bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linear Growth Trajectories, Catch-up Growth, and Its Predictors Among North Indian Small-for-Gestational Age Low Birthweight Infants: A Secondary Data Analysis
Authors: Sinha Bireshwar , Choudhary Tarun Shankar , Nitika Nitika , Kumar Mohan , Mazumder Sarmila , Taneja Sunita , Bhandari Nita 
Published: May 2022

BackgroundLow birthweight small-for-gestational-age (SGA-LBW) (birthweight below the 10th percentile for gestational age; SGA-LBW) infants are at an increased risk of poor postnatal growth outcomes. Linear growth trajectories of SGA-LBW infants are less studied in South Asian settings including India.ObjectivesTo describe the linear growth trajectories of the SGA-LBW infants compared with appropriate-for-gestational-age LBW (AGA-LBW) infants during the first 6 months of life. In addition, we estimated catch-up growth (ΔLAZ &gt; 0.67) in SGA-LBW infants and their performance against the WHO linear growth velocity cut-offs. Additionally, we studied factors associated with poor catch-up growth in SGA-LBW infants.MethodsThe data utilized came from an individually randomized controlled trial that included low birthweight (LBW) infants weighing 1,500–2,250 g at birth. A total of 8,360 LBW infants were included. For comparison between SGA-LBW and AGA-LBW infants, we presented unadjusted and adjusted estimates for mean differences (MDs) or risk ratios (RRs) for the outcomes of length, linear growth velocity, length for age z-score (LAZ) score, and stunting. We estimated the proportion of catch-up growth. Generalized linear models of the Poisson family with log links were used to identify factors associated with poor catch-up growth in SGA-LBW infants.ResultsLow birthweight small-for-gestational-age infants had a higher risk of stunting, lower attained length, and a lower LAZ score throughout the first 6 months of life compared with AGA-LBW infants, with differences being maximum at 28 days and minimum at 6 months of age. The linear growth velocity in SGA-LBW infants compared with AGA-LBW infants was significantly lower during the birth–28 day period [MD −0.19, 95% confidence interval (CI): −0.28 to −0.10] and higher during the 3- to 6-month period (MD 0.17, 95% CI: 0.06–0.28). Among the SGA-LBW infants, 55% showed catch-up growth for length at 6 months of age. Lower wealth quintiles, high birth order, home birth, male child, term delivery, non-exclusive breastfeeding, and pneumonia were associated with the higher risk of poor catch-up in linear growth among SGA-LBW infants.ConclusionSmall for gestational age (SGA) status at birth, independent of gestational age, is a determinant of poor postnatal linear growth. Promotion of institutional deliveries, exclusive breastfeeding, and prevention and early treatment of pneumonia may be helpful to improve linear growth in SGA-LBW infants during early infancy.Clinical Trial Registration[https://clinicaltrials.gov/], identifier [NCT02653534].
Contrast-Enhanced Cone-Beam Breast CT: An Analysis of Diagnostic Value in Predicting Breast Lesion With Rim Enhancement Malignancy
Authors: Zhao Xin , Yang Jun , Zuo Yang , Kang Wei , Liao Hai , Zheng Zhong-Tao , Su Dan-Ke 
Published: May 2022

BackgroundThe objective of the current study was to investigate the diagnostic value of contrast-enhanced cone-beam breast computed tomography (CE-CBBCT) for breast lesion with rim enhancement (RE).MethodsAll 36 patients were examined by non-contrast (NC-CBBCT) and contrast-enhanced CBBCT (CE-CBBCT) after contrast media (CM) injection. Qualitative morphological enhancement parameters and quantitative enhancement parameters were compared between malignant and benign groups. Multivariable logistic regression analysis was performed to identify independent factors that could predict breast lesion with RE malignancy. Receiver operating curve (ROC) was used to evaluate prediction performance.ResultsA total of 36 patients with 40 lesions underwent breast CE-CBBCT were enrolled. There were significant differences in most qualitative morphological enhancement parameters between the two groups. A multivariate logistic regression model showed that △standardized HU (INRphase 2−INRpreCM) [odds ratio (OR) = 1.148, 95% CI = 1.034–1.276, p = 0.01] and △standardized HU (RPphase 2 − RPphase 1) (OR = 0.891, 95% CI = 0.814–0.976, p = 0.013) were independent indicators in predicting breast lesion with RE malignancy. △standardized HU (INRphase 2 − INRpreCM) combined with △standardized HU (RPphase 2 − RPphase 1) showed significant larger area under the receiver operating curve (AUC) and higher sensitivity than each alone (p &lt; 0.001, AUC = 0.932, sensitivity = 92.59%, specificity = 92.31%). The regression equation of the prediction model was as follows: Logit (p) = 0.351 + 0.138X × △standardized HU (INRphase 2 − INRpreCM) − 0.115 × △standardized HU (RPphase 2 − RPphase 1).ConclusionWith the observation of qualitative morphological enhancement parameters and the comparison of quantitative enhancement parameters of CBBCT, a reliable basis for the diagnostic accuracy in predicting breast lesion with RE could be provided. These conclusions should be verified in large, well-designed studies.
Case Report: Long-Term Treatment and Follow-Up of Kleefstra Syndrome-2
Authors: Wu Dandan , Li Rong 
Published: May 2022

BackgroundMutations in the KMT2C gene can cause Kleefstra syndrome-2 (KLEFS2).CaseIn this study, we analyzed the clinical, genetic testing, and 10-year follow-up data of a child with KLEFS2 treated at the Child Healthcare Department, Children's Hospital of Nanjing Medical University, Nanjing. The case of KLEFS2 presented feeding difficulty and developmental delay, both intervened by nutritional support and family rehabilitation. Obvious attention deficit hyperactivity disorder (ADHD) occurred in preschool and school-age children and was managed by behavioral and pharmaceutical interventions.ConclusionFeatures of KLEFS2 include feeding difficulty and developmental delays in an early age, as well as ADHD in preschool and school age. Satisfactory outcomes are not achieved in early nutritional support for correcting malnutrition and pharmaceutical intervention for relieving ADHD, but both measures can counter developmental delay.
Pathogenicity and Long-Term Outcomes of Liddle Syndrome Caused by a Nonsense Mutation of SCNN1G in a Chinese Family
Authors: Zhang Di , Qu Yi , Dong Xue-Qi , Lu Yi-Ting , Yang Kun-Qi , Liu Xin-Chang , Fan Peng , Hu Yu-Xiao , Yang Chun-Xue , Gao Ling-Gen , Liu Ya-Xin , Zhou Xian-Liang 
Published: May 2022

ObjectiveLiddle syndrome (LS) is a monogenic hypertension consistent with autosomal dominant inheritance, often with early onset high blood pressure in childhood or adolescence. This study aimed to identify the pathogenicity of a nonsense mutation in SCNN1G in a Chinese family with LS and the long-term outcomes of tailored treatment with amiloride.MethodsTo explore the pathogenicity of candidate variant reported in 2015 by our team, we constructed mutant and wild-type models in vitro and measured amiloride-sensitive current in Chinese Hamster Ovary (CHO) cells using patch clamp technique. Participants were followed up for 7 years after tailored treatment with amiloride.ResultsA nonsense variant was detected in six members, two of whom were pediatric patients. This mutation resulted in a termination codon at codon 572, truncating the Pro-Pro-Pro-X-Tyr motif. The mutant epithelial sodium channels displayed higher amiloride-sensitive currents than the wild-type channels (P &lt; 0.05). Tailored treatment with amiloride achieved ideal blood pressure control in all patients with normal cardiorenal function, and no adverse events occurred during follow-up.ConclusionWe found the pathogenicity of a nonsense SCNN1G mutation (p.Glu571*) with enhanced amiloride-sensitive currents in a LS family with young patients. Tailored treatment with amiloride may be an effective strategy for the long-term control of blood pressure and protection from target organ damage or cardiovascular events, including children and youth patients with LS.
Neuromuscular Blockade for Cardiac Arrest Patients Treated With Targeted Temperature Management: A Systematic Review and Meta-Analysis
Authors: Lin Tong , Yao Yan , Xu Yuan , Huang Hui-Bin 
Published: May 2022

Background: Neuromuscular-blocking agents (NMBA) are often administered to control shivering in comatose cardiac arrest (CA) survivors during targeted temperature management (TTM) management. Thus, we performed a systematic review and meta-analysis to investigate the effectiveness and safety of NMBA in such a patient population.Methods: We searched for relevant studies in PubMed, Embase, and the Cochrane Library until 15 Jul 2021. Studies were included if they reported data on any of the predefined outcomes in adult comatose CA survivors managed with any NMBA regimens. The primary outcomes were mortality and neurological outcome. Results were expressed as odds ratio (OR) or mean difference (MD) with an accompanying 95% confidence interval (CI). Heterogeneity, sensitivity analysis, and publication bias were also investigated to test the robustness of the primary outcome.Data Synthesis: We included 12 studies (3 randomized controlled trials and nine observational studies) enrolling 11,317 patients. These studies used NMBA in three strategies: prophylactic NMBA, bolus NMBA if demanded, or managed without NMBA. Pooled analysis showed that CA survivors with prophylactic NMBA significantly improved both outcomes of mortality (OR 0.74; 95% CI 0.64–0.86; I2 = 41%; p &lt; 0.0001) and neurological outcome (OR 0.53; 95% CI 0.37–0.78; I2 = 59%; p = 0.001) than those managed without NMBA. These results were confirmed by the sensitivity analyses and subgroup analyses. Only a few studies compared CA survivors receiving continuous versus bolus NMBA if demanded strategies and the pooled results showed no benefit in the primary outcomes between the two groups.Conclusion: Our results showed that using prophylactic NMBA strategy compared to the absence of NMBA was associated with improved mortality and neurologic outcome in CA patients undergoing TTM. However, more high-quality randomized controlled trials are needed to confirm our results.
Importancia del liderazgo directivo en la gestión del estrés ocupacional en un gobierno local
Authors: Abad Alvarez Sandy Yuvicsa , Camacuari Callupe Yanina Donata , De La Cruz Vargas Alexander David 
Published: May 2022

El manejo del estrés ocupacional es un problema que afecta a las organizaciones, porque influye sobre el desempeño de los trabajadores, afectando el clima y decayendo la productividad, de ahí que se necesite la figura del líder que pueda mejor la situación problemática e influya positivamente sobre el clima organizacional. De esta manera, la investigación se desarrolla en la descripción de cómo el liderazgo directivo resulta importante e influye en la gestión del estrés ocupacional en los trabajadores de la Municipalidad Distrital Cristo Nos Valga – Piura. La realización de investigación descriptiva parte de uso de la metodología cuantitativa y cualitativa, de corte transversal, haciendo uso de la técnica de encuesta. Además, la población y muestra está conformada por 112 trabajadores administrativos. Finalmente, los resultados mostraron que existe una relación directamente proporcional entre el liderazgo directivo y el estrés ocupacional de los trabajadores de la Municipalidad Cristo Nos Valga de Piura.
Comunidades de práctica, pasos para su implementación
Authors: Mendoza Yépez Yolanda Alexandra , Torres María Francisca , Sarmiento Germania 
Published: May 2022

Las comunidades de práctica han sido reconocidas como un activo intangible muy valioso dentro de la gestión empresarial, de ahí que las mejores organizaciones del mundo están destinando tiempo y recursos al diseño, implantación y mantenimiento de estas. Las Comunidades de Práctica son redes sociales dinámicas y flexibles. El objetivo fue analizar los hallazgos en cuanto al proceso que debe cumplir una comunidad práctica. El diseño se basó en la búsqueda de bibliografía de diversos autores como fuentes para la descripción de los puntos desarrollados sobre las comunidades de prácticas y gestión del conocimiento. De esta manera, las comunidades de práctica se convierten en un concepto clave como unidad básica de análisis, especialmente en las empresas que requieren y poseen gran cantidad de conocimiento.
Gestión para la simplificación administrativa en trámites académicos en la Universidad Nacional Toribio Rodríguez de Mendoza
Authors: Rojas Paico Jessica Noemí 
Published: May 2022

La simplificación administrativa en los trámites académicos es un reto que asume la universidad nacional Toribio Rodríguez de Mendoza, en eliminar obstáculos o costos innecesarios para la comunidad universitaria que generan el inadecuado funcionamiento de la administración pública; relacionado a la calidad de atención. Es por ello, que el propósito del estudio fue diagnosticar el proceso de simplificación administrativa en los trámites académicos de la Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas. Para ello se basó en la metodología de tipo básica descriptiva de enfoque cuantitativa, con un diseño no experimental de corte transversal, asimismo se usó una muestra con un muestreo probabilístico simple con una unidad de análisis de 349 estudiantes. Se aplicó la técnica de la encuesta, con el instrumento del cuestionario. Obteniendo un resultado de valoración de 36,1% de nivel baja, 34,4% de nivel media y por último de 29,5% de nivel alta. Por lo tanto, se concluye que existe una simplificación administrativa con tiempos de atención significando que la atención, los trámites y los procedimientos administrativos que se utilizan no han logrado satisfacer a los usuarios.
Simplificación administrativa para la satisfacción del usuario de la municipalidad
Authors: Villanueva Coico Guillermo Ricardo , Perez Astonitas Nelba , Flores Carrero Juan Rubén 
Published: May 2022

La satisfacción del usuario es un indicador de calidad de atención prestada en las instituciones públicas, en la cual esta permite mejorar todas las falencias y reafirmar fortalezas; sin embargo, la Municipalidad distrital de Jayanca ha sido cuestionada en varias ocasiones y la mayoría de las veces los usuarios se encuentran insatisfechos con el servicio brindado, debido a una deficiente gestión en la planificación de estrategias que contrarresten dicha satisfacción. El propósito fue diagnosticar el estado actual de la satisfacción del usuario de la municipalidad distrital de Jayanca. Este estudio fue de tipo básica y un diseño descriptivo no experimental con un enfoque cuantitativo; asimismo, se usó una muestra de 337 usuarios empleando un muestreo probabilístico aleatorio simple. Obteniendo un resultado que el 50% de usuarios respondieron nunca toman medidas correctivas para mejorar la simplificación administrativa, el 29% manifestaron que casi nunca, el 10% a veces, el 7% siempre y por último el 4% casi siempre. En la cual se concluye, que los usuarios tienen una percepción de que la administración nunca toma medidas correctivas para mejorar la simplificación administrativa. Por lo tanto, urge diseñar un modelo de simplificación administrativa para mejorar la calidad de atención.
Uso de plataforma Microsoft teams y satisfacción académica en el posgrado de la Universidad Nacional Federico Villarreal
Authors: Saavedra López Juan José , Garvich Ormeño Angie Marlene , Zorrilla Díaz José Eduardo 
Published: May 2022

La pandemia ocasionó una serie de problemas y muchos desafíos para todos los sectores productivos del Perú, especialmente en el ámbito educativo, donde para garantizar la continuidad de la educación se migró a la virtualidad en muy poco tiempo. La presente investigación tuvo como propósito relacionar el uso de la plataforma TEAMS con la satisfacción académica del estudiante de postgrado de la Universidad Nacional Federico Villarreal. Fue una investigación descriptiva correlacional de diseño no experimental y de corte trasversal aplicado a una muestra de 110 estudiantes. Para la recolección de datos, se usaron 2 cuestionarios que cuentan con validez de constructo y confiabilidad Alfa de Cronbach del 0,852 y 0,866 respectivamente. Los resultados señalaron que sí existe una correlación significativa entre ambas variables, lo que se ve reflejado en el Coeficiente de correlación de Spearman de 0.795. Se concluyó que el uso efectivo de la plataforma TEAMS garantiza la satisfacción académica del estudiante de posgrado.
PENINGKATAN PENGETAHUAN ANAK SEKOLAH DASAR TENTANG PHBS MELALUI MEDIA ULAR TANGGA YANG DIMODIFIKASI
Authors: Fithri Asep , Karjatin Atin , Lestari Febri Sri 
Published: May 2022

Perilaku Hidup Bersih dan Sehat (PHBS) bisa menjadi pondasi dari perilaku sehat bagi siswa, guru dan masyarakat dilingkungan sekolah. Sehingga upaya memberdayakan siswa, guru, dan masyarakat lingkungan sekolah agar berperan aktif mewujudkan sekolah sehat melalui PHBS menjadi salah satu strategi yang tepat untuk meningkatkan derajat kesehatan masyarakat.
Penggunaan berbagai metode dan media promosi kesehatan yang beragam diyakini dapat membantu meningkatkan pengetahuan siswa akan PHBS di sekolah, salah satunya adalah permainan ular tangga yang dimodifikasi dengan penambahan kartu PHBS. Media promosi kesehatan ini diharapkan memiliki pengaruh yang signifikan dalam meningkatkan perilaku hidup bersih dan sehat melalui pengetahuan, sikap dan tindakan. Tujuan penelitian ini adalah untuk mengetahui perbedaan skor nilai pengetahuan, sikap, tindakan dan perilaku sebelum dan sesudah siswa bermain game ular tangga yang dimodifikasi di SD Negeri Cibeureum I Kabupaten Bandung. Penelitian ini menggunakan desain quasy eksperiment dengan desain one group pretest-posttest design pada 21 orang siswa SD Negeri Cibeureum I Kabupaten Bandung. Penelitian ini menggunakan alat ukur kuesioner dan lembar observasi. Analisis data menggunakan univariat dan bivariat dengan uji paired sample t-test pada α 0.05.
Hasil analisis data menunjukkan Penggunaan media promosi kesehatan “Ular Tangga Yang Dimodifikasi” secara signifikans dapat meningkatkan Pengetahuan Dan Perilaku Hidup Bersih Dan Sehat Di Sekolah Dasar Negeri Cibeureum I Kabupaten Bandung.
Glomerular filtration rate in centenarians with coronary artery disease
Authors: Тополянская С.В. , Елисеева Т.А. , Санина А.И. , Вакуленко О.Н. , Дворецкий Л.И. 
Published: May 2022

Цель исследования - сравнение методов расчета по формулам CKD-EPI, MDRD, BIS1 и Кокрофта-Голта для расчета СКФ, а также анализ различных взаимосвязей СКФ и клинических и лабораторных параметров у долгожителей с ИБС. Данная работа - одномоментное (поперечное) исследование, в которое были включены 270 пациентов 90-106 лет, госпитализированных с диагнозом ИБС. Средняя СКФ по формуле CKD-EPI составила 51,4±14,2 мл/мин, MDRD - 50,9±13,4, BIS1 - 38,4±7,7, Кокрофта-Голта - 40,6±12,6. Лишь у 75 (27,8 %) пациентов СКФ была ≥60 мл/мин. Чаще всего регистрировали IIIА стадию ХБП, тогда как V стадию не наблюдали ни у одного больного. Результаты определения стадии ХБП, рассчитанные с использованием формул MDRD и CKD-EPI, были аналогичными. Однако при использовании формулы BIS1, СКФ >60 мл/мин не зарегистрировали ни у одного пациента, а подавляющее большинство больных (64,1 %) имели ХБП IIIБ стадии. При высоком уровне креатинина не было значительных различий между показателями СКФ, рассчитанными с помощью разных формул, в то время как при низких и средних значениях креатинина наблюдали существенные различия в СКФ, оцененной с помощью формул CKD-EPI и MDRD, с одной стороны, и BIS1 и Кокрофта-Голта - с другой. Максимальные различия достигали 21 мл/мин.
The study objective was to compare the CKD-EPI, MDRD, BIS1, and Cockroft-Gault equations for calculating GFR, and analyze the various relationships between the glomerular filtration rate and clinical and laboratory parameters in long-living patients with coronary artery disease (CAD). A cross-sectional study of 270 patients from 90 to 106 years old, hospitalized with CAD diagnosis, was performed. The mean estimated GFR according to CKD-EPI was 51,4±14,2 ml/min, MDRD - 50,9±13,4, BIS1 - 38,4±7,7, Cockroft-Gault - 40,6±12,6 ml/min. Only 75 patients (27,8 %) had CKD-EPI eGFR greater than or equal to 60 ml/min. The most common stage of chronic kidney disease was stage 3A, while stage CKD 5 did not occur at all. CKD staging results calculated using the MDRD and CKD-EPI equations were similar. However, when using the BIS1 equation, eGFR of more than 60 ml/min was not observed in any patient, and the vast majority of patients (64,1 %) had stage 3B CKD. At high creatinine levels, there were no considerable differences between eGFR according to different equations, while at low and medium creatinine values, there were significant differences in eGFR, assessed using the CKD-EPI and MDRD equations on the one hand and BIS1 and Cockroft-Gault on the other. The maximum differences reached 21 ml/min.
Socio-cognitive correlates of life satisfaction of students of the National University aged 55-80 years
Authors: Долгова В.И. , Рокицкая Ю.А. 
Published: May 2022

Достижение удовлетворенности жизнью в условиях сложной эпидемиологической ситуации, детерминирующей хронический стресс, затянувшийся режим социально-экономических ограничений и самоизоляции, повышенную смертность, представляется актуальной и, вместе с тем, трудно разрешимой задачей. Поэтому понимание социально-когнитивных коррелятов жизненной удовлетворенности после 55 лет позволяет моделировать её ментальные конструкции, имеющие стресс-протекторное свойство, с последующей возможностью их психологической коррекции. Цель исследования - теоретически обосновать, выявить и обсудить результаты анализа корреляции социально-когнитивных особенностей и жизненной удовлетворённости после 55 лет. Гипотеза исследования базируется на предположении о взаимосвязи исследуемых показателей. Теоретический анализ феноменологии удовлетворённости жизнью выявил социально-когнитивную природу и эмоциональную, отражательно-оценочную индикацию её возникновения, функционирования и динамики. Применяли следующие психодиагностические методики: опросник «Ваше самочувствие» (авторы - О.С. Копина, Е.А. Суслова, Е.В. Заикин), методику диагностики наличия и выраженности иррациональных установок (А. Эллис), методику диагностики социально-психологических особенностей (Т. Лири). Выборочную совокупность составили 80 человек 55-80 лет. Корреляционный анализ выявил взаимообусловленность показателей жизненной удовлетворённости и социально-когнитивных характеристик личности в пожилом возрасте.
Achieving life satisfaction in a complex epidemiological situation that determines chronic stress, a prolonged regime of socio-economic restrictions and self-isolation, increased mortality, seems to be an urgent and at the same time difficult to solve task. Therefore, understanding the socio-cognitive correlates of life satisfaction after 55 years allows us to model its mental constructions that have a stress-protective property, with the subsequent possibility of their psychological correction. The purpose of the study is to theoretically substantiate, identify and discuss the results of the correlation analysis of the relationship between socio-cognitive characteristics and life satisfaction after 55 years. The hypothesis of the study is based on the assumption of the relationship between the studied indicators. Theoretical analysis of the phenomenology of life satisfaction (life satisfaction) revealed the socio-cognitive nature and emotional, reflective and evaluative indication of its occurrence, functioning and dynamics. Psychodiagnostic methods were used: the questionnaire «Your well-being» (O.S. Kopina, E.A. Suslova, E.V. Zaikin), methods for diagnosing the presence and severity of irrational attitudes (A. Ellis), methods for diagnosing socio-psychological characteristics (T. Leary). The sample consisted of people aged 56-80 years in the number of 80 people. Correlation analysis revealed the conditionality of indicators of life satisfaction and socio-cognitive characteristics of a person in old age.