modernization of electricity grids requires. This is particularly important for big data management in smart grids that needs access to data generated and sent through devices such as smart meters. Using the Nordic Countries as a case study, this study investigates the willingness of people to share personal information for energy efficiency. The study builds upon data from the Eurobarometer survey and binary logistic regressions.

Results
Nordic countries exhibit a higher willingness to share personal information compared to the rest of the EU countries. However, despite high levels of concern for climate change and other pro-environmental attitudes found overall among Europeans, the willingness to share personal information is not as prevalent and is still mainly shaped by socio-demographic features such as gender and age. Key predictors also included climate change perception and congruence of citizen engagement with environmentally friendly behaviors. Several contextual and market-specific issues framing these findings are discussed (e.g., trust, energy use).

Conclusions
Even when high levels of pro-environmental attitudes in certain countries are found, let alone the Nordics, this does not mean people are willing to share personal information that would support pro-environmental energy efficiency behaviors and policies.