bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gambaran Peresepan Metformin pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Nasional Diponegoro Semarang
Authors: Cahyaningsih Octavia Indah , Dini Intan Rahmania Eka , Hardian Hardian 
Published: September 2022

Diabetes melitus (DM) merupakan sekumpulan gangguan metabolisme yang ditandai oleh kondisi hiperglikemia yang berhubungan dengan abnormalitas metabolisme karbohidrat, lemak, dan protein. DM disebabkan oleh gangguan sekresi insulin, sensitivitas reseptor insulin, atau keduanya. Dalam pengobatan diabetes melitus tipe 2 telah disusun dalam pedoman pengobatan secara internasional seperti American Diabetes Association (ADA) sebagai petunjuk dan rekomendasi dalam pemilihan terapi kepada pasien. Ada berbagai golongan obat yang digunakan dalam pengobatan diabetes melitus tipe 2, salah satunya adalah Metformin.Mengetahui profil pasien yang mendapat terapi metformin dan mengetahui gambaran peresepan metformin pada pasien diabetes melitus tipe 2 sesuai pedoman pengobatan diabetes melitus tipe 2 pada ADA. Penelitian ini merupakan penelitian deskriptif kategorik. Data penelitian berupa rekam medik pasien diabetes melitus tipe 2 yang mendapat terapi metformin di Rumah Sakit Nasional Diponegoro Semarang pada bulan Januari-. Pada penelitian ini indikasi pemberian metformin mengikuti pedoman tata laksana pengobatan diabetes melitus yang diterbitkan oleh ADA. Penelitian didapatkan pada 97 jumlah subjek pasien DM Tipe 2 yang mendapatkan terapi metformin tunggal dan kombinasi tahun 2019 di Rumah Sakit Nasional Diponegoro Semarang, lebih banyak ditemukan jenis kelamin perempuan dengan usia 56-65 tahun, pasien juga memiliki diagnosis DM Tipe 2 dengan komplikasi. Ketepatan peresepan berdasarkan penelitian didapatkan tepat indikasi berdasarkan BMI pasien bebesar 76,3%, berdasarkan diagnosa dokter sebesar 100%. Tepat obat berdasarkan dosis pemberian sebesar 100%. Tepat kondisi pasien sebesar 97,94%. Evaluasi secara keseluruhan peresepan metformin telah mencapai angka 75,26%.Kata Kunci : Diabetes melitus; Metformin; American Diabetes Association
Improving clinical performance of urine sediment analysis by implementation of intelligent verification criteria
Authors: Oyaert Matthijs , Maghari Sena , Speeckaert Marijn , Delanghe Joris 
Published: September 2022

Abstract

Objectives
Urinary test strip and sediment analysis integrated with intelligent verification criteria can help to select samples that need manual review. This study aimed to evaluate the improvement in the diagnostic performance of combined urinary test strip and urinary sediment analysis using intelligent verification criteria on the latest generation automated test strip and urinary fluoresce flow cytometry (UFFC) analysers.

Methods
Urine test strip and sediment analysis were performed using the Sysmex UC-3500 and UF-5000 (Kobe, Japan) on 828 urinary samples at the clinical laboratory of the Ghent University Hospital. The results were compared to manual microscopy using phase-contrast microscopy as a reference. After the application of the intelligent verification criteria, we determined whether the diagnostic performance of urine sediment analysis could be improved.

Results
Application of intelligent verification criteria resulted in an increase in specificity from 88.5 to 96.8% and from 88.2 to 94.9% for red blood cells and white blood cells, respectively. Implementing review rules for renal tubular epithelial cells and pathological casts increased the specificity from 66.7 to 74.2% and from 96.2 to 100.0%, respectively; and improved the diagnostic performance of urinary crystals and atypical cells.

Conclusions
The implementation of review rules improved the diagnostic performance of UFFC, thereby increasing the reliability and quality of urine sediment results.
Quantitative protein mass-spectrometry requires a standardized pre-analytical phase
Authors: Smit Nico P.M. , Romijn Fred P.H.T.M. , van Ham Vanessa J.J. , Reijnders Esther , Cobbaert Christa M. , Ruhaak L. Renee 
Published: September 2022

Abstract

Objectives
Quantitative protein mass-spectrometry (QPMS) in blood depends on tryptic digestion of proteins and subsequent measurement of representing peptides. Whether serum and plasma can be used interchangeably and whether in-vitro anticoagulants affect the recovery is unknown. In our laboratory serum samples are the preferred matrix for QPMS measurement of multiple apolipoproteins. In this study, we investigated the effect of different matrices on apolipoprotein quantification by mass spectrometry.

Methods
Blood samples were collected from 44 healthy donors in Beckton Dickinson blood tubes simultaneously for serum (with/without gel) and plasma (heparin, citrate or EDTA). Nine apolipoproteins were quantified according to standard operating procedure using value-assigned native serum calibrators for quantitation. Tryptic digestion kinetics were investigated in the different matrices by following formation of peptides for each apolipoprotein in time, up to 22 h.

Results
In citrate plasma recovery of apolipoproteins showed an overall reduction with a bias of −14.6%. For heparin plasma only −0.3% bias was found compared to serum, whereas for EDTA-plasma reduction was more pronounced (−5.3% bias) and variable with >14% reduction for peptides of apoA-I, A-II and C-III. Digestion kinetics revealed that especially slow forming peptides showed reduced formation in EDTA-plasma.

Conclusions
Plasma anticoagulants affect QPMS test results. Heparin plasma showed comparable results to serum. Reduced concentrations in citrate plasma can be explained by dilution, whereas reduced recovery in EDTA-plasma is dependent on altered proteolytic digestion efficiency. The results highlight the importance of a standardized pre-analytical phase for accurate QPMS applications in clinical chemistry.
Embedding green synthesized zinc oxide nanoparticles in cotton fabrics and assessment of their antibacterial wound healing and cytotoxic properties: An eco-friendly approach
Authors: Kabeerdass Nivedhitha , Thangasamy Selvankumar , Murugesan Karthikeyan , Arumugam Natarajan , Almansour Abdulrahman I. , Suresh Kumar Raju , Velmurugan Plalanivel , Vijayanand Selvaraj , Nooruddin Thajuddin , Mohanavel Vinayagam , Sivakumar Subpiramaniyam , Mathanmohun Maghimaa 
Published: September 2022

Abstract
This study explores the potential of the natural and cost-effective method of wound healing using Alternanthera sessilis by an in vitro study (using fibroblast L929 cells). Gram-positive bacteria Staphylococcus aureus shows a zone of inhibition of 20 mm at 60 µg concentration in the antibiogram profile against the zinc oxide nanoparticles (ZnONPs) wetted in fabrics synthesized from the Amaranthaceae family. Through characterization studies of the AS-ZnONPs, it was found that UV–visible spectra show a peak in the range of 350–460 nm, Fourier transform infrared spectroscopy spectra show a correlation peak in the range of 340–4,500 cm−1, scanning electron microscope with electron diffraction analysis results in a peak in the range of 7.8–9.4, and high-resolution transmission electron microscope, which exposes the morphological character (diamond shape in a black and white background), shows a peak at 200 nm. This work shows that the leaf extract of A. sessilis might support the ancient method of wound healing.
Desire, Consent and Misogyny in Post-medieval Adaptations of the Pelleas and Ettarde Story
Authors: Piercy Hannah 
Published: September 2022

Abstract
Pelleas and Ettarde may not be particularly well-known figures today, but in the nineteenth and twentieth centuries, following the publication of Alfred Lord Tennyson’s ‘Pelleas and Ettarre’ idyll, they were included or even centred in a number of Arthurian poems, plays and novels. This article explores the changing representations of Pelleas and Ettarde in post-medieval adaptations. Why do writers choose to retell and adapt this story? What kinds of intertextual connections are uncovered by focusing on these particular Arthurian afterlives? And how do modern writers reshape this story in response to contemporary perspectives on desire, consent and misogyny? Drawing upon examples from fourteen canonical and lesser-known works, this essay charts the post-medieval popularity of this story, which offers a valuable case study for understanding the changing representation of desire, consent and misogyny in modern Arthuriana.
The crystal structure of 3-((4-chloro-N-(2-methoxyethyl)benzamido)methyl)phenyl methanesulfonate, C18H20ClNO5S
Authors: Li Yong , Wu Yundeng , Wang Jingjing 
Published: September 2022

Abstract
C18H20ClNO5S, monoclinic, P21/n (no. 14), a = 5.671(4) Å, b = 18.225(13) Å, c = 17.99(2) Å, β = 90.18(4)°, V = 1859(3) Å3, Z = 4, R

gt
(F) = 0.0316, wR

ref
(F
2) = 0.0813, T = 170 K.
Experimental cross section of the 164Dy(n,γ)165Dy reaction at the neutron energy of 0.0372 eV using Neutron Diffraction Facility
Authors: Belouadah Naima , Kadem Fatiha , Slamene Hocine , Osmani Nadjet , Belgaid Mohamed , Yettou Leila , Trari Mohamed 
Published: September 2022

Abstract
The neutron capture cross section for the 164Dy(n,γ)165Dy reaction at 0.0372 eV energy was measured using the horizontal channel (Neutron Diffraction Facility) of Es-Salam nuclear research reactor in Birine-Algeria. The Neutron Activation Analysis (NAA) technique using 197Au(n,γ)198Au as reference reaction was adopted. The γ ray spectra for the Dy2O3 target powder and two thin gold foil were detected for the Germanium Hyper Pure coupled in the Genie 2000 data acquisition software. A resulting σ-value (2198.5 ± 94) b was measured for the thermal neutron cross section after correcting the thermal neutron self-shielding and γ attenuation effects. The measured value was then compared to the evaluated cross sections reported in two different libraries of neutron databases ENDF/B-VIII.0 and JEFF-3.3. The measured data at 0.0372 eV has been extrapolated to the energy of 0.0253 eV assuming 1/ν dependence in the thermal energy region and the result was compared with the fully measured values reported in the literature.
Kirchengeschichtsdidaktik ‚up to date‘. Grundlegungen und Perspektiven am Beispiel von MrWissen2go
Authors: Käbisch David , Lindner Konstantin 
Published: September 2022

Zusammenfassung
Es gibt immer mehr Literatur, in der die Bedeutung des digitalen Geschichtenerzählens in der Lebenswelt von Schüler:innen untersucht wird. Ausgehend von ambivalenten Narrativen in religionsbezogenen Erklärfilmen von MrWissen2go alias Mirko Drotschmann fragt vorliegender Beitrag nach Perspektiven einer aktuellen Didaktik der Kirchengeschichte: erstens bezüglich Kirchengeschichte als Zugang zur religiösen Deutung der Wirklichkeit in säkularer Zeit, zweitens hinsichtlich postkolonial revidierter Ansätze und drittens in Bezug auf die Herausforderungen der Digitalisierung. Insgesamt leistet dieser Aufsatz einen innovativen Beitrag zu neueren historiographischen und didaktischen Debatten über Religion und Bildung heute.
Barokk udvariság, jezsuita hagyomány
Authors: Pálfy Eszter 
Published: September 2022

Gyöngyösi István 1664-ben keletkezett munkáját, a Márssal társolkodó Murányi Vénust az utóbbi évtized kutatástörténete a barokk udvariság morálfilozófiai hagyományába illeszti. A dolgozat ezen az eszmetörténeti kontextuson belül tárgyalja a Murányi Vénust, kiegészítve a vizsgálódást a Gyöngyösi-kutatás friss, 2017-es fejleményével. Tusor Péter tanulmánya szerint a költő Gyöngyösi István korábban ismert életrajzi adatainak jelentős része téves, mert egy másik Gyöngyösi Istvánra vonatkozik. Az új történeti kutatások rávilágítottak, hogy Gyöngyösi nem protestáns, hanem katolikus neveltetésben részesült, s a nagyszombati jezsuita egyetemre járt; ily módon a Murányi Vénus barokk jezsuita hagyomány felől való vizsgálata életrajzilag is megalapozottá válik. Ha a Murányi Vénust egybevetjük a jezsuita főúr, Csáky István Politica philosophiai Okoskodása című udvari maximagyűjteményével, megállapíthatjuk, hogy a Gyöngyösi-mű egyes jellemzői nagy valószínűséggel a jezsuita oktatásban gyökereznek.
Egy tanulmányút költői átváltozása
Authors: Takáts József 
Published: September 2022

Eötvös József Búcsú című költeményét mindeddig általában életrajzi keretben értelmezték: a szerző 1836 nyarán nyugat-európai tanulmányútra indult, ezért vett búcsút a hazájától. E kis tanulmány felveti, hogy a költeményben fellelhető ellentmondások és hiányok talán a cenzúra kijátszásának szándékával magyarázhatók. Összefüggésbe hozza a Búcsú nyelvezetét az ellenzéki sérelmi politika szókincsével, és lehetségesnek tartja, hogy éppúgy a magyar politika 1835-1836-os válságára adott válasz, mint Vörösmarty Mihály Szózata. A republikánus hagyomány felől nézve a költeményt beszélőjének búcsúvételét az önkéntes száműzetés sejtetésének tekinti, az Ubi libertas, ibi patria (Ahol a szabadság, ott a haza) latin szállóigére írott variációnak.
The Influence of Specimen Preparation on the Results of the Ball-on-Three-Ball (B3B) Test for Cementitious Materials
Authors: Thiha Zaw Myo , Burkan Isgor O. , Jason Weiss W. 
Published: September 2022

AbstractThe ball-on-three-ball test method (B3B) is used to measure the flexural strength of cement paste and mortar. This method has the advantage of utilizing small and thin samples requiring less material and improved sensitivity, allowing a large number of samples to be tested for improved variability assessment, and assessing chemical degradation rapidly because of its relatively high surface-to-volume ratio. This paper examines two specific questions that have surfaced with the recent adoption of this test method in ASTM C1904-20, Standard Test Methods for Determination of the Effects of Biogenic Acidification on Concrete Antimicrobial Additives and/or Concrete Products. The first question is whether the mixing technique used in sample preparation impacts the results. It was found that the use of vacuum mixing (ASTM C1904-20) and Hobart mixing (ASTM C227-10, Standard Test Method for Potential Alkali Reactivity of Cement-Aggregate Combinations (Mortar-Bar Method), and ASTM C305-20, Standard Practice for Mechanical Mixing of Hydraulic Cement Pastes and Mortars of Plastic Consistency), provide comparable results; however, the high-shear mixing (ASTM C1738, Standard Practice for High-Shear Mixing of Hydraulic Cement Paste) indicated that the results were not statistically similar to the other mixing techniques. The second question is related to the timing of the test after the samples are removed from an exposure solution. It was found that the sample should be removed from the exposure solutions and tested within 10 minutes to maintain low variability. These results will provide information needed to evaluate changes for ASTM C1904-20.
Application of Stiffness Damage Test on Rubberized Concrete
Authors: Diab S. H. , Soliman A. M. , Alotaibi K. S. , Nokken M. R. 
Published: September 2022

Abstract
Utilizing waste rubber tires in concrete as a partial replacement of aggregate reduces its carbon footprint and modifies its performance. Several researchers have evaluated the properties of crumb rubber concrete (CRC). This article evaluated the potential of one of the most promising testing techniques for concrete (i.e., the stiffness damage test (SDT)) for CRC. Fine crumb rubber aggregate (FCRA) was added as a replacement for fine aggregate at a dosage of 10 % by volume. Results reveal that compressive strength decreased by 29.5 %, 28.4 %, and 28.0 %, and tensile strength decreased by 31.1 %, 31.3 %, and 28.0 % because of FCRA at 28, 56, and 90 days, respectively. A strong relation was found between the strength and time (i.e., specimen age) and was represented linearly with R2 around 0.99 for compressive and tensile strength. The modulus of elasticity of CRC showed 27.7 %, 26.0 %, and 25.5 % reductions at 28, 56, and 90 days, respectively. Poisson’s ratio for the same mixture exhibited an increase of about 34.7 %, 31.3 %, and 28.0 % at 28, 56, and 90 days, respectively. The results showed that SDT output parameters, including the hysteresis area, stiffness, plasticity deformation, and elasticity, decreased as a function of time and were sensitive enough to quantify the change of CRC mixture properties. In addition, adding FCRA caused an increase in plasticity deformation and elasticity over time.
Simulated Strains-Based Approach for Explaining Distortion and Residual Stress in Quenched Pure Iron Cylinder
Authors: Arimoto Kyozo 
Published: September 2022

AbstractDistortion and residual stress in steel parts because of heat treatment affect assembled products’ performance and life. A trial-and-error method has been used traditionally to solve problems, which requires a lot of time and cost. In the 1970s, heat treatment simulation was realized based on theoretical studies for predicting temperature, volume fraction of metallic phase, stress, strains, and so on, during the processes. In the early 2000s, an approach was established to explain the origin of distortion and residual stress based on the simulated results, especially various kinds of strains, which is called the simulated strains-based approach by the author. This approach has been made possible by simulation, which has provided results such as the time history of strain distribution. The subject of the residual stress generation mechanism in a quenched pure iron cylinder is taken here to illustrate the advantages of this approach. The classic study of this problem is Rose's illustration using a conceptual diagram of the variation of temperature and stress at the surface and center of the cylinder. In connection with this diagram, thermal shrinkage and elastic deformation, and the relationship between them and stress, are qualitatively explained. However, it is difficult to understand this diagram logically because the meaning of the correction applied to the stresses after the onset of plasticity was not clearly explained. On the other hand, the simulated strains-based approach using changes in distributions of thermal, elastic, plastic, and total strains provided a clear explanation of how the final distribution of the elastic strain, which is corresponded to the residual stress, is generated. Because quenching of steel parts produces additional transformation strain and transformation plastic strain, the quenching of pure iron is an excellent introduction to the application of a simulated strains-based approach.
A serious and unusual presentation of congenital isolated ACTH deficiency due to TBX19 mutation, beyond the neonatal period
Authors: Vieira Inês Henriques , Mourinho Bala Nádia , Ramos Fabiana , Dinis Isabel , Cardoso Rita , Caetano Joana Serra , Rodrigues Dírcea , Paiva Isabel , Mirante Alice 
Published: September 2022

Summary
Congenital isolated adrenocorticotrophic hormone (ACTH) deficiency due to T-box transcription factor-19 (TBX19 mutation) (MIM 201400; ORPHA 199296) usually presents in the neonatal period with severe hypoglycemia, seizures, and sometimes prolonged cholestatic jaundice. We report a case with an unusual presentation that delayed the diagnosis. A 9-month-old female patient with no relevant personal history was admitted to the emergency department due to a hypoglycemic seizure in the context of acute gastroenteritis. There was rapid recovery after glucose administration. At age 4, she presented with tonic-clonic seizures, fever, and gastrointestinal symptoms and came to need support in an intensive care unit. Low serum cortisol was documented and hydrocortisone was initiated. After normalization of inflammatory parameters, the patient was discharged with hydrocortisone. The genetic investigation was requested and compound heterozygous mutations in TBX19 were detected. This is a rare case of presentation of TBX19 mutation outside the neonatal period and in the setting of acute disease, which presented a diagnostic challenge.

Learning points

Congenital isolated adrenocorticotrophic hormone deficiency due to TBX19 mutation usually presents with neonatal hypoglycemia and prolonged cholestatic jaundice.

An uneventful neonatal period, however, does not exclude the diagnosis as the disease may be asymptomatic at this stage.

In the context of idiopathic hypoglycemia, even in the context of acute disease, hypocortisolism must always be excluded.

Genetic evaluation should be performed in cases of congenital central hypocortisolism to allow proper counselling.
Balancing Protection and Progress in Pediatric Palliative Care Research: Stakeholder Perspectives
Authors: Mooney-Doyle Kim , Pyke-Grimm Kimberly A. , Lanzel Ashley Foster , Montgomery Kathleen E. , Hassan Jamila , Thompson Anisha , Rouselle Rebecca , Matheny Antommaria Armand H. 
Published: September 2022

Pediatric palliative care, including end-of-life care, remains a relatively new area of interdisciplinary clinical practice and research. Improving the multifaceted and complex care of children and their families involves research that (1) documents the experiences of children with serious illness, their families, and clinicians; (2) evaluates relationships between contextual factors and health outcomes; and (3) establishes a stronger foundation for child- and family-focused interventions to improve care.
Partnership among stakeholders in family-focused research begins from design through conduct of the study. This partnership is the foundation of a dynamic research process that illuminates critical perspectives. We present a hypothetical pediatric palliative study; a qualitative descriptive study of the perspectives of adolescents and young adults with life-limiting illnesses and their parents after a discussion about an end-of-life decision. Pediatric palliative care researchers, institutional review board leaders, and the parent of a child who died comment on how to balance the obligations to improve clinical care and to protect participants in research. Their recommendations include recruiting a wide range of participants, differentiating emotional responses from harm, approaching potential participants as individuals, and seeking feedback from family advisory boards and designated reviewers with content expertise.
Estructura Interna del Inventario Peruano de Mindfulness y Ecuanimidad
Authors: Moscoso Manolete S. , Merino-Soto Cesar 
Published: September 2022

El propósito del presente estudio es examinar la validez de constructo y consistencia interna del Inventario Peruano de Mindfulness y Ecuanimidad. Basado en el análisis factorial y la Teoría de Respuesta al Item (Modelo de Crédito Parcial y el Método de Escalabilidad de Mokken), se examinó la magnitud de los parámetros y se estimó la varianza de cada uno de los ítems para contribuir en el constructo general de mindfulness. La muestra del estudio está compuesta por 602 adultos, estudiantes de tres instituciones académicas de educación superior de Lima, Chiclayo y Chimbote en el Perú. Los resultados de estos análisis indican una estructura unidimensional del instrumento, en función a ocho ítems representados por los atributos de atención, consciencia, aceptación, juicio de valor, y ecuanimidad. Los indicadores de ajuste del modelo de factores oblicuos para los ítems seleccionados fueron satisfactorios: CFI = .982, RMSEA = .043 (IC90% = .029, .056), SRMR = .048, SB-c2 (gl: 35) = 73.415 (p > 0.05).

Cómo citar este artículo: Moscoso, M. S., & Merino-Soto, C. M. (2020). Estructura Interna del Inventario Peruano de Mindfulness y Ecuanimidad. Revista Colombiana de Psicología, 31(1), 49-64. https://doi.org/10.15446/rcp.v31n1.96718