bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Rehabilitation Exercise Amount on Sleep Quality in Patients with Stroke
Authors: Wang Chien-Hui , Hsu Chien-Ning , Li Hsiao-Mei , Wang Ting-Yi , Hsu Hsiu-Chen , Wu Chiung-Yi , Hsu Yu-Pao , Pan Ren-Hao 
Published: December 2022

Abstract
Objective: Patients with stroke often have accompanying sleep disorders. However, sleep quality plays a crucial role in motor function recovery and brain reorganization. Improving sleep disorders is therefore of great clinical importance. Studies have shown that exercise and increased physical activity have positive effects on sleep disorders and sleep quality. However, studies supporting the use of rehabilitation exercise to achieve a similar effect on sleep quality in patients with stroke are still limited. Therefore, in this study, actigraphy was used to analyze the relationship between the amount and intensity of rehabilitation exercise and sleep. This study contributes to understanding regarding the effects of rehabilitation exercise on sleep quality in patients with stroke.
Methods:An observational study was conducted to investigate the correlation between the amount and intensity of rehabilitation exercise in patients with stroke and their sleep quality.
Results: We observed a positive correlation between moderate- and high-intensity exercise duration and sleep efficiency, but only the correlation between high-intensity exercise duration and sleep efficiency was significant (p≦0.001). We found a negative correlation between high-, moderate-, and low-intensity exercise duration and real sleep time. However, only low-intensity exercise duration was significantly correlated with real sleep time (p≦0.001). We also observed a significant negative correlation between high- (p≦0.001), moderate- (p≦0.001), and low-intensity (p = 0.008) exercise duration and total sleep time. Almost no significant correlation was noted between adjustment factors (gender, age, stroke type, and motor disability severity) and sleep efficiency; we only noted a significant negative correlation between left-sided strokes and sleep efficiency (p = 0.001).
Conclusions: High-intensity rehabilitation exercise had a significant positive effect on sleep efficiency in the observed patients with stroke. Rehabilitation exercise, regardless of its intensity, could reduce required sleep time in the patients with stroke. Furthermore, we recommend instructing patients to engage in not only rehabilitation exercise, but specifically, moderate- or high-intensity rehabilitation exercise, because only such exercise could effectively improve patients’ sleep quality.
Childbirth readiness mediates the effect of social support on psychological birth trauma of primiparous women: a nationwide online cross-sectional study in China
Authors: JU Dandan , ZHANG Ke , YUAN Mengmei , LI Bingbing , ZENG Tieying 
Published: December 2022

Abstract
Background

The detrimental impact of psychological birth trauma is far-reaching for women. This study aimed to identify the relationship between social support, childbirth readiness, and psychological birth trauma and to further explore whether childbirth readiness can play a mediating role.

Methods

A nationwide online cross-sectional study was conducted among 751 primiparous women in seven provinces in China from November 2021 to March 2022. The questionnaire consisted of questions on demographic characteristics, the Psychological Birth Trauma Scale (PBTS), the Chinese Mandarin version of the Medical Outcomes Study Social Support Survey (MOS-SSS-CM), and the Childbirth Readiness Scale (CRS). Hierarchical multiple regression was used to explore the associate factors and mediating role of childbirth readiness in the relationship between social support and psychological birth trauma. The mediating model was examined by the PROCESS macro for SPSS.

Results

After adjusting for demographic variables, social support was negatively associated with psychological birth trauma (r=-0.242, P<0.01). Childbirth readiness had a positive correlation with social support (r = 0.206, P<0.01) and a negative correlation with psychological birth trauma (r=-0.351, P<0.01). The hierarchical multiple regression model indicated that social support and childbirth readiness explained 3.9% and 7.7% of the variance in psychological birth trauma, respectively. Childbirth readiness partly mediated the association between social support and psychological birth trauma for primiparas.

Conclusions

Childbirth readiness played a mediating role between social support and psychological birth trauma among primiparas. Strategies and interventions to enhance childbirth readiness levels may be expected to improve the impact of social support on women's psychological birth trauma.
Effect of nutrient supplements on the depression of the elderly: the mediating effect of physical exercise
Authors: Guo Jianhui , Huang Shuna , Chen Mingjun , Xu Jialiang , Lin Fuxin , Li Huangyuan , Kang Dezhi , Wu Siying 
Published: December 2022

Abstract
Objectives: To explore the association between nutrient supplements and the prevalence of depression. To explore the mediating role of physical exercise in this association.
Methods:Data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were analyzed. A total of 8,427 older adults were included in this study. We used the Center for Epidemiologic Studies Depression Scale (CES-D-10) to assess participants' depression, self-reported use of nutrient supplements as exposure, and self-reported exercise habits to assess participants' physical activity. Logistic regression was used to analyze the association between nutrient supplements and depression. Mediation analysis was used to explore the role of physical activity in this association.
Results: This study found that the use of nutrient supplements was associated with a lower prevalence of depression (OR=0.641, 95% confidence interval [CI]: 0.536-0.766). The prevalence of depression was lower among those who used one or more nutrient supplements compared with those who did not use nutrient supplements. Among the 8 nutrient supplements, calcium, vitamin A/D and other nutrient supplements played a greater role. And physical exercise played a mediating role in the association of nutrient supplements with depression.
Conclusions:Using nutrient supplements could reduce the risk of depression. While using supplements, people should be exercising to promote absorption.
Mechanical protective effect of lens anterior capsule flap on corneal endothelial cells during femtosecond laser-assisted cataract surgery in a rabbit model
Authors: Wu Bowen , Ding Xue , Li Shaowei , Huo Dongmei , Zhang Fan , Liang Weiyan , Li Ling , Dou Zexia 
Published: December 2022

Abstract
Purpose
To evaluate the effects of a novel technique using an isolated lens anterior capsule flap (LACF) to protect corneal endothelial cells in rabbit eyes during femtosecond laser-assisted cataract surgery.
Methods
Experimental study. 40 rabbits were divided into endothelium-protected (experimental) and control groups, with 20 rabbits in each group. In the experimental group, after femtosecond laser capsulotomy, the isolated capsule flap was lifted to the corneal endothelium by an ophthalmic viscosurgical device. The endothelium was damaged for 1 minute with an ultrasonic probe. The control group underwent the same surgery, except that the flap was removed immediately after capsulorhexis. Corneal endothelioscopy was performed preoperatively and on postoperative days (PODs) 3 and 7 to observe endothelial cell counts (ECC) and endothelial cell loss rate (ECL). Central corneal thickness (CCT) was measured before and at PODs 1, 3 and 7.
Results
There were 3.59%±1.88% (p < 0.001) and 2.92%±2.14% (p < 0.001) loss of ECC in experimental group at POD3 and POD7, respectively, while those in the control group were 11.62%±7.43% and 10.34%±5.77%, respectively. On POD 1, the difference in central corneal thickness was significantly (P = 0.019) between the two groups. At POD 3 and POD 7, CCT was not significantly different (P = 0.597;0.913) between the two groups.
Conclusions
The isolated LACF technique significantly reduces damage to the endothelium caused by ultrasonic energy and protects corneal endothelial cells during phacoemulsification.
Reclaimed Water in Taiwan: Current Status and Future Prospects
Authors: Cheng Hai-Hsuan , Yu Wan-Shen , Tseng Shu-Chuan , Wu Yi-Ju , Hsieh Ching-Lin , Lin Shi-Shuan , Chu Ching-Ping , Huang Yu-De , Chen Wan-Ru , Lin Tsair-Fuh , Whang Liang-Ming 
Published: December 2022

Abstract
The Taiwan Water Resources Agency of Ministry of Economic Affairs indicates the average water demand shortage is 530.6 million m3/yr during 2011 to 2019, and this shortage situation will be more serious in the near future due to global climate change. The reclaimed water in Taiwan, therefore, has been considered as new water sources mainly for industrial consumers for manufacturing processes, especially those high-tech industries in science parks. In order to meet the targeted reclaimed water supply of 1.32 million CMD in 2031, Taiwan currently focuses on two major reclaimed water sources, including reclaimed water from the high water-consuming industries and municipal wastewater treatment plants. This report reviews current technologies used for reclaimed water including units for pretreatment, desalting, polishing, and reclamation. Cases studies in Taiwan including reclaimed water from high water-consuming industries such as thin film transistor-liquid crystal display (TFT-LCD) and semiconductor industries and from municipal wastewater treatment plants are presented. Finally, challenges and future prospects for promoting reclaimed water to fulfill the targeted reclaimed water supply in 2031 are discussed.
Clinical value of PEX7 in Coronary Artery Heart Disease patients: Bioinformatics-based approach
Authors: Ji Xiang , Shi Lin , Xi Qian , Liu Yang 
Published: December 2022

Abstract
Background
Coronary Artery Heart Disease (CHD) is a chronic inflammatory and fibroproliferative disease background on aberrant lipid metabolism, and the focus in trending research is the mechanism of unstable plaque generated by immune-related inflammation. Identifying the mechanism of plaque-related immune infiltration is crucial for mitigating the negative effects of coronary artery disease.
Methods
The Gene Expression Omnibus (GEO) database was used to download the expression data for the CHD and control samples. The Limma R program was used to find differentially expressed genes (DEGs) between CHD and control samples. The ssGESA technique was used to examine the enrichment of 28 cell types in CHD and control samples. Using weighted gene co-expression network analysis (WGCNA), it was possible to identify modules that were important to the cell types that were differentially enriched. Following the discovery of overlapping DEGs and genes by WGCNA, a protein-protein interaction (PPI) network was built to identify hub genes. In order to assess the diagnostic utility of hub genes, ROC curves were generated. Additionally, the TF-mRNA and miRNA-mRNA regulatory networks were built and visualized by Cytoscape software, and the miRNA and TF targeting of diagnostic hub genes were predicted using the web tools miRNet and NetworkAnalyst.
Results
A total of 9485 DEGs were identified in CHD database. The results of immune cell infiltration revealed that the abundance of T follicular helper cells, type 1 T helper cells, and immature dendritic cells varied significantly between samples. The extensive immunological mechanism demonstrates the pathway involved by immune related DEGs(IR-DEGs)was primarily enriched in the peroxisome-mediated immune metabolism. Among the 421 CHD-related IR-DEGs identified, PEX6, SCP2, PEX7, PECR, SRP54, and PEX10 occupy key positions in the PPI network, featuring PEX7 as the core and five others as its interconnected genes. The ROC curve revealed that, with the exception of PECR, the other five genes had diagnostic value in the progression of CHD. The constructed miRNA and TF regulatory network model suggest that PEX7 may be casCHDed with SCP2 and PEX10 via h6a-mir-124-3p and FOXL1, which imply a molecular framework for PEX-related path.
Conclusion
Our research has elucidated the diagnostic relevance of immune-related genes, indicating that PEX7, as a potential biomarker, plays a significant role in the immune metabolism-related mechanism of CHD via the peroxisome-mediated pathway.
Landward mantle flow associated with the Pacific subduction system opened the South China Sea
Authors: Suo Yanhui , Dong Hao , Liu Lijun , Peng Diandian , Li Yanchong , Liu Jinping , Dai Liming , Cao Xianzhi , Li Sanzhong 
Published: December 2022

Abstract
Whether Tethyan or Pacific subduction controlled the formation of the South China Sea (SCS) is debated. Here, using high resolution seismic data, we reveal that the continental extension across the northern SCS margin experienced a transition from the Early-Eocene narrow-rift mode to the Late Eocene wide-rift mode. Using 4D geodynamic models, we propose that the evolving rifting mode was dominated by the landward mantle flow associated with Pacific subduction: 1) Toroidal mantle flow through a hole in the retreating flat slab initially thinned the continent to form a narrow rift; 2) Strong landward mantle wind through a broad trench-parallel slab window since ~40 Ma stretched the narrow rift into a wide rift and eventually an oceanic basin. We conclude that the landward mantle flow represents a new mechanism of continental extension, where increasingly strong hot upwelling caused the intermediate SCS rifted margin between the traditional magma-poor and magma-rich end-members.
"Family and society empowerment": Abused women's exclusive needs during pregnancy- A qualitative study
Authors: Barez Malikeh Amel , Najmabadi Khadijeh Mirzaii , Roudsari Robab Latifnejad , Bazaz Mojtaba Mousavi , Babazadeh Raheleh 
Published: December 2022

Abstract
Background
Domestic violence threatens maternal physical, psychological and emotional safety. Abused pregnant women required several interventions based on their actual needs with the purpose of reducing domestic violence and its negative consequences. The present study aimed to explore the exclusive needs of abused pregnant women in Iran.
Methods
This qualitative study was performed from September 2019 to August 2021 in Mashhad, Iran. Semi-structured interviews with 14 abused women (8 pregnant and 6 after birth) who were the victims of domestic violence, and 11 key informants with various discipline specialties until the data saturation was achieved. Participants were selected through purposive sampling. Qualitative data were analyzed based on the conventional content analysis adopted by Graneheim & Lundman.
Findings:
"Family and society empowerment" was the main concept emerged from the data analysis comprising of three categories such as "need to empower couples to reduce domestic violence during pregnancy", "demand for improved health care services", and "need to strengthen inter-sectoral, legal and social supports".
Conclusion
Abused pregnant women experienced several individual, interpersonal and inter sectoral needs. Family and society empowerment constituted the actual needs of abused pregnant women. Awareness of policymakers and health system managers of these needs could be the basis for designing a supportive care program according to abused women’s actual needs. In addition to the educational and skill empowerment of couples, it is essential that supportive organizations cooperate with each other to provide integrated and coordinated services to abused pregnant women and strengthen and facilitate maternal access to supportive resources.
Multiple redox switches of the SARS-CoV-2 main protease in vitro provide new opportunities for drug design
Authors: Tittmann Kai , Funk Lisa-Marie , von Pappenheim Fabian Rabe , Wensien Marie , Eulig Nora , Penka Elke , Stegmann Kim , Dickmanns Antje , Dobbelstein Matthias , Mata Ricardo , Uranga Jon , Bazzi Sophia , Fritz Tobias , Chari Ashwin , Paknia Elham , Heyne Gaby , Pearson Arwen , Hilgenfeld Rolf , Curth Ute , Berndt Carsten , Poschmann Gereon 
Published: December 2022

Abstract
Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for stopping the current COVID-19 pandemic and preventing future outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine protease with essential functions in viral replication, has been validated as an effective drug target. Here, we show that Mpro is subject to redox regulation in vitro and reversibly switches between the enzymatically active dimer and the functionally dormant monomer through redox modifications of cysteine residues. These include a disulfide-dithiol switch between the catalytic cysteine C145 and cysteine C117, and generation of an allosteric cysteine-lysine-cysteine SONOS bridge that is required for structural stability under oxidative stress conditions, such as those exerted by the innate immune system. We identify homo- and heterobifunctional reagents that mimic the redox switching and inhibit Mpro activity. The discovered redox switches are conserved in main proteases from other coronaviruses, e.g. MERS-CoV and SARS-CoV, indicating their potential as common druggable sites.
Measurement of pressure–volume–temperature diagrams based on simulated melt temperature and actual cavity pressure
Authors: Zhu Bo-Wei , Nian Shih-Chih , Huang Ming-Shyan 
Published: December 2022

Abstract
Pressure–volume–temperature (pvT) diagrams illustrate the behavior of a polymer melt during injection molding and can be used to determine the optimal process parameter settings for producing quality parts. However, the measurements of pvT diagrams are costly and time-consuming and have limitations for process control. This study generated an economic pvT diagram based on sensor data and simulation analysis. To avoid the use of expensive infrared sensors and inaccurate pressure simulations, a pvT curve was constructed by combining the melting temperature, which was simulated using computer-aided engineering, and the actual cavity pressure. The specific volume of the polymer melt was then calculated using a modified Tait model. The pvT diagram could be used to investigate the changes in specific volume at various injection stages, which could be applied to quality prediction. In this study, a flat plate with uneven thickness was used as the research vehicle. The specific volume of each sensor position of the plastic component cooled to room temperature was calculated. Thereafter, a correlation analysis between the changes in specific volume and the shrinkage ratio of the plastic part was conducted. The experiment indicated that both variables were highly correlated. Therefore, monitoring changes in specific volume could predict part size. Additionally, the proposed measurements of the pvT diagram could be used to compute the cooling time, which greatly affects the quality and production efficiency of injection-molded parts. A 25-s cooling time setting demonstrated a stable molding quality compared with the traditional heat transfer formula (16 s) and the commercial simulation (17 s).
Design optimization and experiment of corn U-shaped fertilization device
Authors: Zuo Zheng , Zhao Jianguo , Yin Baozhong , Li Lixia , Jia Hetong , Zhang Baochuan , Ma Zhikai , Hao Jianjun , Wang Zhenyang 
Published: December 2022

Abstract
Aiming at the problems of low utilization rate of corn fertilizer, low precision of fertilization ratio, and time-consuming and laborious topdressing in the later stage, an U-shaped fertilization device with uniform fertilizer mechanism was designed. The device was mainly composed of uniform fertilizer mixing mechanism, fertilizer guide plate and fertilization plate. Compound fertilizer was applied on both sides and slow/controlled release fertilizer was applied at the bottom to form an U-shaped distribution of fertilizer around corn seeds. Through theoretical analysis and calculation, the structural parameters of the fertilization device were determined. Through the simulated soil tank test, the quadratic regression orthogonal rotation combination design was carried out on the main factors affecting the spatial stratification effect of fertilizer. The optimal parameters were obtained as follows: the stirring speed of the stirring structure was 300 r/min, the bending angle of the fertilization tube was 165°, and the operating speed of the fertilization device was 3 km/h. The results of bench verification test showed that under the optimized stirring speed and bending angle, the fertilizer particles were stirred evenly, and the average values of fertilizer flowing out of the fertilization tubes on both sides were 299.5 g and 297.4 g, respectively. The average fertilizer amounts of the three fertilizer outlets were 200.4 g, 203.2 g and 197.7 g, respectively, which met the agronomic requirements of 1:1:1 fertilization, and the variation coefficients of fertilizer amounts on both sides of the fertilizer pipe and each layer were less than 0.1% and 0.4%, respectively. The simulation results of the optimized U-shaped fertilization device can achieve the expected U-shaped fertilization effect around corn seeds. The results of field experiment showed that the U-shaped fertilization device could realize the U-shaped proportional application of fertilizer in soil. The distance between the upper end of fertilization on both sides and the distance between the base fertilizer and the surface were 87.3 ~ 95.2 mm and 197.8 ~ 206.0 mm, respectively. The transverse distance between the fertilizers on both sides was 84.3 ~ 99.4 mm, and the error with the designed theoretical fertilization was within 10 mm. Compared with the traditional side fertilization method, the number of corn roots increased by 5 ~ 6, the root length increased by 30 ~ 40 mm, and the yield increased by 9.9 ~ 14.8 %.
Analysis of the correlation between biomechanical properties and corneal densitometry in myopic eyes
Authors: Zheng Yuwei , Xue Chao , Wang Jing , Chen Xuan , Wang Xiaohui , Wang Yan 
Published: December 2022

Abstract

Background
To investigate the correlation between corneal biomechanical characteristics (in vitro and in vivo) and corneal densitometry in myopia.
Methods
The Pentacam (Oculus, Wetzlar, Germany) corneal densitometry (CD) and Corvis ST (Oculus, Wetzlar, Germany) exams were conducted prior to surgery for myopic patients who were intended to undergo small-incision lenticule extraction (SMILE). CD values (grayscale units, GSUs), CCT (central corneal thickness) and in vivo biomechanical parameters were obtained. The stromal lenticule was subjected to a uniaxial tensile test to obtain the elastic modulus E in vitro. To exam correlations among biomechanical characteristics, CCT and CD values.
Results
In this study, 37 myopic patients (63 eyes) were included. The mean age of participants was 25.14 ± 6.74 years (range:16–39 years). The mean CD values of the total cornea, anterior layer, intermediate layer, posterior layer, 0–2 mm region and 2–6 mm region were 15.03 ± 1.23 GSU, 20.35 ± 1.98 GSU, 11.76 ± 1.01 GSU, 10.95 ± 0.83 GSU, 15.57 ± 1.12 GSU and 11.94 ± 1.77 GSU, respectively. Elastic modulus E (in vitro biomechanical indicator) was negatively correlated with intermediate layer CD (r=-0.35, P = 0.01) and 2–6 mm region CD (r=-0.39, P = 0.00). A negative correlation was also found between 0–2 mm central region CD and in vivo biomechanical indicator SP-HC (r=-0.29, P = 0.02). CCT was correlated with multiple biomechanical characteristics in vivo but didn’t interfere in vitro biomechanical indicator.
Conclusions
In myopic patients, densitometry is negatively correlated with biomechanical properties both in vivo and in vitro. With an increase in CD, the cornea deformed more easily. Elastic modulus can exclude the influence of CCT on corneal mechanics.