bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical treatment of patients with cerebral metastases in the motor area
Authors: Belov D. M. , Karakhan V. B. , Bekyashev A. Кh. , Sevyan N. V. , Aleshin V. A. , Mitrofanov A. A. , Prozorenko E. V. , Sashin D. V. , Garanina N. V. 
Published: April 2022

Introduction. The surgical stage takes an important place in the complex treatment of patients with cerebral metastases of malignant tumors. In general, all efforts during surgical intervention should be aimed at restoring a good functional status, since severe neurological symptoms can deprive patients of the opportunity to continue complex treatment, which will negatively affect overall survival. The most pronounced neurological symptoms are observed in patients with metastases in the motor area. In this article, we tried to substantiate the need for surgery of cerebral metastases in patients with severe motor deficits, evaluate the results of surgical treatment and also to develop optimal surgical removal techniques.The study object – to assess the effectiveness of surgical removal of metastases in the motor cortex by evaluating the dynamics of motor function recovery and regression of paroxysmal symptoms.Materials and methods. An analysis of the surgical treatment of 18 patients with metastases in the motor area was carried out. Tumor localization was verified using magnetic resonance imaging, before surgery, neuronavigation system Brainlab during surgery. Мagnetic resonance tractography made it possible to assess the localization and degree of compression of the fibers of the cortico-spinal tract. Functional monitoring was not performed during the operation. The operations were performed using a ZEISS OPMI PENTERO 800 microscope.Results. Recovery of motor function after surgery was noted in 17 (94.5 %) cases. It was complete or partial. With metastases of a solid, solid-necrotic, solid-cystic structure, regression of pyramidal symptoms developed gradually, starting from 4 days after surgery. As a rule, rehabilitation therapy (therapeutic exercise, massage, electromyostimulation) is carried out on patients from 3 days after surgery, which accelerated the recovery process. The maximum effect developed on the 15th day after the operation. Faster recovery of motor function was observed in patients with large cystic metastases who underwent surgery in the volume of Ommaya reservoir implantation. They began to recover motor function a few hours after awakening. Regression of paroxysmal symptoms was noted in all cases. Although the patients continued to take anticonvulsants. The observation period was 6 months.Сonclusion. Surgical removal of cerebral metastases in the motor area allows achieving complete or partial regression of neurological symptoms. At the same time, the recovery period is short – from several hours to 14 days. It becomes possible to cancel glucocorticoids 7–10 days after the operation. Conditions are being created for the continuation of complex treatment of patients previously considered incurable.
Prevalence and organization problems of medical care to patients with precanceral oral cavity mucosa diseases (on the Tomsk Region example)
Authors: Mikhalev D. E. , Baydik O. D. , Mukhamedov M. R. , Sysolyatin P. G. 
Published: April 2022

Introduction.Nowadays discussed and actual issues of modern oncology are the diagnostics problems and care organization for patients with oral mucosa and lips precancerous diseases.Study purposes– to analyze the prevalence, structure, and primary diagnosis quality of oral mucosa and lips precancerous diseases and to identify the organizing medical care problems for the adult population with the oral cavity precancerous diseases in residents of Tomsk city and Tomsk Region.Materials and methods.For the period 2014–2019 1,664 patients were examined and treated for oral mucosa and lips diseases. The main complaints and medical history were clarified in all patients, according to the recommendations of the World Health Organization, assessed the state of the oral mucosa and lips according to the visual inspection data. To assess the primary diagnosis quality of an oral mucosa disease, we analyzed the data from a dental patient’s medical record, dentist’s referrals, and anamnesis data.Results.In the general oral mucosa and lips pathology structure almost a quarter (25.7 %) of patients were diagnosed with precancerous diseases – leukoplakia (12.5 %), lichen planus (10.8 %), viral papillomas (2.0 %) and Manganotti cheilitis (0.4 %). Malignant neoplasms of the oral cavity at different stages was established in 8.3 % of cases. A retrospective errors analysis revealed that in 100 % of leukoplakia, lichen planus, candidiasis and stomatitis cases the disease form was not indicated. In 22 % cases out of the total number of oral leukoplakia patients, the diagnosis was made mistakenly. In 12 cases of malignant neoplasm underdiagnoses, lichen planus and oral mucosa candidiasis prevailed. In half of the cases of the mistakenly diagnosed oral leukoplakia (10.2 %), oral cavity squamous cell carcinoma was detected. The average waiting time for the oncologist»s appointment was 44.3 ± 10 days.Conclusion.The results indicate a high prevalence of precancerous pathology in the oral mucosa structure diseases(25.7 %) and a long wait for specialized medical care.
A randomized study to evaluate the safety and efficacy of two dosages of lenvatinib – 18 and 24 mg – in patients with radioiodrefract differentiated thyroid cancer
Authors: Brose M. S. , Panaseykin Yu. , Konda B. , De la Fouchardiere C. , Hughes B. G.M. , Gianoukakis A. G. , Park Y. J. , Romanov I. , Krzyzanowska M. K. , Leboulleux S. , Binder T. A. , Dutcus C. , Xie R. , Taylor M. H. 
Published: April 2022

Введение. Ленватиниб является мультикиназным ингибитором, одобренным для лечения радиойодрефрактерного дифференцированного рака щитовидной железы (РЙР-ДРЩЖ) в стартовой дозе 24 мг / день. Данное двойное слепое исследование было проведено с целью определения, будет ли использование ленватиниба в стартовой дозе 18 мг / день наряду со снижением токсичности обеспечивать такую же эффективность, как и его применение в дозе 24 мг / день.Методы. Пациенты с РЙР-ДРЩЖ были рандомизированы в 2 группы в соответствии с дозировкой ленватиниба: 24 и 18 мг / день. Первичной конечной точкой эффективности была частота объективного ответа через 24 нед (ЧОО24 нед). Границей эквивалентности было принято значение 0,4. Первичной конечной точкой безопасности была частота тяжелых (III степени тяжести и выше) нежелательных явлений, возникших после начала лечения (НЯП), по состоянию на 24‑ю неделю. Опухоли оценивались с помощью Критериев оценки ответа солидных опухолей, версия 1.1 (Response Evaluation Criteria In Solid Tumors version 1.1, RECIST 1.1). Нежелательные явления, возникшие после начала лечения, тщательно мониторировались и регистрировались.Результаты. Частота объективного ответа через 24 нед в группе применения ленватиниба в дозе 24 мг / сут составила 57,3 % (95 % доверительный интервал (ДИ) 46,1–68,5), в группе применения ленватиниба в дозе 18 мг / сут – 40,3 % (95 % ДИ 29,3–51,2); отношение шансов (18 / 24 мг) 0,50 (95 % ДИ 0,26–0,96). К 24‑й неделе серьезные НЯП, возникшие после начала лечения, были зафиксированы у 61,3 % пациентов в группе применения ленватиниба в дозе 24 мг / сут и у 57,1 % в группе применения ленватиниба в дозе 18 мг / сут. Разница составила –4,2 % (95 % ДИ 19,8–11,4).Заключение. Использование стартовой дозы ленватиниба 18 мг / сут не продемонстрировало эквивалентной эффективности по сравнению с использованием стартовой дозы 24 мг / сут, что подтверждено показателями ЧОО24 нед у пациентов с РЙР-ДРЩЖ. Была выявлена клинически значимая разница в Ч ОО24 нед. Профили безопасности 2 дозировок ленватиниба были сопоставимыми, клинически значимых различий не наблюдалось. Полученные результаты подтверждают оправданность утвержденной стартовой дозы ленватиниба 24 мг / сут у пациентов с РЙР-ДРЩЖ и дальнейшей ее корректировки по мере необходимости.
Chronicle of the Society of Neurologists and Livers at the Imperial Kazan University of September 10, 1915
Authors: Steinberg S. 
Published: April 2022

Chairperson: V.P. Pervushin, secretaries: M.S. Malinovsky and S.U. Steinberg. In attendance: prof. Gruzdev, prof. Nikolaev, Chirkovsky, Horizontov, Favorsky, Khitrovo, Goryaev, Idelson, Donskov, Klyachkin, Dyakonov, Dyakonov, Semon, Barukh and Berkutov.
The chairman opened the meeting with a proposal to discuss the issue of providing medical assistance to refugees, the wave of which had reached the city of Kazan.
Goals and Practices in Corporate Sustainability Communication: Doğuş Otomotiv Case
Authors: VATANARTIRAN Omer 
Published: April 2022

The concept of sustainability was introduced in 1987 by the United Nations Brundtland Commission,
at a time when global society was experiencing various political, economic and social conflicts. States
developed legal measures for a more sustainable life and placed the topic at the core of their political
agendas. They were followed shortly by non-governmental organizations, municipalities, companies and
the media, who started developing strategies for economic growth that also integrated a sustainable natural
environment and society. Although sustainability practices in the business world sometimes remained
superficial for some companies and did not go beyond an effort to adapt to business trends, the proportion
of corporations that take genuine action for real social change has gradually increased and this has led to
the development of norms in the private sphere. In Turkey, more and more companies have redesigned
their communication strategies in light of the growing awareness around sustainability and the related
social expectations. In this process, it became important to understand the way in which leading companies
experienced this transformation and to what extent they combined sustainability practices with the values
of their stakeholders. With this purpose in mind, this study focuses on Doğuş Otomotiv’s sustainability
values and the communication strategies they implement to spread them. Content analysis was con1ducted
on sustainability reports and websites from a qualitative perspective, and an in-depth interview was held
with a senior Corporate Communications manager. Accordingly, it has been concluded that sustainability
is defined as a participatory, flexible, open communication-based concept among all stakeholders, as well
as a dynamic and broad concept inherent in corporate ethics and company culture. It also appears that sustainability communication takes a different form in different channels depending on the stakeholder
profile, and that in this sense, new media presents both opportunities and challenges.
Porównanie oznaczeń siarkowodoru z użyciem różnych typów detekcji (FPD, TCD) stosowanych w chromatografii gazowej
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Wciślak Agnieszka , Janiga Marek ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Kania Małgorzata ,   Instytut Nafty i Gazu - Państwowy Instytut Badawczy
Published: April 2022

Odpowiedni dobór detektorów w chromatografii gazowej pozwala na dokładniejsze pomiary analizowanych związków. Wybór detektora zależy od substancji, które chcemy oznaczać, od ich procentowej zawartości w analizowanym gazie, a w niektórych przypadkach również od matrycy próbki, w której dany związek się znajduje. Związki siarki są bardzo częstym przedmiotem badań w laboratoriach geochemicznych. Jak dotąd zdecydowanie najpopularniejszym dostępnym na rynku detektorem do pomiaru ich stężeń jest FPD, używany również w Laboratorium Geochemii Nafty i Gazu INiG – PIB. Jednak w zależności od rodzaju i ilości związków siarki można, po opracowaniu odpowiedniej metodyki, użyć również detektorów FID i TCD. Przy badaniu bardzo niskich stężeń siarkowodoru zgodnie z doniesieniami literaturowymi sugerowane jest użycie detektora SCD, a przy badaniach stężeń wysokich można zastosować miareczkowanie jodometryczne. W ramach badań została wykonana kalibracja oraz przeprowadzono elementy walidacji metodyk oznaczania siarkowodoru na zróżnicowanych poziomach stężeń z użyciem detektorów FPD i TCD. Została sprawdzona specyficzność oraz selektywność zastosowanych metodyk badawczych. Ustalono granicę wykrywalności oraz oznaczalności, obliczono powtarzalność, a także liniowość. Kalibracja oraz wybrane elementy walidacyjne pokazały, jakie są możliwości zastosowanych detektorów, a także dały wiedzę, na jakim poziomie należy oznaczać siarkowodór przy użyciu poszczególnych detektorów powszechnie wykorzystywanych w chromatografii gazowej. Wykonane badania udowodniły, że opracowane metodyki spełniają założone kryteria akceptacji dla wybranych elementów walidacji. W wyniku przeprowadzonych badań stwierdzono, że detektor FPD jest adekwatnym wyborem przy badaniach siarkowodoru w zakresie od 1 ppm do 10 ppm, natomiast TCD jest odpowiedni do oznaczeń wyższych stężeń siarkowodoru, tj. od 0,5% do 5%.
Determination of the location of the technological equipment on the chassis of the oil field aggregates
Authors:   Department of Oil Mechanics of Azerbaijan State Oil and Industry University, Hasanov Ramiz , Kazimov Musa ,   Department of Oil Mechanics of Azerbaijan State Oil and Industry University
Published: April 2022

Currently, it is impossible to imagine the repair and drilling of any well without the use of modern mobile equipment. With technological progress, not only new development technologies in the branch of field exploitation appear, but also new equipment with which oil and gas wells are repaired and reconstructed. Today, oil production is mainly carried out by the operation of wells without a pumping derrick, which makes it possible to sharply reduce the cost of metal and funds. Operations of downhole equipment lifting and tripping in a well are carried out using self-propelled mobile units representing tracked or wheeled transport vehicles on which a derrick (mast) with a winch, transmission and hoisting system is mounted. Lifting units are equipped with a mechanism for raising the mast to the working position and lowering it to the transport position. Installations with a lifting capacity of up to 32 tons inclusive are designed for lifting operations during routine underground repair of wells, whereas over 32 tons minimal lift capacity are required during major repairs and well development. The mobile unit is subjected to oscillatory movements both during transportation along unpaved, semi - destroyed, muddy and snow-covered roads to the well (for development, repair), and during well drilling. The frequency of the oscillating movement depends on the state of the uneven road. The unevenness of the road is expressed by spectral functions. In this case, both the chassis and the body of the mobile unit, as well as the technological equipment located on it, are subjected to oscillatory movements. As a result, technological equipment, as well as devices and equipment located on it, lose their accuracy, which leads to accidents both during drilling and during operation. Therefore, in order to minimize the influence of oscillatory movements on the operability of technological equipment, a technique was developed for technological equipment positioning on the chassis of a mobile unit at an optimal scheme according to the proposed method.
Analiza możliwości wykorzystania aparatu PetroOxy do oznaczania stabilności termooksydacyjnej smarów plastycznych metodą RSSOT (Rapid Small-Scale Oxidation Test)
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Sacha Dariusz , Skibińska Agnieszka ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Krasodomski Wojciech ,   Instytut Nafty i Gazu - Państwowy Instytut Badawczy
Published: April 2022

W warunkach eksploatacji smar podlega działaniu szeregu czynników, które powodują jego destrukcję. Smar spełniający swoje podstawowe funkcje w układzie smarowania narażony jest przede wszystkim na działanie wysokiej temperatury, a dominującym procesem starzenia, bezpośrednio wpływającym na okres użytkowania smaru, jest utlenianie. Stabilność termooksydacyjna ma decydujący wpływ na jakość i długość czasu pracy smarów w węzłach tarcia i układach smarowania. W 2018 r. ukazała się nowa procedura badawcza określająca stabilność oksydacyjną smarów plastycznych według normy ASTM D8206 (Standardowa metoda badania stabilności oksydacyjnej smarów – szybki test utleniania w małej skali RSSOT). Metoda badania polega na umieszczeniu badanej próbki smaru plastycznego w ilości 4,00 g (±0,01 g) w szklanym naczynku. Powierzchnia smaru znajdującego się w naczyniu reakcyjnym musi być dobrze wyrównana. Proces ten należy przeprowadzić w temperaturze otoczenia. Szklane naczynie ze smarem plastycznym wkłada się do komory reakcyjnej aparatu badawczego i napełnia komorę tlenem do ciśnienia 700 kPa (±5 kPa). Komora reakcyjna jest ogrzewana do zadanej temperatury (140°C lub 160°C). Ciśnienie w naczyniu jest rejestrowane w odstępach 1 s. Badanie prowadzi się do osiągnięcia punktu końcowego, czyli spadku ciśnienia o 10% od wartości maksymalnej. Test trwa od kilku minut do maksymalnie kilku godzin – w zależności od właściwości badanego obiektu. Artykuł omawia różnice w ocenie stabilności termooksydacyjnej smarów plastycznych oznaczanej wg metody ASTM D8206 z wykorzystaniem dwóch różnych aparatów: PetroOxy i RapidOxy 100. Budowa i sposób działania obu aparatów są zbliżone i zgodne z wymaganiami wyżej wymienionej normy, jednak wyniki uzyskane przy ich wykorzystaniu nie mieszczą się w odtwarzalności metody. W artykule została przedstawiona próba wyjaśnienia przyczyn tego zjawiska.
Note on A Peculiar Fusuline Sample from the Pennsylvanian of the Cantabrian Zone (Spain): Observations and Intriguing Questions
Authors: Villa Elisa , Ueno Katsumi , Merino-Tomé Óscar 
Published: April 2022

ABSTRACT
This paper discusses four peculiar cases of foraminiferal occurrences in a limestone bed of the Pennsylvanian (Myachkovian, upper Moscovian) of the Cantabrian Zone (northern Spain), which raise questions as to their possible interpretation: (1) the true range of the genus Pseudostaffella; (2) the possible marked tendency towards a thickness increase shown by the wall of the genus Putrella; (3) the origin of the apparent deformations observed in part of the fusulines, especially in some Beedeina specimens, here interpreted as alterations probably due to a foraminiferal disease; and (4) the observations made on clusters of recently found fused foraminifera, which invalidate one of the hypotheses so far provided to explain these aggregations while opening perspectives towards new interpretations. A new species, Putrella crassa Villa & Ueno, is introduced.
Identification of biomarkers related to metabolically unhealthy obesity in Korean obese adolescents: A cross-sectional study
Authors: Jeong Sarang , Jang Han Byul , Kim Hyo-Jin , Lee Hye-Ja 
Published: April 2022

Abstract
Background: The current study aimed to screen for relationships and different potential metabolic biomarkers involved between metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) in adolescents.Methods: The study included 148 obese adolescents aged between 14 and 16. The study participants were divided into MUO and MHO groups based on the age-specific adolescent metabolic syndrome (MetS) criteria of the International Diabetes Federation. The current study was conducted to investigate the clinical and metabolic differences between the MHO and MUO groups. Multivariate analyses were conducted to investigate the metabolites as independent predictors for the odds ratio and the presence of the MetS.Results: There were significant differences in the 3 acylcarnitines, 5 amino acids, glutamine/glutamate ratio, 3 biogenic amines, 2 glycerophospholipids, and triglyceride-glucose index between the MUO group and those in the MHO group. Moreover, several metabolites were associated with the prevalence of MUO. Additionally, several metabolites were inversely correlated with MHO in the MUO group.Conclusions: In this study, the biomarkers found in this study have a potential to reflect the clinical outcomes of the MUO group. These biomarkers will lead to a better understanding of MetS in obese adolescents.
Oral Microbial Extracellular DNA as an Initiator of Periodontitis through Gingival Degradation by Fibroblast-derived Cathepsin K
Authors: Kondo Takeru , Okawa Hiroko , Hokugo Akishige , Shokeen Bhumika , Sundberg Oskar , Zheng Yiying , McKenna Charles , Lux Renate , Nishimura Ichiro 
Published: April 2022

Abstract
Periodontitis is a highly prevalent disease leading to uncontrolled osteoclastic jawbone resorption and ultimately to edentulism. While the interaction between dysbiotic biofilm communities and host oral barrier immunity has been extensively studied, much less is known about the disease onset mechanism. We report here its initial pathological mechanism revealed by a new in vivo molecular imaging platform using a highly sensitive, Osteoadsorptive Fluogenic Sentinel (OFS) probe that emits a fluorescent signal triggered by cathepsin K (Ctsk) activity. Unexpectedly, a strong OFS signal was already observed before the establishment of chronic inflammation and bone resorption in a ligature-induced mouse model of periodontitis. Single cell RNA sequencing revealed that the cellular source of early Ctsk was not osteoclasts but gingival fibroblasts. Furthermore, the in vivo OFS signal was activated when Toll-Like Receptor 9 (TLR9) ligand or oral biofilm extracellular DNA (eDNA) was topically applied to the mouse palatal gingiva. By contrast, TLR2/4 ligand and planktonic oral microbial mixture failed to activate the in vivo OFS signal. This previously unrecognized interaction between oral microbial eDNA and gingival Ctsk provides a pathological mechanism for disease initiation and a new strategic basis for early diagnosis and intervention of periodontitis.
Biometric recognition of newborns and young children for vaccinations and health care: A non- randomized prospective clinical trial
Authors: Kalisky Tom , Saggese Steven , Zhao Yunting , Johnson Daniel , Azarova Maya , Duarte-Vera Lilia Edith , Almada-Salazar Lucila Alejandra , Perales-Gonzalez Daniel , Chacon-Cruz Enrique , Wang Jiaxing , Graham Rishi , Hubenko Alexandra , Hall Drew A. , Aronoff-Spencer Eliah 
Published: April 2022

Abstract
Although universal biometrics have been broadly called for, and there are many validated technologies to recognize adults, these technologies have been ineffective in newborns and young children. The present work describes the development and clinical testing of a fingerprint capture system designed explicitly for longitudinal biometric recognition of newborns and young children for vaccination and clinical follow-up. The reader consists of a high-resolution monochromatic imaging system with an ergonomic industrial design to comfortably support and align infant fingers for imaging without a platen. This imaging approach without a platen, also referred to as free space imaging, reduces distortion of the fingerprint and ensures a more consistent finger placement. This system was tested in a newborn ward and immunization clinic at an urban hospital in Baja California, Mexico, from 2017–2019. Nearly five hundred children were enrolled and followed for up to 24 months. With a protocol of imaging all ten fingers, the failure to enroll (FTE) rate was < 1% when acquiring at least two fingers for all ages and < 2% when enrolling at least four fingers. The verification (1:1) true accept rate (TAR) was 77% for newborns enrolled at ≤ 3 days of age and 96% for those enrolled at ≥ 4 days of age, both at a time gap of 15–30 days after enrollment at a False Accept Rate (FAR) of 0.1%. Using the top-ranked match score, the identification rate (1:many) was 86% for the ≤ 3 days enrollment age and 97% for age ≥ 4 days for a single finger at 15–30 days after enrollment. The enrollment protocol and the frequency of updating will increase for infants compared to adults, but these data suggest that a high-resolution, free space imaging technique may fill the final gap for universal biometrics across all populations called for by the United Nations Sustainable Development Goal 16.9.