bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of first versus second line sacrocolpopexies in terms of morbidity and mid-term efficacy
Authors: Lallemant Marine , Grob A. T. M. , Puyraveau M. , Perik M. A. G. , Alhafidh A. H. H. , Cosson M. , Ramanah R. 
Published: September 2022

AbstractTo compare pelvic organ prolapse (POP) recurrence and morbidity between first and second line sacrocolpopexies. We conducted a retrospective chart review of all laparoscopic or robotic sacrocolpopexies for POP-Q stage ≥ 2, with or without a history of previous prolapse repair, performed with a similar technique between January 2012 and June 2019 in 3 European Gynecologic Surgery Departments. Patients were separated into two groups: first line sacrocolpopexy (FLS) and second line sacrocolpopexy (SLS). Each patient from the SLS group was age-matched with a patient from the FLS group. The primary outcome measure was reoperation procedures for recurrent POP defined as a symptomatic POP-Q stage ≥ 2 POP in at least one vaginal compartment. Secondary outcomes included operative time, intraoperative organ trauma, intraoperative blood loss, postoperative POP recurrence (operated on or not), global reoperation and mesh-related complications. During this period, 332 patients were included. After age-matching, 170 patients were analyzed: 85 patients in the FLS and SLS groups, respectively. After a mean follow-up of 3 years, there was no statistically significant difference between the two groups in terms of recurrent POP (9.4% versus 10.6%, p = 0.7), recurrent POP reoperation (3.5% versus 5.9% p = 0.7), mesh-related reoperation (0% versus 2.4%, p = 0.5), global reoperation (3.5 versus 8.2%, p = 0.3), operative time (198 ± 67 min versus 193 ± 60 min, p = 0.5), intraoperative complications such as organ injury (4.7% versus 7.1%, p = 0.7) and blood loss > 500 mL (2.4% versus 0%, p = 0.5). Patients who underwent a first or a second line sacrocolpopexy seemed to have similar rates of prolapse recurrence and complications.
High frequency of Nichols-like strains and increased levels of macrolide resistance in Treponema pallidum in clinical samples from Buenos Aires, Argentina
Authors: Morando Nicolas , Vrbová Eliška , Melgar Asunta , Rabinovich Roberto Daniel , Šmajs David , Pando María A. 
Published: September 2022

AbstractGlobally, 94% of Treponema pallidum subsp. pallidum (TPA) clinical strains belong to the SS14-like group and 6% to the Nichols-like group, with a prevalence of macrolide resistance of 90%. Our goal was to determine whether local TPA strain distribution and macrolide resistance frequency have changed significantly since our last report, which revealed that Buenos Aires had a high frequency of Nichols-like strains (27%) and low levels of macrolide resistance (14%). Swab samples from patients with suspected syphilis were collected during 2015–2019 and loci TP0136, TP0548, TP0705 were sequenced in order to perform multilocus sequence typing. Strains were classified as Nichols-like or SS14-like. The presence of macrolide resistance-associated mutations was determined by examination of the 23S rDNA gene sequence. Of 46 typeable samples, 37% were classified as Nichols-like and 63% as SS14-like. Macrolide resistance prevalence was 45.7%. Seven allelic profiles were found, five were SS14-like and two were Nichols-like. The frequency of Nichols-like strains increased between studies (26.8% vs. 37%, p = 0.36). A dramatic increase was found in the frequency of macrolide resistant strains between studies (14.3% vs. 45.7%, p = 0.005). Our results are in agreement with international trends and underscore the need to pursue further TPA molecular typing studies in South America.
Artificial intelligence-enhanced volumetric laser endomicroscopy improves dysplasia detection in Barrett’s esophagus in a randomized cross-over study
Authors: Kahn Allon , McKinley Matthew J. , Stewart Molly , Wang Kenneth K. , Iyer Prasad G. , Leggett Cadman L. , Trindade Arvind J. 
Published: September 2022

AbstractVolumetric laser endomicroscopy (VLE) is an advanced endoscopic imaging tool that can improve dysplasia detection in Barrett’s esophagus (BE). However, VLE scans generate 1200 cross-sectional images that can make interpretation difficult. The impact of a new VLE artificial intelligence algorithm called Intelligent Real-time Image Segmentation (IRIS) is not well-characterized. This is a randomized prospective cross-over study of BE patients undergoing endoscopy who were randomized to IRIS-enhanced or unenhanced VLE first followed by the other (IRIS-VLE vs. VLE-IRIS, respectively) at expert BE centers. The primary outcome was image interpretation time, which served as a surrogate measure for ease of interpretation. The secondary outcome was diagnostic yield of dysplasia for each imaging modality. 133 patients were enrolled. 67 patients were randomized to VLE-IRIS and 66 to IRIS-VLE. Total interpretation time did not differ significantly between groups (7.8 min VLE-IRIS vs. 7 min IRIS-VLE, P = 0.1), however unenhanced VLE interpretation time was significantly shorter in the IRIS-VLE group (2.4 min vs. 3.8 min, P < 0.01). When IRIS was used first, 100% of dysplastic areas were identified, compared with 76.9% when VLE was the first interpretation modality (P = 0.06). IRIS-enhanced VLE reduced the time of subsequent unenhanced VLE interpretation, suggesting heightened efficiency and improved dysplasia detection. It was also able to identify all endoscopically non-visible dysplastic areas.
High-efficiency near-infrared optical parametric amplifier for intense, narrowband THz pulses tunable in the 4 to 19 THz region
Authors: Seo Meenkyo , Mun Je-Hoi , Heo Jaeuk , Kim Dong Eon 
Published: September 2022

AbstractDynamic control of material properties using strong-field, narrowband THz sources has drawn attention because it allows selective manipulation of quantum states on demand by coherent excitation of specific low-energy modes in solids. Yet, the lack of powerful narrowband lasers with frequencies in the range of a few to a few tens of THz has restricted the exploration of hidden states in condensed matter. Here, we report the optimization of an optical parametric amplifier (OPA) and the efficient generation of a strong, narrowband THz field. The OPA has a total conversion efficiency of > 55%, which is the highest value reported to date, with an excellent energy-stability of 0.7% RMS over 3 h. We found that the injection of a high-energy signal beam to a power amplification stage in an OPA leads to high-efficiency and a super-Gaussian profile. By difference-frequency generation of two chirped OPA signal pulses in an organic nonlinear crystal, we obtained a THz pulse with an energy of 3.2 μJ, a bandwidth of 0.5 THz, and a pulse duration of 860 fs tunable between the 4 and 19 THz regions. This corresponds to an internal THz conversion efficiency of 0.4% and a THz field strength of 6.7 MV/cm. This approach demonstrates an effective way to generate narrow-bandwidth, intense THz fields.
Role of modified nasopharyngeal oxygen therapy in apnoeic oxygenation under general anaesthesia: a single-centre, randomized controlled clinical study
Authors: Geng Weilian , Chen Changxing , Chen Yaobing , Yu Xinhua , Huang Shaoqiang 
Published: September 2022

AbstractApnoeic oxygenation is not only important for patients who cannot be intubated/ventilated, but also can be routinely employed when planning to secure the airway.We aimed to compare safe apnoea times between patients receiving modified nasopharyngeal oxygen therapy and those receiving high-flow nasal oxygen therapy (HFNO) following the induction of general anaesthesia.This was a single-centre, randomized controlled clinical study. Eighty-four female patients undergoing elective laparoscopic gynaecological surgery under general anaesthesia were randomly assigned to the high-flow nasal oxygen therapy group (Group HFNO) or the modified nasopharyngeal oxygen therapy group (Group Naso). A Kaplan–Meier survival curve was used to describe the apnoeic oxygenation time.The safe apnoea time of the patients in the Group Naso was higher than that of the patients in the Group HFNO (20 (19.3 to 20.0) vs. 16.5 (12.9 to 20) minutes, P < 0.05). The incidence of SpO2 < 95% in the Group Naso was lower than that in the Group HFNO; hazard ratio 0.3 (95% confidence interval 0.2 to 0.6, P < 0.0001). Modified nasopharyngeal oxygen therapy which uses far less oxygen than HFNO is a convenient and effective method of apnoeic oxygenation in normal female patients.Trial registration: https://www.chictr.org.cn, ChiCTR2000039433; date of registration: 28/10/2020.
High-fidelity quantum information transmission using a room-temperature nonrefrigerated lossy microwave waveguide
Authors: Qasymeh Montasir , Eleuch Hichem 
Published: September 2022

AbstractQuantum microwave transmission is key to realizing modular superconducting quantum computers and distributed quantum networks. A large number of incoherent photons are thermally generated within the microwave frequency spectrum. The closeness of the transmitted quantum state to the source-generated quantum state at the input of the transmission link (measured by the transmission fidelity) degrades due to the presence of the incoherent photons. Hence, high-fidelity quantum microwave transmission has long been considered to be infeasible without refrigeration. In this study, we propose a novel method for high-fidelity quantum microwave transmission using a room-temperature lossy waveguide. The proposed scheme consists of connecting two cryogenic nodes (i.e., a transmitter and a receiver) by the room-temperature lossy microwave waveguide. First, cryogenic preamplification is implemented prior to transmission. Second, at the receiver side, a cryogenic loop antenna is placed inside the output port of the waveguide and coupled to an LC harmonic oscillator located outside the waveguide. The loop antenna converts quantum microwave fields to a quantum voltage across the coupled LC harmonic oscillator. Noise photons are induced across the LC oscillator including the source generated noise, the preamplification noise, the thermal occupation of the waveguide, and the fluctuation-dissipation noise. The loop antenna detector at the receiver is designed to extensively suppress the induced photons across the LC oscillator. The signal transmittance is maintained intact by providing significant preamplification gain. Our calculations show that high-fidelity quantum transmission (i.e., more than $$95\%$$

95
%

) is realized based on the proposed scheme for transmission distances reaching 100 m.
Shortening and re-lengthening versus bone transport for the treatment of distal tibial periarticular post-traumatic defects
Authors: Huang Qiang , Ma Teng , Ren Cheng , Xu YiBo , Li Ming , Wang Qian , Lu Yao , Li Zhong , Zhang Kun 
Published: September 2022

AbstractIn the present study, we presented our experience with a new modified technique of shortening and re-lengthening using a monolateral external frame combined with a calcaneal intramedullary nail and compared it with the bone transport technique for the treatment of distal tibial periarticular post-traumatic defects. Forty-one patients were retrospectively analyzed. Among them 19 were treated using our modified shortening and re-lengthening technique (MSR group) and 22 by bone transport (BT group). The difference in external fixation time (EFT), external fixation index (EFI), self-rating anxiety scale (SAS), and complications were compared between the two groups. The mean EFT was 3.4 ± 0.6 months in the MSR group and 7.5 ± 1.4 months in the BT group; the EFI was 0.57 ± 0.06 month/cm and 1.32 ± 0.23 month/cm, respectively. The EFT, EFI, and SAS scores were significantly lower in the MSR group than in the BT Group (p < 0.05). The mean number of complications per patient in the BT group was nearly 2.4 times that of the MSR group (p < 0.05). Our modified shortening and re-lengthening technique reduced the EFI and complication incidence compared to the bone transport technique. Therefore, patients with distal tibial periarticular post-traumatic defects can achieve great satisfaction with this new technique.
p38MAPK guards the integrity of endosomal compartments through regulating necrotic death
Authors: Yao Jia , Atasheva Svetlana , Toy Randall , Blanchard Emmeline L. , Santangelo Philip J. , Roy Krishnendu , Mocarski Edward S. , Shayakhmetov Dmitry M. 
Published: September 2022

AbstractPathogens trigger activation of sensors of the innate immune system that initiate molecular signaling enabling appropriate host defense programs. Although recognition of pathogen-specific moieties or PAMPs by specialized receptors of the immune system is well defined for a great number of pathogens, the mechanisms of sensing of pathogen-induced functional perturbations to the host cell remain poorly understood. Here we show that the disruption of endosomal compartments in macrophages by a bacterium or fully synthetic nanoparticles activates stress-response p38MAPK kinase, which triggers execution of cell death of a necrotic type. p38MAPK-mediated necrosis occurs in cells with a compound homozygous deletion of pyroptosis-inducing caspases-1 and -11, apoptotic caspase-8, and necroptosis-inducing receptor-interacting protein kinase-3 (RIPK3), indicating that all of these principal cell death mediators are dispensable for p38MAPK-induced necrosis in response to endosome rupture. p38MAPK-mediated necrosis is suppressed by the receptor-interacting protein kinase 1, RIPK1, and degradation of RIPK1 sensitizes macrophages to necrotic death. Since pathogen-induced cell death of necrotic types is implicated in host defense against infection, our results indicate that functional perturbations in host cells are sensed as a component of the innate immune system.
m6A RNA methylation regulator-related signatures exhibit good prognosis prediction ability for head and neck squamous cell carcinoma
Authors: Zhai Yujia , Zheng Lian 
Published: September 2022

AbstractHead and neck squamous cell carcinoma (HNSCC) has become the sixth most common malignant disease worldwide and is associated with high mortality, with an overall 5-year survival rate of less than 50%. Recent studies have demonstrated that aberrantly expressed m6A regulators are involved in multiple biological and pathological processes, including cancers, but the specific mechanisms of m6A regulators in HNSCC are not well elucidated. In this study, we adopted The Cancer Genome Atlas (TCGA)-HNSCC database and performed a consensus clustering analysis to classify the HNSCC samples. Least absolute shrinkage and selection operator (LASSO) regression was applied to construct an m6A signature-based HNSCC risk prediction model. Cell type identification based on estimating relative subsets of RNA transcripts (CIBERSORT) algorithms was adopted to evaluate the immune cell infiltration level in the tumor microenvironment. Based on the expression of m6A regulators in HNSCC, we identified two clusters, cluster 1 (C1) and cluster 2 (C2). C2 showed a better prognosis than C1 and was mainly enriched in the HIPPO, MYC, NOTCH, and NRF signaling pathways. We constructed an m6A signature-based risk score model and classified patients into high- and low-risk score subgroups. The high-risk-score group showed poor clinical characteristics, higher immune infiltration levels, higher chemokine and chemokine receptor expression levels, and lower immune checkpoint gene expression than the low-risk-score subgroup. In conclusion, our comprehensive analysis suggests that the m6A signature-based risk score might function as a good prognostic predictor. Our study may provide novel therapeutic clues and help predict the prognosis of HNSCC.
Metal–organic framework (MOF)-5/CuO@ZnIn2S4core–shell Z-scheme tandem heterojunctions for improved charge separation and enhanced photocatalytic performance
Authors: Yang Yi , Xing Zipeng , Kong Weifeng , Wu Chunxu , Peng Hui , Li Zhenzi , Zhou Wei 
Published: September 2022

Metal-organic framework (MOF)-5/CuO@ZnIn2S4core-shell Z-scheme tandem heterojunctions with photothermal effects are prepared by solvothermal and oxidative composite methods to promote spatial charge separation and light utilization.
Low‐carbon operation method of the building based on dynamic carbon emission factor of power system
Authors: Bu Le , Chen Xingying , Gan Lei , Yu Kun , Zhou Yue , Cao Jiawei , Cao Yuan 
Published: September 2022

AbstractEnergy conservation and carbon reduction in building energy is an important way to achieve the global goal of ‘carbon neutrality’. Common low‐carbon operation strategies of buildings rely on price incentives to guide users’ behaviour, which is difficult to make users aware of the impact of their energy consumption behaviour on carbon emissions. In this paper, the power system's dynamic carbon emission factors (CEF) were used to release information on energy consumption and carbon emission to building users. At the same time, the differential effects of building envelope and external temperature in the Building Information Modelling were considered. An optimisation method of building low‐carbon energy consumption strategy considering both the building and power carbon emission was established to improve the comprehensive carbon reduction ability of the building and power system. The simulation results show that the proposed method effectively coordinates the building virtual energy storage and demand response. By incorporating the dynamic energy carbon transaction cost into the objective function, the target signal of carbon reduction is transmitted to users so that the volatility of the renewable Energy and other random energy behaviours can be considered in the dynamic CEF.
The Choice between Plasma-Based Common Coagulation Tests and Cell-Based Viscoelastic Tests in Monitoring Hemostatic Competence: Not an either–or Proposition
Authors: Bunch Connor M. , Berquist Margaret , Ansari Aida , McCoy Max L. , Langford Jack H. , Brenner Toby J. , Aboukhaled Michael , Thomas Samuel J. , Peck Ethan , Patel Shivani , Cancel Emily , Al-Fadhl Mahmoud D. , Zackariya Nuha , Thomas Anthony V. , Aversa John G. , Greene Ryan B. , Seder Christopher W. , Speybroeck Jacob , Miller Joseph B. , Kwaan Hau C. , Walsh Mark M. 
Published: September 2022

AbstractThere has been a significant interest in the last decade in the use of viscoelastic tests (VETs) to determine the hemostatic competence of bleeding patients. Previously, common coagulation tests (CCTs) such as the prothrombin time (PT) and partial thromboplastin time (PTT) were used to assist in the guidance of blood component and hemostatic adjunctive therapy for these patients. However, the experience of decades of VET use in liver failure with transplantation, cardiac surgery, and trauma has now spread to obstetrical hemorrhage and congenital and acquired coagulopathies. Since CCTs measure only 5 to 10% of the lifespan of a clot, these assays have been found to be of limited use for acute surgical and medical conditions, whereby rapid results are required. However, there are medical indications for the PT/PTT that cannot be supplanted by VETs. Therefore, the choice of whether to use a CCT or a VET to guide blood component therapy or hemostatic adjunctive therapy may often require consideration of both methodologies. In this review, we provide examples of the relative indications for CCTs and VETs in monitoring hemostatic competence of bleeding patients.
Ultrasound Changes of Postoperative Adhesion Types Over Time in Children
Authors: Alamdaran Seyed Ali , Vahed Seyed Hamidreza , Seyedin Golnaz 
Published: September 2022

AbstractPostoperative fibrotic band formation is a common complication that causes bowel obstruction, chronic pain, and especially reoperation problems. We tried to evaluate the ultrasound signs of different adhesions over time in children. This descriptive study was performed in children hospital of Mashhad University of Medical Sciences. Sixty-five children aged 4 months to 15 years (mean age of 7.2 ± 6.5 years) were enrolled in the study. Complete abdominal sonography using 5 to 12 MHz multifrequency probes was performed by a pediatric radiologist. The sonographic findings and data analysis were performed. In first week after surgery, the fibrinous exudates are seen as hypoechoic shadows. It has uneven thickness and usually encases the bowel loops in a circular shape. In second week, they gradually become straighter with uniform thickness. In this period, in 68% of cases, a hyperechoic line is formed in the center of hypoechoic fibrinous exudates, which is usually placed between the bowel loops (interloop fibrosis). The omentum or mesentery entrapment in the fibrinous exudates was occurred in ∼50% and 25% of these cases, respectively. In this state, echogenic omentum or mesentery was seen simultaneously with the hypoechoic fibrinous exudates. After 1 month from surgical procedure, One of the following four sonographic patterns are seen: attachment hyperechoic omentum to retroperitoneum (50%), attachment hyperechoic mesentery to anterior abdominal wall (26%), interloop fibrosis (39%), and severe hypoechoic fibrotic band (30%). Absence of visceral sliding was seen in 65 to 80% of patients. Overall, there are five morphologic patterns of adhesion on ultrasound: fibrinous exudates, interloop fibrosis, fibrotic band, fixed omentum to retroperitoneum, and fixed mesentery to abdominal wall.
Nonlinear dynamic behavior of a dual-rotor bearing system with coupling misalignment and rubbing faults
Authors: Kuan Lu , Hui Cheng , Wentao Zhang , Haopeng Zhang , Kaifu Zhang , Chao Fu 
Published: September 2022

Abstract
Taking the dual-rotor system in an aero-engine as a research object, the vibration behaviors of a dual-rotor bearing system that is fault-free or has misalignment, rub-impact or misalignment rub-impact coupling faults are studied, respectively. First, the three-dimensional model of the dual rotor bearing system is established, and then the first six modes and critical speeds of the dual rotor bearing system are obtained by the finite element method. Then, the dynamic equations of the dual rotor bearing system with and without faults are derived based on the Lagrange method. The Runge–Kutta method is used to solve the dynamic equation, and the nonlinear dynamic response of the system is obtained. The vibrational behaviors of the dual rotor system with misalignment, rub-impact and misalignment rub-impact coupling faults are analyzed and discussed through the time history, phase diagram and frequency spectrum of the rotor. The vibrational behaviors of the first six modes of the dual rotor system with and without faults are analyzed, respectively. The results provide theoretical guidance for the structural optimization design of an aero-engine rotor system and the prior decision information for misalignment and rub-impact coupling fault diagnosis.