bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Analysis of SARS-CoV-2 Vaccine Reactogenicity: Variation by Type, Dose, and History, Severity, and Recency of Prior SARS-CoV-2 Infection
Authors: Scher Ann I , Berjohn Catherine M , Byrne Celia , Colombo Rhonda E , Colombo Christopher J , Edwards Margaret Sanchez , Ewers Evan C , Ganesan Anuradha , Jones Milissa , Larson Derek T , Libraty Daniel , Lindholm David A , Madar Cristian S , Maldonado Carlos J , Maves Ryan C , Mende Katrin , Richard Stephanie A , Rozman Julia S , Rusiecki Jennifer , Smith Alfred , Simons Mark , Tribble David , Agan Brian , Burgess Timothy H , Pollett Simon D ,   EPICC COVID-19 Cohort Study Group, Merritt S , Merritt T , Lewis McChord Joint Base , Chambers S , Faestel COL P , Mount COL C , Stein M , Uyehara C , Broder C , Chung COL (Ret.) K , Epsi N , Hickey COL P , Livezey LTC J , Parmelee E , Samuels E , Wayman M , Chao TSgt T , Lanter K , Meyer J , Reynolds K , Starr C , Iskander CAPT J , Kamara CDR I , Hostler LTC D , Huprikar MAJ N 
Published: June 2022

Abstract

Background
There is limited information on the functional consequences of coronavirus disease 2019 (COVID-19) vaccine side effects. To support patient counseling and public health messaging, we describe the risk and correlates of COVID-19 vaccine side effects sufficient to prevent work or usual activities and/or lead to medical care (“severe” side effects).

Methods
The EPICC study is a longitudinal cohort study of Military Healthcare System beneficiaries including active duty service members, dependents, and retirees. We studied 2789 adults who were vaccinated between December 2020 and December 2021.

Results
Severe side effects were most common with the Ad26.COV2.S (Janssen/Johnson and Johnson) vaccine, followed by mRNA-1273 (Moderna) then BNT162b2 (Pfizer/BioNTech). Severe side effects were more common after the second than first dose (11% vs 4%; P &lt; .001). First (but not second) dose side effects were more common in those with vs without prior severe acute respiratory syndrome coronavirus 2 infection (9% vs 2%; adjusted odds ratio [aOR], 5.84; 95% CI, 3.8–9.1), particularly if the prior illness was severe or critical (13% vs 2%; aOR, 10.57; 95% CI, 5.5–20.1) or resulted in inpatient care (17% vs 2%; aOR, 19.3; 95% CI, 5.1–72.5). Side effects were more common in women than men but not otherwise related to demographic factors.

Conclusions
Vaccine side effects sufficient to prevent usual activities were more common after the second than first dose and varied by vaccine type. First dose side effects were more likely in those with a history of COVID-19—particularly if that prior illness was severe or associated with inpatient care. These findings may assist clinicians and patients by providing a real-world evaluation of the likelihood of experiencing impactful postvaccine symptoms.
Abscisic acid influences ammonium transport via regulation of kinase CIPK23 and ammonium transporters
Authors: Ganz Pascal , Porras-Murillo Romano , Ijato Toyosi , Menz Jochen , Straub Tatsiana , Stührwohldt Nils , Moradtalab Narges , Ludewig Uwe , Neuhäuser Benjamin 
Published: June 2022

Abstract
Ammonium uptake at plant roots is regulated at the transcriptional, posttranscriptional, and posttranslational levels. Phosphorylation by the protein kinase calcineurin B-like protein (CBL)-interacting protein kinase 23 (CIPK23) transiently inactivates ammonium transporters (AMT1s), but the phosphatases activating AMT1s remain unknown. Here, we identified the PP2C phosphatase abscisic acid (ABA) insensitive 1 (ABI1) as an activator of AMT1s in Arabidopsis (Arabidopsis thaliana). We showed that high external ammonium concentrations elevate the level of the stress phytohormone ABA, possibly by de-glycosylation. Active ABA was sensed by ABI1-PYR1-like () complexes followed by the inactivation of ABI1, in turn activating CIPK23. Under favorable growth conditions, ABI1 reduced AMT1;1 and AMT1;2 phosphorylation, both by binding and inactivating CIPK23. ABI1 further directly interacted with AMT1;1 and AMT1;2, which would be a prerequisite for dephosphorylation of the transporter by ABI1. Thus, ABI1 is a positive regulator of ammonium uptake, coupling nutrient acquisition to abiotic stress signaling. Elevated ABA reduces ammonium uptake during stress situations, such as ammonium toxicity, whereas ABI1 reactivates AMT1s under favorable growth conditions.
Rescaling Resettlement: Local Welcoming Policies and the Shaping of Refugee Belonging
Authors: Watson Jake 
Published: June 2022

Abstract
This paper brings together scholarship on race, place, and legal status to examine how local context mediates the outcomes of federal refugee resettlement policy. Over the past several decades, local actors across the United States have developed initiatives to “welcome refugees” that interact with and extend beyond the formal federal program to shape refugee incorporation. Drawing on a comparative study of Pittsburgh, Pennsylvania, and Atlanta, Georgia, I show that these initiatives construct different aspects of refugee identity as socially valuable. Refugees learn about these valuations as they seek access to resources and recognition, in turn amplifying desirable aspects of their identity to claim belonging and to distance themselves from racialized and stigmatized others. In Pittsburgh, refugees emphasize their ethnic identity and membership to ethnic groups, while refugees in Atlanta claim belonging by emphasizing their legal and humanitarian status as refugees. This paper contributes to scholarly understandings of refugee resettlement as a racialized process mediated by the institutional and socio-cultural dynamics of local context. Moreover, this paper extends calls to rethink the immigrant/refugee distinction by revealing the variable salience of the refugee status across subnational space.
Diagnosing and treating Mycobacterium kansasii
Authors: Moore Randy R. , Holder Douglas , Earnest Sarah 
Published: June 2022

ABSTRACT
This article describes an 18-year-old immunocompetent patient who developed Mycobacterium kansasii, manifested with shortness of breath and a cavitary lung lesion seen on radiograph. Initial sputum smears were negative; however, after 2 weeks, the cultures grew M. kansasii and the patient was started on an antimycobacterial regimen.
Nonsteroidal anti-inflammatory drugs and cardiovascular disease risk in spondyloarthritis-spectrum diseases
Authors: So Ho , Tam Lai-Shan 
Published: June 2022

Purpose of review
Increased cardiovascular (CV) risk associated with nonsteroidal anti-inflammatory drugs (NSAIDs) is well recognized in the general population. This may limit the use of this effective therapy in patients with spondyloarthritis (SpA), a population already at high CV risk.

Recent findings
Increased CV diseases and their risk factors in patients with SpA were consistently shown in recent population-level data. NSAIDs remained commonly prescribed in SpA, though their structural benefit remained controversial and the dispensing practice was variable in different regions in the world. A previous observation study suggested NSAIDs in SpA might be cardio-protective, possibly via their modulation of the chronic inflammatory state. A recent meta-analysis of nonrandomized studies also revealed no increased risk of a CV event. Interestingly, there is growing evidence that different NSAIDs might impose differential CV risk on patients with SpA.

Summary
Recent evidence suggested NSAIDs were associated with a neutral and possibly lower CV risk in patients with SpA, which provided some reassurance for their use.
Achilles Tendon-Bone Allograft is Advantageous for Chronic Patellar Tendon Ruptures Using a Modified Fixation Technique
Authors: Keyhani Sohrab , Movahedinia Mohammad , Amouzadeh Farzad , Ghanbari Naser 
Published: June 2022

Objectives:
A patellar tendon rupture is an extremely disabling extensor mechanism injury. This follow-up study describes the clinical and radiologic outcomes of a new modified technique for reconstructing chronic patellar tendon ruptures.

Materials and Methods:
From 2014 to 2018, we reconstructed 15 chronic patellar tendon ruptures using Achilles tendon-bone allograft. Clinical and radiologic outcomes were evaluated preoperatively and during the final follow-up, 2 to 7 years after reconstruction. Assessments involved the International Knee Documentation Committee (IKDC), Lysholm, and Kujala scores, as well as quadriceps muscle strength and extension lag. Radiologic results were evaluated using the Insall-Salvati index on plain radiography and allograft integration through magnetic resonance imaging.

Results:
At the final follow-up, the Lysholm, IKDC, and Kujala scores improved by 57, 58, and 54 points, respectively (P<0.001). The average quadriceps muscle strength improved from 2.6 (2 to 3) before the operation to 4.6 (4 to 5) at the final follow-up (P<0.001). The extension lag also improved significantly from 31.7 degrees (25 to 40) to 0.6 degrees (0 to 10). The preoperative Insall-Salvati index was 1.6 (1.5 to 1.9), which improved significantly to 1.2 (1 to 1.3) postoperatively (P<0.001). Two years after the operation, magnetic resonance imaging showed good allograft integration in all pateints.

Conclusion:
Combining an Achilles tendon-bone allograft with a robust fixation method led to favorable clinical and radiologic outcomes.

Level of Evidence:
Level IV.
How could HIV-1 drug resistance impact preexposure prophylaxis for HIV prevention?
Authors: Parikh Urvi M. , Mellors John W. 
Published: June 2022

Purpose of review
To review current laboratory and clinical data on the frequency and relative risk of drug resistance and range of mutations selected from approved and investigational antiretroviral agents used for preexposure prophylaxis (PrEP) of HIV-1 infection, including tenofovir disproxil fumarate (TDF)-based oral PrEP, dapivirine ring, injectable cabotegravir (CAB), islatravir, lenacapavir and broadly neutralizing antibodies (bNAbs).

Recent findings
The greatest risk of HIV-1 resistance from PrEP with oral TDF/emtricitabine (FTC) or injectable CAB is from starting or continuing PrEP after undiagnosed acute HIV infection. By contrast, the dapivirine intravaginal ring does not appear to select nonnucleoside reverse transcriptase inhibitor resistance in clinical trial settings. Investigational inhibitors including islatravir, lenacapavir, and bNAbs are promising for use as PrEP due to their potential for sustained delivery and low risk of cross-resistance to currently used antiretrovirals, but surveillance for emergence of resistance mutations in more HIV-1 gene regions (gag, env) will be important as the same drugs are being developed for HIV therapy.

Summary
PrEP is highly effective in preventing HIV infection. Although HIV drug resistance from PrEP use could impact future options in individuals who seroconvert on PrEP, the current risk is low and continued monitoring for the emergence of resistance and cross-resistance during product development, clinical studies, and product roll-out is advised to preserve antiretroviral efficacy for both treatment and prevention.
Barriers to up-titrated antihypertensive strategies in 12 sub-Saharan African countries: the Multination Evaluation of hypertension in Sub-Saharan Africa Study
Authors: Cavagna Pauline , Kramoh Kouadio Euloge , Diop Ibrahima Bara , Kouam Kouam Charles , Ikama Meo Stéphane , Takombe Jean Laurent , Damorou Jean Marie , Ali Toure Ibrahim , Balde Dadhi M. , Dzudie Anastase , Khoury Stéphanie , Perier Marie Cécile , Asselin Anouk , Azizi Michel , Houenassi Martin Dèdonougbo , Kane Abdoul , Kimbally-Kaki Suzy Gisèle , Kingue Samuel , Limbole Emmanuel , Mfeukeu Kuate Liliane , Mipinda Jean Bruno , Ferreira Beatriz , Nhavoto Carol , Sidy Ali Abdallahi , Empana Jean Philippe , N’guetta Roland , Jouven Xavier , Antignac Marie 
Published: June 2022

Background:
Sub-Saharan Africa (SSA) faces the highest rate of hypertension worldwide. The high burden of elevated blood pressure (BP) in black people has been emphasized. Guidelines recommend two or more antihypertensive medications to achieve a BP control. We aimed to identify factors associated with prescription of up-titrated antihypertensive strategies in Africa.

Methods:
We conducted a cross-sectional study on outpatient consultations for hypertension across 12 SSA countries. Collected data included socioeconomic status, antihypertensive drugs classes, BP measures, cardiovascular risk factors and complication of hypertension. We used ordinal logistic regression to assess factors associated with prescription of up-titrated strategies.

Results:
The study involved 2123 treated patients with hypertension. Patients received monotherapy in 36.3 vs. 25.9%, two-drug in 42.2 vs. 45% and three and more drugs strategies in 21.5 vs. 29.1% in low (LIC) and middle (MIC) income countries, respectively. Patients with sedentary lifestyle [OR 1.4 (1.11–1.77)], complication of hypertension [OR 2.4 (1.89–3.03)], former hypertension [OR 3.12 (2.3–4.26)], good adherence [OR 1.98 (1.47–2.66)], from MIC [OR 1.38 (1.10–1.74)] and living in urban areas [OR 1.52 (1.16–1.99)] were more likely to be treated with up-titrated strategies. Stratified analysis shows that in LIC, up-titrated strategies were less frequent in rural than in urban patients (P for trend <0.01) whereas such difference was not observed in MIC.

Conclusion:
In this African setting, in addition to expected factors, up-titrated drug strategies were associated with country-level income, patient location and finally, the interplay between both in LIC. These results highlight the importance of developing policies that seek to make multiple drug classes accessible particularly in rural and LIC.
Remote Video Monitoring of Simultaneous Visual Field Testing
Authors: Meshkin Ryan S. , Zhao Yan , Elze Tobias , Boland Michael V. , Friedman David S. 
Published: June 2022

Précis:
In this prospective interventional case series that included 474 patients, there were no significant differences in visual field (VF) parameters between fields from patients tested one-at-a-time and simultaneously, except for fixation losses.

Purpose:
To test for differences in reliability and performance parameters of patients taking VF tests while using a remote patient monitoring system to supervise 1 or 2 test sessions simultaneously.

Methods:
In a prospective interventional case series, 861 eyes of 474 consecutive patients undergoing automated perimetry during a 6-month period were monitored during the test using an audio/video-enabled remote monitoring system. Two patients were simultaneously tested (simultaneous test) by a single technician if they were ready for testing at the same time. Patients were otherwise tested individually (single test). Performance and reliability parameters including false negatives, false positives, fixation losses, mean deviation, pattern standard deviation, VF index, and test duration were compared between patients undergoing simultaneous tests and single tests. Patients undergoing remotely monitored testing, for whom a prior VF could be found, had performance and reliability parameters compared with those prior tests. VFs were analyzed separately for 2 test strategies: SITA Standard 24-2 and SITA Faster 24-2C.

Results:
No significant parameter differences were observed among SITA Standard 24-2 VFs between single and simultaneous tests, except for fixation losses (single: 16.8±19.7%, simultaneous: 22.5±25.0%, P=0.01). Similarly, there were no significant differences observed among SITA Faster 24-2C tests. Paired analyses comparing remotely monitored VFs with prior traditionally monitored VFs showed no significant differences for any parameters, except for fewer fixation losses with remote monitoring (traditional: 23.6±27.5%, remote 17.7±20.8%, P=0.003).

Conclusions:
Remote patient monitoring of VF testing enabled technicians to supervise testing of 2 patients simultaneously with preserved performance and reliability.
The Impact of Childhood and Parental Vaccination on SARS-CoV-2 Infection Rates in Children
Authors: Yigit Metin , Ince Yunus Emre , Kalayci Furkan , Santaflioglu Beytullah , Kurt Funda , Ozkaya-Parlakay Aslinur , Dibek Misirlioglu Emine , Senel Emrah 
Published: June 2022

Background:
The data on the indirect protection of children via the coronavirus disease 2019 (COVID-19) vaccination of household members are insufficient, and analyses to evaluate the efficacy of COVID-19 vaccines are limited.

Methods:
We gathered data on 12,442 patients under the age of 18 regarding the vaccination status of their household members, their vaccine preferences and doses, and their previous history of COVID-19 infection immediately before the patients were administered a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between September 1, 2021 and December 5, 2021.

Results:
A total of 18.4% (2289) were vaccinated, 91.4% with BNT162b2mRNA vaccine, 8.6% with inactivated COVID-19 vaccine; 48.7% received a single dose, and 51.3% had 2 doses. Real-time RT-PCR positivity proportions were much higher in older children (P < 0.001) and were higher in children 12 years of age and older [odds ratio (OR), 1.34; 95% confidence interval (CI): 1.21–1.47] compared with others. SARS-CoV-2 infection was significantly lower in the vaccinated group (fully and incompletely) (P < 0.001). Unvaccinated (OR, 4.88; 95% CI: 3.77–6.13) and incompletely vaccinated children (OR, 1.83; 95% CI: 1.52–2.12) had a higher risk of COVID-19 infection compared with fully vaccinated patients No significant association was found between the COVID-19 real-time RT-PCR positivity rates of patients and the vaccination status or vaccine preferences of household members (P > 0.05 each).

Conclusions:
SARS-CoV-2 infection rates were significantly lower in vaccinated children, especially with mRNA vaccines. The indirect protection of unvaccinated children via the vaccination of household members against COVID-19 seems inadequate. The individual vaccination of children remains crucial.
Management of corneal haze and edema post-PRK
Authors: Awidi Abdelhalim , Ahmed Ishrat , Daoud Yassine J. 
Published: June 2022

Introduction:
To present the potential use of serum tears, corneal crosslinking, and phototherapeutic keratectomy in the management of corneal haze and edema post-photorefractive keratectomy (PRK).

Patient and Clinical Findings:
A patient who underwent PRK and subsequently developed corneal haze and edema was treated using conservative management to achieve moderate improvement.

Diagnosis, Intervention, and Outcomes:
The combination of serum tears, corneal crosslinking, and phototherapeutic keratectomy was used to treat corneal haze and edema, helping the patient achieve an uncorrected visual acuity of 20/20 in the last follow-up.

Conclusions:
The use of serum tears, corneal crosslinking, and phototherapeutic keratectomy may provide an additional therapeutic option in the treatment of corneal haze and edema that develops post-PRK.
Extracellular vesicles in human milk
Authors: Golan-Gerstl Regina , Reif Shimon 
Published: June 2022

Purpose of review
Milk-derived extracellular vesicles (MDEVs) are nanovesicles that carry microRNA (miRNA) DNA, RNA, proteins and lipids. MDEVs have a potential of therapeutic targets, based on their properties and cargo profile. The present review summarizes recent studies on MDEVs, their cargo and potential role in mammalian development.

Recent findings
The detailed characterization of their miRNA cargo leads to the conclusion of their potential importance in the regulation of gene expression, immune function, development and infant growth.
While their miRNAs are important regulatory elements and their profile expression was characterized in various mammalian milk sources, little is known about their effect on infant health and development. MiRNA activity in breast milk is likely influenced by the overall ecosystem of the early environment, including maternal characteristics, behaviors, and health.

Summary
MDEVs may have an important role in early child development and infant future health. Understanding benefits of MDEVs characteristics have potential role on gut maturation, immune system development and the prevention of metabolic disorders.
3D printed foods-carbs from the lab for better health
Authors: Singh Jyoti , Kaur Jaspreet , Rasane Prasad , Kaur Sawinder 
Published: June 2022

Purpose of review
The purpose of the review is to describe carbohydrate based 3D food printing technology in light of how it is affected by the use of various ingredients of ink and the properties associated with carbohydrate inks used for printing. Special focus is diverted to evaluate its effect on texture and corresponding health implications associated with carbohydrate based printed foods.

Recent findings
The focus of 3D food printed products has revolved around texture modulation and carbohydrates are the best possible additives to achieve this modification. Carbohydrate based inks are used to design healthy texturized printed foods to provide various health benefits to consumer in addition to satisfy their aesthetic requirements. Other ingredients such as prebiotics and probiotics are major adjuncts that add value to these carbohydrates based 3D food printed foods and may have synergistic effects.

Summary
Although much of the current attention is on texture modulation, health aspects of the foods naturally drive the future course of research associated with the carbohydrate based 3D food printed foods.
Assessment of the Wisconsin Criteria at a Level I Trauma Center
Authors: Gray Megan C. , Kollu Tejas , Uppal Priya A. , Hanos Christina , Heiman Adee , Ricci Joseph A. , Patel Ashit 
Published: June 2022

Abstract:
The Wisconsin Criteria was developed for physicians evaluating facial trauma to determine the likelihood of facial fractures. Subsequent studies have not consistently validated these criteria. This study seeks to validate the Wisconsin Criteria and determine its utility in predicting operative facial fractures.
Retrospective chart review of the trauma database registry at a Level I Trauma Center was conducted from September 2011 to May 2019. Adult patients who had a complete facial examination by otolaryngology or plastic surgery as well as a head computed tomography scan completed, were included. Fisher exact test was utilized for statistical analysis (P < 0.05) and positive predictive value, and negative predictive value (NPV) were calculated with a 95% confidence interval.
After screening, 546 patients met eligibility, 448 had at least 1 finding of the Wisconsin Criteria, and 472 patients had facial fractures. The sensitivity of the Wisconsin Criteria for determining the presence of a facial fracture was 86.23%, the specificity was 44.59%, and the NPV was 33.67% (P < .0001). Malocclusion was the criterion most specific in determining if a facial fracture was present (98.65%), and Glasgow Coma Score < 14 was the least specific (67.57%).
The Wisconsin Criteria did aid in the identification of facial fractures in trauma patients with a comparable sensitivity, higher specificity, and much lower NPV than originally described. Further investigation should be done to validate the criteria in other large trauma centers.
Extracranial Craniopharyngioma Confined to the Sphenoid Sinus
Authors: Ko Min Chul , Kim Jung Soo , Kim Mee-Seon , Heo Sung Jae 
Published: June 2022

Abstract:
Craniopharyngioma is rare epithelial tumor that develops along the craniopharyngeal duct, and most of these tumors occur in the sellar and suprasellar regions. Although it rarely occurs in the extracranial region, sphenoid solitary lesions were not reported in previous literature. In this study, we report a case of infrasellar craniopharyngioma within the sphenoid sinus without intracranial lesion. A patient with intermittent headache visited a private clinic and presented with sphenoid lesions based on the Magnetic resonance imaging scan results. The mass was completely removed using endoscopic endonasal transsphenoidal approach without any complications and showed characteristic pathologic findings, which lead to the diagnosis of craniopharyngioma.