bluuebunny/crossref_metadata_2025_split huggingface dataset:
The perceived value of book borrowing services is stationary in the time of Covid-19: Empirical evidence from the Municipal Library in Prague
Authors: Stejskal Jan , Zapletal David , Prokop Viktor 
Published: July 2022

Public libraries represent a specific sector of public service provision, where library management is limited in its ability to influence consumers’ perceptions of the value of borrowed books. This study expands previous research on consumers’ perceived value and its measurement and focuses on the nature of the data examined, which has not yet received much attention. We fill this research gap and examine whether the perceived value of book borrowing services remains stationary over time by considering a sample of readers from the Municipal Library in Prague, Czech Republic. Moreover, we analyse whether the Covid-19 pandemic has affected the perceived value of book borrowing services. Our results contribute to the discussion an important finding that consumers’ perceptions of book borrowing services are stable and do not change over time. Interestingly, we also find that the Covid-19 pandemic has not led to a change in consumers’ perceived value. This study thus creates both theoretical and practical contributions and leads to the definition of several practical implications for managers of (public) library organisations. JEL L86, H39, H44
The MSIS-29 and SF-36 as outcomes in secondary progressive MS trials
Authors: Strijbis Eva MM , Repovic Pavle , Mostert Jop , Bowen James D , Uitdehaag Bernard MJ , Cutter Gary , Koch Marcus W 
Published: July 2022

Background: Patient-reported outcome measures (PROMs) are often used in clinical research, but little is known about their performance as longitudinal outcomes. Methods: We used data from ASCEND, a large SPMS trial ( n = 889), to investigate changes on the Short Form Health Survey 36 (SF-36 v2) and the Multiple Sclerosis Impact Scale (MSIS-29) over 2 years of follow-up. Results: PROM scores changed little over the 2 years of follow-up. In contrast to physical disability measures, there was no consistent trend in PROM change: significant worsening occurred about as often as improvement. Using a 6-month confirmation reduced the number of both worsening and improvement events without altering their relative balance. There was no clear difference in worsening events in groups based on population characteristics, nor was there a noticeable effect using different thresholds for clinically significant change. Conclusion: We found little consistent change in MSIS-29 and SF-36 over 2 years of follow-up in people with SPMS. Our findings show a disconnect between disability worsening and PROM change in this population. Our findings raise caution about the use of these PROMs as primary outcome measures in SPMS trials and call for a critical reappraisal of the longitudinal use of these measures in SPMS trials.
The Profile of Articles on AXIN2 Mutations, Oligodontia, and Ethical Statements in Dental Research
Authors: Constance Wiener R. 
Published: July 2022

Purpose Editors often require ethical statements in research publications. This is particularly important with genetic data where discrimination may occur upon data disclosures. The purpose of this research is to determine if there was a positive trend of publishing ethical statements in dental genetic research. The study is limited to AXIN2 mutations which may be associated with oligodontia and cancer. Methods A MEDLINE search of 2011–2021 articles concerning AXIN2, oligodontia, and ethical statements was conducted. Reviews, nonhuman subject research, abstracts, and articles not written nor translated into English were excluded. Results Forty-four studies were found; 10 excluded. There were 25 (75.8%) with ethical statements, and 25 (75.8%) with participant consent statements. There was no significant difference by year in ethical statements over the ten years (p = 0.094). Conclusion There is a need to encourage more ethical statements in publications especially for genetically sensitive topics to reassure readers of ethical practices.
Cross-Cultural Adaptation, Validation, and Reliability of the Persian Version of the Brief Michigan Hand Questionnaire
Authors: Shariatzadeh Hooman , Najd Mazhar Farid , Fathi Choghadeh Meysam , Kachooei Amir R. 
Published: July 2022

Background: Brief Michigan Hand Questionnaire (Brief MHQ) is one of the most reliable and sensitive patient-reported outcome measures for hand and wrist disorders worldwide. This study aimed to assess the psychometric properties of the Persian version of the Brief Michigan Hand Questionnaire based on standard guidelines. Methods: One hundred two patients with various hand and wrist disorders filled the Persian version of Brief MHQ along with the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) questionnaire and the visual analogue scale (VAS) for pain. Seventy-eight participants returned to complete the Persian Brief MHQ for the second time after 4 days. Results: The analysis showed excellent internal consistency with a Cronbach’s alpha ranging from 0.89 to 0.91. The Persian Brief MHQ has an excellent test-retest reliability with a 0.94 intraclass correlation coefficient (ICC). The correlation coefficient of -0.74 between Brief MHQ and the QuickDASH showed a strong correlation and confirmed its validity. Conclusion: The Persian version of the Brief MHQ is a reliable and valid tool to apply to Persian individuals with hand and wrist disorders.
Accuracy and Glycemic Efficacy of Continuous Glucose Monitors in Critically Ill COVID-19 Patients: A Retrospective Study
Authors: Boeder Schafer , Kobayashi Emily , Ramesh Gautam , Serences Brittany , Kulasa Kristen , Majithia Amit R. 
Published: July 2022

Background: Continuous glucose monitoring (CGM) is approved for insulin dosing decisions in the ambulatory setting, but not currently for inpatients. CGM has the capacity to reduce patient-provider contact in inpatients with coronavirus disease 2019 (COVID-19), thus potentially reducing in hospital virus transmission. However, there are sparse data on the accuracy and efficacy of CGM to titrate insulin doses in inpatients. Methods: Under an emergency use protocol, CGM (Dexcom G6) was used alongside standard point-of-care (POC) glucose measurements in patients critically ill from complications of COVID-19 requiring intravenous (IV) insulin. Glycemic control during IV insulin therapy was retrospectively assessed comparing periods with and without adjunctive CGM use. Accuracy metrics were computed and Clarke Error Grid analysis performed comparing CGM glucose values with POC measurements. Results: Twenty-four critically ill patients who met criteria for emergency use of CGM resulted in 47 333 CGM and 5677 POC glucose values. During IV insulin therapy, individuals’ glycemic control improved when CGM was used (mean difference –30.7 mg/dL). Among 2194 matched CGM: POC glucose pairs, a high degree of concordance was observed with a mean absolute relative difference of 14.8% and 99.5% of CGM: POC pairs falling in Zones A and B of the Clarke Error Grid. Conclusions: Continuous glucose monitoring use in critically ill COVID-19 patients improved glycemic control during IV insulin therapy. Continuous glucose monitoring glucose data were highly concordant with POC glucose during IV insulin therapy in critically ill patients suggesting that CGM could substitute for POC measurements in inpatients thus reducing patient-provider contact and mitigating infection transmission.
Sexual and reproductive health service needs among youths attending preparatory school in Debre Tabor Town, Northwest Ethiopia
Authors: Adane Metages , Cherie Niguss , Damtie Yitayish , Malde Mulusew , Chanie Muluken Genetu 
Published: July 2022

Objective: Despite the reproductive health needs of youth having been supported by different organizations, youths continue to fall victim to sexual and reproductive health problems, and utilization of those services remains low. All efforts have not been felt across the Ethiopian learning institutions as is evidenced by persistent reproductive health problems. This study was aimed to determine sexual and reproductive health service needs among preparatory school youths of Debre Tabor town, Ethiopia. Methods: Facility-based cross-sectional study design was conducted in Debre Tabor town from 15 to 30 February 2020. A simple random sampling technique was used to access a total of 850 preparatory school students. The data were collected using pre-tested, structured, and self-administered questionnaires. Data were entered into EpiData v. 4.6 and exported to SPSS version 25 software for analysis. Binary logistics regression was used for analysis. Adjusted odds ratio along with 95% confidence interval was estimated to measure the strength of the association. The level of statistical significance was declared at a p value of 0.05. Results: The overall magnitude of sexual and reproductive health service needs was found 61.5% at 95% confidence interval (58.2%, 64.8 %). Being married (adjusted odds ratio = 2.24; 95% confidence interval: 1.10, 4.55), having information about sexual and reproductive health (adjusted odds ratio = 2.56; 95% confidence interval: 1.85, 3.55), youth discussion with families on sexual and reproductive health (adjusted odds ratio = 1.52, 95% confidence interval: 1.11, 2.10), and having a history of sexual intercourse (adjusted odds ratio = 2.19; 95% confidence interval: 1.53, 3.13) were found significantly associated with sexual and reproductive health service needs of youths. Conclusion: the overall need for sexual and reproductive health services among youths was found high. Therefore, managers and health workers need to prioritize an intervention that can improve youth-friendly service, information dissemination, and counseling, promoting discussion among family members on the sexual and reproductive health needs of the youths.
Dynamic Postural Stability Is Decreased During the Single-Leg Drop Landing Task in Male Collegiate Soccer Players With Chronic Ankle Instability
Authors: Kawaguchi Kohei , Taketomi Shuji , Mizutani Yuri , Inui Hiroshi , Yamagami Ryota , Kono Kenichi , Kage Tomofumi , Takei Seira , Fujiwara Sayaka , Ogata Toru , Tanaka Sakae 
Published: July 2022

Background: Chronic ankle instability (CAI) is commonly encountered in soccer players. The feelings of instability and anxiety caused by CAI can lead to poor performance, such as difficulty in sharp change of direction during soccer play. The single-leg drop landing (SLDL) task is often used to evaluate dynamic postural stability. Purpose/Hypothesis: The purpose of this study was to clarify whether dynamic stability measured during SLDL is altered in male collegiate soccer players with CAI. The hypothesis was that athletes with CAI would show poor dynamic postural stability. Study Design: Controlled laboratory study. Methods: A total of 103 male collegiate soccer players were recruited, and their limbs were classified based on the new international CAI criteria. All players performed three 5-second SLDL trials on a force plate. The main outcome measures included time to stabilization of the horizontal ground-reaction force (GRF); peak GRF in the vertical, horizontal, and sagittal directions; and trajectory length of the center of pressure during SLDL. Results: Data from 59 CAI limbs and 147 non-CAI limbs were collected in this study. Time to stabilization of horizontal GRF was significantly longer in the CAI limbs ( P < .001), and the peak GRFs in all directions were significantly lower in the CAI limbs (vertical, P < .001; horizontal, P < .001; sagittal, P = .001). Additionally, the trajectory length of the center of pressure was significantly greater in the CAI limbs ( P = .004). Conclusion: Soccer players with CAI had decreased dynamic postural stability that led them to land softly when performing the SLDL task. Measurement of dynamic postural stability may be useful in the evaluation of CAI. Clinical Relevance: Our findings may be useful for strategies of daily training or as an evaluation tool.
Prevalence and clinical associations with primary hypogonadism in male systemic sclerosis
Authors: Thepwiwatjit Sapol , Charoensri Suranut , Sirithanaphol Wichien , Mahakkanukrauh Ajanee , Suwannaroj Siraphop , Foocharoen Chingching 
Published: July 2022

Background: Systemic sclerosis may affect male and female fertility. Premature ovarian failure has been reported in female systemic sclerosis patients, but the effects on male fertility in systemic sclerosis have not been studied. Objectives: We aimed to determine the prevalence and clinical associations with primary hypogonadism among male systemic sclerosis patients. Methods: This was a cross-sectional pilot study, including 30 adult male systemic sclerosis patients attending the Scleroderma Clinic, Khon Kaen University. Testosterone deficiency symptoms were assessed using the Aging Males’ Symptoms Rating Scale, urological examination, and blood testing (for total testosterone, free testosterone, follicle-stimulating hormone, and luteinizing hormone). We excluded patients with congenital hypogonadism and any acquired disorders of the testes and genitalia. The definition of primary hypogonadism was based on the International Society for the Study of the Aging Male 2015 diagnostic criteria for hypogonadism. Results: Seven patients met the definition of primary hypogonadism—a prevalence of 23.3% (95% confidence interval: 9.9–42.3). The respective mean age and mean systemic sclerosis duration was 59.4 ± 11.9 and 5.5 ± 4.7 years. Older age at onset, high triglyceride level, and older age starting corticosteroid treatment were significantly associated with primary hypogonadism ( p = 0.02, 0.02, and 0.03, respectively). Systemic sclerosis subset, disease severity, and immunosuppressant use were not associated with primary hypogonadism among Thai male systemic sclerosis patients. Conclusion: Around one-quarter of male systemic sclerosis patients had primary hypogonadism. Elderly onset of systemic sclerosis, hypertriglyceridemia, and late corticosteroid treatment were risk factors for developing primary hypogonadism.
Minor Salivary Gland Biopsy in Diagnosis of Sjögren’s Syndrome
Authors: Gordon Alex J. , Patel Aneek , Zhou Fang , Liu Cheng , Saxena Amit , Rackoff Paula , Givi Babak 
Published: July 2022

ObjectivePrevious studies have questioned the safety and efficacy of minor salivary gland biopsy in the diagnosis of Sjögren’s syndrome, citing complications and difficulty of pathologic evaluation. This study aims to determine the rate of biopsy specimen adequacy and the risk of complications after minor salivary gland biopsy.Study DesignCase series.SettingSingle tertiary care center.MethodsWe reviewed the records of all patients who underwent minor salivary gland biopsy at our institution from October 1, 2016, to September 1, 2021. Demographics, comorbidities, symptoms, and serologic results were recorded. The primary outcome was adequacy of the tissue sample. Complications of the procedure were recorded. Biopsies with at least one focus of ≥50 lymphocytes per 4‐mm2 sample were considered positive.ResultsWe identified 110 patients who underwent minor salivary gland biopsy. Ninety‐three (85%) were female, and the median age was 49.1 years (range, 18.7‐80.5). Seventy‐seven procedures (70%) were performed in the office setting, and 33 (30%) were performed in the operating room. Nearly all biopsy samples (n = 108, 98%) were adequate, and 33 (31%) were interpreted as positive. Four patients (4%) experienced temporary lip numbness, which resolved with conservative management. No permanent complications were reported after lip biopsy. Nineteen (58%) patients with positive biopsy results had no Sjögren’s‐specific antibodies. Most patients with positive biopsy results (n = 20, 61%) subsequently started immunomodulatory therapy.ConclusionMinor salivary gland biopsy can be performed safely and effectively in both the office and the operating room. This procedure provides clinically meaningful information and can be reasonably recommended in patients suspected to have Sjögren’s syndrome.
The role of allogeneic transplant for adult Ph+ ALL in CR1 with complete molecular remission: a retrospective analysis
Authors: Ghobadi Armin , Slade Michael , Kantarjian Hagop , Alvarenga Julio , Aldoss Ibrahim , Mohammed Kahee A. , Jabbour Elias , Faramand Rawan , Shah Bijal , Locke Frederick , Fingrut Warren , Park Jae H. , Short Nicholas J. , Gao Feng , Uy Geoffrey L. , Westervelt Peter , DiPersio John F. , Champlin Richard E. , Al Malki Monzr M. , Ravandi Farhad , Kebriaei Partow 
Published: July 2022

AbstractHistorically, Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) has been associated with poor outcomes, and allogeneic hematopoietic cell transplantation (allo-HCT) is recommended in first complete remission (CR1). However, in the tyrosine kinase inhibitor (TKI) era, rapid attainment of a complete molecular remission (CMR) is associated with excellent outcomes without allo-HCT, suggesting transplant may not be required for these patients. To test this hypothesis, we retrospectively identified adult patients with Ph+ ALL treated with induction therapy, including TKIs, and attained CMR within 90 days of diagnosis at 5 transplant centers in the United States. We compared outcomes of those who did and did not receive allo-HCT in first remission. We identified 230 patients (allo-HCT: 98; non-HCT: 132). The allo-HCT cohort was younger with better performance status. On multivariable analysis (MVA), allo-HCT was not associated with improved overall survival (adjusted hazard ratio [aHR]: 1.05; 95% CI, 0.63-1.73) or relapse-free survival (aHR: 0.86; 95% CI, 0.54-1.37) compared with non-HCT treatment. Allo-HCT was associated with a lower cumulative incidence of relapse (aHR: 0.32; 95% CI, 0.17-0.62) but higher non-relapse mortality (aHR: 2.59; 95% CI, 1.37-4.89). Propensity score matching analysis confirmed results of MVA. Comparison of reduced-intensity HCT to non-HCT showed no statistically significant difference in any of the above endpoints. In conclusion, adult patients with Ph+ ALL who achieved CMR within 90 days of starting treatment did not derive a survival benefit from allo-HCT in CR1 in this retrospective study.
miR167d-ARFs Module Regulates Flower Opening and Stigma Size in Rice
Authors: Zhao Zhi-Xue , Yin Xiao-Xiao , Li Sha , Peng Yu-Ting , Yan Xiu-Lian , Chen Chen , Hassan Beenish , Zhou Shi-Xin , Pu Mei , Zhao Jing-Hao , Hu Xiao-Hong , Li Guo-Bang , Wang He , Zhang Ji-Wei , Huang Yan-Yan , Fan Jing , Li Yan , Wang Wen-Ming 
Published: July 2022

AbstractFlower opening and stigma exertion are two critical traits for cross-pollination during seed production of hybrid rice (Oryza sativa L.). In this study, we demonstrate that the miR167d-ARFs module regulates stigma size and flower opening that is associated with the elongation of stamen filaments and the cell arrangement of lodicules. The overexpression of miR167d (OX167d) resulted in failed elongation of stamen filaments, increased stigma size, and morphological alteration of lodicule, resulting in cleistogamy. Blocking miR167d by target mimicry also led to a morphological alteration of the individual floral organs, including a reduction in stigma size and alteration of lodicule cell morphology, but did not show the cleistogamous phenotype. In addition, the four target genes of miR167d, namely ARF6, ARF12, ARF17, and ARF25, have overlapping functions in flower opening and stigma size. The loss-of-function of a single ARF gene did not influence the flower opening and stigma size, but arf12 single mutant showed a reduced plant height and aborted apical spikelets. However, mutation in ARF12 together with mutation in either ARF6, ARF17, or ARF25 led to the same defective phenotypes that were observed in OX167d, including the failed elongation of stamen filaments, increased stigma size, and morphological alteration of lodicule. These findings indicate that the appropriate expression of miR167d is crucial and the miR167d-ARFs module plays important roles in the regulation of flower opening and stigma size in rice.
Computational method using heterogeneous graph convolutional network model combined with reinforcement layer for MiRNA–disease association prediction
Authors: Huang Dan , An JiYong , Zhang Lei , Liu BaiLong 
Published: July 2022

AbstractBackgroundA large number of evidences from biological experiments have confirmed that miRNAs play an important role in the progression and development of various human complex diseases. However, the traditional experiment methods are expensive and time-consuming. Therefore, it is a challenging task that how to develop more accurate and efficient methods for predicting potential associations between miRNA and disease.ResultsIn the study, we developed a computational model that combined heterogeneous graph convolutional network with enhanced layer for miRNA–disease association prediction (HGCNELMDA). The major improvement of our method lies in through restarting the random walk optimized the original features of nodes and adding a reinforcement layer to the hidden layer of graph convolutional network retained similar information between nodes in the feature space. In addition, the proposed approach recalculated the influence of neighborhood nodes on target nodes by introducing the attention mechanism. The reliable performance of the HGCNELMDA was certified by the AUC of 93.47% in global leave-one-out cross-validation (LOOCV), and the average AUCs of 93.01% in fivefold cross-validation. Meanwhile, we compared the HGCNELMDA with the state‑of‑the‑art methods. Comparative results indicated that o the HGCNELMDA is very promising and may provide a cost‑effective alternative for miRNA–disease association prediction. Moreover, we applied HGCNELMDA to 3 different case studies to predict potential miRNAs related to lung cancer, prostate cancer, and pancreatic cancer. Results showed that 48, 50, and 50 of the top 50 predicted miRNAs were supported by experimental association evidence. Therefore, the HGCNELMDA is a reliable method for predicting disease-related miRNAs.ConclusionsThe results of the HGCNELMDA method in the LOOCV (leave-one-out cross validation, LOOCV) and 5-cross validations were 93.47% and 93.01%, respectively. Compared with other typical methods, the performance of HGCNELMDA is higher. Three cases of lung cancer, prostate cancer, and pancreatic cancer were studied. Among the predicted top 50 candidate miRNAs, 48, 50, and 50 were verified in the biological database HDMMV2.0. Therefore; this further confirms the feasibility and effectiveness of our method. Therefore, this further confirms the feasibility and effectiveness of our method. To facilitate extensive studies for future disease-related miRNAs research, we developed a freely available web server called HGCNELMDA is available athttp://124.221.62.44:8080/HGCNELMDA.jsp.