bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions for children with deafblindness—An integrative review
Authors: Sundqvist Ann‐Sofie , Wahlqvist Moa , Anderzén‐Carlsson Agneta , Olsson Emma 
Published: September 2022

AbstractBackgroundDeafblindness is a rare condition, and its prevalence has been reported to be approximately 1 in 27 000 new‐borns worldwide. For individuals with deafblindness, lifelong interventions and support are needed to be able to develop communication, be active and preserve a good quality of life. Because little is known about what kind of support and interventions can be offered to children with deafblindness, the aim was to summarize and disseminate research findings regarding this topic.MethodsIntegrative review principles were employed. Systematic searches in eight databases and additional manual searches were conducted. The inclusion criteria were as follows: original studies published between 2000 and 2021 examining either interventions for children between 0 and 18 years of age with deafblindness or interventions aimed at children with deafblindness but offered to their relatives or professionals working with them. Studies on support for family members were also sought. Study characteristics were described, and key findings were synthesized into categories based on their similarities.ResultsOf the 6268 identified original studies, 32 were included. The key outcomes from the included studies were synthesized into three categories, with two categories illustrating the goal/intention of the intervention (social interaction and communication, motivation and participation) and one focusing on or identifying the action taken to benefit the child (adaptation of the educational environment). Social interaction and communication was the dominant category, covering 24 of the 32 included studies.ConclusionsThis review concludes that there are a limited number of evaluated interventions for children with deafblindness. In many cases, the interventions were adapted to the individual child's needs, and most of them were found within the area of social interaction and communication. More research is needed to strengthen the level of evidence for interventions for children with deafblindness.
Effect of semantics in the study of tolerance for wolves
Authors: Carlson Shelby C. , Dietsch Alia M. , Slagle Kristina M. , Bruskotter Jeremy T. 
Published: September 2022

AbstractAs conservation scholars increasingly recognize the critical role of human thought and behavior in determining the persistence of biodiversity across the globe, a growing line of inquiry regarding the validity and comparability of previous applications of core psychological concepts has emerged. Specifically, inconsistent measurement and use of terms, such as attitudes and acceptance, reveal important questions about previous approaches. Given that these concepts differ by definition, yet have been used interchangeably, we explored what drives differences in people's responses when each concept is operationalized in the context of a contested wildlife species, the gray wolf (Canis lupus). To do so, we used data from a 2014 survey of U.S. residents (n = 1287) to test how measures of six concepts (i.e., acceptance, attitudes, benefits, risks, [prior] behavior, and behavioral intentions) often employed in the conservation social sciences were related with a broad set of possible explanatory variables. Despite moderate to strong correlations between all concepts measured (| Pearson's r | = 0.39–0.65, p < 0.001), results revealed considerable variation in their respective relationships with identical explanatory variables. Specifically, although wildlife value orientation (i.e., domination or mutualism) operated fairly consistently across cognitive and behavioral concepts, the relationship between the six concepts and other factors, such as social trust, identification with various interest groups (i.e., hunter, farmer, or rancher, environmentalist, and animal rights advocate), and political ideology (i.e., liberal vs. conservative), varied considerably. Our findings underscore that differences exist in these measures, which could have serious implications for conservationists integrating social science findings in their decision‐making processes if they are unaware of the theoretical underpinnings of and distinctions between core psychological concepts.
Learning curve for peroral endoscopic myotomy in therapeutic endoscopy experts and nonexperts: Large single‐center experience
Authors: Fujiyoshi Yusuke , Inoue Haruhiro , Fujiyoshi Mary Raina Angeli , Rodriguez de Santiago Enrique , Nishikawa Yohei , Toshimori Akiko , Tanabe Mayo , Shimamura Yuto , Sumi Kazuya , Ono Masashi , Shiwaku Hironari , Ikeda Haruo , Onimaru Manabu 
Published: September 2022

ObjectivesReports on learning curve for peroral endoscopic myotomy (POEM) in therapeutic endoscopy nonexperts are limited. We aimed to assess the number of cases required to achieve POEM proficiency for endoscopic submucosal dissection (ESD) experts and nonexperts.MethodsThis is a retrospective study at the largest POEM referral center in Japan. POEM between April 2014 and December 2020 were included. Nonexperts and ESD experts were divided by training phases: A, 1–20; B, 21–40; C, 41–60; D, 61–80; and E, 81–100 cases. Primary outcome was operation time, and the phase to reach target time (83 min) was investigated. Secondary outcomes were clinical success rate, adverse events, and post‐POEM gastroesophageal reflux disease (GERD).ResultsFive hundred and sixty‐six cases were performed by 14 nonexperts, and 555 cases by 15 ESD experts. As the primary outcome, operation time in nonexperts was: A, 95 (79–115.8); B, 86.5 (71–105); C, 80 (70–100); D, 73 (64.5–100.5); and E, 73.5 (57.8–88.8) min, while in ESD experts: A, 90 (74–128); B, 77 (70–92); and C, 77 (70–93.5) min (median [interquartile range]). Operation time decreased significantly as experience increased in both groups (P < 0.001), and nonexperts required 41–60 cases to achieve proficiency, while experts required 21–40 cases. As secondary outcomes, in nonexperts, clinical success was 96.9–100%, adverse events were 5.0–9.2%, symptomatic GERD was 11.8–26.5%, and proton pump inhibitor (PPI) intake was 11.5–18.7% in each phase. While in experts, clinical success was 96.2–100%, adverse events were 3.0–5.8%, symptomatic GERD was 14.6–22.0%, and PPI intake was 12.6–17.9%. There were no significant differences among training phases.ConclusionsNon‐ESD experts require more cases to achieve proficiency in POEM. These results are useful for establishing POEM training programs and institutional implementation of the procedure.
Fichte and Hegel on free time
Authors: Heisenberg Thimo 
Published: September 2022

AbstractTo us today, it seems intuitive that an ideal society would secure for its citizens some time for leisure that is, some time to do “whatever they want” after having attended to their various responsibilities and natural needs. But, in this essay, I argue that—in 19th century social philosophy—the status of leisure (Muße) in an ideal society was actually surprisingly controversial: whereas J.G. Fichte makes a strong case for leisure as part of an ideal society (going even so far as considering it its central good), G.W.F. Hegel implicitly argues against this idea. For him, leisure is a crook that we only need as long as the social conditions are not sufficiently ideal—whereas a truly rational society would create a new type of work that subsumes the benefits of leisure into work itself. In this essay, I reconstruct this largely forgotten disagreement and argue that although both positions contain an important overstatement, each includes an important lesson for the contemporary debate on leisure and society.
Pregnancy outcomes after early fetal exposure to injectable first‐line treatments, dimethyl fumarate, or natalizumab in Danish women with multiple sclerosis
Authors: Andersen Johanna Balslev , Sellebjerg Finn , Magyari Melinda 
Published: September 2022

AbstractBackground and purposeData on pregnancy outcomes following fetal exposure to disease‐modifying drugs (DMDs) in women with multiple sclerosis (MS) are sparse although growing.MethodsData from the Danish Multiple Sclerosis Registry were linked with nationwide registries enabling an investigation of adverse pregnancy outcomes in newborns of women with MS following fetal exposure to injectable first‐line treatments, dimethyl fumarate, glatiramer acetate, or natalizumab. Logistic regression models accounting for clustered data were used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for individual and composite adverse outcomes after adjusting for relevant covariates.ResultsA total of 1009 DMD‐exposed pregnancies were compared with 1073 DMD‐unexposed pregnancies as well as 91,112 pregnancies from the general population. No association of an increased risk of any perinatal outcome was found when comparing newborns with fetal exposure with the general population, including preterm birth (OR = 1.19, 95% CI = 0.86–1.64), small for gestational age (OR = 1.38, 95% CI = 0.92–2.07), spontaneous abortion (OR = 1.04, 95% CI = 0.84–1.27), congenital malformation (OR = 0.99, 95% CI = 0.68–1.45), low Apgar score (OR = 0.62, 95% CI = 0.23–1.65), stillbirth (OR = 1.05, 95% CI = 0.33–3.31), placenta complication (OR = 0.53, 95% CI = 0.22–1.27), and any adverse event (OR = 1.10, 95% CI = 0.93–1.30). Similar results were found when comparing DMD‐exposed pregnancies with DMD‐unexposed pregnancies.ConclusionsWe found no increased association of adverse pregnancy outcomes in newborns with fetal exposure to DMDs when compared with either DMD‐unexposed pregnancies or the general population.
Maintenance of response and predictive factors of 1‐year GalcanezumAb treatment in real‐life migraine patients in Italy: The multicenter prospective cohort GARLIT study
Authors: Vernieri Fabrizio , Brunelli Nicoletta , Marcosano Marilena , Aurilia Cinzia , Egeo Gabriella , Lovati Carlo , Favoni Valentina , Perrotta Armando , Maestrini Ilaria , Rao Renata , d'Onofrio Luigi , Finocchi Cinzia , Aguggia Marco , Bono Francesco , Ranieri Angelo , Albanese Maria , Di Piero Vittorio , Cevoli Sabina , Altamura Claudia , Barbanti Piero ,   for the GARLIT Study Group
Published: September 2022

AbstractBackground and PurposeTo evaluate the 1‐year effectiveness and tolerability of galcanezumab in real life and the prognostic indicators of persistent response.MethodsHigh‐frequency episodic migraine (HFEM) and chronic migraine (CM) patients treated with galcanezumab who completed a 1‐year observation were enrolled. The primary outcomes assessed during the 12 months (V1–V12) were the change in monthly migraine days (MMDs) from baseline and the response rates ≥50% in MMDs (MMD ≥50% RR). The secondary outcomes were changes in pain intensity (numerical rating scale [NRS]) and in monthly acute medication intake (MAMI).ResultsWe enrolled 191 patients (77.5% CM). Twenty‐three patients (12%) dropped out, two for nonserious adverse events. At least 40% of patients took add‐on standard preventives from baseline to V12. At V12, MMDs were reduced by 6.0 days in HFEM and by 11.9 days in CM patients (both p < 0.00001); NRS and MAMI were also decreased in both groups (p < 0.00001). One‐hundred eight (56.5%) patients presented MMD ≥50% RR for 9 cumulative months (interquartile range=8): we defined this value as the cutoff for a persistent response. Persistent responders were less likely to have a higher body mass index (BMI) (p = 0.007) but more frequently had a good response to triptans (p = 0.005) and MMD ≥50% RR at V1 (p < 0.0000001). Patients without a persistent response were on add‐on therapy for longer periods of time (p < 0.001).ConclusionsGalcanezumab was effective and well‐tolerated in the 1‐year term, with most patients presenting MMD ≥50% RR for at least 9 months. Triptan response, lower BMI, and MMD ≥50% RR in the first month emerged as predictive factors for a persistent response.
Antagonistic, synergistic, and additive antibacterial interaction between ciprofloxacin and amoxicillin against Staphylococcus aureus
Authors: Gómez‐Sánchez Eduardo , Franco‐de la Torre Lorenzo , Hernández‐Gómez Adriana , Alonso‐Castro Ángel Josabad , Serafín‐Higuera Nicolás , Terán‐Rosales Flavio , Bologna‐Molina Ronell Eduardo , Isiordia‐Espinoza Mario Alberto 
Published: September 2022

AbstractThe aim of this in vitro study was to evaluate the interaction between ciprofloxacin and amoxicillin against beta‐lactamase‐producing Staphylococcus aureus. Concentration‐dependent curves for each individual drug were carried out to obtain the mean inhibitory concentration in the agar well diffusion assay. Then, different ratios of the ciprofloxacin–amoxicillin combination (0.5:0.5, 0.8:0.2, 0.2:0.8, 0.9:0.1, 0.1:0.9, 0.95:0.05, and 0.05:0.95) were assessed. Data were analyzed using the isobolographic analysis and interaction index. The isobolographic evaluation shows that the 0.9:0.1 and 0.95:0.05 ratios of the ciprofloxacin–amoxicillin combination produced a synergistic antimicrobial interaction, the 0.8:0.2, 0.2:0.8, 0.1:0.9, and 0.05:0.95 proportions showed an additive antibacterial effect, and the 0.5:0.5 proportion induced antagonistic antimicrobial effects. The interaction index showed similar outcomes to the isobolographic analysis. In conclusion, the data of this study mainly show antimicrobial additive results of the ciprofloxacin–amoxicillin combination against beta‐lactamase‐producing S. aureus.
Thermal traits of freshwater macroinvertebrates vary with feeding group and phylogeny
Authors: Tomczyk Nathan J. , Rosemond Amy D. , Rogers Phoenix A. , Cummins Carolyn S. 
Published: September 2022

Abstract

Functional traits of organisms, especially feeding traits, influence how organisms mediate ecosystem processes. As climate change, landscape modification and industrial waste heat release continue to increase water temperatures, shifts in the composition of feeding traits within aquatic macroinvertebrate communities may alter ecosystem processes. However, it is unclear whether thermal traits of macroinvertebrates vary systematically across functional feeding groups (FFGs; i.e., categories based on feeding ecology such as herbivores, shredders, predators, etc.) or phylogeny.

We used previously published datasets on hundreds of macroinvertebrate taxa to evaluate how thermal traits differed across FFGs. We also examined the strength of phylogenetic signal in both FFG and thermal traits, using a new phylogeny of insect taxa. Then, we tested whether phylogenetic patterns offered a plausible explanation for differences in thermal traits among FFGs by comparing phylogenetic and non‐phylogenetic regressions.

Shredders tended to have lower temperature preferences, optima and maxima (three of five of the thermal traits evaluated) than other FFGs. Patterns for other FFGs differed by thermal trait, but predators, collector‐gatherers and filterers had some of the highest thermal trait values. FFG explained 40% of the variation in critical thermal maximum, but <12% of the variation in the four other thermal traits.

Phylogeny explained 26%–88% of the variation in thermal and feeding traits. For the subset of taxa and trait data that were available, phylogeny explained more than double the variation in thermal traits relative to FFG, but comparison of phylogenetic and non‐phylogenetic regressions highlighted that FFG explained variation in thermal traits that was independent of phylogeny.

Our results highlight phylogeny and FFG as predictors of thermal traits in aquatic macroinvertebrates. Our results suggest that warmer water temperatures could favour predators, filterers and collector‐gatherers over shredders. Furthermore, our results confirm that certain orders of macroinvertebrates, such as Diptera, may be better suited to warmer temperatures than other orders, such as Plecoptera.
Nutrient management and bioaugmentation interactively shape plant–microbe interactions inMiscanthus × giganteus
Authors: Kane Jennifer L. , Robinson Marshall C. , Schartiger Ronald G. , Freedman Zachary B. , McDonald Louis M. , Skousen Jeffrey G. , Morrissey Ember M. 
Published: September 2022

AbstractMarginal lands are an untapped source of agricultural potential, particularly regarding high‐yielding, low‐input bioenergy crops likeMiscanthus × giganteus(Miscanthus).Miscanthusis of specific interest because it can be productive and sequester carbon in soil even under the stressful conditions present on some degraded lands. A key component of these abilities is the interaction ofMiscanthuswith its soil and root microbiome. Microbial functions depend on the nutrient status of soil, and hence are sensitive to fertilization regimes. Nevertheless, little is known about how fertilization strategies affect the partnership ofMiscanthuswith its microbial associates. Here, we tested the individual and interactive effects of nutrient addition and bioaugmentation (i.e., the addition of microbial communities) onMiscanthusperformance and microbiome function in marginal soil. We found that the effect of nutrient addition onMiscanthusbiomass yield depended on nutrient addition type (i.e., organic or inorganic nutrients) and whether bioaugmentation was also applied. Some microbial functions, like free‐living nitrogen fixation and carbon use efficiency, were sensitive to nutrient addition depending on whether bioaugmentation was also applied. On the other hand, arbuscular mycorrhizal fungus colonization of roots decreased with fertilization regardless of bioaugmentation. These results imply that managing microbial communities may regulate the effect of nutrient addition on plant–microbe interactions that in part determine system productivity and environmental impact.
‘Language has been granted too much power’.1,p.1 Challenging the power of words with time and flexibility in the precommencement stage of research involving those with cognitive impairment
Authors: Locock Louise , O'Donnell Deirdre , Donnelly Sarah , Ellis Liz , Kroll Thilo , Shé Éidín Ní , Ryan Sara 
Published: September 2022

AbstractMeaningful and inclusive involvement of all people affected by research in the design, management and dissemination of that research requires skills, time, flexibility and resources. There continue to be research practices that create implicit and explicit exclusion of some members of the public who may be ‘seldom heard’ or ‘frequently ignored’. Our focus is particularly on the involvement of people living with cognitive impairment, including people with one of the many forms of dementia and people with learning disabilities. We reflect especially on issues relating to the precommencement stage of research. We suggest that despite pockets of creative good practice, research culture remains a distinct habitus that continues to privilege cognition and articulacy in numerous ways. We argue that in perpetuating this system, some researchers and the institutions that govern research are committing a form of bureaucratic violence. We call for a reimagining of the models of research governance, funding and processes to incorporate the time and flexibility that are essential for meaningful involved research, particularly at the precommencement stage. Only then will academic health and social science research that is truly collaborative, engaged, accessible and inclusive be commonplace.Public and Patient ContributionThis viewpoint article was written by a research network of academics with substantial experience in undertaking and researching patient and public involvement and codesign work with representatives of the public and patients right across the health system. Our work guided the focus of this viewpoint as we reflected on our experiences.
Barriers of and strategies for shared decision‐making implementation in the care of metastatic breast cancer: A qualitative study among patients and healthcare professionals in an Asian country
Authors: Lee Ping Yein , Cheong Ai Theng , Ghazali Sazlina Shariff , Rashid Aneesa Abdul , Ong Siu Ching , Ong Soo Ying , Alip Adlinda , Sylvia McCarthy , Chen May Feng , Taib Nur Aishah , Jaganathan Maheswari , Ng Chirk Jenn , Teo Soo‐Hwang 
Published: September 2022

AbstractBackgroundShared decision‐making has been shown to improve the quality of life in metastatic breast cancer patients in high‐literacy and high‐resource settings. However, limited studies have examined the cultural preferences of metastatic breast cancer patients with shared decision‐making implementation and the barriers encountered in an Asian setting where societal norms predominate and physician decision‐making is at the forefront. This paper aims to identify (1) barriers to practising shared decision‐making faced by healthcare professionals and patients and (2) strategies for implementing shared decision‐making in the context of metastatic breast cancer management in Malaysia.MethodsWe conducted a qualitative study involving 12 patients diagnosed with metastatic breast cancer, 16 healthcare professionals and 5 policymakers from surgical and oncology departments at public healthcare centres in Malaysia. Semi‐structured in‐depth interviews and focus group discussions were conducted. The interviews were recorded, transcribed verbatim and analysed using the thematic approach. Nvivo software was used to manage and analyse the data.ResultsFive main themes emerged from the study: healthcare provider–patient communication, workforce availability, cultural and belief systems, goals of care and paternalism versus autonomy. Other strategies proposed to overcome barriers to implementing shared decision‐making were training of healthcare professionals and empowering nurses to manage patients' psychosocial issues.ConclusionThis study found that practising shared decision‐making in the public health sector remains challenging when managing patients with metastatic breast cancer. The utilization of decision‐making tools, patient empowerment and healthcare provider training may help address the system and healthcare provider–patient barriers identified in this study.Patient or Public ContributionPatients were involved in the study design, recruitment and analysis.
Effects of wet milling on the properties of highland barley flour and the quality of highland barley bread
Authors: He Yue , Xi Huihan , Chen Zhiying , Nie Mengzi , Qin Wanyu , Wang Aixia , Liu Liya , Wang Lili , Sun Jing , Bai Yajuan , Huang Yatao , Wang Fengzhong , Tong Li‐Tao 
Published: September 2022

SummaryTo explore the effects of wet milling method on highland barley flour and highland barley bread, we investigated the characteristics of highland barley flours and the quality of highland barley breads made from whole grain highland barley flour (WGBF), dry‐milled highland barley flour (DBF) and wet‐milled highland barley flour (WBF). Compared to other highland barley flours, WBF had lower damaged starch content (1.37 g/100 g), higher pasting temperature and higher gel strength. In addition, WBF with large particles exhibited low hydration performance. These properties induced a large specific volume (2.62 mL g−1) and good crumb structure of bread with WBF. However, due to the negative effects of damaged starch and insoluble dietary fibre in WGBF and DBF, the specific volumes of bread with WGBF and DBF (1.30 and 1.70 mL g−1) were lower than the bread with WBF. The results showed that WBF with high starch granules integrity could produce preferable highland barley bread.