bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a novel rapid genomic test including polygenic risk scores for the diagnosis and management of familial hypercholesterolaemia
Authors: Neves Emma , Khan Tina , Williams Maggie , Carrera Marta , Banya Winston , Brugada Ramon , Ferrer Carles , Morris-Rosendahl Deborah J , Barbir Mahmoud 
Published: August 2022

Introduction: Familial hypercholesterolaemia (FH) is a common autosomal dominant genetic condition, characterised by elevated LDL cholesterol (LDL-C), leading to premature cardiovascular disease (CVD). Early and accurate diagnosis, with implementation of preventative therapies, has a major impact on reducing premature CVD, morbidity and mortality.Genetic testing is recommended to confirm clinical diagnosis in the proband and enable cascade testing in relatives. There is growing evidence that the risk of CVD conferred by hypercholesterolaemia depends not only on monogenic causes but also on polygenic factors. GENinCode has developed a novel genomic testing system (Lipid inCode®) which we have assessed against an accredited National Health Service (NHS UK) genetic screening service in order to validate its diagnostic and clinical utility.Methods: DNA samples from 40 index cases who had been referred for FH testing in an ISO15189-accredited NHS genetic screening service, were retrospectively tested using the Lipid inCode® assay. The results were compared with those from NHS testing. Results: There was absolute concordance in variant detection between both diagnostic tests for monogenic and polygenic FH, the only difference being in the interpretation and classification of DNA variants based on ACMG guidelines, which did not differ by more than one classification class. The Lipid inCode® test was equivalent to the NHS test in providing comprehensive genetic analysis that included the assessment of both monogenic (FH) and polygenic determinants of blood cholesterol and including a pharmacogenomic assessment of predisposition to statin-related myopathy.Conclusion: The Lipid inCode® diagnostic test can be undertaken with rapid turnaround and gave the same results as those reported by standard NHS genetic laboratory testing. In addition to assessment of monogenic FH, the Lipid inCode® assay provides additional genetic data, such as polygenic factors contributing to hypercholesterolaemia, a polygenic risk score (PRS) for coronary artery disease (CAD), pharmacogenomic testing for statin myopathy, and genetic predisposition to raised Lp(a).
From Fleming to Endo: The discovery of statins
Authors: Chester Adrian 
Published: August 2022

Statins are now one of the most prescribed drugs in the world and have had a major impact in the prevention and treatment of cardiovascular disease, thereby extending the lives of millions of people across the world. The scientist responsible for the discovery of the first statin, Professor Akira Endo, was recently honoured for ‘exceptional contribution to cardiovascular medicine’ by award of the European Society of Cardiology 2021 Gold Medal (REF).
Enhancing Food Intake Tracking in Long-term Care With Automated Food Imaging and Nutrient Intake Tracking (AFINI-T) Technology: Validation and Feasibility Assessment
Authors: Pfisterer Kaylen , Amelard Robert , Boger Jennifer , Keller Heather , Chung Audrey , Wong Alexander 
Published: August 2022

Background
Half of long-term care (LTC) residents are malnourished, leading to increased hospitalization, mortality, and morbidity, with low quality of life. Current tracking methods are subjective and time-consuming.

Objective
This paper presented the automated food imaging and nutrient intake tracking technology designed for LTC.

Methods
A needs assessment was conducted with 21 participating staff across 12 LTC and retirement homes. We created 2 simulated LTC intake data sets comprising modified (664/1039, 63.91% plates) and regular (375/1039, 36.09% plates) texture foods. Overhead red-green-blue-depth images of plated foods were acquired, and foods were segmented using a pretrained food segmentation network. We trained a novel convolutional autoencoder food feature extractor network using an augmented UNIMIB2016 food data set. A meal-specific food classifier was appended to the feature extractor and tested on our simulated LTC food intake data sets. Food intake (percentage) was estimated as the differential volume between classified full portion and leftover plates.

Results
The needs assessment yielded 13 nutrients of interest, requirement for objectivity and repeatability, and account for real-world environmental constraints. For 12 meal scenarios with up to 15 classes each, the top-1 classification accuracy was 88.9%, with mean intake error of −0.4 (SD 36.7) mL. Nutrient intake estimation by volume was strongly linearly correlated with nutrient estimates from mass (r2=0.92-0.99), with good agreement between methods (σ=−2.7 to −0.01; 0 within each of the limits of agreement).

Conclusions
The automated food imaging and nutrient intake tracking approach is a deep learning–powered computational nutrient sensing system that appears to be feasible (validated accuracy against gold-standard weighed food method, positive end user engagement) and may provide a novel means for more accurate and objective tracking of LTC residents’ food intake to support and prevent malnutrition tracking strategies.
The Pragmatic Return to Effective Dental Infection Control Through Triage and Testing (PREDICT) Study: Protocol for a Prospective Clinical Study in the National Dental Practice–Based Research Network
Authors: Fredericks-Younger Janine , Fine Daniel H , Subramanian Gayathri , Coker Modupe O , Meyerowitz Cyril , Ragusa Patricia , Allareddy Veerasathpurush , McBurnie Mary Ann , Funkhouser Ellen , Gennaro Maria Laura , Feldman Cecile A 
Published: August 2022

Background
Dental practice has been greatly affected by the COVID-19 pandemic. As SARS-CoV-2 infection is transmitted by respiratory fluids, dental practice techniques, which include aerosol-generating procedures, can increase the risk of transmission causing heightened safety concerns for both dental health care workers (DHCWs) and patients. These concerns have resulted in the reduction in patient volume and the available workforce within dental practices across the United States. Standardized methods for COVID-19 triage and testing may lead to increased safety and perceptions of safety for DHCWs and their patients and promote willingness to provide and access oral health care services.

Objective
This study is designed to develop procedures that test the feasibility of enhanced COVID-19 triage and testing in dental offices. It will provide preliminary data to support a larger network-wide study grant application aimed at developing protocols to address safety concerns of patients and DHCWs in a peri–COVID-19 pandemic era.

Methods
The feasibility study is being conducted in 4 private dental practices, each of which has a dentist member of the National Dental Practice–Based Research Network. Participants include the DHCWs and patients of the dental practice. Study procedures include completion of COVID-19 triage, completion of COVID-19 testing (point-of-care [POC] or laboratory-based [LAB] SARS-CoV-2 viral, antigen, and antibody tests based on office designation), and administration of perception and attitude surveys for participating DCHWs and patients of the dental practice over a defined study period. The office designation and the participant’s role in the practice determines which testing protocol is executed within the office. There are 4 study groups following 4 distinct protocols: (1) POC DHCWs, (2) POC patients, (3) LAB DHCWs, and (4) LAB patients.

Results
Data collection began in December of 2021 and concluded in March 2022. Study results are expected to be published in fall 2022.

Conclusions
The results of this feasibility study will help identify the viability and functionality of COVID-19 triage and testing in dental practices and inform a larger network-wide study grant application that develops protocols that address safety concerns of patients and DHCWs in a COVID-19 environment.

Trial Registration
ClinicalTrials.gov NTC05123742; https://clinicaltrials.gov/ct2/show/NCT05123742?term=NCT05123742

International Registered Report Identifier (IRRID)
DERR1-10.2196/38386
HUBUNGAN ANTARA KESADARAN DIRI DAN PENYESUAIAN DIRI DENGAN KEDISIPLINAN MENERAPKAN PROTOKOL KESEHATAN DI ERA NEW NORMAL
Authors: Sari Novita , Kholifah Nanik 
Published: August 2022

Currently, all countries in the world are experiencing disaster, namely Covid-19 including Indonesia. Government has imposed restrictions by imposing a new normal policy. However, the positive number of Covid-19 is still soaring in May-July 2021, this is presumably due toÂ industrial sector is still open as usual, where employees who work violate the rules that have been set. Thus this is related to employee discipline in complying with health protocols. This study aims to determine the relationship of self-awareness and adjustment to the discipline of using health protocols in the normal era. Subjects in this study were 84 employees of PT. Duta Beton Mandiri, using accidental sampling as a sampling technique. Data collection uses a discipline scale, self-awareness scale, and self-adjustment scale. Discipline scale there are 36 items with reliability of 0,898, self-awareness scale there are 34 items with reliability of 0,911, and self-adjustment scale, there are 36 items with reliability of 0,891. Data analysis technique using multiple regression analysis. From calculation results, F value is 31,532 with p = 0,000 (p Ë‚ 0,05), so there are is a very significant correlation between self-awareness and self-adjustment to discipline of using health protocols in the new normal era. Thus self-awareness and adjustment affect individuals in applying the discipline of health protocols.
Pelaksanaan Pembelajaran Kolase Dalam Meningkatkan Motorik Halus Anak Usia Dini di RA Perwanida Miri
Authors: TRIMUKTI NDARU 
Published: August 2022

AbstrackNdaru Trimukti, The implementation collage learning to crease early childhoodâ€™s fine motor, thesis: Early childhood education programâ€™s, Tarbiyah Sciene faculty and teacher training, IAIN Surakarta, April 2017.Keyword: collage activity, Childhoodâ€™s fine MotorThe problem of this research is different development fine motor abiliy of early childhood.There are some children who has stiff arm, this research are knowing the development of hand flexibility and hand and eyes coordination of early chilhoodâ€™s fine motor with collage learningThe research used action research method. Researcher subject was teacher. Receiver subject was students. Data was collected by using practical test, observation, documentation and interview. The sucsess of this research was in good growing category.The result of this research can be concluded that collage learning in increasing early childhoodâ€™s fine motor. In the first cycle, the children who developed according expectation 20% and developed very good was 45%. While in the second cycle, children who developed according expectation was 10% and developed very good was 75%. So, in this action research, the developing of fine motor early chilhood has reached indicator of success.Â Â Â Â Â Â Â Â Â Â ABSTRAKNdaruTrimukti, Pelaksanaan Pembelajaran Kolase Dalam meningkatkan motorik Halus anak usia dini, Skripsi: Jurusan Pendidikan Islam Anak Usia Dini, Fakultas Ilmu Tarbiyah dan Keguruan, IAIN Surakarta, April 2017.Kata Kunci : Kolase, Motorik Halus Anak Usia Dini.Masalah dalam Penelitian ini adalah siswa RA Perwanida Miri memiliki perkembangan kemampuan motorik halus yang belum merata. Ada beberapa yang memiliki kelenturan tangan yang masih kaku. Tujuan penelitian ini adalah untuk mengetahui kelenturan tangan dan koordinasi mata dan tangan pada anak dengan pembelajaran kolase.Penelitian ini menggunakan Penelitian Tindakan Kelas. Subyek penelitian adalah guru. Subyek penerima tindakan adalah siswa. Data dikumpulkan dengan menggunakan tes praktek, observasi, dokumentasi dan wawancara. Data yang sudah terkumpul dianalisis dengan model analisis interaktif. Keberhasilan ditandai dengan indikator kinerja yaitu 75% anak berada pada Kategori berkembang sangat baik.Penelitian menyimpulkan bahwa pembelajaran kolase dapat meningkatkan kelenturan tangan dan koordinasi mata dan tangan, ditandai pada setiap siklus dalam tindakan. Siklus I kategori berkembang sesuai harapan 20% dan berkembang sangat baik. Sedangkan Siklus II kategori berkembang sesuai harapan 10% dan berkembang sangat baik 75%. Sehingga tindakan ini perkembangan motorik halus anak telah mencapai indikator keberhasilan yang telah ditentukan.
NILAI FEMINISME KISAH PEREMPUAN DALAM AL QURAN
Authors: Sifa Layyina 
Published: August 2022

Everything about women and womenhood are always interesting to discuss either from economic, social, edocational or theological aspect. Some discourses should be discussed in order to present thoughts, theories or policies friendly to womenâ€™s right and to avoid Â inequality in gender. The most interesting issue relate to theological framework. Religious text is often claimed to be one source of women discrimination and gender inequality. Some stories in religious text (al Quran) such as story of creation of Adam and Hawa and story of Maryam contain ideas that woman is a second human and that she gets subordination and injustice treatment. Actually, there are lot of researches about story of Quran (qashash al Quran), but they often stuck on the historical and chronological discussion. They forget some values behind those stories especially stories about women. Women as main figure surely has a special role to show the main value for women justice and equal right. The main cause of those discriminative interpretaion is that; most of Quranic interpreters are man, therefore, the result of interpretion is not considering womenâ€™s right. And the other cause is the use of israiliyyat stories which often blame and underestimate womenâ€™s position. Thus, we need to present new interpretaion of stories in the Quran, especially stories on women that we hope such new interpretation will giveÂ new toughtsÂ and policies for women justice and equal right.
Women Heroes Behind Martin Luther Kingâ€™s Civil Disobedience As One Of Major Moments In American History
Authors: Sucipto Sucipto 
Published: August 2022

Women in America has long history and journey towards their independent and rights, especially black women or African-American women. Their struggle for justice and equality has faced many challenges and turmoils ever since its movement begun. One of the movementsÂ was The Civil Rights movements by the mid of 20thÂ century. Martin Luther King, Jr.Â was an African-American who vocalizedÂ in initiating and fighting for Civil Rights fromÂ black peopleÂ community. His dedication for liberty and equality without segregation and racism is acknowledged to American and also has been used for references for many scholars in different fields of studyÂ globally. This paper is qualitative descriptive which focuses on describing the Women HeroesÂ and their contributionsÂ behind Martin Luther King, Jrâ€™s journey to struggle forÂ Civil Rights in America. The findings shows that there are at least three heroes; Rosa Louise McCauley a.k.a Rosa Parks, Constance Baker Motley, and Coretta Scott King who did not only show their courage but also bring huge impacts to legalize the Civil Rights Movement.Â Rosa Parks acted as symbol of civil rights movements supported by Montley as their legal supporter, and also Coreta who had given her many intellectual thoughts to King. Their dedications were undenialiable and became spirit for African-American rights up until now. This paper contributes to further readings about civil rights movement and its features, especially women heroes behind the movement.
Pendidikan Seks untuk Anak Usia Dini di Masa Pendemi Covid-19
Authors: Purwasih Wahyu 
Published: August 2022

AbstractThis study explains the preventive measures taken by families to prevent sexual abuse. While the majority of people still think that only mothers are responsible for caring. Not all fathers understand that between father and mother have the same portion of parenting. Therefore, this study aims to determine the role of fathers and mothers in providing sex education as a preventive measure to prevent sexual crimes. This research method uses literacy studies. The results of this study indicate that the roles of fathers and mothers in preventing sexual crimes can be divided into two broad lines. The first plays a role in building children's feelings, the second plays a role in giving skills to children when facing danger. When a child has got these two roles from father and mother, he will be able to feel that he is valuable and able to avoid sexual abuse.Â AbstrakTulisan ini menjelaskan upaya preventif yang dilakukan keluarga untuk mencegah terjadinya kejahatan seksual. Sedangkan mayoritas masyarakat masih beranggapan bahwa yang bertugas mengasuh hanya ibu. Belum semua ayah memahami bahwa antara ayah dan ibu memiliki porsi yang sama dalam pengasuhan. Oleh karena itu, penelitian ini bertujuan untuk mengetahui peran ayah dan ibu dalam memberikan pendidikan seks sebagai upaya preventif mencegah terjadinya kejahatan seksual. Metode penelitian ini menggunakan studi literasi. Hasil dari penelitian ini menunjukkan bahwa peran ayah dan ibu dalam mencegah kejahatan seksual dapat dibedakan menjadi dua garis besar. Pertama berperan dalam membangun perasaan anak, kedua berperan dalam memberi keterampilan pada anak ketika menghadapi bahaya. Ketika anak telah mendapatkan dua peran ini dari ayah dan ibu, ia akan mampu merasakan bahwa dirinya berharga dan mampu menghindar dari tindak kejahatan seksual.Â Keywords: sexual abuse, father roles, mother roles
Inovasi Pembelajaran pada Pendidikan Anak Usia Dini dI Masa Pandemi Covid 19
Authors: Shofa Mila Faila 
Published: August 2022

Pandemi covid 19 yang terjadi saat ini mempunyai dampak dalam berbagai bidang baik ekonomi, kesehatan, social, keamanan termasuk pendidikan. Dampak pada bidang pendidikan yakni diterapkan pembelajaran jarak jauh dengan media online. Hal ini menuntut guru untuk berfikir kreatif dan inovatif dalam penentuan system pembelajaran yang dilakukan. Tujuan penelitian ini adalah untuk mendeskripsikan inovasi-inovasi pembelajaran pada masa pandemi covid 19 di PAUD Inklusi Saymara Kartasura. Metode penelitian yang digunakan adalah deskriptif kualitatif dengan tempat penelitian di PAUD Inklusi Saymara Kartasura, Sukoharjo, Jawa Tengah. Pengumpulan data menggunakan teknik observasi, wawancara dan dokumentasi tentang implementasi inovasi-inovasi pembelajaran selama pandemi covid 19, dimana pemeriksaan keabsahan data menggunakan teknik triangulasi sumber. Hasil penelitian ini menjelaskan bahwa Inovasi-inovasi pembelajaran di PAUD Inklusi Saymara ini dilakukan dengan tujuan untuk tetap menjaga kualitas pembelajaran dan perkembangan peserta didik. Inovasi-inovasi yang dilakukan yakni 1) Inovasi Perencanaan Pembelajaran, 2) Pembelajaran daring via Whatsapp Grup, 3) Pembelajaran daring via Google Classroom atau google kelas,Â 4) Home visit,Â 5) Pembelajaran luring dengan system rolling, 6) Evaluasi Perkembangan anak via google form.Â Keywords: Learning innovation, early childhood education, covid pandemic 19
Implementasi Perilaku Hidup Bersih dan Sehat Melalui Metode Pembiasaan di Masa Pandemi Covid-19 pada Anak Usia Dini
Authors: Hutami Meyda setyana 
Published: August 2022

Covid-19 is a disease that is spreading very quickly right now. The disease not only attacks adults but can also occur in children. Strategies that can be used for PHBS programs are to wash your hands with soap and running water, use masks, and keep your distance. The method used in this study is a descriptive cauldron with data collection techniques through observation, interview, and documentation.Â Based on the research concluded that children are very enthusiastic about the phbs program by getting used to hand washing with soap, using masks, and keeping distance from the crowd.
Deteksi Spasial Pada Model Indeks Ketimpangan Gender Indonesia
Authors: Marsono M 
Published: August 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh persentase penduduk perempuan umur 10 tahun ke atas yangtidak/belum pernah sekolah, persentase rumah tangga dengan kepala rumah tangganya perempuan, persentase perempuan umur 20-24 tahun berstatus kawin/hidup bersama sebelum umur 18 tahun, persentase persalinan tidak di fasilitas kesehatan, Indeks Pembangunan Manusia (IPM) pada penduduk perempuan, Indeks Pembangunan Gender (IPG), dan Indeks Pemberdayaan Gender (IDG) terhadap Indeks Ketimpangan Gender (IKG). Metode analisis menggunakan analisis regresi, yang didahului dengan deteksi spasial melalui uji ketergantungan wilayah (spatial dependency) dan keragaman wilayah (spatial heterogeneity) dengan menggunakan bobot spasial dengan pendekatan rook contiguity. Berdasarkan hasil analisis regresi linier diperoleh faktor-faktor yang signifikan mempengaruhi Indeks Ketimpangan Gender adalah persentase penduduk perempuan 10 tahun ke atas yang tidak/belum pernah sekolah, persentase perempuan umur 20-24 tahun berstatus kawin/hidup bersama sebelum umur 18 tahun, persentase persalinan tidak di fasilitas kesehatan, IPM pada penduduk perempuan, dan IDG. Sedangkan faktor yang tidak mempengaruhi IKG adalah persentase rumah tangga yang kepala rumah tangganya perempuan dan IPG. Dari hasil penelitian ini diharapkan dapat dimanfaatkan oleh pemerintah dalam mengambil langkah-langkah kebijakan untuk menurunkan ketimpangan gender di Indonesia.Â Keyword: IKG; Regresi; Spatial dependency; Spatial Heterogeinity
Mathematical Method to Construct the Linear Programming of Football Training
Authors: Liu Gang 
Published: August 2022

Abstract
This article uses mathematical modeling methods to predict the trajectory of a free kick in football. The article calculates the parameters of the ball’s trajectory and quantifies the power of direct free kick shots. The article combines Kalman filter prediction and linear interpolation to supplement the position of the missed ball in the video. The experimental results show that the estimated result of this method is highly similar to the actual flight trajectory of football. This algorithm can be applied in practice.
Stiffness Calculation of Gear Hydraulic System Based on the Modeling of Nonlinear Dynamics Differential Equations in the Progressive Method
Authors: Cui Fuyi , Wang Yingxian 
Published: August 2022

Abstract
The paper calculates the nonlinear dynamic differential equation model based on the stiffness of the gear teeth and gives the calculation method of the spring stiffness of the transmission system. Choose the Lyapunov energy function and derive the adaptive law that can make the system asymptotically stable globally. At the same time, we discussed the influence of the phase combination of the coupling shaft’s torsional stiffness and the gears’ meshing stiffness in the multi-stage gear transmission system on the system dynamics. The example calculation shows that the asymptotic method has higher solution accuracy and higher calculation efficiency. This algorithm is a highly versatile analytical solution method.
Relationship Between Enterprise Talent Management and Performance Based on the Structural Equation Model Method
Authors: Liu E , Liu Qing , Udimal Thomas Bilaliib , Zhu Haiou , Yousif Mohammed 
Published: August 2022

Abstract
This article uses SPSS19.0 and AMOS21.0 statistical software to explore the relationship between corporate talent management and corporate performance. We use the structural equation model to quantitatively analyze the human resource management factors that affect logistics performance. Research shows that intellectual capital has a significant positive effect on enterprise innovation performance. The value proposition of employee training to customers and good customer service have an overall positive economic effect. Human capital plays a significant role in driving innovation performance only in the more mature stage of enterprise development.