bluuebunny/crossref_metadata_2025_split huggingface dataset:
European-wide antimicrobial resistance monitoring in commensal Escherichia coli isolated from healthy food animals between 2004 and 2018
Authors: De Jong Anno , El Garch Farid , Hocquet Didier , Prenger-Berninghoff Ellen , Dewulf Jeroen , Migura-Garcia Lourdes , Perrin-Guyomard Agnès , Veldman Kees T , Janosi Szilard , Skarzynska Magdalena , Simjee Shabbir , Moyaert Hilde , Rose Markus ,   EASSA Study Group, Ocak Marion , Butty Pascal , Klee Rebecca , Schiffer Guido , Stevenin Clelia , Serreyn Pieter-Jan , Temmerman Robin 
Published: October 2022

Abstract

Objectives
To describe the susceptibility of Escherichia coli to medically important antibiotics, collected over four periods (2004–2006, 2008–2009, 2013–2014, 2017–2018), from food-producing animals at slaughter.

Methods
Intestinal contents from cattle, pigs and broilers were randomly sampled (5–6 countries/host; ≥4 abattoirs/country; one sample/animal/farm) for isolation of Escherichia coli; antimicrobial susceptibilities were centrally determined by CLSI agar dilution. Clinical breakpoints (CLSI) and epidemiological cut-off values (EUCAST) were applied for data interpretation.

Results
In total, 10 613 E. coli strains were recovered. In broilers, resistance percentages were the lowest (P ≤ 0.01) in the latest time period. A significant decrease in MDR over time was also observed for broilers and a tendency for a decrease for pigs. Resistance to meropenem and tigecycline was absent, and resistance to azithromycin was 0.2%–2.0%. Also, low resistance to third-generation cephalosporins (1.1%–7.4%) was detected in broilers. Resistance to colistin varied between 0.1%–4.8%. E. coli from broilers showed high resistance to ciprofloxacin (7.3%–23.3%), whereas for cattle and pigs this was 0.2%–2.5%. Low/moderate resistance to chloramphenicol (9.3%–21.3%) and gentamicin (0.9%–7.0%) was observed in pigs and broilers. The highest resistance was noted for ampicillin (32.7%–65.3%), tetracycline (41.3%–67.5%), trimethoprim (32.0%–35.7%) and trimethoprim/sulfamethoxazole (27.5%–49.7%) from pigs and broilers, with marked country differences. MDR peaked in pigs and broilers with 24 and 26 phenotypes, with 21.9%–26.2% and 18.7%–34.1% resistance, respectively.

Conclusions
In this pan-EU survey antibiotic susceptibility of commensal E. coli varied largely between antibiotics, animal species and countries. Resistance to critically important antibiotics for human medicine was absent or low, except for ciprofloxacin in broilers and ampicillin in pigs and broilers.
Frequency of drug-induced liver injury in children receiving anti-staphylococcal penicillins
Authors: Tang Kailey , Coombs Stefan , Gwee Amanda 
Published: October 2022

Abstract

Introduction
Anti-staphylococcal penicillins (ASPs) are among the most commonly prescribed antibiotics in children and are associated with a risk of drug-induced liver injury (DILI). Despite the frequent use of ASPs in children, there is no consensus on whether liver function tests (LFTs) should be routinely monitored during treatment.

Objectives
To review the literature on the frequency of ASP-related DILI in children to determine the incidence, risk factors and outcomes of hepatotoxicity.

Methods
PubMed, MEDLINE and Embase were searched in January 2022 for original studies of children who received cloxacillin, dicloxacillin, flucloxacillin, methicillin, nafcillin or oxacillin that included ≥10 children aged up to 18 years, and presented data on the incidence of DILI in children exposed to ASPs.

Results
Overall, two studies of oral flucloxacillin, two of intravenous (IV) methicillin, three of IV nafcillin and four of IV oxacillin were included. The mean onset of DILI ranged between 7.0 and 19.0 days following commencement of antibiotic treatment and all episodes resolved between 14.2 and 16.0 days after drug discontinuation, with no specific treatment required. This review found that the incidence of DILI in children was 1 in 50 000 for oral flucloxacillin and ranged from 1 in 3 to 13 for IV oxacillin, methicillin and nafcillin.

Conclusions
This review found that routine LFT monitoring is not required in children receiving low dose oral flucloxacillin in a primary care setting, although pharmacovigilance is critical. For IV preparations, the existing data support routine LFT monitoring in those receiving treatment for at least 7 days.
Impact on renal function of daily and on-demand HIV pre-exposure prophylaxis in the ANRS-PREVENIR study
Authors: Liegeon Geoffroy , Assoumou Lambert , Ghosn Jade , El Mouhebb Mayssam , Palich Romain , Palacios Christia , Slama Laurence , Surgers Laure , Genin Michèle , Beniguel Lydie , Goldwirt Lauriane , Duvivier Claudine , Rojas Castro Daniela , Costagliola Dominique , Molina Jean-Michel 
Published: October 2022

Abstract

Objectives
To assess the impact on the estimated glomerular filtration rate (eGFR) of different tenofovir disoproxil/emtricitabine dosing regimens for HIV pre-exposure prophylaxis (PrEP).

Patients and methods
We included in the study individuals with baseline eGFR &gt; 50 mL/min/1.73 m2 who initiated PrEP in the ongoing ANRS-PREVENIR PrEP cohort. We retrospectively classified PrEP users in three groups: ‘on-demand’ (reported at ≥75% of study visits), ‘daily’ (≥75% of study visits) or ‘switches’. We compared the area under curve (AUC) of the eGFR variation from baseline (ΔeGFR) between groups using analysis of covariance, and assessed factors associated with a negative AUC of ΔeGFR.

Results
From May 2017 to October 2020, 1253 PrEP-naïve participants (98% of MSM) were included in the study with a median follow-up of 22 months. 499 (40%), 494 (39%) and 260 (21%) users were in the group daily, on-demand and switches, respectively, for a median number of pills taken per week of 6, 1.7 and 4. The mean AUC of the ΔeGFR was −1.09 mL/min/1.73 m2 in the daily PrEP group, −0.69 mL/min/1.73 m2 in the switches group and +0.18 mL/min/1.73 m2 with on-demand PrEP. In a model adjusted on baseline age and eGFR, the AUC of the ΔeGFR was significantly higher with on-demand PrEP compared to daily PrEP (P = 0.037). Independent factors associated with a negative AUC of ΔeGFR were a daily PrEP regimen, a switches regimen, an age &gt; 40 years and a baseline eGFR≥90 mL/min/1.73 m².

Conclusions
On-demand PrEP dosing had a smaller impact on eGFR evolution than daily PrEP, but the difference was not clinically relevant.
Protecting reproductive health information in the post-Roe era: interoperability strategies for healthcare institutions
Authors: Khanna Raman R , Murray Sara G , Wen Timothy , Salmeen Kirsten , Illangasekare Tushani , Benfield Nerys , Adler-Milstein Julia , Savage Lucia 
Published: October 2022

Abstract
On June 24, 2022, the US Supreme Court ended constitutional protections for abortion, resulting in wide variability in access from severe restrictions in many states and fewer restrictions in others. Healthcare institutions capture information about patients’ pregnancy and abortion care and, due to interoperability, may share it in ways that expose their providers and patients to social stigma and potential legal jeopardy in states with severe restrictions. In this article, we describe sources of risk to patients and providers that arise from interoperability and specify actions that institutions can take to reduce that risk. Institutions have significant power to define their practices for how and where care is documented, how patients are identified, where data are sent or hosted, and how patients are counseled, and thus should protect patients’ privacy and ability to receive medical care that is safe and legal where it is performed.
A mobile health app may improve maternal and child health knowledge and practices among rural women with limited education in Uganda: a pilot randomized controlled trial
Authors: Musiimenta Angella , Tumuhimbise Wilson , Atukunda Esther C , Mugaba Aaron T , Asasira Justus , Katusiime Jane , Zender Raphael , Pinkwart Niels , Mugyenyi Godfrey Rwambuka , Haberer Jessica E 
Published: October 2022

AbstractObjectiveThis article describes the impact of a mobile health app (MatHealth App) on maternal and child health knowledge and practices among women with limited education.Materials and methodsPregnant women initiating antenatal care (ANC) were randomized (1:1) to the MatHealth App versus routine care. Participants were followed until 6 weeks after delivery. Questionnaires for assessing knowledge and practices were administered to participants from both arms at baseline and endline. Using logistic regression, we estimated the difference in odds of having maternal health knowledge. We reviewed clinic records to capture maternal health practices.ResultsOf the 80 enrolled participants, 69 (86%) completed the study with a median follow-up of 6 months. Women in the MatHealth arm had 8.2 (P = .19), 3.6 (P = .14), and 6.4 (P = .25), respectively higher odds of knowing (1) the recommended gestation period for starting ANC, (2) the recommended number of ANC visits, and (3) the timing and frequency of recommended human immunodeficiency virus (HIV) testing, respectively, compared to those in the routine care arm. All women in the MatHealth App arm exclusively breastfed their babies, and brought them at 6 weeks for HIV testing, compared to the routine care arm. Just over half of the women attended at least 4 prenatal visits across the 2 arms. The main reason for noncompliance to ANC appointments was a lack of transport to the clinic.Discussion and conclusionThe app increased knowledge and practices although not reaching statistical significance. Future efforts can focus on addressing social and economic issues and assessing clinical outcomes.
UHPLC–MS-MS Determination of THC, CBD and Their Metabolites in Whole Blood of Light Cannabis Smokers
Authors: Lo Faro Alfredo Fabrizio , Tini Anastasio , Gottardi Josué , Pichini Simona , Carlier Jeremy , Giorgetti Raffaele , Busardò Francesco Paolo 
Published: October 2022

Abstract
“Light cannabis” is a product legally sold in Europe with Δ9-tetrahydrocannabinol (THC) concentration &lt;0.2% and variable cannabidiol (CBD) content. In this study, we aimed to assess the time courses of THC and metabolites (11-nor-9-carboxy-THC and 11-hydroxy-THC) and CBD and metabolites (CBD-7-oic acid, 7-hydroxy-CBD, 6α-hydroxy-CBD and 6β-hydroxy-CBD) in whole blood of 10 healthy participants after smoking one or four light cannabis cigarettes (0.16% THC and 5.8% CBD). Blood samples were collected 0.5–4 h after administration. Blood analysis was performed by reversed-phase ultra-performance liquid chromatography–tandem mass spectrometry in multiple reaction monitoring mode after glucuronide hydrolysis and liquid–liquid extraction in basic and acidic conditions. The method was validated following the most recent guidelines in toxicology: the method was linear, accurate, precise and sensitive (lower limits of quantification ranged from 0.005 to 0.01 ng/mL); carryover, matrix effect, recovery, process efficiency and dilution integrity were also assessed. As previously reported, the main metabolites of THC were THC-COOH and then 11-OH-THC, and the main metabolites of CBD were 7-OH-CBD and then 7-COOH-CBD. The time of the first collection, which likely occurred after the maximal concentration of most of the analytes, and the short monitoring time, up to 4 h after smoking, limited the evaluation of the pharmacokinetic parameters.
Electrical resistivity imaging of an enhanced aquifer recharge site
Authors: Fields Jon , Tandy Tyler , Halihan Todd , Ross Randall , Beak Doug , Neill Russell , Groves Justin 
Published: October 2022

Abstract
Enhanced aquifer recharge (EAR) is defined as any engineered structure or enhanced natural feature designed to convey stormwater, surface water or wastewater directly into an aquifer (e.g. aquifer storage and recovery (ASR) wells) or into the vadose zone eventually percolating to an aquifer (e.g. spreading basins, dry well, etc.; USEPA 2021). Identifying the storage and flow capabilities of complex aquifers can improve the efficacy of many conceptual site models (CSM) for sites considered for ASR projects. In a karst setting, the EAR process may be able to take advantage of natural surficial features and the increased storage capacity of karst aquifers to improve recharge to groundwater. However, the suitability for an EAR project in a karst setting depends on the maturity of the karst and its preceding epikarst. The focus of flow within the epikarst causes enlargement of fractures and karst conduits. Thus, the storage and transmissivity within the karst vary greatly. Electrical resistivity imaging (ERI) is a well-known geophysical tool for mapping fractures and sinkholes, typical in karst settings. Locating enhanced water conveyance structures of a karst aquifer can improve the design and operation of an EAR site. This study investigated the hydraulic connection between shallow and deep groundwater using ERI to identify potential flow pathways and to improve our understanding of the storage mechanisms of the epikarst. The results presented in this paper validate the effectiveness of ERI in characterizing karst/epikarst and delineating soil, bedrock and local faults and fractures in the subsurface.
A Process-based Model with Temperature, Water, and Lab-derived Data Improves Predictions of Daily Culex pipiens/restuans Mosquito Density
Authors: Shutt D P , Goodsman D W , Martinez K , Hemez Z J L , Conrad J R , Xu C , Osthus D , Russell C , Hyman J M , Manore C A 
Published: October 2022

Abstract
While the number of human cases of mosquito-borne diseases has increased in North America in the last decade, accurate modeling of mosquito population density has remained a challenge. Longitudinal mosquito trap data over the many years needed for model calibration, and validation is relatively rare. In particular, capturing the relative changes in mosquito abundance across seasons is necessary for predicting the risk of disease spread as it varies from year to year. We developed a discrete, semi-stochastic, mechanistic process-based mosquito population model that captures life-cycle egg, larva, pupa, adult stages, and diapause for Culex pipiens (Diptera, Culicidae) and Culex restuans (Diptera, Culicidae) mosquito populations. This model combines known models for development and survival into a fully connected age-structured model that can reproduce mosquito population dynamics. Mosquito development through these stages is a function of time, temperature, daylight hours, and aquatic habitat availability. The time-dependent parameters are informed by both laboratory studies and mosquito trap data from the Greater Toronto Area. The model incorporates city-wide water-body gauge and precipitation data as a proxy for aquatic habitat. This approach accounts for the nonlinear interaction of temperature and aquatic habitat variability on the mosquito life stages. We demonstrate that the full model predicts the yearly variations in mosquito populations better than a statistical model using the same data sources. This improvement in modeling mosquito abundance can help guide interventions for reducing mosquito abundance in mitigating mosquito-borne diseases like West Nile virus.
National Forest Visitation Preferences and Avenues to Participation for Urban Hispanic Recreationists in the Portland Metropolitan Area (USA)
Authors: Cerveny Lee K , McLain Rebecca J , Banis David , Helmer Matthew 
Published: October 2022

Abstract
Health benefits of outdoor recreation have been broadly demonstrated and land managers recognize the equity implications of providing safe and inclusive outdoor spaces. Data on public lands visitation and outdoor participation show that Hispanic recreationists are less likely to engage in outdoor leisure than White persons. Early studies of outdoor preferences of Hispanic persons identified a desire for large-group settings and social activities. To update our understanding of outdoor recreation needs, preferences, and constraints, we collaborated with a Latinx organization in Portland, Oregon (USA). We collaboratively designed three focus groups that combined structured engagement, cognitive sorting, and participatory mapping to elicit desired outdoor activities and settings and identify constraints and opportunities. Results suggest that urban Hispanic recreationists seek a variety of human-powered, motorized, and contemplative outdoor activities and gravitate toward familiar settings. Predominant barriers relate to a lack of experience with outdoor activities and gear and lack of exposure to public land settings.
Study Implications: Early studies about Hispanic outdoor participation emphasized preferences for social activities in group settings. Urban Hispanic recreationists in our study sought a diversity of human-powered, motorized, and contemplative outdoor activities. Guided group outings and Spanish-language materials were identified as steps to increase participation. Barriers included a lack of awareness of prospective recreation sites, the absence of recreation partners, and unfamiliarity with outdoor gear. Agencies seeking to enhance access may gain the greatest efficiencies by enabling guided group events providing gear, instruction, and companionship. Outreach efforts in Spanish detailing information about setting and safety features would be well received.
De-Bordering Solidarity: Civil Society Actors Assisting Refused Asylum Seekers in Small Cities
Authors: Dimitriadis Iraklis , Ambrosini Maurizio 
Published: October 2022

AbstractThis article elaborates on the activities developed by various actors from the civil society in favour of non-deported refused asylum seekers (NDRAS) through the lens of ‘de-bordering solidarity’. Drawing on qualitative data collected in two small Italian cities ruled by anti-immigrant coalitions, this study explores the rationales and outcomes of migrant supporters’ actions in providing help to NDRAS, thus deepening the action of pro-immigrant civil society in small urban centres. The findings show that, while civil society’s engagement in the provision of basic needs to vulnerable people is unconditional, legal advice and practical help for access to regular status can be more selective and reflect lack of human and financial resources available, the low probability of a part of NDRAS to achieve legal status, low demand in local labour markets, and social workers’ and volunteers’ subjectivities. Despite recognizing such limits in solidarity activities, this article shows that civil society in practice challenges deportation policies through practical and daily solidarity that assumes political and cultural meanings. Based on these findings, this article suggests durable solutions for addressing the issues connected with the presence of NDRAS.
Duodenal transection following blunt abdominal trauma: a case report and literature review
Authors: Alkhulaiwi Hani , Alsarrani Faisal H , Alharbi Alanood A 
Published: October 2022

Abstract
Isolated duodenal transection—a rare complication of abdominal trauma—is a challenging dilemma and difficult to diagnose. As blunt duodenal injuries vary from mild hematoma or perforation to complete transection or complex pancreaticoduodenal disruption. A 21-year-old male medically free victim of motor vehicle collision was admitted to our hospital and evaluated in ER according to ATLS protocol. Patient was stable with positive fast scan so we proceeded for abdomen computed tomography, which showed duodenal injury with possible pancreatic transection and active arterial extravasation. Based on that patient was taken for exploratory laparotomy and primary repair. Duodenal injuries can be a result of different mechanism. Typically, it was the result of crush injury, however, it can be due to shear or bursting forces. With its anatomical location, reaching the accurate diagnosis might be delayed, which is associated with higher mortality rate. Due to different scales of severity and different presentation, the management varies based on the location and the involved surrounding structures. Although complete duodenal transection is rare with blunt injuries, high clinical suspicion is necessary to detect such injury early. Studies have shown that the outcomes are highly dictated by early diagnosis and prompt management.
Empirical Best Prediction of Small Area Means Based on a Unit-Level Gamma-Poisson Model
Authors: Berg Emily 
Published: October 2022

Abstract
Existing small area estimation procedures for count data have important limitations. For instance, an M-quantile-based method is known to be less efficient than model-based procedures if the assumptions of the model hold. Also, frequentist inference procedures for Poisson generalized linear mixed models can be computationally intensive or require approximations. Furthermore, area-level models are incapable of incorporating unit-level covariates. We overcome these limitations by developing a small area estimation procedure for a unit-level gamma-Poisson model. The conjugate form of the model permits computationally simple estimation and prediction procedures. We obtain a closed-form expression for the empirical best predictor of the mean as well as a closed-form mean square error estimator. We validate the procedure through simulations. We illustrate the proposed method using a subset of data from the Iowa Seat-Belt Use survey.
Chemical and physical processes caused by electrons impacting on H2O–CO mixed ices
Authors: Huang C-H , Cecchi-Pestellini C , Ciaravella A , Jiménez-Escobar A , Hsiao L-C , Sie N-E , Chen Y-J 
Published: October 2022

ABSTRACT
Electron-induced chemistry is relevant to many processes that occur when an ionizing source interacts with matter, as in the formation of complex molecules within frozen condensates in space. We explore in this paper the radiolysis and the desorption processes affecting iced mixtures of water and carbon monoxide subjected to electron irradiation in the sub-keV regime. The experiments have been performed with the Interstellar Energetic Process System (IEPS), an ultra-high vacuum chamber equipped with an electron gun. The irradiated ices have been monitored with infrared and mass spectroscopies. We derive the chemistry and determine cross-sections for relevant processes as functions of the energy of the impacting electrons. We quantify the electron-stimulated desorption of some significant species in terms of their desorption yields, and relate these quantities to the electron penetration depth and the desorption-relevant length. The results of this study have been compared with the outcomes of similar experiments performed using pure carbon monoxide ices.
Spectroscopy of TOI-1259B – an unpolluted white dwarf companion to an inflated warm Saturn
Authors: Fitzmaurice Evan , Martin David V , Rodríguez Martínez Romy , Vallely Patrick , Stephan Alexander P , Boley Kiersten M , Pogge Rick , El-Badry Kareem , Kunovac Vedad , Triaud Amaury H M J 
Published: October 2022

ABSTRACT
TOI-1259 consists of a transiting exoplanet orbiting a main-sequence star, with a bound outer white dwarf (WDs) companion. Less than a dozen systems with this architecture are known. We conduct follow-up spectroscopy on the WD TOI-1259B using the Large Binocular Telescope to better characterize it. We observe only strong hydrogen lines, making TOI-1259B a DA WD. We see no evidence of heavy element pollution, which would have been evidence of planetary material around the WD. Such pollution is seen in $\sim 25{-}50{{\ \rm per\ cent}}$ of WDs, but it is unknown if this rate is higher or lower in TOI-1259-like systems that contain a known planet. Our spectroscopy permits an improved WD age measurement of $4.05^{+1.00}_{-0.42}$ Gyr, which matches gyrochronology of the main-sequence star. This is the first of an expanded sample of similar binaries that will allow us to calibrate these dating methods and provide a new perspective on planets in binaries.