bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Visualized Dynamic Prediction Model for Lymphatic Metastasis in Ewing's Sarcoma for Smart Medical Services
Authors: Li Wenle , Xu Chan , Hu Zhaohui , Dong Shengtao , Wang Haosheng , Liu Qiang , Tang Zhi-Ri , Li Wanying , Wang Bing , Lei Zhi , Yin Chengliang 
Published: May 2022

BackgroundThis study aims to predict the lymphatic metastasis in Ewing's sarcoma (ES) patients by nomogram. The risk of lymphatic metastasis in patients with ES was predicted by the built model, which provided guidance for the clinical diagnosis and treatment planning.MethodsA total of 929 patients diagnosed with ES were enrolled from the year of 2010 to 2016 in the Surveillance, Epidemiology, and End Results (SEER) database. The nomogram was established to determine predictive factors of lymphatic metastasis according to univariate and multivariate logistic regression analysis. The validation of the model performed using multicenter data (n = 51). Receiver operating characteristics (ROC) curves and calibration plots were used to evaluate the prediction accuracy of the nomogram. Decision curve analysis (DCA) was implemented to illustrate the practicability of the nomogram clinical application. Based on the nomogram, we established a web calculator to visualize the risk of lymphatic metastases. We further plotted Kaplan-Meier overall survival (OS) curves to compare the survival time of patients with and without lymphatic metastasis.ResultsIn this study, the nomogram was established based on six significant factors (survival time, race, T stage, M stage, surgery, and lung metastasis), which were identified for lymphatic metastasis in ES patients. The model showed significant diagnostic accuracy with the value of the area under the curve (AUC) was 0.743 (95%CI: 0.714–0.771) for SEER internal validation and 0.763 (95%CI: 0.623–0.871) for multicenter data external validation. The calibration plot and DCA indicated that the model had vital clinical application value.ConclusionIn this study, we constructed and developed a nomogram with risk factors to predict lymphatic metastasis in ES patients and validated accuracy of itself. We found T stage (Tx OR = 2.540, 95%CI = 1.433–4.503, P &lt; 0.01), M stage (M1, OR = 2.061, 95%CI = 1.189–3.573, P &lt; 0.05) and survival time (OR = 0.982, 95%CI = 0.972–0.992, P &lt; 0.001) were important independent factors for lymphatic metastasis in ES patients. Furthermore, survival time in patients with lymphatic metastasis or unclear situation (P &lt; 0.0001) was significantly lower. It can help clinicians make better decisions to provide more accurate prognosis and treatment for ES patients.
COVID-19 Mobile Health Apps: An Overview of Mobile Applications in Indonesia
Authors: Sujarwoto Sujarwoto , Augia Trisfa , Dahlan Hendery , Sahputri Rindi Ardika Melsalasa , Holipah Holipah , Maharani Asri 
Published: May 2022

BackgroundMobile health applications (mHealth apps) have been widely used for various purposes for mitigating the COVID-19 pandemic, such as self-assessment, contact tracing, disseminating information, minimizing exposure, and reducing face-to-face health consultation. The objective of this study is to systematically review COVID-19 related mHealth apps and highlight gaps to inform the development of future mHealth initiatives in Indonesia.MethodsA systematic search strategy using a PRISMA flowchart was used to identify mHealth apps available in Google Play and Apple Play stores. We searched mHealth apps using certain specific terms related to COVID-19 outbreaks. The inclusion criteria were apps-based smartphone users related to COVID-19 using local language, free of cost, available in the Google Play and Apple Play Stores, and supported by the Indonesian government. We excluded games, apps on infectious diseases unrelated to COVID-19 specifically, and apps with non-Bahasa Indonesia (Indonesian language). The selected mHealth apps were assessed based on two measures: (1) the WHO guidelines on digital health intervention and (2) the four dimensions of the mHealth technology fit framework. In addition, user feedback from experienced and non-experienced users was conducted to evaluate four dimensions of the apps.ResultsA total of 339 mHealth apps were generated from the initial search, remaining seven selected apps that met inclusion criteria. The results highlighted that mHealth apps reviewed had still not been widely used by the general public. The applications were purposed to disseminate information, conduct a self-risk assessment, provide an online community forum, and telemedicine or teleconsultation regarding COVID-19. Data services, including data storage, aggregation, and data exchange, are available in most apps. The rarest function found was contact tracing and assisting health management and health workers, such as the availability of testing facilities, reporting test results, and prescribing medication. The main issues reported were the lack of data security and data privacy protection, integration and infrastructures, usability, and usefulness.ConclusionOur study highlighted the necessity to improve mHealth apps' functions related to assisting health workers and the function of digital contact tracing. An effort to increase public awareness regarding the use of mHealth is also necessary to streamline the function of this innovation. Policymakers must consider usefulness, usability, integration, and infrastructure issues to improve their mHealth function.
Associations Between Online Learning, Smartphone Addiction Problems, and Psychological Symptoms in Chinese College Students After the COVID-19 Pandemic
Authors: Zhang Chi , Hao Jinjuan , Liu Ye , Cui Ju , Yu Hao 
Published: May 2022

BackgroundSmartphone-based online education gained popularity during and after the COVID-19 pandemic. Although recent studies have highlighted the association between problematic smartphone use (PSU) and mental health symptoms, the potential role of online learning in this relationship remains unclear. This study aimedto analyze the relationships between higher education modes, PSU, and related psychological symptoms in university students.MethodsA total of 1,629 Chinese university students from five provinces completed a web-based questionnaire survey between March 2020 and October 2021. Demographic characteristics and learning conditions were recorded. All participants completed the Smartphone Addiction Scale-Short Version, Patient Health Questionnaire, Generalized Anxiety Disorder Scale, and Athens Insomnia Scale. Multiple regressions models and stratified analyses were used to examine the association between online education mode, PSU, and symptoms of depression, anxiety, and insomnia.ResultsThe prevalence of PSU was 58.5%. Students who relied primarily on online learning had a higher prevalence of depressive symptoms (29.95% vs. 22.24%), anxiety symptoms (25.13% vs. 18.91%), and insomnia symptoms (75.89% vs. 70.27%) than those who relied on traditional face-to-face learning (Ps&lt; 0.05). After adjusting for covariates, subjects with PSU were more likely to report depressive symptoms (AdjOR = 3.14, 95% CI = 2.26–4.37), anxiety symptoms (AdjOR = 3.73, 95% CI = 2.13–4.59), and insomnia symptoms (AdjOR = 2.96, 95% CI = 2.23–3.92) than those without PSU. Furthermore, the associations of PSU with depressive symptoms (OR = 4.66 vs. 2.33,Pfor interaction = 0.015) and anxiety symptoms (OR = 6.05 vs. 2.94,Pfor interaction = 0.021) were more pronounced in the online learning group.ConclusionOur study provides preliminary evidence that Chinese university students have serious smartphone addiction problems, which are associated with depressive, anxiety, and insomnia symptoms. Online learning is found to exacerbate PSU and mental health problems. Our findings provide valuable information for targeted psychological interventions in the post-COVID-19 era.
Clinicopathological Characteristics of Primary Appendiceal Mucinous Neoplasm and Recurrence After Radical Resection
Authors: Wang Zaibiao , Yin Manman , Shao Jiayun , Yin Zhipeng , Peng Jie , Lu Zhengmao 
Published: May 2022

ObjectiveAppendiceal mucinous neoplasm (AMN) is a rare obstructive dilatation of the appendix caused by an intraluminal accumulation of mucoid material, showing an insidious onset and few specific clinical manifestations. The purpose of the study is to analyze clinicopathological characteristics of primary AMN and recurrence after radical resection.MethodsA total of 50 patients were included in the retrospective cohort study of AMN. Patient data, such as demographics, tumor characteristics, surgical management, preoperative serum carcinoembryonic antigen (CEA), and carcinoembryonic antigen 19-9 (CA19-9) levels, were collected. All patients were followed-up with interval CT scans until the end of December 2021, with overall survival (OS) and progression-free survival (PFS) being calculated.ResultsAll patients were confirmed as AMN by pathological diagnosis after surgery, including 28 cases (56.00%) of low-grade AMN (LAMN) and 22 cases (44.00%) of non-LAMN. Among 50 patients with AMN, there were 12 cases (24.00%) complicated with pseudomyxoma peritonei (PMP). Higher proportions of patients with pTis, pT3, pT4a, ruptured at presentation, and PMP were found in patients with non-LAMN patients than LAMN (p &lt; 0.05). There was a remarkable difference about preoperative serum CA19-9 levels between patients with LAMN and non-LAMN (p = 0.044). Patients complicated with PMP had a higher proportion of patients with ruptured at presentation than those who were not (p &lt; 0.001). The patients with PMP had increased tumor size compared with those without PMP (p = 0.031). Remarkable differences were observed in terms of preoperative serum CA19-9 (p = 0.009) levels between patients with PMP and without PMP. We performed a multivariate analysis of the presence or absence of PMP and found that ruptured at presentation was found to be a risk factor for PMP in patients with AMN (p = 0.003). The PFS in the patients with PMP and those without was 33.33% (4/12) and 2.63% (1/38), showing a significant difference (P = 0.002).ConclusionThe study demonstrates that ruptured at presentation and PMP may influence the prognosis and survival of patients with AMN.
Fluorescence-Guided Identification of the Thoracic Duct by VATS for Treatment of Postoperative Chylothorax: A Short Case Series
Authors: Londero Francesco , Grossi William , Vecchiato Massimo , Martino Antonio , Ziccarelli Antonio , Petri Roberto , Morelli Angelo 
Published: May 2022

BackgroundChylothorax is a relatively rare complication after surgery of the mediastinum. The occurrence and the results of surgical treatment of this condition are difficult to foresee due to the wide heterogeneity in thoracic duct anatomy.Case summaryWe report two cases of postoperative chylothorax treated with ligation by video-assisted thoracoscopic surgery (VATS). The first patient developed a massive left chylothorax shortly after discharge, following radical excision of a seminoma-involved left para-aortic lymphadenopathy. The second patient developed a high-output right chylothorax following VATS upper bilobectomy. In both cases, a surgical revision by VATS was performed. Inguinal injection of indocyanine green allowed an easy visualization of the lymphatic leakage point. In both cases, oral feeding was rapidly restarted after surgery. No recurrence of chylothorax was observed.ConclusionThe use of indocyanine green may greatly improve the identification of the thoracic duct during surgical ligation by VATS, with a favorable impact on the postoperative course and overall admission costs.
The Effect of Silicon Dioxide Nanoparticles Combined with Entomopathogenic Bacteria or Fungus on the Survival of Colorado Potato Beetle and Cabbage Beetles
Authors: Shatalova Elena I. , Grizanova Ekaterina V. , Dubovskiy Ivan M. 
Published: May 2022

Three types of modified silicon dioxide nanoparticles (SiO2, 10–20 nm) with additives of epoxy, silane and amino groups, used independently and in combination with the entomopathogenic bacteria Bacillus thuringiensis subsp. morrisoni and fungus Metarhizium robertsii were tested against Colorado potato beetle (Leptinotarsa decemlineata) and cabbage beetles (Phyllotreta spp.). All three nanoparticles were found to have an entomocidal effect on Colorado potato beetle larvae and crucifer flea beetles when ingested. Increased susceptibility of insects to B. thuringiensis or M. robertsii blastospores and their metabolites was shown after exposure to the modified silicon dioxide nanoparticles. The potential of modified silicon dioxide nanoparticles to enhance the efficiency of biopesticides based on the bacteria B. thuringiensis and fungi M. robertsii is considered in the paper.
Why Test study protocol: a UK-wide audit using the Primary Care Academic CollaboraTive (PACT) to explore the reasons for primary care testing
Authors: Burrell Alexander , Duncan Polly , Bennett-Britton Ian , Hodgson Sam , Merriel Samuel WD , Waqar Salman , Whiting Penny , Watson Jessica 
Published: May 2022

BackgroundThe number of blood tests done in primary care has been increasing over the past 20 years. Some estimates suggest that up to one-quarter of these tests may not have been needed. This could lead to a cascade effect of further investigations, appointments, or referrals, as well as anxiety for patients, increased workload, and costs to the health service. To better understand the impact and sequelae of blood tests on patients, it is necessary to know why blood tests are requested and what is done with the results.AimTo explore who orders blood tests and why, and how test results are actioned in primary care.Design & settingRetrospective audit of electronic health records in general practices across the UK.MethodThe Primary care Academic CollaboraTive (PACT), a UK-wide network of primary care health professionals, will be utilised to collect data from individual practices. PACT members will be asked to review the electronic health records of 50 patients who had recent blood tests in their practice, and manually extract anonymised data on who requested the test, the indication, the result, and subsequent actions. Data will also be collected from PACT members to assess the feasibility of the collaborative model.ConclusionPACT offers a unique opportunity to extract clinical data which cannot otherwise be obtained. Understanding the indications for tests will help identify priority areas for research to optimise testing and patient safety in primary care.
Les conventus de Lydie (fin IIe-IIIe siècle de notre ère) : Louis Robert, Konrad Kraft et les analyses élémentaires
Authors: Hochard Pierre-Olivier , Blet-Lemarquand Maryse , Baux Dominique 
Published: May 2022

Résumé -Les liaisons de coins de droit entre monnaies provinciales micrasiatiques issues de cités différentes ont conduit les historiens à imaginer l’existence d’ateliers centraux. Dans une étude parue en 1967, L. Robert émettait l’hypothèse que les capitales de conventus
auraient pu remplir cette fonction, et plaçait beaucoup d’espoir dans l’étude de K. Kraft. Malgré la publication de celle-ci en 1972, la question reste toujours débattue. Des analyses élémentaires de monnaies frappées dans les conventus lydiens apportent un éclairage nouveau sans toutefois confirmer l’hypothèse de L. Robert.
Efectos de la auditoria forense en el control de la corrupción en las entidades públicas del Perú
Authors: Ruelas Marco , Flores Ludwing , Sucari Wilson 
Published: May 2022

La auditoría forense es una herramienta especializada que permite detectar y poner en evidencia el fraude y la corrupción en la alta dirección ejecutiva de las entidades públicas conocidos como “crímenes de cuello blanco” con estructuras cada vez más enraizadas y desarrolladas bajo diversas modalidades y con la intención expresa de aprovecharse y hacerle daño al estado. Sin embargo, en los últimos años en el Perú han sido detectados y expuestos de manera creciente actos de corrupción e inconducta funcional por parte de estos ejecutivos que perjudican de sobremanera al presupuesto asignado para atender las demandas sociales de la población. En esa línea, se llevó a cabo la investigación de nivel explicativa considerando una muestra de 323 individuos (funcionarios públicos activos) elegidos de modo no probabilístico y no aleatorio con una población desconocida. Mediante la encuesta y revisión documental se muestra información relacionado al conocimiento e importancia de la auditoria forense, el gasto publico ejecutado en los años 2019 y 2020 y el perjuicio económico detectado por casos de corrupción e inconducta funcional en las entidades del estado. Entre otros resultados se encontró que el gobierno nacional tiene mayor asignación presupuestal con una ejecución anual del 90.8% en el año 2019 y 89.1% en el año 2020; así mismo, los gobiernos locales ejecutaron el 69.4% y 63.4% en ambos periodos respectivamente y los gobiernos regionales ejecutaron el 85.3% y 89.2% respectivamente; sin embargo, el perjuicio económico por corrupción e inconducta funcional detectado por la Contraloría General de la República, alcanzó su mayor concentración en el sector transportes y comunicaciones con el 25% en al año 2019 y 16.5% en el año 2020, seguido del sector educación con el 15.6% en el año 2019 y 14.5% en el año 2020 y finalmente el sector salud con el 16.2% en el año 2019 y 6.9% en el año 2020.
Conservación de la lengua castellana a través de los ámbitos de la escritura, la investigación y la publicidad. Entrevista al Dr. Ignacio Bosque Muñoz, académico de número de la Real Academia Española
Authors: Delgado Del Águila Jesús Miguel 
Published: May 2022

En esta entrevista se resolvieron las interrogantes formuladas y orientadas a la preservación de la lengua castellana en Hispanoamérica. En principio, se abordaron tres temas fundamentales derivados de esta propuesta: la escritura, la investigación y la publicidad. Con el primer tópico, se discernió la función de las normativas, los diccionarios y los manuales elaborados por la Real Academia Española. Su intervención es enjundiosa, ya que direcciona al lector y académico al perfeccionamiento de su lenguaje, con la finalidad de que no reincida en errores gramaticales. El segundo rubro abarca la investigación. Esta fue destacada porque facilita la interacción de los hablantes de la lengua castellana con las metodologías que se instauran para configurar un lenguaje totémico. Además, se asume que la única manera de difundir y contribuir a ese conocimiento sería por medio de las publicaciones científicas. La tercera variante consiste en cómo se inserta esta inquietud en torno a la lengua castellana en los ámbitos publicitarios. Esto es neurálgico por su audiencia limitada y el desinterés de respaldo por los Gobiernos. Frente a ello, consideré que el Dr. Ignacio Bosque Muñoz era la persona idónea para confrontar esta realidad sobre el castellano. Su rol importante en la RAE y la Asociación de Academias de la Lengua Española (ASALE) lo amerita, así como sus publicaciones orientadas al estudio del idioma con enfoques gramaticales. Con su interacción, la volición de este trabajo se evidenciará con la explicación del panorama vigente de la lengua y su preservación, como cuando uno desea comprender el Quijote, entender las contribuciones gramaticales y lexicales de la RAE y la ASALE o cuestionar la proliferación del idioma desde los medios de comunicación. La auscultación de esas oscilaciones será el aporte de esta entrevista.
FAKTOR FAKTOR YANG BERHUBUNGAN DENGAN PENGGUNAAN KONTRASEPSI PADA MASA PANDEMI COVID 19 DI PUSKESMAS 2 DENSEL
Authors: Agustini Ni Komang Tri , Sagitarini Putu Noviana , Kumala Dewi I Gusti Agung 
Published: May 2022

COVID-19 masih menjadi masalah kesehatan yang dihadapi saat ini. Hal ini berdampak pada pelayanan di semua akses pelayanan termasuk Keluarga Berencana. Program KB mengalami penurunan selama pandemic, hal ini disebabkan karena keterbatasan akses pelayanan akibat pembatasan gerak. Tujuan penelitian ini untuk mengidentifikasi faktor-faktor yang berhubungan dengan penggunaan KB selama masa pandemic COVID-19. Penelitian ini menggunakan metode analitik cross sectional dengan sampel adalah ibu di wilayah kerja Puskesmas II Denpasar Selatan. Teknik sampling adalah concecutive sampling. Analisis yang digunakan adalah analisis univariat dan analisis bivariat menggunakan uji chi square. Hasil penelitian ini menunjukkan sebesar 58,7% ibu menggunakan KB saat pandemic COVID 19. Terdapat hubungan yang bermakna dengan penggunaan KB yaitu keterpaparan informasi (p value < 0,001) dan dukungan suami (p value < 0,001). Faktor usia, tingkat pendidikan dan jumlah anak tidak memiliki hubungan bermakna dengan penggunaan KB. Komitmen suami untuk mendukung istri sangat penting. Perlu peningkatan akses pelayanan KB, peningkatan ketersediaan, keterjangkauan dan kualitas pelayanan KB termasuk pelayanan KIE dan Konseling.
Kata kunci: Faktor-faktor, penggunaan KB, Pandemi COVID-19
AKTIVITAS FISIK LANSIA DI WILAYAH KERJA PUSKESMAS I DENPASAR BARAT PADA MASA PANDEMI COVID-19
Authors: Kresniari Ni Komang , Nuryanto Kadek , Megayanti Sri Dewi 
Published: May 2022

Pada masa pandemi Covid-19 saat ini, kelompok lanjut usia merupakan kelompok yang paling berisiko mengalami morbiditas dan mortalitas. Hal yang dapat dilakukan untuk menjaga dan meningkatkan sistem kekebalan tubuh di masa pandemi adalah dengan melakukan aktivitas fisik. Tujuan : penelitian ini bertujuan untuk mengetahui gambaran aktivitas fisik lansia di Wilayah Kerja Puskesmas I Denpasar Barat pada masa pandemi Covid-19.
Metode penelitian ini menggunakan deskriptif kuantitatif dengan pendekatan cross-sectional menggunakan kuesioner. Sampel yang digunakan berjumlah 109 responden yang dipilih dengan menggunakan teknik simple random sampling.
Hasil Dari 109 responden, mayoritas berusia 60 tahun (12,8%), sebagian besar tidak bekerja sebanyak 47,7%, berjenis kelamin perempuan sebanyak 52,3% dan menikah sebanyak 78,9%. Hasil penelitian ini menunjukkan bahwa sebagian besar aktivitas fisik lansia di Wilayah Kerja Puskesmas I Denpasar Barat pada Masa Pandemi Covid-19 berada pada kategori cukup yaitu sebanyak 53,2%. Aktivitas fisik ringan lansia berada pada kategori baik sebanyak 82,5%, aktivitas fisik sedang berada pada kategori cukup sebanyak 50,4% dan aktivitas fisik berat berada pada kategori rendah sebanyak 35,3%.
Kesimpulan Lansia dapat meningkatkan aktivitas fisiknya dengan mempertahankan kegiatan senam lansia di Puskesmas I Denpasar Barat. Kegiatan senam lansia dapat tetap dijalankan dengan mematuhi protokol kesehatan serta membagi waktu dan jumlah kedatangan lansia yang datang untuk mengikuti senam.
Kata Kunci: Aktivitas Fisik, Lansia, Covid-19